
                                SEQUENCE LISTING

<110> Mitokor, Inc.
	Buck Institute
	Ghosh, Soumitra S.
      Fahy, Eoin D.
      Zhang, Bing
      Gibson, Bradford W.
      Taylor, Steven W.
      Glenn, Gary M.
      Warnock, Dale E.

<120> TARGETS FOR THERAPEUTIC INTERVENTION
  IDENTIFIED IN THE MITOCHONDRIAL PROTEOME
  

<130> 660088.465PC

<140> PCT                  
<141> 2003-04-04  

<160> 3025

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 459
<212> PRT
<213> Homo sapiens

<400> 1
Met Leu Lys Leu Ile Val Pro Thr Ile Met Leu Leu Pro Leu Thr Trp
 1               5                  10                  15      
Leu Ser Lys Lys His Met Ile Trp Ile Asn Thr Thr Thr His Ser Leu
            20                  25                  30          
Ile Ile Ser Ile Ile Pro Leu Leu Phe Phe Asn Gln Ile Asn Asn Asn
        35                  40                  45              
Leu Phe Ser Cys Ser Pro Thr Phe Ser Ser Asp Pro Leu Thr Thr Pro
    50                  55                  60                  
Leu Leu Met Leu Thr Thr Trp Leu Leu Pro Leu Thr Ile Met Ala Ser
65                  70                  75                  80  
Gln Arg His Leu Ser Ser Glu Pro Leu Ser Arg Lys Lys Leu Tyr Leu
                85                  90                  95      
Ser Met Leu Ile Ser Leu Gln Ile Ser Leu Ile Met Thr Phe Thr Ala
            100                 105                 110         
Thr Glu Leu Ile Met Phe Tyr Ile Phe Phe Glu Thr Thr Leu Ile Pro
        115                 120                 125             
Thr Leu Ala Ile Ile Thr Arg Trp Gly Asn Gln Pro Glu Arg Leu Asn
    130                 135                 140                 
Ala Gly Thr Tyr Phe Leu Phe Tyr Thr Leu Val Gly Ser Leu Pro Leu
145                 150                 155                 160 
Leu Ile Ala Leu Ile Tyr Thr His Asn Thr Leu Gly Ser Leu Asn Ile
                165                 170                 175     
Leu Leu Leu Thr Leu Thr Ala Gln Glu Leu Ser Asn Ser Trp Ala Asn
            180                 185                 190         
Asn Leu Met Trp Leu Ala Tyr Thr Met Ala Phe Met Val Lys Met Pro
        195                 200                 205             
Leu Tyr Gly Leu His Leu Trp Leu Pro Lys Ala His Val Glu Ala Pro
    210                 215                 220                 
Ile Ala Gly Ser Met Leu Leu Ala Ala Val Leu Leu Lys Leu Gly Gly
225                 230                 235                 240 
Tyr Gly Met Met Arg Leu Thr Leu Ile Leu Asn Pro Leu Thr Lys His
                245                 250                 255     
Met Ala Tyr Pro Phe Leu Val Leu Ser Leu Trp Gly Met Ile Met Thr
            260                 265                 270         
Ser Ser Ile Cys Leu Arg Gln Thr Asp Leu Lys Ser Leu Ile Ala Tyr
        275                 280                 285             
Ser Ser Ile Ser His Met Ala Leu Val Val Thr Ala Ile Leu Ile Gln
    290                 295                 300                 
Thr Pro Trp Ser Phe Thr Gly Ala Val Ile Leu Met Ile Ala His Gly
305                 310                 315                 320 
Leu Thr Ser Ser Leu Leu Phe Cys Leu Ala Asn Ser Asn Tyr Glu Arg
                325                 330                 335     
Thr His Ser Arg Ile Met Ile Leu Ser Gln Gly Leu Gln Thr Leu Leu
            340                 345                 350         
Pro Leu Met Ala Phe Trp Trp Leu Leu Ala Ser Leu Ala Asn Leu Ala
        355                 360                 365             
Leu Pro Pro Thr Ile Asn Leu Leu Gly Glu Leu Ser Val Leu Val Thr
    370                 375                 380                 
Thr Phe Ser Trp Ser Asn Ile Thr Leu Leu Leu Thr Gly Leu Asn Met
385                 390                 395                 400 
Leu Val Thr Ala Leu Tyr Ser Leu Tyr Met Phe Thr Thr Thr Gln Trp
                405                 410                 415     
Gly Ser Leu Thr His His Ile Asn Asn Met Lys Pro Ser Phe Thr Arg
            420                 425                 430         
Glu Asn Thr Leu Met Phe Met His Leu Ser Pro Ile Leu Leu Leu Ser
        435                 440                 445             
Leu Asn Pro Asp Ile Ile Thr Gly Phe Ser Ser
    450                 455                 


<210> 2
<211> 609
<212> PRT
<213> Homo sapiens

<400> 2
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala
 1               5                  10                  15      
Tyr Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala
            20                  25                  30          
His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu
        35                  40                  45              
Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val
    50                  55                  60                  
Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp
65                  70                  75                  80  
Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp
                85                  90                  95      
Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala
            100                 105                 110         
Asp Cys Cys Ala Lys Gln Glu Pro Gly Arg Asn Glu Cys Phe Leu Gln
        115                 120                 125             
His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val
    130                 135                 140                 
Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys
145                 150                 155                 160 
Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro
                165                 170                 175     
Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys
            180                 185                 190         
Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu
        195                 200                 205             
Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys
    210                 215                 220                 
Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val
225                 230                 235                 240 
Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser
                245                 250                 255     
Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly
            260                 265                 270         
Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile
        275                 280                 285             
Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu
    290                 295                 300                 
Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp
305                 310                 315                 320 
Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser
                325                 330                 335     
Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly
            340                 345                 350         
Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val
        355                 360                 365             
Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys
    370                 375                 380                 
Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu
385                 390                 395                 400 
Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys
                405                 410                 415     
Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu
            420                 425                 430         
Val Arg Tyr Thr Lys Lys Val Pro Glu Val Ser Thr Pro Thr Leu Val
        435                 440                 445             
Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His
    450                 455                 460                 
Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val
465                 470                 475                 480 
Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg
                485                 490                 495     
Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe
            500                 505                 510         
Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala
        515                 520                 525             
Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu
    530                 535                 540                 
Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys
545                 550                 555                 560 
Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala
                565                 570                 575     
Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe
            580                 585                 590         
Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly
        595                 600                 605             
Leu
    


<210> 3
<211> 911
<212> PRT
<213> Homo sapiens

<400> 3
Met Glu Glu Leu Gln Asp Asp Tyr Glu Asp Met Met Glu Glu Asn Leu
 1               5                  10                  15      
Glu Gln Glu Glu Tyr Glu Asp Pro Asp Ile Pro Glu Ser Gln Met Glu
            20                  25                  30          
Glu Pro Ala Ala His Asp Thr Glu Ala Thr Ala Thr Asp Tyr His Thr
        35                  40                  45              
Thr Ser His Pro Gly Thr His Glu Val Tyr Val Glu Leu Gln Glu Leu
    50                  55                  60                  
Val Met Asp Glu Lys Asn Gln Glu Leu Arg Trp Met Glu Ala Ala Arg
65                  70                  75                  80  
Trp Val Gln Leu Glu Glu Asn Leu Gly Glu Asn Gly Ala Trp Gly Arg
                85                  90                  95      
Pro His Leu Ser His Leu Thr Phe Trp Ser Leu Leu Glu Leu Arg Arg
            100                 105                 110         
Val Phe Thr Lys Gly Thr Val Leu Leu Asp Leu Gln Glu Thr Ser Leu
        115                 120                 125             
Ala Gly Val Ala Asn Gln Leu Leu Asp Arg Phe Ile Phe Glu Asp Gln
    130                 135                 140                 
Ile Arg Pro Gln Asp Arg Glu Glu Leu Leu Arg Ala Leu Leu Leu Lys
145                 150                 155                 160 
His Ser His Ala Gly Glu Leu Glu Ala Leu Gly Gly Val Lys Pro Ala
                165                 170                 175     
Val Leu Thr Arg Ser Gly Asp Pro Ser Gln Pro Leu Leu Pro Gln His
            180                 185                 190         
Ser Ser Leu Glu Thr Gln Leu Phe Cys Glu Gln Gly Asp Gly Gly Thr
        195                 200                 205             
Glu Gly His Ser Pro Ser Gly Ile Leu Glu Lys Ile Pro Pro Asp Ser
    210                 215                 220                 
Glu Ala Thr Leu Val Leu Val Gly Arg Ala Asp Phe Leu Glu Gln Pro
225                 230                 235                 240 
Val Leu Gly Phe Val Arg Leu Gln Glu Ala Ala Glu Leu Glu Ala Val
                245                 250                 255     
Glu Leu Pro Val Pro Ile Arg Phe Leu Phe Val Leu Leu Gly Pro Glu
            260                 265                 270         
Ala Pro His Ile Asp Tyr Thr Gln Leu Gly Arg Ala Ala Ala Thr Leu
        275                 280                 285             
Met Ser Glu Arg Val Phe Arg Ile Asp Ala Tyr Met Ala Gln Ser Arg
    290                 295                 300                 
Gly Glu Leu Leu His Ser Leu Glu Gly Phe Leu Asp Cys Ser Leu Val
305                 310                 315                 320 
Leu Pro Pro Thr Asp Ala Pro Ser Glu Gln Ala Leu Leu Ser Leu Val
                325                 330                 335     
Pro Val Gln Arg Glu Leu Leu Arg Arg Arg Tyr Gln Ser Ser Pro Ala
            340                 345                 350         
Lys Pro Asp Ser Ser Phe Tyr Lys Gly Leu Asp Leu Asn Gly Gly Pro
        355                 360                 365             
Asp Asp Pro Leu Gln Gln Thr Gly Gln Leu Phe Gly Gly Leu Val Arg
    370                 375                 380                 
Asp Ile Arg Arg Arg Tyr Pro Tyr Tyr Leu Ser Asp Ile Thr Asp Ala
385                 390                 395                 400 
Phe Ser Pro Gln Val Leu Ala Ala Val Ile Phe Ile Tyr Phe Ala Ala
                405                 410                 415     
Leu Ser Pro Ala Ile Thr Phe Gly Gly Leu Leu Gly Glu Lys Thr Arg
            420                 425                 430         
Asn Gln Met Gly Val Ser Glu Leu Leu Ile Ser Thr Ala Val Gln Gly
        435                 440                 445             
Ile Leu Phe Ala Leu Leu Gly Ala Gln Pro Leu Leu Val Val Gly Phe
    450                 455                 460                 
Ser Gly Pro Leu Leu Val Phe Glu Glu Ala Phe Phe Ser Phe Cys Glu
465                 470                 475                 480 
Thr Asn Gly Leu Glu Tyr Ile Val Gly Arg Val Trp Ile Gly Phe Trp
                485                 490                 495     
Leu Ile Leu Leu Val Val Leu Val Val Ala Phe Glu Gly Ser Phe Leu
            500                 505                 510         
Val Arg Phe Ile Ser Arg Tyr Thr Gln Glu Ile Phe Ser Phe Leu Ile
        515                 520                 525             
Ser Leu Ile Phe Ile Tyr Glu Thr Phe Ser Lys Leu Ile Lys Ile Phe
    530                 535                 540                 
Gln Asp His Pro Leu Gln Lys Thr Tyr Asn Tyr Asn Val Leu Met Val
545                 550                 555                 560 
Pro Lys Pro Gln Gly Pro Leu Pro Asn Thr Ala Leu Leu Ser Leu Val
                565                 570                 575     
Leu Met Ala Gly Thr Phe Phe Phe Ala Met Met Leu Arg Lys Phe Lys
            580                 585                 590         
Asn Ser Ser Tyr Phe Pro Gly Lys Leu Arg Arg Val Ile Gly Asp Phe
        595                 600                 605             
Gly Val Pro Ile Ser Ile Leu Ile Met Val Leu Val Asp Phe Phe Ile
    610                 615                 620                 
Gln Asp Thr Tyr Thr Gln Lys Leu Ser Val Pro Asp Gly Phe Lys Val
625                 630                 635                 640 
Ser Asn Ser Ser Ala Arg Gly Trp Val Ile His Pro Leu Gly Leu Arg
                645                 650                 655     
Ser Glu Phe Pro Ile Trp Met Met Phe Ala Ser Ala Leu Pro Ala Leu
            660                 665                 670         
Leu Val Phe Ile Leu Ile Phe Leu Glu Ser Gln Ile Thr Thr Leu Ile
        675                 680                 685             
Val Ser Lys Pro Glu Arg Lys Met Val Lys Gly Ser Gly Phe His Leu
    690                 695                 700                 
Asp Leu Leu Leu Val Val Gly Met Gly Gly Val Ala Ala Leu Phe Gly
705                 710                 715                 720 
Met Pro Trp Leu Ser Ala Thr Thr Val Arg Ser Val Thr His Ala Asn
                725                 730                 735     
Ala Leu Thr Val Met Gly Lys Ala Ser Thr Pro Gly Ala Ala Ala Gln
            740                 745                 750         
Ile Gln Glu Val Lys Glu Gln Arg Ile Ser Gly Leu Leu Val Ala Val
        755                 760                 765             
Leu Val Gly Leu Ser Ile Leu Met Glu Pro Ile Leu Ser Arg Ile Pro
    770                 775                 780                 
Leu Ala Val Leu Phe Gly Ile Phe Leu Tyr Met Gly Val Thr Ser Leu
785                 790                 795                 800 
Ser Gly Ile Gln Leu Phe Asp Arg Ile Leu Leu Leu Phe Lys Pro Pro
                805                 810                 815     
Lys Tyr His Pro Asp Val Pro Tyr Val Lys Arg Val Lys Thr Trp Arg
            820                 825                 830         
Met His Leu Phe Thr Gly Ile Gln Ile Ile Cys Leu Ala Val Leu Trp
        835                 840                 845             
Val Val Lys Ser Thr Pro Ala Ser Leu Ala Leu Pro Phe Val Leu Ile
    850                 855                 860                 
Leu Thr Val Pro Leu Arg Arg Val Leu Leu Pro Leu Ile Phe Arg Asn
865                 870                 875                 880 
Val Glu Leu Gln Cys Leu Asp Ala Asp Asp Ala Lys Ala Thr Phe Asp
                885                 890                 895     
Glu Glu Glu Gly Arg Asp Glu Tyr Asp Glu Val Ala Met Pro Val
            900                 905                 910     


<210> 4
<211> 397
<212> PRT
<213> Homo sapiens

<400> 4
Ala Gly Ala Pro Gly Pro His Gly Pro Val Gly Pro Ala Gly Lys His
 1               5                  10                  15      
Gly Asn Arg Gly Glu Thr Gly Pro Ser Gly Pro Val Gly Pro Ala Gly
            20                  25                  30          
Ala Val Gly Pro Arg Gly Pro Ser Gly Pro Gln Gly Ile Arg Gly Asp
        35                  40                  45              
Lys Gly Glu Pro Gly Glu Lys Gly Pro Arg Gly Leu Pro Gly Leu Lys
    50                  55                  60                  
Gly His Asn Gly Leu Gln Gly Leu Pro Gly Ile Ala Gly His His Gly
65                  70                  75                  80  
Asp Gln Gly Ala Pro Gly Ser Val Gly Pro Ala Gly Pro Arg Gly Pro
                85                  90                  95      
Ala Gly Pro Ser Gly Pro Ala Gly Lys Asp Gly Arg Thr Gly His Pro
            100                 105                 110         
Gly Thr Val Gly Pro Ala Gly Ile Arg Gly Pro Gln Gly His Gln Gly
        115                 120                 125             
Pro Ala Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Val
    130                 135                 140                 
Ser Gly Gly Gly Tyr Asp Phe Gly Tyr Asp Gly Asp Phe Tyr Arg Ala
145                 150                 155                 160 
Asp Gln Pro Arg Ser Ala Pro Ser Leu Arg Pro Lys Asp Tyr Glu Val
                165                 170                 175     
Asp Ala Thr Leu Lys Ser Leu Asn Asn Gln Ile Glu Thr Leu Leu Thr
            180                 185                 190         
Pro Glu Gly Ser Arg Lys Asn Pro Ala Arg Thr Cys Arg Asp Leu Arg
        195                 200                 205             
Leu Ser His Pro Glu Trp Ser Ser Gly Tyr Tyr Trp Ile Asp Pro Asn
    210                 215                 220                 
Gln Gly Cys Thr Met Asp Ala Ile Lys Val Tyr Cys Asp Phe Ser Thr
225                 230                 235                 240 
Gly Glu Thr Cys Ile Arg Ala Gln Pro Glu Asn Ile Pro Ala Lys Asn
                245                 250                 255     
Trp Tyr Arg Ser Ser Lys Asp Lys Lys His Val Trp Leu Gly Glu Thr
            260                 265                 270         
Ile Asn Ala Gly Ser Gln Phe Glu Tyr Asn Val Glu Gly Val Thr Ser
        275                 280                 285             
Lys Glu Met Ala Thr Gln Leu Ala Phe Met Arg Leu Leu Ala Asn Tyr
    290                 295                 300                 
Ala Ser Gln Asn Ile Thr Tyr His Cys Lys Asn Ser Ile Ala Tyr Met
305                 310                 315                 320 
Asp Glu Glu Thr Gly Asn Leu Lys Lys Ala Val Ile Leu Gln Gly Ser
                325                 330                 335     
Asn Asp Val Glu Leu Val Ala Glu Gly Asn Ser Arg Phe Thr Tyr Thr
            340                 345                 350         
Val Leu Val Asp Gly Cys Ser Lys Lys Thr Asn Glu Trp Gly Lys Thr
        355                 360                 365             
Ile Ile Glu Tyr Lys Thr Asn Lys Pro Ser Arg Leu Pro Phe Leu Asp
    370                 375                 380                 
Ile Ala Pro Leu Asp Ile Gly Gly Ala Asp His Glu Phe
385                 390                 395         


<210> 5
<211> 280
<212> PRT
<213> Homo sapiens

<400> 5
Met Ala Leu Leu Leu Val Ser Leu Leu Ala Phe Leu Arg Leu Gly Ser
 1               5                  10                  15      
Gly Cys His His Arg Ile Cys His Cys Ser Asn Arg Val Phe Leu Cys
            20                  25                  30          
Gln Glu Ser Lys Val Thr Glu Ile Pro Ser Asp Leu Pro Arg Asn Ala
        35                  40                  45              
Ile Glu Leu Arg Phe Val Leu Thr Lys Leu Arg Val Ile Gln Lys Gly
    50                  55                  60                  
Ala Phe Ser Gly Phe Gly Asp Leu Glu Lys Ile Glu Ile Ser Gln Asn
65                  70                  75                  80  
Asp Val Leu Glu Val Ile Glu Ala Asp Val Phe Ser Asn Leu Pro Lys
                85                  90                  95      
Leu His Glu Ile Arg Ile Glu Lys Ala Asn Asn Leu Leu Tyr Ile Asn
            100                 105                 110         
Pro Glu Ala Phe Gln Asn Leu Pro Asn Leu Gln Tyr Leu Leu Ile Ser
        115                 120                 125             
Asn Thr Gly Ile Lys His Leu Pro Asp Val His Lys Ile His Ser Leu
    130                 135                 140                 
Gln Lys Val Leu Leu Asp Ile Gln Asp Asn Ile Asn Ile His Thr Ile
145                 150                 155                 160 
Glu Arg Asn Ser Phe Val Gly Leu Ser Phe Glu Ser Val Ile Leu Trp
                165                 170                 175     
Leu Asn Lys Asn Gly Ile Gln Glu Ile His Asn Cys Ala Phe Asn Gly
            180                 185                 190         
Thr Gln Leu Asp Glu Leu Asn Leu Ser Asp Asn Asn Asn Leu Glu Glu
        195                 200                 205             
Leu Pro Asn Asp Val Phe His Gly Ala Ser Gly Pro Val Ile Leu Ser
    210                 215                 220                 
Glu Leu His Pro Ile Cys Asn Lys Pro Ile Leu Arg Gln Glu Val Asp
225                 230                 235                 240 
Tyr Met Thr Gln Thr Arg Gly Gln Arg Ser Ser Leu Ala Glu Asp Asn
                245                 250                 255     
Glu Ser Ser Tyr Ser Arg Gly Phe Asp Met Thr Tyr Thr Glu Phe Asp
            260                 265                 270         
Tyr Asp Leu Cys Asn Glu Val Val
        275                 280 


<210> 6
<211> 335
<212> PRT
<213> Homo sapiens

<400> 6
Met Gly Lys Val Lys Val Gly Val Asn Gly Phe Gly Arg Ile Gly Arg
 1               5                  10                  15      
Leu Val Thr Arg Ala Ala Phe Asn Ser Gly Lys Val Asp Ile Val Ala
            20                  25                  30          
Ile Asn Asp Pro Phe Ile Asp Leu Asn Tyr Met Val Tyr Met Phe Gln
        35                  40                  45              
Tyr Asp Ser Thr His Gly Lys Phe His Gly Thr Val Lys Ala Glu Asn
    50                  55                  60                  
Gly Lys Leu Val Ile Asn Gly Asn Pro Ile Thr Ile Phe Gln Glu Arg
65                  70                  75                  80  
Asp Pro Ser Lys Ile Lys Trp Gly Asp Ala Gly Ala Glu Tyr Val Val
                85                  90                  95      
Glu Ser Thr Gly Val Phe Thr Thr Met Glu Lys Ala Gly Ala His Leu
            100                 105                 110         
Gln Gly Gly Ala Lys Arg Val Ile Ile Ser Ala Pro Ser Ala Asp Ala
        115                 120                 125             
Pro Met Phe Val Met Gly Val Asn His Glu Lys Tyr Asp Asn Ser Leu
    130                 135                 140                 
Lys Ile Ile Ser Asn Ala Ser Cys Thr Thr Asn Cys Leu Ala Pro Leu
145                 150                 155                 160 
Ala Lys Val Ile His Asp Asn Phe Gly Ile Val Glu Gly Leu Met Thr
                165                 170                 175     
Thr Val His Ala Ile Thr Ala Thr Gln Lys Thr Val Asp Gly Pro Ser
            180                 185                 190         
Gly Lys Leu Trp Arg Asp Gly Arg Gly Ala Leu Gln Asn Ile Ile Pro
        195                 200                 205             
Ala Ser Thr Gly Ala Ala Lys Ala Val Gly Lys Val Ile Pro Glu Leu
    210                 215                 220                 
Asp Gly Lys Leu Thr Gly Met Ala Phe Arg Val Pro Thr Ala Asn Val
225                 230                 235                 240 
Ser Val Val Asp Leu Thr Cys Arg Leu Glu Lys Pro Ala Lys Tyr Asp
                245                 250                 255     
Asp Ile Lys Lys Val Val Lys Gln Ala Ser Glu Gly Pro Leu Lys Gly
            260                 265                 270         
Ile Leu Gly Tyr Thr Glu His Gln Val Val Ser Ser Asp Phe Asn Ser
        275                 280                 285             
Asp Thr His Ser Ser Thr Phe Asp Ala Gly Ala Gly Ile Ala Leu Asn
    290                 295                 300                 
Asp His Phe Val Lys Leu Ile Ser Trp Tyr Asp Asn Glu Phe Gly Tyr
305                 310                 315                 320 
Ser Asn Arg Val Val Asp Leu Met Ala His Met Ala Ser Lys Glu
                325                 330                 335 


<210> 7
<211> 216
<212> PRT
<213> Homo sapiens

<400> 7
Ser Asp His Thr Asp Asn Gln Arg Ile Leu Glu Phe Phe Gly Leu Lys
 1               5                  10                  15      
Lys Glu Glu Cys Pro Ala Val Arg Leu Ile Thr Leu Glu Glu Glu Met
            20                  25                  30          
Thr Lys Tyr Lys Pro Glu Ser Glu Glu Leu Thr Ala Glu Arg Ile Thr
        35                  40                  45              
Glu Phe Cys His Arg Phe Leu Glu Gly Lys Ile Lys Pro His Leu Met
    50                  55                  60                  
Ser Gln Glu Leu Pro Glu Asp Trp Asp Lys Gln Pro Val Lys Val Leu
65                  70                  75                  80  
Val Gly Lys Asn Phe Glu Asp Val Ala Phe Asp Glu Lys Lys Asn Val
                85                  90                  95      
Phe Val Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Gln Leu Ala
            100                 105                 110         
Pro Ile Trp Asp Lys Leu Gly Glu Thr Tyr Lys Asp His Glu Asn Ile
        115                 120                 125             
Val Ile Ala Lys Met Asp Ser Thr Ala Asn Glu Val Glu Ala Val Lys
    130                 135                 140                 
Val His Ser Phe Pro Thr Leu Lys Phe Phe Pro Ala Ser Ala Asp Arg
145                 150                 155                 160 
Thr Val Ile Asp Tyr Asn Gly Gln Arg Thr Leu Asp Gly Phe Lys Lys
                165                 170                 175     
Phe Leu Glu Ser Gly Gly Gln Asp Gly Ala Gly Asp Asp Asp Asp Leu
            180                 185                 190         
Glu Asp Leu Glu Glu Ala Glu Glu Pro Asp Met Glu Glu Asp Asp Asp
        195                 200                 205             
Gln Lys Ala Val Lys Asp Glu Leu
    210                 215     


<210> 8
<211> 631
<212> PRT
<213> Homo sapiens

<400> 8
Asn Pro Gly Lys Gln Leu Phe Glu Lys Met Val Ser Gly Met Tyr Leu
 1               5                  10                  15      
Gly Glu Leu Val Arg Leu Ile Leu Val Lys Met Ala Lys Glu Gly Leu
            20                  25                  30          
Leu Phe Glu Gly Arg Ile Thr Pro Glu Leu Leu Thr Arg Gly Lys Phe
        35                  40                  45              
Asn Thr Ser Asp Val Ser Ala Ile Glu Lys Asn Lys Glu Gly Leu His
    50                  55                  60                  
Asn Ala Lys Glu Ile Leu Thr Arg Leu Gly Val Glu Pro Ser Asp Asp
65                  70                  75                  80  
Asp Cys Val Ser Val Gln His Val Cys Thr Ile Val Ser Phe Arg Ser
                85                  90                  95      
Ala Asn Leu Val Ala Ala Thr Leu Gly Ala Ile Leu Asn Arg Leu Arg
            100                 105                 110         
Asp Asn Lys Gly Thr Pro Arg Leu Arg Thr Thr Val Gly Val Asp Gly
        115                 120                 125             
Ser Leu Tyr Lys Thr His Pro Gln Tyr Ser Arg Arg Phe His Lys Thr
    130                 135                 140                 
Leu Arg Arg Leu Val Pro Asp Ser Asp Val Arg Phe Leu Leu Ser Glu
145                 150                 155                 160 
Ser Gly Ser Gly Lys Gly Ala Ala Met Val Thr Ala Val Ala Tyr Arg
                165                 170                 175     
Leu Ala Glu Gln His Arg Gln Ile Glu Glu Thr Leu Ala His Phe His
            180                 185                 190         
Leu Thr Lys Asp Met Leu Leu Glu Val Lys Lys Arg Met Arg Ala Glu
        195                 200                 205             
Met Glu Leu Gly Leu Arg Lys Gln Thr His Asn Asn Ala Val Val Lys
    210                 215                 220                 
Met Leu Pro Ser Phe Val Arg Arg Thr Pro Asp Gly Thr Glu Asn Gly
225                 230                 235                 240 
Asp Phe Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val Leu Leu
                245                 250                 255     
Val Lys Ile Arg Ser Gly Lys Lys Arg Thr Val Glu Met His Asn Lys
            260                 265                 270         
Ile Tyr Ala Ile Pro Ile Glu Ile Met Gln Gly Thr Gly Glu Glu Leu
        275                 280                 285             
Phe Asp His Ile Val Ser Cys Ile Ser Asp Phe Leu Asp Tyr Met Gly
    290                 295                 300                 
Ile Lys Gly Pro Arg Met Pro Leu Gly Phe Thr Phe Ser Phe Pro Cys
305                 310                 315                 320 
Gln Gln Thr Ser Leu Asp Ala Gly Ile Leu Ile Thr Trp Thr Lys Gly
                325                 330                 335     
Phe Lys Ala Thr Asp Cys Val Gly His Asp Val Val Thr Leu Leu Arg
            340                 345                 350         
Asp Ala Ile Lys Arg Arg Glu Glu Phe Asp Leu Asp Val Val Ala Val
        355                 360                 365             
Val Asn Asp Thr Val Gly Thr Met Met Thr Cys Ala Tyr Glu Glu Pro
    370                 375                 380                 
Thr Cys Glu Val Gly Leu Ile Val Gly Thr Gly Ser Asn Ala Cys Tyr
385                 390                 395                 400 
Met Glu Glu Met Lys Asn Val Glu Met Val Glu Gly Asp Gln Gly Gln
                405                 410                 415     
Met Cys Ile Asn Met Glu Trp Gly Ala Phe Gly Asp Asn Gly Cys Leu
            420                 425                 430         
Asp Asp Ile Arg Thr His Tyr Asp Arg Leu Val Asn Glu Tyr Ser Leu
        435                 440                 445             
Asn Ala Gly Lys Gln Arg Tyr Glu Lys Met Ile Ser Gly Met Tyr Leu
    450                 455                 460                 
Gly Glu Ile Val Arg Asn Ile Leu Ile Asp Phe Thr Lys Lys Gly Phe
465                 470                 475                 480 
Leu Phe Arg Gly Gln Ile Ser Glu Thr Met Lys Thr Arg Gly Ile Phe
                485                 490                 495     
Glu Thr Lys Phe Leu Ser Gln Ile Glu Ser Asp Arg Leu Ala Leu Leu
            500                 505                 510         
Gln Val Arg Ala Ile Leu Gln Gln Leu Gly Leu Asn Ser Thr Cys Asp
        515                 520                 525             
Asp Ser Ile Leu Val Lys Thr Val Cys Gly Val Val Ser Arg Arg Ala
    530                 535                 540                 
Ala Gln Leu Cys Gly Ala Gly Met Ala Ala Val Val Asp Lys Ile Arg
545                 550                 555                 560 
Glu Asn Arg Gly Leu Asp Arg Leu Asn Val Thr Val Gly Val Asp Gly
                565                 570                 575     
Thr Leu Tyr Lys Leu His Pro His Phe Ser Arg Ile Met His Gln Thr
            580                 585                 590         
Val Lys Glu Leu Ser Pro Lys Cys Asn Val Ser Phe Leu Leu Ser Glu
        595                 600                 605             
Asp Gly Ser Gly Lys Gly Ala Ala Leu Ile Thr Ala Val Gly Val Arg
    610                 615                 620                 
Leu Arg Thr Glu Ala Ser Ser
625                 630     


<210> 9
<211> 745
<212> PRT
<213> Homo sapiens

<400> 9
Met Gly Val Pro Phe Phe Ser Ser Leu Arg Cys Met Val Asp Leu Gly
 1               5                  10                  15      
Pro Cys Trp Ala Gly Gly Leu Thr Ala Glu Met Lys Leu Leu Leu Ala
            20                  25                  30          
Leu Ala Gly Val Leu Ala Ile Leu Ala Thr Pro Gln Pro Ser Glu Gly
        35                  40                  45              
Ala Ala Pro Ala Val Leu Gly Glu Val Asp Thr Ser Leu Val Leu Ser
    50                  55                  60                  
Ser Met Glu Glu Ala Lys Gln Leu Val Asp Lys Ala Tyr Lys Glu Arg
65                  70                  75                  80  
Arg Glu Ser Ile Lys Gln Arg Leu Arg Ser Gly Ser Ala Ser Pro Met
                85                  90                  95      
Glu Leu Leu Ser Tyr Phe Lys Gln Pro Val Ala Ala Thr Arg Thr Ala
            100                 105                 110         
Val Arg Ala Ala Asp Tyr Leu His Val Ala Leu Asp Leu Leu Glu Arg
        115                 120                 125             
Lys Leu Arg Ser Leu Trp Arg Arg Pro Phe Asn Val Thr Asp Val Leu
    130                 135                 140                 
Thr Pro Ala Gln Leu Asn Val Leu Ser Lys Ser Ser Gly Cys Ala Tyr
145                 150                 155                 160 
Gln Asp Val Gly Val Thr Cys Pro Glu Gln Asp Lys Tyr Arg Thr Ile
                165                 170                 175     
Thr Gly Met Cys Asn Asn Arg Arg Ser Pro Thr Leu Gly Ala Ser Asn
            180                 185                 190         
Arg Ala Phe Val Arg Trp Leu Pro Ala Glu Tyr Glu Asp Gly Phe Ser
        195                 200                 205             
Leu Pro Tyr Gly Trp Thr Pro Gly Val Lys Arg Asn Gly Phe Pro Val
    210                 215                 220                 
Ala Leu Ala Arg Ala Val Ser Asn Glu Ile Val Arg Phe Pro Thr Asp
225                 230                 235                 240 
Gln Leu Thr Pro Asp Gln Glu Arg Ser Leu Met Phe Met Gln Trp Gly
                245                 250                 255     
Gln Leu Leu Asp His Asp Leu Asp Phe Thr Pro Glu Pro Ala Ala Arg
            260                 265                 270         
Ala Ser Phe Val Thr Gly Val Asn Cys Glu Thr Ser Cys Val Gln Gln
        275                 280                 285             
Pro Pro Cys Phe Pro Leu Lys Ile Pro Pro Asn Asp Pro Arg Ile Lys
    290                 295                 300                 
Asn Gln Ala Asp Cys Ile Pro Phe Phe Arg Ser Cys Pro Ala Cys Pro
305                 310                 315                 320 
Gly Ser Asn Ile Thr Ile Arg Asn Gln Ile Asn Ala Leu Thr Ser Phe
                325                 330                 335     
Val Asp Ala Ser Met Val Tyr Gly Ser Glu Glu Pro Leu Ala Arg Asn
            340                 345                 350         
Leu Arg Asn Met Ser Asn Gln Leu Gly Leu Leu Ala Val Asn Gln Arg
        355                 360                 365             
Phe Gln Asp Asn Gly Arg Ala Leu Leu Pro Phe Asp Asn Leu His Asp
    370                 375                 380                 
Asp Pro Cys Leu Leu Thr Asn Arg Ser Ala Arg Ile Pro Cys Phe Leu
385                 390                 395                 400 
Ala Gly Asp Thr Arg Ser Ser Glu Met Pro Glu Leu Thr Ser Met His
                405                 410                 415     
Thr Leu Leu Leu Arg Glu His Asn Arg Leu Ala Thr Glu Leu Lys Ser
            420                 425                 430         
Leu Asn Pro Arg Trp Asp Gly Glu Arg Leu Tyr Gln Glu Ala Arg Lys
        435                 440                 445             
Ile Val Gly Ala Met Val Gln Ile Ile Thr Tyr Arg Asp Tyr Leu Pro
    450                 455                 460                 
Leu Val Leu Gly Pro Thr Ala Met Arg Lys Tyr Leu Pro Thr Tyr Arg
465                 470                 475                 480 
Ser Tyr Asn Asp Ser Val Asp Pro Arg Ile Ala Asn Val Phe Thr Asn
                485                 490                 495     
Ala Phe Arg Tyr Gly His Thr Leu Ile Gln Pro Phe Met Phe Arg Leu
            500                 505                 510         
Asp Asn Arg Tyr Gln Pro Met Glu Pro Asn Pro Arg Val Pro Leu Ser
        515                 520                 525             
Arg Val Phe Phe Ala Ser Trp Arg Val Val Leu Glu Gly Gly Ile Asp
    530                 535                 540                 
Pro Ile Leu Arg Gly Leu Met Ala Thr Pro Ala Lys Leu Asn Arg Gln
545                 550                 555                 560 
Asn Gln Ile Ala Val Asp Glu Ile Arg Glu Arg Leu Phe Glu Gln Val
                565                 570                 575     
Met Arg Ile Gly Leu Asp Leu Pro Ala Leu Asn Met Gln Arg Ser Arg
            580                 585                 590         
Asp His Gly Leu Pro Gly Tyr Asn Ala Trp Arg Arg Phe Cys Gly Leu
        595                 600                 605             
Pro Gln Pro Glu Thr Val Gly Gln Leu Gly Thr Val Leu Arg Asn Leu
    610                 615                 620                 
Lys Leu Ala Arg Lys Leu Met Glu Gln Tyr Gly Thr Pro Asn Asn Ile
625                 630                 635                 640 
Asp Ile Trp Met Gly Gly Val Ser Glu Pro Leu Lys Arg Lys Gly Arg
                645                 650                 655     
Val Gly Pro Leu Leu Ala Cys Ile Ile Gly Thr Gln Phe Arg Lys Leu
            660                 665                 670         
Arg Asp Gly Asp Arg Phe Trp Trp Glu Asn Glu Gly Val Phe Ser Met
        675                 680                 685             
Gln Gln Arg Gln Ala Leu Ala Gln Ile Ser Leu Pro Arg Ile Ile Cys
    690                 695                 700                 
Asp Asn Thr Gly Ile Thr Thr Val Ser Lys Asn Asn Ile Phe Met Ser
705                 710                 715                 720 
Asn Ser Tyr Pro Arg Asp Phe Val Asn Cys Ser Thr Leu Pro Ala Leu
                725                 730                 735     
Asn Leu Ala Ser Trp Arg Glu Ala Ser
            740                 745 


<210> 10
<211> 478
<212> PRT
<213> Homo sapiens

<400> 10
Met Ala Pro Leu Arg Pro Leu Leu Ile Leu Ala Leu Leu Ala Trp Val
 1               5                  10                  15      
Ala Leu Ala Asp Gln Glu Ser Cys Lys Gly Arg Cys Thr Glu Gly Phe
            20                  25                  30          
Asn Val Asp Lys Lys Cys Gln Cys Asp Glu Leu Cys Ser Tyr Tyr Gln
        35                  40                  45              
Ser Cys Cys Thr Asp Tyr Thr Ala Glu Cys Lys Pro Gln Val Thr Arg
    50                  55                  60                  
Gly Asp Val Phe Thr Met Pro Glu Asp Glu Tyr Thr Val Tyr Asp Asp
65                  70                  75                  80  
Gly Glu Glu Lys Asn Asn Ala Thr Val His Glu Gln Val Gly Gly Pro
                85                  90                  95      
Ser Leu Thr Ser Asp Leu Gln Ala Gln Ser Lys Gly Asn Pro Glu Gln
            100                 105                 110         
Thr Pro Val Leu Lys Pro Glu Glu Glu Ala Pro Ala Pro Glu Val Gly
        115                 120                 125             
Ala Ser Lys Pro Glu Gly Ile Asp Ser Arg Pro Glu Thr Leu His Pro
    130                 135                 140                 
Gly Arg Pro Gln Pro Pro Ala Glu Glu Glu Leu Cys Ser Gly Lys Pro
145                 150                 155                 160 
Phe Asp Ala Phe Thr Asp Leu Lys Asn Gly Ser Leu Phe Ala Phe Arg
                165                 170                 175     
Gly Gln Tyr Cys Tyr Glu Leu Asp Glu Lys Ala Val Arg Pro Gly Tyr
            180                 185                 190         
Pro Lys Leu Ile Arg Asp Val Trp Gly Ile Glu Gly Pro Ile Asp Ala
        195                 200                 205             
Ala Phe Thr Arg Ile Asn Cys Gln Gly Lys Thr Tyr Leu Phe Lys Gly
    210                 215                 220                 
Asn Gln Tyr Trp Arg Phe Glu Asp Gly Val Leu Asp Pro Asp Tyr Pro
225                 230                 235                 240 
Arg Asn Ile Ser Asp Gly Phe Asp Gly Ile Pro Asp Asn Val Asp Ala
                245                 250                 255     
Ala Leu Ala Leu Pro Ala His Ser Tyr Ser Gly Arg Glu Arg Val Tyr
            260                 265                 270         
Phe Phe Lys Gly Lys Gln Tyr Trp Glu Tyr Gln Phe Gln His Gln Pro
        275                 280                 285             
Ser Gln Glu Glu Cys Glu Gly Ser Ser Leu Ser Ala Val Phe Glu His
    290                 295                 300                 
Phe Ala Met Met Gln Arg Asp Ser Trp Glu Asp Ile Phe Glu Leu Leu
305                 310                 315                 320 
Phe Trp Gly Arg Thr Ser Ala Gly Thr Arg Gln Pro Gln Phe Ile Ser
                325                 330                 335     
Arg Asp Trp His Gly Val Pro Gly Gln Val Asp Ala Ala Met Ala Gly
            340                 345                 350         
Arg Ile Tyr Ile Ser Gly Met Ala Pro Arg Pro Ser Leu Ala Lys Lys
        355                 360                 365             
Gln Arg Phe Arg His Arg Asn Arg Lys Gly Tyr Arg Ser Gln Arg Gly
    370                 375                 380                 
His Ser Arg Gly Arg Asn Gln Asn Ser Arg Arg Pro Ser Arg Ala Met
385                 390                 395                 400 
Trp Leu Ser Leu Phe Ser Ser Glu Glu Ser Asn Leu Gly Ala Asn Asn
                405                 410                 415     
Tyr Asp Asp Tyr Arg Met Asp Trp Leu Val Pro Ala Thr Cys Glu Pro
            420                 425                 430         
Ile Gln Ser Val Phe Phe Phe Ser Gly Asp Lys Tyr Tyr Arg Val Asn
        435                 440                 445             
Leu Arg Thr Arg Arg Val Asp Thr Val Asp Pro Pro Tyr Pro Arg Ser
    450                 455                 460                 
Ile Ala Gln Tyr Trp Leu Gly Cys Pro Ala Pro Gly His Leu
465                 470                 475             


<210> 11
<211> 724
<212> PRT
<213> Homo sapiens

<400> 11
Met Pro Glu Glu Val His His Gly Glu Glu Glu Val Glu Thr Phe Ala
 1               5                  10                  15      
Phe Gln Ala Glu Ile Ala Gln Leu Met Ser Leu Ile Ile Asn Thr Phe
            20                  25                  30          
Tyr Ser Asn Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ala Ser
        35                  40                  45              
Asp Ala Leu Asp Lys Ile Arg Tyr Glu Ser Leu Thr Asp Pro Ser Lys
    50                  55                  60                  
Leu Asp Ser Gly Lys Glu Leu Lys Ile Asp Ile Ile Pro Asn Pro Gln
65                  70                  75                  80  
Glu Arg Thr Leu Thr Leu Val Asp Thr Gly Ile Gly Met Thr Lys Ala
                85                  90                  95      
Asp Leu Ile Asn Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Lys Ala
            100                 105                 110         
Phe Met Glu Ala Leu Gln Ala Gly Ala Asp Ile Ser Met Ile Gly Gln
        115                 120                 125             
Phe Gly Val Gly Phe Tyr Ser Ala Tyr Leu Val Ala Glu Lys Val Val
    130                 135                 140                 
Val Ile Arg Lys His Asn Asp Asp Glu Gln Tyr Ala Trp Glu Ser Ser
145                 150                 155                 160 
Ala Gly Gly Ser Phe Thr Val Arg Ala Asp His Gly Glu Pro Ile Gly
                165                 170                 175     
Met Gly Thr Lys Val Ile Leu His Leu Lys Glu Asp Gln Thr Glu Tyr
            180                 185                 190         
Leu Glu Glu Arg Arg Val Lys Glu Val Val Lys Lys His Ser Gln Phe
        195                 200                 205             
Ile Gly Tyr Pro Ile Thr Leu Tyr Leu Glu Lys Glu Arg Glu Lys Glu
    210                 215                 220                 
Ile Ser Asp Asp Glu Ala Glu Glu Glu Lys Gly Glu Lys Glu Glu Glu
225                 230                 235                 240 
Asp Lys Asp Asp Glu Glu Lys Pro Lys Ile Glu Asp Val Gly Ser Asp
                245                 250                 255     
Glu Glu Asp Asp Ser Gly Lys Asp Lys Lys Lys Lys Thr Lys Lys Ile
            260                 265                 270         
Lys Glu Lys Tyr Ile Asp Gln Glu Glu Leu Asn Lys Thr Lys Pro Ile
        275                 280                 285             
Trp Thr Arg Asn Pro Asp Asp Ile Thr Gln Glu Glu Tyr Gly Glu Phe
    290                 295                 300                 
Tyr Lys Ser Leu Thr Asn Asp Trp Glu Asp His Leu Ala Val Lys His
305                 310                 315                 320 
Phe Ser Val Glu Gly Gln Leu Glu Phe Arg Ala Leu Leu Phe Ile Pro
                325                 330                 335     
Arg Arg Ala Pro Phe Asp Leu Phe Glu Asn Lys Lys Lys Lys Asn Asn
            340                 345                 350         
Ile Lys Leu Tyr Val Arg Arg Val Phe Ile Met Asp Ser Cys Asp Glu
        355                 360                 365             
Leu Ile Pro Glu Tyr Leu Asn Phe Ile Arg Gly Val Val Asp Ser Glu
    370                 375                 380                 
Asp Leu Pro Leu Asn Ile Ser Arg Glu Met Leu Gln Gln Ser Lys Ile
385                 390                 395                 400 
Leu Lys Val Ile Arg Lys Asn Ile Val Lys Lys Cys Leu Glu Leu Phe
                405                 410                 415     
Ser Glu Leu Ala Glu Asp Lys Glu Asn Tyr Lys Lys Phe Tyr Glu Ala
            420                 425                 430         
Phe Ser Lys Asn Leu Lys Leu Gly Ile His Glu Asp Ser Thr Asn Arg
        435                 440                 445             
Arg Arg Leu Ser Glu Leu Leu Arg Tyr His Thr Ser Gln Ser Gly Asp
    450                 455                 460                 
Glu Met Thr Ser Leu Ser Glu Tyr Val Ser Arg Met Lys Glu Thr Gln
465                 470                 475                 480 
Lys Ser Ile Tyr Tyr Ile Thr Gly Glu Ser Lys Glu Gln Val Ala Asn
                485                 490                 495     
Ser Ala Phe Val Glu Arg Val Arg Lys Arg Gly Phe Glu Val Val Tyr
            500                 505                 510         
Met Thr Glu Pro Ile Asp Glu Tyr Cys Val Gln Gln Leu Lys Glu Phe
        515                 520                 525             
Asp Gly Lys Ser Leu Val Ser Val Thr Lys Glu Gly Leu Glu Leu Pro
    530                 535                 540                 
Glu Asp Glu Glu Glu Lys Lys Lys Met Glu Glu Ser Lys Ala Lys Phe
545                 550                 555                 560 
Glu Asn Leu Cys Lys Leu Met Lys Glu Ile Leu Asp Lys Lys Val Glu
                565                 570                 575     
Lys Val Thr Ile Ser Asn Arg Leu Val Ser Ser Pro Cys Cys Ile Val
            580                 585                 590         
Thr Ser Thr Tyr Gly Trp Thr Ala Asn Met Glu Arg Ile Met Lys Ala
        595                 600                 605             
Gln Ala Leu Arg Asp Asn Ser Thr Met Gly Tyr Met Met Ala Lys Lys
    610                 615                 620                 
His Leu Glu Ile Asn Pro Asp His Pro Ile Val Glu Thr Leu Arg Gln
625                 630                 635                 640 
Lys Ala Glu Ala Asp Lys Asn Asp Lys Ala Val Lys Asp Leu Val Val
                645                 650                 655     
Leu Leu Phe Glu Thr Ala Leu Leu Ser Ser Gly Phe Ser Leu Glu Asp
            660                 665                 670         
Pro Gln Thr His Ser Asn Arg Ile Tyr Arg Met Ile Lys Leu Gly Leu
        675                 680                 685             
Gly Ile Asp Glu Asp Glu Val Ala Ala Glu Glu Pro Asn Ala Ala Val
    690                 695                 700                 
Pro Asp Glu Ile Pro Pro Leu Glu Gly Asp Glu Asp Ala Ser Arg Met
705                 710                 715                 720 
Glu Glu Val Asp
                


<210> 12
<211> 262
<212> PRT
<213> Homo sapiens

<400> 12
Leu Gln Val Gln His Ala Ser Lys Gln Ile Ala Ala Asp Lys Gln Tyr
 1               5                  10                  15      
Lys Gly Ile Val Asp Cys Ile Val Arg Ile Pro Lys Glu Gln Gly Val
            20                  25                  30          
Leu Ser Phe Trp Arg Gly Asn Leu Ala Asn Val Ile Arg Tyr Phe Pro
        35                  40                  45              
Thr Gln Ala Leu Asn Phe Ala Phe Lys Asp Lys Tyr Lys Gln Ile Phe
    50                  55                  60                  
Leu Gly Gly Val Asp Arg His Ala Phe Trp Arg Tyr Phe Ala Gly Asn
65                  70                  75                  80  
Leu Ala Ser Gly Gly Ala Ala Gly Ala Thr Ser Leu Cys Phe Val Tyr
                85                  90                  95      
Pro Leu Asp Phe Ala Arg Thr Arg Leu Ala Ala Asp Val Gly Lys Ser
            100                 105                 110         
Gly Thr Glu Arg Glu Phe Arg Gly Leu Gly Asp Cys Leu Val Lys Ile
        115                 120                 125             
Thr Lys Ser Asp Gly Ile Arg Gly Leu Tyr Gln Gly Phe Ser Val Ser
    130                 135                 140                 
Val Gln Gly Ile Ile Ile Tyr Arg Ala Ala Tyr Phe Gly Val Tyr Asp
145                 150                 155                 160 
Thr Ala Lys Gly Met Leu Pro Asp Pro Lys Asn Thr His Ile Val Val
                165                 170                 175     
Ser Trp Met Ile Ala Gln Thr Val Thr Ala Val Ala Gly Val Val Ser
            180                 185                 190         
Tyr Pro Phe Asp Thr Val Arg Arg Arg Met Met Met Gln Ser Gly Arg
        195                 200                 205             
Lys Gly Ala Asp Ile Met Tyr Thr Gly Thr Val Asp Cys Trp Arg Lys
    210                 215                 220                 
Ile Phe Arg Asp Glu Gly Gly Lys Ala Phe Phe Lys Gly Ala Trp Ser
225                 230                 235                 240 
Asn Val Leu Arg Gly Met Gly Gly Ala Phe Val Leu Val Leu Tyr Asp
                245                 250                 255     
Glu Leu Lys Lys Val Ile
            260         


<210> 13
<211> 653
<212> PRT
<213> Homo sapiens

<400> 13
Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Ala Ala
 1               5                  10                  15      
Arg Ala Glu Glu Glu Asp Lys Lys Glu Asp Val Gly Thr Val Val Gly
            20                  25                  30          
Ile Asp Leu Gly Thr Thr Tyr Ser Cys Val Gly Val Phe Lys Asn Gly
        35                  40                  45              
Arg Val Glu Ile Ile Ala Asn Asp Gln Gly Asn Arg Ile Thr Pro Ser
    50                  55                  60                  
Tyr Val Ala Phe Thr Pro Glu Gly Glu Arg Leu Ile Gly Asp Ala Ala
65                  70                  75                  80  
Lys Asn Gln Leu Thr Ser Asn Pro Glu Asn Thr Val Phe Asp Ala Lys
                85                  90                  95      
Arg Leu Ile Gly Arg Thr Trp Asn Asp Pro Ser Val Gln Gln Asp Ile
            100                 105                 110         
Lys Phe Leu Pro Phe Lys Val Val Glu Lys Lys Thr Lys Pro Tyr Ile
        115                 120                 125             
Gln Val Asp Ile Gly Gly Gly Gln Thr Lys Thr Phe Ala Pro Glu Glu
    130                 135                 140                 
Ile Ser Ala Met Val Leu Thr Lys Met Lys Glu Thr Ala Glu Ala Tyr
145                 150                 155                 160 
Leu Gly Lys Lys Val Thr His Ala Val Val Thr Val Pro Ala Tyr Phe
                165                 170                 175     
Asn Asp Ala Gln Arg Gln Ala Thr Lys Asp Ala Gly Thr Ile Ala Gly
            180                 185                 190         
Leu Asn Val Met Arg Ile Ile Asn Glu Pro Thr Ala Ala Ala Ile Ala
        195                 200                 205             
Tyr Gly Leu Asp Lys Arg Glu Gly Glu Lys Asn Ile Leu Val Phe Asp
    210                 215                 220                 
Leu Gly Gly Gly Thr Phe Asp Val Ser Leu Leu Thr Ile Asp Asn Gly
225                 230                 235                 240 
Val Phe Glu Val Val Ala Thr Asn Gly Asp Thr His Leu Gly Gly Glu
                245                 250                 255     
Asp Phe Asp Gln Arg Val Met Glu His Phe Ile Lys Leu Tyr Lys Lys
            260                 265                 270         
Lys Thr Gly Lys Asp Val Arg Lys Asp Asn Arg Ala Val Gln Lys Leu
        275                 280                 285             
Arg Arg Glu Val Glu Lys Ala Lys Ala Leu Ser Ser Gln His Gln Ala
    290                 295                 300                 
Arg Ile Glu Ile Glu Ser Phe Tyr Glu Gly Glu Asp Phe Ser Glu Thr
305                 310                 315                 320 
Leu Thr Arg Ala Lys Phe Glu Glu Leu Asn Met Asp Leu Phe Arg Ser
                325                 330                 335     
Thr Met Lys Pro Val Gln Lys Val Leu Glu Asp Ser Asp Leu Lys Lys
            340                 345                 350         
Ser Asp Ile Asp Glu Ile Val Leu Val Gly Gly Ser Thr Arg Ile Pro
        355                 360                 365             
Lys Ile Gln Gln Leu Val Lys Glu Phe Phe Asn Gly Lys Glu Pro Ser
    370                 375                 380                 
Arg Gly Ile Asn Pro Asp Glu Ala Val Ala Tyr Gly Ala Ala Val Gln
385                 390                 395                 400 
Ala Gly Val Leu Ser Gly Asp Gln Asp Thr Gly Asp Leu Val Leu Leu
                405                 410                 415     
His Val Cys Pro Leu Thr Leu Gly Ile Glu Thr Val Gly Gly Val Met
            420                 425                 430         
Thr Lys Leu Ile Pro Ser Asn Thr Val Val Pro Thr Lys Asn Ser Gln
        435                 440                 445             
Ile Phe Ser Thr Ala Ser Asp Asn Gln Pro Thr Val Thr Ile Lys Val
    450                 455                 460                 
Tyr Glu Gly Glu Arg Pro Leu Thr Lys Asp Asn His Leu Leu Gly Thr
465                 470                 475                 480 
Phe Asp Leu Thr Gly Ile Pro Pro Ala Pro Arg Gly Val Pro Gln Ile
                485                 490                 495     
Glu Val Thr Phe Glu Ile Asp Val Asn Gly Ile Leu Arg Val Thr Ala
            500                 505                 510         
Glu Asp Lys Gly Thr Gly Asn Lys Asn Lys Ile Thr Ile Thr Asn Asp
        515                 520                 525             
Gln Asn Arg Leu Thr Pro Glu Glu Ile Glu Arg Met Val Asn Asp Ala
    530                 535                 540                 
Glu Lys Phe Ala Glu Glu Asp Lys Lys Leu Lys Glu Arg Ile Asp Thr
545                 550                 555                 560 
Arg Asn Glu Leu Glu Ser Tyr Ala Tyr Ser Leu Lys Asn Gln Ile Gly
                565                 570                 575     
Asp Lys Glu Lys Leu Gly Gly Lys Leu Ser Ser Glu Asp Lys Glu Thr
            580                 585                 590         
Met Glu Lys Ala Val Glu Glu Lys Ile Glu Trp Leu Glu Ser His Gln
        595                 600                 605             
Asp Ala Asp Ile Glu Asp Phe Lys Ala Lys Lys Lys Glu Leu Glu Glu
    610                 615                 620                 
Ile Val Gln Pro Ile Ile Ser Lys Leu Tyr Gly Ser Ala Gly Pro Pro
625                 630                 635                 640 
Pro Thr Gly Glu Glu Asp Thr Ala Glu Lys Asp Glu Leu
                645                 650             


<210> 14
<211> 228
<212> PRT
<213> Homo sapiens

<400> 14
Met Ala Trp Lys Ser Gly Gly Ala Ser His Ser Glu Leu Ile His Asn
 1               5                  10                  15      
Leu Arg Lys Asn Gly Ile Ile Lys Thr Asp Lys Val Phe Glu Val Met
            20                  25                  30          
Leu Ala Thr Asp Arg Ser His Tyr Ala Lys Cys Asn Pro Tyr Met Asp
        35                  40                  45              
Ser Pro Gln Ser Ile Gly Phe Gln Ala Thr Ile Ser Ala Pro His Met
    50                  55                  60                  
His Ala Tyr Ala Leu Glu Leu Leu Phe Asp Gln Leu His Glu Gly Ala
65                  70                  75                  80  
Lys Ala Leu Asp Val Gly Ser Gly Ser Gly Ile Leu Thr Ala Cys Phe
                85                  90                  95      
Ala Arg Met Val Gly Cys Thr Gly Lys Val Ile Gly Ile Asp His Ile
            100                 105                 110         
Lys Glu Leu Val Asp Asp Ser Val Asn Asn Val Arg Lys Asp Asp Pro
        115                 120                 125             
Thr Leu Leu Ser Ser Gly Arg Val Gln Leu Val Val Gly Asp Gly Arg
    130                 135                 140                 
Met Gly Tyr Ala Glu Glu Ala Pro Tyr Asp Ala Ile His Val Gly Ala
145                 150                 155                 160 
Ala Ala Pro Val Val Pro Gln Ala Leu Ile Asp Gln Leu Lys Pro Gly
                165                 170                 175     
Gly Arg Leu Ile Leu Pro Val Gly Pro Ala Gly Gly Asn Gln Met Leu
            180                 185                 190         
Glu Gln Tyr Asp Lys Leu Gln Asp Gly Ser Ile Lys Met Lys Pro Leu
        195                 200                 205             
Met Gly Val Ile Tyr Val Pro Leu Thr Asp Lys Glu Lys Gln Trp Ser
    210                 215                 220                 
Arg Asp Glu Leu
225             


<210> 15
<211> 262
<212> PRT
<213> Homo sapiens

<400> 15
Trp Arg Thr Cys Leu Gln Ala Ser Arg Gly Ala Gln Thr Ala Ala Ala
 1               5                  10                  15      
Thr Ala Pro Arg Ile Lys Lys Phe Ala Ile Tyr Arg Trp Asp Pro Asp
            20                  25                  30          
Lys Ala Gly Asp Lys Pro His Met Gln Thr Tyr Lys Val Asp Leu Asn
        35                  40                  45              
Lys Cys Gly Pro Met Val Leu Asp Ala Leu Ile Lys Ile Lys Asn Glu
    50                  55                  60                  
Val Asp Ser Thr Leu Thr Phe Arg Arg Ser Cys Arg Glu Gly Ile Cys
65                  70                  75                  80  
Gly Ser Cys Ala Met Asn Ile Asn Gly Gly Asn Thr Leu Ala Cys Thr
                85                  90                  95      
Arg Arg Ile Asp Thr Asn Leu Asn Lys Val Ser Lys Ile Tyr Pro Leu
            100                 105                 110         
Pro His Met Tyr Val Ile Lys Asp Leu Val Pro Asp Leu Ser Asn Phe
        115                 120                 125             
Tyr Ala Gln Tyr Lys Ser Ile Glu Pro Tyr Leu Lys Lys Lys Asp Glu
    130                 135                 140                 
Ser Gln Glu Gly Lys Gln Gln Tyr Leu Gln Ser Ile Glu Glu Arg Glu
145                 150                 155                 160 
Lys Leu Asp Gly Leu Tyr Glu Cys Ile Leu Cys Ala Cys Cys Ser Thr
                165                 170                 175     
Ser Cys Pro Ser Tyr Trp Trp Asn Gly Asp Lys Tyr Leu Gly Pro Ala
            180                 185                 190         
Val Leu Met Gln Ala Tyr Arg Trp Met Ile Asp Ser Arg Asp Asp Phe
        195                 200                 205             
Thr Glu Glu Arg Leu Ala Lys Leu Gln Asp Pro Phe Ser Leu Tyr Arg
    210                 215                 220                 
Cys His Thr Ile Met Asn Cys Thr Arg Thr Cys Pro Lys Gly Leu Asn
225                 230                 235                 240 
Pro Gly Lys Ala Ile Ala Glu Ile Lys Lys Met Met Ala Thr Tyr Lys
                245                 250                 255     
Glu Lys Lys Ala Ser Val
            260         


<210> 16
<211> 34
<212> PRT
<213> Homo sapiens

<400> 16
Ala Asp Asn Asn Phe Thr Gln Glu Thr Ala Met Thr Met Ile Thr Ile
 1               5                  10                  15      
Ser Ala Gln Lys Asn Pro Thr Val Phe Tyr Leu Cys Ala Ser Ser Arg
            20                  25                  30          
Asp Ile
        


<210> 17
<211> 843
<212> PRT
<213> Homo sapiens

<400> 17
Phe Asp Val Gly Ser Glu Lys Thr Arg Ile Gly Leu Ala Gln Tyr Ser
 1               5                  10                  15      
Gly Asp Pro Arg Ile Glu Trp His Leu Asn Ala Phe Ser Thr Lys Asp
            20                  25                  30          
Glu Val Ile Glu Ala Val Arg Asn Leu Pro Tyr Lys Gly Gly Asn Thr
        35                  40                  45              
Leu Thr Gly Leu Ala Leu Asn Tyr Ile Phe Glu Asn Ser Phe Lys Pro
    50                  55                  60                  
Glu Ala Gly Ser Arg Thr Gly Val Ser Lys Ile Gly Ile Leu Ile Thr
65                  70                  75                  80  
Asp Gly Lys Ser Gln Asp Asp Ile Ile Pro Pro Ser Arg Asn Leu Arg
                85                  90                  95      
Glu Ser Gly Val Glu Leu Phe Ala Ile Gly Val Lys Asn Ala Asp Val
            100                 105                 110         
Asn Glu Leu Gln Glu Ile Ala Ser Glu Pro Asp Ser Thr His Val Tyr
        115                 120                 125             
Asn Val Ala Glu Phe Asp Leu Met His Thr Val Val Glu Ser Leu Thr
    130                 135                 140                 
Arg Thr Leu Cys Ser Arg Val Glu Glu Gln Asp Arg Glu Ile Lys Ala
145                 150                 155                 160 
Ser Ala His Ala Ile Thr Gly Pro Pro Thr Glu Leu Ile Thr Ser Glu
                165                 170                 175     
Val Thr Ala Arg Ser Phe Met Val Asn Trp Thr His Ala Pro Gly Asn
            180                 185                 190         
Val Glu Lys Tyr Arg Val Val Tyr Tyr Pro Thr Arg Gly Gly Lys Pro
        195                 200                 205             
Asp Glu Val Val Val Asp Gly Thr Val Ser Ser Thr Val Leu Lys Asn
    210                 215                 220                 
Leu Met Ser Leu Thr Glu Tyr Gln Ile Ala Val Phe Ala Ile Tyr Ala
225                 230                 235                 240 
His Thr Ala Ser Glu Gly Leu Arg Gly Thr Glu Thr Thr Leu Ala Leu
                245                 250                 255     
Pro Met Ala Ser Asp Leu Leu Leu Tyr Asp Val Thr Glu Asn Ser Met
            260                 265                 270         
Arg Val Lys Trp Asp Ala Val Pro Gly Ala Ser Gly Tyr Leu Ile Leu
        275                 280                 285             
Tyr Ala Pro Leu Thr Glu Gly Leu Ala Gly Asp Glu Lys Glu Met Lys
    290                 295                 300                 
Ile Gly Glu Thr His Thr Asp Ile Glu Leu Ser Gly Leu Leu Pro Asn
305                 310                 315                 320 
Thr Glu Tyr Thr Val Thr Val Tyr Ala Met Phe Gly Glu Glu Ala Ser
                325                 330                 335     
Asp Pro Val Thr Gly Gln Glu Thr Thr Leu Ala Leu Ser Pro Pro Arg
            340                 345                 350         
Asn Leu Arg Ile Ser Asn Val Gly Ser Asn Ser Ala Arg Leu Thr Trp
        355                 360                 365             
Asp Pro Thr Ser Arg Gln Ile Asn Gly Tyr Arg Ile Val Tyr Asn Asn
    370                 375                 380                 
Ala Asp Gly Thr Glu Ile Asn Glu Val Glu Val Asp Pro Ile Thr Thr
385                 390                 395                 400 
Phe Pro Leu Lys Gly Leu Thr Pro Leu Thr Glu Tyr Thr Ile Ala Ile
                405                 410                 415     
Phe Ser Ile Tyr Asp Glu Gly Gln Ser Glu Pro Leu Ile Gly Val Phe
            420                 425                 430         
Thr Thr Glu Glu Val Pro Ala Gln Gln Tyr Leu Glu Ile Asp Glu Val
        435                 440                 445             
Thr Thr Asp Ser Phe Arg Val Thr Trp His Pro Leu Ser Ala Asp Glu
    450                 455                 460                 
Gly Leu His Lys Leu Met Trp Ile Pro Val Tyr Gly Gly Lys Thr Glu
465                 470                 475                 480 
Glu Val Val Leu Lys Glu Glu Gln Asp Ser His Val Ile Glu Gly Leu
                485                 490                 495     
Glu Pro Gly Thr Glu Tyr Glu Val Ser Leu Leu Ala Val Leu Asp Asp
            500                 505                 510         
Gly Ser Glu Ser Glu Val Val Thr Ala Val Gly Thr Thr Leu Asp Ser
        515                 520                 525             
Phe Trp Thr Glu Pro Ala Thr Thr Ile Val Pro Thr Thr Ser Val Thr
    530                 535                 540                 
Ser Val Phe Gln Thr Gly Ile Arg Asn Leu Val Val Gly Asp Glu Thr
545                 550                 555                 560 
Thr Ser Ser Leu Arg Val Lys Trp Asp Ile Ser Asp Ser Asp Val Gln
                565                 570                 575     
Gln Phe Arg Val Thr Tyr Met Thr Ala Gln Gly Asp Pro Glu Glu Glu
            580                 585                 590         
Val Ile Gly Thr Val Met Val Pro Gly Ser Gln Asn Asn Leu Leu Leu
        595                 600                 605             
Lys Pro Leu Leu Pro Asp Thr Glu Tyr Lys Val Thr Val Thr Pro Ile
    610                 615                 620                 
Tyr Thr Asp Gly Glu Gly Val Ser Val Ser Ala Pro Gly Lys Thr Leu
625                 630                 635                 640 
Pro Ser Ser Gly Pro Gln Asn Leu Arg Val Ser Glu Glu Trp Tyr Asn
                645                 650                 655     
Arg Leu Arg Ile Thr Trp Asp Pro Pro Ser Ser Pro Val Lys Gly Tyr
            660                 665                 670         
Arg Ile Val Tyr Lys Pro Val Ser Val Pro Gly Pro Thr Leu Glu Thr
        675                 680                 685             
Phe Val Gly Ala Asp Ile Asn Thr Ile Leu Ile Thr Asn Leu Leu Ser
    690                 695                 700                 
Gly Met Asp Tyr Asn Val Lys Ile Phe Ala Ser Gln Ala Ser Gly Phe
705                 710                 715                 720 
Ser Asp Ala Leu Thr Gly Met Val Lys Thr Leu Phe Leu Gly Val Thr
                725                 730                 735     
Asn Leu Gln Ala Lys His Val Glu Met Thr Ser Leu Cys Ala His Trp
            740                 745                 750         
Gln Val His Arg His Ala Thr Ala Tyr Arg Val Val Ile Glu Ser Leu
        755                 760                 765             
Gln Asp Arg Gln Lys Gln Glu Ser Thr Val Gly Gly Gly Thr Thr Arg
    770                 775                 780                 
His Cys Phe Tyr Gly Leu Gln Pro Asp Ser Glu Tyr Lys Ile Ser Val
785                 790                 795                 800 
Tyr Thr Lys Leu Gln Glu Ile Glu Gly Pro Ser Val Ser Ile Met Glu
                805                 810                 815     
Lys Thr Gln Ser Leu Pro Thr Arg Pro Pro Thr Phe Pro Pro Thr Ile
            820                 825                 830         
Pro Pro Ala Lys Glu Gly Lys Arg Ile Ile Glu
        835                 840             


<210> 18
<211> 292
<212> PRT
<213> Homo sapiens

<400> 18
Met Ser Gly Gly Gly Val Ile Arg Gly Pro Ala Gly Asn Asn Asp Cys
 1               5                  10                  15      
Arg Ile Tyr Val Gly Asn Leu Pro Pro Asp Ile Arg Thr Lys Asp Ile
            20                  25                  30          
Glu Asp Val Phe Tyr Lys Tyr Gly Ala Ile Arg Asp Ile Asp Leu Lys
        35                  40                  45              
Asn Arg Arg Gly Gly Pro Pro Phe Ala Phe Val Glu Phe Glu Asp Pro
    50                  55                  60                  
Arg Asp Ala Glu Asp Ala Val Tyr Gly Arg Asp Gly Tyr Asp Tyr Asp
65                  70                  75                  80  
Gly Tyr Arg Leu Arg Val Glu Phe Pro Arg Ser Gly Arg Gly Thr Gly
                85                  90                  95      
Arg Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Pro Arg Gly Arg Tyr
            100                 105                 110         
Gly Pro Pro Ser Arg Arg Ser Glu Asn Arg Val Val Val Ser Gly Leu
        115                 120                 125             
Pro Pro Ser Gly Ser Trp Gln Asp Leu Lys Asp His Met Arg Glu Ala
    130                 135                 140                 
Gly Asp Val Cys Tyr Ala Asp Val Tyr Arg Asp Gly Thr Gly Val Val
145                 150                 155                 160 
Glu Phe Val Arg Lys Glu Asp Met Thr Tyr Ala Val Arg Lys Leu Asp
                165                 170                 175     
Asn Thr Lys Phe Arg Ser His Glu Phe Cys Leu Ser Asn Arg Glu Lys
            180                 185                 190         
Leu Pro Thr Ser Gly Leu Lys Leu Met Gly Pro Glu Val Gln Val Met
        195                 200                 205             
Glu Asp Leu Asp Leu Glu Ala Val Val Val Ala Glu Ala Val Ala Glu
    210                 215                 220                 
Ala Thr Ala Gly Val Ala Val Thr Pro Gln Gly Glu Ala Glu Asp His
225                 230                 235                 240 
His Ala Ile Leu Pro Val Ile Ala Asp Leu Ala Leu Val His Lys Met
                245                 250                 255     
Ile Gly Asp Thr Phe Cys Arg Thr His Val Val Tyr Ser Phe Pro Leu
            260                 265                 270         
Phe Ser Thr Ile Phe Ser Phe Phe Asn Ser Asn Cys Phe Val Gln Asn
        275                 280                 285             
Gly Leu Lys Cys
    290         


<210> 19
<211> 1138
<212> PRT
<213> Homo sapiens

<400> 19
Met Pro Glu Pro Thr Lys Lys Glu Glu Asn Glu Val Pro Ala Pro Ala
 1               5                  10                  15      
Pro Pro Pro Glu Glu Pro Ser Lys Glu Lys Glu Ala Gly Thr Thr Pro
            20                  25                  30          
Ala Lys Asp Trp Thr Leu Val Glu Thr Pro Pro Gly Glu Glu Gln Ala
        35                  40                  45              
Lys Gln Asn Ala Asn Ser Gln Leu Ser Ile Leu Phe Ile Glu Lys Pro
    50                  55                  60                  
Gln Gly Gly Thr Val Lys Val Gly Glu Asp Ile Thr Phe Ile Ala Lys
65                  70                  75                  80  
Val Lys Ala Glu Asp Leu Ser Glu Lys Pro Thr Ile Asn Gly Ser Arg
                85                  90                  95      
Lys Trp Met Asp Leu Ala Ser Lys Ala Gly Lys His Leu Gln Leu Lys
            100                 105                 110         
Glu Thr Phe Glu Arg His Ser Arg Val Tyr Thr Phe Glu Met Gln Ile
        115                 120                 125             
Ile Lys Ala Lys Asp Asn Phe Ala Gly Asn Tyr Arg Cys Glu Val Thr
    130                 135                 140                 
Tyr Lys Asp Lys Phe Asp Ser Cys Ser Phe Asp Leu Glu Val His Glu
145                 150                 155                 160 
Ser Thr Gly Thr Thr Pro Asn Ile Asp Ile Arg Ser Ala Phe Lys Arg
                165                 170                 175     
Ser Gly Glu Gly Gln Glu Asp Ala Gly Glu Leu Asp Phe Ser Gly Leu
            180                 185                 190         
Leu Lys Arg Arg Glu Val Lys Gln Gln Glu Glu Glu Pro Gln Val Asp
        195                 200                 205             
Val Trp Glu Leu Leu Lys Asn Thr Lys Pro Ser Glu Tyr Glu Lys Ile
    210                 215                 220                 
Ala Phe Gln Tyr Glu Ser Pro Thr Cys Ser Gly Met Leu Lys Arg Leu
225                 230                 235                 240 
Lys Arg Ser Ile Arg Glu Glu Lys Lys Ser Ala Ala Phe Ala Lys Ile
                245                 250                 255     
Leu Asp Pro Val Tyr Gln Val Asp Lys Gly Gly Arg Val Arg Phe Val
            260                 265                 270         
Val Glu Leu Ala Asp Pro Lys Leu Glu Val Lys Trp Asn Lys Asn Gly
        275                 280                 285             
Gln Glu Leu Arg Pro Ser Thr Lys Tyr Ile Phe Glu Asp Thr Arg Cys
    290                 295                 300                 
Gln Ser Ile Leu Asn Ile Asp Asn Cys Gln Met Thr Asp Asp Ser Glu
305                 310                 315                 320 
Tyr Tyr Val Thr Ala Gly Asp Glu Lys Cys Ser Thr Glu Leu Leu Val
                325                 330                 335     
Arg Glu Pro Pro Ile Met Val Thr Lys Gln Leu Glu Asp Thr Thr Asp
            340                 345                 350         
Tyr Cys Gly Glu Arg Val Glu Leu Glu Cys Glu Val Ser Glu Asp Asp
        355                 360                 365             
Ala Gln Val Lys Trp Phe Lys Asn Gly Glu Glu Ile Ile Leu Val Gln
    370                 375                 380                 
Thr Arg Tyr Arg Ile Arg Val Glu Gly Lys Lys His Ile Leu Ile Ile
385                 390                 395                 400 
Glu Gly Ala Thr Lys Ala Asp Ala Ala Asp Tyr Ser Val Met Thr Thr
                405                 410                 415     
Gly Gly Gln Ser Ser Ala Lys Leu Ser Val Asp Leu Lys Pro Leu Lys
            420                 425                 430         
Ile Leu Thr Pro Leu Thr Asp Gln Thr Val Asn Leu Gly Lys Glu Ile
        435                 440                 445             
Cys Leu Lys Cys Glu Ile Ser Glu Asn Ile Pro Gly Lys Trp Thr Lys
    450                 455                 460                 
Asn Gly Leu Pro Val Gln Glu Ser Asp Arg Leu Lys Val Val His Lys
465                 470                 475                 480 
Gly Arg Ile His Lys Leu Val Ile Asp His Ala Leu Thr Glu Asp Glu
                485                 490                 495     
Gly Asp Tyr Val Phe Ala Pro Asp Ala Tyr Asn Val Thr Leu Pro Ala
            500                 505                 510         
Lys Val His Val Ile Asp Pro Pro Lys Ile Ile Leu Asp Gly Leu Asp
        515                 520                 525             
Ala Asp Asn Thr Val Thr Val Ile Ala Gly Asn Lys Leu Arg Leu Glu
    530                 535                 540                 
Ile Pro Ile Ser Gly Glu Pro Pro Pro Lys Ala Met Trp Ser Arg Gly
545                 550                 555                 560 
Asp Lys Ala Ile Met Glu Gly Ser Gly Arg Ile Arg Thr Glu Ser Tyr
                565                 570                 575     
Pro Asp Ser Ser Thr Leu Val Ile Asp Ile Ala Glu Arg Asp Asp Ser
            580                 585                 590         
Gly Val Tyr His Ile Asn Leu Lys Asn Glu Ala Gly Glu Ala His Ala
        595                 600                 605             
Ser Ile Lys Val Lys Val Val Asp Phe Pro Asp Pro Pro Val Ala Pro
    610                 615                 620                 
Thr Val Thr Glu Val Gly Asp Asp Trp Cys Ile Met Asn Trp Glu Pro
625                 630                 635                 640 
Pro Ala Tyr Asp Gly Gly Ser Pro Ile Leu Gly Tyr Phe Ile Glu Arg
                645                 650                 655     
Lys Lys Lys Gln Ser Ser Arg Trp Met Arg Leu Asn Phe Asp Leu Cys
            660                 665                 670         
Lys Glu Thr Thr Phe Glu Pro Lys Lys Met Ile Glu Gly Val Ala Tyr
        675                 680                 685             
Glu Val Arg Ile Phe Ala Val Asn Ala Ile Gly Ile Ser Lys Pro Ser
    690                 695                 700                 
Met Pro Ser Arg Pro Phe Val Pro Leu Ala Val Thr Ser Pro Pro Thr
705                 710                 715                 720 
Leu Leu Thr Val Asp Ser Val Thr Asp Thr Thr Val Thr Met Arg Trp
                725                 730                 735     
Arg Pro Pro Asp His Ile Gly Ala Ala Gly Leu Asp Gly Tyr Val Leu
            740                 745                 750         
Glu Tyr Cys Phe Glu Gly Ser Thr Ser Ala Lys Gln Ser Asp Glu Asn
        755                 760                 765             
Gly Glu Ala Ala Tyr Asp Leu Pro Ala Glu Asp Trp Ile Val Ala Asn
    770                 775                 780                 
Lys Asp Leu Ile Asp Lys Thr Lys Phe Thr Ile Thr Gly Leu Pro Thr
785                 790                 795                 800 
Asp Ala Lys Ile Phe Val Arg Val Lys Ala Val Asn Ala Ala Gly Ala
                805                 810                 815     
Ser Glu Pro Lys Tyr Tyr Ser Gln Pro Ile Leu Val Lys Glu Ile Ile
            820                 825                 830         
Glu Pro Pro Lys Ile His Ser Pro Lys His Leu Lys Gln Thr Tyr Ile
        835                 840                 845             
Arg Arg Val Gly Asp Arg Val Ile Leu Val Ile Pro Phe Gln Gly Lys
    850                 855                 860                 
Pro Arg Pro Glu Leu Thr Trp Lys Lys Asp Gly Ala Glu Ile Asp Lys
865                 870                 875                 880 
Asn Gln Ile Asn Ile Arg Asn Ser Glu Thr Asp Thr Ile Ile Phe Ile
                885                 890                 895     
Arg Lys Ala Glu Arg Ser His Ser Gly Lys Tyr Asp Leu Gln Val Lys
            900                 905                 910         
Val Asp Lys Phe Val Glu Thr Ala Ser Ile Asp Ile Arg Ile Ile Asp
        915                 920                 925             
Arg Pro Gly Pro Pro Gln Ile Val Lys Ile Glu Asp Val Trp Gly Arg
    930                 935                 940                 
Asn Val Ala Leu Thr Trp Thr Pro Pro Lys Asp Asp Gly Asn Ala Ala
945                 950                 955                 960 
Ile Thr Gly Tyr Thr Ile Gln Lys Ala Asp Lys Lys Ser Met Glu Trp
                965                 970                 975     
Leu Arg Val Ile Glu His Ile Ile Glu Pro Val Pro His Thr Glu Leu
            980                 985                 990         
Val Ile Gly Asn Glu Tyr Tyr Phe Arg Val Phe Ser Glu Asn Met Cys
        995                 1000                1005            
Gly Leu Ser Glu Asp Ala Thr Met Thr Lys Glu Ser Ala Val Ile Ala
    1010                1015                1020                
Arg Asp Gly Lys Ile Tyr Lys Asn Pro Val Tyr Glu Asp Phe Asp Phe
1025                1030                1035                1040
Ser Glu Ala Pro Met Phe Thr Gln Pro Leu Val Asn Arg Leu Cys His
                1045                1050                1055    
Ser Gly Tyr Met Ala Thr Leu Asn Cys Ser Val Arg Gly Asn Pro Lys
            1060                1065                1070        
Pro Lys Ile Thr Trp Met Lys Asn Lys Val Ala Ile Val Asp Asp Pro
        1075                1080                1085            
Arg Tyr Arg Met Phe Ser Asn Leu Gly Val Cys Thr Leu Glu Ile Gly
    1090                1095                1100                
Lys Pro Ser Pro Tyr Asp Gly Gly Thr Tyr Cys Cys Lys Ala Val Asn
1105                1110                1115                1120
Asp Leu Gly Thr Val Glu Ile Glu Cys Lys Leu Glu Val Lys Val Ile
                1125                1130                1135    
Ala Gln
        


<210> 20
<211> 135
<212> PRT
<213> Homo sapiens

<400> 20
Met Gly Ala His Leu Val Arg Arg Tyr Leu Gly Asp Ala Ser Val Glu
 1               5                  10                  15      
Pro Asp Pro Leu Gln Met Pro Thr Phe Pro Pro Asp Tyr Gly Phe Pro
            20                  25                  30          
Glu Arg Lys Glu Arg Glu Met Val Ala Thr Gln Gln Glu Met Met Asp
        35                  40                  45              
Ala Ser Glu Ala Gln Leu Arg Asp Tyr Cys Ala His His Leu Ile Arg
    50                  55                  60                  
Leu Leu Lys Cys Lys Arg Asp Ser Phe Pro Ser Cys Trp Pro Ala Ser
65                  70                  75                  80  
Arg Lys Arg His Asp Ser Gly Leu Leu Arg Thr Ala Ser Tyr Val Met
                85                  90                  95      
Arg Met Lys Glu Phe Glu Arg Asp Glu Gly Cys Ser Ser Gly Arg Ser
            100                 105                 110         
Gly Gly Arg Arg Arg Arg Gln Ile Cys Lys Gly Gln Gly Pro Gly Glu
        115                 120                 125             
Val Asp Pro Lys Val Ala Leu
    130                 135 


<210> 21
<211> 137
<212> PRT
<213> Homo sapiens

<400> 21
Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Ala Ile Val Ser
 1               5                  10                  15      
Ile Ser Ala Ser Ser Thr Thr Gly Val Ala Met His Thr Ser Thr Ser
            20                  25                  30          
Ser Ser Val Thr Lys Ser Tyr Ile Ser Ser Gln Thr Asn Asp Thr His
        35                  40                  45              
Lys Arg Asp Thr Tyr Ala Ala Thr Pro Arg Ala His Glu Val Ser Glu
    50                  55                  60                  
Ile Ser Val Arg Thr Val Tyr Pro Pro Glu Glu Glu Thr Glu Ile Thr
65                  70                  75                  80  
Leu Ile Ile Phe Gly Val Met Ala Gly Val Ile Gly Thr Ile Leu Leu
                85                  90                  95      
Ile Ser Tyr Gly Ile Arg Arg Leu Ile Lys Lys Ser Pro Ser Asp Val
            100                 105                 110         
Lys Pro Leu Pro Ser Pro Asp Thr Asp Val Pro Leu Ser Ser Val Glu
        115                 120                 125             
Ile Glu Asn Pro Glu Thr Ser Asp Gln
    130                 135         


<210> 22
<211> 212
<212> PRT
<213> Homo sapiens

<400> 22
Met Ala Tyr Ala Tyr Leu Phe Lys Tyr Ile Ile Ile Gly Asp Thr Gly
 1               5                  10                  15      
Val Gly Lys Ser Cys Leu Leu Leu Gln Phe Thr Asp Lys Arg Phe Gln
            20                  25                  30          
Pro Val His Asp Leu Thr Ile Gly Val Glu Phe Gly Ala Arg Met Ile
        35                  40                  45              
Thr Ile Asp Gly Lys Gln Ile Lys Leu Gln Ile Trp Asp Thr Ala Gly
    50                  55                  60                  
Gln Glu Ser Phe Arg Ser Ile Thr Arg Ser Tyr Tyr Arg Gly Ala Ala
65                  70                  75                  80  
Gly Ala Leu Leu Val Tyr Asp Ile Thr Arg Arg Asp Thr Phe Asn His
                85                  90                  95      
Leu Thr Thr Trp Leu Glu Asp Ala Arg Gln His Ser Asn Ser Asn Met
            100                 105                 110         
Val Ile Met Leu Ile Gly Asn Lys Ser Asp Leu Glu Ser Arg Arg Glu
        115                 120                 125             
Val Lys Lys Glu Glu Gly Glu Ala Phe Ala Arg Glu His Gly Leu Met
    130                 135                 140                 
Phe Met Glu Thr Ser Ala Lys Thr Ala Ser Asn Val Glu Glu Ala Phe
145                 150                 155                 160 
Ile Asn Thr Ala Lys Glu Ile Tyr Glu Lys Ile Gln Glu Gly Val Phe
                165                 170                 175     
Asp Ile Asn Asn Glu Ala Asn Gly Ile Lys Ile Gly Pro Gln His Ala
            180                 185                 190         
Ala Thr Asn Ala Thr His Ala Gly Asn Gln Gly Gly Gln Gln Ala Gly
        195                 200                 205             
Gly Gly Cys Cys
    210         


<210> 23
<211> 477
<212> PRT
<213> Homo sapiens

<400> 23
Met Gly Ala Leu Ala Arg Ala Leu Pro Ser Ile Leu Leu Ala Leu Leu
 1               5                  10                  15      
Leu Thr Ser Thr Pro Glu Ala Leu Gly Ala Asn Pro Gly Leu Val Ala
            20                  25                  30          
Arg Ile Thr Asp Lys Gly Leu Gln Tyr Ala Ala Gln Glu Gly Leu Leu
        35                  40                  45              
Ala Leu Gln Ser Glu Leu Leu Arg Ile Thr Leu Pro Asp Phe Thr Gly
    50                  55                  60                  
Asp Leu Arg Ile Pro His Val Gly Arg Gly Arg Tyr Glu Phe His Ser
65                  70                  75                  80  
Leu Asn Ile His Ser Cys Glu Leu Leu His Ser Ala Leu Arg Pro Val
                85                  90                  95      
Pro Gly Gln Gly Leu Ser Leu Ser Ile Ser Asp Ser Ser Ile Arg Val
            100                 105                 110         
Gln Gly Arg Trp Lys Val Arg Lys Ser Phe Phe Lys Leu Gln Gly Ser
        115                 120                 125             
Phe Asp Val Ser Val Lys Gly Ile Ser Ile Ser Val Asn Leu Leu Leu
    130                 135                 140                 
Gly Ser Glu Ser Ser Gly Arg Pro Thr Gly Tyr Cys Leu Ser Cys Ser
145                 150                 155                 160 
Ser Asp Ile Ala Asp Val Glu Val Asp Met Ser Gly Asp Ser Gly Trp
                165                 170                 175     
Leu Leu Asn Leu Phe His Asn Gln Ile Glu Ser Lys Phe Gln Lys Val
            180                 185                 190         
Leu Glu Ser Arg Ile Cys Glu Met Ile Gln Lys Ser Val Ser Ser Asp
        195                 200                 205             
Leu Gln Pro Tyr Leu Gln Thr Leu Pro Val Thr Thr Glu Ile Asp Ser
    210                 215                 220                 
Phe Ala Asp Ile Asp Tyr Ser Leu Val Glu Ala Pro Arg Ala Thr Ala
225                 230                 235                 240 
Gln Met Leu Glu Val Met Phe Lys Gly Glu Ile Phe His Arg Asn His
                245                 250                 255     
Arg Ser Pro Val Thr Leu Leu Ala Ala Ala Glu Glu His Asn Lys Met
            260                 265                 270         
Val Tyr Phe Ala Ile Ser Asp Tyr Val Phe Asn Thr Ala Ser Leu Val
        275                 280                 285             
Tyr His Glu Glu Gly Tyr Leu Asn Phe Ser Ile Thr Asp Asp Met Ile
    290                 295                 300                 
Pro Pro Asp Ser Asn Ile Arg Leu Thr Thr Lys Ser Phe Arg Pro Phe
305                 310                 315                 320 
Val Pro Arg Leu Ala Arg Leu Tyr Pro Asn Met Asn Leu Glu Leu Gln
                325                 330                 335     
Gly Ser Val Pro Ser Ala Pro Leu Leu Asn Phe Ser Pro Gly Asn Leu
            340                 345                 350         
Ser Val Asp Pro Tyr Met Glu Ile Asp Ala Phe Val Leu Leu Pro Ser
        355                 360                 365             
Ser Ser Lys Glu Pro Val Phe Arg Leu Ser Val Ala Thr Asn Val Ser
    370                 375                 380                 
Ala Thr Leu Thr Phe Asn Thr Ser Lys Ile Thr Gly Phe Leu Lys Pro
385                 390                 395                 400 
Gly Lys Val Lys Val Glu Leu Lys Glu Ser Lys Val Gly Leu Phe Asn
                405                 410                 415     
Ala Glu Leu Leu Glu Ala Leu Leu Asn Tyr Tyr Ile Leu Asn Thr Leu
            420                 425                 430         
Tyr Pro Lys Phe Asn Asp Lys Leu Ala Glu Gly Phe Pro Leu Pro Leu
        435                 440                 445             
Leu Lys Arg Val Gln Leu Tyr Asp Leu Gly Leu Gln Ile His Lys Asp
    450                 455                 460                 
Phe Leu Phe Leu Gly Ala Asn Val Gln Tyr Met Arg Val
465                 470                 475         


<210> 24
<211> 567
<212> PRT
<213> Homo sapiens

<400> 24
Leu Phe Gly Arg Pro Thr Arg Ala Asp Arg Arg Val Leu Gly Thr Glu
 1               5                  10                  15      
Pro Arg Leu Ala Ala Gly Ser Phe Arg Gly Ser Val Lys Arg Ser Ala
            20                  25                  30          
Ala Pro Ala Gly Ala Ser Gln Val Gln Met Lys Thr Ile Gln Leu Lys
        35                  40                  45              
Leu Glu Asn Ile Arg Ser Ile Phe Glu Asn Gln Gln Ala Gly Phe Arg
    50                  55                  60                  
Asn Leu Ala Asp Lys His Val Arg Pro Ile Gln Phe Val Val Pro Thr
65                  70                  75                  80  
Pro Glu Asn Leu Val Thr Ser Gly Thr Pro Phe Phe Ser Ser Lys Gln
                85                  90                  95      
Gly Lys Lys Thr Trp Arg Gln Asn Gln Ser Asn Leu Lys Ile Glu Val
            100                 105                 110         
Val Pro Asp Cys Gln Glu Lys Arg Ser Ser Gly Pro Ser Ser Ser Leu
        115                 120                 125             
Asp Asn Gly Asn Ser Leu Asp Val Leu Lys Asn His Val Leu Asn Glu
    130                 135                 140                 
Leu Ile Gln Thr Glu Arg Val Tyr Val Arg Glu Leu Tyr Thr Val Leu
145                 150                 155                 160 
Leu Gly Tyr Arg Ala Glu Met Asp Asn Pro Glu Met Phe Asp Leu Met
                165                 170                 175     
Pro Pro Leu Leu Arg Asn Lys Lys Asp Ile Leu Phe Gly Asn Met Ala
            180                 185                 190         
Glu Ile Tyr Glu Phe His Asn Asp Ile Phe Leu Ser Ser Leu Glu Asn
        195                 200                 205             
Cys Ala His Ala Pro Glu Arg Val Gly Pro Cys Phe Leu Glu Arg Lys
    210                 215                 220                 
Asp Asp Phe Gln Met Tyr Ala Lys Tyr Cys Gln Asn Lys Pro Arg Ser
225                 230                 235                 240 
Glu Thr Ile Trp Arg Lys Tyr Ser Glu Cys Ala Phe Phe Gln Glu Cys
                245                 250                 255     
Gln Arg Lys Leu Lys His Arg Leu Arg Leu Asp Ser Tyr Leu Leu Lys
            260                 265                 270         
Pro Val Gln Gln Ile Thr Lys Tyr Gln Leu Leu Leu Lys Glu Leu Leu
        275                 280                 285             
Lys Tyr Ser Lys Asp Cys Glu Gly Ser Ala Leu Leu Lys Lys Ala Leu
    290                 295                 300                 
Asp Ala Met Leu Asp Leu Leu Lys Ser Val Asn Asp Ser Met His Gln
305                 310                 315                 320 
Ile Ala Ile Asn Gly Tyr Ile Gly Asn Leu Asn Glu Leu Gly Lys Met
                325                 330                 335     
Ile Met Gln Gly Gly Phe Ser Val Trp Ile Gly His Lys Lys Gly Ala
            340                 345                 350         
Thr Lys Met Lys Asp Leu Ala Arg Phe Lys Pro Met Gln Arg His Leu
        355                 360                 365             
Phe Leu Tyr Glu Lys Ala Ile Val Phe Cys Lys Arg Arg Val Glu Ser
    370                 375                 380                 
Gly Glu Gly Ser Asp Arg Tyr Pro Ser Tyr Ser Phe Lys His Cys Trp
385                 390                 395                 400 
Lys Met Asp Glu Val Gly Ile Thr Glu Tyr Val Lys Gly Asp Asn Arg
                405                 410                 415     
Lys Phe Glu Ile Trp Tyr Gly Glu Lys Glu Glu Val Tyr Ile Val Gln
            420                 425                 430         
Ala Ser Asn Val Asp Val Lys Met Thr Trp Leu Lys Glu Ile Arg Asn
        435                 440                 445             
Ile Leu Leu Lys Gln Gln Glu Leu Leu Thr Val Lys Lys Arg Lys Gln
    450                 455                 460                 
Gln Asp Gln Leu Thr Glu Arg Asp Lys Phe Gln Ile Ser Leu Gln Gln
465                 470                 475                 480 
Asn Asp Glu Lys Gln Gln Gly Ala Phe Ile Ser Thr Glu Glu Thr Glu
                485                 490                 495     
Leu Glu His Thr Ser Thr Val Val Glu Val Cys Glu Ala Ile Ala Ser
            500                 505                 510         
Val Gln Ala Glu Ala Asn Thr Val Trp Thr Glu Ala Ser Gln Ser Ala
        515                 520                 525             
Glu Ile Ser Glu Glu Pro Ala Glu Trp Ser Ser Asn Tyr Phe Tyr Pro
    530                 535                 540                 
Thr Tyr Asp Glu Asn Glu Glu Glu Asn Arg Pro Leu Met Arg Pro Val
545                 550                 555                 560 
Ser Glu Met Ala Leu Leu Tyr
                565         


<210> 25
<211> 531
<212> PRT
<213> Homo sapiens

<400> 25
Met Ser Lys Pro His Ser Glu Ala Gly Thr Ala Phe Ile Gln Thr Gln
 1               5                  10                  15      
Gln Leu His Ala Ala Met Ala Asp Thr Phe Leu Glu His Met Cys Arg
            20                  25                  30          
Leu Asp Ile Asp Ser Pro Pro Ile Thr Ala Arg Asn Thr Gly Ile Ile
        35                  40                  45              
Cys Thr Ile Gly Pro Ala Ser Arg Ser Val Glu Thr Leu Lys Glu Met
    50                  55                  60                  
Ile Lys Ser Gly Met Asn Val Ala Arg Leu Asn Phe Ser His Gly Thr
65                  70                  75                  80  
His Glu Tyr His Ala Glu Thr Ile Lys Asn Val Arg Thr Ala Thr Glu
                85                  90                  95      
Ser Phe Ala Ser Asp Pro Tyr Leu Tyr Arg Pro Val Ala Val Ala Leu
            100                 105                 110         
Asp Thr Lys Gly Pro Glu Ile Arg Thr Gly Leu Ile Lys Gly Ser Gly
        115                 120                 125             
Thr Ala Glu Leu Glu Leu Lys Lys Gly Ala Thr Leu Lys Ile Thr Leu
    130                 135                 140                 
Asp Asn Ala Tyr Met Glu Lys Cys Asp Glu Asn Ile Leu Trp Leu Asp
145                 150                 155                 160 
Tyr Lys Asn Ile Cys Lys Val Val Glu Val Gly Ser Lys Ile Tyr Val
                165                 170                 175     
Asp Asp Gly Leu Ile Ser Leu Gln Val Lys Gln Lys Gly Ala Asp Phe
            180                 185                 190         
Leu Val Thr Glu Val Glu Asn Gly Gly Ser Leu Gly Ser Lys Lys Gly
        195                 200                 205             
Val Asn Leu Pro Gly Ala Ala Val Asp Leu Pro Ala Val Ser Glu Lys
    210                 215                 220                 
Asp Ile Gln Asp Leu Lys Phe Gly Val Glu Gln Asp Val Asp Met Val
225                 230                 235                 240 
Phe Ala Ser Phe Ile Arg Lys Ala Ser Asp Val His Glu Val Arg Lys
                245                 250                 255     
Val Leu Gly Glu Lys Gly Lys Asn Ile Lys Ile Ile Ser Lys Ile Glu
            260                 265                 270         
Asn His Glu Gly Val Arg Arg Phe Asp Glu Ile Leu Glu Ala Ser Asp
        275                 280                 285             
Gly Ile Met Val Ala Arg Gly Asp Leu Gly Ile Glu Ile Pro Ala Glu
    290                 295                 300                 
Lys Val Phe Leu Ala Gln Lys Met Met Ile Gly Arg Cys Asn Arg Ala
305                 310                 315                 320 
Gly Lys Pro Val Ile Cys Ala Thr Gln Met Leu Glu Ser Met Ile Lys
                325                 330                 335     
Lys Pro Arg Pro Thr Arg Ala Glu Gly Ser Asp Val Ala Asn Ala Val
            340                 345                 350         
Leu Asp Gly Ala Asp Cys Ile Met Leu Ser Gly Glu Thr Ala Lys Gly
        355                 360                 365             
Asp Tyr Pro Leu Glu Ala Val Arg Met Gln His Leu Ile Ala Arg Glu
    370                 375                 380                 
Ala Glu Ala Ala Ile Tyr His Leu Gln Leu Phe Glu Glu Leu Arg Arg
385                 390                 395                 400 
Leu Ala Pro Ile Thr Ser Asp Pro Thr Glu Ala Thr Ala Val Gly Ala
                405                 410                 415     
Val Glu Ala Ser Phe Lys Cys Cys Ser Gly Ala Ile Ile Val Leu Thr
            420                 425                 430         
Lys Ser Gly Arg Ser Ala His Gln Val Ala Arg Tyr Arg Pro Arg Ala
        435                 440                 445             
Pro Ile Ile Ala Val Thr Arg Asn Pro Gln Thr Ala Arg Gln Ala His
    450                 455                 460                 
Leu Tyr Arg Gly Ile Phe Pro Val Leu Cys Lys Asp Pro Val Gln Glu
465                 470                 475                 480 
Ala Trp Ala Glu Asp Val Asp Leu Arg Val Asn Phe Ala Met Asn Val
                485                 490                 495     
Gly Lys Ala Arg Gly Phe Phe Lys Lys Gly Asp Val Val Ile Val Leu
            500                 505                 510         
Thr Gly Trp Arg Pro Gly Ser Gly Phe Thr Asn Thr Met Arg Val Val
        515                 520                 525             
Pro Val Pro
    530     


<210> 26
<211> 5032
<212> PRT
<213> Homo sapiens

<400> 26
Met Gly Asp Ala Glu Gly Glu Asp Glu Val Gln Phe Leu Arg Thr Asp
 1               5                  10                  15      
Asp Glu Val Val Leu Gln Cys Ser Ala Thr Val Leu Lys Glu Gln Leu
            20                  25                  30          
Lys Leu Cys Leu Ala Ala Glu Gly Phe Gly Asn Arg Leu Cys Phe Leu
        35                  40                  45              
Glu Pro Thr Ser Asn Ala Gln Asn Val Pro Pro Asp Leu Ala Ile Cys
    50                  55                  60                  
Cys Phe Val Leu Glu Gln Ser Leu Ser Val Arg Ala Leu Gln Glu Met
65                  70                  75                  80  
Leu Ala Asn Thr Val Glu Ala Gly Val Glu Ser Ser Gln Gly Gly Gly
                85                  90                  95      
His Arg Thr Leu Leu Tyr Gly His Ala Ile Leu Leu Arg His Ala His
            100                 105                 110         
Ser Arg Met Tyr Leu Ser Cys Leu Thr Thr Ser Arg Ser Met Thr Asp
        115                 120                 125             
Lys Leu Ala Phe Asp Val Gly Leu Gln Glu Asp Ala Thr Gly Glu Ala
    130                 135                 140                 
Cys Trp Trp Thr Met His Pro Ala Ser Lys Gln Arg Ser Glu Gly Glu
145                 150                 155                 160 
Lys Val Arg Val Gly Asp Asp Ile Ile Leu Val Ser Val Ser Ser Glu
                165                 170                 175     
Arg Tyr Leu His Leu Ser Thr Ala Ser Gly Glu Leu Gln Val Asp Ala
            180                 185                 190         
Ser Phe Met Gln Thr Leu Trp Asn Met Asn Pro Ile Cys Ser Arg Cys
        195                 200                 205             
Glu Glu Gly Phe Val Thr Gly Gly His Val Leu Arg Leu Phe His Gly
    210                 215                 220                 
His Met Asp Glu Cys Leu Thr Ile Ser Pro Ala Asp Ser Asp Asp Gln
225                 230                 235                 240 
Arg Arg Leu Val Tyr Tyr Glu Gly Gly Ala Val Cys Thr His Ala Arg
                245                 250                 255     
Ser Leu Trp Arg Leu Glu Pro Leu Arg Ile Ser Trp Ser Gly Ser His
            260                 265                 270         
Leu Arg Trp Gly Gln Pro Leu Arg Val Arg His Val Thr Thr Gly Gln
        275                 280                 285             
Tyr Leu Ala Leu Thr Glu Asp Gln Gly Leu Val Val Val Asp Ala Ser
    290                 295                 300                 
Lys Ala His Thr Lys Ala Thr Ser Phe Cys Phe Arg Ile Ser Lys Glu
305                 310                 315                 320 
Lys Leu Asp Val Ala Pro Lys Arg Asp Val Glu Gly Met Gly Pro Pro
                325                 330                 335     
Glu Ile Lys Tyr Gly Glu Ser Leu Cys Phe Val Gln His Val Ala Ser
            340                 345                 350         
Gly Leu Trp Leu Thr Tyr Ala Ala Pro Asp Pro Lys Ala Leu Arg Leu
        355                 360                 365             
Gly Val Leu Lys Lys Lys Ala Met Leu His Gln Glu Gly His Met Asp
    370                 375                 380                 
Asp Ala Leu Ser Leu Thr Arg Cys Gln Gln Glu Glu Ser Gln Ala Ala
385                 390                 395                 400 
Arg Met Ile His Ser Thr Asn Gly Leu Tyr Asn Gln Phe Ile Lys Ser
                405                 410                 415     
Leu Asp Ser Phe Ser Gly Lys Pro Arg Gly Ser Gly Pro Pro Ala Gly
            420                 425                 430         
Thr Ala Leu Pro Ile Glu Gly Val Ile Leu Ser Leu Gln Asp Leu Ile
        435                 440                 445             
Ile Tyr Phe Glu Pro Pro Ser Glu Asp Leu Gln His Glu Glu Lys Gln
    450                 455                 460                 
Ser Lys Leu Arg Ser Leu Arg Asn Arg Gln Ser Leu Phe Gln Glu Glu
465                 470                 475                 480 
Gly Met Leu Ser Met Val Leu Asn Cys Ile Asp Arg Leu Asn Val Tyr
                485                 490                 495     
Thr Thr Ala Ala His Phe Ala Glu Phe Ala Gly Glu Glu Ala Ala Glu
            500                 505                 510         
Ser Trp Lys Glu Ile Val Asn Leu Leu Tyr Glu Leu Leu Ala Ser Leu
        515                 520                 525             
Ile Arg Gly Asn Arg Ser Asn Cys Ala Leu Phe Ser Thr Asn Leu Asp
    530                 535                 540                 
Trp Leu Val Ser Lys Leu Asp Arg Leu Glu Ala Ser Ser Gly Ile Leu
545                 550                 555                 560 
Glu Val Leu Tyr Cys Val Leu Ile Glu Ser Pro Glu Val Leu Asn Ile
                565                 570                 575     
Ile Gln Glu Asn His Ile Lys Ser Ile Ile Ser Leu Leu Asp Lys His
            580                 585                 590         
Gly Arg Asn His Lys Val Leu Asp Val Leu Cys Ser Leu Cys Val Cys
        595                 600                 605             
Asn Gly Val Ala Val Arg Ser Asn Gln Asp Leu Ile Thr Glu Asn Leu
    610                 615                 620                 
Leu Pro Gly Arg Glu Leu Leu Leu Gln Thr Asn Leu Ile Asn Tyr Val
625                 630                 635                 640 
Thr Ser Ile Arg Pro Asn Ile Phe Val Gly Arg Ala Glu Gly Thr Thr
                645                 650                 655     
Gln Tyr Ser Lys Trp Tyr Phe Glu Val Met Val Asp Glu Val Thr Pro
            660                 665                 670         
Phe Leu Thr Ala Gln Ala Thr His Leu Arg Val Gly Trp Ala Leu Thr
        675                 680                 685             
Glu Gly Tyr Thr Pro Tyr Pro Gly Ala Gly Glu Gly Trp Gly Gly Asn
    690                 695                 700                 
Gly Val Gly Asp Asp Leu Tyr Ser Tyr Gly Phe Asp Gly Leu His Leu
705                 710                 715                 720 
Trp Thr Gly His Val Ala Arg Pro Val Thr Ser Pro Gly Gln His Leu
                725                 730                 735     
Leu Ala Pro Glu Asp Val Ile Ser Cys Cys Leu Asp Leu Ser Val Pro
            740                 745                 750         
Ser Ile Ser Phe Arg Ile Asn Gly Cys Pro Val Gln Gly Val Phe Glu
        755                 760                 765             
Ser Phe Asn Leu Asp Gly Leu Phe Phe Pro Val Val Ser Phe Ser Ala
    770                 775                 780                 
Gly Val Lys Val Arg Phe Leu Leu Gly Gly Arg His Gly Glu Phe Lys
785                 790                 795                 800 
Phe Leu Pro Pro Pro Gly Tyr Ala Pro Cys His Glu Ala Val Leu Pro
                805                 810                 815     
Arg Glu Arg Leu His Leu Glu Pro Ile Lys Glu Tyr Arg Arg Glu Gly
            820                 825                 830         
Pro Arg Gly Pro His Leu Val Gly Pro Ser Arg Cys Leu Ser His Thr
        835                 840                 845             
Asp Phe Val Pro Cys Pro Val Asp Thr Val Gln Ile Val Leu Pro Pro
    850                 855                 860                 
His Leu Glu Arg Ile Arg Glu Lys Leu Ala Glu Asn Ile His Glu Leu
865                 870                 875                 880 
Trp Ala Leu Thr Arg Ile Glu Gln Gly Trp Thr Tyr Gly Pro Val Arg
                885                 890                 895     
Asp Asp Asn Lys Arg Leu His Pro Cys Leu Val Asp Phe His Ser Leu
            900                 905                 910         
Pro Glu Pro Glu Arg Asn Tyr Asn Leu Gln Met Ser Gly Glu Thr Leu
        915                 920                 925             
Lys Thr Leu Leu Ala Leu Gly Cys His Val Gly Met Ala Asp Glu Lys
    930                 935                 940                 
Ala Glu Asp Asn Leu Lys Lys Thr Lys Leu Pro Lys Thr Tyr Met Met
945                 950                 955                 960 
Ser Asn Gly Tyr Lys Pro Ala Pro Leu Asp Leu Ser His Val Arg Leu
                965                 970                 975     
Thr Pro Ala Gln Thr Thr Leu Val Asp Arg Leu Ala Glu Asn Gly His
            980                 985                 990         
Asn Val Trp Ala Arg Asp Arg Val Gly Gln Gly Trp Ser Tyr Ser Ala
        995                 1000                1005            
Val Gln Asp Ile Pro Ala Arg Arg Asn Pro Arg Leu Val Pro Tyr Arg
    1010                1015                1020                
Leu Leu Asp Glu Ala Thr Lys Arg Ser Asn Arg Asp Ser Leu Cys Gln
1025                1030                1035                1040
Ala Val Arg Thr Leu Leu Gly Tyr Gly Tyr Asn Ile Glu Pro Pro Asp
                1045                1050                1055    
Gln Glu Pro Ser Gln Val Glu Asn Gln Ser Arg Cys Asp Arg Val Arg
            1060                1065                1070        
Ile Phe Arg Ala Glu Lys Ser Tyr Thr Val Gln Ser Gly Arg Trp Tyr
        1075                1080                1085            
Phe Glu Phe Glu Ala Val Thr Thr Gly Glu Met Arg Val Gly Trp Ala
    1090                1095                1100                
Arg Pro Glu Leu Arg Pro Asp Val Glu Leu Gly Ala Asp Glu Leu Ala
1105                1110                1115                1120
Tyr Val Phe Asn Gly His Arg Gly Gln Arg Trp His Leu Gly Ser Glu
                1125                1130                1135    
Pro Phe Gly Arg Pro Trp Gln Pro Gly Asp Val Val Gly Cys Met Ile
            1140                1145                1150        
Asp Leu Thr Glu Asn Thr Ile Ile Phe Thr Leu Asn Gly Glu Val Leu
        1155                1160                1165            
Met Ser Asp Ser Gly Ser Glu Thr Ala Phe Arg Glu Ile Glu Ile Gly
    1170                1175                1180                
Asp Gly Phe Leu Pro Val Cys Ser Leu Gly Pro Gly Gln Val Gly His
1185                1190                1195                1200
Leu Asn Leu Gly Gln Asp Val Ser Ser Leu Arg Phe Phe Ala Ile Cys
                1205                1210                1215    
Gly Leu Gln Glu Gly Phe Glu Pro Phe Ala Ile Asn Met Gln Arg Pro
            1220                1225                1230        
Val Thr Thr Trp Phe Ser Lys Gly Leu Pro Gln Phe Glu Pro Val Pro
        1235                1240                1245            
Leu Glu His Pro His Tyr Glu Val Ser Arg Val Asp Gly Thr Val Asp
    1250                1255                1260                
Thr Pro Pro Cys Leu Arg Leu Thr His Arg Thr Trp Gly Ser Gln Asn
1265                1270                1275                1280
Ser Leu Val Glu Met Leu Phe Leu Arg Leu Ser Leu Pro Val Gln Phe
                1285                1290                1295    
His Gln His Phe Arg Cys Thr Ala Gly Ala Thr Pro Leu Ala Pro Pro
            1300                1305                1310        
Gly Leu Gln Pro Pro Ala Glu Asp Glu Ala Arg Ala Ala Glu Pro Asp
        1315                1320                1325            
Pro Asp Tyr Glu Asn Leu Arg Arg Ser Ala Gly Gly Trp Ser Glu Ala
    1330                1335                1340                
Glu Asn Gly Lys Glu Gly Thr Ala Lys Glu Gly Ala Pro Gly Gly Thr
1345                1350                1355                1360
Pro Gln Ala Gly Arg Gly Ala Pro Ala Arg Ala Glu Asn Glu Lys Asp
                1365                1370                1375    
Ala Thr Thr Glu Lys Asn Lys Lys Arg Gly Phe Leu Phe Lys Ala Lys
            1380                1385                1390        
Lys Val Ala Met Met Thr Gln Pro Pro Ala Thr Pro Thr Leu Pro Arg
        1395                1400                1405            
Leu Pro His Asp Val Val Pro Ala Asp Asn Arg Asp Asp Pro Glu Ile
    1410                1415                1420                
Ile Leu Asn Thr Thr Thr Tyr Tyr Tyr Ser Val Arg Val Phe Ala Gly
1425                1430                1435                1440
Gln Glu Pro Ser Cys Val Trp Ala Gly Trp Val Thr Pro Asp Tyr His
                1445                1450                1455    
Gln His Asp Met Ser Phe Asp Leu Ser Lys Val Arg Val Val Thr Val
            1460                1465                1470        
Thr Met Gly Asp Glu Gln Gly Asn Val His Ser Ser Leu Lys Cys Ser
        1475                1480                1485            
Asn Cys Tyr Met Val Trp Gly Gly Asp Phe Val Ser Pro Gly Gln Gln
    1490                1495                1500                
Gly Arg Ile Ser His Thr Asp Leu Val Ile Gly Cys Leu Val Asp Leu
1505                1510                1515                1520
Ala Thr Gly Leu Met Thr Phe Thr Ala Asn Gly Lys Glu Ser Asn Thr
                1525                1530                1535    
Phe Phe Gln Val Glu Pro Asn Thr Lys Leu Phe Pro Ala Val Phe Val
            1540                1545                1550        
Leu Pro Thr His Gln Asn Val Ile Gln Phe Glu Leu Gly Lys Gln Lys
        1555                1560                1565            
Asn Ile Met Pro Leu Ser Ala Ala Met Phe Gln Ser Glu Arg Lys Asn
    1570                1575                1580                
Pro Ala Pro Gln Cys Pro Pro Arg Leu Glu Met Gln Met Leu Met Pro
1585                1590                1595                1600
Val Ser Trp Ser Arg Met Pro Asn His Phe Leu Gln Val Glu Thr Arg
                1605                1610                1615    
Arg Ala Gly Glu Arg Leu Gly Trp Ala Val Gln Cys Gln Glu Pro Leu
            1620                1625                1630        
Thr Met Met Ala Leu His Ile Pro Glu Glu Asn Arg Cys Met Asp Ile
        1635                1640                1645            
Leu Glu Leu Ser Glu Arg Leu Asp Leu Gln Arg Phe His Ser His Thr
    1650                1655                1660                
Leu Arg Leu Tyr Arg Ala Val Cys Ala Leu Gly Asn Asn Arg Val Ala
1665                1670                1675                1680
His Ala Leu Cys Ser His Val Asp Gln Ala Gln Leu Leu His Ala Leu
                1685                1690                1695    
Glu Asp Ala His Leu Pro Gly Pro Leu Arg Ala Gly Tyr Tyr Asp Leu
            1700                1705                1710        
Leu Ile Ser Ile His Leu Glu Ser Ala Cys Arg Ser Arg Arg Ser Met
        1715                1720                1725            
Leu Ser Glu Tyr Ile Val Pro Leu Thr Pro Glu Thr Arg Ala Ile Thr
    1730                1735                1740                
Leu Phe Pro Pro Gly Arg Ser Thr Glu Asn Gly His Pro Arg His Gly
1745                1750                1755                1760
Leu Pro Gly Val Gly Val Thr Thr Ser Leu Arg Pro Pro His His Phe
                1765                1770                1775    
Ser Pro Pro Cys Phe Val Ala Ala Leu Pro Ala Ala Gly Ala Ala Glu
            1780                1785                1790        
Ala Pro Ala Arg Leu Ser Pro Ala Ile Pro Leu Glu Ala Leu Arg Asp
        1795                1800                1805            
Lys Ala Leu Arg Met Leu Gly Glu Ala Val Arg Asp Gly Gly Gln His
    1810                1815                1820                
Ala Arg Asp Pro Val Gly Ala Ser Val Glu Phe Gln Phe Val Pro Val
1825                1830                1835                1840
Leu Lys Leu Val Ser Thr Leu Leu Val Met Gly Ile Phe Gly Asp Glu
                1845                1850                1855    
Asp Val Lys Gln Ile Leu Lys Met Ile Glu Pro Glu Val Phe Thr Glu
            1860                1865                1870        
Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu Gly Glu Glu Glu Asp Glu
        1875                1880                1885            
Glu Glu Lys Glu Glu Asp Glu Glu Glu Thr Ala Gln Glu Lys Glu Asp
    1890                1895                1900                
Glu Glu Lys Glu Glu Glu Glu Ala Ala Glu Gly Glu Lys Glu Glu Gly
1905                1910                1915                1920
Leu Glu Glu Gly Leu Leu Gln Met Lys Leu Pro Glu Ser Val Lys Leu
                1925                1930                1935    
Gln Met Cys His Leu Leu Glu Tyr Phe Cys Asp Gln Glu Leu Gln His
            1940                1945                1950        
Arg Val Glu Ser Leu Ala Ala Phe Ala Glu Arg Tyr Val Asp Lys Leu
        1955                1960                1965            
Gln Ala Asn Gln Arg Ser Arg Tyr Gly Leu Leu Ile Lys Ala Phe Ser
    1970                1975                1980                
Met Thr Ala Ala Glu Thr Ala Arg Arg Thr Arg Glu Phe Arg Ser Pro
1985                1990                1995                2000
Pro Gln Glu Gln Ile Asn Met Leu Leu Gln Phe Lys Asp Gly Thr Asp
                2005                2010                2015    
Glu Glu Asp Cys Pro Leu Pro Glu Glu Ile Arg Gln Asp Leu Leu Asp
            2020                2025                2030        
Phe His Gln Asp Leu Leu Ala His Cys Gly Ile Gln Leu Asp Gly Glu
        2035                2040                2045            
Glu Glu Glu Pro Glu Glu Glu Thr Thr Leu Gly Ser Arg Leu Met Ser
    2050                2055                2060                
Leu Leu Glu Lys Val Arg Leu Val Lys Lys Lys Glu Glu Lys Pro Glu
2065                2070                2075                2080
Glu Glu Arg Ser Ala Glu Glu Ser Lys Pro Arg Ser Leu Gln Glu Leu
                2085                2090                2095    
Val Ser His Met Val Val Arg Trp Ala Gln Glu Asp Phe Val Gln Ser
            2100                2105                2110        
Pro Glu Leu Val Arg Ala Met Phe Ser Leu Leu His Arg Gln Tyr Asp
        2115                2120                2125            
Gly Leu Gly Glu Leu Leu Arg Ala Leu Pro Arg Ala Tyr Thr Ile Ser
    2130                2135                2140                
Pro Ser Ser Val Glu Asp Thr Met Ser Leu Leu Glu Cys Leu Gly Gln
2145                2150                2155                2160
Ile Arg Ser Leu Leu Ile Val Gln Met Gly Pro Gln Glu Glu Asn Leu
                2165                2170                2175    
Met Ile Gln Ser Ile Gly Asn Ile Met Asn Asn Lys Val Phe Tyr Gln
            2180                2185                2190        
His Pro Asn Leu Met Arg Ala Leu Gly Met His Glu Thr Val Met Glu
        2195                2200                2205            
Val Met Val Asn Val Leu Gly Gly Gly Glu Ser Lys Glu Ile Arg Phe
    2210                2215                2220                
Pro Lys Met Val Thr Ser Cys Cys Arg Phe Leu Cys Tyr Phe Cys Arg
2225                2230                2235                2240
Ile Ser Arg Gln Asn Gln Arg Ser Met Phe Asp His Leu Ser Tyr Leu
                2245                2250                2255    
Leu Glu Asn Ser Gly Ile Gly Leu Gly Met Gln Gly Ser Thr Pro Leu
            2260                2265                2270        
Asp Val Ala Ala Ala Ser Val Ile Asp Asn Asn Glu Leu Ala Leu Ala
        2275                2280                2285            
Leu Gln Glu Gln Asp Leu Glu Lys Val Val Ser Tyr Leu Ala Gly Cys
    2290                2295                2300                
Gly Leu Gln Ser Cys Pro Met Leu Val Ala Lys Gly Tyr Pro Asp Ile
2305                2310                2315                2320
Gly Trp Lys Pro Cys Gly Gly Glu Arg Tyr Leu Asp Phe Leu Arg Phe
                2325                2330                2335    
Ala Val Phe Val Asn Gly Glu Ser Val Glu Glu Asn Ala Asn Val Val
            2340                2345                2350        
Val Arg Leu Leu Ile Arg Lys Pro Glu Cys Phe Gly Pro Ala Leu Arg
        2355                2360                2365            
Gly Glu Gly Gly Ser Gly Leu Leu Ala Ala Ile Glu Glu Ala Ile Arg
    2370                2375                2380                
Ile Ser Glu Asp Pro Ala Arg Asp Gly Pro Gly Ile Arg Arg Asp Arg
2385                2390                2395                2400
Arg Arg Glu His Phe Gly Glu Glu Pro Pro Glu Glu Asn Arg Val His
                2405                2410                2415    
Leu Gly His Ala Ile Met Ser Phe Tyr Ala Ala Leu Ile Asp Leu Leu
            2420                2425                2430        
Gly Arg Cys Ala Pro Glu Met His Leu Ile Gln Ala Gly Lys Gly Glu
        2435                2440                2445            
Ala Leu Arg Ile Arg Ala Ile Leu Arg Ser Leu Val Pro Leu Glu Asp
    2450                2455                2460                
Leu Val Gly Ile Ile Ser Leu Pro Leu Gln Ile Pro Thr Leu Gly Lys
2465                2470                2475                2480
Asp Gly Ala Leu Val Gln Pro Lys Met Ser Ala Ser Phe Val Pro Asp
                2485                2490                2495    
His Lys Ala Ser Met Val Leu Phe Leu Asp Arg Val Tyr Gly Ile Glu
            2500                2505                2510        
Asn Gln Asp Phe Leu Leu His Val Leu Asp Val Gly Phe Leu Pro Asp
        2515                2520                2525            
Met Arg Ala Ala Ala Ser Leu Asp Thr Ala Thr Phe Ser Thr Thr Glu
    2530                2535                2540                
Met Ala Leu Ala Val Asn Arg Tyr Leu Cys Leu Ala Val Leu Pro Leu
2545                2550                2555                2560
Ile Thr Lys Cys Ala Pro Leu Phe Ala Gly Thr Glu His Arg Ala Ile
                2565                2570                2575    
Met Val Asp Ser Met Leu His Thr Val Tyr Arg Leu Ser Arg Gly Arg
            2580                2585                2590        
Ser Leu Thr Lys Ala Gln Arg Asp Val Ile Glu Asp Cys Leu Met Ser
        2595                2600                2605            
Leu Cys Arg Tyr Ile Arg Pro Ser Met Leu Gln His Leu Leu Arg Arg
    2610                2615                2620                
Leu Val Phe Asp Val Pro Ile Leu Asn Glu Phe Ala Lys Met Pro Leu
2625                2630                2635                2640
Lys Leu Leu Thr Asn His Tyr Glu Arg Cys Trp Lys Tyr Tyr Cys Leu
                2645                2650                2655    
Pro Thr Gly Trp Ala Asn Phe Gly Val Thr Ser Glu Glu Glu Leu His
            2660                2665                2670        
Leu Thr Arg Lys Leu Phe Trp Gly Ile Phe Asp Ser Leu Ala His Lys
        2675                2680                2685            
Lys Tyr Asp Pro Glu Leu Tyr Arg Met Ala Met Pro Cys Leu Cys Ala
    2690                2695                2700                
Ile Ala Gly Ala Leu Pro Pro Asp Tyr Val Asp Ala Ser Tyr Ser Ser
2705                2710                2715                2720
Lys Ala Glu Lys Lys Ala Thr Val Asp Ala Glu Gly Asn Phe Asp Pro
                2725                2730                2735    
Arg Pro Val Glu Thr Leu Asn Val Ile Ile Pro Glu Lys Leu Asp Ser
            2740                2745                2750        
Phe Ile Asn Lys Phe Ala Glu Tyr Thr His Glu Lys Trp Ala Phe Asp
        2755                2760                2765            
Lys Ile Gln Asn Asn Trp Ser Tyr Gly Glu Asn Ile Asp Glu Glu Leu
    2770                2775                2780                
Lys Thr His Pro Met Leu Arg Pro Tyr Lys Thr Phe Ser Glu Lys Asp
2785                2790                2795                2800
Lys Glu Ile Tyr Arg Trp Pro Ile Lys Glu Ser Leu Lys Ala Met Ile
                2805                2810                2815    
Ala Trp Glu Trp Thr Ile Glu Lys Ala Arg Glu Gly Glu Glu Glu Lys
            2820                2825                2830        
Thr Glu Lys Lys Lys Thr Ala Lys Ile Ser Gln Ser Ala Gln Thr Tyr
        2835                2840                2845            
Asp Pro Arg Glu Gly Tyr Asn Pro Gln Pro Pro Asp Leu Ser Ala Val
    2850                2855                2860                
Thr Leu Ser Arg Glu Leu Gln Ala Met Ala Glu Gln Leu Ala Glu Asn
2865                2870                2875                2880
Tyr His Asn Thr Trp Gly Arg Lys Lys Lys Gln Glu Leu Glu Ala Lys
                2885                2890                2895    
Gly Gly Gly Thr His Pro Leu Leu Val Pro Tyr Asp Thr Leu Thr Ala
            2900                2905                2910        
Lys Glu Lys Ala Arg Asp Arg Glu Lys Ala Gln Glu Leu Leu Lys Phe
        2915                2920                2925            
Leu Gln Met Asn Gly Tyr Ala Val Thr Arg Gly Leu Lys Asp Met Glu
    2930                2935                2940                
Leu Asp Ser Ser Ser Ile Glu Lys Arg Phe Ala Phe Gly Phe Leu Gln
2945                2950                2955                2960
Gln Leu Leu Arg Trp Met Asp Ile Ser Gln Glu Phe Ile Ala His Leu
                2965                2970                2975    
Glu Ala Val Val Ser Ser Gly Arg Val Glu Lys Ser Pro His Glu Gln
            2980                2985                2990        
Glu Ile Lys Phe Phe Ala Lys Ile Leu Leu Pro Leu Ile Asn Gln Tyr
        2995                3000                3005            
Phe Thr Asn His Cys Leu Tyr Phe Leu Ser Thr Pro Ala Lys Val Leu
    3010                3015                3020                
Gly Ser Gly Gly His Ala Ser Asn Lys Glu Lys Glu Met Ile Thr Ser
3025                3030                3035                3040
Leu Phe Cys Lys Leu Ala Ala Leu Val Arg His Arg Val Ser Leu Phe
                3045                3050                3055    
Gly Thr Asp Ala Pro Ala Val Val Asn Cys Leu His Ile Leu Ala Arg
            3060                3065                3070        
Ser Leu Asp Ala Arg Thr Val Met Lys Ser Gly Pro Glu Ile Val Lys
        3075                3080                3085            
Ala Gly Leu Arg Ser Phe Phe Glu Ser Ala Ser Glu Asp Ile Glu Lys
    3090                3095                3100                
Met Val Glu Asn Leu Arg Leu Gly Lys Val Ser Gln Ala Arg Thr Gln
3105                3110                3115                3120
Val Lys Gly Val Gly Gln Asn Leu Thr Tyr Thr Thr Val Ala Leu Leu
                3125                3130                3135    
Pro Val Leu Thr Thr Leu Phe Gln His Ile Ala Gln His Gln Phe Gly
            3140                3145                3150        
Asp Asp Val Ile Leu Asp Asp Val Gln Val Ser Cys Tyr Arg Thr Leu
        3155                3160                3165            
Cys Ser Ile Tyr Ser Leu Gly Thr Thr Lys Asn Thr Tyr Val Glu Lys
    3170                3175                3180                
Leu Arg Pro Ala Leu Gly Glu Cys Leu Ala Arg Leu Ala Ala Ala Met
3185                3190                3195                3200
Pro Val Ala Phe Leu Glu Pro Gln Leu Asn Glu Tyr Asn Ala Cys Ser
                3205                3210                3215    
Val Tyr Thr Thr Lys Ser Pro Arg Glu Arg Ala Ile Leu Gly Leu Pro
            3220                3225                3230        
Asn Ser Val Glu Glu Met Cys Pro Asp Ile Pro Val Leu Glu Arg Leu
        3235                3240                3245            
Met Ala Asp Ile Gly Gly Leu Ala Glu Ser Gly Ala Arg Tyr Thr Glu
    3250                3255                3260                
Met Pro His Val Ile Glu Ile Thr Leu Pro Met Leu Cys Ser Tyr Leu
3265                3270                3275                3280
Pro Arg Trp Trp Glu Arg Gly Pro Glu Ala Pro Pro Ser Ala Leu Pro
                3285                3290                3295    
Ala Gly Ala Pro Pro Pro Cys Thr Ala Val Thr Ser Asp His Leu Asn
            3300                3305                3310        
Ser Leu Leu Gly Asn Ile Leu Arg Ile Ile Val Asn Asn Leu Gly Ile
        3315                3320                3325            
Asp Glu Ala Ser Trp Met Lys Arg Leu Ala Val Phe Ala Gln Pro Ile
    3330                3335                3340                
Val Ser Arg Ala Arg Pro Glu Leu Leu Gln Ser His Phe Ile Pro Thr
3345                3350                3355                3360
Ile Gly Arg Leu Arg Lys Arg Ala Gly Lys Val Val Ser Glu Glu Glu
                3365                3370                3375    
Gln Leu Ala Leu Glu Ala Lys Ala Glu Ala Gln Glu Gly Glu Leu Leu
            3380                3385                3390        
Val Arg Asp Glu Phe Ser Val Leu Cys Arg Asp Leu Tyr Ala Leu Tyr
        3395                3400                3405            
Pro Leu Leu Ile Arg Tyr Val Asp Asn Asn Arg Ala Gln Trp Leu Thr
    3410                3415                3420                
Glu Pro Asn Pro Ser Ala Glu Glu Leu Phe Arg Met Val Gly Glu Ile
3425                3430                3435                3440
Phe Ile Tyr Trp Ser Lys Ser His Asn Phe Lys Arg Glu Glu Gln Asn
                3445                3450                3455    
Phe Val Val Gln Asn Glu Ile Asn Asn Met Ser Phe Leu Thr Ala Asp
            3460                3465                3470        
Asn Lys Ser Lys Met Ala Lys Ser Gly Gly Ser Asp Gln Glu Arg Thr
        3475                3480                3485            
Lys Lys Lys Arg Arg Gly Asp Arg Tyr Ser Val Gln Thr Ser Leu Ile
    3490                3495                3500                
Val Ala Thr Leu Lys Lys Met Leu Pro Ile Gly Leu Asn Met Cys Ala
3505                3510                3515                3520
Pro Thr Asp Gln Asp Leu Ile Thr Leu Ala Lys Thr Arg Tyr Ala Leu
                3525                3530                3535    
Lys Asp Thr Asp Glu Glu Val Arg Glu Phe Leu His Asn Asn Leu His
            3540                3545                3550        
Leu Gln Gly Lys Val Glu Gly Ser Pro Ser Leu Arg Trp Gln Met Ala
        3555                3560                3565            
Leu Tyr Arg Gly Val Pro Gly Arg Glu Glu Asp Ala Asp Asp Pro Glu
    3570                3575                3580                
Lys Ile Val Arg Arg Val Gln Glu Val Ser Ala Val Leu Tyr Tyr Leu
3585                3590                3595                3600
Asp Gln Thr Glu His Pro Tyr Lys Ser Lys Lys Ala Val Trp His Lys
                3605                3610                3615    
Leu Leu Ser Lys Gln Arg Arg Arg Ala Val Val Ala Cys Phe Arg Met
            3620                3625                3630        
Thr Pro Leu Tyr Asn Leu Pro Thr His Arg Ala Cys Asn Met Phe Leu
        3635                3640                3645            
Glu Ser Tyr Lys Ala Ala Trp Ile Leu Thr Glu Asp His Ser Phe Glu
    3650                3655                3660                
Asp Arg Met Ile Asp Asp Leu Ser Lys Ala Gly Glu Gln Glu Glu Glu
3665                3670                3675                3680
Glu Glu Glu Val Glu Glu Lys Lys Pro Asp Pro Leu His Gln Leu Val
                3685                3690                3695    
Leu His Phe Ser Arg Thr Ala Leu Thr Glu Lys Ser Lys Leu Asp Glu
            3700                3705                3710        
Asp Tyr Leu Tyr Met Ala Tyr Ala Asp Ile Met Ala Lys Ser Cys His
        3715                3720                3725            
Leu Glu Glu Gly Gly Glu Asn Gly Glu Ala Glu Glu Glu Val Glu Val
    3730                3735                3740                
Ser Phe Glu Glu Lys Gln Met Glu Lys Gln Arg Leu Leu Tyr Gln Gln
3745                3750                3755                3760
Ala Arg Leu His Thr Arg Gly Ala Ala Glu Met Val Leu Gln Met Ile
                3765                3770                3775    
Ser Ala Cys Lys Gly Glu Thr Gly Ala Met Val Ser Ser Thr Leu Lys
            3780                3785                3790        
Leu Gly Ile Ser Ile Leu Asn Gly Gly Asn Ala Glu Val Gln Gln Lys
        3795                3800                3805            
Met Leu Asp Tyr Leu Lys Asp Lys Lys Glu Val Gly Phe Phe Gln Ser
    3810                3815                3820                
Ile Gln Ala Leu Met Gln Thr Cys Ser Val Leu Asp Leu Asn Ala Phe
3825                3830                3835                3840
Glu Arg Gln Asn Lys Ala Glu Gly Leu Gly Met Val Asn Glu Asp Gly
                3845                3850                3855    
Thr Val Ile Asn Arg Gln Asn Gly Glu Lys Val Met Ala Asp Asp Glu
            3860                3865                3870        
Phe Thr Gln Asp Leu Phe Arg Phe Leu Gln Leu Leu Cys Glu Gly His
        3875                3880                3885            
Asn Asn Asp Phe Gln Asn Tyr Leu Arg Thr Gln Thr Gly Asn Thr Thr
    3890                3895                3900                
Thr Ile Asn Ile Ile Ile Cys Thr Val Asp Tyr Leu Leu Arg Leu Gln
3905                3910                3915                3920
Glu Ser Ile Ser Asp Phe Tyr Trp Tyr Tyr Ser Gly Lys Asp Val Ile
                3925                3930                3935    
Glu Glu Gln Gly Lys Arg Asn Phe Ser Lys Ala Met Ser Val Ala Lys
            3940                3945                3950        
Gln Val Phe Asn Ser Leu Thr Glu Tyr Ile Gln Gly Pro Cys Thr Gly
        3955                3960                3965            
Asn Gln Gln Ser Leu Ala His Ser Arg Leu Trp Asp Ala Val Val Gly
    3970                3975                3980                
Phe Leu His Val Phe Ala His Met Met Met Lys Leu Ala Gln Asp Ser
3985                3990                3995                4000
Ser Gln Ile Glu Leu Leu Lys Glu Leu Leu Asp Leu Gln Lys Asp Met
                4005                4010                4015    
Val Val Met Leu Leu Ser Leu Leu Glu Gly Asn Val Val Asn Gly Met
            4020                4025                4030        
Ile Ala Arg Gln Met Val Asp Met Leu Val Glu Ser Ser Ser Asn Val
        4035                4040                4045            
Glu Met Ile Leu Lys Phe Phe Asp Met Phe Leu Lys Leu Lys Asp Ile
    4050                4055                4060                
Val Gly Ser Glu Ala Phe Gln Asp Tyr Val Thr Asp Pro Arg Gly Leu
4065                4070                4075                4080
Ile Ser Lys Lys Asp Phe Gln Lys Ala Met Asp Ser Gln Lys Gln Phe
                4085                4090                4095    
Ser Gly Pro Glu Ile Gln Phe Leu Leu Ser Cys Ser Glu Ala Asp Glu
            4100                4105                4110        
Asn Glu Met Ile Asn Cys Glu Glu Phe Ala Asn Arg Phe Gln Glu Pro
        4115                4120                4125            
Ala Arg Asp Ile Gly Phe Asn Val Ala Val Leu Leu Thr Asn Leu Ser
    4130                4135                4140                
Glu His Val Pro His Asp Pro Arg Leu His Asn Phe Leu Glu Leu Ala
4145                4150                4155                4160
Glu Ser Ile Leu Glu Tyr Phe Arg Pro Tyr Leu Gly Arg Ile Glu Ile
                4165                4170                4175    
Met Gly Ala Ser Arg Arg Ile Glu Arg Ile Tyr Phe Glu Ile Ser Glu
            4180                4185                4190        
Thr Asn Arg Ala Gln Trp Glu Met Pro Gln Val Lys Glu Ser Lys Arg
        4195                4200                4205            
Gln Phe Ile Phe Asp Val Val Asn Glu Gly Gly Glu Ala Glu Lys Met
    4210                4215                4220                
Glu Leu Phe Val Ser Phe Cys Glu Asp Thr Ile Phe Glu Met Gln Ile
4225                4230                4235                4240
Ala Ala Gln Ile Ser Glu Pro Glu Gly Glu Pro Glu Thr Asp Glu Asp
                4245                4250                4255    
Glu Gly Ala Gly Ala Ala Glu Ala Gly Ala Glu Gly Ala Glu Glu Gly
            4260                4265                4270        
Ala Ala Gly Leu Glu Gly Thr Ala Ala Thr Ala Ala Ala Gly Ala Thr
        4275                4280                4285            
Ala Arg Val Val Ala Ala Ala Gly Arg Ala Leu Arg Gly Leu Ser Tyr
    4290                4295                4300                
Arg Ser Leu Arg Arg Arg Val Arg Arg Leu Arg Arg Leu Thr Ala Arg
4305                4310                4315                4320
Glu Ala Ala Thr Ala Val Ala Ala Leu Leu Trp Ala Ala Val Thr Arg
                4325                4330                4335    
Ala Gly Ala Ala Gly Ala Gly Ala Ala Ala Gly Ala Leu Gly Leu Leu
            4340                4345                4350        
Trp Gly Ser Leu Phe Gly Gly Gly Leu Val Glu Gly Ala Lys Lys Val
        4355                4360                4365            
Thr Val Thr Glu Leu Leu Ala Gly Met Pro Asp Pro Thr Ser Asp Glu
    4370                4375                4380                
Val His Gly Glu Gln Pro Ala Gly Pro Gly Gly Asp Ala Asp Gly Glu
4385                4390                4395                4400
Gly Ala Ser Glu Gly Ala Gly Asp Ala Ala Glu Gly Ala Gly Asp Glu
                4405                4410                4415    
Glu Glu Ala Val His Glu Ala Gly Pro Gly Gly Ala Asp Gly Ala Val
            4420                4425                4430        
Ala Val Thr Asp Gly Gly Pro Phe Arg Pro Glu Gly Ala Gly Gly Leu
        4435                4440                4445            
Gly Asp Met Gly Asp Thr Thr Pro Ala Glu Pro Pro Thr Pro Glu Gly
    4450                4455                4460                
Ser Pro Ile Leu Lys Arg Lys Leu Gly Val Asp Gly Val Glu Glu Glu
4465                4470                4475                4480
Leu Pro Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Leu Glu Pro Glu
                4485                4490                4495    
Lys Ala Asp Ala Glu Asn Gly Glu Lys Glu Glu Val Pro Glu Pro Thr
            4500                4505                4510        
Pro Glu Pro Pro Lys Lys Gln Ala Pro Pro Ser Pro Pro Pro Lys Lys
        4515                4520                4525            
Glu Glu Ala Gly Gly Glu Phe Trp Gly Glu Leu Glu Val Gln Arg Val
    4530                4535                4540                
Lys Phe Leu Asn Tyr Leu Ser Arg Asn Phe Tyr Thr Leu Arg Phe Leu
4545                4550                4555                4560
Ala Leu Phe Leu Ala Phe Ala Ile Asn Phe Ile Leu Leu Phe Tyr Lys
                4565                4570                4575    
Val Ser Asp Ser Pro Pro Gly Glu Asp Asp Met Glu Gly Ser Ala Ala
            4580                4585                4590        
Gly Asp Val Ser Gly Ala Gly Ser Gly Gly Ser Ser Gly Trp Gly Leu
        4595                4600                4605            
Gly Ala Gly Glu Glu Ala Glu Gly Asp Glu Asp Glu Asn Met Val Tyr
    4610                4615                4620                
Tyr Phe Leu Glu Glu Ser Thr Gly Tyr Met Glu Pro Ala Leu Arg Cys
4625                4630                4635                4640
Leu Ser Leu Leu His Thr Leu Val Ala Phe Leu Cys Ile Ile Gly Tyr
                4645                4650                4655    
Asn Cys Leu Lys Val Pro Leu Val Ile Phe Lys Arg Glu Lys Glu Leu
            4660                4665                4670        
Ala Arg Lys Leu Glu Phe Asp Gly Leu Tyr Ile Thr Glu Gln Pro Glu
        4675                4680                4685            
Asp Asp Asp Val Lys Gly Gln Trp Asp Arg Leu Val Leu Asn Thr Pro
    4690                4695                4700                
Ser Phe Pro Ser Asn Tyr Trp Asp Lys Phe Val Lys Arg Lys Val Leu
4705                4710                4715                4720
Asp Lys His Gly Asp Ile Tyr Gly Arg Glu Arg Ile Ala Glu Leu Leu
                4725                4730                4735    
Gly Met Asp Leu Ala Thr Leu Glu Ile Thr Ala His Asn Glu Arg Lys
            4740                4745                4750        
Pro Asn Pro Pro Pro Gly Leu Leu Thr Trp Leu Met Ser Ile Asp Val
        4755                4760                4765            
Lys Tyr Gln Ile Trp Lys Phe Gly Val Ile Phe Thr Asp Asn Ser Phe
    4770                4775                4780                
Leu Tyr Leu Gly Trp Tyr Met Val Met Ser Leu Leu Gly His Tyr Asn
4785                4790                4795                4800
Asn Phe Phe Phe Ala Ala His Leu Leu Asp Ile Ala Met Gly Val Lys
                4805                4810                4815    
Thr Leu Arg Thr Ile Leu Ser Ser Val Thr His Asn Gly Lys Gln Leu
            4820                4825                4830        
Val Met Thr Val Gly Leu Leu Ala Val Val Val Tyr Leu Tyr Thr Val
        4835                4840                4845            
Val Ala Phe Asn Phe Phe Arg Lys Phe Tyr Asn Lys Ser Glu Asp Glu
    4850                4855                4860                
Asp Glu Pro Asp Met Lys Cys Asp Asp Met Met Thr Cys Tyr Leu Phe
4865                4870                4875                4880
His Met Tyr Val Gly Val Arg Ala Gly Gly Gly Ile Gly Asp Glu Ile
                4885                4890                4895    
Glu Asp Pro Ala Gly Asp Glu Tyr Glu Leu Tyr Arg Val Val Phe Asp
            4900                4905                4910        
Ile Thr Phe Phe Phe Phe Val Ile Val Ile Leu Leu Ala Ile Ile Gln
        4915                4920                4925            
Gly Leu Ile Ile Asp Ala Phe Gly Glu Leu Arg Asp Gln Gln Glu Gln
    4930                4935                4940                
Val Lys Glu Asp Met Glu Thr Lys Cys Phe Ile Cys Gly Ile Gly Ser
4945                4950                4955                4960
Asp Tyr Phe Asp Thr Thr Pro His Gly Phe Glu Thr His Thr Leu Glu
                4965                4970                4975    
Glu His Asn Leu Ala Asn Tyr Met Phe Phe Leu Met Tyr Leu Ile Asn
            4980                4985                4990        
Lys Asp Glu Thr Glu His Thr Gly Gln Glu Ser Tyr Val Trp Lys Met
        4995                5000                5005            
Tyr Gln Glu Arg Cys Trp Asp Phe Phe Pro Ala Gly Asp Cys Phe Arg
    5010                5015                5020                
Lys Gln Tyr Glu Asp Gln Leu Ser
5025                5030        


<210> 27
<211> 536
<212> PRT
<213> Homo sapiens

<400> 27
Glu Phe Gly Arg Ala Ser Gln Ala Leu Thr Pro Pro Pro Gly Lys Ala
 1               5                  10                  15      
Ser Ala Gln Pro Leu Pro Ala Pro Glu Ala Ala His Thr Thr Gly Pro
            20                  25                  30          
Thr Gly Ser Ala Pro Asn Ser Pro Met Ala Leu Leu Thr Ile Gly Ser
        35                  40                  45              
Ser Ser Glu Lys Glu Ile Asp Asp Val Ile Asp Glu Ile Ile Ser Leu
    50                  55                  60                  
Glu Ser Ser Tyr Asn Asp Glu Met Leu Ser Tyr Leu Pro Gly Gly Thr
65                  70                  75                  80  
Thr Gly Leu Gln Leu Pro Ser Thr Leu Pro Val Ser Gly Asn Leu Leu
                85                  90                  95      
Asp Val Tyr Ser Ser Gln Gly Val Ala Thr Pro Ala Ile Thr Val Ser
            100                 105                 110         
Asn Ser Cys Pro Ala Glu Leu Pro Asn Ile Lys Arg Glu Ile Ser Glu
        115                 120                 125             
Thr Glu Ala Lys Ala Leu Leu Lys Glu Arg Gln Lys Lys Asp Asn His
    130                 135                 140                 
Asn Leu Ile Glu Arg Arg Arg Arg Phe Asn Ile Asn Asp Arg Ile Lys
145                 150                 155                 160 
Glu Leu Gly Thr Leu Ile Pro Lys Ser Ser Asp Pro Glu Met Arg Trp
                165                 170                 175     
Asn Lys Gly Thr Ile Leu Lys Ala Ser Val Asp Tyr Ile Arg Lys Leu
            180                 185                 190         
Gln Lys Glu Gln Gln Arg Ser Lys Asp Leu Glu Ser Arg Gln Arg Ser
        195                 200                 205             
Leu Glu Gln Ala Asn Arg Ser Leu Gln Leu Arg Ile Gln Glu Leu Glu
    210                 215                 220                 
Leu Gln Ala Gln Ile His Gly Leu Pro Val Pro Gly Thr Pro Gly Leu
225                 230                 235                 240 
Leu Ser Leu Ala Thr Thr Ser Thr Ser Asp Ser Leu Lys Pro Glu Gln
                245                 250                 255     
Leu Asp Ile Glu Glu Glu Gly Arg Pro Gly Ala Arg Thr Phe His Val
            260                 265                 270         
Gly Gly Gly Pro Ala Gln Asn Ala Pro His Gln Gln Pro Pro Ala Pro
        275                 280                 285             
Pro Ser Asp Ala Leu Leu Asp Leu His Phe Pro Ser Asp His Leu Gly
    290                 295                 300                 
Asp Leu Gly Asp Pro Phe His Leu Gly Leu Glu Asp Ile Leu Met Glu
305                 310                 315                 320 
Glu Glu Glu Gly Val Val Gly Gly Leu Ser Gly Gly Ala Leu Ser Pro
                325                 330                 335     
Leu Arg Ala Ala Ser Asp Pro Leu Leu Ser Ser Val Ser Leu Leu Ser
            340                 345                 350         
Pro Arg Pro Ala Ala Ala Ala Ala Ala Ser Ala Trp Lys Arg Ser Pro
        355                 360                 365             
Asp Gln Ala Ser Pro Leu Pro Trp Thr Phe Pro Pro Arg Lys Gly Gly
    370                 375                 380                 
Pro Cys Arg Met Arg Pro Arg Leu Phe Pro His Pro Pro Met Arg Leu
385                 390                 395                 400 
Pro Arg Tyr Leu Gly Arg Gly Asp Val Ile Arg Pro His Pro Cys Asn
                405                 410                 415     
Gln Ala Arg Arg Arg Ser Gln Met Arg Pro Cys Thr Phe Pro Lys Gly
            420                 425                 430         
Thr Ala Gln Cys Arg Tyr Phe Arg Arg Arg Arg Leu Glu Lys Asp Met
        435                 440                 445             
Arg Ser Gly Pro Ala Pro Trp Gly Ser Gln Pro His Pro Cys Pro Cys
    450                 455                 460                 
Gly Thr His Pro Cys Pro Gly Glu Gly Arg Arg Gln Asp Glu Val Ser
465                 470                 475                 480 
Thr Leu Ser Pro Arg Asp Cys Pro Ser Gln Val Ser Trp Glu Arg Glu
                485                 490                 495     
Met Ser Gly Cys Cys Ser Ile Leu Cys Leu Gly Thr Thr Ser Leu Val
            500                 505                 510         
Arg Pro Gly Thr Glu Glu Glu Ser Ser Asn Gly Gly Pro Ser Pro Gly
        515                 520                 525             
Gly Leu Ser Ser Ala Pro Ser Pro
    530                 535     


<210> 28
<211> 673
<212> PRT
<213> Homo sapiens

<400> 28
Met Ala Lys Pro Ala Gln Gly Ala Lys Tyr Arg Gly Ser Ile His Asp
 1               5                  10                  15      
Phe Pro Gly Phe Asp Pro Asn Gln Asp Ala Glu Ala Leu Tyr Thr Ala
            20                  25                  30          
Met Lys Gly Phe Gly Ser Asp Lys Glu Ala Ile Leu Asp Ile Ile Thr
        35                  40                  45              
Ser Arg Ser Asn Arg Gln Arg Gln Glu Val Cys Gln Ser Tyr Lys Ser
    50                  55                  60                  
Leu Tyr Gly Lys Asp Leu Ile Ala Asp Leu Lys Tyr Glu Leu Thr Gly
65                  70                  75                  80  
Lys Phe Glu Arg Leu Ile Val Gly Leu Met Arg Pro Pro Ala Tyr Cys
                85                  90                  95      
Asp Ala Lys Glu Ile Lys Asp Ala Ile Ser Gly Ile Gly Thr Asp Glu
            100                 105                 110         
Lys Cys Leu Ile Glu Ile Leu Ala Ser Arg Thr Asn Glu Gln Met His
        115                 120                 125             
Gln Leu Val Ala Ala Tyr Lys Asp Ala Tyr Glu Arg Asp Leu Glu Ala
    130                 135                 140                 
Asp Ile Ile Gly Asp Thr Ser Gly His Phe Gln Lys Met Leu Val Val
145                 150                 155                 160 
Leu Leu Gln Gly Thr Arg Glu Glu Asp Asp Val Val Ser Glu Asp Leu
                165                 170                 175     
Val Gln Gln Asp Val Gln Asp Leu Tyr Glu Ala Gly Glu Leu Lys Trp
            180                 185                 190         
Gly Thr Asp Glu Ala Gln Phe Ile Tyr Ile Leu Gly Asn Arg Ser Lys
        195                 200                 205             
Gln His Leu Arg Leu Val Phe Asp Glu Tyr Leu Lys Thr Thr Gly Lys
    210                 215                 220                 
Pro Ile Glu Ala Ser Ile Arg Gly Glu Leu Ser Gly Asp Phe Glu Lys
225                 230                 235                 240 
Leu Met Leu Ala Val Val Lys Cys Ile Arg Ser Thr Pro Glu Tyr Phe
                245                 250                 255     
Ala Glu Arg Leu Phe Lys Ala Met Lys Gly Leu Gly Thr Arg Asp Asn
            260                 265                 270         
Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Leu Asp Met Leu Asp
        275                 280                 285             
Ile Arg Glu Ile Phe Arg Thr Lys Tyr Glu Lys Ser Leu Tyr Ser Met
    290                 295                 300                 
Ile Lys Asn Asp Thr Ser Gly Glu Tyr Lys Lys Thr Leu Leu Lys Leu
305                 310                 315                 320 
Ser Gly Gly Asp Asp Asp Ala Ala Gly Gln Phe Phe Pro Glu Ala Ala
                325                 330                 335     
Gln Val Ala Tyr Gln Met Trp Glu Leu Ser Ala Val Ala Arg Val Glu
            340                 345                 350         
Leu Lys Gly Thr Val Arg Pro Ala Asn Asp Phe Asn Pro Asp Ala Asp
        355                 360                 365             
Ala Lys Ala Leu Arg Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Asp
    370                 375                 380                 
Thr Ile Ile Asp Ile Ile Thr His Arg Ser Asn Val Gln Arg Gln Gln
385                 390                 395                 400 
Ile Arg Gln Thr Phe Lys Ser His Phe Gly Arg Asp Leu Met Thr Asp
                405                 410                 415     
Leu Lys Ser Glu Ile Ser Gly Asp Leu Ala Arg Leu Ile Leu Gly Leu
            420                 425                 430         
Met Met Pro Pro Ala His Tyr Asp Ala Lys Gln Leu Lys Lys Ala Met
        435                 440                 445             
Glu Gly Ala Gly Thr Asp Glu Lys Ala Leu Ile Glu Ile Leu Ala Thr
    450                 455                 460                 
Arg Thr Asn Ala Glu Ile Arg Ala Ile Asn Glu Ala Tyr Lys Glu Asp
465                 470                 475                 480 
Tyr His Lys Ser Leu Glu Asp Ala Leu Ser Ser Asp Thr Ser Gly His
                485                 490                 495     
Phe Arg Arg Ile Leu Ile Ser Leu Ala Thr Gly His Arg Glu Glu Gly
            500                 505                 510         
Gly Glu Asn Leu Asp Gln Ala Arg Glu Asp Ala Gln Val Ala Ala Glu
        515                 520                 525             
Ile Leu Glu Ile Ala Asp Thr Pro Ser Gly Asp Lys Thr Ser Leu Glu
    530                 535                 540                 
Thr Arg Phe Met Thr Ile Leu Cys Thr Arg Ser Tyr Pro His Leu Arg
545                 550                 555                 560 
Arg Val Phe Gln Glu Phe Ile Lys Met Thr Asn Tyr Asp Val Glu His
                565                 570                 575     
Thr Ile Lys Lys Glu Met Ser Gly Asp Val Arg Asp Ala Phe Val Ala
            580                 585                 590         
Ile Val Gln Ser Val Lys Asn Lys Pro Leu Phe Phe Ala Asp Lys Leu
        595                 600                 605             
Tyr Lys Ser Met Lys Gly Ala Gly Thr Asp Glu Lys Thr Leu Thr Arg
    610                 615                 620                 
Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asn Ile Arg Arg Glu
625                 630                 635                 640 
Phe Ile Glu Lys Tyr Asp Lys Ser Leu His Gln Ala Ile Glu Gly Asp
                645                 650                 655     
Thr Ser Gly Asp Phe Leu Lys Ala Leu Leu Ala Leu Cys Gly Gly Glu
            660                 665                 670         
Asp
    


<210> 29
<211> 1042
<212> PRT
<213> Homo sapiens

<400> 29
Met Glu Asn Ala His Thr Lys Thr Val Glu Glu Val Leu Gly His Phe
 1               5                  10                  15      
Gly Val Asn Glu Ser Thr Gly Leu Ser Leu Glu Gln Val Lys Lys Leu
            20                  25                  30          
Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr
        35                  40                  45              
Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile
    50                  55                  60                  
Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu
65                  70                  75                  80  
Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu
                85                  90                  95      
Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala
            100                 105                 110         
Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys
        115                 120                 125             
Val Tyr Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp
    130                 135                 140                 
Ile Val Pro Gly Asp Ile Val Glu Ile Ala Val Gly Asp Lys Val Pro
145                 150                 155                 160 
Ala Asp Ile Arg Leu Thr Ser Ile Lys Ser Thr Thr Leu Arg Val Asp
                165                 170                 175     
Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Asp
            180                 185                 190         
Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu
        195                 200                 205             
Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Met Gly Val Val Val
    210                 215                 220                 
Ala Thr Gly Val Asn Thr Glu Ile Gly Lys Ile Arg Asp Glu Met Val
225                 230                 235                 240 
Ala Thr Glu Gln Glu Arg Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe
                245                 250                 255     
Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Ile Ala Val Trp
            260                 265                 270         
Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp
        275                 280                 285             
Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val
    290                 295                 300                 
Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala
305                 310                 315                 320 
Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu
                325                 330                 335     
Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys
            340                 345                 350         
Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Ile
        355                 360                 365             
Leu Asp Arg Val Glu Gly Asp Thr Cys Ser Leu Asn Glu Phe Thr Ile
    370                 375                 380                 
Thr Gly Ser Thr Tyr Ala Pro Ile Gly Glu Val His Lys Asp Asp Lys
385                 390                 395                 400 
Pro Val Asn Cys His Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile
                405                 410                 415     
Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly
            420                 425                 430         
Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu
        435                 440                 445             
Val Glu Lys Met Asn Val Phe Asp Thr Glu Leu Lys Gly Leu Ser Lys
    450                 455                 460                 
Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Lys Gln Leu Met Lys
465                 470                 475                 480 
Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val
                485                 490                 495     
Tyr Cys Thr Pro Asn Lys Pro Ser Arg Thr Ser Met Ser Lys Met Phe
            500                 505                 510         
Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Thr His Ile Arg
        515                 520                 525             
Val Gly Ser Thr Lys Val Pro Met Thr Ser Gly Val Lys Gln Lys Ile
    530                 535                 540                 
Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys
545                 550                 555                 560 
Leu Ala Leu Ala Thr His Asp Asn Pro Leu Arg Arg Glu Glu Met His
                565                 570                 575     
Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu Thr Asn Leu Thr Phe
            580                 585                 590         
Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Ile Glu Val Ala Ser
        595                 600                 605             
Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg Val Ile Met Ile Thr
    610                 615                 620                 
Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Ile Gly Ile
625                 630                 635                 640 
Phe Gly Gln Asp Glu Asp Val Thr Ser Lys Ala Phe Thr Gly Arg Glu
                645                 650                 655     
Phe Asp Glu Leu Asn Pro Ser Ala Gln Arg Asp Ala Cys Leu Asn Ala
            660                 665                 670         
Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu
        675                 680                 685             
Phe Leu Gln Ser Phe Asp Glu Ile Thr Ala Met Thr Gly Asp Gly Val
    690                 695                 700                 
Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met Gly
705                 710                 715                 720 
Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala Asp
                725                 730                 735     
Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile
            740                 745                 750         
Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val
        755                 760                 765             
Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Phe Pro Glu
    770                 775                 780                 
Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly
785                 790                 795                 800 
Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met
                805                 810                 815     
Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile Ser Gly Trp Leu
            820                 825                 830         
Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala Ala Thr Val
        835                 840                 845             
Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp Gly Gly Pro Arg Val
    850                 855                 860                 
Ser Phe Tyr Gln Leu Ser His Phe Leu Gln Cys Lys Glu Asp Asn Pro
865                 870                 875                 880 
Asp Phe Glu Gly Val Asp Cys Ala Ile Phe Glu Ser Pro Tyr Pro Met
                885                 890                 895     
Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu
            900                 905                 910         
Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Glu
        915                 920                 925             
Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser Leu His Phe
    930                 935                 940                 
Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe Gln Ile Thr Pro
945                 950                 955                 960 
Leu Asn Val Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro Val
                965                 970                 975     
Ile Leu Met Asp Glu Thr Leu Lys Phe Val Ala Arg Asn Tyr Leu Glu
            980                 985                 990         
Pro Gly Lys Glu Cys Val Gln Pro Ala Thr Lys Ser Cys Ser Phe Ser
        995                 1000                1005            
Ala Cys Thr Asp Gly Ile Ser Trp Pro Phe Val Leu Leu Ile Met Pro
    1010                1015                1020                
Leu Val Ile Trp Val Tyr Ser Thr Asp Thr Asn Phe Ser Asp Met Phe
1025                1030                1035                1040
Trp Ser
        


<210> 30
<211> 1023
<212> PRT
<213> Homo sapiens

<400> 30
Met Gly Lys Gly Val Gly Arg Asp Lys Tyr Glu Pro Ala Ala Val Ser
 1               5                  10                  15      
Glu Gln Gly Asp Lys Lys Gly Lys Lys Gly Lys Lys Asp Arg Asp Met
            20                  25                  30          
Asp Glu Leu Lys Lys Glu Val Ser Met Asp Asp His Lys Leu Ser Leu
        35                  40                  45              
Asp Glu Leu His Arg Lys Tyr Gly Thr Asp Leu Ser Arg Gly Leu Thr
    50                  55                  60                  
Ser Ala Arg Ala Ala Glu Ile Leu Ala Arg Asp Gly Pro Asn Ala Leu
65                  70                  75                  80  
Thr Pro Pro Pro Thr Thr Pro Glu Trp Ile Lys Phe Cys Arg Gln Leu
                85                  90                  95      
Phe Gly Gly Phe Ser Met Leu Leu Trp Ile Gly Ala Ile Leu Cys Phe
            100                 105                 110         
Leu Ala Tyr Ser Ile Gln Ala Ala Thr Glu Glu Glu Pro Gln Asn Asp
        115                 120                 125             
Asn Leu Tyr Leu Gly Val Val Leu Ser Ala Val Val Ile Ile Thr Gly
    130                 135                 140                 
Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser Ser Lys Ile Met Glu Ser
145                 150                 155                 160 
Phe Lys Asn Met Val Pro Gln Gln Ala Leu Val Ile Arg Asn Gly Glu
                165                 170                 175     
Lys Met Ser Ile Asn Ala Glu Glu Val Val Val Gly Asp Leu Val Glu
            180                 185                 190         
Val Lys Gly Gly Asp Arg Ile Pro Ala Asp Leu Arg Ile Ile Ser Ala
        195                 200                 205             
Asn Gly Cys Lys Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro
    210                 215                 220                 
Gln Thr Arg Ser Pro Asp Phe Thr Asn Glu Asn Pro Leu Glu Thr Arg
225                 230                 235                 240 
Asn Ile Ala Phe Phe Ser Thr Asn Cys Val Glu Gly Thr Ala Arg Gly
                245                 250                 255     
Ile Val Val Tyr Thr Gly Asp Arg Thr Val Met Gly Arg Ile Ala Thr
            260                 265                 270         
Leu Ala Ser Gly Leu Glu Gly Gly Gln Thr Pro Ile Ala Ala Glu Ile
        275                 280                 285             
Glu His Phe Ile His Ile Ile Thr Gly Val Ala Val Phe Leu Gly Val
    290                 295                 300                 
Ser Phe Phe Ile Leu Ser Leu Ile Leu Glu Tyr Thr Trp Leu Glu Ala
305                 310                 315                 320 
Val Ile Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly Leu
                325                 330                 335     
Leu Ala Thr Val Thr Val Cys Leu Thr Leu Thr Ala Lys Arg Met Ala
            340                 345                 350         
Arg Lys Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly
        355                 360                 365             
Ser Thr Ser Thr Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn
    370                 375                 380                 
Arg Met Thr Val Ala His Met Trp Phe Asp Asn Gln Ile His Glu Ala
385                 390                 395                 400 
Asp Thr Thr Glu Asn Gln Ser Gly Val Ser Phe Asp Lys Thr Ser Ala
                405                 410                 415     
Thr Trp Leu Ala Leu Ser Arg Ile Ala Gly Leu Cys Asn Arg Ala Val
            420                 425                 430         
Phe Gln Ala Asn Gln Glu Asn Leu Pro Ile Leu Lys Arg Ala Val Ala
        435                 440                 445             
Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys Cys Ile Glu Leu Cys Cys
    450                 455                 460                 
Gly Ser Val Lys Glu Met Arg Glu Arg Tyr Ala Lys Ile Val Glu Ile
465                 470                 475                 480 
Pro Phe Asn Ser Thr Asn Lys Tyr Gln Leu Ser Ile His Lys Asn Pro
                485                 490                 495     
Asn Thr Ser Glu Pro Gln His Leu Leu Val Met Lys Gly Ala Pro Glu
            500                 505                 510         
Arg Ile Leu Asp Arg Cys Ser Ser Ile Leu Leu His Gly Lys Glu Gln
        515                 520                 525             
Pro Leu Asp Glu Glu Leu Lys Asp Ala Phe Gln Asn Ala Tyr Leu Glu
    530                 535                 540                 
Leu Gly Gly Leu Gly Glu Arg Val Leu Gly Phe Cys His Leu Phe Leu
545                 550                 555                 560 
Pro Asp Glu Gln Phe Pro Glu Gly Phe Gln Phe Asp Thr Asp Asp Val
                565                 570                 575     
Asn Phe Pro Ile Asp Asn Leu Cys Phe Val Gly Leu Ile Ser Met Ile
            580                 585                 590         
Asp Pro Pro Arg Ala Ala Val Pro Asp Ala Val Gly Lys Cys Arg Ser
        595                 600                 605             
Ala Gly Ile Lys Val Ile Met Val Thr Gly Asp His Pro Ile Thr Ala
    610                 615                 620                 
Lys Ala Ile Ala Lys Gly Val Gly Ile Ile Ser Glu Gly Asn Glu Thr
625                 630                 635                 640 
Val Glu Asp Ile Ala Ala Arg Leu Asn Ile Pro Val Ser Gln Val Asn
                645                 650                 655     
Pro Arg Asp Ala Lys Ala Cys Val Val His Gly Ser Asp Leu Lys Asp
            660                 665                 670         
Met Thr Ser Glu Gln Leu Asp Asp Ile Leu Lys Tyr His Thr Glu Ile
        675                 680                 685             
Val Phe Ala Arg Thr Ser Pro Gln Gln Lys Leu Ile Ile Val Glu Gly
    690                 695                 700                 
Cys Gln Arg Gln Gly Ala Ile Val Ala Val Thr Gly Asp Gly Val Asn
705                 710                 715                 720 
Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile Gly Val Ala Met Gly Ile
                725                 730                 735     
Ala Gly Ser Asp Val Ser Lys Gln Ala Ala Asp Met Ile Leu Leu Asp
            740                 745                 750         
Asp Asn Phe Ala Ser Ile Val Thr Gly Val Glu Glu Gly Arg Leu Ile
        755                 760                 765             
Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr Thr Leu Thr Ser Asn Ile
    770                 775                 780                 
Pro Glu Ile Thr Pro Phe Leu Ile Phe Ile Ile Ala Asn Ile Pro Leu
785                 790                 795                 800 
Pro Leu Gly Thr Val Thr Ile Leu Cys Ile Asp Leu Gly Thr Asp Met
                805                 810                 815     
Val Pro Ala Ile Ser Leu Ala Tyr Glu Gln Ala Glu Ser Asp Ile Met
            820                 825                 830         
Lys Arg Gln Pro Arg Asn Pro Lys Thr Asp Lys Leu Val Asn Glu Arg
        835                 840                 845             
Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly Met Ile Gln Ala Leu Gly
    850                 855                 860                 
Gly Phe Phe Thr Tyr Phe Val Ile Leu Ala Glu Asn Gly Phe Leu Pro
865                 870                 875                 880 
Ile His Leu Leu Gly Leu Arg Val Asp Trp Asp Asp Arg Trp Ile Asn
                885                 890                 895     
Asp Val Glu Asp Ser Tyr Gly Gln Gln Trp Thr Tyr Glu Gln Arg Lys
            900                 905                 910         
Ile Val Glu Phe Thr Cys His Thr Ala Phe Phe Val Ser Ile Val Val
        915                 920                 925             
Val Gln Trp Ala Asp Leu Val Ile Cys Lys Thr Arg Arg Asn Ser Val
    930                 935                 940                 
Phe Gln Gln Gly Met Lys Asn Lys Ile Leu Ile Phe Gly Leu Phe Glu
945                 950                 955                 960 
Glu Thr Ala Leu Ala Ala Phe Leu Ser Tyr Cys Pro Gly Met Gly Val
                965                 970                 975     
Ala Leu Arg Met Tyr Pro Leu Lys Pro Thr Trp Trp Phe Cys Ala Phe
            980                 985                 990         
Pro Tyr Ser Leu Leu Ile Phe Val Tyr Asp Glu Val Arg Lys Leu Ile
        995                 1000                1005            
Ile Arg Arg Arg Pro Gly Gly Trp Val Glu Lys Glu Thr Tyr Tyr
    1010                1015                1020            


<210> 31
<211> 1023
<212> PRT
<213> Homo sapiens

<400> 31
Met Gly Lys Gly Val Gly Arg Asp Lys Tyr Glu Pro Ala Ala Val Ser
 1               5                  10                  15      
Glu Gln Gly Asp Lys Lys Gly Lys Lys Gly Lys Lys Asp Arg Asp Met
            20                  25                  30          
Asp Glu Leu Lys Lys Glu Val Ser Met Asp Asp His Lys Leu Ser Leu
        35                  40                  45              
Asp Glu Leu His Arg Lys Tyr Gly Thr Asp Leu Ser Arg Gly Leu Thr
    50                  55                  60                  
Ser Ala Arg Ala Ala Glu Ile Leu Ala Arg Asp Gly Pro Asn Ala Leu
65                  70                  75                  80  
Thr Pro Pro Pro Thr Thr Pro Glu Trp Ile Lys Phe Cys Arg Gln Leu
                85                  90                  95      
Phe Gly Gly Phe Ser Met Leu Leu Trp Ile Gly Ala Ile Leu Cys Phe
            100                 105                 110         
Leu Ala Tyr Ser Ile Gln Ala Ala Thr Glu Glu Glu Pro Gln Asn Asp
        115                 120                 125             
Asn Leu Tyr Leu Gly Val Val Leu Ser Ala Val Val Ile Ile Thr Gly
    130                 135                 140                 
Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser Ser Lys Ile Met Glu Ser
145                 150                 155                 160 
Phe Lys Asn Met Val Pro Gln Gln Ala Leu Val Ile Arg Asn Gly Glu
                165                 170                 175     
Lys Met Ser Ile Asn Ala Glu Glu Val Val Val Gly Asp Leu Val Glu
            180                 185                 190         
Val Lys Gly Gly Asp Arg Ile Pro Ala Asp Leu Arg Ile Ile Ser Ala
        195                 200                 205             
Asn Gly Cys Lys Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro
    210                 215                 220                 
Gln Thr Arg Ser Pro Asp Phe Thr Asn Glu Asn Pro Leu Glu Thr Arg
225                 230                 235                 240 
Asn Ile Ala Phe Phe Ser Thr Asn Cys Val Glu Gly Thr Ala Arg Gly
                245                 250                 255     
Ile Val Val Tyr Thr Gly Asp Arg Thr Val Met Gly Arg Ile Ala Thr
            260                 265                 270         
Leu Ala Ser Gly Leu Glu Gly Gly Gln Thr Pro Ile Ala Ala Glu Ile
        275                 280                 285             
Glu His Phe Ile His Ile Ile Thr Gly Val Ala Val Phe Leu Gly Val
    290                 295                 300                 
Ser Phe Phe Ile Leu Ser Leu Ile Leu Glu Tyr Thr Trp Leu Glu Ala
305                 310                 315                 320 
Val Ile Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly Leu
                325                 330                 335     
Leu Ala Thr Val Thr Val Cys Leu Thr Leu Thr Ala Lys Arg Met Ala
            340                 345                 350         
Arg Lys Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly
        355                 360                 365             
Ser Thr Ser Thr Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn
    370                 375                 380                 
Arg Met Thr Val Ala His Met Trp Phe Asp Asn Gln Ile His Glu Ala
385                 390                 395                 400 
Asp Thr Thr Glu Asn Gln Ser Gly Val Ser Phe Asp Lys Thr Ser Ala
                405                 410                 415     
Thr Trp Leu Ala Leu Ser Arg Ile Ala Gly Leu Cys Asn Arg Ala Val
            420                 425                 430         
Phe Gln Ala Asn Gln Glu Asn Leu Pro Ile Leu Lys Arg Ala Val Ala
        435                 440                 445             
Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys Cys Ile Glu Leu Cys Cys
    450                 455                 460                 
Gly Ser Val Lys Glu Met Arg Glu Arg Tyr Ala Lys Ile Val Glu Ile
465                 470                 475                 480 
Pro Phe Asn Ser Thr Asn Lys Tyr Gln Leu Ser Ile His Lys Asn Pro
                485                 490                 495     
Asn Thr Ser Glu Pro Gln His Leu Leu Val Met Lys Gly Ala Pro Glu
            500                 505                 510         
Arg Ile Leu Asp Arg Cys Ser Ser Ile Leu Leu His Gly Lys Glu Gln
        515                 520                 525             
Pro Leu Asp Glu Glu Leu Lys Asp Ala Phe Gln Asn Ala Tyr Leu Glu
    530                 535                 540                 
Leu Gly Gly Leu Gly Glu Arg Val Leu Gly Phe Cys His Leu Phe Leu
545                 550                 555                 560 
Pro Asp Glu Gln Phe Pro Glu Gly Phe Gln Phe Asp Thr Asp Asp Val
                565                 570                 575     
Asn Phe Pro Ile Asp Asn Leu Cys Phe Val Gly Leu Ile Ser Met Ile
            580                 585                 590         
Asp Pro Pro Arg Ala Ala Val Pro Asp Ala Val Gly Lys Cys Arg Ser
        595                 600                 605             
Ala Gly Ile Lys Val Ile Met Val Thr Gly Asp His Pro Ile Thr Ala
    610                 615                 620                 
Lys Ala Ile Ala Lys Gly Val Gly Ile Ile Ser Glu Gly Asn Glu Thr
625                 630                 635                 640 
Val Glu Asp Ile Ala Ala Arg Leu Asn Ile Pro Val Ser Gln Val Asn
                645                 650                 655     
Pro Arg Asp Ala Lys Ala Cys Val Val His Gly Ser Asp Leu Lys Asp
            660                 665                 670         
Met Thr Ser Glu Gln Leu Asp Asp Ile Leu Lys Tyr His Thr Glu Ile
        675                 680                 685             
Val Phe Ala Arg Thr Ser Pro Gln Gln Lys Leu Ile Ile Val Glu Gly
    690                 695                 700                 
Cys Gln Arg Gln Gly Ala Ile Val Ala Val Thr Gly Asp Gly Val Asn
705                 710                 715                 720 
Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile Gly Val Ala Met Gly Ile
                725                 730                 735     
Ala Gly Ser Asp Val Ser Lys Gln Ala Ala Asp Met Ile Leu Leu Asp
            740                 745                 750         
Asp Asn Phe Ala Ser Ile Val Thr Gly Val Glu Glu Gly Arg Leu Ile
        755                 760                 765             
Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr Thr Leu Thr Ser Asn Ile
    770                 775                 780                 
Pro Glu Ile Thr Pro Phe Leu Ile Phe Ile Ile Ala Asn Ile Pro Leu
785                 790                 795                 800 
Pro Leu Gly Thr Val Thr Ile Leu Cys Ile Asp Leu Gly Thr Asp Met
                805                 810                 815     
Val Pro Ala Ile Ser Leu Ala Tyr Glu Gln Ala Glu Ser Asp Ile Met
            820                 825                 830         
Lys Arg Gln Pro Arg Asn Pro Lys Thr Asp Lys Leu Val Asn Glu Arg
        835                 840                 845             
Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly Met Ile Gln Ala Leu Gly
    850                 855                 860                 
Gly Phe Phe Thr Tyr Phe Val Ile Leu Ala Glu Asn Gly Phe Leu Pro
865                 870                 875                 880 
Ile His Leu Leu Gly Leu Arg Val Asp Trp Asp Asp Arg Trp Ile Asn
                885                 890                 895     
Asp Val Glu Asp Ser Tyr Gly Gln Gln Trp Thr Tyr Glu Gln Arg Lys
            900                 905                 910         
Ile Val Glu Phe Thr Cys His Thr Ala Phe Phe Val Ser Ile Val Val
        915                 920                 925             
Val Gln Trp Ala Asp Leu Val Ile Cys Lys Thr Arg Arg Asn Ser Val
    930                 935                 940                 
Phe Gln Gln Gly Met Lys Asn Lys Ile Leu Ile Phe Gly Leu Phe Glu
945                 950                 955                 960 
Glu Thr Ala Leu Ala Ala Phe Leu Ser Tyr Cys Pro Gly Met Gly Val
                965                 970                 975     
Ala Leu Arg Met Tyr Pro Leu Lys Pro Thr Trp Trp Phe Cys Ala Phe
            980                 985                 990         
Pro Tyr Ser Leu Leu Ile Phe Val Tyr Asp Glu Val Arg Lys Leu Ile
        995                 1000                1005            
Ile Arg Arg Arg Pro Gly Gly Trp Val Glu Lys Glu Thr Tyr Tyr
    1010                1015                1020            


<210> 32
<211> 529
<212> PRT
<213> Homo sapiens

<400> 32
Met Leu Gly Phe Val Gly Arg Val Ala Ala Ala Pro Ala Ser Gly Ala
 1               5                  10                  15      
Leu Arg Arg Leu Thr Pro Ser Ala Ser Leu Pro Pro Ala Gln Leu Leu
            20                  25                  30          
Leu Arg Ala Ala Pro Thr Ala Val His Pro Val Arg Asp Tyr Ala Ala
        35                  40                  45              
Gln Thr Ser Pro Ser Pro Lys Ala Gly Ala Ala Thr Gly Arg Ile Val
    50                  55                  60                  
Ala Val Ile Gly Ala Val Val Asp Val Gln Phe Asp Glu Gly Leu Pro
65                  70                  75                  80  
Pro Ile Leu Asn Ala Leu Glu Val Gln Gly Arg Glu Thr Arg Leu Val
                85                  90                  95      
Leu Glu Val Ala Gln His Leu Gly Glu Ser Thr Val Arg Thr Ile Ala
            100                 105                 110         
Met Asp Gly Thr Glu Gly Leu Val Arg Gly Gln Lys Val Leu Asp Ser
        115                 120                 125             
Gly Ala Pro Ile Lys Ile Pro Val Gly Pro Glu Thr Leu Gly Arg Ile
    130                 135                 140                 
Met Asn Val Ile Gly Glu Pro Ile Asp Glu Arg Gly Pro Ile Lys Thr
145                 150                 155                 160 
Lys Gln Phe Ala Pro Ile His Ala Glu Ala Pro Glu Phe Met Glu Met
                165                 170                 175     
Ser Val Glu Gln Glu Ile Leu Val Thr Gly Ile Lys Val Val Asp Leu
            180                 185                 190         
Leu Ala Pro Tyr Ala Lys Gly Gly Lys Ile Gly Leu Phe Gly Gly Ala
        195                 200                 205             
Gly Val Gly Lys Thr Val Leu Ile Met Glu Leu Ile Asn Asn Val Ala
    210                 215                 220                 
Lys Ala His Gly Gly Tyr Ser Val Phe Ala Gly Val Gly Glu Arg Thr
225                 230                 235                 240 
Arg Glu Gly Asn Asp Leu Tyr His Glu Met Ile Glu Ser Gly Val Ile
                245                 250                 255     
Asn Leu Lys Asp Ala Thr Ser Lys Val Ala Leu Val Tyr Gly Gln Met
            260                 265                 270         
Asn Glu Pro Pro Gly Ala Arg Ala Arg Val Ala Leu Thr Gly Leu Thr
        275                 280                 285             
Val Ala Glu Tyr Phe Arg Asp Gln Glu Gly Gln Asp Val Leu Leu Phe
    290                 295                 300                 
Ile Asp Asn Ile Phe Arg Phe Thr Gln Ala Gly Ser Glu Val Ser Ala
305                 310                 315                 320 
Leu Leu Gly Arg Ile Pro Ser Ala Val Gly Tyr Gln Pro Thr Leu Ala
                325                 330                 335     
Thr Asp Met Gly Thr Met Gln Glu Arg Ile Thr Thr Thr Lys Lys Gly
            340                 345                 350         
Ser Ile Thr Ser Val Gln Ala Ile Tyr Val Pro Ala Asp Asp Leu Thr
        355                 360                 365             
Asp Pro Ala Pro Ala Thr Thr Phe Ala His Leu Asp Ala Thr Thr Val
    370                 375                 380                 
Leu Ser Arg Ala Ile Ala Glu Leu Gly Ile Tyr Pro Ala Val Asp Pro
385                 390                 395                 400 
Leu Asp Ser Thr Ser Arg Ile Met Asp Pro Asn Ile Val Gly Ser Glu
                405                 410                 415     
His Tyr Asp Val Ala Arg Gly Val Gln Lys Ile Leu Gln Asp Tyr Lys
            420                 425                 430         
Ser Leu Gln Asp Ile Ile Ala Ile Leu Gly Met Asp Glu Leu Ser Glu
        435                 440                 445             
Glu Asp Lys Leu Thr Val Ser Arg Ala Arg Lys Ile Gln Arg Phe Leu
    450                 455                 460                 
Ser Gln Pro Phe Gln Val Ala Glu Val Phe Thr Gly His Met Gly Lys
465                 470                 475                 480 
Leu Val Pro Leu Lys Glu Thr Ile Lys Gly Phe Gln Gln Ile Leu Ala
                485                 490                 495     
Gly Glu Tyr Asp His Leu Pro Glu Gln Ala Phe Tyr Met Val Gly Pro
            500                 505                 510         
Ile Glu Glu Ala Val Ala Lys Ala Asp Lys Leu Ala Glu Glu His Ser
        515                 520                 525             
Ser
    


<210> 33
<211> 935
<212> PRT
<213> Homo sapiens

<400> 33
Met Ala Pro Ala Glu Ile Leu Asn Gly Lys Glu Ile Ser Ala Gln Ile
 1               5                  10                  15      
Arg Ala Arg Leu Lys Asn Gln Val Thr Gln Leu Lys Glu Gln Val Pro
            20                  25                  30          
Gly Phe Thr Pro Arg Leu Ala Ile Leu Gln Val Gly Asn Arg Asp Asp
        35                  40                  45              
Ser Asn Leu Tyr Ile Asn Val Lys Leu Lys Ala Ala Glu Glu Ile Gly
    50                  55                  60                  
Ile Lys Ala Thr His Ile Lys Leu Pro Arg Thr Thr Thr Glu Ser Glu
65                  70                  75                  80  
Val Met Lys Tyr Ile Thr Ser Leu Asn Glu Asp Ser Thr Val His Gly
                85                  90                  95      
Phe Leu Val Gln Leu Pro Leu Asp Ser Glu Asn Ser Ile Asn Thr Glu
            100                 105                 110         
Glu Val Ile Asn Ala Ile Ala Pro Glu Lys Asp Val Asp Gly Leu Thr
        115                 120                 125             
Ser Ile Asn Ala Gly Arg Leu Ala Arg Gly Asp Leu Asn Asp Cys Phe
    130                 135                 140                 
Ile Pro Cys Thr Pro Lys Gly Cys Leu Glu Leu Ile Lys Glu Thr Gly
145                 150                 155                 160 
Val Pro Ile Ala Gly Arg His Ala Val Val Val Gly Arg Ser Lys Ile
                165                 170                 175     
Val Gly Ala Pro Met His Asp Leu Leu Leu Trp Asn Asn Ala Thr Val
            180                 185                 190         
Thr Thr Cys His Ser Lys Thr Ala His Leu Asp Glu Glu Val Asn Lys
        195                 200                 205             
Gly Asp Ile Leu Val Val Ala Thr Gly Gln Pro Glu Met Val Lys Gly
    210                 215                 220                 
Glu Trp Ile Lys Pro Gly Ala Ile Val Ile Asp Cys Gly Ile Asn Tyr
225                 230                 235                 240 
Val Pro Asp Asp Lys Lys Pro Asn Gly Arg Lys Val Val Gly Asp Val
                245                 250                 255     
Ala Tyr Asp Glu Ala Lys Glu Arg Ala Ser Phe Ile Thr Pro Val Pro
            260                 265                 270         
Gly Gly Val Gly Pro Met Thr Val Ala Met Leu Met Gln Ser Thr Val
        275                 280                 285             
Glu Ser Ala Lys Arg Phe Leu Glu Lys Phe Lys Pro Gly Lys Trp Met
    290                 295                 300                 
Ile Gln Tyr Asn Asn Leu Asn Leu Lys Thr Pro Val Pro Ser Asp Ile
305                 310                 315                 320 
Asp Ile Ser Arg Ser Cys Lys Pro Lys Pro Ile Gly Lys Leu Ala Arg
                325                 330                 335     
Glu Ile Gly Leu Leu Ser Glu Glu Val Glu Leu Tyr Gly Glu Thr Lys
            340                 345                 350         
Ala Lys Val Leu Leu Ser Ala Leu Glu Arg Leu Lys His Arg Pro Asp
        355                 360                 365             
Gly Lys Tyr Val Val Val Thr Gly Ile Thr Pro Thr Pro Leu Gly Glu
    370                 375                 380                 
Gly Lys Ser Thr Thr Thr Ile Gly Leu Val Gln Ala Leu Gly Ala His
385                 390                 395                 400 
Leu Tyr Gln Asn Val Phe Ala Cys Val Arg Gln Pro Ser Gln Gly Pro
                405                 410                 415     
Thr Phe Gly Ile Lys Gly Gly Ala Ala Gly Gly Gly Tyr Ser Gln Val
            420                 425                 430         
Ile Pro Met Glu Glu Phe Asn Leu His Leu Thr Gly Asp Ile His Ala
        435                 440                 445             
Ile Thr Ala Ala Asn Asn Leu Val Ala Ala Ala Ile Asp Ala Arg Ile
    450                 455                 460                 
Phe His Glu Leu Thr Gln Thr Asp Lys Ala Leu Phe Asn Arg Leu Val
465                 470                 475                 480 
Pro Ser Val Asn Gly Val Arg Arg Phe Ser Asp Ile Gln Ile Arg Arg
                485                 490                 495     
Leu Lys Arg Leu Gly Ile Glu Lys Thr Asp Pro Thr Thr Leu Thr Asp
            500                 505                 510         
Glu Glu Ile Asn Arg Phe Ala Arg Leu Asp Ile Asp Pro Glu Thr Ile
        515                 520                 525             
Thr Trp Gln Arg Val Leu Asp Thr Asn Asp Arg Phe Leu Arg Lys Ile
    530                 535                 540                 
Thr Ile Gly Gln Ala Pro Thr Glu Lys Gly His Thr Arg Thr Ala Gln
545                 550                 555                 560 
Phe Asp Ile Ser Val Ala Ser Glu Ile Met Ala Val Leu Ala Leu Thr
                565                 570                 575     
Thr Ser Leu Glu Asp Met Arg Glu Arg Leu Gly Lys Met Val Val Ala
            580                 585                 590         
Ser Ser Lys Lys Gly Glu Pro Val Ser Ala Glu Asp Leu Gly Val Ser
        595                 600                 605             
Gly Ala Leu Thr Val Leu Met Lys Asp Ala Ile Lys Pro Asn Leu Met
    610                 615                 620                 
Gln Thr Leu Glu Gly Thr Pro Val Phe Val His Ala Gly Pro Phe Ala
625                 630                 635                 640 
Asn Ile Ala His Gly Asn Ser Ser Ile Ile Ala Asp Arg Ile Ala Leu
                645                 650                 655     
Lys Leu Val Gly Pro Glu Gly Phe Val Val Thr Glu Ala Gly Phe Gly
            660                 665                 670         
Ala Asp Ile Gly Met Glu Lys Phe Phe Asn Ile Lys Cys Arg Tyr Ser
        675                 680                 685             
Gly Leu Cys Pro His Val Val Val Leu Val Ala Thr Val Arg Ala Leu
    690                 695                 700                 
Lys Met His Gly Gly Gly Pro Thr Val Thr Ala Gly Leu Pro Leu Pro
705                 710                 715                 720 
Lys Ala Tyr Ile Gln Glu Asn Leu Glu Leu Val Glu Lys Gly Phe Ser
                725                 730                 735     
Asn Leu Lys Lys Gln Ile Glu Asn Ala Arg Met Phe Gly Ile Pro Val
            740                 745                 750         
Val Val Ala Val Asn Ala Phe Lys Thr Asp Thr Glu Ser Glu Leu Asp
        755                 760                 765             
Leu Ile Ser Arg Leu Ser Arg Glu His Gly Ala Phe Asp Ala Val Lys
    770                 775                 780                 
Cys Thr His Trp Ala Glu Gly Gly Lys Gly Ala Leu Ala Leu Ala Gln
785                 790                 795                 800 
Ala Val Gln Arg Ala Ala Gln Ala Pro Ser Ser Phe Gln Leu Leu Tyr
                805                 810                 815     
Asp Leu Lys Leu Pro Val Glu Asp Lys Ile Arg Ile Ile Ala Gln Lys
            820                 825                 830         
Ile Tyr Gly Ala Asp Asp Ile Glu Leu Leu Pro Glu Ala Gln His Lys
        835                 840                 845             
Ala Glu Val Tyr Thr Lys Gln Gly Phe Gly Asn Leu Pro Ile Cys Met
    850                 855                 860                 
Ala Lys Thr His Leu Ser Leu Ser His Asn Pro Glu Gln Lys Gly Val
865                 870                 875                 880 
Pro Thr Gly Phe Ile Leu Pro Ile Arg Asp Ile Arg Ala Ser Val Gly
                885                 890                 895     
Ala Gly Phe Leu Tyr Pro Leu Val Gly Thr Met Ser Thr Met Pro Gly
            900                 905                 910         
Leu Pro Thr Arg Pro Cys Phe Tyr Asp Ile Asp Leu Asp Pro Glu Thr
        915                 920                 925             
Glu Gln Val Asn Gly Leu Phe
    930                 935 


<210> 34
<211> 129
<212> PRT
<213> Homo sapiens

<400> 34
Met Ala Ser Arg Leu Leu Arg Gly Ala Gly Thr Leu Ala Ala Gln Ala
 1               5                  10                  15      
Leu Arg Ala Arg Gly Pro Ser Gly Ala Ala Ala Met Arg Ser Met Ala
            20                  25                  30          
Ser Gly Gly Gly Val Pro Thr Asp Glu Glu Gln Ala Thr Gly Leu Glu
        35                  40                  45              
Arg Glu Ile Met Leu Ala Ala Lys Lys Gly Leu Asp Pro Tyr Asn Val
    50                  55                  60                  
Leu Ala Pro Lys Gly Ala Ser Gly Thr Arg Glu Asp Pro Asn Leu Val
65                  70                  75                  80  
Pro Ser Ile Ser Asn Lys Arg Ile Val Gly Cys Ile Cys Glu Glu Asp
                85                  90                  95      
Asn Thr Ser Val Val Trp Phe Trp Leu His Lys Gly Gln Ala Gln Arg
            100                 105                 110         
Cys Pro Arg Cys Gly Ala His Tyr Lys Leu Val Pro Gln Gln Leu Ala
        115                 120                 125             
His
    


<210> 35
<211> 325
<212> PRT
<213> Homo sapiens

<400> 35
Met Ala Ala Ala Ala Ala Ser Leu Arg Gly Val Val Leu Gly Pro Arg
 1               5                  10                  15      
Gly Ala Gly Leu Pro Gly Ala Arg Ala Arg Gly Leu Leu Cys Ser Ala
            20                  25                  30          
Arg Pro Gly Gln Leu Pro Leu Arg Thr Pro Gln Ala Val Ala Leu Ser
        35                  40                  45              
Ser Lys Ser Gly Leu Ser Arg Gly Arg Lys Val Met Leu Ser Ala Leu
    50                  55                  60                  
Gly Met Leu Ala Ala Gly Gly Ala Gly Leu Ala Val Ala Leu His Ser
65                  70                  75                  80  
Ala Val Ser Ala Ser Asp Leu Glu Leu His Pro Pro Ser Tyr Pro Trp
                85                  90                  95      
Ser His Arg Gly Leu Leu Ser Ser Leu Asp His Thr Ser Ile Arg Arg
            100                 105                 110         
Gly Phe Gln Val Tyr Lys Gln Val Cys Ala Ser Cys His Ser Met Asp
        115                 120                 125             
Phe Val Ala Tyr Arg His Leu Val Gly Val Cys Tyr Thr Glu Asp Glu
    130                 135                 140                 
Ala Lys Glu Leu Ala Ala Glu Val Glu Val Gln Asp Gly Pro Asn Glu
145                 150                 155                 160 
Asp Gly Glu Met Phe Met Arg Pro Gly Lys Leu Phe Asp Tyr Phe Pro
                165                 170                 175     
Lys Pro Tyr Pro Asn Ser Glu Ala Ala Arg Ala Ala Asn Asn Gly Ala
            180                 185                 190         
Leu Pro Pro Asp Leu Ser Tyr Ile Val Arg Ala Arg His Gly Gly Glu
        195                 200                 205             
Asp Tyr Val Phe Ser Leu Leu Thr Gly Tyr Cys Glu Pro Pro Thr Gly
    210                 215                 220                 
Val Ser Leu Arg Glu Gly Leu Tyr Phe Asn Pro Tyr Phe Pro Gly Gln
225                 230                 235                 240 
Ala Ile Ala Met Ala Pro Pro Ile Tyr Thr Asp Val Leu Glu Phe Asp
                245                 250                 255     
Asp Gly Thr Pro Ala Thr Met Ser Gln Ile Ala Lys Asp Val Cys Thr
            260                 265                 270         
Phe Leu Arg Trp Ala Ser Glu Pro Glu His Asp His Arg Lys Arg Met
        275                 280                 285             
Gly Leu Lys Met Leu Met Met Met Ala Leu Leu Val Pro Leu Val Tyr
    290                 295                 300                 
Thr Ile Lys Arg His Lys Trp Ser Val Leu Lys Ser Arg Lys Leu Ala
305                 310                 315                 320 
Tyr Arg Pro Pro Lys
                325 


<210> 36
<211> 380
<212> PRT
<213> Homo sapiens

<400> 36
Met Thr Pro Met Arg Lys Ile Asn Pro Leu Met Lys Leu Ile Asn His
 1               5                  10                  15      
Ser Phe Ile Asp Leu Pro Thr Pro Ser Asn Ile Ser Ala Trp Trp Asn
            20                  25                  30          
Phe Gly Ser Leu Leu Gly Ala Cys Leu Ile Leu Gln Ile Thr Thr Gly
        35                  40                  45              
Leu Phe Leu Ala Met His Tyr Ser Pro Asp Ala Ser Thr Ala Phe Ser
    50                  55                  60                  
Ser Ile Ala His Ile Thr Arg Asp Val Asn Tyr Gly Trp Ile Ile Arg
65                  70                  75                  80  
Tyr Leu His Ala Asn Gly Ala Ser Met Phe Phe Ile Cys Leu Phe Leu
                85                  90                  95      
His Ile Gly Arg Gly Leu Tyr Tyr Gly Ser Phe Leu Tyr Ser Glu Thr
            100                 105                 110         
Trp Asn Ile Gly Ile Ile Leu Leu Leu Ala Thr Met Ala Thr Ala Phe
        115                 120                 125             
Met Gly Tyr Val Leu Pro Trp Gly Gln Met Ser Phe Trp Gly Ala Thr
    130                 135                 140                 
Val Ile Thr Asn Leu Leu Ser Ala Ile Pro Tyr Ile Gly Thr Asp Leu
145                 150                 155                 160 
Val Gln Trp Ile Trp Gly Gly Tyr Ser Val Asp Ser Pro Thr Leu Thr
                165                 170                 175     
Arg Phe Phe Thr Phe His Phe Ile Leu Pro Phe Ile Ile Ala Ala Leu
            180                 185                 190         
Ala Thr Leu His Leu Leu Phe Leu His Glu Thr Gly Ser Asn Asn Pro
        195                 200                 205             
Leu Gly Ile Thr Ser His Ser Asp Lys Ile Thr Phe His Pro Tyr Tyr
    210                 215                 220                 
Thr Ile Lys Asp Ala Leu Gly Leu Leu Leu Phe Leu Leu Ser Leu Met
225                 230                 235                 240 
Thr Leu Thr Leu Phe Ser Pro Asp Leu Leu Gly Asp Pro Asp Asn Tyr
                245                 250                 255     
Thr Leu Ala Asn Pro Leu Asn Thr Pro Pro His Ile Lys Pro Glu Trp
            260                 265                 270         
Tyr Phe Leu Phe Ala Tyr Thr Ile Leu Arg Ser Val Pro Asn Lys Leu
        275                 280                 285             
Gly Gly Val Leu Ala Leu Leu Leu Ser Ile Leu Ile Leu Ala Met Ile
    290                 295                 300                 
Pro Ile Leu His Met Ser Lys Gln Gln Ser Met Met Phe Arg Pro Leu
305                 310                 315                 320 
Ser Gln Ser Leu Tyr Trp Leu Leu Ala Ala Asp Leu Leu Ile Leu Thr
                325                 330                 335     
Trp Ile Gly Gly Gln Pro Val Ser Tyr Pro Phe Thr Ile Ile Gly Gln
            340                 345                 350         
Val Ala Ser Val Leu Tyr Phe Thr Thr Ile Leu Ile Leu Met Pro Thr
        355                 360                 365             
Ile Ser Leu Ile Glu Asn Lys Met Leu Lys Trp Ala
    370                 375                 380 


<210> 37
<211> 334
<212> PRT
<213> Homo sapiens

<400> 37
Gly Lys Val Lys Val Gly Val Asp Gly Phe Gly Arg Ile Gly Arg Leu
 1               5                  10                  15      
Val Thr Arg Ala Ala Phe Asn Ser Gly Lys Val Asp Ile Val Ala Ile
            20                  25                  30          
Asn Asp Pro Phe Ile Asp Leu His Tyr Met Val Tyr Met Phe Gln Tyr
        35                  40                  45              
Asp Ser Thr His Gly Lys Phe His Gly Thr Val Lys Ala Glu Asp Gly
    50                  55                  60                  
Lys Leu Val Ile Asp Gly Lys Ala Ile Thr Ile Phe Gln Glu Arg Asp
65                  70                  75                  80  
Pro Glu Asn Ile Lys Trp Gly Asp Ala Gly Thr Ala Tyr Val Val Glu
                85                  90                  95      
Ser Thr Gly Val Phe Thr Thr Met Glu Lys Ala Gly Ala His Leu Lys
            100                 105                 110         
Gly Gly Ala Lys Arg Ile Val Ile Ser Ala Pro Ser Ala Asp Ala Pro
        115                 120                 125             
Met Phe Val Met Gly Val Asn His Phe Lys Tyr Ala Asn Ser Leu Lys
    130                 135                 140                 
Ile Ile Ser Asn Ala Ser Cys Thr Thr Asn Cys Leu Ala Pro Leu Ala
145                 150                 155                 160 
Lys Val Ile His Asp His Phe Gly Ile Val Glu Gly Leu Met Thr Thr
                165                 170                 175     
Val His Ala Ile Thr Ala Thr Gln Lys Thr Val Asp Ser Pro Ser Gly
            180                 185                 190         
Lys Leu Trp Arg Gly Gly Arg Gly Ala Ala Gln Asn Leu Ile Pro Ala
        195                 200                 205             
Ser Thr Gly Ala Ala Lys Ala Val Gly Lys Val Ile Pro Glu Leu Asp
    210                 215                 220                 
Gly Lys Leu Thr Gly Met Ala Phe Arg Val Pro Thr Ala Asn Val Ser
225                 230                 235                 240 
Val Leu Asp Leu Thr Cys Arg Leu Glu Lys Pro Ala Lys Tyr Asp Asp
                245                 250                 255     
Ile Lys Lys Val Val Lys Glu Ala Ser Glu Gly Pro Leu Lys Gly Ile
            260                 265                 270         
Leu Gly Tyr Thr Glu Asp Glu Val Val Ser Asp Asp Phe Asn Gly Ser
        275                 280                 285             
Asn His Ser Ser Ile Phe Asp Ala Gly Ala Gly Ile Glu Leu Asn Asp
    290                 295                 300                 
Thr Phe Val Lys Leu Val Ser Trp Tyr Asp Asn Glu Phe Gly Tyr Ser
305                 310                 315                 320 
Glu Arg Val Val Asp Leu Met Ala His Met Ala Ser Lys Glu
                325                 330                 


<210> 38
<211> 314
<212> PRT
<213> Homo sapiens

<400> 38
Met Ala Pro Pro Gln Val Leu Ala Phe Gly Leu Leu Leu Ala Ala Ala
 1               5                  10                  15      
Thr Ala Thr Phe Ala Ala Ala Gln Glu Glu Cys Val Cys Glu Asn Tyr
            20                  25                  30          
Lys Leu Ala Val Asn Cys Phe Val Asn Asn Asn Arg Gln Cys Gln Cys
        35                  40                  45              
Thr Ser Val Gly Ala Gln Asn Thr Val Ile Cys Ser Lys Leu Ala Ala
    50                  55                  60                  
Lys Cys Leu Val Met Lys Ala Glu Met Asn Gly Ser Lys Leu Gly Arg
65                  70                  75                  80  
Arg Ala Lys Pro Glu Gly Ala Leu Gln Asn Asn Asp Gly Leu Tyr Asp
                85                  90                  95      
Pro Asp Cys Asp Glu Ser Gly Leu Phe Lys Ala Lys Gln Cys Asn Gly
            100                 105                 110         
Thr Ser Thr Cys Trp Cys Val Asn Thr Ala Gly Val Arg Arg Thr Asp
        115                 120                 125             
Lys Asp Thr Glu Ile Thr Cys Ser Glu Arg Val Arg Thr Tyr Trp Ile
    130                 135                 140                 
Ile Ile Glu Leu Lys His Lys Ala Arg Glu Lys Pro Tyr Asp Ser Lys
145                 150                 155                 160 
Ser Leu Arg Thr Ala Leu Gln Lys Glu Ile Thr Thr Arg Tyr Gln Leu
                165                 170                 175     
Asp Pro Lys Phe Ile Thr Ser Ile Leu Tyr Glu Asn Asn Val Ile Thr
            180                 185                 190         
Ile Asp Leu Val Gln Asn Ser Ser Gln Lys Thr Gln Asn Asp Val Asp
        195                 200                 205             
Ile Ala Asp Val Ala Tyr Tyr Phe Glu Lys Asp Val Lys Gly Glu Ser
    210                 215                 220                 
Leu Phe His Ser Lys Lys Met Asp Leu Thr Val Asn Gly Glu Gln Leu
225                 230                 235                 240 
Asp Leu Asp Pro Gly Gln Thr Leu Ile Tyr Tyr Val Asp Glu Lys Ala
                245                 250                 255     
Pro Glu Phe Ser Met Gln Gly Leu Lys Ala Gly Val Ile Ala Val Ile
            260                 265                 270         
Val Val Val Val Met Ala Val Val Ala Gly Ile Val Val Leu Val Ile
        275                 280                 285             
Ser Arg Lys Lys Arg Met Ala Lys Tyr Glu Lys Ala Glu Ile Lys Glu
    290                 295                 300                 
Met Gly Glu Met His Arg Glu Leu Asn Ala
305                 310                 


<210> 39
<211> 201
<212> PRT
<213> Homo sapiens

<400> 39
Met Cys Ala Ala Arg Leu Ala Ala Ala Ala Ala Gln Ser Val Tyr Ala
 1               5                  10                  15      
Phe Ser Ala Arg Pro Leu Ala Gly Gly Glu Pro Val Ser Leu Gly Ser
            20                  25                  30          
Leu Arg Gly Lys Val Leu Leu Ile Glu Asn Val Ala Ser Leu Cys Gly
        35                  40                  45              
Thr Thr Val Arg Asp Tyr Thr Gln Met Asn Glu Leu Gln Arg Arg Leu
    50                  55                  60                  
Gly Pro Arg Gly Leu Val Val Leu Gly Phe Pro Cys Asn Gln Phe Gly
65                  70                  75                  80  
His Gln Glu Asn Ala Lys Asn Glu Glu Ile Leu Asn Ser Leu Lys Tyr
                85                  90                  95      
Val Arg Pro Gly Gly Gly Phe Glu Pro Asn Phe Met Leu Phe Glu Lys
            100                 105                 110         
Cys Glu Val Asn Gly Ala Gly Ala His Pro Leu Phe Ala Phe Leu Arg
        115                 120                 125             
Glu Ala Leu Pro Ala Pro Ser Asp Asp Ala Thr Ala Leu Met Thr Asp
    130                 135                 140                 
Pro Lys Leu Ile Thr Trp Ser Pro Val Cys Arg Asn Asp Val Ala Trp
145                 150                 155                 160 
Asn Phe Glu Lys Phe Leu Val Gly Pro Asp Gly Val Pro Leu Arg Arg
                165                 170                 175     
Tyr Ser Arg Arg Phe Gln Thr Ile Asp Ile Glu Pro Asp Ile Glu Ala
            180                 185                 190         
Leu Leu Ser Gln Gly Pro Ser Cys Ala
        195                 200     


<210> 40
<211> 153
<212> PRT
<213> Homo sapiens

<400> 40
Met Leu Ser Asn Cys Arg Gln Asn Thr Leu Gly His Asn Thr Gln Thr
 1               5                  10                  15      
Ser Ile Ala Gln Asp Phe Ser Ser Glu Gln Gly Arg Thr Ala Pro Gln
            20                  25                  30          
Asp Gln Lys Ala Ser Ile Gln Ile Tyr Pro Trp Met Gln Arg Met Asn
        35                  40                  45              
Ser His Ser Gly Val Gly Tyr Gly Ala Asp Arg Arg Arg Gly Arg Gln
    50                  55                  60                  
Ile Tyr Ser Arg Tyr Gln Thr Leu Glu Leu Glu Lys Glu Phe His Phe
65                  70                  75                  80  
Asn Arg Tyr Leu Thr Arg Arg Arg Arg Ile Glu Ile Ala Asn Ala Leu
                85                  90                  95      
Cys Leu Thr Glu Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met
            100                 105                 110         
Lys Trp Lys Lys Glu Ser Asn Leu Thr Ser Thr Leu Ser Gly Gly Gly
        115                 120                 125             
Gly Gly Ala Thr Ala Asp Ser Met Gly Gly Lys Glu Glu Lys Arg Glu
    130                 135                 140                 
Glu Thr Glu Glu Glu Lys Gln Lys Glu
145                 150             


<210> 41
<211> 199
<212> PRT
<213> Homo sapiens

<400> 41
Met Thr Glu Arg Arg Val Pro Phe Ser Leu Leu Arg Gly Pro Ser Trp
 1               5                  10                  15      
Asp Pro Phe Arg Asp Trp Tyr Pro His Ser Arg Leu Phe Asp Gln Ala
            20                  25                  30          
Phe Gly Leu Pro Arg Leu Pro Glu Glu Trp Ser Gln Trp Leu Gly Gly
        35                  40                  45              
Ser Ser Trp Pro Gly Tyr Val Arg Pro Leu Pro Pro Ala Ala Ile Glu
    50                  55                  60                  
Ser Pro Ala Val Ala Ala Pro Ala Tyr Ser Arg Ala Leu Ser Arg Gln
65                  70                  75                  80  
Leu Ser Ser Gly Val Ser Glu Ile Arg His Thr Ala Asp Arg Trp Arg
                85                  90                  95      
Val Ser Leu Asp Val Asn His Phe Ala Pro Asp Glu Leu Thr Val Lys
            100                 105                 110         
Thr Lys Asp Gly Val Val Glu Ile Thr Gly Lys His Glu Glu Arg Gln
        115                 120                 125             
Asp Glu His Gly Tyr Ile Ser Arg Cys Phe Thr Arg Lys Tyr Thr Leu
    130                 135                 140                 
Pro Pro Gly Val Asp Pro Thr Gln Val Ser Ser Ser Leu Ser Pro Glu
145                 150                 155                 160 
Gly Thr Leu Thr Val Glu Ala Pro Met Pro Lys Leu Ala Thr Gln Ser
                165                 170                 175     
Asn Glu Ile Thr Ile Pro Val Thr Phe Glu Ser Arg Ala Gln Leu Gly
            180                 185                 190         
Gly Arg Ser Cys Lys Ile Arg
        195                 


<210> 42
<211> 732
<212> PRT
<213> Homo sapiens

<400> 42
Met Pro Glu Glu Thr Gln Thr Gln Asp Gln Pro Met Glu Glu Glu Glu
 1               5                  10                  15      
Val Glu Thr Phe Ala Phe Gln Ala Glu Ile Ala Gln Leu Met Ser Leu
            20                  25                  30          
Ile Ile Asn Thr Phe Tyr Ser Asn Lys Glu Ile Phe Leu Arg Glu Leu
        35                  40                  45              
Ile Ser Asn Ser Ser Asp Ala Leu Asp Lys Ile Arg Tyr Glu Thr Leu
    50                  55                  60                  
Thr Asp Pro Ser Lys Leu Asp Ser Gly Lys Glu Leu His Ile Asn Leu
65                  70                  75                  80  
Ile Pro Asn Lys Gln Asp Arg Thr Leu Thr Ile Val Asp Thr Gly Ile
                85                  90                  95      
Gly Met Thr Lys Ala Asp Leu Ile Asn Asn Leu Gly Thr Ile Ala Lys
            100                 105                 110         
Ser Gly Thr Lys Ala Phe Met Glu Ala Leu Gln Ala Gly Ala Asp Ile
        115                 120                 125             
Ser Met Ile Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala Tyr Leu Val
    130                 135                 140                 
Ala Glu Lys Val Thr Val Ile Thr Lys His Asn Asp Asp Glu Gln Tyr
145                 150                 155                 160 
Ala Trp Glu Ser Ser Ala Gly Gly Ser Phe Thr Val Arg Thr Asp Thr
                165                 170                 175     
Gly Glu Pro Met Gly Arg Gly Thr Lys Val Ile Leu His Leu Lys Glu
            180                 185                 190         
Asp Gln Thr Glu Tyr Leu Glu Glu Arg Arg Ile Lys Glu Ile Val Lys
        195                 200                 205             
Lys His Ser Gln Phe Ile Gly Tyr Pro Ile Thr Leu Phe Val Glu Lys
    210                 215                 220                 
Glu Arg Asp Lys Glu Val Ser Asp Asp Glu Ala Glu Glu Lys Glu Asp
225                 230                 235                 240 
Lys Glu Glu Glu Lys Glu Lys Glu Glu Lys Glu Ser Glu Asp Lys Pro
                245                 250                 255     
Glu Ile Glu Asp Val Gly Ser Asp Glu Glu Glu Glu Lys Lys Asp Gly
            260                 265                 270         
Asp Lys Lys Lys Lys Lys Lys Ile Lys Glu Lys Tyr Ile Asp Gln Glu
        275                 280                 285             
Glu Leu Asn Lys Thr Lys Pro Ile Trp Thr Arg Asn Pro Asp Asp Ile
    290                 295                 300                 
Thr Asn Glu Glu Tyr Gly Glu Phe Tyr Lys Ser Leu Thr Asn Asp Trp
305                 310                 315                 320 
Glu Asp His Leu Ala Val Lys His Phe Ser Val Glu Gly Gln Leu Glu
                325                 330                 335     
Phe Arg Ala Leu Leu Phe Val Pro Arg Arg Ala Pro Phe Asp Leu Phe
            340                 345                 350         
Glu Asn Arg Lys Lys Lys Asn Asn Ile Lys Leu Tyr Val Arg Arg Val
        355                 360                 365             
Phe Ile Met Asp Asn Cys Glu Glu Leu Ile Pro Glu Tyr Leu Asn Phe
    370                 375                 380                 
Ile Arg Gly Val Val Asp Ser Glu Asp Leu Pro Leu Asn Ile Ser Arg
385                 390                 395                 400 
Glu Met Leu Gln Gln Ser Lys Ile Leu Lys Val Ile Arg Lys Asn Leu
                405                 410                 415     
Val Lys Lys Cys Leu Glu Leu Phe Thr Glu Leu Ala Glu Asp Lys Glu
            420                 425                 430         
Asn Tyr Lys Lys Phe Tyr Glu Gln Phe Ser Lys Asn Ile Lys Leu Gly
        435                 440                 445             
Ile His Glu Asp Ser Gln Asn Arg Lys Lys Leu Ser Glu Leu Leu Arg
    450                 455                 460                 
Tyr Tyr Thr Ser Ala Ser Gly Asp Glu Met Val Ser Leu Lys Asp Tyr
465                 470                 475                 480 
Cys Thr Arg Met Lys Glu Asn Gln Lys His Ile Tyr Tyr Ile Thr Gly
                485                 490                 495     
Glu Thr Lys Asp Gln Val Ala Asn Ser Ala Phe Val Glu Arg Leu Arg
            500                 505                 510         
Lys His Gly Leu Glu Val Ile Tyr Met Ile Glu Pro Ile Asp Glu Tyr
        515                 520                 525             
Cys Val Gln Gln Leu Lys Glu Phe Glu Gly Lys Thr Leu Val Ser Val
    530                 535                 540                 
Thr Lys Glu Gly Leu Glu Leu Pro Glu Asp Glu Glu Glu Lys Lys Lys
545                 550                 555                 560 
Gln Glu Glu Lys Lys Thr Lys Phe Glu Asn Leu Cys Lys Ile Met Lys
                565                 570                 575     
Asp Ile Leu Glu Lys Lys Val Glu Lys Val Val Val Ser Asn Arg Leu
            580                 585                 590         
Val Thr Ser Pro Cys Cys Ile Val Thr Ser Thr Tyr Gly Trp Thr Ala
        595                 600                 605             
Asn Met Glu Arg Ile Met Lys Ala Gln Ala Leu Arg Asp Asn Ser Thr
    610                 615                 620                 
Met Gly Tyr Met Ala Ala Lys Lys His Leu Glu Ile Asn Pro Asp His
625                 630                 635                 640 
Ser Ile Ile Glu Thr Leu Arg Gln Lys Ala Glu Ala Asp Lys Asn Asp
                645                 650                 655     
Lys Ser Val Lys Asp Leu Val Ile Leu Leu Tyr Glu Thr Ala Leu Leu
            660                 665                 670         
Ser Ser Gly Phe Ser Leu Glu Asp Pro Gln Thr His Ala Asn Arg Ile
        675                 680                 685             
Tyr Arg Met Ile Lys Leu Gly Leu Gly Ile Asp Glu Asp Asp Pro Thr
    690                 695                 700                 
Ala Asp Asp Thr Ser Ala Ala Val Thr Glu Glu Met Pro Pro Leu Glu
705                 710                 715                 720 
Gly Asp Asp Asp Thr Ser Arg Met Glu Glu Val Asp
                725                 730         


<210> 43
<211> 732
<212> PRT
<213> Homo sapiens

<400> 43
Met Pro Glu Glu Thr Gln Thr Gln Asp Gln Pro Met Glu Glu Glu Glu
 1               5                  10                  15      
Val Glu Thr Phe Ala Phe Gln Ala Glu Ile Ala Gln Leu Met Ser Leu
            20                  25                  30          
Ile Ile Asn Thr Phe Tyr Ser Asn Lys Glu Ile Phe Leu Arg Glu Leu
        35                  40                  45              
Ile Ser Asn Ser Ser Asp Ala Leu Asp Lys Ile Arg Tyr Glu Thr Leu
    50                  55                  60                  
Thr Asp Pro Ser Lys Leu Asp Ser Gly Lys Glu Leu His Ile Asn Leu
65                  70                  75                  80  
Ile Pro Asn Lys Gln Asp Arg Thr Leu Thr Ile Val Asp Thr Gly Ile
                85                  90                  95      
Gly Met Thr Lys Ala Asp Leu Ile Asn Asn Leu Gly Thr Ile Ala Lys
            100                 105                 110         
Ser Gly Thr Lys Ala Phe Met Glu Ala Leu Gln Ala Gly Ala Asp Ile
        115                 120                 125             
Ser Met Ile Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala Tyr Leu Val
    130                 135                 140                 
Ala Glu Lys Val Thr Val Ile Thr Lys His Asn Asp Asp Glu Gln Tyr
145                 150                 155                 160 
Ala Trp Glu Ser Ser Ala Gly Gly Ser Phe Thr Val Arg Thr Asp Thr
                165                 170                 175     
Gly Glu Pro Met Gly Arg Gly Thr Lys Val Ile Leu His Leu Lys Glu
            180                 185                 190         
Asp Gln Thr Glu Tyr Leu Glu Glu Arg Arg Ile Lys Glu Ile Val Lys
        195                 200                 205             
Lys His Ser Gln Phe Ile Gly Tyr Pro Ile Thr Leu Phe Val Glu Lys
    210                 215                 220                 
Glu Arg Asp Lys Glu Val Ser Asp Asp Glu Ala Glu Glu Lys Glu Asp
225                 230                 235                 240 
Lys Glu Glu Glu Lys Glu Lys Glu Glu Lys Glu Ser Glu Asp Lys Pro
                245                 250                 255     
Glu Ile Glu Asp Val Gly Ser Asp Glu Glu Glu Glu Lys Lys Asp Gly
            260                 265                 270         
Asp Lys Lys Lys Lys Lys Lys Ile Lys Glu Lys Tyr Ile Asp Gln Glu
        275                 280                 285             
Glu Leu Asn Lys Thr Lys Pro Ile Trp Thr Arg Asn Pro Asp Asp Ile
    290                 295                 300                 
Thr Asn Glu Glu Tyr Gly Glu Phe Tyr Lys Ser Leu Thr Asn Asp Trp
305                 310                 315                 320 
Glu Asp His Leu Ala Val Lys His Phe Ser Val Glu Gly Gln Leu Glu
                325                 330                 335     
Phe Arg Ala Leu Leu Phe Val Pro Arg Arg Ala Pro Phe Asp Leu Phe
            340                 345                 350         
Glu Asn Arg Lys Lys Lys Asn Asn Ile Lys Leu Tyr Val Arg Arg Val
        355                 360                 365             
Phe Ile Met Asp Asn Cys Glu Glu Leu Ile Pro Glu Tyr Leu Asn Phe
    370                 375                 380                 
Ile Arg Gly Val Val Asp Ser Glu Asp Leu Pro Leu Asn Ile Ser Arg
385                 390                 395                 400 
Glu Met Leu Gln Gln Ser Lys Ile Leu Lys Val Ile Arg Lys Asn Leu
                405                 410                 415     
Val Lys Lys Cys Leu Glu Leu Phe Thr Glu Leu Ala Glu Asp Lys Glu
            420                 425                 430         
Asn Tyr Lys Lys Phe Tyr Glu Gln Phe Ser Lys Asn Ile Lys Leu Gly
        435                 440                 445             
Ile His Glu Asp Ser Gln Asn Arg Lys Lys Leu Ser Glu Leu Leu Arg
    450                 455                 460                 
Tyr Tyr Thr Ser Ala Ser Gly Asp Glu Met Val Ser Leu Lys Asp Tyr
465                 470                 475                 480 
Cys Thr Arg Met Lys Glu Asn Gln Lys His Ile Tyr Tyr Ile Thr Gly
                485                 490                 495     
Glu Thr Lys Asp Gln Val Ala Asn Ser Ala Phe Val Glu Arg Leu Arg
            500                 505                 510         
Lys His Gly Leu Glu Val Ile Tyr Met Ile Glu Pro Ile Asp Glu Tyr
        515                 520                 525             
Cys Val Gln Gln Leu Lys Glu Phe Glu Gly Lys Thr Leu Val Ser Val
    530                 535                 540                 
Thr Lys Glu Gly Leu Glu Leu Pro Glu Asp Glu Glu Glu Lys Lys Lys
545                 550                 555                 560 
Gln Glu Glu Lys Lys Thr Lys Phe Glu Asn Leu Cys Lys Ile Met Lys
                565                 570                 575     
Asp Ile Leu Glu Lys Lys Val Glu Lys Val Val Val Ser Asn Arg Leu
            580                 585                 590         
Val Thr Ser Pro Cys Cys Ile Val Thr Ser Thr Tyr Gly Trp Thr Ala
        595                 600                 605             
Asn Met Glu Arg Ile Met Lys Ala Gln Ala Leu Arg Asp Asn Ser Thr
    610                 615                 620                 
Met Gly Tyr Met Ala Ala Lys Lys His Leu Glu Ile Asn Pro Asp His
625                 630                 635                 640 
Ser Ile Ile Glu Thr Leu Arg Gln Lys Ala Glu Ala Asp Lys Asn Asp
                645                 650                 655     
Lys Ser Val Lys Asp Leu Val Ile Leu Leu Tyr Glu Thr Ala Leu Leu
            660                 665                 670         
Ser Ser Gly Phe Ser Leu Glu Asp Pro Gln Thr His Ala Asn Arg Ile
        675                 680                 685             
Tyr Arg Met Ile Lys Leu Gly Leu Gly Ile Asp Glu Asp Asp Pro Thr
    690                 695                 700                 
Ala Asp Asp Thr Ser Ala Ala Val Thr Glu Glu Met Pro Pro Leu Glu
705                 710                 715                 720 
Gly Asp Asp Asp Thr Ser Arg Met Glu Glu Val Asp
                725                 730         


<210> 44
<211> 1390
<212> PRT
<213> Homo sapiens

<400> 44
Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe
 1               5                  10                  15      
Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys
            20                  25                  30          
Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala
        35                  40                  45              
Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu
    50                  55                  60                  
Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys
65                  70                  75                  80  
Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe
                85                  90                  95      
Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp
            100                 105                 110         
Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp
        115                 120                 125             
Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His
    130                 135                 140                 
Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys
145                 150                 155                 160 
Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val
                165                 170                 175     
Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe
            180                 185                 190         
Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp
        195                 200                 205             
His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp
    210                 215                 220                 
Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu
225                 230                 235                 240 
Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn
                245                 250                 255     
Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln
            260                 265                 270         
Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu
        275                 280                 285             
His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg
    290                 295                 300                 
Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala
305                 310                 315                 320 
Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser
                325                 330                 335     
Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp
            340                 345                 350         
Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys
        355                 360                 365             
Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg
    370                 375                 380                 
Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg
385                 390                 395                 400 
Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr
                405                 410                 415     
Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly
            420                 425                 430         
Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly
        435                 440                 445             
Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln
    450                 455                 460                 
Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu
465                 470                 475                 480 
Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu
                485                 490                 495     
Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys
            500                 505                 510         
Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln
        515                 520                 525             
Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys
    530                 535                 540                 
Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile
545                 550                 555                 560 
Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu
                565                 570                 575     
Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg
            580                 585                 590         
Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu
        595                 600                 605             
Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys
    610                 615                 620                 
Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile
625                 630                 635                 640 
Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp
                645                 650                 655     
Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly
            660                 665                 670         
Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg
        675                 680                 685             
His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn
    690                 695                 700                 
Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Phe
705                 710                 715                 720 
Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe
                725                 730                 735     
Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser
            740                 745                 750         
Phe Ile Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn Leu Asn
        755                 760                 765             
Ser Val Ser Val Pro Arg Met Val Ile Asn Val His Glu Ala Gly Arg
    770                 775                 780                 
Asn Phe Thr Val Ala Cys Gln His Arg Ser Asn Ser Glu Ile Ile Cys
785                 790                 795                 800 
Cys Thr Thr Pro Ser Leu Gln Gln Leu Asn Leu Gln Leu Pro Leu Lys
                805                 810                 815     
Thr Lys Ala Phe Phe Met Leu Asp Gly Ile Leu Ser Lys Tyr Phe Asp
            820                 825                 830         
Leu Ile Tyr Val His Asn Pro Val Phe Lys Pro Phe Glu Lys Pro Val
        835                 840                 845             
Met Ile Ser Met Gly Asn Glu Asn Val Leu Glu Ile Lys Gly Asn Asp
    850                 855                 860                 
Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly Asn Lys
865                 870                 875                 880 
Ser Cys Glu Asn Ile His Leu His Ser Glu Ala Val Leu Cys Thr Val
                885                 890                 895     
Pro Asn Asp Leu Leu Lys Leu Asn Ser Glu Leu Asn Ile Glu Trp Lys
            900                 905                 910         
Gln Ala Ile Ser Ser Thr Val Leu Gly Lys Val Ile Val Gln Pro Asp
        915                 920                 925             
Gln Asn Phe Thr Gly Leu Ile Ala Gly Val Val Ser Ile Ser Thr Ala
    930                 935                 940                 
Leu Leu Leu Leu Leu Gly Phe Phe Leu Trp Leu Lys Lys Arg Lys Gln
945                 950                 955                 960 
Ile Lys Asp Leu Gly Ser Glu Leu Val Arg Tyr Asp Ala Arg Val His
                965                 970                 975     
Thr Pro His Leu Asp Arg Leu Val Ser Ala Arg Ser Val Ser Pro Thr
            980                 985                 990         
Thr Glu Met Val Ser Asn Glu Ser Val Asp Tyr Arg Ala Thr Phe Pro
        995                 1000                1005            
Glu Asp Gln Phe Pro Asn Ser Ser Gln Asn Gly Ser Cys Arg Gln Val
    1010                1015                1020                
Gln Tyr Pro Leu Thr Asp Met Ser Pro Ile Leu Thr Ser Gly Asp Ser
1025                1030                1035                1040
Asp Ile Ser Ser Pro Leu Leu Gln Asn Thr Val His Ile Asp Leu Ser
                1045                1050                1055    
Ala Leu Asn Pro Glu Leu Val Gln Ala Val Gln His Val Val Ile Gly
            1060                1065                1070        
Pro Ser Ser Leu Ile Val His Phe Asn Glu Val Ile Gly Arg Gly His
        1075                1080                1085            
Phe Gly Cys Val Tyr His Gly Thr Leu Leu Asp Asn Asp Gly Lys Lys
    1090                1095                1100                
Ile His Cys Ala Val Lys Ser Leu Asn Arg Ile Thr Asp Ile Gly Glu
1105                1110                1115                1120
Val Ser Gln Phe Leu Thr Glu Gly Ile Ile Met Lys Asp Phe Ser His
                1125                1130                1135    
Pro Asn Val Leu Ser Leu Leu Gly Ile Cys Leu Arg Ser Glu Gly Ser
            1140                1145                1150        
Pro Leu Val Val Leu Pro Tyr Met Lys His Gly Asp Leu Arg Asn Phe
        1155                1160                1165            
Ile Arg Asn Glu Thr His Asn Pro Thr Val Lys Asp Leu Ile Gly Phe
    1170                1175                1180                
Gly Leu Gln Val Ala Lys Gly Met Lys Tyr Leu Ala Ser Lys Lys Phe
1185                1190                1195                1200
Val His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Asp Glu Lys Phe
                1205                1210                1215    
Thr Val Lys Val Ala Asp Phe Gly Leu Ala Arg Asp Met Tyr Asp Lys
            1220                1225                1230        
Glu Tyr Tyr Ser Val His Asn Lys Thr Gly Ala Lys Leu Pro Val Lys
        1235                1240                1245            
Trp Met Ala Leu Glu Ser Leu Gln Thr Gln Lys Phe Thr Thr Lys Ser
    1250                1255                1260                
Asp Val Trp Ser Phe Gly Val Val Leu Trp Glu Leu Met Thr Arg Gly
1265                1270                1275                1280
Ala Pro Pro Tyr Pro Asp Val Asn Thr Phe Asp Ile Thr Val Tyr Leu
                1285                1290                1295    
Leu Gln Gly Arg Arg Leu Leu Gln Pro Glu Tyr Cys Pro Asp Pro Leu
            1300                1305                1310        
Tyr Glu Val Met Leu Lys Cys Trp His Pro Lys Ala Glu Met Arg Pro
        1315                1320                1325            
Ser Phe Ser Glu Leu Val Ser Arg Ile Ser Ala Ile Phe Ser Thr Phe
    1330                1335                1340                
Ile Gly Glu His Tyr Val His Val Asn Ala Thr Tyr Val Asn Val Lys
1345                1350                1355                1360
Cys Val Ala Pro Tyr Pro Ser Leu Leu Ser Ser Glu Asp Asn Ala Asp
                1365                1370                1375    
Asp Glu Val Asp Thr Arg Pro Ala Ser Phe Trp Glu Thr Ser
            1380                1385                1390


<210> 45
<211> 359
<212> PRT
<213> Homo sapiens

<400> 45
Met Ala Ala Val Ser Gly Leu Val Arg Arg Pro Leu Arg Glu Val Ser
 1               5                  10                  15      
Gly Leu Leu Lys Arg Arg Phe His Trp Thr Ala Pro Ala Ala Val Gln
            20                  25                  30          
Val Thr Val Arg Asp Ala Ile Asn Gln Gly Met Asp Glu Glu Leu Glu
        35                  40                  45              
Arg Asp Glu Lys Val Phe Leu Leu Gly Glu Glu Val Ala Gln Tyr Asp
    50                  55                  60                  
Gly Ala Tyr Lys Val Ser Arg Gly Leu Trp Lys Lys Tyr Gly Asp Lys
65                  70                  75                  80  
Arg Ile Ile Asp Thr Pro Ile Ser Glu Met Gly Phe Ala Gly Ile Ala
                85                  90                  95      
Val Gly Ala Ala Met Ala Gly Leu Arg Pro Ile Cys Glu Phe Met Thr
            100                 105                 110         
Phe Asn Phe Ser Met Gln Ala Ile Asp Gln Val Ile Asn Ser Ala Ala
        115                 120                 125             
Lys Thr Tyr Tyr Met Ser Gly Gly Leu Gln Pro Val Pro Ile Val Phe
    130                 135                 140                 
Arg Gly Pro Asn Gly Ala Ser Ala Gly Val Ala Ala Gln His Ser Gln
145                 150                 155                 160 
Cys Phe Ala Ala Trp Tyr Gly His Cys Pro Gly Leu Lys Val Val Ser
                165                 170                 175     
Pro Trp Asn Ser Glu Asp Ala Lys Gly Leu Ile Lys Ser Ala Ile Arg
            180                 185                 190         
Asp Asn Asn Pro Val Val Val Leu Glu Asn Glu Leu Met Tyr Gly Val
        195                 200                 205             
Pro Phe Glu Phe Pro Pro Glu Ala Gln Ser Lys Asp Phe Leu Ile Pro
    210                 215                 220                 
Ile Gly Lys Ala Lys Ile Glu Arg Gln Gly Thr His Ile Thr Val Val
225                 230                 235                 240 
Ser His Ser Arg Pro Val Gly His Cys Leu Glu Ala Ala Ala Val Leu
                245                 250                 255     
Ser Lys Glu Gly Val Glu Cys Glu Val Ile Asn Met Arg Thr Ile Arg
            260                 265                 270         
Pro Met Asp Met Glu Thr Ile Glu Ala Ser Val Met Lys Thr Asn His
        275                 280                 285             
Leu Val Thr Val Glu Gly Gly Trp Pro Gln Phe Gly Val Gly Ala Glu
    290                 295                 300                 
Ile Cys Ala Arg Ile Met Glu Gly Pro Ala Phe Asn Phe Leu Asp Ala
305                 310                 315                 320 
Pro Ala Val Arg Val Thr Gly Ala Asp Val Pro Met Pro Tyr Ala Lys
                325                 330                 335     
Ile Leu Glu Asp Asn Ser Ile Pro Gln Val Lys Asp Ile Ile Phe Ala
            340                 345                 350         
Ile Lys Lys Thr Leu Asn Ile
        355                 


<210> 46
<211> 573
<212> PRT
<213> Homo sapiens

<400> 46
Met Leu Arg Leu Pro Thr Val Phe Arg Gln Met Arg Pro Val Ser Arg
 1               5                  10                  15      
Val Leu Ala Pro His Leu Thr Arg Ala Tyr Ala Lys Asp Val Lys Phe
            20                  25                  30          
Gly Ala Asp Ala Arg Ala Leu Met Leu Gln Gly Val Asp Leu Leu Ala
        35                  40                  45              
Asp Ala Val Ala Val Thr Met Gly Pro Lys Gly Arg Thr Val Ile Ile
    50                  55                  60                  
Glu Gln Ser Trp Gly Ser Pro Lys Val Thr Lys Asp Gly Val Thr Val
65                  70                  75                  80  
Ala Lys Ser Ile Asp Leu Lys Asp Lys Tyr Lys Asn Ile Gly Ala Lys
                85                  90                  95      
Leu Val Gln Asp Val Ala Asn Asn Thr Asn Glu Glu Ala Gly Asp Gly
            100                 105                 110         
Thr Thr Thr Ala Thr Val Leu Ala Arg Ser Ile Ala Lys Glu Gly Phe
        115                 120                 125             
Glu Lys Ile Ser Lys Gly Ala Asn Pro Val Glu Ile Arg Arg Gly Val
    130                 135                 140                 
Met Leu Ala Val Asp Ala Val Ile Ala Glu Leu Lys Lys Gln Ser Lys
145                 150                 155                 160 
Pro Val Thr Thr Pro Glu Glu Ile Ala Gln Val Ala Thr Ile Ser Ala
                165                 170                 175     
Asn Gly Asp Lys Glu Ile Gly Asn Ile Ile Ser Asp Ala Met Lys Lys
            180                 185                 190         
Val Gly Arg Lys Gly Val Ile Thr Val Lys Asp Gly Lys Thr Leu Asn
        195                 200                 205             
Asp Glu Leu Glu Ile Ile Glu Gly Met Lys Phe Asp Arg Gly Tyr Ile
    210                 215                 220                 
Ser Pro Tyr Phe Ile Asn Thr Ser Lys Gly Gln Lys Cys Glu Phe Gln
225                 230                 235                 240 
Asp Ala Tyr Val Leu Leu Ser Glu Lys Lys Ile Ser Ser Ile Gln Ser
                245                 250                 255     
Ile Val Pro Ala Leu Glu Ile Ala Asn Ala His Arg Lys Pro Leu Val
            260                 265                 270         
Ile Ile Ala Glu Asp Val Asp Gly Glu Ala Leu Ser Thr Leu Val Leu
        275                 280                 285             
Asn Arg Leu Lys Val Gly Leu Gln Val Val Ala Val Lys Ala Pro Gly
    290                 295                 300                 
Phe Gly Asp Asn Arg Lys Asn Gln Leu Lys Asp Met Ala Ile Ala Thr
305                 310                 315                 320 
Gly Gly Ala Val Phe Gly Glu Glu Gly Leu Thr Leu Asn Leu Glu Asp
                325                 330                 335     
Val Gln Pro His Asp Leu Gly Lys Val Gly Glu Val Ile Val Thr Lys
            340                 345                 350         
Asp Asp Ala Met Leu Leu Lys Gly Lys Gly Asp Lys Ala Gln Ile Glu
        355                 360                 365             
Lys Arg Ile Gln Glu Ile Ile Glu Gln Leu Asp Val Thr Thr Ser Glu
    370                 375                 380                 
Tyr Glu Lys Glu Lys Leu Asn Glu Arg Leu Ala Lys Leu Ser Asp Gly
385                 390                 395                 400 
Val Ala Val Leu Lys Val Gly Gly Thr Ser Asp Val Glu Val Asn Glu
                405                 410                 415     
Lys Lys Asp Arg Val Thr Asp Ala Leu Asn Ala Thr Arg Ala Ala Val
            420                 425                 430         
Glu Glu Gly Ile Val Leu Gly Gly Gly Cys Ala Leu Leu Arg Cys Ile
        435                 440                 445             
Pro Ala Leu Asp Ser Leu Thr Pro Ala Asn Glu Asp Gln Lys Ile Gly
    450                 455                 460                 
Ile Glu Ile Ile Lys Arg Thr Leu Lys Ile Pro Ala Met Thr Ile Ala
465                 470                 475                 480 
Lys Asn Ala Gly Val Glu Gly Ser Leu Ile Val Glu Lys Ile Met Gln
                485                 490                 495     
Ser Ser Ser Glu Val Gly Tyr Asp Ala Met Ala Gly Asp Phe Val Asn
            500                 505                 510         
Met Val Glu Lys Gly Ile Ile Asp Pro Thr Lys Val Val Arg Thr Ala
        515                 520                 525             
Leu Leu Asp Ala Ala Gly Val Ala Ser Leu Leu Thr Thr Ala Glu Val
    530                 535                 540                 
Val Val Thr Glu Ile Pro Lys Glu Glu Lys Asp Pro Gly Met Gly Ala
545                 550                 555                 560 
Met Gly Gly Met Gly Gly Gly Met Gly Gly Gly Met Phe
                565                 570             


<210> 47
<211> 418
<212> PRT
<213> Homo sapiens

<400> 47
Met Ser Leu Ser Asn Lys Leu Thr Leu Asp Lys Leu Asp Val Lys Gly
 1               5                  10                  15      
Lys Arg Val Val Met Arg Val Asp Phe Asn Val Pro Met Lys Asn Asn
            20                  25                  30          
Gln Ile Thr Asn Asn Gln Arg Ile Lys Ala Ala Val Pro Ser Ile Lys
        35                  40                  45              
Phe Cys Leu Asp Asn Gly Ala Lys Ser Val Val Leu Met Ser His Leu
    50                  55                  60                  
Gly Arg Pro Asp Gly Val Pro Met Pro Asp Lys Tyr Ser Leu Glu Pro
65                  70                  75                  80  
Val Ala Val Glu Leu Lys Ser Leu Leu Gly Lys Asp Val Leu Phe Leu
                85                  90                  95      
Lys Asp Cys Val Gly Pro Glu Val Glu Lys Ala Cys Ala Asn Pro Ala
            100                 105                 110         
Ala Gly Ser Val Ile Leu Leu Glu Asn Leu Arg Phe His Val Glu Glu
        115                 120                 125             
Glu Gly Lys Gly Lys Asp Ala Ser Gly Asn Lys Val Lys Ala Glu Pro
    130                 135                 140                 
Ala Lys Ile Glu Ala Phe Arg Ala Ser Leu Ser Lys Leu Gly Asp Val
145                 150                 155                 160 
Tyr Val Asn Asp Ala Phe Gly Thr Ala His Arg Ala His Ser Ser Met
                165                 170                 175     
Val Gly Val Asn Leu Pro Gln Lys Ala Gly Gly Phe Leu Met Lys Lys
            180                 185                 190         
Glu Leu Asn Tyr Phe Ala Lys Ala Leu Glu Ser Pro Glu Arg Pro Phe
        195                 200                 205             
Leu Ala Ile Leu Gly Gly Ala Lys Val Ala Asp Lys Ile Gln Leu Ile
    210                 215                 220                 
Asn Asn Met Leu Asp Lys Val Asn Glu Met Ile Ile Gly Gly Gly Met
225                 230                 235                 240 
Ala Phe Thr Phe Leu Lys Val Leu Asn Asn Met Glu Ile Gly Thr Ser
                245                 250                 255     
Leu Phe Asp Glu Glu Gly Ala Lys Ile Val Lys Asp Leu Met Ser Lys
            260                 265                 270         
Ala Glu Lys Asn Gly Val Lys Ile Thr Leu Pro Val Asp Phe Val Thr
        275                 280                 285             
Ala Asp Lys Phe Asp Glu Asn Ala Lys Thr Gly Gln Ala Thr Val Ala
    290                 295                 300                 
Ser Gly Ile Pro Ala Gly Trp Met Gly Leu Asp Cys Gly Pro Glu Ser
305                 310                 315                 320 
Ser Lys Lys Tyr Ala Glu Ala Val Thr Arg Ala Lys Gln Ile Val Trp
                325                 330                 335     
Asn Gly Pro Val Gly Val Phe Glu Trp Glu Ala Phe Ala Arg Gly Thr
            340                 345                 350         
Lys Ala Leu Met Asp Glu Val Val Lys Ala Thr Ser Arg Gly Cys Ile
        355                 360                 365             
Thr Ile Ile Gly Gly Gly Asp Thr Ala Thr Cys Cys Ala Lys Trp Asn
    370                 375                 380                 
Thr Glu Asp Lys Val Ser His Val Ser Thr Gly Gly Gly Ala Ser Leu
385                 390                 395                 400 
Glu Leu Leu Glu Gly Lys Val Leu Pro Gly Val Asp Ala Leu Ser Asn
                405                 410                 415     
Ile Leu
        


<210> 48
<211> 524
<212> PRT
<213> Homo sapiens

<400> 48
Met Ile Ser Pro Phe Leu Val Leu Ala Ile Gly Thr Cys Leu Thr Asn
 1               5                  10                  15      
Ser Leu Val Pro Glu Lys Glu Lys Asp Pro Lys Tyr Trp Arg Asp Gln
            20                  25                  30          
Ala Gln Glu Thr Leu Lys Tyr Ala Leu Glu Leu Gln Lys Leu Asn Thr
        35                  40                  45              
Asn Val Ala Lys Asn Val Ile Met Phe Leu Gly Asp Gly Met Gly Val
    50                  55                  60                  
Ser Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Leu His His Asn
65                  70                  75                  80  
Pro Gly Glu Glu Thr Arg Leu Glu Met Asp Lys Phe Pro Phe Val Ala
                85                  90                  95      
Leu Ser Lys Thr Tyr Asn Thr Lys Ala Gln Val Pro Asp Ser Ala Gly
            100                 105                 110         
Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Glu Gly Thr Val
        115                 120                 125             
Gly Val Ser Ala Ala Thr Glu Arg Ser Arg Cys Asn Thr Thr Gln Gly
    130                 135                 140                 
Asn Glu Val Thr Ser Ile Leu Arg Trp Ala Lys Asp Ala Gly Lys Ser
145                 150                 155                 160 
Val Gly Ile Val Thr Thr Thr Arg Val Asn His Ala Thr Pro Ser Ala
                165                 170                 175     
Ala Tyr Ala His Ser Ala Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met
            180                 185                 190         
Pro Pro Glu Ala Leu Ser Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu
        195                 200                 205             
Met His Asn Ile Arg Asp Ile Asp Val Ile Met Gly Gly Gly Arg Lys
    210                 215                 220                 
Tyr Met Tyr Pro Lys Asn Lys Thr Asp Val Glu Tyr Glu Ser Asp Glu
225                 230                 235                 240 
Lys Ala Arg Gly Thr Arg Leu Asp Gly Leu Asp Leu Val Asp Thr Trp
                245                 250                 255     
Lys Ser Phe Lys Pro Arg His Lys His Ser His Phe Ile Trp Asn Arg
            260                 265                 270         
Thr Glu Leu Leu Thr Leu Asp Pro His Asn Val Asp Tyr Leu Leu Gly
        275                 280                 285             
Leu Phe Glu Pro Gly Asp Met Gln Tyr Glu Leu Asn Arg Asn Asn Val
    290                 295                 300                 
Thr Asp Pro Ser Leu Ser Glu Met Val Val Val Ala Ile Gln Ile Leu
305                 310                 315                 320 
Arg Lys Asn Pro Lys Gly Phe Phe Leu Leu Val Glu Gly Gly Arg Ile
                325                 330                 335     
Asp His Gly His His Glu Gly Lys Ala Lys Gln Ala Leu His Glu Ala
            340                 345                 350         
Val Glu Met Asp Arg Ala Ile Gly Gln Ala Gly Ser Leu Thr Ser Ser
        355                 360                 365             
Glu Asp Thr Leu Thr Val Val Thr Ala Asp His Ser His Val Phe Thr
    370                 375                 380                 
Phe Gly Gly Tyr Thr Pro Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro
385                 390                 395                 400 
Met Leu Ser Asp Thr Asp Lys Lys Pro Phe Thr Ala Ile Leu Tyr Gly
                405                 410                 415     
Asn Gly Pro Gly Tyr Lys Val Val Gly Gly Glu Arg Glu Asn Val Ser
            420                 425                 430         
Met Val Asp Tyr Ala His Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro
        435                 440                 445             
Leu Arg His Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ser Lys
    450                 455                 460                 
Gly Pro Met Ala His Leu Leu His Gly Val His Glu Gln Asn Tyr Val
465                 470                 475                 480 
Pro His Val Met Ala Tyr Ala Ala Cys Ile Gly Ala Asn Leu Gly His
                485                 490                 495     
Cys Ala Pro Ala Ser Ser Ala Gly Ser Leu Ala Ala Gly Pro Leu Leu
            500                 505                 510         
Leu Ala Leu Ala Leu Tyr Pro Leu Ser Val Leu Phe
        515                 520                 


<210> 49
<211> 928
<212> PRT
<213> Homo sapiens

<400> 49
Met Pro Pro Lys Thr Pro Arg Lys Thr Ala Ala Thr Ala Ala Ala Ala
 1               5                  10                  15      
Ala Ala Glu Pro Pro Ala Pro Pro Pro Pro Pro Pro Pro Glu Glu Asp
            20                  25                  30          
Pro Glu Gln Asp Ser Gly Pro Glu Asp Leu Pro Leu Val Arg Leu Glu
        35                  40                  45              
Phe Glu Glu Thr Glu Glu Pro Asp Phe Thr Ala Leu Cys Gln Lys Leu
    50                  55                  60                  
Lys Ile Pro Asp His Val Arg Glu Arg Ala Trp Leu Thr Trp Glu Lys
65                  70                  75                  80  
Val Ser Ser Val Asp Gly Val Leu Gly Gly Tyr Ile Gln Lys Lys Lys
                85                  90                  95      
Glu Leu Trp Gly Ile Cys Ile Phe Ile Ala Ala Val Asp Leu Asp Glu
            100                 105                 110         
Met Ser Phe Thr Phe Thr Glu Leu Gln Lys Asn Ile Glu Ile Ser Val
        115                 120                 125             
His Lys Phe Phe Asn Leu Leu Lys Glu Ile Asp Thr Ser Thr Lys Val
    130                 135                 140                 
Asp Asn Ala Met Ser Arg Leu Leu Lys Lys Tyr Asp Val Leu Phe Ala
145                 150                 155                 160 
Leu Phe Ser Lys Leu Glu Arg Thr Cys Glu Leu Ile Tyr Leu Thr Gln
                165                 170                 175     
Pro Ser Ser Ser Ile Ser Thr Glu Ile Asn Ser Ala Leu Val Leu Lys
            180                 185                 190         
Val Ser Trp Ile Thr Phe Leu Leu Ala Lys Gly Glu Val Leu Gln Met
        195                 200                 205             
Glu Asp Asp Leu Val Ile Ser Phe Gln Leu Met Leu Cys Val Leu Asp
    210                 215                 220                 
Tyr Phe Ile Lys Leu Ser Pro Pro Met Leu Leu Lys Glu Pro Tyr Lys
225                 230                 235                 240 
Thr Ala Val Ile Pro Ile Asn Gly Ser Pro Arg Thr Pro Arg Arg Gly
                245                 250                 255     
Gln Asn Arg Ser Ala Arg Ile Ala Lys Gln Leu Glu Asn Asp Thr Arg
            260                 265                 270         
Ile Ile Glu Val Leu Cys Lys Glu His Glu Cys Asn Ile Asp Glu Val
        275                 280                 285             
Lys Asn Val Tyr Phe Lys Asn Phe Ile Pro Phe Met Asn Ser Leu Gly
    290                 295                 300                 
Leu Val Thr Ser Asn Gly Leu Pro Glu Val Glu Asn Leu Ser Lys Arg
305                 310                 315                 320 
Tyr Glu Glu Ile Tyr Leu Lys Asn Lys Asp Leu Asp Ala Arg Leu Phe
                325                 330                 335     
Leu Asp His Asp Lys Thr Leu Gln Thr Asp Ser Ile Asp Ser Phe Glu
            340                 345                 350         
Thr Gln Arg Thr Pro Arg Lys Ser Asn Leu Asp Glu Glu Val Asn Val
        355                 360                 365             
Ile Pro Pro His Thr Pro Val Arg Thr Val Met Asn Thr Ile Gln Gln
    370                 375                 380                 
Leu Met Met Ile Leu Asn Ser Ala Ser Asp Gln Pro Ser Glu Asn Leu
385                 390                 395                 400 
Ile Ser Tyr Phe Asn Asn Cys Thr Val Asn Pro Lys Glu Ser Ile Leu
                405                 410                 415     
Lys Arg Val Lys Asp Ile Gly Tyr Ile Phe Lys Glu Lys Phe Ala Lys
            420                 425                 430         
Ala Val Gly Gln Gly Cys Val Glu Ile Gly Ser Gln Arg Tyr Lys Leu
        435                 440                 445             
Gly Val Arg Leu Tyr Tyr Arg Val Met Glu Ser Met Leu Lys Ser Glu
    450                 455                 460                 
Glu Glu Arg Leu Ser Ile Gln Asn Phe Ser Lys Leu Leu Asn Asp Asn
465                 470                 475                 480 
Ile Phe His Met Ser Leu Leu Ala Cys Ala Leu Glu Val Val Met Ala
                485                 490                 495     
Thr Tyr Ser Arg Ser Thr Ser Gln Asn Leu Asp Ser Gly Thr Asp Leu
            500                 505                 510         
Ser Phe Pro Trp Ile Leu Asn Val Leu Asn Leu Lys Ala Phe Asp Phe
        515                 520                 525             
Tyr Lys Val Ile Glu Ser Phe Ile Lys Ala Glu Gly Asn Leu Thr Arg
    530                 535                 540                 
Glu Met Ile Lys His Leu Glu Arg Cys Glu His Arg Ile Met Glu Ser
545                 550                 555                 560 
Leu Ala Trp Leu Ser Asp Ser Pro Leu Phe Asp Leu Ile Lys Gln Ser
                565                 570                 575     
Lys Asp Arg Glu Gly Pro Thr Asp His Leu Glu Ser Ala Cys Pro Leu
            580                 585                 590         
Asn Leu Pro Leu Gln Asn Asn His Thr Ala Ala Asp Met Tyr Leu Ser
        595                 600                 605             
Pro Val Arg Ser Pro Lys Lys Lys Gly Ser Thr Thr Arg Val Asn Ser
    610                 615                 620                 
Thr Ala Asn Ala Glu Thr Gln Ala Thr Ser Ala Phe Gln Thr Gln Lys
625                 630                 635                 640 
Pro Leu Lys Ser Thr Ser Leu Ser Leu Phe Tyr Lys Lys Val Tyr Arg
                645                 650                 655     
Leu Ala Tyr Leu Arg Leu Asn Thr Leu Cys Glu Arg Leu Leu Ser Glu
            660                 665                 670         
His Pro Glu Leu Glu His Ile Ile Trp Thr Leu Phe Gln His Thr Leu
        675                 680                 685             
Gln Asn Glu Tyr Glu Leu Met Arg Asp Arg His Leu Asp Gln Ile Met
    690                 695                 700                 
Met Cys Ser Met Tyr Gly Ile Cys Lys Val Lys Asn Ile Asp Leu Lys
705                 710                 715                 720 
Phe Lys Ile Ile Val Thr Ala Tyr Lys Asp Leu Pro His Ala Val Gln
                725                 730                 735     
Glu Thr Phe Lys Arg Val Leu Ile Lys Glu Glu Glu Tyr Asp Ser Ile
            740                 745                 750         
Ile Val Phe Tyr Asn Ser Val Phe Met Gln Arg Leu Lys Thr Asn Ile
        755                 760                 765             
Leu Gln Tyr Ala Ser Thr Arg Pro Pro Thr Leu Ser Pro Ile Pro His
    770                 775                 780                 
Ile Pro Arg Ser Pro Tyr Lys Phe Pro Ser Ser Pro Leu Arg Ile Pro
785                 790                 795                 800 
Gly Gly Asn Ile Tyr Ile Ser Pro Leu Lys Ser Pro Tyr Lys Ile Ser
                805                 810                 815     
Glu Gly Leu Pro Thr Pro Thr Lys Met Thr Pro Arg Ser Arg Ile Leu
            820                 825                 830         
Val Ser Ile Gly Glu Ser Phe Gly Thr Ser Glu Lys Phe Gln Lys Ile
        835                 840                 845             
Asn Gln Met Val Cys Asn Ser Asp Arg Val Leu Lys Arg Ser Ala Glu
    850                 855                 860                 
Gly Ser Asn Pro Pro Lys Pro Leu Lys Lys Leu Arg Phe Asp Ile Glu
865                 870                 875                 880 
Gly Ser Asp Glu Ala Asp Gly Ser Lys His Leu Pro Gly Glu Ser Lys
                885                 890                 895     
Phe Gln Gln Lys Leu Ala Glu Met Thr Ser Thr Arg Thr Arg Met Gln
            900                 905                 910         
Lys Gln Lys Met Asn Asp Ser Met Asp Thr Ser Asn Lys Glu Glu Lys
        915                 920                 925             


<210> 50
<211> 248
<212> PRT
<213> Homo sapiens

<400> 50
Ala Pro Ser Arg Lys Phe Phe Val Gly Gly Asn Trp Lys Met Asn Gly
 1               5                  10                  15      
Arg Lys Lys Asn Leu Gly Glu Leu Ile Thr Thr Leu Asn Ala Ala Lys
            20                  25                  30          
Val Pro Ala Asp Thr Glu Val Val Cys Ala Pro Pro Thr Ala Tyr Ile
        35                  40                  45              
Asp Phe Ala Arg Gln Lys Leu Asp Pro Lys Ile Ala Val Ala Ala Gln
    50                  55                  60                  
Asn Cys Tyr Lys Val Thr Asn Gly Ala Phe Thr Gly Glu Ile Ser Pro
65                  70                  75                  80  
Gly Met Ile Lys Asp Cys Gly Ala Thr Trp Val Val Leu Gly His Ser
                85                  90                  95      
Glu Arg Arg His Val Phe Gly Glu Ser Asp Glu Leu Ile Gly Gln Lys
            100                 105                 110         
Val Ala His Ala Leu Ser Glu Gly Leu Gly Val Ile Ala Cys Ile Gly
        115                 120                 125             
Glu Lys Leu Asp Glu Arg Glu Ala Gly Ile Thr Glu Lys Val Val Phe
    130                 135                 140                 
Glu Gln Thr Lys Val Ile Ala Asp Asn Val Lys Asp Trp Ser Lys Val
145                 150                 155                 160 
Val Leu Ala Tyr Glu Pro Val Trp Ala Ile Gly Thr Gly Lys Thr Ala
                165                 170                 175     
Thr Pro Gln Gln Ala Gln Glu Val His Glu Lys Leu Arg Gly Trp Leu
            180                 185                 190         
Lys Ser Asn Val Ser Asp Ala Val Ala Gln Ser Thr Arg Ile Ile Tyr
        195                 200                 205             
Gly Gly Ser Val Thr Gly Ala Thr Cys Lys Glu Leu Ala Ser Gln Pro
    210                 215                 220                 
Asp Val Asp Gly Phe Leu Val Gly Gly Ala Ser Leu Lys Pro Glu Phe
225                 230                 235                 240 
Val Asp Ile Ile Asn Ala Lys Gln
                245             


<210> 51
<211> 284
<212> PRT
<213> Homo sapiens

<400> 51
Met Asp Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu
 1               5                  10                  15      
Asn Ala Ile Asp Arg Ala Glu Gln Ala Glu Ala Asp Lys Lys Gln Ala
            20                  25                  30          
Glu Asp Arg Cys Lys Gln Leu Glu Glu Glu Gln Gln Ala Leu Gln Lys
        35                  40                  45              
Lys Leu Lys Gly Thr Glu Asp Glu Val Glu Lys Tyr Ser Glu Ser Val
    50                  55                  60                  
Lys Glu Ala Gln Glu Lys Leu Glu Gln Ala Glu Lys Lys Ala Thr Asp
65                  70                  75                  80  
Ala Glu Ala Asp Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu
                85                  90                  95      
Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys
            100                 105                 110         
Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys
        115                 120                 125             
Val Ile Glu Asn Arg Ala Met Lys Asp Glu Glu Lys Met Glu Leu Gln
    130                 135                 140                 
Glu Met Gln Leu Lys Glu Ala Lys His Ile Ala Glu Asp Ser Asp Arg
145                 150                 155                 160 
Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Leu Glu Gly Glu Leu
                165                 170                 175     
Glu Arg Ser Glu Glu Arg Ala Glu Val Ala Glu Ser Lys Cys Gly Asp
            180                 185                 190         
Leu Glu Glu Glu Leu Lys Ile Val Thr Asn Asn Leu Lys Ser Leu Glu
        195                 200                 205             
Ala Gln Ala Asp Lys Tyr Ser Thr Lys Glu Asp Lys Tyr Glu Glu Glu
    210                 215                 220                 
Ile Lys Leu Leu Glu Glu Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu
225                 230                 235                 240 
Phe Ala Glu Arg Ser Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu
                245                 250                 255     
Glu Asp Glu Val Tyr Ala Gln Lys Met Lys Tyr Lys Ala Ile Ser Glu
            260                 265                 270         
Glu Leu Asp Asn Ala Leu Asn Asp Ile Thr Ser Leu
        275                 280                 


<210> 52
<211> 210
<212> PRT
<213> Homo sapiens

<400> 52
Met Ala Asp Gly Ser Ser Asp Ala Ala Arg Glu Pro Arg Pro Ala Pro
 1               5                  10                  15      
Ala Pro Ile Arg Arg Arg Ser Ser Asn Tyr Arg Ala Tyr Ala Thr Glu
            20                  25                  30          
Pro His Ala Lys Lys Lys Ser Lys Ile Ser Ala Ser Arg Lys Leu Gln
        35                  40                  45              
Leu Lys Thr Leu Leu Leu Gln Ile Ala Lys Gln Glu Leu Glu Arg Glu
    50                  55                  60                  
Ala Glu Glu Arg Arg Gly Glu Lys Gly Arg Ala Leu Ser Thr Arg Cys
65                  70                  75                  80  
Gln Pro Leu Glu Leu Ala Gly Leu Gly Phe Ala Glu Leu Gln Asp Leu
                85                  90                  95      
Cys Arg Gln Leu His Ala Arg Val Asp Lys Val Asp Glu Glu Arg Tyr
            100                 105                 110         
Asp Ile Glu Ala Lys Val Thr Lys Asn Ile Thr Glu Ile Ala Asp Leu
        115                 120                 125             
Thr Gln Lys Ile Phe Asp Leu Arg Gly Lys Phe Lys Arg Pro Thr Leu
    130                 135                 140                 
Arg Arg Val Arg Ile Ser Ala Asp Ala Met Met Gln Ala Leu Leu Gly
145                 150                 155                 160 
Ala Arg Ala Lys Glu Ser Leu Asp Leu Arg Ala His Leu Lys Gln Val
                165                 170                 175     
Lys Lys Glu Asp Thr Glu Lys Glu Asn Arg Glu Val Gly Asp Trp Arg
            180                 185                 190         
Lys Asn Ile Asp Ala Leu Ser Gly Met Glu Gly Arg Lys Lys Lys Phe
        195                 200                 205             
Glu Ser
    210 


<210> 53
<211> 543
<212> PRT
<213> Homo sapiens

<400> 53
Asp Phe Thr Gln Glu Glu Trp Gly Gln Leu Asp Pro Thr Gln Arg Ile
 1               5                  10                  15      
Leu Tyr Arg Asp Val Met Leu Glu Thr Phe Gly Tyr Leu Leu Ser Ile
            20                  25                  30          
Gly Pro Glu Leu Pro Lys Pro Glu Val Ile Ser Gln Leu Glu Gln Gly
        35                  40                  45              
Thr Glu Leu Trp Val Ala Glu Arg Gly Thr Thr Gln Gly Cys His Pro
    50                  55                  60                  
Ala Trp Glu Pro Arg Ser Glu Ser Gln Ala Ser Arg Lys Glu Glu Gly
65                  70                  75                  80  
Leu Pro Glu Glu Glu Pro Ser His Val Thr Gly Arg Glu Gly Phe Pro
                85                  90                  95      
Thr Asp Ala Pro Tyr Pro Thr Thr Leu Gly Lys Asp Arg Glu Cys Gln
            100                 105                 110         
Ser Gln Ser Leu Ala Leu Lys Glu Gln Asn Asn Leu Lys Gln Leu Glu
        115                 120                 125             
Phe Gly Leu Lys Glu Ala Pro Val Gln Asp Gln Ala Tyr Lys Thr Leu
    130                 135                 140                 
Arg Leu Arg Glu Asn Cys Val Leu Ser Ser Ser Pro Asn Pro Phe Pro
145                 150                 155                 160 
Glu Ile Ser Arg Gly Glu Tyr Leu Tyr Thr Tyr Asp Ser Gln Ile Thr
                165                 170                 175     
Asp Ser Glu His Asn Ser Ser Leu Val Ser Gln Gln Thr Gly Ser Pro
            180                 185                 190         
Gly Lys Gln Pro Gly Glu Asn Ser Asp Cys His Arg Asp Ser Ser Gln
        195                 200                 205             
Ala Ile Pro Ile Thr Glu Leu Thr Lys Ser Gln Val Gln Asp Lys Pro
    210                 215                 220                 
Tyr Lys Cys Thr Asp Cys Gly Lys Ser Phe Asn His Asn Ala His Leu
225                 230                 235                 240 
Thr Val His Lys Arg Ile His Thr Gly Glu Arg Pro Tyr Met Cys Lys
                245                 250                 255     
Glu Cys Gly Lys Ala Phe Ser Gln Asn Ser Ser Leu Val Gln His Glu
            260                 265                 270         
Arg Ile His Thr Gly Asp Lys Pro Tyr Lys Cys Ala Glu Cys Gly Lys
        275                 280                 285             
Ser Phe Cys His Ser Thr His Leu Thr Val His Arg Arg Ile His Thr
    290                 295                 300                 
Gly Glu Lys Pro Tyr Glu Cys Gln Asp Cys Gly Arg Ala Phe Asn Gln
305                 310                 315                 320 
Asn Ser Ser Leu Gly Arg His Lys Arg Thr His Thr Gly Glu Lys Pro
                325                 330                 335     
Tyr Thr Cys Ser Val Cys Gly Lys Ser Phe Ser Arg Thr Thr Cys Leu
            340                 345                 350         
Phe Leu His Leu Arg Thr His Thr Glu Glu Arg Pro Tyr Glu Cys Asn
        355                 360                 365             
His Cys Gly Lys Gly Phe Arg His Ser Ser Ser Leu Ala Gln His Gln
    370                 375                 380                 
Arg Lys His Ala Gly Glu Lys Pro Phe Glu Cys Arg Gln Arg Leu Ile
385                 390                 395                 400 
Phe Glu Gln Thr Pro Ala Leu Thr Lys His Glu Trp Thr Glu Ala Leu
                405                 410                 415     
Gly Cys Asp Pro Pro Leu Ser Gln Asp Glu Arg Thr His Arg Ser Asp
            420                 425                 430         
Arg Pro Phe Lys Cys Asn Gln Cys Gly Lys Cys Phe Ile Gln Ser Ser
        435                 440                 445             
His Leu Ile Arg His Gln Ile Thr His Thr Arg Glu Glu Gln Pro His
    450                 455                 460                 
Gly Arg Ser Arg Arg Arg Glu Gln Ser Ser Ser Arg Asn Ser His Leu
465                 470                 475                 480 
Val Gln His Gln His Pro Asn Ser Arg Lys Ser Ser Ala Gly Gly Arg
                485                 490                 495     
Lys Ala Gly Gln Pro Glu Ser Arg Ala Leu Ala Leu Phe Asp Ile Gln
            500                 505                 510         
Lys Ile Met Gln Glu Lys Asn Pro Val His Val Ile Gly Val Glu Glu
        515                 520                 525             
Pro Ser Val Gly Ala Ser Met Leu Phe Asp Ile Arg Glu Ser Thr
    530                 535                 540             


<210> 54
<211> 418
<212> PRT
<213> Homo sapiens

<400> 54
Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys
 1               5                  10                  15      
Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala
            20                  25                  30          
Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn
        35                  40                  45              
Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln
    50                  55                  60                  
Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser
65                  70                  75                  80  
Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr
                85                  90                  95      
His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro
            100                 105                 110         
Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn
        115                 120                 125             
Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu
    130                 135                 140                 
Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys
145                 150                 155                 160 
Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu
                165                 170                 175     
Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys
            180                 185                 190         
Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu
        195                 200                 205             
Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val
    210                 215                 220                 
Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Ala Thr Thr Val
225                 230                 235                 240 
Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys
                245                 250                 255     
Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala
            260                 265                 270         
Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu
        275                 280                 285             
Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp
    290                 295                 300                 
Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr
305                 310                 315                 320 
Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe
                325                 330                 335     
Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys
            340                 345                 350         
Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Lys Lys Gly
        355                 360                 365             
Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile
    370                 375                 380                 
Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu
385                 390                 395                 400 
Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr
                405                 410                 415     
Gln Lys
        


<210> 55
<211> 604
<212> PRT
<213> Homo sapiens

<400> 55
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala
 1               5                  10                  15      
Tyr Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala
            20                  25                  30          
His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu
        35                  40                  45              
Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val
    50                  55                  60                  
Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp
65                  70                  75                  80  
Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp
                85                  90                  95      
Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala
            100                 105                 110         
Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln
        115                 120                 125             
His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val
    130                 135                 140                 
Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys
145                 150                 155                 160 
Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro
                165                 170                 175     
Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys
            180                 185                 190         
Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu
        195                 200                 205             
Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys
    210                 215                 220                 
Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val
225                 230                 235                 240 
Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser
                245                 250                 255     
Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly
            260                 265                 270         
Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile
        275                 280                 285             
Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu
    290                 295                 300                 
Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp
305                 310                 315                 320 
Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser
                325                 330                 335     
Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly
            340                 345                 350         
Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val
        355                 360                 365             
Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys
    370                 375                 380                 
Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu
385                 390                 395                 400 
Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys
                405                 410                 415     
Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu
            420                 425                 430         
Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val
        435                 440                 445             
Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His
    450                 455                 460                 
Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val
465                 470                 475                 480 
Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg
                485                 490                 495     
Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe
            500                 505                 510         
Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala
        515                 520                 525             
Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu
    530                 535                 540                 
Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys
545                 550                 555                 560 
Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala
                565                 570                 575     
Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe
            580                 585                 590         
Ala Glu Glu Pro Thr Met Arg Ile Arg Glu Arg Lys
        595                 600                 


<210> 56
<211> 517
<212> PRT
<213> Homo sapiens

<400> 56
Met Leu Arg Ala Ala Ala Arg Phe Gly Pro Arg Leu Gly Arg Arg Leu
 1               5                  10                  15      
Leu Ser Ala Ala Ala Thr Gln Ala Val Pro Ala Pro Asn Gln Gln Pro
            20                  25                  30          
Glu Val Phe Cys Asn Gln Ile Phe Ile Asn Asn Glu Trp His Asp Ala
        35                  40                  45              
Val Ser Arg Lys Thr Phe Pro Thr Val Asn Pro Ser Thr Gly Glu Val
    50                  55                  60                  
Ile Cys Gln Val Ala Glu Gly Asp Lys Glu Asp Val Asp Lys Ala Val
65                  70                  75                  80  
Lys Ala Ala Arg Ala Ala Phe Gln Leu Gly Ser Pro Trp Arg Arg Met
                85                  90                  95      
Asp Ala Ser His Arg Gly Arg Leu Leu Asn Arg Leu Ala Asp Leu Ile
            100                 105                 110         
Glu Arg Asp Arg Thr Tyr Leu Ala Ala Leu Glu Thr Leu Asp Asn Gly
        115                 120                 125             
Lys Pro Tyr Val Ile Ser Tyr Leu Val Asp Leu Asp Met Val Leu Lys
    130                 135                 140                 
Cys Leu Arg Tyr Tyr Ala Gly Trp Ala Asp Lys Tyr His Gly Lys Thr
145                 150                 155                 160 
Ile Pro Ile Asp Gly Asp Phe Phe Ser Tyr Thr Arg His Glu Pro Val
                165                 170                 175     
Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Leu Met Gln
            180                 185                 190         
Ala Trp Lys Leu Gly Pro Ala Leu Ala Thr Gly Asn Val Val Val Met
        195                 200                 205             
Lys Val Ala Glu Gln Thr Pro Leu Thr Ala Leu Tyr Val Ala Asn Leu
    210                 215                 220                 
Ile Lys Glu Ala Gly Phe Pro Pro Gly Val Val Asn Ile Val Pro Gly
225                 230                 235                 240 
Phe Gly Pro Thr Ala Gly Ala Ala Ile Ala Ser His Glu Asp Val Asp
                245                 250                 255     
Lys Val Ala Phe Thr Gly Ser Thr Glu Ile Gly Arg Val Ile Gln Val
            260                 265                 270         
Ala Ala Gly Ser Ser Asn Leu Lys Arg Val Thr Leu Glu Leu Gly Gly
        275                 280                 285             
Lys Ser Pro Asn Ile Ile Met Ser Asp Ala Asp Met Asp Trp Ala Val
    290                 295                 300                 
Glu Gln Ala His Phe Ala Leu Phe Phe Asn Gln Gly Gln Cys Cys Cys
305                 310                 315                 320 
Ala Gly Ser Arg Thr Phe Val Gln Glu Asp Ile Tyr Asp Glu Phe Val
                325                 330                 335     
Glu Arg Ser Val Ala Arg Ala Lys Ser Arg Val Val Gly Asn Pro Phe
            340                 345                 350         
Asp Ser Lys Thr Glu Gln Gly Pro Gln Val Asp Glu Thr Gln Phe Lys
        355                 360                 365             
Lys Ile Leu Gly Tyr Ile Asn Thr Gly Lys Gln Gln Gly Ala Lys Leu
    370                 375                 380                 
Leu Cys Gly Gly Gly Ile Ala Ala Asp Arg Gly Tyr Phe Ile Gln Pro
385                 390                 395                 400 
Thr Val Phe Gly Asp Val Gln Asp Gly Met Thr Ile Ala Lys Glu Glu
                405                 410                 415     
Ile Phe Gly Pro Val Met Gln Ile Leu Lys Phe Lys Thr Ile Glu Glu
            420                 425                 430         
Val Val Gly Arg Ala Asn Asn Ser Thr Tyr Gly Leu Ala Ala Ala Val
        435                 440                 445             
Phe Thr Lys Asp Leu Asp Lys Ala Asn Tyr Leu Ser Gln Ala Leu Gln
    450                 455                 460                 
Ala Gly Thr Val Trp Val Asn Cys Tyr Asp Val Phe Gly Ala Gln Ser
465                 470                 475                 480 
Pro Phe Gly Gly Tyr Lys Met Ser Gly Ser Gly Arg Glu Leu Gly Glu
                485                 490                 495     
Tyr Gly Leu Gln Ala Tyr Thr Glu Val Lys Thr Val Thr Val Lys Val
            500                 505                 510         
Pro Gln Lys Asn Ser
        515         


<210> 57
<211> 920
<212> PRT
<213> Homo sapiens

<400> 57
Glu Ala Asn Gln Gln Gln Gln Phe Asn Arg Asn Val Glu Asp Ile Glu
 1               5                  10                  15      
Leu Trp Leu Tyr Glu Val Glu Gly His Leu Ala Ser Asp Asp Tyr Gly
            20                  25                  30          
Lys Asp Leu Thr Asn Val Gln Asn Leu Gln Lys Lys His Ala Leu Leu
        35                  40                  45              
Glu Ala Asp Val Ala Ala His Gln Asp Arg Ile Asp Gly Val Thr Ile
    50                  55                  60                  
Gln Ala Arg Gln Phe Gln Asp Ala Gly His Phe Asp Ala Glu Asn Ile
65                  70                  75                  80  
Lys Lys Lys Gln Glu Ala Leu Val Ala Arg Tyr Glu Ala Leu Lys Glu
                85                  90                  95      
Pro Met Val Ala Arg Lys Gln Lys Leu Ala Asp Ser Leu Arg Leu Gln
            100                 105                 110         
Gln Leu Phe Arg Asp Val Glu Asp Glu Glu Thr Trp Ile Arg Glu Lys
        115                 120                 125             
Glu Pro Ile Ala Ala Ser Thr Asn Arg Gly Lys Asp Leu Ile Gly Val
    130                 135                 140                 
Gln Asn Leu Leu Lys Lys His Gln Ala Leu Gln Ala Glu Ile Ala Gly
145                 150                 155                 160 
His Glu Pro Arg Ile Lys Ala Val Thr Gln Lys Gly Asn Ala Met Val
                165                 170                 175     
Glu Glu Gly His Phe Ala Ala Glu Asp Val Lys Ala Lys Leu His Glu
            180                 185                 190         
Leu Asn Gln Lys Trp Glu Ala Leu Lys Ala Lys Ala Ser Gln Arg Arg
        195                 200                 205             
Gln Asp Leu Glu Asp Ser Leu Gln Ala Gln Gln Tyr Phe Ala Asp Ala
    210                 215                 220                 
Asn Glu Ala Glu Ser Trp Met Arg Glu Lys Glu Pro Ile Val Gly Ser
225                 230                 235                 240 
Thr Asp Tyr Gly Lys Asp Glu Asp Ser Ala Glu Ala Leu Leu Lys Lys
                245                 250                 255     
His Glu Ala Leu Met Ser Asp Leu Ser Ala Tyr Gly Ser Ser Ile Gln
            260                 265                 270         
Ala Leu Arg Glu Gln Ala Gln Ser Cys Arg Gln Gln Val Ala Pro Thr
        275                 280                 285             
Asp Asp Glu Thr Gly Lys Glu Leu Val Leu Ala Leu Tyr Asp Tyr Gln
    290                 295                 300                 
Glu Lys Ser Pro Arg Glu Val Thr Met Lys Lys Gly Asp Ile Leu Thr
305                 310                 315                 320 
Leu Leu Asn Ser Thr Asn Lys Asp Trp Trp Lys Val Glu Val Asn Asp
                325                 330                 335     
Arg Gln Gly Phe Val Pro Ala Ala Tyr Val Lys Lys Leu Asp Pro Ala
            340                 345                 350         
Gln Ser Ala Ser Arg Glu Asn Leu Leu Glu Glu Gln Gly Ser Ile Ala
        355                 360                 365             
Leu Arg Gln Glu Gln Ile Asp Asn Gln Thr Arg Ile Thr Lys Glu Ala
    370                 375                 380                 
Gly Ser Val Ser Leu Arg Met Lys Gln Val Glu Glu Leu Tyr His Ser
385                 390                 395                 400 
Leu Leu Glu Leu Gly Glu Lys Arg Lys Gly Met Leu Glu Lys Ser Cys
                405                 410                 415     
Lys Lys Phe Met Leu Phe Arg Glu Ala Asn Glu Leu Gln Gln Trp Ile
            420                 425                 430         
Asn Glu Lys Glu Ala Ala Leu Thr Ser Glu Glu Val Gly Ala Asp Leu
        435                 440                 445             
Glu Gln Val Glu Val Leu Gln Lys Lys Phe Asp Asp Phe Gln Lys Asp
    450                 455                 460                 
Leu Lys Ala Asn Glu Ser Arg Leu Lys Asp Ile Asn Lys Val Ala Glu
465                 470                 475                 480 
Asp Leu Glu Ser Glu Gly Leu Met Ala Glu Glu Val Gln Ala Val Gln
                485                 490                 495     
Gln Gln Glu Val Tyr Gly Met Met Pro Arg Asp Glu Thr Asp Ser Lys
            500                 505                 510         
Thr Ala Ser Pro Trp Lys Ser Ala Arg Leu Met Val His Thr Val Ala
        515                 520                 525             
Thr Phe Asn Ser Ile Lys Glu Leu Asn Glu Arg Trp Arg Ser Leu Gln
    530                 535                 540                 
Gln Leu Ala Glu Glu Arg Ser Gln Leu Leu Gly Ser Ala His Glu Val
545                 550                 555                 560 
Gln Arg Phe His Arg Asp Ala Asp Glu Thr Lys Glu Trp Ile Glu Glu
                565                 570                 575     
Lys Asn Gln Ala Leu Asn Thr Asp Asn Tyr Gly His Asp Leu Ala Ser
            580                 585                 590         
Val Gln Ala Leu Gln Arg Lys His Glu Gly Phe Glu Arg Asp Leu Ala
        595                 600                 605             
Ala Leu Gly Asp Lys Val Asn Ser Leu Gly Glu Thr Ala Glu Arg Leu
    610                 615                 620                 
Thr Gln Ser His Pro Glu Ser Ala Glu Asp Leu Gln Glu Lys Cys Thr
625                 630                 635                 640 
Glu Leu Asn Gln Ala Trp Ser Ser Leu Gly Lys Arg Ala Asp Gln Arg
                645                 650                 655     
Lys Ala Lys Leu Gly Asp Ser His Asp Leu Gln Arg Phe Leu Ser Asp
            660                 665                 670         
Phe Arg Asp Leu Met Ser Trp Ile Asn Gly Ile Arg Gly Leu Val Ser
        675                 680                 685             
Ser Asp Glu Leu Ala Lys Asp Val Thr Gly Ala Glu Ala Leu Leu Glu
    690                 695                 700                 
Arg His Gln Glu His Arg Thr Glu Ile Asp Ala Arg Ala Gly Thr Phe
705                 710                 715                 720 
Gln Ala Phe Glu Gln Phe Gly Gln Gln Leu Leu Ala His Gly His Tyr
                725                 730                 735     
Ala Ser Pro Glu Ile Lys Gln Lys Leu Asp Ile Leu Asp Gln Glu Arg
            740                 745                 750         
Ala Asp Leu Glu Lys Ala Trp Val Gln Arg Arg Met Met Leu Asp Gln
        755                 760                 765             
Cys Leu Glu Leu Gln Leu Phe His Arg Asp Cys Glu Gln Ala Glu Asn
    770                 775                 780                 
Trp Met Ala Ala Arg Glu Ala Phe Leu Asn Thr Glu Asp Lys Gly Asp
785                 790                 795                 800 
Ser Leu Asp Ser Val Glu Ala Leu Ile Lys Lys His Glu Asp Phe Asp
                805                 810                 815     
Lys Ala Ile Asn Val Gln Glu Glu Lys Ile Ala Ala Leu Gln Ala Phe
            820                 825                 830         
Ala Asp Gln Leu Ile Ala Ala Gly His Tyr Ala Lys Gly Asp Ile Ser
        835                 840                 845             
Ser Arg Arg Asn Glu Val Leu Asp Arg Trp Arg Arg Leu Lys Ala Gln
    850                 855                 860                 
Met Ile Glu Lys Arg Ser Lys Leu Gly Glu Ser Gln Thr Leu Gln Gln
865                 870                 875                 880 
Phe Ser Arg Asp Val Asp Glu Ile Glu Ala Trp Ile Ser Glu Lys Leu
                885                 890                 895     
Gln Thr Ala Ser Asp Glu Ser Tyr Lys Asp Pro Thr Asn Ile Gln Ser
            900                 905                 910         
Lys His Gln Lys His Gln Ala Arg
        915                 920 


<210> 58
<211> 836
<212> PRT
<213> Homo sapiens

<400> 58
Asn Lys Phe Ile Ile Pro Gly Leu Lys Leu Asn Asp Leu Asn Ser Val
 1               5                  10                  15      
Leu Val Met Pro Thr Phe His Val Pro Phe Thr Asp Leu Gln Val Pro
            20                  25                  30          
Ser Cys Lys Leu Asp Phe Arg Glu Ile Gln Ile Tyr Lys Lys Leu Arg
        35                  40                  45              
Thr Ser Ser Phe Ala Leu Asn Leu Pro Thr Leu Pro Glu Val Lys Phe
    50                  55                  60                  
Pro Glu Val Asp Val Leu Thr Lys Tyr Ser Gln Pro Glu Asp Ser Leu
65                  70                  75                  80  
Ile Pro Phe Phe Glu Ile Thr Val Pro Glu Ser Gln Leu Thr Val Ser
                85                  90                  95      
Gln Phe Thr Leu Pro Lys Ser Val Ser Asp Gly Ile Ala Ala Leu Asp
            100                 105                 110         
Leu Asn Ala Val Ala Asn Lys Ile Ala Asp Phe Glu Leu Pro Thr Ile
        115                 120                 125             
Ile Val Pro Glu Gln Thr Ile Glu Ile Pro Ser Ile Lys Phe Ser Val
    130                 135                 140                 
Pro Ala Gly Ile Ala Ile Pro Ser Phe Gln Ala Leu Thr Ala Arg Phe
145                 150                 155                 160 
Glu Val Asp Ser Pro Val Tyr Asn Ala Thr Trp Ser Ala Ser Leu Lys
                165                 170                 175     
Asn Lys Ala Asp Tyr Val Glu Thr Val Leu Asp Ser Thr Cys Ser Ser
            180                 185                 190         
Thr Val Gln Phe Leu Glu Tyr Glu Leu Asn Val Leu Gly Thr His Lys
        195                 200                 205             
Ile Glu Asp Gly Thr Leu Ala Ser Lys Thr Lys Gly Thr Phe Ala His
    210                 215                 220                 
Arg Asp Phe Ser Ala Glu Tyr Glu Glu Asp Gly Lys Tyr Glu Gly Leu
225                 230                 235                 240 
Gln Glu Trp Glu Gly Lys Ala His Leu Asn Ile Lys Ser Pro Ala Ser
                245                 250                 255     
Thr Asp Leu His Leu Arg Tyr Gln Lys Asp Lys Lys Gly Ile Ser Thr
            260                 265                 270         
Ser Ala Pro Ser Pro Ala Val Gly Thr Val Gly Met Asp Met Asp Glu
        275                 280                 285             
Asp Asp Asp Phe Ser Lys Trp Asn Phe Tyr Tyr Ser Pro Gln Ser Ser
    290                 295                 300                 
Pro Asp Lys Lys Leu Thr Ile Phe Lys Thr Glu Leu Arg Val Arg Glu
305                 310                 315                 320 
Ser Asp Glu Glu Thr Gln Ile Lys Val Asn Trp Glu Glu Glu Ala Ala
                325                 330                 335     
Ser Gly Leu Leu Thr Ser Leu Lys Asp Asn Val Pro Lys Ala Thr Gly
            340                 345                 350         
Val Leu Tyr Asp Tyr Val Asn Lys Tyr His Trp Glu His Thr Gly Leu
        355                 360                 365             
Thr Leu Arg Glu Val Ser Ser Lys Leu Arg Arg Asn Leu Gln Asp His
    370                 375                 380                 
Ala Glu Trp Val Tyr Gln Gly Ala Ile Arg Glu Ile Asp Asp Ile Asp
385                 390                 395                 400 
Glu Arg Phe Gln Lys Gly Ala Ser Gly Thr Thr Gly Thr Tyr Gln Glu
                405                 410                 415     
Trp Lys Asp Lys Ala Gln Asn Leu Tyr Gln Glu Leu Leu Thr Gln Glu
            420                 425                 430         
Gly Gln Ala Ser Phe Gln Gly Leu Lys Asp Asn Val Phe Asp Gly Leu
        435                 440                 445             
Val Arg Val Thr Gln Glu Phe His Met Lys Val Lys His Leu Ile Asp
    450                 455                 460                 
Ser Leu Ile Asp Phe Leu Asn Phe Pro Arg Phe Gln Phe Pro Gly Lys
465                 470                 475                 480 
Pro Gly Ile Tyr Thr Arg Glu Glu Leu Cys Thr Met Phe Ile Arg Glu
                485                 490                 495     
Val Gly Thr Val Leu Ser Gln Val Tyr Ser Lys Val His Asn Gly Ser
            500                 505                 510         
Glu Ile Leu Phe Ser Tyr Phe Gln Asp Leu Val Ile Thr Leu Pro Phe
        515                 520                 525             
Glu Leu Arg Lys His Lys Leu Ile Asp Val Ile Ser Met Tyr Arg Glu
    530                 535                 540                 
Leu Leu Lys Asp Leu Ser Lys Glu Ala Gln Glu Val Phe Lys Ala Ile
545                 550                 555                 560 
Gln Ser Leu Lys Thr Thr Glu Val Leu Arg Asn Leu Gln Asp Leu Leu
                565                 570                 575     
Gln Phe Ile Phe Gln Leu Ile Glu Asp Asn Ile Lys Gln Leu Lys Glu
            580                 585                 590         
Met Lys Phe Thr Tyr Leu Ile Asn Tyr Ile Gln Asp Glu Ile Asn Thr
        595                 600                 605             
Ile Phe Asn Asp Tyr Ile Pro Tyr Val Phe Lys Leu Leu Lys Glu Asn
    610                 615                 620                 
Leu Cys Leu Asn Leu His Lys Phe Asn Glu Phe Ile Gln Asn Glu Leu
625                 630                 635                 640 
Gln Glu Ala Ser Gln Glu Leu Gln Gln Ile His Gln Tyr Ile Met Ala
                645                 650                 655     
Leu Arg Glu Glu Tyr Phe Asp Pro Ser Ile Val Gly Trp Thr Val Lys
            660                 665                 670         
Tyr Tyr Glu Leu Glu Glu Lys Ile Val Ser Leu Ile Lys Asn Leu Leu
        675                 680                 685             
Val Ala Leu Lys Asp Phe His Ser Glu Tyr Ile Val Ser Ala Ser Asn
    690                 695                 700                 
Phe Thr Ser Gln Leu Ser Ser Gln Val Glu Gln Phe Leu His Arg Asn
705                 710                 715                 720 
Ile Gln Glu Tyr Leu Ser Ile Leu Thr Asp Pro Asp Gly Lys Gly Lys
                725                 730                 735     
Glu Lys Ile Ala Glu Leu Ser Ala Thr Ala Gln Glu Ile Ile Lys Ser
            740                 745                 750         
Gln Ala Ile Ala Thr Lys Lys Ile Ile Ser Asp Tyr His Gln Gln Phe
        755                 760                 765             
Arg Tyr Lys Leu Gln Asp Phe Ser Asp Gln Leu Ser Asp Tyr Tyr Glu
    770                 775                 780                 
Lys Phe Ile Ala Glu Ser Lys Arg Leu Ile Asp Leu Ser Ile Gln Asn
785                 790                 795                 800 
Tyr His Thr Phe Leu Ile Tyr Ile Thr Glu Leu Leu Lys Lys Leu Gln
                805                 810                 815     
Ser Thr Thr Val Met Asn Pro Tyr Met Lys Leu Ala Pro Gly Glu Leu
            820                 825                 830         
Thr Ile Ile Leu
        835     


<210> 59
<211> 402
<212> PRT
<213> Homo sapiens

<400> 59
Met Ala Pro Trp Pro His Glu Asn Ser Ser Leu Ala Pro Trp Pro Asp
 1               5                  10                  15      
Leu Pro Thr Leu Ala Pro Asn Thr Ala Asn Thr Ser Gly Leu Pro Gly
            20                  25                  30          
Val Pro Trp Glu Ala Ala Leu Ala Gly Ala Leu Leu Ala Leu Ala Val
        35                  40                  45              
Leu Ala Thr Val Gly Gly Asn Leu Leu Val Ile Val Ala Ile Ala Trp
    50                  55                  60                  
Thr Pro Arg Leu Gln Thr Met Thr Asn Val Phe Val Thr Ser Leu Ala
65                  70                  75                  80  
Ala Ala Asp Leu Val Met Gly Leu Leu Val Val Pro Pro Ala Ala Thr
                85                  90                  95      
Leu Ala Leu Thr Gly His Trp Pro Leu Gly Ala Thr Gly Cys Glu Leu
            100                 105                 110         
Trp Thr Ser Val Asp Val Leu Cys Val Thr Ala Ser Ile Glu Thr Leu
        115                 120                 125             
Cys Ala Leu Ala Val Asp Arg Tyr Leu Ala Val Thr Asn Pro Leu Arg
    130                 135                 140                 
Tyr Gly Ala Leu Val Thr Lys Arg Cys Ala Arg Thr Ala Val Val Leu
145                 150                 155                 160 
Val Trp Val Val Ser Ala Ala Val Ser Phe Ala Pro Ile Met Ser Gln
                165                 170                 175     
Trp Trp Arg Val Gly Ala Asp Ala Glu Ala Gln Arg Cys His Ser Asn
            180                 185                 190         
Pro Arg Cys Cys Ala Phe Ala Ser Asn Met Pro Tyr Val Leu Leu Ser
        195                 200                 205             
Ser Ser Val Ser Phe Tyr Leu Pro Leu Leu Val Met Leu Phe Val Tyr
    210                 215                 220                 
Ala Arg Val Phe Val Val Ala Thr Arg Gln Leu Arg Leu Leu Arg Gly
225                 230                 235                 240 
Glu Leu Gly Arg Phe Pro Pro Glu Glu Ser Pro Pro Ala Pro Ser Arg
                245                 250                 255     
Ser Leu Ala Pro Ala Pro Val Gly Thr Cys Ala Pro Pro Glu Gly Val
            260                 265                 270         
Pro Ala Cys Gly Arg Arg Pro Ala Arg Leu Leu Pro Leu Arg Glu His
        275                 280                 285             
Arg Ala Leu Cys Thr Leu Gly Leu Ile Met Gly Thr Phe Thr Leu Cys
    290                 295                 300                 
Trp Leu Pro Phe Phe Leu Ala Asn Val Leu Arg Ala Leu Gly Gly Pro
305                 310                 315                 320 
Ser Leu Val Pro Gly Pro Ala Phe Leu Ala Leu Asn Trp Leu Gly Tyr
                325                 330                 335     
Ala Asn Ser Ala Phe Asn Pro Leu Ile Tyr Cys Arg Ser Pro Asp Phe
            340                 345                 350         
Arg Ser Ala Phe Arg Arg Leu Leu Cys Arg Cys Gly Arg Arg Leu Pro
        355                 360                 365             
Pro Glu Pro Cys Ala Ala Ala Arg Pro Ala Leu Phe Pro Ser Gly Val
    370                 375                 380                 
Pro Ala Ala Arg Ser Ser Pro Ala Gln Pro Arg Leu Cys Gln Arg Leu
385                 390                 395                 400 
Asp Gly
        


<210> 60
<211> 529
<212> PRT
<213> Homo sapiens

<400> 60
Met Leu Gly Phe Val Gly Arg Val Ala Ala Ala Pro Ala Ser Gly Ala
 1               5                  10                  15      
Leu Arg Arg Leu Thr Pro Ser Ala Ser Leu Pro Pro Ala Gln Leu Leu
            20                  25                  30          
Leu Arg Ala Val Arg Arg Arg Phe His Pro Val Arg Asp Tyr Ala Ala
        35                  40                  45              
Gln Thr Ser Pro Ser Pro Lys Ala Gly Ala Ala Thr Gly Arg Ile Val
    50                  55                  60                  
Ala Val Ile Gly Ala Val Val Asp Val Gln Phe Asp Glu Gly Leu Pro
65                  70                  75                  80  
Pro Ile Leu Asn Ala Leu Glu Val Gln Gly Arg Glu Thr Arg Leu Val
                85                  90                  95      
Leu Glu Val Ala Gln His Leu Gly Glu Ser Thr Val Arg Thr Ile Ala
            100                 105                 110         
Met Asp Gly Thr Glu Gly Leu Val Arg Gly Gln Lys Val Leu Asp Ser
        115                 120                 125             
Gly Asp Gln Leu Lys Ile Pro Val Gly Pro Glu Thr Leu Gly Arg Ile
    130                 135                 140                 
Met Asn Val Ile Gly Glu Pro Ile Asp Glu Arg Gly Pro Ile Lys Thr
145                 150                 155                 160 
Lys Gln Phe Ala Pro Ile His Ala Glu Ala Pro Glu Phe Met Glu Met
                165                 170                 175     
Ser Val Glu Gln Glu Ile Leu Val Thr Gly Ile Lys Val Val Asp Leu
            180                 185                 190         
Leu Ala Pro Tyr Ala Lys Gly Gly Lys Ile Gly Leu Phe Gly Gly Ala
        195                 200                 205             
Gly Val Gly Lys Thr Val Leu Ile Met Glu Leu Ile Asn Asn Val Ala
    210                 215                 220                 
Lys Ala His Gly Gly Tyr Ser Val Phe Ala Gly Val Gly Glu Arg Thr
225                 230                 235                 240 
Arg Glu Gly Asn Asp Leu Tyr His Glu Met Ile Glu Ser Gly Val Ile
                245                 250                 255     
Asn Leu Lys Asp Ala Thr Ser Lys Val Ala Leu Val Tyr Gly Gln Met
            260                 265                 270         
Asn Gln Pro Pro Gly Ala Arg Ala Arg Val Ala Leu Thr Gly Leu Thr
        275                 280                 285             
Val Ala Glu Tyr Phe Arg Asp Gln Glu Gly Gln Asp Val Leu Leu Phe
    290                 295                 300                 
Ile Asp Asn Ile Phe Arg Phe Thr Gln Ala Gly Ser Glu Val Ser Ala
305                 310                 315                 320 
Leu Leu Gly Arg Ile Pro Ser Ala Val Gly Tyr Gln Pro Thr Leu Ala
                325                 330                 335     
Thr Asp Met Gly Thr Met Gln Glu Arg Ile Thr Thr Thr Lys Lys Gly
            340                 345                 350         
Ser Ile Thr Ser Val Gln Ala Ile Tyr Val Pro Ala Asp Asp Leu Thr
        355                 360                 365             
Asp Pro Ala Pro Ala Thr Thr Phe Ala Asp Leu Asp Ala Thr Thr Val
    370                 375                 380                 
Leu Ser Arg Ala Ile Ala Glu Leu Gly Ile Tyr Pro Ala Val Asp Pro
385                 390                 395                 400 
Leu Asp Ser Thr Ser Arg Ile Met Asp Pro Asn Ile Val Gly Ser Glu
                405                 410                 415     
His Tyr Asp Val Ala Arg Gly Val Gln Lys Ile Leu Gln Asp Tyr Lys
            420                 425                 430         
Ser Leu His Asp Ile Ile Ala Ile Leu Gly Met Asp Glu Leu Ser Glu
        435                 440                 445             
Glu Asp Lys Leu Thr Val Ser Arg Ala Arg Lys Ile Gln Arg Phe Leu
    450                 455                 460                 
Ser Gln Pro Phe Gln Val Ala Glu Val Phe Thr Gly His Met Gly Lys
465                 470                 475                 480 
Leu Val Pro Leu Lys Glu Thr Ile Lys Gly Phe Gln Gln Ile Leu Ala
                485                 490                 495     
Gly Glu Tyr Asp His Leu Pro Glu Gln Ala Phe Tyr Met Val Gly Pro
            500                 505                 510         
Ile Glu Glu Ala Val Ala Lys Ala Asp Lys Leu Ala Glu Glu His Ser
        515                 520                 525             
Ser
    


<210> 61
<211> 457
<212> PRT
<213> Homo sapiens

<400> 61
Met Arg Ser Ala Ala Val Leu Ala Leu Leu Leu Cys Ala Gly Gln Val
 1               5                  10                  15      
Thr Ala Leu Pro Val Asn Ser Pro Met Asn Lys Gly Asp Thr Glu Val
            20                  25                  30          
Met Lys Cys Ile Val Glu Val Ile Tyr Asp Thr Leu Ser Lys Pro Ser
        35                  40                  45              
Pro Met Pro Val Ser Lys Glu Cys Phe Glu Thr Leu Arg Gly Asp Glu
    50                  55                  60                  
Arg Ile Leu Ser Ile Leu Arg His Gln Asn Leu Leu Lys Glu Leu Gln
65                  70                  75                  80  
Asp Leu Ala Leu Gln Gly Arg Lys Glu Arg Ala His Gln Gln Lys Lys
                85                  90                  95      
His Ser Gly Phe Glu Asp Glu Leu Ser Glu Val Leu Glu Asn Gln Ser
            100                 105                 110         
Ser Gln Ala Glu Leu Lys Gln Ala Val Glu Glu Pro Ser Ser Lys Asp
        115                 120                 125             
Val Met Glu Lys Arg Glu Asp Ser Lys Glu Ala Glu Lys Ser Gly Glu
    130                 135                 140                 
Ala Thr Asp Gly Ala Arg Pro Gln Ala Leu Pro Glu Pro Met Gln Glu
145                 150                 155                 160 
Ser Lys Ala Glu Gly Asn Lys Gln Ala Pro Gly Glu Glu Glu Glu Glu
                165                 170                 175     
Glu Glu Glu Ala Thr Asn Thr His Pro Pro Ala Ser Leu Pro Ser Gln
            180                 185                 190         
Lys Tyr Pro Gly Pro Gln Ala Lys Gly Asp Ser Glu Gly Leu Ser Gln
        195                 200                 205             
Gly Leu Val Asp Arg Glu Lys Gly Leu Ser Val Glu Pro Gly Trp Gln
    210                 215                 220                 
Ala Lys Arg Glu Glu Glu Glu Glu Glu Glu Glu Glu Ala Glu Ala Gly
225                 230                 235                 240 
Glu Glu Ala Val Pro Glu Glu Glu Gly Pro Thr Val Val Leu Asn Pro
                245                 250                 255     
His Pro Ser Leu Gly Tyr Lys Glu Ile Arg Lys Gly Glu Ser Arg Ser
            260                 265                 270         
Glu Ala Leu Ala Val Asp Gly Ala Gly Lys Pro Gly Ala Glu Glu Ala
        275                 280                 285             
Gln Asp Pro Glu Gly Lys Gly Glu Gln Glu His Ser Gln Gln Lys Glu
    290                 295                 300                 
Glu Glu Glu Glu Met Ala Val Val Pro Gln Gly Leu Phe Arg Gly Gly
305                 310                 315                 320 
Lys Ser Gly Glu Leu Glu Gln Glu Glu Glu Arg Leu Ser Lys Glu Trp
                325                 330                 335     
Glu Asp Thr Asn Arg Trp Ser Lys Met Asp Gln Leu Ala Lys Glu Leu
            340                 345                 350         
Thr Ala Glu Lys Arg Leu Glu Gly Gln Glu Glu Glu Glu Asp Asn Arg
        355                 360                 365             
Asp Arg Ser Met Arg Leu Ser Phe Arg Ala Arg Gly Tyr Gly Phe Arg
    370                 375                 380                 
Gly Pro Gly Pro Gln Leu Arg Arg Gly Ser Arg Pro Asn Ser Trp Glu
385                 390                 395                 400 
Asp Ser Leu Glu Ala Gly Leu Pro Leu Gln Val Arg Gly Tyr Pro Gln
                405                 410                 415     
Glu Lys Lys Glu Glu Glu Gly Ser Ala Asn Arg Arg Pro Glu Asp Gln
            420                 425                 430         
Glu Leu Glu Ser Leu Ser Ala Ile Glu Ala Glu Leu Glu Lys Val Ala
        435                 440                 445             
His Gln Leu Gln Ala Leu Arg Arg Gly
    450                 455         


<210> 62
<211> 227
<212> PRT
<213> Homo sapiens

<400> 62
Arg Gly Leu Leu Ser Ser Leu Asp His Thr Ser Ile Arg Arg Gly Phe
 1               5                  10                  15      
Gln Val Tyr Lys Gln Val Cys Ala Ser Cys His Ser Met Asp Phe Val
            20                  25                  30          
Ala Tyr Arg His Leu Val Gly Val Cys Tyr Thr Glu Asp Glu Ala Lys
        35                  40                  45              
Glu Leu Ala Ala Glu Val Glu Val Gln Asp Gly Pro Asn Glu Asp Gly
    50                  55                  60                  
Glu Met Phe Met Arg Pro Gly Lys Leu Phe Asp Tyr Phe Pro Lys Pro
65                  70                  75                  80  
Tyr Pro Asn Ser Glu Ala Ala Arg Ala Ala Asn Asn Gly Ala Leu Pro
                85                  90                  95      
Pro Asp Leu Ser Tyr Ile Val Arg Ala Arg His Gly Gly Glu Asp Tyr
            100                 105                 110         
Val Phe Ser Leu Leu Thr Gly Tyr Cys Glu Pro Pro Thr Gly Val Ser
        115                 120                 125             
Leu Arg Glu Gly Leu Tyr Phe Asn Pro Tyr Phe Pro Gly Gln Ala Ile
    130                 135                 140                 
Ala Met Ala Pro Pro Ile Tyr Thr Asp Val Leu Glu Phe Asp Asp Gly
145                 150                 155                 160 
Thr Pro Ala Thr Met Ser Gln Ile Ala Lys Asp Val Cys Thr Phe Leu
                165                 170                 175     
Arg Trp Ala Ser Glu Pro Glu His Asp His Arg Lys Arg Met Gly Leu
            180                 185                 190         
Lys Met Leu Met Met Met Ala Leu Leu Val Pro Leu Val Tyr Thr Ile
        195                 200                 205             
Lys Arg His Lys Trp Ser Val Leu Lys Ser Arg Lys Leu Ala Tyr Arg
    210                 215                 220                 
Pro Pro Lys
225         


<210> 63
<211> 49
<212> PRT
<213> Homo sapiens

<400> 63
Ile Glu Thr Gln Ser Thr Ser Ser Glu Glu Leu Val Pro Ser Pro Pro
 1               5                  10                  15      
Ser Pro Leu Pro Pro Pro Arg Val Tyr Lys Pro Cys Phe Val Cys Gln
            20                  25                  30          
Asp Lys Ser Ser Gly Tyr His Tyr Gly Val Ser Ala Cys Glu Gly Cys
        35                  40                  45              
Lys
    


<210> 64
<211> 151
<212> PRT
<213> Homo sapiens

<400> 64
Met Cys Asp Phe Thr Glu Asp Gln Thr Ala Glu Phe Lys Glu Ala Phe
 1               5                  10                  15      
Gln Leu Phe Asp Arg Thr Gly Asp Gly Lys Ile Leu Tyr Ser Gln Cys
            20                  25                  30          
Gly Asp Val Met Arg Ala Leu Gly Gln Asn Pro Thr Asp Ala Glu Val
        35                  40                  45              
Leu Lys Val Leu Gly Asn Pro Lys Ser Asp Glu Met Asn Val Lys Val
    50                  55                  60                  
Leu Asp Phe Glu His Phe Leu Pro Met Leu Gln Thr Val Ala Lys Asn
65                  70                  75                  80  
Lys Asp Gln Gly Thr Tyr Glu Asp Tyr Val Glu Gly Leu Arg Val Phe
                85                  90                  95      
Asp Lys Glu Gly Asn Gly Thr Val Met Gly Ala Glu Ile Arg His Val
            100                 105                 110         
Leu Val Thr Leu Gly Glu Lys Met Thr Glu Glu Glu Val Glu Met Leu
        115                 120                 125             
Val Ala Gly His Glu Asp Ser Asn Gly Cys Ile Asn Tyr Glu Ala Phe
    130                 135                 140                 
Val Arg His Ile Leu Ser Gly
145                 150     


<210> 65
<211> 2491
<212> PRT
<213> Homo sapiens

<400> 65
Met Gly Ala Ala Ala Gly Arg Ser Pro His Leu Gly Pro Ala Pro Ala
 1               5                  10                  15      
Arg Arg Pro Gln Arg Ser Leu Leu Leu Leu Gln Leu Leu Leu Leu Val
            20                  25                  30          
Ala Ala Pro Gly Ser Thr Gln Ala Gln Ala Ala Pro Phe Pro Glu Leu
        35                  40                  45              
Cys Ser Tyr Thr Trp Glu Ala Val Asp Thr Lys Asn Asn Val Leu Tyr
    50                  55                  60                  
Lys Ile Asn Ile Cys Gly Ser Val Asp Ile Val Gln Cys Gly Pro Ser
65                  70                  75                  80  
Ser Ala Val Cys Met His Asp Leu Lys Thr Arg Thr Tyr His Ser Val
                85                  90                  95      
Gly Asp Ser Val Leu Arg Ser Ala Thr Arg Ser Leu Leu Glu Phe Asn
            100                 105                 110         
Thr Thr Val Ser Cys Asp Gln Gln Gly Thr Asn His Arg Val Gln Ser
        115                 120                 125             
Ser Ile Ala Phe Leu Cys Gly Lys Thr Leu Gly Thr Pro Glu Phe Val
    130                 135                 140                 
Thr Ala Thr Glu Cys Val His Tyr Phe Glu Trp Arg Thr Thr Ala Ala
145                 150                 155                 160 
Cys Lys Lys Asp Ile Phe Lys Ala Asn Lys Glu Val Pro Cys Tyr Val
                165                 170                 175     
Phe Asp Glu Glu Leu Arg Lys His Asp Leu Asn Pro Leu Ile Lys Leu
            180                 185                 190         
Ser Gly Ala Tyr Leu Val Asp Asp Ser Asp Pro Asp Thr Ser Leu Phe
        195                 200                 205             
Ile Asn Val Cys Arg Asp Ile Asp Thr Leu Arg Asp Pro Gly Ser Gln
    210                 215                 220                 
Leu Arg Ala Cys Pro Pro Gly Thr Ala Ala Cys Leu Val Arg Gly His
225                 230                 235                 240 
Gln Ala Phe Asp Val Gly Gln Pro Arg Asp Gly Leu Lys Val Val Arg
                245                 250                 255     
Lys Asp Arg Leu Val Leu Ser Tyr Val Arg Glu Glu Ala Gly Lys Leu
            260                 265                 270         
Asp Phe Cys Asp Gly His Ser Pro Ala Val Thr Ile Thr Phe Val Cys
        275                 280                 285             
Pro Ser Glu Arg Arg Glu Gly Thr Ile Pro Lys Leu Thr Ala Lys Ser
    290                 295                 300                 
Asn Cys Arg Tyr Glu Ile Glu Trp Ile Thr Glu Tyr Ala Cys His Arg
305                 310                 315                 320 
Asp Tyr Leu Glu Ser Lys Thr Cys Ser Leu Ser Gly Glu Gln Gln Asp
                325                 330                 335     
Val Ser Ile Asp Leu Thr Pro Leu Ala Gln Ser Gly Gly Ser Ser Tyr
            340                 345                 350         
Ile Ser Asp Gly Lys Glu Tyr Leu Phe Tyr Leu Asn Val Cys Gly Glu
        355                 360                 365             
Thr Glu Ile Gln Phe Cys Asn Lys Lys Gln Ala Ala Val Cys Gln Val
    370                 375                 380                 
Lys Lys Ser Asp Thr Ser Gln Val Lys Ala Ala Gly Arg Tyr His Asn
385                 390                 395                 400 
Gln Thr Leu Arg Tyr Ser Asp Gly Asp Leu Thr Leu Ile Tyr Phe Gly
                405                 410                 415     
Gly Asp Glu Cys Ser Ser Gly Phe Gln Arg Met Ser Val Ile Asn Phe
            420                 425                 430         
Glu Cys Asn Lys Thr Ala Gly Asn Asp Gly Lys Gly Thr Pro Val Phe
        435                 440                 445             
Thr Gly Glu Val Asp Cys Thr Tyr Phe Phe Thr Trp Asp Thr Glu Tyr
    450                 455                 460                 
Ala Cys Val Lys Glu Lys Glu Asp Leu Leu Cys Gly Ala Thr Asp Gly
465                 470                 475                 480 
Lys Lys Arg Tyr Asp Leu Ser Ala Leu Val Arg His Ala Glu Pro Glu
                485                 490                 495     
Gln Asn Trp Glu Ala Val Asp Gly Ser Gln Thr Glu Thr Lys Lys Lys
            500                 505                 510         
His Phe Phe Ile Asn Ile Cys His Arg Val Leu Gln Glu Gly Lys Ala
        515                 520                 525             
Arg Gly Cys Pro Glu Asp Ala Ala Val Cys Ala Val Asp Lys Asn Gly
    530                 535                 540                 
Ser Lys Asn Leu Gly Lys Phe Ile Ser Ser Pro Met Lys Glu Lys Gly
545                 550                 555                 560 
Asn Ile Gln Leu Ser Tyr Ser Asp Gly Asp Asp Cys Gly His Gly Lys
                565                 570                 575     
Lys Ile Lys Thr Asn Ile Thr Leu Val Cys Lys Pro Gly Asp Leu Glu
            580                 585                 590         
Ser Ala Pro Val Leu Arg Thr Ser Gly Glu Gly Gly Cys Phe Tyr Glu
        595                 600                 605             
Phe Glu Trp His Thr Ala Ala Ala Cys Val Leu Ser Lys Thr Glu Gly
    610                 615                 620                 
Glu Asn Cys Thr Val Phe Asp Ser Gln Ala Gly Phe Ser Phe Asp Leu
625                 630                 635                 640 
Ser Pro Leu Thr Lys Lys Asn Gly Ala Tyr Lys Val Glu Thr Lys Lys
                645                 650                 655     
Tyr Asp Phe Tyr Ile Asn Val Cys Gly Pro Val Ser Val Ser Pro Cys
            660                 665                 670         
Gln Pro Asp Ser Gly Ala Cys Gln Val Ala Lys Ser Asp Glu Lys Thr
        675                 680                 685             
Trp Asn Leu Gly Leu Ser Asn Ala Lys Leu Ser Tyr Tyr Asp Gly Met
    690                 695                 700                 
Ile Gln Leu Asn Tyr Arg Gly Gly Thr Pro Tyr Asn Asn Glu Arg His
705                 710                 715                 720 
Thr Pro Arg Ala Thr Leu Ile Thr Phe Leu Cys Asp Arg Asp Ala Gly
                725                 730                 735     
Val Gly Phe Pro Glu Tyr Gln Glu Glu Asp Asn Ser Thr Tyr Asn Phe
            740                 745                 750         
Arg Trp Tyr Thr Ser Tyr Ala Cys Pro Glu Glu Pro Leu Glu Cys Val
        755                 760                 765             
Val Thr Asp Pro Ser Thr Leu Glu Gln Tyr Asp Leu Ser Ser Leu Ala
    770                 775                 780                 
Lys Ser Glu Gly Gly Leu Gly Gly Asn Trp Tyr Ala Met Asp Asn Ser
785                 790                 795                 800 
Gly Glu His Val Thr Trp Arg Lys Tyr Tyr Ile Asn Val Cys Arg Pro
                805                 810                 815     
Leu Asn Pro Val Pro Gly Cys Asn Arg Tyr Ala Ser Ala Cys Gln Met
            820                 825                 830         
Lys Tyr Glu Lys Asp Gln Gly Ser Phe Thr Glu Val Ala Ser Ile Ser
        835                 840                 845             
Asn Leu Gly Met Ala Lys Thr Gly Pro Val Val Glu Asp Ser Gly Ser
    850                 855                 860                 
Leu Leu Leu Glu Tyr Val Asn Gly Ser Ala Cys Thr Thr Ser Asp Gly
865                 870                 875                 880 
Arg Gln Thr Thr Tyr Thr Thr Arg Ile His Leu Val Cys Ser Arg Gly
                885                 890                 895     
Arg Leu Asn Ser His Pro Ile Phe Ser Leu Asn Trp Glu Cys Val Val
            900                 905                 910         
Ser Phe Leu Trp Asn Thr Glu Ala Ala Cys Pro Ile Gln Thr Thr Thr
        915                 920                 925             
Asp Thr Asp Gln Ala Cys Ser Ile Arg Asp Pro Asn Ser Gly Phe Val
    930                 935                 940                 
Phe Asn Leu Asn Pro Leu Asn Ser Ser Gln Gly Tyr Asn Val Ser Gly
945                 950                 955                 960 
Ile Gly Lys Ile Phe Met Phe Asn Val Cys Gly Thr Met Pro Val Cys
                965                 970                 975     
Gly Thr Ile Leu Gly Lys Pro Ala Ser Gly Cys Glu Ala Glu Thr Gln
            980                 985                 990         
Thr Glu Glu Leu Lys Asn Trp Lys Pro Ala Arg Pro Val Gly Ile Glu
        995                 1000                1005            
Lys Ser Leu Gln Leu Ser Thr Glu Gly Phe Ile Thr Leu Thr Tyr Lys
    1010                1015                1020                
Gly Pro Leu Ser Ala Lys Gly Thr Ala Asp Ala Phe Ile Val Arg Phe
1025                1030                1035                1040
Val Cys Asn Asp Asp Val Tyr Ser Gly Pro Leu Lys Phe Leu His Gln
                1045                1050                1055    
Asp Ile Asp Ser Gly Gln Gly Ile Arg Asn Thr Tyr Phe Glu Phe Glu
            1060                1065                1070        
Thr Ala Leu Ala Cys Val Pro Ser Pro Val Asp Cys Gln Val Thr Asp
        1075                1080                1085            
Leu Ala Gly Asn Glu Tyr Asp Leu Thr Gly Leu Ser Thr Val Arg Lys
    1090                1095                1100                
Pro Trp Thr Ala Val Asp Thr Ser Val Asp Gly Arg Lys Arg Thr Phe
1105                1110                1115                1120
Tyr Leu Ser Val Cys Asn Pro Leu Pro Tyr Ile Pro Gly Cys Gln Gly
                1125                1130                1135    
Ser Ala Val Gly Ser Cys Leu Val Ser Glu Gly Asn Ser Trp Asn Leu
            1140                1145                1150        
Gly Val Val Gln Met Ser Pro Gln Ala Ala Ala Asn Gly Ser Leu Ser
        1155                1160                1165            
Ile Met Tyr Val Asn Gly Asp Lys Cys Gly Asn Gln Arg Phe Ser Thr
    1170                1175                1180                
Arg Ile Thr Phe Glu Cys Ala Gln Ile Ser Gly Ser Pro Ala Phe Gln
1185                1190                1195                1200
Leu Gln Asp Gly Cys Glu Tyr Val Phe Ile Trp Arg Thr Val Glu Ala
                1205                1210                1215    
Cys Pro Val Val Arg Val Glu Gly Asp Asn Cys Glu Val Lys Asp Pro
            1220                1225                1230        
Arg His Gly Asn Leu Tyr Asp Leu Lys Pro Leu Gly Leu Asn Asp Thr
        1235                1240                1245            
Ile Val Ser Ala Gly Glu Tyr Thr Tyr Tyr Phe Arg Val Cys Gly Lys
    1250                1255                1260                
Leu Ser Ser Asp Val Cys Pro Thr Ser Asp Lys Ser Lys Val Val Ser
1265                1270                1275                1280
Ser Cys Gln Glu Lys Arg Glu Pro Gln Gly Phe His Lys Val Ala Gly
                1285                1290                1295    
Leu Leu Thr Gln Lys Leu Thr Tyr Glu Asn Gly Leu Leu Lys Met Asn
            1300                1305                1310        
Phe Thr Gly Gly Asp Thr Cys His Lys Val Tyr Gln Arg Ser Thr Ala
        1315                1320                1325            
Ile Phe Phe Tyr Cys Asp Arg Gly Thr Gln Arg Pro Val Phe Leu Lys
    1330                1335                1340                
Glu Thr Ser Asp Cys Ser Tyr Leu Phe Glu Trp Arg Thr Gln Tyr Ala
1345                1350                1355                1360
Cys Pro Pro Phe Asp Leu Thr Glu Cys Ser Phe Lys Asp Gly Ala Gly
                1365                1370                1375    
Asn Ser Phe Asp Leu Ser Ser Leu Ser Arg Tyr Ser Asp Asn Trp Glu
            1380                1385                1390        
Ala Ile Thr Gly Thr Gly Asp Pro Glu His Tyr Leu Ile Asn Val Cys
        1395                1400                1405            
Lys Ser Leu Ala Pro Gln Ala Gly Thr Glu Pro Cys Pro Pro Glu Ala
    1410                1415                1420                
Ala Ala Cys Leu Leu Gly Gly Ser Lys Pro Val Asn Leu Gly Arg Val
1425                1430                1435                1440
Arg Asp Gly Pro Gln Trp Arg Asp Gly Ile Ile Val Leu Lys Tyr Val
                1445                1450                1455    
Asp Gly Asp Leu Cys Pro Asp Gly Ile Arg Lys Lys Ser Thr Thr Ile
            1460                1465                1470        
Arg Phe Thr Cys Ser Glu Ser Gln Val Asn Ser Arg Pro Met Phe Ile
        1475                1480                1485            
Asn Ala Val Glu Asp Cys Glu Tyr Thr Phe Ala Trp Pro Thr Ala Thr
    1490                1495                1500                
Ala Cys Pro Met Lys Ser Asn Glu His Asp Asp Cys Gln Val Thr Asn
1505                1510                1515                1520
Pro Ser Thr Gly His Leu Phe Asp Leu Ser Ser Leu Ser Gly Arg Ala
                1525                1530                1535    
Gly Phe Thr Ala Ala Tyr Ser Glu Lys Gly Leu Val Tyr Met Ser Ile
            1540                1545                1550        
Cys Gly Glu Asn Glu Asn Cys Pro Pro Gly Val Gly Ala Cys Phe Gly
        1555                1560                1565            
Gln Thr Arg Ile Ser Val Gly Lys Ala Asn Lys Arg Leu Arg Tyr Val
    1570                1575                1580                
Asp Gln Val Leu Gln Leu Val Tyr Lys Asp Gly Ser Pro Cys Pro Ser
1585                1590                1595                1600
Lys Ser Gly Leu Ser Tyr Lys Ser Val Ile Ser Phe Val Cys Arg Pro
                1605                1610                1615    
Glu Ala Gly Pro Thr Asn Arg Pro Met Leu Ile Ser Leu Asp Lys Gln
            1620                1625                1630        
Thr Cys Thr Leu Phe Phe Ser Trp His Thr Pro Leu Ala Cys Glu Gln
        1635                1640                1645            
Ala Thr Glu Cys Ser Val Arg Asn Gly Ser Ser Ile Val Asp Leu Ser
    1650                1655                1660                
Pro Leu Ile His Arg Thr Gly Gly Tyr Glu Ala Tyr Asp Glu Ser Glu
1665                1670                1675                1680
Asp Asp Ala Ser Asp Thr Asn Pro Asp Phe Tyr Ile Asn Ile Cys Gln
                1685                1690                1695    
Pro Leu Asn Pro Met His Gly Val Pro Cys Pro Ala Gly Ala Ala Val
            1700                1705                1710        
Cys Lys Val Pro Ile Asp Gly Pro Pro Ile Asp Ile Gly Arg Val Ala
        1715                1720                1725            
Gly Pro Pro Ile Leu Asn Pro Ile Ala Asn Glu Ile Tyr Leu Asn Phe
    1730                1735                1740                
Glu Ser Ser Thr Pro Cys Leu Ala Asp Lys His Phe Asn Tyr Thr Ser
1745                1750                1755                1760
Leu Ile Ala Phe His Cys Lys Arg Gly Val Ser Met Gly Thr Pro Lys
                1765                1770                1775    
Leu Leu Arg Thr Ser Glu Cys Asp Phe Val Phe Glu Trp Glu Thr Pro
            1780                1785                1790        
Val Val Cys Pro Asp Glu Val Arg Met Asp Gly Cys Thr Leu Thr Asp
        1795                1800                1805            
Glu Gln Leu Leu Tyr Ser Phe Asn Leu Ser Ser Leu Ser Thr Ser Thr
    1810                1815                1820                
Phe Lys Val Thr Arg Asp Ser Arg Thr Tyr Ser Val Gly Val Cys Thr
1825                1830                1835                1840
Phe Ala Val Gly Pro Glu Gln Gly Gly Cys Lys Asp Gly Gly Val Cys
                1845                1850                1855    
Leu Leu Ser Gly Thr Lys Gly Ala Ser Phe Gly Arg Leu Gln Ser Met
            1860                1865                1870        
Lys Leu Asp Tyr Arg His Gln Asp Glu Ala Val Val Leu Ser Tyr Val
        1875                1880                1885            
Asn Gly Asp Arg Cys Pro Pro Glu Thr Asp Asp Gly Val Pro Cys Val
    1890                1895                1900                
Phe Pro Phe Ile Phe Asn Gly Lys Ser Tyr Glu Glu Cys Ile Ile Glu
1905                1910                1915                1920
Ser Arg Ala Lys Leu Trp Cys Ser Thr Thr Ala Asp Tyr Asp Arg Asp
                1925                1930                1935    
His Glu Trp Gly Phe Cys Arg His Ser Asn Ser Tyr Arg Thr Ser Ser
            1940                1945                1950        
Ile Ile Phe Lys Cys Asp Glu Asp Glu Asp Ile Gly Arg Pro Gln Val
        1955                1960                1965            
Phe Ser Glu Val Arg Gly Cys Asp Val Thr Phe Glu Trp Lys Thr Lys
    1970                1975                1980                
Val Val Cys Pro Pro Lys Lys Leu Glu Cys Lys Phe Val Gln Lys His
1985                1990                1995                2000
Lys Thr Tyr Asp Leu Arg Leu Leu Ser Ser Leu Thr Gly Ser Trp Ser
                2005                2010                2015    
Leu Val His Asn Gly Val Ser Tyr Tyr Met Asn Leu Cys Gln Lys Ile
            2020                2025                2030        
Tyr Lys Gly Pro Leu Gly Cys Ser Glu Arg Ala Ser Ile Cys Arg Arg
        2035                2040                2045            
Thr Thr Thr Gly Asp Val Gln Val Leu Gly Leu Val His Thr Gln Lys
    2050                2055                2060                
Leu Gly Val Ile Gly Asp Lys Val Val Val Met Tyr Ser Lys Gly Tyr
2065                2070                2075                2080
Pro Cys Gly Gly Asn Lys Thr Ala Ser Ser Val Ile Glu Leu Thr Cys
                2085                2090                2095    
Thr Lys Thr Val Gly Arg Pro Ala Phe Lys Arg Phe Asp Ile Asp Ser
            2100                2105                2110        
Cys Thr Tyr Tyr Phe Ser Trp Asp Ser Arg Ala Ala Cys Ala Val Lys
        2115                2120                2125            
Pro Gln Glu Val Gln Met Val Asn Gly Thr Ile Thr Asn Pro Ile Asn
    2130                2135                2140                
Gly Lys Ser Phe Ser Leu Gly Asp Ile Tyr Phe Asn Leu Phe Arg Glu
2145                2150                2155                2160
Ser Gly Asp Met Arg Thr Asn Gly Asp Asn Tyr Leu Tyr Glu Ile Leu
                2165                2170                2175    
Leu Ser Ser Ile Thr Ser Ser Arg Asn Pro Ala Cys Ser Gly Ala Asn
            2180                2185                2190        
Ile Cys Gln Val Lys Pro Asn Asp Gln His Phe Ser Arg Lys Val Gly
        2195                2200                2205            
Thr Ser Asp Lys Thr Lys Tyr Tyr Leu Gln Asp Gly Asp Leu Asp Val
    2210                2215                2220                
Val Phe Ala Ser Ser Ser Lys Cys Gly Lys Asp Lys Thr Lys Ser Val
2225                2230                2235                2240
Ser Ser Thr Ile Phe Phe His Cys Asp Pro Leu Val Glu Asp Gly Ile
                2245                2250                2255    
Pro Glu Phe Ser His Glu Thr Ala Asp Cys Gln Tyr Leu Phe Ser Trp
            2260                2265                2270        
Tyr Thr Ser Ala Val Cys Pro Leu Gly Val Gly Phe Asp Ser Glu Asn
        2275                2280                2285            
Pro Gly Asp Asp Gly Gln Met His Lys Gly Leu Ser Glu Arg Ser Gln
    2290                2295                2300                
Ala Val Gly Ala Val Leu Ser Leu Leu Leu Val Ala Leu Thr Cys Cys
2305                2310                2315                2320
Leu Leu Ala Leu Leu Leu Tyr Lys Lys Lys Arg Arg Glu Thr Met Ile
                2325                2330                2335    
Ser Lys Leu Thr Ser Cys Cys Arg Arg Ser Ser Asn Val Ser Tyr Lys
            2340                2345                2350        
Tyr Ser Lys Val Asn Lys Glu Glu Glu Thr Asp Glu Asn Glu Thr Glu
        2355                2360                2365            
Trp Leu Met Glu Glu Ile Gln Leu Pro Pro Pro Arg Gln Gly Lys Glu
    2370                2375                2380                
Gly Gln Glu Asn Gly His Ile Thr Thr Lys Ser Val Lys Ala Leu Ser
2385                2390                2395                2400
Ser Leu His Gly Asp Asp Gln Asp Ser Thr Asp Glu Val Leu Thr Ile
                2405                2410                2415    
Pro Glu Val Lys Val His Ser Gly Arg Gly Ala Gly Ala Glu Ser Ser
            2420                2425                2430        
His Pro Val Arg Asn Ala Gln Ser Asn Ala Leu Gln Glu Arg Glu Asp
        2435                2440                2445            
Asp Arg Val Gly Leu Val Arg Gly Glu Lys Ala Arg Lys Gly Lys Ser
    2450                2455                2460                
Ser Ser Ala Gln Gln Lys Thr Val Ser Ser Thr Lys Leu Val Ser Phe
2465                2470                2475                2480
His Asp Asp Ser Asp Glu Asp Leu Leu His Ile
                2485                2490    


<210> 66
<211> 869
<212> PRT
<213> Homo sapiens

<400> 66
Arg Ala Thr Pro Pro Ser Pro Ile Ser Ala Cys His Ser Thr Met Gly
 1               5                  10                  15      
Arg Lys Leu Asp Pro Thr Lys Glu Lys Arg Gly Pro Gly Arg Lys Ala
            20                  25                  30          
Arg Lys Gln Lys Gly Ala Glu Thr Glu Leu Val Arg Phe Leu Pro Ala
        35                  40                  45              
Val Ser Asp Glu Asn Ser Lys Arg Leu Ser Ser Arg Ala Arg Lys Arg
    50                  55                  60                  
Ala Ala Lys Arg Arg Leu Gly Ser Val Glu Ala Pro Lys Thr Asn Lys
65                  70                  75                  80  
Ser Pro Glu Ala Lys Pro Ser Pro Gly Lys Leu Pro Lys Gly Ile Ser
                85                  90                  95      
Ala Gly Ala Val Gln Thr Ala Gly Lys Lys Gly Pro Gln Ser Leu Phe
            100                 105                 110         
Asn Ala Pro Arg Gly Lys Lys Arg Pro Ala Pro Gly Ser Asp Glu Glu
        115                 120                 125             
Glu Glu Glu Glu Asp Ser Glu Glu Asp Gly Met Val Asn His Gly Asp
    130                 135                 140                 
Leu Trp Gly Ser Glu Asp Asp Ala Asp Thr Val Asp Asp Tyr Gly Ala
145                 150                 155                 160 
Asp Ser Asn Ser Glu Asp Glu Glu Glu Gly Glu Ala Leu Leu Pro Ile
                165                 170                 175     
Glu Arg Ala Ala Arg Lys Gln Lys Ala Arg Glu Ala Ala Ala Gly Ile
            180                 185                 190         
Gln Trp Ser Glu Glu Glu Thr Glu Asp Glu Glu Glu Glu Lys Glu Val
        195                 200                 205             
Thr Pro Glu Ser Gly Pro Pro Lys Val Glu Glu Ala Asp Gly Gly Leu
    210                 215                 220                 
Gln Ile Asn Val Asp Glu Glu Pro Phe Val Leu Pro Pro Ala Gly Glu
225                 230                 235                 240 
Met Glu Gln Asp Ala Gln Ala Pro Asp Leu Gln Arg Val His Lys Arg
                245                 250                 255     
Ile Gln Asp Ile Val Gly Ile Leu Arg Asp Phe Gly Ala Gln Arg Glu
            260                 265                 270         
Glu Gly Arg Ser Arg Ser Glu Tyr Leu Asn Arg Leu Lys Lys Asp Leu
        275                 280                 285             
Ala Ile Tyr Tyr Ser Tyr Gly Asp Phe Leu Leu Gly Lys Leu Met Asp
    290                 295                 300                 
Leu Phe Pro Leu Ser Glu Leu Val Glu Phe Leu Glu Ala Asn Glu Val
305                 310                 315                 320 
Pro Arg Pro Val Thr Leu Arg Thr Asn Thr Leu Lys Thr Arg Arg Arg
                325                 330                 335     
Asp Leu Ala Gln Ala Leu Ile Asn Arg Gly Val Asn Leu Asp Pro Leu
            340                 345                 350         
Gly Lys Trp Ser Lys Thr Gly Leu Val Val Tyr Asp Ser Ser Val Pro
        355                 360                 365             
Ile Gly Ala Thr Pro Glu Tyr Leu Ala Gly His Tyr Met Leu Gln Gly
    370                 375                 380                 
Ala Ser Ser Met Leu Pro Val Met Ala Leu Ala Pro Gln Glu His Glu
385                 390                 395                 400 
Arg Ile Leu Asp Met Cys Cys Ala Pro Gly Gly Lys Thr Ser Tyr Met
                405                 410                 415     
Ala Gln Leu Met Lys Asn Thr Gly Val Ile Leu Ala Asn Asp Ala Asn
            420                 425                 430         
Ala Glu Arg Leu Lys Ser Val Val Gly Asn Leu His Arg Leu Gly Val
        435                 440                 445             
Thr Asn Thr Ile Ile Ser His Tyr Asp Gly Arg Gln Phe Pro Lys Val
    450                 455                 460                 
Val Gly Gly Phe Asp Arg Val Leu Leu Asp Ala Pro Cys Ser Gly Thr
465                 470                 475                 480 
Gly Val Ile Ser Lys Asp Pro Ala Val Lys Thr Asn Lys Asp Glu Lys
                485                 490                 495     
Asp Ile Leu Arg Cys Ala His Leu Gln Lys Glu Leu Leu Leu Ser Ala
            500                 505                 510         
Ile Asp Ser Val Asn Ala Thr Ser Lys Thr Gly Gly Tyr Leu Val Tyr
        515                 520                 525             
Cys Thr Cys Ser Ile Thr Val Glu Glu Asn Glu Trp Val Val Asp Tyr
    530                 535                 540                 
Ala Leu Lys Lys Arg Asn Val Arg Leu Val Pro Thr Gly Leu Asp Phe
545                 550                 555                 560 
Gly Gln Glu Gly Phe Thr Arg Phe Arg Glu Arg Arg Phe His Pro Ser
                565                 570                 575     
Leu Arg Ser Thr Arg Arg Phe Tyr Pro His Thr His Asn Met Asp Gly
            580                 585                 590         
Phe Phe Ile Ala Lys Phe Lys Lys Phe Ser Asn Ser Ile Pro Gln Ser
        595                 600                 605             
Gln Thr Gly Asn Ser Glu Thr Ala Thr Pro Thr Asn Val Asp Leu Pro
    610                 615                 620                 
Gln Val Ile Pro Lys Ser Glu Asn Ser Ser Gln Pro Ala Lys Lys Ala
625                 630                 635                 640 
Lys Gly Ala Gly Lys Thr Lys Gln Gln Leu Gln Lys Gln Gln His Pro
                645                 650                 655     
Lys Lys Ala Ser Phe Gln Lys Leu Asn Gly Ile Ser Lys Gly Ala Asp
            660                 665                 670         
Ser Glu Leu Ser Thr Val Pro Ser Val Thr Lys Thr Gln Ala Ser Ser
        675                 680                 685             
Ser Phe Gln Asp Ser Ser Gln Pro Ala Gly Lys Ala Glu Gly Ile Arg
    690                 695                 700                 
Glu Pro Lys Val Thr Gly Lys Leu Lys Gln Arg Ser Pro Lys Leu Gln
705                 710                 715                 720 
Ser Ser Lys Lys Val Ala Phe Leu Arg Gln Asn Ala Pro Pro Lys Gly
                725                 730                 735     
Thr Asp Thr Gln Thr Pro Ala Val Leu Ser Pro Ser Lys Thr Gln Ala
            740                 745                 750         
Thr Leu Lys Pro Lys Asp His His Gln Pro Leu Gly Arg Ala Lys Gly
        755                 760                 765             
Val Glu Lys Gln Gln Phe Ala Glu Gln Pro Phe Glu Lys Ala Ala Phe
    770                 775                 780                 
Gln Lys Gln Asn Asp Thr Pro Lys Gly Leu Ser Leu Pro Leu Cys Leu
785                 790                 795                 800 
Pro Ser Val Pro Ala Ala Pro His Gln Gln Arg Gly Arg Asn Leu Ser
                805                 810                 815     
Pro Gly Ala Thr Ala Ser Cys Cys Tyr Leu Arg Trp Leu Lys Thr Arg
            820                 825                 830         
Arg Val Ala His Cys His Cys His Gln Val Gly Thr Leu Ala Ser Val
        835                 840                 845             
Arg Met Pro Ser Leu Leu Cys Ile Pro Met Lys Phe Asn Thr His Phe
    850                 855                 860                 
Lys Thr Ser Gly His
865                 


<210> 67
<211> 405
<212> PRT
<213> Homo sapiens

<400> 67
Thr Val Gly Asp Asp Asn Glu Glu Ala Lys Arg Lys Ser Pro Lys Lys
 1               5                  10                  15      
Lys Glu Lys Cys Glu Tyr Lys Lys Lys Ala Lys Asn Pro Lys Ser Pro
            20                  25                  30          
Lys Val Gln Ala Val Lys Asp Trp Ala Asn Gln Arg Cys Ser Ser Pro
        35                  40                  45              
Lys Gly Ser Ala Arg Asn Ser Leu Val Lys Ala Lys Arg Lys Gly Ser
    50                  55                  60                  
Val Ser Val Cys Ser Lys Glu Ser Pro Ser Ser Ser Ser Glu Ser Glu
65                  70                  75                  80  
Ser Cys Asp Glu Ser Ile Ser Asp Gly Pro Ser Lys Val Thr Leu Glu
                85                  90                  95      
Ala Arg Asn Ser Ser Glu Lys Leu Pro Thr Glu Leu Ser Lys Glu Glu
            100                 105                 110         
Pro Ser Thr Lys Asn Thr Thr Ala Asp Lys Leu Ala Ile Lys Leu Gly
        115                 120                 125             
Phe Ser Leu Thr Pro Ser Lys Gly Lys Thr Ser Gly Thr Thr Ser Ser
    130                 135                 140                 
Ser Ser Asp Ser Ser Ala Glu Ser Asp Asp Gln Cys Leu Met Ser Ser
145                 150                 155                 160 
Ser Thr Pro Glu Cys Ala Ala Gly Phe Leu Lys Thr Val Gly Leu Phe
                165                 170                 175     
Ala Gly Arg Gly Arg Pro Gly Pro Gly Leu Ser Ser Gln Thr Ala Gly
            180                 185                 190         
Ala Ala Gly Trp Arg Arg Ser Gly Ser Asn Gly Gly Gly Gln Ala Pro
        195                 200                 205             
Gly Ala Ser Pro Ser Val Ser Leu Pro Ala Ser Leu Gly Arg Gly Trp
    210                 215                 220                 
Gly Arg Glu Glu Asn Leu Phe Ser Trp Lys Gly Ala Lys Gly Arg Gly
225                 230                 235                 240 
Met Arg Gly Arg Gly Arg Gly Arg Gly His Pro Val Ser Cys Val Val
                245                 250                 255     
Asn Arg Ser Thr Asp Asn Gln Arg Gln Gln Gln Leu Asn Asp Val Val
            260                 265                 270         
Lys Asn Ser Ser Thr Ile Ile Gln Asn Pro Val Glu Thr Pro Lys Lys
        275                 280                 285             
Asp Tyr Ser Leu Leu Pro Leu Leu Ala Ala Ala Pro Gln Val Gly Glu
    290                 295                 300                 
Lys Ile Ala Phe Lys Leu Leu Glu Leu Thr Ser Ser Tyr Ser Pro Asp
305                 310                 315                 320 
Val Ser Asp Tyr Lys Glu Gly Arg Ile Leu Ser His Asn Pro Glu Thr
                325                 330                 335     
Gln Gln Val Asp Ile Glu Ile Leu Ser Ser Leu Pro Ala Leu Arg Glu
            340                 345                 350         
Pro Gly Lys Phe Asp Leu Val Tyr His Asn Glu Asn Gly Ala Glu Val
        355                 360                 365             
Val Glu Tyr Ala Val Thr Gln Glu Ser Lys Ile Thr Val Phe Trp Lys
    370                 375                 380                 
Glu Leu Ile Asp Pro Arg Leu Ile Ile Glu Ser Pro Ser Asn Thr Ser
385                 390                 395                 400 
Ser Thr Glu Pro Ala
                405 


<210> 68
<211> 321
<212> PRT
<213> Homo sapiens

<400> 68
Met Cys Ile Pro Pro Ser Tyr Ala Asp Leu Gly Lys Ala Ala Arg Asp
 1               5                  10                  15      
Ile Phe Asn Lys Gly Phe Gly Phe Gly Leu Val Lys Leu Asp Val Lys
            20                  25                  30          
Thr Lys Ser Cys Ser Gly Val Glu Phe Ser Thr Ser Gly Ser Ser Asn
        35                  40                  45              
Thr Asp Thr Gly Lys Val Thr Gly Thr Leu Glu Thr Lys Tyr Lys Trp
    50                  55                  60                  
Cys Glu Tyr Gly Leu Thr Phe Thr Glu Lys Trp Asn Thr Asp Asn Thr
65                  70                  75                  80  
Leu Gly Thr Glu Ile Ala Ile Glu Asp Gln Ile Cys Gln Gly Leu Lys
                85                  90                  95      
Leu Thr Phe Asp Thr Thr Phe Ser Pro Asn Thr Gly Lys Lys Ser Gly
            100                 105                 110         
Lys Ile Lys Ser Ser Tyr Lys Arg Glu Cys Ile Asn Leu Gly Cys Asp
        115                 120                 125             
Val Asp Phe Asp Phe Ala Gly Pro Ala Ile His Gly Ser Ala Val Phe
    130                 135                 140                 
Gly Tyr Glu Gly Trp Leu Ala Gly Tyr Gln Met Thr Phe Asp Ser Ala
145                 150                 155                 160 
Lys Ser Lys Leu Thr Arg Asn Asn Phe Ala Val Gly Tyr Arg Thr Gly
                165                 170                 175     
Asp Phe Gln Leu His Thr Asn Val Asn Asp Gly Thr Glu Phe Gly Gly
            180                 185                 190         
Ser Ile Tyr Gln Lys Val Cys Glu Asp Leu Asp Thr Ser Val Asn Leu
        195                 200                 205             
Ala Trp Thr Ser Gly Thr Asn Cys Thr Arg Phe Gly Ile Ala Ala Lys
    210                 215                 220                 
Tyr Gln Leu Asp Pro Thr Ala Ser Ile Ser Ala Lys Val Asn Asn Ser
225                 230                 235                 240 
Ser Leu Ile Gly Val Gly Tyr Thr Gln Thr Leu Arg Pro Gly Val Lys
                245                 250                 255     
Leu Thr Leu Ser Ala Leu Val Asp Gly Lys Ser Ile Asn Ala Gly Gly
            260                 265                 270         
His Lys Val Gly Ser Pro Trp Ser Trp Arg Leu Asn Pro Ala Glu Arg
        275                 280                 285             
Asn Leu Trp Glu Trp Ile Ser Glu Asp Leu Ala Leu Ile Tyr Phe His
    290                 295                 300                 
Cys Asp Gln Gln Gln Ala Phe Phe Pro Pro Glu Asp Asp Gln Asn Lys
305                 310                 315                 320 
Gly
    


<210> 69
<211> 173
<212> PRT
<213> Homo sapiens

<400> 69
Ser Cys Val Gly Phe Tyr Ser Val Phe Leu Phe Ser Leu Cys Pro Leu
 1               5                  10                  15      
Gly Asn Pro Gln Gly Pro Pro Pro Gln Gly Gly Asn Lys Pro Gln Gly
            20                  25                  30          
Pro Pro Pro Pro Pro Gly Lys Pro Gln Gly Pro Pro Pro Gln Gly Gly
        35                  40                  45              
Asn Lys Pro Gln Gly Pro Pro Pro Pro Gly Lys Pro Gln Gly Pro Pro
    50                  55                  60                  
Pro Gln Gly Gly Lys Arg Ser Arg Ser Pro Arg Ser Pro Pro Gly Lys
65                  70                  75                  80  
Pro Gln Gly Pro Pro Pro Gln Gly Gly Asn Gln Pro Gln Gly Pro Pro
                85                  90                  95      
Pro Pro Pro Gly Lys Pro Gln Gly Pro Pro Pro Gln Gly Gly Asn Lys
            100                 105                 110         
Pro Gln Gly Pro Pro Pro Pro Gly Lys Pro Gln Gly Pro Pro Pro Gln
        115                 120                 125             
Gly Asp Lys Ser Gln Ser Pro Arg Ser Pro Arg Lys Pro Gln Gly Pro
    130                 135                 140                 
Pro Pro Gln Gly Gly Asn Gln Pro Gln Gly Pro Pro Pro Pro Pro Gly
145                 150                 155                 160 
Lys Pro Gln Gly Pro Pro Gln Gln Gly Gly Asn Arg Pro
                165                 170             


<210> 70
<211> 111
<212> PRT
<213> Homo sapiens

<400> 70
Met Ala Gly Lys Gln Gly Val Ser Ala Ser Gly Lys Trp Leu Asp Gly
 1               5                  10                  15      
Ile Arg Lys Trp Tyr Tyr Asn Ala Ala Gly Phe Asn Lys Leu Gly Leu
            20                  25                  30          
Met Arg Asp Asp Thr Ile Tyr Glu Asp Glu Asp Val Lys Glu Ala Ile
        35                  40                  45              
Arg Arg Leu Pro Glu Asn Leu Tyr Asn Asp Arg Met Phe Arg Ile Lys
    50                  55                  60                  
Arg Ala Leu Asp Leu Asn Leu Lys His Gln Ile Leu Pro Lys Glu Gln
65                  70                  75                  80  
Trp Thr Lys Tyr Glu Glu Glu Asn Phe Tyr Leu Glu Pro Tyr Leu Lys
                85                  90                  95      
Glu Val Ile Arg Glu Arg Lys Glu Arg Glu Glu Trp Ala Lys Lys
            100                 105                 110     


<210> 71
<211> 111
<212> PRT
<213> Homo sapiens

<400> 71
Met Ala Gly Lys Gln Gly Val Ser Ala Ser Gly Lys Trp Leu Asp Gly
 1               5                  10                  15      
Ile Arg Lys Trp Tyr Tyr Asn Ala Ala Gly Phe Asn Lys Leu Gly Leu
            20                  25                  30          
Met Arg Asp Asp Thr Ile Tyr Glu Asp Glu Asp Val Lys Glu Ala Ile
        35                  40                  45              
Arg Arg Leu Pro Glu Asn Leu Tyr Asn Asp Arg Met Phe Arg Ile Lys
    50                  55                  60                  
Arg Ala Leu Asp Leu Asn Leu Lys His Gln Ile Leu Pro Lys Glu Gln
65                  70                  75                  80  
Trp Thr Lys Tyr Glu Glu Glu Asn Phe Tyr Leu Glu Pro Tyr Leu Lys
                85                  90                  95      
Glu Val Ile Arg Glu Arg Lys Glu Arg Glu Glu Trp Ala Lys Lys
            100                 105                 110     


<210> 72
<211> 248
<212> PRT
<213> Homo sapiens

<400> 72
Ala Pro Ser Arg Lys Phe Phe Val Gly Gly Asn Trp Lys Met Asn Gly
 1               5                  10                  15      
Arg Lys Lys Asn Leu Gly Glu Leu Ile Thr Thr Leu Asn Ala Ala Lys
            20                  25                  30          
Val Pro Ala Asp Thr Glu Val Val Cys Ala Pro Pro Thr Ala Tyr Ile
        35                  40                  45              
Asp Phe Ala Arg Gln Lys Leu Asp Pro Lys Ile Ala Val Ala Ala Gln
    50                  55                  60                  
Asn Cys Tyr Lys Val Thr Asn Gly Ala Phe Thr Gly Glu Ile Ser Pro
65                  70                  75                  80  
Gly Met Ile Lys Asp Cys Gly Ala Thr Trp Val Val Leu Gly His Ser
                85                  90                  95      
Glu Arg Arg His Val Phe Gly Glu Ser Asp Glu Leu Ile Gly Gln Lys
            100                 105                 110         
Val Ala His Ala Leu Ser Glu Gly Leu Gly Val Ile Ala Cys Ile Gly
        115                 120                 125             
Glu Lys Leu Asp Glu Arg Glu Ala Gly Ile Thr Glu Lys Val Val Phe
    130                 135                 140                 
Glu Gln Thr Lys Val Ile Ala Asp Asn Val Lys Asp Trp Ser Lys Val
145                 150                 155                 160 
Val Leu Ala Tyr Glu Pro Val Trp Ala Ile Gly Thr Gly Lys Thr Ala
                165                 170                 175     
Thr Pro Gln Gln Ala Gln Glu Val His Glu Lys Leu Arg Gly Trp Leu
            180                 185                 190         
Lys Ser Asn Val Ser Asp Ala Val Ala Gln Ser Thr Arg Ile Ile Tyr
        195                 200                 205             
Gly Gly Ser Val Thr Gly Ala Thr Cys Lys Glu Leu Ala Ser Gln Pro
    210                 215                 220                 
Asp Val Asp Gly Phe Leu Val Gly Gly Ala Ser Leu Lys Pro Glu Phe
225                 230                 235                 240 
Val Asp Ile Ile Asn Ala Lys Gln
                245             


<210> 73
<211> 102
<212> PRT
<213> Homo sapiens

<400> 73
Ser Gly Arg Gly Lys Gly Gly Lys Gly Leu Gly Lys Gly Gly Ala Lys
 1               5                  10                  15      
Arg His Arg Lys Val Leu Arg Asp Asp Ile Gln Gly Ile Thr Lys Pro
            20                  25                  30          
Ala Ile Arg Arg Leu Ala Arg Arg Gly Gly Val Lys Arg Ile Ser Gly
        35                  40                  45              
Leu Ile Tyr Glu Glu Thr Arg Gly Val Leu Lys Val Phe Leu Glu Asn
    50                  55                  60                  
Val Ile Arg Asp Ala Val Thr Tyr Thr Glu His Ala Lys Arg Lys Thr
65                  70                  75                  80  
Val Thr Ala Met Asp Val Val Tyr Ala Leu Lys Arg Gln Gly Arg Thr
                85                  90                  95      
Leu Tyr Gly Phe Gly Gly
            100         


<210> 74
<211> 153
<212> PRT
<213> Homo sapiens

<400> 74
Ala Thr Lys Ala Val Cys Val Leu Lys Gly Asx Gly Pro Val Glx Gly
 1               5                  10                  15      
Ile Ile Asx Phe Glx Glx Lys Glu Ser Asn Gly Pro Val Lys Val Trp
            20                  25                  30          
Gly Ser Ile Lys Gly Leu Thr Glu Gly Leu His Gly Phe His Val His
        35                  40                  45              
Glu Phe Gly Asp Asn Thr Ala Gly Cys Thr Ser Ala Gly Pro His Phe
    50                  55                  60                  
Asn Pro Leu Ser Arg Lys His Gly Gly Pro Lys Asp Glu Glu Arg His
65                  70                  75                  80  
Val Gly Asx Leu Gly Asx Val Thr Ala Asx Lys Asx Gly Val Ala Asx
                85                  90                  95      
Val Ser Ile Glx Asx Ser Val Ile Ser Leu Ser Gly Asx His Cys Ile
            100                 105                 110         
Ile Gly Arg Thr Leu Val Val His Glu Lys Ala Asp Asp Leu Gly Lys
        115                 120                 125             
Gly Gly Asn Glu Glu Ser Thr Lys Thr Gly Asn Ala Gly Ser Arg Leu
    130                 135                 140                 
Ala Cys Gly Val Ile Gly Ile Ala Gln
145                 150             


<210> 75
<211> 171
<212> PRT
<213> Homo sapiens

<400> 75
Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu
 1               5                  10                  15      
Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg
            20                  25                  30          
Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val
        35                  40                  45              
Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile
    50                  55                  60                  
Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys
65                  70                  75                  80  
Asp Lys Glu Ser Thr Val Gln Val Asn Tyr Arg Met Cys Gln Ser Cys
                85                  90                  95      
Val Glu Leu Asp Pro Ala Thr Val Ala Gly Ile Ile Val Thr Asp Val
            100                 105                 110         
Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly Asn
        115                 120                 125             
Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu Leu Arg
    130                 135                 140                 
Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr
145                 150                 155                 160 
Ser Asn Leu Gly Gly Asn Trp Ala Arg Asn Lys
                165                 170     


<210> 76
<211> 842
<212> PRT
<213> Homo sapiens

<400> 76
Met Ser Arg Pro Leu Ser Asp Gln Glu Lys Arg Lys Gln Ile Ser Val
 1               5                  10                  15      
Arg Gly Leu Ala Gly Val Glu Asn Val Thr Glu Leu Lys Lys Asn Phe
            20                  25                  30          
Asn Arg His Leu His Pro Thr Leu Val Lys Asp Arg Asn Val Ala Thr
        35                  40                  45              
Pro Arg Asp Tyr Tyr Phe Ala Leu Ala His Thr Val Arg Asp His Leu
    50                  55                  60                  
Val Gly Arg Trp Ile Arg Thr Gln Gln His Tyr Tyr Glu Lys Asp Pro
65                  70                  75                  80  
Lys Arg Ile Tyr Tyr Leu Ser Leu Glu Phe Tyr Met Gly Arg Thr Leu
                85                  90                  95      
Gln Asn Thr Met Val Asn Leu Ala Leu Glu Asn Ala Cys Asp Glu Ala
            100                 105                 110         
Thr Tyr Gln Leu Gly Leu Asp Met Glu Glu Leu Glu Glu Ile Glu Glu
        115                 120                 125             
Asp Ala Gly Leu Gly Asn Gly Gly Leu Gly Arg Leu Ala Ala Cys Phe
    130                 135                 140                 
Leu Asp Ser Met Ala Thr Leu Gly Leu Ala Ala Tyr Gly Tyr Gly Ile
145                 150                 155                 160 
Arg Tyr Glu Phe Gly Ile Phe Asn Gln Lys Ile Ser Gly Gly Trp Gln
                165                 170                 175     
Met Glu Glu Ala Asp Asp Trp Leu Arg Tyr Gly Asn Pro Trp Glu Lys
            180                 185                 190         
Ala Arg Pro Glu Phe Thr Leu Pro Val His Phe Tyr Gly His Val Glu
        195                 200                 205             
His Thr Ser Gln Gly Ala Lys Trp Val Asp Thr Gln Val Val Leu Ala
    210                 215                 220                 
Met Pro Tyr Asp Thr Pro Val Pro Gly Tyr Arg Asn Asn Val Val Asn
225                 230                 235                 240 
Thr Met Arg Leu Trp Ser Ala Lys Ala Pro Asn Asp Phe Asn Leu Lys
                245                 250                 255     
Asp Phe Asn Val Gly Gly Tyr Ile Gln Ala Val Leu Asp Arg Asn Leu
            260                 265                 270         
Ala Glu Asn Ile Ser Arg Val Leu Tyr Pro Asn Asp Asn Phe Phe Glu
        275                 280                 285             
Gly Lys Glu Leu Arg Leu Lys Gln Glu Tyr Phe Val Val Ala Ala Thr
    290                 295                 300                 
Leu Gln Asp Ile Ile Arg Arg Phe Lys Ser Ser Lys Pro Gly Cys Arg
305                 310                 315                 320 
Asp Pro Val Arg Thr Asn Phe Asp Ala Phe Pro Asp Lys Val Ala Ile
                325                 330                 335     
Gln Leu Asn Asp Thr His Pro Ser Leu Ala Ile Pro Glu Leu Met Arg
            340                 345                 350         
Ile Leu Val Asp Leu Glu Arg Met Asp Trp Asp Lys Ala Trp Asp Val
        355                 360                 365             
Thr Val Arg Thr Cys Ala Tyr Thr Asn His Thr Val Leu Pro Glu Ala
    370                 375                 380                 
Leu Glu Arg Trp Pro Val His Leu Leu Glu Thr Leu Leu Pro Arg His
385                 390                 395                 400 
Leu Gln Ile Ile Tyr Glu Ile Asn Gln Arg Phe Leu Asn Arg Val Ala
                405                 410                 415     
Ala Ala Phe Pro Gly Asp Val Asp Arg Leu Arg Arg Met Ser Leu Val
            420                 425                 430         
Glu Glu Gly Ala Val Lys Arg Ile Asn Met Ala His Leu Cys Ile Ala
        435                 440                 445             
Gly Ser His Ala Val Asn Gly Val Ala Arg Ile His Ser Glu Ile Leu
    450                 455                 460                 
Lys Lys Thr Ile Phe Lys Asp Phe Tyr Glu Leu Glu Pro His Lys Phe
465                 470                 475                 480 
Gln Asn Lys Thr Asn Gly Ile Thr Pro Arg Arg Trp Leu Val Leu Cys
                485                 490                 495     
Asn Pro Gly Leu Ala Glu Val Ile Ala Glu Arg Ile Gly Glu Asp Phe
            500                 505                 510         
Ile Ser Asp Leu Asp Gln Leu Arg Lys Leu Leu Ser Phe Val Asp Asp
        515                 520                 525             
Glu Ala Phe Ile Arg Asp Val Ala Lys Val Lys Gln Glu Asn Lys Leu
    530                 535                 540                 
Lys Phe Ala Ala Tyr Leu Glu Arg Glu Tyr Lys Val His Ile Asn Pro
545                 550                 555                 560 
Asn Ser Leu Phe Asp Ile Gln Val Lys Arg Ile His Glu Tyr Lys Arg
                565                 570                 575     
Gln Leu Leu Asn Cys Leu His Val Ile Thr Leu Tyr Asn Arg Ile Lys
            580                 585                 590         
Arg Glu Pro Asn Lys Phe Phe Val Pro Arg Thr Val Met Ile Gly Gly
        595                 600                 605             
Lys Ala Ala Pro Gly Tyr His Met Ala Lys Met Ile Ile Arg Leu Val
    610                 615                 620                 
Thr Ala Ile Gly Asp Val Val Asn His Asp Pro Ala Val Gly Asp Arg
625                 630                 635                 640 
Leu Arg Val Ile Phe Leu Glu Asn Tyr Arg Val Ser Leu Ala Glu Lys
                645                 650                 655     
Val Ile Pro Ala Ala Asp Leu Ser Glu Gln Ile Ser Thr Ala Gly Thr
            660                 665                 670         
Glu Ala Ser Gly Thr Gly Asn Met Lys Phe Met Leu Asn Gly Ala Leu
        675                 680                 685             
Thr Ile Gly Thr Met Asp Gly Ala Asn Val Glu Met Ala Glu Glu Ala
    690                 695                 700                 
Gly Glu Glu Asn Phe Phe Ile Phe Gly Met Arg Val Glu Asp Val Asp
705                 710                 715                 720 
Lys Leu Asp Gln Arg Gly Tyr Asn Ala Gln Glu Tyr Tyr Asp Arg Ile
                725                 730                 735     
Pro Glu Leu Arg Gln Val Ile Glu Gln Leu Ser Ser Gly Phe Phe Ser
            740                 745                 750         
Pro Lys Gln Pro Asp Leu Phe Lys Asp Ile Val Asn Met Leu Met His
        755                 760                 765             
His Asp Arg Phe Lys Val Phe Ala Asp Tyr Glu Asp Tyr Ile Lys Cys
    770                 775                 780                 
Gln Glu Lys Val Ser Ala Leu Tyr Lys Asn Pro Arg Glu Trp Thr Arg
785                 790                 795                 800 
Met Val Ile Arg Asn Ile Ala Thr Ser Gly Lys Phe Ser Ser Asp Arg
                805                 810                 815     
Thr Ile Ala Gln Tyr Ala Arg Glu Ile Trp Gly Val Glu Pro Ser Arg
            820                 825                 830         
Gln Arg Leu Pro Ala Pro Asp Glu Ala Ile
        835                 840         


<210> 77
<211> 104
<212> PRT
<213> Homo sapiens

<400> 77
Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala Arg Asp
 1               5                  10                  15      
Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile Gly Ser
            20                  25                  30          
Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys Arg Gly
        35                  40                  45              
Pro Gly Gly Ala Trp Ala Ala Glu Val Ile Ser Asn Ala Arg Glu Asn
    50                  55                  60                  
Ile Gln Arg Leu Thr Gly His Gly Ala Glu Asp Ser Leu Ala Asp Gln
65                  70                  75                  80  
Ala Ala Asn Lys Trp Gly Arg Ser Gly Arg Asp Pro Asn His Phe Arg
                85                  90                  95      
Pro Ala Gly Leu Pro Glu Lys Tyr
            100                 


<210> 78
<211> 195
<212> PRT
<213> Homo sapiens

<400> 78
Met Ala Pro Lys Lys Pro Glu Pro Lys Lys Asp Asp Ala Lys Ala Ala
 1               5                  10                  15      
Pro Lys Ala Ala Pro Ala Pro Glu Pro Pro Pro Glu Pro Glu Arg Pro
            20                  25                  30          
Lys Glu Val Glu Phe Asp Ala Ser Lys Ile Lys Ile Glu Phe Thr Pro
        35                  40                  45              
Glu Gln Ile Glu Glu Phe Lys Glu Ala Phe Met Leu Phe Asp Arg Thr
    50                  55                  60                  
Pro Lys Cys Glu Met Lys Ile Thr Tyr Gly Gln Cys Gly Asp Val Leu
65                  70                  75                  80  
Arg Ala Leu Gly Gln Asn Pro Thr Gln Ala Glu Val Leu Arg Val Leu
                85                  90                  95      
Gly Asn Arg Ser Lys Glu Glu Leu Asn Thr Lys Met Met Asp Phe Glu
            100                 105                 110         
Thr Phe Leu Pro Met Leu Gln His Ile Ser Lys Asn Lys Asp Thr Gly
        115                 120                 125             
Thr Tyr Glu Asp Phe Val Glu Gly Leu Arg Val Phe Asp Lys Glu Gly
    130                 135                 140                 
Asn Gly Thr Val Met Gly Ala Glu Leu Arg His Val Leu Ala Thr Leu
145                 150                 155                 160 
Gly Glu Arg Leu Thr Glu Asp Glu Val Glu Lys Leu Met Ala Gly Gln
                165                 170                 175     
Glu Asp Ser Asn Gly Cys Ile Asn Tyr Glu Ala Phe Val Lys His Ile
            180                 185                 190         
Met Ser Ser
        195 


<210> 79
<211> 594
<212> PRT
<213> Homo sapiens

<400> 79
Phe Gly Gly Ser Arg Ala Gly Pro Leu Ser Gly Lys Lys Phe Gly Asn
 1               5                  10                  15      
Pro Gly Glu Lys Leu Val Lys Lys Lys Trp Asn Leu Asp Glu Leu Pro
            20                  25                  30          
Lys Phe Glu Lys Asn Phe Tyr Gln Glu His Pro Asp Leu Ala Arg Arg
        35                  40                  45              
Thr Ala Gln Glu Val Glu Thr Tyr Arg Arg Ser Lys Glu Ile Thr Val
    50                  55                  60                  
Arg Gly His Asn Cys Pro Lys Pro Val Leu Asn Phe Tyr Glu Ala Asn
65                  70                  75                  80  
Phe Pro Ala Asn Val Met Asp Val Ile Ala Arg Gln Asn Phe Thr Glu
                85                  90                  95      
Pro Thr Ala Ile Gln Ala Gln Gly Trp Pro Val Ala Leu Ser Gly Leu
            100                 105                 110         
Asp Met Val Gly Val Ala Gln Thr Gly Ser Gly Lys Thr Leu Ser Tyr
        115                 120                 125             
Leu Leu Pro Ala Ile Val His Ile Asn His Gln Pro Phe Leu Glu Arg
    130                 135                 140                 
Gly Asp Gly Pro Ile Cys Leu Val Leu Ala Pro Thr Arg Glu Leu Ala
145                 150                 155                 160 
Gln Gln Val Gln Gln Val Ala Ala Glu Tyr Cys Arg Ala Cys Arg Leu
                165                 170                 175     
Lys Ser Thr Cys Ile Tyr Gly Gly Ala Pro Lys Gly Pro Gln Ile Arg
            180                 185                 190         
Asp Leu Glu Arg Gly Val Glu Ile Cys Ile Ala Thr Pro Gly Arg Leu
        195                 200                 205             
Ile Asp Phe Leu Glu Cys Gly Lys Thr Asn Leu Arg Arg Thr Thr Tyr
    210                 215                 220                 
Leu Val Leu Asp Glu Ala Asp Arg Met Leu Asp Met Gly Phe Glu Pro
225                 230                 235                 240 
Gln Ile Arg Lys Ile Val Asp Gln Ile Arg Pro Asp Arg Gln Thr Leu
                245                 250                 255     
Met Trp Ser Ala Thr Trp Pro Lys Glu Val Arg Gln Leu Ala Glu Asp
            260                 265                 270         
Phe Leu Lys Asp Tyr Ile His Ile Asn Ile Gly Ala Leu Glu Leu Ser
        275                 280                 285             
Ala Asn His Asn Ile Leu Gln Ile Val Asp Val Cys His Asp Val Glu
    290                 295                 300                 
Lys Asp Glu Lys Leu Ile Arg Leu Met Glu Glu Ile Met Ser Glu Lys
305                 310                 315                 320 
Glu Asn Lys Thr Ile Val Phe Val Glu Thr Lys Arg Arg Cys Asp Glu
                325                 330                 335     
Leu Thr Arg Lys Met Arg Arg Asp Gly Trp Pro Ala Met Gly Ile His
            340                 345                 350         
Gly Asp Lys Ser Gln Gln Glu Arg Asp Trp Val Leu Asn Glu Phe Lys
        355                 360                 365             
His Gly Lys Ala Pro Ile Leu Ile Ala Thr Asp Val Ala Ser Arg Gly
    370                 375                 380                 
Leu Asp Val Glu Asp Val Lys Phe Val Ile Asn Tyr Asp Tyr Pro Asn
385                 390                 395                 400 
Ser Ser Glu Asp Tyr Ile His Arg Ile Gly Arg Thr Ala Arg Ser Thr
                405                 410                 415     
Lys Thr Gly Thr Ala Tyr Thr Phe Phe Thr Pro Asn Asn Ile Lys Gln
            420                 425                 430         
Val Ser Asp Leu Ile Ser Val Leu Arg Glu Ala Asn Gln Ala Ile Asn
        435                 440                 445             
Pro Lys Leu Leu Gln Leu Val Glu Asp Arg Gly Ser Gly Arg Ser Arg
    450                 455                 460                 
Gly Arg Gly Gly Met Lys Asp Asp Arg Arg Asp Arg Tyr Ser Ala Gly
465                 470                 475                 480 
Lys Arg Gly Gly Phe Asn Thr Phe Arg Asp Arg Glu Asn Tyr Asp Arg
                485                 490                 495     
Gly Tyr Ser Ser Leu Leu Lys Arg Asp Phe Gly Ala Lys Thr Gln Asn
            500                 505                 510         
Gly Val Tyr Ser Ala Ala Asn Tyr Thr Asn Gly Ser Phe Gly Ser Asn
        515                 520                 525             
Phe Val Ser Ala Gly Ile Gln Thr Ser Phe Arg Thr Gly Asn Pro Thr
    530                 535                 540                 
Gly Thr Tyr Gln Asn Gly Tyr Asp Ser Thr Gln Gln Tyr Gly Ser Asn
545                 550                 555                 560 
Val Pro Asn Met His Asn Gly Met Asn Gln Gln Ala Tyr Ala Tyr Pro
                565                 570                 575     
Ala Thr Ala Ala Ala Pro Met Ile Gly Tyr Pro Met Pro Thr Gly Tyr
            580                 585                 590         
Ser Gln
        


<210> 80
<211> 44
<212> PRT
<213> Homo sapiens

<400> 80
Ile His Ser Leu Pro Pro Glu Gly Lys Leu Gly Ile Met Glu Leu Ala
 1               5                  10                  15      
Val Gly Leu Thr Ser Cys Phe Val Thr Phe Leu Leu Pro Ala Gly Trp
            20                  25                  30          
Ile Leu Ser His Leu Glu Thr Tyr Arg Arg Pro Glu
        35                  40                  


<210> 81
<211> 249
<212> PRT
<213> Homo sapiens

<400> 81
Met Phe Phe Ser Ala Ala Leu Arg Ala Arg Ala Ala Gly Leu Thr Ala
 1               5                  10                  15      
His Trp Gly Arg His Val Arg Asn Leu His Lys Thr Ala Met Gln Asn
            20                  25                  30          
Gly Ala Gly Gly Ala Leu Phe Val His Arg Asp Thr Pro Glu Asn Asn
        35                  40                  45              
Pro Asp Thr Pro Phe Asp Phe Thr Pro Glu Asn Tyr Lys Arg Ile Glu
    50                  55                  60                  
Ala Ile Val Lys Asn Tyr Pro Glu Gly His Lys Ala Ala Ala Val Leu
65                  70                  75                  80  
Pro Val Leu Asp Leu Ala Gln Arg Gln Asn Gly Trp Leu Pro Ile Ser
                85                  90                  95      
Ala Met Asn Lys Val Ala Glu Val Leu Gln Val Pro Pro Met Arg Val
            100                 105                 110         
Tyr Glu Val Ala Thr Phe Tyr Thr Met Tyr Asn Arg Lys Pro Val Gly
        115                 120                 125             
Lys Tyr His Ile Gln Val Gly Thr Thr Thr Pro Cys Met Leu Arg Asn
    130                 135                 140                 
Ser Asp Ser Ile Leu Glu Ala Ile Gln Lys Lys Leu Gly Ile Lys Val
145                 150                 155                 160 
Gly Glu Thr Thr Pro Asp Lys Leu Phe Thr Leu Ile Glu Val Glu Cys
                165                 170                 175     
Leu Gly Ala Cys Val Asn Ala Pro Met Val Gln Ile Asn Asp Asn Tyr
            180                 185                 190         
Tyr Glu Asp Leu Thr Ala Lys Asp Ile Glu Glu Ile Ile Asp Glu Leu
        195                 200                 205             
Lys Ala Gly Lys Ile Pro Lys Pro Gly Pro Arg Ser Gly Arg Phe Ser
    210                 215                 220                 
Cys Glu Pro Ala Gly Gly Leu Thr Ser Leu Thr Glu Pro Pro Lys Gly
225                 230                 235                 240 
Pro Gly Phe Gly Val Gln Ala Gly Leu
                245                 


<210> 82
<211> 779
<212> PRT
<213> Homo sapiens

<400> 82
Thr His Glu Glu His His Ala Ala Lys Thr Leu Gly Ile Gly Lys Ala
 1               5                  10                  15      
Ile Ala Val Leu Thr Ser Gly Gly Asp Ala Gln Gly Met Asn Ala Ala
            20                  25                  30          
Val Arg Ala Val Val Arg Val Gly Ile Phe Thr Gly Ala Arg Val Phe
        35                  40                  45              
Phe Val His Glu Gly Tyr Gln Gly Leu Val Asp Gly Gly Asp His Ile
    50                  55                  60                  
Lys Glu Ala Thr Trp Glu Ser Val Ser Met Met Leu Gln Leu Gly Gly
65                  70                  75                  80  
Thr Val Ile Gly Ser Ala Arg Cys Lys Asp Phe Arg Glu Arg Glu Gly
                85                  90                  95      
Arg Leu Arg Ala Ala Tyr Asn Leu Val Lys Arg Gly Ile Thr Asn Leu
            100                 105                 110         
Cys Val Ile Gly Gly Asp Gly Ser Leu Thr Gly Ala Asp Thr Phe Arg
        115                 120                 125             
Ser Glu Trp Ser Asp Leu Leu Ser Asp Leu Gln Lys Ala Gly Lys Ile
    130                 135                 140                 
Thr Asp Glu Glu Ala Thr Lys Ser Ser Tyr Leu Asn Ile Val Gly Leu
145                 150                 155                 160 
Val Gly Ser Ile Asp Asn Asp Phe Cys Gly Thr Asp Met Thr Ile Gly
                165                 170                 175     
Thr Asp Ser Ala Leu His Arg Ile Met Glu Ile Val Asp Ala Ile Thr
            180                 185                 190         
Thr Thr Ala Gln Ser His Gln Arg Thr Phe Val Leu Glu Val Met Gly
        195                 200                 205             
Arg His Cys Gly Tyr Leu Ala Leu Val Thr Ser Leu Ser Cys Gly Ala
    210                 215                 220                 
Asp Trp Val Phe Ile Pro Glu Cys Pro Pro Asp Asp Asp Trp Glu Glu
225                 230                 235                 240 
His Leu Cys Arg Arg Leu Ser Glu Thr Arg Thr Arg Gly Ser Arg Leu
                245                 250                 255     
Asn Ile Ile Ile Val Ala Glu Gly Ala Ile Asp Lys Asn Gly Lys Pro
            260                 265                 270         
Ile Thr Ser Glu Asp Ile Lys Asn Leu Val Val Lys Arg Leu Gly Tyr
        275                 280                 285             
Asp Thr Arg Val Thr Val Leu Gly His Val Gln Arg Gly Gly Thr Pro
    290                 295                 300                 
Ser Ala Phe Asp Arg Ile Leu Gly Ser Arg Met Gly Val Glu Ala Val
305                 310                 315                 320 
Met Ala Leu Leu Glu Gly Thr Pro Asp Thr Pro Ala Cys Val Val Ser
                325                 330                 335     
Leu Ser Gly Asn Gln Ala Val Arg Leu Pro Leu Met Glu Cys Val Gln
            340                 345                 350         
Val Thr Lys Asp Val Thr Lys Ala Met Asp Glu Lys Lys Phe Asp Glu
        355                 360                 365             
Ala Leu Lys Leu Arg Gly Arg Ser Phe Met Asn Asn Trp Glu Val Tyr
    370                 375                 380                 
Lys Leu Leu Ala His Val Arg Pro Pro Val Ser Lys Ser Gly Ser His
385                 390                 395                 400 
Thr Val Ala Val Met Asn Val Gly Ala Pro Ala Ala Gly Met Asn Ala
                405                 410                 415     
Ala Val Arg Ser Thr Val Arg Ile Gly Leu Ile Gln Gly Asn Arg Val
            420                 425                 430         
Leu Val Val His Asp Gly Phe Glu Gly Leu Ala Lys Gly Gln Ile Glu
        435                 440                 445             
Glu Ala Gly Trp Ser Tyr Val Gly Gly Trp Thr Gly Gln Gly Gly Ser
    450                 455                 460                 
Lys Leu Gly Thr Lys Arg Thr Leu Pro Lys Lys Ser Phe Glu Gln Ile
465                 470                 475                 480 
Ser Ala Asn Ile Thr Lys Phe Asn Ile Gln Gly Leu Val Ile Ile Gly
                485                 490                 495     
Gly Phe Glu Ala Tyr Thr Gly Gly Leu Glu Leu Met Glu Gly Arg Lys
            500                 505                 510         
Gln Phe Asp Glu Leu Cys Ile Pro Phe Val Val Ile Pro Ala Thr Val
        515                 520                 525             
Ser Asn Asn Val Pro Gly Ser Asp Phe Ser Val Gly Ala Asp Thr Ala
    530                 535                 540                 
Leu Asn Thr Ile Cys Thr Thr Cys Asp Arg Ile Lys Gln Ser Ala Ala
545                 550                 555                 560 
Gly Thr Lys Arg Arg Val Phe Ile Ile Glu Thr Met Gly Gly Tyr Cys
                565                 570                 575     
Gly Tyr Leu Ala Thr Met Ala Gly Leu Ala Ala Gly Ala Asp Ala Ala
            580                 585                 590         
Tyr Ile Phe Glu Glu Pro Phe Thr Ile Arg Asp Leu Gln Ala Asn Val
        595                 600                 605             
Glu His Leu Val Gln Lys Met Lys Thr Thr Val Lys Arg Gly Leu Val
    610                 615                 620                 
Leu Arg Asn Glu Lys Cys Asn Glu Asn Tyr Thr Thr Asp Phe Ile Phe
625                 630                 635                 640 
Asn Leu Tyr Ser Glu Glu Gly Lys Gly Ile Phe Asp Ser Arg Lys Asn
                645                 650                 655     
Val Leu Gly His Met Gln Gln Gly Gly Ser Pro Thr Pro Phe Asp Arg
            660                 665                 670         
Asn Phe Ala Thr Lys Met Gly Ala Lys Ala Met Asn Trp Met Ala Gly
        675                 680                 685             
Lys Ile Lys Glu Ser Tyr Arg Asn Gly Arg Ile Phe Ala Asn Thr Pro
    690                 695                 700                 
Asp Ser Gly Cys Val Leu Gly Met Arg Lys Arg Ala Leu Val Phe Gln
705                 710                 715                 720 
Pro Val Ala Glu Leu Lys Asp Gln Thr Asp Phe Glu His Arg Ile Pro
                725                 730                 735     
Lys Glu Gln Trp Trp Leu Lys Leu Arg Pro Ile Leu Lys Ile Leu Ala
            740                 745                 750         
Lys Tyr Glu Ile Asp Leu Asp Thr Ser Asp His Ala His Leu Glu His
        755                 760                 765             
Ile Thr Arg Lys Arg Ser Gly Glu Ala Ala Val
    770                 775                 


<210> 83
<211> 1452
<212> PRT
<213> Homo sapiens

<400> 83
Met Arg Thr Leu Gly Thr Cys Leu Ala Thr Leu Ala Gly Leu Leu Leu
 1               5                  10                  15      
Thr Ala Ala Gly Glu Thr Phe Ser Gly Gly Cys Leu Phe Asp Glu Pro
            20                  25                  30          
Tyr Ser Thr Cys Gly Tyr Ser Gln Ser Glu Gly Asp Asp Phe Asn Trp
        35                  40                  45              
Glu Gln Val Asn Thr Leu Thr Lys Pro Thr Ser Asp Pro Trp Met Pro
    50                  55                  60                  
Ser Gly Ser Leu Met Leu Val Asn Ala Ser Gly Arg Pro Glu Gly Gln
65                  70                  75                  80  
Arg Ala His Leu Leu Leu Pro Gln Leu Lys Glu Asn Asp Thr His Cys
                85                  90                  95      
Ile Asp Phe His Tyr Phe Val Ser Ser Lys Ser Asn Ser Pro Pro Gly
            100                 105                 110         
Leu Leu Asn Val Tyr Val Lys Val Asn Asn Gly Pro Leu Gly Asn Pro
        115                 120                 125             
Ile Trp Asn Ile Ser Gly Asp Pro Thr Arg Thr Trp Asn Arg Ala Glu
    130                 135                 140                 
Leu Ala Ile Ser Thr Phe Trp Pro Asn Phe Tyr Gln Val Ile Phe Glu
145                 150                 155                 160 
Val Ile Thr Ser Gly His Gln Gly Tyr Leu Ala Ile Asp Glu Val Lys
                165                 170                 175     
Val Leu Gly His Pro Cys Thr Arg Thr Pro His Phe Leu Arg Ile Gln
            180                 185                 190         
Asn Val Glu Val Asn Ala Gly Gln Phe Ala Thr Phe Gln Cys Ser Ala
        195                 200                 205             
Ile Gly Arg Thr Val Ala Gly Asp Arg Leu Trp Leu Gln Gly Ile Asp
    210                 215                 220                 
Val Arg Asp Ala Pro Leu Lys Glu Ile Lys Val Thr Ser Ser Arg Arg
225                 230                 235                 240 
Phe Ile Ala Ser Phe Asn Val Val Asn Thr Thr Lys Arg Asp Ala Gly
                245                 250                 255     
Lys Tyr Arg Cys Met Ile Arg Thr Glu Gly Gly Val Gly Ile Ser Asn
            260                 265                 270         
Tyr Ala Glu Leu Val Val Lys Glu Pro Pro Val Pro Ile Ala Pro Pro
        275                 280                 285             
Gln Leu Ala Ser Val Gly Ala Thr Tyr Leu Trp Ile Gln Leu Asn Ala
    290                 295                 300                 
Asn Ser Ile Asn Gly Asp Gly Pro Ile Val Ala Arg Glu Val Glu Tyr
305                 310                 315                 320 
Cys Thr Ala Ser Gly Ser Trp Asn Asp Arg Gln Pro Val Asp Ser Thr
                325                 330                 335     
Ser Tyr Lys Ile Gly His Leu Asp Pro Asp Thr Glu Tyr Glu Ile Ser
            340                 345                 350         
Val Leu Leu Thr Arg Pro Gly Glu Gly Gly Thr Gly Ser Pro Gly Pro
        355                 360                 365             
Ala Leu Arg Thr Arg Thr Lys Cys Ala Asp Pro Met Arg Gly Pro Arg
    370                 375                 380                 
Lys Leu Glu Val Val Glu Val Lys Ser Arg Gln Ile Thr Ile Arg Trp
385                 390                 395                 400 
Glu Pro Phe Gly Tyr Asn Val Thr Arg Cys His Ser Tyr Asn Leu Thr
                405                 410                 415     
Val His Tyr Cys Tyr Gln Val Gly Gly Gln Glu Gln Val Arg Glu Glu
            420                 425                 430         
Val Ser Trp Asp Thr Glu Asn Ser His Pro Gln His Thr Ile Thr Asn
        435                 440                 445             
Leu Ser Pro Tyr Thr Asn Val Ser Val Lys Leu Ile Leu Met Asn Pro
    450                 455                 460                 
Glu Gly Arg Lys Glu Ser Gln Glu Leu Ile Val Gln Thr Asp Glu Asp
465                 470                 475                 480 
Leu Pro Gly Ala Val Pro Thr Glu Ser Ile Gln Gly Ser Thr Phe Glu
                485                 490                 495     
Glu Lys Ile Phe Leu Gln Trp Arg Glu Pro Thr Gln Thr Tyr Gly Val
            500                 505                 510         
Ile Thr Leu Tyr Glu Ile Thr Tyr Lys Ala Val Ser Ser Phe Asp Pro
        515                 520                 525             
Glu Ile Asp Leu Ser Asn Gln Ser Gly Arg Val Ser Lys Leu Gly Asn
    530                 535                 540                 
Glu Thr His Phe Leu Phe Phe Gly Leu Tyr Pro Gly Thr Thr Tyr Ser
545                 550                 555                 560 
Phe Thr Ile Arg Ala Ser Thr Ala Lys Gly Phe Gly Pro Pro Ala Thr
                565                 570                 575     
Asn Gln Phe Thr Thr Lys Ile Ser Ala Pro Ser Met Pro Ala Tyr Glu
            580                 585                 590         
Leu Glu Thr Pro Leu Asn Gln Thr Asp Asn Thr Val Thr Val Met Leu
        595                 600                 605             
Lys Pro Ala His Ser Arg Gly Ala Pro Val Ser Val Tyr Gln Ile Val
    610                 615                 620                 
Val Glu Glu Glu Arg Pro Arg Arg Thr Lys Lys Thr Thr Glu Ile Leu
625                 630                 635                 640 
Lys Cys Tyr Pro Val Pro Ile His Phe Gln Asn Ala Ser Leu Leu Asn
                645                 650                 655     
Ser Gln Tyr Tyr Phe Ala Ala Glu Phe Pro Ala Asp Ser Leu Gln Ala
            660                 665                 670         
Ala Gln Pro Phe Thr Ile Gly Asp Asn Lys Thr Tyr Asn Gly Tyr Trp
        675                 680                 685             
Asn Thr Pro Leu Leu Pro Tyr Lys Ser Tyr Arg Ile Tyr Tyr Gln Ala
    690                 695                 700                 
Ala Ser Arg Ala Asn Gly Glu Thr Lys Ile Asp Cys Val Gln Val Ala
705                 710                 715                 720 
Thr Lys Gly Ala Ala Thr Pro Lys Pro Val Pro Glu Pro Glu Lys Gln
                725                 730                 735     
Thr Asp His Thr Val Lys Ile Ala Gly Val Ile Ala Gly Ile Leu Leu
            740                 745                 750         
Phe Val Ile Ile Phe Leu Gly Val Val Leu Val Met Lys Lys Arg Lys
        755                 760                 765             
Leu Ala Lys Lys Arg Lys Glu Thr Met Ser Ser Thr Arg Gln Glu Met
    770                 775                 780                 
Thr Val Met Val Asn Ser Met Asp Lys Ser Tyr Ala Glu Gln Gly Thr
785                 790                 795                 800 
Asn Cys Asp Glu Ala Phe Ser Phe Met Asp Thr His Asn Leu Asn Gly
                805                 810                 815     
Arg Ser Val Ser Ser Pro Ser Ser Phe Thr Met Lys Thr Asn Thr Leu
            820                 825                 830         
Ser Thr Ser Val Pro Asn Ser Tyr Tyr Pro Asp Glu Thr His Thr Met
        835                 840                 845             
Ala Ser Asp Thr Ser Ser Leu Val Gln Ser His Thr Tyr Lys Lys Arg
    850                 855                 860                 
Glu Pro Ala Asp Val Pro Tyr Gln Thr Gly Gln Leu His Pro Ala Ile
865                 870                 875                 880 
Arg Val Ala Asp Leu Leu Gln His Ile Thr Gln Met Lys Cys Ala Glu
                885                 890                 895     
Gly Tyr Gly Phe Lys Glu Glu Tyr Glu Ser Phe Phe Glu Gly Gln Ser
            900                 905                 910         
Ala Pro Trp Asp Ser Ala Lys Lys Asp Glu Asn Arg Met Lys Asn Arg
        915                 920                 925             
Tyr Gly Asn Ile Ile Ala Tyr Asp His Ser Arg Val Arg Leu Gln Thr
    930                 935                 940                 
Ile Glu Gly Asp Thr Asn Ser Asp Tyr Ile Asn Gly Asn Tyr Ile Asp
945                 950                 955                 960 
Gly Tyr His Arg Pro Asn His Tyr Ile Ala Thr Gln Gly Pro Met Gln
                965                 970                 975     
Glu Thr Ile Tyr Asp Phe Trp Arg Met Val Trp His Glu Asn Thr Ala
            980                 985                 990         
Ser Ile Ile Met Val Thr Asn Leu Val Glu Val Gly Arg Val Lys Cys
        995                 1000                1005            
Cys Lys Tyr Trp Pro Asp Asp Thr Glu Ile Tyr Lys Asp Ile Lys Val
    1010                1015                1020                
Thr Leu Ile Glu Thr Glu Leu Leu Ala Glu Tyr Val Ile Arg Thr Phe
1025                1030                1035                1040
Ala Val Glu Lys Arg Gly Val His Glu Ile Arg Glu Ile Arg Gln Phe
                1045                1050                1055    
His Phe Thr Gly Trp Pro Asp His Gly Val Pro Tyr His Ala Thr Gly
            1060                1065                1070        
Leu Leu Gly Phe Val Arg Gln Val Lys Ser Lys Ser Pro Pro Ser Ala
        1075                1080                1085            
Gly Pro Leu Val Val His Cys Ser Ala Gly Ala Gly Arg Thr Gly Cys
    1090                1095                1100                
Phe Ile Val Ile Asp Ile Met Leu Asp Met Ala Glu Arg Glu Gly Val
1105                1110                1115                1120
Val Asp Ile Tyr Asn Cys Val Arg Glu Leu Arg Ser Arg Arg Val Asn
                1125                1130                1135    
Met Val Gln Thr Glu Glu Gln Tyr Val Phe Ile His Asp Ala Ile Leu
            1140                1145                1150        
Glu Ala Cys Leu Cys Gly Asp Thr Ser Val Pro Ala Ser Gln Val Arg
        1155                1160                1165            
Ser Leu Tyr Tyr Asp Met Asn Lys Leu Asp Pro Gln Thr Asn Ser Ser
    1170                1175                1180                
Gln Ile Lys Glu Glu Phe Arg Thr Leu Asn Met Val Thr Pro Thr Leu
1185                1190                1195                1200
Arg Val Glu Asp Cys Ser Ile Ala Leu Leu Pro Arg Asn His Glu Lys
                1205                1210                1215    
Asn Arg Cys Met Asp Ile Leu Pro Pro Asp Arg Cys Leu Pro Phe Leu
            1220                1225                1230        
Ile Thr Ile Asp Gly Glu Ser Ser Asn Tyr Ile Asn Ala Ala Leu Met
        1235                1240                1245            
Asp Ser Tyr Lys Gln Pro Ser Ala Phe Ile Val Thr Gln His Pro Leu
    1250                1255                1260                
Pro Asn Thr Val Lys Asp Phe Trp Arg Leu Val Leu Asp Tyr His Cys
1265                1270                1275                1280
Thr Ser Val Val Met Leu Asn Asp Val Asp Pro Ala Gln Leu Cys Pro
                1285                1290                1295    
Gln Tyr Trp Pro Glu Asn Gly Val His Arg His Gly Pro Ile Gln Val
            1300                1305                1310        
Glu Phe Val Ser Ala Asp Leu Glu Glu Asp Ile Ile Ser Arg Ile Phe
        1315                1320                1325            
Arg Ile Tyr Asn Ala Ala Arg Pro Gln Asp Gly His Arg Met Val Gln
    1330                1335                1340                
Gln Phe Gln Phe Leu Gly Trp Pro Met Tyr Arg Asp Thr Pro Val Ser
1345                1350                1355                1360
Lys Arg Ser Ala Leu Leu Leu Ile Arg Gln Val Asp Lys Trp Gln Glu
                1365                1370                1375    
Glu Tyr Asn Gly Gly Glu Gly Pro Thr Val Val His Cys Leu Asn Gly
            1380                1385                1390        
Gly Gly Arg Ser Gly Thr Phe Cys Ala Ile Ser Ile Val Cys Glu Met
        1395                1400                1405            
Leu Arg His Gln Arg Thr Val Asp Val Phe His Ala Val Lys Thr Leu
    1410                1415                1420                
Arg Asn Asn Lys Pro Asn Met Val Asp Leu Leu Asp Gln Tyr Lys Phe
1425                1430                1435                1440
Cys Tyr Glu Val Ala Leu Glu Tyr Leu Asn Ser Gly
                1445                1450        


<210> 84
<211> 146
<212> PRT
<213> Homo sapiens

<400> 84
Val His Leu Thr Pro Glu Glu Lys Ser Ala Val Thr Ala Leu Trp Gly
 1               5                  10                  15      
Lys Val Asp Val Asp Glu Val Gly Gly Glu Ala Leu Gly Arg Leu Leu
            20                  25                  30          
Val Val Tyr Pro Trp Thr Glu Arg Phe Phe Glu Ser Phe Gly Asp Leu
        35                  40                  45              
Ser Thr Pro Asp Ala Val Met Gly Asp Pro Lys Val Lys Ala His Gly
    50                  55                  60                  
Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp Asp
65                  70                  75                  80  
Leu Lys Gly Thr Phe Ala Thr Leu Ser Glu Leu His Cys Asp Lys Leu
                85                  90                  95      
His Val Asp Pro Glu Asp Phe Arg Leu Leu Gly Asp Val Leu Val Cys
            100                 105                 110         
Val Leu Ala His His Phe Gly Lys Glu Phe Thr Pro Pro Val Glu Ala
        115                 120                 125             
Ala Tyr Glu Lys Val Val Ala Gly Val Ala Asp Ala Leu Ala His Lys
    130                 135                 140                 
Tyr His
145     


<210> 85
<211> 245
<212> PRT
<213> Homo sapiens

<400> 85
Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr
 1               5                  10                  15      
Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln
            20                  25                  30          
Phe Gln Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Trp
        35                  40                  45              
Asp Asp Val Thr Ser Thr Phe Ser Lys Leu Arg Gln Glu Leu Gly Pro
    50                  55                  60                  
Val Thr Glu Glu Trp Phe Asn Asp Leu Gln Glu Lys Leu Asn Leu Glu
65                  70                  75                  80  
Lys Glu Thr Gly Glu Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu
                85                  90                  95      
Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp
            100                 105                 110         
Gln Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu
        115                 120                 125             
Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu
    130                 135                 140                 
Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp
145                 150                 155                 160 
Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg
                165                 170                 175     
Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Ala Gly Arg Leu
            180                 185                 190         
Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu
        195                 200                 205             
Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val
    210                 215                 220                 
Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr
225                 230                 235                 240 
Lys Leu Asn Thr Gln
                245 


<210> 86
<211> 245
<212> PRT
<213> Homo sapiens

<400> 86
Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr
 1               5                  10                  15      
Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln
            20                  25                  30          
Phe Gln Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Trp
        35                  40                  45              
Asp Asp Val Thr Ser Thr Phe Ser Lys Leu Arg Gln Glu Leu Gly Pro
    50                  55                  60                  
Val Thr Glu Glu Trp Phe Asn Asp Leu Gln Glu Lys Leu Asn Leu Glu
65                  70                  75                  80  
Lys Glu Thr Gly Glu Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu
                85                  90                  95      
Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp
            100                 105                 110         
Gln Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu
        115                 120                 125             
Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu
    130                 135                 140                 
Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp
145                 150                 155                 160 
Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg
                165                 170                 175     
Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Ala Gly Arg Leu
            180                 185                 190         
Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu
        195                 200                 205             
Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val
    210                 215                 220                 
Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr
225                 230                 235                 240 
Lys Leu Asn Thr Gln
                245 


<210> 87
<211> 218
<212> PRT
<213> Homo sapiens

<400> 87
Ile Val Gly Gly Arg Arg Ala Arg Pro His Ala Trp Pro Phe Met Val
 1               5                  10                  15      
Ser Leu Gln Leu Arg Gly Gly His Phe Cys Gly Ala Thr Leu Ile Ala
            20                  25                  30          
Pro Asn Phe Val Met Ser Ala Ala His Cys Val Ala Asn Val Asn Val
        35                  40                  45              
Arg Ala Val Arg Val Val Leu Gly Ala His Asn Leu Ser Arg Arg Glu
    50                  55                  60                  
Pro Thr Arg Gln Val Phe Ala Val Gln Arg Ile Phe Glu Asp Gly Tyr
65                  70                  75                  80  
Asp Pro Val Asn Leu Leu Asn Asp Ile Val Ile Leu Gln Leu Asn Gly
                85                  90                  95      
Ser Ala Thr Ile Asn Ala Asn Val Gln Val Ala Gln Leu Pro Ala Gln
            100                 105                 110         
Gly Arg Arg Leu Gly Asn Gly Val Gln Cys Leu Ala Met Gly Trp Gly
        115                 120                 125             
Leu Leu Gly Arg Asn Arg Gly Ile Ala Ser Val Leu Gln Glu Leu Asn
    130                 135                 140                 
Val Thr Val Val Thr Ser Leu Cys Arg Arg Ser Asn Val Cys Thr Leu
145                 150                 155                 160 
Val Arg Gly Arg Gln Ala Gly Val Cys Phe Gly Asp Ser Gly Ser Pro
                165                 170                 175     
Leu Val Cys Asn Gly Leu Ile His Gly Ile Ala Ser Phe Val Arg Gly
            180                 185                 190         
Gly Cys Ala Ser Gly Leu Tyr Pro Asp Ala Phe Ala Pro Val Ala Gln
        195                 200                 205             
Phe Val Asn Trp Ile Asp Ser Ile Ile Gln
    210                 215             


<210> 88
<211> 292
<212> PRT
<213> Homo sapiens

<400> 88
Met Glu Leu Leu Cys Cys Glu Gly Thr Arg His Ala Pro Arg Ala Gly
 1               5                  10                  15      
Pro Asp Pro Arg Leu Leu Gly Asp Gln Arg Val Leu Gln Ser Leu Leu
            20                  25                  30          
Arg Leu Glu Glu Arg Tyr Val Pro Arg Ala Ser Tyr Phe Gln Cys Val
        35                  40                  45              
Gln Arg Glu Ile Lys Pro His Met Arg Lys Met Leu Ala Tyr Trp Met
    50                  55                  60                  
Leu Glu Val Cys Glu Glu Gln Arg Cys Glu Glu Glu Val Phe Pro Leu
65                  70                  75                  80  
Ala Met Asn Tyr Leu Asp Arg Tyr Leu Ser Cys Val Pro Thr Arg Lys
                85                  90                  95      
Ala Gln Leu Gln Leu Leu Gly Ala Val Cys Met Leu Leu Ala Ser Lys
            100                 105                 110         
Leu Arg Glu Thr Thr Pro Leu Thr Ile Glu Lys Leu Cys Ile Tyr Thr
        115                 120                 125             
Asp His Ala Val Ser Pro Arg Gln Leu Arg Asp Trp Glu Val Leu Val
    130                 135                 140                 
Leu Gly Lys Leu Lys Trp Asp Leu Ala Ala Val Ile Ala His Asp Phe
145                 150                 155                 160 
Leu Ala Phe Ile Leu His Arg Leu Ser Leu Pro Arg Asp Arg Gln Ala
                165                 170                 175     
Leu Val Lys Lys His Ala Gln Thr Phe Leu Ala Leu Cys Ala Thr Asp
            180                 185                 190         
Tyr Thr Phe Ala Met Tyr Pro Pro Ser Met Ile Ala Thr Gly Ser Ile
        195                 200                 205             
Gly Ala Ala Val Gln Gly Leu Gly Ala Cys Ser Met Ser Gly Asp Glu
    210                 215                 220                 
Leu Thr Glu Leu Leu Ala Gly Ile Thr Gly Thr Glu Val Asp Cys Leu
225                 230                 235                 240 
Arg Ala Cys Gln Glu Gln Ile Glu Ala Ala Leu Arg Glu Ser Leu Arg
                245                 250                 255     
Glu Ala Ala Gln Thr Ser Ser Ser Pro Ala Pro Lys Ala Pro Arg Gly
            260                 265                 270         
Ser Ser Ser Gln Gly Pro Ser Gln Thr Ser Thr Pro Thr Asp Val Thr
        275                 280                 285             
Ala Ile His Leu
    290         


<210> 89
<211> 12
<212> PRT
<213> Homo sapiens

<400> 89
Thr Phe Ile Ala Ile Lys Pro Asp Gly Val Gln Arg
 1               5                  10          


<210> 90
<211> 282
<212> PRT
<213> Homo sapiens

<400> 90
Ala Val Pro Pro Thr Tyr Ala Asp Leu Gly Lys Ser Ala Arg Asp Val
 1               5                  10                  15      
Phe Thr Lys Gly Tyr Gly Phe Gly Leu Ile Lys Leu Asp Leu Lys Thr
            20                  25                  30          
Lys Ser Glu Asn Gly Leu Glu Phe Thr Ser Ser Gly Ser Ala Asn Thr
        35                  40                  45              
Glu Thr Thr Lys Val Thr Gly Ser Leu Glu Thr Lys Tyr Arg Trp Thr
    50                  55                  60                  
Glu Tyr Gly Leu Thr Phe Thr Glu Lys Trp Asn Thr Asp Asn Thr Leu
65                  70                  75                  80  
Gly Thr Glu Ile Thr Val Glu Asp Gln Leu Ala Arg Gly Leu Lys Leu
                85                  90                  95      
Thr Phe Asp Ser Ser Phe Ser Pro Asn Thr Gly Lys Lys Asn Ala Lys
            100                 105                 110         
Ile Lys Thr Gly Tyr Lys Arg Glu His Ile Asn Leu Gly Cys Asp Met
        115                 120                 125             
Asp Phe Asp Ile Ala Gly Pro Ser Ile Arg Gly Ala Leu Val Leu Gly
    130                 135                 140                 
Tyr Glu Gly Trp Leu Ala Gly Tyr Gln Met Asn Phe Glu Thr Ala Lys
145                 150                 155                 160 
Ser Arg Val Thr Gln Ser Asn Phe Ala Val Gly Tyr Lys Thr Asp Glu
                165                 170                 175     
Phe Gln Leu His Thr Asn Val Asn Asp Gly Thr Glu Phe Gly Gly Ser
            180                 185                 190         
Ile Tyr Gln Lys Val Asn Lys Lys Leu Glu Thr Ala Val Asn Leu Ala
        195                 200                 205             
Trp Thr Ala Gly Asn Ser Asn Thr Arg Phe Gly Ile Ala Ala Lys Tyr
    210                 215                 220                 
Gln Ile Asp Pro Asp Ala Cys Phe Ser Ala Lys Val Asn Asn Ser Ser
225                 230                 235                 240 
Leu Ile Gly Leu Gly Tyr Thr Gln Thr Leu Lys Pro Gly Ile Lys Leu
                245                 250                 255     
Thr Leu Ser Ala Leu Leu Asp Gly Lys Asn Val Asn Ala Gly Gly His
            260                 265                 270         
Lys Leu Gly Leu Gly Leu Glu Phe Gln Ala
        275                 280         


<210> 91
<211> 24
<212> PRT
<213> Homo sapiens

<400> 91
Gln Phe Phe Asp Leu Met Lys Leu Phe Glu Val Gly Gly Ser Pro Ser
 1               5                  10                  15      
Asn Ala Arg Tyr Leu Phe Leu Gly
            20                  


<210> 92
<211> 1003
<212> PRT
<213> Homo sapiens

<400> 92
Met Phe His Leu Arg Thr Cys Ala Ala Lys Leu Arg Pro Leu Thr Ala
 1               5                  10                  15      
Ser Gln Thr Val Lys Thr Phe Ser Gln Asn Arg Pro Ala Ala Ala Arg
            20                  25                  30          
Thr Phe Gln Gln Ile Arg Cys Tyr Ser Ala Pro Val Ala Ala Glu Pro
        35                  40                  45              
Phe Leu Ser Gly Thr Ser Ser Asn Tyr Val Glu Glu Met Tyr Cys Ala
    50                  55                  60                  
Trp Leu Glu Asn Pro Lys Ser Val His Lys Ser Trp Asp Ile Phe Phe
65                  70                  75                  80  
Arg Asn Thr Asn Ala Gly Ala Pro Pro Ala Leu Leu Pro Glu Ser Pro
                85                  90                  95      
Ser Leu Ser Arg Gly Ser Leu Ala Ala Val Ala His Ala Gln Ser Leu
            100                 105                 110         
Val Glu Ala Gln Pro Asn Val Asp Lys Leu Val Glu Asp His Leu Ala
        115                 120                 125             
Val Gln Ser Leu Ile Arg Ala Tyr Gln Ile Arg Gly His His Val Ala
    130                 135                 140                 
Gln Leu Asp Pro Leu Gly Ile Leu Asp Ala Asp Leu Asp Ser Ser Val
145                 150                 155                 160 
Ala Pro Leu Thr Leu Ser His Pro Gln Thr Asn Leu Gly Ser Met Ala
                165                 170                 175     
Trp Met Ser Leu Thr Ser Thr Arg Ser Ser Thr Cys Pro Pro Thr Thr
            180                 185                 190         
Phe Ile Gly Gly Gln Glu Ser Ala Leu Pro Leu Arg Glu Ile Ile Arg
        195                 200                 205             
Arg Leu Glu Met Ala Tyr Cys Gln His Ile Gly Val Glu Phe Met Phe
    210                 215                 220                 
Ile Asn Asp Leu Glu Gln Cys Gln Trp Ile Arg Gln Lys Phe Glu Thr
225                 230                 235                 240 
Pro Gly Ile Met Gln Phe Thr Asn Glu Glu Lys Arg Thr Leu Leu Ala
                245                 250                 255     
Arg Leu Val Arg Ser Thr Arg Phe Glu Glu Phe Leu Gln Arg Lys Trp
            260                 265                 270         
Ser Ser Glu Lys Arg Phe Gly Leu Glu Gly Cys Glu Val Leu Ile Pro
        275                 280                 285             
Ala Leu Lys Thr Ile Ile Asp Lys Ser Ser Glu Asn Gly Val Asp Tyr
    290                 295                 300                 
Val Ile Met Gly Met Pro His Arg Gly Arg Leu Asn Val Leu Ala Asn
305                 310                 315                 320 
Val Ile Arg Lys Glu Leu Glu Gln Ile Phe Cys Gln Phe Asp Ser Lys
                325                 330                 335     
Leu Glu Ala Ala Asp Glu Gly Leu Arg Arg Cys Glu Val Pro Pro Gly
            340                 345                 350         
His Val Ser Pro Gln Asp Gln Ser Cys His Arg Pro Gly Thr Leu Pro
        355                 360                 365             
Cys Pro Trp Trp Pro Asn Pro Ser His Leu Glu Ala Ala Asp Pro Val
    370                 375                 380                 
Val Met Gly Lys Thr Lys Ala Glu Gln Phe Tyr Cys Gly Asp Thr Glu
385                 390                 395                 400 
Gly Lys Lys Val Met Ser Ile Leu Leu His Gly Asp Ala Ala Phe Ala
                405                 410                 415     
Gly Gln Gly Ile Val Tyr Glu Thr Phe His Leu Ser Asp Leu Pro Ser
            420                 425                 430         
Tyr Thr Thr His Gly Thr Val His Val Val Val Asn Asn Gln Ile Gly
        435                 440                 445             
Phe Thr Thr Asp Pro Arg Met Ala Arg Ser Ser Pro Tyr Pro Thr Asp
    450                 455                 460                 
Val Ala Arg Val Val Asn Ala Pro Ile Phe His Val Asn Ser Asp Asp
465                 470                 475                 480 
Pro Glu Ala Val Met Tyr Val Cys Lys Val Ala Ala Glu Trp Arg Ser
                485                 490                 495     
Thr Phe His Lys Asp Val Val Val Asp Leu Val Cys Tyr Arg Arg Asn
            500                 505                 510         
Gly His Asn Glu Met Asp Glu Pro Met Phe Thr Gln Pro Leu Met Tyr
        515                 520                 525             
Lys Gln Ile Arg Lys Gln Lys Pro Val Leu Gln Lys Tyr Ala Glu Leu
    530                 535                 540                 
Leu Val Ser Gln Gly Val Val Asn Gln Pro Glu Tyr Glu Glu Glu Ile
545                 550                 555                 560 
Ser Lys Tyr Asp Lys Ile Cys Glu Glu Ala Phe Ala Arg Ser Lys Asp
                565                 570                 575     
Glu Lys Ile Leu His Ile Lys His Trp Leu Asp Ser Pro Trp Pro Gly
            580                 585                 590         
Phe Phe Thr Leu Asp Gly Gln Pro Arg Ser Met Ser Cys Pro Ser Thr
        595                 600                 605             
Gly Leu Thr Glu Asp Ile Leu Thr His Ile Gly Asn Val Ala Ser Ser
    610                 615                 620                 
Val Pro Val Glu Asn Phe Thr Ile His Gly Gly Leu Ser Arg Ile Leu
625                 630                 635                 640 
Lys Thr Arg Gly Glu Met Val Lys Asn Arg Thr Val Asp Trp Ala Leu
                645                 650                 655     
Ala Glu Tyr Met Ala Phe Gly Ser Leu Leu Lys Glu Gly Ile His Ile
            660                 665                 670         
Arg Leu Ser Gly Gln Asp Val Glu Arg Gly Thr Phe Ser His Arg His
        675                 680                 685             
His Val Leu His Asp Gln Asn Val Asp Lys Arg Thr Cys Ile Pro Met
    690                 695                 700                 
Asn His Leu Trp Pro Asn Gln Ala Pro Tyr Thr Val Cys Asn Ser Ser
705                 710                 715                 720 
Leu Ser Glu Tyr Gly Val Leu Gly Phe Gly Ala Gly Leu Arg Met Ala
                725                 730                 735     
Ser Pro Asn Ala Leu Val Leu Trp Glu Ala Gln Phe Gly Asp Phe His
            740                 745                 750         
Asn Thr Ala Gln Cys Ile Ile Asp Gln Phe Ile Cys Pro Gly Gln Ala
        755                 760                 765             
Lys Trp Val Arg Gln Asn Gly Ile Val Leu Leu Leu Pro Leu Gly Met
    770                 775                 780                 
Glu Gly Met Gly Pro Glu His Ser Ser Gly Pro Pro Arg Ala Phe Leu
785                 790                 795                 800 
Gln Met Cys Asn Asp Asp Pro Asp Val Leu Pro Asp Leu Lys Glu Ala
                805                 810                 815     
Asn Phe Asp Ile Asn Gln Leu Tyr Asp Cys Asn Trp Val Val Val Asn
            820                 825                 830         
Cys Ser Thr Pro Gly Asn Phe Phe His Val Leu Arg Arg Gln Ile Leu
        835                 840                 845             
Leu Pro Phe Arg Lys Pro Leu Ile Ile Phe Thr Pro Lys Ser Leu Leu
    850                 855                 860                 
Arg His Pro Glu Ala Arg Ser Ser Phe Asp Glu Met Leu Pro Gly Thr
865                 870                 875                 880 
His Phe Gln Arg Val Ile Pro Glu Asp Gly Pro Ala Ala Gln Asn Pro
                885                 890                 895     
Glu Asn Val Lys Arg Leu Leu Phe Cys Thr Gly Lys Val Tyr Tyr Asp
            900                 905                 910         
Leu Thr Arg Glu Arg Lys Ala Arg Asp Met Val Gly Gln Val Ala Ile
        915                 920                 925             
Thr Arg Ile Glu His Val Ser Pro Phe Pro Phe Asp Leu Leu Leu Lys
    930                 935                 940                 
Glu Val Gln Lys Tyr Pro Asn Ala Glu Leu Ala Trp Cys Gln Glu Glu
945                 950                 955                 960 
His Lys Asn Gln Gly Tyr Tyr Asp Tyr Val Lys Pro Arg Leu Arg Thr
                965                 970                 975     
Thr Ile Ser Arg Ala Lys Pro Val Trp Tyr Ala Gly Arg Asp Pro Ala
            980                 985                 990         
Ala Ala Pro Arg Thr Gly Asn Lys Lys Thr His
        995                 1000            


<210> 93
<211> 99
<212> PRT
<213> Homo sapiens

<400> 93
Arg Ser Lys Trp Ser Glu Arg Thr Arg Lys Pro Leu Glu Ala Leu Tyr
 1               5                  10                  15      
Gly Tyr Asp Tyr Phe Ala Arg Thr Cys Glu Lys Trp Val Asp Gly Ile
            20                  25                  30          
Arg Gln Phe Lys His Leu Pro Asp Gly Asn Ile Cys Arg His Leu Leu
        35                  40                  45              
Pro Arg Val Gln Cys Pro Ala Leu Ile Val His Gly Glu Lys Asp Pro
    50                  55                  60                  
Leu Val Pro Arg Phe His Ala Asp Phe Ile His Lys His Val Lys Ala
65                  70                  75                  80  
Ser Arg Leu His Leu Met Pro Glu Gly Lys His Asn Leu His Leu Arg
                85                  90                  95      
Phe Ala Asp
            


<210> 94
<211> 445
<212> PRT
<213> Homo sapiens

<400> 94
Met Asp Glu Glu Tyr Asp Val Ile Val Leu Gly Thr Gly Leu Thr Glu
 1               5                  10                  15      
Cys Ile Leu Ser Gly Ile Met Ser Val Asn Gly Lys Lys Val Leu His
            20                  25                  30          
Met Asp Arg Asn Pro Tyr Tyr Gly Gly Glu Ser Ala Ser Ile Thr Pro
        35                  40                  45              
Leu Glu Asp Leu Tyr Lys Arg Phe Lys Ile Pro Gly Ser Pro Pro Glu
    50                  55                  60                  
Ser Met Gly Arg Gly Arg Asp Trp Asn Val Asp Leu Ile Pro Lys Phe
65                  70                  75                  80  
Leu Met Ala Asn Gly Gln Leu Val Lys Met Leu Leu Tyr Thr Glu Val
                85                  90                  95      
Thr Arg Tyr Leu Asp Phe Lys Val Thr Glu Gly Ser Phe Val Tyr Lys
            100                 105                 110         
Gly Gly Lys Ile Tyr Lys Val Pro Ser Thr Glu Ala Glu Ala Leu Ala
        115                 120                 125             
Ser Ser Leu Met Gly Leu Phe Glu Lys Arg Arg Phe Arg Lys Phe Leu
    130                 135                 140                 
Val Tyr Val Ala Asn Phe Asp Glu Lys Asp Pro Arg Thr Phe Glu Gly
145                 150                 155                 160 
Ile Asp Pro Lys Lys Thr Thr Met Arg Asp Val Tyr Lys Lys Phe Asp
                165                 170                 175     
Leu Gly Gln Asp Val Ile Asp Phe Thr Gly His Ala Leu Ala Leu Tyr
            180                 185                 190         
Arg Thr Asp Asp Tyr Leu Asp Gln Pro Cys Tyr Glu Thr Ile Asn Arg
        195                 200                 205             
Ile Lys Leu Tyr Ser Glu Ser Leu Ala Arg Tyr Gly Lys Ser Pro Tyr
    210                 215                 220                 
Leu Tyr Pro Leu Tyr Gly Leu Gly Glu Leu Pro Gln Gly Phe Ala Arg
225                 230                 235                 240 
Leu Ser Ala Ile Tyr Gly Gly Thr Tyr Met Leu Asn Lys Pro Ile Glu
                245                 250                 255     
Glu Ile Ile Val Gln Asn Gly Lys Val Ile Gly Val Lys Ser Glu Gly
            260                 265                 270         
Glu Ile Ala Arg Cys Lys Gln Leu Ile Cys Asp Pro Ser Tyr Val Lys
        275                 280                 285             
Asp Arg Val Glu Lys Val Gly Gln Val Ile Arg Val Ile Cys Ile Leu
    290                 295                 300                 
Ser His Pro Ile Lys Asn Thr Asn Asp Ala Asn Ser Cys Gln Ile Ile
305                 310                 315                 320 
Ile Pro Gln Asn Gln Val Asn Arg Lys Ser Asp Ile Tyr Val Cys Met
                325                 330                 335     
Ile Ser Phe Ala His Asn Val Ala Ala Gln Gly Lys Tyr Ile Ala Ile
            340                 345                 350         
Val Ser Thr Thr Val Glu Thr Lys Glu Pro Glu Lys Glu Ile Arg Pro
        355                 360                 365             
Ala Leu Glu Leu Leu Glu Pro Ile Glu Gln Lys Phe Val Ser Ile Ser
    370                 375                 380                 
Asp Leu Leu Val Pro Lys Asp Leu Gly Thr Glu Ser Gln Ile Phe Ile
385                 390                 395                 400 
Ser Arg Thr Tyr Asp Ala Thr Thr His Phe Glu Thr Thr Cys Asp Asp
                405                 410                 415     
Ile Lys Asn Ile Tyr Lys Arg Met Thr Gly Ser Glu Phe Asp Phe Glu
            420                 425                 430         
Glu Met Lys Arg Lys Lys Asn Asp Ile Tyr Gly Glu Asp
        435                 440                 445 


<210> 95
<211> 143
<212> PRT
<213> Homo sapiens

<400> 95
Cys Phe Val Leu Phe Val Lys Leu Phe Pro Gly Leu Phe Leu Gln His
 1               5                  10                  15      
Leu Phe Leu Ser Leu Thr Asp Ser Phe His Ala Lys Val Thr Gln Thr
            20                  25                  30          
Pro Gly His Leu Val Lys Gly Lys Gly Gln Lys Thr Lys Met Asp Cys
        35                  40                  45              
Thr Pro Glu Lys Gly His Thr Phe Val Tyr Trp Tyr Gln Gln Asn Gln
    50                  55                  60                  
Asn Lys Glu Phe Met Leu Leu Ile Ser Phe Gln Asn Glu Gln Val Leu
65                  70                  75                  80  
Gln Glu Thr Glu Met His Lys Lys Arg Phe Ser Ser Gln Cys Pro Lys
                85                  90                  95      
Asn Ala Pro Cys Ser Leu Ala Ile Leu Ser Ser Glu Pro Gly Asp Thr
            100                 105                 110         
Ala Leu Tyr Leu Cys Ala Ser Ser Leu Gly Gln Gly Glu Ser Pro Leu
        115                 120                 125             
His Phe Gly Asn Gly Thr Arg Leu Thr Val Thr Glu Asp Leu Asn
    130                 135                 140             


<210> 96
<211> 328
<212> PRT
<213> Homo sapiens

<400> 96
Met Leu Pro Arg Val Gly Cys Pro Ala Leu Pro Leu Pro Pro Pro Pro
 1               5                  10                  15      
Leu Leu Pro Leu Leu Pro Leu Leu Leu Leu Leu Leu Gly Ala Ser Gly
            20                  25                  30          
Gly Gly Gly Gly Ala Arg Ala Glu Val Leu Phe Arg Cys Pro Pro Cys
        35                  40                  45              
Thr Pro Glu Arg Leu Ala Ala Cys Gly Pro Pro Arg Val Ala Pro Pro
    50                  55                  60                  
Ala Ala Val Ala Ala Val Ala Gly Gly Ala Arg Met Pro Cys Ala Glu
65                  70                  75                  80  
Leu Val Arg Glu Pro Gly Cys Gly Cys Cys Ser Val Cys Ala Arg Leu
                85                  90                  95      
Glu Gly Glu Ala Cys Gly Val Tyr Thr Pro Arg Cys Gly Gln Gly Leu
            100                 105                 110         
Arg Cys Tyr Pro His Pro Gly Ser Glu Leu Pro Leu Gln Ala Leu Val
        115                 120                 125             
Met Gly Glu Gly Thr Cys Glu Lys Arg Arg Asp Ala Glu Tyr Gly Ala
    130                 135                 140                 
Ser Pro Glu Gln Val Ala Asp Asn Gly Asp Asp His Ser Glu Gly Gly
145                 150                 155                 160 
Leu Val Glu Asn His Val Asp Ser Thr Met Asn Met Leu Gly Gly Gly
                165                 170                 175     
Gly Ser Ala Gly Arg Lys Pro Leu Lys Ser Gly Met Lys Glu Leu Ala
            180                 185                 190         
Val Phe Arg Glu Lys Val Thr Glu Gln His Arg Gln Met Gly Lys Gly
        195                 200                 205             
Gly Lys His His Leu Gly Leu Glu Glu Pro Lys Lys Leu Arg Pro Pro
    210                 215                 220                 
Pro Ala Arg Thr Pro Cys Gln Gln Glu Leu Asp Gln Val Leu Glu Arg
225                 230                 235                 240 
Ile Ser Thr Met Arg Leu Pro Asp Glu Arg Gly Pro Leu Glu His Leu
                245                 250                 255     
Tyr Ser Leu His Ile Pro Asn Cys Asp Lys His Gly Leu Tyr Asn Leu
            260                 265                 270         
Lys Gln Cys Lys Met Ser Leu Asn Gly Gln Arg Gly Glu Cys Trp Cys
        275                 280                 285             
Val Asn Pro Asn Thr Gly Lys Leu Ile Gln Gly Ala Pro Thr Ile Arg
    290                 295                 300                 
Gly Asp Pro Glu Cys His Leu Phe Tyr Asn Glu Gln Gln Glu Ala Arg
305                 310                 315                 320 
Gly Val Asp Thr Gln Arg Met Gln
                325             


<210> 97
<211> 123
<212> PRT
<213> Homo sapiens

<400> 97
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Thr Tyr
            20                  25                  30          
Ala Phe Ser Trp Val Arg His Ser Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Gly Ile Thr Pro Met Phe Gly Thr Ala Arg Tyr Ala Gln Asn Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Arg Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Trp Leu Asp Pro Ser Met Ala Thr Thr Pro Phe Gly Phe
            100                 105                 110         
Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser
        115                 120             


<210> 98
<211> 364
<212> PRT
<213> Homo sapiens

<400> 98
Met Pro His Ser Tyr Pro Ala Leu Ser Ala Glu Gln Lys Lys Glu Leu
 1               5                  10                  15      
Ser Asp Ile Ala Leu Arg Ile Val Ala Pro Gly Lys Gly Ile Leu Ala
            20                  25                  30          
Ala Asp Glu Ser Val Gly Ser Met Ala Lys Arg Leu Ser Gln Ile Gly
        35                  40                  45              
Val Glu Asn Thr Glu Glu Asn Arg Arg Leu Tyr Arg Gln Val Leu Phe
    50                  55                  60                  
Ser Ala Asp Asp Arg Val Lys Lys Cys Ile Gly Gly Val Ile Phe Phe
65                  70                  75                  80  
His Glu Thr Leu Tyr Gln Lys Asp Asp Asn Gly Val Pro Phe Val Arg
                85                  90                  95      
Thr Ile Gln Asp Lys Gly Ile Val Val Gly Ile Lys Val Asp Lys Gly
            100                 105                 110         
Val Val Pro Leu Ala Gly Thr Asp Gly Glu Thr Thr Thr Gln Gly Leu
        115                 120                 125             
Asp Gly Leu Ser Glu Arg Cys Ala Gln Tyr Lys Lys Asp Gly Ala Asp
    130                 135                 140                 
Phe Ala Lys Trp Arg Cys Val Leu Lys Ile Ser Glu Arg Thr Pro Ser
145                 150                 155                 160 
Ala Leu Ala Ile Leu Glu Asn Ala Asn Val Leu Ala Arg Tyr Ala Ser
                165                 170                 175     
Ile Cys Gln Gln Asn Gly Ile Val Pro Ile Val Glu Pro Glu Ile Leu
            180                 185                 190         
Pro Asp Gly Asp His Asp Leu Lys Arg Cys Gln Tyr Val Thr Glu Lys
        195                 200                 205             
Val Leu Ala Ala Val Tyr Lys Ala Leu Ser Asp His His Val Tyr Leu
    210                 215                 220                 
Glu Gly Thr Leu Leu Lys Pro Asn Met Val Thr Pro Gly His Ala Cys
225                 230                 235                 240 
Pro Ile Lys Tyr Thr Pro Glu Glu Ile Ala Met Ala Thr Val Thr Ala
                245                 250                 255     
Leu Arg Arg Thr Val Pro Pro Ala Val Pro Gly Val Thr Phe Leu Ser
            260                 265                 270         
Gly Gly Gln Ser Glu Glu Glu Ala Ser Phe Asn Leu Asn Ala Ile Asn
        275                 280                 285             
Arg Cys Pro Leu Pro Arg Pro Trp Ala Leu Thr Phe Ser Tyr Gly Arg
    290                 295                 300                 
Ala Leu Gln Ala Ser Ala Val Asn Ala Trp Arg Gly Gln Arg Asp Asn
305                 310                 315                 320 
Ala Gly Ala Ala Thr Glu Glu Phe Ile Lys Arg Ala Glu Val Asn Gly
                325                 330                 335     
Leu Ala Ala Gln Gly Lys Tyr Glu Gly Ser Gly Glu Asp Gly Gly Ala
            340                 345                 350         
Ala Ala Gln Ser Leu Tyr Ile Ala Asn His Ala Tyr
        355                 360                 


<210> 99
<211> 223
<212> PRT
<213> Homo sapiens

<400> 99
Met Asn Lys Pro Leu Leu Trp Ile Ser Val Leu Thr Ser Leu Leu Glu
 1               5                  10                  15      
Ala Phe Ala His Thr Asp Leu Ser Gly Lys Val Phe Val Phe Pro Arg
            20                  25                  30          
Glu Ser Val Thr Asp His Val Asn Leu Ile Thr Pro Leu Glu Lys Pro
        35                  40                  45              
Leu Gln Asn Phe Thr Leu Cys Phe Arg Ala Tyr Ser Asp Leu Ser Arg
    50                  55                  60                  
Ala Tyr Ser Leu Phe Ser Tyr Asn Thr Gln Gly Arg Asp Asn Glu Leu
65                  70                  75                  80  
Leu Val Tyr Lys Glu Arg Val Gly Glu Tyr Ser Leu Tyr Ile Gly Arg
                85                  90                  95      
His Lys Val Thr Pro Lys Val Ile Glu Lys Phe Pro Ala Pro Val His
            100                 105                 110         
Ile Cys Val Ser Trp Glu Ser Ser Ser Gly Ile Ala Glu Phe Trp Ile
        115                 120                 125             
Asn Gly Thr Pro Leu Val Lys Lys Gly Leu Arg Gln Gly Tyr Phe Val
    130                 135                 140                 
Glu Ala Gln Pro Lys Ile Val Leu Gly Gln Glu Gln Asp Ser Tyr Gly
145                 150                 155                 160 
Gly Lys Phe Asp Arg Ser Gln Ser Phe Val Gly Glu Ile Gly Asp Leu
                165                 170                 175     
Tyr Met Trp Asp Ser Val Leu Pro Pro Glu Asn Ile Leu Ser Ala Tyr
            180                 185                 190         
Gln Gly Thr Pro Leu Pro Ala Asn Ile Leu Asp Trp Gln Ala Leu Asn
        195                 200                 205             
Tyr Glu Ile Arg Gly Tyr Val Ile Ile Lys Pro Leu Val Trp Val
    210                 215                 220             


<210> 100
<211> 40
<212> PRT
<213> Homo sapiens

<400> 100
Pro Phe Ser Val Cys Gly Glu Tyr Phe Pro Arg Val Lys Leu Lys Leu
 1               5                  10                  15      
Ile Phe Phe Phe Ser Lys His Lys Gln Ser Leu Leu Gly Gly Asp Met
            20                  25                  30          
Asp Met Gly Asn Pro Gly Thr Leu
        35                  40  


<210> 101
<211> 508
<212> PRT
<213> Homo sapiens

<400> 101
Met Leu Arg Arg Ala Leu Leu Cys Leu Ala Val Ala Ala Leu Val Arg
 1               5                  10                  15      
Ala Asp Ala Pro Glu Glu Glu Asp His Val Leu Val Leu Arg Lys Ser
            20                  25                  30          
Asn Phe Ala Glu Ala Leu Ala Ala His Lys Tyr Leu Leu Val Glu Phe
        35                  40                  45              
Tyr Ala Pro Trp Cys Gly His Cys Lys Ala Leu Ala Pro Glu Tyr Ala
    50                  55                  60                  
Lys Ala Ala Gly Lys Leu Lys Ala Glu Gly Ser Glu Ile Arg Leu Ala
65                  70                  75                  80  
Lys Val Asp Ala Thr Glu Glu Ser Asp Leu Ala Gln Gln Tyr Gly Val
                85                  90                  95      
Arg Gly Tyr Pro Thr Ile Lys Phe Phe Arg Asn Gly Asp Thr Ala Ser
            100                 105                 110         
Pro Lys Glu Tyr Thr Ala Gly Arg Glu Ala Asp Asp Ile Val Asn Trp
        115                 120                 125             
Leu Lys Lys Arg Thr Gly Pro Ala Ala Thr Thr Leu Arg Asp Gly Ala
    130                 135                 140                 
Ala Ala Glu Ser Leu Val Glu Ser Ser Glu Val Ala Val Ile Gly Phe
145                 150                 155                 160 
Phe Lys Asp Val Glu Ser Asp Ser Ala Lys Gln Phe Leu Gln Ala Ala
                165                 170                 175     
Glu Ala Ile Asp Asp Ile Pro Phe Gly Ile Thr Ser Asn Ser Asp Val
            180                 185                 190         
Phe Ser Lys Tyr Gln Leu Asp Lys Asp Gly Val Val Leu Phe Lys Lys
        195                 200                 205             
Phe Asp Glu Gly Arg Asn Asn Phe Glu Gly Glu Val Thr Lys Glu Asn
    210                 215                 220                 
Leu Leu Asp Phe Ile Lys His Asn Gln Leu Pro Leu Val Ile Glu Phe
225                 230                 235                 240 
Thr Glu Gln Thr Ala Pro Lys Ile Phe Gly Gly Glu Ile Lys Thr His
                245                 250                 255     
Ile Leu Leu Phe Leu Pro Lys Ser Val Ser Asp Tyr Asp Gly Lys Leu
            260                 265                 270         
Ser Asn Phe Lys Thr Ala Ala Glu Ser Phe Lys Gly Lys Ile Leu Phe
        275                 280                 285             
Ile Phe Ile Asp Ser Asp His Thr Asp Asn Gln Arg Ile Leu Glu Phe
    290                 295                 300                 
Phe Gly Leu Lys Lys Glu Glu Cys Pro Ala Val Arg Leu Ile Thr Leu
305                 310                 315                 320 
Glu Glu Glu Met Thr Lys Tyr Lys Pro Glu Ser Glu Glu Leu Thr Ala
                325                 330                 335     
Glu Arg Ile Thr Glu Phe Cys His Arg Phe Leu Glu Gly Lys Ile Lys
            340                 345                 350         
Pro His Leu Met Ser Gln Glu Arg Ala Gly Asp Trp Asp Lys Gln Pro
        355                 360                 365             
Val Lys Val Pro Val Gly Lys Asn Phe Glu Asp Val Ala Phe Asp Glu
    370                 375                 380                 
Lys Lys Asn Val Phe Val Glu Phe Tyr Ala Pro Trp Cys Gly His Cys
385                 390                 395                 400 
Lys Gln Leu Ala Pro Ile Trp Asp Lys Leu Gly Glu Thr Tyr Lys Asp
                405                 410                 415     
His Glu Asn Ile Val Ile Ala Lys Met Asp Ser Thr Ala Asn Glu Val
            420                 425                 430         
Glu Ala Val Lys Val His Ser Phe Pro Thr Leu Lys Phe Phe Pro Ala
        435                 440                 445             
Ser Ala Asp Arg Thr Val Ile Asp Tyr Asn Gly Glu Arg Thr Leu Asp
    450                 455                 460                 
Gly Phe Lys Lys Phe Leu Glu Ser Gly Gly Gln Asp Gly Ala Gly Asp
465                 470                 475                 480 
Asp Asp Asp Leu Glu Asp Leu Glu Glu Ala Glu Glu Pro Asp Met Glu
                485                 490                 495     
Glu Asp Asp Asp Gln Lys Ala Val Lys Asp Glu Leu
            500                 505             


<210> 102
<211> 725
<212> PRT
<213> Homo sapiens

<400> 102
Arg Lys Ser Tyr Tyr Ser Lys Asp Pro Ser Arg Ala Glu Lys Arg Glu
 1               5                  10                  15      
Ile Lys Cys Pro Thr Pro Gly Cys Asp Gly Thr Gly His Val Thr Gly
            20                  25                  30          
Leu Tyr Pro His His Arg Ser Leu Ser Gly Cys Pro His Lys Asp Arg
        35                  40                  45              
Ile Pro Pro Glu Ile Leu Ala Met His Glu Asn Val Leu Lys Cys Pro
    50                  55                  60                  
Thr Pro Gly Cys Thr Gly Gln Gly His Val Asn Ser Asn Arg Asn Thr
65                  70                  75                  80  
His Arg Ser Leu Ser Gly Cys Pro Ile Ala Ala Ala Glu Lys Leu Ala
                85                  90                  95      
Lys Ser His Glu Lys Gln Gln Pro Gln Thr Gly Asp Pro Ser Lys Ser
            100                 105                 110         
Ser Ser Asn Ser Asp Arg Ile Leu Arg Pro Met Cys Phe Val Lys Gln
        115                 120                 125             
Leu Glu Val Pro Pro Tyr Gly Ser Tyr Arg Pro Asn Val Ala Pro Arg
    130                 135                 140                 
His Thr Gln Gly Gln Leu Gly Lys Glu Leu Glu Lys Phe Ser Lys Val
145                 150                 155                 160 
Thr Phe Asp Tyr Ala Ser Phe Asp Ala Gln Val Phe Gly Lys Arg Met
                165                 170                 175     
Leu Ala Pro Lys Ile Gln Thr Ser Glu Thr Ser Pro Lys Ala Phe Gln
            180                 185                 190         
Ser Lys Pro Phe Pro Lys Ala Ser Ser Pro Arg His Ser Pro Ser Ser
        195                 200                 205             
Ser Tyr Val Arg Ser Thr Ser Ser Ser Ser Ala Gly Phe Asp Tyr Ser
    210                 215                 220                 
Gln Asp Ala Glu Ala Ala His Met Ala Ala Thr Ala Ile Leu Asn Leu
225                 230                 235                 240 
Ser Thr Arg Cys Trp Glu Met Pro Glu Asn Leu Ser Thr Lys Pro Gln
                245                 250                 255     
Asp Leu Pro Ser Lys Ser Val Asp Ile Glu Val Asp Glu Asn Gly Thr
            260                 265                 270         
Leu Asp Leu Ser Met His Lys His Arg Lys Arg Glu Asn Ala Phe Pro
        275                 280                 285             
Ser Ser Ser Ser Cys Ser Ser Ser Pro Gly Val Lys Ser Pro Asp Ala
    290                 295                 300                 
Ser Gln Arg His Ser Ser Thr Ser Ala Pro Ser Ser Ser Met Thr Ser
305                 310                 315                 320 
Pro Gln Ser Ser Gln Ala Ser Arg Gln Asp Glu Trp Asp Arg Pro Leu
                325                 330                 335     
Asp Tyr Thr Lys Pro Ser Arg Leu Arg Glu Glu Glu Pro Glu Glu Ser
            340                 345                 350         
Glu Pro Ala Ala His Ser Phe Ala Ser Ser Glu Ala Asp Asp Gln Glu
        355                 360                 365             
Val Ser Glu Glu Asn Phe Glu Glu Arg Lys Tyr Pro Gly Glu Val Thr
    370                 375                 380                 
Leu Thr Asn Phe Lys Leu Lys Phe Leu Ser Lys Asp Ile Lys Lys Glu
385                 390                 395                 400 
Leu Leu Thr Cys Pro Thr Pro Gly Cys Asp Gly Ser Gly His Ile Thr
                405                 410                 415     
Gly Asn Tyr Ala Ser His Arg Ser Leu Ser Gly Cys Pro Leu Ala Asp
            420                 425                 430         
Lys Ser Leu Arg Asn Leu Met Ala Thr His Ser Ala Asp Leu Lys Cys
        435                 440                 445             
Pro Thr Pro Gly Cys Asp Gly Ser Gly His Ile Thr Gly Asn Tyr Ala
    450                 455                 460                 
Ser His Arg Ser Leu Ser Gly Cys Pro Arg Ala Lys Lys Ser Gly Val
465                 470                 475                 480 
Lys Val Ala Pro Thr Lys Asp Asp Lys Glu Asp Pro Glu Leu Met Lys
                485                 490                 495     
Cys Pro Val Pro Gly Cys Val Gly Leu Gly His Ile Ser Gly Lys Tyr
            500                 505                 510         
Ala Ser His Arg Ser Ala Ser Gly Cys Pro Leu Ala Ala Arg Arg Gln
        515                 520                 525             
Lys Glu Gly Ser Leu Asn Gly Ser Ser Phe Ser Trp Lys Ser Leu Lys
    530                 535                 540                 
Asn Glu Asp Pro Thr Cys Pro Thr Pro Gly Cys Asp Gly Ser Gly His
545                 550                 555                 560 
Thr Ile Gly Ser Phe Leu Thr His Arg Ser Leu Ser Gly Cys Pro Arg
                565                 570                 575     
Ala Thr Phe Ala Gly Lys Lys Gly Lys Leu Ser Gly Asp Glu Val Leu
            580                 585                 590         
Ser Pro Lys Phe Lys Thr Ser Asp Val Leu Glu Asn Asp Glu Glu Ile
        595                 600                 605             
Lys Gln Leu Asn Gln Glu Ile Arg Asp Leu Asn Glu Ser Asn Ser Glu
    610                 615                 620                 
Met Glu Ala Ala Met Val Gln Leu Gln Ser Gln Ile Ser Ser Met Glu
625                 630                 635                 640 
Lys Asn Leu Lys Asn Ile Glu Glu Glu Asn Lys Leu Ile Glu Glu Gln
                645                 650                 655     
Asn Glu Ala Leu Phe Leu Glu Leu Ser Gly Leu Ser Gln Ala Leu Ile
            660                 665                 670         
Gln Ser Leu Ala Asn Ile His Leu Pro His Met Glu Pro Ile Cys Glu
        675                 680                 685             
Gln Asn Phe Val Pro Tyr Val Ser Thr Leu Thr Asp Met Tyr Ser Asn
    690                 695                 700                 
Gln Ala Pro Glu Asn Lys Asp Leu Leu Glu Ser Ile Lys Gln Ala Val
705                 710                 715                 720 
Arg Gly Ile Gln Val
                725 


<210> 103
<211> 275
<212> PRT
<213> Homo sapiens

<400> 103
Phe Gln Arg Ser Thr Pro Ala Ile Thr Leu Glu Ser Pro Asp Ile Lys
 1               5                  10                  15      
Tyr Pro Leu Arg Leu Ile Asp Arg Glu Ile Ile Ser His Asp Thr Arg
            20                  25                  30          
Arg Phe Arg Phe Ala Leu Pro Ser Pro Gln His Ile Leu Gly Leu Pro
        35                  40                  45              
Val Gly Gln His Ile Tyr Leu Ser Ala Arg Ile Asp Gly Asn Leu Val
    50                  55                  60                  
Val Arg Pro Tyr Thr Pro Ile Ser Ser Asp Asp Asp Lys Gly Phe Val
65                  70                  75                  80  
Asp Leu Val Ile Lys Val Tyr Phe Lys Asp Thr His Pro Lys Phe Pro
                85                  90                  95      
Ala Gly Gly Lys Met Ser Gln Tyr Leu Glu Ser Met Gln Ile Gly Asp
            100                 105                 110         
Thr Ile Glu Phe Arg Gly Pro Ser Gly Leu Leu Val Tyr Gln Gly Lys
        115                 120                 125             
Gly Lys Phe Ala Ile Arg Pro Asp Lys Lys Ser Asn Pro Ile Ile Arg
    130                 135                 140                 
Thr Val Lys Ser Val Gly Met Ile Ala Gly Gly Thr Gly Ile Thr Pro
145                 150                 155                 160 
Met Leu Gln Val Ile Arg Ala Ile Met Lys Asp Pro Asp Asp His Thr
                165                 170                 175     
Val Cys His Leu Leu Phe Ala Asn Gln Thr Glu Lys Asp Ile Leu Leu
            180                 185                 190         
Arg Pro Glu Leu Glu Glu Leu Arg Asn Lys His Ser Ala Arg Phe Lys
        195                 200                 205             
Leu Trp Tyr Thr Leu Asp Arg Ala Pro Glu Ala Trp Asp Tyr Gly Gln
    210                 215                 220                 
Gly Phe Val Asn Glu Glu Met Ile Arg Asp His Leu Pro Pro Pro Glu
225                 230                 235                 240 
Glu Glu Pro Leu Val Leu Met Cys Gly Pro Pro Pro Met Ile Gln Tyr
                245                 250                 255     
Ala Cys Leu Pro Asn Leu Asp His Val Gly His Pro Thr Glu Arg Cys
            260                 265                 270         
Phe Val Phe
        275 


<210> 104
<211> 101
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = Any Amino Acid

<400> 104
Val Gly Ile Tyr Xaa Gly Thr His Val Ile Pro Asn Asp Arg Lys Ile
 1               5                  10                  15      
Ile Trp Pro Gly Gly Glu Thr Glu Lys Ser Arg Gly Tyr Gln Met Ser
            20                  25                  30          
Thr Arg Leu Lys Ile Val Thr Ile His Gln Glu Pro Phe Val Tyr Val
        35                  40                  45              
Lys Pro Thr Leu Ser Asp Gly Thr Cys Lys Glu Glu Phe Thr Val Asn
    50                  55                  60                  
Gly Asp Pro Val Lys Lys Val Ile Cys Thr Gly Pro Asn Asp Thr Ser
65                  70                  75                  80  
Pro Gly Ser Pro Arg His Thr Val Pro Gln Cys Cys Tyr Gly Phe Cys
                85                  90                  95      
Ile Asp Leu Leu Ile
            100     


<210> 105
<211> 379
<212> PRT
<213> Homo sapiens

<400> 105
Met Gly Cys Leu Gly Asn Ser Lys Thr Glu Asp Gln Arg Asn Glu Glu
 1               5                  10                  15      
Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu Gln Lys
            20                  25                  30          
Asp Lys Gln Val Tyr Arg Ala Thr His Arg Leu Leu Leu Leu Gly Ala
        35                  40                  45              
Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile Leu His
    50                  55                  60                  
Val Asn Gly Phe Asn Gly Asp Glu Lys Ala Thr Lys Val Gln Asp Ile
65                  70                  75                  80  
Lys Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val Ala Ala Met Ser
                85                  90                  95      
Asn Leu Val Pro Pro Val Glu Leu Ala Asn Pro Glu Asn Gln Phe Arg
            100                 105                 110         
Val Asp Tyr Ile Leu Ser Val Met Asn Val Pro Asp Phe Asp Phe Pro
        115                 120                 125             
Pro Glu Phe Tyr Glu His Ala Lys Ala Leu Trp Glu Asp Glu Gly Val
    130                 135                 140                 
Arg Ala Cys Tyr Glu Arg Ser Asn Glu Tyr Gln Leu Ile Asp Cys Ala
145                 150                 155                 160 
Gln Tyr Phe Leu Asp Lys Ile Asp Val Ile Lys Gln Ala Asp Tyr Val
                165                 170                 175     
Pro Ser Asp Gln Asp Leu Leu Arg Cys Arg Val Leu Thr Ser Gly Ile
            180                 185                 190         
Phe Glu Thr Lys Phe Gln Val Asp Lys Val Asn Phe His Met Phe Asp
        195                 200                 205             
Val Gly Gly Gln Arg Asp Glu Arg Arg Lys Trp Ile Gln Cys Phe Asn
    210                 215                 220                 
Asp Val Thr Ala Ile Ile Phe Val Val Ala Ser Ser Ser Tyr Asn Met
225                 230                 235                 240 
Val Ile Arg Glu Asp Asn Gln Thr Asn Arg Leu Gln Glu Ala Leu Asn
                245                 250                 255     
Leu Phe Lys Ser Ile Trp Asn Asn Arg Trp Leu Arg Thr Ile Ser Val
            260                 265                 270         
Ile Leu Phe Leu Asn Lys Gln Asp Leu Leu Ala Glu Lys Val Leu Ala
        275                 280                 285             
Gly Lys Ser Lys Ile Glu Asp Tyr Phe Pro Glu Phe Ala Arg Tyr Thr
    290                 295                 300                 
Thr Pro Glu Asp Ala Thr Pro Glu Pro Gly Glu Asp Pro Arg Val Thr
305                 310                 315                 320 
Arg Ala Lys Tyr Phe Ile Arg Asp Glu Phe Leu Arg Ile Ser Thr Ala
                325                 330                 335     
Ser Gly Asp Gly Arg His Tyr Cys Tyr Pro His Phe Thr Cys Ala Val
            340                 345                 350         
Asp Thr Glu Asn Ile Arg Arg Val Phe Asn Asp Cys Arg Asp Ile Ile
        355                 360                 365             
Gln Arg Met His Leu Arg Gln Tyr Glu Leu Leu
    370                 375                 


<210> 106
<211> 154
<212> PRT
<213> Homo sapiens

<400> 106
Met Gly Leu Ser Asp Gly Glu Trp Gln Leu Val Leu Asn Val Trp Gly
 1               5                  10                  15      
Lys Val Glu Ala Asp Ile Pro Gly His Gly Gln Glu Val Leu Ile Arg
            20                  25                  30          
Leu Phe Lys Gly His Pro Glu Thr Leu Glu Lys Phe Asp Lys Phe Lys
        35                  40                  45              
His Leu Lys Ser Glu Asp Glu Met Lys Ala Ser Glu Asp Leu Lys Lys
    50                  55                  60                  
His Gly Ala Thr Val Leu Thr Ala Leu Gly Gly Ile Leu Lys Lys Lys
65                  70                  75                  80  
Gly His His Glu Ala Glu Ile Lys Pro Leu Ala Gln Ser His Ala Thr
                85                  90                  95      
Lys His Lys Ile Pro Val Lys Tyr Leu Glu Phe Ile Ser Glu Cys Ile
            100                 105                 110         
Ile Gln Val Leu Gln Ser Lys His Pro Gly Asp Phe Gly Ala Asp Ala
        115                 120                 125             
Glu Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Met Ala
    130                 135                 140                 
Ser Asn Tyr Lys Glu Leu Gly Phe Gln Gly
145                 150                 


<210> 107
<211> 335
<212> PRT
<213> Homo sapiens

<400> 107
Trp Thr Ala Pro Ala Ala Val Gln Val Thr Val Arg Asp Ala Ile Asn
 1               5                  10                  15      
Gln Gly Met Asp Glu Glu Leu Glu Arg Asp Glu Lys Val Phe Leu Leu
            20                  25                  30          
Gly Glu Glu Val Ala Gln Tyr Asp Gly Ala Tyr Lys Val Ser Arg Gly
        35                  40                  45              
Leu Trp Lys Lys Tyr Gly Asp Lys Arg Ile Ile Asp Thr Pro Ile Ser
    50                  55                  60                  
Glu Met Gly Phe Ala Gly Ile Ala Val Gly Ala Ala Met Ala Gly Leu
65                  70                  75                  80  
Arg Pro Ile Cys Glu Phe Met Thr Phe Asn Phe Ser Met Gln Ala Ile
                85                  90                  95      
Asp Gln Val Ile Asn Ser Ala Ala Lys Thr Tyr Tyr Met Ser Gly Gly
            100                 105                 110         
Leu Gln Pro Val Pro Ile Val Phe Arg Gly Pro Asn Gly Ala Ser Ala
        115                 120                 125             
Gly Val Ala Ala Gln His Ser Gln Cys Phe Ala Ala Trp Tyr Gly His
    130                 135                 140                 
Cys Pro Gly Leu Lys Val Val Ser Pro Trp Asn Ser Glu Asp Ala Lys
145                 150                 155                 160 
Gly Leu Ile Lys Ser Ala Ile Arg Asp Asn Asn Pro Val Val Val Leu
                165                 170                 175     
Glu Asn Glu Leu Met Tyr Gly Val Pro Phe Glu Phe Pro Pro Glu Ala
            180                 185                 190         
Gln Ser Lys Asp Phe Leu Ile Pro Ile Gly Lys Ala Lys Ile Glu Arg
        195                 200                 205             
Gln Gly Thr His Ile Thr Val Val Ser His Ser Arg Pro Val Gly His
    210                 215                 220                 
Cys Leu Glu Ala Ala Ala Val Leu Ser Lys Glu Gly Val Glu Cys Glu
225                 230                 235                 240 
Val Ile Asn Met Arg Thr Ile Arg Pro Met Asp Met Glu Thr Ile Glu
                245                 250                 255     
Ala Ser Val Met Lys Thr Asn His Leu Val Thr Val Glu Gly Gly Trp
            260                 265                 270         
Pro Gln Phe Gly Val Gly Ala Glu Ile Cys Ala Arg Ile Met Glu Gly
        275                 280                 285             
Pro Ala Phe Asn Phe Leu Asp Ala Pro Ala Val Arg Val Thr Gly Ala
    290                 295                 300                 
Asp Val Pro Met Pro Tyr Ala Lys Ile Leu Glu Asp Asn Ser Ile Pro
305                 310                 315                 320 
Gln Val Lys Asp Ile Ile Phe Ala Ile Lys Lys Thr Leu Asn Ile
                325                 330                 335 


<210> 108
<211> 414
<212> PRT
<213> Homo sapiens

<400> 108
Glu Thr Trp Gly His Pro Arg Arg Ala Ser Trp Val Val Arg Ser Arg
 1               5                  10                  15      
Arg Cys Arg His Cys Leu Cys Phe Met Arg Lys Met Leu Ala Ala Val
            20                  25                  30          
Ser Arg Val Leu Ser Gly Ala Ser Gln Lys Pro Ala Ser Arg Val Leu
        35                  40                  45              
Val Ala Ser Arg Asn Phe Ala Asn Asp Ala Thr Phe Glu Ile Lys Lys
    50                  55                  60                  
Cys Asp Leu His Arg Leu Glu Glu Gly Pro Pro Val Thr Thr Val Leu
65                  70                  75                  80  
Thr Arg Glu Asp Gly Leu Lys Tyr Tyr Arg Met Met Gln Thr Val Arg
                85                  90                  95      
Arg Met Glu Leu Lys Ala Asp Gln Leu Tyr Lys Gln Lys Ile Ile Arg
            100                 105                 110         
Gly Phe Cys His Leu Cys Asp Gly Gln Glu Ala Cys Cys Val Gly Leu
        115                 120                 125             
Glu Ala Gly Ile Asn Pro Thr Asp His Leu Ile Thr Ala Tyr Arg Ala
    130                 135                 140                 
His Gly Phe Thr Phe Thr Arg Gly Leu Ser Val Arg Glu Ile Leu Ala
145                 150                 155                 160 
Glu Leu Thr Gly Arg Lys Gly Gly Cys Ala Lys Gly Lys Gly Gly Ser
                165                 170                 175     
Met His Met Tyr Ala Lys Asn Phe Tyr Gly Gly Asn Gly Ile Val Gly
            180                 185                 190         
Ala Gln Val Pro Leu Gly Ala Gly Ile Ala Leu Ala Cys Lys Tyr Asn
        195                 200                 205             
Gly Lys Asp Glu Val Cys Leu Thr Leu Tyr Gly Asp Gly Ala Ala Asn
    210                 215                 220                 
Gln Gly Gln Ile Phe Glu Ala Tyr Asn Met Ala Ala Leu Trp Lys Leu
225                 230                 235                 240 
Pro Cys Ile Phe Ile Cys Glu Asn Asn Arg Tyr Gly Met Gly Thr Ser
                245                 250                 255     
Val Glu Arg Ala Ala Ala Ser Thr Asp Tyr Tyr Lys Arg Gly Asp Phe
            260                 265                 270         
Ile Pro Gly Leu Arg Val Asp Gly Met Asp Ile Leu Cys Val Arg Glu
        275                 280                 285             
Ala Thr Arg Phe Ala Ala Ala Tyr Cys Arg Ser Gly Lys Gly Pro Ile
    290                 295                 300                 
Leu Met Glu Leu Gln Thr Tyr Arg Tyr His Gly His Ser Met Ser Asp
305                 310                 315                 320 
Pro Gly Val Ser Tyr Arg Thr Arg Glu Glu Ile Gln Glu Val Arg Ser
                325                 330                 335     
Lys Ser Asp Pro Ile Met Leu Leu Lys Asp Arg Met Val Asn Ser Asn
            340                 345                 350         
Leu Ala Ser Val Glu Glu Leu Lys Glu Ile Asp Val Glu Val Arg Lys
        355                 360                 365             
Glu Ile Glu Asp Pro Ala Gln Phe Ala Ala Ala Asp Pro Glu Pro Pro
    370                 375                 380                 
Leu Glu Glu Leu Gly Tyr His Ile Tyr Ser Ser Asp Pro Pro Phe Glu
385                 390                 395                 400 
Val Arg Gly Ala Asn Gln Trp Ile Lys Phe Lys Ser Val Ser
                405                 410                 


<210> 109
<211> 414
<212> PRT
<213> Homo sapiens

<400> 109
Glu Thr Trp Gly His Pro Arg Arg Ala Ser Trp Val Val Arg Ser Arg
 1               5                  10                  15      
Arg Cys Arg His Cys Leu Cys Phe Met Arg Lys Met Leu Ala Ala Val
            20                  25                  30          
Ser Arg Val Leu Ser Gly Ala Ser Gln Lys Pro Ala Ser Arg Val Leu
        35                  40                  45              
Val Ala Ser Arg Asn Phe Ala Asn Asp Ala Thr Phe Glu Ile Lys Lys
    50                  55                  60                  
Cys Asp Leu His Arg Leu Glu Glu Gly Pro Pro Val Thr Thr Val Leu
65                  70                  75                  80  
Thr Arg Glu Asp Gly Leu Lys Tyr Tyr Arg Met Met Gln Thr Val Arg
                85                  90                  95      
Arg Met Glu Leu Lys Ala Asp Gln Leu Tyr Lys Gln Lys Ile Ile Arg
            100                 105                 110         
Gly Phe Cys His Leu Cys Asp Gly Gln Glu Ala Cys Cys Val Gly Leu
        115                 120                 125             
Glu Ala Gly Ile Asn Pro Thr Asp His Leu Ile Thr Ala Tyr Arg Ala
    130                 135                 140                 
His Gly Phe Thr Phe Thr Arg Gly Leu Ser Val Arg Glu Ile Leu Ala
145                 150                 155                 160 
Glu Leu Thr Gly Arg Lys Gly Gly Cys Ala Lys Gly Lys Gly Gly Ser
                165                 170                 175     
Met His Met Tyr Ala Lys Asn Phe Tyr Gly Gly Asn Gly Ile Val Gly
            180                 185                 190         
Ala Gln Val Pro Leu Gly Ala Gly Ile Ala Leu Ala Cys Lys Tyr Asn
        195                 200                 205             
Gly Lys Asp Glu Val Cys Leu Thr Leu Tyr Gly Asp Gly Ala Ala Asn
    210                 215                 220                 
Gln Gly Gln Ile Phe Glu Ala Tyr Asn Met Ala Ala Leu Trp Lys Leu
225                 230                 235                 240 
Pro Cys Ile Phe Ile Cys Glu Asn Asn Arg Tyr Gly Met Gly Thr Ser
                245                 250                 255     
Val Glu Arg Ala Ala Ala Ser Thr Asp Tyr Tyr Lys Arg Gly Asp Phe
            260                 265                 270         
Ile Pro Gly Leu Arg Val Asp Gly Met Asp Ile Leu Cys Val Arg Glu
        275                 280                 285             
Ala Thr Arg Phe Ala Ala Ala Tyr Cys Arg Ser Gly Lys Gly Pro Ile
    290                 295                 300                 
Leu Met Glu Leu Gln Thr Tyr Arg Tyr His Gly His Ser Met Ser Asp
305                 310                 315                 320 
Pro Gly Val Ser Tyr Arg Thr Arg Glu Glu Ile Gln Glu Val Arg Ser
                325                 330                 335     
Lys Ser Asp Pro Ile Met Leu Leu Lys Asp Arg Met Val Asn Ser Asn
            340                 345                 350         
Leu Ala Ser Val Glu Glu Leu Lys Glu Ile Asp Val Glu Val Arg Lys
        355                 360                 365             
Glu Ile Glu Asp Pro Ala Gln Phe Ala Ala Ala Asp Pro Glu Pro Pro
    370                 375                 380                 
Leu Glu Glu Leu Gly Tyr His Ile Tyr Ser Ser Asp Pro Pro Phe Glu
385                 390                 395                 400 
Val Arg Gly Ala Asn Gln Trp Ile Lys Phe Lys Ser Val Ser
                405                 410                 


<210> 110
<211> 253
<212> PRT
<213> Homo sapiens

<400> 110
Met Ala Thr His Arg Leu Val Met Val Arg His Gly Glu Ser Thr Trp
 1               5                  10                  15      
Asn Gln Glu Asn Arg Phe Cys Gly Trp Phe Asp Ala Glu Leu Ser Glu
            20                  25                  30          
Lys Gly Thr Glu Glu Ala Lys Arg Gly Ala Lys Ala Ile Lys Asp Ala
        35                  40                  45              
Lys Met Glu Phe Asp Ile Cys Tyr Thr Ser Val Leu Lys Arg Ala Ile
    50                  55                  60                  
Pro Thr Leu Trp Ala Ile Leu Asp Gly Thr Asp Gln Met Trp Leu Pro
65                  70                  75                  80  
Val Val Arg Thr Cys Arg Phe Asn Glu Arg His Tyr Gly Gly Leu Thr
                85                  90                  95      
Gly Leu Asn Lys Ala Glu Thr Ala Ala Lys His Gly Glu Glu Gln Val
            100                 105                 110         
Lys Ile Trp Arg Arg Ser Phe Asp Ile Pro Pro Pro Pro Met Asp Glu
        115                 120                 125             
Lys His Pro Tyr Tyr Asn Ser Ile Ser Lys Glu Arg Arg Tyr Ala Gly
    130                 135                 140                 
Leu Lys Pro Gly Glu Leu Pro Thr Cys Glu Ser Leu Lys Asp Thr Ile
145                 150                 155                 160 
Ala Arg Ala Leu Pro Phe Trp Asn Glu Glu Ile Val Pro Gln Ile Lys
                165                 170                 175     
Ala Gly Lys Arg Val Leu Ile Ala Ala His Gly Asn Ser Leu Arg Gly
            180                 185                 190         
Ile Val Lys His Leu Glu Gly Met Ser Asp Gln Ala Ile Met Glu Leu
        195                 200                 205             
Asn Leu Pro Thr Gly Ile Pro Ile Val Tyr Glu Leu Asn Lys Glu Leu
    210                 215                 220                 
Lys Pro Thr Lys Pro Met Gln Phe Leu Gly Asp Glu Glu Thr Val Arg
225                 230                 235                 240 
Lys Ala Met Glu Ala Val Ala Ala Gln Gly Lys Ala Lys
                245                 250             


<210> 111
<211> 133
<212> PRT
<213> Homo sapiens

<400> 111
Thr Ile Thr Ala Val Gln Phe Ala Gly Arg Pro Phe Pro Arg Gly Lys
 1               5                  10                  15      
Glu Lys Ala Pro His Gln Gly Asp Tyr Pro Met Gly Gln Lys Asn Gln
            20                  25                  30          
Gln Ala Leu Ser Phe Cys Phe Phe His Trp Trp Ile Phe Pro His Ser
        35                  40                  45              
Arg Gly His Asn Cys Met Cys Trp Val Gln Tyr Leu Tyr Pro Lys Ser
    50                  55                  60                  
Glu Pro Ile Pro Gln Gln Ala Gly Gly Ser Val Ile Met Lys Gly Leu
65                  70                  75                  80  
Glu Lys Arg Ser Leu Phe Pro Ser Gly Thr Pro Leu Gln Thr Gln Leu
                85                  90                  95      
Arg Leu Pro Gln Gln Glu Cys Asn Met Glu Ala Pro Ile Asp Ser Ile
            100                 105                 110         
Ser Gly Thr Ile Gln Ser Glu Cys Ser Pro Thr Gly Gly Pro His Ser
        115                 120                 125             
Arg Phe Arg Pro Thr
    130             


<210> 112
<211> 193
<212> PRT
<213> Homo sapiens

<400> 112
Met Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg Pro Tyr Gly
 1               5                  10                  15      
Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile
            20                  25                  30          
Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu
        35                  40                  45              
Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His
    50                  55                  60                  
Thr Gly Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala
65                  70                  75                  80  
Leu Gly Arg Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu
                85                  90                  95      
Arg Ile His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu
            100                 105                 110         
Ala Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu
        115                 120                 125             
Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg
    130                 135                 140                 
Leu Ser Phe His Gln Gly Cys Thr Ile Val Ser Gln Arg Leu Thr Pro
145                 150                 155                 160 
Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu
                165                 170                 175     
Pro Ser Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg
            180                 185                 190         
Pro
    


<210> 113
<211> 528
<212> PRT
<213> Homo sapiens

<400> 113
Arg Arg Lys Met Ala Ala Val Val Leu Ala Ala Thr Arg Leu Leu Arg
 1               5                  10                  15      
Gly Ser Gly Ser Trp Gly Cys Ser Arg Leu Arg Phe Gly Pro Pro Ala
            20                  25                  30          
Tyr Arg Arg Phe Ser Ser Gly Gly Ala Tyr Pro Asn Ile Pro Leu Ser
        35                  40                  45              
Ser Pro Leu Pro Gly Val Pro Lys Pro Val Phe Ala Thr Val Asp Gly
    50                  55                  60                  
Gln Glu Lys Phe Glu Thr Lys Val Thr Thr Leu Asp Asn Gly Leu Arg
65                  70                  75                  80  
Val Ala Ser Gln Asn Lys Phe Gly Gln Phe Cys Thr Val Gly Ile Leu
                85                  90                  95      
Ile Asn Ser Gly Ser Arg Tyr Glu Ala Lys Tyr Leu Ser Gly Ile Ala
            100                 105                 110         
His Phe Leu Glu Lys Leu Ala Phe Ser Ser Thr Ala Arg Phe Asp Ser
        115                 120                 125             
Lys Asp Glu Ile Leu Leu Thr Leu Glu Lys His Gly Gly Ile Cys Asp
    130                 135                 140                 
Cys Gln Thr Ser Arg Asp Thr Thr Met Tyr Ala Val Ser Ala Asp Ser
145                 150                 155                 160 
Lys Gly Leu Asp Thr Val Val Ala Leu Leu Ala Asp Val Val Leu Gln
                165                 170                 175     
Pro Arg Leu Thr Asp Glu Glu Val Glu Met Thr Arg Met Ala Val Gln
            180                 185                 190         
Phe Glu Leu Glu Asp Leu Asn Leu Arg Pro Asp Pro Glu Pro Leu Leu
        195                 200                 205             
Thr Glu Met Ile His Glu Ala Ala Tyr Arg Glu Asn Thr Val Gly Leu
    210                 215                 220                 
His Arg Phe Cys Pro Thr Glu Asn Val Ala Lys Ile Asn Arg Glu Val
225                 230                 235                 240 
Leu His Ser Tyr Leu Arg Asn Tyr Tyr Thr Pro Asp Arg Met Val Leu
                245                 250                 255     
Ala Gly Val Gly Val Glu His Glu His Leu Val Asp Cys Ala Arg Lys
            260                 265                 270         
Tyr Leu Leu Gly Val Gln Pro Ala Trp Gly Ser Ala Glu Ala Val Asp
        275                 280                 285             
Ile Asp Arg Ser Val Ala Gln Tyr Thr Gly Gly Ile Ala Lys Leu Glu
    290                 295                 300                 
Arg Asp Met Ser Asn Val Ser Leu Gly Pro Thr Pro Ile Pro Glu Leu
305                 310                 315                 320 
Thr His Ile Met Val Gly Leu Glu Ser Cys Ser Phe Leu Glu Glu Asp
                325                 330                 335     
Phe Ile Pro Phe Ala Val Leu Asn Met Met Met Gly Gly Gly Gly Ser
            340                 345                 350         
Phe Ser Ala Gly Gly Pro Gly Lys Gly Met Phe Ser Arg Leu Tyr Leu
        355                 360                 365             
Asn Val Leu Asn Arg His His Trp Met Tyr Asn Ala Thr Ser Tyr His
    370                 375                 380                 
His Ser Tyr Glu Asp Thr Gly Leu Leu Cys Ile His Ala Ser Ala Asp
385                 390                 395                 400 
Pro Arg Gln Val Arg Glu Met Val Glu Ile Ile Thr Lys Glu Phe Ile
                405                 410                 415     
Leu Met Gly Gly Thr Val Asp Thr Val Glu Leu Glu Arg Ala Lys Thr
            420                 425                 430         
Gln Leu Thr Ser Met Leu Met Met Asn Leu Glu Ser Arg Pro Val Ile
        435                 440                 445             
Phe Glu Asp Val Gly Arg Gln Val Leu Ala Thr Arg Ser Arg Lys Leu
    450                 455                 460                 
Pro His Glu Leu Cys Thr Leu Ile Arg Asn Val Lys Pro Glu Asp Val
465                 470                 475                 480 
Lys Arg Val Ala Ser Lys Met Leu Arg Gly Lys Pro Ala Val Ala Ala
                485                 490                 495     
Leu Gly Asp Leu Thr Asp Leu Pro Thr Tyr Glu Asp Ile Gln Thr Ala
            500                 505                 510         
Leu Ser Ser Lys Asp Gly Arg Leu Pro Arg Thr Tyr Arg Leu Phe Arg
        515                 520                 525             


<210> 114
<211> 491
<212> PRT
<213> Homo sapiens

<400> 114
Arg Arg Phe Pro Pro Ala Gly Ala Val Ala Val Ile Glu Arg Gly Val
 1               5                  10                  15      
Arg Gly Gly Ser Gln Arg Cys Arg Thr Met Ala Asp Gln Leu Tyr Leu
            20                  25                  30          
Glu Asn Ile Asp Glu Phe Val Thr Asp Gln Asn Lys Ile Val Thr Tyr
        35                  40                  45              
Lys Trp Leu Ser Tyr Thr Leu Gly Val His Val Asn Gln Ala Lys Gln
    50                  55                  60                  
Met Leu Tyr Asp Tyr Val Glu Arg Lys Arg Lys Glu Asn Ser Gly Ala
65                  70                  75                  80  
Gln Leu His Val Thr Tyr Leu Val Ser Gly Ser Leu Ile Gln Asn Gly
                85                  90                  95      
His Ser Cys His Lys Val Ala Val Val Arg Glu Asp Lys Leu Glu Ala
            100                 105                 110         
Val Lys Ser Lys Leu Ala Val Thr Ala Ser Ile His Val Tyr Ser Ile
        115                 120                 125             
Gln Lys Ala Met Leu Lys Asp Ser Gly Pro Leu Phe Asn Thr Asp Tyr
    130                 135                 140                 
Asp Ile Leu Lys Ser Asn Leu Gln Asn Cys Ser Lys Phe Ser Ala Ile
145                 150                 155                 160 
Gln Cys Ala Ala Ala Val Pro Arg Ala Pro Ala Glu Ser Ser Ser Ser
                165                 170                 175     
Ser Lys Lys Phe Glu Gln Ser His Leu His Met Ser Ser Glu Thr Gln
            180                 185                 190         
Ala Asn Asn Glu Leu Thr Thr Asn Gly His Gly Pro Pro Ala Ser Lys
        195                 200                 205             
Gln Val Ser Gln Gln Pro Lys Gly Ile Met Gly Met Phe Ala Ser Lys
    210                 215                 220                 
Ala Ala Ala Lys Thr Gln Glu Thr Asn Lys Glu Thr Lys Thr Glu Ala
225                 230                 235                 240 
Lys Glu Val Thr Asn Ala Ser Ala Ala Gly Asn Lys Ala Pro Gly Lys
                245                 250                 255     
Gly Asn Met Met Ser Asn Phe Phe Gly Lys Ala Ala Met Asn Lys Phe
            260                 265                 270         
Lys Val Asn Leu Asp Ser Glu Gln Ala Val Lys Glu Glu Lys Ile Val
        275                 280                 285             
Glu Gln Pro Thr Val Ser Val Thr Glu Pro Lys Leu Ala Thr Pro Ala
    290                 295                 300                 
Gly Leu Lys Lys Ser Ser Lys Lys Ala Glu Pro Val Lys Val Leu Gln
305                 310                 315                 320 
Lys Glu Lys Lys Arg Gly Lys Arg Val Ala Leu Ser Asp Asp Glu Thr
                325                 330                 335     
Lys Glu Thr Glu Asn Met Arg Lys Lys Arg Arg Arg Ile Lys Leu Pro
            340                 345                 350         
Glu Ser Asp Ser Ser Glu Asp Glu Val Phe Pro Asp Ser Pro Gly Ala
        355                 360                 365             
Tyr Glu Ala Glu Ser Pro Ser Pro Pro Pro Pro Pro Ser Pro Pro Leu
    370                 375                 380                 
Glu Pro Val Pro Lys Thr Glu Pro Glu Pro Pro Ser Val Lys Ser Ser
385                 390                 395                 400 
Ser Gly Glu Asn Lys Arg Lys Arg Lys Arg Val Leu Lys Ser Lys Thr
                405                 410                 415     
Tyr Leu Asp Gly Glu Gly Cys Ile Val Thr Glu Lys Val Tyr Glu Ser
            420                 425                 430         
Glu Ser Cys Thr Asp Ser Glu Glu Glu Leu Asn Met Lys Thr Ser Ser
        435                 440                 445             
Val His Arg Pro Pro Ala Met Thr Val Lys Lys Glu Pro Arg Glu Glu
    450                 455                 460                 
Arg Lys Gly Pro Lys Lys Gly Thr Ala Ala Leu Gly Lys Ala Asn Arg
465                 470                 475                 480 
Gln Val Ser Ile Thr Gly Phe Phe Gln Arg Lys
                485                 490     


<210> 115
<211> 396
<212> PRT
<213> Homo sapiens

<400> 115
Met Asp Met His Cys Lys Ala Asp Pro Phe Ser Ala Met His Pro Gly
 1               5                  10                  15      
His Gly Gly Val Asn Gln Leu Gly Gly Val Phe Val Asn Gly Arg Pro
            20                  25                  30          
Leu Pro Asp Val Val Arg Gln Arg Ile Val Glu Leu Ala His Gln Gly
        35                  40                  45              
Val Arg Pro Cys Asp Ile Ser Arg Gln Leu Arg Val Ser His Gly Cys
    50                  55                  60                  
Val Ser Lys Ile Leu Gly Arg Tyr Tyr Glu Thr Gly Ser Ile Lys Pro
65                  70                  75                  80  
Gly Val Ile Gly Gly Ser Lys Pro Lys Val Ala Thr Pro Lys Val Val
                85                  90                  95      
Asp Lys Ile Ala Glu Tyr Lys Arg Gln Asn Pro Thr Met Phe Ala Trp
            100                 105                 110         
Glu Ile Arg Asp Arg Leu Leu Ala Glu Gly Ile Cys Asp Asn Asp Thr
        115                 120                 125             
Val Pro Ser Val Ser Ser Ile Asn Arg Ile Ile Arg Thr Lys Val Gln
    130                 135                 140                 
Gln Pro Phe His Pro Thr Pro Asp Gly Ala Gly Thr Gly Val Thr Ala
145                 150                 155                 160 
Pro Gly His Thr Ile Val Pro Ser Thr Ala Ser Pro Pro Val Ser Ser
                165                 170                 175     
Ala Ser Asn Asp Pro Val Gly Ser Tyr Ser Ile Asn Gly Ile Leu Gly
            180                 185                 190         
Ile Pro Arg Ser Asn Gly Glu Lys Arg Lys Arg Asp Glu Asp Val Ser
        195                 200                 205             
Glu Gly Ser Val Pro Asn Gly Asp Ser Gln Ser Gly Val Asp Ser Leu
    210                 215                 220                 
Arg Lys His Leu Arg Ala Asp Thr Phe Thr Gln Gln Gln Leu Glu Ala
225                 230                 235                 240 
Leu Asp Arg Val Phe Glu Arg Pro Ser Tyr Pro Asp Val Phe Gln Ala
                245                 250                 255     
Ser Glu His Ile Lys Ser Glu Gln Gly Asn Glu Tyr Ser Leu Pro Ala
            260                 265                 270         
Leu Thr Pro Gly Leu Asp Glu Val Lys Ser Ser Leu Ser Ala Ser Thr
        275                 280                 285             
Asn Pro Glu Leu Gly Ser Asn Val Ser Gly Thr Gln Thr Tyr Pro Val
    290                 295                 300                 
Val Thr Gly Arg Asp Met Ala Ser Thr Thr Leu Pro Gly Tyr Pro Pro
305                 310                 315                 320 
His Val Pro Pro Thr Gly Gln Gly Ser Tyr Pro Thr Ser Thr Leu Ala
                325                 330                 335     
Gly Met Val Pro Glu Ala Ala Val Gly Pro Ser Ser Ser Leu Met Ser
            340                 345                 350         
Lys Pro Gly Arg Lys Leu Ala Glu Val Pro Pro Cys Val Gln Pro Thr
        355                 360                 365             
Gly Ala Ser Ser Pro Ala Thr Arg Thr Ala Thr Pro Ser Thr Arg Pro
    370                 375                 380                 
Thr Thr Arg Leu Gly Asp Ser Ala Thr Pro Pro Tyr
385                 390                 395     


<210> 116
<211> 260
<212> PRT
<213> Homo sapiens

<400> 116
Gly Pro Arg Asp Gln Gly Ser Arg His Asp Ser Glu Gln Asp Asn Ser
 1               5                  10                  15      
Asp Asn Asn Thr Ile Phe Val Gln Gly Leu Gly Glu Asn Val Thr Ile
            20                  25                  30          
Glu Ser Val Ala Asp Tyr Phe Lys Gln Ile Gly Ile Ile Lys Thr Asn
        35                  40                  45              
Lys Lys Thr Gly Gln Pro Met Ile Asn Leu Tyr Thr Asp Arg Glu Thr
    50                  55                  60                  
Gly Lys Leu Lys Gly Glu Ala Thr Val Ser Phe Asp Asp Pro Pro Ser
65                  70                  75                  80  
Ala Lys Ala Ala Ile Asp Trp Phe Asp Gly Lys Glu Phe Ser Gly Asn
                85                  90                  95      
Pro Ile Lys Val Ser Phe Ala Thr Arg Arg Ala Asp Phe Asn Arg Gly
            100                 105                 110         
Gly Gly Asn Gly Arg Gly Gly Arg Gly Arg Gly Gly Pro Met Gly Glu
        115                 120                 125             
Gly Gly Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Arg Gly Gly Phe
    130                 135                 140                 
Pro Ser Gly Gly Gly Gly Gly Gly Gly Gln Gln Arg Ala Gly Asp Trp
145                 150                 155                 160 
Lys Cys Pro Asn Pro Thr Cys Glu Asn Met Asn Phe Ser Trp Arg Asn
                165                 170                 175     
Glu Cys Asn Gln Cys Lys Ala Pro Lys Phe Asp Gly Pro Gly Gly Gly
            180                 185                 190         
Pro Gly Gly Ser His Met Gly Gly Asn Tyr Gly Asp Asp Arg Arg Gly
        195                 200                 205             
Gly Arg Gly Gly Tyr Asp Arg Gly Gly Tyr Arg Gly Arg Gly Gly Asp
    210                 215                 220                 
Arg Gly Gly Phe Arg Gly Gly Arg Gly Gly Gly Asp Arg Gly Gly Phe
225                 230                 235                 240 
Gly Pro Gly Lys Met Asp Ser Arg Gly Glu His Arg Gln Asp Arg Arg
                245                 250                 255     
Glu Arg Pro Tyr
            260 


<210> 117
<211> 119
<212> PRT
<213> Homo sapiens

<400> 117
Lys Asn Phe Asp Asp Tyr Met Lys Ser Leu Gly Val Gly Phe Ala Thr
 1               5                  10                  15      
Arg Gln Val Ala Ser Met Thr Lys Pro Thr Thr Ile Ile Glu Lys Asn
            20                  25                  30          
Gly Asp Ile Leu Thr Leu Lys Thr His Ser Thr Phe Lys Asn Thr Glu
        35                  40                  45              
Ile Ser Phe Lys Leu Gly Val Glu Phe Asp Glu Thr Thr Ala Asp Asp
    50                  55                  60                  
Arg Lys Val Lys Ser Ile Val Thr Leu Asp Gly Gly Lys Leu Val His
65                  70                  75                  80  
Leu Gln Lys Trp Asp Gly Gln Glu Thr Thr Leu Val Arg Glu Leu Ile
                85                  90                  95      
Asp Gly Lys Leu Ile Leu Thr Leu Thr His Gly Thr Ala Val Cys Thr
            100                 105                 110         
Arg Thr Tyr Glu Lys Glu Ala
        115                 


<210> 118
<211> 1007
<212> PRT
<213> Homo sapiens

<400> 118
Met Lys Met Trp Leu Leu Val Ser His Leu Val Ile Ile Ser Ile Thr
 1               5                  10                  15      
Thr Cys Leu Ala Val Ser Glu Glu Asp Lys Gly Phe Gly Pro Ile Phe
            20                  25                  30          
Glu Glu Gln Pro Ile Asn Thr Ile Tyr Pro Glu Glu Ser Leu Glu Gly
        35                  40                  45              
Lys Val Ser Leu Asn Cys Arg Ala Arg Ala Ser Pro Phe Pro Val Tyr
    50                  55                  60                  
Lys Trp Arg Met Asn Asn Gly Asp Val Asp Leu Thr Ser Asp Arg Tyr
65                  70                  75                  80  
Ser Met Val Gly Gly Asn Leu Val Ile Asn Asn Pro Asp Lys Gln Lys
                85                  90                  95      
Asp Ala Gly Ile Tyr Tyr Cys Leu Ala Ser Asn Asn Tyr Gly Met Val
            100                 105                 110         
Arg Ser Thr Glu Ala Thr Leu Ser Phe Gly Tyr Leu Asp Pro Phe Pro
        115                 120                 125             
Pro Glu Glu Arg Pro Glu Val Arg Val Lys Glu Gly Lys Gly Met Val
    130                 135                 140                 
Leu Leu Cys Asp Pro Pro Tyr His Phe Pro Asp Asp Leu Ser Tyr Arg
145                 150                 155                 160 
Trp Leu Leu Asn Glu Phe Pro Val Phe Ile Thr Met Asp Lys Arg Arg
                165                 170                 175     
Phe Val Ser Gln Thr Asn Gly Asn Leu Tyr Ile Ala Asn Val Glu Ala
            180                 185                 190         
Ser Asp Lys Gly Asn Tyr Ser Cys Phe Val Ser Ser Pro Ser Ile Thr
        195                 200                 205             
Lys Ser Val Phe Ser Lys Phe Ile Pro Leu Ile Pro Ile Pro Glu Arg
    210                 215                 220                 
Thr Thr Lys Pro Tyr Pro Ala Asp Ile Val Val Gln Phe Lys Asp Val
225                 230                 235                 240 
Tyr Ala Leu Met Gly Gln Asn Val Thr Leu Glu Cys Phe Ala Leu Gly
                245                 250                 255     
Asn Pro Val Pro Asp Ile Arg Trp Arg Lys Val Leu Glu Pro Met Pro
            260                 265                 270         
Ser Thr Ala Glu Ile Ser Thr Ser Gly Ala Val Leu Lys Ile Phe Asn
        275                 280                 285             
Ile Gln Leu Glu Asp Glu Gly Ile Tyr Glu Cys Glu Ala Glu Asn Ile
    290                 295                 300                 
Arg Gly Lys Asp Lys His Gln Ala Arg Ile Tyr Val Gln Ala Phe Pro
305                 310                 315                 320 
Glu Trp Val Glu His Ile Asn Asp Thr Glu Val Asp Ile Gly Ser Asp
                325                 330                 335     
Leu Tyr Trp Pro Cys Val Ala Thr Gly Lys Pro Ile Pro Thr Ile Arg
            340                 345                 350         
Trp Leu Lys Asn Gly Tyr Ala Tyr His Lys Gly Glu Leu Arg Leu Tyr
        355                 360                 365             
Asp Val Thr Phe Glu Asn Ala Gly Met Tyr Gln Cys Ile Ala Glu Asn
    370                 375                 380                 
Thr Tyr Gly Ala Ile Tyr Ala Asn Ala Glu Leu Lys Ile Leu Ala Leu
385                 390                 395                 400 
Ala Pro Thr Phe Glu Met Asn Pro Met Lys Lys Lys Ile Leu Ala Ala
                405                 410                 415     
Lys Gly Gly Arg Val Ile Ile Glu Cys Lys Pro Lys Ala Ala Pro Lys
            420                 425                 430         
Pro Lys Phe Ser Trp Ser Lys Gly Thr Glu Trp Leu Val Asn Ser Ser
        435                 440                 445             
Arg Ile Leu Ile Trp Glu Asp Gly Ser Leu Glu Ile Asn Asn Ile Thr
    450                 455                 460                 
Arg Asn Asp Gly Gly Ile Tyr Thr Cys Phe Ala Glu Asn Asn Arg Gly
465                 470                 475                 480 
Lys Ala Asn Ser Thr Gly Thr Leu Val Ile Thr Asp Pro Thr Arg Ile
                485                 490                 495     
Ile Leu Ala Pro Ile Asn Ala Asp Ile Thr Val Gly Glu Asn Ala Thr
            500                 505                 510         
Met Gln Cys Ala Ala Ser Phe Asp Pro Ala Leu Asp Leu Thr Phe Val
        515                 520                 525             
Trp Ser Phe Asn Gly Tyr Val Ile Asp Phe Asn Lys Glu Asn Ile His
    530                 535                 540                 
Tyr Gln Arg Asn Phe Met Leu Asp Ser Asn Gly Glu Leu Leu Ile Arg
545                 550                 555                 560 
Asn Ala Gln Leu Lys His Ala Gly Arg Tyr Thr Cys Thr Ala Gln Thr
                565                 570                 575     
Ile Val Asp Asn Ser Ser Ala Ser Ala Asp Leu Val Val Arg Gly Pro
            580                 585                 590         
Pro Gly Pro Pro Gly Gly Leu Arg Ile Glu Asp Ile Arg Ala Thr Ser
        595                 600                 605             
Val Ala Leu Thr Trp Ser Arg Gly Ser Asp Asn His Ser Pro Ile Ser
    610                 615                 620                 
Lys Tyr Thr Ile Gln Thr Lys Thr Ile Leu Ser Asp Asp Trp Lys Asp
625                 630                 635                 640 
Ala Lys Thr Asp Pro Pro Ile Ile Glu Gly Asn Met Glu Ala Ala Arg
                645                 650                 655     
Ala Val Asp Leu Ile Pro Trp Met Glu Tyr Glu Phe Arg Val Val Ala
            660                 665                 670         
Thr Asn Thr Leu Gly Arg Gly Glu Pro Ser Ile Pro Ser Asn Arg Ile
        675                 680                 685             
Lys Thr Asp Gly Ala Ala Pro Asn Val Ala Pro Ser Asp Val Gly Gly
    690                 695                 700                 
Gly Gly Gly Arg Asn Arg Glu Leu Thr Ile Thr Trp Ala Pro Leu Ser
705                 710                 715                 720 
Arg Glu Tyr His Tyr Gly Asn Asn Phe Gly Tyr Ile Val Ala Phe Lys
                725                 730                 735     
Pro Phe Asp Gly Glu Glu Trp Lys Lys Val Thr Val Thr Asn Pro Asp
            740                 745                 750         
Thr Gly Arg Tyr Val His Lys Asp Glu Thr Met Ser Pro Ser Thr Ala
        755                 760                 765             
Phe Gln Val Lys Val Lys Ala Phe Asn Asn Lys Gly Asp Gly Pro Tyr
    770                 775                 780                 
Ser Leu Val Ala Val Ile Asn Ser Ala Gln Asp Ala Pro Ser Glu Ala
785                 790                 795                 800 
Pro Thr Glu Val Gly Val Lys Val Leu Ser Ser Ser Glu Ile Ser Val
                805                 810                 815     
His Trp Glu His Val Leu Glu Lys Ile Val Glu Ser Tyr Gln Ile Arg
            820                 825                 830         
Tyr Trp Ala Ala His Asp Lys Glu Glu Ala Ala Asn Arg Val Gln Val
        835                 840                 845             
Thr Ser Gln Glu Tyr Ser Ala Arg Leu Glu Asn Leu Leu Pro Asp Thr
    850                 855                 860                 
Gln Tyr Phe Ile Glu Val Gly Ala Cys Asn Ser Ala Gly Cys Gly Pro
865                 870                 875                 880 
Pro Ser Asp Met Ile Glu Ala Phe Thr Lys Lys Ala Pro Pro Ser Gln
                885                 890                 895     
Pro Pro Arg Ile Ile Ser Ser Val Arg Ser Gly Ser Arg Tyr Ile Ile
            900                 905                 910         
Thr Trp Asp His Val Val Ala Leu Ser Asn Glu Ser Thr Val Thr Gly
        915                 920                 925             
Tyr Lys Val Leu Tyr Arg Pro Asp Gly Gln His Asp Gly Lys Leu Tyr
    930                 935                 940                 
Ser Thr His Lys His Ser Ile Glu Val Pro Ile Pro Arg Asp Gly Glu
945                 950                 955                 960 
Tyr Val Val Glu Val Arg Ala His Ser Asp Gly Gly Asp Gly Val Val
                965                 970                 975     
Ser Gln Val Lys Ile Ser Gly Ala Pro Thr Leu Ser Pro Ser Leu Leu
            980                 985                 990         
Gly Leu Leu Leu Pro Ala Phe Gly Ile Leu Val Tyr Leu Glu Phe
        995                 1000                1005        


<210> 119
<211> 1333
<212> PRT
<213> Homo sapiens

<400> 119
Met Gln Ala Gln Gln Leu Pro Tyr Glu Phe Phe Ser Glu Glu Asn Ala
 1               5                  10                  15      
Pro Lys Trp Arg Gly Leu Leu Val Pro Ala Leu Lys Lys Val Gln Gly
            20                  25                  30          
Gln Val His Pro Thr Leu Glu Ser Asn Asp Asp Ala Leu Gln Tyr Val
        35                  40                  45              
Glu Glu Leu Ile Leu Gln Leu Leu Asn Met Leu Cys Gln Ala Gln Pro
    50                  55                  60                  
Arg Ser Ala Ser Asp Val Glu Glu Arg Val Gln Lys Ser Phe Pro His
65                  70                  75                  80  
Pro Ile Asp Lys Trp Ala Ile Ala Asp Ala Gln Ser Ala Ile Glu Lys
                85                  90                  95      
Arg Lys Arg Arg Asn Pro Leu Ser Leu Pro Val Glu Lys Ile His Pro
            100                 105                 110         
Leu Leu Lys Glu Val Leu Gly Tyr Lys Ile Asp His Gln Val Ser Val
        115                 120                 125             
Tyr Ile Val Ala Val Leu Glu Tyr Ile Ser Ala Asp Ile Leu Lys Leu
    130                 135                 140                 
Val Gly Asn Tyr Val Arg Asn Ile Arg His Tyr Glu Ile Thr Lys Gln
145                 150                 155                 160 
Asp Ile Lys Val Ala Met Cys Ala Asp Lys Val Leu Met Asp Met Phe
                165                 170                 175     
His Gln Asp Val Glu Asp Ile Asn Ile Leu Ser Leu Thr Asp Glu Glu
            180                 185                 190         
Pro Ser Thr Ser Gly Glu Gln Thr Tyr Tyr Asp Leu Val Lys Ala Phe
        195                 200                 205             
Met Ala Glu Ile Arg Gln Tyr Ile Arg Glu Leu Asn Leu Ile Ile Lys
    210                 215                 220                 
Val Phe Arg Glu Pro Phe Val Ser Asn Ser Lys Leu Phe Ser Ala Asn
225                 230                 235                 240 
Asp Val Glu Asn Ile Phe Ser Arg Ile Val Asp Ile His Glu Leu Ser
                245                 250                 255     
Val Lys Leu Leu Gly His Ile Glu Asp Thr Val Glu Met Thr Asp Glu
            260                 265                 270         
Gly Ser Pro His Pro Leu Val Gly Ser Cys Phe Glu Asp Leu Ala Glu
        275                 280                 285             
Glu Leu Ala Phe Asp Pro Tyr Glu Ser Tyr Ala Arg Asp Ile Leu Arg
    290                 295                 300                 
Pro Gly Phe His Asp Arg Phe Leu Ser Gln Leu Ser Lys Pro Gly Ala
305                 310                 315                 320 
Ala Leu Tyr Leu Gln Ser Ile Gly Glu Gly Phe Lys Glu Ala Val Gln
                325                 330                 335     
Tyr Val Leu Pro Arg Leu Leu Leu Ala Pro Val Tyr His Cys Leu His
            340                 345                 350         
Tyr Phe Glu Leu Leu Lys Gln Leu Glu Glu Lys Ser Glu Asp Gln Glu
        355                 360                 365             
Asp Lys Glu Cys Leu Lys Gln Ala Ile Thr Ala Leu Leu Asn Val Gln
    370                 375                 380                 
Ser Gly Met Glu Lys Ile Cys Ser Lys Ser Leu Ala Lys Arg Arg Leu
385                 390                 395                 400 
Ser Glu Ser Ala Cys Arg Phe Tyr Ser Gln Gln Met Lys Gly Lys Gln
                405                 410                 415     
Leu Ala Ile Lys Lys Met Asn Glu Ile Gln Lys Asn Ile Asp Gly Trp
            420                 425                 430         
Glu Gly Lys Asp Ile Gly Gln Cys Cys Asn Glu Phe Ile Met Glu Gly
        435                 440                 445             
Thr Leu Thr Arg Val Gly Ala Lys His Glu Arg His Ile Phe Leu Phe
    450                 455                 460                 
Asp Gly Leu Met Ile Cys Cys Lys Ser Asn His Gly Gln Pro Arg Leu
465                 470                 475                 480 
Pro Gly Ala Ser Asn Ala Glu Tyr Arg Leu Lys Glu Lys Phe Phe Met
                485                 490                 495     
Arg Lys Val Gln Ile Asn Asp Lys Asp Asp Thr Asn Glu Tyr Lys His
            500                 505                 510         
Ala Phe Glu Ile Ile Leu Lys Asp Glu Asn Ser Val Ile Phe Ser Ala
        515                 520                 525             
Lys Ser Ala Glu Glu Lys Asn Asn Trp Met Ala Ala Leu Ile Ser Leu
    530                 535                 540                 
Gln Tyr Arg Ser Thr Leu Glu Arg Met Leu Asp Val Thr Met Leu Gln
545                 550                 555                 560 
Glu Glu Lys Glu Glu Gln Met Arg Leu Pro Ser Ala Asp Val Tyr Arg
                565                 570                 575     
Phe Ala Glu Pro Asp Ser Glu Glu Asn Ile Ile Phe Glu Glu Asn Met
            580                 585                 590         
Gln Pro Lys Ala Gly Ile Pro Ile Ile Lys Ala Gly Thr Val Ile Lys
        595                 600                 605             
Leu Ile Glu Arg Leu Thr Tyr His Met Tyr Ala Asp Pro Asn Phe Val
    610                 615                 620                 
Arg Thr Phe Leu Thr Thr Tyr Arg Ser Phe Cys Lys Pro Gln Glu Leu
625                 630                 635                 640 
Leu Ser Leu Ile Ile Glu Arg Phe Glu Ile Pro Glu Pro Glu Pro Thr
                645                 650                 655     
Glu Ala Asp Arg Ile Ala Ile Glu Asn Gly Asp Gln Pro Leu Ser Ala
            660                 665                 670         
Glu Leu Lys Arg Phe Arg Lys Glu Tyr Ile Gln Pro Val Gln Leu Arg
        675                 680                 685             
Val Leu Asn Val Cys Arg His Trp Val Glu His His Phe Tyr Asp Phe
    690                 695                 700                 
Glu Arg Asp Ala Tyr Leu Leu Gln Arg Met Glu Glu Phe Ile Gly Thr
705                 710                 715                 720 
Val Arg Gly Lys Ala Met Lys Lys Trp Val Glu Ser Ile Thr Lys Ile
                725                 730                 735     
Ile Gln Arg Lys Lys Ile Ala Arg Asp Asn Gly Pro Gly His Asn Ile
            740                 745                 750         
Thr Phe Gln Ser Ser Pro Pro Thr Val Glu Trp His Ile Ser Arg Pro
        755                 760                 765             
Gly Phe Ile Glu Thr Phe Asp Leu Leu Thr Leu His Pro Ile Glu Ile
    770                 775                 780                 
Ala Arg Gln Leu Thr Leu Leu Glu Ser Asp Leu Tyr Arg Ala Val Gln
785                 790                 795                 800 
Pro Ser Glu Leu Val Gly Ser Val Trp Thr Lys Glu Asp Lys Glu Ile
                805                 810                 815     
Asn Ser Pro Asn Leu Leu Lys Met Ile Arg His Thr Thr Asn Leu Thr
            820                 825                 830         
Leu Trp Phe Glu Lys Cys Ile Val Glu Thr Glu Asn Leu Glu Glu Arg
        835                 840                 845             
Val Ala Val Val Ser Arg Ile Ile Glu Ile Leu Gln Val Phe Gln Glu
    850                 855                 860                 
Leu Asn Asn Phe Asn Gly Val Leu Glu Val Val Ser Ala Met Asn Ser
865                 870                 875                 880 
Ser Pro Val Tyr Arg Leu Asp His Thr Phe Glu Gln Ile Pro Ser Arg
                885                 890                 895     
Gln Lys Lys Ile Leu Glu Glu Ala His Glu Leu Ser Glu Asp His Tyr
            900                 905                 910         
Lys Lys Tyr Leu Ala Lys Leu Arg Ser Ile Asn Pro Pro Cys Val Pro
        915                 920                 925             
Phe Phe Gly Ile Tyr Leu Thr Asn Ile Leu Lys Thr Glu Glu Gly Asn
    930                 935                 940                 
Pro Glu Val Leu Lys Arg His Gly Lys Glu Leu Ile Asn Phe Ser Lys
945                 950                 955                 960 
Arg Arg Lys Val Ala Glu Ile Thr Gly Glu Ile Gln Gln Tyr Gln Asn
                965                 970                 975     
Gln Pro Tyr Cys Leu Arg Val Glu Ser Asp Ile Lys Arg Phe Phe Glu
            980                 985                 990         
Asn Leu Asn Pro Met Gly Asn Ser Met Glu Lys Glu Phe Thr Asp Tyr
        995                 1000                1005            
Leu Phe Asn Lys Ser Leu Glu Ile Glu Pro Arg Asn Pro Lys Pro Leu
    1010                1015                1020                
Pro Arg Phe Pro Lys Lys Tyr Ser Tyr Pro Leu Lys Ser Pro Gly Val
1025                1030                1035                1040
Arg Pro Ser Asn Pro Arg Pro Gly Thr Met Arg His Pro Thr Pro Leu
                1045                1050                1055    
Gln Gln Glu Pro Arg Lys Ile Ser Tyr Ser Arg Ile Pro Glu Ser Glu
            1060                1065                1070        
Thr Glu Ser Thr Ala Ser Ala Pro Asn Ser Pro Arg Thr Pro Leu Thr
        1075                1080                1085            
Pro Pro Pro Ala Ser Gly Ala Ser Ser Thr Thr Asp Val Cys Ser Val
    1090                1095                1100                
Phe Asp Ser Asp His Ser Ser Pro Phe His Ser Ser Asn Asp Thr Val
1105                1110                1115                1120
Phe Ile Gln Val Thr Leu Pro His Gly Pro Arg Ser Ala Ser Val Ser
                1125                1130                1135    
Ser Ile Ser Leu Thr Lys Gly Thr Asp Glu Val Pro Val Pro Pro Pro
            1140                1145                1150        
Val Pro Pro Arg Arg Arg Pro Glu Ser Ala Pro Ala Glu Ser Ser Pro
        1155                1160                1165            
Ser Lys Ile Met Ser Lys His Leu Asp Ser Pro Pro Ala Ile Pro Pro
    1170                1175                1180                
Arg Gln Pro Thr Ser Lys Ala Tyr Ser Pro Arg Tyr Ser Ile Ser Asp
1185                1190                1195                1200
Arg Thr Ser Ile Ser Asp Pro Pro Glu Ser Pro Pro Leu Leu Pro Pro
                1205                1210                1215    
Arg Glu Pro Val Arg Thr Pro Asp Val Phe Ser Ser Ser Pro Leu His
            1220                1225                1230        
Leu Gln Pro Pro Pro Leu Gly Lys Lys Ser Asp His Gly Asn Ala Phe
        1235                1240                1245            
Phe Pro Asn Ser Pro Ser Pro Phe Thr Pro Pro Pro Pro Gln Thr Pro
    1250                1255                1260                
Ser Pro His Gly Thr Arg Arg His Leu Pro Ser Pro Pro Leu Thr Gln
1265                1270                1275                1280
Glu Val Asp Leu His Ser Ile Ala Gly Pro Pro Val Pro Pro Arg Gln
                1285                1290                1295    
Ser Thr Ser Gln His Ile Pro Lys Leu Pro Pro Lys Thr Tyr Lys Arg
            1300                1305                1310        
Glu His Thr His Pro Ser Met His Arg Asp Gly Pro Pro Leu Leu Glu
        1315                1320                1325            
Asn Ala His Ser Ser
    1330            


<210> 120
<211> 1870
<212> PRT
<213> Homo sapiens

<400> 120
Met Ser Asp Arg Ser Gly Pro Thr Ala Lys Gly Lys Asp Gly Lys Lys
 1               5                  10                  15      
Tyr Ser Ser Leu Asn Leu Phe Asp Thr Tyr Lys Gly Lys Ser Leu Glu
            20                  25                  30          
Ile Gln Lys Pro Ala Cys Cys Pro Ser Pro Trp Pro Ala Glu Ser Arg
        35                  40                  45              
Glu Ser Cys His Cys Pro Ala Tyr Ala Pro Pro Ala Asn Leu Pro Ser
    50                  55                  60                  
Leu Lys Ala Glu Asn Lys Gly Asn Asp Pro Asn Val Ser Leu Val Pro
65                  70                  75                  80  
Lys Asp Gly Thr Gly Trp Ala Ser Lys Gln Glu Gln Ser Asp Pro Lys
                85                  90                  95      
Ser Ser Asp Ala Ser Thr Ala Gln Pro Pro Asn Arg Thr Thr Ala Gly
            100                 105                 110         
Phe Thr Asp Ala Cys Leu Gln Pro Ala Glu Arg Pro Pro Ala Ala Pro
        115                 120                 125             
Glu Asn Thr Pro Leu Val Pro Ser Gly Val Lys Ser Trp Ala Gln Ala
    130                 135                 140                 
Ser Val Thr His Gly Ala His Gly Asp Gly Gly Arg Ala Ser Ser Leu
145                 150                 155                 160 
Leu Ser Arg Phe Ser Arg Glu Glu Phe Pro Thr Leu Gln Ala Ala Gly
                165                 170                 175     
Asp Gln Asp Lys Ala Ala Lys Glu Arg Glu Ser Ala Glu Gln Ser Ser
            180                 185                 190         
Gly Pro Gly Pro Ser Leu Arg Pro Gln Asn Ser Thr Thr Trp Arg Asp
        195                 200                 205             
Gly Gly Gly Arg Gly Pro Asp Glu Leu Glu Gly Pro Asp Ser Lys Leu
    210                 215                 220                 
His His Gly His Asp Pro Arg Gly Gly Leu Gln Pro Ser Gly Pro Pro
225                 230                 235                 240 
Gln Phe Pro Pro Tyr Arg Gly Met Met Pro Pro Phe Met Tyr Pro Pro
                245                 250                 255     
Tyr Leu Pro Phe Pro Pro Pro Tyr Gly Pro Gln Gly Pro Tyr Arg Tyr
            260                 265                 270         
Pro Thr Pro Asp Gly Pro Ser Arg Phe Pro Arg Val Ala Gly Pro Arg
        275                 280                 285             
Gly Ser Gly Pro Pro Met Arg Leu Val Glu Pro Val Gly Arg Pro Ser
    290                 295                 300                 
Ile Leu Lys Glu Asp Asn Leu Lys Glu Phe Asp Gln Leu Asp Gln Glu
305                 310                 315                 320 
Asn Asp Asp Gly Trp Ala Gly Ala His Glu Glu Val Asp Tyr Thr Glu
                325                 330                 335     
Lys Leu Lys Phe Ser Asp Glu Glu Asp Gly Arg Asp Ser Asp Glu Glu
            340                 345                 350         
Gly Ala Glu Gly His Arg Asp Ser Gln Ser Ala Ser Gly Glu Glu Arg
        355                 360                 365             
Pro Pro Glu Ala Asp Gly Lys Lys Gly Asn Ser Pro Asn Ser Glu Pro
    370                 375                 380                 
Pro Thr Pro Lys Thr Ala Trp Ala Glu Thr Ser Arg Pro Pro Glu Thr
385                 390                 395                 400 
Glu Pro Gly Pro Pro Ala Pro Lys Pro Pro Leu Pro Pro Pro His Arg
                405                 410                 415     
Gly Pro Ala Gly Asn Trp Gly Pro Pro Gly Asp Tyr Pro Asp Arg Gly
            420                 425                 430         
Gly Pro Pro Cys Lys Pro Pro Ala Pro Glu Asp Glu Asp Glu Ala Trp
        435                 440                 445             
Arg Gln Arg Arg Lys Gln Ser Ser Ser Glu Ile Ser Leu Ala Val Glu
    450                 455                 460                 
Arg Ala Arg Arg Arg Arg Glu Glu Glu Glu Arg Arg Met Gln Glu Glu
465                 470                 475                 480 
Arg Arg Ala Ala Cys Ala Glu Lys Leu Lys Arg Leu Asp Glu Lys Phe
                485                 490                 495     
Gly Ala Pro Asp Lys Arg Leu Lys Ala Glu Pro Ala Ala Pro Pro Ala
            500                 505                 510         
Ala Pro Ser Thr Pro Ala Pro Pro Pro Ala Val Pro Lys Glu Leu Pro
        515                 520                 525             
Ala Pro Pro Ala Pro Pro Pro Ala Ser Ala Pro Thr Pro Glu Lys Glu
    530                 535                 540                 
Pro Glu Glu Pro Ala Gln Ala Pro Pro Ala Gln Ser Thr Pro Thr Pro
545                 550                 555                 560 
Gly Val Ala Ala Ala Pro Thr Leu Val Ser Gly Gly Gly Ser Thr Ser
                565                 570                 575     
Ser Thr Ser Ser Gly Ser Phe Glu Ala Ser Pro Val Glu Pro Gln Leu
            580                 585                 590         
Pro Ser Lys Glu Gly Pro Glu Pro Pro Glu Glu Val Pro Pro Pro Thr
        595                 600                 605             
Thr Pro Pro Val Pro Lys Val Glu Pro Lys Gly Asp Gly Ile Gly Pro
    610                 615                 620                 
Thr Arg Gln Pro Pro Ser Gln Gly Leu Gly Tyr Pro Lys Tyr Gln Lys
625                 630                 635                 640 
Ser Leu Pro Pro Arg Phe Gln Arg Gln Gln Gln Glu Gln Leu Leu Lys
                645                 650                 655     
Gln Gln Gln Gln His Gln Trp Gln Gln His Gln Gln Gly Ser Ala Pro
            660                 665                 670         
Pro Thr Pro Val Pro Pro Ser Pro Pro Gln Pro Val Thr Leu Gly Ala
        675                 680                 685             
Val Pro Ala Pro Lys Ala Pro Pro Pro Pro Pro Lys Ala Leu Tyr Pro
    690                 695                 700                 
Gly Ala Leu Gly Arg Pro Pro Pro Met Pro Pro Met Asn Phe Asp Pro
705                 710                 715                 720 
Arg Trp Met Met Ile Pro Pro Tyr Val Asp Pro Arg Leu Leu Gln Gly
                725                 730                 735     
Arg Pro Pro Leu Asp Phe Tyr Pro Pro Gly Val His Pro Ser Gly Leu
            740                 745                 750         
Val Pro Arg Glu Arg Ser Asp Ser Arg Gly Leu Ser Ser Glu Pro Phe
        755                 760                 765             
Asp Arg His Ala Pro Ala Met Leu Arg Glu Arg Gly Thr Pro Pro Val
    770                 775                 780                 
Asp Pro Lys Leu Ala Trp Val Gly Asp Val Phe Thr Ala Thr Pro Ala
785                 790                 795                 800 
Glu Pro Arg Pro Leu Thr Ser Pro Leu Arg Gln Ala Ala Asp Glu Asp
                805                 810                 815     
Asp Lys Gly Met Arg Ser Glu Thr Pro Pro Val Pro Pro Pro Pro Pro
            820                 825                 830         
Tyr Leu Ala Ser Tyr Pro Gly Phe Pro Glu Asn Gly Thr Pro Gly Pro
        835                 840                 845             
Pro Ile Ser Arg Phe Pro Leu Glu Glu Pro Gly Pro Arg Pro Leu Pro
    850                 855                 860                 
Trp Pro Pro Gly Ser Asp Glu Val Ala Lys Ile Gln Thr Pro Pro Pro
865                 870                 875                 880 
Lys Lys Glu Pro Pro Lys Glu Glu Thr Ala Gln Leu Thr Gly Pro Glu
                885                 890                 895     
Ala Gly Arg Lys Leu Pro Ala Ser Arg Ser Gly Ala Gly Pro Pro Pro
            900                 905                 910         
Pro Arg Arg Glu Ser Arg Thr Glu Thr Arg Trp Gly Pro Arg Pro Gly
        915                 920                 925             
Ser Ser Arg Arg Gly Ile Pro Pro Glu Glu Pro Gly Ala Pro Pro Arg
    930                 935                 940                 
Arg Ala Gly Pro Ile Lys Lys Pro Pro Pro Pro Thr Lys Val Glu Glu
945                 950                 955                 960 
Leu Pro Pro Lys Pro Leu Glu Gln Gly Asp Glu Thr Pro Lys Pro Pro
                965                 970                 975     
Lys Pro Asp Pro Leu Lys Ile Thr Lys Gly Lys Leu Gly Gly Pro Lys
            980                 985                 990         
Glu Thr Pro Pro Asn Gly Asn Leu Ser Pro Ala Pro Arg Leu Arg Arg
        995                 1000                1005            
Asp Tyr Ser Tyr Glu Arg Val Gly Pro Thr Ser Cys Arg Gly Arg Gly
    1010                1015                1020                
Arg Gly Glu Tyr Phe Ala Arg Gly Arg Gly Phe Arg Gly Thr Tyr Gly
1025                1030                1035                1040
Gly Arg Gly Arg Gly Ala Gln Ala Asn Ser Ala Val Thr Glu Ser Phe
                1045                1050                1055    
Glu Glu Met Met Gly Val Glu Val Gly Gln Gly Asp Gln Thr Thr Leu
            1060                1065                1070        
Leu Leu Pro Glu Ala Ala Leu Pro Ala Arg His Gly Ala Arg Val Gln
        1075                1080                1085            
Ser Met Arg Lys Ser Pro Ser Gly Ala Gly Ser Gly Ala Gln Lys Gln
    1090                1095                1100                
Ala Ala Arg Pro Met Arg Val Ile Trp Leu Leu Gln Thr Arg Arg Leu
1105                1110                1115                1120
Pro His Pro Arg Arg Glu His Ser Pro Arg Ser Ser Arg Ser Pro Thr
                1125                1130                1135    
Thr Arg Ser Pro Thr Leu His Arg Ala Pro Ala Arg Phe Thr Cys Pro
            1140                1145                1150        
Gly Val Gly Glu Ser Ser Leu Pro Glu Gly Ala Ile Ser Pro Gly Pro
        1155                1160                1165            
Arg Arg Arg Glu Ala Pro Pro Gln Val Cys Pro Gly Trp Ser Pro Pro
    1170                1175                1180                
Ala Lys Ser Leu Ala Pro Lys Lys Pro Pro Thr Gly Pro Leu Pro Pro
1185                1190                1195                1200
Ser Lys Glu Pro Leu Lys Glu Lys Leu Ile Pro Gly Pro Leu Ser Pro
                1205                1210                1215    
Val Ala Arg Gly Gly Ser Asn Gly Gly Ser Asn Val Gly Met Glu Asp
            1220                1225                1230        
Gly Glu Arg Pro Arg Arg Arg Arg His Gly Arg Ala Gln Gln Gln Asp
        1235                1240                1245            
Lys Pro Pro Arg Phe Arg Arg Leu Lys Gln Glu Arg Glu Asn Ala Ala
    1250                1255                1260                
Arg Gly Ser Glu Gly Lys Pro Ser Leu Thr Leu Pro Ala Ser Ala Pro
1265                1270                1275                1280
Gly Pro Glu Glu Ala Leu Thr Thr Val Thr Val Ala Pro Ala Pro Arg
                1285                1290                1295    
Arg Ala Ala Ala Lys Ser Pro Asp Leu Ser Asn Gln Asn Ser Asp Gln
            1300                1305                1310        
Ala Asn Glu Glu Trp Glu Thr Ala Ser Glu Ser Ser Asp Phe Thr Ser
        1315                1320                1325            
Glu Arg Arg Gly Asp Lys Glu Ala Pro Pro Pro Val Leu Leu Thr Pro
    1330                1335                1340                
Lys Ala Val Gly Thr Pro Gly Gly Gly Gly Gly Gly Ala Val Pro Gly
1345                1350                1355                1360
Ile Ser Ala Met Ser Arg Gly Asp Leu Ser Gln Arg Ala Lys Asp Leu
                1365                1370                1375    
Ser Lys Arg Ser Phe Ser Ser Gln Arg Pro Gly Met Glu Arg Gln Asn
            1380                1385                1390        
Arg Arg Pro Gly Pro Gly Gly Lys Ala Gly Ser Ser Gly Ser Ser Ser
        1395                1400                1405            
Gly Gly Ala Gly Gly Gly Pro Gly Gly Arg Thr Gly Pro Gly Arg Gly
    1410                1415                1420                
Asp Lys Arg Ser Trp Pro Ser Pro Lys Asn Arg Ser Arg Pro Pro Glu
1425                1430                1435                1440
Glu Arg Pro Pro Gly Leu Pro Leu Pro Pro Pro Pro Pro Ser Ser Ser
                1445                1450                1455    
Val Phe Arg Leu Asp Gln Val Ile His Ser Asn Pro Ala Gly Ile Gln
            1460                1465                1470        
Gln Ala Leu Ala Gln Leu Ser Ser Arg Gln Gly Ser Val Thr Ala Pro
        1475                1480                1485            
Gly Gly His Pro Arg His Lys Pro Gly Pro Pro Gln Ala Pro Gln Gly
    1490                1495                1500                
Pro Ser Pro Arg Pro Pro Thr Arg Tyr Glu Pro Gln Arg Val Asn Ser
1505                1510                1515                1520
Gly Leu Ser Ser Asp Pro His Phe Glu Glu Pro Gly Pro Met Val Arg
                1525                1530                1535    
Gly Val Gly Gly Thr Pro Arg Asp Ser Ala Gly Val Ser Pro Phe Pro
            1540                1545                1550        
Pro Lys Arg Arg Glu Arg Pro Pro Arg Lys Pro Glu Leu Leu Gln Glu
        1555                1560                1565            
Glu Ser Leu Pro Pro Pro His Ser Ser Gly Phe Leu Gly Ser Lys Pro
    1570                1575                1580                
Glu Gly Pro Gly Pro Gln Ala Glu Ser Arg Asp Thr Gly Thr Glu Ala
1585                1590                1595                1600
Leu Thr Pro His Ile Trp Asn Arg Leu His Thr Ala Thr Ser Arg Lys
                1605                1610                1615    
Ser Tyr Arg Pro Ser Ser Met Glu Pro Trp Met Glu Pro Leu Ser Pro
            1620                1625                1630        
Phe Glu Asp Val Ala Gly Thr Glu Met Ser Gln Ser Asp Ser Gly Val
        1635                1640                1645            
Asp Leu Ser Gly Asp Ser Gln Val Ser Ser Gly Pro Cys Ser Gln Arg
    1650                1655                1660                
Ser Ser Pro Asp Gly Gly Leu Lys Gly Ala Ala Glu Gly Pro Pro Lys
1665                1670                1675                1680
Arg Pro Gly Gly Ser Ser Pro Leu Asn Ala Val Pro Cys Glu Gly Pro
                1685                1690                1695    
Pro Gly Ser Glu Pro Pro Arg Arg Pro Pro Pro Ala Pro His Asp Gly
            1700                1705                1710        
Asp Arg Lys Glu Leu Pro Arg Glu Gln Pro Leu Pro Pro Gly Pro Ile
        1715                1720                1725            
Gly Thr Glu Arg Ser Gln Arg Thr Asp Arg Ala Thr Glu Pro Gly Pro
    1730                1735                1740                
Ile Arg Pro Ser His Arg Pro Gly Pro Pro Val Gln Phe Gly Thr Ser
1745                1750                1755                1760
Asp Lys Asp Ser Asp Leu Arg Leu Val Val Gly Asp Ser Leu Lys Ala
                1765                1770                1775    
Glu Lys Glu Leu Thr Ala Ser Val Thr Glu Ala Ile Pro Val Ser Arg
            1780                1785                1790        
Asp Trp Glu Leu Leu Pro Ser Ala Ala Ala Ser Ala Glu Pro Gln Ser
        1795                1800                1805            
Lys Asn Leu Asp Ser Gly His Cys Val Pro Glu Pro Ser Ser Ser Gly
    1810                1815                1820                
Gln Arg Leu Tyr Pro Glu Val Phe Tyr Gly Ser Ala Gly Pro Ser Ser
1825                1830                1835                1840
Ser Gln Ile Ser Gly Gly Ser His Gly Leu Ser Ile Thr Ser Lys Gln
                1845                1850                1855    
Trp Arg Leu Arg Pro Gly Thr Pro Ser Leu His Pro Tyr Arg
            1860                1865                1870


<210> 121
<211> 333
<212> PRT
<213> Homo sapiens

<400> 121
Met Glu Glu Asn Asp Pro Lys Pro Gly Glu Ala Ala Ala Ala Val Glu
 1               5                  10                  15      
Gly Gln Arg Gln Pro Glu Ser Ser Pro Gly Gly Gly Ser Gly Gly Gly
            20                  25                  30          
Gly Gly Ser Ser Pro Gly Glu Ala Asp Thr Gly Arg Arg Arg Ala Leu
        35                  40                  45              
Met Leu Pro Ala Val Leu Gln Ala Pro Gly Asn His Gln His Pro His
    50                  55                  60                  
Arg Ile Thr Asn Phe Phe Ile Asp Asn Ile Leu Arg Pro Glu Phe Gly
65                  70                  75                  80  
Arg Arg Lys Asp Ala Gly Thr Cys Cys Ala Gly Ala Gly Gly Gly Arg
                85                  90                  95      
Gly Gly Gly Ala Ala Ala Ala Gly Gly Gly Ser Gly Ala Glu Gly Gly
            100                 105                 110         
Gly Gly Ala Gly Gly Ser Glu Gln Leu Leu Gly Ser Gly Ser Arg Glu
        115                 120                 125             
Pro Arg Gln Asn Pro Pro Cys Ala Pro Gly Ala Gly Gly Pro Leu Pro
    130                 135                 140                 
Ala Ala Gly Ser Asp Ser Pro Gly Asp Gly Glu Gly Gly Ser Lys Thr
145                 150                 155                 160 
Leu Ser Leu His Gly Gly Ala Lys Lys Gly Gly Asp Pro Gly Gly Pro
                165                 170                 175     
Leu Asp Gly Ser Leu Lys Ala Arg Gly Leu Gly Gly Gly Asp Leu Ser
            180                 185                 190         
Val Ser Ser Asp Ser Asp Ser Ser Gln Ala Gly Ala Asn Leu Gly Ala
        195                 200                 205             
Gln Pro Met Leu Trp Pro Ala Trp Val Tyr Cys Thr Arg Tyr Ser Asp
    210                 215                 220                 
Arg Pro Ser Ser Gly Pro Arg Ser Arg Lys Pro Lys Lys Lys Asn Pro
225                 230                 235                 240 
Asn Lys Glu Asp Lys Arg Pro Arg Thr Ala Phe Thr Ala Glu Gln Leu
                245                 250                 255     
Gln Arg Leu Lys Ala Glu Phe Gln Thr Asn Arg Tyr Leu Thr Glu Gln
            260                 265                 270         
Arg Arg Gln Ser Leu Ala Gln Glu Leu Ser Leu Asn Glu Ser Gln Ile
        275                 280                 285             
Lys Ile Trp Phe Gln Asn Lys Arg Ala Lys Ile Lys Lys Ala Thr Gly
    290                 295                 300                 
Asn Lys Asn Thr Leu Ala Val His Leu Met Ala Gln Gly Leu Tyr Asn
305                 310                 315                 320 
His Ser Thr Thr Ala Lys Glu Gly Lys Ser Asp Ser Glu
                325                 330             


<210> 122
<211> 427
<212> PRT
<213> Homo sapiens

<400> 122
Met Ala Val Leu Ala Ala Leu Leu Arg Ser Gly Ala Arg Ser Arg Ser
 1               5                  10                  15      
Pro Leu Leu Arg Arg Leu Val Gln Glu Ile Arg Tyr Val Glu Arg Ser
            20                  25                  30          
Tyr Val Ser Lys Pro Thr Leu Lys Glu Val Val Ile Val Ser Ala Thr
        35                  40                  45              
Arg Thr Pro Ile Gly Ser Phe Leu Gly Ser Leu Ser Leu Leu Pro Ala
    50                  55                  60                  
Thr Lys Leu Gly Ser Ile Ala Ile Gln Gly Ala Ile Glu Lys Ala Gly
65                  70                  75                  80  
Ile Pro Lys Glu Glu Val Lys Glu Ala Tyr Met Gly Asn Val Leu Gln
                85                  90                  95      
Gly Gly Glu Gly Gln Ala Pro Thr Arg Gln Ala Val Leu Gly Ala Gly
            100                 105                 110         
Leu Pro Ile Ser Thr Pro Cys Thr Thr Ile Asn Lys Val Cys Ala Ser
        115                 120                 125             
Gly Met Lys Ala Ile Met Met Ala Ser Gln Ser Leu Met Cys Gly His
    130                 135                 140                 
Gln Asp Val Met Val Ala Gly Gly Met Glu Ser Met Ser Asn Val Pro
145                 150                 155                 160 
Tyr Val Met Asn Arg Gly Ser Thr Pro Tyr Gly Gly Val Lys Leu Glu
                165                 170                 175     
Asp Leu Ile Val Lys Asp Gly Leu Thr Asp Val Tyr Asn Lys Ile His
            180                 185                 190         
Met Gly Ser Cys Ala Glu Asn Thr Ala Lys Lys Leu Asn Ile Ala Arg
        195                 200                 205             
Asn Glu Gln Asp Ala Tyr Ala Ile Asn Ser Tyr Thr Arg Ser Lys Ala
    210                 215                 220                 
Ala Trp Glu Ala Gly Lys Phe Gly Asn Glu Val Ile Pro Val Thr Val
225                 230                 235                 240 
Thr Val Lys Gly Gln Pro Asp Val Val Val Lys Glu Asp Glu Glu Tyr
                245                 250                 255     
Lys Arg Val Asp Phe Ser Lys Val Pro Lys Leu Lys Thr Val Phe Gln
            260                 265                 270         
Lys Glu Asn Gly Thr Val Thr Ala Ala Asn Ala Ser Thr Leu Asn Asp
        275                 280                 285             
Gly Ala Ala Ala Leu Val Leu Met Thr Ala Asp Ala Ala Lys Arg Leu
    290                 295                 300                 
Asn Val Thr Pro Leu Ala Arg Ile Val Ala Phe Ala Asp Ala Ala Val
305                 310                 315                 320 
Glu Pro Ile Asp Phe Pro Ile Ala Pro Val Tyr Ala Ala Ser Met Val
                325                 330                 335     
Leu Lys Asp Met Gly Leu Lys Lys Glu Asn Ile Ala Met Trp Glu Val
            340                 345                 350         
Asn Glu Ala Phe Ser Leu Val Val Leu Ala Asn Ile Lys Met Leu Glu
        355                 360                 365             
Ile Asp Pro Gln Lys Val Asn Ile Asn Gly Gly Ser Val Ser Leu Gly
    370                 375                 380                 
His Pro Ile Gly Met Ser Gly Ala Arg Ile Val Gly His Leu Thr His
385                 390                 395                 400 
Ala Leu Lys Gln Gly Glu Tyr Gly Leu Ala Ser Phe Cys Asn Gly Gly
                405                 410                 415     
Gly Gly Ala Ser Ala Met Leu Ile Gln Lys Leu
            420                 425         


<210> 123
<211> 721
<212> PRT
<213> Homo sapiens

<400> 123
Thr Ser Gly Leu Thr Thr Gly Lys Ile Ala Gly Ala Gly Leu Leu Phe
 1               5                  10                  15      
Val Gly Gly Gly Ile Gly Gly Thr Ile Leu Tyr Ala Lys Trp Asp Ser
            20                  25                  30          
His Phe Arg Glu Ser Val Glu Lys Thr Ile Pro Tyr Ser Asp Lys Leu
        35                  40                  45              
Phe Glu Met Val Leu Gly Pro Ala Ala Tyr Asn Val Pro Leu Pro Lys
    50                  55                  60                  
Lys Ser Ile Gln Ser Gly Pro Leu Lys Ile Ser Ser Val Ser Glu Val
65                  70                  75                  80  
Met Lys Glu Ser Lys Gln Pro Ala Ser Gln Leu Gln Lys Gln Lys Gly
                85                  90                  95      
Asp Thr Pro Ala Ser Ala Thr Ala Pro Thr Glu Ala Ala Gln Ile Ile
            100                 105                 110         
Ser Ala Ala Gly Asp Thr Leu Ser Val Pro Ala Pro Ala Val Gln Pro
        115                 120                 125             
Glu Glu Ser Leu Lys Thr Asp His Pro Glu Ile Gly Glu Gly Lys Pro
    130                 135                 140                 
Thr Pro Ala Leu Ser Glu Glu Ala Ser Ser Ser Ser Ile Arg Glu Arg
145                 150                 155                 160 
Pro Pro Glu Glu Val Ala Ala Arg Leu Ala Gln Gln Glu Lys Gln Glu
                165                 170                 175     
Gln Val Lys Ile Glu Ser Leu Ala Lys Ser Leu Glu Asp Ala Leu Arg
            180                 185                 190         
Gln Thr Ala Ser Val Thr Leu Gln Ala Ile Ala Ala Gln Asn Ala Ala
        195                 200                 205             
Val Gln Ala Val Asn Ala His Ser Asn Ile Leu Lys Ala Ala Met Asp
    210                 215                 220                 
Asn Ser Glu Ile Ala Gly Glu Lys Lys Ser Ala Gln Trp Arg Thr Val
225                 230                 235                 240 
Glu Gly Ala Leu Lys Glu Arg Arg Lys Ala Val Asp Glu Ala Ala Asp
                245                 250                 255     
Ala Leu Leu Lys Ala Lys Glu Glu Leu Glu Lys Met Lys Ser Val Ile
            260                 265                 270         
Glu Asn Ala Lys Lys Lys Glu Val Ala Gly Ala Lys Pro His Ile Thr
        275                 280                 285             
Ala Ala Glu Gly Lys Leu His Asn Met Ile Val Asp Leu Asp Asn Val
    290                 295                 300                 
Val Lys Lys Val Gln Ala Ala Gln Ser Glu Ala Lys Val Val Ser Gln
305                 310                 315                 320 
Tyr His Glu Leu Val Val Gln Ala Arg Asp Asp Phe Lys Arg Glu Leu
                325                 330                 335     
Asp Ser Ile Thr Pro Glu Val Leu Pro Gly Trp Lys Gly Met Ser Val
            340                 345                 350         
Ser Asp Leu Ala Asp Lys Leu Ser Thr Asp Asp Leu Asn Ser Leu Ile
        355                 360                 365             
Ala His Ala His Arg Arg Ile Asp Gln Leu Asn Arg Glu Leu Ala Glu
    370                 375                 380                 
Gln Lys Ala Thr Glu Lys Gln His Ile Thr Leu Ala Leu Glu Lys Gln
385                 390                 395                 400 
Lys Leu Glu Glu Lys Arg Ala Phe Asp Ser Ala Val Ala Lys Ala Leu
                405                 410                 415     
Glu His His Arg Ser Glu Ile Gln Ala Glu Gln Asp Arg Lys Ile Glu
            420                 425                 430         
Glu Val Arg Asp Ala Met Glu Asn Glu Met Arg Thr Gln Leu Arg Arg
        435                 440                 445             
Gln Ala Ala Ala His Thr Asp His Leu Arg Asp Val Leu Arg Val Gln
    450                 455                 460                 
Glu Gln Glu Leu Lys Ser Glu Phe Glu Gln Asn Leu Ser Glu Lys Leu
465                 470                 475                 480 
Ser Glu Gln Glu Leu Gln Phe Arg Arg Leu Ser Gln Glu Gln Val Asp
                485                 490                 495     
Asn Phe Thr Leu Asp Ile Asn Thr Ala Tyr Ala Arg Leu Arg Gly Ile
            500                 505                 510         
Glu Gln Ala Val Gln Ser His Ala Val Ala Glu Glu Glu Ala Arg Lys
        515                 520                 525             
Ala His Gln Leu Trp Leu Ser Val Glu Ala Leu Lys Tyr Ser Met Lys
    530                 535                 540                 
Thr Ser Ser Ala Glu Thr Pro Thr Ile Pro Leu Gly Ser Ala Val Glu
545                 550                 555                 560 
Ala Ile Lys Ala Asn Cys Ser Asp Asn Glu Phe Thr Gln Ala Leu Thr
                565                 570                 575     
Ala Ala Ile Pro Pro Glu Ser Leu Thr Arg Gly Val Tyr Ser Glu Glu
            580                 585                 590         
Thr Leu Arg Ala Arg Phe Tyr Ala Val Gln Lys Leu Ala Arg Arg Val
        595                 600                 605             
Ala Met Ile Asp Glu Thr Arg Asn Ser Leu Tyr Gln Tyr Phe Leu Ser
    610                 615                 620                 
Tyr Leu Gln Ser Leu Leu Leu Phe Pro Pro Gln Gln Leu Lys Pro Pro
625                 630                 635                 640 
Pro Glu Leu Cys Pro Glu Asp Ile Asn Thr Phe Lys Leu Leu Ser Tyr
                645                 650                 655     
Ala Ser Tyr Cys Ile Glu His Gly Asp Leu Glu Leu Ala Ala Lys Phe
            660                 665                 670         
Val Asn Gln Leu Lys Gly Glu Ser Arg Arg Val Ala Gln Asp Trp Leu
        675                 680                 685             
Lys Glu Ala Arg Met Thr Leu Glu Thr Lys Gln Ile Val Glu Ile Leu
    690                 695                 700                 
Thr Ala Tyr Ala Ser Ala Val Gly Ile Gly Thr Thr Gln Val Gln Pro
705                 710                 715                 720 
Glu
    


<210> 124
<211> 758
<212> PRT
<213> Homo sapiens

<400> 124
Met Leu Arg Ala Cys Gln Leu Ser Gly Val Thr Ala Ala Ala Gln Ser
 1               5                  10                  15      
Cys Leu Cys Gly Lys Phe Val Leu Arg Pro Leu Arg Pro Cys Arg Arg
            20                  25                  30          
Tyr Ser Thr Ser Gly Ser Ser Gly Leu Thr Thr Gly Lys Ile Ala Gly
        35                  40                  45              
Ala Gly Leu Leu Phe Val Gly Gly Gly Ile Gly Gly Thr Ile Leu Tyr
    50                  55                  60                  
Ala Lys Trp Asp Ser His Phe Arg Glu Ser Val Glu Lys Thr Ile Pro
65                  70                  75                  80  
Tyr Ser Asp Lys Leu Phe Glu Met Val Leu Gly Pro Ala Ala Tyr Asn
                85                  90                  95      
Val Pro Leu Pro Lys Lys Ser Ile Gln Ser Gly Pro Leu Lys Ile Ser
            100                 105                 110         
Ser Val Ser Glu Val Met Lys Glu Ser Lys Gln Pro Ala Ser Gln Leu
        115                 120                 125             
Gln Lys Gln Lys Gly Asp Thr Pro Ala Ser Ala Thr Ala Pro Thr Glu
    130                 135                 140                 
Ala Ala Gln Ile Ile Ser Ala Ala Gly Asp Thr Leu Ser Val Pro Ala
145                 150                 155                 160 
Pro Ala Val Gln Pro Glu Glu Ser Leu Lys Thr Asp His Pro Glu Ile
                165                 170                 175     
Gly Glu Gly Lys Pro Thr Pro Ala Leu Ser Glu Glu Ala Ser Ser Ser
            180                 185                 190         
Ser Ile Arg Glu Arg Pro Pro Glu Glu Val Ala Ala Arg Leu Ala Gln
        195                 200                 205             
Gln Glu Lys Gln Glu Gln Val Lys Ile Glu Ser Leu Ala Lys Ser Leu
    210                 215                 220                 
Glu Asp Ala Leu Arg Gln Thr Ala Ser Val Thr Leu Gln Ala Ile Ala
225                 230                 235                 240 
Ala Gln Asn Ala Ala Val Gln Ala Val Asn Ala His Ser Asn Ile Leu
                245                 250                 255     
Lys Ala Ala Met Asp Asn Ser Glu Ile Ala Gly Glu Lys Lys Ser Ala
            260                 265                 270         
Gln Trp Arg Thr Val Glu Gly Ala Leu Lys Glu Arg Arg Lys Ala Val
        275                 280                 285             
Asp Glu Ala Ala Asp Ala Leu Leu Lys Ala Lys Glu Glu Leu Glu Lys
    290                 295                 300                 
Met Lys Ser Val Ile Glu Asn Ala Lys Lys Lys Glu Val Ala Gly Ala
305                 310                 315                 320 
Lys Pro His Ile Thr Ala Ala Glu Gly Lys Leu His Asn Met Ile Val
                325                 330                 335     
Asp Leu Asp Asn Val Val Lys Lys Val Gln Ala Ala Gln Ser Glu Ala
            340                 345                 350         
Lys Val Val Ser Gln Tyr His Glu Leu Val Val Gln Ala Arg Asp Asp
        355                 360                 365             
Phe Lys Arg Glu Leu Asp Ser Ile Thr Pro Glu Val Leu Pro Gly Trp
    370                 375                 380                 
Lys Gly Met Ser Val Ser Asp Leu Ala Asp Lys Leu Ser Thr Asp Asp
385                 390                 395                 400 
Leu Asn Ser Leu Ile Ala His Ala His Arg Arg Ile Asp Gln Leu Asn
                405                 410                 415     
Arg Glu Leu Ala Glu Gln Lys Ala Thr Glu Lys Gln His Ile Thr Leu
            420                 425                 430         
Ala Leu Glu Lys Gln Lys Leu Glu Glu Lys Arg Ala Phe Asp Ser Ala
        435                 440                 445             
Val Ala Lys Ala Leu Glu His His Arg Ser Glu Ile Gln Ala Glu Gln
    450                 455                 460                 
Asp Arg Lys Ile Glu Glu Val Arg Asp Ala Met Glu Asn Glu Met Arg
465                 470                 475                 480 
Thr Gln Leu Arg Arg Gln Ala Ala Ala His Thr Asp His Leu Arg Asp
                485                 490                 495     
Val Leu Arg Val Gln Glu Gln Glu Leu Lys Ser Glu Phe Glu Gln Asn
            500                 505                 510         
Leu Ser Glu Lys Leu Ser Glu Gln Glu Leu Gln Phe Arg Arg Leu Ser
        515                 520                 525             
Gln Glu Gln Val Asp Asn Phe Thr Leu Asp Ile Asn Thr Ala Tyr Ala
    530                 535                 540                 
Arg Leu Arg Gly Ile Glu Gln Ala Val Gln Ser His Ala Val Ala Glu
545                 550                 555                 560 
Glu Glu Ala Arg Lys Ala His Gln Leu Trp Leu Ser Val Glu Ala Leu
                565                 570                 575     
Lys Tyr Ser Met Lys Thr Ser Ser Ala Glu Thr Pro Thr Ile Pro Leu
            580                 585                 590         
Gly Ser Ala Val Glu Ala Ile Lys Ala Asn Cys Ser Asp Asn Glu Phe
        595                 600                 605             
Thr Gln Ala Leu Thr Ala Ala Ile Pro Pro Glu Ser Leu Thr Arg Gly
    610                 615                 620                 
Val Tyr Ser Glu Glu Thr Leu Arg Ala Arg Phe Tyr Ala Val Gln Lys
625                 630                 635                 640 
Leu Ala Arg Arg Val Ala Met Ile Asp Glu Thr Arg Asn Ser Leu Tyr
                645                 650                 655     
Gln Tyr Phe Leu Ser Tyr Leu Gln Ser Leu Leu Leu Phe Pro Pro Gln
            660                 665                 670         
Gln Leu Lys Pro Pro Pro Glu Leu Cys Pro Glu Asp Ile Asn Thr Phe
        675                 680                 685             
Lys Leu Leu Ser Tyr Ala Ser Tyr Cys Ile Glu His Gly Asp Leu Glu
    690                 695                 700                 
Leu Ala Ala Lys Phe Val Asn Gln Leu Lys Gly Glu Ser Arg Arg Val
705                 710                 715                 720 
Ala Gln Asp Trp Leu Lys Glu Ala Arg Met Thr Leu Glu Thr Lys Gln
                725                 730                 735     
Ile Val Glu Ile Leu Thr Ala Tyr Ala Ser Ala Val Gly Ile Gly Thr
            740                 745                 750         
Thr Gln Val Gln Pro Glu
        755             


<210> 125
<211> 770
<212> PRT
<213> Homo sapiens

<400> 125
Met Pro Ala Leu Gly Trp Ala Val Ala Ala Ile Leu Met Leu Gln Thr
 1               5                  10                  15      
Ala Met Ala Glu Pro Ser Pro Gly Thr Leu Pro Arg Lys Ala Gly Val
            20                  25                  30          
Phe Ser Asp Leu Ser Asn Gln Glu Leu Lys Ala Val His Ser Phe Leu
        35                  40                  45              
Trp Ser Lys Lys Glu Leu Arg Leu Gln Pro Ser Ser Thr Thr Thr Met
    50                  55                  60                  
Ala Lys Asn Thr Val Phe Leu Ile Glu Met Leu Leu Pro Lys Lys Tyr
65                  70                  75                  80  
His Val Leu Arg Phe Leu Asp Lys Gly Glu Arg His Pro Val Arg Glu
                85                  90                  95      
Ala Arg Ala Val Ile Phe Phe Gly Asp Gln Glu His Pro Asn Val Thr
            100                 105                 110         
Glu Phe Ala Val Gly Pro Leu Pro Gly Pro Cys Tyr Met Arg Ala Leu
        115                 120                 125             
Ser Pro Arg Pro Gly Tyr Gln Ser Ser Trp Ala Ser Arg Pro Ile Ser
    130                 135                 140                 
Thr Ala Glu Tyr Ala Leu Leu Tyr His Thr Leu Gln Glu Ala Thr Lys
145                 150                 155                 160 
Pro Leu His Gln Phe Phe Leu Asn Thr Thr Gly Phe Ser Phe Gln Asp
                165                 170                 175     
Cys His Asp Arg Cys Leu Ala Phe Thr Asp Val Ala Pro Arg Gly Val
            180                 185                 190         
Ala Ser Gly Gln Arg Arg Ser Trp Leu Ile Ile Gln Arg Tyr Val Glu
        195                 200                 205             
Gly Tyr Phe Leu His Pro Thr Gly Leu Glu Leu Leu Val Asp His Gly
    210                 215                 220                 
Ser Thr Asp Ala Gly His Trp Ala Val Glu Gln Val Trp Tyr Asn Gly
225                 230                 235                 240 
Lys Phe Tyr Gly Ser Pro Glu Glu Leu Ala Arg Lys Tyr Ala Asp Gly
                245                 250                 255     
Glu Val Asp Val Val Val Leu Glu Asp Pro Leu Pro Gly Gly Lys Gly
            260                 265                 270         
His Asp Ser Thr Glu Glu Pro Pro Leu Phe Ser Ser His Lys Pro Arg
        275                 280                 285             
Gly Asp Phe Pro Ser Pro Ile His Val Ser Gly Pro Arg Leu Val Gln
    290                 295                 300                 
Pro His Gly Pro Arg Phe Arg Leu Glu Gly Asn Ala Val Leu Tyr Gly
305                 310                 315                 320 
Gly Trp Ser Phe Ala Phe Arg Leu Arg Ser Ser Phe Gly Leu Gln Val
                325                 330                 335     
Leu Asn Val His Phe Gly Gly Glu Arg Ile Ala Tyr Glu Val Ser Val
            340                 345                 350         
Gln Glu Ala Val Ala Leu Tyr Gly Gly His Thr Pro Ala Gly Met Gln
        355                 360                 365             
Thr Lys Tyr Leu Asp Val Gly Trp Gly Leu Gly Ser Val Thr His Glu
    370                 375                 380                 
Leu Ala Pro Gly Ile Asp Cys Pro Glu Thr Ala Thr Phe Leu Asp Thr
385                 390                 395                 400 
Phe His Tyr Tyr Asp Ala Asp Asp Pro Val His Tyr Pro Arg Ala Leu
                405                 410                 415     
Cys Leu Phe Glu Met Pro Thr Gly Val Pro Leu Arg Arg His Phe Asn
            420                 425                 430         
Ser Asn Phe Lys Gly Gly Phe Asn Phe Tyr Ala Gly Leu Lys Gly Gln
        435                 440                 445             
Val Leu Val Leu Arg Thr Thr Ser Thr Val Tyr Asn Tyr Asp Tyr Ile
    450                 455                 460                 
Trp Asp Phe Ile Phe Tyr Pro Asn Gly Val Met Glu Ala Lys Met His
465                 470                 475                 480 
Ala Thr Gly Tyr Val His Ala Thr Phe Tyr Thr Pro Glu Gly Leu Arg
                485                 490                 495     
His Gly Thr Arg Leu His Thr His Leu Ile Gly Asn Ile His Thr His
            500                 505                 510         
Leu Val His Tyr Arg Val Asp Leu Asp Val Ala Gly Thr Lys Asn Ser
        515                 520                 525             
Phe Gln Thr Leu Gln Met Lys Leu Glu Asn Ile Thr Asn Pro Trp Ser
    530                 535                 540                 
Pro Arg His Arg Val Val Gln Pro Thr Leu Glu Gln Thr Gln Tyr Ser
545                 550                 555                 560 
Trp Glu Arg Gln Ala Ala Phe Arg Phe Lys Arg Lys Leu Pro Lys Tyr
                565                 570                 575     
Leu Leu Phe Thr Ser Pro Gln Glu Asn Pro Trp Gly His Lys Arg Ser
            580                 585                 590         
Tyr Arg Leu Gln Ile His Ser Met Ala Asp Gln Val Leu Pro Pro Gly
        595                 600                 605             
Trp Gln Glu Glu Gln Ala Ile Thr Trp Ala Arg Thr Glu Gly Gly Gln
    610                 615                 620                 
Pro Arg Ala Leu Ser Gln Ala Arg Ser Pro Val Pro Gly Arg Tyr Pro
625                 630                 635                 640 
Leu Ala Val Thr Lys Tyr Arg Glu Ser Glu Leu Cys Ser Ser Ser Ile
                645                 650                 655     
Tyr His Gln Asn Asp Pro Trp Asp Pro Pro Val Val Phe Glu Gln Phe
            660                 665                 670         
Leu His Asn Asn Glu Asn Ile Glu Asn Glu Asp Leu Val Ala Trp Val
        675                 680                 685             
Thr Val Gly Phe Leu His Ile Pro His Ser Glu Asp Ile Pro Asn Thr
    690                 695                 700                 
Ala Thr Pro Gly Asn Ser Val Gly Phe Leu Leu Arg Pro Phe Asn Phe
705                 710                 715                 720 
Phe Pro Glu Asp Pro Ser Leu Ala Ser Arg Asp Thr Val Ile Val Trp
                725                 730                 735     
Pro Arg Asp Asn Gly Pro Asn Tyr Val Gln Arg Trp Ile Pro Glu Asp
            740                 745                 750         
Arg Asp Cys Ser Met Pro Pro Pro Phe Ser Tyr Asn Gly Thr Tyr Arg
        755                 760                 765             
Pro Val
    770 


<210> 126
<211> 411
<212> PRT
<213> Homo sapiens

<400> 126
Met Gly Pro Leu Ser Ala Pro Pro Cys Thr Gln His Ile Thr Trp Lys
 1               5                  10                  15      
Gly Val Leu Leu Thr Ala Ser Leu Leu Asn Phe Trp Asn Leu Pro Ile
            20                  25                  30          
Thr Ala Gln Val Thr Ile Glu Ala Leu Pro Pro Lys Val Ser Glu Gly
        35                  40                  45              
Lys Asp Val Leu Leu Leu Val His Asn Leu Pro Gln Asn Leu Ala Gly
    50                  55                  60                  
Tyr Ile Trp Tyr Lys Gly Gln Leu Met Asp Leu Tyr His Tyr Ile Thr
65                  70                  75                  80  
Ser Tyr Val Val Asp Gly Gln Ile Asn Ile Tyr Gly Pro Ala Tyr Thr
                85                  90                  95      
Gly Arg Glu Thr Val Tyr Ser Asn Ala Ser Leu Leu Ile Gln Asn Val
            100                 105                 110         
Thr Arg Glu Asp Ala Gly Ser Tyr Thr Leu His Ile Ile Lys Arg Gly
        115                 120                 125             
Asp Arg Thr Arg Gly Val Thr Gly Tyr Phe Thr Phe Asn Leu Tyr Leu
    130                 135                 140                 
Glu Thr Pro Lys Pro Ser Ile Ser Ser Ser Asn Leu Asn Pro Arg Glu
145                 150                 155                 160 
Ala Met Glu Ala Val Ile Leu Thr Cys Asp Pro Ala Ala Ser Asp Thr
                165                 170                 175     
Ser Tyr Leu Trp Trp Met Asn Gly Gln Ser Leu Pro Met Thr His Arg
            180                 185                 190         
Leu Gln Leu Ser Lys Thr Asn Arg Thr Leu Phe Ile Phe Gly Val Thr
        195                 200                 205             
Lys Tyr Ile Ala Gly Pro Tyr Glu Cys Glu Ile Arg Asn Pro Val Ser
    210                 215                 220                 
Ala Ser His Ser Asp Pro Val Thr Leu Asn Leu Leu Leu Lys Leu Pro
225                 230                 235                 240 
Lys Pro Tyr Ile Thr Ile Asn Asn Ser Lys Pro Arg Glu Asn Lys Asp
                245                 250                 255     
Val Leu Ala Phe Thr Cys Glu Pro Lys Ser Glu Asn Tyr Thr Tyr Ile
            260                 265                 270         
Trp Trp Leu Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Val Lys Gln
        275                 280                 285             
Pro Ile Glu Asn Arg Ile Leu Ile Leu Pro Ser Val Thr Arg Asn Glu
    290                 295                 300                 
Thr Gly Pro Tyr Glu Cys Glu Ile Arg Asp Arg Asp Gly Gly Met His
305                 310                 315                 320 
Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Leu Pro Ser
                325                 330                 335     
Ile Tyr Pro Ser Phe Thr Tyr Tyr Arg Ser Gly Glu Asn Leu Tyr Leu
            340                 345                 350         
Ser Cys Phe Ala Glu Ser Asn Pro Pro Ala Glu Tyr Phe Trp Thr Ile
        355                 360                 365             
Asn Gly Lys Phe Gln Gln Ser Gly Gln Lys Leu Ser Ile Pro Gln Ile
    370                 375                 380                 
Thr Thr Lys His Arg Gly Leu Tyr Thr Cys Ser Val Arg Asn Ser Ala
385                 390                 395                 400 
Thr Gly Lys Glu Ser Ser Lys Ser Met Thr Val
                405                 410     


<210> 127
<211> 233
<212> PRT
<213> Homo sapiens

<400> 127
Leu Gly His Met Val Leu Phe Pro Val Trp Phe Leu Tyr Ser Leu Leu
 1               5                  10                  15      
Met Lys Leu Phe Gln Arg Ser Thr Pro Ala Ile Thr Leu Glu Ser Pro
            20                  25                  30          
Asp Ile Lys Tyr Pro Leu Arg Leu Ile Asp Arg Glu Ile Ile Ser His
        35                  40                  45              
Asp Thr Arg Arg Phe Arg Phe Ala Leu Pro Ser Pro Gln His Ile Leu
    50                  55                  60                  
Gly Leu Pro Val Gly Gln His Ile Tyr Leu Ser Ala Arg Ile Asp Gly
65                  70                  75                  80  
Asn Leu Val Val Arg Pro Tyr Thr Pro Ile Ser Ser Asp Asp Asp Lys
                85                  90                  95      
Gly Phe Val Asp Leu Val Ile Lys Val Tyr Phe Lys Asp Thr His Pro
            100                 105                 110         
Lys Phe Pro Ala Gly Gly Lys Met Ser Gln Tyr Leu Glu Ser Met Gln
        115                 120                 125             
Ile Gly Asp Thr Ile Glu Phe Arg Gly Pro Ser Gly Leu Leu Val Tyr
    130                 135                 140                 
Gln Gly Lys Gly Lys Phe Ala Ile Arg Pro Asp Lys Lys Ser Asn Pro
145                 150                 155                 160 
Ile Ile Arg Thr Val Lys Ser Val Gly Met Ile Ala Gly Gly Thr Gly
                165                 170                 175     
Ile Thr Pro Met Leu Gln Val Ile Gly Ala Ile Met Lys Asp Pro Asp
            180                 185                 190         
Asp His Thr Val Cys His Leu Leu Phe Ala Asn Gln Thr Glu Lys Asp
        195                 200                 205             
Ile Leu Leu Arg Pro Glu Leu Glu Glu Leu Arg Asn Lys His Ser Ala
    210                 215                 220                 
Arg Phe Lys Leu Trp Tyr Thr Leu Asp
225                 230             


<210> 128
<211> 176
<212> PRT
<213> Homo sapiens

<400> 128
Met Gly Asp Ser Glu Met Ala Val Phe Gly Ala Ala Ala Pro Tyr Leu
 1               5                  10                  15      
Arg Lys Ser Glu Lys Glu Arg Leu Glu Ala Gln Thr Arg Pro Phe Asp
            20                  25                  30          
Leu Lys Lys Asp Val Phe Val Pro Asp Asp Lys Gln Glu Phe Val Lys
        35                  40                  45              
Ala Lys Ile Val Ser Arg Glu Gly Gly Lys Val Thr Ala Glu Thr Glu
    50                  55                  60                  
Tyr Gly Lys Thr Val Thr Val Lys Glu Asp Gln Val Met Gln Gln Asn
65                  70                  75                  80  
Pro Pro Lys Phe Asp Lys Ile Gln Asp Met Ala Met Leu Thr Phe Leu
                85                  90                  95      
His Glu Pro Ala Val Leu Tyr Asn Leu Lys Glu Arg Tyr Gly Ser Trp
            100                 105                 110         
Met Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Thr Val Asn Pro Tyr
        115                 120                 125             
Lys Trp Leu Pro Val Tyr Thr Pro Glu Val Val Ala Ala Tyr Arg Gly
    130                 135                 140                 
Lys Lys Arg Ser Glu Ala Pro Pro His Ile Phe Ser Ile Ser Asp Asn
145                 150                 155                 160 
Ala Tyr Gln Tyr Met Leu Thr Asp Arg Glu Asn Gln Ser Ile Leu Ile
                165                 170                 175     


<210> 129
<211> 21
<212> PRT
<213> Homo sapiens

<400> 129
Cys Tyr Thr Gly Ala Asn Ser Lys Leu Thr Phe Gly Lys Gly Ile Thr
 1               5                  10                  15      
Leu Ser Val Arg Pro
            20      


<210> 130
<211> 21
<212> PRT
<213> Homo sapiens

<400> 130
Cys Tyr Thr Gly Ala Asn Ser Lys Leu Thr Phe Gly Lys Gly Ile Thr
 1               5                  10                  15      
Leu Ser Val Arg Pro
            20      


<210> 131
<211> 411
<212> PRT
<213> Homo sapiens

<400> 131
Glu Ala Gly Pro Ala Pro Leu Ser Ala Ala Ala Pro Gly Ala Gly Arg
 1               5                  10                  15      
Gly Trp Pro Arg Pro Leu Ala Glu Arg Arg Lys Gly Arg Gly Arg Arg
            20                  25                  30          
Gln Pro Leu Arg Ala Arg Leu Asn Arg Arg Arg Trp Ala Ala Gly Gln
        35                  40                  45              
Gly Ser Thr Val Gln Ala Ala Thr Phe Gly Pro Ala Met Ala Ala Ala
    50                  55                  60                  
Pro Leu Lys Val Cys Ile Val Gly Ser Gly Asn Trp Gly Ser Ala Val
65                  70                  75                  80  
Ala Lys Ile Ile Gly Asn Asn Val Lys Lys Leu Gln Lys Phe Ala Ser
                85                  90                  95      
Thr Val Lys Met Trp Val Phe Glu Glu Thr Val Asn Gly Arg Lys Leu
            100                 105                 110         
Thr Asp Ile Ile Asn Asn Asp His Glu Asn Val Lys Tyr Leu Pro Gly
        115                 120                 125             
His Lys Leu Pro Glu Asn Val Val Ala Met Ser Asn Leu Ser Glu Ala
    130                 135                 140                 
Val Gln Asp Ala Asp Leu Leu Val Phe Val Ile Pro His Gln Phe Ile
145                 150                 155                 160 
His Arg Ile Cys Asp Glu Ile Thr Gly Arg Val Pro Lys Lys Ala Leu
                165                 170                 175     
Gly Ile Thr Leu Ile Lys Gly Ile Asp Glu Gly Pro Glu Gly Leu Lys
            180                 185                 190         
Leu Ile Ser Asp Ile Ile Arg Glu Lys Met Gly Ile Asp Ile Ser Val
        195                 200                 205             
Leu Met Gly Ala Asn Ile Ala Asn Glu Val Ala Ala Glu Lys Phe Cys
    210                 215                 220                 
Glu Thr Thr Ile Gly Ser Lys Val Met Glu Asn Gly Leu Leu Phe Lys
225                 230                 235                 240 
Glu Leu Leu Gln Thr Pro Asn Phe Arg Ile Thr Val Val Asp Asp Ala
                245                 250                 255     
Asp Thr Val Glu Leu Cys Gly Ala Leu Lys Asn Ile Val Ala Val Gly
            260                 265                 270         
Ala Gly Phe Cys Asp Gly Leu Arg Cys Gly Asp Asn Thr Lys Ala Ala
        275                 280                 285             
Val Ile Arg Leu Gly Leu Met Glu Met Ile Ala Phe Ala Arg Ile Phe
    290                 295                 300                 
Cys Lys Gly Gln Val Ser Thr Ala Thr Phe Leu Glu Ser Cys Gly Val
305                 310                 315                 320 
Ala Asp Leu Ile Thr Thr Cys Tyr Gly Gly Arg Asn Arg Arg Val Ala
                325                 330                 335     
Glu Ala Phe Ala Arg Thr Gly Lys Thr Ile Glu Glu Leu Glu Lys Glu
            340                 345                 350         
Met Leu Asn Gly Gln Lys Leu Gln Gly Pro Gln Thr Ser Ala Glu Val
        355                 360                 365             
Tyr Arg Ile Leu Lys Gln Lys Gly Leu Leu Asp Lys Phe Pro Leu Phe
    370                 375                 380                 
Thr Ala Val Tyr Gln Ile Cys Tyr Glu Ser Arg Pro Val Gln Glu Met
385                 390                 395                 400 
Leu Ser Cys Leu Gln Ser His Pro Glu His Thr
                405                 410     


<210> 132
<211> 763
<212> PRT
<213> Homo sapiens

<400> 132
Met Val Ala Cys Arg Ala Ile Gly Ile Leu Ser Arg Phe Ser Ala Phe
 1               5                  10                  15      
Arg Ile Leu Arg Ser Arg Gly Tyr Ile Cys Arg Asn Phe Thr Gly Ser
            20                  25                  30          
Ser Ala Leu Leu Thr Arg Thr His Ile Asn Tyr Gly Val Lys Gly Asp
        35                  40                  45              
Val Ala Val Val Arg Ile Asn Ser Pro Asn Ser Lys Val Asn Thr Leu
    50                  55                  60                  
Ser Lys Glu Leu His Ser Glu Phe Ser Glu Val Met Asn Glu Ile Trp
65                  70                  75                  80  
Ala Ser Asp Gln Ile Arg Ser Ala Val Leu Ile Ser Ser Lys Pro Gly
                85                  90                  95      
Cys Phe Ile Ala Gly Ala Asp Ile Asn Met Leu Ala Ala Cys Lys Thr
            100                 105                 110         
Leu Gln Glu Val Thr Gln Leu Ser Gln Glu Ala Gln Arg Ile Val Glu
        115                 120                 125             
Lys Leu Glu Lys Ser Thr Lys Pro Ile Val Ala Ala Ile Asn Gly Ser
    130                 135                 140                 
Cys Leu Gly Gly Gly Leu Glu Leu Ala Ile Ser Cys Gln Tyr Arg Ile
145                 150                 155                 160 
Ala Thr Lys Asp Arg Lys Thr Val Leu Gly Ala Pro Glu Val Leu Leu
                165                 170                 175     
Gly Ile Leu Pro Gly Ala Gly Gly Thr Gln Arg Leu Pro Lys Met Val
            180                 185                 190         
Gly Val Pro Ala Val Phe Asp Met Met Leu Thr Gly Arg Asn Ile Arg
        195                 200                 205             
Ala Asp Ser Ala Lys Lys Met Gly Leu Val Asp Gln Leu Val Glu Pro
    210                 215                 220                 
Leu Gly Pro Gly Leu Lys Pro Pro Glu Glu Arg Thr Ile Glu Tyr Leu
225                 230                 235                 240 
Glu Glu Val Ala Ile Thr Phe Ala Lys Gly Leu Ala Asp Lys Lys Ile
                245                 250                 255     
Ser Pro Lys Arg Asp Lys Gly Leu Val Glu Lys Leu Thr Ala Tyr Ala
            260                 265                 270         
Met Thr Ile Pro Phe Val Arg Gln Gln Val Tyr Lys Lys Val Glu Glu
        275                 280                 285             
Lys Val Arg Lys Gln Thr Lys Gly Leu Tyr Pro Ala Pro Leu Lys Ile
    290                 295                 300                 
Ile Asp Val Val Lys Thr Gly Ile Glu Gln Gly Ser Asp Ala Gly Tyr
305                 310                 315                 320 
Leu Cys Glu Ser Gln Lys Phe Gly Glu Leu Val Met Thr Lys Glu Ser
                325                 330                 335     
Lys Ala Leu Met Gly Leu Tyr His Gly Gln Val Leu Cys Lys Lys Asn
            340                 345                 350         
Lys Phe Gly Ala Pro Gln Lys Asp Val Lys His Leu Ala Ile Leu Gly
        355                 360                 365             
Ala Gly Leu Met Gly Ala Gly Ile Ala Gln Val Ser Val Asp Lys Gly
    370                 375                 380                 
Leu Lys Thr Ile Leu Lys Asp Ala Thr Leu Thr Ala Leu Asp Arg Gly
385                 390                 395                 400 
Gln Gln Gln Val Phe Lys Gly Leu Asn Asp Lys Val Lys Lys Lys Ala
                405                 410                 415     
Leu Thr Ser Phe Glu Arg Asp Ser Ile Phe Ser Asn Leu Thr Gly Gln
            420                 425                 430         
Leu Asp Tyr Gln Gly Phe Glu Lys Ala Asp Met Val Ile Glu Ala Val
        435                 440                 445             
Phe Glu Asp Leu Ser Leu Lys His Arg Val Leu Lys Glu Val Glu Ala
    450                 455                 460                 
Val Ile Pro Asp His Cys Ile Phe Ala Ser Asn Thr Ser Ala Leu Pro
465                 470                 475                 480 
Ile Ser Glu Ile Ala Ala Val Ser Lys Arg Pro Glu Lys Val Ile Gly
                485                 490                 495     
Met His Tyr Phe Ser Pro Val Asp Lys Met Gln Leu Leu Glu Ile Ile
            500                 505                 510         
Thr Thr Glu Lys Thr Ser Lys Asp Thr Ser Ala Ser Ala Val Ala Val
        515                 520                 525             
Gly Leu Lys Gln Gly Lys Val Ile Ile Val Val Lys Asp Gly Pro Gly
    530                 535                 540                 
Phe Tyr Thr Thr Arg Cys Leu Ala Pro Met Met Ser Glu Val Ile Arg
545                 550                 555                 560 
Ile Leu Gln Glu Gly Val Asp Pro Lys Lys Leu Asp Ser Leu Thr Pro
                565                 570                 575     
Ser Phe Gly Phe Pro Val Gly Ala Ala Thr Leu Val Asp Glu Val Gly
            580                 585                 590         
Val Asp Val Ala Lys His Val Ala Glu Asp Leu Gly Lys Val Phe Gly
        595                 600                 605             
Glu Arg Phe Gly Gly Gly Asn Pro Glu Leu Leu Thr Gln Met Val Ser
    610                 615                 620                 
Lys Gly Phe Leu Gly Arg Lys Ser Gly Lys Gly Phe Tyr Ile Tyr Gln
625                 630                 635                 640 
Glu Gly Val Lys Arg Lys Asp Leu Asn Ser Asp Met Asp Ser Ile Leu
                645                 650                 655     
Ala Ser Leu Lys Leu Pro Pro Lys Ser Glu Val Ser Ser Asp Glu Asp
            660                 665                 670         
Ile Gln Phe Arg Leu Val Thr Arg Phe Val Asn Glu Ala Val Met Cys
        675                 680                 685             
Leu Gln Glu Gly Ile Leu Ala Thr Pro Ala Glu Gly Asp Ile Gly Ala
    690                 695                 700                 
Val Phe Gly Leu Gly Phe Pro Pro Cys Leu Gly Gly Pro Phe Arg Phe
705                 710                 715                 720 
Val Asp Leu Tyr Gly Ala Gln Lys Ile Val Asp Arg Leu Lys Lys Tyr
                725                 730                 735     
Glu Ala Ala Tyr Gly Lys Gln Phe Thr Pro Cys Gln Leu Leu Ala Asp
            740                 745                 750         
His Ala Asn Ser Pro Asn Lys Lys Phe Tyr Gln
        755                 760             


<210> 133
<211> 112
<212> PRT
<213> Homo sapiens

<400> 133
Met Asn Gly Ile Leu Ala Ser Leu Lys Met Pro Pro Lys Ser Glu Val
 1               5                  10                  15      
Ser Ser Asp Glu Asp Ile Gln Phe Arg Leu Leu Thr Arg Phe Val Asn
            20                  25                  30          
Glu Ala Val Thr Cys Pro Gln Glu Gly Ile Leu Ala Thr Pro Ala Glu
        35                  40                  45              
Gly Asp Ile Gly Ala Val Phe Gly Leu Ser Phe Pro Pro Cys Leu Gly
    50                  55                  60                  
Gly Pro Phe Cys Phe Val Asp Leu Tyr Glu Ala Gln Lys Ile Val Asp
65                  70                  75                  80  
Gly Leu Lys Lys Tyr Glu Ala Ala Tyr Gly Lys Glu Phe Thr Pro Ser
                85                  90                  95      
Gln Leu Leu Ala Asp His Thr Asn Ser Pro Asn Lys Lys Phe His Gln
            100                 105                 110         


<210> 134
<211> 1139
<212> PRT
<213> Homo sapiens

<400> 134
Met Pro Ser Gly Gly Asp Gln Ser Pro Pro Pro Pro Pro Pro Pro Pro
 1               5                  10                  15      
Ala Ala Ala Ala Ser Asp Glu Glu Glu Glu Asp Asp Gly Glu Ala Glu
            20                  25                  30          
Asp Ala Ala Pro Ser Ala Glu Ser Pro Thr Pro Gln Ile Gln Gln Arg
        35                  40                  45              
Phe Asp Glu Leu Cys Ser Arg Leu Asn Met Asp Glu Ala Ala Arg Pro
    50                  55                  60                  
Glu Ala Trp Asp Ser Tyr Arg Ser Met Ser Glu Ser Tyr Thr Leu Glu
65                  70                  75                  80  
Gly Asn Asp Leu His Trp Leu Ala Cys Ala Leu Tyr Val Ala Cys Arg
                85                  90                  95      
Lys Ser Val Pro Thr Val Ser Lys Gly Thr Val Glu Gly Asn Tyr Val
            100                 105                 110         
Ser Leu Thr Arg Ile Leu Lys Cys Ser Glu Gln Ser Leu Ile Glu Phe
        115                 120                 125             
Phe Asn Lys Met Lys Lys Trp Glu Asp Met Ala Asn Leu Pro Pro His
    130                 135                 140                 
Phe Arg Glu Arg Thr Glu Arg Leu Glu Arg Asn Phe Thr Val Ser Ala
145                 150                 155                 160 
Val Ile Phe Lys Lys Tyr Glu Pro Ile Phe Gln Asp Ile Phe Lys Tyr
                165                 170                 175     
Pro Gln Glu Glu Gln Pro Arg Gln Gln Arg Gly Arg Lys Gln Arg Arg
            180                 185                 190         
Gln Pro Cys Thr Val Ser Glu Ile Phe His Phe Cys Trp Val Leu Phe
        195                 200                 205             
Ile Tyr Ala Lys Gly Asn Phe Pro Met Ile Ser Asp Asp Leu Val Asn
    210                 215                 220                 
Ser Tyr His Leu Leu Leu Cys Ala Leu Asp Leu Val Tyr Gly Asn Ala
225                 230                 235                 240 
Leu Gln Cys Ser Asn Arg Lys Glu Leu Val Asn Pro Asn Phe Lys Gly
                245                 250                 255     
Leu Ser Glu Asp Phe His Ala Lys Asp Ser Lys Pro Ser Ser Asp Pro
            260                 265                 270         
Pro Cys Ile Ile Glu Lys Leu Cys Ser Leu His Asp Gly Leu Val Leu
        275                 280                 285             
Glu Ala Lys Gly Ile Lys Glu His Phe Trp Lys Pro Tyr Ile Arg Lys
    290                 295                 300                 
Leu Tyr Glu Lys Lys Leu Leu Lys Gly Lys Glu Glu Asn Leu Thr Gly
305                 310                 315                 320 
Phe Leu Glu Pro Gly Asn Phe Gly Glu Ser Phe Lys Ala Ile Asn Lys
                325                 330                 335     
Ala Tyr Glu Glu Tyr Val Leu Ser Val Gly Asn Leu Asp Glu Arg Ile
            340                 345                 350         
Phe Leu Gly Glu Asp Ala Glu Glu Glu Ile Gly Thr Leu Ser Arg Cys
        355                 360                 365             
Leu Asn Ala Gly Ser Gly Thr Glu Thr Ala Glu Arg Val Gln Met Lys
    370                 375                 380                 
Asn Ile Leu Gln Gln His Phe Asp Lys Ser Lys Ala Leu Arg Ile Ser
385                 390                 395                 400 
Thr Pro Leu Thr Gly Val Arg Tyr Ile Lys Glu Asn Ser Pro Cys Val
                405                 410                 415     
Thr Pro Val Ser Thr Ala Thr His Ser Leu Ser Arg Leu His Thr Met
            420                 425                 430         
Leu Thr Gly Leu Arg Asn Ala Pro Ser Glu Lys Leu Glu Gln Ile Leu
        435                 440                 445             
Arg Thr Cys Ser Arg Asp Pro Thr Gln Ala Ile Ala Asn Arg Leu Lys
    450                 455                 460                 
Glu Met Phe Glu Ile Tyr Ser Gln His Phe Gln Pro Asp Glu Asp Phe
465                 470                 475                 480 
Ser Asn Cys Ala Lys Glu Ile Ala Ser Lys His Phe Arg Phe Ala Glu
                485                 490                 495     
Met Leu Tyr Tyr Lys Val Leu Glu Ser Val Ile Glu Gln Glu Gln Lys
            500                 505                 510         
Arg Leu Gly Asp Met Asp Leu Ser Gly Ile Leu Glu Gln Asp Ala Phe
        515                 520                 525             
His Arg Ser Leu Leu Ala Cys Cys Leu Glu Val Val Thr Phe Ser Tyr
    530                 535                 540                 
Lys Pro Pro Gly Asn Phe Pro Phe Ile Thr Glu Ile Phe Asp Val Pro
545                 550                 555                 560 
Leu Tyr His Phe Tyr Lys Val Ile Glu Val Phe Ile Arg Ala Glu Asp
                565                 570                 575     
Gly Leu Cys Arg Glu Val Val Lys His Leu Asn Gln Ile Glu Glu Gln
            580                 585                 590         
Ile Leu Asp His Leu Ala Trp Lys Pro Glu Ser Pro Leu Trp Glu Lys
        595                 600                 605             
Ile Arg Asp Asn Glu Asn Arg Val Pro Thr Cys Glu Glu Val Met Pro
    610                 615                 620                 
Pro Gln Asn Leu Glu Arg Ala Asp Glu Ile Cys Ile Ala Gly Ser Pro
625                 630                 635                 640 
Leu Thr Pro Arg Arg Val Thr Glu Val Arg Ala Asp Thr Gly Gly Leu
                645                 650                 655     
Gly Arg Arg Leu Thr Ser Pro Thr Thr Leu Tyr Asp Arg Tyr Ser Ser
            660                 665                 670         
Pro Pro Ala Ser Thr Thr Arg Arg Arg Leu Phe Val Glu Asn Asp Ser
        675                 680                 685             
Pro Ser Asp Gly Gly Thr Pro Gly Arg Met Pro Pro Gln Pro Leu Val
    690                 695                 700                 
Asn Ala Val Pro Val Gln Asn Val Ser Gly Glu Thr Val Ser Val Thr
705                 710                 715                 720 
Pro Val Pro Gly Gln Thr Leu Val Thr Met Ala Thr Ala Thr Val Thr
                725                 730                 735     
Ala Asn Asn Gly Gln Thr Val Thr Ile Pro Val Gln Gly Ile Ala Asn
            740                 745                 750         
Glu Asn Gly Gly Ile Thr Phe Phe Pro Val Gln Val Asn Val Gly Gly
        755                 760                 765             
Gln Ala Gln Ala Val Thr Gly Ser Ile Gln Pro Leu Ser Ala Gln Ala
    770                 775                 780                 
Leu Ala Gly Ser Leu Ser Ser Gln Gln Val Thr Gly Thr Thr Leu Gln
785                 790                 795                 800 
Val Pro Gly Gln Val Ala Ile Gln Gln Ile Ser Pro Gly Gly Gln Gln
                805                 810                 815     
Gln Lys Gln Gly Gln Ser Val Thr Ser Ser Ser Asn Arg Pro Arg Lys
            820                 825                 830         
Thr Ser Ser Leu Ser Leu Phe Phe Arg Lys Val Tyr His Leu Ala Ala
        835                 840                 845             
Val Arg Leu Arg Asp Leu Cys Ala Lys Leu Asp Ile Ser Asp Glu Leu
    850                 855                 860                 
Arg Lys Lys Ile Trp Thr Cys Phe Glu Phe Ser Ile Ile Gln Cys Pro
865                 870                 875                 880 
Glu Leu Met Met Asp Arg His Leu Asp Gln Leu Leu Met Cys Ala Ile
                885                 890                 895     
Tyr Val Met Ala Lys Val Thr Lys Glu Asp Lys Ser Phe Gln Asn Ile
            900                 905                 910         
Met Arg Cys Tyr Arg Thr Gln Pro Gln Ala Arg Ser Gln Val Tyr Arg
        915                 920                 925             
Ser Val Leu Ile Lys Gly Lys Arg Lys Arg Arg Asn Ser Gly Ser Ser
    930                 935                 940                 
Asp Ser Arg Ser His Gln Asn Ser Pro Thr Glu Leu Asn Lys Asp Arg
945                 950                 955                 960 
Thr Ser Arg Asp Ser Ser Pro Val Met Arg Ser Ser Ser Thr Leu Pro
                965                 970                 975     
Val Pro Gln Pro Ser Ser Ala Pro Pro Thr Pro Thr Arg Leu Thr Gly
            980                 985                 990         
Ala Asn Ser Asp Met Glu Glu Glu Glu Arg Gly Asp Leu Ile Gln Phe
        995                 1000                1005            
Tyr Asn Asn Ile Tyr Ile Lys Gln Ile Lys Thr Phe Ala Met Lys Tyr
    1010                1015                1020                
Ser Gln Ala Asn Met Asp Ala Pro Pro Leu Ser Pro Tyr Pro Phe Val
1025                1030                1035                1040
Arg Thr Gly Ser Pro Arg Arg Ile Gln Leu Ser Gln Asn His Pro Val
                1045                1050                1055    
Tyr Ile Ser Pro His Lys Asn Glu Thr Met Leu Ser Pro Arg Glu Lys
            1060                1065                1070        
Ile Phe Tyr Tyr Phe Ser Asn Ser Pro Ser Lys Arg Leu Arg Glu Ile
        1075                1080                1085            
Asn Ser Met Ile Arg Thr Gly Glu Thr Pro Thr Lys Lys Arg Gly Ile
    1090                1095                1100                
Leu Leu Glu Asp Gly Ser Glu Ser Pro Ala Lys Arg Ile Cys Pro Glu
1105                1110                1115                1120
Asn His Ser Ala Leu Leu Arg Arg Leu Gln Asp Val Ala Asn Asp Arg
                1125                1130                1135    
Gly Ser His
            


<210> 135
<211> 2960
<212> PRT
<213> Homo sapiens

<400> 135
Met Pro Gly Ile Lys Val Gly Gly Ser Gly Val Asn Val Asn Ala Lys
 1               5                  10                  15      
Gly Leu Asp Leu Gly Gly Arg Gly Gly Val Gln Val Pro Ala Val Asp
            20                  25                  30          
Ile Ser Ser Ser Leu Gly Gly Arg Pro Val Glu Val Gln Gly Pro Ser
        35                  40                  45              
Leu Glu Ser Gly Asp His Ala Lys Ile Lys Phe Pro Thr Met Lys Val
    50                  55                  60                  
Pro Lys Phe Gly Val Ser Thr Gly Arg Glu Gly Gln Thr Pro Lys Ala
65                  70                  75                  80  
Gly Leu Arg Val Ser Ala Pro Glu Val Ser Val Gly His Lys Gly Gly
                85                  90                  95      
Lys Pro Gly Leu Thr Ile Gln Ala Pro Gln Leu Glu Val Ser Val Pro
            100                 105                 110         
Ser Ala Asn Ile Glu Gly Leu Glu Gly Lys Leu Lys Gly Pro Gln Ile
        115                 120                 125             
Thr Gly Pro Ser Leu Glu Gly Asp Leu Gly Leu Lys Gly Ala Lys Pro
    130                 135                 140                 
Gln Gly His Ile Gly Val Asp Ala Ser Ala Pro Gln Ile Gly Gly Ser
145                 150                 155                 160 
Ile Thr Gly Pro Ser Val Glu Val Gln Ala Pro Asp Ile Asp Val Gln
                165                 170                 175     
Gly Pro Gly Ser Lys Leu Asn Val Pro Lys Met Lys Val Pro Lys Phe
            180                 185                 190         
Ser Val Ser Gly Ala Lys Gly Glu Glu Thr Gly Ile Asp Val Thr Leu
        195                 200                 205             
Pro Thr Gly Glu Val Thr Val Pro Gly Val Ser Gly Asp Val Ser Leu
    210                 215                 220                 
Pro Glu Ile Ala Thr Gly Gly Leu Glu Gly Lys Met Lys Gly Thr Lys
225                 230                 235                 240 
Val Lys Thr Pro Glu Met Ile Ile Gln Lys Pro Lys Ile Ser Met Gln
                245                 250                 255     
Asp Val Asp Leu Ser Leu Gly Ser Pro Lys Leu Lys Gly Asp Ile Lys
            260                 265                 270         
Val Ser Ala Pro Gly Val Gln Gly Asp Val Lys Gly Pro Gln Val Ala
        275                 280                 285             
Leu Lys Gly Ser Arg Val Asp Ile Glu Thr Pro Asn Leu Glu Gly Thr
    290                 295                 300                 
Leu Thr Gly Pro Arg Leu Gly Ser Pro Ser Gly Lys Thr Gly Thr Cys
305                 310                 315                 320 
Arg Ile Ser Met Ser Glu Val Asp Leu Asn Val Ala Ala Pro Lys Val
                325                 330                 335     
Lys Gly Gly Val Asp Val Thr Leu Pro Arg Val Glu Gly Lys Val Lys
            340                 345                 350         
Val Pro Glu Val Asp Val Arg Gly Pro Lys Val Asp Val Ser Ala Pro
        355                 360                 365             
Asp Val Glu Ala His Gly Pro Glu Trp Asn Leu Lys Met Pro Lys Met
    370                 375                 380                 
Lys Met Pro Thr Phe Ser Thr Pro Gly Ala Lys Gly Glu Gly Pro Asp
385                 390                 395                 400 
Val His Met Thr Leu Pro Lys Gly Asp Ile Ser Ile Ser Gly Pro Lys
                405                 410                 415     
Val Asn Val Glu Ala Pro Asp Val Asn Leu Glu Gly Leu Gly Gly Lys
            420                 425                 430         
Leu Lys Gly Pro Asp Val Lys Leu Pro Asp Met Ser Val Lys Thr Pro
        435                 440                 445             
Lys Ile Ser Met Pro Asp Val Asp Leu His Val Lys Gly Thr Lys Val
    450                 455                 460                 
Lys Gly Glu Tyr Asp Val Thr Val Pro Lys Leu Glu Gly Glu Leu Lys
465                 470                 475                 480 
Gly Pro Lys Val Asp Ile Asp Ala Pro Asp Val Asp Val His Gly Pro
                485                 490                 495     
Asp Trp His Leu Lys Met Pro Lys Met Lys Met Pro Lys Phe Ser Val
            500                 505                 510         
Pro Gly Phe Lys Ala Glu Gly Pro Glu Val Asp Val Asn Leu Pro Lys
        515                 520                 525             
Ala Asp Val Asp Ile Ser Gly Pro Lys Ile Asp Val Thr Ala Pro Asp
    530                 535                 540                 
Val Ser Ile Glu Glu Pro Glu Gly Lys Leu Lys Gly Pro Lys Phe Lys
545                 550                 555                 560 
Met Pro Glu Met Asn Ile Lys Val Pro Lys Ile Ser Met Pro Asp Val
                565                 570                 575     
Asp Leu His Leu Lys Gly Pro Asn Val Lys Gly Glu Tyr Asp Val Thr
            580                 585                 590         
Met Pro Lys Val Glu Ser Glu Ile Lys Val Pro Asp Val Glu Leu Lys
        595                 600                 605             
Ser Ala Lys Met Asp Ile Asp Val Pro Asp Val Glu Val Gln Gly Pro
    610                 615                 620                 
Asp Trp His Leu Lys Met Pro Lys Met Lys Met Pro Lys Phe Ser Met
625                 630                 635                 640 
Pro Gly Phe Lys Ala Glu Gly Pro Glu Val Asp Val Asn Leu Pro Lys
                645                 650                 655     
Ala Asp Val Asp Ile Ser Gly Pro Lys Val Gly Val Glu Val Pro Asp
            660                 665                 670         
Val Asn Ile Glu Gly Pro Glu Gly Lys Leu Lys Gly Pro Lys Phe Lys
        675                 680                 685             
Met Pro Glu Met Asn Ile Lys Ala Pro Lys Ile Ser Met Pro Asp Val
    690                 695                 700                 
Asp Leu His Met Lys Gly Pro Lys Val Lys Gly Glu Tyr Asp Met Thr
705                 710                 715                 720 
Val Pro Lys Leu Glu Gly Asp Leu Lys Gly Pro Lys Val Asp Val Ser
                725                 730                 735     
Ala Pro Asp Val Glu Met Gln Gly Pro Asp Trp Asn Leu Lys Met Pro
            740                 745                 750         
Lys Ile Lys Met Pro Lys Phe Ser Met Pro Ser Leu Lys Gly Glu Gly
        755                 760                 765             
Pro Glu Phe Asp Val Asn Leu Ser Lys Ala Asn Val Asp Ile Ser Ala
    770                 775                 780                 
Pro Lys Val Asp Thr Asn Ala Pro Asp Leu Ser Leu Glu Gly Pro Glu
785                 790                 795                 800 
Gly Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met His Phe Arg
                805                 810                 815     
Ala Pro Lys Met Ser Leu Pro Asp Val Asp Leu Asp Leu Lys Gly Pro
            820                 825                 830         
Lys Met Lys Gly Asn Val Asp Ile Ser Ala Pro Lys Ile Glu Gly Glu
        835                 840                 845             
Met Gln Val Pro Asp Val Asp Ile Arg Gly Pro Lys Val Asp Ile Lys
    850                 855                 860                 
Ala Pro Asp Val Glu Gly Gln Gly Leu Asp Trp Ser Leu Lys Ile Pro
865                 870                 875                 880 
Lys Met Lys Met Pro Lys Phe Ser Met Pro Ser Leu Lys Gly Glu Gly
                885                 890                 895     
Pro Glu Val Asp Val Asn Leu Pro Lys Ala Asp Val Asp Val Ser Gly
            900                 905                 910         
Pro Lys Val Asp Ile Glu Ala Pro Asp Val Ser Leu Glu Gly Pro Glu
        915                 920                 925             
Gly Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met His Phe Lys
    930                 935                 940                 
Thr Pro Lys Ile Ser Met Pro Asp Val Asp Leu His Leu Lys Gly Pro
945                 950                 955                 960 
Lys Val Lys Gly Asp Val Asp Val Ser Val Pro Lys Val Glu Gly Glu
                965                 970                 975     
Met Lys Val Pro Asp Val Glu Ile Lys Gly Pro Lys Met Asp Ile Asp
            980                 985                 990         
Ala Pro Asp Val Glu Val Gln Gly Pro Asp Trp His Leu Lys Met Pro
        995                 1000                1005            
Lys Met Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Gly Glu Gly
    1010                1015                1020                
Arg Glu Val Asp Val Asn Leu Pro Lys Ala Asp Ile Asp Val Ser Gly
1025                1030                1035                1040
Pro Lys Val Asp Val Glu Val Pro Asp Val Ser Leu Glu Gly Pro Glu
                1045                1050                1055    
Gly Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met His Phe Lys
            1060                1065                1070        
Ala Pro Lys Ile Ser Met Pro Asp Val Asp Leu Asn Leu Lys Gly Pro
        1075                1080                1085            
Lys Leu Lys Gly Asp Val Asp Val Ser Leu Pro Glu Val Glu Gly Glu
    1090                1095                1100                
Met Lys Val Pro Asp Val Asp Ile Lys Gly Pro Lys Val Asp Ile Ser
1105                1110                1115                1120
Ala Pro Asp Val Asp Val His Gly Pro Asp Trp His Leu Lys Met Pro
                1125                1130                1135    
Lys Val Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Gly Glu Gly
            1140                1145                1150        
Pro Glu Val Asp Val Lys Leu Pro Lys Ala Asp Val Asp Val Ser Gly
        1155                1160                1165            
Pro Lys Met Asp Ala Glu Val Pro Asp Val Asn Ile Glu Gly Pro Asp
    1170                1175                1180                
Ala Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met Ser Ile Lys
1185                1190                1195                1200
Pro Gln Lys Ile Ser Ile Pro Asp Val Gly Leu His Leu Lys Gly Pro
                1205                1210                1215    
Lys Met Lys Gly Asp Tyr Asp Val Thr Val Pro Lys Val Glu Gly Glu
            1220                1225                1230        
Ile Lys Ala Pro Asp Val Asp Ile Lys Gly Pro Lys Val Asp Ile Asn
        1235                1240                1245            
Ala Pro Asp Val Glu Val His Gly Pro Asp Trp His Leu Lys Met Pro
    1250                1255                1260                
Lys Val Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Gly Glu Gly
1265                1270                1275                1280
Pro Glu Val Asp Met Asn Leu Pro Lys Ala Asp Leu Gly Val Ser Gly
                1285                1290                1295    
Pro Lys Val Asp Ile Asp Val Pro Asp Val Asn Leu Glu Ala Pro Glu
            1300                1305                1310        
Gly Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Ser Met Asn Ile Gln
        1315                1320                1325            
Thr His Lys Ile Ser Met Pro Asp Val Gly Leu Asn Leu Lys Ala Pro
    1330                1335                1340                
Lys Leu Lys Thr Asp Val Asp Val Ser Leu Pro Lys Val Glu Gly Asp
1345                1350                1355                1360
Leu Lys Gly Pro Glu Ile Asp Val Lys Ala Pro Lys Met Asp Val Asn
                1365                1370                1375    
Val Gly Asp Ile Asp Ile Glu Gly Pro Glu Gly Lys Leu Lys Gly Pro
            1380                1385                1390        
Lys Phe Lys Met Pro Glu Met His Phe Lys Ala Pro Lys Ile Ser Met
        1395                1400                1405            
Pro Asp Val Asp Leu His Leu Lys Gly Pro Lys Val Lys Gly Asp Met
    1410                1415                1420                
Asp Val Ser Val Pro Lys Val Glu Gly Glu Met Lys Val Pro Asp Val
1425                1430                1435                1440
Asp Ile Lys Gly Pro Lys Val Asp Ile Asp Ala Pro Asp Val Glu Val
                1445                1450                1455    
His Asp Pro Asp Trp His Leu Lys Met Pro Lys Met Lys Met Pro Lys
            1460                1465                1470        
Phe Ser Met Pro Gly Phe Lys Ala Glu Gly Pro Glu Val Asp Val Asn
        1475                1480                1485            
Leu Arg Lys Ala Asp Ile Asp Val Ser Gly Pro Ser Val Asp Thr Asp
    1490                1495                1500                
Ala Pro Asp Leu Asp Ile Glu Gly Pro Glu Gly Lys Leu Lys Gly Ser
1505                1510                1515                1520
Lys Phe Lys Met Pro Lys Leu Asn Ile Lys Ala Pro Lys Val Ser Met
                1525                1530                1535    
Pro Asp Val Asp Leu Asn Leu Lys Gly Pro Lys Leu Lys Gly Glu Ile
            1540                1545                1550        
Asp Ala Ser Val Pro Glu Leu Glu Gly Asp Leu Arg Gly Pro Gln Val
        1555                1560                1565            
Asp Val Lys Gly Pro Leu Val Glu Ala Glu Val Pro Asp Val Asp Leu
    1570                1575                1580                
Glu Cys Pro Asp Ala Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu
1585                1590                1595                1600
Met His Phe Lys Ala Pro Lys Ile Ser Met Pro Asp Val Asp Leu His
                1605                1610                1615    
Leu Lys Gly Pro Lys Val Lys Gly Asp Ala Asp Val Ser Val Pro Lys
            1620                1625                1630        
Leu Glu Gly Asp Leu Thr Gly Pro Ser Val Gly Val Glu Val Pro Asp
        1635                1640                1645            
Val Glu Leu Glu Cys Pro Asp Ala Lys Leu Lys Gly Pro Lys Phe Lys
    1650                1655                1660                
Met Pro Asp Met His Phe Lys Ala Pro Lys Ile Ser Met Pro Asp Val
1665                1670                1675                1680
Asp Leu His Thr Leu Pro Lys Val Glu Gly Asp Leu Lys Gly Pro Glu
                1685                1690                1695    
Ala Asp Ile Lys Gly Pro Lys Val Asp Ile Asn Thr Pro Asp Val Asp
            1700                1705                1710        
Val His Gly Pro Asp Trp His Leu Lys Met Pro Lys Val Lys Met Pro
        1715                1720                1725            
Lys Phe Ser Met Pro Gly Phe Lys Gly Glu Gly Pro Asp Val Asp Val
    1730                1735                1740                
Asn Leu Pro Lys Ala Asp Ile Asp Val Ser Gly Pro Lys Val Asp Val
1745                1750                1755                1760
Asp Val Pro Asp Val Asn Ile Glu Gly Pro Asp Ala Lys Leu Lys Gly
                1765                1770                1775    
Pro Lys Phe Lys Met Pro Glu Met Ser Ile Lys Ala Pro Lys Ile Ser
            1780                1785                1790        
Met Pro Asp Ile Asp Leu Asn Leu Lys Gly Pro Lys Val Lys Gly Asp
        1795                1800                1805            
Val Asp Val Thr Leu Pro Lys Val Glu Gly Asp Leu Lys Gly Pro Glu
    1810                1815                1820                
Ala Asp Ile Lys Gly Pro Lys Val Asp Ile Asn Thr Pro Asp Val Asp
1825                1830                1835                1840
Val His Gly Pro Asp Trp His Leu Lys Met Pro Lys Val Lys Met Pro
                1845                1850                1855    
Lys Phe Ser Met Pro Gly Phe Lys Gly Glu Gly Pro Asp Val Asp Val
            1860                1865                1870        
Ser Leu Pro Lys Ala Asp Ile Asp Val Ser Gly Pro Lys Val Asp Val
        1875                1880                1885            
Asp Ile Pro Asp Val Asn Ile Glu Gly Pro Asp Pro Lys Leu Lys Val
    1890                1895                1900                
Pro Lys Val Lys Met Pro Glu Ile Asn Ile Lys Ala Pro Lys Ile Ser
1905                1910                1915                1920
Ile Pro Asp Val Asp Leu Asp Leu Lys Gly Pro Lys Val Lys Gly Asp
                1925                1930                1935    
Phe Asp Val Ser Val Pro Lys Val Glu Gly Thr Leu Lys Gly Pro Glu
            1940                1945                1950        
Val Asp Leu Lys Gly Pro Arg Leu Asp Phe Glu Gly Pro Asp Ala Lys
        1955                1960                1965            
Leu Ser Gly Pro Ser Leu Lys Met Pro Ser Leu Glu Ile Ser Ala Pro
    1970                1975                1980                
Lys Val Thr Ala Pro Asp Val Asp Leu His Leu Lys Ala Pro Lys Ile
1985                1990                1995                2000
Gly Phe Ser Gly Pro Lys Leu Glu Gly Gly Glu Val Asp Leu Lys Gly
                2005                2010                2015    
Pro Lys Val Glu Ala Pro Ser Leu Asp Val His Met Asp Ser Pro Asp
            2020                2025                2030        
Ile Asn Ile Glu Gly Pro Asp Val Lys Ile Pro Lys Phe Lys Lys Pro
        2035                2040                2045            
Lys Phe Gly Phe Gly Pro Lys Ser Pro Lys Ala Asp Ile Lys Ser Pro
    2050                2055                2060                
Ser Leu Asp Val Thr Val Pro Glu Ala Glu Leu Asn Leu Glu Thr Pro
2065                2070                2075                2080
Glu Ile Ser Val Gly Gly Lys Gly Lys Lys Ser Lys Phe Lys Met Pro
                2085                2090                2095    
Lys Ile His Met Ser Gly Pro Lys Ile Lys Ala Lys Lys Gln Gly Phe
            2100                2105                2110        
Asp Leu Asn Val Pro Gly Gly Glu Ile Asp Ala Ser Leu Lys Ala Pro
        2115                2120                2125            
Asp Val Asp Val Asn Ile Ala Gly Pro Asp Ala Ala Leu Lys Val Asp
    2130                2135                2140                
Val Lys Ser Pro Lys Thr Lys Lys Thr Met Phe Gly Lys Met Tyr Phe
2145                2150                2155                2160
Pro Asp Val Glu Phe Asp Ile Lys Ser Pro Lys Phe Lys Ala Glu Ala
                2165                2170                2175    
Pro Leu Pro Ser Pro Lys Leu Glu Gly Glu Leu Gln Ala Pro Asp Leu
            2180                2185                2190        
Glu Leu Ser Leu Pro Ala Ile His Val Glu Gly Leu Asp Ile Lys Ala
        2195                2200                2205            
Lys Ala Pro Lys Val Lys Met Pro Asp Val Asp Ile Ser Val Pro Lys
    2210                2215                2220                
Ile Glu Gly Asp Leu Lys Gly Pro Lys Val Gln Ala Asn Leu Gly Ala
2225                2230                2235                2240
Pro Asp Ile Asn Ile Glu Gly Leu Asp Ala Lys Val Lys Thr Pro Ser
                2245                2250                2255    
Phe Gly Ile Ser Ala Pro Gln Val Ser Ile Pro Asp Val Asn Val Asn
            2260                2265                2270        
Leu Lys Gly Pro Lys Ile Lys Gly Asp Val Pro Ser Val Gly Leu Glu
        2275                2280                2285            
Gly Pro Asp Val Asp Leu Gln Gly Pro Glu Ala Lys Ile Lys Phe Pro
    2290                2295                2300                
Lys Phe Ser Met Pro Lys Ile Gly Ile Pro Gly Val Lys Met Glu Gly
2305                2310                2315                2320
Gly Gly Ala Glu Val His Ala Gln Leu Pro Ser Leu Glu Gly Asp Leu
                2325                2330                2335    
Arg Gly Pro Asp Val Lys Leu Glu Gly Pro Asp Val Ser Leu Lys Gly
            2340                2345                2350        
Pro Gly Val Asp Leu Pro Ser Val Asn Leu Ser Met Pro Lys Val Ser
        2355                2360                2365            
Gly Pro Asp Leu Asp Leu Asn Leu Lys Gly Pro Ser Leu Lys Gly Asp
    2370                2375                2380                
Leu Asp Ala Ser Val Pro Ser Met Lys Val His Ala Pro Gly Leu Asn
2385                2390                2395                2400
Leu Ser Gly Val Gly Gly Lys Met Gln Val Gly Gly Asp Gly Val Lys
                2405                2410                2415    
Val Pro Gly Ile Asp Ala Thr Thr Lys Leu Asn Val Gly Ala Pro Asp
            2420                2425                2430        
Val Thr Leu Arg Gly Pro Ser Leu Gln Gly Asp Leu Ala Val Ser Gly
        2435                2440                2445            
Asp Ile Lys Cys Pro Lys Val Ser Val Gly Ala Pro Asp Leu Ser Leu
    2450                2455                2460                
Glu Ala Ser Glu Gly Ser Ile Lys Leu Pro Lys Met Lys Leu Pro Gln
2465                2470                2475                2480
Phe Gly Ile Ser Thr Pro Gly Ser Asp Leu His Val Asn Ala Lys Gly
                2485                2490                2495    
Pro Gln Val Ser Gly Glu Leu Lys Gly Pro Gly Val Asp Val Asn Leu
            2500                2505                2510        
Lys Gly Ser Arg Ile Ser Ala Pro Asn Val Asp Phe Asn Leu Glu Gly
        2515                2520                2525            
Pro Lys Val Lys Gly Ser Leu Gly Ala Thr Gly Glu Ile Lys Gly Pro
    2530                2535                2540                
Thr Val Gly Gly Gly Leu Pro Gly Ile Gly Val Gln Gly Leu Glu Gly
2545                2550                2555                2560
Asn Leu Gln Met Pro Gly Ile Lys Ser Ser Gly Cys Asp Val Asn Leu
                2565                2570                2575    
Pro Gly Val Asn Val Lys Leu Pro Thr Gly Gln Ile Ser Gly Pro Glu
            2580                2585                2590        
Ile Lys Gly Gly Leu Lys Gly Ser Glu Val Gly Phe His Gly Ala Ala
        2595                2600                2605            
Pro Asp Ile Ser Val Lys Gly Pro Ala Phe Asn Met Ala Ser Pro Glu
    2610                2615                2620                
Ser Asp Phe Gly Ile Asn Leu Lys Gly Pro Lys Ile Lys Gly Gly Ala
2625                2630                2635                2640
Asp Val Ser Gly Gly Val Ser Ala Pro Asp Ile Ser Leu Gly Glu Gly
                2645                2650                2655    
His Leu Ser Val Lys Gly Ser Gly Gly Glu Trp Lys Gly Pro Gln Val
            2660                2665                2670        
Ser Ser Ala Leu Asn Leu Asp Thr Ser Lys Phe Ala Gly Gly Leu His
        2675                2680                2685            
Phe Ser Gly Pro Lys Val Glu Gly Gly Val Lys Gly Gly Gln Ile Gly
    2690                2695                2700                
Leu Gln Ala Pro Gly Leu Ser Val Ser Gly Pro Gln Gly His Leu Glu
2705                2710                2715                2720
Ser Gly Ser Gly Lys Val Thr Phe Pro Lys Met Lys Ile Pro Lys Phe
                2725                2730                2735    
Thr Phe Ser Gly Arg Glu Leu Val Gly Arg Glu Met Gly Val Asp Val
            2740                2745                2750        
His Phe Pro Lys Ala Glu Ala Ser Ile Gln Ala Gly Ala Gly Asp Gly
        2755                2760                2765            
Glu Trp Glu Glu Ser Glu Val Lys Leu Lys Lys Ser Lys Ile Lys Met
    2770                2775                2780                
Pro Lys Phe Asn Phe Ser Lys Pro Lys Gly Lys Gly Gly Val Thr Gly
2785                2790                2795                2800
Ser Pro Glu Ala Ser Ile Ser Gly Ser Lys Gly Asp Leu Lys Ser Ser
                2805                2810                2815    
Lys Ala Ser Leu Gly Ser Leu Glu Gly Glu Ala Glu Ala Glu Ala Ser
            2820                2825                2830        
Ser Pro Lys Gly Lys Phe Ser Leu Phe Lys Ser Lys Lys Pro Arg His
        2835                2840                2845            
Arg Ser Asn Ser Phe Ser Asp Glu Arg Glu Phe Ser Gly Pro Ser Thr
    2850                2855                2860                
Pro Thr Gly Thr Leu Glu Phe Glu Gly Gly Glu Val Ser Leu Glu Gly
2865                2870                2875                2880
Gly Lys Val Lys Gly Lys His Gly Lys Leu Lys Phe Gly Thr Phe Gly
                2885                2890                2895    
Gly Leu Gly Ser Lys Ser Lys Gly His Tyr Glu Val Thr Gly Ser Asp
            2900                2905                2910        
Asp Glu Thr Gly Lys Leu Gln Gly Ser Gly Val Ser Leu Ala Ser Lys
        2915                2920                2925            
Lys Ser Arg Leu Ser Ser Ser Ser Ser Asn Asp Ser Gly Asn Lys Val
    2930                2935                2940                
Gly Ile Gln Leu Pro Glu Val Glu Leu Ser Val Ser Thr Lys Lys Glu
2945                2950                2955                2960


<210> 136
<211> 533
<212> PRT
<213> Homo sapiens

<400> 136
Lys Gly Pro Lys Phe Lys Met Pro Asp Leu His Leu Lys Ala Pro Lys
 1               5                  10                  15      
Ile Ser Met Pro Glu Val Asp Leu Asn Leu Lys Gly Pro Lys Met Lys
            20                  25                  30          
Gly Asp Val Asp Val Ser Leu Pro Lys Val Glu Gly Asp Leu Lys Gly
        35                  40                  45              
Pro Glu Val Asp Val Lys Gly Pro Lys Val Asp Ile Asp Val Pro Asp
    50                  55                  60                  
Val Asp Val Gln Gly Pro Asp Trp His Leu Lys Met Pro Lys Val Lys
65                  70                  75                  80  
Met Pro Lys Phe Ser Met Pro Gly Phe Lys Gly Glu Gly Pro Asp Val
                85                  90                  95      
Asp Val Asn Leu Pro Lys Ala Asp Leu Asp Val Ser Gly Pro Lys Val
            100                 105                 110         
Asp Ile Asp Val Pro Asp Val Asn Ile Glu Gly Pro Asp Ala Lys Leu
        115                 120                 125             
Lys Gly Pro Lys Phe Lys Met Pro Glu Met Asn Ile Lys Ala Pro Lys
    130                 135                 140                 
Ile Ser Met Pro Asp Phe Asp Leu His Leu Lys Gly Pro Lys Val Lys
145                 150                 155                 160 
Gly Asp Val Asp Val Ser Leu Pro Lys Val Glu Gly Asp Leu Lys Gly
                165                 170                 175     
Pro Glu Val Asp Ile Lys Gly Pro Lys Val Asp Ile Asp Ala Pro Asp
            180                 185                 190         
Val Asp Val His Gly Pro Asp Trp His Leu Lys Met Pro Lys Val Lys
        195                 200                 205             
Met Pro Lys Phe Ser Met Pro Gly Phe Lys Gly Glu Gly Pro Asp Val
    210                 215                 220                 
Asp Val Thr Leu Pro Lys Ala Asp Ile Glu Ile Ser Gly Pro Lys Val
225                 230                 235                 240 
Asp Ile Asp Ala Pro Asp Val Ser Ile Glu Gly Pro Asp Ala Lys Leu
                245                 250                 255     
Lys Gly Pro Lys Phe Lys Met Pro Glu Met Asn Ile Lys Ala Pro Lys
            260                 265                 270         
Ile Ser Met Pro Asp Ile Asp Phe Asn Leu Lys Gly Pro Lys Val Lys
        275                 280                 285             
Gly Asp Val Asp Val Ser Leu Pro Lys Val Glu Gly Asp Leu Lys Gly
    290                 295                 300                 
Pro Glu Ile Asp Ile Lys Gly Pro Ser Leu Asp Ile Asp Thr Pro Asp
305                 310                 315                 320 
Val Asn Ile Glu Gly Pro Glu Gly Lys Leu Lys Gly Pro Lys Phe Lys
                325                 330                 335     
Met Pro Glu Met Asn Ile Lys Ala Pro Lys Ile Ser Met Pro Asp Phe
            340                 345                 350         
Asp Leu His Leu Lys Gly Pro Lys Val Lys Gly Asp Val Asp Val Ser
        355                 360                 365             
Leu Pro Lys Val Glu Ser Asp Leu Lys Gly Pro Glu Val Asp Ile Glu
    370                 375                 380                 
Gly Pro Glu Gly Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Asp Val
385                 390                 395                 400 
His Phe Lys Ser Pro Gln Ile Ser Met Ser Asp Ile Asp Leu Asn Leu
                405                 410                 415     
Lys Gly Pro Lys Ile Lys Gly Asp Met Asp Ile Ser Val Pro Lys Leu
            420                 425                 430         
Glu Gly Asp Leu Lys Gly Pro Lys Val Asp Val Lys Gly Pro Lys Val
        435                 440                 445             
Gly Ile Asp Thr Pro Asp Ile Asp Ile His Gly Pro Glu Gly Lys Leu
    450                 455                 460                 
Lys Gly Pro Lys Phe Lys Met Pro Asp Leu His Leu Lys Ala Pro Lys
465                 470                 475                 480 
Ile Ser Met Pro Glu Val Asp Leu Asn Leu Lys Gly Pro Lys Val Lys
                485                 490                 495     
Gly Asp Met Asp Ile Ser Leu Pro Lys Val Glu Gly Asp Leu Lys Gly
            500                 505                 510         
Pro Glu Val Asp Ile Arg Asp Pro Lys Val Asp Ile Asp Val Pro Asp
        515                 520                 525             
Val Asp Val Gln Gly
    530             


<210> 137
<211> 161
<212> PRT
<213> Homo sapiens

<400> 137
Cys Tyr Leu Thr Leu Thr Gln Ala Met Lys Met Gly Leu Gly Gly Asn
 1               5                  10                  15      
Pro Tyr Gly Pro Ala Gly Thr Gly Lys Thr Glu Ser Val Lys Ala Leu
            20                  25                  30          
Gly Gly Leu Leu Gly Arg Gln Val Leu Val Phe Asn Cys Asp Glu Gly
        35                  40                  45              
Ile Asp Val Lys Ser Met Gly Arg Ile Phe Val Gly Leu Val Lys Cys
    50                  55                  60                  
Gly Ala Trp Gly Cys Phe Asp Glu Phe Asn Arg Leu Glu Glu Ser Val
65                  70                  75                  80  
Leu Ser Ala Val Ser Met Gln Ile Gln Thr Ile Gln Asp Ala Leu Lys
                85                  90                  95      
Asn His Arg Thr Val Cys Glu Leu Leu Gly Lys Glu Val Glu Val Asn
            100                 105                 110         
Ser Asn Ser Gly Ile Phe Ile Thr Met Asn Pro Ala Gly Lys Gly Tyr
        115                 120                 125             
Gly Gly Arg Gln Lys Leu Pro Asp Asn Leu Lys Gln Leu Phe Arg Pro
    130                 135                 140                 
Val Ala Met Ser His Pro Asp Asn Glu Leu Ile Ala Glu Val Ile Leu
145                 150                 155                 160 
Tyr
    


<210> 138
<211> 142
<212> PRT
<213> Homo sapiens

<400> 138
Met Ala Glu Gln Ser Asp Glu Ala Val Lys Tyr Tyr Thr Leu Glu Glu
 1               5                  10                  15      
Ile Gln Lys His Asn His Ser Lys Ser Thr Trp Leu Ile Leu His His
            20                  25                  30          
Lys Val Tyr Asp Leu Thr Lys Phe Leu Glu Glu His Pro Gly Gly Glu
        35                  40                  45              
Glu Val Leu Arg Glu Gln Ala Gly Gly Asp Ala Thr Glu Asn Phe Glu
    50                  55                  60                  
Asp Val Gly His Ser Thr Asp Ala Arg Glu Met Ser Lys Thr Phe Ile
65                  70                  75                  80  
Ile Gly Glu Leu His Pro Asp Asp Arg Pro Lys Leu Asn Lys Pro Pro
                85                  90                  95      
Glu Pro Leu Lys Ala Val Phe Lys Glu Thr Leu Ile Thr Thr Ile Asp
            100                 105                 110         
Ser Ser Ser Ser Trp Trp Thr Asn Trp Val Ile Pro Ala Ile Ser Ala
        115                 120                 125             
Val Ala Val Ala Leu Met Tyr Arg Leu Tyr Met Ala Glu Asp
    130                 135                 140         


<210> 139
<211> 68
<212> PRT
<213> Homo sapiens

<400> 139
Met Pro Gln Leu Asn Thr Thr Val Trp Pro Thr Met Ile Thr Pro Met
 1               5                  10                  15      
Leu Leu Thr Leu Phe Leu Ile Thr Gln Leu Lys Met Leu Asn Thr Ser
            20                  25                  30          
Tyr His Leu Pro Pro Ser Pro Lys Pro Met Lys Met Lys Asn Tyr Asn
        35                  40                  45              
Lys Pro Trp Glu Pro Lys Trp Thr Lys Ile Cys Ser Leu His Ser Leu
    50                  55                  60                  
Pro Pro Gln Ser
65              


<210> 140
<211> 603
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 22, 40, 54, 99, 100, 101, 110, 135, 146, 162, 168, 200, 201,
202, 233, 277, 301, 302, 303, 363, 364, 379, 402, 403, 404,
407, 472, 497, 503, 504, 505, 547, 559, 583
<223> Xaa = Any Amino Acid

<400> 140
Gly Arg Ala Arg Trp Leu Thr Pro Val Ile Pro Ala Leu Trp Glu Ala
 1               5                  10                  15      
Glu Ala Gly Gly Ser Xaa Gly Gln Glu Ile Glu Thr Ile Leu Ala Asn
            20                  25                  30          
Lys Val Lys Pro Arg Leu Tyr Xaa Lys Tyr Lys Lys Leu Ala Gly Arg
        35                  40                  45              
Gly Gly Gly Arg Leu Xaa Ser Gln Leu Leu Gly Arg Leu Arg Gln Glu
    50                  55                  60                  
Asn Gly Val Asn Pro Gly Ser Gly Ala Cys Ser Glu Pro Arg Leu Arg
65                  70                  75                  80  
His Cys Ser Pro Gln Ser Gly Leu Gly Asp Arg Ala Arg Leu Arg Leu
                85                  90                  95      
Lys Lys Xaa Xaa Xaa Ala Gly Arg Gly Gly Ser Arg Leu Xaa Ser Gln
            100                 105                 110         
His Phe Gly Arg Pro Arg Arg Val Asp His Glu Val Arg Arg Ser Arg
        115                 120                 125             
Pro Ser Trp Leu Thr Arg Xaa Asn Pro Val Ser Thr Lys Asn Thr Lys
    130                 135                 140                 
Asn Xaa Pro Gly Ala Val Ala Gly Ala Cys Ser Pro Ser Tyr Trp Gly
145                 150                 155                 160 
Gly Xaa Gly Arg Arg Met Ala Xaa Thr Arg Glu Ala Glu Leu Ala Val
                165                 170                 175     
Ser Arg Asp Cys Ala Thr Ala Val Arg Ser Pro Ala Trp Ala Thr Glu
            180                 185                 190         
Arg Asp Ser Val Ser Lys Lys Xaa Xaa Xaa Pro Gly Ala Val Ala His
        195                 200                 205             
Ala Cys Asn Pro Ser Thr Leu Gly Gly Arg Gly Gly Trp Ile Met Arg
    210                 215                 220                 
Ser Gly Asp Arg Asp His Pro Gly Xaa Gln Gly Glu Thr Pro Ser Leu
225                 230                 235                 240 
Leu Lys Ile Gln Lys Ile Ser Arg Ala Arg Trp Arg Ala Pro Val Val
                245                 250                 255     
Pro Ala Thr Gly Glu Ala Glu Ala Gly Glu Trp Arg Glu Pro Gly Lys
            260                 265                 270         
Arg Ser Leu Gln Xaa Ala Glu Ile Ala Pro Leu Gln Ser Ala Val Arg
        275                 280                 285             
Pro Gly Arg Gln Ser Glu Thr Pro Ser Gln Lys Lys Xaa Xaa Xaa Phe
    290                 295                 300                 
Phe Leu Arg Arg Ser Leu Ala Leu Ser Pro Arg Pro Asp Cys Gly Leu
305                 310                 315                 320 
Gln Trp Arg Asn Leu Gly Ser Leu Gln Ala Pro Leu Pro Gly Phe Thr
                325                 330                 335     
Pro Phe Ser Cys Leu Ser Leu Pro Ser Ser Trp Asp Tyr Arg Arg Pro
            340                 345                 350         
Pro Pro Arg Pro Ala Asn Phe Leu Tyr Phe Xaa Xaa Arg Arg Gly Phe
        355                 360                 365             
Thr Leu Leu Ala Arg Met Val Ser Ile Ser Xaa Pro His Asp Pro Pro
    370                 375                 380                 
Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val Ser His Arg Ala
385                 390                 395                 400 
Arg Xaa Xaa Xaa Phe Phe Xaa Asp Gly Val Ser Leu Cys Arg Pro Gly
                405                 410                 415     
Arg Thr Ala Asp Cys Ser Gly Ala Ile Ser Ala His Cys Lys Leu Arg
            420                 425                 430         
Phe Pro Gly Ser Arg His Ser Pro Ala Ser Ala Ser Pro Val Ala Gly
        435                 440                 445             
Thr Thr Gly Ala Arg His Arg Ala Arg Leu Ile Phe Cys Ile Phe Ser
    450                 455                 460                 
Arg Asp Gly Val Ser Pro Cys Xaa Pro Gly Trp Ser Arg Ser Pro Asp
465                 470                 475                 480 
Leu Met Ile His Pro Pro Arg Pro Pro Lys Val Leu Gly Leu Gln Ala
                485                 490                 495     
Xaa Ala Thr Ala Pro Gly Xaa Xaa Xaa Phe Phe Glu Thr Glu Ser Arg
            500                 505                 510         
Ser Val Ala Gln Ala Gly Leu Arg Thr Ala Val Ala Gln Ser Arg Leu
        515                 520                 525             
Thr Ala Ser Ser Ala Ser Arg Val His Ala Ile Leu Leu Pro Gln Pro
    530                 535                 540                 
Pro Gln Xaa Leu Gly Leu Gln Ala Pro Ala Thr Ala Pro Gly Xaa Phe
545                 550                 555                 560 
Phe Val Phe Leu Val Glu Thr Gly Phe His Leu Val Ser Gln Asp Gly
                565                 570                 575     
Leu Asp Leu Leu Thr Ser Xaa Ser Thr Arg Leu Gly Leu Pro Lys Cys
            580                 585                 590         
Trp Asp Tyr Arg Arg Glu Pro Pro Arg Pro Ala
        595                 600             


<210> 141
<211> 971
<212> PRT
<213> Homo sapiens

<400> 141
Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser
 1               5                  10                  15      
Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val Phe Lys Arg Phe Lys
            20                  25                  30          
Glu Thr Thr Arg Pro Phe Ser Asn Glu Cys Leu Gly Thr Thr Arg Pro
        35                  40                  45              
Val Val Pro Ile Asp Ser Ser Asp Phe Ala Leu Asp Ile Arg Met Pro
    50                  55                  60                  
Gly Val Thr Pro Lys Gln Ser Asp Thr Tyr Phe Cys Met Ser Met Arg
65                  70                  75                  80  
Ile Pro Val Asp Glu Glu Ala Phe Val Ile Asp Phe Lys Pro Arg Ala
                85                  90                  95      
Ser Met Asp Thr Val His His Met Leu Leu Phe Gly Cys Asn Met Pro
            100                 105                 110         
Ser Ser Thr Gly Ser Tyr Trp Phe Cys Asp Glu Gly Thr Cys Thr Asp
        115                 120                 125             
Lys Ala Asn Ile Leu Tyr Ala Trp Ala Arg Asn Ala Pro Pro Thr Arg
    130                 135                 140                 
Leu Pro Lys Gly Val Gly Phe Arg Val Gly Gly Glu Thr Gly Ser Lys
145                 150                 155                 160 
Tyr Phe Val Leu Gln Val His Tyr Gly Asp Ile Ser Ala Phe Arg Asp
                165                 170                 175     
Asn Asn Lys Asp Cys Ser Gly Val Ser Leu His Leu Thr Arg Leu Pro
            180                 185                 190         
Gln Pro Leu Ile Ala Gly Met Tyr Leu Met Met Ser Val Asp Thr Val
        195                 200                 205             
Ile Pro Ala Gly Glu Lys Val Val Asn Ser Asp Ile Ser Cys His Tyr
    210                 215                 220                 
Lys Asn Tyr Pro Met His Val Phe Ala Tyr Arg Val His Thr His His
225                 230                 235                 240 
Leu Gly Lys Val Val Ser Gly Tyr Arg Val Arg Asn Gly Gln Trp Thr
                245                 250                 255     
Leu Ile Gly Arg Gln Ser Pro Gln Leu Pro Gln Ala Phe Tyr Pro Val
            260                 265                 270         
Gly His Pro Val Asp Val Ser Phe Gly Asp Leu Leu Ala Ala Arg Cys
        275                 280                 285             
Val Phe Thr Gly Glu Gly Arg Thr Glu Ala Thr His Ile Gly Gly Thr
    290                 295                 300                 
Ser Ser Asp Glu Met Cys Asn Leu Tyr Ile Met Tyr Tyr Met Glu Ala
305                 310                 315                 320 
Lys His Ala Val Ser Phe Met Thr Cys Thr Gln Asn Val Ala Pro Asp
                325                 330                 335     
Met Phe Arg Thr Ile Pro Pro Glu Ala Asn Ile Pro Ile Pro Val Lys
            340                 345                 350         
Ser Asp Met Val Met Met His Glu His His Lys Glu Thr Glu Tyr Lys
        355                 360                 365             
Asp Lys Ile Pro Leu Leu Gln Gln Pro Lys Arg Glu Glu Glu Glu Val
    370                 375                 380                 
Leu Asp Gln Gly Asp Phe Tyr Ser Leu Leu Ser Lys Leu Leu Gly Glu
385                 390                 395                 400 
Arg Glu Asp Val Val His Val His Lys Tyr Asn Pro Thr Glu Lys Ala
                405                 410                 415     
Glu Ser Glu Ser Asp Leu Val Ala Glu Ile Ala Asn Val Val Gln Lys
            420                 425                 430         
Lys Asp Leu Gly Arg Ser Asp Ala Arg Glu Gly Ala Glu His Glu Arg
        435                 440                 445             
Gly Asn Ala Ile Leu Val Arg Asp Arg Ile His Lys Phe His Arg Leu
    450                 455                 460                 
Val Ser Thr Leu Arg Pro Pro Glu Ser Arg Val Phe Ser Leu Gln Gln
465                 470                 475                 480 
Pro Pro Pro Gly Glu Gly Thr Trp Glu Pro Glu His Thr Gly Asp Phe
                485                 490                 495     
His Met Glu Glu Ala Leu Asp Trp Pro Gly Val Tyr Leu Leu Pro Gly
            500                 505                 510         
Gln Val Ser Gly Val Ala Leu Asp Pro Lys Asn Asn Leu Val Ile Phe
        515                 520                 525             
His Arg Gly Asp His Val Trp Asp Gly Asn Ser Phe Asp Ser Lys Phe
    530                 535                 540                 
Val Tyr Gln Gln Ile Gly Leu Gly Pro Ile Glu Glu Asp Thr Ile Leu
545                 550                 555                 560 
Val Ile Asp Pro Asn Asn Ala Ala Val Leu Gln Ser Ser Gly Lys Asn
                565                 570                 575     
Leu Phe Tyr Leu Pro His Gly Leu Ser Ile Asp Lys Asp Gly Asn Tyr
            580                 585                 590         
Trp Val Thr Asp Val Ala Leu His Gln Val Phe Lys Leu Asp Pro Asn
        595                 600                 605             
Asn Lys Glu Gly Pro Val Leu Ile Leu Gly Arg Ser Met Gln Pro Gly
    610                 615                 620                 
Ser Asp Gln Asn His Phe Cys Gln Pro Thr Asp Val Ala Val Asp Pro
625                 630                 635                 640 
Gly Thr Gly Ala Ile Tyr Val Ser Asp Gly Tyr Cys Asn Ser Arg Ile
                645                 650                 655     
Val Gln Phe Ser Pro Ser Gly Lys Phe Ile Thr Gln Trp Gly Glu Glu
            660                 665                 670         
Ser Ser Gly Ser Ser Pro Leu Pro Gly Gln Phe Thr Val Pro His Ser
        675                 680                 685             
Leu Ala Leu Val Pro Leu Leu Gly Gln Leu Cys Val Ala Asp Arg Glu
    690                 695                 700                 
Asn Gly Arg Ile Gln Cys Phe Lys Thr Asp Thr Lys Glu Phe Val Arg
705                 710                 715                 720 
Glu Ile Lys His Ser Ser Phe Gly Arg Asn Val Phe Ala Ile Ser Tyr
                725                 730                 735     
Ile Pro Gly Leu Leu Phe Ala Val Asn Gly Lys Pro His Phe Gly Asp
            740                 745                 750         
Gln Glu Pro Val Gln Gly Phe Val Met Asn Phe Ser Asn Gly Glu Ile
        755                 760                 765             
Ile Asp Ile Phe Lys Pro Val Arg Lys His Phe Asp Met Pro His Asp
    770                 775                 780                 
Ile Val Ala Ser Glu Asp Gly Thr Val Tyr Ile Gly Asp Ala His Thr
785                 790                 795                 800 
Asn Thr Val Trp Lys Phe Thr Leu Thr Glu Lys Leu Glu His Arg Ser
                805                 810                 815     
Val Lys Lys Ala Gly Ile Glu Val Gln Glu Ile Lys Glu Ala Val Val
            820                 825                 830         
Glu Thr Lys Met Glu Asn Lys Pro Thr Ser Ser Glu Leu Gln Lys Met
        835                 840                 845             
Gln Glu Lys Gln Lys Leu Ile Lys Glu Pro Gly Ser Gly Val Pro Val
    850                 855                 860                 
Val Leu Ile Thr Thr Leu Leu Val Ile Pro Val Val Val Leu Leu Ala
865                 870                 875                 880 
Ile Ala Ile Phe Ile Arg Trp Lys Lys Ser Arg Ala Phe Gly Asp Ser
                885                 890                 895     
Glu His Lys Leu Glu Thr Ser Ser Gly Arg Val Leu Gly Arg Phe Arg
            900                 905                 910         
Gly Lys Gly Ser Gly Gly Leu Asn Leu Gly Asn Phe Phe Ala Ser Arg
        915                 920                 925             
Lys Gly Tyr Ser Arg Lys Gly Phe Asp Arg Leu Ser Thr Glu Gly Ser
    930                 935                 940                 
Asp Gln Glu Lys Glu Asp Asp Gly Ser Glu Ser Glu Glu Glu Tyr Ser
945                 950                 955                 960 
Ala Pro Leu Pro Ala Leu Ala Pro Ser Ser Ser
                965                 970     


<210> 142
<211> 41
<212> PRT
<213> Homo sapiens

<400> 142
Ile Asp Gly Phe Arg Asp Val Ala Val Ala Phe Thr Gln Lys Glu Trp
 1               5                  10                  15      
Lys Leu Leu Ser Ser Ala Gln Arg Thr Leu Tyr Arg Glu Val Met Leu
            20                  25                  30          
Glu Asn Tyr Ser His Leu Val Ser Leu
        35                  40      


<210> 143
<211> 404
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 184
<223> Xaa = Any Amino Acid

<400> 143
Met Gln Arg Glu Glu Ile Arg Thr Val Lys Arg Gly Gly Gly Ala Ser
 1               5                  10                  15      
Gly Arg Val Pro Gly Leu Arg Ser Gly Asp Gly Arg Pro Arg Arg Val
            20                  25                  30          
Ser Arg Thr Gly Ile Ala Glu Asp Val Asp Pro Leu Pro Gly Leu Pro
        35                  40                  45              
Arg Arg Ala Arg Pro Ser Val Ser Gly Tyr Ala Ala Arg Pro Gly Ala
    50                  55                  60                  
Leu Ala Val Ser Gly Pro Ala Gly Gln Pro Pro Gly Gln Gly Pro Gln
65                  70                  75                  80  
Arg Pro Arg Arg Pro Ala Lys Asp Ala Gln Pro Ala Pro Pro Pro Arg
                85                  90                  95      
Pro Ala Gly Ala Thr Arg Thr Gly Ala Pro Pro Ala Glu Gly Arg Arg
            100                 105                 110         
His Lys Ala Ala Pro His Asn Gly Pro Ala Arg Arg Ser Pro Pro Cys
        115                 120                 125             
Asn Pro Ala Pro Arg Ser Cys Thr His Ile Trp Ala Thr Arg Ala Cys
    130                 135                 140                 
Gly Pro Arg Ala Pro Arg Ser Ser Ala Leu Gly Ser Ala Ser Val Pro
145                 150                 155                 160 
Thr Ala Ser Ser Arg Leu Arg Asp Gly Pro Pro Pro Gly Ala Glu Ile
                165                 170                 175     
Pro Thr Leu Ala Gly Glu Arg Xaa Ala Thr Pro Gly Thr Lys Glu Glu
            180                 185                 190         
Arg Gly Ala Cys Ala Gly Ala Arg Pro Gly Val Ser Leu Arg Cys Gln
        195                 200                 205             
Gly Lys Arg Ala Trp Ala Lys Phe Arg Thr Leu Ala Cys Ala Gly Leu
    210                 215                 220                 
Asp Val Cys Cys Glu Gly Ser Glu Ala Gly Asp Ala Gly Thr Ala Gly
225                 230                 235                 240 
Ser Ser Ala Arg Lys Ala Leu Gly Cys Ser Gly Ala Val Thr Ala Ala
                245                 250                 255     
Leu Ser Pro Pro Gly Pro Ala Ala Arg Leu Leu Ser Gly Leu Ala Gly
            260                 265                 270         
Met Pro Arg Ala Pro Pro Ala Phe Lys Glu Ser Gly Leu Ala Ala Asp
        275                 280                 285             
Ala Tyr Val Ser Leu Gly Ala Gly Arg Ile Pro Trp Val Pro Ala Pro
    290                 295                 300                 
Phe His Val Gly Arg Arg Val Gly Glu Pro Gly Ser Ser Leu Arg Ala
305                 310                 315                 320 
Pro Pro Ala Ala Gly Asp Gly Gly Ala Pro Ala Pro Ala Ala Leu Pro
                325                 330                 335     
Arg Ala Trp Ser Ala Pro Ser Pro Ala Glu Gly Ser Trp Leu Leu Leu
            340                 345                 350         
Ser Pro Arg Pro Val Val Pro Ser Gly Arg Leu Ala Gln Leu Pro Arg
        355                 360                 365             
Leu Ile Pro Ala Pro His Leu Asn Cys Ala Gly Arg Glu Glu Ser Arg
    370                 375                 380                 
Asp Ala Val Leu Pro Ser Val Asp Arg Gly Pro Arg Ser Arg Ile Pro
385                 390                 395                 400 
Trp Glu Ala Ala
                


<210> 144
<211> 76
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 1, 9
<223> Xaa = Any Amino Acid

<400> 144
Xaa Ala Val Tyr Gly Gly Ser Leu Xaa Ser Asn Tyr Tyr Trp Ser Trp
 1               5                  10                  15      
Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Glu Thr Asn
            20                  25                  30          
Tyr Arg Gly Ser Val Lys Tyr Asn Pro Ser Leu Glu Ser Arg Val Thr
        35                  40                  45              
Ile Ser Val Asp Ser Ser Lys Asn Gln Phe Phe Leu Lys Met Ser Ser
    50                  55                  60                  
Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys Ala
65                  70                  75      


<210> 145
<211> 126
<212> PRT
<213> Homo sapiens

<400> 145
Glu Ala Glu Ser Leu Thr Ser Ala Gln Lys Ala Lys Ala Glu Glu Lys
 1               5                  10                  15      
Lys Arg Arg Lys Met Ser Lys Gly Leu Pro Asp Lys Ser Glu Glu Glu
            20                  25                  30          
Lys Ser Thr Met Ala Lys Lys Leu Glu Gln Lys Pro Lys Gly Glu Gly
        35                  40                  45              
Ile Pro Thr Thr Ala Lys Leu Lys Ile Asp Glu Phe Glu Ser Asn Val
    50                  55                  60                  
Asn Glu Val Lys Asp Pro Tyr Pro Ser Ala Asp Phe Pro Gly Asp Asp
65                  70                  75                  80  
Glu Glu Asp Glu Pro Glu Ile Pro Leu Ser Pro Arg Pro Arg Pro Leu
                85                  90                  95      
Ala Glu Leu Gln Leu Lys Glu Lys Ala Val Pro Ile Pro Glu Ala Ser
            100                 105                 110         
Ser Phe Phe Ile Phe Ser Pro Thr Asn Lys Ile Arg Val Leu
        115                 120                 125     


<210> 146
<211> 176
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 11
<223> Xaa = Any Amino Acid

<400> 146
Met Val Glu Ala Asp Cys His Gly Lys Leu Xaa Ile Gly Gly Leu Asn
 1               5                  10                  15      
Arg Glu Ala Asn Glu Lys Val Leu Lys Glu Val Phe Ala Lys His Val
            20                  25                  30          
Leu Leu Ile Lys Gly Arg Thr Ser Lys Ser Arg Asp Phe Val Val Ile
        35                  40                  45              
Ile Phe Glu Asn Ala Ala Asp Ala Lys Asn Ala Ala Arg Asp Met Asn
    50                  55                  60                  
Gly Lys Ser Leu Asp Gly Lys Glu Ile Lys Val Glu Gln Ala Lys Lys
65                  70                  75                  80  
Pro Ser Phe Pro Ser Gly Gly Arg Arg Arg Pro Pro Pro Ser Ser Arg
                85                  90                  95      
Asn Arg Ser Pro Ser Gly Ser Leu Arg Ser Ala Arg Gly Ser Ser Gly
            100                 105                 110         
Gly Thr Arg Pro Trp Leu Pro Ser His Glu Gly His Leu Asp Asp Gly
        115                 120                 125             
Gly Tyr Ala Leu Asp Leu Asn Thr Ser Ser Ser Arg Gly Ala Ile Pro
    130                 135                 140                 
Ile Lys Arg Gly Pro Ser Ser Arg Ser Gly Gly Pro Pro Pro Lys Thr
145                 150                 155                 160 
Ser Ala Pro Ser Ala Met Ala Arg Ser Asn Ser Trp Met Gly Gly Gln
                165                 170                 175     


<210> 147
<211> 284
<212> PRT
<213> Homo sapiens

<400> 147
Leu Lys Gly Thr Val Pro Asp Asp Ala Val Glu Ala Leu Ala Asp Ser
 1               5                  10                  15      
Leu Gly Lys Lys Glu Ala Asp Pro Glu Asp Gly Lys Pro Val Met Asp
            20                  25                  30          
Lys Val Lys Glu Lys Ala Lys Glu Glu Asp Arg Glu Lys Leu Gly Glu
        35                  40                  45              
Lys Glu Glu Thr Ile Pro Pro Asp Tyr Arg Leu Glu Glu Val Lys Asp
    50                  55                  60                  
Lys Asp Gly Lys Pro Leu Leu Pro Lys Glu Ser Lys Glu Gln Leu Pro
65                  70                  75                  80  
Pro Met Ser Glu Asp Phe Leu Leu Asp Ala Leu Ser Glu Asp Phe Ser
                85                  90                  95      
Gly Pro Gln Asn Ala Ser Ser Leu Lys Phe Glu Asp Ala Lys Leu Ala
            100                 105                 110         
Ala Ala Ile Ser Glu Val Val Ser Gln Thr Pro Ala Ser Thr Thr Gln
        115                 120                 125             
Ala Gly Ala Pro Pro Arg Asp Thr Ser Gln Ser Asp Lys Asp Leu Asp
    130                 135                 140                 
Asp Ala Leu Asp Lys Leu Ser Asp Ser Leu Gly Gln Arg Gln Pro Asp
145                 150                 155                 160 
Pro Asp Glu Asn Lys Pro Met Glu Asp Lys Val Lys Glu Lys Ala Lys
                165                 170                 175     
Ala Glu His Arg Asp Lys Leu Gly Glu Arg Asp Asp Thr Ile Pro Pro
            180                 185                 190         
Glu Tyr Arg His Leu Leu Asp Asp Asn Gly Gln Asp Lys Pro Val Lys
        195                 200                 205             
Pro Pro Thr Lys Lys Ser Glu Asp Ser Lys Lys Pro Ala Asp Asp Gln
    210                 215                 220                 
Asp Pro Ile Asp Ala Leu Ser Gly Asp Leu Asp Ser Cys Pro Ser Thr
225                 230                 235                 240 
Thr Glu Thr Ser Gln Asn Thr Ala Lys Asp Lys Cys Lys Lys Ala Ala
                245                 250                 255     
Ser Ser Ser Lys Ala Pro Lys Asn Gly Gly Lys Ala Lys Asp Ser Ala
            260                 265                 270         
Lys Thr Thr Glu Glu Thr Ser Lys Pro Lys Asp Asp
        275                 280                 


<210> 148
<211> 180
<212> PRT
<213> Homo sapiens

<400> 148
Gly Asn Ile Phe Ala Asn Leu Phe Lys Gly Leu Phe Gly Lys Lys Glu
 1               5                  10                  15      
Met Arg Ile Leu Met Val Gly Leu Asp Ala Ala Gly Lys Thr Thr Ile
            20                  25                  30          
Leu Tyr Lys Leu Lys Leu Gly Glu Ile Val Thr Thr Ile Pro Thr Ile
        35                  40                  45              
Gly Phe Asn Val Glu Thr Val Glu Tyr Lys Asn Ile Ser Phe Thr Val
    50                  55                  60                  
Trp Asp Val Gly Gly Gln Asp Lys Ile Arg Pro Leu Trp Arg His Tyr
65                  70                  75                  80  
Phe Gln Asn Thr Gln Gly Leu Ile Phe Val Val Asp Ser Asn Asp Arg
                85                  90                  95      
Glu Arg Val Asn Glu Ala Arg Glu Glu Leu Met Arg Met Leu Ala Glu
            100                 105                 110         
Asp Glu Leu Arg Asp Ala Val Leu Leu Val Phe Ala Asn Lys Gln Asp
        115                 120                 125             
Leu Pro Asn Ala Met Asn Ala Ala Glu Ile Thr Asp Lys Leu Gly Leu
    130                 135                 140                 
His Ser Leu Arg His Arg Asn Trp Tyr Ile Gln Ala Thr Cys Ala Thr
145                 150                 155                 160 
Ser Gly Asp Gly Leu Tyr Glu Gly Leu Asp Trp Leu Ser Asn Gln Leu
                165                 170                 175     
Arg Asn Gln Lys
            180 


<210> 149
<211> 1382
<212> PRT
<213> Homo sapiens

<400> 149
Met Gly Thr Gly Gly Arg Arg Gly Ala Ala Ala Ala Pro Leu Leu Val
 1               5                  10                  15      
Ala Val Ala Ala Leu Leu Leu Gly Ala Ala Gly His Leu Tyr Pro Gly
            20                  25                  30          
Glu Val Cys Pro Gly Met Asp Ile Arg Asn Asn Leu Thr Arg Leu His
        35                  40                  45              
Glu Leu Glu Asn Cys Ser Val Ile Glu Gly His Leu Gln Ile Leu Leu
    50                  55                  60                  
Met Phe Lys Thr Arg Pro Glu Asp Phe Arg Asp Leu Ser Phe Pro Lys
65                  70                  75                  80  
Leu Ile Met Ile Thr Asp Tyr Leu Leu Leu Phe Arg Val Tyr Gly Leu
                85                  90                  95      
Glu Ser Leu Lys Asp Leu Phe Pro Asn Leu Thr Val Ile Arg Gly Ser
            100                 105                 110         
Arg Leu Phe Phe Asn Tyr Ala Leu Val Ile Phe Glu Met Val His Leu
        115                 120                 125             
Lys Glu Leu Gly Leu Tyr Asn Leu Met Asn Ile Thr Arg Gly Ser Val
    130                 135                 140                 
Arg Ile Glu Lys Asn Asn Glu Leu Cys Tyr Leu Ala Thr Ile Asp Trp
145                 150                 155                 160 
Ser Arg Ile Leu Asp Ser Val Glu Asp Asn Tyr Ile Val Leu Asn Lys
                165                 170                 175     
Asp Asp Asn Glu Glu Cys Gly Asp Ile Cys Pro Gly Thr Ala Lys Gly
            180                 185                 190         
Lys Thr Asn Cys Pro Ala Thr Val Ile Asn Gly Gln Phe Val Glu Arg
        195                 200                 205             
Cys Trp Thr His Ser His Cys Gln Lys Val Cys Pro Thr Ile Cys Lys
    210                 215                 220                 
Ser His Gly Cys Thr Ala Glu Gly Leu Cys Cys His Ser Glu Cys Leu
225                 230                 235                 240 
Gly Asn Cys Ser Gln Pro Asp Asp Pro Thr Lys Cys Val Ala Cys Arg
                245                 250                 255     
Asn Phe Tyr Leu Asp Gly Arg Cys Val Glu Thr Cys Pro Pro Pro Tyr
            260                 265                 270         
Tyr His Phe Gln Asp Trp Arg Cys Val Asn Phe Ser Phe Cys Gln Asp
        275                 280                 285             
Leu His His Lys Cys Lys Asn Ser Arg Arg Gln Gly Cys His Gln Tyr
    290                 295                 300                 
Val Ile His Asn Asn Lys Cys Ile Pro Glu Cys Pro Ser Gly Tyr Thr
305                 310                 315                 320 
Met Asn Ser Ser Asn Leu Leu Cys Thr Pro Cys Leu Gly Pro Cys Pro
                325                 330                 335     
Lys Val Cys His Leu Leu Glu Gly Glu Lys Thr Ile Asp Ser Val Thr
            340                 345                 350         
Ser Ala Gln Glu Leu Arg Gly Cys Thr Val Ile Asn Gly Ser Leu Ile
        355                 360                 365             
Ile Asn Ile Arg Gly Gly Asn Asn Leu Ala Ala Glu Leu Glu Ala Asn
    370                 375                 380                 
Leu Gly Leu Ile Glu Glu Ile Ser Gly Tyr Leu Lys Ile Arg Arg Ser
385                 390                 395                 400 
Tyr Ala Leu Val Ser Leu Ser Phe Phe Arg Lys Leu Arg Leu Ile Arg
                405                 410                 415     
Gly Glu Thr Leu Glu Ile Gly Asn Tyr Ser Phe Tyr Ala Leu Asp Asn
            420                 425                 430         
Gln Asn Leu Arg Gln Leu Trp Asp Trp Ser Lys His Asn Leu Thr Ile
        435                 440                 445             
Thr Gln Gly Lys Leu Phe Phe His Tyr Asn Pro Lys Leu Cys Leu Ser
    450                 455                 460                 
Glu Ile His Lys Met Glu Glu Val Ser Gly Thr Lys Gly Arg Gln Glu
465                 470                 475                 480 
Arg Asn Asp Ile Ala Leu Lys Thr Asn Gly Asp Gln Ala Ser Cys Glu
                485                 490                 495     
Asn Glu Leu Leu Lys Phe Ser Tyr Ile Arg Thr Ser Phe Asp Lys Ile
            500                 505                 510         
Leu Leu Arg Trp Glu Pro Tyr Trp Pro Pro Asp Phe Arg Asp Leu Leu
        515                 520                 525             
Gly Phe Met Leu Phe Tyr Lys Glu Ala Pro Tyr Gln Asn Val Thr Glu
    530                 535                 540                 
Phe Asp Gly Gln Asp Ala Cys Gly Ser Asn Ser Trp Thr Val Val Asp
545                 550                 555                 560 
Ile Asp Pro Pro Leu Arg Ser Asn Asp Pro Lys Ser Gln Asn His Pro
                565                 570                 575     
Gly Trp Leu Met Arg Gly Leu Lys Pro Trp Thr Gln Tyr Ala Ile Phe
            580                 585                 590         
Val Lys Thr Leu Val Thr Phe Ser Asp Glu Arg Arg Thr Tyr Gly Ala
        595                 600                 605             
Lys Ser Asp Ile Ile Tyr Val Gln Thr Asp Ala Thr Asn Pro Ser Val
    610                 615                 620                 
Pro Leu Asp Pro Ile Ser Val Ser Asn Ser Ser Ser Gln Ile Ile Leu
625                 630                 635                 640 
Lys Trp Lys Pro Pro Ser Asp Pro Asn Gly Asn Ile Thr His Tyr Leu
                645                 650                 655     
Val Phe Trp Glu Arg Gln Ala Glu Asp Ser Glu Leu Phe Glu Leu Asp
            660                 665                 670         
Tyr Cys Leu Lys Gly Leu Lys Leu Pro Ser Arg Thr Trp Ser Pro Pro
        675                 680                 685             
Phe Glu Ser Glu Asp Ser Gln Lys His Asn Gln Ser Glu Tyr Glu Asp
    690                 695                 700                 
Ser Ala Gly Glu Cys Cys Ser Cys Pro Lys Thr Asp Ser Gln Ile Leu
705                 710                 715                 720 
Lys Glu Leu Glu Glu Ser Ser Phe Arg Lys Thr Phe Glu Asp Tyr Leu
                725                 730                 735     
His Asn Val Val Phe Val Pro Arg Lys Thr Ser Ser Gly Thr Gly Ala
            740                 745                 750         
Glu Asp Pro Arg Pro Ser Arg Lys Arg Arg Ser Leu Gly Asp Val Gly
        755                 760                 765             
Asn Val Thr Val Ala Val Pro Thr Val Ala Ala Phe Pro Asn Thr Ser
    770                 775                 780                 
Ser Thr Ser Val Pro Thr Ser Pro Glu Glu His Arg Pro Phe Glu Lys
785                 790                 795                 800 
Val Val Asn Lys Glu Ser Leu Val Ile Ser Gly Leu Arg His Phe Thr
                805                 810                 815     
Gly Tyr Arg Ile Glu Leu Gln Ala Cys Asn Gln Asp Thr Pro Glu Glu
            820                 825                 830         
Arg Cys Ser Val Ala Ala Tyr Val Ser Ala Arg Thr Met Pro Glu Ala
        835                 840                 845             
Lys Ala Asp Asp Ile Val Gly Pro Val Thr His Glu Ile Phe Glu Asn
    850                 855                 860                 
Asn Val Val His Leu Met Trp Gln Glu Pro Lys Glu Pro Asn Gly Leu
865                 870                 875                 880 
Ile Val Leu Tyr Glu Val Ser Tyr Arg Arg Tyr Gly Asp Glu Glu Leu
                885                 890                 895     
His Leu Cys Val Ser Arg Lys His Phe Ala Leu Glu Arg Gly Cys Arg
            900                 905                 910         
Leu Arg Gly Leu Ser Pro Gly Asn Tyr Ser Val Arg Ile Arg Ala Thr
        915                 920                 925             
Ser Leu Ala Gly Asn Gly Ser Trp Thr Glu Pro Thr Tyr Phe Tyr Val
    930                 935                 940                 
Thr Asp Tyr Leu Asp Val Pro Ser Asn Ile Ala Lys Ile Ile Ile Gly
945                 950                 955                 960 
Pro Leu Ile Phe Val Phe Leu Phe Ser Val Val Ile Gly Ser Ile Tyr
                965                 970                 975     
Leu Phe Leu Arg Lys Arg Gln Pro Asp Gly Pro Leu Gly Pro Leu Tyr
            980                 985                 990         
Ala Ser Ser Asn Pro Glu Tyr Leu Ser Ala Ser Asp Val Phe Pro Cys
        995                 1000                1005            
Ser Val Tyr Val Pro Asp Glu Trp Glu Val Ser Arg Glu Lys Ile Thr
    1010                1015                1020                
Leu Leu Arg Glu Leu Gly Gln Gly Ser Phe Gly Met Val Tyr Glu Gly
1025                1030                1035                1040
Asn Ala Arg Asp Ile Ile Lys Gly Glu Ala Glu Thr Arg Val Ala Val
                1045                1050                1055    
Lys Thr Val Asn Glu Ser Ala Ser Leu Arg Glu Arg Ile Glu Phe Leu
            1060                1065                1070        
Asn Glu Ala Ser Val Met Lys Gly Phe Thr Cys His His Val Val Arg
        1075                1080                1085            
Leu Leu Gly Val Val Ser Lys Gly Gln Pro Thr Leu Val Val Met Glu
    1090                1095                1100                
Leu Met Ala His Gly Asp Leu Lys Ser Tyr Leu Arg Ser Leu Arg Pro
1105                1110                1115                1120
Glu Ala Glu Asn Asn Pro Gly Arg Pro Pro Pro Thr Leu Gln Glu Met
                1125                1130                1135    
Ile Gln Met Ala Ala Glu Ile Ala Asp Gly Met Ala Tyr Leu Asn Ala
            1140                1145                1150        
Lys Lys Phe Val His Arg Asp Leu Ala Ala Arg Asn Cys Met Val Ala
        1155                1160                1165            
His Asp Phe Thr Val Lys Ile Gly Asp Phe Gly Met Thr Arg Asp Ile
    1170                1175                1180                
Tyr Glu Thr Asp Tyr Tyr Arg Lys Gly Gly Lys Gly Leu Leu Pro Val
1185                1190                1195                1200
Arg Trp Met Ala Pro Glu Ser Leu Lys Asp Gly Val Phe Thr Thr Ser
                1205                1210                1215    
Ser Asp Met Trp Ser Phe Gly Val Val Leu Trp Glu Ile Thr Ser Leu
            1220                1225                1230        
Ala Glu Gln Pro Tyr Gln Gly Leu Ser Asn Glu Gln Val Leu Lys Phe
        1235                1240                1245            
Val Met Asp Gly Gly Tyr Leu Asp Gln Pro Asp Asn Cys Pro Glu Arg
    1250                1255                1260                
Val Thr Asp Leu Met Arg Met Cys Trp Gln Phe Asn Pro Lys Met Arg
1265                1270                1275                1280
Pro Thr Phe Leu Glu Ile Val Asn Leu Leu Lys Asp Asp Leu His Pro
                1285                1290                1295    
Ser Phe Pro Glu Val Ser Phe Phe His Ser Glu Glu Asn Lys Ala Pro
            1300                1305                1310        
Glu Ser Glu Glu Leu Glu Met Glu Phe Glu Asp Met Glu Asn Val Pro
        1315                1320                1325            
Leu Asp Arg Ser Ser His Cys Gln Arg Glu Glu Ala Gly Gly Arg Asp
    1330                1335                1340                
Gly Gly Ser Ser Leu Gly Phe Lys Arg Ser Tyr Glu Glu His Ile Pro
1345                1350                1355                1360
Tyr Thr His Met Asn Gly Gly Lys Lys Asn Gly Arg Ile Leu Thr Leu
                1365                1370                1375    
Pro Arg Ser Asn Pro Ser
            1380        


<210> 150
<211> 453
<212> PRT
<213> Homo sapiens

<400> 150
Met Leu Ser Arg Ser Arg Cys Val Ser Arg Ala Phe Ser Ala Pro Leu
 1               5                  10                  15      
Ser Ala Phe Gln Lys Gly Asn Cys Pro Leu Gly Arg Arg Ser Leu Pro
            20                  25                  30          
Gly Val Ser Leu Cys Gln Gly Pro Gly Tyr Pro Asn Ser Arg Lys Val
        35                  40                  45              
Val Ile Asn Asn Ser Val Phe Ser Val Arg Phe Phe Arg Thr Thr Ala
    50                  55                  60                  
Val Cys Lys Asp Asp Leu Val Thr Val Lys Thr Pro Ala Phe Ala Glu
65                  70                  75                  80  
Ser Val Thr Glu Gly Asp Val Arg Trp Glu Lys Ala Val Gly Asp Thr
                85                  90                  95      
Val Ala Glu Asp Glu Val Val Cys Glu Ile Glu Thr Asp Lys Thr Ser
            100                 105                 110         
Val Gln Val Pro Ser Pro Ala Asn Gly Val Ile Glu Ala Leu Leu Val
        115                 120                 125             
Pro Asp Gly Thr Lys Val Glu Gly Gly Thr Pro Leu Phe Thr Leu Arg
    130                 135                 140                 
Lys Thr Gly Ala Ala Pro Ala Lys Ala Lys Pro Ala Glu Ala Pro Ala
145                 150                 155                 160 
Ala Ala Ala Pro Lys Ala Glu Pro Thr Ala Ala Ala Val Pro Pro Pro
                165                 170                 175     
Ala Ala Pro Ile Pro Thr Gln Met Pro Pro Val Pro Ser Pro Ser Gln
            180                 185                 190         
Pro Pro Ser Gly Lys Pro Val Ser Ala Val Lys Pro Thr Val Ala Pro
        195                 200                 205             
Pro Leu Ala Asp Ala Gly Ala Gly Lys Gly Leu Arg Ser Glu His Arg
    210                 215                 220                 
Glu Lys Met Asn Arg Met Arg Gln Arg Ile Ala Gln Arg Leu Lys Glu
225                 230                 235                 240 
Ala Gln Asn Thr Cys Ala Met Leu Thr Thr Phe Asn Glu Ile Asp Met
                245                 250                 255     
Ser Asn Ile Gln Glu Met Arg Ala Arg His Lys Glu Ala Phe Leu Lys
            260                 265                 270         
Lys His Asn Leu Lys Leu Gly Phe Met Ser Ala Phe Val Lys Ala Ser
        275                 280                 285             
Ala Phe Ala Leu Gln Glu Gln Pro Val Val Asn Ala Val Ile Asp Asp
    290                 295                 300                 
Thr Thr Lys Glu Val Val Tyr Arg Asp Tyr Ile Asp Ile Ser Val Ala
305                 310                 315                 320 
Val Ala Thr Pro Arg Gly Leu Val Val Pro Val Ile Arg Asn Val Glu
                325                 330                 335     
Ala Met Asn Phe Ala Asp Ile Glu Arg Thr Ile Thr Glu Leu Gly Glu
            340                 345                 350         
Lys Ala Arg Lys Asn Glu Leu Ala Ile Glu Asp Met Asp Gly Gly Thr
        355                 360                 365             
Phe Thr Ile Ser Asn Gly Gly Val Phe Gly Ser Leu Phe Gly Thr Thr
    370                 375                 380                 
Ile Ile Asn Pro Pro Gln Ser Ala Ile Leu Gly Met His Gly Ile Phe
385                 390                 395                 400 
Asp Arg Pro Val Ala Ile Gly Gly Lys Val Glu Val Arg Pro Met Met
                405                 410                 415     
Tyr Val Ala Leu Thr Tyr Asp His Arg Leu Ile Asp Gly Arg Glu Ala
            420                 425                 430         
Val Thr Phe Leu Arg Lys Ile Lys Ala Ala Val Glu Asp Pro Arg Val
        435                 440                 445             
Leu Leu Leu Asp Leu
    450             


<210> 151
<211> 280
<212> PRT
<213> Homo sapiens

<400> 151
Ser Ala Asn Gly Arg Asp Ala Leu Asp Gly Pro Ala Ala Glu Ala Glu
 1               5                  10                  15      
Pro Glu His Ser Phe Asp Gly Leu Arg Arg Lys Val Ser Ala Gln Arg
            20                  25                  30          
Leu Gln Glu Ala Gly Ile Leu Ser Ala Glu Glu Leu Gln Arg Leu Ala
        35                  40                  45              
Gln Gly His Thr Thr Val Asp Glu Leu Ala Arg Arg Glu Asp Val Arg
    50                  55                  60                  
His Tyr Leu Gln Gly Arg Ser Ser Ile Ala Gly Leu Leu Leu Lys Ala
65                  70                  75                  80  
Thr Asn Glu Lys Leu Ser Val Tyr Ala Ala Leu Gln Arg Gln Leu Leu
                85                  90                  95      
Ser Pro Gly Thr Ala Leu Ile Leu Leu Glu Ala Gln Ala Ala Ser Gly
            100                 105                 110         
Phe Leu Leu Asp Pro Val Arg Asn Arg Arg Leu Thr Val Asn Glu Ala
        115                 120                 125             
Val Lys Glu Gly Val Val Gly Pro Glu Leu His His Lys Leu Leu Ser
    130                 135                 140                 
Ala Glu Arg Ala Val Thr Gly Tyr Lys Asp Pro Tyr Thr Val Gln Gln
145                 150                 155                 160 
Ile Ser Leu Phe Gln Ala Met Gln Lys Gly Leu Ile Val Arg Glu His
                165                 170                 175     
Gly Ile Arg Leu Leu Glu Ala Gln Ile Ala Thr Gly Gly Val Ile Asp
            180                 185                 190         
Pro Val His Ser His Arg Val Pro Val Asp Val Ala Tyr Arg Arg Gly
        195                 200                 205             
Tyr Phe Asp Glu Glu Met Asn Arg Val Leu Ala Asp Pro Ser Asp Asp
    210                 215                 220                 
Thr Lys Gly Phe Phe Asp Pro Asn Thr His Glu Asn Leu Thr Tyr Leu
225                 230                 235                 240 
Gln Leu Leu Glu Arg Cys Val Glu Asp Pro Glu Thr Gly Leu Phe Leu
                245                 250                 255     
Leu Pro Leu Thr Asp Lys Ala Ala Lys Gly Gly Glu Leu Val Tyr Thr
            260                 265                 270         
Asp Ser Glu Ala Arg Asp Val Pro
        275                 280 


<210> 152
<211> 462
<212> PRT
<213> Homo sapiens

<400> 152
Gly Ser Ser Ala Arg Ala Arg Phe Leu Leu Arg Phe Cys Arg Ala Arg
 1               5                  10                  15      
Leu Ser Gly Thr Gly Leu Ala Met Asp Pro Leu Ser Glu Leu Gln Asp
            20                  25                  30          
Asp Leu Thr Leu Asp Asp Thr Ser Glu Ala Leu Asn Gln Leu Lys Leu
        35                  40                  45              
Ala Ser Ile Asp Glu Lys Asn Trp Pro Ser Asp Glu Met Pro Asp Phe
    50                  55                  60                  
Pro Lys Ser Asp Asp Ser Lys Ser Ser Ser Pro Glu Leu Val Thr His
65                  70                  75                  80  
Leu Lys Trp Asp Asp Pro Tyr Tyr Asp Ile Ala Arg His Gln Ile Val
                85                  90                  95      
Glu Val Ala Gly Asp Asp Lys Tyr Gly Arg Lys Ile Ile Val Phe Ser
            100                 105                 110         
Ala Cys Arg Met Pro Pro Ser His Gln Leu Asp His Ser Lys Leu Leu
        115                 120                 125             
Gly Tyr Leu Lys His Thr Leu Asp Gln Tyr Val Glu Ser Asp Tyr Thr
    130                 135                 140                 
Leu Leu Tyr Leu His His Gly Leu Thr Ser Asp Asn Lys Pro Ser Leu
145                 150                 155                 160 
Ser Trp Leu Arg Asp Ala Tyr Arg Glu Phe Asp Arg Lys Tyr Lys Lys
                165                 170                 175     
Asn Ile Lys Ala Leu Tyr Ile Val His Pro Thr Met Phe Ile Lys Thr
            180                 185                 190         
Leu Leu Ile Leu Phe Lys Pro Leu Ile Ser Phe Lys Phe Gly Gln Lys
        195                 200                 205             
Ile Phe Tyr Val Asn Tyr Leu Ser Glu Leu Ser Glu His Val Lys Leu
    210                 215                 220                 
Glu Gln Leu Gly Ile Pro Arg Gln Val Leu Lys Tyr Asp Asp Phe Leu
225                 230                 235                 240 
Lys Ser Thr Gln Lys Ser Pro Ala Thr Ala Pro Lys Pro Met Pro Pro
                245                 250                 255     
Arg Pro Pro Leu Pro Asn Gln Gln Phe Gly Val Ser Leu Gln His Leu
            260                 265                 270         
Gln Glu Lys Asn Pro Glu Gln Glu Pro Ile Pro Ile Val Leu Arg Glu
        275                 280                 285             
Thr Val Ala Tyr Leu Gln Ala His Ala Leu Thr Thr Glu Gly Ile Phe
    290                 295                 300                 
Arg Arg Ser Ala Asn Thr Gln Val Val Arg Glu Val Gln Gln Lys Tyr
305                 310                 315                 320 
Asn Met Gly Leu Pro Val Asp Phe Asp Gln Tyr Asn Glu Leu His Leu
                325                 330                 335     
Pro Ala Val Ile Leu Lys Thr Phe Leu Arg Glu Leu Pro Glu Pro Leu
            340                 345                 350         
Leu Thr Phe Asp Leu Tyr Pro His Val Val Gly Phe Leu Asn Ile Asp
        355                 360                 365             
Glu Ser Gln Arg Val Pro Ala Thr Leu Gln Val Leu Gln Thr Leu Pro
    370                 375                 380                 
Glu Glu Asn Tyr Gln Val Leu Arg Phe Leu Thr Ala Phe Leu Val Gln
385                 390                 395                 400 
Ile Ser Ala His Ser Asp Gln Asn Lys Met Thr Asn Thr Asn Leu Ala
                405                 410                 415     
Val Val Phe Gly Pro Asn Leu Leu Trp Ala Lys Asp Ala Ala Ile Thr
            420                 425                 430         
Leu Lys Ala Ile Asn Pro Ile Asn Thr Phe Thr Lys Phe Leu Leu Asp
        435                 440                 445             
His Gln Gly Glu Leu Phe Pro Ser Pro Asp Pro Ser Gly Leu
    450                 455                 460         


<210> 153
<211> 135
<212> PRT
<213> Homo sapiens

<400> 153
Met Arg Arg Val Phe Val Gln Gln Asp Asn Gly Glu Leu Thr Leu Trp
 1               5                  10                  15      
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala
            20                  25                  30          
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        35                  40                  45              
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    50                  55                  60                  
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
65                  70                  75                  80  
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                85                  90                  95      
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Leu
            100                 105                 110         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        115                 120                 125             
Ser Phe Asn Arg Gly Glu Cys
    130                 135 


<210> 154
<211> 1581
<212> PRT
<213> Homo sapiens

<400> 154
Lys Asn Cys Ala Val Cys Asn Cys Gly Gly Gly Pro Cys Asp Ser Val
 1               5                  10                  15      
Thr Gly Glu Cys Leu Glu Glu Gly Phe Glu Pro Pro Thr Gly Cys Asp
            20                  25                  30          
Lys Cys Val Trp Asp Leu Thr Asp Asp Leu Arg Leu Ala Ala Leu Ser
        35                  40                  45              
Ile Glu Glu Gly Lys Ser Gly Val Leu Ser Val Ser Ser Gly Ala Ala
    50                  55                  60                  
Ala His Arg His Val Asn Glu Ile Asn Ala Thr Ile Tyr Leu Leu Lys
65                  70                  75                  80  
Thr Lys Leu Ser Glu Arg Glu Asn Gln Tyr Ala Leu Arg Lys Ile Gln
                85                  90                  95      
Ile Asn Asn Ala Glu Asn Thr Met Lys Ser Leu Leu Ser Asp Val Glu
            100                 105                 110         
Glu Leu Val Glu Lys Glu Asn Gln Ala Ser Arg Lys Gly Gln Leu Val
        115                 120                 125             
Gln Lys Glu Ser Met Asp Thr Ile Asn His Ala Ser Gln Leu Val Glu
    130                 135                 140                 
Gln Ala His Asp Met Arg Asp Lys Ile Gln Glu Ile Asn Asn Lys Met
145                 150                 155                 160 
Leu Tyr Tyr Gly Glu Glu His Glu Leu Ser Pro Lys Glu Ile Ser Glu
                165                 170                 175     
Lys Leu Val Leu Ala Gln Lys Met Leu Glu Glu Ile Arg Ser Arg Gln
            180                 185                 190         
Pro Phe Phe Thr Gln Arg Glu Leu Val Asp Glu Glu Ala Asp Glu Ala
        195                 200                 205             
Tyr Glu Leu Leu Ser Gln Ala Glu Ser Trp Gln Arg Leu His Asn Glu
    210                 215                 220                 
Thr Arg Thr Leu Phe Pro Val Val Leu Glu Gln Leu Asp Asp Tyr Asn
225                 230                 235                 240 
Ala Lys Leu Ser Asp Leu Gln Glu Ala Leu Asp Gln Ala Leu Asn His
                245                 250                 255     
Val Arg Asp Ala Glu Asp Met Asn Arg Ala Thr Ala Ala Arg Gln Arg
            260                 265                 270         
Asp His Glu Lys Gln Gln Glu Arg Val Arg Glu Gln Met Glu Val Val
        275                 280                 285             
Asn Met Ser Leu Ser Thr Ser Ala Asp Ser Leu Thr Thr Pro Arg Leu
    290                 295                 300                 
Thr Leu Ser Glu Leu Asp Asp Ile Ile Lys Asn Ala Ser Gly Ile Tyr
305                 310                 315                 320 
Ala Glu Ile Asp Gly Ala Lys Ser Glu Leu Gln Val Lys Leu Ser Asn
                325                 330                 335     
Leu Ser Asn Leu Ser His Asp Leu Val Gln Glu Ala Ile Asp His Ala
            340                 345                 350         
Gln Asp Leu Gln Gln Glu Ala Asn Glu Leu Ser Arg Lys Leu His Ser
        355                 360                 365             
Ser Asp Met Asn Gly Leu Val Gln Lys Ala Leu Asp Ala Ser Asn Val
    370                 375                 380                 
Tyr Glu Asn Ile Val Asn Tyr Val Ser Glu Ala Asn Glu Thr Ala Glu
385                 390                 395                 400 
Phe Ala Leu Asn Thr Thr Asp Arg Ile Tyr Asp Ala Val Ser Gly Ile
                405                 410                 415     
Asp Thr Gln Ile Ile Tyr His Lys Asp Glu Ser Glu Asn Leu Leu Asn
            420                 425                 430         
Gln Ala Arg Glu Leu Gln Ala Lys Ala Glu Ser Ser Ser Asp Glu Ala
        435                 440                 445             
Val Ala Asp Thr Ser Arg Arg Val Gly Gly Ala Leu Ala Arg Lys Ser
    450                 455                 460                 
Ala Leu Lys Thr Arg Leu Ser Asp Ala Val Lys Gln Leu Gln Ala Ala
465                 470                 475                 480 
Glu Arg Gly Asp Ala Gln Gln Arg Leu Gly Gln Ser Arg Leu Ile Thr
                485                 490                 495     
Glu Glu Ala Asn Arg Thr Thr Met Glu Val Gln Gln Ala Thr Ala Pro
            500                 505                 510         
Met Ala Asn Asn Leu Thr Asn Trp Ser Gln Asn Leu Gln His Phe Asp
        515                 520                 525             
Ser Ser Ala Tyr Asn Thr Ala Val Asn Ser Ala Arg Asp Ala Val Arg
    530                 535                 540                 
Asn Leu Thr Glu Val Val Pro Gln Leu Leu Asp Gln Leu Arg Thr Val
545                 550                 555                 560 
Glu Gln Lys Arg Pro Ala Ser Asn Val Ser Ala Ser Ile Gln Arg Ile
                565                 570                 575     
Arg Glu Leu Ile Ala Gln Thr Arg Ser Val Ala Ser Lys Ile Gln Val
            580                 585                 590         
Ser Met Met Phe Asp Gly Gln Ser Ala Val Glu Val His Ser Arg Thr
        595                 600                 605             
Ser Met Asp Asp Leu Lys Ala Phe Thr Ser Leu Ser Leu Tyr Met Lys
    610                 615                 620                 
Pro Pro Val Lys Arg Pro Glu Leu Thr Glu Thr Ala Asp Gln Phe Ile
625                 630                 635                 640 
Leu Tyr Leu Gly Ser Lys Asn Ala Lys Lys Glu Tyr Met Gly Leu Ala
                645                 650                 655     
Ile Lys Asn Asp Asn Leu Val Tyr Val Tyr Asn Leu Gly Thr Lys Asp
            660                 665                 670         
Val Glu Ile Pro Leu Asp Ser Lys Pro Val Ser Ser Trp Pro Ala Tyr
        675                 680                 685             
Phe Ser Ile Val Lys Ile Glu Arg Val Gly Lys His Gly Lys Val Phe
    690                 695                 700                 
Leu Thr Val Pro Ser Leu Ser Ser Thr Ala Glu Glu Lys Phe Ile Lys
705                 710                 715                 720 
Lys Gly Glu Phe Ser Gly Asp Asp Ser Leu Leu Asp Leu Asp Pro Glu
                725                 730                 735     
Asp Thr Val Phe Tyr Val Gly Gly Val Pro Ser Asn Phe Lys Leu Pro
            740                 745                 750         
Thr Ser Leu Asn Leu Pro Gly Phe Val Gly Cys Leu Glu Leu Ala Thr
        755                 760                 765             
Leu Asn Asn Asp Val Ile Ser Leu Tyr Asn Phe Lys His Ile Tyr Asn
    770                 775                 780                 
Met Asp Pro Ser Thr Ser Val Pro Cys Ala Arg Asp Lys Leu Ala Phe
785                 790                 795                 800 
Thr Gln Ser Arg Ala Ala Ser Tyr Phe Phe Asp Gly Ser Gly Tyr Ala
                805                 810                 815     
Val Val Arg Asp Ile Thr Arg Arg Gly Lys Phe Gly Gln Val Thr Arg
            820                 825                 830         
Phe Asp Ile Glu Val Arg Thr Pro Ala Asp Asn Gly Leu Ile Leu Leu
        835                 840                 845             
Met Val Asn Gly Ser Met Phe Phe Arg Leu Glu Met Arg Asn Gly Tyr
    850                 855                 860                 
Leu His Val Phe Tyr Asp Phe Gly Phe Ser Ser Gly Arg Val His Leu
865                 870                 875                 880 
Glu Asp Thr Leu Lys Lys Ala Gln Ile Asn Asp Ala Lys Tyr His Glu
                885                 890                 895     
Ile Ser Ile Ile Tyr His Asn Asp Lys Lys Met Ile Leu Val Val Asp
            900                 905                 910         
Arg Arg His Val Lys Ser Met Asp Asn Glu Lys Met Lys Ile Pro Phe
        915                 920                 925             
Thr Asp Ile Tyr Ile Gly Gly Ala Pro Pro Glu Ile Leu Gln Ser Arg
    930                 935                 940                 
Ala Leu Arg Ala His Leu Pro Leu Asp Ile Asn Phe Arg Gly Cys Met
945                 950                 955                 960 
Lys Gly Phe Gln Phe Gln Lys Lys Asp Phe Asn Leu Leu Glu Gln Thr
                965                 970                 975     
Glu Thr Leu Gly Val Gly Tyr Gly Cys Pro Glu Asp Ser Leu Ile Ser
            980                 985                 990         
Arg Arg Ala Tyr Phe Asn Gly Gln Ser Phe Ile Ala Ser Ile Gln Lys
        995                 1000                1005            
Ile Ser Phe Phe Asp Gly Phe Glu Gly Gly Phe Asn Phe Arg Thr Leu
    1010                1015                1020                
Gln Pro Asn Gly Leu Leu Phe Tyr Tyr Ala Ser Gly Ser Asp Val Phe
1025                1030                1035                1040
Ser Ile Ser Leu Asp Asn Gly Thr Val Ile Met Asp Val Lys Gly Ile
                1045                1050                1055    
Lys Val Gln Ser Val Asp Lys Gln Tyr Asn Asp Gly Leu Ser His Phe
            1060                1065                1070        
Val Ile Ser Ser Val Ser Pro Thr Arg Tyr Glu Leu Ile Val Asp Lys
        1075                1080                1085            
Ser Arg Val Gly Ser Lys Asn Pro Thr Lys Gly Lys Ile Glu Gln Thr
    1090                1095                1100                
Gln Ala Ser Glu Lys Lys Phe Tyr Phe Gly Gly Ser Pro Ile Ser Ala
1105                1110                1115                1120
Gln Tyr Ala Asn Phe Thr Gly Cys Ile Ser Asn Ala Tyr Phe Thr Arg
                1125                1130                1135    
Val Asp Arg Asp Val Glu Val Glu Asp Phe Gln Arg Tyr Thr Glu Lys
            1140                1145                1150        
Val His Thr Ser Leu Tyr Glu Cys Pro Ile Glu Ser Ser Pro Leu Phe
        1155                1160                1165            
Leu Leu His Lys Lys Gly Lys Asn Leu Ser Lys Pro Lys Ala Ser Gln
    1170                1175                1180                
Asn Lys Lys Gly Gly Lys Ser Lys Asp Ala Pro Ser Trp Asp Pro Val
1185                1190                1195                1200
Ala Leu Lys Leu Pro Glu Arg Asn Thr Pro Arg Asn Ser His Cys His
                1205                1210                1215    
Leu Ser Asn Ser Pro Arg Ala Ile Glu His Ala Tyr Gln Tyr Gly Gly
            1220                1225                1230        
Thr Ala Asn Ser Arg Gln Glu Phe Glu His Leu Lys Gly Asp Phe Gly
        1235                1240                1245            
Ala Lys Ser Gln Phe Ser Ile Arg Leu Arg Thr Arg Ser Ser His Gly
    1250                1255                1260                
Met Ile Phe Tyr Val Ser Asp Gln Glu Glu Asn Asp Phe Met Thr Leu
1265                1270                1275                1280
Phe Leu Ala His Gly Arg Leu Val Tyr Met Phe Asn Val Gly His Lys
                1285                1290                1295    
Lys Leu Lys Ile Arg Ser Gln Glu Lys Tyr Asn Asp Gly Leu Trp His
            1300                1305                1310        
Asp Val Ile Phe Ile Arg Glu Arg Ser Ser Gly Arg Leu Val Ile Asp
        1315                1320                1325            
Gly Leu Arg Val Leu Glu Glu Ser Leu Pro Pro Thr Glu Ala Thr Trp
    1330                1335                1340                
Lys Ile Lys Gly Pro Ile Tyr Leu Gly Gly Val Ala Pro Gly Lys Ala
1345                1350                1355                1360
Val Lys Asn Val Gln Ile Asn Ser Ile Tyr Ser Phe Ser Gly Cys Leu
                1365                1370                1375    
Ser Asn Leu Gln Leu Asn Gly Ala Ser Ile Thr Ser Ala Ser Gln Thr
            1380                1385                1390        
Phe Ser Val Thr Pro Cys Phe Glu Gly Pro Met Glu Thr Gly Thr Tyr
        1395                1400                1405            
Phe Ser Thr Glu Gly Gly Tyr Val Val Leu Asp Glu Ser Phe Asn Ile
    1410                1415                1420                
Gly Leu Lys Phe Glu Ile Ala Phe Glu Val Arg Pro Arg Ser Ser Ser
1425                1430                1435                1440
Gly Thr Leu Val His Gly His Ser Val Asn Gly Glu Tyr Leu Asn Val
                1445                1450                1455    
His Met Lys Asn Gly Gln Val Ile Val Lys Val Asn Asn Gly Ile Arg
            1460                1465                1470        
Asp Phe Ser Thr Ser Val Thr Pro Lys Gln Ser Leu Cys Asp Gly Arg
        1475                1480                1485            
Trp His Arg Ile Thr Val Ile Arg Asp Ser Asn Val Val Gln Leu Asp
    1490                1495                1500                
Val Asp Ser Glu Val Asn His Val Val Gly Pro Leu Asn Pro Lys Pro
1505                1510                1515                1520
Ile Asp His Arg Glu Pro Val Phe Val Gly Gly Val Pro Glu Ser Leu
                1525                1530                1535    
Leu Thr Pro Arg Leu Ala Pro Ser Lys Pro Phe Thr Gly Cys Ile Arg
            1540                1545                1550        
His Phe Val Ile Asp Gly His Pro Val Ser Phe Ser Lys Ala Ala Leu
        1555                1560                1565            
Val Ser Gly Ala Val Ser Ile Asn Ser Cys Pro Ala Ala
    1570                1575                1580    


<210> 155
<211> 1234
<212> PRT
<213> Homo sapiens

<400> 155
Met Ala Gly Ala Gln Pro Gly Val His Ala Leu Gln Leu Glu Pro Pro
 1               5                  10                  15      
Thr Val Val Glu Thr Leu Arg Arg Gly Ser Lys Phe Ile Lys Trp Asp
            20                  25                  30          
Glu Glu Thr Ser Ser Arg Asn Leu Val Thr Leu Arg Val Asp Pro Asn
        35                  40                  45              
Gly Phe Phe Leu Tyr Trp Thr Gly Pro Asn Met Glu Val Asp Thr Leu
    50                  55                  60                  
Asp Ile Ser Ser Ile Arg Asp Thr Arg Thr Gly Arg Tyr Ala Arg Leu
65                  70                  75                  80  
Pro Lys Asp Pro Lys Ile Arg Glu Val Leu Gly Phe Gly Gly Pro Asp
                85                  90                  95      
Ala Arg Leu Glu Glu Lys Leu Met Thr Val Val Ser Gly Pro Asp Pro
            100                 105                 110         
Val Asn Thr Val Phe Leu Asn Phe Met Ala Val Gln Asp Asp Thr Ala
        115                 120                 125             
Lys Val Trp Ser Glu Glu Leu Phe Lys Leu Ala Met Asn Ile Leu Ala
    130                 135                 140                 
Gln Asn Ala Ser Arg Asn Thr Phe Leu Arg Lys Ala Tyr Thr Lys Leu
145                 150                 155                 160 
Lys Leu Gln Val Asn Gln Asp Gly Arg Ile Pro Val Lys Asn Ile Leu
                165                 170                 175     
Lys Met Phe Ser Ala Asp Lys Lys Arg Val Glu Thr Ala Leu Glu Ser
            180                 185                 190         
Cys Gly Leu Lys Phe Asn Arg Ser Glu Ser Ile Arg Pro Asp Glu Phe
        195                 200                 205             
Ser Leu Glu Ile Phe Glu Arg Phe Leu Asn Lys Leu Cys Leu Arg Pro
    210                 215                 220                 
Asp Ile Asp Lys Ile Leu Leu Glu Ile Gly Ala Lys Gly Lys Pro Tyr
225                 230                 235                 240 
Leu Thr Leu Glu Gln Leu Met Asp Phe Ile Asn Gln Lys Gln Arg Asp
                245                 250                 255     
Pro Arg Leu Asn Glu Val Leu Tyr Pro Pro Leu Arg Pro Ser Gln Ala
            260                 265                 270         
Arg Leu Leu Ile Glu Lys Tyr Glu Pro Asn Gln Gln Phe Leu Glu Arg
        275                 280                 285             
Asp Gln Met Ser Met Glu Gly Phe Ser Arg Tyr Leu Gly Gly Glu Glu
    290                 295                 300                 
Asn Gly Ile Leu Pro Leu Glu Ala Leu Asp Leu Ser Thr Asp Met Thr
305                 310                 315                 320 
Gln Pro Leu Ser Ala Tyr Phe Ile Asn Ser Ser His Asn Thr Tyr Leu
                325                 330                 335     
Thr Ala Gly Gln Leu Ala Gly Thr Ser Ser Val Glu Met Tyr Arg Gln
            340                 345                 350         
Ala Leu Leu Trp Gly Cys Arg Cys Val Glu Leu Asp Val Trp Lys Gly
        355                 360                 365             
Arg Pro Pro Glu Glu Glu Pro Phe Ile Thr His Gly Phe Thr Met Thr
    370                 375                 380                 
Thr Glu Val Pro Leu Arg Asp Val Leu Glu Ala Ile Ala Glu Thr Ala
385                 390                 395                 400 
Phe Lys Thr Ser Pro Tyr Pro Val Ile Leu Ser Phe Glu Asn His Val
                405                 410                 415     
Asp Ser Ala Lys Gln Gln Ala Lys Met Ala Glu Tyr Cys Arg Ser Ile
            420                 425                 430         
Phe Gly Asp Ala Leu Leu Ile Glu Pro Leu Asp Lys Tyr Pro Leu Ala
        435                 440                 445             
Pro Gly Val Pro Leu Pro Ser Pro Gln Asp Leu Met Gly Arg Ile Leu
    450                 455                 460                 
Val Lys Asn Lys Lys Arg His Arg Pro Ser Ala Gly Gly Pro Asp Ser
465                 470                 475                 480 
Ala Gly Arg Lys Arg Pro Leu Glu Gln Ser Asn Ser Ala Leu Ser Glu
                485                 490                 495     
Ser Ser Ala Ala Thr Glu Pro Ser Ser Pro Gln Leu Gly Ser Pro Ser
            500                 505                 510         
Ser Asp Ser Cys Pro Gly Leu Ser Asn Gly Glu Glu Val Gly Leu Glu
        515                 520                 525             
Lys Pro Ser Leu Glu Pro Gln Lys Ser Leu Gly Asp Glu Gly Leu Asn
    530                 535                 540                 
Arg Gly Pro Tyr Val Leu Gly Pro Ala Asp Arg Glu Asp Glu Glu Glu
545                 550                 555                 560 
Asp Glu Glu Glu Glu Glu Gln Thr Asp Pro Lys Lys Pro Thr Thr Asp
                565                 570                 575     
Glu Gly Thr Ala Ser Ser Glu Val Asn Ala Thr Glu Glu Met Ser Thr
            580                 585                 590         
Leu Val Asn Tyr Ile Glu Pro Val Lys Phe Lys Ser Phe Glu Ala Ala
        595                 600                 605             
Arg Lys Arg Asn Lys Cys Phe Glu Met Ser Ser Phe Val Glu Thr Lys
    610                 615                 620                 
Ala Met Glu Gln Leu Thr Lys Ser Pro Met Glu Phe Val Glu Tyr Asn
625                 630                 635                 640 
Lys Gln Gln Leu Ser Arg Ile Tyr Pro Lys Gly Thr Arg Val Asp Ser
                645                 650                 655     
Ser Asn Tyr Met Pro Gln Leu Phe Trp Asn Val Gly Cys Gln Leu Val
            660                 665                 670         
Ala Leu Asn Phe Gln Thr Leu Asp Val Ala Met Gln Leu Asn Ala Gly
        675                 680                 685             
Val Phe Glu Tyr Asn Gly Arg Ser Gly Tyr Leu Leu Lys Pro Glu Phe
    690                 695                 700                 
Met Arg Arg Pro Asp Lys Ser Phe Asp Pro Phe Thr Glu Val Ile Val
705                 710                 715                 720 
Asp Gly Ile Val Ala Asn Ala Leu Arg Val Lys Val Ile Ser Gly Gln
                725                 730                 735     
Phe Leu Ser Asp Arg Lys Val Gly Ile Tyr Val Glu Val Asp Met Phe
            740                 745                 750         
Gly Leu Pro Val Asp Thr Arg Arg Lys Tyr Arg Thr Arg Thr Ser Gln
        755                 760                 765             
Gly Asn Ser Phe Asn Pro Val Trp Asp Glu Glu Pro Phe Asp Phe Pro
    770                 775                 780                 
Lys Val Val Leu Pro Thr Leu Ala Ser Leu Arg Ile Ala Ala Phe Glu
785                 790                 795                 800 
Glu Gly Gly Lys Phe Val Gly His Arg Ile Leu Pro Val Ser Ala Ile
                805                 810                 815     
Arg Ser Gly Tyr His Tyr Val Cys Leu Arg Asn Glu Ala Asn Gln Pro
            820                 825                 830         
Leu Cys Leu Pro Ala Leu Leu Ile Tyr Thr Glu Ala Ser Asp Tyr Ile
        835                 840                 845             
Pro Asp Asp His Gln Asp Tyr Ala Glu Ala Leu Ile Asn Pro Ile Lys
    850                 855                 860                 
His Val Ser Leu Met Asp Gln Arg Ala Arg Gln Leu Ala Ala Leu Ile
865                 870                 875                 880 
Glu Glu Ser Glu Ala Gln Ala Gly Gln Glu Thr Cys Gln Asp Thr Gln
                885                 890                 895     
Ser Gln Gln Leu Gly Ser Gln Pro Ser Ser Asn Pro Thr Pro Ser Pro
            900                 905                 910         
Leu Asp Ala Ser Pro Arg Arg Pro Pro Gly Pro Thr Thr Ser Pro Ala
        915                 920                 925             
Ser Thr Ser Leu Ser Ser Pro Gly Gln Arg Asp Asp Leu Ile Ala Ser
    930                 935                 940                 
Ile Leu Ser Glu Val Ala Pro Thr Pro Leu Asp Glu Leu Arg Gly His
945                 950                 955                 960 
Lys Ala Leu Val Lys Leu Arg Ser Arg Gln Glu Arg Asp Leu Arg Glu
                965                 970                 975     
Leu Arg Lys Lys His Gln Arg Lys Ala Val Thr Leu Thr Arg Arg Leu
            980                 985                 990         
Leu Asp Gly Leu Ala Gln Ala Gln Ala Glu Gly Arg Cys Arg Leu Arg
        995                 1000                1005            
Pro Gly Ala Leu Gly Gly Ala Ala Asp Val Glu Asp Thr Lys Glu Gly
    1010                1015                1020                
Glu Asp Glu Ala Lys Arg Tyr Gln Glu Phe Gln Asn Arg Gln Val Gln
1025                1030                1035                1040
Ser Leu Leu Glu Leu Arg Glu Ala Gln Val Asp Ala Glu Ala Gln Arg
                1045                1050                1055    
Arg Leu Glu His Leu Arg Gln Ala Leu Gln Arg Leu Arg Glu Val Val
            1060                1065                1070        
Leu Asp Ala Asn Thr Thr Gln Phe Lys Arg Leu Lys Glu Met Asn Glu
        1075                1080                1085            
Ser Trp Pro Ser Trp Pro Arg Ser Val Arg Ser Ser Gly Arg Gly Ser
    1090                1095                1100                
Pro Arg Arg Ser Ala Gly Ala Cys Trp Ala Arg Cys Arg Arg Gly Glu
1105                1110                1115                1120
Leu Thr Glu Ile Asn Arg Arg His Ile Thr Glu Ser Val Asn Ser Ile
                1125                1130                1135    
Arg Arg Leu Glu Glu Ala Gln Lys Gln Arg His Asp Arg Leu Val Ala
            1140                1145                1150        
Gly Gln Gln Gln Val Leu Gln Gln Leu Ala Glu Glu Glu Pro Lys Leu
        1155                1160                1165            
Leu Ala Gln Leu Ala Gln Glu Cys Gln Glu Gln Arg Ala Arg Leu Pro
    1170                1175                1180                
Gln Glu Ile Arg Arg Ser Leu Leu Gly Glu Met Pro Glu Gly Leu Gly
1185                1190                1195                1200
Asp Gly Pro Leu Val Ala Cys Ala Ser Asn Gly His Ala Pro Gly Ser
                1205                1210                1215    
Ser Gly His Leu Ser Gly Ala Asp Ser Glu Ser Gln Glu Glu Asn Thr
            1220                1225                1230        
Gln Leu
        


<210> 156
<211> 539
<212> PRT
<213> Homo sapiens

<400> 156
Met Ala Ala Ala Leu Arg Val Ala Ala Val Gly Ala Arg Leu Ser Val
 1               5                  10                  15      
Leu Ala Ser Gly Leu Arg Ala Ala Val Arg Ser Leu Cys Ser Gln Ala
            20                  25                  30          
Thr Ser Val Asn Glu Arg Ile Glu Asn Lys Arg Arg Thr Ala Leu Leu
        35                  40                  45              
Gly Gly Gly Gln Arg Arg Ile Asp Ala His Asp Lys Arg Gly Lys Leu
    50                  55                  60                  
Thr Ala Arg Glu Arg Ile Ser Leu Leu Leu Asp Pro Gly Ser Phe Val
65                  70                  75                  80  
Glu Ser Asp Met Phe Val Glu His Arg Cys Ala Asp Phe Gly Met Ala
                85                  90                  95      
Ala Asp Lys Asn Lys Phe Pro Gly Asp Ser Val Val Thr Gly Arg Gly
            100                 105                 110         
Arg Ile Asn Gly Arg Leu Val Tyr Val Phe Ser Gln Asp Phe Thr Val
        115                 120                 125             
Phe Gly Gly Ser Leu Ser Gly Ala His Ala Gln Lys Ile Cys Lys Ile
    130                 135                 140                 
Met Asp Gln Ala Ile Thr Val Gly Ala Pro Val Ile Gly Leu Asn Asp
145                 150                 155                 160 
Ser Gly Gly Ala Arg Ile Gln Glu Gly Val Glu Ser Leu Ala Gly Tyr
                165                 170                 175     
Ala Asp Ile Phe Leu Arg Asn Val Thr Ala Ser Gly Val Ile Pro Gln
            180                 185                 190         
Ile Ser Leu Ile Met Gly Pro Cys Ala Gly Gly Ala Val Tyr Ser Pro
        195                 200                 205             
Ala Leu Thr Asp Phe Thr Phe Met Val Lys Asp Thr Ser Tyr Leu Phe
    210                 215                 220                 
Ile Thr Gly Pro Asp Val Val Lys Ser Val Thr Asn Glu Asp Val Thr
225                 230                 235                 240 
Gln Glu Glu Leu Gly Gly Ala Lys Thr His Thr Thr Met Ser Gly Val
                245                 250                 255     
Ala His Arg Ala Phe Glu Asn Asp Val Asp Ala Leu Cys Asn Leu Arg
            260                 265                 270         
Asp Phe Phe Asn Tyr Leu Pro Leu Ser Ser Gln Asp Pro Ala Pro Val
        275                 280                 285             
Arg Glu Cys His Asp Pro Ser Asp Arg Leu Val Pro Glu Leu Asp Thr
    290                 295                 300                 
Ile Val Pro Leu Glu Ser Thr Lys Ala Tyr Asn Met Val Asp Ile Ile
305                 310                 315                 320 
His Ser Val Val Asp Glu Arg Glu Phe Phe Glu Ile Met Pro Asn Tyr
                325                 330                 335     
Ala Lys Asn Ile Ile Val Gly Phe Ala Arg Met Asn Gly Arg Thr Val
            340                 345                 350         
Gly Ile Val Gly Asn Gln Pro Lys Val Ala Ser Gly Cys Leu Asp Ile
        355                 360                 365             
Asn Ser Ser Val Lys Gly Ala Arg Phe Val Arg Phe Cys Asp Ala Phe
    370                 375                 380                 
Asn Ile Pro Leu Ile Thr Phe Val Asp Val Pro Gly Phe Leu Pro Gly
385                 390                 395                 400 
Thr Ala Gln Glu Tyr Gly Gly Ile Ile Arg His Gly Ala Lys Leu Leu
                405                 410                 415     
Tyr Ala Phe Ala Glu Ala Thr Val Pro Lys Val Thr Val Ile Thr Arg
            420                 425                 430         
Lys Ala Tyr Gly Gly Ala Tyr Asp Val Met Ser Ser Lys His Leu Cys
        435                 440                 445             
Gly Asp Thr Asn Tyr Ala Trp Pro Thr Ala Glu Ile Ala Val Met Gly
    450                 455                 460                 
Ala Lys Gly Ala Val Glu Ile Ile Phe Lys Gly His Glu Asn Val Glu
465                 470                 475                 480 
Ala Ala Gln Ala Glu Tyr Ile Glu Lys Phe Ala Asn Pro Phe Pro Ala
                485                 490                 495     
Ala Val Arg Gly Phe Val Asp Asp Ile Ile Gln Pro Ser Ser Thr Arg
            500                 505                 510         
Ala Arg Ile Cys Cys Asp Leu Asp Val Leu Ala Ser Lys Lys Val Gln
        515                 520                 525             
Arg Pro Trp Arg Lys His Ala Asn Ile Pro Leu
    530                 535                 


<210> 157
<211> 539
<212> PRT
<213> Homo sapiens

<400> 157
Met Ala Ala Ala Leu Arg Val Ala Ala Val Gly Ala Arg Leu Ser Val
 1               5                  10                  15      
Leu Ala Ser Gly Leu Arg Ala Ala Val Arg Ser Leu Cys Ser Gln Ala
            20                  25                  30          
Thr Ser Val Asn Glu Arg Ile Glu Asn Lys Arg Arg Thr Ala Leu Leu
        35                  40                  45              
Gly Gly Gly Gln Arg Arg Ile Asp Ala His Asp Lys Arg Gly Lys Leu
    50                  55                  60                  
Thr Ala Arg Glu Arg Ile Ser Leu Leu Leu Asp Pro Gly Ser Phe Val
65                  70                  75                  80  
Glu Ser Asp Met Phe Val Glu His Arg Cys Ala Asp Phe Gly Met Ala
                85                  90                  95      
Ala Asp Lys Asn Lys Phe Pro Gly Asp Ser Val Val Thr Gly Arg Gly
            100                 105                 110         
Arg Ile Asn Gly Arg Leu Val Tyr Val Phe Ser Gln Asp Phe Thr Val
        115                 120                 125             
Phe Gly Gly Ser Leu Ser Gly Ala His Ala Gln Lys Ile Cys Lys Ile
    130                 135                 140                 
Met Asp Gln Ala Ile Thr Val Gly Ala Pro Val Ile Gly Leu Asn Asp
145                 150                 155                 160 
Ser Gly Gly Ala Arg Ile Gln Glu Gly Val Glu Ser Leu Ala Gly Tyr
                165                 170                 175     
Ala Asp Ile Phe Leu Arg Asn Val Thr Ala Ser Gly Val Ile Pro Gln
            180                 185                 190         
Ile Ser Leu Ile Met Gly Pro Cys Ala Gly Gly Ala Val Tyr Ser Pro
        195                 200                 205             
Ala Leu Thr Asp Phe Thr Phe Met Val Lys Asp Thr Ser Tyr Leu Phe
    210                 215                 220                 
Ile Thr Gly Pro Asp Val Val Lys Ser Val Thr Asn Glu Asp Val Thr
225                 230                 235                 240 
Gln Glu Glu Leu Gly Gly Ala Lys Thr His Thr Thr Met Ser Gly Val
                245                 250                 255     
Ala His Arg Ala Phe Glu Asn Asp Val Asp Ala Leu Cys Asn Leu Arg
            260                 265                 270         
Asp Phe Phe Asn Tyr Leu Pro Leu Ser Ser Gln Asp Pro Ala Pro Val
        275                 280                 285             
Arg Glu Cys His Asp Pro Ser Asp Arg Leu Val Pro Glu Leu Asp Thr
    290                 295                 300                 
Ile Val Pro Leu Glu Ser Thr Lys Ala Tyr Asn Met Val Asp Ile Ile
305                 310                 315                 320 
His Ser Val Val Asp Glu Arg Glu Phe Phe Glu Ile Met Pro Asn Tyr
                325                 330                 335     
Ala Lys Asn Ile Ile Val Gly Phe Ala Arg Met Asn Gly Arg Thr Val
            340                 345                 350         
Gly Ile Val Gly Asn Gln Pro Lys Val Ala Ser Gly Cys Leu Asp Ile
        355                 360                 365             
Asn Ser Ser Val Lys Gly Ala Arg Phe Val Arg Phe Cys Asp Ala Phe
    370                 375                 380                 
Asn Ile Pro Leu Ile Thr Phe Val Asp Val Pro Gly Phe Leu Pro Gly
385                 390                 395                 400 
Thr Ala Gln Glu Tyr Gly Gly Ile Ile Arg His Gly Ala Lys Leu Leu
                405                 410                 415     
Tyr Ala Phe Ala Glu Ala Thr Val Pro Lys Val Thr Val Ile Thr Arg
            420                 425                 430         
Lys Ala Tyr Gly Gly Ala Tyr Asp Val Met Ser Ser Lys His Leu Cys
        435                 440                 445             
Gly Asp Thr Asn Tyr Ala Trp Pro Thr Ala Glu Ile Ala Val Met Gly
    450                 455                 460                 
Ala Lys Gly Ala Val Glu Ile Ile Phe Lys Gly His Glu Asn Val Glu
465                 470                 475                 480 
Ala Ala Gln Ala Glu Tyr Ile Glu Lys Phe Ala Asn Pro Phe Pro Ala
                485                 490                 495     
Ala Val Arg Gly Phe Val Asp Asp Ile Ile Gln Pro Ser Ser Thr Arg
            500                 505                 510         
Ala Arg Ile Cys Cys Asp Leu Asp Val Leu Ala Ser Lys Lys Val Gln
        515                 520                 525             
Arg Pro Trp Arg Lys His Ala Asn Ile Pro Leu
    530                 535                 


<210> 158
<211> 1017
<212> PRT
<213> Homo sapiens

<400> 158
Val Glu Lys Gly Glu Phe Ala Leu Arg Leu Ser Ser Thr Gln Glu Glu
 1               5                  10                  15      
Val His Gln Leu Arg Arg Gly Ile Glu Lys Leu Arg Val Arg Ile Glu
            20                  25                  30          
Ala Asp Glu Lys Lys Gln Leu His Ile Ala Glu Lys Leu Lys Glu Arg
        35                  40                  45              
Asp Gly Glu Asn Asp Ser Leu Lys Asp Lys Val Glu Asn Leu Glu Arg
    50                  55                  60                  
Glu Leu Gln Met Ser Glu Glu Asn Gln Glu Leu Val Ile Leu Asp Ala
65                  70                  75                  80  
Glu Asn Ser Lys Ala Glu Val Glu Thr Leu Lys Thr Gln Ile Glu Glu
                85                  90                  95      
Met Ala Arg Ser Leu Lys Val Phe Glu Leu Asp Leu Val Thr Leu Arg
            100                 105                 110         
Ser Glu Lys Glu Asn Leu Thr Lys Gln Ile Gln Glu Lys Gln Gly Gln
        115                 120                 125             
Leu Ser Glu Leu Asp Lys Leu Leu Ser Ser Phe Lys Ser Gln Leu Glu
    130                 135                 140                 
Glu Lys Glu Gln Ala Glu Ile Gln Ile Lys Glu Glu Ser Lys Thr Ala
145                 150                 155                 160 
Val Glu Met Leu Gln Asn Gln Leu Lys Glu Leu Asn Glu Ala Val Ala
                165                 170                 175     
Ala Leu Cys Gly Asp Gln Glu Ile Met Lys Ala Thr Glu Gln Ser Leu
            180                 185                 190         
Asp Pro Pro Ile Glu Glu Glu His Gln Leu Arg Asn Ser Ile Glu Lys
        195                 200                 205             
Leu Arg Ala Arg Leu Glu Ala Asp Glu Lys Lys Gln Leu Cys Val Leu
    210                 215                 220                 
Gln Gln Leu Lys Glu Ser Glu His His Ala Asp Leu Leu Lys Gly Arg
225                 230                 235                 240 
Val Glu Asn Leu Glu Arg Glu Leu Glu Ile Ala Arg Thr Asn Gln Glu
                245                 250                 255     
His Ala Ala Leu Glu Ala Glu Asn Ser Lys Gly Glu Val Glu Thr Leu
            260                 265                 270         
Lys Ala Lys Ile Glu Gly Met Thr Gln Ser Leu Arg Gly Leu Glu Leu
        275                 280                 285             
Asp Val Val Thr Ile Arg Ser Glu Lys Glu Asp Leu Thr Asn Glu Leu
    290                 295                 300                 
Gln Lys Glu Gln Glu Arg Ile Ser Glu Leu Glu Ile Ile Asn Ser Ser
305                 310                 315                 320 
Phe Glu Asn Ile Leu Gln Glu Lys Glu Gln Glu Lys Val Gln Met Lys
                325                 330                 335     
Glu Lys Ser Ser Thr Ala Met Glu Met Leu Gln Thr Gln Leu Lys Ser
            340                 345                 350         
Ser Met Arg Glu Trp Gln Pro Cys Ile Met Thr Lys Lys Pro Val Ser
        355                 360                 365             
Ala Lys Glu Gln Asn Leu Ser Ser Gln Val Glu Cys Leu Glu Leu Glu
    370                 375                 380                 
Lys Ala Gln Leu Leu Gln Gly Leu Asp Glu Ala Lys Asn Asn Tyr Ile
385                 390                 395                 400 
Val Leu Gln Ser Ser Val Asn Gly Leu Ile Gln Glu Val Glu Asp Gly
                405                 410                 415     
Lys Gln Lys Leu Glu Lys Lys Asp Glu Glu Ile Ser Arg Leu Lys Asn
            420                 425                 430         
Gln Ile Gln Asp Gln Glu Gln Leu Val Ser Lys Leu Ser Gln Val Glu
        435                 440                 445             
Gly Glu His Gln Leu Trp Lys Glu Gln Asn Leu Glu Leu Arg Asn Leu
    450                 455                 460                 
Thr Val Glu Leu Glu Gln Lys Ile Gln Val Leu Gln Ser Lys Asn Ala
465                 470                 475                 480 
Ser Leu Gln Asp Thr Leu Glu Val Leu Gln Ser Ser Tyr Lys Asn Leu
                485                 490                 495     
Glu Asn Glu Leu Glu Leu Thr Lys Met Asp Lys Met Ser Phe Val Glu
            500                 505                 510         
Lys Val Asn Lys Met Thr Ala Lys Glu Thr Glu Leu Gln Arg Glu Met
        515                 520                 525             
His Glu Met Ala Gln Lys Thr Ala Glu Leu Gln Glu Glu Leu Ser Gly
    530                 535                 540                 
Glu Lys Asn Arg Leu Ala Gly Glu Leu Gln Leu Leu Leu Glu Glu Ile
545                 550                 555                 560 
Lys Ser Ser Lys Asp Gln Leu Lys Glu Leu Thr Leu Glu Asn Ser Glu
                565                 570                 575     
Leu Lys Lys Ser Leu Asp Cys Met His Lys Asp Gln Val Glu Lys Glu
            580                 585                 590         
Gly Lys Val Arg Glu Glu Ile Ala Glu Tyr Gln Leu Arg Leu His Glu
        595                 600                 605             
Ala Glu Lys Lys His Gln Ala Leu Leu Leu Asp Thr Asn Lys Gln Tyr
    610                 615                 620                 
Glu Val Glu Ile Gln Thr Tyr Arg Glu Lys Leu Thr Ser Lys Glu Glu
625                 630                 635                 640 
Cys Leu Ser Ser Gln Lys Leu Glu Ile Asp Leu Leu Lys Ser Ser Lys
                645                 650                 655     
Glu Glu Leu Asn Asn Ser Leu Lys Ala Thr Thr Gln Ile Leu Glu Glu
            660                 665                 670         
Leu Lys Lys Thr Lys Met Asp Asn Leu Lys Tyr Val Asn Gln Leu Lys
        675                 680                 685             
Lys Glu Asn Glu Arg Ala Gln Gly Lys Met Lys Leu Leu Ile Lys Ser
    690                 695                 700                 
Cys Lys Gln Leu Glu Glu Glu Lys Glu Ile Leu Gln Lys Glu Leu Ser
705                 710                 715                 720 
Gln Leu Gln Ala Ala Gln Glu Lys Gln Lys Thr Gly Thr Val Met Asp
                725                 730                 735     
Thr Lys Val Asp Glu Leu Thr Thr Glu Ile Lys Glu Leu Lys Glu Thr
            740                 745                 750         
Leu Glu Glu Lys Thr Lys Glu Ala Asp Glu Tyr Leu Asp Lys Tyr Cys
        755                 760                 765             
Ser Leu Leu Ile Ser His Glu Lys Leu Glu Lys Ala Lys Glu Met Leu
    770                 775                 780                 
Glu Thr Gln Val Ala His Leu Cys Ser Gln Gln Ser Lys Gln Asp Ser
785                 790                 795                 800 
Arg Gly Ser Pro Leu Leu Gly Pro Val Val Pro Gly Pro Ser Pro Ile
                805                 810                 815     
Pro Ser Val Thr Glu Lys Arg Leu Ser Ser Gly Gln Asn Lys Ala Ser
            820                 825                 830         
Gly Lys Arg Gln Arg Ser Ser Gly Ile Trp Glu Asn Gly Gly Gly Pro
        835                 840                 845             
Thr Pro Ala Thr Pro Glu Ser Phe Ser Lys Lys Ser Lys Lys Ala Val
    850                 855                 860                 
Met Ser Gly Ile His Pro Ala Glu Asp Thr Glu Gly Thr Glu Phe Glu
865                 870                 875                 880 
Pro Glu Gly Leu Pro Glu Val Val Lys Lys Gly Phe Ala Asp Ile Pro
                885                 890                 895     
Thr Gly Lys Thr Ser Pro Tyr Ile Leu Arg Arg Thr Thr Met Ala Thr
            900                 905                 910         
Arg Thr Ser Pro Arg Leu Ala Ala Gln Lys Leu Ala Leu Ser Pro Leu
        915                 920                 925             
Ser Leu Gly Lys Glu Asn Leu Ala Glu Ser Ser Lys Pro Thr Ala Gly
    930                 935                 940                 
Gly Ser Arg Ser Gln Lys Val Lys Val Ala Gln Arg Ser Pro Val Asp
945                 950                 955                 960 
Ser Gly Thr Ile Leu Arg Glu Pro Thr Thr Lys Ser Val Pro Val Asn
                965                 970                 975     
Asn Leu Pro Glu Arg Ser Pro Thr Asp Ser Pro Arg Glu Gly Leu Arg
            980                 985                 990         
Val Lys Arg Gly Arg Leu Val Pro Ser Pro Lys Ala Gly Leu Glu Ser
        995                 1000                1005            
Lys Gly Ser Glu Asn Cys Lys Val Gln
    1010                1015        


<210> 159
<211> 505
<212> PRT
<213> Homo sapiens

<400> 159
Met Arg Leu Arg Arg Leu Ala Leu Phe Pro Gly Val Ala Leu Leu Leu
 1               5                  10                  15      
Ala Ala Ala Arg Leu Ala Ala Ala Ser Asp Val Leu Glu Leu Thr Asp
            20                  25                  30          
Asp Asn Phe Glu Ser Arg Ile Ser Asp Thr Gly Ser Ala Gly Leu Met
        35                  40                  45              
Leu Val Glu Phe Phe Ala Pro Trp Cys Gly His Cys Lys Arg Leu Ala
    50                  55                  60                  
Pro Glu Tyr Glu Ala Ala Ala Thr Arg Leu Lys Gly Ile Val Pro Leu
65                  70                  75                  80  
Ala Lys Val Asp Cys Thr Ala Asn Thr Asn Thr Cys Asn Lys Tyr Gly
                85                  90                  95      
Val Ser Gly Tyr Pro Thr Leu Lys Ile Phe Arg Asp Gly Glu Glu Ala
            100                 105                 110         
Gly Ala Tyr Asp Gly Pro Arg Thr Ala Asp Gly Ile Val Ser His Leu
        115                 120                 125             
Lys Lys Gln Ala Gly Pro Ala Ser Val Pro Leu Arg Thr Glu Glu Glu
    130                 135                 140                 
Phe Lys Lys Phe Ile Ser Asp Lys Asp Ala Ser Ile Val Gly Phe Phe
145                 150                 155                 160 
Asp Asp Ser Phe Ser Glu Ala His Ser Glu Phe Leu Lys Ala Ala Ser
                165                 170                 175     
Asn Leu Arg Asp Asn Tyr Arg Phe Ala His Thr Asn Val Glu Ser Leu
            180                 185                 190         
Val Asn Glu Tyr Asp Asp Asn Gly Glu Gly Ile Ile Leu Phe Arg Pro
        195                 200                 205             
Ser His Leu Thr Asn Lys Phe Glu Asp Lys Thr Val Ala Tyr Thr Glu
    210                 215                 220                 
Pro Lys Met Thr Ser Gly Lys Ile Lys Lys Phe Ile Gln Gly Asn Ile
225                 230                 235                 240 
Phe Gly Ile Cys Pro His Met Thr Glu Asp Asn Lys Asp Leu Ile Gln
                245                 250                 255     
Gly Lys Asp Leu Leu Ile Ala Tyr Tyr Asp Val Asp Tyr Glu Lys Asn
            260                 265                 270         
Ala Lys Gly Ser Asn Tyr Trp Arg Asn Arg Val Met Met Val Ala Lys
        275                 280                 285             
Lys Phe Leu Asp Ala Gly His Lys Leu Asn Phe Ala Val Ala Ser Arg
    290                 295                 300                 
Lys Thr Phe Ser His Glu Leu Ser Asp Phe Gly Leu Glu Ser Thr Ala
305                 310                 315                 320 
Gly Glu Ile Pro Val Val Ala Ile Arg Thr Ala Lys Gly Glu Lys Phe
                325                 330                 335     
Val Met Gln Glu Glu Phe Ser Arg Asp Gly Lys Ala Leu Glu Arg Phe
            340                 345                 350         
Leu Gln Asp Tyr Phe Asp Gly Asn Leu Lys Arg Tyr Leu Lys Ser Glu
        355                 360                 365             
Pro Ile Pro Glu Ser Asn Asp Gly Pro Val Lys Val Val Val Ala Glu
    370                 375                 380                 
Asn Phe Asp Glu Ile Val Asn Asn Glu Asn Lys Asp Val Leu Ile Glu
385                 390                 395                 400 
Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Asn Leu Glu Pro Lys Tyr
                405                 410                 415     
Lys Glu Leu Gly Glu Lys Leu Ser Lys Asp Pro Asn Ile Val Ile Ala
            420                 425                 430         
Lys Met Asp Ala Thr Ala Asn Asp Val Pro Ser Pro Tyr Glu Val Arg
        435                 440                 445             
Gly Phe Pro Thr Ile Tyr Phe Ser Pro Ala Asn Lys Lys Leu Asn Pro
    450                 455                 460                 
Lys Lys Tyr Glu Gly Gly Arg Glu Leu Ser Asp Phe Ile Ser Tyr Leu
465                 470                 475                 480 
Gln Arg Glu Ala Thr Asn Pro Pro Val Ile Gln Glu Glu Lys Pro Lys
                485                 490                 495     
Lys Lys Lys Lys Ala Gln Glu Asp Leu
            500                 505 


<210> 160
<211> 124
<212> PRT
<213> Homo sapiens

<400> 160
Met Ser Ala Arg Gly Pro Ala Ile Gly Ile Asp Leu Gly Thr Thr Tyr
 1               5                  10                  15      
Ser Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn
            20                  25                  30          
Asp Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr
        35                  40                  45              
Glu Arg Leu Ile Gly Ala Ala Lys Asn Gln Val Ala Met Asn Pro Thr
    50                  55                  60                  
Asn Thr Ile Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe Glu Asp
65                  70                  75                  80  
Ala Thr Val Gln Ser Asp Met Lys His Trp Pro Phe Arg Val Val Ser
                85                  90                  95      
Glu Gly Gly Lys Pro Lys Val Gln Val Glu Tyr Lys Gly Glu Thr Lys
            100                 105                 110         
Thr Phe Phe Pro Glu Glu Ile Ser Ser Met Val Leu
        115                 120                 


<210> 161
<211> 230
<212> PRT
<213> Homo sapiens

<400> 161
Met Ala Trp Lys Ser Gly Gly Ala Ser His Ser Glu Leu Ile His Asn
 1               5                  10                  15      
Leu Arg Lys Asn Gly Ile Ile Lys Thr Asp Lys Val Phe Glu Tyr Met
            20                  25                  30          
Leu Ala Thr Asp Arg Ser His Tyr Ala Lys Cys Asn Pro Tyr Met Asp
        35                  40                  45              
Ser Pro Gln Ser Ile Gly Phe Gln Ala Thr Ile Ser Ala Pro His Met
    50                  55                  60                  
His Ala Tyr Ala Leu Glu Leu Leu Phe Asp Gln Leu His Glu Gly Ala
65                  70                  75                  80  
Lys Ala Leu Asp Val Gly Ser Gly Ser Gly Ile Leu Thr Ala Cys Phe
                85                  90                  95      
Ala Arg Met Val Gly Cys Thr Gly Lys Val Ile Gly Ile Asp His Ile
            100                 105                 110         
Lys Glu Leu Val Asp Asp Ser Val Asn Asn Val Arg Lys Asp Asp Pro
        115                 120                 125             
Thr Leu Leu Ser Ser Gly Arg Val Gln Leu Val Val Gly Asp Gly Arg
    130                 135                 140                 
Met Gly Tyr Ala Glu Glu Ala Pro Tyr Asp Ala Ile His Val Gly Ala
145                 150                 155                 160 
Ala Ala Pro Val Val Pro Gln Ala Leu Ile Asp Gln Leu Lys Pro Gly
                165                 170                 175     
Gly Arg Leu Ile Leu Pro Val Gly Pro Ala Gly Gly Asn Gln Met Leu
            180                 185                 190         
Glu Gln Tyr Asp Lys Leu Gln Asp Gly Ser Ile Lys Met Lys Pro Leu
        195                 200                 205             
Met Gly Val Ile Tyr Val Pro Leu Thr Asp Lys Glu Lys Gln Trp Ser
    210                 215                 220                 
Arg Trp Lys Asp Glu Leu
225                 230 


<210> 162
<211> 279
<212> PRT
<213> Homo sapiens

<400> 162
Met Leu Pro Leu Leu Arg Cys Val Pro Arg Val Leu Gly Ser Ser Val
 1               5                  10                  15      
Ala Gly Leu Arg Ala Ala Ala Arg Leu Ala Phe Pro Ala Ala Pro Ala
            20                  25                  30          
Ala His Pro Val Cys Thr Arg Pro Phe Arg Val Leu Ser Val Arg Ala
        35                  40                  45              
Gly Ser Glu Arg Arg Pro Ala Ser Cys Gly Ser Arg Thr Leu Arg Cys
    50                  55                  60                  
Gly Cys Gly Cys Gly Ser Leu His Thr Asp Gly Asp Lys Ala Phe Val
65                  70                  75                  80  
Asp Phe Leu Ser Asp Glu Ile Lys Glu Glu Arg Lys Ile Gln Lys His
                85                  90                  95      
Lys Thr Leu Pro Lys Met Ser Gly Gly Trp Glu Leu Glu Leu Asn Gly
            100                 105                 110         
Thr Glu Ala Lys Leu Val Arg Lys Val Ala Gly Glu Lys Ile Thr Val
        115                 120                 125             
Thr Phe Asn Ile Asn Asn Ser Ile Pro Pro Thr Phe Asp Gly Glu Glu
    130                 135                 140                 
Glu Pro Ser Gln Gly Gln Lys Val Glu Glu Gln Glu Pro Glu Leu Thr
145                 150                 155                 160 
Ser Thr Pro Asn Phe Val Val Glu Val Ile Lys Asn Asp Asp Gly Lys
                165                 170                 175     
Lys Ala Leu Val Leu Asp Cys His Tyr Pro Glu Asp Glu Val Gly Gln
            180                 185                 190         
Glu Asp Glu Ala Glu Ser Asp Ile Phe Ser Ile Arg Glu Val Ser Phe
        195                 200                 205             
Gln Ser Thr Gly Glu Ser Glu Trp Lys Asp Thr Asn Tyr Thr Leu Asn
    210                 215                 220                 
Thr Asp Ser Leu Asp Trp Ala Leu Tyr Asp His Leu Met Asp Phe Leu
225                 230                 235                 240 
Ala Asp Arg Gly Val Asp Asn Thr Phe Ala Asp Glu Leu Val Glu Leu
                245                 250                 255     
Ser Thr Ala Leu Glu His Gln Glu Tyr Ile Thr Phe Leu Glu Asp Leu
            260                 265                 270         
Lys Ser Phe Val Lys Ser Gln
        275                 


<210> 163
<211> 458
<212> PRT
<213> Homo sapiens

<400> 163
Thr Glu Gln Lys Val Ser Asp Phe Tyr Asp Ile Glu Glu Arg Leu Gly
 1               5                  10                  15      
Ser Gly Lys Phe Gly Gln Val Phe Arg Leu Val Glu Lys Lys Thr Arg
            20                  25                  30          
Lys Val Trp Ala Gly Lys Phe Phe Lys Ala Tyr Ser Ala Lys Glu Lys
        35                  40                  45              
Glu Asn Ile Arg Gln Glu Ile Ser Ile Met Asn Cys Leu His His Pro
    50                  55                  60                  
Lys Leu Val Gln Cys Val Asp Ala Phe Glu Glu Lys Ala Asn Ile Val
65                  70                  75                  80  
Met Val Leu Glu Ile Val Ser Gly Gly Glu Leu Phe Glu Arg Ile Ile
                85                  90                  95      
Asp Glu Asp Phe Glu Leu Thr Glu Arg Glu Cys Ile Lys Tyr Met Arg
            100                 105                 110         
Gln Ile Ser Glu Gly Val Glu Tyr Ile His Lys Gln Gly Ile Val His
        115                 120                 125             
Leu Asp Leu Lys Pro Glu Asn Ile Met Cys Val Asn Lys Thr Gly Thr
    130                 135                 140                 
Arg Ile Lys Leu Ile Asp Phe Gly Leu Ala Arg Arg Leu Glu Asn Ala
145                 150                 155                 160 
Gly Ser Leu Lys Val Leu Phe Gly Thr Pro Glu Phe Val Ala Pro Glu
                165                 170                 175     
Val Ile Asn Tyr Glu Pro Ile Gly Tyr Ala Thr Asp Met Trp Ser Ile
            180                 185                 190         
Gly Val Ile Cys Tyr Ile Leu Val Ser Gly Leu Ser Pro Phe Met Gly
        195                 200                 205             
Asp Asn Asp Asn Glu Thr Leu Ala Asn Val Thr Ser Ala Thr Trp Asp
    210                 215                 220                 
Phe Asp Asp Glu Ala Phe Asp Glu Ile Ser Asp Asp Ala Lys Asp Phe
225                 230                 235                 240 
Ile Ser Asn Leu Leu Lys Lys Asp Met Lys Asn Arg Leu Asp Cys Thr
                245                 250                 255     
Gln Cys Leu Gln His Pro Trp Leu Met Lys Asp Thr Lys Asn Met Glu
            260                 265                 270         
Ala Lys Lys Leu Ser Lys Asp Arg Met Lys Lys Tyr Met Ala Arg Arg
        275                 280                 285             
Lys Trp Gln Lys Thr Gly Asn Ala Val Arg Ala Ile Gly Arg Leu Ser
    290                 295                 300                 
Ser Met Ala Met Ile Ser Gly Leu Ser Gly Arg Lys Ser Ser Thr Gly
305                 310                 315                 320 
Ser Pro Thr Ser Pro Leu Asn Ala Glu Lys Leu Glu Ser Glu Asp Val
                325                 330                 335     
Ser Gln Ala Phe Leu Glu Ala Val Ala Glu Glu Lys Pro His Val Lys
            340                 345                 350         
Pro Tyr Phe Ser Lys Thr Ile Arg Asp Leu Glu Val Val Glu Gly Ser
        355                 360                 365             
Ala Ala Arg Phe Asp Cys Lys Ile Glu Gly Tyr Pro Asp Pro Glu Val
    370                 375                 380                 
Val Trp Phe Lys Asp Asp Gln Ser Ile Arg Glu Ser Arg His Phe Gln
385                 390                 395                 400 
Ile Asp Tyr Asp Glu Asp Gly Asn Cys Ser Leu Ile Ile Ser Asp Val
                405                 410                 415     
Cys Gly Asp Asp Asp Ala Lys Tyr Thr Cys Lys Ala Val Asn Ser Leu
            420                 425                 430         
Gly Glu Ala Thr Cys Thr Ala Glu Leu Ile Val Glu Thr Met Glu Glu
        435                 440                 445             
Gly Glu Gly Glu Gly Glu Glu Glu Glu Glu
    450                 455             


<210> 164
<211> 193
<212> PRT
<213> Homo sapiens

<400> 164
Gln Phe Arg Asp Val Ala Ile Glu Phe Ser Leu Glu Glu Trp His Cys
 1               5                  10                  15      
Leu Asp Thr Ala Gln Arg Asn Leu Tyr Arg Asn Val Met Leu Glu Asn
            20                  25                  30          
Tyr Ser Asn Leu Val Phe Leu Gly Ile Val Val Ser Lys Pro Asp Leu
        35                  40                  45              
Ile Ala His Leu Glu Gln Gly Lys Lys Pro Leu Thr Met Lys Arg His
    50                  55                  60                  
Glu Met Val Ala Asn Pro Ser Gly Pro Val Ile Cys Ser His Phe Ala
65                  70                  75                  80  
Gln Asp Leu Trp Pro Glu His Asn Ile Lys Asp Ser Phe Gln Lys Val
                85                  90                  95      
Ile Leu Arg Arg Tyr Glu Lys Arg Gly His Gly Asn Leu Gln Leu Ile
            100                 105                 110         
Lys Arg Cys Glu Arg Val Asp Glu Cys Lys Val His Thr Gly Gly Tyr
        115                 120                 125             
Asn Gly Leu Asn Gln Ser Ser Thr Thr Thr Gln Ser Lys Val Phe Gln
    130                 135                 140                 
Cys Asp Lys Tyr Gly Lys Asp Phe His Lys Phe Ser Asn Ser Asn Arg
145                 150                 155                 160 
His Asn Ile Arg His Thr Glu Lys Lys Pro Phe Lys Cys Ile Glu Cys
                165                 170                 175     
Gly Lys Ala Phe Asn Gln Phe Ser Thr Leu Ile Thr His Lys Lys Ile
            180                 185                 190         
His
    


<210> 165
<211> 567
<212> PRT
<213> Homo sapiens

<400> 165
Thr Arg Val Asn Ser Glu Gln Glu His Phe Leu Ile Val Pro Phe Gly
 1               5                  10                  15      
Leu Leu Tyr Ser Glu Val Thr Ala Ser Ser Leu Val Lys Ile Asn Leu
            20                  25                  30          
Gln Gly Asp Ile Val Asp Arg Gly Ser Thr Asn Leu Gly Val Asn Gln
        35                  40                  45              
Ala Gly Phe Thr Leu His Ser Ala Ile Tyr Ala Ala Arg Pro Asp Val
    50                  55                  60                  
Lys Cys Val Val His Ile His Thr Pro Ala Gly Ala Ala Val Ser Ala
65                  70                  75                  80  
Met Lys Cys Gly Leu Leu Pro Ile Ser Pro Glu Ala Leu Ser Leu Gly
                85                  90                  95      
Glu Val Ala Tyr His Asp Tyr His Gly Ile Leu Val Asp Glu Glu Glu
            100                 105                 110         
Lys Val Leu Ile Gln Lys Asn Leu Gly Pro Lys Ser Lys Val Leu Ile
        115                 120                 125             
Leu Arg Asn His Gly Leu Val Ser Val Gly Glu Ser Val Glu Glu Ala
    130                 135                 140                 
Phe Tyr Tyr Ile His Asn Leu Val Val Ala Cys Glu Ile Gln Val Arg
145                 150                 155                 160 
Thr Leu Ala Ser Ala Gly Gly Pro Asp Asn Leu Val Leu Leu Asn Pro
                165                 170                 175     
Glu Lys Tyr Lys Ala Lys Ser Arg Ser Pro Gly Ser Pro Val Gly Glu
            180                 185                 190         
Gly Thr Gly Ser Pro Pro Lys Trp Gln Ile Gly Glu Gln Glu Phe Glu
        195                 200                 205             
Ala Leu Met Arg Met Leu Asp Asn Leu Gly Tyr Arg Thr Gly Tyr Pro
    210                 215                 220                 
Tyr Arg Tyr Pro Ala Leu Arg Glu Lys Ser Lys Lys Tyr Ser Asp Val
225                 230                 235                 240 
Glu Val Pro Ala Ser Val Thr Gly Tyr Ser Phe Ala Ser Asp Gly Asp
                245                 250                 255     
Ser Gly Thr Cys Ser Pro Leu Arg His Ser Phe Gln Lys Gln Gln Arg
            260                 265                 270         
Glu Lys Thr Arg Trp Leu Asn Ser Gly Arg Gly Asp Glu Ala Ser Glu
        275                 280                 285             
Glu Gly Gln Asn Gly Ser Ser Pro Lys Ser Lys Thr Lys Trp Thr Lys
    290                 295                 300                 
Glu Asp Gly His Arg Thr Ser Thr Ser Ala Val Pro Asn Leu Phe Val
305                 310                 315                 320 
Pro Leu Asn Thr Asn Pro Lys Glu Val Gln Glu Met Arg Asn Lys Ile
                325                 330                 335     
Arg Glu Gln Asn Leu Gln Asp Ile Lys Thr Ala Gly Pro Gln Ser Gln
            340                 345                 350         
Val Leu Cys Gly Val Val Met Asp Arg Ser Leu Val Gln Gly Glu Leu
        355                 360                 365             
Val Thr Ala Ser Lys Ala Ile Ile Glu Lys Glu Tyr Gln Pro His Val
    370                 375                 380                 
Ile Val Ser Thr Thr Gly Pro Asn Pro Phe Thr Thr Leu Thr Asp Arg
385                 390                 395                 400 
Glu Leu Glu Glu Tyr Arg Arg Glu Val Glu Arg Lys Gln Lys Gly Ser
                405                 410                 415     
Glu Glu Asn Leu Asp Glu Ala Arg Glu Gln Lys Glu Lys Ser Pro Pro
            420                 425                 430         
Asp Gln Pro Ala Val Pro His Pro Pro Pro Ser Thr Pro Ile Lys Leu
        435                 440                 445             
Glu Glu Asp Leu Val Pro Glu Pro Thr Thr Gly Asp Asp Ser Asp Ala
    450                 455                 460                 
Ala Thr Phe Lys Pro Thr Leu Pro Asp Leu Ser Pro Asp Glu Pro Ser
465                 470                 475                 480 
Glu Ala Leu Gly Phe Pro Met Leu Glu Lys Glu Glu Glu Ala His Arg
                485                 490                 495     
Pro Pro Ser Pro Thr Glu Ala Pro Thr Glu Ala Ser Pro Glu Pro Ala
            500                 505                 510         
Pro Asp Pro Ala Pro Val Ala Glu Glu Ala Ala Pro Ser Ala Val Glu
        515                 520                 525             
Glu Gly Ala Ala Ala Asp Pro Gly Ser Asp Gly Ser Pro Gly Lys Ser
    530                 535                 540                 
Pro Ser Lys Lys Lys Lys Lys Phe Arg Thr Pro Ser Phe Leu Lys Lys
545                 550                 555                 560 
Ser Lys Lys Lys Ser Asp Ser
                565         


<210> 166
<211> 1225
<212> PRT
<213> Homo sapiens

<400> 166
Ile Glu Asn Phe Lys Ser Tyr Lys Gly Arg Gln Ile Ile Gly Pro Phe
 1               5                  10                  15      
Gln Arg Phe Thr Ala Ile Ile Gly Pro Asn Gly Ser Gly Lys Ser Asn
            20                  25                  30          
Leu Met Asp Ala Ile Ser Phe Val Leu Gly Glu Lys Thr Ser Asn Leu
        35                  40                  45              
Arg Val Lys Thr Leu Arg Asp Leu Ile His Gly Ala Pro Val Gly Lys
    50                  55                  60                  
Pro Ala Ala Asn Arg Ala Phe Val Ser Met Val Tyr Ser Glu Glu Gly
65                  70                  75                  80  
Ala Glu Asp Arg Thr Phe Ala Arg Val Ile Val Gly Gly Ser Ser Glu
                85                  90                  95      
Tyr Lys Ile Asn Asn Lys Val Val Gln Leu His Glu Tyr Ser Glu Glu
            100                 105                 110         
Leu Glu Lys Leu Gly Ile Leu Ile Lys Ala Arg Asn Phe Leu Val Phe
        115                 120                 125             
Gln Gly Ala Val Glu Ser Ile Ala Met Lys Asn Pro Lys Glu Arg Thr
    130                 135                 140                 
Ala Leu Phe Glu Glu Ile Ser Arg Ser Gly Glu Leu Ala Gln Glu Tyr
145                 150                 155                 160 
Asp Lys Arg Lys Lys Glu Met Val Lys Ala Glu Glu Asp Thr Gln Phe
                165                 170                 175     
Asn Tyr His Arg Lys Lys Asn Ile Ala Ala Glu Arg Lys Glu Ala Lys
            180                 185                 190         
Gln Glu Lys Glu Glu Ala Asp Arg Tyr Gln Arg Leu Lys Asp Glu Val
        195                 200                 205             
Val Arg Ala Gln Val Gln Leu Gln Leu Phe Lys Leu Tyr His Asn Glu
    210                 215                 220                 
Val Glu Ile Glu Lys Leu Asn Lys Glu Leu Ala Ser Lys Asn Lys Glu
225                 230                 235                 240 
Ile Glu Lys Asp Lys Lys Arg Met Asp Lys Val Glu Asp Glu Leu Lys
                245                 250                 255     
Glu Lys Lys Lys Glu Leu Gly Lys Met Met Arg Glu Gln Gln Gln Ile
            260                 265                 270         
Glu Lys Glu Ile Lys Glu Lys Asp Ser Glu Leu Asn Gln Lys Arg Pro
        275                 280                 285             
Gln Tyr Ile Lys Ala Lys Glu Asn Thr Ser His Lys Ile Lys Lys Leu
    290                 295                 300                 
Glu Ala Ala Lys Lys Ser Leu Gln Asn Ala Gln Lys His Tyr Lys Lys
305                 310                 315                 320 
Arg Lys Gly Asp Met Asp Glu Leu Glu Lys Glu Met Leu Ser Val Glu
                325                 330                 335     
Lys Ala Arg Gln Glu Phe Glu Glu Arg Met Glu Glu Glu Ser Gln Ser
            340                 345                 350         
Gln Gly Arg Asp Leu Thr Leu Glu Glu Asn Gln Val Lys Lys Tyr His
        355                 360                 365             
Arg Leu Lys Glu Glu Ala Ser Lys Arg Ala Ala Thr Leu Ala Gln Glu
    370                 375                 380                 
Leu Glu Lys Phe Asn Arg Asp Gln Lys Ala Asp Gln Asp Arg Leu Asp
385                 390                 395                 400 
Leu Glu Glu Arg Lys Lys Val Glu Thr Glu Ala Lys Ile Lys Gln Lys
                405                 410                 415     
Leu Arg Glu Ile Glu Glu Asn Gln Lys Arg Ile Glu Lys Leu Glu Glu
            420                 425                 430         
Tyr Ile Thr Thr Ser Lys Gln Ser Leu Glu Glu Gln Lys Lys Leu Glu
        435                 440                 445             
Gly Glu Leu Thr Glu Glu Val Glu Met Ala Lys Arg Arg Ile Asp Glu
    450                 455                 460                 
Ile Asn Lys Glu Leu Asn Gln Val Met Glu Gln Leu Gly Asp Ala Arg
465                 470                 475                 480 
Ile Asp Arg Gln Glu Ser Ser Arg Gln Gln Arg Lys Ala Glu Ile Met
                485                 490                 495     
Glu Ser Ile Lys Arg Leu Tyr Pro Gly Ser Val Tyr Gly Arg Leu Ile
            500                 505                 510         
Asp Leu Cys Gln Pro Thr Gln Lys Lys Tyr Gln Ile Ala Val Thr Lys
        515                 520                 525             
Val Leu Gly Lys Asn Met Asp Ala Ile Ile Val Asp Ser Glu Lys Thr
    530                 535                 540                 
Gly Arg Asp Cys Ile Gln Tyr Ile Lys Glu Gln Arg Gly Glu Pro Glu
545                 550                 555                 560 
Thr Phe Leu Pro Leu Asp Tyr Leu Glu Val Lys Pro Thr Asp Glu Lys
                565                 570                 575     
Leu Arg Glu Leu Lys Gly Ala Lys Leu Val Ile Asp Val Ile Arg Tyr
            580                 585                 590         
Glu Pro Pro His Ile Lys Lys Ala Leu Gln Tyr Ala Cys Gly Asn Ala
        595                 600                 605             
Leu Val Cys Asp Asn Val Glu Asp Ala Arg Arg Ile Ala Phe Gly Gly
    610                 615                 620                 
His Gln Arg His Lys Thr Val Ala Leu Asp Gly Thr Leu Phe Gln Lys
625                 630                 635                 640 
Ser Gly Val Ile Ser Gly Gly Ala Ser Asp Leu Lys Ala Lys Ala Arg
                645                 650                 655     
Arg Trp Asp Glu Lys Ala Val Asp Lys Leu Lys Glu Lys Lys Glu Arg
            660                 665                 670         
Leu Thr Glu Glu Leu Lys Glu Gln Met Lys Ala Lys Arg Lys Glu Ala
        675                 680                 685             
Glu Leu Arg Gln Val Gln Ser Gln Ala His Gly Leu Gln Met Arg Leu
    690                 695                 700                 
Lys Tyr Ser Gln Ser Asp Leu Glu Gln Thr Lys Thr Arg His Leu Ala
705                 710                 715                 720 
Leu Asn Leu Gln Glu Lys Ser Lys Leu Glu Ser Glu Leu Ala Asn Phe
                725                 730                 735     
Gly Pro Arg Ile Asn Asp Ile Lys Arg Ile Ile Gln Ser Arg Glu Arg
            740                 745                 750         
Glu Met Lys Asp Leu Lys Glu Lys Met Asn Gln Val Glu Asp Glu Val
        755                 760                 765             
Phe Glu Glu Phe Cys Arg Glu Ile Gly Val Arg Asn Ile Arg Glu Phe
    770                 775                 780                 
Glu Glu Glu Lys Val Lys Arg Gln Asn Glu Ile Ala Lys Lys Arg Leu
785                 790                 795                 800 
Glu Phe Glu Asn Gln Lys Thr Arg Leu Gly Ile Gln Leu Asp Phe Glu
                805                 810                 815     
Lys Asn Gln Leu Lys Glu Asp Gln Asp Lys Val His Met Trp Glu Gln
            820                 825                 830         
Thr Val Lys Lys Asp Glu Asn Glu Ile Glu Lys Leu Lys Lys Glu Glu
        835                 840                 845             
Gln Arg His Met Lys Ile Ile Asp Glu Thr Met Ala Gln Leu Gln Asp
    850                 855                 860                 
Leu Lys Asn Gln His Leu Ala Lys Lys Ser Glu Val Asn Asp Lys Asn
865                 870                 875                 880 
His Glu Met Glu Glu Ile Arg Lys Lys Leu Gly Gly Ala Asn Lys Glu
                885                 890                 895     
Met Thr His Leu Gln Lys Glu Val Thr Ala Ile Glu Thr Lys Leu Glu
            900                 905                 910         
Gln Lys Arg Ser Asp Arg His Asn Leu Leu Gln Ala Cys Lys Met Gln
        915                 920                 925             
Asp Ile Lys Leu Pro Leu Ser Lys Gly Thr Met Asp Asp Ile Ser Gln
    930                 935                 940                 
Glu Glu Gly Ser Ser Gln Gly Glu Asp Ser Val Ser Gly Ser Gln Arg
945                 950                 955                 960 
Ile Ser Ser Ile Tyr Ala Arg Glu Ala Leu Ile Glu Ile Asp Tyr Gly
                965                 970                 975     
Asp Leu Cys Glu Asp Leu Lys Asp Ala Gln Ala Glu Glu Glu Ile Lys
            980                 985                 990         
Gln Glu Met Asn Thr Leu Gln Gln Lys Leu Asn Glu Gln Gln Ser Val
        995                 1000                1005            
Leu Gln Arg Ile Ala Ala Pro Asn Met Lys Ala Met Glu Lys Leu Glu
    1010                1015                1020                
Ser Val Arg Asp Lys Phe Gln Glu Thr Ser Asp Glu Phe Glu Ala Ala
1025                1030                1035                1040
Arg Lys Arg Ala Lys Lys Ala Lys Gln Ala Phe Glu Gln Ile Lys Lys
                1045                1050                1055    
Glu Arg Phe Asp Arg Phe Asn Ala Cys Phe Glu Ser Val Ala Thr Asn
            1060                1065                1070        
Ile Asp Glu Ile Tyr Lys Ala Leu Ser Arg Asn Ser Ser Ala Gln Ala
        1075                1080                1085            
Phe Leu Gly Pro Glu Asn Pro Glu Glu Pro Tyr Leu Asp Gly Ile Asn
    1090                1095                1100                
Tyr Asn Cys Val Ala Pro Gly Lys Arg Phe Arg Pro Met Asp Asn Leu
1105                1110                1115                1120
Ser Gly Gly Glu Lys Thr Val Ala Ala Leu Ala Leu Leu Phe Ala Ile
                1125                1130                1135    
His Ser Tyr Lys Pro Ala Pro Phe Phe Val Leu Asp Glu Ile Asp Ala
            1140                1145                1150        
Ala Leu Asp Asn Thr Asn Ile Gly Lys Val Ala Asn Tyr Ile Lys Glu
        1155                1160                1165            
Gln Ser Thr Cys Asn Phe Gln Ala Ile Val Ile Ser Leu Lys Glu Glu
    1170                1175                1180                
Phe Tyr Thr Lys Ala Glu Ser Leu Ile Gly Val Tyr Pro Glu Gln Gly
1185                1190                1195                1200
Asp Cys Val Ile Ser Lys Val Leu Thr Phe Asp Leu Thr Lys Tyr Pro
                1205                1210                1215    
Asp Ala Asn Pro Asn Pro Asn Glu Gln
            1220                1225


<210> 167
<211> 539
<212> PRT
<213> Homo sapiens

<400> 167
Met Ala Leu His Val Pro Lys Ala Pro Gly Phe Ala Gln Met Leu Lys
 1               5                  10                  15      
Glu Gly Ala Lys His Phe Ser Gly Leu Glu Glu Ala Val Tyr Arg Asn
            20                  25                  30          
Ile Gln Ala Cys Lys Glu Leu Ala Gln Thr Thr Arg Thr Ala Tyr Gly
        35                  40                  45              
Pro Lys Gly Met Asn Lys Met Val Ile Asn His Leu Glu Lys Leu Phe
    50                  55                  60                  
Val Thr Asn Asp Ala Ala Thr Ile Leu Arg Glu Leu Glu Val Gln His
65                  70                  75                  80  
Pro Ala Ala Lys Met Ile Val Met Ala Ser His Met Gln Glu Gln Glu
                85                  90                  95      
Val Gly Asp Gly Thr Asn Phe Val Leu Val Phe Ala Gly Ala Leu Leu
            100                 105                 110         
Glu Leu Ala Glu Glu Leu Leu Arg Ile Gly Leu Ser Val Ser Glu Val
        115                 120                 125             
Ile Glu Gly Tyr Glu Ile Ala Cys Arg Lys Ala His Glu Ile Leu Pro
    130                 135                 140                 
Asn Leu Val Cys Cys Ser Ala Lys Asn Leu Arg Asp Ile Asp Glu Val
145                 150                 155                 160 
Ser Ser Leu Leu Arg Thr Ser Ile Met Ser Lys Gln Tyr Gly Asn Glu
                165                 170                 175     
Val Phe Leu Ala Lys Leu Ile Ala Gln Ala Cys Val Ser Ile Phe Pro
            180                 185                 190         
Asp Ser Gly His Phe Asn Val Asp Asn Ile Arg Val Cys Lys Ile Leu
        195                 200                 205             
Gly Ser Gly Ile Ser Ser Ser Ser Val Leu His Gly Met Val Phe Lys
    210                 215                 220                 
Lys Glu Thr Glu Gly Asp Val Thr Ser Val Lys Asp Ala Lys Ile Ala
225                 230                 235                 240 
Val Tyr Ser Cys Pro Phe Asp Gly Met Ile Thr Glu Thr Lys Gly Thr
                245                 250                 255     
Val Leu Ile Lys Thr Ala Glu Glu Leu Met Asn Phe Ser Lys Gly Glu
            260                 265                 270         
Glu Asn Leu Met Asp Ala Gln Val Lys Ala Ile Ala Asp Thr Gly Ala
        275                 280                 285             
Asn Val Val Val Thr Gly Gly Lys Val Ala Asp Met Ala Leu His Tyr
    290                 295                 300                 
Ala Asn Lys Tyr Asn Ile Met Leu Val Arg Leu Asn Ser Lys Trp Asp
305                 310                 315                 320 
Leu Arg Arg Leu Cys Lys Thr Val Gly Ala Thr Ala Leu Pro Arg Leu
                325                 330                 335     
Thr Pro Pro Val Leu Glu Glu Met Gly His Cys Asp Ser Val Tyr Leu
            340                 345                 350         
Ser Glu Val Gly Asp Thr Gln Val Val Val Phe Lys His Glu Lys Glu
        355                 360                 365             
Asp Gly Ala Ile Ser Thr Ile Val Leu Arg Gly Ser Thr Asp Asn Leu
    370                 375                 380                 
Met Asp Asp Ile Glu Arg Ala Val Asp Asp Gly Val Asn Thr Phe Lys
385                 390                 395                 400 
Val Leu Thr Arg Asp Lys Arg Leu Val Pro Gly Gly Gly Ala Thr Glu
                405                 410                 415     
Ile Glu Leu Ala Lys Gln Ile Thr Ser Tyr Gly Glu Thr Cys Pro Gly
            420                 425                 430         
Leu Glu Gln Tyr Ala Ile Lys Lys Phe Ala Glu Ala Phe Glu Ala Ile
        435                 440                 445             
Pro Arg Ala Leu Ala Glu Asn Ser Gly Val Lys Ala Asn Glu Val Ile
    450                 455                 460                 
Ser Lys Leu Tyr Ala Val His Gln Glu Gly Asn Lys Asn Val Gly Leu
465                 470                 475                 480 
Asp Ile Glu Ala Glu Val Pro Ala Val Lys Asp Met Leu Glu Ala Gly
                485                 490                 495     
Ile Leu Asp Thr Tyr Leu Gly Lys Tyr Trp Ala Ile Lys Leu Ala Thr
            500                 505                 510         
Asn Ala Ala Val Thr Val Leu Arg Val Asp Gln Ile Ile Met Ala Lys
        515                 520                 525             
Pro Ala Gly Gly Pro Lys Pro Pro Ser Gly Lys
    530                 535                 


<210> 168
<211> 564
<212> PRT
<213> Homo sapiens

<400> 168
Arg Thr Ser Asn Met Val Gly Leu Ser Tyr Pro Pro Ala Val Ile Glu
 1               5                  10                  15      
Ala Leu Lys Asp Val Asp Lys Trp Ser Phe Asp Val Phe Ser Leu Asn
            20                  25                  30          
Glu Ala Ser Gly Asp His Ala Leu Lys Phe Ile Phe Tyr Glu Leu Leu
        35                  40                  45              
Thr Arg Tyr Asp Leu Ile Ser Arg Phe Lys Ile Pro Ile Ser Ala Leu
    50                  55                  60                  
Val Ser Phe Val Glu Ala Leu Glu Val Gly Tyr Ser Lys His Lys Asn
65                  70                  75                  80  
Pro Tyr His Asn Leu Met His Ala Ala Asp Val Thr Gln Thr Val His
                85                  90                  95      
Tyr Leu Leu Tyr Lys Thr Gly Val Ala Asn Trp Leu Thr Glu Leu Glu
            100                 105                 110         
Ile Phe Ala Ile Ile Phe Ser Ala Ala Ile His Asp Tyr Glu His Thr
        115                 120                 125             
Gly Thr Thr Asn Asn Phe His Ile Gln Thr Arg Ser Asp Pro Ala Ile
    130                 135                 140                 
Leu Tyr Asn Asp Arg Ser Val Leu Glu Asn His His Leu Ser Ala Ala
145                 150                 155                 160 
Tyr Arg Leu Leu Gln Asp Asp Glu Glu Met Asn Ile Leu Ile Asn Leu
                165                 170                 175     
Ser Lys Asp Asp Trp Arg Glu Phe Arg Thr Leu Val Ile Glu Met Val
            180                 185                 190         
Met Ala Thr Asp Met Ser Cys His Phe Gln Gln Ile Lys Ala Met Lys
        195                 200                 205             
Thr Ala Leu Gln Gln Pro Glu Ala Ile Glu Lys Pro Lys Ala Leu Ser
    210                 215                 220                 
Leu Met Leu His Thr Ala Asp Ile Ser His Pro Ala Lys Ala Trp Asp
225                 230                 235                 240 
Leu His His Arg Trp Thr Met Ser Leu Leu Glu Glu Phe Phe Arg Gln
                245                 250                 255     
Gly Asp Arg Glu Ala Glu Leu Gly Leu Pro Phe Ser Pro Leu Cys Asp
            260                 265                 270         
Arg Lys Ser Thr Met Val Ala Gln Ser Gln Val Gly Phe Ile Asp Phe
        275                 280                 285             
Ile Val Glu Pro Thr Phe Thr Val Leu Thr Asp Met Thr Glu Lys Ile
    290                 295                 300                 
Val Ser Pro Leu Ile Asp Glu Thr Ser Gln Thr Gly Gly Thr Gly Gln
305                 310                 315                 320 
Arg Arg Ser Ser Leu Asn Ser Ile Ser Ser Ser Asp Ala Lys Arg Ser
                325                 330                 335     
Gly Val Lys Thr Ser Gly Ser Glu Gly Ser Ala Pro Ile Asn Asn Ser
            340                 345                 350         
Val Ile Ser Val Asp Tyr Lys Ser Phe Lys Ala Thr Trp Thr Glu Val
        355                 360                 365             
Val His Ile Asn Arg Glu Arg Trp Arg Ala Lys Val Pro Lys Glu Glu
    370                 375                 380                 
Lys Ala Lys Lys Glu Ala Glu Glu Lys Ala Arg Leu Ala Ala Glu Glu
385                 390                 395                 400 
Gln Gln Lys Glu Met Glu Ala Lys Ser Gln Ala Glu Glu Gly Ala Ser
                405                 410                 415     
Gly Lys Ala Glu Lys Lys Thr Ser Gly Glu Thr Lys Asn Gln Val Asn
            420                 425                 430         
Gly Thr Arg Ala Asn Lys Ser Asp Asn Pro Arg Gly Lys Asn Ser Lys
        435                 440                 445             
Ala Glu Lys Ser Ser Gly Glu Gln Gln Gln Asn Gly Asp Phe Lys Asp
    450                 455                 460                 
Gly Lys Asn Lys Thr Asp Lys Lys Asp His Ser Asn Ile Gly Asn Asp
465                 470                 475                 480 
Ser Lys Lys Thr Asp Gly Thr Lys Gln Arg Ser His Gly Ser Pro Ala
                485                 490                 495     
Pro Ser Thr Ser Ser Thr Cys Arg Leu Thr Leu Pro Val Ile Lys Pro
            500                 505                 510         
Pro Leu Arg His Phe Lys Arg Pro Ala Tyr Ala Ser Ser Ser Tyr Ala
        515                 520                 525             
Pro Ser Val Ser Lys Lys Thr Asp Glu His Pro Ala Arg Tyr Lys Met
    530                 535                 540                 
Leu Asp Gln Arg Ile Lys Met Lys Lys Ile Gln Asn Ile Ser His Asn
545                 550                 555                 560 
Trp Asn Arg Lys
                


<210> 169
<211> 279
<212> PRT
<213> Homo sapiens

<400> 169
Met Thr Glu Arg Phe Asp Cys His His Cys Asn Glu Ser Leu Phe Gly
 1               5                  10                  15      
Lys Lys Tyr Ile Leu Arg Glu Glu Ser Pro Tyr Cys Val Val Cys Phe
            20                  25                  30          
Glu Thr Leu Phe Ala Asn Thr Cys Glu Glu Cys Gly Lys Pro Ile Gly
        35                  40                  45              
Cys Asp Cys Lys Asp Leu Ser Tyr Lys Asp Arg His Trp His Glu Ala
    50                  55                  60                  
Cys Phe His Cys Ser Gln Cys Arg Asn Ser Leu Val Asp Lys Pro Phe
65                  70                  75                  80  
Ala Ala Lys Glu Asp Gln Leu Leu Cys Thr Asp Cys Tyr Ser Asn Glu
                85                  90                  95      
Tyr Ser Ser Lys Cys Gln Glu Cys Lys Lys Thr Ile Met Pro Gly Thr
            100                 105                 110         
Arg Lys Met Glu Tyr Lys Gly Ser Ser Trp His Glu Thr Cys Phe Ile
        115                 120                 125             
Cys His Arg Cys Gln Gln Pro Ile Gly Thr Lys Ser Phe Ile Pro Lys
    130                 135                 140                 
Asp Asn Gln Asn Phe Cys Val Pro Cys Tyr Glu Lys Gln His Ala Met
145                 150                 155                 160 
Gln Cys Val Gln Cys Lys Lys Pro Ile Thr Thr Gly Gly Val Thr Tyr
                165                 170                 175     
Arg Glu Gln Pro Trp His Lys Glu Cys Phe Val Cys Thr Ala Cys Arg
            180                 185                 190         
Lys Gln Leu Ser Gly Gln Arg Phe Thr Ala Arg Asp Asp Phe Ala Tyr
        195                 200                 205             
Cys Leu Asn Cys Phe Cys Asp Leu Tyr Ala Lys Lys Cys Ala Gly Cys
    210                 215                 220                 
Thr Asn Pro Ile Ser Gly Leu Gly Gly Thr Lys Tyr Ile Ser Phe Glu
225                 230                 235                 240 
Glu Arg Gln Trp His Asn Asp Cys Phe Asn Cys Lys Lys Cys Ser Leu
                245                 250                 255     
Ser Leu Val Gly Arg Gly Phe Leu Thr Glu Arg Asp Asp Ile Leu Cys
            260                 265                 270         
Pro Asp Cys Gly Lys Asp Ile
        275                 


<210> 170
<211> 291
<212> PRT
<213> Homo sapiens

<400> 170
Met Ala Val Gln Val Val Gln Ala Val Gln Ala Val His Leu Glu Ser
 1               5                  10                  15      
Asp Ala Phe Leu Val Cys Leu Asn His Ala Leu Ser Thr Glu Lys Glu
            20                  25                  30          
Glu Val Met Gly Leu Cys Ile Gly Glu Leu Asn Asp Asp Thr Arg Ser
        35                  40                  45              
Asp Ser Lys Phe Ala Tyr Thr Gly Thr Glu Met Arg Thr Val Ala Glu
    50                  55                  60                  
Lys Val Asp Ala Val Arg Ile Val His Ile His Ser Val Ile Ile Leu
65                  70                  75                  80  
Arg Arg Ser Asp Lys Arg Lys Asp Arg Val Glu Ile Ser Pro Glu Gln
                85                  90                  95      
Leu Ser Ala Ala Ser Thr Glu Ala Glu Arg Leu Ala Glu Leu Thr Gly
            100                 105                 110         
Arg Pro Met Arg Val Val Gly Trp Tyr His Ser His Pro His Ile Thr
        115                 120                 125             
Val Trp Pro Ser His Val Asp Val Arg Thr Gln Ala Met Tyr Gln Met
    130                 135                 140                 
Met Asp Gln Gly Phe Val Gly Leu Ile Phe Ser Cys Phe Ile Glu Asp
145                 150                 155                 160 
Lys Asn Thr Lys Thr Gly Arg Val Leu Tyr Thr Cys Phe Gln Ser Ile
                165                 170                 175     
Gln Ala Gln Lys Ser Ser Glu Tyr Glu Arg Ile Glu Ile Pro Ile His
            180                 185                 190         
Ile Val Pro His Val Thr Ile Gly Lys Val Cys Leu Glu Ser Ala Val
        195                 200                 205             
Glu Leu Pro Lys Ile Leu Cys Gln Glu Glu Gln Asp Ala Tyr Arg Arg
    210                 215                 220                 
Ile His Ser Leu Thr His Leu Asp Ser Val Thr Lys Ile His Asn Gly
225                 230                 235                 240 
Ser Val Phe Thr Lys Asn Leu Cys Ser Gln Met Ser Ala Val Ser Gly
                245                 250                 255     
Pro Leu Leu Gln Trp Leu Glu Asp Arg Leu Glu Gln Asn Gln Gln His
            260                 265                 270         
Leu Gln Glu Leu Gln Gln Glu Lys Glu Glu Leu Met Gln Glu Leu Ser
        275                 280                 285             
Ser Leu Glu
    290     


<210> 171
<211> 1078
<212> PRT
<213> Homo sapiens

<400> 171
Met Ala Phe Tyr Ser Cys Cys Trp Val Leu Leu Ala Leu Thr Trp His
 1               5                  10                  15      
Thr Ser Ala Tyr Gly Pro Asp Gln Arg Ala Gln Lys Lys Gly Asp Ile
            20                  25                  30          
Ile Leu Gly Gly Leu Phe Pro Ile His Phe Gly Val Ala Ala Lys Asp
        35                  40                  45              
Gln Asp Leu Lys Ser Arg Pro Glu Ser Val Glu Cys Ile Arg Tyr Asn
    50                  55                  60                  
Phe Arg Gly Phe Arg Trp Leu Gln Ala Met Ile Phe Ala Ile Glu Glu
65                  70                  75                  80  
Ile Asn Ser Ser Pro Ala Leu Leu Pro Asn Leu Thr Leu Gly Tyr Arg
                85                  90                  95      
Ile Phe Asp Thr Cys Asn Thr Val Ser Lys Ala Leu Glu Ala Thr Leu
            100                 105                 110         
Ser Phe Val Ala Gln Asn Lys Ile Asp Ser Leu Asn Leu Asp Glu Phe
        115                 120                 125             
Cys Asn Cys Ser Glu His Ile Pro Ser Thr Ile Ala Val Val Gly Ala
    130                 135                 140                 
Thr Gly Ser Gly Val Ser Thr Ala Val Ala Asn Leu Leu Gly Leu Phe
145                 150                 155                 160 
Tyr Ile Pro Gln Val Ser Tyr Ala Ser Ser Ser Arg Leu Leu Ser Asn
                165                 170                 175     
Lys Asn Gln Phe Lys Ser Phe Leu Arg Thr Ile Pro Asn Asp Glu His
            180                 185                 190         
Gln Ala Thr Ala Met Ala Asp Ile Ile Glu Tyr Phe Arg Trp Asn Trp
        195                 200                 205             
Val Gly Thr Ile Ala Ala Asp Asp Asp Tyr Gly Arg Pro Gly Ile Glu
    210                 215                 220                 
Lys Phe Arg Glu Glu Ala Glu Glu Arg Asp Ile Cys Ile Asp Phe Ser
225                 230                 235                 240 
Glu Leu Ile Ser Gln Tyr Ser Asp Glu Glu Glu Ile Gln His Val Val
                245                 250                 255     
Glu Val Ile Gln Asn Ser Thr Ala Lys Val Ile Val Val Phe Ser Ser
            260                 265                 270         
Gly Pro Asp Leu Glu Pro Leu Ile Lys Glu Ile Val Arg Arg Asn Ile
        275                 280                 285             
Thr Gly Lys Ile Trp Leu Ala Ser Glu Ala Trp Ala Ser Ser Ser Leu
    290                 295                 300                 
Ile Ala Met Pro Gln Tyr Phe His Val Val Gly Gly Thr Ile Gly Phe
305                 310                 315                 320 
Ala Leu Lys Ala Gly Gln Ile Pro Gly Phe Arg Glu Phe Leu Lys Lys
                325                 330                 335     
Val His Pro Arg Lys Ser Val His Asn Gly Phe Ala Lys Glu Phe Trp
            340                 345                 350         
Glu Glu Thr Phe Asn Cys His Leu Gln Glu Gly Ala Lys Gly Pro Leu
        355                 360                 365             
Pro Val Asp Thr Phe Leu Arg Gly His Glu Glu Ser Gly Asp Arg Phe
    370                 375                 380                 
Ser Asn Ser Ser Thr Ala Phe Arg Pro Leu Cys Thr Gly Asp Glu Asn
385                 390                 395                 400 
Ile Ser Ser Val Glu Thr Pro Tyr Ile Asp Tyr Thr His Leu Arg Ile
                405                 410                 415     
Ser Tyr Asn Val Tyr Leu Ala Val Tyr Ser Ile Ala His Ala Leu Gln
            420                 425                 430         
Asp Ile Tyr Thr Cys Leu Pro Gly Arg Gly Leu Phe Thr Asn Gly Ser
        435                 440                 445             
Cys Ala Asp Ile Lys Lys Val Glu Ala Trp Gln Val Leu Lys His Leu
    450                 455                 460                 
Arg His Leu Asn Phe Thr Asn Asn Met Gly Glu Gln Val Thr Phe Asp
465                 470                 475                 480 
Glu Cys Gly Asp Leu Val Gly Asn Tyr Ser Ile Ile Asn Trp His Leu
                485                 490                 495     
Ser Pro Glu Asp Gly Ser Ile Val Phe Lys Glu Val Gly Tyr Tyr Asn
            500                 505                 510         
Val Tyr Ala Lys Lys Gly Glu Arg Leu Phe Ile Asn Glu Glu Lys Ile
        515                 520                 525             
Leu Trp Ser Gly Phe Ser Arg Glu Val Pro Phe Ser Asn Cys Ser Arg
    530                 535                 540                 
Asp Cys Leu Ala Gly Thr Arg Lys Gly Ile Ile Glu Gly Glu Pro Thr
545                 550                 555                 560 
Cys Cys Phe Glu Cys Val Glu Cys Pro Asp Gly Glu Tyr Ser Asp Glu
                565                 570                 575     
Thr Asp Ala Ser Ala Cys Asn Lys Cys Pro Asp Asp Phe Trp Ser Asn
            580                 585                 590         
Glu Asn His Thr Ser Cys Ile Ala Lys Glu Ile Glu Phe Leu Ser Trp
        595                 600                 605             
Thr Glu Pro Phe Gly Ile Ala Leu Thr Leu Phe Ala Val Leu Gly Ile
    610                 615                 620                 
Phe Leu Thr Ala Phe Val Leu Gly Val Phe Ile Lys Phe Arg Asn Thr
625                 630                 635                 640 
Pro Ile Val Lys Ala Thr Asn Arg Glu Leu Ser Tyr Leu Leu Leu Phe
                645                 650                 655     
Ser Leu Leu Cys Cys Phe Ser Ser Ser Leu Phe Phe Ile Gly Glu Pro
            660                 665                 670         
Gln Asp Trp Thr Cys Arg Leu Arg Gln Pro Ala Phe Gly Ile Ser Phe
        675                 680                 685             
Val Leu Cys Ile Ser Cys Ile Leu Val Lys Thr Asn Arg Val Leu Leu
    690                 695                 700                 
Val Phe Glu Ala Lys Ile Pro Thr Ser Phe His Arg Lys Trp Trp Gly
705                 710                 715                 720 
Leu Asn Leu Gln Phe Leu Leu Val Phe Leu Cys Thr Phe Met Gln Ile
                725                 730                 735     
Val Ile Cys Val Ile Trp Leu Tyr Thr Ala Pro Pro Ser Ser Tyr Arg
            740                 745                 750         
Asn Gln Glu Leu Glu Asp Glu Ile Ile Phe Ile Thr Cys His Glu Gly
        755                 760                 765             
Ser Leu Met Ala Leu Gly Phe Leu Ile Gly Tyr Thr Cys Leu Leu Ala
    770                 775                 780                 
Ala Ile Cys Phe Phe Phe Ala Phe Lys Ser Arg Lys Leu Pro Glu Asn
785                 790                 795                 800 
Phe Asn Glu Ala Lys Phe Ile Thr Phe Ser Met Leu Ile Phe Phe Ile
                805                 810                 815     
Val Trp Ile Ser Phe Ile Pro Ala Tyr Ala Ser Thr Tyr Gly Lys Phe
            820                 825                 830         
Val Ser Ala Val Glu Val Ile Ala Ile Leu Ala Ala Ser Phe Gly Leu
        835                 840                 845             
Leu Ala Cys Ile Phe Phe Asn Lys Ile Tyr Ile Ile Leu Phe Lys Pro
    850                 855                 860                 
Ser Arg Asn Thr Ile Glu Glu Val Arg Cys Ser Thr Ala Ala His Ala
865                 870                 875                 880 
Phe Lys Val Ala Ala Arg Ala Thr Leu Arg Arg Ser Asn Val Ser Arg
                885                 890                 895     
Lys Arg Ser Ser Ser Leu Gly Gly Ser Thr Gly Ser Thr Pro Ser Ser
            900                 905                 910         
Ser Ile Ser Ser Lys Ser Asn Ser Glu Asp Pro Phe Pro Gln Pro Glu
        915                 920                 925             
Arg Gln Lys Gln Gln Gln Pro Leu Ala Leu Thr Gln Gln Glu Gln Gln
    930                 935                 940                 
Gln Gln Pro Leu Thr Leu Pro Gln Gln Gln Arg Ser Gln Gln Gln Pro
945                 950                 955                 960 
Arg Cys Lys Gln Lys Val Ile Phe Gly Ser Gly Thr Val Thr Phe Ser
                965                 970                 975     
Leu Ser Phe Asp Glu Pro Gln Lys Asn Ala Met Ala His Arg Asn Ser
            980                 985                 990         
Thr His Gln Asn Ser Leu Glu Ala Gln Lys Ser Ser Asp Thr Leu Thr
        995                 1000                1005            
Arg His Gln Pro Leu Leu Pro Leu Gln Cys Gly Glu Thr Asp Leu Asp
    1010                1015                1020                
Leu Thr Val Gln Glu Thr Gly Leu Gln Gly Pro Val Gly Gly Asp Gln
1025                1030                1035                1040
Arg Pro Glu Val Glu Asp Pro Glu Glu Leu Ser Pro Ala Leu Val Val
                1045                1050                1055    
Ser Ser Ser Gln Ser Phe Val Ile Ser Gly Gly Gly Ser Thr Val Thr
            1060                1065                1070        
Glu Asn Val Val Asn Ser
        1075            


<210> 172
<211> 277
<212> PRT
<213> Homo sapiens

<400> 172
Met Glu Asn Thr Glu Asn Ser Val Asp Ser Lys Ser Ile Lys Asn Leu
 1               5                  10                  15      
Glu Pro Lys Ile Ile His Gly Ser Glu Ser Met Asp Ser Gly Ile Ser
            20                  25                  30          
Leu Asp Asn Ser Tyr Lys Met Asp Tyr Pro Glu Met Gly Leu Cys Ile
        35                  40                  45              
Ile Ile Asn Asn Lys Asn Phe His Lys Ser Thr Gly Met Thr Ser Arg
    50                  55                  60                  
Ser Gly Thr Asp Val Asp Ala Ala Asn Leu Arg Glu Thr Phe Arg Asn
65                  70                  75                  80  
Leu Lys Tyr Glu Val Arg Asn Lys Asn Asp Leu Thr Arg Glu Glu Ile
                85                  90                  95      
Val Glu Leu Met Arg Asp Val Ser Lys Glu Asp His Ser Lys Arg Ser
            100                 105                 110         
Ser Phe Val Cys Val Leu Leu Ser His Gly Glu Glu Gly Ile Ile Phe
        115                 120                 125             
Gly Thr Asn Gly Pro Val Asp Leu Lys Lys Ile Thr Asn Phe Phe Arg
    130                 135                 140                 
Gly Asp Arg Cys Arg Ser Leu Thr Gly Lys Pro Lys Leu Phe Ile Ile
145                 150                 155                 160 
Gln Ala Cys Arg Gly Thr Glu Leu Asp Cys Gly Ile Glu Thr Asp Ser
                165                 170                 175     
Gly Val Asp Asp Asp Met Ala Cys His Lys Ile Pro Val Asp Ala Asp
            180                 185                 190         
Phe Leu Tyr Ala Tyr Ser Thr Ala Pro Gly Tyr Tyr Ser Trp Arg Asn
        195                 200                 205             
Ser Lys Asp Gly Ser Trp Phe Ile Gln Ser Leu Cys Ala Met Leu Lys
    210                 215                 220                 
Gln Tyr Ala Asp Lys Leu Glu Phe Met His Ile Leu Thr Arg Val Asn
225                 230                 235                 240 
Arg Lys Val Ala Thr Glu Phe Glu Ser Phe Ser Phe Asp Ala Thr Phe
                245                 250                 255     
His Ala Lys Lys Gln Ile Pro Cys Ile Val Ser Met Leu Thr Lys Glu
            260                 265                 270         
Leu Tyr Phe Tyr His
        275         


<210> 173
<211> 302
<212> PRT
<213> Homo sapiens

<400> 173
Met Ala Leu Val Ala Ser Val Arg Val Pro Ala Arg Val Leu Leu Arg
 1               5                  10                  15      
Ala Gly Ala Arg Leu Pro Gly Ala Ala Leu Gly Arg Thr Glu Arg Ala
            20                  25                  30          
Ala Gly Gly Gly Asp Gly Ala Arg Arg Phe Gly Ser Gln Arg Val Leu
        35                  40                  45              
Val Glu Pro Asp Ala Gly Ala Gly Val Ala Val Met Lys Phe Lys Asn
    50                  55                  60                  
Pro Pro Val Asn Ser Leu Ser Leu Glu Phe Leu Thr Glu Leu Val Ile
65                  70                  75                  80  
Ser Leu Glu Lys Leu Glu Asn Asp Lys Ser Phe Arg Gly Val Ile Leu
                85                  90                  95      
Thr Ser Asp Arg Pro Gly Val Phe Ser Ala Gly Leu Asp Leu Thr Glu
            100                 105                 110         
Met Cys Gly Arg Ser Pro Ala His Tyr Ala Gly Tyr Trp Lys Ala Val
        115                 120                 125             
Gln Glu Leu Trp Leu Arg Leu Tyr Gln Ser Asn Leu Val Leu Val Ser
    130                 135                 140                 
Ala Ile Asn Gly Ala Cys Pro Ala Gly Gly Cys Leu Val Ala Leu Thr
145                 150                 155                 160 
Cys Asp Tyr Arg Ile Leu Ala Asp Asn Pro Arg Tyr Cys Ile Gly Leu
                165                 170                 175     
Asn Glu Thr Gln Leu Gly Ile Ile Ala Pro Phe Trp Leu Lys Asp Thr
            180                 185                 190         
Leu Glu Asn Thr Ile Gly His Arg Ala Ala Glu Arg Ala Leu Gln Leu
        195                 200                 205             
Gly Leu Leu Phe Pro Pro Ala Glu Ala Leu Gln Val Gly Ile Val Asp
    210                 215                 220                 
Gln Val Val Pro Glu Glu Gln Val Gln Ser Thr Ala Leu Ser Ala Ile
225                 230                 235                 240 
Ala Gln Trp Met Ala Ile Pro Asp His Ala Arg Gln Leu Thr Lys Ala
                245                 250                 255     
Met Met Arg Lys Ala Thr Ala Ser Arg Leu Val Thr Gln Arg Asp Ala
            260                 265                 270         
Asp Val Gln Asn Phe Val Ser Phe Ile Ser Lys Asp Ser Ile Gln Lys
        275                 280                 285             
Ser Leu Gln Met Tyr Leu Glu Arg Leu Lys Glu Glu Lys Gly
    290                 295                 300         


<210> 174
<211> 3256
<212> PRT
<213> Homo sapiens

<400> 174
Met Trp Pro Thr Arg Arg Leu Val Thr Ile Lys Arg Ser Gly Val Asp
 1               5                  10                  15      
Gly Pro His Phe Pro Leu Ser Leu Ser Thr Cys Leu Phe Gly Arg Gly
            20                  25                  30          
Ile Glu Cys Asp Ile Arg Ile Gln Leu Pro Val Val Ser Lys Gln His
        35                  40                  45              
Cys Lys Ile Glu Ile His Glu Gln Glu Ala Ile Leu His Asn Phe Ser
    50                  55                  60                  
Ser Thr Asn Pro Thr Gln Val Asn Gly Ser Val Ile Asp Glu Pro Val
65                  70                  75                  80  
Arg Leu Lys His Gly Asp Val Ile Thr Ile Ile Asp Arg Ser Phe Arg
                85                  90                  95      
Tyr Glu Asn Glu Ser Leu Gln Asn Gly Arg Lys Ser Thr Glu Phe Pro
            100                 105                 110         
Arg Lys Ile Arg Glu Gln Glu Pro Ala Arg Arg Val Ser Arg Ser Ser
        115                 120                 125             
Phe Ser Ser Asp Pro Asp Glu Lys Ala Gln Asp Ser Lys Ala Tyr Ser
    130                 135                 140                 
Lys Ile Thr Glu Gly Lys Val Ser Gly Asn Pro Gln Val His Ile Lys
145                 150                 155                 160 
Asn Val Lys Glu Asp Ser Thr Ala Asp Asp Ser Lys Asp Ser Val Ala
                165                 170                 175     
Gln Gly Thr Thr Asn Val His Ser Ser Glu His Ala Gly Arg Asn Gly
            180                 185                 190         
Arg Asn Ala Ala Asp Pro Ile Ser Gly Asp Phe Lys Glu Ile Ser Ser
        195                 200                 205             
Val Lys Leu Val Ser Arg Tyr Gly Glu Leu Lys Ser Val Pro Thr Thr
    210                 215                 220                 
Gln Cys Leu Asp Asn Ser Lys Lys Asn Glu Ser Pro Phe Trp Lys Leu
225                 230                 235                 240 
Tyr Glu Ser Val Lys Lys Glu Leu Asp Val Lys Ser Gln Lys Glu Asn
                245                 250                 255     
Val Leu Gln Tyr Cys Arg Lys Ser Gly Leu Gln Thr Asp Tyr Ala Thr
            260                 265                 270         
Glu Lys Glu Ser Ala Asp Gly Leu Gln Gly Glu Thr Gln Leu Leu Val
        275                 280                 285             
Ser Arg Lys Ser Arg Pro Lys Ser Gly Gly Ser Gly His Ala Val Ala
    290                 295                 300                 
Glu Pro Ala Ser Pro Glu Gln Glu Leu Asp Gln Asn Lys Gly Lys Gly
305                 310                 315                 320 
Arg Asp Val Glu Ser Val Gln Thr Pro Ser Lys Ala Val Gly Ala Ser
                325                 330                 335     
Phe Pro Leu Tyr Glu Pro Ala Lys Met Lys Thr Pro Val Gln Tyr Ser
            340                 345                 350         
Gln Gln Gln Asn Ser Pro Gln Lys His Lys Asn Lys Asp Leu Tyr Thr
        355                 360                 365             
Thr Gly Arg Arg Glu Ser Val Asn Leu Gly Lys Ser Glu Gly Phe Lys
    370                 375                 380                 
Ala Gly Asp Lys Thr Leu Thr Pro Arg Lys Leu Ser Thr Arg Asn Arg
385                 390                 395                 400 
Thr Pro Ala Lys Val Glu Asp Ala Ala Asp Ser Ala Thr Lys Pro Glu
                405                 410                 415     
Asn Leu Ser Ser Lys Thr Arg Gly Ser Ile Pro Thr Asp Val Glu Val
            420                 425                 430         
Leu Pro Thr Glu Thr Glu Ile His Asn Glu Pro Phe Leu Thr Leu Trp
        435                 440                 445             
Leu Thr Gln Val Glu Arg Lys Ile Gln Lys Asp Ser Leu Ser Lys Pro
    450                 455                 460                 
Glu Lys Leu Gly Thr Thr Ala Gly Gln Met Cys Ser Gly Leu Pro Gly
465                 470                 475                 480 
Leu Ser Ser Val Asp Ile Asn Asn Phe Gly Asp Ser Ile Asn Glu Ser
                485                 490                 495     
Glu Gly Ile Pro Leu Lys Arg Arg Arg Val Ser Phe Gly Gly His Leu
            500                 505                 510         
Arg Pro Glu Leu Phe Asp Glu Asn Leu Pro Pro Asn Thr Pro Leu Lys
        515                 520                 525             
Arg Gly Glu Ala Pro Thr Lys Arg Lys Ser Leu Val Met His Thr Pro
    530                 535                 540                 
Pro Val Leu Lys Lys Ile Ile Lys Glu Gln Pro Gln Pro Ser Gly Lys
545                 550                 555                 560 
Gln Glu Ser Gly Ser Glu Ile His Val Glu Val Lys Ala Gln Ser Leu
                565                 570                 575     
Val Ile Ser Pro Pro Ala Pro Ser Pro Arg Lys Thr Pro Val Ala Ser
            580                 585                 590         
Asp Gln Arg Arg Arg Ser Cys Lys Thr Ala Pro Ala Ser Ser Ser Lys
        595                 600                 605             
Ser Gln Thr Glu Val Pro Lys Arg Gly Gly Glu Arg Val Ala Thr Cys
    610                 615                 620                 
Leu Gln Lys Arg Val Ser Ile Ser Arg Ser Gln His Asp Ile Leu Gln
625                 630                 635                 640 
Met Ile Cys Ser Lys Arg Arg Ser Gly Ala Ser Glu Ala Asn Leu Ile
                645                 650                 655     
Val Ala Lys Ser Trp Ala Asp Val Val Lys Leu Gly Ala Lys Gln Thr
            660                 665                 670         
Gln Thr Lys Val Ile Lys His Gly Pro Gln Arg Ser Met Asn Lys Arg
        675                 680                 685             
Gln Arg Arg Pro Ala Thr Pro Lys Lys Pro Val Gly Glu Val His Ser
    690                 695                 700                 
Gln Phe Ser Thr Gly His Ala Asn Ser Pro Cys Thr Ile Ile Ile Gly
705                 710                 715                 720 
Lys Ala His Thr Glu Lys Val His Val Pro Ala Arg Pro Tyr Arg Val
                725                 730                 735     
Leu Asn Asn Phe Ile Ser Asn Gln Lys Met Asp Phe Lys Glu Asp Leu
            740                 745                 750         
Ser Gly Ile Ala Glu Met Phe Lys Thr Pro Val Lys Glu Gln Pro Gln
        755                 760                 765             
Leu Thr Ser Thr Cys His Ile Ala Ile Ser Asn Ser Glu Asn Leu Leu
    770                 775                 780                 
Gly Lys Gln Phe Gln Gly Thr Asp Ser Gly Glu Glu Pro Leu Leu Pro
785                 790                 795                 800 
Thr Ser Glu Ser Phe Gly Gly Asn Val Phe Phe Ser Ala Gln Asn Ala
                805                 810                 815     
Ala Lys Gln Pro Ser Asp Lys Cys Ser Ala Ser Pro Pro Leu Arg Arg
            820                 825                 830         
Gln Cys Ile Arg Glu Asn Gly Asn Val Ala Lys Thr Pro Arg Asn Thr
        835                 840                 845             
Tyr Lys Met Thr Ser Leu Glu Thr Lys Thr Ser Asp Thr Glu Thr Glu
    850                 855                 860                 
Pro Ser Lys Thr Val Ser Thr Val Asn Arg Ser Gly Arg Ser Thr Glu
865                 870                 875                 880 
Phe Arg Asn Ile Gln Lys Leu Pro Val Glu Ser Lys Ser Glu Glu Thr
                885                 890                 895     
Asn Thr Glu Ile Val Glu Cys Ile Leu Lys Arg Gly Gln Lys Ala Thr
            900                 905                 910         
Leu Leu Gln Gln Arg Arg Glu Gly Glu Met Lys Glu Ile Glu Arg Pro
        915                 920                 925             
Phe Glu Thr Tyr Lys Glu Asn Ile Glu Leu Lys Glu Asn Asp Glu Lys
    930                 935                 940                 
Met Lys Ala Met Lys Arg Ser Arg Thr Trp Gly Gln Lys Cys Ala Pro
945                 950                 955                 960 
Met Ser Asp Leu Thr Asp Leu Lys Ser Leu Pro Asp Thr Glu Leu Met
                965                 970                 975     
Lys Asp Thr Ala Arg Gly Gln Asn Leu Leu Gln Thr Gln Asp His Ala
            980                 985                 990         
Lys Ala Pro Lys Ser Glu Lys Gly Lys Ile Thr Lys Met Pro Cys Gln
        995                 1000                1005            
Ser Leu Gln Pro Glu Pro Ile Asn Thr Pro Thr His Thr Lys Gln Gln
    1010                1015                1020                
Leu Lys Ala Ser Leu Gly Lys Val Gly Val Lys Glu Glu Leu Leu Ala
1025                1030                1035                1040
Val Gly Lys Phe Thr Arg Thr Ser Gly Glu Thr Thr His Thr His Arg
                1045                1050                1055    
Glu Pro Ala Gly Asp Gly Lys Ser Ile Arg Thr Phe Lys Glu Ser Pro
            1060                1065                1070        
Lys Gln Ile Leu Asp Pro Ala Ala Arg Val Thr Gly Met Lys Lys Trp
        1075                1080                1085            
Pro Arg Thr Pro Lys Glu Glu Ala Gln Ser Leu Glu Asp Leu Ala Gly
    1090                1095                1100                
Phe Lys Glu Leu Phe Gln Thr Pro Gly Pro Ser Glu Glu Ser Met Thr
1105                1110                1115                1120
Asp Glu Lys Thr Thr Lys Ile Ala Cys Lys Ser Pro Pro Pro Glu Ser
                1125                1130                1135    
Val Asp Thr Pro Thr Ser Thr Lys Gln Trp Pro Lys Arg Ser Leu Arg
            1140                1145                1150        
Lys Ala Asp Val Glu Glu Glu Phe Leu Ala Leu Arg Lys Leu Thr Pro
        1155                1160                1165            
Ser Ala Gly Lys Ala Met Leu Thr Pro Lys Pro Ala Gly Gly Asp Glu
    1170                1175                1180                
Lys Asp Ile Lys Ala Phe Met Gly Thr Pro Val Gln Lys Leu Asp Leu
1185                1190                1195                1200
Ala Gly Thr Leu Pro Gly Ser Lys Arg Gln Leu Gln Thr Pro Lys Glu
                1205                1210                1215    
Lys Ala Gln Ala Leu Glu Asp Leu Ala Gly Phe Lys Glu Leu Phe Gln
            1220                1225                1230        
Thr Pro Gly His Thr Glu Glu Leu Val Ala Ala Gly Lys Thr Thr Lys
        1235                1240                1245            
Ile Pro Cys Asp Ser Pro Gln Ser Asp Pro Val Asp Thr Pro Thr Ser
    1250                1255                1260                
Thr Lys Gln Arg Pro Lys Arg Ser Ile Arg Lys Ala Asp Val Glu Gly
1265                1270                1275                1280
Glu Leu Leu Ala Cys Arg Asn Leu Met Pro Ser Ala Gly Lys Ala Met
                1285                1290                1295    
His Thr Pro Lys Pro Ser Val Gly Glu Glu Lys Asp Ile Ile Ile Phe
            1300                1305                1310        
Val Gly Thr Pro Val Gln Lys Leu Asp Leu Thr Glu Asn Leu Thr Gly
        1315                1320                1325            
Ser Lys Arg Arg Pro Gln Thr Pro Lys Glu Glu Ala Gln Ala Leu Glu
    1330                1335                1340                
Asp Leu Thr Gly Phe Lys Glu Leu Phe Gln Thr Pro Gly His Thr Glu
1345                1350                1355                1360
Glu Ala Val Ala Ala Gly Lys Thr Thr Lys Met Pro Cys Glu Ser Ser
                1365                1370                1375    
Pro Pro Glu Ser Ala Asp Thr Pro Thr Ser Thr Arg Arg Gln Pro Lys
            1380                1385                1390        
Thr Pro Leu Glu Lys Arg Asp Val Gln Lys Glu Leu Ser Ala Leu Lys
        1395                1400                1405            
Lys Leu Thr Gln Thr Ser Gly Glu Thr Thr His Thr Asp Lys Val Pro
    1410                1415                1420                
Gly Gly Glu Asp Lys Ser Ile Asn Ala Phe Arg Glu Thr Ala Lys Gln
1425                1430                1435                1440
Lys Leu Asp Pro Ala Ala Ser Val Thr Gly Ser Lys Arg His Pro Lys
                1445                1450                1455    
Thr Lys Glu Lys Ala Gln Pro Leu Glu Asp Leu Ala Gly Trp Lys Glu
            1460                1465                1470        
Leu Phe Gln Thr Pro Val Cys Thr Asp Lys Pro Thr Thr His Glu Lys
        1475                1480                1485            
Thr Thr Lys Ile Ala Cys Arg Ser Gln Pro Asp Pro Val Asp Thr Pro
    1490                1495                1500                
Thr Ser Ser Lys Pro Gln Ser Lys Arg Ser Leu Arg Lys Val Asp Val
1505                1510                1515                1520
Glu Glu Glu Phe Phe Ala Leu Arg Lys Arg Thr Pro Ser Ala Gly Lys
                1525                1530                1535    
Ala Met His Thr Pro Lys Pro Ala Val Ser Gly Glu Lys Asn Ile Tyr
            1540                1545                1550        
Ala Phe Met Gly Thr Pro Val Gln Lys Leu Asp Leu Thr Glu Asn Leu
        1555                1560                1565            
Thr Gly Ser Lys Arg Arg Leu Gln Thr Pro Lys Glu Lys Ala Gln Ala
    1570                1575                1580                
Leu Glu Asp Leu Ala Gly Phe Lys Glu Leu Phe Gln Thr Arg Gly His
1585                1590                1595                1600
Thr Glu Glu Ser Met Thr Asn Asp Lys Thr Ala Lys Val Ala Cys Lys
                1605                1610                1615    
Ser Ser Gln Pro Asp Leu Asp Lys Asn Pro Ala Ser Ser Lys Arg Arg
            1620                1625                1630        
Leu Lys Thr Ser Leu Gly Lys Val Gly Val Lys Glu Glu Leu Leu Ala
        1635                1640                1645            
Val Gly Lys Leu Thr Gln Thr Ser Gly Glu Thr Thr His Thr His Thr
    1650                1655                1660                
Glu Pro Thr Gly Asp Gly Lys Ser Met Lys Ala Phe Met Glu Ser Pro
1665                1670                1675                1680
Lys Gln Ile Leu Asp Ser Ala Ala Ser Leu Thr Gly Ser Lys Arg Gln
                1685                1690                1695    
Leu Arg Thr Pro Lys Gly Lys Ser Glu Val Pro Glu Asp Leu Ala Gly
            1700                1705                1710        
Phe Ile Glu Leu Phe Gln Thr Pro Ser His Thr Lys Glu Ser Met Thr
        1715                1720                1725            
Asn Glu Lys Thr Thr Lys Val Ser Tyr Arg Ala Ser Gln Pro Asp Leu
    1730                1735                1740                
Val Asp Thr Pro Thr Ser Ser Lys Pro Gln Pro Lys Arg Ser Leu Arg
1745                1750                1755                1760
Lys Ala Asp Thr Glu Glu Glu Phe Leu Ala Phe Arg Lys Gln Thr Pro
                1765                1770                1775    
Ser Ala Gly Lys Ala Met His Thr Pro Lys Pro Ala Val Gly Glu Glu
            1780                1785                1790        
Lys Asp Ile Asn Thr Phe Leu Gly Thr Pro Val Gln Lys Leu Asp Gln
        1795                1800                1805            
Pro Gly Asn Leu Pro Gly Ser Asn Arg Arg Leu Gln Thr Arg Lys Glu
    1810                1815                1820                
Lys Ala Gln Ala Leu Glu Glu Leu Thr Gly Phe Arg Glu Leu Phe Gln
1825                1830                1835                1840
Thr Pro Cys Thr Asp Asn Pro Thr Ala Asp Glu Lys Thr Thr Lys Lys
                1845                1850                1855    
Ile Leu Cys Lys Ser Pro Gln Ser Asp Pro Ala Asp Thr Pro Thr Asn
            1860                1865                1870        
Thr Lys Gln Arg Pro Lys Arg Ser Leu Lys Lys Ala Asp Val Glu Glu
        1875                1880                1885            
Glu Phe Leu Ala Phe Arg Lys Leu Thr Pro Ser Ala Gly Lys Ala Met
    1890                1895                1900                
His Thr Pro Lys Ala Ala Val Gly Glu Glu Lys Asp Ile Asn Thr Phe
1905                1910                1915                1920
Val Gly Thr Pro Val Glu Lys Leu Asp Leu Leu Gly Asn Leu Pro Gly
                1925                1930                1935    
Ser Lys Arg Arg Pro Gln Thr Pro Lys Glu Lys Ala Lys Ala Leu Glu
            1940                1945                1950        
Asp Leu Ala Gly Phe Lys Glu Leu Phe Gln Thr Pro Gly His Thr Glu
        1955                1960                1965            
Glu Ser Met Thr Asp Asp Lys Ile Thr Glu Val Ser Cys Lys Ser Pro
    1970                1975                1980                
Gln Pro Asp Pro Val Lys Thr Pro Thr Ser Ser Lys Gln Arg Leu Lys
1985                1990                1995                2000
Ile Ser Leu Gly Lys Val Gly Val Lys Glu Glu Val Leu Pro Val Gly
                2005                2010                2015    
Lys Leu Thr Gln Thr Ser Gly Lys Thr Thr Gln Thr His Arg Glu Thr
            2020                2025                2030        
Ala Gly Asp Gly Lys Ser Ile Lys Ala Phe Lys Glu Ser Ala Lys Gln
        2035                2040                2045            
Met Leu Asp Pro Ala Asn Tyr Gly Thr Gly Met Glu Arg Trp Pro Arg
    2050                2055                2060                
Thr Pro Lys Glu Glu Ala Gln Ser Leu Glu Asp Leu Ala Gly Phe Lys
2065                2070                2075                2080
Glu Leu Phe Gln Thr Pro Asp His Thr Glu Glu Ser Thr Thr Asp Asp
                2085                2090                2095    
Lys Thr Thr Lys Ile Ala Cys Lys Ser Pro Pro Pro Glu Ser Met Asp
            2100                2105                2110        
Thr Pro Thr Ser Thr Arg Arg Arg Pro Lys Thr Pro Leu Gly Lys Arg
        2115                2120                2125            
Asp Ile Val Glu Glu Leu Ser Ala Leu Lys Gln Leu Thr Gln Thr Thr
    2130                2135                2140                
His Thr Asp Lys Val Pro Gly Asp Glu Asp Lys Gly Ile Asn Val Phe
2145                2150                2155                2160
Arg Glu Thr Ala Lys Gln Lys Leu Asp Pro Ala Ala Ser Val Thr Gly
                2165                2170                2175    
Ser Lys Arg Gln Pro Arg Thr Pro Lys Gly Lys Ala Gln Pro Leu Glu
            2180                2185                2190        
Asp Leu Ala Gly Leu Lys Glu Leu Phe Gln Thr Pro Val Cys Thr Asp
        2195                2200                2205            
Lys Pro Thr Thr His Glu Lys Thr Thr Lys Ile Ala Cys Arg Ser Pro
    2210                2215                2220                
Gln Pro Asp Pro Val Gly Thr Pro Thr Ile Phe Lys Pro Gln Ser Lys
2225                2230                2235                2240
Arg Ser Leu Arg Lys Ala Asp Val Glu Glu Glu Ser Leu Ala Leu Arg
                2245                2250                2255    
Lys Arg Thr Pro Ser Val Gly Lys Ala Met Asp Thr Pro Lys Pro Ala
            2260                2265                2270        
Gly Gly Asp Glu Lys Asp Met Lys Ala Phe Met Gly Thr Pro Val Gln
        2275                2280                2285            
Lys Leu Asp Leu Pro Gly Asn Leu Pro Gly Ser Lys Arg Trp Pro Gln
    2290                2295                2300                
Thr Pro Lys Glu Lys Ala Gln Ala Leu Glu Asp Leu Ala Gly Phe Lys
2305                2310                2315                2320
Glu Leu Phe Gln Thr Pro Gly Thr Asp Lys Pro Thr Thr Asp Glu Lys
                2325                2330                2335    
Thr Thr Lys Ile Ala Cys Lys Ser Pro Gln Pro Asp Pro Val Asp Thr
            2340                2345                2350        
Pro Ala Ser Thr Lys Gln Arg Pro Lys Arg Asn Leu Arg Lys Ala Asp
        2355                2360                2365            
Val Glu Glu Glu Phe Leu Ala Leu Arg Lys Arg Thr Pro Ser Ala Gly
    2370                2375                2380                
Lys Ala Met Asp Thr Pro Lys Pro Ala Val Ser Asp Glu Lys Asn Ile
2385                2390                2395                2400
Asn Thr Phe Val Glu Thr Pro Val Gln Lys Leu Asp Leu Leu Gly Asn
                2405                2410                2415    
Leu Pro Gly Ser Lys Arg Gln Pro Gln Thr Pro Lys Glu Lys Ala Glu
            2420                2425                2430        
Ala Leu Glu Asp Leu Val Gly Phe Lys Glu Leu Phe Gln Thr Pro Gly
        2435                2440                2445            
His Thr Glu Glu Ser Met Thr Asp Asp Lys Ile Thr Glu Val Ser Cys
    2450                2455                2460                
Lys Ser Pro Gln Pro Glu Ser Phe Lys Thr Ser Arg Ser Ser Lys Gln
2465                2470                2475                2480
Arg Leu Lys Ile Pro Leu Val Lys Val Asp Met Lys Glu Glu Pro Leu
                2485                2490                2495    
Ala Val Ser Lys Leu Thr Arg Thr Ser Gly Glu Thr Thr Gln Thr His
            2500                2505                2510        
Thr Glu Pro Thr Gly Asp Ser Lys Ser Ile Lys Ala Phe Lys Glu Ser
        2515                2520                2525            
Pro Lys Gln Ile Leu Asp Pro Ala Ala Ser Val Thr Gly Ser Arg Arg
    2530                2535                2540                
Gln Leu Arg Thr Arg Lys Glu Lys Ala Arg Ala Leu Glu Asp Leu Val
2545                2550                2555                2560
Asp Phe Lys Glu Leu Phe Ser Ala Pro Gly His Thr Glu Glu Ser Met
                2565                2570                2575    
Thr Ile Asp Lys Asn Thr Lys Ile Pro Cys Lys Ser Pro Pro Pro Glu
            2580                2585                2590        
Leu Thr Asp Thr Ala Thr Ser Thr Lys Arg Cys Pro Lys Thr Arg Pro
        2595                2600                2605            
Arg Lys Glu Val Lys Glu Glu Leu Ser Ala Val Glu Arg Leu Thr Gln
    2610                2615                2620                
Thr Ser Gly Gln Ser Thr His Thr His Lys Glu Pro Ala Ser Gly Asp
2625                2630                2635                2640
Glu Gly Ile Lys Val Leu Lys Gln Arg Ala Lys Lys Lys Pro Asn Pro
                2645                2650                2655    
Val Glu Glu Glu Pro Ser Arg Arg Arg Pro Arg Ala Pro Lys Glu Lys
            2660                2665                2670        
Ala Gln Pro Leu Glu Asp Leu Ala Gly Phe Thr Glu Leu Ser Glu Thr
        2675                2680                2685            
Ser Gly His Thr Gln Glu Ser Leu Thr Ala Gly Lys Ala Thr Lys Ile
    2690                2695                2700                
Pro Cys Glu Ser Pro Pro Leu Glu Val Val Asp Thr Thr Ala Ser Thr
2705                2710                2715                2720
Lys Arg His Leu Arg Thr Arg Val Gln Lys Val Gln Val Lys Glu Glu
                2725                2730                2735    
Pro Ser Ala Val Lys Phe Thr Gln Thr Ser Gly Glu Thr Thr Asp Ala
            2740                2745                2750        
Asp Lys Glu Pro Ala Gly Glu Asp Lys Gly Ile Lys Ala Leu Lys Glu
        2755                2760                2765            
Ser Ala Lys Gln Thr Pro Ala Pro Ala Ala Ser Val Thr Gly Ser Arg
    2770                2775                2780                
Arg Arg Pro Arg Ala Pro Arg Glu Ser Ala Gln Ala Ile Glu Asp Leu
2785                2790                2795                2800
Ala Gly Phe Lys Asp Pro Ala Ala Gly His Thr Glu Glu Ser Met Thr
                2805                2810                2815    
Asp Asp Lys Thr Thr Lys Ile Pro Cys Lys Ser Ser Pro Glu Leu Glu
            2820                2825                2830        
Asp Thr Ala Thr Ser Ser Lys Arg Arg Pro Arg Thr Arg Ala Gln Lys
        2835                2840                2845            
Val Glu Val Lys Glu Glu Leu Leu Ala Val Gly Lys Leu Thr Gln Thr
    2850                2855                2860                
Ser Gly Glu Thr Thr His Thr Asp Lys Glu Pro Val Gly Glu Gly Lys
2865                2870                2875                2880
Gly Thr Lys Ala Phe Lys Gln Pro Ala Lys Arg Asn Val Asp Ala Glu
                2885                2890                2895    
Asp Val Ile Gly Ser Arg Arg Gln Pro Arg Ala Pro Lys Glu Lys Ala
            2900                2905                2910        
Gln Pro Leu Glu Asp Leu Ala Ser Phe Gln Glu Leu Ser Gln Thr Pro
        2915                2920                2925            
Gly His Thr Glu Glu Leu Ala Asn Gly Ala Ala Asp Ser Phe Thr Ser
    2930                2935                2940                
Ala Pro Lys Gln Thr Pro Asp Ser Gly Lys Pro Leu Lys Ile Ser Arg
2945                2950                2955                2960
Arg Val Leu Arg Ala Pro Lys Val Glu Pro Val Gly Asp Val Val Ser
                2965                2970                2975    
Thr Arg Asp Pro Val Lys Ser Gln Ser Lys Ser Asn Thr Ser Leu Pro
            2980                2985                2990        
Pro Leu Pro Phe Lys Arg Gly Gly Gly Lys Asp Gly Ser Val Thr Gly
        2995                3000                3005            
Thr Lys Arg Leu Arg Cys Met Pro Ala Pro Glu Glu Ile Val Glu Glu
    3010                3015                3020                
Leu Pro Ala Ser Lys Lys Gln Arg Val Ala Pro Arg Ala Arg Gly Lys
3025                3030                3035                3040
Ser Ser Glu Pro Val Val Ile Met Lys Arg Ser Leu Arg Thr Ser Ala
                3045                3050                3055    
Lys Arg Ile Glu Pro Ala Glu Glu Leu Asn Ser Asn Asp Met Lys Thr
            3060                3065                3070        
Asn Lys Glu Glu His Lys Leu Gln Asp Ser Val Pro Glu Asn Lys Gly
        3075                3080                3085            
Ile Ser Leu Arg Ser Arg Arg Gln Asp Lys Thr Glu Ala Glu Gln Gln
    3090                3095                3100                
Ile Thr Glu Val Phe Val Leu Ala Glu Arg Ile Glu Ile Asn Arg Asn
3105                3110                3115                3120
Glu Lys Lys Pro Met Lys Thr Ser Pro Glu Met Asp Ile Gln Asn Pro
                3125                3130                3135    
Asp Asp Gly Ala Arg Lys Pro Ile Pro Arg Asp Lys Val Thr Glu Asn
            3140                3145                3150        
Lys Arg Cys Leu Arg Ser Ala Arg Gln Asn Glu Ser Ser Gln Pro Lys
        3155                3160                3165            
Val Ala Glu Glu Ser Gly Gly Gln Lys Ser Ala Lys Val Leu Met Gln
    3170                3175                3180                
Asn Gln Lys Gly Lys Gly Glu Ala Gly Asn Ser Asp Ser Met Cys Leu
3185                3190                3195                3200
Arg Ser Arg Lys Thr Lys Ser Gln Pro Ala Ala Ser Thr Leu Glu Ser
                3205                3210                3215    
Lys Ser Val Gln Arg Val Thr Arg Ser Val Lys Arg Cys Ala Glu Asn
            3220                3225                3230        
Pro Lys Lys Ala Glu Asp Asn Val Cys Val Lys Lys Ile Thr Thr Arg
        3235                3240                3245            
Ser His Arg Asp Ser Glu Asp Ile
    3250                3255    


<210> 175
<211> 347
<212> PRT
<213> Homo sapiens

<400> 175
Met Ser Trp Cys Asn Glu Leu Arg Leu Pro Ala Leu Lys Gln His Ser
 1               5                  10                  15      
Ile Gly Arg Gly Leu Glu Ser His Ile Thr Met Cys Ile Pro Pro Ser
            20                  25                  30          
Tyr Ala Asp Leu Gly Lys Ala Ala Arg Asp Ile Phe Asn Lys Gly Phe
        35                  40                  45              
Gly Phe Gly Leu Val Lys Leu Asp Val Lys Thr Lys Ser Cys Ser Gly
    50                  55                  60                  
Val Glu Phe Ser Thr Ser Gly Ser Ser Asn Thr Asp Thr Gly Lys Val
65                  70                  75                  80  
Thr Gly Thr Leu Glu Thr Lys Tyr Lys Trp Cys Glu Tyr Gly Leu Thr
                85                  90                  95      
Phe Thr Glu Lys Trp Asn Thr Asp Asn Thr Leu Gly Thr Glu Ile Ala
            100                 105                 110         
Ile Glu Asp Gln Ile Cys Gln Gly Leu Lys Leu Thr Phe Asp Thr Thr
        115                 120                 125             
Phe Ser Pro Asn Thr Gly Lys Lys Ser Gly Lys Ile Lys Ser Ser Tyr
    130                 135                 140                 
Lys Arg Glu Cys Ile Asn Leu Gly Cys Asp Val Asp Phe Asp Phe Ala
145                 150                 155                 160 
Gly Pro Ala Ile His Gly Ser Ala Val Phe Gly Tyr Glu Gly Trp Leu
                165                 170                 175     
Ala Gly Tyr Gln Met Thr Phe Asp Ser Ala Lys Ser Lys Leu Thr Arg
            180                 185                 190         
Asn Asn Phe Ala Val Gly Tyr Arg Thr Gly Asp Phe Gln Leu His Thr
        195                 200                 205             
Asn Val Asn Asp Gly Thr Glu Phe Gly Gly Ser Ile Tyr Gln Lys Val
    210                 215                 220                 
Cys Glu Asp Leu Asp Thr Ser Val Asn Leu Ala Trp Thr Ser Gly Thr
225                 230                 235                 240 
Asn Cys Thr Arg Phe Gly Ile Ala Ala Lys Tyr Gln Leu Asp Pro Thr
                245                 250                 255     
Ala Ser Ile Ser Ala Lys Val Asn Asn Ser Ser Leu Ile Gly Val Gly
            260                 265                 270         
Tyr Thr Gln Thr Leu Arg Pro Gly Val Lys Leu Thr Leu Ser Ala Leu
        275                 280                 285             
Val Asp Gly Lys Ser Ile Asn Ala Gly Gly His Lys Val Gly Ser Pro
    290                 295                 300                 
Trp Ser Trp Arg Leu Asn Pro Ala Glu Arg Asn Leu Trp Glu Trp Ile
305                 310                 315                 320 
Ser Glu Asp Leu Ala Leu Ile Tyr Phe His Cys Asp Gln Gln Gln Ala
                325                 330                 335     
Phe Phe Pro Pro Glu Asp Asp Gln Asn Lys Gly
            340                 345         


<210> 176
<211> 369
<212> PRT
<213> Homo sapiens

<400> 176
Met Trp Pro Asn Gly Ser Ser Leu Gly Pro Cys Phe Arg Pro Thr Asn
 1               5                  10                  15      
Ile Thr Leu Glu Glu Arg Arg Leu Ile Ala Ser Pro Trp Phe Ala Ala
            20                  25                  30          
Ser Phe Cys Val Val Gly Leu Ala Ser Asn Leu Leu Ala Leu Ser Val
        35                  40                  45              
Leu Ala Gly Ala Arg Gln Gly Gly Ser His Thr Arg Ser Ser Phe Leu
    50                  55                  60                  
Thr Phe Leu Cys Gly Leu Val Leu Thr Asp Phe Leu Gly Leu Leu Val
65                  70                  75                  80  
Thr Gly Thr Ile Val Val Ser Gln His Ala Ala Leu Phe Glu Trp His
                85                  90                  95      
Ala Val Asp Pro Gly Cys Arg Leu Cys Arg Phe Met Gly Val Val Met
            100                 105                 110         
Ile Phe Phe Gly Leu Ser Pro Leu Leu Leu Gly Ala Ala Met Ala Ser
        115                 120                 125             
Glu Arg Tyr Leu Gly Ile Thr Arg Pro Phe Ser Arg Pro Ala Val Ala
    130                 135                 140                 
Ser Gln Arg Arg Ala Trp Ala Thr Val Gly Leu Val Trp Ala Ala Ala
145                 150                 155                 160 
Leu Ala Leu Gly Leu Leu Pro Leu Leu Gly Val Gly Arg Tyr Thr Val
                165                 170                 175     
Gln Tyr Pro Gly Ser Trp Cys Phe Leu Thr Leu Gly Ala Glu Ser Gly
            180                 185                 190         
Asp Val Ala Phe Gly Leu Leu Phe Ser Met Leu Gly Gly Leu Ser Val
        195                 200                 205             
Gly Leu Ser Phe Leu Leu Asn Thr Val Ser Val Ala Thr Leu Cys His
    210                 215                 220                 
Val Tyr His Gly Gln Glu Ala Ala Gln Gln Arg Pro Arg Asp Ser Glu
225                 230                 235                 240 
Val Glu Met Met Ala Gln Leu Leu Gly Ile Met Val Val Ala Ser Val
                245                 250                 255     
Cys Trp Leu Pro Leu Leu Val Phe Ile Ala Gln Thr Val Leu Arg Asn
            260                 265                 270         
Pro Pro Ala Met Ser Pro Ala Gly Gln Leu Ser Arg Thr Thr Glu Lys
        275                 280                 285             
Glu Leu Leu Ile Tyr Leu Arg Val Ala Thr Trp Asn Gln Ile Leu Asp
    290                 295                 300                 
Pro Trp Val Tyr Ile Leu Phe Arg Arg Ala Val Leu Arg Arg Leu Gln
305                 310                 315                 320 
Pro Arg Leu Ser Thr Arg Pro Arg Arg Val Ser Leu Cys Gly Pro Ala
                325                 330                 335     
Trp Ser Thr Val Ala Arg Ser Arg Leu Thr Ala Thr Ser Ala Ser Arg
            340                 345                 350         
Val Gln Ala Ile Leu Val Pro Gln Pro Pro Glu Gln Leu Gly Leu Gln
        355                 360                 365             
Ala
    


<210> 177
<211> 443
<212> PRT
<213> Homo sapiens

<400> 177
Met Ser Glu Pro Glu Ala Val Leu Thr Arg Arg Lys Ser Asn Val Ile
 1               5                  10                  15      
Arg Lys Pro Cys Ala Ala Glu Pro Ala Leu Ser Ala Gly Ser Leu Ala
            20                  25                  30          
Ala Glu Pro Ala Glu Asn Arg Lys Gly Thr Ala Val Pro Val Glu Cys
        35                  40                  45              
Pro Thr Cys His Lys Lys Phe Leu Ser Lys Tyr Tyr Leu Lys Val His
    50                  55                  60                  
Asn Arg Lys His Thr Gly Glu Lys Pro Phe Glu Cys Pro Lys Cys Gly
65                  70                  75                  80  
Lys Cys Tyr Phe Arg Lys Glu Asn Leu Leu Glu His Glu Ala Arg Asn
                85                  90                  95      
Cys Met Asn Arg Ser Glu Gln Val Phe Thr Cys Ser Val Cys Gln Glu
            100                 105                 110         
Thr Phe Arg Arg Arg Met Glu Leu Arg Val His Met Val Ser His Thr
        115                 120                 125             
Gly Glu Met Pro Tyr Lys Cys Ser Ser Cys Ser Gln Gln Phe Met Gln
    130                 135                 140                 
Lys Lys Asp Leu Gln Ser His Met Ile Lys Leu His Gly Ala Pro Lys
145                 150                 155                 160 
Pro His Ala Cys Pro Thr Cys Ala Lys Cys Phe Leu Ser Arg Thr Glu
                165                 170                 175     
Leu Gln Leu His Glu Ala Phe Lys His Arg Gly Glu Lys Leu Phe Val
            180                 185                 190         
Cys Glu Glu Cys Gly His Arg Ala Ser Ser Arg Asn Gly Leu Gln Met
        195                 200                 205             
His Ile Lys Ala Lys His Arg Asn Glu Arg Pro His Val Cys Glu Phe
    210                 215                 220                 
Cys Ser His Ala Phe Thr Gln Lys Ala Asn Leu Asn Met His Leu Arg
225                 230                 235                 240 
Thr His Thr Gly Glu Lys Pro Phe Gln Cys His Leu Cys Gly Lys Thr
                245                 250                 255     
Phe Arg Thr Gln Ala Ser Leu Asp Lys His Asn Arg Thr His Thr Gly
            260                 265                 270         
Glu Arg Pro Phe Ser Cys Glu Phe Cys Glu Gln Arg Phe Thr Glu Lys
        275                 280                 285             
Gly Pro Leu Leu Arg His Val Ala Ser Arg His Gln Glu Gly Arg Pro
    290                 295                 300                 
His Phe Cys Gln Ile Cys Gly Lys Thr Phe Lys Ala Val Glu Gln Leu
305                 310                 315                 320 
Arg Val His Val Arg Arg His Lys Gly Val Arg Lys Phe Glu Cys Thr
                325                 330                 335     
Glu Cys Gly Tyr Lys Phe Thr Arg Gln Ala His Leu Arg Arg His Met
            340                 345                 350         
Glu Ile His Asp Arg Val Glu Asn Tyr Asn Pro Arg Gln Arg Lys Leu
        355                 360                 365             
Arg Asn Leu Ile Ile Glu Asp Glu Lys Met Val Val Val Ala Leu Gln
    370                 375                 380                 
Pro Pro Ala Glu Leu Glu Val Gly Ser Ala Glu Val Ile Val Glu Ser
385                 390                 395                 400 
Leu Ala Gln Gly Gly Leu Ala Ser Gln Leu Pro Gly Gln Arg Leu Cys
                405                 410                 415     
Ala Glu Glu Ser Phe Thr Gly Pro Gly Val Leu Glu Pro Ser Leu Ile
            420                 425                 430         
Ile Thr Ala Ala Val Pro Glu Asp Cys Asp Thr
        435                 440             


<210> 178
<211> 3418
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 718, 2261
<223> Xaa = Any Amino Acid

<400> 178
Met Pro Ile Gly Ser Lys Glu Arg Pro Thr Phe Phe Glu Ile Phe Lys
 1               5                  10                  15      
Thr Arg Cys Asn Lys Ala Asp Leu Gly Pro Ile Ser Leu Asn Trp Phe
            20                  25                  30          
Glu Glu Leu Ser Ser Glu Ala Pro Pro Tyr Asn Ser Glu Pro Ala Glu
        35                  40                  45              
Glu Ser Glu His Lys Asn Asn Asn Tyr Glu Pro Asn Leu Phe Lys Thr
    50                  55                  60                  
Pro Gln Arg Lys Pro Ser Tyr Asn Gln Leu Ala Ser Thr Pro Ile Ile
65                  70                  75                  80  
Phe Lys Glu Gln Gly Leu Thr Leu Pro Leu Tyr Gln Ser Pro Val Lys
                85                  90                  95      
Glu Leu Asp Lys Phe Lys Leu Asp Leu Gly Arg Asn Val Pro Asn Ser
            100                 105                 110         
Arg His Lys Ser Leu Arg Thr Val Lys Thr Lys Met Asp Gln Ala Asp
        115                 120                 125             
Asp Val Ser Cys Pro Leu Leu Asn Ser Cys Leu Ser Glu Ser Pro Val
    130                 135                 140                 
Val Leu Gln Cys Thr His Val Thr Pro Gln Arg Asp Lys Ser Val Val
145                 150                 155                 160 
Cys Gly Ser Leu Phe His Thr Pro Lys Phe Val Lys Gly Arg Gln Thr
                165                 170                 175     
Pro Lys His Ile Ser Glu Ser Leu Gly Ala Glu Val Asp Pro Asp Met
            180                 185                 190         
Ser Trp Ser Ser Ser Leu Ala Thr Pro Pro Thr Leu Ser Ser Thr Val
        195                 200                 205             
Leu Ile Val Arg Asn Glu Glu Ala Ser Glu Thr Val Phe Pro His Asp
    210                 215                 220                 
Thr Thr Ala Asn Val Lys Ser Tyr Phe Ser Asn His Asp Glu Ser Leu
225                 230                 235                 240 
Lys Lys Asn Asp Arg Phe Ile Ala Ser Val Thr Asp Ser Glu Asn Thr
                245                 250                 255     
Asn Gln Arg Glu Ala Ala Ser His Gly Phe Gly Lys Thr Ser Gly Asn
            260                 265                 270         
Ser Phe Lys Val Asn Ser Cys Lys Asp His Ile Gly Lys Ser Met Pro
        275                 280                 285             
Asn Val Leu Glu Asp Glu Val Tyr Glu Thr Val Val Asp Thr Ser Glu
    290                 295                 300                 
Glu Asp Ser Phe Ser Leu Cys Phe Ser Lys Cys Arg Thr Lys Asn Leu
305                 310                 315                 320 
Gln Lys Val Arg Thr Ser Lys Thr Arg Lys Lys Ile Phe His Glu Ala
                325                 330                 335     
Asn Ala Asp Glu Cys Glu Lys Ser Lys Asn Gln Val Lys Glu Lys Tyr
            340                 345                 350         
Ser Phe Val Ser Glu Val Glu Pro Asn Asp Thr Asp Pro Leu Asp Ser
        355                 360                 365             
Asn Val Ala Asn Gln Lys Pro Phe Glu Ser Gly Ser Asp Lys Ile Ser
    370                 375                 380                 
Lys Glu Val Val Pro Ser Leu Ala Cys Glu Trp Ser Gln Leu Thr Leu
385                 390                 395                 400 
Ser Gly Leu Asn Gly Ala Gln Met Glu Lys Ile Pro Leu Leu His Ile
                405                 410                 415     
Ser Ser Cys Asp Gln Asn Ile Ser Glu Lys Asp Leu Leu Asp Thr Glu
            420                 425                 430         
Asn Lys Arg Lys Lys Asp Phe Leu Thr Ser Glu Asn Ser Leu Pro Arg
        435                 440                 445             
Ile Ser Ser Leu Pro Lys Ser Glu Lys Pro Leu Asn Glu Glu Thr Val
    450                 455                 460                 
Val Asn Lys Arg Asp Glu Glu Gln His Leu Glu Ser His Thr Asp Cys
465                 470                 475                 480 
Ile Leu Ala Val Lys Gln Ala Ile Ser Gly Thr Ser Pro Val Ala Ser
                485                 490                 495     
Ser Phe Gln Gly Ile Lys Lys Ser Ile Phe Arg Ile Arg Glu Ser Pro
            500                 505                 510         
Lys Glu Thr Phe Asn Ala Ser Phe Ser Gly His Met Thr Asp Pro Asn
        515                 520                 525             
Phe Lys Lys Glu Thr Glu Ala Ser Glu Ser Gly Leu Glu Ile His Thr
    530                 535                 540                 
Val Cys Ser Gln Lys Glu Asp Ser Leu Cys Pro Asn Leu Ile Asp Asn
545                 550                 555                 560 
Gly Ser Trp Pro Ala Thr Thr Thr Gln Asn Ser Val Ala Leu Lys Asn
                565                 570                 575     
Ala Gly Leu Ile Ser Thr Leu Lys Lys Lys Thr Asn Lys Phe Ile Tyr
            580                 585                 590         
Ala Ile His Asp Glu Thr Ser Tyr Lys Gly Lys Lys Ile Pro Lys Asp
        595                 600                 605             
Gln Lys Ser Glu Leu Ile Asn Cys Ser Ala Gln Phe Glu Ala Asn Ala
    610                 615                 620                 
Phe Glu Ala Pro Leu Thr Phe Ala Asn Ala Asp Ser Gly Leu Leu His
625                 630                 635                 640 
Ser Ser Val Lys Arg Ser Cys Ser Gln Asn Asp Ser Glu Glu Pro Thr
                645                 650                 655     
Leu Ser Leu Thr Ser Ser Phe Gly Thr Ile Leu Arg Lys Cys Ser Arg
            660                 665                 670         
Asn Glu Thr Cys Ser Asn Asn Thr Val Ile Ser Gln Asp Leu Asp Tyr
        675                 680                 685             
Lys Glu Ala Lys Cys Asn Lys Glu Lys Leu Gln Leu Phe Ile Thr Pro
    690                 695                 700                 
Glu Ala Asp Ser Leu Ser Cys Leu Gln Glu Gly Gln Cys Xaa Asn Asp
705                 710                 715                 720 
Pro Lys Ser Lys Lys Val Ser Asp Ile Lys Glu Glu Val Leu Ala Ala
                725                 730                 735     
Ala Cys His Pro Val Gln His Ser Lys Val Glu Tyr Ser Asp Thr Asp
            740                 745                 750         
Phe Gln Ser Gln Lys Asn Leu Leu Tyr Asp His Glu Asn Ala Ser Thr
        755                 760                 765             
Leu Ile Leu Thr Pro Thr Ser Lys Asp Val Leu Ser Asn Leu Val Met
    770                 775                 780                 
Ile Ser Arg Gly Lys Glu Ser Tyr Lys Met Ser Asp Lys Leu Lys Gly
785                 790                 795                 800 
Asn Asn Tyr Glu Ser Asp Val Glu Leu Thr Lys Asn Ile Pro Met Glu
                805                 810                 815     
Lys Asn Gln Asp Val Cys Ala Leu Asn Glu Asn Tyr Lys Asn Val Glu
            820                 825                 830         
Leu Leu Pro Pro Glu Lys Tyr Met Arg Val Ala Ser Pro Ser Arg Lys
        835                 840                 845             
Val Gln Phe Asn Gln Asn Thr Asn Leu Arg Val Ile Gln Lys Asn Gln
    850                 855                 860                 
Glu Glu Thr Thr Ser Ile Ser Lys Ile Thr Val Asn Pro Asp Ser Glu
865                 870                 875                 880 
Glu Leu Phe Ser Asp Asn Glu Asn Asn Phe Val Phe Gln Val Ala Asn
                885                 890                 895     
Glu Arg Asn Asn Leu Ala Leu Gly Asn Thr Lys Glu Leu His Glu Thr
            900                 905                 910         
Asp Leu Thr Cys Val Asn Glu Pro Ile Phe Lys Asn Ser Thr Met Val
        915                 920                 925             
Leu Tyr Gly Asp Thr Gly Asp Lys Gln Ala Thr Gln Val Ser Ile Lys
    930                 935                 940                 
Lys Asp Leu Val Tyr Val Leu Ala Glu Glu Asn Lys Asn Ser Val Lys
945                 950                 955                 960 
Gln His Ile Lys Met Thr Leu Gly Gln Asp Leu Lys Ser Asp Ile Ser
                965                 970                 975     
Leu Asn Ile Asp Lys Ile Pro Glu Lys Asn Asn Asp Tyr Met Asn Lys
            980                 985                 990         
Trp Ala Gly Leu Leu Gly Pro Ile Ser Asn His Ser Phe Gly Gly Ser
        995                 1000                1005            
Phe Arg Thr Ala Ser Asn Lys Glu Ile Lys Leu Ser Glu His Asn Ile
    1010                1015                1020                
Lys Lys Ser Lys Met Phe Phe Lys Asp Ile Glu Glu Gln Tyr Pro Thr
1025                1030                1035                1040
Ser Leu Ala Cys Val Glu Ile Val Asn Thr Leu Ala Leu Asp Asn Gln
                1045                1050                1055    
Lys Lys Leu Ser Lys Pro Gln Ser Ile Asn Thr Val Ser Ala His Leu
            1060                1065                1070        
Gln Ser Ser Val Val Val Ser Asp Cys Lys Asn Ser His Ile Thr Pro
        1075                1080                1085            
Gln Met Leu Phe Ser Lys Gln Asp Phe Asn Ser Asn His Asn Leu Thr
    1090                1095                1100                
Pro Ser Gln Lys Ala Glu Ile Thr Glu Leu Ser Thr Ile Leu Glu Glu
1105                1110                1115                1120
Ser Gly Ser Gln Phe Glu Phe Thr Gln Phe Arg Lys Pro Ser Tyr Ile
                1125                1130                1135    
Leu Gln Lys Ser Thr Phe Glu Val Pro Glu Asn Gln Met Thr Ile Leu
            1140                1145                1150        
Lys Thr Thr Ser Glu Glu Cys Arg Asp Ala Asp Leu His Val Ile Met
        1155                1160                1165            
Asn Ala Pro Ser Ile Gly Gln Val Asp Ser Ser Lys Gln Phe Glu Gly
    1170                1175                1180                
Thr Val Glu Ile Lys Arg Lys Phe Ala Gly Leu Leu Lys Asn Asp Cys
1185                1190                1195                1200
Asn Lys Ser Ala Ser Gly Tyr Leu Thr Asp Glu Asn Glu Val Gly Phe
                1205                1210                1215    
Arg Gly Phe Tyr Ser Ala His Gly Thr Lys Leu Asn Val Ser Thr Glu
            1220                1225                1230        
Ala Leu Gln Lys Ala Val Lys Leu Phe Ser Asp Ile Glu Asn Ile Ser
        1235                1240                1245            
Glu Glu Thr Ser Ala Glu Val His Pro Ile Ser Leu Ser Ser Ser Lys
    1250                1255                1260                
Cys His Asp Ser Val Val Ser Met Phe Lys Ile Glu Asn His Asn Asp
1265                1270                1275                1280
Lys Thr Val Ser Glu Lys Asn Asn Lys Cys Gln Leu Ile Leu Gln Asn
                1285                1290                1295    
Asn Ile Glu Met Thr Thr Gly Thr Phe Val Glu Glu Ile Thr Glu Asn
            1300                1305                1310        
Tyr Lys Arg Asn Thr Glu Asn Glu Asp Asn Lys Tyr Thr Ala Ala Ser
        1315                1320                1325            
Arg Asn Ser His Asn Leu Glu Phe Asp Gly Ser Asp Ser Ser Lys Asn
    1330                1335                1340                
Asp Thr Val Cys Ile His Lys Asp Glu Thr Asp Leu Leu Phe Thr Asp
1345                1350                1355                1360
Gln His Asn Ile Cys Leu Lys Leu Ser Gly Gln Phe Met Lys Glu Gly
                1365                1370                1375    
Asn Thr Gln Ile Lys Glu Asp Leu Ser Asp Leu Thr Phe Leu Glu Val
            1380                1385                1390        
Ala Lys Ala Gln Glu Ala Cys His Gly Asn Thr Ser Asn Lys Glu Gln
        1395                1400                1405            
Leu Thr Ala Thr Lys Thr Glu Gln Asn Ile Lys Asp Phe Glu Thr Ser
    1410                1415                1420                
Asp Thr Phe Phe Gln Thr Ala Ser Gly Lys Asn Ile Ser Val Ala Lys
1425                1430                1435                1440
Glu Ser Phe Asn Lys Ile Val Asn Phe Phe Asp Gln Lys Pro Glu Glu
                1445                1450                1455    
Leu His Asn Phe Ser Leu Asn Ser Glu Leu His Ser Asp Ile Arg Lys
            1460                1465                1470        
Asn Lys Met Asp Ile Leu Ser Tyr Glu Glu Thr Asp Ile Val Lys His
        1475                1480                1485            
Lys Ile Leu Lys Glu Ser Val Pro Val Gly Thr Gly Asn Gln Leu Val
    1490                1495                1500                
Thr Phe Gln Gly Gln Pro Glu Arg Asp Glu Lys Ile Lys Glu Pro Thr
1505                1510                1515                1520
Leu Leu Gly Phe His Thr Ala Ser Gly Lys Lys Val Lys Ile Ala Lys
                1525                1530                1535    
Glu Ser Leu Asp Lys Val Lys Asn Leu Phe Asp Glu Lys Glu Gln Gly
            1540                1545                1550        
Thr Ser Glu Ile Thr Ser Phe Ser His Gln Trp Ala Lys Thr Leu Lys
        1555                1560                1565            
Tyr Arg Glu Ala Cys Lys Asp Leu Glu Leu Ala Cys Glu Thr Ile Glu
    1570                1575                1580                
Ile Thr Ala Ala Pro Lys Cys Lys Glu Met Gln Asn Ser Leu Asn Asn
1585                1590                1595                1600
Asp Lys Asn Leu Val Ser Ile Glu Thr Val Val Pro Pro Lys Leu Leu
                1605                1610                1615    
Ser Asp Asn Leu Cys Arg Gln Thr Glu Asn Leu Lys Thr Ser Lys Ser
            1620                1625                1630        
Ile Phe Leu Lys Val Lys Val His Glu Asn Val Glu Lys Glu Thr Ala
        1635                1640                1645            
Lys Ser Pro Ala Thr Cys Tyr Thr Asn Gln Ser Pro Tyr Ser Val Ile
    1650                1655                1660                
Glu Asn Ser Ala Leu Ala Phe Tyr Thr Ser Cys Ser Arg Lys Thr Ser
1665                1670                1675                1680
Val Ser Gln Thr Ser Leu Leu Glu Ala Lys Lys Trp Leu Arg Glu Gly
                1685                1690                1695    
Ile Phe Asp Gly Gln Pro Glu Arg Ile Asn Thr Ala Asp Tyr Val Gly
            1700                1705                1710        
Asn Tyr Leu Tyr Glu Asn Asn Ser Asn Ser Thr Ile Ala Glu Asn Asp
        1715                1720                1725            
Lys Asn His Leu Ser Glu Lys Gln Asp Thr Tyr Leu Ser Asn Ser Ser
    1730                1735                1740                
Met Ser Asn Ser Tyr Ser Tyr His Ser Asp Glu Val Tyr Asn Asp Ser
1745                1750                1755                1760
Arg Ile Leu Ser Lys Asn Asn Leu Asp Ser Gly Ile Glu Pro Val Leu
                1765                1770                1775    
Lys Asn Val Glu Asp Gln Lys Asn Thr Ser Phe Ser Lys Val Ile Ser
            1780                1785                1790        
Asn Val Lys Asp Ala Asn Ala Tyr Pro Gln Thr Val Asn Glu Asp Ile
        1795                1800                1805            
Cys Val Glu Glu Leu Val Thr Ser Ser Ser Pro Cys Lys Asn Lys Asn
    1810                1815                1820                
Ala Ala Ile Lys Leu Ser Ile Ser Asn Ser Asn Asn Phe Glu Val Gly
1825                1830                1835                1840
Pro Pro Ala Phe Arg Ile Ala Ser Gly Lys Ile Val Cys Val Ser His
                1845                1850                1855    
Glu Thr Ile Lys Lys Val Lys Asp Ile Phe Thr Asp Ser Phe Ser Lys
            1860                1865                1870        
Val Ile Lys Glu Asn Asn Glu Asn Lys Ser Lys Ile Cys Gln Thr Lys
        1875                1880                1885            
Ile Met Ala Gly Cys Tyr Glu Ala Leu Asp Asp Ser Glu Asp Ile Leu
    1890                1895                1900                
His Asn Ser Leu Asp Asn Asp Glu Cys Ser Thr His Ser His Lys Val
1905                1910                1915                1920
Phe Ala Asp Ile Gln Ser Glu Glu Ile Leu Gln His Asn Gln Asn Met
                1925                1930                1935    
Ser Gly Leu Glu Lys Val Ser Lys Ile Ser Pro Cys Asp Val Ser Leu
            1940                1945                1950        
Glu Thr Ser Asp Ile Cys Lys Cys Ser Ile Gly Lys Leu His Lys Ser
        1955                1960                1965            
Val Ser Ser Ala Asn Thr Cys Gly Ile Phe Ser Thr Ala Ser Gly Lys
    1970                1975                1980                
Ser Val Gln Val Ser Asp Ala Ser Leu Gln Asn Ala Arg Gln Val Phe
1985                1990                1995                2000
Ser Glu Ile Glu Asp Ser Thr Lys Gln Val Phe Ser Lys Val Leu Phe
                2005                2010                2015    
Lys Ser Asn Glu His Ser Asp Gln Leu Thr Arg Glu Glu Asn Thr Ala
            2020                2025                2030        
Ile Arg Thr Pro Glu His Leu Ile Ser Gln Lys Gly Phe Ser Tyr Asn
        2035                2040                2045            
Val Val Asn Ser Ser Ala Phe Ser Gly Phe Ser Thr Ala Ser Gly Lys
    2050                2055                2060                
Gln Val Ser Ile Leu Glu Ser Ser Leu His Lys Val Lys Gly Val Leu
2065                2070                2075                2080
Glu Glu Phe Asp Leu Ile Arg Thr Glu His Ser Leu His Tyr Ser Pro
                2085                2090                2095    
Thr Ser Arg Gln Asn Val Ser Lys Ile Leu Pro Arg Val Asp Lys Arg
            2100                2105                2110        
Asn Pro Glu His Cys Val Asn Ser Glu Met Glu Lys Thr Cys Ser Lys
        2115                2120                2125            
Glu Phe Lys Leu Ser Asn Asn Leu Asn Val Glu Gly Gly Ser Ser Glu
    2130                2135                2140                
Asn Asn His Ser Ile Lys Val Ser Pro Tyr Leu Ser Gln Phe Gln Gln
2145                2150                2155                2160
Asp Lys Gln Gln Leu Val Leu Gly Thr Lys Val Ser Leu Val Glu Asn
                2165                2170                2175    
Ile His Val Leu Gly Lys Glu Gln Ala Ser Pro Lys Asn Val Lys Met
            2180                2185                2190        
Glu Ile Gly Lys Thr Glu Thr Phe Ser Asp Val Pro Val Lys Thr Asn
        2195                2200                2205            
Ile Glu Val Cys Ser Thr Tyr Ser Lys Asp Ser Glu Asn Tyr Phe Glu
    2210                2215                2220                
Thr Glu Ala Val Glu Ile Ala Lys Ala Phe Met Glu Asp Asp Glu Leu
2225                2230                2235                2240
Thr Asp Ser Lys Leu Pro Ser His Ala Thr His Ser Leu Phe Thr Cys
                2245                2250                2255    
Pro Glu Asn Glu Xaa Met Val Leu Ser Asn Ser Arg Ile Gly Lys Arg
            2260                2265                2270        
Arg Gly Glu Pro Leu Ile Leu Val Gly Glu Pro Ser Ile Lys Arg Asn
        2275                2280                2285            
Leu Leu Asn Glu Phe Asp Arg Ile Ile Glu Asn Gln Glu Lys Ser Leu
    2290                2295                2300                
Lys Ala Ser Lys Ser Thr Pro Asp Gly Thr Ile Lys Asp Arg Arg Leu
2305                2310                2315                2320
Phe Met His His Val Ser Leu Glu Pro Ile Thr Cys Val Pro Phe Arg
                2325                2330                2335    
Thr Thr Lys Glu Arg Gln Glu Ile Gln Asn Pro Asn Phe Thr Ala Pro
            2340                2345                2350        
Gly Gln Glu Phe Leu Ser Lys Ser His Leu Tyr Glu His Leu Thr Leu
        2355                2360                2365            
Glu Lys Ser Ser Ser Asn Leu Ala Val Ser Gly His Pro Phe Tyr Gln
    2370                2375                2380                
Val Ser Ala Thr Arg Asn Glu Lys Met Arg His Leu Ile Thr Thr Gly
2385                2390                2395                2400
Arg Pro Thr Lys Val Phe Val Pro Pro Phe Lys Thr Lys Ser His Phe
                2405                2410                2415    
His Arg Val Glu Gln Cys Val Arg Asn Ile Asn Leu Glu Glu Asn Arg
            2420                2425                2430        
Gln Lys Gln Asn Ile Asp Gly His Gly Ser Asp Asp Ser Lys Asn Lys
        2435                2440                2445            
Ile Asn Asp Asn Glu Ile His Gln Phe Asn Lys Asn Asn Ser Asn Gln
    2450                2455                2460                
Ala Ala Ala Val Thr Phe Thr Lys Cys Glu Glu Glu Pro Leu Asp Leu
2465                2470                2475                2480
Ile Thr Ser Leu Gln Asn Ala Arg Asp Ile Gln Asp Met Arg Ile Lys
                2485                2490                2495    
Lys Lys Gln Arg Gln Arg Val Phe Pro Gln Pro Gly Ser Leu Tyr Leu
            2500                2505                2510        
Ala Lys Thr Ser Thr Leu Pro Arg Ile Ser Leu Lys Ala Ala Val Gly
        2515                2520                2525            
Gly Gln Val Pro Ser Ala Cys Ser His Lys Gln Leu Tyr Thr Tyr Gly
    2530                2535                2540                
Val Ser Lys His Cys Ile Lys Ile Asn Ser Lys Asn Ala Glu Ser Phe
2545                2550                2555                2560
Gln Phe His Thr Glu Asp Tyr Phe Gly Lys Glu Ser Leu Trp Thr Gly
                2565                2570                2575    
Lys Gly Ile Gln Leu Ala Asp Gly Gly Trp Leu Ile Pro Ser Asn Asp
            2580                2585                2590        
Gly Lys Ala Gly Lys Glu Glu Phe Tyr Arg Ala Leu Cys Asp Thr Pro
        2595                2600                2605            
Gly Val Asp Pro Lys Leu Ile Ser Arg Ile Trp Val Tyr Asn His Tyr
    2610                2615                2620                
Arg Trp Ile Ile Trp Lys Leu Ala Ala Met Glu Cys Ala Phe Pro Lys
2625                2630                2635                2640
Glu Phe Ala Asn Arg Cys Leu Ser Pro Glu Arg Val Leu Leu Gln Leu
                2645                2650                2655    
Lys Tyr Arg Tyr Asp Thr Glu Ile Asp Arg Ser Arg Arg Ser Ala Ile
            2660                2665                2670        
Lys Lys Ile Met Glu Arg Asp Asp Thr Ala Ala Lys Thr Leu Val Leu
        2675                2680                2685            
Cys Val Ser Asp Ile Ile Ser Leu Ser Ala Asn Ile Ser Glu Thr Ser
    2690                2695                2700                
Ser Asn Lys Thr Ser Ser Ala Asp Thr Gln Lys Val Ala Ile Ile Glu
2705                2710                2715                2720
Leu Thr Asp Gly Trp Tyr Ala Val Lys Ala Gln Leu Asp Pro Pro Leu
                2725                2730                2735    
Leu Ala Val Leu Lys Asn Gly Arg Leu Thr Val Gly Gln Lys Ile Ile
            2740                2745                2750        
Leu His Gly Ala Glu Leu Val Gly Ser Pro Asp Ala Cys Thr Pro Leu
        2755                2760                2765            
Glu Ala Pro Glu Ser Leu Met Leu Lys Ile Ser Ala Asn Ser Thr Arg
    2770                2775                2780                
Pro Ala Arg Trp Tyr Thr Lys Leu Gly Phe Phe Pro Asp Pro Arg Pro
2785                2790                2795                2800
Phe Pro Leu Pro Leu Ser Ser Leu Phe Ser Asp Gly Gly Asn Val Gly
                2805                2810                2815    
Cys Val Asp Val Ile Ile Gln Arg Ala Tyr Pro Ile Gln Trp Met Glu
            2820                2825                2830        
Lys Thr Ser Ser Gly Leu Tyr Ile Phe Arg Asn Glu Arg Glu Glu Glu
        2835                2840                2845            
Lys Glu Ala Ala Lys Tyr Val Glu Ala Gln Gln Lys Arg Leu Glu Ala
    2850                2855                2860                
Leu Phe Thr Lys Ile Gln Glu Glu Phe Glu Glu His Glu Glu Asn Thr
2865                2870                2875                2880
Thr Lys Pro Tyr Leu Pro Ser Arg Ala Leu Thr Arg Gln Gln Val Arg
                2885                2890                2895    
Ala Leu Gln Asp Gly Ala Glu Leu Tyr Glu Ala Val Lys Asn Ala Ala
            2900                2905                2910        
Asp Pro Ala Tyr Leu Glu Gly Tyr Phe Ser Glu Glu Gln Leu Arg Ala
        2915                2920                2925            
Leu Asn Asn His Arg Gln Met Leu Asn Asp Lys Lys Gln Ala Gln Ile
    2930                2935                2940                
Gln Leu Glu Ile Arg Lys Ala Met Glu Ser Ala Glu Gln Lys Glu Gln
2945                2950                2955                2960
Gly Leu Ser Arg Asp Val Thr Thr Val Trp Lys Leu Arg Ile Val Ser
                2965                2970                2975    
Tyr Ser Lys Lys Glu Lys Asp Ser Val Ile Leu Ser Ile Trp Arg Pro
            2980                2985                2990        
Ser Ser Asp Leu Tyr Ser Leu Leu Thr Glu Gly Lys Arg Tyr Arg Ile
        2995                3000                3005            
Tyr His Leu Ala Thr Ser Lys Ser Lys Ser Lys Ser Glu Arg Ala Asn
    3010                3015                3020                
Ile Gln Leu Ala Ala Thr Lys Lys Thr Gln Tyr Gln Gln Leu Pro Val
3025                3030                3035                3040
Ser Asp Glu Ile Leu Phe Gln Ile Tyr Gln Pro Arg Glu Pro Leu His
                3045                3050                3055    
Phe Ser Lys Phe Leu Asp Pro Asp Phe Gln Pro Ser Cys Ser Glu Val
            3060                3065                3070        
Asp Leu Ile Gly Phe Val Val Ser Val Val Lys Lys Thr Gly Leu Ala
        3075                3080                3085            
Pro Phe Val Tyr Leu Ser Asp Glu Cys Tyr Asn Leu Leu Ala Ile Lys
    3090                3095                3100                
Phe Trp Ile Asp Leu Asn Glu Asp Ile Ile Lys Pro His Met Leu Ile
3105                3110                3115                3120
Ala Ala Ser Asn Leu Gln Trp Arg Pro Glu Ser Lys Ser Gly Leu Leu
                3125                3130                3135    
Thr Leu Phe Ala Gly Asp Phe Ser Val Phe Ser Ala Ser Pro Lys Glu
            3140                3145                3150        
Gly His Phe Gln Glu Thr Phe Asn Lys Met Lys Asn Thr Val Glu Asn
        3155                3160                3165            
Ile Asp Ile Leu Cys Asn Glu Ala Glu Asn Lys Leu Met His Ile Leu
    3170                3175                3180                
His Ala Asn Asp Pro Lys Trp Ser Thr Pro Thr Lys Asp Cys Thr Ser
3185                3190                3195                3200
Gly Pro Tyr Thr Ala Gln Ile Ile Pro Gly Thr Gly Asn Lys Leu Leu
                3205                3210                3215    
Met Ser Ser Pro Asn Cys Glu Ile Tyr Tyr Gln Ser Pro Leu Ser Leu
            3220                3225                3230        
Cys Met Ala Lys Arg Lys Ser Val Ser Thr Pro Val Ser Ala Gln Met
        3235                3240                3245            
Thr Ser Lys Ser Cys Lys Gly Glu Lys Glu Ile Asp Asp Gln Lys Asn
    3250                3255                3260                
Cys Lys Lys Arg Arg Ala Leu Asp Phe Leu Ser Arg Leu Pro Leu Pro
3265                3270                3275                3280
Pro Pro Val Ser Pro Ile Cys Thr Phe Val Ser Pro Ala Ala Gln Lys
                3285                3290                3295    
Ala Phe Gln Pro Pro Arg Ser Cys Gly Thr Lys Tyr Glu Thr Pro Ile
            3300                3305                3310        
Lys Lys Lys Glu Leu Asn Ser Pro Gln Met Thr Pro Phe Lys Lys Phe
        3315                3320                3325            
Asn Glu Ile Ser Leu Leu Glu Ser Asn Ser Ile Ala Asp Glu Glu Leu
    3330                3335                3340                
Ala Leu Ile Asn Thr Gln Ala Leu Leu Ser Gly Ser Thr Gly Glu Lys
3345                3350                3355                3360
Gln Phe Ile Ser Val Ser Glu Ser Thr Arg Thr Ala Pro Thr Ser Ser
                3365                3370                3375    
Glu Asp Tyr Leu Arg Leu Lys Arg Arg Cys Thr Thr Ser Leu Ile Lys
            3380                3385                3390        
Glu Gln Glu Ser Ser Gln Ala Ser Thr Glu Glu Cys Glu Lys Asn Lys
        3395                3400                3405            
Gln Asp Thr Ile Thr Thr Lys Lys Tyr Ile
    3410                3415            


<210> 179
<211> 388
<212> PRT
<213> Homo sapiens

<400> 179
Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg
 1               5                  10                  15      
Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys
            20                  25                  30          
Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro
        35                  40                  45              
His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys
    50                  55                  60                  
Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu
65                  70                  75                  80  
Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr
                85                  90                  95      
Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu
            100                 105                 110         
Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu
        115                 120                 125             
Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp
    130                 135                 140                 
Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu
145                 150                 155                 160 
Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr
                165                 170                 175     
Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe
            180                 185                 190         
Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val
        195                 200                 205             
His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser
    210                 215                 220                 
Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp
225                 230                 235                 240 
Val Lys Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu
                245                 250                 255     
Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys
            260                 265                 270         
Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr
        275                 280                 285             
Tyr Thr Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val
    290                 295                 300                 
His Pro Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu
305                 310                 315                 320 
Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu
                325                 330                 335     
Ala Ser Ala Ala Tyr Pro Asp Pro Ser Lys Gln Lys Pro Met Ala Lys
            340                 345                 350         
Gly Leu Pro Arg Ile Gln Asn Gln Arg Arg Ser Ser His Pro Gly Trp
        355                 360                 365             
Ile Ser Val Trp Gly Lys Ser Ser Leu Trp Arg Ser Thr Gln Met Gln
    370                 375                 380                 
Thr Ala Cys Met
385             


<210> 180
<211> 54
<212> PRT
<213> Homo sapiens

<400> 180
Met Glu Trp Asn Gly Met Ala Trp Asn Arg Ile Lys Trp Asn Gly Ile
 1               5                  10                  15      
Asn Ser Ser Gly Met Glu Trp Asn Gly Met Glu Trp Asn Ala Val Gln
            20                  25                  30          
Cys Asn Arg Met Glu Trp Asn Glu Leu Glu Leu Thr Gly Met Glu Trp
        35                  40                  45              
Asn Gly Met His Leu Asn
    50                  


<210> 181
<211> 641
<212> PRT
<213> Homo sapiens

<400> 181
Asp Lys Pro Thr Ala Asn Ile Ile Leu Asn Gly Gln Lys Leu Gln Ala
 1               5                  10                  15      
Phe Pro Leu Lys Thr Gly Thr Arg Gln Gly Cys Pro Leu Ser Pro Leu
            20                  25                  30          
Leu Phe Asn Ile Val Leu Glu Val Leu Ala Arg Ala Ile Arg Gln Glu
        35                  40                  45              
Lys Glu Ile Lys Gly Ile Gln Leu Gly Lys Glu Glu Val Lys Leu Ser
    50                  55                  60                  
Leu Phe Ala Asp Asp Met Ile Val Tyr Leu Glu Asn Pro Ile Val Ser
65                  70                  75                  80  
Ala Gln Asn Leu Leu Lys Leu Ile Ser Asn Phe Ser Lys Val Ser Gly
                85                  90                  95      
Tyr Lys Ile Asn Val Gln Lys Ser Gln Ala Phe Leu Tyr Thr Asn Asn
            100                 105                 110         
Arg Gln Thr Glu Ser Gln Ile Met Ser Glu Leu Pro Phe Thr Ile Ala
        115                 120                 125             
Ser Lys Arg Ile Lys Tyr Leu Gly Ile Gln Leu Thr Arg Asp Val Lys
    130                 135                 140                 
Asp Leu Phe Lys Glu Asn Tyr Lys Pro Leu Leu Lys Glu Ile Lys Glu
145                 150                 155                 160 
Asp Thr Asn Lys Trp Lys Asn Ile Pro Cys Ser Trp Val Gly Arg Ile
                165                 170                 175     
Asn Ile Val Lys Met Ala Ile Leu Pro Lys Val Ile Tyr Arg Phe Asn
            180                 185                 190         
Ala Ile Pro Ile Lys Leu Pro Met Thr Phe Phe Thr Glu Leu Glu Lys
        195                 200                 205             
Thr Thr Leu Lys Phe Ile Trp Asn Gln Lys Arg Ala Arg Ile Ala Lys
    210                 215                 220                 
Ser Ile Leu Ser Gln Lys Asn Lys Ala Gly Gly Ile Thr Leu Pro Asp
225                 230                 235                 240 
Phe Lys Leu Tyr Tyr Lys Ala Thr Val Thr Lys Thr Ala Trp Tyr Trp
                245                 250                 255     
Tyr Gln Asn Arg Asp Ile Asp Gln Trp Asn Arg Thr Glu Pro Ser Glu
            260                 265                 270         
Ile Met Pro His Ile Tyr Asn Tyr Leu Ile Phe Asp Lys Pro Glu Lys
        275                 280                 285             
Asn Lys Gln Trp Gly Lys Asp Ser Leu Phe Asn Lys Trp Cys Trp Glu
    290                 295                 300                 
Asn Trp Leu Ala Ile Cys Arg Lys Leu Lys Leu Asp Pro Phe Leu Thr
305                 310                 315                 320 
Pro Tyr Thr Lys Ile Asn Ser Arg Trp Ile Lys Asp Leu Asn Val Arg
                325                 330                 335     
Pro Lys Thr Ile Lys Thr Leu Glu Glu Asn Leu Gly Ile Thr Ile Glu
            340                 345                 350         
Asp Ile Gly Val Gly Lys Asp Phe Met Ser Lys Thr Pro Lys Ala Met
        355                 360                 365             
Ala Thr Lys Ala Lys Ile Asp Lys Trp Asp Leu Ile Lys Leu Lys Ser
    370                 375                 380                 
Phe Cys Thr Ala Lys Glu Thr Thr Ile Arg Val Asn Arg Gln Pro Thr
385                 390                 395                 400 
Thr Trp Glu Lys Ile Phe Ala Thr Tyr Ser Ser Asp Lys Gly Leu Ile
                405                 410                 415     
Ser Arg Ile Tyr Asn Glu Leu Lys Gln Ile Tyr Lys Lys Lys Thr Asn
            420                 425                 430         
Asn Pro Ile Lys Lys Trp Ala Lys Asp Met Asn Arg His Phe Ser Lys
        435                 440                 445             
Glu Asp Ile Tyr Ala Ala Lys Lys His Met Lys Lys Cys Ser Ser Ser
    450                 455                 460                 
Leu Ala Ile Arg Glu Met Gln Ile Lys Thr Thr Met Arg Tyr His Leu
465                 470                 475                 480 
Thr Pro Val Arg Met Ala Ile Ile Lys Lys Ser Gly Asn Asn Arg Cys
                485                 490                 495     
Trp Arg Gly Cys Gly Glu Ile Gly Thr Leu Leu His Cys Trp Trp Asp
            500                 505                 510         
Cys Lys Leu Val Gln Pro Leu Trp Lys Ser Val Trp Arg Phe Leu Arg
        515                 520                 525             
Asp Leu Glu Leu Glu Ile Pro Phe Asp Pro Ala Ile Pro Leu Leu Gly
    530                 535                 540                 
Ile Tyr Pro Asn Asp Tyr Lys Ser Cys Cys Tyr Lys Asp Thr Cys Thr
545                 550                 555                 560 
Arg Met Phe Ile Ala Ala Leu Phe Thr Ile Ala Lys Thr Trp Asn Gln
                565                 570                 575     
Pro Lys Cys Pro Thr Met Ile Asp Trp Ile Lys Lys Met Trp His Ile
            580                 585                 590         
Tyr Thr Met Glu Tyr Tyr Ala Ala Ile Lys Asn Asp Glu Phe Met Ser
        595                 600                 605             
Phe Val Gly Thr Trp Met Lys Leu Glu Thr Ile Ile Leu Ser Lys Leu
    610                 615                 620                 
Ser Gln Glu Gln Lys Thr Lys His Arg Ile Phe Ser Leu Ile Gly Gly
625                 630                 635                 640 
Asn
    


<210> 182
<211> 435
<212> PRT
<213> Homo sapiens

<400> 182
Tyr Lys Cys Gly Gly Ile Asp Lys Arg Thr Ile Glu Lys Phe Glu Lys
 1               5                  10                  15      
Glu Ala Ala Glu Met Gly Lys Gly Ser Phe Lys Tyr Ala Trp Val Leu
            20                  25                  30          
Asp Lys Leu Lys Ala Glu Arg Glu Arg Gly Ile Thr Ile Asp Ile Ser
        35                  40                  45              
Leu Trp Lys Phe Glu Thr Thr Lys Tyr Tyr Ile Thr Ile Ile Asp Ala
    50                  55                  60                  
Pro Gly His Arg Asp Phe Ile Lys Asn Met Ile Thr Gly Thr Ser Gln
65                  70                  75                  80  
Ala Asp Cys Ala Val Leu Ile Val Ala Ala Gly Val Gly Glu Phe Glu
                85                  90                  95      
Ala Gly Ile Ser Lys Asn Gly Gln Thr Arg Glu His Ala Leu Leu Ala
            100                 105                 110         
Tyr Thr Leu Gly Val Lys Gln Leu Ile Val Gly Val Asn Lys Met Asp
        115                 120                 125             
Ser Thr Glu Pro Ala Tyr Ser Glu Lys Arg Tyr Asp Glu Ile Val Lys
    130                 135                 140                 
Glu Val Ser Ala Tyr Ile Lys Lys Ile Gly Tyr Asn Pro Ala Thr Val
145                 150                 155                 160 
Pro Phe Val Pro Ile Ser Gly Trp His Gly Asp Asn Met Leu Glu Pro
                165                 170                 175     
Ser Pro Asn Met Pro Trp Phe Lys Gly Trp Lys Val Glu Arg Lys Glu
            180                 185                 190         
Gly Asn Ala Ser Gly Val Ser Leu Leu Glu Ala Leu Asp Thr Ile Leu
        195                 200                 205             
Pro Pro Thr Arg Pro Thr Asp Lys Pro Leu Arg Leu Pro Leu Gln Asp
    210                 215                 220                 
Val Tyr Lys Ile Gly Gly Ile Gly Thr Val Pro Val Gly Arg Val Glu
225                 230                 235                 240 
Thr Gly Ile Leu Arg Pro Gly Met Val Val Thr Phe Ala Pro Val Asn
                245                 250                 255     
Ile Thr Thr Glu Val Lys Ser Val Glu Met His His Glu Ala Leu Ser
            260                 265                 270         
Glu Ala Leu Pro Gly Asp Asn Val Gly Phe Asn Val Lys Asn Val Ser
        275                 280                 285             
Val Lys Asp Ile Arg Arg Gly Asn Val Cys Gly Asp Ser Lys Ser Asp
    290                 295                 300                 
Pro Pro Gln Glu Ala Ala Gln Phe Thr Ser Gln Val Ile Ile Leu Asn
305                 310                 315                 320 
His Pro Gly Gln Ile Ser Ala Gly Tyr Ser Pro Val Ile Asp Cys His
                325                 330                 335     
Thr Ala His Ile Ala Cys Lys Phe Ala Glu Leu Lys Glu Lys Ile Asp
            340                 345                 350         
Arg Arg Ser Gly Lys Lys Leu Glu Asp Asn Pro Lys Ser Leu Lys Ser
        355                 360                 365             
Gly Asp Ala Ala Ile Val Glu Met Val Pro Gly Lys Pro Met Cys Val
    370                 375                 380                 
Glu Ser Phe Ser Gln Tyr Pro Pro Leu Gly Arg Phe Ala Val Pro Asp
385                 390                 395                 400 
Met Arg Gln Thr Val Ala Val Gly Val Ile Lys Asn Val Glu Lys Lys
                405                 410                 415     
Ser Gly Gly Ala Gly Lys Val Thr Lys Ser Ala Gln Lys Ala Gln Lys
            420                 425                 430         
Ala Gly Lys
        435 


<210> 183
<211> 126
<212> PRT
<213> Homo sapiens

<400> 183
Phe Ser Thr Ala Ser Ala Val Pro Leu Ala Lys Thr Asp Thr Trp Pro
 1               5                  10                  15      
Lys Asp Val Gly Ile Leu Ala Leu Glu Val Tyr Phe Pro Ala Gln Tyr
            20                  25                  30          
Val Asp Gln Thr Asp Leu Glu Lys Tyr Asn Asn Val Glu Ala Gly Lys
        35                  40                  45              
Tyr Thr Val Gly Leu Gly Gln Thr Arg Met Gly Phe Cys Ser Val Gln
    50                  55                  60                  
Glu Asp Ile Asn Ser Leu Cys Leu Thr Val Val Gln Arg Leu Met Glu
65                  70                  75                  80  
Arg Ile Gln Leu Pro Trp Asp Ser Val Gly Arg Leu Glu Val Gly Thr
                85                  90                  95      
Glu Thr Ile Ile Asp Lys Ser Lys Ala Val Lys Thr Val Leu Met Glu
            100                 105                 110         
Leu Phe Gln Asp Ser Gly Asn Thr Asp Ile Glu Gly Ile Asp
        115                 120                 125     


<210> 184
<211> 2644
<212> PRT
<213> Homo sapiens

<400> 184
Met Gly Glu His Gly Leu Glu Leu Ala Ser Met Ile Pro Ala Leu Arg
 1               5                  10                  15      
Glu Leu Gly Ser Ala Thr Pro Glu Glu Tyr Asn Thr Val Val Gln Lys
            20                  25                  30          
Pro Arg Gln Ile Leu Cys Gln Phe Ile Asp Arg Ile Leu Thr Asp Val
        35                  40                  45              
Asn Val Val Ala Val Glu Leu Val Lys Lys Thr Asp Ser Gln Pro Thr
    50                  55                  60                  
Ser Val Met Leu Leu Asp Phe Ile Gln His Ile Met Lys Ser Ser Pro
65                  70                  75                  80  
Leu Met Phe Val Asn Val Ser Gly Ser His Glu Ala Lys Gly Ser Cys
                85                  90                  95      
Ile Glu Phe Ser Asn Trp Ile Ile Thr Arg Leu Leu Arg Ile Ala Ala
            100                 105                 110         
Thr Pro Ser Cys His Leu Leu His Lys Lys Ile Cys Glu Val Ile Cys
        115                 120                 125             
Ser Leu Leu Phe Leu Phe Lys Ser Lys Ser Pro Ala Ile Phe Gly Val
    130                 135                 140                 
Leu Thr Lys Glu Leu Leu Gln Leu Phe Glu Asp Leu Val Tyr Leu His
145                 150                 155                 160 
Arg Arg Asn Val Met Gly His Ala Val Glu Trp Pro Val Val Met Ser
                165                 170                 175     
Arg Phe Leu Ser Gln Leu Asp Glu His Met Gly Tyr Leu Gln Ser Ala
            180                 185                 190         
Pro Leu Gln Leu Met Ser Met Gln Asn Leu Glu Phe Ile Glu Val Thr
        195                 200                 205             
Leu Leu Met Val Leu Thr Arg Ile Ile Ala Ile Val Phe Phe Arg Arg
    210                 215                 220                 
Gln Glu Leu Leu Leu Trp Gln Ile Gly Cys Val Leu Leu Glu Tyr Gly
225                 230                 235                 240 
Ser Pro Lys Ile Lys Ser Leu Ala Ile Ser Phe Leu Thr Glu Leu Phe
                245                 250                 255     
Gln Leu Gly Gly Leu Pro Ala Gln Pro Ala Ser Thr Phe Phe Ser Ser
            260                 265                 270         
Phe Leu Glu Leu Leu Lys His Leu Val Glu Met Asp Thr Asp Gln Leu
        275                 280                 285             
Lys Leu Tyr Glu Glu Pro Leu Ser Lys Leu Ile Lys Thr Leu Phe Pro
    290                 295                 300                 
Phe Glu Ala Glu Ala Tyr Arg Asn Ile Glu Pro Val Tyr Leu Asn Met
305                 310                 315                 320 
Leu Leu Glu Lys Leu Cys Val Met Phe Glu Asp Gly Val Leu Met Arg
                325                 330                 335     
Leu Lys Ser Asp Leu Leu Lys Ala Ala Leu Cys His Leu Leu Gln Tyr
            340                 345                 350         
Phe Leu Lys Phe Val Pro Ala Gly Tyr Glu Ser Ala Leu Gln Val Arg
        355                 360                 365             
Lys Val Tyr Val Arg Asn Ile Cys Lys Ala Leu Leu Asp Val Leu Gly
    370                 375                 380                 
Ile Glu Val Asp Ala Glu Tyr Leu Leu Gly Pro Leu Tyr Ala Ala Leu
385                 390                 395                 400 
Lys Met Glu Ser Met Glu Ile Ile Glu Glu Ile Gln Cys Gln Thr Gln
                405                 410                 415     
Gln Glu Asn Leu Ser Ser Asn Ser Asp Gly Ile Ser Pro Lys Arg Arg
            420                 425                 430         
Arg Leu Ser Ser Ser Leu Asn Pro Ser Lys Arg Ala Pro Lys Gln Thr
        435                 440                 445             
Glu Glu Ile Lys His Val Asp Met Asn Gln Lys Ser Ile Leu Trp Ser
    450                 455                 460                 
Ala Leu Lys Gln Lys Ala Glu Ser Leu Gln Ile Ser Leu Glu Tyr Ser
465                 470                 475                 480 
Gly Leu Lys Asn Pro Val Ile Glu Met Leu Glu Gly Ile Ala Val Val
                485                 490                 495     
Leu Gln Leu Thr Ala Leu Cys Thr Val His Cys Ser His Gln Asn Met
            500                 505                 510         
Asn Cys Arg Thr Phe Lys Asp Cys Gln His Lys Ser Lys Lys Lys Pro
        515                 520                 525             
Ser Val Val Ile Thr Trp Met Ser Leu Asp Phe Tyr Thr Lys Val Leu
    530                 535                 540                 
Lys Ser Cys Arg Ser Leu Leu Glu Ser Val Gln Lys Leu Asp Leu Glu
545                 550                 555                 560 
Ala Thr Ile Asp Lys Val Val Lys Ile Tyr Asp Ala Leu Ile Tyr Met
                565                 570                 575     
Gln Val Asn Ser Ser Phe Glu Asp His Ile Leu Glu Asp Leu Cys Gly
            580                 585                 590         
Met Leu Ser Leu Pro Trp Ile Tyr Ser His Ser Asp Asp Gly Cys Leu
        595                 600                 605             
Lys Leu Thr Thr Phe Ala Ala Asn Leu Leu Thr Leu Ser Cys Arg Ile
    610                 615                 620                 
Ser Asp Ser Tyr Ser Pro Gln Ala Gln Ser Arg Cys Val Phe Leu Leu
625                 630                 635                 640 
Thr Leu Phe Pro Arg Arg Ile Phe Leu Glu Trp Arg Thr Ala Val Tyr
                645                 650                 655     
Asn Trp Ala Leu Gln Ser Ser His Glu Val Ile Arg Ala Ser Cys Val
            660                 665                 670         
Ser Gly Phe Phe Ile Leu Leu Gln Gln Gln Asn Ser Cys Asn Arg Val
        675                 680                 685             
Pro Lys Ile Leu Ile Asp Lys Val Lys Asp Asp Ser Asp Ile Val Lys
    690                 695                 700                 
Lys Glu Phe Ala Ser Ile Leu Gly Gln Leu Val Cys Thr Leu His Gly
705                 710                 715                 720 
Met Phe Tyr Leu Thr Ser Ser Leu Thr Glu Pro Phe Ser Glu His Gly
                725                 730                 735     
His Val Asp Leu Phe Cys Arg Asn Leu Lys Ala Thr Ser Gln His Glu
            740                 745                 750         
Cys Ser Ser Ser Gln Leu Lys Ala Ser Val Cys Lys Pro Phe Leu Phe
        755                 760                 765             
Leu Leu Lys Lys Lys Ile Pro Ser Pro Val Lys Leu Ala Phe Ile Asp
    770                 775                 780                 
Asn Leu His His Leu Cys Lys His Leu Asp Phe Arg Glu Asp Glu Thr
785                 790                 795                 800 
Asp Val Lys Ala Val Leu Gly Thr Leu Leu Asn Leu Met Glu Asp Pro
                805                 810                 815     
Asp Lys Asp Val Arg Val Ala Phe Ser Gly Asn Ile Lys His Ile Leu
            820                 825                 830         
Glu Ser Leu Asp Ser Glu Asp Gly Phe Ile Lys Glu Leu Phe Val Leu
        835                 840                 845             
Arg Met Lys Glu Ala Tyr Thr His Ala Gln Ile Ser Arg Asn Asn Glu
    850                 855                 860                 
Leu Lys Asp Thr Leu Ile Leu Thr Thr Gly Asp Ile Gly Arg Ala Ala
865                 870                 875                 880 
Lys Gly Asp Leu Val Pro Phe Ala Leu Leu His Leu Leu His Cys Leu
                885                 890                 895     
Leu Ser Lys Ser Ala Ser Val Ser Gly Ala Ala Tyr Thr Glu Ile Arg
            900                 905                 910         
Ala Leu Val Ala Ala Lys Ser Val Lys Leu Gln Ser Phe Phe Ser Gln
        915                 920                 925             
Tyr Lys Lys Pro Ile Cys Gln Phe Leu Val Glu Ser Leu His Ser Ser
    930                 935                 940                 
Gln Met Thr Ala Leu Pro Asn Thr Pro Cys Gln Asn Ala Asp Val Arg
945                 950                 955                 960 
Lys Gln Asp Val Ala His Gln Arg Glu Met Ala Leu Asn Thr Leu Ser
                965                 970                 975     
Glu Ile Ala Asn Val Phe Asp Phe Pro Asp Leu Asn Arg Phe Leu Thr
            980                 985                 990         
Arg Thr Leu Gln Val Leu Leu Pro Asp Leu Ala Ala Lys Ala Ser Pro
        995                 1000                1005            
Ala Ala Ser Ala Leu Ile Arg Thr Leu Gly Lys Gln Leu Asn Val Asn
    1010                1015                1020                
Arg Arg Glu Ile Leu Ile Asn Asn Phe Lys Tyr Ile Phe Ser His Leu
1025                1030                1035                1040
Val Cys Ser Cys Ser Lys Asp Glu Leu Glu Arg Ala Leu His Tyr Leu
                1045                1050                1055    
Lys Asn Glu Thr Glu Ile Glu Leu Gly Ser Leu Leu Arg Gln Asp Phe
            1060                1065                1070        
Gln Gly Leu His Asn Glu Leu Leu Leu Arg Ile Gly Glu His Tyr Gln
        1075                1080                1085            
Gln Val Phe Asn Gly Leu Ser Ile Leu Ala Ser Phe Ala Ser Ser Asp
    1090                1095                1100                
Asp Pro Tyr Gln Gly Pro Arg Asp Ile Ile Ser Pro Glu Leu Met Ala
1105                1110                1115                1120
Asp Tyr Leu Gln Pro Lys Leu Leu Gly Ile Leu Ala Phe Phe Asn Met
                1125                1130                1135    
Gln Leu Leu Ser Ser Ser Val Gly Ile Glu Asp Lys Lys Met Ala Leu
            1140                1145                1150        
Asn Ser Leu Met Ser Leu Met Lys Leu Met Gly Pro Lys His Val Ser
        1155                1160                1165            
Ser Val Arg Val Lys Met Met Thr Thr Leu Arg Thr Gly Leu Arg Phe
    1170                1175                1180                
Lys Asp Asp Phe Pro Glu Leu Cys Cys Arg Ala Trp Asp Cys Phe Val
1185                1190                1195                1200
Arg Cys Leu Asp His Ala Cys Leu Gly Ser Leu Leu Ser His Val Ile
                1205                1210                1215    
Val Ala Leu Leu Pro Leu Ile His Ile Gln Pro Lys Glu Thr Ala Ala
            1220                1225                1230        
Ile Phe His Tyr Leu Ile Ile Glu Asn Arg Asp Ala Val Gln Asp Phe
        1235                1240                1245            
Leu His Glu Ile Tyr Phe Leu Pro Asp His Pro Glu Leu Lys Lys Ile
    1250                1255                1260                
Lys Ala Val Leu Gln Glu Tyr Arg Lys Glu Thr Ser Glu Ser Thr Asp
1265                1270                1275                1280
Leu Gln Thr Thr Leu Gln Leu Ser Met Lys Ala Ile Gln His Glu Asn
                1285                1290                1295    
Val Asp Val Arg Ile His Ala Leu Thr Ser Leu Lys Glu Thr Leu Tyr
            1300                1305                1310        
Lys Asn Gln Glu Lys Leu Ile Lys Tyr Ala Thr Asp Ser Glu Thr Val
        1315                1320                1325            
Glu Pro Ile Ile Ser Gln Leu Val Thr Val Leu Leu Lys Gly Cys Gln
    1330                1335                1340                
Asp Ala Asn Ser Gln Ala Arg Leu Leu Cys Gly Glu Cys Leu Gly Glu
1345                1350                1355                1360
Leu Gly Ala Ile Asp Pro Gly Arg Leu Asp Phe Ser Thr Thr Glu Thr
                1365                1370                1375    
Gln Gly Lys Asp Phe Thr Phe Val Thr Gly Val Glu Asp Ser Ser Phe
            1380                1385                1390        
Ala Tyr Gly Leu Leu Met Glu Leu Thr Arg Ala Tyr Leu Ala Tyr Ala
        1395                1400                1405            
Asp Asn Ser Arg Ala Gln Asp Ser Ala Ala Tyr Ala Ile Gln Glu Leu
    1410                1415                1420                
Leu Ser Ile Tyr Asp Cys Arg Glu Met Glu Thr Asn Gly Pro Gly His
1425                1430                1435                1440
Gln Leu Trp Arg Arg Phe Pro Glu His Val Arg Glu Ile Leu Glu Pro
                1445                1450                1455    
His Leu Asn Thr Arg Tyr Lys Ser Ser Gln Lys Ser Thr Asp Trp Ser
            1460                1465                1470        
Gly Val Lys Lys Pro Ile Tyr Leu Ser Lys Leu Gly Ser Asn Phe Ala
        1475                1480                1485            
Glu Trp Ser Ala Ser Trp Ala Gly Tyr Leu Ile Thr Lys Val Arg His
    1490                1495                1500                
Asp Leu Ala Ser Lys Ile Phe Thr Cys Cys Ser Ile Met Met Lys His
1505                1510                1515                1520
Asp Phe Lys Val Thr Ile Tyr Leu Leu Pro His Ile Leu Val Tyr Val
                1525                1530                1535    
Leu Leu Gly Cys Asn Gln Glu Asp Gln Gln Glu Val Tyr Ala Glu Ile
            1540                1545                1550        
Met Ala Val Leu Lys His Asp Asp Gln His Thr Ile Asn Thr Gln Asp
        1555                1560                1565            
Ile Ala Ser Asp Leu Cys Gln Leu Ser Thr Gln Thr Val Phe Ser Met
    1570                1575                1580                
Leu Asp His Leu Thr Gln Trp Ala Arg His Lys Phe Gln Ala Leu Lys
1585                1590                1595                1600
Ala Glu Lys Cys Pro His Ser Lys Ser Asn Arg Asn Lys Val Asp Ser
                1605                1610                1615    
Met Val Ser Thr Val Asp Tyr Glu Asp Tyr Gln Ser Val Thr Arg Phe
            1620                1625                1630        
Leu Asp Leu Ile Pro Gln Asp Thr Leu Ala Val Ala Ser Phe Arg Ser
        1635                1640                1645            
Lys Ala Tyr Thr Arg Ala Val Met His Phe Glu Ser Phe Ile Thr Glu
    1650                1655                1660                
Lys Lys Gln Asn Ile Gln Glu His Leu Gly Phe Leu Gln Lys Leu Tyr
1665                1670                1675                1680
Ala Ala Met His Glu Pro Asp Gly Val Ala Gly Val Ser Ala Ile Arg
                1685                1690                1695    
Lys Ala Glu Pro Ser Leu Lys Glu Gln Ile Leu Glu His Glu Ser Leu
            1700                1705                1710        
Gly Leu Leu Arg Asp Ala Thr Ala Cys Tyr Asp Arg Ala Ile Gln Leu
        1715                1720                1725            
Glu Pro Asp Gln Ile Ile His Tyr His Gly Val Val Lys Ser Met Leu
    1730                1735                1740                
Gly Leu Gly Gln Leu Ser Thr Val Ile Thr Gln Val Asn Gly Val His
1745                1750                1755                1760
Ala Asn Arg Ser Glu Trp Thr Asp Glu Leu Asn Thr Tyr Arg Val Glu
                1765                1770                1775    
Ala Ala Trp Lys Leu Ser Gln Trp Asp Leu Val Glu Asn Tyr Leu Ala
            1780                1785                1790        
Ala Asp Gly Lys Ser Thr Thr Trp Ser Val Arg Leu Gly Gln Leu Leu
        1795                1800                1805            
Leu Ser Ala Lys Lys Arg Asp Ile Thr Ala Phe Tyr Asp Ser Leu Lys
    1810                1815                1820                
Leu Val Arg Ala Glu Gln Ile Val Pro Leu Ser Ala Ala Ser Phe Glu
1825                1830                1835                1840
Arg Gly Ser Tyr Gln Arg Gly Tyr Glu Tyr Ile Val Arg Leu His Met
                1845                1850                1855    
Leu Cys Glu Leu Glu His Ser Ile Lys Pro Leu Phe Gln His Ser Pro
            1860                1865                1870        
Gly Asp Ser Ser Gln Glu Asp Ser Leu Asn Trp Val Ala Arg Leu Glu
        1875                1880                1885            
Met Thr Gln Asn Ser Tyr Arg Ala Lys Glu Pro Ile Leu Ala Leu Arg
    1890                1895                1900                
Arg Ala Leu Leu Ser Leu Asn Lys Arg Pro Asp Tyr Asn Glu Met Val
1905                1910                1915                1920
Gly Glu Cys Trp Leu Gln Ser Ala Arg Val Ala Arg Lys Ala Gly His
                1925                1930                1935    
His Gln Thr Ala Tyr Asn Ala Leu Leu Asn Ala Gly Glu Ser Arg Leu
            1940                1945                1950        
Ala Glu Leu Tyr Val Glu Arg Ala Lys Trp Leu Trp Ser Lys Gly Asp
        1955                1960                1965            
Val His Gln Ala Leu Ile Val Leu Gln Lys Gly Val Glu Leu Cys Phe
    1970                1975                1980                
Pro Glu Asn Glu Thr Pro Pro Glu Gly Lys Asn Met Leu Ile His Gly
1985                1990                1995                2000
Arg Ala Met Leu Leu Val Gly Arg Phe Met Glu Glu Thr Ala Asn Phe
                2005                2010                2015    
Glu Ser Asn Ala Ile Met Lys Lys Tyr Lys Asp Val Thr Ala Cys Leu
            2020                2025                2030        
Pro Glu Trp Glu Asp Gly His Phe Tyr Leu Ala Lys Tyr Tyr Asp Lys
        2035                2040                2045            
Leu Met Pro Met Val Thr Asp Asn Lys Met Glu Lys Gln Gly Asp Leu
    2050                2055                2060                
Ile Arg Tyr Ile Val Leu His Phe Gly Arg Ser Leu Gln Tyr Gly Asn
2065                2070                2075                2080
Gln Phe Ile Tyr Gln Ser Met Pro Arg Met Leu Thr Leu Trp Leu Asp
                2085                2090                2095    
Tyr Gly Thr Lys Ala Tyr Glu Trp Glu Lys Ala Gly Arg Ser Asp Arg
            2100                2105                2110        
Val Gln Met Arg Asn Asp Leu Gly Lys Ile Asn Lys Val Ile Thr Glu
        2115                2120                2125            
His Thr Asn Tyr Leu Ala Pro Tyr Gln Phe Leu Thr Ala Phe Ser Gln
    2130                2135                2140                
Leu Ile Ser Arg Ile Cys His Ser His Asp Glu Val Phe Val Val Leu
2145                2150                2155                2160
Met Glu Ile Ile Ala Lys Val Phe Leu Ala Tyr Pro Gln Gln Ala Met
                2165                2170                2175    
Trp Met Met Thr Ala Val Ser Lys Ser Ser Tyr Pro Met Arg Val Asn
            2180                2185                2190        
Arg Cys Lys Glu Ile Leu Asn Lys Ala Ile His Met Lys Lys Ser Leu
        2195                2200                2205            
Glu Lys Phe Val Gly Asp Ala Thr Arg Leu Thr Asp Lys Leu Leu Glu
    2210                2215                2220                
Leu Cys Asn Lys Pro Val Asp Gly Ser Ser Ser Thr Leu Ser Met Ser
2225                2230                2235                2240
Thr His Phe Lys Met Leu Lys Lys Leu Val Glu Glu Ala Thr Phe Ser
                2245                2250                2255    
Glu Ile Leu Ile Pro Leu Gln Ser Val Met Ile Pro Thr Leu Pro Ser
            2260                2265                2270        
Ile Leu Gly Thr His Ala Asn His Ala Ser His Glu Pro Phe Pro Gly
        2275                2280                2285            
His Trp Ala Tyr Ile Ala Gly Phe Asp Asp Met Val Glu Ile Leu Ala
    2290                2295                2300                
Ser Leu Gln Lys Pro Lys Lys Ile Ser Leu Lys Gly Ser Asp Gly Lys
2305                2310                2315                2320
Phe Tyr Ile Met Met Cys Lys Pro Lys Asp Asp Leu Arg Lys Asp Cys
                2325                2330                2335    
Arg Leu Met Glu Phe Asn Ser Leu Ile Asn Lys Cys Leu Arg Lys Asp
            2340                2345                2350        
Ala Glu Ser Arg Arg Arg Glu Leu His Ile Arg Thr Tyr Ala Val Ile
        2355                2360                2365            
Pro Leu Asn Asp Glu Cys Gly Ile Ile Glu Trp Val Asn Asn Thr Ala
    2370                2375                2380                
Gly Leu Arg Pro Ile Leu Thr Lys Leu Tyr Lys Glu Lys Gly Val Tyr
2385                2390                2395                2400
Met Thr Gly Lys Glu Leu Arg Gln Cys Met Leu Pro Lys Ser Ala Ala
                2405                2410                2415    
Leu Ser Glu Lys Leu Lys Val Phe Arg Glu Phe Leu Leu Pro Arg His
            2420                2425                2430        
Pro Pro Ile Phe His Glu Trp Phe Leu Arg Thr Phe Pro Asp Pro Thr
        2435                2440                2445            
Ser Trp Tyr Ser Ser Arg Ser Ala Tyr Cys Arg Ser Thr Ala Val Met
    2450                2455                2460                
Ser Met Val Gly Tyr Ile Leu Gly Leu Gly Asp Arg His Gly Glu Asn
2465                2470                2475                2480
Ile Leu Phe Asp Ser Leu Thr Gly Glu Cys Val His Val Asp Phe Asn
                2485                2490                2495    
Cys Leu Phe Asn Lys Gly Glu Thr Phe Glu Val Pro Glu Ile Val Pro
            2500                2505                2510        
Phe Arg Leu Thr His Asn Met Val Asn Gly Met Gly Pro Met Gly Thr
        2515                2520                2525            
Glu Gly Leu Phe Arg Arg Ala Cys Glu Val Thr Met Arg Leu Met Arg
    2530                2535                2540                
Asp Gln Arg Glu Pro Leu Met Ser Val Leu Lys Thr Phe Leu His Asp
2545                2550                2555                2560
Pro Leu Val Glu Trp Ser Lys Pro Val Lys Gly His Ser Lys Ala Pro
                2565                2570                2575    
Leu Asn Glu Thr Gly Glu Val Val Asn Glu Lys Ala Lys Thr His Val
            2580                2585                2590        
Leu Asp Ile Glu Gln Arg Leu Gln Gly Val Ile Lys Thr Arg Asn Arg
        2595                2600                2605            
Val Thr Gly Leu Pro Leu Ser Ile Glu Gly His Val His Tyr Leu Ile
    2610                2615                2620                
Gln Glu Ala Thr Asp Glu Asn Leu Leu Cys Gln Met Tyr Leu Gly Trp
2625                2630                2635                2640
Thr Pro Tyr Met
                


<210> 185
<211> 154
<212> PRT
<213> Homo sapiens

<400> 185
Met Ala Thr Lys Ala Val Cys Val Leu Lys Gly Asp Gly Pro Val Gln
 1               5                  10                  15      
Gly Ile Ile Asn Phe Glu Gln Lys Glu Ser Asn Gly Pro Val Lys Val
            20                  25                  30          
Trp Gly Ser Ile Lys Gly Leu Thr Glu Gly Leu His Gly Phe His Val
        35                  40                  45              
His Glu Phe Gly Asp Asn Thr Ala Gly Cys Thr Ser Ala Gly Pro His
    50                  55                  60                  
Phe Asn Pro Leu Ser Arg Lys His Gly Gly Pro Lys Asp Glu Glu Arg
65                  70                  75                  80  
His Val Gly Asp Leu Gly Asn Val Thr Ala Asp Lys Asp Gly Val Ala
                85                  90                  95      
Asp Val Ser Ile Glu Gly Ser Val Ile Ser Leu Ser Gly Asp His Cys
            100                 105                 110         
Ile Ile Gly Arg Thr Leu Val Val His Glu Lys Ala Asp Asp Leu Gly
        115                 120                 125             
Lys Gly Gly Asn Glu Glu Ser Thr Lys Thr Gly Asn Ala Gly Ser Arg
    130                 135                 140                 
Leu Ala Cys Gly Val Ile Gly Ile Ala Gln
145                 150                 


<210> 186
<211> 55
<212> PRT
<213> Homo sapiens

<400> 186
Pro Arg Gln Glu Pro Pro Lys Ile His Leu Asp Cys Pro Gly Arg Ile
 1               5                  10                  15      
Pro Asp Thr Ile Val Val Val Ala Gly Asn Lys Leu Arg Leu Asp Val
            20                  25                  30          
Pro Ile Ser Gly Asp Pro Ala Pro Thr Val Ile Trp Gln Lys Ala Ile
        35                  40                  45              
Thr Gln Gly Asn Lys Ala Pro
    50                  55  


<210> 187
<211> 24
<212> PRT
<213> Homo sapiens

<400> 187
Leu Arg Arg Ser Ser Leu Lys Ala Tyr Gly Asn Gly Ala Ser Ser Asn
 1               5                  10                  15      
Gly Asn Thr Gly Glu Gln Ser Gly
            20                  


<210> 188
<211> 167
<212> PRT
<213> Homo sapiens

<400> 188
Met Asn Arg Pro Ala Pro Val Glu Ile Ser Tyr Glu Asp Met Arg Phe
 1               5                  10                  15      
Leu Ile Thr His Asn Pro Thr Asn Ala Thr Leu Asn Lys Phe Thr Glu
            20                  25                  30          
Glu Leu Lys Lys Tyr Gly Val Thr Thr Leu Val Arg Val Cys Asp Ala
        35                  40                  45              
Thr Tyr Asp Lys Ala Pro Val Glu Lys Glu Gly Ile His Val Leu Asp
    50                  55                  60                  
Trp Pro Phe Asp Asp Gly Ala Pro Pro Pro Asn Gln Ile Val Asp Asp
65                  70                  75                  80  
Trp Leu Asn Leu Leu Lys Thr Lys Phe Arg Glu Glu Pro Gly Cys Cys
                85                  90                  95      
Val Ala Val His Cys Val Ala Gly Leu Gly Arg Ala Pro Val Leu Val
            100                 105                 110         
Ala Leu Ala Leu Ile Glu Cys Gly Met Lys Tyr Glu Asp Ala Val Gln
        115                 120                 125             
Phe Ile Arg Gln Lys Arg Arg Gly Ala Phe Asn Ser Lys Gln Leu Leu
    130                 135                 140                 
Tyr Leu Glu Lys Tyr Arg Pro Lys Met Arg Leu Arg Phe Arg Asp Thr
145                 150                 155                 160 
Asn Gly His Cys Cys Val Gln
                165         


<210> 189
<211> 318
<212> PRT
<213> Homo sapiens

<400> 189
Met Pro Met Ala Asn Leu Leu Leu Leu Ile Val Pro Ile Leu Ile Ala
 1               5                  10                  15      
Met Ala Phe Leu Met Leu Thr Glu Arg Lys Ile Leu Gly Tyr Met Gln
            20                  25                  30          
Leu Arg Lys Gly Pro Asn Val Val Gly Pro Tyr Gly Leu Leu Gln Pro
        35                  40                  45              
Phe Ala Asp Ala Met Lys Leu Phe Thr Lys Glu Pro Leu Lys Pro Ala
    50                  55                  60                  
Thr Ser Thr Ile Thr Leu Tyr Ile Thr Ala Pro Thr Leu Ala Leu Thr
65                  70                  75                  80  
Ile Ala Leu Leu Leu Trp Ala Pro Leu Pro Met Pro Asn Pro Leu Val
                85                  90                  95      
Asn Leu Asn Leu Gly Leu Leu Phe Ile Leu Ala Thr Ser Ser Leu Ala
            100                 105                 110         
Val Tyr Ser Ile Leu Trp Ser Gly Trp Ala Ser Asn Ser Asn Tyr Ala
        115                 120                 125             
Leu Ile Gly Ala Leu Arg Ala Val Ala Gln Thr Ile Ser Tyr Glu Val
    130                 135                 140                 
Thr Leu Ala Ile Ile Leu Leu Ser Thr Leu Leu Met Ser Gly Ser Phe
145                 150                 155                 160 
Asn Leu Ser Thr Leu Ile Thr Ala Gln Glu His Leu Trp Leu Leu Leu
                165                 170                 175     
Pro Ser Trp Pro Leu Ala Met Met Trp Phe Ile Ser Thr Leu Ala Glu
            180                 185                 190         
Thr Asn Arg Thr Pro Phe Asp Leu Ala Glu Gly Glu Ser Glu Leu Val
        195                 200                 205             
Ser Gly Phe Asn Ile Glu Tyr Ala Ala Gly Pro Phe Ala Leu Phe Phe
    210                 215                 220                 
Met Ala Glu Tyr Thr Asn Ile Ile Met Met Asn Thr Leu Thr Thr Thr
225                 230                 235                 240 
Ile Phe Leu Gly Thr Thr Tyr Asp Ala Leu Ser Pro Glu Leu Tyr Thr
                245                 250                 255     
Thr Tyr Phe Val Thr Lys Thr Leu Leu Leu Thr Ser Leu Phe Leu Trp
            260                 265                 270         
Ile Arg Thr Ala Tyr Pro Arg Phe Arg Tyr Asp Gln Leu Met His Leu
        275                 280                 285             
Leu Trp Lys Asn Phe Leu Pro Leu Thr Leu Ala Leu Leu Met Trp Tyr
    290                 295                 300                 
Val Ser Met Pro Ile Thr Ile Ser Ser Ile Pro Pro Gln Thr
305                 310                 315             


<210> 190
<211> 347
<212> PRT
<213> Homo sapiens

<400> 190
Met Asn Pro Leu Ala Gln Pro Val Ile Tyr Ser Thr Ile Phe Ala Gly
 1               5                  10                  15      
Thr Leu Ile Thr Ala Leu Ser Ser His Trp Phe Phe Thr Trp Val Gly
            20                  25                  30          
Leu Glu Met Asn Met Leu Ala Phe Ile Pro Ile Leu Thr Lys Lys Met
        35                  40                  45              
Asn Pro Arg Ser Thr Glu Ala Ala Ile Lys Tyr Phe Leu Thr Gln Ala
    50                  55                  60                  
Thr Ala Ser Met Ile Leu Leu Met Ala Ile Leu Phe Asn Asn Met Leu
65                  70                  75                  80  
Ser Gly Gln Trp Thr Met Thr Asn Thr Thr Asn Gln Tyr Ser Ser Leu
                85                  90                  95      
Met Ile Met Met Ala Met Ala Met Lys Leu Gly Met Ala Pro Phe His
            100                 105                 110         
Phe Trp Val Pro Glu Val Thr Gln Gly Thr Pro Leu Thr Ser Gly Leu
        115                 120                 125             
Leu Leu Leu Thr Trp Gln Lys Leu Ala Pro Ile Ser Ile Met Tyr Gln
    130                 135                 140                 
Ile Ser Pro Ser Leu Asn Val Ser Leu Leu Leu Thr Leu Ser Ile Leu
145                 150                 155                 160 
Ser Ile Met Ala Gly Ser Trp Gly Gly Leu Asn Gln Thr Gln Leu Arg
                165                 170                 175     
Lys Ile Leu Ala Tyr Ser Ser Ile Thr His Met Gly Trp Met Met Ala
            180                 185                 190         
Val Leu Pro Tyr Asn Pro Asn Met Thr Ile Leu Asn Leu Thr Ile Tyr
        195                 200                 205             
Ile Ile Leu Thr Thr Thr Ala Phe Leu Leu Leu Asn Leu Asn Ser Ser
    210                 215                 220                 
Thr Thr Thr Leu Leu Leu Ser Arg Thr Trp Asn Lys Leu Thr Trp Leu
225                 230                 235                 240 
Thr Pro Leu Ile Pro Ser Thr Leu Leu Ser Leu Gly Gly Leu Pro Pro
                245                 250                 255     
Leu Thr Gly Phe Leu Pro Lys Trp Ala Ile Ile Glu Glu Phe Thr Lys
            260                 265                 270         
Asn Asn Ser Leu Ile Ile Pro Thr Ile Met Ala Thr Ile Thr Leu Leu
        275                 280                 285             
Asn Leu Tyr Phe Tyr Leu Arg Leu Ile Tyr Ser Thr Ser Ile Thr Leu
    290                 295                 300                 
Leu Pro Met Ser Asn Asn Val Lys Met Lys Trp Gln Phe Glu His Thr
305                 310                 315                 320 
Lys Pro Thr Pro Leu Leu Pro Thr Leu Ile Thr Leu Thr Thr Leu Leu
                325                 330                 335     
Leu Pro Ile Ser Pro Phe Met Leu Met Ile Leu
            340                 345         


<210> 191
<211> 513
<212> PRT
<213> Homo sapiens

<400> 191
Met Phe Ala Asp Arg Trp Leu Phe Ser Thr Asn His Lys Asp Ile Gly
 1               5                  10                  15      
Thr Leu Tyr Leu Leu Phe Gly Ala Trp Ala Gly Val Leu Gly Thr Ala
            20                  25                  30          
Leu Ser Leu Leu Ile Arg Ala Glu Leu Gly Gln Pro Gly Asn Leu Leu
        35                  40                  45              
Gly Asn Asp His Ile Tyr Asn Val Ile Val Thr Ala His Ala Phe Val
    50                  55                  60                  
Met Ile Phe Phe Met Val Met Pro Ile Met Ile Gly Gly Phe Gly Asn
65                  70                  75                  80  
Trp Leu Val Pro Leu Met Ile Gly Ala Pro Asp Met Ala Phe Pro Arg
                85                  90                  95      
Met Asn Asn Met Ser Phe Trp Leu Leu Pro Pro Ser Leu Leu Leu Leu
            100                 105                 110         
Leu Ala Ser Ala Met Val Glu Ala Gly Ala Gly Thr Gly Trp Thr Val
        115                 120                 125             
Tyr Pro Pro Leu Ala Gly Asn Tyr Ser His Pro Gly Ala Ser Val Asp
    130                 135                 140                 
Leu Thr Ile Phe Ser Leu His Leu Ala Gly Val Ser Ser Ile Leu Gly
145                 150                 155                 160 
Ala Ile Asn Phe Ile Thr Thr Ile Ile Asn Met Lys Pro Pro Ala Met
                165                 170                 175     
Thr Gln Tyr Gln Thr Pro Leu Phe Val Trp Ser Val Leu Ile Thr Ala
            180                 185                 190         
Val Leu Leu Leu Leu Ser Leu Pro Val Leu Ala Ala Gly Ile Thr Met
        195                 200                 205             
Leu Leu Thr Asp Arg Asn Leu Asn Thr Thr Phe Phe Asp Pro Ala Gly
    210                 215                 220                 
Gly Gly Asp Pro Ile Leu Tyr Gln His Leu Ser Trp Phe Phe Gly His
225                 230                 235                 240 
Pro Glu Val Tyr Ile Leu Ile Leu Pro Gly Phe Gly Met Ile Ser His
                245                 250                 255     
Ile Val Thr Tyr Tyr Ser Gly Lys Lys Glu Pro Phe Gly Tyr Met Gly
            260                 265                 270         
Met Val Trp Ala Met Met Ser Ile Gly Phe Leu Gly Phe Ile Val Trp
        275                 280                 285             
Ala His His Met Phe Thr Val Gly Met Asp Val Asp Thr Arg Ala Tyr
    290                 295                 300                 
Phe Thr Ser Ala Thr Met Ile Ile Ala Ile Pro Thr Gly Val Lys Val
305                 310                 315                 320 
Phe Ser Trp Leu Ala Thr Leu His Gly Ser Asn Met Lys Trp Ser Ala
                325                 330                 335     
Ala Val Leu Trp Ala Leu Gly Phe Ile Phe Leu Phe Thr Val Gly Gly
            340                 345                 350         
Leu Thr Gly Ile Val Leu Ala Asn Ser Ser Leu Asp Ile Val Leu His
        355                 360                 365             
Asp Thr Tyr Tyr Val Val Ala His Phe His Tyr Val Leu Ser Met Gly
    370                 375                 380                 
Ala Val Phe Ala Ile Met Gly Gly Phe Ile His Trp Phe Pro Leu Phe
385                 390                 395                 400 
Ser Gly Tyr Thr Leu Asp Gln Thr Tyr Ala Lys Ile His Phe Ala Ile
                405                 410                 415     
Met Phe Ile Gly Val Asn Leu Thr Phe Phe Pro Gln His Phe Leu Gly
            420                 425                 430         
Leu Ser Gly Met Pro Arg Arg Tyr Ser Asp Tyr Pro Asp Ala Tyr Thr
        435                 440                 445             
Thr Trp Asn Ile Leu Ser Ser Val Gly Ser Phe Ile Ser Leu Thr Ala
    450                 455                 460                 
Val Met Leu Met Ile Phe Met Ile Trp Glu Ala Phe Ala Ser Lys Arg
465                 470                 475                 480 
Lys Val Leu Met Val Glu Glu Pro Ser Met Asn Leu Glu Trp Leu Tyr
                485                 490                 495     
Gly Cys Pro Pro Pro Tyr His Thr Phe Glu Glu Pro Val Tyr Met Lys
            500                 505                 510         
Ser
    


<210> 192
<211> 226
<212> PRT
<213> Homo sapiens

<400> 192
Met Asn Glu Asn Leu Phe Ala Ser Phe Ile Ala Pro Thr Val Leu Gly
 1               5                  10                  15      
Leu Pro Ala Ala Val Leu Ile Ile Leu Phe Pro Pro Leu Leu Ile Pro
            20                  25                  30          
Thr Ser Lys Tyr Leu Ile Asn Asn Arg Leu Ile Thr Thr Gln Gln Trp
        35                  40                  45              
Leu Ile Lys Leu Thr Ser Lys Gln Met Met Ala Met His Asn Thr Lys
    50                  55                  60                  
Gly Arg Thr Trp Ser Leu Met Leu Val Ser Leu Ile Ile Phe Ile Ala
65                  70                  75                  80  
Thr Thr Asn Leu Leu Gly Leu Leu Pro His Ser Phe Thr Pro Thr Thr
                85                  90                  95      
Gln Leu Ser Met Asn Leu Ala Met Ala Ile Pro Leu Trp Ala Gly Ala
            100                 105                 110         
Val Ile Met Gly Phe Arg Ser Lys Ile Lys Asn Ala Leu Ala His Phe
        115                 120                 125             
Leu Pro Gln Gly Thr Pro Thr Pro Leu Ile Pro Met Leu Val Ile Ile
    130                 135                 140                 
Glu Thr Ile Ser Leu Leu Ile Gln Pro Met Ala Leu Ala Val Arg Leu
145                 150                 155                 160 
Thr Ala Asn Ile Thr Ala Gly His Leu Leu Met His Leu Ile Gly Ser
                165                 170                 175     
Ala Thr Leu Ala Met Ser Thr Ile Asn Leu Pro Ser Thr Leu Ile Ile
            180                 185                 190         
Phe Thr Ile Leu Ile Leu Leu Thr Ile Leu Glu Ile Ala Val Ala Leu
        195                 200                 205             
Ile Gln Ala Tyr Val Phe Thr Leu Leu Val Ser Leu Tyr Leu His Asp
    210                 215                 220                 
Asn Thr
225     


<210> 193
<211> 305
<212> PRT
<213> Homo sapiens

<400> 193
Val Ser Thr Ser Ser Met Gly Thr Leu Pro Lys Arg Val Lys Ile Val
 1               5                  10                  15      
Glu Val Gly Pro Gln Asp Gly Leu Gln Asn Glu Lys Asn Ile Val Ser
            20                  25                  30          
Thr Pro Val Lys Ile Lys Leu Ile Asp Met Leu Ser Glu Ala Gly Leu
        35                  40                  45              
Ser Val Ile Glu Thr Thr Ser Phe Val Ser Pro Lys Trp Val Pro Gln
    50                  55                  60                  
Met Gly Asp His Thr Glu Val Leu Lys Gly Ile Gln Lys Phe Pro Gly
65                  70                  75                  80  
Ile Asn Tyr Pro Val Leu Thr Pro Asn Leu Lys Gly Phe Glu Ala Ala
                85                  90                  95      
Val Ala Ala Gly Ala Lys Glu Val Val Ile Phe Gly Ala Ala Ser Glu
            100                 105                 110         
Leu Phe Thr Lys Lys Asn Ile Asn Cys Ser Ile Glu Glu Ser Phe Gln
        115                 120                 125             
Arg Phe Asp Ala Ile Leu Lys Ala Ala Gln Ser Ala Asn Ile Ser Val
    130                 135                 140                 
Arg Gly Tyr Val Ser Cys Ala Leu Gly Cys Pro Tyr Glu Gly Lys Ile
145                 150                 155                 160 
Ser Pro Ala Lys Val Ala Glu Val Thr Lys Lys Phe Tyr Ser Met Gly
                165                 170                 175     
Cys Tyr Glu Ile Ser Leu Gly Asp Thr Ile Gly Val Gly Thr Pro Gly
            180                 185                 190         
Ile Met Lys Asp Met Leu Ser Ala Val Met Gln Glu Val Pro Leu Ala
        195                 200                 205             
Ala Leu Ala Val His Cys His Asp Thr Tyr Gly Gln Ala Leu Ala Asn
    210                 215                 220                 
Thr Leu Met Ala Leu Gln Met Gly Val Ser Val Val Asp Ser Ser Val
225                 230                 235                 240 
Ala Gly Leu Gly Gly Cys Pro Tyr Ala Gln Gly Ala Ser Gly Asn Leu
                245                 250                 255     
Ala Thr Glu Asp Leu Val Tyr Met Leu Glu Gly Leu Gly Ile His Thr
            260                 265                 270         
Gly Val Asn Leu Gln Lys Leu Leu Glu Ala Gly Asn Phe Ile Cys Gln
        275                 280                 285             
Ala Leu Asn Arg Lys Thr Ser Ser Lys Val Ala Gln Ala Thr Cys Lys
    290                 295                 300                 
Leu
305 


<210> 194
<211> 536
<212> PRT
<213> Homo sapiens

<400> 194
Met His Asn Leu Gly His Lys Asn Asn Asn Pro Pro Lys Glu Pro Gln
 1               5                  10                  15      
Pro Lys Arg Val Glu Glu Val Tyr Arg Ala Leu Lys Asn Gly Leu Asp
            20                  25                  30          
Glu Tyr Leu Glu Val His Gln Thr Glu Leu Asp Lys Leu Thr Ala Gln
        35                  40                  45              
Leu Lys Asp Met Lys Arg Asn Ser Arg Leu Gly Val Leu Tyr Asp Leu
    50                  55                  60                  
Asp Lys Gln Ile Lys Thr Ile Glu Arg Tyr Met Arg Arg Leu Glu Phe
65                  70                  75                  80  
His Ile Ser Lys Val Asp Glu Leu Tyr Glu Ala Tyr Cys Ile Gln Arg
                85                  90                  95      
Arg Leu Gln Asp Gly Ala Ser Lys Met Lys Gln Ala Phe Ala Thr Ser
            100                 105                 110         
Pro Ala Ser Lys Ala Ala Arg Glu Ser Leu Thr Glu Ile Asn Arg Ser
        115                 120                 125             
Phe Lys Glu Tyr Thr Glu Asn Met Cys Thr Ile Glu Val Glu Leu Glu
    130                 135                 140                 
Asn Leu Leu Gly Glu Phe Ser Ile Lys Met Lys Gly Leu Ala Gly Phe
145                 150                 155                 160 
Ala Arg Leu Cys Pro Gly Asp Gln Tyr Glu Ile Phe Met Lys Tyr Gly
                165                 170                 175     
Arg Gln Arg Trp Lys Leu Lys Gly Lys Ile Glu Val Asn Gly Lys Gln
            180                 185                 190         
Ser Trp Asp Gly Glu Glu Thr Val Phe Leu Pro Leu Ile Val Gly Phe
        195                 200                 205             
Ile Ser Ile Lys Val Thr Glu Leu Lys Gly Leu Ala Thr His Ile Leu
    210                 215                 220                 
Val Gly Ser Val Thr Cys Glu Thr Lys Glu Leu Phe Ala Ala Arg Pro
225                 230                 235                 240 
Gln Val Val Ala Val Asp Ile Asn Asp Leu Gly Thr Ile Lys Leu Asn
                245                 250                 255     
Leu Glu Ile Thr Trp Tyr Pro Phe Asp Val Glu Asp Met Thr Ala Ser
            260                 265                 270         
Ser Gly Ala Gly Asn Lys Ala Ala Ala Leu Gln Arg Arg Met Ser Met
        275                 280                 285             
Tyr Ser Gln Gly Thr Pro Glu Thr Pro Thr Phe Lys Asp His Ser Phe
    290                 295                 300                 
Phe Ser Asn Leu Pro Asp Asp Ile Phe Glu Asn Gly Lys Ala Ala Glu
305                 310                 315                 320 
Glu Lys Met Pro Leu Ser Leu Ser Phe Ser Asp Leu Pro Thr Asp Cys
                325                 330                 335     
Ala Leu Thr Ser His Ser Thr Gly Ser Pro Ser Asn Ser Thr Asn Pro
            340                 345                 350         
Glu Ile Thr Ile Thr Pro Ala Glu Phe Asn Leu Ser Ser Leu Ala Ser
        355                 360                 365             
Gln Asn Glu Gly Met Asp Asp Thr Ser Ser Ala Ser Ser Arg Asn Ser
    370                 375                 380                 
Leu Gly Glu Gly Gln Glu Pro Lys Ser His Leu Lys Glu Glu Asp Pro
385                 390                 395                 400 
Glu Glu Pro Arg Lys Pro Ala Ser Ala Pro Ser Glu Ala Cys Arg Arg
                405                 410                 415     
Gln Ser Ser Gly Ala Gly Ala Glu His Leu Phe Leu Glu Asn Asp Val
            420                 425                 430         
Ala Glu Ala Leu Leu Gln Glu Ser Glu Glu Ala Ser Glu Leu Lys Pro
        435                 440                 445             
Val Glu Leu Asp Thr Ser Glu Gly Asn Ile Thr Lys Gln Leu Val Lys
    450                 455                 460                 
Arg Leu Thr Ser Ala Glu Val Pro Met Ala Thr Asp Arg Leu Leu Ser
465                 470                 475                 480 
Glu Gly Ser Val Gly Gly Glu Ser Glu Gly Cys Arg Ser Phe Leu Asp
                485                 490                 495     
Gly Ser Leu Glu Asp Ala Phe Asn Gly Leu Leu Leu Ala Leu Glu Pro
            500                 505                 510         
His Lys Glu Gln Tyr Lys Glu Phe Gln Asp Leu Asn Gln Glu Val Met
        515                 520                 525             
Asn Leu Asp Asp Ile Leu Lys Lys
    530                 535     


<210> 195
<211> 3002
<212> PRT
<213> Homo sapiens

<400> 195
Tyr Phe Ser Arg Glu Lys Pro Leu Arg Gly Arg Tyr Leu Lys Arg Trp
 1               5                  10                  15      
Gly Lys Glu Gly Ala Ala Gly Ala Ala Ala Glu Thr Val Gly Ala Thr
            20                  25                  30          
Ser Gly Gln Glu Pro Gln Leu Gly Gln Leu Arg Ala Glu Pro Ser Ser
        35                  40                  45              
Gly Cys Ser Gly His Asp Trp Glu Gln Pro Pro Pro Pro Pro Arg Glu
    50                  55                  60                  
Ser Glu Pro Pro Leu Leu His Trp Gln Gly Pro Pro Glu Val Gly Ala
65                  70                  75                  80  
Ala Pro Gly Glu Gly Gly Arg Ser Pro Ala Arg Gly Thr Gly Gly Gly
                85                  90                  95      
Ile Ala Gly Pro Arg Arg Arg Gly Ala Leu Gln Gly Ala Ala Ala Ala
            100                 105                 110         
Ala Asp Arg Ala Pro Gly Ala Ala Arg Gly Gly Gly Ser Arg Trp Arg
        115                 120                 125             
Leu Gly Ile Met Arg Arg Gly Arg Leu Leu Glu Ile Ala Leu Gly Phe
    130                 135                 140                 
Thr Val Leu Leu Ala Ser Tyr Thr Ser His Gly Ala Asp Ala Asn Leu
145                 150                 155                 160 
Glu Ala Gly Asn Val Lys Glu Thr Arg Ala Ser Arg Ala Lys Arg Arg
                165                 170                 175     
Gly Gly Gly Gly His Asp Ala Leu Lys Gly Pro Asn Val Cys Gly Ser
            180                 185                 190         
Arg Tyr Asn Ala Tyr Cys Cys Pro Gly Trp Lys Thr Leu Pro Gly Gly
        195                 200                 205             
Asn Gln Cys Ile Val Pro Ile Cys Arg His Ser Cys Gly Asp Gly Phe
    210                 215                 220                 
Cys Ser Arg Pro Asn Met Cys Thr Cys Pro Ser Gly Gln Ile Ala Pro
225                 230                 235                 240 
Ser Cys Gly Ser Arg Ser Ile Gln His Cys Asn Ile Arg Cys Met Asn
                245                 250                 255     
Gly Gly Ser Cys Ser Asp Asp His Cys Leu Cys Gln Lys Gly Tyr Ile
            260                 265                 270         
Gly Thr His Cys Gly Gln Pro Val Cys Glu Ser Gly Cys Leu Asn Gly
        275                 280                 285             
Gly Arg Cys Val Ala Pro Asn Arg Cys Ala Cys Thr Tyr Gly Phe Thr
    290                 295                 300                 
Gly Pro Gln Cys Glu Arg Asp Tyr Arg Thr Gly Pro Cys Phe Thr Val
305                 310                 315                 320 
Ile Ser Asn Gln Met Cys Gln Gly Gln Leu Ser Gly Ile Val Cys Thr
                325                 330                 335     
Lys Thr Leu Cys Cys Ala Thr Val Gly Arg Ala Trp Gly His Pro Cys
            340                 345                 350         
Glu Met Cys Pro Ala Gln Pro His Pro Cys Arg Arg Gly Phe Ile Pro
        355                 360                 365             
Asn Ile Arg Thr Gly Ala Cys Gln Asp Val Asp Glu Cys Gln Ala Ile
    370                 375                 380                 
Pro Gly Leu Cys Gln Gly Gly Asn Cys Ile Asn Thr Val Gly Ser Phe
385                 390                 395                 400 
Glu Cys Lys Cys Pro Ala Gly His Lys Leu Asn Glu Val Ser Gln Lys
                405                 410                 415     
Cys Glu Asp Ile Asp Glu Cys Ser Thr Ile Pro Gly Ile Cys Glu Gly
            420                 425                 430         
Gly Glu Cys Thr Asn Thr Val Ser Ser Tyr Phe Cys Lys Cys Pro Pro
        435                 440                 445             
Gly Phe Tyr Thr Ser Pro Asp Gly Thr Arg Cys Ile Asp Val Arg Pro
    450                 455                 460                 
Gly Tyr Cys Tyr Thr Ala Leu Thr Asn Gly Arg Cys Ser Asn Gln Leu
465                 470                 475                 480 
Pro Gln Ser Ile Thr Lys Met Gln Cys Cys Cys Asp Ala Gly Arg Cys
                485                 490                 495     
Trp Ser Pro Gly Val Thr Val Ala Pro Glu Met Cys Pro Ile Arg Ala
            500                 505                 510         
Thr Glu Asp Phe Asn Lys Leu Cys Ser Val Pro Met Val Ile Pro Gly
        515                 520                 525             
Arg Pro Glu Tyr Pro Pro Pro Pro Leu Gly Pro Ile Pro Pro Val Leu
    530                 535                 540                 
Pro Val Pro Pro Gly Phe Pro Pro Gly Pro Gln Ile Pro Val Pro Arg
545                 550                 555                 560 
Pro Pro Val Glu Tyr Leu Tyr Pro Ser Arg Glu Pro Pro Arg Val Leu
                565                 570                 575     
Pro Val Asn Val Thr Asp Tyr Cys Gln Leu Val Arg Tyr Leu Cys Gln
            580                 585                 590         
Asn Gly Arg Cys Ile Pro Thr Pro Gly Ser Tyr Arg Cys Glu Cys Asn
        595                 600                 605             
Lys Gly Phe Gln Leu Asp Leu Arg Gly Glu Cys Ile Asp Val Asp Glu
    610                 615                 620                 
Cys Glu Lys Asn Pro Cys Ala Gly Gly Glu Cys Ile Asn Asn Gln Gly
625                 630                 635                 640 
Ser Tyr Thr Cys Gln Cys Arg Ala Gly Tyr Gln Ser Thr Leu Thr Arg
                645                 650                 655     
Thr Glu Cys Arg Asp Ile Asp Glu Cys Leu Gln Asn Gly Arg Ile Cys
            660                 665                 670         
Asn Asn Gly Arg Cys Ile Asn Thr Asp Gly Ser Phe His Cys Val Cys
        675                 680                 685             
Asn Ala Gly Phe His Val Thr Arg Asp Gly Lys Asn Cys Glu Asp Met
    690                 695                 700                 
Asp Glu Cys Ser Ile Arg Asn Met Cys Leu Asn Gly Met Cys Ile Asn
705                 710                 715                 720 
Glu Asp Gly Ser Phe Lys Cys Ile Cys Lys Pro Gly Phe Gln Leu Ala
                725                 730                 735     
Ser Asp Gly Arg Tyr Cys Lys Asp Ile Asn Glu Cys Glu Thr Pro Gly
            740                 745                 750         
Ile Cys Met Asn Gly Arg Cys Val Asn Thr Asp Gly Ser Tyr Arg Cys
        755                 760                 765             
Glu Cys Phe Pro Gly Leu Ala Val Gly Leu Asp Gly Arg Val Cys Val
    770                 775                 780                 
Asp Thr His Met Arg Ser Thr Cys Tyr Gly Gly Tyr Lys Arg Gly Gln
785                 790                 795                 800 
Cys Ile Lys Pro Leu Phe Gly Ala Val Thr Lys Ser Glu Cys Cys Cys
                805                 810                 815     
Ala Ser Thr Glu Tyr Ala Phe Gly Glu Pro Cys Gln Pro Cys Pro Ala
            820                 825                 830         
Gln Asn Ser Ala Glu Tyr Gln Ala Leu Cys Ser Ser Gly Pro Gly Met
        835                 840                 845             
Thr Ser Ala Gly Ser Asp Ile Asn Glu Cys Ala Leu Asp Pro Asp Ile
    850                 855                 860                 
Cys Pro Asn Gly Ile Cys Glu Asn Leu Arg Gly Thr Tyr Lys Cys Ile
865                 870                 875                 880 
Cys Asn Ser Gly Tyr Glu Val Asp Ser Thr Gly Lys Asn Cys Val Asp
                885                 890                 895     
Ile Asn Glu Cys Val Leu Asn Ser Leu Leu Cys Asp Asn Gly Gln Cys
            900                 905                 910         
Arg Asn Thr Pro Gly Ser Phe Val Cys Thr Cys Pro Lys Gly Phe Ile
        915                 920                 925             
Tyr Lys Pro Asp Leu Lys Thr Cys Glu Asp Ile Asp Glu Cys Glu Ser
    930                 935                 940                 
Ser Pro Cys Ile Asn Gly Val Cys Lys Asn Ser Pro Gly Ser Phe Ile
945                 950                 955                 960 
Cys Glu Cys Ser Ser Glu Ser Thr Leu Asp Pro Thr Lys Thr Ile Cys
                965                 970                 975     
Ile Glu Thr Ile Lys Gly Thr Cys Trp Gln Thr Val Ile Asp Gly Arg
            980                 985                 990         
Cys Glu Ile Asn Ile Asn Gly Ala Thr Leu Lys Ser Gln Cys Cys Ser
        995                 1000                1005            
Ser Leu Gly Ala Ala Trp Gly Ser Pro Cys Thr Leu Cys Gln Val Asp
    1010                1015                1020                
Pro Ile Cys Gly Lys Gly Tyr Ser Arg Ile Lys Gly Thr Gln Cys Glu
1025                1030                1035                1040
Asp Ile Asp Glu Cys Glu Val Phe Pro Gly Val Cys Lys Asn Gly Leu
                1045                1050                1055    
Cys Val Asn Thr Arg Gly Ser Phe Lys Cys Gln Cys Pro Ser Gly Met
            1060                1065                1070        
Thr Leu Asp Ala Thr Gly Arg Ile Cys Leu Asp Ile Arg Leu Glu Thr
        1075                1080                1085            
Cys Phe Leu Arg Tyr Glu Asp Glu Glu Cys Thr Leu Pro Ile Ala Gly
    1090                1095                1100                
Arg His Arg Met Asp Ala Cys Cys Cys Ser Val Gly Ala Ala Trp Gly
1105                1110                1115                1120
Thr Glu Glu Cys Glu Glu Cys Pro Met Arg Asn Thr Pro Glu Tyr Glu
                1125                1130                1135    
Glu Leu Cys Pro Arg Gly Pro Gly Phe Ala Thr Lys Glu Ile Thr Asn
            1140                1145                1150        
Gly Lys Pro Phe Phe Lys Asp Ile Asn Glu Cys Lys Met Ile Pro Ser
        1155                1160                1165            
Leu Cys Thr His Gly Lys Cys Arg Asn Thr Ile Gly Ser Phe Lys Cys
    1170                1175                1180                
Arg Cys Asp Ser Gly Phe Ala Leu Asp Ser Glu Glu Arg Asn Cys Thr
1185                1190                1195                1200
Asp Ile Asp Glu Cys Arg Ile Ser Pro Asp Leu Cys Gly Arg Gly Gln
                1205                1210                1215    
Cys Val Asn Thr Pro Gly Asp Phe Glu Cys Lys Cys Asp Glu Gly Tyr
            1220                1225                1230        
Glu Ser Gly Phe Met Met Met Lys Asn Cys Met Asp Ile Asp Glu Cys
        1235                1240                1245            
Gln Arg Asp Pro Leu Leu Cys Arg Gly Gly Val Cys His Asn Thr Glu
    1250                1255                1260                
Gly Ser Tyr Arg Cys Glu Cys Pro Pro Gly His Gln Leu Ser Pro Asn
1265                1270                1275                1280
Ile Ser Ala Cys Ile Asp Ile Asn Glu Cys Glu Leu Ser Ala His Leu
                1285                1290                1295    
Cys Pro Asn Gly Arg Cys Val Asn Leu Ile Gly Lys Tyr Gln Cys Ala
            1300                1305                1310        
Cys Asn Pro Gly Tyr His Ser Thr Pro Asp Arg Leu Phe Cys Val Asp
        1315                1320                1325            
Ile Asp Glu Cys Ser Ile Met Asn Gly Gly Cys Glu Thr Phe Cys Thr
    1330                1335                1340                
Asn Ser Glu Gly Ser Tyr Glu Cys Ser Cys Gln Pro Gly Phe Ala Leu
1345                1350                1355                1360
Met Pro Asp Gln Arg Ser Cys Thr Asp Ile Asp Glu Cys Glu Asp Asn
                1365                1370                1375    
Pro Asn Ile Cys Asp Gly Gly Gln Cys Thr Asn Ile Pro Gly Glu Tyr
            1380                1385                1390        
Arg Cys Leu Cys Tyr Asp Gly Phe Met Ala Ser Glu Asp Met Lys Thr
        1395                1400                1405            
Cys Val Asp Val Asn Glu Cys Asp Leu Asn Pro Asn Ile Cys Leu Ser
    1410                1415                1420                
Gly Thr Cys Glu Asn Thr Lys Gly Ser Phe Ile Cys His Cys Asp Met
1425                1430                1435                1440
Gly Tyr Ser Gly Lys Lys Gly Lys Thr Gly Cys Thr Asp Ile Asn Glu
                1445                1450                1455    
Cys Glu Ile Gly Ala His Asn Cys Gly Lys His Ala Val Cys Thr Asn
            1460                1465                1470        
Thr Ala Gly Ser Phe Lys Cys Ser Cys Ser Pro Gly Trp Ile Gly Asp
        1475                1480                1485            
Gly Ile Lys Cys Thr Asp Leu Asp Glu Cys Ser Asn Gly Thr His Met
    1490                1495                1500                
Cys Ser Gln His Ala Asp Cys Lys Asn Thr Met Gly Ser Tyr Arg Cys
1505                1510                1515                1520
Leu Cys Lys Glu Gly Tyr Thr Gly Asp Gly Phe Thr Cys Thr Asp Leu
                1525                1530                1535    
Asp Glu Cys Ser Glu Asn Leu Asn Leu Cys Gly Asn Gly Gln Cys Leu
            1540                1545                1550        
Asn Ala Pro Gly Gly Tyr Arg Cys Glu Cys Asp Met Gly Phe Val Pro
        1555                1560                1565            
Ser Ala Asp Gly Lys Ala Cys Glu Asp Ile Asp Glu Cys Ser Leu Pro
    1570                1575                1580                
Asn Ile Cys Val Phe Gly Thr Cys His Asn Leu Pro Gly Leu Phe Arg
1585                1590                1595                1600
Cys Glu Cys Glu Ile Gly Tyr Glu Leu Asp Arg Ser Gly Gly Asn Cys
                1605                1610                1615    
Thr Asp Val Asn Glu Cys Leu Asp Pro Thr Thr Cys Ile Ser Gly Asn
            1620                1625                1630        
Cys Val Asn Thr Pro Gly Ser Tyr Ile Cys Asp Cys Pro Pro Asp Phe
        1635                1640                1645            
Glu Leu Asn Pro Thr Arg Val Gly Cys Val Asp Thr Arg Ser Gly Asn
    1650                1655                1660                
Cys Tyr Leu Asp Ile Arg Pro Arg Gly Asp Asn Gly Asp Thr Ala Cys
1665                1670                1675                1680
Ser Asn Glu Ile Gly Val Gly Val Ser Lys Ala Ser Cys Cys Cys Ser
                1685                1690                1695    
Leu Gly Lys Ala Trp Gly Thr Pro Cys Glu Met Cys Pro Ala Val Asn
            1700                1705                1710        
Thr Ser Glu Tyr Lys Ile Leu Cys Pro Gly Gly Glu Gly Phe Arg Pro
        1715                1720                1725            
Asn Pro Ile Thr Val Ile Leu Glu Asp Ile Asp Glu Cys Gln Glu Leu
    1730                1735                1740                
Pro Gly Leu Cys Gln Gly Gly Lys Cys Ile Asn Thr Phe Gly Ser Phe
1745                1750                1755                1760
Gln Cys Arg Cys Pro Thr Gly Tyr Tyr Leu Asn Glu Asp Thr Arg Val
                1765                1770                1775    
Cys Asp Asp Val Asn Glu Cys Glu Thr Pro Gly Ile Cys Gly Pro Gly
            1780                1785                1790        
Thr Cys Tyr Asn Thr Val Gly Asn Tyr Thr Cys Ile Cys Pro Pro Asp
        1795                1800                1805            
Tyr Met Gln Val Asn Gly Gly Asn Asn Cys Met Asp Met Arg Arg Ser
    1810                1815                1820                
Leu Cys Tyr Arg Asn Tyr Tyr Ala Asp Asn Gln Thr Cys Asp Gly Glu
1825                1830                1835                1840
Leu Leu Phe Asn Met Thr Lys Lys Met Cys Cys Cys Ser Tyr Asn Ile
                1845                1850                1855    
Gly Arg Ala Trp Asn Lys Pro Cys Glu Gln Cys Pro Ile Pro Ser Thr
            1860                1865                1870        
Asp Glu Phe Ala Thr Leu Cys Gly Ser Gln Arg Pro Gly Phe Val Ile
        1875                1880                1885            
Asp Ile Tyr Thr Gly Leu Pro Val Asp Ile Asp Glu Cys Arg Glu Ile
    1890                1895                1900                
Pro Gly Val Cys Glu Asn Gly Val Cys Ile Asn Met Val Gly Ser Phe
1905                1910                1915                1920
Arg Cys Glu Cys Pro Val Gly Phe Phe Tyr Asn Asp Lys Leu Leu Val
                1925                1930                1935    
Cys Glu Asp Ile Asp Glu Cys Gln Asn Gly Pro Val Cys Gln Arg Asn
            1940                1945                1950        
Ala Glu Cys Ile Asn Thr Ala Gly Ser Tyr Arg Cys Asp Cys Lys Pro
        1955                1960                1965            
Gly Tyr Arg Phe Thr Ser Thr Gly Gln Cys Asn Asp Arg Asn Glu Cys
    1970                1975                1980                
Gln Glu Ile Pro Asn Ile Cys Ser His Gly Gln Cys Ile Asp Thr Val
1985                1990                1995                2000
Gly Ser Phe Tyr Cys Leu Cys His Thr Gly Phe Lys Thr Asn Asp Asp
                2005                2010                2015    
Gln Thr Met Cys Leu Asp Ile Asn Glu Cys Glu Arg Asp Ala Cys Gly
            2020                2025                2030        
Asn Gly Thr Cys Arg Asn Thr Ile Gly Ser Phe Asn Cys Arg Cys Asn
        2035                2040                2045            
His Gly Phe Ile Leu Ser His Asn Asn Asp Cys Ile Asp Val Asp Glu
    2050                2055                2060                
Cys Ala Ser Gly Asn Gly Asn Leu Cys Arg Asn Gly Gln Cys Ile Asn
2065                2070                2075                2080
Thr Val Gly Ser Phe Gln Cys Gln Cys Asn Glu Gly Tyr Glu Val Ala
                2085                2090                2095    
Pro Asp Gly Arg Thr Cys Val Asp Ile Asn Glu Cys Leu Leu Glu Pro
            2100                2105                2110        
Arg Lys Cys Ala Pro Gly Thr Cys Gln Asn Leu Asp Gly Ser Tyr Arg
        2115                2120                2125            
Cys Ile Cys Pro Pro Gly Tyr Ser Leu Gln Asn Glu Lys Cys Glu Asp
    2130                2135                2140                
Ile Asp Glu Cys Val Glu Glu Pro Glu Ile Cys Ala Leu Gly Thr Cys
2145                2150                2155                2160
Ser Asn Thr Glu Gly Ser Phe Lys Cys Leu Cys Pro Glu Gly Phe Ser
                2165                2170                2175    
Leu Ser Ser Ser Gly Arg Arg Cys Gln Asp Leu Arg Met Ser Tyr Cys
            2180                2185                2190        
Tyr Ala Lys Phe Glu Gly Gly Lys Cys Ser Ser Pro Lys Ser Arg Asn
        2195                2200                2205            
His Ser Lys Gln Glu Cys Cys Cys Ala Leu Lys Gly Glu Gly Trp Gly
    2210                2215                2220                
Asp Pro Cys Glu Leu Cys Pro Thr Glu Pro Asp Glu Ala Phe Arg Gln
2225                2230                2235                2240
Ile Cys Pro Tyr Gly Ser Gly Ile Ile Val Gly Pro Asp Asp Ser Ala
                2245                2250                2255    
Val Asp Met Asp Glu Cys Lys Glu Pro Asp Val Cys Lys His Gly Gln
            2260                2265                2270        
Cys Ile Asn Thr Asp Gly Ser Tyr Arg Cys Glu Cys Pro Phe Gly Tyr
        2275                2280                2285            
Thr Leu Ala Gly Asn Glu Cys Val Asp Thr Asp Glu Cys Ser Val Gly
    2290                2295                2300                
Asn Pro Cys Gly Asn Gly Thr Cys Lys Asn Val Ile Gly Gly Phe Glu
2305                2310                2315                2320
Cys Thr Cys Glu Glu Gly Phe Glu Pro Gly Pro Met Met Thr Cys Glu
                2325                2330                2335    
Asp Ile Asn Glu Cys Ala Gln Asn Pro Leu Leu Cys Ala Phe Arg Cys
            2340                2345                2350        
Val Asn Thr Tyr Gly Ser Tyr Glu Cys Lys Cys Pro Val Gly Tyr Val
        2355                2360                2365            
Leu Arg Glu Asp Arg Arg Met Cys Lys Asp Glu Asp Glu Cys Glu Glu
    2370                2375                2380                
Gly Lys His Asp Cys Thr Glu Lys Gln Met Glu Cys Lys Asn Leu Ile
2385                2390                2395                2400
Gly Thr Tyr Met Cys Ile Cys Gly Pro Gly Tyr Gln Arg Arg Pro Asp
                2405                2410                2415    
Gly Glu Gly Cys Val Asp Glu Asn Glu Cys Gln Thr Lys Pro Gly Ile
            2420                2425                2430        
Cys Glu Asn Gly Arg Cys Leu Asn Thr Arg Gly Ser Tyr Thr Cys Glu
        2435                2440                2445            
Cys Asn Asp Gly Phe Thr Ala Ser Pro Asn Gln Asp Glu Cys Leu Asp
    2450                2455                2460                
Asn Arg Glu Gly Tyr Cys Phe Thr Glu Val Leu Gln Asn Met Cys Gln
2465                2470                2475                2480
Ile Gly Ser Ser Asn Arg Asn Pro Val Thr Lys Ser Glu Cys Cys Cys
                2485                2490                2495    
Asp Gly Gly Arg Gly Trp Gly Pro His Cys Glu Ile Cys Pro Phe Gln
            2500                2505                2510        
Gly Thr Val Ala Phe Lys Lys Leu Cys Pro His Gly Arg Gly Phe Met
        2515                2520                2525            
Thr Asn Gly Ala Asp Ile Asp Glu Cys Lys Val Ile His Asp Val Cys
    2530                2535                2540                
Arg Asn Gly Glu Cys Val Asn Asp Arg Gly Ser Tyr His Cys Ile Cys
2545                2550                2555                2560
Lys Thr Gly Tyr Thr Pro Asp Ile Thr Gly Thr Ser Cys Val Asp Leu
                2565                2570                2575    
Asn Glu Cys Asn Gln Ala Pro Lys Pro Cys Asn Phe Ile Cys Lys Asn
            2580                2585                2590        
Thr Glu Gly Ser Tyr Gln Cys Ser Cys Pro Lys Gly Tyr Ile Leu Gln
        2595                2600                2605            
Glu Asp Gly Arg Ser Cys Lys Asp Leu Asp Glu Cys Ala Thr Lys Gln
    2610                2615                2620                
His Asn Cys Gln Phe Leu Cys Val Asn Thr Ile Gly Gly Phe Thr Cys
2625                2630                2635                2640
Lys Cys Pro Pro Gly Phe Thr Gln His His Thr Ser Cys Ile Asp Asn
                2645                2650                2655    
Asn Glu Cys Thr Ser Asp Ile Asn Leu Cys Gly Ser Lys Gly Ile Cys
            2660                2665                2670        
Gln Asn Thr Pro Gly Ser Phe Thr Cys Glu Cys Gln Arg Gly Phe Ser
        2675                2680                2685            
Leu Asp Gln Thr Gly Ser Ser Cys Glu Asp Val Asp Glu Cys Glu Gly
    2690                2695                2700                
Asn His Arg Cys Gln His Gly Cys Gln Asn Ile Ile Gly Gly Tyr Arg
2705                2710                2715                2720
Cys Ser Cys Pro Gln Gly Tyr Leu Gln His Tyr Gln Trp Asn Gln Cys
                2725                2730                2735    
Val Asp Glu Asn Glu Cys Leu Ser Ala His Ile Cys Gly Gly Ala Ser
            2740                2745                2750        
Cys His Asn Thr Leu Gly Ser Tyr Lys Cys Met Cys Pro Ala Gly Phe
        2755                2760                2765            
Gln Tyr Glu Gln Phe Ser Gly Gly Cys Gln Asp Ile Asn Glu Cys Gly
    2770                2775                2780                
Ser Ala Gln Ala Pro Cys Ser Tyr Gly Cys Ser Asn Thr Glu Gly Gly
2785                2790                2795                2800
Tyr Leu Cys Gly Cys Pro Pro Gly Tyr Phe Arg Ile Gly Gln Gly His
                2805                2810                2815    
Cys Val Ser Gly Met Gly Met Gly Arg Gly Asn Pro Glu Pro Pro Val
            2820                2825                2830        
Ser Gly Glu Met Asp Asp Asn Ser Leu Ser Pro Glu Ala Cys Tyr Glu
        2835                2840                2845            
Cys Lys Ile Asn Gly Tyr Pro Lys Arg Gly Arg Lys Arg Arg Ser Thr
    2850                2855                2860                
Asn Glu Thr Asp Ala Ser Asn Ile Glu Asp Gln Ser Glu Thr Glu Ala
2865                2870                2875                2880
Asn Val Ser Leu Ala Ser Trp Asp Val Glu Lys Thr Ala Ile Phe Ala
                2885                2890                2895    
Phe Asn Ile Ser His Val Ser Asn Lys Val Arg Ile Leu Glu Leu Leu
            2900                2905                2910        
Pro Ala Leu Thr Thr Leu Thr Asn His Asn Arg Tyr Leu Ile Glu Ser
        2915                2920                2925            
Gly Asn Glu Asp Gly Phe Phe Lys Ile Asn Gln Lys Glu Gly Ile Ser
    2930                2935                2940                
Tyr Leu His Phe Thr Lys Lys Lys Pro Val Ala Gly Thr Tyr Ser Leu
2945                2950                2955                2960
Gln Ile Ser Ser Thr Pro Leu Tyr Lys Lys Lys Glu Leu Asn Gln Leu
                2965                2970                2975    
Glu Asp Lys Tyr Asp Lys Asp Tyr Leu Ser Gly Glu Leu Gly Asp Asn
            2980                2985                2990        
Leu Lys Met Lys Ile Gln Val Leu Leu His
        2995                3000        


<210> 196
<211> 34
<212> PRT
<213> Homo sapiens

<400> 196
Gln Leu Gly Pro Gln Gly Pro Pro His Leu Val Ala Asp Pro Ser Lys
 1               5                  10                  15      
Lys Gln Gly Pro Trp Leu Glu Glu Glu Glu Glu Ala Tyr Gly Trp Met
            20                  25                  30          
Asp Phe
        


<210> 197
<211> 238
<212> PRT
<213> Homo sapiens

<400> 197
Ile Val Gly Gly Arg Arg Ala Arg Pro His Ala Trp Pro Phe Met Val
 1               5                  10                  15      
Ser Leu Gln Leu Arg Gly Gly His Phe Cys Gly Ala Thr Leu Ile Ala
            20                  25                  30          
Pro Asn Phe Val Met Ser Ala Ala His Cys Val Ala Asn Val Asn Val
        35                  40                  45              
Arg Ala Val Arg Val Val Leu Gly Ala His Asn Leu Ser Arg Arg Glu
    50                  55                  60                  
Pro Thr Arg Gln Val Phe Ala Val Gln Arg Ile Phe Glu Asn Gly Tyr
65                  70                  75                  80  
Asp Pro Val Asn Leu Leu Asn Asp Ile Val Ile Leu Gln Leu Asn Gly
                85                  90                  95      
Ser Ala Thr Ile Asn Ala Asn Val Gln Val Ala Gln Leu Pro Ala Gln
            100                 105                 110         
Gly Arg Arg Leu Gly Asn Gly Val Gln Cys Leu Ala Met Gly Trp Gly
        115                 120                 125             
Leu Leu Gly Arg Asn Arg Gly Ile Ala Ser Val Leu Gln Glu Leu Asn
    130                 135                 140                 
Val Thr Val Val Thr Ser Leu Cys Arg Arg Ser Asn Val Cys Thr Leu
145                 150                 155                 160 
Val Arg Gly Arg Gln Ala Gly Val Cys Phe Gly Asp Ser Gly Ser Pro
                165                 170                 175     
Leu Val Cys Asn Gly Leu Ile His Gly Ile Ala Ser Phe Val Arg Gly
            180                 185                 190         
Gly Cys Ala Ser Gly Leu Tyr Pro Asp Ala Phe Ala Pro Val Ala Gln
        195                 200                 205             
Phe Val Asn Trp Ile Asp Ser Ile Ile Gln Arg Ser Glu Asp Asn Pro
    210                 215                 220                 
Cys Pro His Pro Arg Asp Pro Asp Pro Ala Ser Arg Thr His
225                 230                 235             


<210> 198
<211> 617
<212> PRT
<213> Homo sapiens

<400> 198
Val Leu Leu Trp Ser Ala Asn Lys Val Phe Glu Glu Leu Thr Asp Ile
 1               5                  10                  15      
Glu Arg Gln Phe His Lys Ala Phe Tyr Thr Val Arg Ala Tyr Leu Asn
            20                  25                  30          
Cys Glu Arg Tyr Ser Val Gly Leu Leu Asp Met Thr Lys Glu Lys Glu
        35                  40                  45              
Phe Phe Asp Val Trp Ser Val Leu Met Gly Glu Ser Gln Pro Tyr Ser
    50                  55                  60                  
Gly Pro Arg Thr Pro Asp Gly Arg Glu Ile Val Phe Tyr Lys Val Ile
65                  70                  75                  80  
Asp Tyr Ile Leu His Gly Lys Glu Glu Ile Lys Val Ile Pro Thr Pro
                85                  90                  95      
Ser Ala Asp His Trp Ala Leu Ala Ser Gly Leu Pro Ser Tyr Val Ala
            100                 105                 110         
Glu Ser Gly Phe Ile Cys Asn Ile Met Asn Ala Ser Ala Asp Glu Met
        115                 120                 125             
Phe Lys Phe Gln Glu Gly Ala Leu Asp Asp Ser Gly Trp Leu Ile Lys
    130                 135                 140                 
Asn Val Leu Ser Met Pro Ile Val Asn Lys Lys Glu Glu Ile Val Gly
145                 150                 155                 160 
Val Ala Thr Phe Tyr Asn Arg Lys Asp Gly Lys Pro Phe Asp Glu Gln
                165                 170                 175     
Asp Glu Val Leu Met Glu Ser Leu Thr Gln Phe Leu Gly Trp Ser Val
            180                 185                 190         
Met Asn Thr Asp Thr Tyr Asp Lys Met Asn Lys Leu Glu Asn Arg Lys
        195                 200                 205             
Asp Ile Ala Gln Asp Met Val Leu Tyr His Val Lys Cys Asp Arg Asp
    210                 215                 220                 
Glu Ile Gln Leu Ile Leu Pro Thr Arg Ala Arg Leu Gly Lys Glu Pro
225                 230                 235                 240 
Ala Asp Cys Asp Glu Asp Glu Leu Gly Glu Ile Leu Lys Glu Glu Leu
                245                 250                 255     
Pro Gly Pro Thr Thr Phe Asp Ile Tyr Glu Phe His Phe Ser Asp Leu
            260                 265                 270         
Glu Cys Thr Glu Leu Asp Leu Val Lys Cys Gly Ile Gln Met Tyr Tyr
        275                 280                 285             
Glu Leu Gly Val Val Arg Lys Phe Gln Ile Pro Gln Glu Val Leu Val
    290                 295                 300                 
Arg Phe Leu Phe Ser Ile Ser Lys Gly Tyr Arg Arg Ile Thr Tyr His
305                 310                 315                 320 
Asn Trp Arg His Gly Phe Asn Val Ala Gln Thr Met Phe Thr Leu Leu
                325                 330                 335     
Met Thr Gly Lys Leu Lys Ser Tyr Tyr Thr Asp Leu Glu Ala Phe Ala
            340                 345                 350         
Met Val Thr Ala Gly Leu Cys His Asp Ile Asp His Arg Gly Thr Asn
        355                 360                 365             
Asn Leu Tyr Gln Met Lys Ser Gln Asn Pro Leu Ala Lys Leu His Gly
    370                 375                 380                 
Ser Ser Ile Leu Glu Arg His His Leu Glu Phe Gly Lys Phe Leu Leu
385                 390                 395                 400 
Ser Glu Glu Thr Leu Asn Ile Tyr Gln Asn Leu Asn Arg Arg Gln His
                405                 410                 415     
Glu His Val Ile His Leu Met Asp Ile Ala Ile Ile Ala Thr Asp Leu
            420                 425                 430         
Ala Leu Tyr Phe Lys Lys Arg Ala Met Phe Gln Lys Ile Val Asp Glu
        435                 440                 445             
Ser Lys Asn Tyr Gln Asp Lys Lys Ser Trp Val Glu Tyr Leu Ser Leu
    450                 455                 460                 
Glu Thr Thr Arg Lys Glu Ile Val Met Ala Met Met Met Thr Ala Cys
465                 470                 475                 480 
Asp Leu Ser Ala Ile Thr Lys Pro Trp Glu Val Gln Ser Lys Val Ala
                485                 490                 495     
Leu Leu Val Ala Ala Glu Phe Trp Glu Gln Gly Asp Leu Glu Arg Thr
            500                 505                 510         
Val Leu Asp Gln Gln Pro Ile Pro Met Met Asp Arg Asn Lys Ala Ala
        515                 520                 525             
Glu Leu Pro Lys Leu Gln Val Gly Phe Ile Asp Phe Val Cys Thr Phe
    530                 535                 540                 
Val Tyr Lys Glu Phe Ser Arg Phe His Glu Glu Ile Leu Pro Met Phe
545                 550                 555                 560 
Asp Arg Leu Gln Asn Asn Arg Lys Glu Trp Lys Ala Leu Ala Asp Glu
                565                 570                 575     
Tyr Glu Ala Lys Val Lys Ala Leu Glu Glu Lys Glu Glu Glu Glu Arg
            580                 585                 590         
Val Ala Ala Lys Lys Val Gly Thr Glu Ile Cys Asn Gly Gly Pro Ala
        595                 600                 605             
Pro Lys Ser Ser Thr Cys Cys Ile Leu
    610                 615         


<210> 199
<211> 276
<212> PRT
<213> Homo sapiens

<400> 199
Glu Ser His Lys Asp Asp Ala His Lys Glu Glu Thr Ser Pro Asn Val
 1               5                  10                  15      
Pro His Leu Leu Gln Glu Ser His Lys Asp His Pro His Lys Glu Glu
            20                  25                  30          
Thr Ser Pro Lys Val Pro His Leu Leu Gln Glu Ser Gln Lys Asp Asp
        35                  40                  45              
Pro His Lys Glu Ala Thr Ser Pro Lys Val Pro His Leu Ile Gln Glu
    50                  55                  60                  
Ser Gln Lys Asp His Pro His Lys Glu Glu Thr Ser Pro Lys Val Pro
65                  70                  75                  80  
His Leu Ile Gln Glu Ser Gln Lys Ala Asp Pro His Lys Glu Asp Thr
                85                  90                  95      
Ser Pro Lys Val Pro His Leu Leu Gln Glu Ser Arg Lys Asp His Pro
            100                 105                 110         
His Lys Glu Glu Thr Ser Pro Lys Val Pro His Leu Leu Gln Glu Ser
        115                 120                 125             
Gln Lys Asp Asp Pro His Lys Glu Ala Thr Ser Pro Lys Val Pro His
    130                 135                 140                 
Leu Ile Gln Glu Ser Gln Lys Asp His Pro His Lys Glu Ala Thr Ser
145                 150                 155                 160 
Pro Thr Val Pro His Leu Leu Gln Glu Ser Gln Lys Asp His Pro His
                165                 170                 175     
Lys Glu Ala Thr Ser Pro Lys Val Pro His Leu Ile Gln Glu Ser Gln
            180                 185                 190         
Lys Asp His Pro His Arg Lys Glu Thr Ser Pro Glu Val Pro Asp Leu
        195                 200                 205             
Leu Gln Glu Ser His Lys Asp His Pro Asn Lys Lys Ala Thr Ser Leu
    210                 215                 220                 
Lys Val Pro His Leu Leu Glu Ser His Lys Ala His Pro His Gln Glu
225                 230                 235                 240 
Ala Ile Pro Ser Ser Leu Arg His Leu Leu Leu Glu Ser Pro Arg Gly
                245                 250                 255     
His Leu His Leu Leu Lys Gly Ala Gly His Pro Asp Leu Pro Arg Asp
            260                 265                 270         
Asn Ser Leu Pro
        275     


<210> 200
<211> 442
<212> PRT
<213> Homo sapiens

<400> 200
Thr Thr Pro Asp Arg Arg Leu Trp Asn Pro Pro Ala Thr Ser Ser Ser
 1               5                  10                  15      
Leu Arg Gln Met Glu Arg Met Leu Pro Leu Leu Thr Leu Gly Leu Leu
            20                  25                  30          
Ala Ala Gly Phe Cys Pro Ala Val Leu Cys His Pro Asn Ser Pro Leu
        35                  40                  45              
Asp Glu Glu Asn Leu Thr Gln Glu Asn Gln Asp Arg Gly Thr His Val
    50                  55                  60                  
Asp Leu Gly Leu Ala Ser Ala Asn Val Asp Phe Ala Phe Ser Leu Tyr
65                  70                  75                  80  
Lys Gln Leu Val Leu Lys Ala Pro Asp Lys Asn Val Ile Phe Ser Pro
                85                  90                  95      
Leu Ser Ile Ser Thr Ala Leu Ala Phe Leu Ser Leu Gly Ala His Asn
            100                 105                 110         
Thr Thr Leu Thr Glu Ile Leu Lys Gly Leu Lys Phe Asn Leu Thr Glu
        115                 120                 125             
Thr Ser Glu Ala Glu Ile His Gln Ser Phe Gln His Leu Leu Arg Thr
    130                 135                 140                 
Leu Asn Gln Ser Ser Asp Glu Leu Gln Leu Ser Met Gly Asn Ala Met
145                 150                 155                 160 
Phe Val Lys Glu Gln Leu Ser Leu Leu Asp Arg Phe Thr Glu Asp Ala
                165                 170                 175     
Lys Arg Leu Tyr Gly Ser Glu Ala Phe Ala Thr Asp Phe Gln Asp Ser
            180                 185                 190         
Ala Ala Ala Lys Lys Leu Ile Asn Asp Tyr Val Lys Asn Gly Thr Arg
        195                 200                 205             
Gly Lys Ile Thr Asp Leu Ile Lys Asp Leu Asp Ser Gln Thr Met Met
    210                 215                 220                 
Val Leu Val Asn Tyr Ile Phe Phe Lys Ala Lys Trp Glu Met Pro Phe
225                 230                 235                 240 
Asp Pro Gln Asp Thr His Gln Ser Arg Phe Tyr Leu Ser Lys Lys Lys
                245                 250                 255     
Trp Val Met Val Pro Met Met Ser Leu His His Leu Thr Ile Pro Tyr
            260                 265                 270         
Phe Arg Asp Glu Glu Leu Ser Cys Thr Val Val Glu Leu Lys Tyr Thr
        275                 280                 285             
Gly Asn Ala Ser Ala Leu Phe Ile Leu Pro Asp Gln Asp Lys Met Glu
    290                 295                 300                 
Glu Val Glu Ala Met Leu Leu Pro Glu Thr Leu Lys Arg Trp Arg Asp
305                 310                 315                 320 
Ser Leu Glu Phe Arg Glu Ile Gly Glu Leu Tyr Leu Pro Lys Phe Ser
                325                 330                 335     
Ile Ser Arg Asp Tyr Asn Leu Asn Asp Ile Leu Leu Gln Leu Gly Ile
            340                 345                 350         
Glu Glu Ala Phe Thr Ser Lys Ala Asp Leu Ser Gly Ile Thr Gly Ala
        355                 360                 365             
Arg Asn Leu Ala Val Ser Gln Val Val His Lys Ala Val Leu Asp Val
    370                 375                 380                 
Phe Glu Glu Gly Thr Glu Ala Ser Ala Ala Thr Ala Val Lys Ile Thr
385                 390                 395                 400 
Leu Leu Ser Ala Leu Val Glu Thr Arg Thr Ile Val Arg Phe Asn Arg
                405                 410                 415     
Pro Phe Leu Met Ile Ile Val Pro Thr Asp Thr Gln Asn Ile Phe Phe
            420                 425                 430         
Met Ser Lys Val Thr Asn Pro Lys Gln Ala
        435                 440         


<210> 201
<211> 247
<212> PRT
<213> Homo sapiens

<400> 201
Met Gln Ala Pro Arg Glu Leu Ala Val Gly Ile Asp Leu Gly Thr Thr
 1               5                  10                  15      
Tyr Ser Cys Val Gly Val Phe Gln Gln Gly Arg Val Glu Ile Leu Ala
            20                  25                  30          
Asn Asp Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp
        35                  40                  45              
Thr Glu Arg Leu Val Gly Asp Ala Ala Lys Asn Gln Ala Ala Leu Asn
    50                  55                  60                  
Pro His Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe
65                  70                  75                  80  
Ala Asp Thr Thr Val Gln Ser Asp Met Lys His Trp Pro Phe Lys Val
                85                  90                  95      
Val Ser Gly Gly Gly Lys Pro Lys Val Arg Val Cys Tyr Arg Gly Glu
            100                 105                 110         
Asp Lys Thr Phe Tyr Pro Glu Glu Ile Ser Ser Met Val Leu Thr Lys
        115                 120                 125             
Met Lys Glu Thr Ala Glu Ala Tyr Leu Gly Gln Pro Val Lys His Ala
    130                 135                 140                 
Val Ile Thr Val Pro Thr Tyr Phe Ser Asn Ser Gln Arg Gln Ala Thr
145                 150                 155                 160 
Lys Asp Ala Gly Ala Ile Ala Gly Leu Lys Val Leu Pro Ile Ile Asn
                165                 170                 175     
Glu Ala Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Arg Arg Arg Ala
            180                 185                 190         
Gly Lys Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp
        195                 200                 205             
Val Ser Val Leu Thr Ile Asp Ala Gly Val Phe Glu Val Lys Ala Thr
    210                 215                 220                 
Ala Gly Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val
225                 230                 235                 240 
Asn His Phe Met Glu Glu Phe
                245         


<210> 202
<211> 1683
<212> PRT
<213> Homo sapiens

<400> 202
Met Pro Gly Ile Lys Val Gly Gly Ser Gly Val Asn Val Asn Ala Lys
 1               5                  10                  15      
Gly Leu Asp Leu Gly Gly Arg Gly Gly Val Gln Val Pro Ala Val Asp
            20                  25                  30          
Ile Ser Ser Ser Leu Gly Gly Arg Pro Val Glu Val Gln Gly Pro Ser
        35                  40                  45              
Leu Glu Ser Gly Asp His Ala Lys Ile Lys Phe Pro Thr Met Lys Val
    50                  55                  60                  
Pro Lys Phe Gly Val Ser Thr Gly Arg Glu Gly Gln Thr Pro Lys Ala
65                  70                  75                  80  
Gly Leu Arg Val Ser Ala Pro Glu Val Ser Val Gly His Lys Gly Gly
                85                  90                  95      
Lys Pro Gly Leu Thr Ile Gln Ala Pro Gln Leu Glu Val Ser Val Pro
            100                 105                 110         
Ser Ala Asn Ile Glu Gly Leu Glu Gly Lys Leu Lys Gly Pro Gln Ile
        115                 120                 125             
Thr Gly Pro Ser Leu Glu Gly Asp Leu Gly Leu Lys Gly Ala Lys Pro
    130                 135                 140                 
Gln Gly His Ile Gly Val Asp Ala Ser Ala Pro Gln Ile Gly Gly Ser
145                 150                 155                 160 
Ile Thr Gly Pro Ser Val Glu Val Gln Ala Pro Asp Ile Asp Val Gln
                165                 170                 175     
Gly Pro Gly Ser Lys Leu Asn Val Pro Lys Met Lys Val Pro Lys Phe
            180                 185                 190         
Ser Val Ser Gly Ala Lys Gly Glu Glu Thr Gly Ile Asp Val Thr Leu
        195                 200                 205             
Pro Thr Gly Glu Val Thr Val Pro Gly Val Ser Gly Asp Val Ser Leu
    210                 215                 220                 
Pro Glu Ile Ala Thr Gly Gly Leu Glu Gly Lys Met Lys Gly Thr Lys
225                 230                 235                 240 
Val Lys Thr Pro Glu Met Ile Ile Gln Lys Pro Lys Ile Ser Met Gln
                245                 250                 255     
Asp Val Asp Leu Ser Leu Gly Ser Pro Lys Leu Lys Gly Asp Ile Lys
            260                 265                 270         
Val Ser Ala Pro Gly Val Gln Gly Asp Val Lys Gly Pro Gln Val Ala
        275                 280                 285             
Leu Lys Gly Ser Arg Val Asp Ile Glu Thr Pro Asn Leu Glu Gly Thr
    290                 295                 300                 
Leu Thr Gly Pro Arg Leu Gly Ser Pro Ser Gly Lys Thr Gly Thr Cys
305                 310                 315                 320 
Arg Ile Ser Met Ser Glu Val Asp Leu Asn Val Ala Ala Pro Lys Val
                325                 330                 335     
Lys Gly Gly Val Asp Val Thr Leu Pro Arg Val Glu Gly Lys Val Lys
            340                 345                 350         
Val Pro Glu Val Asp Val Arg Gly Pro Lys Val Asp Val Ser Ala Pro
        355                 360                 365             
Asp Val Glu Ala His Gly Pro Glu Trp Asn Leu Lys Met Pro Lys Met
    370                 375                 380                 
Lys Met Pro Thr Phe Ser Thr Pro Gly Ala Lys Gly Glu Gly Pro Asp
385                 390                 395                 400 
Val His Met Thr Leu Pro Lys Gly Asp Ile Ser Ile Ser Gly Pro Lys
                405                 410                 415     
Val Asn Val Glu Ala Pro Asp Val Asn Leu Glu Gly Leu Gly Gly Lys
            420                 425                 430         
Leu Lys Gly Pro Asp Val Lys Leu Pro Asp Met Ser Val Lys Thr Pro
        435                 440                 445             
Lys Ile Ser Met Pro Asp Val Asp Leu His Val Lys Gly Thr Lys Val
    450                 455                 460                 
Lys Gly Glu Tyr Asp Val Thr Val Pro Lys Leu Glu Gly Glu Leu Lys
465                 470                 475                 480 
Gly Pro Lys Val Asp Ile Asp Ala Pro Asp Val Asp Val His Gly Pro
                485                 490                 495     
Asp Trp His Leu Lys Met Pro Lys Met Lys Met Pro Lys Phe Ser Val
            500                 505                 510         
Pro Gly Phe Lys Ala Glu Gly Pro Glu Val Asp Val Asn Leu Pro Lys
        515                 520                 525             
Ala Asp Val Asp Ile Ser Gly Pro Lys Ile Asp Val Thr Ala Pro Asp
    530                 535                 540                 
Val Ser Ile Glu Glu Pro Glu Gly Lys Leu Lys Gly Pro Lys Phe Lys
545                 550                 555                 560 
Met Pro Glu Met Asn Ile Lys Val Pro Lys Ile Ser Met Pro Asp Val
                565                 570                 575     
Asp Leu His Leu Lys Gly Pro Asn Val Lys Gly Glu Tyr Asp Val Thr
            580                 585                 590         
Met Pro Lys Val Glu Ser Glu Ile Lys Val Pro Asp Val Glu Leu Lys
        595                 600                 605             
Ser Ala Lys Met Asp Ile Asp Val Pro Asp Val Glu Val Gln Gly Pro
    610                 615                 620                 
Asp Trp His Leu Lys Met Pro Lys Met Lys Met Pro Lys Phe Ser Met
625                 630                 635                 640 
Pro Gly Phe Lys Ala Glu Gly Pro Glu Val Asp Val Asn Leu Pro Lys
                645                 650                 655     
Ala Asp Val Asp Ile Ser Gly Pro Lys Val Gly Val Glu Val Pro Asp
            660                 665                 670         
Val Asn Ile Glu Gly Pro Glu Gly Lys Leu Lys Gly Pro Lys Phe Lys
        675                 680                 685             
Met Pro Glu Met Asn Ile Lys Ala Pro Lys Ile Ser Met Pro Asp Val
    690                 695                 700                 
Asp Leu His Met Lys Gly Pro Lys Val Lys Gly Glu Tyr Asp Met Thr
705                 710                 715                 720 
Val Pro Lys Leu Glu Gly Asp Leu Lys Gly Pro Lys Val Asp Val Ser
                725                 730                 735     
Ala Pro Asp Val Glu Met Gln Gly Pro Asp Trp Asn Leu Lys Met Pro
            740                 745                 750         
Lys Ile Lys Met Pro Lys Phe Ser Met Pro Ser Leu Lys Gly Glu Gly
        755                 760                 765             
Pro Glu Phe Asp Val Asn Leu Ser Lys Ala Asn Val Asp Ile Ser Ala
    770                 775                 780                 
Pro Lys Val Asp Thr Asn Ala Pro Asp Leu Ser Leu Glu Gly Pro Glu
785                 790                 795                 800 
Gly Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met His Phe Arg
                805                 810                 815     
Ala Pro Lys Met Ser Leu Pro Asp Val Asp Leu Asp Leu Lys Gly Pro
            820                 825                 830         
Lys Met Lys Gly Asn Val Asp Ile Ser Ala Pro Lys Ile Glu Gly Glu
        835                 840                 845             
Met Gln Val Pro Asp Val Asp Ile Arg Gly Pro Lys Val Asp Ile Lys
    850                 855                 860                 
Ala Pro Asp Val Glu Gly Gln Gly Leu Asp Trp Ser Leu Lys Ile Pro
865                 870                 875                 880 
Lys Met Lys Met Pro Lys Phe Ser Met Pro Ser Leu Lys Gly Glu Gly
                885                 890                 895     
Pro Glu Val Asp Val Asn Leu Pro Lys Ala Asp Val Asp Val Ser Gly
            900                 905                 910         
Pro Lys Val Asp Ile Glu Ala Pro Asp Val Ser Leu Glu Gly Pro Glu
        915                 920                 925             
Gly Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met His Phe Lys
    930                 935                 940                 
Thr Pro Lys Ile Ser Met Pro Asp Val Asp Leu His Leu Lys Gly Pro
945                 950                 955                 960 
Lys Val Lys Gly Asp Val Asp Val Ser Val Pro Lys Val Glu Gly Glu
                965                 970                 975     
Met Lys Val Pro Asp Val Glu Ile Lys Gly Pro Lys Met Asp Ile Asp
            980                 985                 990         
Ala Pro Asp Val Glu Val Gln Gly Pro Asp Trp His Leu Lys Met Pro
        995                 1000                1005            
Lys Met Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Gly Glu Gly
    1010                1015                1020                
Arg Glu Val Asp Val Asn Leu Pro Lys Ala Asp Ile Asp Val Ser Gly
1025                1030                1035                1040
Pro Lys Val Asp Val Glu Val Pro Asp Val Ser Leu Glu Gly Pro Glu
                1045                1050                1055    
Gly Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met His Phe Lys
            1060                1065                1070        
Ala Pro Lys Ile Ser Met Pro Asp Val Asp Leu Asn Leu Lys Gly Pro
        1075                1080                1085            
Lys Leu Lys Gly Asp Val Asp Val Ser Leu Pro Glu Val Glu Gly Glu
    1090                1095                1100                
Met Lys Val Pro Asp Val Asp Ile Lys Gly Pro Lys Val Asp Ile Ser
1105                1110                1115                1120
Ala Pro Asp Val Asp Val His Gly Pro Asp Trp His Leu Lys Met Pro
                1125                1130                1135    
Lys Val Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Gly Glu Gly
            1140                1145                1150        
Pro Glu Val Asp Val Lys Leu Pro Lys Ala Asp Val Asp Val Ser Gly
        1155                1160                1165            
Pro Lys Met Asp Ala Glu Val Pro Asp Val Asn Ile Glu Gly Pro Asp
    1170                1175                1180                
Ala Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met Ser Ile Lys
1185                1190                1195                1200
Pro Gln Lys Ile Ser Ile Pro Asp Val Gly Leu His Leu Lys Gly Pro
                1205                1210                1215    
Lys Met Lys Gly Asp Tyr Asp Val Thr Val Pro Lys Val Glu Gly Glu
            1220                1225                1230        
Ile Lys Ala Pro Asp Val Asp Ile Lys Gly Pro Lys Val Asp Ile Asn
        1235                1240                1245            
Ala Pro Asp Val Glu Val His Gly Pro Asp Trp His Leu Lys Met Pro
    1250                1255                1260                
Lys Val Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Gly Glu Gly
1265                1270                1275                1280
Pro Glu Val Asp Met Asn Leu Pro Lys Ala Asp Leu Gly Val Ser Gly
                1285                1290                1295    
Pro Lys Val Asp Ile Asp Val Pro Asp Val Asn Leu Glu Ala Pro Glu
            1300                1305                1310        
Gly Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Ser Met Asn Ile Gln
        1315                1320                1325            
Thr His Lys Ile Ser Met Pro Asp Val Gly Leu Asn Leu Lys Ala Pro
    1330                1335                1340                
Lys Leu Lys Thr Asp Val Asp Val Ser Leu Pro Lys Val Glu Gly Asp
1345                1350                1355                1360
Leu Lys Gly Pro Glu Ile Asp Val Lys Ala Pro Lys Met Asp Val Asn
                1365                1370                1375    
Val Gly Asp Ile Asp Ile Glu Gly Pro Glu Gly Lys Leu Lys Gly Pro
            1380                1385                1390        
Lys Phe Lys Met Pro Glu Met His Phe Lys Ala Pro Lys Ile Ser Met
        1395                1400                1405            
Pro Asp Val Asp Leu His Leu Lys Gly Pro Lys Val Lys Gly Asp Met
    1410                1415                1420                
Asp Val Ser Val Pro Lys Val Glu Gly Glu Met Lys Val Pro Asp Val
1425                1430                1435                1440
Asp Ile Lys Gly Pro Lys Val Asp Ile Asp Ala Pro Asp Val Glu Val
                1445                1450                1455    
His Asp Pro Asp Trp His Leu Lys Met Pro Lys Met Lys Met Pro Lys
            1460                1465                1470        
Phe Ser Met Pro Gly Phe Lys Ala Glu Gly Pro Glu Val Asp Val Asn
        1475                1480                1485            
Leu Arg Lys Ala Asp Ile Asp Val Ser Gly Pro Ser Val Asp Thr Asp
    1490                1495                1500                
Ala Pro Asp Leu Asp Ile Glu Gly Pro Glu Gly Lys Leu Lys Gly Ser
1505                1510                1515                1520
Lys Phe Lys Met Pro Lys Leu Asn Ile Lys Ala Pro Lys Val Ser Met
                1525                1530                1535    
Pro Asp Val Asp Leu Asn Leu Lys Gly Pro Lys Leu Lys Gly Glu Ile
            1540                1545                1550        
Asp Ala Ser Val Pro Glu Leu Glu Gly Asp Leu Arg Gly Pro Gln Val
        1555                1560                1565            
Asp Val Lys Gly Pro Leu Val Glu Ala Glu Val Pro Asp Val Asp Leu
    1570                1575                1580                
Glu Cys Pro Asp Ala Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu
1585                1590                1595                1600
Met His Phe Lys Ala Pro Lys Ile Ser Met Pro Asp Val Asp Leu His
                1605                1610                1615    
Leu Lys Gly Pro Lys Val Lys Gly Asp Ala Asp Val Ser Val Pro Lys
            1620                1625                1630        
Leu Glu Gly Asp Leu Thr Gly Pro Ser Val Gly Val Glu Val Pro Asp
        1635                1640                1645            
Val Glu Leu Glu Cys Pro Asp Ala Lys Leu Lys Gly Pro Lys Phe Lys
    1650                1655                1660                
Met Pro Asp Met His Phe Lys Ala Pro Lys Ile Ser Met Pro Asp Val
1665                1670                1675                1680
Asp Leu His
            


<210> 203
<211> 1683
<212> PRT
<213> Homo sapiens

<400> 203
Met Pro Gly Ile Lys Val Gly Gly Ser Gly Val Asn Val Asn Ala Lys
 1               5                  10                  15      
Gly Leu Asp Leu Gly Gly Arg Gly Gly Val Gln Val Pro Ala Val Asp
            20                  25                  30          
Ile Ser Ser Ser Leu Gly Gly Arg Pro Val Glu Val Gln Gly Pro Ser
        35                  40                  45              
Leu Glu Ser Gly Asp His Ala Lys Ile Lys Phe Pro Thr Met Lys Val
    50                  55                  60                  
Pro Lys Phe Gly Val Ser Thr Gly Arg Glu Gly Gln Thr Pro Lys Ala
65                  70                  75                  80  
Gly Leu Arg Val Ser Ala Pro Glu Val Ser Val Gly His Lys Gly Gly
                85                  90                  95      
Lys Pro Gly Leu Thr Ile Gln Ala Pro Gln Leu Glu Val Ser Val Pro
            100                 105                 110         
Ser Ala Asn Ile Glu Gly Leu Glu Gly Lys Leu Lys Gly Pro Gln Ile
        115                 120                 125             
Thr Gly Pro Ser Leu Glu Gly Asp Leu Gly Leu Lys Gly Ala Lys Pro
    130                 135                 140                 
Gln Gly His Ile Gly Val Asp Ala Ser Ala Pro Gln Ile Gly Gly Ser
145                 150                 155                 160 
Ile Thr Gly Pro Ser Val Glu Val Gln Ala Pro Asp Ile Asp Val Gln
                165                 170                 175     
Gly Pro Gly Ser Lys Leu Asn Val Pro Lys Met Lys Val Pro Lys Phe
            180                 185                 190         
Ser Val Ser Gly Ala Lys Gly Glu Glu Thr Gly Ile Asp Val Thr Leu
        195                 200                 205             
Pro Thr Gly Glu Val Thr Val Pro Gly Val Ser Gly Asp Val Ser Leu
    210                 215                 220                 
Pro Glu Ile Ala Thr Gly Gly Leu Glu Gly Lys Met Lys Gly Thr Lys
225                 230                 235                 240 
Val Lys Thr Pro Glu Met Ile Ile Gln Lys Pro Lys Ile Ser Met Gln
                245                 250                 255     
Asp Val Asp Leu Ser Leu Gly Ser Pro Lys Leu Lys Gly Asp Ile Lys
            260                 265                 270         
Val Ser Ala Pro Gly Val Gln Gly Asp Val Lys Gly Pro Gln Val Ala
        275                 280                 285             
Leu Lys Gly Ser Arg Val Asp Ile Glu Thr Pro Asn Leu Glu Gly Thr
    290                 295                 300                 
Leu Thr Gly Pro Arg Leu Gly Ser Pro Ser Gly Lys Thr Gly Thr Cys
305                 310                 315                 320 
Arg Ile Ser Met Ser Glu Val Asp Leu Asn Val Ala Ala Pro Lys Val
                325                 330                 335     
Lys Gly Gly Val Asp Val Thr Leu Pro Arg Val Glu Gly Lys Val Lys
            340                 345                 350         
Val Pro Glu Val Asp Val Arg Gly Pro Lys Val Asp Val Ser Ala Pro
        355                 360                 365             
Asp Val Glu Ala His Gly Pro Glu Trp Asn Leu Lys Met Pro Lys Met
    370                 375                 380                 
Lys Met Pro Thr Phe Ser Thr Pro Gly Ala Lys Gly Glu Gly Pro Asp
385                 390                 395                 400 
Val His Met Thr Leu Pro Lys Gly Asp Ile Ser Ile Ser Gly Pro Lys
                405                 410                 415     
Val Asn Val Glu Ala Pro Asp Val Asn Leu Glu Gly Leu Gly Gly Lys
            420                 425                 430         
Leu Lys Gly Pro Asp Val Lys Leu Pro Asp Met Ser Val Lys Thr Pro
        435                 440                 445             
Lys Ile Ser Met Pro Asp Val Asp Leu His Val Lys Gly Thr Lys Val
    450                 455                 460                 
Lys Gly Glu Tyr Asp Val Thr Val Pro Lys Leu Glu Gly Glu Leu Lys
465                 470                 475                 480 
Gly Pro Lys Val Asp Ile Asp Ala Pro Asp Val Asp Val His Gly Pro
                485                 490                 495     
Asp Trp His Leu Lys Met Pro Lys Met Lys Met Pro Lys Phe Ser Val
            500                 505                 510         
Pro Gly Phe Lys Ala Glu Gly Pro Glu Val Asp Val Asn Leu Pro Lys
        515                 520                 525             
Ala Asp Val Asp Ile Ser Gly Pro Lys Ile Asp Val Thr Ala Pro Asp
    530                 535                 540                 
Val Ser Ile Glu Glu Pro Glu Gly Lys Leu Lys Gly Pro Lys Phe Lys
545                 550                 555                 560 
Met Pro Glu Met Asn Ile Lys Val Pro Lys Ile Ser Met Pro Asp Val
                565                 570                 575     
Asp Leu His Leu Lys Gly Pro Asn Val Lys Gly Glu Tyr Asp Val Thr
            580                 585                 590         
Met Pro Lys Val Glu Ser Glu Ile Lys Val Pro Asp Val Glu Leu Lys
        595                 600                 605             
Ser Ala Lys Met Asp Ile Asp Val Pro Asp Val Glu Val Gln Gly Pro
    610                 615                 620                 
Asp Trp His Leu Lys Met Pro Lys Met Lys Met Pro Lys Phe Ser Met
625                 630                 635                 640 
Pro Gly Phe Lys Ala Glu Gly Pro Glu Val Asp Val Asn Leu Pro Lys
                645                 650                 655     
Ala Asp Val Asp Ile Ser Gly Pro Lys Val Gly Val Glu Val Pro Asp
            660                 665                 670         
Val Asn Ile Glu Gly Pro Glu Gly Lys Leu Lys Gly Pro Lys Phe Lys
        675                 680                 685             
Met Pro Glu Met Asn Ile Lys Ala Pro Lys Ile Ser Met Pro Asp Val
    690                 695                 700                 
Asp Leu His Met Lys Gly Pro Lys Val Lys Gly Glu Tyr Asp Met Thr
705                 710                 715                 720 
Val Pro Lys Leu Glu Gly Asp Leu Lys Gly Pro Lys Val Asp Val Ser
                725                 730                 735     
Ala Pro Asp Val Glu Met Gln Gly Pro Asp Trp Asn Leu Lys Met Pro
            740                 745                 750         
Lys Ile Lys Met Pro Lys Phe Ser Met Pro Ser Leu Lys Gly Glu Gly
        755                 760                 765             
Pro Glu Phe Asp Val Asn Leu Ser Lys Ala Asn Val Asp Ile Ser Ala
    770                 775                 780                 
Pro Lys Val Asp Thr Asn Ala Pro Asp Leu Ser Leu Glu Gly Pro Glu
785                 790                 795                 800 
Gly Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met His Phe Arg
                805                 810                 815     
Ala Pro Lys Met Ser Leu Pro Asp Val Asp Leu Asp Leu Lys Gly Pro
            820                 825                 830         
Lys Met Lys Gly Asn Val Asp Ile Ser Ala Pro Lys Ile Glu Gly Glu
        835                 840                 845             
Met Gln Val Pro Asp Val Asp Ile Arg Gly Pro Lys Val Asp Ile Lys
    850                 855                 860                 
Ala Pro Asp Val Glu Gly Gln Gly Leu Asp Trp Ser Leu Lys Ile Pro
865                 870                 875                 880 
Lys Met Lys Met Pro Lys Phe Ser Met Pro Ser Leu Lys Gly Glu Gly
                885                 890                 895     
Pro Glu Val Asp Val Asn Leu Pro Lys Ala Asp Val Asp Val Ser Gly
            900                 905                 910         
Pro Lys Val Asp Ile Glu Ala Pro Asp Val Ser Leu Glu Gly Pro Glu
        915                 920                 925             
Gly Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met His Phe Lys
    930                 935                 940                 
Thr Pro Lys Ile Ser Met Pro Asp Val Asp Leu His Leu Lys Gly Pro
945                 950                 955                 960 
Lys Val Lys Gly Asp Val Asp Val Ser Val Pro Lys Val Glu Gly Glu
                965                 970                 975     
Met Lys Val Pro Asp Val Glu Ile Lys Gly Pro Lys Met Asp Ile Asp
            980                 985                 990         
Ala Pro Asp Val Glu Val Gln Gly Pro Asp Trp His Leu Lys Met Pro
        995                 1000                1005            
Lys Met Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Gly Glu Gly
    1010                1015                1020                
Arg Glu Val Asp Val Asn Leu Pro Lys Ala Asp Ile Asp Val Ser Gly
1025                1030                1035                1040
Pro Lys Val Asp Val Glu Val Pro Asp Val Ser Leu Glu Gly Pro Glu
                1045                1050                1055    
Gly Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met His Phe Lys
            1060                1065                1070        
Ala Pro Lys Ile Ser Met Pro Asp Val Asp Leu Asn Leu Lys Gly Pro
        1075                1080                1085            
Lys Leu Lys Gly Asp Val Asp Val Ser Leu Pro Glu Val Glu Gly Glu
    1090                1095                1100                
Met Lys Val Pro Asp Val Asp Ile Lys Gly Pro Lys Val Asp Ile Ser
1105                1110                1115                1120
Ala Pro Asp Val Asp Val His Gly Pro Asp Trp His Leu Lys Met Pro
                1125                1130                1135    
Lys Val Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Gly Glu Gly
            1140                1145                1150        
Pro Glu Val Asp Val Lys Leu Pro Lys Ala Asp Val Asp Val Ser Gly
        1155                1160                1165            
Pro Lys Met Asp Ala Glu Val Pro Asp Val Asn Ile Glu Gly Pro Asp
    1170                1175                1180                
Ala Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met Ser Ile Lys
1185                1190                1195                1200
Pro Gln Lys Ile Ser Ile Pro Asp Val Gly Leu His Leu Lys Gly Pro
                1205                1210                1215    
Lys Met Lys Gly Asp Tyr Asp Val Thr Val Pro Lys Val Glu Gly Glu
            1220                1225                1230        
Ile Lys Ala Pro Asp Val Asp Ile Lys Gly Pro Lys Val Asp Ile Asn
        1235                1240                1245            
Ala Pro Asp Val Glu Val His Gly Pro Asp Trp His Leu Lys Met Pro
    1250                1255                1260                
Lys Val Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Gly Glu Gly
1265                1270                1275                1280
Pro Glu Val Asp Met Asn Leu Pro Lys Ala Asp Leu Gly Val Ser Gly
                1285                1290                1295    
Pro Lys Val Asp Ile Asp Val Pro Asp Val Asn Leu Glu Ala Pro Glu
            1300                1305                1310        
Gly Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Ser Met Asn Ile Gln
        1315                1320                1325            
Thr His Lys Ile Ser Met Pro Asp Val Gly Leu Asn Leu Lys Ala Pro
    1330                1335                1340                
Lys Leu Lys Thr Asp Val Asp Val Ser Leu Pro Lys Val Glu Gly Asp
1345                1350                1355                1360
Leu Lys Gly Pro Glu Ile Asp Val Lys Ala Pro Lys Met Asp Val Asn
                1365                1370                1375    
Val Gly Asp Ile Asp Ile Glu Gly Pro Glu Gly Lys Leu Lys Gly Pro
            1380                1385                1390        
Lys Phe Lys Met Pro Glu Met His Phe Lys Ala Pro Lys Ile Ser Met
        1395                1400                1405            
Pro Asp Val Asp Leu His Leu Lys Gly Pro Lys Val Lys Gly Asp Met
    1410                1415                1420                
Asp Val Ser Val Pro Lys Val Glu Gly Glu Met Lys Val Pro Asp Val
1425                1430                1435                1440
Asp Ile Lys Gly Pro Lys Val Asp Ile Asp Ala Pro Asp Val Glu Val
                1445                1450                1455    
His Asp Pro Asp Trp His Leu Lys Met Pro Lys Met Lys Met Pro Lys
            1460                1465                1470        
Phe Ser Met Pro Gly Phe Lys Ala Glu Gly Pro Glu Val Asp Val Asn
        1475                1480                1485            
Leu Arg Lys Ala Asp Ile Asp Val Ser Gly Pro Ser Val Asp Thr Asp
    1490                1495                1500                
Ala Pro Asp Leu Asp Ile Glu Gly Pro Glu Gly Lys Leu Lys Gly Ser
1505                1510                1515                1520
Lys Phe Lys Met Pro Lys Leu Asn Ile Lys Ala Pro Lys Val Ser Met
                1525                1530                1535    
Pro Asp Val Asp Leu Asn Leu Lys Gly Pro Lys Leu Lys Gly Glu Ile
            1540                1545                1550        
Asp Ala Ser Val Pro Glu Leu Glu Gly Asp Leu Arg Gly Pro Gln Val
        1555                1560                1565            
Asp Val Lys Gly Pro Leu Val Glu Ala Glu Val Pro Asp Val Asp Leu
    1570                1575                1580                
Glu Cys Pro Asp Ala Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu
1585                1590                1595                1600
Met His Phe Lys Ala Pro Lys Ile Ser Met Pro Asp Val Asp Leu His
                1605                1610                1615    
Leu Lys Gly Pro Lys Val Lys Gly Asp Ala Asp Val Ser Val Pro Lys
            1620                1625                1630        
Leu Glu Gly Asp Leu Thr Gly Pro Ser Val Gly Val Glu Val Pro Asp
        1635                1640                1645            
Val Glu Leu Glu Cys Pro Asp Ala Lys Leu Lys Gly Pro Lys Phe Lys
    1650                1655                1660                
Met Pro Asp Met His Phe Lys Ala Pro Lys Ile Ser Met Pro Asp Val
1665                1670                1675                1680
Asp Leu His
            


<210> 204
<211> 1277
<212> PRT
<213> Homo sapiens

<400> 204
Thr Leu Pro Lys Val Glu Gly Asp Leu Lys Gly Pro Glu Ala Asp Ile
 1               5                  10                  15      
Lys Gly Pro Lys Val Asp Ile Asn Thr Pro Asp Val Asp Val His Gly
            20                  25                  30          
Pro Asp Trp His Leu Lys Met Pro Lys Val Lys Met Pro Lys Phe Ser
        35                  40                  45              
Met Pro Gly Phe Lys Gly Glu Gly Pro Asp Val Asp Val Asn Leu Pro
    50                  55                  60                  
Lys Ala Asp Ile Asp Val Ser Gly Pro Lys Val Asp Val Asp Val Pro
65                  70                  75                  80  
Asp Val Asn Ile Glu Gly Pro Asp Ala Lys Leu Lys Gly Pro Lys Phe
                85                  90                  95      
Lys Met Pro Glu Met Ser Ile Lys Ala Pro Lys Ile Ser Met Pro Asp
            100                 105                 110         
Ile Asp Leu Asn Leu Lys Gly Pro Lys Val Lys Gly Asp Val Asp Val
        115                 120                 125             
Thr Leu Pro Lys Val Glu Gly Asp Leu Lys Gly Pro Glu Ala Asp Ile
    130                 135                 140                 
Lys Gly Pro Lys Val Asp Ile Asn Thr Pro Asp Val Asp Val His Gly
145                 150                 155                 160 
Pro Asp Trp His Leu Lys Met Pro Lys Val Lys Met Pro Lys Phe Ser
                165                 170                 175     
Met Pro Gly Phe Lys Gly Glu Gly Pro Asp Val Asp Val Ser Leu Pro
            180                 185                 190         
Lys Ala Asp Ile Asp Val Ser Gly Pro Lys Val Asp Val Asp Ile Pro
        195                 200                 205             
Asp Val Asn Ile Glu Gly Pro Asp Pro Lys Leu Lys Val Pro Lys Val
    210                 215                 220                 
Lys Met Pro Glu Ile Asn Ile Lys Ala Pro Lys Ile Ser Ile Pro Asp
225                 230                 235                 240 
Val Asp Leu Asp Leu Lys Gly Pro Lys Val Lys Gly Asp Phe Asp Val
                245                 250                 255     
Ser Val Pro Lys Val Glu Gly Thr Leu Lys Gly Pro Glu Val Asp Leu
            260                 265                 270         
Lys Gly Pro Arg Leu Asp Phe Glu Gly Pro Asp Ala Lys Leu Ser Gly
        275                 280                 285             
Pro Ser Leu Lys Met Pro Ser Leu Glu Ile Ser Ala Pro Lys Val Thr
    290                 295                 300                 
Ala Pro Asp Val Asp Leu His Leu Lys Ala Pro Lys Ile Gly Phe Ser
305                 310                 315                 320 
Gly Pro Lys Leu Glu Gly Gly Glu Val Asp Leu Lys Gly Pro Lys Val
                325                 330                 335     
Glu Ala Pro Ser Leu Asp Val His Met Asp Ser Pro Asp Ile Asn Ile
            340                 345                 350         
Glu Gly Pro Asp Val Lys Ile Pro Lys Phe Lys Lys Pro Lys Phe Gly
        355                 360                 365             
Phe Gly Pro Lys Ser Pro Lys Ala Asp Ile Lys Ser Pro Ser Leu Asp
    370                 375                 380                 
Val Thr Val Pro Glu Ala Glu Leu Asn Leu Glu Thr Pro Glu Ile Ser
385                 390                 395                 400 
Val Gly Gly Lys Gly Lys Lys Ser Lys Phe Lys Met Pro Lys Ile His
                405                 410                 415     
Met Ser Gly Pro Lys Ile Lys Ala Lys Lys Gln Gly Phe Asp Leu Asn
            420                 425                 430         
Val Pro Gly Gly Glu Ile Asp Ala Ser Leu Lys Ala Pro Asp Val Asp
        435                 440                 445             
Val Asn Ile Ala Gly Pro Asp Ala Ala Leu Lys Val Asp Val Lys Ser
    450                 455                 460                 
Pro Lys Thr Lys Lys Thr Met Phe Gly Lys Met Tyr Phe Pro Asp Val
465                 470                 475                 480 
Glu Phe Asp Ile Lys Ser Pro Lys Phe Lys Ala Glu Ala Pro Leu Pro
                485                 490                 495     
Ser Pro Lys Leu Glu Gly Glu Leu Gln Ala Pro Asp Leu Glu Leu Ser
            500                 505                 510         
Leu Pro Ala Ile His Val Glu Gly Leu Asp Ile Lys Ala Lys Ala Pro
        515                 520                 525             
Lys Val Lys Met Pro Asp Val Asp Ile Ser Val Pro Lys Ile Glu Gly
    530                 535                 540                 
Asp Leu Lys Gly Pro Lys Val Gln Ala Asn Leu Gly Ala Pro Asp Ile
545                 550                 555                 560 
Asn Ile Glu Gly Leu Asp Ala Lys Val Lys Thr Pro Ser Phe Gly Ile
                565                 570                 575     
Ser Ala Pro Gln Val Ser Ile Pro Asp Val Asn Val Asn Leu Lys Gly
            580                 585                 590         
Pro Lys Ile Lys Gly Asp Val Pro Ser Val Gly Leu Glu Gly Pro Asp
        595                 600                 605             
Val Asp Leu Gln Gly Pro Glu Ala Lys Ile Lys Phe Pro Lys Phe Ser
    610                 615                 620                 
Met Pro Lys Ile Gly Ile Pro Gly Val Lys Met Glu Gly Gly Gly Ala
625                 630                 635                 640 
Glu Val His Ala Gln Leu Pro Ser Leu Glu Gly Asp Leu Arg Gly Pro
                645                 650                 655     
Asp Val Lys Leu Glu Gly Pro Asp Val Ser Leu Lys Gly Pro Gly Val
            660                 665                 670         
Asp Leu Pro Ser Val Asn Leu Ser Met Pro Lys Val Ser Gly Pro Asp
        675                 680                 685             
Leu Asp Leu Asn Leu Lys Gly Pro Ser Leu Lys Gly Asp Leu Asp Ala
    690                 695                 700                 
Ser Val Pro Ser Met Lys Val His Ala Pro Gly Leu Asn Leu Ser Gly
705                 710                 715                 720 
Val Gly Gly Lys Met Gln Val Gly Gly Asp Gly Val Lys Val Pro Gly
                725                 730                 735     
Ile Asp Ala Thr Thr Lys Leu Asn Val Gly Ala Pro Asp Val Thr Leu
            740                 745                 750         
Arg Gly Pro Ser Leu Gln Gly Asp Leu Ala Val Ser Gly Asp Ile Lys
        755                 760                 765             
Cys Pro Lys Val Ser Val Gly Ala Pro Asp Leu Ser Leu Glu Ala Ser
    770                 775                 780                 
Glu Gly Ser Ile Lys Leu Pro Lys Met Lys Leu Pro Gln Phe Gly Ile
785                 790                 795                 800 
Ser Thr Pro Gly Ser Asp Leu His Val Asn Ala Lys Gly Pro Gln Val
                805                 810                 815     
Ser Gly Glu Leu Lys Gly Pro Gly Val Asp Val Asn Leu Lys Gly Ser
            820                 825                 830         
Arg Ile Ser Ala Pro Asn Val Asp Phe Asn Leu Glu Gly Pro Lys Val
        835                 840                 845             
Lys Gly Ser Leu Gly Ala Thr Gly Glu Ile Lys Gly Pro Thr Val Gly
    850                 855                 860                 
Gly Gly Leu Pro Gly Ile Gly Val Gln Gly Leu Glu Gly Asn Leu Gln
865                 870                 875                 880 
Met Pro Gly Ile Lys Ser Ser Gly Cys Asp Val Asn Leu Pro Gly Val
                885                 890                 895     
Asn Val Lys Leu Pro Thr Gly Gln Ile Ser Gly Pro Glu Ile Lys Gly
            900                 905                 910         
Gly Leu Lys Gly Ser Glu Val Gly Phe His Gly Ala Ala Pro Asp Ile
        915                 920                 925             
Ser Val Lys Gly Pro Ala Phe Asn Met Ala Ser Pro Glu Ser Asp Phe
    930                 935                 940                 
Gly Ile Asn Leu Lys Gly Pro Lys Ile Lys Gly Gly Ala Asp Val Ser
945                 950                 955                 960 
Gly Gly Val Ser Ala Pro Asp Ile Ser Leu Gly Glu Gly His Leu Ser
                965                 970                 975     
Val Lys Gly Ser Gly Gly Glu Trp Lys Gly Pro Gln Val Ser Ser Ala
            980                 985                 990         
Leu Asn Leu Asp Thr Ser Lys Phe Ala Gly Gly Leu His Phe Ser Gly
        995                 1000                1005            
Pro Lys Val Glu Gly Gly Val Lys Gly Gly Gln Ile Gly Leu Gln Ala
    1010                1015                1020                
Pro Gly Leu Ser Val Ser Gly Pro Gln Gly His Leu Glu Ser Gly Ser
1025                1030                1035                1040
Gly Lys Val Thr Phe Pro Lys Met Lys Ile Pro Lys Phe Thr Phe Ser
                1045                1050                1055    
Gly Arg Glu Leu Val Gly Arg Glu Met Gly Val Asp Val His Phe Pro
            1060                1065                1070        
Lys Ala Glu Ala Ser Ile Gln Ala Gly Ala Gly Asp Gly Glu Trp Glu
        1075                1080                1085            
Glu Ser Glu Val Lys Leu Lys Lys Ser Lys Ile Lys Met Pro Lys Phe
    1090                1095                1100                
Asn Phe Ser Lys Pro Lys Gly Lys Gly Gly Val Thr Gly Ser Pro Glu
1105                1110                1115                1120
Ala Ser Ile Ser Gly Ser Lys Gly Asp Leu Lys Ser Ser Lys Ala Ser
                1125                1130                1135    
Leu Gly Ser Leu Glu Gly Glu Ala Glu Ala Glu Ala Ser Ser Pro Lys
            1140                1145                1150        
Gly Lys Phe Ser Leu Phe Lys Ser Lys Lys Pro Arg His Arg Ser Asn
        1155                1160                1165            
Ser Phe Ser Asp Glu Arg Glu Phe Ser Gly Pro Ser Thr Pro Thr Gly
    1170                1175                1180                
Thr Leu Glu Phe Glu Gly Gly Glu Val Ser Leu Glu Gly Gly Lys Val
1185                1190                1195                1200
Lys Gly Lys His Gly Lys Leu Lys Phe Gly Thr Phe Gly Gly Leu Gly
                1205                1210                1215    
Ser Lys Ser Lys Gly His Tyr Glu Val Thr Gly Ser Asp Asp Glu Thr
            1220                1225                1230        
Gly Lys Leu Gln Gly Ser Gly Val Ser Leu Ala Ser Lys Lys Ser Arg
        1235                1240                1245            
Leu Ser Ser Ser Ser Ser Asn Asp Ser Gly Asn Lys Val Gly Ile Gln
    1250                1255                1260                
Leu Pro Glu Val Glu Leu Ser Val Ser Thr Lys Lys Glu
1265                1270                1275        


<210> 205
<211> 466
<212> PRT
<213> Homo sapiens

<400> 205
Glu Lys Ala Phe Glu Pro Ala Thr Gly Arg Val Ile Ala Thr Phe Thr
 1               5                  10                  15      
Cys Ser Gly Glu Lys Glu Val Asn Leu Ala Val Gln Asn Ala Lys Ala
            20                  25                  30          
Ala Phe Lys Ile Trp Ser Gln Lys Ser Gly Met Glu Arg Cys Arg Ile
        35                  40                  45              
Leu Leu Glu Ala Ala Arg Ile Ile Arg Glu Arg Glu Asp Glu Ile Ala
    50                  55                  60                  
Thr Met Glu Cys Ile Asn Asn Gly Lys Ser Ile Phe Glu Ala Arg Leu
65                  70                  75                  80  
Asp Ile Asp Ile Ser Trp Gln Cys Leu Glu Tyr Tyr Ala Gly Leu Ala
                85                  90                  95      
Ala Ser Met Ala Gly Glu His Ile Gln Leu Pro Gly Gly Ser Phe Gly
            100                 105                 110         
Tyr Thr Arg Arg Glu Pro Leu Gly Val Cys Val Gly Ile Gly Ala Trp
        115                 120                 125             
Asn Tyr Pro Phe Gln Ile Ala Ser Trp Lys Ser Ala Pro Ala Leu Ala
    130                 135                 140                 
Cys Gly Asn Ala Met Val Phe Lys Pro Ser Pro Phe Thr Pro Val Ser
145                 150                 155                 160 
Ala Leu Leu Leu Ala Glu Ile Tyr Ser Glu Ala Gly Val Pro Pro Gly
                165                 170                 175     
Leu Phe Asn Val Val Gln Gly Gly Ala Ala Thr Gly Gln Phe Leu Cys
            180                 185                 190         
Gln His Pro Asp Val Ala Lys Val Ser Phe Thr Gly Ser Val Pro Thr
        195                 200                 205             
Gly Met Lys Ile Met Glu Met Ser Ala Lys Gly Ile Lys Pro Val Thr
    210                 215                 220                 
Leu Glu Leu Gly Gly Lys Ser Pro Leu Ile Ile Phe Ser Asp Cys Asp
225                 230                 235                 240 
Met Asn Asn Ala Val Lys Gly Ala Leu Met Ala Asn Phe Leu Thr Gln
                245                 250                 255     
Gly Gln Val Cys Cys Asn Gly Thr Arg Val Phe Val Gln Lys Glu Ile
            260                 265                 270         
Leu Asp Lys Phe Thr Glu Glu Val Val Lys Gln Thr Gln Arg Ile Lys
        275                 280                 285             
Ile Gly Asp Pro Leu Leu Glu Asp Thr Arg Met Gly Pro Leu Ile Asn
    290                 295                 300                 
Arg Pro His Leu Glu Arg Val Leu Gly Phe Val Lys Val Ala Lys Glu
305                 310                 315                 320 
Gln Gly Ala Lys Val Leu Cys Gly Gly Asp Ile Tyr Val Pro Glu Asp
                325                 330                 335     
Pro Lys Leu Lys Asp Gly Tyr Tyr Met Arg Pro Cys Val Leu Thr Asn
            340                 345                 350         
Cys Arg Asp Asp Met Thr Cys Val Lys Glu Glu Ile Phe Gly Pro Val
        355                 360                 365             
Met Ser Ile Leu Ser Phe Asp Thr Glu Ala Glu Val Leu Glu Arg Ala
    370                 375                 380                 
Asn Asp Thr Thr Phe Gly Leu Ala Ala Gly Val Phe Thr Arg Asp Ile
385                 390                 395                 400 
Gln Arg Ala His Arg Val Val Ala Glu Leu Gln Ala Gly Thr Cys Phe
                405                 410                 415     
Ile Asn Asn Tyr Asn Val Ser Pro Val Glu Leu Pro Phe Gly Gly Tyr
            420                 425                 430         
Lys Lys Ser Gly Phe Gly Arg Glu Asn Gly Arg Val Thr Ile Glu Tyr
        435                 440                 445             
Tyr Ser Gln Leu Lys Thr Val Cys Val Glu Met Gly Asp Val Glu Ser
    450                 455                 460                 
Ala Phe
465     


<210> 206
<211> 1015
<212> PRT
<213> Homo sapiens

<400> 206
Met Glu Ile His Asp Lys Lys Asp Asp Lys Asp Ser Pro Lys Lys Asn
 1               5                  10                  15      
Lys Gly Lys Glu Arg Arg Asp Leu Asp Asp Leu Lys Lys Glu Val Ala
            20                  25                  30          
Met Thr Glu His Lys Met Ser Val Glu Glu Val Cys Arg Lys Tyr Asn
        35                  40                  45              
Thr Asp Cys Val Gln Gly Leu Thr His Ser Lys Ala Gln Glu Ile Leu
    50                  55                  60                  
Ala Arg Asp Gly Pro Asn Ala Leu Thr Pro Pro Pro Thr Thr Pro Glu
65                  70                  75                  80  
Trp Val Lys Phe Cys Arg Gln Leu Phe Gly Gly Phe Ser Ile Leu Leu
                85                  90                  95      
Trp Ile Gly Ala Ile Leu Cys Phe Leu Ala Tyr Gly Ile Gln Ala Gly
            100                 105                 110         
Thr Glu Asp Asp Pro Ser Gly Asp Asn Leu Tyr Leu Gly Ile Val Leu
        115                 120                 125             
Ala Ala Val Val Ile Ile Thr Gly Cys Phe Ser Tyr Tyr Gln Glu Ala
    130                 135                 140                 
Lys Ser Ser Lys Ile Met Glu Ser Phe Lys Asn Met Val Pro Gln Gln
145                 150                 155                 160 
Ala Leu Val Ile Arg Glu Gly Glu Lys Met Gln Val Asn Ala Glu Glu
                165                 170                 175     
Val Val Val Gly Asp Leu Val Glu Ile Lys Gly Gly Asp Arg Val Pro
            180                 185                 190         
Ala Asp Leu Arg Ile Ile Ser Ala His Gly Cys Lys Val Asp Asn Ser
        195                 200                 205             
Ser Leu Thr Gly Glu Ser Glu Pro Gln Thr Arg Ser Pro Asp Cys Thr
    210                 215                 220                 
His Asp Asn Pro Leu Glu Thr Arg Asn Ile Thr Phe Phe Ser Thr Asn
225                 230                 235                 240 
Cys Val Glu Gly Thr Ala Arg Gly Val Val Val Ala Thr Gly Asp Arg
                245                 250                 255     
Thr Val Met Gly Arg Ile Ala Thr Leu Ala Ser Gly Leu Glu Val Gly
            260                 265                 270         
Lys Thr Pro Ile Ala Ile Glu Ile Glu His Phe Ile Gln Leu Ile Thr
        275                 280                 285             
Gly Val Ala Val Phe Leu Gly Val Ser Phe Phe Ile Leu Ser Leu Ile
    290                 295                 300                 
Leu Gly Tyr Thr Trp Leu Glu Ala Val Ile Phe Leu Ile Gly Ile Ile
305                 310                 315                 320 
Val Ala Asn Val Pro Glu Gly Leu Leu Ala Thr Val Thr Val Cys Leu
                325                 330                 335     
Thr Val Thr Ala Lys Arg Met Ala Arg Lys Asn Cys Leu Val Lys Asn
            340                 345                 350         
Leu Glu Ala Val Glu Thr Leu Gly Ser Thr Ser Thr Ile Cys Ser Asp
        355                 360                 365             
Lys Thr Gly Thr Leu Thr Gln Asn Arg Met Thr Val Ala His Met Trp
    370                 375                 380                 
Phe Asp Asn Gln Ile His Glu Ala Asp Thr Thr Glu Asp Gln Ser Gly
385                 390                 395                 400 
Thr Ser Phe Asp Lys Ser Ser His Thr Trp Val Ala Leu Ser His Ile
                405                 410                 415     
Ala Gly Leu Cys Asn Arg Ala Val Phe Lys Gly Gly Gln Asp Asn Met
            420                 425                 430         
Pro Val Leu Lys Arg Asp Val Ala Gly Asp Ala Ser Glu Ser Ala Leu
        435                 440                 445             
Leu Lys Cys Ile Glu Leu Ser Ser Gly Ser Val Lys Leu Met Arg Glu
    450                 455                 460                 
Arg Asn Lys Lys Val Ala Glu Ile Pro Phe Asn Ser Thr Asn Lys Tyr
465                 470                 475                 480 
Gln Leu Ser Ile His Glu Thr Glu Asp Pro Asn Asp Asn Arg Tyr Leu
                485                 490                 495     
Leu Val Met Lys Gly Ala Pro Glu Arg Ile Leu Asp Arg Cys Ser Thr
            500                 505                 510         
Ile Leu Leu Gln Gly Lys Glu Gln Pro Leu Asp Glu Glu Met Lys Glu
        515                 520                 525             
Ala Phe Gln Asn Ala Tyr Leu Glu Leu Gly Gly Leu Gly Glu Arg Val
    530                 535                 540                 
Leu Gly Phe Cys His Tyr Tyr Leu Pro Glu Glu Gln Tyr Pro Gln Gly
545                 550                 555                 560 
Phe Ala Phe Asp Cys Asp Asp Val Asn Phe Thr Thr Asp Asn Leu Cys
                565                 570                 575     
Phe Val Gly Leu Met Ser Met Ile Gly Pro Pro Arg Ala Ala Val Pro
            580                 585                 590         
Asp Ala Val Gly Lys Cys Arg Ser Ala Gly Ile Lys Val Ile Met Val
        595                 600                 605             
Thr Gly Asp His Pro Ile Thr Ala Lys Ala Ile Ala Lys Gly Val Gly
    610                 615                 620                 
Ile Ile Ser Glu Gly Asn Glu Thr Val Glu Asp Ile Ala Ala Arg Leu
625                 630                 635                 640 
Asn Ile Pro Val Ser Gln Val Asn Pro Arg Asp Ala Lys Ala Cys Val
                645                 650                 655     
Ile His Gly Thr Asp Leu Lys Asp Phe Thr Ser Glu Gln Ile Asp Glu
            660                 665                 670         
Ile Leu Gln Asn His Thr Glu Ile Val Phe Ala Arg Thr Ser Pro Gln
        675                 680                 685             
Gln Lys Leu Ile Ile Val Glu Gly Cys Gln Arg Gln Gly Ala Ile Val
    690                 695                 700                 
Ala Val Thr Gly Asp Gly Val Asn Asp Ser Pro Ala Leu Lys Lys Ala
705                 710                 715                 720 
Asp Ile Gly Val Ala Met Gly Ile Ala Gly Ser Asp Val Ser Lys Gln
                725                 730                 735     
Ala Ala Asp Met Ile Leu Leu Asp Asp Asn Phe Ala Ser Ile Val Thr
            740                 745                 750         
Gly Val Glu Glu Gly Arg Leu Ile Phe Asp Asn Leu Lys Lys Ser Ile
        755                 760                 765             
Ala Tyr Thr Leu Thr Ser Asn Ile Pro Glu Ile Thr Pro Phe Leu Leu
    770                 775                 780                 
Phe Ile Met Ala Asn Ile Pro Leu Pro Leu Gly Thr Ile Thr Ile Leu
785                 790                 795                 800 
Cys Ile Asp Leu Gly Thr Asp Met Val Pro Ala Ile Ser Leu Ala Tyr
                805                 810                 815     
Glu Ala Ala Glu Ser Asp Ile Met Lys Arg Gln Pro Arg Asn Pro Arg
            820                 825                 830         
Thr Asp Lys Leu Val Asn Glu Arg Leu Ile Ser Met Ala Tyr Gly Gln
        835                 840                 845             
Ile Gly Met Ile Gln Ala Leu Gly Gly Phe Phe Ser Tyr Phe Val Ile
    850                 855                 860                 
Leu Ala Glu Asn Gly Phe Leu Pro Gly Asn Leu Val Gly Ile Arg Leu
865                 870                 875                 880 
Asn Trp Asp Asp Arg Thr Val Asn Asp Leu Glu Asp Ser Tyr Gly Gln
                885                 890                 895     
Gln Trp Thr Tyr Glu Gln Arg Lys Val Val Glu Phe Thr Cys His Thr
            900                 905                 910         
Ala Phe Phe Val Ser Ile Val Val Val Gln Trp Ala Asp Leu Ile Ile
        915                 920                 925             
Cys Lys Thr Arg Arg Asn Ser Val Phe Gln Gln Gly Met Lys Asn Lys
    930                 935                 940                 
Ile Leu Ile Phe Gly Leu Phe Glu Glu Thr Ala Leu Ala Ala Phe Leu
945                 950                 955                 960 
Ser Tyr Cys Pro Gly Met Asp Val Ala Leu Arg Met Tyr Pro Leu Lys
                965                 970                 975     
Pro Ser Trp Trp Phe Cys Ala Ser Pro Tyr Ser Phe Leu Ile Phe Val
            980                 985                 990         
Tyr Asp Glu Ile Arg Lys Leu Ile Leu Arg Arg Asn Pro Gly Gly Trp
        995                 1000                1005            
Val Glu Lys Glu Thr Tyr Tyr
    1010                1015


<210> 207
<211> 1015
<212> PRT
<213> Homo sapiens

<400> 207
Met Glu Ile His Asp Lys Lys Asp Asp Lys Asp Ser Pro Lys Lys Asn
 1               5                  10                  15      
Lys Gly Lys Glu Arg Arg Asp Leu Asp Asp Leu Lys Lys Glu Val Ala
            20                  25                  30          
Met Thr Glu His Lys Met Ser Val Glu Glu Val Cys Arg Lys Tyr Asn
        35                  40                  45              
Thr Asp Cys Val Gln Gly Leu Thr His Ser Lys Ala Gln Glu Ile Leu
    50                  55                  60                  
Ala Arg Asp Gly Pro Asn Ala Leu Thr Pro Pro Pro Thr Thr Pro Glu
65                  70                  75                  80  
Trp Val Lys Phe Cys Arg Gln Leu Phe Gly Gly Phe Ser Ile Leu Leu
                85                  90                  95      
Trp Ile Gly Ala Ile Leu Cys Phe Leu Ala Tyr Gly Ile Gln Ala Gly
            100                 105                 110         
Thr Glu Asp Asp Pro Ser Gly Asp Asn Leu Tyr Leu Gly Ile Val Leu
        115                 120                 125             
Ala Ala Val Val Ile Ile Thr Gly Cys Phe Ser Tyr Tyr Gln Glu Ala
    130                 135                 140                 
Lys Ser Ser Lys Ile Met Glu Ser Phe Lys Asn Met Val Pro Gln Gln
145                 150                 155                 160 
Ala Leu Val Ile Arg Glu Gly Glu Lys Met Gln Val Asn Ala Glu Glu
                165                 170                 175     
Val Val Val Gly Asp Leu Val Glu Ile Lys Gly Gly Asp Arg Val Pro
            180                 185                 190         
Ala Asp Leu Arg Ile Ile Ser Ala His Gly Cys Lys Val Asp Asn Ser
        195                 200                 205             
Ser Leu Thr Gly Glu Ser Glu Pro Gln Thr Arg Ser Pro Asp Cys Thr
    210                 215                 220                 
His Asp Asn Pro Leu Glu Thr Arg Asn Ile Thr Phe Phe Ser Thr Asn
225                 230                 235                 240 
Cys Val Glu Gly Thr Ala Arg Gly Val Val Val Ala Thr Gly Asp Arg
                245                 250                 255     
Thr Val Met Gly Arg Ile Ala Thr Leu Ala Ser Gly Leu Glu Val Gly
            260                 265                 270         
Lys Thr Pro Ile Ala Ile Glu Ile Glu His Phe Ile Gln Leu Ile Thr
        275                 280                 285             
Gly Val Ala Val Phe Leu Gly Val Ser Phe Phe Ile Leu Ser Leu Ile
    290                 295                 300                 
Leu Gly Tyr Thr Trp Leu Glu Ala Val Ile Phe Leu Ile Gly Ile Ile
305                 310                 315                 320 
Val Ala Asn Val Pro Glu Gly Leu Leu Ala Thr Val Thr Val Cys Leu
                325                 330                 335     
Thr Val Thr Ala Lys Arg Met Ala Arg Lys Asn Cys Leu Val Lys Asn
            340                 345                 350         
Leu Glu Ala Val Glu Thr Leu Gly Ser Thr Ser Thr Ile Cys Ser Asp
        355                 360                 365             
Lys Thr Gly Thr Leu Thr Gln Asn Arg Met Thr Val Ala His Met Trp
    370                 375                 380                 
Phe Asp Asn Gln Ile His Glu Ala Asp Thr Thr Glu Asp Gln Ser Gly
385                 390                 395                 400 
Thr Ser Phe Asp Lys Ser Ser His Thr Trp Val Ala Leu Ser His Ile
                405                 410                 415     
Ala Gly Leu Cys Asn Arg Ala Val Phe Lys Gly Gly Gln Asp Asn Met
            420                 425                 430         
Pro Val Leu Lys Arg Asp Val Ala Gly Asp Ala Ser Glu Ser Ala Leu
        435                 440                 445             
Leu Lys Cys Ile Glu Leu Ser Ser Gly Ser Val Lys Leu Met Arg Glu
    450                 455                 460                 
Arg Asn Lys Lys Val Ala Glu Ile Pro Phe Asn Ser Thr Asn Lys Tyr
465                 470                 475                 480 
Gln Leu Ser Ile His Glu Thr Glu Asp Pro Asn Asp Asn Arg Tyr Leu
                485                 490                 495     
Leu Val Met Lys Gly Ala Pro Glu Arg Ile Leu Asp Arg Cys Ser Thr
            500                 505                 510         
Ile Leu Leu Gln Gly Lys Glu Gln Pro Leu Asp Glu Glu Met Lys Glu
        515                 520                 525             
Ala Phe Gln Asn Ala Tyr Leu Glu Leu Gly Gly Leu Gly Glu Arg Val
    530                 535                 540                 
Leu Gly Phe Cys His Tyr Tyr Leu Pro Glu Glu Gln Tyr Pro Gln Gly
545                 550                 555                 560 
Phe Ala Phe Asp Cys Asp Asp Val Asn Phe Thr Thr Asp Asn Leu Cys
                565                 570                 575     
Phe Val Gly Leu Met Ser Met Ile Gly Pro Pro Arg Ala Ala Val Pro
            580                 585                 590         
Asp Ala Val Gly Lys Cys Arg Ser Ala Gly Ile Lys Val Ile Met Val
        595                 600                 605             
Thr Gly Asp His Pro Ile Thr Ala Lys Ala Ile Ala Lys Gly Val Gly
    610                 615                 620                 
Ile Ile Ser Glu Gly Asn Glu Thr Val Glu Asp Ile Ala Ala Arg Leu
625                 630                 635                 640 
Asn Ile Pro Val Ser Gln Val Asn Pro Arg Asp Ala Lys Ala Cys Val
                645                 650                 655     
Ile His Gly Thr Asp Leu Lys Asp Phe Thr Ser Glu Gln Ile Asp Glu
            660                 665                 670         
Ile Leu Gln Asn His Thr Glu Ile Val Phe Ala Arg Thr Ser Pro Gln
        675                 680                 685             
Gln Lys Leu Ile Ile Val Glu Gly Cys Gln Arg Gln Gly Ala Ile Val
    690                 695                 700                 
Ala Val Thr Gly Asp Gly Val Asn Asp Ser Pro Ala Leu Lys Lys Ala
705                 710                 715                 720 
Asp Ile Gly Val Ala Met Gly Ile Ala Gly Ser Asp Val Ser Lys Gln
                725                 730                 735     
Ala Ala Asp Met Ile Leu Leu Asp Asp Asn Phe Ala Ser Ile Val Thr
            740                 745                 750         
Gly Val Glu Glu Gly Arg Leu Ile Phe Asp Asn Leu Lys Lys Ser Ile
        755                 760                 765             
Ala Tyr Thr Leu Thr Ser Asn Ile Pro Glu Ile Thr Pro Phe Leu Leu
    770                 775                 780                 
Phe Ile Met Ala Asn Ile Pro Leu Pro Leu Gly Thr Ile Thr Ile Leu
785                 790                 795                 800 
Cys Ile Asp Leu Gly Thr Asp Met Val Pro Ala Ile Ser Leu Ala Tyr
                805                 810                 815     
Glu Ala Ala Glu Ser Asp Ile Met Lys Arg Gln Pro Arg Asn Pro Arg
            820                 825                 830         
Thr Asp Lys Leu Val Asn Glu Arg Leu Ile Ser Met Ala Tyr Gly Gln
        835                 840                 845             
Ile Gly Met Ile Gln Ala Leu Gly Gly Phe Phe Ser Tyr Phe Val Ile
    850                 855                 860                 
Leu Ala Glu Asn Gly Phe Leu Pro Gly Asn Leu Val Gly Ile Arg Leu
865                 870                 875                 880 
Asn Trp Asp Asp Arg Thr Val Asn Asp Leu Glu Asp Ser Tyr Gly Gln
                885                 890                 895     
Gln Trp Thr Tyr Glu Gln Arg Lys Val Val Glu Phe Thr Cys His Thr
            900                 905                 910         
Ala Phe Phe Val Ser Ile Val Val Val Gln Trp Ala Asp Leu Ile Ile
        915                 920                 925             
Cys Lys Thr Arg Arg Asn Ser Val Phe Gln Gln Gly Met Lys Asn Lys
    930                 935                 940                 
Ile Leu Ile Phe Gly Leu Phe Glu Glu Thr Ala Leu Ala Ala Phe Leu
945                 950                 955                 960 
Ser Tyr Cys Pro Gly Met Asp Val Ala Leu Arg Met Tyr Pro Leu Lys
                965                 970                 975     
Pro Ser Trp Trp Phe Cys Ala Ser Pro Tyr Ser Phe Leu Ile Phe Val
            980                 985                 990         
Tyr Asp Glu Ile Arg Lys Leu Ile Leu Arg Arg Asn Pro Gly Gly Trp
        995                 1000                1005            
Val Glu Lys Glu Thr Tyr Tyr
    1010                1015


<210> 208
<211> 348
<212> PRT
<213> Homo sapiens

<400> 208
Asn Gly Thr Ala Ser Ser Phe Cys Leu Asp Ser Thr Ala Cys Lys Ile
 1               5                  10                  15      
Thr Ile Thr Val Val Leu Ala Val Leu Ile Leu Ile Thr Val Ala Gly
            20                  25                  30          
Asn Val Val Val Cys Leu Ala Val Gly Leu Asn Arg Arg Leu Arg Asn
        35                  40                  45              
Leu Thr Asn Cys Phe Ile Val Ser Leu Ala Ile Thr Asp Leu Leu Leu
    50                  55                  60                  
Gly Leu Leu Val Leu Pro Phe Ser Ala Ile Tyr Gln Leu Ser Cys Lys
65                  70                  75                  80  
Trp Ser Phe Gly Lys Val Phe Cys Asn Ile Tyr Thr Ser Leu Asp Val
                85                  90                  95      
Met Leu Cys Thr Ala Ser Ile Leu Asn Leu Phe Met Ile Ser Leu Asp
            100                 105                 110         
Arg Tyr Cys Ala Val Met Asp Pro Leu Arg Tyr Pro Val Leu Val Thr
        115                 120                 125             
Pro Ala Arg Val Ala Ile Ser Leu Val Leu Ile Trp Val Ile Ser Ile
    130                 135                 140                 
Thr Leu Ser Phe Leu Ser Ile His Leu Gly Trp Asn Ser Arg Asn Glu
145                 150                 155                 160 
Thr Ser Lys Gly Asn His Thr Thr Ser Lys Cys Asn Val Gln Val Asn
                165                 170                 175     
Glu Val Tyr Gly Leu Val Asp Gly Leu Val Thr Phe Tyr Leu Pro Leu
            180                 185                 190         
Leu Ile Met Cys Ile Thr Tyr Tyr Arg Ile Phe Arg Val Ala Arg Asp
        195                 200                 205             
Gln Ala Lys Arg Ile Asp His Ile Ser Ser Trp Lys Ala Ala Thr Ile
    210                 215                 220                 
Arg Glu His Arg Ala Thr Val Thr Leu Ala Ala Val Met Gly Ala Phe
225                 230                 235                 240 
Ile Ile Cys Trp Phe Pro Tyr Phe Thr Ala Phe Val Tyr Arg Gly Leu
                245                 250                 255     
Arg Gly Asp Asp Ala Ile Asn Glu Met Leu Glu Ala Ile Val Leu Trp
            260                 265                 270         
Leu Gly Tyr Ala Asn Ser Ala Leu Asn Pro Ile Leu Tyr Ala Ala Leu
        275                 280                 285             
Asn Arg Asp Phe Arg Thr Gly Tyr Gln Gln Leu Phe Cys Cys Arg Leu
    290                 295                 300                 
Ala Asn Arg Asn Ser His Lys Thr Ser Leu Arg Ser Asn Ala Ser Gln
305                 310                 315                 320 
Leu Ser Arg Thr Gln Ser Arg Glu Pro Arg Gln Gln Glu Glu Lys Pro
                325                 330                 335     
Leu Lys Leu Gln Val Trp Ser Gly Thr Glu Val Thr
            340                 345             


<210> 209
<211> 962
<212> PRT
<213> Homo sapiens

<400> 209
Met Ala Gly Leu Trp Arg Arg Ala Leu Ala Thr Cys Asp Cys Gly Glu
 1               5                  10                  15      
Arg Arg Gly Ala Gly Cys Cys Gly Gly Arg Cys Trp Pro Arg Arg Gly
            20                  25                  30          
Ala Gly Ser His Cys Ser Arg Ser Val Val Ala Pro Arg Pro Ala Asp
        35                  40                  45              
Leu Arg Arg Leu Ser Ser Leu Gly Thr Val Gly Arg Gly Pro Ala Ile
    50                  55                  60                  
Gly Gly Gln Cys Gly Gly Phe Trp Glu Ala Ser Ser Arg Gly Gly Gly
65                  70                  75                  80  
Ala Phe Ser Gly Gly Glu Asp Ala Ser Glu Gly Gly Ala Glu Glu Gly
                85                  90                  95      
Ala Gly Gly Ala Gly Gly Ser Ala Gly Ala Gly Glu Gly Pro Val Ile
            100                 105                 110         
Thr Ala Leu Thr Pro Met Thr Ile Pro Asp Val Phe Pro His Leu Pro
        115                 120                 125             
Leu Ile Ala Ile Thr Arg Asn Pro Val Phe Pro Arg Phe Ile Lys Ile
    130                 135                 140                 
Ile Glu Val Lys Asn Lys Lys Leu Val Glu Leu Leu Arg Arg Lys Val
145                 150                 155                 160 
Arg Leu Ala Gln Pro Tyr Val Gly Val Phe Leu Lys Arg Asp Asp Ser
                165                 170                 175     
Asn Glu Ser Asp Val Val Glu Ser Leu Asp Glu Ile Tyr His Thr Gly
            180                 185                 190         
Thr Phe Ala Gln Ile His Glu Met Gln Asp Leu Gly Asp Lys Leu Arg
        195                 200                 205             
Met Ile Val Met Gly His Arg Arg Val His Ile Ser Arg Gln Leu Glu
    210                 215                 220                 
Val Glu Pro Glu Glu Pro Glu Ala Glu Asn Lys His Lys Pro Arg Arg
225                 230                 235                 240 
Lys Ser Lys Arg Gly Lys Lys Glu Ala Glu Asp Glu Leu Ser Ala Arg
                245                 250                 255     
His Pro Ala Asp Val Ala Met Glu Pro Thr Pro Glu Leu Pro Ala Glu
            260                 265                 270         
Val Leu Met Val Glu Val Glu Asn Val Val His Glu Asp Phe Gln Val
        275                 280                 285             
Thr Glu Glu Val Lys Ala Leu Thr Ala Glu Ile Val Lys Thr Ile Arg
    290                 295                 300                 
Asp Ile Ile Ala Leu Asn Pro Leu Tyr Arg Glu Ser Val Leu Gln Met
305                 310                 315                 320 
Met Gln Ala Gly Gln Arg Val Val Asp Asn Pro Ile Tyr Leu Ser Asp
                325                 330                 335     
Met Gly Ala Ala Leu Thr Gly Ala Glu Ser His Glu Leu Gln Asp Val
            340                 345                 350         
Leu Glu Glu Thr Asn Ile Pro Lys Arg Leu Tyr Lys Ala Leu Ser Leu
        355                 360                 365             
Leu Lys Lys Glu Phe Glu Leu Ser Lys Leu Gln Gln Arg Leu Gly Arg
    370                 375                 380                 
Glu Val Glu Glu Lys Ile Lys Gln Thr His Arg Lys Tyr Leu Leu Gln
385                 390                 395                 400 
Glu Gln Leu Lys Ile Ile Lys Lys Glu Leu Gly Leu Glu Lys Asp Asp
                405                 410                 415     
Lys Asp Ala Ile Glu Glu Lys Phe Arg Glu Arg Leu Lys Glu Leu Val
            420                 425                 430         
Val Pro Lys His Val Met Asp Val Val Asp Glu Glu Leu Ser Lys Leu
        435                 440                 445             
Gly Leu Leu Asp Asn His Ser Ser Glu Phe Asp Val Thr Arg Asn Tyr
    450                 455                 460                 
Leu Asp Trp Leu Thr Ser Ile Pro Trp Gly Lys Tyr Ser Asn Glu Asn
465                 470                 475                 480 
Leu Asp Leu Ala Arg Ala Gln Ala Val Leu Glu Glu Asp His Tyr Gly
                485                 490                 495     
Met Glu Asp Val Lys Lys Arg Ile Leu Glu Phe Ile Ala Val Ser Gln
            500                 505                 510         
Leu Arg Gly Ser Thr Gln Gly Lys Ile Leu Cys Phe Tyr Gly Pro Pro
        515                 520                 525             
Gly Val Gly Lys Thr Ser Ile Ala Arg Ser Ile Ala Arg Ala Leu Asn
    530                 535                 540                 
Arg Glu Tyr Phe Arg Phe Ser Val Gly Gly Met Thr Asp Val Thr Glu
545                 550                 555                 560 
Ile Lys Gly His Arg Arg Thr Tyr Val Gly Ala Met Pro Gly Lys Ile
                565                 570                 575     
Ile Gln Cys Leu Lys Lys Thr Lys Thr Glu Asn Pro Leu Ile Leu Ile
            580                 585                 590         
Asp Glu Val Asp Lys Ile Gly Arg Gly Tyr Gln Gly Asp Pro Ser Ser
        595                 600                 605             
Ala Leu Leu Glu Leu Leu Asp Pro Glu Gln Asn Ala Asn Phe Leu Asp
    610                 615                 620                 
His Tyr Leu Asp Val Pro Val Asp Leu Ser Lys Val Leu Phe Ile Cys
625                 630                 635                 640 
Thr Ala Asn Val Thr Asp Thr Ile Pro Glu Pro Leu Arg Asp Arg Met
                645                 650                 655     
Glu Met Ile Asn Val Ser Gly Tyr Val Ala Gln Glu Lys Leu Ala Ile
            660                 665                 670         
Ala Glu Arg Tyr Leu Val Pro Gln Ala Arg Ala Leu Cys Gly Leu Asp
        675                 680                 685             
Glu Ser Lys Ala Lys Leu Ser Ser Asp Val Leu Thr Leu Leu Ile Lys
    690                 695                 700                 
Gln Tyr Cys Arg Glu Ser Gly Val Arg Asn Leu Gln Lys Gln Val Glu
705                 710                 715                 720 
Lys Val Leu Arg Lys Ser Ala Tyr Lys Ile Val Ser Gly Glu Ala Glu
                725                 730                 735     
Ser Val Glu Val Thr Pro Glu Asn Leu Gln Asp Phe Val Gly Lys Pro
            740                 745                 750         
Val Phe Thr Val Glu Arg Met Tyr Asp Val Thr Pro Pro Gly Val Val
        755                 760                 765             
Met Gly Leu Ala Trp Thr Ala Met Gly Gly Ser Thr Leu Phe Val Glu
    770                 775                 780                 
Thr Ser Leu Arg Arg Pro Gln Asp Lys Asp Ala Lys Gly Asp Lys Asp
785                 790                 795                 800 
Gly Ser Leu Glu Val Thr Gly Gln Leu Gly Glu Val Met Lys Glu Ser
                805                 810                 815     
Ala Arg Ile Ala Tyr Thr Phe Ala Arg Ala Phe Leu Met Gln His Ala
            820                 825                 830         
Pro Ala Asn Asp Tyr Leu Val Thr Ser His Ile His Pro His Val Pro
        835                 840                 845             
Glu Gly Ala Thr Pro Lys Asp Gly Pro Ser Ala Gly Cys Ala Ile Val
    850                 855                 860                 
Thr Ala Leu Leu Ser Leu Ala Met Gly Arg Pro Val Arg Gln Asn Leu
865                 870                 875                 880 
Ala Met Thr Gly Glu Val Ser Leu Thr Gly Lys Ile Leu Pro Val Gly
                885                 890                 895     
Gly Ile Lys Glu Lys Thr Ile Ala Ala Lys Arg Ala Gly Val Thr Cys
            900                 905                 910         
Ile Val Leu Pro Ala Glu Asn Lys Lys Asp Phe Tyr Asp Leu Ala Ala
        915                 920                 925             
Phe Ile Thr Glu Gly Leu Glu Val His Phe Val Glu His Tyr Arg Glu
    930                 935                 940                 
Ile Phe Asp Ile Ala Phe Pro Asp Glu Gln Ala Glu Ala Leu Ala Val
945                 950                 955                 960 
Glu Arg
        


<210> 210
<211> 150
<212> PRT
<213> Homo sapiens

<400> 210
Lys Ala Ile Val Ala Gly Asp Gln Asn Val Glu Tyr Lys Gly Thr Val
 1               5                  10                  15      
Trp His Lys Asp Cys Phe Thr Cys Ser Asn Cys Lys Gln Val Ile Gly
            20                  25                  30          
Thr Gly Ser Phe Phe Pro Lys Gly Glu Asp Phe Tyr Cys Val Thr Cys
        35                  40                  45              
His Glu Thr Lys Leu Ala Lys His Cys Val Lys Cys Asn Lys Ala Ile
    50                  55                  60                  
Thr Ser Gly Gly Ile Thr Tyr Gln Asp Gln Pro Trp His Ala Asp Cys
65                  70                  75                  80  
Phe Val Cys Val Thr Cys Ser Lys Lys Leu Ala Gly Gln Arg Phe Thr
                85                  90                  95      
Ala Val Glu Asp Gln Tyr Tyr Cys Val Asp Cys Tyr Lys Asn Phe Val
            100                 105                 110         
Ala Lys Lys Cys Ala Gly Cys Lys Asn Pro Ile Thr Gly Phe Gly Lys
        115                 120                 125             
Gly Ser Ser Val Val Ala Tyr Glu Gly Gln Ser Trp His Asp Tyr Cys
    130                 135                 140                 
Phe His Cys Lys Lys Cys
145                 150 


<210> 211
<211> 397
<212> PRT
<213> Homo sapiens

<400> 211
Ala Arg Gly Leu His Phe Val Lys Phe Ala Ile Asp Ser Asp Gln Leu
 1               5                  10                  15      
His Gln Leu Trp Glu Lys Asp Gln Leu Asn Met Ala Lys Asn Thr Trp
            20                  25                  30          
Pro Ile Leu Lys Gly Phe Gln Glu Gly Pro Leu Asn Phe Ala Pro Thr
        35                  40                  45              
Phe Lys Phe Asp Val Gly Thr Asn Lys Tyr Asp Thr Ser Ala Lys Lys
    50                  55                  60                  
Arg Lys Pro Ala Trp Thr Asp Arg Ile Leu Trp Lys Val Lys Ala Pro
65                  70                  75                  80  
Gly Gly Gly Pro Ser Pro Ser Gly Arg Lys Ser His Arg Leu Gln Val
                85                  90                  95      
Thr Gln His Ser Tyr Arg Ser His Met Glu Tyr Thr Val Ser Asp His
            100                 105                 110         
Lys Pro Val Ala Ala Gln Phe Leu Leu Gln Phe Ala Phe Arg Asp Asp
        115                 120                 125             
Met Pro Leu Val Arg Leu Glu Val Ala Asp Glu Trp Val Arg Pro Glu
    130                 135                 140                 
Gln Ala Val Val Arg Tyr Arg Met Glu Thr Val Phe Ala Arg Ser Ser
145                 150                 155                 160 
Trp Asp Trp Ile Gly Leu Tyr Arg Val Gly Phe Arg His Cys Lys Asp
                165                 170                 175     
Tyr Val Ala Tyr Val Trp Ala Lys His Glu Asp Val Asp Gly Asn Thr
            180                 185                 190         
Tyr Gln Val Thr Phe Ser Glu Glu Ser Leu Pro Lys Gly His Gly Asp
        195                 200                 205             
Phe Ile Leu Gly Tyr Tyr Ser His Asn His Ser Ile Leu Ile Gly Ile
    210                 215                 220                 
Thr Glu Pro Phe Gln Ile Ser Leu Pro Ser Ser Glu Leu Ala Ser Ser
225                 230                 235                 240 
Ser Thr Asp Ser Ser Gly Thr Ser Ser Glu Gly Glu Asp Asp Ser Thr
                245                 250                 255     
Leu Glu Leu Leu Ala Pro Lys Ser Arg Ser Pro Ser Pro Gly Lys Ser
            260                 265                 270         
Lys Arg His Arg Ser Arg Ser Pro Gly Leu Ala Arg Phe Pro Gly Leu
        275                 280                 285             
Ala Leu Arg Pro Ser Ser Arg Glu Arg Arg Gly Ala Ser Arg Ser Pro
    290                 295                 300                 
Ser Pro Gln Ser Arg Arg Leu Ser Arg Val Ala Pro Asp Arg Ser Ser
305                 310                 315                 320 
Asn Gly Ser Ser Arg Gly Ser Ser Glu Glu Gly Pro Ser Gly Leu Pro
                325                 330                 335     
Gly Pro Trp Ala Phe Pro Pro Ala Val Pro Arg Ser Leu Gly Leu Leu
            340                 345                 350         
Pro Ala Leu Arg Leu Glu Thr Val Asp Pro Gly Gly Gly Gly Ser Trp
        355                 360                 365             
Gly Pro Asp Arg Glu Ala Leu Ala Pro Asn Ser Leu Ser Pro Ser Pro
    370                 375                 380                 
Gln Gly His Arg Gly Leu Glu Glu Gly Gly Leu Gly Pro
385                 390                 395         


<210> 212
<211> 466
<212> PRT
<213> Homo sapiens

<400> 212
Glu Trp Arg Arg Gly Glu Gly Arg Asp Glu Asp Arg Ser His Arg Arg
 1               5                  10                  15      
Asp Glu Glu Arg Pro Arg Arg Leu Gly Asp Asp Glu Asp Arg Glu Pro
            20                  25                  30          
Ser Leu Arg Pro Asp Asp Asp Arg Val Pro Arg Arg Gly Met Asp Asp
        35                  40                  45              
Asp Arg Gly Pro Arg Arg Gly Pro Glu Glu Asp Arg Phe Ser Arg Arg
    50                  55                  60                  
Gly Ala Asp Asp Asp Arg Pro Ser Trp Arg Asn Thr Asp Asp Asp Arg
65                  70                  75                  80  
Pro Pro Arg Arg Ile Ala Asp Glu Asp Arg Gly Asn Trp Arg His Ala
                85                  90                  95      
Asp Asp Asp Arg Pro Pro Arg Arg Gly Leu Asp Glu Asp Arg Gly Ser
            100                 105                 110         
Trp Arg Thr Ala Asp Glu Asp Arg Gly Pro Arg Arg Gly Met Asp Asp
        115                 120                 125             
Asp Arg Gly Pro Arg Arg Gly Gly Ala Asp Asp Glu Arg Ser Ser Trp
    130                 135                 140                 
Arg Asn Ala Asp Asp Asp Arg Gly Pro Arg Arg Gly Leu Asp Asp Asp
145                 150                 155                 160 
Arg Gly Pro Arg Arg Gly Met Asp Asp Asp Arg Gly Pro Arg Arg Gly
                165                 170                 175     
Met Asp Asp Asp Arg Gly Pro Arg Arg Gly Met Asp Asp Asp Arg Gly
            180                 185                 190         
Pro Arg Arg Gly Leu Asp Asp Asp Arg Gly Pro Trp Arg Asn Ala Asp
        195                 200                 205             
Asp Asp Arg Ile Pro Arg Arg Gly Ala Glu Asp Asp Arg Gly Pro Trp
    210                 215                 220                 
Arg Asn Met Asp Asp Asp Arg Leu Ser Arg Arg Ala Asp Asp Asp Arg
225                 230                 235                 240 
Phe Pro Arg Arg Gly Asp Asp Ser Arg Pro Gly Pro Trp Arg Pro Leu
                245                 250                 255     
Val Lys Pro Gly Gly Trp Arg Glu Lys Glu Lys Ala Arg Glu Glu Ser
            260                 265                 270         
Trp Gly Pro Pro Arg Glu Ser Arg Pro Ser Glu Glu Arg Glu Trp Asp
        275                 280                 285             
Arg Glu Lys Glu Arg Asp Arg Asp Asn Gln Asp Arg Glu Glu Asn Asp
    290                 295                 300                 
Lys Asp Pro Glu Arg Glu Arg Asp Arg Glu Arg Asp Val Asp Arg Glu
305                 310                 315                 320 
Asp Arg Phe Arg Arg Pro Arg Asp Glu Gly Gly Trp Arg Arg Gly Pro
                325                 330                 335     
Ala Glu Glu Ser Ser Ser Trp Arg Asp Ser Ser Arg Arg Asp Asp Arg
            340                 345                 350         
Asp Arg Asp Asp Arg Arg Arg Glu Arg Asp Asp Arg Arg Asp Leu Arg
        355                 360                 365             
Glu Arg Arg Asp Leu Arg Asp Asp Arg Asp Arg Arg Gly Pro Pro Leu
    370                 375                 380                 
Arg Ser Glu Arg Glu Glu Val Ser Ser Trp Arg Arg Ala Asp Asp Arg
385                 390                 395                 400 
Lys Asp Asp Arg Val Glu Glu Arg Asp Pro Pro Arg Arg Val Pro Pro
                405                 410                 415     
Pro Ala Leu Ser Arg Asp Arg Glu Arg Asp Arg Asp Arg Glu Arg Glu
            420                 425                 430         
Gly Glu Lys Glu Lys Ala Ser Trp Arg Ala Glu Lys Asp Arg Glu Ser
        435                 440                 445             
Leu Arg Arg Thr Lys Asn Glu Thr Asp Glu Asp Gly Trp Thr Thr Val
    450                 455                 460                 
Arg Arg
465     


<210> 213
<211> 469
<212> PRT
<213> Homo sapiens

<400> 213
Met Ser Gln Ala Tyr Ser Ser Ser Gln Arg Val Ser Ser Tyr Arg Arg
 1               5                  10                  15      
Thr Phe Gly Gly Ala Pro Gly Phe Pro Leu Gly Ser Pro Leu Ser Ser
            20                  25                  30          
Pro Val Phe Pro Arg Ala Gly Phe Gly Ser Lys Gly Ser Ser Ser Ser
        35                  40                  45              
Val Thr Ser Arg Val Tyr Gln Val Ser Arg Thr Ser Gly Gly Ala Gly
    50                  55                  60                  
Gly Leu Gly Ser Leu Arg Ala Ser Arg Leu Gly Thr Thr Arg Thr Pro
65                  70                  75                  80  
Ser Ser Tyr Gly Ala Gly Glu Leu Leu Asp Phe Ser Leu Ala Asp Ala
                85                  90                  95      
Val Asn Gln Glu Phe Leu Thr Thr Arg Thr Asn Glu Lys Val Glu Leu
            100                 105                 110         
Gln Glu Leu Asn Asp Arg Phe Ala Asn Tyr Ile Glu Lys Val Arg Phe
        115                 120                 125             
Leu Glu Gln Gln Asn Ala Leu Ala Ala Glu Val Asn Arg Leu Lys Gly
    130                 135                 140                 
Arg Glu Pro Thr Arg Val Ala Glu Leu Tyr Glu Glu Glu Leu Arg Glu
145                 150                 155                 160 
Leu Arg Arg Gln Val Glu Val Leu Thr Asn Gln Arg Ala Arg Val Asp
                165                 170                 175     
Val Glu Arg Asp Asn Leu Leu Asp Asp Leu Gln Arg Leu Lys Ala Lys
            180                 185                 190         
Leu Gln Glu Glu Ile Gln Leu Lys Glu Glu Ala Glu Asn Asn Leu Ala
        195                 200                 205             
Ala Phe Arg Ala Asp Val Asp Ala Ala Thr Leu Ala Arg Ile Asp Leu
    210                 215                 220                 
Glu Arg Arg Ile Glu Ser Leu Asn Glu Glu Ile Ala Phe Leu Lys Lys
225                 230                 235                 240 
Val His Glu Glu Glu Ile Arg Glu Leu Gln Ala Gln Leu Gln Glu Gln
                245                 250                 255     
Gln Val Gln Val Glu Met Asp Met Ser Lys Pro Asp Leu Thr Ala Ala
            260                 265                 270         
Leu Arg Asp Ile Arg Ala Gln Tyr Glu Thr Ile Ala Ala Lys Asn Ile
        275                 280                 285             
Ser Glu Ala Glu Glu Trp Tyr Lys Ser Lys Val Ser Asp Leu Thr Gln
    290                 295                 300                 
Ala Ala Asn Lys Asn Asn Asp Ala Leu Arg Gln Ala Lys Gln Glu Met
305                 310                 315                 320 
Met Glu Tyr Arg His Gln Ile Gln Ser Tyr Thr Cys Glu Ile Asp Ala
                325                 330                 335     
Leu Lys Gly Thr Asn Asp Ser Leu Met Arg Gln Met Arg Glu Leu Glu
            340                 345                 350         
Asp Arg Phe Ala Ser Glu Ala Ser Gly Tyr Gln Asp Asn Ile Ala Arg
        355                 360                 365             
Leu Glu Glu Glu Ile Arg His Leu Lys Asp Glu Met Ala Arg His Leu
    370                 375                 380                 
Arg Glu Tyr Gln Asp Leu Leu Asn Val Lys Met Ala Leu Asp Val Glu
385                 390                 395                 400 
Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Ser Arg Ile Asn
                405                 410                 415     
Leu Pro Ile Gln Thr Tyr Ser Ala Leu Asn Phe Arg Glu Thr Ser Pro
            420                 425                 430         
Glu Gln Arg Gly Ser Glu Val His Thr Lys Lys Thr Val Met Ile Lys
        435                 440                 445             
Thr Ile Glu Thr Arg Asp Gly Glu Val Val Ser Glu Ala Thr Gln Gln
    450                 455                 460                 
Gln His Glu Val Leu
465                 


<210> 214
<211> 2412
<212> PRT
<213> Homo sapiens

<400> 214
Asp Leu Ile Leu Pro Thr Ile Gln Lys Ser Leu Leu Arg Ser Pro Glu
 1               5                  10                  15      
Asn Val Ile Glu Thr Ile Ser Ser Leu Leu Ala Ser Val Thr Leu Asp
            20                  25                  30          
Leu Ser Gln Tyr Ala Met Asp Ile Val Lys Gly Leu Ala Gly His Leu
        35                  40                  45              
Lys Ser Asn Ser Pro Arg Leu Met Asp Glu Ala Val Leu Ala Leu Arg
    50                  55                  60                  
Asn Leu Ala Arg Gln Cys Ser Asp Ser Ser Ala Met Glu Ser Leu Thr
65                  70                  75                  80  
Lys His Leu Phe Ala Ile Leu Gly Gly Ser Glu Gly Lys Leu Thr Val
                85                  90                  95      
Val Ala Gln Lys Met Ser Val Leu Ser Gly Ile Gly Ser Val Ser His
            100                 105                 110         
His Val Val Ser Gly Pro Ser Ser Gln Val Leu Asn Gly Ile Val Ala
        115                 120                 125             
Glu Leu Phe Ile Pro Phe Leu Gln Gln Glu Val His Glu Gly Thr Leu
    130                 135                 140                 
Val His Ala Val Ser Val Leu Ala Leu Trp Cys Asn Arg Phe Thr Met
145                 150                 155                 160 
Glu Val Pro Lys Lys Leu Thr Glu Trp Phe Lys Lys Ala Phe Ser Leu
                165                 170                 175     
Lys Thr Ser Thr Ser Ala Val Arg His Ala Tyr Leu Gln Cys Met Leu
            180                 185                 190         
Ala Ser Tyr Arg Gly Asp Thr Leu Leu Gln Ala Leu Asp Leu Leu Pro
        195                 200                 205             
Leu Leu Ile Gln Thr Val Glu Lys Ala Ala Ser Gln Ser Thr Gln Val
    210                 215                 220                 
Pro Thr Ile Thr Glu Gly Val Ala Ala Ala Leu Leu Leu Leu Lys Leu
225                 230                 235                 240 
Ser Val Ala Asp Ser Gln Ala Glu Ala Lys Leu Ser Ser Phe Trp Gln
                245                 250                 255     
Leu Ile Val Asp Glu Lys Lys Gln Val Phe Thr Ser Glu Lys Phe Leu
            260                 265                 270         
Val Met Ala Ser Glu Asp Ala Leu Cys Thr Val Leu His Leu Thr Glu
        275                 280                 285             
Arg Leu Phe Leu Asp His Pro His Arg Leu Thr Gly Asn Lys Val Gln
    290                 295                 300                 
Gln Tyr His Arg Ala Leu Val Ala Val Leu Leu Ser Arg Thr Trp His
305                 310                 315                 320 
Val Arg Arg Gln Ala Gln Gln Thr Val Arg Lys Leu Leu Ser Ser Leu
                325                 330                 335     
Gly Gly Phe Lys Leu Ala His Gly Leu Leu Glu Glu Leu Lys Thr Val
            340                 345                 350         
Leu Ser Ser His Lys Val Leu Pro Leu Glu Ala Leu Val Thr Asp Ala
        355                 360                 365             
Gly Glu Val Thr Glu Ala Gly Lys Ala Tyr Val Pro Pro Arg Val Leu
    370                 375                 380                 
Gln Glu Ala Leu Cys Val Ile Ser Gly Val Pro Gly Leu Lys Gly Asp
385                 390                 395                 400 
Val Thr Asp Thr Glu Gln Leu Ala Gln Glu Met Leu Ile Ile Ser His
                405                 410                 415     
His Pro Ser Leu Val Ala Val Gln Ser Gly Leu Trp Pro Ala Leu Leu
            420                 425                 430         
Ala Arg Met Lys Ile Asp Pro Glu Ala Phe Ile Thr Arg His Leu Asp
        435                 440                 445             
Gln Ile Ile Pro Arg Met Thr Thr Gln Ser Pro Leu Asn Gln Ser Ser
    450                 455                 460                 
Met Asn Ala Met Gly Ser Leu Ser Val Leu Ser Pro Asp Arg Val Leu
465                 470                 475                 480 
Pro Gln Leu Ile Ser Thr Ile Thr Ala Ser Val Gln Asn Pro Ala Leu
                485                 490                 495     
Arg Leu Val Thr Arg Glu Glu Phe Ala Ile Met Gln Thr Pro Ala Gly
            500                 505                 510         
Glu Leu Tyr Asp Lys Ser Ile Ile Gln Ser Ala Gln Gln Asp Ser Ile
        515                 520                 525             
Lys Lys Ala Asn Met Lys Arg Glu Asn Lys Ala Tyr Ser Phe Lys Glu
    530                 535                 540                 
Gln Ile Ile Glu Leu Glu Leu Lys Glu Glu Ile Lys Lys Lys Lys Gly
545                 550                 555                 560 
Ile Lys Glu Glu Val Gln Leu Thr Ser Lys Gln Lys Glu Met Leu Gln
                565                 570                 575     
Ala Gln Leu Asp Arg Glu Ala Gln Val Arg Arg Arg Leu Gln Glu Leu
            580                 585                 590         
Asp Gly Glu Leu Glu Ala Ala Leu Gly Leu Leu Asp Ile Ile Leu Ala
        595                 600                 605             
Lys Asn Pro Ser Gly Leu Thr Gln Tyr Ile Pro Val Leu Val Asp Ser
    610                 615                 620                 
Phe Leu Pro Leu Leu Lys Ser Pro Leu Ala Ala Pro Arg Ile Lys Asn
625                 630                 635                 640 
Pro Phe Leu Ser Leu Ala Ala Cys Val Met Pro Ser Arg Leu Lys Ala
                645                 650                 655     
Leu Gly Thr Leu Val Ser His Val Thr Leu Arg Leu Leu Lys Pro Glu
            660                 665                 670         
Cys Val Leu Asp Lys Ser Trp Cys Gln Glu Glu Leu Ser Val Ala Val
        675                 680                 685             
Lys Arg Ala Val Met Leu Leu His Thr His Thr Ile Thr Ser Arg Val
    690                 695                 700                 
Gly Lys Gly Glu Pro Gly Ala Ala Pro Leu Ser Ala Pro Ala Phe Ser
705                 710                 715                 720 
Leu Val Phe Pro Phe Leu Lys Met Val Leu Thr Glu Met Pro His His
                725                 730                 735     
Ser Glu Glu Glu Glu Glu Trp Met Ala Gln Ile Leu Gln Ile Leu Thr
            740                 745                 750         
Val Gln Ala Gln Leu Arg Ala Ser Pro Asn Thr Pro Pro Gly Arg Val
        755                 760                 765             
Asp Glu Asn Gly Pro Glu Leu Leu Pro Arg Val Ala Met Leu Arg Leu
    770                 775                 780                 
Leu Thr Trp Val Ile Gly Thr Gly Ser Pro Arg Leu Gln Val Leu Ala
785                 790                 795                 800 
Ser Asp Thr Leu Thr Thr Leu Cys Ala Ser Ser Ser Gly Asp Asp Gly
                805                 810                 815     
Cys Ala Phe Ala Glu Gln Glu Glu Val Asp Val Leu Leu Cys Ala Leu
            820                 825                 830         
Gln Ser Pro Cys Ala Ser Val Arg Glu Thr Val Leu Arg Gly Leu Met
        835                 840                 845             
Glu Leu His Met Val Leu Pro Ala Pro Asp Thr Asp Glu Lys Asn Gly
    850                 855                 860                 
Leu Asn Leu Leu Arg Arg Leu Trp Val Val Lys Phe Asp Lys Glu Glu
865                 870                 875                 880 
Glu Ile Arg Lys Leu Ala Glu Arg Leu Trp Ser Met Met Gly Leu Asp
                885                 890                 895     
Leu Gln Pro Asp Leu Cys Ser Leu Leu Ile Asp Asp Val Ile Tyr His
            900                 905                 910         
Glu Ala Ala Val Arg Gln Ala Gly Ala Glu Ala Leu Ser Gln Ala Val
        915                 920                 925             
Ala Arg Tyr Gln Arg Gln Ala Ala Glu Val Met Gly Arg Leu Met Glu
    930                 935                 940                 
Ile Tyr Gln Glu Lys Leu Tyr Arg Pro Pro Pro Val Leu Asp Ala Leu
945                 950                 955                 960 
Gly Arg Val Ile Ser Glu Ser Pro Pro Asp Gln Trp Glu Ala Arg Cys
                965                 970                 975     
Gly Leu Ala Leu Ala Leu Asn Lys Leu Ser Gln Tyr Leu Asp Ser Ser
            980                 985                 990         
Gln Val Lys Pro Leu Phe Gln Phe Phe Val Pro Asp Ala Leu Asn Asp
        995                 1000                1005            
Arg His Pro Asp Val Arg Lys Cys Met Leu Asp Ala Ala Leu Ala Thr
    1010                1015                1020                
Leu Asn Thr His Gly Lys Glu Asn Val Asn Ser Leu Leu Pro Val Phe
1025                1030                1035                1040
Glu Glu Phe Leu Lys Asn Ala Pro Asn Asp Ala Ser Tyr Asp Ala Val
                1045                1050                1055    
Arg Gln Ser Val Val Val Leu Met Gly Ser Leu Ala Lys His Leu Asp
            1060                1065                1070        
Lys Ser Asp Pro Lys Val Lys Pro Ile Val Ala Lys Leu Ile Ala Ala
        1075                1080                1085            
Leu Ser Thr Pro Ser Gln Gln Val Gln Glu Ser Val Ala Ser Cys Leu
    1090                1095                1100                
Pro Pro Leu Val Pro Ala Ile Lys Glu Asp Ala Gly Gly Met Ile Gln
1105                1110                1115                1120
Arg Leu Met Gln Gln Leu Leu Glu Ser Asp Lys Tyr Ala Glu Arg Lys
                1125                1130                1135    
Gly Ala Ala Tyr Gly Leu Ala Gly Leu Val Lys Gly Leu Gly Ile Leu
            1140                1145                1150        
Ser Leu Lys Gln Gln Glu Met Met Ala Ala Leu Thr Asp Ala Ile Gln
        1155                1160                1165            
Asp Lys Lys Asn Phe Arg Arg Arg Glu Gly Ala Leu Phe Ala Phe Glu
    1170                1175                1180                
Met Leu Cys Thr Met Leu Gly Lys Leu Phe Glu Pro Tyr Val Val His
1185                1190                1195                1200
Val Leu Pro His Leu Leu Leu Cys Phe Gly Asp Gly Asn Gln Tyr Val
                1205                1210                1215    
Arg Glu Ala Ala Asp Asp Cys Ala Lys Ala Val Met Ser Asn Leu Ser
            1220                1225                1230        
Ala His Gly Val Lys Leu Val Leu Pro Ser Leu Leu Ala Ala Leu Glu
        1235                1240                1245            
Glu Glu Ser Trp Arg Thr Lys Ala Gly Ser Val Glu Leu Leu Gly Ala
    1250                1255                1260                
Met Ala Tyr Cys Ala Pro Lys Gln Leu Ser Ser Cys Leu Pro Asn Ile
1265                1270                1275                1280
Val Pro Lys Leu Thr Glu Val Leu Thr Asp Ser His Val Lys Val Gln
                1285                1290                1295    
Lys Ala Gly Gln Gln Ala Leu Arg Gln Ile Gly Ser Val Ile Arg Asn
            1300                1305                1310        
Pro Glu Ile Leu Ala Ile Ala Pro Val Leu Leu Asp Ala Leu Thr Asp
        1315                1320                1325            
Pro Ser Arg Lys Thr Gln Lys Cys Leu Gln Thr Leu Leu Asp Thr Lys
    1330                1335                1340                
Phe Val His Phe Ile Asp Ala Pro Ser Leu Ala Leu Ile Met Pro Ile
1345                1350                1355                1360
Val Gln Arg Ala Phe Gln Asp Arg Ser Thr Asp Thr Arg Lys Met Ala
                1365                1370                1375    
Ala Gln Ile Ile Gly Asn Met Tyr Ser Leu Thr Asp Gln Lys Asp Leu
            1380                1385                1390        
Ala Pro Tyr Leu Pro Ser Val Thr Pro Gly Leu Lys Ala Ser Leu Leu
        1395                1400                1405            
Asp Pro Val Pro Glu Val Arg Thr Val Ser Ala Lys Ala Leu Gly Ala
    1410                1415                1420                
Met Val Lys Gly Met Gly Glu Ser Cys Phe Glu Asp Leu Leu Pro Trp
1425                1430                1435                1440
Leu Met Glu Thr Leu Thr Tyr Glu Gln Ser Ser Val Asp Arg Ser Gly
                1445                1450                1455    
Ala Ala Gln Gly Leu Ala Glu Val Met Ala Gly Leu Gly Val Glu Lys
            1460                1465                1470        
Leu Glu Lys Leu Met Pro Glu Ile Val Ala Thr Ala Ser Lys Val Asp
        1475                1480                1485            
Ile Ala Pro His Val Arg Asp Gly Tyr Ile Met Met Phe Asn Tyr Leu
    1490                1495                1500                
Pro Ile Thr Phe Gly Asp Lys Phe Thr Pro Tyr Val Gly Pro Ile Ile
1505                1510                1515                1520
Pro Cys Ile Leu Lys Ala Leu Ala Asp Glu Asn Glu Phe Val Arg Asp
                1525                1530                1535    
Thr Ala Leu Arg Ala Gly Gln Arg Val Ile Ser Met Tyr Ala Glu Thr
            1540                1545                1550        
Ala Ile Ala Leu Leu Leu Pro Gln Leu Glu Gln Gly Leu Phe Asp Asp
        1555                1560                1565            
Leu Trp Arg Ile Arg Phe Ser Ser Val Gln Leu Leu Gly Asp Leu Leu
    1570                1575                1580                
Phe His Ile Ser Gly Val Thr Gly Lys Met Thr Thr Glu Thr Ala Ser
1585                1590                1595                1600
Glu Asp Asp Asn Phe Gly Thr Ala Gln Ser Asn Lys Ala Ile Ile Thr
                1605                1610                1615    
Ala Leu Gly Val Glu Arg Arg Asn Arg Val Leu Ala Gly Leu Tyr Met
            1620                1625                1630        
Gly Arg Ser Asp Thr Gln Leu Val Val Arg Gln Ala Ser Leu His Val
        1635                1640                1645            
Trp Lys Ile Val Val Ser Asn Thr Pro Arg Thr Leu Arg Glu Ile Leu
    1650                1655                1660                
Pro Thr Leu Phe Gly Leu Leu Leu Gly Phe Leu Ala Ser Thr Cys Ala
1665                1670                1675                1680
Asp Lys Arg Thr Ile Ala Ala Arg Thr Leu Gly Asp Leu Val Arg Lys
                1685                1690                1695    
Leu Gly Glu Lys Ile Leu Pro Glu Ile Ile Pro Ile Leu Glu Glu Gly
            1700                1705                1710        
Leu Arg Ser Gln Lys Ser Asp Glu Arg Gln Gly Val Cys Ile Gly Leu
        1715                1720                1725            
Ser Glu Ile Met Lys Ser Thr Ser Arg Asp Ala Val Leu Tyr Phe Ser
    1730                1735                1740                
Glu Ser Leu Val Pro Thr Ala Arg Lys Ala Leu Cys Asp Pro Leu Glu
1745                1750                1755                1760
Glu Val Arg Glu Ala Ala Ala Lys Thr Phe Glu Gln Leu His Ser Thr
                1765                1770                1775    
Ile Gly His Gln Ala Leu Glu Asp Ile Leu Pro Phe Leu Leu Lys Gln
            1780                1785                1790        
Leu Asp Asp Glu Glu Val Ser Glu Phe Ala Leu Asp Gly Leu Lys Gln
        1795                1800                1805            
Val Met Ala Ile Lys Ser Arg Val Val Leu Pro Tyr Leu Val Pro Lys
    1810                1815                1820                
Leu Thr Thr Pro Pro Val Asn Thr Arg Val Leu Ala Phe Leu Ser Ser
1825                1830                1835                1840
Val Ala Gly Asp Ala Leu Thr Arg His Leu Gly Val Ile Leu Pro Ala
                1845                1850                1855    
Val Met Leu Ala Leu Lys Glu Lys Leu Gly Thr Pro Asp Glu Gln Leu
            1860                1865                1870        
Glu Met Ala Asn Cys Gln Ala Val Ile Leu Ser Val Glu Asp Asp Thr
        1875                1880                1885            
Gly His Arg Ile Ile Ile Glu Asp Leu Leu Glu Ala Thr Arg Ser Pro
    1890                1895                1900                
Glu Val Gly Met Arg Gln Ala Ala Ala Ile Ile Leu Asn Ile Tyr Cys
1905                1910                1915                1920
Ser Arg Ser Lys Ala Asp Tyr Thr Ser His Leu Arg Ser Leu Val Ser
                1925                1930                1935    
Gly Leu Ile Arg Leu Phe Asn Asp Ser Ser Pro Val Val Leu Glu Glu
            1940                1945                1950        
Ser Trp Asp Ala Leu Asn Ala Ile Thr Lys Lys Leu Asp Ala Gly Asn
        1955                1960                1965            
Gln Leu Ala Leu Ile Glu Glu Leu His Lys Glu Ile Arg Leu Ile Gly
    1970                1975                1980                
Asn Glu Ser Lys Gly Glu His Val Pro Gly Phe Cys Leu Pro Lys Lys
1985                1990                1995                2000
Gly Val Thr Ser Ile Leu Pro Val Leu Arg Glu Gly Val Leu Thr Gly
                2005                2010                2015    
Ser Pro Glu Gln Lys Glu Glu Ala Ala Lys Ala Leu Gly Leu Val Ile
            2020                2025                2030        
Arg Leu Thr Ser Ala Asp Ala Leu Arg Pro Ser Val Val Ser Ile Thr
        2035                2040                2045            
Gly Pro Leu Ile Arg Ile Leu Gly Asp Arg Phe Ser Trp Asn Val Lys
    2050                2055                2060                
Ala Ala Leu Leu Glu Thr Leu Ser Leu Leu Leu Ala Lys Val Gly Ile
2065                2070                2075                2080
Ala Leu Lys Pro Phe Leu Pro Gln Leu Gln Thr Thr Phe Thr Lys Ala
                2085                2090                2095    
Leu Gln Asp Ser Asn Arg Gly Val Arg Leu Lys Ala Ala Asp Ala Leu
            2100                2105                2110        
Gly Lys Leu Ile Ser Ile His Ile Lys Val Asp Pro Leu Phe Thr Glu
        2115                2120                2125            
Leu Leu Asn Gly Ile Arg Ala Met Glu Asp Pro Gly Val Arg Asp Thr
    2130                2135                2140                
Met Leu Gln Ala Leu Arg Phe Val Ile Gln Gly Ala Gly Ala Lys Val
2145                2150                2155                2160
Asp Ala Val Ile Arg Lys Asn Ile Val Ser Leu Leu Leu Ser Met Leu
                2165                2170                2175    
Gly His Asp Glu Asp Asn Thr Arg Ile Ser Ser Ala Gly Cys Leu Gly
            2180                2185                2190        
Glu Leu Cys Ala Phe Leu Thr Glu Glu Glu Leu Ser Ala Val Leu Gln
        2195                2200                2205            
Gln Cys Leu Leu Ala Asp Val Ser Gly Ile Asp Trp Met Val Arg His
    2210                2215                2220                
Gly Arg Ser Leu Ala Leu Ser Val Ala Val Asn Val Ala Pro Gly Arg
2225                2230                2235                2240
Leu Cys Ala Gly Arg Tyr Ser Ser Asp Val Gln Glu Met Ile Leu Ser
                2245                2250                2255    
Ser Ala Thr Ala Asp Arg Ile Pro Ile Ala Val Ser Gly Val Arg Gly
            2260                2265                2270        
Met Gly Phe Leu Met Arg His His Ile Glu Thr Gly Gly Gly Gln Leu
        2275                2280                2285            
Pro Ala Lys Leu Ser Ser Leu Phe Val Lys Cys Leu Gln Asn Pro Ser
    2290                2295                2300                
Ser Asp Ile Arg Leu Val Ala Glu Lys Met Ile Trp Trp Ala Asn Lys
2305                2310                2315                2320
Asp Pro Leu Pro Pro Leu Asp Pro Gln Ala Ile Lys Pro Ile Leu Lys
                2325                2330                2335    
Ala Leu Leu Asp Asn Thr Lys Asp Lys Asn Thr Val Val Arg Ala Tyr
            2340                2345                2350        
Ser Asp Gln Ala Ile Val Asn Leu Leu Lys Met Arg Gln Gly Glu Glu
        2355                2360                2365            
Val Phe Gln Ser Leu Ser Lys Ile Leu Asp Val Ala Ser Leu Glu Val
    2370                2375                2380                
Leu Asn Glu Val Asn Arg Arg Ser Leu Lys Lys Leu Ala Ser Gln Ala
2385                2390                2395                2400
Asp Ser Thr Glu Gln Val Asp Asp Thr Ile Leu Thr
                2405                2410        


<210> 215
<211> 73
<212> PRT
<213> Homo sapiens

<400> 215
Met Glu Leu Pro Lys Leu Lys Leu Ser Gly Val Val Arg Leu Ser Ser
 1               5                  10                  15      
Tyr Ser Ser Pro Thr Leu Gln Ser Val Leu Gly Ser Gly Thr Asn Gly
            20                  25                  30          
Arg Val Pro Val Leu Arg Pro Leu Lys Cys Ile Pro Ala Ser Lys Lys
        35                  40                  45              
Thr Asp Pro Gln Lys Asp Leu Lys Pro Ala Pro Gln Gln Cys Arg Leu
    50                  55                  60                  
Pro Thr Ile Val Arg Lys Gly Gly Arg
65                  70              


<210> 216
<211> 338
<212> PRT
<213> Homo sapiens

<400> 216
Met Asp Gln Asn Asn Ser Leu Pro Pro Tyr Ala Gln Gly Leu Ala Ser
 1               5                  10                  15      
Pro Gln Gly Ala Met Thr Pro Gly Ile Pro Leu Phe Ser Pro Met Met
            20                  25                  30          
Pro Tyr Gly Thr Gly Leu Thr Pro Gln Pro Ile Gln Asn Thr Asn Ser
        35                  40                  45              
Leu Ser Ile Leu Glu Glu Gln Gln Arg Gln Gln Gln Gln Gln Gln Gln
    50                  55                  60                  
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
65                  70                  75                  80  
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Ala Val
                85                  90                  95      
Ala Ala Ala Ala Val Gln Gln Ser Thr Ser Gln Gln Ala Thr Gln Gly
            100                 105                 110         
Thr Ser Gly Gln Ala Pro Gln Leu Phe His Ser Gln Thr Leu Thr Thr
        115                 120                 125             
Ala Pro Leu Pro Gly Thr Thr Pro Leu Tyr Pro Ser Pro Met Thr Pro
    130                 135                 140                 
Met Thr Pro Ile Thr Pro Ala Thr Pro Ala Ser Glu Ser Ser Gly Ile
145                 150                 155                 160 
Val Pro Gln Leu Gln Asn Ile Val Ser Thr Val Asn Leu Gly Cys Lys
                165                 170                 175     
Leu Asp Leu Lys Thr Ile Ala Leu Arg Ala Arg Asn Ala Glu Tyr Asn
            180                 185                 190         
Pro Lys Arg Phe Ala Ala Val Ile Met Arg Ile Arg Glu Pro Arg Thr
        195                 200                 205             
Thr Ala Leu Ile Phe Ser Ser Gly Lys Met Val Cys Thr Gly Ala Lys
    210                 215                 220                 
Ser Glu Glu Gln Ser Arg Leu Ala Ala Arg Lys Tyr Ala Arg Val Val
225                 230                 235                 240 
Gln Lys Leu Gly Phe Pro Ala Lys Phe Leu Asp Phe Lys Ile Gln Asn
                245                 250                 255     
Met Val Gly Ser Cys Asp Val Lys Phe Pro Ile Arg Leu Glu Gly Leu
            260                 265                 270         
Val Leu Thr His Gln Gln Phe Ser Ser Tyr Glu Pro Glu Leu Phe Pro
        275                 280                 285             
Gly Leu Ile Tyr Arg Met Ile Lys Pro Arg Ile Val Leu Leu Ile Phe
    290                 295                 300                 
Val Ser Gly Lys Val Val Leu Thr Gly Ala Lys Val Arg Ala Glu Ile
305                 310                 315                 320 
Tyr Glu Ala Phe Glu Asn Ile Tyr Pro Ile Leu Lys Gly Phe Arg Lys
                325                 330                 335     
Thr Thr
        


<210> 217
<211> 198
<212> PRT
<213> Homo sapiens

<400> 217
Met Ala Tyr Pro Gly His Pro Gly Ala Gly Gly Gly Tyr Tyr Pro Gly
 1               5                  10                  15      
Gly Tyr Gly Gly Ala Pro Gly Gly Pro Ala Phe Pro Gly Gln Thr Gln
            20                  25                  30          
Asp Pro Leu Tyr Gly Tyr Phe Ala Ala Val Ala Gly Gln Asp Gly Gln
        35                  40                  45              
Ile Asp Ala Asp Glu Leu Gln Arg Cys Leu Thr Gln Ser Gly Ile Ala
    50                  55                  60                  
Gly Gly Tyr Lys Pro Phe Asn Leu Glu Thr Cys Arg Leu Met Val Ser
65                  70                  75                  80  
Met Leu Asp Arg Asp Met Ser Gly Thr Met Gly Phe Asn Glu Phe Cys
                85                  90                  95      
Glu Leu Trp Ala Val Leu Asn Gly Trp Arg Gln His Phe Ile Ser Phe
            100                 105                 110         
Asp Thr Asp Arg Ser Gly Thr Val Asp Pro Gln Glu Leu Gln Lys Ala
        115                 120                 125             
Leu Thr Thr Met Gly Phe Arg Leu Ser Pro Gln Ala Val Asn Ser Ile
    130                 135                 140                 
Ala Cys Arg Tyr Ser Thr Asn Gly Lys Ile Thr Phe Asp Asp Tyr Ile
145                 150                 155                 160 
Ala Cys Cys Val Lys Leu Arg Ala Leu Thr Asp Ser Phe Arg Arg Arg
                165                 170                 175     
Asp Thr Ala Gln Gln Gly Val Val Asn Phe Pro Tyr Asp Asp Phe Ile
            180                 185                 190         
Gln Cys Val Met Ser Val
        195             


<210> 218
<211> 1359
<212> PRT
<213> Homo sapiens

<400> 218
Leu Leu Arg Ala Gly Tyr Val Arg Ala Ala Arg Glu Val Lys Glu Gln
 1               5                  10                  15      
Ser Gly Gln Lys Cys Phe Leu Ala Gln Pro Val Thr Leu Leu Asp Ile
            20                  25                  30          
Tyr Thr His Trp Gln Gln Thr Ser Glu Leu Gly Arg Lys Arg Lys Ala
        35                  40                  45              
Glu Glu Asp Ala Ala Leu Gln Ala Lys Lys Thr Arg Val Ser Asp Pro
    50                  55                  60                  
Ile Ser Thr Ser Glu Ser Ser Glu Glu Glu Glu Glu Ala Glu Ala Glu
65                  70                  75                  80  
Thr Ala Lys Ala Thr Pro Arg Leu Ala Ser Thr Asn Ser Ser Val Leu
                85                  90                  95      
Gly Ala Asp Leu Pro Ser Ser Met Lys Glu Lys Ala Lys Ala Glu Thr
            100                 105                 110         
Glu Lys Ala Gly Lys Thr Gly Asn Ser Met Pro His Pro Ala Thr Gly
        115                 120                 125             
Lys Thr Val Ala Asn Leu Leu Ser Gly Lys Ser Pro Arg Lys Ser Ala
    130                 135                 140                 
Glu Pro Ser Ala Asn Thr Thr Leu Val Ser Glu Thr Glu Glu Glu Gly
145                 150                 155                 160 
Ser Val Pro Ala Phe Gly Ala Ala Ala Lys Pro Gly Met Val Ser Ala
                165                 170                 175     
Gly Gln Ala Asp Ser Ser Ser Glu Asp Thr Ser Ser Ser Ser Asp Glu
            180                 185                 190         
Thr Asp Val Glu Val Lys Ala Ser Glu Lys Ile Leu Gln Val Arg Ala
        195                 200                 205             
Ala Ser Ala Pro Ala Lys Gly Thr Pro Gly Lys Gly Ala Thr Pro Ala
    210                 215                 220                 
Pro Pro Gly Lys Ala Gly Ala Val Ala Ser Gln Thr Lys Ala Gly Lys
225                 230                 235                 240 
Pro Glu Glu Asp Ser Glu Ser Ser Ser Glu Glu Ser Ser Asp Ser Glu
                245                 250                 255     
Glu Glu Thr Pro Ala Ala Lys Ala Leu Leu Gln Ala Lys Ala Ser Gly
            260                 265                 270         
Lys Thr Ser Gln Val Gly Ala Ala Ser Ala Pro Ala Lys Glu Ser Pro
        275                 280                 285             
Arg Lys Gly Ala Ala Pro Ala Pro Pro Gly Lys Thr Gly Pro Ala Val
    290                 295                 300                 
Ala Lys Ala Gln Ala Gly Lys Arg Glu Glu Asp Ser Gln Ser Ser Ser
305                 310                 315                 320 
Glu Glu Ser Asp Ser Glu Glu Glu Ala Pro Ala Gln Ala Lys Pro Ser
                325                 330                 335     
Gly Lys Ala Pro Gln Val Arg Ala Ala Ser Ala Pro Ala Lys Glu Ser
            340                 345                 350         
Pro Arg Lys Gly Ala Ala Pro Ala Pro Pro Arg Lys Thr Gly Pro Ala
        355                 360                 365             
Ala Ala Gln Val Gln Val Gly Lys Gln Glu Glu Asp Ser Arg Ser Ser
    370                 375                 380                 
Ser Glu Glu Ser Asp Ser Asp Arg Glu Ala Leu Ala Ala Met Asn Ala
385                 390                 395                 400 
Ala Gln Val Lys Pro Leu Gly Lys Ser Pro Gln Val Lys Pro Ala Ser
                405                 410                 415     
Thr Met Gly Met Gly Pro Leu Gly Lys Gly Ala Gly Pro Val Pro Pro
            420                 425                 430         
Gly Lys Val Gly Pro Ala Thr Pro Ser Ala Gln Val Gly Lys Trp Glu
        435                 440                 445             
Glu Asp Ser Glu Ser Ser Ser Glu Glu Ser Ser Asp Ser Ser Asp Gly
    450                 455                 460                 
Glu Val Pro Thr Ala Val Ala Pro Ala Gln Glu Lys Ser Leu Gly Asn
465                 470                 475                 480 
Ile Leu Gln Ala Lys Pro Thr Ser Ser Pro Ala Lys Gly Pro Pro Gln
                485                 490                 495     
Lys Ala Gly Pro Val Ala Val Gln Val Lys Ala Glu Lys Pro Met Asp
            500                 505                 510         
Asn Ser Glu Ser Ser Glu Glu Ser Ser Asp Ser Ala Asp Ser Glu Glu
        515                 520                 525             
Ala Pro Ala Ala Met Thr Ala Ala Gln Ala Lys Pro Ala Leu Lys Ile
    530                 535                 540                 
Pro Gln Thr Lys Ala Cys Pro Lys Lys Thr Asn Thr Thr Ala Ser Ala
545                 550                 555                 560 
Lys Val Ala Pro Val Arg Val Gly Thr Gln Pro Pro Arg Lys Ala Gly
                565                 570                 575     
Thr Ala Thr Ser Pro Ala Gly Ser Ser Pro Ala Val Ala Gly Gly Thr
            580                 585                 590         
Gln Arg Pro Ala Glu Asp Ser Ser Ser Ser Glu Glu Ser Asp Ser Glu
        595                 600                 605             
Glu Glu Lys Thr Gly Leu Ala Val Thr Val Gly Gln Ala Lys Ser Val
    610                 615                 620                 
Gly Lys Gly Leu Gln Val Lys Ala Ala Ser Val Pro Val Lys Gly Ser
625                 630                 635                 640 
Leu Gly Gln Gly Thr Ala Pro Val Leu Pro Gly Lys Thr Gly Pro Thr
                645                 650                 655     
Val Thr Gln Val Lys Ala Glu Lys Gln Glu Asp Ser Glu Ser Ser Glu
            660                 665                 670         
Glu Glu Ser Asp Ser Glu Glu Ala Ala Ala Ser Pro Ala Gln Val Lys
        675                 680                 685             
Thr Ser Val Lys Lys Thr Gln Ala Lys Ala Asn Pro Ala Ala Ala Arg
    690                 695                 700                 
Ala Pro Ser Ala Lys Gly Thr Ile Ser Ala Pro Gly Lys Val Val Thr
705                 710                 715                 720 
Ala Ala Ala Gln Ala Lys Gln Arg Ser Pro Ser Lys Val Lys Pro Pro
                725                 730                 735     
Val Arg Asn Pro Gln Asn Ser Thr Val Leu Ala Arg Gly Pro Ala Ser
            740                 745                 750         
Val Pro Ser Val Gly Lys Ala Val Ala Thr Ala Ala Gln Ala Gln Thr
        755                 760                 765             
Gly Pro Glu Glu Asp Ser Gly Ser Ser Glu Glu Glu Ser Asp Ser Glu
    770                 775                 780                 
Glu Glu Ala Glu Thr Leu Ala Gln Ala Lys Pro Ser Gly Lys Thr His
785                 790                 795                 800 
Gln Ile Arg Ala Ala Leu Ala Pro Ala Lys Glu Ser Pro Arg Lys Gly
                805                 810                 815     
Ala Ala Pro Thr Pro Pro Gly Lys Thr Gly Pro Ser Ala Ala Gln Ala
            820                 825                 830         
Gly Lys Gln Asp Asp Ser Gly Ser Ser Ser Glu Glu Ser Asp Ser Asp
        835                 840                 845             
Gly Glu Ala Pro Ala Ala Val Thr Ser Ala Gln Val Ile Lys Pro Pro
    850                 855                 860                 
Leu Ile Phe Val Asp Pro Asn Arg Ser Pro Ala Gly Pro Ala Ala Thr
865                 870                 875                 880 
Pro Ala Gln Ala Gln Ala Ala Ser Thr Pro Arg Lys Ala Arg Ala Ser
                885                 890                 895     
Glu Ser Thr Ala Arg Ser Ser Ser Ser Glu Ser Glu Asp Glu Asp Val
            900                 905                 910         
Ile Pro Ala Thr Gln Cys Leu Thr Pro Gly Ile Arg Thr Asn Val Val
        915                 920                 925             
Thr Met Pro Thr Ala His Pro Arg Ile Ala Pro Lys Ala Ser Met Ala
    930                 935                 940                 
Gly Ala Ser Ser Ser Lys Glu Ser Ser Arg Ile Ser Asp Gly Lys Lys
945                 950                 955                 960 
Gln Glu Gly Pro Ala Thr Gln Val Ser Lys Lys Asn Pro Ala Ser Leu
                965                 970                 975     
Pro Leu Thr Gln Ala Ala Leu Lys Val Leu Ala Gln Lys Ala Ser Glu
            980                 985                 990         
Ala Gln Pro Pro Val Ala Arg Thr Gln Pro Ser Ser Gly Val Asp Ser
        995                 1000                1005            
Ala Val Gly Thr Leu Pro Ala Thr Ser Pro Gln Ser Thr Ser Val Gln
    1010                1015                1020                
Ala Lys Gly Thr Asn Lys Leu Arg Lys Pro Lys Leu Pro Glu Val Gln
1025                1030                1035                1040
Gln Ala Thr Lys Ala Pro Glu Ser Ser Asp Asp Ser Glu Asp Ser Ser
                1045                1050                1055    
Asp Ser Ser Ser Gly Ser Glu Glu Asp Gly Glu Gly Pro Gln Gly Ala
            1060                1065                1070        
Lys Ser Ala His Thr Leu Gly Pro Thr Pro Ser Arg Thr Glu Thr Leu
        1075                1080                1085            
Val Glu Glu Thr Ala Ala Glu Ser Ser Glu Asp Asp Val Val Ala Pro
    1090                1095                1100                
Ser Gln Ser Leu Leu Ser Gly Tyr Met Thr Pro Gly Leu Thr Pro Ala
1105                1110                1115                1120
Asn Ser Gln Ala Ser Lys Ala Thr Pro Lys Leu Asp Ser Ser Pro Ser
                1125                1130                1135    
Val Ser Ser Thr Leu Ala Ala Lys Asp Asp Pro Asp Gly Lys Gln Glu
            1140                1145                1150        
Ala Lys Pro Gln Gln Ala Ala Gly Met Leu Ser Pro Lys Thr Gly Gly
        1155                1160                1165            
Lys Glu Ala Ala Ser Gly Thr Thr Pro Gln Lys Ser Arg Lys Pro Lys
    1170                1175                1180                
Lys Gly Ala Gly Asn Pro Gln Ala Ser Thr Leu Ala Leu Gln Ser Asn
1185                1190                1195                1200
Ile Thr Gln Cys Leu Leu Gly Gln Pro Trp Pro Leu Asn Glu Ala Gln
                1205                1210                1215    
Val Gln Ala Ser Val Val Lys Val Leu Thr Glu Leu Leu Glu Gln Glu
            1220                1225                1230        
Arg Lys Lys Val Val Asp Thr Thr Lys Glu Ser Ser Arg Lys Gly Trp
        1235                1240                1245            
Glu Ser Arg Lys Arg Lys Leu Ser Gly Asp Gln Pro Ala Ala Arg Thr
    1250                1255                1260                
Pro Arg Ser Lys Lys Lys Lys Lys Leu Gly Ala Gly Glu Gly Gly Glu
1265                1270                1275                1280
Ala Ser Val Ser Pro Glu Lys Thr Ser Thr Thr Ser Lys Gly Gln Ala
                1285                1290                1295    
Lys Arg Asp Lys Ala Ser Gly Asp Val Lys Glu Lys Lys Gly Lys Gly
            1300                1305                1310        
Ser Leu Gly Ser Gln Gly Ala Lys Asp Glu Pro Glu Glu Glu Leu Gln
        1315                1320                1325            
Lys Gly Met Gly Thr Val Glu Gly Gly Asp Gln Ser Asn Pro Lys Ser
    1330                1335                1340                
Lys Lys Glu Lys Lys Lys Ser Asp Lys Arg Lys Lys Asp Lys Lys
1345                1350                1355                


<210> 219
<211> 1862
<212> PRT
<213> Homo sapiens

<400> 219
Met Glu Pro Ser Ser Pro Gln Asp Glu Gly Leu Arg Lys Lys Gln Pro
 1               5                  10                  15      
Lys Lys Pro Val Pro Glu Ile Leu Pro Ser Pro Pro Arg Ala Leu Phe
            20                  25                  30          
Cys Leu Thr Leu Glu Asn Pro Leu Arg Lys Ala Cys Ile Ser Ile Val
        35                  40                  45              
Glu Trp Lys Pro Phe Glu Thr Ile Ile Leu Leu Thr Ile Phe Ala Asn
    50                  55                  60                  
Cys Val Ala Leu Ala Val Tyr Leu Pro Met Pro Glu Asp Asp Asn Asn
65                  70                  75                  80  
Ser Leu Asn Leu Gly Leu Glu Lys Leu Glu Tyr Phe Phe Leu Ile Val
                85                  90                  95      
Phe Ser Ile Glu Ala Ala Met Lys Ile Ile Ala Tyr Gly Phe Leu Phe
            100                 105                 110         
His Gln Asp Ala Tyr Leu Arg Ser Gly Trp Asn Val Leu Asp Phe Thr
        115                 120                 125             
Ile Val Phe Leu Gly Val Phe Thr Val Ile Leu Glu Gln Val Asn Val
    130                 135                 140                 
Ile Gln Ser His Thr Ala Pro Met Ser Ser Lys Gly Ala Gly Leu Asp
145                 150                 155                 160 
Val Lys Ala Leu Arg Ala Phe Arg Val Leu Arg Pro Leu Arg Leu Val
                165                 170                 175     
Ser Gly Val Pro Ser Leu Gln Val Val Leu Asn Ser Ile Phe Lys Ala
            180                 185                 190         
Met Leu Pro Leu Phe His Ile Ala Leu Leu Val Leu Phe Met Val Ile
        195                 200                 205             
Ile Tyr Ala Ile Ile Gly Leu Glu Leu Phe Lys Gly Lys Met His Lys
    210                 215                 220                 
Thr Cys Tyr Phe Ile Gly Thr Asp Ile Val Ala Thr Val Glu Asn Glu
225                 230                 235                 240 
Glu Pro Ser Pro Cys Ala Arg Thr Gly Ser Gly Arg Arg Cys Thr Ile
                245                 250                 255     
Asn Gly Ser Glu Cys Arg Gly Gly Cys Pro Gly Pro Asn His Gly Ile
            260                 265                 270         
Thr His Phe Asp Asn Phe Gly Phe Ser Met Leu Thr Val Tyr Gln Cys
        275                 280                 285             
Ile Thr Met Glu Gly Trp Thr Asp Val Leu Tyr Trp Val Asn Asp Ala
    290                 295                 300                 
Ile Gly Asn Glu Trp Pro Trp Ile Tyr Phe Val Thr Leu Ile Leu Leu
305                 310                 315                 320 
Gly Ser Phe Phe Ile Leu Asn Leu Val Leu Gly Val Leu Ser Gly Glu
                325                 330                 335     
Phe Thr Lys Glu Arg Glu Lys Ala Lys Ser Arg Gly Thr Phe Gln Lys
            340                 345                 350         
Leu Arg Glu Lys Gln Gln Leu Asp Glu Asp Leu Arg Gly Tyr Met Ser
        355                 360                 365             
Trp Ile Thr Gln Gly Glu Val Met Asp Val Glu Asp Phe Arg Glu Gly
    370                 375                 380                 
Lys Leu Ser Leu Asp Glu Gly Gly Ser Asp Thr Glu Ser Leu Tyr Glu
385                 390                 395                 400 
Ile Ala Gly Leu Asn Lys Ile Ile Gln Phe Ile Arg His Trp Arg Gln
                405                 410                 415     
Trp Asn Arg Ile Phe Arg Trp Lys Cys His Asp Ile Val Lys Ser Lys
            420                 425                 430         
Val Phe Tyr Trp Leu Val Ile Leu Ile Val Ala Leu Asn Thr Leu Ser
        435                 440                 445             
Ile Ala Ser Glu His His Asn Gln Pro Leu Trp Leu Thr Arg Leu Gln
    450                 455                 460                 
Asp Ile Ala Asn Arg Val Leu Leu Ser Leu Phe Thr Thr Glu Met Leu
465                 470                 475                 480 
Met Lys Met Tyr Gly Leu Gly Leu Arg Gln Tyr Phe Met Ser Ile Phe
                485                 490                 495     
Asn Arg Phe Asp Cys Phe Val Val Cys Ser Gly Ile Leu Glu Ile Leu
            500                 505                 510         
Leu Val Glu Ser Gly Ala Met Thr Pro Leu Gly Ile Ser Val Leu Arg
        515                 520                 525             
Cys Ile Arg Leu Leu Arg Ile Phe Lys Ile Thr Lys Tyr Trp Thr Ser
    530                 535                 540                 
Leu Ser Asn Leu Val Ala Ser Leu Leu Asn Ser Ile Arg Ser Ile Ala
545                 550                 555                 560 
Ser Leu Leu Leu Leu Leu Phe Leu Phe Ile Val Ile Phe Arg Leu Leu
                565                 570                 575     
Gly Met Gln Leu Phe Gly Gly Arg Tyr Asp Phe Glu Asp Thr Glu Val
            580                 585                 590         
Arg Arg Ser Asn Phe Asp Asn Phe Pro Gln Ala Leu Ile Ser Val Phe
        595                 600                 605             
Gln Val Leu Thr Gly Glu Asp Trp Thr Ser Met Met Tyr Asn Gly Ile
    610                 615                 620                 
Met Ala Tyr Arg Gly Pro Ser Tyr Pro Gly Met Leu Val Cys Ile Tyr
625                 630                 635                 640 
Phe Ile Ile Leu Phe Val Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe
                645                 650                 655     
Leu Ala Ile Ala Val Asp Asn Leu Ala Glu Ala Glu Ser Leu Thr Ser
            660                 665                 670         
Ala Gln Lys Ala Lys Ala Glu Glu Lys Lys Arg Arg Lys Met Ser Lys
        675                 680                 685             
Gly Leu Pro Asp Lys Ser Glu Glu Glu Lys Ser Thr Met Ala Lys Lys
    690                 695                 700                 
Leu Glu Gln Lys Pro Lys Gly Glu Gly Ile Pro Thr Thr Ala Lys Leu
705                 710                 715                 720 
Lys Ile Asp Glu Phe Glu Ser Asn Val Asn Glu Val Lys Asp Pro Tyr
                725                 730                 735     
Pro Ser Ala Asp Phe Pro Gly Asp Asp Glu Glu Asp Glu Pro Glu Ile
            740                 745                 750         
Pro Leu Ser Pro Arg Pro Arg Pro Leu Ala Glu Leu Gln Leu Lys Glu
        755                 760                 765             
Lys Ala Val Pro Ile Pro Glu Ala Ser Ser Phe Phe Ile Phe Ser Pro
    770                 775                 780                 
Thr Asn Lys Ile Arg Val Leu Cys His Arg Ile Val Asn Ala Thr Trp
785                 790                 795                 800 
Phe Thr Asn Phe Ile Leu Leu Phe Ile Leu Leu Ser Ser Ala Ala Leu
                805                 810                 815     
Ala Ala Glu Asp Pro Ile Arg Ala Asp Ser Met Arg Asn Gln Ile Leu
            820                 825                 830         
Lys His Phe Asp Ile Gly Phe Thr Ser Val Phe Thr Val Glu Ile Val
        835                 840                 845             
Leu Lys Met Thr Thr Tyr Gly Ala Phe Leu His Lys Gly Ser Phe Cys
    850                 855                 860                 
Arg Asn Tyr Phe Asn Met Leu Asp Leu Leu Val Val Ala Val Ser Leu
865                 870                 875                 880 
Ile Ser Met Gly Leu Glu Ser Ser Ala Ile Ser Val Val Lys Ile Leu
                885                 890                 895     
Arg Val Leu Arg Val Leu Arg Pro Leu Arg Ala Ile Asn Arg Ala Lys
            900                 905                 910         
Gly Leu Lys Cys Met Phe Val Ala Ile Ser Thr Ile Gly Asn Ile Val
        915                 920                 925             
Leu Val Thr Thr Leu Leu Gln Phe Met Phe Ala Cys Ile Gly Val Gln
    930                 935                 940                 
Leu Phe Lys Gly Lys Phe Phe Arg Cys Thr Asp Leu Ser Lys Met Thr
945                 950                 955                 960 
Glu Glu Glu Cys Arg Gly Tyr Tyr Tyr Val Tyr Lys Asp Gly Asp Pro
                965                 970                 975     
Met Gln Ile Glu Leu Arg His Arg Glu Trp Val His Ser Asp Phe His
            980                 985                 990         
Phe Asp Asn Val Leu Ser Ala Met Met Ser Leu Phe Thr Val Ser Thr
        995                 1000                1005            
Phe Glu Gly Trp Pro Gln Leu Leu Tyr Lys Ala Ile Asp Ser Asn Ala
    1010                1015                1020                
Glu Asp Val Gly Pro Ile Tyr Asn Asn Arg Val Glu Met Ala Ile Phe
1025                1030                1035                1040
Phe Ile Ile Tyr Ile Ile Leu Ile Ala Phe Phe Met Met Asn Ile Phe
                1045                1050                1055    
Val Gly Phe Val Ile Val Thr Phe Gln Glu Gln Gly Glu Thr Glu Tyr
            1060                1065                1070        
Lys Asn Cys Glu Leu Asp Lys Asn Gln Arg Gln Cys Val Gln Tyr Ala
        1075                1080                1085            
Leu Lys Ala Arg Pro Leu Arg Cys Tyr Ile Pro Lys Asn Pro Tyr Gln
    1090                1095                1100                
Tyr Gln Val Trp Tyr Ile Val Thr Ser Ser Tyr Phe Glu Tyr Leu Met
1105                1110                1115                1120
Phe Ala Leu Ile Met Leu Asn Thr Ile Cys Leu Gly Met Gln His Tyr
                1125                1130                1135    
Asn Gln Ser Glu Gln Met Asn His Ile Ser Asp Ile Leu Asn Val Ala
            1140                1145                1150        
Phe Thr Ile Ile Phe Thr Leu Glu Met Ile Leu Lys Leu Met Ala Phe
        1155                1160                1165            
Lys Ala Arg Gly Tyr Phe Gly Asn Pro Trp Asn Val Phe Asp Phe Leu
    1170                1175                1180                
Ile Val Ile Gly Ser Ile Ile Asp Val Ile Leu Ser Glu Ile Asp Thr
1185                1190                1195                1200
Phe Leu Ala Ser Ser Gly Gly Leu Tyr Cys Leu Gly Gly Gly Cys Gly
                1205                1210                1215    
Asn Val Asp Pro Asp Glu Ser Ala Arg Ile Ser Ser Ala Phe Phe Arg
            1220                1225                1230        
Leu Phe Arg Val Met Arg Leu Ile Lys Leu Leu Ser Arg Ala Glu Gly
        1235                1240                1245            
Val Arg Thr Leu Leu Trp Thr Phe Ile Lys Ser Phe Gln Ala Leu Pro
    1250                1255                1260                
Tyr Val Ala Leu Leu Ile Val Met Leu Phe Phe Ile Tyr Ala Val Ile
1265                1270                1275                1280
Gly Met Gln Met Phe Gly Lys Ile Ala Leu Val Asp Gly Thr Gln Ile
                1285                1290                1295    
Asn Arg Asn Asn Asn Phe Gln Thr Phe Pro Gln Ala Val Leu Leu Leu
            1300                1305                1310        
Phe Arg Cys Ala Thr Gly Glu Ala Trp Gln Glu Ile Leu Leu Ala Cys
        1315                1320                1325            
Ser Tyr Gly Lys Leu Cys Asp Pro Glu Ser Asp Tyr Ala Pro Gly Glu
    1330                1335                1340                
Glu Tyr Thr Cys Gly Thr Asn Phe Ala Tyr Tyr Tyr Phe Ile Ser Phe
1345                1350                1355                1360
Tyr Met Leu Cys Ala Phe Leu Val Ile Asn Leu Phe Val Ala Val Ile
                1365                1370                1375    
Met Asp Asn Phe Asp Tyr Leu Thr Arg Asp Trp Ser Ile Leu Gly Pro
            1380                1385                1390        
His His Leu Asp Glu Phe Lys Ala Ile Trp Ala Glu Tyr Asp Pro Glu
        1395                1400                1405            
Ala Lys Gly Arg Ile Lys His Leu Asp Val Val Thr Leu Leu Arg Arg
    1410                1415                1420                
Ile Gln Pro Pro Leu Gly Phe Gly Lys Phe Cys Pro His Arg Val Ala
1425                1430                1435                1440
Cys Lys Arg Leu Val Gly Met Asn Met Pro Leu Asn Ser Asp Gly Thr
                1445                1450                1455    
Val Thr Phe Asn Ala Thr Leu Phe Ala Leu Val Gly Thr Ala Leu Lys
            1460                1465                1470        
Ile Lys Thr Glu Gly Asn Phe Glu Gln Ala Asn Glu Glu Leu Arg Ala
        1475                1480                1485            
Ile Ile Lys Lys Ile Trp Lys Arg Thr Ser Met Lys Leu Leu Asp Gln
    1490                1495                1500                
Val Asp Asp Glu Val Thr Val Gly Lys Phe Tyr Ala Thr Phe Leu Ile
1505                1510                1515                1520
Gln Glu Asp Phe Arg Lys Phe Met Lys Arg Gln Glu Glu Tyr Tyr Gly
                1525                1530                1535    
Tyr Arg Pro Lys Lys Asp Ile Val Gln Ile Gln Ala Gly Leu Arg Thr
            1540                1545                1550        
Ile Glu Glu Glu Ala Ala Pro Glu Ile Cys Arg Thr Val Ser Gly Asp
        1555                1560                1565            
Leu Ala Ala Glu Glu Glu Leu Glu Arg Ala Met Val Glu Ala Ala Met
    1570                1575                1580                
Glu Glu Gly Ile Phe Arg Arg Thr Gly Gly Leu Phe Gly Gln Val Asp
1585                1590                1595                1600
Asn Phe Leu Glu Arg Thr Asn Ser Leu Pro Pro Val Met Ala Asn Gln
                1605                1610                1615    
Arg Pro Leu Gln Phe Ala Glu Ile Glu Met Glu Glu Met Glu Ser Pro
            1620                1625                1630        
Val Phe Leu Glu Asp Phe Pro Gln Asp Pro Arg Thr Asn Pro Leu Ala
        1635                1640                1645            
Arg Ala Asn Thr Asn Asn Ala Asn Ala Asn Val Ala Tyr Ala Asn Ser
    1650                1655                1660                
Asn His Ser Asn Ser His Val Phe Ser Ser Val His Tyr Glu Arg Glu
1665                1670                1675                1680
Phe Pro Glu Glu Thr Glu Thr Pro Ala Thr Arg Gly Arg Ala Leu Gly
                1685                1690                1695    
Gln Pro Cys Arg Gly Pro His Ser Lys Pro Cys Val Glu Met Leu Lys
            1700                1705                1710        
Gly Leu Leu Thr Gln Arg Ala Met Pro Arg Gly Gln Ala Pro Pro Ala
        1715                1720                1725            
Pro Cys Gln Cys Pro Arg Val Glu Ser Ser Met Pro Glu Asp Arg Lys
    1730                1735                1740                
Ser Ser Thr Pro Gly Ser Leu His Glu Glu Thr Pro His Ser Arg Ser
1745                1750                1755                1760
Thr Arg Glu Asn Thr Ser Arg Cys Ser Ala Pro Ala Thr Ala Leu Leu
                1765                1770                1775    
Ile Gln Lys Ala Leu Val Arg Gly Gly Leu Gly Thr Leu Ala Ala Asp
            1780                1785                1790        
Ala Asn Phe Ile Met Ala Thr Gly Gln Ala Leu Gly Asp Ala Cys Gln
        1795                1800                1805            
Met Glu Pro Glu Glu Val Glu Ile Met Ala Thr Glu Leu Leu Lys Gly
    1810                1815                1820                
Arg Glu Ala Pro Asp Gly Met Ala Ser Ser Leu Gly Cys Leu Asn Leu
1825                1830                1835                1840
Gly Ser Ser Leu Gly Ser Leu Asp Gln His Gln Gly Ser Gln Glu Thr
                1845                1850                1855    
Leu Ile Pro Pro Arg Leu
            1860        


<210> 220
<211> 268
<212> PRT
<213> Homo sapiens

<400> 220
Met Ala Ala Val Arg Ala Leu Val Ala Ser Arg Leu Ala Ala Ala Ser
 1               5                  10                  15      
Ala Phe Thr Ser Leu Ser Pro Gly Gly Arg Thr Pro Ser Gln Arg Ala
            20                  25                  30          
Ala Leu His Leu Ser Val Pro Arg Pro Ala Ala Arg Val Ala Leu Val
        35                  40                  45              
Leu Ser Gly Cys Gly Val Tyr Asp Gly Thr Glu Ile His Glu Ala Ser
    50                  55                  60                  
Ala Ile Leu Val His Leu Ser Arg Gly Gly Ala Glu Val Gln Ile Phe
65                  70                  75                  80  
Ala Pro Asp Val Pro Gln Met His Val Ile Asp His Thr Lys Gly Gln
                85                  90                  95      
Pro Ser Glu Gly Glu Ser Arg Asn Val Leu Thr Glu Ser Ala Arg Ile
            100                 105                 110         
Ala Arg Gly Lys Ile Thr Asp Leu Ala Asn Leu Ser Ala Ala Asn His
        115                 120                 125             
Asp Ala Ala Ile Phe Pro Gly Gly Phe Gly Ala Ala Lys Asn Leu Ser
    130                 135                 140                 
Thr Phe Ala Val Asp Gly Lys Asp Cys Lys Val Asn Lys Glu Val Glu
145                 150                 155                 160 
Arg Val Leu Lys Glu Phe His Gln Ala Gly Lys Pro Ile Gly Leu Cys
                165                 170                 175     
Cys Ile Ala Pro Val Leu Ala Ala Lys Val Leu Arg Gly Val Glu Val
            180                 185                 190         
Thr Val Gly His Glu Gln Glu Glu Gly Gly Lys Trp Pro Tyr Ala Gly
        195                 200                 205             
Thr Ala Glu Ala Met Lys Ala Leu Gly Ala Lys His Cys Val Lys Glu
    210                 215                 220                 
Val Val Glu Ala His Val Asp Gln Lys Asn Lys Val Val Thr Thr Pro
225                 230                 235                 240 
Ala Phe Met Cys Glu Thr Ala Leu His Tyr Ile His Asp Gly Ile Gly
                245                 250                 255     
Ala Met Val Arg Lys Val Leu Glu Leu Thr Gly Lys
            260                 265             


<210> 221
<211> 86
<212> PRT
<213> Homo sapiens

<400> 221
Met Ala Gln Pro Ile Leu Gly His Gly Ser Leu Gln Pro Ala Ser Ala
 1               5                  10                  15      
Ala Gly Leu Ala Ser Leu Glu Leu Asp Ser Ser Leu Asp Gln Tyr Val
            20                  25                  30          
Gln Ile Arg Ile Phe Lys Ile Ile Val Ile Gly Asp Ser Asn Val Gly
        35                  40                  45              
Lys Thr Cys Leu Thr Phe Arg Phe Cys Gly Gly Thr Phe Pro Asp Lys
    50                  55                  60                  
Thr Glu Ala Thr Ile Gly Val Asp Phe Arg Glu Lys Thr Val Glu Ile
65                  70                  75                  80  
Glu Gly Glu Lys Ile Lys
                85      


<210> 222
<211> 482
<212> PRT
<213> Homo sapiens

<400> 222
Met Ala Gln Thr Gln Gly Thr Arg Arg Lys Val Cys Tyr Tyr Tyr Asp
 1               5                  10                  15      
Gly Asp Val Gly Asn Tyr Tyr Tyr Gly Gln Gly His Pro Met Lys Pro
            20                  25                  30          
His Arg Ile Arg Met Thr His Asn Leu Leu Leu Asn Tyr Gly Leu Tyr
        35                  40                  45              
Arg Lys Met Glu Ile Tyr Arg Pro His Lys Ala Asn Ala Glu Glu Met
    50                  55                  60                  
Thr Lys Tyr His Ser Asp Asp Tyr Ile Lys Phe Leu Arg Ser Ile Arg
65                  70                  75                  80  
Pro Asp Asn Met Ser Glu Tyr Ser Lys Gln Met Gln Arg Phe Asn Val
                85                  90                  95      
Gly Glu Asp Cys Pro Val Phe Asp Gly Leu Phe Glu Phe Cys Gln Leu
            100                 105                 110         
Ser Thr Gly Gly Ser Val Ala Ser Ala Val Lys Leu Asn Lys Gln Gln
        115                 120                 125             
Thr Asp Ile Ala Val Asn Trp Ala Gly Gly Leu His His Ala Lys Lys
    130                 135                 140                 
Ser Glu Ala Ser Gly Phe Cys Tyr Val Asn Asp Ile Val Leu Ala Ile
145                 150                 155                 160 
Leu Glu Leu Leu Lys Tyr His Gln Arg Val Leu Tyr Ile Asp Ile Asp
                165                 170                 175     
Ile His His Gly Asp Gly Val Glu Glu Ala Phe Tyr Thr Thr Asp Arg
            180                 185                 190         
Val Met Thr Val Ser Phe His Lys Tyr Gly Glu Tyr Phe Pro Gly Thr
        195                 200                 205             
Gly Asp Leu Arg Asp Ile Gly Ala Gly Lys Gly Lys Tyr Tyr Ala Val
    210                 215                 220                 
Asn Tyr Pro Leu Arg Asp Gly Ile Asp Asp Glu Ser Tyr Glu Ala Ile
225                 230                 235                 240 
Phe Lys Pro Val Met Ser Lys Val Met Glu Met Phe Gln Pro Ser Ala
                245                 250                 255     
Val Val Leu Gln Cys Gly Ser Asp Ser Leu Ser Gly Asp Arg Leu Gly
            260                 265                 270         
Cys Phe Asn Leu Thr Ile Lys Gly His Ala Lys Cys Val Glu Phe Val
        275                 280                 285             
Lys Ser Phe Asn Leu Pro Met Leu Met Leu Gly Gly Gly Gly Tyr Thr
    290                 295                 300                 
Ile Arg Asn Val Ala Arg Cys Arg Thr Tyr Glu Thr Ala Val Ala Leu
305                 310                 315                 320 
Asp Thr Glu Ile Pro Asn Glu Leu Pro Tyr Asn Asp Tyr Phe Glu Tyr
                325                 330                 335     
Phe Gly Pro Asp Phe Lys Leu His Ile Ser Pro Ser Asn Met Thr Asn
            340                 345                 350         
Gln Asn Thr Asn Glu Tyr Leu Glu Lys Ile Lys Gln Arg Leu Phe Glu
        355                 360                 365             
Asn Leu Arg Met Leu Pro His Ala Pro Gly Val Gln Met Gln Ala Ile
    370                 375                 380                 
Pro Glu Asp Ala Ile Pro Glu Glu Ser Gly Asp Glu Asp Glu Asp Asp
385                 390                 395                 400 
Pro Asp Lys Arg Ile Ser Ile Cys Ser Ser Asp Lys Arg Ile Ala Cys
                405                 410                 415     
Glu Glu Glu Phe Ser Asp Ser Glu Glu Glu Gly Glu Gly Gly Arg Lys
            420                 425                 430         
Asn Ser Ser Asn Phe Lys Lys Ala Lys Arg Val Lys Thr Glu Asp Glu
        435                 440                 445             
Lys Glu Lys Asp Pro Glu Glu Lys Lys Glu Val Thr Glu Glu Glu Lys
    450                 455                 460                 
Thr Lys Glu Glu Lys Pro Glu Ala Lys Gly Val Lys Glu Glu Val Lys
465                 470                 475                 480 
Leu Ala
        


<210> 223
<211> 136
<212> PRT
<213> Homo sapiens

<400> 223
Met Ser Ala Ala Val Thr Ala Gly Lys Leu Ala Arg Ala Pro Ala Asp
 1               5                  10                  15      
Pro Gly Lys Ala Gly Val Pro Gly Val Ala Ala Pro Gly Ala Pro Ala
            20                  25                  30          
Ala Ala Pro Pro Ala Lys Glu Ile Pro Glu Val Leu Val Asp Pro Arg
        35                  40                  45              
Ser Arg Arg Arg Tyr Val Arg Gly Arg Phe Leu Gly Lys Gly Gly Phe
    50                  55                  60                  
Ala Lys Cys Phe Glu Ile Ser Asp Val Asp Thr Lys Glu Val Phe Ala
65                  70                  75                  80  
Gly Lys Ile Val Pro Lys Ser Leu Leu Leu Lys Pro His Gln Arg Glu
                85                  90                  95      
Lys Met Ser Met Glu Ile Ser Ile His Arg Ser Leu Ala His Gln His
            100                 105                 110         
Val Val Gly Phe His Gly Phe Phe Glu Asp Asn Asp Phe Val Phe Val
        115                 120                 125             
Val Leu Glu Leu Cys Arg Arg Arg
    130                 135     


<210> 224
<211> 452
<212> PRT
<213> Homo sapiens

<400> 224
Met Ala Ala Ala Thr Leu Leu Arg Ala Thr Pro His Phe Ser Gly Leu
 1               5                  10                  15      
Ala Ala Gly Arg Thr Phe Leu Leu Gln Gly Leu Leu Arg Leu Leu Lys
            20                  25                  30          
Ala Pro Ala Leu Pro Leu Leu Cys Arg Gly Leu Ala Val Glu Ala Lys
        35                  40                  45              
Lys Thr Tyr Val Arg Asp Lys Pro His Val Asn Val Gly Thr Ile Gly
    50                  55                  60                  
His Val Asp His Gly Lys Thr Thr Leu Thr Ala Ala Ile Thr Lys Ile
65                  70                  75                  80  
Leu Ala Glu Gly Gly Gly Ala Lys Phe Lys Lys Tyr Glu Glu Ile Asp
                85                  90                  95      
Asn Ala Pro Glu Glu Arg Ala Arg Gly Ile Thr Ile Asn Ala Ala His
            100                 105                 110         
Val Glu Tyr Ser Thr Ala Ala Arg His Tyr Ala His Thr Asp Cys Pro
        115                 120                 125             
Gly His Ala Asp Tyr Val Lys Asn Met Ile Thr Gly Thr Ala Pro Leu
    130                 135                 140                 
Asp Gly Cys Ile Leu Val Val Ala Ala Asn Asp Gly Pro Met Pro Gln
145                 150                 155                 160 
Thr Arg Glu His Leu Leu Leu Ala Arg Gln Ile Gly Val Glu His Val
                165                 170                 175     
Val Val Tyr Val Asn Lys Ala Asp Ala Val Gln Asp Ser Glu Met Val
            180                 185                 190         
Glu Leu Val Glu Leu Glu Ile Arg Glu Leu Leu Thr Glu Phe Gly Tyr
        195                 200                 205             
Lys Gly Glu Glu Thr Pro Val Ile Val Gly Ser Ala Leu Cys Ala Leu
    210                 215                 220                 
Glu Gly Arg Asp Pro Glu Leu Gly Leu Lys Ser Val Gln Lys Leu Leu
225                 230                 235                 240 
Asp Ala Val Asp Thr Tyr Ile Pro Val Pro Ala Arg Asp Leu Glu Lys
                245                 250                 255     
Pro Phe Leu Leu Pro Val Glu Ala Val Tyr Ser Val Pro Gly Arg Gly
            260                 265                 270         
Thr Val Val Thr Gly Thr Leu Glu Arg Gly Ile Leu Lys Lys Gly Asp
        275                 280                 285             
Glu Cys Glu Leu Leu Gly His Ser Lys Asn Ile Arg Thr Val Val Thr
    290                 295                 300                 
Gly Ile Glu Met Phe His Lys Ser Leu Glu Arg Ala Glu Ala Gly Asp
305                 310                 315                 320 
Asn Leu Gly Ala Leu Val Arg Gly Leu Lys Arg Glu Asp Leu Arg Arg
                325                 330                 335     
Gly Leu Val Met Val Lys Pro Gly Ser Ile Lys Pro His Gln Lys Val
            340                 345                 350         
Glu Ala Gln Val Tyr Ile Leu Ser Lys Glu Glu Gly Gly Arg His Lys
        355                 360                 365             
Pro Phe Val Ser His Phe Met Pro Val Met Phe Ser Leu Thr Trp Asp
    370                 375                 380                 
Met Ala Cys Arg Ile Ile Leu Pro Pro Glu Lys Glu Leu Ala Met Pro
385                 390                 395                 400 
Gly Glu Asp Leu Lys Phe Asn Leu Ile Leu Arg Gln Pro Met Ile Leu
                405                 410                 415     
Glu Lys Gly Gln Arg Phe Thr Leu Arg Asp Gly Asn Arg Thr Ile Gly
            420                 425                 430         
Thr Gly Leu Val Thr Asn Thr Leu Ala Met Thr Glu Glu Glu Lys Asn
        435                 440                 445             
Ile Lys Trp Gly
    450         


<210> 225
<211> 207
<212> PRT
<213> Homo sapiens

<400> 225
Met Ser Glu Thr Val Pro Ala Ala Ser Ala Ser Ala Gly Val Ala Ala
 1               5                  10                  15      
Met Glu Lys Leu Pro Thr Lys Lys Arg Gly Arg Lys Pro Ala Gly Leu
            20                  25                  30          
Ile Ser Ala Ser Arg Lys Val Pro Asn Leu Ser Val Ser Lys Leu Ile
        35                  40                  45              
Thr Glu Ala Leu Ser Val Ser Gln Glu Arg Val Gly Met Ser Leu Val
    50                  55                  60                  
Ala Leu Lys Lys Ala Leu Ala Ala Ala Gly Tyr Asp Val Glu Lys Asn
65                  70                  75                  80  
Asn Ser Arg Ile Lys Leu Ser Leu Lys Ser Leu Val Asn Lys Gly Ile
                85                  90                  95      
Leu Val Gln Thr Arg Gly Thr Gly Ala Ser Gly Ser Phe Lys Leu Ser
            100                 105                 110         
Lys Lys Val Ile Pro Lys Ser Thr Arg Ser Lys Ala Lys Lys Ser Val
        115                 120                 125             
Ser Ala Lys Thr Lys Lys Leu Val Leu Ser Arg Asp Ser Lys Ser Pro
    130                 135                 140                 
Lys Thr Ala Lys Thr Asn Lys Arg Ala Lys Lys Pro Arg Ala Thr Thr
145                 150                 155                 160 
Pro Lys Thr Val Arg Ser Gly Arg Lys Ala Lys Gly Ala Lys Gly Lys
                165                 170                 175     
Gln Lys Gln Lys Ser Pro Val Lys Ala Arg Ala Ser Lys Ser Lys Leu
            180                 185                 190         
Thr Gln His His Glu Val Asn Val Arg Lys Ala Thr Ser Lys Lys
        195                 200                 205         


<210> 226
<211> 1360
<212> PRT
<213> Homo sapiens

<400> 226
Met Ser Arg Gln Ser Thr Leu Tyr Ser Phe Phe Pro Lys Ser Pro Ala
 1               5                  10                  15      
Leu Ser Asp Ala Asn Lys Ala Ser Ala Arg Ala Ser Arg Glu Gly Gly
            20                  25                  30          
Arg Ala Ala Ala Ala Pro Glu Ala Ser Pro Ser Pro Gly Gly Asp Ala
        35                  40                  45              
Ala Trp Ser Glu Ala Gly Pro Gly Pro Arg Pro Leu Ala Arg Ser Ala
    50                  55                  60                  
Ser Pro Pro Lys Ala Lys Asn Leu Asn Gly Gly Leu Arg Arg Ser Val
65                  70                  75                  80  
Ala Pro Ala Ala Pro Thr Ser Cys Asp Phe Ser Pro Gly Asp Leu Val
                85                  90                  95      
Trp Ala Lys Met Glu Gly Tyr Pro Trp Trp Pro Cys Leu Val Tyr Asn
            100                 105                 110         
His Pro Phe Asp Gly Thr Phe Ile Arg Glu Lys Gly Lys Ser Val Arg
        115                 120                 125             
Val His Val Gln Phe Phe Asp Asp Ser Pro Thr Arg Gly Trp Val Ser
    130                 135                 140                 
Lys Arg Leu Leu Lys Pro Tyr Thr Gly Ser Lys Ser Lys Glu Ala Gln
145                 150                 155                 160 
Lys Gly Gly His Phe Tyr Ser Ala Lys Pro Glu Ile Leu Arg Ala Met
                165                 170                 175     
Gln Arg Ala Asp Glu Ala Leu Asn Lys Asp Lys Ile Lys Arg Leu Glu
            180                 185                 190         
Leu Ala Val Cys Asp Glu Pro Ser Glu Pro Glu Glu Glu Glu Glu Met
        195                 200                 205             
Glu Val Gly Thr Thr Tyr Val Thr Asp Lys Ser Glu Glu Asp Asn Glu
    210                 215                 220                 
Ile Glu Ser Glu Glu Glu Val Gln Pro Lys Thr Gln Gly Ser Arg Arg
225                 230                 235                 240 
Ser Ser Arg Gln Ile Lys Lys Arg Arg Val Ile Ser Asp Ser Glu Ser
                245                 250                 255     
Asp Ile Gly Gly Ser Asp Val Glu Phe Lys Pro Asp Thr Lys Glu Glu
            260                 265                 270         
Gly Ser Ser Asp Glu Ile Ser Ser Gly Val Gly Asp Ser Glu Ser Glu
        275                 280                 285             
Gly Leu Asn Ser Pro Val Lys Val Ala Arg Lys Arg Lys Arg Met Val
    290                 295                 300                 
Thr Gly Asn Gly Ser Leu Lys Arg Lys Ser Ser Arg Lys Glu Thr Pro
305                 310                 315                 320 
Ser Ala Thr Lys Gln Ala Thr Ser Ile Ser Ser Glu Thr Lys Asn Thr
                325                 330                 335     
Leu Arg Ala Phe Ser Ala Pro Gln Asn Ser Glu Ser Gln Ala His Val
            340                 345                 350         
Ser Gly Gly Gly Asp Asp Ser Ser Arg Pro Thr Val Trp Tyr His Glu
        355                 360                 365             
Thr Leu Glu Trp Leu Lys Glu Glu Lys Arg Arg Asp Glu His Arg Arg
    370                 375                 380                 
Arg Pro Asp His Pro Asp Phe Asp Ala Ser Thr Leu Tyr Val Pro Glu
385                 390                 395                 400 
Asp Phe Leu Asn Ser Cys Thr Pro Gly Met Arg Lys Trp Trp Gln Ile
                405                 410                 415     
Lys Ser Gln Asn Phe Asp Leu Val Ile Cys Tyr Lys Val Gly Lys Phe
            420                 425                 430         
Tyr Glu Leu Tyr His Met Asp Ala Leu Ile Gly Val Ser Glu Leu Gly
        435                 440                 445             
Leu Val Phe Met Lys Gly Asn Trp Ala His Ser Gly Phe Pro Glu Ile
    450                 455                 460                 
Ala Phe Gly Arg Tyr Ser Asp Ser Leu Val Gln Lys Gly Tyr Lys Val
465                 470                 475                 480 
Ala Arg Val Glu Gln Thr Glu Thr Pro Glu Met Met Glu Ala Arg Cys
                485                 490                 495     
Arg Lys Met Ala His Ile Ser Lys Tyr Asp Arg Val Val Arg Arg Glu
            500                 505                 510         
Ile Cys Arg Ile Ile Thr Lys Gly Thr Gln Thr Tyr Ser Val Leu Glu
        515                 520                 525             
Gly Asp Pro Ser Glu Asn Tyr Ser Lys Tyr Leu Leu Ser Leu Lys Glu
    530                 535                 540                 
Lys Glu Glu Asp Ser Ser Gly His Thr Arg Ala Tyr Gly Val Cys Phe
545                 550                 555                 560 
Val Asp Thr Ser Leu Gly Lys Phe Phe Ile Gly Gln Phe Ser Asp Asp
                565                 570                 575     
Arg His Cys Ser Arg Phe Arg Thr Leu Val Ala His Tyr Pro Pro Val
            580                 585                 590         
Gln Val Leu Phe Glu Lys Gly Asn Leu Ser Lys Glu Thr Lys Thr Ile
        595                 600                 605             
Leu Lys Ser Ser Leu Ser Cys Ser Leu Gln Glu Gly Leu Ile Pro Gly
    610                 615                 620                 
Ser Gln Phe Trp Asp Ala Ser Lys Thr Leu Arg Thr Leu Leu Glu Glu
625                 630                 635                 640 
Glu Tyr Phe Arg Glu Lys Leu Ser Asp Gly Ile Gly Val Met Leu Pro
                645                 650                 655     
Gln Val Leu Lys Gly Met Thr Ser Glu Ser Asp Ser Ile Gly Leu Thr
            660                 665                 670         
Pro Gly Glu Lys Ser Glu Leu Ala Leu Ser Ala Leu Gly Gly Cys Val
        675                 680                 685             
Phe Tyr Leu Lys Lys Cys Leu Ile Asp Gln Glu Leu Leu Ser Met Ala
    690                 695                 700                 
Asn Phe Glu Glu Tyr Ile Pro Leu Asp Ser Asp Thr Val Ser Thr Thr
705                 710                 715                 720 
Arg Ser Gly Ala Ile Phe Thr Lys Ala Tyr Gln Arg Met Val Leu Asp
                725                 730                 735     
Ala Val Thr Leu Asn Asn Leu Glu Ile Phe Leu Asn Gly Thr Asn Gly
            740                 745                 750         
Ser Thr Glu Gly Thr Leu Leu Glu Arg Val Asp Thr Cys His Thr Pro
        755                 760                 765             
Phe Gly Lys Arg Leu Leu Lys Gln Trp Leu Cys Ala Pro Leu Cys Asn
    770                 775                 780                 
His Tyr Ala Ile Asn Asp Arg Leu Asp Ala Ile Glu Asp Leu Met Val
785                 790                 795                 800 
Val Pro Asp Lys Ile Ser Glu Val Val Glu Leu Leu Lys Lys Leu Pro
                805                 810                 815     
Asp Leu Glu Arg Leu Leu Ser Lys Ile His Asn Val Gly Ser Pro Leu
            820                 825                 830         
Lys Ser Gln Asn His Pro Asp Ser Arg Ala Ile Met Tyr Glu Glu Thr
        835                 840                 845             
Thr Tyr Ser Lys Lys Lys Ile Ile Asp Phe Leu Ser Ala Leu Glu Gly
    850                 855                 860                 
Phe Lys Val Met Cys Lys Ile Ile Gly Ile Met Glu Glu Val Ala Asp
865                 870                 875                 880 
Gly Phe Lys Ser Lys Ile Leu Lys Gln Val Ile Ser Leu Gln Thr Lys
                885                 890                 895     
Asn Pro Glu Gly Arg Phe Pro Asp Leu Thr Val Glu Leu Asn Arg Trp
            900                 905                 910         
Asp Thr Ala Phe Asp His Glu Lys Ala Arg Lys Thr Gly Leu Ile Thr
        915                 920                 925             
Pro Lys Ala Gly Phe Asp Ser Asp Tyr Asp Gln Ala Leu Ala Asp Ile
    930                 935                 940                 
Arg Glu Asn Glu Gln Ser Leu Leu Glu Tyr Leu Glu Lys Gln Arg Asn
945                 950                 955                 960 
Arg Ile Gly Cys Arg Thr Ile Val Tyr Trp Gly Ile Gly Arg Asn Arg
                965                 970                 975     
Tyr Gln Leu Glu Ile Pro Glu Asn Phe Thr Thr Arg Asn Leu Pro Glu
            980                 985                 990         
Glu Tyr Glu Leu Lys Ser Thr Lys Lys Gly Cys Lys Arg Tyr Trp Thr
        995                 1000                1005            
Lys Thr Ile Glu Lys Lys Leu Ala Asn Leu Ile Asn Ala Glu Glu Arg
    1010                1015                1020                
Arg Asp Val Ser Leu Lys Asp Cys Met Arg Arg Leu Phe Tyr Asn Phe
1025                1030                1035                1040
Asp Lys Asn Tyr Lys Asp Trp Gln Ser Ala Val Glu Cys Ile Ala Val
                1045                1050                1055    
Leu Asp Val Leu Leu Cys Leu Ala Asn Tyr Ser Arg Gly Gly Asp Gly
            1060                1065                1070        
Pro Met Cys Arg Pro Val Ile Leu Leu Pro Glu Asp Thr Pro Pro Phe
        1075                1080                1085            
Leu Glu Leu Lys Gly Ser Arg His Pro Cys Ile Thr Lys Thr Phe Phe
    1090                1095                1100                
Gly Asp Asp Phe Ile Pro Asn Asp Ile Leu Ile Gly Cys Glu Glu Glu
1105                1110                1115                1120
Glu Gln Glu Asn Gly Lys Ala Tyr Cys Val Leu Val Thr Gly Pro Asn
                1125                1130                1135    
Met Gly Gly Lys Ser Thr Leu Met Arg Gln Ala Gly Leu Leu Ala Val
            1140                1145                1150        
Met Ala Gln Met Gly Cys Tyr Val Pro Ala Glu Val Cys Arg Leu Thr
        1155                1160                1165            
Pro Ile Asp Arg Val Phe Thr Arg Leu Gly Ala Ser Asp Arg Ile Met
    1170                1175                1180                
Ser Gly Glu Ser Thr Phe Phe Val Glu Leu Ser Glu Thr Ala Ser Ile
1185                1190                1195                1200
Leu Met His Ala Thr Ala His Ser Leu Val Leu Val Asp Glu Leu Gly
                1205                1210                1215    
Arg Gly Thr Ala Thr Phe Asp Gly Thr Ala Ile Ala Asn Ala Val Val
            1220                1225                1230        
Lys Glu Leu Ala Glu Thr Ile Lys Cys Arg Thr Leu Phe Ser Thr His
        1235                1240                1245            
Tyr His Ser Leu Val Glu Asp Tyr Ser Gln Asn Val Ala Val Arg Leu
    1250                1255                1260                
Gly His Met Ala Cys Met Val Glu Asn Glu Cys Glu Asp Pro Ser Gln
1265                1270                1275                1280
Glu Thr Ile Thr Phe Leu Tyr Lys Phe Ile Lys Gly Ala Cys Pro Lys
                1285                1290                1295    
Ser Tyr Gly Phe Asn Ala Ala Arg Leu Ala Asn Leu Pro Glu Glu Val
            1300                1305                1310        
Ile Gln Lys Gly His Arg Lys Ala Arg Glu Phe Glu Lys Met Asn Gln
        1315                1320                1325            
Ser Leu Arg Leu Phe Arg Glu Val Cys Leu Ala Ser Glu Arg Ser Thr
    1330                1335                1340                
Val Asp Ala Glu Ala Val His Lys Leu Leu Thr Leu Ile Lys Glu Leu
1345                1350                1355                1360


<210> 227
<211> 1178
<212> PRT
<213> Homo sapiens

<400> 227
Met Leu Lys Phe Arg Thr Val His Gly Gly Leu Arg Leu Leu Gly Ile
 1               5                  10                  15      
Arg Arg Thr Ser Thr Ala Pro Ala Ala Ser Pro Asn Val Arg Arg Leu
            20                  25                  30          
Glu Tyr Lys Pro Ile Lys Lys Val Met Val Ala Asn Arg Gly Glu Ile
        35                  40                  45              
Ala Ile Arg Val Phe Arg Ala Cys Thr Glu Leu Gly Ile Arg Thr Val
    50                  55                  60                  
Ala Ile Tyr Ser Glu Gln Asp Thr Gly Gln Met His Arg Gln Lys Ala
65                  70                  75                  80  
Asp Glu Ala Tyr Leu Ile Gly Arg Gly Leu Ala Pro Val Gln Ala Tyr
                85                  90                  95      
Leu His Ile Pro Asp Ile Ile Lys Val Ala Lys Glu Asn Asn Val Asp
            100                 105                 110         
Ala Val His Pro Gly Tyr Gly Phe Leu Ser Glu Arg Ala Asp Phe Ala
        115                 120                 125             
Gln Ala Cys Gln Asp Ala Gly Val Arg Phe Ile Gly Pro Ser Pro Glu
    130                 135                 140                 
Val Val Arg Lys Met Gly Asp Lys Val Glu Ala Arg Ala Ile Ala Ile
145                 150                 155                 160 
Ala Ala Gly Val Pro Val Val Pro Gly Thr Asp Ala Pro Ile Thr Ser
                165                 170                 175     
Leu His Glu Ala His Glu Phe Ser Asn Thr Tyr Gly Phe Pro Ile Ile
            180                 185                 190         
Phe Lys Ala Ala Tyr Gly Gly Gly Gly Arg Gly Met Arg Val Val His
        195                 200                 205             
Ser Tyr Glu Glu Leu Glu Glu Asn Tyr Thr Arg Ala Tyr Ser Glu Ala
    210                 215                 220                 
Leu Ala Ala Phe Gly Asn Gly Ala Leu Phe Val Glu Lys Phe Ile Glu
225                 230                 235                 240 
Lys Pro Arg His Ile Glu Val Gln Ile Leu Gly Asp Gln Tyr Gly Asn
                245                 250                 255     
Ile Leu His Leu Tyr Glu Arg Asp Cys Ser Ile Gln Arg Arg His Gln
            260                 265                 270         
Lys Val Val Glu Ile Ala Pro Ala Ala His Leu Asp Pro Gln Leu Arg
        275                 280                 285             
Thr Arg Leu Thr Ser Asp Ser Val Lys Leu Ala Lys Gln Val Gly Tyr
    290                 295                 300                 
Glu Asn Ala Gly Thr Val Glu Phe Leu Val Asp Arg His Gly Lys His
305                 310                 315                 320 
Tyr Phe Ile Glu Val Asn Ser Arg Leu Gln Val Glu His Thr Val Thr
                325                 330                 335     
Glu Glu Ile Thr Asp Val Asp Leu Val His Ala Gln Ile His Val Ala
            340                 345                 350         
Glu Gly Arg Ser Leu Pro Asp Leu Gly Leu Arg Gln Glu Asn Ile Arg
        355                 360                 365             
Ile Asn Gly Cys Ala Ile Gln Cys Arg Val Thr Thr Glu Asp Pro Ala
    370                 375                 380                 
Arg Ser Phe Gln Pro Asp Thr Gly Arg Ile Glu Val Phe Arg Ser Gly
385                 390                 395                 400 
Glu Gly Met Gly Ile Arg Leu Asp Asn Ala Ser Ala Phe Gln Gly Ala
                405                 410                 415     
Val Ile Ser Pro His Tyr Asp Ser Leu Leu Val Lys Val Ile Ala His
            420                 425                 430         
Gly Lys Asp His Pro Thr Ala Ala Thr Lys Met Ser Arg Ala Leu Ala
        435                 440                 445             
Glu Phe Arg Val Arg Gly Val Lys Thr Asn Ile Ala Phe Leu Gln Asn
    450                 455                 460                 
Val Leu Asn Asn Gln Gln Phe Leu Ala Gly Thr Val Asp Thr Gln Phe
465                 470                 475                 480 
Ile Asp Glu Asn Pro Glu Leu Phe Gln Leu Arg Pro Ala Gln Asn Arg
                485                 490                 495     
Ala Gln Lys Leu Leu His Tyr Leu Gly His Val Met Val Asn Gly Pro
            500                 505                 510         
Thr Thr Pro Ile Pro Val Lys Ala Ser Pro Ser Pro Thr Asp Pro Val
        515                 520                 525             
Val Pro Ala Val Pro Ile Gly Pro Pro Pro Ala Gly Phe Arg Asp Ile
    530                 535                 540                 
Leu Leu Arg Glu Gly Pro Glu Gly Phe Ala Arg Ala Val Arg Asn His
545                 550                 555                 560 
Pro Gly Leu Leu Leu Met Asp Thr Thr Phe Arg Asp Ala His Gln Ser
                565                 570                 575     
Leu Leu Ala Thr Arg Val Arg Thr His Asp Leu Lys Lys Ile Ala Pro
            580                 585                 590         
Tyr Val Ala His Asn Phe Ser Lys Leu Phe Ser Met Glu Asn Trp Gly
        595                 600                 605             
Gly Ala Thr Phe Asp Val Ala Met Arg Phe Leu Tyr Glu Cys Pro Trp
    610                 615                 620                 
Arg Arg Leu Gln Glu Leu Arg Glu Leu Ile Pro Asn Ile Pro Phe Gln
625                 630                 635                 640 
Met Leu Leu Arg Gly Ala Asn Ala Val Gly Tyr Thr Asn Tyr Pro Asp
                645                 650                 655     
Asn Val Val Phe Lys Phe Cys Glu Val Ala Lys Glu Asn Gly Met Asp
            660                 665                 670         
Val Phe Arg Val Phe Asp Ser Leu Asn Tyr Leu Pro Asn Met Leu Leu
        675                 680                 685             
Gly Met Glu Ala Ala Gly Ser Ala Gly Gly Val Val Glu Ala Ala Ile
    690                 695                 700                 
Ser Tyr Thr Gly Asp Val Ala Asp Pro Ser Arg Thr Lys Tyr Ser Leu
705                 710                 715                 720 
Gln Tyr Tyr Met Gly Leu Ala Glu Glu Leu Val Arg Ala Gly Thr His
                725                 730                 735     
Ile Leu Cys Ile Lys Asp Met Ala Gly Leu Leu Lys Pro Thr Ala Cys
            740                 745                 750         
Thr Met Leu Val Ser Ser Leu Arg Asp Arg Phe Pro Asp Leu Pro Leu
        755                 760                 765             
His Ile His Thr His Asp Thr Ser Gly Ala Gly Val Ala Ala Met Leu
    770                 775                 780                 
Ala Cys Ala Gln Ala Gly Ala Asp Val Val Asp Val Ala Ala Asp Ser
785                 790                 795                 800 
Met Ser Gly Met Thr Ser Gln Pro Ser Met Gly Ala Leu Val Ala Cys
                805                 810                 815     
Thr Arg Gly Thr Pro Leu Asp Thr Glu Val Pro Met Glu Arg Val Phe
            820                 825                 830         
Asp Tyr Ser Glu Tyr Trp Glu Gly Ala Arg Gly Leu Tyr Ala Ala Phe
        835                 840                 845             
Asp Cys Thr Ala Thr Met Lys Ser Gly Asn Ser Asp Val Tyr Glu Asn
    850                 855                 860                 
Glu Ile Pro Gly Gly Gln Tyr Thr Asn Leu His Phe Gln Ala His Ser
865                 870                 875                 880 
Met Gly Leu Gly Ser Lys Phe Lys Glu Val Lys Lys Ala Tyr Val Glu
                885                 890                 895     
Ala Asn Gln Met Leu Gly Asp Leu Ile Lys Val Thr Pro Ser Ser Lys
            900                 905                 910         
Ile Val Gly Asp Leu Ala Gln Phe Met Val Gln Asn Gly Leu Ser Arg
        915                 920                 925             
Ala Glu Ala Glu Ala Gln Ala Glu Glu Leu Ser Phe Pro Arg Ser Val
    930                 935                 940                 
Val Glu Phe Leu Gln Gly Tyr Ile Gly Val Pro His Gly Gly Phe Pro
945                 950                 955                 960 
Glu Pro Phe Arg Ser Lys Val Leu Lys Asp Leu Pro Arg Val Glu Gly
                965                 970                 975     
Arg Pro Gly Ala Ser Leu Pro Pro Leu Asp Leu Gln Ala Leu Glu Lys
            980                 985                 990         
Glu Leu Val Asp Arg His Gly Glu Glu Val Thr Pro Glu Asp Val Leu
        995                 1000                1005            
Ser Ala Ala Met Tyr Pro Asp Val Phe Ala His Phe Lys Asp Phe Thr
    1010                1015                1020                
Ala Thr Phe Gly Pro Leu Asp Ser Leu Asn Thr Arg Leu Phe Leu Gln
1025                1030                1035                1040
Gly Pro Lys Ile Ala Glu Glu Phe Glu Val Glu Leu Glu Arg Gly Lys
                1045                1050                1055    
Thr Leu His Ile Lys Ala Leu Ala Val Ser Asp Leu Asn Arg Ala Gly
            1060                1065                1070        
Gln Arg Gln Val Phe Phe Glu Leu Asn Gly Gln Leu Arg Ser Ile Leu
        1075                1080                1085            
Val Lys Asp Thr Gln Ala Met Lys Glu Met His Phe His Pro Lys Ala
    1090                1095                1100                
Leu Lys Asp Val Lys Gly Gln Ile Gly Ala Pro Met Pro Gly Lys Val
1105                1110                1115                1120
Ile Asp Ile Lys Val Val Ala Gly Ala Lys Val Ala Lys Gly Gln Pro
                1125                1130                1135    
Leu Cys Val Leu Ser Ala Met Lys Met Glu Thr Val Val Thr Ser Pro
            1140                1145                1150        
Met Glu Gly Thr Val Arg Lys Val His Val Thr Lys Asp Met Thr Leu
        1155                1160                1165            
Glu Gly Asp Asp Leu Ile Leu Glu Ile Glu
    1170                1175            


<210> 228
<211> 375
<212> PRT
<213> Homo sapiens

<400> 228
Leu Ile Gly Leu Ile Val Glu Glu Gly Glu Asp Trp Lys His Val Glu
 1               5                  10                  15      
Ile Pro Lys Asp Val Gly Pro Pro Pro Pro Val Ser Lys Pro Ser Glu
            20                  25                  30          
Pro Arg Pro Ser Pro Glu Pro Gln Ile Ser Ile Pro Val Lys Lys Glu
        35                  40                  45              
His Ile Pro Gly Thr Leu Arg Phe Arg Leu Ser Pro Ala Ala Arg Asn
    50                  55                  60                  
Ile Leu Glu Lys His Ser Leu Asp Ala Ser Gln Gly Thr Ala Thr Gly
65                  70                  75                  80  
Pro Arg Gly Ile Phe Thr Lys Glu Asp Ala Leu Lys Leu Val Gln Leu
                85                  90                  95      
Lys Gln Thr Gly Lys Ile Thr Glu Ser Arg Pro Thr Pro Ala Pro Thr
            100                 105                 110         
Ala Thr Pro Thr Ala Pro Ser Pro Leu Gln Ala Thr Ala Gly Pro Ser
        115                 120                 125             
Tyr Pro Arg Pro Val Ile Pro Pro Val Ser Thr Pro Gly Gln Pro Asn
    130                 135                 140                 
Ala Val Gly Thr Phe Thr Glu Ile Pro Ala Ser Asn Ile Arg Arg Val
145                 150                 155                 160 
Ile Ala Lys Arg Leu Thr Glu Ser Lys Ser Thr Val Pro His Ala Tyr
                165                 170                 175     
Ala Thr Ala Asp Cys Asp Leu Gly Ala Val Leu Lys Val Arg Gln Asp
            180                 185                 190         
Leu Val Lys Asp Asp Ile Lys Val Ser Val Asn Asp Phe Ile Ile Lys
        195                 200                 205             
Ala Ala Ala Val Thr Leu Lys Gln Met Pro Asp Val Asn Val Ser Trp
    210                 215                 220                 
Asp Gly Glu Gly Pro Lys Gln Leu Pro Phe Ile Asp Ile Ser Val Ala
225                 230                 235                 240 
Val Ala Thr Asp Lys Gly Leu Leu Thr Pro Ile Ile Lys Asp Ala Ala
                245                 250                 255     
Ala Lys Gly Ile Gln Glu Ile Ala Asp Ser Val Lys Ala Leu Ser Lys
            260                 265                 270         
Lys Ala Arg Asp Gly Lys Leu Leu Pro Glu Glu Tyr Gln Gly Gly Ser
        275                 280                 285             
Phe Ser Ile Ser Asn Leu Gly Met Phe Gly Ile Asp Glu Phe Thr Ala
    290                 295                 300                 
Val Ile Asn Pro Pro Gln Ala Cys Ile Leu Ala Val Gly Arg Phe Arg
305                 310                 315                 320 
Pro Val Leu Lys Leu Thr Glu Asp Glu Glu Gly Asn Ala Lys Leu Gln
                325                 330                 335     
Gln Arg Gln Leu Ile Thr Val Thr Met Ser Ser Asp Ser Arg Val Val
            340                 345                 350         
Asp Asp Glu Leu Ala Thr Arg Phe Leu Lys Ser Phe Lys Ala Asn Leu
        355                 360                 365             
Glu Asn Pro Ile Arg Leu Ala
    370                 375 


<210> 229
<211> 780
<212> PRT
<213> Homo sapiens

<400> 229
Met Ala Pro Tyr Ser Leu Leu Val Thr Arg Leu Gln Lys Ala Leu Gly
 1               5                  10                  15      
Val Arg Gln Tyr His Val Ala Ser Val Leu Cys Gln Arg Ala Lys Val
            20                  25                  30          
Ala Met Thr His Phe Glu Pro Asn Glu Tyr Ile His Tyr Asp Leu Leu
        35                  40                  45              
Glu Lys Asn Ile Asn Ile Val Arg Lys Arg Leu Asn Arg Pro Leu Thr
    50                  55                  60                  
Leu Ser Glu Lys Ile Val Tyr Gly His Leu Asp Asp Pro Ala Ser Gln
65                  70                  75                  80  
Glu Ile Glu Arg Gly Lys Ser Tyr Leu Arg Leu Arg Pro Asp Arg Val
                85                  90                  95      
Ala Met Gln Asp Ala Thr Ala Gln Met Ala Met Leu Gln Phe Ile Ser
            100                 105                 110         
Ser Gly Leu Ser Lys Val Ala Val Pro Ser Thr Ile His Cys Asp His
        115                 120                 125             
Leu Ile Glu Ala Gln Val Gly Asp Glu Lys Asp Leu Arg Arg Ala Lys
    130                 135                 140                 
Asp Ile Asn Gln Glu Val Tyr Asn Phe Leu Ala Thr Ala Gly Asp Lys
145                 150                 155                 160 
Tyr Gly Val Gly Phe Trp Ser Pro Gly Ser Gly Ile Ile His Gln Ile
                165                 170                 175     
Ile Leu Glu Asn Tyr Ala Tyr Pro Gly Val Leu Leu Ile Gly Thr Asp
            180                 185                 190         
Ser His Thr Pro Asn Gly Gly Gly Leu Gly Gly Ile Cys Ile Gly Val
        195                 200                 205             
Gly Gly Ala Asp Ala Val Asp Val Met Ala Gly Ile Pro Trp Glu Leu
    210                 215                 220                 
Lys Cys Pro Lys Val Ile Gly Val Lys Leu Thr Gly Ser Leu Ser Gly
225                 230                 235                 240 
Trp Thr Ser Pro Lys Asp Val Ile Leu Lys Val Ala Gly Ile Leu Thr
                245                 250                 255     
Val Lys Gly Gly Thr Gly Ala Ile Val Glu Tyr His Gly Pro Gly Val
            260                 265                 270         
Asp Ser Met Ser Cys Thr Gly Met Ala Thr Ile Cys Asn Met Gly Ala
        275                 280                 285             
Glu Ile Gly Ala Thr Thr Ser Val Phe Pro Tyr Asn His Arg Met Lys
    290                 295                 300                 
Lys Tyr Leu Ser Lys Thr Gly Arg Glu Asp Ile Ala Asn Leu Ala Asp
305                 310                 315                 320 
Glu Phe Lys Asp His Leu Val Pro Asp Pro Gly Cys His Tyr Asp Gln
                325                 330                 335     
Leu Ile Glu Ile Asn Leu Ser Glu Leu Lys Pro His Ile Asn Gly Pro
            340                 345                 350         
Phe Thr Pro Asp Leu Ala His Pro Val Ala Glu Val Gly Lys Val Ala
        355                 360                 365             
Glu Lys Glu Gly Trp Pro Leu Asp Ile Arg Val Gly Leu Ile Gly Ser
    370                 375                 380                 
Cys Thr Asn Ser Ser Tyr Glu Asp Met Gly Arg Ser Ala Ala Val Ala
385                 390                 395                 400 
Lys Gln Ala Leu Ala His Gly Leu Lys Cys Lys Ser Gln Phe Thr Ile
                405                 410                 415     
Thr Pro Gly Ser Glu Gln Ile Arg Ala Thr Ile Glu Arg Asp Gly Tyr
            420                 425                 430         
Ala Gln Ile Leu Arg Asp Leu Gly Gly Ile Val Leu Ala Asn Ala Cys
        435                 440                 445             
Gly Pro Cys Ile Gly Gln Trp Asp Arg Lys Asp Ile Lys Lys Gly Glu
    450                 455                 460                 
Lys Asn Thr Ile Val Thr Ser Tyr Asn Arg Asn Phe Thr Gly Arg Asn
465                 470                 475                 480 
Asp Ala Asn Pro Glu Thr His Ala Phe Val Thr Ser Pro Glu Ile Val
                485                 490                 495     
Thr Ala Leu Ala Ile Ala Gly Thr Leu Lys Phe Asn Pro Glu Thr Asp
            500                 505                 510         
Tyr Leu Thr Gly Lys Asp Gly Lys Lys Phe Arg Leu Glu Ala Pro Asp
        515                 520                 525             
Ala Asp Glu Leu Pro Lys Gly Glu Phe Asp Pro Gly Gln Asp Thr Tyr
    530                 535                 540                 
Gln His Pro Pro Lys Asp Ser Ser Arg Gln His Val Asp Val Ser Pro
545                 550                 555                 560 
Thr Ser Gln Arg Leu Gln Leu Leu Glu Pro Phe Asp Lys Trp Asp Gly
                565                 570                 575     
Lys Asp Leu Glu Asp Leu Gln Ile Leu Ile Lys Val Lys Gly Lys Cys
            580                 585                 590         
Thr Thr Asp His Ile Ser Ala Ala Gly Pro Trp Leu Lys Phe Arg Gly
        595                 600                 605             
His Leu Asp Asn Ile Ser Asn Asn Leu Leu Ile Gly Ala Ile Asn Ile
    610                 615                 620                 
Glu Asn Gly Lys Ala Asn Ser Val Arg Asn Ala Val Thr Gln Glu Phe
625                 630                 635                 640 
Gly Pro Val Pro Asp Thr Ala Arg Tyr Tyr Lys Lys His Gly Ile Arg
                645                 650                 655     
Trp Val Val Ile Gly Asp Glu Asn Tyr Gly Glu Gly Ser Ser Arg Glu
            660                 665                 670         
His Ala Ala Leu Glu Pro Arg His Leu Gly Gly Arg Ala Ile Ile Thr
        675                 680                 685             
Lys Ser Phe Ala Arg Ile His Glu Thr Asn Leu Lys Lys Gln Gly Leu
    690                 695                 700                 
Leu Pro Leu Thr Phe Ala Asp Pro Ala Asp Tyr Asn Lys Ile His Pro
705                 710                 715                 720 
Val Asp Lys Leu Thr Ile Gln Gly Leu Lys Asp Phe Thr Pro Gly Lys
                725                 730                 735     
Pro Leu Lys Cys Ile Ile Lys His Pro Asn Gly Thr Gln Glu Thr Ile
            740                 745                 750         
Leu Leu Asn His Thr Phe Asn Glu Thr Gln Ile Glu Trp Phe Arg Ala
        755                 760                 765             
Gly Ser Ala Leu Asn Arg Met Lys Glu Leu Gln Gln
    770                 775                 780 


<210> 230
<211> 780
<212> PRT
<213> Homo sapiens

<400> 230
Met Ala Pro Tyr Ser Leu Leu Val Thr Arg Leu Gln Lys Ala Leu Gly
 1               5                  10                  15      
Val Arg Gln Tyr His Val Ala Ser Val Leu Cys Gln Arg Ala Lys Val
            20                  25                  30          
Ala Met Thr His Phe Glu Pro Asn Glu Tyr Ile His Tyr Asp Leu Leu
        35                  40                  45              
Glu Lys Asn Ile Asn Ile Val Arg Lys Arg Leu Asn Arg Pro Leu Thr
    50                  55                  60                  
Leu Ser Glu Lys Ile Val Tyr Gly His Leu Asp Asp Pro Ala Ser Gln
65                  70                  75                  80  
Glu Ile Glu Arg Gly Lys Ser Tyr Leu Arg Leu Arg Pro Asp Arg Val
                85                  90                  95      
Ala Met Gln Asp Ala Thr Ala Gln Met Ala Met Leu Gln Phe Ile Ser
            100                 105                 110         
Ser Gly Leu Ser Lys Val Ala Val Pro Ser Thr Ile His Cys Asp His
        115                 120                 125             
Leu Ile Glu Ala Gln Val Gly Asp Glu Lys Asp Leu Arg Arg Ala Lys
    130                 135                 140                 
Asp Ile Asn Gln Glu Val Tyr Asn Phe Leu Ala Thr Ala Gly Asp Lys
145                 150                 155                 160 
Tyr Gly Val Gly Phe Trp Ser Pro Gly Ser Gly Ile Ile His Gln Ile
                165                 170                 175     
Ile Leu Glu Asn Tyr Ala Tyr Pro Gly Val Leu Leu Ile Gly Thr Asp
            180                 185                 190         
Ser His Thr Pro Asn Gly Gly Gly Leu Gly Gly Ile Cys Ile Gly Val
        195                 200                 205             
Gly Gly Ala Asp Ala Val Asp Val Met Ala Gly Ile Pro Trp Glu Leu
    210                 215                 220                 
Lys Cys Pro Lys Val Ile Gly Val Lys Leu Thr Gly Ser Leu Ser Gly
225                 230                 235                 240 
Trp Thr Ser Pro Lys Asp Val Ile Leu Lys Val Ala Gly Ile Leu Thr
                245                 250                 255     
Val Lys Gly Gly Thr Gly Ala Ile Val Glu Tyr His Gly Pro Gly Val
            260                 265                 270         
Asp Ser Met Ser Cys Thr Gly Met Ala Thr Ile Cys Asn Met Gly Ala
        275                 280                 285             
Glu Ile Gly Ala Thr Thr Ser Val Phe Pro Tyr Asn His Arg Met Lys
    290                 295                 300                 
Lys Tyr Leu Ser Lys Thr Gly Arg Glu Asp Ile Ala Asn Leu Ala Asp
305                 310                 315                 320 
Glu Phe Lys Asp His Leu Val Pro Asp Pro Gly Cys His Tyr Asp Gln
                325                 330                 335     
Leu Ile Glu Ile Asn Leu Ser Glu Leu Lys Pro His Ile Asn Gly Pro
            340                 345                 350         
Phe Thr Pro Asp Leu Ala His Pro Val Ala Glu Val Gly Lys Val Ala
        355                 360                 365             
Glu Lys Glu Gly Trp Pro Leu Asp Ile Arg Val Gly Leu Ile Gly Ser
    370                 375                 380                 
Cys Thr Asn Ser Ser Tyr Glu Asp Met Gly Arg Ser Ala Ala Val Ala
385                 390                 395                 400 
Lys Gln Ala Leu Ala His Gly Leu Lys Cys Lys Ser Gln Phe Thr Ile
                405                 410                 415     
Thr Pro Gly Ser Glu Gln Ile Arg Ala Thr Ile Glu Arg Asp Gly Tyr
            420                 425                 430         
Ala Gln Ile Leu Arg Asp Leu Gly Gly Ile Val Leu Ala Asn Ala Cys
        435                 440                 445             
Gly Pro Cys Ile Gly Gln Trp Asp Arg Lys Asp Ile Lys Lys Gly Glu
    450                 455                 460                 
Lys Asn Thr Ile Val Thr Ser Tyr Asn Arg Asn Phe Thr Gly Arg Asn
465                 470                 475                 480 
Asp Ala Asn Pro Glu Thr His Ala Phe Val Thr Ser Pro Glu Ile Val
                485                 490                 495     
Thr Ala Leu Ala Ile Ala Gly Thr Leu Lys Phe Asn Pro Glu Thr Asp
            500                 505                 510         
Tyr Leu Thr Gly Lys Asp Gly Lys Lys Phe Arg Leu Glu Ala Pro Asp
        515                 520                 525             
Ala Asp Glu Leu Pro Lys Gly Glu Phe Asp Pro Gly Gln Asp Thr Tyr
    530                 535                 540                 
Gln His Pro Pro Lys Asp Ser Ser Arg Gln His Val Asp Val Ser Pro
545                 550                 555                 560 
Thr Ser Gln Arg Leu Gln Leu Leu Glu Pro Phe Asp Lys Trp Asp Gly
                565                 570                 575     
Lys Asp Leu Glu Asp Leu Gln Ile Leu Ile Lys Val Lys Gly Lys Cys
            580                 585                 590         
Thr Thr Asp His Ile Ser Ala Ala Gly Pro Trp Leu Lys Phe Arg Gly
        595                 600                 605             
His Leu Asp Asn Ile Ser Asn Asn Leu Leu Ile Gly Ala Ile Asn Ile
    610                 615                 620                 
Glu Asn Gly Lys Ala Asn Ser Val Arg Asn Ala Val Thr Gln Glu Phe
625                 630                 635                 640 
Gly Pro Val Pro Asp Thr Ala Arg Tyr Tyr Lys Lys His Gly Ile Arg
                645                 650                 655     
Trp Val Val Ile Gly Asp Glu Asn Tyr Gly Glu Gly Ser Ser Arg Glu
            660                 665                 670         
His Ala Ala Leu Glu Pro Arg His Leu Gly Gly Arg Ala Ile Ile Thr
        675                 680                 685             
Lys Ser Phe Ala Arg Ile His Glu Thr Asn Leu Lys Lys Gln Gly Leu
    690                 695                 700                 
Leu Pro Leu Thr Phe Ala Asp Pro Ala Asp Tyr Asn Lys Ile His Pro
705                 710                 715                 720 
Val Asp Lys Leu Thr Ile Gln Gly Leu Lys Asp Phe Thr Pro Gly Lys
                725                 730                 735     
Pro Leu Lys Cys Ile Ile Lys His Pro Asn Gly Thr Gln Glu Thr Ile
            740                 745                 750         
Leu Leu Asn His Thr Phe Asn Glu Thr Gln Ile Glu Trp Phe Arg Ala
        755                 760                 765             
Gly Ser Ala Leu Asn Arg Met Lys Glu Leu Gln Gln
    770                 775                 780 


<210> 231
<211> 1273
<212> PRT
<213> Homo sapiens

<400> 231
Met Pro Cys Phe Tyr Leu Arg Ser Cys Gly Ser Leu Leu Pro Glu Leu
 1               5                  10                  15      
Lys Leu Glu Glu Arg Thr Glu Phe Ala His Arg Ile Trp Asp Thr Leu
            20                  25                  30          
Gln Lys Leu Gly Ala Val Tyr Asp Val Ser His Tyr Asn Ala Leu Leu
        35                  40                  45              
Lys Val Tyr Leu Gln Asn Glu Tyr Lys Phe Ser Pro Thr Asp Phe Leu
    50                  55                  60                  
Ala Lys Met Glu Glu Ala Asn Ile Gln Pro Asn Arg Val Thr Tyr Gln
65                  70                  75                  80  
Arg Leu Ile Ala Ser Tyr Cys Asn Val Gly Asp Ile Glu Gly Ala Ser
                85                  90                  95      
Lys Ile Leu Gly Phe Met Lys Thr Lys Asp Leu Pro Val Thr Glu Ala
            100                 105                 110         
Val Phe Ser Ala Leu Val Thr Gly His Ala Arg Ala Gly Asp Met Glu
        115                 120                 125             
Asn Ala Glu Asn Ile Leu Thr Val Met Arg Asp Ala Gly Ile Glu Pro
    130                 135                 140                 
Gly Pro Asp Thr Tyr Leu Ala Leu Leu Asn Ala Tyr Ala Glu Lys Gly
145                 150                 155                 160 
Asp Ile Asp His Val Lys Gln Thr Leu Glu Lys Val Glu Lys Phe Glu
                165                 170                 175     
Leu His Leu Met Asp Arg Asp Leu Leu Gln Ile Ile Phe Ser Phe Ser
            180                 185                 190         
Lys Ala Gly Tyr Leu Ser Met Ser Gln Lys Phe Trp Lys Lys Phe Thr
        195                 200                 205             
Cys Glu Arg Arg Tyr Ile Pro Asp Ala Met Asn Leu Ile Leu Leu Leu
    210                 215                 220                 
Val Thr Glu Lys Leu Glu Asp Val Ala Leu Gln Ile Leu Leu Ala Cys
225                 230                 235                 240 
Pro Val Ser Lys Glu Asp Gly Pro Ser Val Phe Gly Ser Phe Phe Leu
                245                 250                 255     
Gln His Cys Val Thr Met Asn Thr Pro Val Glu Lys Leu Thr Asp Tyr
            260                 265                 270         
Cys Lys Lys Leu Lys Glu Val Gln Met His Ser Phe Pro Leu Gln Phe
        275                 280                 285             
Thr Leu His Cys Ala Leu Leu Ala Asn Lys Thr Asp Leu Ala Lys Ala
    290                 295                 300                 
Leu Met Lys Ala Val Lys Glu Glu Gly Phe Pro Ile Arg Pro His Tyr
305                 310                 315                 320 
Phe Trp Pro Leu Leu Val Gly Arg Arg Lys Glu Lys Asn Val Gln Gly
                325                 330                 335     
Ile Ile Glu Ile Leu Lys Gly Met Gln Glu Leu Gly Val His Pro Asp
            340                 345                 350         
Gln Glu Thr Tyr Thr Asp Tyr Val Ile Pro Cys Phe Asp Ser Val Asn
        355                 360                 365             
Ser Ala Arg Ala Ile Leu Gln Glu Asn Gly Cys Leu Ser Asp Ser Asp
    370                 375                 380                 
Met Phe Ser Gln Ala Gly Leu Arg Ser Glu Ala Ala Asn Gly Asn Leu
385                 390                 395                 400 
Asp Phe Val Leu Ser Phe Leu Lys Ser Asn Thr Leu Pro Ile Ser Leu
                405                 410                 415     
Gln Ser Ile Arg Ser Ser Leu Leu Leu Gly Phe Arg Arg Ser Met Asn
            420                 425                 430         
Ile Asn Val Trp Ser Glu Ile Thr Glu Leu Leu Tyr Lys Asp Gly Arg
        435                 440                 445             
Tyr Cys Gln Glu Pro Arg Gly Pro Thr Glu Ala Val Gly Asn Phe Leu
    450                 455                 460                 
Tyr Asn Leu Ile Asp Ser Met Ser Asp Ser Glu Val Gln Ala Lys Glu
465                 470                 475                 480 
Glu His Leu Arg Gln Tyr Phe His Gln Leu Glu Lys Met Asn Val Lys
                485                 490                 495     
Ile Pro Glu Asn Ile Tyr Arg Gly Ile Arg Asn Leu Leu Glu Ser Tyr
            500                 505                 510         
His Val Pro Glu Leu Ile Lys Asp Ala His Leu Leu Val Glu Arg Lys
        515                 520                 525             
Asn Leu Asp Phe Gln Lys Thr Val Gln Leu Thr Ser Ser Glu Leu Glu
    530                 535                 540                 
Ser Thr Leu Glu Thr Leu Lys Ala Glu Asn Gln Pro Ile Arg Asp Val
545                 550                 555                 560 
Leu Lys Gln Leu Ile Leu Val Leu Cys Ser Glu Glu Asn Met Gln Lys
                565                 570                 575     
Ala Leu Glu Leu Lys Ala Lys Tyr Glu Ser Asp Met Val Thr Gly Gly
            580                 585                 590         
Tyr Ala Ala Leu Ile Asn Leu Cys Cys Arg His Asp Lys Val Glu Asp
        595                 600                 605             
Ala Leu Asn Leu Lys Glu Glu Phe Asp Arg Leu Asp Ser Ser Ala Val
    610                 615                 620                 
Leu Asp Thr Gly Asn Tyr Leu Gly Leu Val Arg Val Leu Ala Lys His
625                 630                 635                 640 
Gly Lys Leu Gln Asp Ala Ile Lys Ile Leu Lys Glu Met Lys Glu Lys
                645                 650                 655     
Asp Val Leu Ile Lys Asp Thr Thr Ala Leu Ser Phe Phe His Met Leu
            660                 665                 670         
Asn Gly Ala Ala Leu Arg Gly Glu Ile Glu Thr Val Lys Gln Leu His
        675                 680                 685             
Glu Ala Ile Val Thr Leu Gly Leu Ala Glu Pro Ser Thr Asn Ile Ser
    690                 695                 700                 
Phe Pro Leu Val Thr Val His Leu Glu Lys Gly Asp Leu Ser Thr Ala
705                 710                 715                 720 
Leu Glu Val Ala Ile Asp Cys Tyr Glu Lys Tyr Lys Val Leu Pro Arg
                725                 730                 735     
Ile His Asp Val Leu Cys Lys Leu Val Glu Lys Gly Glu Thr Asp Leu
            740                 745                 750         
Ile Gln Lys Ala Met Asp Phe Val Ser Gln Glu Gln Gly Glu Met Val
        755                 760                 765             
Met Leu Tyr Asp Leu Phe Phe Ala Phe Leu Gln Thr Gly Asn Tyr Lys
    770                 775                 780                 
Glu Ala Lys Lys Ile Ile Glu Thr Pro Gly Ile Arg Ala Arg Ser Ala
785                 790                 795                 800 
Arg Leu Gln Trp Phe Cys Asp Arg Cys Val Ala Asn Asn Gln Val Glu
                805                 810                 815     
Thr Leu Glu Lys Leu Val Glu Leu Thr Gln Lys Leu Phe Glu Cys Asp
            820                 825                 830         
Arg Asp Gln Met Tyr Tyr Asn Leu Leu Lys Leu Tyr Lys Ile Asn Gly
        835                 840                 845             
Asp Trp Gln Arg Ala Asp Ala Val Trp Asn Lys Ile Gln Glu Glu Asn
    850                 855                 860                 
Val Ile Pro Arg Glu Lys Thr Leu Arg Leu Leu Ala Glu Ile Leu Arg
865                 870                 875                 880 
Glu Gly Asn Gln Glu Val Pro Phe Asp Val Pro Glu Leu Trp Tyr Glu
                885                 890                 895     
Asp Glu Lys His Ser Leu Asn Ser Ser Ser Ala Ser Thr Thr Glu Pro
            900                 905                 910         
Asp Phe Gln Lys Asp Ile Leu Ile Ala Cys Arg Leu Asn Gln Lys Lys
        915                 920                 925             
Gly Ala Tyr Asp Ile Phe Leu Asn Ala Lys Glu Gln Asn Ile Val Phe
    930                 935                 940                 
Asn Ala Glu Thr Tyr Ser Asn Leu Ile Lys Leu Leu Met Ser Glu Asp
945                 950                 955                 960 
Tyr Phe Thr Gln Ala Met Glu Val Lys Ala Phe Ala Glu Thr His Ile
                965                 970                 975     
Lys Gly Phe Thr Leu Asn Asp Ala Ala Asn Ser Arg Leu Ile Ile Thr
            980                 985                 990         
Gln Val Arg Arg Asp Tyr Leu Lys Glu Ala Val Thr Thr Leu Lys Thr
        995                 1000                1005            
Val Leu Asp Gln Gln Gln Thr Pro Ser Arg Leu Ala Val Thr Arg Val
    1010                1015                1020                
Ile Gln Ala Leu Ala Met Lys Gly Asp Val Glu Asn Ile Glu Val Val
1025                1030                1035                1040
Gln Lys Met Leu Asn Gly Leu Glu Asp Ser Ile Gly Leu Ser Lys Met
                1045                1050                1055    
Val Phe Ile Asn Asn Ile Ala Leu Ala Gln Ile Lys Asn Asn Asn Ile
            1060                1065                1070        
Asp Ala Ala Ile Glu Asn Ile Glu Asn Met Leu Thr Ser Glu Asn Lys
        1075                1080                1085            
Val Ile Glu Pro Gln Tyr Phe Gly Leu Ala Tyr Leu Phe Arg Lys Val
    1090                1095                1100                
Ile Glu Glu Gln Leu Glu Pro Ala Val Glu Lys Ile Ser Ile Met Ala
1105                1110                1115                1120
Glu Arg Leu Ala Asn Gln Phe Ala Ile Tyr Lys Pro Val Thr Asp Phe
                1125                1130                1135    
Phe Leu Gln Leu Val Asp Ala Gly Lys Val Asp Asp Ala Arg Ala Leu
            1140                1145                1150        
Leu Gln Arg Cys Gly Ala Ile Ala Glu Gln Thr Pro Ile Leu Leu Leu
        1155                1160                1165            
Phe Leu Leu Arg Asn Ser Arg Lys Gln Gly Lys Ala Ser Thr Val Lys
    1170                1175                1180                
Ser Val Leu Glu Leu Ile Pro Glu Leu Asn Glu Lys Glu Glu Ala Tyr
1185                1190                1195                1200
Asn Ser Leu Met Lys Ser Tyr Val Ser Glu Lys Asp Val Thr Ser Ala
                1205                1210                1215    
Lys Ala Leu Tyr Glu His Leu Thr Ala Lys Asn Thr Lys Leu Asp Asp
            1220                1225                1230        
Leu Phe Leu Lys Arg Tyr Ala Ser Leu Leu Lys Tyr Ala Gly Glu Pro
        1235                1240                1245            
Val Pro Phe Ile Glu Pro Pro Glu Ser Phe Glu Phe Tyr Ala Gln Gln
    1250                1255                1260                
Leu Arg Lys Leu Arg Glu Asn Ser Ser
1265                1270            


<210> 232
<211> 239
<212> PRT
<213> Homo sapiens

<400> 232
Lys Gly Leu Glu Gln Asn Ile Lys Asp Ser Phe Gln Lys Val Thr Leu
 1               5                  10                  15      
Ser Arg Tyr Gly Lys Tyr Gly His Lys Asn Leu Gln Leu Arg Lys Gly
            20                  25                  30          
Cys Lys Ser Val Asp Glu Cys Lys Glu His Gln Gly Gly Tyr Asn Gly
        35                  40                  45              
Leu Asn Gln Cys Leu Lys Ile Thr Thr Ser Lys Ile Phe Gln Cys Asn
    50                  55                  60                  
Lys Tyr Val Lys Val Met His Lys Phe Ser Asn Ser Asn Arg His Lys
65                  70                  75                  80  
Ile Arg His Thr Glu Asn Lys His Phe Arg Cys Lys Glu Cys Asp Lys
                85                  90                  95      
Ser Leu Cys Met Leu Ser Arg Leu Thr Gln His Lys Lys Ile His Thr
            100                 105                 110         
Arg Glu Asn Phe Tyr Lys Cys Glu Glu Cys Gly Lys Thr Phe Asn Trp
        115                 120                 125             
Ser Thr Asn Leu Ser Lys Pro Lys Lys Ile His Thr Gly Glu Lys Pro
    130                 135                 140                 
Tyr Lys Cys Glu Val Cys Gly Lys Ala Phe His Gln Ser Ser Ile Leu
145                 150                 155                 160 
Thr Lys His Lys Ile Ile Arg Thr Gly Glu Lys Pro Tyr Lys Cys Ala
                165                 170                 175     
His Cys Gly Lys Ala Phe Lys Gln Ser Ser His Leu Thr Arg His Lys
            180                 185                 190         
Ile Ile His Thr Glu Glu Lys Pro Tyr Lys Cys Glu Gln Cys Gly Lys
        195                 200                 205             
Val Phe Lys Gln Ser Pro Thr Leu Thr Lys His Gln Ile Ile Tyr Thr
    210                 215                 220                 
Gly Glu Glu Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn
225                 230                 235                 


<210> 233
<211> 772
<212> PRT
<213> Homo sapiens

<400> 233
Met Ala Glu Ala His Gln Ala Val Ala Phe Gln Phe Thr Val Thr Pro
 1               5                  10                  15      
Asp Gly Val Asp Phe Arg Leu Ser Arg Glu Ala Leu Lys His Val Tyr
            20                  25                  30          
Leu Ser Gly Ile Asn Ser Trp Lys Lys Arg Leu Ile Arg Ile Lys Asn
        35                  40                  45              
Gly Ile Leu Arg Gly Val Tyr Pro Gly Ser Pro Thr Ser Trp Leu Val
    50                  55                  60                  
Val Ile Met Ala Thr Val Gly Ser Ser Phe Cys Asn Val Asp Ile Ser
65                  70                  75                  80  
Leu Gly Leu Val Ser Cys Ile Gln Arg Cys Leu Pro Gln Gly Cys Gly
                85                  90                  95      
Pro Tyr Gln Thr Pro Gln Thr Arg Ala Leu Leu Ser Met Ala Ile Phe
            100                 105                 110         
Ser Thr Gly Val Trp Val Thr Gly Ile Phe Phe Phe Arg Gln Thr Leu
        115                 120                 125             
Lys Leu Leu Leu Cys Tyr His Gly Trp Met Phe Glu Met His Gly Lys
    130                 135                 140                 
Thr Ser Asn Leu Thr Arg Ile Trp Ala Met Cys Ile Arg Leu Leu Ser
145                 150                 155                 160 
Ser Arg His Pro Met Leu Tyr Ser Phe Gln Thr Ser Leu Pro Lys Leu
                165                 170                 175     
Pro Val Pro Arg Val Ser Ala Thr Ile Gln Arg Tyr Leu Glu Ser Val
            180                 185                 190         
Arg Pro Leu Leu Asp Asp Glu Glu Tyr Tyr Arg Met Glu Leu Leu Ala
        195                 200                 205             
Lys Glu Phe Gln Asp Lys Thr Ala Pro Arg Leu Gln Lys Tyr Leu Val
    210                 215                 220                 
Leu Lys Ser Trp Trp Ala Ser Asn Tyr Val Ser Asp Trp Trp Glu Glu
225                 230                 235                 240 
Tyr Ile Tyr Leu Arg Gly Arg Ser Pro Leu Met Val Asn Ser Asn Tyr
                245                 250                 255     
Tyr Val Met Asp Leu Val Leu Ile Lys Asn Thr Asp Val Gln Ala Ala
            260                 265                 270         
Arg Leu Gly Asn Ile Ile His Ala Met Ile Met Tyr Arg Arg Lys Leu
        275                 280                 285             
Asp Arg Glu Glu Ile Lys Pro Val Met Ala Leu Gly Ile Val Pro Met
    290                 295                 300                 
Cys Ser Tyr Gln Met Glu Arg Met Phe Asn Thr Thr Arg Ile Pro Gly
305                 310                 315                 320 
Lys Asp Thr Asp Val Leu Gln His Leu Ser Asp Ser Arg His Val Ala
                325                 330                 335     
Val Tyr His Lys Gly Arg Phe Phe Lys Leu Trp Leu Tyr Glu Gly Ala
            340                 345                 350         
Arg Leu Leu Lys Pro Gln Asp Leu Glu Met Gln Phe Gln Arg Ile Leu
        355                 360                 365             
Asp Asp Pro Ser Pro Pro Gln Pro Gly Glu Glu Lys Leu Ala Ala Leu
    370                 375                 380                 
Thr Ala Gly Gly Arg Val Glu Trp Ala Gln Ala Arg Gln Ala Phe Phe
385                 390                 395                 400 
Ser Ser Gly Lys Asn Lys Ala Ala Leu Glu Ala Ile Glu Arg Ala Ala
                405                 410                 415     
Phe Phe Val Ala Leu Asp Glu Glu Ser Tyr Ser Tyr Asp Pro Glu Asp
            420                 425                 430         
Glu Ala Ser Leu Ser Leu Tyr Gly Lys Ala Leu Leu His Gly Asn Cys
        435                 440                 445             
Tyr Asn Arg Trp Phe Asp Lys Ser Phe Thr Leu Ile Ser Phe Lys Asn
    450                 455                 460                 
Gly Gln Leu Gly Leu Asn Ala Glu His Ala Trp Ala Asp Ala Pro Ile
465                 470                 475                 480 
Ile Gly His Leu Trp Glu Phe Val Leu Gly Thr Asp Ser Phe His Leu
                485                 490                 495     
Gly Tyr Thr Glu Thr Gly His Cys Leu Gly Lys Pro Asn Pro Ala Leu
            500                 505                 510         
Ala Pro Pro Thr Arg Leu Gln Trp Asp Ile Pro Lys Gln Cys Gln Ala
        515                 520                 525             
Val Ile Lys Ser Ser Tyr Gln Val Ala Lys Ala Leu Ala Asp Asp Val
    530                 535                 540                 
Glu Leu Tyr Cys Phe Gln Phe Leu Pro Phe Gly Lys Gly Leu Ile Lys
545                 550                 555                 560 
Lys Cys Arg Thr Ser Pro Asp Ala Phe Val Gln Ile Ala Leu Gln Leu
                565                 570                 575     
Ala His Phe Arg Asp Arg Gly Lys Phe Cys Leu Thr Tyr Glu Ala Ser
            580                 585                 590         
Met Thr Arg Met Phe Arg Glu Gly Arg Thr Glu Thr Val Arg Ser Cys
        595                 600                 605             
Thr Ser Glu Ser Thr Ala Phe Val Gln Ala Met Met Glu Gly Ser His
    610                 615                 620                 
Thr Lys Ala Asp Leu Arg Asp Leu Phe Gln Lys Ala Ala Lys Lys His
625                 630                 635                 640 
Gln Asn Met Tyr Arg Leu Ala Met Thr Gly Ala Gly Ile Asp Arg His
                645                 650                 655     
Leu Phe Cys Leu Tyr Leu Val Ser Lys Tyr Leu Gly Val Ser Ser Pro
            660                 665                 670         
Phe Leu Ala Glu Val Leu Ser Glu Pro Trp Arg Leu Ser Thr Ser Gln
        675                 680                 685             
Ile Pro Gln Ser Gln Ile Arg Met Phe Asp Pro Glu Gln His Pro Asn
    690                 695                 700                 
His Leu Gly Ala Gly Gly Gly Phe Gly Pro Val Ala Asp Asp Gly Tyr
705                 710                 715                 720 
Gly Val Ser Tyr Met Ile Ala Gly Glu Asn Thr Ile Phe Phe His Ile
                725                 730                 735     
Ser Ser Lys Phe Ser Ser Ser Glu Thr Asn Ala Gln Arg Phe Gly Asn
            740                 745                 750         
His Ile Arg Lys Ala Leu Leu Asp Ile Ala Asp Leu Phe Gln Val Pro
        755                 760                 765             
Lys Ala Tyr Ser
    770         


<210> 234
<211> 1475
<212> PRT
<213> Homo sapiens

<400> 234
Met Ser Thr Asp Ser Asn Ser Leu Ala Arg Glu Phe Leu Thr Asp Val
 1               5                  10                  15      
Asn Arg Leu Cys Asn Ala Val Val Gln Arg Val Glu Ala Arg Glu Glu
            20                  25                  30          
Glu Glu Glu Glu Thr His Met Ala Thr Leu Gly Gln Tyr Leu Val His
        35                  40                  45              
Gly Arg Gly Phe Leu Leu Leu Thr Lys Leu Asn Ser Ile Ile Asp Gln
    50                  55                  60                  
Ala Leu Thr Cys Arg Glu Glu Leu Leu Thr Leu Leu Leu Ser Leu Leu
65                  70                  75                  80  
Pro Leu Val Trp Lys Ile Pro Val Gln Glu Glu Lys Ala Thr Asp Phe
                85                  90                  95      
Asn Leu Pro Leu Ser Ala Asp Ile Ile Leu Thr Lys Glu Lys Asn Ser
            100                 105                 110         
Ser Ser Gln Arg Ser Thr Gln Glu Lys Leu His Leu Glu Gly Ser Ala
        115                 120                 125             
Leu Ser Ser Gln Val Ser Ala Lys Val Asn Val Phe Arg Lys Ser Arg
    130                 135                 140                 
Arg Gln Arg Lys Ile Thr His Arg Tyr Ser Val Arg Asp Ala Arg Lys
145                 150                 155                 160 
Thr Gln Leu Ser Thr Ser Asp Ser Glu Ala Asn Ser Asp Glu Lys Gly
                165                 170                 175     
Ile Ala Met Asn Lys His Arg Arg Pro His Leu Leu His His Phe Leu
            180                 185                 190         
Thr Ser Phe Pro Lys Gln Asp His Pro Lys Ala Lys Leu Asp Arg Leu
        195                 200                 205             
Ala Thr Lys Glu Gln Thr Pro Pro Asp Ala Met Ala Leu Glu Asn Ser
    210                 215                 220                 
Arg Glu Ile Ile Pro Arg Gln Gly Ser Asn Thr Asp Ile Leu Ser Glu
225                 230                 235                 240 
Pro Ala Ala Leu Ser Val Ile Ser Asn Met Asn Asn Ser Pro Phe Asp
                245                 250                 255     
Leu Cys His Val Leu Leu Ser Leu Leu Glu Lys Val Cys Lys Phe Asp
            260                 265                 270         
Val Thr Leu Asn His Asn Ser Pro Leu Ala Ala Ser Val Val Pro Thr
        275                 280                 285             
Leu Thr Glu Phe Leu Ala Gly Phe Gly Asp Cys Cys Ser Leu Ser Asp
    290                 295                 300                 
Asn Leu Glu Ser Arg Val Val Ser Ala Gly Trp Thr Glu Glu Pro Val
305                 310                 315                 320 
Ala Leu Ile Gln Arg Met Leu Phe Arg Thr Val Leu His Leu Leu Ser
                325                 330                 335     
Val Asp Val Ser Thr Ala Glu Met Met Pro Glu Asn Leu Arg Lys Asn
            340                 345                 350         
Leu Thr Glu Leu Leu Arg Ala Ala Leu Lys Ile Arg Ile Cys Leu Glu
        355                 360                 365             
Lys Gln Pro Asp Pro Phe Ala Pro Arg Gln Lys Lys Thr Leu Gln Glu
    370                 375                 380                 
Val Gln Glu Asp Phe Val Phe Ser Lys Tyr Arg His Arg Ala Leu Leu
385                 390                 395                 400 
Leu Pro Glu Leu Leu Glu Gly Val Leu Gln Ile Leu Ile Cys Cys Leu
                405                 410                 415     
Gln Ser Ala Ala Ser Asn Pro Phe Tyr Phe Ser Gln Ala Met Asp Leu
            420                 425                 430         
Val Gln Glu Phe Ile Gln His His Gly Phe Asn Leu Phe Glu Thr Ala
        435                 440                 445             
Val Leu Gln Met Glu Trp Leu Val Leu Arg Asp Gly Val Pro Pro Glu
    450                 455                 460                 
Ala Ser Glu His Leu Lys Ala Leu Ile Asn Ser Val Met Lys Ile Met
465                 470                 475                 480 
Ser Thr Val Lys Lys Val Lys Ser Glu Gln Leu His His Ser Met Cys
                485                 490                 495     
Thr Arg Lys Arg His Arg Arg Cys Glu Tyr Ser His Phe Met His His
            500                 505                 510         
His Arg Asp Leu Ser Gly Leu Leu Val Ser Ala Phe Lys Asn Gln Val
        515                 520                 525             
Ser Lys Asn Pro Phe Glu Glu Thr Ala Asp Gly Asp Val Tyr Tyr Pro
    530                 535                 540                 
Glu Arg Cys Cys Cys Ile Ala Val Cys Ala His Gln Cys Leu Arg Leu
545                 550                 555                 560 
Leu Gln Gln Ala Ser Leu Ser Ser Thr Cys Val Gln Ile Leu Ser Gly
                565                 570                 575     
Val His Asn Ile Gly Ile Cys Cys Cys Met Asp Pro Lys Ser Val Ile
            580                 585                 590         
Ile Pro Leu Leu His Ala Phe Lys Leu Pro Ala Leu Lys Asn Phe Gln
        595                 600                 605             
Gln His Ile Leu Asn Ile Leu Asn Lys Leu Ile Leu Asp Gln Leu Gly
    610                 615                 620                 
Gly Ala Glu Ile Ser Pro Lys Ile Lys Lys Ala Ala Cys Asn Ile Cys
625                 630                 635                 640 
Thr Val Asp Ser Asp Gln Leu Ala Gln Leu Glu Glu Thr Leu Gln Gly
                645                 650                 655     
Asn Leu Cys Asp Ala Glu Leu Ser Ser Ser Leu Ser Ser Pro Ser Tyr
            660                 665                 670         
Arg Phe Gln Gly Ile Leu Pro Ser Ser Gly Ser Glu Asp Leu Leu Trp
        675                 680                 685             
Lys Trp Asp Ala Leu Lys Ala Tyr Gln Asn Phe Val Phe Gly Glu Asp
    690                 695                 700                 
Arg Leu His Ser Ile Gln Ile Ala Asn His Ile Cys Asn Leu Ile Gln
705                 710                 715                 720 
Lys Gly Asn Ile Val Val Gln Trp Lys Leu Tyr Asn Tyr Ile Phe Asn
                725                 730                 735     
Pro Val Leu Gln Arg Gly Val Glu Leu Ala His His Cys Gln His Leu
            740                 745                 750         
Ser Val Thr Ser Ala Gln Ser His Val Cys Ser His His Asn Gln Cys
        755                 760                 765             
Leu Pro Gln Asp Val Leu Gln Ile Tyr Val Lys Thr Leu Pro Ile Leu
    770                 775                 780                 
Leu Lys Ser Arg Val Ile Arg Asp Leu Phe Leu Ser Cys Asn Gly Val
785                 790                 795                 800 
Ser Gln Ile Ile Glu Leu Asn Cys Leu Asn Gly Ile Arg Ser His Ser
                805                 810                 815     
Leu Lys Ala Phe Glu Thr Leu Ile Ile Ser Leu Gly Glu Gln Gln Lys
            820                 825                 830         
Asp Ala Ser Val Pro Asp Ile Asp Gly Ile Asp Ile Glu Gln Lys Glu
        835                 840                 845             
Leu Ser Ser Val His Val Gly Thr Ser Phe His His Gln Gln Ala Tyr
    850                 855                 860                 
Ser Asp Ser Pro Gln Ser Leu Ser Lys Phe Tyr Ala Gly Leu Lys Glu
865                 870                 875                 880 
Ala Tyr Pro Lys Arg Arg Lys Thr Val Asn Gln Asp Val His Ile Asn
                885                 890                 895     
Thr Ile Asn Leu Phe Leu Cys Val Ala Phe Leu Cys Val Ser Lys Glu
            900                 905                 910         
Ala Glu Ser Asp Arg Glu Ser Ala Asn Asp Ser Glu Asp Thr Ser Gly
        915                 920                 925             
Tyr Asp Ser Thr Ala Ser Glu Pro Leu Ser His Met Leu Pro Cys Ile
    930                 935                 940                 
Ser Leu Glu Ser Leu Val Leu Pro Ser Pro Glu His Met His Gln Ala
945                 950                 955                 960 
Ala Asp Ile Trp Ser Met Cys Arg Trp Ile Tyr Met Leu Ser Ser Val
                965                 970                 975     
Phe Gln Lys Gln Phe Tyr Arg Leu Gly Gly Phe Arg Val Cys His Lys
            980                 985                 990         
Leu Ile Phe Met Ile Ile Gln Lys Leu Phe Arg Ser His Lys Glu Glu
        995                 1000                1005            
Gln Gly Lys Lys Glu Gly Asp Thr Ser Val Asn Glu Asn Gln Asp Leu
    1010                1015                1020                
Asn Arg Ile Ser Gln Pro Lys Arg Thr Met Lys Glu Asp Leu Leu Ser
1025                1030                1035                1040
Leu Ala Ile Lys Ser Asp Pro Ile Pro Ser Glu Leu Gly Ser Leu Lys
                1045                1050                1055    
Lys Ser Ala Asp Ser Leu Gly Lys Leu Glu Leu Gln His Ile Ser Ser
            1060                1065                1070        
Ile Asn Val Glu Glu Val Ser Ala Thr Glu Ala Ala Pro Glu Glu Ala
        1075                1080                1085            
Lys Leu Phe Thr Ser Gln Glu Ser Glu Thr Ser Leu Gln Ser Ile Arg
    1090                1095                1100                
Leu Leu Glu Ala Leu Leu Ala Ile Cys Leu His Gly Ala Arg Thr Ser
1105                1110                1115                1120
Gln Gln Lys Met Glu Leu Glu Leu Pro Asn Gln Asn Leu Ser Val Glu
                1125                1130                1135    
Ser Ile Leu Phe Glu Met Arg Asp His Leu Ser Gln Ser Lys Val Ile
            1140                1145                1150        
Glu Thr Gln Leu Ala Lys Pro Leu Phe Asp Ala Leu Leu Arg Val Ala
        1155                1160                1165            
Leu Gly Asn Tyr Ser Ala Asp Phe Glu His Asn Asp Ala Met Thr Glu
    1170                1175                1180                
Lys Ser His Gln Ser Ala Glu Glu Leu Ser Ser Gln Pro Gly Asp Phe
1185                1190                1195                1200
Ser Glu Glu Ala Glu Asp Ser Gln Cys Cys Ser Phe Lys Leu Leu Val
                1205                1210                1215    
Glu Glu Glu Gly Tyr Glu Ala Asp Ser Glu Ser Asn Pro Glu Asp Gly
            1220                1225                1230        
Glu Thr Gln Asp Asp Gly Val Asp Leu Lys Ser Glu Thr Glu Gly Phe
        1235                1240                1245            
Ser Ala Ser Ser Ser Pro Asn Asp Leu Leu Glu Asn Leu Thr Gln Gly
    1250                1255                1260                
Glu Ile Ile Tyr Pro Glu Ile Cys Met Leu Glu Leu Asn Leu Leu Ser
1265                1270                1275                1280
Ala Ser Lys Ala Lys Leu Asp Val Leu Ala His Val Phe Glu Ser Phe
                1285                1290                1295    
Leu Lys Ile Ile Arg Gln Lys Glu Lys Asn Val Phe Leu Leu Met Gln
            1300                1305                1310        
Gln Gly Thr Val Lys Asn Leu Leu Gly Gly Phe Leu Ser Ile Leu Thr
        1315                1320                1325            
Gln Asp Asp Ser Asp Phe Gln Ala Cys Gln Arg Val Leu Val Asp Leu
    1330                1335                1340                
Leu Val Ser Leu Met Ser Ser Arg Thr Cys Ser Glu Glu Leu Thr Leu
1345                1350                1355                1360
Leu Leu Arg Ile Phe Leu Glu Lys Ser Pro Cys Thr Lys Ile Leu Leu
                1365                1370                1375    
Leu Gly Ile Leu Lys Ile Ile Glu Ser Asp Thr Thr Met Ser Pro Ser
            1380                1385                1390        
Gln Tyr Leu Thr Phe Pro Leu Leu His Ala Pro Asn Leu Ser Asn Gly
        1395                1400                1405            
Val Ser Ser Gln Lys Tyr Pro Gly Ile Leu Asn Ser Lys Ala Met Gly
    1410                1415                1420                
Leu Leu Arg Arg Ala Arg Val Ser Arg Ser Lys Lys Glu Ala Asp Arg
1425                1430                1435                1440
Glu Ser Phe Pro His Arg Leu Leu Ser Ser Trp Asp Ile Ala Pro Val
                1445                1450                1455    
His Leu Pro Leu Val Gly Gln Asn Cys Trp Pro His Leu Ser Glu Gly
            1460                1465                1470        
Phe Ser Val
        1475


<210> 235
<211> 1561
<212> PRT
<213> Homo sapiens

<400> 235
Ile Glu Glu Gly Ser Lys Ala Ala Ala Val Asp Lys Leu Leu Ala Gly
 1               5                  10                  15      
Asp Glu Ile Val Gly Ile Asn Asp Ile Gly Leu Ser Gly Phe Arg Gln
            20                  25                  30          
Glu Ala Ile Cys Leu Val Lys Gly Ser His Lys Thr Leu Lys Leu Val
        35                  40                  45              
Val Lys Arg Arg Ser Glu Leu Gly Trp Arg Pro His Ser Trp His Ala
    50                  55                  60                  
Thr Lys Phe Ser Asp Ser His Pro Glu Leu Ala Ala Ser Pro Phe Thr
65                  70                  75                  80  
Ser Thr Ser Gly Cys Pro Ser Trp Ser Gly Arg His His Ala Ser Ser
                85                  90                  95      
Ser Ser His Asp Leu Ser Ser Ser Trp Glu Gln Thr Asn Leu Gln Arg
            100                 105                 110         
Thr Leu Asp His Phe Ser Ser Leu Gly Ser Val Asp Ser Leu Asp His
        115                 120                 125             
Pro Ser Ser Arg Leu Ser Val Ala Lys Ser Asn Ser Ser Ile Asp His
    130                 135                 140                 
Leu Gly Ser His Ser Lys Arg Asp Ser Ala Tyr Gly Ser Phe Ser Thr
145                 150                 155                 160 
Ser Ser Ser Thr Pro Asp His Thr Leu Ser Lys Ala Asp Thr Ser Ser
                165                 170                 175     
Ala Glu Asn Ile Leu Tyr Thr Val Gly Leu Trp Glu Ala Pro Arg Gln
            180                 185                 190         
Gly Gly Arg Gln Ala Gln Ala Ala Gly Asp Pro Gln Gly Ser Glu Glu
        195                 200                 205             
Lys Leu Ser Cys Phe Pro Pro Arg Val Pro Gly Asp Ser Gly Lys Gly
    210                 215                 220                 
Pro Arg Pro Glu Tyr Asn Ala Glu Pro Lys Leu Ala Ala Pro Gly Arg
225                 230                 235                 240 
Ser Asn Phe Gly Pro Val Trp Tyr Val Pro Asp Lys Lys Lys Ala Pro
                245                 250                 255     
Ser Ser Pro Pro Pro Pro Pro Pro Pro Leu Arg Ser Asp Ser Phe Ala
            260                 265                 270         
Ala Thr Lys Ser His Glu Lys Ala Gln Gly Pro Val Phe Ser Glu Ala
        275                 280                 285             
Ala Ala Ala Gln His Phe Thr Ala Leu Ala Gln Ala Gln Pro Arg Gly
    290                 295                 300                 
Asp Arg Arg Pro Glu Leu Thr Asp Arg Pro Trp Arg Ser Ala His Pro
305                 310                 315                 320 
Gly Ser Leu Gly Lys Gly Ser Gly Gly Pro Gly Cys Pro Gln Glu Ala
                325                 330                 335     
His Ala Asp Gly Ser Trp Pro Pro Ser Lys Asp Gly Ala Ser Ser Arg
            340                 345                 350         
Leu Gln Ala Ser Leu Ser Ser Ser Asp Val Arg Phe Pro Gln Ser Pro
        355                 360                 365             
His Ser Gly Arg His Pro Pro Leu Tyr Ser Asp His Ser Pro Leu Cys
    370                 375                 380                 
Ala Asp Ser Leu Gly Gln Glu Pro Gly Ala Ala Ser Phe Gln Asn Asp
385                 390                 395                 400 
Ser Pro Pro Gln Val Arg Gly Leu Ser Ser Cys Asp Gln Lys Leu Gly
                405                 410                 415     
Ser Gly Trp Gln Gly Pro Arg Pro Cys Val Gln Gly Asp Leu Gln Ala
            420                 425                 430         
Ala Gln Leu Trp Ala Gly Cys Trp Pro Ser Asp Thr Ala Leu Gly Ala
        435                 440                 445             
Leu Glu Ser Leu Pro Pro Pro Thr Val Gly Gln Ser Pro Arg His His
    450                 455                 460                 
Leu Pro Gln Pro Glu Gly Pro Pro Asp Ala Arg Glu Thr Gly Arg Cys
465                 470                 475                 480 
Tyr Pro Leu Asp Lys Gly Ala Glu Gly Cys Ser Ala Gly Ala Gln Glu
                485                 490                 495     
Pro Pro Arg Ala Ser Arg Ala Glu Lys Ala Ser Gln Arg Leu Ala Ala
            500                 505                 510         
Ser Ile Thr Trp Ala Asp Gly Glu Ser Ser Arg Ile Cys Pro Gln Glu
        515                 520                 525             
Thr Pro Leu Leu His Ser Leu Thr Gln Glu Gly Lys Arg Arg Pro Glu
    530                 535                 540                 
Ser Ser Pro Glu Asp Ser Ala Thr Arg Pro Pro Pro Phe Asp Ala His
545                 550                 555                 560 
Val Gly Lys Pro Thr Arg Arg Ser Asp Arg Phe Ala Thr Thr Leu Arg
                565                 570                 575     
Asn Glu Ile Gln Met His Arg Ala Lys Leu Gln Lys Ser Arg Ser Thr
            580                 585                 590         
Val Ala Leu Thr Ala Ala Gly Glu Ala Glu Asp Gly Thr Gly Arg Trp
        595                 600                 605             
Arg Ala Gly Leu Gly Gly Gly Thr Gln Glu Gly Pro Leu Ala Gly Thr
    610                 615                 620                 
Tyr Lys Asp His Leu Lys Glu Ala Gln Ala Arg Val Leu Arg Ala Thr
625                 630                 635                 640 
Ser Phe Lys Arg Arg Asp Leu Asp Pro Asn Pro Gly Asp Leu Tyr Pro
                645                 650                 655     
Glu Ser Leu Glu His Arg Met Gly Asp Pro Asp Thr Val Pro His Phe
            660                 665                 670         
Trp Glu Ala Gly Leu Ala Gln Pro Pro Ser Ser Thr Ser Gly Gly Pro
        675                 680                 685             
His Pro Pro Arg Ile Gly Gly Arg Arg Arg Phe Thr Ala Glu Gln Lys
    690                 695                 700                 
Leu Lys Ser Tyr Ser Glu Pro Glu Lys Met Asn Glu Val Gly Leu Thr
705                 710                 715                 720 
Arg Gly Tyr Ser Pro His Gln His Pro Arg Thr Ser Glu Asp Thr Val
                725                 730                 735     
Gly Thr Phe Ala Asp Arg Trp Lys Phe Phe Glu Glu Thr Ser Lys Pro
            740                 745                 750         
Val Pro Gln Arg Pro Ala Gln Lys Gln Ala Leu His Gly Ile Pro Arg
        755                 760                 765             
Asp Lys Pro Glu Arg Pro Arg Thr Ala Gly Arg Thr Cys Glu Gly Thr
    770                 775                 780                 
Glu Pro Trp Ser Arg Thr Thr Ser Leu Gly Asp Ser Leu Asn Ala His
785                 790                 795                 800 
Ser Ala Ala Glu Lys Ala Gly Thr Ser Asp Leu Pro Arg Arg Leu Gly
                805                 810                 815     
Thr Phe Ala Glu Tyr Gln Ala Ser Trp Lys Glu Gln Arg Lys Pro Leu
            820                 825                 830         
Glu Ala Arg Ser Ser Gly Arg Cys His Ser Ala Asp Asp Ile Leu Asp
        835                 840                 845             
Val Ser Leu Asp Pro Gln Glu Arg Pro Gln His Val His Gly Arg Ser
    850                 855                 860                 
Arg Ser Ser Pro Ser Thr Asp His Tyr Lys Gln Glu Ala Ser Val Glu
865                 870                 875                 880 
Leu Arg Arg Gln Ala Gly Asp Pro Gly Glu Pro Arg Glu Glu Leu Pro
                885                 890                 895     
Ser Ala Val Arg Ala Glu Glu Gly Gln Ser Thr Pro Arg Gln Ala Asp
            900                 905                 910         
Ala Gln Cys Arg Glu Gly Ser Pro Gly Ser Gln Gln His Pro Pro Ser
        915                 920                 925             
Gln Lys Ala Pro Asn Pro Pro Thr Phe Ser Glu Leu Ser His Cys Arg
    930                 935                 940                 
Gly Ala Pro Glu Leu Pro Arg Glu Gly Arg Gly Arg Ala Gly Thr Leu
945                 950                 955                 960 
Pro Arg Asp Tyr Arg Tyr Ser Glu Glu Ser Thr Pro Ala Asp Leu Gly
                965                 970                 975     
Pro Arg Ala Gln Ser Pro Gly Ser Pro Leu His Ala Arg Gly Gln Asp
            980                 985                 990         
Ser Trp Pro Val Ser Ser Ala Leu Leu Ser Lys Arg Pro Ala Pro Gln
        995                 1000                1005            
Arg Pro Pro Pro Pro Lys Arg Glu Pro Arg Arg Tyr Arg Ala Thr Asp
    1010                1015                1020                
Gly Ala Pro Ala Asp Ala Pro Val Gly Val Leu Gly Arg Pro Phe Pro
1025                1030                1035                1040
Thr Pro Ser Pro Ala Ser Leu Asp Val Tyr Val Ala Arg Leu Ser Leu
                1045                1050                1055    
Ser His Ser Pro Ser Val Phe Ser Ser Ala Gln Pro Gln Asp Thr Pro
            1060                1065                1070        
Lys Ala Thr Val Cys Glu Arg Gly Ser Gln His Val Ser Gly Asp Ala
        1075                1080                1085            
Ser Arg Pro Leu Pro Glu Ala Leu Leu Pro Pro Lys Gln Gln His Leu
    1090                1095                1100                
Arg Leu Gln Thr Ala Thr Met Glu Thr Ser Arg Ser Pro Ser Pro Gln
1105                1110                1115                1120
Phe Ala Pro Gln Lys Leu Thr Asp Lys Pro Pro Leu Leu Ile Gln Asp
                1125                1130                1135    
Glu Asp Ser Thr Arg Ile Glu Arg Val Met Asp Asn Asn Thr Thr Val
            1140                1145                1150        
Lys Met Val Pro Ile Lys Ile Val His Ser Glu Ser Gln Pro Glu Lys
        1155                1160                1165            
Glu Ser Arg Gln Ser Leu Ala Cys Pro Ala Glu Pro Pro Ala Leu Pro
    1170                1175                1180                
His Gly Leu Glu Lys Asp Gln Ile Lys Thr Leu Ser Thr Ser Glu Gln
1185                1190                1195                1200
Phe Tyr Ser Arg Phe Cys Leu Tyr Thr Arg Gln Gly Ala Glu Pro Glu
                1205                1210                1215    
Ala Pro His Arg Ala Gln Pro Ala Glu Pro Gln Pro Leu Gly Thr Gln
            1220                1225                1230        
Val Pro Pro Glu Lys Asp Arg Cys Thr Ser Pro Pro Gly Leu Ser Tyr
        1235                1240                1245            
Met Lys Ala Lys Glu Lys Thr Val Glu Asp Leu Lys Ser Glu Glu Leu
    1250                1255                1260                
Ala Arg Glu Ile Val Gly Lys Asp Lys Ser Leu Ala Asp Ile Leu Asp
1265                1270                1275                1280
Pro Ser Val Lys Ile Lys Thr Thr Met Asp Leu Met Glu Gly Ile Phe
                1285                1290                1295    
Pro Lys Asp Glu His Leu Leu Glu Glu Ala Gln Gln Arg Arg Lys Leu
            1300                1305                1310        
Leu Pro Lys Ile Pro Ser Pro Arg Ser Thr Glu Glu Arg Lys Glu Glu
        1315                1320                1325            
Pro Ser Val Pro Ala Ala Val Ser Leu Ala Thr Asn Ser Thr Tyr Tyr
    1330                1335                1340                
Ser Thr Ser Ala Pro Lys Ala Glu Leu Leu Ile Lys Met Lys Asp Leu
1345                1350                1355                1360
Gln Glu Gln Gln Glu His Glu Glu Asp Ser Gly Ser Asp Leu Asp His
                1365                1370                1375    
Asp Leu Ser Val Lys Lys Gln Glu Leu Ile Glu Ser Ile Ser Arg Lys
            1380                1385                1390        
Leu Gln Val Leu Arg Glu Ala Arg Glu Ser Leu Leu Glu Asp Val Gln
        1395                1400                1405            
Ala Asn Thr Val Leu Gly Ala Glu Val Glu Ala Ile Val Lys Gly Val
    1410                1415                1420                
Cys Lys Pro Ser Glu Phe Asp Lys Phe Arg Met Phe Ile Gly Asp Leu
1425                1430                1435                1440
Asp Lys Val Val Asn Leu Leu Leu Ser Leu Ser Gly Arg Leu Ala Arg
                1445                1450                1455    
Val Glu Asn Ala Leu Asn Asn Leu Asp Asp Gly Ala Ser Pro Gly Asp
            1460                1465                1470        
Arg Gln Ser Leu Leu Glu Lys Gln Arg Val Leu Ile Gln Gln His Glu
        1475                1480                1485            
Asp Ala Lys Glu Leu Lys Glu Asn Leu Asp Arg Arg Glu Arg Ile Val
    1490                1495                1500                
Phe Asp Ile Leu Ala Asn Tyr Leu Ser Glu Glu Ser Leu Ala Asp Tyr
1505                1510                1515                1520
Glu His Phe Val Lys Met Lys Ser Ala Leu Ile Ile Glu Gln Arg Glu
                1525                1530                1535    
Leu Glu Asp Lys Ile His Leu Gly Glu Glu Gln Leu Lys Cys Leu Leu
            1540                1545                1550        
Asp Ser Leu Gln Pro Glu Arg Gly Lys
        1555                1560    


<210> 236
<211> 461
<212> PRT
<213> Homo sapiens

<400> 236
Met Gly Ser Pro Ala His Arg Pro Ala Leu Leu Leu Leu Leu Pro Pro
 1               5                  10                  15      
Leu Leu Leu Leu Leu Leu Arg Val Pro Pro Ser Arg Ser Phe Pro Gly
            20                  25                  30          
Ser Gly Asp Ser Pro Leu Glu Asp Asp Glu Val Gly Tyr Ser His Pro
        35                  40                  45              
Arg Tyr Lys Asp Thr Pro Trp Cys Ser Pro Ile Lys Val Lys Tyr Gly
    50                  55                  60                  
Asp Val Tyr Cys Arg Ala Pro Gln Gly Gly Tyr Tyr Lys Thr Ala Leu
65                  70                  75                  80  
Gly Thr Arg Cys Asp Ile Arg Cys Gln Lys Gly Tyr Glu Leu His Gly
                85                  90                  95      
Ser Ser Leu Leu Ile Cys Gln Ser Asn Lys Arg Trp Ser Asp Lys Val
            100                 105                 110         
Ile Cys Lys Gln Lys Arg Cys Pro Thr Leu Ala Met Pro Ala Asn Gly
        115                 120                 125             
Gly Phe Lys Cys Val Asp Gly Ala Tyr Phe Asn Ser Arg Cys Glu Tyr
    130                 135                 140                 
Tyr Cys Ser Pro Gly Tyr Thr Leu Lys Gly Glu Arg Thr Val Thr Cys
145                 150                 155                 160 
Met Asp Asn Lys Ala Trp Ser Gly Ala Ser Leu Leu Cys Gly Tyr Gly
                165                 170                 175     
Pro Pro Arg Ile Lys Cys Pro Ser Val Lys Glu Arg Ile Ala Glu Pro
            180                 185                 190         
Asn Lys Leu Thr Val Arg Val Trp Glu Thr Pro Glu Gly Arg Asp Thr
        195                 200                 205             
Ala Asp Gly Ile Leu Thr Asp Val Ile Leu Lys Gly Leu Pro Pro Gly
    210                 215                 220                 
Ser Asn Phe Pro Glu Gly Asp His Lys Ile Gln Tyr Thr Val Tyr Asp
225                 230                 235                 240 
Arg Ala Glu Asn Lys Gly Thr Cys Lys Phe Arg Val Lys Val Arg Val
                245                 250                 255     
Lys Arg Cys Gly Lys Leu Asn Ala Pro Glu Asn Gly Tyr Met Lys Cys
            260                 265                 270         
Ser Ser Asp Gly Asp Asn Tyr Gly Ala Thr Cys Glu Phe Ser Cys Ile
        275                 280                 285             
Gly Gly Tyr Glu Leu Gln Gly Ser Pro Ala Arg Val Cys Gln Ser Asn
    290                 295                 300                 
Leu Ala Trp Ser Gly Thr Glu Pro Thr Cys Ala Ala Met Asn Val Asn
305                 310                 315                 320 
Val Gly Val Arg Thr Ala Ala Ala Leu Leu Asp Gln Phe Tyr Glu Lys
                325                 330                 335     
Arg Arg Leu Leu Ile Val Ser Thr Pro Thr Ala Arg Asn Leu Leu Tyr
            340                 345                 350         
Arg Leu Gln Leu Gly Met Leu Gln Gln Ala Gln Cys Gly Leu Asp Leu
        355                 360                 365             
Arg His Ile Thr Val Val Glu Leu Val Gly Val Phe Pro Thr Leu Ile
    370                 375                 380                 
Gly Arg Ile Gly Ala Lys Ile Met Pro Pro Ala Leu Ala Leu Gln Leu
385                 390                 395                 400 
Arg Leu Leu Leu Arg Ile Pro Leu Tyr Ser Phe Ser Met Val Leu Val
                405                 410                 415     
Asp Lys His Gly Met Asp Lys Glu Arg Tyr Val Ser Leu Val Met Pro
            420                 425                 430         
Val Ala Leu Phe Asn Leu Ile Asp Thr Phe Pro Leu Arg Lys Glu Glu
        435                 440                 445             
Met Val Leu Gln Ala Glu Met Ser Gln Thr Cys Asn Thr
    450                 455                 460     


<210> 237
<211> 1411
<212> PRT
<213> Homo sapiens

<400> 237
Met Ala Glu Ala Arg Lys Arg Arg Glu Leu Leu Pro Leu Ile Tyr His
 1               5                  10                  15      
His Leu Leu Arg Ala Gly Tyr Val Arg Ala Ala Arg Glu Val Lys Glu
            20                  25                  30          
Gln Ser Gly Gln Lys Cys Phe Leu Ala Gln Pro Val Thr Leu Leu Asp
        35                  40                  45              
Ile Tyr Thr His Trp Gln Gln Thr Ser Glu Leu Gly Arg Lys Arg Lys
    50                  55                  60                  
Ala Glu Glu Asp Ala Ala Leu Gln Ala Lys Lys Thr Arg Val Ser Asp
65                  70                  75                  80  
Pro Ile Ser Thr Ser Glu Ser Ser Glu Glu Glu Glu Glu Ala Glu Ala
                85                  90                  95      
Glu Thr Ala Lys Ala Thr Pro Arg Leu Ala Ser Thr Asn Ser Ser Val
            100                 105                 110         
Leu Gly Ala Asp Leu Pro Ser Ser Met Lys Glu Lys Ala Lys Ala Glu
        115                 120                 125             
Thr Glu Lys Ala Gly Lys Thr Gly Asn Ser Met Pro His Pro Ala Thr
    130                 135                 140                 
Gly Lys Thr Val Ala Asn Leu Leu Ser Gly Lys Ser Pro Arg Lys Ser
145                 150                 155                 160 
Ala Glu Pro Ser Ala Asn Thr Thr Leu Val Ser Glu Thr Glu Glu Glu
                165                 170                 175     
Gly Ser Val Pro Ala Phe Gly Ala Ala Ala Lys Pro Gly Met Val Ser
            180                 185                 190         
Ala Gly Gln Ala Asp Ser Ser Ser Glu Asp Thr Ser Ser Ser Ser Asp
        195                 200                 205             
Glu Thr Asp Val Glu Val Lys Ala Ser Glu Lys Ile Leu Gln Val Arg
    210                 215                 220                 
Ala Ala Ser Ala Pro Ala Lys Gly Thr Pro Gly Lys Gly Ala Thr Pro
225                 230                 235                 240 
Ala Pro Pro Gly Lys Ala Gly Ala Val Ala Ser Gln Thr Lys Ala Gly
                245                 250                 255     
Lys Pro Glu Glu Asp Ser Glu Ser Ser Ser Glu Glu Ser Ser Asp Ser
            260                 265                 270         
Glu Glu Glu Thr Pro Ala Ala Lys Ala Leu Leu Gln Ala Lys Ala Ser
        275                 280                 285             
Gly Lys Thr Ser Gln Val Gly Ala Ala Ser Ala Pro Ala Lys Glu Ser
    290                 295                 300                 
Pro Arg Lys Gly Ala Ala Pro Ala Pro Pro Gly Lys Thr Gly Pro Ala
305                 310                 315                 320 
Val Ala Lys Ala Gln Ala Gly Lys Arg Glu Glu Asp Ser Gln Ser Ser
                325                 330                 335     
Ser Glu Glu Ser Asp Ser Glu Glu Glu Ala Pro Ala Gln Ala Lys Pro
            340                 345                 350         
Ser Gly Lys Ala Pro Gln Val Arg Ala Ala Ser Ala Pro Ala Lys Glu
        355                 360                 365             
Ser Pro Arg Lys Gly Ala Ala Pro Ala Pro Pro Arg Lys Thr Gly Pro
    370                 375                 380                 
Ala Ala Ala Gln Val Gln Val Gly Lys Gln Glu Glu Asp Ser Arg Ser
385                 390                 395                 400 
Ser Ser Glu Glu Ser Asp Ser Asp Arg Glu Ala Leu Ala Ala Met Asn
                405                 410                 415     
Ala Ala Gln Val Lys Pro Leu Gly Lys Ser Pro Gln Val Lys Pro Ala
            420                 425                 430         
Ser Thr Met Gly Met Gly Pro Leu Gly Lys Gly Ala Gly Pro Val Pro
        435                 440                 445             
Pro Gly Lys Val Gly Pro Ala Thr Pro Ser Ala Gln Val Gly Lys Trp
    450                 455                 460                 
Glu Glu Asp Ser Glu Ser Ser Ser Glu Glu Ser Ser Asp Ser Ser Asp
465                 470                 475                 480 
Gly Glu Val Pro Thr Ala Val Ala Pro Ala Gln Glu Lys Ser Leu Gly
                485                 490                 495     
Asn Ile Leu Gln Ala Lys Pro Thr Ser Ser Pro Ala Lys Gly Pro Pro
            500                 505                 510         
Gln Lys Ala Gly Pro Val Ala Val Gln Val Lys Ala Glu Lys Pro Met
        515                 520                 525             
Asp Asn Ser Glu Ser Ser Glu Glu Ser Ser Asp Ser Ala Asp Ser Glu
    530                 535                 540                 
Glu Ala Pro Ala Ala Met Thr Ala Ala Gln Ala Lys Pro Ala Leu Lys
545                 550                 555                 560 
Ile Pro Gln Thr Lys Ala Cys Pro Lys Lys Thr Asn Thr Thr Ala Ser
                565                 570                 575     
Ala Lys Val Ala Pro Val Arg Val Gly Thr Gln Pro Pro Arg Lys Ala
            580                 585                 590         
Gly Thr Ala Thr Ser Pro Ala Gly Ser Ser Pro Ala Val Ala Gly Gly
        595                 600                 605             
Thr Gln Arg Pro Ala Glu Asp Ser Ser Ser Ser Glu Glu Ser Asp Ser
    610                 615                 620                 
Glu Glu Glu Lys Thr Gly Leu Ala Val Thr Val Gly Gln Ala Lys Ser
625                 630                 635                 640 
Val Gly Lys Gly Leu Gln Val Lys Ala Ala Ser Val Pro Val Lys Gly
                645                 650                 655     
Ser Leu Gly Gln Gly Thr Ala Pro Val Leu Pro Gly Lys Thr Gly Pro
            660                 665                 670         
Thr Val Thr Gln Val Lys Ala Glu Lys Gln Glu Asp Ser Glu Ser Ser
        675                 680                 685             
Glu Glu Glu Ser Asp Ser Glu Glu Ala Ala Ala Ser Pro Ala Gln Val
    690                 695                 700                 
Lys Thr Ser Val Lys Lys Thr Gln Ala Lys Ala Asn Pro Ala Ala Ala
705                 710                 715                 720 
Arg Ala Pro Ser Ala Lys Gly Thr Ile Ser Ala Pro Gly Lys Val Val
                725                 730                 735     
Thr Ala Ala Ala Gln Ala Lys Gln Arg Ser Pro Ser Lys Val Lys Pro
            740                 745                 750         
Pro Val Arg Asn Pro Gln Asn Ser Thr Val Leu Ala Arg Gly Pro Ala
        755                 760                 765             
Ser Val Pro Ser Val Gly Lys Ala Val Ala Thr Ala Ala Gln Ala Gln
    770                 775                 780                 
Thr Gly Pro Glu Glu Asp Ser Gly Ser Ser Glu Glu Glu Ser Asp Ser
785                 790                 795                 800 
Glu Glu Glu Ala Glu Thr Leu Ala Gln Ala Lys Pro Ser Gly Lys Thr
                805                 810                 815     
His Gln Ile Arg Ala Ala Leu Ala Pro Ala Lys Glu Ser Pro Arg Lys
            820                 825                 830         
Gly Ala Ala Pro Thr Pro Pro Gly Lys Thr Gly Pro Ser Ala Ala Gln
        835                 840                 845             
Ala Gly Lys Gln Asp Asp Ser Gly Ser Ser Ser Glu Glu Ser Asp Ser
    850                 855                 860                 
Asp Gly Glu Ala Pro Ala Ala Val Thr Ser Ala Gln Val Ile Lys Pro
865                 870                 875                 880 
Pro Leu Ile Phe Val Asp Pro Asn Arg Ser Pro Ala Gly Pro Ala Ala
                885                 890                 895     
Thr Pro Ala Gln Ala Gln Ala Ala Ser Thr Pro Arg Lys Ala Arg Ala
            900                 905                 910         
Ser Glu Ser Thr Ala Arg Ser Ser Ser Ser Glu Ser Glu Asp Glu Asp
        915                 920                 925             
Val Ile Pro Ala Thr Gln Cys Leu Thr Pro Gly Ile Arg Thr Asn Val
    930                 935                 940                 
Val Thr Met Pro Thr Ala His Pro Arg Ile Ala Pro Lys Ala Ser Met
945                 950                 955                 960 
Ala Gly Ala Ser Ser Ser Lys Glu Ser Ser Arg Ile Ser Asp Gly Lys
                965                 970                 975     
Lys Gln Glu Gly Pro Ala Thr Gln Val Ser Lys Lys Asn Pro Ala Ser
            980                 985                 990         
Leu Pro Leu Thr Gln Ala Ala Leu Lys Val Leu Ala Gln Lys Ala Ser
        995                 1000                1005            
Glu Ala Gln Pro Pro Val Ala Arg Thr Gln Pro Ser Ser Gly Val Asp
    1010                1015                1020                
Ser Ala Val Gly Thr Leu Pro Ala Thr Ser Pro Gln Ser Thr Ser Val
1025                1030                1035                1040
Gln Ala Lys Gly Thr Asn Lys Leu Arg Lys Pro Lys Leu Pro Glu Val
                1045                1050                1055    
Gln Gln Ala Thr Lys Ala Pro Glu Ser Ser Asp Asp Ser Glu Asp Ser
            1060                1065                1070        
Ser Asp Ser Ser Ser Gly Ser Glu Glu Asp Gly Glu Gly Pro Gln Gly
        1075                1080                1085            
Ala Lys Ser Ala His Thr Leu Gly Pro Thr Pro Ser Arg Thr Glu Thr
    1090                1095                1100                
Leu Val Glu Glu Thr Ala Ala Glu Ser Ser Glu Asp Asp Val Val Ala
1105                1110                1115                1120
Pro Ser Gln Ser Leu Leu Ser Gly Tyr Met Thr Pro Gly Leu Thr Pro
                1125                1130                1135    
Ala Asn Ser Gln Ala Ser Lys Ala Thr Pro Lys Leu Asp Ser Ser Pro
            1140                1145                1150        
Ser Val Ser Ser Thr Leu Ala Ala Lys Asp Asp Pro Asp Gly Lys Gln
        1155                1160                1165            
Glu Ala Lys Pro Gln Gln Ala Ala Gly Met Leu Ser Pro Lys Thr Gly
    1170                1175                1180                
Gly Lys Glu Ala Ala Ser Gly Thr Thr Pro Gln Lys Ser Arg Lys Pro
1185                1190                1195                1200
Lys Lys Gly Ala Gly Asn Pro Gln Ala Ser Thr Leu Ala Leu Gln Ser
                1205                1210                1215    
Asn Ile Thr Gln Cys Leu Leu Gly Gln Pro Trp Pro Leu Asn Glu Ala
            1220                1225                1230        
Gln Val Gln Ala Ser Val Val Lys Val Leu Thr Glu Leu Leu Glu Gln
        1235                1240                1245            
Glu Arg Lys Lys Val Val Asp Thr Thr Lys Glu Ser Ser Arg Lys Gly
    1250                1255                1260                
Trp Glu Ser Arg Lys Arg Lys Leu Ser Gly Asp Gln Pro Ala Ala Arg
1265                1270                1275                1280
Thr Pro Arg Ser Lys Lys Lys Lys Lys Leu Gly Ala Gly Glu Gly Gly
                1285                1290                1295    
Glu Ala Ser Val Ser Pro Glu Lys Thr Ser Thr Thr Ser Lys Gly Gln
            1300                1305                1310        
Ala Lys Arg Asp Lys Ala Ser Gly Asp Val Lys Glu Lys Lys Gly Lys
        1315                1320                1325            
Gly Ser Leu Gly Ser Gln Gly Ala Lys Asp Glu Pro Glu Glu Glu Leu
    1330                1335                1340                
Gln Lys Gly Met Gly Thr Val Glu Gly Gly Asp Gln Ser Asn Pro Lys
1345                1350                1355                1360
Ser Lys Lys Glu Lys Lys Lys Ser Asp Lys Arg Lys Lys Asp Lys Glu
                1365                1370                1375    
Lys Lys Glu Lys Lys Lys Lys Ala Lys Lys Ala Ser Thr Lys Asp Ser
            1380                1385                1390        
Glu Ser Pro Ser Gln Lys Lys Lys Lys Lys Lys Lys Lys Thr Ala Glu
        1395                1400                1405            
Gln Thr Val
    1410    


<210> 238
<211> 2477
<212> PRT
<213> Homo sapiens

<400> 238
Met Asp Pro Ser Gly Val Lys Val Leu Glu Thr Ala Glu Asp Ile Gln
 1               5                  10                  15      
Glu Arg Arg Gln Gln Val Leu Asp Arg Tyr His Arg Phe Lys Glu Leu
            20                  25                  30          
Ser Thr Leu Arg Arg Gln Lys Leu Glu Asp Ser Tyr Arg Phe Gln Phe
        35                  40                  45              
Phe Gln Arg Asp Ala Glu Glu Leu Glu Lys Trp Ile Gln Glu Lys Leu
    50                  55                  60                  
Gln Ile Ala Ser Asp Glu Asn Tyr Lys Asp Pro Thr Asn Leu Gln Gly
65                  70                  75                  80  
Lys Leu Gln Lys His Gln Ala Phe Glu Ala Glu Val Gln Ala Asn Ser
                85                  90                  95      
Gly Ala Ile Val Lys Leu Asp Glu Thr Gly Asn Leu Met Ile Ser Glu
            100                 105                 110         
Gly His Phe Ala Ser Glu Thr Ile Arg Thr Arg Leu Met Glu Leu His
        115                 120                 125             
Arg Gln Trp Glu Leu Leu Leu Glu Lys Met Arg Glu Lys Gly Ile Lys
    130                 135                 140                 
Leu Leu Gln Ala Gln Lys Leu Val Gln Tyr Leu Arg Glu Cys Glu Asp
145                 150                 155                 160 
Val Met Asp Trp Ile Asn Asp Lys Glu Ala Ile Val Thr Ser Glu Glu
                165                 170                 175     
Leu Gly Gln Asp Leu Glu His Val Glu Val Leu Gln Lys Lys Phe Glu
            180                 185                 190         
Glu Phe Gln Thr Asp Met Ala Ala His Glu Glu Arg Val Asn Glu Val
        195                 200                 205             
Asn Gln Phe Ala Ala Lys Leu Ile Gln Glu Gln His Pro Glu Glu Glu
    210                 215                 220                 
Leu Ile Lys Thr Lys Gln Asp Glu Val Asn Ala Ala Trp Gln Arg Leu
225                 230                 235                 240 
Lys Gly Leu Ala Leu Gln Arg Gln Gly Lys Leu Phe Gly Ala Ala Glu
                245                 250                 255     
Val Gln Arg Phe Asn Arg Asp Val Asp Glu Thr Ile Ser Trp Ile Lys
            260                 265                 270         
Glu Lys Glu Gln Leu Met Ala Ser Asp Asp Phe Gly Arg Asp Leu Ala
        275                 280                 285             
Ser Val Gln Ala Leu Leu Arg Lys His Glu Gly Leu Glu Arg Asp Leu
    290                 295                 300                 
Ala Ala Leu Glu Asp Lys Val Lys Ala Leu Cys Ala Glu Ala Asp Arg
305                 310                 315                 320 
Leu Gln Gln Ser His Pro Leu Ser Ala Thr Gln Ile Gln Val Lys Arg
                325                 330                 335     
Glu Glu Leu Ile Thr Asn Trp Glu Gln Ile Arg Thr Leu Ala Ala Glu
            340                 345                 350         
Arg His Ala Arg Leu Asn Asp Ser Tyr Arg Leu Gln Arg Phe Leu Ala
        355                 360                 365             
Asp Phe Arg Asp Leu Thr Ser Trp Val Thr Glu Met Lys Ala Leu Ile
    370                 375                 380                 
Asn Ala Asp Glu Leu Ala Ser Asp Val Ala Gly Ala Glu Ala Leu Leu
385                 390                 395                 400 
Asp Arg His Gln Glu His Lys Gly Glu Ile Asp Ala His Glu Asp Ser
                405                 410                 415     
Phe Lys Ser Ala Asp Glu Ser Gly Gln Ala Leu Leu Ala Ala Gly His
            420                 425                 430         
Tyr Ala Ser Asp Glu Val Arg Glu Lys Leu Thr Val Leu Ser Glu Glu
        435                 440                 445             
Arg Ala Ala Leu Leu Glu Leu Trp Glu Leu Arg Arg Gln Gln Tyr Glu
    450                 455                 460                 
Gln Cys Met Asp Leu Gln Leu Phe Tyr Arg Asp Thr Glu Gln Val Asp
465                 470                 475                 480 
Asn Trp Met Ser Lys Gln Glu Ala Phe Leu Leu Asn Glu Asp Leu Gly
                485                 490                 495     
Asp Ser Leu Asp Ser Val Glu Ala Leu Leu Lys Lys His Glu Asp Phe
            500                 505                 510         
Glu Lys Ser Leu Ser Ala Gln Glu Glu Lys Ile Thr Ala Leu Asp Glu
        515                 520                 525             
Phe Ala Thr Lys Leu Ile Gln Asn Asn His Tyr Ala Met Glu Asp Val
    530                 535                 540                 
Ala Thr Arg Arg Asp Ala Leu Leu Ser Arg Arg Asn Ala Leu His Glu
545                 550                 555                 560 
Arg Ala Met Arg Arg Arg Ala Gln Leu Ala Asp Ser Phe His Leu Gln
                565                 570                 575     
Gln Phe Phe Arg Asp Ser Asp Glu Leu Lys Ser Trp Val Asn Glu Lys
            580                 585                 590         
Met Lys Thr Ala Thr Asp Glu Ala Tyr Lys Asp Pro Ser Asn Leu Gln
        595                 600                 605             
Gly Lys Val Gln Lys His Gln Ala Phe Glu Ala Glu Leu Ser Ala Asn
    610                 615                 620                 
Gln Ser Arg Ile Asp Ala Leu Glu Lys Ala Gly Gln Lys Leu Ile Asp
625                 630                 635                 640 
Val Asn His Tyr Ala Lys Asp Glu Val Ala Ala Arg Met Asn Glu Val
                645                 650                 655     
Ile Ser Leu Trp Lys Lys Leu Leu Glu Ala Thr Glu Leu Lys Gly Ile
            660                 665                 670         
Lys Leu Arg Glu Ala Asn Gln Gln Gln Gln Phe Asn Arg Asn Val Glu
        675                 680                 685             
Asp Ile Glu Leu Trp Leu Tyr Glu Val Glu Gly His Leu Ala Ser Asp
    690                 695                 700                 
Asp Tyr Gly Lys Asp Leu Thr Asn Val Gln Asn Leu Gln Lys Lys His
705                 710                 715                 720 
Ala Leu Leu Glu Ala Asp Val Ala Ala His Gln Asp Arg Ile Asp Gly
                725                 730                 735     
Ile Thr Ile Gln Ala Arg Gln Phe Gln Asp Ala Gly His Phe Asp Ala
            740                 745                 750         
Glu Asn Ile Lys Lys Lys Gln Glu Ala Leu Val Ala Arg Tyr Glu Ala
        755                 760                 765             
Leu Lys Glu Pro Met Val Ala Arg Lys Gln Lys Leu Ala Asp Ser Leu
    770                 775                 780                 
Arg Leu Gln Gln Leu Phe Arg Asp Val Glu Asp Glu Glu Thr Trp Ile
785                 790                 795                 800 
Arg Glu Lys Glu Pro Ile Ala Ala Ser Thr Asn Arg Gly Lys Asp Leu
                805                 810                 815     
Ile Gly Val Gln Asn Leu Leu Lys Lys His Gln Ala Leu Gln Ala Glu
            820                 825                 830         
Ile Ala Gly His Glu Pro Arg Ile Lys Ala Val Thr Gln Lys Gly Asn
        835                 840                 845             
Ala Met Val Glu Glu Gly His Phe Ala Ala Glu Asp Val Lys Ala Lys
    850                 855                 860                 
Leu His Glu Leu Asn Gln Lys Trp Glu Ala Leu Lys Ala Lys Ala Ser
865                 870                 875                 880 
Gln Arg Arg Gln Asp Leu Glu Asp Ser Leu Gln Ala Gln Gln Tyr Phe
                885                 890                 895     
Ala Asp Ala Asn Glu Ala Glu Ser Trp Met Arg Glu Lys Glu Pro Ile
            900                 905                 910         
Val Gly Ser Thr Asp Tyr Gly Lys Asp Glu Asp Ser Ala Glu Ala Leu
        915                 920                 925             
Leu Lys Lys His Glu Ala Leu Met Ser Asp Leu Ser Ala Tyr Gly Ser
    930                 935                 940                 
Ser Ile Gln Ala Leu Arg Glu Gln Ala Gln Ser Cys Arg Gln Gln Val
945                 950                 955                 960 
Ala Pro Thr Asp Asp Glu Thr Gly Lys Glu Leu Val Leu Ala Leu Tyr
                965                 970                 975     
Asp Tyr Gln Glu Lys Ser Pro Arg Glu Val Thr Met Lys Lys Gly Asp
            980                 985                 990         
Ile Leu Thr Leu Leu Asn Ser Thr Asn Lys Asp Trp Trp Lys Val Glu
        995                 1000                1005            
Val Asn Asp Arg Gln Gly Phe Val Pro Ala Ala Tyr Val Lys Lys Leu
    1010                1015                1020                
Asp Pro Ala Gln Ser Ala Ser Arg Glu Asn Leu Leu Glu Glu Gln Gly
1025                1030                1035                1040
Ser Ile Ala Leu Arg Gln Glu Gln Ile Asp Asn Gln Thr Arg Ile Thr
                1045                1050                1055    
Lys Glu Ala Gly Ser Val Ser Leu Arg Met Lys Gln Val Glu Glu Leu
            1060                1065                1070        
Tyr His Ser Leu Leu Glu Leu Gly Glu Lys Arg Lys Gly Met Leu Glu
        1075                1080                1085            
Lys Ser Cys Lys Lys Phe Met Leu Phe Arg Glu Ala Asn Glu Leu Gln
    1090                1095                1100                
Gln Trp Ile Asn Glu Lys Glu Ala Ala Leu Thr Ser Glu Glu Val Gly
1105                1110                1115                1120
Ala Asp Leu Glu Gln Val Glu Val Leu Gln Lys Lys Phe Asp Asp Phe
                1125                1130                1135    
Gln Lys Asp Leu Lys Ala Asn Glu Ser Arg Leu Lys Asp Ile Asn Lys
            1140                1145                1150        
Val Ala Glu Asp Leu Glu Ser Glu Gly Leu Met Ala Glu Glu Val Gln
        1155                1160                1165            
Ala Val Gln Gln Gln Glu Val Tyr Gly Met Met Pro Arg Asp Glu Thr
    1170                1175                1180                
Asp Ser Lys Thr Ala Ser Pro Trp Lys Ser Ala Arg Leu Met Val His
1185                1190                1195                1200
Thr Val Ala Thr Phe Asn Ser Ile Lys Glu Leu Asn Glu Arg Trp Arg
                1205                1210                1215    
Ser Leu Gln Gln Leu Ala Glu Glu Arg Ser Gln Leu Leu Gly Ser Ala
            1220                1225                1230        
His Glu Val Gln Arg Phe His Arg Asp Ala Asp Glu Thr Lys Glu Trp
        1235                1240                1245            
Ile Glu Glu Lys Asn Gln Ala Leu Asn Thr Asp Asn Tyr Gly His Asp
    1250                1255                1260                
Leu Ala Ser Val Gln Ala Leu Gln Arg Lys His Glu Gly Phe Glu Arg
1265                1270                1275                1280
Asp Leu Ala Ala Leu Gly Asp Lys Val Asn Ser Leu Gly Glu Thr Ala
                1285                1290                1295    
Glu Arg Leu Ile Gln Ser His Pro Glu Ser Ala Glu Asp Leu Gln Glu
            1300                1305                1310        
Lys Cys Thr Glu Leu Asn Gln Ala Trp Ser Ser Leu Gly Lys Arg Ala
        1315                1320                1325            
Asp Gln Arg Lys Ala Lys Leu Gly Asp Ser His Asp Leu Gln Arg Phe
    1330                1335                1340                
Leu Ser Asp Phe Arg Asp Leu Met Ser Trp Ile Asn Gly Ile Arg Gly
1345                1350                1355                1360
Leu Val Ser Ser Asp Glu Leu Ala Lys Asp Val Thr Gly Ala Glu Ala
                1365                1370                1375    
Leu Leu Glu Arg His Gln Glu His Arg Thr Glu Ile Asp Ala Arg Ala
            1380                1385                1390        
Gly Thr Phe Gln Ala Phe Glu Gln Phe Gly Gln Gln Leu Leu Ala His
        1395                1400                1405            
Gly His Tyr Ala Ser Pro Glu Ile Lys Gln Lys Leu Asp Ile Leu Asp
    1410                1415                1420                
Gln Glu Arg Ala Asp Leu Glu Lys Ala Trp Val Gln Arg Arg Met Met
1425                1430                1435                1440
Leu Asp Gln Cys Leu Glu Leu Gln Leu Phe His Arg Asp Cys Glu Gln
                1445                1450                1455    
Ala Glu Asn Trp Met Ala Ala Arg Glu Ala Phe Leu Asn Thr Glu Asp
            1460                1465                1470        
Lys Gly Asp Ser Leu Asp Ser Val Glu Ala Leu Ile Lys Lys His Glu
        1475                1480                1485            
Asp Phe Asp Lys Ala Ile Asn Val Gln Glu Glu Lys Ile Ala Ala Leu
    1490                1495                1500                
Gln Ala Phe Ala Asp Gln Leu Ile Ala Ala Gly His Tyr Ala Lys Gly
1505                1510                1515                1520
Asp Ile Ser Ser Arg Arg Asn Glu Val Leu Asp Arg Trp Arg Arg Leu
                1525                1530                1535    
Lys Ala Gln Met Ile Glu Lys Arg Ser Lys Leu Gly Glu Ser Gln Thr
            1540                1545                1550        
Leu Gln Gln Phe Ser Arg Asp Val Asp Glu Ile Glu Ala Trp Ile Ser
        1555                1560                1565            
Glu Lys Leu Gln Thr Ala Ser Asp Glu Ser Tyr Lys Asp Pro Thr Asn
    1570                1575                1580                
Ile Gln Leu Ser Lys Leu Leu Ser Lys His Gln Lys His Gln Ala Phe
1585                1590                1595                1600
Glu Ala Glu Leu His Ala Asn Ala Asp Arg Ile Arg Gly Val Ile Asp
                1605                1610                1615    
Met Gly Asn Ser Leu Ile Glu Arg Gly Ala Cys Ala Gly Ser Glu Asp
            1620                1625                1630        
Ala Val Lys Ala Arg Leu Ala Ala Leu Ala Asp Gln Trp Gln Phe Leu
        1635                1640                1645            
Val Gln Lys Ser Ala Glu Lys Ser Gln Lys Leu Lys Glu Ala Asn Lys
    1650                1655                1660                
Gln Gln Asn Phe Asn Thr Gly Ile Lys Asp Phe Asp Phe Trp Leu Ser
1665                1670                1675                1680
Glu Val Glu Ala Leu Leu Ala Ser Glu Asp Tyr Gly Lys Asp Leu Ala
                1685                1690                1695    
Ser Val Asn Asn Leu Leu Lys Lys His Gln Leu Leu Glu Ala Asp Ile
            1700                1705                1710        
Ser Ala His Glu Asp Arg Leu Lys Asp Leu Asn Ser Gln Ala Asp Ser
        1715                1720                1725            
Leu Met Thr Ser Ser Ala Phe Asp Thr Ser Gln Val Lys Asp Lys Arg
    1730                1735                1740                
Asp Thr Ile Asn Gly Arg Phe Gln Lys Ile Lys Ser Met Ala Ala Ser
1745                1750                1755                1760
Arg Arg Ala Lys Leu Asn Glu Ser His Arg Leu His Gln Phe Phe Arg
                1765                1770                1775    
Asp Met Asp Asp Glu Glu Ser Trp Ile Lys Glu Lys Lys Leu Leu Val
            1780                1785                1790        
Gly Ser Glu Asp Tyr Gly Arg Asp Leu Thr Gly Val Gln Asn Leu Arg
        1795                1800                1805            
Lys Lys His Lys Arg Leu Glu Ala Glu Leu Ala Ala His Glu Pro Ala
    1810                1815                1820                
Ile Gln Gly Val Leu Asp Thr Gly Lys Lys Leu Ser Asp Asp Asn Thr
1825                1830                1835                1840
Ile Gly Lys Glu Glu Ile Gln Gln Arg Leu Ala Gln Phe Val Glu His
                1845                1850                1855    
Trp Lys Glu Leu Lys Gln Leu Ala Ala Ala Arg Gly Gln Arg Leu Glu
            1860                1865                1870        
Glu Ser Leu Glu Tyr Gln Gln Phe Val Ala Asn Val Glu Glu Glu Glu
        1875                1880                1885            
Ala Trp Ile Asn Glu Lys Met Thr Leu Val Ala Ser Glu Asp Tyr Gly
    1890                1895                1900                
Asp Thr Leu Ala Ala Ile Gln Gly Leu Leu Lys Lys His Glu Ala Phe
1905                1910                1915                1920
Glu Thr Asp Phe Thr Val His Lys Asp Arg Val Asn Asp Val Cys Thr
                1925                1930                1935    
Asn Gly Gln Asp Leu Ile Lys Lys Asn Asn His His Glu Glu Asn Ile
            1940                1945                1950        
Ser Ser Lys Met Lys Gly Leu Asn Gly Lys Val Ser Asp Leu Glu Lys
        1955                1960                1965            
Ala Ala Ala Gln Arg Lys Ala Asn Val Asp Glu Asn Ser Ala Phe Leu
    1970                1975                1980                
Gln Phe Asn Trp Lys Ala Asp Val Val Glu Ser Trp Ile Gly Glu Lys
1985                1990                1995                2000
Glu Asn Ser Leu Lys Thr Asp Asp Tyr Gly Arg Asp Leu Ser Ser Val
                2005                2010                2015    
Gln Thr Leu Leu Thr Lys Gln Glu Thr Phe Asp Ala Gly Leu Gln Ala
            2020                2025                2030        
Phe Gln Gln Glu Gly Ile Ala Asn Ile Thr Ala Leu Lys Asp Gln Leu
        2035                2040                2045            
Leu Ala Ala Lys His Val Gln Ser Lys Ala Ile Glu Ala Arg His Ala
    2050                2055                2060                
Ser Leu Met Lys Arg Trp Ser Gln Leu Leu Ala Asn Ser Ala Ala Arg
2065                2070                2075                2080
Lys Lys Lys Leu Leu Glu Ala Gln Ser His Phe Arg Lys Val Glu Asp
                2085                2090                2095    
Leu Phe Leu Thr Phe Ala Lys Lys Ala Ser Ala Phe Asn Ser Trp Phe
            2100                2105                2110        
Glu Asn Ala Glu Glu Asp Leu Thr Asp Pro Val Arg Cys Asn Ser Leu
        2115                2120                2125            
Glu Glu Ile Lys Ala Leu Arg Glu Ala His Asp Ala Phe Arg Ser Ser
    2130                2135                2140                
Leu Ser Ser Ala Gln Ala Asp Phe Asn Gln Leu Ala Glu Leu Asp Arg
2145                2150                2155                2160
Gln Ile Lys Ser Phe Arg Val Ala Ser Asn Pro Tyr Thr Trp Phe Thr
                2165                2170                2175    
Met Glu Ala Leu Glu Glu Thr Trp Arg Asn Leu Gln Lys Ile Ile Lys
            2180                2185                2190        
Glu Arg Glu Leu Glu Leu Gln Lys Glu Gln Arg Arg Gln Glu Glu Asn
        2195                2200                2205            
Asp Lys Leu Arg Gln Glu Phe Ala Gln His Ala Asn Ala Phe His Gln
    2210                2215                2220                
Trp Ile Gln Glu Thr Arg Thr Tyr Leu Leu Asp Gly Ser Cys Met Val
2225                2230                2235                2240
Glu Glu Ser Gly Thr Leu Glu Ser Gln Leu Glu Ala Thr Lys Arg Lys
                2245                2250                2255    
His Gln Glu Ile Arg Ala Met Arg Ser Gln Leu Lys Lys Ile Glu Asp
            2260                2265                2270        
Leu Gly Ala Ala Met Glu Glu Ala Leu Ile Leu Asp Asn Lys Tyr Thr
        2275                2280                2285            
Glu His Ser Thr Val Gly Leu Ala Gln Gln Trp Asp Gln Leu Asp Gln
    2290                2295                2300                
Leu Gly Met Arg Met Gln His Asn Leu Glu Gln Gln Ile Gln Ala Arg
2305                2310                2315                2320
Asn Thr Thr Gly Val Thr Glu Glu Ala Leu Lys Glu Phe Ser Met Met
                2325                2330                2335    
Phe Lys His Phe Asp Lys Asp Lys Ser Gly Arg Leu Asn His Gln Glu
            2340                2345                2350        
Phe Lys Ser Cys Leu Arg Ser Leu Gly Tyr Asp Leu Pro Met Val Glu
        2355                2360                2365            
Glu Gly Glu Pro Asp Pro Glu Phe Glu Ala Ile Leu Asp Thr Val Asp
    2370                2375                2380                
Pro Asn Arg Asp Gly His Val Ser Leu Gln Glu Tyr Met Ala Phe Met
2385                2390                2395                2400
Ile Ser Arg Glu Thr Glu Asn Val Lys Ser Ser Glu Glu Ile Glu Ser
                2405                2410                2415    
Ala Phe Arg Ala Leu Ser Ser Glu Gly Lys Pro Tyr Val Thr Lys Glu
            2420                2425                2430        
Glu Leu Tyr Gln Asn Leu Thr Arg Glu Gln Ala Asp Tyr Cys Val Ser
        2435                2440                2445            
His Met Lys Pro Tyr Val Asp Gly Lys Gly Arg Glu Leu Pro Thr Ala
    2450                2455                2460                
Phe Asp Tyr Val Glu Phe Thr Arg Ser Leu Phe Val Asn
2465                2470                2475        


<210> 239
<211> 133
<212> PRT
<213> Homo sapiens

<400> 239
Met Ala Asp Ala Phe Leu Gly Thr Trp Lys Leu Val Asp Ser Lys Asn
 1               5                  10                  15      
Phe Asp Asp Tyr Met Lys Ser Leu Gly Val Gly Phe Ala Thr Arg Gln
            20                  25                  30          
Val Ala Ser Met Thr Lys Pro Thr Thr Ile Ile Glu Lys Asn Gly Asp
        35                  40                  45              
Ile Leu Thr Leu Lys Thr His Ser Thr Phe Lys Asn Thr Glu Ile Ser
    50                  55                  60                  
Phe Lys Leu Gly Val Glu Phe Asp Glu Thr Thr Ala Asp Asp Arg Lys
65                  70                  75                  80  
Val Lys Ser Ile Val Thr Leu Asp Gly Gly Lys Leu Val His Leu Gln
                85                  90                  95      
Lys Trp Asp Gly Gln Glu Thr Thr Leu Val Arg Glu Leu Ile Asp Gly
            100                 105                 110         
Lys Leu Ile Leu Thr Leu Thr His Gly Thr Ala Val Cys Thr Arg Thr
        115                 120                 125             
Tyr Glu Lys Glu Ala
    130             


<210> 240
<211> 233
<212> PRT
<213> Homo sapiens

<400> 240
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Thr Val Ala Pro
            20                  25                  30          
Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Thr Met Asn Leu Ser
        35                  40                  45              
Trp Asp Cys Gln Glu Asn Thr Thr Phe Ser Lys Cys Phe Leu Thr Asp
    50                  55                  60                  
Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser
65                  70                  75                  80  
Cys Thr Phe Arg Glu Ile Cys Leu His Glu Gly Val Thr Phe Glu Val
                85                  90                  95      
His Val Asn Thr Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro
            100                 105                 110         
Asn Ser Gly Arg Glu Gly Thr Ala Ala Gln Asn Phe Ser Cys Phe Ile
        115                 120                 125             
Tyr Asn Ala Asp Leu Met Asn Cys Thr Trp Ala Arg Gly Pro Thr Ala
    130                 135                 140                 
Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg
145                 150                 155                 160 
Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Thr His Val
                165                 170                 175     
Gly Cys His Leu Asp Asn Leu Ser Gly Leu Thr Ser Arg Asn Tyr Phe
            180                 185                 190         
Leu Val Asn Gly Thr Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser
        195                 200                 205             
Leu Leu Asp Thr Lys Lys Ile Gly Ser Leu Gly Tyr Ser Gly Cys Ser
    210                 215                 220                 
Arg Gln Phe His Arg Ser Lys Thr Asn
225                 230             


<210> 241
<211> 333
<212> PRT
<213> Homo sapiens

<400> 241
Arg Arg Arg Arg Ser Val Gln Trp Cys Ala Val Ser Gln Pro Glu Ala
 1               5                  10                  15      
Thr Lys Cys Phe Gln Trp Gln Arg Asn Met Arg Arg Val Arg Gly Pro
            20                  25                  30          
Pro Val Ser Cys Ile Lys Arg Asp Ser Pro Ile Gln Cys Ile Gln Ala
        35                  40                  45              
Ile Ala Glu Asn Arg Ala Asp Ala Val Thr Leu Asp Gly Gly Phe Ile
    50                  55                  60                  
Tyr Glu Ala Gly Leu Ala Pro Tyr Lys Leu Arg Pro Val Ala Ala Glu
65                  70                  75                  80  
Val Tyr Gly Thr Glu Arg Gln Pro Arg Thr His Tyr Tyr Ala Val Ala
                85                  90                  95      
Val Val Lys Lys Gly Gly Ser Phe Gln Leu Asn Glu Leu Gln Gly Leu
            100                 105                 110         
Lys Ser Cys His Thr Gly Leu Arg Arg Thr Ala Gly Trp Asn Val Pro
        115                 120                 125             
Ile Gly Thr Leu Arg Pro Phe Leu Asn Trp Thr Gly Pro Pro Glu Pro
    130                 135                 140                 
Ile Glu Ala Ala Val Ala Arg Phe Phe Ser Ala Ser Cys Val Pro Gly
145                 150                 155                 160 
Ala Asp Lys Gly Gln Phe Pro Asn Leu Cys Arg Leu Cys Ala Gly Thr
                165                 170                 175     
Gly Glu Asn Lys Cys Ala Phe Ser Ser Gln Glu Pro Tyr Phe Ser Tyr
            180                 185                 190         
Ser Gly Ala Phe Lys Cys Leu Arg Asp Gly Ala Gly Asp Val Ala Phe
        195                 200                 205             
Ile Arg Glu Ser Thr Val Phe Glu Asp Leu Ser Asp Glu Ala Glu Arg
    210                 215                 220                 
Asp Glu Tyr Glu Leu Leu Cys Pro Asp Asn Thr Arg Lys Pro Val Asp
225                 230                 235                 240 
Lys Phe Lys Asp Cys His Leu Ala Arg Val Pro Ser Met Ala Val Val
                245                 250                 255     
Ala Arg Ser Val Asn Gly Lys Glu Asp Ala Ile Trp Asn Leu Leu Arg
            260                 265                 270         
Gln Ala Gln Glu Lys Phe Gly Lys Asp Lys Ser Pro Lys Phe Gln Leu
        275                 280                 285             
Phe Gly Ser Pro Ser Gly Gln Lys Asp Leu Leu Phe Lys Asp Ser Ala
    290                 295                 300                 
Ile Gly Phe Ser Arg Val Pro Pro Arg Ile Asp Ser Gly Leu Tyr Leu
305                 310                 315                 320 
Gly Ser Gly Tyr Phe Thr Ala Ile Asn Leu Arg Lys Ser
                325                 330             


<210> 242
<211> 139
<212> PRT
<213> Homo sapiens

<400> 242
Ala Gly Trp Asn Ala Tyr Ile Asp Asn Leu Met Ala Asp Gly Thr Cys
 1               5                  10                  15      
Gln Asp Ala Ala Ile Val Gly Tyr Lys Asp Ser Pro Ser Val Trp Ala
            20                  25                  30          
Ala Val Pro Gly Lys Thr Phe Val Asn Ile Thr Pro Ala Glu Val Gly
        35                  40                  45              
Val Leu Val Gly Lys Asp Arg Ser Ser Phe Tyr Val Asn Gly Leu Thr
    50                  55                  60                  
Leu Gly Gly Gln Lys Cys Ser Val Ile Arg Asp Ser Leu Leu Gln Asp
65                  70                  75                  80  
Gly Glu Phe Ser Met Asp Leu Arg Thr Lys Ser Thr Gly Gly Ala Pro
                85                  90                  95      
Thr Phe Asn Val Thr Val Thr Lys Thr Asp Lys Thr Leu Val Leu Leu
            100                 105                 110         
Met Gly Lys Glu Gly Val His Gly Gly Leu Ile Asn Lys Lys Cys Tyr
        115                 120                 125             
Glu Met Ala Ser His Leu Arg Arg Ser Gln Tyr
    130                 135                 


<210> 243
<211> 390
<212> PRT
<213> Homo sapiens

<400> 243
Met Gly Arg Ala Gly Leu Glu Ala Pro Pro Pro Pro Cys Gly Val Thr
 1               5                  10                  15      
Gly Thr Pro Gly Ala Arg Gly Leu Gln Gly Arg Val Gly Pro Arg Pro
            20                  25                  30          
Gln Ser Leu Ala Phe Arg Gly Cys Leu Pro Arg Ala Ser Ser Leu Pro
        35                  40                  45              
Gly Ser Pro Arg Cys Arg Arg Arg Cys His Thr Met Ala Phe Val Thr
    50                  55                  60                  
Arg Gln Phe Met Arg Ser Val Ser Ser Ser Ser Thr Ala Ser Ala Ser
65                  70                  75                  80  
Ala Lys Lys Ile Ile Val Lys His Val Thr Val Ile Gly Gly Gly Leu
                85                  90                  95      
Met Gly Ala Gly Ile Ala Gln Val Ala Ala Ala Thr Gly His Thr Val
            100                 105                 110         
Val Leu Val Asp Gln Thr Glu Asp Ile Leu Ala Lys Ser Lys Lys Gly
        115                 120                 125             
Ile Glu Glu Ser Leu Arg Lys Val Ala Lys Lys Lys Phe Ala Glu Asn
    130                 135                 140                 
Pro Lys Ala Gly Asp Glu Phe Val Glu Lys Thr Leu Ser Thr Ile Ala
145                 150                 155                 160 
Thr Ser Thr Asp Ala Ala Ser Val Val His Ser Thr Asp Leu Val Val
                165                 170                 175     
Glu Ala Ile Val Glu Asn Leu Lys Val Lys Asn Glu Leu Phe Lys Arg
            180                 185                 190         
Leu Asp Lys Phe Ala Ala Glu His Thr Ile Phe Ala Ser Asn Thr Ser
        195                 200                 205             
Ser Leu Gln Ile Thr Ser Ile Ala Asn Ala Thr Thr Arg Gln Asp Arg
    210                 215                 220                 
Phe Ala Gly Leu His Phe Phe Asn Pro Val Pro Val Met Lys Leu Val
225                 230                 235                 240 
Glu Val Ile Lys Thr Pro Met Thr Ser Gln Lys Thr Phe Glu Ser Leu
                245                 250                 255     
Val Asp Phe Ser Lys Ala Leu Gly Lys His Pro Val Ser Cys Lys Asp
            260                 265                 270         
Thr Pro Gly Phe Ile Val Asn Arg Leu Leu Val Pro Tyr Leu Met Glu
        275                 280                 285             
Ala Ile Arg Leu Tyr Glu Arg Asp Phe Gln Thr Cys Gly Asp Ser Asn
    290                 295                 300                 
Ser Gly Leu Gly Phe Ser Leu Lys Gly Asp Ala Ser Lys Glu Asp Ile
305                 310                 315                 320 
Asp Thr Ala Met Lys Leu Gly Ala Gly Tyr Pro Met Gly Pro Phe Glu
                325                 330                 335     
Leu Leu Asp Tyr Val Gly Leu Asp Thr Thr Lys Phe Ile Val Asp Gly
            340                 345                 350         
Trp His Glu Met Asp Ala Glu Asn Pro Leu His Gln Pro Ser Pro Ser
        355                 360                 365             
Leu Asn Lys Leu Val Ala Glu Asn Lys Phe Gly Lys Lys Thr Gly Glu
    370                 375                 380                 
Gly Phe Tyr Lys Tyr Lys
385                 390 


<210> 244
<211> 263
<212> PRT
<213> Homo sapiens

<400> 244
Met Leu Leu Ala Trp Val Gln Ala Phe Leu Val Ser Asn Met Leu Leu
 1               5                  10                  15      
Ala Glu Ala Tyr Gly Ser Gly Gly Cys Phe Trp Asp Asn Gly His Leu
            20                  25                  30          
Tyr Arg Glu Asp Gln Thr Ser Pro Ala Pro Gly Leu Arg Cys Leu Asn
        35                  40                  45              
Trp Leu Asp Ala Gln Ser Gly Leu Ala Ser Ala Pro Val Ser Gly Ala
    50                  55                  60                  
Gly Asn His Ser Tyr Cys Arg Asn Pro Asp Glu Asp Pro Arg Gly Pro
65                  70                  75                  80  
Trp Cys Tyr Val Ser Gly Glu Ala Gly Val Pro Glu Lys Arg Pro Cys
                85                  90                  95      
Glu Asp Leu Arg Cys Pro Glu Thr Thr Ser Gln Ala Leu Pro Ala Phe
            100                 105                 110         
Thr Thr Glu Ile Gln Glu Ala Ser Glu Gly Pro Gly Ala Asp Glu Val
        115                 120                 125             
Gln Val Phe Ala Pro Ala Asn Ala Leu Pro Ala Arg Ser Glu Ala Ala
    130                 135                 140                 
Ala Val Gln Pro Val Ile Gly Ile Ser Gln Arg Val Arg Met Asn Ser
145                 150                 155                 160 
Lys Glu Lys Lys Asp Leu Gly Thr Leu Gly Tyr Val Leu Gly Ile Thr
                165                 170                 175     
Met Met Val Ile Ile Ile Ala Ile Gly Ala Gly Ile Ile Leu Gly Tyr
            180                 185                 190         
Ser Tyr Lys Arg Gly Lys Asp Leu Lys Glu Gln His Asp Gln Lys Val
        195                 200                 205             
Cys Glu Arg Glu Met Gln Arg Ile Thr Leu Pro Leu Ser Ala Phe Thr
    210                 215                 220                 
Asn Pro Thr Cys Glu Ile Val Asp Glu Lys Thr Val Val Val His Thr
225                 230                 235                 240 
Ser Gln Thr Pro Val Asp Pro Gln Glu Gly Thr Thr Pro Leu Met Gly
                245                 250                 255     
Gln Ala Gly Thr Pro Gly Ala
            260             


<210> 245
<211> 741
<212> PRT
<213> Homo sapiens

<400> 245
Met Asp Ile Glu Asp Glu Glu Asn Met Ser Ser Ser Ser Thr Asp Val
 1               5                  10                  15      
Lys Glu Asn Arg Asn Leu Asp Asn Val Ser Pro Lys Asp Ala Ser Thr
            20                  25                  30          
Pro Gly Pro Gly Glu Gly Ser Gln Leu Ser Asn Gly Gly Gly Gly Gly
        35                  40                  45              
Pro Gly Arg Lys Arg Pro Leu Glu Glu Gly Ser Asn Gly His Ser Lys
    50                  55                  60                  
Tyr Arg Leu Lys Lys Arg Arg Lys Thr Pro Gly Pro Val Leu Pro Lys
65                  70                  75                  80  
Asn Ala Leu Met Gln Leu Asn Glu Ile Lys Pro Gly Leu Gln Tyr Thr
                85                  90                  95      
Leu Leu Ser Gln Thr Gly Pro Val His Ala Pro Leu Phe Val Met Ser
            100                 105                 110         
Val Glu Val Asn Gly Gln Val Phe Glu Gly Ser Gly Pro Thr Lys Lys
        115                 120                 125             
Lys Ala Lys Leu His Ala Ala Glu Lys Ala Leu Arg Ser Phe Val Gln
    130                 135                 140                 
Phe Pro Asn Ala Ser Glu Ala His Leu Ala Met Gly Arg Thr Leu Ser
145                 150                 155                 160 
Val Asn Thr Asp Phe Thr Ser Asp Gln Ala Asp Phe Pro Asp Thr Leu
                165                 170                 175     
Phe Asn Gly Phe Glu Thr Pro Asp Lys Ala Glu Pro Pro Phe Tyr Val
            180                 185                 190         
Gly Ser Asn Gly Asp Asp Ser Phe Ser Ser Ser Gly Asp Leu Ser Leu
        195                 200                 205             
Ser Ala Ser Pro Val Pro Ala Ser Leu Ala Gln Pro Pro Leu Pro Val
    210                 215                 220                 
Leu Pro Pro Phe Pro Pro Pro Ser Gly Lys Asn Pro Val Met Ile Leu
225                 230                 235                 240 
Asn Glu Leu Arg Pro Gly Leu Lys Tyr Asp Phe Leu Ser Glu Ser Gly
                245                 250                 255     
Glu Ser His Ala Lys Ser Phe Val Met Ser Val Val Val Asp Gly Gln
            260                 265                 270         
Phe Phe Glu Gly Ser Gly Arg Asn Lys Lys Leu Ala Lys Ala Arg Ala
        275                 280                 285             
Ala Gln Ser Ala Leu Ala Ala Ile Phe Asn Leu His Leu Asp Gln Thr
    290                 295                 300                 
Pro Ser Arg Gln Pro Ile Pro Ser Glu Gly Leu Gln Leu His Leu Pro
305                 310                 315                 320 
Gln Val Leu Ala Asp Ala Val Ser Arg Leu Val Leu Gly Lys Phe Gly
                325                 330                 335     
Asp Leu Thr Asp Asn Phe Ser Ser Pro His Ala Arg Arg Lys Val Leu
            340                 345                 350         
Ala Gly Val Val Met Thr Thr Gly Thr Asp Val Lys Asp Ala Lys Val
        355                 360                 365             
Ile Ser Val Ser Thr Gly Thr Lys Cys Ile Asn Gly Glu Tyr Met Ser
    370                 375                 380                 
Asp Arg Gly Leu Ala Leu Asn Asp Cys His Ala Glu Ile Ile Ser Arg
385                 390                 395                 400 
Arg Ser Leu Leu Arg Phe Leu Tyr Thr Gln Leu Glu Leu Tyr Leu Asn
                405                 410                 415     
Asn Lys Asp Asp Gln Lys Glu Ser Ile Phe Gln Lys Ser Glu Arg Gly
            420                 425                 430         
Gly Phe Arg Leu Lys Glu Asn Val Gln Phe His Leu Tyr Ile Ser Thr
        435                 440                 445             
Ser Pro Cys Gly Asp Ala Arg Ile Phe Ser Pro His Glu Pro Ile Leu
    450                 455                 460                 
Glu Gly Ser Arg Ser Tyr Thr Gln Ala Gly Leu Gln Trp Cys Asn His
465                 470                 475                 480 
Gly Ser Leu Gln Pro Arg Pro Pro Gly Leu Leu Ser Asp Pro Ser Thr
                485                 490                 495     
Ser Thr Phe Gln Gly Ala Gly Thr Thr Glu Pro Ala Asp Arg His Pro
            500                 505                 510         
Asn Arg Lys Ala Arg Gly Gln Leu Arg Thr Lys Ile Glu Ser Gly Glu
        515                 520                 525             
Gly Thr Ile Pro Val Arg Ser Asn Ala Ser Ile Gln Thr Trp Asp Gly
    530                 535                 540                 
Val Leu Gln Gly Glu Arg Leu Leu Thr Met Ser Cys Ser Asp Lys Ile
545                 550                 555                 560 
Ala Arg Trp Asn Val Val Gly Ile Gln Gly Ser Leu Leu Ser Ile Phe
                565                 570                 575     
Val Glu Pro Ile Tyr Phe Ser Ser Ile Ile Leu Gly Ser Leu Tyr His
            580                 585                 590         
Gly Asp His Leu Ser Arg Ala Met Tyr Gln Arg Ile Ser Asn Ile Glu
        595                 600                 605             
Asp Leu Pro Pro Leu Tyr Thr Leu Asn Lys Pro Leu Leu Ser Gly Ile
    610                 615                 620                 
Ser Asn Ala Glu Ala Arg Gln Pro Gly Lys Ala Pro Asn Phe Ser Val
625                 630                 635                 640 
Asn Trp Thr Val Gly Asp Ser Ala Ile Glu Val Ile Asn Ala Thr Thr
                645                 650                 655     
Gly Lys Asp Glu Leu Gly Arg Ala Ser Arg Leu Cys Lys His Ala Leu
            660                 665                 670         
Tyr Cys Arg Trp Met Arg Val His Gly Lys Val Pro Ser His Leu Leu
        675                 680                 685             
Arg Ser Lys Ile Thr Lys Pro Asn Val Tyr His Glu Ser Lys Leu Ala
    690                 695                 700                 
Ala Lys Glu Tyr Gln Ala Ala Lys Ala Arg Leu Phe Thr Ala Phe Ile
705                 710                 715                 720 
Lys Ala Gly Leu Gly Ala Trp Val Glu Lys Pro Thr Glu Gln Asp Gln
                725                 730                 735     
Phe Ser Leu Thr Pro
            740     


<210> 246
<211> 449
<212> PRT
<213> Homo sapiens

<400> 246
Met Glu Phe Phe Ile Ser Met Ser Glu Thr Ile Lys Tyr Asn Asp Asp
 1               5                  10                  15      
Asp His Lys Thr Leu Phe Leu Lys Thr Leu Asn Glu Gln Arg Leu Glu
            20                  25                  30          
Gly Glu Phe Cys Asp Ile Ala Ile Val Val Glu Asp Val Lys Phe Arg
        35                  40                  45              
Ala His Arg Cys Val Leu Ala Ala Cys Ser Thr Tyr Phe Lys Lys Leu
    50                  55                  60                  
Phe Lys Lys Leu Glu Val Asp Ser Ser Ser Val Ile Glu Ile Asp Phe
65                  70                  75                  80  
Leu Arg Ser Asp Ile Phe Glu Glu Val Leu Asn Tyr Met Tyr Thr Ala
                85                  90                  95      
Lys Ile Ser Val Lys Lys Glu Asp Val Asn Leu Met Met Ser Ser Gly
            100                 105                 110         
Gln Ile Leu Gly Ile Arg Phe Leu Asp Lys Leu Cys Ser Gln Lys Arg
        115                 120                 125             
Asp Val Ser Ser Pro Asp Glu Asn Asn Gly Gln Ser Lys Ser Lys Tyr
    130                 135                 140                 
Cys Leu Lys Ile Asn Arg Pro Ile Gly Asp Ala Ala Asp Thr Gln Asp
145                 150                 155                 160 
Asp Asp Val Glu Glu Ile Gly Asp Gln Asp Asp Ser Pro Ser Asp Asp
                165                 170                 175     
Thr Val Glu Gly Thr Pro Pro Ser Gln Glu Asp Gly Lys Ser Pro Thr
            180                 185                 190         
Thr Thr Leu Arg Val Gln Glu Ala Ile Leu Lys Glu Leu Gly Ser Glu
        195                 200                 205             
Glu Val Arg Lys Val Asn Cys Tyr Gly Gln Glu Val Glu Ser Met Glu
    210                 215                 220                 
Thr Pro Glu Ser Lys Asp Leu Gly Ser Gln Thr Pro Gln Ala Leu Thr
225                 230                 235                 240 
Phe Asn Asp Gly Met Ser Glu Val Lys Asp Glu Gln Thr Pro Gly Trp
                245                 250                 255     
Thr Thr Ala Ala Ser Asp Met Lys Phe Glu Tyr Leu Leu Tyr Gly His
            260                 265                 270         
His Arg Glu Gln Ile Ala Cys Gln Ala Cys Gly Lys Thr Phe Ser Asp
        275                 280                 285             
Glu Gly Arg Leu Arg Lys His Glu Lys Leu His Thr Ala Asp Arg Pro
    290                 295                 300                 
Phe Val Cys Glu Met Cys Thr Lys Gly Phe Thr Thr Gln Ala His Leu
305                 310                 315                 320 
Lys Glu His Leu Lys Ile His Thr Gly Tyr Lys Pro Tyr Ser Cys Glu
                325                 330                 335     
Val Cys Gly Lys Ser Phe Ile Arg Ala Pro Asp Leu Lys Lys His Glu
            340                 345                 350         
Arg Val His Ser Asn Glu Arg Pro Phe Ala Cys His Met Cys Asp Lys
        355                 360                 365             
Ala Phe Lys His Lys Ser His Leu Lys Asp His Glu Arg Arg His Arg
    370                 375                 380                 
Gly Glu Lys Pro Phe Val Cys Gly Ser Cys Thr Lys Ala Phe Ala Lys
385                 390                 395                 400 
Ala Ser Asp Leu Lys Arg His Glu Asn Asn Met His Ser Glu Arg Lys
                405                 410                 415     
Gln Val Thr Pro Ser Ala Ile Gln Ser Glu Thr Glu Gln Leu Gln Ala
            420                 425                 430         
Ala Ala Met Ala Ala Glu Ala Glu Gln Gln Leu Glu Thr Ile Ala Cys
        435                 440                 445             
Ser
    


<210> 247
<211> 256
<212> PRT
<213> Homo sapiens

<400> 247
Met Ala Val Met Ala Pro Arg Thr Leu Val Leu Leu Leu Ser Gly Ala
 1               5                  10                  15      
Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe
            20                  25                  30          
Phe Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala
        35                  40                  45              
Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala
    50                  55                  60                  
Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly
65                  70                  75                  80  
Pro Glu Tyr Trp Asp Gly Glu Thr Arg Lys Val Lys Ala His Ser Gln
                85                  90                  95      
Thr His Arg Val Asp Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser
            100                 105                 110         
Glu Ala Gly Ser His Thr Leu Gln Met Met Phe Gly Cys Asp Val Gly
        115                 120                 125             
Ser Asp Trp Arg Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly
    130                 135                 140                 
Lys Asp Tyr Ile Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala
145                 150                 155                 160 
Asp Met Ala Ala Gln Thr Thr Lys His Lys Trp Glu Ala Ala His Val
                165                 170                 175     
Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu
            180                 185                 190         
Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala
        195                 200                 205             
Pro Lys Thr His Met Thr His His Ala Val Ser Asp His Glu Ala Thr
    210                 215                 220                 
Leu Arg Cys Trp Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr
225                 230                 235                 240 
Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu
                245                 250                 255     


<210> 248
<211> 482
<212> PRT
<213> Homo sapiens

<400> 248
Met Ala Ala Val Arg Met Leu Arg Thr Trp Ser Arg Asn Ala Gly Lys
 1               5                  10                  15      
Leu Ile Cys Val Arg Tyr Phe Gln Thr Cys Gly Asn Val His Val Leu
            20                  25                  30          
Lys Pro Asn Tyr Val Cys Phe Phe Gly Tyr Pro Ser Phe Lys Tyr Ser
        35                  40                  45              
His Pro His His Phe Leu Lys Thr Thr Ala Ala Leu Arg Gly Gln Val
    50                  55                  60                  
Val Gln Phe Lys Leu Ser Asp Ile Gly Glu Gly Ile Arg Glu Val Thr
65                  70                  75                  80  
Val Lys Glu Trp Tyr Val Lys Glu Gly Asp Thr Val Ser Gln Phe Asp
                85                  90                  95      
Ser Ile Cys Glu Val Gln Ser Asp Lys Ala Ser Val Thr Ile Thr Ser
            100                 105                 110         
Arg Tyr Asp Gly Val Ile Lys Lys Leu Tyr Tyr Asn Leu Asp Asp Ile
        115                 120                 125             
Ala Tyr Val Gly Lys Pro Leu Val Asp Ile Glu Thr Glu Ala Leu Lys
    130                 135                 140                 
Asp Ser Glu Glu Asp Val Val Glu Thr Pro Ala Val Ser His Asp Glu
145                 150                 155                 160 
His Thr His Gln Glu Ile Lys Gly Arg Lys Thr Leu Ala Thr Pro Ala
                165                 170                 175     
Val Arg Arg Leu Ala Met Glu Asn Asn Ile Lys Leu Ser Glu Val Val
            180                 185                 190         
Gly Ser Gly Lys Asp Gly Arg Ile Leu Lys Glu Asp Ile Leu Asn Tyr
        195                 200                 205             
Leu Glu Lys Gln Thr Gly Ala Ile Leu Pro Pro Ser Pro Lys Val Glu
    210                 215                 220                 
Ile Met Pro Pro Pro Pro Lys Pro Lys Asp Met Thr Val Pro Ile Leu
225                 230                 235                 240 
Val Ser Lys Pro Pro Val Phe Thr Gly Lys Asp Lys Thr Glu Pro Ile
                245                 250                 255     
Lys Gly Phe Gln Lys Ala Met Val Lys Thr Met Ser Ala Ala Leu Lys
            260                 265                 270         
Ile Pro His Phe Gly Tyr Cys Asp Glu Ile Asp Leu Thr Glu Leu Val
        275                 280                 285             
Lys Leu Arg Glu Glu Leu Lys Pro Ile Ala Phe Ala Arg Gly Ile Lys
    290                 295                 300                 
Leu Ser Phe Met Pro Phe Phe Leu Lys Ala Ala Ser Leu Gly Leu Leu
305                 310                 315                 320 
Pro Phe Pro Ile Leu Asn Ala Ser Val Asp Glu Asn Cys Gln Asn Ile
                325                 330                 335     
Thr Tyr Lys Ala Ser His Asn Ile Gly Ile Ala Met Asp Thr Glu Gln
            340                 345                 350         
Gly Val Ile Val Pro Asn Val Lys Asn Val Gln Ile Cys Ser Ile Phe
        355                 360                 365             
Asp Ile Ala Thr Glu Leu Asn Arg Leu Gln Lys Leu Gly Ser Val Gly
    370                 375                 380                 
Gln Leu Ser Thr Thr Asp Leu Thr Gly Gly Thr Phe Thr Leu Ser Asn
385                 390                 395                 400 
Ile Gly Ser Ile Gly Gly Thr Phe Ala Lys Pro Val Ile Met Pro Pro
                405                 410                 415     
Glu Val Ala Ile Gly Ala Leu Gly Ser Ile Lys Ala Ile Pro Arg Phe
            420                 425                 430         
Asn Gln Lys Gly Glu Val Tyr Lys Ala Gln Ile Met Asn Val Ser Trp
        435                 440                 445             
Ser Ala Asp His Arg Val Ile Asp Gly Ala Thr Met Ser Arg Phe Ser
    450                 455                 460                 
Asn Leu Trp Lys Ser Tyr Leu Glu Asn Pro Ala Phe Met Leu Leu Asp
465                 470                 475                 480 
Leu Lys
        


<210> 249
<211> 531
<212> PRT
<213> Homo sapiens

<400> 249
Met Ser Lys Pro His Ser Glu Ala Gly Thr Ala Phe Ile Gln Thr Gln
 1               5                  10                  15      
Gln Leu His Ala Ala Met Ala Asp Thr Phe Leu Glu His Met Cys Arg
            20                  25                  30          
Leu Asp Ile Asp Ser Pro Pro Ile Thr Ala Arg Asn Thr Gly Ile Ile
        35                  40                  45              
Cys Thr Ile Gly Pro Ala Ser Arg Ser Val Glu Thr Leu Lys Glu Met
    50                  55                  60                  
Ile Lys Ser Gly Met Asn Val Ala Arg Leu Asn Phe Ser His Gly Thr
65                  70                  75                  80  
His Glu Tyr His Ala Glu Thr Ile Lys Asn Val Arg Thr Ala Thr Glu
                85                  90                  95      
Ser Phe Ala Ser Asp Pro Ile Leu Tyr Arg Pro Val Ala Val Ala Leu
            100                 105                 110         
Asp Thr Lys Gly Pro Glu Ile Arg Thr Gly Leu Ile Lys Gly Ser Gly
        115                 120                 125             
Thr Ala Glu Val Glu Leu Lys Lys Gly Ala Thr Leu Lys Ile Thr Leu
    130                 135                 140                 
Asp Asn Ala Tyr Met Glu Lys Cys Asp Glu Asn Ile Leu Trp Leu Asp
145                 150                 155                 160 
Tyr Lys Asn Ile Cys Lys Val Val Glu Val Gly Ser Lys Ile Tyr Val
                165                 170                 175     
Asp Asp Gly Leu Ile Ser Leu Gln Val Lys Gln Lys Gly Ala Asp Phe
            180                 185                 190         
Leu Val Thr Glu Val Glu Asn Gly Gly Ser Leu Gly Ser Lys Lys Gly
        195                 200                 205             
Val Asn Leu Pro Gly Ala Ala Val Asp Leu Pro Ala Val Ser Glu Lys
    210                 215                 220                 
Asp Ile Gln Asp Leu Lys Phe Gly Val Glu Gln Asp Val Asp Met Val
225                 230                 235                 240 
Phe Ala Ser Phe Ile Arg Lys Ala Ser Asp Val His Glu Val Arg Lys
                245                 250                 255     
Val Leu Gly Glu Lys Gly Lys Asn Ile Lys Ile Ile Ser Lys Ile Glu
            260                 265                 270         
Asn His Glu Gly Val Arg Arg Phe Asp Glu Ile Leu Glu Ala Ser Asp
        275                 280                 285             
Gly Ile Met Val Ala Arg Gly Asp Leu Gly Ile Glu Ile Pro Ala Glu
    290                 295                 300                 
Lys Val Phe Leu Ala Gln Lys Met Met Ile Gly Arg Cys Asn Arg Ala
305                 310                 315                 320 
Gly Lys Pro Val Ile Cys Ala Thr Gln Met Leu Glu Ser Met Ile Lys
                325                 330                 335     
Lys Pro Pro Pro Thr Arg Ala Glu Gly Ser Asp Val Ala Asn Ala Val
            340                 345                 350         
Leu Asp Gly Ala Asp Cys Ile Met Leu Ser Gly Glu Thr Ala Lys Gly
        355                 360                 365             
Asp Tyr Pro Leu Glu Ala Val Arg Met Gln His Leu Ile Ala Arg Glu
    370                 375                 380                 
Ala Glu Ala Ala Met Phe His Arg Lys Leu Phe Glu Glu Leu Val Arg
385                 390                 395                 400 
Ala Ser Ser His Ser Thr Asp Leu Met Glu Ala Met Ala Met Gly Ser
                405                 410                 415     
Val Glu Ala Ser Tyr Lys Cys Leu Ala Ala Ala Leu Ile Val Leu Thr
            420                 425                 430         
Glu Ser Gly Arg Ser Ala His Gln Val Ala Arg Tyr Arg Pro Arg Ala
        435                 440                 445             
Pro Ile Ile Ala Val Thr Arg Asn Pro Gln Thr Ala Arg Gln Ala His
    450                 455                 460                 
Leu Tyr Arg Gly Ile Phe Pro Val Leu Cys Lys Asp Pro Val Gln Glu
465                 470                 475                 480 
Ala Trp Ala Glu Asp Val Asp Leu Arg Val Asn Phe Ala Met Asn Val
                485                 490                 495     
Gly Lys Ala Arg Gly Phe Phe Lys Lys Gly Asp Val Val Ile Val Leu
            500                 505                 510         
Thr Gly Trp Arg Pro Gly Ser Gly Phe Thr Asn Thr Met Arg Val Val
        515                 520                 525             
Pro Val Pro
    530     


<210> 250
<211> 659
<212> PRT
<213> Homo sapiens

<400> 250
Met Asp Val Leu Val Ser Glu Cys Ser Ala Arg Leu Leu Gln Gln Glu
 1               5                  10                  15      
Glu Glu Ile Lys Ser Leu Thr Ala Glu Ile Asp Arg Leu Lys Asn Cys
            20                  25                  30          
Gly Cys Leu Gly Ala Ser Ser Asn Leu Glu Gln Leu Gln Glu Glu Asn
        35                  40                  45              
Leu Lys Leu Lys Tyr Arg Leu Asn Ile Leu Arg Lys Ser Leu Gln Ala
    50                  55                  60                  
Glu Arg Asn Lys Pro Thr Lys Asn Met Ile Asn Ile Ile Ser Arg Leu
65                  70                  75                  80  
Gln Glu Val Phe Gly His Ala Ile Lys Ala Ala Tyr Pro Asp Leu Glu
                85                  90                  95      
Asn Pro Pro Leu Leu Val Thr Pro Ser Gln Gln Ala Lys Phe Gly Asp
            100                 105                 110         
Tyr Gln Cys Asn Ser Ala Met Gly Ile Ser Gln Met Leu Lys Thr Lys
        115                 120                 125             
Glu Pro Glu Val Asn Pro Gly Glu Phe Ala Glu Asn Ile Thr Lys His
    130                 135                 140                 
Leu Pro Ala Met Asp Val Leu Lys Arg Val Glu Phe Ala Gly Pro Gly
145                 150                 155                 160 
Phe Ile Asn Gly His Leu Arg Lys Asp Phe Val Ser Glu Gln Leu Thr
                165                 170                 175     
Ser Leu Leu Val Asn Gly Val Gln Leu Pro Ala Leu Gly Glu Asn Lys
            180                 185                 190         
Lys Val Ile Val Asp Phe Ser Ser Pro Asn Ile Ala Lys Glu Met His
        195                 200                 205             
Val Gly His Leu Arg Ser Thr Ile Ile Gly Glu Ser Ile Ser Arg Leu
    210                 215                 220                 
Phe Glu Phe Ala Gly Tyr Asp Val Leu Arg Leu Asn His Val Gly Asp
225                 230                 235                 240 
Trp Gly Thr Gln Phe Gly Met Leu Ile Ala His Leu Gln Asp Lys Phe
                245                 250                 255     
Pro Asp Tyr Leu Thr Val Ser Pro Pro Ile Gly Asp Leu Gln Val Phe
            260                 265                 270         
Tyr Lys Glu Ser Lys Lys Arg Phe Asp Thr Glu Glu Glu Phe Lys Lys
        275                 280                 285             
Arg Ala Tyr Gln Cys Val Val Leu Leu Gln Gly Lys Asn Pro Asp Ile
    290                 295                 300                 
Thr Lys Ala Tyr Leu Leu Met Ser Asp Val Ser Arg Gln Glu Leu Asn
305                 310                 315                 320 
Lys Ile Tyr Asp Ala Leu Asp Val Ser Leu Ile Glu Arg Gly Glu Ser
                325                 330                 335     
Phe Tyr Gln Asp Arg Met Asn Asp Ile Val Lys Glu Phe Glu Asp Arg
            340                 345                 350         
Gly Phe Val Gln Val Asp Asp Gly Arg Lys Ile Val Phe Val Pro Gly
        355                 360                 365             
Cys Ser Ile Pro Leu Thr Ile Val Lys Ser Asp Gly Gly Tyr Thr Tyr
    370                 375                 380                 
Asp Thr Ser Asp Leu Ala Ala Ile Lys Gln Arg Leu Phe Glu Glu Lys
385                 390                 395                 400 
Ala Asp Met Ile Ile Tyr Val Val Asp Asn Gly Gln Ser Val His Phe
                405                 410                 415     
Gln Thr Ile Phe Ala Ala Ala Gln Met Ile Gly Trp Tyr Asp Pro Lys
            420                 425                 430         
Val Thr Arg Val Phe His Ala Gly Phe Gly Val Val Leu Gly Glu Asp
        435                 440                 445             
Lys Lys Lys Phe Lys Thr Arg Ser Gly Glu Thr Val Arg Leu Met Asp
    450                 455                 460                 
Leu Leu Gly Glu Gly Leu Lys Arg Ser Met Asp Lys Leu Lys Glu Lys
465                 470                 475                 480 
Glu Arg Asp Lys Val Leu Thr Ala Glu Glu Leu Asn Ala Ala Gln Thr
                485                 490                 495     
Ser Val Ala Tyr Gly Cys Ile Lys Tyr Ala Asp Leu Ser His Asn Arg
            500                 505                 510         
Leu Asn Asp Tyr Ile Phe Ser Phe Asp Lys Met Leu Asp Asp Arg Gly
        515                 520                 525             
Asn Thr Ala Ala Tyr Leu Leu Tyr Ala Phe Thr Arg Ile Arg Ser Ile
    530                 535                 540                 
Ala Arg Leu Ala Asn Ile Asp Glu Glu Met Leu Gln Lys Ala Ala Arg
545                 550                 555                 560 
Glu Thr Lys Ile Leu Leu Val His Glu Lys Glu Trp Lys Leu Gly Arg
                565                 570                 575     
Cys Ile Leu Arg Phe Pro Glu Ile Leu Gln Lys Ile Leu Asp Asp Leu
            580                 585                 590         
Phe Leu His Thr Leu Cys Asp Tyr Ile Tyr Glu Leu Ala Thr Ala Phe
        595                 600                 605             
Thr Glu Phe Tyr Asp Ser Cys Tyr Cys Val Glu Lys Asp Arg Gln Thr
    610                 615                 620                 
Gly Lys Ile Leu Lys Val Asn Met Trp Arg Ile Leu Cys Glu Thr Val
625                 630                 635                 640 
Ala Ala Val Met Ala Lys Gly Phe Asp Thr Leu Gly Ile Lys Pro Gly
                645                 650                 655     
Pro Arg Val
            


<210> 251
<211> 59
<212> PRT
<213> Homo sapiens

<400> 251
Met Ser Glu Thr Ala Pro Ala Glu Thr Ala Thr Pro Ala Pro Val Glu
 1               5                  10                  15      
Lys Ser Pro Ala Lys Lys Lys Ala Thr Lys Lys Ala Ala Gly Ala Gly
            20                  25                  30          
Ala Ala Lys Arg Ile Ala Ala Gly Pro Pro Val Ser Glu Leu Ile Thr
        35                  40                  45              
Lys Ala Val Pro Ala Ser Lys Glu Arg Asn Ala
    50                  55                  


<210> 252
<211> 342
<212> PRT
<213> Homo sapiens

<400> 252
Ile Gly Lys Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu
 1               5                  10                  15      
Ala Asp Gln Cys Thr Arg Leu Gln Gly Phe Leu Val Phe His Ser Phe
            20                  25                  30          
Gly Gly Gly Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu
        35                  40                  45              
Ser Val Asp Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro
    50                  55                  60                  
Ala Pro Gln Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu
65                  70                  75                  80  
Thr Thr His Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp
                85                  90                  95      
Asn Glu Ala Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg
            100                 105                 110         
Pro Thr Tyr Thr Asn Leu Asn Arg Leu Ile Gly Gln Ile Val Ser Ser
        115                 120                 125             
Ile Thr Ala Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr
    130                 135                 140                 
Glu Phe Gln Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu
145                 150                 155                 160 
Ala Thr Tyr Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln
                165                 170                 175     
Leu Ser Val Ala Asp Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln
            180                 185                 190         
Met Val Lys Cys Asp Pro Gly His Gly Lys Tyr Met Ala Cys Cys Leu
        195                 200                 205             
Leu Tyr Arg Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala
    210                 215                 220                 
Thr Ile Lys Thr Lys Arg Thr Ile Gln Phe Val Asp Trp Cys Pro Thr
225                 230                 235                 240 
Gly Phe Lys Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly
                245                 250                 255     
Gly Asp Leu Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr
            260                 265                 270         
Thr Ala Ile Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu
        275                 280                 285             
Met Tyr Ala Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met
    290                 295                 300                 
Glu Glu Gly Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu
305                 310                 315                 320 
Lys Asp Tyr Glu Glu Val Gly Val Asp Ser Val Glu Gly Glu Gly Glu
                325                 330                 335     
Glu Glu Gly Glu Glu Tyr
            340         


<210> 253
<211> 267
<212> PRT
<213> Homo sapiens

<400> 253
Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser
 1               5                  10                  15      
Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp
            20                  25                  30          
Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp
        35                  40                  45              
Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys
    50                  55                  60                  
Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr
65                  70                  75                  80  
Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp
                85                  90                  95      
Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys
            100                 105                 110         
Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe
        115                 120                 125             
Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Asp
    130                 135                 140                 
Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu
145                 150                 155                 160 
Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala
                165                 170                 175     
Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp
            180                 185                 190         
Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn
        195                 200                 205             
Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu
    210                 215                 220                 
Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln
225                 230                 235                 240 
Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala
                245                 250                 255     
Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln
            260                 265         


<210> 254
<211> 3225
<212> PRT
<213> Homo sapiens

<400> 254
Met Glu Phe Asn Asn Thr Thr Gln Glu Asp Val Gln Glu Arg Leu Ala
 1               5                  10                  15      
Tyr Ala Glu Gln Leu Val Val Glu Leu Lys Asp Ile Ile Arg Gln Lys
            20                  25                  30          
Asp Val Gln Leu Gln Gln Lys Asp Glu Ala Leu Gln Glu Glu Arg Lys
        35                  40                  45              
Ala Ala Asp Asn Lys Ile Lys Lys Leu Lys Leu His Ala Lys Ala Lys
    50                  55                  60                  
Leu Thr Ser Leu Asn Lys Tyr Ile Glu Glu Met Lys Ala Gln Gly Gly
65                  70                  75                  80  
Thr Val Leu Pro Thr Glu Pro Gln Ser Glu Glu Gln Leu Ser Lys His
                85                  90                  95      
Asp Lys Ser Ser Thr Glu Glu Glu Met Glu Ile Glu Lys Ile Lys His
            100                 105                 110         
Lys Leu Gln Glu Lys Glu Glu Leu Ile Ser Thr Leu Gln Ala Gln Leu
        115                 120                 125             
Thr Gln Ala Gln Ala Glu Gln Pro Ala Gln Ser Ser Thr Glu Met Glu
    130                 135                 140                 
Glu Phe Val Met Met Lys Gln Gln Leu Gln Glu Lys Glu Glu Phe Ile
145                 150                 155                 160 
Ser Thr Leu Gln Ala Gln Leu Ser Gln Thr Gln Ala Glu Gln Ala Ala
                165                 170                 175     
Gln Leu Ser Ser Met Gln Gln Val Val Arg Glu Lys Asp Ala Arg Phe
            180                 185                 190         
Glu Thr Gln Val Arg Leu His Glu Asp Glu Leu Leu Gln Leu Val Thr
        195                 200                 205             
Gln Ala Asp Val Glu Thr Glu Met Gln Gln Lys Leu Arg Val Leu Gln
    210                 215                 220                 
Arg Lys Leu Glu Glu His Glu Glu Ser Leu Val Gly Arg Ala Gln Val
225                 230                 235                 240 
Val Asp Leu Leu Gln Gln Glu Leu Thr Ala Ala Glu Gln Arg Asn Gln
                245                 250                 255     
Ile Leu Ser Gln Gln Leu Gln Gln Met Glu Ala Glu His Asn Thr Leu
            260                 265                 270         
Arg Asn Thr Val Glu Thr Glu Arg Glu Glu Ser Lys Ile Leu Leu Glu
        275                 280                 285             
Lys Met Glu Leu Glu Val Ala Glu Arg Lys Leu Ser Phe His Asn Leu
    290                 295                 300                 
Gln Glu Glu Met His His Leu Leu Glu Gln Phe Glu Gln Ala Gly Gln
305                 310                 315                 320 
Ala Gln Ala Glu Leu Glu Ser Arg Tyr Ser Ala Leu Glu Gln Lys His
                325                 330                 335     
Lys Ala Glu Met Glu Glu Lys Thr Ser His Ile Leu Ser Leu Gln Lys
            340                 345                 350         
Thr Gly Gln Glu Leu Gln Ser Ala Cys Asp Ala Leu Lys Asp Gln Asn
        355                 360                 365             
Ser Lys Leu Leu Gln Asp Lys Asn Glu Gln Ala Val Gln Ser Ala Gln
    370                 375                 380                 
Thr Ile Gln Gln Leu Glu Asp Gln Leu Gln Gln Lys Ser Lys Glu Ile
385                 390                 395                 400 
Ser Gln Phe Leu Asn Arg Leu Pro Leu Gln Gln His Glu Thr Ala Ser
                405                 410                 415     
Gln Thr Ser Phe Pro Asp Val Tyr Asn Glu Gly Thr Gln Ala Val Thr
            420                 425                 430         
Glu Glu Asn Ile Ala Ser Leu Gln Lys Arg Val Val Glu Leu Glu Asn
        435                 440                 445             
Glu Lys Gly Ala Leu Leu Leu Ser Ser Ile Glu Leu Glu Glu Leu Lys
    450                 455                 460                 
Ala Glu Asn Glu Lys Leu Ser Ser Gln Ile Thr Leu Leu Glu Ala Gln
465                 470                 475                 480 
Asn Arg Thr Gly Glu Ala Asp Arg Glu Val Ser Glu Ile Ser Ile Val
                485                 490                 495     
Asp Ile Ala Asn Lys Arg Ser Ser Ser Ala Glu Glu Ser Gly Gln Asp
            500                 505                 510         
Val Leu Glu Asn Thr Phe Ser Gln Lys His Lys Glu Leu Ser Val Leu
        515                 520                 525             
Leu Leu Glu Met Lys Glu Ala Gln Glu Glu Ile Ala Phe Leu Lys Leu
    530                 535                 540                 
Gln Leu Gln Gly Lys Arg Ala Glu Glu Ala Asp His Glu Val Leu Asp
545                 550                 555                 560 
Gln Lys Glu Met Lys Gln Met Glu Gly Glu Gly Ile Ala Pro Ile Lys
                565                 570                 575     
Met Lys Val Phe Leu Glu Asp Thr Gly Gln Asp Phe Pro Leu Met Pro
            580                 585                 590         
Asn Glu Glu Ser Ser Leu Pro Ala Val Glu Lys Glu Gln Ala Ser Thr
        595                 600                 605             
Glu His Gln Ser Arg Thr Ser Glu Glu Ile Ser Leu Asn Asp Ala Gly
    610                 615                 620                 
Val Glu Leu Lys Ser Thr Lys Gln Asp Gly Asp Lys Ser Leu Ser Ala
625                 630                 635                 640 
Val Pro Asp Ile Gly Gln Cys His Gln Asp Glu Leu Glu Arg Leu Lys
                645                 650                 655     
Ser Gln Ile Leu Glu Leu Glu Leu Asn Phe His Lys Ala Gln Glu Ile
            660                 665                 670         
Tyr Glu Lys Asn Leu Asp Glu Lys Ala Lys Glu Ile Ser Asn Leu Asn
        675                 680                 685             
Gln Leu Ile Glu Glu Phe Lys Lys Asn Ala Asp Asn Asn Ser Ser Ala
    690                 695                 700                 
Phe Thr Ala Leu Ser Glu Glu Arg Asp Gln Leu Leu Ser Gln Val Lys
705                 710                 715                 720 
Glu Leu Ser Met Val Thr Glu Leu Arg Ala Gln Val Lys Gln Leu Glu
                725                 730                 735     
Met Asn Leu Ala Glu Ala Glu Arg Gln Arg Arg Leu Asp Tyr Glu Ser
            740                 745                 750         
Gln Thr Ala His Asp Asn Leu Leu Thr Glu Gln Ile His Ser Leu Ser
        755                 760                 765             
Ile Glu Ala Lys Ser Lys Asp Val Lys Ile Glu Val Leu Gln Asn Glu
    770                 775                 780                 
Leu Asp Asp Val Gln Leu Gln Phe Ser Glu Gln Ser Thr Leu Ile Arg
785                 790                 795                 800 
Ser Leu Gln Ser Gln Leu Gln Asn Lys Glu Ser Glu Val Leu Glu Gly
                805                 810                 815     
Ala Glu Arg Val Arg His Ile Ser Ser Lys Val Glu Glu Leu Ser Gln
            820                 825                 830         
Ala Leu Ser Gln Lys Glu Leu Glu Ile Thr Lys Met Asp Gln Leu Leu
        835                 840                 845             
Leu Glu Lys Lys Arg Asp Val Glu Thr Leu Gln Gln Thr Ile Glu Glu
    850                 855                 860                 
Lys Asp Gln Gln Val Thr Glu Ile Ser Phe Ser Met Thr Glu Lys Met
865                 870                 875                 880 
Val Gln Leu Asn Glu Glu Lys Phe Ser Leu Gly Val Glu Ile Lys Thr
                885                 890                 895     
Leu Lys Glu Gln Leu Asn Leu Leu Ser Arg Ala Glu Glu Ala Lys Lys
            900                 905                 910         
Glu Gln Val Glu Glu Asp Asn Glu Val Ser Ser Gly Leu Lys Gln Asn
        915                 920                 925             
Tyr Asp Glu Met Ser Pro Ala Gly Gln Ile Ser Lys Glu Glu Leu Gln
    930                 935                 940                 
His Glu Phe Asp Leu Leu Lys Lys Glu Asn Glu Gln Arg Lys Arg Lys
945                 950                 955                 960 
Leu Gln Ala Ala Leu Ile Asn Arg Lys Glu Leu Leu Gln Arg Val Ser
                965                 970                 975     
Arg Leu Glu Glu Glu Leu Ala Asn Leu Lys Asp Glu Ser Lys Lys Glu
            980                 985                 990         
Ile Pro Leu Ser Glu Thr Glu Arg Gly Glu Val Glu Glu Asp Lys Glu
        995                 1000                1005            
Asn Lys Glu Tyr Ser Glu Lys Cys Val Thr Ser Lys Cys Gln Glu Ile
    1010                1015                1020                
Glu Ile Tyr Leu Lys Gln Thr Ile Ser Glu Lys Glu Val Glu Leu Gln
1025                1030                1035                1040
His Ile Arg Lys Asp Leu Glu Glu Lys Leu Ala Ala Glu Glu Gln Phe
                1045                1050                1055    
Gln Ala Leu Val Lys Gln Met Asn Gln Thr Leu Gln Asp Lys Thr Asn
            1060                1065                1070        
Gln Ile Asp Leu Leu Gln Ala Glu Ile Ser Glu Asn Gln Ala Ile Ile
        1075                1080                1085            
Gln Lys Leu Ile Thr Ser Asn Thr Asp Ala Ser Asp Gly Asp Ser Val
    1090                1095                1100                
Ala Leu Val Lys Glu Thr Val Val Ile Ser Pro Pro Cys Thr Gly Ser
1105                1110                1115                1120
Ser Glu His Trp Lys Pro Glu Leu Glu Glu Lys Ile Leu Ala Leu Glu
                1125                1130                1135    
Lys Glu Lys Glu Gln Leu Gln Lys Lys Leu Gln Glu Ala Leu Thr Ser
            1140                1145                1150        
Arg Lys Ala Ile Leu Lys Lys Ala Gln Glu Lys Glu Arg His Leu Arg
        1155                1160                1165            
Glu Glu Leu Lys Gln Gln Lys Asp Asp Tyr Asn Arg Leu Gln Glu Gln
    1170                1175                1180                
Phe Asp Glu Gln Ser Lys Glu Asn Glu Asn Ile Gly Asp Gln Leu Arg
1185                1190                1195                1200
Gln Leu Gln Ile Gln Val Arg Glu Ser Ile Asp Gly Lys Leu Pro Ser
                1205                1210                1215    
Thr Asp Gln Gln Glu Ser Cys Ser Ser Thr Pro Gly Leu Glu Glu Pro
            1220                1225                1230        
Leu Phe Lys Ala Thr Glu Gln His His Thr Gln Pro Val Leu Glu Ser
        1235                1240                1245            
Asn Leu Cys Pro Asp Trp Pro Ser His Ser Glu Asp Ala Ser Ala Leu
    1250                1255                1260                
Gln Gly Gly Thr Ser Val Ala Gln Ile Lys Ala Gln Leu Lys Glu Ile
1265                1270                1275                1280
Glu Ala Glu Lys Val Glu Leu Glu Leu Lys Val Ser Ser Thr Thr Ser
                1285                1290                1295    
Glu Leu Thr Lys Lys Ser Glu Glu Val Phe Gln Leu Gln Glu Gln Ile
            1300                1305                1310        
Asn Lys Gln Gly Leu Glu Ile Glu Ser Leu Lys Thr Val Ser His Glu
        1315                1320                1325            
Ala Glu Val His Ala Glu Ser Leu Gln Gln Lys Leu Glu Ser Ser Gln
    1330                1335                1340                
Leu Gln Ile Ala Gly Leu Glu His Leu Arg Glu Leu Gln Pro Lys Leu
1345                1350                1355                1360
Asp Glu Leu Gln Lys Leu Ile Ser Lys Lys Glu Glu Asp Val Ser Tyr
                1365                1370                1375    
Leu Ser Gly Gln Leu Ser Glu Lys Glu Ala Ala Leu Thr Lys Ile Gln
            1380                1385                1390        
Thr Glu Ile Ile Glu Gln Glu Asp Leu Ile Lys Ala Leu His Thr Gln
        1395                1400                1405            
Leu Glu Met Gln Ala Lys Glu His Asp Glu Arg Ile Lys Gln Leu Gln
    1410                1415                1420                
Val Glu Leu Cys Glu Met Lys Gln Lys Pro Glu Glu Ile Gly Glu Glu
1425                1430                1435                1440
Ser Arg Ala Lys Gln Gln Ile Gln Arg Lys Leu Gln Ala Ala Leu Ile
                1445                1450                1455    
Ser Arg Lys Glu Ala Leu Lys Glu Asn Lys Ser Leu Gln Glu Glu Leu
            1460                1465                1470        
Ser Leu Ala Arg Gly Thr Ile Glu Arg Leu Thr Lys Ser Leu Ala Asp
        1475                1480                1485            
Val Glu Ser Gln Val Ser Ala Gln Asn Lys Glu Lys Asp Thr Val Leu
    1490                1495                1500                
Gly Arg Leu Ala Leu Leu Gln Glu Glu Arg Asp Lys Leu Ile Thr Glu
1505                1510                1515                1520
Met Asp Arg Ser Leu Leu Glu Asn Gln Ser Leu Ser Ser Ser Cys Glu
                1525                1530                1535    
Ser Leu Lys Leu Ala Leu Glu Gly Leu Thr Glu Asp Lys Glu Lys Leu
            1540                1545                1550        
Val Lys Glu Ile Glu Ser Leu Lys Ser Ser Lys Ile Ala Glu Ser Thr
        1555                1560                1565            
Glu Trp Gln Glu Lys His Lys Glu Leu Gln Lys Glu Tyr Glu Ile Leu
    1570                1575                1580                
Leu Gln Ser Tyr Glu Asn Val Ser Asn Glu Ala Glu Arg Ile Gln His
1585                1590                1595                1600
Val Val Glu Ala Val Arg Gln Glu Lys Gln Glu Leu Tyr Gly Lys Leu
                1605                1610                1615    
Arg Ser Thr Glu Ala Asn Lys Lys Glu Thr Glu Lys Gln Leu Gln Glu
            1620                1625                1630        
Ala Glu Gln Glu Met Glu Glu Met Lys Glu Lys Met Arg Lys Phe Ala
        1635                1640                1645            
Lys Ser Lys Gln Gln Lys Ile Leu Glu Leu Glu Glu Glu Asn Asp Arg
    1650                1655                1660                
Leu Arg Ala Glu Val His Pro Ala Gly Asp Thr Ala Lys Glu Cys Met
1665                1670                1675                1680
Glu Thr Leu Leu Ser Ser Asn Ala Ser Met Lys Glu Glu Leu Glu Arg
                1685                1690                1695    
Val Lys Met Glu Tyr Glu Thr Leu Ser Lys Lys Phe Gln Ser Leu Met
            1700                1705                1710        
Ser Glu Lys Asp Ser Leu Ser Glu Glu Val Gln Asp Leu Lys His Gln
        1715                1720                1725            
Ile Glu Gly Asn Val Ser Lys Gln Ala Asn Leu Glu Ala Thr Glu Lys
    1730                1735                1740                
His Asp Asn Gln Thr Asn Val Thr Glu Glu Gly Thr Gln Ser Ile Pro
1745                1750                1755                1760
Gly Glu Thr Glu Glu Gln Asp Ser Leu Ser Met Ser Thr Arg Pro Thr
                1765                1770                1775    
Cys Ser Glu Ser Val Pro Ser Ala Lys Ser Ala Asn Pro Ala Val Ser
            1780                1785                1790        
Lys Asp Phe Ser Ser His Asp Glu Ile Asn Asn Tyr Leu Gln Gln Ile
        1795                1800                1805            
Asp Gln Leu Lys Glu Arg Ile Ala Gly Leu Glu Glu Glu Lys Gln Lys
    1810                1815                1820                
Asn Lys Glu Phe Ser Gln Thr Leu Glu Asn Glu Lys Asn Thr Leu Leu
1825                1830                1835                1840
Ser Gln Ile Ser Thr Lys Asp Gly Glu Leu Lys Met Leu Gln Glu Glu
                1845                1850                1855    
Val Thr Lys Met Asn Leu Leu Asn Gln Gln Ile Gln Glu Glu Leu Ser
            1860                1865                1870        
Arg Val Thr Lys Leu Lys Glu Thr Ala Glu Glu Glu Lys Asp Asp Leu
        1875                1880                1885            
Glu Glu Arg Leu Met Asn Gln Leu Ala Glu Leu Asn Gly Ser Ile Gly
    1890                1895                1900                
Asn Tyr Cys Gln Asp Val Thr Asp Ala Gln Ile Lys Asn Glu Leu Leu
1905                1910                1915                1920
Glu Ser Glu Met Lys Asn Leu Lys Lys Cys Val Ser Glu Leu Glu Glu
                1925                1930                1935    
Glu Lys Gln Gln Leu Val Lys Glu Lys Thr Lys Val Glu Ser Glu Ile
            1940                1945                1950        
Arg Lys Glu Tyr Leu Glu Lys Ile Gln Gly Ala Gln Lys Glu Pro Gly
        1955                1960                1965            
Asn Lys Ser His Ala Lys Glu Leu Gln Glu Leu Leu Lys Glu Lys Gln
    1970                1975                1980                
Gln Glu Val Lys Gln Leu Gln Lys Asp Cys Ile Arg Tyr Gln Glu Lys
1985                1990                1995                2000
Ile Ser Ala Leu Glu Arg Thr Val Lys Ala Leu Glu Phe Val Gln Thr
                2005                2010                2015    
Glu Ser Gln Lys Asp Leu Glu Ile Thr Lys Glu Asn Leu Ala Gln Ala
            2020                2025                2030        
Val Glu His Arg Lys Lys Ala Gln Ala Glu Leu Ala Ser Phe Lys Val
        2035                2040                2045            
Leu Leu Asp Asp Thr Gln Ser Glu Ala Ala Arg Val Leu Ala Asp Asn
    2050                2055                2060                
Leu Lys Leu Lys Lys Glu Leu Gln Ser Asn Lys Glu Ser Val Lys Ser
2065                2070                2075                2080
Gln Met Lys Gln Lys Asp Glu Asp Leu Glu Arg Arg Leu Glu Gln Ala
                2085                2090                2095    
Glu Glu Lys His Leu Lys Glu Lys Lys Asn Met Gln Glu Lys Leu Asp
            2100                2105                2110        
Ala Leu Arg Arg Glu Lys Val His Leu Glu Glu Thr Ile Gly Glu Ile
        2115                2120                2125            
Gln Val Thr Leu Asn Lys Lys Asp Lys Glu Val Gln Gln Leu Gln Glu
    2130                2135                2140                
Asn Leu Asp Ser Thr Val Thr Gln Leu Ala Ala Phe Thr Lys Ser Met
2145                2150                2155                2160
Ser Ser Leu Gln Asp Asp Arg Asp Arg Val Ile Asp Glu Ala Lys Lys
                2165                2170                2175    
Trp Glu Arg Lys Phe Ser Asp Ala Ile Gln Ser Lys Glu Glu Glu Ile
            2180                2185                2190        
Arg Leu Lys Glu Asp Asn Cys Ser Val Leu Lys Asp Gln Leu Arg Gln
        2195                2200                2205            
Met Ser Ile His Met Glu Glu Leu Lys Ile Asn Ile Ser Arg Leu Glu
    2210                2215                2220                
His Asp Lys Gln Ile Trp Glu Ser Lys Ala Gln Thr Glu Val Gln Leu
2225                2230                2235                2240
Gln Gln Lys Val Cys Asp Thr Leu Gln Gly Glu Asn Lys Glu Leu Leu
                2245                2250                2255    
Ser Gln Leu Glu Glu Thr Arg His Leu Tyr His Ser Ser Gln Asn Glu
            2260                2265                2270        
Leu Ala Lys Leu Glu Ser Glu Leu Lys Ser Leu Lys Asp Gln Leu Thr
        2275                2280                2285            
Asp Leu Ser Asn Ser Leu Glu Lys Cys Lys Glu Gln Lys Gly Asn Leu
    2290                2295                2300                
Glu Gly Ile Ile Arg Gln Gln Glu Ala Asp Ile Gln Asn Ser Lys Phe
2305                2310                2315                2320
Ser Tyr Glu Gln Leu Glu Thr Asp Leu Gln Ala Ser Arg Glu Leu Thr
                2325                2330                2335    
Ser Arg Leu His Glu Glu Ile Asn Met Lys Glu Gln Lys Ile Ile Ser
            2340                2345                2350        
Leu Leu Ser Gly Lys Glu Glu Ala Ile Gln Val Ala Ile Ala Glu Leu
        2355                2360                2365            
Arg Gln Gln His Asp Lys Glu Ile Lys Glu Leu Glu Asn Leu Leu Ser
    2370                2375                2380                
Gln Glu Glu Glu Glu Asn Ile Val Leu Glu Glu Glu Asn Lys Lys Ala
2385                2390                2395                2400
Val Asp Lys Thr Asn Gln Leu Met Glu Thr Leu Lys Thr Ile Lys Lys
                2405                2410                2415    
Glu Asn Ile Gln Gln Lys Ala Gln Leu Asp Ser Phe Val Lys Ser Met
            2420                2425                2430        
Ser Ser Leu Gln Asn Asp Arg Asp Arg Ile Val Gly Asp Tyr Gln Gln
        2435                2440                2445            
Leu Glu Glu Arg His Leu Ser Ile Ile Leu Glu Lys Asp Gln Leu Ile
    2450                2455                2460                
Gln Glu Ala Ala Ala Glu Asn Asn Lys Leu Lys Glu Glu Ile Arg Gly
2465                2470                2475                2480
Leu Arg Ser His Met Asp Asp Leu Asn Ser Glu Asn Ala Lys Leu Asp
                2485                2490                2495    
Ala Glu Leu Ile Gln Tyr Arg Glu Asp Leu Asn Gln Val Ile Thr Ile
            2500                2505                2510        
Lys Asp Ser Gln Gln Lys Gln Leu Leu Glu Val Gln Leu Gln Gln Asn
        2515                2520                2525            
Lys Glu Leu Glu Asn Lys Tyr Ala Lys Leu Glu Glu Lys Leu Lys Glu
    2530                2535                2540                
Ser Glu Glu Ala Asn Glu Asp Leu Arg Arg Ser Phe Asn Ala Leu Gln
2545                2550                2555                2560
Glu Glu Lys Gln Asp Leu Ser Lys Glu Ile Glu Ser Leu Lys Val Ser
                2565                2570                2575    
Ile Ser Gln Leu Thr Arg Gln Val Thr Ala Leu Gln Glu Glu Gly Thr
            2580                2585                2590        
Leu Gly Leu Tyr His Ala Gln Leu Lys Val Lys Glu Glu Glu Val His
        2595                2600                2605            
Arg Leu Ser Ala Leu Phe Ser Ser Ser Gln Lys Arg Ile Ala Glu Leu
    2610                2615                2620                
Glu Glu Glu Leu Val Cys Val Gln Lys Glu Ala Ala Lys Lys Val Gly
2625                2630                2635                2640
Glu Ile Glu Asp Lys Leu Lys Lys Glu Leu Lys His Leu His His Asp
                2645                2650                2655    
Ala Gly Ile Met Arg Asn Glu Thr Glu Thr Ala Glu Glu Arg Val Ala
            2660                2665                2670        
Glu Leu Ala Arg Asp Leu Val Glu Met Glu Gln Lys Leu Leu Met Val
        2675                2680                2685            
Thr Lys Glu Asn Lys Gly Leu Thr Ala Gln Ile Gln Ser Phe Gly Arg
    2690                2695                2700                
Ser Met Ser Ser Leu Gln Asn Ser Arg Asp His Ala Asn Glu Glu Leu
2705                2710                2715                2720
Asp Glu Leu Lys Arg Lys Tyr Asp Ala Ser Leu Lys Glu Leu Ala Gln
                2725                2730                2735    
Leu Lys Glu Gln Gly Leu Leu Asn Arg Glu Arg Asp Ala Leu Leu Ser
            2740                2745                2750        
Glu Thr Ala Phe Ser Met Asn Ser Thr Glu Glu Asn Ser Leu Ser His
        2755                2760                2765            
Leu Glu Lys Leu Asn Gln Gln Leu Leu Ser Lys Asp Glu Gln Leu Leu
    2770                2775                2780                
His Leu Ser Ser Gln Leu Glu Asp Ser Tyr Asn Gln Val Gln Ser Phe
2785                2790                2795                2800
Ser Lys Ala Met Ala Ser Leu Gln Asn Glu Arg Asp His Leu Trp Asn
                2805                2810                2815    
Glu Leu Glu Lys Phe Arg Lys Ser Glu Glu Gly Lys Gln Arg Ser Ala
            2820                2825                2830        
Ala Gln Pro Ser Thr Ser Pro Ala Glu Val Gln Ser Leu Lys Lys Ala
        2835                2840                2845            
Met Ser Ser Leu Gln Asn Asp Arg Asp Arg Leu Leu Lys Glu Leu Lys
    2850                2855                2860                
Asn Leu Gln Gln Gln Tyr Leu Gln Ile Asn Gln Glu Ile Thr Glu Leu
2865                2870                2875                2880
His Pro Leu Lys Ala Gln Leu Gln Glu Tyr Gln Asp Lys Thr Lys Ala
                2885                2890                2895    
Phe Gln Ile Met Gln Glu Glu Leu Arg Gln Glu Asn Leu Ser Trp Gln
            2900                2905                2910        
His Glu Leu Asp Gln Leu Arg Met Glu Lys Ser Ser Trp Glu Ile His
        2915                2920                2925            
Glu Arg Arg Met Lys Glu Gln Tyr Leu Met Ala Ile Ser Asp Lys Asp
    2930                2935                2940                
Gln Gln Leu Ser His Leu Gln Asn Leu Ile Arg Glu Leu Arg Ser Ser
2945                2950                2955                2960
Ser Ser Gln Thr Gln Pro Leu Lys Val Gln Tyr Gln Arg Gln Ala Ser
                2965                2970                2975    
Pro Glu Thr Ser Ala Ser Pro Asp Gly Ser Gln Asn Leu Val Tyr Glu
            2980                2985                2990        
Thr Glu Leu Leu Arg Thr Gln Leu Asn Asp Ser Leu Lys Glu Ile His
        2995                3000                3005            
Gln Lys Glu Leu Arg Ile Gln Gln Leu Asn Ser Asn Phe Ser Gln Leu
    3010                3015                3020                
Leu Glu Glu Lys Asn Thr Leu Ser Ile Gln Leu Cys Asp Thr Ser Gln
3025                3030                3035                3040
Ser Leu Arg Glu Asn Gln Gln His Tyr Gly Asp Leu Leu Asn His Cys
                3045                3050                3055    
Ala Val Leu Glu Lys Gln Val Gln Glu Leu Gln Ala Gly Pro Leu Asn
            3060                3065                3070        
Ile Asp Val Ala Pro Gly Ala Pro Gln Glu Lys Asn Gly Val His Arg
        3075                3080                3085            
Lys Ser Asp Pro Glu Glu Leu Arg Glu Pro Gln Gln Ser Phe Ser Glu
    3090                3095                3100                
Ala Gln Gln Gln Leu Cys Asn Thr Arg Gln Glu Val Asn Glu Leu Arg
3105                3110                3115                3120
Lys Leu Leu Glu Glu Glu Arg Asp Gln Arg Val Ala Ala Glu Asn Ala
                3125                3130                3135    
Leu Ser Val Ala Glu Glu Gln Ile Arg Arg Leu Glu His Ser Glu Trp
            3140                3145                3150        
Asp Ser Ser Arg Thr Pro Ile Ile Gly Ser Cys Gly Thr Gln Glu Gln
        3155                3160                3165            
Ala Leu Leu Ile Asp Leu Thr Ser Asn Ser Cys Arg Arg Thr Arg Ser
    3170                3175                3180                
Gly Val Gly Trp Lys Arg Val Leu Arg Ser Leu Cys His Ser Arg Thr
3185                3190                3195                3200
Arg Val Pro Leu Leu Ala Ala Ile Tyr Phe Leu Met Ile His Val Leu
                3205                3210                3215    
Leu Ile Leu Cys Phe Thr Gly His Leu
            3220                3225


<210> 255
<211> 640
<212> PRT
<213> Homo sapiens

<400> 255
Met Ala Lys Ala Ala Ala Val Gly Ile Asp Leu Gly Thr Thr Tyr Ser
 1               5                  10                  15      
Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp
            20                  25                  30          
Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu
        35                  40                  45              
Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Leu Asn Pro Gln
    50                  55                  60                  
Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe Gly Asp
65                  70                  75                  80  
Pro Val Val Gln Ser Asp Met Lys His Trp Pro Phe Gln Val Ile Asn
                85                  90                  95      
Asp Gly Asp Lys Pro Lys Val Gln Val Ser Tyr Lys Gly Glu Thr Lys
            100                 105                 110         
Ala Phe Tyr Pro Glu Glu Ile Ser Ser Met Val Leu Thr Lys Met Lys
        115                 120                 125             
Glu Ile Ala Glu Ala Tyr Leu Gly Tyr Pro Val Thr Asn Ala Val Ile
    130                 135                 140                 
Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp
145                 150                 155                 160 
Ala Gly Val Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro
                165                 170                 175     
Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Arg Thr Gly Lys Gly Glu
            180                 185                 190         
Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser
        195                 200                 205             
Ile Leu Thr Ile Asp Asp Gly Ile Phe Glu Val Lys Ala Thr Ala Gly
    210                 215                 220                 
Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val Asn His
225                 230                 235                 240 
Phe Val Glu Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Gln Asn
                245                 250                 255     
Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg
            260                 265                 270         
Thr Leu Ser Ser Ser Thr Gln Ala Ser Leu Glu Ile Asp Ser Leu Phe
        275                 280                 285             
Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu
    290                 295                 300                 
Leu Cys Ser Asp Leu Phe Arg Ser Thr Leu Glu Pro Val Glu Lys Ala
305                 310                 315                 320 
Leu Arg Asp Ala Lys Leu Asp Lys Ala Gln Ile His Asp Leu Val Leu
                325                 330                 335     
Val Gly Gly Ser Thr Arg Ile Pro Lys Val Gln Lys Leu Leu Gln Asp
            340                 345                 350         
Phe Phe Asn Gly Arg Asp Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala
        355                 360                 365             
Val Gly Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Met Gly Asp Lys
    370                 375                 380                 
Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Ala Pro Leu Ser
385                 390                 395                 400 
Leu Gly Leu Glu Thr Ala Gly Gly Val Met Thr Ala Leu Ile Lys Arg
                405                 410                 415     
Asn Ser Thr Ile Pro Thr Lys Gln Thr Gln Ile Phe Thr Thr Tyr Ser
            420                 425                 430         
Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala
        435                 440                 445             
Met Thr Lys Asp Asn Asn Leu Leu Gly Arg Phe Glu Leu Ser Gly Ile
    450                 455                 460                 
Pro Pro Ala Pro Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile Asp
465                 470                 475                 480 
Ala Asn Gly Ile Leu Asn Val Thr Ala Thr Asp Lys Ser Thr Gly Lys
                485                 490                 495     
Ala Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys Glu
            500                 505                 510         
Glu Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu Asp
        515                 520                 525             
Glu Val Gln Arg Glu Arg Val Ser Ala Lys Asn Ala Leu Glu Ser Tyr
    530                 535                 540                 
Ala Phe Asn Met Lys Ser Ala Val Glu Asp Glu Gly Leu Lys Gly Lys
545                 550                 555                 560 
Ile Ser Glu Ala Asp Lys Lys Lys Val Leu Asp Lys Cys Gln Glu Val
                565                 570                 575     
Ile Ser Trp Leu Asp Ala Asn Thr Leu Ala Glu Lys Asp Glu Phe Glu
            580                 585                 590         
His Lys Arg Lys Glu Leu Glu Gln Val Cys Asn Pro Ile Ile Ser Gly
        595                 600                 605             
Leu Tyr Gln Gly Ala Gly Gly Pro Gly Pro Gly Gly Phe Gly Ala Gln
    610                 615                 620                 
Gly Pro Lys Gly Gly Ser Gly Ser Gly Pro Thr Ile Glu Glu Val Asp
625                 630                 635                 640 


<210> 256
<211> 452
<212> PRT
<213> Homo sapiens

<400> 256
Met Thr Thr Met Ala Ala Ala Thr Leu Leu Arg Ala Thr Pro His Phe
 1               5                  10                  15      
Ser Gly Leu Ala Ala Gly Arg Thr Phe Leu Leu Gln Gly Leu Leu Arg
            20                  25                  30          
Leu Leu Lys Ala Pro Ala Leu Pro Leu Leu Cys Arg Gly Leu Ala Val
        35                  40                  45              
Glu Ala Lys Lys Thr Tyr Val Arg Asp Lys Pro His Val Asn Val Gly
    50                  55                  60                  
Thr Ile Gly His Val Asp His Gly Lys Thr Thr Leu Thr Ala Ala Ile
65                  70                  75                  80  
Thr Lys Ile Leu Ala Glu Gly Gly Gly Ala Lys Phe Lys Lys Tyr Glu
                85                  90                  95      
Glu Ile Asp Asn Ala Pro Glu Glu Arg Ala Arg Gly Ile Thr Ile Asn
            100                 105                 110         
Ala Ala His Val Glu Tyr Ser Thr Ala Ala Arg His Tyr Ala His Thr
        115                 120                 125             
Asp Cys Pro Gly His Ala Asp Tyr Val Lys Asn Met Ile Thr Gly Thr
    130                 135                 140                 
Ala Pro Leu Asp Gly Cys Ile Leu Val Val Ala Ala Asn Asp Gly Pro
145                 150                 155                 160 
Met Pro Gln Thr Arg Glu His Leu Leu Leu Ala Arg Gln Ile Gly Val
                165                 170                 175     
Glu His Val Val Val Tyr Val Asn Lys Ala Asp Ala Val Gln Asp Ser
            180                 185                 190         
Glu Met Val Glu Leu Glu Ile Arg Glu Leu Leu Thr Glu Phe Gly Tyr
        195                 200                 205             
Lys Gly Glu Glu Thr Pro Val Ile Val Gly Ser Ala Leu Cys Ala Leu
    210                 215                 220                 
Glu Gly Arg Asp Pro Glu Leu Gly Leu Lys Ser Val Gln Lys Leu Leu
225                 230                 235                 240 
Asp Ala Val Asp Thr Tyr Ile Pro Val Pro Ala Arg Asp Leu Glu Lys
                245                 250                 255     
Pro Phe Leu Leu Pro Val Glu Ala Val Tyr Ser Val Pro Gly Arg Gly
            260                 265                 270         
Thr Val Val Thr Gly Thr Leu Glu Arg Gly Ile Leu Lys Lys Gly Asp
        275                 280                 285             
Glu Cys Glu Leu Leu Gly His Ser Lys Asn Ile Arg Thr Val Val Thr
    290                 295                 300                 
Gly Ile Glu Met Phe His Lys Ser Leu Glu Arg Ala Glu Ala Gly Asp
305                 310                 315                 320 
Asn Leu Gly Ala Leu Val Arg Gly Leu Lys Arg Glu Asp Leu Arg Arg
                325                 330                 335     
Gly Leu Val Met Val Lys Pro Gly Ser Ile Lys Pro His Gln Lys Val
            340                 345                 350         
Glu Ala Gln Val Tyr Ile Leu Ser Lys Glu Glu Gly Gly Arg His Lys
        355                 360                 365             
Pro Phe Val Ser His Phe Met Pro Val Met Phe Ser Leu Thr Trp Asp
    370                 375                 380                 
Met Ala Cys Arg Ile Ile Leu Pro Pro Glu Lys Glu Leu Ala Met Pro
385                 390                 395                 400 
Gly Glu Asp Leu Lys Phe Asn Leu Ile Leu Arg Gln Pro Met Ile Leu
                405                 410                 415     
Glu Lys Gly Gln Arg Phe Thr Leu Arg Asp Gly Asn Arg Thr Ile Gly
            420                 425                 430         
Thr Gly Leu Val Thr Asn Thr Leu Ala Met Thr Glu Glu Glu Lys Asn
        435                 440                 445             
Ile Lys Trp Gly
    450         


<210> 257
<211> 1300
<212> PRT
<213> Homo sapiens

<400> 257
Met Glu Phe Tyr Glu Ser Ala Tyr Phe Ile Val Leu Ile Pro Ser Ile
 1               5                  10                  15      
Val Ile Thr Val Ile Phe Leu Phe Phe Trp Leu Phe Met Lys Glu Thr
            20                  25                  30          
Leu Tyr Asp Glu Val Leu Ala Lys Gln Lys Arg Glu Gln Lys Leu Ile
        35                  40                  45              
Pro Thr Lys Thr Asp Lys Lys Lys Ala Glu Lys Lys Lys Asn Lys Lys
    50                  55                  60                  
Lys Glu Ile Gln Asn Gly Asn Leu His Glu Ser Asp Ser Glu Ser Val
65                  70                  75                  80  
Pro Arg Asp Phe Lys Leu Ser Asp Ala Leu Ala Val Glu Asp Asp Gln
                85                  90                  95      
Val Ala Pro Val Pro Leu Asn Val Val Glu Thr Ser Ser Ser Val Arg
            100                 105                 110         
Glu Arg Lys Lys Lys Glu Lys Lys Gln Lys Pro Val Leu Glu Glu Gln
        115                 120                 125             
Val Ile Lys Glu Ser Asp Ala Ser Lys Ile Pro Gly Lys Lys Val Glu
    130                 135                 140                 
Pro Val Pro Val Thr Lys Gln Pro Thr Pro Pro Ser Glu Ala Ala Ala
145                 150                 155                 160 
Ser Lys Lys Lys Pro Gly Gln Lys Lys Ser Lys Asn Gly Ser Asp Asp
                165                 170                 175     
Gln Asp Lys Lys Val Glu Thr Leu Met Val Pro Ser Lys Arg Gln Glu
            180                 185                 190         
Ala Leu Pro Leu His Gln Glu Thr Lys Gln Glu Ser Gly Ser Gly Lys
        195                 200                 205             
Lys Lys Ala Ser Ser Lys Lys Gln Lys Thr Glu Asn Val Phe Val Asp
    210                 215                 220                 
Glu Pro Leu Ile His Ala Thr Thr Tyr Ile Pro Leu Met Asp Asn Ala
225                 230                 235                 240 
Asp Ser Ser Pro Val Val Asp Lys Arg Glu Val Ile Asp Leu Leu Lys
                245                 250                 255     
Pro Asp Gln Val Glu Gly Ile Gln Lys Ser Gly Thr Lys Lys Leu Lys
            260                 265                 270         
Thr Glu Thr Asp Lys Glu Asn Ala Glu Val Lys Phe Lys Asp Phe Leu
        275                 280                 285             
Leu Ser Leu Lys Thr Met Met Phe Ser Glu Asp Glu Ala Leu Cys Val
    290                 295                 300                 
Val Asp Leu Leu Lys Glu Lys Ser Gly Val Ile Gln Asp Ala Leu Lys
305                 310                 315                 320 
Lys Ser Ser Lys Gly Glu Leu Thr Thr Leu Ile His Gln Leu Gln Glu
                325                 330                 335     
Lys Asp Lys Leu Leu Ala Ala Val Lys Glu Asp Ala Ala Ala Thr Lys
            340                 345                 350         
Asp Arg Cys Lys Gln Leu Thr Gln Glu Met Met Thr Glu Lys Glu Arg
        355                 360                 365             
Ser Asn Val Val Ile Thr Arg Met Lys Asp Arg Ile Gly Thr Leu Glu
    370                 375                 380                 
Lys Glu His Asn Val Phe Gln Asn Lys Ile His Val Ser Tyr Gln Glu
385                 390                 395                 400 
Thr Gln Gln Met Gln Met Lys Phe Gln Gln Val Arg Glu Gln Met Glu
                405                 410                 415     
Ala Glu Ile Ala His Leu Lys Gln Glu Asn Gly Ile Leu Arg Asp Ala
            420                 425                 430         
Val Ser Asn Thr Thr Asn Gln Leu Glu Ser Lys Gln Ser Ala Glu Leu
        435                 440                 445             
Asn Lys Leu Arg Gln Asp Tyr Ala Arg Leu Val Asn Glu Leu Thr Glu
    450                 455                 460                 
Lys Thr Gly Lys Leu Gln Gln Glu Glu Val Gln Lys Lys Asn Ala Glu
465                 470                 475                 480 
Gln Ala Ala Thr Gln Leu Lys Val Gln Leu Gln Glu Ala Glu Arg Arg
                485                 490                 495     
Trp Glu Glu Val Gln Ser Tyr Ile Arg Lys Arg Thr Ala Glu His Glu
            500                 505                 510         
Ala Ala Gln Gln Asp Leu Gln Ser Lys Phe Val Ala Lys Glu Asn Glu
        515                 520                 525             
Val Gln Ser Leu His Ser Lys Leu Thr Asp Thr Leu Val Ser Lys Gln
    530                 535                 540                 
Gln Leu Glu Gln Arg Leu Met Gln Leu Met Glu Ser Glu Gln Lys Arg
545                 550                 555                 560 
Val Asn Lys Glu Glu Ser Leu Gln Met Gln Val Gln Asp Ile Leu Glu
                565                 570                 575     
Gln Asn Glu Ala Leu Lys Ala Gln Ile Gln Gln Phe His Ser Gln Ile
            580                 585                 590         
Ala Ala Gln Thr Ser Ala Ser Val Leu Ala Glu Glu Leu His Lys Val
        595                 600                 605             
Ile Ala Glu Lys Asp Lys Gln Ile Lys Gln Thr Glu Asp Ser Leu Ala
    610                 615                 620                 
Ser Glu Arg Asp Arg Leu Thr Ser Lys Glu Glu Glu Leu Lys Asp Ile
625                 630                 635                 640 
Gln Asn Met Asn Phe Leu Leu Lys Ala Glu Val Gln Lys Leu Gln Ala
                645                 650                 655     
Leu Ala Asn Glu Gln Ala Ala Ala Ala His Glu Leu Glu Lys Met Gln
            660                 665                 670         
Gln Ser Val Tyr Val Lys Asp Asp Lys Ile Arg Leu Leu Glu Glu Gln
        675                 680                 685             
Leu Gln His Glu Ile Ser Asn Lys Met Glu Glu Phe Lys Ile Leu Asn
    690                 695                 700                 
Asp Gln Asn Lys Ala Leu Lys Ser Glu Val Gln Lys Leu Gln Thr Leu
705                 710                 715                 720 
Val Ser Glu Gln Pro Asn Lys Asp Val Val Glu Gln Met Glu Lys Cys
                725                 730                 735     
Ile Gln Glu Lys Asp Glu Lys Leu Lys Thr Val Glu Glu Leu Leu Glu
            740                 745                 750         
Thr Gly Leu Ile Gln Val Ala Thr Lys Glu Glu Glu Leu Asn Ala Ile
        755                 760                 765             
Arg Thr Glu Asn Ser Ser Leu Thr Lys Glu Val Gln Asp Leu Lys Ala
    770                 775                 780                 
Lys Gln Asn Asp Gln Val Ser Phe Ala Ser Leu Val Glu Glu Leu Lys
785                 790                 795                 800 
Lys Val Ile His Glu Lys Asp Gly Lys Ile Lys Ser Val Glu Glu Leu
                805                 810                 815     
Leu Glu Ala Glu Leu Leu Lys Val Ala Asn Lys Glu Lys Thr Val Gln
            820                 825                 830         
Asp Leu Lys Gln Glu Ile Lys Ala Leu Lys Glu Glu Ile Gly Asn Val
        835                 840                 845             
Gln Leu Glu Lys Ala Gln Gln Leu Ser Ile Thr Ser Lys Val Gln Glu
    850                 855                 860                 
Leu Gln Asn Leu Leu Lys Gly Lys Glu Glu Gln Met Asn Thr Met Lys
865                 870                 875                 880 
Ala Val Leu Glu Glu Lys Glu Lys Asp Leu Ala Asn Thr Gly Lys Trp
                885                 890                 895     
Leu Gln Asp Leu Gln Glu Glu Asn Glu Ser Leu Lys Ala His Val Gln
            900                 905                 910         
Glu Val Ala Gln His Asn Leu Lys Glu Ala Ser Ser Ala Ser Gln Phe
        915                 920                 925             
Glu Glu Leu Glu Ile Val Leu Lys Glu Lys Glu Asn Glu Leu Lys Arg
    930                 935                 940                 
Leu Glu Ala Met Leu Lys Glu Arg Glu Ser Asp Leu Ser Ser Lys Thr
945                 950                 955                 960 
Gln Leu Leu Gln Asp Val Gln Asp Glu Asn Lys Leu Phe Lys Ser Gln
                965                 970                 975     
Ile Glu Gln Leu Lys Gln Gln Asn Tyr Gln Gln Ala Ser Ser Phe Pro
            980                 985                 990         
Pro His Glu Glu Leu Leu Lys Val Ile Ser Glu Arg Glu Lys Glu Ile
        995                 1000                1005            
Ser Gly Leu Trp Asn Glu Leu Asp Ser Leu Lys Asp Ala Val Glu His
    1010                1015                1020                
Gln Arg Lys Lys Asn Asn Glu Arg Gln Gln Gln Val Glu Ala Val Glu
1025                1030                1035                1040
Leu Glu Ala Lys Glu Val Leu Lys Lys Leu Phe Pro Lys Val Ser Val
                1045                1050                1055    
Pro Ser Asn Leu Ser Tyr Gly Glu Trp Leu His Gly Phe Glu Lys Lys
            1060                1065                1070        
Ala Lys Glu Cys Met Ala Gly Thr Ser Gly Ser Glu Glu Val Lys Val
        1075                1080                1085            
Leu Glu His Lys Leu Lys Glu Ala Asp Glu Met His Thr Leu Leu Gln
    1090                1095                1100                
Leu Glu Cys Glu Lys Tyr Lys Ser Val Leu Ala Glu Thr Glu Gly Ile
1105                1110                1115                1120
Leu Gln Lys Leu Gln Arg Ser Val Glu Gln Glu Glu Asn Lys Trp Lys
                1125                1130                1135    
Val Lys Val Asp Glu Ser His Lys Thr Ile Lys Gln Met Gln Ser Ser
            1140                1145                1150        
Phe Thr Ser Ser Glu Gln Glu Leu Glu Arg Leu Arg Ser Glu Asn Lys
        1155                1160                1165            
Asp Ile Glu Asn Leu Arg Arg Glu Arg Glu His Leu Glu Met Glu Leu
    1170                1175                1180                
Glu Lys Ala Glu Met Glu Arg Ser Thr Tyr Val Thr Glu Val Arg Glu
1185                1190                1195                1200
Leu Lys Ala Gln Leu Asn Glu Thr Leu Thr Lys Leu Arg Thr Glu Gln
                1205                1210                1215    
Asn Glu Arg Gln Lys Val Ala Gly Asp Leu His Lys Ala Gln Gln Ser
            1220                1225                1230        
Leu Glu Leu Ile Gln Ser Lys Ile Val Lys Ala Ala Gly Asp Thr Thr
        1235                1240                1245            
Val Ile Glu Asn Ser Asp Val Ser Pro Glu Thr Glu Ser Ser Glu Lys
    1250                1255                1260                
Glu Thr Met Ser Val Ser Leu Asn Gln Thr Val Thr Gln Leu Gln Gln
1265                1270                1275                1280
Leu Leu Gln Ala Val Asn Gln Gln Leu Thr Lys Glu Lys Glu His Tyr
                1285                1290                1295    
Gln Val Leu Glu
            1300


<210> 258
<211> 199
<212> PRT
<213> Homo sapiens

<400> 258
Met Ser Ser Gly Asn Ala Lys Ile Gly His Pro Ala Pro Asn Phe Lys
 1               5                  10                  15      
Ala Thr Ala Val Met Pro Asp Gly Gln Phe Lys Asp Ile Ser Leu Ser
            20                  25                  30          
Asp Tyr Lys Gly Lys Tyr Val Val Phe Phe Phe Tyr Pro Leu Asp Phe
        35                  40                  45              
Thr Phe Val Cys Pro Thr Glu Ile Ile Ala Phe Ser Asp Arg Ala Glu
    50                  55                  60                  
Glu Phe Lys Lys Leu Asn Cys Gln Val Ile Gly Ala Ser Val Asp Ser
65                  70                  75                  80  
His Phe Cys His Leu Ala Trp Val Asn Thr Pro Lys Lys Gln Gly Gly
                85                  90                  95      
Leu Gly Pro Met Asn Ile Pro Leu Val Ser Asp Pro Lys Arg Thr Ile
            100                 105                 110         
Ala Gln Asp Tyr Gly Val Leu Lys Ala Asp Glu Gly Ile Ser Phe Arg
        115                 120                 125             
Gly Leu Phe Ile Ile Asp Asp Lys Gly Ile Leu Arg Gln Ile Thr Val
    130                 135                 140                 
Asn Asp Pro Pro Cys Cys Arg Ser Val Asp Glu Thr Leu Arg Leu Val
145                 150                 155                 160 
Gln Ala Phe Gln Phe Thr Asp Lys His Gly Glu Val Cys Pro Ala Gly
                165                 170                 175     
Trp Lys Pro Gly Ser Asp Thr Ile Lys Pro Asp Val Pro Lys Thr Lys
            180                 185                 190         
Glu Tyr Phe Ser Lys Gln Lys
        195                 


<210> 259
<211> 438
<212> PRT
<213> Homo sapiens

<400> 259
Gly Gly Gly Gly Gly His Ile Gly Val Arg Pro Gly Ser Thr Leu Cys
 1               5                  10                  15      
Gln Ile Ile Ala Thr Cys His Met Ser Val Asn Asp Gly Gly Cys Lys
            20                  25                  30          
Tyr Val Leu Cys Arg Trp Glu Lys Arg Leu Trp Pro Ala Lys Val Leu
        35                  40                  45              
Ala Arg Thr Ala Thr Ser Thr Lys Asn Lys Arg Arg Lys Glu Tyr Phe
    50                  55                  60                  
Leu Ala Val Gln Ile Leu Ser Leu Glu Glu Lys Ile Lys Val Lys Ser
65                  70                  75                  80  
Thr Glu Val Glu Ile Leu Glu Lys Ser Gln Ile Glu Ala Ile Ala Ser
                85                  90                  95      
Ser Leu Ala Ser Gln Asn Glu Val Pro Ala Ala Pro Leu Glu Glu Leu
            100                 105                 110         
Ala Tyr Arg Arg Ser Leu Arg Val Ala Leu Asp Val Leu Ser Glu Gly
        115                 120                 125             
Ser Ile Trp Ser Gln Glu Ser Ser Ala Gly Thr Gly Arg Ala Asp Arg
    130                 135                 140                 
Ser Leu Arg Gly Lys Pro Met Glu His Val Ser Ser Pro Cys Asp Ser
145                 150                 155                 160 
Asn Ser Ser Ser Leu Pro Arg Gly Asp Val Leu Gly Ser Ser Arg Pro
                165                 170                 175     
His Arg Arg Arg Pro Cys Val Gln Gln Ser Leu Ser Ser Ser Phe Thr
            180                 185                 190         
Cys Glu Lys Asp Pro Glu Cys Lys Val Asp His Lys Lys Gly Leu Arg
        195                 200                 205             
Lys Ser Glu Asn Pro Arg Gly Pro Leu Val Leu Pro Ala Gly Gly Gly
    210                 215                 220                 
Ala Gln Asp Glu Ser Gly Ser Arg Ile His His Lys Asn Trp Thr Leu
225                 230                 235                 240 
Ala Ser Lys Arg Gly Arg Asn Ser Ala Gln Lys Ala Ser Leu Cys Leu
                245                 250                 255     
Asn Gly Ser Ser Leu Ser Glu Asp Asp Thr Glu Arg Asp Met Gly Ser
            260                 265                 270         
Lys Gly Gly Ser Trp Ala Ala Pro Ser Leu Pro Ser Gly Val Arg Glu
        275                 280                 285             
Asp Asp Pro Cys Ala Asn Ala Glu Gly His Asp Pro Gly Leu Pro Leu
    290                 295                 300                 
Gly Ser Leu Thr Ala Pro Pro Ala Pro Glu Pro Ser Ala Cys Ser Glu
305                 310                 315                 320 
Pro Gly Glu Cys Pro Ala Lys Lys Arg Pro Arg Leu Asp Gly Ser Gln
                325                 330                 335     
Arg Pro Pro Ala Val Gln Leu Glu Pro Met Ala Ala Gly Ala Ala Pro
            340                 345                 350         
Ser Pro Gly Pro Gly Pro Gly Pro Arg Glu Ser Val Thr Pro Arg Ser
        355                 360                 365             
Thr Ala Arg Leu Gly Pro Pro Pro Ser His Ala Ser Ala Asp Ala Thr
    370                 375                 380                 
Arg Cys Leu Pro Cys Pro Asp Ser Gln Lys Leu Glu Lys Glu Cys Gln
385                 390                 395                 400 
Ser Ser Glu Glu Ser Met Gly Ser Asn Ser Met Arg Ser Ile Leu Glu
                405                 410                 415     
Glu Asp Glu Glu Asp Glu Glu Pro Pro Arg Val Leu Leu Tyr His Glu
            420                 425                 430         
Pro Arg Ser Phe Glu Val
        435             


<210> 260
<211> 140
<212> PRT
<213> Homo sapiens

<400> 260
Asn Arg Pro Thr Ser Ile Ser Trp Asp Gly Leu Asp Ser Gly Lys Leu
 1               5                  10                  15      
Tyr Thr Leu Val Leu Thr Asp Pro Asp Ala Pro Ser Arg Lys Asp Pro
            20                  25                  30          
Lys Tyr Arg Glu Trp His His Phe Leu Val Val Asn Met Lys Gly Asn
        35                  40                  45              
Asp Ile Ser Ser Gly Thr Val Leu Ser Asp Tyr Val Gly Ser Gly Pro
    50                  55                  60                  
Pro Lys Gly Thr Gly Leu His Arg Tyr Val Trp Leu Val Tyr Glu Gln
65                  70                  75                  80  
Asp Arg Pro Leu Lys Cys Asp Glu Pro Ile Leu Ser Asn Arg Ser Gly
                85                  90                  95      
Asp His Arg Gly Lys Phe Lys Val Ala Ser Phe Arg Lys Lys Tyr Glu
            100                 105                 110         
Leu Arg Ala Pro Val Ala Gly Thr Cys Tyr Gln Ala Glu Trp Asp Asp
        115                 120                 125             
Tyr Val Pro Lys Leu Tyr Glu Gln Leu Ser Gly Lys
    130                 135                 140 


<210> 261
<211> 886
<212> PRT
<213> Homo sapiens

<400> 261
Met Glu Pro Pro Thr Val Pro Ser Glu Arg Ser Leu Ser Leu Ser Leu
 1               5                  10                  15      
Pro Gly Pro Arg Glu Gly Gln Ala Thr Leu Lys Pro Pro Pro Gln His
            20                  25                  30          
Leu Trp Arg Gln Pro Arg Thr Pro Ile Arg Ile Gln Gln Arg Gly Tyr
        35                  40                  45              
Ser Asp Ser Ala Glu Arg Ala Glu Arg Glu Arg Gln Pro His Arg Pro
    50                  55                  60                  
Ile Glu Arg Ala Asp Ala Met Asp Thr Ser Asp Arg Pro Gly Leu Arg
65                  70                  75                  80  
Thr Thr Arg Met Ser Trp Pro Ser Ser Phe His Gly Thr Gly Thr Gly
                85                  90                  95      
Ser Gly Gly Ala Gly Gly Gly Ser Ser Arg Arg Phe Glu Ala Glu Asn
            100                 105                 110         
Gly Pro Thr Pro Ser Pro Gly Arg Ser Pro Leu Asp Ser Gln Ala Ser
        115                 120                 125             
Pro Gly Leu Val Leu His Ala Gly Ala Ala Thr Ser Gln Arg Arg Glu
    130                 135                 140                 
Ser Phe Leu Tyr Arg Ser Asp Ser Asp Tyr Asp Met Ser Pro Lys Thr
145                 150                 155                 160 
Met Ser Arg Asn Ser Ser Val Thr Ser Glu Ala His Ala Glu Asp Leu
                165                 170                 175     
Ile Val Thr Pro Phe Ala Gln Val Leu Ala Ser Leu Arg Ser Val Arg
            180                 185                 190         
Ser Asn Phe Ser Leu Leu Thr Asn Val Pro Val Pro Ser Asn Lys Arg
        195                 200                 205             
Ser Pro Leu Gly Gly Pro Thr Pro Val Cys Lys Ala Thr Leu Ser Glu
    210                 215                 220                 
Glu Thr Cys Gln Gln Leu Ala Arg Glu Thr Leu Glu Glu Leu Asp Trp
225                 230                 235                 240 
Cys Leu Glu Gln Leu Glu Thr Met Gln Thr Tyr Arg Ser Val Ser Glu
                245                 250                 255     
Met Ala Ser His Lys Phe Lys Arg Met Leu Asn Arg Glu Leu Thr His
            260                 265                 270         
Leu Ser Glu Met Ser Arg Ser Gly Asn Gln Val Ser Glu Tyr Ile Ser
        275                 280                 285             
Thr Thr Phe Leu Asp Lys Gln Asn Glu Val Glu Ile Pro Ser Pro Thr
    290                 295                 300                 
Met Lys Glu Arg Glu Lys Gln Gln Ala Pro Arg Pro Arg Pro Ser Gln
305                 310                 315                 320 
Pro Pro Pro Pro Pro Val Pro His Leu Gln Pro Met Ser Gln Ile Thr
                325                 330                 335     
Gly Leu Lys Lys Leu Met His Ser Asn Ser Leu Asn Asn Ser Asn Ile
            340                 345                 350         
Pro Arg Phe Gly Val Lys Thr Asp Gln Glu Glu Leu Leu Ala Gln Glu
        355                 360                 365             
Leu Glu Asn Leu Asn Lys Trp Gly Leu Asn Ile Phe Cys Val Ser Asp
    370                 375                 380                 
Tyr Ala Gly Gly Arg Ser Leu Thr Cys Ile Met Tyr Met Ile Phe Gln
385                 390                 395                 400 
Glu Arg Asp Leu Leu Lys Lys Phe Arg Ile Pro Val Asp Thr Met Val
                405                 410                 415     
Thr Tyr Met Leu Thr Leu Glu Asp His Tyr His Ala Asp Val Ala Tyr
            420                 425                 430         
His Asn Ser Leu His Ala Ala Asp Val Leu Gln Ser Thr His Val Leu
        435                 440                 445             
Leu Ala Thr Pro Ala Leu Asp Ala Val Phe Thr Asp Leu Glu Ile Leu
    450                 455                 460                 
Ala Ala Leu Phe Ala Ala Ala Ile His Asp Val Asp His Pro Gly Val
465                 470                 475                 480 
Ser Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr
                485                 490                 495     
Asn Asp Glu Ser Val Leu Glu Asn His His Leu Ala Val Gly Phe Lys
            500                 505                 510         
Leu Leu Gln Glu Asp Asn Cys Asp Ile Phe Gln Asn Leu Ser Lys Arg
        515                 520                 525             
Gln Arg Gln Ser Leu Arg Lys Met Val Ile Asp Met Val Leu Ala Thr
    530                 535                 540                 
Asp Met Ser Lys His Met Thr Leu Leu Ala Asp Leu Lys Thr Met Val
545                 550                 555                 560 
Glu Thr Lys Lys Val Thr Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr
                565                 570                 575     
Ser Asp Arg Ile Gln Val Leu Arg Asn Met Val His Cys Ala Asp Leu
            580                 585                 590         
Ser Asn Pro Thr Lys Pro Leu Glu Leu Tyr Arg Gln Trp Thr Asp Arg
        595                 600                 605             
Ile Met Ala Glu Phe Phe Gln Gln Gly Asp Arg Glu Arg Glu Arg Gly
    610                 615                 620                 
Met Glu Ile Ser Pro Met Cys Asp Lys His Thr Ala Ser Val Glu Lys
625                 630                 635                 640 
Ser Gln Val Gly Phe Ile Asp Tyr Ile Val His Pro Leu Trp Glu Thr
                645                 650                 655     
Trp Ala Asp Leu Val His Pro Asp Ala Gln Glu Ile Leu Asp Thr Leu
            660                 665                 670         
Glu Asp Asn Arg Asp Trp Tyr Tyr Ser Ala Ile Arg Gln Ser Pro Ser
        675                 680                 685             
Pro Pro Pro Glu Glu Glu Ser Arg Gly Pro Gly His Pro Pro Leu Pro
    690                 695                 700                 
Asp Lys Phe Gln Phe Glu Leu Thr Leu Glu Glu Glu Glu Glu Glu Glu
705                 710                 715                 720 
Ile Ser Met Ala Gln Ile Pro Cys Thr Ala Gln Glu Ala Leu Thr Ala
                725                 730                 735     
Gln Gly Leu Ser Gly Val Glu Glu Ala Leu Asp Ala Thr Ile Ala Trp
            740                 745                 750         
Glu Ala Ser Pro Ala Gln Glu Ser Leu Glu Val Met Ala Gln Glu Ala
        755                 760                 765             
Ser Leu Glu Ala Glu Leu Glu Ala Val Tyr Leu Thr Gln Gln Ala Gln
    770                 775                 780                 
Ser Thr Gly Ser Ala Pro Val Ala Pro Asp Glu Phe Ser Ser Arg Glu
785                 790                 795                 800 
Glu Phe Val Val Ala Val Ser His Ser Ser Pro Ser Ala Leu Ala Leu
                805                 810                 815     
Gln Ser Pro Leu Leu Pro Ala Trp Arg Thr Leu Ser Val Ser Glu His
            820                 825                 830         
Ala Pro Gly Leu Pro Gly Leu Pro Ser Thr Ala Ala Glu Val Glu Ala
        835                 840                 845             
Gln Arg Glu His Gln Ala Ala Lys Arg Ala Cys Ser Ala Cys Ala Gly
    850                 855                 860                 
Thr Phe Gly Glu Asp Thr Ser Ala Leu Pro Ala Pro Gly Gly Gly Gly
865                 870                 875                 880 
Ser Gly Gly Asp Pro Thr
                885     


<210> 262
<211> 323
<212> PRT
<213> Homo sapiens

<400> 262
Arg Lys Val Gly Ala Ala Leu Ala Ala Gly Cys Thr Val Val Val Lys
 1               5                  10                  15      
Pro Ala Glu Asp Thr Pro Phe Ser Ala Leu Ala Leu Ala Glu Leu Ala
            20                  25                  30          
Ser Gln Ala Gly Ile Pro Ser Gly Val Tyr Asn Val Ile Pro Cys Ser
        35                  40                  45              
Arg Lys Asn Ala Lys Glu Val Gly Glu Ala Ile Cys Thr Asp Pro Leu
    50                  55                  60                  
Val Ser Lys Ile Ser Phe Thr Gly Ser Thr Thr Thr Gly Lys Ile Leu
65                  70                  75                  80  
Leu His His Ala Ala Asn Ser Val Lys Arg Val Ser Met Glu Leu Gly
                85                  90                  95      
Gly Leu Ala Pro Phe Ile Val Phe Asp Ser Ala Asn Val Asp Gln Ala
            100                 105                 110         
Val Ala Gly Ala Met Ala Ser Lys Phe Arg Asn Thr Gly Gln Thr Cys
        115                 120                 125             
Val Cys Ser Asn Gln Phe Leu Val Gln Arg Gly Ile His Asp Ala Phe
    130                 135                 140                 
Val Lys Ala Phe Ala Glu Ala Met Lys Lys Asn Leu Arg Val Gly Asn
145                 150                 155                 160 
Gly Phe Glu Glu Gly Thr Thr Gln Gly Pro Leu Ile Asn Glu Lys Ala
                165                 170                 175     
Val Glu Lys Val Glu Lys Gln Val Asn Asp Ala Val Ser Lys Gly Ala
            180                 185                 190         
Thr Val Val Thr Gly Gly Lys Arg His Gln Leu Gly Lys Asn Phe Phe
        195                 200                 205             
Glu Pro Thr Leu Leu Cys Asn Val Thr Gln Asp Met Leu Cys Thr His
    210                 215                 220                 
Glu Glu Thr Phe Gly Pro Leu Ala Pro Val Ile Lys Phe Asp Thr Glu
225                 230                 235                 240 
Glu Glu Ala Ile Ala Ile Ala Asn Ala Ala Asp Val Gly Leu Ala Gly
                245                 250                 255     
Tyr Phe Tyr Ser Gln Asp Pro Ala Gln Ile Trp Arg Val Ala Glu Gln
            260                 265                 270         
Leu Glu Val Gly Met Val Gly Val Asn Glu Gly Leu Ile Ser Ser Val
        275                 280                 285             
Glu Cys Pro Phe Gly Gly Val Lys Gln Ser Gly Leu Gly Arg Glu Gly
    290                 295                 300                 
Ser Lys Tyr Gly Ile Asp Glu Tyr Leu Glu Leu Lys Tyr Val Cys Tyr
305                 310                 315                 320 
Gly Gly Leu
            


<210> 263
<211> 1972
<212> PRT
<213> Homo sapiens

<400> 263
Met Gly Asp Asp Ser Glu Trp Leu Lys Leu Pro Val Asp Gln Lys Cys
 1               5                  10                  15      
Glu His Lys Leu Trp Lys Ala Arg Leu Ser Gly Tyr Glu Glu Ala Leu
            20                  25                  30          
Lys Ile Phe Gln Lys Ile Lys Asp Glu Lys Ser Pro Glu Trp Ser Lys
        35                  40                  45              
Phe Leu Gly Leu Ile Lys Lys Phe Val Thr Asp Ser Asn Ala Val Val
    50                  55                  60                  
Gln Leu Lys Gly Leu Glu Ala Ala Leu Val Tyr Val Glu Asn Ala His
65                  70                  75                  80  
Val Ala Gly Lys Thr Thr Gly Glu Val Val Ser Gly Val Val Ser Lys
                85                  90                  95      
Val Phe Asn Gln Pro Lys Ala Lys Ala Lys Glu Leu Gly Ile Glu Ile
            100                 105                 110         
Cys Leu Met Tyr Ile Glu Ile Glu Lys Gly Glu Ala Val Gln Glu Glu
        115                 120                 125             
Leu Leu Lys Gly Leu Asp Asn Lys Asn Pro Lys Ile Ile Val Ala Cys
    130                 135                 140                 
Ile Glu Thr Leu Arg Lys Ala Leu Ser Glu Phe Gly Ser Lys Ile Ile
145                 150                 155                 160 
Leu Leu Lys Pro Ile Ile Lys Val Leu Pro Lys Leu Phe Glu Ser Arg
                165                 170                 175     
Glu Lys Ala Val Arg Asp Glu Ala Lys Leu Ile Ala Val Glu Ile Tyr
            180                 185                 190         
Arg Trp Ile Arg Asp Ala Leu Arg Pro Pro Leu Gln Asn Ile Asn Ser
        195                 200                 205             
Val Gln Leu Lys Glu Leu Glu Glu Glu Trp Val Lys Leu Pro Thr Ser
    210                 215                 220                 
Ala Pro Arg Pro Thr Arg Phe Leu Arg Ser Gln Gln Glu Leu Glu Ala
225                 230                 235                 240 
Lys Leu Glu Gln Gln Gln Ser Ala Gly Gly Asp Ala Glu Gly Gly Gly
                245                 250                 255     
Asp Asp Gly Asp Glu Val Pro Gln Ile Asp Ala Tyr Glu Leu Leu Glu
            260                 265                 270         
Ala Val Glu Ile Leu Ser Lys Leu Pro Lys Asp Phe Tyr Asp Lys Ile
        275                 280                 285             
Glu Ala Lys Lys Trp Gln Glu Arg Lys Glu Ala Leu Glu Ser Val Glu
    290                 295                 300                 
Val Leu Ile Lys Asn Pro Lys Leu Glu Ala Gly Asp Tyr Ala Asp Leu
305                 310                 315                 320 
Val Lys Ala Leu Lys Lys Val Val Gly Lys Asp Thr Asn Val Met Leu
                325                 330                 335     
Val Ala Leu Ala Ala Lys Cys Leu Thr Gly Leu Ala Val Gly Leu Arg
            340                 345                 350         
Lys Lys Phe Gly Gln Tyr Ala Gly His Val Val Pro Thr Ile Leu Glu
        355                 360                 365             
Lys Phe Lys Glu Lys Lys Pro Gln Val Val Gln Ala Leu Gln Glu Ala
    370                 375                 380                 
Ile Asp Ala Ile Phe Leu Thr Thr Thr Leu Gln Asn Ile Ser Glu Asp
385                 390                 395                 400 
Val Leu Ala Val Met Asp Asn Lys Asn Pro Thr Ile Lys Gln Gln Thr
                405                 410                 415     
Ser Leu Phe Ile Ala Arg Ser Phe Arg His Cys Thr Ala Ser Thr Leu
            420                 425                 430         
Pro Lys Ser Leu Leu Lys Pro Phe Cys Ala Ala Leu Leu Lys His Ile
        435                 440                 445             
Asn Asp Ser Ala Pro Glu Val Arg Asp Ala Ala Phe Glu Ala Leu Gly
    450                 455                 460                 
Thr Ala Leu Lys Val Val Gly Glu Lys Ala Val Lys Pro Phe Leu Ala
465                 470                 475                 480 
Asp Val Asp Lys Leu Lys Leu Asp Lys Ile Lys Glu Cys Ser Glu Lys
                485                 490                 495     
Val Glu Leu Ile His Gly Lys Lys Ala Gly Leu Ala Ala Asp Lys Lys
            500                 505                 510         
Glu Phe Lys Pro Leu Pro Gly Arg Thr Ala Ala Ser Gly Ala Ala Gly
        515                 520                 525             
Asp Lys Asp Thr Lys Asp Ile Ser Ala Pro Lys Pro Gly Pro Leu Lys
    530                 535                 540                 
Lys Ala Pro Ala Ala Lys Ala Gly Gly Pro Pro Lys Lys Gly Lys Pro
545                 550                 555                 560 
Ala Ala Pro Gly Gly Ala Gly Asn Thr Gly Thr Lys Asn Lys Lys Gly
                565                 570                 575     
Leu Glu Thr Lys Glu Ile Val Glu Pro Glu Leu Ser Ile Glu Val Cys
            580                 585                 590         
Glu Glu Lys Ala Ser Ala Val Leu Pro Pro Thr Cys Ile Gln Leu Leu
        595                 600                 605             
Asp Ser Ser Asn Trp Lys Glu Arg Leu Ala Cys Met Glu Glu Phe Gln
    610                 615                 620                 
Lys Ala Val Glu Leu Met Asp Arg Thr Glu Met Pro Cys Gln Ala Leu
625                 630                 635                 640 
Val Arg Met Leu Ala Lys Lys Pro Gly Trp Lys Glu Thr Asn Phe Gln
                645                 650                 655     
Val Met Gln Met Lys Leu His Ile Val Ala Leu Ile Ala Gln Lys Gly
            660                 665                 670         
Asn Phe Ser Lys Thr Ser Ala Gln Val Val Leu Asp Gly Leu Val Asp
        675                 680                 685             
Lys Ile Gly Asp Val Lys Cys Gly Asn Asn Ala Lys Glu Ala Met Thr
    690                 695                 700                 
Ala Ile Ala Glu Ala Cys Met Leu Pro Trp Thr Ala Glu Gln Val Val
705                 710                 715                 720 
Ser Met Ala Phe Ser Gln Lys Asn Pro Lys Asn Gln Ser Glu Thr Leu
                725                 730                 735     
Asn Trp Leu Ser Asn Ala Ile Lys Glu Phe Gly Phe Ser Gly Leu Asn
            740                 745                 750         
Val Lys Ala Phe Ile Ser Asn Val Lys Thr Ala Leu Ala Ala Thr Asn
        755                 760                 765             
Pro Ala Val Arg Thr Ala Ala Ile Thr Leu Leu Gly Val Met Tyr Leu
    770                 775                 780                 
Tyr Val Gly Pro Ser Leu Arg Met Phe Phe Glu Asp Glu Lys Pro Ala
785                 790                 795                 800 
Leu Leu Ser Gln Ile Asp Ala Glu Phe Glu Lys Met Gln Gly Gln Ser
                805                 810                 815     
Pro Pro Ala Pro Thr Arg Gly Ile Ser Lys His Ser Thr Ser Gly Thr
            820                 825                 830         
Asp Glu Gly Glu Asp Gly Asp Glu Pro Asp Asp Gly Ser Asn Asp Val
        835                 840                 845             
Val Asp Leu Leu Pro Arg Thr Glu Ile Ser Asp Lys Ile Thr Ser Glu
    850                 855                 860                 
Leu Val Ser Lys Ile Gly Asp Lys Asn Trp Lys Ile Arg Lys Glu Gly
865                 870                 875                 880 
Leu Asp Glu Val Ala Gly Ile Ile Asn Asp Ala Lys Phe Ile Gln Pro
                885                 890                 895     
Asn Ile Gly Glu Leu Pro Thr Ala Leu Lys Gly Arg Leu Asn Asp Ser
            900                 905                 910         
Asn Lys Ile Leu Val Gln Gln Thr Leu Asn Ile Leu Gln Gln Leu Ala
        915                 920                 925             
Val Ala Met Gly Pro Asn Ile Lys Gln His Val Lys Asn Leu Gly Ile
    930                 935                 940                 
Pro Ile Ile Thr Val Leu Gly Asp Ser Lys Asn Asn Val Arg Ala Ala
945                 950                 955                 960 
Ala Leu Ala Thr Val Asn Ala Trp Ala Glu Gln Thr Gly Met Lys Glu
                965                 970                 975     
Trp Leu Glu Gly Glu Asp Leu Ser Glu Glu Leu Lys Lys Glu Asn Pro
            980                 985                 990         
Phe Leu Arg Gln Glu Leu Leu Gly Trp Leu Ala Glu Lys Leu Pro Thr
        995                 1000                1005            
Leu Arg Ser Thr Pro Thr Asp Leu Ile Leu Cys Val Pro His Leu Tyr
    1010                1015                1020                
Ser Cys Leu Glu Asp Arg Asn Gly Asp Val Arg Lys Lys Ala Gln Asp
1025                1030                1035                1040
Ala Leu Pro Phe Phe Met Met His Leu Gly Tyr Glu Lys Met Ala Lys
                1045                1050                1055    
Ala Thr Gly Lys Leu Lys Pro Thr Ser Lys Asp Gln Val Leu Ala Met
            1060                1065                1070        
Leu Glu Lys Ala Lys Val Asn Met Pro Ala Lys Pro Ala Pro Pro Thr
        1075                1080                1085            
Lys Ala Thr Ser Lys Pro Met Gly Gly Ser Ala Pro Ala Lys Phe Gln
    1090                1095                1100                
Pro Ala Ser Ala Pro Ala Glu Asp Cys Ile Ser Ser Ser Thr Glu Pro
1105                1110                1115                1120
Lys Pro Asp Pro Lys Lys Ala Lys Ala Pro Gly Leu Ser Ser Lys Ala
                1125                1130                1135    
Lys Ser Ala Gln Gly Lys Lys Met Pro Ser Lys Thr Ser Leu Lys Glu
            1140                1145                1150        
Asp Glu Asp Lys Ser Gly Pro Ile Phe Ile Val Val Pro Asn Gly Lys
        1155                1160                1165            
Glu Gln Arg Met Lys Asp Glu Lys Gly Leu Lys Val Leu Lys Trp Asn
    1170                1175                1180                
Phe Thr Thr Pro Arg Asp Glu Tyr Ile Glu Gln Leu Lys Thr Gln Met
1185                1190                1195                1200
Ser Ser Cys Val Ala Lys Trp Leu Gln Asp Glu Met Phe His Ser Asp
                1205                1210                1215    
Phe Gln His His Asn Lys Ala Leu Ala Val Met Val Asp His Leu Glu
            1220                1225                1230        
Ser Glu Lys Glu Gly Val Ile Gly Cys Leu Asp Leu Ile Leu Lys Trp
        1235                1240                1245            
Leu Thr Leu Arg Phe Phe Asp Thr Asn Thr Ser Val Leu Met Lys Ala
    1250                1255                1260                
Leu Glu Tyr Leu Lys Leu Leu Phe Thr Leu Leu Ser Glu Glu Glu Tyr
1265                1270                1275                1280
His Leu Thr Glu Asn Glu Ala Ser Ser Phe Ile Pro Tyr Leu Val Val
                1285                1290                1295    
Lys Val Gly Glu Pro Lys Asp Val Ile Arg Lys Asp Val Arg Ala Ile
            1300                1305                1310        
Leu Asn Arg Met Cys Leu Val Tyr Pro Ala Ser Lys Met Phe Pro Phe
        1315                1320                1325            
Ile Met Glu Gly Thr Lys Ser Lys Asn Ser Lys Gln Arg Ala Glu Cys
    1330                1335                1340                
Leu Glu Glu Leu Gly Cys Leu Val Glu Ser Tyr Gly Met Asn Val Cys
1345                1350                1355                1360
Gln Pro Thr Pro Gly Lys Ala Leu Lys Glu Ile Ala Val His Ile Gly
                1365                1370                1375    
Asp Arg Asp Asn Ala Val Arg Asn Ala Ala Leu Asn Thr Ile Val Thr
            1380                1385                1390        
Val Tyr Asn Val His Gly Asp Gln Val Phe Lys Leu Ile Gly Asn Leu
        1395                1400                1405            
Ser Glu Lys Asp Met Ser Met Leu Glu Glu Arg Ile Lys Arg Ser Ala
    1410                1415                1420                
Lys Arg Pro Ser Ala Ala Pro Ile Lys Gln Val Glu Glu Lys Pro Gln
1425                1430                1435                1440
Arg Ala Gln Asn Ile Ser Ser Asn Ala Asn Met Leu Arg Lys Gly Pro
                1445                1450                1455    
Ala Glu Asp Met Ser Ser Lys Leu Asn Gln Ala Arg Ser Met Ser Gly
            1460                1465                1470        
His Pro Glu Ala Ala Gln Met Val Arg Arg Glu Phe Gln Leu Asp Leu
        1475                1480                1485            
Asp Glu Ile Glu Asn Asp Asn Gly Thr Val Arg Cys Glu Met Pro Glu
    1490                1495                1500                
Leu Val Gln His Lys Leu Asp Asp Ile Phe Glu Pro Val Leu Ile Pro
1505                1510                1515                1520
Glu Pro Lys Ile Arg Ala Val Ser Pro His Phe Asp Asp Met His Ser
                1525                1530                1535    
Asn Thr Ala Ser Thr Ile Asn Phe Ile Ile Ser Gln Val Ala Ser Gly
            1540                1545                1550        
Asp Ile Asn Thr Ser Ile Gln Ala Leu Thr Gln Leu Phe Gln Ile Glu
        1555                1560                1565            
Ser Leu Ala Arg Glu Ala Ser Thr Gly Val Leu Lys Asp Leu Met His
    1570                1575                1580                
Gly Leu Ile Thr Leu Met Leu Asp Ser Arg Ile Glu Asp Leu Glu Glu
1585                1590                1595                1600
Gly Gln Gln Val Ile Arg Ser Val Asn Leu Leu Val Val Lys Val Leu
                1605                1610                1615    
Glu Lys Ser Asp Gln Thr Asn Ile Leu Ser Ala Leu Leu Val Leu Leu
            1620                1625                1630        
Gln Asp Ser Leu Leu Ala Thr Ala Ser Ser Pro Lys Phe Ser Glu Leu
        1635                1640                1645            
Val Met Lys Cys Leu Trp Arg Met Val Arg Leu Leu Pro Asp Thr Ile
    1650                1655                1660                
Asn Ser Ile Asn Leu Asp Arg Ile Leu Leu Asp Ile His Ile Phe Met
1665                1670                1675                1680
Lys Val Phe Pro Lys Glu Lys Leu Lys Gln Cys Lys Ser Glu Phe Pro
                1685                1690                1695    
Ile Arg Thr Leu Lys Thr Leu Leu His Thr Leu Cys Lys Leu Lys Gly
            1700                1705                1710        
Pro Lys Ile Leu Asp His Leu Thr Met Ile Asp Asn Lys Asn Glu Ser
        1715                1720                1725            
Glu Leu Glu Ala His Leu Cys Arg Met Met Lys His Ser Met Asp Gln
    1730                1735                1740                
Thr Gly Ser Lys Ser Asp Lys Glu Thr Ala Lys Gly Ala Ser Arg Ile
1745                1750                1755                1760
Asp Ala Lys Ser Ser Lys Ala Lys Val Asn Asp Phe Leu Ala Glu Ile
                1765                1770                1775    
Phe Lys Lys Ile Gly Ser Lys Glu Asn Thr Lys Glu Gly Leu Ala Glu
            1780                1785                1790        
Leu Tyr Glu Tyr Lys Lys Lys Tyr Ser Asp Ala Asp Ile Glu Pro Phe
        1795                1800                1805            
Leu Lys Asn Ser Ser Gln Phe Phe Gln Ser Tyr Val Glu Arg Gly Leu
    1810                1815                1820                
Arg Val Ile Glu Met Glu Arg Glu Gly Lys Gly Arg Ile Ser Thr Ser
1825                1830                1835                1840
Thr Gly Ile Ser Pro Gln Met Glu Val Thr Cys Val Pro Thr Pro Thr
                1845                1850                1855    
Ser Thr Val Ser Ser Ile Gly Asn Thr Asn Gly Glu Glu Val Gly Pro
            1860                1865                1870        
Ser Val Tyr Leu Glu Arg Leu Lys Ile Leu Arg Gln Arg Cys Gly Leu
        1875                1880                1885            
Asp Asn Thr Lys Gln Asp Asp Arg Pro Pro Leu Thr Ser Leu Leu Ser
    1890                1895                1900                
Lys Pro Ala Val Pro Thr Val Ala Ser Ser Thr Asp Met Leu His Ser
1905                1910                1915                1920
Lys Leu Ser Gln Leu Arg Glu Ser Arg Glu Gln His Gln His Ser Asp
                1925                1930                1935    
Leu Asp Ser Asn Gln Thr His Ser Ser Gly Thr Val Thr Ser Ser Ser
            1940                1945                1950        
Ser Thr Ala Asn Ile Asp Asp Leu Lys Lys Arg Leu Glu Arg Ile Lys
        1955                1960                1965            
Ser Ser Arg Lys
    1970        


<210> 264
<211> 359
<212> PRT
<213> Homo sapiens

<400> 264
Met Ala Ala Val Ser Gly Leu Val Arg Arg Pro Leu Arg Glu Val Ser
 1               5                  10                  15      
Gly Leu Leu Lys Arg Arg Phe His Trp Thr Ala Pro Ala Ala Leu Gln
            20                  25                  30          
Val Thr Val Arg Asp Ala Ile Asn Gln Gly Met Asp Glu Glu Leu Glu
        35                  40                  45              
Arg Asp Glu Lys Val Phe Leu Leu Gly Glu Glu Val Ala Gln Tyr Asp
    50                  55                  60                  
Gly Ala Tyr Lys Val Ser Arg Gly Leu Trp Lys Lys Tyr Gly Asp Lys
65                  70                  75                  80  
Arg Ile Ile Asp Thr Pro Ile Ser Glu Met Gly Phe Ala Gly Ile Ala
                85                  90                  95      
Val Gly Ala Ala Met Ala Gly Leu Arg Pro Ile Cys Glu Phe Met Thr
            100                 105                 110         
Phe Asn Phe Ser Met Gln Ala Ile Asp Gln Val Ile Asn Ser Ala Ala
        115                 120                 125             
Lys Thr Tyr Tyr Met Ser Gly Gly Leu Gln Pro Val Pro Ile Val Phe
    130                 135                 140                 
Arg Gly Pro Asn Gly Ala Ser Ala Gly Val Ala Ala Gln His Ser Gln
145                 150                 155                 160 
Cys Phe Ala Ala Trp Tyr Gly His Cys Pro Gly Leu Lys Val Val Ser
                165                 170                 175     
Pro Trp Asn Ser Glu Asp Ala Lys Gly Leu Ile Lys Ser Ala Ile Arg
            180                 185                 190         
Asp Asn Asn Pro Val Val Val Leu Glu Asn Glu Leu Met Tyr Gly Val
        195                 200                 205             
Pro Phe Glu Phe Pro Pro Glu Ala Gln Ser Lys Asp Phe Leu Ile Pro
    210                 215                 220                 
Ile Gly Lys Ala Lys Ile Glu Arg Gln Gly Thr His Ile Thr Val Val
225                 230                 235                 240 
Ser His Ser Arg Pro Val Gly His Cys Leu Glu Ala Ala Ala Val Leu
                245                 250                 255     
Ser Lys Glu Gly Val Glu Cys Glu Val Ile Asn Met Arg Thr Ile Arg
            260                 265                 270         
Pro Met Asp Met Glu Thr Ile Glu Ala Ser Val Met Lys Thr Asn His
        275                 280                 285             
Leu Val Thr Val Glu Gly Gly Trp Pro Gln Phe Gly Val Gly Ala Glu
    290                 295                 300                 
Ile Cys Ala Arg Ile Met Glu Gly Pro Ala Phe Asn Phe Leu Asp Ala
305                 310                 315                 320 
Pro Ala Val Arg Val Thr Gly Ala Asp Val Pro Met Pro Tyr Ala Lys
                325                 330                 335     
Ile Leu Glu Asp Asn Ser Ile Pro Gln Val Lys Asp Ile Ile Phe Ala
            340                 345                 350         
Ile Lys Lys Thr Leu Asn Ile
        355                 


<210> 265
<211> 171
<212> PRT
<213> Homo sapiens

<400> 265
Met Gly Gly Arg Ser Ser Pro Asn Gln Gly Ser Trp Arg Gly Thr Arg
 1               5                  10                  15      
Arg Ala Ser Pro Asp Trp Gly Leu Cys Trp Arg Arg Gly Arg Gly Pro
            20                  25                  30          
Arg Val Pro Ala Pro Gly Arg Ala Val Pro Val Thr Leu Pro Lys Arg
        35                  40                  45              
Leu His Arg Gly Ala Arg Ala Gln Pro Arg Gly Ala Gly Arg Asp His
    50                  55                  60                  
His Val Gln Gly Pro His Gly Ala Ala Glu Gly Gly Gly Thr Pro Glu
65                  70                  75                  80  
Leu His Val Pro Ile Arg Pro Pro Arg Pro Ser Cys Pro Gly His Arg
                85                  90                  95      
Pro Pro Ala Gly Ser Ile Pro Gln Pro Cys Arg Ala Pro Gly Pro Glu
            100                 105                 110         
Ala Ala Ala Leu His Gly Gly Thr Ala Ala Ala Arg Gly Pro Trp Val
        115                 120                 125             
Ala Pro Gly Ala Ser Gly Ala Thr Ala Val Gly Pro Ala His Gly Gln
    130                 135                 140                 
Val Gln Gly Val Leu Gly Gly Gly Arg Thr Pro Arg Leu Arg Gln Pro
145                 150                 155                 160 
Leu His Pro Ser Leu Pro Ala Ala Ser Glu Leu
                165                 170     


<210> 266
<211> 476
<212> PRT
<213> Homo sapiens

<400> 266
Glu Glu Lys Ser Glu Asp Gln Asp Leu Gln Gly Leu Lys Asp Lys Pro
 1               5                  10                  15      
Leu Lys Phe Lys Lys Val Lys Lys Asp Lys Lys Glu Glu Lys Glu Gly
            20                  25                  30          
Lys His Glu Pro Val Gln Pro Ser Ala His His Ser Ala Glu Pro Ala
        35                  40                  45              
Glu Ala Gly Lys Ala Glu Thr Ser Glu Gly Ser Gly Ser Ala Arg Leu
    50                  55                  60                  
Cys Glu Ala Ser Ala Ser Pro Lys Gln Arg Arg Ser Ile Ile Arg Asp
65                  70                  75                  80  
Arg Gly Pro Met Tyr Asp Asp Pro Thr Leu Pro Glu Gly Trp Thr Arg
                85                  90                  95      
Lys Leu Lys Gln Arg Lys Ser Gly Arg Ser Ala Gly Lys Tyr Asp Val
            100                 105                 110         
Tyr Leu Ile Asn Pro Gln Gly Lys Ala Phe Arg Ser Lys Val Glu Leu
        115                 120                 125             
Ile Ala Tyr Phe Glu Lys Val Gly Asp Thr Ser Leu Asp Pro Asn Asp
    130                 135                 140                 
Phe Asp Phe Thr Val Thr Gly Arg Gly Ser Pro Ser Arg Arg Glu Gln
145                 150                 155                 160 
Lys Pro Pro Lys Lys Pro Lys Ser Pro Lys Ala Pro Gly Thr Gly Arg
                165                 170                 175     
Gly Arg Gly Arg Pro Lys Gly Ser Gly Thr Thr Arg Pro Lys Ala Ala
            180                 185                 190         
Thr Ser Glu Gly Val Gln Val Lys Arg Val Leu Glu Lys Ser Pro Gly
        195                 200                 205             
Lys Leu Leu Val Lys Met Pro Phe Gln Thr Ser Pro Gly Gly Lys Ala
    210                 215                 220                 
Glu Gly Gly Gly Ala Thr Thr Ser Thr Gln Val Met Val Ile Lys Arg
225                 230                 235                 240 
Pro Gly Arg Lys Arg Lys Ala Glu Ala Asp Pro Gln Ala Ile Pro Lys
                245                 250                 255     
Lys Arg Gly Arg Lys Pro Gly Ser Val Val Ala Ala Ala Ala Ala Glu
            260                 265                 270         
Ala Lys Lys Lys Ala Val Lys Glu Ser Ser Ile Arg Ser Val Gln Glu
        275                 280                 285             
Thr Val Leu Pro Ile Lys Lys Arg Lys Thr Arg Glu Thr Val Ser Ile
    290                 295                 300                 
Glu Val Lys Glu Val Val Lys Pro Leu Leu Val Ser Thr Leu Gly Glu
305                 310                 315                 320 
Lys Ser Gly Lys Gly Leu Lys Thr Cys Lys Ser Pro Gly Arg Lys Ser
                325                 330                 335     
Lys Glu Ser Ser Pro Lys Gly Arg Ser Ser Ser Ala Ser Ser Pro Pro
            340                 345                 350         
Lys Lys Glu His His His His His His His Ser Glu Ser Pro Lys Ala
        355                 360                 365             
Pro Val Pro Leu Leu Pro Pro Leu Pro Pro Pro Pro Pro Glu Pro Glu
    370                 375                 380                 
Ser Ser Glu Asp Pro Thr Ser Pro Pro Glu Pro Gln Asp Leu Ser Ser
385                 390                 395                 400 
Ser Val Cys Lys Glu Glu Lys Met Pro Arg Gly Gly Ser Leu Glu Ser
                405                 410                 415     
Asp Gly Cys Pro Lys Glu Pro Ala Lys Thr Gln Pro Ala Val Ala Thr
            420                 425                 430         
Ala Ala Thr Ala Ala Glu Lys Tyr Lys His Arg Gly Glu Gly Glu Arg
        435                 440                 445             
Lys Asp Ile Val Ser Ser Ser Met Pro Arg Pro Asn Arg Glu Glu Pro
    450                 455                 460                 
Val Asp Ser Arg Thr Pro Val Thr Glu Arg Val Ser
465                 470                 475     


<210> 267
<211> 787
<212> PRT
<213> Homo sapiens

<400> 267
Met Ser Val Gln Ser Ser Ser Gly Ser Leu Glu Gly Pro Pro Ser Trp
 1               5                  10                  15      
Ser Gln Leu Ser Thr Ser Pro Thr Pro Gly Ser Ala Ala Ala Ala Arg
            20                  25                  30          
Ser Leu Leu Asn His Thr Pro Pro Ser Gly Arg Pro Arg Glu Gly Ala
        35                  40                  45              
Met Asp Glu Leu His Ser Leu Asp Pro Arg Arg Gln Glu Leu Leu Glu
    50                  55                  60                  
Ala Arg Phe Thr Gly Val Ala Ser Gly Ser Thr Gly Ser Thr Gly Ser
65                  70                  75                  80  
Cys Ser Val Gly Ala Lys Ala Ser Thr Asn Asn Glu Ser Ser Asn His
                85                  90                  95      
Ser Phe Gly Ser Leu Glu Ser Leu Ser Asp Lys Glu Ser Glu Thr Pro
            100                 105                 110         
Glu Lys Lys Gln Ser Glu Ser Ser Arg Gly Arg Lys Arg Lys Ala Glu
        115                 120                 125             
Asn Gln Asn Glu Ser Ser Gln Gly Phe Pro Asn Leu Pro Val Phe Gln
    130                 135                 140                 
Ser Leu Ala Tyr Trp Glu Met Gly Arg Thr Ala Gly Gly Lys Ser Ile
145                 150                 155                 160 
Gly Gly Arg Gly His Lys Ile Ser Asp Tyr Phe Glu Tyr Gln Gly Gly
                165                 170                 175     
Asn Gly Ser Ser Pro Val Arg Gly Ile Pro Pro Ala Ile Arg Ser Pro
            180                 185                 190         
Gln Asn Ser His Ser His Ser Thr Pro Ser Ser Ser Val Arg Pro Asn
        195                 200                 205             
Ser Pro Ser Pro Thr Ala Leu Ala Phe Gly Asp His Pro Ile Val Gln
    210                 215                 220                 
Pro Lys Gln Leu Ser Phe Lys Ile Ile Gln Thr Asp Leu Thr Met Leu
225                 230                 235                 240 
Lys Leu Ala Ala Leu Glu Ser Asn Lys Ile Leu Asp Leu Glu Lys Lys
                245                 250                 255     
Glu Gly Arg Ile Asp Asp Leu Leu Arg Ala Asn Cys Asp Leu Arg Arg
            260                 265                 270         
Gln Ile Asp Glu Gln Gln Lys Leu Leu Asp Lys Tyr Lys Glu Arg Leu
        275                 280                 285             
Asn Lys Cys Ile Ser Met Ser Lys Lys Leu Leu Ile Glu Lys Ser Thr
    290                 295                 300                 
Gln Glu Lys Leu Ser Ser Arg Glu Lys Ser Met Gln Asp Arg Leu Arg
305                 310                 315                 320 
Leu Gly His Phe Thr Thr Val Arg His Gly Ala Ser Phe Thr Glu Gln
                325                 330                 335     
Trp Thr Asp Gly Phe Ala Phe Gln Asn Leu Val Lys Gln Gln Glu Trp
            340                 345                 350         
Val Asn Gln Gln Arg Glu Asp Ile Glu Arg Gln Arg Lys Leu Leu Ala
        355                 360                 365             
Lys Arg Lys Pro Pro Thr Ala Asn Asn Ser Gln Ala Pro Ser Thr Asn
    370                 375                 380                 
Ser Glu Pro Lys Gln Arg Lys Asn Lys Ala Val Asn Gly Ala Glu Asn
385                 390                 395                 400 
Asp Pro Phe Val Arg Pro Asn Leu Pro Gln Leu Leu Thr Leu Ala Glu
                405                 410                 415     
Tyr His Glu Gln Glu Glu Ile Phe Lys Leu Arg Leu Gly His Leu Lys
            420                 425                 430         
Lys Glu Glu Ala Gly Ile Gln Ala Glu Leu Glu Arg Leu Glu Arg Val
        435                 440                 445             
Arg Asn Leu His Ile Arg Glu Leu Lys Arg Ile His Asn Glu Asp Asn
    450                 455                 460                 
Ser Gln Phe Lys Asp His Pro Thr Leu Asn Glu Arg Tyr Leu Leu Leu
465                 470                 475                 480 
His Leu Leu Gly Arg Gly Gly Phe Ser Glu Val Asp Lys Ala Phe Asp
                485                 490                 495     
Leu Ser Glu Gln Arg Tyr Ala Ala Val Lys Ile His Gln Leu Asn Lys
            500                 505                 510         
Ser Trp Arg Asp Glu Lys Lys Glu Asn Tyr His Lys His Ala Cys Arg
        515                 520                 525             
Glu Tyr Arg Ile His Lys Glu Leu Asp His Pro Arg Ile Val Lys Leu
    530                 535                 540                 
Tyr Asp Tyr Phe Ser Leu Asp Thr Asp Thr Phe Cys Thr Val Leu Glu
545                 550                 555                 560 
Tyr Cys Glu Gly Asn Asp Leu Asp Phe Tyr Leu Lys Gln His Lys Leu
                565                 570                 575     
Met Ser Glu Lys Glu Ala Arg Ser Ile Val Met Gln Ile Val Asn Ala
            580                 585                 590         
Leu Arg Tyr Leu Asn Glu Ile Lys Pro Pro Ile Ile His Tyr Asp Leu
        595                 600                 605             
Lys Pro Gly Asn Ile Leu Leu Val Asp Gly Thr Ala Cys Gly Glu Ile
    610                 615                 620                 
Lys Ile Thr Asp Phe Gly Leu Ser Lys Ile Met Asp Asp Asp Ser Tyr
625                 630                 635                 640 
Gly Val Asp Gly Met Val Leu Thr Ser Gln Gly Ala Gly Thr Tyr Trp
                645                 650                 655     
Tyr Leu Pro Pro Glu Cys Phe Val Val Gly Lys Glu Pro Pro Lys Ile
            660                 665                 670         
Ser Asn Lys Val Asp Val Trp Ser Val Gly Val Ile Phe Tyr Gln Cys
        675                 680                 685             
Leu Tyr Gly Arg Lys Pro Phe Gly His Asn Gln Ser Gln Gln Asp Ile
    690                 695                 700                 
Leu Gln Glu Asn Thr Ile Leu Lys Ala Thr Glu Val Gln Phe Pro Val
705                 710                 715                 720 
Lys Pro Val Val Ser Ser Glu Ala Lys Ala Phe Ile Arg Arg Cys Leu
                725                 730                 735     
Ala Tyr Arg Lys Glu Asp Arg Phe Asp Val His Gln Leu Ala Cys Asp
            740                 745                 750         
Pro Tyr Leu Leu Pro His Met Arg Arg Ser Asn Ser Ser Gly Asn Leu
        755                 760                 765             
His Met Ala Gly Leu Thr Ala Ser Pro Thr Pro Pro Ser Ser Ser Ile
    770                 775                 780                 
Ile Thr Tyr
785         


<210> 268
<211> 949
<212> PRT
<213> Homo sapiens

<400> 268
Gly Ser Gln Ala Gln Glu Pro Ile Leu Val Ser Ala Lys Thr Met Leu
 1               5                  10                  15      
Glu Ser Ser Ser Tyr Leu Ile Arg Thr Ala Arg Ser Leu Ala Ile Asn
            20                  25                  30          
Pro Lys Asp Pro Pro Thr Trp Ser Val Leu Ala Gly His Ser His Thr
        35                  40                  45              
Val Ser Asp Ser Ile Lys Ser Leu Ile Thr Ser Ile Arg Asp Lys Ala
    50                  55                  60                  
Pro Gly Gln Arg Glu Cys Asp Tyr Ser Ile Asp Gly Ile Asn Arg Cys
65                  70                  75                  80  
Ile Arg Asp Ile Glu Gln Ala Ser Leu Ala Ala Val Ser Gln Ser Leu
                85                  90                  95      
Ala Thr Arg Asp Asp Ile Ser Val Glu Ala Leu Gln Glu Gln Leu Thr
            100                 105                 110         
Ser Val Val Gln Glu Ile Gly His Leu Ile Asp Pro Ile Ala Thr Ala
        115                 120                 125             
Ala Arg Gly Glu Ala Ala Gln Leu Gly His Lys Val Thr Gln Leu Ala
    130                 135                 140                 
Ser Tyr Phe Glu Pro Leu Ile Leu Ala Ala Val Gly Val Ala Ser Lys
145                 150                 155                 160 
Ile Leu Asp His Gln Gln Gln Met Thr Val Leu Asp Gln Thr Lys Thr
                165                 170                 175     
Leu Ala Glu Ser Ala Leu Gln Met Leu Tyr Ala Ala Lys Glu Gly Gly
            180                 185                 190         
Gly Asn Pro Lys Ala Gln His Thr His Asp Ala Ile Thr Glu Ala Ala
        195                 200                 205             
Gln Leu Met Lys Glu Ala Val Asp Asp Ile Met Val Thr Leu Asn Glu
    210                 215                 220                 
Ala Ala Ser Glu Val Gly Leu Val Gly Gly Met Val Asp Ala Ile Ala
225                 230                 235                 240 
Glu Ala Met Ser Lys Leu Asp Glu Gly Thr Pro Pro Glu Pro Lys Gly
                245                 250                 255     
Thr Phe Val Asp Tyr Gln Thr Thr Val Val Lys Tyr Ser Lys Ala Ile
            260                 265                 270         
Ala Val Thr Ala Gln Glu Met Met Thr Lys Ser Val Thr Asn Pro Glu
        275                 280                 285             
Glu Leu Gly Gly Leu Ala Ser Gln Met Thr Ser Asp Tyr Gly His Leu
    290                 295                 300                 
Ala Phe Gln Gly Gln Met Ala Ala Ala Thr Ala Glu Pro Glu Glu Ile
305                 310                 315                 320 
Gly Phe Gln Ile Arg Thr Arg Val Gln Asp Leu Gly His Gly Cys Ile
                325                 330                 335     
Phe Leu Val Gln Lys Ala Gly Ala Leu Gln Val Cys Pro Thr Asp Ser
            340                 345                 350         
Tyr Thr Lys Arg Glu Leu Ile Glu Cys Ala Arg Ala Val Thr Glu Lys
        355                 360                 365             
Val Ser Leu Val Leu Ser Ala Leu Gln Ala Gly Asn Lys Gly Thr Gln
    370                 375                 380                 
Ala Cys Ile Thr Ala Ala Thr Ala Val Ser Gly Ile Ile Ala Asp Leu
385                 390                 395                 400 
Asp Thr Thr Ile Met Phe Ala Thr Ala Gly Thr Leu Asn Ala Glu Asn
                405                 410                 415     
Ser Glu Thr Phe Ala Asp His Arg Glu Asn Ile Leu Lys Thr Ala Lys
            420                 425                 430         
Ala Leu Val Glu Asp Thr Lys Leu Leu Val Ser Gly Ala Ala Ser Thr
        435                 440                 445             
Pro Asp Lys Leu Ala Gln Ala Ala Gln Ser Ser Ala Ala Thr Ile Thr
    450                 455                 460                 
Gln Leu Ala Glu Val Val Lys Leu Gly Ala Ala Ser Leu Gly Ser Asp
465                 470                 475                 480 
Asp Pro Glu Thr Gln Val Val Leu Ile Asn Ala Ile Lys Asp Val Ala
                485                 490                 495     
Lys Ala Leu Ser Asp Leu Ile Ser Ala Thr Lys Gly Ala Ala Ser Lys
            500                 505                 510         
Pro Val Asp Asp Pro Ser Met Tyr Gln Leu Lys Gly Ala Ala Lys Val
        515                 520                 525             
Met Val Thr Asn Val Thr Ser Leu Leu Lys Thr Val Lys Ala Val Glu
    530                 535                 540                 
Asp Glu Ala Thr Arg Gly Thr Arg Ala Leu Glu Ala Thr Ile Glu Cys
545                 550                 555                 560 
Ile Lys Gln Glu Leu Thr Val Phe Gln Ser Lys Asp Val Pro Glu Lys
                565                 570                 575     
Thr Ser Ser Pro Glu Glu Ser Ile Arg Met Thr Lys Gly Ile Thr Met
            580                 585                 590         
Ala Thr Ala Lys Ala Val Ala Ala Gly Asn Ser Cys Arg Gln Glu Asp
        595                 600                 605             
Val Ile Ala Thr Ala Asn Leu Ser Arg Lys Ala Val Ser Asp Met Leu
    610                 615                 620                 
Thr Ala Cys Lys Gln Ala Ser Phe His Pro Asp Val Ser Asp Glu Val
625                 630                 635                 640 
Arg Thr Arg Ala Leu Arg Phe Gly Thr Glu Cys Thr Leu Gly Tyr Leu
                645                 650                 655     
Asp Leu Leu Glu His Val Leu Val Ile Leu Gln Lys Pro Thr Pro Glu
            660                 665                 670         
Phe Lys Gln Gln Leu Ala Ala Phe Ser Lys Arg Val Ala Gly Ala Val
        675                 680                 685             
Thr Glu Leu Ile Gln Ala Ala Glu Ala Met Lys Gly Thr Glu Trp Val
    690                 695                 700                 
Asp Pro Glu Asp Pro Thr Val Ile Ala Glu Thr Glu Leu Leu Gly Ala
705                 710                 715                 720 
Ala Ala Ser Ile Glu Ala Ala Ala Lys Lys Leu Glu Gln Leu Lys Pro
                725                 730                 735     
Arg Ala Lys Pro Lys Gln Ala Asp Glu Thr Leu Asp Phe Glu Glu Gln
            740                 745                 750         
Ile Leu Glu Ala Ala Lys Ser Ile Ala Ala Ala Thr Ser Ala Leu Val
        755                 760                 765             
Lys Ser Ala Ser Ala Ala Gln Arg Glu Leu Val Ala Gln Gly Lys Val
    770                 775                 780                 
Gly Ser Ile Pro Ala Asn Ala Ala Asp Asp Gly Gln Trp Ser Gln Gly
785                 790                 795                 800 
Leu Ile Ser Ala Ala Arg Met Val Ala Ala Ala Thr Ser Ser Leu Cys
                805                 810                 815     
Glu Ala Ala Asn Ala Ser Val Gln Gly His Ala Ser Glu Glu Lys Leu
            820                 825                 830         
Ile Ser Ser Ala Lys Gln Val Ala Ala Ser Thr Ala Gln Leu Leu Val
        835                 840                 845             
Ala Cys Lys Val Lys Ala Asp Gln Asp Ser Glu Ala Met Arg Arg Leu
    850                 855                 860                 
Gln Ala Ala Gly Asn Ala Val Lys Arg Ala Ser Asp Asn Leu Val Arg
865                 870                 875                 880 
Ala Ala Gln Lys Ala Ala Phe Gly Lys Ala Asp Asp Asp Asp Val Val
                885                 890                 895     
Val Lys Thr Lys Phe Val Gly Gly Ile Ala Gln Ile Ile Ala Ala Gln
            900                 905                 910         
Glu Glu Met Leu Lys Lys Glu Arg Glu Leu Glu Glu Ala Arg Lys Lys
        915                 920                 925             
Leu Ala Gln Ile Arg Gln Gln Gln Tyr Lys Phe Leu Pro Thr Glu Leu
    930                 935                 940                 
Arg Glu Asp Glu Gly
945                 


<210> 269
<211> 1542
<212> PRT
<213> Homo sapiens

<400> 269
Arg Leu Asn Ser Ser Leu Glu Arg Arg Gly Arg Arg Ile Asp His Val
 1               5                  10                  15      
Leu Leu Asn Ala Asp Gly Ile Arg Gly Phe Pro Val Val Leu Gln Gln
            20                  25                  30          
Ile Ser Lys Ser Leu Asn Tyr Leu Leu Met Ser Ala Ser Gln Thr Lys
        35                  40                  45              
Ser Glu Ser Val Glu Glu Lys Gly Gly Gly Pro Pro Arg Cys Ser Ile
    50                  55                  60                  
Thr Glu Leu Leu Gln Met Cys Trp Pro Ser Leu Ser Glu Asp Cys Val
65                  70                  75                  80  
Ala Ser His Thr Thr Leu Ser Gln Gln Leu Asp Gln Val Leu Gln Ser
                85                  90                  95      
Leu Arg Glu Ala Leu Glu Leu Pro Glu Pro Arg Thr Pro Pro Leu Ser
            100                 105                 110         
Ser Leu Val Glu Gln Ala Ala Gln Lys Ala Pro Glu Ala Glu Ala His
        115                 120                 125             
Pro Val Gln Ile Gln Thr Gln Leu Leu Gln Lys Asn Leu Gly Lys Gln
    130                 135                 140                 
Thr Pro Ser Gly Ser Arg Gln Met Asp Tyr Leu Gly Thr Phe Phe Ser
145                 150                 155                 160 
Tyr Cys Ser Thr Leu Ala Ala Val Leu Leu Gln Ser Leu Ser Ser Glu
                165                 170                 175     
Pro Asp His Val Glu Val Lys Val Gly Asn Pro Phe Val Leu Leu Gln
            180                 185                 190         
Gln Ser Ser Ser Gln Leu Val Ser His Leu Leu Phe Glu Arg Gln Val
        195                 200                 205             
Pro Pro Glu Arg Leu Ala Ala Leu Leu Ala Gln Glu Asn Leu Ser Leu
    210                 215                 220                 
Ser Val Pro Gln Val Ile Val Ser Cys Cys Cys Glu Pro Leu Ala Leu
225                 230                 235                 240 
Cys Ser Ser Arg Gln Ser Gln Gln Thr Ser Ser Leu Leu Thr Arg Leu
                245                 250                 255     
Gly Thr Leu Ala Gln Leu His Ala Ser His Cys Leu Asp Asp Leu Pro
            260                 265                 270         
Leu Ser Thr Pro Ser Ser Pro Arg Thr Thr Glu Asn Pro Thr Leu Glu
        275                 280                 285             
Arg Lys Pro Tyr Ser Ser Pro Arg Asp Ser Ser Leu Pro Ala Leu Thr
    290                 295                 300                 
Ser Ser Ala Leu Ala Phe Leu Lys Ser Arg Ser Lys Leu Leu Ala Thr
305                 310                 315                 320 
Val Ala Cys Leu Gly Ala Ser Pro Arg Leu Lys Val Ser Lys Pro Ser
                325                 330                 335     
Leu Ser Trp Lys Glu Leu Arg Gly Arg Arg Glu Val Pro Leu Ala Ala
            340                 345                 350         
Glu Gln Val Ala Arg Glu Cys Glu Arg Leu Leu Glu Gln Phe Pro Leu
        355                 360                 365             
Phe Glu Ala Phe Leu Leu Ala Ala Trp Glu Pro Leu Arg Gly Ser Leu
    370                 375                 380                 
Gln Gln Gly Gln Ser Leu Ala Val Asn Leu Cys Gly Trp Ala Ser Leu
385                 390                 395                 400 
Ser Thr Val Leu Leu Gly Leu His Ser Pro Ile Ala Leu Asp Val Leu
                405                 410                 415     
Ser Glu Ala Phe Glu Glu Ser Leu Val Ala Arg Asp Trp Ser Arg Ala
            420                 425                 430         
Leu Gln Leu Thr Glu Val Tyr Gly Arg Asp Val Asp Asp Leu Ser Ser
        435                 440                 445             
Ile Lys Asp Ala Val Leu Ser Cys Ala Val Ala Tyr Asp Lys Glu Gly
    450                 455                 460                 
Trp Gln Tyr Leu Phe Pro Val Lys Asp Ala Ser Leu Arg Ser Arg Leu
465                 470                 475                 480 
Ala Leu Gln Phe Val Asp Arg Trp Pro Leu Glu Ser Cys Leu Glu Ile
                485                 490                 495     
Leu Ala Tyr Cys Ile Ser Asp Thr Ala Val Gln Glu Gly Leu Lys Cys
            500                 505                 510         
Glu Leu Gln Arg Lys Leu Ala Glu Leu Gln Val Tyr Gln Lys Ile Leu
        515                 520                 525             
Gly Leu Gln Ser Pro Pro Val Trp Cys Asp Trp Gln Thr Leu Arg Ser
    530                 535                 540                 
Cys Cys Val Glu Asp Pro Ser Thr Val Met Asn Met Ile Leu Glu Ala
545                 550                 555                 560 
Gln Glu Tyr Glu Leu Cys Glu Glu Trp Gly Cys Leu Tyr Pro Ile Pro
                565                 570                 575     
Arg Glu His Leu Ile Ser Leu His Gln Lys His Leu Leu His Leu Leu
            580                 585                 590         
Glu Arg Arg Asp His Asp Lys Ala Leu Gln Leu Leu Arg Arg Ile Pro
        595                 600                 605             
Asp Pro Thr Met Cys Leu Glu Val Thr Glu Gln Ser Leu Asp Gln His
    610                 615                 620                 
Thr Ser Leu Ala Thr Ser His Phe Leu Ala Asn Tyr Leu Thr Thr His
625                 630                 635                 640 
Phe Tyr Gly Gln Leu Thr Ala Val Arg His Arg Glu Ile Gln Ala Leu
                645                 650                 655     
Tyr Val Gly Ser Lys Ile Leu Leu Thr Leu Pro Glu Gln His Arg Ala
            660                 665                 670         
Ser Tyr Ser His Leu Ser Ser Asn Pro Leu Phe Met Leu Glu Gln Leu
        675                 680                 685             
Leu Met Asn Met Lys Val Asp Trp Ala Thr Val Ala Val Gln Thr Leu
    690                 695                 700                 
Gln Gln Leu Leu Val Gly Gln Glu Ile Gly Phe Thr Met Asp Glu Val
705                 710                 715                 720 
Asp Ser Leu Leu Ser Arg Tyr Ala Glu Lys Ala Leu Asp Phe Pro Tyr
                725                 730                 735     
Pro Gln Arg Glu Lys Arg Ser Asp Ser Val Ile His Leu Gln Glu Ile
            740                 745                 750         
Val His Gln Ala Ala Asp Pro Glu Thr Leu Pro Arg Ser Pro Ser Ala
        755                 760                 765             
Glu Phe Ser Pro Ala Ala Pro Pro Gly Ile Ser Ser Ile His Ser Pro
    770                 775                 780                 
Ser Leu Arg Glu Arg Ser Phe Pro Pro Thr Gln Pro Ser Gln Glu Phe
785                 790                 795                 800 
Val Pro Pro Ala Thr Pro Pro Ala Arg His Gln Trp Val Pro Asp Glu
                805                 810                 815     
Thr Glu Ser Ile Cys Met Val Cys Cys Arg Glu His Phe Thr Met Phe
            820                 825                 830         
Asn Arg Arg His His Cys Arg Arg Cys Gly Arg Leu Val Cys Ser Ser
        835                 840                 845             
Cys Ser Thr Lys Lys Met Val Val Glu Gly Cys Arg Glu Asn Pro Ala
    850                 855                 860                 
Arg Val Cys Asp Gln Cys Tyr Ser Tyr Cys Asn Lys Asp Val Pro Glu
865                 870                 875                 880 
Glu Pro Ser Glu Lys Pro Glu Ala Leu Asp Ser Ser Lys Ser Glu Ser
                885                 890                 895     
Pro Pro Tyr Ser Phe Val Val Arg Val Pro Lys Ala Asp Glu Val Glu
            900                 905                 910         
Trp Ile Leu Asp Leu Lys Glu Glu Glu Asn Glu Leu Val Arg Ser Glu
        915                 920                 925             
Phe Tyr Tyr Glu Gln Ala Pro Ser Ala Ser Leu Cys Ile Ala Ile Leu
    930                 935                 940                 
Asn Leu His Arg Asp Ser Ile Ala Cys Gly His Gln Leu Ile Glu His
945                 950                 955                 960 
Cys Cys Arg Leu Ser Lys Gly Leu Thr Asn Pro Glu Val Asp Ala Gly
                965                 970                 975     
Leu Leu Thr Asp Ile Met Lys Gln Leu Leu Phe Ser Ala Lys Met Met
            980                 985                 990         
Phe Val Lys Ala Gly Gln Ser Gln Asp Leu Ala Leu Cys Asp Ser Tyr
        995                 1000                1005            
Ile Ser Lys Val Asp Val Leu Asn Ile Leu Val Ala Ala Ala Tyr Arg
    1010                1015                1020                
His Val Pro Ser Leu Asp Gln Ile Leu Gln Pro Ala Ala Val Thr Arg
1025                1030                1035                1040
Leu Arg Asn Gln Leu Leu Glu Ala Glu Tyr Tyr Gln Leu Gly Val Glu
                1045                1050                1055    
Val Ser Thr Lys Thr Gly Leu Asp Thr Thr Gly Ala Trp His Ala Trp
            1060                1065                1070        
Gly Met Ala Cys Leu Lys Ala Gly Asn Leu Thr Ala Ala Arg Glu Lys
        1075                1080                1085            
Phe Ser Arg Cys Leu Lys Pro Pro Phe Asp Leu Asn Gln Leu Asn His
    1090                1095                1100                
Gly Ser Arg Leu Val Gln Asp Val Val Glu Tyr Leu Glu Ser Thr Val
1105                1110                1115                1120
Arg Pro Phe Val Ser Leu Gln Asp Asp Asp Tyr Phe Ala Thr Leu Arg
                1125                1130                1135    
Glu Leu Glu Ala Thr Leu Arg Thr Gln Ser Leu Ser Leu Ala Val Ile
            1140                1145                1150        
Pro Glu Gly Lys Ile Met Asn Asn Thr Tyr Tyr Gln Glu Cys Leu Phe
        1155                1160                1165            
Tyr Leu His Asn Tyr Ser Thr Asn Leu Ala Ile Ile Ser Phe Tyr Val
    1170                1175                1180                
Arg His Ser Cys Leu Arg Glu Ala Leu Leu His Leu Leu Asn Lys Glu
1185                1190                1195                1200
Ser Pro Pro Glu Val Phe Ile Glu Gly Ile Phe Gln Pro Ser Tyr Lys
                1205                1210                1215    
Ser Gly Lys Leu His Thr Leu Glu Asn Leu Leu Glu Ser Ile Asp Pro
            1220                1225                1230        
Thr Leu Glu Ser Trp Gly Lys Tyr Leu Ile Ala Ala Cys Gln His Leu
        1235                1240                1245            
Gln Lys Lys Asn Tyr Tyr His Ile Leu Tyr Glu Leu Gln Gln Phe Met
    1250                1255                1260                
Lys Asp Gln Val Arg Ala Ala Met Thr Cys Ile Arg Phe Phe Ser His
1265                1270                1275                1280
Lys Ala Lys Ser Tyr Thr Glu Leu Gly Glu Lys Leu Ser Trp Leu Leu
                1285                1290                1295    
Lys Ala Lys Asp His Leu Lys Ile Tyr Leu Gln Glu Thr Ser Arg Ser
            1300                1305                1310        
Ser Gly Arg Lys Lys Thr Thr Phe Phe Arg Lys Lys Met Thr Ala Ala
        1315                1320                1325            
Asp Val Ser Arg His Met Asn Thr Leu Gln Leu Gln Met Glu Val Thr
    1330                1335                1340                
Arg Phe Leu His Arg Cys Glu Ser Ala Gly Thr Ser Gln Ile Thr Thr
1345                1350                1355                1360
Leu Pro Leu Pro Thr Leu Phe Gly Asn Asn His Met Lys Met Asp Val
                1365                1370                1375    
Ala Cys Lys Val Met Leu Gly Gly Lys Asn Val Glu Asp Gly Phe Gly
            1380                1385                1390        
Ile Ala Phe Arg Val Leu Gln Asp Phe Gln Leu Asp Ala Ala Met Thr
        1395                1400                1405            
Tyr Cys Arg Ala Ala Arg Gln Leu Val Glu Lys Glu Lys Tyr Ser Glu
    1410                1415                1420                
Ile Gln Gln Leu Leu Lys Cys Val Ser Glu Ser Gly Met Ala Ala Lys
1425                1430                1435                1440
Ser Asp Gly Asp Thr Ile Leu Leu Asn Cys Leu Glu Ala Phe Lys Arg
                1445                1450                1455    
Ile Pro Pro Gln Glu Leu Glu Gly Leu Ile Gln Ala Ile His Asn Asp
            1460                1465                1470        
Asp Asn Lys Val Arg Ala Tyr Leu Ile Cys Cys Lys Leu Arg Ser Ala
        1475                1480                1485            
Tyr Leu Ile Ala Val Lys Gln Glu His Ser Arg Ala Thr Ala Leu Val
    1490                1495                1500                
Gln Gln Val Gln Gln Ala Ala Lys Ser Ser Gly Asp Ala Val Val Gln
1505                1510                1515                1520
Asp Ile Cys Ala Gln Trp Leu Leu Thr Ser His Pro Arg Gly Ala His
                1525                1530                1535    
Gly Pro Gly Ser Arg Lys
            1540        


<210> 270
<211> 1053
<212> PRT
<213> Homo sapiens

<400> 270
Gly Ala Gln Leu Leu Gly Val His Pro Lys Gly Glu Ser Gln Arg Ala
 1               5                  10                  15      
Ser Arg Gly Gly Gly Gln Ala Thr Lys Met Ser Ser Ala Val Gly Pro
            20                  25                  30          
Arg Gly Pro Arg Pro Pro Thr Val Pro Pro Pro Met Gln Glu Leu Pro
        35                  40                  45              
Asp Leu Ser His Leu Thr Glu Glu Glu Arg Asn Ile Ile Met Ala Val
    50                  55                  60                  
Met Asp Arg Gln Lys Glu Glu Glu Glu Lys Glu Glu Ala Met Leu Lys
65                  70                  75                  80  
Cys Val Val Arg Asp Met Ala Lys Pro Ala Ala Cys Lys Thr Pro Arg
                85                  90                  95      
Asn Ala Glu Asn Gln Pro His Gln Pro Ser Pro Arg Leu His Gln Gln
            100                 105                 110         
Phe Glu Ser Tyr Lys Glu Gln Val Arg Lys Ile Gly Glu Glu Ala Arg
        115                 120                 125             
Arg Tyr Gln Gly Glu His Lys Asp Asp Ala Pro Thr Cys Gly Ile Cys
    130                 135                 140                 
His Lys Thr Lys Phe Ala Asp Gly Cys Gly His Leu Cys Ser Tyr Cys
145                 150                 155                 160 
Arg Thr Lys Phe Cys Ala Arg Cys Gly Gly Arg Val Ser Leu Arg Ser
                165                 170                 175     
Asn Asn Glu Asp Lys Val Val Met Trp Val Cys Asn Leu Cys Arg Lys
            180                 185                 190         
Gln Gln Glu Ile Leu Thr Lys Ser Gly Ala Trp Phe Phe Gly Ser Gly
        195                 200                 205             
Pro Gln Gln Thr Ser Gln Asp Gly Thr Leu Ser Asp Thr Ala Thr Gly
    210                 215                 220                 
Ala Gly Ser Glu Val Pro Arg Glu Lys Lys Ala Arg Leu Gln Glu Arg
225                 230                 235                 240 
Ser Arg Ser Gln Thr Pro Leu Ser Thr Ala Ala Ala Ser Ser Gln Asp
                245                 250                 255     
Ala Ala Pro Pro Ser Ala Pro Pro Asp Arg Ser Lys Gly Ala Glu Pro
            260                 265                 270         
Ser Gln Gln Ala Leu Gly Pro Glu Gln Lys Gln Ala Ser Ser Arg Ser
        275                 280                 285             
Arg Ser Glu Pro Pro Arg Glu Arg Lys Lys Thr Pro Gly Leu Ser Glu
    290                 295                 300                 
Gln Asn Gly Lys Gly Ala Leu Lys Ser Glu Arg Lys Arg Val Pro Lys
305                 310                 315                 320 
Thr Ser Ala Gln Pro Val Glu Gly Ala Val Glu Glu Arg Glu Arg Lys
                325                 330                 335     
Glu Arg Arg Glu Ser Arg Arg Leu Glu Lys Gly Arg Ser Gln Asp Tyr
            340                 345                 350         
Pro Asp Thr Pro Glu Lys Arg Asp Glu Gly Lys Ala Ala Asp Glu Glu
        355                 360                 365             
Lys Gln Arg Lys Glu Glu Asp Tyr Gln Thr Arg Tyr Arg Ser Asp Pro
    370                 375                 380                 
Asn Leu Ala Arg Tyr Pro Val Lys Pro Pro Pro Glu Glu Gln Gln Met
385                 390                 395                 400 
Arg Met His Ala Arg Val Ser Arg Ala Arg His Glu Arg Arg His Ser
                405                 410                 415     
Asp Val Ala Leu Pro Arg Thr Glu Ala Gly Ala Ala Leu Pro Glu Gly
            420                 425                 430         
Lys Ala Gly Lys Arg Ala Pro Ala Ala Ala Arg Ala Ser Pro Pro Asp
        435                 440                 445             
Ser Pro Arg Ala Tyr Ser Ala Glu Arg Thr Ala Glu Thr Arg Ala Pro
    450                 455                 460                 
Gly Ala Lys Gln Leu Thr Asn His Ser Pro Pro Ala Pro Arg His Gly
465                 470                 475                 480 
Pro Val Pro Ala Glu Ala Pro Glu Leu Lys Ala Gln Glu Pro Leu Arg
                485                 490                 495     
Lys Gln Ser Arg Leu Asp Pro Ser Ser Ala Val Leu Met Leu Arg Asn
            500                 505                 510         
Asp Ser Leu Ser Ser Asp Gln Ser Glu Ser Val Arg Pro Ser Pro Pro
        515                 520                 525             
Lys Pro His Arg Ser Lys Arg Gly Gly Lys Lys Arg Gln Met Ser Val
    530                 535                 540                 
Ser Ser Ser Glu Glu Glu Gly Val Ser Thr Pro Glu Tyr Thr Ser Cys
545                 550                 555                 560 
Glu Asp Val Glu Leu Glu Ser Glu Ser Val Ser Glu Lys Gly Asp Leu
                565                 570                 575     
Asp Tyr Tyr Trp Leu Asp Pro Ala Thr Trp His Ser Arg Glu Thr Ser
            580                 585                 590         
Pro Ile Ser Ser His Pro Val Thr Trp Gln Pro Ser Lys Glu Gly Asp
        595                 600                 605             
Arg Leu Ile Gly Arg Val Ile Leu Asn Lys Arg Thr Thr Met Pro Lys
    610                 615                 620                 
Asp Ser Gly Ala Leu Leu Gly Leu Lys Val Val Gly Gly Lys Met Thr
625                 630                 635                 640 
Asp Leu Gly Arg Leu Gly Ala Phe Ile Thr Lys Val Lys Lys Gly Ser
                645                 650                 655     
Leu Ala Asp Val Val Gly His Leu Arg Ala Gly Asp Glu Val Leu Glu
            660                 665                 670         
Trp Asn Gly Lys Pro Leu Pro Gly Ala Thr Asn Glu Glu Val Tyr Asn
        675                 680                 685             
Ile Ile Leu Glu Ser Lys Ser Glu Pro Gln Val Glu Ile Ile Val Ser
    690                 695                 700                 
Arg Pro Ile Gly Asp Ile Pro Arg Ile Pro Glu Ser Ser His Pro Pro
705                 710                 715                 720 
Leu Glu Ser Ser Ser Ser Ser Phe Glu Ser Gln Lys Met Glu Arg Pro
                725                 730                 735     
Ser Ile Ser Val Ile Ser Pro Thr Ser Pro Gly Ala Leu Lys Asp Ala
            740                 745                 750         
Pro Gln Val Leu Pro Gly Gln Leu Ser Val Lys Leu Trp Tyr Asp Lys
        755                 760                 765             
Val Gly His Gln Leu Ile Val Asn Val Leu Gln Ala Thr Asp Leu Pro
    770                 775                 780                 
Ala Arg Val Asp Gly Arg Pro Arg Asn Pro Tyr Val Lys Met Tyr Phe
785                 790                 795                 800 
Leu Pro Asp Arg Ser Asp Lys Ser Lys Arg Arg Thr Lys Thr Val Lys
                805                 810                 815     
Lys Ile Leu Glu Pro Lys Trp Asn Gln Thr Phe Val Tyr Ser His Val
            820                 825                 830         
His Arg Arg Asp Phe Arg Glu Arg Met Leu Glu Ile Thr Val Trp Asp
        835                 840                 845             
Gln Pro Arg Val Gln Glu Glu Glu Ser Glu Phe Leu Gly Glu Ile Leu
    850                 855                 860                 
Ile Glu Leu Glu Thr Ala Leu Leu Asp Asp Glu Pro His Trp Tyr Lys
865                 870                 875                 880 
Leu Gln Thr His Asp Glu Ser Ser Leu Pro Leu Pro Gln Pro Ser Pro
                885                 890                 895     
Phe Met Pro Arg Arg His Ile His Gly Glu Ser Ser Ser Lys Lys Leu
            900                 905                 910         
Gln Arg Ser Gln Arg Ile Ser Asp Ser Asp Ile Ser Asp Tyr Glu Val
        915                 920                 925             
Asp Asp Gly Ile Gly Val Val Pro Pro Val Gly Tyr Arg Ser Ser Ala
    930                 935                 940                 
Arg Glu Ser Lys Ser Thr Thr Leu Thr Val Pro Glu Gln Gln Arg Thr
945                 950                 955                 960 
Thr His His Arg Ser Arg Ser Val Ser Pro His Arg Gly Asn Asp Gln
                965                 970                 975     
Gly Lys Pro Arg Ser Arg Leu Pro Asn Val Pro Leu Gln Arg Ser Leu
            980                 985                 990         
Asp Glu Ile His Pro Thr Arg Arg Ser Arg Ser Pro Thr Arg His His
        995                 1000                1005            
Asp Ala Ser Arg Ser Pro Val Asp His Arg Thr Arg Asp Val Asp Ser
    1010                1015                1020                
Gln Tyr Leu Ser Glu Gln Asp Ser Glu Leu Leu Met Leu Pro Arg Ala
1025                1030                1035                1040
Lys Arg Gly Arg Ser Ala Glu Cys Leu His Thr Thr Arg
                1045                1050            


<210> 271
<211> 1371
<212> PRT
<213> Homo sapiens

<400> 271
Ala Ala Ser Ala Ser Ser Thr Asn Leu Ile His Leu Ser Ser Lys Gly
 1               5                  10                  15      
His Ile Ser Pro Ala Lys Asp Thr Ser Leu Gln Gln Arg Thr Pro Ala
            20                  25                  30          
Glu Met Ser Pro Val Leu His Phe Tyr Val Arg Pro Ser Gly His Glu
        35                  40                  45              
Gly Ala Ala Ser Gly His Thr Arg Arg Lys Leu Gln Gly Lys Leu Pro
    50                  55                  60                  
Glu Leu Gln Gly Val Glu Thr Glu Leu Cys Tyr Asn Val Asn Trp Thr
65                  70                  75                  80  
Ala Glu Ala Leu Pro Ser Ala Glu Glu Thr Lys Lys Leu Met Trp Leu
                85                  90                  95      
Phe Gly Cys Pro Leu Leu Leu Asp Asp Val Ala Arg Glu Ser Trp Leu
            100                 105                 110         
Leu Pro Gly Ser Asn Asp Leu Leu Leu Glu Val Gly Pro Arg Leu Asn
        115                 120                 125             
Phe Ser Thr Pro Thr Ser Thr Asn Ile Val Ser Val Cys Arg Ala Thr
    130                 135                 140                 
Gly Leu Gly Pro Val Asp Arg Val Glu Thr Thr Arg Arg Tyr Arg Leu
145                 150                 155                 160 
Ser Phe Ala His Pro Pro Ser Ala Glu Val Glu Ala Ile Ala Leu Ala
                165                 170                 175     
Thr Leu His Asp Arg Met Thr Glu Gln His Phe Pro His Pro Ile Gln
            180                 185                 190         
Ser Phe Ser Pro Glu Ser Met Pro Glu Pro Leu Asn Gly Pro Ile Asn
        195                 200                 205             
Ile Leu Gly Glu Gly Arg Leu Ala Leu Glu Lys Ala Asn Gln Glu Leu
    210                 215                 220                 
Gly Leu Ala Leu Asp Ser Trp Asp Leu Asp Phe Tyr Thr Lys Arg Phe
225                 230                 235                 240 
Gln Glu Leu Gln Arg Asn Pro Ser Thr Val Glu Ala Phe Asp Leu Ala
                245                 250                 255     
Gln Ser Asn Ser Glu His Ser Arg His Trp Phe Phe Lys Gly Gln Leu
            260                 265                 270         
His Val Asp Gly Gln Lys Leu Val His Ser Leu Phe Glu Ser Ile Met
        275                 280                 285             
Ser Thr Gln Glu Ser Ser Asn Pro Asn Asn Val Leu Lys Phe Cys Asp
    290                 295                 300                 
Asn Ser Ser Ala Ile Gln Gly Lys Glu Val Arg Phe Leu Arg Pro Glu
305                 310                 315                 320 
Asp Pro Thr Arg Pro Ser Arg Phe Gln Gln Gln Gln Gly Leu Arg His
                325                 330                 335     
Val Val Phe Thr Ala Glu Thr His Asn Phe Pro Thr Gly Val Cys Pro
            340                 345                 350         
Phe Ser Gly Ala Thr Thr Gly Thr Gly Gly Arg Ile Arg Asp Val Gln
        355                 360                 365             
Cys Thr Gly Arg Gly Ala His Val Val Ala Gly Thr Ala Gly Tyr Cys
    370                 375                 380                 
Phe Gly Asn Leu His Ile Pro Gly Tyr Asn Leu Pro Trp Glu Asp Leu
385                 390                 395                 400 
Ser Phe Gln Tyr Pro Gly Asn Phe Ala Arg Pro Leu Glu Val Ala Ile
                405                 410                 415     
Glu Ala Ser Asn Gly Ala Ser Asp Tyr Gly Asn Lys Phe Gly Glu Pro
            420                 425                 430         
Val Leu Ala Gly Phe Ala Arg Ser Leu Gly Leu Gln Leu Pro Asp Gly
        435                 440                 445             
Gln Arg Arg Glu Trp Ile Lys Pro Ile Met Phe Ser Gly Gly Ile Gly
    450                 455                 460                 
Ser Met Glu Ala Asp His Ile Ser Lys Glu Ala Pro Glu Pro Gly Met
465                 470                 475                 480 
Glu Val Val Lys Val Gly Gly Pro Val Tyr Arg Ile Gly Val Gly Gly
                485                 490                 495     
Gly Ala Ala Ser Ser Val Gln Val Gln Gly Asp Asn Thr Ser Asp Leu
            500                 505                 510         
Asp Phe Gly Ala Val Gln Arg Gly Asp Pro Glu Met Glu Gln Lys Met
        515                 520                 525             
Asn Arg Val Ile Arg Ala Cys Val Glu Ala Pro Lys Gly Asn Pro Ile
    530                 535                 540                 
Cys Ser Leu His Asp Gln Gly Ala Gly Gly Asn Gly Asn Val Leu Lys
545                 550                 555                 560 
Glu Leu Ser Asp Pro Ala Gly Ala Ile Ile Tyr Thr Ser Arg Phe Gln
                565                 570                 575     
Leu Gly Asp Pro Thr Leu Asn Ala Leu Glu Ile Trp Gly Ala Glu Tyr
            580                 585                 590         
Gln Glu Ser Asn Ala Leu Leu Leu Arg Ser Pro Asn Arg Asp Phe Leu
        595                 600                 605             
Thr His Val Ser Ala Arg Glu Arg Cys Pro Ala Cys Phe Val Gly Thr
    610                 615                 620                 
Ile Thr Gly Asp Arg Arg Ile Val Leu Val Asp Asp Arg Glu Cys Pro
625                 630                 635                 640 
Val Arg Arg Asn Gly Gln Gly Asp Ala Pro Pro Thr Pro Pro Pro Thr
                645                 650                 655     
Pro Val Asp Leu Glu Leu Glu Trp Val Leu Gly Lys Met Pro Arg Lys
            660                 665                 670         
Glu Phe Phe Leu Gln Arg Lys Pro Pro Met Leu Gln Pro Leu Ala Leu
        675                 680                 685             
Pro Pro Gly Leu Ser Val His Gln Ala Leu Glu Arg Val Leu Arg Leu
    690                 695                 700                 
Pro Ala Val Ala Ser Lys Arg Tyr Leu Thr Asn Lys Val Asp Arg Ser
705                 710                 715                 720 
Val Gly Gly Leu Val Ala Gln Gln Gln Cys Val Gly Pro Leu Gln Thr
                725                 730                 735     
Pro Leu Ala Asp Val Ala Val Val Ala Leu Ser His Glu Glu Leu Ile
            740                 745                 750         
Gly Ala Ala Thr Ala Leu Gly Glu Gln Pro Val Lys Ser Leu Leu Asp
        755                 760                 765             
Pro Lys Val Ala Ala Arg Leu Ala Val Ala Glu Ala Leu Thr Asn Leu
    770                 775                 780                 
Val Phe Ala Leu Val Thr Asp Leu Arg Asp Val Lys Cys Ser Gly Asn
785                 790                 795                 800 
Trp Met Trp Ala Ala Lys Leu Pro Gly Glu Gly Ala Ala Leu Ala Asp
                805                 810                 815     
Ala Cys Glu Ala Met Val Ala Val Met Ala Ala Leu Gly Val Ala Val
            820                 825                 830         
Asp Gly Gly Lys Asp Ser Leu Ser Met Ala Ala Arg Val Gly Thr Glu
        835                 840                 845             
Thr Val Arg Ala Pro Gly Ser Leu Val Ile Ser Ala Tyr Ala Val Cys
    850                 855                 860                 
Pro Asp Ile Thr Ala Thr Val Thr Pro Asp Leu Lys His Pro Glu Gly
865                 870                 875                 880 
Arg Gly His Leu Leu Tyr Val Ala Leu Ser Pro Gly Gln His Arg Leu
                885                 890                 895     
Gly Gly Thr Ala Leu Ala Gln Cys Phe Ser Gln Leu Gly Glu His Pro
            900                 905                 910         
Pro Asp Leu Asp Leu Pro Glu Asn Leu Val Arg Ala Phe Ser Ile Thr
        915                 920                 925             
Gln Gly Leu Leu Lys Asp Arg Leu Leu Cys Ser Gly His Asp Val Ser
    930                 935                 940                 
Asp Gly Gly Leu Val Thr Cys Leu Leu Glu Met Ala Phe Ala Gly Asn
945                 950                 955                 960 
Cys Gly Leu Gln Val Asp Val Pro Val Pro Arg Val Asp Val Leu Ser
                965                 970                 975     
Val Leu Phe Ala Glu Glu Pro Gly Leu Val Leu Glu Val Gln Glu Pro
            980                 985                 990         
Asp Leu Ala Gln Val Leu Lys Arg Tyr Arg Asp Ala Gly Leu His Cys
        995                 1000                1005            
Leu Glu Leu Gly His Thr Gly Glu Ala Gly Pro His Ala Met Val Arg
    1010                1015                1020                
Val Ser Val Asn Gly Ala Val Val Leu Glu Glu Pro Val Gly Glu Leu
1025                1030                1035                1040
Arg Ala Leu Trp Glu Glu Thr Ser Phe Gln Leu Asp Arg Leu Gln Ala
                1045                1050                1055    
Glu Pro Arg Cys Val Ala Glu Glu Glu Arg Gly Leu Arg Glu Arg Met
            1060                1065                1070        
Gly Pro Ser Tyr Cys Leu Pro Pro Thr Phe Pro Lys Ala Ser Val Pro
        1075                1080                1085            
Arg Glu Pro Gly Gly Pro Ser Pro Arg Val Ala Ile Leu Arg Glu Glu
    1090                1095                1100                
Gly Ser Asn Gly Asp Arg Glu Met Ala Asp Ala Phe His Leu Ala Gly
1105                1110                1115                1120
Phe Glu Val Trp Asp Val Thr Met Gln Asp Leu Cys Ser Gly Ala Ile
                1125                1130                1135    
Gly Leu Asp Thr Phe Arg Gly Val Ala Phe Val Gly Gly Phe Ser Tyr
            1140                1145                1150        
Ala Asp Val Leu Gly Ser Ala Lys Gly Trp Ala Ala Ala Val Thr Phe
        1155                1160                1165            
His Pro Arg Ala Gly Ala Glu Leu Arg Arg Phe Arg Lys Arg Pro Asp
    1170                1175                1180                
Thr Phe Ser Leu Gly Val Cys Asn Gly Cys Gln Leu Leu Ala Leu Leu
1185                1190                1195                1200
Gly Trp Val Gly Gly Asp Pro Asn Glu Asp Ala Ala Glu Met Gly Pro
                1205                1210                1215    
Asp Ser Gln Pro Ala Arg Pro Gly Leu Leu Leu Arg His Asn Leu Ser
            1220                1225                1230        
Gly Arg Tyr Glu Ser Arg Trp Ala Ser Val Arg Val Gly Pro Gly Pro
        1235                1240                1245            
Ala Leu Met Leu Arg Gly Met Glu Gly Ala Val Leu Pro Val Trp Ser
    1250                1255                1260                
Ala His Gly Glu Gly Tyr Val Ala Phe Ser Ser Pro Glu Leu Gln Ala
1265                1270                1275                1280
Gln Ile Glu Ala Arg Gly Leu Ala Pro Leu His Trp Ala Asp Asp Asp
                1285                1290                1295    
Gly Asn Pro Thr Glu Gln Tyr Pro Leu Asn Pro Asn Gly Ser Pro Gly
            1300                1305                1310        
Gly Val Ala Gly Ile Cys Ser Cys Asp Gly Arg His Leu Ala Val Met
        1315                1320                1325            
Pro His Pro Glu Arg Ala Val Arg Pro Trp Gln Trp Ala Trp Arg Pro
    1330                1335                1340                
Pro Pro Phe Asp Thr Leu Thr Thr Ser Pro Trp Leu Gln Leu Ser Ile
1345                1350                1355                1360
Asn Ala Arg Asn Trp Thr Leu Glu Gly Ser Cys
                1365                1370    


<210> 272
<211> 31
<212> PRT
<213> Homo sapiens

<400> 272
Ser Thr Phe Ala Val Asp Gly Lys Asp Cys Lys Val Asn Lys Glu Val
 1               5                  10                  15      
Glu Arg Val Leu Lys Glu Phe His Gln Ala Gly Lys Pro Ile Gly
            20                  25                  30      


<210> 273
<211> 266
<212> PRT
<213> Homo sapiens

<400> 273
Ala Cys Ile Ser Phe Gly Pro Lys Asn Arg Ser Ile Gly Ala Ala Ala
 1               5                  10                  15      
Lys Ser Gln Val Ile Ser Asn Ala Lys Asn Thr Val Gln Gly Phe Lys
            20                  25                  30          
Arg Phe His Gly Arg Ala Phe Ser Asp Pro Phe Val Glu Ala Glu Lys
        35                  40                  45              
Ser Asn Leu Ala Tyr Asp Ile Val Gln Leu Pro Thr Gly Leu Thr Gly
    50                  55                  60                  
Ile Lys Val Thr Tyr Met Glu Glu Glu Arg Asn Phe Thr Thr Glu Gln
65                  70                  75                  80  
Val Thr Ala Met Leu Leu Ser Lys Leu Lys Glu Thr Ala Glu Ser Val
                85                  90                  95      
Leu Lys Lys Pro Val Val Asp Cys Val Val Ser Val Pro Cys Phe Tyr
            100                 105                 110         
Thr Asp Ala Glu Arg Arg Ser Val Met Asp Ala Thr Gln Ile Ala Gly
        115                 120                 125             
Leu Asn Cys Leu Arg Leu Met Asn Glu Thr Thr Ala Val Ala Leu Ala
    130                 135                 140                 
Tyr Gly Ile Tyr Lys Gln Asp Leu Pro Ala Leu Glu Glu Lys Pro Arg
145                 150                 155                 160 
Asn Val Val Phe Val Asp Met Gly His Ser Ala Tyr Gln Val Ser Val
                165                 170                 175     
Cys Ala Phe Asn Arg Gly Lys Leu Lys Val Leu Ala Thr Ala Phe Asp
            180                 185                 190         
Thr Thr Leu Gly Gly Arg Lys Phe Asp Glu Val Leu Val Asn His Phe
        195                 200                 205             
Cys Glu Glu Phe Gly Lys Lys Tyr Lys Leu Asp Ile Lys Ser Lys Ile
    210                 215                 220                 
Arg Ala Leu Leu Arg Leu Ser Gln Glu Cys Glu Lys Leu Lys Lys Leu
225                 230                 235                 240 
Met Ser Ala Asn Ala Ser Asp Leu Pro Leu Ser Ile Glu Cys Phe Met
                245                 250                 255     
Asn Asp Val Asp Val Ser Gly Thr Met Asn
            260                 265     


<210> 274
<211> 1805
<212> PRT
<213> Homo sapiens

<400> 274
Met Ala Gly Pro Arg Pro Ser Pro Trp Ala Arg Leu Leu Leu Ala Ala
 1               5                  10                  15      
Leu Ile Ser Val Ser Leu Ser Gly Thr Leu Ala Asn Arg Cys Lys Lys
            20                  25                  30          
Ala Pro Val Lys Ser Cys Thr Glu Cys Val Arg Val Asp Lys Asp Cys
        35                  40                  45              
Ala Tyr Cys Thr Asp Glu Met Phe Arg Asp Arg Arg Cys Asn Thr Gln
    50                  55                  60                  
Ala Glu Leu Leu Ala Ala Gly Cys Gln Arg Glu Ser Ile Val Val Met
65                  70                  75                  80  
Glu Ser Ser Phe Gln Ile Thr Glu Glu Thr Gln Ile Asp Thr Thr Leu
                85                  90                  95      
Arg Arg Ser Gln Met Ser Pro Gln Gly Leu Arg Val Arg Leu Arg Pro
            100                 105                 110         
Gly Glu Glu Arg His Phe Glu Leu Glu Val Phe Glu Pro Leu Glu Ser
        115                 120                 125             
Pro Val Asp Leu Tyr Ile Leu Met Asp Phe Ser Asn Ser Met Ser Asp
    130                 135                 140                 
Asp Leu Asp Asn Leu Lys Lys Met Gly Gln Asn Leu Ala Arg Val Leu
145                 150                 155                 160 
Ser Gln Leu Thr Ser Asp Tyr Thr Ile Gly Phe Gly Lys Phe Val Asp
                165                 170                 175     
Lys Val Ser Val Pro Gln Thr Asp Met Arg Pro Glu Lys Leu Lys Glu
            180                 185                 190         
Pro Trp Pro Asn Ser Asp Pro Pro Phe Ser Phe Lys Asn Val Ile Ser
        195                 200                 205             
Leu Thr Glu Asp Val Asp Glu Phe Arg Asn Lys Leu Gln Gly Glu Arg
    210                 215                 220                 
Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Phe Asp Ala Ile Leu
225                 230                 235                 240 
Gln Thr Ala Val Cys Thr Arg Asp Ile Gly Trp Arg Pro Asp Ser Thr
                245                 250                 255     
His Leu Leu Val Phe Ser Thr Glu Ser Ala Phe His Tyr Glu Ala Asp
            260                 265                 270         
Gly Ala Asn Val Leu Ala Gly Ile Met Ser Arg Asn Asp Glu Arg Cys
        275                 280                 285             
His Leu Asp Thr Thr Gly Thr Tyr Thr Gln Tyr Arg Thr Gln Asp Tyr
    290                 295                 300                 
Pro Ser Val Pro Thr Leu Val Arg Leu Leu Ala Lys His Asn Ile Ile
305                 310                 315                 320 
Pro Ile Phe Ala Val Thr Asn Tyr Ser Tyr Ser Tyr Tyr Glu Lys Leu
                325                 330                 335     
His Thr Tyr Phe Pro Val Ser Ser Leu Gly Val Leu Gln Glu Asp Ser
            340                 345                 350         
Ser Asn Ile Val Glu Leu Leu Glu Glu Ala Phe Asn Arg Ile Arg Ser
        355                 360                 365             
Asn Leu Asp Ile Arg Ala Leu Asp Ser Pro Arg Gly Leu Arg Thr Glu
    370                 375                 380                 
Val Thr Ser Lys Met Phe Gln Lys Thr Arg Thr Gly Ser Phe His Ile
385                 390                 395                 400 
Arg Arg Gly Glu Val Gly Ile Tyr Gln Val Gln Leu Arg Ala Leu Glu
                405                 410                 415     
His Val Asp Gly Thr His Val Cys Gln Leu Pro Glu Asp Gln Lys Gly
            420                 425                 430         
Asn Ile His Leu Lys Pro Ser Phe Ser Asp Gly Leu Lys Met Asp Ala
        435                 440                 445             
Gly Ile Ile Cys Asp Val Cys Thr Cys Glu Leu Gln Lys Glu Val Arg
    450                 455                 460                 
Ser Ala Arg Cys Ser Phe Asn Gly Asp Phe Val Cys Gly Gln Cys Val
465                 470                 475                 480 
Cys Ser Glu Gly Trp Ser Gly Gln Thr Cys Asn Cys Ser Thr Gly Ser
                485                 490                 495     
Leu Ser Asp Ile Gln Pro Cys Leu Arg Glu Gly Glu Asp Lys Pro Cys
            500                 505                 510         
Ser Gly Arg Gly Glu Cys Gln Cys Gly His Cys Val Cys Tyr Gly Glu
        515                 520                 525             
Gly Arg Tyr Glu Gly Gln Phe Cys Glu Tyr Asp Asn Phe Gln Cys Pro
    530                 535                 540                 
Arg Thr Ser Gly Phe Leu Cys Asn Asp Arg Gly Arg Cys Ser Met Gly
545                 550                 555                 560 
Gln Cys Val Cys Glu Pro Gly Trp Thr Gly Pro Ser Cys Asp Cys Pro
                565                 570                 575     
Leu Ser Asn Ala Thr Cys Ile Asp Ser Asn Gly Gly Ile Cys Asn Gly
            580                 585                 590         
Arg Gly His Cys Glu Cys Gly Arg Cys His Cys His Gln Gln Ser Leu
        595                 600                 605             
Tyr Thr Asp Thr Ile Cys Glu Ile Asn Tyr Ser Ala Ile His Pro Gly
    610                 615                 620                 
Leu Cys Glu Asp Leu Arg Ser Cys Val Gln Cys Gln Ala Trp Gly Thr
625                 630                 635                 640 
Gly Glu Lys Lys Gly Arg Thr Cys Glu Glu Cys Asn Phe Lys Val Lys
                645                 650                 655     
Met Val Asp Glu Leu Lys Arg Ala Glu Glu Val Val Val Arg Cys Ser
            660                 665                 670         
Phe Arg Asp Glu Asp Asp Asp Cys Thr Tyr Ser Tyr Thr Met Glu Gly
        675                 680                 685             
Asp Gly Ala Pro Gly Pro Asn Ser Thr Val Leu Val His Lys Lys Lys
    690                 695                 700                 
Asp Cys Pro Pro Gly Ser Phe Trp Trp Leu Ile Pro Leu Leu Leu Leu
705                 710                 715                 720 
Leu Leu Pro Leu Leu Ala Leu Leu Leu Leu Leu Cys Trp Lys Tyr Cys
                725                 730                 735     
Ala Cys Cys Lys Ala Cys Leu Ala Leu Leu Pro Cys Cys Asn Arg Gly
            740                 745                 750         
His Met Val Gly Phe Lys Glu Asp His Tyr Met Leu Arg Glu Asn Leu
        755                 760                 765             
Met Ala Ser Asp His Leu Asp Thr Pro Met Leu Arg Ser Gly Asn Leu
    770                 775                 780                 
Lys Gly Arg Asp Val Val Arg Trp Lys Val Thr Asn Asn Met Gln Arg
785                 790                 795                 800 
Pro Gly Phe Ala Thr His Ala Ala Ser Ile Asn Pro Thr Glu Leu Val
                805                 810                 815     
Pro Tyr Gly Leu Ser Leu Arg Leu Ala Arg Leu Cys Thr Glu Asn Leu
            820                 825                 830         
Leu Lys Pro Asp Thr Arg Glu Cys Ala Gln Leu Arg Gln Glu Val Glu
        835                 840                 845             
Glu Asn Leu Asn Glu Val Tyr Arg Gln Ile Ser Gly Val His Lys Leu
    850                 855                 860                 
Gln Gln Thr Lys Phe Arg Gln Gln Pro Asn Ala Gly Lys Lys Gln Asp
865                 870                 875                 880 
His Thr Ile Val Asp Thr Val Leu Met Ala Pro Arg Ser Ala Lys Pro
                885                 890                 895     
Ala Leu Leu Lys Leu Thr Glu Lys Gln Val Glu Gln Arg Ala Phe His
            900                 905                 910         
Asp Leu Lys Val Ala Pro Gly Tyr Tyr Thr Leu Thr Ala Asp Gln Asp
        915                 920                 925             
Ala Arg Gly Met Val Glu Phe Gln Glu Gly Val Glu Leu Val Asp Val
    930                 935                 940                 
Arg Val Pro Leu Phe Ile Arg Pro Glu Asp Asp Asp Glu Lys Gln Leu
945                 950                 955                 960 
Leu Val Glu Ala Ile Asp Val Pro Ala Gly Thr Ala Thr Leu Gly Arg
                965                 970                 975     
Arg Leu Val Asn Ile Thr Ile Ile Lys Glu Gln Ala Arg Asp Val Val
            980                 985                 990         
Ser Phe Glu Gln Pro Glu Phe Ser Val Ser Arg Gly Asp Gln Val Ala
        995                 1000                1005            
Arg Ile Pro Val Ile Arg Arg Val Leu Asp Gly Gly Lys Ser Gln Val
    1010                1015                1020                
Ser Tyr Arg Thr Gln Asp Gly Thr Ala Gln Gly Asn Arg Asp Tyr Ile
1025                1030                1035                1040
Pro Val Glu Gly Glu Leu Leu Phe Gln Pro Gly Glu Ala Trp Lys Glu
                1045                1050                1055    
Leu Gln Val Lys Leu Leu Glu Leu Gln Glu Val Asp Ser Leu Leu Arg
            1060                1065                1070        
Gly Arg Gln Val Arg Arg Phe His Val Gln Leu Ser Asn Pro Lys Phe
        1075                1080                1085            
Gly Ala His Leu Gly Gln Pro His Ser Thr Thr Ile Ile Ile Arg Asp
    1090                1095                1100                
Pro Asp Glu Leu Asp Arg Ser Phe Thr Ser Gln Met Leu Ser Ser Gln
1105                1110                1115                1120
Pro Pro Pro His Gly Asp Leu Gly Ala Pro Gln Asn Pro Asn Ala Lys
                1125                1130                1135    
Ala Ala Gly Ser Arg Lys Ile His Phe Asn Trp Leu Pro Pro Ser Gly
            1140                1145                1150        
Lys Pro Met Gly Tyr Arg Val Lys Tyr Trp Ile Gln Gly Asp Ser Glu
        1155                1160                1165            
Ser Glu Ala His Leu Leu Asp Ser Lys Val Pro Ser Val Glu Leu Thr
    1170                1175                1180                
Asn Leu Tyr Pro Tyr Cys Asp Tyr Glu Met Lys Val Cys Ala Tyr Gly
1185                1190                1195                1200
Ala Gln Gly Glu Gly Pro Tyr Ser Ser Leu Val Ser Cys Arg Thr His
                1205                1210                1215    
Gln Glu Val Pro Ser Glu Pro Gly Arg Leu Ala Phe Asn Val Val Ser
            1220                1225                1230        
Ser Thr Val Thr Gln Leu Ser Trp Ala Glu Pro Ala Glu Thr Asn Gly
        1235                1240                1245            
Glu Ile Thr Ala Tyr Glu Val Cys Tyr Gly Leu Val Asn Asp Asp Asn
    1250                1255                1260                
Arg Pro Ile Gly Pro Met Lys Lys Val Leu Val Asp Asn Pro Lys Asn
1265                1270                1275                1280
Arg Met Leu Leu Ile Glu Asn Leu Arg Glu Ser Gln Pro Tyr Arg Tyr
                1285                1290                1295    
Thr Val Lys Ala Arg Asn Gly Ala Gly Trp Gly Pro Glu Arg Glu Ala
            1300                1305                1310        
Ile Ile Asn Leu Ala Thr Gln Pro Lys Arg Pro Met Ser Ile Pro Ile
        1315                1320                1325            
Ile Pro Asp Ile Pro Ile Val Asp Ala Gln Ser Gly Glu Asp Tyr Asp
    1330                1335                1340                
Ser Phe Leu Met Tyr Ser Asp Asp Val Leu Arg Ser Pro Ser Gly Ser
1345                1350                1355                1360
Gln Arg Pro Ser Val Ser Asp Asp Thr Glu His Leu Val Asn Gly Arg
                1365                1370                1375    
Met Asp Phe Ala Phe Pro Gly Ser Thr Asn Ser Leu His Arg Met Thr
            1380                1385                1390        
Thr Thr Ser Ala Ala Ala Tyr Gly Thr His Leu Ser Pro His Val Pro
        1395                1400                1405            
His Arg Val Leu Ser Thr Ser Ser Thr Leu Thr Arg Asp Tyr Asn Ser
    1410                1415                1420                
Leu Thr Arg Ser Glu His Ser His Ser Thr Thr Leu Pro Arg Asp Tyr
1425                1430                1435                1440
Ser Thr Leu Thr Ser Val Ser Ser His Gly Leu Pro Pro Ile Trp Glu
                1445                1450                1455    
His Gly Arg Ser Arg Leu Pro Leu Ser Trp Ala Leu Gly Ser Arg Ser
            1460                1465                1470        
Arg Ala Gln Met Lys Gly Phe Pro Pro Ser Arg Gly Pro Arg Asp Ser
        1475                1480                1485            
Ile Ile Leu Ala Gly Arg Pro Ala Ala Pro Ser Trp Gly Pro Asp Ser
    1490                1495                1500                
Arg Leu Thr Ala Gly Val Pro Asp Thr Pro Thr Arg Leu Val Phe Ser
1505                1510                1515                1520
Ala Leu Gly Pro Thr Ser Leu Arg Val Ser Trp Gln Glu Pro Arg Cys
                1525                1530                1535    
Glu Arg Pro Leu Gln Gly Tyr Ser Val Glu Tyr Gln Leu Leu Asn Gly
            1540                1545                1550        
Gly Glu Leu His Arg Leu Asn Ile Pro Asn Pro Ala Gln Thr Ser Val
        1555                1560                1565            
Val Val Glu Asp Leu Leu Pro Asn His Ser Tyr Val Phe Arg Val Arg
    1570                1575                1580                
Ala Gln Ser Gln Glu Gly Trp Gly Arg Glu Arg Glu Gly Val Ile Thr
1585                1590                1595                1600
Ile Glu Ser Gln Val His Pro Gln Ser Pro Leu Cys Pro Leu Pro Gly
                1605                1610                1615    
Ser Ala Phe Thr Leu Ser Thr Pro Ser Ala Pro Gly Pro Leu Val Phe
            1620                1625                1630        
Thr Ala Leu Ser Pro Asp Ser Leu Gln Leu Ser Trp Glu Arg Pro Arg
        1635                1640                1645            
Arg Pro Asn Gly Asp Ile Val Gly Tyr Leu Val Thr Cys Glu Met Ala
    1650                1655                1660                
Gln Gly Gly Gly Pro Ala Thr Ala Phe Arg Val Asp Gly Asp Ser Pro
1665                1670                1675                1680
Glu Ser Arg Leu Thr Val Pro Gly Leu Ser Glu Asn Val Pro Tyr Lys
                1685                1690                1695    
Phe Lys Val Gln Ala Arg Thr Thr Glu Gly Phe Gly Pro Glu Arg Glu
            1700                1705                1710        
Gly Ile Ile Thr Ile Glu Ser Gln Asp Gly Gly Pro Phe Pro Gln Leu
        1715                1720                1725            
Gly Ser Arg Ala Gly Leu Phe Gln His Pro Leu Gln Ser Glu Tyr Ser
    1730                1735                1740                
Ser Ile Ser Thr Thr His Thr Ser Ala Thr Glu Pro Phe Leu Val Asp
1745                1750                1755                1760
Gly Pro Thr Leu Gly Ala Gln His Leu Glu Ala Gly Gly Ser Leu Thr
                1765                1770                1775    
Arg His Val Thr Gln Glu Phe Val Ser Arg Thr Leu Thr Thr Ser Gly
            1780                1785                1790        
Thr Leu Ser Thr His Met Asp Gln Gln Phe Phe Gln Thr
        1795                1800                1805


<210> 275
<211> 480
<212> PRT
<213> Homo sapiens

<400> 275
Met Ser Ala Glu Val Ile His Gln Val Glu Glu Ala Leu Asp Thr Asp
 1               5                  10                  15      
Glu Lys Glu Met Leu Leu Phe Leu Cys Arg Asp Val Ala Ile Asp Val
            20                  25                  30          
Val Pro Pro Asn Val Arg Asp Leu Leu Asp Ile Leu Arg Glu Arg Gly
        35                  40                  45              
Lys Leu Ser Val Gly Asp Leu Ala Glu Leu Leu Tyr Arg Val Arg Arg
    50                  55                  60                  
Phe Asp Leu Leu Lys Arg Ile Leu Lys Met Asp Arg Lys Ala Val Glu
65                  70                  75                  80  
Thr His Leu Leu Arg Asn Pro His Leu Val Ser Asp Tyr Arg Val Leu
                85                  90                  95      
Met Ala Glu Ile Gly Glu Asp Leu Asp Lys Ser Asp Val Ser Ser Leu
            100                 105                 110         
Ile Phe Leu Met Lys Asp Tyr Met Gly Arg Gly Lys Ile Ser Lys Glu
        115                 120                 125             
Lys Ile Ser Trp Asp Leu Val Val Glu Leu Glu Lys Leu Asn Leu Val
    130                 135                 140                 
Ala Pro Asp Gln Leu Asp Leu Leu Glu Lys Cys Leu Lys Asn Ile His
145                 150                 155                 160 
Arg Ile Asp Leu Lys Thr Lys Ile Gln Lys Tyr Lys Gln Ser Val Gln
                165                 170                 175     
Gly Ala Gly Thr Ser Tyr Arg Asn Val Leu Gln Ala Ala Ile Gln Lys
            180                 185                 190         
Ser Leu Lys Asp Pro Ser Asn Asn Phe Arg Leu His Asn Gly Arg Ser
        195                 200                 205             
Lys Glu Gln Arg Leu Lys Glu Gln Leu Gly Ala Gln Gln Glu Pro Val
    210                 215                 220                 
Lys Lys Ser Ile Gln Glu Ser Glu Ala Phe Leu Pro Gln Ser Ile Pro
225                 230                 235                 240 
Glu Glu Arg Tyr Lys Met Lys Ser Lys Pro Leu Gly Ile Cys Leu Ile
                245                 250                 255     
Ile Asp Cys Ile Gly Asn Glu Thr Glu Leu Leu Arg Asp Thr Phe Thr
            260                 265                 270         
Ser Leu Gly Tyr Glu Val Gln Lys Phe Leu His Leu Ser Met His Gly
        275                 280                 285             
Ile Ser Gln Ile Leu Gly Gln Phe Ala Cys Met Pro Glu His Arg Asp
    290                 295                 300                 
Tyr Asp Ser Phe Val Cys Val Leu Val Ser Arg Gly Gly Ser Gln Ser
305                 310                 315                 320 
Val Tyr Gly Val Asp Gln Thr His Ser Gly Leu Pro Leu His His Ile
                325                 330                 335     
Arg Arg Met Phe Met Gly Glu Ser Cys Pro Tyr Leu Ala Gly Lys Pro
            340                 345                 350         
Lys Met Phe Phe Ile Gln Asn Tyr Val Val Ser Glu Gly Pro Ala Gly
        355                 360                 365             
Asp Ser Ser Leu Trp Arg Val Asp Gly Pro Ala Met Lys Asn Val Glu
    370                 375                 380                 
Phe Arg Ala Gln Lys Arg Gly Leu Cys Thr Val His Arg Glu Ala Asp
385                 390                 395                 400 
Phe Phe Trp Ser Leu Cys Thr Ala Asp Met Ser Leu Leu Glu Gln Ser
                405                 410                 415     
His Ser Ser Pro Ser Leu Tyr Leu Gln Cys Leu Ser Gln Lys Leu Arg
            420                 425                 430         
Gln Glu Arg Lys Arg Pro Leu Leu Asp Leu His Ile Glu Leu Asn Gly
        435                 440                 445             
Tyr Met Tyr Asp Trp Asn Ser Arg Val Ser Ala Lys Glu Lys Tyr Tyr
    450                 455                 460                 
Val Trp Leu Gln His Thr Leu Arg Lys Lys Leu Ile Leu Ser Tyr Thr
465                 470                 475                 480 


<210> 276
<211> 755
<212> PRT
<213> Homo sapiens

<400> 276
Ala Asn Lys Ala Asn Thr Ser Gly Asp Phe Glu Lys Asp Asp Asp Ala
 1               5                  10                  15      
Tyr Lys Thr Glu Asp Ser Asp Asp Ile His Phe Glu Pro Val Val Gln
            20                  25                  30          
Met Pro Glu Lys Val Glu Leu Val Thr Gly Glu Glu Gly Glu Lys Val
        35                  40                  45              
Leu Tyr Ser Gln Gly Val Lys Leu Phe Arg Phe Asp Ala Glu Val Arg
    50                  55                  60                  
Gln Trp Lys Glu Arg Gly Leu Gly Asn Leu Lys Ile Leu Lys Asn Glu
65                  70                  75                  80  
Val Asn Gly Lys Leu Arg Met Leu Met Arg Arg Glu Gln Val Leu Lys
                85                  90                  95      
Val Cys Ala Asn His Trp Ile Thr Thr Thr Met Asn Leu Lys Pro Leu
            100                 105                 110         
Ser Gly Ser Asp Arg Ala Trp Met Trp Ser Ala Ser Asp Phe Ser Asp
        115                 120                 125             
Gly Asp Ala Lys Leu Glu Arg Leu Ala Ala Lys Phe Lys Thr Pro Glu
    130                 135                 140                 
Leu Ala Glu Glu Phe Lys Gln Lys Phe Glu Glu Cys Gln Arg Leu Leu
145                 150                 155                 160 
Leu Asp Ile Pro Leu Gln Thr Pro His Lys Leu Val Asp Thr Gly Arg
                165                 170                 175     
Ala Ala Lys Leu Ile Gln Arg Ala Glu Glu Met Lys Ser Gly Leu Lys
            180                 185                 190         
Asp Phe Lys Thr Phe Leu Thr Asn Asp Gln Thr Lys Val Thr Glu Glu
        195                 200                 205             
Glu Asn Lys Gly Ser Gly Thr Gly Val Ala Gly Ala Ser Asp Thr Thr
    210                 215                 220                 
Ile Lys Pro Asn Ala Glu Asn Thr Gly Pro Thr Leu Glu Trp Asp Asn
225                 230                 235                 240 
Tyr Asp Leu Arg Glu Asp Ala Leu Asp Asp Ser Val Ser Ser Ser Ser
                245                 250                 255     
Val His Ala Ser Pro Leu Ala Ser Ser Pro Val Arg Lys Asn Leu Phe
            260                 265                 270         
Arg Phe Asp Glu Ser Thr Thr Gly Ser Asn Phe Ser Phe Lys Ser Ala
        275                 280                 285             
Leu Ser Leu Ser Lys Ser Pro Ala Lys Leu Asn Gln Ser Gly Thr Ser
    290                 295                 300                 
Val Gly Thr Asp Glu Glu Ser Val Val Thr Gln Glu Glu Glu Arg Asp
305                 310                 315                 320 
Gly Gln Tyr Phe Glu Pro Val Val Pro Leu Pro Asp Leu Val Glu Val
                325                 330                 335     
Ser Ser Gly Glu Glu Asn Glu Gln Val Val Phe Ser His Arg Ala Glu
            340                 345                 350         
Ile Tyr Arg Tyr Asp Lys Asp Val Gly Gln Trp Lys Glu Arg Gly Ile
        355                 360                 365             
Gly Asp Ile Lys Ile Leu Gln Asn Tyr Asp Asn Lys Gln Val Arg Ile
    370                 375                 380                 
Val Met Arg Arg Asp Gln Val Leu Lys Leu Cys Ala Asn His Arg Ile
385                 390                 395                 400 
Thr Pro Asp Met Ser Leu Gln Asn Met Lys Gly Thr Glu Arg Val Trp
                405                 410                 415     
Val Trp Thr Ala Cys Asp Phe Ala Asp Gly Glu Arg Lys Val Glu His
            420                 425                 430         
Leu Ala Val Arg Phe Lys Leu Gln Asp Val Ala Asp Ser Phe Lys Lys
        435                 440                 445             
Ile Phe Asp Glu Ala Lys Thr Ala Gln Glu Lys Asp Ser Leu Ile Thr
    450                 455                 460                 
Pro His Val Ser Arg Ser Ser Thr Pro Arg Glu Ser Pro Cys Gly Lys
465                 470                 475                 480 
Ile Ala Val Ala Val Leu Glu Glu Ile Thr Arg Glu Arg Thr Asp Val
                485                 490                 495     
Ile Gln Gly Asp Asp Val Ala Asp Ala Ala Ser Glu Val Glu Val Ser
            500                 505                 510         
Ser Thr Ser Glu Thr Thr Thr Lys Ala Val Val Ser Pro Pro Lys Phe
        515                 520                 525             
Val Phe Gly Ser Glu Ser Val Lys Arg Ile Phe Ser Ser Glu Lys Ser
    530                 535                 540                 
Lys Pro Phe Ala Phe Gly Asn Ser Ser Ala Thr Gly Ser Leu Phe Gly
545                 550                 555                 560 
Phe Ser Phe Asn Ala Pro Leu Lys Ser Asn Asn Ser Glu Thr Ser Ser
                565                 570                 575     
Val Ala Gln Ser Gly Ser Glu Ser Lys Val Glu Pro Lys Lys Cys Glu
            580                 585                 590         
Leu Ser Lys Asn Ser Asp Ile Glu Gln Ser Ser Asp Ser Lys Val Lys
        595                 600                 605             
Asn Leu Ser Ala Ser Phe Pro Thr Glu Glu Ser Ser Ile Asn Tyr Thr
    610                 615                 620                 
Phe Lys Thr Pro Glu Lys Glu Pro Pro Leu Trp His Ala Glu Phe Thr
625                 630                 635                 640 
Lys Glu Glu Leu Val Gln Lys Leu Arg Ser Thr Thr Lys Ser Ala Asp
                645                 650                 655     
His Leu Asn Gly Leu Leu Arg Glu Ile Glu Ala Thr Asn Ala Val Leu
            660                 665                 670         
Met Glu Gln Ile Lys Leu Leu Lys Ser Glu Ile Arg Arg Leu Glu Arg
        675                 680                 685             
Asn Gln Glu Arg Glu Lys Ser Ala Ala Asn Leu Glu Tyr Leu Lys Asn
    690                 695                 700                 
Val Leu Leu Gln Phe Ile Phe Leu Lys Pro Gly Ser Glu Arg Glu Arg
705                 710                 715                 720 
Leu Leu Pro Val Ile Asn Thr Met Leu Gln Leu Ser Pro Glu Glu Lys
                725                 730                 735     
Gly Lys Leu Ala Ala Val Ala Gln Asp Glu Glu Glu Asn Pro Ser Arg
            740                 745                 750         
Ser Ser Gly
        755 


<210> 277
<211> 2375
<212> PRT
<213> Homo sapiens

<400> 277
Met Gln Ser Leu Pro Lys Gly Thr Val Ile Val Gln Pro Glu Pro Val
 1               5                  10                  15      
Leu Asn Glu Asp Lys Asp Asp Phe Lys Gly Pro Glu Phe Arg Ser Arg
            20                  25                  30          
Ser Lys Met Lys Thr Glu Asn Leu Lys Lys Arg Gly Glu Asp Gly Leu
        35                  40                  45              
His Gly Ile Val Ser Cys Thr Ala Cys Gly Gln Gln Val Asn His Phe
    50                  55                  60                  
Gln Lys Asp Ser Ile Tyr Arg His Pro Ser Leu Gln Val Leu Ile Cys
65                  70                  75                  80  
Lys Asn Cys Phe Lys Tyr Tyr Met Ser Asp Asp Ile Ser Arg Asp Ser
                85                  90                  95      
Asp Gly Met Asp Glu Gln Cys Arg Trp Cys Ala Glu Gly Gly Asn Leu
            100                 105                 110         
Ile Cys Cys Asp Phe Cys His Asn Ala Phe Cys Lys Lys Cys Ile Leu
        115                 120                 125             
Arg Asn Leu Gly Arg Lys Glu Leu Ser Thr Ile Met Asp Glu Asn Asn
    130                 135                 140                 
Gln Trp Tyr Cys Tyr Ile Cys His Pro Glu Pro Leu Leu Asp Leu Val
145                 150                 155                 160 
Thr Ala Cys Asn Ser Val Phe Glu Asn Leu Glu Gln Leu Leu Gln Gln
                165                 170                 175     
Asn Lys Lys Lys Ile Lys Val Asp Ser Glu Lys Ser Asn Lys Val Tyr
            180                 185                 190         
Glu His Thr Ser Arg Phe Ser Pro Lys Lys Thr Ser Ser Asn Cys Asn
        195                 200                 205             
Gly Glu Glu Lys Lys Leu Asp Asp Ser Cys Ser Gly Ser Val Thr Tyr
    210                 215                 220                 
Ser Tyr Ser Ala Leu Ile Val Pro Lys Glu Met Ile Lys Lys Ala Lys
225                 230                 235                 240 
Lys Leu Ile Glu Thr Thr Ala Asn Met Asn Ser Ser Tyr Val Lys Phe
                245                 250                 255     
Leu Lys Gln Ala Thr Asp Asn Ser Glu Ile Ser Ser Ala Thr Lys Leu
            260                 265                 270         
Arg Gln Leu Lys Ala Phe Lys Ser Val Leu Ala Asp Ile Lys Lys Ala
        275                 280                 285             
His Leu Ala Leu Glu Glu Asp Leu Asn Ser Glu Phe Arg Ala Met Asp
    290                 295                 300                 
Ala Val Asn Lys Glu Lys Asn Thr Lys Glu His Lys Val Ile Asp Ala
305                 310                 315                 320 
Lys Phe Glu Thr Lys Ala Arg Lys Gly Glu Lys Pro Cys Ala Leu Glu
                325                 330                 335     
Lys Lys Asp Ile Ser Lys Ser Glu Ala Lys Leu Ser Arg Lys Gln Val
            340                 345                 350         
Asp Ser Glu His Met His Gln Asn Val Pro Thr Glu Glu Gln Arg Thr
        355                 360                 365             
Asn Lys Ser Thr Gly Gly Glu His Lys Lys Ser Asp Arg Lys Glu Glu
    370                 375                 380                 
Pro Gln Tyr Glu Pro Ala Asn Thr Ser Glu Asp Leu Asp Met Asp Ile
385                 390                 395                 400 
Val Ser Val Pro Ser Ser Val Pro Glu Asp Ile Phe Glu Asn Leu Glu
                405                 410                 415     
Thr Ala Met Glu Val Gln Ser Ser Val Asp His Gln Gly Asp Gly Ser
            420                 425                 430         
Ser Gly Thr Glu Gln Glu Val Glu Ser Ser Ser Val Lys Leu Asn Ile
        435                 440                 445             
Ser Ser Lys Asp Asn Arg Gly Gly Ile Lys Ser Lys Thr Thr Ala Lys
    450                 455                 460                 
Val Thr Lys Glu Leu Tyr Val Lys Leu Thr Pro Val Ser Leu Pro Asn
465                 470                 475                 480 
Ser Pro Ile Lys Gly Ala Asp Cys Gln Glu Val Pro Gln Asp Lys Asp
                485                 490                 495     
Gly Tyr Lys Ser Cys Gly Leu Asn Pro Lys Leu Glu Lys Cys Gly Leu
            500                 505                 510         
Gly Gln Glu Asn Ser Asp Asn Glu His Leu Val Glu Asn Glu Val Ser
        515                 520                 525             
Leu Leu Leu Glu Glu Ser Asp Leu Arg Arg Ser Pro Arg Val Lys Thr
    530                 535                 540                 
Thr Pro Leu Arg Arg Pro Thr Glu Thr Asn Pro Val Thr Ser Asn Ser
545                 550                 555                 560 
Asp Glu Glu Cys Asn Glu Thr Val Lys Glu Lys Gln Lys Leu Ser Val
                565                 570                 575     
Pro Val Arg Lys Lys Asp Lys Arg Asn Ser Ser Asp Ser Ala Ile Asp
            580                 585                 590         
Asn Pro Lys Pro Asn Lys Leu Pro Lys Ser Lys Gln Ser Glu Thr Val
        595                 600                 605             
Asp Gln Asn Ser Asp Ser Asp Glu Met Leu Ala Ile Leu Lys Gly Val
    610                 615                 620                 
Ser Arg Met Ser His Ser Ser Ser Ser Asp Thr Asp Ile Asn Glu Ile
625                 630                 635                 640 
His Thr Asn His Lys Thr Leu Tyr Asp Leu Lys Thr Gln Ala Gly Lys
                645                 650                 655     
Asp Asp Lys Gly Lys Arg Lys Arg Lys Ser Ser Thr Ser Gly Ser Asp
            660                 665                 670         
Phe Asp Thr Lys Lys Gly Lys Ser Ala Lys Ser Ser Ile Ile Ser Lys
        675                 680                 685             
Lys Lys Arg Gln Thr Gln Ser Glu Ser Ser Asn Tyr Asp Ser Glu Leu
    690                 695                 700                 
Glu Lys Glu Ile Lys Ser Met Ser Lys Ile Gly Ala Ala Arg Thr Thr
705                 710                 715                 720 
Lys Lys Arg Ile Pro Asn Thr Lys Asp Phe Asp Ser Ser Glu Asp Glu
                725                 730                 735     
Lys His Ser Lys Lys Gly Met Asp Asn Gln Gly His Lys Asn Leu Lys
            740                 745                 750         
Thr Ser Gln Glu Gly Ser Ser Asp Asp Ala Glu Arg Lys Gln Glu Arg
        755                 760                 765             
Glu Thr Phe Ser Ser Ala Glu Gly Thr Val Asp Lys Asp Thr Thr Ile
    770                 775                 780                 
Met Glu Leu Arg Asp Arg Leu Pro Lys Lys Gln Gln Ala Ser Ala Ser
785                 790                 795                 800 
Thr Asp Gly Val Asp Lys Leu Ser Gly Lys Glu Gln Ser Phe Thr Ser
                805                 810                 815     
Leu Glu Val Arg Lys Val Ala Glu Thr Lys Glu Lys Ser Lys His Leu
            820                 825                 830         
Lys Thr Lys Thr Cys Lys Lys Val Gln Asp Gly Leu Ser Asp Ile Ala
        835                 840                 845             
Glu Lys Phe Leu Lys Lys Asp Gln Ser Asp Glu Thr Ser Glu Asp Asp
    850                 855                 860                 
Lys Lys Gln Ser Lys Lys Gly Thr Glu Glu Lys Lys Lys Pro Ser Asp
865                 870                 875                 880 
Phe Lys Lys Lys Val Ile Lys Met Glu Gln Gln Tyr Glu Ser Ser Ser
                885                 890                 895     
Asp Gly Thr Glu Lys Leu Pro Glu Arg Glu Glu Ile Cys His Phe Pro
            900                 905                 910         
Lys Gly Ile Lys Gln Ile Lys Asn Gly Thr Thr Asp Gly Glu Lys Lys
        915                 920                 925             
Ser Lys Lys Ile Arg Asp Lys Thr Ser Lys Lys Lys Asp Glu Leu Ser
    930                 935                 940                 
Asp Tyr Ala Glu Lys Ser Thr Gly Lys Gly Asp Ser Cys Asp Ser Ser
945                 950                 955                 960 
Glu Asp Lys Lys Ser Lys Asn Gly Ala Tyr Gly Arg Glu Lys Lys Arg
                965                 970                 975     
Cys Lys Leu Leu Gly Lys Ser Ser Arg Lys Arg Gln Asp Cys Ser Ser
            980                 985                 990         
Ser Asp Thr Glu Lys Tyr Ser Met Lys Glu Asp Gly Cys Asn Ser Ser
        995                 1000                1005            
Asp Lys Arg Leu Lys Arg Ile Glu Leu Arg Glu Arg Arg Asn Leu Ser
    1010                1015                1020                
Ser Lys Arg Asn Thr Lys Glu Ile Gln Ser Gly Ser Ser Ser Ser Asp
1025                1030                1035                1040
Ala Glu Glu Ser Ser Glu Asp Asn Lys Lys Lys Lys Gln Arg Thr Ser
                1045                1050                1055    
Ser Lys Lys Lys Ala Val Ile Val Lys Glu Lys Lys Arg Asn Ser Leu
            1060                1065                1070        
Arg Thr Ser Thr Lys Arg Lys Gln Ala Asp Ile Thr Ser Ser Ser Ser
        1075                1080                1085            
Ser Asp Ile Glu Asp Asp Asp Gln Asn Ser Ile Gly Glu Gly Ser Ser
    1090                1095                1100                
Asp Glu Gln Lys Ile Lys Pro Val Thr Glu Asn Leu Val Leu Ser Ser
1105                1110                1115                1120
His Thr Gly Phe Cys Gln Ser Ser Gly Asp Glu Ala Leu Ser Lys Ser
                1125                1130                1135    
Val Pro Val Thr Val Asp Asp Asp Asp Asp Asp Asn Asp Pro Glu Asn
            1140                1145                1150        
Arg Ile Ala Lys Lys Met Leu Leu Glu Glu Ile Lys Ala Asn Leu Ser
        1155                1160                1165            
Ser Asp Glu Asp Gly Ser Ser Asp Asp Glu Pro Glu Glu Gly Lys Lys
    1170                1175                1180                
Arg Thr Gly Lys Gln Asn Glu Glu Asn Pro Gly Asp Glu Glu Ala Lys
1185                1190                1195                1200
Asn Gln Val Asn Ser Glu Ser Asp Ser Asp Ser Glu Glu Ser Lys Lys
                1205                1210                1215    
Pro Arg Tyr Arg His Arg Leu Leu Arg His Lys Leu Thr Val Ser Asp
            1220                1225                1230        
Gly Glu Ser Gly Glu Glu Lys Lys Thr Lys Pro Lys Glu His Lys Glu
        1235                1240                1245            
Val Lys Gly Arg Asn Arg Arg Lys Val Ser Ser Glu Asp Ser Glu Asp
    1250                1255                1260                
Ser Asp Phe Gln Glu Ser Gly Val Ser Glu Glu Val Ser Glu Ser Glu
1265                1270                1275                1280
Asp Glu Gln Arg Pro Arg Thr Arg Ser Ala Lys Lys Ala Glu Leu Glu
                1285                1290                1295    
Glu Asn Gln Arg Ser Tyr Lys Gln Lys Lys Lys Arg Arg Arg Ile Lys
            1300                1305                1310        
Val Gln Glu Asp Ser Ser Ser Glu Asn Lys Ser Asn Ser Glu Glu Glu
        1315                1320                1325            
Glu Glu Glu Lys Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
    1330                1335                1340                
Glu Glu Glu Asp Glu Asn Asp Asp Ser Lys Ser Pro Gly Lys Gly Arg
1345                1350                1355                1360
Lys Lys Ile Arg Lys Ile Leu Lys Asp Asp Lys Leu Arg Thr Glu Thr
                1365                1370                1375    
Gln Asn Ala Leu Lys Glu Glu Glu Glu Arg Arg Lys Arg Ile Ala Glu
            1380                1385                1390        
Arg Glu Arg Glu Arg Glu Lys Leu Arg Glu Val Ile Glu Ile Glu Asp
        1395                1400                1405            
Ala Ser Pro Thr Lys Cys Pro Ile Thr Thr Lys Leu Val Leu Asp Glu
    1410                1415                1420                
Asp Glu Glu Thr Lys Glu Pro Leu Val Gln Val His Arg Asn Met Val
1425                1430                1435                1440
Ile Lys Leu Lys Pro His Gln Val Asp Gly Val Gln Phe Met Trp Asp
                1445                1450                1455    
Cys Cys Cys Glu Ser Val Lys Lys Thr Lys Lys Ser Pro Gly Ser Gly
            1460                1465                1470        
Cys Ile Leu Ala His Cys Met Gly Leu Gly Lys Thr Leu Gln Val Val
        1475                1480                1485            
Ser Phe Leu His Thr Val Leu Leu Cys Asp Lys Leu Asp Phe Ser Thr
    1490                1495                1500                
Ala Leu Val Val Cys Pro Leu Asn Thr Ala Leu Asn Trp Met Asn Glu
1505                1510                1515                1520
Phe Glu Lys Trp Gln Glu Gly Leu Lys Asp Asp Glu Lys Leu Glu Val
                1525                1530                1535    
Ser Glu Leu Ala Thr Val Lys Arg Pro Gln Glu Arg Ser Tyr Met Leu
            1540                1545                1550        
Gln Arg Trp Gln Glu Asp Gly Gly Val Met Ile Ile Gly Tyr Glu Met
        1555                1560                1565            
Tyr Arg Asn Leu Ala Gln Gly Arg Asn Val Lys Ser Arg Lys Leu Lys
    1570                1575                1580                
Glu Ile Phe Asn Lys Ala Leu Val Asp Pro Gly Pro Asp Phe Val Val
1585                1590                1595                1600
Cys Asp Glu Gly His Ile Leu Lys Asn Glu Ala Ser Ala Val Ser Lys
                1605                1610                1615    
Ala Met Asn Ser Ile Arg Ser Arg Arg Arg Ile Ile Leu Thr Gly Thr
            1620                1625                1630        
Pro Leu Gln Asn Asn Leu Ile Glu Tyr His Cys Met Val Asn Phe Ile
        1635                1640                1645            
Lys Glu Asn Leu Leu Gly Ser Ile Lys Glu Phe Arg Asn Arg Phe Ile
    1650                1655                1660                
Asn Pro Ile Gln Asn Gly Gln Cys Ala Asp Ser Thr Met Val Asp Val
1665                1670                1675                1680
Arg Val Met Lys Lys Arg Ala His Ile Leu Tyr Glu Met Leu Ala Gly
                1685                1690                1695    
Cys Val Gln Arg Lys Asp Tyr Thr Ala Leu Thr Lys Phe Leu Pro Pro
            1700                1705                1710        
Lys His Glu Tyr Val Leu Ala Val Arg Met Thr Ser Ile Gln Cys Lys
        1715                1720                1725            
Leu Tyr Gln Tyr Tyr Leu Asp His Leu Thr Gly Val Gly Asn Asn Ser
    1730                1735                1740                
Glu Gly Gly Arg Gly Lys Ala Gly Ala Lys Leu Phe Gln Asp Phe Gln
1745                1750                1755                1760
Met Leu Ser Arg Ile Trp Thr His Pro Trp Cys Leu Gln Leu Asp Tyr
                1765                1770                1775    
Ile Ser Lys Glu Asn Lys Gly Tyr Phe Asp Glu Asp Ser Met Asp Glu
            1780                1785                1790        
Phe Ile Ala Ser Asp Ser Asp Glu Thr Ser Met Ser Leu Ser Ser Asp
        1795                1800                1805            
Asp Tyr Thr Lys Lys Lys Lys Lys Gly Lys Lys Gly Lys Lys Asp Ser
    1810                1815                1820                
Ser Ser Ser Gly Ser Gly Ser Asp Asn Asp Val Glu Val Ile Lys Val
1825                1830                1835                1840
Trp Asn Ser Arg Ser Arg Gly Gly Gly Glu Gly Asn Val Asp Glu Thr
                1845                1850                1855    
Gly Asn Asn Pro Ser Val Ser Leu Lys Leu Glu Glu Ser Lys Ala Thr
            1860                1865                1870        
Ser Ser Ser Asn Pro Ser Ser Pro Ala Pro Asp Trp Tyr Lys Asp Phe
        1875                1880                1885            
Val Thr Asp Ala Asp Ala Glu Val Leu Glu His Ser Gly Lys Met Val
    1890                1895                1900                
Leu Leu Phe Glu Ile Leu Arg Met Ala Glu Glu Ile Gly Asp Lys Val
1905                1910                1915                1920
Leu Val Phe Ser Gln Ser Leu Ile Ser Leu Asp Leu Ile Glu Asp Phe
                1925                1930                1935    
Leu Glu Leu Ala Ser Arg Glu Lys Thr Glu Asp Lys Asp Lys Pro Leu
            1940                1945                1950        
Ile Tyr Lys Gly Glu Gly Lys Trp Leu Arg Asn Ile Asp Tyr Tyr Arg
        1955                1960                1965            
Leu Asp Gly Ser Thr Thr Ala Gln Ser Arg Lys Lys Trp Ala Glu Glu
    1970                1975                1980                
Phe Asn Asp Glu Thr Asn Val Arg Gly Arg Leu Phe Ile Ile Ser Thr
1985                1990                1995                2000
Lys Ala Gly Ser Leu Gly Ile Asn Leu Val Ala Ala Asn Arg Val Ile
                2005                2010                2015    
Ile Phe Asp Ala Ser Trp Asn Pro Ser Tyr Asp Ile Gln Ser Ile Phe
            2020                2025                2030        
Arg Val Tyr Arg Phe Gly Gln Thr Lys Pro Val Tyr Val Tyr Arg Phe
        2035                2040                2045            
Leu Ala Gln Gly Thr Met Glu Asp Lys Ile Tyr Asp Arg Gln Val Thr
    2050                2055                2060                
Lys Gln Ser Leu Ser Phe Arg Val Val Asp Gln Gln Gln Val Glu Arg
2065                2070                2075                2080
His Phe Thr Met Asn Glu Leu Thr Glu Leu Tyr Thr Phe Glu Pro Asp
                2085                2090                2095    
Leu Leu Asp Asp Pro Asn Ser Glu Lys Lys Lys Lys Arg Asp Thr Pro
            2100                2105                2110        
Met Leu Pro Lys Asp Thr Ile Leu Ala Glu Leu Leu Gln Ile His Lys
        2115                2120                2125            
Glu His Ile Val Gly Tyr His Glu His Asp Ser Leu Leu Asp His Lys
    2130                2135                2140                
Glu Glu Glu Glu Leu Thr Glu Glu Glu Arg Lys Ala Ala Trp Ala Glu
2145                2150                2155                2160
Tyr Glu Ala Glu Lys Lys Val Leu Thr Met Arg Phe Asn Ile Pro Thr
                2165                2170                2175    
Gly Thr Asn Leu Pro Pro Val Ser Phe Asn Ser Gln Thr Pro Tyr Ile
            2180                2185                2190        
Pro Phe Asn Leu Gly Ala Leu Ser Ala Met Ser Asn Gln Gln Leu Glu
        2195                2200                2205            
Asp Leu Ile Asn Gln Gly Arg Glu Lys Val Val Glu Ala Thr Asn Ser
    2210                2215                2220                
Val Thr Ala Val Arg Ile Gln Pro Leu Glu Asp Ile Ile Ser Ala Val
2225                2230                2235                2240
Trp Lys Glu Asn Met Asn Leu Ser Glu Ala Gln Val Gln Ala Leu Ala
                2245                2250                2255    
Leu Ser Arg Gln Ala Ser Gln Glu Leu Asp Val Lys Arg Arg Glu Ala
            2260                2265                2270        
Ile Tyr Asn Asp Val Leu Thr Lys Gln Gln Met Leu Ile Ser Cys Val
        2275                2280                2285            
Gln Arg Ile Leu Met Asn Arg Arg Leu Gln Gln Gln Tyr Asn Gln Gln
    2290                2295                2300                
Gln Gln Gln Gln Met Thr Tyr Gln Gln Ala Thr Leu Gly His Leu Met
2305                2310                2315                2320
Met Pro Lys Pro Pro Asn Leu Ile Met Asn Pro Ser Asn Tyr Gln Gln
                2325                2330                2335    
Ile Asp Met Arg Gly Met Tyr Gln Pro Val Ala Gly Gly Met Gln Pro
            2340                2345                2350        
Pro Pro Leu Gln Arg Ala Pro Pro Pro Met Arg Ser Lys Asn Pro Gly
        2355                2360                2365            
Pro Ser Gln Gly Lys Ser Met
    2370                2375


<210> 278
<211> 113
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 2, 6, 16, 17
<223> Xaa = Any Amino Acid

<400> 278
Met Xaa Glu Phe Ile Xaa Glu Arg Asn Leu Thr Asn Val Arg Tyr Xaa
 1               5                  10                  15      
Xaa Lys Pro Ser Ala Ser Leu Pro Thr Leu Leu Asn Ile Arg Glu Phe
            20                  25                  30          
Thr Arg Glu Arg Asn Pro Met Asn Val Ser Asn Val Gly Lys His Leu
        35                  40                  45              
Ala Thr Asp His Pro Leu Leu Asn Thr Arg Glu Phe Ile Gln Glu Arg
    50                  55                  60                  
Asn Pro Met Asp Val Met Ser Val Gly Lys His Leu Ala Phe Val His
65                  70                  75                  80  
Thr Leu Leu Tyr Ile Arg Glu Tyr Ile Leu Glu Arg Asp Pro Met Asn
                85                  90                  95      
Val Arg Asn Val Gly Arg Pro Leu Ala Ser Phe Cys Cys Phe Phe Pro
            100                 105                 110         
Arg
    


<210> 279
<211> 434
<212> PRT
<213> Homo sapiens

<400> 279
Met Asp Phe Asn Gly Val Gln Phe Val Cys Arg Asn Leu Leu Lys Val
 1               5                  10                  15      
Ser Met Phe Leu Asn Thr Leu Thr Pro Lys Phe Tyr Val Ala Leu Thr
            20                  25                  30          
Gly Thr Ser Ser Leu Ile Ser Gly Leu Ile Leu Ile Phe Glu Trp Trp
        35                  40                  45              
Tyr Phe Arg Lys Tyr Gly Thr Ser Phe Ile Glu Gln Val Ser Val Ser
    50                  55                  60                  
His Leu Arg Pro Leu Leu Gly Gly Val Asp Asn Asn Ser Ser Asn Asn
65                  70                  75                  80  
Ser Asn Ser Ser Asn Gly Asp Ser Asp Ser Asn Arg Gln Ser Val Ser
                85                  90                  95      
Glu Cys Lys Val Trp Arg Asn Pro Leu Asn Leu Phe Arg Gly Ala Glu
            100                 105                 110         
Tyr Asn Arg Tyr Thr Trp Val Thr Gly Arg Glu Pro Leu Thr Tyr Tyr
        115                 120                 125             
Asp Met Asn Leu Ser Ala Gln Asp His Gln Thr Phe Phe Thr Cys Asp
    130                 135                 140                 
Ser Asp His Leu Arg Pro Ala Asp Ala Ile Met Gln Lys Ala Trp Arg
145                 150                 155                 160 
Glu Arg Asn Pro Gln Ala Arg Ile Ser Ala Ala His Glu Ala Leu Glu
                165                 170                 175     
Ile Asn Glu Thr Arg His Gln Cys Leu Gly Val His Gln Lys Lys Ala
            180                 185                 190         
Ser Asn Val Cys Gln Lys Thr Arg Glu Asp Gln Gly Ser Lys Ala Leu
        195                 200                 205             
Leu Glu Leu Gln Ala Tyr Ala Asp Val Gln Ala Val Leu Ala Lys Tyr
    210                 215                 220                 
Asp Asp Ile Ser Leu Pro Lys Ser Ala Thr Ile Cys Tyr Thr Ala Ala
225                 230                 235                 240 
Leu Leu Lys Ala Arg Ala Val Ser Asp Lys Phe Ser Pro Glu Ala Ala
                245                 250                 255     
Ser Arg Arg Gly Leu Ser Thr Ala Glu Met Asn Ala Val Glu Ala Ile
            260                 265                 270         
His Arg Ala Val Glu Phe Asn Pro His Val Pro Lys Tyr Leu Leu Glu
        275                 280                 285             
Met Lys Ser Leu Ile Leu Pro Pro Glu His Ile Leu Lys Arg Gly Asp
    290                 295                 300                 
Ser Glu Ala Ile Ala Tyr Ala Phe Phe His Leu Ala His Trp Lys Arg
305                 310                 315                 320 
Val Glu Gly Ala Leu Asn Leu Leu His Cys Thr Trp Glu Gly Thr Phe
                325                 330                 335     
Arg Met Ile Pro Tyr Pro Leu Glu Lys Gly His Leu Phe Tyr Pro Tyr
            340                 345                 350         
Pro Ile Cys Thr Glu Thr Ala Asp Arg Glu Leu Leu Pro Ser Phe His
        355                 360                 365             
Glu Val Ser Val Tyr Pro Lys Lys Glu Leu Pro Phe Phe Ile Leu Phe
    370                 375                 380                 
Thr Ala Gly Leu Cys Ser Phe Thr Ala Met Leu Ala Leu Leu Thr His
385                 390                 395                 400 
Gln Phe Pro Glu Leu Met Gly Val Phe Ala Lys Ala Val Ser Val Cys
                405                 410                 415     
Leu Glu Gly Gly Leu Gly Glu Trp Met Gly Lys Ala Lys Gly Ile Lys
            420                 425                 430         
Ala Ala
        


<210> 280
<211> 296
<212> PRT
<213> Homo sapiens

<400> 280
Asp Phe Glu Glu Val His Val Ser Ser Asn Ala Asp Glu Glu Asp Ile
 1               5                  10                  15      
Arg Asn Ala Ile Met Ala Ile Arg Arg Asn Arg Val Ala Leu Lys Gly
            20                  25                  30          
Asn Ile Glu Thr Asn His Asn Leu Pro Pro Ser His Lys Ser Arg Asn
        35                  40                  45              
Asn Ile Leu Arg Thr Ser Leu Asp Leu Tyr Ala Asn Val Ile His Trp
    50                  55                  60                  
Lys Ser Leu Pro Gly Val Val Thr Arg His Lys Asp Ile Asp Ile Leu
65                  70                  75                  80  
Ile Val Arg Glu Asn Thr Glu Gly Glu Tyr Ser Ser Leu Glu His Glu
                85                  90                  95      
Ser Val Ala Gly Val Val Glu Ser Leu Lys Ile Ile Thr Lys Ala Lys
            100                 105                 110         
Ser Leu Arg Ile Ala Glu Tyr Ala Phe Lys Leu Ala Gln Glu Ser Gly
        115                 120                 125             
Arg Lys Lys Val Thr Ala Val His Lys Ala Asn Ile Met Lys Leu Gly
    130                 135                 140                 
Asp Gly Leu Phe Leu Gln Cys Cys Arg Glu Val Ala Ala Arg Tyr Pro
145                 150                 155                 160 
Gln Ile Thr Phe Glu Asn Met Ile Val Asp Asn Thr Thr Met Gln Leu
                165                 170                 175     
Val Ser Arg Pro Gln Gln Phe Asp Val Met Val Met Pro Asn Leu Tyr
            180                 185                 190         
Gly Asn Ile Val Asn Asn Val Cys Ala Gly Leu Val Gly Gly Pro Gly
        195                 200                 205             
Leu Val Ala Gly Ala Asn Tyr Gly His Val Tyr Ala Val Phe Glu Thr
    210                 215                 220                 
Ala Thr Arg Asn Thr Gly Lys Ser Ile Ala Asn Lys Asn Ile Ala Asn
225                 230                 235                 240 
Pro Thr Ala Thr Leu Leu Ala Ser Cys Met Met Leu Asp His Leu Lys
                245                 250                 255     
Leu His Ser Tyr Ala Thr Ser Ile Arg Lys Ala Val Leu Ala Ser Met
            260                 265                 270         
Asp Asn Glu Asn Val Arg Phe Pro Ser His Pro Thr Leu Leu Pro Arg
        275                 280                 285             
Pro Val Ser Pro Cys Ser Leu Leu
    290                 295     


<210> 281
<211> 79
<212> PRT
<213> Homo sapiens

<400> 281
Val Lys Thr Lys Ser Gly Lys Trp His Thr Val Thr Asn Leu Arg Ala
 1               5                  10                  15      
Ile Asn Ala Val Ile Lys Pro Met Gly Asp Val Gln Ala Gly Met Pro
            20                  25                  30          
Ala Pro Ala Leu Ile Pro Lys Asp Trp Pro Phe Ile Val Ile Asp Leu
        35                  40                  45              
Lys Asp Phe Phe Ile Leu Leu Tyr Ile Asn Trp Ile Val Lys Asn Leu
    50                  55                  60                  
Leu Leu Leu Tyr His Leu Ser Ile Ile Arg Ser Leu Gln Leu Ile
65                  70                  75                  


<210> 282
<211> 114
<212> PRT
<213> Homo sapiens

<400> 282
Met Tyr Tyr Lys Phe Ser Gly Phe Thr Gln Lys Leu Ala Gly Ala Trp
 1               5                  10                  15      
Ala Ser Glu Ala Tyr Ser Pro Gln Gly Leu Lys Pro Val Val Ser Thr
            20                  25                  30          
Glu Ala Pro Pro Ile Ile Phe Ala Thr Pro Thr Lys Leu Thr Ser Asp
        35                  40                  45              
Ser Thr Val Tyr Asp Tyr Ala Gly Lys Asn Lys Val Pro Glu Leu Gln
    50                  55                  60                  
Lys Phe Phe Gln Lys Ala Asp Gly Val Pro Val Tyr Leu Lys Arg Gly
65                  70                  75                  80  
Leu Pro Asp Gln Met Leu Tyr Arg Thr Thr Met Ala Leu Thr Val Gly
                85                  90                  95      
Gly Thr Ile Tyr Cys Leu Ile Ala Leu Tyr Asn Ala Ser Gln Pro Lys
            100                 105                 110         
Asn Lys
        


<210> 283
<211> 1884
<212> PRT
<213> Homo sapiens

<400> 283
Val Ala Gly Cys Arg Arg Arg Gly Ala Gly Asp Pro Asn Met Ala Asn
 1               5                  10                  15      
Leu Glu Glu Ser Phe Pro Arg Gly Gly Thr Arg Lys Ile His Lys Pro
            20                  25                  30          
Glu Lys Ala Phe Gln Gln Ser Val Glu Gln Asp Asn Leu Phe Asp Ile
        35                  40                  45              
Ser Thr Glu Glu Gly Ser Thr Lys Arg Lys Lys Ser Gln Lys Gly Pro
    50                  55                  60                  
Ala Lys Thr Lys Lys Leu Lys Ile Glu Lys Arg Glu Ser Ser Lys Ser
65                  70                  75                  80  
Ala Arg Glu Lys Phe Glu Ile Leu Ser Val Glu Ser Leu Cys Glu Gly
                85                  90                  95      
Met Arg Ile Leu Gly Cys Val Lys Glu Val Asn Glu Leu Glu Leu Val
            100                 105                 110         
Ile Ser Leu Pro Asn Gly Leu Gln Gly Phe Val Gln Val Thr Glu Ile
        115                 120                 125             
Cys Asp Ala Tyr Thr Lys Lys Leu Asn Glu Gln Val Thr Gln Glu Gln
    130                 135                 140                 
Pro Leu Lys Asp Leu Leu His Leu Pro Glu Leu Phe Ser Pro Gly Met
145                 150                 155                 160 
Leu Val Arg Cys Val Val Ser Ser Leu Gly Ile Thr Asp Arg Gly Lys
                165                 170                 175     
Lys Ser Val Lys Leu Ser Leu Asn Pro Lys Asn Val Asn Arg Val Leu
            180                 185                 190         
Ser Ala Glu Ala Leu Lys Pro Gly Met Leu Leu Thr Gly Thr Val Ser
        195                 200                 205             
Ser Leu Glu Asp His Gly Tyr Leu Val Asp Ile Gly Val Asp Gly Thr
    210                 215                 220                 
Arg Ala Phe Leu Pro Leu Leu Lys Ala Gln Glu Tyr Ile Arg Gln Lys
225                 230                 235                 240 
Asn Lys Gly Ala Lys Leu Lys Val Gly Gln Tyr Leu Asn Cys Ile Val
                245                 250                 255     
Glu Lys Val Lys Gly Asn Gly Gly Val Val Ser Leu Ser Val Gly His
            260                 265                 270         
Ser Glu Val Ser Thr Ala Ile Ala Thr Glu Gln Gln Ser Trp Asn Leu
        275                 280                 285             
Asn Asn Leu Leu Pro Gly Leu Val Val Lys Ala Gln Val Gln Lys Val
    290                 295                 300                 
Thr Pro Phe Gly Leu Thr Leu Asn Phe Leu Thr Phe Phe Thr Gly Val
305                 310                 315                 320 
Val Asp Phe Met His Leu Asp Pro Lys Lys Ala Gly Thr Tyr Phe Ser
                325                 330                 335     
Asn Gln Ala Val Arg Ala Cys Ile Leu Cys Val His Pro Arg Thr Arg
            340                 345                 350         
Val Val His Leu Ser Leu Arg Pro Ile Phe Leu Gln Pro Gly Arg Pro
        355                 360                 365             
Leu Thr Arg Leu Ser Cys Gln Asn Leu Gly Ala Val Leu Asp Asp Val
    370                 375                 380                 
Pro Val Gln Gly Phe Phe Lys Lys Ala Gly Ala Thr Phe Arg Leu Lys
385                 390                 395                 400 
Asp Gly Val Leu Ala Tyr Ala Arg Leu Ser His Leu Ser Asp Ser Lys
                405                 410                 415     
Asn Val Phe Asn Pro Glu Ala Phe Lys Pro Gly Asn Thr His Lys Cys
            420                 425                 430         
Arg Ile Ile Asp Tyr Ser Gln Met Asp Glu Leu Ala Leu Leu Ser Leu
        435                 440                 445             
Arg Thr Ser Ile Ile Glu Ala Gln Tyr Leu Arg Tyr His Asp Ile Glu
    450                 455                 460                 
Pro Gly Ala Val Val Lys Gly Thr Val Leu Thr Ile Lys Ser Tyr Gly
465                 470                 475                 480 
Met Leu Val Lys Val Gly Glu Gln Met Arg Gly Leu Val Pro Pro Met
                485                 490                 495     
His Leu Ala Asp Ile Leu Met Lys Asn Pro Glu Lys Lys Tyr His Ile
            500                 505                 510         
Gly Asp Glu Val Lys Cys Arg Val Leu Leu Cys Asp Pro Glu Ala Lys
        515                 520                 525             
Lys Leu Met Met Thr Leu Lys Lys Thr Leu Ile Glu Ser Lys Leu Pro
    530                 535                 540                 
Val Ile Thr Cys Tyr Ala Asp Ala Lys Pro Gly Leu Gln Thr His Gly
545                 550                 555                 560 
Phe Ile Ile Arg Val Lys Asp Tyr Gly Cys Ile Val Lys Phe Tyr Asn
                565                 570                 575     
Asn Val Gln Gly Leu Val Pro Lys His Glu Leu Ser Thr Glu Tyr Ile
            580                 585                 590         
Pro Asp Pro Glu Arg Val Phe Tyr Thr Gly Gln Val Val Lys Val Val
        595                 600                 605             
Val Leu Asn Cys Glu Pro Ser Lys Glu Arg Met Leu Leu Ser Phe Lys
    610                 615                 620                 
Leu Ser Ser Asp Pro Glu Pro Lys Lys Glu Pro Ala Gly His Ser Gln
625                 630                 635                 640 
Lys Lys Gly Lys Ala Ile Asn Ile Gly Gln Leu Val Asp Val Lys Val
                645                 650                 655     
Leu Glu Lys Thr Lys Asp Gly Leu Glu Val Ala Val Leu Pro His Asn
            660                 665                 670         
Ile Arg Ala Phe Leu Pro Thr Ser His Leu Ser Asp His Val Ala Asn
        675                 680                 685             
Gly Pro Leu Leu His His Trp Leu Gln Ala Gly Asp Ile Leu His Arg
    690                 695                 700                 
Val Leu Cys Leu Ser Gln Ser Glu Gly Arg Val Leu Leu Cys Arg Lys
705                 710                 715                 720 
Pro Ala Leu Val Ser Thr Val Glu Gly Gly Gln Asp Pro Lys Asn Phe
                725                 730                 735     
Ser Glu Ile His Pro Gly Met Leu Leu Ile Gly Phe Val Lys Ser Ile
            740                 745                 750         
Lys Asp Tyr Gly Val Phe Ile Gln Phe Pro Ser Gly Leu Ser Gly Leu
        755                 760                 765             
Ala Pro Lys Ala Ile Met Ser Asp Lys Phe Val Thr Ser Thr Ser Asp
    770                 775                 780                 
His Phe Val Glu Gly Gln Thr Val Ala Ala Lys Val Thr Asn Val Asp
785                 790                 795                 800 
Glu Glu Lys Gln Arg Met Leu Leu Ser Leu Arg Leu Ser Asp Cys Gly
                805                 810                 815     
Leu Gly Asp Leu Ala Ile Thr Ser Leu Leu Leu Leu Asn Gln Cys Leu
            820                 825                 830         
Glu Glu Leu Gln Gly Val Arg Ser Leu Met Ser Asn Arg Asp Ser Val
        835                 840                 845             
Leu Ile Gln Thr Leu Ala Glu Met Thr Pro Gly Met Phe Leu Asp Leu
    850                 855                 860                 
Val Val Gln Glu Val Leu Glu Asp Gly Ser Val Val Phe Ser Gly Gly
865                 870                 875                 880 
Pro Val Pro Asp Leu Val Leu Lys Ala Ser Arg Tyr His Arg Ala Gly
                885                 890                 895     
Gln Glu Val Glu Ser Gly Gln Lys Lys Lys Val Val Ile Leu Asn Val
            900                 905                 910         
Asp Leu Leu Lys Leu Glu Val His Val Ser Leu His Gln Asp Leu Val
        915                 920                 925             
Asn Arg Lys Ala Arg Lys Leu Arg Lys Gly Ser Glu His Gln Ala Ile
    930                 935                 940                 
Val Gln His Leu Glu Lys Ser Phe Ala Ile Ala Ser Leu Val Glu Thr
945                 950                 955                 960 
Gly His Leu Ala Ala Phe Ser Leu Thr Ser His Leu Asn Asp Thr Phe
                965                 970                 975     
Arg Phe Asp Ser Glu Lys Leu Gln Val Gly Gln Gly Val Ser Leu Thr
            980                 985                 990         
Leu Lys Thr Thr Glu Pro Gly Val Thr Gly Leu Leu Leu Ala Val Glu
        995                 1000                1005            
Gly Pro Ala Ala Lys Arg Thr Met Arg Pro Thr Gln Lys Asp Ser Glu
    1010                1015                1020                
Thr Val Asp Glu Asp Glu Glu Val Asp Pro Ala Leu Thr Val Gly Thr
1025                1030                1035                1040
Ile Lys Lys His Thr Leu Ser Ile Gly Asp Met Val Thr Gly Thr Val
                1045                1050                1055    
Lys Ser Ile Lys Pro Thr His Val Val Val Thr Leu Glu Asp Gly Ile
            1060                1065                1070        
Ile Gly Cys Ile His Ala Ser His Ile Leu Asp Asp Val Pro Glu Gly
        1075                1080                1085            
Thr Ser Pro Thr Thr Lys Leu Lys Val Gly Lys Thr Val Thr Ala Arg
    1090                1095                1100                
Val Ile Gly Gly Arg Asp Met Lys Thr Phe Lys Tyr Leu Pro Ile Ser
1105                1110                1115                1120
His Pro Arg Phe Val Arg Thr Ile Pro Glu Leu Ser Val Arg Pro Ser
                1125                1130                1135    
Glu Leu Glu Asp Gly His Thr Ala Leu Asn Thr His Ser Val Ser Pro
            1140                1145                1150        
Met Glu Lys Ile Lys Gln Tyr Gln Ala Gly Gln Thr Val Thr Cys Phe
        1155                1160                1165            
Leu Lys Lys Tyr Asn Val Val Lys Lys Trp Leu Glu Val Glu Ile Ala
    1170                1175                1180                
Pro Asp Ile Arg Gly Arg Ile Pro Leu Leu Leu Thr Ser Leu Ser Phe
1185                1190                1195                1200
Lys Val Leu Lys His Pro Asp Lys Lys Phe Arg Val Gly Gln Ala Leu
                1205                1210                1215    
Arg Ala Thr Val Val Gly Pro Asp Ser Ser Lys Thr Phe Leu Cys Leu
            1220                1225                1230        
Ser Leu Thr Gly Pro His Lys Leu Glu Glu Gly Glu Val Ala Met Gly
        1235                1240                1245            
Arg Val Val Lys Val Thr Pro Asn Glu Gly Leu Thr Val Ser Phe Pro
    1250                1255                1260                
Phe Gly Lys Ile Gly Thr Val Ser Ile Phe His Met Ser Asp Ser Tyr
1265                1270                1275                1280
Ser Glu Thr Pro Leu Glu Asp Phe Val Pro Gln Lys Val Val Arg Cys
                1285                1290                1295    
Tyr Ile Leu Ser Thr Ala Asp Asn Val Leu Thr Leu Ser Leu Arg Ser
            1300                1305                1310        
Ser Arg Thr Asn Pro Glu Thr Lys Ser Lys Val Glu Asp Pro Glu Ile
        1315                1320                1325            
Asn Ser Ile Gln Asp Ile Lys Glu Gly Gln Leu Leu Arg Gly Tyr Val
    1330                1335                1340                
Gly Ser Ile Gln Pro His Gly Val Phe Phe Arg Leu Gly Pro Ser Val
1345                1350                1355                1360
Val Gly Leu Ala Arg Tyr Ser His Val Ser Gln His Ser Pro Ser Lys
                1365                1370                1375    
Lys Ala Leu Tyr Asn Lys His Leu Pro Glu Gly Lys Leu Leu Thr Ala
            1380                1385                1390        
Arg Val Leu Arg Leu Asn His Gln Lys Asn Leu Val Glu Leu Ser Phe
        1395                1400                1405            
Leu Pro Gly Asp Thr Gly Lys Pro Asp Val Leu Ser Ala Ser Leu Glu
    1410                1415                1420                
Gly Gln Leu Thr Lys Gln Glu Glu Arg Lys Thr Glu Ala Glu Glu Arg
1425                1430                1435                1440
Asp Gln Lys Gly Glu Lys Lys Asn Gln Lys Arg Asn Glu Lys Lys Asn
                1445                1450                1455    
Gln Lys Gly Gln Glu Glu Val Glu Met Pro Ser Lys Glu Lys Gln Gln
            1460                1465                1470        
Pro Gln Lys Pro Gln Ala Gln Lys Arg Gly Gly Arg Glu Cys Arg Glu
        1475                1480                1485            
Ser Gly Ser Glu Gln Glu Arg Val Ser Lys Lys Pro Lys Lys Ala Gly
    1490                1495                1500                
Leu Ser Glu Glu Asp Asp Ser Leu Val Asp Val Tyr Tyr Arg Glu Gly
1505                1510                1515                1520
Lys Glu Glu Ala Glu Glu Thr Asn Val Leu Pro Lys Glu Lys Gln Thr
                1525                1530                1535    
Lys Pro Ala Glu Ala Pro Arg Leu Gln Leu Ser Ser Gly Phe Ala Trp
            1540                1545                1550        
Asn Val Gly Leu Asp Ser Leu Thr Pro Ala Leu Pro Pro Leu Ala Glu
        1555                1560                1565            
Ser Ser Asp Ser Glu Glu Asp Glu Lys Pro His Gln Ala Thr Ile Lys
    1570                1575                1580                
Lys Ser Lys Lys Glu Arg Glu Leu Glu Lys Gln Lys Ala Glu Lys Glu
1585                1590                1595                1600
Leu Ser Arg Ile Glu Glu Ala Leu Met Asp Pro Gly Arg Gln Pro Glu
                1605                1610                1615    
Ser Ala Asp Asp Phe Asp Arg Leu Val Leu Ser Ser Pro Asn Ser Ser
            1620                1625                1630        
Ile Leu Trp Leu Gln Tyr Met Ala Phe His Leu Gln Ala Thr Glu Ile
        1635                1640                1645            
Glu Lys Ala Arg Ala Val Ala Glu Arg Ala Leu Lys Thr Ile Ser Phe
    1650                1655                1660                
Arg Glu Glu Gln Glu Lys Leu Asn Val Trp Val Ala Leu Leu Asn Leu
1665                1670                1675                1680
Glu Asn Met Tyr Gly Ser Gln Glu Ser Leu Thr Lys Val Phe Glu Arg
                1685                1690                1695    
Ala Val Gln Tyr Asn Glu Pro Leu Lys Val Phe Leu His Leu Ala Asp
            1700                1705                1710        
Ile Tyr Ala Lys Ser Glu Lys Phe Gln Glu Ala Gly Glu Leu Tyr Asn
        1715                1720                1725            
Arg Met Leu Lys Arg Phe Arg Gln Glu Lys Ala Val Trp Ile Lys Tyr
    1730                1735                1740                
Gly Ala Phe Leu Leu Arg Arg Ser Gln Ala Ala Ala Ser His Arg Val
1745                1750                1755                1760
Leu Gln Arg Ala Leu Glu Cys Leu Pro Ser Lys Glu His Val Asp Val
                1765                1770                1775    
Ile Ala Lys Phe Ala Gln Leu Glu Phe Gln Leu Gly Asp Ala Glu Arg
            1780                1785                1790        
Ala Lys Ala Ile Phe Glu Asn Thr Leu Ser Thr Tyr Pro Lys Arg Thr
        1795                1800                1805            
Asp Val Trp Ser Val Tyr Ile Asp Met Thr Ile Lys His Gly Ser Gln
    1810                1815                1820                
Lys Asp Val Arg Asp Ile Phe Glu Arg Val Ile His Leu Ser Leu Ala
1825                1830                1835                1840
Pro Lys Arg Met Lys Phe Phe Phe Lys Arg Tyr Leu Asp Tyr Glu Lys
                1845                1850                1855    
Gln His Gly Thr Glu Lys Asp Val Gln Ala Val Lys Ala Lys Ala Leu
            1860                1865                1870        
Glu Tyr Val Glu Ala Lys Ser Ser Val Leu Glu Asp
        1875                1880                


<210> 284
<211> 1439
<212> PRT
<213> Homo sapiens

<400> 284
Met Asp Thr Thr Ala Ala Ala Ala Leu Pro Ala Phe Val Ala Leu Leu
 1               5                  10                  15      
Leu Leu Ser Pro Trp Pro Leu Leu Gly Ser Ala Gln Gly Gln Phe Ser
            20                  25                  30          
Ala Gly Gly Cys Thr Phe Asp Asp Gly Pro Gly Ala Cys Asp Tyr His
        35                  40                  45              
Gln Asp Leu Tyr Asp Asp Phe Glu Trp Val His Val Ser Ala Gln Glu
    50                  55                  60                  
Pro His Tyr Leu Pro Pro Glu Met Pro Gln Gly Ser Tyr Met Ile Val
65                  70                  75                  80  
Asp Ser Ser Asp His Asp Pro Gly Glu Lys Ala Arg Leu Gln Leu Pro
                85                  90                  95      
Thr Met Lys Glu Asn Asp Thr His Cys Ile Asp Phe Ser Tyr Leu Leu
            100                 105                 110         
Tyr Ser Gln Lys Gly Leu Asn Pro Gly Thr Leu Asn Ile Leu Val Arg
        115                 120                 125             
Val Asn Lys Gly Pro Leu Ala Asn Pro Ile Trp Asn Val Thr Gly Phe
    130                 135                 140                 
Thr Gly Arg Asp Trp Leu Arg Ala Glu Leu Ala Val Ser Ser Phe Trp
145                 150                 155                 160 
Pro Asn Glu Tyr Gln Val Ile Phe Glu Ala Glu Val Ser Gly Gly Arg
                165                 170                 175     
Ser Gly Tyr Ile Ala Ile Asp Asp Ile Gln Val Leu Ser Tyr Pro Cys
            180                 185                 190         
Asp Lys Ser Pro His Phe Leu Arg Leu Gly Asp Val Glu Val Asn Ala
        195                 200                 205             
Gly Gln Asn Ala Thr Phe Gln Cys Ile Ala Thr Gly Arg Asp Ala Val
    210                 215                 220                 
His Asn Lys Leu Trp Leu Gln Arg Arg Asn Gly Glu Asp Ile Pro Val
225                 230                 235                 240 
Ala Gln Thr Lys Asn Ile Asn His Arg Arg Phe Ala Ala Ser Phe Arg
                245                 250                 255     
Leu Gln Glu Val Thr Lys Thr Asp Gln Asp Leu Tyr Arg Cys Val Thr
            260                 265                 270         
Gln Ser Glu Arg Gly Ser Gly Val Ser Asn Phe Ala Gln Leu Ile Val
        275                 280                 285             
Arg Glu Pro Pro Arg Pro Ile Ala Pro Pro Gln Leu Leu Gly Val Gly
    290                 295                 300                 
Pro Thr Tyr Leu Leu Ile Gln Leu Asn Ala Asn Ser Ile Ile Gly Asp
305                 310                 315                 320 
Gly Pro Ile Ile Leu Lys Glu Val Glu Tyr Arg Met Thr Ser Gly Ser
                325                 330                 335     
Trp Thr Glu Thr His Ala Val Asn Ala Pro Thr Tyr Lys Leu Trp His
            340                 345                 350         
Leu Asp Pro Asp Thr Glu Tyr Glu Ile Arg Val Leu Leu Thr Arg Pro
        355                 360                 365             
Gly Glu Gly Gly Thr Gly Leu Pro Gly Pro Pro Leu Ile Thr Arg Thr
    370                 375                 380                 
Lys Cys Ala Glu Pro Met Arg Thr Pro Lys Thr Leu Lys Ile Ala Glu
385                 390                 395                 400 
Ile Gln Ala Arg Arg Ile Ala Val Asp Trp Glu Ser Leu Gly Tyr Asn
                405                 410                 415     
Ile Thr Arg Cys His Thr Phe Asn Val Thr Ile Cys Tyr His Tyr Phe
            420                 425                 430         
Arg Gly His Asn Glu Ser Lys Ala Asp Cys Leu Asp Met Asp Pro Lys
        435                 440                 445             
Ala Pro Gln His Val Val Asn His Leu Pro Pro Tyr Thr Asn Val Ser
    450                 455                 460                 
Leu Lys Met Ile Leu Thr Asn Pro Glu Gly Arg Lys Glu Ser Glu Glu
465                 470                 475                 480 
Thr Ile Ile Gln Thr Asp Glu Asp Val Pro Gly Pro Val Pro Val Lys
                485                 490                 495     
Ser Leu Gln Gly Thr Ser Phe Glu Asn Lys Ile Phe Leu Asn Trp Lys
            500                 505                 510         
Glu Pro Leu Asp Pro Asn Gly Ile Ile Thr Gln Tyr Glu Ile Ser Tyr
        515                 520                 525             
Ser Ser Ile Arg Ser Phe Asp Pro Ala Val Pro Val Ala Gly Pro Pro
    530                 535                 540                 
Gln Thr Val Ser Asn Leu Trp Asn Ser Thr His His Val Phe Met His
545                 550                 555                 560 
Leu His Pro Gly Thr Thr Tyr Gln Phe Phe Ile Arg Ala Ser Thr Val
                565                 570                 575     
Lys Gly Phe Gly Pro Ala Thr Ala Ile Asn Val Thr Thr Asn Ile Ser
            580                 585                 590         
Ala Pro Thr Leu Pro Asp Tyr Glu Gly Val Asp Ala Ser Leu Asn Glu
        595                 600                 605             
Thr Ala Thr Thr Ile Thr Val Leu Leu Arg Pro Ala Gln Ala Lys Gly
    610                 615                 620                 
Ala Pro Ile Ser Ala Tyr Gln Ile Val Val Glu Glu Leu His Pro His
625                 630                 635                 640 
Arg Thr Lys Arg Glu Ala Gly Ala Met Glu Cys Tyr Gln Val Pro Val
                645                 650                 655     
Thr Tyr Gln Asn Ala Met Ser Gly Gly Ala Pro Tyr Tyr Phe Ala Ala
            660                 665                 670         
Glu Leu Pro Pro Gly Asn Leu Pro Glu Pro Ala Pro Phe Thr Val Gly
        675                 680                 685             
Asp Asn Arg Thr Tyr Gln Gly Phe Trp Asn Pro Pro Leu Ala Pro Arg
    690                 695                 700                 
Lys Gly Tyr Asn Ile Tyr Phe Gln Ala Met Ser Ser Val Glu Lys Glu
705                 710                 715                 720 
Thr Lys Thr Gln Cys Val Arg Ile Ala Thr Lys Ala Ala Thr Glu Glu
                725                 730                 735     
Pro Glu Val Ile Pro Asp Pro Ala Lys Gln Thr Asp Arg Val Val Lys
            740                 745                 750         
Ile Ala Gly Ile Ser Ala Gly Ile Leu Val Phe Ile Leu Leu Leu Leu
        755                 760                 765             
Val Val Ile Leu Ile Val Lys Lys Ser Lys Leu Ala Lys Lys Arg Lys
    770                 775                 780                 
Asp Ala Met Gly Asn Thr Arg Gln Glu Met Thr His Met Val Asn Ala
785                 790                 795                 800 
Met Asp Arg Ser Tyr Ala Asp Gln Ser Thr Leu His Ala Glu Asp Pro
                805                 810                 815     
Leu Ser Ile Thr Phe Met Asp Gln His Asn Phe Ser Pro Arg Tyr Glu
            820                 825                 830         
Asn His Ser Ala Thr Ala Glu Ser Ser Arg Leu Leu Asp Val Pro Arg
        835                 840                 845             
Tyr Leu Cys Glu Gly Thr Glu Ser Pro Tyr Gln Thr Gly Gln Leu His
    850                 855                 860                 
Pro Ala Ile Arg Val Ala Asp Leu Leu Gln His Ile Asn Leu Met Lys
865                 870                 875                 880 
Thr Ser Asp Ser Tyr Gly Phe Lys Glu Glu Tyr Glu Ser Phe Phe Glu
                885                 890                 895     
Gly Gln Ser Ala Ser Trp Asp Val Ala Lys Lys Asp Gln Asn Arg Ala
            900                 905                 910         
Lys Asn Arg Tyr Gly Asn Ile Ile Ala Tyr Asp His Ser Arg Val Ile
        915                 920                 925             
Leu Gln Pro Val Glu Asp Asp Pro Ser Ser Asp Tyr Ile Asn Ala Asn
    930                 935                 940                 
Tyr Ile Asp Gly Tyr Gln Arg Pro Ser His Tyr Ile Ala Thr Gln Gly
945                 950                 955                 960 
Pro Val His Glu Thr Val Tyr Asp Phe Trp Arg Met Ile Trp Gln Glu
                965                 970                 975     
Gln Ser Ala Cys Ile Val Met Val Thr Asn Leu Val Glu Val Gly Arg
            980                 985                 990         
Val Lys Cys Tyr Lys Tyr Trp Pro Asp Asp Thr Glu Val Tyr Gly Asp
        995                 1000                1005            
Phe Lys Val Thr Cys Val Glu Met Glu Pro Leu Ala Glu Tyr Val Val
    1010                1015                1020                
Arg Thr Phe Thr Leu Glu Arg Arg Gly Tyr Asn Glu Ile Arg Glu Val
1025                1030                1035                1040
Lys Gln Phe His Phe Thr Gly Trp Pro Asp His Gly Val Pro Tyr His
                1045                1050                1055    
Ala Thr Gly Leu Leu Ser Phe Ile Arg Arg Val Lys Leu Ser Asn Pro
            1060                1065                1070        
Pro Ser Ala Gly Pro Ile Val Val His Cys Ser Ala Gly Ala Gly Arg
        1075                1080                1085            
Thr Gly Cys Tyr Ile Val Ile Asp Ile Met Leu Asp Met Ala Glu Arg
    1090                1095                1100                
Glu Gly Val Val Asp Ile Tyr Asn Cys Val Lys Ala Leu Arg Ser Arg
1105                1110                1115                1120
Arg Ile Asn Met Val Gln Thr Glu Glu Gln Tyr Ile Phe Ile His Asp
                1125                1130                1135    
Ala Ile Leu Glu Ala Cys Leu Cys Gly Glu Thr Ala Ile Pro Val Cys
            1140                1145                1150        
Glu Phe Lys Ala Ala Tyr Phe Asp Met Ile Arg Ile Asp Ser Gln Thr
        1155                1160                1165            
Asn Ser Ser His Leu Lys Asp Glu Phe Gln Thr Leu Asn Ser Val Thr
    1170                1175                1180                
Pro Arg Leu Gln Ala Glu Asp Cys Ser Ile Ala Cys Leu Pro Arg Asn
1185                1190                1195                1200
His Asp Lys Asn Arg Phe Met Asp Met Leu Pro Pro Asp Arg Cys Leu
                1205                1210                1215    
Pro Phe Leu Ile Thr Ile Asp Gly Glu Ser Ser Asn Tyr Ile Asn Ala
            1220                1225                1230        
Ala Leu Met Asp Ser Tyr Arg Gln Pro Ala Ala Phe Ile Val Thr Gln
        1235                1240                1245            
Tyr Pro Leu Pro Asn Thr Val Lys Asp Phe Trp Arg Leu Val Tyr Asp
    1250                1255                1260                
Tyr Gly Cys Thr Ser Ile Val Met Leu Asn Glu Val Asp Leu Ser Gln
1265                1270                1275                1280
Gly Cys Pro Gln Tyr Trp Pro Glu Glu Gly Met Leu Arg Tyr Gly Pro
                1285                1290                1295    
Ile Gln Val Glu Cys Met Ser Cys Ser Met Asp Cys Asp Val Ile Asn
            1300                1305                1310        
Arg Ile Phe Arg Ile Cys Asn Leu Thr Arg Pro Gln Glu Gly Tyr Leu
        1315                1320                1325            
Met Val Gln Gln Phe Gln Tyr Leu Gly Trp Ala Ser His Arg Glu Val
    1330                1335                1340                
Pro Gly Ser Lys Arg Ser Phe Leu Lys Leu Ile Leu Gln Val Glu Lys
1345                1350                1355                1360
Trp Gln Glu Glu Cys Glu Glu Gly Glu Gly Arg Thr Ile Ile His Cys
                1365                1370                1375    
Leu Asn Gly Gly Gly Arg Ser Gly Met Phe Cys Ala Ile Gly Ile Val
            1380                1385                1390        
Val Glu Met Val Lys Arg Gln Asn Val Val Asp Val Phe His Ala Val
        1395                1400                1405            
Lys Thr Leu Arg Asn Ser Lys Pro Asn Met Val Glu Ala Pro Glu Gln
    1410                1415                1420                
Tyr Arg Phe Cys Tyr Asp Val Ala Leu Glu Tyr Leu Glu Ser Ser
1425                1430                1435                


<210> 285
<211> 1280
<212> PRT
<213> Homo sapiens

<400> 285
Met Asp Leu Glu Gly Asp Arg Asn Gly Gly Ala Lys Lys Lys Asn Phe
 1               5                  10                  15      
Phe Lys Leu Asn Asn Lys Ser Glu Lys Asp Lys Lys Glu Lys Lys Pro
            20                  25                  30          
Thr Val Ser Val Phe Ser Met Phe Arg Tyr Ser Asn Trp Leu Asp Lys
        35                  40                  45              
Leu Tyr Met Val Val Gly Thr Leu Ala Ala Ile Ile His Gly Ala Gly
    50                  55                  60                  
Leu Pro Leu Met Met Leu Val Phe Gly Glu Met Thr Asp Ile Phe Ala
65                  70                  75                  80  
Asn Ala Gly Asn Leu Glu Asp Leu Met Ser Asn Ile Thr Asn Arg Ser
                85                  90                  95      
Asp Ile Asn Asp Thr Gly Phe Phe Met Asn Leu Glu Glu Asp Met Thr
            100                 105                 110         
Arg Tyr Ala Tyr Tyr Tyr Ser Gly Ile Gly Ala Gly Val Leu Val Ala
        115                 120                 125             
Ala Tyr Ile Gln Val Ser Phe Trp Cys Leu Ala Ala Gly Arg Gln Ile
    130                 135                 140                 
His Lys Ile Arg Lys Gln Phe Phe His Ala Ile Met Arg Gln Glu Ile
145                 150                 155                 160 
Gly Trp Phe Asp Val His Asp Val Gly Glu Leu Asn Thr Arg Leu Thr
                165                 170                 175     
Asp Asp Val Ser Lys Ile Asn Glu Gly Ile Gly Asp Lys Ile Gly Met
            180                 185                 190         
Phe Phe Gln Ser Met Ala Thr Phe Phe Thr Gly Phe Ile Val Gly Phe
        195                 200                 205             
Thr Arg Gly Trp Lys Leu Thr Leu Val Ile Leu Ala Ile Ser Pro Val
    210                 215                 220                 
Leu Gly Leu Ser Ala Ala Val Trp Ala Lys Ile Leu Ser Ser Phe Thr
225                 230                 235                 240 
Asp Lys Glu Leu Leu Ala Tyr Ala Lys Ala Gly Ala Val Ala Glu Glu
                245                 250                 255     
Val Leu Ala Ala Ile Arg Thr Val Ile Ala Phe Gly Gly Gln Lys Lys
            260                 265                 270         
Glu Leu Glu Arg Tyr Asn Lys Asn Leu Glu Glu Ala Lys Arg Ile Gly
        275                 280                 285             
Ile Lys Lys Ala Ile Thr Ala Asn Ile Ser Ile Gly Ala Ala Phe Leu
    290                 295                 300                 
Leu Ile Tyr Ala Ser Tyr Ala Leu Ala Phe Trp Tyr Gly Thr Thr Leu
305                 310                 315                 320 
Val Leu Ser Gly Glu Tyr Ser Ile Gly Gln Val Leu Thr Val Phe Phe
                325                 330                 335     
Ser Val Leu Ile Gly Ala Phe Ser Val Gly Gln Ala Ser Pro Ser Ile
            340                 345                 350         
Glu Ala Phe Ala Asn Ala Arg Gly Ala Ala Tyr Glu Ile Phe Lys Ile
        355                 360                 365             
Ile Asp Asn Lys Pro Ser Ile Asp Ser Tyr Ser Lys Ser Gly His Lys
    370                 375                 380                 
Pro Asp Asn Ile Lys Gly Asn Leu Glu Phe Arg Asn Val His Phe Ser
385                 390                 395                 400 
Tyr Pro Ser Arg Lys Glu Val Lys Ile Leu Lys Gly Leu Asn Leu Lys
                405                 410                 415     
Val Gln Ser Gly Gln Thr Val Ala Leu Val Gly Asn Ser Gly Cys Gly
            420                 425                 430         
Lys Ser Thr Thr Val Gln Leu Met Gln Arg Leu Tyr Asp Pro Thr Glu
        435                 440                 445             
Gly Met Val Ser Val Asp Gly Gln Asp Ile Arg Thr Ile Asn Val Arg
    450                 455                 460                 
Phe Leu Arg Glu Ile Ile Gly Val Val Ser Gln Glu Pro Val Leu Phe
465                 470                 475                 480 
Ala Thr Thr Ile Ala Glu Asn Ile Arg Tyr Gly Arg Glu Asn Val Thr
                485                 490                 495     
Met Asp Glu Ile Glu Lys Ala Val Lys Glu Ala Asn Ala Tyr Asp Phe
            500                 505                 510         
Ile Met Lys Leu Pro His Lys Phe Asp Thr Leu Val Gly Glu Arg Gly
        515                 520                 525             
Ala Gln Leu Ser Gly Gly Gln Lys Gln Arg Ile Ala Ile Ala Arg Ala
    530                 535                 540                 
Leu Val Arg Asn Pro Lys Ile Leu Leu Leu Asp Glu Ala Thr Ser Ala
545                 550                 555                 560 
Leu Asp Thr Glu Ser Glu Ala Val Val Gln Val Ala Leu Asp Lys Ala
                565                 570                 575     
Arg Lys Gly Arg Thr Thr Ile Val Ile Ala His Arg Leu Ser Thr Val
            580                 585                 590         
Arg Asn Ala Asp Val Ile Ala Gly Phe Asp Asp Gly Val Ile Val Glu
        595                 600                 605             
Lys Gly Asn His Asp Glu Leu Met Lys Glu Lys Gly Ile Tyr Phe Lys
    610                 615                 620                 
Leu Val Thr Met Gln Thr Ala Gly Asn Glu Val Glu Leu Glu Asn Ala
625                 630                 635                 640 
Ala Asp Glu Ser Lys Ser Glu Ile Asp Ala Leu Glu Met Ser Ser Asn
                645                 650                 655     
Asp Ser Arg Ser Ser Leu Ile Arg Lys Arg Ser Thr Arg Arg Ser Val
            660                 665                 670         
Arg Gly Ser Gln Ala Gln Asp Arg Lys Leu Ser Thr Lys Glu Ala Leu
        675                 680                 685             
Asp Glu Ser Ile Pro Pro Val Ser Phe Trp Arg Ile Met Lys Leu Asn
    690                 695                 700                 
Leu Thr Glu Trp Pro Tyr Phe Val Val Gly Val Phe Cys Ala Ile Ile
705                 710                 715                 720 
Asn Gly Gly Leu Gln Pro Ala Phe Ala Ile Ile Phe Ser Lys Ile Ile
                725                 730                 735     
Gly Val Phe Thr Arg Ile Asp Asp Pro Glu Thr Lys Arg Gln Asn Ser
            740                 745                 750         
Asn Leu Phe Ser Leu Leu Phe Leu Ala Leu Gly Ile Ile Ser Phe Ile
        755                 760                 765             
Thr Phe Phe Leu Gln Gly Phe Thr Phe Gly Lys Ala Gly Glu Ile Leu
    770                 775                 780                 
Thr Lys Arg Leu Arg Tyr Met Val Phe Arg Ser Met Leu Arg Gln Asp
785                 790                 795                 800 
Val Ser Trp Phe Asp Asp Pro Lys Asn Thr Thr Gly Ala Leu Thr Thr
                805                 810                 815     
Arg Leu Ala Asn Asp Ala Ala Gln Val Lys Gly Ala Ile Gly Ser Arg
            820                 825                 830         
Leu Ala Val Ile Thr Gln Asn Ile Ala Asn Leu Gly Thr Gly Ile Ile
        835                 840                 845             
Ile Ser Phe Ile Tyr Gly Trp Gln Leu Thr Leu Leu Leu Leu Ala Ile
    850                 855                 860                 
Val Pro Ile Ile Ala Ile Ala Gly Val Val Glu Met Lys Met Leu Ser
865                 870                 875                 880 
Gly Gln Ala Leu Lys Asp Lys Lys Glu Leu Glu Gly Ala Gly Lys Ile
                885                 890                 895     
Ala Thr Glu Ala Ile Glu Asn Phe Arg Thr Val Val Ser Leu Thr Gln
            900                 905                 910         
Glu Gln Lys Phe Glu His Met Tyr Ala Gln Ser Leu Gln Val Pro Tyr
        915                 920                 925             
Arg Asn Ser Leu Arg Lys Ala His Ile Phe Gly Ile Thr Phe Ser Phe
    930                 935                 940                 
Thr Gln Ala Met Met Tyr Phe Ser Tyr Ala Gly Cys Phe Arg Phe Gly
945                 950                 955                 960 
Ala Tyr Leu Val Ala His Lys Leu Met Ser Phe Glu Asp Val Leu Leu
                965                 970                 975     
Val Phe Ser Ala Val Val Phe Gly Ala Met Ala Val Gly Gln Val Ser
            980                 985                 990         
Ser Phe Ala Pro Asp Tyr Ala Lys Ala Lys Ile Ser Ala Ala His Ile
        995                 1000                1005            
Ile Met Ile Ile Glu Lys Thr Pro Leu Ile Asp Ser Tyr Ser Thr Glu
    1010                1015                1020                
Gly Leu Met Pro Asn Thr Leu Glu Gly Asn Val Thr Phe Gly Glu Val
1025                1030                1035                1040
Val Phe Asn Tyr Pro Thr Arg Pro Asp Ile Pro Val Leu Gln Gly Leu
                1045                1050                1055    
Ser Leu Glu Val Lys Lys Gly Gln Thr Leu Ala Leu Val Gly Ser Ser
            1060                1065                1070        
Gly Cys Gly Lys Ser Thr Val Val Gln Leu Leu Glu Arg Phe Tyr Asp
        1075                1080                1085            
Pro Leu Ala Gly Lys Val Leu Leu Asp Gly Lys Glu Ile Lys Arg Leu
    1090                1095                1100                
Asn Val Gln Trp Leu Arg Ala His Leu Gly Ile Val Ser Gln Glu Pro
1105                1110                1115                1120
Ile Leu Phe Asp Cys Ser Ile Ala Glu Asn Ile Ala Tyr Gly Asp Asn
                1125                1130                1135    
Ser Arg Val Val Ser Gln Glu Glu Ile Val Arg Ala Ala Lys Glu Ala
            1140                1145                1150        
Asn Ile His Ala Phe Ile Glu Ser Leu Pro Asn Lys Tyr Ser Thr Lys
        1155                1160                1165            
Val Gly Asp Lys Gly Thr Gln Leu Ser Gly Gly Gln Lys Gln Arg Ile
    1170                1175                1180                
Ala Ile Ala Arg Ala Leu Val Arg Gln Pro His Ile Leu Leu Leu Asp
1185                1190                1195                1200
Glu Ala Thr Ser Ala Leu Asp Thr Glu Ser Glu Lys Val Val Gln Glu
                1205                1210                1215    
Ala Leu Asp Lys Ala Arg Glu Gly Arg Thr Cys Ile Val Ile Ala His
            1220                1225                1230        
Arg Leu Ser Thr Ile Gln Asn Ala Asp Leu Ile Val Val Phe Gln Asn
        1235                1240                1245            
Gly Arg Val Lys Glu His Gly Thr His Gln Gln Leu Leu Ala Gln Lys
    1250                1255                1260                
Gly Ile Tyr Phe Ser Met Val Ser Val Gln Ala Gly Thr Lys Arg Gln
1265                1270                1275                1280


<210> 286
<211> 227
<212> PRT
<213> Homo sapiens

<400> 286
Met Ala Trp Lys Ser Gly Gly Ala Ser His Ser Glu Leu Ile His Asn
 1               5                  10                  15      
Leu Arg Lys Asn Gly Ile Ile Lys Thr Asp Lys Val Phe Glu Val Met
            20                  25                  30          
Leu Ala Thr Asp Arg Ser His Tyr Ala Lys Cys Asn Pro Tyr Met Asp
        35                  40                  45              
Ser Pro Gln Ser Ile Gly Phe Gln Ala Thr Ile Ser Ala Pro His Met
    50                  55                  60                  
His Ala Tyr Ala Leu Glu Leu Leu Phe Asp Gln Leu His Glu Gly Ala
65                  70                  75                  80  
Lys Ala Leu Asp Val Gly Ser Gly Ser Gly Ile Leu Thr Ala Cys Phe
                85                  90                  95      
Ala Arg Met Val Gly Cys Thr Gly Lys Val Ile Gly Ile Asp His Ile
            100                 105                 110         
Lys Glu Leu Val Asp Asp Ser Ile Asn Asn Val Arg Lys Asp Asp Pro
        115                 120                 125             
Thr Leu Leu Ser Ser Gly Arg Val Gln Leu Val Val Gly Asp Gly Arg
    130                 135                 140                 
Met Gly Tyr Ala Glu Glu Ala Pro Tyr Asp Ala Ile His Val Gly Ala
145                 150                 155                 160 
Ala Ala Pro Val Val Pro Gln Ala Leu Ile Asp Gln Leu Lys Pro Gly
                165                 170                 175     
Gly Arg Leu Ile Leu Pro Val Gly Pro Ala Gly Gly Asn Gln Met Leu
            180                 185                 190         
Glu Gln Tyr Asp Lys Leu Gln Asp Gly Ser Ile Lys Met Lys Pro Leu
        195                 200                 205             
Met Gly Val Ile Tyr Val Pro Leu Thr Asp Lys Glu Lys Gln Trp Ser
    210                 215                 220                 
Arg Trp Lys
225         


<210> 287
<211> 315
<212> PRT
<213> Homo sapiens

<400> 287
Met Ala Thr Thr Ala Thr Cys Thr Arg Phe Thr Asp Asp Tyr Gln Leu
 1               5                  10                  15      
Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val
            20                  25                  30          
Lys Lys Thr Ser Thr Gln Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys
        35                  40                  45              
Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile
    50                  55                  60                  
Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile
65                  70                  75                  80  
Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly
                85                  90                  95      
Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp
            100                 105                 110         
Ala Ser His Cys Ile His Gln Ile Leu Glu Ser Val Asn His Ile His
        115                 120                 125             
Gln His Asp Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu
    130                 135                 140                 
Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu
145                 150                 155                 160 
Ala Ile Glu Val Gln Gly Glu Gln Gln Ala Trp Phe Gly Phe Ala Gly
                165                 170                 175     
Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly
            180                 185                 190         
Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu
        195                 200                 205             
Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln
    210                 215                 220                 
Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr
225                 230                 235                 240 
Val Thr Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Thr Ile Asn
                245                 250                 255     
Pro Ala Lys Arg Ile Thr Ala Asp Gln Ala Leu Lys His Pro Trp Val
            260                 265                 270         
Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val
        275                 280                 285             
Glu Cys Leu Arg Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile
    290                 295                 300                 
Leu Thr Thr Met Leu Val Ser Arg Asn Phe Ser
305                 310                 315 


<210> 288
<211> 491
<212> PRT
<213> Homo sapiens

<400> 288
Arg Gln Leu Leu Leu Asp Thr Thr Asp Lys Phe Arg Phe Phe Lys Ala
 1               5                  10                  15      
Val Arg Glu Leu Met Leu Trp Met Asp Glu Val Asn Leu Gln Met Asp
            20                  25                  30          
Ala Gln Glu Arg Pro Arg Asp Val Ser Ser Ala Asp Leu Val Ile Lys
        35                  40                  45              
Asn Gln Gln Gly Ile Lys Ala Glu Ile Glu Ala Arg Ala Asp Arg Phe
    50                  55                  60                  
Ser Ser Cys Ile Asp Met Gly Lys Glu Leu Leu Ala Arg Ser His Tyr
65                  70                  75                  80  
Ala Ala Glu Glu Ile Ser Glu Lys Leu Ser Gln Leu Gln Ala Arg Arg
                85                  90                  95      
Gln Glu Thr Ala Glu Lys Trp Gln Glu Lys Met Asp Trp Leu Gln Leu
            100                 105                 110         
Val Leu Glu Val Leu Val Phe Gly Arg Asp Ala Gly Met Ala Glu Ala
        115                 120                 125             
Trp Leu Cys Ser Gln Glu Pro Leu Val Arg Ser Ala Glu Leu Gly Cys
    130                 135                 140                 
Thr Val Asp Glu Val Glu Ser Leu Ile Lys Arg His Glu Ala Phe Gln
145                 150                 155                 160 
Lys Ser Ala Val Ala Trp Glu Glu Arg Phe Cys Ala Leu Glu Lys Leu
                165                 170                 175     
Thr Ala Leu Glu Glu Arg Glu Lys Glu Arg Lys Arg Lys Arg Glu Glu
            180                 185                 190         
Glu Glu Arg Arg Lys Gln Pro Pro Ala Pro Glu Pro Thr Ala Ser Val
        195                 200                 205             
Pro Pro Gly Asp Leu Val Gly Gly Gln Thr Ala Ser Asp Thr Thr Trp
    210                 215                 220                 
Asp Gly Thr Gln Pro Arg Pro Pro Pro Ser Thr Gln Ala Pro Ser Val
225                 230                 235                 240 
Asn Gly Val Cys Thr Asp Gly Glu Pro Ser Gln Pro Leu Leu Gly Gln
                245                 250                 255     
Gln Arg Leu Glu His Ser Ser Phe Pro Glu Gly Pro Gly Pro Gly Ser
            260                 265                 270         
Gly Asp Glu Ala Asn Gly Pro Arg Gly Glu Arg Gln Thr Arg Thr Arg
        275                 280                 285             
Gly Pro Ala Pro Ser Ala Met Pro Gln Ser Arg Ser Thr Glu Ser Ala
    290                 295                 300                 
His Ala Ala Thr Leu Pro Pro Arg Gly Pro Glu Pro Ser Ala Gln Glu
305                 310                 315                 320 
Gln Met Glu Gly Met Leu Cys Arg Lys Gln Glu Met Glu Ala Phe Gly
                325                 330                 335     
Lys Lys Ala Ala Asn Arg Ser Trp Gln Asn Val Tyr Cys Val Leu Arg
            340                 345                 350         
Arg Gly Ser Leu Gly Phe Tyr Lys Asp Ala Lys Ala Ala Ser Ala Gly
        355                 360                 365             
Val Pro Tyr His Gly Glu Val Pro Val Ser Leu Ala Arg Ala Gln Gly
    370                 375                 380                 
Ser Val Ala Phe Asp Tyr Arg Lys Arg Lys His Val Phe Lys Leu Gly
385                 390                 395                 400 
Leu Gln Asp Gly Lys Glu Tyr Leu Phe Gln Ala Lys Asp Glu Ala Glu
                405                 410                 415     
Met Ser Ser Trp Leu Arg Val Val Asn Ala Ala Ile Ala Thr Ala Ser
            420                 425                 430         
Ser Ala Ser Gly Glu Pro Glu Glu Pro Val Val Pro Ser Thr Thr Arg
        435                 440                 445             
Gly Met Thr Arg Ala Met Thr Met Pro Pro Val Ser Pro Val Gly Ala
    450                 455                 460                 
Glu Gly Pro Val Val Leu Arg Ser Lys Asp Gly Arg Glu Arg Glu Arg
465                 470                 475                 480 
Glu Lys Arg Phe Ser Phe Phe Lys Lys Asn Lys
                485                 490     


<210> 289
<211> 372
<212> PRT
<213> Homo sapiens

<400> 289
Met Ala Ser Asn Glu Asp Phe Ser Ile Thr Gln Asp Leu Glu Ile Pro
 1               5                  10                  15      
Ala Asp Ile Val Glu Leu His Asp Ile Asn Val Glu Pro Leu Pro Met
            20                  25                  30          
Glu Asp Ile Pro Thr Glu Ser Val Gln Tyr Glu Asp Val Asp Gly Asn
        35                  40                  45              
Trp Ile Tyr Gly Gly His Asn His Pro Pro Leu Met Val Leu Gln Pro
    50                  55                  60                  
Leu Phe Thr Asn Thr Gly Tyr Gly Asp His Asp Gln Glu Met Leu Met
65                  70                  75                  80  
Leu Gln Thr Gln Glu Glu Val Val Gly Tyr Cys Asp Ser Asp Asn Gln
                85                  90                  95      
Leu Gly Asn Asp Leu Glu Asp Gln Leu Ala Leu Pro Asp Ser Ile Glu
            100                 105                 110         
Asp Glu His Phe Gln Met Thr Leu Ala Ser Leu Ser Ala Ser Ala Ala
        115                 120                 125             
Ser Thr Ser Thr Ser Thr Gln Ser Arg Ser Lys Lys Pro Ser Lys Lys
    130                 135                 140                 
Pro Ser Gly Lys Ser Ala Thr Ser Thr Glu Ala Asn Pro Ala Gly Ser
145                 150                 155                 160 
Ser Ser Ser Leu Gly Thr Arg Lys Trp Glu Gln Lys Gln Met Gln Val
                165                 170                 175     
Lys Thr Leu Glu Gly Glu Phe Ser Val Thr Met Trp Ser Pro Asn Asp
            180                 185                 190         
Asn Asn Asp Gln Gly Ala Val Gly Glu Gly Gln Ala Glu Asn Pro Pro
        195                 200                 205             
Asp Tyr Ser Glu Tyr Leu Lys Gly Lys Lys Leu Pro Pro Gly Gly Leu
    210                 215                 220                 
Pro Gly Ile Asp Leu Ser Asp Pro Lys Gln Leu Ala Glu Phe Thr Lys
225                 230                 235                 240 
Val Lys Pro Lys Arg Ser Lys Gly Glu Pro Pro Lys Thr Val Pro Cys
                245                 250                 255     
Ser Tyr Ser Gly Cys Glu Lys Met Phe Arg Asp Tyr Ala Ala Met Arg
            260                 265                 270         
Lys His Leu His Ile His Gly Pro Arg Val His Val Cys Ala Glu Cys
        275                 280                 285             
Gly Lys Ala Phe Leu Glu Ser Ser Lys Leu Arg Arg His Gln Leu Val
    290                 295                 300                 
His Thr Gly Glu Lys Pro Phe Gln Cys Thr Phe Glu Gly Cys Gly Lys
305                 310                 315                 320 
Arg Phe Ser Leu Asp Phe Asn Leu Arg Thr His Leu Arg Ile His Thr
                325                 330                 335     
Gly Asp Lys Pro Phe Val Cys Pro Phe Asp Val Cys Asn Arg Lys Phe
            340                 345                 350         
Ala Gln Ser Thr Asn Leu Lys Thr His Ile Leu Thr His Val Lys Thr
        355                 360                 365             
Lys Asn Asn Pro
    370         


<210> 290
<211> 132
<212> PRT
<213> Homo sapiens

<400> 290
Glu Ser Glu Thr Thr Thr Ser Leu Val Leu Glu Arg Ser Leu Asn Arg
 1               5                  10                  15      
Val His Leu Leu Gly Arg Val Gly Gln Asp Pro Val Leu Arg Gln Val
            20                  25                  30          
Glu Gly Lys Asn Pro Val Thr Ile Phe Ser Leu Ala Thr Asn Glu Met
        35                  40                  45              
Trp Arg Ser Gly Asp Ser Glu Val Tyr Gln Leu Gly Asp Val Ser Gln
    50                  55                  60                  
Lys Thr Thr Trp His Arg Ile Ser Val Phe Arg Pro Gly Leu Arg Asp
65                  70                  75                  80  
Val Ala Tyr Gln Tyr Val Lys Lys Gly Ser Arg Ile Tyr Leu Glu Gly
                85                  90                  95      
Lys Ile Asp Tyr Gly Glu Tyr Met Asp Lys Asn Asn Val Arg Arg Gln
            100                 105                 110         
Ala Thr Thr Ile Ile Ala Asp Asn Ile Ile Phe Leu Ser Asp Gln Thr
        115                 120                 125             
Lys Glu Lys Glu
    130         


<210> 291
<211> 481
<212> PRT
<213> Homo sapiens

<400> 291
Met Gly Ala Leu Ala Arg Ala Leu Pro Ser Ile Leu Leu Ala Leu Leu
 1               5                  10                  15      
Leu Thr Ser Thr Pro Glu Ala Leu Gly Ala Asn Pro Gly Leu Val Ala
            20                  25                  30          
Arg Ile Thr Asp Lys Gly Leu Gln Tyr Ala Ala Gln Glu Gly Leu Leu
        35                  40                  45              
Ala Leu Gln Ser Glu Leu Leu Arg Ile Thr Leu Pro Asp Phe Thr Gly
    50                  55                  60                  
Asp Leu Arg Ile Pro His Val Gly Arg Gly Arg Tyr Glu Phe His Ser
65                  70                  75                  80  
Leu Lys Ile His Ser Cys Glu Leu Leu His Ser Ala Leu Arg Pro Val
                85                  90                  95      
Pro Gly Gln Gly Leu Ser Leu Ser Ile Ser Asp Ser Ser Ile Arg Val
            100                 105                 110         
Gln Gly Arg Trp Lys Val Arg Lys Ser Phe Phe Lys Leu Gln Gly Phe
        115                 120                 125             
Phe Asp Val Ser Val Lys Gly Ile Ser Ile Ser Val Asn Leu Leu Leu
    130                 135                 140                 
Gly Ser Glu Ser Ser Gly Arg Pro Thr Val Thr Ala Ser Ser Cys Ser
145                 150                 155                 160 
Ser Asp Ile Ala Asp Val Glu Val Asp Met Ser Gly Asp Leu Gly Trp
                165                 170                 175     
Leu Leu Asn Leu Phe His Asn Gln Ile Glu Ser Lys Phe Gln Lys Val
            180                 185                 190         
Leu Glu Ser Arg Ile Cys Glu Met Ile Gln Lys Ser Val Ser Ser Asp
        195                 200                 205             
Leu Gln Pro Tyr Leu Gln Thr Leu Pro Val Thr Thr Glu Ile Asp Ser
    210                 215                 220                 
Phe Ala Asp Ile Asp Tyr Ser Leu Val Glu Ala Pro Arg Ala Thr Ala
225                 230                 235                 240 
Gln Met Leu Glu Val Met Phe Lys Gly Glu Ile Phe His Arg Asn His
                245                 250                 255     
Ser Ser Pro Val Thr Leu Leu Ala Ala Val Met Ser Leu Pro Glu Glu
            260                 265                 270         
His Asn Lys Met Val Tyr Phe Ala Ile Ser Asp Tyr Val Phe Asn Thr
        275                 280                 285             
Ala Ser Leu Val Tyr His Glu Glu Gly Tyr Leu Asn Phe Ser Ile Thr
    290                 295                 300                 
Asp Asp Met Ile Pro Pro Asp Ser Asn Ile Arg Leu Thr Thr Lys Ser
305                 310                 315                 320 
Phe Arg Pro Phe Val Pro Arg Leu Ala Arg Leu Tyr Pro Asn Met Asn
                325                 330                 335     
Leu Glu Leu Gln Gly Ser Val Pro Ser Ala Pro Leu Leu Asn Phe Ser
            340                 345                 350         
Pro Gly Asn Leu Ser Val Asp Pro Tyr Met Glu Ile Asp Ala Phe Val
        355                 360                 365             
His Leu Pro Ser Ser Ser Lys Glu Pro Val Phe Arg Leu Ser Val Ala
    370                 375                 380                 
Thr Asn Val Ser Ala Thr Leu Thr Phe Asn Thr Ser Lys Ile Thr Gly
385                 390                 395                 400 
Phe Leu Lys Pro Gly Lys Val Lys Val Glu Leu Lys Glu Ser Lys Val
                405                 410                 415     
Gly Leu Phe Asn Ala Glu Leu Leu Glu Ala Leu Leu Asn Tyr Tyr Ile
            420                 425                 430         
Leu Asn Thr Phe Tyr Pro Lys Phe Asn Asp Lys Leu Ala Glu Gly Phe
        435                 440                 445             
Pro Leu Pro Leu Leu Lys Arg Val Gln Leu Tyr Asp Leu Gly Leu Gln
    450                 455                 460                 
Ile His Lys Asp Phe Leu Phe Leu Gly Ala Asn Val Gln Tyr Met Arg
465                 470                 475                 480 
Val
    


<210> 292
<211> 317
<212> PRT
<213> Homo sapiens

<400> 292
Met Trp Leu Tyr Leu Ala Ala Phe Val Gly Leu Tyr Tyr Leu Leu His
 1               5                  10                  15      
Trp Tyr Arg Glu Arg Gln Val Val Ser His Leu Gln Asp Lys Tyr Val
            20                  25                  30          
Phe Ile Thr Gly Cys Asp Ser Gly Phe Gly Asn Leu Leu Ala Arg Gln
        35                  40                  45              
Leu Asp Ala Arg Gly Leu Arg Val Leu Ala Ala Cys Leu Thr Asp Lys
    50                  55                  60                  
Gly Ala Glu Gln Leu Arg Gly Gln Thr Ser Asp Arg Leu Glu Thr Val
65                  70                  75                  80  
Thr Leu Asp Val Thr Lys Met Glu Ser Ile Ala Ala Ala Thr Gln Trp
                85                  90                  95      
Val Lys Glu His Val Gly Asp Arg Arg Leu Trp Gly Leu Val Asn Asn
            100                 105                 110         
Ala Gly Ile Leu Thr Pro Ile Thr Leu Cys Glu Trp Leu Asn Thr Glu
        115                 120                 125             
Asp Ser Met Asn Met Leu Lys Val Asn Leu Ile Gly Val Ile Gln Val
    130                 135                 140                 
Thr Leu Ser Met Leu Pro Leu Val Arg Arg Ala Arg Gly Lys Asn Cys
145                 150                 155                 160 
Gln Cys Leu Gln His Ser Gly Lys Ser Cys Phe Leu Cys Arg Gly Tyr
                165                 170                 175     
Cys Val Ser Lys Tyr Gly Val Glu Ala Phe Ser Asp Ile Leu Arg Arg
            180                 185                 190         
Glu Ile Gln His Phe Gly Val Lys Ile Ser Ile Val Glu Pro Gly Tyr
        195                 200                 205             
Phe Arg Thr Gly Met Thr Asn Met Thr Gln Ser Leu Glu Arg Met Lys
    210                 215                 220                 
Gln Ser Trp Lys Glu Ala Pro Lys His Ile Lys Glu Thr Tyr Gly Gln
225                 230                 235                 240 
Gln Tyr Phe Asp Ala Leu Tyr Asn Ile Met Lys Glu Gly Leu Leu Asn
                245                 250                 255     
Cys Ser Thr Asn Leu Asn Leu Val Thr Asp Cys Met Glu His Ala Leu
            260                 265                 270         
Thr Ser Val His Pro Arg Thr Arg Tyr Ser Ala Gly Trp Asp Ala Lys
        275                 280                 285             
Phe Phe Phe Ile Pro Leu Ser Tyr Leu Pro Thr Ser Leu Ala Asp Tyr
    290                 295                 300                 
Ile Leu Thr Arg Ser Trp Pro Lys Pro Ala Gln Ala Val
305                 310                 315         


<210> 293
<211> 410
<212> PRT
<213> Homo sapiens

<400> 293
Met Gly Pro Gln Ile Phe His Lys Thr Ser Glu Leu Phe Leu Pro Ala
 1               5                  10                  15      
Thr Ser Cys Pro Ser Cys Pro Asp Gln Asn Glu Glu Asp Val Ser Gln
            20                  25                  30          
Thr Gln Tyr Lys Glu Cys Cys Gly Gly Gly Trp Cys Ser His Ser Ile
        35                  40                  45              
Phe Ala Val Trp His Phe Ala Ala Leu Gly Ala Gly Phe Ser Asp Lys
    50                  55                  60                  
Thr Pro Ala His Thr Val Thr Met Ala Cys Ile Ser Ala Asn Gln Ala
65                  70                  75                  80  
Met Thr Thr Gly Val Gly Leu Ile Ala Ser Gly Gln Cys Asp Val Ile
                85                  90                  95      
Val Ala Gly Gly Val Glu Leu Met Ser Asp Val Pro Ile Arg His Ser
            100                 105                 110         
Arg Lys Met Arg Lys Leu Met Leu Asp Leu Asn Lys Ala Lys Ser Met
        115                 120                 125             
Gly Gln Arg Leu Ser Leu Ile Ser Lys Phe Arg Phe Asn Phe Leu Ala
    130                 135                 140                 
Pro Glu Leu Pro Ala Val Ser Glu Phe Ser Thr Ser Glu Thr Met Gly
145                 150                 155                 160 
His Ser Ala Asp Arg Leu Ala Ala Ala Phe Ala Val Ser Arg Leu Glu
                165                 170                 175     
Gln Asp Glu Tyr Ala Leu Arg Ser His Ser Leu Ala Lys Lys Ala Gln
            180                 185                 190         
Asp Glu Gly Leu Leu Ser Asp Val Val Pro Phe Lys Val Pro Gly Lys
        195                 200                 205             
Asp Thr Val Thr Lys Asp Asn Gly Ile Arg Pro Ser Ser Leu Glu Gln
    210                 215                 220                 
Met Ala Lys Leu Lys Pro Ala Phe Ile Lys Pro Tyr Gly Thr Val Thr
225                 230                 235                 240 
Ala Ala Asn Ser Ser Phe Leu Thr Asp Gly Ala Ser Ala Met Leu Ile
                245                 250                 255     
Met Ala Glu Glu Lys Ala Leu Ala Met Gly Tyr Lys Pro Lys Ala Tyr
            260                 265                 270         
Leu Arg Asp Phe Met Tyr Val Ser Gln Asp Pro Lys Asp Gln Leu Leu
        275                 280                 285             
Leu Gly Pro Thr Tyr Ala Thr Pro Lys Val Leu Glu Lys Ala Gly Leu
    290                 295                 300                 
Thr Met Asn Asp Ile Asp Ala Phe Glu Phe His Glu Ala Phe Ser Gly
305                 310                 315                 320 
Gln Ile Leu Ala Asn Phe Lys Ala Met Asp Ser Asp Trp Phe Ala Glu
                325                 330                 335     
Asn Tyr Met Gly Arg Lys Thr Lys Val Gly Leu Pro Pro Leu Glu Lys
            340                 345                 350         
Phe Asn Asn Trp Gly Gly Ser Leu Ser Leu Gly His Pro Phe Gly Ala
        355                 360                 365             
Thr Gly Cys Arg Leu Val Met Ala Ala Ala Asn Arg Leu Arg Lys Glu
    370                 375                 380                 
Gly Gly Gln Tyr Gly Leu Val Ala Ala Cys Ala Ala Gly Gly Gln Gly
385                 390                 395                 400 
His Ala Met Ile Val Glu Ala Tyr Pro Lys
                405                 410 


<210> 294
<211> 1366
<212> PRT
<213> Homo sapiens

<400> 294
Met Ala Gln Ala Leu Leu Val Pro Pro Gly Pro Glu Ser Phe Arg Leu
 1               5                  10                  15      
Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Ala Ala Glu Glu
            20                  25                  30          
Lys Ala Lys Lys Pro Lys Lys Glu Gln Asp Asn Asp Asp Glu Asn Lys
        35                  40                  45              
Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile
    50                  55                  60                  
Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu
65                  70                  75                  80  
Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Met Asn Lys Gly
                85                  90                  95      
Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr
            100                 105                 110         
Pro Leu Asn Pro Val Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser
        115                 120                 125             
Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe
    130                 135                 140                 
Met Thr Leu Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr
145                 150                 155                 160 
Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Val Arg
                165                 170                 175     
Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp
            180                 185                 190         
Leu Asp Phe Ser Val Ile Val Met Ala Tyr Val Thr Glu Phe Val Ser
        195                 200                 205             
Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu
    210                 215                 220                 
Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu
225                 230                 235                 240 
Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe
                245                 250                 255     
Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn
            260                 265                 270         
Leu Arg Asn Lys Cys Leu Gln Trp Pro Pro Ser Asp Ser Ala Phe Glu
        275                 280                 285             
Thr Asn Thr Thr Ser Tyr Phe Asn Gly Thr Met Asp Ser Asn Gly Thr
    290                 295                 300                 
Phe Val Asn Val Thr Met Ser Thr Phe Asn Trp Lys Asp Asn Ile Gly
305                 310                 315                 320 
Asp Asp Ser His Phe Tyr Val Leu Asp Gly Gln Lys Asp Pro Leu Leu
                325                 330                 335     
Cys Gly Asn Gly Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Ile Cys
            340                 345                 350         
Val Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr
        355                 360                 365             
Phe Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Tyr
    370                 375                 380                 
Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr
385                 390                 395                 400 
Thr Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Val
                405                 410                 415     
Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln
            420                 425                 430         
Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met
        435                 440                 445             
Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala Val Ala Ala
    450                 455                 460                 
Ala Ser Ala Ala Ser Arg Asp Phe Ser Gly Ile Gly Gly Leu Gly Glu
465                 470                 475                 480 
Leu Leu Glu Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala
                485                 490                 495     
Lys Glu Trp Arg Asn Arg Arg Lys Lys Arg Arg Gln Arg Glu His Leu
            500                 505                 510         
Glu Gly Asn Asn Lys Gly Glu Arg Asp Ser Phe Pro Lys Ser Glu Ser
        515                 520                 525             
Glu Asp Ser Val Lys Arg Ser Ser Phe Leu Phe Ser Met Asp Gly Asn
    530                 535                 540                 
Arg Leu Thr Ser Asp Lys Lys Phe Cys Ser Pro His Gln Ser Leu Leu
545                 550                 555                 560 
Ser Ile Arg Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Lys Thr Ser
                565                 570                 575     
Ile Phe Ser Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp
            580                 585                 590         
Phe Ala Asp Asp Glu His Ser Thr Phe Glu Asp Ser Glu Thr Arg Arg
        595                 600                 605             
Asp Ser Leu Phe Glu Pro His Arg His Gly Glu Arg Arg Asn Ser Asn
    610                 615                 620                 
Gly Thr Thr Thr Glu Thr Glu Val Arg Lys Arg Arg Leu Ser Ser Tyr
625                 630                 635                 640 
Gln Ile Ser Met Glu Met Leu Glu Asp Ser Ser Gly Arg Gln Arg Ala
                645                 650                 655     
Val Ser Ile Ala Ser Ile Leu Thr Asn Thr Met Glu Glu Leu Glu Glu
            660                 665                 670         
Ser Arg Gln Lys Cys Pro Pro Cys Trp Tyr Arg Phe Ala Asn Val Phe
        675                 680                 685             
Leu Ile Trp Asp Cys Cys Asp Ala Trp Leu Lys Val Lys His Leu Val
    690                 695                 700                 
Asn Leu Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys
705                 710                 715                 720 
Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met Thr
                725                 730                 735     
Glu Gln Phe Ser Ser Val Leu Thr Val Gly Asn Leu Val Phe Thr Gly
            740                 745                 750         
Ile Phe Thr Ala Glu Met Val Leu Lys Ile Ile Ala Met Asp Pro Tyr
        755                 760                 765             
Tyr Tyr Phe Gln Glu Gly Trp Asn Ile Phe Asp Gly Ile Ile Val Ser
    770                 775                 780                 
Leu Ser Leu Met Glu Leu Gly Leu Ser Asn Val Glu Gly Leu Ser Val
785                 790                 795                 800 
Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp
                805                 810                 815     
Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala
            820                 825                 830         
Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala
        835                 840                 845             
Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys
    850                 855                 860                 
Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg Trp His Met Asn Asp Phe
865                 870                 875                 880 
Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile
                885                 890                 895     
Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys Leu
            900                 905                 910         
Ile Val Phe Met Leu Val Met Val Ile Gly Asn Leu Val Val Leu Asn
        915                 920                 925             
Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu Ala
    930                 935                 940                 
Ala Thr Asp Asp Asp Asn Glu Met Asn Asn Leu Gln Ile Ala Val Gly
945                 950                 955                 960 
Arg Met Gln Lys Gly Ile Asp Tyr Val Lys Asn Lys Met Arg Glu Cys
                965                 970                 975     
Phe Gln Lys Ala Phe Phe Arg Lys Pro Lys Val Ile Glu Ile His Glu
            980                 985                 990         
Gly Asn Lys Ile Asp Ser Cys Met Ser Asn Asn Thr Gly Ile Glu Ile
        995                 1000                1005            
Ser Lys Ala Leu Asn Tyr Leu Arg Asp Gly Asn Gly Thr Thr Ser Gly
    1010                1015                1020                
Val Gly Thr Gly Ser Ser Val Glu Lys Tyr Val Ile Asp Glu Asn Asp
1025                1030                1035                1040
Tyr Met Ser Phe Ile Asn Asn Pro Ser Leu Thr Val Thr Val Pro Ile
                1045                1050                1055    
Ala Val Gly Glu Ser Asp Phe Glu Asn Leu Asn Thr Glu Glu Phe Ser
            1060                1065                1070        
Ser Glu Ser Glu Leu Glu Glu Ser Lys Glu Lys Leu Asn Ala Thr Ser
        1075                1080                1085            
Ser Ser Glu Gly Ser Thr Val Asp Val Val Leu Pro Arg Glu Gly Glu
    1090                1095                1100                
Gln Ala Glu Thr Glu Pro Glu Glu Asp Leu Lys Pro Glu Ala Cys Phe
1105                1110                1115                1120
Thr Glu Gly Cys Ile Lys Lys Phe Pro Phe Cys Gln Val Ser Thr Glu
                1125                1130                1135    
Glu Gly Lys Gly Lys Ile Trp Trp Asn Leu Arg Lys Thr Cys Tyr Ser
            1140                1145                1150        
Ile Val Glu His Asn Trp Phe Glu Thr Phe Ile Val Phe Met Ile Leu
        1155                1160                1165            
Leu Ser Ser Gly Ala Leu Ala Phe Glu Asp Ile Tyr Ile Glu Gln Arg
    1170                1175                1180                
Lys Thr Ile Lys Thr Met Leu Glu Tyr Ala Asp Lys Val Phe Thr Tyr
1185                1190                1195                1200
Ile Phe Ile Leu Glu Met Leu Leu Lys Trp Val Ala Tyr Gly Phe Gln
                1205                1210                1215    
Thr Tyr Phe Thr Asn Ala Trp Cys Arg Leu Asp Phe Leu Ile Val Asp
            1220                1225                1230        
Val Ser Leu Val Ser Leu Val Ala Asn Ala Leu Gly Tyr Ser Glu Leu
        1235                1240                1245            
Gly Ala Ile Lys Ser Leu Arg Thr Leu Arg Ala Leu Arg Pro Leu Arg
    1250                1255                1260                
Ala Leu Ser Arg Phe Glu Gly Met Arg Val Val Val Asn Ala Leu Val
1265                1270                1275                1280
Gly Ala Ile Pro Ser Ile Met Asn Val Leu Leu Val Cys Leu Ile Phe
                1285                1290                1295    
Trp Leu Ile Phe Ser Ile Met Gly Val Asn Leu Phe Ala Gly Lys Phe
            1300                1305                1310        
Tyr His Cys Val Asn Met Thr Thr Gly Asn Met Phe Asp Ile Ser Asp
        1315                1320                1325            
Val Asn Asn Leu Ser Asp Cys Gln Ala Leu Gly Lys Gln Ala Arg Trp
    1330                1335                1340                
Lys Asn Val Lys Val Asn Phe Asp Asn Val Gly Ala Gly Tyr Leu Ala
1345                1350                1355                1360
Leu Leu Gln Val Val Ser
                1365    


<210> 295
<211> 1223
<212> PRT
<213> Homo sapiens

<400> 295
Met Lys Asp Ser Cys Ile Thr Val Met Ala Met Ala Leu Leu Ser Gly
 1               5                  10                  15      
Phe Phe Phe Phe Ala Pro Ala Ser Ser Tyr Asn Leu Asp Val Arg Gly
            20                  25                  30          
Ala Arg Ser Phe Ser Pro Pro Arg Ala Gly Arg His Phe Gly Tyr Arg
        35                  40                  45              
Val Leu Gln Val Gly Asn Gly Val Ile Val Gly Ala Pro Gly Glu Gly
    50                  55                  60                  
Asn Ser Thr Gly Ser Leu Tyr Gln Cys Gln Ser Gly Thr Gly His Cys
65                  70                  75                  80  
Leu Pro Val Thr Leu Arg Gly Ser Asn Tyr Thr Ser Lys Tyr Leu Gly
                85                  90                  95      
Met Thr Leu Ala Thr Asp Pro Thr Asp Gly Ser Ile Leu Ala Cys Asp
            100                 105                 110         
Pro Gly Leu Ser Arg Thr Cys Asp Gln Asn Thr Tyr Leu Ser Gly Leu
        115                 120                 125             
Cys Tyr Leu Phe Arg Gln Asn Leu Gln Gly Pro Met Leu Gln Gly Arg
    130                 135                 140                 
Pro Gly Phe Gln Glu Cys Ile Lys Gly Asn Val Asp Leu Val Phe Leu
145                 150                 155                 160 
Phe Asp Gly Ser Met Ser Leu Gln Pro Asp Glu Phe Gln Lys Ile Leu
                165                 170                 175     
Asp Phe Met Lys Asp Val Met Lys Lys Leu Ser Asn Thr Ser Tyr Gln
            180                 185                 190         
Phe Ala Ala Val Gln Phe Ser Thr Ser Tyr Lys Thr Glu Phe Asp Phe
        195                 200                 205             
Ser Asp Tyr Val Lys Trp Lys Asp Pro Asp Ala Leu Leu Lys His Val
    210                 215                 220                 
Lys His Met Leu Leu Leu Thr Asn Thr Phe Gly Ala Ile Asn Tyr Val
225                 230                 235                 240 
Ala Thr Glu Val Phe Arg Glu Glu Leu Gly Ala Arg Pro Asp Ala Thr
                245                 250                 255     
Lys Val Leu Ile Ile Ile Thr Asp Gly Glu Ala Thr Asp Ser Gly Asn
            260                 265                 270         
Ile Asp Ala Ala Lys Asp Ile Ile Arg Tyr Ile Ile Gly Ile Gly Lys
        275                 280                 285             
His Phe Gln Thr Lys Glu Ser Gln Glu Thr Leu His Lys Phe Ala Ser
    290                 295                 300                 
Lys Pro Ala Ser Glu Phe Val Lys Ile Leu Asp Thr Phe Glu Lys Leu
305                 310                 315                 320 
Lys Asp Leu Phe Thr Glu Leu Gln Lys Lys Ile Tyr Val Ile Glu Gly
                325                 330                 335     
Thr Ser Lys Gln Asp Leu Thr Ser Phe Asn Met Glu Leu Ser Ser Ser
            340                 345                 350         
Gly Ile Ser Ala Asp Leu Ser Arg Gly His Ala Val Val Gly Ala Val
        355                 360                 365             
Gly Ala Lys Asp Trp Ala Gly Gly Phe Leu Asp Leu Lys Ala Asp Leu
    370                 375                 380                 
Gln Asp Asp Thr Phe Ile Gly Asn Glu Pro Leu Thr Pro Glu Val Arg
385                 390                 395                 400 
Ala Gly Tyr Leu Gly Tyr Thr Val Thr Trp Leu Pro Ser Arg Gln Lys
                405                 410                 415     
Thr Ser Leu Leu Ala Ser Gly Ala Pro Arg Tyr Gln His Met Gly Arg
            420                 425                 430         
Val Leu Leu Phe Gln Glu Pro Gln Gly Gly Gly His Trp Ser Gln Val
        435                 440                 445             
Gln Thr Ile His Gly Thr Gln Ile Gly Ser Tyr Phe Gly Gly Glu Leu
    450                 455                 460                 
Cys Gly Val Asp Val Asp Gln Asp Gly Glu Thr Glu Leu Leu Leu Ile
465                 470                 475                 480 
Gly Ala Pro Leu Phe Tyr Gly Glu Gln Arg Gly Gly Arg Val Phe Ile
                485                 490                 495     
Tyr Gln Arg Arg Gln Leu Gly Phe Glu Glu Val Ser Glu Leu Gln Gly
            500                 505                 510         
Asp Pro Gly Tyr Pro Leu Gly Arg Phe Gly Glu Ala Ile Thr Ala Leu
        515                 520                 525             
Thr Asp Ile Asn Gly Asp Gly Leu Val Asp Val Ala Val Gly Ala Pro
    530                 535                 540                 
Leu Glu Glu Gln Gly Ala Val Tyr Ile Phe Asn Gly Arg His Gly Gly
545                 550                 555                 560 
Leu Ser Pro Gln Pro Ser Gln Arg Ile Glu Gly Thr Gln Val Leu Ser
                565                 570                 575     
Gly Ile Gln Trp Phe Gly Arg Ser Ile His Gly Val Lys Asp Leu Glu
            580                 585                 590         
Gly Asp Gly Leu Ala Asp Val Ala Val Gly Ala Glu Ser Gln Met Ile
        595                 600                 605             
Val Leu Ser Ser Arg Pro Val Val Asp Met Val Thr Leu Met Ser Phe
    610                 615                 620                 
Ser Pro Ala Glu Ile Pro Val His Glu Val Glu Cys Ser Tyr Ser Thr
625                 630                 635                 640 
Ser Asn Lys Met Lys Glu Gly Val Asn Ile Thr Ile Cys Phe Gln Ile
                645                 650                 655     
Lys Ser Leu Ile Pro Gln Phe Gln Gly Arg Leu Val Ala Asn Leu Thr
            660                 665                 670         
Tyr Thr Leu Gln Leu Asp Gly His Arg Thr Arg Arg Arg Gly Leu Phe
        675                 680                 685             
Pro Gly Gly Arg His Glu Leu Arg Arg Asn Ile Ala Val Thr Thr Ser
    690                 695                 700                 
Met Ser Cys Thr Asp Phe Ser Phe His Phe Pro Val Cys Val Gln Asp
705                 710                 715                 720 
Leu Ile Ser Pro Ile Asn Val Ser Leu Asn Phe Ser Leu Trp Glu Glu
                725                 730                 735     
Glu Gly Thr Pro Arg Asp Gln Arg Ala Gln Gly Lys Asp Ile Pro Pro
            740                 745                 750         
Ile Leu Arg Pro Ser Leu His Ser Glu Thr Trp Glu Ile Pro Phe Glu
        755                 760                 765             
Lys Asn Cys Gly Glu Asp Lys Lys Cys Glu Ala Asn Leu Arg Val Ser
    770                 775                 780                 
Phe Ser Pro Ala Arg Ser Arg Ala Leu Arg Leu Thr Ala Phe Ala Ser
785                 790                 795                 800 
Leu Ser Val Glu Leu Ser Leu Ser Asn Leu Glu Glu Asp Ala Tyr Trp
                805                 810                 815     
Val Gln Leu Asp Leu His Phe Pro Pro Gly Leu Ser Phe Arg Lys Val
            820                 825                 830         
Glu Met Leu Lys Pro His Ser Gln Ile Pro Val Ser Cys Glu Glu Leu
        835                 840                 845             
Pro Glu Glu Ser Arg Leu Leu Ser Arg Ala Leu Ser Cys Asn Val Ser
    850                 855                 860                 
Ser Pro Ile Phe Lys Ala Gly His Ser Val Ala Leu Gln Met Met Phe
865                 870                 875                 880 
Asn Thr Leu Val Asn Ser Ser Trp Gly Asp Ser Val Glu Leu His Ala
                885                 890                 895     
Asn Val Thr Cys Asn Asn Glu Asp Ser Asp Leu Leu Glu Asp Asn Ser
            900                 905                 910         
Ala Thr Thr Ile Ile Pro Ile Leu Tyr Pro Ile Asn Ile Leu Ile Gln
        915                 920                 925             
Asp Gln Glu Asp Ser Thr Leu Tyr Val Ser Phe Thr Pro Lys Gly Pro
    930                 935                 940                 
Lys Ile His Gln Val Lys His Met Tyr Gln Gly Val His Gly Leu Val
945                 950                 955                 960 
Glu Met Gln Thr Ser Lys Gln Ile Leu Cys Arg Pro Ala Gly Asp Ala
                965                 970                 975     
Glu His Thr Val Gly Ala Gln Glu Gly Glu Leu Pro Cys Pro Trp Gly
            980                 985                 990         
Val Ser Glu Ala Phe Arg Asp Asn Ile Arg Ala Gly Pro Cys Arg Val
        995                 1000                1005            
Arg Ile Gln Pro Ser Ile His Asp His Asn Ile Pro Thr Leu Glu Ala
    1010                1015                1020                
Val Val Gly Val Pro Gln Pro Pro Ser Glu Gly Pro Ile Thr His Gln
1025                1030                1035                1040
Trp Ser Val Gln Met Glu Pro Pro Val Pro Cys His Tyr Glu Asp Leu
                1045                1050                1055    
Glu Arg Leu Pro Asp Ala Ala Glu Pro Cys Leu Pro Gly Ala Leu Phe
            1060                1065                1070        
Arg Cys Pro Val Val Phe Arg Gln Glu Ile Leu Val Gln Val Ile Gly
        1075                1080                1085            
Thr Leu Glu Leu Val Gly Glu Ile Glu Ala Ser Ser Met Phe Ser Leu
    1090                1095                1100                
Cys Ser Ser Leu Ser Ile Ser Phe Asn Ser Ser Lys His Phe His Leu
1105                1110                1115                1120
Tyr Gly Ser Asn Ala Ser Leu Ala Gln Val Val Met Lys Val Asp Val
                1125                1130                1135    
Val Tyr Glu Lys Gln Met Leu Tyr Leu Tyr Val Leu Ser Gly Ile Gly
            1140                1145                1150        
Gly Leu Leu Leu Leu Leu Leu Ile Phe Ile Val Leu Tyr Lys Val Gly
        1155                1160                1165            
Phe Phe Lys Arg Asn Leu Lys Glu Lys Met Glu Ala Gly Arg Gly Val
    1170                1175                1180                
Pro Asn Gly Ile Pro Ala Glu Asp Ser Glu Gln Leu Ala Ser Gly Gln
1185                1190                1195                1200
Glu Ala Gly Asp Pro Gly Cys Leu Lys Pro Leu His Glu Lys Asp Ser
                1205                1210                1215    
Glu Ser Gly Gly Gly Lys Asp
            1220            


<210> 296
<211> 285
<212> PRT
<213> Homo sapiens

<400> 296
Met Ala Ala Arg Val Leu Arg Ala Ala Glu Ala Leu Gly Arg Arg Leu
 1               5                  10                  15      
Leu Gln Arg Ala Ala Pro Cys Ser Leu Leu Pro Arg Leu Arg Thr Trp
            20                  25                  30          
Thr Ser Ser Ser Asn Arg Ser Arg Glu Asp Ser Trp Leu Lys Ser Leu
        35                  40                  45              
Phe Val Arg Lys Val Asp Pro Arg Lys Asp Ala His Ser Asn Leu Leu
    50                  55                  60                  
Ala Lys Lys Glu Thr Ser Asn Leu Tyr Lys Leu Gln Phe His Asn Val
65                  70                  75                  80  
Lys Pro Glu Cys Leu Glu Ala Tyr Asn Lys Ile Cys Gln Glu Val Leu
                85                  90                  95      
Pro Lys Ile His Glu Asp Lys His Tyr Pro Cys Thr Leu Val Gly Thr
            100                 105                 110         
Trp Asn Thr Trp Tyr Gly Glu Gln Asp Gln Ala Val His Leu Trp Arg
        115                 120                 125             
Tyr Glu Gly Gly Tyr Pro Ala Leu Thr Glu Val Met Asn Lys Leu Arg
    130                 135                 140                 
Glu Asn Lys Glu Phe Leu Glu Phe Arg Lys Ala Arg Ser Asp Met Leu
145                 150                 155                 160 
Leu Ser Arg Lys Asn Gln Leu Leu Leu Glu Phe Ser Phe Trp Asn Glu
                165                 170                 175     
Pro Val Pro Arg Ser Gly Pro Asn Ile Tyr Glu Leu Arg Ser Tyr Gln
            180                 185                 190         
Leu Arg Pro Gly Thr Met Ile Glu Trp Gly Asn Tyr Trp Ala Arg Ala
        195                 200                 205             
Ile Arg Phe Arg Gln Asp Gly Asn Glu Ala Val Gly Gly Phe Phe Ser
    210                 215                 220                 
Gln Ile Gly Gln Leu Tyr Met Val His His Leu Trp Ala Tyr Arg Asp
225                 230                 235                 240 
Leu Gln Thr Arg Glu Asp Ile Arg Asn Ala Ala Trp His Lys His Gly
                245                 250                 255     
Trp Glu Glu Leu Val Tyr Tyr Thr Val Pro Leu Ile Gln Glu Met Glu
            260                 265                 270         
Ser Arg Ile Met Ile Pro Leu Lys Thr Ser Pro Leu Gln
        275                 280                 285 


<210> 297
<211> 285
<212> PRT
<213> Homo sapiens

<400> 297
Met Ala Ala Arg Val Leu Arg Ala Ala Glu Ala Leu Gly Arg Arg Leu
 1               5                  10                  15      
Leu Gln Arg Ala Ala Pro Cys Ser Leu Leu Pro Arg Leu Arg Thr Trp
            20                  25                  30          
Thr Ser Ser Ser Asn Arg Ser Arg Glu Asp Ser Trp Leu Lys Ser Leu
        35                  40                  45              
Phe Val Arg Lys Val Asp Pro Arg Lys Asp Ala His Ser Asn Leu Leu
    50                  55                  60                  
Ala Lys Lys Glu Thr Ser Asn Leu Tyr Lys Leu Gln Phe His Asn Val
65                  70                  75                  80  
Lys Pro Glu Cys Leu Glu Ala Tyr Asn Lys Ile Cys Gln Glu Val Leu
                85                  90                  95      
Pro Lys Ile His Glu Asp Lys His Tyr Pro Cys Thr Leu Val Gly Thr
            100                 105                 110         
Trp Asn Thr Trp Tyr Gly Glu Gln Asp Gln Ala Val His Leu Trp Arg
        115                 120                 125             
Tyr Glu Gly Gly Tyr Pro Ala Leu Thr Glu Val Met Asn Lys Leu Arg
    130                 135                 140                 
Glu Asn Lys Glu Phe Leu Glu Phe Arg Lys Ala Arg Ser Asp Met Leu
145                 150                 155                 160 
Leu Ser Arg Lys Asn Gln Leu Leu Leu Glu Phe Ser Phe Trp Asn Glu
                165                 170                 175     
Pro Val Pro Arg Ser Gly Pro Asn Ile Tyr Glu Leu Arg Ser Tyr Gln
            180                 185                 190         
Leu Arg Pro Gly Thr Met Ile Glu Trp Gly Asn Tyr Trp Ala Arg Ala
        195                 200                 205             
Ile Arg Phe Arg Gln Asp Gly Asn Glu Ala Val Gly Gly Phe Phe Ser
    210                 215                 220                 
Gln Ile Gly Gln Leu Tyr Met Val His His Leu Trp Ala Tyr Arg Asp
225                 230                 235                 240 
Leu Gln Thr Arg Glu Asp Ile Arg Asn Ala Ala Trp His Lys His Gly
                245                 250                 255     
Trp Glu Glu Leu Val Tyr Tyr Thr Val Pro Leu Ile Gln Glu Met Glu
            260                 265                 270         
Ser Arg Ile Met Ile Pro Leu Lys Thr Ser Pro Leu Gln
        275                 280                 285 


<210> 298
<211> 1081
<212> PRT
<213> Homo sapiens

<400> 298
Met Gly Lys Leu Ile Arg Met Gly Pro Gln Glu Arg Trp Leu Leu Arg
 1               5                  10                  15      
Thr Lys Arg Leu His Trp Ser Arg Leu Leu Phe Leu Leu Gly Met Leu
            20                  25                  30          
Ile Ile Gly Ser Thr Tyr Gln His Leu Arg Arg Pro Arg Gly Leu Ser
        35                  40                  45              
Ser Leu Trp Ala Ala Val Ser Ser His Gln Pro Ile Lys Leu Ala Ser
    50                  55                  60                  
Arg Asp Leu Ser Ser Glu Glu Met Met Met Met Ser Ser Ser Pro Ser
65                  70                  75                  80  
Lys Pro Ser Ser Glu Met Gly Gly Lys Met Leu Val Pro Gln Ala Ser
                85                  90                  95      
Val Gly Ser Asp Glu Ala Thr Leu Ser Met Thr Val Glu Asn Ile Pro
            100                 105                 110         
Ser Met Pro Lys Arg Thr Ala Lys Met Ile Pro Thr Thr Thr Lys Asn
        115                 120                 125             
Asn Tyr Ser Pro Thr Ala Ala Gly Thr Glu Arg Arg Lys Glu Asp Thr
    130                 135                 140                 
Pro Thr Ser Ser Arg Thr Leu Thr Tyr Tyr Thr Ser Thr Ser Ser Arg
145                 150                 155                 160 
Gln Ile Val Lys Lys Tyr Thr Pro Thr Pro Arg Gly Glu Met Lys Ser
                165                 170                 175     
Tyr Ser Pro Thr Gln Val Arg Glu Lys Val Lys Tyr Thr Pro Ser Pro
            180                 185                 190         
Arg Gly Arg Arg Val Gly Thr Tyr Val Pro Ser Thr Phe Met Thr Met
        195                 200                 205             
Glu Thr Ser His Ala Ile Thr Pro Arg Thr Thr Val Lys Asp Ser Asp
    210                 215                 220                 
Ile Thr Ala Thr Tyr Lys Ile Leu Glu Thr Asn Ser Leu Lys Arg Ile
225                 230                 235                 240 
Met Glu Glu Thr Thr Pro Thr Thr Leu Lys Gly Met Phe Asp Ser Thr
                245                 250                 255     
Pro Thr Phe Leu Thr His Glu Val Glu Ala Asn Val Leu Thr Ser Pro
            260                 265                 270         
Arg Ser Val Met Glu Lys Asn Asn Leu Phe Pro Pro Arg Arg Val Glu
        275                 280                 285             
Ser Asn Ser Ser Ala His Pro Trp Gly Leu Val Gly Lys Ser Asn Pro
    290                 295                 300                 
Lys Thr Pro Gln Gly Thr Val Leu Leu His Thr Pro Ala Thr Ser Glu
305                 310                 315                 320 
Gly Gln Val Thr Ile Ser Thr Met Thr Gly Ser Ser Pro Ala Glu Thr
                325                 330                 335     
Lys Ala Phe Thr Ala Ala Trp Ser Leu Arg Asn Pro Ser Pro Arg Thr
            340                 345                 350         
Ser Val Ser Ala Ile Lys Thr Ala Pro Ala Ile Val Trp Arg Leu Ala
        355                 360                 365             
Lys Lys Pro Ser Thr Ala Pro Ser Thr Ser Thr Thr Pro Thr Val Arg
    370                 375                 380                 
Ala Lys Leu Thr Met Gln Val His His Cys Val Val Val Lys Pro Thr
385                 390                 395                 400 
Pro Ala Met Leu Thr Thr Pro Ser Pro Ser Leu Thr Thr Ala Leu Leu
                405                 410                 415     
Pro Glu Glu Leu Ser Pro Ser Pro Ser Val Leu Pro Pro Ser Leu Pro
            420                 425                 430         
Asp Leu His Pro Lys Gly Glu Tyr Pro Pro Asp Leu Phe Ser Val Glu
        435                 440                 445             
Glu Arg Arg Gln Gly Trp Val Val Leu His Val Phe Gly Met Met Tyr
    450                 455                 460                 
Val Phe Val Ala Leu Ala Ile Val Cys Asp Glu Tyr Phe Val Pro Ala
465                 470                 475                 480 
Leu Gly Val Ile Thr Asp Lys Leu Gln Ile Ser Glu Asp Val Ala Gly
                485                 490                 495     
Ala Thr Phe Met Ala Ala Gly Gly Ser Ala Pro Glu Leu Phe Thr Ser
            500                 505                 510         
Leu Ile Gly Ile Phe Ile Ser His Ser Asn Val Gly Ile Gly Thr Ile
        515                 520                 525             
Val Gly Ser Ala Val Phe Asn Ile Leu Phe Val Ile Gly Thr Cys Ser
    530                 535                 540                 
Leu Phe Ser Arg Glu Ile Leu Asn Leu Thr Trp Trp Pro Leu Phe Arg
545                 550                 555                 560 
Asp Val Ser Phe Tyr Ile Leu Asp Leu Ile Met Leu Ile Leu Phe Phe
                565                 570                 575     
Leu Asp Ser Leu Ile Ala Trp Trp Glu Ser Leu Leu Leu Leu Leu Ala
            580                 585                 590         
Tyr Ala Phe Tyr Val Phe Thr Met Lys Trp Asn Lys His Ile Glu Val
        595                 600                 605             
Trp Val Lys Glu Gln Leu Ser Arg Arg Pro Val Ala Lys Val Met Ala
    610                 615                 620                 
Leu Glu Asp Leu Ser Lys Leu Pro Ser Leu Leu Thr Arg Gly Ser Ser
625                 630                 635                 640 
Ser Thr Ser Leu His Asn Ser Thr Ile Arg Ser Thr Ile Tyr Gln Leu
                645                 650                 655     
Met Leu His Ser Leu Asp Pro Leu Arg Glu Val Arg Leu Ala Lys Glu
            660                 665                 670         
Lys Glu Glu Glu Ser Leu Asn Gln Gly Ala Arg Ala Gln Pro Gln Ala
        675                 680                 685             
Lys Ala Glu Ser Lys Pro Glu Glu Glu Glu Pro Ala Lys Leu Pro Ala
    690                 695                 700                 
Val Thr Val Thr Pro Ala Pro Val Pro Asp Ile Lys Gly Asp Gln Lys
705                 710                 715                 720 
Glu Asn Pro Gly Gly Gln Glu Asp Val Ala Glu Ala Glu Ser Thr Gly
                725                 730                 735     
Glu Met Pro Gly Glu Glu Gly Glu Thr Ala Gly Glu Gly Glu Thr Glu
            740                 745                 750         
Glu Lys Ser Gly Gly Glu Thr Gln Pro Glu Gly Glu Gly Glu Thr Glu
        755                 760                 765             
Thr Gln Gly Lys Gly Glu Glu Cys Glu Asp Glu Asn Glu Ala Glu Gly
    770                 775                 780                 
Lys Gly Asp Asn Glu Gly Glu Asp Glu Gly Glu Ile His Ala Glu Asp
785                 790                 795                 800 
Gly Glu Met Lys Gly Asn Glu Gly Glu Thr Glu Ser Gln Glu Leu Ser
                805                 810                 815     
Ala Glu Asn His Gly Glu Ala Lys Asn Asp Glu Lys Gly Val Glu Asp
            820                 825                 830         
Gly Gly Gly Ser Asp Gly Gly Asp Ser Glu Glu Glu Glu Glu Glu Glu
        835                 840                 845             
Glu Glu Gln Glu Glu Glu Glu Glu Glu Glu Glu Gln Glu Glu Glu Glu
    850                 855                 860                 
Glu Glu Glu Glu Glu Glu Glu Glu Lys Gly Asn Glu Glu Pro Leu Ser
865                 870                 875                 880 
Leu Asp Trp Pro Glu Thr Arg Gln Lys Gln Ala Ile Tyr Leu Phe Leu
                885                 890                 895     
Leu Pro Ile Val Phe Pro Leu Trp Leu Thr Val Pro Asp Val Arg Arg
            900                 905                 910         
Gln Glu Ser Arg Lys Phe Phe Val Phe Thr Phe Leu Gly Ser Ile Met
        915                 920                 925             
Trp Ile Ala Met Phe Ser Tyr Leu Met Val Trp Trp Ala His Gln Val
    930                 935                 940                 
Gly Glu Thr Ile Gly Ile Ser Glu Glu Ile Met Gly Leu Thr Ile Leu
945                 950                 955                 960 
Ala Ala Gly Thr Ser Ile Pro Asp Leu Ile Thr Ser Val Ile Val Ala
                965                 970                 975     
Arg Lys Gly Leu Gly Asp Met Ala Val Ser Ser Ser Val Gly Ser Asn
            980                 985                 990         
Ile Phe Asp Ile Thr Val Gly Leu Pro Val Pro Trp Leu Leu Phe Ser
        995                 1000                1005            
Leu Ile Asn Gly Leu Gln Pro Val Pro Val Ser Ser Asn Gly Leu Phe
    1010                1015                1020                
Cys Ala Ile Val Leu Leu Phe Leu Met Leu Leu Phe Val Ile Ser Ser
1025                1030                1035                1040
Ile Ala Ser Cys Lys Trp Arg Met Asn Lys Ile Leu Gly Phe Thr Met
                1045                1050                1055    
Phe Leu Leu Tyr Phe Val Phe Leu Ile Ile Ser Val Met Leu Glu Asp
            1060                1065                1070        
Arg Ile Ile Ser Cys Pro Val Ser Val
        1075                1080    


<210> 299
<211> 691
<212> PRT
<213> Homo sapiens

<400> 299
Met Cys Ser Ser Ile Leu Lys Asp Ile Leu His Leu Ala Glu His Asp
 1               5                  10                  15      
Gly Thr His Pro Glu Gln Gly Leu Tyr Thr Cys Ala Ala Glu His Asp
            20                  25                  30          
Leu His Gln Lys Glu Gln Ile Arg Glu Lys Leu Thr Arg Ser Asp Glu
        35                  40                  45              
Trp Arg Pro Ser Phe Val Asn His Ser Ala His Val Gly Glu Arg Asn
    50                  55                  60                  
Phe Thr Cys Thr Gln Gly Gly Lys Asp Phe Thr Ala Ser Ser Asp Leu
65                  70                  75                  80  
Leu Gln Gln Gln Val Leu Asn Ser Gly Trp Lys Leu Tyr Arg Asp Thr
                85                  90                  95      
Gln Asp Gly Glu Ala Phe Gln Gly Glu Gln Asn Asp Phe Asn Ser Ser
            100                 105                 110         
Gln Gly Gly Lys Asp Phe Cys His Gln His Gly Leu Phe Glu His Gln
        115                 120                 125             
Lys Thr His Asn Gly Glu Arg Pro Tyr Glu Phe Ser Glu Cys Gly Glu
    130                 135                 140                 
Leu Phe Arg Tyr Asn Ser Asn Leu Ile Lys Tyr Gln Gln Asn His Ala
145                 150                 155                 160 
Gly Glu Arg Pro Tyr Glu Gly Thr Glu Tyr Gly Lys Thr Phe Ile Arg
                165                 170                 175     
Lys Ser Asn Leu Val Gln His Gln Lys Ile His Ser Glu Gly Phe Leu
            180                 185                 190         
Ser Lys Arg Ser Asp Pro Ile Glu His Gln Glu Ile Leu Ser Arg Pro
        195                 200                 205             
Thr Pro Tyr Glu Cys Thr Gln Cys Gly Lys Ala Phe Leu Thr Gln Ala
    210                 215                 220                 
His Leu Val Gly His Gln Lys Thr His Thr Gly Glu Gln Pro Tyr Glu
225                 230                 235                 240 
Cys Asn Lys Cys Gly Lys Phe Phe Met Tyr Asn Ser Lys Leu Ile Arg
                245                 250                 255     
His Gln Lys Val His Thr Gly Glu Arg Arg Tyr Glu Cys Ser Glu Cys
            260                 265                 270         
Gly Lys Leu Phe Met Asp Ser Phe Thr Leu Gly Arg His Gln Arg Val
        275                 280                 285             
His Thr Gly Glu Arg Pro Phe Glu Cys Ser Ile Cys Gly Lys Phe Phe
    290                 295                 300                 
Ser His Arg Ser Thr Leu Asn Met His Gln Arg Val His Ala Gly Lys
305                 310                 315                 320 
Arg Leu Tyr Lys Cys Ser Glu Cys Gly Lys Ala Phe Ser Leu Lys His
                325                 330                 335     
Asn Val Val Gln His Leu Lys Ile His Thr Gly Glu Arg Pro Tyr Glu
            340                 345                 350         
Cys Thr Glu Cys Glu Lys Ala Phe Val Arg Lys Ser His Leu Val Gln
        355                 360                 365             
His Gln Lys Ile His Thr Asp Ala Phe Ser Lys Arg Ser Asp Leu Ile
    370                 375                 380                 
Gln His Lys Arg Ile Asp Ile Arg Pro Arg Pro Tyr Thr Cys Ser Glu
385                 390                 395                 400 
Cys Gly Lys Ala Phe Leu Thr Gln Ala His Leu Val Gly His Gln Lys
                405                 410                 415     
Ile His Thr Gly Glu Arg Pro Tyr Glu Cys Thr Gln Cys Ala Lys Ala
            420                 425                 430         
Phe Val Arg Lys Ser His Leu Val Gln His Glu Lys Ile His Thr Asp
        435                 440                 445             
Ala Phe Ser Lys Arg Ser Asp Leu Ile Gln His Lys Arg Ile Asp Leu
    450                 455                 460                 
Arg Pro Arg Pro Tyr Val Cys Ser Glu Cys Gly Lys Ala Phe Leu Thr
465                 470                 475                 480 
Gln Ala His Leu Asp Gly His Gln Lys Ile Gln Thr Gly Glu Arg Arg
                485                 490                 495     
Tyr Glu Cys Asn Glu Cys Gly Lys Phe Phe Leu Asp Ser Tyr Lys Leu
            500                 505                 510         
Val Ile His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Ser
        515                 520                 525             
Lys Cys Gly Lys Phe Phe Arg Tyr Arg Cys Thr Leu Ser Arg His Gln
    530                 535                 540                 
Lys Val His Thr Gly Glu Arg Pro Tyr Glu Cys Ser Glu Cys Gly Lys
545                 550                 555                 560 
Phe Phe Arg Asp Ser Tyr Lys Leu Ile Ile His Gln Arg Val His Thr
                565                 570                 575     
Gly Glu Lys Pro Tyr Glu Cys Ser Asn Cys Gly Lys Phe Leu Arg Tyr
            580                 585                 590         
Arg Ser Thr Phe Ile Lys His His Lys Val Cys Thr Gly Glu Lys Pro
        595                 600                 605             
His Glu Cys Ser Lys Cys Arg Glu Leu Phe Arg Thr Lys Ser Ser Leu
    610                 615                 620                 
Ile Ile His Gln Gln Ser His Thr Gly Glu Ser Pro Phe Lys Leu Arg
625                 630                 635                 640 
Glu Cys Gly Lys Asp Phe Asn Lys Cys Asn Thr Gly Gln Arg Gln Lys
                645                 650                 655     
Thr His Thr Gly Glu Arg Ser Tyr Glu Cys Gly Glu Ser Ser Lys Val
            660                 665                 670         
Phe Lys Tyr Asn Ser Ser Leu Ile Lys His Gln Ile Ile His Thr Gly
        675                 680                 685             
Lys Arg Pro
    690     


<210> 300
<211> 253
<212> PRT
<213> Homo sapiens

<400> 300
Glu Glu Asp Asp Asn Glu Glu Glu Gly Asp Arg Lys Thr Gly Lys Gln
 1               5                  10                  15      
Ala Phe Met Gly Glu Gln Glu Lys Leu Asp Val His Glu Lys Ser Lys
            20                  25                  30          
Ala Asp Lys Met Lys Glu Gly Ser Asp Ser Ser Val Ser Ser Glu Lys
        35                  40                  45              
Gly Gly Arg Leu Pro Thr Pro Lys Leu Arg Glu Leu Gly Gly Ile Gln
    50                  55                  60                  
Arg Thr His His Asp Leu Thr Thr Pro Ala Val Gly Gly Ala Val Leu
65                  70                  75                  80  
Val Ser Pro Ser Lys Met Lys Pro Pro Ala Pro Glu Gln Arg Lys Arg
                85                  90                  95      
Met Thr Ser Gln Asp Cys Leu Glu Thr Ser Lys Asn Asp Phe Thr Lys
            100                 105                 110         
Lys Glu Ser Arg Ala Val Ser Leu Leu Thr Ser Pro Ala Ala Gly Ile
        115                 120                 125             
Lys Thr Val Asp Pro Leu Pro Leu Arg Glu Asp Ser Glu Asp Asn Ile
    130                 135                 140                 
His Lys Phe Ala Glu Ala Thr Leu Pro Val Ser Lys Ile Pro Lys Tyr
145                 150                 155                 160 
Pro Thr Asn Pro Pro Gly Gln Leu Pro Ser Pro Pro His Val Pro Ser
                165                 170                 175     
Tyr Trp His Pro Ser Arg Arg Ile Gln Gly Ser Leu Arg Asp Pro Glu
            180                 185                 190         
Phe Gln His Asn Val Gly Lys Ala Arg Met Asn Asn Leu Gln Leu Pro
        195                 200                 205             
Gln His Glu Ala Phe Asn Asp Glu Asp Glu Asp Arg Leu Ser Glu Ile
    210                 215                 220                 
Ser Ala Arg Ser Ala Ala Ser Ser Leu Arg Ala Phe Gln Thr Leu Ala
225                 230                 235                 240 
Arg Ala Lys Lys Arg Lys Glu Asn Phe Trp Gly Lys Thr
                245                 250             


<210> 301
<211> 574
<212> PRT
<213> Homo sapiens

<400> 301
Lys Glu Ala Ala Ser Gly Lys Ser Asp Arg Arg Thr Pro Glu Ser Ser
 1               5                  10                  15      
Leu His Glu Ala Leu Asp Gln Cys Met Thr Ala Leu Asp Leu Phe Leu
            20                  25                  30          
Thr Asn Gln Phe Ser Glu Ala Leu Ser Tyr Leu Lys Pro Arg Thr Lys
        35                  40                  45              
Glu Ser Met Tyr His Ser Leu Thr Tyr Ala Thr Ile Leu Glu Met Gln
    50                  55                  60                  
Ala Met Met Thr Phe Asp Pro Gln Asp Ile Leu Leu Ala Gly Asn Met
65                  70                  75                  80  
Met Lys Glu Ala Gln Met Leu Cys Gln Arg His Arg Arg Lys Ser Ser
                85                  90                  95      
Val Thr Asp Ser Phe Ser Ser Leu Val Asn Arg Pro Thr Leu Gly Gln
            100                 105                 110         
Phe Thr Glu Glu Glu Ile His Ala Glu Val Cys Tyr Ala Glu Cys Leu
        115                 120                 125             
Leu Gln Arg Ala Ala Leu Thr Phe Leu Gln Asp Glu Asn Met Val Ser
    130                 135                 140                 
Phe Ile Lys Gly Gly Ile Lys Val Arg Asn Ser Tyr Gln Thr Tyr Lys
145                 150                 155                 160 
Glu Leu Asp Ser Leu Val Gln Ser Ser Gln Tyr Cys Lys Gly Glu Asn
                165                 170                 175     
His Pro His Phe Glu Gly Gly Val Lys Leu Gly Val Gly Ala Phe Asn
            180                 185                 190         
Leu Thr Leu Ser Met Leu Pro Thr Arg Ile Leu Arg Leu Leu Glu Phe
        195                 200                 205             
Val Gly Phe Ser Gly Asn Lys Asp Tyr Gly Leu Leu Gln Leu Glu Glu
    210                 215                 220                 
Gly Ala Ser Gly His Ser Phe Arg Ser Val Leu Cys Val Met Leu Leu
225                 230                 235                 240 
Leu Cys Tyr His Thr Phe Leu Thr Phe Val Leu Gly Thr Gly Asn Val
                245                 250                 255     
Asn Ile Glu Glu Ala Glu Lys Leu Leu Lys Pro Tyr Leu Asn Arg Tyr
            260                 265                 270         
Pro Lys Gly Ala Ile Phe Leu Phe Phe Ala Gly Arg Ile Glu Val Ile
        275                 280                 285             
Lys Gly Asn Ile Asp Ala Ala Ile Arg Arg Phe Glu Glu Cys Cys Glu
    290                 295                 300                 
Ala Gln Gln His Trp Lys Gln Phe His His Met Cys Tyr Trp Glu Leu
305                 310                 315                 320 
Met Trp Cys Phe Thr Tyr Lys Gly Gln Trp Lys Met Ser Tyr Phe Tyr
                325                 330                 335     
Ala Asp Leu Leu Ser Lys Glu Asn Cys Trp Ser Lys Ala Thr Tyr Ile
            340                 345                 350         
Tyr Met Lys Ala Ala Tyr Leu Ser Met Phe Gly Lys Glu Asp His Lys
        355                 360                 365             
Pro Phe Gly Asp Asp Glu Val Glu Leu Phe Arg Ala Val Pro Gly Leu
    370                 375                 380                 
Lys Leu Lys Ile Ala Gly Lys Ser Leu Pro Thr Glu Lys Phe Ala Ile
385                 390                 395                 400 
Arg Lys Ser Arg Arg Tyr Phe Ser Ser Asn Pro Ile Ser Leu Pro Val
                405                 410                 415     
Pro Ala Leu Glu Met Met Tyr Ile Trp Asn Gly Tyr Ala Val Ile Gly
            420                 425                 430         
Lys Gln Pro Lys Leu Thr Asp Gly Ile Leu Glu Ile Ile Thr Lys Ala
        435                 440                 445             
Glu Glu Met Leu Glu Lys Gly Pro Glu Asn Glu Tyr Ser Val Asp Asp
    450                 455                 460                 
Glu Cys Leu Val Lys Leu Leu Lys Gly Leu Cys Leu Lys Tyr Leu Gly
465                 470                 475                 480 
Arg Val Gln Glu Ala Glu Glu Asn Phe Arg Ser Ile Ser Ala Asn Glu
                485                 490                 495     
Lys Lys Ile Lys Tyr Asp His Tyr Leu Ile Pro Asn Ala Leu Leu Glu
            500                 505                 510         
Leu Ala Leu Leu Leu Met Glu Gln Asp Arg Asn Glu Glu Ala Ile Lys
        515                 520                 525             
Leu Leu Glu Ser Ala Lys Gln Asn Tyr Lys Asn Tyr Ser Met Glu Ser
    530                 535                 540                 
Arg Thr His Phe Arg Ile Gln Ala Ala Thr Leu Gln Ala Lys Ser Ser
545                 550                 555                 560 
Leu Glu Asn Ser Ser Arg Ser Met Val Ser Ser Val Ser Leu
                565                 570                 


<210> 302
<211> 962
<212> PRT
<213> Homo sapiens

<400> 302
Met Asp Glu Gln Ala Leu Leu Gly Leu Asn Pro Asn Ala Asp Ser Asp
 1               5                  10                  15      
Phe Arg Gln Arg Ala Leu Ala Tyr Phe Glu Gln Leu Lys Ile Ser Pro
            20                  25                  30          
Asp Ala Trp Gln Val Cys Ala Glu Ala Leu Ala Gln Arg Thr Tyr Ser
        35                  40                  45              
Asp Asp His Val Lys Phe Phe Cys Phe Gln Val Leu Glu His Gln Val
    50                  55                  60                  
Lys Tyr Lys Tyr Ser Glu Leu Thr Thr Val Gln Gln Gln Leu Ile Arg
65                  70                  75                  80  
Glu Thr Leu Ile Ser Trp Leu Gln Ala Gln Met Leu Asn Pro Gln Pro
                85                  90                  95      
Glu Lys Thr Phe Ile Arg Asn Lys Ala Ala Gln Val Phe Ala Leu Leu
            100                 105                 110         
Phe Val Thr Glu Tyr Leu Thr Lys Trp Pro Lys Phe Phe Phe Asp Ile
        115                 120                 125             
Leu Ser Val Val Asp Leu Asn Pro Arg Gly Val Asp Leu Tyr Leu Arg
    130                 135                 140                 
Ile Leu Met Ala Ile Asp Ser Glu Leu Val Asp Arg Asp Val Val His
145                 150                 155                 160 
Thr Ser Glu Glu Ala Arg Arg Asn Thr Leu Ile Lys Asp Thr Met Arg
                165                 170                 175     
Glu Gln Cys Ile Pro Asn Leu Val Glu Ser Trp Tyr Gln Ile Leu Gln
            180                 185                 190         
Asn Tyr Gln Phe Thr Asn Ser Glu Val Thr Cys Gln Cys Leu Glu Val
        195                 200                 205             
Val Gly Ala Tyr Val Ser Trp Ile Asp Leu Ser Leu Ile Ala Asn Asp
    210                 215                 220                 
Arg Phe Ile Asn Met Leu Leu Gly His Met Ser Ile Glu Val Leu Arg
225                 230                 235                 240 
Glu Glu Ala Cys Asp Cys Leu Phe Glu Val Val Asn Lys Gly Met Asp
                245                 250                 255     
Pro Val Asp Lys Met Lys Leu Val Glu Ser Leu Cys Gln Val Leu Gln
            260                 265                 270         
Ser Ala Gly Phe Phe Ser Ile Asp Gln Glu Glu Asp Val Asp Phe Leu
        275                 280                 285             
Ala Arg Phe Ser Lys Leu Val Asn Gly Met Gly Gln Ser Leu Ile Val
    290                 295                 300                 
Ser Trp Ser Lys Leu Ile Lys Asn Gly Asp Ile Lys Asn Ala Gln Glu
305                 310                 315                 320 
Ala Leu Gln Ala Ile Glu Thr Lys Val Ala Leu Met Leu Gln Leu Leu
                325                 330                 335     
Ile His Glu Asp Asp Asp Ile Ser Ser Asn Ile Ile Gly Phe Cys Tyr
            340                 345                 350         
Asp Tyr Leu His Ile Leu Lys Arg Leu Thr Val Leu Ser Asp Gln Gln
        355                 360                 365             
Lys Ala Asn Val Glu Ala Ile Met Leu Ala Val Met Lys Lys Leu Thr
    370                 375                 380                 
Tyr Asp Glu Glu Tyr Asn Phe Glu Asn Glu Gly Glu Asp Glu Ala Met
385                 390                 395                 400 
Phe Val Glu Tyr Arg Lys Gln Leu Lys Leu Leu Leu Asp Arg Leu Ala
                405                 410                 415     
Gln Val Ser Pro Glu Leu Leu Leu Ala Ser Val Arg Arg Val Phe Ser
            420                 425                 430         
Ser Thr Leu Gln Asn Trp Gln Thr Thr Arg Phe Met Glu Val Glu Val
        435                 440                 445             
Ala Ile Arg Leu Leu Tyr Met Leu Ala Glu Ala Leu Pro Val Ser His
    450                 455                 460                 
Gly Ala His Phe Ser Gly Asp Val Ser Lys Ala Ser Ala Leu Gln Asp
465                 470                 475                 480 
Met Met Arg Thr Leu Val Thr Ser Gly Val Ser Ser Tyr Gln His Thr
                485                 490                 495     
Ser Val Thr Leu Glu Phe Phe Glu Thr Val Val Arg Tyr Glu Lys Phe
            500                 505                 510         
Phe Thr Val Glu Pro Gln His Ile Pro Cys Val Leu Met Ala Phe Leu
        515                 520                 525             
Asp His Arg Gly Leu Arg His Ser Ser Ala Lys Val Arg Ser Arg Thr
    530                 535                 540                 
Ala Tyr Leu Phe Ser Arg Phe Val Lys Ser Leu Asn Lys Gln Met Asn
545                 550                 555                 560 
Pro Phe Ile Glu Asp Ile Leu Asn Arg Ile Gln Asp Leu Leu Glu Leu
                565                 570                 575     
Ser Pro Pro Glu Asn Gly His Gln Ser Leu Leu Ser Ser Asp Asp Gln
            580                 585                 590         
Leu Phe Ile Tyr Glu Thr Ala Gly Val Leu Ile Val Asn Ser Glu Tyr
        595                 600                 605             
Pro Ala Glu Arg Lys Gln Ala Leu Met Arg Asn Leu Leu Thr Pro Leu
    610                 615                 620                 
Met Glu Lys Phe Lys Ile Leu Leu Glu Lys Leu Met Leu Ala Gln Asp
625                 630                 635                 640 
Glu Glu Arg Gln Ala Ser Leu Ala Asp Cys Leu Asn His Ala Val Gly
                645                 650                 655     
Phe Ala Ser Arg Thr Ser Lys Ala Phe Ser Asn Lys Gln Thr Val Lys
            660                 665                 670         
Gln Cys Gly Cys Ser Glu Val Tyr Leu Asp Cys Leu Gln Thr Phe Leu
        675                 680                 685             
Pro Ala Leu Ser Cys Pro Leu Gln Lys Asp Ile Leu Arg Ser Gly Val
    690                 695                 700                 
Arg Thr Phe Leu His Arg Met Ile Ile Cys Leu Glu Glu Glu Val Leu
705                 710                 715                 720 
Pro Phe Ile Pro Ser Ala Ser Glu His Met Leu Lys Asp Cys Glu Ala
                725                 730                 735     
Lys Asp Leu Gln Glu Phe Ile Pro Leu Ile Asn Gln Ile Thr Ala Lys
            740                 745                 750         
Phe Lys Ile Gln Val Ser Pro Phe Leu Gln Gln Met Phe Met Pro Leu
        755                 760                 765             
Leu His Ala Ile Phe Glu Val Leu Leu Arg Pro Ala Glu Glu Asn Asp
    770                 775                 780                 
Gln Ser Ala Ala Leu Glu Lys Gln Met Leu Arg Arg Ser Tyr Phe Ala
785                 790                 795                 800 
Phe Leu Gln Thr Val Thr Gly Ser Gly Met Ser Glu Val Ile Ala Asn
                805                 810                 815     
Gln Gly Ala Glu Asn Val Glu Arg Val Leu Val Thr Val Ile Gln Gly
            820                 825                 830         
Ala Val Glu Tyr Pro Asp Pro Ile Ala Gln Lys Thr Cys Phe Ile Ile
        835                 840                 845             
Leu Ser Lys Leu Val Glu Leu Trp Gly Gly Lys Asp Gly Pro Val Gly
    850                 855                 860                 
Phe Ala Asp Phe Val Tyr Lys His Ile Val Pro Ala Cys Phe Leu Ala
865                 870                 875                 880 
Pro Leu Lys Gln Thr Phe Asp Leu Ala Asp Ala Gln Thr Val Leu Ala
                885                 890                 895     
Leu Ser Glu Cys Ala Val Thr Leu Lys Thr Ile His Leu Lys Arg Gly
            900                 905                 910         
Pro Glu Cys Val Gln Tyr Leu Gln Gln Glu Tyr Leu Pro Ser Leu Gln
        915                 920                 925             
Val Ala Pro Glu Ile Ile Gln Glu Phe Cys Gln Ala Leu Gln Gln Pro
    930                 935                 940                 
Asp Ala Lys Val Phe Lys Asn Tyr Leu Lys Val Phe Phe Gln Arg Ala
945                 950                 955                 960 
Lys Pro
        


<210> 303
<211> 164
<212> PRT
<213> Homo sapiens

<400> 303
Val Asn Pro Thr Val Phe Phe Asp Ile Ala Val Asp Gly Glu Pro Leu
 1               5                  10                  15      
Gly Arg Val Ser Phe Glu Leu Phe Ala Asp Lys Val Pro Lys Thr Ala
            20                  25                  30          
Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu Lys Gly Phe Gly Tyr Lys
        35                  40                  45              
Gly Ser Cys Phe His Arg Ile Ile Pro Gly Phe Met Cys Gln Gly Gly
    50                  55                  60                  
Asp Phe Thr Arg His Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly Glu
65                  70                  75                  80  
Lys Phe Glu Asp Glu Asn Phe Ile Leu Lys His Thr Gly Pro Gly Ile
                85                  90                  95      
Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe Phe
            100                 105                 110         
Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp Gly Lys His Val Val Phe
        115                 120                 125             
Gly Lys Val Lys Glu Gly Met Asn Ile Val Glu Ala Met Glu Arg Phe
    130                 135                 140                 
Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys Ile Thr Ile Ala Asp Cys
145                 150                 155                 160 
Gly Gln Leu Glu
                


<210> 304
<211> 458
<212> PRT
<213> Homo sapiens

<400> 304
Ile Thr Pro Thr Glu Glu Gly Leu Lys Asn Ser Thr Gln Met Ser Ala
 1               5                  10                  15      
Thr Tyr Ser Gln Gly Phe Thr Ile Trp Leu Gly Pro Ile Ile Pro Phe
            20                  25                  30          
Ile Val Leu Cys His Pro Asp Thr Ile Arg Ser Ile Thr Asn Ala Ser
        35                  40                  45              
Ala Ala Ile Ala Pro Lys Asp Asn Leu Phe Ile Arg Phe Leu Lys Pro
    50                  55                  60                  
Trp Leu Gly Glu Gly Ile Leu Leu Ser Gly Gly Asp Lys Trp Ser Arg
65                  70                  75                  80  
His Arg Arg Met Leu Thr Pro Ala Phe His Phe Asn Ile Leu Lys Ser
                85                  90                  95      
Tyr Ile Thr Ile Phe Asn Lys Ser Ala Asn Ile Met Leu Asp Lys Trp
            100                 105                 110         
Gln His Leu Ala Ser Glu Gly Ser Ser Cys Leu Asp Met Phe Glu His
        115                 120                 125             
Ile Ser Leu Met Thr Leu Asp Ser Leu Gln Lys Cys Ile Phe Ser Phe
    130                 135                 140                 
Asp Ser His Cys Gln Glu Arg Pro Ser Glu Tyr Ile Ala Thr Ile Leu
145                 150                 155                 160 
Glu Leu Ser Ala Leu Val Glu Lys Arg Ser Gln His Ile Leu Gln His
                165                 170                 175     
Met Asp Phe Leu Tyr Tyr Leu Ser His Asp Gly Arg Arg Phe His Arg
            180                 185                 190         
Ala Cys Arg Leu Val His Asp Phe Thr Asp Ala Val Ile Arg Glu Arg
        195                 200                 205             
Arg Arg Thr Leu Pro Thr Gln Gly Ile Asp Asp Phe Phe Lys Asp Lys
    210                 215                 220                 
Ala Lys Ser Lys Thr Leu Asp Phe Ile Asp Val Leu Leu Leu Ser Lys
225                 230                 235                 240 
Asp Glu Asp Gly Lys Ala Leu Ser Asp Glu Asp Ile Arg Ala Glu Ala
                245                 250                 255     
Asp Thr Phe Met Phe Gly Gly His Asp Thr Thr Ala Ser Gly Leu Ser
            260                 265                 270         
Trp Val Leu Tyr Asn Leu Ala Arg His Pro Glu Tyr Gln Glu Arg Cys
        275                 280                 285             
Arg Gln Glu Val Gln Glu Leu Leu Lys Asp Arg Asp Pro Lys Glu Ile
    290                 295                 300                 
Glu Trp Asp Asp Leu Ala Gln Leu Pro Phe Leu Thr Met Cys Val Lys
305                 310                 315                 320 
Glu Ser Leu Arg Leu His Pro Pro Ala Pro Phe Ile Ser Arg Cys Cys
                325                 330                 335     
Thr Gln Asp Ile Val Leu Pro Asp Gly Arg Val Ile Pro Lys Gly Ile
            340                 345                 350         
Thr Cys Leu Ile Asp Ile Ile Gly Val His His Asn Pro Thr Val Trp
        355                 360                 365             
Pro Asp Pro Glu Val Tyr Asp Pro Phe Arg Phe Asp Pro Glu Asn Ser
    370                 375                 380                 
Lys Gly Arg Ser Pro Leu Ala Phe Ile Pro Phe Ser Ala Gly Pro Arg
385                 390                 395                 400 
Asn Cys Ile Gly Gln Ala Phe Ala Met Ala Glu Met Lys Val Val Leu
                405                 410                 415     
Ala Leu Met Leu Leu His Phe Arg Phe Leu Pro Asp His Thr Glu Pro
            420                 425                 430         
Arg Arg Lys Leu Glu Leu Ile Met Arg Ala Glu Gly Gly Leu Trp Leu
        435                 440                 445             
Arg Val Glu Pro Leu Asn Val Ser Leu Gln
    450                 455             


<210> 305
<211> 50
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 30
<223> Xaa = Any Amino Acid

<400> 305
Met Ser Lys Arg Phe Arg Gln Ser Ser His Leu Thr Thr His Lys Ile
 1               5                  10                  15      
Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Xaa Lys Leu
            20                  25                  30          
Ser Thr Asp Ser Phe Thr Leu Leu His Ile Arg Glu Phe Thr Leu Glu
        35                  40                  45              
Arg Asn
    50  


<210> 306
<211> 116
<212> PRT
<213> Homo sapiens

<400> 306
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ile Gly
 1               5                  10                  15      
Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Phe
            20                  25                  30          
Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Ser Ser Asn Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Pro
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe
        115     


<210> 307
<211> 1563
<212> PRT
<213> Homo sapiens

<400> 307
Val Asn Ser Ser Asn Pro Phe Phe Thr Ser Gln Thr Lys Ala Asn Gly
 1               5                  10                  15      
Asn Pro Ala Cys Ser Ala Gln Leu Gln His Val Ser Pro Pro Ile Phe
            20                  25                  30          
Pro Ala His Leu Ala Ser Val Ser Thr Pro Leu Leu Ser Ser Met Glu
        35                  40                  45              
Ser Val Ile Asn Pro Asn Ile Thr Ser Gln Asp Lys Asn Glu Gln Gly
    50                  55                  60                  
Gly Met Leu Cys Ser Gln Met Glu Asn Leu Pro Ser Thr Ala Leu Pro
65                  70                  75                  80  
Ala Gln Met Glu Asp Leu Thr Lys Thr Val Leu Pro Leu Asn Ile Asp
                85                  90                  95      
Ser Gly Ser Asp Pro Phe Leu Pro Leu Pro Ala Glu Ser Ser Ser Met
            100                 105                 110         
Ser Leu Phe Pro Ser Pro Ala Asp Ser Gly Thr Asn Ser Val Phe Ser
        115                 120                 125             
Gln Leu Glu Asn Asn Thr Asn His Tyr Ser Ser Gln Ile Glu Gly Asn
    130                 135                 140                 
Thr Asn Ser Ser Phe Leu Lys Gly Gly Asn Gly Glu Asn Ala Val Phe
145                 150                 155                 160 
Pro Ser Gln Val Asn Val Ala Asn Asn Phe Ser Ser Thr Asn Ala Gln
                165                 170                 175     
Gln Ser Ala Pro Glu Lys Val Lys Lys Asp Arg Gly Arg Gly Pro Asn
            180                 185                 190         
Gly Lys Glu Arg Lys Pro Lys His Asn Lys Arg Ala Lys Trp Pro Ala
        195                 200                 205             
Ile Ile Arg Asp Gly Lys Phe Ile Cys Ser Arg Cys Tyr Arg Ala Phe
    210                 215                 220                 
Thr Asn Pro Arg Ser Leu Gly Gly His Leu Ser Lys Arg Ser Tyr Cys
225                 230                 235                 240 
Lys Pro Leu Asp Gly Ala Glu Ile Ala Gln Glu Leu Leu Gln Ser Asn
                245                 250                 255     
Gly Gln Pro Ser Leu Leu Ala Ser Met Ile Leu Ser Thr Asn Ala Val
            260                 265                 270         
Asn Leu Gln Gln Pro Gln Gln Ser Thr Phe Asn Pro Glu Ala Cys Phe
        275                 280                 285             
Lys Asp Pro Ser Phe Leu Gln Leu Leu Ala Glu Asn Arg Ser Pro Ala
    290                 295                 300                 
Phe Leu Pro Asn Thr Phe Pro Arg Ser Gly Val Thr Asn Phe Asn Thr
305                 310                 315                 320 
Ser Val Ser Gln Glu Gly Ser Glu Ile Ile Lys Gln Ala Leu Glu Thr
                325                 330                 335     
Ala Gly Ile Pro Ser Thr Phe Glu Gly Ala Glu Met Leu Ser His Val
            340                 345                 350         
Ser Thr Gly Cys Val Ser Asp Ala Ser Gln Val Asn Ala Thr Val Met
        355                 360                 365             
Pro Asn Pro Thr Val Pro Pro Leu Leu His Thr Val Cys His Pro Asn
    370                 375                 380                 
Thr Leu Leu Thr Asn Gln Asn Arg Thr Ser Asn Ser Lys Thr Ser Ser
385                 390                 395                 400 
Ile Glu Glu Cys Ser Ser Leu Pro Val Phe Pro Thr Asn Asp Leu Leu
                405                 410                 415     
Leu Lys Thr Val Glu Asn Gly Leu Cys Ser Ser Ser Phe Pro Asn Ser
            420                 425                 430         
Gly Gly Pro Ser Gln Asn Phe Thr Ser Asn Ser Ser Arg Val Ser Val
        435                 440                 445             
Ile Ser Gly Pro Gln Asn Thr Arg Ser Ser His Leu Asn Lys Lys Gly
    450                 455                 460                 
Asn Ser Ala Ser Lys Arg Arg Lys Lys Val Ala Pro Pro Leu Ile Ala
465                 470                 475                 480 
Pro Asn Ala Ser Gln Asn Leu Val Thr Ser Asp Leu Thr Thr Met Gly
                485                 490                 495     
Leu Ile Ala Lys Ser Val Glu Ile Pro Thr Thr Asn Leu His Ser Asn
            500                 505                 510         
Val Ile Pro Thr Cys Glu Pro Gln Ser Leu Val Glu Asn Leu Thr Gln
        515                 520                 525             
Lys Leu Asn Asn Val Asn Asn Gln Leu Phe Met Thr Asp Val Lys Glu
    530                 535                 540                 
Asn Phe Lys Thr Ser Leu Glu Ser His Thr Val Leu Ala Pro Leu Thr
545                 550                 555                 560 
Leu Lys Thr Glu Asn Gly Asp Ser Gln Met Met Ala Leu Asn Ser Cys
                565                 570                 575     
Thr Thr Ser Val Asn Ser Asp Leu Gln Ile Ser Glu Asp Asn Val Ile
            580                 585                 590         
Gln Asn Phe Glu Lys Thr Leu Glu Ile Ile Lys Thr Ala Met Asn Ser
        595                 600                 605             
Gln Ile Leu Glu Val Lys Ser Gly Ser Gln Gly Ala Gly Glu Thr Ser
    610                 615                 620                 
Gln Asn Ala Gln Ile Asn Tyr Asn Ile Gln Leu Pro Ser Val Asn Thr
625                 630                 635                 640 
Val Gln Asn Asn Lys Leu Pro Asp Ser Ser Pro Phe Ser Ser Phe Ile
                645                 650                 655     
Ser Val Met Pro Thr Lys Ser Asn Ile Pro Gln Ser Glu Val Ser His
            660                 665                 670         
Lys Glu Asp Gln Ile Gln Glu Ile Leu Glu Gly Leu Gln Lys Leu Lys
        675                 680                 685             
Leu Glu Asn Asp Leu Ser Thr Pro Ala Ser Gln Cys Val Leu Ile Asn
    690                 695                 700                 
Thr Ser Val Thr Leu Thr Pro Thr Pro Val Lys Ser Thr Ala Asp Ile
705                 710                 715                 720 
Thr Val Ile Gln Pro Val Ser Glu Met Ile Asn Ile Gln Phe Asn Asp
                725                 730                 735     
Lys Val Asn Lys Pro Phe Val Cys Gln Asn Gln Gly Cys Asn Tyr Ser
            740                 745                 750         
Ala Met Thr Lys Asp Ala Leu Phe Lys His Tyr Gly Lys Ile His Gln
        755                 760                 765             
Tyr Thr Pro Glu Met Ile Leu Glu Ile Lys Lys Asn Gln Leu Lys Phe
    770                 775                 780                 
Ala Pro Phe Lys Cys Val Val Pro Thr Cys Thr Lys Thr Phe Thr Arg
785                 790                 795                 800 
Asn Ser Asn Leu Arg Ala His Cys Gln Leu Val His His Phe Thr Thr
                805                 810                 815     
Glu Glu Met Val Lys Leu Lys Ile Lys Arg Pro Tyr Gly Arg Lys Ser
            820                 825                 830         
Gln Ser Glu Asn Val Pro Ala Ser Arg Ser Thr Gln Val Lys Lys Gln
        835                 840                 845             
Leu Ala Met Thr Glu Glu Asn Lys Lys Glu Ser Gln Pro Ala Leu Glu
    850                 855                 860                 
Leu Arg Ala Glu Thr Gln Asn Thr His Ser Asn Val Ala Val Ile Pro
865                 870                 875                 880 
Glu Lys Gln Leu Ile Glu Lys Lys Ser Pro Asp Lys Thr Glu Ser Ser
                885                 890                 895     
Leu Gln Val Ile Thr Val Thr Ser Glu Gln Cys Asn Thr Asn Ala Leu
            900                 905                 910         
Thr Asn Thr Gln Thr Lys Gly Arg Lys Ile Arg Arg His Lys Lys Glu
        915                 920                 925             
Lys Glu Glu Lys Lys Arg Lys Lys Pro Val Ser Gln Ser Leu Glu Phe
    930                 935                 940                 
Pro Thr Arg Tyr Ser Pro Tyr Arg Pro Tyr Arg Cys Val His Gln Gly
945                 950                 955                 960 
Cys Phe Ala Ala Phe Thr Ile Gln Gln Asn Leu Ile Leu His Tyr Gln
                965                 970                 975     
Ala Val His Lys Ser Asp Leu Pro Ala Phe Ser Ala Glu Val Glu Glu
            980                 985                 990         
Glu Ser Glu Ala Gly Lys Glu Ser Glu Glu Thr Glu Thr Lys Gln Thr
        995                 1000                1005            
Leu Lys Glu Phe Arg Cys Gln Val Ser Asp Cys Ser Arg Ile Phe Gln
    1010                1015                1020                
Ala Ile Thr Gly Leu Ile Gln His Tyr Met Lys Leu His Glu Met Thr
1025                1030                1035                1040
Pro Glu Glu Ile Glu Ser Met Thr Ala Ser Val Asp Val Gly Lys Phe
                1045                1050                1055    
Pro Cys Asp Gln Leu Glu Cys Lys Ser Ser Phe Thr Thr Tyr Leu Asn
            1060                1065                1070        
Tyr Val Val His Leu Glu Ala Asp His Gly Ile Gly Leu Arg Ala Ser
        1075                1080                1085            
Lys Thr Glu Glu Asp Gly Val Tyr Lys Cys Asp Cys Glu Gly Cys Asp
    1090                1095                1100                
Arg Ile Tyr Ala Thr Arg Ser Asn Leu Leu Arg His Ile Phe Asn Lys
1105                1110                1115                1120
His Asn Asp Lys His Lys Ala His Leu Ile Arg Pro Arg Arg Leu Thr
                1125                1130                1135    
Pro Gly Gln Glu Asn Met Ser Ser Lys Ala Asn Gln Glu Lys Ser Lys
            1140                1145                1150        
Ser Lys His Arg Gly Thr Lys His Ser Arg Cys Gly Lys Glu Gly Ile
        1155                1160                1165            
Lys Met Pro Lys Thr Lys Arg Lys Lys Lys Asn Asn Leu Glu Asn Lys
    1170                1175                1180                
Asn Ala Lys Ile Val Gln Ile Glu Glu Asn Lys Pro Tyr Ser Leu Lys
1185                1190                1195                1200
Arg Gly Lys His Val Tyr Ser Ile Lys Ala Arg Asn Asp Ala Leu Ser
                1205                1210                1215    
Glu Cys Thr Ser Arg Phe Val Thr Gln Tyr Pro Cys Met Ile Lys Gly
            1220                1225                1230        
Cys Thr Ser Val Val Thr Ser Glu Ser Asn Ile Ile Arg His Tyr Lys
        1235                1240                1245            
Cys His Lys Leu Ser Lys Ala Phe Thr Ser Gln His Arg Asn Leu Leu
    1250                1255                1260                
Ile Val Phe Lys Arg Cys Cys Asn Ser Gln Val Lys Glu Thr Ser Glu
1265                1270                1275                1280
Gln Glu Gly Ala Lys Asn Asp Val Lys Asp Ser Asp Thr Cys Val Ser
                1285                1290                1295    
Glu Ser Asn Asp Asn Ser Arg Thr Thr Ala Thr Val Ser Gln Lys Glu
            1300                1305                1310        
Val Glu Lys Asn Glu Lys Asp Glu Met Asp Glu Leu Thr Glu Leu Phe
        1315                1320                1325            
Ile Thr Lys Leu Ile Asn Glu Asp Ser Thr Ser Val Glu Thr Gln Ala
    1330                1335                1340                
Asn Thr Ser Ser Asn Val Ser Asn Asp Phe Gln Glu Asp Asn Leu Cys
1345                1350                1355                1360
Gln Ser Glu Arg Gln Lys Ala Ser Asn Leu Lys Arg Val Asn Lys Glu
                1365                1370                1375    
Lys Asn Val Ser Gln Asn Lys Lys Arg Lys Val Glu Lys Ala Glu Pro
            1380                1385                1390        
Ala Ser Ala Ala Glu Leu Ser Ser Val Arg Lys Glu Glu Glu Thr Ala
        1395                1400                1405            
Val Ala Ile Gln Thr Ile Glu Glu His Pro Ala Ser Phe Asp Trp Ser
    1410                1415                1420                
Ser Phe Lys Pro Met Gly Phe Glu Val Ser Phe Leu Lys Phe Leu Glu
1425                1430                1435                1440
Glu Ser Ala Val Lys Gln Lys Lys Asn Thr Asp Lys Asp His Pro Asn
                1445                1450                1455    
Thr Gly Asn Lys Lys Gly Ser His Ser Asn Ser Arg Lys Asn Ile Asp
            1460                1465                1470        
Lys Thr Ala Val Thr Ser Gly Asn His Val Cys Pro Cys Lys Glu Ser
        1475                1480                1485            
Glu Thr Phe Val Gln Phe Ala Asn Pro Ser Gln Leu Gln Cys Ser Asp
    1490                1495                1500                
Asn Val Lys Ile Val Leu Asp Lys Asn Leu Lys Asp Cys Thr Glu Leu
1505                1510                1515                1520
Val Leu Lys Gln Leu Gln Glu Met Lys Pro Thr Val Ser Leu Lys Lys
                1525                1530                1535    
Leu Glu Val His Ser Asn Asp Pro Asp Met Ser Val Met Lys Asp Ile
            1540                1545                1550        
Ser Ile Gly Lys Ala Thr Gly Arg Gly Gln Tyr
        1555                1560            


<210> 308
<211> 1308
<212> PRT
<213> Homo sapiens

<400> 308
Asp Glu Ser Ser Leu Leu Arg Arg Arg Gly Leu Gln Lys Glu Leu Ser
 1               5                  10                  15      
Leu Pro Arg Arg Gly Arg Gly Cys Arg Ser Gly Asn Arg Lys Ser Leu
            20                  25                  30          
Val Val Gly Thr Pro Ser Pro Thr Leu Ser Arg Pro Leu Ser Pro Leu
        35                  40                  45              
Ser Val Pro Thr Ala Gly Ser Ser Pro Leu Asp Ser Pro Arg Asn Phe
    50                  55                  60                  
Ser Ala Ala Ser Ala Leu Asn Phe Pro Phe Ala Arg Arg Ala Asp Gly
65                  70                  75                  80  
Arg Arg Trp Ser Leu Ala Ser Leu Pro Ser Ser Gly Tyr Gly Thr Asn
                85                  90                  95      
Thr Pro Ser Ser Thr Leu Ser Ser Ser Ser Ser Ser Arg Glu Arg Leu
            100                 105                 110         
His Gln Leu Pro Phe Gln Pro Thr Pro Asp Glu Leu His Phe Leu Ser
        115                 120                 125             
Lys His Phe Arg Ser Ser Glu Asn Val Leu Asp Glu Glu Gly Gly Arg
    130                 135                 140                 
Ser Pro Arg Leu Arg Pro Arg Ser Arg Ser Leu Ser Pro Gly Arg Ala
145                 150                 155                 160 
Thr Gly Thr Phe Asp Asn Glu Ile Val Met Met Asn His Val Tyr Arg
                165                 170                 175     
Glu Arg Phe Pro Lys Ala Thr Ala Gln Met Glu Gly Arg Leu Gln Glu
            180                 185                 190         
Phe Leu Thr Ala Tyr Ala Pro Gly Ala Arg Leu Ala Leu Ala Asp Gly
        195                 200                 205             
Val Leu Gly Phe Ile His His Gln Ile Val Glu Leu Ala Arg Asp Cys
    210                 215                 220                 
Leu Ala Lys Ser Gly Glu Asn Leu Val Thr Ser Arg Tyr Phe Leu Glu
225                 230                 235                 240 
Met Gln Glu Lys Leu Glu Arg Leu Leu Gln Asp Ala His Glu Arg Ser
                245                 250                 255     
Asp Ser Glu Glu Val Ser Phe Ile Val Gln Leu Val Arg Lys Leu Leu
            260                 265                 270         
Ile Ile Ile Ser Arg Pro Ala Arg Leu Leu Glu Cys Leu Glu Phe Asp
        275                 280                 285             
Pro Glu Glu Phe Tyr His Leu Leu Glu Ala Ala Glu Gly His Ala Arg
    290                 295                 300                 
Glu Gly Gln Gly Ile Lys Thr Asp Leu Pro Gln Tyr Ile Ile Gly Gln
305                 310                 315                 320 
Leu Gly Leu Ala Lys Asp Pro Leu Glu Glu Met Val Pro Leu Ser His
                325                 330                 335     
Leu Glu Glu Glu Gln Pro Pro Ala Pro Glu Ser Pro Glu Ser Arg Ala
            340                 345                 350         
Leu Val Gly Gln Ser Arg Arg Lys Pro Cys Glu Ser Asp Phe Glu Thr
        355                 360                 365             
Ile Lys Leu Ile Ser Asn Gly Ala Tyr Gly Ala Val Tyr Leu Val Arg
    370                 375                 380                 
His Arg Asp Thr Arg Gln Arg Phe Ala Ile Lys Lys Ile Asn Lys Gln
385                 390                 395                 400 
Asn Leu Ile Leu Arg Asn Gln Ile Gln Gln Val Phe Val Glu Arg Asp
                405                 410                 415     
Ile Leu Thr Phe Ala Glu Asn Pro Phe Val Val Ser Met Phe Cys Ser
            420                 425                 430         
Phe Glu Thr Arg Arg His Leu Cys Met Val Met Glu Tyr Val Glu Gly
        435                 440                 445             
Gly Asp Cys Ala Thr Leu Leu Lys Asn Met Gly Pro Leu Pro Val Asp
    450                 455                 460                 
Met Ala Arg Leu Tyr Phe Ala Glu Thr Val Leu Ala Leu Glu Tyr Leu
465                 470                 475                 480 
His Asn Tyr Gly Ile Val His Arg Asp Leu Lys Pro Asp Asn Leu Leu
                485                 490                 495     
Ile Thr Ser Leu Gly His Ile Lys Leu Thr Asp Phe Gly Leu Ser Lys
            500                 505                 510         
Ile Gly Leu Met Ser Met Ala Thr Asn Leu Tyr Glu Gly His Ile Glu
        515                 520                 525             
Lys Asp Ala Arg Glu Phe Ile Asp Lys Gln Val Cys Gly Thr Pro Glu
    530                 535                 540                 
Tyr Ile Ala Pro Glu Val Ile Phe Arg Gln Gly Tyr Gly Lys Pro Val
545                 550                 555                 560 
Asp Trp Trp Ala Met Gly Val Val Leu Tyr Glu Phe Leu Val Gly Cys
                565                 570                 575     
Val Pro Phe Phe Gly Asp Thr Pro Glu Glu Leu Phe Gly Gln Val Val
            580                 585                 590         
Ser Asp Glu Ile Met Trp Pro Glu Gly Asp Glu Ala Leu Pro Ala Asp
        595                 600                 605             
Ala Gln Asp Leu Ile Thr Arg Leu Leu Arg Gln Ser Pro Leu Asp Arg
    610                 615                 620                 
Leu Gly Thr Gly Gly Thr His Glu Val Lys Gln His Pro Phe Phe Leu
625                 630                 635                 640 
Ala Leu Asp Trp Ala Gly Leu Leu Arg His Lys Ala Glu Phe Val Pro
                645                 650                 655     
Gln Leu Glu Ala Glu Asp Asp Thr Ser Tyr Phe Asp Thr Arg Ser Glu
            660                 665                 670         
Arg Tyr Arg His Leu Gly Ser Glu Asp Asp Glu Thr Asn Asp Glu Glu
        675                 680                 685             
Ser Ser Thr Glu Ile Pro Gln Phe Ser Ser Cys Ser His Arg Phe Ser
    690                 695                 700                 
Lys Val Tyr Ser Ser Ser Glu Phe Leu Ala Val Gln Pro Thr Pro Thr
705                 710                 715                 720 
Phe Ala Glu Arg Ser Phe Ser Glu Asp Arg Glu Glu Gly Trp Glu Arg
                725                 730                 735     
Ser Glu Val Asp Tyr Gly Arg Arg Leu Ser Ala Asp Ile Arg Leu Arg
            740                 745                 750         
Ser Trp Thr Ser Ser Gly Ser Ser Cys Gln Ser Ser Ser Ser Gln Pro
        755                 760                 765             
Glu Arg Gly Pro Ser Pro Ser Leu Leu Asn Thr Ile Ser Leu Asp Thr
    770                 775                 780                 
Met Pro Lys Phe Ala Phe Ser Ser Glu Asp Glu Gly Val Gly Pro Gly
785                 790                 795                 800 
Pro Ala Gly Pro Lys Arg Pro Val Phe Ile Leu Gly Glu Pro Asp Pro
                805                 810                 815     
Pro Pro Ala Ala Thr Pro Val Met Pro Lys Pro Ser Ser Leu Ser Ala
            820                 825                 830         
Asp Thr Ala Ala Leu Ser His Ala Arg Leu Arg Ser Asn Ser Ile Gly
        835                 840                 845             
Ala Arg His Ser Thr Pro Arg Pro Leu Asp Ala Gly Arg Gly Arg Arg
    850                 855                 860                 
Leu Gly Gly Pro Arg Asp Pro Ala Pro Glu Lys Ser Arg Ala Ser Ser
865                 870                 875                 880 
Ser Gly Gly Ser Gly Gly Gly Ser Gly Gly Arg Val Pro Lys Ser Ala
                885                 890                 895     
Ser Val Ser Ala Leu Ser Leu Ile Ile Thr Ala Asp Asp Gly Ser Gly
            900                 905                 910         
Gly Pro Leu Met Ser Pro Leu Ser Pro Arg Ser Leu Ser Ser Asn Pro
        915                 920                 925             
Ser Ser Arg Asp Ser Ser Pro Ser Arg Asp Pro Ser Pro Val Cys Gly
    930                 935                 940                 
Ser Leu Arg Pro Pro Ile Val Ile His Ser Ser Gly Lys Lys Tyr Gly
945                 950                 955                 960 
Phe Ser Leu Arg Ala Ile Arg Val Tyr Met Gly Asp Ser Asp Val Tyr
                965                 970                 975     
Thr Val His His Val Val Trp Ser Val Glu Asp Gly Ser Pro Ala Gln
            980                 985                 990         
Glu Ala Gly Leu Arg Ala Gly Asp Leu Ile Thr His Ile Asn Gly Glu
        995                 1000                1005            
Ser Val Leu Gly Leu Val His Met Asp Val Val Glu Leu Leu Leu Lys
    1010                1015                1020                
Ser Gly Asn Lys Ile Ser Leu Arg Thr Thr Ala Leu Glu Asn Thr Ser
1025                1030                1035                1040
Ile Lys Val Gly Pro Ala Arg Lys Asn Val Ala Lys Gly Arg Met Ala
                1045                1050                1055    
Arg Arg Ser Lys Arg Ser Arg Arg Arg Glu Thr Gln Asp Arg Arg Lys
            1060                1065                1070        
Ser Leu Phe Lys Lys Ile Ser Lys Gln Thr Ser Val Leu His Thr Ser
        1075                1080                1085            
Arg Ser Phe Ser Ser Gly Leu His His Ser Leu Ser Ser Ser Glu Ser
    1090                1095                1100                
Leu Pro Gly Ser Pro Thr His Ser Leu Ser Pro Ser Pro Thr Thr Pro
1105                1110                1115                1120
Cys Arg Ser Pro Ala Pro Asp Val Pro Ala Asp Thr Thr Ala Ser Pro
                1125                1130                1135    
Pro Ser Ala Ser Pro Ser Ser Ser Ser Pro Ala Ser Pro Ala Ala Ala
            1140                1145                1150        
Gly His Thr Arg Pro Ser Ser Leu His Gly Leu Ala Ala Lys Leu Gly
        1155                1160                1165            
Pro Pro Arg Pro Lys Thr Gly Arg Arg Lys Ser Thr Ser Ser Ile Pro
    1170                1175                1180                
Pro Ser Pro Leu Ala Cys Pro Pro Ile Ser Ala Pro Pro Pro Arg Ser
1185                1190                1195                1200
Pro Ser Pro Leu Pro Gly His Pro Pro Ala Pro Ala Arg Ser Pro Arg
                1205                1210                1215    
Leu Arg Arg Gly Gln Ser Ala Asp Lys Leu Gly Thr Gly Glu Arg Leu
            1220                1225                1230        
Asp Gly Glu Ala Gly Arg Arg Thr Arg Gly Pro Glu Ala Glu Leu Val
        1235                1240                1245            
Val Met Arg Arg Leu His Leu Ser Glu Arg Arg Asp Ser Phe Lys Lys
    1250                1255                1260                
Gln Glu Ala Val Gln Glu Val Ser Phe Asp Glu Pro Gln Glu Glu Ala
1265                1270                1275                1280
Thr Gly Leu Pro Thr Ser Val Pro Gln Ile Ala Val Glu Gly Glu Glu
                1285                1290                1295    
Ala Val Pro Val Ala Leu Gly Pro Thr Gly Arg Asp
            1300                1305            


<210> 309
<211> 161
<212> PRT
<213> Homo sapiens

<400> 309
Cys Met Glu Lys Ile Ala Pro Thr Glu Phe Val Met Arg Ala Leu Glu
 1               5                  10                  15      
Cys Val Tyr His Leu Gly Cys Phe Cys Cys Cys Val Cys Glu Arg Gln
            20                  25                  30          
Leu Arg Lys Gly Asp Glu Phe Val Leu Lys Glu Gly Gln Leu Leu Cys
        35                  40                  45              
Lys Gly Asp Tyr Glu Lys Glu Lys Asp Leu Leu Ser Ser Val Ser Pro
    50                  55                  60                  
Asp Glu Ser Asp Ser Val Lys Ser Glu Asp Glu Asp Gly Asp Met Lys
65                  70                  75                  80  
Pro Ala Lys Gly Gln Gly Ser Gln Ser Lys Gly Ser Gly Asp Asp Gly
                85                  90                  95      
Lys Asp Pro Arg Arg Pro Lys Arg Pro Arg Thr Ile Leu Thr Thr Gln
            100                 105                 110         
Gln Arg Arg Ala Phe Lys Ala Ser Phe Glu Val Ser Ser Lys Pro Cys
        115                 120                 125             
Arg Lys Val Arg Glu Thr Leu Ala Ala Glu Thr Gly Leu Ser Val Arg
    130                 135                 140                 
Val Val Gln Val Trp Phe Gln Asn Gln Arg Ala Lys Met Lys Lys Leu
145                 150                 155                 160 
Ala
    


<210> 310
<211> 141
<212> PRT
<213> Homo sapiens

<400> 310
Val Leu Ser Pro Ala Asp Lys Thr Asn Val Lys Ala Ala Trp Gly Lys
 1               5                  10                  15      
Val Gly Ala His Ala Gly Glu Tyr Gly Ala Glu Ala Leu Glu Arg Met
            20                  25                  30          
Phe Leu Ser Phe Pro Thr Thr Lys Thr Tyr Phe Pro His Phe Asp Leu
        35                  40                  45              
Ser His Gly Ser Ala Gln Val Lys Gly His Gly Lys Lys Val Ala Asp
    50                  55                  60                  
Ala Leu Thr Asn Ala Val Ala His Val Asp Asp Met Pro Asn Ala Leu
65                  70                  75                  80  
Ser Ala Leu Ser Asp Leu His Ala His Lys Leu Arg Val Asp Pro Trp
                85                  90                  95      
Asn Phe Lys Leu Leu Ser His Cys Leu Leu Val Thr Leu Ala Ala His
            100                 105                 110         
Leu Pro Ala Glu Phe Thr Pro Ala Val His Ala Ser Leu Asp Lys Phe
        115                 120                 125             
Leu Ala Ser Val Ser Thr Val Leu Thr Ser Lys Tyr Arg
    130                 135                 140     


<210> 311
<211> 231
<212> PRT
<213> Homo sapiens

<400> 311
Gly Arg His Val Arg Asn Leu His Lys Thr Ala Met Gln Asn Gly Ala
 1               5                  10                  15      
Gly Gly Ala Leu Phe Val His Arg Asp Thr Pro Glu Asn Asn Pro Asp
            20                  25                  30          
Thr Pro Phe Asp Phe Thr Pro Glu Asn Tyr Lys Arg Ile Glu Ala Ile
        35                  40                  45              
Val Lys Asn Tyr Pro Glu Gly His Lys Ala Ala Ala Val Leu Pro Val
    50                  55                  60                  
Leu Asp Leu Ala Gln Arg Gln Asn Gly Trp Leu Pro Ile Ser Ala Met
65                  70                  75                  80  
Asn Lys Val Ala Glu Val Leu Gln Val Pro Pro Met Arg Val Tyr Glu
                85                  90                  95      
Val Ala Thr Phe Tyr Thr Met Tyr Asn Arg Lys Pro Val Gly Lys Tyr
            100                 105                 110         
Tyr Ile Gln Val Cys Thr Thr Thr Pro Cys Met Leu Arg Asn Ser Asp
        115                 120                 125             
Ser Ile Leu Glu Ala Ile Gln Lys Lys Leu Gly Ile Lys Val Gly Glu
    130                 135                 140                 
Thr Thr Pro Asp Lys Leu Phe Thr Leu Ile Glu Val Glu Cys Leu Gly
145                 150                 155                 160 
Ala Cys Val Asn Ala Pro Met Val Gln Ile Asn Asp Asn Tyr Tyr Glu
                165                 170                 175     
Asp Leu Thr Ala Lys Asp Ile Glu Glu Ile Ile Asp Glu Leu Lys Ala
            180                 185                 190         
Gly Lys Ile Pro Lys Pro Gly Pro Arg Ser Gly Arg Phe Ser Cys Glu
        195                 200                 205             
Pro Ala Gly Gly Leu Thr Ser Leu Thr Glu Pro Pro Lys Gly Pro Gly
    210                 215                 220                 
Phe Gly Val Gln Ala Gly Leu
225                 230     


<210> 312
<211> 84
<212> PRT
<213> Homo sapiens

<400> 312
Val Lys Gln Ile Glu Ser Lys Thr Ala Phe Gln Glu Ala Leu Asp Ala
 1               5                  10                  15      
Ala Gly Asp Lys Leu Val Val Val Asp Phe Ser Ala Thr Trp Cys Gly
            20                  25                  30          
Pro Cys Lys Met Ile Lys Pro Phe Phe His Asp Val Ala Ser Glu Cys
        35                  40                  45              
Glu Val Lys Cys Met Pro Thr Phe Gln Phe Phe Lys Lys Gly Gln Lys
    50                  55                  60                  
Val Gly Glu Phe Ser Gly Ala Asn Lys Glu Lys Leu Glu Ala Thr Ile
65                  70                  75                  80  
Asn Glu Leu Val
                


<210> 313
<211> 1021
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 951
<223> Xaa = Any Amino Acid

<400> 313
Arg Leu Arg Leu Leu Leu Leu Glu Ser Val Ser Gly Leu Leu Gln Pro
 1               5                  10                  15      
Arg Thr Gly Ser Ala Val Ala Pro Val His Pro Pro Asn Arg Ser Ala
            20                  25                  30          
Pro His Leu Pro Gly Leu Met Cys Leu Leu Arg Leu His Gly Ser Val
        35                  40                  45              
Gly Gly Ala Gln Asn Leu Ser Ala Leu Gly Ala Leu Val Ser Leu Ser
    50                  55                  60                  
Asn Ala Arg Leu Ser Ser Ile Lys Thr Arg Phe Glu Gly Leu Cys Leu
65                  70                  75                  80  
Leu Ser Leu Leu Val Gly Glu Ser Pro Thr Glu Leu Phe Gln Gln His
                85                  90                  95      
Cys Val Ser Trp Leu Arg Ser Ile Gln Gln Val Leu Gln Thr Gln Asp
            100                 105                 110         
Pro Pro Ala Thr Met Glu Leu Ala Val Ala Val Leu Arg Asp Leu Leu
        115                 120                 125             
Arg Tyr Ala Ala Gln Leu Pro Ala Leu Phe Arg Asp Ile Ser Met Asn
    130                 135                 140                 
His Leu Pro Gly Leu Leu Thr Ser Leu Leu Gly Leu Arg Pro Glu Cys
145                 150                 155                 160 
Glu Gln Ser Ala Leu Glu Gly Met Lys Ala Cys Met Thr Tyr Phe Pro
                165                 170                 175     
Arg Ala Cys Gly Ser Leu Lys Gly Lys Leu Ala Ser Phe Phe Leu Ser
            180                 185                 190         
Arg Val Asp Ala Leu Ser Pro Gln Leu Gln Gln Leu Ala Cys Glu Cys
        195                 200                 205             
Tyr Ser Arg Leu Pro Ser Leu Gly Ala Gly Phe Ser Gln Gly Leu Lys
    210                 215                 220                 
His Thr Glu Ser Trp Glu Gln Glu Leu His Ser Leu Leu Ala Ser Leu
225                 230                 235                 240 
His Thr Leu Leu Gly Ala Leu Tyr Glu Gly Ala Glu Thr Ala Pro Val
                245                 250                 255     
Gln Asn Glu Gly Pro Gly Val Glu Met Leu Leu Ser Ser Glu Asp Gly
            260                 265                 270         
Asp Ala His Val Leu Leu Gln Leu Arg Gln Arg Phe Ser Gly Leu Ala
        275                 280                 285             
Arg Cys Leu Gly Leu Met Leu Ser Ser Glu Phe Gly Ala Pro Val Ser
    290                 295                 300                 
Val Pro Val Gln Glu Ile Leu Asp Phe Ile Cys Arg Thr Leu Ser Val
305                 310                 315                 320 
Ser Ser Lys Asn Ile Ser Leu His Gly Asp Gly Pro Cys Gly Cys Cys
                325                 330                 335     
Cys Cys Pro Leu Ser Thr Leu Lys Ala Leu Asp Leu Leu Ser Ala Leu
            340                 345                 350         
Ile Leu Ala Cys Gly Ser Arg Leu Leu Arg Phe Gly Ile Leu Ile Gly
        355                 360                 365             
Arg Leu Leu Pro Gln Val Leu Asn Ser Trp Ser Ile Gly Arg Asp Ser
    370                 375                 380                 
Leu Ser Pro Gly Gln Glu Arg Pro Tyr Ser Thr Val Arg Thr Lys Val
385                 390                 395                 400 
Tyr Ala Ile Leu Glu Leu Trp Val Gln Val Cys Gly Ala Ser Ala Gly
                405                 410                 415     
Met Leu Gln Gly Gly Ala Ser Gly Glu Ala Leu Leu Thr His Leu Leu
            420                 425                 430         
Ser Asp Ile Ser Pro Pro Ala Asp Ala Leu Lys Leu Arg Ser Pro Arg
        435                 440                 445             
Gly Ser Pro Asp Gly Ser Leu Gln Thr Gly Lys Pro Ser Ala Pro Lys
    450                 455                 460                 
Lys Leu Lys Leu Asp Val Gly Glu Ala Met Ala Pro Pro Ser His Leu
465                 470                 475                 480 
Leu Leu Pro Val Pro Cys Lys Pro Ser Pro Ser Ala Ser Glu Lys Ile
                485                 490                 495     
Ala Leu Arg Ser Pro Leu Ser Cys Ser Glu Ala Leu Val Thr Cys Ala
            500                 505                 510         
Ala Leu Thr His Pro Arg Val Pro Pro Leu Gln Pro Met Gly Pro Thr
        515                 520                 525             
Cys Pro Thr Pro Ala Pro Val Pro Leu Leu Arg Pro His Arg Pro Ser
    530                 535                 540                 
Gly Pro His Arg Ser Ile Leu Arg Ala Pro Cys Pro Gln Trp Ala Pro
545                 550                 555                 560 
Cys Pro Gln Gln Ala Pro Cys Pro Ser Ala Gly Pro Met Pro Ser Ala
                565                 570                 575     
Gly Pro Val Pro Ser Glu Pro Trp Thr Ser Thr Thr Ala Asn Leu Leu
            580                 585                 590         
Gly Leu Leu Ser Arg Pro Ser Val Cys Pro Pro Arg Leu Leu Pro Gly
        595                 600                 605             
Pro Glu Asn His Arg Ala Gly Ser Asn Glu Asp Pro Ile Leu Ala Pro
    610                 615                 620                 
Ser Gly Thr Pro Pro Pro Thr Ile Pro Pro Asp Glu Thr Phe Gly Gly
625                 630                 635                 640 
Arg Val Pro Arg Pro Ala Phe Val His Tyr Asp Lys Glu Glu Ala Ser
                645                 650                 655     
Asp Val Glu Ile Ser Leu Glu Ser Asp Ser Asp Asp Ser Val Val Ile
            660                 665                 670         
Val Pro Glu Gly Leu Pro Pro Leu Pro Pro Pro Pro Pro Ser Gly Ala
        675                 680                 685             
Thr Pro Pro Pro Ile Ala Pro Thr Gly Pro Pro Thr Ala Ser Pro Pro
    690                 695                 700                 
Val Pro Ala Lys Glu Glu Pro Glu Glu Leu Pro Ala Ala Pro Gly Pro
705                 710                 715                 720 
Leu Pro Pro Pro Pro Pro Pro Pro Pro Pro Val Pro Gly Pro Val Thr
                725                 730                 735     
Leu Pro Pro Pro Gln Leu Val Pro Glu Gly Thr Pro Gly Gly Gly Gly
            740                 745                 750         
Pro Pro Ala Leu Glu Glu Asp Leu Thr Val Ile Asn Ile Asn Ser Ser
        755                 760                 765             
Asp Glu Glu Glu Glu Glu Glu Gly Glu Glu Glu Glu Glu Glu Glu Glu
    770                 775                 780                 
Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp
785                 790                 795                 800 
Phe Glu Glu Glu Glu Glu Asp Glu Glu Glu Tyr Phe Glu Glu Glu Glu
                805                 810                 815     
Glu Glu Glu Glu Glu Phe Glu Glu Glu Phe Glu Glu Glu Glu Gly Glu
            820                 825                 830         
Leu Glu Glu Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu Glu Glu Leu
        835                 840                 845             
Glu Glu Val Glu Asp Leu Glu Phe Gly Thr Ala Gly Gly Glu Val Glu
    850                 855                 860                 
Glu Gly Ala Pro Pro Pro Pro Thr Leu Pro Pro Ala Leu Pro Pro Pro
865                 870                 875                 880 
Glu Ser Pro Pro Lys Val Gln Pro Glu Pro Glu Pro Glu Pro Gly Leu
                885                 890                 895     
Leu Leu Glu Val Glu Glu Pro Gly Thr Glu Glu Glu Arg Gly Ala Asp
            900                 905                 910         
Thr Ala Pro Thr Leu Ala Pro Glu Ala Leu Pro Ser Gln Gly Glu Val
        915                 920                 925             
Glu Arg Glu Gly Glu Ser Pro Ala Ala Gly Pro Pro Pro Gln Glu Leu
    930                 935                 940                 
Val Glu Glu Glu Pro Ser Xaa Pro Pro Thr Leu Leu Glu Glu Glu Thr
945                 950                 955                 960 
Glu Asp Gly Ser Asp Lys Val Gln Pro Pro Pro Glu Thr Pro Ala Glu
                965                 970                 975     
Glu Glu Met Glu Thr Glu Thr Glu Ala Glu Ala Leu Gln Glu Lys Glu
            980                 985                 990         
Gln Asp Asp Thr Ala Ala Met Leu Ala Asp Phe Ile Asp Cys Pro Pro
        995                 1000                1005            
Asp Asp Glu Lys Pro Pro Pro Pro Thr Glu Pro Asp Ser
    1010                1015                1020    


<210> 314
<211> 334
<212> PRT
<213> Homo sapiens

<400> 314
Met Gly Tyr Ala Arg Thr Ile Leu Glu Glu Asn Ile Gln Asp Gln Asp
 1               5                  10                  15      
Val Leu Leu Leu Ile Lys Lys Arg Ala Pro Ser Pro Leu Pro Lys Met
            20                  25                  30          
Ala Asp Val Ser Ala Glu Glu Lys Lys Lys Gln Asp Gln Lys Ala Pro
        35                  40                  45              
Asp Lys Glu Ala Ile Leu Arg Ala Thr Ala Asn Leu Pro Ser Tyr Asn
    50                  55                  60                  
Met Asp Arg Ala Ala Val Gln Thr Asn Met Arg Asp Phe Gln Thr Glu
65                  70                  75                  80  
Leu Arg Lys Ile Leu Val Ser Leu Ile Glu Val Ala Gln Lys Leu Leu
                85                  90                  95      
Ala Leu Asn Pro Asp Ala Val Glu Leu Phe Lys Lys Ala Asn Ala Met
            100                 105                 110         
Leu Asp Glu Asp Glu Asp Glu Arg Val Asp Glu Ala Ala Leu Arg Gln
        115                 120                 125             
Leu Thr Glu Met Gly Phe Pro Glu Asn Arg Ala Thr Lys Ala Leu Gln
    130                 135                 140                 
Leu Asn His Met Ser Val Pro Gln Ala Met Glu Trp Leu Ile Glu His
145                 150                 155                 160 
Ala Glu Asp Pro Thr Ile Asp Thr Pro Leu Pro Gly Arg Ala Pro Pro
                165                 170                 175     
Glu Ala Glu Gly Ala Thr Ala Ala Ala Ser Glu Ala Ala Ala Gly Ala
            180                 185                 190         
Ser Ala Thr Asp Glu Glu Ala Arg Asp Glu Leu Thr Glu Ile Phe Lys
        195                 200                 205             
Lys Ile Arg Arg Lys Arg Glu Phe Arg Ala Asp Ala Arg Ala Val Ile
    210                 215                 220                 
Ser Leu Met Glu Met Gly Phe Asp Glu Lys Glu Val Ile Asp Ala Leu
225                 230                 235                 240 
Arg Val Asn Asn Asn Gln Gln Asn Ala Ala Cys Glu Trp Leu Leu Gly
                245                 250                 255     
Asp Arg Lys Pro Ser Pro Glu Glu Leu Asp Lys Gly Ile Asp Pro Asp
            260                 265                 270         
Ser Pro Leu Phe Gln Ala Ile Leu Asp Asn Pro Val Val Gln Leu Gly
        275                 280                 285             
Leu Thr Asn Pro Lys Thr Leu Leu Ala Phe Glu Asp Met Leu Glu Asn
    290                 295                 300                 
Pro Leu Asn Ser Thr Gln Trp Met Asn Asp Pro Glu Thr Gly Pro Val
305                 310                 315                 320 
Met Leu Gln Ile Ser Arg Ile Phe Gln Thr Leu Asn Arg Thr
                325                 330                 


<210> 315
<211> 998
<212> PRT
<213> Homo sapiens

<400> 315
Met Glu Ala Ala His Leu Leu Pro Ala Ala Asp Val Leu Arg His Phe
 1               5                  10                  15      
Ser Val Thr Ala Glu Gly Gly Leu Ser Pro Ala Gln Val Thr Gly Ala
            20                  25                  30          
Arg Glu Arg Tyr Gly Pro Asn Glu Leu Pro Ser Glu Glu Gly Lys Ser
        35                  40                  45              
Leu Trp Glu Leu Val Leu Glu Gln Phe Glu Asp Leu Leu Val Arg Ile
    50                  55                  60                  
Leu Leu Leu Ala Ala Leu Val Ser Phe Val Leu Ala Trp Phe Glu Glu
65                  70                  75                  80  
Gly Glu Glu Thr Thr Thr Ala Phe Val Glu Pro Leu Val Ile Met Leu
                85                  90                  95      
Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala
            100                 105                 110         
Glu Ser Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys
        115                 120                 125             
Val Ile Arg Ser Asp Arg Lys Gly Val Gln Arg Ile Arg Ala Arg Asp
    130                 135                 140                 
Ile Val Pro Gly Asp Ile Val Glu Val Ala Val Gly Asp Lys Val Pro
145                 150                 155                 160 
Ala Asp Leu Arg Leu Ile Glu Ile Lys Ser Thr Thr Leu Arg Val Asp
                165                 170                 175     
Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Thr Lys His Thr Glu
            180                 185                 190         
Ala Ile Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu
        195                 200                 205             
Phe Ser Gly Thr Asn Ile Thr Ser Gly Lys Ala Val Gly Val Ala Val
    210                 215                 220                 
Ala Thr Gly Leu His Thr Glu Leu Gly Lys Ile Arg Ser Gln Met Ala
225                 230                 235                 240 
Ala Val Glu Pro Glu Arg Thr Pro Leu Gln Arg Lys Leu Asp Glu Phe
                245                 250                 255     
Gly Arg Gln Leu Ser His Ala Ile Ser Val Ile Cys Val Ala Val Trp
            260                 265                 270         
Val Ile Asn Ile Gly His Phe Ala Asp Pro Ala His Gly Gly Ser Trp
        275                 280                 285             
Leu Arg Gly Ala Val Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val
    290                 295                 300                 
Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala
305                 310                 315                 320 
Leu Gly Thr Arg Arg Met Ala Arg Lys Asn Ala Ile Val Arg Ser Leu
                325                 330                 335     
Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys
            340                 345                 350         
Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Val
        355                 360                 365             
Val Ala Glu Ala Asp Ala Gly Ser Cys Leu Leu His Glu Phe Thr Ile
    370                 375                 380                 
Ser Gly Thr Thr Tyr Thr Pro Glu Gly Glu Val Arg Gln Gly Asp Gln
385                 390                 395                 400 
Pro Val Arg Cys Gly Gln Phe Asp Gly Leu Val Glu Leu Ala Thr Ile
                405                 410                 415     
Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly
            420                 425                 430         
Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu
        435                 440                 445             
Val Glu Lys Met Asn Val Phe Asp Thr Asp Leu Gln Ala Leu Ser Arg
    450                 455                 460                 
Val Glu Arg Ala Gly Ala Cys Asn Thr Val Ile Lys Gln Leu Met Arg
465                 470                 475                 480 
Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val
                485                 490                 495     
Tyr Cys Thr Pro Thr Arg Pro His Pro Thr Gly Gln Gly Ser Lys Met
            500                 505                 510         
Phe Val Lys Gly Ala Pro Glu Ser Val Ile Glu Arg Cys Ser Ser Val
        515                 520                 525             
Arg Val Gly Ser Arg Thr Ala Pro Leu Thr Pro Thr Ser Arg Glu Gln
    530                 535                 540                 
Ile Leu Ala Lys Ile Arg Asp Trp Gly Ser Gly Ser Asp Thr Leu Arg
545                 550                 555                 560 
Cys Leu Ala Leu Ala Thr Arg Asp Ala Pro Pro Arg Lys Glu Asp Met
                565                 570                 575     
Glu Leu Asp Asp Cys Ser Lys Phe Val Gln Tyr Glu Thr Asp Leu Thr
            580                 585                 590         
Phe Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Pro Glu Val Ala
        595                 600                 605             
Ala Cys Ile Thr Arg Cys Tyr Gln Ala Gly Ile Arg Val Val Met Ile
    610                 615                 620                 
Thr Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Leu Gly
625                 630                 635                 640 
Ile Phe Gly Asp Thr Glu Asp Val Ala Gly Lys Ala Tyr Thr Gly Arg
                645                 650                 655     
Glu Phe Asp Asp Leu Ser Pro Glu Gln Gln Arg Gln Ala Cys Arg Thr
            660                 665                 670         
Thr Arg Cys Phe Ala Arg Val Glu Pro Ala His Lys Ser Arg Ile Val
        675                 680                 685             
Glu Asn Leu Gln Ser Phe Asn Glu Ile Thr Ala Met Thr Gly Asp Gly
    690                 695                 700                 
Val Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met
705                 710                 715                 720 
Gly Ser Gly Thr Ala Val Ala Lys Ser Ala Ala Glu Met Val Leu Ser
                725                 730                 735     
Asp Asp Asn Phe Ala Ser Ile Val Ala Ala Val Glu Glu Gly Arg Ala
            740                 745                 750         
Ile Tyr Ser Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn
        755                 760                 765             
Val Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ile Leu Gly Leu Pro
    770                 775                 780                 
Glu Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp
785                 790                 795                 800 
Gly Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile
                805                 810                 815     
Met Glu Lys Leu Pro Arg Ser Pro Arg Glu Ala Leu Ile Ser Gly Trp
            820                 825                 830         
Leu Phe Phe Arg Tyr Leu Ala Ile Gly Val Tyr Val Gly Leu Ala Thr
        835                 840                 845             
Val Ala Ala Ala Thr Trp Trp Phe Val Tyr Asp Ala Glu Gly Pro His
    850                 855                 860                 
Ile Asn Phe Tyr Gln Leu Arg Asn Phe Leu Lys Cys Ser Glu Asp Asn
865                 870                 875                 880 
Pro Leu Phe Ala Gly Ile Asp Cys Glu Val Phe Glu Ser Arg Phe Pro
                885                 890                 895     
Thr Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala
            900                 905                 910         
Leu Asn Ser Val Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp
        915                 920                 925             
Met Asn Pro Trp Leu Leu Val Ala Val Ala Met Ser Met Ala Leu His
    930                 935                 940                 
Phe Leu Ile Leu Leu Val Pro Pro Leu Pro Leu Ile Phe Gln Val Thr
945                 950                 955                 960 
Pro Leu Ser Gly Arg Gln Trp Val Val Val Leu Gln Ile Ser Leu Pro
                965                 970                 975     
Val Ile Leu Leu Asp Glu Ala Leu Lys Tyr Leu Ser Arg Asn His Met
            980                 985                 990         
His Glu Met Ser Gln Lys
        995             


<210> 316
<211> 394
<212> PRT
<213> Homo sapiens

<400> 316
His Ser Leu Leu Pro Val Asp Asp Ala Ile Asn Gly Leu Ser Glu Glu
 1               5                  10                  15      
Gln Arg Gln Leu Arg Gln Thr Met Ala Lys Phe Leu Gln Glu His Leu
            20                  25                  30          
Ala Pro Lys Ala Gln Glu Ile Asp Arg Ser Asn Glu Phe Lys Asn Leu
        35                  40                  45              
Arg Glu Phe Trp Lys Gln Leu Gly Asn Leu Gly Val Leu Gly Ile Thr
    50                  55                  60                  
Ala Pro Val Gln Tyr Gly Gly Ser Gly Leu Gly Tyr Leu Glu His Val
65                  70                  75                  80  
Leu Val Met Glu Glu Ile Ser Arg Ala Ser Gly Ala Val Gly Leu Ser
                85                  90                  95      
Tyr Gly Ala His Ser Asn Leu Cys Ile Asn Gln Leu Val Arg Asn Gly
            100                 105                 110         
Asn Glu Ala Gln Lys Glu Lys Tyr Leu Pro Lys Leu Ile Ser Gly Glu
        115                 120                 125             
Tyr Ile Gly Ala Leu Ala Met Ser Glu Pro Asn Ala Gly Ser Asp Val
    130                 135                 140                 
Val Ser Met Lys Leu Lys Ala Glu Lys Lys Gly Asn His Tyr Ile Leu
145                 150                 155                 160 
Asn Gly Asn Lys Phe Trp Ile Thr Asn Gly Pro Asp Ala Asp Val Leu
                165                 170                 175     
Ile Val Tyr Ala Lys Thr Asp Leu Ala Ala Val Pro Ala Ser Arg Gly
            180                 185                 190         
Ile Thr Ala Phe Ile Val Glu Lys Gly Met Pro Gly Phe Ser Thr Ser
        195                 200                 205             
Lys Lys Leu Asp Lys Leu Gly Met Arg Gly Ser Asn Thr Cys Glu Leu
    210                 215                 220                 
Ile Phe Glu Asp Cys Lys Ile Pro Ala Ala Asn Ile Leu Gly His Glu
225                 230                 235                 240 
Asn Lys Gly Val Tyr Val Leu Met Ser Gly Leu Asp Leu Glu Arg Leu
                245                 250                 255     
Val Leu Ala Gly Gly Pro Leu Gly Leu Met Gln Ala Val Leu Asp His
            260                 265                 270         
Thr Ile Pro Tyr Leu His Val Arg Glu Ala Phe Gly Gln Lys Ile Gly
        275                 280                 285             
His Phe Gln Leu Met Gln Gly Lys Met Ala Asp Met Tyr Thr Arg Leu
    290                 295                 300                 
Met Ala Cys Arg Gln Tyr Val Tyr Asn Val Ala Lys Ala Cys Asp Glu
305                 310                 315                 320 
Gly His Cys Thr Ala Lys Asp Cys Ala Gly Val Ile Leu Tyr Ser Ala
                325                 330                 335     
Glu Cys Ala Thr Gln Val Ala Leu Asp Gly Ile Gln Cys Phe Gly Gly
            340                 345                 350         
Asn Gly Tyr Ile Asn Asp Phe Pro Met Gly Arg Phe Leu Arg Asp Ala
        355                 360                 365             
Lys Leu Tyr Glu Ile Gly Ala Gly Thr Ser Glu Val Arg Arg Leu Val
    370                 375                 380                 
Ile Gly Arg Ala Phe Asn Ala Asp Phe His
385                 390                 


<210> 317
<211> 318
<212> PRT
<213> Homo sapiens

<400> 317
Met Ala Ala Ala Ala Val Ser Gly Ala Leu Gly Arg Ala Gly Trp Arg
 1               5                  10                  15      
Leu Leu Gln Leu Arg Cys Leu Pro Val Ala Arg Cys Arg Gln Ala Leu
            20                  25                  30          
Val Pro Arg Ala Phe His Ala Ser Ala Val Gly Leu Arg Ser Ser Asp
        35                  40                  45              
Glu Gln Lys Gln Gln Pro Pro Asn Ser Phe Ser Gln Gln His Ser Glu
    50                  55                  60                  
Thr Gln Gly Ala Glu Lys Pro Asp Pro Glu Ser Ser His Ser Pro Pro
65                  70                  75                  80  
Arg Tyr Thr Asp Gln Gly Gly Glu Glu Glu Glu Asp Tyr Glu Ser Glu
                85                  90                  95      
Glu Gln Leu Gln His Arg Ile Leu Thr Ala Ala Leu Glu Phe Val Pro
            100                 105                 110         
Ala His Gly Trp Thr Ala Glu Ala Ile Ala Glu Gly Ala Gln Ser Leu
        115                 120                 125             
Gly Leu Ser Ser Ala Ala Ala Ser Met Phe Gly Lys Asp Gly Ser Glu
    130                 135                 140                 
Leu Ile Leu His Phe Val Thr Gln Cys Asn Thr Arg Leu Thr Arg Val
145                 150                 155                 160 
Leu Glu Glu Glu Gln Lys Leu Val Gln Leu Gly Gln Ala Glu Lys Arg
                165                 170                 175     
Lys Thr Asp Gln Phe Leu Arg Asp Ala Val Glu Thr Arg Leu Arg Met
            180                 185                 190         
Leu Ile Pro Tyr Ile Glu His Trp Pro Arg Ala Leu Ser Ile Leu Met
        195                 200                 205             
Leu Pro His Asn Ile Pro Ser Ser Leu Ser Leu Leu Thr Ser Met Val
    210                 215                 220                 
Asp Asp Met Trp His Tyr Ala Gly Asp Gln Ser Thr Asp Phe Asn Trp
225                 230                 235                 240 
Tyr Thr Arg Arg Ala Met Leu Ala Ala Ile Tyr Asn Thr Thr Glu Leu
                245                 250                 255     
Val Met Met Gln Asp Ser Ser Pro Asp Phe Glu Asp Thr Trp Arg Phe
            260                 265                 270         
Leu Glu Asn Arg Val Asn Asp Ala Met Asn Met Gly His Thr Ala Lys
        275                 280                 285             
Gln Val Lys Ser Thr Gly Glu Ala Leu Val Gln Gly Leu Met Gly Ala
    290                 295                 300                 
Ala Val Thr Leu Lys Asn Leu Thr Gly Leu Asn Gln Arg Arg
305                 310                 315             


<210> 318
<211> 318
<212> PRT
<213> Homo sapiens

<400> 318
Met Ala Ala Ala Ala Val Ser Gly Ala Leu Gly Arg Ala Gly Trp Arg
 1               5                  10                  15      
Leu Leu Gln Leu Arg Cys Leu Pro Val Ala Arg Cys Arg Gln Ala Leu
            20                  25                  30          
Val Pro Arg Ala Phe His Ala Ser Ala Val Gly Leu Arg Ser Ser Asp
        35                  40                  45              
Glu Gln Lys Gln Gln Pro Pro Asn Ser Phe Ser Gln Gln His Ser Glu
    50                  55                  60                  
Thr Gln Gly Ala Glu Lys Pro Asp Pro Glu Ser Ser His Ser Pro Pro
65                  70                  75                  80  
Arg Tyr Thr Asp Gln Gly Gly Glu Glu Glu Glu Asp Tyr Glu Ser Glu
                85                  90                  95      
Glu Gln Leu Gln His Arg Ile Leu Thr Ala Ala Leu Glu Phe Val Pro
            100                 105                 110         
Ala His Gly Trp Thr Ala Glu Ala Ile Ala Glu Gly Ala Gln Ser Leu
        115                 120                 125             
Gly Leu Ser Ser Ala Ala Ala Ser Met Phe Gly Lys Asp Gly Ser Glu
    130                 135                 140                 
Leu Ile Leu His Phe Val Thr Gln Cys Asn Thr Arg Leu Thr Arg Val
145                 150                 155                 160 
Leu Glu Glu Glu Gln Lys Leu Val Gln Leu Gly Gln Ala Glu Lys Arg
                165                 170                 175     
Lys Thr Asp Gln Phe Leu Arg Asp Ala Val Glu Thr Arg Leu Arg Met
            180                 185                 190         
Leu Ile Pro Tyr Ile Glu His Trp Pro Arg Ala Leu Ser Ile Leu Met
        195                 200                 205             
Leu Pro His Asn Ile Pro Ser Ser Leu Ser Leu Leu Thr Ser Met Val
    210                 215                 220                 
Asp Asp Met Trp His Tyr Ala Gly Asp Gln Ser Thr Asp Phe Asn Trp
225                 230                 235                 240 
Tyr Thr Arg Arg Ala Met Leu Ala Ala Ile Tyr Asn Thr Thr Glu Leu
                245                 250                 255     
Val Met Met Gln Asp Ser Ser Pro Asp Phe Glu Asp Thr Trp Arg Phe
            260                 265                 270         
Leu Glu Asn Arg Val Asn Asp Ala Met Asn Met Gly His Thr Ala Lys
        275                 280                 285             
Gln Val Lys Ser Thr Gly Glu Ala Leu Val Gln Gly Leu Met Gly Ala
    290                 295                 300                 
Ala Val Thr Leu Lys Asn Leu Thr Gly Leu Asn Gln Arg Arg
305                 310                 315             


<210> 319
<211> 408
<212> PRT
<213> Homo sapiens

<400> 319
Met Asp Phe Leu Leu Gly Asn Pro Phe Ser Ser Pro Val Gly Gln Arg
 1               5                  10                  15      
Ile Glu Lys Ala Thr Asp Gly Ser Leu Gln Ser Glu Asp Trp Ala Leu
            20                  25                  30          
Asn Met Glu Ile Cys Asp Ile Ile Asn Glu Thr Glu Glu Gly Pro Lys
        35                  40                  45              
Asp Ala Leu Arg Ala Val Lys Lys Arg Ile Val Gly Asn Lys Asn Phe
    50                  55                  60                  
His Glu Val Met Leu Ala Leu Thr Val Leu Glu Thr Cys Val Lys Asn
65                  70                  75                  80  
Cys Gly His Arg Phe His Val Leu Val Ala Ser Gln Asp Phe Val Glu
                85                  90                  95      
Ser Val Leu Val Arg Thr Ile Leu Pro Lys Asn Asn Pro Pro Thr Ile
            100                 105                 110         
Val His Asp Lys Val Leu Asn Leu Ile Gln Ser Trp Ala Asp Ala Phe
        115                 120                 125             
Arg Ser Ser Pro Asp Leu Thr Gly Val Val Thr Ile Tyr Glu Asp Leu
    130                 135                 140                 
Arg Arg Lys Gly Leu Glu Phe Pro Met Thr Asp Leu Asp Met Leu Ser
145                 150                 155                 160 
Pro Ile His Thr Pro Gln Arg Thr Val Phe Asn Ser Glu Thr Gln Ser
                165                 170                 175     
Gly Gln Asp Ser Val Gly Thr Asp Ser Ser Gln Gln Glu Asp Ser Gly
            180                 185                 190         
Gln His Ala Ala Pro Leu Pro Ala Pro Pro Ile Leu Ser Gly Asp Thr
        195                 200                 205             
Pro Ile Ala Pro Thr Pro Glu Gln Ile Gly Lys Leu Arg Ser Glu Leu
    210                 215                 220                 
Glu Met Val Ser Gly Asn Val Arg Val Met Ser Glu Met Leu Thr Glu
225                 230                 235                 240 
Leu Val Pro Thr Gln Ala Glu Pro Ala Asp Leu Glu Leu Leu Gln Glu
                245                 250                 255     
Leu Asn Arg Thr Cys Arg Ala Met Gln Gln Arg Val Leu Glu Leu Ile
            260                 265                 270         
Pro Gln Ile Ala Asn Glu Gln Leu Thr Glu Glu Leu Leu Ile Val Asn
        275                 280                 285             
Asp Asn Leu Asn Asn Val Phe Leu Arg His Glu Arg Phe Glu Arg Phe
    290                 295                 300                 
Arg Thr Gly Gln Thr Thr Lys Ala Pro Ser Glu Ala Glu Pro Ala Ala
305                 310                 315                 320 
Asp Leu Ile Asp Met Gly Pro Asp Pro Ala Ala Thr Gly Asn Leu Ser
                325                 330                 335     
Ser Gln Leu Ala Gly Met Asn Leu Gly Ser Ser Ser Val Arg Ala Gly
            340                 345                 350         
Leu Gln Ser Leu Glu Ala Ser Gly Arg Leu Glu Asp Glu Phe Asp Met
        355                 360                 365             
Phe Ala Leu Thr Arg Gly Ser Ser Leu Ala Asp Gln Arg Lys Glu Val
    370                 375                 380                 
Lys Tyr Glu Ala Pro Gln Ala Thr Asp Gly Leu Ala Gly Ala Leu Asp
385                 390                 395                 400 
Ala Arg Gln Gln Ser Thr Gly Ala
                405             


<210> 320
<211> 655
<212> PRT
<213> Homo sapiens

<400> 320
Met Gln Ala Ala Arg Met Ala Ala Ser Leu Gly Arg Gln Leu Leu Arg
 1               5                  10                  15      
Leu Gly Gly Gly Ser Ser Arg Leu Thr Ala Leu Leu Gly Gln Pro Arg
            20                  25                  30          
Pro Gly Pro Ala Arg Arg Pro Tyr Ala Gly Gly Ala Ala Gln Leu Ala
        35                  40                  45              
Leu Asp Lys Ser Asp Ser His Pro Ser Asp Ala Leu Thr Arg Lys Lys
    50                  55                  60                  
Pro Ala Lys Ala Glu Ser Lys Ser Phe Ala Val Gly Met Phe Lys Gly
65                  70                  75                  80  
Gln Leu Thr Thr Asp Gln Val Phe Pro Tyr Pro Ser Val Leu Asn Glu
                85                  90                  95      
Glu Gln Thr Gln Phe Leu Lys Glu Leu Val Glu Pro Val Ser Arg Phe
            100                 105                 110         
Phe Glu Glu Val Asn Asp Pro Ala Lys Asn Asp Ala Leu Glu Met Val
        115                 120                 125             
Glu Glu Thr Thr Trp Gln Gly Leu Lys Glu Leu Gly Ala Phe Gly Leu
    130                 135                 140                 
Gln Val Pro Ser Glu Leu Gly Gly Val Gly Leu Cys Asn Thr Gln Tyr
145                 150                 155                 160 
Ala Arg Leu Val Glu Ile Val Gly Met His Asp Leu Gly Val Gly Ile
                165                 170                 175     
Thr Leu Gly Ala His Gln Ser Ile Gly Phe Lys Gly Ile Leu Leu Phe
            180                 185                 190         
Cys Thr Lys Ala Gln Lys Glu Lys Tyr Leu Pro Lys Leu Ala Ser Gly
        195                 200                 205             
Glu Thr Val Ala Ala Phe Cys Leu Thr Glu Pro Ser Ser Gly Ser Asp
    210                 215                 220                 
Ala Ala Ser Ile Arg Thr Ser Ala Val Pro Ser Pro Cys Gly Lys Tyr
225                 230                 235                 240 
Tyr Thr Leu Asn Gly Ser Lys Leu Trp Ile Ser Asn Gly Gly Leu Ala
                245                 250                 255     
Asp Ile Phe Thr Val Phe Ala Lys Thr Pro Val Thr Asp Pro Ala Thr
            260                 265                 270         
Gly Ala Val Lys Glu Lys Ile Thr Ala Phe Val Val Glu Arg Gly Phe
        275                 280                 285             
Gly Gly Ile Thr His Gly Pro Pro Glu Lys Lys Met Gly Ile Lys Ala
    290                 295                 300                 
Ser Asn Thr Ala Glu Val Phe Phe Asp Gly Val Arg Val Pro Ser Glu
305                 310                 315                 320 
Asn Val Leu Gly Glu Val Gly Ser Gly Phe Lys Val Ala Met His Ile
                325                 330                 335     
Leu Asn Asn Gly Arg Phe Gly Met Ala Ala Ala Leu Ala Gly Thr Met
            340                 345                 350         
Arg Gly Ile Ile Ala Lys Ala Val Asp His Ala Thr Asn Arg Thr Gln
        355                 360                 365             
Phe Gly Glu Lys Ile His Asn Phe Gly Leu Ile Gln Glu Lys Leu Ala
    370                 375                 380                 
Arg Met Val Met Leu Gln Tyr Val Thr Glu Ser Met Ala Tyr Met Val
385                 390                 395                 400 
Ser Ala Asn Met Asp Gln Gly Ala Thr Asp Phe Gln Ile Glu Ala Ala
                405                 410                 415     
Ile Ser Lys Ile Phe Gly Ser Glu Ala Ala Trp Lys Val Thr Asp Glu
            420                 425                 430         
Cys Ile Gln Ile Met Gly Gly Met Gly Phe Met Lys Glu Pro Gly Val
        435                 440                 445             
Glu Arg Val Leu Arg Asp Leu Arg Ile Phe Arg Ile Phe Glu Gly Thr
    450                 455                 460                 
Asn Asp Ile Leu Arg Leu Phe Val Ala Leu Gln Gly Cys Met Asp Lys
465                 470                 475                 480 
Gly Lys Glu Leu Ser Gly Leu Gly Ser Ala Leu Lys Asn Pro Phe Gly
                485                 490                 495     
Asn Ala Gly Leu Leu Leu Gly Glu Ala Gly Lys Gln Leu Arg Arg Arg
            500                 505                 510         
Ala Gly Leu Gly Ser Gly Leu Ser Leu Ser Gly Leu Val His Pro Glu
        515                 520                 525             
Leu Ser Arg Ser Gly Glu Leu Ala Val Arg Ala Leu Glu Gln Phe Ala
    530                 535                 540                 
Thr Val Val Glu Ala Lys Leu Ile Lys His Lys Lys Gly Ile Val Asn
545                 550                 555                 560 
Glu Gln Phe Leu Leu Gln Arg Leu Ala Asp Gly Ala Ile Asp Leu Tyr
                565                 570                 575     
Ala Met Val Val Val Leu Ser Arg Ala Ser Arg Ser Leu Ser Glu Gly
            580                 585                 590         
His Pro Thr Ala Gln His Glu Lys Met Leu Cys Asp Thr Trp Cys Ile
        595                 600                 605             
Glu Ala Ala Ala Arg Ile Arg Glu Gly Met Ala Ala Leu Gln Ser Asp
    610                 615                 620                 
Pro Trp Gln Gln Glu Leu Tyr Arg Asn Phe Lys Ser Ile Ser Lys Ala
625                 630                 635                 640 
Leu Val Glu Arg Gly Gly Val Val Thr Ser Asn Pro Leu Gly Phe
                645                 650                 655 


<210> 321
<211> 107
<212> PRT
<213> Homo sapiens

<400> 321
Ala Val Pro Pro Thr Tyr Ala Asp Leu Gly Lys Ser Ala Arg Asp Val
 1               5                  10                  15      
Phe Thr Lys Gly Tyr Gly Phe Gly Leu Ile Lys Leu Asp Leu Lys Thr
            20                  25                  30          
Lys Ser Glu Asn Gly Leu Glu Phe Thr Ser Ser Gly Ser Ala Asn Thr
        35                  40                  45              
Glu Thr Thr Lys Val Thr Gly Ser Leu Glu Thr Lys Tyr Arg Trp Thr
    50                  55                  60                  
Glu Tyr Gly Leu Thr Phe Thr Glu Lys Trp Asn Thr Asp Asn Thr Leu
65                  70                  75                  80  
Gly Thr Glu Ile Thr Val Glu Asp Gln Leu Ala Arg Gly Leu Lys Leu
                85                  90                  95      
Thr Phe Asp Ser Ser Phe Ser Pro Asn Thr Gly
            100                 105         


<210> 322
<211> 1231
<212> PRT
<213> Homo sapiens

<400> 322
Asp Asp Ser Asp Gly Ile Pro Trp Ser Glu Glu Arg Val Val Arg Lys
 1               5                  10                  15      
Val Leu Tyr Leu Ser Leu Lys Glu Phe Lys Asn Ser Gln Lys Arg Gln
            20                  25                  30          
His Ala Glu Gly Ile Ala Gly Ser Leu Lys Thr Val Asn Gly Leu Leu
        35                  40                  45              
Gly Asn Asp Gln Ser Lys Gly Leu Gly Pro Ala Ser Glu Gln Ser Glu
    50                  55                  60                  
Asn Glu Lys Asp Asp Ala Ser Gln Val Ser Ser Thr Ser Asn Asp Val
65                  70                  75                  80  
Ser Ser Ser Asp Phe Glu Glu Gly Pro Ser Arg Lys Arg Pro Arg Leu
                85                  90                  95      
Gln Ala Gln Arg Lys Phe Ala Gln Ser Gln Pro Asn Ser Pro Ser Thr
            100                 105                 110         
Thr Pro Val Lys Ile Val Glu Pro Leu Leu Pro Pro Pro Ala Thr Gln
        115                 120                 125             
Ile Ser Asp Leu Ser Lys Arg Lys Pro Lys Thr Glu Asp Phe Leu Thr
    130                 135                 140                 
Phe Leu Cys Leu Arg Gly Ser Pro Ala Leu Pro Asn Ser Met Val Tyr
145                 150                 155                 160 
Phe Gly Ser Ser Gln Asp Glu Glu Glu Val Glu Glu Glu Asp Asp Glu
                165                 170                 175     
Thr Glu Asp Val Lys Thr Ala Thr Asn Asn Ala Ser Ser Ser Cys Gln
            180                 185                 190         
Ser Thr Pro Arg Lys Gly Lys Thr His Lys His Val His Asn Gly His
        195                 200                 205             
Val Phe Asn Gly Ser Ser Arg Ser Thr Arg Glu Lys Glu Pro Val Gln
    210                 215                 220                 
Lys His Lys Ser Lys Glu Ala Thr Pro Ala Lys Glu Lys His Ser Asp
225                 230                 235                 240 
His Arg Ala Asp Ser Arg Arg Glu Gln Ala Ser Ala Asn His Pro Ala
                245                 250                 255     
Ala Ala Pro Ser Thr Gly Ser Ser Ala Lys Gly Leu Ala Ala Thr His
            260                 265                 270         
His His Pro Pro Leu His Arg Ser Ala Gln Asp Leu Arg Lys Gln Val
        275                 280                 285             
Ser Lys Val Asn Gly Val Thr Arg Met Ser Ser Leu Gly Ala Gly Val
    290                 295                 300                 
Thr Ser Ala Lys Lys Met Arg Glu Val Arg Pro Ser Pro Ser Lys Thr
305                 310                 315                 320 
Val Lys Tyr Thr Ala Thr Val Thr Lys Gly Ala Val Thr Tyr Thr Lys
                325                 330                 335     
Ala Lys Arg Glu Leu Val Lys Asp Thr Lys Pro Asn His His Lys Pro
            340                 345                 350         
Ser Ser Ala Val Asn His Thr Ile Ser Gly Lys Thr Glu Ser Ser Asn
        355                 360                 365             
Ala Lys Thr Arg Lys Gln Val Leu Ser Leu Gly Gly Ala Ser Lys Ser
    370                 375                 380                 
Thr Gly Pro Ala Val Asn Gly Leu Lys Val Ser Gly Arg Leu Asn Pro
385                 390                 395                 400 
Lys Ser Cys Thr Lys Glu Val Gly Gly Arg Gln Leu Arg Glu Gly Leu
                405                 410                 415     
Gln Leu Arg Glu Gly Leu Arg Asn Ser Lys Arg Arg Leu Glu Glu Ala
            420                 425                 430         
His Gln Ala Glu Lys Pro Gln Ser Pro Pro Lys Lys Met Lys Gly Ala
        435                 440                 445             
Ala Gly Pro Ala Glu Gly Pro Gly Lys Lys Ala Pro Ala Glu Arg Gly
    450                 455                 460                 
Leu Leu Asn Gly His Val Lys Lys Glu Val Pro Glu Arg Ser Leu Glu
465                 470                 475                 480 
Arg Asn Arg Pro Lys Arg Ala Thr Ala Gly Lys Ser Thr Pro Gly Arg
                485                 490                 495     
Gln Ala His Gly Lys Ala Asp Ser Ala Ser Cys Glu Asn Arg Ser Thr
            500                 505                 510         
Ser Gln Pro Glu Ser Val His Lys Pro Gln Asp Ser Gly Lys Ala Glu
        515                 520                 525             
Lys Gly Gly Gly Lys Ala Gly Trp Ala Ala Met Asp Glu Ile Pro Val
    530                 535                 540                 
Leu Arg Pro Ser Ala Lys Glu Phe His Asp Pro Leu Ile Tyr Ile Glu
545                 550                 555                 560 
Ser Val Arg Ala Gln Val Glu Lys Phe Gly Met Cys Arg Val Ile Pro
                565                 570                 575     
Pro Pro Asp Trp Arg Pro Glu Cys Lys Leu Asn Asp Glu Met Arg Phe
            580                 585                 590         
Val Thr Gln Ile Gln His Ile His Lys Leu Gly Arg Arg Trp Gly Pro
        595                 600                 605             
Asn Val Gln Arg Leu Ala Cys Ile Lys Lys His Leu Lys Ser Gln Gly
    610                 615                 620                 
Ile Thr Met Asp Glu Leu Pro Leu Ile Gly Gly Cys Glu Leu Asp Leu
625                 630                 635                 640 
Ala Cys Phe Phe Arg Leu Ile Asn Glu Met Gly Gly Met Gln Gln Val
                645                 650                 655     
Thr Asp Leu Lys Lys Trp Asn Lys Leu Ala Asp Met Leu Arg Ile Pro
            660                 665                 670         
Arg Thr Ala Gln Asp Arg Leu Ala Lys Leu Gln Glu Ala Tyr Cys Gln
        675                 680                 685             
Tyr Leu Leu Ser Tyr Asp Ser Leu Ser Pro Glu Glu His Arg Arg Leu
    690                 695                 700                 
Glu Lys Glu Val Leu Met Glu Lys Glu Ile Leu Glu Lys Arg Lys Gly
705                 710                 715                 720 
Pro Leu Glu Gly His Thr Glu Asn Asp His His Lys Phe His Pro Leu
                725                 730                 735     
Pro Arg Phe Glu Pro Lys Asn Gly Leu Ile His Gly Val Ala Pro Arg
            740                 745                 750         
Asn Gly Phe Arg Ser Lys Leu Lys Glu Val Gly Gln Ala Gln Leu Lys
        755                 760                 765             
Thr Gly Arg Arg Arg Leu Phe Ala Gln Glu Lys Glu Val Val Lys Glu
    770                 775                 780                 
Glu Glu Glu Asp Lys Gly Val Leu Asn Asp Phe His Lys Cys Ile Tyr
785                 790                 795                 800 
Lys Gly Arg Ser Val Ser Leu Thr Thr Phe Tyr Arg Thr Ala Arg Asn
                805                 810                 815     
Ile Met Ser Met Cys Phe Ser Lys Glu Pro Ala Pro Ala Glu Ile Glu
            820                 825                 830         
Gln Glu Tyr Trp Arg Leu Val Glu Glu Lys Asp Cys His Val Ala Val
        835                 840                 845             
His Cys Gly Lys Val Asp Thr Asn Thr His Gly Ser Gly Phe Pro Val
    850                 855                 860                 
Gly Lys Ser Glu Pro Phe Ser Arg His Gly Trp Asn Leu Thr Val Leu
865                 870                 875                 880 
Pro Asn Asn Thr Gly Ser Ile Leu Arg His Leu Gly Ala Val Pro Gly
                885                 890                 895     
Val Thr Ile Pro Trp Leu Asn Ile Gly Met Val Phe Ser Thr Ser Cys
            900                 905                 910         
Trp Ser Arg Asp Gln Asn His Leu Pro Tyr Ile Asp Tyr Leu His Thr
        915                 920                 925             
Gly Ala Asp Cys Ile Trp Tyr Cys Ile Pro Ala Glu Glu Glu Asn Lys
    930                 935                 940                 
Leu Glu Asp Val Val His Thr Leu Leu Gln Ala Asn Gly Thr Pro Gly
945                 950                 955                 960 
Leu Gln Met Leu Glu Ser Asn Val Met Ile Ser Pro Glu Val Leu Cys
                965                 970                 975     
Lys Glu Gly Ile Lys Val His Arg Thr Val Gln Gln Ser Gly Gln Phe
            980                 985                 990         
Val Val Cys Phe Pro Gly Ser Phe Val Ser Lys Val Cys Cys Gly Tyr
        995                 1000                1005            
Ser Val Ser Glu Thr Val His Phe Ala Thr Thr Gln Trp Thr Ser Met
    1010                1015                1020                
Gly Phe Glu Thr Ala Lys Glu Met Lys Arg Arg His Ile Ala Lys Pro
1025                1030                1035                1040
Phe Ser Met Glu Lys Leu Leu Tyr Gln Ile Ala Gln Ala Glu Ala Lys
                1045                1050                1055    
Lys Glu Asn Gly Pro Thr Leu Ser Thr Ile Ser Ala Leu Leu Asp Glu
            1060                1065                1070        
Leu Arg Asp Thr Glu Leu Arg Gln Arg Arg Gln Leu Phe Glu Ala Gly
        1075                1080                1085            
Leu His Ser Ser Ala Arg Tyr Gly Ser His Asp Gly Ser Ser Thr Val
    1090                1095                1100                
Ala Asp Gly Lys Lys Lys Pro Arg Lys Trp Leu Gln Leu Glu Thr Ser
1105                1110                1115                1120
Glu Arg Arg Cys Gln Ile Cys Gln His Leu Cys Tyr Leu Ser Met Val
                1125                1130                1135    
Val Gln Glu Asn Glu Asn Val Val Phe Cys Leu Glu Cys Ala Leu Arg
            1140                1145                1150        
His Val Glu Lys Gln Lys Ser Cys Arg Gly Leu Lys Leu Met Tyr Arg
        1155                1160                1165            
Tyr Asp Glu Glu Gln Ile Ile Ser Leu Val Asn Gln Ile Cys Gly Lys
    1170                1175                1180                
Val Ser Gly Lys Asn Gly Ser Ile Glu Asn Cys Leu Ser Lys Pro Thr
1185                1190                1195                1200
Pro Lys Arg Gly Pro Arg Lys Arg Ala Thr Val Asp Val Pro Pro Ser
                1205                1210                1215    
Arg Leu Ser Ala Ser Ser Ser Ser Lys Ser Ala Ser Ser Ser Ser
            1220                1225                1230    


<210> 323
<211> 560
<212> PRT
<213> Homo sapiens

<400> 323
Val Pro Met Val Val Val Pro Pro Val Gly Ala Lys Gly Asn Thr Pro
 1               5                  10                  15      
Ala Thr Gly Thr Thr Gln Gly Lys Lys Ala Glu Gly Thr Gln Asn Gln
            20                  25                  30          
Ser Lys Lys Ala Glu Gly Ala Pro Asn Gln Gly Arg Lys Ala Glu Gly
        35                  40                  45              
Thr Pro Asn Gln Gly Lys Lys Thr Glu Gly Thr Pro Asn Gln Gly Lys
    50                  55                  60                  
Lys Ala Glu Gly Thr Pro Asn Gln Gly Lys Lys Ala Glu Gly Thr Pro
65                  70                  75                  80  
Asn Gln Gly Lys Lys Ala Glu Gly Ala Gln Asn Gln Gly Lys Lys Val
                85                  90                  95      
Asp Thr Thr Pro Asn Gln Gly Lys Lys Val Glu Gly Ala Pro Thr Gln
            100                 105                 110         
Gly Arg Lys Ala Glu Gly Ala Gln Asn Gln Ala Lys Lys Val Glu Gly
        115                 120                 125             
Ala Gln Asn Gln Gly Lys Lys Ala Glu Gly Ala Gln Asn Gln Gly Lys
    130                 135                 140                 
Lys Ala Glu Gly Ala Gln Asn Gln Gly Lys Lys Ala Glu Gly Ala Gln
145                 150                 155                 160 
Asn Gln Gly Lys Lys Ala Glu Gly Gly Gln Asn Gln Gly Lys Lys Thr
                165                 170                 175     
Glu Glu Ala Gln Lys Gln Gly Lys Lys Ala Glu Gly Ala Gln Ile Gln
            180                 185                 190         
Gly Lys Lys Asn Glu Gly Ala Gln Thr Gln Gly Lys Lys Ala Glu Gly
        195                 200                 205             
Ala Gln Asn Gln Gly Lys Lys Asn Glu Gly Ala Gln Thr Gln Gly Lys
    210                 215                 220                 
Lys Ala Glu Gly Ala Gln Thr Gln Gly Lys Lys Ala Asp Gly Ala Gln
225                 230                 235                 240 
Asn Gln Gly Lys Lys Ala Glu Gly Ala Gln Asn Gln Gly Lys Lys Ala
                245                 250                 255     
Glu Gly Ala Gln Asn Gln Gly Lys Lys Ala Glu Gly Ala Gln Asn Gln
            260                 265                 270         
Gly Lys Lys Ala Asp Gly Ala Gln Asn Gln Gly Lys Lys Ala Glu Gly
        275                 280                 285             
Ala Gln Asn Gln Gly Lys Lys Ala Glu Gly Ala Gln Asn Gln Gly Thr
    290                 295                 300                 
Lys Ala Glu Gly Ala Gln Asn Gln Gly Lys Lys Ala Glu Gly Ala Gln
305                 310                 315                 320 
Asn Gln Gly Lys Lys Ala Glu Gly Ala Gln Asn Gln Gly Lys Lys Ala
                325                 330                 335     
Glu Gly Ala Gln Asn Gln Gly Lys Lys Ala Glu Gly Ala Gln Asn Gln
            340                 345                 350         
Gly Lys Lys Ala Glu Gly Ala Gln Asn Gln Gly Lys Lys Ala Glu Gly
        355                 360                 365             
Ala Gln Asn Gln Gly Lys Lys Ala Glu Gly Ala Gln Asn Gln Gly Lys
    370                 375                 380                 
Lys Ala Glu Gly Ala Gln Asn Gln Gly Lys Lys Ala Glu Gly Ala Gln
385                 390                 395                 400 
Asn Gln Gly Lys Lys Ala Glu Gly Ala Gln Asn Gln Gly Lys Lys Ala
                405                 410                 415     
Glu Gly Ala Gln Asn Gln Gly Lys Lys Val Glu Gly Ala Gln Asn Gln
            420                 425                 430         
Gly Lys Lys Ala Glu Gly Ala Gln Asn Gln Gly Lys Lys Ala Glu Gly
        435                 440                 445             
Ala Gln Asn Gln Gly Lys Lys Ala Glu Gly Ala Gln Asn Gln Gly Gln
    450                 455                 460                 
Lys Gly Glu Gly Ala Gln Asn Gln Gly Lys Lys Thr Glu Gly Ala Gln
465                 470                 475                 480 
Gly Lys Lys Ala Glu Arg Ser Pro Asn Gln Gly Lys Lys Gly Glu Gly
                485                 490                 495     
Ala Pro Ile Gln Gly Lys Lys Ala Asp Ser Val Ala Asn Gln Gly Thr
            500                 505                 510         
Lys Val Glu Gly Ile Thr Asn Gln Gly Lys Lys Ala Glu Gly Ser Pro
        515                 520                 525             
Ser Glu Gly Lys Lys Ala Glu Gly Ser Pro Asn Gln Gly Lys Lys Ala
    530                 535                 540                 
Asp Ala Ala Ala Asn Gln Gly Lys Lys Thr Glu Ser Ala Ser Val Gln
545                 550                 555                 560 


<210> 324
<211> 734
<212> PRT
<213> Homo sapiens

<400> 324
Ala Ala Ala Asp Ser Thr Ser Met Ser Tyr Ser Val Thr Leu Thr Gly
 1               5                  10                  15      
Pro Gly Pro Trp Gly Phe Arg Leu Gln Gly Gly Lys Asp Phe Asn Met
            20                  25                  30          
Pro Leu Thr Ile Ser Arg Ile Thr Pro Gly Ser Lys Ala Ala Gln Ser
        35                  40                  45              
Gln Leu Ser Gln Gly Asp Leu Val Val Ala Ile Asp Gly Val Asn Thr
    50                  55                  60                  
Asp Thr Met Thr His Leu Glu Ala Gln Asn Lys Ile Lys Ser Ala Ser
65                  70                  75                  80  
Tyr Asn Leu Ser Leu Thr Leu Gln Lys Ser Lys Arg Pro Ile Pro Ile
                85                  90                  95      
Ser Thr Thr Ala Pro Pro Val Gln Thr Pro Leu Pro Val Ile Pro His
            100                 105                 110         
Gln Lys Asp Pro Ala Leu Asp Thr Asn Gly Ser Leu Val Ala Pro Ser
        115                 120                 125             
Pro Ser Pro Glu Ala Arg Ala Ser Pro Gly Thr Pro Gly Thr Pro Glu
    130                 135                 140                 
Leu Arg Pro Thr Phe Ser Pro Ala Phe Ser Arg Pro Ser Ala Phe Ser
145                 150                 155                 160 
Ser Leu Ala Glu Ala Ser Asp Pro Gly Pro Pro Arg Ala Ser Leu Arg
                165                 170                 175     
Ala Lys Thr Ser Pro Glu Gly Ala Arg Asp Leu Leu Gly Pro Lys Ala
            180                 185                 190         
Leu Pro Gly Ser Ser Gln Pro Arg Gln Tyr Asn Asn Pro Ile Gly Leu
        195                 200                 205             
Tyr Ser Ala Glu Thr Leu Arg Glu Met Ala Gln Met Tyr Gln Met Ser
    210                 215                 220                 
Leu Arg Gly Lys Ala Ser Gly Val Gly Leu Pro Gly Gly Ser Leu Pro
225                 230                 235                 240 
Ile Lys Asp Leu Ala Val Asp Ser Ala Ser Pro Val Tyr Gln Ala Val
                245                 250                 255     
Ile Lys Ser Gln Asn Lys Pro Glu Asp Glu Ala Asp Glu Trp Ala Arg
            260                 265                 270         
Arg Ser Ser Asn Leu Gln Ser Arg Ser Phe Arg Ile Leu Ala Gln Met
        275                 280                 285             
Thr Gly Thr Glu Phe Met Gln Asp Pro Asp Glu Glu Ala Leu Arg Arg
    290                 295                 300                 
Ser Ser Thr Pro Ile Glu His Ala Pro Val Cys Thr Ser Gln Ala Thr
305                 310                 315                 320 
Thr Pro Leu Leu Pro Ala Ser Ala Gln Pro Pro Ala Ala Ala Ser Pro
                325                 330                 335     
Ser Ala Ala Ser Pro Pro Leu Ala Thr Ala Ala Ala His Thr Ala Ile
            340                 345                 350         
Ala Ser Ala Ser Thr Thr Ala Pro Ala Ser Ser Pro Ala Asp Ser Pro
        355                 360                 365             
Arg Pro Gln Ala Ser Ser Tyr Ser Pro Ala Val Ala Ala Ser Ser Ala
    370                 375                 380                 
Pro Ala Thr His Thr Ser Tyr Ser Glu Gly Pro Ala Ala Pro Ala Pro
385                 390                 395                 400 
Lys Pro Arg Val Val Thr Thr Ala Ser Ile Arg Pro Ser Val Tyr Gln
                405                 410                 415     
Pro Val Pro Ala Ser Thr Tyr Ser Pro Ser Pro Gly Ala Asn Tyr Ser
            420                 425                 430         
Pro Thr Pro Tyr Thr Pro Ser Pro Ala Pro Ala Tyr Thr Pro Ser Pro
        435                 440                 445             
Ala Pro Ala Tyr Thr Pro Ser Pro Val Pro Thr Tyr Thr Pro Ser Pro
    450                 455                 460                 
Ala Pro Ala Tyr Thr Pro Ser Pro Ala Pro Asn Tyr Asn Pro Ala Pro
465                 470                 475                 480 
Ser Val Ala Tyr Ser Gly Gly Pro Ala Glu Pro Ala Ser Arg Pro Pro
                485                 490                 495     
Trp Val Thr Asp Asp Ser Phe Ser Gln Lys Phe Ala Pro Gly Lys Ser
            500                 505                 510         
Thr Thr Ser Ile Ser Lys Gln Thr Leu Pro Arg Gly Gly Pro Ala Tyr
        515                 520                 525             
Thr Pro Ala Gly Pro Gln Val Pro Pro Leu Ala Arg Gly Thr Val Gln
    530                 535                 540                 
Arg Ala Glu Arg Phe Pro Ala Ser Ser Arg Thr Pro Leu Cys Gly His
545                 550                 555                 560 
Cys Asn Asn Val Ile Arg Gly Pro Phe Leu Val Ala Met Gly Arg Ser
                565                 570                 575     
Trp His Pro Glu Glu Phe Thr Cys Ala Tyr Cys Lys Thr Ser Leu Ala
            580                 585                 590         
Asp Val Cys Phe Val Glu Glu Gln Asn Asn Val Tyr Cys Glu Arg Cys
        595                 600                 605             
Tyr Glu Gln Phe Phe Ala Pro Leu Cys Ala Lys Cys Asn Thr Lys Ile
    610                 615                 620                 
Met Gly Glu Val Met His Ala Leu Arg Gln Thr Trp His Thr Thr Cys
625                 630                 635                 640 
Phe Val Cys Ala Ala Cys Lys Lys Pro Phe Gly Asn Ser Leu Phe His
                645                 650                 655     
Met Glu Asp Gly Glu Pro Tyr Cys Glu Lys Asp Tyr Ile Asn Leu Phe
            660                 665                 670         
Ser Thr Lys Cys His Gly Cys Asp Phe Pro Val Glu Ala Gly Asp Lys
        675                 680                 685             
Phe Ile Glu Ala Leu Gly His Thr Trp His Asp Thr Cys Phe Ile Cys
    690                 695                 700                 
Ala Val Cys His Val Asn Leu Glu Gly Gln Pro Phe Tyr Ser Lys Lys
705                 710                 715                 720 
Asp Arg Pro Leu Cys Lys Lys His Ala His Thr Ile Asn Leu
                725                 730                 


<210> 325
<211> 1985
<212> PRT
<213> Homo sapiens

<400> 325
Pro Gly Cys Ala Ala Arg Leu Ser Arg Ala Arg Ala Pro Gly Pro Gly
 1               5                  10                  15      
Ala Ala Gly Ala Gly Arg Lys Arg Leu Ala Asp Pro Gly Pro Pro Pro
            20                  25                  30          
Ala Ser Arg Arg Leu Arg Ala Pro Gly Ser Arg Pro Arg Leu Ala Pro
        35                  40                  45              
Cys Thr Arg Arg Ala Ala Gln Pro Ala His Ala Arg Met Ala Pro Arg
    50                  55                  60                  
Ala Ala Gly Gly Ala Pro Leu Ser Ala Arg Ala Ala Ala Ala Ser Pro
65                  70                  75                  80  
Pro Pro Phe Gln Thr Pro Pro Arg Cys Pro Val Pro Leu Leu Leu Leu
                85                  90                  95      
Leu Leu Leu Gly Ala Ala Arg Ala Gly Ala Leu Glu Ile Gln Arg Arg
            100                 105                 110         
Phe Pro Ser Pro Thr Pro Thr Asn Asn Phe Ala Leu Asp Gly Ala Ala
        115                 120                 125             
Gly Thr Val Tyr Leu Ala Ala Val Asn Arg Leu Tyr Gln Leu Ser Gly
    130                 135                 140                 
Ala Asn Leu Ser Leu Glu Ala Glu Ala Ala Val Gly Pro Val Pro Asp
145                 150                 155                 160 
Ser Pro Leu Cys His Ala Pro Gln Leu Pro Gln Ala Ser Cys Glu His
                165                 170                 175     
Pro Arg Arg Leu Thr Asp Asn Tyr Asn Lys Ile Leu Gln Leu Asp Pro
            180                 185                 190         
Gly Gln Gly Leu Val Val Val Cys Gly Ser Ile Tyr Gln Gly Phe Cys
        195                 200                 205             
Gln Leu Arg Arg Arg Gly Asn Ile Ser Ala Val Ala Val Arg Phe Pro
    210                 215                 220                 
Pro Ala Ala Pro Pro Ala Glu Pro Val Thr Val Phe Pro Ser Met Leu
225                 230                 235                 240 
Asn Val Ala Ala Asn His Pro Asn Ala Ser Thr Val Gly Leu Val Leu
                245                 250                 255     
Pro Pro Ala Ala Gly Ala Gly Gly Ser Arg Leu Leu Val Gly Ala Thr
            260                 265                 270         
Tyr Thr Gly Tyr Gly Ser Ser Phe Phe Pro Arg Asn Arg Ser Leu Glu
        275                 280                 285             
Asp His Arg Phe Glu Asn Thr Pro Glu Ile Ala Ile Arg Ser Leu Asp
    290                 295                 300                 
Thr Arg Gly Asp Leu Ala Lys Leu Phe Thr Phe Asp Leu Asn Pro Ser
305                 310                 315                 320 
Asp Asp Asn Ile Leu Lys Ile Lys Gln Gly Ala Lys Glu Gln His Lys
                325                 330                 335     
Leu Gly Phe Val Ser Ala Phe Leu His Pro Ser Asp Pro Pro Pro Gly
            340                 345                 350         
Ala Gln Ser Tyr Ala Tyr Leu Ala Leu Asn Ser Glu Ala Arg Ala Gly
        355                 360                 365             
Asp Lys Glu Ser Gln Ala Arg Ser Leu Leu Ala Arg Ile Cys Leu Pro
    370                 375                 380                 
His Gly Ala Gly Gly Asp Ala Lys Lys Leu Thr Glu Ser Tyr Ile Gln
385                 390                 395                 400 
Leu Gly Leu Gln Cys Ala Gly Gly Ala Gly Arg Gly Asp Leu Tyr Ser
                405                 410                 415     
Arg Leu Val Ser Val Phe Pro Ala Arg Glu Arg Leu Phe Ala Val Phe
            420                 425                 430         
Glu Arg Pro Gln Gly Ser Pro Ala Ala Arg Ala Ala Pro Ala Ala Leu
        435                 440                 445             
Cys Ala Phe Arg Phe Ala Asp Val Arg Ala Ala Ile Arg Ala Ala Arg
    450                 455                 460                 
Thr Ala Cys Phe Val Glu Pro Ala Pro Asp Val Val Ala Val Leu Asp
465                 470                 475                 480 
Ser Val Val Gln Gly Thr Gly Pro Ala Cys Glu Arg Lys Leu Asn Ile
                485                 490                 495     
Gln Leu Gln Pro Glu Gln Leu Asp Cys Gly Ala Ala His Leu Gln His
            500                 505                 510         
Pro Leu Ser Ile Leu Gln Pro Leu Lys Ala Thr Pro Val Phe Arg Ala
        515                 520                 525             
Pro Gly Leu Thr Ser Val Ala Val Ala Ser Val Asn Asn Tyr Thr Ala
    530                 535                 540                 
Val Phe Leu Gly Thr Val Asn Gly Arg Leu Leu Lys Ile Asn Leu Asn
545                 550                 555                 560 
Glu Ser Met Gln Val Val Ser Arg Arg Val Val Thr Val Ala Tyr Gly
                565                 570                 575     
Glu Pro Val His His Val Met Gln Phe Asp Pro Ala Asp Ser Val Tyr
            580                 585                 590         
Leu Tyr Leu Met Thr Ser His Gln Met Ala Arg Val Lys Val Ala Ala
        595                 600                 605             
Cys Asn Val His Ser Thr Cys Gly Asp Cys Val Gly Ala Ala Asp Ala
    610                 615                 620                 
Tyr Cys Gly Trp Cys Ala Leu Glu Thr Arg Cys Thr Leu Gln Gln Asp
625                 630                 635                 640 
Cys Thr Asn Ser Ser Gln Gln His Phe Trp Thr Ser Ala Ser Glu Gly
                645                 650                 655     
Pro Ser Arg Cys Pro Ala Met Thr Val Leu Pro Ser Glu Ile Asp Val
            660                 665                 670         
Arg Gln Glu Tyr Pro Gly Met Ile Leu Gln Ile Ser Gly Ser Leu Pro
        675                 680                 685             
Ser Leu Ser Gly Met Glu Met Ala Cys Asp Tyr Gly Asn Asn Ile Arg
    690                 695                 700                 
Thr Val Ala Arg Val Pro Gly Pro Ala Phe Gly His Gln Ile Ala Tyr
705                 710                 715                 720 
Cys Asn Leu Leu Pro Arg Asp Gln Phe Pro Pro Phe Pro Pro Asn Gln
                725                 730                 735     
Asp His Val Thr Val Glu Met Ser Val Arg Val Asn Gly Arg Asn Ile
            740                 745                 750         
Val Lys Ala Asn Phe Thr Ile Tyr Asp Cys Ser Arg Thr Ala Gln Val
        755                 760                 765             
Tyr Pro His Thr Ala Cys Thr Ser Cys Leu Ser Ala Gln Trp Pro Cys
    770                 775                 780                 
Phe Trp Cys Ser Gln Gln His Ser Cys Val Ser Asn Gln Ser Arg Cys
785                 790                 795                 800 
Glu Ala Ser Pro Asn Pro Thr Ser Pro Gln Asp Cys Pro Arg Thr Leu
                805                 810                 815     
Leu Ser Pro Leu Ala Pro Val Pro Thr Gly Gly Ser Gln Asn Ile Leu
            820                 825                 830         
Val Pro Leu Ala Asn Thr Ala Phe Phe Gln Gly Ala Ala Leu Glu Cys
        835                 840                 845             
Ser Phe Gly Leu Glu Glu Ile Phe Glu Ala Val Trp Val Asn Glu Ser
    850                 855                 860                 
Val Val Arg Cys Asp Gln Val Val Leu His Thr Thr Arg Lys Ser Gln
865                 870                 875                 880 
Val Phe Pro Leu Ser Leu Gln Leu Lys Gly Arg Pro Ala Arg Phe Leu
                885                 890                 895     
Asp Ser Pro Glu Pro Met Thr Val Met Val Tyr Asn Cys Ala Met Gly
            900                 905                 910         
Ser Pro Asp Cys Ser Gln Cys Leu Gly Arg Glu Asp Leu Gly His Leu
        915                 920                 925             
Cys Met Trp Ser Asp Gly Cys Arg Leu Arg Gly Pro Leu Gln Pro Met
    930                 935                 940                 
Ala Gly Thr Cys Pro Ala Pro Glu Ile Arg Ala Ile Glu Pro Leu Ser
945                 950                 955                 960 
Gly Pro Leu Asp Gly Gly Thr Leu Leu Thr Ile Arg Gly Arg Asn Leu
                965                 970                 975     
Gly Arg Arg Leu Ser Asp Val Ala His Gly Val Trp Ile Gly Gly Val
            980                 985                 990         
Ala Cys Glu Pro Leu Pro Asp Arg Tyr Thr Val Ser Glu Glu Ile Val
        995                 1000                1005            
Cys Val Thr Gly Pro Ala Pro Gly Pro Leu Ser Gly Val Val Thr Val
    1010                1015                1020                
Asn Ala Ser Lys Glu Gly Lys Ser Arg Asp Arg Phe Ser Tyr Val Leu
1025                1030                1035                1040
Pro Leu Val His Ser Leu Glu Pro Thr Met Gly Pro Lys Ala Gly Gly
                1045                1050                1055    
Thr Arg Ile Thr Ile His Gly Asn Asp Leu His Val Gly Ser Glu Leu
            1060                1065                1070        
Gln Val Leu Val Asn Asp Thr Asp Pro Cys Thr Glu Leu Met Arg Thr
        1075                1080                1085            
Asp Thr Ser Ile Ala Cys Thr Met Pro Glu Gly Ala Leu Pro Ala Pro
    1090                1095                1100                
Val Pro Val Cys Val Arg Phe Glu Arg Arg Gly Cys Val His Gly Asn
1105                1110                1115                1120
Leu Thr Phe Trp Tyr Met Gln Asn Pro Val Ile Thr Ala Ile Ser Pro
                1125                1130                1135    
Arg Arg Ser Pro Val Ser Gly Gly Arg Thr Ile Thr Val Ala Gly Glu
            1140                1145                1150        
Arg Phe His Met Val Gln Asn Val Ser Met Ala Val His His Ile Gly
        1155                1160                1165            
Arg Glu Pro Thr Leu Cys Lys Val Leu Asn Ser Thr Leu Ile Thr Cys
    1170                1175                1180                
Pro Ser Pro Gly Ala Leu Ser Asn Ala Ser Ala Pro Val Asp Phe Phe
1185                1190                1195                1200
Ile Asn Gly Arg Ala Tyr Ala Asp Glu Val Ala Val Ala Glu Glu Leu
                1205                1210                1215    
Leu Asp Pro Glu Glu Ala Gln Arg Gly Ser Arg Phe Arg Leu Asp Tyr
            1220                1225                1230        
Leu Pro Asn Pro Gln Phe Ser Thr Ala Lys Arg Glu Lys Trp Ile Lys
        1235                1240                1245            
His His Pro Gly Glu Pro Leu Thr Leu Val Ile His Lys Glu Gln Asp
    1250                1255                1260                
Ser Leu Gly Leu Gln Ser His Glu Tyr Arg Val Lys Ile Gly Gln Val
1265                1270                1275                1280
Ser Cys Asp Ile Gln Ile Val Ser Asp Arg Ile Ile His Cys Ser Val
                1285                1290                1295    
Asn Glu Ser Leu Gly Ala Ala Val Gly Gln Leu Pro Ile Thr Ile Gln
            1300                1305                1310        
Val Gly Asn Phe Asn Gln Thr Ile Ala Thr Leu Gln Leu Gly Gly Ser
        1315                1320                1325            
Glu Thr Ala Ile Ile Val Ser Ile Val Ile Cys Ser Val Leu Leu Leu
    1330                1335                1340                
Leu Ser Val Val Ala Leu Phe Val Phe Cys Thr Lys Ser Arg Arg Ala
1345                1350                1355                1360
Glu Arg Tyr Trp Gln Lys Thr Leu Leu Gln Met Glu Glu Met Glu Ser
                1365                1370                1375    
Gln Ile Arg Glu Glu Ile Arg Lys Gly Phe Ala Glu Leu Gln Thr Asp
            1380                1385                1390        
Met Thr Asp Leu Thr Lys Glu Leu Asn Arg Ser Gln Gly Ile Pro Phe
        1395                1400                1405            
Leu Glu Tyr Lys His Phe Val Thr Arg Thr Phe Phe Pro Lys Cys Ser
    1410                1415                1420                
Ser Leu Tyr Glu Glu Arg Tyr Val Leu Pro Ser Gln Thr Leu Asn Ser
1425                1430                1435                1440
Gln Gly Ser Ser Gln Ala Gln Glu Thr His Pro Leu Leu Gly Glu Trp
                1445                1450                1455    
Lys Ile Pro Glu Ser Cys Arg Pro Asn Met Glu Glu Gly Ile Ser Leu
            1460                1465                1470        
Phe Ser Ser Leu Leu Asn Asn Lys His Phe Leu Ile Val Phe Val His
        1475                1480                1485            
Ala Leu Glu Gln Gln Lys Asp Phe Ala Val Arg Asp Arg Cys Ser Leu
    1490                1495                1500                
Ala Ser Leu Leu Thr Ile Ala Leu His Gly Lys Leu Glu Tyr Tyr Thr
1505                1510                1515                1520
Ser Ile Met Lys Glu Leu Leu Val Asp Leu Ile Asp Ala Ser Ala Ala
                1525                1530                1535    
Lys Asn Pro Lys Leu Met Leu Arg Arg Thr Glu Ser Val Val Glu Lys
            1540                1545                1550        
Met Leu Thr Asn Trp Met Ser Ile Cys Met Tyr Ser Cys Leu Arg Glu
        1555                1560                1565            
Thr Val Gly Glu Pro Phe Phe Leu Leu Leu Cys Ala Ile Lys Gln Gln
    1570                1575                1580                
Ile Asn Lys Gly Ser Ile Asp Ala Ile Thr Gly Lys Ala Arg Tyr Thr
1585                1590                1595                1600
Leu Asn Glu Glu Trp Leu Leu Arg Glu Asn Ile Glu Ala Lys Pro Arg
                1605                1610                1615    
Asn Leu Asn Val Ser Phe Gln Gly Cys Gly Met Asp Ser Leu Ser Val
            1620                1625                1630        
Arg Ala Met Asp Thr Asp Thr Leu Thr Gln Val Lys Glu Lys Ile Leu
        1635                1640                1645            
Glu Ala Phe Cys Lys Asn Val Pro Tyr Ser Gln Trp Pro Arg Ala Glu
    1650                1655                1660                
Asp Val Asp Leu Glu Trp Phe Ala Ser Ser Thr Gln Ser Tyr Ile Leu
1665                1670                1675                1680
Arg Asp Leu Asp Asp Thr Ser Val Val Glu Asp Gly Arg Lys Lys Leu
                1685                1690                1695    
Asn Thr Leu Ala His Tyr Lys Ile Pro Glu Gly Ala Ser Leu Ala Met
            1700                1705                1710        
Ser Leu Ile Asp Lys Lys Asp Asn Thr Leu Gly Arg Val Lys Asp Leu
        1715                1720                1725            
Asp Thr Glu Lys Tyr Phe His Leu Val Leu Pro Thr Asp Glu Leu Ala
    1730                1735                1740                
Glu Pro Lys Lys Ser His Arg Gln Ser His Arg Lys Lys Val Leu Pro
1745                1750                1755                1760
Glu Ile Tyr Leu Thr Arg Leu Leu Ser Thr Lys Gly Thr Leu Gln Lys
                1765                1770                1775    
Phe Leu Asp Asp Leu Phe Lys Ala Ile Leu Ser Ile Arg Glu Asp Lys
            1780                1785                1790        
Pro Pro Leu Ala Val Lys Tyr Phe Phe Asp Phe Leu Glu Glu Gln Ala
        1795                1800                1805            
Glu Lys Arg Gly Ile Ser Asp Pro Asp Thr Leu His Ile Trp Lys Thr
    1810                1815                1820                
Asn Ser Leu Pro Leu Arg Phe Trp Val Asn Ile Leu Lys Asn Pro Gln
1825                1830                1835                1840
Phe Val Phe Asp Ile Asp Lys Thr Asp His Ile Asp Ala Cys Leu Ser
                1845                1850                1855    
Val Ile Ala Gln Ala Phe Ile Asp Ala Cys Ser Ile Ser Asp Leu Gln
            1860                1865                1870        
Leu Gly Lys Asp Ser Pro Thr Asn Lys Leu Leu Tyr Ala Lys Glu Ile
        1875                1880                1885            
Pro Glu Tyr Arg Lys Ile Val Gln Arg Tyr Tyr Lys Gln Ile Gln Asp
    1890                1895                1900                
Met Thr Pro Leu Ser Glu Gln Glu Met Asn Ala His Leu Ala Glu Glu
1905                1910                1915                1920
Ser Arg Lys Tyr Gln Asn Glu Phe Asn Thr Asn Val Ala Met Ala Glu
                1925                1930                1935    
Ile Tyr Lys Tyr Ala Lys Arg Tyr Arg Pro Gln Ile Met Ala Ala Leu
            1940                1945                1950        
Glu Ala Asn Pro Thr Ala Arg Arg Thr Gln Leu Gln His Lys Phe Glu
        1955                1960                1965            
Gln Val Val Ala Leu Met Glu Asp Asn Ile Tyr Glu Cys Tyr Ser Glu
    1970                1975                1980                
Ala
1985


<210> 326
<211> 1985
<212> PRT
<213> Homo sapiens

<400> 326
Pro Gly Cys Ala Ala Arg Leu Ser Arg Ala Arg Ala Pro Gly Pro Gly
 1               5                  10                  15      
Ala Ala Gly Ala Gly Arg Lys Arg Leu Ala Asp Pro Gly Pro Pro Pro
            20                  25                  30          
Ala Ser Arg Arg Leu Arg Ala Pro Gly Ser Arg Pro Arg Leu Ala Pro
        35                  40                  45              
Cys Thr Arg Arg Ala Ala Gln Pro Ala His Ala Arg Met Ala Pro Arg
    50                  55                  60                  
Ala Ala Gly Gly Ala Pro Leu Ser Ala Arg Ala Ala Ala Ala Ser Pro
65                  70                  75                  80  
Pro Pro Phe Gln Thr Pro Pro Arg Cys Pro Val Pro Leu Leu Leu Leu
                85                  90                  95      
Leu Leu Leu Gly Ala Ala Arg Ala Gly Ala Leu Glu Ile Gln Arg Arg
            100                 105                 110         
Phe Pro Ser Pro Thr Pro Thr Asn Asn Phe Ala Leu Asp Gly Ala Ala
        115                 120                 125             
Gly Thr Val Tyr Leu Ala Ala Val Asn Arg Leu Tyr Gln Leu Ser Gly
    130                 135                 140                 
Ala Asn Leu Ser Leu Glu Ala Glu Ala Ala Val Gly Pro Val Pro Asp
145                 150                 155                 160 
Ser Pro Leu Cys His Ala Pro Gln Leu Pro Gln Ala Ser Cys Glu His
                165                 170                 175     
Pro Arg Arg Leu Thr Asp Asn Tyr Asn Lys Ile Leu Gln Leu Asp Pro
            180                 185                 190         
Gly Gln Gly Leu Val Val Val Cys Gly Ser Ile Tyr Gln Gly Phe Cys
        195                 200                 205             
Gln Leu Arg Arg Arg Gly Asn Ile Ser Ala Val Ala Val Arg Phe Pro
    210                 215                 220                 
Pro Ala Ala Pro Pro Ala Glu Pro Val Thr Val Phe Pro Ser Met Leu
225                 230                 235                 240 
Asn Val Ala Ala Asn His Pro Asn Ala Ser Thr Val Gly Leu Val Leu
                245                 250                 255     
Pro Pro Ala Ala Gly Ala Gly Gly Ser Arg Leu Leu Val Gly Ala Thr
            260                 265                 270         
Tyr Thr Gly Tyr Gly Ser Ser Phe Phe Pro Arg Asn Arg Ser Leu Glu
        275                 280                 285             
Asp His Arg Phe Glu Asn Thr Pro Glu Ile Ala Ile Arg Ser Leu Asp
    290                 295                 300                 
Thr Arg Gly Asp Leu Ala Lys Leu Phe Thr Phe Asp Leu Asn Pro Ser
305                 310                 315                 320 
Asp Asp Asn Ile Leu Lys Ile Lys Gln Gly Ala Lys Glu Gln His Lys
                325                 330                 335     
Leu Gly Phe Val Ser Ala Phe Leu His Pro Ser Asp Pro Pro Pro Gly
            340                 345                 350         
Ala Gln Ser Tyr Ala Tyr Leu Ala Leu Asn Ser Glu Ala Arg Ala Gly
        355                 360                 365             
Asp Lys Glu Ser Gln Ala Arg Ser Leu Leu Ala Arg Ile Cys Leu Pro
    370                 375                 380                 
His Gly Ala Gly Gly Asp Ala Lys Lys Leu Thr Glu Ser Tyr Ile Gln
385                 390                 395                 400 
Leu Gly Leu Gln Cys Ala Gly Gly Ala Gly Arg Gly Asp Leu Tyr Ser
                405                 410                 415     
Arg Leu Val Ser Val Phe Pro Ala Arg Glu Arg Leu Phe Ala Val Phe
            420                 425                 430         
Glu Arg Pro Gln Gly Ser Pro Ala Ala Arg Ala Ala Pro Ala Ala Leu
        435                 440                 445             
Cys Ala Phe Arg Phe Ala Asp Val Arg Ala Ala Ile Arg Ala Ala Arg
    450                 455                 460                 
Thr Ala Cys Phe Val Glu Pro Ala Pro Asp Val Val Ala Val Leu Asp
465                 470                 475                 480 
Ser Val Val Gln Gly Thr Gly Pro Ala Cys Glu Arg Lys Leu Asn Ile
                485                 490                 495     
Gln Leu Gln Pro Glu Gln Leu Asp Cys Gly Ala Ala His Leu Gln His
            500                 505                 510         
Pro Leu Ser Ile Leu Gln Pro Leu Lys Ala Thr Pro Val Phe Arg Ala
        515                 520                 525             
Pro Gly Leu Thr Ser Val Ala Val Ala Ser Val Asn Asn Tyr Thr Ala
    530                 535                 540                 
Val Phe Leu Gly Thr Val Asn Gly Arg Leu Leu Lys Ile Asn Leu Asn
545                 550                 555                 560 
Glu Ser Met Gln Val Val Ser Arg Arg Val Val Thr Val Ala Tyr Gly
                565                 570                 575     
Glu Pro Val His His Val Met Gln Phe Asp Pro Ala Asp Ser Val Tyr
            580                 585                 590         
Leu Tyr Leu Met Thr Ser His Gln Met Ala Arg Val Lys Val Ala Ala
        595                 600                 605             
Cys Asn Val His Ser Thr Cys Gly Asp Cys Val Gly Ala Ala Asp Ala
    610                 615                 620                 
Tyr Cys Gly Trp Cys Ala Leu Glu Thr Arg Cys Thr Leu Gln Gln Asp
625                 630                 635                 640 
Cys Thr Asn Ser Ser Gln Gln His Phe Trp Thr Ser Ala Ser Glu Gly
                645                 650                 655     
Pro Ser Arg Cys Pro Ala Met Thr Val Leu Pro Ser Glu Ile Asp Val
            660                 665                 670         
Arg Gln Glu Tyr Pro Gly Met Ile Leu Gln Ile Ser Gly Ser Leu Pro
        675                 680                 685             
Ser Leu Ser Gly Met Glu Met Ala Cys Asp Tyr Gly Asn Asn Ile Arg
    690                 695                 700                 
Thr Val Ala Arg Val Pro Gly Pro Ala Phe Gly His Gln Ile Ala Tyr
705                 710                 715                 720 
Cys Asn Leu Leu Pro Arg Asp Gln Phe Pro Pro Phe Pro Pro Asn Gln
                725                 730                 735     
Asp His Val Thr Val Glu Met Ser Val Arg Val Asn Gly Arg Asn Ile
            740                 745                 750         
Val Lys Ala Asn Phe Thr Ile Tyr Asp Cys Ser Arg Thr Ala Gln Val
        755                 760                 765             
Tyr Pro His Thr Ala Cys Thr Ser Cys Leu Ser Ala Gln Trp Pro Cys
    770                 775                 780                 
Phe Trp Cys Ser Gln Gln His Ser Cys Val Ser Asn Gln Ser Arg Cys
785                 790                 795                 800 
Glu Ala Ser Pro Asn Pro Thr Ser Pro Gln Asp Cys Pro Arg Thr Leu
                805                 810                 815     
Leu Ser Pro Leu Ala Pro Val Pro Thr Gly Gly Ser Gln Asn Ile Leu
            820                 825                 830         
Val Pro Leu Ala Asn Thr Ala Phe Phe Gln Gly Ala Ala Leu Glu Cys
        835                 840                 845             
Ser Phe Gly Leu Glu Glu Ile Phe Glu Ala Val Trp Val Asn Glu Ser
    850                 855                 860                 
Val Val Arg Cys Asp Gln Val Val Leu His Thr Thr Arg Lys Ser Gln
865                 870                 875                 880 
Val Phe Pro Leu Ser Leu Gln Leu Lys Gly Arg Pro Ala Arg Phe Leu
                885                 890                 895     
Asp Ser Pro Glu Pro Met Thr Val Met Val Tyr Asn Cys Ala Met Gly
            900                 905                 910         
Ser Pro Asp Cys Ser Gln Cys Leu Gly Arg Glu Asp Leu Gly His Leu
        915                 920                 925             
Cys Met Trp Ser Asp Gly Cys Arg Leu Arg Gly Pro Leu Gln Pro Met
    930                 935                 940                 
Ala Gly Thr Cys Pro Ala Pro Glu Ile Arg Ala Ile Glu Pro Leu Ser
945                 950                 955                 960 
Gly Pro Leu Asp Gly Gly Thr Leu Leu Thr Ile Arg Gly Arg Asn Leu
                965                 970                 975     
Gly Arg Arg Leu Ser Asp Val Ala His Gly Val Trp Ile Gly Gly Val
            980                 985                 990         
Ala Cys Glu Pro Leu Pro Asp Arg Tyr Thr Val Ser Glu Glu Ile Val
        995                 1000                1005            
Cys Val Thr Gly Pro Ala Pro Gly Pro Leu Ser Gly Val Val Thr Val
    1010                1015                1020                
Asn Ala Ser Lys Glu Gly Lys Ser Arg Asp Arg Phe Ser Tyr Val Leu
1025                1030                1035                1040
Pro Leu Val His Ser Leu Glu Pro Thr Met Gly Pro Lys Ala Gly Gly
                1045                1050                1055    
Thr Arg Ile Thr Ile His Gly Asn Asp Leu His Val Gly Ser Glu Leu
            1060                1065                1070        
Gln Val Leu Val Asn Asp Thr Asp Pro Cys Thr Glu Leu Met Arg Thr
        1075                1080                1085            
Asp Thr Ser Ile Ala Cys Thr Met Pro Glu Gly Ala Leu Pro Ala Pro
    1090                1095                1100                
Val Pro Val Cys Val Arg Phe Glu Arg Arg Gly Cys Val His Gly Asn
1105                1110                1115                1120
Leu Thr Phe Trp Tyr Met Gln Asn Pro Val Ile Thr Ala Ile Ser Pro
                1125                1130                1135    
Arg Arg Ser Pro Val Ser Gly Gly Arg Thr Ile Thr Val Ala Gly Glu
            1140                1145                1150        
Arg Phe His Met Val Gln Asn Val Ser Met Ala Val His His Ile Gly
        1155                1160                1165            
Arg Glu Pro Thr Leu Cys Lys Val Leu Asn Ser Thr Leu Ile Thr Cys
    1170                1175                1180                
Pro Ser Pro Gly Ala Leu Ser Asn Ala Ser Ala Pro Val Asp Phe Phe
1185                1190                1195                1200
Ile Asn Gly Arg Ala Tyr Ala Asp Glu Val Ala Val Ala Glu Glu Leu
                1205                1210                1215    
Leu Asp Pro Glu Glu Ala Gln Arg Gly Ser Arg Phe Arg Leu Asp Tyr
            1220                1225                1230        
Leu Pro Asn Pro Gln Phe Ser Thr Ala Lys Arg Glu Lys Trp Ile Lys
        1235                1240                1245            
His His Pro Gly Glu Pro Leu Thr Leu Val Ile His Lys Glu Gln Asp
    1250                1255                1260                
Ser Leu Gly Leu Gln Ser His Glu Tyr Arg Val Lys Ile Gly Gln Val
1265                1270                1275                1280
Ser Cys Asp Ile Gln Ile Val Ser Asp Arg Ile Ile His Cys Ser Val
                1285                1290                1295    
Asn Glu Ser Leu Gly Ala Ala Val Gly Gln Leu Pro Ile Thr Ile Gln
            1300                1305                1310        
Val Gly Asn Phe Asn Gln Thr Ile Ala Thr Leu Gln Leu Gly Gly Ser
        1315                1320                1325            
Glu Thr Ala Ile Ile Val Ser Ile Val Ile Cys Ser Val Leu Leu Leu
    1330                1335                1340                
Leu Ser Val Val Ala Leu Phe Val Phe Cys Thr Lys Ser Arg Arg Ala
1345                1350                1355                1360
Glu Arg Tyr Trp Gln Lys Thr Leu Leu Gln Met Glu Glu Met Glu Ser
                1365                1370                1375    
Gln Ile Arg Glu Glu Ile Arg Lys Gly Phe Ala Glu Leu Gln Thr Asp
            1380                1385                1390        
Met Thr Asp Leu Thr Lys Glu Leu Asn Arg Ser Gln Gly Ile Pro Phe
        1395                1400                1405            
Leu Glu Tyr Lys His Phe Val Thr Arg Thr Phe Phe Pro Lys Cys Ser
    1410                1415                1420                
Ser Leu Tyr Glu Glu Arg Tyr Val Leu Pro Ser Gln Thr Leu Asn Ser
1425                1430                1435                1440
Gln Gly Ser Ser Gln Ala Gln Glu Thr His Pro Leu Leu Gly Glu Trp
                1445                1450                1455    
Lys Ile Pro Glu Ser Cys Arg Pro Asn Met Glu Glu Gly Ile Ser Leu
            1460                1465                1470        
Phe Ser Ser Leu Leu Asn Asn Lys His Phe Leu Ile Val Phe Val His
        1475                1480                1485            
Ala Leu Glu Gln Gln Lys Asp Phe Ala Val Arg Asp Arg Cys Ser Leu
    1490                1495                1500                
Ala Ser Leu Leu Thr Ile Ala Leu His Gly Lys Leu Glu Tyr Tyr Thr
1505                1510                1515                1520
Ser Ile Met Lys Glu Leu Leu Val Asp Leu Ile Asp Ala Ser Ala Ala
                1525                1530                1535    
Lys Asn Pro Lys Leu Met Leu Arg Arg Thr Glu Ser Val Val Glu Lys
            1540                1545                1550        
Met Leu Thr Asn Trp Met Ser Ile Cys Met Tyr Ser Cys Leu Arg Glu
        1555                1560                1565            
Thr Val Gly Glu Pro Phe Phe Leu Leu Leu Cys Ala Ile Lys Gln Gln
    1570                1575                1580                
Ile Asn Lys Gly Ser Ile Asp Ala Ile Thr Gly Lys Ala Arg Tyr Thr
1585                1590                1595                1600
Leu Asn Glu Glu Trp Leu Leu Arg Glu Asn Ile Glu Ala Lys Pro Arg
                1605                1610                1615    
Asn Leu Asn Val Ser Phe Gln Gly Cys Gly Met Asp Ser Leu Ser Val
            1620                1625                1630        
Arg Ala Met Asp Thr Asp Thr Leu Thr Gln Val Lys Glu Lys Ile Leu
        1635                1640                1645            
Glu Ala Phe Cys Lys Asn Val Pro Tyr Ser Gln Trp Pro Arg Ala Glu
    1650                1655                1660                
Asp Val Asp Leu Glu Trp Phe Ala Ser Ser Thr Gln Ser Tyr Ile Leu
1665                1670                1675                1680
Arg Asp Leu Asp Asp Thr Ser Val Val Glu Asp Gly Arg Lys Lys Leu
                1685                1690                1695    
Asn Thr Leu Ala His Tyr Lys Ile Pro Glu Gly Ala Ser Leu Ala Met
            1700                1705                1710        
Ser Leu Ile Asp Lys Lys Asp Asn Thr Leu Gly Arg Val Lys Asp Leu
        1715                1720                1725            
Asp Thr Glu Lys Tyr Phe His Leu Val Leu Pro Thr Asp Glu Leu Ala
    1730                1735                1740                
Glu Pro Lys Lys Ser His Arg Gln Ser His Arg Lys Lys Val Leu Pro
1745                1750                1755                1760
Glu Ile Tyr Leu Thr Arg Leu Leu Ser Thr Lys Gly Thr Leu Gln Lys
                1765                1770                1775    
Phe Leu Asp Asp Leu Phe Lys Ala Ile Leu Ser Ile Arg Glu Asp Lys
            1780                1785                1790        
Pro Pro Leu Ala Val Lys Tyr Phe Phe Asp Phe Leu Glu Glu Gln Ala
        1795                1800                1805            
Glu Lys Arg Gly Ile Ser Asp Pro Asp Thr Leu His Ile Trp Lys Thr
    1810                1815                1820                
Asn Ser Leu Pro Leu Arg Phe Trp Val Asn Ile Leu Lys Asn Pro Gln
1825                1830                1835                1840
Phe Val Phe Asp Ile Asp Lys Thr Asp His Ile Asp Ala Cys Leu Ser
                1845                1850                1855    
Val Ile Ala Gln Ala Phe Ile Asp Ala Cys Ser Ile Ser Asp Leu Gln
            1860                1865                1870        
Leu Gly Lys Asp Ser Pro Thr Asn Lys Leu Leu Tyr Ala Lys Glu Ile
        1875                1880                1885            
Pro Glu Tyr Arg Lys Ile Val Gln Arg Tyr Tyr Lys Gln Ile Gln Asp
    1890                1895                1900                
Met Thr Pro Leu Ser Glu Gln Glu Met Asn Ala His Leu Ala Glu Glu
1905                1910                1915                1920
Ser Arg Lys Tyr Gln Asn Glu Phe Asn Thr Asn Val Ala Met Ala Glu
                1925                1930                1935    
Ile Tyr Lys Tyr Ala Lys Arg Tyr Arg Pro Gln Ile Met Ala Ala Leu
            1940                1945                1950        
Glu Ala Asn Pro Thr Ala Arg Arg Thr Gln Leu Gln His Lys Phe Glu
        1955                1960                1965            
Gln Val Val Ala Leu Met Glu Asp Asn Ile Tyr Glu Cys Tyr Ser Glu
    1970                1975                1980                
Ala
1985


<210> 327
<211> 343
<212> PRT
<213> Homo sapiens

<400> 327
Met Tyr Leu Asn Val Ile Ile Asn Asn Thr Trp Gln Gly Asp Phe Ser
 1               5                  10                  15      
Gln Ile Lys Val Phe Leu Met Thr Leu Lys Lys Asn Met Ile Ser Lys
            20                  25                  30          
Leu Lys Thr Glu Cys Gly Cys Gln Phe Thr Ser Lys Leu Glu Gly Met
        35                  40                  45              
Phe Arg Asp Met Ser Ile Ser Asn Thr Thr Met Asp Glu Phe Arg Gln
    50                  55                  60                  
His Leu Gln Ala Thr Gly Val Ser Leu Gly Gly Val Asp Leu Thr Val
65                  70                  75                  80  
Arg Val Leu Thr Thr Gly Tyr Trp Pro Thr Gln Ser Ala Thr Pro Lys
                85                  90                  95      
Cys Asn Ile Pro Pro Ala Pro Arg His Ala Phe Glu Ile Phe Arg Arg
            100                 105                 110         
Phe Tyr Leu Ala Lys His Ser Gly Arg Gln Leu Thr Leu Gln His His
        115                 120                 125             
Met Gly Ser Ala Asp Leu Asn Ala Thr Phe Tyr Gly Pro Val Lys Lys
    130                 135                 140                 
Glu Asp Gly Ser Glu Val Gly Val Gly Gly Ala Gln Val Thr Gly Ser
145                 150                 155                 160 
Asn Thr Arg Lys His Ile Leu Gln Val Ser Thr Phe Gln Met Thr Ile
                165                 170                 175     
Leu Met Leu Phe Asn Asn Arg Glu Lys Tyr Thr Phe Glu Glu Ile Gln
            180                 185                 190         
Gln Glu Thr Asp Ile Pro Glu Arg Glu Leu Val Arg Ala Leu Gln Ser
        195                 200                 205             
Leu Ala Cys Gly Lys Pro Thr Gln Arg Val Leu Thr Lys Glu Pro Lys
    210                 215                 220                 
Ser Lys Glu Ile Glu Asn Gly His Ile Phe Thr Val Asn Asp Gln Phe
225                 230                 235                 240 
Thr Ser Lys Leu His Arg Val Lys Ile Gln Thr Val Ala Ala Lys Gln
                245                 250                 255     
Gly Glu Ser Asp Pro Glu Arg Lys Glu Thr Arg Gln Lys Val Asp Asp
            260                 265                 270         
Asp Arg Lys His Glu Ile Glu Ala Ala Ile Val Arg Ile Met Lys Ser
        275                 280                 285             
Arg Lys Lys Met Gln His Asn Val Leu Val Ala Glu Val Thr Gln Gln
    290                 295                 300                 
Leu Lys Ala Arg Phe Leu Pro Ser Pro Val Val Ile Lys Lys Arg Ile
305                 310                 315                 320 
Glu Gly Leu Ile Glu Arg Glu Tyr Leu Ala Arg Thr Pro Glu Asp Arg
                325                 330                 335     
Lys Val Tyr Thr Tyr Val Ala
            340             


<210> 328
<211> 130
<212> PRT
<213> Homo sapiens

<400> 328
Lys Val Phe Glu Arg Cys Glu Leu Ala Arg Thr Leu Lys Arg Leu Gly
 1               5                  10                  15      
Met Asp Gly Tyr Arg Gly Ile Ser Leu Ala Asn Trp Met Cys Leu Ala
            20                  25                  30          
Lys Trp Glu Ser Gly Tyr Asn Thr Arg Ala Thr Asn Tyr Asn Ala Gly
        35                  40                  45              
Asp Arg Ser Thr Asp Tyr Gly Leu Phe Gln Ile Asn Ser Arg Tyr Trp
    50                  55                  60                  
Cys Asn Asp Gly Lys Thr Pro Gly Ala Val Asn Ala Cys His Leu Ser
65                  70                  75                  80  
Cys Ser Ala Leu Leu Gln Asp Asn Ile Ala Asp Ala Val Ala Cys Ala
                85                  90                  95      
Lys Arg Val Val Arg Asp Pro Gln Gly Ile Arg Ala Trp Val Ala Trp
            100                 105                 110         
Arg Asn Arg Cys Gln Asn Arg Asp Val Arg Gln Tyr Val Gln Gly Cys
        115                 120                 125             
Gly Val
    130 


<210> 329
<211> 130
<212> PRT
<213> Homo sapiens

<400> 329
Lys Val Phe Glu Arg Cys Glu Leu Ala Arg Thr Leu Lys Arg Leu Gly
 1               5                  10                  15      
Met Asp Gly Tyr Arg Gly Ile Ser Leu Ala Asn Trp Met Cys Leu Ala
            20                  25                  30          
Lys Trp Glu Ser Gly Tyr Asn Thr Arg Ala Thr Asn Tyr Asn Ala Gly
        35                  40                  45              
Asp Arg Ser Thr Asp Tyr Gly Ile Phe Gln Leu Asn Ser Arg Tyr Trp
    50                  55                  60                  
Cys Asn Asp Gly Lys Thr Pro Gly Ala Val Asn Ala Cys His Leu Ser
65                  70                  75                  80  
Cys Ser Ala Leu Leu Gln Asp Asn Ile Ala Asp Ala Val Ala Cys Ala
                85                  90                  95      
Lys Arg Val Val Arg Asp Pro Gln Gly Ile Arg Ala Trp Val Ala Trp
            100                 105                 110         
Arg Asn Arg Cys Gln Asn Arg Asp Val Arg Gln Tyr Val Gln Gly Cys
        115                 120                 125             
Gly Val
    130 


<210> 330
<211> 463
<212> PRT
<213> Homo sapiens

<400> 330
Met Ala Ala Leu Arg Ala Leu Cys Gly Phe Arg Gly Val Ala Ala Gln
 1               5                  10                  15      
Val Leu Arg Pro Gly Ala Gly Gly Arg Leu Pro Ile Gln Pro Ser Arg
            20                  25                  30          
Gly Val Arg Gln Trp Gln Pro Asp Val Glu Trp Ala Gln Gln Phe Gly
        35                  40                  45              
Gly Ala Val Met Tyr Pro Ser Lys Glu Thr Ala His Trp Lys Pro Pro
    50                  55                  60                  
Pro Trp Asn Asp Val Asp Pro Pro Lys Asp Thr Ile Val Lys Asn Ile
65                  70                  75                  80  
Thr Leu Asn Phe Gly Pro Gln His Pro Ala Ala His Gly Val Leu Arg
                85                  90                  95      
Leu Val Met Glu Leu Ser Gly Glu Met Val Arg Lys Cys Asp Pro His
            100                 105                 110         
Ile Gly Leu Leu His Arg Gly Thr Glu Lys Leu Ile Glu Tyr Lys Thr
        115                 120                 125             
Tyr Leu Gln Ala Leu Pro Tyr Phe Asp Arg Leu Asp Tyr Val Ser Met
    130                 135                 140                 
Met Cys Asn Glu Gln Ala Tyr Ser Leu Ala Val Glu Lys Leu Leu Asn
145                 150                 155                 160 
Ile Arg Pro Pro Pro Arg Ala Gln Trp Ile Arg Val Leu Phe Gly Glu
                165                 170                 175     
Ile Thr Arg Leu Leu Asn His Ile Met Ala Val Thr Thr His Ala Leu
            180                 185                 190         
Asp Leu Gly Ala Met Thr Pro Phe Phe Trp Leu Phe Glu Glu Arg Glu
        195                 200                 205             
Lys Met Phe Glu Phe Tyr Glu Arg Val Ser Gly Ala Arg Met His Ala
    210                 215                 220                 
Ala Tyr Ile Arg Pro Gly Gly Val His Gln Asp Leu Pro Leu Gly Leu
225                 230                 235                 240 
Met Asp Asp Ile Tyr Gln Phe Ser Lys Asn Phe Ser Leu Arg Leu Asp
                245                 250                 255     
Glu Leu Glu Glu Leu Leu Thr Asn Asn Arg Ile Trp Arg Asn Arg Thr
            260                 265                 270         
Ile Asp Ile Gly Val Val Thr Ala Glu Glu Ala Leu Asn Tyr Gly Phe
        275                 280                 285             
Ser Gly Val Met Leu Arg Gly Ser Gly Ile Gln Trp Asp Leu Arg Lys
    290                 295                 300                 
Thr Gln Pro Tyr Asp Val Tyr Asp Gln Val Glu Phe Asp Val Pro Val
305                 310                 315                 320 
Gly Ser Arg Gly Asp Cys Tyr Asp Arg Tyr Leu Cys Arg Val Glu Glu
                325                 330                 335     
Met Arg Gln Ser Leu Arg Ile Ile Ala Gln Cys Leu Asn Lys Met Pro
            340                 345                 350         
Pro Gly Glu Ile Lys Val Asp Asp Ala Lys Val Ser Pro Pro Lys Arg
        355                 360                 365             
Ala Glu Met Lys Thr Ser Met Glu Ser Leu Ile His His Phe Lys Leu
    370                 375                 380                 
Tyr Thr Glu Gly Tyr Gln Val Pro Pro Gly Ala Thr Tyr Thr Ala Ile
385                 390                 395                 400 
Glu Ala Pro Lys Gly Glu Phe Gly Val Tyr Leu Val Ser Asp Gly Ser
                405                 410                 415     
Ser Arg Pro Tyr Arg Cys Lys Ile Lys Ala Pro Gly Phe Ala His Leu
            420                 425                 430         
Ala Gly Leu Asp Lys Met Ser Lys Gly His Met Leu Ala Asp Val Val
        435                 440                 445             
Ala Ile Ile Gly Thr Gln Asp Ile Val Phe Gly Glu Val Asp Arg
    450                 455                 460             


<210> 331
<211> 201
<212> PRT
<213> Homo sapiens

<400> 331
Val Ser Asp Pro Glu Glu Met Glu Leu Arg Gly Leu Gln Arg Glu Tyr
 1               5                  10                  15      
Pro Val Pro Ala Ser Lys Arg Pro Pro Leu Arg Gly Val Glu Arg Ser
            20                  25                  30          
Tyr Ala Ser Pro Ser Asp Asn Ser Ser Ala Glu Glu Glu Asp Pro Asp
        35                  40                  45              
Gly Glu Glu Glu Arg Cys Ala Leu Gly Thr Ala Gly Ser Ala Glu Gly
    50                  55                  60                  
Cys Lys Arg Lys Arg Pro Arg Gly Ala Gly Gly Gly Gly Ala Gly Gly
65                  70                  75                  80  
Ser Ala Gly Gly Gly Gly Lys Lys Pro Leu Pro Ala Lys Gly Ser Ala
                85                  90                  95      
Ala Glu Cys Lys Gln Ser Gln Arg Asn Ala Ala Asn Ala Arg Glu Arg
            100                 105                 110         
Ala Arg Met Arg Val Leu Ser Lys Ala Phe Ser Arg Leu Lys Thr Ser
        115                 120                 125             
Leu Pro Trp Val Pro Pro Asp Thr Lys Leu Ser Lys Leu Asp Thr Leu
    130                 135                 140                 
Arg Leu Ala Ser Ser Tyr Ile Ala His Leu Arg Gln Leu Leu Gln Glu
145                 150                 155                 160 
Asp Arg Tyr Glu Asn Gly Tyr Val His Pro Val Asn Leu Thr Trp Pro
                165                 170                 175     
Phe Val Val Ser Gly Arg Pro Asp Ser Asp Thr Lys Glu Val Ser Ala
            180                 185                 190         
Ala Asn Arg Leu Cys Gly Thr Thr Ala
        195                 200     


<210> 332
<211> 1380
<212> PRT
<213> Homo sapiens

<400> 332
Met Ala Ser Gly Arg Asp Glu Arg Pro Pro Trp Arg Leu Gly Arg Leu
 1               5                  10                  15      
Leu Leu Leu Met Cys Leu Leu Leu Leu Gly Ser Ser Ala Arg Ala Ala
            20                  25                  30          
His Ile Lys Lys Ala Glu Ala Thr Thr Thr Thr Thr Ser Ala Gly Ala
        35                  40                  45              
Glu Ala Ala Glu Gly Gln Phe Asp Arg Tyr Tyr His Glu Glu Glu Leu
    50                  55                  60                  
Glu Ser Ala Leu Arg Glu Ala Ala Ala Ala Gly Leu Pro Gly Leu Ala
65                  70                  75                  80  
Arg Leu Phe Ser Ile Gly Arg Ser Val Glu Gly Arg Pro Leu Trp Val
                85                  90                  95      
Leu Arg Leu Thr Ala Gly Leu Gly Ser Leu Ile Pro Glu Gly Asp Ala
            100                 105                 110         
Gly Pro Asp Ala Ala Gly Pro Asp Ala Ala Gly Pro Leu Leu Pro Gly
        115                 120                 125             
Arg Pro Gln Val Lys Leu Val Gly Asn Met His Gly Asp Glu Thr Val
    130                 135                 140                 
Ser Arg Gln Val Leu Ile Tyr Leu Ala Arg Glu Leu Ala Ala Gly Tyr
145                 150                 155                 160 
Arg Arg Gly Asp Pro Arg Leu Val Arg Leu Leu Asn Thr Thr Asp Val
                165                 170                 175     
Tyr Leu Leu Pro Ser Leu Asn Pro Asp Gly Phe Glu Arg Ala Arg Glu
            180                 185                 190         
Gly Asp Cys Gly Phe Gly Asp Gly Gly Pro Ser Gly Ala Ser Gly Arg
        195                 200                 205             
Asp Asn Ser Arg Gly Arg Asp Leu Asn Arg Ser Phe Pro Asp Gln Phe
    210                 215                 220                 
Ser Thr Gly Glu Pro Pro Ala Leu Asp Glu Val Pro Glu Val Arg Ala
225                 230                 235                 240 
Leu Ile Glu Trp Ile Arg Arg Asn Lys Phe Val Leu Ser Gly Asn Leu
                245                 250                 255     
His Gly Gly Ser Val Val Ala Ser Tyr Pro Phe Asp Asp Ser Pro Glu
            260                 265                 270         
His Lys Ala Thr Gly Ile Tyr Ser Lys Thr Ser Asp Asp Glu Val Phe
        275                 280                 285             
Lys Tyr Leu Ala Lys Ala Tyr Ala Ser Asn His Pro Ile Met Lys Thr
    290                 295                 300                 
Gly Glu Pro His Cys Pro Gly Asp Glu Asp Glu Thr Phe Lys Asp Gly
305                 310                 315                 320 
Ile Thr Asn Gly Ala His Trp Tyr Asp Val Glu Gly Gly Met Gln Asp
                325                 330                 335     
Tyr Asn Tyr Val Trp Ala Asn Cys Phe Glu Ile Thr Leu Glu Leu Ser
            340                 345                 350         
Cys Cys Lys Tyr Pro Pro Ala Ser Gln Leu Arg Gln Glu Trp Glu Asn
        355                 360                 365             
Asn Arg Glu Ser Leu Ile Thr Leu Ile Glu Lys Val His Ile Gly Val
    370                 375                 380                 
Lys Gly Phe Val Lys Asp Ser Ile Thr Gly Ser Gly Leu Glu Asn Ala
385                 390                 395                 400 
Thr Ile Ser Val Ala Gly Ile Asn His Asn Ile Thr Thr Gly Arg Phe
                405                 410                 415     
Gly Asp Phe Tyr Arg Leu Leu Val Pro Gly Thr Tyr Asn Leu Thr Val
            420                 425                 430         
Val Leu Thr Gly Tyr Met Pro Leu Thr Val Thr Asn Val Val Val Lys
        435                 440                 445             
Glu Gly Pro Ala Thr Glu Val Asp Phe Ser Leu Arg Pro Thr Val Thr
    450                 455                 460                 
Ser Val Ile Pro Asp Thr Thr Glu Ala Val Ser Thr Ala Ser Thr Val
465                 470                 475                 480 
Ala Ile Pro Asn Ile Leu Ser Gly Thr Ser Ser Ser Tyr Gln Pro Ile
                485                 490                 495     
Gln Pro Lys Asp Phe His His His His Phe Pro Asp Met Glu Ile Phe
            500                 505                 510         
Leu Arg Arg Phe Ala Asn Glu Tyr Pro Asn Ile Thr Arg Leu Tyr Ser
        515                 520                 525             
Leu Gly Lys Ser Val Glu Ser Arg Glu Leu Tyr Val Met Glu Ile Ser
    530                 535                 540                 
Asp Asn Pro Gly Val His Glu Pro Gly Glu Pro Glu Phe Lys Tyr Ile
545                 550                 555                 560 
Gly Asn Met His Gly Asn Glu Val Val Gly Arg Glu Leu Leu Leu Asn
                565                 570                 575     
Leu Ile Glu Tyr Leu Cys Lys Asn Phe Gly Thr Asp Pro Glu Val Thr
            580                 585                 590         
Asp Leu Val His Asn Thr Arg Ile His Leu Met Pro Ser Met Asn Pro
        595                 600                 605             
Asp Gly Tyr Glu Lys Ser Gln Glu Gly Asp Ser Ile Ser Val Ile Gly
    610                 615                 620                 
Arg Asn Asn Ser Asn Asn Phe Asp Leu Asn Arg Asn Phe Pro Asp Gln
625                 630                 635                 640 
Phe Val Gln Ile Thr Asp Pro Thr Gln Pro Glu Thr Ile Ala Val Met
                645                 650                 655     
Ser Trp Met Lys Ser Tyr Pro Phe Val Leu Ser Ala Asn Leu His Gly
            660                 665                 670         
Gly Ser Leu Val Val Asn Tyr Pro Phe Asp Asp Asp Glu Gln Gly Leu
        675                 680                 685             
Ala Thr Tyr Ser Lys Ser Pro Asp Asp Ala Val Phe Gln Gln Ile Ala
    690                 695                 700                 
Leu Ser Tyr Ser Lys Glu Asn Ser Gln Met Phe Gln Gly Arg Pro Cys
705                 710                 715                 720 
Lys Asn Met Tyr Pro Asn Glu Tyr Phe Pro His Gly Ile Thr Asn Gly
                725                 730                 735     
Ala Ser Trp Tyr Asn Val Pro Gly Gly Met Gln Asp Trp Asn Tyr Leu
            740                 745                 750         
Gln Thr Asn Cys Phe Glu Val Thr Ile Glu Leu Gly Cys Val Lys Tyr
        755                 760                 765             
Pro Leu Glu Lys Glu Leu Pro Asn Phe Trp Glu Gln Asn Arg Arg Ser
    770                 775                 780                 
Leu Ile Gln Phe Met Lys Gln Val His Gln Gly Val Arg Gly Phe Val
785                 790                 795                 800 
Leu Asp Ala Thr Asp Gly Arg Gly Ile Leu Asn Ala Thr Ile Ser Val
                805                 810                 815     
Ala Glu Ile Asn His Pro Val Thr Thr Tyr Lys Thr Gly Asp Tyr Trp
            820                 825                 830         
Arg Leu Leu Val Pro Gly Thr Tyr Lys Ile Thr Ala Ser Ala Arg Gly
        835                 840                 845             
Tyr Asn Pro Val Thr Lys Asn Val Thr Val Lys Ser Glu Gly Ala Ile
    850                 855                 860                 
Gln Val Asn Phe Thr Leu Val Arg Ser Ser Thr Asp Ser Asn Asn Glu
865                 870                 875                 880 
Ser Lys Lys Gly Lys Gly Ala Ser Ser Ser Thr Asn Asp Ala Ser Val
                885                 890                 895     
Pro Thr Thr Lys Glu Phe Glu Thr Leu Ile Lys Asp Leu Ser Ala Glu
            900                 905                 910         
Asn Gly Leu Glu Ser Leu Met Leu Arg Ser Ser Ser Asn Leu Ala Leu
        915                 920                 925             
Ala Leu Tyr Arg Tyr His Ser Tyr Lys Asp Leu Ser Glu Phe Leu Arg
    930                 935                 940                 
Gly Leu Val Met Asn Tyr Pro His Ile Thr Asn Leu Thr Asn Leu Gly
945                 950                 955                 960 
Gln Ser Thr Glu Tyr Arg His Ile Trp Ser Leu Glu Ile Ser Asn Lys
                965                 970                 975     
Pro Asn Val Ser Glu Pro Glu Glu Pro Lys Ile Arg Phe Val Ala Gly
            980                 985                 990         
Ile His Gly Asn Ala Pro Val Gly Thr Glu Leu Leu Leu Ala Leu Ala
        995                 1000                1005            
Glu Phe Leu Cys Leu Asn Tyr Lys Lys Asn Pro Ala Val Thr Gln Leu
    1010                1015                1020                
Val Asp Arg Thr Arg Ile Val Ile Val Pro Ser Leu Asn Pro Asp Gly
1025                1030                1035                1040
Arg Glu Arg Ala Gln Glu Lys Asp Cys Thr Ser Lys Ile Gly Gln Thr
                1045                1050                1055    
Asn Ala Arg Gly Lys Asp Leu Asp Thr Asp Phe Thr Asn Asn Ala Ser
            1060                1065                1070        
Gln Pro Glu Thr Lys Ala Ile Ile Glu Asn Leu Ile Gln Lys Gln Asp
        1075                1080                1085            
Phe Ser Leu Ser Val Ala Leu Asp Gly Gly Ser Met Leu Val Thr Tyr
    1090                1095                1100                
Pro Tyr Asp Lys Pro Val Gln Thr Val Glu Asn Lys Glu Thr Leu Lys
1105                1110                1115                1120
His Leu Ala Ser Leu Tyr Ala Asn Asn His Pro Ser Met His Met Gly
                1125                1130                1135    
Gln Pro Ser Cys Pro Asn Lys Ser Asp Glu Asn Ile Pro Gly Gly Val
            1140                1145                1150        
Met Arg Gly Ala Glu Trp His Ser His Leu Gly Ser Met Lys Asp Tyr
        1155                1160                1165            
Ser Val Thr Tyr Gly His Cys Pro Glu Ile Thr Val Tyr Thr Ser Cys
    1170                1175                1180                
Cys Tyr Phe Pro Ser Ala Ala Arg Leu Pro Ser Leu Trp Ala Asp Asn
1185                1190                1195                1200
Lys Arg Ser Leu Leu Ser Met Leu Val Glu Val His Lys Gly Val His
                1205                1210                1215    
Gly Phe Val Lys Asp Lys Thr Gly Lys Pro Ile Ser Lys Ala Val Ile
            1220                1225                1230        
Val Leu Asn Glu Gly Ile Lys Val Gln Thr Lys Glu Gly Gly Tyr Phe
        1235                1240                1245            
His Val Leu Leu Ala Pro Gly Val His Asn Ile Ile Ala Ile Ala Asp
    1250                1255                1260                
Gly Tyr Gln Gln Gln His Ser Gln Val Phe Val His His Asp Ala Ala
1265                1270                1275                1280
Ser Ser Val Val Ile Val Phe Asp Thr Asp Asn Arg Ile Phe Gly Leu
                1285                1290                1295    
Pro Arg Glu Leu Val Val Thr Val Ser Gly Ala Thr Met Ser Ala Leu
            1300                1305                1310        
Ile Leu Thr Ala Cys Ile Ile Trp Cys Ile Cys Ser Ile Lys Ser Asn
        1315                1320                1325            
Arg His Lys Asp Gly Phe His Arg Leu Arg Gln His His Asp Glu Tyr
    1330                1335                1340                
Glu Asp Glu Ile Arg Met Met Ser Thr Gly Ser Lys Lys Ser Leu Leu
1345                1350                1355                1360
Ser His Glu Phe Gln Asp Glu Thr Asp Thr Glu Glu Glu Thr Leu Tyr
                1365                1370                1375    
Ser Ser Lys His
            1380


<210> 333
<211> 1380
<212> PRT
<213> Homo sapiens

<400> 333
Met Ala Ser Gly Arg Asp Glu Arg Pro Pro Trp Arg Leu Gly Arg Leu
 1               5                  10                  15      
Leu Leu Leu Met Cys Leu Leu Leu Leu Gly Ser Ser Ala Arg Ala Ala
            20                  25                  30          
His Ile Lys Lys Ala Glu Ala Thr Thr Thr Thr Thr Ser Ala Gly Ala
        35                  40                  45              
Glu Ala Ala Glu Gly Gln Phe Asp Arg Tyr Tyr His Glu Glu Glu Leu
    50                  55                  60                  
Glu Ser Ala Leu Arg Glu Ala Ala Ala Ala Gly Leu Pro Gly Leu Ala
65                  70                  75                  80  
Arg Leu Phe Ser Ile Gly Arg Ser Val Glu Gly Arg Pro Leu Trp Val
                85                  90                  95      
Leu Arg Leu Thr Ala Gly Leu Gly Ser Leu Ile Pro Glu Gly Asp Ala
            100                 105                 110         
Gly Pro Asp Ala Ala Gly Pro Asp Ala Ala Gly Pro Leu Leu Pro Gly
        115                 120                 125             
Arg Pro Gln Val Lys Leu Val Gly Asn Met His Gly Asp Glu Thr Val
    130                 135                 140                 
Ser Arg Gln Val Leu Ile Tyr Leu Ala Arg Glu Leu Ala Ala Gly Tyr
145                 150                 155                 160 
Arg Arg Gly Asp Pro Arg Leu Val Arg Leu Leu Asn Thr Thr Asp Val
                165                 170                 175     
Tyr Leu Leu Pro Ser Leu Asn Pro Asp Gly Phe Glu Arg Ala Arg Glu
            180                 185                 190         
Gly Asp Cys Gly Phe Gly Asp Gly Gly Pro Ser Gly Ala Ser Gly Arg
        195                 200                 205             
Asp Asn Ser Arg Gly Arg Asp Leu Asn Arg Ser Phe Pro Asp Gln Phe
    210                 215                 220                 
Ser Thr Gly Glu Pro Pro Ala Leu Asp Glu Val Pro Glu Val Arg Ala
225                 230                 235                 240 
Leu Ile Glu Trp Ile Arg Arg Asn Lys Phe Val Leu Ser Gly Asn Leu
                245                 250                 255     
His Gly Gly Ser Val Val Ala Ser Tyr Pro Phe Asp Asp Ser Pro Glu
            260                 265                 270         
His Lys Ala Thr Gly Ile Tyr Ser Lys Thr Ser Asp Asp Glu Val Phe
        275                 280                 285             
Lys Tyr Leu Ala Lys Ala Tyr Ala Ser Asn His Pro Ile Met Lys Thr
    290                 295                 300                 
Gly Glu Pro His Cys Pro Gly Asp Glu Asp Glu Thr Phe Lys Asp Gly
305                 310                 315                 320 
Ile Thr Asn Gly Ala His Trp Tyr Asp Val Glu Gly Gly Met Gln Asp
                325                 330                 335     
Tyr Asn Tyr Val Trp Ala Asn Cys Phe Glu Ile Thr Leu Glu Leu Ser
            340                 345                 350         
Cys Cys Lys Tyr Pro Pro Ala Ser Gln Leu Arg Gln Glu Trp Glu Asn
        355                 360                 365             
Asn Arg Glu Ser Leu Ile Thr Leu Ile Glu Lys Val His Ile Gly Val
    370                 375                 380                 
Lys Gly Phe Val Lys Asp Ser Ile Thr Gly Ser Gly Leu Glu Asn Ala
385                 390                 395                 400 
Thr Ile Ser Val Ala Gly Ile Asn His Asn Ile Thr Thr Gly Arg Phe
                405                 410                 415     
Gly Asp Phe Tyr Arg Leu Leu Val Pro Gly Thr Tyr Asn Leu Thr Val
            420                 425                 430         
Val Leu Thr Gly Tyr Met Pro Leu Thr Val Thr Asn Val Val Val Lys
        435                 440                 445             
Glu Gly Pro Ala Thr Glu Val Asp Phe Ser Leu Arg Pro Thr Val Thr
    450                 455                 460                 
Ser Val Ile Pro Asp Thr Thr Glu Ala Val Ser Thr Ala Ser Thr Val
465                 470                 475                 480 
Ala Ile Pro Asn Ile Leu Ser Gly Thr Ser Ser Ser Tyr Gln Pro Ile
                485                 490                 495     
Gln Pro Lys Asp Phe His His His His Phe Pro Asp Met Glu Ile Phe
            500                 505                 510         
Leu Arg Arg Phe Ala Asn Glu Tyr Pro Asn Ile Thr Arg Leu Tyr Ser
        515                 520                 525             
Leu Gly Lys Ser Val Glu Ser Arg Glu Leu Tyr Val Met Glu Ile Ser
    530                 535                 540                 
Asp Asn Pro Gly Val His Glu Pro Gly Glu Pro Glu Phe Lys Tyr Ile
545                 550                 555                 560 
Gly Asn Met His Gly Asn Glu Val Val Gly Arg Glu Leu Leu Leu Asn
                565                 570                 575     
Leu Ile Glu Tyr Leu Cys Lys Asn Phe Gly Thr Asp Pro Glu Val Thr
            580                 585                 590         
Asp Leu Val His Asn Thr Arg Ile His Leu Met Pro Ser Met Asn Pro
        595                 600                 605             
Asp Gly Tyr Glu Lys Ser Gln Glu Gly Asp Ser Ile Ser Val Ile Gly
    610                 615                 620                 
Arg Asn Asn Ser Asn Asn Phe Asp Leu Asn Arg Asn Phe Pro Asp Gln
625                 630                 635                 640 
Phe Val Gln Ile Thr Asp Pro Thr Gln Pro Glu Thr Ile Ala Val Met
                645                 650                 655     
Ser Trp Met Lys Ser Tyr Pro Phe Val Leu Ser Ala Asn Leu His Gly
            660                 665                 670         
Gly Ser Leu Val Val Asn Tyr Pro Phe Asp Asp Asp Glu Gln Gly Leu
        675                 680                 685             
Ala Thr Tyr Ser Lys Ser Pro Asp Asp Ala Val Phe Gln Gln Ile Ala
    690                 695                 700                 
Leu Ser Tyr Ser Lys Glu Asn Ser Gln Met Phe Gln Gly Arg Pro Cys
705                 710                 715                 720 
Lys Asn Met Tyr Pro Asn Glu Tyr Phe Pro His Gly Ile Thr Asn Gly
                725                 730                 735     
Ala Ser Trp Tyr Asn Val Pro Gly Gly Met Gln Asp Trp Asn Tyr Leu
            740                 745                 750         
Gln Thr Asn Cys Phe Glu Val Thr Ile Glu Leu Gly Cys Val Lys Tyr
        755                 760                 765             
Pro Leu Glu Lys Glu Leu Pro Asn Phe Trp Glu Gln Asn Arg Arg Ser
    770                 775                 780                 
Leu Ile Gln Phe Met Lys Gln Val His Gln Gly Val Arg Gly Phe Val
785                 790                 795                 800 
Leu Asp Ala Thr Asp Gly Arg Gly Ile Leu Asn Ala Thr Ile Ser Val
                805                 810                 815     
Ala Glu Ile Asn His Pro Val Thr Thr Tyr Lys Thr Gly Asp Tyr Trp
            820                 825                 830         
Arg Leu Leu Val Pro Gly Thr Tyr Lys Ile Thr Ala Ser Ala Arg Gly
        835                 840                 845             
Tyr Asn Pro Val Thr Lys Asn Val Thr Val Lys Ser Glu Gly Ala Ile
    850                 855                 860                 
Gln Val Asn Phe Thr Leu Val Arg Ser Ser Thr Asp Ser Asn Asn Glu
865                 870                 875                 880 
Ser Lys Lys Gly Lys Gly Ala Ser Ser Ser Thr Asn Asp Ala Ser Val
                885                 890                 895     
Pro Thr Thr Lys Glu Phe Glu Thr Leu Ile Lys Asp Leu Ser Ala Glu
            900                 905                 910         
Asn Gly Leu Glu Ser Leu Met Leu Arg Ser Ser Ser Asn Leu Ala Leu
        915                 920                 925             
Ala Leu Tyr Arg Tyr His Ser Tyr Lys Asp Leu Ser Glu Phe Leu Arg
    930                 935                 940                 
Gly Leu Val Met Asn Tyr Pro His Ile Thr Asn Leu Thr Asn Leu Gly
945                 950                 955                 960 
Gln Ser Thr Glu Tyr Arg His Ile Trp Ser Leu Glu Ile Ser Asn Lys
                965                 970                 975     
Pro Asn Val Ser Glu Pro Glu Glu Pro Lys Ile Arg Phe Val Ala Gly
            980                 985                 990         
Ile His Gly Asn Ala Pro Val Gly Thr Glu Leu Leu Leu Ala Leu Ala
        995                 1000                1005            
Glu Phe Leu Cys Leu Asn Tyr Lys Lys Asn Pro Ala Val Thr Gln Leu
    1010                1015                1020                
Val Asp Arg Thr Arg Ile Val Ile Val Pro Ser Leu Asn Pro Asp Gly
1025                1030                1035                1040
Arg Glu Arg Ala Gln Glu Lys Asp Cys Thr Ser Lys Ile Gly Gln Thr
                1045                1050                1055    
Asn Ala Arg Gly Lys Asp Leu Asp Thr Asp Phe Thr Asn Asn Ala Ser
            1060                1065                1070        
Gln Pro Glu Thr Lys Ala Ile Ile Glu Asn Leu Ile Gln Lys Gln Asp
        1075                1080                1085            
Phe Ser Leu Ser Val Ala Leu Asp Gly Gly Ser Met Leu Val Thr Tyr
    1090                1095                1100                
Pro Tyr Asp Lys Pro Val Gln Thr Val Glu Asn Lys Glu Thr Leu Lys
1105                1110                1115                1120
His Leu Ala Ser Leu Tyr Ala Asn Asn His Pro Ser Met His Met Gly
                1125                1130                1135    
Gln Pro Ser Cys Pro Asn Lys Ser Asp Glu Asn Ile Pro Gly Gly Val
            1140                1145                1150        
Met Arg Gly Ala Glu Trp His Ser His Leu Gly Ser Met Lys Asp Tyr
        1155                1160                1165            
Ser Val Thr Tyr Gly His Cys Pro Glu Ile Thr Val Tyr Thr Ser Cys
    1170                1175                1180                
Cys Tyr Phe Pro Ser Ala Ala Arg Leu Pro Ser Leu Trp Ala Asp Asn
1185                1190                1195                1200
Lys Arg Ser Leu Leu Ser Met Leu Val Glu Val His Lys Gly Val His
                1205                1210                1215    
Gly Phe Val Lys Asp Lys Thr Gly Lys Pro Ile Ser Lys Ala Val Ile
            1220                1225                1230        
Val Leu Asn Glu Gly Ile Lys Val Gln Thr Lys Glu Gly Gly Tyr Phe
        1235                1240                1245            
His Val Leu Leu Ala Pro Gly Val His Asn Ile Ile Ala Ile Ala Asp
    1250                1255                1260                
Gly Tyr Gln Gln Gln His Ser Gln Val Phe Val His His Asp Ala Ala
1265                1270                1275                1280
Ser Ser Val Val Ile Val Phe Asp Thr Asp Asn Arg Ile Phe Gly Leu
                1285                1290                1295    
Pro Arg Glu Leu Val Val Thr Val Ser Gly Ala Thr Met Ser Ala Leu
            1300                1305                1310        
Ile Leu Thr Ala Cys Ile Ile Trp Cys Ile Cys Ser Ile Lys Ser Asn
        1315                1320                1325            
Arg His Lys Asp Gly Phe His Arg Leu Arg Gln His His Asp Glu Tyr
    1330                1335                1340                
Glu Asp Glu Ile Arg Met Met Ser Thr Gly Ser Lys Lys Ser Leu Leu
1345                1350                1355                1360
Ser His Glu Phe Gln Asp Glu Thr Asp Thr Glu Glu Glu Thr Leu Tyr
                1365                1370                1375    
Ser Ser Lys His
            1380


<210> 334
<211> 107
<212> PRT
<213> Homo sapiens

<400> 334
Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro
 1               5                  10                  15      
Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp
            20                  25                  30          
Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe
        35                  40                  45              
Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala
    50                  55                  60                  
Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr
65                  70                  75                  80  
Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr
                85                  90                  95      
Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu
            100                 105         


<210> 335
<211> 224
<212> PRT
<213> Homo sapiens

<400> 335
Met Val Ala Ala Val Leu Leu Gly Leu Ser Trp Leu Cys Ser Pro Leu
 1               5                  10                  15      
Gly Ala Leu Val Leu Asp Phe Asn Asn Ile Arg Ser Ser Ala Asp Leu
            20                  25                  30          
His Gly Ala Arg Lys Gly Ser Gln Cys Leu Ser Asp Thr Asp Cys Asn
        35                  40                  45              
Thr Arg Lys Phe Cys Leu Gln Pro Arg Asp Glu Lys Pro Phe Cys Ala
    50                  55                  60                  
Thr Cys Arg Gly Leu Arg Arg Arg Cys Gln Arg Asp Ala Met Cys Cys
65                  70                  75                  80  
Pro Gly Thr Leu Cys Val Asn Asp Val Cys Thr Thr Leu Glu Asp Ala
                85                  90                  95      
Thr Pro Ile Leu Glu Arg Gln Leu Asp Glu Gln Asp Gly Thr His Ala
            100                 105                 110         
Glu Gly Thr Thr Gly His Pro Val Gln Glu Asn Gln Pro Lys Arg Lys
        115                 120                 125             
Pro Ser Ile Lys Lys Ser Gln Gly Arg Lys Gly Gln Glu Gly Glu Ser
    130                 135                 140                 
Cys Leu Arg Thr Phe Asp Cys Gly Pro Gly Leu Cys Cys Ala Arg His
145                 150                 155                 160 
Phe Trp Thr Lys Ile Cys Lys Pro Val Leu Leu Glu Gly Gln Val Cys
                165                 170                 175     
Ser Arg Arg Gly His Lys Asp Thr Ala Gln Ala Pro Glu Ile Phe Gln
            180                 185                 190         
Arg Cys Asp Cys Gly Pro Gly Leu Leu Cys Arg Ser Gln Leu Thr Ser
        195                 200                 205             
Asn Arg Gln His Ala Arg Leu Arg Val Cys Gln Lys Ile Glu Lys Leu
    210                 215                 220                 


<210> 336
<211> 1443
<212> PRT
<213> Homo sapiens

<400> 336
Glu Gln Pro Asn Gln Val Asn Tyr Gly Asn Ile Cys Thr Gly Leu Glu
 1               5                  10                  15      
Val Leu Ser Phe Leu Leu Thr Val Leu Gln Ser Pro Ala Ile Leu Ser
            20                  25                  30          
Ser Phe Lys Pro Leu Gln Arg Gly Ile Ala Ala Cys Met Thr Cys Gly
        35                  40                  45              
Asn Thr Lys Val Leu Arg Ala Val His Ser Leu Leu Ser Arg Leu Met
    50                  55                  60                  
Ser Ile Phe Pro Thr Glu Pro Lys Tyr Ile Val Leu Asn Asn Val Leu
65                  70                  75                  80  
Leu Ser Leu Cys Phe Ser Trp Leu Leu Leu Phe Cys Glu Thr Leu Gly
                85                  90                  95      
Asn Phe Tyr Ile Leu Gly Thr Leu Met Ile Leu Lys Ser Ala Cys Ser
            100                 105                 110         
Asn Asn Pro Ser Tyr Ile Asp Arg Leu Ile Ser Val Phe Met Arg Ser
        115                 120                 125             
Leu Gln Lys Met Val Arg Glu His Leu Asn Pro Gln Ala Ala Ser Gly
    130                 135                 140                 
Ser Thr Glu Ala Thr Ser Gly Thr Ser Glu Leu Val Met Leu Ser Leu
145                 150                 155                 160 
Glu Leu Val Lys Thr Arg Leu Ala Val Met Ser Met Glu Met Arg Lys
                165                 170                 175     
Asn Phe Ile Gln Ala Ile Leu Thr Ser Leu Ile Glu Lys Ser Pro Asp
            180                 185                 190         
Ala Lys Ile Leu Arg Ala Val Val Lys Ile Val Glu Glu Trp Val Lys
        195                 200                 205             
Asn Asn Ser Pro Met Ala Ala Asn Gln Thr Pro Thr Leu Arg Glu Lys
    210                 215                 220                 
Ser Ile Leu Leu Val Lys Met Met Thr Tyr Ile Glu Lys Arg Phe Pro
225                 230                 235                 240 
Glu Asp Leu Glu Leu Asn Ala Gln Phe Leu Asp Leu Val Asn Tyr Val
                245                 250                 255     
Tyr Arg Asp Glu Thr Leu Ser Gly Ser Glu Leu Thr Ala Lys Leu Glu
            260                 265                 270         
Pro Ala Phe Leu Ser Gly Leu Arg Cys Ala Gln Pro Leu Ile Arg Ala
        275                 280                 285             
Lys Phe Phe Glu Val Phe Asp Asn Ser Met Lys Arg Arg Val Tyr Glu
    290                 295                 300                 
Arg Leu Leu Tyr Val Thr Cys Ser Gln Asn Trp Glu Ala Met Gly Asn
305                 310                 315                 320 
His Phe Trp Ile Lys Gln Cys Ile Glu Thr Gly Ala Leu Leu Ser Ala
                325                 330                 335     
Phe Val Gln Leu Cys His Ile Ser Thr Thr Leu Ala Glu Lys Thr Trp
            340                 345                 350         
Val Gln Leu Phe Pro Arg Leu Trp Lys Ile Leu Ser Asp Arg Gln Gln
        355                 360                 365             
His Ala Leu Ala Gly Glu Ile Ser Pro Phe Leu Cys Ser Gly Ser His
    370                 375                 380                 
Gln Val Gln Arg Asp Cys Gln Pro Ser Ala Leu Asn Cys Phe Val Glu
385                 390                 395                 400 
Ala Met Ser Gln Cys Val Pro Pro Ile Pro Ile Arg Pro Cys Val Leu
                405                 410                 415     
Lys Tyr Leu Gly Lys Thr His Asn Leu Trp Phe Arg Ser Thr Leu Met
            420                 425                 430         
Leu Glu His Gln Ala Phe Glu Lys Gly Leu Ser Leu Gln Ile Lys Pro
        435                 440                 445             
Lys Gln Thr Thr Glu Phe Tyr Glu Gln Glu Ser Ile Thr Pro Pro Gln
    450                 455                 460                 
Gln Glu Ile Leu Asp Ser Leu Ala Glu Leu Tyr Ser Leu Leu Gln Glu
465                 470                 475                 480 
Glu Asp Met Trp Ala Gly Leu Trp Gln Lys Arg Cys Lys Tyr Ser Glu
                485                 490                 495     
Thr Ala Thr Ala Ile Ala Tyr Glu Gln His Gly Phe Phe Glu Gln Ala
            500                 505                 510         
Gln Glu Ser Tyr Glu Lys Ala Met Asp Lys Ala Lys Lys Glu His Glu
        515                 520                 525             
Arg Ser Asn Ala Ser Pro Ala Ile Phe Pro Glu Tyr Gln Leu Trp Glu
    530                 535                 540                 
Asp His Trp Ile Arg Cys Ser Lys Glu Leu Asn Gln Trp Glu Ala Leu
545                 550                 555                 560 
Thr Glu Tyr Gly Gln Ser Lys Gly His Ile Asn Pro Tyr Leu Val Leu
                565                 570                 575     
Glu Cys Ala Trp Arg Val Ser Asn Trp Thr Ala Met Lys Glu Ala Leu
            580                 585                 590         
Val Gln Val Glu Val Ser Cys Pro Lys Glu Met Ala Trp Lys Val Asn
        595                 600                 605             
Met Tyr Arg Gly Tyr Leu Ala Ile Cys His Pro Glu Glu Gln Gln Leu
    610                 615                 620                 
Ser Phe Ile Glu Arg Leu Val Glu Met Ala Ser Ser Leu Ala Ile Arg
625                 630                 635                 640 
Glu Trp Arg Arg Leu Pro His Val Val Ser His Val His Thr Pro Leu
                645                 650                 655     
Leu Gln Ser Leu Leu Cys Trp Ser His Gln Ala Ala Gln Gln Ile Ile
            660                 665                 670         
Glu Leu Gln Glu Ala Ala Gln Ile Asn Ala Gly Leu Gln Pro Thr Asn
        675                 680                 685             
Leu Gly Arg Asn Asn Ser Leu His Asp Met Lys Thr Val Val Lys Thr
    690                 695                 700                 
Trp Arg Asn Arg Leu Pro Ile Val Ser Asp Asp Leu Ser His Trp Ser
705                 710                 715                 720 
Ser Ile Phe Met Trp Arg Gln His His Tyr Gln Ala Ile Val Thr Ala
                725                 730                 735     
Tyr Glu Asn Ser Ser Gln His Asp Pro Ser Ser Asn Asn Ala Met Leu
            740                 745                 750         
Gly Val His Ala Ser Ala Ser Ala Ile Ile Gln Tyr Gly Lys Ile Ala
        755                 760                 765             
Arg Lys Gln Gly Leu Val Asn Val Ala Leu Asp Ile Leu Ser Arg Ile
    770                 775                 780                 
His Thr Ile Pro Thr Val Pro Ile Val Asp Cys Phe Gln Lys Ile Arg
785                 790                 795                 800 
Gln Gln Val Lys Cys Tyr Leu Gln Leu Ala Gly Val Met Gly Lys Asn
                805                 810                 815     
Glu Cys Met Gln Gly Leu Glu Val Ile Glu Ser Thr Asn Leu Lys Tyr
            820                 825                 830         
Phe Thr Lys Glu Met Thr Ala Glu Phe Tyr Ala Leu Lys Gly Met Phe
        835                 840                 845             
Leu Ala Gln Ile Asn Lys Ser Glu Glu Ala Asn Lys Ala Phe Ser Ala
    850                 855                 860                 
Ala Val Gln Met His Asp Val Leu Val Lys Ala Trp Ala Met Trp Gly
865                 870                 875                 880 
Asp Tyr Leu Glu Asn Ile Phe Val Lys Glu Arg Gln Leu His Leu Gly
                885                 890                 895     
Val Ser Ala Ile Thr Cys Tyr Leu His Ala Cys Arg His Gln Asn Glu
            900                 905                 910         
Ser Lys Ser Arg Lys Tyr Leu Ala Lys Val Leu Trp Leu Leu Ser Phe
        915                 920                 925             
Asp Asp Asp Lys Asn Thr Leu Ala Asp Ala Val Asp Lys Tyr Cys Ile
    930                 935                 940                 
Gly Val Pro Pro Ile Gln Trp Leu Ala Trp Ile Pro Gln Leu Leu Thr
945                 950                 955                 960 
Cys Leu Val Gly Ser Glu Gly Lys Leu Leu Leu Asn Leu Ile Ser Gln
                965                 970                 975     
Val Gly Arg Val Tyr Pro Gln Ala Val Tyr Phe Pro Ile Arg Thr Leu
            980                 985                 990         
Tyr Leu Thr Leu Lys Ile Glu Gln Arg Glu Arg Tyr Lys Ser Asp Phe
        995                 1000                1005            
Asp Phe Ser Val Pro Gly Ser Met Lys Leu His Asn Leu Ile Ser Lys
    1010                1015                1020                
Leu Lys Lys Trp Ile Lys Ile Leu Glu Ala Lys Thr Lys Gln Leu Pro
1025                1030                1035                1040
Lys Phe Phe Leu Ile Glu Glu Lys Cys Arg Phe Leu Ser Asn Phe Ser
                1045                1050                1055    
Ala Gln Thr Ala Glu Val Glu Ile Pro Gly Glu Phe Leu Met Pro Lys
            1060                1065                1070        
Pro Thr His Tyr Tyr Ile Lys Ile Ala Arg Phe Met Pro Arg Val Glu
        1075                1080                1085            
Ile Val Gln Lys His Asn Thr Ala Ala Arg Arg Leu Tyr Ile Arg Gly
    1090                1095                1100                
His Asn Gly Lys Ile Tyr Pro Tyr Leu Val Met Asn Asp Ala Cys Leu
1105                1110                1115                1120
Thr Glu Ser Arg Arg Glu Glu Arg Val Leu Gln Leu Leu Arg Leu Leu
                1125                1130                1135    
Asn Pro Cys Leu Glu Lys Arg Lys Glu Thr Thr Lys Arg His Leu Phe
            1140                1145                1150        
Phe Thr Val Pro Arg Val Val Ala Val Ser Pro Gln Met Arg Leu Val
        1155                1160                1165            
Glu Asp Asn Pro Ser Ser Leu Ser Leu Val Glu Ile Tyr Lys Gln Arg
    1170                1175                1180                
Cys Ala Lys Lys Gly Ile Glu His Asp Asn Pro Ile Ser Arg Tyr Tyr
1185                1190                1195                1200
Asp Arg Leu Ala Thr Val Gln Ala Arg Gly Thr Gln Ala Ser His Gln
                1205                1210                1215    
Val Leu Arg Asp Ile Leu Lys Glu Val Gln Ser Asn Met Val Pro Arg
            1220                1225                1230        
Ser Met Leu Lys Glu Trp Ala Leu His Thr Phe Pro Asn Ala Thr Asp
        1235                1240                1245            
Tyr Trp Thr Phe Arg Lys Met Phe Thr Ile Gln Leu Ala Leu Ile Gly
    1250                1255                1260                
Phe Ala Glu Phe Val Leu His Leu Asn Arg Leu Asn Pro Glu Met Leu
1265                1270                1275                1280
Gln Ile Ala Gln Asp Thr Gly Lys Leu Asn Val Ala Tyr Phe Arg Phe
                1285                1290                1295    
Asp Ile Asn Asp Ala Thr Gly Asp Leu Asp Ala Asn Arg Pro Val Pro
            1300                1305                1310        
Phe Arg Leu Thr Pro Asn Ile Ser Glu Phe Leu Thr Thr Ile Gly Val
        1315                1320                1325            
Ser Gly Pro Leu Thr Ala Ser Met Ile Ala Val Ala Arg Cys Phe Ala
    1330                1335                1340                
Gln Pro Asn Phe Lys Val Asp Gly Ile Leu Lys Thr Val Leu Arg Asp
1345                1350                1355                1360
Glu Ile Ile Ala Trp His Lys Lys Thr Gln Glu Asp Thr Ser Ser Pro
                1365                1370                1375    
Leu Ser Ala Ala Gly Gln Pro Glu Asn Met Asp Ser Gln Gln Leu Val
            1380                1385                1390        
Ser Leu Val Gln Lys Ala Val Thr Ala Ile Met Thr Arg Leu His Asn
        1395                1400                1405            
Leu Ala Gln Phe Glu Gly Gly Glu Ser Lys Val Asn Thr Leu Val Ala
    1410                1415                1420                
Ala Ala Asn Ser Leu Asp Asn Leu Cys Arg Met Asp Pro Ala Trp His
1425                1430                1435                1440
Pro Trp Leu
            


<210> 337
<211> 979
<212> PRT
<213> Homo sapiens

<400> 337
Met Asn Asn Ser Met Gly Arg Ala His Val Leu Ala His Pro Thr Ala
 1               5                  10                  15      
Ile Asp Thr Ile Ala Arg Ser Leu Ala Ala Asp Asn Ile Arg Thr Lys
            20                  25                  30          
Ile Ala Ala Leu Glu Ile Leu Gly Ala Val Cys Leu Val Pro Gly Gly
        35                  40                  45              
His Arg Lys Val Leu Gln Ala Met Leu His Phe Gln Val Phe Ala Thr
    50                  55                  60                  
Glu Arg Thr Arg Phe Gln Ser Ile Val Asn Asp Leu Asp Arg Ser Thr
65                  70                  75                  80  
Tyr Ala Tyr Arg Asp Asn Val Asn Leu Lys Thr Ala Leu Met Ser Phe
                85                  90                  95      
Val Asn Ala Val Leu Asn Tyr Gly Pro Gly Gln Glu Asn Leu Glu Phe
            100                 105                 110         
Arg Leu His Leu Arg Tyr Glu Phe Leu Met Leu Gly Ile Gln Pro Val
        115                 120                 125             
Ile Asp Lys Leu Arg Thr His Glu Asn Glu Thr Leu Asp Arg His Leu
    130                 135                 140                 
Asp Phe Phe Glu Met Val Arg Ala Glu Asp Glu Lys Glu Phe Ala Arg
145                 150                 155                 160 
Arg Phe Lys Glu Glu His Val Asp Thr Lys Ser Ala Gly Ser Met Phe
                165                 170                 175     
Glu Leu Leu Arg Arg Lys Leu Ser His Ser Pro Ala Tyr Pro His Met
            180                 185                 190         
Leu Ser Leu Leu Gln His Met Leu Leu Leu Pro Tyr Thr Gly His Cys
        195                 200                 205             
Thr Glu His Trp Leu Leu Ile Asp Arg Val Val Gln Gln Ile Val Leu
    210                 215                 220                 
Gln Val Glu Gln Arg Pro Asn Ser Asp Leu Ile Val Asp Pro Asp Asp
225                 230                 235                 240 
Pro Glu Lys Gln Leu Lys Leu Ala Ala Glu Ser Pro Val His Asp Pro
                245                 250                 255     
Asp Val Ala Pro Leu Gln Ile Asp Val Ala Lys Leu Val Arg Leu Leu
            260                 265                 270         
Val Lys Glu Glu Gln Leu Thr Gln Ala Arg Lys Arg Ala Asp Glu Leu
        275                 280                 285             
Glu Arg Glu Asn Phe Asp Val Gln Ser Arg Leu Ala Lys Lys Glu Gln
    290                 295                 300                 
Glu Leu Asp Leu Arg Met Gln Glu Lys Glu Asp Leu Glu Thr Gly Leu
305                 310                 315                 320 
Ala Arg Met Arg Glu Arg Leu Glu Lys Glu Ser Ala Gln His Ser Gln
                325                 330                 335     
Ala Val Gln Arg Ala Gln Thr Ala Glu Met Arg Ala Glu Asp Leu Gln
            340                 345                 350         
His Arg Leu Ile Ser Glu Gln Gln Glu Arg Ala Arg Leu Glu Arg Leu
        355                 360                 365             
Val Thr Glu Gly Ser Ile Pro Asp Asp Gln Lys Val Ala Gly Leu Thr
    370                 375                 380                 
Gly Cys Asn Gly Ala Val Ser Pro Pro Pro Ala Pro Pro Met Leu Lys
385                 390                 395                 400 
Ala Ile Pro Pro Pro Pro Pro Pro Met Ala Pro Ser Met Met Pro Pro
                405                 410                 415     
Pro Pro Pro Pro Cys Pro Gly Ala Pro Pro Pro Pro Pro Ser Met Ala
            420                 425                 430         
Gln Thr Met Ala Pro Ala Pro Pro Lys Val Asp Leu Pro Lys Lys Asn
        435                 440                 445             
Val Pro Gln Pro Thr Asn Pro Leu Lys Ser Phe Asn Trp Ser Lys Leu
    450                 455                 460                 
Pro Asp Ala Lys Leu Gln Gly Thr Val Trp Ser Glu Leu Asp Glu Ser
465                 470                 475                 480 
Lys Leu Tyr Asn Asn Met Glu Leu Glu Ser Ile Asp Lys Leu Phe Ser
                485                 490                 495     
Ala Tyr Gln Lys Asn Gly Val Ser Ala Thr Asp Gly Ser Tyr Glu Asp
            500                 505                 510         
Leu Arg Val Thr Gly Lys Ala Ala Lys Gln Lys Val Leu Ser Val Ile
        515                 520                 525             
Asp Gly Arg Arg Ala Gln Asn Cys Thr Ile Leu Leu Ser Lys Leu Lys
    530                 535                 540                 
Met Ser Asp Met Glu Ile Ser Lys Ala Ile Leu Ser Met Asp Ser Asn
545                 550                 555                 560 
Glu Gln Leu Gln Leu Asp Met Val Glu Gln Leu Leu Lys Phe Thr Pro
                565                 570                 575     
Ser Ala Glu Glu Arg Ala Leu Leu Asp Glu His Ser Glu Asp Ile Glu
            580                 585                 590         
Ser Leu Ala Arg Ala Asp Arg Phe Leu Tyr Glu Ile Ser Lys Ile Pro
        595                 600                 605             
His Tyr Glu Gln Arg Leu Lys Ser Leu His Tyr Lys Lys Arg Phe Met
    610                 615                 620                 
Leu Thr Ile Asn Asp Leu Val Pro Arg Ile Thr Ser Val Met Glu Ala
625                 630                 635                 640 
Ser Arg Glu Val Ala Arg Ser Arg Arg Leu Arg Lys Leu Leu Glu Leu
                645                 650                 655     
Val Leu Ala Leu Gly Met Ile His Cys Pro Phe Ala Lys His Ser Ile
            660                 665                 670         
Thr Gln Thr Thr Ser Ile Pro Pro Gly Asn Tyr Met Asn Arg Gly Ala
        675                 680                 685             
Arg Gly Asn Ala Ser Gly Phe Arg Leu Ala Ser Leu Asn Arg Leu Ala
    690                 695                 700                 
Asp Thr Lys Ser Ser Ala Ala Lys Gly Thr Thr Leu Leu His Tyr Leu
705                 710                 715                 720 
Val Gln Val Ile Glu Arg Lys Phe Lys Asp Leu Leu Lys Leu Glu Asp
                725                 730                 735     
Asp Ile Pro His Val Arg Glu Ala Ser Lys Val Ser Leu Gly Glu Met
            740                 745                 750         
Asp Lys Asp Ile Gln Met Leu Arg Thr Gly Leu Ala Asp Val Ala Arg
        755                 760                 765             
Glu Ile Glu Phe His Arg Ser Ser Gly Pro Ala Gln Gln Gly Asp Arg
    770                 775                 780                 
Phe Leu Pro Val Met Arg Glu Phe His Ala Gln Ala Ser Val Arg Phe
785                 790                 795                 800 
Ala Glu Leu Glu Asp Lys Phe Gln Asp Met Lys Thr Arg Phe Asp Arg
                805                 810                 815     
Ala Val Arg Leu Phe Gly Glu Asp Gly Ser Val Leu Gln Pro Asp Glu
            820                 825                 830         
Phe Phe Gly Ile Phe Asp Ser Phe Leu Ala Ala Phe Ala Glu Ala Arg
        835                 840                 845             
His Asp Asn Glu Ser Phe Arg Arg Arg Gln Glu Glu Glu Glu Lys Arg
    850                 855                 860                 
Ala Lys Gln Glu Ala Glu Leu Lys Lys Arg Thr Ile Glu Arg Lys Asn
865                 870                 875                 880 
Lys Thr Gly Leu Met Thr Ser Val Ala Arg Asn Leu Gly Leu Lys Ser
                885                 890                 895     
Gly Ser Ser Asn Gly Asp Pro Asp Ser Pro Ala Lys Gly Gly Asp Asn
            900                 905                 910         
Lys Gly Glu Phe Asp Asp Leu Ile Ser Ala Leu Arg Thr Gly Asp Val
        915                 920                 925             
Phe Gly Glu Asp Met Ala Lys Phe Lys Arg Ser Arg Lys Ala Arg Val
    930                 935                 940                 
Leu Asn Gly Gly Gly Ser Ser Thr Gly His Thr Ser Pro Pro Arg His
945                 950                 955                 960 
Gly Ser Leu Gln Arg Glu Glu Ser Gly Arg Glu Arg Glu Arg Thr Val
                965                 970                 975     
Arg Arg Gln
            


<210> 338
<211> 426
<212> PRT
<213> Homo sapiens

<400> 338
Phe Asn Asn His Gly Leu Gln Val Gln Gln Gln Gln Gln Arg Asn Leu
 1               5                  10                  15      
Ser Leu His Glu Tyr Met Ser Met Glu Leu Leu Gln Glu Ala Gly Val
            20                  25                  30          
Ser Val Pro Lys Gly Tyr Val Ala Lys Ser Pro Asp Glu Ala Tyr Ala
        35                  40                  45              
Ile Ala Lys Lys Leu Gly Ser Lys Asp Val Val Ile Lys Ala Gln Val
    50                  55                  60                  
Leu Ala Gly Gly Arg Gly Lys Gly Thr Phe Glu Ser Gly Leu Lys Gly
65                  70                  75                  80  
Gly Val Lys Ile Val Phe Ser Pro Glu Glu Ala Lys Ala Val Ser Ser
                85                  90                  95      
Gln Met Ile Gly Lys Lys Leu Phe Thr Lys Gln Thr Gly Glu Lys Gly
            100                 105                 110         
Arg Ile Cys Asn Gln Val Leu Val Cys Glu Arg Lys Tyr Pro Arg Arg
        115                 120                 125             
Glu Tyr Tyr Phe Ala Ile Thr Met Glu Arg Ser Phe Gln Gly Pro Val
    130                 135                 140                 
Leu Ile Gly Ser Ser His Gly Gly Val Asn Ile Glu Asp Val Ala Ala
145                 150                 155                 160 
Glu Thr Pro Glu Ala Ile Ile Lys Glu Pro Ile Asp Ile Glu Glu Gly
                165                 170                 175     
Ile Lys Lys Glu Gln Ala Leu Gln Leu Ala Gln Lys Met Gly Phe Pro
            180                 185                 190         
Pro Asn Ile Val Glu Ser Ala Ala Glu Asn Met Val Lys Leu Tyr Ser
        195                 200                 205             
Leu Phe Leu Lys Tyr Asp Ala Thr Met Ile Glu Ile Asn Pro Met Val
    210                 215                 220                 
Glu Asp Ser Asp Gly Ala Val Leu Cys Met Asp Ala Lys Ile Asn Phe
225                 230                 235                 240 
Asp Ser Asn Ser Ala Tyr Arg Gln Lys Lys Ile Phe Asp Leu Gln Asp
                245                 250                 255     
Trp Thr Gln Glu Asp Glu Arg Asp Lys Asp Ala Ala Lys Ala Asn Leu
            260                 265                 270         
Asn Tyr Ile Gly Leu Asp Gly Asn Ile Gly Cys Leu Val Asn Gly Ala
        275                 280                 285             
Gly Leu Ala Met Ala Thr Met Asp Ile Ile Lys Leu His Gly Gly Thr
    290                 295                 300                 
Pro Ala Asn Phe Leu Asp Val Gly Gly Gly Ala Thr Val His Gln Val
305                 310                 315                 320 
Thr Glu Ala Phe Lys Leu Ile Thr Ser Asp Lys Lys Val Leu Ala Ile
                325                 330                 335     
Leu Val Asn Ile Phe Gly Gly Ile Met Arg Cys Asp Val Ile Ala Gln
            340                 345                 350         
Gly Ile Val Met Ala Val Lys Asp Leu Glu Ile Lys Ile Pro Val Val
        355                 360                 365             
Val Arg Leu Gln Gly Thr Arg Val Asp Asp Ala Lys Ala Leu Ile Ala
    370                 375                 380                 
Asp Ser Gly Leu Lys Ile Leu Ala Cys Asp Asp Leu Asp Glu Ala Ala
385                 390                 395                 400 
Arg Met Val Val Lys Leu Ser Glu Ile Val Thr Leu Ala Lys Gln Ala
                405                 410                 415     
His Val Asp Val Lys Phe Gln Leu Pro Ile
            420                 425     


<210> 339
<211> 426
<212> PRT
<213> Homo sapiens

<400> 339
Phe Asn Asn His Gly Leu Gln Val Gln Gln Gln Gln Gln Arg Asn Leu
 1               5                  10                  15      
Ser Leu His Glu Tyr Met Ser Met Glu Leu Leu Gln Glu Ala Gly Val
            20                  25                  30          
Ser Val Pro Lys Gly Tyr Val Ala Lys Ser Pro Asp Glu Ala Tyr Ala
        35                  40                  45              
Ile Ala Lys Lys Leu Gly Ser Lys Asp Val Val Ile Lys Ala Gln Val
    50                  55                  60                  
Leu Ala Gly Gly Arg Gly Lys Gly Thr Phe Glu Ser Gly Leu Lys Gly
65                  70                  75                  80  
Gly Val Lys Ile Val Phe Ser Pro Glu Glu Ala Lys Ala Val Ser Ser
                85                  90                  95      
Gln Met Ile Gly Lys Lys Leu Phe Thr Lys Gln Thr Gly Glu Lys Gly
            100                 105                 110         
Arg Ile Cys Asn Gln Val Leu Val Cys Glu Arg Lys Tyr Pro Arg Arg
        115                 120                 125             
Glu Tyr Tyr Phe Ala Ile Thr Met Glu Arg Ser Phe Gln Gly Pro Val
    130                 135                 140                 
Leu Ile Gly Ser Ser His Gly Gly Val Asn Ile Glu Asp Val Ala Ala
145                 150                 155                 160 
Glu Thr Pro Glu Ala Ile Ile Lys Glu Pro Ile Asp Ile Glu Glu Gly
                165                 170                 175     
Ile Lys Lys Glu Gln Ala Leu Gln Leu Ala Gln Lys Met Gly Phe Pro
            180                 185                 190         
Pro Asn Ile Val Glu Ser Ala Ala Glu Asn Met Val Lys Leu Tyr Ser
        195                 200                 205             
Leu Phe Leu Lys Tyr Asp Ala Thr Met Ile Glu Ile Asn Pro Met Val
    210                 215                 220                 
Glu Asp Ser Asp Gly Ala Val Leu Cys Met Asp Ala Lys Ile Asn Phe
225                 230                 235                 240 
Asp Ser Asn Ser Ala Tyr Arg Gln Lys Lys Ile Phe Asp Leu Gln Asp
                245                 250                 255     
Trp Thr Gln Glu Asp Glu Arg Asp Lys Asp Ala Ala Lys Ala Asn Leu
            260                 265                 270         
Asn Tyr Ile Gly Leu Asp Gly Asn Ile Gly Cys Leu Val Asn Gly Ala
        275                 280                 285             
Gly Leu Ala Met Ala Thr Met Asp Ile Ile Lys Leu His Gly Gly Thr
    290                 295                 300                 
Pro Ala Asn Phe Leu Asp Val Gly Gly Gly Ala Thr Val His Gln Val
305                 310                 315                 320 
Thr Glu Ala Phe Lys Leu Ile Thr Ser Asp Lys Lys Val Leu Ala Ile
                325                 330                 335     
Leu Val Asn Ile Phe Gly Gly Ile Met Arg Cys Asp Val Ile Ala Gln
            340                 345                 350         
Gly Ile Val Met Ala Val Lys Asp Leu Glu Ile Lys Ile Pro Val Val
        355                 360                 365             
Val Arg Leu Gln Gly Thr Arg Val Asp Asp Ala Lys Ala Leu Ile Ala
    370                 375                 380                 
Asp Ser Gly Leu Lys Ile Leu Ala Cys Asp Asp Leu Asp Glu Ala Ala
385                 390                 395                 400 
Arg Met Val Val Lys Leu Ser Glu Ile Val Thr Leu Ala Lys Gln Ala
                405                 410                 415     
His Val Asp Val Lys Phe Gln Leu Pro Ile
            420                 425     


<210> 340
<211> 404
<212> PRT
<213> Homo sapiens

<400> 340
Ala Val Gln Leu Thr Ser Arg Arg Trp Leu Asn Leu Gln Glu Tyr Gln
 1               5                  10                  15      
Ser Lys Lys Leu Met Ser Asp Asn Gly Val Arg Val Gln Arg Phe Phe
            20                  25                  30          
Val Ala Asp Thr Ala Asn Glu Ala Leu Glu Ala Ala Lys Arg Leu Asn
        35                  40                  45              
Ala Lys Glu Ile Val Leu Lys Ala Gln Ile Leu Ala Gly Gly Arg Gly
    50                  55                  60                  
Lys Gly Val Phe Asn Ser Gly Leu Lys Gly Gly Val His Leu Thr Lys
65                  70                  75                  80  
Asp Pro Asn Val Val Gly Gln Leu Ala Lys Gln Met Ile Gly Tyr Asn
                85                  90                  95      
Leu Ala Thr Lys Gln Thr Pro Lys Glu Gly Val Lys Val Asn Lys Val
            100                 105                 110         
Met Val Ala Glu Ala Leu Asp Ile Ser Arg Glu Thr Tyr Leu Ala Ile
        115                 120                 125             
Leu Met Asp Arg Ser Cys Asn Gly Pro Val Leu Val Gly Ser Pro Gln
    130                 135                 140                 
Gly Arg Ser Asp Ile Glu Glu Val Ala Ala Ser Asn Pro Glu Leu Ile
145                 150                 155                 160 
Phe Lys Glu Gln Ile Asp Ile Phe Glu Gly Ile Lys Asp Ser Gln Ala
                165                 170                 175     
Gln Arg Met Ala Glu Asn Leu Gly Phe Val Gly Pro Leu Lys Ser Gln
            180                 185                 190         
Ala Ala Asp Gln Ile Thr Lys Leu Tyr Asn Leu Phe Leu Lys Ile Asp
        195                 200                 205             
Ala Thr Gln Val Glu Val Asn Pro Phe Gly Glu Thr Pro Glu Gly Gln
    210                 215                 220                 
Val Val Cys Phe Asp Ala Lys Ile Asn Phe Asp Asp Asn Ala Glu Phe
225                 230                 235                 240 
Arg Gln Lys Asp Ile Phe Ala Met Asp Asp Lys Ser Glu Asn Glu Pro
                245                 250                 255     
Ile Glu Asn Glu Ala Ala Lys Tyr Asp Leu Lys Tyr Ile Gly Leu Asp
            260                 265                 270         
Gly Asn Ile Ala Cys Phe Val Asn Gly Ala Gly Leu Ala Met Ala Thr
        275                 280                 285             
Cys Asp Ile Ile Phe Leu Asn Gly Gly Lys Pro Ala Asn Phe Leu Asp
    290                 295                 300                 
Leu Gly Gly Gly Val Lys Glu Ala Gln Val Tyr Gln Ala Phe Lys Leu
305                 310                 315                 320 
Leu Thr Ala Asp Pro Lys Val Glu Ala Ile Leu Val Asn Ile Phe Gly
                325                 330                 335     
Gly Ile Val Asn Cys Ala Ile Ile Ala Asn Gly Ile Thr Lys Ala Cys
            340                 345                 350         
Arg Glu Leu Glu Leu Lys Val Pro Leu Val Val Arg Leu Glu Gly Thr
        355                 360                 365             
Asn Val Gln Glu Ala Gln Lys Ile Leu Asn Asn Ser Gly Leu Pro Ile
    370                 375                 380                 
Thr Ser Ala Ile Asp Leu Glu Asp Ala Ala Lys Lys Ala Val Ala Ser
385                 390                 395                 400 
Val Ala Lys Lys
                


<210> 341
<211> 504
<212> PRT
<213> Homo sapiens

<400> 341
Met Ala Arg Arg Cys Gly Pro Val Ala Leu Leu Leu Gly Phe Gly Leu
 1               5                  10                  15      
Leu Arg Leu Cys Ser Gly Val Trp Gly Ala Asp Thr Glu Glu Arg Leu
            20                  25                  30          
Val Glu His Leu Leu Asp Pro Ser Arg Tyr Asn Lys Leu Ile Arg Pro
        35                  40                  45              
Ala Thr Asn Gly Ser Glu Leu Val Thr Val Gln Leu Met Val Ser Leu
    50                  55                  60                  
Ala Gln Leu Ile Ser Val His Glu Arg Glu Gln Ile Met Thr Thr Asn
65                  70                  75                  80  
Val Trp Leu Thr Gln Glu Trp Glu Asp Tyr Arg Leu Thr Trp Lys Pro
                85                  90                  95      
Glu Glu Phe Asp Asn Met Lys Lys Val Arg Leu Pro Ser Lys His Ile
            100                 105                 110         
Trp Leu Pro Asp Val Val Leu Tyr Asn Asn Ala Asp Gly Met Tyr Glu
        115                 120                 125             
Val Ser Phe Tyr Ser Asn Ala Val Val Ser Tyr Asp Gly Ser Ile Phe
    130                 135                 140                 
Trp Leu Pro Pro Ala Ile Tyr Lys Ser Ala Cys Lys Ile Glu Val Lys
145                 150                 155                 160 
His Phe Pro Phe Asp Gln Gln Asn Cys Thr Met Lys Phe Arg Ser Trp
                165                 170                 175     
Thr Tyr Asp Arg Thr Glu Ile Asp Leu Val Leu Lys Ser Glu Val Ala
            180                 185                 190         
Ser Leu Asp Asp Phe Thr Pro Ser Gly Glu Trp Asp Ile Val Ala Leu
        195                 200                 205             
Pro Gly Arg Arg Asn Glu Asn Pro Asp Asp Ser Thr Tyr Val Asp Ile
    210                 215                 220                 
Thr Tyr Asp Phe Ile Ile Arg Arg Lys Pro Leu Phe Tyr Thr Ile Asn
225                 230                 235                 240 
Leu Ile Ile Pro Cys Val Leu Ile Thr Ser Leu Ala Ile Leu Val Phe
                245                 250                 255     
Tyr Leu Pro Ser Asp Cys Gly Glu Lys Met Thr Leu Cys Ile Ser Val
            260                 265                 270         
Leu Leu Ala Leu Thr Val Phe Leu Leu Leu Ile Ser Lys Ile Val Pro
        275                 280                 285             
Pro Thr Ser Leu Asp Val Pro Leu Val Gly Lys Tyr Leu Met Phe Thr
    290                 295                 300                 
Met Val Leu Val Thr Phe Ser Ile Val Thr Ser Val Cys Val Leu Asn
305                 310                 315                 320 
Val His His Arg Ser Pro Thr Thr His Thr Met Ala Pro Trp Val Lys
                325                 330                 335     
Val Val Phe Leu Glu Lys Leu Pro Ala Leu Leu Phe Met Gln Gln Pro
            340                 345                 350         
Arg His His Cys Ala Arg Gln Arg Leu Arg Leu Arg Arg Arg Gln Arg
        355                 360                 365             
Glu Arg Glu Gly Ala Gly Ala Leu Phe Phe Arg Glu Ala Pro Gly Ala
    370                 375                 380                 
Asp Ser Cys Thr Cys Phe Val Asn Arg Ala Ser Val Gln Gly Leu Ala
385                 390                 395                 400 
Gly Ala Phe Gly Ala Glu Pro Ala Pro Val Ala Gly Pro Gly Arg Ser
                405                 410                 415     
Gly Glu Pro Cys Gly Cys Gly Leu Arg Ala Ala Val Asp Gly Val Arg
            420                 425                 430         
Phe Ile Ala Asp His Met Arg Ser Glu Asp Asp Asp Gln Ser Val Arg
        435                 440                 445             
Val Ser Glu Asp Trp Lys Tyr Val Ala Met Val Ile Asp Arg Leu Phe
    450                 455                 460                 
Leu Trp Ile Phe Val Phe Val Cys Val Phe Gly Thr Ile Gly Met Phe
465                 470                 475                 480 
Leu Gln Pro Leu Phe Gln Asn Tyr Thr Thr Thr Thr Phe Leu His Ser
                485                 490                 495     
Asp His Ser Ala Pro Ser Ser Lys
            500                 


<210> 342
<211> 945
<212> PRT
<213> Homo sapiens

<400> 342
Ala Ser Asp Arg Ala Glu Gly Arg Pro Ala Lys Pro Ser Lys Thr Ala
 1               5                  10                  15      
Ala Arg Glu Lys Thr Glu Gly Ala Val Ala Ala Val Gly Gly Gly Pro
            20                  25                  30          
Ser Ser Phe Arg Cys Cys Tyr Gly Cys Cys His Glu Ala Arg Leu Gly
        35                  40                  45              
Arg Thr Ser Leu Pro Arg Gly Val Ile Met Leu Thr Glu Ala Ser Leu
    50                  55                  60                  
Ser Ile Trp Gly Trp Gly Ser Leu Gly Ile Val Leu Phe Leu Ile Thr
65                  70                  75                  80  
Phe Gly Pro Phe Val Ile Phe Tyr Leu Thr Phe Tyr Ile Leu Cys Phe
                85                  90                  95      
Val Gly Gly Gly Leu Val Val Thr Leu Leu Phe Gly Lys Thr Asn Ser
            100                 105                 110         
Glu Lys Tyr Leu Glu Gln Cys Glu His Ser Phe Leu Pro Pro Thr Ser
        115                 120                 125             
Pro Gly Val Pro Lys Cys Leu Glu Glu Met Lys Arg Glu Ala Arg Thr
    130                 135                 140                 
Ile Lys Ile Asp Arg Arg Leu Thr Gly Ala Asn Ile Ile Asp Glu Pro
145                 150                 155                 160 
Leu Gln Gln Val Ile Gln Phe Ser Leu Arg Asp Tyr Val Gln Tyr Trp
                165                 170                 175     
Tyr Tyr Thr Leu Ser Asp Asp Glu Ser Phe Leu Leu Glu Ile Arg Gln
            180                 185                 190         
Thr Leu Gln Asn Ala Leu Ile Gln Phe Ala Thr Arg Ser Lys Glu Ile
        195                 200                 205             
Asp Trp Gln Pro Tyr Phe Thr Thr Arg Ile Val Asp Asp Phe Gly Thr
    210                 215                 220                 
His Leu Arg Val Phe Arg Lys Ala Gln Gln Lys Ile Thr Glu Lys Asp
225                 230                 235                 240 
Asp Gln Val Lys Gly Thr Ala Glu Asp Leu Val Asp Thr Phe Phe Glu
                245                 250                 255     
Val Glu Val Glu Met Glu Lys Glu Val Cys Arg Asp Leu Val Cys Thr
            260                 265                 270         
Ser Pro Lys Asp Glu Glu Gly Phe Leu Arg Asp Leu Cys Glu Val Leu
        275                 280                 285             
Leu Tyr Leu Leu Leu Pro Pro Gly Asp Phe Gln Asn Lys Ile Met Arg
    290                 295                 300                 
Tyr Phe Val Arg Glu Ile Leu Ala Arg Gly Ile Leu Leu Pro Leu Ile
305                 310                 315                 320 
Asn Gln Leu Ser Asp Pro Asp Tyr Ile Asn Gln Tyr Val Ile Trp Met
                325                 330                 335     
Ile Arg Asp Ser Asn Cys Asn Tyr Glu Ala Phe Met Asn Ile Ile Lys
            340                 345                 350         
Leu Ser Asp Asn Ile Gly Glu Leu Glu Ala Val Arg Asp Lys Ala Ala
        355                 360                 365             
Glu Glu Leu Gln Tyr Leu Arg Ser Leu Asp Thr Ala Gly Asp Asp Ile
    370                 375                 380                 
Asn Thr Ile Lys Asn Gln Ile Asn Ser Leu Leu Phe Val Lys Lys Val
385                 390                 395                 400 
Cys Asp Ser Arg Ile Gln Arg Leu Gln Ser Gly Lys Glu Ile Asn Thr
                405                 410                 415     
Val Lys Leu Ala Ala Asn Phe Gly Lys Leu Cys Thr Val Pro Leu Asp
            420                 425                 430         
Ser Ile Leu Val Asp Asn Val Ala Leu Gln Phe Phe Met Asp Tyr Met
        435                 440                 445             
Gln Gln Thr Gly Gly Gln Ala His Leu Phe Phe Trp Met Thr Val Glu
    450                 455                 460                 
Gly Tyr Arg Val Thr Ala Gln Gln Gln Leu Glu Val Leu Leu Ser Arg
465                 470                 475                 480 
Gln Arg Asp Gly Lys His Gln Thr Asn Gln Thr Lys Gly Leu Leu Arg
                485                 490                 495     
Ala Ala Ala Val Gly Ile Tyr Glu Gln Tyr Leu Ser Glu Lys Ala Ser
            500                 505                 510         
Pro Arg Val Thr Val Asp Asp Tyr Leu Val Ala Lys Leu Ala Asp Thr
        515                 520                 525             
Leu Asn His Glu Asp Pro Thr Pro Glu Ile Phe Asp Asp Ile Gln Arg
    530                 535                 540                 
Lys Val Tyr Glu Leu Met Leu Arg Asp Glu Arg Phe Tyr Pro Ser Phe
545                 550                 555                 560 
Arg Gln Asn Ala Leu Tyr Val Arg Met Leu Ala Glu Leu Asp Met Leu
                565                 570                 575     
Lys Asp Pro Ser Phe Arg Gly Ser Asp Asp Gly Asp Gly Glu Ser Phe
            580                 585                 590         
Asn Gly Ser Pro Thr Gly Ser Ile Asn Leu Ser Leu Asp Asp Leu Ser
        595                 600                 605             
Asn Val Ser Ser Asp Asp Ser Val Gln Leu His Ala Tyr Ile Ser Asp
    610                 615                 620                 
Thr Val Tyr Ala Asp Tyr Asp Pro Tyr Ala Val Ala Gly Val Cys Asn
625                 630                 635                 640 
Asp His Gly Lys Thr Tyr Ala Leu Tyr Ala Ile Thr Val His Arg Arg
                645                 650                 655     
Asn Leu Asn Ser Glu Glu Met Trp Lys Thr Tyr Arg Arg Tyr Ser Asp
            660                 665                 670         
Phe His Asp Phe His Met Arg Ile Thr Glu Gln Phe Glu Ser Leu Ser
        675                 680                 685             
Ser Ile Leu Lys Leu Pro Glu Lys Lys Thr Phe Asn Asn Met Asp Arg
    690                 695                 700                 
Asp Phe Leu Glu Lys Arg Lys Lys Asp Leu Asn Ala Tyr Leu Gln Leu
705                 710                 715                 720 
Leu Leu Ala Pro Glu Met Met Lys Ala Ser Pro Ala Leu Ala His Tyr
                725                 730                 735     
Val Tyr Asp Phe Leu Glu Asn Lys Ala Tyr Ser Lys Gly Lys Gly Asp
            740                 745                 750         
Phe Ala Arg Lys Met Asp Thr Phe Val Asn Pro Leu Arg Asn Ser Met
        755                 760                 765             
Arg Asn Val Ser Asn Ala Val Lys Ser Leu Pro Asp Ser Leu Ala Glu
    770                 775                 780                 
Gly Met Thr Lys Met Ser Asp Asn Met Gly Lys Met Ser Glu Arg Leu
785                 790                 795                 800 
Gly Gln Asp Ile Lys Gln Ser Phe Phe Lys Val Pro Pro Leu Ile Pro
                805                 810                 815     
Lys Thr Asp Ser Asp Pro Glu His Arg Arg Val Ser Ala Gln Leu Asp
            820                 825                 830         
Asp Asn Val Asp Asp Asn Ile Pro Leu Arg Val Met Leu Leu Leu Met
        835                 840                 845             
Asp Glu Val Phe Asp Leu Lys Glu Arg Asn Gln Trp Leu Arg Arg Asn
    850                 855                 860                 
Ile Lys Asn Leu Leu Gln Gln Leu Ile Arg Ala Thr Tyr Gly Asp Thr
865                 870                 875                 880 
Ile Asn Arg Lys Ile Val Asp His Val Asp Trp Met Thr Ser Pro Glu
                885                 890                 895     
Gln Val Ala Asp Ser Val Lys Arg Phe Arg Asp Ala Phe Trp Pro Asn
            900                 905                 910         
Gly Ile Leu Ala Glu Ala Val Pro Cys Arg Asp Lys Ser Ile Arg Met
        915                 920                 925             
Arg Thr Arg Val Ala Gly Lys Thr Lys Leu Leu Ala Ile Met Pro Gly
    930                 935                 940                 
Glu
945 


<210> 343
<211> 1319
<212> PRT
<213> Homo sapiens

<400> 343
Ser Cys Gln Ser Arg Ser Pro Trp Pro Pro Arg Pro Glu Val Arg Ala
 1               5                  10                  15      
Pro Ala Lys Gly Pro Arg Gly Val Ala Gly Ala Ala Gly Ala Cys Ser
            20                  25                  30          
Ala Gly Ala Arg Leu Gly Asp Ala Ala Gly Gly Asp Pro Ala Ser Gly
        35                  40                  45              
Gln Ala Ala Arg Gly Cys Gly Ala Arg Ala Pro Arg Gly Leu Gly Arg
    50                  55                  60                  
Thr Ala Arg Ala Arg Asp Thr Ala Met Glu Asp Ala Gly Ala Ala Gly
65                  70                  75                  80  
Pro Gly Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Ala
                85                  90                  95      
Pro Glu Pro Glu Pro Glu Pro Lys Pro Gly Ala Gly Thr Ser Glu Ala
            100                 105                 110         
Phe Ser Arg Leu Trp Thr Asp Val Met Gly Ile Leu Asp Gly Ser Leu
        115                 120                 125             
Gly Asn Ile Asp Asp Leu Ala Gln Gln Tyr Ala Asp Tyr Tyr Asn Thr
    130                 135                 140                 
Cys Phe Ser Asp Val Cys Glu Arg Met Glu Glu Leu Arg Lys Arg Arg
145                 150                 155                 160 
Val Ser Gln Asp Leu Glu Val Glu Lys Pro Asp Ala Ser Pro Thr Ser
                165                 170                 175     
Leu Gln Leu Arg Ser Gln Ile Glu Glu Ser Leu Gly Phe Cys Ser Ala
            180                 185                 190         
Val Ser Thr Pro Glu Val Glu Arg Lys Asn Pro Leu His Lys Ser Asn
        195                 200                 205             
Ser Glu Asp Ser Ser Val Gly Lys Gly Asp Trp Lys Lys Lys Asn Lys
    210                 215                 220                 
Tyr Phe Trp Gln Asn Phe Arg Lys Asn Gln Lys Gly Ile Met Arg Gln
225                 230                 235                 240 
Thr Ser Lys Gly Glu Asp Val Gly Tyr Val Ala Ser Glu Ile Thr Met
                245                 250                 255     
Ser Asp Glu Glu Arg Ile Gln Leu Met Met Met Val Lys Glu Lys Met
            260                 265                 270         
Ile Thr Ile Glu Glu Ala Leu Ala Arg Leu Lys Glu Tyr Glu Ala Gln
        275                 280                 285             
His Arg Gln Ser Ala Ala Leu Asp Pro Ala Asp Trp Pro Asp Gly Ser
    290                 295                 300                 
Tyr Pro Thr Phe Asp Gly Ser Ser Asn Cys Asn Ser Arg Glu Gln Ser
305                 310                 315                 320 
Asp Asp Glu Thr Glu Glu Ser Val Lys Phe Lys Arg Leu His Lys Leu
                325                 330                 335     
Val Asn Ser Thr Arg Arg Val Arg Lys Lys Leu Ile Arg Val Glu Glu
            340                 345                 350         
Met Lys Lys Pro Ser Thr Glu Gly Gly Glu Glu His Val Phe Glu Asn
        355                 360                 365             
Ser Pro Val Leu Asp Glu Arg Ser Ala Leu Tyr Ser Gly Val His Lys
    370                 375                 380                 
Lys Pro Leu Phe Phe Asp Gly Ser Pro Glu Lys Pro Pro Glu Asp Asp
385                 390                 395                 400 
Ser Asp Ser Leu Thr Thr Ser Pro Ser Ser Ser Ser Leu Asp Thr Trp
                405                 410                 415     
Gly Ala Gly Arg Lys Leu Val Lys Thr Phe Ser Lys Gly Glu Ser Arg
            420                 425                 430         
Gly Leu Ile Lys Pro Pro Lys Lys Met Gly Thr Phe Phe Ser Tyr Pro
        435                 440                 445             
Glu Glu Glu Lys Ala Gln Lys Val Ser Arg Ser Leu Thr Glu Gly Glu
    450                 455                 460                 
Met Lys Lys Gly Leu Gly Ser Leu Ser His Gly Arg Thr Cys Ser Phe
465                 470                 475                 480 
Gly Gly Phe Asp Leu Thr Asn Arg Ser Leu His Val Gly Ser Asn Asn
                485                 490                 495     
Ser Asp Pro Met Gly Lys Glu Gly Asp Phe Val Tyr Lys Glu Val Ile
            500                 505                 510         
Lys Ser Pro Thr Ala Ser Arg Ile Ser Leu Gly Lys Lys Val Lys Ser
        515                 520                 525             
Val Lys Glu Thr Met Arg Lys Arg Met Ser Lys Lys Tyr Ser Ser Ser
    530                 535                 540                 
Val Ser Glu Gln Asp Ser Gly Leu Asp Gly Met Pro Gly Ser Pro Pro
545                 550                 555                 560 
Pro Ser Gln Pro Asp Pro Glu His Leu Asp Lys Pro Lys Leu Lys Ala
                565                 570                 575     
Gly Gly Ser Val Glu Ser Leu Arg Ser Ser Leu Ser Gly Gln Ser Ser
            580                 585                 590         
Met Ser Gly Gln Thr Val Ser Thr Thr Asp Ser Ser Thr Ser Asn Arg
        595                 600                 605             
Glu Ser Val Lys Ser Glu Asp Gly Asp Asp Glu Glu Pro Pro Tyr Arg
    610                 615                 620                 
Gly Pro Phe Cys Gly Arg Ala Arg Val His Thr Asp Phe Thr Pro Ser
625                 630                 635                 640 
Pro Tyr Asp Thr Asp Ser Leu Lys Leu Lys Lys Gly Asp Ile Ile Asp
                645                 650                 655     
Ile Ile Ser Lys Pro Pro Met Gly Thr Trp Met Gly Leu Leu Asn Asn
            660                 665                 670         
Lys Val Gly Thr Phe Lys Phe Ile Tyr Val Asp Val Leu Ser Glu Asp
        675                 680                 685             
Glu Glu Lys Pro Lys Arg Pro Thr Arg Arg Arg Arg Lys Gly Arg Pro
    690                 695                 700                 
Pro Gln Pro Lys Ser Val Glu Asp Leu Leu Asp Arg Ile Asn Leu Lys
705                 710                 715                 720 
Glu His Met Pro Thr Phe Leu Phe Asn Gly Tyr Glu Asp Leu Asp Thr
                725                 730                 735     
Phe Lys Leu Leu Glu Glu Glu Asp Leu Asp Glu Leu Asn Ile Arg Asp
            740                 745                 750         
Pro Glu His Arg Ala Val Leu Leu Thr Ala Val Glu Leu Leu Gln Glu
        755                 760                 765             
Tyr Asp Ser Asn Ser Asp Gln Ser Gly Ser Gln Glu Lys Leu Leu Val
    770                 775                 780                 
Asp Ser Gln Gly Leu Ser Gly Cys Ser Pro Arg Asp Ser Gly Cys Tyr
785                 790                 795                 800 
Glu Ser Ser Glu Asn Leu Glu Asn Gly Lys Thr Arg Lys Ala Ser Leu
                805                 810                 815     
Leu Ser Ala Lys Ser Ser Thr Glu Pro Ser Leu Lys Ser Phe Ser Arg
            820                 825                 830         
Asn Gln Leu Gly Asn Tyr Pro Thr Leu Pro Leu Met Lys Ser Gly Asp
        835                 840                 845             
Ala Leu Lys Gln Gly Gln Glu Glu Gly Arg Leu Gly Gly Gly Leu Ala
    850                 855                 860                 
Pro Asp Thr Ser Lys Ser Cys Asp Pro Pro Gly Val Thr Gly Leu Asn
865                 870                 875                 880 
Lys Asn Arg Arg Ser Leu Pro Val Ser Ile Cys Arg Ser Cys Glu Thr
                885                 890                 895     
Leu Glu Gly Pro Gln Thr Val Asp Thr Trp Pro Arg Ser His Ser Leu
            900                 905                 910         
Asp Asp Leu Gln Val Glu Pro Gly Ala Glu Gln Asp Val Pro Thr Glu
        915                 920                 925             
Val Thr Glu Pro Pro Pro Gln Ile Val Pro Glu Val Pro Gln Lys Thr
    930                 935                 940                 
Thr Ala Ser Ser Thr Lys Ala Gln Pro Leu Glu Arg Asp Ser Ala Val
945                 950                 955                 960 
Asp Asn Ala Leu Leu Leu Thr Gln Ser Lys Arg Phe Ser Glu Pro Gln
                965                 970                 975     
Lys Leu Thr Thr Lys Lys Leu Glu Gly Ser Ile Ala Ala Ser Gly Arg
            980                 985                 990         
Gly Leu Ser Pro Pro Gln Cys Leu Pro Arg Asn Tyr Asp Ala Gln Pro
        995                 1000                1005            
Pro Gly Ala Lys His Gly Leu Ala Arg Thr Pro Leu Glu Gly His Arg
    1010                1015                1020                
Lys Gly His Glu Phe Glu Gly Thr His His Pro Leu Gly Thr Lys Glu
1025                1030                1035                1040
Gly Val Asp Ala Glu Gln Arg Met Gln Pro Lys Ile Pro Ser Gln Pro
                1045                1050                1055    
Pro Pro Val Pro Ala Lys Lys Ser Arg Glu Arg Leu Ala Asn Gly Leu
            1060                1065                1070        
His Pro Val Pro Met Gly Pro Ser Gly Ala Leu Pro Ser Pro Asp Ala
        1075                1080                1085            
Pro Cys Leu Pro Val Lys Arg Gly Ser Pro Ala Ser Pro Thr Ser Pro
    1090                1095                1100                
Ser Asp Cys Pro Pro Ala Leu Ala Pro Arg Pro Leu Ser Gly Gln Ala
1105                1110                1115                1120
Pro Gly Ser Pro Pro Ser Thr Arg Pro Pro Pro Trp Leu Ser Glu Leu
                1125                1130                1135    
Pro Glu Asn Thr Ser Leu Gln Glu His Gly Val Lys Leu Gly Pro Ala
            1140                1145                1150        
Leu Thr Arg Lys Val Ser Cys Ala Arg Gly Val Asp Leu Glu Thr Leu
        1155                1160                1165            
Thr Glu Asn Lys Leu His Ala Glu Gly Ile Asp Leu Thr Glu Glu Pro
    1170                1175                1180                
Tyr Ser Asp Lys His Gly Arg Cys Gly Ile Pro Glu Ala Leu Val Gln
1185                1190                1195                1200
Arg Tyr Ala Glu Asp Leu Asp Gln Pro Glu Arg Asp Val Ala Ala Asn
                1205                1210                1215    
Met Asp Gln Ile Arg Val Lys Gln Leu Arg Lys Gln His Arg Met Ala
            1220                1225                1230        
Ile Pro Ser Gly Gly Leu Thr Glu Ile Cys Arg Lys Pro Val Ser Pro
        1235                1240                1245            
Gly Cys Ile Ser Ser Val Ser Asp Trp Leu Ile Ser Ile Gly Leu Pro
    1250                1255                1260                
Met Tyr Ala Gly Thr Leu Ser Thr Ala Gly Phe Ser Thr Leu Ser Gln
1265                1270                1275                1280
Val Pro Ser Leu Ser His Thr Cys Leu Gln Glu Ala Gly Ile Thr Glu
                1285                1290                1295    
Glu Arg His Ile Arg Lys Leu Leu Ser Ala Ala Arg Leu Phe Lys Leu
            1300                1305                1310        
Pro Pro Gly Pro Glu Ala Met
        1315                


<210> 344
<211> 198
<212> PRT
<213> Homo sapiens

<400> 344
Met Glu Gly Gly Leu Gly Arg Ala Val Cys Leu Leu Thr Gly Ala Ser
 1               5                  10                  15      
Arg Gly Phe Gly Arg Thr Leu Ala Pro Leu Leu Ala Ser Leu Leu Ser
            20                  25                  30          
Pro Gly Ser Val Leu Val Leu Ser Ala Arg Asn Asp Glu Ala Leu Arg
        35                  40                  45              
Gln Leu Glu Ala Glu Leu Gly Ala Glu Arg Ser Gly Leu Arg Val Val
    50                  55                  60                  
Arg Val Pro Ala Asp Leu Gly Ala Glu Ala Gly Leu Gln Gln Leu Leu
65                  70                  75                  80  
Gly Ala Leu Arg Glu Leu Pro Arg Pro Lys Gly Leu Gln Arg Leu Leu
                85                  90                  95      
Leu Ile Asn Asn Ala Gly Ser Leu Gly Asp Val Ser Lys Gly Phe Val
            100                 105                 110         
Asp Leu Ser Asp Ser Thr Gln Val Asn Asn Tyr Trp Ala Leu Asn Leu
        115                 120                 125             
Thr Ser Met Leu Cys Leu Thr Ser Ser Val Leu Lys Ala Phe Pro Asp
    130                 135                 140                 
Ser Pro Gly Leu Asn Arg Thr Val Val Asn Ile Ser Ser Leu Cys Ala
145                 150                 155                 160 
Leu Gln Pro Phe Lys Gly Trp Ala Leu Tyr Cys Ala Gly Lys Ala Ala
                165                 170                 175     
Arg Asp Met Leu Phe Gln Val Leu Ala Leu Glu Glu Pro Asn Val Arg
            180                 185                 190         
Val Leu Asn Tyr Ala Pro
        195             


<210> 345
<211> 224
<212> PRT
<213> Homo sapiens

<400> 345
Ile Ile Gly Gly Arg Glu Ser Arg Pro His Ser Arg Pro Tyr Met Ala
 1               5                  10                  15      
Tyr Leu Gln Ile Gln Ser Pro Ala Gly Gln Ser Arg Cys Gly Gly Phe
            20                  25                  30          
Leu Val Arg Glu Asp Phe Val Leu Thr Ala Ala His Cys Trp Gly Ser
        35                  40                  45              
Asn Ile Asn Val Thr Leu Gly Ala His Asn Ile Gln Arg Arg Glu Asn
    50                  55                  60                  
Thr Gln Gln His Ile Thr Ala Arg Arg Ala Ile Arg His Pro Gln Tyr
65                  70                  75                  80  
Asn Gln Arg Thr Ile Gln Asn Asp Ile Met Leu Leu Gln Leu Ser Arg
                85                  90                  95      
Arg Val Arg Arg Asn Arg Asn Val Asn Pro Val Ala Leu Pro Arg Ala
            100                 105                 110         
Gln Glu Gly Leu Arg Pro Gly Thr Leu Cys Thr Val Ala Gly Trp Gly
        115                 120                 125             
Arg Val Ser Met Arg Arg Gly Thr Asp Thr Leu Arg Glu Val Gln Leu
    130                 135                 140                 
Arg Val Gln Arg Asp Arg Gln Cys Leu Arg Ile Phe Gly Ser Tyr Asp
145                 150                 155                 160 
Pro Arg Arg Gln Ile Cys Val Gly Asp Arg Arg Glu Arg Lys Ala Ala
                165                 170                 175     
Phe Lys Gly Asp Ser Gly Gly Pro Leu Leu Cys Asn Asn Val Ala His
            180                 185                 190         
Gly Ile Val Ser Tyr Gly Lys Ser Ser Gly Val Pro Pro Glu Val Phe
        195                 200                 205             
Thr Arg Val Ser Ser Phe Leu Pro Trp Ile Arg Thr Thr Met Arg Ser
    210                 215                 220                 


<210> 346
<211> 54
<212> PRT
<213> Homo sapiens

<400> 346
Ser Arg Gly Gln Arg Arg Lys Val Ala Gln Glu Asn Pro Lys Met His
 1               5                  10                  15      
Asn Ser Lys Ile Ser Lys Arg Leu Gly Ala Glu Trp Lys Leu Leu Ser
            20                  25                  30          
Glu Ala Glu Lys Arg Pro Tyr Ile Asp Glu Ala Lys Arg Leu Arg Ala
        35                  40                  45              
Gln His Met Asn Ala Ala
    50                  


<210> 347
<211> 352
<212> PRT
<213> Homo sapiens

<400> 347
Met Ala Ser Arg Lys Glu Gly Thr Gly Ser Thr Ala Thr Ser Ser Ser
 1               5                  10                  15      
Ser Thr Ala Gly Ala Ala Gly Lys Gly Lys Gly Lys Gly Gly Ser Gly
            20                  25                  30          
Asp Ser Ala Val Lys Gln Val Gln Ile Asp Gly Leu Val Val Leu Lys
        35                  40                  45              
Ile Ile Lys His Tyr Gln Glu Glu Gly Gln Gly Thr Glu Val Val Gln
    50                  55                  60                  
Gly Val Leu Leu Gly Leu Val Val Lys Asp Arg Leu Glu Ile Thr Asn
65                  70                  75                  80  
Cys Phe Pro Phe Pro Gln His Thr Glu Asp Asp Ala Asp Phe Asp Glu
                85                  90                  95      
Val Gln Tyr Gln Met Glu Met Met Arg Ser Leu Arg His Val Asn Ile
            100                 105                 110         
Asp His Leu His Val Gly Trp Tyr Gln Ser Thr Tyr Tyr Gly Ser Phe
        115                 120                 125             
Val Thr Arg Ala Leu Leu Asp Ser Gln Phe Ser Tyr Gln His Ala Ile
    130                 135                 140                 
Glu Glu Ser Val Val Leu Ile Tyr Asp Pro Ile Lys Thr Ala Gln Gly
145                 150                 155                 160 
Ser Leu Ser Leu Lys Ala Tyr Arg Leu Thr Pro Lys Leu Met Glu Val
                165                 170                 175     
Cys Lys Glu Lys Asp Phe Ser Pro Glu Ala Leu Lys Lys Ala Asn Ile
            180                 185                 190         
Thr Phe Glu Tyr Met Phe Glu Glu Val Pro Ile Val Ile Lys Asn Ser
        195                 200                 205             
His Leu Ile Asn Val Leu Met Trp Glu Leu Glu Lys Lys Ser Ala Val
    210                 215                 220                 
Ala Asp Lys His Glu Leu Leu Ser Leu Ala Ser Ser Asn His Leu Gly
225                 230                 235                 240 
Lys Asn Leu Gln Leu Leu Met Asp Arg Val Asp Glu Met Ser Gln Asp
                245                 250                 255     
Ile Val Lys Tyr Asn Thr Tyr Met Arg Asn Thr Ser Lys Gln Gln Gln
            260                 265                 270         
Gln Lys His Gln Tyr Gln Gln Arg Arg Gln Gln Glu Asn Met Gln Arg
        275                 280                 285             
Gln Ser Arg Gly Glu Pro Pro Leu Pro Glu Glu Asp Leu Ser Lys Leu
    290                 295                 300                 
Phe Lys Pro Pro Gln Pro Pro Ala Arg Met Asp Ser Leu Leu Ile Ala
305                 310                 315                 320 
Gly Gln Ile Asn Thr Tyr Cys Gln Asn Ile Lys Glu Phe Thr Ala Gln
                325                 330                 335     
Asn Leu Gly Lys Leu Phe Met Ala Gln Ala Leu Gln Glu Tyr Asn Asn
            340                 345                 350         


<210> 348
<211> 99
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 94
<223> Xaa = Any Amino Acid

<400> 348
Ala Gly Gln Ala Phe Arg Lys Phe Leu Pro Leu Phe Asp Arg Val Leu
 1               5                  10                  15      
Val Glu Arg Ser Ala Ala Glu Thr Val Thr Lys Gly Gly Ile Met Leu
            20                  25                  30          
Pro Glu Lys Ser Gln Gly Lys Val Leu Gln Ala Thr Val Val Ala Val
        35                  40                  45              
Gly Ser Gly Ser Lys Gly Lys Gly Gly Glu Ile Gln Pro Val Ser Val
    50                  55                  60                  
Lys Val Gly Asp Lys Val Leu Leu Pro Glu Tyr Gly Gly Thr Lys Val
65                  70                  75                  80  
Val Leu Asp Asp Lys Asp Tyr Phe Leu Phe Arg Asp Gly Xaa Ile Leu
                85                  90                  95      
Gly Lys Tyr
            


<210> 349
<211> 545
<212> PRT
<213> Homo sapiens

<400> 349
Ser Pro Gly Leu Glu Tyr Asn Val Ser Val Tyr Thr Val Lys Asp Asp
 1               5                  10                  15      
Lys Glu Asn Ser Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser
            20                  25                  30          
Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr
        35                  40                  45              
Val Tyr Ala Val Thr Gly Arg Gly Asp Ser Pro Ala Ser Ser Lys Pro
    50                  55                  60                  
Ile Ser Ile Asn Tyr Arg Thr Glu Ile Asp Lys Pro Ser Gln Met Gln
65                  70                  75                  80  
Val Thr Asp Val Gln Asp Asn Ser Ile Ser Val Lys Trp Leu Pro Ser
                85                  90                  95      
Ser Ser Pro Val Thr Gly Tyr Arg Val Thr Thr Thr Pro Lys Asn Gly
            100                 105                 110         
Pro Gly Pro Thr Lys Thr Lys Thr Ala Gly Pro Asp Gln Thr Glu Met
        115                 120                 125             
Thr Ile Glu Gly Leu Gln Pro Thr Val Glu Tyr Val Val Ser Val Tyr
    130                 135                 140                 
Ala Gln Asn Pro Ser Gly Glu Ser Gln Pro Leu Val Gln Thr Ala Val
145                 150                 155                 160 
Thr Thr Ile Pro Ala Pro Thr Asp Leu Lys Phe Thr Gln Val Thr Pro
                165                 170                 175     
Thr Ser Leu Ser Ala Gln Trp Thr Pro Pro Asn Val Gln Leu Thr Gly
            180                 185                 190         
Tyr Arg Val Arg Val Thr Pro Lys Glu Lys Thr Gly Pro Met Lys Glu
        195                 200                 205             
Ile Asn Leu Ala Pro Asp Ser Ser Ser Val Val Val Ser Gly Leu Met
    210                 215                 220                 
Val Ala Thr Lys Tyr Glu Val Ser Val Tyr Ala Leu Lys Asp Thr Leu
225                 230                 235                 240 
Thr Ser Arg Pro Ala Gln Gly Val Val Thr Thr Leu Glu Asn Val Ser
                245                 250                 255     
Pro Pro Arg Arg Ala Arg Val Thr Asp Ala Thr Glu Thr Thr Ile Thr
            260                 265                 270         
Ile Ser Trp Arg Thr Lys Thr Glu Thr Ile Thr Gly Phe Gln Val Asp
        275                 280                 285             
Ala Val Pro Ala Asn Gly Gln Thr Pro Ile Gln Arg Thr Ile Lys Pro
    290                 295                 300                 
Asp Val Arg Ser Tyr Thr Ile Thr Gly Leu Gln Pro Gly Thr Asp Tyr
305                 310                 315                 320 
Lys Ile Tyr Leu Tyr Thr Leu Asn Asp Asn Ala Arg Ser Ser Pro Val
                325                 330                 335     
Val Ile Asp Ala Ser Thr Ala Ile Asp Ala Pro Ser Asn Leu Arg Phe
            340                 345                 350         
Leu Ala Thr Thr Pro Asn Ser Leu Leu Val Ser Trp Gln Pro Pro Arg
        355                 360                 365             
Ala Arg Ile Thr Gly Tyr Ile Ile Lys Tyr Glu Lys Pro Gly Ser Pro
    370                 375                 380                 
Pro Arg Glu Val Val Pro Arg Pro Arg Pro Gly Val Thr Glu Ala Thr
385                 390                 395                 400 
Ile Thr Gly Leu Glu Pro Gly Thr Glu Tyr Thr Ile Tyr Val Ile Ala
                405                 410                 415     
Leu Lys Asn Asn Gln Lys Ser Glu Pro Leu Ile Gly Arg Lys Lys Thr
            420                 425                 430         
Val Gln Lys Thr Pro Phe Val Thr His Pro Gly Tyr Asp Thr Gly Asn
        435                 440                 445             
Gly Ile Gln Leu Pro Gly Thr Ser Gly Gln Gln Pro Ser Val Gly Gln
    450                 455                 460                 
Gln Met Ile Phe Glu Glu His Gly Phe Arg Arg Thr Thr Pro Pro Thr
465                 470                 475                 480 
Thr Ala Thr Pro Ile Arg His Arg Pro Arg Pro Tyr Pro Pro Asn Val
                485                 490                 495     
Gly Gln Glu Ala Leu Ser Gln Thr Thr Ile Ser Trp Ala Pro Phe Gln
            500                 505                 510         
Asp Thr Ser Glu Tyr Ile Ile Ser Cys His Pro Val Gly Thr Asp Glu
        515                 520                 525             
Glu Pro Leu Gln Phe Arg Val Pro Gly Thr Ser Thr Ser Ala Thr Leu
    530                 535                 540                 
Thr
545 


<210> 350
<211> 268
<212> PRT
<213> Homo sapiens

<400> 350
Gly Leu Ala Arg Leu Arg Gln Gln Asp Pro Gly Ala Ile Gln Arg Asp
 1               5                  10                  15      
Gly Leu Asp Leu Ala Arg Ser His Arg Gly Gln Gln Ala Pro Gly His
            20                  25                  30          
Tyr Pro His Arg Gly Glu Thr His Pro Asp Leu Gln Ala Glu Arg Pro
        35                  40                  45              
Arg His Leu Arg Leu Gly Asp Pro Gly Pro Pro Ala Gly Gly Arg Arg
    50                  55                  60                  
Val Arg Gln Val Gln Cys Ala Leu Arg Glu Leu His Gln Pro His Ser
65                  70                  75                  80  
Ala Gln Gln Asp Arg Gln Leu Gly Pro Ala Gly Ser Leu Arg Leu Ile
                85                  90                  95      
Gln Ala Ala Pro Ala Asp Ala Ala Ala Ser Ala Ala Leu Gln Pro His
            100                 105                 110         
Leu Leu Val Pro Gln Pro Tyr His Gly Gly Gly Arg Gln Gly Ala His
        115                 120                 125             
Ala Thr Arg Gly Ala Cys His Pro Arg Phe Gly Gly His Ala Ala His
    130                 135                 140                 
Leu Ala Leu Leu Ala Leu Arg His Arg His Pro Gly His Pro Leu His
145                 150                 155                 160 
His Arg Pro Ser Glu Arg Gln Leu Pro Leu Pro Gln Pro Gln Gly Gly
                165                 170                 175     
Gly Val Glu Gln Pro Gly Pro Gln Gln Leu Pro Arg Arg Arg Pro Ala
            180                 185                 190         
Arg Gly Glu Arg Val Gly Glu Gly Ser Pro Gly Ala Gly Ser Gln Val
        195                 200                 205             
Arg Ser Gly Thr Lys Trp Ser Pro Ser Cys Gly Gln Phe Cys Val Ser
    210                 215                 220                 
Ile Gln His Gly Ser Leu Pro Tyr Pro Ser Pro Ser Val Ala Leu His
225                 230                 235                 240 
Asp Leu Gln Cys Cys Ser Phe Trp Leu Cys Cys Trp Thr Trp Val Ala
                245                 250                 255     
Thr Cys Trp Gly His Leu Ile Val Ser Pro Gln Leu
            260                 265             


<210> 351
<211> 383
<212> PRT
<213> Homo sapiens

<400> 351
Met Ala Val Leu Ser Gly Val Arg Trp Leu Thr Arg Ala Leu Val Ser
 1               5                  10                  15      
Ala Gly Asn Pro Gly Ala Trp Arg Gly Leu Ser Thr Ser Ala Ala Ala
            20                  25                  30          
His Ala Ala Ser Arg Ser Gln Ala Glu Asp Val Arg Val Glu Gly Ser
        35                  40                  45              
Phe Pro Val Thr Met Leu Pro Gly Asp Gly Val Gly Pro Glu Leu Met
    50                  55                  60                  
His Ala Val Lys Glu Val Phe Lys Ala Ala Ala Val Pro Val Glu Phe
65                  70                  75                  80  
Gln Glu His His Leu Ser Glu Val Gln Asn Met Ala Ser Glu Glu Lys
                85                  90                  95      
Leu Glu Gln Val Leu Ser Ser Met Lys Glu Asn Lys Val Ala Ile Ile
            100                 105                 110         
Gly Lys Ile His Thr Pro Met Glu Tyr Lys Gly Glu Leu Ala Ser Tyr
        115                 120                 125             
Asp Met Arg Leu Arg Arg Lys Leu Asp Leu Phe Ala Asn Val Val His
    130                 135                 140                 
Val Lys Ser Leu Pro Gly Tyr Met Thr Arg His Asn Asn Leu Asp Leu
145                 150                 155                 160 
Val Ile Ile Arg Glu Gln Thr Glu Gly Glu Tyr Ser Ser Leu Glu His
                165                 170                 175     
Glu Ser Ala Arg Gly Val Ile Glu Cys Leu Lys Ile Val Thr Arg Ala
            180                 185                 190         
Lys Ser Gln Arg Ile Ala Lys Phe Ala Phe Asp Tyr Ala Thr Lys Lys
        195                 200                 205             
Gly Arg Gly Lys Val Thr Ala Val His Lys Ala Asn Ile Met Lys Leu
    210                 215                 220                 
Gly Asp Gly Leu Phe Leu Gln Cys Cys Glu Glu Val Ala Glu Leu Tyr
225                 230                 235                 240 
Pro Lys Ile Lys Phe Glu Thr Met Ile Ile Asp Asn Cys Cys Met Gln
                245                 250                 255     
Leu Val Gln Asn Pro Tyr Gln Phe Asp Val Leu Val Met Pro Asn Leu
            260                 265                 270         
Tyr Gly Asn Ile Ile Asp Asn Leu Ala Ala Gly Leu Val Gly Gly Ala
        275                 280                 285             
Gly Val Val Pro Gly Glu Ser Tyr Ser Ala Glu Tyr Ala Val Phe Glu
    290                 295                 300                 
Thr Gly Ala Arg His Pro Phe Ala Gln Ala Val Gly Arg Asn Ile Ala
305                 310                 315                 320 
Asn Pro Thr Ala Met Leu Leu Ser Ala Ser Asn Met Leu Arg His Leu
                325                 330                 335     
Asn Leu Glu Tyr His Ser Ser Met Ile Ala Asp Ala Val Lys Lys Val
            340                 345                 350         
Ile Lys Val Gly Lys Val Arg Thr Ser Asp Met Gly Gly Tyr Ala Thr
        355                 360                 365             
Cys His Asp Phe Thr Glu Ala Val Ile Ala Ala Leu Pro His Pro
    370                 375                 380             


<210> 352
<211> 548
<212> PRT
<213> Homo sapiens

<400> 352
Met Val Ala His Asp Glu Thr Gly Gly Leu Leu Pro Ile Lys Arg Thr
 1               5                  10                  15      
Ile Arg Val Leu Asp Val Asn Asn Gln Ser Phe Arg Glu Gln Glu Glu
            20                  25                  30          
Pro Ser Asn Lys Arg Val Arg Pro Leu Ala Arg Val Thr Ser Leu Ala
        35                  40                  45              
Asn Leu Ile Ser Pro Val Arg Asn Gly Ala Val Arg Arg Phe Gly Gln
    50                  55                  60                  
Thr Ile Gln Ser Phe Thr Leu Arg Gly Asp His Arg Ser Pro Ala Ser
65                  70                  75                  80  
Ala Gln Lys Phe Ser Ser Arg Ser Thr Val Pro Thr Pro Ala Lys Arg
                85                  90                  95      
Arg Ser Ser Ala Leu Trp Ser Glu Met Leu Asp Ile Thr Met Lys Glu
            100                 105                 110         
Ser Leu Thr Thr Arg Glu Ile Arg Arg Gln Glu Ala Ile Tyr Glu Met
        115                 120                 125             
Ser Arg Gly Glu Gln Asp Leu Ile Glu Asp Leu Lys Leu Ala Arg Lys
    130                 135                 140                 
Ala Tyr His Asp Pro Met Leu Lys Leu Ser Ile Met Ser Glu Glu Glu
145                 150                 155                 160 
Leu Thr His Ile Phe Gly Asp Leu Asp Ser Tyr Ile Pro Leu His Glu
                165                 170                 175     
Asp Leu Leu Thr Arg Ile Gly Glu Ala Thr Lys Pro Asp Gly Thr Val
            180                 185                 190         
Glu Gln Ile Gly His Ile Leu Val Ser Trp Leu Pro Arg Leu Asn Ala
        195                 200                 205             
Tyr Arg Gly Tyr Cys Ser Asn Gln Leu Ala Ala Lys Ala Leu Leu Asp
    210                 215                 220                 
Gln Lys Lys Gln Asp Pro Arg Val Gln Asp Phe Leu Gln Arg Cys Leu
225                 230                 235                 240 
Glu Ser Pro Phe Ser Arg Lys Leu Asp Leu Trp Ser Phe Leu Asp Ile
                245                 250                 255     
Pro Arg Ser Arg Leu Val Lys Tyr Pro Leu Leu Leu Lys Glu Ile Leu
            260                 265                 270         
Lys His Thr Pro Lys Glu His Pro Asp Val Gln Leu Leu Glu Asp Ala
        275                 280                 285             
Ile Leu Ile Ile Gln Gly Val Leu Ser Asp Ile Asn Leu Lys Lys Gly
    290                 295                 300                 
Glu Ser Glu Cys Gln Tyr Tyr Ile Asp Lys Leu Glu Tyr Leu Asp Glu
305                 310                 315                 320 
Lys Gln Arg Asp Pro Arg Ile Glu Ala Ser Lys Val Leu Leu Cys His
                325                 330                 335     
Gly Glu Leu Arg Ser Lys Ser Gly His Lys Leu Tyr Ile Phe Leu Phe
            340                 345                 350         
Gln Asp Ile Leu Val Leu Thr Arg Pro Val Thr Arg Asn Glu Arg His
        355                 360                 365             
Ser Tyr Gln Val Tyr Arg Gln Pro Ile Pro Val Gln Glu Leu Val Leu
    370                 375                 380                 
Glu Asp Leu Gln Asp Gly Asp Val Arg Met Gly Gly Ser Phe Arg Gly
385                 390                 395                 400 
Ala Phe Ser Asn Ser Glu Lys Ala Lys Asn Ile Phe Arg Ile Arg Phe
                405                 410                 415     
His Asp Pro Ser Pro Ala Gln Ser His Thr Leu Gln Ala Asn Asp Val
            420                 425                 430         
Phe His Lys Gln Gln Trp Phe Asn Cys Ile Arg Ala Ala Ile Ala Pro
        435                 440                 445             
Phe Gln Ser Ala Gly Ser Pro Pro Glu Leu Gln Gly Leu Pro Glu Leu
    450                 455                 460                 
His Glu Glu Cys Glu Gly Asn His Pro Ser Ala Arg Lys Leu Thr Ala
465                 470                 475                 480 
Gln Arg Arg Ala Ser Thr Val Ser Ser Val Thr Gln Val Glu Val Asp
                485                 490                 495     
Glu Asn Ala Tyr Arg Cys Gly Ser Gly Met Gln Met Ala Glu Asp Ser
            500                 505                 510         
Lys Ser Leu Lys Thr His Gln Thr Gln Pro Gly Ile Arg Arg Ala Arg
        515                 520                 525             
Asp Lys Ala Leu Leu Val Ala Asn Gly Lys Arg Leu Trp Cys Arg Glu
    530                 535                 540                 
Gly Ser Val Cys
545             


<210> 353
<211> 226
<212> PRT
<213> Homo sapiens

<400> 353
Ile Ile Gly Gly Thr Glu Ser Lys Pro His Ser Arg Pro Tyr Met Ala
 1               5                  10                  15      
Tyr Leu Glu Ile Val Thr Ser Asn Gly Pro Ser Lys Phe Cys Gly Gly
            20                  25                  30          
Phe Leu Ile Arg Arg Asn Phe Val Leu Thr Ala Ala His Cys Ala Gly
        35                  40                  45              
Arg Ser Ile Thr Val Thr Leu Gly Ala His Asn Ile Thr Glu Glu Glu
    50                  55                  60                  
Asp Thr Trp Gln Lys Leu Glu Val Ile Lys Gln Phe Arg His Pro Lys
65                  70                  75                  80  
Tyr Asn Thr Ser Thr Leu His His Asp Ile Met Leu Leu Lys Leu Lys
                85                  90                  95      
Glu Lys Ala Ser Leu Thr Leu Ala Val Gly Thr Leu Pro Phe Pro Ser
            100                 105                 110         
Gln Phe Asn Phe Val Pro Pro Gly Arg Met Cys Arg Val Ala Gly Trp
        115                 120                 125             
Gly Arg Thr Gly Val Leu Lys Pro Gly Ser Asp Thr Leu Gln Glu Val
    130                 135                 140                 
Lys Leu Arg Leu Met Asp Pro Gln Ala Cys Ser His Phe Arg Asp Phe
145                 150                 155                 160 
Asp His Asn Leu Gln Leu Cys Val Gly Asn Pro Arg Lys Thr Lys Ser
                165                 170                 175     
Ala Phe Lys Gly Asp Ser Gly Gly Pro Leu Leu Cys Ala Gly Val Ala
            180                 185                 190         
Gln Gly Ile Val Ser Tyr Gly Arg Ser Asp Ala Lys Pro Pro Ala Val
        195                 200                 205             
Phe Thr Arg Ile Ser His Tyr Arg Pro Trp Ile Asn Gln Ile Leu Gln
    210                 215                 220                 
Ala Asn
225     


<210> 354
<211> 3859
<212> PRT
<213> Homo sapiens

<400> 354
Met Ala Phe Val Ala Thr Gln Gly Ala Thr Val Val Asp Gln Thr Thr
 1               5                  10                  15      
Leu Met Lys Lys Tyr Leu Gln Phe Val Ala Ala Leu Thr Asp Val Asn
            20                  25                  30          
Thr Pro Asp Glu Thr Lys Leu Lys Met Met Gln Glu Val Ser Glu Asn
        35                  40                  45              
Phe Glu Asn Val Thr Ser Ser Pro Gln Tyr Ser Thr Phe Leu Glu His
    50                  55                  60                  
Ile Ile Pro Arg Phe Leu Thr Phe Leu Gln Asp Gly Glu Val Gln Phe
65                  70                  75                  80  
Leu Gln Glu Lys Pro Ala Gln Gln Leu Arg Lys Leu Val Leu Glu Ile
                85                  90                  95      
Ile His Arg Ile Pro Thr Asn Glu His Leu Arg Pro His Thr Lys Asn
            100                 105                 110         
Val Leu Ser Val Met Phe Arg Phe Leu Glu Thr Glu Asn Glu Glu Asn
        115                 120                 125             
Val Leu Ile Cys Leu Arg Ile Ile Ile Glu Leu His Lys Gln Phe Arg
    130                 135                 140                 
Pro Pro Ile Thr Gln Glu Ile His His Phe Leu Asp Phe Val Lys Gln
145                 150                 155                 160 
Ile Tyr Lys Glu Leu Pro Lys Val Val Asn Arg Tyr Phe Glu Asn Pro
                165                 170                 175     
Gln Val Ile Pro Glu Asn Thr Val Pro Pro Pro Glu Met Val Gly Met
            180                 185                 190         
Ile Thr Thr Ile Ala Val Lys Val Asn Pro Glu Arg Glu Asp Ser Glu
        195                 200                 205             
Thr Arg Thr His Ser Ile Ile Pro Arg Gly Ser Leu Ser Leu Lys Val
    210                 215                 220                 
Leu Ala Glu Leu Pro Ile Ile Val Val Leu Met Tyr Gln Leu Tyr Lys
225                 230                 235                 240 
Leu Asn Ile His Asn Val Val Ala Glu Phe Val Pro Leu Ile Met Asn
                245                 250                 255     
Thr Ile Ala Ile Gln Val Ser Ala Gln Ala Arg Gln His Lys Leu Tyr
            260                 265                 270         
Asn Lys Glu Leu Tyr Ala Asp Phe Ile Ala Ala Gln Ile Lys Thr Leu
        275                 280                 285             
Ser Phe Leu Ala Tyr Ile Ile Arg Ile Tyr Gln Glu Leu Val Thr Lys
    290                 295                 300                 
Tyr Ser Gln Gln Met Val Lys Gly Met Leu Gln Leu Leu Ser Asn Cys
305                 310                 315                 320 
Pro Ala Glu Thr Ala His Leu Arg Lys Glu Leu Leu Ile Ala Ala Lys
                325                 330                 335     
His Ile Leu Thr Thr Glu Leu Arg Asn Gln Phe Ile Pro Cys Met Asp
            340                 345                 350         
Lys Leu Phe Asp Glu Ser Ile Leu Ile Gly Ser Gly Tyr Thr Ala Arg
        355                 360                 365             
Glu Thr Leu Arg Pro Leu Ala Tyr Ser Thr Leu Ala Asp Leu Val His
    370                 375                 380                 
His Val Arg Gln His Leu Pro Leu Ser Asp Leu Ser Leu Ala Val Gln
385                 390                 395                 400 
Leu Phe Ala Lys Asn Ile Asp Asp Glu Ser Leu Pro Ser Ser Ile Gln
                405                 410                 415     
Thr Met Ser Cys Lys Leu Leu Leu Asn Leu Val Asp Cys Ile Arg Ser
            420                 425                 430         
Lys Ser Glu Gln Glu Ser Gly Asn Gly Arg Asp Val Leu Met Arg Met
        435                 440                 445             
Leu Glu Val Phe Val Leu Lys Phe His Thr Ile Ala Arg Tyr Gln Leu
    450                 455                 460                 
Ser Ala Ile Phe Lys Lys Cys Lys Pro Gln Ser Glu Leu Gly Ala Val
465                 470                 475                 480 
Glu Ala Ala Leu Pro Gly Val Pro Thr Ala Pro Ala Ala Pro Gly Pro
                485                 490                 495     
Ala Pro Ser Pro Ala Pro Val Pro Ala Pro Pro Pro Pro Pro Pro Pro
            500                 505                 510         
Pro Pro Pro Ala Thr Pro Val Thr Pro Ala Pro Val Pro Pro Phe Glu
        515                 520                 525             
Lys Gln Gly Glu Lys Asp Lys Glu Asp Lys Gln Thr Phe Gln Val Thr
    530                 535                 540                 
Asp Cys Arg Ser Leu Val Lys Thr Leu Val Cys Gly Val Lys Thr Ile
545                 550                 555                 560 
Thr Trp Gly Ile Thr Ser Cys Lys Ala Pro Gly Glu Ala Gln Phe Ile
                565                 570                 575     
Pro Asn Lys Gln Leu Gln Pro Lys Glu Thr Gln Ile Tyr Ile Lys Leu
            580                 585                 590         
Val Lys Tyr Ala Met Gln Ala Leu Asp Ile Tyr Gln Val Gln Ile Ala
        595                 600                 605             
Gly Asn Gly Gln Thr Tyr Ile Arg Val Ala Asn Cys Gln Thr Val Arg
    610                 615                 620                 
Met Lys Glu Glu Lys Glu Val Leu Glu His Phe Ala Gly Val Phe Thr
625                 630                 635                 640 
Met Met Asn Pro Leu Thr Phe Lys Glu Ile Phe Gln Thr Thr Val Pro
                645                 650                 655     
Tyr Met Val Asp Arg Ile Ser Lys Asn Tyr Ala Leu Gln Ile Val Ala
            660                 665                 670         
Asn Ser Phe Leu Ala Asn Pro Thr Thr Ser Ala Leu Phe Ala Thr Ile
        675                 680                 685             
Leu Val Glu Tyr Leu Leu Asp Arg Leu Pro Glu Met Gly Ser Asn Val
    690                 695                 700                 
Glu Leu Ser Asn Leu Tyr Leu Lys Leu Phe Lys Leu Val Phe Gly Ser
705                 710                 715                 720 
Val Ser Leu Phe Ala Ala Glu Asn Glu Gln Met Leu Lys Pro His Leu
                725                 730                 735     
His Lys Ile Val Asn Ser Ser Met Glu Leu Ala Gln Thr Ala Lys Glu
            740                 745                 750         
Pro Tyr Asn Tyr Phe Leu Leu Leu Arg Ala Leu Phe Arg Ser Ile Gly
        755                 760                 765             
Gly Gly Ser His Asp Leu Leu Tyr Gln Glu Phe Leu Pro Leu Leu Pro
    770                 775                 780                 
Asn Leu Leu Gln Gly Leu Asn Met Leu Gln Ser Gly Leu His Lys Gln
785                 790                 795                 800 
His Met Lys Asp Leu Phe Val Glu Leu Cys Leu Thr Val Pro Val Arg
                805                 810                 815     
Leu Ser Ser Leu Leu Pro Tyr Leu Pro Met Leu Met Asp Pro Leu Val
            820                 825                 830         
Ser Ala Leu Asn Gly Ser Gln Thr Leu Val Ser Gln Gly Leu Arg Thr
        835                 840                 845             
Leu Glu Leu Cys Val Asp Asn Leu Gln Pro Asp Phe Leu Tyr Asp His
    850                 855                 860                 
Ile Gln Pro Val Arg Ala Glu Leu Met Gln Ala Leu Trp Arg Thr Leu
865                 870                 875                 880 
Arg Asn Pro Ala Asp Ser Ile Ser His Val Ala Tyr Arg Val Leu Gly
                885                 890                 895     
Lys Phe Gly Gly Ser Asn Arg Lys Met Leu Lys Glu Ser Gln Lys Leu
            900                 905                 910         
His Tyr Val Val Thr Glu Val Gln Gly Pro Ser Ile Thr Val Glu Phe
        915                 920                 925             
Ser Asp Cys Lys Ala Ser Leu Gln Leu Pro Met Glu Lys Ala Ile Glu
    930                 935                 940                 
Thr Ala Leu Asp Cys Leu Lys Ser Ala Asn Thr Glu Pro Tyr Tyr Arg
945                 950                 955                 960 
Arg Gln Ala Trp Glu Val Ile Lys Cys Phe Leu Val Ala Met Met Ser
                965                 970                 975     
Leu Glu Asp Asn Lys His Ala Leu Tyr Gln Leu Leu Ala His Pro Asn
            980                 985                 990         
Phe Thr Glu Lys Thr Ile Pro Asn Val Ile Ile Ser His Arg Tyr Lys
        995                 1000                1005            
Ala Gln Asp Thr Pro Ala Arg Lys Thr Phe Glu Gln Ala Leu Thr Gly
    1010                1015                1020                
Ala Phe Met Ser Ala Val Ile Lys Asp Leu Arg Pro Ser Ala Leu Pro
1025                1030                1035                1040
Phe Val Ala Ser Leu Ile Arg His Tyr Thr Met Val Ala Val Ala Gln
                1045                1050                1055    
Gln Cys Gly Pro Phe Leu Leu Pro Cys Tyr Gln Val Gly Ser Gln Pro
            1060                1065                1070        
Ser Thr Ala Met Phe His Ser Glu Glu Asn Gly Ser Lys Gly Met Asp
        1075                1080                1085            
Pro Leu Val Leu Ile Asp Ala Ile Ala Ile Cys Met Ala Tyr Glu Glu
    1090                1095                1100                
Lys Glu Leu Cys Lys Ile Gly Glu Val Ala Leu Ala Val Ile Phe Asp
1105                1110                1115                1120
Val Ala Ser Ile Ile Leu Gly Ser Lys Glu Arg Ala Cys Gln Leu Pro
                1125                1130                1135    
Leu Phe Ser Tyr Ile Val Glu Arg Leu Cys Ala Cys Cys Tyr Glu Gln
            1140                1145                1150        
Ala Trp Tyr Ala Lys Leu Gly Gly Val Val Ser Ile Lys Phe Leu Met
        1155                1160                1165            
Glu Arg Leu Pro Leu Thr Trp Val Leu Gln Asn Gln Gln Thr Phe Leu
    1170                1175                1180                
Lys Ala Leu Leu Phe Val Met Met Asp Leu Thr Gly Glu Val Ser Asn
1185                1190                1195                1200
Gly Ala Val Ala Met Ala Lys Thr Thr Leu Glu Gln Leu Leu Met Arg
                1205                1210                1215    
Cys Ala Thr Pro Leu Lys Asp Glu Glu Arg Ala Glu Glu Ile Val Ala
            1220                1225                1230        
Ala Gln Glu Lys Ser Phe His His Val Thr His Asp Leu Val Arg Glu
        1235                1240                1245            
Val Thr Ser Pro Asn Ser Thr Val Arg Lys Gln Ala Met His Ser Leu
    1250                1255                1260                
Gln Val Leu Ala Gln Val Thr Gly Lys Ser Val Thr Val Ile Met Glu
1265                1270                1275                1280
Pro His Lys Glu Val Leu Gln Asp Met Val Pro Pro Lys Lys His Leu
                1285                1290                1295    
Leu Arg His Gln Pro Ala Asn Ala Gln Ile Gly Leu Met Glu Gly Asn
            1300                1305                1310        
Thr Phe Cys Thr Thr Leu Gln Pro Arg Leu Phe Thr Met Asp Leu Asn
        1315                1320                1325            
Val Val Glu His Lys Val Phe Tyr Thr Glu Leu Leu Asn Leu Cys Glu
    1330                1335                1340                
Ala Glu Asp Ser Ala Leu Thr Lys Leu Pro Cys Tyr Lys Ser Leu Pro
1345                1350                1355                1360
Ser Leu Val Pro Leu Arg Ile Ala Ala Leu Asn Ala Leu Ala Ala Cys
                1365                1370                1375    
Asn Tyr Leu Pro Gln Ser Arg Glu Lys Ile Ile Ala Ala Leu Phe Lys
            1380                1385                1390        
Ala Leu Asn Ser Thr Asn Ser Glu Leu Gln Glu Ala Gly Glu Ala Cys
        1395                1400                1405            
Met Arg Lys Phe Leu Glu Gly Ala Thr Ile Glu Val Asp Gln Ile His
    1410                1415                1420                
Thr His Met Arg Pro Leu Leu Met Met Leu Gly Asp Tyr Arg Ser Leu
1425                1430                1435                1440
Thr Leu Asn Val Val Asn Arg Leu Thr Ser Val Thr Arg Leu Phe Pro
                1445                1450                1455    
Asn Ser Phe Asn Asp Lys Phe Cys Asp Gln Met Met Gln His Leu Arg
            1460                1465                1470        
Lys Trp Met Glu Val Val Val Ile Thr His Lys Gly Gly Gln Arg Ser
        1475                1480                1485            
Asp Gly Asn Glu Ser Ile Ser Glu Cys Gly Arg Cys Pro Leu Ser Pro
    1490                1495                1500                
Phe Cys Gln Phe Glu Glu Met Lys Ile Cys Ser Ala Ile Ile Asn Leu
1505                1510                1515                1520
Phe His Leu Ile Pro Ala Ala Pro Gln Thr Leu Val Lys Pro Leu Leu
                1525                1530                1535    
Glu Val Val Met Lys Thr Glu Arg Ala Met Leu Ile Glu Ala Gly Ser
            1540                1545                1550        
Pro Phe Arg Glu Pro Leu Ile Lys Phe Leu Thr Arg His Pro Ser Gln
        1555                1560                1565            
Thr Val Glu Leu Phe Met Met Glu Ala Thr Leu Asn Asp Pro Gln Trp
    1570                1575                1580                
Ser Arg Met Phe Met Ser Phe Leu Lys His Lys Asp Ala Arg Pro Leu
1585                1590                1595                1600
Arg Asp Val Leu Ala Ala Asn Pro Asn Arg Phe Ile Thr Leu Leu Leu
                1605                1610                1615    
Pro Gly Gly Ala Gln Thr Ala Val Arg Pro Gly Ser Pro Ser Thr Ser
            1620                1625                1630        
Thr Met Arg Leu Asp Leu Gln Phe Gln Ala Ile Lys Ile Ile Ser Ile
        1635                1640                1645            
Ile Val Lys Asn Asp Asp Ser Trp Leu Ala Ser Gln His Ser Leu Val
    1650                1655                1660                
Ser Gln Leu Arg Arg Val Trp Val Ser Glu Asn Phe Gln Glu Arg His
1665                1670                1675                1680
Arg Lys Glu Asn Met Ala Ala Thr Asn Trp Lys Glu Pro Lys Leu Leu
                1685                1690                1695    
Ala Tyr Cys Leu Leu Asn Tyr Cys Lys Arg Asn Tyr Gly Asp Ile Glu
            1700                1705                1710        
Leu Leu Phe Gln Leu Leu Arg Ala Phe Thr Gly Arg Phe Leu Cys Asn
        1715                1720                1725            
Met Thr Phe Leu Lys Glu Tyr Met Glu Glu Glu Ile Pro Lys Asn Tyr
    1730                1735                1740                
Ser Ile Ala Gln Lys Arg Ala Leu Phe Phe Arg Phe Val Asp Phe Asn
1745                1750                1755                1760
Asp Pro Asn Phe Gly Asp Glu Leu Lys Ala Lys Val Leu Gln His Ile
                1765                1770                1775    
Leu Asn Pro Ala Phe Leu Tyr Ser Phe Glu Lys Gly Glu Gly Glu Gln
            1780                1785                1790        
Leu Leu Gly Pro Pro Asn Pro Glu Gly Asp Asn Pro Glu Ser Ile Thr
        1795                1800                1805            
Ser Val Phe Ile Thr Lys Val Leu Asp Pro Glu Lys Gln Ala Asp Met
    1810                1815                1820                
Leu Asp Ser Leu Arg Ile Tyr Leu Leu Gln Tyr Ala Thr Leu Leu Val
1825                1830                1835                1840
Glu His Ala Pro His His Ile His Asp Asn Asn Lys Asn Arg Asn Ser
                1845                1850                1855    
Lys Leu Arg Arg Leu Met Thr Phe Ala Trp Pro Cys Leu Leu Ser Lys
            1860                1865                1870        
Ala Cys Val Asp Pro Ala Cys Lys Tyr Ser Gly His Leu Leu Leu Ala
        1875                1880                1885            
His Ile Ile Ala Lys Phe Ala Ile His Lys Lys Ile Val Leu Gln Val
    1890                1895                1900                
Phe His Ser Leu Leu Lys Ala His Ala Met Glu Ala Arg Ala Ile Val
1905                1910                1915                1920
Arg Gln Ala Met Ala Ile Leu Thr Pro Ala Val Pro Ala Arg Met Glu
                1925                1930                1935    
Asp Gly His Gln Met Leu Thr His Trp Thr Arg Lys Ile Ile Val Glu
            1940                1945                1950        
Glu Gly His Thr Val Pro Gln Leu Val His Ile Leu His Leu Ile Val
        1955                1960                1965            
Gln His Phe Lys Val Tyr Tyr Pro Val Arg His His Leu Val Gln His
    1970                1975                1980                
Met Val Ser Ala Met Gln Arg Leu Gly Phe Thr Pro Ser Val Thr Ile
1985                1990                1995                2000
Glu Gln Arg Arg Leu Ala Val Asp Leu Ser Glu Val Val Ile Lys Trp
                2005                2010                2015    
Glu Leu Gln Arg Ile Lys Asp Gln Gln Pro Asp Ser Asp Met Asp Pro
            2020                2025                2030        
Asn Ser Ser Gly Glu Gly Val Asn Ser Val Ser Ser Ser Ile Lys Arg
        2035                2040                2045            
Gly Leu Ser Val Asp Ser Ala Gln Glu Val Lys Arg Phe Arg Thr Ala
    2050                2055                2060                
Thr Gly Ala Ile Ser Ala Val Phe Gly Arg Ser Gln Ser Leu Pro Gly
2065                2070                2075                2080
Ala Asp Ser Leu Leu Ala Lys Pro Ile Asp Lys Gln His Thr Asp Thr
                2085                2090                2095    
Val Val Asn Phe Leu Ile Arg Val Ala Cys Gln Val Asn Asp Asn Thr
            2100                2105                2110        
Asn Thr Ala Gly Ser Pro Gly Glu Val Leu Ser Arg Arg Cys Val Asn
        2115                2120                2125            
Leu Leu Lys Thr Ala Leu Arg Pro Asp Met Trp Pro Lys Ser Glu Leu
    2130                2135                2140                
Lys Leu Gln Trp Phe Asp Lys Leu Leu Met Thr Val Glu Gln Pro Asn
2145                2150                2155                2160
Gln Val Asn Tyr Gly Asn Ile Cys Thr Gly Leu Glu Val Leu Ser Phe
                2165                2170                2175    
Leu Leu Thr Val Leu Gln Ser Pro Ala Ile Leu Ser Ser Phe Lys Pro
            2180                2185                2190        
Leu Gln Arg Gly Ile Ala Ala Cys Met Thr Cys Gly Asn Thr Lys Val
        2195                2200                2205            
Leu Arg Ala Val His Ser Leu Leu Ser Arg Leu Met Ser Ile Phe Pro
    2210                2215                2220                
Thr Glu Pro Ser Thr Ser Ser Val Ala Ser Lys Tyr Glu Glu Leu Glu
2225                2230                2235                2240
Cys Leu Tyr Ala Ala Val Gly Lys Val Ile Tyr Glu Gly Leu Thr Asn
                2245                2250                2255    
Tyr Glu Lys Ala Thr Asn Ala Asn Pro Ser Gln Leu Phe Gly Thr Leu
            2260                2265                2270        
Met Ile Leu Lys Ser Ala Cys Ser Asn Asn Pro Ser Tyr Ile Asp Arg
        2275                2280                2285            
Leu Ile Ser Val Phe Met Arg Ser Leu Gln Lys Met Val Arg Glu His
    2290                2295                2300                
Leu Asn Pro Gln Ala Ala Ser Gly Ser Thr Glu Ala Thr Ser Gly Thr
2305                2310                2315                2320
Ser Glu Leu Val Met Leu Ser Leu Glu Leu Val Lys Thr Arg Leu Ala
                2325                2330                2335    
Val Met Ser Met Glu Met Arg Lys Asn Phe Ile Gln Ala Ile Leu Thr
            2340                2345                2350        
Ser Leu Ile Glu Lys Ser Pro Asp Ala Lys Ile Leu Arg Ala Val Val
        2355                2360                2365            
Lys Ile Val Glu Glu Trp Val Lys Asn Asn Ser Pro Met Ala Ala Asn
    2370                2375                2380                
Gln Thr Pro Thr Leu Arg Glu Lys Ser Ile Leu Leu Val Lys Met Met
2385                2390                2395                2400
Thr Tyr Ile Glu Lys Arg Phe Pro Glu Asp Leu Glu Leu Asn Ala Gln
                2405                2410                2415    
Phe Leu Asp Leu Val Asn Tyr Val Tyr Arg Asp Glu Thr Leu Ser Gly
            2420                2425                2430        
Ser Glu Leu Thr Ala Lys Leu Glu Pro Ala Phe Leu Ser Gly Leu Arg
        2435                2440                2445            
Cys Ala Gln Pro Leu Ile Arg Ala Lys Phe Phe Glu Val Phe Asp Asn
    2450                2455                2460                
Ser Met Lys Arg Arg Val Tyr Glu Arg Leu Leu Tyr Val Thr Cys Ser
2465                2470                2475                2480
Gln Asn Trp Glu Ala Met Gly Asn His Phe Trp Ile Lys Gln Cys Ile
                2485                2490                2495    
Glu Leu Leu Leu Ala Val Cys Glu Lys Ser Thr Pro Ile Gly Thr Ser
            2500                2505                2510        
Cys Gln Gly Ala Met Leu Pro Ser Ile Thr Asn Val Ile Asn Leu Ala
        2515                2520                2525            
Asp Ser His Asp Arg Ala Ala Phe Ala Met Val Thr His Val Lys Gln
    2530                2535                2540                
Glu Pro Arg Glu Arg Glu Asn Ser Glu Ser Lys Glu Glu Asp Val Glu
2545                2550                2555                2560
Ile Asp Ile Glu Leu Ala Pro Gly Asp Gln Thr Ser Thr Pro Lys Thr
                2565                2570                2575    
Lys Glu Leu Ser Glu Lys Asp Ile Gly Asn Gln Leu His Met Leu Thr
            2580                2585                2590        
Asn Arg His Asp Lys Phe Leu Asp Thr Leu Arg Glu Val Lys Thr Gly
        2595                2600                2605            
Ala Leu Leu Ser Ala Phe Val Gln Leu Cys His Ile Ser Thr Thr Leu
    2610                2615                2620                
Ala Glu Lys Thr Trp Val Gln Leu Phe Pro Arg Leu Trp Lys Ile Leu
2625                2630                2635                2640
Ser Asp Arg Gln Gln His Ala Leu Ala Gly Glu Ile Ser Pro Phe Leu
                2645                2650                2655    
Cys Ser Gly Ser His Gln Val Gln Arg Asp Cys Gln Pro Ser Ala Leu
            2660                2665                2670        
Asn Cys Phe Val Glu Ala Met Ser Gln Cys Val Pro Pro Ile Pro Ile
        2675                2680                2685            
Arg Pro Cys Val Leu Lys Tyr Leu Gly Lys Thr His Asn Leu Trp Phe
    2690                2695                2700                
Arg Ser Thr Leu Met Leu Glu His Gln Ala Phe Glu Lys Gly Leu Ser
2705                2710                2715                2720
Leu Gln Ile Lys Pro Lys Gln Thr Thr Glu Phe Tyr Glu Gln Glu Ser
                2725                2730                2735    
Ile Thr Pro Pro Gln Gln Glu Ile Leu Asp Ser Leu Ala Glu Leu Tyr
            2740                2745                2750        
Ser Leu Leu Gln Glu Glu Asp Met Trp Ala Gly Leu Trp Gln Lys Arg
        2755                2760                2765            
Cys Lys Tyr Ser Glu Thr Ala Thr Ala Ile Ala Tyr Glu Gln His Gly
    2770                2775                2780                
Phe Phe Glu Gln Ala Gln Glu Ser Tyr Glu Lys Ala Met Asp Lys Ala
2785                2790                2795                2800
Lys Lys Glu His Glu Arg Ser Asn Ala Ser Pro Ala Ile Phe Pro Glu
                2805                2810                2815    
Tyr Gln Leu Trp Glu Asp His Trp Ile Arg Cys Ser Lys Glu Leu Asn
            2820                2825                2830        
Gln Trp Glu Ala Leu Thr Glu Tyr Gly Gln Ser Lys Gly His Ile Asn
        2835                2840                2845            
Pro Tyr Leu Val Leu Glu Cys Ala Trp Arg Val Ser Asn Trp Thr Ala
    2850                2855                2860                
Met Lys Glu Ala Leu Val Gln Val Glu Val Ser Cys Pro Lys Glu Met
2865                2870                2875                2880
Ala Trp Lys Val Asn Met Tyr Arg Gly Tyr Leu Ala Ile Cys His Pro
                2885                2890                2895    
Glu Glu Gln Gln Leu Ser Phe Ile Glu Arg Leu Val Glu Met Ala Ser
            2900                2905                2910        
Ser Leu Ala Ile Arg Glu Trp Arg Arg Leu Pro His Val Val Ser His
        2915                2920                2925            
Val His Thr Pro Leu Leu Gln Ala Ala Gln Gln Ile Ile Glu Leu Gln
    2930                2935                2940                
Glu Ala Ala Gln Ile Asn Ala Gly Leu Gln Pro Thr Asn Leu Gly Arg
2945                2950                2955                2960
Asn Asn Ser Leu His Asp Met Lys Thr Val Val Lys Thr Trp Arg Asn
                2965                2970                2975    
Arg Leu Pro Ile Val Ser Asp Asp Leu Ser His Trp Ser Ser Ile Phe
            2980                2985                2990        
Met Trp Arg Gln His His Tyr Gln Gly Lys Pro Thr Trp Ser Gly Met
        2995                3000                3005            
His Ser Ser Ser Ile Val Thr Ala Tyr Glu Asn Ser Ser Gln His Asp
    3010                3015                3020                
Pro Ser Ser Asn Asn Ala Met Leu Gly Val His Ala Ser Ala Ser Ala
3025                3030                3035                3040
Ile Ile Gln Tyr Gly Lys Ile Ala Arg Lys Gln Gly Leu Val Asn Val
                3045                3050                3055    
Ala Leu Asp Ile Leu Ser Arg Ile His Thr Ile Pro Thr Val Pro Ile
            3060                3065                3070        
Val Asp Cys Phe Gln Lys Ile Arg Gln Gln Val Lys Cys Tyr Leu Gln
        3075                3080                3085            
Leu Ala Gly Val Met Gly Lys Asn Glu Cys Met Gln Gly Leu Glu Val
    3090                3095                3100                
Ile Glu Ser Thr Asn Leu Lys Tyr Phe Thr Lys Glu Met Thr Ala Glu
3105                3110                3115                3120
Phe Tyr Ala Leu Lys Gly Met Phe Leu Ala Gln Ile Asn Lys Ser Glu
                3125                3130                3135    
Glu Ala Asn Lys Ala Phe Ser Ala Ala Val Gln Met His Asp Val Leu
            3140                3145                3150        
Val Lys Ala Trp Ala Met Trp Gly Asp Tyr Leu Glu Asn Ile Phe Val
        3155                3160                3165            
Lys Glu Arg Gln Leu His Leu Gly Val Ser Ala Ile Thr Cys Tyr Leu
    3170                3175                3180                
His Ala Cys Arg His Gln Asn Glu Ser Lys Ser Arg Lys Tyr Leu Ala
3185                3190                3195                3200
Lys Val Leu Trp Leu Leu Ser Phe Asp Asp Asp Lys Asn Thr Leu Ala
                3205                3210                3215    
Asp Ala Val Asp Lys Tyr Cys Ile Gly Val Pro Pro Ile Gln Trp Leu
            3220                3225                3230        
Ala Trp Ile Pro Gln Leu Leu Thr Cys Leu Val Gly Ser Glu Gly Lys
        3235                3240                3245            
Leu Leu Leu Asn Leu Ile Ser Gln Val Gly Arg Val Tyr Pro Gln Ala
    3250                3255                3260                
Val Tyr Phe Pro Ile Arg Thr Leu Tyr Leu Thr Leu Lys Ile Glu Gln
3265                3270                3275                3280
Arg Glu Arg Tyr Lys Ser Asp Pro Gly Pro Ile Arg Ala Thr Ala Pro
                3285                3290                3295    
Met Trp Arg Cys Ser Arg Ile Met His Met Gln Arg Glu Leu His Pro
            3300                3305                3310        
Thr Leu Leu Ser Ser Leu Glu Gly Ile Val Asp Gln Met Val Trp Phe
        3315                3320                3325            
Arg Glu Asn Trp His Glu Glu Val Leu Arg Gln Leu Gln Gln Gly Leu
    3330                3335                3340                
Ala Lys Cys Tyr Ser Val Ala Phe Glu Lys Ser Gly Ala Val Ser Asp
3345                3350                3355                3360
Ala Lys Ile Thr Pro His Thr Leu Asn Phe Val Lys Lys Leu Val Ser
                3365                3370                3375    
Thr Phe Gly Val Gly Leu Glu Asn Val Ser Asn Val Ser Thr Met Phe
            3380                3385                3390        
Ser Ser Ala Ala Ser Glu Ser Leu Ala Arg Arg Ala Gln Ala Thr Ala
        3395                3400                3405            
Gln Asp Pro Val Phe Gln Lys Leu Lys Gly Gln Phe Thr Thr Asp Phe
    3410                3415                3420                
Asp Phe Ser Val Pro Gly Ser Met Lys Leu His Asn Leu Ile Ser Lys
3425                3430                3435                3440
Leu Lys Lys Trp Ile Lys Ile Leu Glu Ala Lys Thr Lys Gln Leu Pro
                3445                3450                3455    
Lys Phe Phe Leu Ile Glu Glu Lys Cys Arg Phe Leu Ser Asn Phe Ser
            3460                3465                3470        
Ala Gln Thr Ala Glu Val Glu Ile Pro Gly Glu Phe Leu Met Pro Lys
        3475                3480                3485            
Pro Thr His Tyr Tyr Ile Lys Ile Ala Arg Phe Met Pro Arg Val Glu
    3490                3495                3500                
Ile Val Gln Lys His Asn Thr Ala Ala Arg Arg Leu Tyr Ile Arg Gly
3505                3510                3515                3520
His Asn Gly Lys Ile Tyr Pro Tyr Leu Val Met Asn Asp Ala Cys Leu
                3525                3530                3535    
Thr Glu Ser Arg Arg Glu Glu Arg Val Leu Gln Leu Leu Arg Leu Leu
            3540                3545                3550        
Asn Pro Cys Leu Glu Lys Arg Lys Glu Thr Thr Lys Arg His Leu Phe
        3555                3560                3565            
Phe Thr Val Pro Arg Val Val Ala Val Ser Pro Gln Met Arg Leu Val
    3570                3575                3580                
Glu Asp Asn Pro Ser Ser Leu Ser Leu Val Glu Ile Tyr Lys Gln Arg
3585                3590                3595                3600
Cys Ala Lys Lys Gly Ile Glu His Asp Asn Pro Ile Ser Arg Tyr Tyr
                3605                3610                3615    
Asp Arg Leu Ala Thr Val Gln Ala Arg Gly Thr Gln Ala Ser His Gln
            3620                3625                3630        
Val Leu Arg Asp Ile Leu Lys Glu Val Gln Ser Asn Met Val Pro Arg
        3635                3640                3645            
Ser Met Leu Lys Glu Trp Ala Leu His Thr Phe Pro Asn Ala Thr Asp
    3650                3655                3660                
Tyr Trp Thr Phe Arg Lys Met Phe Thr Ile Gln Leu Ala Leu Ile Gly
3665                3670                3675                3680
Phe Ala Glu Phe Val Leu His Leu Asn Arg Leu Asn Pro Glu Met Leu
                3685                3690                3695    
Gln Ile Ala Gln Asp Thr Gly Lys Leu Asn Val Ala Tyr Phe Arg Phe
            3700                3705                3710        
Asp Ile Asn Asp Ala Thr Gly Asp Leu Asp Ala Asn Arg Pro Val Pro
        3715                3720                3725            
Phe Arg Leu Thr Pro Asn Ile Ser Glu Phe Leu Thr Thr Ile Gly Val
    3730                3735                3740                
Ser Gly Pro Leu Thr Ala Ser Met Ile Ala Val Ala Arg Cys Phe Ala
3745                3750                3755                3760
Gln Pro Asn Phe Lys Val Asp Gly Ile Leu Lys Thr Val Leu Arg Asp
                3765                3770                3775    
Glu Ile Ile Ala Trp His Lys Lys Thr Gln Glu Asp Thr Ser Ser Pro
            3780                3785                3790        
Leu Ser Ala Ala Gly Gln Pro Glu Asn Met Asp Ser Gln Gln Leu Val
        3795                3800                3805            
Ser Leu Val Gln Lys Ala Val Thr Ala Ile Met Thr Arg Leu His Asn
    3810                3815                3820                
Leu Ala Gln Phe Glu Gly Gly Glu Ser Lys Val Asn Thr Leu Val Ala
3825                3830                3835                3840
Ala Ala Asn Ser Leu Asp Asn Leu Cys Arg Met Asp Pro Ala Trp His
                3845                3850                3855    
Pro Trp Leu
            


<210> 355
<211> 134
<212> PRT
<213> Homo sapiens

<400> 355
Met Phe Arg Arg Pro Val Leu Gln Val Leu Arg Gln Phe Val Arg His
 1               5                  10                  15      
Glu Ser Glu Thr Thr Thr Ser Leu Val Leu Glu Arg Ser Leu Asn Arg
            20                  25                  30          
Val His Leu Leu Gly Arg Val Gly Gln Asp Pro Val Leu Arg Gln Val
        35                  40                  45              
Glu Gly Lys Asn Pro Val Thr Ile Phe Ser Leu Ala Thr Asn Glu Met
    50                  55                  60                  
Trp Arg Ser Gly Asp Ser Glu Val Tyr Gln Leu Gly Asp Val Ser Gln
65                  70                  75                  80  
Lys Thr Thr Trp His Arg Ile Ser Val Phe Arg Pro Gly Leu Arg Asp
                85                  90                  95      
Val Ala Tyr Gln Tyr Val Lys Lys Gly Ser Arg Ile Tyr Leu Glu Gly
            100                 105                 110         
Lys Ile Asp Tyr Gly Glu Tyr Met Asp Lys Asn Asn Val Arg Arg Gln
        115                 120                 125             
Ala Thr Thr Ile Ile Ala
    130                 


<210> 356
<211> 230
<212> PRT
<213> Homo sapiens

<400> 356
Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr
 1               5                  10                  15      
Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly
            20                  25                  30          
Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser
        35                  40                  45              
Thr Glu Lys Asn Ala Ile Pro Ala Pro Thr Thr Thr Lys Ser Cys Arg
    50                  55                  60                  
Glu Thr Phe Leu Lys Trp Pro Gly Ser Val Val Val Gln Leu Thr Leu
65                  70                  75                  80  
Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe
                85                  90                  95      
Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser
            100                 105                 110         
Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly
        115                 120                 125             
Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val
    130                 135                 140                 
Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln
145                 150                 155                 160 
Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp
                165                 170                 175     
Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg
            180                 185                 190         
Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser
        195                 200                 205             
Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala
    210                 215                 220                 
Ala Thr Ser Ala Asn Leu
225                 230 


<210> 357
<211> 785
<212> PRT
<213> Homo sapiens

<400> 357
Met Pro Gly Val Ile Pro Ser Glu Ser Asn Gly Leu Ser Arg Gly Ser
 1               5                  10                  15      
Pro Ser Lys Lys Asn Arg Leu Ser Leu Lys Phe Phe Gln Lys Lys Glu
            20                  25                  30          
Thr Lys Arg Ala Leu Asp Phe Thr Asp Ser Gln Glu Asn Glu Glu Lys
        35                  40                  45              
Ala Ser Glu Tyr Arg Ala Ser Glu Ile Asp Gln Val Val Pro Ala Ala
    50                  55                  60                  
Gln Ser Ser Pro Ile Asn Cys Glu Lys Arg Glu Asn Leu Leu Pro Phe
65                  70                  75                  80  
Val Gly Leu Asn Asn Leu Gly Asn Thr Cys Tyr Leu Asn Ser Ile Leu
                85                  90                  95      
Gln Val Leu Tyr Phe Cys Pro Gly Phe Lys Ser Gly Val Lys His Leu
            100                 105                 110         
Phe Asn Ile Ile Ser Arg Lys Lys Glu Ala Leu Lys Asp Glu Ala Asn
        115                 120                 125             
Gln Lys Asp Lys Gly Asn Cys Lys Glu Asp Ser Leu Ala Ser Tyr Glu
    130                 135                 140                 
Leu Ile Cys Ser Leu Gln Ser Leu Ile Ile Ser Val Glu Gln Leu Gln
145                 150                 155                 160 
Ala Ser Phe Leu Leu Asn Pro Glu Lys Tyr Thr Asp Glu Leu Ala Thr
                165                 170                 175     
Gln Pro Arg Arg Leu Leu Asn Thr Leu Arg Glu Leu Asn Pro Met Tyr
            180                 185                 190         
Glu Gly Tyr Leu Gln His Asp Ala Gln Glu Val Leu Gln Cys Ile Leu
        195                 200                 205             
Gly Asn Ile Gln Glu Thr Cys Gln Leu Leu Lys Lys Glu Glu Val Lys
    210                 215                 220                 
Asn Val Ala Glu Leu Pro Thr Lys Val Glu Glu Ile Pro His Pro Lys
225                 230                 235                 240 
Glu Glu Met Asn Gly Ile Asn Ser Ile Glu Met Asp Ser Met Arg His
                245                 250                 255     
Ser Glu Asp Phe Lys Glu Lys Leu Pro Lys Gly Asn Gly Lys Arg Lys
            260                 265                 270         
Ser Asp Thr Glu Phe Gly Asn Met Lys Lys Lys Val Lys Leu Ser Lys
        275                 280                 285             
Glu His Gln Ser Leu Glu Glu Asn Gln Arg Gln Thr Arg Ser Lys Arg
    290                 295                 300                 
Lys Ala Thr Ser Asp Thr Leu Glu Ser Pro Pro Lys Ile Ile Pro Lys
305                 310                 315                 320 
Tyr Ile Ser Glu Asn Glu Ser Pro Arg Pro Ser Gln Lys Lys Ser Arg
                325                 330                 335     
Val Lys Ile Asn Trp Leu Lys Ser Ala Thr Lys Gln Pro Ser Ile Leu
            340                 345                 350         
Ser Lys Phe Cys Ser Leu Gly Lys Ile Thr Thr Asn Gln Gly Val Lys
        355                 360                 365             
Gly Gln Ser Lys Glu Asn Glu Cys Asp Pro Glu Glu Asp Leu Gly Lys
    370                 375                 380                 
Cys Glu Ser Asp Asn Thr Thr Asn Gly Cys Gly Leu Glu Ser Pro Gly
385                 390                 395                 400 
Asn Thr Val Thr Pro Val Asn Val Asn Glu Val Lys Pro Ile Asn Lys
                405                 410                 415     
Gly Glu Glu Gln Ile Gly Phe Glu Leu Val Glu Lys Leu Phe Gln Gly
            420                 425                 430         
Gln Leu Val Leu Arg Thr Arg Cys Leu Glu Cys Glu Ser Leu Thr Glu
        435                 440                 445             
Arg Arg Glu Asp Phe Gln Asp Ile Ser Val Pro Val Gln Glu Asp Glu
    450                 455                 460                 
Leu Ser Lys Val Glu Glu Ser Ser Glu Ile Ser Pro Glu Pro Lys Thr
465                 470                 475                 480 
Glu Met Lys Thr Leu Arg Trp Ala Ile Ser Gln Phe Ala Ser Val Glu
                485                 490                 495     
Arg Ile Val Gly Glu Asp Lys Tyr Phe Cys Glu Asn Cys His His Tyr
            500                 505                 510         
Thr Glu Ala Glu Arg Ser Leu Leu Phe Asp Lys Met Pro Glu Val Ile
        515                 520                 525             
Thr Ile His Leu Lys Cys Phe Ala Ala Ser Gly Leu Glu Phe Asp Cys
    530                 535                 540                 
Tyr Gly Gly Gly Leu Ser Lys Ile Asn Thr Pro Leu Leu Thr Pro Leu
545                 550                 555                 560 
Lys Leu Ser Leu Glu Glu Trp Ser Thr Lys Pro Thr Asn Asp Ser Tyr
                565                 570                 575     
Gly Leu Phe Ala Val Val Met His Ser Gly Ile Thr Ile Ser Ser Gly
            580                 585                 590         
His Tyr Thr Ala Ser Val Lys Val Thr Asp Leu Asn Ser Leu Glu Leu
        595                 600                 605             
Asp Lys Gly Asn Phe Val Val Asp Gln Met Cys Glu Met Gly Lys Pro
    610                 615                 620                 
Glu Pro Leu Asn Glu Glu Glu Ala Arg Gly Val Val Glu Asn Tyr Asn
625                 630                 635                 640 
Asp Glu Glu Val Ser Ile Arg Val Gly Gly Asn Thr Gln Pro Ser Lys
                645                 650                 655     
Val Leu Asn Lys Lys Asn Val Glu Ala Ile Gly Leu Leu Gly Gly Gln
            660                 665                 670         
Lys Ser Lys Ala Asp Tyr Glu Leu Tyr Asn Lys Ala Ser Asn Pro Asp
        675                 680                 685             
Lys Val Ala Ser Thr Ala Phe Ala Glu Asn Arg Asn Ser Glu Thr Ser
    690                 695                 700                 
Asp Thr Thr Gly Thr His Glu Ser Asp Arg Asn Lys Glu Ser Ser Asp
705                 710                 715                 720 
Gln Thr Gly Ile Asn Ile Ser Gly Phe Glu Asn Lys Ile Ser Tyr Val
                725                 730                 735     
Val Gln Ser Leu Lys Glu Tyr Glu Gly Lys Trp Leu Leu Phe Asp Asp
            740                 745                 750         
Ser Glu Val Lys Val Thr Glu Glu Lys Asp Phe Leu Asn Ser Leu Ser
        755                 760                 765             
Pro Ser Thr Ser Pro Thr Ser Thr Pro Tyr Leu Leu Phe Tyr Lys Lys
    770                 775                 780                 
Leu
785 


<210> 358
<211> 113
<212> PRT
<213> Homo sapiens

<400> 358
Ile Thr Leu Val Ser Ala Ala Pro Gly Lys Val Ile Cys Glu Met Lys
 1               5                  10                  15      
Val Glu Glu Glu His Thr Asn Ala Ile Gly Thr Leu His Gly Gly Leu
            20                  25                  30          
Thr Ala Thr Leu Val Asp Asn Ile Ser Thr Met Ala Leu Leu Cys Thr
        35                  40                  45              
Glu Arg Gly Ala Pro Gly Val Ser Val Asp Met Asn Ile Thr Tyr Met
    50                  55                  60                  
Ser Pro Ala Lys Leu Gly Glu Asp Ile Val Ile Thr Ala His Val Leu
65                  70                  75                  80  
Lys Gln Gly Lys Thr Leu Ala Phe Thr Ser Val Asp Leu Thr Asn Lys
                85                  90                  95      
Ala Thr Gly Lys Leu Ile Ala Gln Gly Arg His Thr Lys His Leu Gly
            100                 105                 110         
Asn
    


<210> 359
<211> 888
<212> PRT
<213> Homo sapiens

<400> 359
Lys Lys Ala Ile Thr Cys Gly Glu Lys Glu Lys Gln Asp Leu Ile Lys
 1               5                  10                  15      
Ser Leu Ala Met Leu Lys Asp Gly Phe Arg Thr Asp Arg Gly Ser His
            20                  25                  30          
Ser Asp Leu Trp Ser Ser Ser Ser Ser Leu Glu Ser Ser Ser Phe Pro
        35                  40                  45              
Leu Pro Lys Gln Tyr Leu Asp Val Ser Ser Gln Thr Asp Ile Ser Gly
    50                  55                  60                  
Ser Phe Gly Ile Asn Ser Asn Asn Gln Leu Ala Glu Lys Val Arg Leu
65                  70                  75                  80  
Arg Leu Arg Tyr Glu Glu Ala Lys Arg Arg Ile Ala Asn Leu Lys Ile
                85                  90                  95      
Gln Leu Ala Lys Leu Asp Ser Glu Ala Trp Pro Gly Val Leu Asp Ser
            100                 105                 110         
Glu Arg Asp Arg Leu Ile Leu Ile Asn Glu Lys Glu Glu Leu Leu Lys
        115                 120                 125             
Glu Met Arg Phe Ile Ser Pro Arg Lys Trp Thr Gln Gly Glu Val Glu
    130                 135                 140                 
Gln Leu Glu Met Ala Arg Lys Arg Leu Glu Lys Asp Leu Gln Ala Ala
145                 150                 155                 160 
Arg Asp Thr Gln Ser Lys Ala Leu Thr Glu Arg Leu Lys Leu Asn Ser
                165                 170                 175     
Lys Arg Asn Gln Leu Val Arg Glu Leu Glu Glu Ala Thr Arg Gln Val
            180                 185                 190         
Ala Thr Leu His Ser Gln Leu Lys Ser Leu Ser Ser Ser Met Gln Ser
        195                 200                 205             
Leu Ser Ser Gly Ser Ser Pro Gly Ser Leu Thr Ser Ser Arg Gly Ser
    210                 215                 220                 
Leu Val Ala Ser Ser Leu Asp Ser Ser Thr Ser Ala Ser Phe Thr Asp
225                 230                 235                 240 
Leu Tyr Tyr Asp Pro Phe Glu Gln Leu Asp Ser Glu Leu Gln Ser Lys
                245                 250                 255     
Val Glu Phe Leu Leu Leu Glu Gly Ala Thr Gly Phe Arg Pro Ser Gly
            260                 265                 270         
Cys Ile Thr Thr Ile His Glu Asp Glu Val Ala Lys Thr Gln Lys Ala
        275                 280                 285             
Glu Gly Gly Gly Arg Leu Gln Ala Leu Arg Ser Leu Ser Gly Thr Pro
    290                 295                 300                 
Lys Ser Met Thr Ser Leu Ser Pro Arg Ser Ser Leu Ser Ser Pro Ser
305                 310                 315                 320 
Pro Pro Cys Ser Pro Leu Met Ala Asp Pro Leu Leu Ala Gly Asp Ala
                325                 330                 335     
Phe Leu Asn Ser Leu Glu Phe Glu Asp Pro Glu Leu Ser Ala Thr Leu
            340                 345                 350         
Cys Glu Leu Ser Leu Gly Asn Ser Ala Gln Glu Arg Tyr Arg Leu Glu
        355                 360                 365             
Glu Pro Gly Thr Glu Gly Lys Gln Leu Gly Gln Ala Val Asn Thr Ala
    370                 375                 380                 
Gln Gly Cys Gly Leu Lys Val Ala Cys Val Ser Ala Ala Val Ser Asp
385                 390                 395                 400 
Glu Ser Val Ala Gly Asp Ser Gly Val Tyr Glu Ala Ser Val Gln Arg
                405                 410                 415     
Leu Gly Ala Ser Glu Ala Ala Ala Phe Asp Ser Asp Glu Ser Glu Ala
            420                 425                 430         
Val Gly Ala Thr Arg Ile Gln Ile Ala Leu Lys Tyr Asp Glu Lys Asn
        435                 440                 445             
Lys Gln Phe Ala Ile Leu Ile Ile Gln Leu Ser Asn Leu Ser Ala Leu
    450                 455                 460                 
Leu Gln Gln Gln Asp Gln Lys Val Asn Ile Arg Val Ala Val Leu Pro
465                 470                 475                 480 
Cys Ser Glu Ser Thr Thr Cys Leu Phe Arg Thr Arg Pro Leu Asp Ala
                485                 490                 495     
Ser Asp Thr Leu Val Phe Asn Glu Val Phe Trp Val Ser Met Ser Tyr
            500                 505                 510         
Pro Ala Leu His Gln Lys Thr Leu Arg Val Asp Val Cys Thr Thr Asp
        515                 520                 525             
Arg Ser His Leu Glu Glu Cys Leu Gly Gly Ala Gln Ile Ser Leu Ala
    530                 535                 540                 
Glu Val Cys Arg Ser Gly Glu Arg Ser Thr Arg Trp Tyr Asn Leu Leu
545                 550                 555                 560 
Ser Tyr Lys Tyr Leu Lys Lys Gln Ser Arg Glu Leu Lys Pro Val Gly
                565                 570                 575     
Val Met Ala Pro Ala Ser Gly Pro Ala Ser Thr Asp Ala Val Ser Ala
            580                 585                 590         
Leu Leu Glu Gln Thr Ala Val Glu Leu Glu Lys Arg Gln Glu Gly Arg
        595                 600                 605             
Ser Ser Thr Gln Thr Leu Glu Asp Ser Trp Arg Tyr Glu Glu Thr Ser
    610                 615                 620                 
Glu Asn Glu Ala Val Ala Glu Glu Glu Glu Glu Glu Val Glu Glu Glu
625                 630                 635                 640 
Glu Gly Glu Glu Asp Val Phe Thr Glu Lys Ala Ser Pro Asp Met Asp
                645                 650                 655     
Gly Tyr Pro Ala Leu Lys Val Asp Lys Glu Thr Asn Thr Glu Thr Pro
            660                 665                 670         
Ala Pro Ser Pro Thr Val Val Arg Pro Lys Asp Arg Arg Val Gly Thr
        675                 680                 685             
Pro Ser Gln Gly Pro Phe Leu Arg Gly Ser Thr Ile Ile Arg Ser Lys
    690                 695                 700                 
Thr Phe Ser Pro Gly Pro Gln Ser Gln Tyr Val Cys Arg Leu Asn Arg
705                 710                 715                 720 
Ser Asp Ser Asp Ser Ser Thr Leu Ser Lys Lys Pro Pro Phe Val Arg
                725                 730                 735     
Asn Ser Leu Glu Arg Arg Ser Val Arg Met Lys Arg Pro Ser Ser Val
            740                 745                 750         
Lys Ser Leu Arg Ser Glu Arg Leu Ile Arg Thr Ser Leu Asp Leu Glu
        755                 760                 765             
Leu Asp Leu Gln Ala Thr Arg Thr Trp His Ser Gln Leu Thr Gln Glu
    770                 775                 780                 
Ile Ser Val Leu Lys Glu Leu Lys Glu Gln Leu Glu Gln Ala Lys Ser
785                 790                 795                 800 
His Gly Glu Lys Glu Leu Pro Gln Trp Leu Arg Glu Asp Glu Arg Phe
                805                 810                 815     
Arg Leu Leu Leu Arg Met Leu Glu Lys Arg Met Asp Arg Ala Glu His
            820                 825                 830         
Lys Gly Glu Leu Gln Thr Asp Lys Met Met Arg Ala Ala Ala Lys Asp
        835                 840                 845             
Val His Arg Leu Arg Gly Gln Ser Cys Lys Glu Pro Pro Glu Val Gln
    850                 855                 860                 
Ser Phe Arg Glu Lys Met Ala Phe Phe Thr Arg Pro Arg Met Asn Ile
865                 870                 875                 880 
Pro Ala Leu Ser Ala Asp Asp Val
                885             


<210> 360
<211> 580
<212> PRT
<213> Homo sapiens

<400> 360
Pro Leu Val Ile Asn Thr Leu Lys Arg Phe Asn Leu Tyr Pro Glu Val
 1               5                  10                  15      
Ile Leu Ala Ser Trp Tyr Arg Ile Tyr Thr Lys Ile Met Asp Leu Ile
            20                  25                  30          
Gly Ile Gln Thr Lys Ile Cys Trp Thr Val Thr Arg Gly Glu Gly Leu
        35                  40                  45              
Ser Pro Ile Glu Ser Cys Glu Gly Leu Gly Asp Pro Ala Cys Phe Tyr
    50                  55                  60                  
Val Ala Val Ile Phe Ile Leu Asn Gly Leu Met Met Ala Leu Phe Phe
65                  70                  75                  80  
Ile Tyr Gly Thr Tyr Leu Ser Gly Ser Arg Leu Gly Gly Leu Val Thr
                85                  90                  95      
Val Leu Cys Phe Phe Phe Asn His Gly Glu Cys Thr Arg Val Met Trp
            100                 105                 110         
Thr Pro Pro Leu Arg Glu Ser Phe Ser Tyr Pro Phe Leu Val Leu Gln
        115                 120                 125             
Met Leu Leu Val Thr His Ile Leu Arg Ala Thr Lys Leu Tyr Arg Gly
    130                 135                 140                 
Ser Leu Ile Ala Leu Cys Ile Ser Asn Val Phe Phe Met Leu Pro Trp
145                 150                 155                 160 
Gln Phe Ala Gln Phe Val Leu Leu Thr Gln Ile Ala Ser Leu Phe Ala
                165                 170                 175     
Val Tyr Val Val Gly Tyr Ile Asp Ile Cys Lys Leu Arg Lys Ile Ile
            180                 185                 190         
Tyr Ile His Met Ile Ser Leu Ala Leu Cys Phe Val Leu Met Phe Gly
        195                 200                 205             
Asn Ser Met Leu Leu Thr Ser Tyr Tyr Ala Ser Ser Leu Val Ile Ile
    210                 215                 220                 
Trp Gly Ile Leu Ala Met Lys Pro His Phe Leu Lys Ile Asn Val Ser
225                 230                 235                 240 
Glu Leu Ser Leu Trp Val Ile Gln Gly Cys Phe Trp Leu Phe Gly Thr
                245                 250                 255     
Val Ile Leu Lys Tyr Leu Thr Ser Lys Ile Phe Gly Ile Ala Asp Asp
            260                 265                 270         
Ala His Ile Gly Asn Leu Leu Thr Ser Lys Phe Phe Ser Tyr Lys Asp
        275                 280                 285             
Phe Asp Thr Leu Leu Tyr Thr Cys Ala Ala Glu Phe Asp Phe Met Glu
    290                 295                 300                 
Lys Glu Thr Pro Leu Arg Tyr Thr Lys Thr Leu Leu Leu Pro Val Val
305                 310                 315                 320 
Leu Val Val Phe Val Ala Ile Val Arg Lys Ile Ile Ser Asp Met Trp
                325                 330                 335     
Gly Val Leu Ala Lys Gln Gln Thr His Val Arg Lys His Gln Phe Asp
            340                 345                 350         
His Gly Glu Leu Val Tyr His Ala Leu Gln Leu Leu Ala Tyr Thr Ala
        355                 360                 365             
Leu Gly Ile Leu Ile Met Arg Leu Lys Leu Phe Leu Thr Pro His Met
    370                 375                 380                 
Cys Val Met Ala Ser Leu Ile Cys Ser Arg Gln Leu Phe Gly Trp Leu
385                 390                 395                 400 
Phe Cys Lys Val His Pro Gly Ala Ile Val Phe Ala Ile Leu Ala Ala
                405                 410                 415     
Met Ser Ile Gln Gly Ser Ala Asn Leu Gln Thr Gln Trp Asn Ile Val
            420                 425                 430         
Gly Glu Phe Ser Asn Leu Pro Gln Glu Glu Leu Ile Glu Trp Ile Lys
        435                 440                 445             
Tyr Ser Thr Lys Pro Asp Ala Val Phe Ala Gly Ala Met Pro Thr Met
    450                 455                 460                 
Ala Ser Val Lys Leu Ser Ala Leu Arg Pro Ile Val Asn His Pro His
465                 470                 475                 480 
Tyr Glu Asp Ala Gly Leu Arg Ala Arg Thr Lys Ile Val Tyr Ser Met
                485                 490                 495     
Tyr Ser Arg Lys Ala Ala Glu Glu Val Lys Arg Glu Leu Ile Lys Leu
            500                 505                 510         
Lys Val Asn Tyr Tyr Ile Leu Glu Glu Ser Trp Cys Val Arg Arg Ser
        515                 520                 525             
Lys Pro Gly Cys Ser Met Pro Glu Ile Trp Asp Val Glu Asp Pro Ala
    530                 535                 540                 
Asn Ala Gly Lys Thr Pro Leu Cys Asn Leu Leu Val Lys Asp Ser Lys
545                 550                 555                 560 
Pro His Phe Thr Thr Val Phe Gln Asn Ser Val Tyr Lys Val Leu Glu
                565                 570                 575     
Val Val Lys Glu
            580 


<210> 361
<211> 506
<212> PRT
<213> Homo sapiens

<400> 361
Ala Met Gly Arg Val Val Ala Glu Leu Val Ser Ser Leu Leu Gly Leu
 1               5                  10                  15      
Trp Leu Leu Leu Cys Ser Cys Gly Cys Pro Glu Gly Ala Glu Leu Arg
            20                  25                  30          
Ala Pro Pro Asp Lys Ile Ala Ile Ile Gly Ala Gly Ile Gly Gly Thr
        35                  40                  45              
Ser Ala Ala Tyr Tyr Leu Arg Gln Lys Phe Gly Lys Asp Val Lys Ile
    50                  55                  60                  
Asp Leu Phe Glu Arg Glu Glu Val Gly Gly Arg Leu Ala Thr Met Met
65                  70                  75                  80  
Val Gln Gly Gln Glu Tyr Glu Ala Gly Gly Ser Val Ile His Pro Leu
                85                  90                  95      
Asn Leu His Met Lys Arg Phe Val Lys Asp Leu Gly Leu Ser Ala Val
            100                 105                 110         
Gln Ala Ser Gly Gly Leu Leu Gly Ile Tyr Asn Gly Glu Thr Leu Val
        115                 120                 125             
Phe Glu Glu Ser Asn Trp Phe Ile Ile Asn Val Ile Lys Leu Val Trp
    130                 135                 140                 
Arg Tyr Gly Phe Gln Phe Leu Arg Met His Met Trp Val Glu Asp Val
145                 150                 155                 160 
Leu Asp Lys Phe Met Arg Ile Tyr Arg Tyr Gln Ser His Asp Tyr Ala
                165                 170                 175     
Phe Ser Ser Val Glu Lys Leu Leu His Ala Leu Gly Gly Asp Asp Phe
            180                 185                 190         
Leu Gly Met Leu Asn Arg Thr Leu Leu Glu Thr Leu Gln Lys Ala Gly
        195                 200                 205             
Phe Ser Glu Lys Phe Leu Asn Glu Met Ile Ala Pro Val Met Arg Val
    210                 215                 220                 
Asn Tyr Gly Gln Ser Thr Asp Ile Asn Ala Phe Val Gly Ala Val Ser
225                 230                 235                 240 
Leu Ser Cys Ser Asp Ser Gly Leu Trp Ala Val Glu Gly Gly Asn Lys
                245                 250                 255     
Leu Val Cys Ser Gly Leu Leu Gln Ala Ser Lys Ser Asn Leu Ile Ser
            260                 265                 270         
Gly Ser Val Met Tyr Ile Glu Glu Lys Thr Lys Thr Lys Tyr Thr Gly
        275                 280                 285             
Asn Pro Thr Lys Met Tyr Glu Val Val Tyr Gln Ile Gly Thr Glu Thr
    290                 295                 300                 
Arg Ser Asp Phe Tyr Asp Ile Val Leu Val Ala Thr Pro Leu Asn Arg
305                 310                 315                 320 
Lys Met Ser Asn Ile Thr Phe Leu Asn Phe Asp Pro Pro Ile Glu Glu
                325                 330                 335     
Phe His Gln Tyr Tyr Gln His Ile Val Thr Thr Leu Val Lys Gly Glu
            340                 345                 350         
Leu Asn Thr Ser Ile Phe Ser Ser Arg Pro Ile Asp Lys Phe Gly Leu
        355                 360                 365             
Asn Thr Val Leu Thr Thr Asp Asn Ser Asp Leu Phe Ile Asn Ser Ile
    370                 375                 380                 
Gly Ile Val Pro Ser Val Arg Glu Lys Glu Asp Pro Glu Pro Ser Thr
385                 390                 395                 400 
Asp Gly Thr Tyr Val Trp Lys Ile Phe Ser Gln Glu Thr Leu Thr Lys
                405                 410                 415     
Ala Gln Ile Leu Lys Leu Phe Leu Ser Tyr Asp Tyr Ala Val Lys Lys
            420                 425                 430         
Pro Trp Leu Ala Tyr Pro His Tyr Lys Pro Pro Glu Lys Cys Pro Ser
        435                 440                 445             
Ile Ile Leu His Asp Arg Leu Tyr Tyr Leu Asn Gly Ile Glu Cys Ala
    450                 455                 460                 
Ala Ser Ala Met Glu Met Ser Ala Ile Ala Ala His Asn Ala Ala Leu
465                 470                 475                 480 
Leu Ala Tyr His Arg Trp Asn Gly His Thr Asp Met Ile Asp Gln Asp
                485                 490                 495     
Gly Leu Tyr Glu Lys Leu Lys Thr Glu Leu
            500                 505     


<210> 362
<211> 30
<212> PRT
<213> Homo sapiens

<400> 362
Met Arg Pro Arg Leu Trp Leu Leu Leu Ala Ala Gln Leu Thr Gly Arg
 1               5                  10                  15      
Arg Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Phe Tyr Lys
            20                  25                  30  


<210> 363
<211> 362
<212> PRT
<213> Homo sapiens

<400> 363
Met Arg Arg Pro Ser Leu Leu Leu Lys Asp Ile Leu Lys Cys Thr Leu
 1               5                  10                  15      
Leu Val Phe Gly Val Trp Ile Leu Tyr Ile Leu Lys Leu Asn Tyr Thr
            20                  25                  30          
Thr Glu Glu Cys Asp Met Lys Lys Met His Tyr Val Asp Pro Asp His
        35                  40                  45              
Val Lys Arg Ala Gln Lys Tyr Ala Gln Gln Val Leu Gln Lys Glu Cys
    50                  55                  60                  
Arg Pro Lys Phe Ala Lys Thr Ser Met Ala Leu Leu Phe Glu His Arg
65                  70                  75                  80  
Tyr Ser Val Asp Leu Leu Pro Phe Val Gln Lys Ala Pro Lys Asp Ser
                85                  90                  95      
Glu Ala Glu Ser Lys Tyr Asp Pro Pro Phe Gly Phe Arg Lys Phe Ser
            100                 105                 110         
Ser Lys Val Gln Thr Leu Leu Glu Leu Leu Pro Glu His Asp Leu Pro
        115                 120                 125             
Glu His Leu Lys Ala Lys Thr Cys Arg Arg Cys Val Val Ile Gly Ser
    130                 135                 140                 
Gly Gly Ile Leu His Gly Leu Glu Leu Gly His Thr Leu Asn Gln Phe
145                 150                 155                 160 
Asp Val Val Ile Arg Leu Asn Ser Ala Pro Val Glu Gly Tyr Ser Glu
                165                 170                 175     
His Val Gly Asn Lys Thr Thr Ile Arg Met Thr Tyr Pro Glu Gly Ala
            180                 185                 190         
Pro Leu Ser Asp Leu Glu Tyr Tyr Ser Asn Asp Leu Phe Val Ala Val
        195                 200                 205             
Leu Phe Lys Ser Val Asp Phe Asn Trp Leu Gln Ala Met Val Lys Lys
    210                 215                 220                 
Glu Thr Leu Pro Phe Trp Val Arg Leu Phe Phe Trp Lys Gln Val Ala
225                 230                 235                 240 
Glu Lys Ile Pro Leu Gln Pro Lys His Phe Arg Ile Leu Asn Pro Val
                245                 250                 255     
Ile Ile Lys Glu Thr Ala Phe Asp Ile Leu Gln Tyr Ser Glu Pro Gln
            260                 265                 270         
Ser Arg Phe Trp Gly Arg Asp Lys Asn Val Pro Thr Ile Gly Val Ile
        275                 280                 285             
Ala Val Val Leu Ala Thr His Leu Cys Asp Glu Val Ser Leu Ala Gly
    290                 295                 300                 
Phe Gly Tyr Asp Leu Asn Gln Pro Arg Thr Pro Leu His Tyr Phe Asp
305                 310                 315                 320 
Ser Gln Cys Met Ala Ala Met Asn Phe Gln Thr Met His Asn Val Thr
                325                 330                 335     
Thr Glu Thr Lys Phe Leu Leu Lys Leu Val Lys Glu Gly Val Val Lys
            340                 345                 350         
Asp Leu Ser Gly Gly Ile Asp Arg Glu Phe
        355                 360         


<210> 364
<211> 80
<212> PRT
<213> Homo sapiens

<400> 364
Leu Glu Pro Leu Ala Glu Asp Ile Leu His Gln Ser Pro Asn Met Asn
 1               5                  10                  15      
Ala Val Ile Ser Leu Gln Lys Ile Ile Glu Ile Gln Lys Leu Leu Val
            20                  25                  30          
Ser Leu Trp Lys Arg Ser Gln Pro Cys Glu Val Pro Ser Pro Pro Leu
        35                  40                  45              
Ile Phe Pro Val Cys Asp Ile Ile Val Tyr Pro Pro Thr Pro Val Pro
    50                  55                  60                  
Ser Asp Met Ser Cys Leu Leu Pro Gly Trp His Arg Phe Asn Gly Thr
65                  70                  75                  80  


<210> 365
<211> 209
<212> PRT
<213> Homo sapiens

<400> 365
Met Gly Asn Gly Lys Ser Ile Ala Gly Asp Gln Lys Ala Val Pro Thr
 1               5                  10                  15      
Gln Glu Thr His Val Trp Tyr Arg Thr Phe Met Met Glu Tyr Pro Ser
            20                  25                  30          
Gly Leu Gln Thr Leu His Glu Phe Lys Thr Leu Leu Gly Leu Gln Gly
        35                  40                  45              
Leu Asn Gln Lys Ala Asn Lys His Ile Asp Gln Val Tyr Asn Thr Phe
    50                  55                  60                  
Asp Thr Asn Lys Asp Gly Phe Ile Asp Phe Leu Glu Phe Ile Ala Ala
65                  70                  75                  80  
Val Asn Leu Ile Met Gln Glu Lys Met Glu Gln Lys Leu Lys Trp Tyr
                85                  90                  95      
Phe Lys Leu Tyr Asp Ala Asp Gly Asn Gly Ser Ile Asp Lys Asn Glu
            100                 105                 110         
Leu Leu Asp Met Phe Met Ala Val Gln Ala Leu Asn Gly Gln Gln Thr
        115                 120                 125             
Leu Ser Pro Glu Glu Phe Ile Asn Leu Val Phe His Lys Ile Asp Ile
    130                 135                 140                 
Asn Asn Asp Gly Glu Leu Thr Leu Glu Glu Phe Ile Asn Gly Met Ala
145                 150                 155                 160 
Lys Asp Gln Asp Leu Leu Glu Ile Val Tyr Lys Ser Phe Asp Phe Ser
                165                 170                 175     
Asn Val Leu Arg Val Ile Cys Asn Gly Lys Gln Pro Asp Met Glu Thr
            180                 185                 190         
Asp Ser Ser Lys Ser Pro Asp Lys Ala Gly Leu Gly Lys Val Lys Met
        195                 200                 205             
Lys
    


<210> 366
<211> 199
<212> PRT
<213> Homo sapiens

<400> 366
Lys Ile Asp Ala Thr Gln Val Glu Val Asn Pro Phe Gly Glu Thr Pro
 1               5                  10                  15      
Glu Gly Gln Val Val Cys Phe Asp Ala Lys Ile Asn Phe Asp Asp Asn
            20                  25                  30          
Ala Glu Phe Arg Gln Lys Asp Ile Phe Ala Met Asp Asp Lys Ser Glu
        35                  40                  45              
Asn Glu Pro Ile Glu Asn Glu Ala Ala Lys Tyr Asp Leu Lys Tyr Ile
    50                  55                  60                  
Gly Leu Asp Gly Asn Ile Ala Cys Phe Val Asn Gly Ala Gly Leu Ala
65                  70                  75                  80  
Met Ala Thr Cys Asp Ile Ile Phe Leu Asn Gly Gly Lys Pro Ala Asn
                85                  90                  95      
Phe Leu Asp Leu Gly Gly Gly Val Lys Glu Ala Gln Val Tyr Gln Ala
            100                 105                 110         
Phe Lys Leu Leu Thr Ala Asp Pro Lys Val Glu Ala Ile Leu Val Asn
        115                 120                 125             
Ile Phe Gly Gly Ile Val Asn Cys Ala Ile Ile Ala Asn Gly Ile Thr
    130                 135                 140                 
Lys Ala Cys Arg Glu Leu Glu Leu Lys Val Pro Leu Val Val Arg Leu
145                 150                 155                 160 
Glu Gly Thr Asn Val Gln Glu Ala Gln Lys Ile Leu Asn Asn Ser Gly
                165                 170                 175     
Leu Pro Ile Thr Ser Ala Ile Asp Leu Glu Asp Ala Ala Lys Lys Ala
            180                 185                 190         
Val Ala Ser Val Ala Lys Lys
        195                 


<210> 367
<211> 190
<212> PRT
<213> Homo sapiens

<400> 367
Met Lys His Val Lys Lys Glu Lys Ala Glu Lys Leu Glu Lys Glu Arg
 1               5                  10                  15      
Gln Arg His Ile Gly Lys Pro Leu Leu Gly Gly Pro Phe Ser Leu Thr
            20                  25                  30          
Thr His Thr Gly Glu Arg Lys Thr Asp Lys Asp Tyr Leu Gly Gln Trp
        35                  40                  45              
Leu Leu Ile Tyr Phe Gly Phe Thr His Cys Pro Asp Val Cys Pro Glu
    50                  55                  60                  
Glu Leu Glu Lys Met Ile Gln Val Val Asp Glu Ile Asp Ser Ile Thr
65                  70                  75                  80  
Thr Leu Pro Asp Leu Thr Pro Leu Phe Ile Ser Ile Asp Pro Glu Arg
                85                  90                  95      
Asp Thr Lys Glu Ala Ile Ala Asn Tyr Val Lys Glu Phe Ser Pro Lys
            100                 105                 110         
Leu Val Gly Leu Thr Gly Thr Arg Glu Glu Val Asp Gln Val Ala Arg
        115                 120                 125             
Ala Tyr Arg Val Tyr Tyr Ser Pro Gly Pro Lys Asp Glu Asp Glu Asp
    130                 135                 140                 
Tyr Ile Val Asp His Thr Ile Ile Met Tyr Leu Ile Gly Pro Asp Gly
145                 150                 155                 160 
Glu Phe Leu Asp Tyr Phe Gly Gln Asn Lys Arg Lys Gly Glu Ile Ala
                165                 170                 175     
Ala Ser Ile Ala Thr His Met Arg Pro Tyr Arg Lys Lys Ser
            180                 185                 190 


<210> 368
<211> 718
<212> PRT
<213> Homo sapiens

<400> 368
Met Glu Asp Leu Gly Glu Asn Thr Met Val Leu Ser Thr Leu Arg Ser
 1               5                  10                  15      
Leu Asn Asn Phe Ile Ser Gln Arg Val Glu Gly Gly Ser Gly Leu Asp
            20                  25                  30          
Ile Ser Thr Ser Ala Pro Gly Ser Leu Gln Met Gln Tyr Gln Gln Ser
        35                  40                  45              
Met Gln Leu Glu Glu Arg Ala Glu Gln Ile Arg Ser Lys Ser His Leu
    50                  55                  60                  
Ile Gln Val Glu Arg Glu Lys Met Gln Met Glu Leu Ser His Lys Arg
65                  70                  75                  80  
Ala Arg Val Glu Leu Glu Arg Ala Ala Ser Thr Ser Ala Arg Asn Tyr
                85                  90                  95      
Glu Arg Glu Val Asp Arg Asn Gln Glu Leu Leu Thr Arg Ile Arg Gln
            100                 105                 110         
Leu Gln Glu Arg Glu Ala Gly Ala Glu Glu Lys Met Gln Glu Gln Leu
        115                 120                 125             
Glu Arg Asn Arg Gln Cys Gln Gln Asn Leu Asp Ala Ala Ser Lys Arg
    130                 135                 140                 
Leu Arg Glu Lys Glu Asp Ser Leu Ala Gln Ala Gly Glu Thr Ile Asn
145                 150                 155                 160 
Ala Leu Lys Gly Arg Ile Ser Glu Leu Gln Trp Ser Val Met Asp Gln
                165                 170                 175     
Glu Met Arg Val Lys Arg Leu Glu Ser Glu Lys Gln Glu Leu Gln Glu
            180                 185                 190         
Gln Leu Asp Leu Gln His Lys Lys Cys Gln Glu Ala Asn Gln Lys Ile
        195                 200                 205             
Gln Glu Leu Gln Ala Ser Gln Glu Ala Arg Ala Asp His Glu Gln Gln
    210                 215                 220                 
Ile Lys Asp Leu Glu Gln Lys Leu Ser Leu Gln Glu Gln Asp Ala Ala
225                 230                 235                 240 
Ile Val Lys Asn Met Lys Ser Glu Leu Val Arg Leu Pro Arg Leu Glu
                245                 250                 255     
Arg Glu Leu Lys Gln Leu Arg Glu Glu Ser Ala His Leu Arg Glu Met
            260                 265                 270         
Arg Glu Thr Asn Gly Leu Leu Gln Glu Glu Leu Glu Gly Leu Gln Arg
        275                 280                 285             
Lys Leu Gly Arg Gln Glu Lys Met Gln Glu Thr Leu Val Gly Leu Glu
    290                 295                 300                 
Leu Glu Asn Glu Arg Leu Leu Ala Lys Leu Gln Ser Trp Glu Arg Leu
305                 310                 315                 320 
Asp Gln Thr Met Gly Leu Ser Ile Arg Thr Pro Glu Asp Leu Ser Arg
                325                 330                 335     
Phe Val Val Glu Leu Gln Gln Arg Glu Leu Ala Leu Lys Asp Lys Asn
            340                 345                 350         
Ser Ala Val Thr Ser Ser Ala Arg Gly Leu Glu Lys Ala Arg Gln Gln
        355                 360                 365             
Leu Gln Glu Glu Leu Arg Gln Val Ser Gly Gln Leu Leu Glu Glu Arg
    370                 375                 380                 
Lys Lys Arg Glu Thr His Glu Ala Leu Ala Arg Arg Leu Gln Lys Arg
385                 390                 395                 400 
Val Leu Leu Leu Thr Lys Glu Arg Asp Gly Met Arg Ala Ile Leu Gly
                405                 410                 415     
Ser Tyr Asp Ser Glu Leu Thr Pro Ala Glu Tyr Ser Pro Gln Leu Thr
            420                 425                 430         
Arg Arg Met Arg Glu Ala Glu Asp Met Val Gln Lys Val His Ser His
        435                 440                 445             
Ser Ala Glu Met Glu Ala Gln Leu Ser Gln Ala Leu Glu Glu Leu Gly
    450                 455                 460                 
Gly Gln Lys Gln Arg Ala Asp Met Leu Glu Met Glu Leu Lys Met Leu
465                 470                 475                 480 
Lys Ser Gln Ser Ser Ser Ala Glu Gln Ser Phe Leu Phe Ser Arg Glu
                485                 490                 495     
Glu Ala Asp Thr Leu Arg Leu Lys Val Glu Glu Leu Glu Gly Glu Arg
            500                 505                 510         
Ser Arg Leu Glu Glu Glu Lys Arg Met Leu Glu Ala Gln Leu Glu Arg
        515                 520                 525             
Arg Ala Leu Gln Gly Asp Tyr Asp Gln Ser Arg Thr Lys Val Leu His
    530                 535                 540                 
Met Ser Leu Asn Pro Thr Ser Val Ala Arg Gln Arg Leu Arg Glu Asp
545                 550                 555                 560 
His Ser Gln Leu Gln Ala Glu Cys Glu Arg Leu Arg Gly Leu Leu Arg
                565                 570                 575     
Ala Met Glu Arg Gly Gly Thr Val Pro Ala Asp Leu Glu Ala Ala Ala
            580                 585                 590         
Ala Ser Leu Pro Ser Ser Lys Glu Val Ala Glu Leu Lys Lys Gln Val
        595                 600                 605             
Glu Ser Ala Glu Leu Lys Asn Gln Arg Leu Lys Glu Val Phe Gln Thr
    610                 615                 620                 
Lys Ile Gln Glu Phe Arg Lys Ala Cys Tyr Thr Leu Thr Gly Tyr Gln
625                 630                 635                 640 
Ile Asp Ile Thr Thr Glu Asn Gln Tyr Arg Leu Thr Ser Leu Tyr Ala
                645                 650                 655     
Glu His Pro Gly Asp Cys Leu Ile Phe Lys Ala Thr Ser Pro Ser Gly
            660                 665                 670         
Ser Lys Met Gln Leu Leu Glu Thr Glu Phe Ser His Thr Val Gly Glu
        675                 680                 685             
Leu Ile Glu Val His Leu Arg Arg Gln Asp Ser Ile Pro Ala Phe Leu
    690                 695                 700                 
Ser Ser Leu Thr Leu Glu Leu Phe Ser Arg Gln Thr Val Ala
705                 710                 715             


<210> 369
<211> 310
<212> PRT
<213> Homo sapiens

<400> 369
Met Arg Glu Trp Asp Gly Val Phe Gln Asn Glu Val Glu Lys Gly Glu
 1               5                  10                  15      
Ile Ser Ser Val Lys Asn His Asp Gly Glu Asp Asn Ile Ile Ala Trp
            20                  25                  30          
Ile Ser Phe Arg Met Phe Gly Pro Gly Arg Glu Tyr Asn Phe Thr Arg
        35                  40                  45              
Pro Asn Glu Lys Gly Glu Tyr Glu Ile Ala Glu Gly Ile Ser Ala Thr
    50                  55                  60                  
Val Phe Arg Thr Val Leu Asp Tyr Tyr Lys Thr Gly Ile Ile Asn Cys
65                  70                  75                  80  
Pro Asp Gly Ile Ser Ile Pro Asp Leu Arg Asp Thr Cys Asp Tyr Leu
                85                  90                  95      
Cys Ile Asn Phe Asp Phe Asn Thr Ile Arg Cys Gln Asp Leu Ser Ala
            100                 105                 110         
Leu Leu His Glu Leu Ser Asn Asp Gly Ala His Lys Gln Phe Asp His
        115                 120                 125             
Tyr Leu Glu Glu Leu Ile Leu Pro Ile Met Val Gly Cys Ala Lys Lys
    130                 135                 140                 
Gly Glu Arg Glu Cys His Ile Val Val Leu Thr Asp Glu Asp Ser Val
145                 150                 155                 160 
Asp Trp Asp Glu Asp His Pro Pro Pro Met Gly Glu Glu Tyr Ser Gln
                165                 170                 175     
Ile Leu Tyr Ser Ser Lys Leu Tyr Arg Phe Phe Lys Tyr Ile Glu Asn
            180                 185                 190         
Arg Asp Val Ala Lys Thr Val Leu Lys Glu Arg Gly Leu Lys Asn Ile
        195                 200                 205             
Arg Ile Gly Ile Glu Gly Tyr Pro Thr Cys Lys Glu Lys Ile Lys Arg
    210                 215                 220                 
Arg Pro Gly Gly Arg Ser Glu Val Ile Tyr Asn Tyr Val Gln Arg Pro
225                 230                 235                 240 
Phe Ile Gln Met Ser Trp Glu Lys Glu Glu Gly Lys Ser Arg His Val
                245                 250                 255     
Asp Phe Gln Cys Val Arg Ser Lys Ser Leu Thr Asn Leu Val Ala Ala
            260                 265                 270         
Gly Asp Asp Val Leu Glu Asp Gln Glu Ile Leu Met His His Pro Pro
        275                 280                 285             
Gln Val Asp Glu Leu Asp Arg Leu Asn Ala Pro Leu Ser Gln Met Ala
    290                 295                 300                 
Ser Asn Asp Phe Gln Asp
305                 310 


<210> 370
<211> 681
<212> PRT
<213> Homo sapiens

<400> 370
Met Gly Ser Pro Val His Arg Val Ser Leu Gly Asp Thr Trp Ser Arg
 1               5                  10                  15      
Gln Met His Pro Asp Ile Glu Ser Glu Arg Tyr Met Gln Ser Phe Asp
            20                  25                  30          
Val Glu Arg Leu Thr Asn Ile Leu Asp Gly Gly Ala Gln Asn Thr Ala
        35                  40                  45              
Leu Arg Arg Lys Val Glu Ser Ile Ile His Ser Tyr Pro Glu Phe Ser
    50                  55                  60                  
Cys Lys Asp Asn Tyr Phe Met Thr Gln Asn Glu Arg Tyr Lys Ala Ala
65                  70                  75                  80  
Met Arg Arg Ala Phe His Ile Arg Leu Ile Ala Arg Arg Leu Gly Trp
                85                  90                  95      
Leu Glu Asp Gly Arg Glu Leu Gly Tyr Ala Tyr Arg Ala Leu Ser Gly
            100                 105                 110         
Asp Val Ala Leu Asn Ile His Arg Val Phe Val Arg Ala Leu Arg Ser
        115                 120                 125             
Leu Gly Ser Glu Glu Gln Ile Ala Lys Trp Asp Pro Leu Cys Lys Asn
    130                 135                 140                 
Ile Gln Ile Ile Ala Thr Tyr Ala Gln Thr Glu Leu Gly His Gly Thr
145                 150                 155                 160 
Tyr Leu Gln Gly Leu Glu Thr Glu Ala Thr Tyr Asp Ala Ala Thr Gln
                165                 170                 175     
Glu Phe Val Ile His Ser Pro Thr Leu Thr Ala Thr Lys Trp Trp Pro
            180                 185                 190         
Gly Asp Leu Gly Arg Ser Ala Thr His Ala Leu Val Gln Ala Gln Leu
        195                 200                 205             
Ile Cys Ser Gly Ala Arg Arg Gly Met His Ala Phe Ile Val Pro Ile
    210                 215                 220                 
Arg Ser Leu Gln Asp His Thr Pro Leu Pro Gly Ile Ile Ile Gly Asp
225                 230                 235                 240 
Ile Gly Pro Lys Met Asp Phe Asp Gln Thr Asp Asn Gly Phe Leu Gln
                245                 250                 255     
Leu Asn His Val Arg Val Pro Arg Glu Asn Met Leu Ser Arg Phe Ala
            260                 265                 270         
Gln Val Leu Pro Asp Gly Thr Tyr Val Lys Leu Gly Thr Ala Gln Ser
        275                 280                 285             
Asn Tyr Leu Pro Met Val Val Val Arg Val Glu Leu Leu Ser Gly Glu
    290                 295                 300                 
Ile Leu Pro Ile Leu Gln Lys Ala Cys Val Ile Ala Met Arg Tyr Ser
305                 310                 315                 320 
Val Ile Arg Arg Gln Ser Arg Leu Arg Pro Ser Asp Pro Glu Ala Lys
                325                 330                 335     
Val Leu Asp Tyr Gln Thr Gln Gln Gln Lys Leu Phe Pro Gln Leu Ala
            340                 345                 350         
Ile Ser Tyr Ala Phe His Phe Leu Ala Val Ser Leu Leu Glu Phe Phe
        355                 360                 365             
Gln His Ser Tyr Thr Ala Ile Leu Asn Gln Asp Phe Ser Phe Leu Pro
    370                 375                 380                 
Glu Leu His Ala Leu Ser Thr Gly Met Lys Ala Met Met Ser Glu Phe
385                 390                 395                 400 
Cys Thr Gln Gly Ala Glu Met Cys Arg Arg Ala Cys Gly Gly His Gly
                405                 410                 415     
Tyr Ser Lys Leu Ser Gly Leu Pro Ser Leu Val Thr Lys Leu Ser Ala
            420                 425                 430         
Ser Cys Thr Tyr Glu Gly Glu Asn Thr Val Leu Tyr Leu Gln Val Ala
        435                 440                 445             
Arg Phe Leu Val Lys Ser Tyr Leu Gln Thr Gln Met Ser Pro Gly Ser
    450                 455                 460                 
Thr Pro Gln Arg Ser Leu Ser Pro Ser Val Ala Tyr Leu Thr Ala Pro
465                 470                 475                 480 
Asp Leu Ala Arg Cys Pro Ala Gln Arg Ala Ala Asp Phe Leu Cys Pro
                485                 490                 495     
Glu Leu Tyr Thr Thr Ala Trp Ala His Val Ala Val Arg Leu Ile Lys
            500                 505                 510         
Asp Ser Val Gln His Leu Gln Thr Leu Thr Gln Ser Gly Ala Asp Gln
        515                 520                 525             
His Glu Ala Trp Asn Gln Thr Thr Val Ile His Leu Gln Ala Ala Lys
    530                 535                 540                 
Val His Cys Tyr Tyr Val Thr Val Lys Gly Phe Thr Glu Ala Leu Glu
545                 550                 555                 560 
Lys Leu Glu Asn Glu Pro Ala Ile Gln Gln Val Leu Lys Arg Leu Cys
                565                 570                 575     
Asp Leu His Ala Ile His Gly Ile Leu Thr Asn Ser Gly Asp Phe Leu
            580                 585                 590         
His Asp Ala Phe Leu Ser Gly Ala Gln Val Asp Met Ala Arg Thr Ala
        595                 600                 605             
Tyr Leu Asp Leu Leu Arg Leu Ile Arg Lys Asp Ala Ile Leu Leu Thr
    610                 615                 620                 
Asp Ala Phe Asp Phe Thr Asp Gln Cys Leu Asn Ser Ala Leu Gly Cys
625                 630                 635                 640 
Tyr Asp Gly Asn Val Tyr Glu Arg Leu Phe Gln Trp Ala Gln Lys Ser
                645                 650                 655     
Pro Thr Asn Thr Gln Glu Asn Pro Ala Tyr Glu Glu Tyr Ile Arg Pro
            660                 665                 670         
Leu Leu Gln Ser Trp Arg Ser Lys Leu
        675                 680     


<210> 371
<211> 461
<212> PRT
<213> Homo sapiens

<400> 371
Met Ala Ser Pro Ala Leu Ala Ala Ala Leu Ala Val Ala Ala Ala Ala
 1               5                  10                  15      
Gly Pro Asn Ala Ser Gly Ala Gly Glu Arg Gly Ser Gly Gly Val Ala
            20                  25                  30          
Asn Ala Ser Gly Ala Ser Trp Gly Pro Pro Arg Gly Gln Tyr Ser Ala
        35                  40                  45              
Gly Ala Val Ala Gly Leu Ala Ala Val Val Gly Phe Leu Ile Val Phe
    50                  55                  60                  
Thr Val Val Gly Asn Val Leu Val Val Ile Ala Val Leu Thr Ser Arg
65                  70                  75                  80  
Ala Leu Arg Ala Pro Gln Asn Leu Phe Leu Val Ser Leu Ala Ser Ala
                85                  90                  95      
Asp Ile Leu Val Ala Thr Leu Val Met Pro Phe Ser Leu Ala Asn Glu
            100                 105                 110         
Leu Met Ala Tyr Trp Tyr Phe Gly Gln Val Trp Cys Gly Val Tyr Leu
        115                 120                 125             
Ala Leu Asp Val Leu Phe Cys Thr Ser Ser Ile Val His Leu Cys Ala
    130                 135                 140                 
Ile Ser Leu Asp Arg Tyr Trp Ser Val Thr Gln Ala Val Glu Tyr Asn
145                 150                 155                 160 
Leu Lys Arg Thr Pro Arg Arg Val Lys Ala Thr Ile Val Ala Val Trp
                165                 170                 175     
Leu Ile Ser Ala Val Ile Ser Phe Pro Pro Leu Val Ser Leu Tyr Arg
            180                 185                 190         
Gln Pro Asp Gly Ala Ala Tyr Pro Gln Cys Gly Leu Asn Asp Glu Thr
        195                 200                 205             
Trp Tyr Ile Leu Ser Ser Cys Ile Gly Ser Phe Phe Ala Pro Cys Leu
    210                 215                 220                 
Ile Met Gly Leu Val Tyr Ala Arg Ile Tyr Arg Val Ala Lys Arg Arg
225                 230                 235                 240 
Thr Arg Thr Leu Ser Glu Lys Arg Ala Pro Val Gly Pro Asp Gly Ala
                245                 250                 255     
Ser Pro Thr Thr Glu Asn Gly Leu Gly Ala Ala Ala Gly Glu Ala Arg
            260                 265                 270         
Thr Gly Thr Ala Arg Pro Arg Pro Pro Thr Trp Ser Arg Thr Arg Ala
        275                 280                 285             
Ala Gln Arg Pro Arg Gly Gly Ala Pro Gly Pro Leu Arg Arg Gly Gly
    290                 295                 300                 
Arg Arg Arg Ala Gly Ala Glu Gly Gly Ala Gly Gly Ala Asp Gly Gln
305                 310                 315                 320 
Gly Ala Gly Pro Gly Ala Ala Gln Ser Gly Ala Leu Thr Ala Ser Arg
                325                 330                 335     
Ser Pro Gly Pro Gly Gly Arg Leu Ser Arg Ala Ser Ser Arg Ser Val
            340                 345                 350         
Glu Phe Phe Leu Ser Arg Arg Arg Arg Ala Arg Ser Ser Val Cys Arg
        355                 360                 365             
Arg Lys Val Ala Gln Ala Arg Glu Lys Arg Phe Thr Phe Val Leu Ala
    370                 375                 380                 
Val Val Met Gly Val Phe Val Leu Cys Trp Phe Pro Phe Phe Phe Ile
385                 390                 395                 400 
Tyr Ser Leu Tyr Gly Ile Cys Arg Glu Ala Cys Gln Val Pro Gly Pro
                405                 410                 415     
Leu Phe Lys Phe Phe Phe Trp Ile Gly Tyr Cys Asn Ser Ser Leu Asn
            420                 425                 430         
Pro Val Ile Tyr Thr Val Phe Asn Gln Asp Phe Arg Pro Ser Phe Lys
        435                 440                 445             
His Ile Leu Phe Arg Arg Arg Arg Arg Gly Phe Arg Gln
    450                 455                 460     


<210> 372
<211> 194
<212> PRT
<213> Homo sapiens

<400> 372
Met Glu Glu Lys Leu Lys Lys Thr Lys Ile Ile Phe Val Val Gly Gly
 1               5                  10                  15      
Pro Gly Ser Gly Lys Gly Thr Gln Cys Glu Lys Ile Val Gln Lys Tyr
            20                  25                  30          
Gly Tyr Thr His Leu Ser Thr Gly Asp Leu Leu Arg Ser Glu Val Ser
        35                  40                  45              
Ser Gly Ser Ala Arg Gly Lys Lys Leu Ser Glu Ile Met Glu Lys Gly
    50                  55                  60                  
Gln Leu Val Pro Leu Glu Thr Val Leu Asp Met Leu Arg Asp Ala Met
65                  70                  75                  80  
Val Ala Lys Val Asn Thr Ser Lys Gly Phe Leu Ile Asp Gly Tyr Pro
                85                  90                  95      
Arg Glu Val Gln Gln Gly Glu Glu Phe Glu Arg Arg Ile Gly Gln Pro
            100                 105                 110         
Thr Leu Leu Leu Tyr Val Asp Ala Gly Pro Glu Thr Met Thr Gln Arg
        115                 120                 125             
Leu Leu Lys Arg Gly Glu Thr Ser Gly Arg Val Asp Asp Asn Glu Glu
    130                 135                 140                 
Thr Ile Lys Lys Arg Leu Glu Thr Tyr Tyr Lys Ala Thr Glu Pro Val
145                 150                 155                 160 
Ile Ala Phe Tyr Glu Lys Arg Gly Ile Val Arg Lys Val Asn Ala Glu
                165                 170                 175     
Gly Ser Val Asp Ser Val Phe Ser Gln Val Cys Thr His Leu Asp Ala
            180                 185                 190         
Leu Lys
        


<210> 373
<211> 239
<212> PRT
<213> Homo sapiens

<400> 373
Met Ala Pro Ser Val Pro Ala Ala Glu Pro Glu Tyr Pro Lys Gly Ile
 1               5                  10                  15      
Arg Ala Val Leu Leu Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala
            20                  25                  30          
Pro Arg Leu Ala Glu Asn Phe Cys Val Cys His Leu Ala Thr Gly Asp
        35                  40                  45              
Met Leu Arg Ala Met Val Ala Ser Gly Ser Glu Leu Gly Lys Lys Leu
    50                  55                  60                  
Lys Ala Thr Met Asp Ala Gly Lys Leu Val Ser Asp Glu Met Val Val
65                  70                  75                  80  
Glu Leu Ile Glu Lys Asn Leu Glu Thr Pro Leu Cys Lys Asn Gly Phe
                85                  90                  95      
Leu Leu Asp Gly Phe Pro Arg Thr Val Arg Gln Ala Glu Met Leu Asp
            100                 105                 110         
Asp Leu Met Glu Lys Arg Lys Glu Lys Leu Asp Ser Val Ile Glu Phe
        115                 120                 125             
Ser Ile Pro Asp Ser Leu Leu Ile Arg Arg Ile Thr Gly Arg Leu Ile
    130                 135                 140                 
His Pro Lys Ser Gly Arg Ser Tyr His Glu Glu Phe Asn Pro Pro Lys
145                 150                 155                 160 
Glu Pro Met Lys Asp Asp Ile Thr Gly Glu Pro Leu Ile Arg Arg Ser
                165                 170                 175     
Asp Asp Asn Glu Lys Ala Leu Lys Ile Arg Leu Gln Ala Tyr His Thr
            180                 185                 190         
Gln Thr Thr Pro Leu Ile Glu Tyr Tyr Arg Lys Arg Gly Ile His Ser
        195                 200                 205             
Ala Ile Asp Ala Ser Gln Thr Pro Asp Val Val Phe Ala Ser Ile Leu
    210                 215                 220                 
Ala Ala Phe Ser Lys Ala Thr Cys Lys Asp Leu Val Met Phe Ile
225                 230                 235                 


<210> 374
<211> 297
<212> PRT
<213> Homo sapiens

<400> 374
Met Gly Asp His Ala Trp Ser Phe Leu Lys Asp Phe Leu Ala Gly Ala
 1               5                  10                  15      
Val Ala Ala Ala Val Ser Lys Thr Ala Val Ala Pro Ile Glu Arg Val
            20                  25                  30          
Lys Leu Leu Leu Gln Val Gln His Ala Ser Lys Gln Ile Ser Ala Glu
        35                  40                  45              
Lys Gln Tyr Lys Gly Ile Ile Asp Cys Val Val Arg Ile Pro Lys Glu
    50                  55                  60                  
Gln Gly Phe Leu Ser Phe Trp Arg Gly Asn Leu Ala Asn Val Ile Arg
65                  70                  75                  80  
Tyr Phe Pro Thr Gln Ala Leu Asn Phe Ala Phe Lys Asp Lys Tyr Lys
                85                  90                  95      
Gln Leu Phe Leu Gly Gly Val Asp Arg His Lys Gln Phe Trp Arg Tyr
            100                 105                 110         
Phe Ala Gly Asn Leu Ala Ser Gly Gly Ala Ala Gly Ala Thr Ser Leu
        115                 120                 125             
Cys Phe Val Tyr Pro Leu Asp Phe Ala Arg Thr Arg Leu Ala Ala Asp
    130                 135                 140                 
Val Gly Arg Arg Ala Gln Arg Glu Phe His Gly Leu Gly Asp Cys Ile
145                 150                 155                 160 
Ile Lys Ile Phe Lys Ser Asp Gly Leu Arg Gly Leu Tyr Gln Gly Phe
                165                 170                 175     
Asn Val Ser Val Gln Gly Ile Ile Ile Tyr Arg Ala Ala Tyr Phe Gly
            180                 185                 190         
Val Tyr Asp Thr Ala Lys Gly Met Leu Pro Asp Pro Lys Asn Val His
        195                 200                 205             
Ile Phe Val Ser Trp Met Ile Ala Gln Ser Val Thr Ala Val Ala Gly
    210                 215                 220                 
Leu Leu Ser Tyr Pro Phe Asp Thr Val Arg Arg Arg Met Met Met Gln
225                 230                 235                 240 
Ser Gly Arg Lys Gly Ala Asp Ile Met Tyr Thr Gly Thr Val Asp Cys
                245                 250                 255     
Trp Arg Lys Ile Ala Lys Asp Glu Gly Ala Lys Ala Phe Phe Lys Gly
            260                 265                 270         
Ala Trp Ser Asn Val Leu Arg Gly Met Gly Gly Ala Phe Val Leu Val
        275                 280                 285             
Leu Tyr Asp Glu Ile Lys Lys Tyr Val
    290                 295         


<210> 375
<211> 346
<212> PRT
<213> Homo sapiens

<400> 375
Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn
 1               5                  10                  15      
Glu Glu Gln Glu Tyr Val Gln Thr Val Lys Ser Ser Lys Gly Gly Pro
            20                  25                  30          
Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val
        35                  40                  45              
Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr
    50                  55                  60                  
Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile
65                  70                  75                  80  
Lys Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu
                85                  90                  95      
Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Leu Leu
            100                 105                 110         
Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys
        115                 120                 125             
Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Ala Ser Arg
    130                 135                 140                 
Thr Asn Lys Glu Ile Arg Asp Ile Asn Arg Val Tyr Arg Glu Glu Leu
145                 150                 155                 160 
Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe
                165                 170                 175     
Arg Asn Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp Phe
            180                 185                 190         
Gly Val Asn Glu Asp Leu Ala Asp Ser Asp Ala Arg Ala Leu Tyr Glu
        195                 200                 205             
Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Asn Thr Ile
    210                 215                 220                 
Leu Thr Thr Arg Ser Tyr Pro Gln Leu Arg Arg Val Phe Gln Lys Tyr
225                 230                 235                 240 
Thr Lys Tyr Ser Lys His Asp Met Asn Lys Val Leu Asp Leu Glu Leu
                245                 250                 255     
Lys Gly Asp Ile Glu Lys Cys Leu Thr Ala Ile Val Lys Cys Ala Thr
            260                 265                 270         
Ser Lys Pro Ala Phe Phe Ala Glu Lys Leu His Gln Ala Met Lys Gly
        275                 280                 285             
Val Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met Val Ser Arg Ser
    290                 295                 300                 
Glu Ile Asp Met Asn Asp Ile Lys Ala Phe Tyr Gln Lys Met Tyr Gly
305                 310                 315                 320 
Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu
                325                 330                 335     
Lys Ile Leu Val Ala Leu Cys Gly Gly Asn
            340                 345     


<210> 376
<211> 320
<212> PRT
<213> Homo sapiens

<400> 376
Met Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Pro Gly Phe Asp
 1               5                  10                  15      
Glu Arg Ala Asp Ala Glu Thr Leu Arg Lys Ala Met Lys Gly Leu Gly
            20                  25                  30          
Thr Asp Glu Glu Ser Ile Leu Thr Leu Leu Thr Ser Arg Ser Asn Ala
        35                  40                  45              
Gln Arg Gln Glu Ile Ser Ala Ala Phe Lys Thr Leu Phe Gly Arg Asp
    50                  55                  60                  
Leu Leu Asp Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu
65                  70                  75                  80  
Ile Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu
                85                  90                  95      
Lys His Ala Leu Lys Gly Ala Gly Thr Asn Glu Lys Val Leu Thr Glu
            100                 105                 110         
Ile Ile Ala Ser Arg Thr Pro Glu Glu Leu Arg Ala Ile Lys Gln Val
        115                 120                 125             
Tyr Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly Asp
    130                 135                 140                 
Thr Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn
145                 150                 155                 160 
Arg Asp Pro Asp Ala Gly Ile Asp Glu Ala Gln Val Glu Gln Asp Ala
                165                 170                 175     
Gln Ala Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Glu
            180                 185                 190         
Lys Phe Ile Thr Ile Phe Gly Thr Arg Ser Val Ser His Leu Arg Lys
        195                 200                 205             
Val Phe Asp Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu Thr
    210                 215                 220                 
Ile Asp Arg Glu Thr Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala Val
225                 230                 235                 240 
Val Lys Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr Leu Tyr
                245                 250                 255     
Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg Val
            260                 265                 270         
Met Val Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe
        275                 280                 285             
Arg Lys Asn Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp Thr
    290                 295                 300                 
Ser Gly Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu Asp Asp
305                 310                 315                 320 


<210> 377
<211> 466
<212> PRT
<213> Homo sapiens

<400> 377
Met Ser Tyr Pro Gly Tyr Pro Pro Thr Gly Tyr Pro Pro Phe Pro Gly
 1               5                  10                  15      
Tyr Pro Pro Ala Gly Gln Glu Ser Ser Phe Pro Pro Ser Gly Gln Tyr
            20                  25                  30          
Pro Tyr Pro Ser Gly Phe Pro Pro Met Gly Gly Gly Ala Tyr Pro Gln
        35                  40                  45              
Val Pro Ser Ser Gly Tyr Pro Gly Ala Gly Gly Tyr Pro Ala Pro Gly
    50                  55                  60                  
Gly Tyr Pro Ala Pro Gly Gly Tyr Pro Gly Ala Pro Gln Pro Gly Gly
65                  70                  75                  80  
Ala Pro Ser Tyr Pro Gly Val Pro Pro Gly Gln Gly Phe Gly Val Pro
                85                  90                  95      
Pro Gly Gly Ala Gly Phe Ser Gly Tyr Pro Gln Pro Pro Ser Gln Ser
            100                 105                 110         
Tyr Gly Gly Gly Pro Ala Gln Val Pro Leu Pro Gly Gly Phe Pro Gly
        115                 120                 125             
Gly Gln Met Pro Ser Gln Tyr Pro Gly Gly Gln Pro Thr Tyr Pro Ser
    130                 135                 140                 
Gln Pro Ala Thr Val Thr Gln Val Thr Gln Gly Thr Ile Arg Pro Ala
145                 150                 155                 160 
Ala Asn Phe Asp Ala Ile Arg Asp Ala Glu Ile Leu Arg Lys Ala Met
                165                 170                 175     
Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Val Asp Val Val Ala Asn
            180                 185                 190         
Arg Ser Asn Asp Gln Arg Gln Lys Ile Lys Ala Ala Phe Lys Thr Ser
        195                 200                 205             
Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser Glu Leu Ser Gly Asn
    210                 215                 220                 
Met Glu Glu Leu Ile Leu Ala Leu Phe Met Pro Pro Thr Tyr Tyr Asp
225                 230                 235                 240 
Ala Trp Ser Leu Arg Lys Ala Met Gln Gly Ala Gly Thr Gln Glu Arg
                245                 250                 255     
Val Leu Ile Glu Ile Leu Cys Thr Arg Thr Asn Gln Glu Ile Arg Glu
            260                 265                 270         
Ile Val Arg Cys Tyr Gln Ser Glu Phe Gly Arg Asp Leu Glu Lys Asp
        275                 280                 285             
Ile Arg Ser Asp Thr Ser Gly His Phe Glu Arg Leu Leu Val Ser Met
    290                 295                 300                 
Cys Gln Gly Asn Arg Asp Glu Asn Gln Ser Ile Asn His Gln Met Ala
305                 310                 315                 320 
Gln Glu Asp Ala Gln Arg Leu Tyr Gln Ala Gly Glu Gly Arg Leu Gly
                325                 330                 335     
Thr Asp Glu Ser Cys Phe Asn Met Ile Leu Ala Thr Arg Ser Phe Pro
            340                 345                 350         
Gln Leu Arg Ala Thr Met Glu Ala Tyr Ser Arg Met Ala Asn Arg Asp
        355                 360                 365             
Leu Leu Ser Ser Val Ser Arg Glu Phe Ser Gly Tyr Val Glu Ser Gly
    370                 375                 380                 
Leu Lys Thr Ile Leu Gln Cys Ala Leu Asn Arg Pro Ala Phe Phe Ala
385                 390                 395                 400 
Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp Ser Thr
                405                 410                 415     
Leu Val Arg Ile Val Val Thr Arg Ser Glu Ile Asp Leu Val Gln Ile
            420                 425                 430         
Lys Gln Met Phe Ala Gln Met Tyr Gln Lys Thr Leu Gly Thr Met Ile
        435                 440                 445             
Ala Gly Asp Thr Ser Gly Asp Tyr Arg Arg Leu Leu Leu Ala Ile Val
    450                 455                 460                 
Gly Gln
465     


<210> 378
<211> 181
<212> PRT
<213> Homo sapiens

<400> 378
Met Gly Asn Ile Phe Ala Asn Leu Phe Lys Gly Leu Phe Gly Lys Lys
 1               5                  10                  15      
Glu Met Arg Ile Leu Met Val Gly Leu Asp Ala Ala Gly Lys Thr Thr
            20                  25                  30          
Ile Leu Tyr Lys Leu Lys Leu Gly Glu Ile Val Thr Thr Ile Pro Thr
        35                  40                  45              
Ile Gly Phe Asn Val Glu Thr Val Glu Tyr Lys Asn Ile Ser Phe Thr
    50                  55                  60                  
Val Trp Asp Val Gly Gly Gln Asp Lys Ile Arg Pro Leu Trp Arg His
65                  70                  75                  80  
Tyr Phe Gln Asn Thr Gln Gly Leu Ile Phe Val Val Asp Ser Asn Asp
                85                  90                  95      
Arg Glu Arg Val Asn Glu Ala Arg Glu Glu Leu Met Arg Met Leu Ala
            100                 105                 110         
Glu Asp Glu Leu Arg Asp Ala Val Leu Leu Val Phe Ala Asn Lys Gln
        115                 120                 125             
Asp Leu Pro Asn Ala Met Asn Ala Ala Glu Ile Thr Asp Lys Leu Gly
    130                 135                 140                 
Leu His Ser Leu Arg His Arg Asn Trp Tyr Ile Gln Ala Thr Cys Ala
145                 150                 155                 160 
Thr Ser Gly Asp Gly Leu Tyr Glu Gly Leu Asp Trp Leu Ser Asn Gln
                165                 170                 175     
Leu Arg Asn Gln Lys
            180     


<210> 379
<211> 1013
<212> PRT
<213> Homo sapiens

<400> 379
Met Gly Asp Lys Lys Asp Asp Lys Asp Ser Pro Lys Lys Asn Lys Gly
 1               5                  10                  15      
Lys Glu Arg Arg Asp Leu Asp Asp Leu Lys Lys Glu Val Ala Met Thr
            20                  25                  30          
Glu His Lys Met Ser Val Glu Glu Val Cys Arg Lys Tyr Asn Thr Asp
        35                  40                  45              
Cys Val Gln Gly Leu Thr His Ser Lys Ala Gln Glu Ile Leu Ala Arg
    50                  55                  60                  
Asp Gly Pro Asn Ala Leu Thr Pro Pro Pro Thr Thr Pro Glu Trp Val
65                  70                  75                  80  
Lys Phe Cys Arg Gln Leu Phe Gly Gly Phe Ser Ile Leu Leu Trp Ile
                85                  90                  95      
Gly Ala Ile Leu Cys Phe Leu Ala Tyr Gly Ile Gln Ala Gly Thr Glu
            100                 105                 110         
Asp Asp Pro Ser Gly Asp Asn Leu Tyr Leu Gly Ile Val Leu Ala Ala
        115                 120                 125             
Val Val Ile Ile Thr Gly Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser
    130                 135                 140                 
Ser Lys Ile Met Glu Ser Phe Lys Asn Met Val Pro Gln Gln Ala Leu
145                 150                 155                 160 
Val Ile Arg Glu Gly Glu Lys Met Gln Val Asn Ala Glu Glu Val Val
                165                 170                 175     
Val Gly Asp Leu Val Glu Ile Lys Gly Gly Asp Arg Val Pro Ala Asp
            180                 185                 190         
Leu Arg Ile Ile Ser Ala His Gly Cys Lys Val Asp Asn Ser Ser Leu
        195                 200                 205             
Thr Gly Glu Ser Glu Pro Gln Thr Arg Ser Pro Asp Cys Thr His Asp
    210                 215                 220                 
Asn Pro Leu Glu Thr Arg Asn Ile Thr Phe Phe Ser Thr Asn Cys Val
225                 230                 235                 240 
Glu Gly Thr Ala Arg Gly Val Val Val Ala Thr Gly Asp Arg Thr Val
                245                 250                 255     
Met Gly Arg Ile Ala Thr Leu Ala Ser Gly Leu Glu Val Gly Lys Thr
            260                 265                 270         
Pro Ile Ala Ile Glu Ile Glu His Phe Ile Gln Leu Ile Thr Gly Val
        275                 280                 285             
Ala Val Phe Leu Gly Val Ser Phe Phe Ile Leu Ser Leu Ile Leu Gly
    290                 295                 300                 
Tyr Thr Trp Leu Glu Ala Val Ile Phe Leu Ile Gly Ile Ile Val Ala
305                 310                 315                 320 
Asn Val Pro Glu Gly Leu Leu Ala Thr Val Thr Val Cys Leu Thr Val
                325                 330                 335     
Thr Ala Lys Arg Met Ala Arg Lys Asn Cys Leu Val Lys Asn Leu Glu
            340                 345                 350         
Ala Val Glu Thr Leu Gly Ser Thr Ser Thr Ile Cys Ser Asp Lys Thr
        355                 360                 365             
Gly Thr Leu Thr Gln Asn Arg Met Thr Val Ala His Met Trp Phe Asp
    370                 375                 380                 
Asn Gln Ile His Glu Ala Asp Thr Thr Glu Asp Gln Ser Gly Thr Ser
385                 390                 395                 400 
Phe Asp Lys Ser Ser His Thr Trp Val Ala Leu Ser His Ile Ala Gly
                405                 410                 415     
Leu Cys Asn Arg Ala Val Phe Lys Gly Gly Gln Asp Asn Ile Pro Val
            420                 425                 430         
Leu Lys Arg Asp Val Ala Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys
        435                 440                 445             
Cys Ile Glu Leu Ser Ser Gly Ser Val Lys Leu Met Arg Glu Arg Asn
    450                 455                 460                 
Lys Lys Val Ala Glu Ile Pro Phe Asn Ser Thr Asn Lys Tyr Gln Leu
465                 470                 475                 480 
Ser Ile His Glu Thr Glu Asp Pro Asn Asp Asn Arg Tyr Leu Leu Val
                485                 490                 495     
Met Lys Gly Ala Pro Glu Arg Ile Leu Asp Arg Cys Ser Thr Ile Leu
            500                 505                 510         
Leu Gln Gly Lys Glu Gln Pro Leu Asp Glu Glu Met Lys Glu Ala Phe
        515                 520                 525             
Gln Asn Ala Tyr Leu Glu Leu Gly Gly Leu Gly Glu Arg Val Leu Gly
    530                 535                 540                 
Phe Cys His Tyr Tyr Leu Pro Glu Glu Gln Tyr Pro Gln Gly Phe Ala
545                 550                 555                 560 
Phe Asp Cys Asp Asp Val Asn Phe Thr Thr Asp Asn Leu Cys Phe Val
                565                 570                 575     
Pro Leu Met Ser Met Ile Gly Pro Pro Arg Ala Ala Val Pro Asp Ala
            580                 585                 590         
Val Gly Lys Cys Arg Ser Ala Gly Ile Lys Val Ile Met Val Thr Gly
        595                 600                 605             
Asp His Pro Ile Thr Ala Lys Ala Ile Ala Lys Gly Val Gly Ile Ile
    610                 615                 620                 
Ser Glu Gly Asn Glu Thr Val Glu Asp Ile Ala Ala Arg Leu Asn Ile
625                 630                 635                 640 
Pro Val Ser Gln Val Asn Pro Arg Asp Ala Lys Ala Cys Val Ile His
                645                 650                 655     
Gly Thr Asp Leu Lys Asp Phe Thr Ser Glu Gln Ile Asp Glu Ile Leu
            660                 665                 670         
Gln Asn His Thr Glu Ile Val Phe Ala Arg Thr Ser Pro Gln Gln Lys
        675                 680                 685             
Leu Ile Ile Val Glu Gly Cys Gln Arg Gln Gly Ala Ile Val Ala Val
    690                 695                 700                 
Thr Gly Asp Gly Val Asn Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile
705                 710                 715                 720 
Gly Val Ala Met Gly Ile Ala Gly Ser Asp Val Ser Lys Gln Ala Ala
                725                 730                 735     
Asp Met Ile Leu Leu Asp Asp Asn Phe Ala Ser Ile Val Thr Gly Val
            740                 745                 750         
Glu Glu Gly Arg Leu Ile Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr
        755                 760                 765             
Thr Leu Thr Ser Asn Ile Pro Glu Ile Thr Pro Phe Leu Leu Phe Ile
    770                 775                 780                 
Met Ala Asn Ile Pro Leu Pro Leu Gly Thr Ile Thr Ile Leu Cys Ile
785                 790                 795                 800 
Asp Leu Gly Thr Asp Met Val Pro Ala Ile Ser Leu Ala Tyr Glu Ala
                805                 810                 815     
Ala Glu Ser Asp Ile Met Lys Arg Gln Pro Arg Asn Pro Arg Thr Asp
            820                 825                 830         
Lys Leu Val Asn Glu Arg Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly
        835                 840                 845             
Met Ile Gln Ala Leu Gly Gly Phe Phe Ser Tyr Phe Val Ile Leu Ala
    850                 855                 860                 
Glu Asn Gly Phe Leu Pro Gly Asn Leu Val Gly Ile Arg Leu Asn Trp
865                 870                 875                 880 
Asp Asp Arg Thr Val Asn Asp Leu Glu Asp Ser Tyr Gly Gln Gln Trp
                885                 890                 895     
Thr Tyr Glu Gln Arg Lys Val Val Glu Phe Thr Cys His Thr Ala Phe
            900                 905                 910         
Phe Val Ser Ile Val Val Val Gln Trp Ala Asp Leu Ile Ile Cys Lys
        915                 920                 925             
Thr Arg Arg Asn Ser Val Phe Gln Gln Gly Met Lys Asn Lys Ile Leu
    930                 935                 940                 
Ile Phe Gly Leu Phe Glu Glu Thr Ala Leu Ala Ala Phe Leu Ser Tyr
945                 950                 955                 960 
Cys Pro Gly Met Asp Val Ala Leu Arg Met Tyr Pro Leu Lys Pro Ser
                965                 970                 975     
Trp Trp Phe Cys Ala Phe Pro Tyr Ser Phe Leu Ile Phe Val Tyr Asp
            980                 985                 990         
Glu Ile Arg Lys Leu Ile Leu Arg Arg Asn Pro Gly Gly Ser Val Glu
        995                 1000                1005            
Lys Glu Thr Tyr Tyr
    1010            


<210> 380
<211> 168
<212> PRT
<213> Homo sapiens

<400> 380
Met Leu Pro Ala Ala Leu Leu Arg Arg Pro Gly Leu Gly Arg Leu Val
 1               5                  10                  15      
Arg His Ala Arg Ala Tyr Ala Glu Ala Ala Ala Ala Pro Ala Ala Ala
            20                  25                  30          
Ser Gly Pro Asn Gln Met Ser Phe Thr Phe Ala Ser Pro Thr Gln Val
        35                  40                  45              
Phe Phe Asn Gly Ala Asn Val Arg Gln Val Asp Val Pro Thr Leu Thr
    50                  55                  60                  
Gly Ala Phe Gly Ile Leu Ala Ala His Val Pro Thr Leu Gln Val Leu
65                  70                  75                  80  
Arg Pro Gly Leu Val Val Val His Ala Glu Asp Gly Thr Thr Ser Lys
                85                  90                  95      
Tyr Phe Val Ser Ser Gly Ser Ile Ala Val Asn Ala Asp Ser Ser Val
            100                 105                 110         
Gln Leu Leu Ala Glu Glu Ala Val Thr Leu Asp Met Leu Asp Leu Gly
        115                 120                 125             
Ala Ala Lys Ala Asn Leu Glu Lys Ala Gln Ala Glu Leu Val Gly Thr
    130                 135                 140                 
Ala Asp Glu Ala Thr Arg Ala Glu Ile Gln Ile Arg Ile Glu Ala Asn
145                 150                 155                 160 
Glu Ala Leu Val Lys Ala Leu Glu
                165             


<210> 381
<211> 213
<212> PRT
<213> Homo sapiens

<400> 381
Met Ala Ala Pro Ala Val Ser Gly Leu Ser Arg Gln Val Arg Cys Phe
 1               5                  10                  15      
Ser Thr Ser Val Val Arg Pro Phe Ala Lys Leu Val Arg Pro Pro Val
            20                  25                  30          
Gln Val Tyr Gly Ile Glu Gly Arg Tyr Ala Thr Ala Leu Tyr Ser Ala
        35                  40                  45              
Ala Ser Lys Gln Asn Lys Leu Glu Gln Val Glu Lys Glu Leu Leu Arg
    50                  55                  60                  
Val Ala Gln Ile Leu Lys Glu Pro Lys Val Ala Ala Ser Val Leu Asn
65                  70                  75                  80  
Pro Tyr Val Lys Arg Ser Ile Lys Val Lys Ser Leu Asn Asp Ile Thr
                85                  90                  95      
Ala Lys Glu Arg Phe Ser Pro Leu Thr Thr Asn Leu Ile Asn Leu Leu
            100                 105                 110         
Ala Glu Asn Gly Arg Leu Ser Asn Thr Gln Gly Val Val Ser Ala Phe
        115                 120                 125             
Ser Thr Met Met Ser Val His Arg Gly Glu Val Pro Cys Thr Val Thr
    130                 135                 140                 
Ser Ala Ser Pro Leu Glu Glu Ala Thr Leu Ser Glu Leu Lys Thr Val
145                 150                 155                 160 
Leu Lys Ser Phe Leu Ser Gln Gly Gln Val Leu Lys Leu Glu Ala Lys
                165                 170                 175     
Thr Asp Pro Ser Ile Leu Gly Gly Met Ile Val Arg Ile Gly Glu Lys
            180                 185                 190         
Tyr Val Asp Met Ser Val Lys Thr Lys Ile Gln Lys Leu Gly Arg Ala
        195                 200                 205             
Met Arg Glu Ile Val
    210             


<210> 382
<211> 339
<212> PRT
<213> Homo sapiens

<400> 382
Met Ala Ala Ala Val Ala Ala Ala Pro Gly Ala Leu Gly Ser Leu His
 1               5                  10                  15      
Ala Gly Gly Ala Arg Leu Val Ala Ala Cys Ser Ala Trp Leu Cys Pro
            20                  25                  30          
Gly Leu Arg Leu Pro Gly Ser Leu Ala Gly Arg Arg Ala Gly Pro Ala
        35                  40                  45              
Ile Trp Ala Gln Gly Trp Val Pro Ala Ala Gly Gly Pro Ala Pro Lys
    50                  55                  60                  
Arg Gly Tyr Ser Ser Glu Met Lys Thr Glu Asp Glu Leu Arg Val Arg
65                  70                  75                  80  
His Leu Glu Glu Glu Asn Arg Gly Ile Val Val Leu Gly Ile Asn Arg
                85                  90                  95      
Ala Tyr Gly Lys Asn Ser Leu Ser Lys Asn Leu Ile Lys Met Leu Ser
            100                 105                 110         
Lys Ala Val Asp Ala Leu Lys Ser Asp Lys Lys Val Arg Thr Ile Ile
        115                 120                 125             
Ile Arg Ser Glu Val Pro Gly Ile Phe Cys Ala Gly Ala Asp Leu Lys
    130                 135                 140                 
Glu Arg Ala Lys Met Ser Ser Ser Glu Val Gly Pro Phe Val Ser Lys
145                 150                 155                 160 
Ile Arg Ala Val Ile Asn Asp Ile Ala Asn Leu Pro Val Pro Thr Ile
                165                 170                 175     
Ala Ala Ile Asp Gly Leu Ala Leu Gly Gly Gly Leu Glu Leu Ala Leu
            180                 185                 190         
Ala Cys Asp Ile Arg Val Ala Ala Ser Ser Ala Lys Met Gly Leu Val
        195                 200                 205             
Glu Thr Lys Leu Ala Ile Ile Pro Gly Gly Gly Gly Thr Gln Arg Leu
    210                 215                 220                 
Pro Arg Ala Ile Gly Met Ser Leu Ala Lys Glu Leu Ile Phe Ser Ala
225                 230                 235                 240 
Arg Val Leu Asp Gly Lys Glu Ala Lys Ala Val Gly Leu Ile Ser His
                245                 250                 255     
Val Leu Glu Gln Asn Gln Glu Gly Asp Ala Ala Tyr Arg Lys Ala Leu
            260                 265                 270         
Asp Leu Ala Arg Glu Phe Leu Pro Gln Gly Pro Val Ala Met Arg Val
        275                 280                 285             
Ala Lys Leu Ala Ile Asn Gln Gly Met Glu Val Asp Leu Val Thr Gly
    290                 295                 300                 
Leu Ala Ile Glu Glu Ala Cys Tyr Ala Gln Thr Ile Pro Thr Lys Asp
305                 310                 315                 320 
Arg Leu Glu Gly Leu Leu Ala Phe Lys Glu Lys Arg Pro Pro Arg Tyr
                325                 330                 335     
Lys Gly Glu
            


<210> 383
<211> 418
<212> PRT
<213> Homo sapiens

<400> 383
Met Arg Leu Ser Ala Gly Pro Asp Ala Gly Pro Ser Gly Asn Ser Ser
 1               5                  10                  15      
Pro Trp Trp Pro Leu Ala Thr Gly Ala Gly Asn Thr Ser Arg Glu Ala
            20                  25                  30          
Glu Ala Leu Gly Glu Gly Asn Gly Pro Pro Arg Asp Val Arg Asn Glu
        35                  40                  45              
Glu Leu Ala Lys Leu Glu Ile Ala Val Leu Ala Val Thr Phe Ala Val
    50                  55                  60                  
Ala Val Leu Gly Asn Ser Ser Val Leu Leu Ala Leu His Arg Thr Pro
65                  70                  75                  80  
Arg Lys Thr Ser Arg Met His Leu Phe Ile Arg His Leu Ser Leu Ala
                85                  90                  95      
Asp Leu Ala Val Ala Phe Phe Gln Val Leu Pro Gln Met Cys Trp Asp
            100                 105                 110         
Ile Thr Tyr Arg Phe Arg Gly Pro Asp Trp Leu Cys Arg Val Val Lys
        115                 120                 125             
His Leu Gln Val Phe Gly Met Phe Ala Ser Ala Tyr Met Leu Val Val
    130                 135                 140                 
Met Thr Ala Asp Arg Tyr Ile Ala Val Cys His Pro Leu Lys Thr Leu
145                 150                 155                 160 
Gln Gln Pro Ala Arg Arg Ser Arg Leu Met Ile Ala Ala Ala Trp Val
                165                 170                 175     
Leu Ser Phe Val Leu Ser Thr Pro Gln Tyr Phe Val Phe Ser Met Ile
            180                 185                 190         
Glu Val Asn Asn Val Thr Lys Ala Arg Asp Cys Trp Ala Thr Phe Ile
        195                 200                 205             
Gln Pro Trp Gly Ser Arg Ala Tyr Val Thr Trp Met Thr Gly Gly Ile
    210                 215                 220                 
Phe Val Ala Pro Val Val Ile Leu Gly Thr Cys Tyr Gly Phe Ile Cys
225                 230                 235                 240 
Tyr Asn Ile Trp Cys Asn Val Arg Gly Lys Thr Ala Ser Arg Gln Ser
                245                 250                 255     
Lys Gly Ala Glu Gln Ala Gly Val Ala Phe Gln Lys Gly Phe Leu Leu
            260                 265                 270         
Ala Pro Cys Val Ser Ser Val Lys Ser Ile Ser Arg Ala Lys Ile Arg
        275                 280                 285             
Thr Val Lys Met Thr Phe Val Ile Val Thr Ala Tyr Ile Val Cys Trp
    290                 295                 300                 
Ala Pro Phe Phe Ile Ile Gln Met Trp Ser Val Trp Asp Pro Met Ser
305                 310                 315                 320 
Val Trp Thr Glu Ser Glu Asn Pro Thr Ile Thr Ile Thr Ala Leu Leu
                325                 330                 335     
Gly Ser Leu Asn Ser Cys Cys Asn Pro Trp Ile Tyr Met Phe Phe Ser
            340                 345                 350         
Gly His Leu Leu Gln Asp Cys Val Gln Ser Phe Pro Cys Cys Gln Asn
        355                 360                 365             
Met Lys Glu Lys Phe Asn Lys Glu Asp Thr Asp Ser Met Ser Arg Arg
    370                 375                 380                 
Gln Thr Phe Tyr Ser Asn Asn Arg Ser Pro Thr Asn Ser Thr Gly Met
385                 390                 395                 400 
Trp Lys Asp Ser Pro Lys Ser Ser Lys Ser Ile Lys Phe Ile Pro Val
                405                 410                 415     
Ser Thr
        


<210> 384
<211> 233
<212> PRT
<213> Homo sapiens

<400> 384
Met Glu Pro Thr Ala Pro Ser Leu Thr Glu Glu Asp Leu Thr Glu Val
 1               5                  10                  15      
Lys Lys Asp Ala Leu Glu Asn Leu Arg Val Tyr Leu Cys Glu Lys Ile
            20                  25                  30          
Ile Ala Glu Arg His Phe Asp His Leu Arg Ala Lys Lys Ile Leu Ser
        35                  40                  45              
Arg Glu Asp Thr Glu Glu Ile Ser Cys Arg Thr Ser Ser Arg Lys Arg
    50                  55                  60                  
Ala Gly Lys Leu Leu Asp Tyr Leu Gln Glu Asn Pro Lys Gly Leu Asp
65                  70                  75                  80  
Thr Leu Val Glu Ser Ile Arg Arg Glu Lys Thr Gln Asn Phe Leu Ile
                85                  90                  95      
Gln Lys Ile Thr Asp Glu Val Leu Lys Leu Arg Asn Ile Lys Leu Glu
            100                 105                 110         
His Leu Lys Gly Leu Lys Cys Ser Ser Cys Glu Pro Phe Pro Asp Gly
        115                 120                 125             
Ala Thr Asn Asn Leu Ser Arg Ser Asn Ser Asp Glu Ser Asn Phe Ser
    130                 135                 140                 
Glu Lys Leu Arg Ala Ser Thr Val Met Tyr His Pro Glu Gly Glu Ser
145                 150                 155                 160 
Ser Thr Thr Pro Phe Phe Ser Thr Asn Ser Ser Leu Asn Leu Pro Val
                165                 170                 175     
Leu Glu Val Gly Arg Thr Glu Asn Thr Ile Phe Ser Ser Thr Thr Leu
            180                 185                 190         
Pro Arg Pro Gly Asp Pro Gly Ala Pro Pro Leu Pro Pro Asp Leu Gln
        195                 200                 205             
Leu Glu Glu Glu Gly Thr Cys Ala Asn Ser Ser Glu Met Phe Leu Pro
    210                 215                 220                 
Leu Arg Ser Arg Thr Val Ser Arg Gln
225                 230             


<210> 385
<211> 206
<212> PRT
<213> Homo sapiens

<400> 385
Met Ala Val Lys Lys Ile Ala Ile Phe Gly Ala Thr Gly Gln Thr Gly
 1               5                  10                  15      
Leu Thr Thr Leu Ala Gln Ala Val Gln Ala Gly Tyr Glu Val Thr Val
            20                  25                  30          
Leu Val Arg Asp Ser Ser Arg Leu Pro Ser Glu Gly Pro Arg Pro Ala
        35                  40                  45              
His Val Val Val Gly Asp Val Leu Gln Ala Ala Asp Val Asp Lys Thr
    50                  55                  60                  
Val Ala Gly Gln Asp Ala Val Ile Val Leu Leu Gly Thr Arg Asn Asp
65                  70                  75                  80  
Leu Ser Pro Thr Thr Val Met Ser Glu Gly Ala Arg Asn Ile Val Ala
                85                  90                  95      
Ala Met Lys Ala His Gly Val Asp Lys Val Val Ala Cys Thr Ser Ala
            100                 105                 110         
Phe Leu Leu Trp Asp Pro Thr Lys Val Pro Pro Arg Leu Gln Ala Val
        115                 120                 125             
Thr Asp Asp His Ile Arg Met His Lys Val Leu Arg Glu Ser Gly Leu
    130                 135                 140                 
Lys Tyr Val Ala Val Met Pro Pro His Ile Gly Asp Gln Pro Leu Thr
145                 150                 155                 160 
Gly Ala Tyr Thr Val Thr Leu Asp Gly Arg Gly Pro Ser Arg Val Ile
                165                 170                 175     
Ser Lys His Asp Leu Gly His Phe Met Leu Arg Cys Leu Thr Thr Asp
            180                 185                 190         
Glu Tyr Asp Gly His Ser Thr Tyr Pro Ser His Gln Tyr Gln
        195                 200                 205     


<210> 386
<211> 1321
<212> PRT
<213> Homo sapiens

<400> 386
Met Ser Asp Ser Val Ile Leu Arg Ser Ile Lys Lys Phe Gly Glu Glu
 1               5                  10                  15      
Asn Asp Gly Phe Glu Ser Asp Lys Ser Tyr Asn Asn Asp Lys Lys Ser
            20                  25                  30          
Arg Leu Gln Asp Glu Lys Lys Gly Asp Gly Val Arg Val Gly Phe Phe
        35                  40                  45              
Gln Leu Phe Arg Phe Ser Ser Ser Thr Asp Ile Trp Leu Met Phe Val
    50                  55                  60                  
Gly Ser Leu Cys Ala Phe Leu His Gly Ile Ala Gln Pro Gly Val Leu
65                  70                  75                  80  
Leu Ile Phe Gly Thr Met Thr Asp Val Phe Ile Asp Tyr Asp Val Glu
                85                  90                  95      
Leu Gln Glu Leu Gln Ile Pro Gly Lys Ala Cys Val Asn Asn Thr Ile
            100                 105                 110         
Val Trp Thr Asn Ser Ser Leu Asn Gln Asn Met Thr Asn Gly Thr Arg
        115                 120                 125             
Cys Gly Leu Leu Asn Ile Glu Ser Glu Met Ile Lys Phe Ala Ser Tyr
    130                 135                 140                 
Tyr Ala Gly Ile Ala Val Ala Val Leu Ile Thr Gly Tyr Ile Gln Ile
145                 150                 155                 160 
Cys Phe Trp Val Ile Ala Ala Ala Arg Gln Ile Gln Lys Met Arg Lys
                165                 170                 175     
Phe Tyr Phe Arg Arg Ile Met Arg Met Glu Ile Gly Trp Phe Asp Cys
            180                 185                 190         
Asn Ser Val Gly Glu Leu Asn Thr Arg Phe Ser Asp Asp Ile Asn Lys
        195                 200                 205             
Ile Asn Asp Ala Ile Ala Asp Gln Met Ala Leu Phe Ile Gln Arg Met
    210                 215                 220                 
Thr Ser Thr Ile Cys Gly Phe Leu Leu Gly Phe Phe Arg Gly Trp Lys
225                 230                 235                 240 
Leu Thr Leu Val Ile Ile Ser Val Ser Pro Leu Ile Gly Ile Gly Ala
                245                 250                 255     
Ala Thr Ile Gly Leu Ser Val Ser Lys Phe Thr Asp Tyr Glu Leu Lys
            260                 265                 270         
Ala Tyr Ala Lys Ala Gly Val Val Ala Asp Glu Val Ile Ser Ser Met
        275                 280                 285             
Arg Thr Val Ala Ala Phe Gly Gly Glu Lys Arg Glu Val Glu Arg Tyr
    290                 295                 300                 
Glu Lys Asn Leu Val Phe Ala Gln Arg Trp Gly Ile Arg Lys Gly Ile
305                 310                 315                 320 
Val Met Gly Phe Phe Thr Gly Phe Val Trp Cys Leu Ile Phe Leu Cys
                325                 330                 335     
Tyr Ala Val Ala Phe Trp Tyr Gly Ser Thr Leu Val Leu Asp Glu Gly
            340                 345                 350         
Glu Tyr Thr Pro Gly Thr Leu Val Gln Ile Phe Leu Ser Val Ile Val
        355                 360                 365             
Gly Ala Leu Asn Leu Gly Asn Ala Ser Pro Cys Leu Glu Ala Phe Ala
    370                 375                 380                 
Thr Gly Arg Ala Ala Ala Thr Ser Ile Phe Glu Thr Ile Asp Arg Lys
385                 390                 395                 400 
Pro Ile Ile Asp Cys Met Ser Glu Asp Gly Tyr Lys Leu Asp Arg Ile
                405                 410                 415     
Lys Gly Glu Ile Glu Phe His Asn Val Thr Phe His Tyr Pro Ser Arg
            420                 425                 430         
Pro Glu Val Lys Ile Leu Asn Asp Leu Asn Met Val Ile Lys Pro Gly
        435                 440                 445             
Glu Met Thr Ala Leu Val Gly Pro Ser Gly Ala Gly Lys Ser Thr Ala
    450                 455                 460                 
Leu Gln Leu Ile Gln Arg Phe Tyr Asp Pro Cys Glu Gly Met Val Thr
465                 470                 475                 480 
Val Asp Gly His Asp Ile Arg Ser Leu Asn Ile Gln Trp Leu Arg Asp
                485                 490                 495     
Gln Ile Gly Ile Val Glu Gln Glu Pro Val Leu Phe Ser Thr Thr Ile
            500                 505                 510         
Ala Glu Asn Ile Arg Tyr Gly Arg Glu Asp Ala Thr Met Glu Asp Ile
        515                 520                 525             
Val Gln Ala Ala Lys Glu Ala Asn Ala Tyr Asn Phe Ile Met Asp Leu
    530                 535                 540                 
Pro Gln Gln Phe Asp Thr Leu Val Gly Glu Gly Gly Gly Gln Met Ser
545                 550                 555                 560 
Gly Gly Gln Lys Gln Arg Val Ala Ile Ala Arg Ala Leu Ile Arg Asn
                565                 570                 575     
Pro Lys Ile Leu Leu Leu Asp Met Ala Thr Ser Ala Leu Asp Asn Glu
            580                 585                 590         
Ser Glu Ala Met Val Gln Glu Val Leu Ser Lys Ile Gln His Gly His
        595                 600                 605             
Thr Ile Ile Ser Val Ala His Arg Leu Ser Thr Val Arg Ala Ala Asp
    610                 615                 620                 
Thr Ile Ile Gly Phe Glu His Gly Thr Ala Val Glu Arg Gly Thr His
625                 630                 635                 640 
Glu Glu Leu Leu Glu Arg Lys Gly Val Tyr Phe Thr Leu Val Thr Leu
                645                 650                 655     
Gln Ser Gln Gly Asn Gln Ala Leu Asn Glu Glu Asp Ile Lys Asp Ala
            660                 665                 670         
Thr Glu Asp Asp Met Leu Ala Arg Thr Phe Ser Arg Gly Ser Tyr Gln
        675                 680                 685             
Asp Ser Leu Arg Ala Ser Ile Arg Gln Arg Ser Lys Ser Gln Leu Ser
    690                 695                 700                 
Tyr Leu Val His Glu Pro Pro Leu Ala Val Val Asp His Lys Ser Thr
705                 710                 715                 720 
Tyr Glu Glu Asp Arg Lys Asp Lys Asp Ile Pro Val Gln Glu Glu Val
                725                 730                 735     
Glu Pro Ala Pro Val Arg Arg Ile Leu Lys Phe Ser Ala Pro Glu Trp
            740                 745                 750         
Pro Tyr Met Leu Val Gly Ser Val Gly Ala Ala Val Asn Gly Thr Val
        755                 760                 765             
Thr Pro Leu Tyr Ala Phe Leu Phe Ser Gln Ile Leu Gly Thr Phe Ser
    770                 775                 780                 
Ile Pro Asp Lys Glu Glu Gln Arg Ser Gln Ile Asn Gly Val Cys Leu
785                 790                 795                 800 
Leu Phe Val Ala Met Gly Cys Val Ser Leu Phe Thr Gln Phe Leu Gln
                805                 810                 815     
Gly Tyr Ala Phe Ala Lys Ser Gly Glu Leu Leu Thr Lys Arg Leu Arg
            820                 825                 830         
Lys Phe Gly Phe Arg Ala Met Leu Gly Gln Asp Ile Ala Trp Phe Asp
        835                 840                 845             
Asp Leu Arg Asn Ser Pro Gly Ala Leu Thr Thr Arg Leu Ala Thr Asp
    850                 855                 860                 
Ala Ser Gln Val Gln Gly Ala Ala Gly Ser Gln Ile Gly Met Ile Val
865                 870                 875                 880 
Asn Ser Phe Thr Asn Val Thr Val Ala Met Ile Ile Ala Phe Ser Phe
                885                 890                 895     
Ser Trp Lys Leu Ser Leu Val Ile Leu Cys Phe Phe Pro Phe Leu Ala
            900                 905                 910         
Leu Ser Gly Ala Thr Gln Thr Arg Met Leu Thr Gly Phe Ala Ser Arg
        915                 920                 925             
Asp Lys Gln Ala Leu Glu Met Val Gly Gln Ile Thr Asn Glu Ala Leu
    930                 935                 940                 
Ser Asn Ile Arg Thr Val Ala Gly Ile Gly Lys Glu Arg Arg Phe Ile
945                 950                 955                 960 
Glu Ala Leu Glu Thr Glu Leu Glu Lys Pro Phe Lys Thr Ala Ile Gln
                965                 970                 975     
Lys Ala Asn Ile Tyr Gly Phe Cys Phe Ala Phe Ala Gln Cys Ile Met
            980                 985                 990         
Phe Ile Ala Asn Ser Ala Ser Tyr Arg Tyr Gly Gly Tyr Leu Ile Ser
        995                 1000                1005            
Asn Glu Gly Leu His Phe Ser Tyr Val Phe Arg Val Ile Ser Ala Val
    1010                1015                1020                
Val Leu Ser Ala Thr Ala Leu Gly Arg Ala Phe Ser Tyr Thr Pro Ser
1025                1030                1035                1040
Tyr Ala Lys Ala Lys Ile Ser Ala Ala Arg Phe Phe Gln Leu Leu Asp
                1045                1050                1055    
Arg Gln Pro Pro Ile Ser Val Tyr Asn Thr Ala Gly Glu Lys Trp Asp
            1060                1065                1070        
Asn Phe Gln Gly Lys Ile Asp Phe Val Asp Cys Lys Phe Thr Tyr Pro
        1075                1080                1085            
Ser Arg Pro Asp Ser Gln Val Leu Asn Gly Leu Ser Val Ser Ile Ser
    1090                1095                1100                
Pro Gly Gln Thr Leu Ala Phe Val Gly Ser Ser Gly Cys Gly Lys Ser
1105                1110                1115                1120
Thr Ser Ile Gln Leu Leu Glu Arg Phe Tyr Asp Pro Asp Gln Gly Lys
                1125                1130                1135    
Val Met Ile Asp Gly His Asp Ser Lys Lys Val Asn Val Gln Phe Leu
            1140                1145                1150        
Arg Ser Asn Ile Gly Ile Val Ser Gln Glu Pro Val Leu Phe Ala Cys
        1155                1160                1165            
Ser Ile Met Asp Asn Ile Lys Tyr Gly Asp Asn Thr Lys Glu Ile Pro
    1170                1175                1180                
Met Glu Arg Val Ile Ala Ala Ala Lys Gln Ala Gln Leu His Asp Phe
1185                1190                1195                1200
Val Met Ser Leu Pro Glu Lys Tyr Glu Thr Asn Val Gly Ser Gln Gly
                1205                1210                1215    
Ser Gln Leu Ser Arg Gly Glu Lys Gln Arg Ile Ala Ile Ala Arg Ala
            1220                1225                1230        
Ile Val Arg Asp Pro Lys Ile Leu Leu Leu Asp Glu Ala Thr Ser Ala
        1235                1240                1245            
Leu Asp Thr Glu Ser Glu Lys Thr Val Gln Val Ala Leu Asp Lys Ala
    1250                1255                1260                
Arg Glu Gly Arg Thr Cys Ile Val Ile Ala His Arg Leu Ser Thr Ile
1265                1270                1275                1280
Gln Asn Ala Asp Ile Ile Ala Val Met Ala Gln Gly Val Val Ile Glu
                1285                1290                1295    
Lys Gly Thr His Glu Glu Leu Met Ala Gln Lys Gly Ala Tyr Tyr Lys
            1300                1305                1310        
Leu Val Thr Thr Gly Ser Pro Ile Ser
        1315                1320    


<210> 387
<211> 269
<212> PRT
<213> Homo sapiens

<400> 387
Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Thr
 1               5                  10                  15      
His Gly Ala Ser Gly Ala Ala Gly Thr Val Phe Thr Thr Val Glu Asp
            20                  25                  30          
Leu Gly Ser Lys Ile Leu Leu Thr Cys Ser Leu Asn Asp Ser Ala Thr
        35                  40                  45              
Glu Val Thr Gly His Arg Trp Leu Lys Gly Gly Val Val Leu Lys Glu
    50                  55                  60                  
Asp Ala Leu Pro Gly Gln Lys Thr Glu Phe Lys Val Asp Ser Asp Asp
65                  70                  75                  80  
Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu Pro Met Gly Thr
                85                  90                  95      
Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys Ala Val Lys Ser
            100                 105                 110         
Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu Val Cys Lys Ser
        115                 120                 125             
Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr Lys Ile Thr Asp
    130                 135                 140                 
Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser Arg Phe Phe Val
145                 150                 155                 160 
Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu Asn Leu Asn Met
                165                 170                 175     
Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr Ser Ser Lys Gly
            180                 185                 190         
Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser His Leu Ala Ala
        195                 200                 205             
Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu Val Leu Val Thr
    210                 215                 220                 
Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu Asp Val Leu Asp
225                 230                 235                 240 
Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser Gly Gln His Gln
                245                 250                 255     
Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser Ser
            260                 265                 


<210> 388
<211> 350
<212> PRT
<213> Homo sapiens

<400> 388
Met Asn Ser Phe Asn Tyr Thr Thr Pro Asp Tyr Gly His Tyr Asp Asp
 1               5                  10                  15      
Lys Asp Thr Leu Asp Leu Asn Thr Pro Val Asp Lys Thr Ser Asn Thr
            20                  25                  30          
Leu Arg Val Pro Asp Ile Leu Ala Leu Val Ile Phe Ala Val Val Phe
        35                  40                  45              
Leu Val Gly Val Leu Gly Asn Ala Leu Val Val Trp Val Thr Ala Phe
    50                  55                  60                  
Glu Ala Lys Arg Thr Ile Asn Ala Ile Trp Phe Leu Asn Leu Ala Val
65                  70                  75                  80  
Ala Asp Phe Leu Ser Cys Leu Ala Leu Pro Ile Leu Phe Thr Ser Ile
                85                  90                  95      
Val Gln His His His Trp Pro Phe Gly Gly Ala Ala Cys Ser Ile Leu
            100                 105                 110         
Pro Ser Leu Ile Leu Leu Asn Met Tyr Ala Ser Ile Leu Leu Leu Ala
        115                 120                 125             
Thr Ile Ser Ala Asp Arg Phe Leu Leu Val Phe Lys Pro Ile Trp Cys
    130                 135                 140                 
Gln Asn Phe Arg Gly Ala Gly Leu Ala Trp Ile Ala Cys Ala Val Ala
145                 150                 155                 160 
Trp Gly Leu Ala Leu Leu Leu Thr Ile Pro Ser Phe Leu Tyr Arg Val
                165                 170                 175     
Val Arg Glu Glu Tyr Phe Pro Pro Lys Val Leu Cys Gly Val Asp Tyr
            180                 185                 190         
Ser His Asp Lys Arg Arg Glu Arg Ala Val Ala Ile Val Arg Leu Val
        195                 200                 205             
Leu Gly Phe Leu Trp Pro Leu Leu Thr Leu Thr Ile Cys Tyr Thr Phe
    210                 215                 220                 
Ile Leu Leu Arg Thr Trp Ser Arg Arg Ala Thr Arg Ser Thr Lys Thr
225                 230                 235                 240 
Leu Lys Val Val Val Ala Val Val Ala Ser Phe Phe Ile Phe Trp Leu
                245                 250                 255     
Pro Tyr Gln Val Thr Gly Ile Met Met Ser Phe Leu Glu Pro Ser Ser
            260                 265                 270         
Pro Thr Phe Leu Leu Leu Asn Lys Leu Asp Ser Leu Cys Val Ser Phe
        275                 280                 285             
Ala Tyr Ile Asn Cys Cys Ile Asn Pro Ile Ile Tyr Val Val Ala Gly
    290                 295                 300                 
Gln Gly Phe Gln Gly Arg Leu Arg Lys Ser Leu Pro Ser Leu Leu Arg
305                 310                 315                 320 
Asn Val Leu Thr Glu Glu Ser Val Val Arg Glu Ser Lys Ser Phe Thr
                325                 330                 335     
Arg Ser Thr Val Asp Thr Met Ala Gln Lys Thr Gln Ala Val
            340                 345                 350 


<210> 389
<211> 261
<212> PRT
<213> Homo sapiens

<400> 389
Met Ala Ser Pro Asp Trp Gly Tyr Asp Asp Lys Asn Gly Pro Glu Gln
 1               5                  10                  15      
Trp Ser Lys Leu Tyr Pro Ile Ala Asn Gly Asn Asn Gln Ser Pro Val
            20                  25                  30          
Asp Ile Lys Thr Ser Glu Thr Lys His Asp Thr Ser Leu Lys Pro Ile
        35                  40                  45              
Ser Val Ser Tyr Asn Pro Ala Thr Ala Lys Glu Ile Ile Asn Val Gly
    50                  55                  60                  
His Ser Phe His Val Asn Phe Glu Asp Asn Asp Asn Arg Ser Val Leu
65                  70                  75                  80  
Lys Gly Gly Pro Phe Ser Asp Ser Tyr Arg Leu Phe Gln Phe His Phe
                85                  90                  95      
His Trp Gly Ser Thr Asn Glu His Gly Ser Glu His Thr Val Asp Gly
            100                 105                 110         
Val Lys Tyr Ser Ala Glu Leu His Val Ala His Trp Asn Ser Ala Lys
        115                 120                 125             
Tyr Ser Ser Leu Ala Glu Ala Ala Ser Lys Ala Asp Gly Leu Ala Val
    130                 135                 140                 
Ile Gly Val Leu Met Lys Val Gly Glu Ala Asn Pro Lys Leu Gln Lys
145                 150                 155                 160 
Val Leu Asp Ala Leu Gln Ala Ile Lys Thr Lys Gly Lys Arg Ala Pro
                165                 170                 175     
Phe Thr Asn Phe Asp Pro Ser Thr Leu Leu Pro Ser Ser Leu Asp Phe
            180                 185                 190         
Trp Thr Tyr Pro Gly Ser Leu Thr His Pro Pro Leu Tyr Glu Ser Val
        195                 200                 205             
Thr Trp Ile Ile Cys Lys Glu Ser Ile Ser Val Ser Ser Glu Gln Leu
    210                 215                 220                 
Ala Gln Phe Arg Ser Leu Leu Ser Asn Val Glu Gly Asp Asn Ala Val
225                 230                 235                 240 
Pro Met Gln His Asn Asn Arg Pro Thr Gln Pro Leu Lys Gly Arg Thr
                245                 250                 255     
Val Arg Ala Ser Phe
            260     


<210> 390
<211> 700
<212> PRT
<213> Homo sapiens

<400> 390
Met Ala Gly Ile Ala Ala Lys Leu Ala Lys Asp Arg Glu Ala Ala Glu
 1               5                  10                  15      
Gly Leu Gly Ser His Glu Arg Ala Ile Lys Tyr Leu Asn Gln Asp Tyr
            20                  25                  30          
Glu Ala Leu Arg Asn Glu Cys Leu Glu Ala Gly Thr Leu Phe Gln Asp
        35                  40                  45              
Pro Ser Phe Pro Ala Ile Pro Ser Ala Leu Gly Phe Lys Glu Leu Gly
    50                  55                  60                  
Pro Tyr Ser Ser Lys Thr Arg Gly Met Arg Trp Lys Arg Pro Thr Glu
65                  70                  75                  80  
Ile Cys Ala Asp Pro Gln Phe Ile Ile Gly Gly Ala Thr Arg Thr Asp
                85                  90                  95      
Ile Cys Gln Gly Ala Leu Gly Asp Cys Trp Leu Leu Ala Ala Ile Ala
            100                 105                 110         
Ser Leu Thr Leu Asn Glu Glu Ile Leu Ala Arg Val Val Pro Leu Asn
        115                 120                 125             
Gln Ser Phe Gln Glu Asn Tyr Ala Gly Ile Phe His Phe Gln Phe Trp
    130                 135                 140                 
Gln Tyr Gly Glu Trp Val Glu Val Val Val Asp Asp Arg Leu Pro Thr
145                 150                 155                 160 
Lys Asp Gly Glu Leu Leu Phe Val His Ser Ala Glu Gly Ser Glu Phe
                165                 170                 175     
Trp Ser Ala Leu Leu Glu Lys Ala Tyr Ala Lys Ile Asn Gly Cys Tyr
            180                 185                 190         
Glu Ala Leu Ser Gly Gly Ala Thr Thr Glu Gly Phe Glu Asp Phe Thr
        195                 200                 205             
Gly Gly Ile Ala Glu Trp Tyr Glu Leu Lys Lys Pro Pro Pro Asn Leu
    210                 215                 220                 
Phe Lys Ile Ile Gln Lys Ala Leu Gln Lys Gly Ser Leu Leu Gly Cys
225                 230                 235                 240 
Ser Ile Asp Ile Thr Ser Ala Ala Asp Ser Glu Ala Ile Thr Phe Gln
                245                 250                 255     
Lys Leu Val Lys Gly His Ala Tyr Ser Val Thr Gly Ala Glu Glu Val
            260                 265                 270         
Glu Ser Asn Gly Ser Leu Gln Lys Leu Ile Arg Ile Arg Asn Pro Trp
        275                 280                 285             
Gly Glu Val Glu Trp Thr Gly Arg Trp Asn Asp Asn Cys Pro Ser Trp
    290                 295                 300                 
Asn Thr Ile Asp Pro Glu Glu Arg Glu Arg Leu Thr Arg Arg His Glu
305                 310                 315                 320 
Asp Gly Glu Phe Trp Met Ser Phe Ser Asp Phe Leu Arg His Tyr Ser
                325                 330                 335     
Arg Leu Glu Ile Cys Asn Leu Thr Pro Asp Thr Leu Thr Ser Asp Thr
            340                 345                 350         
Tyr Lys Lys Trp Lys Leu Thr Lys Met Asp Gly Asn Trp Arg Arg Gly
        355                 360                 365             
Ser Thr Ala Gly Gly Cys Arg Asn Tyr Pro Asn Thr Phe Trp Met Asn
    370                 375                 380                 
Pro Gln Tyr Leu Ile Lys Leu Glu Glu Glu Asp Glu Asp Glu Glu Asp
385                 390                 395                 400 
Gly Glu Ser Gly Cys Thr Phe Leu Val Gly Leu Ile Gln Lys His Arg
                405                 410                 415     
Arg Arg Gln Arg Lys Met Gly Glu Asp Met His Thr Ile Gly Phe Gly
            420                 425                 430         
Ile Tyr Glu Val Pro Glu Glu Leu Ser Gly Gln Thr Asn Ile His Leu
        435                 440                 445             
Ser Lys Asn Phe Phe Leu Thr Asn Arg Ala Arg Glu Arg Ser Asp Thr
    450                 455                 460                 
Phe Ile Asn Leu Arg Glu Val Leu Asn Arg Phe Lys Leu Pro Pro Gly
465                 470                 475                 480 
Glu Tyr Ile Leu Val Pro Ser Thr Phe Glu Pro Asn Lys Asp Gly Asp
                485                 490                 495     
Phe Cys Ile Arg Val Phe Ser Glu Lys Lys Ala Asp Tyr Gln Ala Val
            500                 505                 510         
Asp Asp Glu Ile Glu Ala Asn Leu Glu Glu Phe Asp Ile Ser Glu Asp
        515                 520                 525             
Asp Ile Asp Asp Gly Val Arg Arg Leu Phe Ala Gln Leu Ala Gly Glu
    530                 535                 540                 
Asp Ala Glu Ile Ser Ala Phe Glu Leu Gln Thr Ile Leu Arg Arg Val
545                 550                 555                 560 
Leu Ala Lys Arg Gln Asp Ile Lys Ser Asp Gly Phe Ser Ile Glu Thr
                565                 570                 575     
Cys Lys Ile Met Val Asp Met Leu Asp Ser Asp Gly Ser Gly Lys Leu
            580                 585                 590         
Gly Leu Lys Glu Phe Tyr Ile Leu Trp Thr Lys Ile Gln Lys Tyr Gln
        595                 600                 605             
Lys Ile Tyr Arg Glu Ile Asp Val Asp Arg Ser Gly Thr Met Asn Ser
    610                 615                 620                 
Tyr Glu Met Arg Lys Ala Leu Glu Glu Ala Gly Phe Lys Met Pro Cys
625                 630                 635                 640 
Gln Leu His Gln Val Ile Val Ala Arg Phe Ala Asp Asp Gln Leu Ile
                645                 650                 655     
Ile Asp Phe Asp Asn Phe Val Arg Cys Leu Val Arg Leu Glu Thr Leu
            660                 665                 670         
Phe Lys Ile Phe Lys Gln Leu Asp Pro Glu Asn Thr Gly Thr Ile Glu
        675                 680                 685             
Leu Asp Leu Ile Ser Trp Leu Cys Phe Ser Val Leu
    690                 695                 700 


<210> 391
<211> 277
<212> PRT
<213> Homo sapiens

<400> 391
Met Ser Ser Cys Ser Arg Val Ala Leu Val Thr Gly Ala Asn Arg Gly
 1               5                  10                  15      
Ile Gly Leu Ala Ile Ala Arg Glu Leu Cys Arg Gln Phe Ser Gly Asp
            20                  25                  30          
Val Val Leu Thr Ala Arg Asp Val Ala Arg Gly Gln Ala Ala Val Gln
        35                  40                  45              
Gln Leu Gln Ala Glu Gly Leu Ser Pro Arg Phe His Gln Leu Asp Ile
    50                  55                  60                  
Asp Asp Leu Gln Ser Ile Arg Ala Leu Arg Asp Phe Leu Arg Lys Glu
65                  70                  75                  80  
Tyr Gly Gly Leu Asn Val Leu Val Asn Asn Ala Ala Val Ala Phe Lys
                85                  90                  95      
Ser Asp Asp Pro Met Pro Phe Asp Ile Lys Ala Glu Met Thr Leu Lys
            100                 105                 110         
Thr Asn Phe Phe Ala Thr Arg Asn Met Cys Asn Glu Leu Leu Pro Ile
        115                 120                 125             
Met Lys Pro His Gly Arg Val Val Asn Ile Ser Ser Leu Gln Cys Leu
    130                 135                 140                 
Arg Ala Phe Glu Asn Cys Ser Glu Asp Leu Gln Glu Arg Phe His Ser
145                 150                 155                 160 
Glu Thr Leu Thr Glu Gly Asp Leu Val Asp Leu Met Lys Lys Phe Val
                165                 170                 175     
Glu Asp Thr Lys Asn Glu Val His Glu Arg Glu Gly Trp Pro Asn Ser
            180                 185                 190         
Pro Tyr Gly Val Ser Lys Leu Gly Val Thr Val Leu Ser Arg Ile Leu
        195                 200                 205             
Ala Arg Arg Leu Asp Glu Lys Arg Lys Ala Asp Arg Ile Leu Val Asn
    210                 215                 220                 
Ala Cys Cys Pro Gly Pro Val Lys Thr Asp Met Asp Gly Lys Asp Ser
225                 230                 235                 240 
Ile Arg Thr Val Glu Glu Gly Ala Glu Thr Pro Val Tyr Leu Ala Leu
                245                 250                 255     
Leu Pro Pro Asp Ala Thr Glu Pro Gln Gly Gln Leu Val His Asp Lys
            260                 265                 270         
Val Val Gln Asn Trp
        275         


<210> 392
<211> 558
<212> PRT
<213> Homo sapiens

<400> 392
Met Glu Leu Pro Ala Val Gly Glu His Val Phe Ala Val Glu Ser Ile
 1               5                  10                  15      
Glu Lys Lys Arg Ile Arg Lys Gly Arg Val Glu Tyr Leu Val Lys Trp
            20                  25                  30          
Arg Gly Trp Ser Pro Lys Tyr Asn Thr Trp Glu Pro Glu Glu Asn Ile
        35                  40                  45              
Leu Asp Pro Arg Leu Leu Ile Ala Phe Gln Asn Arg Glu Arg Gln Glu
    50                  55                  60                  
Gln Leu Met Gly Tyr Arg Lys Arg Gly Pro Lys Pro Lys Pro Leu Val
65                  70                  75                  80  
Val Gln Val Pro Thr Phe Ala Arg Arg Ser Asn Val Leu Thr Gly Leu
                85                  90                  95      
Gln Asp Ser Ser Thr Asp Asn Arg Ala Lys Leu Asp Leu Gly Ala Gln
            100                 105                 110         
Gly Lys Gly Gln Gly His Gln Tyr Glu Leu Asn Ser Lys Lys His His
        115                 120                 125             
Gln Tyr Gln Pro His Ser Lys Glu Gly Lys Pro Arg Pro Pro Gly Lys
    130                 135                 140                 
Ser Gly Lys Tyr Tyr Tyr Gln Leu Asn Ser Lys Lys His His Pro Tyr
145                 150                 155                 160 
Gln Pro Asp Pro Lys Met Tyr Asp Leu Gln Tyr Gln Gly Gly His Lys
                165                 170                 175     
Glu Ala Pro Ser Pro Thr Cys Pro Asp Leu Gly Ala Lys Ser His Pro
            180                 185                 190         
Pro Asp Lys Trp Ala Gln Gly Ala Gly Ala Lys Gly Tyr Leu Gly Ala
        195                 200                 205             
Val Lys Pro Leu Ala Gly Ala Ala Gly Ala Pro Gly Lys Gly Ser Glu
    210                 215                 220                 
Lys Gly Pro Pro Asn Gly Met Met Pro Ala Pro Lys Glu Ala Val Thr
225                 230                 235                 240 
Gly Asn Gly Ile Gly Gly Lys Met Lys Ile Val Lys Asn Lys Asn Lys
                245                 250                 255     
Asn Gly Arg Ile Val Ile Val Met Ser Lys Tyr Met Glu Asn Gly Met
            260                 265                 270         
Gln Ala Val Lys Ile Lys Ser Gly Glu Val Ala Glu Gly Glu Ala Arg
        275                 280                 285             
Ser Pro Ser His Lys Lys Arg Ala Ala Asp Glu Arg His Pro Pro Ala
    290                 295                 300                 
Asp Arg Thr Phe Lys Lys Ala Ala Gly Ala Glu Glu Lys Lys Val Glu
305                 310                 315                 320 
Ala Pro Pro Lys Arg Arg Glu Glu Glu Val Ser Gly Val Ser Asp Pro
                325                 330                 335     
Gln Pro Gln Asp Ala Gly Ser Arg Lys Leu Ser Pro Thr Lys Glu Ala
            340                 345                 350         
Phe Gly Glu Gln Pro Leu Gln Leu Thr Thr Lys Pro Asp Leu Leu Ala
        355                 360                 365             
Trp Asp Pro Ala Arg Asn Thr His Pro Pro Ser His His Pro His Pro
    370                 375                 380                 
His Pro His His His His His His His His His His His His Ala Val
385                 390                 395                 400 
Gly Leu Asn Leu Ser His Val Arg Lys Arg Cys Leu Ser Glu Thr His
                405                 410                 415     
Gly Glu Arg Glu Pro Cys Lys Lys Arg Leu Thr Ala Arg Ser Ile Ser
            420                 425                 430         
Thr Pro Thr Cys Leu Gly Gly Ser Pro Ala Ala Glu Arg Pro Ala Asp
        435                 440                 445             
Leu Pro Pro Ala Ala Ala Leu Arg Gln Pro Glu Val Ile Leu Leu Asp
    450                 455                 460                 
Ser Asp Leu Asp Glu Pro Ile Asp Leu Arg Ser Val Lys Ser Arg Ser
465                 470                 475                 480 
Glu Ala Gly Glu Pro Pro Ser Ser Leu Gln Val Lys Pro Glu Thr Pro
                485                 490                 495     
Ala Ser Ala Ala Val Ala Val Ala Ala Ala Ala Ala Pro Thr Thr Thr
            500                 505                 510         
Ala Glu Lys Pro Pro Ala Glu Ala Gln Asp Glu Pro Ala Glu Ser Leu
        515                 520                 525             
Ser Glu Phe Lys Pro Phe Phe Gly Asn Ile Ile Ile Thr Asp Val Thr
    530                 535                 540                 
Ala Asn Cys Leu Thr Val Thr Phe Lys Glu Tyr Val Thr Val
545                 550                 555             


<210> 393
<211> 560
<212> PRT
<213> Homo sapiens

<400> 393
Met Pro Gln Thr Arg Ser Gln Ala Gln Ala Thr Ile Ser Phe Pro Lys
 1               5                  10                  15      
Arg Lys Leu Ser Arg Ala Leu Asn Lys Ala Lys Asn Ser Ser Asp Ala
            20                  25                  30          
Lys Leu Glu Pro Thr Asn Val Gln Thr Val Thr Cys Ser Pro Arg Val
        35                  40                  45              
Lys Ala Leu Pro Leu Ser Pro Arg Lys Arg Leu Gly Asp Asp Asn Leu
    50                  55                  60                  
Cys Asn Thr Pro His Leu Pro Pro Cys Ser Pro Pro Lys Gln Gly Lys
65                  70                  75                  80  
Lys Glu Asn Gly Pro Pro His Ser His Thr Leu Lys Gly Arg Arg Leu
                85                  90                  95      
Val Phe Asp Asn Gln Leu Thr Ile Lys Ser Pro Ser Lys Arg Glu Leu
            100                 105                 110         
Ala Lys Val His Gln Asn Lys Ile Leu Ser Ser Val Arg Lys Ser Gln
        115                 120                 125             
Glu Ile Thr Thr Asn Ser Glu Gln Arg Cys Pro Leu Lys Lys Glu Ser
    130                 135                 140                 
Ala Cys Val Arg Leu Phe Lys Gln Glu Gly Thr Cys Tyr Gln Gln Ala
145                 150                 155                 160 
Lys Leu Val Leu Asn Thr Ala Val Pro Asp Arg Leu Pro Ala Arg Glu
                165                 170                 175     
Arg Glu Met Asp Val Ile Arg Asn Phe Leu Arg Glu His Ile Cys Gly
            180                 185                 190         
Lys Lys Ala Gly Ser Leu Tyr Leu Ser Gly Ala Pro Gly Thr Gly Lys
        195                 200                 205             
Thr Ala Cys Leu Ser Arg Ile Leu Gln Asp Leu Lys Lys Glu Leu Lys
    210                 215                 220                 
Gly Phe Lys Thr Ile Met Leu Asn Cys Met Ser Leu Arg Thr Ala Gln
225                 230                 235                 240 
Ala Val Phe Pro Ala Ile Ala Gln Glu Ile Cys Gln Glu Glu Val Ser
                245                 250                 255     
Arg Pro Ala Gly Lys Asp Met Met Arg Lys Leu Glu Lys His Met Thr
            260                 265                 270         
Ala Glu Lys Gly Pro Met Ile Val Leu Val Leu Asp Glu Met Asp Gln
        275                 280                 285             
Leu Asp Ser Lys Gly Gln Asp Val Leu Tyr Thr Leu Phe Glu Trp Pro
    290                 295                 300                 
Trp Leu Ser Asn Ser His Leu Val Leu Ile Gly Ile Ala Asn Thr Leu
305                 310                 315                 320 
Asp Leu Thr Asp Arg Ile Leu Pro Arg Leu Gln Ala Arg Glu Lys Cys
                325                 330                 335     
Lys Pro Gln Leu Leu Asn Phe Pro Pro Tyr Thr Arg Asn Gln Ile Val
            340                 345                 350         
Thr Ile Leu Gln Asp Arg Leu Asn Gln Val Ser Arg Asp Gln Val Leu
        355                 360                 365             
Asp Asn Ala Ala Val Gln Phe Cys Ala Arg Lys Val Ser Ala Val Ser
    370                 375                 380                 
Gly Asp Val Arg Lys Ala Leu Asp Val Cys Arg Arg Ala Ile Glu Ile
385                 390                 395                 400 
Val Glu Ser Asp Val Lys Ser Gln Thr Ile Leu Lys Pro Leu Ser Glu
                405                 410                 415     
Cys Lys Ser Pro Ser Glu Pro Leu Ile Pro Lys Arg Val Gly Leu Ile
            420                 425                 430         
His Ile Ser Gln Val Ile Ser Glu Val Asp Gly Asn Arg Met Thr Leu
        435                 440                 445             
Ser Gln Glu Gly Ala Gln Asp Ser Phe Pro Leu Gln Gln Lys Ile Leu
    450                 455                 460                 
Val Cys Ser Leu Met Leu Leu Ile Arg Gln Leu Lys Ile Lys Glu Val
465                 470                 475                 480 
Thr Leu Gly Lys Leu Tyr Glu Ala Tyr Ser Lys Val Cys Arg Lys Gln
                485                 490                 495     
Gln Val Ala Ala Val Asp Gln Ser Glu Cys Leu Ser Leu Ser Gly Leu
            500                 505                 510         
Leu Glu Ala Arg Gly Ile Leu Gly Leu Lys Arg Asn Lys Glu Thr Arg
        515                 520                 525             
Leu Thr Lys Val Phe Phe Lys Ile Glu Glu Lys Glu Ile Glu His Ala
    530                 535                 540                 
Leu Lys Asp Lys Ala Leu Ile Gly Asn Ile Leu Ala Thr Gly Leu Pro
545                 550                 555                 560 


<210> 394
<211> 713
<212> PRT
<213> Homo sapiens

<400> 394
Met Gln Pro Arg Thr Pro Leu Val Leu Cys Val Leu Leu Ser Gln Val
 1               5                  10                  15      
Leu Leu Leu Thr Ser Ala Glu Asp Leu Asp Cys Thr Pro Gly Phe Gln
            20                  25                  30          
Gln Lys Val Phe His Ile Asn Gln Pro Ala Glu Phe Ile Glu Asp Gln
        35                  40                  45              
Ser Ile Leu Asn Leu Thr Phe Ser Asp Cys Lys Gly Asn Asp Lys Leu
    50                  55                  60                  
Arg Tyr Glu Val Ser Ser Pro Tyr Phe Lys Val Asn Ser Asp Gly Gly
65                  70                  75                  80  
Leu Val Ala Leu Arg Asn Ile Thr Ala Val Gly Lys Thr Leu Phe Val
                85                  90                  95      
His Ala Arg Thr Pro His Ala Glu Asp Met Ala Glu Leu Val Ile Val
            100                 105                 110         
Gly Gly Lys Asp Ile Gln Gly Ser Leu Gln Asp Ile Phe Lys Phe Ala
        115                 120                 125             
Arg Thr Ser Pro Val Pro Arg Gln Lys Arg Ser Ile Val Val Ser Pro
    130                 135                 140                 
Ile Leu Ile Pro Glu Asn Gln Arg Gln Pro Phe Pro Arg Asp Val Gly
145                 150                 155                 160 
Lys Val Val Asp Ser Asp Arg Pro Glu Arg Ser Lys Phe Arg Leu Thr
                165                 170                 175     
Gly Lys Gly Val Asp Gln Glu Pro Lys Gly Ile Phe Arg Ile Asn Glu
            180                 185                 190         
Asn Thr Gly Ser Val Ser Val Thr Arg Thr Leu Asp Arg Glu Val Ile
        195                 200                 205             
Ala Val Tyr Gln Leu Phe Val Glu Thr Thr Asp Val Asn Gly Lys Thr
    210                 215                 220                 
Leu Glu Gly Pro Val Pro Leu Glu Val Ile Val Ile Asp Gln Asn Asp
225                 230                 235                 240 
Asn Arg Pro Ile Phe Arg Glu Gly Pro Tyr Ile Gly His Val Met Glu
                245                 250                 255     
Gly Ser Pro Thr Gly Thr Thr Val Met Arg Met Thr Ala Phe Asp Ala
            260                 265                 270         
Asp Asp Pro Ala Thr Asp Asn Ala Leu Leu Arg Tyr Asn Ile Arg Gln
        275                 280                 285             
Gln Thr Pro Asp Lys Pro Ser Pro Asn Met Phe Tyr Ile Asp Pro Glu
    290                 295                 300                 
Lys Gly Asp Ile Val Thr Val Val Ser Pro Ala Leu Leu Asp Arg Glu
305                 310                 315                 320 
Thr Leu Glu Asn Pro Lys Tyr Glu Leu Ile Ile Glu Ala Gln Asp Met
                325                 330                 335     
Ala Gly Leu Asp Val Gly Leu Thr Gly Thr Ala Thr Ala Thr Ile Met
            340                 345                 350         
Ile Asp Asp Lys Asn Asp His Ser Pro Lys Phe Thr Lys Lys Glu Phe
        355                 360                 365             
Gln Ala Thr Val Glu Glu Gly Ala Val Gly Val Ile Val Asn Leu Thr
    370                 375                 380                 
Val Glu Asp Lys Asp Asp Pro Thr Thr Gly Ala Trp Arg Ala Ala Tyr
385                 390                 395                 400 
Thr Ile Ile Asn Gly Asn Pro Gly Gln Ser Phe Glu Ile His Thr Asn
                405                 410                 415     
Pro Gln Thr Asn Glu Gly Met Leu Ser Val Val Lys Pro Leu Asp Tyr
            420                 425                 430         
Glu Ile Ser Ala Phe His Thr Leu Leu Ile Lys Val Glu Asn Glu Asp
        435                 440                 445             
Pro Leu Val Pro Asp Val Ser Tyr Gly Pro Ser Ser Thr Ala Thr Val
    450                 455                 460                 
His Ile Thr Val Leu Asp Val Asn Glu Gly Pro Val Phe Tyr Pro Asp
465                 470                 475                 480 
Pro Met Met Val Thr Arg Gln Glu Asp Leu Ser Val Gly Ser Val Leu
                485                 490                 495     
Leu Thr Val Asn Ala Thr Asp Pro Asp Ser Leu Gln His Gln Thr Ile
            500                 505                 510         
Arg Tyr Ser Val Tyr Lys Asp Pro Ala Gly Trp Leu Asn Ile Asn Pro
        515                 520                 525             
Ile Asn Gly Thr Val Asp Thr Thr Ala Val Leu Asp Arg Glu Ser Pro
    530                 535                 540                 
Phe Val Asp Asn Ser Val Tyr Thr Ala Leu Phe Leu Ala Ile Asp Ser
545                 550                 555                 560 
Gly Asn Pro Pro Ala Thr Gly Thr Gly Thr Leu Leu Ile Thr Leu Glu
                565                 570                 575     
Asp Val Asn Asp Asn Ala Pro Phe Ile Tyr Pro Thr Val Ala Glu Val
            580                 585                 590         
Cys Asp Asp Ala Lys Asn Leu Ser Val Val Ile Leu Gly Ala Ser Asp
        595                 600                 605             
Lys Asp Leu His Pro Asn Thr Asp Pro Phe Lys Phe Glu Ile His Lys
    610                 615                 620                 
Gln Ala Val Pro Asp Lys Val Trp Lys Ile Ser Lys Ile Asn Asn Thr
625                 630                 635                 640 
His Ala Leu Val Ser Leu Leu Gln Asn Leu Asn Lys Ala Asn Tyr Asn
                645                 650                 655     
Leu Pro Ile Met Val Thr Asp Ser Gly Lys Pro Pro Met Thr Asn Ile
            660                 665                 670         
Thr Asp Leu Arg Val Gln Val Cys Ser Cys Arg Asn Ser Lys Val Asp
        675                 680                 685             
Cys Asn Ala Ala Gly Ala Leu Arg Phe Ser Leu Pro Ser Val Leu Leu
    690                 695                 700                 
Leu Ser Leu Phe Ser Leu Ala Cys Leu
705                 710             


<210> 395
<211> 411
<212> PRT
<213> Homo sapiens

<400> 395
Met Gln Cys Ser Trp Lys Ala Val Leu Leu Leu Ala Leu Ala Ser Ile
 1               5                  10                  15      
Ala Ile Gln Tyr Thr Ala Ile Arg Thr Phe Thr Ala Lys Ser Phe His
            20                  25                  30          
Thr Cys Pro Gly Leu Ala Glu Ala Gly Leu Ala Glu Arg Leu Cys Glu
        35                  40                  45              
Glu Ser Pro Thr Phe Ala Tyr Asn Leu Ser Arg Lys Thr His Ile Leu
    50                  55                  60                  
Ile Leu Ala Thr Thr Arg Ser Gly Ser Ser Phe Val Gly Gln Leu Phe
65                  70                  75                  80  
Asn Gln His Leu Asp Val Phe Tyr Leu Phe Glu Pro Leu Tyr His Val
                85                  90                  95      
Gln Asn Thr Leu Ile Pro Arg Phe Thr Gln Gly Lys Ser Pro Ala Asp
            100                 105                 110         
Arg Arg Val Met Leu Gly Ala Ser Arg Asp Leu Leu Arg Ser Leu Tyr
        115                 120                 125             
Asp Cys Asp Leu Tyr Phe Leu Glu Asn Tyr Ile Lys Pro Pro Pro Val
    130                 135                 140                 
Asn His Thr Thr Asp Arg Ile Phe Arg Arg Gly Ala Ser Arg Val Leu
145                 150                 155                 160 
Cys Ser Arg Pro Val Cys Asp Pro Pro Gly Pro Ala Asp Leu Val Leu
                165                 170                 175     
Glu Glu Gly Asp Cys Val Arg Lys Cys Gly Leu Leu Asn Leu Thr Val
            180                 185                 190         
Ala Ala Glu Ala Cys Arg Glu Arg Ser His Val Ala Ile Lys Thr Val
        195                 200                 205             
Arg Val Pro Glu Val Asn Asp Leu Arg Ala Leu Val Glu Asp Pro Arg
    210                 215                 220                 
Leu Asn Leu Lys Val Ile Gln Leu Val Arg Asp Pro Arg Gly Ile Leu
225                 230                 235                 240 
Ala Ser Arg Ser Glu Thr Phe Arg Asp Thr Tyr Arg Leu Trp Arg Leu
                245                 250                 255     
Trp Tyr Gly Thr Gly Arg Lys Pro Tyr Asn Leu Asp Val Thr Gln Leu
            260                 265                 270         
Thr Thr Val Cys Glu Asp Phe Ser Asn Ser Val Ser Thr Gly Leu Met
        275                 280                 285             
Arg Pro Pro Trp Leu Lys Gly Lys Tyr Met Leu Val Arg Tyr Glu Asp
    290                 295                 300                 
Leu Ala Arg Asn Pro Met Lys Lys Thr Glu Glu Ile Tyr Gly Phe Leu
305                 310                 315                 320 
Gly Ile Pro Leu Asp Ser His Val Ala Arg Trp Ile Gln Asn Asn Thr
                325                 330                 335     
Arg Gly Asp Pro Thr Leu Gly Lys His Lys Tyr Gly Thr Val Arg Asn
            340                 345                 350         
Ser Ala Ala Thr Ala Glu Lys Trp Arg Phe Arg Leu Ser Tyr Asp Ile
        355                 360                 365             
Val Ala Phe Ala Gln Asn Ala Cys Gln Gln Val Leu Ala Gln Leu Gly
    370                 375                 380                 
Tyr Lys Ile Ala Ala Ser Glu Glu Glu Leu Lys Asn Pro Ser Val Ser
385                 390                 395                 400 
Leu Val Glu Glu Arg Asp Phe Arg Pro Phe Ser
                405                 410     


<210> 396
<211> 419
<212> PRT
<213> Homo sapiens

<400> 396
Met Ala Ser Ile Phe Ser Lys Leu Leu Thr Gly Arg Asn Ala Ser Leu
 1               5                  10                  15      
Leu Phe Ala Thr Met Gly Thr Ser Val Leu Thr Thr Gly Tyr Leu Leu
            20                  25                  30          
Asn Arg Gln Lys Val Cys Ala Glu Val Arg Glu Gln Pro Arg Leu Phe
        35                  40                  45              
Pro Pro Ser Ala Asp Tyr Pro Asp Leu Arg Lys His Asn Asn Cys Met
    50                  55                  60                  
Ala Glu Cys Leu Thr Pro Ala Ile Tyr Ser Lys Leu Arg Asn Lys Val
65                  70                  75                  80  
Thr Pro Asn Gly Tyr Thr Leu Asp Gln Cys Ile Gln Thr Gly Val Asp
                85                  90                  95      
Asn Pro Gly His Pro Phe Ile Lys Thr Val Gly Met Val Ala Gly Asp
            100                 105                 110         
Glu Glu Ser Tyr Glu Val Phe Ala Asp Leu Phe Asp Pro Val Ile Lys
        115                 120                 125             
Leu Arg His Asn Gly Tyr Asp Pro Arg Val Met Lys His Thr Thr Asp
    130                 135                 140                 
Leu Asp Ala Ser Lys Ile Thr Gln Gly Gln Phe Asp Glu His Tyr Val
145                 150                 155                 160 
Leu Ser Ser Arg Val Arg Thr Gly Arg Ser Ile Arg Gly Leu Ser Leu
                165                 170                 175     
Pro Pro Ala Cys Thr Arg Ala Glu Arg Arg Glu Val Glu Asn Val Ala
            180                 185                 190         
Ile Thr Ala Leu Glu Gly Leu Lys Gly Asp Leu Ala Gly Arg Tyr Tyr
        195                 200                 205             
Lys Leu Ser Glu Met Thr Glu Gln Asp Gln Gln Arg Leu Ile Asp Asp
    210                 215                 220                 
His Phe Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Thr Cys Ala Gly
225                 230                 235                 240 
Met Ala Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Tyr Asp
                245                 250                 255     
Lys Thr Phe Leu Ile Trp Ile Asn Glu Glu Asp His Thr Arg Val Ile
            260                 265                 270         
Ser Met Glu Lys Gly Gly Asn Met Lys Arg Val Phe Glu Arg Phe Cys
        275                 280                 285             
Arg Gly Leu Lys Glu Val Glu Arg Leu Ile Gln Glu Arg Gly Trp Glu
    290                 295                 300                 
Phe Met Trp Asn Glu Arg Leu Gly Tyr Ile Leu Thr Cys Pro Ser Asn
305                 310                 315                 320 
Leu Gly Thr Gly Leu Arg Ala Gly Val His Val Arg Ile Pro Lys Leu
                325                 330                 335     
Ser Lys Asp Pro Arg Phe Ser Lys Ile Leu Glu Asn Leu Arg Leu Gln
            340                 345                 350         
Lys Arg Gly Thr Gly Gly Val Asp Thr Ala Ala Val Ala Asp Val Tyr
        355                 360                 365             
Asp Ile Ser Asn Ile Asp Arg Ile Gly Arg Ser Glu Val Glu Leu Val
    370                 375                 380                 
Gln Ile Val Ile Asp Gly Val Asn Tyr Leu Val Asp Cys Glu Lys Lys
385                 390                 395                 400 
Leu Glu Arg Gly Gln Asp Ile Lys Val Pro Pro Pro Leu Pro Gln Phe
                405                 410                 415     
Gly Lys Lys
            


<210> 397
<211> 86
<212> PRT
<213> Homo sapiens

<400> 397
Met Ala Glu Asp Met Glu Thr Lys Ile Lys Asn Tyr Lys Thr Ala Pro
 1               5                  10                  15      
Phe Asp Ser Arg Phe Pro Asn Gln Asn Gln Thr Arg Asn Cys Trp Gln
            20                  25                  30          
Asn Tyr Leu Asp Phe His Arg Cys Gln Lys Ala Met Thr Ala Lys Gly
        35                  40                  45              
Gly Asp Ile Ser Val Cys Glu Trp Tyr Gln Arg Val Tyr Gln Ser Leu
    50                  55                  60                  
Cys Pro Thr Ser Trp Val Thr Asp Trp Asp Glu Gln Arg Ala Glu Gly
65                  70                  75                  80  
Thr Phe Pro Gly Lys Ile
                85      


<210> 398
<211> 79
<212> PRT
<213> Homo sapiens

<400> 398
Met Gln Ala Leu Arg Val Ser Gln Ala Leu Ile Arg Ser Phe Ser Ser
 1               5                  10                  15      
Thr Ala Arg Asn Arg Phe Gln Asn Arg Val Arg Glu Lys Gln Lys Leu
            20                  25                  30          
Phe Gln Glu Asp Asn Asp Ile Pro Leu Tyr Leu Lys Gly Gly Ile Val
        35                  40                  45              
Asp Asn Ile Leu Tyr Arg Val Thr Met Thr Leu Cys Leu Gly Gly Thr
    50                  55                  60                  
Val Tyr Ser Leu Tyr Ser Leu Gly Trp Ala Ser Phe Pro Arg Asn
65                  70                  75                  


<210> 399
<211> 83
<212> PRT
<213> Homo sapiens

<400> 399
Met Leu Arg Asn Leu Leu Ala Leu Arg Gln Ile Gly Gln Arg Thr Ile
 1               5                  10                  15      
Ser Thr Ala Ser Arg Arg His Phe Lys Asn Lys Val Pro Glu Lys Gln
            20                  25                  30          
Lys Leu Phe Gln Glu Asp Asp Glu Ile Pro Leu Tyr Leu Lys Gly Gly
        35                  40                  45              
Val Ala Asp Ala Leu Leu Tyr Arg Ala Thr Met Ile Leu Thr Val Gly
    50                  55                  60                  
Gly Thr Ala Tyr Ala Ile Tyr Glu Leu Ala Val Ala Ser Phe Pro Lys
65                  70                  75                  80  
Lys Gln Glu
            


<210> 400
<211> 80
<212> PRT
<213> Homo sapiens

<400> 400
Met Phe Pro Leu Val Lys Ser Ala Leu Asn Arg Leu Gln Val Arg Ser
 1               5                  10                  15      
Ile Gln Gln Thr Met Ala Arg Gln Ser His Gln Lys Arg Thr Pro Asp
            20                  25                  30          
Phe His Asp Lys Tyr Gly Asn Ala Val Leu Ala Ser Gly Ala Thr Phe
        35                  40                  45              
Cys Ile Val Thr Trp Thr Tyr Val Ala Thr Gln Val Gly Ile Glu Trp
    50                  55                  60                  
Asn Leu Ser Pro Val Gly Arg Val Thr Pro Lys Glu Trp Arg Asn Gln
65                  70                  75                  80  


<210> 401
<211> 63
<212> PRT
<213> Homo sapiens

<400> 401
Met Leu Gly Gln Ser Ile Arg Arg Phe Thr Thr Ser Val Val Arg Arg
 1               5                  10                  15      
Ser His Tyr Glu Glu Gly Pro Gly Lys Asn Leu Pro Phe Ser Val Glu
            20                  25                  30          
Asn Lys Trp Ser Leu Leu Ala Lys Met Cys Leu Tyr Phe Gly Ser Ala
        35                  40                  45              
Phe Ala Thr Pro Phe Leu Val Val Arg His Gln Leu Leu Lys Thr
    50                  55                  60              


<210> 402
<211> 537
<212> PRT
<213> Homo sapiens

<400> 402
Met Ala Ala Gln Cys Val Thr Lys Val Ala Leu Asn Val Ser Cys Ala
 1               5                  10                  15      
Asn Leu Leu Asp Lys Asp Ile Gly Ser Lys Ser Asp Pro Leu Cys Val
            20                  25                  30          
Leu Phe Leu Asn Thr Ser Gly Gln Gln Trp Tyr Glu Val Glu Arg Thr
        35                  40                  45              
Glu Arg Ile Lys Asn Cys Leu Asn Pro Gln Phe Ser Lys Thr Phe Ile
    50                  55                  60                  
Ile Asp Tyr Tyr Phe Glu Val Val Gln Lys Leu Lys Phe Gly Val Tyr
65                  70                  75                  80  
Asp Ile Asp Asn Lys Thr Ile Glu Leu Ser Asp Asp Asp Phe Leu Gly
                85                  90                  95      
Glu Cys Glu Cys Thr Leu Gly Gln Ile Val Ser Ser Lys Lys Leu Thr
            100                 105                 110         
Arg Pro Leu Val Met Lys Thr Gly Arg Pro Ala Gly Lys Gly Ser Ile
        115                 120                 125             
Thr Ile Ser Ala Glu Glu Ile Lys Asp Asn Arg Val Val Leu Phe Glu
    130                 135                 140                 
Met Glu Ala Arg Lys Leu Asp Asn Lys Asp Leu Phe Gly Lys Ser Asp
145                 150                 155                 160 
Pro Tyr Leu Glu Phe His Lys Gln Thr Ser Asp Gly Asn Trp Leu Met
                165                 170                 175     
Val His Arg Thr Glu Val Val Lys Asn Asn Leu Asn Pro Val Trp Arg
            180                 185                 190         
Pro Phe Lys Ile Ser Leu Asn Ser Leu Cys Tyr Gly Asp Met Asp Lys
        195                 200                 205             
Thr Ile Lys Val Glu Cys Tyr Asp Tyr Asp Asn Asp Gly Ser His Asp
    210                 215                 220                 
Leu Ile Gly Thr Phe Gln Thr Thr Met Thr Lys Leu Lys Glu Ala Ser
225                 230                 235                 240 
Arg Ser Ser Pro Val Glu Phe Glu Cys Ile Asn Glu Lys Lys Arg Gln
                245                 250                 255     
Lys Lys Lys Ser Tyr Lys Asn Ser Gly Val Ile Ser Val Lys Gln Cys
            260                 265                 270         
Glu Ile Thr Val Glu Cys Thr Phe Leu Asp Tyr Ile Met Gly Gly Cys
        275                 280                 285             
Gln Leu Asn Phe Thr Val Gly Val Asp Phe Thr Gly Ser Asn Gly Asp
    290                 295                 300                 
Pro Arg Ser Pro Asp Ser Leu His Tyr Ile Ser Pro Asn Gly Val Asn
305                 310                 315                 320 
Glu Tyr Leu Thr Ala Leu Trp Ser Val Gly Leu Val Ile Gln Asp Tyr
                325                 330                 335     
Asp Ala Asp Lys Met Phe Pro Ala Phe Gly Phe Gly Ala Gln Ile Pro
            340                 345                 350         
Pro Gln Trp Gln Val Ser His Glu Phe Pro Met Asn Phe Asn Pro Ser
        355                 360                 365             
Asn Pro Tyr Cys Asn Gly Ile Gln Gly Ile Val Glu Ala Tyr Arg Ser
    370                 375                 380                 
Cys Leu Pro Gln Ile Lys Leu Tyr Gly Pro Thr Asn Phe Ser Pro Ile
385                 390                 395                 400 
Ile Asn His Val Ala Arg Phe Ala Ala Ala Ala Thr Gln Gln Gln Thr
                405                 410                 415     
Ala Ser Gln Tyr Phe Val Leu Leu Ile Ile Thr Asp Gly Val Ile Thr
            420                 425                 430         
Asp Leu Asp Glu Thr Arg Gln Ala Ile Val Asn Ala Ser Arg Leu Pro
        435                 440                 445             
Met Ser Ile Ile Ile Val Gly Val Gly Gly Ala Asp Phe Ser Ala Met
    450                 455                 460                 
Glu Phe Leu Asp Gly Asp Gly Gly Ser Leu Arg Ser Pro Leu Gly Glu
465                 470                 475                 480 
Val Ala Ile Arg Asp Ile Val Gln Phe Val Pro Phe Arg Gln Phe Gln
                485                 490                 495     
Asn Ala Pro Lys Glu Ala Leu Ala Gln Cys Val Leu Ala Glu Ile Pro
            500                 505                 510         
Gln Gln Val Val Gly Tyr Phe Asn Thr Tyr Lys Leu Leu Pro Pro Lys
        515                 520                 525             
Asn Pro Ala Thr Lys Gln Gln Lys Gln
    530                 535         


<210> 403
<211> 773
<212> PRT
<213> Homo sapiens

<400> 403
Met Ala Glu Ala His Gln Ala Val Ala Phe Gln Phe Thr Val Thr Pro
 1               5                  10                  15      
Asp Gly Ile Asp Leu Arg Leu Ser His Glu Ala Leu Arg Gln Ile Tyr
            20                  25                  30          
Leu Ser Gly Leu His Ser Trp Lys Lys Lys Phe Ile Arg Phe Lys Asn
        35                  40                  45              
Gly Ile Ile Thr Gly Val Tyr Pro Ala Ser Pro Ser Ser Trp Leu Ile
    50                  55                  60                  
Val Val Val Gly Val Met Thr Thr Met Tyr Ala Lys Ile Asp Pro Ser
65                  70                  75                  80  
Leu Gly Ile Ile Ala Lys Ile Asn Arg Thr Leu Glu Thr Ala Asn Cys
                85                  90                  95      
Met Ser Ser Gln Thr Lys Asn Val Val Ser Gly Val Leu Phe Gly Thr
            100                 105                 110         
Gly Leu Trp Val Ala Leu Ile Val Thr Met Arg Tyr Ser Leu Lys Val
        115                 120                 125             
Leu Leu Ser Tyr His Gly Trp Met Phe Thr Glu His Gly Lys Met Ser
    130                 135                 140                 
Arg Ala Thr Lys Ile Trp Met Gly Met Val Lys Ile Phe Ser Gly Arg
145                 150                 155                 160 
Lys Pro Met Leu Tyr Ser Phe Gln Thr Ser Leu Pro Arg Leu Pro Val
                165                 170                 175     
Pro Ala Val Lys Asp Thr Val Asn Arg Tyr Leu Gln Ser Val Arg Pro
            180                 185                 190         
Leu Met Lys Glu Glu Asp Phe Lys Arg Met Thr Ala Leu Ala Gln Asp
        195                 200                 205             
Phe Ala Val Gly Leu Gly Pro Arg Leu Gln Trp Tyr Leu Lys Leu Lys
    210                 215                 220                 
Ser Trp Trp Ala Thr Asn Tyr Val Ser Asp Trp Trp Glu Glu Tyr Ile
225                 230                 235                 240 
Tyr Leu Arg Gly Arg Gly Pro Leu Met Val Asn Ser Asn Tyr Tyr Ala
                245                 250                 255     
Met Asp Leu Leu Tyr Ile Leu Pro Thr His Ile Gln Ala Ala Arg Ala
            260                 265                 270         
Gly Asn Ala Ile His Ala Ile Leu Leu Tyr Arg Arg Lys Leu Asp Arg
        275                 280                 285             
Glu Glu Ile Lys Pro Ile Arg Leu Leu Gly Ser Thr Ile Pro Leu Cys
    290                 295                 300                 
Ser Ala Gln Trp Glu Arg Met Phe Asn Thr Ser Arg Ile Pro Gly Glu
305                 310                 315                 320 
Glu Thr Asp Thr Ile Gln His Met Arg Asp Ser Lys His Ile Val Val
                325                 330                 335     
Tyr His Arg Gly Arg Tyr Phe Lys Val Trp Leu Tyr His Asp Gly Arg
            340                 345                 350         
Leu Leu Lys Pro Arg Glu Met Glu Gln Gln Met Gln Arg Ile Leu Asp
        355                 360                 365             
Asn Thr Ser Glu Pro Gln Pro Gly Glu Ala Arg Leu Ala Ala Leu Thr
    370                 375                 380                 
Ala Gly Asp Arg Val Pro Trp Ala Arg Cys Arg Gln Ala Tyr Phe Gly
385                 390                 395                 400 
Arg Gly Lys Asn Lys Gln Ser Leu Asp Ala Val Glu Lys Ala Ala Phe
                405                 410                 415     
Phe Val Thr Leu Asp Glu Thr Glu Glu Gly Tyr Arg Ser Glu Asp Pro
            420                 425                 430         
Asp Thr Ser Met Asp Ser Tyr Ala Lys Ser Leu Leu His Gly Arg Cys
        435                 440                 445             
Tyr Asp Arg Trp Phe Asp Lys Ser Phe Thr Phe Val Val Phe Lys Asn
    450                 455                 460                 
Gly Lys Met Gly Leu Asn Ala Glu His Ser Trp Ala Asp Ala Gln Ile
465                 470                 475                 480 
Val Ala His Leu Trp Glu Tyr Val Met Ser Ile Asp Ser Leu Gln Leu
                485                 490                 495     
Gly Tyr Ala Glu Asp Gly His Cys Lys Gly Asp Ile Asn Pro Asn Ile
            500                 505                 510         
Pro Tyr Pro Thr Arg Leu Gln Trp Asp Ile Pro Gly Glu Cys Gln Glu
        515                 520                 525             
Val Ile Glu Thr Ser Leu Asn Thr Ala Asn Leu Leu Ala Asn Asp Val
    530                 535                 540                 
Asp Phe His Ser Phe Pro Phe Val Ala Phe Gly Lys Gly Ile Ile Lys
545                 550                 555                 560 
Lys Cys Arg Thr Ser Pro Asp Thr Phe Val Gln Leu Ala Leu Gln Leu
                565                 570                 575     
Ala His Tyr Lys Asp Met Gly Lys Phe Cys Leu Thr Tyr Glu Ala Ser
            580                 585                 590         
Met Thr Arg Leu Phe Arg Glu Gly Arg Thr Glu Thr Val Arg Ser Cys
        595                 600                 605             
Thr Thr Glu Ser Cys Asp Phe Val Arg Ala Met Val Asp Pro Ala Gln
    610                 615                 620                 
Thr Val Glu Gln Arg Leu Lys Leu Phe Lys Leu Ala Ser Glu Lys His
625                 630                 635                 640 
Gln His Met Tyr Arg Leu Ala Met Thr Gly Ser Gly Ile Asp Arg His
                645                 650                 655     
Leu Phe Cys Leu Tyr Val Val Ser Lys Tyr Leu Ala Val Glu Ser Pro
            660                 665                 670         
Phe Leu Lys Glu Val Leu Ser Glu Pro Trp Arg Leu Ser Thr Ser Gln
        675                 680                 685             
Thr Pro Gln Gln Gln Val Glu Leu Phe Asp Leu Glu Asn Asn Pro Glu
    690                 695                 700                 
Tyr Val Ser Ser Gly Gly Gly Phe Gly Pro Val Ala Asp Asp Gly Tyr
705                 710                 715                 720 
Gly Val Ser Tyr Ile Leu Val Gly Glu Asn Leu Ile Asn Phe His Ile
                725                 730                 735     
Ser Ser Lys Phe Ser Cys Pro Glu Thr Asp Ser His Arg Phe Gly Arg
            740                 745                 750         
His Leu Lys Glu Ala Met Thr Asp Ile Ile Thr Leu Phe Gly Leu Ser
        755                 760                 765             
Ser Asn Ser Lys Lys
    770             


<210> 404
<211> 208
<212> PRT
<213> Homo sapiens

<400> 404
Met Ala Ser Lys Cys Pro Lys Cys Asp Lys Thr Val Tyr Phe Ala Glu
 1               5                  10                  15      
Lys Val Ser Ser Leu Gly Lys Asp Trp His Lys Phe Cys Leu Lys Cys
            20                  25                  30          
Glu Arg Cys Ser Lys Thr Leu Thr Pro Gly Gly His Ala Glu His Asp
        35                  40                  45              
Gly Lys Pro Phe Cys His Lys Pro Cys Tyr Ala Thr Leu Phe Gly Pro
    50                  55                  60                  
Lys Gly Val Asn Ile Gly Gly Ala Gly Ser Tyr Ile Tyr Glu Lys Pro
65                  70                  75                  80  
Leu Ala Glu Gly Pro Gln Val Thr Gly Pro Ile Glu Val Pro Ala Ala
                85                  90                  95      
Arg Ala Glu Glu Arg Lys Ala Ser Gly Pro Pro Lys Gly Pro Ser Arg
            100                 105                 110         
Ala Ser Ser Val Thr Thr Phe Thr Gly Glu Pro Asn Thr Cys Pro Arg
        115                 120                 125             
Cys Ser Lys Lys Val Tyr Phe Ala Glu Lys Val Thr Ser Leu Gly Lys
    130                 135                 140                 
Asp Trp His Arg Pro Cys Leu Arg Cys Glu Arg Cys Gly Lys Thr Leu
145                 150                 155                 160 
Thr Pro Gly Gly His Ala Glu His Asp Gly Gln Pro Tyr Cys His Lys
                165                 170                 175     
Pro Cys Tyr Gly Ile Leu Phe Gly Pro Lys Gly Val Asn Thr Gly Ala
            180                 185                 190         
Val Gly Ser Tyr Ile Tyr Asp Arg Asp Pro Glu Gly Lys Val Gln Pro
        195                 200                 205             


<210> 405
<211> 175
<212> PRT
<213> Homo sapiens

<400> 405
Met Asp Ile Ala Ile His His Pro Trp Ile Arg Arg Pro Phe Phe Pro
 1               5                  10                  15      
Phe His Ser Pro Ser Arg Leu Phe Asp Gln Phe Phe Gly Glu His Leu
            20                  25                  30          
Leu Glu Ser Asp Leu Phe Pro Thr Ser Thr Ser Leu Ser Pro Phe Tyr
        35                  40                  45              
Leu Arg Pro Pro Ser Phe Leu Arg Ala Pro Ser Trp Phe Asp Thr Gly
    50                  55                  60                  
Leu Ser Glu Met Arg Leu Glu Lys Asp Arg Phe Ser Val Asn Leu Asp
65                  70                  75                  80  
Val Lys His Phe Ser Pro Glu Glu Leu Lys Val Lys Val Leu Gly Asp
                85                  90                  95      
Val Ile Glu Val His Gly Lys His Glu Glu Arg Gln Asp Glu His Gly
            100                 105                 110         
Phe Ile Ser Arg Glu Phe His Arg Lys Tyr Arg Ile Pro Ala Asp Val
        115                 120                 125             
Asp Pro Leu Thr Ile Thr Ser Ser Leu Ser Ser Asp Gly Val Leu Thr
    130                 135                 140                 
Val Asn Gly Pro Arg Lys Gln Val Ser Gly Pro Glu Arg Thr Ile Pro
145                 150                 155                 160 
Ile Thr Arg Glu Glu Lys Pro Ala Val Thr Ala Ala Pro Lys Lys
                165                 170                 175 


<210> 406
<211> 412
<212> PRT
<213> Homo sapiens

<400> 406
Met Gln Pro Ser Ser Leu Leu Pro Leu Ala Leu Cys Leu Leu Ala Ala
 1               5                  10                  15      
Pro Ala Ser Ala Leu Val Arg Ile Pro Leu His Lys Phe Thr Ser Ile
            20                  25                  30          
Arg Arg Thr Met Ser Glu Val Gly Gly Ser Val Glu Asp Leu Ile Ala
        35                  40                  45              
Lys Gly Pro Val Ser Lys Tyr Ser Gln Ala Val Pro Ala Val Thr Glu
    50                  55                  60                  
Gly Pro Ile Pro Glu Val Leu Lys Asn Tyr Met Asp Ala Gln Tyr Tyr
65                  70                  75                  80  
Gly Glu Ile Gly Ile Gly Thr Pro Pro Gln Cys Phe Thr Val Val Phe
                85                  90                  95      
Asp Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Ile His Cys Lys Leu
            100                 105                 110         
Leu Asp Ile Ala Cys Trp Ile His His Lys Tyr Asn Ser Asp Lys Ser
        115                 120                 125             
Ser Thr Tyr Val Lys Asn Gly Thr Ser Phe Asp Ile His Tyr Gly Ser
    130                 135                 140                 
Gly Ser Leu Ser Gly Tyr Leu Ser Gln Asp Thr Val Ser Val Pro Cys
145                 150                 155                 160 
Gln Ser Ala Ser Ser Ala Ser Ala Leu Gly Gly Val Lys Val Glu Arg
                165                 170                 175     
Gln Val Phe Gly Glu Ala Thr Lys Gln Pro Gly Ile Thr Phe Ile Ala
            180                 185                 190         
Ala Lys Phe Asp Gly Ile Leu Gly Met Ala Tyr Pro Arg Ile Ser Val
        195                 200                 205             
Asn Asn Val Leu Pro Val Phe Asp Asn Leu Met Gln Gln Lys Leu Val
    210                 215                 220                 
Asp Gln Asn Ile Phe Ser Phe Tyr Leu Ser Arg Asp Pro Asp Ala Gln
225                 230                 235                 240 
Pro Gly Gly Glu Leu Met Leu Gly Gly Thr Asp Ser Lys Tyr Tyr Lys
                245                 250                 255     
Gly Ser Leu Ser Tyr Leu Asn Val Thr Arg Lys Ala Tyr Trp Gln Val
            260                 265                 270         
His Leu Asp Gln Val Glu Val Ala Ser Gly Leu Thr Leu Cys Lys Glu
        275                 280                 285             
Gly Cys Glu Ala Ile Val Asp Thr Gly Thr Ser Leu Met Val Gly Pro
    290                 295                 300                 
Val Asp Glu Val Arg Glu Leu Gln Lys Ala Ile Gly Ala Val Pro Leu
305                 310                 315                 320 
Ile Gln Gly Glu Tyr Met Ile Pro Cys Glu Lys Val Ser Thr Leu Pro
                325                 330                 335     
Ala Ile Thr Leu Lys Leu Gly Gly Lys Gly Tyr Lys Leu Ser Pro Glu
            340                 345                 350         
Asp Tyr Thr Leu Lys Val Ser Gln Ala Gly Lys Thr Leu Cys Leu Ser
        355                 360                 365             
Gly Phe Met Gly Met Asp Ile Pro Pro Pro Ser Gly Pro Leu Trp Ile
    370                 375                 380                 
Leu Gly Asp Val Phe Ile Gly Arg Tyr Tyr Thr Val Phe Asp Arg Asp
385                 390                 395                 400 
Asn Asn Arg Val Gly Phe Ala Glu Ala Ala Arg Leu
                405                 410         


<210> 407
<211> 410
<212> PRT
<213> Homo sapiens

<400> 407
Met Val Leu Lys Ala Glu His Thr Arg Ser Pro Ser Ala Thr Leu Pro
 1               5                  10                  15      
Ser Asn Val Pro Ser Cys Arg Ser Leu Ser Ser Ser Glu Asp Gly Pro
            20                  25                  30          
Ser Gly Pro Ser Ser Leu Ala Asp Gly Gly Leu Ala His Asn Leu Gln
        35                  40                  45              
Asp Ser Val Arg His Arg Ile Leu Tyr Leu Ser Glu Gln Leu Arg Val
    50                  55                  60                  
Glu Lys Ala Ser Arg Asp Gly Asn Thr Val Ser Tyr Leu Lys Leu Val
65                  70                  75                  80  
Ser Lys Ala Asp Arg His Gln Val Pro His Ile Gln Gln Ala Phe Glu
                85                  90                  95      
Lys Val Asn Gln Arg Ala Ser Ala Thr Ile Ala Gln Ile Glu His Arg
            100                 105                 110         
Leu His Gln Cys His Gln Gln Leu Gln Glu Leu Glu Glu Gly Cys Arg
        115                 120                 125             
Pro Glu Gly Leu Leu Leu Met Ala Glu Ser Asp Pro Ala Asn Cys Glu
    130                 135                 140                 
Pro Pro Ser Glu Lys Ala Leu Leu Ser Glu Pro Pro Glu Pro Gly Gly
145                 150                 155                 160 
Glu Asp Gly Pro Val Asn Leu Pro His Ala Ser Arg Pro Phe Ile Leu
                165                 170                 175     
Glu Ser Arg Phe Gln Ser Leu Gln Gln Gly Thr Cys Leu Glu Thr Glu
            180                 185                 190         
Asp Val Ala Gln Gln Gln Asn Leu Leu Leu Gln Lys Val Lys Ala Glu
        195                 200                 205             
Leu Glu Glu Ala Lys Arg Phe His Ile Ser Leu Gln Glu Ser Tyr His
    210                 215                 220                 
Ser Leu Lys Glu Arg Ser Leu Thr Asp Leu Gln Leu Leu Leu Glu Ser
225                 230                 235                 240 
Leu Gln Glu Glu Lys Cys Arg Gln Ala Leu Met Glu Glu Gln Val Asn
                245                 250                 255     
Gly Arg Leu Gln Gly Gln Leu Asn Glu Ile Tyr Asn Leu Lys His Asn
            260                 265                 270         
Leu Ala Cys Ser Glu Glu Arg Met Ala Tyr Leu Ser Tyr Glu Arg Ala
        275                 280                 285             
Lys Glu Ile Trp Glu Ile Thr Glu Thr Phe Lys Ser Arg Ile Ser Lys
    290                 295                 300                 
Leu Glu Met Leu Gln Gln Val Thr Gln Leu Glu Ala Ala Glu His Leu
305                 310                 315                 320 
Gln Ser Arg Pro Pro Gln Met Leu Phe Lys Phe Leu Ser Pro Arg Leu
                325                 330                 335     
Ser Leu Ala Thr Val Leu Leu Val Phe Val Ser Thr Leu Cys Ala Cys
            340                 345                 350         
Pro Ser Ser Leu Ile Ser Ser Arg Leu Cys Thr Cys Thr Met Leu Met
        355                 360                 365             
Leu Ile Gly Leu Gly Val Leu Ala Trp Gln Arg Trp Arg Ala Ile Pro
    370                 375                 380                 
Ala Thr Asp Trp Gln Glu Trp Val Pro Ser Arg Cys Arg Leu Tyr Ser
385                 390                 395                 400 
Lys Asp Ser Gly Pro Pro Ala Asp Gly Pro
                405                 410 


<210> 408
<211> 260
<212> PRT
<213> Homo sapiens

<400> 408
Met Ala Thr Pro Pro Lys Arg Ser Cys Pro Ser Phe Ser Ala Ser Ser
 1               5                  10                  15      
Glu Gly Thr Arg Ile Lys Lys Ile Ser Ile Glu Gly Asn Ile Ala Ala
            20                  25                  30          
Gly Lys Ser Thr Phe Val Asn Ile Leu Lys Gln Leu Cys Glu Asp Trp
        35                  40                  45              
Glu Val Val Pro Glu Pro Val Ala Arg Trp Cys Asn Val Gln Ser Thr
    50                  55                  60                  
Gln Asp Glu Phe Glu Glu Leu Thr Met Ser Gln Lys Asn Gly Gly Asn
65                  70                  75                  80  
Val Leu Gln Met Met Tyr Glu Lys Pro Glu Arg Trp Ser Phe Thr Phe
                85                  90                  95      
Gln Thr Tyr Ala Cys Leu Ser Arg Ile Arg Ala Gln Leu Ala Ser Leu
            100                 105                 110         
Asn Gly Lys Leu Lys Asp Ala Glu Lys Pro Val Leu Phe Phe Glu Arg
        115                 120                 125             
Ser Val Tyr Ser Asp Arg Tyr Ile Phe Ala Ser Asn Leu Tyr Glu Ser
    130                 135                 140                 
Glu Cys Met Asn Glu Thr Glu Trp Thr Ile Tyr Gln Asp Trp His Asp
145                 150                 155                 160 
Trp Met Asn Asn Gln Phe Gly Gln Ser Leu Glu Leu Asp Gly Ile Ile
                165                 170                 175     
Tyr Leu Gln Ala Thr Pro Glu Thr Cys Leu His Arg Ile Tyr Leu Arg
            180                 185                 190         
Gly Arg Asn Glu Glu Gln Gly Ile Pro Leu Glu Tyr Leu Glu Lys Leu
        195                 200                 205             
His Tyr Lys His Glu Ser Trp Leu Leu His Arg Thr Leu Lys Thr Asn
    210                 215                 220                 
Phe Asp Tyr Leu Gln Glu Val Pro Ile Leu Thr Leu Asp Val Asn Glu
225                 230                 235                 240 
Asp Phe Lys Asp Lys Tyr Glu Ser Leu Val Glu Lys Val Lys Glu Phe
                245                 250                 255     
Leu Ser Thr Leu
            260 


<210> 409
<211> 335
<212> PRT
<213> Homo sapiens

<400> 409
Met Lys Leu Pro Ala Arg Val Phe Phe Thr Leu Gly Ser Arg Leu Pro
 1               5                  10                  15      
Cys Gly Leu Ala Pro Arg Arg Phe Phe Ser Tyr Gly Thr Lys Ile Leu
            20                  25                  30          
Tyr Gln Asn Thr Glu Ala Leu Gln Ser Lys Phe Phe Ser Pro Leu Gln
        35                  40                  45              
Lys Ala Met Leu Pro Pro Asn Ser Phe Gln Gly Lys Val Ala Phe Ile
    50                  55                  60                  
Thr Gly Gly Gly Thr Gly Leu Gly Lys Gly Met Thr Thr Leu Leu Ser
65                  70                  75                  80  
Ser Leu Gly Ala Gln Cys Val Ile Ala Ser Arg Lys Met Asp Val Leu
                85                  90                  95      
Lys Ala Thr Ala Glu Gln Ile Ser Ser Gln Thr Gly Asn Lys Val His
            100                 105                 110         
Ala Ile Gln Cys Asp Val Arg Asp Pro Asp Met Val Gln Asn Thr Val
        115                 120                 125             
Ser Glu Leu Ile Lys Val Ala Gly His Pro Asn Ile Val Ile Asn Asn
    130                 135                 140                 
Ala Ala Gly Asn Phe Ile Ser Pro Thr Glu Arg Leu Ser Pro Asn Ala
145                 150                 155                 160 
Trp Lys Thr Ile Thr Asp Ile Val Leu Asn Gly Thr Ala Phe Val Thr
                165                 170                 175     
Leu Glu Ile Gly Lys Gln Leu Ile Lys Ala Gln Lys Gly Ala Ala Phe
            180                 185                 190         
Leu Ser Ile Thr Thr Ile Tyr Ala Glu Thr Gly Ser Gly Phe Val Val
        195                 200                 205             
Pro Ser Ala Ser Ala Lys Ala Gly Val Glu Ala Met Ser Lys Ser Leu
    210                 215                 220                 
Ala Ala Glu Trp Gly Lys Tyr Gly Met Arg Phe Asn Val Ile Gln Pro
225                 230                 235                 240 
Gly Pro Ile Lys Thr Lys Gly Ala Phe Ser Arg Leu Asp Pro Thr Gly
                245                 250                 255     
Thr Phe Glu Lys Glu Met Ile Gly Arg Ile Pro Cys Gly Arg Leu Gly
            260                 265                 270         
Thr Val Glu Glu Leu Ala Asn Leu Ala Ala Phe Leu Cys Ser Asp Tyr
        275                 280                 285             
Ala Ser Trp Ile Asn Gly Ala Val Ile Lys Phe Asp Gly Gly Glu Glu
    290                 295                 300                 
Val Leu Ile Ser Gly Glu Phe Asn Asp Leu Arg Lys Val Thr Lys Glu
305                 310                 315                 320 
Gln Trp Asp Thr Ile Glu Glu Leu Ile Arg Lys Thr Lys Gly Ser
                325                 330                 335 


<210> 410
<211> 519
<212> PRT
<213> Homo sapiens

<400> 410
Met Ala Ala Pro Ser Arg Leu Leu Ile Arg Gly Gly Arg Val Val Asn
 1               5                  10                  15      
Asp Asp Phe Ser Glu Val Ala Asp Val Leu Val Glu Asp Gly Val Val
            20                  25                  30          
Arg Ala Leu Gly His Asp Leu Leu Pro Pro Gly Gly Ala Pro Ala Gly
        35                  40                  45              
Leu Arg Val Leu Asp Ala Ala Gly Lys Leu Val Leu Pro Gly Gly Ile
    50                  55                  60                  
Asp Thr His Thr His Met Gln Phe Pro Phe Met Gly Ser Arg Ser Ile
65                  70                  75                  80  
Asp Asp Phe His Gln Gly Thr Lys Ala Ala Leu Ser Gly Gly Thr Thr
                85                  90                  95      
Met Ile Ile Asp Phe Ala Ile Pro Gln Lys Gly Gly Ser Leu Ile Glu
            100                 105                 110         
Ala Phe Glu Thr Trp Arg Ser Trp Ala Asp Pro Lys Val Cys Cys Asp
        115                 120                 125             
Tyr Ser Leu His Val Ala Val Thr Trp Trp Ser Asp Gln Val Lys Glu
    130                 135                 140                 
Glu Met Lys Ile Leu Val Gln Asp Lys Gly Val Asn Ser Phe Lys Met
145                 150                 155                 160 
Phe Met Ala Tyr Lys Asp Leu Tyr Met Val Thr Asp Leu Glu Leu Tyr
                165                 170                 175     
Glu Ala Phe Ser Arg Cys Lys Glu Ile Gly Ala Ile Ala Gln Val His
            180                 185                 190         
Ala Glu Asn Gly Asp Leu Ile Ala Glu Gly Ala Lys Lys Met Leu Ala
        195                 200                 205             
Leu Gly Ile Thr Gly Pro Glu Gly His Glu Leu Cys Arg Pro Glu Ala
    210                 215                 220                 
Val Glu Ala Glu Ala Thr Leu Arg Ala Ile Thr Ile Ala Ser Ala Val
225                 230                 235                 240 
Asn Cys Pro Leu Tyr Ile Val His Val Met Ser Lys Ser Ala Ala Lys
                245                 250                 255     
Val Ile Ala Asp Ala Arg Arg Asp Gly Lys Val Val Tyr Gly Glu Pro
            260                 265                 270         
Ile Ala Ala Ser Leu Gly Thr Asp Gly Thr His Tyr Trp Asn Lys Glu
        275                 280                 285             
Trp His His Ala Ala His His Val Met Gly Pro Pro Leu Arg Pro Asp
    290                 295                 300                 
Pro Ser Thr Pro Asp Phe Leu Met Asn Leu Leu Ala Asn Asp Asp Leu
305                 310                 315                 320 
Thr Thr Thr Gly Thr Asp Asn Cys Thr Phe Asn Thr Cys Gln Lys Ala
                325                 330                 335     
Leu Gly Lys Asp Asp Phe Thr Lys Ile Pro Asn Gly Val Asn Gly Val
            340                 345                 350         
Glu Asp Arg Met Ser Val Ile Trp Glu Lys Gly Val His Ser Gly Lys
        355                 360                 365             
Met Asp Glu Asn Arg Phe Val Ala Val Thr Ser Thr Asn Ala Ala Lys
    370                 375                 380                 
Ile Phe Asn Leu Tyr Pro Arg Lys Gly Arg Ile Ala Val Gly Ser Asp
385                 390                 395                 400 
Ala Asp Ile Val Ile Trp Asp Pro Lys Gly Thr Arg Thr Ile Ser Ala
                405                 410                 415     
Lys Thr His His Gln Ala Val Asn Phe Asn Ile Phe Glu Gly Met Val
            420                 425                 430         
Cys His Gly Val Pro Leu Val Thr Ile Ser Arg Gly Lys Val Val Tyr
        435                 440                 445             
Glu Ala Gly Val Phe Ser Val Thr Ala Gly Asp Gly Lys Phe Ile Pro
    450                 455                 460                 
Arg Lys Pro Phe Ala Glu Tyr Ile Tyr Lys Arg Ile Lys Gln Arg Asp
465                 470                 475                 480 
Arg Thr Cys Thr Pro Thr Pro Val Glu Arg Ala Pro Tyr Lys Gly Glu
                485                 490                 495     
Val Ala Thr Leu Lys Ser Arg Val Thr Lys Glu Asp Ala Thr Ala Gly
            500                 505                 510         
Thr Arg Lys Gln Ala His Pro
        515                 


<210> 411
<211> 2080
<212> PRT
<213> Homo sapiens

<400> 411
Met Leu Arg Val Phe Ile Leu Tyr Ala Glu Asn Val His Thr Pro Asp
 1               5                  10                  15      
Thr Asp Ile Ser Asp Ala Tyr Cys Ser Ala Val Phe Ala Gly Val Lys
            20                  25                  30          
Lys Arg Thr Lys Val Ile Lys Asn Ser Val Asn Pro Val Trp Asn Glu
        35                  40                  45              
Gly Phe Glu Trp Asp Leu Lys Gly Ile Pro Leu Asp Gln Gly Ser Glu
    50                  55                  60                  
Leu His Val Val Val Lys Asp His Glu Thr Met Gly Arg Asn Arg Phe
65                  70                  75                  80  
Leu Gly Glu Ala Lys Val Pro Leu Arg Glu Val Leu Ala Thr Pro Ser
                85                  90                  95      
Leu Ser Ala Ser Phe Asn Ala Pro Leu Leu Asp Thr Lys Lys Gln Pro
            100                 105                 110         
Thr Gly Ala Ser Leu Val Leu Gln Val Ser Tyr Thr Pro Leu Pro Gly
        115                 120                 125             
Ala Val Pro Leu Phe Pro Pro Pro Thr Pro Leu Glu Pro Ser Pro Thr
    130                 135                 140                 
Leu Pro Asp Leu Asp Val Val Ala Asp Thr Gly Gly Glu Glu Asp Thr
145                 150                 155                 160 
Glu Asp Gln Gly Leu Thr Gly Asp Glu Ala Glu Pro Phe Leu Asp Gln
                165                 170                 175     
Ser Gly Gly Pro Gly Ala Pro Thr Thr Pro Arg Lys Leu Pro Ser Arg
            180                 185                 190         
Pro Pro Pro His Tyr Pro Gly Ile Lys Arg Lys Arg Ser Ala Pro Thr
        195                 200                 205             
Ser Arg Lys Leu Leu Ser Asp Lys Pro Gln Asp Phe Gln Ile Arg Val
    210                 215                 220                 
Gln Val Ile Glu Gly Arg Gln Leu Pro Gly Val Asn Ile Lys Pro Val
225                 230                 235                 240 
Val Lys Val Thr Ala Ala Gly Gln Thr Lys Arg Thr Arg Ile His Lys
                245                 250                 255     
Gly Asn Ser Pro Leu Phe Asn Glu Thr Leu Phe Phe Asn Leu Phe Asp
            260                 265                 270         
Ser Pro Gly Glu Leu Phe Asp Glu Pro Ile Phe Ile Thr Val Val Asp
        275                 280                 285             
Ser Arg Ser Leu Arg Thr Asp Ala Leu Leu Gly Glu Phe Arg Met Asp
    290                 295                 300                 
Val Gly Thr Ile Tyr Arg Glu Pro Arg His Ala Tyr Leu Arg Lys Trp
305                 310                 315                 320 
Leu Leu Leu Ser Asp Pro Asp Asp Phe Ser Ala Gly Ala Arg Gly Tyr
                325                 330                 335     
Leu Lys Thr Ser Leu Cys Val Leu Gly Pro Gly Asp Glu Ala Pro Leu
            340                 345                 350         
Glu Arg Lys Asp Pro Ser Glu Asp Lys Glu Asp Ile Glu Ser Asn Leu
        355                 360                 365             
Leu Arg Pro Thr Gly Val Ala Leu Arg Gly Ala His Phe Cys Leu Lys
    370                 375                 380                 
Val Phe Arg Ala Glu Asp Leu Pro Gln Met Asp Asp Ala Val Met Asp
385                 390                 395                 400 
Asn Val Lys Gln Ile Phe Gly Phe Glu Ser Asn Lys Lys Asn Leu Val
                405                 410                 415     
Asp Pro Phe Val Glu Val Ser Phe Ala Gly Lys Met Leu Cys Ser Lys
            420                 425                 430         
Ile Leu Glu Lys Thr Ala Asn Pro Gln Trp Asn Gln Asn Ile Thr Leu
        435                 440                 445             
Pro Ala Met Phe Pro Ser Met Cys Glu Lys Met Arg Ile Arg Ile Ile
    450                 455                 460                 
Asp Trp Asp Arg Leu Thr His Asn Asp Ile Val Ala Thr Thr Tyr Leu
465                 470                 475                 480 
Ser Met Ser Lys Ile Ser Ala Pro Gly Gly Glu Ile Glu Glu Glu Pro
                485                 490                 495     
Ala Gly Ala Val Lys Pro Ser Lys Ala Ser Asp Leu Asp Asp Tyr Leu
            500                 505                 510         
Gly Phe Leu Pro Thr Phe Gly Pro Cys Tyr Ile Asn Leu Tyr Gly Ser
        515                 520                 525             
Pro Arg Glu Phe Thr Gly Phe Pro Asp Pro Tyr Thr Glu Leu Asn Thr
    530                 535                 540                 
Gly Lys Gly Glu Gly Val Ala Tyr Arg Gly Arg Leu Leu Leu Ser Leu
545                 550                 555                 560 
Glu Thr Lys Leu Val Glu His Ser Glu Gln Lys Val Glu Asp Leu Pro
                565                 570                 575     
Ala Asp Asp Ile Leu Arg Val Glu Lys Tyr Leu Arg Arg Arg Lys Tyr
            580                 585                 590         
Ser Leu Phe Ala Ala Phe Tyr Ser Ala Thr Met Leu Gln Asp Val Asp
        595                 600                 605             
Asp Ala Ile Gln Phe Glu Val Ser Ile Gly Asn Tyr Gly Asn Lys Phe
    610                 615                 620                 
Asp Met Thr Cys Leu Pro Leu Ala Ser Thr Thr Gln Tyr Ser Arg Ala
625                 630                 635                 640 
Val Phe Asp Gly Cys His Tyr Tyr Tyr Leu Pro Trp Gly Asn Val Lys
                645                 650                 655     
Pro Val Val Val Leu Ser Ser Tyr Trp Glu Asp Ile Ser His Arg Ile
            660                 665                 670         
Glu Thr Gln Asn Gln Leu Leu Gly Ile Ala Asp Arg Leu Glu Ala Gly
        675                 680                 685             
Leu Glu Gln Val His Leu Ala Leu Lys Ala Gln Cys Ser Thr Glu Asp
    690                 695                 700                 
Val Asp Ser Leu Val Ala Gln Leu Thr Asp Glu Leu Ile Ala Gly Cys
705                 710                 715                 720 
Ser Gln Pro Leu Gly Asp Ile His Glu Thr Pro Ser Ala Thr His Leu
                725                 730                 735     
Asp Gln Tyr Leu Tyr Gln Leu Arg Thr His His Leu Ser Gln Ile Thr
            740                 745                 750         
Glu Ala Ala Leu Ala Leu Lys Leu Gly His Ser Glu Leu Pro Ala Ala
        755                 760                 765             
Leu Glu Gln Ala Glu Asp Trp Leu Leu Arg Leu Arg Ala Leu Ala Glu
    770                 775                 780                 
Glu Pro Gln Asn Ser Leu Pro Asp Ile Val Ile Trp Met Leu Gln Gly
785                 790                 795                 800 
Asp Lys Arg Val Ala Tyr Gln Arg Val Pro Ala His Gln Val Leu Phe
                805                 810                 815     
Ser Arg Arg Gly Ala Asn Tyr Cys Gly Lys Asn Cys Gly Lys Leu Gln
            820                 825                 830         
Thr Ile Phe Leu Lys Tyr Pro Met Glu Lys Val Pro Gly Ala Arg Met
        835                 840                 845             
Pro Val Gln Ile Arg Val Lys Leu Trp Phe Gly Leu Ser Val Asp Glu
    850                 855                 860                 
Lys Glu Phe Asn Gln Phe Ala Glu Gly Lys Leu Ser Val Phe Ala Glu
865                 870                 875                 880 
Thr Tyr Glu Asn Glu Thr Lys Leu Ala Leu Val Gly Asn Trp Gly Thr
                885                 890                 895     
Thr Gly Leu Thr Tyr Pro Lys Phe Ser Asp Val Thr Gly Lys Ile Lys
            900                 905                 910         
Leu Pro Lys Asp Ser Phe Arg Pro Ser Ala Gly Trp Thr Trp Ala Gly
        915                 920                 925             
Asp Trp Phe Val Cys Pro Glu Lys Thr Leu Leu His Asp Met Asp Ala
    930                 935                 940                 
Gly His Leu Ser Phe Val Glu Glu Val Phe Glu Asn Gln Thr Arg Leu
945                 950                 955                 960 
Pro Gly Gly Gln Trp Ile Tyr Met Ser Asp Asn Tyr Thr Asp Val Asn
                965                 970                 975     
Gly Glu Lys Val Leu Pro Lys Asp Asp Ile Glu Cys Pro Leu Gly Trp
            980                 985                 990         
Lys Trp Glu Asp Glu Glu Trp Ser Thr Asp Leu Asn Arg Ala Val Asp
        995                 1000                1005            
Glu Gln Gly Trp Glu Tyr Ser Ile Thr Ile Pro Pro Glu Arg Lys Pro
    1010                1015                1020                
Lys His Trp Val Pro Ala Glu Lys Met Tyr Tyr Thr His Arg Arg Arg
1025                1030                1035                1040
Arg Trp Val Arg Leu Arg Arg Arg Asp Leu Ser Gln Met Glu Ala Leu
                1045                1050                1055    
Lys Arg His Arg Gln Ala Glu Ala Glu Gly Glu Gly Trp Glu Tyr Ala
            1060                1065                1070        
Ser Leu Phe Gly Trp Lys Phe His Leu Glu Tyr Arg Lys Thr Asp Ala
        1075                1080                1085            
Phe Arg Arg Arg Arg Trp Arg Arg Arg Met Glu Pro Leu Glu Lys Thr
    1090                1095                1100                
Gly Pro Ala Ala Val Phe Ala Leu Glu Gly Ala Leu Gly Gly Val Met
1105                1110                1115                1120
Asp Asp Lys Ser Glu Asp Ser Met Ser Val Ser Thr Leu Ser Phe Gly
                1125                1130                1135    
Val Asn Arg Pro Thr Ile Ser Cys Ile Phe Asp Tyr Gly Asn Arg Tyr
            1140                1145                1150        
His Leu Arg Cys Tyr Met Tyr Gln Ala Arg Asp Leu Ala Ala Met Asp
        1155                1160                1165            
Lys Asp Ser Phe Ser Asp Pro Tyr Ala Ile Val Ser Phe Leu His Gln
    1170                1175                1180                
Ser Gln Lys Thr Val Val Val Lys Asn Thr Leu Asn Pro Thr Trp Asp
1185                1190                1195                1200
Gln Thr Leu Ile Phe Tyr Glu Ile Glu Ile Phe Gly Glu Pro Ala Thr
                1205                1210                1215    
Val Ala Glu Gln Pro Pro Ser Ile Val Val Glu Leu Tyr Asp His Asp
            1220                1225                1230        
Thr Tyr Gly Ala Asp Glu Phe Met Gly Arg Cys Ile Cys Gln Pro Ser
        1235                1240                1245            
Leu Glu Arg Met Pro Arg Leu Ala Trp Phe Pro Leu Thr Arg Gly Ser
    1250                1255                1260                
Gln Pro Ser Gly Glu Leu Leu Ala Ser Phe Glu Leu Ile Gln Arg Glu
1265                1270                1275                1280
Lys Pro Ala Ile His His Ile Pro Gly Phe Glu Val Gln Glu Thr Ser
                1285                1290                1295    
Arg Ile Leu Asp Glu Ser Glu Asp Thr Asp Leu Pro Tyr Pro Pro Pro
            1300                1305                1310        
Gln Arg Glu Ala Asn Ile Tyr Met Val Pro Gln Asn Ile Lys Pro Ala
        1315                1320                1325            
Leu Gln Arg Thr Ala Ile Glu Ile Leu Ala Trp Gly Leu Arg Asn Met
    1330                1335                1340                
Lys Ser Tyr Gln Leu Ala Asn Ile Ser Ser Pro Ser Leu Val Val Glu
1345                1350                1355                1360
Cys Gly Gly Gln Thr Val Gln Ser Cys Val Ile Arg Asn Leu Arg Lys
                1365                1370                1375    
Asn Pro Asn Phe Asp Ile Cys Thr Leu Phe Met Glu Val Met Leu Pro
            1380                1385                1390        
Arg Glu Glu Leu Tyr Cys Pro Pro Ile Thr Val Lys Val Ile Asp Asn
        1395                1400                1405            
Arg Gln Phe Gly Arg Arg Pro Val Val Gly Gln Cys Thr Ile Arg Ser
    1410                1415                1420                
Leu Glu Ser Phe Leu Cys Asp Pro Tyr Ser Ala Glu Ser Pro Ser Pro
1425                1430                1435                1440
Gln Gly Gly Pro Asp Asp Val Ser Leu Leu Ser Pro Gly Glu Asp Val
                1445                1450                1455    
Leu Ile Asp Ile Asp Asp Lys Glu Pro Leu Ile Pro Ile Gln Glu Glu
            1460                1465                1470        
Glu Phe Ile Asp Trp Trp Ser Lys Phe Phe Ala Ser Ile Gly Glu Arg
        1475                1480                1485            
Glu Lys Cys Gly Ser Tyr Leu Glu Lys Asp Phe Asp Thr Leu Lys Val
    1490                1495                1500                
Tyr Asp Thr Gln Leu Glu Asn Val Glu Ala Phe Glu Gly Leu Ser Asp
1505                1510                1515                1520
Phe Cys Asn Thr Phe Lys Leu Tyr Arg Gly Lys Thr Gln Glu Glu Thr
                1525                1530                1535    
Glu Asp Pro Ser Val Ile Gly Glu Phe Lys Gly Leu Phe Lys Ile Tyr
            1540                1545                1550        
Pro Leu Pro Glu Asp Pro Ala Ile Pro Met Pro Pro Arg Gln Phe His
        1555                1560                1565            
Gln Leu Ala Ala Gln Gly Pro Gln Glu Cys Leu Val Arg Ile Tyr Ile
    1570                1575                1580                
Val Arg Ala Phe Gly Leu Gln Pro Lys Asp Pro Asn Gly Lys Cys Asp
1585                1590                1595                1600
Pro Tyr Ile Lys Ile Ser Ile Gly Lys Lys Ser Val Ser Asp Gln Asp
                1605                1610                1615    
Asn Tyr Ile Pro Cys Thr Leu Glu Pro Val Phe Gly Lys Met Phe Glu
            1620                1625                1630        
Leu Thr Cys Thr Leu Pro Leu Glu Lys Asp Leu Lys Ile Thr Leu Tyr
        1635                1640                1645            
Asp Tyr Asp Leu Leu Ser Lys Asp Glu Lys Ile Gly Glu Thr Val Val
    1650                1655                1660                
Asp Leu Glu Asn Arg Leu Leu Ser Lys Phe Gly Ala Arg Cys Gly Leu
1665                1670                1675                1680
Pro Gln Thr Tyr Cys Val Ser Gly Pro Asn Gln Trp Arg Asp Gln Leu
                1685                1690                1695    
Arg Pro Ser Gln Leu Leu His Leu Phe Cys Gln Gln His Arg Val Lys
            1700                1705                1710        
Ala Pro Val Tyr Arg Thr Asp Arg Val Met Phe Gln Asp Lys Glu Tyr
        1715                1720                1725            
Ser Ile Glu Glu Ile Glu Ala Gly Arg Ile Pro Asn Pro His Leu Gly
    1730                1735                1740                
Pro Val Glu Glu Arg Leu Ala Leu His Val Leu Gln Gln Gln Gly Leu
1745                1750                1755                1760
Val Pro Glu His Val Glu Ser Arg Pro Leu Tyr Ser Pro Leu Gln Pro
                1765                1770                1775    
Asp Ile Glu Gln Gly Lys Leu Gln Met Trp Val Asp Leu Phe Pro Lys
            1780                1785                1790        
Ala Leu Gly Arg Pro Gly Pro Pro Phe Asn Ile Thr Pro Arg Arg Ala
        1795                1800                1805            
Arg Arg Phe Phe Leu Arg Cys Ile Ile Trp Asn Thr Arg Asp Val Ile
    1810                1815                1820                
Leu Asp Asp Leu Ser Leu Thr Gly Glu Lys Met Ser Asp Ile Tyr Val
1825                1830                1835                1840
Lys Gly Trp Met Ile Gly Phe Glu Glu His Lys Gln Lys Thr Asp Val
                1845                1850                1855    
His Tyr Arg Ser Leu Gly Gly Glu Gly Asn Phe Asn Trp Arg Phe Ile
            1860                1865                1870        
Phe Pro Phe Asp Tyr Leu Pro Ala Glu Gln Val Cys Thr Ile Ala Lys
        1875                1880                1885            
Lys Asp Ala Phe Trp Arg Leu Asp Lys Thr Glu Ser Lys Ile Pro Ala
    1890                1895                1900                
Arg Val Val Phe Gln Ile Trp Asp Asn Asp Lys Phe Ser Phe Asp Asp
1905                1910                1915                1920
Phe Leu Gly Ser Leu Gln Leu Asp Leu Asn Arg Met Pro Lys Pro Ala
                1925                1930                1935    
Lys Thr Ala Lys Lys Cys Ser Leu Asp Gln Leu Asp Asp Ala Phe His
            1940                1945                1950        
Pro Glu Trp Phe Val Ser Leu Phe Glu Gln Lys Thr Val Lys Gly Trp
        1955                1960                1965            
Trp Pro Cys Val Ala Glu Glu Gly Glu Lys Lys Ile Leu Ala Gly Lys
    1970                1975                1980                
Leu Glu Met Thr Leu Glu Ile Val Ala Glu Ser Glu His Glu Glu Arg
1985                1990                1995                2000
Pro Ala Gly Gln Gly Arg Asp Glu Pro Asn Met Asn Pro Lys Leu Glu
                2005                2010                2015    
Asp Pro Arg Arg Pro Asp Thr Ser Phe Leu Trp Phe Thr Ser Pro Tyr
            2020                2025                2030        
Lys Thr Met Lys Phe Ile Leu Trp Arg Arg Phe Arg Trp Ala Ile Ile
        2035                2040                2045            
Leu Phe Ile Ile Leu Phe Ile Leu Leu Leu Phe Leu Ala Ile Phe Ile
    2050                2055                2060                
Tyr Ala Phe Pro Asn Tyr Ala Ala Met Lys Leu Val Lys Pro Phe Ser
2065                2070                2075                2080


<210> 412
<211> 770
<212> PRT
<213> Homo sapiens

<400> 412
Met Arg Gly Val Trp Pro Pro Pro Val Ser Ala Leu Leu Ser Ala Leu
 1               5                  10                  15      
Gly Met Ser Thr Tyr Lys Arg Ala Thr Leu Asp Glu Glu Asp Leu Val
            20                  25                  30          
Asp Ser Leu Ser Glu Gly Asp Ala Tyr Pro Asn Gly Leu Gln Val Asn
        35                  40                  45              
Phe His Ser Pro Arg Ser Gly Gln Arg Cys Trp Ala Ala Arg Thr Gln
    50                  55                  60                  
Val Glu Lys Arg Leu Val Val Leu Val Val Leu Leu Ala Ala Gly Leu
65                  70                  75                  80  
Val Ala Cys Leu Ala Ala Leu Gly Ile Gln Tyr Gln Thr Arg Ser Pro
                85                  90                  95      
Ser Val Cys Leu Ser Glu Ala Cys Val Ser Val Thr Ser Ser Ile Leu
            100                 105                 110         
Ser Ser Met Asp Pro Thr Val Asp Pro Cys His Asp Phe Phe Ser Tyr
        115                 120                 125             
Ala Cys Gly Gly Trp Ile Lys Ala Asn Pro Val Pro Asp Gly His Ser
    130                 135                 140                 
Arg Trp Gly Thr Phe Ser Asn Leu Trp Glu His Asn Gln Ala Ile Ile
145                 150                 155                 160 
Lys His Leu Leu Glu Asn Ser Thr Ala Ser Val Ser Glu Ala Glu Arg
                165                 170                 175     
Lys Ala Gln Val Tyr Tyr Arg Ala Cys Met Asn Glu Thr Arg Ile Glu
            180                 185                 190         
Glu Leu Arg Ala Lys Pro Leu Met Glu Leu Ile Glu Arg Leu Gly Gly
        195                 200                 205             
Trp Asn Ile Thr Gly Pro Trp Ala Lys Asp Asn Phe Gln Asp Thr Leu
    210                 215                 220                 
Gln Val Val Thr Ala His Tyr Arg Thr Ser Pro Phe Phe Ser Val Tyr
225                 230                 235                 240 
Val Ser Ala Asp Ser Lys Asn Ser Asn Ser Asn Val Ile Gln Val Asp
                245                 250                 255     
Gln Ser Gly Leu Gly Leu Pro Ser Arg Asp Tyr Tyr Leu Asn Lys Thr
            260                 265                 270         
Glu Asn Glu Lys Val Leu Thr Gly Tyr Leu Asn Tyr Met Val Gln Leu
        275                 280                 285             
Gly Lys Leu Leu Gly Gly Gly Asp Glu Glu Ala Ile Arg Pro Gln Met
    290                 295                 300                 
Gln Gln Ile Leu Asp Phe Glu Thr Ala Leu Ala Asn Ile Thr Ile Pro
305                 310                 315                 320 
Gln Glu Lys Arg Arg Asp Glu Glu Leu Ile Tyr His Lys Val Thr Ala
                325                 330                 335     
Ala Glu Leu Gln Thr Leu Ala Pro Ala Ile Asn Trp Leu Pro Phe Leu
            340                 345                 350         
Asn Thr Ile Phe Tyr Pro Val Glu Ile Asn Glu Ser Glu Pro Ile Val
        355                 360                 365             
Val Tyr Asp Lys Glu Tyr Leu Glu Gln Ile Ser Thr Leu Ile Asn Thr
    370                 375                 380                 
Thr Asp Arg Cys Leu Leu Asn Asn Tyr Met Ile Trp Asn Leu Val Arg
385                 390                 395                 400 
Lys Thr Ser Ser Phe Leu Asp Gln Arg Phe Gln Asp Ala Asp Glu Lys
                405                 410                 415     
Phe Met Glu Val Met Tyr Gly Thr Lys Lys Thr Cys Leu Pro Arg Trp
            420                 425                 430         
Lys Phe Cys Val Ser Asp Thr Glu Asn Asn Leu Gly Phe Ala Leu Gly
        435                 440                 445             
Pro Met Phe Val Lys Ala Thr Phe Ala Glu Asp Ser Lys Ser Ile Ala
    450                 455                 460                 
Thr Glu Ile Ile Leu Glu Ile Lys Lys Ala Phe Glu Glu Ser Leu Ser
465                 470                 475                 480 
Thr Leu Lys Trp Met Asp Glu Glu Thr Arg Lys Ser Ala Lys Glu Lys
                485                 490                 495     
Ala Asp Ala Ile Tyr Asn Met Ile Gly Tyr Pro Asn Phe Ile Met Asp
            500                 505                 510         
Pro Lys Glu Leu Asp Lys Val Phe Asn Asp Tyr Thr Ala Val Pro Asp
        515                 520                 525             
Leu Tyr Phe Glu Asn Ala Met Arg Phe Phe Asn Phe Ser Trp Arg Val
    530                 535                 540                 
Thr Ala Asp Gln Leu Arg Lys Ala Pro Asn Arg Asp Gln Trp Ser Met
545                 550                 555                 560 
Thr Pro Pro Met Val Asn Ala Tyr Tyr Ser Pro Thr Lys Asn Glu Ile
                565                 570                 575     
Val Phe Pro Ala Gly Ile Leu Gln Ala Pro Phe Tyr Thr Arg Ser Ser
            580                 585                 590         
Pro Lys Ala Leu Asn Phe Gly Gly Ile Gly Val Val Val Gly His Glu
        595                 600                 605             
Leu Thr His Ala Phe Asp Asp Gln Gly Arg Glu Tyr Asp Lys Asp Gly
    610                 615                 620                 
Asn Leu Arg Pro Trp Trp Lys Asn Ser Ser Val Glu Ala Phe Lys Arg
625                 630                 635                 640 
Gln Thr Glu Cys Met Val Glu Gln Tyr Ser Asn Tyr Ser Val Asn Gly
                645                 650                 655     
Glu Pro Val Asn Gly Arg His Thr Leu Gly Glu Asn Ile Ala Asp Asn
            660                 665                 670         
Gly Gly Leu Lys Ala Ala Tyr Arg Ala Tyr Gln Asn Trp Val Lys Lys
        675                 680                 685             
Asn Gly Ala Glu His Ser Leu Pro Thr Leu Gly Leu Thr Asn Asn Gln
    690                 695                 700                 
Leu Phe Phe Leu Gly Phe Ala Gln Val Trp Cys Ser Val Arg Thr Pro
705                 710                 715                 720 
Glu Ser Ser His Glu Gly Leu Ile Thr Asp Pro His Ser Pro Ser Arg
                725                 730                 735     
Phe Arg Val Ile Gly Ser Leu Ser Asn Ser Lys Glu Phe Ser Glu His
            740                 745                 750         
Phe Arg Cys Pro Pro Gly Ser Pro Met Asn Pro Pro His Lys Cys Glu
        755                 760                 765             
Val Trp
    770 


<210> 413
<211> 328
<212> PRT
<213> Homo sapiens

<400> 413
Met Ala Ala Gly Ile Val Ala Ser Arg Arg Leu Arg Asp Leu Leu Thr
 1               5                  10                  15      
Arg Arg Leu Thr Gly Ser Asn Tyr Pro Gly Leu Ser Ile Ser Leu Arg
            20                  25                  30          
Leu Thr Gly Ser Ser Ala Gln Glu Glu Ala Ser Gly Val Ala Leu Gly
        35                  40                  45              
Glu Ala Pro Asp His Ser Tyr Glu Ser Leu Arg Val Thr Ser Ala Gln
    50                  55                  60                  
Lys His Val Leu His Val Gln Leu Asn Arg Pro Asn Lys Arg Asn Ala
65                  70                  75                  80  
Met Asn Lys Val Phe Trp Arg Glu Met Val Glu Cys Phe Asn Lys Ile
                85                  90                  95      
Ser Arg Asp Ala Asp Cys Arg Ala Val Val Ile Ser Gly Ala Gly Lys
            100                 105                 110         
Met Phe Thr Ala Gly Ile Asp Leu Met Asp Met Ala Ser Asp Ile Leu
        115                 120                 125             
Gln Pro Lys Gly Asp Asp Val Ala Arg Ile Ser Trp Tyr Leu Arg Asp
    130                 135                 140                 
Ile Ile Thr Arg Tyr Gln Glu Thr Phe Asn Val Ile Glu Arg Cys Pro
145                 150                 155                 160 
Lys Pro Val Ile Ala Ala Val His Gly Gly Cys Ile Gly Gly Gly Val
                165                 170                 175     
Asp Leu Val Thr Ala Cys Asp Ile Arg Tyr Cys Ala Gln Asp Ala Phe
            180                 185                 190         
Phe Gln Val Lys Glu Val Asp Val Gly Leu Ala Ala Asp Val Gly Thr
        195                 200                 205             
Leu Glu Arg Leu Pro Lys Val Ile Gly Asn Gln Ser Leu Val Asn Glu
    210                 215                 220                 
Leu Ala Phe Thr Ala His Lys Met Met Ala Asp Glu Ala Leu Asp Ser
225                 230                 235                 240 
Gly Leu Val Ser Arg Val Phe Pro Asp Lys Glu Val Met Leu Asp Ala
                245                 250                 255     
Ala Leu Pro Leu Ala Pro Glu Ile Ser Ser Lys Thr Thr Val Leu Val
            260                 265                 270         
Gln Ser Thr Lys Val Asn Leu Leu Tyr Ser Arg Asp His Ser Val Ala
        275                 280                 285             
Glu Ser Leu Asn Tyr Val Ala Ser Trp Asn Met Ser Met Leu Gln Thr
    290                 295                 300                 
Gln Asp Leu Val Lys Ser Val Gln Pro Thr Thr Glu Asn Lys Glu Leu
305                 310                 315                 320 
Lys Thr Val Thr Phe Ser Lys Leu
                325             


<210> 414
<211> 463
<212> PRT
<213> Homo sapiens

<400> 414
Met Gly Lys Glu Lys Thr His Ile Asn Ile Val Val Ile Gly His Val
 1               5                  10                  15      
Asp Ser Gly Lys Ser Thr Thr Thr Gly His Leu Ile Tyr Lys Cys Gly
            20                  25                  30          
Gly Ile Asp Lys Arg Thr Ile Glu Lys Phe Glu Lys Glu Ala Ala Glu
        35                  40                  45              
Met Gly Lys Gly Ser Phe Lys Tyr Ala Trp Val Leu Asp Lys Leu Lys
    50                  55                  60                  
Ala Glu Arg Glu Arg Gly Ile Thr Ile Asp Ile Ser Leu Trp Lys Phe
65                  70                  75                  80  
Glu Thr Thr Lys Tyr Tyr Ile Thr Ile Ile Asp Ala Pro Gly His Arg
                85                  90                  95      
Asp Phe Ile Lys Asn Met Ile Thr Gly Thr Ser Gln Ala Asp Cys Ala
            100                 105                 110         
Val Leu Ile Val Ala Ala Gly Val Gly Glu Phe Glu Ala Gly Ile Ser
        115                 120                 125             
Lys Asn Gly Gln Thr Arg Glu His Ala Leu Leu Ala Tyr Thr Leu Gly
    130                 135                 140                 
Val Lys Gln Leu Ile Val Gly Val Asn Lys Met Asp Ser Thr Glu Pro
145                 150                 155                 160 
Ala Tyr Ser Glu Lys Arg Tyr Asp Glu Ile Val Lys Glu Val Ser Ala
                165                 170                 175     
Tyr Ile Lys Lys Ile Gly Tyr Asn Pro Ala Thr Val Pro Phe Val Pro
            180                 185                 190         
Ile Ser Gly Trp His Gly Asp Asn Met Leu Glu Pro Ser Pro Asn Met
        195                 200                 205             
Pro Trp Phe Lys Gly Trp Lys Val Glu Arg Lys Glu Gly Asn Ala Ser
    210                 215                 220                 
Gly Val Ser Leu Leu Glu Ala Leu Asp Thr Ile Leu Pro Pro Thr Arg
225                 230                 235                 240 
Pro Thr Asp Lys Pro Leu Arg Leu Pro Leu Gln Asp Val Tyr Lys Ile
                245                 250                 255     
Gly Gly Ile Gly Thr Val Pro Val Gly Arg Val Glu Thr Gly Ile Leu
            260                 265                 270         
Arg Pro Gly Met Val Val Thr Phe Ala Pro Val Asn Ile Thr Thr Glu
        275                 280                 285             
Val Lys Ser Val Glu Met His His Glu Ala Leu Ser Glu Ala Leu Pro
    290                 295                 300                 
Gly Asp Asn Val Gly Phe Asn Val Lys Asn Val Ser Val Lys Asp Ile
305                 310                 315                 320 
Arg Arg Gly Asn Val Cys Gly Asp Ser Lys Ser Asp Pro Pro Gln Glu
                325                 330                 335     
Ala Ala Gln Phe Thr Ser Gln Val Ile Ile Leu Asn His Pro Gly Gln
            340                 345                 350         
Ile Ser Ala Gly Tyr Ser Pro Val Ile Asp Cys His Thr Ala His Ile
        355                 360                 365             
Ala Cys Lys Phe Ala Glu Leu Lys Glu Lys Ile Asp Arg Arg Ser Gly
    370                 375                 380                 
Lys Lys Leu Glu Asp Asn Pro Lys Ser Leu Lys Ser Gly Asp Ala Ala
385                 390                 395                 400 
Ile Val Glu Met Val Pro Gly Lys Pro Met Cys Val Glu Ser Phe Ser
                405                 410                 415     
Gln Tyr Pro Pro Leu Gly Arg Phe Ala Val Arg Asp Met Arg Gln Thr
            420                 425                 430         
Val Ala Val Gly Val Ile Lys Asn Val Glu Lys Lys Ser Gly Gly Ala
        435                 440                 445             
Gly Lys Val Thr Lys Ser Ala Gln Lys Ala Gln Lys Ala Gly Lys
    450                 455                 460             


<210> 415
<211> 472
<212> PRT
<213> Homo sapiens

<400> 415
Met Ala Gly Gly Glu Ala Gly Val Thr Leu Gly Gln Pro His Leu Ser
 1               5                  10                  15      
Arg Gln Asp Leu Thr Thr Leu Asp Val Thr Lys Leu Thr Pro Leu Ser
            20                  25                  30          
His Glu Val Ile Ser Arg Gln Ala Thr Ile Asn Ile Gly Thr Ile Gly
        35                  40                  45              
His Val Ala His Gly Lys Ser Thr Val Val Lys Ala Ile Ser Gly Val
    50                  55                  60                  
His Thr Val Arg Phe Lys Asn Glu Leu Glu Arg Asn Ile Thr Ile Lys
65                  70                  75                  80  
Leu Gly Tyr Ala Asn Ala Lys Ile Tyr Lys Leu Asp Asp Pro Ser Cys
                85                  90                  95      
Pro Arg Pro Glu Cys Tyr Arg Ser Cys Gly Ser Ser Thr Pro Asp Glu
            100                 105                 110         
Phe Pro Thr Asp Ile Pro Gly Thr Lys Gly Asn Phe Lys Leu Val Arg
        115                 120                 125             
His Val Ser Phe Val Asp Cys Pro Gly His Asp Ile Leu Met Ala Thr
    130                 135                 140                 
Met Leu Asn Gly Ala Ala Val Met Asp Ala Ala Leu Leu Leu Ile Ala
145                 150                 155                 160 
Gly Asn Glu Ser Cys Pro Gln Pro Gln Thr Ser Glu His Leu Ala Ala
                165                 170                 175     
Ile Glu Ile Met Lys Leu Lys His Ile Leu Ile Leu Gln Asn Lys Ile
            180                 185                 190         
Asp Leu Val Lys Glu Ser Gln Ala Lys Glu Gln Tyr Glu Gln Ile Leu
        195                 200                 205             
Ala Phe Val Gln Gly Thr Val Ala Glu Gly Ala Pro Ile Ile Pro Ile
    210                 215                 220                 
Ser Ala Gln Leu Lys Tyr Asn Ile Glu Val Val Cys Glu Tyr Ile Val
225                 230                 235                 240 
Lys Lys Ile Pro Val Pro Pro Arg Asp Phe Thr Ser Glu Pro Arg Leu
                245                 250                 255     
Ile Val Ile Arg Ser Phe Asp Val Asn Lys Pro Gly Cys Glu Val Asp
            260                 265                 270         
Asp Leu Lys Gly Gly Val Ala Gly Gly Ser Ile Leu Lys Gly Val Leu
        275                 280                 285             
Lys Val Gly Gln Glu Ile Glu Val Arg Pro Gly Ile Val Ser Lys Asp
    290                 295                 300                 
Ser Glu Gly Lys Leu Met Cys Lys Pro Ile Phe Ser Lys Ile Val Ser
305                 310                 315                 320 
Leu Phe Ala Glu His Asn Asp Leu Gln Tyr Ala Ala Pro Gly Gly Leu
                325                 330                 335     
Ile Gly Val Gly Thr Lys Ile Asp Pro Thr Leu Cys Arg Ala Asp Arg
            340                 345                 350         
Met Val Gly Gln Val Leu Gly Ala Val Gly Ala Leu Pro Glu Ile Phe
        355                 360                 365             
Thr Glu Leu Glu Ile Ser Tyr Phe Leu Leu Arg Arg Leu Leu Gly Val
    370                 375                 380                 
Arg Thr Glu Gly Asp Lys Lys Ala Ala Lys Val Gln Lys Leu Ser Lys
385                 390                 395                 400 
Asn Glu Val Leu Met Val Asn Ile Gly Ser Leu Ser Thr Gly Gly Arg
                405                 410                 415     
Val Ser Ala Val Lys Ala Asp Leu Gly Lys Ile Val Leu Thr Asn Pro
            420                 425                 430         
Val Cys Thr Glu Val Gly Glu Lys Ile Ala Leu Ser Arg Arg Val Glu
        435                 440                 445             
Lys His Trp Arg Leu Ile Gly Trp Gly Gln Ile Arg Arg Gly Val Thr
    450                 455                 460                 
Ile Lys Pro Thr Val Asp Asp Asp
465                 470         


<210> 416
<211> 100
<212> PRT
<213> Homo sapiens

<400> 416
Met Ser Thr Ser Thr Ser Cys Pro Ile Pro Gly Gly Arg Asp Gln Leu
 1               5                  10                  15      
Pro Asp Cys Tyr Ser Thr Thr Pro Gly Gly Thr Leu Tyr Ala Thr Thr
            20                  25                  30          
Pro Gly Gly Thr Arg Ile Ile Tyr Asp Arg Lys Phe Leu Leu Glu Cys
        35                  40                  45              
Lys Asn Ser Pro Ile Ala Arg Thr Pro Pro Cys Cys Leu Pro Gln Ile
    50                  55                  60                  
Pro Gly Val Thr Thr Pro Pro Thr Ala Pro Leu Ser Lys Leu Glu Glu
65                  70                  75                  80  
Leu Lys Glu Gln Glu Thr Glu Glu Glu Ile Pro Asp Asp Ala Gln Phe
                85                  90                  95      
Glu Met Asp Ile
            100 


<210> 417
<211> 333
<212> PRT
<213> Homo sapiens

<400> 417
Met Phe Arg Ala Ala Ala Pro Gly Gln Leu Arg Arg Ala Ala Ser Leu
 1               5                  10                  15      
Leu Arg Phe Gln Ser Thr Leu Val Ile Ala Glu His Ala Asn Asp Ser
            20                  25                  30          
Leu Ala Pro Ile Thr Leu Asn Thr Ile Thr Ala Ala Thr Arg Leu Gly
        35                  40                  45              
Gly Glu Val Ser Cys Leu Val Ala Gly Thr Lys Cys Asp Lys Val Ala
    50                  55                  60                  
Gln Asp Leu Cys Lys Val Ala Gly Ile Ala Lys Val Leu Val Ala Gln
65                  70                  75                  80  
His Asp Val Tyr Lys Gly Leu Leu Pro Glu Glu Leu Thr Pro Leu Ile
                85                  90                  95      
Leu Ala Thr Gln Lys Gln Phe Asn Tyr Thr His Ile Cys Ala Gly Ala
            100                 105                 110         
Ser Ala Phe Gly Lys Asn Leu Leu Pro Arg Val Ala Ala Lys Leu Glu
        115                 120                 125             
Val Ala Pro Ile Ser Asp Ile Ile Ala Ile Lys Ser Pro Asp Thr Phe
    130                 135                 140                 
Val Arg Thr Ile Tyr Ala Gly Asn Ala Leu Cys Thr Val Lys Cys Asp
145                 150                 155                 160 
Glu Lys Val Lys Val Phe Ser Val Arg Gly Thr Ser Phe Asp Ala Ala
                165                 170                 175     
Ala Thr Ser Gly Gly Ser Ala Ser Ser Glu Lys Ala Ser Ser Thr Ser
            180                 185                 190         
Pro Val Glu Ile Ser Glu Trp Leu Asp Gln Lys Leu Thr Lys Ser Asp
        195                 200                 205             
Arg Pro Glu Leu Thr Gly Ala Lys Val Val Val Ser Gly Gly Arg Gly
    210                 215                 220                 
Leu Lys Ser Gly Glu Asn Phe Lys Leu Leu Tyr Asp Leu Ala Asp Gln
225                 230                 235                 240 
Leu His Ala Ala Val Gly Ala Ser Arg Ala Ala Val Asp Ala Gly Phe
                245                 250                 255     
Val Pro Asn Asp Met Gln Val Gly Gln Thr Gly Lys Ile Val Ala Pro
            260                 265                 270         
Glu Leu Tyr Ile Ala Val Gly Ile Ser Gly Ala Ile Gln His Leu Ala
        275                 280                 285             
Gly Met Lys Asp Ser Lys Thr Ile Val Ala Ile Asn Lys Asp Pro Glu
    290                 295                 300                 
Ala Pro Ile Phe Gln Val Ala Asp Tyr Gly Ile Val Ala Asp Leu Phe
305                 310                 315                 320 
Lys Val Val Pro Glu Met Thr Glu Ile Leu Lys Lys Lys
                325                 330             


<210> 418
<211> 255
<212> PRT
<213> Homo sapiens

<400> 418
Met Ala Glu Leu Arg Val Leu Val Ala Val Lys Arg Val Ile Asp Tyr
 1               5                  10                  15      
Ala Val Lys Ile Arg Val Lys Pro Asp Arg Thr Gly Val Val Thr Asp
            20                  25                  30          
Gly Val Lys His Ser Met Asn Pro Phe Cys Glu Ile Ala Val Glu Glu
        35                  40                  45              
Ala Val Arg Leu Lys Glu Lys Lys Leu Val Lys Glu Val Ile Ala Val
    50                  55                  60                  
Ser Cys Gly Pro Ala Gln Cys Gln Glu Thr Ile Arg Thr Ala Leu Ala
65                  70                  75                  80  
Met Gly Ala Asp Arg Gly Ile His Val Glu Val Pro Pro Ala Glu Ala
                85                  90                  95      
Glu Arg Leu Gly Pro Leu Gln Val Ala Arg Val Leu Ala Lys Leu Ala
            100                 105                 110         
Glu Lys Glu Lys Val Asp Leu Val Leu Leu Gly Lys Gln Ala Ile Asp
        115                 120                 125             
Asp Asp Cys Asn Gln Thr Gly Gln Met Thr Ala Gly Phe Leu Asp Trp
    130                 135                 140                 
Pro Gln Gly Thr Phe Ala Ser Gln Val Thr Leu Glu Gly Asp Lys Leu
145                 150                 155                 160 
Lys Val Glu Arg Glu Ile Asp Gly Gly Leu Glu Thr Leu Arg Leu Lys
                165                 170                 175     
Leu Pro Ala Val Val Thr Ala Asp Leu Arg Leu Asn Glu Pro Arg Tyr
            180                 185                 190         
Ala Thr Leu Pro Asn Ile Met Lys Ala Lys Lys Lys Lys Ile Glu Val
        195                 200                 205             
Ile Lys Pro Gly Asp Leu Gly Val Asp Leu Thr Ser Lys Leu Ser Val
    210                 215                 220                 
Ile Ser Val Glu Asp Pro Pro Gln Arg Thr Ala Gly Val Lys Val Glu
225                 230                 235                 240 
Thr Thr Glu Asp Leu Val Ala Lys Leu Lys Glu Ile Gly Arg Ile
                245                 250                 255 


<210> 419
<211> 2033
<212> PRT
<213> Homo sapiens

<400> 419
Met Phe Lys Gly Leu Ser Lys Gly Ser Gln Gly Lys Gly Ser Pro Lys
 1               5                  10                  15      
Gly Ser Pro Ala Lys Gly Ser Pro Lys Gly Ser Pro Ser Arg His Ser
            20                  25                  30          
Arg Ala Ala Thr Gln Glu Leu Ala Leu Leu Ile Ser Arg Met Gln Ala
        35                  40                  45              
Asn Ala Asp Gln Val Glu Arg Asp Ile Leu Glu Thr Gln Lys Arg Leu
    50                  55                  60                  
Gln Gln Asp Arg Leu Asn Ser Glu Gln Ser Gln Ala Leu Gln His Gln
65                  70                  75                  80  
Gln Glu Thr Gly Arg Ser Leu Lys Glu Ala Glu Val Leu Leu Lys Asp
                85                  90                  95      
Leu Phe Leu Asp Val Asp Lys Ala Arg Arg Leu Lys His Pro Gln Ala
            100                 105                 110         
Glu Glu Ile Glu Lys Asp Ile Lys Gln Leu His Glu Arg Val Thr Gln
        115                 120                 125             
Glu Cys Ala Glu Tyr Arg Ala Leu Tyr Glu Lys Met Val Leu Pro Pro
    130                 135                 140                 
Asp Val Gly Pro Arg Val Asp Trp Ala Arg Val Leu Glu Gln Lys Gln
145                 150                 155                 160 
Lys Gln Val Cys Ala Gly Gln Tyr Gly Pro Gly Met Ala Glu Leu Glu
                165                 170                 175     
Gln Gln Ile Ala Glu His Asn Ile Leu Gln Lys Glu Ile Asp Ala Tyr
            180                 185                 190         
Gly Gln Gln Leu Arg Ser Leu Val Gly Pro Asp Ala Ala Thr Ile Arg
        195                 200                 205             
Ser Gln Tyr Arg Asp Leu Leu Lys Ala Ala Ser Trp Arg Gly Gln Ser
    210                 215                 220                 
Leu Gly Ser Leu Tyr Thr His Leu Gln Gly Cys Thr Arg Gln Leu Ser
225                 230                 235                 240 
Ala Leu Ala Glu Gln Gln Arg Arg Ile Leu Gln Gln Asp Trp Ser Asp
                245                 250                 255     
Leu Met Ala Asp Pro Ala Gly Val Arg Arg Glu Tyr Glu His Phe Lys
            260                 265                 270         
Gln His Glu Leu Leu Ser Gln Glu Gln Ser Val Asn Gln Leu Glu Asp
        275                 280                 285             
Asp Gly Glu Arg Met Val Glu Leu Arg His Pro Ala Val Gly Pro Ile
    290                 295                 300                 
Gln Ala His Gln Glu Ala Leu Lys Met Glu Trp Gln Asn Phe Leu Asn
305                 310                 315                 320 
Leu Cys Ile Cys Gln Glu Thr Gln Leu Gln His Val Glu Asp Tyr Arg
                325                 330                 335     
Arg Phe Gln Glu Glu Ala Asp Ser Val Ser Gln Thr Leu Ala Lys Leu
            340                 345                 350         
Asn Ser Asn Leu Asp Ala Lys Tyr Ser Pro Ala Pro Gly Gly Pro Pro
        355                 360                 365             
Gly Ala Pro Thr Glu Leu Leu Gln Gln Leu Glu Ala Glu Glu Lys Arg
    370                 375                 380                 
Leu Ala Val Thr Glu Arg Ala Thr Gly Asp Leu Gln Arg Arg Ser Arg
385                 390                 395                 400 
Asp Val Ala Pro Leu Pro Gln Arg Arg Asn Pro Pro Gln Gln Pro Leu
                405                 410                 415     
His Val Asp Ser Ile Cys Asp Trp Asp Ser Gly Glu Val Gln Leu Leu
            420                 425                 430         
Gln Gly Glu Arg Tyr Lys Leu Val Asp Asn Thr Glu Pro His Ala Trp
        435                 440                 445             
Val Val Gln Gly Pro Gly Gly Glu Thr Lys Arg Ala Pro Ala Ala Cys
    450                 455                 460                 
Phe Cys Ile Pro Ala Pro Asp Pro Asp Ala Val Ala Arg Ala Ser Arg
465                 470                 475                 480 
Leu Ala Ser Glu Leu Gln Ala Leu Lys Gln Lys Leu Ala Thr Val Gln
                485                 490                 495     
Ser Arg Leu Lys Ala Ser Ala Val Glu Ser Leu Arg Pro Ser Gln Gln
            500                 505                 510         
Ala Pro Ser Gly Ser Asp Leu Ala Asn Pro Gln Ala Gln Lys Leu Leu
        515                 520                 525             
Thr Gln Met Thr Arg Leu Asp Gly Asp Leu Gly Gln Ile Glu Arg Gln
    530                 535                 540                 
Val Leu Ala Trp Ala Arg Ala Pro Leu Ser Arg Pro Thr Pro Leu Glu
545                 550                 555                 560 
Asp Leu Glu Gly Arg Ile His Ser His Glu Gly Thr Ala Gln Arg Leu
                565                 570                 575     
Gln Ser Leu Gly Thr Glu Lys Glu Thr Ala Gln Lys Glu Cys Glu Ala
            580                 585                 590         
Phe Leu Ser Thr Arg Pro Val Gly Pro Ala Ala Leu Gln Leu Pro Val
        595                 600                 605             
Ala Leu Asn Ser Val Lys Asn Lys Phe Ser Asp Val Gln Val Leu Cys
    610                 615                 620                 
Ser Leu Tyr Gly Glu Lys Ala Lys Ala Ala Leu Asp Leu Glu Arg Gln
625                 630                 635                 640 
Ile Gln Asp Ala Asp Arg Val Ile Arg Gly Phe Glu Ala Thr Leu Val
                645                 650                 655     
Gln Glu Ala Pro Ile Pro Ala Glu Pro Gly Ala Leu Gln Glu Arg Val
            660                 665                 670         
Ser Glu Leu Gln Arg Gln Arg Arg Glu Leu Leu Glu Gln Gln Thr Cys
        675                 680                 685             
Val Leu Arg Leu His Arg Ala Leu Lys Ala Ser Glu His Ala Cys Ala
    690                 695                 700                 
Ala Leu Gln Asn Asn Phe Gln Glu Phe Cys Gln Asp Leu Pro Arg Gln
705                 710                 715                 720 
Gln Arg Gln Val Arg Ala Leu Thr Asp Arg Tyr His Ala Val Gly Asp
                725                 730                 735     
Gln Leu Asp Leu Arg Glu Lys Val Val Gln Asp Ala Ala Leu Thr Tyr
            740                 745                 750         
Gln Gln Phe Lys Asn Cys Lys Asp Asn Leu Ser Ser Trp Leu Glu His
        755                 760                 765             
Leu Pro Arg Ser Gln Val Arg Pro Ser Asp Gly Pro Ser Gln Ile Ala
    770                 775                 780                 
Tyr Lys Leu Gln Ala Gln Lys Arg Leu Thr Gln Glu Ile Gln Ser Arg
785                 790                 795                 800 
Glu Arg Asp Arg Ala Thr Ala Ser His Leu Ser Gln Ala Leu Gln Ala
                805                 810                 815     
Ala Leu Gln Asp Tyr Glu Leu Gln Ala Asp Thr Tyr Arg Cys Ser Leu
            820                 825                 830         
Glu Pro Thr Leu Ala Val Ser Ala Pro Lys Arg Pro Arg Val Ala Pro
        835                 840                 845             
Leu Gln Glu Ser Ile Gln Ala Gln Glu Lys Asn Leu Ala Lys Ala Tyr
    850                 855                 860                 
Thr Glu Val Ala Ala Ala Gln Gln Gln Leu Leu Gln Gln Leu Glu Phe
865                 870                 875                 880 
Ala Arg Lys Met Leu Glu Lys Lys Glu Leu Ser Glu Asp Ile Arg Arg
                885                 890                 895     
Thr His Asp Ala Lys Gln Gly Ser Glu Ser Pro Ala Gln Ala Gly Arg
            900                 905                 910         
Glu Ser Glu Ala Leu Lys Ala Gln Leu Glu Glu Glu Arg Lys Arg Val
        915                 920                 925             
Ala Arg Val Gln His Glu Leu Glu Ala Gln Arg Ser Gln Leu Leu Gln
    930                 935                 940                 
Leu Arg Thr Gln Arg Pro Leu Glu Arg Leu Glu Glu Lys Glu Val Val
945                 950                 955                 960 
Glu Phe Tyr Arg Asp Pro Gln Leu Glu Gly Ser Leu Ser Arg Val Lys
                965                 970                 975     
Ala Gln Val Glu Glu Glu Gly Lys Arg Arg Ala Gly Leu Gln Ala Asp
            980                 985                 990         
Leu Glu Val Ala Ala Gln Lys Val Val Gln Leu Glu Ser Lys Arg Lys
        995                 1000                1005            
Thr Met Gln Pro His Leu Leu Thr Lys Glu Val Thr Gln Val Glu Arg
    1010                1015                1020                
Asp Pro Gly Leu Asp Ser Gln Ala Ala Gln Leu Arg Ile Gln Ile Gln
1025                1030                1035                1040
Gln Leu Arg Gly Glu Asp Ala Val Ile Ser Ala Arg Leu Glu Gly Leu
                1045                1050                1055    
Lys Lys Glu Leu Leu Ala Leu Glu Lys Arg Glu Val Asp Val Lys Glu
            1060                1065                1070        
Lys Val Val Val Lys Glu Val Val Lys Val Glu Lys Asn Leu Glu Met
        1075                1080                1085            
Val Lys Ala Ala Gln Ala Leu Arg Leu Gln Met Glu Glu Asp Ala Ala
    1090                1095                1100                
Arg Arg Lys Gln Ala Glu Glu Ala Val Ala Lys Leu Gln Ala Arg Ile
1105                1110                1115                1120
Glu Asp Leu Glu Arg Ala Ile Ser Ser Val Glu Pro Lys Val Ile Val
                1125                1130                1135    
Lys Glu Val Lys Lys Val Glu Gln Asp Pro Gly Leu Leu Gln Glu Ser
            1140                1145                1150        
Ser Arg Leu Arg Ser Leu Leu Glu Glu Glu Arg Thr Lys Asn Ala Thr
        1155                1160                1165            
Leu Ala Arg Glu Leu Ser Asp Leu His Ser Lys Tyr Ser Val Val Glu
    1170                1175                1180                
Lys Gln Arg Pro Lys Val Gln Leu Gln Glu Arg Val His Glu Ile Phe
1185                1190                1195                1200
Gln Val Asp Pro Glu Thr Glu Gln Glu Ile Thr Arg Leu Lys Ala Lys
                1205                1210                1215    
Leu Gln Glu Met Ala Gly Lys Arg Ser Gly Val Glu Lys Glu Val Glu
            1220                1225                1230        
Lys Leu Leu Pro Asp Leu Glu Val Leu Arg Ala Gln Lys Pro Thr Val
        1235                1240                1245            
Glu Tyr Lys Glu Val Thr Gln Glu Val Val Arg His Glu Arg Ser Pro
    1250                1255                1260                
Glu Val Leu Arg Glu Ile Asp Arg Leu Lys Ala Gln Leu Asn Glu Leu
1265                1270                1275                1280
Val Asn Ser His Gly Arg Ser Gln Glu Gln Leu Ile Arg Leu Gln Gly
                1285                1290                1295    
Glu Arg Asp Glu Trp Arg Arg Glu Arg Ala Lys Val Glu Thr Lys Thr
            1300                1305                1310        
Val Ser Lys Glu Val Val Arg His Glu Lys Asp Pro Val Leu Glu Lys
        1315                1320                1325            
Glu Ala Glu Arg Leu Arg Gln Glu Val Arg Glu Ala Ala Gln Lys Arg
    1330                1335                1340                
Arg Ala Ala Glu Asp Ala Val Tyr Glu Leu Gln Ser Lys Arg Leu Leu
1345                1350                1355                1360
Leu Glu Arg Arg Lys Pro Glu Glu Lys Val Val Val Gln Glu Val Val
                1365                1370                1375    
Val Thr Gln Lys Asp Pro Lys Leu Arg Glu Glu His Ser Arg Leu Ser
            1380                1385                1390        
Gly Ser Leu Asp Glu Glu Val Gly Arg Arg Arg Gln Leu Glu Leu Glu
        1395                1400                1405            
Val Gln Gln Leu Arg Ala Gly Val Glu Glu Gln Glu Gly Leu Leu Ser
    1410                1415                1420                
Phe Gln Glu Asp Arg Ser Lys Lys Leu Ala Val Glu Arg Glu Leu Arg
1425                1430                1435                1440
Gln Leu Thr Leu Arg Ile Gln Glu Leu Glu Lys Arg Pro Pro Thr Val
                1445                1450                1455    
Gln Glu Lys Ile Ile Met Glu Glu Val Val Lys Leu Glu Lys Asp Pro
            1460                1465                1470        
Asp Leu Glu Lys Ser Thr Glu Ala Leu Arg Trp Asp Leu Asp Gln Glu
        1475                1480                1485            
Lys Thr Gln Val Thr Glu Leu Asn Arg Glu Cys Lys Asn Leu Gln Val
    1490                1495                1500                
Gln Ile Asp Val Leu Gln Lys Ala Lys Ser Gln Glu Lys Thr Ile Tyr
1505                1510                1515                1520
Lys Glu Val Ile Arg Val Gln Lys Asp Arg Val Leu Glu Asp Glu Arg
                1525                1530                1535    
Ala Arg Val Trp Glu Met Leu Asn Arg Glu Arg Thr Ala Arg Gln Ala
            1540                1545                1550        
Arg Glu Glu Glu Ala Arg Arg Leu Arg Glu Arg Ile Asp Arg Ala Glu
        1555                1560                1565            
Thr Leu Gly Arg Thr Trp Ser Arg Glu Glu Ser Glu Leu Gln Arg Ala
    1570                1575                1580                
Arg Asp Gln Ala Asp Gln Glu Cys Gly Arg Leu Gln Gln Glu Leu Arg
1585                1590                1595                1600
Ala Leu Glu Arg Gln Lys Gln Gln Gln Thr Leu Gln Leu Gln Glu Glu
                1605                1610                1615    
Ser Lys Leu Leu Ser Gln Lys Thr Glu Ser Glu Arg Gln Lys Ala Ala
            1620                1625                1630        
Gln Arg Gly Gln Glu Leu Ser Arg Leu Glu Ala Ala Ile Leu Arg Glu
        1635                1640                1645            
Lys Asp Gln Ile Tyr Glu Lys Glu Arg Thr Leu Arg Asp Leu His Ala
    1650                1655                1660                
Lys Val Ser Arg Glu Glu Leu Ser Gln Glu Thr Gln Thr Arg Glu Thr
1665                1670                1675                1680
Asn Leu Ser Thr Lys Ile Ser Ile Leu Glu Pro Glu Thr Gly Lys Asp
                1685                1690                1695    
Met Ser Pro Tyr Glu Ala Tyr Lys Arg Gly Ile Ile Asp Arg Gly Gln
            1700                1705                1710        
Tyr Leu Gln Leu Gln Glu Leu Glu Cys Asp Trp Glu Glu Val Thr Thr
        1715                1720                1725            
Ser Gly Pro Cys Gly Glu Glu Ser Val Leu Leu Asp Arg Lys Ser Gly
    1730                1735                1740                
Lys Gln Tyr Ser Ile Glu Ala Ala Leu Arg Cys Arg Arg Ile Ser Lys
1745                1750                1755                1760
Glu Glu Tyr His Leu Tyr Lys Asp Gly His Leu Pro Ile Ser Glu Phe
                1765                1770                1775    
Ala Leu Leu Val Ala Gly Glu Thr Lys Pro Ser Ser Ser Leu Ser Ile
            1780                1785                1790        
Gly Ser Ile Ile Ser Lys Ser Pro Leu Ala Ser Pro Ala Pro Gln Ser
        1795                1800                1805            
Thr Ser Phe Phe Ser Pro Ser Phe Ser Leu Gly Leu Gly Asp Asp Ser
    1810                1815                1820                
Phe Pro Ile Ala Gly Ile Tyr Asp Thr Thr Thr Asp Asn Lys Cys Ser
1825                1830                1835                1840
Ile Lys Thr Ala Val Ala Lys Asn Met Leu Asp Pro Ile Thr Gly Gln
                1845                1850                1855    
Lys Leu Leu Glu Ala Gln Ala Ala Thr Gly Gly Ile Val Asp Leu Leu
            1860                1865                1870        
Ser Arg Glu Arg Tyr Ser Val His Lys Ala Met Glu Arg Gly Leu Ile
        1875                1880                1885            
Glu Asn Thr Ser Thr Gln Arg Leu Leu Asn Ala Gln Lys Ala Phe Thr
    1890                1895                1900                
Gly Ile Glu Asp Pro Val Thr Lys Lys Arg Leu Ser Val Gly Glu Ala
1905                1910                1915                1920
Val Gln Lys Gly Trp Met Pro Arg Glu Ser Val Leu Pro His Leu Gln
                1925                1930                1935    
Val Gln His Leu Thr Gly Gly Leu Ile Asp Pro Lys Arg Thr Gly Arg
            1940                1945                1950        
Ile Pro Ile Gln Gln Ala Leu Leu Ser Gly Met Ile Ser Glu Glu Leu
        1955                1960                1965            
Ala Gln Leu Leu Gln Asp Glu Ser Ser Tyr Glu Lys Asp Leu Thr Asp
    1970                1975                1980                
Pro Ile Ser Lys Glu Arg Leu Ser Tyr Lys Glu Ala Met Gly Arg Cys
1985                1990                1995                2000
Arg Lys Asp Pro Leu Ser Gly Leu Leu Leu Leu Pro Ala Ala Leu Glu
                2005                2010                2015    
Gly Tyr Arg Cys Tyr Arg Ser Ala Ser Pro Thr Val Pro Arg Ser Leu
            2020                2025                2030        
Arg
    


<210> 420
<211> 699
<212> PRT
<213> Homo sapiens

<400> 420
Met Gln Ala His Glu Leu Phe Arg Tyr Phe Arg Met Pro Glu Leu Val
 1               5                  10                  15      
Asp Phe Arg Gln Cys Val Thr Leu Pro Thr Asn Thr Leu Met Gly Phe
            20                  25                  30          
Gly Ala Phe Ser Arg Arg Leu Thr Thr Phe Trp Arg Pro Arg His Pro
        35                  40                  45              
Lys Pro Leu Lys Pro Pro Trp His Leu Ser Met Gln Ser Val Glu Val
    50                  55                  60                  
Ala Gly Ser Gly Gly Ala Arg Arg Ser Ala Leu Leu Asp Ser Asp Glu
65                  70                  75                  80  
Pro Leu Val Tyr Phe Tyr Asp Asp Val Thr Thr Leu Tyr Glu Gly Phe
                85                  90                  95      
Gln Arg Gly Ile Gln Val Ser Asn Asn Gly Pro Cys Leu Gly Ser Arg
            100                 105                 110         
Lys Pro Asp Gln Pro Tyr Glu Trp Leu Ser Tyr Lys Gln Val Ala Glu
        115                 120                 125             
Leu Ser Glu Cys Ile Gly Ser Ala Leu Ile Gln Lys Gly Phe Lys Thr
    130                 135                 140                 
Ala Pro Asp Gln Phe Ile Gly Ile Phe Ala Gln Asn Arg Pro Glu Trp
145                 150                 155                 160 
Val Ile Ile Glu Gln Gly Cys Phe Ala Tyr Ser Met Val Ile Val Pro
                165                 170                 175     
Leu Tyr Asp Thr Leu Gly Asn Glu Ala Ile Thr Tyr Ile Val Asn Lys
            180                 185                 190         
Ala Glu Leu Ser Leu Val Phe Val Asp Lys Pro Glu Lys Ala Lys Leu
        195                 200                 205             
Leu Leu Glu Gly Val Glu Asn Lys Leu Ile Pro Gly Leu Lys Ile Ile
    210                 215                 220                 
Val Val Met Asp Ser Tyr Gly Ser Glu Leu Val Glu Arg Gly Gln Arg
225                 230                 235                 240 
Cys Gly Val Glu Val Thr Ser Met Lys Ala Met Glu Asp Leu Gly Arg
                245                 250                 255     
Ala Asn Arg Arg Lys Pro Lys Pro Pro Ala Pro Glu Asp Leu Ala Val
            260                 265                 270         
Ile Cys Phe Thr Ser Gly Thr Thr Gly Asn Pro Lys Gly Ala Met Val
        275                 280                 285             
Thr His Arg Asn Ile Val Ser Asp Cys Ser Ala Phe Val Lys Ala Thr
    290                 295                 300                 
Glu Asn Thr Val Asn Pro Cys Pro Asp Asp Thr Leu Ile Ser Phe Leu
305                 310                 315                 320 
Pro Leu Ala His Met Phe Glu Arg Val Val Glu Cys Val Met Leu Cys
                325                 330                 335     
His Gly Ala Lys Ile Gly Phe Phe Gln Gly Asp Ile Arg Leu Leu Met
            340                 345                 350         
Asp Asp Leu Lys Val Leu Gln Pro Thr Val Phe Pro Val Val Pro Arg
        355                 360                 365             
Leu Leu Asn Arg Met Phe Asp Arg Ile Phe Gly Gln Ala Asn Thr Thr
    370                 375                 380                 
Val Lys Arg Trp Leu Leu Asp Phe Ala Ser Lys Arg Lys Glu Ala Asp
385                 390                 395                 400 
Val Arg Ser Gly Ile Ile Arg Asn Asn Ser Leu Trp Asp Arg Leu Ile
                405                 410                 415     
Phe His Lys Val Gln Ser Ser Leu Gly Gly Arg Val Arg Leu Met Val
            420                 425                 430         
Thr Gly Ala Ala Pro Val Ser Ala Thr Val Leu Thr Phe Leu Arg Ala
        435                 440                 445             
Ala Leu Gly Cys Gln Phe Tyr Glu Gly Tyr Gly Gln Thr Glu Cys Thr
    450                 455                 460                 
Ala Gly Cys Cys Leu Thr Met Pro Gly Asp Trp Thr Thr Gly His Val
465                 470                 475                 480 
Gly Ala Pro Met Pro Cys Asn Leu Ile Lys Leu Gly Trp Gln Leu Glu
                485                 490                 495     
Glu Met Asn Tyr Met Ala Ser Glu Gly Glu Gly Glu Val Cys Val Lys
            500                 505                 510         
Gly Pro Asn Val Phe Gln Gly Tyr Leu Lys Asp Pro Ala Lys Thr Ala
        515                 520                 525             
Glu Ala Leu Asp Lys Asp Gly Trp Leu His Thr Gly Asp Ile Gly Lys
    530                 535                 540                 
Trp Leu Pro Asn Gly Thr Leu Lys Ile Ile Asp Arg Lys Lys His Ile
545                 550                 555                 560 
Phe Lys Leu Ala Gln Gly Glu Tyr Ile Ala Pro Glu Lys Ile Glu Asn
                565                 570                 575     
Ile Tyr Met Arg Ser Glu Pro Val Ala Gln Val Phe Val His Gly Glu
            580                 585                 590         
Ser Leu Gln Ala Phe Leu Ile Ala Ile Val Val Pro Asp Val Glu Thr
        595                 600                 605             
Leu Cys Ser Trp Ala Gln Lys Arg Gly Phe Glu Gly Ser Phe Glu Glu
    610                 615                 620                 
Leu Cys Arg Asn Lys Asp Val Lys Lys Ala Ile Leu Glu Asp Met Val
625                 630                 635                 640 
Arg Leu Gly Lys Asp Ser Gly Leu Lys Pro Phe Glu Gln Val Lys Gly
                645                 650                 655     
Ile Thr Leu His Pro Glu Leu Phe Ser Ile Asp Asn Gly Leu Leu Thr
            660                 665                 670         
Pro Thr Met Lys Ala Lys Arg Pro Glu Leu Arg Asn Tyr Phe Arg Ser
        675                 680                 685             
Gln Ile Asp Asp Leu Tyr Ser Ile Ile Lys Val
    690                 695                 


<210> 421
<211> 2911
<212> PRT
<213> Homo sapiens

<400> 421
Met Gly Arg Arg Arg Arg Leu Cys Leu Gln Leu Tyr Phe Leu Trp Leu
 1               5                  10                  15      
Gly Cys Val Val Leu Trp Ala Gln Gly Thr Ala Gly Gln Pro Gln Pro
            20                  25                  30          
Pro Pro Pro Lys Pro Pro Arg Pro Gln Pro Pro Pro Gln Gln Val Arg
        35                  40                  45              
Ser Ala Thr Ala Gly Ser Glu Gly Gly Phe Leu Ala Pro Glu Tyr Arg
    50                  55                  60                  
Glu Glu Gly Ala Ala Val Ala Ser Arg Val Arg Arg Arg Gly Gln Gln
65                  70                  75                  80  
Asp Val Leu Arg Gly Pro Asn Val Cys Gly Ser Arg Phe His Ser Tyr
                85                  90                  95      
Cys Cys Pro Gly Trp Lys Thr Leu Pro Gly Gly Asn Gln Cys Ile Val
            100                 105                 110         
Pro Ile Cys Arg Asn Ser Cys Gly Asp Gly Phe Cys Ser Arg Pro Asn
        115                 120                 125             
Met Cys Thr Cys Ser Ser Gly Gln Ile Ser Ser Thr Cys Gly Ser Lys
    130                 135                 140                 
Ser Ile Gln Gln Cys Ser Val Arg Cys Met Asn Gly Gly Thr Cys Ala
145                 150                 155                 160 
Asp Asp His Cys Gln Cys Gln Lys Gly Tyr Ile Gly Thr Tyr Cys Gly
                165                 170                 175     
Gln Pro Val Cys Glu Asn Gly Cys Gln Asn Gly Gly Arg Cys Ile Ala
            180                 185                 190         
Gln Pro Cys Ala Cys Val Tyr Gly Phe Thr Gly Pro Gln Cys Glu Arg
        195                 200                 205             
Asp Tyr Arg Thr Gly Pro Cys Phe Thr Gln Val Asn Asn Gln Met Cys
    210                 215                 220                 
Gln Gly Gln Leu Thr Gly Ile Val Cys Thr Lys Thr Leu Cys Cys Ala
225                 230                 235                 240 
Thr Thr Gly Arg Ala Trp Gly His Pro Cys Glu Met Cys Pro Ala Gln
                245                 250                 255     
Pro Gln Pro Cys Arg Arg Gly Phe Ile Pro Asn Ile Arg Thr Gly Ala
            260                 265                 270         
Cys Gln Asp Val Asp Glu Cys Gln Ala Ile Pro Gly Ile Cys Gln Gly
        275                 280                 285             
Gly Asn Cys Ile Asn Thr Val Gly Ser Phe Glu Cys Arg Cys Pro Ala
    290                 295                 300                 
Gly His Lys Gln Ser Glu Thr Thr Gln Lys Cys Glu Asp Ile Asp Glu
305                 310                 315                 320 
Cys Ser Ile Ile Pro Gly Ile Cys Glu Thr Gly Glu Cys Ser Asn Thr
                325                 330                 335     
Val Gly Ser Tyr Phe Cys Val Cys Pro Arg Gly Tyr Val Thr Ser Thr
            340                 345                 350         
Asp Gly Ser Arg Cys Ile Asp Gln Arg Thr Gly Met Cys Phe Ser Gly
        355                 360                 365             
Leu Val Asn Gly Arg Cys Ala Gln Glu Leu Pro Gly Arg Met Thr Lys
    370                 375                 380                 
Met Gln Cys Cys Cys Glu Pro Gly Arg Cys Trp Gly Ile Gly Thr Ile
385                 390                 395                 400 
Pro Glu Ala Cys Pro Val Arg Gly Ser Glu Glu Tyr Arg Arg Leu Cys
                405                 410                 415     
Met Asp Gly Leu Pro Met Gly Gly Ile Pro Gly Ser Ala Gly Ser Arg
            420                 425                 430         
Pro Gly Gly Thr Gly Gly Asn Gly Phe Ala Pro Ser Gly Asn Gly Asn
        435                 440                 445             
Gly Tyr Gly Pro Gly Gly Thr Gly Phe Ile Pro Ile Pro Gly Gly Asn
    450                 455                 460                 
Gly Phe Ser Pro Gly Val Gly Gly Ala Gly Val Gly Ala Gly Gly Gln
465                 470                 475                 480 
Gly Pro Ile Ile Thr Gly Leu Thr Ile Leu Asn Gln Thr Ile Asp Ile
                485                 490                 495     
Cys Lys His His Ala Asn Leu Cys Leu Asn Gly Arg Cys Ile Pro Thr
            500                 505                 510         
Val Ser Ser Tyr Arg Cys Glu Cys Asn Met Gly Tyr Lys Gln Asp Ala
        515                 520                 525             
Asn Gly Asp Cys Ile Asp Val Asp Glu Cys Thr Ser Asn Pro Cys Thr
    530                 535                 540                 
Asn Gly Asp Cys Val Asn Thr Pro Gly Ser Tyr Tyr Cys Lys Cys His
545                 550                 555                 560 
Ala Gly Phe Gln Arg Thr Pro Thr Lys Gln Ala Cys Ile Asp Ile Asp
                565                 570                 575     
Glu Cys Ile Gln Asn Gly Val Leu Cys Lys Asn Gly Arg Cys Val Asn
            580                 585                 590         
Ser Asp Gly Ser Phe Gln Cys Ile Cys Asn Ala Gly Phe Glu Leu Thr
        595                 600                 605             
Thr Asp Gly Lys Asn Cys Val Asp His Asp Glu Cys Thr Thr Thr Asn
    610                 615                 620                 
Met Cys Leu Asn Gly Met Cys Ile Asn Glu Asp Gly Ser Phe Lys Cys
625                 630                 635                 640 
Ile Cys Lys Pro Gly Phe Val Leu Ala Pro Asn Gly Arg Tyr Cys Thr
                645                 650                 655     
Asp Val Asp Glu Cys Gln Thr Pro Gly Ile Cys Met Asn Gly His Cys
            660                 665                 670         
Ile Asn Ser Glu Gly Ser Phe Arg Cys Asp Cys Pro Pro Gly Leu Ala
        675                 680                 685             
Val Gly Met Asp Gly Arg Val Cys Val Asp Thr His Met Arg Ser Thr
    690                 695                 700                 
Cys Tyr Gly Gly Ile Lys Lys Gly Val Cys Val Arg Pro Phe Pro Gly
705                 710                 715                 720 
Ala Val Thr Lys Ser Glu Cys Cys Cys Ala Asn Pro Asp Tyr Gly Phe
                725                 730                 735     
Gly Glu Pro Cys Gln Pro Cys Pro Ala Lys Asn Ser Ala Glu Phe His
            740                 745                 750         
Gly Leu Cys Ser Ser Gly Val Gly Ile Thr Val Asp Gly Arg Asp Ile
        755                 760                 765             
Asn Glu Cys Ala Leu Asp Pro Asp Ile Cys Ala Asn Gly Ile Cys Glu
    770                 775                 780                 
Asn Leu Arg Gly Ser Tyr Arg Cys Asn Cys Asn Ser Gly Tyr Glu Pro
785                 790                 795                 800 
Asp Ala Ser Gly Arg Asn Cys Ile Asp Ile Asp Glu Cys Leu Val Asn
                805                 810                 815     
Arg Leu Leu Cys Asp Asn Gly Leu Cys Arg Asn Thr Pro Gly Ser Tyr
            820                 825                 830         
Ser Cys Thr Cys Pro Pro Gly Tyr Val Phe Arg Thr Glu Thr Glu Thr
        835                 840                 845             
Cys Glu Asp Ile Asn Glu Cys Glu Ser Asn Pro Cys Val Asn Gly Ala
    850                 855                 860                 
Cys Arg Asn Asn Leu Gly Ser Phe Asn Cys Glu Cys Ser Pro Gly Ser
865                 870                 875                 880 
Lys Leu Ser Ser Thr Gly Leu Ile Cys Ile Asp Ser Leu Lys Gly Thr
                885                 890                 895     
Cys Trp Leu Asn Ile Gln Asp Ser Arg Cys Glu Val Asn Ile Asn Gly
            900                 905                 910         
Ala Thr Leu Lys Ser Glu Cys Cys Ala Thr Leu Gly Ala Ala Trp Gly
        915                 920                 925             
Ser Pro Cys Glu Arg Cys Glu Leu Asp Thr Ala Cys Pro Arg Gly Leu
    930                 935                 940                 
Ala Arg Ile Lys Gly Val Thr Cys Glu Asp Val Asn Glu Cys Glu Val
945                 950                 955                 960 
Phe Pro Gly Val Cys Pro Asn Gly Arg Cys Val Asn Ser Lys Gly Ser
                965                 970                 975     
Phe His Cys Glu Cys Pro Glu Gly Leu Thr Leu Asp Gly Thr Gly Arg
            980                 985                 990         
Val Cys Leu Asp Ile Arg Met Glu Gln Cys Tyr Leu Lys Trp Asp Glu
        995                 1000                1005            
Asp Glu Cys Ile His Pro Val Pro Gly Lys Phe Arg Met Asp Ala Cys
    1010                1015                1020                
Cys Cys Ala Val Gly Ala Ala Trp Gly Thr Glu Cys Glu Glu Cys Pro
1025                1030                1035                1040
Lys Pro Gly Thr Lys Glu Tyr Glu Thr Leu Cys Pro Arg Gly Ala Gly
                1045                1050                1055    
Phe Ala Asn Arg Gly Asp Val Leu Thr Gly Arg Pro Phe Tyr Lys Asp
            1060                1065                1070        
Ile Asn Glu Cys Lys Ala Phe Pro Gly Met Cys Thr Tyr Gly Lys Cys
        1075                1080                1085            
Arg Asn Thr Ile Gly Ser Phe Lys Cys Arg Cys Asn Ser Gly Phe Ala
    1090                1095                1100                
Leu Asp Met Glu Glu Arg Asn Cys Thr Asp Ile Asp Glu Cys Arg Ile
1105                1110                1115                1120
Ser Pro Asp Leu Cys Gly Ser Gly Ile Cys Val Asn Thr Pro Gly Ser
                1125                1130                1135    
Phe Glu Cys Glu Cys Phe Glu Gly Tyr Glu Ser Gly Phe Met Met Met
            1140                1145                1150        
Lys Asn Cys Met Asp Ile Asp Gly Cys Glu Arg Asn Pro Leu Leu Cys
        1155                1160                1165            
Arg Gly Gly Thr Cys Val Asn Thr Glu Gly Ser Phe Gln Cys Asp Cys
    1170                1175                1180                
Pro Leu Gly His Glu Leu Ser Pro Ser Arg Glu Asp Cys Val Asp Ile
1185                1190                1195                1200
Asn Glu Cys Ser Leu Ser Asp Asn Leu Cys Arg Asn Gly Lys Cys Val
                1205                1210                1215    
Asn Met Ile Gly Thr Tyr Gln Cys Ser Cys Asn Pro Gly Tyr Gln Ala
            1220                1225                1230        
Thr Pro Asp Arg Gln Gly Cys Thr Asp Ile Asp Glu Cys Met Ile Met
        1235                1240                1245            
Asn Gly Gly Cys Asp Thr Gln Cys Thr Asn Ser Glu Gly Ser Tyr Glu
    1250                1255                1260                
Cys Ser Cys Ser Glu Gly Tyr Ala Leu Met Pro Asp Gly Arg Ser Cys
1265                1270                1275                1280
Ala Asp Ile Asp Glu Cys Glu Asn Asn Pro Asp Ile Cys Asp Gly Gly
                1285                1290                1295    
Gln Cys Thr Asn Ile Pro Gly Glu Tyr Arg Cys Leu Cys Tyr Asp Gly
            1300                1305                1310        
Phe Met Ala Ser Met Asp Met Lys Thr Cys Ile Asp Val Asn Glu Cys
        1315                1320                1325            
Asp Leu Asn Ser Asn Ile Cys Met Phe Gly Glu Cys Glu Asn Thr Lys
    1330                1335                1340                
Gly Ser Phe Ile Cys His Cys Gln Leu Gly Tyr Ser Val Lys Lys Gly
1345                1350                1355                1360
Thr Thr Gly Cys Thr Asp Val Asp Glu Cys Glu Ile Gly Ala His Asn
                1365                1370                1375    
Cys Asp Met His Ala Ser Cys Leu Asn Ile Pro Gly Ser Phe Lys Cys
            1380                1385                1390        
Ser Cys Arg Glu Gly Trp Ile Gly Asn Gly Ile Lys Cys Ile Asp Leu
        1395                1400                1405            
Asp Glu Cys Ser Asn Gly Thr His Gln Cys Ser Ile Asn Ala Gln Cys
    1410                1415                1420                
Val Asn Thr Pro Gly Ser Tyr Arg Cys Ala Cys Ser Glu Gly Phe Thr
1425                1430                1435                1440
Gly Asp Gly Phe Thr Cys Ser Asp Val Asp Glu Cys Ala Glu Asn Ile
                1445                1450                1455    
Asn Leu Cys Glu Asn Gly Gln Cys Leu Asn Val Pro Gly Ala Tyr Arg
            1460                1465                1470        
Cys Glu Cys Glu Met Gly Phe Thr Pro Ala Ser Asp Ser Arg Ser Cys
        1475                1480                1485            
Gln Asp Ile Asp Glu Cys Ser Phe Gln Asn Ile Cys Val Ser Gly Thr
    1490                1495                1500                
Cys Asn Asn Leu Pro Gly Met Phe His Cys Ile Cys Asp Asp Gly Tyr
1505                1510                1515                1520
Glu Leu Asp Arg Thr Gly Gly Asn Cys Thr Asp Ile Asp Glu Cys Ala
                1525                1530                1535    
Asp Pro Ile Asn Cys Val Asn Gly Leu Cys Val Asn Thr Pro Gly Arg
            1540                1545                1550        
Tyr Glu Cys Asn Cys Pro Pro Asp Phe Gln Leu Asn Pro Thr Gly Val
        1555                1560                1565            
Gly Cys Val Asp Asn Arg Val Gly Asn Cys Tyr Leu Lys Phe Gly Pro
    1570                1575                1580                
Arg Gly Asp Gly Ser Leu Ser Cys Asn Thr Glu Ile Gly Val Gly Val
1585                1590                1595                1600
Ser Arg Ser Ser Cys Cys Cys Ser Leu Gly Lys Ala Trp Gly Asn Pro
                1605                1610                1615    
Cys Glu Thr Cys Pro Pro Val Asn Ser Thr Glu Tyr Tyr Thr Leu Cys
            1620                1625                1630        
Pro Gly Gly Glu Gly Phe Arg Pro Asn Pro Ile Thr Ile Ile Leu Glu
        1635                1640                1645            
Asp Ile Asp Glu Cys Gln Glu Leu Pro Gly Leu Cys Gln Gly Gly Asn
    1650                1655                1660                
Cys Ile Asn Thr Phe Gly Ser Phe Gln Cys Glu Cys Pro Gln Gly Tyr
1665                1670                1675                1680
Tyr Leu Ser Glu Asp Thr Arg Ile Cys Glu Asp Ile Asp Glu Cys Phe
                1685                1690                1695    
Ala His Pro Gly Val Cys Gly Pro Gly Thr Cys Tyr Asn Thr Leu Gly
            1700                1705                1710        
Asn Tyr Thr Cys Ile Cys Pro Pro Glu Tyr Met Gln Val Asn Gly Gly
        1715                1720                1725            
His Asn Cys Met Asp Met Arg Lys Ser Phe Cys Tyr Arg Ser Tyr Asn
    1730                1735                1740                
Gly Thr Thr Cys Glu Asn Glu Leu Pro Phe Asn Val Thr Lys Arg Met
1745                1750                1755                1760
Cys Cys Cys Thr Tyr Asn Val Gly Lys Ala Gly Asn Lys Pro Cys Glu
                1765                1770                1775    
Pro Cys Pro Thr Pro Gly Thr Ala Asp Phe Lys Thr Ile Cys Gly Asn
            1780                1785                1790        
Ile Pro Gly Phe Thr Phe Asp Ile His Thr Gly Lys Ala Val Asp Ile
        1795                1800                1805            
Asp Glu Cys Lys Glu Ile Pro Gly Ile Cys Ala Asn Gly Val Cys Ile
    1810                1815                1820                
Asn Gln Ile Gly Ser Phe Arg Cys Glu Cys Pro Thr Gly Phe Ser Tyr
1825                1830                1835                1840
Asn Asp Leu Leu Leu Val Cys Glu Asp Ile Asp Glu Cys Ser Asn Gly
                1845                1850                1855    
Asp Asn Leu Cys Gln Arg Asn Ala Asp Cys Ile Asn Ser Pro Gly Ser
            1860                1865                1870        
Tyr Arg Cys Glu Cys Ala Ala Gly Phe Lys Leu Ser Pro Asn Gly Ala
        1875                1880                1885            
Cys Val Asp Arg Asn Glu Cys Leu Glu Ile Pro Asn Val Cys Ser His
    1890                1895                1900                
Gly Leu Cys Val Asp Leu Gln Gly Ser Tyr Gln Cys Ile Cys His Asn
1905                1910                1915                1920
Gly Phe Lys Ala Ser Gln Asp Gln Thr Met Cys Met Asp Val Asp Glu
                1925                1930                1935    
Cys Glu Arg His Pro Cys Gly Asn Gly Thr Cys Lys Asn Thr Val Gly
            1940                1945                1950        
Ser Tyr Asn Cys Leu Cys Tyr Pro Gly Phe Glu Leu Thr His Asn Asn
        1955                1960                1965            
Asp Cys Leu Asp Ile Asp Glu Cys Ser Ser Phe Phe Gly Gln Val Cys
    1970                1975                1980                
Arg Asn Gly Arg Cys Phe Asn Glu Ile Gly Ser Phe Lys Cys Leu Cys
1985                1990                1995                2000
Asn Glu Gly Tyr Glu Leu Thr Pro Asp Gly Lys Asn Cys Ile Asp Thr
                2005                2010                2015    
Asn Glu Cys Val Ala Leu Pro Gly Ser Cys Ser Pro Gly Thr Cys Gln
            2020                2025                2030        
Asn Leu Glu Gly Ser Phe Arg Cys Ile Cys Pro Pro Gly Tyr Glu Val
        2035                2040                2045            
Lys Ser Glu Asn Cys Ile Asp Ile Asn Glu Cys Asp Glu Asp Pro Asn
    2050                2055                2060                
Ile Cys Leu Phe Gly Ser Cys Thr Asn Thr Pro Gly Gly Phe Gln Cys
2065                2070                2075                2080
Leu Cys Pro Pro Gly Phe Val Leu Ser Asp Asn Gly Arg Arg Cys Phe
                2085                2090                2095    
Asp Thr Arg Gln Ser Phe Cys Phe Thr Asn Phe Glu Asn Gly Lys Cys
            2100                2105                2110        
Ser Val Pro Lys Ala Phe Asn Thr Thr Lys Ala Lys Cys Cys Cys Ser
        2115                2120                2125            
Lys Met Pro Gly Glu Gly Trp Gly Asp Pro Cys Glu Leu Cys Pro Lys
    2130                2135                2140                
Asp Asp Glu Val Ala Phe Gln Asp Leu Cys Pro Tyr Gly His Gly Thr
2145                2150                2155                2160
Val Pro Ser Leu His Asp Thr Arg Glu Asp Val Asn Glu Cys Leu Glu
                2165                2170                2175    
Ser Pro Gly Ile Cys Ser Asn Gly Gln Cys Ile Asn Thr Asp Gly Ser
            2180                2185                2190        
Phe Arg Cys Glu Cys Pro Met Gly Tyr Asn Leu Asp Tyr Thr Gly Val
        2195                2200                2205            
Arg Cys Val Asp Thr Asp Glu Cys Ser Ile Gly Asn Pro Cys Gly Asn
    2210                2215                2220                
Gly Thr Cys Thr Asn Val Ile Gly Ser Phe Glu Cys Asn Cys Asn Glu
2225                2230                2235                2240
Gly Phe Glu Pro Gly Pro Met Met Asn Cys Glu Asp Ile Asn Glu Cys
                2245                2250                2255    
Ala Gln Asn Pro Leu Leu Cys Ala Leu Arg Cys Met Asn Thr Phe Gly
            2260                2265                2270        
Ser Tyr Glu Cys Thr Cys Pro Ile Gly Tyr Ala Leu Arg Glu Asp Gln
        2275                2280                2285            
Lys Met Cys Lys Asp Leu Asp Glu Cys Ala Glu Gly Leu His Asp Cys
    2290                2295                2300                
Glu Ser Arg Gly Met Met Cys Lys Asn Leu Ile Gly Thr Phe Met Cys
2305                2310                2315                2320
Ile Cys Pro Pro Gly Met Ala Arg Arg Pro Asp Gly Glu Gly Cys Val
                2325                2330                2335    
Asp Glu Asn Glu Cys Arg Thr Lys Pro Gly Ile Cys Glu Asn Gly Arg
            2340                2345                2350        
Cys Val Asn Ile Ile Gly Ser Tyr Arg Cys Glu Cys Asn Glu Gly Phe
        2355                2360                2365            
Gln Ser Ser Ser Ser Gly Thr Glu Cys Leu Asp Asn Arg Gln Gly Leu
    2370                2375                2380                
Cys Phe Ala Glu Val Leu Gln Thr Ile Cys Gln Met Ala Ser Ser Ser
2385                2390                2395                2400
Arg Asn Leu Val Thr Lys Ser Glu Cys Cys Cys Asp Gly Gly Arg Gly
                2405                2410                2415    
Trp Gly His Gln Cys Glu Leu Cys Pro Leu Pro Gly Thr Ala Gln Tyr
            2420                2425                2430        
Lys Lys Ile Cys Pro His Gly Pro Gly Tyr Thr Thr Asp Gly Arg Asp
        2435                2440                2445            
Ile Asp Glu Cys Lys Val Met Pro Asn Leu Cys Thr Asn Gly Gln Cys
    2450                2455                2460                
Ile Asn Thr Met Gly Ser Phe Arg Cys Phe Cys Lys Val Gly Tyr Thr
2465                2470                2475                2480
Thr Asp Ile Ser Gly Thr Ser Cys Ile Asp Leu Asp Glu Cys Ser Gln
                2485                2490                2495    
Ser Pro Lys Pro Cys Asn Tyr Ile Cys Lys Asn Thr Glu Gly Ser Tyr
            2500                2505                2510        
Gln Cys Ser Cys Pro Arg Gly Tyr Val Leu Gln Glu Asp Gly Lys Thr
        2515                2520                2525            
Cys Lys Asp Leu Asp Glu Cys Gln Thr Lys Gln His Asn Cys Gln Phe
    2530                2535                2540                
Leu Cys Val Asn Thr Leu Gly Gly Phe Thr Cys Lys Cys Pro Pro Gly
2545                2550                2555                2560
Phe Thr Gln His His Thr Ala Cys Ile Asp Asn Asn Glu Cys Gly Ser
                2565                2570                2575    
Gln Pro Leu Leu Cys Gly Gly Lys Gly Ile Cys Gln Asn Thr Pro Gly
            2580                2585                2590        
Ser Phe Ser Cys Glu Cys Gln Arg Gly Phe Ser Leu Asp Ala Thr Gly
        2595                2600                2605            
Leu Asn Cys Glu Asp Val Asp Glu Cys Asp Gly Asn His Arg Cys Gln
    2610                2615                2620                
His Gly Cys Gln Asn Ile Leu Gly Gly Tyr Arg Cys Gly Cys Pro Gln
2625                2630                2635                2640
Gly Tyr Ile Gln His Tyr Gln Trp Asn Gln Cys Val Asp Glu Asn Glu
                2645                2650                2655    
Cys Ser Asn Pro Asn Ala Cys Gly Ser Ala Ser Cys Tyr Asn Thr Leu
            2660                2665                2670        
Gly Ser Tyr Lys Cys Ala Cys Pro Ser Gly Phe Ser Phe Asp Gln Phe
        2675                2680                2685            
Ser Ser Ala Cys His Asp Val Asn Glu Cys Ser Ser Ser Lys Asn Pro
    2690                2695                2700                
Cys Asn Tyr Gly Cys Ser Asn Thr Glu Gly Gly Tyr Leu Cys Gly Cys
2705                2710                2715                2720
Pro Pro Gly Tyr Tyr Arg Val Gly Gln Gly His Cys Val Ser Gly Met
                2725                2730                2735    
Gly Phe Asn Lys Gly Gln Tyr Leu Ser Leu Asp Thr Glu Val Asp Glu
            2740                2745                2750        
Glu Asn Ala Leu Ser Pro Glu Ala Cys Tyr Glu Cys Lys Ile Asn Gly
        2755                2760                2765            
Tyr Pro Lys Lys Asp Ser Arg Gln Lys Arg Ser Ile His Glu Pro Asp
    2770                2775                2780                
Pro Thr Ala Val Glu Gln Ile Ser Leu Glu Ser Val Asp Met Asp Ser
2785                2790                2795                2800
Pro Val Asn Met Lys Phe Asn Leu Ser His Leu Gly Ser Lys Glu His
                2805                2810                2815    
Ile Leu Glu Leu Arg Pro Ala Ile Gln Pro Leu Asn Asn His Ile Arg
            2820                2825                2830        
Tyr Val Ile Ser Gln Gly Asn Asp Asp Ser Val Phe Arg Ile His Gln
        2835                2840                2845            
Arg Asn Gly Leu Ser Tyr Leu His Thr Ala Lys Lys Lys Leu Met Pro
    2850                2855                2860                
Gly Thr Tyr Thr Leu Glu Ile Thr Ser Ile Pro Leu Tyr Lys Lys Lys
2865                2870                2875                2880
Glu Leu Lys Lys Leu Glu Glu Ser Asn Glu Asp Asp Tyr Leu Leu Gly
                2885                2890                2895    
Glu Leu Gly Glu Ala Leu Arg Met Arg Leu Gln Ile Gln Leu Tyr
            2900                2905                2910    


<210> 422
<211> 327
<212> PRT
<213> Homo sapiens

<400> 422
Met Gly Gly Ser Ala Leu Asn Gln Gly Val Leu Glu Gly Asp Asp Ala
 1               5                  10                  15      
Pro Gly Gln Ser Leu Tyr Glu Arg Leu Ser Gln Arg Met Leu Asp Ile
            20                  25                  30          
Ser Gly Asp Arg Gly Val Leu Lys Asp Val Ile Arg Glu Gly Ala Gly
        35                  40                  45              
Asp Leu Val Ala Pro Asp Ala Ser Val Leu Val Lys Tyr Ser Gly Tyr
    50                  55                  60                  
Leu Glu His Met Asp Arg Pro Phe Asp Ser Asn Tyr Phe Arg Lys Thr
65                  70                  75                  80  
Pro Arg Leu Met Lys Leu Gly Glu Asp Ile Thr Leu Trp Gly Met Glu
                85                  90                  95      
Leu Gly Leu Leu Ser Met Arg Arg Gly Glu Leu Ala Arg Phe Leu Phe
            100                 105                 110         
Lys Pro Asn Tyr Ala Tyr Gly Thr Leu Gly Cys Pro Pro Leu Ile Pro
        115                 120                 125             
Pro Asn Thr Thr Val Leu Phe Glu Ile Glu Leu Leu Asp Phe Leu Asp
    130                 135                 140                 
Cys Ala Glu Ser Asp Lys Phe Cys Ala Leu Ser Ala Glu Gln Gln Asp
145                 150                 155                 160 
Gln Phe Pro Leu Gln Lys Val Leu Lys Val Ala Ala Thr Glu Arg Glu
                165                 170                 175     
Phe Gly Asn Tyr Leu Phe Arg Gln Asn Arg Phe Tyr Asp Ala Lys Val
            180                 185                 190         
Arg Tyr Lys Arg Ala Leu Leu Leu Leu Arg Arg Arg Ser Ala Pro Pro
        195                 200                 205             
Glu Glu Gln His Leu Val Glu Ala Ala Lys Leu Pro Val Leu Leu Asn
    210                 215                 220                 
Leu Ser Phe Thr Tyr Leu Lys Leu Asp Arg Pro Thr Ile Ala Leu Cys
225                 230                 235                 240 
Tyr Gly Glu Gln Ala Leu Ile Ile Asp Gln Lys Asn Ala Lys Ala Leu
                245                 250                 255     
Phe Arg Cys Gly Gln Ala Cys Leu Leu Leu Thr Glu Tyr Gln Lys Ala
            260                 265                 270         
Arg Asp Phe Leu Val Arg Ala Gln Lys Glu Gln Pro Phe Asn His Asp
        275                 280                 285             
Ile Asn Asn Glu Leu Lys Lys Leu Ala Ser Cys Tyr Arg Asp Tyr Val
    290                 295                 300                 
Asp Lys Glu Lys Glu Met Trp His Arg Met Phe Ala Pro Cys Gly Asp
305                 310                 315                 320 
Gly Ser Thr Ala Gly Glu Ser
                325         


<210> 423
<211> 591
<212> PRT
<213> Homo sapiens

<400> 423
Met Ala Val Ala Pro Leu Arg Gly Ala Leu Leu Leu Trp Gln Leu Leu
 1               5                  10                  15      
Ala Ala Gly Gly Ala Ala Leu Glu Ile Gly Arg Phe Asp Pro Glu Arg
            20                  25                  30          
Gly Arg Gly Ala Ala Pro Cys Gln Ala Val Glu Ile Pro Met Cys Arg
        35                  40                  45              
Gly Ile Gly Tyr Asn Leu Thr Arg Met Pro Asn Leu Leu Gly His Thr
    50                  55                  60                  
Ser Gln Gly Glu Ala Ala Ala Glu Leu Ala Glu Phe Ala Pro Leu Val
65                  70                  75                  80  
Gln Tyr Gly Cys His Ser His Leu Arg Phe Phe Leu Cys Ser Leu Tyr
                85                  90                  95      
Ala Pro Met Cys Thr Asp Gln Val Ser Thr Pro Ile Pro Ala Cys Arg
            100                 105                 110         
Pro Met Cys Glu Gln Ala Arg Leu Arg Cys Ala Pro Ile Met Glu Gln
        115                 120                 125             
Phe Asn Phe Gly Trp Pro Asp Ser Leu Asp Cys Ala Arg Leu Pro Thr
    130                 135                 140                 
Arg Asn Asp Pro His Ala Leu Cys Met Glu Ala Pro Glu Asn Ala Thr
145                 150                 155                 160 
Ala Gly Pro Ala Glu Pro His Lys Gly Leu Gly Met Leu Pro Val Ala
                165                 170                 175     
Pro Arg Pro Ala Arg Pro Pro Gly Asp Leu Gly Pro Gly Ala Gly Gly
            180                 185                 190         
Ser Gly Thr Cys Glu Asn Pro Glu Lys Phe Gln Tyr Val Glu Lys Ser
        195                 200                 205             
Arg Ser Cys Ala Pro Arg Cys Gly Pro Gly Val Glu Val Phe Trp Ser
    210                 215                 220                 
Arg Arg Asp Lys Asp Phe Ala Leu Val Trp Met Ala Val Trp Ser Ala
225                 230                 235                 240 
Leu Cys Phe Phe Ser Thr Ala Phe Thr Val Leu Thr Phe Leu Leu Glu
                245                 250                 255     
Pro His Arg Phe Gln Tyr Pro Glu Arg Pro Ile Ile Phe Leu Ser Met
            260                 265                 270         
Cys Tyr Asn Val Tyr Ser Leu Ala Phe Leu Ile Arg Ala Val Ala Gly
        275                 280                 285             
Ala Gln Ser Val Ala Cys Asp Gln Glu Ala Gly Ala Leu Tyr Val Ile
    290                 295                 300                 
Gln Glu Gly Leu Glu Asn Thr Gly Cys Thr Leu Val Phe Leu Leu Leu
305                 310                 315                 320 
Tyr Tyr Phe Gly Met Ala Ser Ser Leu Trp Trp Val Val Leu Thr Leu
                325                 330                 335     
Thr Trp Phe Leu Ala Ala Gly Lys Lys Trp Gly His Glu Ala Ile Glu
            340                 345                 350         
Ala His Gly Ser Tyr Phe His Met Ala Ala Trp Gly Leu Pro Ala Leu
        355                 360                 365             
Lys Thr Ile Val Ile Leu Thr Leu Arg Lys Val Ala Gly Asp Glu Leu
    370                 375                 380                 
Thr Gly Leu Cys Tyr Val Ala Ser Thr Asp Ala Ala Ala Leu Thr Gly
385                 390                 395                 400 
Phe Val Leu Val Pro Leu Ser Gly Tyr Leu Val Leu Gly Ser Ser Phe
                405                 410                 415     
Leu Leu Thr Gly Phe Val Ala Leu Phe His Ile Arg Lys Ile Met Lys
            420                 425                 430         
Thr Gly Gly Thr Asn Thr Glu Lys Leu Glu Lys Leu Met Val Lys Ile
        435                 440                 445             
Gly Val Phe Ser Ile Leu Tyr Thr Val Pro Ala Thr Cys Val Ile Val
    450                 455                 460                 
Cys Tyr Val Tyr Glu Arg Leu Asn Met Asp Phe Trp Arg Leu Arg Ala
465                 470                 475                 480 
Thr Glu Gln Pro Cys Ala Ala Ala Ala Gly Pro Gly Gly Arg Arg Asp
                485                 490                 495     
Cys Ser Leu Pro Gly Gly Ser Val Pro Thr Val Ala Val Phe Met Leu
            500                 505                 510         
Lys Ile Phe Met Ser Leu Val Val Gly Ile Thr Ser Gly Val Trp Val
        515                 520                 525             
Trp Ser Ser Lys Thr Phe Gln Thr Trp Gln Ser Leu Cys Tyr Arg Lys
    530                 535                 540                 
Ile Ala Ala Gly Arg Ala Arg Ala Lys Ala Cys Arg Ala Pro Gly Ser
545                 550                 555                 560 
Tyr Gly Arg Gly Thr His Cys His Tyr Lys Ala Pro Thr Val Val Leu
                565                 570                 575     
His Met Thr Lys Thr Asp Pro Ser Leu Glu Asn Pro Thr His Leu
            580                 585                 590     


<210> 424
<211> 785
<212> PRT
<213> Homo sapiens

<400> 424
Met Val Val Pro Ser Leu Lys Leu Gln Asp Leu Ile Glu Glu Ile Arg
 1               5                  10                  15      
Gly Ala Lys Thr Gln Ala Gln Glu Arg Glu Val Ile Gln Lys Glu Cys
            20                  25                  30          
Ala His Ile Arg Ala Ser Phe Arg Asp Gly Asp Pro Val His Arg His
        35                  40                  45              
Arg Gln Leu Ala Lys Leu Leu Tyr Val His Met Leu Gly Tyr Pro Ala
    50                  55                  60                  
His Phe Gly Gln Met Glu Cys Leu Lys Leu Ile Ala Ser Ser Arg Phe
65                  70                  75                  80  
Thr Asp Lys Arg Val Gly Tyr Leu Gly Ala Met Leu Leu Leu Asp Glu
                85                  90                  95      
Arg His Asp Ala His Leu Leu Ile Thr Asn Ser Ile Lys Asn Asp Leu
            100                 105                 110         
Ser Gln Gly Ile Gln Pro Val Gln Gly Leu Ala Leu Cys Thr Leu Ser
        115                 120                 125             
Thr Met Gly Ser Ala Glu Met Cys Arg Asp Leu Ala Pro Glu Val Glu
    130                 135                 140                 
Lys Leu Leu Leu Gln Pro Ser Pro Tyr Val Arg Lys Lys Ala Ile Leu
145                 150                 155                 160 
Thr Ala Val His Met Ile Arg Lys Val Pro Glu Leu Ser Ser Val Phe
                165                 170                 175     
Leu Pro Pro Cys Ala Gln Leu Leu His Glu Arg His His Gly Ile Leu
            180                 185                 190         
Leu Gly Thr Ile Thr Leu Ile Thr Glu Leu Cys Glu Arg Ser Pro Ala
        195                 200                 205             
Ala Leu Arg His Phe Arg Lys Val Val Pro Gln Leu Val His Ile Leu
    210                 215                 220                 
Arg Thr Leu Val Thr Met Gly Tyr Ser Thr Glu His Ser Ile Ser Gly
225                 230                 235                 240 
Val Ser Asp Pro Phe Leu Gln Val Gln Ile Leu Arg Leu Leu Arg Ile
                245                 250                 255     
Leu Gly Arg Asn His Glu Glu Ser Ser Glu Thr Met Asn Asp Leu Leu
            260                 265                 270         
Ala Gln Val Ala Thr Asn Thr Asp Thr Ser Arg Asn Ala Gly Asn Ala
        275                 280                 285             
Val Leu Phe Glu Thr Val Leu Thr Ile Met Asp Ile Arg Ser Ala Ala
    290                 295                 300                 
Gly Leu Arg Val Leu Ala Val Asn Ile Leu Gly Arg Phe Leu Leu Asn
305                 310                 315                 320 
Ser Asp Arg Asn Ile Arg Tyr Val Ala Leu Thr Ser Leu Leu Arg Leu
                325                 330                 335     
Val Gln Ser Asp His Ser Ala Val Gln Arg His Arg Pro Thr Val Val
            340                 345                 350         
Glu Cys Leu Arg Glu Thr Asp Ala Ser Leu Ser Arg Arg Ala Leu Glu
        355                 360                 365             
Leu Ser Leu Ala Leu Val Asn Ser Ser Asn Val Arg Ala Met Met Gln
    370                 375                 380                 
Glu Leu Gln Ala Phe Leu Glu Ser Cys Pro Pro Asp Leu Arg Ala Asp
385                 390                 395                 400 
Cys Ala Ser Gly Ile Leu Leu Ala Ala Glu Arg Phe Ala Pro Thr Lys
                405                 410                 415     
Arg Trp His Ile Asp Thr Ile Leu His Val Leu Thr Thr Ala Gly Thr
            420                 425                 430         
His Val Arg Asp Asp Ala Val Ala Asn Leu Thr Gln Leu Ile Gly Gly
        435                 440                 445             
Ala Gln Glu Leu His Ala Tyr Ser Val Arg Arg Leu Tyr Asn Ala Leu
    450                 455                 460                 
Ala Glu Asp Ile Ser Gln Gln Pro Leu Val Gln Val Ala Ala Trp Cys
465                 470                 475                 480 
Ile Gly Glu Tyr Gly Asp Leu Leu Leu Ala Gly Asn Cys Glu Glu Ile
                485                 490                 495     
Glu Pro Leu Gln Val Asp Glu Glu Glu Val Leu Ala Leu Leu Glu Lys
            500                 505                 510         
Val Leu Gln Ser His Met Ser Leu Pro Ala Thr Arg Gly Tyr Ala Leu
        515                 520                 525             
Thr Ala Leu Met Lys Leu Ser Thr Arg Leu Cys Gly Asp Asn Asn Arg
    530                 535                 540                 
Ile Arg Gln Val Val Ser Ile Tyr Gly Ser Cys Leu Asp Val Glu Leu
545                 550                 555                 560 
Gln Gln Arg Ala Val Glu Tyr Asp Thr Leu Phe Arg Lys Tyr Asp His
                565                 570                 575     
Met Arg Ala Ala Ile Leu Glu Lys Met Pro Leu Val Glu Arg Asp Gly
            580                 585                 590         
Pro Gln Ala Asp Glu Glu Ala Lys Glu Ser Lys Glu Ala Ala Gln Leu
        595                 600                 605             
Ser Glu Ala Ala Pro Val Pro Thr Glu Pro Gln Ala Ser Gln Leu Leu
    610                 615                 620                 
Asp Leu Leu Asp Leu Leu Asp Gly Ala Ser Gly Asp Val Gln His Pro
625                 630                 635                 640 
Pro His Leu Asp Pro Ser Pro Gly Gly Ala Leu Val His Leu Leu Asp
                645                 650                 655     
Leu Pro Cys Val Pro Pro Pro Pro Ala Pro Ile Pro Asp Leu Lys Val
            660                 665                 670         
Phe Glu Arg Glu Gly Val Gln Leu Asn Leu Ser Phe Ile Arg Pro Pro
        675                 680                 685             
Glu Asn Pro Ala Leu Leu Leu Ile Thr Ile Thr Ala Thr Asn Phe Ser
    690                 695                 700                 
Glu Gly Asp Val Thr His Phe Ile Cys Gln Ala Ala Val Pro Lys Ser
705                 710                 715                 720 
Leu Gln Leu Gln Leu Gln Ala Pro Ser Gly Asn Thr Val Pro Ala Arg
                725                 730                 735     
Gly Gly Leu Pro Ile Thr Gln Leu Phe Arg Ile Leu Asn Pro Asn Lys
            740                 745                 750         
Ala Pro Leu Arg Leu Lys Leu Arg Leu Thr Tyr Asp His Phe His Gln
        755                 760                 765             
Ser Val Gln Glu Ile Phe Glu Val Asn Asn Leu Pro Val Glu Ser Trp
    770                 775                 780                 
Gln
785 


<210> 425
<211> 522
<212> PRT
<213> Homo sapiens

<400> 425
Met Ala Ala Val Val Ala Ala Thr Arg Trp Trp Gln Leu Leu Leu Val
 1               5                  10                  15      
Leu Ser Ala Ala Gly Met Gly Ala Ser Gly Ala Pro Gln Pro Pro Asn
            20                  25                  30          
Ile Leu Leu Leu Leu Met Asp Asp Met Gly Trp Gly Asp Leu Gly Val
        35                  40                  45              
Tyr Gly Glu Pro Ser Arg Glu Thr Pro Asn Leu Asp Arg Met Ala Ala
    50                  55                  60                  
Glu Gly Leu Leu Phe Pro Asn Phe Tyr Ser Ala Asn Pro Leu Cys Ser
65                  70                  75                  80  
Pro Ser Arg Ala Ala Leu Leu Thr Gly Arg Leu Pro Ile Arg Asn Gly
                85                  90                  95      
Phe Tyr Thr Thr Asn Ala His Ala Arg Asn Ala Tyr Thr Pro Gln Glu
            100                 105                 110         
Ile Val Gly Gly Ile Pro Asp Ser Glu Gln Leu Leu Pro Glu Leu Leu
        115                 120                 125             
Lys Lys Ala Gly Tyr Val Ser Lys Ile Val Gly Lys Trp His Leu Gly
    130                 135                 140                 
His Arg Pro Gln Phe His Pro Leu Lys His Gly Phe Asp Glu Trp Phe
145                 150                 155                 160 
Gly Ser Pro Asn Cys His Phe Gly Pro Tyr Asp Asn Lys Ala Arg Pro
                165                 170                 175     
Asn Ile Pro Val Tyr Arg Asp Trp Glu Met Val Gly Arg Tyr Tyr Glu
            180                 185                 190         
Glu Phe Pro Ile Asn Leu Lys Thr Gly Glu Ala Asn Leu Thr Gln Ile
        195                 200                 205             
Tyr Leu Gln Glu Ala Leu Asp Phe Ile Lys Arg Gln Ala Arg His His
    210                 215                 220                 
Pro Phe Phe Leu Tyr Trp Ala Val Asp Ala Thr His Ala Pro Val Tyr
225                 230                 235                 240 
Ala Ser Lys Pro Phe Leu Gly Thr Ser Gln Arg Gly Arg Tyr Gly Asp
                245                 250                 255     
Ala Val Arg Glu Ile Asp Asp Ser Ile Gly Lys Ile Leu Glu Leu Leu
            260                 265                 270         
Gln Asp Leu His Val Ala Asp Asn Thr Phe Val Phe Phe Thr Ser Asp
        275                 280                 285             
Asn Gly Ala Ala Leu Ile Ser Ala Pro Glu Gln Gly Gly Ser Asn Gly
    290                 295                 300                 
Pro Phe Leu Cys Gly Lys Gln Thr Thr Phe Glu Gly Gly Met Arg Glu
305                 310                 315                 320 
Pro Ala Leu Ala Trp Trp Pro Gly His Val Thr Ala Gly Gln Val Ser
                325                 330                 335     
His Gln Leu Gly Ser Ile Met Asp Leu Phe Thr Thr Ser Leu Ala Leu
            340                 345                 350         
Ala Gly Leu Thr Pro Pro Ser Asp Arg Ala Ile Asp Gly Leu Asn Leu
        355                 360                 365             
Leu Pro Thr Leu Leu Gln Gly Arg Leu Met Asp Arg Pro Ile Phe Tyr
    370                 375                 380                 
Tyr Arg Gly Asp Thr Leu Met Ala Ala Thr Leu Gly Gln His Lys Ala
385                 390                 395                 400 
His Phe Trp Thr Trp Thr Asn Ser Trp Glu Asn Phe Arg Gln Gly Ile
                405                 410                 415     
Asp Phe Cys Pro Gly Gln Asn Val Ser Gly Val Thr Thr His Asn Leu
            420                 425                 430         
Glu Asp His Thr Lys Leu Pro Leu Ile Phe His Leu Gly Arg Asp Pro
        435                 440                 445             
Gly Glu Arg Phe Pro Leu Ser Phe Ala Ser Ala Glu Tyr Gln Glu Ala
    450                 455                 460                 
Leu Ser Arg Ile Thr Ser Val Val Gln Gln His Gln Glu Ala Leu Val
465                 470                 475                 480 
Pro Ala Gln Pro Gln Leu Asn Val Cys Asn Trp Ala Val Met Asn Trp
                485                 490                 495     
Ala Pro Pro Gly Cys Glu Lys Leu Gly Lys Cys Leu Thr Pro Pro Glu
            500                 505                 510         
Ser Ile Pro Lys Lys Cys Leu Trp Ser His
        515                 520         


<210> 426
<211> 286
<212> PRT
<213> Homo sapiens

<400> 426
Met Ala Ala Arg Val Leu Arg Ala Arg Gly Ala Ala Trp Ala Gly Gly
 1               5                  10                  15      
Leu Leu Gln Arg Ala Ala Pro Cys Ser Leu Leu Pro Arg Leu Arg Thr
            20                  25                  30          
Trp Thr Ser Ser Ser Asn Arg Ser Arg Glu Asp Ser Trp Leu Lys Ser
        35                  40                  45              
Leu Phe Val Arg Lys Val Asp Pro Arg Lys Asp Ala His Ser Asn Leu
    50                  55                  60                  
Leu Ala Lys Lys Glu Thr Ser Asn Leu Tyr Lys Leu Gln Phe His Asn
65                  70                  75                  80  
Val Lys Pro Glu Cys Leu Glu Ala Tyr Asn Lys Ile Cys Gln Glu Val
                85                  90                  95      
Leu Pro Lys Ile His Glu Asp Lys His Tyr Pro Cys Thr Leu Val Gly
            100                 105                 110         
Thr Trp Asn Thr Trp Tyr Gly Glu Gln Asp Gln Ala Val His Leu Trp
        115                 120                 125             
Arg Tyr Glu Gly Gly Tyr Pro Ala Leu Thr Glu Val Met Asn Lys Leu
    130                 135                 140                 
Arg Glu Asn Lys Glu Phe Leu Glu Phe Arg Lys Ala Arg Ser Asp Met
145                 150                 155                 160 
Leu Leu Ser Arg Lys Asn Gln Leu Leu Leu Glu Phe Ser Phe Trp Asn
                165                 170                 175     
Glu Pro Val Pro Arg Ser Gly Pro Asn Ile Tyr Glu Leu Arg Ser Tyr
            180                 185                 190         
Gln Leu Arg Pro Gly Thr Met Ile Glu Trp Gly Asn Tyr Trp Ala Arg
        195                 200                 205             
Ala Ile Arg Phe Arg Gln Asp Gly Asn Glu Ala Val Gly Gly Phe Phe
    210                 215                 220                 
Ser Gln Ile Gly Gln Leu Tyr Met Val His His Leu Trp Ala Tyr Arg
225                 230                 235                 240 
Asp Leu Gln Thr Arg Glu Asp Ile Arg Asn Ala Ala Trp His Lys His
                245                 250                 255     
Gly Trp Glu Glu Leu Val Tyr Tyr Thr Val Pro Leu Ile Gln Glu Met
            260                 265                 270         
Glu Ser Arg Ile Met Ile Pro Leu Lys Thr Ser Pro Leu Gln
        275                 280                 285     


<210> 427
<211> 355
<212> PRT
<213> Homo sapiens

<400> 427
Met Gly Cys Thr Val Ser Ala Glu Asp Lys Ala Ala Ala Glu Arg Ser
 1               5                  10                  15      
Lys Met Ile Asp Lys Asn Leu Arg Glu Asp Gly Glu Lys Ala Ala Arg
            20                  25                  30          
Glu Val Lys Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr
        35                  40                  45              
Ile Val Lys Gln Met Lys Ile Ile His Glu Asp Gly Tyr Ser Glu Glu
    50                  55                  60                  
Glu Cys Arg Gln Tyr Arg Ala Val Val Tyr Ser Asn Thr Ile Gln Ser
65                  70                  75                  80  
Ile Met Ala Ile Val Lys Ala Met Gly Asn Leu Gln Ile Asp Phe Ala
                85                  90                  95      
Asp Pro Ser Arg Ala Asp Asp Ala Arg Gln Leu Phe Ala Leu Ser Cys
            100                 105                 110         
Thr Ala Glu Glu Gln Gly Val Leu Pro Asp Asp Leu Ser Gly Val Ile
        115                 120                 125             
Arg Arg Leu Trp Ala Asp His Gly Val Gln Ala Cys Phe Gly Arg Ser
    130                 135                 140                 
Arg Glu Tyr Gln Leu Asn Asp Ser Ala Ala Tyr Tyr Leu Asn Asp Leu
145                 150                 155                 160 
Glu Arg Ile Ala Gln Ser Asp Tyr Ile Pro Thr Gln Gln Asp Val Leu
                165                 170                 175     
Arg Thr Arg Val Lys Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe
            180                 185                 190         
Lys Asp Leu His Phe Lys Met Phe Asp Val Gly Gly Gln Arg Ser Glu
        195                 200                 205             
Arg Lys Lys Trp Ile His Cys Phe Glu Gly Val Thr Ala Ile Ile Phe
    210                 215                 220                 
Cys Val Ala Leu Ser Ala Tyr Asp Leu Val Leu Ala Glu Asp Glu Glu
225                 230                 235                 240 
Met Asn Arg Met His Glu Ser Met Lys Leu Phe Asp Ser Ile Cys Asn
                245                 250                 255     
Asn Lys Trp Phe Thr Asp Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys
            260                 265                 270         
Asp Leu Phe Glu Glu Lys Ile Thr His Ser Pro Leu Thr Ile Cys Phe
        275                 280                 285             
Pro Glu Tyr Thr Gly Ala Asn Lys Tyr Asp Glu Ala Ala Ser Tyr Ile
    290                 295                 300                 
Gln Ser Lys Phe Glu Asp Leu Asn Lys Arg Lys Asp Thr Lys Glu Ile
305                 310                 315                 320 
Tyr Thr His Phe Thr Cys Ala Thr Asp Thr Lys Asn Val Gln Phe Val
                325                 330                 335     
Phe Asp Ala Val Thr Asp Val Ile Ile Lys Asn Asn Leu Lys Asp Cys
            340                 345                 350         
Gly Leu Phe
        355 


<210> 428
<211> 350
<212> PRT
<213> Homo sapiens

<400> 428
Met Gly Ala Gly Ala Ser Ala Glu Glu Lys His Ser Arg Glu Leu Glu
 1               5                  10                  15      
Lys Lys Leu Lys Glu Asp Ala Glu Lys Asp Ala Arg Thr Val Lys Leu
            20                  25                  30          
Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln
        35                  40                  45              
Met Lys Ile Ile His Gln Asp Gly Tyr Ser Leu Glu Glu Cys Leu Glu
    50                  55                  60                  
Phe Ile Ala Ile Ile Tyr Gly Asn Thr Leu Gln Ser Ile Leu Ala Ile
65                  70                  75                  80  
Val Arg Ala Met Thr Thr Leu Asn Ile Gln Tyr Gly Asp Ser Ala Arg
                85                  90                  95      
Gln Asp Asp Ala Arg Lys Leu Met His Met Ala Asp Thr Ile Glu Glu
            100                 105                 110         
Gly Thr Met Pro Lys Glu Met Ser Asp Ile Ile Gln Arg Leu Trp Lys
        115                 120                 125             
Asp Ser Gly Ile Gln Ala Cys Phe Glu Arg Ala Ser Glu Tyr Gln Leu
    130                 135                 140                 
Asn Asp Ser Ala Gly Tyr Tyr Leu Ser Asp Leu Glu Arg Leu Val Thr
145                 150                 155                 160 
Pro Gly Tyr Val Pro Thr Glu Gln Asp Val Leu Arg Ser Arg Val Lys
                165                 170                 175     
Thr Thr Gly Ile Ile Glu Thr Gln Phe Ser Phe Lys Asp Leu Asn Phe
            180                 185                 190         
Arg Met Phe Asp Val Gly Gly Gln Arg Ser Glu Pro Lys Lys Trp Ile
        195                 200                 205             
His Cys Phe Glu Gly Val Thr Cys Ile Ile Phe Ile Ala Ala Leu Thr
    210                 215                 220                 
Ala Tyr Asp Met Val Leu Val Glu Asp Asp Glu Val Asn Arg Met His
225                 230                 235                 240 
Glu Ser Leu His Leu Phe Asn Ser Ile Cys Asn His Arg Tyr Phe Ala
                245                 250                 255     
Thr Thr Ser Ile Val Leu Phe Leu Asn Lys Lys Asp Val Phe Phe Glu
            260                 265                 270         
Lys Val Lys Lys Ala His Leu Ser Ile Cys Phe Pro Asp Tyr Asp Gly
        275                 280                 285             
Pro Asn Thr Tyr Glu Asp Ala Gly Asn Tyr Ile Lys Val Gln Phe Leu
    290                 295                 300                 
Glu Leu Asn Met Arg Arg Asp Val Lys Glu Ile Tyr Ser His Met Thr
305                 310                 315                 320 
Cys Ala Thr Asp Thr Gln Asn Val Lys Phe Cys Phe Asp Ala Val Thr
                325                 330                 335     
Asp Ile Ile Ile Lys Glu Asn Leu Lys Asp Cys Gly Leu Phe
            340                 345                 350 


<210> 429
<211> 413
<212> PRT
<213> Homo sapiens

<400> 429
Met Ala Pro Pro Ser Val Phe Ala Glu Val Pro Gln Ala Gln Pro Val
 1               5                  10                  15      
Leu Val Phe Lys Leu Thr Ala Asp Phe Arg Glu Asp Pro Asp Pro Arg
            20                  25                  30          
Lys Val Asn Leu Gly Val Gly Ala Tyr Arg Thr Asp Asp Cys His Pro
        35                  40                  45              
Trp Val Leu Pro Val Val Lys Lys Val Glu Gln Lys Ile Ala Asn Asp
    50                  55                  60                  
Asn Ser Leu Asn His Glu Tyr Leu Pro Ile Leu Gly Leu Ala Glu Phe
65                  70                  75                  80  
Arg Ser Cys Ala Ser Arg Leu Ala Leu Gly Asp Asp Ser Pro Ala Leu
                85                  90                  95      
Lys Glu Lys Arg Val Gly Gly Val Gln Ser Leu Gly Gly Thr Gly Ala
            100                 105                 110         
Leu Arg Ile Gly Ala Asp Phe Leu Ala Arg Trp Tyr Asn Gly Thr Asn
        115                 120                 125             
Asn Lys Asn Thr Pro Val Tyr Val Ser Ser Pro Thr Trp Glu Asn His
    130                 135                 140                 
Asn Ala Val Phe Ser Ala Ala Gly Phe Lys Asp Ile Arg Ser Tyr Arg
145                 150                 155                 160 
Tyr Trp Asp Ala Glu Lys Arg Gly Leu Asp Leu Gln Gly Phe Leu Asn
                165                 170                 175     
Asp Leu Glu Asn Ala Pro Glu Phe Ser Ile Val Val Leu His Ala Cys
            180                 185                 190         
Ala His Asn Pro Thr Gly Ile Asp Pro Thr Pro Glu Gln Trp Lys Gln
        195                 200                 205             
Ile Ala Ser Val Met Lys His Arg Phe Leu Phe Pro Phe Phe Asp Ser
    210                 215                 220                 
Ala Tyr Gln Gly Phe Ala Ser Gly Asn Leu Glu Arg Asp Ala Trp Ala
225                 230                 235                 240 
Ile Arg Tyr Phe Val Ser Glu Gly Phe Glu Phe Phe Cys Ala Gln Ser
                245                 250                 255     
Phe Ser Lys Asn Phe Gly Leu Tyr Asn Glu Arg Val Gly Asn Leu Thr
            260                 265                 270         
Val Val Gly Lys Glu Pro Glu Ser Ile Leu Gln Val Leu Ser Gln Met
        275                 280                 285             
Glu Lys Ile Val Arg Ile Thr Trp Ser Asn Pro Pro Ala Gln Gly Ala
    290                 295                 300                 
Arg Ile Val Ala Ser Thr Leu Ser Asn Pro Glu Leu Phe Glu Glu Trp
305                 310                 315                 320 
Thr Gly Asn Val Lys Thr Met Ala Asp Arg Ile Leu Thr Met Arg Ser
                325                 330                 335     
Glu Leu Arg Ala Arg Leu Glu Ala Leu Lys Thr Pro Gly Thr Trp Asn
            340                 345                 350         
His Ile Thr Asp Gln Ile Gly Met Phe Ser Phe Thr Gly Leu Asn Pro
        355                 360                 365             
Lys Gln Val Glu Tyr Leu Val Asn Glu Lys His Ile Tyr Leu Leu Pro
    370                 375                 380                 
Ser Gly Arg Ile Asn Val Ser Gly Leu Thr Thr Lys Asn Leu Asp Tyr
385                 390                 395                 400 
Val Ala Thr Ser Ile His Glu Ala Val Thr Lys Ile Gln
                405                 410             


<210> 430
<211> 626
<212> PRT
<213> Homo sapiens

<400> 430
Met Pro Leu Leu Leu Leu Leu Leu Leu Leu Pro Ser Pro Leu His Pro
 1               5                  10                  15      
His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu Val Asn
            20                  25                  30          
Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro Lys Asp
        35                  40                  45              
Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe Ser Leu
    50                  55                  60                  
Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu Asp Arg
65                  70                  75                  80  
Cys Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val Leu Gly
                85                  90                  95      
Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu Leu Gly
            100                 105                 110         
Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn Arg Leu
        115                 120                 125             
Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu Gln Glu
    130                 135                 140                 
Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly Leu Leu
145                 150                 155                 160 
Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn Asn Leu
                165                 170                 175     
Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu Asp Thr
            180                 185                 190         
Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly Phe Phe
        195                 200                 205             
Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro Trp Leu
    210                 215                 220                 
Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp Asn Ala
225                 230                 235                 240 
Glu Asn Val Tyr Val Trp Lys Gln Gly Val Asp Val Lys Ala Met Thr
                245                 250                 255     
Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp Lys Phe Pro Val
            260                 265                 270         
Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly Asp Glu Gly Asp
        275                 280                 285             
Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr Glu Gly Asp Lys
    290                 295                 300                 
Val Arg Ala Thr Arg Thr Val Val Lys Phe Pro Thr Lys Ala His Thr
305                 310                 315                 320 
Thr Pro Trp Gly Leu Phe Tyr Ser Trp Ser Thr Ala Ser Leu Asp Ser
                325                 330                 335     
Gln Met Pro Ser Ser Leu His Pro Thr Gln Glu Ser Thr Lys Glu Gln
            340                 345                 350         
Thr Thr Phe Pro Pro Arg Trp Thr Pro Asn Phe Thr Leu His Met Glu
        355                 360                 365             
Ser Ile Thr Phe Ser Lys Thr Pro Lys Ser Thr Thr Glu Pro Thr Pro
    370                 375                 380                 
Ser Pro Thr Thr Ser Glu Pro Val Pro Glu Pro Ala Pro Asn Met Thr
385                 390                 395                 400 
Thr Leu Glu Pro Thr Pro Ser Pro Thr Thr Pro Glu Pro Thr Ser Glu
                405                 410                 415     
Pro Ala Pro Ser Pro Thr Thr Pro Glu Pro Thr Pro Ile Pro Thr Ile
            420                 425                 430         
Ala Thr Ser Pro Thr Ile Leu Val Ser Ala Thr Ser Leu Ile Thr Pro
        435                 440                 445             
Lys Ser Thr Phe Leu Thr Thr Thr Lys Pro Val Ser Leu Leu Glu Ser
    450                 455                 460                 
Thr Lys Lys Thr Ile Pro Glu Leu Asp Gln Pro Pro Lys Leu Arg Gly
465                 470                 475                 480 
Val Leu Gln Gly His Leu Glu Ser Ser Arg Asn Asp Pro Phe Leu His
                485                 490                 495     
Pro Asp Phe Cys Cys Leu Leu Pro Leu Gly Phe Tyr Val Leu Gly Leu
            500                 505                 510         
Phe Trp Leu Leu Phe Ala Ser Val Val Leu Ile Leu Leu Leu Ser Trp
        515                 520                 525             
Val Gly His Val Lys Pro Gln Ala Leu Asp Ser Gly Gln Gly Ala Ala
    530                 535                 540                 
Leu Thr Thr Ala Thr Gln Thr Thr His Leu Glu Leu Gln Arg Gly Arg
545                 550                 555                 560 
Gln Val Thr Val Pro Arg Ala Trp Leu Leu Phe Leu Arg Gly Ser Leu
                565                 570                 575     
Pro Thr Phe Arg Ser Ser Leu Phe Leu Trp Val Arg Pro Asn Gly Arg
            580                 585                 590         
Val Gly Pro Leu Val Ala Gly Arg Arg Pro Ser Ala Leu Ser Gln Gly
        595                 600                 605             
Arg Gly Gln Asp Leu Leu Ser Thr Val Ser Ile Arg Tyr Ser Gly His
    610                 615                 620                 
Ser Leu
625     


<210> 431
<211> 474
<212> PRT
<213> Homo sapiens

<400> 431
Met Ala Thr Asn Trp Gly Ser Leu Leu Gln Asp Lys Gln Gln Leu Glu
 1               5                  10                  15      
Glu Leu Ala Arg Gln Ala Val Asp Arg Ala Leu Ala Glu Gly Val Leu
            20                  25                  30          
Leu Arg Thr Ser Gln Glu Pro Thr Ser Ser Glu Val Val Ser Tyr Ala
        35                  40                  45              
Pro Phe Thr Leu Phe Pro Ser Leu Val Pro Ser Ala Leu Leu Glu Gln
    50                  55                  60                  
Ala Tyr Ala Val Gln Met Asp Phe Asn Leu Leu Val Asp Ala Val Ser
65                  70                  75                  80  
Gln Asn Ala Ala Phe Leu Glu Gln Thr Leu Ser Ser Thr Ile Lys Gln
                85                  90                  95      
Asp Asp Phe Thr Ala Arg Leu Phe Asp Ile His Lys Gln Val Leu Lys
            100                 105                 110         
Glu Gly Ile Ala Gln Thr Val Phe Leu Gly Leu Asn Arg Ser Asp Tyr
        115                 120                 125             
Met Phe Gln Arg Ser Ala Asp Gly Ser Pro Ala Leu Lys Gln Ile Glu
    130                 135                 140                 
Ile Asn Thr Ile Ser Ala Ser Phe Gly Gly Leu Ala Ser Arg Thr Pro
145                 150                 155                 160 
Ala Val His Arg His Val Leu Ser Val Leu Ser Lys Thr Lys Glu Ala
                165                 170                 175     
Gly Lys Ile Leu Ser Asn Asn Pro Ser Lys Gly Leu Ala Leu Gly Ile
            180                 185                 190         
Ala Lys Ala Trp Glu Leu Tyr Gly Ser Pro Asn Ala Leu Val Leu Leu
        195                 200                 205             
Ile Ala Gln Glu Lys Glu Arg Asn Ile Phe Asp Gln Arg Ala Ile Glu
    210                 215                 220                 
Asn Glu Leu Leu Ala Arg Asn Ile His Val Ile Arg Arg Thr Phe Glu
225                 230                 235                 240 
Asp Ile Ser Glu Lys Gly Ser Leu Asp Gln Asp Arg Arg Leu Phe Val
                245                 250                 255     
Asp Gly Gln Glu Ile Ala Val Val Tyr Phe Arg Asp Gly Tyr Met Pro
            260                 265                 270         
Arg Gln Tyr Ser Leu Gln Asn Trp Glu Ala Arg Leu Leu Leu Glu Arg
        275                 280                 285             
Ser His Ala Ala Lys Cys Pro Asp Ile Ala Thr Gln Leu Ala Gly Thr
    290                 295                 300                 
Lys Lys Val Gln Gln Glu Leu Ser Arg Pro Gly Met Leu Glu Met Leu
305                 310                 315                 320 
Leu Pro Gly Gln Pro Glu Ala Val Ala Arg Leu Arg Ala Thr Phe Ala
                325                 330                 335     
Gly Leu Tyr Ser Leu Asp Val Gly Glu Glu Gly Asp Gln Ala Ile Ala
            340                 345                 350         
Glu Ala Leu Ala Ala Pro Ser Arg Phe Val Leu Lys Pro Gln Arg Glu
        355                 360                 365             
Gly Gly Gly Asn Asn Leu Tyr Gly Glu Glu Met Val Gln Ala Leu Lys
    370                 375                 380                 
Gln Leu Lys Asp Ser Glu Glu Arg Ala Ser Tyr Ile Leu Met Glu Lys
385                 390                 395                 400 
Ile Glu Pro Glu Pro Phe Glu Asn Cys Leu Leu Arg Pro Gly Ser Pro
                405                 410                 415     
Ala Arg Val Val Gln Cys Ile Ser Glu Leu Gly Ile Phe Gly Val Tyr
            420                 425                 430         
Val Arg Gln Glu Lys Thr Leu Val Met Asn Lys His Val Gly His Leu
        435                 440                 445             
Leu Arg Thr Lys Ala Ile Glu His Ala Asp Gly Gly Val Ala Ala Gly
    450                 455                 460                 
Val Ala Val Leu Asp Asn Pro Tyr Pro Val
465                 470                 


<210> 432
<211> 216
<212> PRT
<213> Homo sapiens

<400> 432
Met Gln Ala Gly Lys Pro Ile Leu Tyr Ser Tyr Phe Arg Ser Ser Cys
 1               5                  10                  15      
Ser Trp Arg Val Arg Ile Ala Leu Ala Leu Lys Gly Ile Asp Tyr Lys
            20                  25                  30          
Thr Val Pro Ile Asn Leu Ile Lys Asp Arg Gly Gln Gln Phe Ser Lys
        35                  40                  45              
Asp Phe Gln Ala Leu Asn Pro Met Lys Gln Val Pro Thr Leu Lys Ile
    50                  55                  60                  
Asp Gly Ile Thr Ile His Gln Ser Leu Ala Ile Ile Glu Tyr Leu Glu
65                  70                  75                  80  
Glu Thr Arg Pro Thr Pro Arg Leu Leu Pro Gln Asp Pro Lys Lys Arg
                85                  90                  95      
Ala Ser Val Arg Met Ile Ser Asp Leu Ile Ala Gly Gly Ile Gln Pro
            100                 105                 110         
Leu Gln Asn Leu Ser Val Leu Lys Gln Val Gly Glu Glu Met Gln Leu
        115                 120                 125             
Thr Trp Ala Gln Asn Ala Ile Thr Cys Gly Phe Asn Ala Leu Glu Gln
    130                 135                 140                 
Ile Leu Gln Ser Thr Ala Gly Ile Tyr Cys Val Gly Asp Glu Val Thr
145                 150                 155                 160 
Met Ala Asp Leu Cys Leu Val Pro Gln Val Ala Asn Ala Glu Arg Phe
                165                 170                 175     
Lys Val Asp Leu Thr Pro Tyr Pro Thr Ile Ser Ser Ile Asn Lys Arg
            180                 185                 190         
Leu Leu Val Leu Glu Ala Phe Gln Val Ser His Pro Cys Arg Gln Pro
        195                 200                 205             
Asp Thr Pro Thr Glu Leu Arg Ala
    210                 215     


<210> 433
<211> 218
<212> PRT
<213> Homo sapiens

<400> 433
Met Ala Thr Arg Ser Pro Gly Val Val Ile Ser Asp Asp Glu Pro Gly
 1               5                  10                  15      
Tyr Asp Leu Asp Leu Phe Cys Ile Pro Asn His Tyr Ala Glu Asp Leu
            20                  25                  30          
Glu Arg Val Phe Ile Pro His Gly Leu Ile Met Asp Arg Thr Glu Arg
        35                  40                  45              
Leu Ala Arg Asp Val Met Lys Glu Met Gly Gly His His Ile Val Ala
    50                  55                  60                  
Leu Cys Val Leu Lys Gly Gly Tyr Lys Phe Phe Ala Asp Leu Leu Asp
65                  70                  75                  80  
Tyr Ile Lys Ala Leu Asn Arg Asn Ser Asp Arg Ser Ile Pro Met Thr
                85                  90                  95      
Val Asp Phe Ile Arg Leu Lys Ser Tyr Cys Asn Asp Gln Ser Thr Gly
            100                 105                 110         
Asp Ile Lys Val Ile Gly Gly Asp Asp Leu Ser Thr Leu Thr Gly Lys
        115                 120                 125             
Asn Val Leu Ile Val Glu Asp Ile Ile Asp Thr Gly Lys Thr Met Gln
    130                 135                 140                 
Thr Leu Leu Ser Leu Val Arg Gln Tyr Asn Pro Lys Met Val Lys Val
145                 150                 155                 160 
Ala Ser Leu Leu Val Lys Arg Thr Pro Arg Ser Val Gly Tyr Lys Pro
                165                 170                 175     
Asp Phe Val Gly Phe Glu Ile Pro Asp Lys Phe Val Val Gly Tyr Ala
            180                 185                 190         
Leu Asp Tyr Asn Glu Tyr Phe Arg Asp Leu Asn His Val Cys Val Ile
        195                 200                 205             
Ser Glu Thr Gly Lys Ala Lys Tyr Lys Ala
    210                 215             


<210> 434
<211> 699
<212> PRT
<213> Homo sapiens

<400> 434
Met Gly His His Arg Pro Trp Leu His Ala Ser Val Leu Trp Ala Gly
 1               5                  10                  15      
Val Ala Ser Leu Leu Leu Pro Pro Ala Met Thr Gln Gln Leu Arg Gly
            20                  25                  30          
Asp Gly Leu Gly Phe Arg Asn Arg Asn Asn Ser Thr Gly Val Ala Gly
        35                  40                  45              
Leu Ser Glu Glu Ala Ser Ala Glu Leu Arg His His Leu His Ser Pro
    50                  55                  60                  
Arg Asp His Pro Asp Glu Asn Lys Asp Val Ser Thr Glu Asn Gly His
65                  70                  75                  80  
His Phe Trp Ser His Pro Asp Arg Glu Lys Glu Asp Glu Asp Val Ser
                85                  90                  95      
Lys Glu Tyr Gly His Leu Leu Pro Gly His Arg Ser Gln Asp His Lys
            100                 105                 110         
Val Gly Asp Glu Gly Val Ser Gly Glu Glu Val Phe Ala Glu His Gly
        115                 120                 125             
Gly Gln Ala Arg Gly His Arg Gly His Gly Ser Glu Asp Thr Glu Asp
    130                 135                 140                 
Ser Ala Glu His Arg His His Leu Pro Ser His Arg Ser His Ser His
145                 150                 155                 160 
Gln Asp Glu Asp Glu Asp Glu Val Val Ser Ser Glu His His His His
                165                 170                 175     
Ile Leu Arg His Gly His Arg Gly His Asp Gly Glu Asp Asp Glu Gly
            180                 185                 190         
Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Ala Ser Thr Glu
        195                 200                 205             
Tyr Gly His Gln Ala His Arg His Arg Gly His Gly Ser Glu Glu Asp
    210                 215                 220                 
Glu Asp Val Ser Asp Gly His His His His Gly Pro Ser His Arg His
225                 230                 235                 240 
Gln Gly His Glu Glu Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp
                245                 250                 255     
Asp Asp Asp Asp Asp Val Ser Ile Glu Tyr Arg His Gln Ala His Arg
            260                 265                 270         
His Gln Gly His Gly Ile Glu Glu Asp Glu Asp Val Ser Asp Gly His
        275                 280                 285             
His His Arg Asp Pro Ser His Arg His Arg Ser His Glu Glu Asp Asp
    290                 295                 300                 
Asn Asp Asp Asp Asp Val Ser Thr Glu Tyr Gly His Gln Ala His Arg
305                 310                 315                 320 
His Gln Asp His Arg Lys Glu Glu Val Glu Ala Val Ser Gly Glu His
                325                 330                 335     
His His His Val Pro Asp His Arg His Gln Gly His Arg Asp Glu Glu
            340                 345                 350         
Glu Asp Glu Asp Val Ser Thr Glu Arg Trp His Gln Gly Pro Gln His
        355                 360                 365             
Val His His Gly Leu Val Asp Glu Glu Glu Glu Glu Glu Glu Ile Thr
    370                 375                 380                 
Val Gln Phe Gly His Tyr Val Ala Ser His Gln Pro Arg Gly His Lys
385                 390                 395                 400 
Ser Asp Glu Glu Asp Phe Gln Asp Glu Tyr Lys Thr Glu Val Pro His
                405                 410                 415     
His His His His Arg Val Pro Arg Glu Glu Asp Glu Glu Val Ser Ala
            420                 425                 430         
Glu Leu Gly His Gln Ala Pro Ser His Arg Gln Ser His Gln Asp Glu
        435                 440                 445             
Glu Thr Gly His Gly Gln Arg Gly Ser Ile Lys Glu Met Ser His His
    450                 455                 460                 
Pro Pro Gly His Thr Val Val Lys Asp Arg Ser His Leu Arg Lys Asp
465                 470                 475                 480 
Asp Ser Glu Glu Glu Lys Glu Lys Glu Glu Asp Pro Gly Ser His Glu
                485                 490                 495     
Glu Asp Asp Glu Ser Ser Glu Gln Gly Glu Lys Gly Thr His His Gly
            500                 505                 510         
Ser Arg Asp Gln Glu Asp Glu Glu Asp Glu Glu Glu Gly His Gly Leu
        515                 520                 525             
Ser Leu Asn Gln Glu Glu Glu Glu Glu Glu Asp Lys Glu Glu Glu Glu
    530                 535                 540                 
Glu Glu Glu Asp Glu Glu Arg Arg Glu Glu Arg Ala Glu Val Gly Ala
545                 550                 555                 560 
Pro Leu Ser Pro Asp His Ser Glu Glu Glu Glu Glu Glu Glu Glu Gly
                565                 570                 575     
Leu Glu Glu Asp Glu Pro Arg Phe Thr Ile Ile Pro Asn Pro Leu Asp
            580                 585                 590         
Arg Arg Glu Glu Ala Gly Gly Ala Ser Ser Glu Glu Glu Ser Gly Glu
        595                 600                 605             
Asp Thr Gly Pro Gln Asp Ala Gln Glu Tyr Gly Asn Tyr Gln Pro Gly
    610                 615                 620                 
Ser Leu Cys Gly Tyr Cys Ser Phe Cys Asn Arg Cys Thr Glu Cys Glu
625                 630                 635                 640 
Ser Cys His Cys Asp Glu Glu Asn Met Gly Glu His Cys Asp Gln Cys
                645                 650                 655     
Gln His Cys Gln Phe Cys Tyr Leu Cys Pro Leu Val Cys Glu Thr Val
            660                 665                 670         
Cys Ala Pro Gly Ser Tyr Val Asp Tyr Phe Ser Ser Ser Leu Tyr Gln
        675                 680                 685             
Ala Leu Ala Asp Met Leu Glu Thr Pro Glu Pro
    690                 695                 


<210> 435
<211> 205
<212> PRT
<213> Homo sapiens

<400> 435
Met Thr Glu Arg Arg Val Pro Phe Ser Leu Leu Arg Gly Pro Ser Trp
 1               5                  10                  15      
Asp Pro Phe Arg Asp Trp Tyr Pro His Ser Arg Leu Phe Asp Gln Ala
            20                  25                  30          
Phe Gly Leu Pro Arg Leu Pro Glu Glu Trp Ser Gln Trp Leu Gly Gly
        35                  40                  45              
Ser Ser Trp Pro Gly Tyr Val Arg Pro Leu Pro Pro Ala Ala Ile Glu
    50                  55                  60                  
Ser Pro Ala Val Ala Ala Pro Ala Tyr Ser Arg Ala Leu Ser Arg Gln
65                  70                  75                  80  
Leu Ser Ser Gly Val Ser Glu Ile Arg His Thr Ala Asp Arg Trp Arg
                85                  90                  95      
Val Ser Leu Asp Val Asn His Phe Ala Pro Asp Glu Leu Thr Val Lys
            100                 105                 110         
Thr Lys Asp Gly Val Val Glu Ile Thr Gly Lys His Glu Glu Arg Gln
        115                 120                 125             
Asp Glu His Gly Tyr Ile Ser Arg Cys Phe Thr Arg Lys Tyr Thr Leu
    130                 135                 140                 
Pro Pro Gly Val Asp Pro Thr Gln Val Ser Ser Ser Leu Ser Pro Glu
145                 150                 155                 160 
Gly Thr Leu Thr Val Glu Ala Pro Met Pro Lys Leu Ala Thr Gln Ser
                165                 170                 175     
Asn Glu Ile Thr Ile Pro Val Thr Phe Glu Ser Arg Ala Gln Leu Gly
            180                 185                 190         
Gly Pro Glu Ala Ala Lys Ser Asp Glu Thr Ala Ala Lys
        195                 200                 205 


<210> 436
<211> 573
<212> PRT
<213> Homo sapiens

<400> 436
Met Leu Arg Leu Pro Thr Val Phe Arg Gln Met Arg Pro Val Ser Arg
 1               5                  10                  15      
Val Leu Ala Pro His Leu Thr Arg Ala Tyr Ala Lys Asp Val Lys Phe
            20                  25                  30          
Gly Ala Asp Ala Arg Ala Leu Met Leu Gln Gly Val Asp Leu Leu Ala
        35                  40                  45              
Asp Ala Val Ala Val Thr Met Gly Pro Lys Gly Arg Thr Val Ile Ile
    50                  55                  60                  
Glu Gln Gly Trp Gly Ser Pro Lys Val Thr Lys Asp Gly Val Thr Val
65                  70                  75                  80  
Ala Lys Ser Ile Asp Leu Lys Asp Lys Tyr Lys Asn Ile Gly Ala Lys
                85                  90                  95      
Leu Val Gln Asp Val Ala Asn Asn Thr Asn Glu Glu Ala Gly Asp Gly
            100                 105                 110         
Thr Thr Thr Ala Thr Val Leu Ala Arg Ser Ile Ala Lys Glu Gly Phe
        115                 120                 125             
Glu Lys Ile Ser Lys Gly Ala Asn Pro Val Glu Ile Arg Arg Gly Val
    130                 135                 140                 
Met Leu Ala Val Asp Ala Val Ile Ala Glu Leu Lys Lys Gln Ser Lys
145                 150                 155                 160 
Pro Val Thr Thr Pro Glu Glu Ile Ala Gln Val Ala Thr Ile Ser Ala
                165                 170                 175     
Asn Gly Asp Lys Glu Ile Gly Asn Ile Ile Ser Asp Ala Met Lys Lys
            180                 185                 190         
Val Gly Arg Lys Gly Val Ile Thr Val Lys Asp Gly Lys Thr Leu Asn
        195                 200                 205             
Asp Glu Leu Glu Ile Ile Glu Gly Met Lys Phe Asp Arg Gly Tyr Ile
    210                 215                 220                 
Ser Pro Tyr Phe Ile Asn Thr Ser Lys Gly Gln Lys Cys Glu Phe Gln
225                 230                 235                 240 
Asp Ala Tyr Val Leu Leu Ser Glu Lys Lys Ile Ser Ser Ile Gln Ser
                245                 250                 255     
Ile Val Pro Ala Leu Glu Ile Ala Asn Ala His Arg Lys Pro Leu Val
            260                 265                 270         
Ile Ile Ala Glu Asp Val Asp Gly Glu Ala Leu Ser Thr Leu Val Leu
        275                 280                 285             
Asn Arg Leu Lys Val Gly Leu Gln Val Val Ala Val Lys Ala Pro Gly
    290                 295                 300                 
Phe Gly Asp Asn Arg Lys Asn Gln Leu Lys Asp Met Ala Ile Ala Thr
305                 310                 315                 320 
Gly Gly Ala Val Phe Gly Glu Glu Gly Leu Thr Leu Asn Leu Glu Asp
                325                 330                 335     
Val Gln Pro His Asp Leu Gly Lys Val Gly Glu Val Ile Val Thr Lys
            340                 345                 350         
Asp Asp Ala Met Leu Leu Lys Gly Lys Gly Asp Lys Ala Gln Ile Glu
        355                 360                 365             
Lys Arg Ile Gln Glu Ile Ile Glu Gln Leu Asp Val Thr Thr Ser Glu
    370                 375                 380                 
Tyr Glu Lys Glu Lys Leu Asn Glu Arg Leu Ala Lys Leu Ser Asp Gly
385                 390                 395                 400 
Val Ala Val Leu Lys Val Gly Gly Thr Ser Asp Val Glu Val Asn Glu
                405                 410                 415     
Lys Lys Asp Arg Val Thr Asp Ala Leu Asn Ala Thr Arg Ala Ala Val
            420                 425                 430         
Glu Glu Gly Ile Val Leu Gly Gly Gly Cys Ala Leu Leu Arg Cys Ile
        435                 440                 445             
Pro Ala Leu Asp Ser Leu Thr Pro Ala Asn Glu Asp Gln Lys Ile Gly
    450                 455                 460                 
Ile Glu Ile Ile Lys Arg Thr Leu Lys Ile Pro Ala Met Thr Ile Ala
465                 470                 475                 480 
Lys Asn Ala Gly Val Glu Gly Ser Leu Ile Val Glu Lys Ile Met Gln
                485                 490                 495     
Ser Ser Ser Glu Val Gly Tyr Asp Ala Met Ala Gly Asp Phe Val Asn
            500                 505                 510         
Met Val Glu Lys Gly Ile Ile Asp Pro Thr Lys Val Val Arg Thr Ala
        515                 520                 525             
Leu Leu Asp Ala Ala Gly Val Ala Ser Leu Leu Thr Thr Ala Glu Val
    530                 535                 540                 
Val Val Thr Glu Ile Pro Lys Glu Glu Lys Asp Pro Gly Met Gly Ala
545                 550                 555                 560 
Met Gly Gly Met Gly Gly Gly Met Gly Gly Gly Met Phe
                565                 570             


<210> 437
<211> 102
<212> PRT
<213> Homo sapiens

<400> 437
Met Ala Gly Gln Ala Phe Arg Lys Phe Leu Pro Leu Phe Asp Arg Val
 1               5                  10                  15      
Leu Val Glu Arg Ser Ala Ala Glu Thr Val Thr Lys Gly Gly Ile Met
            20                  25                  30          
Leu Pro Glu Lys Ser Gln Gly Lys Val Leu Gln Ala Thr Val Val Ala
        35                  40                  45              
Val Gly Ser Gly Ser Lys Gly Lys Gly Gly Glu Ile Gln Pro Val Ser
    50                  55                  60                  
Val Lys Val Gly Asp Lys Val Leu Leu Pro Glu Tyr Gly Gly Thr Lys
65                  70                  75                  80  
Val Val Leu Asp Asp Lys Asp Tyr Phe Leu Phe Arg Asp Gly Asp Ile
                85                  90                  95      
Leu Gly Lys Tyr Val Asp
            100         


<210> 438
<211> 102
<212> PRT
<213> Homo sapiens

<400> 438
Met Ala Gly Gln Ala Phe Arg Lys Phe Leu Pro Leu Phe Asp Arg Val
 1               5                  10                  15      
Leu Val Glu Arg Ser Ala Ala Glu Thr Val Thr Lys Gly Gly Ile Met
            20                  25                  30          
Leu Pro Glu Lys Ser Gln Gly Lys Val Leu Gln Ala Thr Val Val Ala
        35                  40                  45              
Val Gly Ser Gly Ser Lys Gly Lys Gly Gly Glu Ile Gln Pro Val Ser
    50                  55                  60                  
Val Lys Val Gly Asp Lys Val Leu Leu Pro Glu Tyr Gly Gly Thr Lys
65                  70                  75                  80  
Val Val Leu Asp Asp Lys Asp Tyr Phe Leu Phe Arg Asp Gly Asp Ile
                85                  90                  95      
Leu Gly Lys Tyr Val Asp
            100         


<210> 439
<211> 551
<212> PRT
<213> Homo sapiens

<400> 439
Met Ala Ala Pro Ala Leu Ser Trp Arg Leu Pro Leu Leu Ile Leu Leu
 1               5                  10                  15      
Leu Pro Leu Ala Thr Ser Trp Ala Ser Ala Ala Val Asn Gly Thr Ser
            20                  25                  30          
Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp
        35                  40                  45              
Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp
    50                  55                  60                  
Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser
65                  70                  75                  80  
Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln
                85                  90                  95      
Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu
            100                 105                 110         
Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu
        115                 120                 125             
Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu
    130                 135                 140                 
Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr
145                 150                 155                 160 
Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His
                165                 170                 175     
Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp
            180                 185                 190         
Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val
        195                 200                 205             
Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser
    210                 215                 220                 
Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp Thr
225                 230                 235                 240 
Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly
                245                 250                 255     
Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg Asn Thr Gly Pro
            260                 265                 270         
Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe
        275                 280                 285             
Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu
    290                 295                 300                 
Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro
305                 310                 315                 320 
Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu
                325                 330                 335     
Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser Asn
            340                 345                 350         
His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His
        355                 360                 365             
Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr Phe Thr Tyr
    370                 375                 380                 
Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val Ala Gly Ala Pro
385                 390                 395                 400 
Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp
                405                 410                 415     
Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro
            420                 425                 430         
Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly Ser
        435                 440                 445             
Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln Glu Arg Val Pro
    450                 455                 460                 
Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro Gly Val Pro
465                 470                 475                 480 
Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val Leu Arg Glu Ala
                485                 490                 495     
Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly Val Ser Phe Pro
            500                 505                 510         
Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg
        515                 520                 525             
Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly
    530                 535                 540                 
Gln Asp Pro Thr His Leu Val
545                 550     


<210> 440
<211> 514
<212> PRT
<213> Homo sapiens

<400> 440
Met Ala Asp Tyr Leu Ile Ser Gly Gly Thr Ser Tyr Val Pro Asp Asp
 1               5                  10                  15      
Gly Leu Thr Ala Gln Gln Leu Phe Asn Cys Gly Asp Gly Leu Thr Tyr
            20                  25                  30          
Asn Asp Phe Leu Ile Leu Pro Gly Tyr Ile Asp Phe Thr Ala Asp Gln
        35                  40                  45              
Val Asp Leu Thr Ser Ala Leu Thr Lys Lys Ile Thr Leu Lys Thr Pro
    50                  55                  60                  
Leu Val Ser Ser Pro Met Asp Thr Val Thr Glu Ala Gly Met Ala Ile
65                  70                  75                  80  
Ala Met Ala Leu Thr Gly Gly Ile Gly Phe Ile His His Asn Cys Thr
                85                  90                  95      
Pro Glu Phe Gln Ala Asn Glu Val Arg Lys Val Lys Lys Tyr Glu Gln
            100                 105                 110         
Gly Phe Ile Thr Asp Pro Val Val Leu Ser Pro Lys Asp Arg Val Arg
        115                 120                 125             
Asp Val Phe Glu Ala Lys Ala Arg His Gly Phe Cys Gly Ile Pro Ile
    130                 135                 140                 
Thr Asp Thr Gly Arg Met Gly Ser Arg Leu Val Gly Ile Ile Ser Ser
145                 150                 155                 160 
Arg Asp Ile Asp Phe Leu Lys Glu Glu Glu His Asp Cys Phe Leu Glu
                165                 170                 175     
Glu Ile Met Thr Lys Arg Glu Asp Leu Val Val Ala Pro Arg Ser Ile
            180                 185                 190         
Thr Leu Lys Glu Ala Asn Glu Ile Leu Gln Arg Ser Lys Lys Gly Lys
        195                 200                 205             
Leu Pro Ile Val Asn Glu Asp Asp Glu Leu Val Ala Ile Ile Ala Arg
    210                 215                 220                 
Thr Asp Leu Lys Lys Asn Arg Asp Tyr Pro Leu Ala Ser Lys Asp Ala
225                 230                 235                 240 
Lys Lys Gln Leu Leu Cys Gly Ala Ala Ile Gly Thr His Glu Asp Asp
                245                 250                 255     
Lys Tyr Arg Leu Asp Leu Leu Ala Gln Ala Gly Val Asp Val Val Val
            260                 265                 270         
Leu Asp Ser Ser Gln Gly Asn Ser Ile Phe Gln Ile Asn Met Ile Lys
        275                 280                 285             
Tyr Ile Lys Asp Lys Tyr Pro Asn Leu Gln Val Ile Gly Gly Asn Val
    290                 295                 300                 
Val Thr Ala Ala Gln Ala Lys Asn Leu Ile Asp Ala Gly Val Asp Ala
305                 310                 315                 320 
Leu Arg Val Gly Met Gly Ser Gly Ser Ile Cys Ile Thr Gln Glu Val
                325                 330                 335     
Leu Ala Cys Gly Arg Pro Gln Ala Thr Ala Val Tyr Lys Val Ser Glu
            340                 345                 350         
Tyr Ala Arg Arg Phe Gly Val Pro Val Ile Ala Asp Gly Gly Ile Gln
        355                 360                 365             
Asn Val Gly His Ile Ala Lys Ala Leu Ala Leu Gly Ala Ser Thr Val
    370                 375                 380                 
Met Met Gly Ser Leu Leu Ala Ala Thr Thr Glu Ala Pro Gly Glu Tyr
385                 390                 395                 400 
Phe Phe Ser Asp Gly Ile Arg Leu Lys Lys Tyr Arg Gly Met Gly Ser
                405                 410                 415     
Leu Asp Ala Met Asp Lys His Leu Ser Ser Gln Asn Arg Tyr Phe Ser
            420                 425                 430         
Glu Ala Asp Lys Ile Lys Val Ala Gln Gly Val Ser Gly Ala Val Gln
        435                 440                 445             
Asp Lys Gly Ser Ile His Lys Phe Val Pro Tyr Leu Ile Ala Gly Ile
    450                 455                 460                 
Gln His Ser Cys Gln Asp Ile Gly Ala Lys Ser Leu Thr Gln Val Arg
465                 470                 475                 480 
Ala Met Met Tyr Ser Gly Glu Leu Lys Phe Glu Lys Arg Thr Ser Ser
                485                 490                 495     
Ala Gln Val Glu Gly Gly Val His Ser Leu His Ser Tyr Glu Lys Arg
            500                 505                 510         
Leu Phe
        


<210> 441
<211> 1257
<212> PRT
<213> Homo sapiens

<400> 441
Met Ala Ser Cys Ser Phe Thr Arg Asp Gln Ala Thr Arg Arg Leu Arg
 1               5                  10                  15      
Gly Ala Ala Ala Ala Ala Ala Ala Ala Leu Ala Ala Val Val Thr Thr
            20                  25                  30          
Pro Leu Leu Ser Ser Gly Thr Pro Thr Ala Leu Ile Gly Thr Gly Ser
        35                  40                  45              
Ser Cys Pro Gly Ala Met Trp Leu Ser Thr Ala Thr Gly Ser Arg Ser
    50                  55                  60                  
Asp Ser Glu Ser Glu Glu Glu Asp Leu Pro Val Gly Glu Glu Val Cys
65                  70                  75                  80  
Lys Arg Gly Tyr Leu Arg Lys Gln Lys His Gly His Arg Arg Tyr Phe
                85                  90                  95      
Val Leu Lys Leu Glu Thr Ala Asp Ala Pro Ala Arg Leu Glu Tyr Tyr
            100                 105                 110         
Glu Asn Ala Arg Lys Phe Arg His Ser Val Arg Ala Ala Ala Ala Ala
        115                 120                 125             
Ala Ala Ala Ala Ala Ser Gly Ala Ala Ile Pro Pro Leu Ile Pro Pro
    130                 135                 140                 
Arg Arg Val Ile Thr Leu Tyr Gln Cys Phe Ser Val Ser Gln Arg Ala
145                 150                 155                 160 
Asp Ala Arg Tyr Arg His Leu Ile Ala Leu Phe Thr Gln Asp Glu Tyr
                165                 170                 175     
Phe Ala Met Val Ala Glu Asn Glu Ser Glu Gln Glu Ser Trp Tyr Leu
            180                 185                 190         
Leu Leu Ser Arg Leu Ile Leu Glu Ser Lys Arg Arg Arg Cys Gly Thr
        195                 200                 205             
Leu Gly Ala Gln Pro Asp Gly Glu Pro Ala Ala Leu Ala Ala Ala Ala
    210                 215                 220                 
Ala Ala Glu Pro Pro Phe Tyr Lys Asp Val Trp Gln Val Ile Val Lys
225                 230                 235                 240 
Pro Arg Gly Leu Gly His Arg Lys Glu Leu Ser Gly Val Phe Arg Leu
                245                 250                 255     
Cys Leu Thr Asp Glu Glu Val Val Phe Val Arg Leu Asn Thr Glu Val
            260                 265                 270         
Ala Ser Val Val Val Gln Leu Leu Ser Ile Arg Arg Cys Gly His Ser
        275                 280                 285             
Glu Gln Tyr Phe Phe Leu Glu Val Gly Arg Ser Thr Val Ile Gly Pro
    290                 295                 300                 
Gly Glu Leu Trp Met Gln Val Asp Asp Cys Val Val Ala Gln Asn Met
305                 310                 315                 320 
His Glu Leu Phe Leu Glu Lys Met Arg Ala Leu Cys Ala Asp Glu Tyr
                325                 330                 335     
Arg Ala Arg Cys Arg Ser Tyr Ser Ile Ser Ile Gly Ala His Leu Leu
            340                 345                 350         
Thr Leu Leu Ser Ala Arg Arg His Leu Gly Leu Val Pro Leu Glu Pro
        355                 360                 365             
Gly Gly Trp Leu Arg Arg Ser Arg Phe Glu Gln Phe Cys His Leu Arg
    370                 375                 380                 
Ala Ile Gly Asp Gly Glu Asp Glu Met Leu Phe Thr Arg Arg Phe Val
385                 390                 395                 400 
Thr Pro Ser Glu Pro Val Ala His Ser Arg Arg Gly Arg Leu His Leu
                405                 410                 415     
Pro Arg Gly Arg Arg Ser Arg Arg Ala Val Ser Val Pro Ala Ser Phe
            420                 425                 430         
Phe Arg Arg Leu Ala Pro Ser Pro Ala Arg Pro Arg His Pro Ala Glu
        435                 440                 445             
Ala Pro Asn Asn Gly Ala Arg Leu Ser Ser Glu Val Ser Gly Ser Gly
    450                 455                 460                 
Ser Gly Asn Phe Gly Glu Glu Gly Asn Pro Gln Gly Lys Glu Asp Gln
465                 470                 475                 480 
Glu Gly Ser Gly Gly Asp Tyr Met Pro Met Asn Asn Trp Gly Ser Gly
                485                 490                 495     
Asn Gly Arg Gly Ser Gly Gly Gly Gln Gly Ser Asn Gly Gln Gly Ser
            500                 505                 510         
Ser Ser His Ser Ser Gly Gly Asn Gln Cys Ser Gly Glu Gly Gln Gly
        515                 520                 525             
Ser Arg Gly Gly Gln Gly Ser Asn Gly Gln Gly Ser Gly Gly Asn Gln
    530                 535                 540                 
Cys Ser Arg Asp Gly Gln Gly Thr Ala Gly Gly His Gly Ser Gly Gly
545                 550                 555                 560 
Gly Gln Arg Pro Gly Gly Gly His Gly Ser Gly Gly Gly Gln Gly Pro
                565                 570                 575     
Gly Asp Gly His Gly Ser Gly Gly Gly Lys Asn Ser Gly Gly Gly Lys
            580                 585                 590         
Gly Ser Gly Ser Gly Lys Gly Ser Asp Gly Asp Gly Glu Arg Gly Lys
        595                 600                 605             
Ser Leu Lys Lys Arg Ser Tyr Phe Gly Lys Leu Thr Gln Ser Lys Gln
    610                 615                 620                 
Gln Gln Met Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala
625                 630                 635                 640 
Gly Gly Thr Gly Gly Lys Gly Lys Ser Gly Gly Arg Phe Arg Leu Tyr
                645                 650                 655     
Phe Cys Val Asp Arg Gly Ala Thr Lys Glu Cys Lys Glu Ala Lys Glu
            660                 665                 670         
Val Lys Asp Ala Glu Ile Pro Glu Gly Ala Ala Arg Gly Pro His Arg
        675                 680                 685             
Ala Arg Ala Phe Asp Glu Asp Glu Asp Asp Pro Tyr Val Pro Met Arg
    690                 695                 700                 
Pro Gly Val Ala Thr Pro Leu Val Ser Ser Ser Asp Tyr Met Pro Met
705                 710                 715                 720 
Ala Pro Gln Asn Val Ser Ala Ser Lys Lys Arg His Ser Arg Ser Pro
                725                 730                 735     
Phe Glu Asp Ser Arg Gly Tyr Met Met Met Phe Pro Arg Val Ser Pro
            740                 745                 750         
Pro Pro Ala Pro Ser Pro Pro Lys Ala Pro Asp Thr Asn Lys Glu Asp
        755                 760                 765             
Asp Ser Lys Asp Asn Asp Ser Glu Ser Asp Tyr Met Phe Met Ala Pro
    770                 775                 780                 
Gly Ala Gly Ala Ile Pro Lys Asn Pro Arg Asn Pro Gln Gly Gly Ser
785                 790                 795                 800 
Ser Ser Lys Ser Trp Ser Ser Tyr Phe Ser Leu Pro Asn Pro Phe Arg
                805                 810                 815     
Ser Ser Pro Leu Gly Gln Asn Asp Asn Ser Glu Tyr Val Pro Met Leu
            820                 825                 830         
Pro Gly Lys Phe Leu Gly Arg Gly Leu Asp Lys Glu Val Ser Tyr Asn
        835                 840                 845             
Trp Asp Pro Lys Asp Ala Ala Ser Lys Pro Ser Gly Glu Gly Ser Phe
    850                 855                 860                 
Ser Lys Pro Gly Asp Gly Gly Ser Pro Ser Lys Pro Ser Asp His Glu
865                 870                 875                 880 
Pro Pro Lys Asn Lys Ala Lys Arg Pro Asn Arg Leu Ser Phe Ile Thr
                885                 890                 895     
Lys Gly Tyr Lys Ile Lys Pro Lys Pro Gln Lys Pro Thr His Glu Gln
            900                 905                 910         
Arg Glu Ala Asp Ser Ser Ser Asp Tyr Val Asn Met Asp Phe Thr Lys
        915                 920                 925             
Arg Glu Ser Asn Thr Pro Ala Pro Ser Thr Gln Gly Leu Pro Asp Ser
    930                 935                 940                 
Trp Gly Ile Ile Ala Glu Pro Arg Gln Ser Ala Phe Ser Asn Tyr Val
945                 950                 955                 960 
Asn Val Glu Phe Gly Val Pro Phe Pro Asn Pro Ala Asn Asp Leu Ser
                965                 970                 975     
Asp Leu Leu Arg Ala Ile Pro Arg Ala Asn Pro Leu Ser Leu Asp Ser
            980                 985                 990         
Ala Arg Trp Pro Leu Pro Pro Leu Pro Leu Ser Ala Thr Gly Ser Asn
        995                 1000                1005            
Ala Ile Glu Glu Glu Gly Asp Tyr Ile Glu Val Ile Phe Asn Ser Ala
    1010                1015                1020                
Met Thr Pro Ala Met Ala Leu Ala Asp Ser Ala Ile Arg Tyr Asp Ala
1025                1030                1035                1040
Glu Thr Gly Arg Ile Tyr Val Val Asp Pro Phe Ser Glu Cys Cys Met
                1045                1050                1055    
Asp Ile Ser Leu Ser Pro Ser Arg Cys Ser Glu Pro Pro Pro Val Ala
            1060                1065                1070        
Arg Leu Leu Gln Glu Glu Glu Gln Glu Arg Arg Arg Pro Gln Ser Arg
        1075                1080                1085            
Ser Gln Ser Phe Phe Ala Ala Ala Arg Ala Ala Val Ser Ala Phe Pro
    1090                1095                1100                
Thr Asp Ser Leu Glu Arg Asp Leu Ser Pro Ser Ser Ala Pro Ala Val
1105                1110                1115                1120
Ala Ser Ala Ala Glu Pro Thr Leu Ala Leu Ser Gln Val Val Ala Ala
                1125                1130                1135    
Ala Ser Ala Leu Ala Ala Ala Pro Gly Ile Gly Ala Ala Ala Ala Ala
            1140                1145                1150        
Ala Gly Phe Asp Ser Ala Ser Ala Arg Trp Phe Gln Pro Val Ala Asn
        1155                1160                1165            
Ala Ala Asp Ala Glu Ala Val Arg Gly Ala Gln Asp Val Ala Gly Gly
    1170                1175                1180                
Ser Asn Pro Gly Ala His Asn Pro Ser Ala Asn Leu Ala Arg Gly Asp
1185                1190                1195                1200
Asn Gln Ala Gly Gly Ala Ala Ala Ala Ala Ala Ala Pro Glu Pro Pro
                1205                1210                1215    
Pro Arg Ser Arg Arg Val Pro Arg Pro Pro Glu Arg Glu Asp Ser Asp
            1220                1225                1230        
Asn Asp Asp Asp Thr His Val Arg Met Asp Phe Ala Arg Arg Asp Asn
        1235                1240                1245            
Gln Phe Asp Ser Pro Lys Arg Gly Arg
    1250                1255        


<210> 442
<211> 2671
<212> PRT
<213> Homo sapiens

<400> 442
Met Ser Glu Met Ser Ser Phe Leu His Ile Gly Asp Ile Val Ser Leu
 1               5                  10                  15      
Tyr Ala Glu Gly Ser Val Asn Gly Phe Ile Ser Thr Leu Gly Leu Val
            20                  25                  30          
Asp Asp Arg Cys Val Val Glu Pro Ala Ala Gly Asp Leu Asp Asn Pro
        35                  40                  45              
Pro Lys Lys Phe Arg Asp Cys Leu Phe Lys Val Cys Pro Met Asn Arg
    50                  55                  60                  
Tyr Ser Ala Gln Lys Gln Tyr Trp Lys Ala Lys Gln Thr Lys Gln Asp
65                  70                  75                  80  
Lys Glu Lys Ile Ala Asp Val Val Leu Leu Gln Lys Leu Gln His Ala
                85                  90                  95      
Ala Gln Met Glu Gln Lys Gln Asn Asp Thr Glu Asn Lys Lys Val His
            100                 105                 110         
Gly Asp Val Val Lys Tyr Gly Ser Val Ile Gln Leu Leu His Met Lys
        115                 120                 125             
Ser Asn Lys Tyr Leu Thr Val Asn Lys Arg Leu Pro Ala Leu Leu Glu
    130                 135                 140                 
Lys Asn Ala Met Arg Val Thr Leu Asp Ala Thr Gly Asn Glu Gly Ser
145                 150                 155                 160 
Trp Leu Phe Ile Gln Pro Phe Trp Lys Leu Arg Ser Asn Gly Asp Asn
                165                 170                 175     
Val Val Val Gly Asp Lys Val Ile Leu Asn Pro Val Asn Ala Gly Gln
            180                 185                 190         
Pro Leu His Ala Ser Asn Tyr Glu Leu Ser Asp Asn Ala Gly Cys Lys
        195                 200                 205             
Glu Val Asn Ser Val Asn Cys Asn Thr Ser Trp Lys Ile Asn Leu Phe
    210                 215                 220                 
Met Gln Phe Arg Asp His Leu Glu Glu Val Leu Lys Gly Gly Asp Val
225                 230                 235                 240 
Val Arg Leu Phe His Ala Glu Gln Glu Lys Phe Leu Thr Cys Asp Glu
                245                 250                 255     
Tyr Lys Gly Lys Leu Gln Val Phe Leu Arg Thr Thr Leu Arg Gln Ser
            260                 265                 270         
Ala Thr Ser Ala Thr Ser Ser Asn Ala Leu Trp Glu Val Glu Val Val
        275                 280                 285             
His His Asp Pro Cys Arg Gly Gly Ala Gly His Trp Asn Gly Leu Tyr
    290                 295                 300                 
Arg Phe Lys His Leu Ala Thr Gly Asn Tyr Leu Ala Ala Glu Glu Asn
305                 310                 315                 320 
Pro Ser Tyr Lys Gly Asp Ala Ser Asp Pro Lys Ala Ala Gly Met Gly
                325                 330                 335     
Ala Gln Gly Arg Thr Gly Arg Arg Asn Ala Gly Glu Lys Ile Lys Tyr
            340                 345                 350         
Cys Leu Val Ala Val Pro His Gly Asn Asp Ile Ala Ser Leu Phe Glu
        355                 360                 365             
Leu Asp Pro Thr Thr Leu Gln Lys Thr Asp Ser Phe Val Pro Arg Asn
    370                 375                 380                 
Ser Tyr Val Arg Leu Arg His Leu Cys Thr Asn Thr Trp Ile Gln Ser
385                 390                 395                 400 
Thr Asn Val Pro Ile Asp Ile Glu Glu Glu Arg Pro Ile Arg Leu Met
                405                 410                 415     
Leu Gly Thr Cys Pro Thr Lys Glu Asp Lys Glu Ala Phe Ala Ile Val
            420                 425                 430         
Ser Val Pro Val Ser Glu Ile Arg Asp Leu Asp Phe Ala Asn Asp Ala
        435                 440                 445             
Ser Ser Met Leu Ala Ser Ala Val Glu Lys Leu Asn Glu Gly Phe Ile
    450                 455                 460                 
Ser Gln Asn Asp Arg Arg Phe Val Ile Gln Leu Leu Glu Asp Leu Val
465                 470                 475                 480 
Phe Phe Val Ser Asp Val Pro Asn Asn Gly Gln Asn Val Leu Asp Ile
                485                 490                 495     
Met Val Thr Lys Pro Asn Arg Glu Arg Gln Lys Leu Met Arg Glu Gln
            500                 505                 510         
Asn Ile Leu Lys Gln Val Phe Gly Ile Leu Lys Val Pro Phe Arg Glu
        515                 520                 525             
Lys Gly Gly Glu Gly Pro Leu Val Arg Leu Glu Glu Leu Ser Asp Gln
    530                 535                 540                 
Lys Asn Ala Pro Tyr Gln His Met Phe Arg Leu Cys Tyr Arg Val Leu
545                 550                 555                 560 
Arg Tyr Ser Gln Glu Asp Tyr Arg Lys Asn Gln Glu His Ile Ala Lys
                565                 570                 575     
Gln Phe Gly Met Met Gln Ser Gln Ile Gly Tyr Asp Ile Leu Ala Glu
            580                 585                 590         
Asp Thr Ile Thr Ala Leu Leu His Asn Asn Arg Lys Leu Leu Glu Lys
        595                 600                 605             
His Ile Thr Lys Thr Glu Val Glu Thr Phe Val Ser Leu Val Arg Lys
    610                 615                 620                 
Asn Arg Glu Pro Arg Phe Leu Asp Tyr Leu Ser Asp Leu Cys Val Ser
625                 630                 635                 640 
Asn His Ile Ala Ile Pro Val Thr Gln Glu Leu Ile Cys Lys Cys Val
                645                 650                 655     
Leu Asp Pro Lys Asn Ser Asp Ile Leu Ile Arg Thr Glu Leu Arg Pro
            660                 665                 670         
Val Lys Glu Met Ala Gln Ser His Glu Tyr Leu Ser Ile Glu Tyr Ser
        675                 680                 685             
Glu Glu Glu Val Trp Leu Thr Trp Thr Asp Lys Asn Asn Glu His His
    690                 695                 700                 
Glu Lys Ser Val Arg Gln Leu Ala Gln Glu Ala Arg Ala Gly Asn Ala
705                 710                 715                 720 
His Asp Glu Asn Val Leu Ser Tyr Tyr Arg Tyr Gln Leu Lys Leu Phe
                725                 730                 735     
Ala Arg Met Cys Leu Asp Arg Gln Tyr Leu Ala Ile Asp Glu Ile Ser
            740                 745                 750         
Gln Gln Leu Gly Val Asp Leu Ile Phe Leu Cys Met Ala Asp Glu Met
        755                 760                 765             
Leu Pro Phe Asp Leu Arg Ala Ser Phe Cys His Leu Met Leu His Val
    770                 775                 780                 
His Val Asp Arg Asp Pro Gln Glu Leu Val Thr Pro Val Lys Phe Ala
785                 790                 795                 800 
Arg Leu Trp Thr Glu Ile Pro Thr Ala Ile Thr Ile Lys Asp Tyr Asp
                805                 810                 815     
Ser Asn Leu Asn Ala Ser Arg Asp Asp Lys Lys Asn Lys Phe Ala Asn
            820                 825                 830         
Thr Met Glu Phe Val Glu Asp Tyr Leu Asn Asn Val Val Ser Glu Ala
        835                 840                 845             
Val Pro Phe Ala Asn Glu Glu Lys Asn Lys Leu Thr Phe Glu Val Val
    850                 855                 860                 
Ser Leu Ala His Asn Leu Ile Tyr Phe Gly Phe Tyr Ser Phe Ser Glu
865                 870                 875                 880 
Leu Leu Arg Leu Thr Arg Thr Leu Leu Gly Ile Ile Asp Cys Val Gln
                885                 890                 895     
Gly Pro Pro Ala Met Leu Gln Ala Tyr Glu Asp Pro Gly Gly Lys Asn
            900                 905                 910         
Val Arg Arg Ser Ile Gln Gly Val Gly His Met Met Ser Thr Met Val
        915                 920                 925             
Leu Ser Arg Lys Gln Ser Val Phe Ser Ala Pro Ser Leu Ser Ala Gly
    930                 935                 940                 
Ala Ser Ala Ala Glu Pro Leu Asp Arg Ser Lys Phe Glu Glu Asn Glu
945                 950                 955                 960 
Asp Ile Val Val Met Glu Thr Lys Leu Lys Ile Leu Glu Ile Leu Gln
                965                 970                 975     
Phe Ile Leu Asn Val Arg Leu Asp Tyr Arg Ile Ser Tyr Leu Leu Ser
            980                 985                 990         
Val Phe Lys Lys Glu Phe Val Glu Val Phe Pro Met Gln Asp Ser Gly
        995                 1000                1005            
Ala Asp Gly Thr Ala Pro Ala Phe Asp Ser Thr Thr Ala Asn Met Asn
    1010                1015                1020                
Leu Asp Arg Ile Gly Glu Gln Ala Glu Ala Met Phe Gly Val Gly Lys
1025                1030                1035                1040
Thr Ser Ser Met Leu Glu Val Asp Asp Glu Gly Gly Arg Met Phe Leu
                1045                1050                1055    
Arg Val Leu Ile His Leu Thr Met His Asp Tyr Ala Pro Leu Val Ser
            1060                1065                1070        
Gly Ala Leu Gln Leu Leu Phe Lys His Phe Ser Gln Arg Gln Glu Ala
        1075                1080                1085            
Met His Thr Phe Lys Gln Val Gln Leu Leu Ile Ser Ala Gln Asp Val
    1090                1095                1100                
Glu Asn Tyr Lys Val Ile Lys Ser Glu Leu Asp Arg Leu Arg Thr Met
1105                1110                1115                1120
Val Glu Lys Ser Glu Leu Trp Val Asp Lys Lys Gly Ser Gly Lys Gly
                1125                1130                1135    
Glu Glu Val Glu Ala Gly Thr Ala Lys Asp Lys Lys Glu Arg Pro Thr
            1140                1145                1150        
Asp Glu Glu Gly Phe Leu His Pro Pro Gly Glu Lys Ser Ser Glu Asn
        1155                1160                1165            
Tyr Gln Ile Val Lys Gly Ile Leu Glu Arg Leu Asn Lys Met Cys Gly
    1170                1175                1180                
Val Gly Glu Gln Met Arg Lys Lys Gln Gln Arg Leu Leu Lys Asn Met
1185                1190                1195                1200
Asp Ala His Lys Val Met Leu Asp Leu Leu Gln Ile Pro Tyr Asp Lys
                1205                1210                1215    
Gly Asp Ala Lys Met Met Glu Ile Leu Arg Tyr Thr His Gln Phe Leu
            1220                1225                1230        
Gln Lys Phe Cys Ala Gly Asn Pro Gly Asn Gln Ala Leu Leu His Lys
        1235                1240                1245            
His Leu His Leu Phe Leu Thr Pro Gly Leu Leu Glu Ala Glu Thr Met
    1250                1255                1260                
Gln His Ile Phe Leu Asn Asn Tyr Gln Leu Cys Ser Glu Ile Ser Glu
1265                1270                1275                1280
Pro Val Leu Gln His Phe Val His Leu Leu Ala Thr His Gly Arg His
                1285                1290                1295    
Val Gln Tyr Leu Asp Phe Leu His Thr Val Ile Lys Ala Glu Gly Lys
            1300                1305                1310        
Tyr Val Lys Lys Cys Gln Asp Met Ile Met Thr Glu Leu Thr Asn Ala
        1315                1320                1325            
Gly Asp Asp Val Val Val Phe Tyr Asn Asp Lys Ala Ser Leu Ala His
    1330                1335                1340                
Leu Leu Asp Met Met Lys Ala Ala Arg Asp Gly Val Glu Asp His Ser
1345                1350                1355                1360
Pro Leu Met Tyr His Ile Ser Leu Val Asp Leu Leu Ala Ala Cys Ala
                1365                1370                1375    
Glu Gly Lys Asn Val Tyr Thr Glu Ile Lys Cys Thr Ser Leu Val Pro
            1380                1385                1390        
Leu Glu Asp Val Val Ser Val Val Thr His Glu Asp Cys Ile Thr Glu
        1395                1400                1405            
Val Lys Met Ala Tyr Val Asn Phe Val Asn His Cys Tyr Val Asp Thr
    1410                1415                1420                
Glu Val Glu Met Lys Glu Ile Tyr Thr Ser Asn His Ile Trp Thr Leu
1425                1430                1435                1440
Phe Glu Asn Phe Thr Leu Asp Met Ala Arg Val Cys Ser Lys Arg Glu
                1445                1450                1455    
Lys Arg Val Ala Asp Pro Thr Leu Glu Lys Tyr Val Leu Ser Val Val
            1460                1465                1470        
Leu Asp Thr Ile Asn Ala Phe Phe Ser Ser Pro Phe Ser Glu Asn Ser
        1475                1480                1485            
Thr Ser Leu Gln Thr His Gln Pro Val Val Val Gln Leu Leu Gln Ser
    1490                1495                1500                
Thr Thr Arg Leu Leu Glu Cys Pro Trp Leu Gln Gln Gln His Lys Gly
1505                1510                1515                1520
Ser Val Glu Ala Cys Ile Arg Thr Leu Ala Met Val Ala Lys Gly Arg
                1525                1530                1535    
Ala Ile Leu Leu Pro Met Asp Leu Asp Ala His Ile Ser Ser Met Leu
            1540                1545                1550        
Ser Ser Gly Ala Ser Cys Ala Ala Ala Ala Gln Arg Asn Ala Ser Ser
        1555                1560                1565            
Tyr Lys Ala Thr Thr Arg Ala Phe Pro Arg Val Thr Pro Thr Ala Asn
    1570                1575                1580                
Gln Trp Asp Tyr Lys Asn Ile Ile Glu Lys Leu Gln Asp Ile Ile Thr
1585                1590                1595                1600
Ala Leu Glu Glu Arg Leu Lys Pro Leu Val Gln Ala Glu Leu Ser Val
                1605                1610                1615    
Leu Val Asp Val Leu His Trp Pro Glu Leu Leu Phe Leu Glu Gly Ser
            1620                1625                1630        
Glu Ala Tyr Gln Arg Cys Glu Ser Gly Gly Phe Leu Ser Lys Leu Ile
        1635                1640                1645            
Gln His Thr Lys Asp Leu Met Glu Ser Glu Glu Lys Leu Cys Ile Lys
    1650                1655                1660                
Val Leu Arg Thr Leu Gln Gln Met Leu Val Lys Lys Thr Lys Tyr Gly
1665                1670                1675                1680
Asp Arg Gly Asn Gln Leu Arg Lys Met Leu Leu Gln Asn Tyr Leu Gln
                1685                1690                1695    
Asn Arg Lys Ser Thr Ser Arg Gly Asp Leu Pro Asp Pro Ile Gly Thr
            1700                1705                1710        
Gly Leu Asp Pro Asp Trp Ser Ala Ile Ala Ala Thr Gln Cys Arg Leu
        1715                1720                1725            
Asp Lys Glu Gly Ala Thr Lys Leu Val Cys Asp Leu Ile Thr Ser Thr
    1730                1735                1740                
Lys Asn Glu Lys Ile Phe Gln Glu Ser Ile Gly Leu Ala Ile His Leu
1745                1750                1755                1760
Leu Asp Gly Gly Asn Thr Glu Ile Gln Lys Ser Phe His Asn Leu Met
                1765                1770                1775    
Met Ser Asp Lys Lys Ser Glu Arg Phe Phe Lys Val Leu His Asp Arg
            1780                1785                1790        
Met Lys Arg Ala Gln Gln Glu Thr Lys Ser Thr Val Ala Val Asn Met
        1795                1800                1805            
Asn Asp Leu Gly Ser Gln Pro His Glu Asp Arg Glu Pro Val Asp Pro
    1810                1815                1820                
Thr Thr Lys Gly Arg Val Ala Ser Phe Ser Ile Pro Gly Ser Ser Ser
1825                1830                1835                1840
Arg Tyr Ser Leu Gly Pro Ser Leu Arg Arg Gly His Glu Val Ser Glu
                1845                1850                1855    
Arg Val Gln Ser Ser Glu Met Gly Thr Ser Val Leu Ile Met Gln Pro
            1860                1865                1870        
Ile Leu Arg Phe Leu Gln Leu Leu Cys Glu Asn His Asn Arg Asp Leu
        1875                1880                1885            
Gln Asn Phe Leu Arg Cys Gln Asn Asn Lys Thr Asn Tyr Asn Leu Val
    1890                1895                1900                
Cys Glu Thr Leu Gln Phe Leu Asp Ile Met Cys Gly Ser Thr Thr Gly
1905                1910                1915                1920
Gly Leu Gly Leu Leu Gly Leu Tyr Ile Asn Glu Asp Asn Val Gly Leu
                1925                1930                1935    
Val Ile Gln Thr Leu Glu Thr Leu Thr Glu Tyr Cys Gln Gly Pro Cys
            1940                1945                1950        
His Glu Asn Gln Thr Cys Ile Val Thr His Glu Ser Asn Gly Ile Asp
        1955                1960                1965            
Ile Ile Thr Ala Leu Ile Leu Asn Asp Ile Ser Pro Leu Cys Lys Tyr
    1970                1975                1980                
Arg Met Asp Leu Val Leu Gln Leu Lys Asp Asn Ala Ser Lys Leu Leu
1985                1990                1995                2000
Leu Ala Leu Met Glu Ser Arg His Asp Ser Glu Asn Ala Glu Arg Ile
                2005                2010                2015    
Leu Ile Ser Leu Arg Pro Gln Glu Leu Val Asp Val Ile Lys Lys Ala
            2020                2025                2030        
Tyr Leu Gln Glu Glu Glu Arg Glu Asn Ser Glu Val Ser Pro Arg Glu
        2035                2040                2045            
Val Gly His Asn Ile Tyr Ile Leu Ala Leu Gln Leu Ser Arg His Asn
    2050                2055                2060                
Lys Gln Leu Gln His Leu Leu Lys Pro Val Lys Arg Ile Gln Glu Glu
2065                2070                2075                2080
Glu Ala Glu Gly Ile Ser Ser Met Leu Ser Leu Asn Asn Lys Gln Leu
                2085                2090                2095    
Ser Gln Met Leu Lys Ser Ser Ala Pro Ala Gln Glu Glu Glu Glu Asp
            2100                2105                2110        
Pro Leu Ala Tyr Tyr Glu Asn His Thr Ser Gln Ile Glu Ile Val Arg
        2115                2120                2125            
Gln Asp Arg Ser Met Glu Gln Ile Val Phe Pro Val Pro Gly Ile Cys
    2130                2135                2140                
Gln Phe Leu Thr Glu Glu Thr Lys His Arg Leu Phe Thr Thr Thr Glu
2145                2150                2155                2160
Gln Asp Glu Gln Gly Ser Lys Val Ser Asp Phe Phe Asp Gln Ser Ser
                2165                2170                2175    
Phe Leu His Asn Glu Met Glu Trp Gln Arg Asn Val Arg Ser Met Pro
            2180                2185                2190        
Leu Ile Tyr Trp Phe Ser Arg Arg Met Thr Leu Trp Gly Ser Ile Ser
        2195                2200                2205            
Phe Asn Leu Ala Val Phe Ile Asn Ile Ile Ile Ala Phe Phe Tyr Pro
    2210                2215                2220                
Tyr Met Glu Gly Ala Ser Thr Gly Val Leu Asp Ser Pro Leu Ile Ser
2225                2230                2235                2240
Leu Leu Phe Trp Ile Leu Ile Cys Phe Ser Ile Ala Ala Leu Phe Thr
                2245                2250                2255    
Lys Arg Tyr Ser Ile Arg Pro Leu Ile Val Ala Leu Ile Leu Arg Ser
            2260                2265                2270        
Ile Tyr Tyr Leu Gly Ile Gly Pro Thr Leu Asn Ile Leu Gly Ala Leu
        2275                2280                2285            
Asn Leu Thr Asn Lys Ile Val Phe Val Val Ser Phe Val Gly Asn Arg
    2290                2295                2300                
Gly Thr Phe Ile Arg Gly Tyr Lys Ala Met Val Met Asp Met Glu Phe
2305                2310                2315                2320
Leu Tyr His Val Gly Tyr Ile Leu Thr Ser Val Leu Gly Leu Phe Ala
                2325                2330                2335    
His Glu Leu Phe Tyr Ser Ile Leu Leu Phe Asp Leu Ile Tyr Arg Glu
            2340                2345                2350        
Glu Thr Leu Phe Asn Val Ile Lys Ser Val Thr Arg Asn Gly Arg Ser
        2355                2360                2365            
Ile Leu Leu Thr Ala Leu Leu Ala Leu Ile Leu Val Tyr Leu Phe Ser
    2370                2375                2380                
Ile Val Gly Phe Leu Phe Leu Lys Asp Asp Phe Ile Leu Glu Val Asp
2385                2390                2395                2400
Arg Leu Pro Asn Asn His Ser Thr Ala Ser Pro Leu Gly Met Pro His
                2405                2410                2415    
Gly Ala Ala Ala Phe Val Asp Thr Cys Ser Gly Asp Lys Met Asp Cys
            2420                2425                2430        
Val Ser Gly Leu Ser Val Pro Glu Val Leu Glu Glu Asp Arg Glu Leu
        2435                2440                2445            
Asp Ser Thr Glu Arg Ala Cys Asp Thr Leu Leu Met Cys Ile Val Thr
    2450                2455                2460                
Val Met Asn His Gly Leu Arg Asn Gly Gly Gly Val Gly Asp Ile Leu
2465                2470                2475                2480
Arg Lys Pro Ser Lys Asp Glu Ser Leu Phe Pro Ala Arg Val Val Tyr
                2485                2490                2495    
Asp Leu Leu Phe Phe Phe Ile Val Ile Ile Ile Val Leu Asn Leu Ile
            2500                2505                2510        
Phe Gly Val Ile Ile Asp Thr Phe Ala Asp Leu Arg Ser Glu Lys Gln
        2515                2520                2525            
Lys Lys Glu Glu Ile Leu Lys Thr Thr Cys Phe Ile Cys Gly Leu Glu
    2530                2535                2540                
Arg Asp Lys Phe Asp Asn Lys Thr Val Ser Phe Glu Glu His Ile Lys
2545                2550                2555                2560
Leu Glu His Asn Met Trp Asn Tyr Leu Tyr Phe Ile Val Leu Val Arg
                2565                2570                2575    
Val Lys Asn Lys Thr Asp Tyr Thr Gly Pro Glu Ser Tyr Val Ala Gln
            2580                2585                2590        
Met Ile Lys Asn Lys Asn Leu Asp Trp Phe Pro Arg Met Arg Ala Met
        2595                2600                2605            
Ser Leu Val Ser Asn Glu Gly Glu Gly Glu Gln Asn Glu Ile Arg Ile
    2610                2615                2620                
Leu Gln Asp Lys Leu Asn Ser Thr Met Lys Leu Val Ser His Leu Thr
2625                2630                2635                2640
Ala Gln Leu Asn Glu Leu Lys Glu Gln Met Thr Glu Gln Arg Lys Arg
                2645                2650                2655    
Arg Gln Arg Leu Gly Phe Val Asp Val Gln Asn Cys Ile Ser Arg
            2660                2665                2670    


<210> 443
<211> 485
<212> PRT
<213> Homo sapiens

<400> 443
Met Gly Glu Pro Gly Phe Phe Val Thr Gly Asp Arg Ala Gly Gly Arg
 1               5                  10                  15      
Ser Trp Cys Leu Arg Arg Val Gly Met Ser Ala Gly Trp Leu Leu Leu
            20                  25                  30          
Glu Asp Gly Cys Glu Val Thr Val Gly Arg Gly Phe Gly Val Thr Tyr
        35                  40                  45              
Gln Leu Val Ser Lys Ile Cys Pro Leu Met Ile Ser Arg Asn His Cys
    50                  55                  60                  
Val Leu Lys Gln Asn Pro Glu Gly Gln Trp Thr Ile Met Asp Asn Lys
65                  70                  75                  80  
Ser Leu Asn Gly Val Trp Leu Asn Arg Ala Arg Leu Glu Pro Leu Arg
                85                  90                  95      
Val Tyr Ser Ile His Gln Gly Asp Tyr Ile Gln Leu Gly Val Pro Leu
            100                 105                 110         
Glu Asn Lys Glu Asn Ala Glu Tyr Glu Tyr Glu Val Thr Glu Glu Asp
        115                 120                 125             
Trp Glu Thr Ile Tyr Pro Cys Leu Ser Pro Lys Asn Asp Gln Met Ile
    130                 135                 140                 
Glu Lys Asn Lys Glu Leu Arg Thr Lys Arg Lys Phe Ser Leu Asp Glu
145                 150                 155                 160 
Leu Ala Gly Pro Gly Ala Glu Gly Pro Ser Asn Leu Lys Ser Lys Ile
                165                 170                 175     
Asn Lys Val Ser Cys Glu Ser Gly Gln Pro Val Lys Ser Gln Gly Lys
            180                 185                 190         
Gly Glu Val Ala Ser Thr Pro Ser Asp Asn Leu Asp Pro Lys Leu Thr
        195                 200                 205             
Ala Leu Glu Pro Ser Lys Thr Thr Gly Ala Pro Ile Tyr Pro Gly Phe
    210                 215                 220                 
Pro Lys Val Thr Glu Val His His Glu Gln Lys Ala Ser Asn Ser Ser
225                 230                 235                 240 
Ala Ser Gln Arg Ser Leu Gln Met Phe Lys Val Thr Met Ser Arg Ile
                245                 250                 255     
Leu Arg Leu Lys Ile Gln Met Gln Glu Lys His Glu Ala Val Met Asn
            260                 265                 270         
Val Lys Lys Gln Thr Gln Lys Gly Asn Ser Lys Lys Val Val Gln Met
        275                 280                 285             
Glu Gln Glu Leu Gln Asp Leu Gln Ser Gln Leu Cys Ala Glu Gln Ala
    290                 295                 300                 
Gln Gln Gln Ala Arg Val Glu Gln Leu Glu Lys Thr Phe Gln Glu Glu
305                 310                 315                 320 
Glu Gln His Leu Gln Gly Leu Glu Ile Ala Gln Gly Glu Lys Asp Leu
                325                 330                 335     
Lys Gln Gln Leu Ala Gln Ala Leu Gln Glu His Trp Ala Leu Met Glu
            340                 345                 350         
Glu Leu Asn Arg Ser Lys Lys Asp Phe Glu Ala Ile Ile Gln Ala Lys
        355                 360                 365             
Asn Lys Glu Leu Glu Gln Thr Lys Glu Glu Lys Glu Lys Met Gln Ala
    370                 375                 380                 
Gln Lys Glu Glu Val Leu Ser His Met Asn Asp Val Leu Glu Asn Glu
385                 390                 395                 400 
Leu Gln Cys Ile Ile Cys Ser Glu Tyr Phe Ile Glu Ala Val Thr Leu
                405                 410                 415     
Asn Cys Ala His Ser Phe Cys Ser Tyr Cys Ile Asn Glu Trp Met Lys
            420                 425                 430         
Arg Lys Ile Glu Cys Pro Ile Cys Arg Lys Asp Ile Lys Ser Lys Thr
        435                 440                 445             
Tyr Ser Leu Val Leu Asp Asn Cys Ile Asn Lys Met Val Asn Asn Leu
    450                 455                 460                 
Ser Ser Glu Val Lys Glu Arg Arg Ile Val Leu Ile Arg Glu Arg Lys
465                 470                 475                 480 
Ala Lys Arg Leu Phe
                485 


<210> 444
<211> 860
<212> PRT
<213> Homo sapiens

<400> 444
Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu
 1               5                  10                  15      
Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe
            20                  25                  30          
Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly
        35                  40                  45              
Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu
    50                  55                  60                  
Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn
65                  70                  75                  80  
Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp
                85                  90                  95      
Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp
            100                 105                 110         
Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys
        115                 120                 125             
Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro
    130                 135                 140                 
Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys
145                 150                 155                 160 
Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly
                165                 170                 175     
Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly
            180                 185                 190         
Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu
        195                 200                 205             
Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp
    210                 215                 220                 
Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu
225                 230                 235                 240 
Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp
                245                 250                 255     
Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn
            260                 265                 270         
Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu
        275                 280                 285             
Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp
    290                 295                 300                 
Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp
305                 310                 315                 320 
Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr
                325                 330                 335     
Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys
            340                 345                 350         
Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys
        355                 360                 365             
Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln
    370                 375                 380                 
Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr
385                 390                 395                 400 
Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg
                405                 410                 415     
Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu
            420                 425                 430         
Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln
        435                 440                 445             
Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser
    450                 455                 460                 
Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala
465                 470                 475                 480 
Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly
                485                 490                 495     
Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe
            500                 505                 510         
Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His
        515                 520                 525             
Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys
    530                 535                 540                 
Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile
545                 550                 555                 560 
Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr
                565                 570                 575     
Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly
            580                 585                 590         
Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro
        595                 600                 605             
Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile
    610                 615                 620                 
Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn
625                 630                 635                 640 
Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His
                645                 650                 655     
Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu
            660                 665                 670         
Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn
        675                 680                 685             
Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu
    690                 695                 700                 
Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala
705                 710                 715                 720 
Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val
                725                 730                 735     
Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu
            740                 745                 750         
Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser
        755                 760                 765             
His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro
    770                 775                 780                 
Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val
785                 790                 795                 800 
Phe Leu Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys
                805                 810                 815     
Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr
            820                 825                 830         
Glu Asp Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro
        835                 840                 845             
Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val Ala
    850                 855                 860 


<210> 445
<211> 202
<212> PRT
<213> Homo sapiens

<400> 445
Met Lys Val Leu Ala Ala Gly Val Val Pro Leu Leu Leu Val Leu His
 1               5                  10                  15      
Trp Lys His Gly Ala Gly Ser Pro Leu Pro Ile Thr Pro Val Asn Ala
            20                  25                  30          
Thr Cys Ala Ile Arg His Pro Cys His Asn Asn Leu Met Asn Gln Ile
        35                  40                  45              
Arg Ser Gln Leu Ala Gln Leu Asn Gly Ser Ala Asn Ala Leu Phe Ile
    50                  55                  60                  
Leu Tyr Tyr Thr Ala Gln Gly Glu Pro Phe Pro Asn Asn Leu Asp Lys
65                  70                  75                  80  
Leu Cys Gly Pro Asn Val Thr Asp Phe Pro Pro Phe His Ala Asn Gly
                85                  90                  95      
Thr Glu Lys Ala Lys Leu Val Glu Leu Tyr Arg Ile Val Val Tyr Leu
            100                 105                 110         
Gly Thr Ser Leu Gly Asn Ile Thr Arg Asp Gln Lys Ile Leu Asn Pro
        115                 120                 125             
Ser Ala Leu Ser Leu His Ser Lys Leu Asn Ala Thr Ala Asp Ile Leu
    130                 135                 140                 
Arg Gly Leu Leu Ser Asn Val Leu Cys Arg Leu Cys Ser Lys Tyr His
145                 150                 155                 160 
Val Gly His Val Asp Val Thr Tyr Gly Pro Asp Thr Ser Gly Lys Asp
                165                 170                 175     
Val Phe Gln Lys Lys Lys Leu Gly Cys Gln Leu Leu Gly Lys Tyr Lys
            180                 185                 190         
Gln Ile Ile Ala Val Leu Ala Gln Ala Phe
        195                 200         


<210> 446
<211> 1588
<212> PRT
<213> Homo sapiens

<400> 446
Met Val Gln Lys Lys Lys Phe Cys Pro Arg Leu Leu Asp Tyr Leu Val
 1               5                  10                  15      
Ile Val Gly Ala Arg His Pro Ser Ser Asp Ser Val Ala Gln Thr Pro
            20                  25                  30          
Glu Leu Leu Arg Arg Tyr Pro Leu Glu Asp His Thr Glu Phe Pro Leu
        35                  40                  45              
Pro Pro Asp Val Val Phe Phe Cys Gln Pro Glu Gly Cys Leu Ser Val
    50                  55                  60                  
Arg Gln Arg Arg Met Ser Leu Arg Asp Asp Thr Ser Phe Val Phe Thr
65                  70                  75                  80  
Leu Thr Asp Lys Asp Thr Gly Val Thr Arg Tyr Gly Ile Cys Val Asn
                85                  90                  95      
Phe Tyr Arg Ser Phe Gln Lys Arg Ile Ser Lys Glu Lys Gly Glu Gly
            100                 105                 110         
Gly Ala Gly Ser Arg Gly Lys Glu Gly Thr His Ala Thr Cys Ala Ser
        115                 120                 125             
Glu Glu Gly Gly Thr Glu Ser Ser Glu Ser Gly Ser Ser Leu Gln Pro
    130                 135                 140                 
Leu Ser Ala Asp Ser Thr Pro Asp Val Asn Gln Ser Pro Arg Gly Lys
145                 150                 155                 160 
Arg Arg Ala Lys Ala Gly Ser Arg Ser Arg Asn Ser Thr Leu Thr Ser
                165                 170                 175     
Leu Cys Val Leu Ser His Tyr Pro Phe Phe Ser Thr Phe Arg Glu Cys
            180                 185                 190         
Leu Tyr Thr Leu Lys Arg Leu Val Asp Cys Cys Ser Glu Arg Leu Leu
        195                 200                 205             
Gly Lys Lys Leu Gly Ile Pro Arg Gly Val Gln Arg Asp Thr Met Trp
    210                 215                 220                 
Arg Ile Phe Thr Gly Ser Leu Leu Val Glu Glu Lys Ser Ser Ala Leu
225                 230                 235                 240 
Leu His Asp Leu Arg Glu Ile Glu Ala Trp Ile Tyr Arg Leu Leu Arg
                245                 250                 255     
Ser Pro Val Pro Val Ser Gly Gln Lys Arg Val Asp Ile Glu Val Leu
            260                 265                 270         
Pro Gln Glu Leu Gln Pro Ala Leu Thr Phe Ala Leu Pro Asp Pro Ser
        275                 280                 285             
Arg Phe Thr Leu Val Asp Phe Pro Leu His Leu Pro Leu Glu Leu Leu
    290                 295                 300                 
Gly Val Asp Ala Cys Leu Gln Val Leu Thr Cys Ile Leu Leu Glu His
305                 310                 315                 320 
Lys Val Val Leu Gln Ser Arg Asp Tyr Asn Ala Leu Ser Met Ser Val
                325                 330                 335     
Met Ala Phe Val Ala Met Ile Tyr Pro Leu Glu Tyr Met Phe Pro Val
            340                 345                 350         
Ile Pro Leu Leu Pro Thr Cys Met Ala Ser Ala Glu Gln Leu Leu Leu
        355                 360                 365             
Ala Pro Thr Pro Tyr Ile Ile Gly Val Pro Ala Ser Phe Phe Leu Tyr
    370                 375                 380                 
Lys Leu Asp Phe Lys Met Pro Asp Asp Val Trp Leu Val Asp Leu Asp
385                 390                 395                 400 
Ser Asn Arg Val Ile Ala Pro Thr Asn Ala Glu Val Leu Pro Ile Leu
                405                 410                 415     
Pro Glu Pro Glu Ser Leu Glu Leu Lys Lys His Leu Lys Gln Ala Leu
            420                 425                 430         
Ala Ser Met Ser Leu Asn Thr Gln Pro Ile Leu Asn Leu Glu Lys Phe
        435                 440                 445             
His Glu Gly Gln Glu Ile Pro Leu Leu Leu Gly Arg Pro Ser Asn Asp
    450                 455                 460                 
Leu Gln Ser Thr Pro Ser Thr Glu Phe Asn Pro Leu Ile Tyr Gly Asn
465                 470                 475                 480 
Asp Val Asp Ser Val Asp Val Ala Thr Arg Val Ala Met Val Arg Phe
                485                 490                 495     
Phe Asn Ser Ala Asn Val Leu Gln Gly Phe Gln Met His Thr Arg Thr
            500                 505                 510         
Leu Arg Leu Phe Pro Arg Pro Val Val Ala Phe Gln Ala Gly Ser Phe
        515                 520                 525             
Leu Ala Ser Arg Pro Arg Gln Thr Pro Phe Ala Glu Lys Leu Ala Arg
    530                 535                 540                 
Thr Gln Ala Val Glu Tyr Phe Gly Glu Trp Ile Leu Asn Pro Thr Asn
545                 550                 555                 560 
Tyr Ala Phe Gln Arg Ile His Asn Asn Met Phe Asp Pro Ala Leu Ile
                565                 570                 575     
Gly Asp Lys Pro Lys Trp Tyr Ala His Gln Leu Gln Pro Ile His Tyr
            580                 585                 590         
Arg Val Tyr Asp Ser Asn Ser Gln Leu Ala Glu Ala Leu Ser Val Pro
        595                 600                 605             
Pro Glu Arg Asp Ser Asp Ser Glu Pro Thr Asp Asp Ser Gly Ser Asp
    610                 615                 620                 
Ser Met Asp Tyr Asp Asp Ser Ser Ser Ser Tyr Ser Ser Leu Gly Asp
625                 630                 635                 640 
Phe Val Ser Glu Met Met Lys Cys Asp Ile Asn Gly Asp Thr Pro Asn
                645                 650                 655     
Val Asp Pro Leu Thr His Ala Ala Leu Gly Asp Ala Ser Glu Val Glu
            660                 665                 670         
Ile Asp Glu Leu Gln Asn Gln Lys Glu Ala Glu Glu Pro Gly Pro Asp
        675                 680                 685             
Ser Glu Asn Ser Gln Glu Asn Pro Pro Leu Arg Ser Ser Ser Ser Thr
    690                 695                 700                 
Thr Ala Ser Ser Ser Pro Ser Thr Val Ile His Gly Ala Asn Ser Glu
705                 710                 715                 720 
Pro Ala Asp Ser Thr Glu Met Asp Asp Lys Ala Ala Val Gly Val Ser
                725                 730                 735     
Lys Pro Leu Pro Ser Val Pro Pro Ser Ile Gly Lys Ser Asn Met Asp
            740                 745                 750         
Arg Arg Gln Ala Glu Ile Gly Glu Gly Ser Val Arg Arg Arg Ile Tyr
        755                 760                 765             
Asp Asn Pro Tyr Phe Glu Pro Gln Tyr Gly Phe Pro Pro Glu Glu Asp
    770                 775                 780                 
Glu Asp Glu Gln Gly Glu Ser Tyr Thr Pro Arg Phe Ser Gln His Val
785                 790                 795                 800 
Ser Gly Asn Arg Ala Gln Lys Leu Leu Arg Pro Asn Ser Leu Arg Leu
                805                 810                 815     
Ala Ser Asp Ser Asp Ala Glu Ser Asp Ser Arg Ala Ser Ser Pro Asn
            820                 825                 830         
Ser Thr Val Ser Asn Thr Ser Thr Glu Gly Phe Gly Gly Ile Met Ser
        835                 840                 845             
Phe Ala Ser Ser Leu Tyr Arg Asn His Ser Thr Ser Phe Ser Leu Ser
    850                 855                 860                 
Asn Leu Thr Leu Pro Thr Lys Gly Ala Arg Glu Lys Ala Thr Pro Phe
865                 870                 875                 880 
Pro Ser Leu Lys Gly Asn Arg Arg Ala Leu Val Asp Gln Lys Ser Ser
                885                 890                 895     
Val Ile Lys His Ser Pro Thr Val Lys Arg Glu Pro Pro Ser Pro Gln
            900                 905                 910         
Gly Arg Ser Ser Asn Ser Ser Glu Asn Gln Gln Phe Leu Lys Glu Val
        915                 920                 925             
Val His Ser Val Leu Asp Gly Gln Gly Val Gly Trp Leu Asn Met Lys
    930                 935                 940                 
Lys Val Arg Arg Leu Leu Glu Ser Glu Gln Leu Arg Val Phe Val Leu
945                 950                 955                 960 
Ser Lys Leu Asn Arg Met Val Gln Ser Glu Asp Asp Ala Arg Gln Asp
                965                 970                 975     
Ile Ile Pro Asp Val Glu Ile Ser Arg Lys Val Tyr Lys Gly Met Leu
            980                 985                 990         
Asp Leu Leu Lys Cys Thr Val Leu Ser Leu Glu Gln Ser Tyr Ala His
        995                 1000                1005            
Ala Gly Leu Gly Gly Met Ala Ser Ile Phe Gly Leu Leu Glu Ile Ala
    1010                1015                1020                
Gln Thr His Tyr Tyr Ser Lys Glu Pro Asp Lys Arg Lys Arg Ser Pro
1025                1030                1035                1040
Thr Glu Ser Val Asn Thr Pro Val Gly Lys Asp Pro Gly Leu Ala Gly
                1045                1050                1055    
Arg Gly Asp Pro Lys Ala Met Ala Gln Leu Arg Val Pro Gln Leu Gly
            1060                1065                1070        
Pro Arg Ala Pro Ser Ala Thr Gly Lys Gly Pro Lys Glu Leu Asp Thr
        1075                1080                1085            
Arg Ser Leu Lys Glu Glu Asn Phe Ile Ala Ser Ile Gly Pro Glu Val
    1090                1095                1100                
Ile Lys Pro Val Phe Asp Leu Gly Glu Thr Glu Glu Lys Lys Ser Gln
1105                1110                1115                1120
Ile Ser Ala Asp Ser Gly Val Ser Leu Thr Ser Ser Ser Gln Arg Thr
                1125                1130                1135    
Asp Gln Asp Ser Val Ile Gly Val Ser Pro Ala Val Met Ile Arg Ser
            1140                1145                1150        
Ser Ser Gln Asp Ser Glu Val Ser Thr Val Val Ser Asn Ser Ser Gly
        1155                1160                1165            
Glu Thr Leu Gly Ala Asp Ser Asp Leu Ser Ser Asn Ala Gly Asp Gly
    1170                1175                1180                
Pro Gly Gly Glu Gly Ser Val His Leu Ala Ser Ser Arg Gly Thr Leu
1185                1190                1195                1200
Ser Asp Ser Glu Ile Glu Thr Asn Ser Ala Thr Ser Thr Ile Phe Gly
                1205                1210                1215    
Lys Ala His Ser Leu Lys Pro Ser Ile Lys Glu Lys Leu Ala Gly Ser
            1220                1225                1230        
Pro Ile Arg Thr Ser Glu Asp Val Ser Gln Arg Val Tyr Leu Tyr Glu
        1235                1240                1245            
Gly Leu Leu Gly Lys Glu Arg Ser Thr Leu Trp Asp Gln Met Gln Phe
    1250                1255                1260                
Trp Glu Asp Ala Phe Leu Asp Ala Val Met Leu Glu Arg Glu Gly Met
1265                1270                1275                1280
Gly Met Asp Gln Gly Pro Gln Glu Met Ile Asp Arg Tyr Leu Ser Leu
                1285                1290                1295    
Gly Glu His Asp Arg Lys Arg Leu Glu Asp Asp Glu Asp Arg Leu Leu
            1300                1305                1310        
Ala Thr Leu Leu His Asn Leu Ile Ser Tyr Met Leu Leu Met Lys Val
        1315                1320                1325            
Asn Lys Asn Asp Ile Arg Lys Lys Val Arg Arg Leu Met Gly Lys Ser
    1330                1335                1340                
His Ile Gly Leu Val Tyr Ser Gln Gln Ile Asn Glu Val Leu Asp Gln
1345                1350                1355                1360
Leu Ala Asn Leu Asn Gly Arg Asp Leu Ser Ile Trp Ser Ser Gly Ser
                1365                1370                1375    
Arg His Met Lys Lys Gln Thr Phe Val Val His Ala Gly Thr Asp Thr
            1380                1385                1390        
Asn Gly Asp Ile Phe Phe Met Glu Val Cys Asp Asp Cys Val Val Leu
        1395                1400                1405            
Arg Ser Asn Ile Gly Thr Val Tyr Glu Arg Trp Trp Tyr Glu Lys Leu
    1410                1415                1420                
Ile Asn Met Thr Tyr Cys Pro Lys Thr Lys Val Leu Cys Leu Trp Arg
1425                1430                1435                1440
Arg Asn Gly Ser Glu Thr Gln Leu Asn Lys Phe Tyr Thr Lys Lys Cys
                1445                1450                1455    
Arg Glu Leu Tyr Tyr Cys Val Lys Asp Ser Met Glu Arg Ala Ala Ala
            1460                1465                1470        
Arg Gln Gln Ser Ile Lys Pro Gly Pro Glu Leu Gly Gly Glu Phe Pro
        1475                1480                1485            
Val Gln Asp Leu Lys Thr Gly Glu Gly Gly Leu Leu Gln Val Thr Leu
    1490                1495                1500                
Glu Gly Ile Asn Leu Lys Phe Met His Asn Gln Val Phe Ile Glu Leu
1505                1510                1515                1520
Asn His Ile Lys Lys Cys Asn Thr Val Arg Gly Val Phe Val Leu Glu
                1525                1530                1535    
Glu Phe Val Pro Glu Ile Lys Glu Val Val Ser His Lys Tyr Lys Thr
            1540                1545                1550        
Pro Met Ala His Glu Ile Cys Tyr Ser Val Leu Cys Leu Phe Ser Tyr
        1555                1560                1565            
Val Ala Ala Val His Ser Ser Glu Glu Asp Leu Arg Thr Pro Pro Arg
    1570                1575                1580                
Pro Val Ser Ser
1585            


<210> 447
<211> 520
<212> PRT
<213> Homo sapiens

<400> 447
Met Ser Asn Lys Cys Asp Val Val Val Val Gly Gly Gly Ile Ser Gly
 1               5                  10                  15      
Met Ala Ala Ala Lys Leu Leu His Asp Ser Gly Leu Asn Val Val Val
            20                  25                  30          
Leu Glu Ala Arg Asp Arg Val Gly Gly Arg Thr Tyr Thr Leu Arg Asn
        35                  40                  45              
Gln Lys Val Lys Tyr Val Asp Leu Gly Gly Ser Tyr Val Gly Pro Thr
    50                  55                  60                  
Gln Asn Arg Ile Leu Arg Leu Ala Lys Glu Leu Gly Leu Glu Thr Tyr
65                  70                  75                  80  
Lys Val Asn Glu Val Glu Arg Leu Ile His His Val Lys Gly Lys Ser
                85                  90                  95      
Tyr Pro Phe Arg Gly Pro Phe Pro Pro Val Trp Asn Pro Ile Thr Tyr
            100                 105                 110         
Leu Asp His Asn Asn Phe Trp Arg Thr Met Asp Asp Met Gly Arg Glu
        115                 120                 125             
Ile Pro Ser Asp Ala Pro Trp Lys Ala Pro Leu Ala Glu Glu Trp Asp
    130                 135                 140                 
Asn Met Thr Met Lys Glu Leu Leu Asp Lys Leu Cys Trp Thr Glu Ser
145                 150                 155                 160 
Ala Lys Gln Leu Ala Thr Leu Phe Val Asn Leu Cys Val Thr Ala Glu
                165                 170                 175     
Thr His Glu Val Ser Ala Leu Trp Phe Leu Trp Tyr Val Lys Gln Cys
            180                 185                 190         
Gly Gly Thr Thr Arg Ile Ile Ser Thr Thr Asn Gly Gly Gln Glu Arg
        195                 200                 205             
Lys Phe Val Gly Gly Ser Gly Gln Val Ser Glu Arg Ile Met Asp Leu
    210                 215                 220                 
Leu Gly Asp Arg Val Lys Leu Glu Arg Pro Val Ile Tyr Ile Asp Gln
225                 230                 235                 240 
Thr Arg Glu Asn Val Leu Val Glu Thr Leu Asn His Glu Met Tyr Glu
                245                 250                 255     
Ala Lys Tyr Val Ile Ser Ala Ile Pro Pro Thr Leu Gly Met Lys Ile
            260                 265                 270         
His Phe Asn Pro Pro Leu Pro Met Met Arg Asn Gln Met Ile Thr Arg
        275                 280                 285             
Val Pro Leu Gly Ser Val Ile Lys Cys Ile Val Tyr Tyr Lys Glu Pro
    290                 295                 300                 
Phe Trp Arg Lys Lys Asp Tyr Cys Gly Thr Met Ile Ile Asp Gly Glu
305                 310                 315                 320 
Glu Ala Pro Val Ala Tyr Thr Leu Asp Asp Thr Lys Pro Glu Gly Asn
                325                 330                 335     
Tyr Ala Ala Ile Met Gly Phe Ile Leu Ala His Lys Ala Arg Lys Leu
            340                 345                 350         
Ala Arg Leu Thr Lys Glu Glu Arg Leu Lys Lys Leu Cys Glu Leu Tyr
        355                 360                 365             
Ala Lys Val Leu Gly Ser Leu Glu Ala Leu Glu Pro Val His Tyr Glu
    370                 375                 380                 
Glu Lys Asn Trp Cys Glu Glu Gln Tyr Ser Gly Gly Cys Tyr Thr Thr
385                 390                 395                 400 
Tyr Phe Pro Pro Gly Ile Leu Thr Gln Tyr Gly Arg Val Leu Arg Gln
                405                 410                 415     
Pro Val Asp Arg Ile Tyr Phe Ala Gly Thr Glu Thr Ala Thr His Trp
            420                 425                 430         
Ser Gly Tyr Met Glu Gly Ala Val Glu Ala Gly Glu Arg Ala Ala Arg
        435                 440                 445             
Glu Ile Leu His Ala Met Gly Lys Ile Pro Glu Asp Glu Ile Trp Gln
    450                 455                 460                 
Ser Glu Pro Glu Ser Val Asp Val Pro Ala Gln Pro Ile Thr Thr Thr
465                 470                 475                 480 
Phe Leu Glu Arg His Leu Pro Ser Val Pro Gly Leu Leu Arg Leu Ile
                485                 490                 495     
Gly Leu Thr Thr Ile Phe Ser Ala Thr Ala Leu Gly Phe Leu Ala His
            500                 505                 510         
Lys Arg Gly Leu Leu Val Arg Val
        515                 520 


<210> 448
<211> 520
<212> PRT
<213> Homo sapiens

<400> 448
Met Ser Asn Lys Cys Asp Val Val Val Val Gly Gly Gly Ile Ser Gly
 1               5                  10                  15      
Met Ala Ala Ala Lys Leu Leu His Asp Ser Gly Leu Asn Val Val Val
            20                  25                  30          
Leu Glu Ala Arg Asp Arg Val Gly Gly Arg Thr Tyr Thr Leu Arg Asn
        35                  40                  45              
Gln Lys Val Lys Tyr Val Asp Leu Gly Gly Ser Tyr Val Gly Pro Thr
    50                  55                  60                  
Gln Asn Arg Ile Leu Arg Leu Ala Lys Glu Leu Gly Leu Glu Thr Tyr
65                  70                  75                  80  
Lys Val Asn Glu Val Glu Arg Leu Ile His His Val Lys Gly Lys Ser
                85                  90                  95      
Tyr Pro Phe Arg Gly Pro Phe Pro Pro Val Trp Asn Pro Ile Thr Tyr
            100                 105                 110         
Leu Asp His Asn Asn Phe Trp Arg Thr Met Asp Asp Met Gly Arg Glu
        115                 120                 125             
Ile Pro Ser Asp Ala Pro Trp Lys Ala Pro Leu Ala Glu Glu Trp Asp
    130                 135                 140                 
Asn Met Thr Met Lys Glu Leu Leu Asp Lys Leu Cys Trp Thr Glu Ser
145                 150                 155                 160 
Ala Lys Gln Leu Ala Thr Leu Phe Val Asn Leu Cys Val Thr Ala Glu
                165                 170                 175     
Thr His Glu Val Ser Ala Leu Trp Phe Leu Trp Tyr Val Lys Gln Cys
            180                 185                 190         
Gly Gly Thr Thr Arg Ile Ile Ser Thr Thr Asn Gly Gly Gln Glu Arg
        195                 200                 205             
Lys Phe Val Gly Gly Ser Gly Gln Val Ser Glu Arg Ile Met Asp Leu
    210                 215                 220                 
Leu Gly Asp Arg Val Lys Leu Glu Arg Pro Val Ile Tyr Ile Asp Gln
225                 230                 235                 240 
Thr Arg Glu Asn Val Leu Val Glu Thr Leu Asn His Glu Met Tyr Glu
                245                 250                 255     
Ala Lys Tyr Val Ile Ser Ala Ile Pro Pro Thr Leu Gly Met Lys Ile
            260                 265                 270         
His Phe Asn Pro Pro Leu Pro Met Met Arg Asn Gln Met Ile Thr Arg
        275                 280                 285             
Val Pro Leu Gly Ser Val Ile Lys Cys Ile Val Tyr Tyr Lys Glu Pro
    290                 295                 300                 
Phe Trp Arg Lys Lys Asp Tyr Cys Gly Thr Met Ile Ile Asp Gly Glu
305                 310                 315                 320 
Glu Ala Pro Val Ala Tyr Thr Leu Asp Asp Thr Lys Pro Glu Gly Asn
                325                 330                 335     
Tyr Ala Ala Ile Met Gly Phe Ile Leu Ala His Lys Ala Arg Lys Leu
            340                 345                 350         
Ala Arg Leu Thr Lys Glu Glu Arg Leu Lys Lys Leu Cys Glu Leu Tyr
        355                 360                 365             
Ala Lys Val Leu Gly Ser Leu Glu Ala Leu Glu Pro Val His Tyr Glu
    370                 375                 380                 
Glu Lys Asn Trp Cys Glu Glu Gln Tyr Ser Gly Gly Cys Tyr Thr Thr
385                 390                 395                 400 
Tyr Phe Pro Pro Gly Ile Leu Thr Gln Tyr Gly Arg Val Leu Arg Gln
                405                 410                 415     
Pro Val Asp Arg Ile Tyr Phe Ala Gly Thr Glu Thr Ala Thr His Trp
            420                 425                 430         
Ser Gly Tyr Met Glu Gly Ala Val Glu Ala Gly Glu Arg Ala Ala Arg
        435                 440                 445             
Glu Ile Leu His Ala Met Gly Lys Ile Pro Glu Asp Glu Ile Trp Gln
    450                 455                 460                 
Ser Glu Pro Glu Ser Val Asp Val Pro Ala Gln Pro Ile Thr Thr Thr
465                 470                 475                 480 
Phe Leu Glu Arg His Leu Pro Ser Val Pro Gly Leu Leu Arg Leu Ile
                485                 490                 495     
Gly Leu Thr Thr Ile Phe Ser Ala Thr Ala Leu Gly Phe Leu Ala His
            500                 505                 510         
Lys Arg Gly Leu Leu Val Arg Val
        515                 520 


<210> 449
<211> 584
<212> PRT
<213> Homo sapiens

<400> 449
Met Leu Ser Arg Leu Arg Val Val Ser Thr Thr Cys Thr Leu Ala Cys
 1               5                  10                  15      
Arg His Leu His Ile Lys Glu Lys Gly Lys Pro Leu Met Leu Asn Pro
            20                  25                  30          
Arg Thr Asn Lys Gly Met Ala Phe Thr Leu Gln Glu Arg Gln Met Leu
        35                  40                  45              
Gly Leu Gln Gly Leu Leu Pro Pro Lys Ile Glu Thr Gln Asp Ile Gln
    50                  55                  60                  
Ala Leu Arg Phe His Arg Asn Leu Lys Lys Met Thr Ser Pro Leu Glu
65                  70                  75                  80  
Lys Tyr Ile Tyr Ile Met Gly Ile Gln Glu Arg Asn Glu Lys Leu Phe
                85                  90                  95      
Tyr Arg Ile Leu Gln Asp Asp Ile Glu Ser Leu Met Pro Ile Val Tyr
            100                 105                 110         
Thr Pro Thr Val Gly Leu Ala Cys Ser Gln Tyr Gly His Ile Phe Arg
        115                 120                 125             
Arg Pro Lys Gly Leu Phe Ile Ser Ile Ser Asp Arg Gly His Val Arg
    130                 135                 140                 
Ser Ile Val Asp Asn Trp Pro Glu Asn His Val Lys Ala Val Val Val
145                 150                 155                 160 
Thr Asp Gly Glu Arg Ile Leu Gly Leu Gly Asp Leu Gly Val Tyr Gly
                165                 170                 175     
Met Gly Ile Pro Val Gly Lys Leu Cys Leu Tyr Thr Ala Cys Ala Gly
            180                 185                 190         
Ile Arg Pro Asp Arg Cys Leu Pro Val Cys Ile Asp Val Gly Thr Asp
        195                 200                 205             
Asn Ile Ala Leu Leu Lys Asp Pro Phe Tyr Met Gly Leu Tyr Gln Lys
    210                 215                 220                 
Arg Asp Arg Thr Gln Gln Tyr Asp Asp Leu Ile Asp Glu Phe Met Lys
225                 230                 235                 240 
Ala Ile Thr Asp Arg Tyr Gly Arg Asn Thr Leu Ile Gln Phe Glu Asp
                245                 250                 255     
Phe Gly Asn His Asn Ala Phe Arg Phe Leu Arg Lys Tyr Arg Glu Lys
            260                 265                 270         
Tyr Cys Thr Phe Asn Asp Asp Ile Gln Gly Thr Ala Ala Val Ala Leu
        275                 280                 285             
Ala Gly Leu Leu Ala Ala Gln Lys Val Ile Ser Lys Pro Ile Ser Glu
    290                 295                 300                 
His Lys Ile Leu Phe Leu Gly Ala Gly Glu Ala Ala Leu Gly Ile Ala
305                 310                 315                 320 
Asn Leu Ile Val Met Ser Met Val Glu Asn Gly Leu Ser Glu Gln Glu
                325                 330                 335     
Ala Gln Lys Lys Ile Trp Met Phe Asp Lys Tyr Gly Leu Leu Val Lys
            340                 345                 350         
Gly Arg Lys Ala Lys Ile Asp Ser Tyr Gln Glu Pro Phe Thr His Ser
        355                 360                 365             
Ala Pro Glu Ser Ile Pro Asp Thr Phe Glu Asp Ala Val Asn Ile Leu
    370                 375                 380                 
Lys Pro Ser Thr Ile Ile Gly Val Ala Gly Ala Gly Arg Leu Phe Thr
385                 390                 395                 400 
Pro Asp Val Ile Arg Ala Met Ala Ser Ile Asn Glu Arg Pro Val Ile
                405                 410                 415     
Phe Ala Leu Ser Asn Pro Thr Ala Gln Ala Glu Cys Thr Ala Glu Glu
            420                 425                 430         
Ala Tyr Thr Leu Thr Glu Gly Arg Cys Leu Phe Ala Ser Gly Ser Pro
        435                 440                 445             
Phe Gly Pro Val Lys Leu Thr Asp Gly Arg Val Phe Thr Pro Gly Gln
    450                 455                 460                 
Gly Asn Asn Val Tyr Ile Phe Pro Gly Val Ala Leu Ala Val Ile Leu
465                 470                 475                 480 
Cys Asn Thr Arg His Ile Ser Asp Ser Val Phe Leu Glu Ala Ala Lys
                485                 490                 495     
Ala Leu Thr Ser Gln Leu Thr Asp Glu Glu Leu Ala Gln Gly Arg Leu
            500                 505                 510         
Tyr Pro Pro Leu Ala Asn Ile Gln Glu Val Ser Ile Asn Ile Ala Ile
        515                 520                 525             
Lys Val Thr Glu Tyr Leu Tyr Ala Asn Lys Met Ala Phe Arg Tyr Pro
    530                 535                 540                 
Glu Pro Glu Asp Lys Ala Lys Tyr Val Lys Glu Arg Thr Trp Arg Ser
545                 550                 555                 560 
Glu Tyr Asp Ser Leu Leu Pro Asp Val Tyr Glu Trp Pro Glu Ser Ala
                565                 570                 575     
Ser Ser Pro Pro Val Ile Thr Glu
            580                 


<210> 450
<211> 584
<212> PRT
<213> Homo sapiens

<400> 450
Met Leu Ser Arg Leu Arg Val Val Ser Thr Thr Cys Thr Leu Ala Cys
 1               5                  10                  15      
Arg His Leu His Ile Lys Glu Lys Gly Lys Pro Leu Met Leu Asn Pro
            20                  25                  30          
Arg Thr Asn Lys Gly Met Ala Phe Thr Leu Gln Glu Arg Gln Met Leu
        35                  40                  45              
Gly Leu Gln Gly Leu Leu Pro Pro Lys Ile Glu Thr Gln Asp Ile Gln
    50                  55                  60                  
Ala Leu Arg Phe His Arg Asn Leu Lys Lys Met Thr Ser Pro Leu Glu
65                  70                  75                  80  
Lys Tyr Ile Tyr Ile Met Gly Ile Gln Glu Arg Asn Glu Lys Leu Phe
                85                  90                  95      
Tyr Arg Ile Leu Gln Asp Asp Ile Glu Ser Leu Met Pro Ile Val Tyr
            100                 105                 110         
Thr Pro Thr Val Gly Leu Ala Cys Ser Gln Tyr Gly His Ile Phe Arg
        115                 120                 125             
Arg Pro Lys Gly Leu Phe Ile Ser Ile Ser Asp Arg Gly His Val Arg
    130                 135                 140                 
Ser Ile Val Asp Asn Trp Pro Glu Asn His Val Lys Ala Val Val Val
145                 150                 155                 160 
Thr Asp Gly Glu Arg Ile Leu Gly Leu Gly Asp Leu Gly Val Tyr Gly
                165                 170                 175     
Met Gly Ile Pro Val Gly Lys Leu Cys Leu Tyr Thr Ala Cys Ala Gly
            180                 185                 190         
Ile Arg Pro Asp Arg Cys Leu Pro Val Cys Ile Asp Val Gly Thr Asp
        195                 200                 205             
Asn Ile Ala Leu Leu Lys Asp Pro Phe Tyr Met Gly Leu Tyr Gln Lys
    210                 215                 220                 
Arg Asp Arg Thr Gln Gln Tyr Asp Asp Leu Ile Asp Glu Phe Met Lys
225                 230                 235                 240 
Ala Ile Thr Asp Arg Tyr Gly Arg Asn Thr Leu Ile Gln Phe Glu Asp
                245                 250                 255     
Phe Gly Asn His Asn Ala Phe Arg Phe Leu Arg Lys Tyr Arg Glu Lys
            260                 265                 270         
Tyr Cys Thr Phe Asn Asp Asp Ile Gln Gly Thr Ala Ala Val Ala Leu
        275                 280                 285             
Ala Gly Leu Leu Ala Ala Gln Lys Val Ile Ser Lys Pro Ile Ser Glu
    290                 295                 300                 
His Lys Ile Leu Phe Leu Gly Ala Gly Glu Ala Ala Leu Gly Ile Ala
305                 310                 315                 320 
Asn Leu Ile Val Met Ser Met Val Glu Asn Gly Leu Ser Glu Gln Glu
                325                 330                 335     
Ala Gln Lys Lys Ile Trp Met Phe Asp Lys Tyr Gly Leu Leu Val Lys
            340                 345                 350         
Gly Arg Lys Ala Lys Ile Asp Ser Tyr Gln Glu Pro Phe Thr His Ser
        355                 360                 365             
Ala Pro Glu Ser Ile Pro Asp Thr Phe Glu Asp Ala Val Asn Ile Leu
    370                 375                 380                 
Lys Pro Ser Thr Ile Ile Gly Val Ala Gly Ala Gly Arg Leu Phe Thr
385                 390                 395                 400 
Pro Asp Val Ile Arg Ala Met Ala Ser Ile Asn Glu Arg Pro Val Ile
                405                 410                 415     
Phe Ala Leu Ser Asn Pro Thr Ala Gln Ala Glu Cys Thr Ala Glu Glu
            420                 425                 430         
Ala Tyr Thr Leu Thr Glu Gly Arg Cys Leu Phe Ala Ser Gly Ser Pro
        435                 440                 445             
Phe Gly Pro Val Lys Leu Thr Asp Gly Arg Val Phe Thr Pro Gly Gln
    450                 455                 460                 
Gly Asn Asn Val Tyr Ile Phe Pro Gly Val Ala Leu Ala Val Ile Leu
465                 470                 475                 480 
Cys Asn Thr Arg His Ile Ser Asp Ser Val Phe Leu Glu Ala Ala Lys
                485                 490                 495     
Ala Leu Thr Ser Gln Leu Thr Asp Glu Glu Leu Ala Gln Gly Arg Leu
            500                 505                 510         
Tyr Pro Pro Leu Ala Asn Ile Gln Glu Val Ser Ile Asn Ile Ala Ile
        515                 520                 525             
Lys Val Thr Glu Tyr Leu Tyr Ala Asn Lys Met Ala Phe Arg Tyr Pro
    530                 535                 540                 
Glu Pro Glu Asp Lys Ala Lys Tyr Val Lys Glu Arg Thr Trp Arg Ser
545                 550                 555                 560 
Glu Tyr Asp Ser Leu Leu Pro Asp Val Tyr Glu Trp Pro Glu Ser Ala
                565                 570                 575     
Ser Ser Pro Pro Val Ile Thr Glu
            580                 


<210> 451
<211> 626
<212> PRT
<213> Homo sapiens

<400> 451
Met Asp Glu Gln Glu Ala Leu Asn Ser Ile Met Asn Asp Leu Val Ala
 1               5                  10                  15      
Leu Gln Met Asn Arg Arg His Arg Met Pro Gly Tyr Glu Thr Met Lys
            20                  25                  30          
Asn Lys Asp Thr Gly His Ser Asn Arg Gln Ser Asp Val Arg Ile Lys
        35                  40                  45              
Phe Glu His Asn Gly Glu Arg Arg Ile Ile Ala Phe Ser Arg Pro Val
    50                  55                  60                  
Lys Tyr Glu Asp Val Glu His Lys Val Thr Thr Val Phe Gly Gln Pro
65                  70                  75                  80  
Leu Asp Leu His Tyr Met Asn Asn Glu Leu Ser Ile Leu Leu Lys Asn
                85                  90                  95      
Gln Asp Asp Leu Asp Lys Ala Ile Asp Ile Leu Asp Arg Ser Ser Ser
            100                 105                 110         
Met Lys Ser Leu Arg Ile Leu Leu Leu Ser Gln Asp Arg Asn His Asn
        115                 120                 125             
Ser Ser Ser Pro His Ser Glu Val Ser Arg Gln Val Arg Ile Lys Ala
    130                 135                 140                 
Ser Gln Ser Ala Gly Asp Ile Asn Thr Ile Tyr Gln Pro Pro Glu Pro
145                 150                 155                 160 
Arg Ser Arg His Leu Ser Val Ser Ser Gln Asn Pro Gly Arg Ser Ser
                165                 170                 175     
Pro Pro Pro Gly Tyr Val Pro Glu Arg Gln Gln His Ile Ala Arg Gln
            180                 185                 190         
Gly Ser Tyr Thr Ser Ile Asn Ser Glu Gly Glu Phe Ile Pro Glu Thr
        195                 200                 205             
Ser Glu Gln Cys Met Leu Asp Pro Leu Ser Ser Ala Glu Asn Ser Leu
    210                 215                 220                 
Ser Gly Ser Cys Gln Ser Leu Asp Arg Ser Ala Asp Ser Pro Ser Phe
225                 230                 235                 240 
Arg Lys Ser Arg Met Ser Arg Ala Gln Ser Phe Pro Asp Asn Arg Gln
                245                 250                 255     
Glu Tyr Ser Asp Arg Glu Thr Gln Leu Tyr Asp Lys Gly Val Lys Gly
            260                 265                 270         
Gly Thr Tyr Pro Arg Arg Tyr His Val Ser Val His His Lys Asp Tyr
        275                 280                 285             
Ser Asp Gly Arg Arg Thr Phe Pro Arg Ile Arg Arg His Gln Gly Asn
    290                 295                 300                 
Leu Phe Thr Leu Val Pro Ser Ser Arg Ser Leu Ser Thr Asn Gly Glu
305                 310                 315                 320 
Asn Met Gly Leu Ala Val Gln Tyr Leu Asp Pro Arg Gly Arg Leu Arg
                325                 330                 335     
Ser Ala Asp Ser Glu Asn Ala Leu Ser Val Gln Glu Arg Asn Val Pro
            340                 345                 350         
Thr Lys Ser Pro Ser Ala Pro Ile Asn Trp Arg Arg Gly Lys Leu Leu
        355                 360                 365             
Gly Gln Gly Ala Phe Gly Arg Val Tyr Leu Cys Tyr Asp Val Asp Thr
    370                 375                 380                 
Gly Arg Glu Leu Ala Ser Lys Gln Val Gln Phe Asp Pro Asp Ser Pro
385                 390                 395                 400 
Glu Thr Ser Lys Glu Val Ser Ala Leu Glu Cys Glu Ile Gln Leu Leu
                405                 410                 415     
Lys Asn Leu Gln His Glu Arg Ile Val Gln Tyr Tyr Gly Cys Leu Arg
            420                 425                 430         
Asp Arg Ala Glu Lys Thr Leu Thr Ile Phe Met Glu Tyr Met Pro Gly
        435                 440                 445             
Gly Ser Val Lys Asp Gln Leu Lys Ala Tyr Gly Ala Leu Thr Glu Ser
    450                 455                 460                 
Val Thr Arg Lys Tyr Thr Arg Gln Ile Leu Glu Gly Met Ser Tyr Leu
465                 470                 475                 480 
His Ser Asn Met Ile Val His Arg Asp Ile Lys Gly Ala Asn Ile Leu
                485                 490                 495     
Arg Asp Ser Ala Gly Asn Val Lys Leu Gly Asp Phe Gly Ala Ser Lys
            500                 505                 510         
Arg Leu Gln Thr Ile Cys Met Ser Gly Thr Gly Met Arg Ser Val Thr
        515                 520                 525             
Gly Thr Pro Tyr Trp Met Ser Pro Glu Val Ile Ser Gly Glu Gly Tyr
    530                 535                 540                 
Gly Arg Lys Ala Asp Val Trp Ser Leu Gly Cys Thr Val Val Glu Met
545                 550                 555                 560 
Leu Thr Glu Lys Pro Pro Trp Ala Glu Tyr Glu Ala Met Ala Ala Ile
                565                 570                 575     
Phe Lys Ile Ala Thr Gln Pro Thr Asn Pro Gln Leu Pro Ser His Ile
            580                 585                 590         
Ser Glu His Gly Arg Asp Phe Leu Arg Arg Ile Phe Val Glu Ala Arg
        595                 600                 605             
Gln Arg Pro Ser Ala Glu Glu Leu Leu Thr His His Phe Ala Gln Leu
    610                 615                 620                 
Met Tyr
625     


<210> 452
<211> 1128
<212> PRT
<213> Homo sapiens

<400> 452
Met Ser Arg Arg Lys Pro Ala Ser Gly Gly Leu Ala Ala Ser Ser Ser
 1               5                  10                  15      
Ala Pro Ala Arg Gln Ala Val Leu Ser Arg Phe Phe Gln Ser Thr Gly
            20                  25                  30          
Ser Leu Lys Ser Thr Ser Ser Ser Thr Gly Ala Ala Asp Gln Val Asp
        35                  40                  45              
Pro Gly Ala Ala Ala Ala Ala Ala Pro Pro Ala Pro Ala Phe Pro Pro
    50                  55                  60                  
Gln Leu Pro Pro His Val Ala Thr Glu Ile Asp Arg Arg Lys Lys Arg
65                  70                  75                  80  
Pro Leu Glu Asn Asp Gly Pro Val Lys Lys Lys Val Lys Lys Val Gln
                85                  90                  95      
Gln Lys Glu Gly Gly Ser Asp Leu Gly Met Ser Gly Asn Ser Glu Pro
            100                 105                 110         
Lys Lys Cys Leu Arg Thr Arg Asn Val Ser Lys Ser Leu Glu Lys Leu
        115                 120                 125             
Lys Glu Phe Cys Cys Asp Ser Ala Leu Pro Gln Ser Arg Val Gln Thr
    130                 135                 140                 
Glu Ser Leu Gln Glu Arg Phe Ala Val Leu Pro Lys Cys Thr Asp Phe
145                 150                 155                 160 
Asp Asp Ile Ser Leu Leu His Ala Lys Asn Ala Val Ser Ser Glu Asp
                165                 170                 175     
Ser Lys Arg Gln Ile Asn Gln Lys Asp Thr Thr Leu Phe Asp Leu Ser
            180                 185                 190         
Gln Phe Gly Ser Ser Asn Thr Ser His Glu Asn Leu Gln Lys Thr Ala
        195                 200                 205             
Ser Lys Ser Ala Asn Lys Arg Ser Lys Ser Ile Tyr Thr Pro Leu Glu
    210                 215                 220                 
Leu Gln Tyr Ile Glu Met Lys Gln Gln His Lys Asp Ala Val Leu Cys
225                 230                 235                 240 
Val Glu Cys Gly Tyr Lys Tyr Arg Phe Phe Gly Glu Asp Ala Glu Ile
                245                 250                 255     
Ala Ala Arg Glu Leu Asn Ile Tyr Cys His Leu Asp His Asn Phe Met
            260                 265                 270         
Thr Ala Ser Ile Pro Thr His Arg Leu Phe Val His Val Arg Arg Leu
        275                 280                 285             
Val Ala Lys Gly Tyr Lys Val Gly Val Val Lys Gln Thr Glu Thr Ala
    290                 295                 300                 
Ala Leu Lys Ala Ile Gly Asp Asn Arg Ser Ser Leu Phe Ser Arg Lys
305                 310                 315                 320 
Leu Thr Ala Leu Tyr Thr Lys Ser Thr Leu Ile Gly Glu Asp Val Asn
                325                 330                 335     
Pro Leu Ile Lys Leu Asp Asp Ala Val Asn Val Asp Glu Ile Met Thr
            340                 345                 350         
Asp Thr Ser Thr Ser Tyr Leu Leu Cys Ile Ser Glu Asn Lys Glu Asn
        355                 360                 365             
Val Arg Asp Lys Lys Lys Gly Asn Ile Phe Ile Gly Ile Val Gly Val
    370                 375                 380                 
Gln Pro Ala Thr Gly Glu Val Val Phe Asp Ser Phe Gln Asp Ser Ala
385                 390                 395                 400 
Ser Arg Ser Glu Leu Glu Thr Arg Met Ser Ser Leu Gln Pro Val Glu
                405                 410                 415     
Leu Leu Leu Pro Ser Ala Leu Ser Glu Gln Thr Glu Ala Leu Ile His
            420                 425                 430         
Arg Ala Thr Ser Val Ser Val Gln Asp Asp Arg Ile Arg Val Glu Arg
        435                 440                 445             
Met Asp Asn Ile Tyr Phe Glu Tyr Ser His Ala Phe Gln Ala Val Thr
    450                 455                 460                 
Glu Phe Tyr Ala Lys Asp Thr Val Asp Ile Lys Gly Ser Gln Ile Ile
465                 470                 475                 480 
Ser Gly Ile Val Asn Leu Glu Lys Pro Val Ile Cys Ser Leu Ala Ala
                485                 490                 495     
Ile Ile Lys Tyr Leu Lys Glu Phe Asn Leu Glu Lys Met Leu Ser Lys
            500                 505                 510         
Pro Glu Asn Phe Lys Gln Leu Ser Ser Lys Met Glu Phe Met Thr Ile
        515                 520                 525             
Asn Gly Thr Thr Leu Arg Asn Leu Glu Ile Leu Gln Asn Gln Thr Asp
    530                 535                 540                 
Met Lys Thr Lys Gly Ser Leu Leu Trp Val Leu Asp His Thr Lys Thr
545                 550                 555                 560 
Ser Phe Gly Arg Arg Lys Leu Lys Lys Trp Val Thr Gln Pro Leu Leu
                565                 570                 575     
Lys Leu Arg Glu Ile Asn Ala Arg Leu Asp Ala Val Ser Glu Val Leu
            580                 585                 590         
His Ser Glu Ser Ser Val Phe Gly Gln Ile Glu Asn His Leu Arg Lys
        595                 600                 605             
Leu Pro Asp Ile Glu Arg Gly Leu Cys Ser Ile Tyr His Lys Lys Cys
    610                 615                 620                 
Ser Thr Gln Glu Phe Phe Leu Ile Val Lys Thr Leu Tyr His Leu Lys
625                 630                 635                 640 
Ser Glu Phe Gln Ala Ile Ile Pro Ala Val Asn Ser His Ile Gln Ser
                645                 650                 655     
Asp Leu Leu Arg Thr Val Ile Leu Glu Ile Pro Glu Leu Leu Ser Pro
            660                 665                 670         
Val Glu His Tyr Leu Lys Ile Leu Asn Glu Gln Ala Ala Lys Val Gly
        675                 680                 685             
Asp Lys Thr Glu Leu Phe Lys Asp Leu Ser Asp Phe Pro Leu Ile Lys
    690                 695                 700                 
Lys Arg Lys Asp Glu Ile Gln Gly Val Ile Asp Glu Ile Arg Met His
705                 710                 715                 720 
Leu Gln Glu Ile Arg Lys Ile Leu Lys Asn Pro Ser Ala Gln Tyr Val
                725                 730                 735     
Thr Val Ser Gly Gln Glu Phe Met Ile Glu Ile Lys Asn Ser Ala Val
            740                 745                 750         
Ser Cys Ile Pro Thr Asp Trp Val Lys Val Gly Ser Thr Lys Ala Val
        755                 760                 765             
Ser Arg Phe His Ser Pro Phe Ile Val Glu Asn Tyr Arg His Leu Asn
    770                 775                 780                 
Gln Leu Arg Glu Gln Leu Val Leu Asp Cys Ser Ala Glu Trp Leu Asp
785                 790                 795                 800 
Phe Leu Glu Lys Phe Ser Glu His Tyr His Ser Leu Cys Lys Ala Val
                805                 810                 815     
His His Leu Ala Thr Val Asp Cys Ile Phe Ser Leu Ala Lys Val Ala
            820                 825                 830         
Lys Gln Gly Asp Tyr Cys Arg Pro Thr Val Gln Glu Glu Arg Lys Ile
        835                 840                 845             
Val Ile Lys Asn Gly Arg His Pro Val Ile Asp Val Leu Leu Gly Glu
    850                 855                 860                 
Gln Asp Gln Tyr Val Pro Asn Asn Thr Asp Leu Ser Glu Asp Ser Glu
865                 870                 875                 880 
Arg Val Met Ile Ile Thr Gly Pro Asn Met Gly Gly Lys Ser Ser Tyr
                885                 890                 895     
Ile Lys Gln Val Ala Leu Ile Thr Ile Met Ala Gln Ile Gly Ser Tyr
            900                 905                 910         
Val Pro Ala Glu Glu Ala Thr Ile Gly Ile Val Asp Gly Ile Phe Thr
        915                 920                 925             
Arg Met Gly Ala Ala Asp Asn Ile Tyr Lys Gly Arg Ser Thr Phe Met
    930                 935                 940                 
Glu Glu Leu Thr Asp Thr Ala Glu Ile Ile Arg Lys Ala Thr Ser Gln
945                 950                 955                 960 
Ser Leu Val Ile Leu Asp Glu Leu Gly Arg Gly Thr Ser Thr His Asp
                965                 970                 975     
Gly Ile Ala Ile Ala Tyr Ala Thr Leu Glu Tyr Phe Ile Arg Asp Val
            980                 985                 990         
Lys Ser Leu Thr Leu Phe Val Thr His Tyr Pro Pro Val Cys Glu Leu
        995                 1000                1005            
Glu Lys Asn Tyr Ser His Gln Val Gly Asn Tyr His Met Gly Phe Leu
    1010                1015                1020                
Val Ser Glu Asp Glu Ser Lys Leu Asp Pro Gly Ala Ala Glu Gln Val
1025                1030                1035                1040
Pro Asp Phe Val Thr Phe Leu Tyr Gln Ile Thr Arg Gly Ile Ala Ala
                1045                1050                1055    
Arg Ser Tyr Gly Leu Asn Val Ala Lys Leu Ala Asp Val Pro Gly Glu
            1060                1065                1070        
Ile Leu Lys Lys Ala Ala His Lys Ser Lys Glu Leu Glu Gly Leu Ile
        1075                1080                1085            
Asn Thr Lys Arg Lys Arg Leu Lys Tyr Phe Ala Lys Leu Trp Thr Met
    1090                1095                1100                
His Asn Ala Gln Asp Leu Gln Lys Trp Thr Glu Glu Phe Asn Met Glu
1105                1110                1115                1120
Glu Thr Gln Thr Ser Leu Leu His
                1125            


<210> 453
<211> 577
<212> PRT
<213> Homo sapiens

<400> 453
Met Pro Lys Thr Ile Ser Val Arg Val Thr Thr Met Asp Ala Glu Leu
 1               5                  10                  15      
Glu Phe Ala Ile Gln Pro Asn Thr Thr Gly Lys Gln Leu Phe Asp Gln
            20                  25                  30          
Val Val Lys Thr Ile Gly Leu Arg Glu Val Trp Phe Phe Gly Leu Gln
        35                  40                  45              
Tyr Gln Asp Thr Lys Gly Phe Ser Thr Trp Leu Lys Leu Asn Lys Lys
    50                  55                  60                  
Val Thr Ala Gln Asp Val Arg Lys Glu Ser Pro Leu Leu Phe Lys Phe
65                  70                  75                  80  
Arg Ala Lys Phe Tyr Pro Glu Asp Val Ser Glu Glu Leu Ile Gln Asp
                85                  90                  95      
Ile Thr Gln Arg Leu Phe Phe Leu Gln Val Lys Glu Gly Ile Leu Asn
            100                 105                 110         
Asp Asp Ile Tyr Cys Pro Pro Glu Thr Ala Val Leu Leu Ala Ser Tyr
        115                 120                 125             
Ala Val Gln Ser Lys Tyr Gly Asp Phe Asn Lys Glu Val His Lys Ser
    130                 135                 140                 
Gly Tyr Leu Ala Gly Asp Lys Leu Leu Pro Gln Arg Val Leu Glu Gln
145                 150                 155                 160 
His Lys Leu Asn Lys Asp Gln Trp Glu Glu Arg Ile Gln Val Trp His
                165                 170                 175     
Glu Glu His Arg Gly Met Leu Arg Glu Asp Ala Val Leu Glu Tyr Leu
            180                 185                 190         
Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Val Asn Tyr Phe Ser Ile
        195                 200                 205             
Lys Asn Lys Lys Gly Ser Glu Leu Trp Leu Gly Val Asp Ala Leu Gly
    210                 215                 220                 
Leu Asn Ile Tyr Glu Gln Asn Asp Arg Leu Thr Pro Lys Ile Gly Phe
225                 230                 235                 240 
Pro Trp Ser Glu Ile Arg Asn Ile Ser Phe Asn Asp Lys Lys Phe Val
                245                 250                 255     
Ile Lys Pro Ile Asp Lys Lys Ala Pro Asp Phe Val Phe Tyr Ala Pro
            260                 265                 270         
Arg Leu Arg Ile Asn Lys Arg Ile Leu Ala Leu Cys Met Gly Asn His
        275                 280                 285             
Glu Leu Tyr Met Arg Arg Arg Lys Pro Asp Thr Ile Glu Val Gln Gln
    290                 295                 300                 
Met Lys Ala Gln Ala Arg Glu Glu Lys His Gln Lys Gln Met Glu Arg
305                 310                 315                 320 
Ala Met Leu Glu Asn Glu Lys Lys Lys Arg Glu Met Ala Glu Lys Glu
                325                 330                 335     
Lys Glu Lys Ile Glu Arg Glu Lys Glu Glu Leu Met Glu Arg Leu Lys
            340                 345                 350         
Gln Ile Glu Glu Gln Thr Lys Lys Ala Gln Gln Glu Leu Glu Glu Gln
        355                 360                 365             
Thr Arg Arg Ala Leu Glu Leu Glu Gln Glu Arg Lys Arg Ala Gln Ser
    370                 375                 380                 
Glu Ala Glu Lys Leu Ala Lys Glu Arg Gln Glu Ala Glu Glu Ala Lys
385                 390                 395                 400 
Glu Ala Leu Leu Gln Ala Ser Arg Asp Gln Lys Lys Thr Gln Glu Gln
                405                 410                 415     
Leu Ala Leu Glu Met Ala Glu Leu Thr Ala Arg Ile Ser Gln Leu Glu
            420                 425                 430         
Met Ala Arg Gln Lys Lys Glu Ser Glu Ala Val Glu Trp Gln Gln Lys
        435                 440                 445             
Ala Gln Met Val Gln Glu Asp Leu Glu Lys Thr Arg Ala Glu Leu Lys
    450                 455                 460                 
Thr Ala Met Ser Thr Pro His Val Ala Glu Pro Ala Glu Asn Glu Gln
465                 470                 475                 480 
Asp Glu Gln Asp Glu Asn Gly Ala Glu Ala Ser Ala Asp Leu Arg Ala
                485                 490                 495     
Asp Ala Met Ala Lys Asp Arg Ser Glu Glu Glu Arg Thr Thr Glu Ala
            500                 505                 510         
Glu Lys Asn Glu Arg Val Gln Lys His Leu Lys Ala Leu Thr Ser Glu
        515                 520                 525             
Leu Ala Asn Ala Arg Asp Glu Ser Lys Lys Thr Ala Asn Asp Met Ile
    530                 535                 540                 
His Ala Glu Asn Met Arg Leu Gly Arg Asp Lys Tyr Lys Thr Leu Arg
545                 550                 555                 560 
Gln Ile Arg Gln Gly Asn Thr Lys Gln Arg Ile Asp Glu Phe Glu Ser
                565                 570                 575     
Met
    


<210> 454
<211> 577
<212> PRT
<213> Homo sapiens

<400> 454
Met Pro Lys Thr Ile Ser Val Arg Val Thr Thr Met Asp Ala Glu Leu
 1               5                  10                  15      
Glu Phe Ala Ile Gln Pro Asn Thr Thr Gly Lys Gln Leu Phe Asp Gln
            20                  25                  30          
Val Val Lys Thr Ile Gly Leu Arg Glu Val Trp Phe Phe Gly Leu Gln
        35                  40                  45              
Tyr Gln Asp Thr Lys Gly Phe Ser Thr Trp Leu Lys Leu Asn Lys Lys
    50                  55                  60                  
Val Thr Ala Gln Asp Val Arg Lys Glu Ser Pro Leu Leu Phe Lys Phe
65                  70                  75                  80  
Arg Ala Lys Phe Tyr Pro Glu Asp Val Ser Glu Glu Leu Ile Gln Asp
                85                  90                  95      
Ile Thr Gln Arg Leu Phe Phe Leu Gln Val Lys Glu Gly Ile Leu Asn
            100                 105                 110         
Asp Asp Ile Tyr Cys Pro Pro Glu Thr Ala Val Leu Leu Ala Ser Tyr
        115                 120                 125             
Ala Val Gln Ser Lys Tyr Gly Asp Phe Asn Lys Glu Val His Lys Ser
    130                 135                 140                 
Gly Tyr Leu Ala Gly Asp Lys Leu Leu Pro Gln Arg Val Leu Glu Gln
145                 150                 155                 160 
His Lys Leu Asn Lys Asp Gln Trp Glu Glu Arg Ile Gln Val Trp His
                165                 170                 175     
Glu Glu His Arg Gly Met Leu Arg Glu Asp Ala Val Leu Glu Tyr Leu
            180                 185                 190         
Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Val Asn Tyr Phe Ser Ile
        195                 200                 205             
Lys Asn Lys Lys Gly Ser Glu Leu Trp Leu Gly Val Asp Ala Leu Gly
    210                 215                 220                 
Leu Asn Ile Tyr Glu Gln Asn Asp Arg Leu Thr Pro Lys Ile Gly Phe
225                 230                 235                 240 
Pro Trp Ser Glu Ile Arg Asn Ile Ser Phe Asn Asp Lys Lys Phe Val
                245                 250                 255     
Ile Lys Pro Ile Asp Lys Lys Ala Pro Asp Phe Val Phe Tyr Ala Pro
            260                 265                 270         
Arg Leu Arg Ile Asn Lys Arg Ile Leu Ala Leu Cys Met Gly Asn His
        275                 280                 285             
Glu Leu Tyr Met Arg Arg Arg Lys Pro Asp Thr Ile Glu Val Gln Gln
    290                 295                 300                 
Met Lys Ala Gln Ala Arg Glu Glu Lys His Gln Lys Gln Met Glu Arg
305                 310                 315                 320 
Ala Met Leu Glu Asn Glu Lys Lys Lys Arg Glu Met Ala Glu Lys Glu
                325                 330                 335     
Lys Glu Lys Ile Glu Arg Glu Lys Glu Glu Leu Met Glu Arg Leu Lys
            340                 345                 350         
Gln Ile Glu Glu Gln Thr Lys Lys Ala Gln Gln Glu Leu Glu Glu Gln
        355                 360                 365             
Thr Arg Arg Ala Leu Glu Leu Glu Gln Glu Arg Lys Arg Ala Gln Ser
    370                 375                 380                 
Glu Ala Glu Lys Leu Ala Lys Glu Arg Gln Glu Ala Glu Glu Ala Lys
385                 390                 395                 400 
Glu Ala Leu Leu Gln Ala Ser Arg Asp Gln Lys Lys Thr Gln Glu Gln
                405                 410                 415     
Leu Ala Leu Glu Met Ala Glu Leu Thr Ala Arg Ile Ser Gln Leu Glu
            420                 425                 430         
Met Ala Arg Gln Lys Lys Glu Ser Glu Ala Val Glu Trp Gln Gln Lys
        435                 440                 445             
Ala Gln Met Val Gln Glu Asp Leu Glu Lys Thr Arg Ala Glu Leu Lys
    450                 455                 460                 
Thr Ala Met Ser Thr Pro His Val Ala Glu Pro Ala Glu Asn Glu Gln
465                 470                 475                 480 
Asp Glu Gln Asp Glu Asn Gly Ala Glu Ala Ser Ala Asp Leu Arg Ala
                485                 490                 495     
Asp Ala Met Ala Lys Asp Arg Ser Glu Glu Glu Arg Thr Thr Glu Ala
            500                 505                 510         
Glu Lys Asn Glu Arg Val Gln Lys His Leu Lys Ala Leu Thr Ser Glu
        515                 520                 525             
Leu Ala Asn Ala Arg Asp Glu Ser Lys Lys Thr Ala Asn Asp Met Ile
    530                 535                 540                 
His Ala Glu Asn Met Arg Leu Gly Arg Asp Lys Tyr Lys Thr Leu Arg
545                 550                 555                 560 
Gln Ile Arg Gln Gly Asn Thr Lys Gln Arg Ile Asp Glu Phe Glu Ser
                565                 570                 575     
Met
    


<210> 455
<211> 99
<212> PRT
<213> Homo sapiens

<400> 455
Met Ala Ala Ala Ala Ala Ser Arg Gly Val Gly Ala Lys Leu Gly Leu
 1               5                  10                  15      
Arg Glu Ile Arg Ile His Leu Cys Gln Arg Ser Pro Gly Ser Gln Gly
            20                  25                  30          
Val Arg Asp Phe Ile Glu Lys Arg Tyr Val Glu Leu Lys Lys Ala Asn
        35                  40                  45              
Pro Asp Leu Pro Ile Leu Ile Arg Glu Cys Ser Asp Val Gln Pro Lys
    50                  55                  60                  
Leu Trp Ala Arg Tyr Ala Phe Gly Gln Glu Thr Asn Val Pro Leu Asn
65                  70                  75                  80  
Asn Phe Ser Ala Asp Gln Val Thr Arg Ala Leu Glu Asn Val Leu Ser
                85                  90                  95      
Gly Lys Ala
            


<210> 456
<211> 81
<212> PRT
<213> Homo sapiens

<400> 456
Met Leu Arg Gln Ile Ile Gly Gln Ala Lys Lys His Pro Ser Leu Ile
 1               5                  10                  15      
Pro Leu Phe Val Phe Ile Gly Thr Gly Ala Thr Gly Ala Thr Leu Tyr
            20                  25                  30          
Leu Leu Arg Leu Ala Leu Phe Asn Pro Asp Val Cys Trp Asp Arg Asn
        35                  40                  45              
Asn Pro Glu Pro Trp Asn Lys Leu Gly Pro Asn Asp Gln Tyr Lys Phe
    50                  55                  60                  
Tyr Ser Val Asn Val Asp Tyr Ser Lys Leu Lys Lys Glu Arg Pro Asp
65                  70                  75                  80  
Phe
    


<210> 457
<211> 128
<212> PRT
<213> Homo sapiens

<400> 457
Met Ala Gly Ser Gly Val Arg Gln Ala Thr Ser Thr Ala Ser Thr Phe
 1               5                  10                  15      
Val Lys Pro Ile Phe Ser Arg Asp Met Asn Glu Ala Lys Arg Arg Val
            20                  25                  30          
Arg Glu Leu Tyr Arg Ala Trp Tyr Arg Glu Val Pro Asn Thr Val His
        35                  40                  45              
Gln Phe Gln Leu Asp Ile Thr Val Lys Met Gly Arg Asp Lys Val Arg
    50                  55                  60                  
Glu Met Phe Met Lys Asn Ala His Val Thr Asp Pro Arg Val Val Asp
65                  70                  75                  80  
Leu Leu Val Ile Lys Gly Lys Ile Glu Leu Glu Glu Thr Ile Lys Val
                85                  90                  95      
Trp Lys Gln Arg Thr His Val Met Arg Phe Phe His Glu Thr Glu Ala
            100                 105                 110         
Pro Arg Pro Lys Asp Phe Leu Ser Lys Phe Tyr Val Gly His Asp Pro
        115                 120                 125             


<210> 458
<211> 98
<212> PRT
<213> Homo sapiens

<400> 458
Met Ala His Glu His Gly His Glu His Gly His His Lys Met Glu Leu
 1               5                  10                  15      
Pro Asp Tyr Arg Gln Trp Lys Ile Glu Gly Thr Pro Leu Glu Thr Ile
            20                  25                  30          
Gln Lys Lys Leu Ala Ala Lys Gly Leu Arg Asp Pro Trp Gly Arg Asn
        35                  40                  45              
Glu Ala Trp Arg Tyr Met Gly Gly Phe Ala Lys Ser Val Ser Phe Ser
    50                  55                  60                  
Asp Val Phe Phe Lys Gly Phe Lys Trp Gly Phe Ala Ala Phe Val Val
65                  70                  75                  80  
Ala Val Gly Ala Glu Tyr Tyr Leu Glu Ser Leu Asn Lys Asp Lys Lys
                85                  90                  95      
His His
        


<210> 459
<211> 189
<212> PRT
<213> Homo sapiens

<400> 459
Met Ala Ala Met Ser Leu Leu Arg Arg Val Ser Val Thr Ala Val Ala
 1               5                  10                  15      
Ala Leu Ser Gly Arg Pro Leu Gly Thr Arg Leu Gly Phe Gly Gly Phe
            20                  25                  30          
Leu Thr Arg Gly Phe Pro Lys Ala Ala Ala Pro Val Arg His Ser Gly
        35                  40                  45              
Asp His Gly Lys Arg Leu Phe Val Ile Arg Pro Ser Arg Phe Tyr Asp
    50                  55                  60                  
Arg Arg Phe Leu Lys Leu Leu Arg Phe Tyr Ile Ala Leu Thr Gly Ile
65                  70                  75                  80  
Pro Val Ala Ile Phe Ile Thr Leu Val Asn Val Phe Ile Gly Gln Ala
                85                  90                  95      
Glu Leu Ala Glu Ile Pro Glu Gly Tyr Val Pro Glu His Trp Glu Tyr
            100                 105                 110         
Tyr Lys His Pro Ile Ser Arg Trp Ile Ala Arg Asn Phe Tyr Asp Ser
        115                 120                 125             
Pro Glu Lys Ile Tyr Glu Arg Thr Met Ala Val Leu Gln Ile Glu Ala
    130                 135                 140                 
Glu Lys Ala Glu Leu Arg Val Lys Glu Leu Glu Val Arg Lys Leu Met
145                 150                 155                 160 
His Val Arg Gly Asp Gly Pro Trp Tyr Tyr Tyr Glu Thr Ile Asp Lys
                165                 170                 175     
Glu Leu Ile Asp His Ser Pro Lys Ala Thr Pro Asp Asn
            180                 185                 


<210> 460
<211> 128
<212> PRT
<213> Homo sapiens

<400> 460
Met Thr Gly Tyr Thr Pro Asp Glu Lys Leu Arg Leu Gln Gln Leu Arg
 1               5                  10                  15      
Glu Leu Arg Arg Arg Trp Leu Lys Asp Gln Glu Leu Ser Pro Arg Glu
            20                  25                  30          
Pro Val Leu Pro Pro Gln Lys Met Gly Pro Met Glu Lys Phe Trp Asn
        35                  40                  45              
Lys Phe Leu Glu Asn Lys Ser Pro Trp Arg Lys Met Val His Gly Val
    50                  55                  60                  
Tyr Lys Lys Ser Ile Phe Val Phe Thr His Val Leu Val Pro Val Trp
65                  70                  75                  80  
Ile Ile His Tyr Tyr Met Lys Tyr His Val Ser Glu Lys Pro Tyr Gly
                85                  90                  95      
Ile Val Glu Lys Lys Ser Arg Ile Phe Pro Gly Asp Thr Ile Leu Glu
            100                 105                 110         
Thr Gly Glu Val Ile Pro Pro Met Lys Glu Phe Pro Asp Gln His His
        115                 120                 125             


<210> 461
<211> 76
<212> PRT
<213> Homo sapiens

<400> 461
Met Ala Pro Ser Ala Leu Leu Arg Pro Leu Ser Arg Leu Leu Ala Pro
 1               5                  10                  15      
Ala Arg Leu Pro Ser Gly Pro Ser Val Arg Ser Lys Phe Tyr Val Arg
            20                  25                  30          
Glu Pro Pro Asn Ala Lys Pro Asp Trp Leu Lys Val Gly Phe Thr Leu
        35                  40                  45              
Gly Thr Thr Val Phe Leu Trp Ile Tyr Leu Ile Lys Gln His Asn Glu
    50                  55                  60                  
Asp Ile Leu Glu Tyr Lys Arg Arg Asn Gly Leu Glu
65                  70                  75      


<210> 462
<211> 175
<212> PRT
<213> Homo sapiens

<400> 462
Met Ala Ala Val Ser Met Ser Val Val Leu Arg Gln Thr Leu Trp Arg
 1               5                  10                  15      
Arg Arg Ala Val Ala Val Ala Ala Leu Ser Val Ser Arg Val Pro Thr
            20                  25                  30          
Arg Ser Leu Arg Thr Ser Thr Trp Arg Leu Ala Gln Asp Gln Thr Gln
        35                  40                  45              
Asp Thr Gln Leu Ile Thr Val Asp Glu Lys Leu Asp Ile Thr Thr Leu
    50                  55                  60                  
Thr Gly Val Pro Glu Glu His Ile Lys Thr Arg Lys Val Arg Ile Phe
65                  70                  75                  80  
Val Pro Ala Arg Asn Asn Met Gln Ser Gly Val Asn Asn Thr Lys Lys
                85                  90                  95      
Trp Lys Met Glu Phe Asp Thr Arg Glu Arg Trp Glu Asn Pro Leu Met
            100                 105                 110         
Gly Trp Ala Ser Thr Ala Asp Pro Leu Ser Asn Met Val Leu Thr Phe
        115                 120                 125             
Ser Thr Lys Glu Asp Ala Val Ser Phe Ala Glu Lys Asn Gly Trp Ser
    130                 135                 140                 
Tyr Asp Ile Glu Glu Arg Lys Val Pro Lys Pro Lys Ser Lys Ser Tyr
145                 150                 155                 160 
Gly Ala Asn Phe Ser Trp Asn Lys Arg Thr Arg Val Ser Thr Lys
                165                 170                 175 


<210> 463
<211> 210
<212> PRT
<213> Homo sapiens

<400> 463
Met Arg Cys Leu Thr Thr Pro Met Leu Leu Arg Ala Leu Ala Gln Ala
 1               5                  10                  15      
Ala Arg Ala Gly Pro Pro Gly Gly Arg Ser Leu His Ser Ser Ala Val
            20                  25                  30          
Ala Ala Thr Tyr Lys Tyr Val Asn Met Gln Asp Pro Glu Met Asp Met
        35                  40                  45              
Lys Ser Val Thr Asp Arg Ala Ala Arg Thr Leu Leu Trp Thr Glu Leu
    50                  55                  60                  
Phe Arg Gly Leu Gly Met Thr Leu Ser Tyr Leu Phe Arg Glu Pro Ala
65                  70                  75                  80  
Thr Ile Asn Tyr Pro Phe Glu Lys Gly Pro Leu Ser Pro Arg Phe Arg
                85                  90                  95      
Gly Glu His Ala Leu Arg Arg Tyr Pro Ser Gly Glu Glu Arg Cys Ile
            100                 105                 110         
Ala Cys Lys Leu Cys Glu Ala Ile Cys Pro Ala Gln Ala Ile Thr Ile
        115                 120                 125             
Glu Ala Glu Pro Arg Ala Asp Gly Ser Arg Arg Thr Thr Arg Tyr Asp
    130                 135                 140                 
Ile Asp Met Thr Lys Cys Ile Tyr Cys Gly Phe Cys Gln Glu Ala Cys
145                 150                 155                 160 
Pro Val Asp Ala Ile Val Glu Gly Pro Asn Phe Glu Phe Ser Thr Glu
                165                 170                 175     
Thr His Glu Glu Leu Leu Tyr Asn Lys Glu Lys Leu Leu Asn Asn Gly
            180                 185                 190         
Asp Lys Trp Glu Ala Glu Ile Ala Ala Asn Ile Gln Ala Asp Tyr Leu
        195                 200                 205             
Tyr Arg
    210 


<210> 464
<211> 1461
<212> PRT
<213> Homo sapiens

<400> 464
Met Ala Ala Glu Arg Gly Ala Arg Arg Leu Leu Ser Thr Pro Ser Phe
 1               5                  10                  15      
Trp Leu Tyr Cys Leu Leu Leu Leu Gly Arg Arg Ala Pro Gly Ala Ala
            20                  25                  30          
Ala Ala Arg Ser Gly Ser Ala Pro Gln Ser Pro Gly Ala Ser Ile Arg
        35                  40                  45              
Thr Phe Thr Pro Phe Tyr Phe Leu Val Glu Pro Val Asp Thr Leu Ser
    50                  55                  60                  
Val Arg Gly Ser Ser Val Ile Leu Asn Cys Ser Ala Tyr Ser Glu Pro
65                  70                  75                  80  
Ser Pro Lys Ile Glu Trp Lys Lys Asp Gly Thr Phe Leu Asn Leu Val
                85                  90                  95      
Ser Asp Asp Arg Arg Gln Leu Leu Pro Asp Gly Ser Leu Phe Ile Ser
            100                 105                 110         
Asn Val Val His Ser Lys His Asn Lys Pro Asp Glu Gly Tyr Tyr Gln
        115                 120                 125             
Cys Val Ala Thr Val Glu Ser Leu Gly Thr Ile Ile Ser Arg Thr Ala
    130                 135                 140                 
Lys Leu Ile Val Ala Gly Leu Pro Arg Phe Thr Ser Gln Pro Glu Pro
145                 150                 155                 160 
Ser Ser Val Tyr Ala Gly Asn Gly Ala Ile Leu Asn Cys Glu Val Asn
                165                 170                 175     
Ala Asp Leu Val Pro Phe Val Arg Trp Glu Gln Asn Arg Gln Pro Leu
            180                 185                 190         
Leu Leu Asp Asp Arg Val Ile Lys Leu Pro Ser Gly Met Leu Val Ile
        195                 200                 205             
Ser Asn Ala Thr Glu Gly Asp Gly Gly Leu Tyr Arg Cys Val Val Glu
    210                 215                 220                 
Ser Gly Gly Pro Pro Lys Tyr Ser Asp Glu Val Glu Leu Lys Val Leu
225                 230                 235                 240 
Pro Asp Pro Glu Val Ile Ser Asp Leu Val Phe Leu Lys Gln Pro Ser
                245                 250                 255     
Pro Leu Val Arg Val Ile Gly Gln Asp Val Val Leu Pro Cys Val Ala
            260                 265                 270         
Ser Gly Leu Pro Thr Pro Thr Ile Lys Trp Met Lys Asn Glu Glu Ala
        275                 280                 285             
Leu Asp Thr Glu Ser Ser Glu Arg Leu Val Leu Leu Ala Gly Gly Ser
    290                 295                 300                 
Leu Glu Ile Ser Asp Val Thr Glu Asp Asp Ala Gly Thr Tyr Phe Cys
305                 310                 315                 320 
Ile Ala Asp Asn Gly Asn Glu Thr Ile Glu Ala Gln Ala Glu Leu Thr
                325                 330                 335     
Val Gln Ala Gln Pro Glu Phe Leu Lys Gln Pro Thr Asn Ile Tyr Ala
            340                 345                 350         
His Glu Ser Met Asp Ile Val Phe Glu Cys Glu Val Thr Gly Lys Pro
        355                 360                 365             
Thr Pro Thr Val Lys Trp Val Lys Asn Gly Asp Met Val Ile Pro Ser
    370                 375                 380                 
Asp Tyr Phe Lys Ile Val Lys Glu His Asn Leu Gln Val Leu Gly Leu
385                 390                 395                 400 
Val Lys Ser Asp Glu Gly Phe Tyr Gln Cys Ile Ala Glu Asn Asp Val
                405                 410                 415     
Gly Asn Ala Gln Ala Gly Ala Gln Leu Ile Ile Leu Glu His Ala Pro
            420                 425                 430         
Ala Thr Thr Gly Pro Leu Pro Ser Ala Pro Arg Asp Val Val Ala Ser
        435                 440                 445             
Leu Val Ser Thr Arg Phe Ile Lys Leu Thr Trp Arg Thr Pro Ala Ser
    450                 455                 460                 
Asp Pro His Gly Asp Asn Leu Thr Tyr Ser Val Phe Tyr Thr Lys Glu
465                 470                 475                 480 
Gly Ile Ala Arg Glu Arg Val Glu Asn Thr Ser His Pro Gly Glu Met
                485                 490                 495     
Gln Val Thr Ile Gln Asn Leu Met Pro Ala Thr Val Tyr Ile Phe Arg
            500                 505                 510         
Val Met Ala Gln Asn Lys His Gly Ser Gly Glu Ser Ser Ala Pro Leu
        515                 520                 525             
Arg Val Glu Thr Gln Pro Glu Val Gln Leu Pro Gly Pro Ala Pro Asn
    530                 535                 540                 
Leu Arg Ala Tyr Ala Ala Ser Pro Thr Ser Ile Thr Val Thr Trp Glu
545                 550                 555                 560 
Thr Pro Val Ser Gly Asn Gly Glu Ile Gln Asn Tyr Lys Leu Tyr Tyr
                565                 570                 575     
Met Glu Lys Gly Thr Asp Lys Glu Gln Asp Val Asp Val Ser Ser His
            580                 585                 590         
Ser Tyr Thr Ile Asn Gly Leu Lys Lys Tyr Thr Glu Tyr Ser Phe Arg
        595                 600                 605             
Val Val Ala Tyr Asn Lys His Gly Pro Gly Val Ser Thr Pro Asp Val
    610                 615                 620                 
Ala Val Arg Thr Leu Ser Asp Val Pro Ser Ala Ala Pro Gln Asn Leu
625                 630                 635                 640 
Ser Leu Glu Val Arg Asn Ser Lys Ser Ile Met Ile His Trp Gln Pro
                645                 650                 655     
Pro Ala Pro Ala Thr Gln Asn Gly Gln Ile Thr Gly Tyr Lys Ile Arg
            660                 665                 670         
Tyr Arg Lys Ala Ser Arg Lys Ser Asp Val Thr Glu Thr Leu Val Ser
        675                 680                 685             
Gly Thr Gln Leu Ser Gln Leu Ile Glu Gly Leu Asp Arg Gly Thr Glu
    690                 695                 700                 
Tyr Asn Phe Arg Val Ala Ala Leu Thr Ile Asn Gly Thr Gly Pro Ala
705                 710                 715                 720 
Thr Asp Trp Leu Ser Ala Glu Thr Phe Glu Ser Asp Leu Asp Glu Thr
                725                 730                 735     
Arg Val Pro Glu Val Pro Ser Ser Leu His Val Arg Pro Leu Val Thr
            740                 745                 750         
Ser Ile Val Val Ser Trp Thr Pro Pro Glu Asn Gln Asn Ile Val Val
        755                 760                 765             
Arg Gly Tyr Ala Ile Gly Tyr Gly Ile Gly Ser Pro His Ala Gln Thr
    770                 775                 780                 
Ile Lys Val Asp Tyr Lys Gln Arg Tyr Tyr Thr Ile Glu Asn Leu Asp
785                 790                 795                 800 
Pro Ser Ser His Tyr Val Ile Thr Leu Lys Ala Phe Asn Asn Val Gly
                805                 810                 815     
Glu Gly Ile Pro Leu Tyr Glu Ser Ala Val Thr Arg Pro His Thr Asp
            820                 825                 830         
Thr Ser Glu Val Asp Leu Phe Val Ile Asn Ala Pro Tyr Thr Pro Val
        835                 840                 845             
Pro Asp Pro Thr Pro Met Met Pro Pro Val Gly Val Gln Ala Ser Ile
    850                 855                 860                 
Leu Ser His Asp Thr Ile Arg Ile Thr Trp Ala Asp Asn Ser Leu Pro
865                 870                 875                 880 
Lys His Gln Lys Ile Thr Asp Ser Arg Tyr Tyr Thr Val Arg Trp Lys
                885                 890                 895     
Thr Asn Ile Pro Ala Asn Thr Lys Tyr Lys Asn Ala Asn Ala Thr Thr
            900                 905                 910         
Leu Ser Tyr Leu Val Thr Gly Leu Lys Pro Asn Thr Leu Tyr Glu Phe
        915                 920                 925             
Ser Val Met Val Thr Lys Gly Arg Arg Ser Ser Thr Trp Ser Met Thr
    930                 935                 940                 
Ala His Gly Thr Thr Phe Glu Leu Val Pro Thr Ser Pro Pro Lys Asp
945                 950                 955                 960 
Val Thr Val Val Ser Lys Glu Gly Lys Pro Lys Thr Ile Ile Val Asn
                965                 970                 975     
Trp Gln Pro Pro Ser Glu Ala Asn Gly Lys Ile Thr Gly Tyr Ile Ile
            980                 985                 990         
Tyr Tyr Ser Thr Asp Val Asn Ala Glu Ile His Asp Trp Val Ile Glu
        995                 1000                1005            
Pro Val Val Gly Asn Arg Leu Thr His Gln Ile Gln Glu Leu Thr Leu
    1010                1015                1020                
Asp Thr Pro Tyr Tyr Phe Lys Ile Gln Ala Arg Asn Ser Lys Gly Met
1025                1030                1035                1040
Gly Pro Met Ser Glu Ala Val Gln Phe Arg Thr Pro Lys Ala Asp Ser
                1045                1050                1055    
Ser Asp Lys Met Pro Asn Asp Gln Ala Ser Gly Ser Gly Gly Lys Gly
            1060                1065                1070        
Ser Arg Leu Pro Asp Leu Gly Ser Asp Tyr Lys Pro Pro Met Ser Gly
        1075                1080                1085            
Ser Asn Ser Pro His Gly Ser Pro Thr Ser Pro Leu Asp Ser Asn Met
    1090                1095                1100                
Leu Leu Val Ile Ile Val Ser Val Gly Val Ile Thr Ile Val Val Val
1105                1110                1115                1120
Val Ile Ile Ala Val Phe Cys Thr Arg Arg Thr Thr Ser His Gln Lys
                1125                1130                1135    
Lys Lys Arg Ala Ala Cys Lys Ser Val Asn Gly Ser His Lys Tyr Lys
            1140                1145                1150        
Gly Asn Ser Lys Asp Val Lys Pro Pro Asp Leu Trp Ile His His Glu
        1155                1160                1165            
Arg Leu Glu Leu Lys Pro Ile Asp Lys Ser Pro Asp Pro Asn Pro Ile
    1170                1175                1180                
Met Thr Asp Thr Pro Ile Pro Arg Asn Ser Gln Asp Ile Thr Pro Val
1185                1190                1195                1200
Asp Asn Ser Met Asp Ser Asn Ile His Gln Arg Arg Asn Ser Tyr Arg
                1205                1210                1215    
Gly His Glu Ser Glu Asp Ser Met Ser Thr Leu Ala Gly Arg Arg Gly
            1220                1225                1230        
Met Arg Pro Lys Met Met Met Pro Phe Asp Ser Gln Pro Pro Gln Pro
        1235                1240                1245            
Val Ile Ser Ala His Pro Ile His Ser Leu Asp Asn Pro His His His
    1250                1255                1260                
Phe His Ser Ser Ser Leu Ala Ser Pro Ala Arg Ser His Leu Tyr His
1265                1270                1275                1280
Pro Gly Ser Pro Trp Pro Ile Gly Thr Ser Met Ser Leu Ser Asp Arg
                1285                1290                1295    
Ala Asn Ser Thr Glu Ser Val Arg Asn Thr Pro Ser Thr Asp Thr Met
            1300                1305                1310        
Pro Ala Ser Ser Ser Gln Thr Cys Cys Thr Asp His Gln Asp Pro Glu
        1315                1320                1325            
Gly Ala Thr Ser Ser Ser Tyr Leu Ala Ser Ser Gln Glu Glu Asp Ser
    1330                1335                1340                
Gly Gln Ser Leu Pro Thr Ala His Val Arg Pro Ser His Pro Leu Lys
1345                1350                1355                1360
Ser Phe Ala Val Pro Ala Ile Pro Pro Pro Gly Pro Pro Thr Tyr Asp
                1365                1370                1375    
Pro Ala Leu Pro Ser Thr Pro Leu Leu Ser Gln Gln Ala Leu Asn His
            1380                1385                1390        
His Ile His Ser Val Lys Thr Ala Ser Ile Gly Thr Leu Gly Arg Ser
        1395                1400                1405            
Arg Pro Pro Met Pro Val Val Val Pro Ser Ala Pro Glu Val Gln Glu
    1410                1415                1420                
Thr Thr Arg Met Leu Glu Asp Ser Glu Ser Ser Tyr Glu Pro Asp Glu
1425                1430                1435                1440
Leu Thr Lys Glu Met Ala His Leu Glu Gly Leu Met Lys Asp Leu Asn
                1445                1450                1455    
Ala Ile Thr Thr Ala
            1460    


<210> 465
<211> 284
<212> PRT
<213> Homo sapiens

<400> 465
Met Ala Pro Arg Leu Cys Ser Ile Ser Val Thr Ala Arg Arg Leu Leu
 1               5                  10                  15      
Gly Gly Pro Gly Pro Arg Ala Gly Asp Val Ala Ser Ala Ala Ala Ala
            20                  25                  30          
Arg Phe Tyr Ser Lys Asp Asn Glu Gly Ser Trp Phe Arg Ser Leu Phe
        35                  40                  45              
Val His Lys Val Asp Pro Arg Lys Asp Ala His Ser Thr Leu Leu Ser
    50                  55                  60                  
Lys Lys Glu Thr Ser Asn Leu Tyr Lys Ile Gln Phe His Asn Val Lys
65                  70                  75                  80  
Pro Glu Tyr Leu Asp Ala Tyr Asn Ser Leu Thr Glu Ala Val Leu Pro
                85                  90                  95      
Lys Leu His Leu Asp Glu Asp Tyr Pro Cys Ser Leu Val Gly Asn Trp
            100                 105                 110         
Asn Thr Trp Tyr Gly Glu Gln Asp Gln Ala Val His Leu Trp Arg Phe
        115                 120                 125             
Ser Gly Gly Tyr Pro Ala Leu Met Asp Cys Met Asn Lys Leu Lys Asn
    130                 135                 140                 
Asn Lys Glu Tyr Leu Glu Phe Arg Arg Glu Arg Thr Gln Met Leu Leu
145                 150                 155                 160 
Ser Arg Arg Asn Gln Leu Leu Leu Glu Phe Ser Phe Trp Asn Glu Pro
                165                 170                 175     
Gln Pro Arg Met Gly Pro Asn Ile Tyr Glu Leu Arg Thr Tyr Lys Leu
            180                 185                 190         
Lys Pro Gly Thr Met Ile Glu Trp Gly Asn Asn Trp Ala Arg Ala Ile
        195                 200                 205             
Lys Tyr Arg Gln Glu Asn Gln Glu Ala Val Gly Gly Phe Phe Ser Gln
    210                 215                 220                 
Ile Gly Glu Leu Tyr Val Val His His Leu Trp Ala Tyr Lys Asp Leu
225                 230                 235                 240 
Gln Ser Arg Glu Glu Thr Arg Asn Ala Ala Trp Arg Lys Arg Gly Trp
                245                 250                 255     
Asp Glu Asn Val Tyr Tyr Thr Val Pro Leu Val Arg His Met Glu Ser
            260                 265                 270         
Arg Ile Met Ile Pro Leu Lys Ile Ser Pro Leu Gln
        275                 280                 


<210> 466
<211> 560
<212> PRT
<213> Homo sapiens

<400> 466
Met Glu Cys Leu Tyr Tyr Phe Leu Gly Phe Leu Leu Leu Ala Ala Arg
 1               5                  10                  15      
Leu Pro Leu Asp Ala Ala Lys Arg Phe His Asp Val Leu Gly Asn Glu
            20                  25                  30          
Arg Pro Ser Ala Tyr Met Arg Glu His Asn Gln Leu Asn Gly Trp Ser
        35                  40                  45              
Ser Asp Glu Asn Asp Trp Asn Glu Lys Leu Tyr Pro Val Trp Lys Arg
    50                  55                  60                  
Gly Asp Met Arg Trp Lys Asn Ser Trp Lys Gly Gly Arg Val Gln Ala
65                  70                  75                  80  
Val Leu Thr Ser Asp Ser Pro Ala Leu Val Gly Ser Asn Ile Thr Phe
                85                  90                  95      
Ala Val Asn Leu Ile Phe Pro Arg Cys Gln Lys Glu Asp Ala Asn Gly
            100                 105                 110         
Asn Ile Val Tyr Glu Lys Asn Cys Arg Asn Glu Ala Gly Leu Ser Ala
        115                 120                 125             
Asp Pro Tyr Val Tyr Asn Trp Thr Ala Trp Ser Glu Asp Ser Asp Gly
    130                 135                 140                 
Glu Asn Gly Thr Gly Gln Ser His His Asn Val Phe Pro Asp Gly Lys
145                 150                 155                 160 
Pro Phe Pro His His Pro Gly Trp Arg Arg Trp Asn Phe Ile Tyr Val
                165                 170                 175     
Phe His Thr Leu Gly Gln Tyr Phe Gln Lys Leu Gly Arg Cys Ser Val
            180                 185                 190         
Arg Val Ser Val Asn Thr Ala Asn Val Thr Leu Gly Pro Gln Leu Met
        195                 200                 205             
Glu Val Thr Val Tyr Arg Arg His Gly Arg Ala Tyr Val Pro Ile Ala
    210                 215                 220                 
Gln Val Lys Asp Val Tyr Val Val Thr Asp Gln Ile Pro Val Phe Val
225                 230                 235                 240 
Thr Met Phe Gln Lys Asn Asp Arg Asn Ser Ser Asp Glu Thr Phe Leu
                245                 250                 255     
Lys Asp Leu Pro Ile Met Phe Asp Val Leu Ile His Asp Pro Ser His
            260                 265                 270         
Phe Leu Asn Tyr Ser Thr Ile Asn Tyr Lys Trp Ser Phe Gly Asp Asn
        275                 280                 285             
Thr Gly Leu Phe Val Ser Thr Asn His Thr Val Asn His Thr Tyr Val
    290                 295                 300                 
Leu Asn Gly Thr Phe Ser Leu Asn Leu Thr Val Lys Ala Ala Ala Pro
305                 310                 315                 320 
Gly Pro Cys Pro Pro Pro Pro Pro Pro Pro Arg Pro Ser Lys Pro Thr
                325                 330                 335     
Pro Ser Leu Gly Pro Ala Gly Asp Asn Pro Leu Glu Leu Ser Arg Ile
            340                 345                 350         
Pro Asp Glu Asn Cys Gln Ile Asn Arg Tyr Gly His Phe Gln Ala Thr
        355                 360                 365             
Ile Thr Ile Val Glu Gly Ile Leu Glu Val Asn Ile Ile Gln Met Thr
    370                 375                 380                 
Asp Val Leu Met Pro Val Pro Trp Pro Glu Ser Ser Leu Ile Asp Phe
385                 390                 395                 400 
Val Val Thr Cys Gln Gly Ser Ile Pro Thr Glu Val Cys Thr Ile Ile
                405                 410                 415     
Ser Asp Pro Thr Cys Glu Ile Thr Gln Asn Thr Val Cys Ser Pro Val
            420                 425                 430         
Asp Val Asp Glu Met Cys Leu Leu Thr Val Arg Arg Thr Phe Asn Gly
        435                 440                 445             
Ser Gly Thr Tyr Cys Val Asn Leu Thr Leu Gly Asp Asp Thr Ser Leu
    450                 455                 460                 
Ala Leu Thr Ser Thr Leu Ile Ser Val Pro Asp Arg Asp Pro Ala Ser
465                 470                 475                 480 
Pro Leu Arg Met Ala Asn Ser Ala Leu Ile Ser Val Gly Cys Leu Ala
                485                 490                 495     
Ile Phe Val Thr Val Ile Ser Leu Leu Val Tyr Lys Lys His Lys Glu
            500                 505                 510         
Tyr Asn Pro Ile Glu Asn Ser Pro Gly Asn Val Val Arg Ser Lys Gly
        515                 520                 525             
Leu Ser Val Phe Leu Asn Arg Ala Lys Ala Val Phe Phe Pro Gly Asn
    530                 535                 540                 
Gln Glu Lys Asp Pro Leu Leu Lys Asn Gln Glu Phe Lys Gly Val Ser
545                 550                 555                 560 


<210> 467
<211> 199
<212> PRT
<213> Homo sapiens

<400> 467
Met Ser Ser Gly Asn Ala Lys Ile Gly His Pro Ala Pro Asn Phe Lys
 1               5                  10                  15      
Ala Thr Ala Val Met Pro Asp Gly Gln Phe Lys Asp Ile Ser Leu Ser
            20                  25                  30          
Asp Tyr Lys Gly Lys Tyr Val Val Phe Phe Phe Tyr Pro Leu Asp Phe
        35                  40                  45              
Thr Phe Val Cys Pro Thr Glu Ile Ile Ala Phe Ser Asp Arg Ala Glu
    50                  55                  60                  
Glu Phe Lys Lys Leu Asn Cys Gln Val Ile Gly Ala Ser Val Asp Ser
65                  70                  75                  80  
His Phe Cys His Leu Ala Trp Val Asn Thr Pro Lys Lys Gln Gly Gly
                85                  90                  95      
Leu Gly Pro Met Asn Ile Pro Leu Val Ser Asp Pro Lys Arg Thr Ile
            100                 105                 110         
Ala Gln Asp Tyr Gly Val Leu Lys Ala Asp Glu Gly Ile Ser Phe Arg
        115                 120                 125             
Gly Leu Phe Ile Ile Asp Asp Lys Gly Ile Leu Arg Gln Ile Thr Val
    130                 135                 140                 
Asn Asp Leu Pro Val Gly Arg Ser Val Asp Glu Thr Leu Arg Leu Val
145                 150                 155                 160 
Gln Ala Phe Gln Phe Thr Asp Lys His Gly Glu Val Cys Pro Ala Gly
                165                 170                 175     
Trp Lys Pro Gly Ser Asp Thr Ile Lys Pro Asp Val Gln Lys Ser Lys
            180                 185                 190         
Glu Tyr Phe Ser Lys Gln Lys
        195                 


<210> 468
<211> 187
<212> PRT
<213> Homo sapiens

<400> 468
Met Pro Val Asp Leu Ser Lys Trp Ser Gly Pro Leu Ser Leu Gln Glu
 1               5                  10                  15      
Val Asp Glu Gln Pro Gln His Pro Leu His Val Thr Tyr Ala Gly Ala
            20                  25                  30          
Ala Val Asp Glu Leu Gly Lys Val Leu Thr Pro Thr Gln Val Lys Asn
        35                  40                  45              
Arg Pro Thr Ser Ile Ser Trp Asp Gly Leu Asp Ser Gly Lys Leu Tyr
    50                  55                  60                  
Thr Leu Val Leu Thr Asp Pro Asp Ala Pro Ser Arg Lys Asp Pro Lys
65                  70                  75                  80  
Tyr Arg Glu Trp His His Phe Leu Val Val Asn Met Lys Gly Asn Asp
                85                  90                  95      
Ile Ser Ser Gly Thr Val Leu Ser Asp Tyr Val Gly Ser Gly Pro Pro
            100                 105                 110         
Lys Gly Thr Gly Leu His Arg Tyr Val Trp Leu Val Tyr Glu Gln Asp
        115                 120                 125             
Arg Pro Leu Lys Cys Asp Glu Pro Ile Leu Ser Asn Arg Ser Gly Asp
    130                 135                 140                 
His Arg Gly Lys Phe Lys Val Ala Ser Phe Arg Lys Lys Tyr Glu Leu
145                 150                 155                 160 
Arg Ala Pro Val Ala Gly Thr Cys Tyr Gln Ala Glu Trp Asp Asp Tyr
                165                 170                 175     
Val Pro Lys Leu Tyr Glu Gln Leu Ser Gly Lys
            180                 185         


<210> 469
<211> 390
<212> PRT
<213> Homo sapiens

<400> 469
Met Arg Lys Met Leu Ala Ala Val Ser Arg Val Leu Ser Gly Ala Ser
 1               5                  10                  15      
Gln Lys Pro Ala Ser Arg Val Leu Val Ala Ser Arg Asn Phe Ala Asn
            20                  25                  30          
Asp Ala Thr Phe Glu Ile Lys Lys Cys Asp Leu His Arg Leu Glu Glu
        35                  40                  45              
Gly Pro Pro Val Thr Thr Val Leu Thr Arg Glu Asp Gly Leu Lys Tyr
    50                  55                  60                  
Tyr Arg Met Met Gln Thr Val Arg Arg Met Glu Leu Lys Ala Asp Gln
65                  70                  75                  80  
Leu Tyr Lys Gln Lys Ile Ile Arg Gly Phe Cys His Leu Cys Asp Gly
                85                  90                  95      
Gln Glu Ala Cys Cys Val Gly Leu Glu Ala Gly Ile Asn Pro Thr Asp
            100                 105                 110         
His Leu Ile Thr Ala Tyr Arg Ala His Gly Phe Thr Phe Thr Arg Gly
        115                 120                 125             
Leu Ser Val Arg Glu Ile Leu Ala Glu Leu Thr Gly Arg Lys Gly Gly
    130                 135                 140                 
Cys Ala Lys Gly Lys Gly Gly Ser Met His Met Tyr Ala Lys Asn Phe
145                 150                 155                 160 
Tyr Gly Gly Asn Gly Ile Val Gly Ala Gln Val Pro Leu Gly Ala Gly
                165                 170                 175     
Ile Ala Leu Ala Cys Lys Tyr Asn Gly Lys Asp Glu Val Cys Leu Thr
            180                 185                 190         
Leu Tyr Gly Asp Gly Ala Ala Asn Gln Gly Gln Ile Phe Glu Ala Tyr
        195                 200                 205             
Asn Met Ala Ala Leu Trp Lys Leu Pro Cys Ile Phe Ile Cys Glu Asn
    210                 215                 220                 
Asn Arg Tyr Gly Met Gly Thr Ser Val Glu Arg Ala Ala Ala Ser Thr
225                 230                 235                 240 
Asp Tyr Tyr Lys Arg Gly Asp Phe Ile Pro Gly Leu Arg Val Asp Gly
                245                 250                 255     
Met Asp Ile Leu Cys Val Arg Glu Ala Thr Arg Phe Ala Ala Ala Tyr
            260                 265                 270         
Cys Arg Ser Gly Lys Gly Pro Ile Leu Met Glu Leu Gln Thr Tyr Arg
        275                 280                 285             
Tyr His Gly His Ser Met Ser Asp Pro Gly Val Ser Tyr Arg Thr Arg
    290                 295                 300                 
Glu Glu Ile Gln Glu Val Arg Ser Lys Ser Asp Pro Ile Met Leu Leu
305                 310                 315                 320 
Lys Asp Arg Met Val Asn Ser Asn Leu Ala Ser Val Glu Glu Leu Lys
                325                 330                 335     
Glu Ile Asp Val Glu Val Arg Lys Glu Ile Glu Asp Ala Ala Gln Phe
            340                 345                 350         
Ala Thr Ala Asp Pro Glu Pro Pro Leu Glu Glu Leu Gly Tyr His Ile
        355                 360                 365             
Tyr Ser Ser Asp Pro Pro Phe Glu Val Arg Gly Ala Asn Gln Trp Ile
    370                 375                 380                 
Lys Phe Lys Ser Val Ser
385                 390 


<210> 470
<211> 359
<212> PRT
<213> Homo sapiens

<400> 470
Met Ala Ala Val Ser Gly Leu Val Arg Arg Pro Leu Arg Glu Val Ser
 1               5                  10                  15      
Gly Leu Leu Lys Arg Arg Phe His Trp Thr Ala Pro Ala Ala Leu Gln
            20                  25                  30          
Val Thr Val Arg Asp Ala Ile Asn Gln Gly Met Asp Glu Glu Leu Glu
        35                  40                  45              
Arg Asp Glu Lys Val Phe Leu Leu Gly Glu Glu Val Ala Gln Tyr Asp
    50                  55                  60                  
Gly Ala Tyr Lys Val Ser Arg Gly Leu Trp Lys Lys Tyr Gly Asp Lys
65                  70                  75                  80  
Arg Ile Ile Asp Thr Pro Ile Ser Glu Met Gly Phe Ala Gly Ile Ala
                85                  90                  95      
Val Gly Ala Ala Met Ala Gly Leu Arg Pro Ile Cys Glu Phe Met Thr
            100                 105                 110         
Phe Asn Phe Ser Met Gln Ala Ile Asp Gln Val Ile Asn Ser Ala Ala
        115                 120                 125             
Lys Thr Tyr Tyr Met Ser Gly Gly Leu Gln Pro Val Pro Ile Val Phe
    130                 135                 140                 
Arg Gly Pro Asn Gly Ala Ser Ala Gly Val Ala Ala Gln His Ser Gln
145                 150                 155                 160 
Cys Phe Ala Ala Trp Tyr Gly His Cys Pro Gly Leu Lys Val Val Ser
                165                 170                 175     
Pro Trp Asn Ser Glu Asp Ala Lys Gly Leu Ile Lys Ser Ala Ile Arg
            180                 185                 190         
Asp Asn Asn Pro Val Val Val Leu Glu Asn Glu Leu Met Tyr Gly Val
        195                 200                 205             
Pro Phe Glu Phe Leu Pro Glu Ala Gln Ser Lys Asp Phe Leu Ile Pro
    210                 215                 220                 
Ile Gly Lys Ala Lys Ile Glu Arg Gln Gly Thr His Ile Thr Val Val
225                 230                 235                 240 
Ser His Ser Arg Pro Val Gly His Cys Leu Glu Ala Ala Ala Val Leu
                245                 250                 255     
Ser Lys Glu Gly Val Glu Cys Glu Val Ile Asn Met Arg Thr Ile Arg
            260                 265                 270         
Pro Met Asp Met Glu Thr Ile Glu Ala Ser Val Met Lys Thr Asn His
        275                 280                 285             
Leu Val Thr Val Glu Gly Gly Trp Pro Gln Phe Gly Val Gly Ala Glu
    290                 295                 300                 
Ile Cys Ala Arg Ile Met Glu Gly Pro Ala Phe Asn Phe Leu Asp Ala
305                 310                 315                 320 
Pro Ala Val Arg Val Thr Gly Ala Asp Val Pro Met Pro Tyr Ala Lys
                325                 330                 335     
Ile Leu Glu Asp Asn Ser Ile Pro Gln Val Lys Asp Ile Ile Phe Ala
            340                 345                 350         
Ile Lys Lys Thr Leu Asn Ile
        355                 


<210> 471
<211> 411
<212> PRT
<213> Homo sapiens

<400> 471
Met Lys Ala Ala Arg Phe Val Leu Arg Ser Ala Gly Ser Leu Asn Gly
 1               5                  10                  15      
Ala Gly Leu Val Pro Arg Glu Val Glu His Phe Ser Arg Tyr Ser Pro
            20                  25                  30          
Ser Pro Leu Ser Met Lys Gln Leu Leu Asp Phe Gly Ser Glu Asn Ala
        35                  40                  45              
Cys Glu Arg Thr Ser Phe Ala Phe Leu Arg Gln Glu Leu Pro Val Arg
    50                  55                  60                  
Leu Ala Asn Ile Leu Lys Glu Ile Asp Ile Leu Pro Thr Gln Leu Val
65                  70                  75                  80  
Asn Thr Ser Ser Val Gln Leu Val Lys Ser Trp Tyr Ile Gln Ser Leu
                85                  90                  95      
Met Asp Leu Val Glu Phe His Glu Lys Ser Pro Asp Asp Gln Lys Ala
            100                 105                 110         
Leu Ser Asp Phe Val Asp Thr Leu Ile Lys Val Arg Asn Arg His His
        115                 120                 125             
Asn Val Val Pro Thr Met Ala Gln Gly Ile Ile Glu Tyr Lys Asp Ala
    130                 135                 140                 
Cys Thr Val Asp Pro Val Thr Asn Gln Asn Leu Gln Tyr Phe Leu Asp
145                 150                 155                 160 
Arg Phe Tyr Met Asn Arg Ile Ser Thr Arg Met Leu Met Asn Gln His
                165                 170                 175     
Ile Leu Ile Phe Ser Asp Ser Gln Thr Gly Asn Pro Ser His Ile Gly
            180                 185                 190         
Ser Ile Asp Pro Asn Cys Asp Val Val Ala Val Val Gln Asp Ala Phe
        195                 200                 205             
Glu Cys Ser Arg Met Leu Cys Asp Gln Tyr Tyr Leu Ser Ser Pro Glu
    210                 215                 220                 
Leu Lys Leu Thr Gln Val Asn Gly Lys Phe Pro Asp Gln Pro Ile His
225                 230                 235                 240 
Ile Val Tyr Val Pro Ser His Leu His His Met Leu Phe Glu Leu Phe
                245                 250                 255     
Lys Asn Ala Met Arg Ala Thr Val Glu His Gln Glu Asn Gln Pro Ser
            260                 265                 270         
Leu Thr Pro Ile Glu Val Ile Val Val Leu Gly Lys Glu Asp Leu Thr
        275                 280                 285             
Ile Lys Ile Ser Asp Arg Gly Gly Gly Val Pro Leu Arg Ile Ile Asp
    290                 295                 300                 
Arg Leu Phe Ser Tyr Thr Tyr Ser Thr Ala Pro Thr Pro Val Met Asp
305                 310                 315                 320 
Asn Ser Arg Asn Ala Pro Leu Ala Gly Phe Gly Tyr Gly Leu Pro Ile
                325                 330                 335     
Ser Arg Leu Tyr Ala Lys Tyr Phe Gln Gly Asp Leu Asn Leu Tyr Ser
            340                 345                 350         
Leu Ser Gly Tyr Gly Thr Asp Ala Ile Ile Tyr Leu Lys Ala Leu Ser
        355                 360                 365             
Ser Glu Ser Ile Glu Lys Leu Pro Val Phe Asn Lys Ser Ala Phe Lys
    370                 375                 380                 
His Tyr Gln Met Ser Ser Glu Ala Asp Asp Trp Cys Ile Pro Ser Arg
385                 390                 395                 400 
Glu Pro Lys Asn Leu Ala Lys Glu Val Ala Met
                405                 410     


<210> 472
<211> 247
<212> PRT
<213> Homo sapiens

<400> 472
Met Asp Ala Phe Thr Arg Phe Thr Asn Gln Thr Gln Gly Arg Asp Arg
 1               5                  10                  15      
Leu Phe Arg Ala Thr Gln Tyr Thr Cys Met Leu Leu Arg Tyr Leu Leu
            20                  25                  30          
Glu Pro Lys Ala Gly Lys Glu Lys Val Val Met Lys Leu Lys Lys Leu
        35                  40                  45              
Glu Ser Ser Val Ser Thr Gly Arg Lys Trp Phe Arg Leu Gly Asn Val
    50                  55                  60                  
Val His Ala Ile Gln Ala Thr Glu Gln Ser Ile His Ala Thr Asp Leu
65                  70                  75                  80  
Val Pro Arg Leu Cys Leu Thr Leu Ala Asn Leu Asn Arg Val Ile Tyr
                85                  90                  95      
Phe Ile Cys Asp Thr Ile Leu Trp Val Arg Ser Val Gly Leu Thr Ser
            100                 105                 110         
Gly Ile Asn Lys Glu Lys Trp Arg Thr Arg Ala Ala His His Tyr Tyr
        115                 120                 125             
Tyr Ser Leu Leu Leu Ser Leu Val Arg Asp Leu Tyr Glu Ile Ser Leu
    130                 135                 140                 
Gln Met Lys Arg Val Thr Cys Asp Arg Ala Lys Lys Glu Lys Ser Ala
145                 150                 155                 160 
Ser Gln Asp Pro Leu Trp Phe Ser Val Ala Glu Glu Glu Thr Glu Trp
                165                 170                 175     
Leu Gln Ser Phe Leu Leu Leu Leu Phe Arg Ser Leu Lys Gln His Pro
            180                 185                 190         
Pro Leu Leu Leu Asp Thr Val Lys Asn Leu Cys Asp Ile Leu Asn Pro
        195                 200                 205             
Leu Asp Gln Leu Gly Ile Tyr Lys Ser Asn Pro Gly Ile Ile Gly Leu
    210                 215                 220                 
Gly Gly Leu Val Ser Ser Ile Ala Gly Met Ile Thr Val Ala Tyr Pro
225                 230                 235                 240 
Gln Met Lys Leu Lys Thr Arg
                245         


<210> 473
<211> 272
<212> PRT
<213> Homo sapiens

<400> 473
Met Ala Ala Lys Val Phe Glu Ser Ile Gly Lys Phe Gly Leu Ala Leu
 1               5                  10                  15      
Ala Val Ala Gly Gly Val Val Asn Ser Ala Leu Tyr Asn Val Asp Ala
            20                  25                  30          
Gly His Arg Ala Val Ile Phe Asp Arg Phe Arg Gly Val Gln Asp Ile
        35                  40                  45              
Val Val Gly Glu Gly Thr His Phe Leu Ile Pro Trp Val Gln Lys Pro
    50                  55                  60                  
Ile Ile Phe Asp Cys Arg Ser Arg Pro Arg Asn Val Pro Val Ile Thr
65                  70                  75                  80  
Gly Ser Lys Asp Leu Gln Asn Val Asn Ile Thr Leu Arg Ile Leu Phe
                85                  90                  95      
Arg Pro Val Ala Ser Gln Leu Pro Arg Ile Phe Thr Ser Ile Gly Glu
            100                 105                 110         
Asp Tyr Asp Glu Arg Val Leu Pro Ser Ile Thr Thr Glu Ile Leu Lys
        115                 120                 125             
Ser Val Val Ala Arg Phe Asp Ala Gly Glu Leu Ile Thr Gln Arg Glu
    130                 135                 140                 
Leu Val Ser Arg Gln Val Ser Asp Asp Leu Thr Glu Arg Ala Ala Thr
145                 150                 155                 160 
Phe Gly Leu Ile Leu Asp Asp Val Ser Leu Thr His Leu Thr Phe Gly
                165                 170                 175     
Lys Glu Phe Thr Glu Ala Val Glu Ala Lys Gln Val Ala Gln Gln Glu
            180                 185                 190         
Ala Glu Arg Ala Arg Phe Val Val Glu Lys Ala Glu Gln Gln Lys Lys
        195                 200                 205             
Ala Ala Ile Ile Ser Ala Glu Gly Asp Ser Lys Ala Ala Glu Leu Ile
    210                 215                 220                 
Ala Asn Ser Leu Ala Thr Ala Gly Asp Gly Leu Ile Glu Leu Arg Lys
225                 230                 235                 240 
Leu Glu Ala Ala Glu Asp Ile Ala Tyr Gln Leu Ser Arg Ser Arg Asn
                245                 250                 255     
Ile Thr Tyr Leu Pro Ala Gly Gln Ser Val Leu Leu Gln Leu Pro Gln
            260                 265                 270         


<210> 474
<211> 361
<212> PRT
<213> Homo sapiens

<400> 474
Met Phe Ser Ser Val Ala His Leu Ala Arg Ala Asn Pro Phe Asn Thr
 1               5                  10                  15      
Pro His Leu Gln Leu Val His Asp Gly Leu Gly Asp Leu Arg Ser Ser
            20                  25                  30          
Ser Pro Gly Pro Thr Gly Gln Pro Arg Arg Pro Arg Asn Leu Ala Ala
        35                  40                  45              
Ala Ala Val Glu Glu Tyr Ser Cys Glu Phe Gly Ser Ala Lys Tyr Tyr
    50                  55                  60                  
Ala Leu Cys Gly Phe Gly Gly Val Leu Ser Cys Gly Leu Thr His Thr
65                  70                  75                  80  
Ala Val Val Pro Leu Asp Leu Val Lys Cys Arg Met Gln Val Asp Pro
                85                  90                  95      
Gln Lys Tyr Lys Gly Ile Phe Asn Gly Phe Ser Val Thr Leu Lys Glu
            100                 105                 110         
Asp Gly Val Arg Gly Leu Ala Lys Gly Trp Ala Pro Thr Phe Leu Gly
        115                 120                 125             
Tyr Ser Met Gln Gly Leu Cys Lys Phe Gly Phe Tyr Glu Val Phe Lys
    130                 135                 140                 
Val Leu Tyr Ser Asn Met Leu Gly Glu Glu Asn Thr Tyr Leu Trp Arg
145                 150                 155                 160 
Thr Ser Leu Tyr Leu Ala Ala Ser Ala Ser Ala Glu Phe Phe Ala Asp
                165                 170                 175     
Ile Ala Leu Ala Pro Met Glu Ala Ala Lys Val Arg Ile Gln Thr Gln
            180                 185                 190         
Pro Gly Tyr Ala Asn Thr Leu Arg Asp Ala Ala Pro Lys Met Tyr Lys
        195                 200                 205             
Glu Glu Gly Leu Lys Ala Phe Tyr Lys Gly Val Ala Pro Leu Trp Met
    210                 215                 220                 
Arg Gln Ile Pro Tyr Thr Met Met Lys Phe Ala Cys Phe Glu Arg Thr
225                 230                 235                 240 
Val Glu Ala Leu Tyr Lys Phe Val Val Pro Lys Pro Arg Ser Glu Cys
                245                 250                 255     
Ser Lys Pro Glu Gln Leu Val Val Thr Phe Val Ala Gly Tyr Ile Ala
            260                 265                 270         
Gly Val Phe Cys Ala Ile Val Ser His Pro Ala Asp Ser Val Val Ser
        275                 280                 285             
Val Leu Asn Lys Glu Lys Gly Ser Ser Ala Ser Leu Val Leu Lys Arg
    290                 295                 300                 
Leu Gly Phe Lys Gly Val Trp Lys Gly Leu Phe Ala Arg Ile Ile Met
305                 310                 315                 320 
Ile Gly Thr Leu Thr Ala Leu Gln Trp Phe Ile Tyr Asp Ser Val Lys
                325                 330                 335     
Val Tyr Phe Arg Leu Pro Arg Pro Pro Pro Pro Glu Met Pro Glu Ser
            340                 345                 350         
Leu Lys Lys Lys Leu Gly Leu Thr Gln
        355                 360     


<210> 475
<211> 361
<212> PRT
<213> Homo sapiens

<400> 475
Met Phe Ser Ser Val Ala His Leu Ala Arg Ala Asn Pro Phe Asn Thr
 1               5                  10                  15      
Pro His Leu Gln Leu Val His Asp Gly Leu Gly Asp Leu Arg Ser Ser
            20                  25                  30          
Ser Pro Gly Pro Thr Gly Gln Pro Arg Arg Pro Arg Asn Leu Ala Ala
        35                  40                  45              
Ala Ala Val Glu Glu Tyr Ser Cys Glu Phe Gly Ser Ala Lys Tyr Tyr
    50                  55                  60                  
Ala Leu Cys Gly Phe Gly Gly Val Leu Ser Cys Gly Leu Thr His Thr
65                  70                  75                  80  
Ala Val Val Pro Leu Asp Leu Val Lys Cys Arg Met Gln Val Asp Pro
                85                  90                  95      
Gln Lys Tyr Lys Gly Ile Phe Asn Gly Phe Ser Val Thr Leu Lys Glu
            100                 105                 110         
Asp Gly Val Arg Gly Leu Ala Lys Gly Trp Ala Pro Thr Phe Leu Gly
        115                 120                 125             
Tyr Ser Met Gln Gly Leu Cys Lys Phe Gly Phe Tyr Glu Val Phe Lys
    130                 135                 140                 
Val Leu Tyr Ser Asn Met Leu Gly Glu Glu Asn Thr Tyr Leu Trp Arg
145                 150                 155                 160 
Thr Ser Leu Tyr Leu Ala Ala Ser Ala Ser Ala Glu Phe Phe Ala Asp
                165                 170                 175     
Ile Ala Leu Ala Pro Met Glu Ala Ala Lys Val Arg Ile Gln Thr Gln
            180                 185                 190         
Pro Gly Tyr Ala Asn Thr Leu Arg Asp Ala Ala Pro Lys Met Tyr Lys
        195                 200                 205             
Glu Glu Gly Leu Lys Ala Phe Tyr Lys Gly Val Ala Pro Leu Trp Met
    210                 215                 220                 
Arg Gln Ile Pro Tyr Thr Met Met Lys Phe Ala Cys Phe Glu Arg Thr
225                 230                 235                 240 
Val Glu Ala Leu Tyr Lys Phe Val Val Pro Lys Pro Arg Ser Glu Cys
                245                 250                 255     
Ser Lys Pro Glu Gln Leu Val Val Thr Phe Val Ala Gly Tyr Ile Ala
            260                 265                 270         
Gly Val Phe Cys Ala Ile Val Ser His Pro Ala Asp Ser Val Val Ser
        275                 280                 285             
Val Leu Asn Lys Glu Lys Gly Ser Ser Ala Ser Leu Val Leu Lys Arg
    290                 295                 300                 
Leu Gly Phe Lys Gly Val Trp Lys Gly Leu Phe Ala Arg Ile Ile Met
305                 310                 315                 320 
Ile Gly Thr Leu Thr Ala Leu Gln Trp Phe Ile Tyr Asp Ser Val Lys
                325                 330                 335     
Val Tyr Phe Arg Leu Pro Arg Pro Pro Pro Pro Glu Met Pro Glu Ser
            340                 345                 350         
Leu Lys Lys Lys Leu Gly Leu Thr Gln
        355                 360     


<210> 476
<211> 887
<212> PRT
<213> Homo sapiens

<400> 476
Met Gly Glu Ala Glu Lys Phe His Tyr Ile Tyr Ser Cys Asp Leu Asp
 1               5                  10                  15      
Ile Asn Val Gln Leu Lys Ile Gly Ser Leu Glu Gly Lys Arg Glu Gln
            20                  25                  30          
Lys Ser Tyr Asn Ala Val Leu Glu Asp Pro Met Leu Lys Phe Ser Gly
        35                  40                  45              
Leu Tyr Gln Glu Thr Cys Ser Asp Leu Tyr Val Thr Cys Gln Val Phe
    50                  55                  60                  
Ala Glu Gly Lys Pro Ser Ala Leu Pro Val Arg Thr Ser Tyr Lys Ala
65                  70                  75                  80  
Phe Ser Thr Arg Trp Asn Trp Asn Glu Trp Leu Lys Leu Pro Val Lys
                85                  90                  95      
Tyr Pro Asp Leu Pro Arg Asn Ala Gln Val Ala Leu Thr Ile Trp Asp
            100                 105                 110         
Val Tyr Gly Pro Gly Lys Ala Val Pro Val Gly Gly Thr Thr Val Ser
        115                 120                 125             
Leu Phe Gly Lys Tyr Gly Met Ser Arg Gln Gly Met His Asp Leu Lys
    130                 135                 140                 
Val Trp Pro Asn Val Glu Ala Asp Gly Ser Glu Pro Thr Asn Thr Pro
145                 150                 155                 160 
Gly Arg Thr Ser Ser Thr Leu Ser Glu Asp Gln Met Ser Arg Leu Ala
                165                 170                 175     
Lys Leu Thr Lys Ala His Arg Gln Gly His Met Val Lys Val Asp Trp
            180                 185                 190         
Leu Asp Arg Leu Thr Phe Arg Glu Ile Glu Met Ile Asn Glu Ser Val
        195                 200                 205             
Lys Arg Ser Ser Asn Phe Met Tyr Leu Met Gly Gly Phe Arg Cys Val
    210                 215                 220                 
Lys Cys Asp Asp Lys Glu Tyr Gly Ile Val Tyr Tyr Glu Lys Asp Gly
225                 230                 235                 240 
Asp Glu Ser Ser Pro Ile Leu Thr Ser Phe Glu Leu Val Lys Val Pro
                245                 250                 255     
Asp Pro Gln Met Ser Leu Glu Asn Leu Val Glu Ser Lys His His Asn
            260                 265                 270         
Leu Pro Arg Ser Leu Arg Ser Gly Pro Ser Asp His Asp Leu Lys Pro
        275                 280                 285             
Tyr Pro Ser Pro Arg Asp Gln Leu Lys Asn Ile Val Ser Tyr Pro Pro
    290                 295                 300                 
Ser Lys Pro Pro Thr Tyr Glu Glu Gln Asp Leu Val Trp Glu Phe Arg
305                 310                 315                 320 
Tyr Tyr Leu Thr Asn Gln Asp Lys Ala Leu Thr Lys Ile Leu Thr Ser
                325                 330                 335     
Val Ile Trp Asp Leu Pro Gln Gly Ala Lys Gln Ala Leu Ala Leu Leu
            340                 345                 350         
Gly Lys Trp Asn Pro Met Asp Val Glu Asp Ser Leu Glu Leu Ile Ser
        355                 360                 365             
Ser His Tyr Thr Asn Pro Thr Val Arg Arg Tyr Ala Val Ala Arg Leu
    370                 375                 380                 
Arg Gln Ala Asp Asp Glu Asp Leu Leu Met Tyr Leu Ser Gln Leu Val
385                 390                 395                 400 
Gln Ala Leu Lys Tyr Glu Asn Phe Asp Asp Ile Lys Asn Gly Leu Glu
                405                 410                 415     
Pro Thr Lys Lys Asp Ser Gln Ser Ser Val Ser Gly Asn Val Ser Asn
            420                 425                 430         
Ser Gly Ile Asn Ser Ala Glu Ile Asp Ser Ser Gln Ile Ile Thr Ser
        435                 440                 445             
Pro Leu Pro Ser Val Ser Ser Pro Pro Pro Ala Ser Lys Thr Lys Glu
    450                 455                 460                 
Val Pro Asp Gly Glu Asn Leu Glu Gln Asp Leu Cys Thr Phe Leu Ile
465                 470                 475                 480 
Ser Arg Ala Ser Lys Asn Ser Thr Leu Ala Asn Tyr Leu Tyr Trp Tyr
                485                 490                 495     
Val Ile Val Glu Cys Glu Asp Gln Asp Thr Gln Gln Arg Asp Pro Lys
            500                 505                 510         
Thr His Glu Met Tyr Leu Asn Val Met Arg Arg Phe Ser Gln Ala Leu
        515                 520                 525             
Leu Lys Gly Asp Lys Ser Val Arg Val Met Arg Ser Leu Leu Ala Ala
    530                 535                 540                 
Gln Gln Thr Phe Val Asp Arg Leu Val His Leu Met Lys Ala Val Gln
545                 550                 555                 560 
Arg Glu Ser Gly Asn Arg Lys Lys Lys Asn Glu Arg Leu Gln Ala Leu
                565                 570                 575     
Leu Gly Asp Asn Glu Lys Met Asn Leu Ser Asp Val Glu Leu Ile Pro
            580                 585                 590         
Leu Pro Leu Glu Pro Gln Val Lys Ile Arg Gly Ile Ile Pro Glu Thr
        595                 600                 605             
Ala Thr Leu Phe Lys Ser Ala Leu Met Pro Ala Gln Leu Phe Phe Lys
    610                 615                 620                 
Thr Glu Asp Gly Gly Lys Tyr Pro Val Ile Phe Lys His Gly Asp Asp
625                 630                 635                 640 
Leu Arg Gln Asp Gln Leu Ile Leu Gln Ile Ile Ser Leu Met Asp Lys
                645                 650                 655     
Leu Leu Arg Lys Glu Asn Leu Asp Leu Lys Leu Thr Pro Tyr Lys Val
            660                 665                 670         
Leu Ala Thr Ser Thr Lys His Gly Phe Met Gln Phe Ile Gln Ser Val
        675                 680                 685             
Pro Val Ala Glu Val Leu Asp Thr Glu Gly Ser Ile Gln Asn Phe Phe
    690                 695                 700                 
Arg Lys Tyr Ala Pro Ser Glu Asn Gly Pro Asn Gly Ile Ser Ala Glu
705                 710                 715                 720 
Val Met Asp Thr Tyr Val Lys Ser Cys Ala Gly Tyr Cys Val Ile Thr
                725                 730                 735     
Tyr Ile Leu Gly Val Gly Asp Arg His Leu Asp Asn Leu Val Leu Thr
            740                 745                 750         
Lys Thr Gly Lys Leu Phe His Ile Asp Phe Gly Tyr Ile Leu Gly Arg
        755                 760                 765             
Asp Pro Lys Pro Leu Pro Pro Pro Met Lys Leu Asn Lys Glu Met Val
    770                 775                 780                 
Glu Gly Met Gly Gly Thr Gln Ser Glu Gln Tyr Gln Glu Phe Arg Lys
785                 790                 795                 800 
Gln Cys Tyr Thr Ala Phe Leu His Leu Arg Arg Tyr Ser Asn Leu Ile
                805                 810                 815     
Leu Asn Leu Phe Ser Leu Met Val Asp Pro Asn Ile Pro Asp Ile Ala
            820                 825                 830         
Leu Glu Pro Asp Lys Thr Val Lys Lys Val Gln Asp Lys Phe Arg Leu
        835                 840                 845             
Asp Leu Ser Asp Glu Glu Ala Val His Tyr Met Gln Ser Leu Ile Asp
    850                 855                 860                 
Glu Ser Val His Ala Leu Phe Ala Ala Val Val Glu Gln Ile His Lys
865                 870                 875                 880 
Phe Ala Gln Tyr Trp Arg Lys
                885         


<210> 477
<211> 1290
<212> PRT
<213> Homo sapiens

<400> 477
Met Ala Gly Ala Ala Ser Pro Cys Ala Asn Gly Cys Gly Pro Gly Ala
 1               5                  10                  15      
Pro Ser Asp Ala Glu Val Leu His Leu Cys Arg Ser Leu Glu Val Gly
            20                  25                  30          
Thr Val Met Thr Leu Phe Tyr Ser Lys Lys Ser Gln Arg Pro Glu Arg
        35                  40                  45              
Lys Thr Phe Gln Val Lys Leu Glu Thr Arg Gln Ile Thr Trp Ser Arg
    50                  55                  60                  
Gly Ala Asp Lys Ile Glu Gly Ala Ile Asp Ile Arg Glu Ile Lys Glu
65                  70                  75                  80  
Ile Arg Pro Gly Lys Thr Ser Arg Asp Phe Asp Arg Tyr Gln Glu Asp
                85                  90                  95      
Pro Ala Phe Arg Pro Asp Gln Ser His Cys Phe Val Ile Leu Tyr Gly
            100                 105                 110         
Met Glu Phe Arg Leu Lys Thr Leu Ser Leu Gln Ala Thr Ser Glu Asp
        115                 120                 125             
Glu Val Asn Met Trp Ile Lys Gly Leu Thr Trp Leu Met Glu Asp Thr
    130                 135                 140                 
Leu Gln Ala Pro Thr Pro Leu Gln Ile Glu Arg Trp Leu Arg Lys Gln
145                 150                 155                 160 
Phe Tyr Ser Val Asp Arg Asn Arg Glu Asp Arg Ile Ser Ala Lys Asp
                165                 170                 175     
Leu Lys Asn Met Leu Ser Gln Val Asn Tyr Arg Val Pro Asn Met Arg
            180                 185                 190         
Phe Leu Arg Glu Arg Leu Thr Asp Leu Glu Gln Arg Ser Gly Asp Ile
        195                 200                 205             
Thr Tyr Gly Gln Phe Ala Gln Leu Tyr Arg Ser Leu Met Tyr Ser Ala
    210                 215                 220                 
Gln Lys Thr Met Asp Leu Pro Phe Leu Glu Ala Ser Thr Leu Arg Ala
225                 230                 235                 240 
Gly Glu Arg Pro Glu Leu Cys Arg Val Ser Leu Pro Glu Phe Gln Gln
                245                 250                 255     
Phe Leu Leu Asp Tyr Gln Gly Glu Leu Trp Ala Val Asp Arg Leu Gln
            260                 265                 270         
Val Gln Glu Phe Met Leu Ser Phe Leu Arg Asp Pro Leu Arg Glu Ile
        275                 280                 285             
Glu Glu Pro Tyr Phe Phe Leu Asp Glu Phe Val Thr Phe Leu Phe Ser
    290                 295                 300                 
Lys Glu Asn Ser Val Trp Asn Ser Gln Leu Asp Ala Val Cys Pro Asp
305                 310                 315                 320 
Thr Met Asn Asn Pro Leu Ser His Tyr Trp Ile Ser Ser Ser His Asn
                325                 330                 335     
Thr Tyr Leu Thr Gly Asp Gln Phe Ser Ser Glu Ser Ser Leu Glu Ala
            340                 345                 350         
Tyr Ala Arg Cys Leu Arg Met Gly Cys Arg Cys Ile Glu Leu Asp Cys
        355                 360                 365             
Trp Asp Gly Pro Asp Gly Met Pro Val Ile Tyr His Gly His Thr Leu
    370                 375                 380                 
Thr Thr Lys Ile Lys Phe Ser Asp Val Leu His Thr Ile Lys Glu His
385                 390                 395                 400 
Ala Phe Val Ala Ser Glu Tyr Pro Val Ile Leu Ser Ile Glu Asp His
                405                 410                 415     
Cys Ser Ile Ala Gln Gln Arg Asn Met Ala Gln Tyr Phe Lys Lys Val
            420                 425                 430         
Leu Gly Asp Thr Leu Leu Thr Lys Pro Val Glu Ile Ser Ala Asp Gly
        435                 440                 445             
Leu Pro Ser Pro Asn Gln Leu Lys Arg Lys Ile Leu Ile Lys His Lys
    450                 455                 460                 
Lys Leu Ala Glu Gly Ser Ala Tyr Glu Glu Val Pro Thr Ser Met Met
465                 470                 475                 480 
Tyr Ser Glu Asn Asp Ile Ser Asn Ser Ile Lys Asn Gly Ile Leu Tyr
                485                 490                 495     
Leu Glu Asp Pro Val Asn His Glu Trp Tyr Pro His Tyr Phe Val Leu
            500                 505                 510         
Thr Ser Ser Lys Ile Tyr Tyr Ser Glu Glu Thr Ser Ser Asp Gln Gly
        515                 520                 525             
Asn Glu Asp Glu Glu Glu Pro Lys Glu Val Ser Ser Ser Thr Glu Leu
    530                 535                 540                 
His Ser Asn Glu Lys Trp Phe His Gly Lys Leu Gly Ala Gly Arg Asp
545                 550                 555                 560 
Gly Arg His Ile Ala Glu Arg Leu Leu Thr Glu Tyr Cys Ile Glu Thr
                565                 570                 575     
Gly Ala Pro Asp Gly Ser Phe Leu Val Arg Glu Ser Glu Thr Phe Val
            580                 585                 590         
Gly Asp Tyr Thr Leu Ser Phe Trp Arg Asn Gly Lys Val Gln His Cys
        595                 600                 605             
Arg Ile His Ser Arg Gln Asp Ala Gly Thr Pro Lys Phe Phe Leu Thr
    610                 615                 620                 
Asp Asn Leu Val Phe Asp Ser Leu Tyr Asp Leu Ile Thr His Tyr Gln
625                 630                 635                 640 
Gln Val Pro Leu Arg Cys Asn Glu Phe Glu Met Arg Leu Ser Glu Pro
                645                 650                 655     
Val Pro Gln Thr Asn Ala His Glu Ser Lys Glu Trp Tyr His Ala Ser
            660                 665                 670         
Leu Thr Arg Ala Gln Ala Glu His Met Leu Met Arg Val Pro Arg Asp
        675                 680                 685             
Gly Ala Phe Leu Val Arg Lys Arg Asn Glu Pro Asn Ser Tyr Ala Ile
    690                 695                 700                 
Ser Phe Arg Ala Glu Gly Lys Ile Lys His Cys Arg Val Gln Gln Glu
705                 710                 715                 720 
Gly Gln Thr Val Met Leu Gly Asn Ser Glu Phe Asp Ser Leu Val Asp
                725                 730                 735     
Leu Ile Ser Tyr Tyr Glu Lys His Pro Leu Tyr Arg Lys Met Lys Leu
            740                 745                 750         
Arg Tyr Pro Ile Asn Glu Glu Ala Leu Glu Lys Ile Gly Thr Ala Glu
        755                 760                 765             
Pro Asp Tyr Gly Ala Leu Tyr Glu Gly Arg Asn Pro Gly Phe Tyr Val
    770                 775                 780                 
Glu Ala Asn Pro Met Pro Thr Phe Lys Cys Ala Val Lys Ala Leu Phe
785                 790                 795                 800 
Asp Tyr Lys Ala Gln Arg Glu Asp Glu Leu Thr Phe Ile Lys Ser Ala
                805                 810                 815     
Ile Ile Gln Asn Val Glu Lys Gln Glu Gly Gly Trp Trp Arg Gly Asp
            820                 825                 830         
Tyr Gly Gly Lys Lys Gln Leu Trp Phe Pro Ser Asn Tyr Val Glu Glu
        835                 840                 845             
Met Val Asn Pro Val Ala Leu Glu Pro Glu Arg Glu His Leu Asp Glu
    850                 855                 860                 
Asn Ser Pro Leu Gly Asp Leu Leu Arg Gly Val Leu Asp Val Pro Ala
865                 870                 875                 880 
Cys Gln Ile Ala Ile Arg Pro Glu Gly Lys Asn Asn Arg Leu Phe Val
                885                 890                 895     
Phe Ser Ile Ser Met Ala Ser Val Ala His Trp Ser Leu Asp Val Ala
            900                 905                 910         
Ala Asp Ser Gln Glu Glu Leu Gln Asp Trp Val Lys Lys Ile Arg Glu
        915                 920                 925             
Val Ala Gln Thr Ala Asp Ala Arg Leu Thr Glu Gly Lys Ile Met Glu
    930                 935                 940                 
Arg Arg Lys Lys Ile Ala Leu Glu Leu Ser Glu Leu Val Val Tyr Cys
945                 950                 955                 960 
Arg Pro Val Pro Phe Asp Glu Glu Lys Ile Gly Thr Glu Arg Ala Cys
                965                 970                 975     
Tyr Arg Asp Met Ser Ser Phe Pro Glu Thr Lys Ala Glu Lys Tyr Val
            980                 985                 990         
Asn Lys Ala Lys Gly Lys Lys Phe Leu Gln Tyr Asn Arg Leu Gln Leu
        995                 1000                1005            
Ser Arg Ile Tyr Pro Lys Gly Gln Arg Leu Asp Ser Ser Asn Tyr Asp
    1010                1015                1020                
Pro Leu Pro Met Trp Ile Cys Gly Ser Gln Leu Val Ala Leu Asn Phe
1025                1030                1035                1040
Gln Thr Pro Asp Lys Pro Met Gln Met Asn Gln Ala Leu Phe Met Thr
                1045                1050                1055    
Gly Arg His Cys Gly Tyr Val Leu Gln Pro Ser Thr Met Arg Asp Glu
            1060                1065                1070        
Ala Phe Asp Pro Phe Asp Lys Ser Ser Leu Arg Gly Leu Glu Pro Cys
        1075                1080                1085            
Ala Ile Ser Ile Glu Val Leu Gly Ala Arg His Leu Pro Lys Asn Gly
    1090                1095                1100                
Arg Gly Ile Val Cys Pro Phe Val Glu Ile Glu Val Ala Gly Ala Glu
1105                1110                1115                1120
Tyr Asp Ser Thr Lys Gln Lys Thr Glu Phe Val Val Asp Asn Gly Leu
                1125                1130                1135    
Asn Pro Val Trp Pro Ala Lys Pro Phe His Phe Gln Ile Ser Asn Pro
            1140                1145                1150        
Glu Phe Ala Phe Leu Arg Phe Val Val Tyr Glu Glu Asp Met Phe Ser
        1155                1160                1165            
Asp Gln Asn Phe Leu Ala Gln Ala Thr Phe Pro Val Lys Gly Leu Lys
    1170                1175                1180                
Thr Gly Tyr Arg Ala Val Pro Leu Lys Asn Asn Tyr Ser Glu Asp Leu
1185                1190                1195                1200
Glu Leu Ala Ser Leu Leu Ile Lys Ile Asp Ile Phe Pro Ala Lys Glu
                1205                1210                1215    
Asn Gly Asp Leu Ser Pro Phe Ser Gly Thr Ser Leu Arg Glu Arg Gly
            1220                1225                1230        
Ser Asp Ala Ser Gly Gln Leu Phe His Gly Arg Ala Arg Glu Gly Ser
        1235                1240                1245            
Phe Glu Ser Arg Tyr Gln Gln Pro Phe Glu Asp Phe Arg Ile Ser Gln
    1250                1255                1260                
Glu His Leu Ala Asp His Phe Asp Ser Arg Glu Arg Arg Ala Pro Arg
1265                1270                1275                1280
Arg Thr Arg Val Asn Gly Asp Asn Arg Leu
                1285                1290


<210> 478
<211> 52
<212> PRT
<213> Homo sapiens

<400> 478
Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Ser
 1               5                  10                  15      
Thr Ile Glu Met Pro Gln Gln Ala Arg Gln Lys Leu Gln Asn Leu Phe
            20                  25                  30          
Ile Asn Phe Cys Leu Ile Leu Ile Cys Leu Leu Leu Ile Cys Ile Ile
        35                  40                  45              
Val Met Leu Leu
    50          


<210> 479
<211> 152
<212> PRT
<213> Homo sapiens

<400> 479
Met Ala Asp Ser Glu Arg Leu Ser Ala Pro Gly Cys Trp Ala Ala Cys
 1               5                  10                  15      
Thr Asn Phe Ser Arg Thr Arg Lys Gly Ile Leu Leu Phe Ala Glu Ile
            20                  25                  30          
Ile Leu Cys Leu Val Ile Leu Ile Cys Phe Ser Ala Ser Thr Pro Gly
        35                  40                  45              
Tyr Ser Ser Leu Ser Val Ile Glu Met Ile Leu Ala Ala Ile Phe Phe
    50                  55                  60                  
Val Val Tyr Met Cys Asp Leu His Thr Lys Ile Pro Phe Ile Asn Trp
65                  70                  75                  80  
Pro Trp Ser Asp Phe Phe Arg Thr Leu Ile Ala Ala Ile Leu Tyr Leu
                85                  90                  95      
Ile Thr Ser Ile Val Val Leu Val Glu Arg Gly Asn His Ser Lys Ile
            100                 105                 110         
Val Ala Gly Val Leu Gly Leu Ile Ala Thr Cys Leu Phe Gly Tyr Asp
        115                 120                 125             
Ala Tyr Val Thr Phe Pro Val Arg Gln Pro Arg His Thr Ala Ala Pro
    130                 135                 140                 
Thr Asp Pro Ala Asp Gly Pro Val
145                 150         


<210> 480
<211> 132
<212> PRT
<213> Homo sapiens

<400> 480
Met Ser Asn Lys Phe Leu Gly Thr Trp Lys Leu Val Ser Ser Glu Asn
 1               5                  10                  15      
Phe Asp Asp Tyr Met Lys Ala Leu Gly Val Gly Leu Ala Thr Arg Lys
            20                  25                  30          
Leu Gly Asn Leu Ala Lys Pro Thr Val Ile Ile Ser Lys Lys Gly Asp
        35                  40                  45              
Ile Ile Thr Ile Arg Thr Glu Ser Thr Phe Lys Asn Thr Glu Ile Ser
    50                  55                  60                  
Phe Lys Leu Gly Gln Glu Phe Glu Glu Thr Thr Ala Asp Asn Arg Lys
65                  70                  75                  80  
Thr Lys Ser Ile Val Thr Leu Gln Arg Gly Ser Leu Asn Gln Val Gln
                85                  90                  95      
Arg Trp Asp Gly Lys Glu Thr Thr Ile Lys Arg Lys Leu Val Asn Gly
            100                 105                 110         
Lys Met Val Ala Glu Cys Lys Met Lys Gly Val Val Cys Thr Arg Ile
        115                 120                 125             
Tyr Glu Lys Val
    130         


<210> 481
<211> 932
<212> PRT
<213> Homo sapiens

<400> 481
Met Lys Gln Leu Pro Ala Ala Thr Val Arg Leu Leu Ser Ser Ser Gln
 1               5                  10                  15      
Ile Ile Thr Ser Val Val Ser Val Val Lys Glu Leu Ile Glu Asn Ser
            20                  25                  30          
Leu Asp Ala Gly Ala Thr Ser Val Asp Val Lys Leu Glu Asn Tyr Gly
        35                  40                  45              
Phe Asp Lys Ile Glu Val Arg Asp Asn Gly Glu Gly Ile Lys Ala Val
    50                  55                  60                  
Asp Ala Pro Val Met Ala Met Lys Tyr Tyr Thr Ser Lys Ile Asn Ser
65                  70                  75                  80  
His Glu Asp Leu Glu Asn Leu Thr Thr Tyr Gly Phe Arg Gly Glu Ala
                85                  90                  95      
Leu Gly Ser Ile Cys Cys Ile Ala Glu Val Leu Ile Thr Thr Arg Thr
            100                 105                 110         
Ala Ala Asp Asn Phe Ser Thr Gln Tyr Val Leu Asp Gly Ser Gly His
        115                 120                 125             
Ile Leu Ser Gln Lys Pro Ser His Leu Gly Gln Gly Thr Thr Val Thr
    130                 135                 140                 
Ala Leu Arg Leu Phe Lys Asn Leu Pro Val Arg Lys Gln Phe Tyr Ser
145                 150                 155                 160 
Thr Ala Lys Lys Cys Lys Asp Glu Ile Lys Lys Ile Gln Asp Leu Leu
                165                 170                 175     
Met Ser Phe Gly Ile Leu Lys Pro Asp Leu Arg Ile Val Phe Val His
            180                 185                 190         
Asn Lys Ala Val Ile Trp Gln Lys Ser Arg Val Ser Asp His Lys Met
        195                 200                 205             
Ala Leu Met Ser Val Leu Gly Thr Ala Val Met Asn Asn Met Glu Ser
    210                 215                 220                 
Phe Gln Tyr His Ser Glu Glu Ser Gln Ile Tyr Leu Ser Gly Phe Leu
225                 230                 235                 240 
Pro Lys Cys Asp Ala Asp His Ser Phe Thr Ser Leu Ser Thr Pro Glu
                245                 250                 255     
Arg Ser Phe Ile Phe Ile Asn Ser Arg Pro Val His Gln Lys Asp Ile
            260                 265                 270         
Leu Lys Leu Ile Arg His His Tyr Asn Leu Lys Cys Leu Lys Glu Ser
        275                 280                 285             
Thr Arg Leu Tyr Pro Val Phe Phe Leu Lys Ile Asp Val Pro Thr Ala
    290                 295                 300                 
Asp Val Asp Val Asn Leu Thr Pro Asp Lys Ser Gln Val Leu Leu Gln
305                 310                 315                 320 
Asn Lys Glu Ser Val Leu Ile Ala Leu Glu Asn Leu Met Thr Thr Cys
                325                 330                 335     
Tyr Gly Pro Leu Pro Ser Thr Asn Ser Tyr Glu Asn Asn Lys Thr Asp
            340                 345                 350         
Val Ser Ala Ala Asp Ile Val Leu Ser Lys Thr Ala Glu Thr Asp Val
        355                 360                 365             
Leu Phe Asn Lys Val Glu Ser Ser Gly Lys Asn Tyr Ser Asn Val Asp
    370                 375                 380                 
Thr Ser Val Ile Pro Phe Gln Asn Asp Met His Asn Asp Glu Ser Gly
385                 390                 395                 400 
Lys Asn Thr Asp Asp Cys Leu Asn His Gln Ile Ser Ile Gly Asp Phe
                405                 410                 415     
Gly Tyr Gly His Cys Ser Ser Glu Ile Ser Asn Ile Asp Lys Asn Thr
            420                 425                 430         
Lys Asn Ala Phe Gln Asp Ile Ser Met Ser Asn Val Ser Trp Glu Asn
        435                 440                 445             
Ser Gln Thr Glu Tyr Ser Lys Thr Cys Phe Ile Ser Ser Val Lys His
    450                 455                 460                 
Thr Gln Ser Glu Asn Gly Asn Lys Asp His Ile Asp Glu Ser Gly Glu
465                 470                 475                 480 
Asn Glu Glu Glu Ala Gly Leu Glu Asn Ser Ser Glu Ile Ser Ala Asp
                485                 490                 495     
Glu Trp Ser Arg Gly Asn Ile Leu Lys Asn Ser Val Gly Glu Asn Ile
            500                 505                 510         
Glu Pro Val Lys Ile Leu Val Pro Glu Lys Ser Leu Pro Cys Lys Val
        515                 520                 525             
Ser Asn Asn Asn Tyr Pro Ile Pro Glu Gln Met Asn Leu Asn Glu Asp
    530                 535                 540                 
Ser Cys Asn Lys Lys Ser Asn Val Ile Asp Asn Lys Ser Gly Lys Val
545                 550                 555                 560 
Thr Ala Tyr Asp Leu Leu Ser Asn Arg Val Ile Lys Lys Pro Met Ser
                565                 570                 575     
Ala Ser Ala Leu Phe Val Gln Asp His Arg Pro Gln Phe Leu Ile Glu
            580                 585                 590         
Asn Pro Lys Thr Ser Leu Glu Asp Ala Thr Leu Gln Ile Glu Glu Leu
        595                 600                 605             
Trp Lys Thr Leu Ser Glu Glu Glu Lys Leu Lys Tyr Glu Glu Lys Ala
    610                 615                 620                 
Thr Lys Asp Leu Glu Arg Tyr Asn Ser Gln Met Lys Arg Ala Ile Glu
625                 630                 635                 640 
Gln Glu Ser Gln Met Ser Leu Lys Asp Gly Arg Lys Lys Ile Lys Pro
                645                 650                 655     
Thr Ser Ala Trp Asn Leu Ala Gln Lys His Lys Leu Lys Thr Ser Leu
            660                 665                 670         
Ser Asn Gln Pro Lys Leu Asp Glu Leu Leu Gln Ser Gln Ile Glu Lys
        675                 680                 685             
Arg Arg Ser Gln Asn Ile Lys Met Val Gln Ile Pro Phe Ser Met Lys
    690                 695                 700                 
Asn Leu Lys Ile Asn Phe Lys Lys Gln Asn Lys Val Asp Leu Glu Glu
705                 710                 715                 720 
Lys Asp Glu Pro Cys Leu Ile His Asn Leu Arg Phe Pro Asp Ala Trp
                725                 730                 735     
Leu Met Thr Ser Lys Thr Glu Val Met Leu Leu Asn Pro Tyr Arg Val
            740                 745                 750         
Glu Glu Ala Leu Leu Phe Lys Arg Leu Leu Glu Asn His Lys Leu Pro
        755                 760                 765             
Ala Glu Pro Leu Glu Lys Pro Ile Met Leu Thr Glu Ser Leu Phe Asn
    770                 775                 780                 
Gly Ser His Tyr Leu Asp Val Leu Tyr Lys Met Thr Ala Asp Asp Gln
785                 790                 795                 800 
Arg Tyr Ser Gly Ser Thr Tyr Leu Ser Asp Pro Arg Leu Thr Ala Asn
                805                 810                 815     
Gly Phe Lys Ile Lys Leu Ile Pro Gly Val Ser Ile Thr Glu Asn Tyr
            820                 825                 830         
Leu Glu Ile Glu Gly Met Ala Asn Cys Leu Pro Phe Tyr Gly Val Ala
        835                 840                 845             
Asp Leu Lys Glu Ile Leu Asn Ala Ile Leu Asn Arg Asn Ala Lys Glu
    850                 855                 860                 
Val Tyr Glu Cys Arg Pro Arg Lys Val Ile Ser Tyr Leu Glu Gly Glu
865                 870                 875                 880 
Ala Val Arg Leu Ser Arg Gln Leu Pro Met Tyr Leu Ser Lys Glu Asp
                885                 890                 895     
Ile Gln Asp Ile Ile Tyr Arg Met Lys His Gln Phe Gly Asn Glu Ile
            900                 905                 910         
Lys Glu Cys Val His Gly Arg Pro Phe Phe His His Leu Thr Tyr Leu
        915                 920                 925             
Pro Glu Thr Thr
    930         


<210> 482
<211> 337
<212> PRT
<213> Homo sapiens

<400> 482
Met Arg Ala Val Phe Ile Gln Gly Ala Glu Glu His Pro Ala Ala Phe
 1               5                  10                  15      
Cys Tyr Gln Val Asn Gly Ser Cys Pro Arg Thr Val His Thr Leu Gly
            20                  25                  30          
Ile Gln Leu Val Ile Tyr Leu Thr Cys Ala Ala Gly Met Leu Ile Ile
        35                  40                  45              
Val Leu Gly Asn Val Phe Val Ala Phe Ala Val Ser Tyr Phe Lys Ala
    50                  55                  60                  
Leu His Thr Pro Thr Asn Phe Leu Leu Leu Ser Leu Ala Leu Ala Asp
65                  70                  75                  80  
Met Phe Leu Gly Leu Leu Val Leu Pro Leu Ser Thr Ile Arg Ser Val
                85                  90                  95      
Glu Ser Cys Trp Phe Phe Gly Asp Phe Leu Cys Arg Leu His Thr Tyr
            100                 105                 110         
Leu Asp Thr Leu Phe Cys Leu Thr Ser Ile Phe His Leu Cys Phe Ile
        115                 120                 125             
Ser Ile Asp Arg His Cys Ala Ile Cys Asp Pro Leu Leu Tyr Pro Ser
    130                 135                 140                 
Lys Phe Thr Val Arg Val Ala Leu Arg Tyr Ile Leu Ala Gly Trp Gly
145                 150                 155                 160 
Val Pro Ala Ala Tyr Thr Ser Leu Phe Leu Tyr Thr Asp Val Val Glu
                165                 170                 175     
Thr Arg Leu Ser Gln Trp Leu Glu Glu Met Pro Cys Val Gly Ser Cys
            180                 185                 190         
Gln Leu Leu Leu Asn Lys Phe Trp Gly Trp Leu Asn Phe Pro Leu Phe
        195                 200                 205             
Phe Val Pro Cys Leu Ile Met Ile Ser Leu Tyr Val Lys Ile Phe Val
    210                 215                 220                 
Val Ala Thr Arg Gln Ala Gln Gln Ile Thr Thr Leu Ser Lys Ser Leu
225                 230                 235                 240 
Ala Gly Ala Ala Lys His Glu Arg Lys Ala Ala Lys Thr Leu Gly Ile
                245                 250                 255     
Val Val Gly Ile Tyr Leu Leu Cys Trp Leu Pro Phe Thr Ile Asp Thr
            260                 265                 270         
Met Val Asp Ser Leu Leu His Phe Ile Thr Pro Pro Leu Val Phe Asp
        275                 280                 285             
Ile Phe Ile Trp Phe Ala Tyr Phe Asn Ser Ala Cys Asn Pro Ile Ile
    290                 295                 300                 
Tyr Val Phe Ser Tyr Gln Trp Phe Arg Lys Ala Leu Lys Leu Thr Leu
305                 310                 315                 320 
Ser Gln Lys Val Phe Ser Pro Gln Thr Arg Thr Val Asp Leu Tyr Gln
                325                 330                 335     
Glu
    


<210> 483
<211> 338
<212> PRT
<213> Homo sapiens

<400> 483
Met Met Ala Met Asn Ser Lys Gln Pro Phe Gly Met His Pro Val Leu
 1               5                  10                  15      
Gln Glu Pro Lys Phe Ser Ser Leu His Ser Gly Ser Glu Ala Met Arg
            20                  25                  30          
Arg Val Cys Leu Pro Ala Pro Gln Leu Gln Gly Asn Ile Phe Gly Ser
        35                  40                  45              
Phe Asp Glu Ser Leu Leu Ala Arg Ala Glu Ala Leu Ala Ala Val Asp
    50                  55                  60                  
Ile Val Ser His Gly Lys Asn His Pro Phe Lys Pro Asp Ala Thr Tyr
65                  70                  75                  80  
His Thr Met Ser Ser Val Pro Cys Thr Ser Thr Ser Ser Thr Val Pro
                85                  90                  95      
Ile Ser His Pro Ala Ala Leu Thr Ser His Pro His His Ala Val His
            100                 105                 110         
Gln Gly Leu Glu Gly Asp Leu Leu Glu His Ile Ser Pro Thr Leu Ser
        115                 120                 125             
Val Ser Gly Leu Gly Ala Pro Glu His Ser Val Met Pro Ala Gln Ile
    130                 135                 140                 
His Pro His His Leu Gly Ala Met Gly His Leu His Gln Ala Met Gly
145                 150                 155                 160 
Met Ser His Pro His Thr Val Ala Pro His Ser Ala Met Pro Ala Cys
                165                 170                 175     
Leu Ser Asp Val Glu Ser Asp Pro Arg Glu Leu Glu Ala Phe Ala Glu
            180                 185                 190         
Arg Phe Lys Gln Arg Arg Ile Lys Leu Gly Val Thr Gln Ala Asp Val
        195                 200                 205             
Gly Ala Ala Leu Ala Asn Leu Lys Ile Pro Gly Val Gly Ser Leu Ser
    210                 215                 220                 
Gln Ser Thr Ile Cys Arg Phe Glu Ser Leu Thr Leu Ser His Asn Asn
225                 230                 235                 240 
Met Ile Ala Leu Lys Pro Val Leu Gln Ala Trp Leu Glu Glu Ala Glu
                245                 250                 255     
Ala Ala Tyr Arg Glu Lys Asn Ser Lys Pro Glu Leu Phe Asn Gly Ser
            260                 265                 270         
Glu Arg Lys Arg Lys Arg Thr Ser Ile Ala Ala Pro Glu Lys Arg Ser
        275                 280                 285             
Leu Glu Ala Tyr Phe Ala Ile Gln Pro Arg Pro Ser Ser Glu Lys Ile
    290                 295                 300                 
Ala Ala Ile Ala Glu Lys Leu Asp Leu Lys Lys Asn Val Val Arg Val
305                 310                 315                 320 
Trp Phe Cys Asn Gln Arg Gln Lys Gln Lys Arg Met Lys Tyr Ser Ala
                325                 330                 335     
Val His
        


<210> 484
<211> 527
<212> PRT
<213> Homo sapiens

<400> 484
Met Leu Leu Pro Leu Leu Leu Leu Leu Pro Met Cys Trp Ala Val Glu
 1               5                  10                  15      
Val Lys Arg Pro Arg Gly Val Ser Leu Thr Asn His His Phe Tyr Asp
            20                  25                  30          
Glu Ser Lys Pro Phe Thr Cys Leu Asp Gly Ser Ala Thr Ile Pro Phe
        35                  40                  45              
Asp Gln Val Asn Asp Asp Tyr Cys Asp Cys Lys Asp Gly Ser Asp Glu
    50                  55                  60                  
Pro Gly Thr Ala Ala Cys Pro Asn Gly Ser Phe His Cys Thr Asn Thr
65                  70                  75                  80  
Gly Tyr Lys Pro Leu Tyr Ile Pro Ser Asn Arg Val Asn Asp Gly Val
                85                  90                  95      
Cys Asp Cys Cys Asp Gly Thr Asp Glu Tyr Asn Ser Gly Val Ile Cys
            100                 105                 110         
Glu Asn Thr Cys Lys Glu Lys Gly Arg Lys Glu Arg Glu Ser Leu Gln
        115                 120                 125             
Gln Met Ala Glu Val Thr Arg Glu Gly Phe Arg Leu Lys Lys Ile Leu
    130                 135                 140                 
Ile Glu Asp Trp Lys Lys Ala Arg Glu Glu Lys Gln Lys Lys Leu Ile
145                 150                 155                 160 
Glu Leu Gln Ala Gly Lys Lys Ser Leu Glu Asp Gln Val Glu Met Leu
                165                 170                 175     
Arg Thr Val Lys Glu Glu Ala Glu Lys Pro Glu Arg Glu Ala Lys Glu
            180                 185                 190         
Gln His Gln Lys Leu Trp Glu Glu Gln Leu Ala Ala Ala Lys Ala Gln
        195                 200                 205             
Gln Glu Gln Glu Leu Ala Ala Asp Ala Phe Lys Glu Leu Asp Asp Asp
    210                 215                 220                 
Met Asp Gly Thr Val Ser Val Thr Glu Leu Gln Thr His Pro Glu Leu
225                 230                 235                 240 
Asp Thr Asp Gly Asp Gly Ala Leu Ser Glu Ala Glu Ala Gln Ala Leu
                245                 250                 255     
Leu Ser Gly Asp Thr Gln Thr Asp Ala Thr Ser Phe Tyr Asp Arg Val
            260                 265                 270         
Trp Ala Ala Ile Arg Asp Lys Tyr Arg Ser Glu Ala Leu Pro Thr Asp
        275                 280                 285             
Leu Pro Ala Pro Ser Ala Pro Asp Leu Thr Glu Pro Lys Glu Glu Gln
    290                 295                 300                 
Pro Pro Val Pro Ser Ser Pro Thr Glu Glu Glu Glu Glu Glu Glu Glu
305                 310                 315                 320 
Glu Glu Glu Glu Ala Glu Glu Glu Glu Glu Glu Glu Asp Ser Glu Glu
                325                 330                 335     
Ala Pro Pro Pro Leu Ser Pro Pro Gln Pro Ala Ser Pro Ala Glu Glu
            340                 345                 350         
Asp Lys Met Pro Pro Tyr Asp Glu Gln Thr Gln Ala Phe Ile Asp Ala
        355                 360                 365             
Ala Gln Glu Ala Arg Asn Lys Phe Glu Glu Ala Glu Arg Ser Leu Lys
    370                 375                 380                 
Asp Met Glu Glu Ser Ile Arg Asn Leu Glu Gln Glu Ile Ser Phe Asp
385                 390                 395                 400 
Phe Gly Pro Asn Gly Glu Phe Ala Tyr Leu Tyr Ser Gln Cys Tyr Glu
                405                 410                 415     
Leu Thr Thr Asn Glu Tyr Val Tyr Arg Leu Cys Pro Phe Lys Leu Val
            420                 425                 430         
Ser Gln Lys Pro Lys Leu Gly Gly Ser Pro Thr Ser Leu Gly Thr Trp
        435                 440                 445             
Gly Ser Trp Ile Gly Pro Asp His Asp Lys Phe Ser Ala Met Lys Tyr
    450                 455                 460                 
Glu Gln Gly Thr Gly Cys Trp Gln Gly Pro Asn Arg Ser Thr Thr Val
465                 470                 475                 480 
Arg Leu Leu Cys Gly Lys Glu Thr Met Val Thr Ser Thr Thr Glu Pro
                485                 490                 495     
Ser Arg Cys Glu Tyr Leu Met Glu Leu Met Thr Pro Ala Ala Cys Pro
            500                 505                 510         
Glu Pro Pro Pro Glu Ala Pro Thr Glu Asp Asp His Asp Glu Leu
        515                 520                 525         


<210> 485
<211> 721
<212> PRT
<213> Homo sapiens

<400> 485
Met Ala Glu Lys Phe Glu Ser Leu Met Asn Ile His Gly Phe Asp Leu
 1               5                  10                  15      
Gly Ser Arg Tyr Met Asp Leu Lys Pro Leu Gly Cys Gly Gly Asn Gly
            20                  25                  30          
Leu Val Phe Ser Ala Val Asp Asn Asp Cys Asp Lys Arg Val Ala Ile
        35                  40                  45              
Lys Lys Ile Val Leu Thr Asp Pro Gln Ser Val Lys His Ala Leu Arg
    50                  55                  60                  
Glu Ile Lys Ile Ile Arg Arg Leu Asp His Asp Asn Ile Val Lys Val
65                  70                  75                  80  
Phe Glu Ile Leu Gly Pro Ser Gly Ser Gln Leu Thr Asp Asp Val Gly
                85                  90                  95      
Ser Leu Thr Glu Leu Asn Ser Val Tyr Ile Val Gln Glu Tyr Met Glu
            100                 105                 110         
Thr Asp Leu Ala Asn Val Leu Glu Gln Gly Pro Leu Leu Glu Glu His
        115                 120                 125             
Ala Arg Leu Phe Met Tyr Gln Leu Leu Arg Gly Leu Lys Tyr Ile His
    130                 135                 140                 
Ser Ala Asn Val Leu His Arg Asp Leu Lys Pro Ala Asn Leu Phe Ile
145                 150                 155                 160 
Asn Thr Glu Asp Leu Val Leu Lys Ile Gly Asp Phe Gly Leu Ala Arg
                165                 170                 175     
Ile Met Asp Pro His Tyr Ser His Lys Gly His Leu Ser Glu Gly Leu
            180                 185                 190         
Val Thr Lys Trp Tyr Arg Ser Pro Arg Leu Leu Leu Ser Pro Asn Asn
        195                 200                 205             
Tyr Thr Lys Ala Ile Asp Met Trp Ala Ala Gly Cys Ile Phe Ala Glu
    210                 215                 220                 
Met Leu Thr Gly Lys Thr Leu Phe Ala Gly Ala His Glu Leu Glu Gln
225                 230                 235                 240 
Met Gln Leu Ile Leu Glu Ser Ile Pro Val Val His Glu Glu Asp Arg
                245                 250                 255     
Gln Glu Leu Leu Ser Val Ile Pro Val Tyr Ile Arg Asn Asp Met Thr
            260                 265                 270         
Glu Pro His Lys Pro Leu Thr Gln Leu Leu Pro Gly Ile Ser Arg Glu
        275                 280                 285             
Ala Leu Asp Phe Leu Glu Gln Ile Leu Thr Phe Ser Pro Met Asp Arg
    290                 295                 300                 
Leu Thr Ala Glu Glu Ala Leu Ser His Pro Tyr Met Ser Ile Tyr Ser
305                 310                 315                 320 
Phe Pro Met Asp Glu Pro Ile Ser Ser His Pro Phe His Ile Glu Asp
                325                 330                 335     
Glu Val Asp Asp Ile Leu Leu Met Asp Glu Thr His Ser His Ile Tyr
            340                 345                 350         
Asn Trp Glu Arg Tyr His Asp Cys Gln Phe Ser Glu His Asp Trp Pro
        355                 360                 365             
Val His Asn Asn Phe Asp Ile Asp Glu Val Gln Leu Asp Pro Arg Ala
    370                 375                 380                 
Leu Ser Asp Val Thr Asp Glu Glu Glu Val Gln Val Asp Pro Arg Lys
385                 390                 395                 400 
Tyr Leu Asp Gly Asp Arg Glu Lys Tyr Leu Glu Asp Pro Ala Phe Asp
                405                 410                 415     
Thr Asn Tyr Ser Thr Glu Pro Cys Trp Gln Tyr Ser Asp His His Glu
            420                 425                 430         
Asn Lys Tyr Cys Asp Leu Glu Cys Ser His Thr Cys Asn Tyr Lys Thr
        435                 440                 445             
Arg Ser Ser Ser Tyr Leu Asp Asn Leu Val Trp Arg Glu Ser Glu Val
    450                 455                 460                 
Asn His Tyr Tyr Glu Pro Lys Leu Ile Ile Asp Leu Ser Asn Trp Lys
465                 470                 475                 480 
Glu Gln Ser Lys Glu Lys Ser Asp Lys Lys Gly Lys Ser Lys Cys Glu
                485                 490                 495     
Arg Asn Gly Leu Val Lys Ala Gln Ile Ala Leu Glu Glu Ala Ser Gln
            500                 505                 510         
Gln Leu Ala Gly Lys Glu Arg Glu Lys Asn Gln Gly Phe Asp Phe Asp
        515                 520                 525             
Ser Phe Ile Ala Gly Thr Ile Gln Leu Ser Ser Gln His Glu Pro Thr
    530                 535                 540                 
Asp Val Val Asp Lys Leu Asn Asp Leu Asn Ser Ser Val Ser Gln Leu
545                 550                 555                 560 
Glu Leu Lys Ser Leu Ile Ser Lys Ser Val Ser Gln Glu Lys Gln Glu
                565                 570                 575     
Lys Gly Met Ala Asn Leu Ala Gln Leu Glu Ala Leu Tyr Gln Ser Ser
            580                 585                 590         
Trp Asp Ser Gln Phe Val Ser Gly Gly Glu Asp Cys Phe Phe Ile Asn
        595                 600                 605             
Gln Phe Cys Glu Val Arg Lys Asp Glu Gln Val Glu Lys Glu Asn Thr
    610                 615                 620                 
Tyr Thr Ser Tyr Leu Asp Lys Phe Phe Ser Arg Lys Glu Asp Thr Glu
625                 630                 635                 640 
Met Leu Glu Thr Glu Pro Val Glu Asp Gly Lys Leu Gly Glu Arg Gly
                645                 650                 655     
His Glu Glu Gly Phe Leu Asn Asn Ser Gly Glu Phe Leu Phe Asn Lys
            660                 665                 670         
Gln Leu Glu Ser Ile Gly Ile Pro Gln Phe His Ser Pro Val Gly Ser
        675                 680                 685             
Pro Leu Lys Ser Ile Gln Ala Thr Leu Thr Pro Ser Ala Met Lys Ser
    690                 695                 700                 
Ser Pro Gln Ile Pro His Gln Thr Tyr Ser Ser Ile Leu Lys His Leu
705                 710                 715                 720 
Asn
    


<210> 486
<211> 248
<212> PRT
<213> Homo sapiens

<400> 486
Met Ser Tyr Asp Arg Ala Ile Thr Val Phe Ser Pro Asp Gly His Leu
 1               5                  10                  15      
Phe Gln Val Glu Tyr Ala Gln Glu Ala Val Lys Lys Gly Ser Thr Ala
            20                  25                  30          
Val Gly Val Arg Gly Arg Asp Ile Val Val Leu Gly Val Glu Lys Lys
        35                  40                  45              
Ser Val Ala Lys Leu Gln Asp Glu Arg Thr Val Arg Lys Ile Cys Ala
    50                  55                  60                  
Leu Asp Asp Asn Val Cys Met Ala Phe Ala Gly Leu Thr Ala Asp Ala
65                  70                  75                  80  
Arg Ile Val Ile Asn Arg Ala Arg Val Glu Cys Gln Ser His Arg Leu
                85                  90                  95      
Thr Val Glu Asp Pro Val Thr Val Glu Tyr Ile Thr Arg Tyr Ile Ala
            100                 105                 110         
Ser Leu Lys Gln Arg Tyr Thr Gln Ser Asn Gly Arg Arg Pro Phe Gly
        115                 120                 125             
Ile Ser Ala Leu Ile Val Gly Phe Asp Phe Asp Gly Thr Pro Arg Leu
    130                 135                 140                 
Tyr Gln Thr Asp Pro Ser Gly Thr Tyr His Ala Trp Lys Ala Asn Ala
145                 150                 155                 160 
Ile Gly Arg Gly Ala Lys Ser Val Arg Glu Phe Leu Glu Lys Asn Tyr
                165                 170                 175     
Thr Asp Glu Ala Ile Glu Thr Asp Asp Leu Thr Ile Lys Leu Val Ile
            180                 185                 190         
Lys Ala Leu Leu Glu Val Val Gln Ser Gly Gly Lys Asn Ile Glu Leu
        195                 200                 205             
Ala Val Met Arg Arg Asp Gln Ser Leu Lys Ile Leu Asn Pro Glu Glu
    210                 215                 220                 
Ile Glu Lys Tyr Val Ala Glu Ile Glu Lys Glu Lys Glu Glu Asn Glu
225                 230                 235                 240 
Lys Lys Lys Gln Lys Lys Ala Ser
                245             


<210> 487
<211> 205
<212> PRT
<213> Homo sapiens

<400> 487
Met Ser Ile Met Ser Tyr Asn Gly Gly Ala Val Met Ala Met Lys Gly
 1               5                  10                  15      
Lys Asn Cys Val Ala Ile Ala Ala Asp Arg Arg Phe Gly Ile Gln Ala
            20                  25                  30          
Gln Leu Val Thr Thr Asp Phe Gln Lys Ile Phe Pro Met Gly Asp Arg
        35                  40                  45              
Leu Tyr Ile Gly Leu Ala Gly Leu Ala Thr Asp Val Gln Thr Val Ala
    50                  55                  60                  
Gln Arg Leu Lys Phe Arg Leu Asn Leu Tyr Glu Leu Lys Glu Gly Arg
65                  70                  75                  80  
Gln Ile Lys Pro Tyr Thr Leu Met Ser Met Val Ala Asn Leu Leu Tyr
                85                  90                  95      
Glu Lys Arg Phe Gly Pro Tyr Tyr Thr Glu Pro Val Ile Ala Gly Leu
            100                 105                 110         
Asp Pro Lys Thr Phe Lys Pro Phe Ile Cys Ser Leu Asp Leu Ile Gly
        115                 120                 125             
Cys Pro Met Val Thr Asp Asp Phe Val Val Ser Gly Thr Cys Ala Glu
    130                 135                 140                 
Gln Met Tyr Gly Met Cys Glu Ser Leu Trp Glu Pro Asn Met Asp Pro
145                 150                 155                 160 
Asp His Leu Phe Glu Thr Ile Ser Gln Ala Met Leu Asn Ala Val Asp
                165                 170                 175     
Arg Asp Ala Val Ser Gly Met Gly Val Ile Val His Ile Ile Glu Lys
            180                 185                 190         
Asp Lys Ile Thr Thr Arg Thr Leu Lys Ala Arg Met Asp
        195                 200                 205 


<210> 488
<211> 415
<212> PRT
<213> Homo sapiens

<400> 488
Met Pro Thr Thr Ile Glu Arg Glu Phe Glu Glu Leu Asp Thr Gln Arg
 1               5                  10                  15      
Arg Trp Gln Pro Leu Tyr Leu Glu Ile Arg Asn Glu Ser His Asp Tyr
            20                  25                  30          
Pro His Arg Val Ala Lys Phe Pro Glu Asn Arg Asn Arg Asn Arg Tyr
        35                  40                  45              
Arg Asp Val Ser Pro Tyr Asp His Ser Arg Val Lys Leu Gln Asn Ala
    50                  55                  60                  
Glu Asn Asp Tyr Ile Asn Ala Ser Leu Val Asp Ile Glu Glu Ala Gln
65                  70                  75                  80  
Arg Ser Tyr Ile Leu Thr Gln Gly Pro Leu Pro Asn Thr Cys Cys His
                85                  90                  95      
Phe Trp Leu Met Val Trp Gln Gln Lys Thr Lys Ala Val Val Met Leu
            100                 105                 110         
Asn Arg Ile Val Glu Lys Glu Ser Val Lys Cys Ala Gln Tyr Trp Pro
        115                 120                 125             
Thr Asp Asp Gln Glu Met Leu Phe Lys Glu Thr Gly Phe Ser Val Lys
    130                 135                 140                 
Leu Leu Ser Glu Asp Val Lys Ser Tyr Tyr Thr Val His Leu Leu Gln
145                 150                 155                 160 
Leu Glu Asn Ile Asn Ser Gly Glu Thr Arg Thr Ile Ser His Phe His
                165                 170                 175     
Tyr Thr Thr Trp Pro Asp Phe Gly Val Pro Glu Ser Pro Ala Ser Phe
            180                 185                 190         
Leu Asn Phe Leu Phe Lys Val Arg Glu Ser Gly Ser Leu Asn Pro Asp
        195                 200                 205             
His Gly Pro Ala Val Ile His Cys Ser Ala Gly Ile Gly Arg Ser Gly
    210                 215                 220                 
Thr Phe Ser Leu Val Asp Thr Cys Leu Val Leu Met Glu Lys Gly Asp
225                 230                 235                 240 
Asp Ile Asn Ile Lys Gln Val Leu Leu Asn Met Arg Lys Tyr Arg Met
                245                 250                 255     
Gly Leu Ile Gln Thr Pro Asp Gln Leu Arg Phe Ser Tyr Met Ala Ile
            260                 265                 270         
Ile Glu Gly Ala Lys Cys Ile Lys Gly Asp Ser Ser Ile Gln Lys Arg
        275                 280                 285             
Trp Lys Glu Leu Ser Lys Glu Asp Leu Ser Pro Ala Phe Asp His Ser
    290                 295                 300                 
Pro Asn Lys Ile Met Thr Glu Lys Tyr Asn Gly Asn Arg Ile Gly Leu
305                 310                 315                 320 
Glu Glu Glu Lys Leu Thr Gly Asp Arg Cys Thr Gly Leu Ser Ser Lys
                325                 330                 335     
Met Gln Asp Thr Met Glu Glu Asn Ser Glu Ser Ala Leu Arg Lys Arg
            340                 345                 350         
Ile Arg Glu Asp Arg Lys Ala Thr Thr Ala Gln Lys Val Gln Gln Met
        355                 360                 365             
Lys Gln Arg Leu Asn Glu Asn Glu Arg Lys Arg Lys Arg Trp Leu Tyr
    370                 375                 380                 
Trp Gln Pro Ile Leu Thr Lys Met Gly Phe Met Ser Val Ile Leu Val
385                 390                 395                 400 
Gly Ala Phe Val Gly Trp Arg Leu Phe Phe Gln Gln Asn Ala Leu
                405                 410                 415 


<210> 489
<211> 215
<212> PRT
<213> Homo sapiens

<400> 489
Met Thr Ser Arg Ser Thr Ala Arg Pro Asn Gly Gln Pro Gln Ala Ser
 1               5                  10                  15      
Lys Ile Cys Gln Phe Lys Leu Val Leu Leu Gly Glu Ser Ala Val Gly
            20                  25                  30          
Lys Ser Ser Leu Val Leu Arg Phe Val Lys Gly Gln Phe His Glu Tyr
        35                  40                  45              
Gln Glu Ser Thr Ile Gly Ala Ala Phe Leu Thr Gln Ser Val Cys Leu
    50                  55                  60                  
Asp Asp Thr Thr Val Lys Phe Glu Ile Trp Asp Thr Ala Gly Gln Glu
65                  70                  75                  80  
Arg Tyr His Ser Leu Ala Pro Met Tyr Tyr Arg Gly Ala Gln Ala Ala
                85                  90                  95      
Ile Val Val Tyr Asp Ile Thr Asn Gln Glu Thr Phe Ala Arg Ala Lys
            100                 105                 110         
Thr Trp Val Lys Glu Leu Gln Arg Gln Ala Ser Pro Ser Ile Val Ile
        115                 120                 125             
Ala Leu Ala Gly Asn Lys Ala Asp Leu Ala Asn Lys Arg Met Val Glu
    130                 135                 140                 
Tyr Glu Glu Ala Gln Ala Tyr Ala Asp Asp Asn Ser Leu Leu Phe Met
145                 150                 155                 160 
Glu Thr Ser Ala Lys Thr Ala Met Asn Val Asn Asp Leu Phe Leu Ala
                165                 170                 175     
Ile Ala Lys Lys Leu Pro Lys Ser Glu Pro Gln Asn Leu Gly Gly Ala
            180                 185                 190         
Ala Gly Arg Ser Arg Gly Val Asp Leu His Glu Gln Ser Gln Gln Asn
        195                 200                 205             
Lys Ser Gln Cys Cys Ser Asn
    210                 215 


<210> 490
<211> 648
<212> PRT
<213> Homo sapiens

<400> 490
Met Glu His Ile Gln Gly Ala Trp Lys Thr Ile Ser Asn Gly Phe Gly
 1               5                  10                  15      
Phe Lys Asp Ala Val Phe Asp Gly Ser Ser Cys Ile Ser Pro Thr Ile
            20                  25                  30          
Val Gln Gln Phe Gly Tyr Gln Arg Arg Ala Ser Asp Asp Gly Lys Leu
        35                  40                  45              
Thr Asp Pro Ser Lys Thr Ser Asn Thr Ile Arg Val Phe Leu Pro Asn
    50                  55                  60                  
Lys Gln Arg Thr Val Val Asn Val Arg Asn Gly Met Ser Leu His Asp
65                  70                  75                  80  
Cys Leu Met Lys Ala Leu Lys Val Arg Gly Leu Gln Pro Glu Cys Cys
                85                  90                  95      
Ala Val Phe Arg Leu Leu His Glu His Lys Gly Lys Lys Ala Arg Leu
            100                 105                 110         
Asp Trp Asn Thr Asp Ala Ala Ser Leu Ile Gly Glu Glu Leu Gln Val
        115                 120                 125             
Asp Phe Leu Asp His Val Pro Leu Thr Thr His Asn Phe Ala Arg Lys
    130                 135                 140                 
Thr Phe Leu Lys Leu Ala Phe Cys Asp Ile Cys Gln Lys Phe Leu Leu
145                 150                 155                 160 
Asn Gly Phe Arg Cys Gln Thr Cys Gly Tyr Lys Phe His Glu His Cys
                165                 170                 175     
Ser Thr Lys Val Pro Thr Met Cys Val Asp Trp Ser Asn Ile Arg Gln
            180                 185                 190         
Leu Leu Leu Phe Pro Asn Ser Thr Ile Gly Asp Ser Gly Val Pro Ala
        195                 200                 205             
Leu Pro Ser Leu Thr Met Arg Arg Met Arg Glu Ser Val Ser Arg Met
    210                 215                 220                 
Pro Val Ser Ser Gln His Arg Tyr Ser Thr Pro His Ala Phe Thr Phe
225                 230                 235                 240 
Asn Thr Ser Ser Pro Ser Ser Glu Gly Ser Leu Ser Gln Arg Gln Arg
                245                 250                 255     
Ser Thr Ser Thr Pro Asn Val His Met Val Ser Thr Thr Leu Pro Val
            260                 265                 270         
Asp Ser Arg Met Ile Glu Asp Ala Ile Arg Ser His Ser Glu Ser Ala
        275                 280                 285             
Ser Pro Ser Ala Leu Ser Ser Ser Pro Asn Asn Leu Ser Pro Thr Gly
    290                 295                 300                 
Trp Ser Gln Pro Lys Thr Pro Val Pro Ala Gln Arg Glu Arg Ala Pro
305                 310                 315                 320 
Val Ser Gly Thr Gln Glu Lys Asn Lys Ile Arg Pro Arg Gly Gln Arg
                325                 330                 335     
Asp Ser Ser Tyr Tyr Trp Glu Ile Glu Ala Ser Glu Val Met Leu Ser
            340                 345                 350         
Thr Arg Ile Gly Ser Gly Ser Phe Gly Thr Val Tyr Lys Gly Lys Trp
        355                 360                 365             
His Gly Asp Val Ala Val Lys Ile Leu Lys Val Val Asp Pro Thr Pro
    370                 375                 380                 
Glu Gln Phe Gln Ala Phe Arg Asn Glu Val Ala Val Leu Arg Lys Thr
385                 390                 395                 400 
Arg His Val Asn Ile Leu Leu Phe Met Gly Tyr Met Thr Lys Asp Asn
                405                 410                 415     
Leu Ala Ile Val Thr Gln Trp Cys Glu Gly Ser Ser Leu Tyr Lys His
            420                 425                 430         
Leu His Val Gln Glu Thr Lys Phe Gln Met Phe Gln Leu Ile Asp Ile
        435                 440                 445             
Ala Arg Gln Thr Ala Gln Gly Met Asp Tyr Leu His Ala Lys Asn Ile
    450                 455                 460                 
Ile His Arg Asp Met Lys Ser Asn Asn Ile Phe Leu His Glu Gly Leu
465                 470                 475                 480 
Thr Val Lys Ile Gly Asp Phe Gly Leu Ala Thr Val Lys Ser Arg Trp
                485                 490                 495     
Ser Gly Ser Gln Gln Val Glu Gln Pro Thr Gly Ser Val Leu Trp Met
            500                 505                 510         
Ala Pro Glu Val Ile Arg Met Gln Asp Asn Asn Pro Phe Ser Phe Gln
        515                 520                 525             
Ser Asp Val Tyr Ser Tyr Gly Ile Val Leu Tyr Glu Leu Met Thr Gly
    530                 535                 540                 
Glu Leu Pro Tyr Ser His Ile Asn Asn Arg Asp Gln Ile Ile Phe Met
545                 550                 555                 560 
Val Gly Arg Gly Tyr Ala Ser Pro Asp Leu Ser Lys Leu Tyr Lys Asn
                565                 570                 575     
Cys Pro Lys Ala Met Lys Arg Leu Val Ala Asp Cys Val Lys Lys Val
            580                 585                 590         
Lys Glu Glu Arg Pro Leu Phe Pro Gln Ile Leu Ser Ser Ile Glu Leu
        595                 600                 605             
Leu Gln His Ser Leu Pro Lys Ile Asn Arg Ser Ala Ser Glu Pro Ser
    610                 615                 620                 
Leu His Arg Ala Ala His Thr Glu Asp Ile Asn Ala Cys Thr Leu Thr
625                 630                 635                 640 
Thr Ser Pro Arg Leu Pro Val Phe
                645             


<210> 491
<211> 184
<212> PRT
<213> Homo sapiens

<400> 491
Met Arg Glu Tyr Lys Leu Val Val Leu Gly Ser Gly Gly Val Gly Lys
 1               5                  10                  15      
Ser Ala Leu Thr Val Gln Phe Val Gln Gly Ile Phe Val Glu Lys Tyr
            20                  25                  30          
Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Glu Val Asp Cys
        35                  40                  45              
Gln Gln Cys Met Leu Glu Ile Leu Asp Thr Ala Gly Thr Glu Gln Phe
    50                  55                  60                  
Thr Ala Met Arg Asp Leu Tyr Met Lys Asn Gly Gln Gly Phe Ala Leu
65                  70                  75                  80  
Val Tyr Ser Ile Thr Ala Gln Ser Thr Phe Asn Asp Leu Gln Asp Leu
                85                  90                  95      
Arg Glu Gln Ile Leu Arg Val Lys Asp Thr Glu Asp Val Pro Met Ile
            100                 105                 110         
Leu Val Gly Asn Lys Cys Asp Leu Glu Asp Glu Arg Val Val Gly Lys
        115                 120                 125             
Glu Gln Gly Gln Asn Leu Ala Arg Gln Trp Cys Asn Cys Ala Phe Leu
    130                 135                 140                 
Glu Ser Ser Ala Lys Ser Lys Ile Asn Val Asn Glu Ile Phe Tyr Asp
145                 150                 155                 160 
Leu Val Arg Gln Ile Asn Arg Lys Thr Pro Val Glu Lys Lys Lys Pro
                165                 170                 175     
Lys Lys Lys Ser Cys Leu Leu Leu
            180                 


<210> 492
<211> 366
<212> PRT
<213> Homo sapiens

<400> 492
Met Val Lys Leu Phe Ile Gly Asn Leu Pro Arg Glu Ala Thr Glu Gln
 1               5                  10                  15      
Glu Ile Arg Ser Leu Phe Glu Gln Tyr Gly Lys Val Leu Glu Cys Asp
            20                  25                  30          
Ile Ile Lys Asn Tyr Gly Phe Val His Ile Glu Asp Lys Thr Ala Ala
        35                  40                  45              
Glu Asp Ala Ile Arg Asn Leu His His Tyr Lys Leu His Gly Val Asn
    50                  55                  60                  
Ile Asn Val Glu Ala Ser Lys Asn Lys Ser Lys Thr Ser Thr Lys Leu
65                  70                  75                  80  
His Val Gly Asn Ile Ser Pro Thr Cys Thr Asn Lys Glu Leu Arg Ala
                85                  90                  95      
Lys Phe Glu Glu Tyr Gly Pro Val Ile Glu Cys Asp Ile Val Lys Asp
            100                 105                 110         
Tyr Ala Phe Val His Met Glu Arg Ala Glu Asp Ala Val Glu Ala Ile
        115                 120                 125             
Arg Gly Leu Asp Asn Thr Glu Phe Gln Gly Lys Arg Met His Val Gln
    130                 135                 140                 
Leu Ser Thr Ser Arg Leu Arg Thr Ala Pro Gly Met Gly Asp Gln Ser
145                 150                 155                 160 
Gly Cys Tyr Arg Cys Gly Lys Glu Gly His Trp Ser Lys Glu Cys Pro
                165                 170                 175     
Ile Asp Arg Ser Gly Arg Val Ala Asp Leu Thr Glu Gln Tyr Asn Glu
            180                 185                 190         
Gln Tyr Gly Ala Val Arg Thr Pro Tyr Thr Met Ser Tyr Gly Asp Ser
        195                 200                 205             
Leu Tyr Tyr Asn Asn Ala Tyr Gly Ala Leu Asp Ala Tyr Tyr Lys Arg
    210                 215                 220                 
Cys Arg Ala Ala Arg Ser Tyr Glu Ala Val Gln Leu Gln Leu Pro Pro
225                 230                 235                 240 
Cys Ile Ile Thr Gln Ser Arg Pro Cys Pro Ser Cys His Lys Ser Arg
                245                 250                 255     
Ile Gln Pro Trp Pro Val Thr Ser Pro Pro Pro Leu Ser Ile Pro Thr
            260                 265                 270         
Ile Asp Thr Cys Cys Arg Pro Gln Glu Leu Leu Pro Gln Leu Leu Leu
        275                 280                 285             
Gln Gln Gln Pro Leu Leu Leu Leu Leu Gln Leu Pro Leu His Ile Thr
    290                 295                 300                 
Gly Gly Ile Gly Ala Pro Cys Val Ala Leu Gln Pro Gln Ser Pro Leu
305                 310                 315                 320 
Leu Glu Arg Ala Thr Val Thr Gly Met Arg Val Ser Cys Pro Lys Leu
                325                 330                 335     
Gln Gln Pro Arg Gly Ile Leu Cys Thr Thr Trp Pro Gly Met Ser Gly
            340                 345                 350         
Ser Ser Met Pro Ile Gly Arg Gly Thr Gln Pro Phe Lys Ala
        355                 360                 365     


<210> 493
<211> 211
<212> PRT
<213> Homo sapiens

<400> 493
Met Gln Ser Ala Met Phe Leu Ala Val Gln His Asp Cys Arg Pro Met
 1               5                  10                  15      
Asp Lys Ser Ala Gly Ser Gly His Lys Ser Glu Glu Lys Arg Glu Lys
            20                  25                  30          
Met Lys Arg Thr Leu Leu Lys Asp Trp Lys Thr Arg Leu Ser Tyr Phe
        35                  40                  45              
Leu Gln Asn Ser Ser Thr Pro Gly Lys Pro Lys Thr Gly Lys Lys Ser
    50                  55                  60                  
Lys Gln Gln Ala Phe Ile Lys Pro Ser Pro Glu Glu Ala Gln Leu Trp
65                  70                  75                  80  
Ser Glu Ala Phe Asp Glu Leu Leu Ala Ser Lys Tyr Gly Leu Ala Ala
                85                  90                  95      
Phe Arg Ala Phe Leu Lys Ser Glu Phe Cys Glu Glu Asn Ile Glu Phe
            100                 105                 110         
Trp Leu Ala Cys Glu Asp Phe Lys Lys Thr Lys Ser Pro Gln Lys Leu
        115                 120                 125             
Ser Ser Lys Ala Arg Lys Ile Tyr Thr Asp Phe Ile Glu Lys Glu Ala
    130                 135                 140                 
Pro Lys Glu Ile Asn Ile Asp Phe Gln Thr Lys Thr Leu Ile Ala Gln
145                 150                 155                 160 
Asn Ile Gln Glu Ala Thr Ser Gly Cys Phe Thr Thr Ala Gln Lys Arg
                165                 170                 175     
Val Tyr Ser Leu Met Glu Asn Asn Ser Tyr Pro Arg Phe Leu Glu Ser
            180                 185                 190         
Glu Phe Tyr Gln Asp Leu Cys Lys Lys Pro Gln Ile Thr Thr Glu Pro
        195                 200                 205             
His Ala Thr
    210     


<210> 494
<211> 1657
<212> PRT
<213> Homo sapiens

<400> 494
Met Ser Ala Ala Asp Glu Val Asp Gly Leu Gly Val Ala Arg Pro His
 1               5                  10                  15      
Tyr Gly Ser Val Leu Asp Asn Glu Arg Leu Thr Ala Glu Glu Met Asp
            20                  25                  30          
Glu Arg Arg Arg Gln Asn Val Ala Tyr Glu Tyr Leu Cys His Leu Glu
        35                  40                  45              
Glu Ala Lys Arg Trp Met Glu Ala Cys Leu Gly Glu Asp Leu Pro Pro
    50                  55                  60                  
Thr Thr Glu Leu Glu Glu Gly Leu Arg Asn Gly Val Tyr Leu Ala Lys
65                  70                  75                  80  
Leu Gly Asn Phe Phe Ser Pro Lys Val Val Ser Leu Lys Lys Ile Tyr
                85                  90                  95      
Asp Arg Glu Gln Thr Arg Tyr Lys Ala Thr Gly Leu His Phe Arg His
            100                 105                 110         
Thr Asp Asn Val Ile Gln Trp Leu Asn Ala Met Asp Glu Ile Gly Leu
        115                 120                 125             
Pro Lys Ile Phe Tyr Pro Glu Thr Thr Asp Ile Tyr Asp Arg Lys Asn
    130                 135                 140                 
Met Pro Arg Cys Ile Tyr Cys Ile His Ala Leu Ser Leu Tyr Leu Phe
145                 150                 155                 160 
Lys Leu Gly Leu Ala Pro Gln Ile Gln Asp Leu Tyr Gly Lys Val Asp
                165                 170                 175     
Phe Thr Glu Glu Glu Ile Asn Asn Met Lys Thr Glu Leu Glu Lys Tyr
            180                 185                 190         
Gly Ile Gln Met Pro Ala Phe Ser Lys Ile Gly Gly Ile Leu Ala Asn
        195                 200                 205             
Glu Leu Ser Val Asp Glu Ala Ala Leu His Ala Ala Val Ile Ala Ile
    210                 215                 220                 
Asn Glu Ala Ile Asp Arg Arg Ile Pro Ala Asp Thr Phe Ala Ala Leu
225                 230                 235                 240 
Lys Asn Pro Asn Ala Met Leu Val Asn Leu Glu Glu Pro Leu Ala Ser
                245                 250                 255     
Thr Tyr Gln Asp Ile Leu Tyr Gln Ala Lys Gln Asp Lys Met Thr Asn
            260                 265                 270         
Ala Lys Asn Arg Thr Glu Asn Ser Glu Arg Glu Arg Asp Val Tyr Glu
        275                 280                 285             
Glu Leu Leu Thr Gln Ala Glu Ile Gln Gly Asn Ile Asn Lys Val Asn
    290                 295                 300                 
Thr Phe Ser Ala Leu Ala Asn Ile Asp Leu Ala Leu Glu Gln Gly Asp
305                 310                 315                 320 
Ala Leu Ala Leu Phe Arg Ala Leu Gln Ser Pro Ala Leu Gly Leu Arg
                325                 330                 335     
Gly Leu Gln Gln Gln Asn Ser Asp Trp Tyr Leu Lys Gln Leu Leu Ser
            340                 345                 350         
Asp Lys Gln Gln Lys Arg Gln Ser Gly Gln Thr Asp Pro Leu Gln Lys
        355                 360                 365             
Glu Glu Leu Gln Ser Gly Val Asp Ala Ala Asn Ser Ala Ala Gln Gln
    370                 375                 380                 
Tyr Gln Arg Arg Leu Ala Ala Val Ala Leu Ile Asn Ala Ala Ile Gln
385                 390                 395                 400 
Lys Gly Val Ala Glu Lys Thr Val Leu Glu Leu Met Asn Pro Glu Ala
                405                 410                 415     
Gln Leu Pro Gln Val Tyr Pro Phe Ala Ala Asp Leu Tyr Gln Lys Glu
            420                 425                 430         
Leu Ala Thr Leu Gln Arg Gln Ser Pro Glu His Asn Leu Thr His Pro
        435                 440                 445             
Glu Leu Ser Val Ala Val Glu Met Leu Ser Ser Val Ala Leu Ile Asn
    450                 455                 460                 
Arg Ala Leu Glu Ser Gly Asp Val Asn Thr Val Trp Lys Gln Leu Ser
465                 470                 475                 480 
Ser Ser Val Thr Gly Leu Thr Asn Ile Glu Glu Glu Asn Cys Gln Arg
                485                 490                 495     
Tyr Leu Asp Glu Leu Met Lys Leu Lys Ala Gln Ala His Ala Glu Asn
            500                 505                 510         
Asn Glu Phe Ile Thr Trp Asn Asp Ile Gln Ala Cys Val Asp His Val
        515                 520                 525             
Asn Leu Val Val Gln Glu Glu His Glu Arg Ile Leu Ala Ile Gly Leu
    530                 535                 540                 
Ile Asn Glu Ala Leu Asp Glu Gly Asp Ala Gln Lys Thr Leu Gln Ala
545                 550                 555                 560 
Leu Gln Ile Pro Ala Ala Lys Leu Glu Gly Val Leu Ala Glu Val Ala
                565                 570                 575     
Gln His Tyr Gln Asp Thr Leu Ile Arg Ala Lys Arg Glu Lys Ala Gln
            580                 585                 590         
Glu Ile Gln Asp Glu Ser Ala Val Leu Trp Leu Asp Glu Ile Gln Gly
        595                 600                 605             
Gly Ile Trp Gln Ser Asn Lys Asp Thr Gln Glu Ala Gln Lys Phe Ala
    610                 615                 620                 
Leu Gly Ile Phe Ala Ile Asn Glu Ala Val Glu Ser Gly Asp Val Gly
625                 630                 635                 640 
Lys Thr Leu Ser Ala Leu Arg Ser Pro Asp Val Gly Leu Tyr Gly Val
                645                 650                 655     
Ile Pro Glu Cys Gly Glu Thr Tyr His Ser Asp Leu Ala Glu Ala Lys
            660                 665                 670         
Lys Lys Lys Leu Ala Val Gly Asp Asn Asn Ser Lys Trp Val Lys His
        675                 680                 685             
Trp Val Lys Gly Gly Tyr Tyr Tyr Tyr His Asn Leu Glu Thr Gln Glu
    690                 695                 700                 
Gly Gly Trp Asp Glu Pro Pro Asn Phe Val Gln Asn Ser Met Gln Leu
705                 710                 715                 720 
Ser Arg Glu Glu Ile Gln Ser Ser Ile Ser Gly Val Thr Ala Ala Tyr
                725                 730                 735     
Asn Arg Glu Gln Leu Trp Leu Ala Asn Glu Gly Leu Ile Thr Arg Leu
            740                 745                 750         
Gln Ala Arg Cys Arg Gly Tyr Leu Val Arg Gln Glu Phe Arg Ser Arg
        755                 760                 765             
Met Asn Phe Leu Lys Lys Gln Ile Pro Ala Ile Thr Cys Ile Gln Ser
    770                 775                 780                 
Gln Trp Arg Gly Tyr Lys Gln Lys Lys Ala Tyr Gln Asp Arg Leu Ala
785                 790                 795                 800 
Tyr Leu Arg Ser His Lys Asp Glu Val Val Lys Ile Gln Ser Leu Ala
                805                 810                 815     
Arg Met His Gln Ala Arg Lys Arg Tyr Arg Asp Arg Leu Gln Tyr Phe
            820                 825                 830         
Arg Asp His Ile Asn Asp Ile Ile Lys Ile Gln Ala Phe Ile Arg Ala
        835                 840                 845             
Asn Lys Ala Arg Asp Asp Tyr Lys Thr Leu Ile Asn Ala Glu Asp Pro
    850                 855                 860                 
Pro Met Val Val Val Arg Lys Phe Val His Leu Leu Asp Gln Ser Asp
865                 870                 875                 880 
Gln Asp Phe Gln Glu Glu Leu Asp Leu Met Lys Met Arg Glu Glu Val
                885                 890                 895     
Ile Thr Leu Ile Arg Ser Asn Gln Gln Leu Glu Asn Asp Leu Asn Leu
            900                 905                 910         
Met Asp Ile Lys Ile Gly Leu Leu Val Lys Asn Lys Ile Thr Leu Gln
        915                 920                 925             
Asp Val Val Ser His Ser Lys Lys Leu Thr Lys Lys Asn Lys Glu Gln
    930                 935                 940                 
Leu Ser Asp Met Met Met Ile Asn Lys Gln Lys Gly Gly Leu Lys Ala
945                 950                 955                 960 
Leu Ser Lys Glu Lys Arg Glu Lys Leu Glu Ala Tyr Gln His Leu Phe
                965                 970                 975     
Tyr Leu Leu Gln Thr Asn Pro Thr Tyr Leu Ala Lys Leu Ile Phe Gln
            980                 985                 990         
Met Pro Gln Asn Lys Ser Thr Lys Phe Met Asp Ser Val Ile Phe Thr
        995                 1000                1005            
Leu Tyr Asn Tyr Ala Ser Asn Gln Arg Glu Glu Tyr Leu Leu Leu Arg
    1010                1015                1020                
Leu Phe Lys Thr Ala Leu Gln Glu Glu Ile Lys Ser Lys Val Asp Gln
1025                1030                1035                1040
Ile Gln Glu Ile Val Thr Gly Asn Pro Thr Val Ile Lys Met Val Val
                1045                1050                1055    
Ser Phe Asn Arg Gly Ala Arg Gly Gln Asn Ala Leu Arg Gln Ile Leu
            1060                1065                1070        
Ala Pro Val Val Lys Glu Ile Met Asp Asp Lys Ser Leu Asn Ile Lys
        1075                1080                1085            
Thr Asp Pro Val Asp Ile Tyr Lys Ser Trp Val Asn Gln Met Glu Ser
    1090                1095                1100                
Gln Thr Gly Glu Ala Ser Lys Leu Pro Tyr Asp Val Thr Pro Glu Gln
1105                1110                1115                1120
Ala Leu Ala His Glu Glu Val Lys Thr Arg Leu Asp Ser Ser Ile Arg
                1125                1130                1135    
Asn Met Arg Ala Val Thr Asp Lys Phe Leu Ser Ala Ile Val Ser Ser
            1140                1145                1150        
Val Asp Lys Ile Pro Tyr Gly Met Arg Phe Ile Ala Lys Val Leu Lys
        1155                1160                1165            
Asp Ser Leu His Glu Lys Phe Pro Asp Ala Gly Glu Asp Glu Leu Leu
    1170                1175                1180                
Lys Ile Ile Gly Asn Leu Leu Tyr Tyr Arg Tyr Met Asn Pro Ala Ile
1185                1190                1195                1200
Val Ala Pro Asp Ala Phe Asp Ile Ile Asp Leu Ser Ala Gly Gly Gln
                1205                1210                1215    
Leu Thr Thr Asp Gln Arg Arg Asn Leu Gly Ser Ile Ala Lys Met Leu
            1220                1225                1230        
Gln His Ala Ala Ser Asn Lys Met Phe Leu Gly Asp Asn Ala His Leu
        1235                1240                1245            
Ser Ile Ile Asn Glu Tyr Leu Ser Gln Ser Tyr Gln Lys Phe Arg Arg
    1250                1255                1260                
Phe Phe Gln Thr Ala Cys Asp Val Pro Glu Leu Gln Asp Lys Phe Asn
1265                1270                1275                1280
Val Asp Glu Tyr Ser Asp Leu Val Thr Leu Thr Lys Pro Val Ile Tyr
                1285                1290                1295    
Ile Ser Ile Gly Glu Ile Ile Asn Thr His Thr Leu Leu Leu Asp His
            1300                1305                1310        
Gln Asp Ala Ile Ala Pro Glu His Asn Asp Pro Ile His Glu Leu Leu
        1315                1320                1325            
Asp Asp Leu Gly Glu Val Pro Thr Ile Glu Ser Leu Ile Gly Glu Ser
    1330                1335                1340                
Ser Gly Asn Leu Asn Asp Pro Asn Lys Glu Ala Leu Ala Lys Thr Glu
1345                1350                1355                1360
Val Ser Leu Thr Leu Thr Asn Lys Phe Asp Val Pro Gly Asp Glu Asn
                1365                1370                1375    
Ala Glu Met Asp Ala Arg Thr Ile Leu Leu Asn Thr Lys Arg Leu Ile
            1380                1385                1390        
Val Asp Val Ile Arg Phe Gln Pro Gly Glu Thr Leu Thr Glu Ile Leu
        1395                1400                1405            
Glu Thr Pro Ala Thr Ser Glu Gln Glu Ala Glu His Gln Arg Ala Met
    1410                1415                1420                
Gln Arg Arg Ala Ile Arg Asp Ala Lys Thr Pro Asp Lys Met Lys Lys
1425                1430                1435                1440
Ser Lys Ser Val Lys Glu Asp Ser Asn Leu Thr Leu Gln Glu Lys Lys
                1445                1450                1455    
Glu Lys Ile Gln Thr Gly Leu Lys Lys Leu Thr Glu Leu Gly Thr Val
            1460                1465                1470        
Asp Pro Lys Asn Lys Tyr Gln Glu Leu Ile Asn Asp Ile Ala Arg Asp
        1475                1480                1485            
Ile Arg Asn Gln Arg Arg Tyr Arg Gln Arg Arg Lys Ala Glu Leu Val
    1490                1495                1500                
Lys Leu Gln Gln Thr Tyr Ala Ala Leu Asn Ser Lys Ala Thr Phe Tyr
1505                1510                1515                1520
Gly Glu Gln Val Asp Tyr Tyr Lys Ser Tyr Ile Lys Thr Cys Leu Asp
                1525                1530                1535    
Asn Leu Ala Ser Lys Gly Lys Val Ser Lys Lys Pro Arg Glu Met Lys
            1540                1545                1550        
Gly Lys Lys Ser Lys Lys Ile Ser Leu Lys Tyr Thr Ala Ala Arg Leu
        1555                1560                1565            
His Glu Lys Gly Val Leu Leu Glu Ile Glu Asp Leu Gln Val Asn Gln
    1570                1575                1580                
Phe Lys Asn Val Ile Phe Glu Ile Ser Pro Thr Glu Glu Val Gly Asp
1585                1590                1595                1600
Phe Glu Val Lys Ala Lys Phe Met Gly Val Gln Met Glu Thr Phe Met
                1605                1610                1615    
Leu His Tyr Gln Asp Leu Leu Gln Leu Gln Tyr Glu Gly Val Ala Val
            1620                1625                1630        
Met Lys Leu Phe Asp Arg Ala Lys Val Asn Val Asn Leu Leu Ile Phe
        1635                1640                1645            
Leu Leu Asn Lys Lys Phe Tyr Gly Lys
    1650                1655        


<210> 495
<211> 1287
<212> PRT
<213> Homo sapiens

<400> 495
Met Glu Pro Ile Tyr Pro Phe Ala Arg Pro Gln Met Asn Thr Arg Phe
 1               5                  10                  15      
Pro Ser Ser Arg Met Val Pro Phe His Phe Pro Pro Ser Lys Cys Ala
            20                  25                  30          
Leu Trp Asn Pro Thr Pro Thr Gly Asp Phe Ile Tyr Leu His Leu Ser
        35                  40                  45              
Tyr Tyr Arg Asn Pro Lys Leu Val Val Thr Glu Lys Thr Ile Arg Leu
    50                  55                  60                  
Ala Tyr Arg His Ala Asn Glu Asn Lys Lys Asn Ser Ser Cys Phe Leu
65                  70                  75                  80  
Leu Gly Ser Leu Thr Ala Asp Glu Asp Glu Glu Gly Val Thr Leu Thr
                85                  90                  95      
Val Asp Arg Phe Asp Pro Gly Arg Glu Val Pro Glu Cys Leu Glu Ile
            100                 105                 110         
Thr Pro Thr Ala Ser Leu Pro Gly Asp Phe Leu Ile Pro Cys Lys Val
        115                 120                 125             
His Thr Gln Glu Leu Cys Ser Arg Glu Met Ile Val His Ser Val Asp
    130                 135                 140                 
Asp Phe Ser Ser Ala Leu Lys Ala Leu Gln Cys His Ile Cys Ser Lys
145                 150                 155                 160 
Asp Ser Leu Asp Cys Gly Lys Leu Leu Ser Leu Arg Val His Ile Thr
                165                 170                 175     
Ser Arg Glu Ser Leu Asp Ser Val Glu Phe Asp Leu His Trp Ala Ala
            180                 185                 190         
Val Thr Leu Ala Asn Asn Phe Lys Cys Thr Pro Val Lys Pro Ile Pro
        195                 200                 205             
Ile Ile Pro Thr Ala Leu Ala Arg Asn Leu Ser Ser Asn Leu Asn Ile
    210                 215                 220                 
Ser Gln Val Gln Gly Thr Tyr Lys Tyr Gly Tyr Leu Thr Met Asp Glu
225                 230                 235                 240 
Thr Arg Lys Leu Leu Leu Leu Leu Glu Ser Asp Pro Lys Val Tyr Ser
                245                 250                 255     
Leu Pro Leu Val Gly Ile Trp Leu Ser Gly Ile Thr His Ile Tyr Ser
            260                 265                 270         
Pro Gln Val Trp Ala Cys Cys Leu Arg Tyr Ile Phe Asn Ser Ser Val
        275                 280                 285             
Gln Glu Arg Val Phe Ser Glu Ser Gly Asn Phe Ile Ile Val Leu Tyr
    290                 295                 300                 
Ser Met Thr His Lys Glu Pro Glu Phe Tyr Glu Cys Phe Pro Cys Asp
305                 310                 315                 320 
Gly Lys Ile Pro Asp Phe Arg Phe Gln Leu Leu Thr Ser Lys Glu Thr
                325                 330                 335     
Leu His Leu Phe Lys Asn Val Glu Pro Pro Asp Lys Asn Pro Ile Arg
            340                 345                 350         
Cys Glu Leu Ser Ala Glu Ser Gln Asn Ala Glu Thr Glu Phe Phe Ser
        355                 360                 365             
Lys Ala Ser Lys Asn Phe Ser Ile Lys Arg Ser Ser Gln Lys Leu Ser
    370                 375                 380                 
Ser Gly Lys Met Pro Ile His Asp His Asp Ser Gly Val Glu Asp Glu
385                 390                 395                 400 
Asp Phe Ser Pro Arg Pro Ile Pro Ser Pro His Pro Val Ser Gln Lys
                405                 410                 415     
Ile Ser Lys Ile Gln Pro Ser Val Pro Glu Leu Ser Leu Val Leu Asp
            420                 425                 430         
Gly Asn Phe Ile Glu Ser Asn Pro Leu Pro Thr Pro Leu Glu Met Val
        435                 440                 445             
Asn Asn Glu Asn Pro Pro Leu Ile Asn His Leu Glu His Leu Lys Pro
    450                 455                 460                 
Leu Gln Pro Gln Leu Tyr Asp Glu Lys His Ser Pro Glu Val Glu Ala
465                 470                 475                 480 
Gly Glu Pro Ser Leu Arg Gly Ile Pro Asn Gln Leu Asn Gln Asp Lys
                485                 490                 495     
Pro Ala Leu Leu Arg His Cys Lys Val Arg Gln Pro Pro Ala Tyr Lys
            500                 505                 510         
Lys Gly Asn Pro His Thr Arg Asn Ser Ile Lys Pro Ser Ser His Asn
        515                 520                 525             
Gly Pro Ser His Asp Ile Phe Glu Lys Leu Gln Thr Val Ser Ala Gly
    530                 535                 540                 
Asn Val Gln Asn Glu Glu Tyr Pro Ile Arg Pro Ser Thr Leu Asn Ser
545                 550                 555                 560 
Arg Gln Ser Ser Leu Ala Pro Gln Ser Gln Pro His Asp Phe Val Phe
                565                 570                 575     
Ser Pro His Asn Ser Gly Arg Pro Met Glu Leu Gln Ile Pro Thr Pro
            580                 585                 590         
Pro Leu Pro Ser Tyr Cys Ser Thr Asn Val Cys Arg Cys Cys Gln His
        595                 600                 605             
His Ser His Ile Gln Tyr Ser Pro Leu Asn Ser Trp Gln Gly Ala Asn
    610                 615                 620                 
Thr Val Gly Ser Ile Gln Asp Val Gln Ser Glu Ala Leu Gln Lys His
625                 630                 635                 640 
Ser Leu Phe His Pro Ser Gly Cys Pro Ala Leu Tyr Cys Asn Ala Phe
                645                 650                 655     
Cys Ser Ser Ser Ser Pro Ile Ala Leu Arg Pro Gln Gly Asp Met Gly
            660                 665                 670         
Ser Cys Ser Pro His Ser Asn Ile Glu Pro Ser Pro Val Ala Arg Pro
        675                 680                 685             
Pro Ser His Met Asp Leu Cys Asn Pro Gln Pro Cys Thr Val Cys Met
    690                 695                 700                 
His Thr Pro Lys Thr Glu Ser Asp Asn Gly Met Met Gly Leu Ser Pro
705                 710                 715                 720 
Asp Ala Tyr Arg Phe Leu Thr Glu Gln Asp Arg Gln Leu Arg Leu Leu
                725                 730                 735     
Gln Ala Gln Ile Gln Arg Leu Leu Glu Ala Gln Ser Leu Met Pro Cys
            740                 745                 750         
Ser Pro Lys Thr Thr Ala Val Glu Asp Thr Val Gln Ala Gly Arg Gln
        755                 760                 765             
Met Glu Leu Val Ser Val Glu Ala Gln Ser Ser Pro Gly Leu His Met
    770                 775                 780                 
Arg Lys Gly Val Ser Ile Ala Val Ser Thr Gly Ala Ser Leu Phe Trp
785                 790                 795                 800 
Asn Ala Ala Gly Glu Asp Gln Glu Pro Asp Ser Gln Met Lys Gln Asp
                805                 810                 815     
Asp Thr Lys Ile Ser Ser Glu Asp Met Asn Phe Ser Val Asp Ile Asn
            820                 825                 830         
Asn Glu Val Thr Ser Leu Pro Gly Ser Ala Ser Ser Leu Lys Ala Val
        835                 840                 845             
Asp Ile Pro Ser Phe Glu Glu Ser Asn Ile Ala Val Glu Glu Glu Phe
    850                 855                 860                 
Asn Gln Pro Leu Ser Val Ser Asn Ser Ser Leu Val Val Arg Lys Glu
865                 870                 875                 880 
Pro Asp Val Pro Val Phe Phe Pro Ser Gly Gln Leu Ala Glu Ser Val
                885                 890                 895     
Ser Met Cys Leu Gln Thr Gly Pro Thr Gly Gly Ala Ser Asn Asn Ser
            900                 905                 910         
Glu Thr Ser Glu Glu Pro Lys Ile Glu His Val Met Gln Pro Leu Leu
        915                 920                 925             
His Gln Pro Ser Asp Asn Gln Lys Ile Tyr Gln Asp Leu Leu Gly Gln
    930                 935                 940                 
Val Asn His Leu Leu Asn Ser Ser Ser Lys Glu Thr Glu Gln Pro Ser
945                 950                 955                 960 
Thr Lys Ala Val Ile Ile Ser His Glu Cys Thr Arg Thr Gln Asn Val
                965                 970                 975     
Tyr His Thr Lys Lys Lys Thr His His Ser Arg Leu Val Asp Lys Asp
            980                 985                 990         
Cys Val Leu Asn Ala Thr Leu Lys Gln Leu Arg Ser Leu Gly Val Lys
        995                 1000                1005            
Ile Asp Ser Pro Thr Lys Val Lys Lys Asn Ala His Asn Val Asp His
    1010                1015                1020                
Ala Ser Val Leu Ala Cys Ile Ser Pro Glu Ala Val Ile Ser Gly Leu
1025                1030                1035                1040
Asn Cys Met Ser Phe Ala Asn Val Gly Met Ser Gly Leu Ser Pro Asn
                1045                1050                1055    
Gly Val Asp Leu Ser Met Glu Ala Asn Ala Ile Ala Leu Lys Tyr Leu
            1060                1065                1070        
Asn Glu Asn Gln Leu Ser Gln Leu Ser Val Thr Arg Ser Asn Gln Asn
        1075                1080                1085            
Asn Cys Asp Pro Phe Ser Leu Leu His Ile Asn Thr Asp Arg Ser Thr
    1090                1095                1100                
Val Gly Leu Ser Leu Ile Ser Pro Asn Asn Met Ser Phe Ala Thr Lys
1105                1110                1115                1120
Lys Tyr Met Lys Arg Tyr Gly Leu Leu Gln Ser Ser Asp Asn Ser Glu
                1125                1130                1135    
Asp Glu Glu Glu Pro Pro Asp Asn Ala Asp Ser Lys Ser Glu Tyr Leu
            1140                1145                1150        
Leu Asn Gln Asn Leu Arg Ser Ile Pro Glu Gln Leu Gly Gly Gln Lys
        1155                1160                1165            
Glu Pro Ser Lys Asn Asp His Glu Ile Ile Asn Cys Ser Asn Cys Glu
    1170                1175                1180                
Ser Val Gly Thr Asn Ala Asp Thr Pro Val Leu Arg Asn Ile Thr Asn
1185                1190                1195                1200
Glu Val Leu Gln Thr Lys Ala Lys Gln Gln Leu Thr Glu Lys Pro Ala
                1205                1210                1215    
Phe Leu Val Lys Asn Leu Lys Pro Ser Pro Ala Val Asn Leu Arg Thr
            1220                1225                1230        
Gly Lys Ala Glu Phe Thr Gln His Pro Glu Lys Glu Asn Glu Gly Asp
        1235                1240                1245            
Ile Thr Ile Phe Pro Glu Ser Leu Gln Pro Ser Glu Thr Leu Lys Gln
    1250                1255                1260                
Met Asn Ser Met Asn Ser Val Gly Thr Phe Leu Asp Val Lys Arg Leu
1265                1270                1275                1280
Arg Gln Leu Pro Lys Leu Phe
                1285        


<210> 496
<211> 1212
<212> PRT
<213> Homo sapiens

<400> 496
Met Glu Pro Arg Pro Thr Ala Pro Ser Ser Gly Ala Pro Gly Leu Ala
 1               5                  10                  15      
Gly Val Gly Glu Thr Pro Ser Ala Ala Ala Leu Ala Ala Ala Arg Val
            20                  25                  30          
Glu Leu Pro Gly Thr Ala Val Pro Ser Val Pro Glu Asp Ala Ala Pro
        35                  40                  45              
Ala Ser Arg Asp Gly Gly Gly Val Arg Asp Glu Gly Pro Ala Ala Ala
    50                  55                  60                  
Gly Asp Gly Leu Gly Arg Pro Leu Gly Pro Thr Pro Ser Gln Ser Arg
65                  70                  75                  80  
Phe Gln Val Asp Leu Val Ser Glu Asn Ala Gly Arg Ala Ala Ala Ala
                85                  90                  95      
Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Ala Gly Ala Gly
            100                 105                 110         
Ala Lys Gln Thr Pro Ala Asp Gly Glu Ala Ser Gly Glu Ser Glu Pro
        115                 120                 125             
Ala Lys Gly Ser Glu Glu Ala Lys Gly Arg Phe Arg Val Asn Phe Val
    130                 135                 140                 
Asp Pro Ala Ala Ser Ser Ser Ala Glu Asp Ser Leu Ser Asp Ala Ala
145                 150                 155                 160 
Gly Val Gly Val Asp Gly Pro Asn Val Ser Phe Gln Asn Gly Gly Asp
                165                 170                 175     
Thr Val Leu Ser Glu Gly Ser Ser Leu His Ser Gly Gly Gly Gly Gly
            180                 185                 190         
Ser Gly His His Gln His Tyr Tyr Tyr Asp Thr His Thr Asn Thr Tyr
        195                 200                 205             
Tyr Leu Arg Thr Phe Gly His Asn Thr Met Asp Ala Val Pro Arg Ile
    210                 215                 220                 
Asp His Tyr Arg His Thr Ala Ala Gln Leu Gly Glu Lys Leu Leu Arg
225                 230                 235                 240 
Pro Ser Leu Ala Glu Leu His Asp Glu Leu Glu Lys Glu Pro Phe Glu
                245                 250                 255     
Asp Gly Phe Ala Asn Gly Glu Glu Ser Thr Pro Thr Arg Asp Ala Val
            260                 265                 270         
Val Thr Tyr Thr Ala Glu Ser Lys Gly Val Val Lys Phe Gly Trp Ile
        275                 280                 285             
Lys Gly Val Leu Val Arg Cys Met Leu Asn Ile Trp Gly Val Met Leu
    290                 295                 300                 
Phe Ile Arg Leu Ser Trp Ile Val Gly Gln Ala Gly Ile Gly Leu Ser
305                 310                 315                 320 
Val Leu Val Ile Met Met Ala Thr Val Val Thr Thr Ile Thr Gly Leu
                325                 330                 335     
Ser Thr Ser Ala Ile Ala Thr Asn Gly Phe Val Arg Gly Gly Gly Ala
            340                 345                 350         
Tyr Tyr Leu Ile Ser Arg Ser Leu Gly Pro Glu Phe Gly Gly Ala Ile
        355                 360                 365             
Gly Leu Ile Phe Ala Phe Ala Asn Ala Val Ala Val Ala Met Tyr Val
    370                 375                 380                 
Val Gly Phe Ala Glu Thr Val Val Glu Leu Leu Lys Glu His Ser Ile
385                 390                 395                 400 
Leu Met Ile Asp Glu Ile Asn Asp Ile Arg Ile Ile Gly Ala Ile Thr
                405                 410                 415     
Val Val Ile Leu Leu Gly Ile Ser Val Ala Gly Met Glu Trp Glu Ala
            420                 425                 430         
Lys Ala Gln Ile Val Leu Leu Val Ile Leu Leu Leu Ala Ile Gly Asp
        435                 440                 445             
Phe Val Ile Gly Thr Phe Ile Pro Leu Glu Ser Lys Lys Pro Lys Gly
    450                 455                 460                 
Phe Phe Gly Tyr Lys Ser Glu Ile Phe Asn Glu Asn Phe Gly Pro Asp
465                 470                 475                 480 
Phe Arg Glu Glu Glu Thr Phe Phe Ser Val Phe Ala Ile Phe Phe Pro
                485                 490                 495     
Ala Ala Thr Gly Ile Leu Ala Gly Ala Asn Ile Ser Gly Asp Leu Ala
            500                 505                 510         
Asp Pro Gln Ser Ala Ile Pro Lys Gly Thr Leu Leu Ala Ile Leu Ile
        515                 520                 525             
Thr Thr Leu Val Tyr Val Gly Ile Ala Val Ser Val Gly Ser Cys Val
    530                 535                 540                 
Val Arg Asp Ala Thr Gly Asn Val Asn Asp Thr Ile Val Thr Glu Leu
545                 550                 555                 560 
Thr Asn Cys Thr Ser Ala Ala Cys Lys Leu Asn Phe Asp Phe Ser Ser
                565                 570                 575     
Cys Glu Ser Ser Pro Cys Ser Tyr Gly Leu Met Asn Asn Phe Gln Val
            580                 585                 590         
Met Ser Met Val Ser Gly Phe Thr Pro Leu Ile Ser Ala Gly Ile Phe
        595                 600                 605             
Ser Ala Thr Leu Ser Ser Ala Leu Ala Ser Leu Val Ser Ala Pro Lys
    610                 615                 620                 
Ile Phe Gln Ala Leu Cys Lys Asp Asn Ile Tyr Pro Ala Phe Gln Met
625                 630                 635                 640 
Phe Ala Lys Gly Tyr Gly Lys Asn Asn Glu Pro Leu Arg Gly Tyr Ile
                645                 650                 655     
Leu Thr Phe Leu Ile Ala Leu Gly Phe Ile Leu Ile Ala Glu Leu Asn
            660                 665                 670         
Val Ile Ala Pro Ile Ile Ser Asn Phe Phe Leu Ala Ser Tyr Ala Leu
        675                 680                 685             
Ile Asn Phe Ser Val Phe His Ala Ser Leu Ala Lys Ser Pro Gly Trp
    690                 695                 700                 
Arg Pro Ala Phe Lys Tyr Tyr Asn Met Trp Ile Ser Leu Leu Gly Ala
705                 710                 715                 720 
Ile Leu Cys Cys Ile Val Met Phe Val Ile Asn Trp Trp Ala Ala Leu
                725                 730                 735     
Leu Thr Tyr Val Ile Val Leu Gly Leu Tyr Ile Tyr Val Thr Tyr Lys
            740                 745                 750         
Lys Pro Asp Val Asn Trp Gly Ser Ser Thr Gln Ala Leu Thr Tyr Leu
        755                 760                 765             
Asn Ala Leu Gln His Ser Ile Arg Leu Ser Gly Val Glu Asp His Val
    770                 775                 780                 
Lys Asn Phe Arg Pro Gln Cys Leu Val Met Thr Gly Ala Pro Asn Ser
785                 790                 795                 800 
Arg Pro Ala Leu Leu His Leu Val His Asp Phe Thr Lys Asn Val Gly
                805                 810                 815     
Leu Met Ile Cys Gly His Val His Met Gly Pro Arg Arg Gln Ala Met
            820                 825                 830         
Lys Glu Met Ser Ile Asp Gln Ala Lys Tyr Gln Arg Trp Leu Ile Lys
        835                 840                 845             
Asn Lys Met Lys Ala Phe Tyr Ala Pro Val His Ala Asp Asp Leu Arg
    850                 855                 860                 
Glu Gly Ala Gln Tyr Leu Met Gln Ala Ala Gly Leu Gly Arg Met Lys
865                 870                 875                 880 
Pro Asn Thr Leu Val Leu Gly Phe Lys Lys Asp Trp Leu Gln Ala Asp
                885                 890                 895     
Met Arg Asp Val Asp Met Tyr Ile Asn Leu Phe His Asp Ala Phe Asp
            900                 905                 910         
Ile Gln Tyr Gly Val Val Val Ile Arg Leu Lys Glu Gly Leu Asp Ile
        915                 920                 925             
Ser His Leu Gln Gly Gln Glu Glu Leu Leu Ser Ser Gln Glu Lys Ser
    930                 935                 940                 
Pro Gly Thr Lys Asp Val Val Val Ser Val Glu Tyr Ser Lys Lys Ser
945                 950                 955                 960 
Asp Leu Asp Thr Ser Lys Pro Leu Ser Glu Lys Pro Ile Thr His Lys
                965                 970                 975     
Val Glu Glu Glu Asp Gly Lys Thr Ala Thr Gln Pro Leu Leu Lys Lys
            980                 985                 990         
Glu Ser Lys Gly Pro Ile Val Pro Leu Asn Val Ala Asp Gln Lys Leu
        995                 1000                1005            
Leu Glu Ala Ser Thr Gln Phe Gln Lys Lys Gln Gly Lys Asn Thr Ile
    1010                1015                1020                
Asp Val Trp Trp Leu Phe Asp Asp Gly Gly Leu Thr Leu Leu Ile Pro
1025                1030                1035                1040
Tyr Leu Leu Thr Thr Lys Lys Lys Trp Lys Asp Cys Lys Ile Arg Val
                1045                1050                1055    
Phe Ile Gly Gly Lys Ile Asn Arg Ile Asp His Asp Arg Arg Ala Met
            1060                1065                1070        
Ala Thr Leu Leu Ser Lys Phe Arg Ile Asp Phe Ser Asp Ile Met Val
        1075                1080                1085            
Leu Gly Asp Ile Asn Thr Lys Pro Lys Lys Glu Asn Ile Ile Ala Phe
    1090                1095                1100                
Glu Glu Ile Ile Glu Pro Tyr Arg Leu His Glu Asp Asp Lys Glu Gln
1105                1110                1115                1120
Asp Ile Ala Asp Lys Met Lys Glu Asp Glu Pro Trp Arg Ile Thr Asp
                1125                1130                1135    
Asn Glu Leu Glu Leu Tyr Lys Thr Lys Thr Tyr Arg Gln Ile Arg Leu
            1140                1145                1150        
Asn Glu Leu Leu Lys Glu His Ser Ser Thr Ala Asn Ile Ile Val Met
        1155                1160                1165            
Ser Leu Pro Val Ala Arg Lys Gly Ala Val Ser Ser Ala Leu Tyr Met
    1170                1175                1180                
Ala Trp Leu Glu Ala Leu Ser Lys Asp Leu Pro Pro Ile Leu Leu Val
1185                1190                1195                1200
Arg Gly Asn His Gln Ser Val Leu Thr Phe Tyr Ser
                1205                1210        


<210> 497
<211> 1030
<212> PRT
<213> Homo sapiens

<400> 497
Met Ala Glu Leu Pro Thr Thr Glu Thr Pro Gly Asp Ala Thr Leu Cys
 1               5                  10                  15      
Ser Gly Arg Phe Thr Ile Ser Thr Leu Leu Ser Ser Asp Glu Pro Ser
            20                  25                  30          
Pro Pro Ala Ala Tyr Asp Ser Ser His Pro Ser His Leu Thr His Ser
        35                  40                  45              
Ser Thr Phe Cys Met Arg Thr Phe Gly Tyr Asn Thr Ile Asp Val Val
    50                  55                  60                  
Pro Thr Tyr Glu His Tyr Ala Asn Ser Thr Gln Pro Gly Glu Pro Arg
65                  70                  75                  80  
Lys Val Arg Pro Thr Leu Ala Asp Leu His Ser Phe Leu Lys Gln Glu
                85                  90                  95      
Gly Arg His Leu His Ala Leu Ala Phe Asp Ser Arg Pro Ser His Glu
            100                 105                 110         
Met Thr Asp Gly Leu Val Glu Gly Glu Ala Gly Thr Ser Ser Glu Lys
        115                 120                 125             
Asn Pro Glu Glu Pro Val Arg Phe Gly Trp Val Lys Gly Val Met Ile
    130                 135                 140                 
Arg Cys Met Leu Asn Ile Trp Gly Val Ile Leu Tyr Leu Arg Leu Pro
145                 150                 155                 160 
Trp Ile Thr Ala Gln Ala Gly Ile Val Leu Thr Trp Ile Ile Ile Leu
                165                 170                 175     
Leu Ser Val Thr Val Thr Ser Ile Thr Gly Leu Ser Ile Ser Ala Ile
            180                 185                 190         
Ser Thr Asn Gly Lys Val Lys Ser Gly Gly Thr Tyr Phe Leu Ile Ser
        195                 200                 205             
Arg Ser Leu Gly Pro Glu Leu Gly Gly Ser Ile Gly Leu Ile Phe Ala
    210                 215                 220                 
Phe Ala Asn Ala Val Gly Val Ala Met His Thr Val Gly Phe Ala Glu
225                 230                 235                 240 
Thr Val Arg Asp Leu Leu Gln Glu Tyr Gly Ala Pro Ile Val Asp Pro
                245                 250                 255     
Ile Asn Asp Ile Arg Ile Ile Gly Val Val Ser Val Thr Val Leu Leu
            260                 265                 270         
Ala Ile Ser Leu Ala Gly Met Glu Trp Glu Ser Lys Ala Gln Val Leu
        275                 280                 285             
Phe Phe Leu Val Ile Met Val Ser Phe Ala Asn Tyr Leu Val Gly Thr
    290                 295                 300                 
Leu Ile Pro Pro Ser Glu Asp Lys Ala Ser Lys Gly Phe Phe Ser Tyr
305                 310                 315                 320 
Arg Ala Asp Ile Phe Val Gln Asn Leu Val Pro Asp Trp Arg Gly Pro
                325                 330                 335     
Asp Gly Thr Phe Phe Gly Met Phe Ser Ile Phe Phe Pro Ser Ala Thr
            340                 345                 350         
Gly Ile Leu Ala Gly Ala Asn Ile Ser Gly Asp Leu Lys Asp Pro Ala
        355                 360                 365             
Ile Ala Ile Pro Lys Gly Thr Leu Met Ala Ile Phe Trp Thr Thr Ile
    370                 375                 380                 
Ser Tyr Leu Ala Ile Ser Ala Thr Ile Gly Ser Cys Val Val Arg Asp
385                 390                 395                 400 
Ala Ser Gly Val Leu Asn Asp Thr Val Thr Pro Gly Trp Gly Ala Cys
                405                 410                 415     
Glu Gly Leu Ala Cys Ser Tyr Gly Trp Asn Phe Thr Glu Cys Thr Gln
            420                 425                 430         
Gln His Ser Cys His Tyr Gly Leu Ile Asn Tyr Tyr Gln Thr Met Ser
        435                 440                 445             
Met Val Ser Gly Phe Ala Pro Leu Ile Thr Ala Gly Ile Phe Gly Ala
    450                 455                 460                 
Thr Leu Ser Ser Ala Leu Ala Cys Leu Val Ser Ala Ala Lys Val Phe
465                 470                 475                 480 
Gln Cys Leu Cys Glu Asp Gln Leu Tyr Pro Leu Ile Gly Phe Phe Gly
                485                 490                 495     
Lys Gly Tyr Gly Lys Asn Lys Glu Pro Val Arg Gly Tyr Leu Leu Ala
            500                 505                 510         
Tyr Ala Ile Ala Val Ala Phe Ile Ile Ile Ala Glu Leu Asn Thr Ile
        515                 520                 525             
Ala Pro Ile Ile Ser Asn Phe Phe Leu Cys Ser Tyr Ala Leu Ile Asn
    530                 535                 540                 
Phe Ser Cys Phe His Ala Ser Ile Thr Asn Ser Pro Gly Trp Arg Pro
545                 550                 555                 560 
Ser Phe Gln Tyr Tyr Asn Lys Trp Ala Ala Leu Phe Gly Ala Ile Ile
                565                 570                 575     
Ser Val Val Ile Met Phe Leu Leu Thr Trp Trp Ala Ala Leu Ile Ala
            580                 585                 590         
Ile Gly Val Val Leu Phe Leu Leu Leu Tyr Val Ile Tyr Lys Lys Pro
        595                 600                 605             
Glu Val Asn Trp Gly Ser Ser Val Gln Ala Gly Ser Tyr Asn Leu Ala
    610                 615                 620                 
Leu Ser Tyr Ser Val Gly Leu Asn Glu Val Glu Asp His Ile Lys Asn
625                 630                 635                 640 
Tyr Arg Pro Gln Cys Leu Val Leu Thr Gly Pro Pro Asn Phe Arg Pro
                645                 650                 655     
Ala Leu Val Asp Phe Val Gly Thr Phe Thr Arg Asn Leu Ser Leu Met
            660                 665                 670         
Ile Cys Gly His Val Leu Ile Gly Pro His Lys Gln Arg Met Pro Glu
        675                 680                 685             
Leu Gln Leu Ile Ala Asn Gly His Thr Lys Trp Leu Asn Lys Arg Lys
    690                 695                 700                 
Ile Lys Ala Phe Tyr Ser Asp Val Ile Ala Glu Asp Leu Arg Arg Gly
705                 710                 715                 720 
Val Gln Ile Leu Met Gln Ala Ala Gly Leu Gly Arg Met Lys Pro Asn
                725                 730                 735     
Ile Leu Val Val Gly Phe Lys Lys Asn Trp Gln Ser Ala His Pro Ala
            740                 745                 750         
Thr Val Glu Asp Tyr Ile Gly Ile Leu His Asp Ala Phe Glu Phe Asn
        755                 760                 765             
Tyr Gly Val Cys Val Met Arg Met Arg Glu Gly Leu Asn Val Ser Lys
    770                 775                 780                 
Met Met Gln Ala His Ile Asn Pro Val Phe Asp Pro Ala Glu Asp Gly
785                 790                 795                 800 
Lys Glu Ala Ser Ala Arg Gly Ala Arg Pro Ser Val Ser Gly Ala Leu
                805                 810                 815     
Asp Pro Lys Ala Leu Val Lys Glu Glu Gln Ala Thr Thr Ile Phe Gln
            820                 825                 830         
Ser Glu Gln Gly Lys Lys Thr Ile Asp Ile Tyr Trp Leu Phe Asp Asp
        835                 840                 845             
Gly Gly Leu Thr Leu Leu Ile Pro Tyr Leu Leu Gly Arg Lys Arg Arg
    850                 855                 860                 
Trp Ser Lys Cys Lys Ile Arg Val Phe Val Gly Gly Gln Ile Asn Arg
865                 870                 875                 880 
Met Asp Gln Glu Arg Lys Ala Ile Ile Ser Leu Leu Ser Lys Phe Arg
                885                 890                 895     
Leu Gly Phe His Glu Val His Ile Leu Pro Asp Ile Asn Gln Asn Pro
            900                 905                 910         
Arg Ala Glu His Thr Lys Arg Phe Glu Asp Met Ile Ala Pro Phe Arg
        915                 920                 925             
Leu Asn Asp Gly Phe Lys Asp Glu Ala Thr Val Asn Glu Met Arg Arg
    930                 935                 940                 
Asp Cys Pro Trp Lys Ile Ser Asp Glu Glu Ile Thr Lys Asn Arg Val
945                 950                 955                 960 
Lys Ser Leu Arg Gln Val Arg Leu Asn Glu Ile Val Leu Asp Tyr Ser
                965                 970                 975     
Arg Asp Ala Ala Leu Ile Val Ile Thr Leu Pro Ile Gly Arg Lys Gly
            980                 985                 990         
Lys Cys Pro Ser Ser Leu Tyr Met Ala Trp Leu Glu Thr Leu Ser Gln
        995                 1000                1005            
Asp Leu Arg Pro Pro Val Ile Leu Ile Arg Gly Asn Gln Glu Asn Val
    1010                1015                1020                
Leu Thr Phe Tyr Cys Gln
1025                1030


<210> 498
<211> 314
<212> PRT
<213> Homo sapiens

<400> 498
Met Ala Ala Thr Ala Ser Ala Gly Ala Gly Gly Met Asp Gly Lys Pro
 1               5                  10                  15      
Arg Thr Ser Pro Lys Ser Val Lys Phe Leu Phe Gly Gly Leu Ala Gly
            20                  25                  30          
Met Gly Ala Thr Val Phe Val Gln Pro Leu Asp Leu Val Lys Asn Arg
        35                  40                  45              
Met Gln Leu Ser Gly Glu Gly Ala Lys Thr Arg Glu Tyr Lys Thr Ser
    50                  55                  60                  
Phe His Ala Leu Thr Ser Ile Leu Lys Ala Glu Gly Leu Arg Gly Ile
65                  70                  75                  80  
Tyr Thr Gly Leu Ser Ala Gly Leu Leu Arg Gln Ala Thr Tyr Thr Thr
                85                  90                  95      
Thr Arg Leu Gly Ile Tyr Thr Val Leu Phe Glu Arg Leu Thr Gly Ala
            100                 105                 110         
Asp Gly Thr Pro Pro Gly Phe Leu Leu Lys Ala Val Ile Gly Met Thr
        115                 120                 125             
Ala Gly Ala Thr Gly Ala Phe Val Gly Thr Pro Ala Glu Val Ala Leu
    130                 135                 140                 
Ile Arg Met Thr Ala Asp Gly Arg Leu Pro Ala Asp Gln Arg Arg Gly
145                 150                 155                 160 
Tyr Lys Asn Val Phe Asn Ala Leu Ile Arg Ile Thr Arg Glu Glu Gly
                165                 170                 175     
Val Leu Thr Leu Trp Arg Gly Cys Ile Pro Thr Met Ala Arg Ala Val
            180                 185                 190         
Val Val Asn Ala Ala Gln Leu Ala Ser Tyr Ser Gln Ser Lys Gln Phe
        195                 200                 205             
Leu Leu Asp Ser Gly Tyr Phe Ser Asp Asn Ile Leu Cys His Phe Cys
    210                 215                 220                 
Ala Ser Met Ile Ser Gly Leu Val Thr Thr Ala Ala Ser Met Pro Val
225                 230                 235                 240 
Asp Ile Ala Lys Thr Arg Ile Gln Asn Met Arg Met Ile Asp Gly Lys
                245                 250                 255     
Pro Glu Tyr Lys Asn Gly Leu Asp Val Leu Phe Lys Val Val Arg Tyr
            260                 265                 270         
Glu Gly Phe Phe Ser Leu Trp Lys Gly Phe Thr Pro Tyr Tyr Ala Arg
        275                 280                 285             
Leu Gly Pro His Thr Val Leu Thr Phe Ile Phe Leu Glu Gln Met Asn
    290                 295                 300                 
Lys Ala Tyr Lys Arg Leu Phe Leu Ser Gly
305                 310                 


<210> 499
<211> 678
<212> PRT
<213> Homo sapiens

<400> 499
Met Ala Val Lys Val Gln Thr Thr Lys Arg Gly Asp Pro His Glu Leu
 1               5                  10                  15      
Arg Asn Ile Phe Leu Gln Tyr Ala Ser Thr Glu Val Asp Gly Glu Arg
            20                  25                  30          
Tyr Met Thr Pro Glu Asp Phe Val Gln Arg Tyr Leu Gly Leu Tyr Asn
        35                  40                  45              
Asp Pro Asn Ser Asn Pro Lys Ile Val Gln Leu Leu Ala Gly Val Ala
    50                  55                  60                  
Asp Gln Thr Lys Asp Gly Leu Ile Ser Tyr Gln Glu Phe Leu Ala Phe
65                  70                  75                  80  
Glu Ser Val Leu Cys Ala Pro Asp Ser Met Phe Ile Val Ala Phe Gln
                85                  90                  95      
Leu Phe Asp Lys Ser Gly Asn Gly Glu Val Thr Phe Glu Asn Val Lys
            100                 105                 110         
Glu Ile Phe Gly Gln Thr Ile Ile His His His Ile Pro Phe Asn Trp
        115                 120                 125             
Asp Cys Glu Phe Ile Arg Leu His Phe Gly His Asn Arg Lys Lys His
    130                 135                 140                 
Leu Asn Tyr Thr Glu Phe Thr Gln Phe Leu Gln Glu Leu Gln Leu Glu
145                 150                 155                 160 
His Ala Arg Gln Ala Phe Ala Leu Lys Asp Lys Ser Lys Ser Gly Met
                165                 170                 175     
Ile Ser Gly Leu Asp Phe Ser Asp Ile Met Val Thr Ile Arg Ser His
            180                 185                 190         
Met Leu Thr Pro Phe Val Glu Glu Asn Leu Val Ser Ala Ala Gly Gly
        195                 200                 205             
Ser Ile Ser His Gln Val Ser Phe Ser Tyr Phe Asn Ala Phe Asn Ser
    210                 215                 220                 
Leu Leu Asn Asn Met Glu Leu Val Arg Lys Ile Tyr Ser Thr Leu Ala
225                 230                 235                 240 
Gly Thr Arg Lys Asp Val Glu Val Thr Lys Glu Glu Phe Ala Gln Ser
                245                 250                 255     
Ala Ile Arg Tyr Gly Gln Val Thr Pro Leu Glu Ile Asp Ile Leu Tyr
            260                 265                 270         
Gln Leu Ala Asp Leu Tyr Asn Ala Ser Gly Arg Leu Thr Leu Ala Asp
        275                 280                 285             
Ile Glu Arg Ile Ala Pro Leu Ala Glu Gly Ala Leu Pro Tyr Asn Leu
    290                 295                 300                 
Ala Glu Leu Gln Arg Gln Gln Ser Pro Gly Leu Gly Arg Pro Ile Trp
305                 310                 315                 320 
Leu Gln Ile Ala Glu Ser Ala Tyr Arg Phe Thr Leu Gly Ser Val Ala
                325                 330                 335     
Gly Ala Val Gly Ala Thr Ala Val Tyr Pro Ile Asp Leu Val Lys Thr
            340                 345                 350         
Arg Met Gln Asn Gln Arg Gly Ser Gly Ser Val Val Gly Glu Leu Met
        355                 360                 365             
Tyr Lys Asn Ser Phe Asp Cys Phe Lys Lys Val Leu Arg Tyr Glu Gly
    370                 375                 380                 
Phe Phe Gly Leu Tyr Arg Gly Leu Ile Pro Gln Leu Ile Gly Val Ala
385                 390                 395                 400 
Pro Glu Lys Ala Ile Lys Leu Thr Val Asn Asp Phe Val Arg Asp Lys
                405                 410                 415     
Phe Thr Arg Arg Asp Gly Ser Val Pro Leu Pro Ala Glu Val Leu Ala
            420                 425                 430         
Gly Gly Cys Ala Gly Gly Ser Gln Val Ile Phe Thr Asn Pro Leu Glu
        435                 440                 445             
Ile Val Lys Ile Arg Leu Gln Val Ala Gly Glu Ile Thr Thr Gly Pro
    450                 455                 460                 
Arg Val Ser Ala Leu Asn Val Leu Arg Asp Leu Gly Ile Phe Gly Leu
465                 470                 475                 480 
Tyr Lys Gly Ala Lys Ala Cys Phe Leu Arg Asp Ile Pro Phe Ser Ala
                485                 490                 495     
Ile Tyr Phe Pro Val Tyr Ala His Cys Lys Leu Leu Leu Ala Asp Glu
            500                 505                 510         
Asn Gly His Val Gly Gly Leu Asn Leu Leu Ala Ala Gly Ala Met Ala
        515                 520                 525             
Gly Val Pro Ala Ala Ser Leu Val Thr Pro Ala Asp Val Ile Lys Thr
    530                 535                 540                 
Arg Leu Gln Val Ala Ala Arg Ala Gly Gln Thr Thr Tyr Ser Gly Val
545                 550                 555                 560 
Ile Asp Cys Phe Arg Lys Ile Leu Arg Glu Glu Gly Pro Ser Ala Phe
                565                 570                 575     
Trp Lys Gly Thr Ala Ala Arg Val Phe Arg Ser Ser Pro Gln Phe Gly
            580                 585                 590         
Val Thr Leu Ala His Tyr Glu Val Leu Gln Arg Trp Phe Tyr Ile Asp
        595                 600                 605             
Phe Gly Gly Leu Lys Pro Ala Gly Ser Glu Pro Thr Pro Lys Ser Arg
    610                 615                 620                 
Ile Ala Asp Leu Pro Pro Ala Asn Pro Asp His Ile Gly Gly Tyr Arg
625                 630                 635                 640 
Leu Ala Thr Ala Thr Phe Ala Gly Ile Glu Asn Lys Phe Gly Leu Tyr
                645                 650                 655     
Leu Pro Lys Phe Lys Ser Pro Ser Val Ala Val Val Gln Pro Lys Ala
            660                 665                 670         
Ala Val Ala Ala Thr Gln
        675             


<210> 500
<211> 911
<212> PRT
<213> Homo sapiens

<400> 500
Met Glu Glu Leu Gln Asp Asp Tyr Glu Asp Met Met Glu Glu Asn Leu
 1               5                  10                  15      
Glu Gln Glu Glu Tyr Glu Asp Pro Asp Ile Pro Glu Ser Gln Met Glu
            20                  25                  30          
Glu Pro Ala Ala His Asp Thr Glu Ala Thr Ala Thr Asp Tyr His Thr
        35                  40                  45              
Thr Ser His Pro Gly Thr His Lys Val Tyr Val Glu Leu Gln Glu Leu
    50                  55                  60                  
Val Met Asp Glu Lys Asn Gln Glu Leu Arg Trp Met Glu Ala Ala Arg
65                  70                  75                  80  
Trp Val Gln Leu Glu Glu Asn Leu Gly Glu Asn Gly Ala Trp Gly Arg
                85                  90                  95      
Pro His Leu Ser His Leu Thr Phe Trp Ser Leu Leu Glu Leu Arg Arg
            100                 105                 110         
Val Phe Thr Lys Gly Thr Val Leu Leu Asp Leu Gln Glu Thr Ser Leu
        115                 120                 125             
Ala Gly Val Ala Asn Gln Leu Leu Asp Arg Phe Ile Phe Glu Asp Gln
    130                 135                 140                 
Ile Arg Pro Gln Asp Arg Glu Glu Leu Leu Arg Ala Leu Leu Leu Lys
145                 150                 155                 160 
His Ser His Ala Gly Glu Leu Glu Ala Leu Gly Gly Val Lys Pro Ala
                165                 170                 175     
Val Leu Thr Arg Ser Gly Asp Pro Ser Gln Pro Leu Leu Pro Gln His
            180                 185                 190         
Ser Ser Leu Glu Thr Gln Leu Phe Cys Glu Gln Gly Asp Gly Gly Thr
        195                 200                 205             
Glu Gly His Ser Pro Ser Gly Ile Leu Glu Lys Ile Pro Pro Asp Ser
    210                 215                 220                 
Glu Ala Thr Leu Val Leu Val Gly Arg Ala Asp Phe Leu Glu Gln Pro
225                 230                 235                 240 
Val Leu Gly Phe Val Arg Leu Gln Glu Ala Ala Glu Leu Glu Ala Val
                245                 250                 255     
Glu Leu Pro Val Pro Ile Arg Phe Leu Phe Val Leu Leu Gly Pro Glu
            260                 265                 270         
Ala Pro His Ile Asp Tyr Thr Gln Leu Gly Arg Ala Ala Ala Thr Leu
        275                 280                 285             
Met Ser Glu Arg Val Phe Arg Ile Asp Ala Tyr Met Ala Gln Ser Arg
    290                 295                 300                 
Gly Glu Leu Leu His Ser Leu Glu Gly Phe Leu Asp Cys Ser Leu Val
305                 310                 315                 320 
Leu Pro Pro Thr Asp Ala Pro Ser Glu Gln Ala Leu Leu Ser Leu Val
                325                 330                 335     
Pro Val Gln Arg Glu Leu Leu Arg Arg Arg Tyr Gln Ser Ser Pro Ala
            340                 345                 350         
Lys Pro Asp Ser Ser Phe Tyr Lys Gly Leu Asp Leu Asn Gly Gly Pro
        355                 360                 365             
Asp Asp Pro Leu Gln Gln Thr Gly Gln Leu Phe Gly Gly Leu Val Arg
    370                 375                 380                 
Asp Ile Arg Arg Arg Tyr Pro Tyr Tyr Leu Ser Asp Ile Thr Asp Ala
385                 390                 395                 400 
Phe Ser Pro Gln Val Leu Ala Ala Val Ile Phe Ile Tyr Phe Ala Ala
                405                 410                 415     
Leu Ser Pro Ala Ile Thr Phe Gly Gly Leu Leu Gly Glu Lys Thr Arg
            420                 425                 430         
Asn Gln Met Gly Val Ser Glu Leu Leu Ile Ser Thr Ala Val Gln Gly
        435                 440                 445             
Ile Leu Phe Ala Leu Leu Gly Ala Gln Pro Leu Leu Val Val Gly Phe
    450                 455                 460                 
Ser Gly Pro Leu Leu Val Phe Glu Glu Ala Phe Phe Ser Phe Cys Glu
465                 470                 475                 480 
Thr Asn Gly Leu Glu Tyr Ile Val Gly Arg Val Trp Ile Gly Phe Trp
                485                 490                 495     
Leu Ile Leu Leu Val Val Leu Val Val Ala Phe Glu Gly Ser Phe Leu
            500                 505                 510         
Val Arg Phe Ile Ser Arg Tyr Thr Gln Glu Ile Phe Ser Phe Leu Ile
        515                 520                 525             
Ser Leu Ile Phe Ile Tyr Glu Thr Phe Ser Lys Leu Ile Lys Ile Phe
    530                 535                 540                 
Gln Asp His Pro Leu Gln Lys Thr Tyr Asn Tyr Asn Val Leu Met Val
545                 550                 555                 560 
Pro Lys Pro Gln Gly Pro Leu Pro Asn Thr Ala Leu Leu Ser Leu Val
                565                 570                 575     
Leu Met Ala Gly Thr Phe Phe Phe Ala Met Met Leu Arg Lys Phe Lys
            580                 585                 590         
Asn Ser Ser Tyr Phe Pro Gly Lys Leu Arg Arg Val Ile Gly Asp Phe
        595                 600                 605             
Gly Val Pro Ile Ser Ile Leu Ile Met Val Leu Val Asp Phe Phe Ile
    610                 615                 620                 
Gln Asp Thr Tyr Thr Gln Lys Leu Ser Val Pro Asp Gly Phe Lys Val
625                 630                 635                 640 
Ser Asn Ser Ser Ala Arg Gly Trp Val Ile His Pro Leu Gly Leu Arg
                645                 650                 655     
Ser Glu Phe Pro Ile Trp Met Met Phe Ala Ser Ala Leu Pro Ala Leu
            660                 665                 670         
Leu Val Phe Ile Leu Ile Phe Leu Glu Ser Gln Ile Thr Thr Leu Ile
        675                 680                 685             
Val Ser Lys Pro Glu Arg Lys Met Val Lys Gly Ser Gly Phe His Leu
    690                 695                 700                 
Asp Leu Leu Leu Val Val Gly Met Gly Gly Val Ala Ala Leu Phe Gly
705                 710                 715                 720 
Met Pro Trp Leu Ser Ala Thr Thr Val Arg Ser Val Thr His Ala Asn
                725                 730                 735     
Ala Leu Thr Val Met Gly Lys Ala Ser Thr Pro Gly Ala Ala Ala Gln
            740                 745                 750         
Ile Gln Glu Val Lys Glu Gln Arg Ile Ser Gly Leu Leu Val Ala Val
        755                 760                 765             
Leu Val Gly Leu Ser Ile Leu Met Glu Pro Ile Leu Ser Arg Ile Pro
    770                 775                 780                 
Leu Ala Val Leu Phe Gly Ile Phe Leu Tyr Met Gly Val Thr Ser Leu
785                 790                 795                 800 
Ser Gly Ile Gln Leu Phe Asp Arg Ile Leu Leu Leu Phe Lys Pro Pro
                805                 810                 815     
Lys Tyr His Pro Asp Val Pro Tyr Val Lys Arg Val Lys Thr Trp Arg
            820                 825                 830         
Met His Leu Phe Thr Gly Ile Gln Ile Ile Cys Leu Ala Val Leu Trp
        835                 840                 845             
Val Val Lys Ser Thr Pro Ala Ser Leu Ala Leu Pro Phe Val Leu Ile
    850                 855                 860                 
Leu Thr Val Pro Leu Arg Arg Val Leu Leu Pro Leu Ile Phe Arg Asn
865                 870                 875                 880 
Val Glu Leu Gln Cys Leu Asp Ala Asp Asp Ala Lys Ala Thr Phe Asp
                885                 890                 895     
Glu Glu Glu Gly Arg Asp Glu Tyr Asp Glu Val Ala Met Pro Val
            900                 905                 910     


<210> 501
<211> 261
<212> PRT
<213> Homo sapiens

<400> 501
Met Glu Gly Gly Leu Gly Arg Ala Val Cys Leu Leu Thr Gly Ala Ser
 1               5                  10                  15      
Arg Gly Phe Gly Arg Thr Leu Ala Pro Leu Leu Ala Ser Leu Leu Ser
            20                  25                  30          
Pro Gly Ser Val Leu Val Leu Ser Ala Arg Asn Asp Glu Ala Leu Arg
        35                  40                  45              
Gln Leu Glu Ala Glu Leu Gly Ala Glu Arg Ser Gly Leu Arg Val Val
    50                  55                  60                  
Arg Val Pro Ala Asp Leu Gly Ala Glu Ala Gly Leu Gln Gln Leu Leu
65                  70                  75                  80  
Gly Ala Leu Arg Glu Leu Pro Arg Pro Lys Gly Leu Gln Arg Leu Leu
                85                  90                  95      
Leu Ile Asn Asn Ala Gly Ser Leu Gly Asp Val Ser Lys Gly Phe Val
            100                 105                 110         
Asp Leu Ser Asp Ser Thr Gln Val Asn Asn Tyr Trp Ala Leu Asn Leu
        115                 120                 125             
Thr Ser Met Leu Cys Leu Thr Ser Ser Val Leu Lys Ala Phe Pro Asp
    130                 135                 140                 
Ser Pro Gly Leu Asn Arg Thr Val Val Asn Ile Ser Ser Leu Cys Ala
145                 150                 155                 160 
Leu Gln Pro Phe Lys Gly Trp Ala Leu Tyr Cys Ala Gly Lys Ala Ala
                165                 170                 175     
Arg Asp Met Leu Phe Gln Val Leu Ala Leu Glu Glu Pro Asn Val Arg
            180                 185                 190         
Val Leu Asn Tyr Ala Pro Gly Pro Leu Asp Thr Asp Met Gln Gln Leu
        195                 200                 205             
Ala Arg Glu Thr Ser Val Asp Pro Asp Met Arg Lys Gly Leu Gln Glu
    210                 215                 220                 
Leu Lys Ala Lys Gly Lys Leu Val Asp Cys Lys Val Ser Ala Gln Lys
225                 230                 235                 240 
Leu Leu Ser Leu Leu Glu Lys Asp Glu Phe Lys Ser Gly Ala His Val
                245                 250                 255     
Asp Phe Tyr Asp Lys
            260     


<210> 502
<211> 504
<212> PRT
<213> Homo sapiens

<400> 502
Met Val Leu Ala Asp Leu Gly Arg Lys Ile Thr Ser Ala Leu Arg Ser
 1               5                  10                  15      
Leu Ser Asn Ala Thr Ile Ile Asn Glu Glu Val Leu Asn Ala Met Leu
            20                  25                  30          
Lys Glu Val Cys Thr Ala Leu Leu Glu Ala Asp Val Asn Ile Lys Leu
        35                  40                  45              
Val Lys Gln Leu Arg Glu Asn Val Lys Ser Ala Ile Asp Leu Glu Glu
    50                  55                  60                  
Met Ala Ser Gly Leu Asn Lys Arg Lys Met Ile Gln His Ala Val Phe
65                  70                  75                  80  
Lys Glu Leu Val Lys Leu Val Asp Pro Gly Val Lys Ala Trp Thr Pro
                85                  90                  95      
Thr Lys Gly Lys Gln Asn Val Ile Met Phe Val Gly Leu Gln Gly Ser
            100                 105                 110         
Gly Lys Thr Thr Thr Cys Ser Lys Leu Ala Tyr Tyr Tyr Gln Arg Lys
        115                 120                 125             
Gly Trp Lys Thr Cys Leu Ile Cys Ala Asp Thr Phe Arg Ala Gly Ala
    130                 135                 140                 
Phe Asp Gln Leu Lys Gln Asn Ala Thr Lys Ala Arg Ile Pro Phe Tyr
145                 150                 155                 160 
Gly Ser Tyr Thr Glu Met Asp Pro Val Ile Ile Ala Ser Glu Gly Val
                165                 170                 175     
Glu Lys Phe Lys Asn Glu Asn Phe Glu Ile Ile Ile Val Asp Thr Ser
            180                 185                 190         
Gly Arg His Lys Gln Glu Asp Ser Leu Phe Glu Glu Met Leu Gln Val
        195                 200                 205             
Ala Asn Ala Ile Gln Pro Asp Asn Ile Val Tyr Val Met Asp Ala Ser
    210                 215                 220                 
Ile Gly Gln Ala Cys Glu Ala Gln Ala Lys Ala Phe Lys Asp Lys Val
225                 230                 235                 240 
Asp Val Ala Ser Val Ile Val Thr Lys Leu Asp Gly His Ala Lys Gly
                245                 250                 255     
Gly Gly Ala Leu Ser Ala Val Ala Ala Thr Lys Ser Pro Ile Ile Phe
            260                 265                 270         
Ile Gly Thr Gly Glu His Ile Asp Asp Phe Glu Pro Phe Lys Thr Gln
        275                 280                 285             
Pro Phe Ile Ser Lys Leu Leu Gly Met Gly Asp Ile Glu Gly Leu Ile
    290                 295                 300                 
Asp Lys Val Asn Glu Leu Lys Leu Asp Asp Asn Glu Ala Leu Ile Glu
305                 310                 315                 320 
Lys Leu Lys His Gly Gln Phe Thr Leu Arg Asp Met Tyr Glu Gln Phe
                325                 330                 335     
Gln Asn Ile Met Lys Met Gly Pro Phe Ser Gln Ile Leu Gly Met Ile
            340                 345                 350         
Pro Gly Phe Gly Thr Asp Phe Met Ser Lys Gly Asn Glu Gln Glu Ser
        355                 360                 365             
Met Ala Arg Leu Lys Lys Leu Met Thr Ile Met Asp Ser Met Asn Asp
    370                 375                 380                 
Gln Glu Leu Asp Ser Thr Asp Gly Ala Lys Val Phe Ser Lys Gln Pro
385                 390                 395                 400 
Gly Arg Ile Gln Arg Val Ala Arg Gly Ser Gly Val Ser Thr Arg Asp
                405                 410                 415     
Val Gln Glu Leu Leu Thr Gln Tyr Thr Lys Phe Ala Gln Met Val Lys
            420                 425                 430         
Lys Met Gly Gly Ile Lys Gly Leu Phe Lys Gly Gly Asp Met Ser Lys
        435                 440                 445             
Asn Val Ser Gln Ser Gln Met Ala Lys Leu Asn Gln Gln Met Ala Lys
    450                 455                 460                 
Met Met Asp Pro Arg Val Leu His His Met Gly Gly Met Ala Gly Leu
465                 470                 475                 480 
Gln Ser Met Met Arg Gln Phe Gln Gln Gly Ala Ala Gly Asn Met Lys
                485                 490                 495     
Gly Met Met Gly Phe Asn Asn Met
            500                 


<210> 503
<211> 519
<212> PRT
<213> Homo sapiens

<400> 503
Met Asp Leu Val Gly Val Ala Ser Pro Glu Pro Gly Thr Ala Ala Ala
 1               5                  10                  15      
Trp Gly Pro Ser Lys Cys Pro Trp Ala Ile Pro Gln Asn Thr Ile Ser
            20                  25                  30          
Cys Ser Leu Ala Asp Val Met Ser Glu Gln Leu Ala Lys Glu Leu Gln
        35                  40                  45              
Leu Glu Glu Glu Ala Ala Val Phe Pro Glu Val Ala Val Ala Glu Gly
    50                  55                  60                  
Pro Phe Ile Thr Gly Glu Asn Ile Asp Thr Ser Ser Asp Leu Met Leu
65                  70                  75                  80  
Ala Gln Met Leu Gln Met Glu Tyr Asp Arg Glu Tyr Asp Ala Gln Leu
                85                  90                  95      
Arg Arg Glu Glu Lys Lys Phe Asn Gly Asp Ser Lys Val Ser Ile Ser
            100                 105                 110         
Phe Glu Asn Tyr Arg Lys Val His Pro Tyr Glu Asp Ser Asp Ser Ser
        115                 120                 125             
Glu Asp Glu Val Asp Trp Gln Asp Thr Arg Asp Asp Pro Tyr Arg Pro
    130                 135                 140                 
Ala Lys Pro Val Pro Thr Pro Lys Lys Gly Phe Ile Gly Lys Gly Lys
145                 150                 155                 160 
Asp Ile Thr Thr Lys His Asp Glu Val Val Cys Gly Arg Lys Asn Thr
                165                 170                 175     
Ala Arg Met Glu Asn Phe Ala Pro Glu Phe Gln Val Gly Asp Gly Ile
            180                 185                 190         
Gly Met Asp Leu Lys Leu Ser Asn His Val Phe Asn Ala Leu Lys Gln
        195                 200                 205             
His Ala Tyr Ser Glu Glu Arg Arg Ser Ala Arg Leu His Glu Lys Lys
    210                 215                 220                 
Glu His Ser Thr Ala Glu Lys Ala Val Asp Pro Lys Thr Arg Leu Leu
225                 230                 235                 240 
Met Tyr Lys Met Val Asn Ser Gly Met Leu Glu Thr Ile Thr Gly Cys
                245                 250                 255     
Ile Ser Thr Gly Lys Glu Ser Val Val Phe His Ala Tyr Gly Gly Ser
            260                 265                 270         
Met Glu Asp Glu Lys Glu Asp Ser Lys Val Ile Pro Thr Glu Cys Ala
        275                 280                 285             
Ile Lys Val Phe Lys Thr Thr Leu Asn Glu Phe Lys Asn Arg Asp Lys
    290                 295                 300                 
Tyr Ile Lys Asp Asp Phe Arg Phe Lys Asp Arg Phe Ser Lys Leu Asn
305                 310                 315                 320 
Pro Arg Lys Ile His Arg Met Trp Ala Glu Lys Glu Met His Asn Leu
                325                 330                 335     
Ala Arg Met Gln Arg Ala Gly Ile Pro Cys Pro Thr Val Val Leu Leu
            340                 345                 350         
Lys Lys His Ile Leu Val Met Ser Phe Ile Gly His Asp Gln Val Pro
        355                 360                 365             
Ala Pro Lys Leu Lys Glu Val Lys Leu Asn Ser Glu Glu Met Lys Glu
    370                 375                 380                 
Ala Tyr Tyr Gln Thr Leu His Leu Met Arg Gln Leu Tyr His Glu Cys
385                 390                 395                 400 
Thr Leu Val His Ala Asp Leu Ser Glu Tyr Asn Met Leu Trp His Ala
                405                 410                 415     
Gly Lys Val Trp Leu Ile Asp Val Ser Gln Ser Val Glu Pro Thr His
            420                 425                 430         
Pro His Gly Leu Glu Phe Leu Phe Arg Asp Cys Arg Asn Val Ser Gln
        435                 440                 445             
Phe Phe Gln Lys Gly Gly Val Lys Glu Ala Leu Ser Glu Arg Glu Leu
    450                 455                 460                 
Phe Asn Ala Val Ser Gly Leu Asn Ile Thr Ala Asp Asn Glu Ala Asp
465                 470                 475                 480 
Phe Leu Ala Glu Ile Glu Ala Leu Glu Lys Met Asn Glu Asp His Val
                485                 490                 495     
Gln Lys Asn Gly Arg Lys Ala Ala Ser Phe Leu Lys Asp Asp Gly Asp
            500                 505                 510         
Pro Pro Leu Leu Tyr Asp Glu
        515                 


<210> 504
<211> 772
<212> PRT
<213> Homo sapiens

<400> 504
Met Ala Ala Glu Ser Ala Leu Gln Val Val Glu Lys Leu Gln Ala Arg
 1               5                  10                  15      
Leu Ala Ala Asn Pro Asp Pro Lys Lys Leu Leu Lys Tyr Leu Lys Lys
            20                  25                  30          
Leu Ser Thr Leu Pro Ile Thr Val Asp Ile Leu Ala Glu Thr Gly Val
        35                  40                  45              
Gly Lys Thr Val Asn Ser Leu Arg Lys His Glu His Val Gly Ser Phe
    50                  55                  60                  
Ala Arg Asp Leu Val Ala Gln Trp Lys Lys Leu Val Pro Val Glu Arg
65                  70                  75                  80  
Asn Ala Glu Pro Asp Glu Gln Asp Phe Glu Lys Ser Asn Ser Arg Lys
                85                  90                  95      
Arg Pro Arg Asp Ala Leu Gln Lys Glu Glu Glu Met Glu Gly Asp Tyr
            100                 105                 110         
Gln Glu Thr Trp Lys Ala Thr Gly Ser Arg Ser Tyr Ser Pro Asp His
        115                 120                 125             
Arg Gln Lys Lys His Arg Lys Leu Ser Glu Leu Glu Arg Pro His Lys
    130                 135                 140                 
Val Ser His Gly His Glu Arg Arg Asp Glu Arg Lys Arg Cys His Arg
145                 150                 155                 160 
Met Ser Pro Thr Tyr Ser Ser Asp Pro Glu Ser Ser Asp Tyr Gly His
                165                 170                 175     
Val Gln Ser Pro Pro Ser Cys Thr Ser Pro His Gln Met Tyr Val Asp
            180                 185                 190         
His Tyr Arg Ser Leu Glu Glu Asp Gln Glu Pro Ile Val Ser His Gln
        195                 200                 205             
Lys Pro Gly Lys Gly His Ser Asn Ala Phe Gln Asp Arg Leu Gly Ala
    210                 215                 220                 
Ser Gln Glu Arg His Leu Gly Glu Pro His Gly Lys Gly Val Val Ser
225                 230                 235                 240 
Gln Asn Lys Glu His Lys Ser Ser His Lys Asp Lys Arg Pro Val Asp
                245                 250                 255     
Ala Lys Ser Asp Glu Lys Ala Ser Val Val Ser Arg Glu Lys Ser His
            260                 265                 270         
Lys Ala Leu Ser Lys Glu Glu Asn Arg Arg Pro Pro Ser Gly Asp Asn
        275                 280                 285             
Ala Arg Glu Lys Pro Pro Ser Ser Gly Val Lys Lys Glu Lys Asp Arg
    290                 295                 300                 
Glu Gly Ser Ser Leu Lys Lys Lys Cys Leu Pro Pro Ser Glu Ala Ala
305                 310                 315                 320 
Ser Asp Asn His Leu Lys Lys Pro Lys His Arg Asp Pro Glu Lys Ala
                325                 330                 335     
Lys Leu Asp Lys Ser Lys Gln Gly Leu Asp Ser Phe Asp Thr Gly Lys
            340                 345                 350         
Gly Ala Gly Asp Leu Leu Pro Lys Val Lys Glu Lys Gly Ser Asn Asn
        355                 360                 365             
Leu Lys Thr Pro Glu Gly Lys Val Lys Thr Asn Leu Asp Arg Lys Ser
    370                 375                 380                 
Leu Gly Ser Leu Pro Lys Val Glu Glu Thr Asp Met Glu Asp Glu Phe
385                 390                 395                 400 
Glu Gln Pro Thr Met Ser Phe Glu Ser Tyr Leu Ser Tyr Asp Gln Pro
                405                 410                 415     
Arg Lys Lys Lys Lys Lys Ile Val Lys Thr Ser Ala Thr Ala Leu Gly
            420                 425                 430         
Asp Lys Gly Leu Lys Lys Asn Asp Ser Lys Ser Thr Gly Lys Asn Leu
        435                 440                 445             
Asp Ser Val Gln Lys Leu Pro Lys Val Asn Lys Thr Lys Ser Glu Lys
    450                 455                 460                 
Pro Ala Gly Ala Asp Leu Ala Lys Leu Arg Lys Val Pro Asp Val Leu
465                 470                 475                 480 
Pro Val Leu Pro Asp Leu Pro Leu Pro Ala Ile Gln Ala Asn Tyr Arg
                485                 490                 495     
Pro Leu Pro Ser Leu Glu Leu Ile Ser Ser Phe Gln Pro Lys Arg Lys
            500                 505                 510         
Ala Phe Ser Ser Pro Gln Glu Glu Glu Glu Ala Gly Phe Thr Gly Arg
        515                 520                 525             
Arg Met Asn Ser Lys Met Gln Val Tyr Ser Gly Ser Lys Cys Ala Tyr
    530                 535                 540                 
Leu Pro Lys Met Met Thr Leu His Gln Gln Cys Ile Arg Val Leu Lys
545                 550                 555                 560 
Asn Asn Ile Asp Ser Ile Phe Glu Val Gly Gly Val Pro Tyr Ser Val
                565                 570                 575     
Leu Glu Pro Val Leu Glu Arg Cys Thr Pro Asp Gln Leu Tyr Arg Ile
            580                 585                 590         
Glu Glu Tyr Asn His Val Leu Ile Glu Glu Thr Asp Gln Leu Trp Lys
        595                 600                 605             
Val His Cys His Arg Asp Phe Lys Glu Glu Arg Pro Glu Glu Tyr Glu
    610                 615                 620                 
Ser Trp Arg Glu Met Tyr Leu Arg Leu Gln Asp Ala Arg Glu Gln Arg
625                 630                 635                 640 
Leu Arg Val Leu Thr Lys Asn Ile Gln Phe Ala His Ala Asn Lys Pro
                645                 650                 655     
Lys Gly Arg Gln Ala Lys Met Ala Phe Val Asn Ser Val Ala Lys Pro
            660                 665                 670         
Pro Arg Asp Val Arg Arg Arg Gln Glu Lys Phe Gly Thr Gly Gly Ala
        675                 680                 685             
Ala Val Pro Glu Lys Ile Lys Ile Lys Pro Ala Pro Tyr Pro Met Gly
    690                 695                 700                 
Ser Ser His Ala Ser Ala Ser Ser Ile Ser Phe Asn Pro Ser Pro Glu
705                 710                 715                 720 
Glu Pro Ala Tyr Asp Gly Pro Ser Thr Ser Ser Ala His Leu Ala Pro
                725                 730                 735     
Val Val Ser Ser Thr Val Ser Tyr Asp Pro Arg Lys Pro Thr Val Lys
            740                 745                 750         
Lys Ile Ala Pro Met Met Ala Lys Thr Ile Lys Ala Phe Lys Asn Arg
        755                 760                 765             
Phe Ser Arg Arg
    770         


<210> 505
<211> 246
<212> PRT
<213> Homo sapiens

<400> 505
Met Ala Phe Leu Arg Ser Met Trp Gly Val Leu Ser Ala Leu Gly Arg
 1               5                  10                  15      
Ser Gly Ala Glu Leu Cys Thr Gly Cys Gly Ser Arg Leu Arg Ser Pro
            20                  25                  30          
Phe Ser Phe Val Tyr Leu Pro Arg Trp Phe Ser Ser Val Leu Ala Ser
        35                  40                  45              
Cys Pro Lys Lys Pro Val Ser Ser Tyr Leu Arg Phe Ser Lys Glu Gln
    50                  55                  60                  
Leu Pro Ile Phe Lys Ala Gln Asn Pro Asp Ala Lys Thr Thr Glu Leu
65                  70                  75                  80  
Ile Arg Arg Ile Ala Gln Arg Trp Arg Glu Leu Pro Asp Ser Lys Lys
                85                  90                  95      
Lys Ile Tyr Gln Asp Ala Tyr Arg Ala Glu Trp Gln Val Tyr Lys Glu
            100                 105                 110         
Glu Ile Ser Arg Phe Lys Glu Gln Leu Thr Pro Ser Gln Ile Met Ser
        115                 120                 125             
Leu Glu Lys Glu Ile Met Asp Lys His Leu Lys Arg Lys Ala Met Thr
    130                 135                 140                 
Lys Lys Lys Glu Leu Thr Leu Leu Gly Lys Pro Lys Arg Pro Arg Ser
145                 150                 155                 160 
Ala Tyr Asn Val Tyr Val Ala Glu Arg Phe Gln Glu Ala Lys Gly Asp
                165                 170                 175     
Ser Pro Gln Glu Lys Leu Lys Thr Val Lys Glu Asn Trp Lys Asn Leu
            180                 185                 190         
Ser Asp Ser Glu Lys Glu Leu Tyr Ile Gln His Ala Lys Glu Asp Glu
        195                 200                 205             
Thr Arg Tyr His Asn Glu Met Lys Ser Trp Glu Glu Gln Met Ile Glu
    210                 215                 220                 
Val Gly Arg Lys Asp Leu Leu Arg Arg Thr Ile Lys Lys Gln Arg Lys
225                 230                 235                 240 
Tyr Gly Ala Glu Glu Cys
                245     


<210> 506
<211> 246
<212> PRT
<213> Homo sapiens

<400> 506
Met Ala Phe Leu Arg Ser Met Trp Gly Val Leu Ser Ala Leu Gly Arg
 1               5                  10                  15      
Ser Gly Ala Glu Leu Cys Thr Gly Cys Gly Ser Arg Leu Arg Ser Pro
            20                  25                  30          
Phe Ser Phe Val Tyr Leu Pro Arg Trp Phe Ser Ser Val Leu Ala Ser
        35                  40                  45              
Cys Pro Lys Lys Pro Val Ser Ser Tyr Leu Arg Phe Ser Lys Glu Gln
    50                  55                  60                  
Leu Pro Ile Phe Lys Ala Gln Asn Pro Asp Ala Lys Thr Thr Glu Leu
65                  70                  75                  80  
Ile Arg Arg Ile Ala Gln Arg Trp Arg Glu Leu Pro Asp Ser Lys Lys
                85                  90                  95      
Lys Ile Tyr Gln Asp Ala Tyr Arg Ala Glu Trp Gln Val Tyr Lys Glu
            100                 105                 110         
Glu Ile Ser Arg Phe Lys Glu Gln Leu Thr Pro Ser Gln Ile Met Ser
        115                 120                 125             
Leu Glu Lys Glu Ile Met Asp Lys His Leu Lys Arg Lys Ala Met Thr
    130                 135                 140                 
Lys Lys Lys Glu Leu Thr Leu Leu Gly Lys Pro Lys Arg Pro Arg Ser
145                 150                 155                 160 
Ala Tyr Asn Val Tyr Val Ala Glu Arg Phe Gln Glu Ala Lys Gly Asp
                165                 170                 175     
Ser Pro Gln Glu Lys Leu Lys Thr Val Lys Glu Asn Trp Lys Asn Leu
            180                 185                 190         
Ser Asp Ser Glu Lys Glu Leu Tyr Ile Gln His Ala Lys Glu Asp Glu
        195                 200                 205             
Thr Arg Tyr His Asn Glu Met Lys Ser Trp Glu Glu Gln Met Ile Glu
    210                 215                 220                 
Val Gly Arg Lys Asp Leu Leu Arg Arg Thr Ile Lys Lys Gln Arg Lys
225                 230                 235                 240 
Tyr Gly Ala Glu Glu Cys
                245     


<210> 507
<211> 303
<212> PRT
<213> Homo sapiens

<400> 507
Met Ser Asp Ala Gly Gly Gly Lys Lys Pro Pro Val Asp Pro Gln Ala
 1               5                  10                  15      
Gly Pro Gly Pro Gly Pro Gly Arg Ala Ala Gly Glu Arg Gly Leu Ser
            20                  25                  30          
Gly Ser Phe Pro Leu Val Leu Lys Lys Leu Met Glu Asn Pro Pro Arg
        35                  40                  45              
Glu Ala Arg Leu Asp Lys Glu Lys Gly Lys Glu Lys Leu Glu Glu Asp
    50                  55                  60                  
Glu Ala Ala Ala Ala Ser Thr Met Ala Val Ser Ala Ser Leu Met Pro
65                  70                  75                  80  
Pro Ile Trp Asp Lys Thr Ile Pro Tyr Asp Gly Glu Ser Phe His Leu
                85                  90                  95      
Glu Tyr Met Asp Leu Asp Glu Phe Leu Leu Glu Asn Gly Ile Pro Ala
            100                 105                 110         
Ser Pro Thr His Leu Ala His Asn Leu Leu Leu Pro Val Ala Glu Leu
        115                 120                 125             
Glu Gly Lys Glu Ser Ala Ser Ser Ser Thr Ala Ser Pro Pro Ser Ser
    130                 135                 140                 
Ser Thr Ala Ile Phe Gln Pro Ser Glu Thr Val Ser Ser Thr Glu Ser
145                 150                 155                 160 
Ser Leu Glu Lys Glu Arg Glu Thr Pro Ser Pro Ile Asp Pro Asn Cys
                165                 170                 175     
Val Glu Val Asp Val Asn Phe Asn Pro Asp Pro Ala Asp Leu Val Leu
            180                 185                 190         
Ser Ser Val Pro Gly Gly Glu Leu Phe Asn Pro Arg Lys His Lys Phe
        195                 200                 205             
Ala Glu Glu Asp Leu Lys Pro Gln Pro Met Ile Lys Lys Ala Lys Lys
    210                 215                 220                 
Val Phe Val Pro Asp Glu Gln Lys Asp Glu Lys Tyr Trp Thr Arg Arg
225                 230                 235                 240 
Lys Lys Asn Asn Val Ala Ala Lys Arg Ser Arg Asp Ala Arg Arg Leu
                245                 250                 255     
Lys Glu Asn Gln Ile Thr Ile Arg Ala Ala Phe Leu Glu Lys Glu Asn
            260                 265                 270         
Thr Ala Leu Arg Thr Glu Val Ala Glu Leu Arg Lys Glu Val Gly Lys
        275                 280                 285             
Cys Lys Thr Ile Val Ser Lys Tyr Glu Thr Lys Tyr Gly Pro Leu
    290                 295                 300             


<210> 508
<211> 449
<212> PRT
<213> Homo sapiens

<400> 508
Met Leu Trp Lys Leu Val Glu Asn Val Lys Tyr Glu Asp Ile Tyr Glu
 1               5                  10                  15      
Asp Arg His Asp Gly Val Pro Ser His Ser Ser Arg Leu Ser Gln Leu
            20                  25                  30          
Gly Ser Val Ser Gln Gly Pro Tyr Ser Ser Ala Pro Pro Leu Ser His
        35                  40                  45              
Thr Pro Ser Ser Asp Phe Gln Pro Pro Tyr Phe Pro Pro Pro Tyr Gln
    50                  55                  60                  
Pro Leu Pro Tyr His Gln Ser Gln Asp Pro Tyr Ser His Val Asn Asp
65                  70                  75                  80  
Pro Tyr Ser Leu Asn Pro Leu His Gln Pro Gln Gln His Pro Trp Gly
                85                  90                  95      
Gln Arg Gln Arg Gln Glu Val Gly Ser Glu Ala Gly Ser Leu Leu Pro
            100                 105                 110         
Gln Pro Arg Ala Ala Leu Pro Gln Leu Ser Gly Leu Asp Pro Arg Arg
        115                 120                 125             
Asp Tyr His Ser Val Arg Arg Pro Asp Val Leu Leu His Ser Ala His
    130                 135                 140                 
His Gly Leu Asp Ala Gly Met Gly Asp Ser Leu Ser Leu His Gly Leu
145                 150                 155                 160 
Gly His Pro Gly Met Glu Asp Val Gln Ser Val Glu Asp Ala Asn Asn
                165                 170                 175     
Ser Gly Met Asn Leu Leu Asp Gln Ser Val Ile Lys Lys Val Pro Val
            180                 185                 190         
Pro Pro Lys Ser Val Thr Ser Leu Met Met Asn Lys Asp Gly Phe Leu
        195                 200                 205             
Gly Gly Met Ser Val Asn Thr Gly Glu Val Phe Cys Ser Val Pro Gly
    210                 215                 220                 
Arg Leu Ser Leu Leu Ser Ser Thr Ser Lys Tyr Lys Val Thr Val Gly
225                 230                 235                 240 
Glu Val Gln Arg Arg Leu Ser Pro Pro Glu Cys Leu Asn Ala Ser Leu
                245                 250                 255     
Leu Gly Gly Val Leu Arg Arg Ala Lys Ser Lys Asn Gly Gly Arg Ser
            260                 265                 270         
Leu Arg Glu Arg Leu Glu Lys Ile Gly Leu Asn Leu Pro Ala Gly Arg
        275                 280                 285             
Arg Lys Ala Ala Asn Val Thr Leu Leu Thr Ser Leu Val Glu Gly Glu
    290                 295                 300                 
Ala Val His Leu Ala Arg Asp Phe Gly Tyr Ile Cys Glu Thr Glu Phe
305                 310                 315                 320 
Pro Ala Lys Ala Val Ser Glu Tyr Leu Asn Arg Gln His Thr Asp Pro
                325                 330                 335     
Ser Asp Leu His Ser Arg Lys Asn Met Leu Leu Ala Thr Lys Gln Leu
            340                 345                 350         
Cys Lys Glu Phe Thr Asp Leu Leu Ala Gln Asp Arg Thr Pro Ile Gly
        355                 360                 365             
Asn Ser Arg Pro Ser Pro Ile Leu Glu Pro Gly Ile Gln Ser Cys Leu
    370                 375                 380                 
Thr His Phe Ser Leu Ile Thr His Gly Phe Gly Ala Pro Ala Ile Cys
385                 390                 395                 400 
Ala Ala Leu Thr Ala Leu Gln Asn Tyr Leu Thr Glu Ala Leu Lys Gly
                405                 410                 415     
Met Asp Lys Met Phe Leu Asn Asn Thr Thr Thr Asn Arg His Thr Ser
            420                 425                 430         
Gly Glu Gly Pro Gly Ser Lys Thr Gly Asp Lys Glu Glu Lys His Arg
        435                 440                 445             
Lys
    


<210> 509
<211> 254
<212> PRT
<213> Homo sapiens

<400> 509
Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro
 1               5                  10                  15      
Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val
            20                  25                  30          
Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe
        35                  40                  45              
Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser
    50                  55                  60                  
Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp
65                  70                  75                  80  
Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val
                85                  90                  95      
Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp
            100                 105                 110         
Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu
        115                 120                 125             
Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe
    130                 135                 140                 
Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser
145                 150                 155                 160 
Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala
                165                 170                 175     
Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala
            180                 185                 190         
Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala
        195                 200                 205             
Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His
    210                 215                 220                 
Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val
225                 230                 235                 240 
Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu
                245                 250                 


<210> 510
<211> 206
<212> PRT
<213> Homo sapiens

<400> 510
Met Asp Ser Ala Gly Gln Asp Ile Asn Leu Asn Ser Pro Asn Lys Gly
 1               5                  10                  15      
Leu Leu Ser Asp Ser Met Thr Asp Val Pro Val Asp Thr Gly Val Ala
            20                  25                  30          
Ala Arg Thr Pro Ala Val Glu Gly Leu Thr Glu Ala Glu Glu Glu Glu
        35                  40                  45              
Leu Arg Ala Glu Leu Thr Lys Val Glu Glu Glu Ile Val Thr Leu Arg
    50                  55                  60                  
Gln Val Leu Ala Ala Lys Glu Lys His Cys Gly Glu Leu Lys Arg Arg
65                  70                  75                  80  
Leu Gly Leu Ser Thr Leu Gly Glu Leu Lys Gln Asn Leu Ser Arg Ser
                85                  90                  95      
Trp His Asp Val Gln Val Ser Ser Ala Tyr Val Lys Thr Ser Glu Lys
            100                 105                 110         
Leu Gly Glu Trp Asn Glu Lys Val Thr Gln Ser Asp Leu Tyr Lys Lys
        115                 120                 125             
Thr Gln Glu Thr Leu Ser Gln Ala Gly Gln Lys Thr Ser Ala Ala Leu
    130                 135                 140                 
Ser Thr Val Gly Ser Ala Ile Ser Arg Lys Leu Gly Asp Met Arg Asn
145                 150                 155                 160 
Ser Ala Thr Phe Lys Ser Phe Glu Asp Arg Val Gly Thr Ile Lys Ser
                165                 170                 175     
Lys Val Val Gly Asp Arg Glu Asn Gly Ser Asp Asn Leu Pro Ser Ser
            180                 185                 190         
Ala Gly Ser Gly Asp Lys Pro Leu Ser Asp Pro Ala Pro Phe
        195                 200                 205     


<210> 511
<211> 249
<212> PRT
<213> Homo sapiens

<400> 511
Met Ala Pro Ser Arg Lys Phe Phe Val Gly Gly Asn Trp Lys Met Asn
 1               5                  10                  15      
Gly Arg Lys Gln Ser Leu Gly Glu Leu Ile Gly Thr Leu Asn Ala Ala
            20                  25                  30          
Lys Val Pro Ala Asp Thr Glu Val Val Cys Ala Pro Pro Thr Ala Tyr
        35                  40                  45              
Ile Asp Phe Ala Arg Gln Lys Leu Asp Pro Lys Ile Ala Val Ala Ala
    50                  55                  60                  
Gln Asn Cys Tyr Lys Val Thr Asn Gly Ala Phe Thr Gly Glu Ile Ser
65                  70                  75                  80  
Pro Gly Met Ile Lys Asp Cys Gly Ala Thr Trp Val Val Leu Gly His
                85                  90                  95      
Ser Glu Arg Arg His Val Phe Gly Glu Ser Asp Glu Leu Ile Gly Gln
            100                 105                 110         
Lys Val Ala His Ala Leu Ala Glu Gly Leu Gly Val Ile Ala Cys Ile
        115                 120                 125             
Gly Glu Lys Leu Asp Glu Arg Glu Ala Gly Ile Thr Glu Lys Val Val
    130                 135                 140                 
Phe Glu Gln Thr Lys Val Ile Ala Asp Asn Val Lys Asp Trp Ser Lys
145                 150                 155                 160 
Val Val Leu Ala Tyr Glu Pro Val Trp Ala Ile Gly Thr Gly Lys Thr
                165                 170                 175     
Ala Thr Pro Gln Gln Ala Gln Glu Val His Glu Lys Leu Arg Gly Trp
            180                 185                 190         
Leu Lys Ser Asn Val Ser Asp Ala Val Ala Gln Ser Thr Arg Ile Ile
        195                 200                 205             
Tyr Gly Gly Ser Val Thr Gly Ala Thr Cys Lys Glu Leu Ala Ser Gln
    210                 215                 220                 
Pro Asp Val Asp Gly Phe Leu Val Gly Gly Ala Ser Leu Lys Pro Glu
225                 230                 235                 240 
Phe Val Asp Ile Ile Asn Ala Lys Gln
                245                 


<210> 512
<211> 249
<212> PRT
<213> Homo sapiens

<400> 512
Met Ala Pro Ser Arg Lys Phe Phe Val Gly Gly Asn Trp Lys Met Asn
 1               5                  10                  15      
Gly Arg Lys Gln Ser Leu Gly Glu Leu Ile Gly Thr Leu Asn Ala Ala
            20                  25                  30          
Lys Val Pro Ala Asp Thr Glu Val Val Cys Ala Pro Pro Thr Ala Tyr
        35                  40                  45              
Ile Asp Phe Ala Arg Gln Lys Leu Asp Pro Lys Ile Ala Val Ala Ala
    50                  55                  60                  
Gln Asn Cys Tyr Lys Val Thr Asn Gly Ala Phe Thr Gly Glu Ile Ser
65                  70                  75                  80  
Pro Gly Met Ile Lys Asp Cys Gly Ala Thr Trp Val Val Leu Gly His
                85                  90                  95      
Ser Glu Arg Arg His Val Phe Gly Glu Ser Asp Glu Leu Ile Gly Gln
            100                 105                 110         
Lys Val Ala His Ala Leu Ala Glu Gly Leu Gly Val Ile Ala Cys Ile
        115                 120                 125             
Gly Glu Lys Leu Asp Glu Arg Glu Ala Gly Ile Thr Glu Lys Val Val
    130                 135                 140                 
Phe Glu Gln Thr Lys Val Ile Ala Asp Asn Val Lys Asp Trp Ser Lys
145                 150                 155                 160 
Val Val Leu Ala Tyr Glu Pro Val Trp Ala Ile Gly Thr Gly Lys Thr
                165                 170                 175     
Ala Thr Pro Gln Gln Ala Gln Glu Val His Glu Lys Leu Arg Gly Trp
            180                 185                 190         
Leu Lys Ser Asn Val Ser Asp Ala Val Ala Gln Ser Thr Arg Ile Ile
        195                 200                 205             
Tyr Gly Gly Ser Val Thr Gly Ala Thr Cys Lys Glu Leu Ala Ser Gln
    210                 215                 220                 
Pro Asp Val Asp Gly Phe Leu Val Gly Gly Ala Ser Leu Lys Pro Glu
225                 230                 235                 240 
Phe Val Asp Ile Ile Asn Ala Lys Gln
                245                 


<210> 513
<211> 370
<212> PRT
<213> Homo sapiens

<400> 513
Met Val Gly Lys Leu Lys Gln Asn Leu Leu Leu Ala Cys Leu Val Ile
 1               5                  10                  15      
Ser Ser Val Thr Val Phe Tyr Leu Gly Gln His Ala Met Glu Cys His
            20                  25                  30          
His Arg Ile Glu Glu Arg Ser Gln Pro Val Lys Leu Glu Ser Thr Arg
        35                  40                  45              
Thr Thr Val Arg Thr Gly Leu Asp Leu Lys Ala Asn Lys Thr Phe Ala
    50                  55                  60                  
Tyr His Lys Asp Met Pro Leu Ile Phe Ile Gly Gly Val Pro Arg Ser
65                  70                  75                  80  
Gly Thr Thr Leu Met Arg Ala Met Leu Asp Ala His Pro Asp Ile Arg
                85                  90                  95      
Cys Gly Glu Glu Thr Arg Val Ile Pro Arg Ile Leu Ala Leu Lys Gln
            100                 105                 110         
Met Trp Ser Arg Ser Ser Lys Glu Lys Ile Arg Leu Asp Glu Ala Gly
        115                 120                 125             
Val Thr Asp Glu Val Leu Asp Ser Ala Met Gln Ala Phe Leu Leu Glu
    130                 135                 140                 
Ile Ile Val Lys His Gly Glu Pro Ala Pro Tyr Leu Cys Asn Lys Asp
145                 150                 155                 160 
Pro Phe Ala Leu Lys Ser Leu Thr Tyr Leu Ser Arg Leu Phe Pro Asn
                165                 170                 175     
Ala Lys Phe Leu Leu Met Val Arg Asp Gly Arg Ala Ser Val His Ser
            180                 185                 190         
Met Ile Ser Arg Lys Val Thr Ile Ala Gly Phe Asp Leu Asn Ser Tyr
        195                 200                 205             
Arg Asp Cys Leu Thr Lys Trp Asn Arg Ala Ile Glu Thr Met Tyr Asn
    210                 215                 220                 
Gln Cys Met Glu Val Gly Tyr Lys Lys Cys Met Leu Val His Tyr Glu
225                 230                 235                 240 
Gln Leu Val Leu His Pro Glu Arg Trp Met Arg Thr Leu Leu Lys Phe
                245                 250                 255     
Leu Gln Ile Pro Trp Asn His Ser Val Leu His His Glu Glu Met Ile
            260                 265                 270         
Gly Lys Ala Gly Gly Val Ser Leu Ser Lys Val Glu Arg Ser Thr Asp
        275                 280                 285             
Gln Val Ile Lys Pro Val Asn Val Gly Ala Leu Ser Lys Trp Val Gly
    290                 295                 300                 
Lys Ile Pro Pro Asp Val Leu Gln Asp Met Ala Val Ile Ala Pro Met
305                 310                 315                 320 
Leu Ala Lys Leu Gly Tyr Asp Pro Tyr Ala Asn Pro Pro Asn Tyr Gly
                325                 330                 335     
Lys Pro Asp Pro Lys Ile Ile Glu Asn Thr Arg Arg Val Tyr Lys Gly
            340                 345                 350         
Glu Phe Gln Leu Pro Asp Phe Leu Lys Glu Lys Pro Gln Thr Glu Gln
        355                 360                 365             
Val Glu
    370 


<210> 514
<211> 803
<212> PRT
<213> Homo sapiens

<400> 514
Met Arg Ala Leu Trp Val Leu Gly Leu Cys Cys Val Leu Leu Thr Phe
 1               5                  10                  15      
Gly Ser Val Arg Ala Asp Asp Glu Val Asp Val Asp Gly Thr Val Glu
            20                  25                  30          
Glu Asp Leu Gly Lys Ser Arg Glu Gly Ser Arg Thr Asp Asp Glu Val
        35                  40                  45              
Val Gln Arg Glu Glu Glu Ala Ile Gln Leu Asp Gly Leu Asn Ala Ser
    50                  55                  60                  
Gln Ile Arg Glu Leu Arg Glu Lys Ser Glu Lys Phe Ala Phe Gln Ala
65                  70                  75                  80  
Glu Val Asn Arg Met Met Lys Leu Ile Ile Asn Ser Leu Tyr Lys Asn
                85                  90                  95      
Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ala Ser Asp Ala Leu
            100                 105                 110         
Asp Lys Ile Arg Leu Ile Ser Leu Thr Asp Glu Asn Ala Leu Ser Gly
        115                 120                 125             
Asn Glu Glu Leu Thr Val Lys Ile Lys Cys Asp Lys Glu Lys Asn Leu
    130                 135                 140                 
Leu His Val Thr Asp Thr Gly Val Gly Met Thr Arg Glu Glu Leu Val
145                 150                 155                 160 
Lys Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Ser Glu Phe Leu Asn
                165                 170                 175     
Lys Met Thr Glu Ala Gln Glu Asp Gly Gln Ser Thr Ser Glu Leu Ile
            180                 185                 190         
Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala Phe Leu Val Ala Asp Lys
        195                 200                 205             
Val Ile Val Thr Ser Lys His Asn Asn Asp Thr Gln His Ile Trp Glu
    210                 215                 220                 
Ser Asp Ser Asn Glu Phe Ser Val Ile Ala Asp Pro Arg Gly Asn Thr
225                 230                 235                 240 
Leu Gly Arg Gly Thr Thr Ile Thr Leu Val Leu Lys Glu Glu Ala Ser
                245                 250                 255     
Asp Tyr Leu Glu Leu Asp Thr Ile Lys Asn Leu Val Lys Lys Tyr Ser
            260                 265                 270         
Gln Phe Ile Asn Phe Pro Ile Tyr Val Trp Ser Ser Lys Thr Glu Thr
        275                 280                 285             
Val Glu Glu Pro Met Glu Glu Glu Glu Ala Ala Lys Glu Glu Lys Glu
    290                 295                 300                 
Glu Ser Asp Asp Glu Ala Ala Val Glu Glu Glu Glu Glu Glu Lys Lys
305                 310                 315                 320 
Pro Lys Thr Lys Lys Val Glu Lys Thr Val Trp Asp Trp Glu Leu Met
                325                 330                 335     
Asn Asp Ile Lys Pro Ile Trp Gln Arg Pro Ser Lys Glu Val Glu Glu
            340                 345                 350         
Asp Glu Tyr Lys Ala Phe Tyr Lys Ser Phe Ser Lys Glu Ser Asp Asp
        355                 360                 365             
Pro Met Ala Tyr Ile His Phe Thr Ala Glu Gly Glu Val Thr Phe Lys
    370                 375                 380                 
Ser Ile Leu Phe Val Pro Thr Ser Ala Pro Arg Gly Leu Phe Asp Glu
385                 390                 395                 400 
Tyr Gly Ser Lys Lys Ser Asp Tyr Ile Lys Leu Tyr Val Arg Arg Val
                405                 410                 415     
Phe Ile Thr Asp Asp Phe His Asp Met Met Pro Lys Tyr Leu Asn Phe
            420                 425                 430         
Val Lys Gly Val Val Asp Ser Asp Asp Leu Pro Leu Asn Val Ser Arg
        435                 440                 445             
Glu Thr Leu Gln Gln His Lys Leu Leu Lys Val Ile Arg Lys Lys Leu
    450                 455                 460                 
Val Arg Lys Thr Leu Asp Met Ile Lys Lys Ile Ala Asp Asp Lys Tyr
465                 470                 475                 480 
Asn Asp Thr Phe Trp Lys Glu Phe Gly Thr Asn Ile Lys Leu Gly Val
                485                 490                 495     
Ile Glu Asp His Ser Asn Arg Thr Arg Leu Ala Lys Leu Leu Arg Phe
            500                 505                 510         
Gln Ser Ser His His Pro Thr Asp Ile Thr Ser Leu Asp Gln Tyr Val
        515                 520                 525             
Glu Arg Met Lys Glu Lys Gln Asp Lys Ile Tyr Phe Met Ala Gly Ser
    530                 535                 540                 
Ser Arg Lys Glu Ala Glu Ser Ser Pro Phe Val Glu Arg Leu Leu Lys
545                 550                 555                 560 
Lys Gly Tyr Glu Val Ile Tyr Leu Thr Glu Pro Val Asp Glu Tyr Cys
                565                 570                 575     
Ile Gln Ala Leu Pro Glu Phe Asp Gly Lys Arg Phe Gln Asn Val Ala
            580                 585                 590         
Lys Glu Gly Val Lys Phe Asp Glu Ser Glu Lys Thr Lys Glu Ser Arg
        595                 600                 605             
Glu Ala Val Glu Lys Glu Phe Glu Pro Leu Leu Asn Trp Met Lys Asp
    610                 615                 620                 
Lys Ala Leu Lys Asp Lys Ile Glu Lys Ala Val Val Ser Gln Arg Leu
625                 630                 635                 640 
Thr Glu Ser Pro Cys Ala Leu Val Ala Ser Gln Tyr Gly Trp Ser Gly
                645                 650                 655     
Asn Met Glu Arg Ile Met Lys Ala Gln Ala Tyr Gln Thr Gly Lys Asp
            660                 665                 670         
Ile Ser Thr Asn Tyr Tyr Ala Ser Gln Lys Lys Thr Phe Glu Ile Asn
        675                 680                 685             
Pro Arg His Pro Leu Ile Arg Asp Met Leu Arg Arg Ile Lys Glu Asp
    690                 695                 700                 
Glu Asp Asp Lys Thr Val Leu Asp Leu Ala Val Val Leu Phe Glu Thr
705                 710                 715                 720 
Ala Thr Leu Arg Ser Gly Tyr Leu Leu Pro Asp Thr Lys Ala Tyr Gly
                725                 730                 735     
Asp Arg Ile Glu Arg Met Leu Arg Leu Ser Leu Asn Ile Asp Pro Asp
            740                 745                 750         
Ala Lys Val Glu Glu Glu Pro Glu Glu Glu Pro Glu Glu Thr Ala Glu
        755                 760                 765             
Asp Thr Thr Glu Asp Thr Glu Gln Asp Glu Asp Glu Glu Met Asp Val
    770                 775                 780                 
Gly Thr Asp Glu Glu Glu Glu Thr Ala Lys Glu Ser Thr Ala Glu Lys
785                 790                 795                 800 
Asp Glu Leu
            


<210> 515
<211> 484
<212> PRT
<213> Homo sapiens

<400> 515
Met Ala Ala Thr Glu Pro Glu Leu Leu Asp Asp Gln Glu Ala Lys Arg
 1               5                  10                  15      
Glu Ala Glu Thr Phe Lys Glu Gln Gly Asn Ala Tyr Tyr Ala Lys Lys
            20                  25                  30          
Asp Tyr Asn Glu Ala Tyr Asn Tyr Tyr Thr Lys Ala Ile Asp Met Cys
        35                  40                  45              
Pro Lys Asn Ala Ser Tyr Tyr Gly Asn Arg Ala Ala Thr Leu Met Met
    50                  55                  60                  
Leu Gly Arg Phe Arg Glu Ala Leu Gly Asp Ala Gln Gln Ser Val Arg
65                  70                  75                  80  
Leu Asp Asp Ser Phe Val Arg Gly His Leu Arg Glu Gly Lys Cys His
                85                  90                  95      
Leu Ser Leu Gly Asn Ala Met Ala Ala Cys Arg Ser Phe Gln Arg Ala
            100                 105                 110         
Leu Glu Leu Asp His Lys Asn Ala Gln Ala Gln Gln Glu Phe Lys Asn
        115                 120                 125             
Ala Asn Ala Val Met Glu Tyr Glu Lys Ile Ala Glu Thr Asp Phe Glu
    130                 135                 140                 
Lys Arg Asp Phe Arg Lys Val Val Phe Cys Met Asp Arg Ala Leu Glu
145                 150                 155                 160 
Phe Ala Pro Ala Cys His Arg Phe Lys Ile Leu Lys Ala Glu Cys Leu
                165                 170                 175     
Ala Met Leu Gly Arg Tyr Pro Glu Ala Gln Ser Val Ala Ser Asp Ile
            180                 185                 190         
Leu Arg Met Asp Ser Thr Asn Ala Asp Ala Leu Tyr Val Arg Gly Leu
        195                 200                 205             
Cys Leu Tyr Tyr Glu Asp Cys Ile Glu Lys Ala Val Gln Phe Phe Val
    210                 215                 220                 
Gln Ala Leu Arg Met Ala Pro Asp His Glu Lys Ala Cys Ile Ala Cys
225                 230                 235                 240 
Arg Asn Ala Lys Ala Leu Lys Ala Lys Lys Glu Asp Gly Asn Lys Ala
                245                 250                 255     
Phe Lys Glu Gly Asn Tyr Lys Leu Ala Tyr Glu Leu Tyr Thr Glu Ala
            260                 265                 270         
Leu Gly Ile Asp Pro Asn Asn Ile Lys Thr Asn Ala Lys Leu Tyr Cys
        275                 280                 285             
Asn Arg Gly Thr Val Asn Ser Lys Leu Arg Lys Leu Asp Asp Ala Ile
    290                 295                 300                 
Glu Asp Cys Thr Asn Ala Val Lys Leu Asp Asp Thr Tyr Ile Lys Ala
305                 310                 315                 320 
Tyr Leu Arg Arg Ala Gln Cys Tyr Met Asp Thr Glu Gln Tyr Glu Glu
                325                 330                 335     
Ala Val Arg Asp Tyr Glu Lys Val Tyr Gln Thr Glu Lys Thr Lys Glu
            340                 345                 350         
His Lys Gln Leu Leu Lys Asn Ala Gln Leu Glu Leu Lys Lys Ser Lys
        355                 360                 365             
Arg Lys Asp Tyr Tyr Lys Ile Leu Gly Val Asp Lys Asn Ala Ser Glu
    370                 375                 380                 
Asp Glu Ile Lys Lys Ala Tyr Arg Lys Arg Ala Leu Met His His Pro
385                 390                 395                 400 
Asp Arg His Ser Gly Ala Ser Ala Glu Val Gln Lys Glu Glu Glu Lys
                405                 410                 415     
Lys Phe Lys Glu Val Gly Glu Ala Phe Thr Ile Leu Ser Asp Pro Lys
            420                 425                 430         
Lys Lys Thr Arg Tyr Asp Ser Gly Gln Asp Leu Asp Glu Glu Gly Met
        435                 440                 445             
Asn Met Gly Asp Phe Asp Pro Asn Asn Ile Phe Lys Ala Phe Phe Gly
    450                 455                 460                 
Gly Pro Gly Gly Phe Ser Phe Glu Ala Ser Gly Pro Gly Asn Phe Phe
465                 470                 475                 480 
Phe Gln Phe Gly
                


<210> 516
<211> 452
<212> PRT
<213> Homo sapiens

<400> 516
Met Ala Ala Ala Thr Leu Leu Arg Ala Thr Pro His Phe Ser Gly Leu
 1               5                  10                  15      
Ala Ala Gly Arg Thr Phe Leu Leu Gln Gly Leu Leu Arg Leu Leu Lys
            20                  25                  30          
Ala Pro Ala Leu Pro Leu Leu Cys Arg Gly Leu Ala Val Glu Ala Lys
        35                  40                  45              
Lys Thr Tyr Val Arg Asp Lys Pro His Val Asn Val Gly Thr Ile Gly
    50                  55                  60                  
His Val Asp His Gly Lys Thr Thr Leu Thr Ala Ala Ile Thr Lys Ile
65                  70                  75                  80  
Leu Ala Glu Gly Gly Gly Ala Lys Phe Lys Lys Tyr Glu Glu Ile Asp
                85                  90                  95      
Asn Ala Pro Glu Glu Arg Ala Arg Gly Ile Thr Ile Asn Ala Ala His
            100                 105                 110         
Val Glu Tyr Ser Thr Ala Ala Arg His Tyr Ala His Thr Asp Cys Pro
        115                 120                 125             
Gly His Ala Asp Tyr Val Lys Asn Met Ile Thr Gly Thr Ala Pro Leu
    130                 135                 140                 
Asp Gly Cys Ile Leu Val Val Ala Ala Asn Asp Gly Pro Met Pro Gln
145                 150                 155                 160 
Thr Arg Glu His Leu Leu Leu Ala Arg Gln Ile Gly Val Glu His Val
                165                 170                 175     
Val Val Tyr Val Asn Lys Ala Asp Ala Val Gln Asp Ser Glu Met Val
            180                 185                 190         
Glu Leu Val Glu Leu Glu Ile Arg Glu Leu Leu Thr Glu Phe Gly Tyr
        195                 200                 205             
Lys Gly Glu Glu Thr Pro Val Ile Val Gly Ser Ala Leu Cys Ala Leu
    210                 215                 220                 
Glu Gly Arg Asp Pro Glu Leu Gly Leu Lys Ser Val Gln Lys Leu Leu
225                 230                 235                 240 
Asp Ala Val Asp Thr Tyr Ile Pro Val Pro Ala Arg Asp Leu Glu Lys
                245                 250                 255     
Pro Phe Leu Leu Pro Val Glu Ala Val Tyr Ser Val Pro Gly Arg Gly
            260                 265                 270         
Thr Val Val Thr Gly Thr Leu Glu Arg Gly Ile Leu Lys Lys Gly Asp
        275                 280                 285             
Glu Cys Glu Leu Leu Gly His Ser Lys Asn Ile Arg Thr Val Val Thr
    290                 295                 300                 
Gly Ile Glu Met Phe His Lys Ser Leu Glu Arg Ala Glu Ala Gly Asp
305                 310                 315                 320 
Asn Leu Gly Ala Leu Val Arg Gly Leu Lys Arg Glu Asp Leu Arg Arg
                325                 330                 335     
Gly Leu Val Met Val Lys Pro Gly Ser Ile Lys Pro His Gln Lys Val
            340                 345                 350         
Glu Ala Gln Val Tyr Ile Leu Ser Lys Glu Glu Gly Gly Arg His Lys
        355                 360                 365             
Pro Phe Val Ser His Phe Met Pro Val Met Phe Ser Leu Thr Trp Asn
    370                 375                 380                 
Met Ala Cys Arg Ile Ile Leu Pro Pro Glu Lys Glu Leu Ala Met Pro
385                 390                 395                 400 
Gly Glu Asp Leu Lys Phe Asn Leu Ile Leu Arg Gln Pro Met Ile Leu
                405                 410                 415     
Glu Lys Gly Gln Arg Phe Thr Leu Arg Asp Gly Asn Arg Thr Ile Gly
            420                 425                 430         
Thr Gly Leu Val Thr Asn Thr Leu Ala Met Thr Glu Glu Glu Lys Asn
        435                 440                 445             
Ile Lys Trp Gly
    450         


<210> 517
<211> 183
<212> PRT
<213> Homo sapiens

<400> 517
Met Ser Ser Pro Ser Pro Gly Lys Arg Arg Met Asp Thr Asp Val Val
 1               5                  10                  15      
Lys Leu Ile Glu Ser Lys His Glu Val Thr Ile Leu Gly Gly Leu Asn
            20                  25                  30          
Glu Phe Val Val Lys Phe Tyr Gly Pro Gln Gly Thr Pro Tyr Glu Gly
        35                  40                  45              
Gly Val Trp Lys Val Arg Val Asp Leu Pro Asp Lys Tyr Pro Phe Lys
    50                  55                  60                  
Ser Pro Ser Ile Gly Phe Met Asn Lys Ile Phe His Pro Asn Ile Asp
65                  70                  75                  80  
Glu Ala Ser Gly Thr Val Cys Leu Asp Val Ile Asn Gln Thr Trp Thr
                85                  90                  95      
Ala Leu Tyr Asp Leu Thr Asn Ile Phe Glu Ser Phe Leu Pro Gln Leu
            100                 105                 110         
Leu Ala Tyr Pro Asn Pro Ile Asp Pro Leu Asn Gly Asp Ala Ala Ala
        115                 120                 125             
Met Tyr Leu His Arg Pro Glu Glu Tyr Lys Gln Lys Ile Lys Glu Tyr
    130                 135                 140                 
Ile Gln Lys Tyr Ala Thr Glu Glu Ala Leu Lys Glu Gln Glu Glu Gly
145                 150                 155                 160 
Thr Gly Asp Ser Ser Ser Glu Ser Ser Met Ser Asp Phe Ser Glu Asp
                165                 170                 175     
Glu Ala Gln Asp Met Glu Leu
            180             


<210> 518
<211> 154
<212> PRT
<213> Homo sapiens

<400> 518
Met Ala Ala Ser Arg Arg Leu Met Lys Glu Leu Glu Glu Ile Arg Lys
 1               5                  10                  15      
Cys Gly Met Lys Asn Phe Arg Asn Ile Gln Val Asp Glu Ala Asn Leu
            20                  25                  30          
Leu Thr Trp Gln Gly Leu Ile Val Pro Asp Asn Pro Pro Tyr Asp Lys
        35                  40                  45              
Gly Ala Phe Arg Ile Glu Ile Asn Phe Pro Ala Glu Tyr Pro Phe Lys
    50                  55                  60                  
Pro Pro Lys Ile Thr Phe Lys Thr Lys Ile Tyr His Pro Asn Ile Asp
65                  70                  75                  80  
Glu Lys Gly Gln Val Cys Leu Pro Val Ile Ser Ala Glu Asn Trp Lys
                85                  90                  95      
Pro Ala Thr Lys Thr Asp Gln Val Ile Gln Ser Leu Ile Ala Leu Val
            100                 105                 110         
Asn Asp Pro Gln Pro Glu His Pro Leu Arg Ala Asp Leu Ala Glu Glu
        115                 120                 125             
Tyr Ser Lys Asp Arg Lys Lys Phe Cys Lys Asn Ala Glu Glu Phe Thr
    130                 135                 140                 
Lys Lys Tyr Gly Glu Lys Arg Pro Val Asp
145                 150                 


<210> 519
<211> 152
<212> PRT
<213> Homo sapiens

<400> 519
Met Ala Gly Leu Pro Arg Arg Ile Ile Lys Glu Thr Gln Arg Leu Leu
 1               5                  10                  15      
Ala Glu Pro Val Pro Gly Ile Lys Ala Glu Pro Asp Glu Ser Asn Ala
            20                  25                  30          
Arg Tyr Phe His Val Val Ile Ala Gly Pro Gln Asp Ser Pro Phe Glu
        35                  40                  45              
Gly Gly Thr Phe Lys Leu Glu Leu Phe Leu Pro Glu Glu Tyr Pro Met
    50                  55                  60                  
Ala Ala Pro Lys Val Arg Phe Met Thr Lys Ile Tyr His Pro Asn Val
65                  70                  75                  80  
Asp Lys Leu Gly Arg Ile Cys Leu Asp Ile Leu Lys Asp Lys Trp Ser
                85                  90                  95      
Pro Ala Leu Gln Ile Arg Thr Val Leu Leu Ser Ile Gln Ala Leu Leu
            100                 105                 110         
Ser Ala Pro Asn Pro Asp Asp Pro Leu Ala Asn Asp Val Ala Glu Gln
        115                 120                 125             
Trp Lys Thr Asn Glu Ala Gln Ala Ile Glu Thr Ala Arg Ala Trp Thr
    130                 135                 140                 
Arg Leu Tyr Ala Met Asn Asn Ile
145                 150         


<210> 520
<211> 480
<212> PRT
<213> Homo sapiens

<400> 520
Met Ala Ala Ser Val Val Cys Arg Ala Ala Thr Ala Gly Ala Gln Val
 1               5                  10                  15      
Leu Leu Arg Ala Arg Arg Ser Pro Ala Leu Leu Arg Thr Pro Ala Leu
            20                  25                  30          
Arg Ser Thr Ala Thr Phe Ala Gln Ala Leu Gln Phe Val Pro Glu Thr
        35                  40                  45              
Gln Val Ser Leu Leu Asp Asn Gly Leu Arg Val Ala Ser Glu Gln Ser
    50                  55                  60                  
Ser Gln Pro Thr Cys Thr Val Gly Val Trp Ile Asp Val Gly Ser Arg
65                  70                  75                  80  
Phe Glu Thr Glu Lys Asn Asn Gly Ala Gly Tyr Phe Leu Glu His Leu
                85                  90                  95      
Ala Phe Lys Gly Thr Lys Asn Arg Pro Gly Ser Ala Leu Glu Lys Glu
            100                 105                 110         
Val Glu Ser Met Gly Ala His Leu Asn Ala Tyr Ser Thr Arg Glu His
        115                 120                 125             
Thr Ala Tyr Tyr Ile Lys Ala Leu Ser Lys Asp Leu Pro Lys Ala Val
    130                 135                 140                 
Glu Leu Leu Gly Asp Ile Val Gln Asn Cys Ser Leu Glu Asp Ser Gln
145                 150                 155                 160 
Ile Glu Lys Glu Arg Asp Val Ile Leu Arg Glu Met Gln Glu Asn Asp
                165                 170                 175     
Ala Ser Met Arg Asp Val Val Phe Asn Tyr Leu His Ala Thr Ala Phe
            180                 185                 190         
Gln Gly Thr Pro Leu Ala Gln Ala Val Glu Gly Pro Ser Glu Asn Val
        195                 200                 205             
Arg Lys Leu Ser Arg Ala Asp Leu Thr Glu Tyr Leu Ser Thr His Tyr
    210                 215                 220                 
Lys Ala Pro Arg Met Val Leu Ala Ala Ala Gly Gly Val Glu His Gln
225                 230                 235                 240 
Gln Leu Leu Asp Leu Ala Gln Lys His Leu Gly Gly Ile Pro Trp Thr
                245                 250                 255     
Tyr Ala Glu Asp Ala Val Pro Thr Leu Thr Pro Cys Arg Phe Thr Gly
            260                 265                 270         
Ser Glu Ile Arg His Arg Asp Asp Ala Leu Pro Phe Ala His Val Ala
        275                 280                 285             
Ile Ala Val Glu Gly Pro Gly Trp Ala Ser Pro Asp Ser Val Ala Leu
    290                 295                 300                 
Gln Val Ala Asn Ala Ile Ile Gly His Tyr Asp Cys Thr Tyr Gly Gly
305                 310                 315                 320 
Gly Val His Leu Ser Ser Pro Leu Ala Ser Gly Ala Val Ala Asn Lys
                325                 330                 335     
Leu Cys Gln Ser Phe Gln Thr Phe Ser Ile Cys Tyr Ala Glu Thr Gly
            340                 345                 350         
Leu Leu Gly Ala His Phe Val Cys Asp Arg Met Lys Ile Asp Asp Met
        355                 360                 365             
Met Phe Val Leu Gln Gly Gln Trp Met Arg Leu Cys Thr Ser Ala Thr
    370                 375                 380                 
Glu Ser Glu Val Ala Arg Gly Lys Asn Ile Leu Arg Asn Ala Leu Val
385                 390                 395                 400 
Ser His Leu Asp Gly Thr Thr Pro Val Cys Glu Asp Ile Gly Arg Ser
                405                 410                 415     
Leu Leu Thr Tyr Gly Arg Arg Ile Pro Leu Ala Glu Trp Glu Ser Arg
            420                 425                 430         
Ile Ala Glu Val Asp Ala Ser Val Val Arg Glu Ile Cys Ser Lys Tyr
        435                 440                 445             
Ile Tyr Asp Gln Cys Pro Ala Val Ala Gly Tyr Gly Pro Ile Glu Gln
    450                 455                 460                 
Leu Pro Asp Tyr Asn Arg Ile Arg Ser Gly Met Phe Trp Leu Arg Phe
465                 470                 475                 480 


<210> 521
<211> 453
<212> PRT
<213> Homo sapiens

<400> 521
Met Lys Leu Leu Thr Arg Ala Gly Ser Phe Ser Arg Phe Tyr Ser Leu
 1               5                  10                  15      
Lys Val Ala Pro Lys Val Lys Ala Thr Ala Ala Pro Ala Gly Ala Pro
            20                  25                  30          
Pro Gln Pro Gln Asp Leu Glu Phe Thr Lys Leu Pro Asn Gly Leu Val
        35                  40                  45              
Ile Ala Ser Leu Glu Asn Tyr Ser Pro Val Ser Arg Ile Gly Leu Phe
    50                  55                  60                  
Ile Lys Ala Gly Ser Arg Tyr Glu Asp Phe Ser Asn Leu Gly Thr Thr
65                  70                  75                  80  
His Leu Leu Arg Leu Thr Ser Ser Leu Thr Thr Lys Gly Ala Ser Ser
                85                  90                  95      
Phe Lys Ile Thr Arg Gly Ile Glu Ala Val Gly Gly Lys Leu Ser Val
            100                 105                 110         
Thr Ala Thr Arg Glu Asn Met Ala Tyr Thr Val Glu Cys Leu Arg Gly
        115                 120                 125             
Asp Val Asp Ile Leu Met Glu Phe Leu Leu Asn Val Thr Thr Ala Pro
    130                 135                 140                 
Glu Phe Arg Arg Trp Glu Val Ala Asp Leu Gln Pro Gln Leu Lys Ile
145                 150                 155                 160 
Asp Lys Ala Val Ala Phe Gln Asn Pro Gln Thr His Val Ile Glu Asn
                165                 170                 175     
Leu His Ala Ala Ala Tyr Gln Asn Ala Leu Ala Asn Pro Leu Tyr Cys
            180                 185                 190         
Pro Asp Tyr Arg Ile Gly Lys Val Thr Ser Glu Glu Leu His Tyr Phe
        195                 200                 205             
Val Gln Asn His Phe Thr Ser Ala Arg Met Ala Leu Ile Gly Leu Gly
    210                 215                 220                 
Val Ser His Pro Val Leu Lys Gln Val Ala Glu Gln Phe Leu Asn Met
225                 230                 235                 240 
Arg Gly Gly Leu Gly Leu Ser Gly Ala Lys Ala Asn Tyr Arg Gly Gly
                245                 250                 255     
Glu Ile Arg Glu Gln Asn Gly Asp Ser Leu Val His Ala Ala Phe Val
            260                 265                 270         
Ala Glu Ser Ala Val Ala Gly Ser Ala Glu Ala Asn Ala Phe Ser Val
        275                 280                 285             
Leu Gln His Val Leu Gly Ala Gly Pro His Val Lys Arg Gly Ser Asn
    290                 295                 300                 
Thr Thr Ser His Leu His Gln Ala Val Ala Lys Ala Thr Gln Gln Pro
305                 310                 315                 320 
Phe Asp Val Ser Ala Phe Asn Ala Ser Tyr Ser Asp Ser Gly Leu Phe
                325                 330                 335     
Gly Ile Tyr Thr Ile Ser Gln Ala Thr Ala Ala Gly Asp Val Ile Lys
            340                 345                 350         
Ala Ala Tyr Asn Gln Val Lys Arg Ile Ala Gln Gly Asn Leu Ser Asn
        355                 360                 365             
Thr Asp Val Gln Ala Ala Lys Asn Lys Leu Lys Ala Gly Tyr Leu Met
    370                 375                 380                 
Ser Val Glu Ser Ser Glu Cys Phe Leu Glu Glu Val Gly Ser Gln Ala
385                 390                 395                 400 
Leu Val Ala Gly Ser Tyr Met Pro Pro Ser Thr Val Leu Gln Gln Ile
                405                 410                 415     
Asp Ser Val Ala Asn Ala Asp Ile Ile Asn Ala Ala Lys Lys Phe Val
            420                 425                 430         
Ser Gly Gln Lys Ser Met Ala Ala Ser Gly Asn Leu Gly His Thr Pro
        435                 440                 445             
Phe Val Asp Glu Leu
    450             


<210> 522
<211> 963
<212> PRT
<213> Homo sapiens

<400> 522
Met Ala Glu Gly Gly Gly Cys Arg Glu Arg Pro Asp Ala Glu Thr Gln
 1               5                  10                  15      
Lys Ser Glu Leu Gly Pro Leu Met Arg Thr Thr Leu Gln Arg Gly Ala
            20                  25                  30          
Gln Trp Tyr Leu Ile Asp Ser Arg Trp Phe Lys Gln Trp Lys Lys Tyr
        35                  40                  45              
Val Gly Phe Asp Ser Trp Asp Met Tyr Asn Val Gly Glu His Asn Leu
    50                  55                  60                  
Phe Pro Gly Pro Ile Asp Asn Ser Gly Leu Phe Ser Asp Pro Glu Ser
65                  70                  75                  80  
Gln Thr Leu Lys Glu His Leu Ile Asp Glu Leu Asp Tyr Val Leu Val
                85                  90                  95      
Pro Thr Glu Ala Trp Asn Lys Leu Leu Asn Trp Tyr Gly Cys Val Glu
            100                 105                 110         
Gly Gln Gln Pro Ile Val Arg Lys Val Val Glu His Gly Leu Phe Val
        115                 120                 125             
Lys His Cys Lys Val Glu Val Tyr Leu Leu Glu Leu Lys Leu Cys Glu
    130                 135                 140                 
Asn Ser Asp Pro Thr Asn Val Leu Ser Cys His Phe Ser Lys Ala Asp
145                 150                 155                 160 
Thr Ile Ala Thr Ile Glu Lys Glu Met Arg Lys Leu Phe Asn Ile Pro
                165                 170                 175     
Ala Glu Arg Glu Thr Arg Leu Trp Asn Lys Tyr Met Ser Asn Thr Tyr
            180                 185                 190         
Glu Gln Leu Ser Lys Leu Asp Asn Thr Val Gln Asp Ala Gly Leu Tyr
        195                 200                 205             
Gln Gly Gln Val Leu Val Ile Glu Pro Gln Asn Glu Asp Gly Thr Trp
    210                 215                 220                 
Pro Arg Gln Thr Leu Gln Ser Lys Ser Ser Thr Ala Pro Ser Arg Asn
225                 230                 235                 240 
Phe Thr Thr Ser Pro Lys Ser Ser Ala Ser Pro Tyr Ser Ser Val Ser
                245                 250                 255     
Ala Ser Leu Ile Ala Asn Gly Asp Ser Thr Ser Thr Cys Gly Met His
            260                 265                 270         
Ser Ser Gly Val Ser Arg Gly Gly Ser Gly Phe Ser Ala Ser Tyr Asn
        275                 280                 285             
Cys Gln Glu Pro Pro Ser Ser His Ile Gln Pro Gly Leu Cys Gly Leu
    290                 295                 300                 
Gly Asn Leu Gly Asn Thr Cys Phe Met Asn Ser Ala Leu Gln Cys Leu
305                 310                 315                 320 
Ser Asn Thr Ala Pro Leu Thr Asp Tyr Phe Leu Lys Asp Glu Tyr Glu
                325                 330                 335     
Ala Glu Ile Asn Arg Asp Asn Pro Leu Gly Met Lys Gly Glu Ile Ala
            340                 345                 350         
Glu Ala Tyr Ala Glu Leu Ile Lys Gln Met Trp Ser Gly Arg Asp Ala
        355                 360                 365             
His Val Ala Pro Ser Met Phe Lys Thr Gln Val Gly Arg Phe Ala Pro
    370                 375                 380                 
Gln Phe Ser Gly Tyr Gln Gln Gln Asp Ser Gln Glu Leu Leu Ala Phe
385                 390                 395                 400 
Leu Leu Asp Gly Leu His Glu Asp Leu Asn Arg Val Lys Lys Lys Pro
                405                 410                 415     
Tyr Leu Glu Leu Lys Asp Ala Asn Gly Arg Pro Asp Ala Val Val Ala
            420                 425                 430         
Lys Glu Ala Trp Glu Asn His Arg Leu Arg Asn Asp Ser Val Ile Val
        435                 440                 445             
Asp Thr Phe His Gly Leu Phe Lys Ser Thr Leu Val Cys Pro Glu Cys
    450                 455                 460                 
Ala Lys Val Ser Val Thr Phe Asp Pro Phe Cys Tyr Leu Thr Leu Pro
465                 470                 475                 480 
Leu Pro Leu Lys Lys Asp Arg Val Met Glu Val Phe Leu Val Pro Ala
                485                 490                 495     
Asp Pro His Cys Arg Pro Thr Gln Tyr Arg Val Thr Val Pro Leu Met
            500                 505                 510         
Gly Ala Val Ser Asp Leu Cys Glu Ala Leu Ser Arg Leu Ser Gly Ile
        515                 520                 525             
Ala Ala Glu Asn Met Val Val Ala Asp Val Tyr Asn His Arg Phe His
    530                 535                 540                 
Lys Ile Phe Gln Met Asp Glu Gly Leu Asn His Ile Met Pro Arg Asp
545                 550                 555                 560 
Asp Ile Phe Val Tyr Glu Val Cys Ser Thr Ser Val Asp Gly Ser Glu
                565                 570                 575     
Cys Val Thr Leu Pro Val Tyr Phe Arg Glu Arg Lys Ser Arg Pro Ser
            580                 585                 590         
Ser Thr Ser Ser Ala Ser Ala Leu Tyr Gly Gln Pro Leu Leu Leu Ser
        595                 600                 605             
Val Pro Lys His Lys Leu Thr Leu Glu Ser Leu Tyr Gln Ala Val Cys
    610                 615                 620                 
Asp Arg Ile Ser Arg Tyr Val Lys Gln Pro Leu Pro Asp Glu Phe Gly
625                 630                 635                 640 
Ser Ser Pro Leu Glu Pro Gly Ala Cys Asn Gly Ser Arg Asn Ser Cys
                645                 650                 655     
Glu Gly Glu Asp Glu Glu Glu Met Glu His Gln Glu Glu Gly Lys Glu
            660                 665                 670         
Gln Leu Ser Glu Thr Glu Gly Ser Gly Glu Asp Glu Pro Gly Asn Asp
        675                 680                 685             
Pro Ser Glu Thr Thr Gln Lys Lys Ile Lys Gly Gln Pro Cys Pro Lys
    690                 695                 700                 
Arg Leu Phe Thr Phe Ser Leu Val Asn Ser Tyr Gly Thr Ala Asp Ile
705                 710                 715                 720 
Asn Ser Leu Ala Ala Asp Gly Lys Leu Leu Lys Leu Asn Ser Arg Ser
                725                 730                 735     
Thr Leu Ala Met Asp Trp Asp Arg Glu Thr Arg Arg Leu Tyr Tyr Asp
            740                 745                 750         
Glu Gln Glu Ser Glu Ala Tyr Glu Lys His Val Ser Met Leu Gln Pro
        755                 760                 765             
Gln Lys Lys Lys Lys Thr Thr Val Ala Leu Arg Asp Cys Ile Glu Leu
    770                 775                 780                 
Phe Thr Thr Met Glu Thr Leu Gly Glu His Asp Pro Trp Tyr Cys Pro
785                 790                 795                 800 
Asn Cys Lys Lys His Gln Gln Ala Thr Lys Lys Phe Asp Leu Trp Ser
                805                 810                 815     
Leu Pro Lys Ile Leu Val Val His Leu Lys Arg Phe Ser Tyr Asn Arg
            820                 825                 830         
Tyr Trp Arg Asp Lys Leu Asp Thr Val Val Glu Phe Pro Ile Arg Gly
        835                 840                 845             
Leu Asn Met Ser Glu Phe Val Cys Asn Leu Ser Ala Arg Pro Tyr Val
    850                 855                 860                 
Tyr Asp Leu Ile Ala Val Ser Asn His Tyr Gly Ala Met Gly Val Gly
865                 870                 875                 880 
His Tyr Thr Ala Tyr Ala Lys Asn Lys Leu Asn Gly Lys Trp Tyr Tyr
                885                 890                 895     
Phe Asp Asp Ser Asn Val Ser Leu Ala Ser Glu Asp Gln Ile Val Thr
            900                 905                 910         
Lys Ala Ala Tyr Val Leu Phe Tyr Gln Arg Arg Asp Asp Glu Phe Tyr
        915                 920                 925             
Lys Thr Pro Ser Leu Ser Ser Ser Gly Ser Ser Asp Gly Gly Thr Arg
    930                 935                 940                 
Pro Ser Ser Ser Gln Gln Gly Phe Gly Asp Asp Glu Ala Cys Ser Met
945                 950                 955                 960 
Asp Thr Asn
            


<210> 523
<211> 1102
<212> PRT
<213> Homo sapiens

<400> 523
Met Asn His Gln Gln Gln Gln Gln Gln Gln Lys Ala Gly Glu Gln Gln
 1               5                  10                  15      
Leu Ser Glu Pro Glu Asp Met Glu Met Glu Ala Gly Asp Thr Asp Asp
            20                  25                  30          
Pro Pro Arg Ile Thr Gln Asn Pro Val Ile Asn Gly Asn Val Ala Leu
        35                  40                  45              
Ser Asp Gly His Asn Thr Ala Glu Glu Asp Met Glu Asp Asp Thr Ser
    50                  55                  60                  
Trp Arg Ser Glu Ala Thr Phe Gln Phe Thr Val Glu Arg Phe Ser Arg
65                  70                  75                  80  
Leu Ser Glu Ser Val Leu Ser Pro Pro Cys Phe Val Arg Asn Leu Pro
                85                  90                  95      
Trp Lys Ile Met Val Met Pro Arg Phe Tyr Pro Asp Arg Pro His Gln
            100                 105                 110         
Lys Ser Val Gly Phe Phe Leu Gln Cys Asn Ala Glu Ser Asp Ser Thr
        115                 120                 125             
Ser Trp Ser Cys His Ala Gln Ala Val Leu Lys Ile Ile Asn Tyr Arg
    130                 135                 140                 
Asp Asp Glu Lys Ser Phe Ser Arg Arg Ile Ser His Leu Phe Phe His
145                 150                 155                 160 
Lys Glu Asn Asp Trp Gly Phe Ser Asn Phe Met Ala Trp Ser Glu Val
                165                 170                 175     
Thr Asp Pro Glu Lys Gly Phe Ile Asp Asp Asp Lys Val Thr Phe Glu
            180                 185                 190         
Val Phe Val Gln Ala Asp Ala Pro His Gly Val Ala Trp Asp Ser Lys
        195                 200                 205             
Lys His Thr Gly Tyr Val Gly Leu Lys Asn Gln Gly Ala Thr Cys Tyr
    210                 215                 220                 
Met Asn Ser Leu Leu Gln Thr Leu Phe Phe Thr Asn Gln Leu Arg Lys
225                 230                 235                 240 
Ala Val Tyr Met Met Pro Thr Glu Gly Asp Asp Ser Ser Lys Ser Val
                245                 250                 255     
Pro Leu Ala Leu Gln Arg Val Phe Tyr Glu Leu Gln His Ser Asp Lys
            260                 265                 270         
Pro Val Gly Thr Lys Lys Leu Thr Lys Ser Phe Gly Trp Glu Thr Leu
        275                 280                 285             
Asp Ser Phe Met Gln His Asp Val Gln Glu Leu Cys Arg Val Leu Leu
    290                 295                 300                 
Asp Asn Val Glu Asn Lys Met Lys Gly Thr Cys Val Glu Gly Thr Ile
305                 310                 315                 320 
Pro Lys Leu Phe Arg Gly Lys Met Val Ser Tyr Ile Gln Cys Lys Glu
                325                 330                 335     
Val Asp Tyr Arg Ser Asp Arg Arg Glu Asp Tyr Tyr Asp Ile Gln Leu
            340                 345                 350         
Ser Ile Lys Gly Lys Lys Asn Ile Phe Glu Ser Phe Val Asp Tyr Val
        355                 360                 365             
Ala Val Glu Gln Leu Asp Gly Asp Asn Lys Tyr Asp Ala Gly Glu His
    370                 375                 380                 
Gly Leu Gln Glu Ala Glu Lys Gly Val Lys Phe Leu Thr Leu Pro Pro
385                 390                 395                 400 
Val Leu His Leu Gln Leu Met Arg Phe Met Tyr Asp Pro Gln Thr Asp
                405                 410                 415     
Gln Asn Ile Lys Ile Asn Asp Arg Phe Glu Phe Pro Glu Gln Leu Pro
            420                 425                 430         
Leu Asp Glu Phe Leu Gln Lys Thr Asp Pro Lys Asp Pro Ala Asn Tyr
        435                 440                 445             
Ile Leu His Ala Val Leu Val His Ser Gly Asp Asn His Gly Gly His
    450                 455                 460                 
Tyr Val Val Tyr Leu Asn Pro Lys Gly Asp Gly Lys Trp Cys Lys Phe
465                 470                 475                 480 
Asp Asp Asp Val Val Ser Arg Cys Thr Lys Glu Glu Ala Ile Glu His
                485                 490                 495     
Asn Tyr Gly Gly His Asp Asp Asp Leu Ser Val Arg His Cys Thr Asn
            500                 505                 510         
Ala Tyr Met Leu Val Tyr Ile Arg Glu Ser Lys Leu Ser Glu Val Leu
        515                 520                 525             
Gln Ala Val Thr Asp His Asp Ile Pro Gln Gln Leu Val Glu Arg Leu
    530                 535                 540                 
Gln Glu Glu Lys Arg Ile Glu Ala Gln Lys Arg Lys Glu Arg Gln Glu
545                 550                 555                 560 
Ala His Leu Tyr Met Gln Val Gln Ile Val Ala Glu Asp Gln Phe Cys
                565                 570                 575     
Gly His Gln Gly Asn Asp Met Tyr Asp Glu Glu Lys Val Lys Tyr Thr
            580                 585                 590         
Val Phe Lys Val Leu Lys Asn Ser Ser Leu Ala Glu Phe Val Gln Ser
        595                 600                 605             
Leu Ser Gln Thr Met Gly Phe Pro Gln Asp Gln Ile Arg Leu Trp Pro
    610                 615                 620                 
Met Gln Ala Arg Ser Asn Gly Thr Lys Arg Pro Ala Met Leu Asp Asn
625                 630                 635                 640 
Glu Ala Asp Gly Asn Lys Thr Met Ile Glu Leu Ser Asp Asn Glu Asn
                645                 650                 655     
Pro Trp Thr Ile Phe Leu Glu Thr Val Asp Pro Glu Leu Ala Ala Ser
            660                 665                 670         
Gly Ala Thr Leu Pro Lys Phe Asp Lys Asp His Asp Val Met Leu Phe
        675                 680                 685             
Leu Lys Met Tyr Asp Pro Lys Thr Arg Ser Leu Asn Tyr Cys Gly His
    690                 695                 700                 
Ile Tyr Thr Pro Ile Ser Cys Lys Ile Arg Asp Leu Leu Pro Val Met
705                 710                 715                 720 
Cys Asp Arg Ala Gly Phe Ile Gln Asp Thr Ser Leu Ile Leu Tyr Glu
                725                 730                 735     
Glu Val Lys Pro Asn Leu Thr Glu Arg Ile Gln Asp Tyr Asp Val Ser
            740                 745                 750         
Leu Asp Lys Ala Leu Asp Glu Leu Met Asp Gly Asp Ile Ile Val Phe
        755                 760                 765             
Gln Lys Asp Asp Pro Glu Asn Asp Asn Ser Glu Leu Pro Thr Ala Lys
    770                 775                 780                 
Glu Tyr Phe Arg Asp Leu Tyr His Arg Val Asp Val Ile Phe Cys Asp
785                 790                 795                 800 
Lys Thr Ile Pro Asn Asp Pro Gly Phe Val Val Thr Leu Ser Asn Arg
                805                 810                 815     
Met Asn Tyr Phe Gln Val Ala Lys Thr Val Ala Gln Arg Leu Asn Thr
            820                 825                 830         
Asp Pro Met Leu Leu Gln Phe Phe Lys Ser Gln Gly Tyr Arg Asp Gly
        835                 840                 845             
Pro Gly Asn Pro Leu Arg His Asn Tyr Glu Gly Thr Leu Arg Asp Leu
    850                 855                 860                 
Leu Gln Phe Phe Lys Pro Arg Gln Pro Lys Lys Leu Tyr Tyr Gln Gln
865                 870                 875                 880 
Leu Lys Met Lys Ile Thr Asp Phe Glu Asn Arg Arg Ser Phe Lys Cys
                885                 890                 895     
Ile Trp Leu Asn Ser Gln Phe Arg Glu Glu Glu Ile Thr Leu Tyr Pro
            900                 905                 910         
Asp Lys His Gly Cys Val Arg Asp Leu Leu Glu Glu Cys Lys Lys Ala
        915                 920                 925             
Val Glu Leu Gly Glu Lys Ala Ser Gly Lys Leu Arg Leu Leu Glu Ile
    930                 935                 940                 
Val Ser Tyr Lys Ile Ile Gly Val His Gln Glu Asp Glu Leu Leu Glu
945                 950                 955                 960 
Cys Leu Ser Pro Ala Thr Ser Arg Thr Phe Arg Ile Glu Glu Ile Pro
                965                 970                 975     
Leu Asp Gln Val Asp Ile Asp Lys Glu Asn Glu Met Leu Val Thr Val
            980                 985                 990         
Ala His Phe His Lys Glu Val Phe Gly Thr Phe Gly Ile Pro Phe Leu
        995                 1000                1005            
Leu Arg Ile His Gln Gly Glu His Phe Arg Glu Val Met Lys Arg Ile
    1010                1015                1020                
Gln Ser Leu Leu Asp Ile Gln Glu Lys Glu Phe Glu Lys Phe Lys Phe
1025                1030                1035                1040
Ala Ile Val Met Thr Gly Arg His Gln Tyr Ile Asn Glu Asp Glu Tyr
                1045                1050                1055    
Glu Val Asn Leu Lys Asp Phe Glu Pro Gln Pro Gly Asn Met Ser His
            1060                1065                1070        
Pro Arg Pro Trp Leu Gly Leu Asp His Phe Asn Lys Ala Pro Lys Arg
        1075                1080                1085            
Ser Arg Tyr Thr Tyr Leu Glu Lys Ala Ile Lys Ile His Asn
    1090                1095                1100        


<210> 524
<211> 283
<212> PRT
<213> Homo sapiens

<400> 524
Met Ala Val Pro Pro Thr Tyr Ala Asp Leu Gly Lys Ser Ala Arg Asp
 1               5                  10                  15      
Val Phe Thr Lys Gly Tyr Gly Phe Gly Leu Ile Lys Leu Asp Leu Lys
            20                  25                  30          
Thr Lys Ser Glu Asn Gly Leu Glu Phe Thr Ser Ser Gly Ser Ala Asn
        35                  40                  45              
Thr Glu Thr Thr Lys Val Thr Gly Ser Leu Glu Thr Lys Tyr Arg Trp
    50                  55                  60                  
Thr Glu Tyr Gly Leu Thr Phe Thr Glu Lys Trp Asn Thr Asp Asn Thr
65                  70                  75                  80  
Leu Gly Thr Glu Ile Thr Val Glu Asp Gln Leu Ala Arg Gly Leu Lys
                85                  90                  95      
Leu Thr Phe Asp Ser Ser Phe Ser Pro Asn Thr Gly Lys Lys Asn Ala
            100                 105                 110         
Lys Ile Lys Thr Gly Tyr Lys Arg Glu His Ile Asn Leu Gly Cys Asp
        115                 120                 125             
Met Asp Phe Asp Ile Ala Gly Pro Ser Ile Arg Gly Ala Leu Val Leu
    130                 135                 140                 
Gly Tyr Glu Gly Trp Leu Ala Gly Tyr Gln Met Asn Phe Glu Thr Ala
145                 150                 155                 160 
Lys Ser Arg Val Thr Gln Ser Asn Phe Ala Val Gly Tyr Lys Thr Asp
                165                 170                 175     
Glu Phe Gln Leu His Thr Asn Val Asn Asp Gly Thr Glu Phe Gly Gly
            180                 185                 190         
Ser Ile Tyr Gln Lys Val Asn Lys Lys Leu Glu Thr Ala Val Asn Leu
        195                 200                 205             
Ala Trp Thr Ala Gly Asn Ser Asn Thr Arg Phe Gly Ile Ala Ala Lys
    210                 215                 220                 
Tyr Gln Ile Asp Pro Asp Ala Cys Phe Ser Ala Lys Val Asn Asn Ser
225                 230                 235                 240 
Ser Leu Ile Gly Leu Gly Tyr Thr Gln Thr Leu Lys Pro Gly Ile Lys
                245                 250                 255     
Leu Thr Leu Ser Ala Leu Leu Asp Gly Lys Asn Val Asn Ala Gly Gly
            260                 265                 270         
His Lys Leu Gly Leu Gly Leu Glu Phe Gln Ala
        275                 280             


<210> 525
<211> 559
<212> PRT
<213> Homo sapiens

<400> 525
Met Pro Leu Val Lys Arg Asn Ile Asp Pro Arg His Leu Cys His Thr
 1               5                  10                  15      
Ala Leu Pro Arg Gly Ile Lys Asn Glu Leu Glu Cys Val Thr Asn Ile
            20                  25                  30          
Ser Leu Ala Asn Ile Ile Arg Gln Leu Ser Ser Leu Ser Lys Tyr Ala
        35                  40                  45              
Glu Asp Ile Phe Gly Glu Leu Phe Asn Glu Ala His Ser Phe Ser Phe
    50                  55                  60                  
Arg Val Asn Ser Leu Gln Glu Arg Val Asp Arg Leu Ser Val Ser Val
65                  70                  75                  80  
Thr Gln Leu Asp Pro Lys Glu Glu Glu Leu Ser Leu Gln Asp Ile Thr
                85                  90                  95      
Met Arg Lys Ala Phe Arg Ser Ser Thr Ile Gln Asp Gln Gln Leu Phe
            100                 105                 110         
Asp Arg Lys Thr Leu Pro Ile Pro Leu Gln Glu Thr Tyr Asp Val Cys
        115                 120                 125             
Glu Gln Pro Pro Pro Leu Asn Ile Leu Thr Pro Tyr Arg Asp Asp Gly
    130                 135                 140                 
Lys Glu Gly Leu Lys Phe Tyr Thr Asn Pro Ser Tyr Phe Phe Asp Leu
145                 150                 155                 160 
Trp Lys Glu Lys Met Leu Gln Asp Thr Glu Asp Lys Arg Lys Glu Lys
                165                 170                 175     
Arg Lys Gln Lys Gln Lys Asn Leu Asp Arg Pro His Glu Pro Glu Lys
            180                 185                 190         
Val Pro Arg Ala Pro His Asp Arg Arg Arg Glu Trp Gln Lys Leu Ala
        195                 200                 205             
Gln Gly Pro Glu Leu Ala Glu Asp Asp Ala Asn Leu Leu His Lys His
    210                 215                 220                 
Ile Glu Val Ala Asn Gly Pro Ala Ser His Phe Glu Thr Arg Pro Gln
225                 230                 235                 240 
Thr Tyr Val Asp His Met Asp Gly Ser Tyr Ser Leu Ser Ala Leu Pro
                245                 250                 255     
Phe Ser Gln Met Ser Glu Leu Leu Thr Arg Ala Glu Glu Arg Val Leu
            260                 265                 270         
Val Arg Pro His Glu Pro Pro Pro Pro Pro Pro Met His Gly Ala Gly
        275                 280                 285             
Asp Ala Lys Pro Ile Pro Thr Cys Ile Ser Ser Ala Thr Gly Leu Ile
    290                 295                 300                 
Glu Asn Arg Pro Gln Ser Pro Ala Thr Gly Arg Thr Pro Val Phe Val
305                 310                 315                 320 
Ser Pro Thr Pro Pro Pro Pro Pro Pro Pro Leu Pro Ser Ala Leu Ser
                325                 330                 335     
Thr Ser Ser Leu Arg Ala Ser Met Thr Ser Thr Pro Pro Pro Pro Val
            340                 345                 350         
Pro Pro Pro Pro Pro Pro Pro Ala Thr Ala Leu Gln Ala Pro Ala Val
        355                 360                 365             
Pro Pro Pro Pro Ala Pro Leu Gln Ile Ala Pro Gly Val Leu His Pro
    370                 375                 380                 
Ala Pro Pro Pro Ile Ala Pro Pro Leu Val Gln Pro Ser Pro Pro Val
385                 390                 395                 400 
Ala Arg Ala Ala Pro Val Cys Glu Thr Val Pro Val His Pro Leu Pro
                405                 410                 415     
Gln Gly Glu Val Gln Gly Leu Pro Pro Pro Pro Pro Pro Pro Pro Leu
            420                 425                 430         
Pro Pro Pro Gly Ile Arg Pro Ser Ser Pro Val Thr Val Thr Ala Leu
        435                 440                 445             
Ala His Pro Pro Ser Gly Leu His Pro Thr Pro Ser Thr Ala Pro Gly
    450                 455                 460                 
Pro His Val Pro Leu Met Pro Pro Ser Pro Pro Ser Gln Val Ile Pro
465                 470                 475                 480 
Ala Ser Glu Pro Lys Arg His Pro Ser Thr Leu Pro Val Ile Ser Asp
                485                 490                 495     
Ala Arg Ser Val Leu Leu Glu Ala Ile Arg Lys Gly Ile Gln Leu Arg
            500                 505                 510         
Lys Val Glu Glu Gln Arg Glu Gln Glu Ala Lys His Glu Arg Ile Glu
        515                 520                 525             
Asn Asp Val Ala Thr Ile Leu Ser Arg Arg Ile Ala Val Glu Tyr Ser
    530                 535                 540                 
Asp Ser Glu Asp Asp Ser Glu Phe Asp Glu Val Asp Trp Leu Glu
545                 550                 555                 


<210> 526
<211> 245
<212> PRT
<213> Homo sapiens

<400> 526
Met Asp Lys Asn Glu Leu Val Gln Lys Ala Lys Leu Ala Glu Gln Ala
 1               5                  10                  15      
Glu Arg Tyr Asp Asp Met Ala Ala Cys Met Lys Ser Val Thr Glu Gln
            20                  25                  30          
Gly Ala Glu Leu Ser Asn Glu Glu Arg Asn Leu Leu Ser Val Ala Tyr
        35                  40                  45              
Lys Asn Val Val Gly Ala Arg Arg Ser Ser Trp Arg Val Val Ser Ser
    50                  55                  60                  
Ile Glu Gln Lys Thr Glu Gly Ala Glu Lys Lys Gln Gln Met Ala Arg
65                  70                  75                  80  
Glu Tyr Arg Glu Lys Ile Glu Thr Glu Leu Arg Asp Ile Cys Asn Asp
                85                  90                  95      
Val Leu Ser Leu Leu Glu Lys Phe Leu Ile Pro Asn Ala Ser Gln Ala
            100                 105                 110         
Glu Ser Lys Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Tyr Arg Tyr
        115                 120                 125             
Leu Ala Glu Val Ala Ala Gly Asp Asp Lys Lys Gly Ile Val Asp Gln
    130                 135                 140                 
Ser Gln Gln Ala Tyr Gln Glu Ala Phe Glu Ile Ser Lys Lys Glu Met
145                 150                 155                 160 
Gln Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn Phe Ser Val
                165                 170                 175     
Phe Tyr Tyr Glu Ile Leu Asn Ser Pro Glu Lys Ala Cys Ser Leu Ala
            180                 185                 190         
Lys Thr Ala Phe Asp Glu Ala Ile Ala Glu Leu Asp Thr Leu Ser Glu
        195                 200                 205             
Glu Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu Arg Asp Asn
    210                 215                 220                 
Leu Thr Leu Trp Thr Ser Asp Thr Gln Gly Asp Glu Ala Glu Ala Gly
225                 230                 235                 240 
Glu Gly Gly Glu Asn
                245 


<210> 527
<211> 630
<212> PRT
<213> Homo sapiens

<400> 527
Met Ser Val Ser Ser Gly Val Gln Ile Leu Thr Lys Pro Glu Thr Val
 1               5                  10                  15      
Asp Arg Arg Arg Ser Ala Glu Thr Thr Lys Glu Ala Gly Arg Pro Leu
            20                  25                  30          
Glu Met Ala Val Ser Glu Pro Glu Ala Ser Ala Ala Glu Trp Lys Gln
        35                  40                  45              
Leu Asp Pro Ala Gln Ser Asn Leu Tyr Asn Asp Val Met Leu Glu Asn
    50                  55                  60                  
Tyr Cys Asn Gln Ala Ser Met Gly Cys Gln Ala Pro Lys Pro Asp Met
65                  70                  75                  80  
Ile Ser Lys Leu Glu Lys Gly Glu Ala Pro Trp Leu Gly Lys Gly Lys
                85                  90                  95      
Arg Pro Ser Gln Gly Cys Pro Ser Lys Ile Ala Arg Pro Lys Gln Lys
            100                 105                 110         
Glu Thr Asp Gly Lys Val Gln Lys Asp Asp Asp Gln Leu Glu Asn Ile
        115                 120                 125             
Gln Lys Ser Gln Asn Lys Leu Leu Arg Glu Val Ala Val Lys Lys Lys
    130                 135                 140                 
Thr Gln Ala Lys Lys Asn Gly Ser Asp Cys Gly Ser Leu Gly Lys Lys
145                 150                 155                 160 
Asn Asn Leu His Lys Lys His Val Pro Ser Lys Lys Arg Leu Leu Lys
                165                 170                 175     
Phe Glu Ser Cys Gly Lys Ile Leu Lys Gln Asn Leu Asp Leu Pro Asp
            180                 185                 190         
His Ser Arg Asn Cys Val Lys Arg Lys Ser Asp Ala Ala Lys Glu His
        195                 200                 205             
Lys Lys Ser Phe Asn His Ser Leu Ser Asp Thr Arg Lys Gly Lys Lys
    210                 215                 220                 
Gln Thr Gly Lys Lys His Glu Lys Leu Ser Ser His Ser Ser Ser Asp
225                 230                 235                 240 
Lys Cys Asn Lys Thr Gly Lys Lys His Asp Lys Leu Cys Cys His Ser
                245                 250                 255     
Ser Ser His Ile Lys Gln Asp Lys Ile Gln Thr Gly Glu Lys His Glu
            260                 265                 270         
Lys Ser Pro Ser Leu Ser Ser Ser Thr Lys His Glu Lys Pro Gln Ala
        275                 280                 285             
Cys Val Lys Pro Tyr Glu Cys Asn Gln Cys Gly Lys Val Leu Ser His
    290                 295                 300                 
Lys Gln Gly Leu Ile Asp His Gln Arg Val His Thr Gly Glu Lys Pro
305                 310                 315                 320 
Tyr Glu Cys Asn Glu Cys Gly Ile Ala Phe Ser Gln Lys Ser His Leu
                325                 330                 335     
Val Val His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Ile
            340                 345                 350         
Gln Cys Gly Lys Ala His Gly His Lys His Ala Leu Thr Asp His Leu
        355                 360                 365             
Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Ala Glu Cys Gly Lys
    370                 375                 380                 
Thr Phe Arg His Ser Ser Asn Leu Ile Gln His Val Arg Ser His Thr
385                 390                 395                 400 
Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ser Phe Arg Tyr
                405                 410                 415     
Asn Ser Ser Leu Thr Glu His Val Arg Thr His Thr Gly Glu Ile Pro
            420                 425                 430         
Tyr Glu Cys Asn Glu Cys Gly Lys Ala Phe Lys Tyr Ser Ser Ser Leu
        435                 440                 445             
Thr Lys His Met Arg Ile His Thr Gly Glu Lys Pro Phe Glu Cys Asn
    450                 455                 460                 
Glu Cys Gly Lys Ala Phe Ser Lys Lys Ser His Leu Ile Ile His Gln
465                 470                 475                 480 
Arg Thr His Thr Lys Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys
                485                 490                 495     
Ala Phe Gly His Ser Ser Ser Leu Thr Tyr His Met Arg Thr His Thr
            500                 505                 510         
Gly Glu Ser Pro Phe Glu Cys Asn Gln Cys Gly Lys Gly Phe Lys Gln
        515                 520                 525             
Ile Glu Gly Leu Thr Gln His Gln Arg Val His Thr Gly Glu Lys Pro
    530                 535                 540                 
Tyr Glu Cys Asn Glu Cys Gly Lys Ala Phe Ser Gln Lys Ser His Leu
545                 550                 555                 560 
Ile Val His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Asn
                565                 570                 575     
Glu Cys Glu Lys Ala Phe Asn Ala Lys Ser Gln Leu Val Ile His Gln
            580                 585                 590         
Arg Ser His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys
        595                 600                 605             
Thr Phe Lys Gln Asn Ala Ser Leu Thr Lys His Val Lys Thr His Ser
    610                 615                 620                 
Glu Asp Lys Ser His Glu
625                 630 


<210> 528
<211> 589
<212> PRT
<213> Homo sapiens

<400> 528
Met Cys Gly Pro Phe Leu Lys Asp Ile Leu His Leu Ala Glu His Gln
 1               5                  10                  15      
Gly Thr Gln Ser Glu Glu Lys Pro Tyr Thr Cys Gly Ala Cys Gly Arg
            20                  25                  30          
Asp Phe Trp Leu Asn Ala Asn Leu His Gln His Gln Lys Glu His Ser
        35                  40                  45              
Gly Gly Lys Pro Phe Arg Trp Tyr Lys Asp Arg Asp Ala Leu Met Lys
    50                  55                  60                  
Ser Ser Lys Val His Leu Ser Glu Asn Pro Phe Thr Cys Arg Glu Gly
65                  70                  75                  80  
Gly Lys Val Ile Leu Gly Ser Cys Asp Leu Leu Gln Leu Gln Ala Val
                85                  90                  95      
Asp Ser Gly Gln Lys Pro Tyr Ser Asn Leu Gly Gln Leu Pro Glu Val
            100                 105                 110         
Cys Thr Thr Gln Lys Leu Phe Glu Cys Ser Asn Cys Gly Lys Ala Phe
        115                 120                 125             
Leu Lys Ser Ser Thr Leu Pro Asn His Leu Arg Thr His Ser Glu Glu
    130                 135                 140                 
Ile Pro Phe Thr Cys Pro Thr Gly Gly Asn Phe Leu Glu Glu Lys Ser
145                 150                 155                 160 
Ile Leu Gly Asn Lys Lys Phe His Thr Gly Glu Ile Pro His Val Cys
                165                 170                 175     
Lys Glu Cys Gly Lys Ala Phe Ser His Ser Ser Lys Leu Arg Lys His
            180                 185                 190         
Gln Lys Phe His Thr Glu Val Lys Tyr Tyr Glu Cys Ile Ala Cys Gly
        195                 200                 205             
Lys Thr Phe Asn His Lys Leu Thr Phe Val His His Gln Arg Ile His
    210                 215                 220                 
Ser Gly Glu Arg Pro Tyr Glu Cys Asp Glu Cys Gly Lys Ala Phe Ser
225                 230                 235                 240 
Asn Arg Ser His Leu Ile Arg His Glu Lys Val His Thr Gly Glu Arg
                245                 250                 255     
Pro Phe Glu Cys Leu Lys Cys Gly Arg Ala Phe Ser Gln Ser Ser Asn
            260                 265                 270         
Phe Leu Arg His Gln Lys Val His Thr Gln Val Arg Pro Tyr Glu Cys
        275                 280                 285             
Ser Gln Cys Gly Lys Ser Phe Ser Arg Ser Ser Ala Leu Ile Gln His
    290                 295                 300                 
Trp Arg Val His Thr Gly Glu Arg Pro Tyr Glu Cys Ser Glu Cys Gly
305                 310                 315                 320 
Arg Ala Phe Asn Asn Asn Ser Asn Leu Ala Gln His Gln Lys Val His
                325                 330                 335     
Thr Gly Glu Arg Pro Phe Glu Cys Ser Glu Cys Gly Arg Asp Phe Ser
            340                 345                 350         
Gln Ser Ser His Leu Leu Arg His Gln Lys Val His Thr Gly Glu Arg
        355                 360                 365             
Pro Phe Glu Cys Cys Asp Cys Gly Lys Ala Phe Ser Asn Ser Ser Thr
    370                 375                 380                 
Leu Ile Gln His Gln Lys Val His Thr Gly Gln Arg Pro Tyr Glu Cys
385                 390                 395                 400 
Ser Glu Cys Arg Lys Ser Phe Ser Arg Ser Ser Ser Leu Ile Gln His
                405                 410                 415     
Trp Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Ser Glu Cys Gly
            420                 425                 430         
Lys Ala Phe Ala His Ser Ser Thr Leu Ile Glu His Trp Arg Val His
        435                 440                 445             
Thr Lys Glu Arg Pro Tyr Glu Cys Asn Glu Cys Gly Lys Phe Phe Ser
    450                 455                 460                 
Gln Asn Ser Ile Leu Ile Lys His Gln Lys Val His Thr Gly Glu Lys
465                 470                 475                 480 
Pro Tyr Lys Cys Ser Glu Cys Gly Lys Phe Phe Ser Arg Lys Ser Ser
                485                 490                 495     
Leu Ile Cys His Trp Arg Val His Thr Gly Glu Arg Pro Tyr Glu Cys
            500                 505                 510         
Ser Glu Cys Gly Arg Ala Phe Ser Ser Asn Ser His Leu Val Arg His
        515                 520                 525             
Gln Arg Val His Thr Gln Glu Arg Pro Tyr Glu Cys Ile Gln Cys Gly
    530                 535                 540                 
Lys Ala Phe Ser Glu Arg Ser Thr Leu Val Arg His Gln Lys Val His
545                 550                 555                 560 
Thr Arg Glu Arg Thr Tyr Glu Cys Ser Gln Cys Gly Lys Leu Phe Ser
                565                 570                 575     
His Leu Cys Asn Leu Ala Gln His Lys Lys Ile His Thr
            580                 585                 


<210> 529
<211> 3394
<212> PRT
<213> Homo sapiens

<400> 529
Asn Cys Gln Thr Gln Arg Ala Ile Ser Gly Gln Leu Gly Asp Ile Arg
 1               5                  10                  15      
Lys Met Pro Pro Ala Pro Ser Gly Pro Lys Ala Ser Pro Met Pro Val
            20                  25                  30          
Pro Thr Glu Ser Ser Ser Gln Lys Thr Ala Val Pro Pro Gln Val Lys
        35                  40                  45              
Leu Val Lys Lys Gln Glu Gln Glu Val Lys Thr Glu Ala Glu Lys Val
    50                  55                  60                  
Ile Leu Glu Lys Val Lys Glu Thr Leu Ser Met Glu Lys Ile Pro Pro
65                  70                  75                  80  
Met Val Thr Thr Asp Gln Lys Gln Glu Glu Ser Lys Leu Glu Lys Asp
                85                  90                  95      
Lys Ala Ser Ala Leu Gln Glu Lys Lys Pro Leu Pro Glu Glu Lys Lys
            100                 105                 110         
Leu Ile Pro Glu Glu Glu Lys Ile Arg Ser Glu Glu Lys Lys Pro Leu
        115                 120                 125             
Leu Glu Glu Lys Lys Pro Thr Pro Glu Asp Lys Lys Leu Leu Pro Glu
    130                 135                 140                 
Ala Lys Thr Ser Ala Pro Glu Glu Gln Lys His Asp Leu Leu Lys Ser
145                 150                 155                 160 
Gln Val Gln Ile Ala Glu Glu Lys Leu Glu Gly Arg Val Ala Pro Lys
                165                 170                 175     
Thr Val Gln Glu Gly Lys Gln Pro Gln Thr Lys Met Glu Gly Leu Pro
            180                 185                 190         
Ser Gly Thr Pro Gln Ser Leu Pro Lys Glu Asp Asp Lys Thr Thr Lys
        195                 200                 205             
Thr Ile Lys Glu Gln Pro Gln Pro Pro Cys Thr Ala Lys Pro Asp Gln
    210                 215                 220                 
Glu Lys Glu Asp Asp Lys Ser Asp Thr Ser Ser Ser Gln Gln Pro Lys
225                 230                 235                 240 
Ser Pro Gln Gly Leu Ser Asp Thr Gly Tyr Ser Ser Asp Gly Ile Ser
                245                 250                 255     
Ser Ser Leu Gly Glu Ile Pro Ser Leu Ile Pro Thr Asp Glu Lys Asp
            260                 265                 270         
Ile Leu Lys Gly Leu Lys Lys Asp Ser Phe Ser Gln Glu Ser Ser Pro
        275                 280                 285             
Ser Ser Pro Ser Asp Leu Ala Lys Leu Glu Ser Thr Val Leu Ser Ile
    290                 295                 300                 
Leu Glu Ala Gln Ala Ser Thr Leu Ala Asp Glu Lys Ser Glu Lys Lys
305                 310                 315                 320 
Thr Gln Pro His Glu Val Ser Pro Glu Gln Pro Lys Asp Gln Glu Lys
                325                 330                 335     
Thr Gln Ser Leu Ser Glu Thr Leu Glu Ile Thr Ile Ser Glu Glu Glu
            340                 345                 350         
Ile Lys Glu Ser Gln Glu Glu Arg Lys Asp Thr Phe Lys Lys Asp Ser
        355                 360                 365             
Gln Gln Asp Ile Pro Ser Ser Lys Asp His Lys Glu Lys Ser Glu Phe
    370                 375                 380                 
Val Asp Asp Ile Thr Thr Arg Arg Glu Pro Tyr Asp Ser Val Glu Glu
385                 390                 395                 400 
Ser Ser Glu Ser Glu Asn Ser Pro Val Pro Gln Arg Lys Arg Arg Thr
                405                 410                 415     
Ser Val Gly Ser Ser Ser Ser Asp Glu Tyr Lys Gln Glu Asp Ser Gln
            420                 425                 430         
Gly Ser Gly Glu Glu Glu Asp Phe Ile Arg Lys Gln Ile Ile Glu Met
        435                 440                 445             
Ser Ala Asp Glu Asp Ala Ser Gly Ser Glu Asp Asp Glu Phe Ile Arg
    450                 455                 460                 
Asn Gln Leu Lys Glu Ile Ser Ser Ser Thr Glu Ser Gln Lys Lys Glu
465                 470                 475                 480 
Glu Thr Lys Gly Lys Gly Lys Ile Thr Ala Gly Lys His Arg Arg Leu
                485                 490                 495     
Thr Arg Lys Ser Ser Thr Ser Ile Asp Glu Asp Ala Gly Arg Arg His
            500                 505                 510         
Ser Trp His Asp Glu Asp Asp Glu Ala Phe Asp Glu Ser Pro Glu Leu
        515                 520                 525             
Lys Tyr Arg Glu Thr Lys Ser Gln Glu Ser Glu Glu Leu Val Val Thr
    530                 535                 540                 
Gly Gly Gly Gly Leu Arg Arg Phe Lys Thr Ile Glu Leu Asn Ser Thr
545                 550                 555                 560 
Ile Ala Asp Lys Tyr Ser Ala Glu Ser Ser Gln Lys Lys Thr Ser Leu
                565                 570                 575     
Tyr Phe Asp Glu Glu Pro Glu Leu Glu Met Glu Ser Leu Thr Asp Ser
            580                 585                 590         
Pro Glu Asp Arg Ser Arg Gly Glu Gly Ser Ser Ser Leu His Ala Ser
        595                 600                 605             
Ser Phe Thr Pro Gly Thr Ser Pro Thr Ser Val Ser Ser Leu Asp Glu
    610                 615                 620                 
Asp Ser Asp Ser Ser Pro Ser His Lys Lys Gly Glu Ser Lys Gln Gln
625                 630                 635                 640 
Arg Lys Ala Arg His Arg Pro His Gly Pro Leu Leu Pro Thr Ile Glu
                645                 650                 655     
Asp Ser Ser Glu Glu Glu Glu Leu Arg Glu Glu Glu Glu Leu Leu Lys
            660                 665                 670         
Glu Gln Glu Lys Gln Arg Glu Ile Glu Gln Gln Gln Arg Lys Ser Ser
        675                 680                 685             
Ser Lys Lys Ser Lys Lys Asp Lys Asp Glu Leu Arg Ala Gln Arg Arg
    690                 695                 700                 
Arg Glu Arg Pro Lys Thr Pro Pro Ser Asn Leu Ser Pro Ile Glu Asp
705                 710                 715                 720 
Ala Ser Pro Thr Glu Glu Leu Arg Gln Ala Ala Glu Met Glu Glu Leu
                725                 730                 735     
His Arg Ser Ser Cys Ser Glu Tyr Ser Pro Ser Ile Glu Ser Asp Pro
            740                 745                 750         
Glu Gly Phe Glu Ile Ser Pro Glu Lys Ile Ile Glu Val Gln Lys Val
        755                 760                 765             
Tyr Lys Leu Pro Thr Ala Val Ser Leu Tyr Ser Pro Thr Asp Glu Gln
    770                 775                 780                 
Ser Ile Met Gln Lys Glu Gly Ser Gln Lys Ala Leu Lys Ser Ala Glu
785                 790                 795                 800 
Glu Met Tyr Glu Glu Met Met His Lys Thr His Lys Tyr Lys Ala Phe
                805                 810                 815     
Pro Ala Ala Asn Glu Arg Asp Glu Val Phe Glu Lys Glu Pro Leu Tyr
            820                 825                 830         
Gly Gly Met Leu Ile Glu Asp Tyr Ile Tyr Glu Ser Leu Val Glu Asp
        835                 840                 845             
Thr Tyr Asn Gly Ser Val Asp Gly Ser Leu Leu Thr Arg Gln Glu Glu
    850                 855                 860                 
Glu Asn Gly Phe Met Gln Gln Lys Gly Arg Glu Gln Lys Ile Arg Leu
865                 870                 875                 880 
Ser Glu Gln Ile Tyr Glu Asp Pro Met Gln Lys Ile Thr Asp Leu Gln
                885                 890                 895     
Lys Glu Phe Tyr Glu Leu Glu Ser Leu His Ser Val Val Pro Gln Glu
            900                 905                 910         
Asp Ile Val Ser Ser Ser Phe Ile Ile Pro Glu Ser His Glu Ile Val
        915                 920                 925             
Asp Leu Gly Thr Met Val Thr Ser Thr Glu Glu Glu Arg Lys Leu Leu
    930                 935                 940                 
Asp Ala Asp Ala Ala Tyr Glu Glu Leu Met Lys Arg Gln Gln Met Gln
945                 950                 955                 960 
Leu Thr Pro Gly Ser Ser Pro Thr Gln Ala Pro Ile Gly Glu Asp Met
                965                 970                 975     
Thr Glu Ser Thr Met Asp Phe Asp Arg Met Pro Asp Ala Ser Leu Thr
            980                 985                 990         
Ser Ser Val Leu Ser Gly Ala Ser Leu Thr Asp Ser Thr Ser Ser Ala
        995                 1000                1005            
Thr Leu Ser Ile Pro Asp Val Lys Ile Thr Gln His Phe Ser Thr Glu
    1010                1015                1020                
Glu Ile Glu Asp Glu Tyr Val Thr Asp Tyr Thr Arg Glu Ile Gln Glu
1025                1030                1035                1040
Ile Ile Ala His Glu Ser Leu Ile Leu Thr Tyr Ser Glu Pro Ser Glu
                1045                1050                1055    
Ser Ala Thr Ser Val Pro Pro Ser Asp Thr Pro Ser Leu Thr Ser Ser
            1060                1065                1070        
Val Ser Ser Val Cys Thr Thr Asp Ser Ser Ser Pro Ile Thr Thr Leu
        1075                1080                1085            
Asp Ser Ile Thr Thr Val Tyr Thr Glu Pro Val Asp Met Ile Thr Lys
    1090                1095                1100                
Phe Glu Asp Ser Glu Glu Ile Ser Ser Ser Thr Tyr Phe Pro Gly Ser
1105                1110                1115                1120
Ile Ile Asp Tyr Pro Glu Glu Ile Ser Val Ser Leu Asp Arg Thr Ala
                1125                1130                1135    
Pro Pro Asp Gly Arg Ala Ser Ala Asp His Ile Val Ile Ser Leu Ser
            1140                1145                1150        
Asp Met Ala Ser Ser Ile Ile Glu Ser Val Val Pro Lys Pro Glu Gly
        1155                1160                1165            
Pro Val Ala Asp Thr Val Ser Thr Asp Leu Leu Ile Ser Glu Lys Asp
    1170                1175                1180                
Pro Val Lys Lys Ala Lys Lys Glu Thr Gly Asn Gly Ile Ile Leu Glu
1185                1190                1195                1200
Val Leu Glu Ala Tyr Arg Asp Lys Lys Glu Leu Glu Ala Glu Arg Thr
                1205                1210                1215    
Lys Ser Ser Leu Ser Glu Thr Val Phe Asp His Pro Pro Ser Ser Val
            1220                1225                1230        
Ile Ala Leu Pro Met Lys Glu Gln Leu Ser Thr Thr Tyr Phe Thr Ser
        1235                1240                1245            
Gly Glu Thr Phe Gly Gln Glu Lys Pro Ala Ser Gln Leu Pro Ser Gly
    1250                1255                1260                
Ser Pro Ser Val Ser Ser Leu Pro Ala Lys Pro Arg Pro Phe Phe Arg
1265                1270                1275                1280
Ser Ser Ser Leu Asp Ile Ser Ala Gln Pro Pro Pro Pro Pro Pro Pro
                1285                1290                1295    
Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Leu
            1300                1305                1310        
Pro Pro Pro Thr Ser Pro Lys Pro Thr Ile Leu Pro Lys Lys Lys Leu
        1315                1320                1325            
Thr Val Ala Ser Pro Val Thr Thr Ala Thr Pro Leu Phe Asp Ala Val
    1330                1335                1340                
Thr Thr Leu Glu Thr Thr Ala Val Leu Arg Ser Asn Gly Leu Pro Val
1345                1350                1355                1360
Thr Arg Ile Cys Thr Thr Ala Pro Pro Pro Val Pro Pro Lys Pro Ser
                1365                1370                1375    
Ser Ile Pro Ser Gly Leu Val Phe Thr His Arg Pro Glu Pro Ser Lys
            1380                1385                1390        
Pro Pro Ile Ala Pro Lys Pro Val Ile Pro Gln Leu Pro Thr Thr Thr
        1395                1400                1405            
Gln Lys Pro Thr Asp Ile His Pro Lys Pro Thr Gly Leu Ser Leu Thr
    1410                1415                1420                
Ser Ser Met Thr Leu Asn Leu Val Thr Ser Ala Asp Tyr Lys Leu Pro
1425                1430                1435                1440
Ser Pro Thr Ser Pro Leu Ser Pro His Ser Asn Lys Ser Ser Pro Arg
                1445                1450                1455    
Phe Ser Lys Ser Leu Thr Glu Thr Tyr Val Val Ile Thr Leu Pro Ser
            1460                1465                1470        
Glu Pro Gly Thr Pro Thr Asp Ser Ser Ala Ser Gln Ala Ile Thr Ser
        1475                1480                1485            
Trp Pro Leu Gly Ser Pro Ser Lys Asp Leu Val Ser Val Glu Pro Val
    1490                1495                1500                
Phe Ser Val Val Pro Pro Val Thr Ala Val Glu Ile Pro Ile Ser Ser
1505                1510                1515                1520
Glu Gln Thr Phe Tyr Ile Ser Gly Ala Leu Gln Thr Phe Ser Ala Thr
                1525                1530                1535    
Pro Val Thr Ala Pro Ser Ser Phe Gln Ala Ala Pro Thr Ser Val Thr
            1540                1545                1550        
Gln Phe Leu Thr Thr Glu Val Ser Lys Thr Glu Val Ser Ala Thr Arg
        1555                1560                1565            
Ser Thr Ala Pro Ser Val Gly Leu Ser Ser Ile Ser Ile Thr Ile Pro
    1570                1575                1580                
Pro Glu Pro Leu Ala Leu Asp Asn Ile His Leu Glu Lys Pro Gln Tyr
1585                1590                1595                1600
Lys Glu Asp Gly Lys Leu Gln Leu Val Gly Asp Val Ile Asp Leu Arg
                1605                1610                1615    
Thr Val Pro Lys Val Glu Val Lys Thr Thr Asp Lys Cys Ile Asp Leu
            1620                1625                1630        
Ser Ala Ser Thr Met Asp Val Lys Arg Gln Ile Thr Ala Asn Glu Val
        1635                1640                1645            
Tyr Gly Lys Gln Ile Ser Ala Val Gln Pro Ser Ile Ile Asn Leu Ser
    1650                1655                1660                
Val Thr Ser Ser Ile Val Thr Pro Val Ser Leu Ala Thr Glu Thr Val
1665                1670                1675                1680
Thr Phe Val Thr Cys Thr Ala Ser Ala Ser Tyr Thr Thr Gly Thr Glu
                1685                1690                1695    
Ser Leu Val Gly Ala Glu His Ala Met Thr Thr Pro Leu Gln Leu Thr
            1700                1705                1710        
Thr Ser Lys His Ala Glu Pro Pro Tyr Arg Ile Pro Ser Asp Gln Val
        1715                1720                1725            
Phe Pro Ile Ala Arg Glu Glu Ala Pro Ile Asn Leu Ser Leu Gly Thr
    1730                1735                1740                
Pro Ala His Ala Val Thr Leu Ala Ile Thr Lys Pro Val Thr Val Pro
1745                1750                1755                1760
Pro Val Gly Val Thr Asn Gly Trp Thr Asp Ser Thr Val Ser Gln Gly
                1765                1770                1775    
Ile Thr Asp Gly Glu Val Val Asp Leu Ser Thr Thr Lys Ser His Arg
            1780                1785                1790        
Thr Val Val Thr Met Asp Glu Ser Thr Ser Ser Val Met Thr Lys Ile
        1795                1800                1805            
Ile Glu Asp Glu Lys Pro Val Asp Leu Thr Ala Gly Arg Arg Ala Val
    1810                1815                1820                
Cys Cys Asp Val Val Tyr Lys Leu Pro Phe Gly Arg Ser Cys Thr Ala
1825                1830                1835                1840
Gln Gln Pro Ala Thr Thr Leu Pro Glu Asp Arg Phe Gly Tyr Arg Asp
                1845                1850                1855    
Asp His Tyr Gln Tyr Asp Arg Ser Gly Pro Tyr Gly Tyr Arg Gly Ile
            1860                1865                1870        
Gly Gly Met Lys Pro Ser Met Ser Asp Thr Asn Leu Ala Glu Ala Gly
        1875                1880                1885            
His Phe Phe Tyr Lys Ser Lys Asn Ala Phe Asp Tyr Ser Glu Gly Thr
    1890                1895                1900                
Asp Thr Ala Val Asp Leu Thr Ser Gly Arg Val Thr Thr Gly Glu Val
1905                1910                1915                1920
Met Asp Tyr Ser Ser Lys Thr Thr Gly Pro Tyr Pro Glu Thr Arg Gln
                1925                1930                1935    
Val Ile Ser Gly Ala Gly Ile Ser Thr Pro Gln Tyr Ser Thr Ala Arg
            1940                1945                1950        
Met Thr Pro Pro Pro Gly Pro Gln Tyr Cys Val Gly Ser Val Leu Arg
        1955                1960                1965            
Ser Ser Asn Gly Val Val Tyr Ser Ser Val Ala Thr Pro Thr Pro Ser
    1970                1975                1980                
Thr Phe Ala Ile Thr Thr Gln Pro Gly Ser Ile Phe Ser Thr Thr Val
1985                1990                1995                2000
Arg Asp Leu Ser Gly Ile His Thr Ala Asp Ala Val Thr Ser Leu Pro
                2005                2010                2015    
Ala Met His His Ser Gln Pro Met Pro Arg Ser Tyr Phe Ile Thr Thr
            2020                2025                2030        
Gly Ala Ser Glu Thr Asp Ile Ala Val Thr Gly Ile Asp Ile Ser Ala
        2035                2040                2045            
Ser Leu Gln Thr Ile Thr Met Glu Ser Leu Thr Ala Glu Thr Ile Asp
    2050                2055                2060                
Ser Val Pro Thr Leu Thr Thr Ala Ser Glu Val Phe Pro Glu Val Val
2065                2070                2075                2080
Gly Asp Glu Ser Ala Leu Leu Ile Val Pro Glu Glu Asp Lys Gln Gln
                2085                2090                2095    
Gln Gln Leu Asp Leu Glu Arg Glu Leu Leu Glu Leu Glu Lys Ile Lys
            2100                2105                2110        
Gln Gln Arg Phe Ala Glu Glu Leu Glu Trp Glu Arg Gln Glu Ile Gln
        2115                2120                2125            
Arg Phe Arg Glu Gln Glu Lys Ile Met Val Gln Lys Lys Leu Glu Glu
    2130                2135                2140                
Leu Gln Ser Met Lys Gln His Leu Leu Phe Gln Gln Glu Glu Glu Arg
2145                2150                2155                2160
Gln Ala Gln Phe Met Met Arg Gln Glu Thr Leu Ala Gln Gln Gln Leu
                2165                2170                2175    
Gln Leu Glu Gln Ile Gln Gln Leu Gln Gln Gln Leu His Gln Gln Leu
            2180                2185                2190        
Glu Glu Gln Lys Ile Arg Gln Ile Tyr Gln Tyr Asn Tyr Asp Pro Ser
        2195                2200                2205            
Gly Thr Ala Ser Pro Gln Thr Thr Thr Glu Gln Ala Ile Leu Glu Gly
    2210                2215                2220                
Gln Tyr Ala Ala Leu Glu Gly Ser Gln Phe Trp Ala Thr Glu Asp Ala
2225                2230                2235                2240
Thr Thr Thr Ala Ser Ala Val Val Ala Ile Glu Ile Pro Gln Ser Gln
                2245                2250                2255    
Gly Trp Tyr Thr Val Gln Ser Asp Gly Val Thr Gln Tyr Ile Ala Pro
            2260                2265                2270        
Pro Gly Ile Leu Ser Thr Val Ser Glu Ile Pro Leu Thr Asp Val Val
        2275                2280                2285            
Val Lys Glu Glu Lys Gln Pro Lys Lys Arg Ser Ser Gly Ala Lys Val
    2290                2295                2300                
Arg Gly Gln Tyr Asp Asp Met Gly Glu Asn Met Thr Asp Asp Pro Arg
2305                2310                2315                2320
Ser Phe Lys Lys Ile Val Asp Ser Gly Val Gln Thr Asp Asp Glu Asp
                2325                2330                2335    
Ala Thr Asp Arg Ser Tyr Val Ser Arg Arg Arg Arg Thr Lys Lys Ser
            2340                2345                2350        
Val Asp Thr Ser Val Gln Thr Asp Asp Glu Asp Gln Asp Glu Trp Asp
        2355                2360                2365            
Met Pro Thr Arg Ser Arg Arg Lys Ala Arg Val Gly Lys Tyr Gly Asp
    2370                2375                2380                
Ser Met Thr Glu Ala Asp Lys Thr Lys Pro Leu Ser Lys Val Ser Ser
2385                2390                2395                2400
Ile Ala Val Gln Thr Val Ala Glu Ile Ser Val Gln Thr Glu Pro Val
                2405                2410                2415    
Gly Thr Ile Arg Thr Pro Ser Ile Arg Ala Arg Val Asp Ala Lys Val
            2420                2425                2430        
Glu Ile Ile Lys His Ile Ser Ala Pro Glu Lys Thr Tyr Lys Gly Gly
        2435                2440                2445            
Ser Leu Gly Cys Gln Thr Glu Ala Asp Ser Asp Thr Gln Ser Pro Gln
    2450                2455                2460                
Tyr Leu Ser Ala Thr Ser Pro Pro Lys Asp Lys Lys Arg Pro Thr Pro
2465                2470                2475                2480
Leu Glu Ile Gly Tyr Ser Ser His Leu Arg Ala Asp Ser Thr Val Gln
                2485                2490                2495    
Leu Ala Pro Ser Pro Pro Lys Ser Pro Lys Val Leu Tyr Ser Pro Ile
            2500                2505                2510        
Ser Pro Leu Ser Pro Gly Lys Ala Leu Glu Ser Ala Phe Val Pro Tyr
        2515                2520                2525            
Glu Lys Pro Leu Pro Asp Asp Ile Ser Pro Gln Lys Val Leu His Pro
    2530                2535                2540                
Asp Met Ala Lys Val Pro Pro Ala Ser Pro Lys Thr Ala Lys Met Met
2545                2550                2555                2560
Gln Arg Ser Met Ser Asp Pro Lys Pro Leu Ser Pro Thr Ala Asp Glu
                2565                2570                2575    
Ser Ser Arg Ala Pro Phe Gln Tyr Thr Glu Gly Tyr Thr Thr Lys Gly
            2580                2585                2590        
Ser Gln Thr Met Thr Ser Ser Gly Ala Gln Lys Lys Val Lys Arg Thr
        2595                2600                2605            
Leu Pro Asn Pro Pro Pro Glu Glu Ile Ser Thr Gly Thr Gln Ser Thr
    2610                2615                2620                
Phe Ser Thr Met Gly Thr Val Ser Arg Arg Arg Ile Cys Arg Thr Asn
2625                2630                2635                2640
Thr Met Ala Arg Ala Lys Ile Leu Gln Asp Ile Asp Arg Glu Leu Asp
                2645                2650                2655    
Leu Val Glu Arg Glu Ser Ala Lys Leu Arg Lys Lys Gln Ala Glu Leu
            2660                2665                2670        
Asp Glu Glu Glu Lys Glu Ile Asp Ala Lys Leu Arg Tyr Leu Glu Met
        2675                2680                2685            
Gly Ile Asn Arg Arg Lys Glu Ala Leu Leu Lys Glu Arg Glu Lys Arg
    2690                2695                2700                
Glu Arg Ala Tyr Leu Gln Gly Val Ala Glu Asp Arg Asp Tyr Met Ser
2705                2710                2715                2720
Asp Ser Glu Val Ser Ser Thr Arg Pro Thr Arg Ile Glu Ser Gln His
                2725                2730                2735    
Gly Ile Glu Arg Pro Arg Thr Ala Pro Gln Thr Glu Phe Ser Gln Phe
            2740                2745                2750        
Ile Pro Pro Gln Thr Gln Thr Glu Ser Gln Leu Val Pro Pro Thr Ser
        2755                2760                2765            
Pro Tyr Thr Gln Tyr Gln Tyr Ser Ser Pro Ala Leu Pro Thr Gln Ala
    2770                2775                2780                
Pro Thr Ser Tyr Thr Gln Gln Ser His Phe Glu Gln Gln Thr Leu Tyr
2785                2790                2795                2800
His Gln Gln Val Ser Pro Tyr Gln Thr Gln Pro Thr Phe Gln Ala Val
                2805                2810                2815    
Ala Thr Met Ser Phe Thr Pro Gln Val Gln Pro Thr Pro Thr Pro Gln
            2820                2825                2830        
Pro Ser Tyr Gln Leu Pro Ser Gln Met Met Val Ile Gln Gln Lys Pro
        2835                2840                2845            
Arg Gln Thr Thr Leu Tyr Leu Glu Pro Lys Ile Thr Ser Asn Tyr Glu
    2850                2855                2860                
Val Ile Arg Asn Gln Pro Leu Met Ile Ala Pro Val Ser Thr Asp Asn
2865                2870                2875                2880
Thr Phe Ala Val Ser His Leu Gly Ser Lys Tyr Asn Ser Leu Asp Leu
                2885                2890                2895    
Arg Ile Gly Leu Glu Glu Arg Ser Ser Met Ala Ser Ser Pro Ile Ser
            2900                2905                2910        
Ser Ile Ser Ala Asp Ser Phe Tyr Ala Asp Ile Asp His His Thr Pro
        2915                2920                2925            
Arg Asn Tyr Val Leu Ile Asp Asp Ile Gly Glu Ile Thr Lys Gly Thr
    2930                2935                2940                
Ala Ala Leu Ser Thr Ala Phe Ser Leu His Glu Lys Asp Leu Ser Lys
2945                2950                2955                2960
Thr Asp Arg Leu Leu Arg Thr Thr Glu Thr Arg Arg Ser Gln Glu Val
                2965                2970                2975    
Thr Asp Phe Leu Ala Pro Leu Gln Ser Ser Ser Arg Leu His Ser Tyr
            2980                2985                2990        
Val Lys Ala Glu Glu Asp Pro Met Glu Asp Pro Tyr Glu Leu Lys Leu
        2995                3000                3005            
Leu Lys His Gln Ile Lys Gln Glu Phe Arg Arg Gly Thr Glu Ser Leu
    3010                3015                3020                
Asp His Leu Ala Gly Leu Ser His Tyr Tyr His Ala Asp Thr Ser Tyr
3025                3030                3035                3040
Arg His Phe Pro Lys Ser Glu Lys Tyr Ser Ile Ser Arg Leu Thr Leu
                3045                3050                3055    
Glu Lys Gln Ala Ala Lys Gln Leu Pro Ala Ala Ile Leu Tyr Gln Lys
            3060                3065                3070        
Gln Ser Lys His Lys Lys Ser Leu Ile Asp Pro Lys Met Ser Lys Phe
        3075                3080                3085            
Ser Pro Ile Gln Glu Ser Arg Asp Leu Glu Pro Asp Tyr Ser Ser Tyr
    3090                3095                3100                
Met Thr Ser Ser Thr Ser Ser Ile Gly Gly Ile Ser Ser Arg Ala Arg
3105                3110                3115                3120
Leu Leu Gln Asp Asp Ile Thr Phe Gly Leu Arg Lys Asn Ile Thr Asp
                3125                3130                3135    
Gln Gln Lys Phe Met Gly Ser Ser Leu Gly Thr Gly Leu Gly Thr Leu
            3140                3145                3150        
Gly Asn Thr Ile Arg Ser Ala Leu Gln Asp Glu Ala Asp Lys Pro Tyr
        3155                3160                3165            
Ser Ser Gly Ser Arg Ser Arg Pro Ser Ser Arg Pro Ser Ser Val Tyr
    3170                3175                3180                
Gly Leu Asp Leu Ser Ile Lys Arg Asp Ser Ser Ser Ser Ser Leu Arg
3185                3190                3195                3200
Leu Lys Ala Gln Glu Ala Glu Ala Leu Asp Val Ser Phe Ser His Ala
                3205                3210                3215    
Ser Ser Ser Ala Arg Thr Lys Pro Thr Ser Leu Pro Ile Ser Gln Ser
            3220                3225                3230        
Arg Gly Arg Ile Pro Ile Val Ala Gln Asn Ser Glu Glu Glu Ser Pro
        3235                3240                3245            
Leu Ser Pro Val Gly Gln Pro Met Gly Met Ala Arg Ala Ala Ala Gly
    3250                3255                3260                
Pro Leu Pro Pro Ile Ser Ala Asp Thr Arg Asp Gln Phe Gly Ser Ser
3265                3270                3275                3280
His Ser Leu Pro Glu Val Gln Gln His Met Arg Glu Glu Ser Arg Thr
                3285                3290                3295    
Arg Gly Tyr Asp Arg Asp Ile Ala Phe Ile Met Asp Asp Phe Gln His
            3300                3305                3310        
Ala Met Ser Asp Ser Glu Ala Tyr His Leu Arg Arg Glu Glu Thr Asp
        3315                3320                3325            
Trp Phe Asp Lys Pro Arg Glu Ser Arg Leu Glu Asn Gly His Gly Leu
    3330                3335                3340                
Asp Arg Lys Leu Pro Glu Arg Leu Val His Ser Arg Pro Leu Ser Gln
3345                3350                3355                3360
His Gln Glu Gln Ile Ile Gln Met Asn Gly Lys Thr Met His Tyr Ile
                3365                3370                3375    
Phe Pro His Ala Arg Ile Lys Ile Thr Arg Asp Ser Lys Asp His Thr
            3380                3385                3390        
Val Ser
        


<210> 530
<211> 459
<212> PRT
<213> Homo sapiens

<400> 530
Met Ala Ser Gly Val Glu Val Leu Arg Phe Gln Leu Pro Gly His Glu
 1               5                  10                  15      
Ala Ala Thr Leu Arg Asn Met Asn Gln Leu Arg Ala Glu Glu Arg Phe
            20                  25                  30          
Cys Asp Val Thr Ile Val Ala Asp Ser Leu Lys Phe Arg Gly His Lys
        35                  40                  45              
Val Ile Leu Ala Ala Cys Ser Pro Phe Leu Arg Asp Gln Phe Leu Leu
    50                  55                  60                  
Asn Pro Ser Ser Glu Leu Gln Val Ser Leu Met His Ser Ala Arg Ile
65                  70                  75                  80  
Val Ala Asp Leu Leu Leu Ser Cys Tyr Thr Gly Ala Leu Glu Phe Ala
                85                  90                  95      
Val Arg Asp Ile Val Asn Tyr Leu Thr Ala Ala Ser Tyr Leu Gln Met
            100                 105                 110         
Glu His Val Val Glu Lys Cys Arg Asn Ala Leu Ser Gln Phe Ile Glu
        115                 120                 125             
Pro Lys Ile Gly Leu Lys Glu Asp Gly Val Ser Glu Ala Ser Leu Val
    130                 135                 140                 
Ser Ser Ile Ser Ala Thr Lys Ser Leu Leu Pro Pro Ala Arg Thr Pro
145                 150                 155                 160 
Lys Pro Ala Pro Lys Pro Pro Pro Pro Pro Pro Leu Pro Pro Pro Leu
                165                 170                 175     
Leu Arg Pro Val Lys Leu Glu Phe Pro Leu Asp Glu Asp Leu Glu Leu
            180                 185                 190         
Lys Ala Glu Glu Glu Asp Glu Asp Glu Asp Glu Asp Val Ser Asp Ile
        195                 200                 205             
Cys Ile Val Lys Val Glu Ser Ala Leu Glu Val Ala His Arg Leu Lys
    210                 215                 220                 
Pro Pro Gly Gly Leu Gly Gly Gly Leu Gly Ile Gly Gly Ser Val Gly
225                 230                 235                 240 
Gly His Leu Gly Glu Leu Ala Gln Ser Ser Val Pro Pro Ser Thr Val
                245                 250                 255     
Ala Pro Pro Gln Gly Val Val Lys Ala Cys Tyr Ser Leu Ser Glu Asp
            260                 265                 270         
Ala Glu Gly Glu Gly Leu Leu Leu Ile Pro Gly Gly Arg Ala Ser Val
        275                 280                 285             
Gly Ala Thr Ser Gly Leu Val Glu Ala Ala Ala Val Ala Met Ala Ala
    290                 295                 300                 
Arg Gly Ala Gly Gly Ser Leu Gly Ala Gly Gly Ser Arg Gly Pro Leu
305                 310                 315                 320 
Pro Gly Gly Phe Ser Gly Gly Asn Pro Leu Lys Asn Ile Lys Cys Thr
                325                 330                 335     
Lys Cys Pro Glu Val Phe Gln Gly Val Glu Lys Leu Val Phe His Met
            340                 345                 350         
Arg Ala Gln His Phe Ile Phe Met Cys Pro Arg Cys Gly Lys Gln Phe
        355                 360                 365             
Asn His Ser Ser Asn Leu Asn Arg His Met Asn Val His Arg Gly Val
    370                 375                 380                 
Lys Ser His Ser Cys Gly Ile Cys Gly Lys Cys Phe Thr Gln Lys Ser
385                 390                 395                 400 
Thr Leu His Asp His Leu Asn Leu His Ser Gly Ala Arg Pro Tyr Arg
                405                 410                 415     
Cys Ser Tyr Cys Asp Val Arg Phe Ala His Lys Pro Ala Ile Arg Arg
            420                 425                 430         
His Leu Lys Glu Gln His Gly Lys Thr Thr Ala Glu Asn Val Leu Glu
        435                 440                 445             
Ala Ser Val Ala Glu Ile Asn Val Leu Ile Arg
    450                 455                 


<210> 531
<211> 334
<212> PRT
<213> Homo sapiens

<400> 531
Met Ala Thr Leu Lys Glu Lys Leu Ile Ala Pro Val Ala Glu Glu Glu
 1               5                  10                  15      
Ala Thr Val Pro Asn Asn Lys Ile Thr Val Val Gly Val Gly Gln Val
            20                  25                  30          
Gly Met Ala Cys Ala Ile Ser Ile Leu Gly Lys Ser Leu Ala Asp Glu
        35                  40                  45              
Leu Ala Leu Val Asp Val Leu Glu Asp Lys Leu Lys Gly Glu Met Met
    50                  55                  60                  
Asp Leu Gln His Gly Ser Leu Phe Leu Gln Thr Pro Lys Ile Val Ala
65                  70                  75                  80  
Asp Lys Asp Tyr Ser Val Thr Ala Asn Ser Lys Ile Val Val Val Thr
                85                  90                  95      
Ala Gly Val Arg Gln Gln Glu Gly Glu Ser Arg Leu Asn Leu Val Gln
            100                 105                 110         
Arg Asn Val Asn Val Phe Lys Phe Ile Ile Pro Gln Ile Val Lys Tyr
        115                 120                 125             
Ser Pro Asp Cys Ile Ile Ile Val Val Ser Asn Pro Val Asp Ile Leu
    130                 135                 140                 
Thr Tyr Val Thr Trp Lys Leu Ser Gly Leu Pro Lys His Arg Val Ile
145                 150                 155                 160 
Gly Ser Gly Cys Asn Leu Asp Ser Ala Arg Phe Arg Tyr Leu Met Ala
                165                 170                 175     
Glu Lys Leu Gly Ile His Pro Ser Ser Cys His Gly Trp Ile Leu Gly
            180                 185                 190         
Glu His Gly Asp Ser Ser Val Ala Val Trp Ser Gly Val Asn Val Ala
        195                 200                 205             
Gly Val Ser Leu Gln Glu Leu Asn Pro Glu Met Gly Thr Asp Asn Asp
    210                 215                 220                 
Ser Glu Asn Trp Lys Glu Val His Lys Met Val Val Glu Ser Ala Tyr
225                 230                 235                 240 
Glu Val Ile Lys Leu Lys Gly Tyr Thr Asn Trp Ala Ile Gly Leu Ser
                245                 250                 255     
Val Ala Asp Leu Ile Glu Ser Met Leu Lys Asn Leu Ser Arg Ile His
            260                 265                 270         
Pro Val Ser Thr Met Val Lys Gly Met Tyr Gly Ile Glu Asn Glu Val
        275                 280                 285             
Phe Leu Ser Leu Pro Cys Ile Leu Asn Ala Arg Gly Leu Thr Ser Val
    290                 295                 300                 
Ile Asn Gln Lys Leu Lys Asp Asp Glu Val Ala Gln Leu Lys Lys Ser
305                 310                 315                 320 
Ala Asp Thr Leu Trp Asp Ile Gln Lys Asp Leu Lys Asp Leu
                325                 330                 


<210> 532
<211> 114
<212> PRT
<213> Homo sapiens

<400> 532
Met Asn Val Leu Leu Gly Ser Val Val Ile Phe Ala Thr Phe Val Thr
 1               5                  10                  15      
Leu Cys Asn Ala Ser Cys Tyr Phe Ile Pro Asn Glu Gly Val Pro Gly
            20                  25                  30          
Asp Ser Thr Arg Lys Cys Met Asp Leu Lys Gly Asn Lys His Pro Ile
        35                  40                  45              
Asn Ser Glu Trp Gln Thr Asp Asn Cys Glu Thr Cys Thr Cys Tyr Glu
    50                  55                  60                  
Thr Glu Ile Ser Cys Cys Thr Leu Val Ser Thr Pro Val Gly Tyr Asp
65                  70                  75                  80  
Lys Asp Asn Cys Gln Arg Ile Phe Lys Lys Glu Asp Cys Lys Tyr Ile
                85                  90                  95      
Val Val Glu Lys Lys Asp Pro Lys Lys Thr Cys Ser Val Ser Glu Trp
            100                 105                 110         
Ile Ile
        


<210> 533
<211> 539
<212> PRT
<213> Homo sapiens

<400> 533
Met Ala Ala Ala Leu Arg Val Ala Ala Val Gly Ala Arg Leu Ser Val
 1               5                  10                  15      
Leu Ala Ser Gly Leu Arg Ala Ala Val Arg Ser Leu Cys Ser Gln Ala
            20                  25                  30          
Thr Ser Val Asn Glu Arg Ile Glu Asn Lys Arg Arg Thr Ala Leu Leu
        35                  40                  45              
Gly Gly Gly Gln Arg Arg Ile Asp Ala Gln His Lys Arg Gly Lys Leu
    50                  55                  60                  
Thr Ala Arg Glu Arg Ile Ser Leu Leu Leu Asp Pro Gly Ser Phe Val
65                  70                  75                  80  
Glu Ser Asp Met Phe Val Glu His Arg Cys Ala Asp Phe Gly Met Ala
                85                  90                  95      
Ala Asp Lys Asn Lys Phe Pro Gly Asp Ser Val Val Thr Gly Arg Gly
            100                 105                 110         
Arg Ile Asn Gly Arg Leu Val Tyr Val Phe Ser Gln Asp Phe Thr Val
        115                 120                 125             
Phe Gly Gly Ser Leu Ser Gly Ala His Ala Gln Lys Ile Cys Lys Ile
    130                 135                 140                 
Met Asp Gln Ala Ile Thr Val Gly Ala Pro Val Ile Gly Leu Asn Asp
145                 150                 155                 160 
Ser Gly Gly Ala Arg Ile Gln Glu Gly Val Glu Ser Leu Ala Gly Tyr
                165                 170                 175     
Ala Asp Ile Phe Leu Arg Asn Val Thr Ala Ser Gly Val Ile Pro Gln
            180                 185                 190         
Ile Ser Leu Ile Met Gly Pro Cys Ala Gly Gly Ala Val Tyr Ser Pro
        195                 200                 205             
Ala Leu Thr Asp Phe Thr Phe Met Val Lys Asp Thr Ser Tyr Leu Phe
    210                 215                 220                 
Ile Thr Gly Pro Asp Val Val Lys Ser Val Thr Asn Glu Asp Val Thr
225                 230                 235                 240 
Gln Glu Glu Leu Gly Gly Ala Lys Thr His Thr Thr Met Ser Gly Val
                245                 250                 255     
Ala His Arg Ala Phe Glu Asn Asp Val Asp Ala Leu Cys Asn Leu Arg
            260                 265                 270         
Asp Phe Phe Asn Tyr Leu Pro Leu Ser Ser Gln Asp Pro Ala Ser Val
        275                 280                 285             
Arg Glu Cys His Asp Pro Ser Asp Arg Leu Val Pro Glu Leu Asp Thr
    290                 295                 300                 
Ile Val Pro Leu Glu Ser Thr Lys Ala Tyr Asn Met Val Asp Ile Ile
305                 310                 315                 320 
His Ser Val Val Asp Glu Arg Glu Phe Phe Glu Ile Met Pro Asn Tyr
                325                 330                 335     
Ala Lys Asn Ile Ile Val Gly Phe Ala Arg Met Asn Gly Arg Thr Val
            340                 345                 350         
Gly Ile Val Gly Asn Gln Pro Lys Val Ala Ser Gly Cys Leu Asp Ile
        355                 360                 365             
Asn Ser Ser Val Lys Gly Ala Arg Phe Val Arg Phe Cys Asp Ala Phe
    370                 375                 380                 
Asn Ile Pro Leu Ile Thr Phe Val Asp Val Pro Gly Phe Leu Pro Gly
385                 390                 395                 400 
Thr Ala Gln Glu Tyr Gly Gly Ile Ile Arg His Gly Ala Lys Leu Leu
                405                 410                 415     
Tyr Ala Phe Ala Glu Ala Thr Val Pro Lys Val Thr Val Ile Thr Arg
            420                 425                 430         
Lys Ala Tyr Gly Gly Ala Tyr Asp Val Met Ser Ser Lys His Leu Cys
        435                 440                 445             
Gly Asp Thr Asn Tyr Ala Trp Pro Thr Ala Glu Ile Ala Val Met Gly
    450                 455                 460                 
Ala Lys Gly Ala Val Glu Ile Ile Phe Lys Gly His Glu Asn Val Glu
465                 470                 475                 480 
Ala Ala Gln Ala Glu Tyr Ile Glu Lys Phe Ala Asn Pro Phe Pro Ala
                485                 490                 495     
Ala Val Arg Gly Phe Val Asp Asp Ile Ile Gln Pro Ser Ser Thr Arg
            500                 505                 510         
Ala Arg Ile Cys Cys Asp Leu Asp Val Leu Ala Ser Lys Lys Val Gln
        515                 520                 525             
Arg Pro Trp Arg Lys His Ala Asn Ile Pro Leu
    530                 535                 


<210> 534
<211> 655
<212> PRT
<213> Homo sapiens

<400> 534
Met Gln Ala Ala Arg Met Ala Ala Ser Leu Gly Arg Gln Leu Leu Arg
 1               5                  10                  15      
Leu Gly Gly Gly Ser Ser Arg Leu Thr Ala Leu Leu Gly Gln Pro Arg
            20                  25                  30          
Pro Gly Pro Ala Arg Arg Pro Tyr Ala Gly Gly Ala Ala Gln Leu Ala
        35                  40                  45              
Leu Asp Lys Ser Asp Ser His Pro Ser Asp Ala Leu Thr Arg Lys Lys
    50                  55                  60                  
Pro Ala Lys Ala Glu Ser Lys Ser Phe Ala Val Gly Met Phe Lys Gly
65                  70                  75                  80  
Gln Leu Thr Thr Asp Gln Val Phe Pro Tyr Pro Ser Val Leu Asn Glu
                85                  90                  95      
Glu Gln Thr Gln Phe Leu Lys Glu Leu Val Glu Pro Val Ser Arg Phe
            100                 105                 110         
Phe Glu Glu Val Asn Asp Pro Ala Lys Asn Asp Ala Leu Glu Met Val
        115                 120                 125             
Glu Glu Thr Thr Trp Gln Gly Leu Lys Glu Leu Gly Ala Phe Gly Leu
    130                 135                 140                 
Gln Val Pro Ser Glu Leu Gly Gly Val Gly Leu Cys Asn Thr Gln Tyr
145                 150                 155                 160 
Ala Arg Leu Val Glu Ile Val Gly Met His Asp Leu Gly Val Gly Ile
                165                 170                 175     
Thr Leu Gly Ala His Gln Ser Ile Gly Phe Lys Gly Ile Leu Leu Phe
            180                 185                 190         
Gly Thr Lys Ala Gln Lys Glu Lys Tyr Leu Pro Lys Leu Ala Ser Gly
        195                 200                 205             
Glu Thr Val Ala Ala Phe Cys Leu Thr Glu Pro Ser Ser Gly Ser Asp
    210                 215                 220                 
Ala Ala Ser Ile Arg Thr Ser Ala Val Pro Ser Pro Cys Gly Lys Tyr
225                 230                 235                 240 
Tyr Thr Leu Asn Gly Ser Lys Leu Trp Ile Ser Asn Gly Gly Leu Ala
                245                 250                 255     
Asp Ile Phe Thr Val Phe Ala Lys Thr Pro Val Thr Asp Pro Ala Thr
            260                 265                 270         
Gly Ala Val Lys Glu Lys Ile Thr Ala Phe Val Val Glu Arg Gly Phe
        275                 280                 285             
Gly Gly Ile Thr His Gly Pro Pro Glu Lys Lys Met Gly Ile Lys Ala
    290                 295                 300                 
Ser Asn Thr Ala Glu Val Phe Phe Asp Gly Val Arg Val Pro Ser Glu
305                 310                 315                 320 
Asn Val Leu Gly Glu Val Gly Ser Gly Phe Lys Val Ala Met His Ile
                325                 330                 335     
Leu Asn Asn Gly Arg Phe Gly Met Ala Ala Ala Leu Ala Gly Thr Met
            340                 345                 350         
Arg Gly Ile Ile Ala Lys Ala Val Asp His Ala Thr Asn Arg Thr Gln
        355                 360                 365             
Phe Gly Glu Lys Ile His Asn Phe Gly Leu Ile Gln Glu Lys Leu Ala
    370                 375                 380                 
Arg Met Val Met Leu Gln Tyr Val Thr Glu Ser Met Ala Tyr Met Val
385                 390                 395                 400 
Ser Ala Asn Met Asp Gln Gly Ala Thr Asp Phe Gln Ile Glu Ala Ala
                405                 410                 415     
Ile Ser Lys Ile Phe Gly Ser Glu Ala Ala Trp Lys Val Thr Asp Glu
            420                 425                 430         
Cys Ile Gln Ile Met Gly Gly Met Gly Phe Met Lys Glu Pro Gly Val
        435                 440                 445             
Glu Arg Val Leu Arg Asp Leu Arg Ile Phe Arg Ile Phe Glu Gly Thr
    450                 455                 460                 
Asn Asp Ile Leu Arg Leu Phe Val Ala Leu Gln Gly Cys Met Asp Lys
465                 470                 475                 480 
Gly Lys Glu Leu Ser Gly Leu Gly Ser Ala Leu Lys Asn Pro Phe Gly
                485                 490                 495     
Asn Ala Gly Leu Leu Leu Gly Glu Ala Gly Lys Gln Leu Arg Arg Arg
            500                 505                 510         
Ala Gly Leu Gly Ser Gly Leu Ser Leu Ser Gly Leu Val His Pro Glu
        515                 520                 525             
Leu Ser Arg Ser Gly Glu Leu Ala Val Arg Ala Leu Glu Gln Phe Ala
    530                 535                 540                 
Thr Val Val Glu Ala Lys Leu Ile Lys His Lys Lys Gly Ile Val Asn
545                 550                 555                 560 
Glu Gln Phe Leu Leu Gln Arg Leu Ala Asp Gly Ala Ile Asp Leu Tyr
                565                 570                 575     
Ala Met Val Val Val Leu Ser Arg Ala Ser Arg Ser Leu Ser Glu Gly
            580                 585                 590         
His Pro Thr Ala Gln His Glu Lys Met Leu Cys Asp Thr Trp Cys Ile
        595                 600                 605             
Glu Ala Ala Ala Arg Ile Arg Glu Gly Met Ala Ala Leu Gln Ser Asp
    610                 615                 620                 
Pro Trp Gln Gln Glu Leu Tyr Arg Asn Phe Lys Ser Ile Ser Lys Ala
625                 630                 635                 640 
Leu Val Glu Arg Gly Gly Val Val Thr Ser Asn Pro Leu Gly Phe
                645                 650                 655 


<210> 535
<211> 99
<212> PRT
<213> Homo sapiens

<400> 535
Met Ser Thr Ala Gln Ser Leu Lys Ser Val Asp Tyr Glu Val Phe Gly
 1               5                  10                  15      
Arg Val Gln Gly Val Cys Phe Arg Met Tyr Thr Glu Asp Glu Ala Arg
            20                  25                  30          
Lys Ile Gly Val Val Gly Trp Val Lys Asn Thr Ser Lys Gly Thr Val
        35                  40                  45              
Thr Gly Gln Val Gln Gly Pro Glu Asp Lys Val Asn Ser Met Lys Ser
    50                  55                  60                  
Trp Leu Ser Lys Val Gly Ser Pro Ser Ser Arg Ile Asp Arg Thr Asn
65                  70                  75                  80  
Phe Ser Asn Glu Lys Thr Ile Ser Lys Leu Glu Tyr Ser Asn Phe Ser
                85                  90                  95      
Ile Arg Tyr
            


<210> 536
<211> 477
<212> PRT
<213> Homo sapiens

<400> 536
Met Gly Ala Gly Val Leu Val Leu Gly Ala Ser Glu Pro Gly Asn Leu
 1               5                  10                  15      
Ser Ser Ala Ala Pro Leu Pro Asp Gly Ala Ala Thr Ala Ala Arg Leu
            20                  25                  30          
Leu Val Pro Ala Ser Pro Pro Ala Ser Leu Leu Pro Pro Ala Ser Glu
        35                  40                  45              
Ser Pro Glu Pro Leu Ser Gln Gln Trp Thr Ala Gly Met Gly Leu Leu
    50                  55                  60                  
Met Ala Leu Ile Val Leu Leu Ile Val Ala Gly Asn Val Leu Val Ile
65                  70                  75                  80  
Val Ala Ile Ala Lys Thr Pro Arg Leu Gln Thr Leu Thr Asn Leu Phe
                85                  90                  95      
Ile Met Ser Leu Ala Ser Ala Asp Leu Val Met Gly Leu Leu Val Val
            100                 105                 110         
Pro Phe Gly Ala Thr Ile Val Val Trp Gly Arg Trp Glu Tyr Gly Ser
        115                 120                 125             
Phe Phe Cys Glu Leu Trp Thr Ser Val Asp Val Leu Cys Val Thr Ala
    130                 135                 140                 
Ser Ile Glu Thr Leu Cys Val Ile Ala Leu Asp Arg Tyr Leu Ala Ile
145                 150                 155                 160 
Thr Ser Pro Phe Arg Tyr Gln Ser Leu Leu Thr Arg Ala Arg Ala Arg
                165                 170                 175     
Gly Leu Val Cys Thr Val Trp Ala Ile Ser Ala Leu Val Ser Phe Leu
            180                 185                 190         
Pro Ile Leu Met His Trp Trp Arg Ala Glu Ser Asp Glu Ala Arg Arg
        195                 200                 205             
Cys Tyr Asn Asp Pro Lys Cys Cys Asp Phe Val Thr Asn Arg Ala Tyr
    210                 215                 220                 
Ala Ile Ala Ser Ser Val Val Ser Phe Tyr Val Pro Leu Cys Ile Met
225                 230                 235                 240 
Ala Phe Val Tyr Leu Arg Val Phe Arg Glu Ala Gln Lys Gln Val Lys
                245                 250                 255     
Lys Ile Asp Ser Cys Glu Arg Arg Phe Leu Gly Gly Pro Ala Arg Pro
            260                 265                 270         
Pro Ser Pro Ser Pro Ser Pro Val Pro Ala Pro Ala Pro Pro Pro Gly
        275                 280                 285             
Pro Pro Arg Pro Ala Ala Ala Ala Ala Thr Ala Pro Leu Ala Asn Gly
    290                 295                 300                 
Arg Ala Gly Lys Arg Arg Pro Ser Arg Leu Val Ala Leu Arg Glu Gln
305                 310                 315                 320 
Lys Ala Leu Lys Thr Leu Gly Ile Ile Met Gly Val Phe Thr Leu Cys
                325                 330                 335     
Trp Leu Pro Phe Phe Leu Ala Asn Val Val Lys Ala Phe His Arg Glu
            340                 345                 350         
Leu Val Pro Asp Arg Leu Phe Val Phe Phe Asn Trp Leu Gly Tyr Ala
        355                 360                 365             
Asn Ser Ala Phe Asn Pro Ile Ile Tyr Cys Arg Ser Pro Asp Phe Arg
    370                 375                 380                 
Lys Ala Phe Gln Gly Leu Leu Cys Cys Ala Arg Arg Ala Ala Arg Arg
385                 390                 395                 400 
Arg His Ala Thr His Gly Asp Arg Pro Arg Ala Ser Gly Cys Leu Ala
                405                 410                 415     
Arg Pro Gly Pro Pro Pro Ser Pro Gly Ala Ala Ser Asp Asp Asp Asp
            420                 425                 430         
Asp Asp Val Val Gly Ala Thr Pro Pro Ala Arg Leu Leu Glu Pro Trp
        435                 440                 445             
Ala Gly Cys Asn Gly Gly Ala Ala Ala Asp Ser Asp Ser Ser Leu Asp
    450                 455                 460                 
Glu Pro Cys Arg Pro Gly Phe Ala Ser Glu Ser Lys Val
465                 470                 475         


<210> 537
<211> 364
<212> PRT
<213> Homo sapiens

<400> 537
Met Pro Tyr Gln Tyr Pro Ala Leu Thr Pro Glu Gln Lys Lys Glu Leu
 1               5                  10                  15      
Ser Asp Ile Ala His Arg Ile Val Ala Pro Gly Lys Gly Ile Leu Ala
            20                  25                  30          
Ala Asp Glu Ser Thr Gly Ser Ile Ala Lys Arg Leu Gln Ser Ile Gly
        35                  40                  45              
Thr Glu Asn Thr Glu Glu Asn Arg Arg Phe Tyr Arg Gln Leu Leu Leu
    50                  55                  60                  
Thr Ala Asp Asp Arg Val Asn Pro Cys Ile Gly Gly Val Ile Leu Phe
65                  70                  75                  80  
His Glu Thr Leu Tyr Gln Lys Ala Asp Asp Gly Arg Pro Phe Pro Gln
                85                  90                  95      
Val Ile Lys Ser Lys Gly Gly Val Val Gly Ile Lys Val Asp Lys Gly
            100                 105                 110         
Val Val Pro Leu Ala Gly Thr Asn Gly Glu Thr Thr Thr Gln Gly Leu
        115                 120                 125             
Asp Gly Leu Ser Glu Arg Cys Ala Gln Tyr Lys Lys Asp Gly Ala Asp
    130                 135                 140                 
Phe Ala Lys Trp Arg Cys Val Leu Lys Ile Gly Glu His Thr Pro Ser
145                 150                 155                 160 
Ala Leu Ala Ile Met Glu Asn Ala Asn Val Leu Ala Arg Tyr Ala Ser
                165                 170                 175     
Ile Cys Gln Gln Asn Gly Ile Val Pro Ile Val Glu Pro Glu Ile Leu
            180                 185                 190         
Pro Asp Gly Asp His Asp Leu Lys Arg Cys Gln Tyr Val Thr Glu Lys
        195                 200                 205             
Val Leu Ala Ala Val Tyr Lys Ala Leu Ser Asp His His Ile Tyr Leu
    210                 215                 220                 
Glu Gly Thr Leu Leu Lys Pro Asn Met Val Thr Pro Gly His Ala Cys
225                 230                 235                 240 
Thr Gln Lys Phe Ser His Glu Glu Ile Ala Met Ala Thr Val Thr Ala
                245                 250                 255     
Leu Arg Arg Thr Val Pro Pro Ala Val Thr Gly Ile Thr Phe Leu Ser
            260                 265                 270         
Gly Gly Gln Ser Glu Glu Glu Ala Ser Ile Asn Leu Asn Ala Ile Asn
        275                 280                 285             
Lys Cys Pro Leu Leu Lys Pro Trp Ala Leu Thr Phe Ser Tyr Gly Arg
    290                 295                 300                 
Ala Leu Gln Ala Ser Ala Leu Lys Ala Trp Gly Gly Lys Lys Glu Asn
305                 310                 315                 320 
Leu Lys Ala Ala Gln Glu Glu Tyr Val Lys Arg Ala Leu Ala Asn Ser
                325                 330                 335     
Leu Ala Cys Gln Gly Lys Tyr Thr Pro Ser Gly Gln Ala Gly Ala Ala
            340                 345                 350         
Ala Ser Glu Ser Leu Phe Val Ser Asn His Ala Tyr
        355                 360                 


<210> 538
<211> 747
<212> PRT
<213> Homo sapiens

<400> 538
Met Pro Leu Phe Lys Leu Pro Ala Glu Glu Lys Gln Ile Asp Asp Ala
 1               5                  10                  15      
Met Arg Asn Phe Ala Glu Lys Val Phe Ala Ser Glu Val Lys Asp Glu
            20                  25                  30          
Gly Gly Arg Gln Glu Ile Ser Pro Phe Asp Val Asp Glu Ile Cys Pro
        35                  40                  45              
Ile Ser His His Glu Met Gln Ala His Ile Phe His Leu Glu Thr Leu
    50                  55                  60                  
Ser Thr Ser Thr Glu Ala Arg Arg Lys Lys Arg Phe Gln Gly Arg Lys
65                  70                  75                  80  
Thr Val Asn Leu Ser Ile Pro Leu Ser Glu Thr Ser Ser Thr Lys Leu
                85                  90                  95      
Ser His Ile Asp Glu Tyr Ile Ser Ser Ser Pro Thr Tyr Gln Thr Val
            100                 105                 110         
Pro Asp Phe Gln Arg Val Gln Ile Thr Gly Asp Tyr Ala Ser Gly Val
        115                 120                 125             
Thr Val Glu Asp Phe Glu Ile Val Cys Lys Gly Leu Tyr Arg Ala Leu
    130                 135                 140                 
Cys Ile Arg Glu Lys Tyr Met Gln Lys Ser Phe Gln Arg Phe Pro Lys
145                 150                 155                 160 
Thr Pro Ser Lys Tyr Leu Arg Asn Ile Asp Gly Glu Ala Trp Val Ala
                165                 170                 175     
Asn Glu Ser Phe Tyr Pro Val Phe Thr Pro Pro Val Lys Lys Gly Glu
            180                 185                 190         
Asp Pro Phe Arg Thr Asp Asn Leu Pro Glu Asn Leu Gly Tyr His Leu
        195                 200                 205             
Lys Met Lys Asp Gly Val Val Tyr Val Tyr Pro Asn Glu Ala Ala Val
    210                 215                 220                 
Ser Lys Asp Glu Pro Lys Pro Leu Pro Tyr Pro Asn Leu Asp Thr Phe
225                 230                 235                 240 
Leu Asp Asp Met Asn Phe Leu Leu Ala Leu Ile Ala Gln Gly Pro Val
                245                 250                 255     
Lys Thr Tyr Thr His Arg Arg Leu Lys Phe Leu Ser Ser Lys Phe Gln
            260                 265                 270         
Val His Gln Met Leu Asn Glu Met Asp Glu Leu Lys Glu Leu Lys Asn
        275                 280                 285             
Asn Pro His Arg Asp Phe Tyr Asn Cys Arg Lys Val Asp Thr His Ile
    290                 295                 300                 
His Ala Ala Ala Cys Met Asn Gln Lys His Leu Leu Arg Phe Ile Lys
305                 310                 315                 320 
Lys Ser Tyr Gln Ile Asp Ala Asp Arg Val Val Tyr Ser Thr Lys Glu
                325                 330                 335     
Lys Asn Leu Thr Leu Lys Glu Leu Phe Ala Lys Leu Lys Met His Pro
            340                 345                 350         
Tyr Asp Leu Thr Val Asp Ser Leu Asp Val His Ala Gly Arg Gln Thr
        355                 360                 365             
Phe Gln Arg Phe Asp Lys Phe Asn Asp Lys Tyr Asn Pro Val Gly Ala
    370                 375                 380                 
Ser Glu Leu Arg Asp Leu Tyr Leu Lys Thr Asp Asn Tyr Ile Asn Gly
385                 390                 395                 400 
Glu Tyr Phe Ala Thr Ile Ile Lys Glu Val Gly Ala Asp Leu Val Glu
                405                 410                 415     
Ala Lys Tyr Gln His Ala Glu Pro Arg Leu Ser Ile Tyr Gly Arg Ser
            420                 425                 430         
Pro Asp Glu Trp Ser Lys Leu Ser Ser Trp Phe Val Cys Asn Arg Ile
        435                 440                 445             
His Cys Pro Asn Met Thr Trp Met Ile Gln Val Pro Arg Ile Tyr Asp
    450                 455                 460                 
Val Phe Arg Ser Lys Asn Phe Leu Pro His Phe Gly Lys Met Leu Glu
465                 470                 475                 480 
Asn Ile Phe Met Pro Val Phe Glu Ala Thr Ile Asn Pro Gln Ala Asp
                485                 490                 495     
Pro Glu Leu Ser Val Phe Leu Lys His Ile Thr Gly Phe Asp Ser Val
            500                 505                 510         
Asp Asp Glu Ser Lys His Ser Gly His Met Phe Ser Ser Lys Ser Pro
        515                 520                 525             
Lys Pro Gln Glu Trp Thr Leu Glu Lys Asn Pro Ser Tyr Thr Tyr Tyr
    530                 535                 540                 
Ala Tyr Tyr Met Tyr Ala Asn Ile Met Val Leu Asn Ser Leu Arg Lys
545                 550                 555                 560 
Glu Arg Gly Met Asn Thr Phe Leu Phe Arg Pro His Cys Gly Glu Ala
                565                 570                 575     
Gly Ala Leu Thr His Leu Met Thr Ala Phe Met Ile Ala Asp Asp Ile
            580                 585                 590         
Ser His Gly Leu Asn Leu Lys Lys Ser Pro Val Leu Gln Tyr Leu Phe
        595                 600                 605             
Phe Leu Ala Gln Ile Pro Ile Ala Met Ser Pro Leu Ser Asn Asn Ser
    610                 615                 620                 
Leu Phe Leu Glu Tyr Ala Lys Asn Pro Phe Leu Asp Phe Leu Gln Lys
625                 630                 635                 640 
Gly Leu Met Ile Ser Leu Ser Thr Asp Asp Pro Met Gln Phe His Phe
                645                 650                 655     
Thr Lys Glu Pro Leu Met Glu Glu Tyr Ala Ile Ala Ala Gln Val Phe
            660                 665                 670         
Lys Leu Ser Thr Cys Asp Met Cys Glu Val Ala Arg Asn Ser Val Leu
        675                 680                 685             
Gln Cys Gly Ile Ser His Glu Glu Lys Val Lys Phe Leu Gly Asp Asn
    690                 695                 700                 
Tyr Leu Glu Glu Gly Pro Ala Gly Asn Asp Ile Arg Arg Thr Asn Val
705                 710                 715                 720 
Ala Gln Ile Arg Met Ala Tyr Arg Tyr Glu Thr Trp Cys Tyr Glu Leu
                725                 730                 735     
Asn Leu Ile Ala Glu Gly Leu Lys Ser Thr Glu
            740                 745         


<210> 539
<211> 505
<212> PRT
<213> Homo sapiens

<400> 539
Met Ser Tyr Pro Gly Tyr Pro Pro Pro Pro Gly Gly Tyr Pro Pro Ala
 1               5                  10                  15      
Ala Pro Gly Gly Gly Pro Trp Gly Gly Ala Ala Tyr Pro Pro Pro Pro
            20                  25                  30          
Ser Met Pro Pro Ile Gly Leu Asp Asn Val Ala Thr Tyr Ala Gly Gln
        35                  40                  45              
Phe Asn Gln Asp Tyr Leu Ser Gly Met Ala Ala Asn Met Ser Gly Thr
    50                  55                  60                  
Phe Gly Gly Ala Asn Met Pro Asn Leu Tyr Pro Gly Ala Pro Gly Ala
65                  70                  75                  80  
Gly Tyr Pro Pro Val Pro Pro Gly Gly Phe Gly Gln Pro Pro Ser Ala
                85                  90                  95      
Gln Gln Pro Val Pro Pro Tyr Gly Met Tyr Pro Pro Pro Gly Gly Asn
            100                 105                 110         
Pro Pro Ser Arg Met Pro Ser Tyr Pro Pro Tyr Pro Gly Ala Pro Val
        115                 120                 125             
Pro Gly Gln Pro Met Pro Pro Pro Gly Gln Gln Pro Pro Gly Ala Tyr
    130                 135                 140                 
Pro Gly Gln Pro Pro Val Thr Tyr Pro Gly Gln Pro Pro Val Pro Leu
145                 150                 155                 160 
Pro Gly Gln Gln Gln Pro Val Pro Ser Tyr Pro Gly Tyr Pro Gly Ser
                165                 170                 175     
Gly Thr Val Thr Pro Ala Val Pro Pro Thr Gln Phe Gly Ser Arg Gly
            180                 185                 190         
Thr Ile Thr Asp Ala Pro Gly Phe Asp Pro Leu Arg Asp Ala Glu Val
        195                 200                 205             
Leu Arg Lys Ala Met Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Ile
    210                 215                 220                 
Asp Cys Leu Gly Ser Arg Ser Asn Lys Gln Arg Gln Gln Ile Leu Leu
225                 230                 235                 240 
Ser Phe Lys Thr Ala Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser
                245                 250                 255     
Glu Leu Ser Gly Asn Phe Glu Lys Thr Ile Leu Ala Leu Met Lys Thr
            260                 265                 270         
Pro Val Leu Phe Asp Ile Tyr Glu Ile Lys Glu Ala Ile Lys Gly Val
        275                 280                 285             
Gly Thr Asp Glu Ala Cys Leu Ile Glu Ile Leu Ala Ser Arg Ser Asn
    290                 295                 300                 
Glu His Ile Arg Glu Leu Asn Arg Ala Tyr Lys Ala Glu Phe Lys Lys
305                 310                 315                 320 
Thr Leu Glu Glu Ala Ile Arg Ser Asp Thr Ser Gly His Phe Gln Arg
                325                 330                 335     
Leu Leu Ile Ser Leu Ser Gln Gly Asn Arg Asp Glu Ser Thr Asn Val
            340                 345                 350         
Asp Met Ser Leu Ala Gln Arg Asp Ala Gln Glu Leu Tyr Ala Ala Gly
        355                 360                 365             
Glu Asn Arg Leu Gly Thr Asp Glu Ser Lys Phe Asn Ala Val Leu Cys
    370                 375                 380                 
Ser Arg Ser Arg Ala His Leu Val Ala Val Phe Asn Glu Tyr Gln Arg
385                 390                 395                 400 
Met Thr Gly Arg Asp Ile Glu Lys Ser Ile Cys Arg Glu Met Ser Gly
                405                 410                 415     
Asp Leu Glu Glu Gly Met Leu Ala Val Val Lys Cys Leu Lys Asn Thr
            420                 425                 430         
Pro Ala Phe Phe Ala Glu Arg Leu Asn Lys Ala Met Arg Gly Ala Gly
        435                 440                 445             
Thr Lys Asp Arg Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Thr
    450                 455                 460                 
Asp Leu Leu Asp Ile Arg Ser Glu Tyr Lys Arg Met Tyr Gly Lys Ser
465                 470                 475                 480 
Leu Tyr His Asp Ile Ser Gly Asp Thr Ser Gly Asp Tyr Arg Lys Ile
                485                 490                 495     
Leu Leu Lys Ile Cys Gly Gly Asn Asp
            500                 505 


<210> 540
<211> 1417
<212> PRT
<213> Homo sapiens

<400> 540
Met Ala Ala Val Pro Gln Asn Asn Leu Gln Glu Gln Leu Glu Arg His
 1               5                  10                  15      
Ser Ala Arg Thr Leu Asn Asn Lys Leu Ser Leu Ser Lys Pro Lys Phe
            20                  25                  30          
Ser Gly Phe Thr Phe Lys Lys Lys Thr Ser Ser Asp Asn Asn Val Ser
        35                  40                  45              
Val Thr Asn Val Ser Val Ala Lys Thr Pro Val Leu Arg Asn Lys Asp
    50                  55                  60                  
Val Asn Val Thr Glu Asp Phe Ser Phe Ser Glu Pro Leu Pro Asn Thr
65                  70                  75                  80  
Thr Asn Gln Gln Arg Val Lys Asp Phe Phe Lys Asn Ala Pro Ala Gly
                85                  90                  95      
Gln Glu Thr Gln Arg Gly Gly Ser Lys Ser Leu Leu Pro Asp Phe Leu
            100                 105                 110         
Gln Thr Pro Lys Glu Val Val Cys Thr Thr Gln Asn Thr Pro Thr Val
        115                 120                 125             
Lys Lys Ser Arg Asp Thr Ala Leu Lys Lys Leu Glu Phe Ser Ser Ser
    130                 135                 140                 
Pro Asp Ser Leu Ser Thr Ile Asn Asp Trp Asp Asp Met Asp Asp Phe
145                 150                 155                 160 
Asp Thr Ser Glu Thr Ser Lys Ser Phe Val Thr Pro Pro Gln Ser His
                165                 170                 175     
Phe Val Arg Val Ser Thr Ala Gln Lys Ser Lys Lys Gly Lys Arg Asn
            180                 185                 190         
Phe Phe Lys Ala Gln Leu Tyr Thr Thr Asn Thr Val Lys Thr Asp Leu
        195                 200                 205             
Pro Pro Pro Ser Ser Glu Ser Glu Gln Ile Asp Leu Thr Glu Glu Gln
    210                 215                 220                 
Lys Asp Asp Ser Glu Trp Leu Ser Ser Asp Val Ile Cys Ile Asp Asp
225                 230                 235                 240 
Gly Pro Ile Ala Glu Val His Ile Asn Glu Asp Ala Gln Glu Ser Asp
                245                 250                 255     
Ser Leu Lys Thr His Leu Glu Asp Glu Arg Asp Asn Ser Glu Lys Lys
            260                 265                 270         
Lys Asn Leu Glu Glu Ala Glu Leu His Ser Thr Glu Lys Val Pro Cys
        275                 280                 285             
Ile Glu Phe Asp Asp Asp Asp Tyr Asp Thr Asp Phe Val Pro Pro Ser
    290                 295                 300                 
Pro Glu Glu Ile Ile Ser Ala Ser Ser Ser Ser Ser Lys Cys Leu Ser
305                 310                 315                 320 
Thr Leu Lys Asp Leu Asp Thr Ser Asp Arg Lys Glu Asp Val Leu Ser
                325                 330                 335     
Thr Ser Lys Asp Leu Leu Ser Lys Pro Glu Lys Met Ser Met Gln Glu
            340                 345                 350         
Leu Asn Pro Glu Thr Ser Thr Asp Cys Asp Ala Arg Gln Ile Ser Leu
        355                 360                 365             
Gln Gln Gln Leu Ile His Val Met Glu His Ile Cys Lys Leu Ile Asp
    370                 375                 380                 
Thr Ile Pro Asp Asp Lys Leu Lys Leu Leu Asp Cys Gly Asn Glu Leu
385                 390                 395                 400 
Leu Gln Gln Arg Asn Ile Arg Arg Lys Leu Leu Thr Glu Val Asp Phe
                405                 410                 415     
Asn Lys Ser Asp Ala Ser Leu Leu Gly Ser Leu Trp Arg Tyr Arg Pro
            420                 425                 430         
Asp Ser Leu Asp Gly Pro Met Glu Gly Asp Ser Cys Pro Thr Gly Asn
        435                 440                 445             
Ser Met Lys Glu Leu Asn Phe Ser His Leu Pro Ser Asn Ser Val Ser
    450                 455                 460                 
Pro Gly Asp Cys Leu Leu Thr Thr Thr Leu Gly Lys Thr Gly Phe Ser
465                 470                 475                 480 
Ala Thr Arg Lys Asn Leu Phe Glu Arg Pro Leu Phe Asn Thr His Leu
                485                 490                 495     
Gln Lys Ser Phe Val Ser Ser Asn Trp Ala Glu Thr Pro Arg Leu Gly
            500                 505                 510         
Lys Lys Asn Glu Ser Ser Tyr Phe Pro Gly Asn Val Leu Thr Ser Thr
        515                 520                 525             
Ala Val Lys Asp Gln Asn Lys His Thr Ala Ser Ile Asn Asp Leu Glu
    530                 535                 540                 
Arg Glu Thr Gln Pro Ser Tyr Asp Ile Asp Asn Phe Asp Ile Asp Asp
545                 550                 555                 560 
Phe Asp Asp Asp Asp Asp Trp Glu Asp Ile Met His Asn Leu Ala Ala
                565                 570                 575     
Ser Lys Ser Ser Thr Ala Ala Tyr Gln Pro Ile Lys Glu Gly Arg Pro
            580                 585                 590         
Ile Lys Ser Val Ser Glu Arg Leu Ser Ser Ala Lys Thr Asp Cys Leu
        595                 600                 605             
Pro Val Ser Ser Thr Ala Gln Asn Ile Asn Phe Ser Glu Ser Ile Gln
    610                 615                 620                 
Asn Tyr Thr Asp Lys Ser Ala Gln Asn Leu Ala Ser Arg Asn Leu Lys
625                 630                 635                 640 
His Glu Arg Phe Gln Ser Leu Ser Phe Pro His Thr Lys Glu Met Met
                645                 650                 655     
Lys Ile Phe His Lys Lys Phe Gly Leu His Asn Phe Arg Thr Asn Gln
            660                 665                 670         
Leu Glu Ala Ile Asn Ala Ala Leu Leu Gly Glu Asp Cys Phe Ile Leu
        675                 680                 685             
Met Pro Thr Gly Gly Gly Lys Ser Leu Cys Tyr Gln Leu Pro Ala Cys
    690                 695                 700                 
Val Ser Pro Gly Val Thr Val Val Ile Ser Pro Leu Arg Ser Leu Ile
705                 710                 715                 720 
Val Asp Gln Val Gln Lys Leu Thr Ser Leu Asp Ile Pro Ala Thr Tyr
                725                 730                 735     
Leu Thr Gly Asp Lys Thr Asp Ser Glu Ala Thr Asn Ile Tyr Leu Gln
            740                 745                 750         
Leu Ser Lys Lys Asp Pro Ile Ile Lys Leu Leu Tyr Val Thr Pro Glu
        755                 760                 765             
Lys Ile Cys Ala Ser Asn Arg Leu Ile Ser Thr Leu Glu Asn Leu Tyr
    770                 775                 780                 
Glu Arg Lys Leu Leu Ala Arg Phe Val Ile Asp Glu Ala His Cys Val
785                 790                 795                 800 
Ser Gln Trp Gly His Asp Phe Arg Gln Asp Tyr Lys Arg Met Asn Met
                805                 810                 815     
Leu Arg Gln Lys Phe Pro Ser Val Pro Val Met Ala Leu Thr Ala Thr
            820                 825                 830         
Ala Asn Pro Arg Val Gln Lys Asp Ile Leu Thr Gln Leu Lys Ile Leu
        835                 840                 845             
Arg Pro Gln Val Phe Ser Met Ser Phe Asn Arg His Asn Leu Lys Tyr
    850                 855                 860                 
Tyr Val Leu Pro Lys Lys Pro Lys Lys Val Ala Phe Asp Cys Leu Glu
865                 870                 875                 880 
Trp Ile Arg Lys His His Pro Tyr Asp Ser Gly Ile Ile Tyr Cys Leu
                885                 890                 895     
Ser Arg Arg Glu Cys Asp Thr Met Ala Asp Thr Leu Gln Arg Asp Gly
            900                 905                 910         
Leu Ala Ala Leu Ala Tyr His Ala Gly Leu Ser Asp Ser Ala Arg Asp
        915                 920                 925             
Glu Val Gln Gln Lys Trp Ile Asn Gln Asp Gly Cys Gln Val Ile Cys
    930                 935                 940                 
Ala Thr Ile Ala Phe Gly Met Gly Ile Asp Lys Pro Asp Val Arg Phe
945                 950                 955                 960 
Val Ile His Ala Ser Leu Pro Lys Ser Val Glu Gly Tyr Tyr Gln Glu
                965                 970                 975     
Ser Gly Arg Ala Gly Arg Asp Gly Glu Ile Ser His Cys Leu Leu Phe
            980                 985                 990         
Tyr Thr Tyr His Asp Val Thr Arg Leu Lys Arg Leu Ile Met Met Glu
        995                 1000                1005            
Lys Asp Gly Asn His His Thr Arg Glu Thr His Phe Asn Asn Leu Tyr
    1010                1015                1020                
Ser Met Val His Tyr Cys Glu Asn Ile Thr Glu Cys Arg Arg Ile Gln
1025                1030                1035                1040
Leu Leu Ala Tyr Phe Gly Glu Asn Gly Phe Asn Pro Asp Phe Cys Lys
                1045                1050                1055    
Lys His Pro Asp Val Ser Cys Asp Asn Cys Cys Lys Thr Lys Asp Tyr
            1060                1065                1070        
Lys Thr Arg Asp Val Thr Asp Asp Val Lys Ser Ile Val Arg Phe Val
        1075                1080                1085            
Gln Glu His Ser Ser Ser Gln Gly Met Arg Asn Ile Lys His Val Gly
    1090                1095                1100                
Pro Ser Gly Arg Phe Thr Met Asn Met Leu Val Asp Ile Phe Leu Gly
1105                1110                1115                1120
Ser Lys Ser Ala Lys Ile Gln Ser Gly Ile Phe Gly Lys Gly Ser Ala
                1125                1130                1135    
Tyr Ser Arg His Asn Ala Glu Arg Leu Phe Lys Lys Leu Ile Leu Asp
            1140                1145                1150        
Lys Ile Leu Asp Glu Asp Leu Tyr Ile Asn Ala Asn Asp Gln Ala Ile
        1155                1160                1165            
Ala Tyr Val Met Leu Gly Asn Lys Ala Gln Thr Val Leu Asn Gly Asn
    1170                1175                1180                
Leu Lys Val Asp Phe Met Glu Thr Glu Asn Ser Ser Ser Val Lys Lys
1185                1190                1195                1200
Gln Lys Ala Leu Val Ala Lys Val Ser Gln Arg Glu Glu Met Val Lys
                1205                1210                1215    
Lys Cys Leu Gly Glu Leu Thr Glu Val Cys Lys Ser Leu Gly Lys Val
            1220                1225                1230        
Phe Gly Val His Tyr Phe Asn Ile Phe Asn Thr Val Thr Leu Lys Lys
        1235                1240                1245            
Leu Ala Glu Ser Leu Ser Ser Asp Pro Glu Val Leu Leu Gln Ile Asp
    1250                1255                1260                
Gly Val Thr Glu Asp Lys Leu Glu Lys Tyr Gly Ala Glu Val Ile Ser
1265                1270                1275                1280
Val Leu Gln Lys Tyr Ser Glu Trp Thr Ser Pro Ala Glu Asp Ser Ser
                1285                1290                1295    
Pro Gly Ile Ser Leu Ser Ser Ser Arg Gly Pro Gly Arg Ser Ala Ala
            1300                1305                1310        
Glu Glu Leu Asp Glu Glu Ile Pro Val Ser Ser His Tyr Phe Ala Ser
        1315                1320                1325            
Lys Thr Arg Asn Glu Arg Lys Arg Lys Lys Met Pro Ala Ser Gln Arg
    1330                1335                1340                
Ser Lys Arg Arg Lys Thr Ala Ser Ser Gly Ser Lys Ala Lys Gly Gly
1345                1350                1355                1360
Ser Ala Thr Cys Arg Lys Ile Ser Ser Lys Thr Lys Ser Ser Ser Ile
                1365                1370                1375    
Ile Gly Ser Ser Ser Ala Ser His Thr Ser Gln Ala Thr Ser Gly Ala
            1380                1385                1390        
Asn Ser Lys Leu Gly Ile Met Ala Pro Pro Lys Pro Ile Asn Arg Pro
        1395                1400                1405            
Phe Leu Lys Pro Ser Tyr Ala Phe Ser
    1410                1415        


<210> 541
<211> 301
<212> PRT
<213> Homo sapiens

<400> 541
Met Ala Asp Gln Pro Lys Pro Ile Ser Pro Leu Lys Asn Leu Leu Ala
 1               5                  10                  15      
Gly Gly Phe Gly Gly Val Cys Leu Val Phe Val Gly His Pro Leu Asp
            20                  25                  30          
Thr Val Lys Val Arg Leu Gln Thr Gln Pro Pro Ser Leu Pro Gly Gln
        35                  40                  45              
Pro Pro Met Tyr Ser Gly Thr Phe Asp Cys Phe Arg Lys Thr Leu Phe
    50                  55                  60                  
Arg Glu Gly Ile Thr Gly Leu Tyr Arg Gly Met Ala Ala Pro Ile Ile
65                  70                  75                  80  
Gly Val Thr Pro Met Phe Ala Val Cys Phe Phe Gly Phe Gly Leu Gly
                85                  90                  95      
Lys Lys Leu Gln Gln Lys His Pro Glu Asp Val Leu Ser Tyr Pro Gln
            100                 105                 110         
Leu Phe Ala Ala Gly Met Leu Ser Gly Val Phe Thr Thr Gly Ile Met
        115                 120                 125             
Thr Pro Gly Glu Arg Ile Lys Cys Leu Leu Gln Ile Gln Ala Ser Ser
    130                 135                 140                 
Gly Glu Ser Lys Tyr Thr Gly Thr Leu Asp Cys Ala Lys Lys Leu Tyr
145                 150                 155                 160 
Gln Glu Phe Gly Ile Arg Gly Ile Tyr Lys Gly Thr Val Leu Thr Leu
                165                 170                 175     
Met Arg Asp Val Pro Ala Ser Gly Met Tyr Phe Met Thr Tyr Glu Trp
            180                 185                 190         
Leu Lys Asn Ile Phe Thr Pro Glu Gly Lys Arg Val Ser Glu Leu Ser
        195                 200                 205             
Ala Pro Arg Ile Leu Val Ala Gly Gly Ile Ala Gly Ile Phe Asn Trp
    210                 215                 220                 
Ala Val Ala Ile Pro Pro Asp Val Leu Lys Ser Arg Phe Gln Thr Ala
225                 230                 235                 240 
Pro Pro Gly Lys Tyr Pro Asn Gly Phe Arg Asp Val Leu Arg Glu Leu
                245                 250                 255     
Ile Arg Asp Glu Gly Val Thr Ser Leu Tyr Lys Gly Phe Asn Ala Val
            260                 265                 270         
Met Ile Arg Ala Phe Pro Ala Asn Ala Ala Cys Phe Leu Gly Phe Glu
        275                 280                 285             
Val Ala Met Lys Phe Leu Asn Trp Ala Thr Pro Asn Leu
    290                 295                 300     


<210> 542
<211> 301
<212> PRT
<213> Homo sapiens

<400> 542
Met Ala Asp Gln Pro Lys Pro Ile Ser Pro Leu Lys Asn Leu Leu Ala
 1               5                  10                  15      
Gly Gly Phe Gly Gly Val Cys Leu Val Phe Val Gly His Pro Leu Asp
            20                  25                  30          
Thr Val Lys Val Arg Leu Gln Thr Gln Pro Pro Ser Leu Pro Gly Gln
        35                  40                  45              
Pro Pro Met Tyr Ser Gly Thr Phe Asp Cys Phe Arg Lys Thr Leu Phe
    50                  55                  60                  
Arg Glu Gly Ile Thr Gly Leu Tyr Arg Gly Met Ala Ala Pro Ile Ile
65                  70                  75                  80  
Gly Val Thr Pro Met Phe Ala Val Cys Phe Phe Gly Phe Gly Leu Gly
                85                  90                  95      
Lys Lys Leu Gln Gln Lys His Pro Glu Asp Val Leu Ser Tyr Pro Gln
            100                 105                 110         
Leu Phe Ala Ala Gly Met Leu Ser Gly Val Phe Thr Thr Gly Ile Met
        115                 120                 125             
Thr Pro Gly Glu Arg Ile Lys Cys Leu Leu Gln Ile Gln Ala Ser Ser
    130                 135                 140                 
Gly Glu Ser Lys Tyr Thr Gly Thr Leu Asp Cys Ala Lys Lys Leu Tyr
145                 150                 155                 160 
Gln Glu Phe Gly Ile Arg Gly Ile Tyr Lys Gly Thr Val Leu Thr Leu
                165                 170                 175     
Met Arg Asp Val Pro Ala Ser Gly Met Tyr Phe Met Thr Tyr Glu Trp
            180                 185                 190         
Leu Lys Asn Ile Phe Thr Pro Glu Gly Lys Arg Val Ser Glu Leu Ser
        195                 200                 205             
Ala Pro Arg Ile Leu Val Ala Gly Gly Ile Ala Gly Ile Phe Asn Trp
    210                 215                 220                 
Ala Val Ala Ile Pro Pro Asp Val Leu Lys Ser Arg Phe Gln Thr Ala
225                 230                 235                 240 
Pro Pro Gly Lys Tyr Pro Asn Gly Phe Arg Asp Val Leu Arg Glu Leu
                245                 250                 255     
Ile Arg Asp Glu Gly Val Thr Ser Leu Tyr Lys Gly Phe Asn Ala Val
            260                 265                 270         
Met Ile Arg Ala Phe Pro Ala Asn Ala Ala Cys Phe Leu Gly Phe Glu
        275                 280                 285             
Val Ala Met Lys Phe Leu Asn Trp Ala Thr Pro Asn Leu
    290                 295                 300     


<210> 543
<211> 399
<212> PRT
<213> Homo sapiens

<400> 543
Met Lys Arg Thr His Leu Phe Ile Val Gly Ile Tyr Phe Leu Ser Ser
 1               5                  10                  15      
Cys Arg Ala Glu Glu Gly Leu Asn Phe Pro Thr Tyr Asp Gly Lys Asp
            20                  25                  30          
Arg Val Val Ser Leu Ser Glu Lys Asn Phe Lys Gln Val Leu Lys Lys
        35                  40                  45              
Tyr Asp Leu Leu Cys Leu Tyr Tyr His Glu Pro Val Ser Ser Asp Lys
    50                  55                  60                  
Val Thr Pro Lys Gln Phe Gln Leu Lys Glu Ile Val Leu Glu Leu Val
65                  70                  75                  80  
Ala Gln Val Leu Glu His Lys Ala Ile Gly Phe Val Met Val Asp Ala
                85                  90                  95      
Lys Lys Glu Ala Lys Leu Ala Lys Lys Leu Gly Phe Asp Glu Glu Gly
            100                 105                 110         
Ser Leu Tyr Ile Leu Lys Gly Asp Arg Thr Ile Glu Phe Asp Gly Glu
        115                 120                 125             
Phe Ala Ala Asp Val Leu Val Glu Phe Leu Leu Asp Leu Ile Glu Asp
    130                 135                 140                 
Pro Val Glu Ile Ile Ser Ser Lys Leu Glu Val Gln Ala Phe Glu Arg
145                 150                 155                 160 
Ile Glu Asp Tyr Ile Lys Leu Ile Gly Phe Phe Lys Ser Glu Asp Ser
                165                 170                 175     
Glu Tyr Tyr Lys Ala Phe Glu Glu Ala Ala Glu His Phe Gln Pro Tyr
            180                 185                 190         
Ile Lys Phe Phe Ala Thr Phe Asp Lys Gly Val Ala Lys Lys Leu Ser
        195                 200                 205             
Leu Lys Met Asn Glu Val Asp Phe Tyr Glu Pro Phe Met Asp Glu Pro
    210                 215                 220                 
Ile Ala Ile Pro Asn Lys Pro Tyr Thr Glu Glu Glu Leu Val Glu Phe
225                 230                 235                 240 
Val Lys Glu His Gln Arg Pro Thr Leu Arg Arg Leu Arg Pro Glu Glu
                245                 250                 255     
Met Phe Glu Thr Trp Glu Asp Asp Leu Asn Gly Ile His Ile Val Ala
            260                 265                 270         
Phe Ala Glu Lys Ser Asp Pro Asp Gly Tyr Glu Phe Leu Glu Ile Leu
        275                 280                 285             
Lys Gln Val Ala Arg Asp Asn Thr Asp Asn Pro Asp Leu Ser Ile Leu
    290                 295                 300                 
Trp Ile Asp Pro Asp Asp Phe Pro Leu Leu Val Ala Tyr Trp Glu Lys
305                 310                 315                 320 
Thr Phe Lys Ile Asp Leu Phe Arg Pro Gln Ile Gly Val Val Asn Val
                325                 330                 335     
Thr Asp Ala Asp Ser Val Trp Met Glu Ile Pro Asp Asp Asp Asp Leu
            340                 345                 350         
Pro Thr Ala Glu Glu Leu Glu Asp Trp Ile Glu Asp Val Leu Ser Gly
        355                 360                 365             
Lys Ile Asn Thr Glu Asp Asp Asp Glu Asp Asp Asp Asp Asp Asp Asn
    370                 375                 380                 
Ser Asp Glu Glu Asp Asn Asp Asp Ser Asp Asp Asp Asp Asp Glu
385                 390                 395                 


<210> 544
<211> 305
<212> PRT
<213> Homo sapiens

<400> 544
Met Asp Met Phe Gln Lys Val Glu Lys Ile Gly Glu Gly Thr Tyr Gly
 1               5                  10                  15      
Val Val Tyr Lys Ala Lys Asn Arg Glu Thr Gly Gln Leu Val Ala Leu
            20                  25                  30          
Lys Lys Ile Arg Leu Asp Leu Glu Met Glu Gly Val Pro Ser Thr Ala
        35                  40                  45              
Ile Arg Glu Ile Ser Leu Leu Lys Glu Leu Lys His Pro Asn Ile Val
    50                  55                  60                  
Arg Leu Leu Asp Val Val His Asn Glu Arg Lys Leu Tyr Leu Val Phe
65                  70                  75                  80  
Glu Phe Leu Ser Gln Asp Leu Lys Lys Tyr Met Asp Ser Thr Pro Gly
                85                  90                  95      
Ser Glu Leu Pro Leu His Leu Ile Lys Ser Tyr Leu Phe Gln Leu Leu
            100                 105                 110         
Gln Gly Val Ser Phe Cys His Ser His Arg Val Ile His Arg Asp Leu
        115                 120                 125             
Lys Pro Gln Asn Leu Leu Ile Asn Glu Leu Gly Ala Ile Lys Leu Ala
    130                 135                 140                 
Asp Phe Gly Leu Ala Arg Ala Phe Gly Val Pro Leu Arg Thr Tyr Thr
145                 150                 155                 160 
His Glu Val Val Thr Leu Trp Tyr Arg Ala Pro Glu Ile Leu Leu Gly
                165                 170                 175     
Ser Lys Phe Tyr Thr Thr Ala Val Asp Ile Trp Ser Ile Gly Cys Ile
            180                 185                 190         
Phe Ala Glu Met Val Thr Arg Lys Ala Leu Phe Pro Gly Asp Ser Glu
        195                 200                 205             
Ile Asp Gln Leu Phe Arg Ile Phe Arg Met Leu Gly Thr Pro Ser Glu
    210                 215                 220                 
Asp Thr Trp Pro Gly Val Thr Gln Leu Pro Asp Tyr Lys Gly Ser Phe
225                 230                 235                 240 
Pro Lys Trp Thr Arg Lys Gly Leu Glu Glu Ile Val Pro Asn Leu Glu
                245                 250                 255     
Pro Glu Gly Arg Asp Leu Leu Met Gln Leu Leu Gln Tyr Asp Pro Ser
            260                 265                 270         
Gln Arg Ile Thr Ala Lys Thr Ala Leu Ala His Pro Tyr Phe Ser Ser
        275                 280                 285             
Pro Glu Pro Ser Pro Ala Ala Arg Gln Tyr Val Leu Gln Arg Phe Arg
    290                 295                 300                 
His
305 


<210> 545
<211> 1944
<212> PRT
<213> Homo sapiens

<400> 545
Met Lys Ala Ala Asp Thr Val Ile Leu Trp Ala Arg Ser Lys Asn Asp
 1               5                  10                  15      
Gln Leu Arg Ile Ser Phe Pro Pro Gly Leu Cys Trp Gly Asp Arg Met
            20                  25                  30          
Pro Asp Lys Asp Asp Ile Arg Leu Leu Pro Ser Ala Leu Gly Val Lys
        35                  40                  45              
Lys Arg Lys Arg Gly Pro Lys Lys Gln Lys Glu Asn Lys Pro Gly Lys
    50                  55                  60                  
Pro Arg Lys Arg Lys Lys Arg Asp Ser Glu Glu Glu Phe Gly Ser Glu
65                  70                  75                  80  
Arg Asp Glu Tyr Arg Glu Lys Ser Glu Ser Gly Gly Ser Glu Tyr Gly
                85                  90                  95      
Thr Gly Pro Gly Arg Lys Arg Arg Arg Lys His Arg Glu Lys Lys Glu
            100                 105                 110         
Lys Lys Thr Lys Arg Arg Lys Lys Gly Glu Gly Asp Gly Gly Gln Lys
        115                 120                 125             
Gln Val Glu Gln Lys Ser Ser Ala Thr Leu Leu Leu Thr Trp Gly Leu
    130                 135                 140                 
Glu Asp Val Glu His Val Phe Ser Glu Glu Asp Tyr His Thr Leu Thr
145                 150                 155                 160 
Asn Tyr Lys Ala Phe Ser Gln Phe Met Arg Pro Leu Ile Ala Lys Lys
                165                 170                 175     
Asn Pro Lys Ile Pro Met Ser Lys Met Met Thr Ile Leu Gly Ala Lys
            180                 185                 190         
Trp Arg Glu Phe Ser Ala Asn Asn Pro Phe Lys Gly Ser Ala Ala Ala
        195                 200                 205             
Val Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Ala Glu Gln Val
    210                 215                 220                 
Ser Ala Ala Val Ser Ser Ala Thr Pro Ile Ala Pro Ser Gly Pro Pro
225                 230                 235                 240 
Ala Leu Pro Pro Pro Pro Ala Ala Asp Ile Gln Pro Pro Pro Ile Arg
                245                 250                 255     
Arg Ala Lys Thr Lys Glu Gly Lys Gly Pro Gly His Lys Arg Arg Ser
            260                 265                 270         
Lys Ser Pro Arg Val Pro Asp Gly Arg Lys Lys Leu Arg Gly Lys Lys
        275                 280                 285             
Met Ala Pro Leu Lys Ile Lys Leu Gly Leu Leu Gly Gly Lys Arg Lys
    290                 295                 300                 
Lys Gly Gly Ser Tyr Val Phe Gln Ser Asp Glu Gly Pro Glu Pro Glu
305                 310                 315                 320 
Ala Glu Glu Ser Asp Leu Asp Ser Gly Ser Val His Ser Ala Ser Gly
                325                 330                 335     
Arg Pro Asp Gly Pro Val Arg Thr Lys Lys Leu Lys Arg Gly Arg Pro
            340                 345                 350         
Gly Arg Lys Lys Lys Lys Val Leu Gly Cys Pro Ala Val Ala Gly Glu
        355                 360                 365             
Glu Glu Val Asp Gly Tyr Glu Thr Asp His Gln Asp Tyr Cys Glu Val
    370                 375                 380                 
Cys Gln Gln Gly Gly Glu Ile Ile Leu Cys Asp Thr Cys Pro Arg Ala
385                 390                 395                 400 
Tyr His Leu Val Cys Leu Asp Pro Glu Leu Asp Arg Ala Pro Glu Gly
                405                 410                 415     
Lys Trp Ser Cys Pro His Cys Glu Lys Glu Gly Val Gln Trp Glu Ala
            420                 425                 430         
Lys Glu Glu Glu Glu Glu Tyr Glu Glu Glu Gly Glu Glu Glu Gly Glu
        435                 440                 445             
Lys Glu Glu Glu Asp Asp His Met Glu Tyr Cys Arg Val Cys Lys Asp
    450                 455                 460                 
Gly Gly Glu Leu Leu Cys Cys Asp Ala Cys Ile Ser Ser Tyr His Ile
465                 470                 475                 480 
His Cys Leu Asn Pro Pro Leu Pro Asp Ile Pro Asn Gly Glu Trp Leu
                485                 490                 495     
Cys Pro Arg Cys Thr Cys Pro Val Leu Lys Gly Arg Val Gln Lys Ile
            500                 505                 510         
Leu His Trp Arg Trp Gly Glu Pro Pro Val Ala Val Pro Ala Pro Gln
        515                 520                 525             
Gln Ala Asp Gly Asn Pro Asp Val Pro Pro Pro Arg Pro Leu Gln Gly
    530                 535                 540                 
Arg Ser Glu Arg Glu Phe Phe Val Lys Trp Val Gly Leu Ser Tyr Trp
545                 550                 555                 560 
His Cys Ser Trp Ala Lys Glu Leu Gln Leu Glu Ile Phe His Leu Val
                565                 570                 575     
Met Tyr Arg Asn Tyr Gln Arg Lys Asn Asp Met Asp Glu Pro Pro Pro
            580                 585                 590         
Leu Asp Tyr Gly Ser Gly Glu Asp Asp Gly Lys Ser Asp Lys Arg Lys
        595                 600                 605             
Val Lys Asp Pro His Tyr Ala Glu Met Glu Glu Lys Tyr Tyr Arg Phe
    610                 615                 620                 
Gly Ile Lys Pro Glu Trp Met Thr Val His Arg Ile Ile Asn His Ser
625                 630                 635                 640 
Val Asp Lys Lys Gly Asn Tyr His Tyr Leu Val Lys Trp Arg Asp Leu
                645                 650                 655     
Pro Tyr Asp Gln Ser Thr Trp Glu Glu Asp Glu Met Asn Ile Pro Glu
            660                 665                 670         
Tyr Glu Glu His Lys Gln Ser Tyr Trp Arg His Arg Glu Leu Ile Met
        675                 680                 685             
Gly Glu Asp Pro Ala Gln Pro Arg Lys Tyr Lys Lys Lys Lys Lys Glu
    690                 695                 700                 
Leu Gln Gly Asp Gly Pro Pro Ser Ser Pro Thr Asn Asp Pro Thr Val
705                 710                 715                 720 
Lys Tyr Glu Thr Gln Pro Arg Phe Ile Thr Ala Thr Gly Gly Thr Leu
                725                 730                 735     
His Met Tyr Gln Leu Glu Gly Leu Asn Trp Leu Arg Phe Ser Trp Ala
            740                 745                 750         
Gln Gly Thr Asp Thr Ile Leu Ala Asp Glu Met Gly Leu Gly Lys Thr
        755                 760                 765             
Ile Gln Thr Ile Val Phe Leu Tyr Ser Leu Tyr Lys Glu Gly His Thr
    770                 775                 780                 
Lys Gly Pro Phe Leu Val Ser Ala Pro Leu Ser Thr Ile Ile Asn Trp
785                 790                 795                 800 
Glu Arg Glu Phe Gln Met Trp Ala Pro Lys Phe Tyr Val Val Thr Tyr
                805                 810                 815     
Thr Gly Asp Lys Asp Ser Arg Ala Ile Ile Arg Glu Asn Glu Phe Ser
            820                 825                 830         
Phe Glu Asp Asn Ala Ile Lys Gly Gly Lys Lys Ala Phe Lys Met Lys
        835                 840                 845             
Arg Glu Ala Gln Val Lys Phe His Val Leu Leu Thr Ser Tyr Glu Leu
    850                 855                 860                 
Ile Thr Ile Asp Gln Ala Ala Leu Gly Ser Ile Arg Trp Ala Cys Leu
865                 870                 875                 880 
Val Val Asp Glu Ala His Arg Leu Lys Asn Asn Gln Ser Lys Phe Phe
                885                 890                 895     
Arg Val Leu Asn Gly Tyr Lys Ile Asp His Lys Leu Leu Leu Thr Gly
            900                 905                 910         
Thr Pro Leu Gln Asn Asn Leu Glu Glu Leu Phe His Leu Leu Asn Phe
        915                 920                 925             
Leu Thr Pro Glu Arg Phe Asn Asn Leu Glu Gly Phe Leu Glu Glu Phe
    930                 935                 940                 
Ala Asp Ile Ser Lys Glu Asp Gln Ile Lys Lys Leu His Asp Leu Leu
945                 950                 955                 960 
Gly Pro His Met Leu Arg Arg Leu Lys Ala Asp Val Phe Lys Asn Met
                965                 970                 975     
Pro Ala Lys Thr Glu Leu Ile Val Arg Val Glu Leu Ser Pro Met Gln
            980                 985                 990         
Lys Lys Tyr Tyr Lys Tyr Ile Leu Thr Arg Asn Phe Glu Ala Leu Asn
        995                 1000                1005            
Ser Arg Gly Gly Gly Asn Gln Val Ser Leu Leu Asn Ile Met Met Asp
    1010                1015                1020                
Leu Lys Lys Cys Cys Asn His Pro Tyr Leu Phe Pro Val Ala Ala Met
1025                1030                1035                1040
Glu Ser Pro Lys Leu Pro Ser Gly Ala Tyr Glu Gly Gly Ala Leu Ile
                1045                1050                1055    
Lys Ser Ser Gly Lys Leu Met Leu Leu Gln Lys Met Leu Arg Lys Leu
            1060                1065                1070        
Lys Glu Gln Gly His Arg Val Leu Ile Phe Ser Gln Met Thr Lys Met
        1075                1080                1085            
Leu Asp Leu Leu Glu Asp Phe Leu Asp Tyr Glu Gly Tyr Lys Tyr Glu
    1090                1095                1100                
Arg Ile Asp Gly Gly Ile Thr Gly Ala Leu Arg Gln Glu Ala Ile Asp
1105                1110                1115                1120
Arg Phe Asn Ala Pro Gly Ala Gln Gln Phe Cys Phe Leu Leu Ser Thr
                1125                1130                1135    
Arg Ala Gly Gly Leu Gly Ile Asn Leu Ala Thr Ala Asp Thr Val Ile
            1140                1145                1150        
Ile Phe Asp Ser Asp Trp Asn Pro His Asn Asp Ile Gln Ala Phe Ser
        1155                1160                1165            
Arg Ala His Arg Ile Gly Gln Ala Asn Lys Val Met Ile Tyr Arg Phe
    1170                1175                1180                
Val Thr Arg Ala Ser Val Glu Glu Arg Ile Thr Gln Val Ala Lys Arg
1185                1190                1195                1200
Lys Met Met Leu Thr His Leu Val Val Arg Pro Gly Leu Gly Ser Lys
                1205                1210                1215    
Ala Gly Ser Met Ser Lys Gln Glu Leu Asp Asp Ile Leu Lys Phe Gly
            1220                1225                1230        
Thr Glu Glu Leu Phe Lys Asp Glu Asn Glu Gly Glu Asn Lys Glu Glu
        1235                1240                1245            
Asp Ser Ser Val Ile His Tyr Asp Asn Glu Ala Ile Ala Arg Leu Leu
    1250                1255                1260                
Asp Arg Asn Gln Asp Ala Thr Glu Asp Thr Asp Val Gln Asn Met Asn
1265                1270                1275                1280
Glu Tyr Leu Ser Ser Phe Lys Val Ala Gln Tyr Val Val Arg Glu Glu
                1285                1290                1295    
Asp Lys Ile Glu Glu Ile Glu Arg Glu Ile Ile Lys Gln Glu Glu Asn
            1300                1305                1310        
Val Asp Pro Asp Tyr Trp Glu Lys Leu Leu Arg His His Tyr Glu Gln
        1315                1320                1325            
Gln Gln Glu Asp Leu Ala Arg Asn Leu Gly Lys Gly Lys Arg Val Arg
    1330                1335                1340                
Lys Gln Val Asn Tyr Asn Asp Ala Ala Gln Glu Asp Gln Asp Asn Gln
1345                1350                1355                1360
Ser Glu Tyr Ser Val Gly Ser Glu Glu Glu Asp Glu Asp Phe Asp Glu
                1365                1370                1375    
Arg Pro Glu Gly Arg Arg Gln Ser Lys Arg Gln Leu Arg Asn Glu Lys
            1380                1385                1390        
Asp Lys Pro Leu Pro Pro Leu Leu Ala Arg Val Gly Gly Asn Ile Glu
        1395                1400                1405            
Val Leu Gly Phe Asn Thr Arg Gln Arg Lys Ala Phe Leu Asn Ala Val
    1410                1415                1420                
Met Arg Trp Gly Met Pro Pro Gln Asp Ala Phe Thr Thr Gln Trp Leu
1425                1430                1435                1440
Val Arg Asp Leu Arg Gly Lys Thr Glu Lys Glu Phe Lys Ala Tyr Val
                1445                1450                1455    
Ser Leu Phe Met Arg His Leu Cys Glu Pro Gly Ala Asp Gly Ser Glu
            1460                1465                1470        
Thr Phe Ala Asp Gly Val Pro Arg Glu Gly Leu Ser Arg Gln Gln Val
        1475                1480                1485            
Leu Thr Arg Ile Gly Val Met Ser Leu Val Lys Lys Lys Val Gln Glu
    1490                1495                1500                
Phe Glu His Ile Asn Gly Arg Trp Ser Met Pro Glu Leu Met Pro Asp
1505                1510                1515                1520
Pro Ser Ala Asp Ser Lys Arg Ser Ser Arg Ala Ser Ser Pro Thr Lys
                1525                1530                1535    
Thr Ser Pro Thr Thr Pro Glu Ala Ser Ala Thr Asn Ser Pro Cys Thr
            1540                1545                1550        
Ser Lys Pro Ala Thr Pro Ala Pro Ser Glu Lys Gly Glu Gly Ile Arg
        1555                1560                1565            
Thr Pro Leu Glu Lys Glu Glu Ala Glu Asn Gln Glu Glu Lys Pro Glu
    1570                1575                1580                
Lys Asn Ser Arg Ile Gly Glu Lys Met Glu Thr Glu Ala Asp Ala Pro
1585                1590                1595                1600
Ser Pro Ala Pro Ser Leu Gly Glu Arg Leu Glu Pro Arg Lys Ile Pro
                1605                1610                1615    
Leu Glu Asp Glu Val Pro Gly Val Pro Gly Glu Met Glu Pro Glu Pro
            1620                1625                1630        
Gly Tyr Arg Gly Asp Arg Glu Lys Ser Glu Asp Val Lys Gly Asp Arg
        1635                1640                1645            
Glu Leu Arg Pro Gly Pro Arg Asp Glu Pro Arg Ser Asn Gly Arg Arg
    1650                1655                1660                
Glu Glu Lys Thr Glu Lys Pro Arg Phe Met Phe Asn Ile Ala Asp Gly
1665                1670                1675                1680
Gly Phe Thr Glu Leu His Thr Leu Trp Gln Asn Glu Glu Arg Ala Ala
                1685                1690                1695    
Ile Ser Ser Gly Lys Leu Asn Glu Ile Trp His Arg Arg His Asp Tyr
            1700                1705                1710        
Trp Leu Leu Ala Gly Ile Val Leu His Gly Tyr Ala Arg Trp Gln Asp
        1715                1720                1725            
Ile Gln Asn Asp Ala Gln Phe Ala Ile Ile Asn Glu Pro Phe Lys Thr
    1730                1735                1740                
Glu Ala Asn Lys Gly Asn Phe Leu Glu Met Lys Asn Lys Phe Leu Ala
1745                1750                1755                1760
Arg Arg Phe Lys Leu Leu Glu Gln Ala Leu Val Ile Glu Glu Gln Leu
                1765                1770                1775    
Arg Arg Ala Ala Tyr Leu Asn Leu Ser Gln Glu Pro Ala His Pro Ala
            1780                1785                1790        
Met Ala Leu His Ala Arg Phe Ala Glu Ala Glu Cys Leu Ala Glu Ser
        1795                1800                1805            
His Gln His Leu Ser Lys Glu Ser Leu Ala Gly Asn Lys Pro Ala Asn
    1810                1815                1820                
Ala Val Leu His Lys Val Leu Asn Gln Leu Glu Glu Leu Leu Ser Asp
1825                1830                1835                1840
Met Lys Ala Asp Val Thr Arg Leu Pro Ala Thr Leu Ser Arg Ile Pro
                1845                1850                1855    
Pro Ile Ala Ala Arg Leu Gln Met Ser Glu Arg Ser Ile Leu Ser Arg
            1860                1865                1870        
Leu Ala Ser Lys Gly Thr Glu Pro His Pro Thr Pro Ala Tyr Pro Pro
        1875                1880                1885            
Gly Pro Tyr Ala Thr Pro Pro Gly Tyr Gly Ala Ala Phe Ser Ala Ala
    1890                1895                1900                
Pro Val Gly Ala Leu Ala Ala Ala Gly Ala Asn Tyr Ser Gln Met Pro
1905                1910                1915                1920
Ala Gly Ser Phe Ile Thr Ala Ala Thr Asn Gly Pro Ile His Arg Phe
                1925                1930                1935    
Phe Lys Lys Val Pro Glu Ile Gln
            1940                


<210> 546
<211> 1493
<212> PRT
<213> Homo sapiens

<400> 546
Met Pro Asn Glu Gly Ile Pro His Ser Ser Gln Thr Gln Glu Gln Asp
 1               5                  10                  15      
Cys Leu Gln Ser Gln Pro Val Ser Asn Asn Glu Glu Met Ala Ile Lys
            20                  25                  30          
Gln Glu Ser Gly Gly Asp Gly Glu Val Glu Glu Tyr Leu Ser Phe Arg
        35                  40                  45              
Ser Val Gly Asp Gly Leu Ser Thr Ser Ala Val Gly Cys Ala Ser Ala
    50                  55                  60                  
Ala Pro Arg Arg Gly Pro Ala Leu Leu His Ile Asp Arg His Gln Ile
65                  70                  75                  80  
Gln Ala Val Glu Pro Ser Ala Gln Ala Leu Glu Leu Gln Gly Leu Gly
                85                  90                  95      
Val Asp Val Tyr Asp Gln Asp Val Leu Glu Gln Gly Val Leu Gln Gln
            100                 105                 110         
Val Asp Asn Ala Ile His Glu Ala Ser Arg Ala Ser Gln Leu Val Asp
        115                 120                 125             
Val Glu Lys Glu Tyr Arg Ser Val Leu Asp Asp Leu Thr Ser Cys Thr
    130                 135                 140                 
Thr Ser Leu Arg Gln Ile Asn Lys Ile Ile Glu Gln Leu Ser Pro Gln
145                 150                 155                 160 
Ala Ala Thr Ser Arg Asp Ile Asn Arg Lys Leu Asp Ser Val Lys Arg
                165                 170                 175     
Gln Lys Tyr Asn Lys Glu Gln Gln Leu Lys Lys Ile Thr Ala Lys Gln
            180                 185                 190         
Lys His Leu Gln Ala Ile Leu Gly Gly Ala Glu Val Lys Ile Glu Leu
        195                 200                 205             
Asp His Ala Ser Leu Glu Glu Asp Ala Glu Pro Gly Pro Ser Ser Leu
    210                 215                 220                 
Gly Ser Met Leu Met Pro Val Gln Glu Thr Ala Trp Glu Glu Leu Ile
225                 230                 235                 240 
Arg Thr Gly Gln Met Thr Pro Phe Gly Thr Gln Ile Pro Gln Lys Gln
                245                 250                 255     
Glu Lys Lys Pro Arg Lys Ile Met Leu Asn Glu Ala Ser Gly Phe Glu
            260                 265                 270         
Lys Tyr Leu Ala Asp Gln Ala Lys Leu Ser Phe Glu Arg Lys Lys Gln
        275                 280                 285             
Gly Cys Asn Lys Arg Ala Ala Arg Lys Ala Pro Ala Pro Val Thr Pro
    290                 295                 300                 
Pro Ala Pro Val Gln Asn Lys Asn Lys Pro Asn Lys Lys Ala Arg Val
305                 310                 315                 320 
Leu Ser Lys Lys Glu Glu Arg Leu Lys Lys His Ile Lys Lys Leu Gln
                325                 330                 335     
Lys Arg Ala Leu Gln Phe Gln Gly Lys Val Gly Leu Pro Lys Ala Arg
            340                 345                 350         
Arg Pro Trp Glu Ser Asp Met Arg Pro Glu Ala Glu Gly Asp Ser Glu
        355                 360                 365             
Gly Glu Glu Ser Glu Tyr Phe Pro Thr Glu Glu Glu Glu Glu Glu Glu
    370                 375                 380                 
Asp Asp Glu Val Glu Gly Ala Glu Ala Asp Leu Ser Gly Asp Gly Thr
385                 390                 395                 400 
Asp Tyr Glu Leu Lys Pro Leu Pro Lys Gly Gly Lys Arg Gln Lys Lys
                405                 410                 415     
Val Pro Val Gln Glu Ile Asp Asp Asp Phe Phe Pro Ser Ser Gly Glu
            420                 425                 430         
Glu Ala Glu Ala Ala Ser Val Gly Glu Gly Gly Gly Gly Gly Arg Lys
        435                 440                 445             
Val Gly Arg Tyr Arg Asp Asp Gly Asp Glu Asp Tyr Tyr Lys Gln Arg
    450                 455                 460                 
Leu Arg Arg Trp Asn Lys Leu Arg Leu Gln Asp Lys Glu Lys Arg Leu
465                 470                 475                 480 
Lys Leu Glu Asp Asp Ser Glu Glu Ser Asp Ala Glu Phe Asp Glu Gly
                485                 490                 495     
Phe Lys Val Pro Gly Phe Leu Phe Lys Lys Leu Phe Lys Tyr Gln Gln
            500                 505                 510         
Thr Gly Val Arg Trp Leu Trp Glu Leu His Cys Gln Gln Ala Gly Gly
        515                 520                 525             
Ile Leu Gly Asp Glu Met Gly Leu Gly Lys Thr Ile Gln Ile Ile Ala
    530                 535                 540                 
Phe Leu Ala Gly Leu Ser Tyr Ser Lys Ile Arg Thr Arg Gly Ser Asn
545                 550                 555                 560 
Tyr Arg Phe Glu Gly Leu Gly Pro Thr Val Ile Val Cys Pro Thr Thr
                565                 570                 575     
Val Met His Gln Trp Val Lys Glu Phe His Thr Trp Trp Pro Pro Phe
            580                 585                 590         
Arg Val Ala Ile Leu His Glu Thr Gly Ser Tyr Thr His Lys Lys Glu
        595                 600                 605             
Lys Leu Ile Arg Asp Val Ala His Cys His Gly Ile Leu Ile Thr Ser
    610                 615                 620                 
Tyr Ser Tyr Ile Arg Leu Met Gln Asp Asp Ile Ser Arg Tyr Asp Trp
625                 630                 635                 640 
His Tyr Val Ile Leu Asp Glu Gly His Lys Ile Arg Asn Pro Asn Ala
                645                 650                 655     
Ala Val Thr Leu Ala Cys Lys Gln Phe Arg Thr Pro His Arg Ile Ile
            660                 665                 670         
Leu Ser Gly Ser Pro Met Gln Asn Asn Leu Arg Glu Leu Trp Ser Leu
        675                 680                 685             
Phe Asp Phe Ile Phe Pro Gly Lys Leu Gly Thr Leu Pro Val Phe Met
    690                 695                 700                 
Glu Gln Phe Ser Val Pro Ile Thr Met Gly Gly Tyr Ser Asn Ala Ser
705                 710                 715                 720 
Pro Val Gln Val Lys Thr Ala Tyr Lys Cys Ala Cys Val Leu Arg Asp
                725                 730                 735     
Thr Ile Asn Pro Tyr Leu Leu Arg Arg Met Lys Ser Asp Val Lys Met
            740                 745                 750         
Ser Leu Ser Leu Pro Asp Lys Asn Glu Gln Val Leu Phe Cys Arg Leu
        755                 760                 765             
Thr Asp Glu Gln His Lys Val Tyr Gln Asn Phe Val Asp Ser Lys Glu
    770                 775                 780                 
Val Tyr Arg Ile Leu Asn Gly Glu Met Gln Ile Phe Ser Gly Leu Ile
785                 790                 795                 800 
Ala Leu Arg Lys Ile Cys Asn His Pro Asp Leu Phe Ser Gly Gly Pro
                805                 810                 815     
Lys Asn Leu Lys Gly Leu Pro Asp Asp Glu Leu Glu Glu Asp Gln Phe
            820                 825                 830         
Gly Tyr Trp Lys Arg Ser Gly Lys Met Ile Val Val Glu Ser Leu Leu
        835                 840                 845             
Lys Ile Trp His Lys Gln Gly Gln Arg Val Leu Leu Phe Ser Gln Ser
    850                 855                 860                 
Arg Gln Met Leu Asp Ile Leu Glu Val Phe Leu Arg Ala Gln Lys Tyr
865                 870                 875                 880 
Thr Tyr Leu Lys Met Asp Gly Thr Thr Thr Ile Ala Ser Arg Gln Pro
                885                 890                 895     
Leu Ile Thr Arg Tyr Asn Glu Asp Thr Ser Ile Phe Val Phe Leu Leu
            900                 905                 910         
Thr Thr Arg Val Gly Gly Leu Gly Val Asn Leu Thr Gly Ala Asn Arg
        915                 920                 925             
Val Val Ile Tyr Asp Pro Asp Trp Asn Pro Ser Thr Asp Thr Gln Ala
    930                 935                 940                 
Arg Glu Arg Ala Trp Arg Ile Gly Gln Lys Lys Gln Val Thr Val Tyr
945                 950                 955                 960 
Arg Leu Leu Thr Ala Gly Thr Ile Glu Glu Lys Ile Tyr His Arg Gln
                965                 970                 975     
Ile Phe Lys Gln Phe Leu Thr Asn Arg Val Leu Lys Asp Pro Lys Gln
            980                 985                 990         
Arg Arg Phe Phe Lys Ser Asn Asp Leu Tyr Glu Leu Phe Thr Leu Thr
        995                 1000                1005            
Ser Pro Asp Ala Ser Gln Ser Thr Glu Thr Ser Ala Ile Phe Ala Gly
    1010                1015                1020                
Thr Gly Ser Asp Val Gln Thr Pro Lys Cys His Leu Lys Arg Arg Ile
1025                1030                1035                1040
Gln Pro Ala Phe Gly Ala Asp His Asp Val Pro Lys Arg Lys Lys Phe
                1045                1050                1055    
Pro Ala Ser Asn Ile Ser Val Asn Asp Ala Thr Ser Ser Glu Glu Lys
            1060                1065                1070        
Ser Glu Ala Lys Gly Ala Glu Val Asn Ala Val Thr Ser Asn Arg Ser
        1075                1080                1085            
Asp Pro Leu Lys Asp Asp Pro His Met Ser Ser Asn Val Thr Ser Asn
    1090                1095                1100                
Asp Arg Leu Gly Glu Glu Thr Asn Ala Val Ser Gly Pro Glu Glu Leu
1105                1110                1115                1120
Ser Val Ile Ser Gly Asn Gly Glu Cys Ser Asn Ser Ser Gly Thr Gly
                1125                1130                1135    
Lys Thr Ser Met Pro Ser Gly Asp Glu Ser Ile Asp Glu Lys Leu Gly
            1140                1145                1150        
Leu Ser Tyr Lys Arg Glu Arg Pro Ser Gln Ala Gln Thr Glu Ala Phe
        1155                1160                1165            
Trp Glu Asn Lys Gln Met Glu Asn Asn Phe Tyr Lys His Lys Ser Lys
    1170                1175                1180                
Thr Lys His His Ser Val Ala Glu Glu Glu Thr Leu Glu Lys His Leu
1185                1190                1195                1200
Arg Pro Lys Gln Lys Pro Lys Asn Ser Lys His Cys Arg Asp Ala Lys
                1205                1210                1215    
Phe Glu Gly Thr Arg Ile Pro His Leu Val Lys Lys Arg Arg Tyr Gln
            1220                1225                1230        
Lys Gln Asp Ser Glu Asn Lys Ser Glu Ala Lys Glu Gln Ser Asn Asp
        1235                1240                1245            
Asp Tyr Val Leu Glu Lys Leu Phe Lys Lys Ser Val Gly Val His Ser
    1250                1255                1260                
Val Met Lys His Asp Ala Ile Met Asp Gly Ala Ser Pro Asp Tyr Val
1265                1270                1275                1280
Leu Val Glu Ala Glu Ala Asn Arg Val Ala Gln Asp Ala Leu Lys Ala
                1285                1290                1295    
Leu Arg Leu Ser Arg Gln Arg Cys Leu Gly Ala Val Ser Gly Val Pro
            1300                1305                1310        
Thr Trp Thr Gly His Arg Gly Ile Ser Gly Ala Pro Ala Gly Lys Lys
        1315                1320                1325            
Ser Arg Phe Gly Lys Lys Arg Asn Ser Asn Phe Ser Val Gln His Pro
    1330                1335                1340                
Ser Ser Thr Ser Pro Thr Glu Lys Cys Gln Asp Gly Ile Met Lys Lys
1345                1350                1355                1360
Glu Gly Lys Asp Asn Val Pro Glu His Phe Ser Gly Arg Ala Glu Asp
                1365                1370                1375    
Ala Asp Ser Ser Ser Gly Pro Leu Ala Ser Ser Ser Leu Leu Ala Lys
            1380                1385                1390        
Met Arg Ala Arg Asn His Leu Ile Leu Pro Glu Arg Leu Glu Ser Glu
        1395                1400                1405            
Ser Gly His Leu Gln Glu Ala Ser Ala Leu Leu Pro Thr Thr Glu His
    1410                1415                1420                
Asp Asp Leu Leu Val Glu Met Arg Asn Phe Ile Ala Phe Gln Ala His
1425                1430                1435                1440
Thr Asp Gly Gln Ala Ser Thr Arg Glu Ile Leu Gln Glu Phe Glu Ser
                1445                1450                1455    
Lys Leu Ser Ala Ser Gln Ser Cys Val Phe Arg Glu Leu Leu Arg Asn
            1460                1465                1470        
Leu Cys Thr Phe His Arg Thr Ser Gly Gly Glu Gly Ile Trp Lys Leu
        1475                1480                1485            
Lys Pro Glu Tyr Cys
    1490            


<210> 547
<211> 132
<212> PRT
<213> Homo sapiens

<400> 547
Met Cys Asp Ala Phe Val Gly Thr Trp Lys Leu Val Ser Ser Glu Asn
 1               5                  10                  15      
Phe Asp Asp Tyr Met Lys Glu Val Gly Val Gly Phe Ala Thr Arg Lys
            20                  25                  30          
Val Ala Gly Met Ala Lys Pro Asn Met Ile Ile Ser Val Asn Gly Asp
        35                  40                  45              
Val Ile Thr Ile Lys Ser Glu Ser Thr Phe Lys Asn Thr Glu Ile Ser
    50                  55                  60                  
Phe Ile Leu Gly Gln Glu Phe Asp Glu Val Thr Ala Asp Asp Arg Lys
65                  70                  75                  80  
Val Lys Ser Thr Ile Thr Leu Asp Gly Gly Val Leu Val His Val Gln
                85                  90                  95      
Lys Trp Asp Gly Lys Ser Thr Thr Ile Lys Arg Lys Arg Glu Asp Asp
            100                 105                 110         
Lys Leu Val Val Glu Cys Val Met Lys Gly Val Thr Ser Thr Arg Val
        115                 120                 125             
Tyr Glu Arg Ala
    130         


<210> 548
<211> 206
<212> PRT
<213> Homo sapiens

<400> 548
Met Ala Ala Thr Arg Cys Leu Arg Trp Gly Leu Ser Arg Ala Gly Val
 1               5                  10                  15      
Trp Leu Leu Pro Pro Pro Ala Arg Cys Pro Arg Arg Ala Leu His Lys
            20                  25                  30          
Gln Lys Asp Gly Thr Glu Phe Lys Ser Ile Tyr Ser Leu Asp Lys Leu
        35                  40                  45              
Tyr Pro Glu Ser Gln Gly Ser Asp Thr Ala Trp Arg Val Pro Asn Gly
    50                  55                  60                  
Ala Lys Gln Ala Asp Ser Asp Ile Pro Leu Asp Arg Leu Thr Ile Ser
65                  70                  75                  80  
Tyr Cys Arg Ser Ser Gly Pro Gly Gly Gln Asn Val Asn Lys Val Asn
                85                  90                  95      
Ser Lys Ala Glu Val Arg Phe His Leu Ala Thr Ala Glu Trp Ile Ala
            100                 105                 110         
Glu Pro Val Arg Gln Lys Ile Ala Ile Thr His Lys Asn Lys Ile Asn
        115                 120                 125             
Arg Leu Gly Glu Leu Ile Leu Thr Ser Glu Ser Ser Arg Tyr Gln Phe
    130                 135                 140                 
Arg Asn Leu Ala Asp Cys Leu Gln Lys Ile Arg Asp Met Ile Thr Glu
145                 150                 155                 160 
Ala Ser Gln Thr Pro Lys Glu Pro Thr Lys Glu Asp Val Lys Leu His
                165                 170                 175     
Arg Ile Arg Ile Glu Asn Met Asn Arg Glu Arg Leu Arg Gln Lys Arg
            180                 185                 190         
Ile His Ser Ala Val Lys Thr Ser Arg Arg Val Asp Met Asp
        195                 200                 205     


<210> 549
<211> 527
<212> PRT
<213> Homo sapiens

<400> 549
Met Glu Asn Gln Glu Lys Ala Ser Ile Ala Gly His Met Phe Asp Val
 1               5                  10                  15      
Val Val Ile Gly Gly Gly Ile Ser Gly Leu Ser Ala Ala Lys Leu Leu
            20                  25                  30          
Thr Glu Tyr Gly Val Ser Val Leu Val Leu Glu Ala Arg Asp Arg Val
        35                  40                  45              
Gly Gly Arg Thr Tyr Thr Ile Arg Asn Glu His Val Asp Tyr Val Asp
    50                  55                  60                  
Val Gly Gly Ala Tyr Val Gly Pro Thr Gln Asn Arg Ile Leu Arg Leu
65                  70                  75                  80  
Ser Lys Glu Leu Gly Ile Glu Thr Tyr Lys Val Asn Val Ser Glu Arg
                85                  90                  95      
Leu Val Gln Tyr Val Lys Gly Lys Thr Tyr Pro Phe Arg Gly Ala Phe
            100                 105                 110         
Pro Pro Val Trp Asn Pro Ile Ala Tyr Leu Asp Tyr Asn Asn Leu Trp
        115                 120                 125             
Arg Thr Ile Asp Asn Met Gly Lys Glu Ile Pro Thr Asp Ala Pro Trp
    130                 135                 140                 
Glu Ala Gln His Ala Asp Lys Trp Asp Lys Met Thr Met Lys Glu Leu
145                 150                 155                 160 
Ile Asp Lys Ile Cys Trp Thr Lys Thr Ala Arg Arg Phe Ala Tyr Leu
                165                 170                 175     
Phe Val Asn Ile Asn Val Thr Ser Glu Pro His Glu Val Ser Ala Leu
            180                 185                 190         
Trp Phe Leu Trp Tyr Val Lys Gln Cys Gly Gly Thr Thr Arg Ile Phe
        195                 200                 205             
Ser Val Thr Asn Gly Gly Gln Glu Arg Lys Phe Val Gly Gly Ser Gly
    210                 215                 220                 
Gln Val Ser Glu Arg Ile Met Asp Leu Leu Gly Asp Gln Val Lys Leu
225                 230                 235                 240 
Asn His Pro Val Thr His Val Asp Gln Ser Ser Asp Asn Ile Ile Ile
                245                 250                 255     
Glu Thr Leu Asn His Glu His Tyr Glu Cys Lys Tyr Val Ile Asn Ala
            260                 265                 270         
Ile Pro Pro Thr Leu Thr Ala Lys Ile His Phe Arg Pro Glu Leu Pro
        275                 280                 285             
Ala Glu Arg Asn Gln Leu Ile Gln Arg Leu Pro Met Gly Ala Val Ile
    290                 295                 300                 
Lys Cys Met Met Tyr Tyr Lys Glu Ala Phe Trp Lys Lys Lys Asp Tyr
305                 310                 315                 320 
Cys Gly Cys Met Ile Ile Glu Asp Glu Asp Ala Pro Ile Ser Ile Thr
                325                 330                 335     
Leu Asp Asp Thr Lys Pro Asp Gly Ser Leu Pro Ala Ile Met Gly Phe
            340                 345                 350         
Ile Leu Ala Arg Lys Ala Asp Arg Leu Ala Lys Leu His Lys Glu Ile
        355                 360                 365             
Arg Lys Lys Lys Ile Cys Glu Leu Tyr Ala Lys Val Leu Gly Ser Gln
    370                 375                 380                 
Glu Ala Leu His Pro Val His Tyr Glu Glu Lys Asn Trp Cys Glu Glu
385                 390                 395                 400 
Gln Tyr Ser Gly Gly Cys Tyr Thr Ala Tyr Phe Pro Pro Gly Ile Met
                405                 410                 415     
Thr Gln Tyr Gly Arg Val Ile Arg Gln Pro Val Gly Arg Ile Phe Phe
            420                 425                 430         
Ala Gly Thr Glu Thr Ala Thr Lys Trp Ser Gly Tyr Met Glu Gly Ala
        435                 440                 445             
Val Glu Ala Gly Glu Arg Ala Ala Arg Glu Val Leu Asn Gly Leu Gly
    450                 455                 460                 
Lys Val Thr Glu Lys Asp Ile Trp Val Gln Glu Pro Glu Ser Lys Asp
465                 470                 475                 480 
Val Pro Ala Val Glu Ile Thr His Thr Phe Trp Glu Arg Asn Leu Pro
                485                 490                 495     
Ser Val Ser Gly Leu Leu Lys Ile Ile Gly Phe Ser Thr Ser Val Thr
            500                 505                 510         
Ala Leu Gly Phe Val Leu Tyr Lys Tyr Lys Leu Leu Pro Arg Ser
        515                 520                 525         


<210> 550
<211> 745
<212> PRT
<213> Homo sapiens

<400> 550
Met Gly Val Pro Phe Phe Ser Ser Leu Arg Cys Met Val Asp Leu Gly
 1               5                  10                  15      
Pro Cys Trp Ala Gly Gly Leu Thr Ala Glu Met Lys Leu Leu Leu Ala
            20                  25                  30          
Leu Ala Gly Leu Leu Ala Ile Leu Ala Thr Pro Gln Pro Ser Glu Gly
        35                  40                  45              
Ala Ala Pro Ala Val Leu Gly Glu Val Asp Thr Ser Leu Val Leu Ser
    50                  55                  60                  
Ser Met Glu Glu Ala Lys Gln Leu Val Asp Lys Ala Tyr Lys Glu Arg
65                  70                  75                  80  
Arg Glu Ser Ile Lys Gln Arg Leu Arg Ser Gly Ser Ala Ser Pro Met
                85                  90                  95      
Glu Leu Leu Ser Tyr Phe Lys Gln Pro Val Ala Ala Thr Arg Thr Ala
            100                 105                 110         
Val Arg Ala Ala Asp Tyr Leu His Val Ala Leu Asp Leu Leu Glu Arg
        115                 120                 125             
Lys Leu Arg Ser Leu Trp Arg Arg Pro Phe Asn Val Thr Asp Val Leu
    130                 135                 140                 
Thr Pro Ala Gln Leu Asn Val Leu Ser Lys Ser Ser Gly Cys Ala Tyr
145                 150                 155                 160 
Gln Asp Val Gly Val Thr Cys Pro Glu Gln Asp Lys Tyr Arg Thr Ile
                165                 170                 175     
Thr Gly Met Cys Asn Asn Arg Arg Ser Pro Thr Leu Gly Ala Ser Asn
            180                 185                 190         
Arg Ala Phe Val Arg Trp Leu Pro Ala Glu Tyr Glu Asp Gly Phe Ser
        195                 200                 205             
Leu Pro Tyr Gly Trp Thr Pro Gly Val Lys Arg Asn Gly Phe Pro Val
    210                 215                 220                 
Ala Leu Ala Arg Ala Val Ser Asn Glu Ile Val Arg Phe Pro Thr Asp
225                 230                 235                 240 
Gln Leu Thr Pro Asp Gln Glu Arg Ser Leu Met Phe Met Gln Trp Gly
                245                 250                 255     
Gln Leu Leu Asp His Asp Leu Asp Phe Thr Pro Glu Pro Ala Ala Arg
            260                 265                 270         
Ala Ser Phe Val Thr Gly Val Asn Cys Glu Thr Ser Cys Val Gln Gln
        275                 280                 285             
Pro Pro Cys Phe Pro Leu Lys Ile Pro Pro Asn Asp Pro Arg Ile Lys
    290                 295                 300                 
Asn Gln Ala Asp Cys Ile Pro Phe Phe Arg Ser Cys Pro Ala Cys Pro
305                 310                 315                 320 
Gly Ser Asn Ile Thr Ile Arg Asn Gln Ile Asn Ala Leu Thr Ser Phe
                325                 330                 335     
Val Asp Ala Ser Met Val Tyr Gly Ser Glu Glu Pro Leu Ala Arg Asn
            340                 345                 350         
Leu Arg Asn Met Ser Asn Gln Leu Gly Leu Leu Ala Val Asn Gln Arg
        355                 360                 365             
Phe Gln Asp Asn Gly Arg Ala Leu Leu Pro Phe Asp Asn Leu His Asp
    370                 375                 380                 
Asp Pro Cys Leu Leu Thr Asn Arg Ser Ala Arg Ile Pro Cys Phe Leu
385                 390                 395                 400 
Ala Gly Asp Thr Arg Ser Ser Glu Met Pro Glu Leu Thr Ser Met His
                405                 410                 415     
Thr Leu Leu Leu Arg Glu His Asn Arg Leu Ala Thr Glu Leu Lys Ser
            420                 425                 430         
Leu Asn Pro Arg Trp Asp Gly Glu Arg Leu Tyr Gln Glu Ala Arg Lys
        435                 440                 445             
Ile Val Gly Ala Met Val Gln Ile Ile Thr Tyr Arg Asp Tyr Leu Pro
    450                 455                 460                 
Leu Val Leu Gly Pro Thr Ala Met Arg Lys Tyr Leu Pro Thr Tyr Arg
465                 470                 475                 480 
Ser Tyr Asn Asp Ser Val Asp Pro Arg Ile Ala Asn Val Phe Thr Asn
                485                 490                 495     
Ala Phe Arg Tyr Gly His Thr Leu Ile Gln Pro Phe Met Phe Arg Leu
            500                 505                 510         
Asp Asn Arg Tyr Gln Pro Met Glu Pro Asn Pro Arg Val Pro Leu Ser
        515                 520                 525             
Arg Val Phe Phe Ala Ser Trp Arg Val Val Leu Glu Gly Gly Ile Asp
    530                 535                 540                 
Pro Ile Leu Arg Gly Leu Met Ala Thr Pro Ala Lys Leu Asn Arg Gln
545                 550                 555                 560 
Asn Gln Ile Ala Val Asp Glu Ile Arg Glu Arg Leu Phe Glu Gln Val
                565                 570                 575     
Met Arg Ile Gly Leu Asp Leu Pro Ala Leu Asn Met Gln Arg Ser Arg
            580                 585                 590         
Asp His Gly Leu Pro Gly Tyr Asn Ala Trp Arg Arg Phe Cys Gly Leu
        595                 600                 605             
Pro Gln Pro Glu Thr Val Gly Gln Leu Gly Thr Val Leu Arg Asn Leu
    610                 615                 620                 
Lys Leu Ala Arg Lys Leu Met Glu Gln Tyr Gly Thr Pro Asn Asn Ile
625                 630                 635                 640 
Asp Ile Trp Met Gly Gly Val Ser Glu Pro Leu Lys Arg Lys Gly Arg
                645                 650                 655     
Val Gly Pro Leu Leu Ala Cys Ile Ile Gly Thr Gln Phe Arg Lys Leu
            660                 665                 670         
Arg Asp Gly Asp Arg Phe Trp Trp Glu Asn Glu Gly Val Phe Ser Met
        675                 680                 685             
Gln Gln Arg Gln Ala Leu Ala Gln Ile Ser Leu Pro Arg Ile Ile Cys
    690                 695                 700                 
Asp Asn Thr Gly Ile Thr Thr Val Ser Lys Asn Asn Ile Phe Met Ser
705                 710                 715                 720 
Asn Ser Tyr Pro Arg Asp Phe Val Asn Cys Ser Thr Leu Pro Ala Leu
                725                 730                 735     
Asn Leu Ala Ser Trp Arg Glu Ala Ser
            740                 745 


<210> 551
<211> 1265
<212> PRT
<213> Homo sapiens

<400> 551
Met Ser Pro Ala Leu Gln Asp Leu Ser Gln Pro Glu Gly Leu Lys Lys
 1               5                  10                  15      
Thr Leu Arg Asp Glu Ile Asn Ala Ile Leu Gln Lys Arg Ile Met Val
            20                  25                  30          
Leu Asp Gly Gly Met Gly Thr Met Ile Gln Arg Glu Lys Leu Asn Glu
        35                  40                  45              
Glu His Phe Arg Gly Gln Glu Phe Lys Asp His Ala Arg Pro Leu Lys
    50                  55                  60                  
Gly Asn Asn Asp Ile Leu Ser Ile Thr Gln Pro Asp Val Ile Tyr Gln
65                  70                  75                  80  
Ile His Lys Glu Tyr Leu Leu Ala Gly Ala Asp Ile Ile Glu Thr Asn
                85                  90                  95      
Thr Phe Ser Ser Thr Ser Ile Ala Gln Ala Asp Tyr Gly Leu Glu His
            100                 105                 110         
Leu Ala Tyr Arg Met Asn Met Cys Ser Ala Gly Val Ala Arg Lys Ala
        115                 120                 125             
Ala Glu Glu Val Thr Leu Gln Thr Gly Ile Lys Arg Phe Val Ala Gly
    130                 135                 140                 
Ala Leu Gly Pro Thr Asn Lys Thr Leu Ser Val Ser Pro Ser Val Glu
145                 150                 155                 160 
Arg Pro Asp Tyr Arg Asn Ile Thr Phe Asp Glu Leu Val Glu Ala Tyr
                165                 170                 175     
Gln Glu Gln Ala Lys Gly Leu Leu Asp Gly Gly Val Asp Ile Leu Leu
            180                 185                 190         
Ile Glu Thr Ile Phe Asp Thr Ala Asn Ala Lys Ala Ala Leu Phe Ala
        195                 200                 205             
Leu Gln Asn Leu Phe Glu Glu Lys Tyr Ala Pro Arg Pro Ile Phe Ile
    210                 215                 220                 
Ser Gly Thr Ile Val Asp Lys Ser Gly Arg Thr Leu Ser Gly Gln Thr
225                 230                 235                 240 
Gly Glu Gly Phe Val Ile Ser Val Ser His Gly Glu Pro Leu Tyr Ile
                245                 250                 255     
Gly Leu Asn Cys Ala Leu Gly Ala Ala Glu Met Arg Pro Phe Ile Glu
            260                 265                 270         
Ile Ile Gly Lys Cys Thr Thr Ala Tyr Val Leu Cys Tyr Pro Asn Ala
        275                 280                 285             
Gly Leu Pro Asn Thr Phe Gly Asp Tyr Asp Glu Thr Pro Ser Met Met
    290                 295                 300                 
Ala Lys His Leu Lys Asp Phe Ala Met Asp Gly Leu Val Asn Ile Val
305                 310                 315                 320 
Gly Gly Cys Cys Gly Ser Thr Pro Asp His Ile Arg Glu Ile Ala Glu
                325                 330                 335     
Ala Val Lys Asn Cys Lys Pro Arg Val Pro Pro Ala Thr Ala Phe Glu
            340                 345                 350         
Gly His Met Leu Leu Ser Gly Leu Glu Pro Phe Arg Ile Gly Pro Tyr
        355                 360                 365             
Thr Asn Phe Val Asn Ile Gly Glu Arg Cys Asn Val Ala Gly Ser Arg
    370                 375                 380                 
Lys Phe Ala Lys Leu Ile Met Ala Gly Asn Tyr Glu Glu Ala Leu Cys
385                 390                 395                 400 
Val Ala Lys Val Gln Val Glu Met Gly Ala Gln Val Leu Asp Val Asn
                405                 410                 415     
Met Asp Asp Gly Met Leu Asp Gly Pro Ser Ala Met Thr Arg Phe Cys
            420                 425                 430         
Asn Leu Ile Ala Ser Glu Pro Asp Ile Ala Lys Val Pro Leu Cys Ile
        435                 440                 445             
Asp Ser Ser Asn Phe Ala Val Ile Glu Ala Gly Leu Lys Cys Cys Gln
    450                 455                 460                 
Gly Lys Cys Ile Val Asn Ser Ile Ser Leu Lys Glu Gly Glu Asp Asp
465                 470                 475                 480 
Phe Leu Glu Lys Ala Arg Lys Ile Lys Lys Tyr Gly Ala Ala Met Val
                485                 490                 495     
Val Met Ala Phe Asp Glu Glu Gly Gln Ala Thr Glu Thr Asp Thr Lys
            500                 505                 510         
Ile Arg Val Cys Thr Arg Ala Tyr His Leu Leu Val Lys Lys Leu Gly
        515                 520                 525             
Phe Asn Pro Asn Asp Ile Ile Phe Asp Pro Asn Ile Leu Thr Ile Gly
    530                 535                 540                 
Thr Gly Met Glu Glu His Asn Leu Tyr Ala Ile Asn Phe Ile His Ala
545                 550                 555                 560 
Thr Lys Val Ile Lys Glu Thr Leu Pro Gly Ala Arg Ile Ser Gly Gly
                565                 570                 575     
Leu Ser Asn Leu Ser Phe Ser Phe Arg Gly Met Glu Ala Ile Arg Glu
            580                 585                 590         
Ala Met His Gly Val Phe Leu Tyr His Ala Ile Lys Ser Gly Met Asp
        595                 600                 605             
Met Gly Ile Val Asn Ala Gly Asn Leu Pro Val Tyr Asp Asp Ile His
    610                 615                 620                 
Lys Glu Leu Leu Gln Leu Cys Glu Asp Leu Ile Trp Asn Lys Asp Pro
625                 630                 635                 640 
Glu Ala Thr Glu Lys Leu Leu Arg Tyr Ala Gln Thr Gln Gly Thr Gly
                645                 650                 655     
Gly Lys Lys Val Ile Gln Thr Asp Glu Trp Arg Asn Gly Pro Val Glu
            660                 665                 670         
Glu Arg Leu Glu Tyr Ala Leu Val Lys Gly Ile Glu Lys His Ile Ile
        675                 680                 685             
Glu Asp Thr Glu Glu Ala Arg Leu Asn Gln Lys Lys Tyr Pro Arg Pro
    690                 695                 700                 
Leu Asn Ile Ile Glu Gly Pro Leu Met Asn Gly Met Lys Ile Val Gly
705                 710                 715                 720 
Asp Leu Phe Gly Ala Gly Lys Met Phe Leu Pro Gln Val Ile Lys Ser
                725                 730                 735     
Ala Arg Val Met Lys Lys Ala Val Gly His Leu Ile Pro Phe Met Glu
            740                 745                 750         
Lys Glu Arg Glu Glu Thr Arg Val Leu Asn Gly Thr Val Glu Glu Glu
        755                 760                 765             
Asp Pro Tyr Gln Gly Thr Ile Val Leu Ala Thr Val Lys Gly Asp Val
    770                 775                 780                 
His Asp Ile Gly Lys Asn Ile Val Gly Val Val Leu Gly Cys Asn Asn
785                 790                 795                 800 
Phe Arg Val Ile Asp Leu Gly Val Met Thr Pro Cys Asp Lys Ile Leu
                805                 810                 815     
Lys Ala Ala Leu Asp His Lys Ala Asp Ile Ile Gly Leu Ser Gly Leu
            820                 825                 830         
Ile Thr Pro Ser Leu Asp Glu Met Ile Phe Val Ala Lys Glu Met Glu
        835                 840                 845             
Arg Leu Ala Ile Arg Ile Pro Leu Leu Ile Gly Gly Ala Thr Thr Ser
    850                 855                 860                 
Lys Thr His Thr Ala Val Lys Ile Ala Pro Arg Tyr Ser Ala Pro Val
865                 870                 875                 880 
Ile His Val Leu Asp Ala Ser Lys Ser Val Val Val Cys Ser Gln Leu
                885                 890                 895     
Leu Asp Glu Asn Leu Lys Asp Glu Tyr Phe Glu Glu Ile Met Glu Glu
            900                 905                 910         
Tyr Glu Asp Ile Arg Gln Asp His Tyr Glu Ser Leu Lys Glu Arg Arg
        915                 920                 925             
Tyr Leu Pro Leu Ser Gln Ala Arg Lys Ser Gly Phe Gln Met Asp Trp
    930                 935                 940                 
Leu Ser Glu Pro His Pro Val Lys Pro Thr Phe Ile Gly Thr Gln Val
945                 950                 955                 960 
Phe Glu Asp Tyr Asp Leu Gln Lys Leu Val Asp Tyr Ile Asp Trp Lys
                965                 970                 975     
Pro Phe Phe Asp Val Trp Gln Leu Arg Gly Lys Tyr Pro Asn Arg Gly
            980                 985                 990         
Phe Pro Lys Ile Phe Asn Asp Lys Thr Val Gly Gly Glu Ala Arg Lys
        995                 1000                1005            
Val Tyr Asp Asp Ala His Asn Met Leu Asn Thr Leu Ile Ser Gln Lys
    1010                1015                1020                
Lys Leu Arg Ala Arg Gly Val Val Gly Phe Trp Pro Ala Gln Ser Ile
1025                1030                1035                1040
Gln Asp Asp Ile His Leu Tyr Ala Glu Ala Ala Val Pro Gln Ala Ala
                1045                1050                1055    
Glu Pro Ile Ala Thr Phe Tyr Gly Leu Arg Gln Gln Ala Glu Lys Asp
            1060                1065                1070        
Ser Ala Ser Thr Glu Pro Tyr Tyr Cys Leu Ser Asp Phe Ile Ala Pro
        1075                1080                1085            
Leu His Ser Gly Ile Arg Asp Tyr Leu Gly Leu Phe Ala Val Ala Cys
    1090                1095                1100                
Phe Gly Val Glu Glu Leu Ser Lys Ala Tyr Glu Asp Asp Gly Asp Asp
1105                1110                1115                1120
Tyr Ser Ser Ile Met Val Lys Ala Leu Gly Asp Arg Leu Ala Glu Ala
                1125                1130                1135    
Phe Ala Glu Glu Leu His Glu Arg Val Arg Arg Glu Leu Trp Ala Tyr
            1140                1145                1150        
Cys Gly Ser Glu Gln Leu Asp Val Ala Asp Leu Arg Arg Leu Arg Tyr
        1155                1160                1165            
Lys Gly Ile Arg Pro Ala Pro Gly Tyr Pro Ser Gln Pro Asp His Thr
    1170                1175                1180                
Glu Lys Leu Thr Met Trp Arg Leu Ala Asp Ile Glu Gln Ser Thr Gly
1185                1190                1195                1200
Ile Arg Leu Thr Glu Ser Leu Ala Met Ala Pro Ala Ser Ala Val Ser
                1205                1210                1215    
Gly Leu Tyr Phe Ser Asn Leu Lys Ser Lys Tyr Phe Ala Val Gly Lys
            1220                1225                1230        
Ile Ser Lys Asp Gln Val Glu Asp Tyr Ala Leu Arg Lys Asn Ile Ser
        1235                1240                1245            
Val Ala Glu Val Glu Lys Trp Leu Gly Pro Ile Leu Gly Tyr Asp Thr
    1250                1255                1260                
Asp
1265


<210> 552
<211> 750
<212> PRT
<213> Homo sapiens

<400> 552
Met Leu Arg Ala Lys Asn Gln Leu Phe Leu Leu Ser Pro His Tyr Leu
 1               5                  10                  15      
Arg Gln Val Lys Glu Ser Ser Gly Ser Arg Leu Ile Gln Gln Arg Leu
            20                  25                  30          
Leu His Gln Gln Gln Pro Leu His Pro Glu Trp Ala Ala Leu Ala Lys
        35                  40                  45              
Lys Gln Leu Lys Gly Lys Asn Pro Glu Asp Leu Ile Trp His Thr Pro
    50                  55                  60                  
Glu Gly Ile Ser Ile Lys Pro Leu Tyr Ser Lys Arg Asp Thr Met Asp
65                  70                  75                  80  
Leu Pro Glu Glu Leu Pro Gly Val Lys Pro Phe Thr Arg Gly Pro Tyr
                85                  90                  95      
Pro Thr Met Tyr Thr Phe Arg Pro Trp Thr Ile Arg Gln Tyr Ala Gly
            100                 105                 110         
Phe Ser Thr Val Glu Glu Ser Asn Lys Phe Tyr Lys Asp Asn Ile Lys
        115                 120                 125             
Ala Gly Gln Gln Gly Leu Ser Val Ala Phe Asp Leu Ala Thr His Arg
    130                 135                 140                 
Gly Tyr Asp Ser Asp Asn Pro Arg Val Arg Gly Asp Val Gly Met Ala
145                 150                 155                 160 
Gly Val Ala Ile Asp Thr Val Glu Asp Thr Lys Ile Leu Phe Asp Gly
                165                 170                 175     
Ile Pro Leu Glu Lys Met Ser Val Ser Met Thr Met Asn Gly Ala Val
            180                 185                 190         
Ile Pro Val Leu Ala Asn Phe Ile Val Thr Gly Glu Glu Gln Gly Val
        195                 200                 205             
Pro Lys Glu Lys Leu Thr Gly Thr Ile Gln Asn Asp Ile Leu Lys Glu
    210                 215                 220                 
Phe Met Val Arg Asn Thr Tyr Ile Phe Pro Pro Glu Pro Ser Met Lys
225                 230                 235                 240 
Ile Ile Ala Asp Ile Phe Glu Tyr Thr Ala Lys His Met Pro Lys Phe
                245                 250                 255     
Asn Ser Ile Ser Ile Ser Gly Tyr His Met Gln Glu Ala Gly Ala Asp
            260                 265                 270         
Ala Ile Leu Glu Leu Ala Tyr Thr Leu Ala Asp Gly Leu Glu Tyr Ser
        275                 280                 285             
Arg Thr Gly Leu Gln Ala Gly Leu Thr Ile Asp Glu Phe Ala Pro Arg
    290                 295                 300                 
Leu Ser Phe Phe Trp Gly Ile Gly Met Asn Phe Tyr Met Glu Ile Ala
305                 310                 315                 320 
Lys Met Arg Ala Gly Arg Arg Leu Trp Ala His Leu Ile Glu Lys Met
                325                 330                 335     
Phe Gln Pro Lys Asn Ser Lys Ser Leu Leu Leu Arg Ala His Cys Gln
            340                 345                 350         
Thr Ser Gly Trp Ser Leu Thr Glu Gln Asp Pro Tyr Asn Asn Ile Val
        355                 360                 365             
Arg Thr Ala Ile Glu Ala Met Ala Ala Val Phe Gly Gly Thr Gln Ser
    370                 375                 380                 
Leu His Thr Asn Ser Phe Asp Glu Ala Leu Gly Leu Pro Thr Val Lys
385                 390                 395                 400 
Ser Ala Arg Ile Ala Arg Asn Thr Gln Ile Ile Ile Gln Glu Glu Ser
                405                 410                 415     
Gly Ile Pro Lys Val Ala Asp Pro Trp Gly Gly Ser Tyr Met Met Glu
            420                 425                 430         
Cys Leu Thr Asn Asp Val Tyr Asp Ala Ala Leu Lys Leu Ile Asn Glu
        435                 440                 445             
Ile Glu Glu Met Gly Gly Met Ala Lys Ala Val Ala Glu Gly Ile Pro
    450                 455                 460                 
Lys Leu Arg Ile Glu Glu Cys Ala Ala Arg Arg Gln Ala Arg Ile Asp
465                 470                 475                 480 
Ser Gly Ser Glu Val Ile Val Gly Val Asn Lys Tyr Gln Leu Glu Lys
                485                 490                 495     
Glu Asp Ala Val Glu Val Leu Ala Ile Asp Asn Thr Ser Val Arg Asn
            500                 505                 510         
Arg Gln Ile Glu Lys Leu Lys Lys Ile Lys Ser Ser Arg Asp Gln Ala
        515                 520                 525             
Leu Ala Glu His Cys Leu Ala Ala Leu Thr Glu Cys Ala Ala Ser Gly
    530                 535                 540                 
Asp Gly Asn Ile Leu Ala Leu Ala Val Asp Ala Ser Arg Ala Arg Cys
545                 550                 555                 560 
Thr Val Gly Glu Ile Thr Asp Ala Leu Lys Lys Val Phe Gly Glu His
                565                 570                 575     
Lys Ala Asn Asp Arg Met Val Ser Gly Ala Tyr Arg Gln Glu Phe Gly
            580                 585                 590         
Glu Ser Lys Glu Ile Thr Ser Ala Ile Lys Arg Val His Lys Phe Met
        595                 600                 605             
Glu Arg Glu Gly Arg Arg Pro Arg Leu Leu Val Ala Lys Met Gly Gln
    610                 615                 620                 
Asp Gly His Asp Arg Gly Ala Lys Val Ile Ala Thr Gly Phe Ala Asp
625                 630                 635                 640 
Leu Gly Phe Asp Val Asp Ile Gly Pro Leu Phe Gln Thr Pro Arg Glu
                645                 650                 655     
Val Ala Gln Gln Ala Val Asp Ala Asp Val His Ala Val Gly Val Ser
            660                 665                 670         
Thr Leu Ala Ala Gly His Lys Thr Leu Val Pro Glu Leu Ile Lys Glu
        675                 680                 685             
Leu Asn Ser Leu Gly Arg Pro Asp Ile Leu Val Met Cys Gly Gly Val
    690                 695                 700                 
Ile Pro Pro Gln Asp Tyr Glu Phe Leu Phe Glu Val Gly Val Ser Asn
705                 710                 715                 720 
Val Phe Gly Pro Gly Thr Arg Ile Pro Lys Ala Ala Val Gln Val Leu
                725                 730                 735     
Asp Asp Ile Glu Lys Cys Leu Glu Lys Lys Gln Gln Ser Val
            740                 745                 750 


<210> 553
<211> 396
<212> PRT
<213> Homo sapiens

<400> 553
Met Leu Ser Glu Val Leu Leu Val Ser Ala Pro Gly Lys Val Ile Leu
 1               5                  10                  15      
His Gly Glu His Ala Val Val His Gly Lys Val Ala Leu Ala Val Ser
            20                  25                  30          
Leu Asn Leu Arg Thr Phe Leu Arg Leu Gln Pro His Ser Asn Gly Lys
        35                  40                  45              
Val Asp Leu Ser Leu Pro Asn Ile Gly Ile Lys Arg Ala Trp Asp Val
    50                  55                  60                  
Ala Arg Leu Gln Ser Leu Asp Thr Ser Phe Leu Glu Gln Gly Asp Val
65                  70                  75                  80  
Thr Thr Pro Thr Ser Glu Gln Val Glu Lys Leu Lys Glu Val Ala Gly
                85                  90                  95      
Leu Pro Asp Asp Cys Ala Val Thr Glu Arg Leu Ala Val Leu Ala Phe
            100                 105                 110         
Leu Tyr Leu Tyr Leu Ser Ile Cys Arg Lys Gln Arg Ala Leu Pro Ser
        115                 120                 125             
Leu Asp Ile Val Val Trp Ser Glu Leu Pro Pro Gly Ala Gly Leu Gly
    130                 135                 140                 
Ser Ser Ala Ala Tyr Ser Val Cys Leu Ala Ala Ala Leu Leu Thr Val
145                 150                 155                 160 
Cys Glu Glu Ile Pro Asn Pro Leu Lys Asp Gly Asp Cys Val Asn Arg
                165                 170                 175     
Trp Thr Lys Glu Asp Leu Glu Leu Ile Asn Lys Trp Ala Phe Gln Gly
            180                 185                 190         
Glu Arg Met Ile His Gly Asn Pro Ser Gly Val Asp Asn Ala Val Ser
        195                 200                 205             
Thr Trp Gly Gly Ala Leu Arg Tyr His Gln Gly Lys Ile Ser Ser Leu
    210                 215                 220                 
Lys Arg Ser Pro Ala Leu Gln Ile Leu Leu Thr Asn Thr Lys Val Pro
225                 230                 235                 240 
Arg Asn Thr Arg Ala Leu Val Ala Gly Val Arg Asn Arg Leu Leu Lys
                245                 250                 255     
Phe Pro Glu Ile Val Ala Pro Leu Leu Thr Ser Ile Asp Ala Ile Ser
            260                 265                 270         
Leu Glu Cys Glu Arg Val Leu Gly Glu Met Gly Glu Ala Pro Ala Pro
        275                 280                 285             
Glu Gln Tyr Leu Val Leu Glu Glu Leu Ile Asp Met Asn Gln His His
    290                 295                 300                 
Leu Asn Ala Leu Gly Val Gly His Ala Ser Leu Asp Gln Leu Cys Gln
305                 310                 315                 320 
Val Thr Arg Ala Arg Gly Leu His Ser Lys Leu Thr Gly Ala Gly Gly
                325                 330                 335     
Gly Gly Cys Gly Ile Thr Leu Leu Lys Pro Gly Leu Glu Gln Pro Glu
            340                 345                 350         
Val Glu Ala Thr Lys Gln Ala Leu Thr Ser Cys Gly Phe Asp Cys Leu
        355                 360                 365             
Glu Thr Ser Ile Gly Ala Pro Gly Val Ser Ile His Ser Ala Thr Ser
    370                 375                 380                 
Leu Asp Ser Arg Val Gln Gln Ala Leu Asp Gly Leu
385                 390                 395     


<210> 554
<211> 1274
<212> PRT
<213> Homo sapiens

<400> 554
Met Pro Glu Pro Gly Lys Lys Pro Val Ser Ala Phe Ser Lys Lys Pro
 1               5                  10                  15      
Arg Ser Val Glu Val Ala Ala Gly Ser Pro Ala Val Phe Glu Ala Glu
            20                  25                  30          
Thr Glu Arg Ala Gly Val Lys Val Arg Trp Gln Arg Gly Gly Ser Asp
        35                  40                  45              
Ile Ser Ala Ser Asn Lys Tyr Gly Leu Ala Thr Glu Gly Thr Arg His
    50                  55                  60                  
Thr Leu Thr Val Arg Glu Val Gly Pro Ala Asp Gln Gly Ser Tyr Ala
65                  70                  75                  80  
Val Ile Ala Gly Ser Ser Lys Val Lys Phe Asp Leu Lys Val Ile Glu
                85                  90                  95      
Ala Glu Lys Ala Glu Pro Met Leu Ala Pro Ala Pro Ala Pro Ala Glu
            100                 105                 110         
Ala Thr Gly Ala Pro Gly Glu Ala Pro Ala Pro Ala Ala Glu Leu Gly
        115                 120                 125             
Glu Ser Ala Pro Ser Pro Lys Gly Ser Ser Ser Ala Ala Leu Asn Gly
    130                 135                 140                 
Pro Thr Pro Gly Ala Pro Asp Asp Pro Ile Gly Leu Phe Val Met Arg
145                 150                 155                 160 
Pro Gln Asp Gly Glu Val Thr Val Gly Gly Ser Ile Thr Phe Ser Ala
                165                 170                 175     
Arg Val Ala Gly Ala Ser Leu Leu Lys Pro Pro Val Val Lys Trp Phe
            180                 185                 190         
Lys Gly Lys Trp Val Asp Leu Ser Ser Lys Val Gly Gln His Leu Gln
        195                 200                 205             
Leu His Asp Ser Tyr Asp Arg Ala Ser Lys Val Tyr Leu Phe Glu Leu
    210                 215                 220                 
His Ile Thr Asp Ala Gln Pro Ala Phe Thr Gly Ser Tyr Arg Cys Glu
225                 230                 235                 240 
Val Ser Thr Lys Asp Lys Phe Glu Cys Ser Asn Phe Asn Leu Thr Val
                245                 250                 255     
His Glu Ala Met Gly Thr Gly Asp Leu Asp Leu Leu Ser Ala Phe Arg
            260                 265                 270         
Arg Thr Ser Leu Ala Gly Gly Gly Arg Arg Ile Ser Asp Ser His Glu
        275                 280                 285             
Asp Thr Gly Ile Leu Asp Phe Ser Ser Leu Leu Lys Lys Arg Asp Ser
    290                 295                 300                 
Phe Arg Thr Pro Arg Asp Ser Lys Leu Glu Ala Pro Ala Glu Glu Asp
305                 310                 315                 320 
Val Trp Glu Ile Leu Arg Gln Ala Pro Pro Ser Glu Tyr Glu Arg Ile
                325                 330                 335     
Ala Phe Gln Tyr Gly Val Thr Asp Leu Arg Gly Met Leu Lys Arg Leu
            340                 345                 350         
Lys Gly Met Arg Arg Asp Glu Lys Lys Ser Thr Ala Phe Gln Lys Lys
        355                 360                 365             
Leu Glu Pro Ala Tyr Gln Val Ser Lys Gly His Lys Ile Arg Leu Thr
    370                 375                 380                 
Val Glu Leu Ala Asp His Asp Ala Glu Val Lys Trp Leu Lys Asn Gly
385                 390                 395                 400 
Gln Glu Ile Gln Met Ser Gly Ser Lys Tyr Ile Phe Glu Ser Ile Gly
                405                 410                 415     
Ala Lys Arg Thr Leu Thr Ile Ser Gln Cys Ser Leu Ala Asp Asp Ala
            420                 425                 430         
Ala Tyr Gln Cys Val Val Gly Gly Glu Lys Cys Ser Thr Glu Leu Phe
        435                 440                 445             
Val Lys Glu Pro Pro Val Leu Ile Thr Arg Pro Leu Glu Asp Gln Leu
    450                 455                 460                 
Val Met Val Gly Gln Arg Val Glu Phe Glu Cys Glu Val Ser Glu Glu
465                 470                 475                 480 
Gly Ala Gln Val Lys Trp Leu Lys Asp Gly Val Glu Leu Thr Arg Glu
                485                 490                 495     
Glu Thr Phe Lys Tyr Arg Phe Lys Lys Asp Gly Gln Arg His His Leu
            500                 505                 510         
Ile Ile Asn Glu Ala Met Leu Glu Asp Ala Gly His Tyr Ala Leu Cys
        515                 520                 525             
Thr Ser Gly Gly Gln Ala Leu Arg Glu Leu Ile Val Gln Glu Lys Lys
    530                 535                 540                 
Leu Glu Val Tyr Gln Ser Ile Ala Asp Leu Met Val Gly Ala Lys Asp
545                 550                 555                 560 
Gln Ala Val Phe Lys Cys Glu Val Ser Asp Glu Asn Val Arg Gly Val
                565                 570                 575     
Trp Leu Lys Asn Gly Lys Glu Leu Val Pro Asp Ser Arg Ile Lys Val
            580                 585                 590         
Ser His Ile Gly Arg Val His Lys Leu Thr Ile Asp Asp Val Thr Pro
        595                 600                 605             
Ala Asp Glu Ala Asp Tyr Ser Phe Val Pro Glu Gly Phe Ala Cys Asn
    610                 615                 620                 
Leu Ser Ala Lys Leu His Phe Met Glu Val Lys Ile Asp Phe Val Pro
625                 630                 635                 640 
Arg Gln Glu Pro Pro Lys Ile His Leu Asp Cys Pro Gly Arg Ile Pro
                645                 650                 655     
Asp Thr Ile Val Val Val Ala Gly Asn Lys Leu Arg Leu Asp Val Pro
            660                 665                 670         
Ile Ser Gly Asp Pro Ala Pro Thr Val Ile Trp Gln Lys Ala Ile Thr
        675                 680                 685             
Gln Gly Asn Lys Ala Pro Ala Arg Pro Ala Pro Asp Ala Pro Glu Asp
    690                 695                 700                 
Thr Gly Asp Ser Asp Glu Trp Val Phe Asp Lys Lys Leu Leu Cys Glu
705                 710                 715                 720 
Thr Glu Gly Arg Val Arg Val Glu Thr Thr Lys Asp Arg Ser Ile Phe
                725                 730                 735     
Thr Val Glu Gly Ala Glu Lys Glu Asp Glu Gly Val Tyr Thr Val Thr
            740                 745                 750         
Val Lys Asn Pro Val Gly Glu Asp Gln Val Asn Leu Thr Val Lys Val
        755                 760                 765             
Ile Asp Val Pro Asp Ala Pro Ala Ala Pro Lys Ile Ser Asn Val Gly
    770                 775                 780                 
Glu Asp Ser Cys Thr Val Gln Trp Glu Pro Pro Ala Tyr Asp Gly Gly
785                 790                 795                 800 
Gln Pro Ile Leu Gly Tyr Ile Leu Glu Arg Lys Lys Lys Lys Ser Tyr
                805                 810                 815     
Arg Trp Met Gln Leu Asn Phe Asp Leu Ile Gln Glu Leu Ser His Glu
            820                 825                 830         
Ala Arg Arg Met Ile Glu Gly Val Val Tyr Glu Met Arg Val Tyr Ala
        835                 840                 845             
Val Asn Ala Ile Gly Met Ser Arg Pro Ser Pro Ala Ser Gln Pro Phe
    850                 855                 860                 
Met Pro Ile Gly Pro Pro Ser Glu Pro Thr His Leu Ala Val Glu Asp
865                 870                 875                 880 
Val Ser Asp Thr Thr Val Ser Leu Lys Trp Arg Pro Pro Glu Arg Val
                885                 890                 895     
Gly Ala Gly Gly Leu Asp Gly Tyr Ser Val Glu Tyr Cys Pro Glu Gly
            900                 905                 910         
Cys Ser Glu Trp Val Ala Ala Leu Gln Gly Leu Thr Glu His Thr Ser
        915                 920                 925             
Ile Leu Val Lys Asp Leu Pro Thr Gly Ala Arg Leu Leu Phe Arg Val
    930                 935                 940                 
Arg Ala His Asn Met Ala Gly Pro Gly Ala Pro Val Thr Thr Thr Glu
945                 950                 955                 960 
Pro Val Thr Val Gln Glu Ile Leu Gln Arg Pro Arg Leu Gln Leu Pro
                965                 970                 975     
Arg His Leu Arg Gln Thr Ile Gln Lys Lys Val Gly Glu Pro Val Asn
            980                 985                 990         
Leu Leu Ile Pro Phe Gln Gly Lys Pro Arg Pro Gln Val Thr Trp Thr
        995                 1000                1005            
Lys Glu Gly Gln Pro Leu Ala Gly Glu Glu Val Ser Ile Arg Asn Ser
    1010                1015                1020                
Pro Thr Asp Thr Ile Leu Phe Ile Arg Ala Ala Arg Arg Val His Ser
1025                1030                1035                1040
Gly Thr Tyr Gln Val Thr Val Arg Ile Glu Asn Met Glu Asp Lys Ala
                1045                1050                1055    
Thr Leu Val Leu Gln Val Val Asp Lys Pro Ser Pro Pro Gln Asp Leu
            1060                1065                1070        
Arg Val Thr Asp Ala Trp Gly Leu Asn Val Ala Leu Glu Trp Lys Pro
        1075                1080                1085            
Pro Gln Asp Val Gly Asn Thr Glu Leu Trp Gly Tyr Thr Val Gln Lys
    1090                1095                1100                
Ala Asp Lys Lys Thr Met Glu Trp Phe Thr Val Leu Glu His Tyr Arg
1105                1110                1115                1120
Arg Thr His Cys Val Val Pro Glu Leu Ile Ile Gly Asn Gly Tyr Tyr
                1125                1130                1135    
Phe Arg Val Phe Ser Gln Asn Met Val Gly Phe Ser Asp Arg Ala Ala
            1140                1145                1150        
Thr Thr Lys Glu Pro Val Phe Ile Pro Arg Pro Gly Ile Thr Tyr Glu
        1155                1160                1165            
Pro Pro Asn Tyr Lys Ala Leu Asp Phe Ser Glu Ala Pro Ser Phe Thr
    1170                1175                1180                
Gln Pro Leu Val Asn Arg Ser Val Ile Ala Gly Tyr Thr Ala Met Leu
1185                1190                1195                1200
Cys Cys Ala Val Arg Gly Ser Pro Lys Pro Lys Ile Ser Trp Phe Lys
                1205                1210                1215    
Asn Gly Leu Asp Leu Gly Glu Asp Ala Arg Phe Arg Met Phe Ser Lys
            1220                1225                1230        
Gln Gly Val Leu Thr Leu Glu Ile Arg Lys Pro Cys Pro Phe Asp Gly
        1235                1240                1245            
Gly Ile Tyr Val Cys Arg Ala Thr Asn Leu Gln Gly Glu Ala Arg Cys
    1250                1255                1260                
Glu Cys Arg Leu Glu Val Arg Val Pro Gln
1265                1270                


<210> 555
<211> 166
<212> PRT
<213> Homo sapiens

<400> 555
Met Ala Pro Lys Lys Ala Lys Lys Arg Ala Gly Gly Ala Asn Ser Asn
 1               5                  10                  15      
Val Phe Ser Met Phe Glu Gln Thr Gln Ile Gln Glu Phe Lys Glu Ala
            20                  25                  30          
Phe Thr Ile Met Asp Gln Asn Arg Asp Gly Phe Ile Asp Lys Asn Asp
        35                  40                  45              
Leu Arg Asp Thr Phe Ala Ala Leu Gly Arg Val Asn Val Lys Asn Glu
    50                  55                  60                  
Glu Ile Asp Glu Met Ile Lys Glu Ala Pro Gly Pro Ile Asn Phe Thr
65                  70                  75                  80  
Val Phe Leu Ser Met Phe Gly Glu Lys Leu Lys Gly Ala Asp Pro Glu
                85                  90                  95      
Glu Thr Ile Leu Asn Ala Phe Lys Val Phe Asp Pro Glu Gly Lys Gly
            100                 105                 110         
Val Leu Lys Ala Asp Tyr Val Arg Glu Met Leu Thr Thr Gln Ala Glu
        115                 120                 125             
Arg Phe Ser Lys Glu Glu Val Asp Gln Met Phe Ala Ala Phe Pro Pro
    130                 135                 140                 
Asp Val Thr Gly Asn Leu Asp Tyr Lys Asn Leu Val His Ile Ile Thr
145                 150                 155                 160 
His Gly Glu Glu Lys Asp
                165     


<210> 556
<211> 520
<212> PRT
<213> Homo sapiens

<400> 556
Met Ala Ala Leu Lys Leu Leu Ser Ser Gly Leu Arg Leu Cys Ala Ser
 1               5                  10                  15      
Ala Arg Gly Ser Gly Ala Thr Trp Tyr Lys Gly Cys Val Cys Ser Phe
            20                  25                  30          
Ser Thr Ser Ala His Arg His Thr Lys Phe Tyr Thr Asp Pro Val Glu
        35                  40                  45              
Ala Val Lys Asp Ile Pro Asp Gly Ala Thr Val Leu Val Gly Gly Phe
    50                  55                  60                  
Gly Leu Cys Gly Ile Pro Glu Asn Leu Ile Asp Ala Leu Leu Lys Thr
65                  70                  75                  80  
Gly Val Lys Gly Leu Thr Ala Val Ser Asn Asn Ala Gly Val Asp Asn
                85                  90                  95      
Phe Gly Leu Gly Leu Leu Leu Arg Ser Lys Gln Ile Lys Arg Met Val
            100                 105                 110         
Ser Ser Tyr Val Gly Glu Asn Ala Glu Phe Glu Arg Gln Tyr Leu Ser
        115                 120                 125             
Gly Glu Leu Glu Val Glu Leu Thr Pro Gln Gly Thr Leu Ala Glu Arg
    130                 135                 140                 
Ile Arg Ala Gly Gly Ala Gly Val Pro Ala Phe Tyr Thr Pro Thr Gly
145                 150                 155                 160 
Tyr Gly Thr Leu Val Gln Glu Gly Gly Ser Pro Ile Lys Tyr Asn Lys
                165                 170                 175     
Asp Gly Ser Val Ala Ile Ala Ser Lys Pro Arg Glu Val Arg Glu Phe
            180                 185                 190         
Asn Gly Gln His Phe Ile Leu Glu Glu Ala Ile Thr Gly Asp Phe Ala
        195                 200                 205             
Leu Val Lys Ala Trp Lys Ala Asp Arg Ala Gly Asn Val Ile Phe Arg
    210                 215                 220                 
Lys Ser Ala Arg Asn Phe Asn Leu Pro Met Cys Lys Ala Ala Glu Thr
225                 230                 235                 240 
Thr Val Val Glu Val Glu Glu Ile Val Asp Ile Gly Ala Phe Ala Pro
                245                 250                 255     
Glu Asp Ile His Ile Pro Gln Ile Tyr Val His Arg Leu Ile Lys Gly
            260                 265                 270         
Glu Lys Tyr Glu Lys Arg Ile Glu Arg Leu Ser Ile Arg Lys Glu Gly
        275                 280                 285             
Asp Gly Glu Ala Lys Ser Ala Lys Pro Gly Asp Asp Val Arg Glu Arg
    290                 295                 300                 
Ile Ile Lys Arg Ala Ala Leu Glu Phe Glu Asp Gly Met Tyr Ala Asn
305                 310                 315                 320 
Leu Gly Ile Gly Ile Pro Leu Leu Ala Ser Asn Phe Ile Ser Pro Asn
                325                 330                 335     
Ile Thr Val His Leu Gln Ser Glu Asn Gly Val Leu Gly Leu Gly Pro
            340                 345                 350         
Tyr Pro Arg Gln His Glu Ala Asp Ala Asp Leu Ile Asn Ala Gly Lys
        355                 360                 365             
Glu Thr Val Thr Ile Leu Pro Gly Ala Ser Phe Phe Ser Ser Asp Glu
    370                 375                 380                 
Ser Phe Ala Met Ile Arg Gly Gly His Val Asp Leu Thr Met Leu Gly
385                 390                 395                 400 
Ala Met Gln Val Ser Lys Tyr Gly Asp Leu Ala Asn Trp Met Ile Pro
                405                 410                 415     
Gly Lys Met Val Lys Gly Met Gly Gly Ala Met Asp Leu Val Ser Ser
            420                 425                 430         
Ala Lys Thr Lys Val Val Val Thr Met Glu His Ser Ala Lys Gly Asn
        435                 440                 445             
Ala His Lys Ile Met Glu Lys Cys Thr Leu Pro Leu Thr Gly Lys Gln
    450                 455                 460                 
Cys Val Asn Arg Ile Ile Thr Glu Lys Ala Val Phe Asp Val Asp Lys
465                 470                 475                 480 
Lys Lys Gly Leu Thr Leu Ile Glu Leu Trp Glu Gly Leu Thr Val Asp
                485                 490                 495     
Asp Val Gln Lys Ser Thr Gly Cys Asp Phe Ala Val Ser Pro Lys Leu
            500                 505                 510         
Met Pro Met Gln Gln Ile Ala Asn
        515                 520 


<210> 557
<211> 520
<212> PRT
<213> Homo sapiens

<400> 557
Met Ala Ala Leu Lys Leu Leu Ser Ser Gly Leu Arg Leu Cys Ala Ser
 1               5                  10                  15      
Ala Arg Gly Ser Gly Ala Thr Trp Tyr Lys Gly Cys Val Cys Ser Phe
            20                  25                  30          
Ser Thr Ser Ala His Arg His Thr Lys Phe Tyr Thr Asp Pro Val Glu
        35                  40                  45              
Ala Val Lys Asp Ile Pro Asp Gly Ala Thr Val Leu Val Gly Gly Phe
    50                  55                  60                  
Gly Leu Cys Gly Ile Pro Glu Asn Leu Ile Asp Ala Leu Leu Lys Thr
65                  70                  75                  80  
Gly Val Lys Gly Leu Thr Ala Val Ser Asn Asn Ala Gly Val Asp Asn
                85                  90                  95      
Phe Gly Leu Gly Leu Leu Leu Arg Ser Lys Gln Ile Lys Arg Met Val
            100                 105                 110         
Ser Ser Tyr Val Gly Glu Asn Ala Glu Phe Glu Arg Gln Tyr Leu Ser
        115                 120                 125             
Gly Glu Leu Glu Val Glu Leu Thr Pro Gln Gly Thr Leu Ala Glu Arg
    130                 135                 140                 
Ile Arg Ala Gly Gly Ala Gly Val Pro Ala Phe Tyr Thr Pro Thr Gly
145                 150                 155                 160 
Tyr Gly Thr Leu Val Gln Glu Gly Gly Ser Pro Ile Lys Tyr Asn Lys
                165                 170                 175     
Asp Gly Ser Val Ala Ile Ala Ser Lys Pro Arg Glu Val Arg Glu Phe
            180                 185                 190         
Asn Gly Gln His Phe Ile Leu Glu Glu Ala Ile Thr Gly Asp Phe Ala
        195                 200                 205             
Leu Val Lys Ala Trp Lys Ala Asp Arg Ala Gly Asn Val Ile Phe Arg
    210                 215                 220                 
Lys Ser Ala Arg Asn Phe Asn Leu Pro Met Cys Lys Ala Ala Glu Thr
225                 230                 235                 240 
Thr Val Val Glu Val Glu Glu Ile Val Asp Ile Gly Ala Phe Ala Pro
                245                 250                 255     
Glu Asp Ile His Ile Pro Gln Ile Tyr Val His Arg Leu Ile Lys Gly
            260                 265                 270         
Glu Lys Tyr Glu Lys Arg Ile Glu Arg Leu Ser Ile Arg Lys Glu Gly
        275                 280                 285             
Asp Gly Glu Ala Lys Ser Ala Lys Pro Gly Asp Asp Val Arg Glu Arg
    290                 295                 300                 
Ile Ile Lys Arg Ala Ala Leu Glu Phe Glu Asp Gly Met Tyr Ala Asn
305                 310                 315                 320 
Leu Gly Ile Gly Ile Pro Leu Leu Ala Ser Asn Phe Ile Ser Pro Asn
                325                 330                 335     
Ile Thr Val His Leu Gln Ser Glu Asn Gly Val Leu Gly Leu Gly Pro
            340                 345                 350         
Tyr Pro Arg Gln His Glu Ala Asp Ala Asp Leu Ile Asn Ala Gly Lys
        355                 360                 365             
Glu Thr Val Thr Ile Leu Pro Gly Ala Ser Phe Phe Ser Ser Asp Glu
    370                 375                 380                 
Ser Phe Ala Met Ile Arg Gly Gly His Val Asp Leu Thr Met Leu Gly
385                 390                 395                 400 
Ala Met Gln Val Ser Lys Tyr Gly Asp Leu Ala Asn Trp Met Ile Pro
                405                 410                 415     
Gly Lys Met Val Lys Gly Met Gly Gly Ala Met Asp Leu Val Ser Ser
            420                 425                 430         
Ala Lys Thr Lys Val Val Val Thr Met Glu His Ser Ala Lys Gly Asn
        435                 440                 445             
Ala His Lys Ile Met Glu Lys Cys Thr Leu Pro Leu Thr Gly Lys Gln
    450                 455                 460                 
Cys Val Asn Arg Ile Ile Thr Glu Lys Ala Val Phe Asp Val Asp Lys
465                 470                 475                 480 
Lys Lys Gly Leu Thr Leu Ile Glu Leu Trp Glu Gly Leu Thr Val Asp
                485                 490                 495     
Asp Val Gln Lys Ser Thr Gly Cys Asp Phe Ala Val Ser Pro Lys Leu
            500                 505                 510         
Met Pro Met Gln Gln Ile Ala Asn
        515                 520 


<210> 558
<211> 703
<212> PRT
<213> Homo sapiens

<400> 558
Met Leu Ser Ala Ala Leu Arg Thr Leu Lys His Val Leu Tyr Tyr Ser
 1               5                  10                  15      
Arg Gln Cys Leu Met Val Ser Arg Asn Leu Gly Ser Val Gly Tyr Asp
            20                  25                  30          
Pro Asn Glu Lys Thr Phe Asp Lys Ile Leu Val Ala Asn Arg Gly Glu
        35                  40                  45              
Ile Ala Cys Arg Val Ile Arg Thr Cys Lys Lys Met Gly Ile Lys Thr
    50                  55                  60                  
Val Ala Ile His Ser Asp Val Asp Ala Ser Ser Val His Val Lys Met
65                  70                  75                  80  
Ala Asp Glu Ala Val Cys Val Gly Pro Ala Pro Thr Ser Lys Ser Tyr
                85                  90                  95      
Leu Asn Met Asp Ala Ile Met Glu Ala Ile Lys Lys Thr Arg Ala Gln
            100                 105                 110         
Ala Val His Pro Gly Tyr Gly Phe Leu Ser Glu Asn Lys Glu Phe Ala
        115                 120                 125             
Arg Cys Leu Ala Ala Glu Asp Val Val Phe Ile Gly Pro Asp Thr His
    130                 135                 140                 
Ala Ile Gln Ala Met Gly Asp Lys Ile Glu Ser Lys Leu Leu Ala Lys
145                 150                 155                 160 
Lys Ala Glu Val Asn Thr Ile Pro Gly Phe Asp Gly Val Val Lys Asp
                165                 170                 175     
Ala Glu Glu Ala Val Arg Ile Ala Arg Glu Ile Gly Tyr Pro Val Met
            180                 185                 190         
Ile Lys Ala Ser Ala Gly Gly Gly Gly Lys Gly Met Arg Ile Ala Trp
        195                 200                 205             
Asp Asp Glu Glu Thr Arg Asp Gly Phe Arg Leu Ser Ser Gln Glu Ala
    210                 215                 220                 
Ala Ser Ser Phe Gly Asp Asp Arg Leu Leu Ile Glu Lys Phe Ile Asp
225                 230                 235                 240 
Asn Pro Arg His Ile Glu Ile Gln Val Leu Gly Asp Lys His Gly Asn
                245                 250                 255     
Ala Leu Trp Leu Asn Glu Arg Glu Cys Ser Ile Gln Arg Arg Asn Gln
            260                 265                 270         
Lys Val Val Glu Glu Ala Pro Ser Ile Phe Leu Asp Ala Glu Thr Arg
        275                 280                 285             
Arg Ala Met Gly Glu Gln Ala Val Ala Leu Ala Arg Ala Val Lys Tyr
    290                 295                 300                 
Ser Ser Ala Gly Thr Val Glu Phe Leu Val Asp Ser Lys Lys Asn Phe
305                 310                 315                 320 
Tyr Phe Leu Glu Met Asn Thr Arg Leu Gln Val Glu His Pro Val Thr
                325                 330                 335     
Glu Cys Ile Thr Gly Leu Asp Leu Val Gln Glu Met Ile Arg Val Ala
            340                 345                 350         
Lys Gly Tyr Pro Leu Arg His Lys Gln Ala Asp Ile Arg Ile Asn Gly
        355                 360                 365             
Trp Ala Val Glu Cys Arg Val Tyr Ala Glu Asp Pro Tyr Lys Ser Phe
    370                 375                 380                 
Gly Leu Pro Ser Ile Gly Arg Leu Ser Gln Tyr Gln Glu Pro Leu His
385                 390                 395                 400 
Leu Pro Gly Val Arg Val Asp Ser Gly Ile Gln Pro Gly Ser Asp Ile
                405                 410                 415     
Ser Ile Tyr Tyr Asp Pro Met Ile Ser Lys Leu Ile Thr Tyr Gly Ser
            420                 425                 430         
Asp Arg Thr Glu Ala Leu Lys Arg Met Ala Asp Ala Leu Asp Asn Tyr
        435                 440                 445             
Val Ile Arg Gly Val Thr His Asn Ile Ala Leu Leu Arg Glu Val Ile
    450                 455                 460                 
Ile Asn Ser Arg Phe Val Lys Gly Asp Ile Ser Thr Lys Phe Leu Ser
465                 470                 475                 480 
Asp Val Tyr Pro Asp Gly Phe Lys Gly His Met Leu Thr Lys Ser Glu
                485                 490                 495     
Lys Asn Gln Leu Leu Ala Ile Ala Ser Ser Leu Phe Val Ala Phe Gln
            500                 505                 510         
Leu Arg Ala Gln His Phe Gln Glu Asn Ser Arg Met Pro Val Ile Lys
        515                 520                 525             
Pro Asp Ile Ala Asn Trp Glu Leu Ser Val Lys Leu His Asp Lys Val
    530                 535                 540                 
His Thr Val Val Ala Ser Asn Asn Gly Ser Val Phe Ser Val Glu Val
545                 550                 555                 560 
Asp Gly Ser Lys Leu Asn Val Thr Ser Thr Trp Asn Leu Ala Ser Pro
                565                 570                 575     
Leu Leu Ser Val Ser Val Asp Gly Thr Gln Arg Thr Val Gln Cys Leu
            580                 585                 590         
Ser Arg Glu Ala Gly Gly Asn Met Ser Ile Gln Phe Leu Gly Thr Val
        595                 600                 605             
Tyr Lys Val Asn Ile Leu Thr Arg Leu Ala Ala Glu Leu Asn Lys Phe
    610                 615                 620                 
Met Leu Glu Lys Val Thr Glu Asp Thr Ser Ser Val Leu Arg Ser Pro
625                 630                 635                 640 
Met Pro Gly Val Val Val Ala Val Ser Val Lys Pro Gly Asp Ala Val
                645                 650                 655     
Ala Glu Gly Gln Glu Ile Cys Val Ile Glu Ala Met Lys Met Gln Asn
            660                 665                 670         
Ser Met Thr Ala Gly Lys Thr Gly Thr Val Lys Ser Val His Cys Gln
        675                 680                 685             
Ala Gly Asp Thr Val Gly Glu Gly Asp Leu Leu Val Glu Leu Glu
    690                 695                 700             


<210> 559
<211> 389
<212> PRT
<213> Homo sapiens

<400> 559
Met Leu Ser Leu Arg Val Pro Leu Ala Pro Ile Thr Asp Pro Gln Gln
 1               5                  10                  15      
Leu Gln Leu Ser Pro Leu Lys Gly Leu Ser Leu Val Asp Lys Glu Asn
            20                  25                  30          
Thr Pro Pro Ala Leu Ser Gly Thr Arg Val Leu Ala Ser Lys Thr Ala
        35                  40                  45              
Arg Arg Ile Phe Gln Glu Pro Thr Glu Pro Lys Thr Lys Ala Ala Ala
    50                  55                  60                  
Pro Gly Val Glu Asp Glu Pro Leu Leu Arg Glu Asn Pro Arg Arg Phe
65                  70                  75                  80  
Val Ile Phe Pro Ile Glu Tyr His Asp Ile Trp Gln Met Tyr Lys Lys
                85                  90                  95      
Ala Glu Ala Ser Phe Trp Thr Ala Glu Glu Val Asp Leu Ser Lys Asp
            100                 105                 110         
Ile Gln His Trp Glu Ser Leu Lys Pro Glu Glu Arg Tyr Phe Ile Ser
        115                 120                 125             
His Val Leu Ala Phe Phe Ala Ala Ser Asp Gly Ile Val Asn Glu Asn
    130                 135                 140                 
Leu Val Glu Arg Phe Ser Gln Glu Val Gln Ile Thr Glu Ala Arg Cys
145                 150                 155                 160 
Phe Tyr Gly Phe Gln Ile Ala Met Glu Asn Ile His Ser Glu Met Tyr
                165                 170                 175     
Ser Leu Leu Ile Asp Thr Tyr Ile Lys Asp Pro Lys Glu Arg Glu Phe
            180                 185                 190         
Leu Phe Asn Ala Ile Glu Thr Met Pro Cys Val Lys Lys Lys Ala Asp
        195                 200                 205             
Trp Ala Leu Arg Trp Ile Gly Asp Lys Glu Ala Thr Tyr Gly Glu Arg
    210                 215                 220                 
Val Val Ala Phe Ala Ala Val Glu Gly Ile Phe Phe Ser Gly Ser Phe
225                 230                 235                 240 
Ala Ser Ile Phe Trp Leu Lys Lys Arg Gly Leu Met Pro Gly Leu Thr
                245                 250                 255     
Phe Ser Asn Glu Leu Ile Ser Arg Asp Glu Gly Leu His Cys Asp Phe
            260                 265                 270         
Ala Cys Leu Met Phe Lys His Leu Val His Lys Pro Ser Glu Glu Arg
        275                 280                 285             
Val Arg Glu Ile Ile Ile Asn Ala Val Arg Ile Glu Gln Glu Phe Leu
    290                 295                 300                 
Thr Glu Ala Leu Pro Val Lys Leu Ile Gly Met Asn Cys Thr Leu Met
305                 310                 315                 320 
Lys Gln Tyr Ile Glu Phe Val Ala Asp Arg Leu Met Leu Glu Leu Gly
                325                 330                 335     
Phe Ser Lys Val Phe Arg Val Glu Asn Pro Phe Asp Phe Met Glu Asn
            340                 345                 350         
Ile Ser Leu Glu Gly Lys Thr Asn Phe Phe Glu Lys Arg Val Gly Glu
        355                 360                 365             
Tyr Gln Arg Met Gly Val Met Ser Ser Pro Thr Glu Asn Ser Phe Thr
    370                 375                 380                 
Leu Asp Ala Asp Phe
385                 


<210> 560
<211> 488
<212> PRT
<213> Homo sapiens

<400> 560
Met Gly Thr Leu Leu Gly Leu Gly Ala Val Leu Ala Tyr Gln Asp His
 1               5                  10                  15      
Arg Cys Arg Ala Ala Gln Glu Ser Thr His Ile Tyr Thr Lys Glu Glu
            20                  25                  30          
Val Ser Ser His Thr Ser Pro Glu Thr Gly Ile Trp Val Thr Leu Gly
        35                  40                  45              
Ser Glu Val Phe Asp Val Thr Glu Phe Val Asp Leu His Pro Gly Gly
    50                  55                  60                  
Pro Ser Lys Leu Met Leu Ala Ala Gly Gly Pro Leu Glu Pro Phe Trp
65                  70                  75                  80  
Ala Leu Tyr Ala Val His Asn Gln Ser His Val Arg Glu Leu Leu Ala
                85                  90                  95      
Gln Tyr Lys Ile Gly Glu Leu Asn Pro Glu Asp Lys Val Ala Pro Thr
            100                 105                 110         
Val Glu Thr Ser Asp Pro Tyr Ala Asp Asp Pro Val Arg His Pro Ala
        115                 120                 125             
Leu Lys Val Asn Ser Gln Arg Pro Phe Asn Ala Glu Pro Pro Pro Glu
    130                 135                 140                 
Leu Leu Thr Glu Asn Tyr Ile Thr Pro Asn Pro Ile Phe Phe Thr Arg
145                 150                 155                 160 
Asn His Leu Pro Val Pro Asn Leu Asp Pro Asp Thr Tyr Arg Leu His
                165                 170                 175     
Val Val Gly Ala Pro Gly Gly Gln Ser Leu Ser Leu Ser Leu Asp Asp
            180                 185                 190         
Leu His Asn Phe Pro Arg Tyr Glu Ile Thr Val Thr Leu Gln Cys Ala
        195                 200                 205             
Gly Asn Arg Arg Ser Glu Met Thr Gln Val Lys Glu Val Lys Gly Leu
    210                 215                 220                 
Glu Trp Arg Thr Gly Ala Ile Ser Thr Ala Arg Trp Ala Gly Ala Arg
225                 230                 235                 240 
Leu Cys Asp Val Leu Ala Gln Ala Gly His Gln Leu Cys Glu Thr Glu
                245                 250                 255     
Ala His Val Cys Phe Glu Gly Leu Asp Ser Asp Pro Thr Gly Thr Ala
            260                 265                 270         
Tyr Gly Ala Ser Ile Pro Leu Ala Arg Ala Met Asp Pro Glu Ala Glu
        275                 280                 285             
Val Leu Leu Ala Tyr Glu Met Asn Gly Gln Pro Leu Pro Arg Asp His
    290                 295                 300                 
Gly Phe Pro Val Arg Val Val Val Pro Gly Val Val Gly Ala Arg His
305                 310                 315                 320 
Val Lys Trp Leu Gly Arg Val Ser Val Gln Pro Glu Glu Ser Tyr Ser
                325                 330                 335     
His Trp Gln Arg Arg Asp Tyr Lys Gly Phe Ser Pro Ser Val Asp Trp
            340                 345                 350         
Glu Thr Val Asp Phe Asp Ser Ala Pro Ser Ile Gln Glu Leu Pro Val
        355                 360                 365             
Gln Ser Ala Ile Thr Glu Pro Arg Asp Gly Glu Thr Val Glu Ser Gly
    370                 375                 380                 
Glu Val Thr Ile Lys Gly Tyr Ala Trp Ser Gly Gly Gly Arg Ala Val
385                 390                 395                 400 
Ile Arg Val Asp Val Ser Leu Asp Gly Gly Leu Thr Trp Gln Val Ala
                405                 410                 415     
Lys Leu Asp Gly Glu Glu Gln Arg Pro Arg Lys Ala Trp Ala Trp Arg
            420                 425                 430         
Leu Trp Gln Leu Lys Ala Pro Val Pro Ala Gly Gln Lys Glu Leu Asn
        435                 440                 445             
Ile Val Cys Lys Ala Val Asp Asp Gly Tyr Asn Val Gln Pro Asp Thr
    450                 455                 460                 
Val Ala Pro Ile Trp Asn Leu Arg Gly Val Leu Ser Asn Ala Trp His
465                 470                 475                 480 
Arg Val His Val Tyr Val Ser Pro
                485             


<210> 561
<211> 488
<212> PRT
<213> Homo sapiens

<400> 561
Met Gly Thr Leu Leu Gly Leu Gly Ala Val Leu Ala Tyr Gln Asp His
 1               5                  10                  15      
Arg Cys Arg Ala Ala Gln Glu Ser Thr His Ile Tyr Thr Lys Glu Glu
            20                  25                  30          
Val Ser Ser His Thr Ser Pro Glu Thr Gly Ile Trp Val Thr Leu Gly
        35                  40                  45              
Ser Glu Val Phe Asp Val Thr Glu Phe Val Asp Leu His Pro Gly Gly
    50                  55                  60                  
Pro Ser Lys Leu Met Leu Ala Ala Gly Gly Pro Leu Glu Pro Phe Trp
65                  70                  75                  80  
Ala Leu Tyr Ala Val His Asn Gln Ser His Val Arg Glu Leu Leu Ala
                85                  90                  95      
Gln Tyr Lys Ile Gly Glu Leu Asn Pro Glu Asp Lys Val Ala Pro Thr
            100                 105                 110         
Val Glu Thr Ser Asp Pro Tyr Ala Asp Asp Pro Val Arg His Pro Ala
        115                 120                 125             
Leu Lys Val Asn Ser Gln Arg Pro Phe Asn Ala Glu Pro Pro Pro Glu
    130                 135                 140                 
Leu Leu Thr Glu Asn Tyr Ile Thr Pro Asn Pro Ile Phe Phe Thr Arg
145                 150                 155                 160 
Asn His Leu Pro Val Pro Asn Leu Asp Pro Asp Thr Tyr Arg Leu His
                165                 170                 175     
Val Val Gly Ala Pro Gly Gly Gln Ser Leu Ser Leu Ser Leu Asp Asp
            180                 185                 190         
Leu His Asn Phe Pro Arg Tyr Glu Ile Thr Val Thr Leu Gln Cys Ala
        195                 200                 205             
Gly Asn Arg Arg Ser Glu Met Thr Gln Val Lys Glu Val Lys Gly Leu
    210                 215                 220                 
Glu Trp Arg Thr Gly Ala Ile Ser Thr Ala Arg Trp Ala Gly Ala Arg
225                 230                 235                 240 
Leu Cys Asp Val Leu Ala Gln Ala Gly His Gln Leu Cys Glu Thr Glu
                245                 250                 255     
Ala His Val Cys Phe Glu Gly Leu Asp Ser Asp Pro Thr Gly Thr Ala
            260                 265                 270         
Tyr Gly Ala Ser Ile Pro Leu Ala Arg Ala Met Asp Pro Glu Ala Glu
        275                 280                 285             
Val Leu Leu Ala Tyr Glu Met Asn Gly Gln Pro Leu Pro Arg Asp His
    290                 295                 300                 
Gly Phe Pro Val Arg Val Val Val Pro Gly Val Val Gly Ala Arg His
305                 310                 315                 320 
Val Lys Trp Leu Gly Arg Val Ser Val Gln Pro Glu Glu Ser Tyr Ser
                325                 330                 335     
His Trp Gln Arg Arg Asp Tyr Lys Gly Phe Ser Pro Ser Val Asp Trp
            340                 345                 350         
Glu Thr Val Asp Phe Asp Ser Ala Pro Ser Ile Gln Glu Leu Pro Val
        355                 360                 365             
Gln Ser Ala Ile Thr Glu Pro Arg Asp Gly Glu Thr Val Glu Ser Gly
    370                 375                 380                 
Glu Val Thr Ile Lys Gly Tyr Ala Trp Ser Gly Gly Gly Arg Ala Val
385                 390                 395                 400 
Ile Arg Val Asp Val Ser Leu Asp Gly Gly Leu Thr Trp Gln Val Ala
                405                 410                 415     
Lys Leu Asp Gly Glu Glu Gln Arg Pro Arg Lys Ala Trp Ala Trp Arg
            420                 425                 430         
Leu Trp Gln Leu Lys Ala Pro Val Pro Ala Gly Gln Lys Glu Leu Asn
        435                 440                 445             
Ile Val Cys Lys Ala Val Asp Asp Gly Tyr Asn Val Gln Pro Asp Thr
    450                 455                 460                 
Val Ala Pro Ile Trp Asn Leu Arg Gly Val Leu Ser Asn Ala Trp His
465                 470                 475                 480 
Arg Val His Val Tyr Val Ser Pro
                485             


<210> 562
<211> 2273
<212> PRT
<213> Homo sapiens

<400> 562
Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr
 1               5                  10                  15      
Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro
            20                  25                  30          
Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu
        35                  40                  45              
Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala
    50                  55                  60                  
Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro
65                  70                  75                  80  
Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn
                85                  90                  95      
Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu
            100                 105                 110         
Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu
        115                 120                 125             
Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu
    130                 135                 140                 
Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu
145                 150                 155                 160 
Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser
                165                 170                 175     
Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala
            180                 185                 190         
His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala
        195                 200                 205             
Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr
    210                 215                 220                 
Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile
225                 230                 235                 240 
Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val
                245                 250                 255     
Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser
            260                 265                 270         
Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile
        275                 280                 285             
His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met
    290                 295                 300                 
Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser
305                 310                 315                 320 
Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser
                325                 330                 335     
Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp
            340                 345                 350         
Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser
        355                 360                 365             
Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys
    370                 375                 380                 
Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr
385                 390                 395                 400 
Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser
                405                 410                 415     
Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu
            420                 425                 430         
Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met
        435                 440                 445             
Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu
    450                 455                 460                 
Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn
465                 470                 475                 480 
Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn
                485                 490                 495     
Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu
            500                 505                 510         
Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr
        515                 520                 525             
Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu
    530                 535                 540                 
Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr
545                 550                 555                 560 
Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp
                565                 570                 575     
Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly
            580                 585                 590         
Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe
        595                 600                 605             
Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val
    610                 615                 620                 
Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro
625                 630                 635                 640 
Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro
                645                 650                 655     
Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys
            660                 665                 670         
Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn
        675                 680                 685             
Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser
    690                 695                 700                 
Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met
705                 710                 715                 720 
His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe
                725                 730                 735     
Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser
            740                 745                 750         
Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile
        755                 760                 765             
Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp
    770                 775                 780                 
Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val
785                 790                 795                 800 
Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly
                805                 810                 815     
Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp
            820                 825                 830         
Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala
        835                 840                 845             
Cys Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp
    850                 855                 860                 
Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp
865                 870                 875                 880 
Leu Ser Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys
                885                 890                 895     
Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly
            900                 905                 910         
Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly
        915                 920                 925             
Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro
    930                 935                 940                 
Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala
945                 950                 955                 960 
Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu
                965                 970                 975     
Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg
            980                 985                 990         
Asp Ile Glu Thr Ser Leu Asp Ala Val Arg Gln Ser Leu Gly Met Cys
        995                 1000                1005            
Pro Gln His Asn Ile Leu Phe His His Leu Thr Val Ala Glu His Met
    1010                1015                1020                
Leu Phe Tyr Ala Gln Leu Lys Gly Lys Ser Gln Glu Glu Ala Gln Leu
1025                1030                1035                1040
Glu Met Glu Ala Met Leu Glu Asp Thr Gly Leu His His Lys Arg Asn
                1045                1050                1055    
Glu Glu Ala Gln Asp Leu Ser Gly Gly Met Gln Arg Lys Leu Ser Val
            1060                1065                1070        
Ala Ile Ala Phe Val Gly Asp Ala Lys Val Val Ile Leu Asp Glu Pro
        1075                1080                1085            
Thr Ser Gly Val Asp Pro Tyr Ser Arg Arg Ser Ile Trp Asp Leu Leu
    1090                1095                1100                
Leu Lys Tyr Arg Ser Gly Arg Thr Ile Ile Met Pro Thr His His Met
1105                1110                1115                1120
Asp Glu Ala Asp His Gln Gly Asp Arg Ile Ala Ile Ile Ala Gln Gly
                1125                1130                1135    
Arg Leu Tyr Cys Ser Gly Thr Pro Leu Phe Leu Lys Asn Cys Phe Gly
            1140                1145                1150        
Thr Gly Leu Tyr Leu Thr Leu Val Arg Lys Met Lys Asn Ile Gln Ser
        1155                1160                1165            
Gln Arg Lys Gly Ser Glu Gly Thr Cys Ser Cys Ser Ser Lys Gly Phe
    1170                1175                1180                
Ser Thr Thr Cys Pro Ala His Val Asp Asp Leu Thr Pro Glu Gln Val
1185                1190                1195                1200
Leu Asp Gly Asp Val Asn Glu Leu Met Asp Val Val Leu His His Val
                1205                1210                1215    
Pro Glu Ala Lys Leu Val Glu Cys Ile Gly Gln Glu Leu Ile Phe Leu
            1220                1225                1230        
Leu Pro Asn Lys Asn Phe Lys His Arg Ala Tyr Ala Ser Leu Phe Arg
        1235                1240                1245            
Glu Leu Glu Glu Thr Leu Ala Asp Leu Gly Leu Ser Ser Phe Gly Ile
    1250                1255                1260                
Ser Asp Thr Pro Leu Glu Glu Ile Phe Leu Lys Val Thr Glu Asp Ser
1265                1270                1275                1280
Asp Ser Gly Pro Leu Phe Ala Gly Gly Ala Gln Gln Lys Arg Glu Asn
                1285                1290                1295    
Val Asn Pro Arg His Pro Cys Leu Gly Pro Arg Glu Lys Ala Gly Gln
            1300                1305                1310        
Thr Pro Gln Asp Ser Asn Val Cys Ser Pro Gly Ala Pro Ala Ala His
        1315                1320                1325            
Pro Glu Gly Gln Pro Pro Pro Glu Pro Glu Cys Pro Gly Pro Gln Leu
    1330                1335                1340                
Asn Thr Gly Thr Gln Leu Val Leu Gln His Val Gln Ala Leu Leu Val
1345                1350                1355                1360
Lys Arg Phe Gln His Thr Ile Arg Ser His Lys Asp Phe Leu Ala Gln
                1365                1370                1375    
Ile Val Leu Pro Ala Thr Phe Val Phe Leu Ala Leu Met Leu Ser Ile
            1380                1385                1390        
Val Ile Leu Pro Phe Gly Glu Tyr Pro Ala Leu Thr Leu His Pro Trp
        1395                1400                1405            
Ile Tyr Gly Gln Gln Tyr Thr Phe Phe Ser Met Asp Glu Pro Gly Ser
    1410                1415                1420                
Glu Gln Phe Thr Val Leu Ala Asp Val Leu Leu Asn Lys Pro Gly Phe
1425                1430                1435                1440
Gly Asn Arg Cys Leu Lys Glu Gly Trp Leu Pro Glu Tyr Pro Cys Gly
                1445                1450                1455    
Asn Ser Thr Pro Trp Lys Thr Pro Ser Val Ser Pro Asn Ile Thr Gln
            1460                1465                1470        
Leu Phe Gln Lys Gln Lys Trp Thr Gln Val Asn Pro Ser Pro Ser Cys
        1475                1480                1485            
Arg Cys Ser Thr Arg Glu Lys Leu Thr Met Leu Pro Glu Cys Pro Glu
    1490                1495                1500                
Gly Ala Gly Gly Leu Pro Pro Pro Gln Arg Thr Gln Arg Ser Thr Glu
1505                1510                1515                1520
Ile Leu Gln Asp Leu Thr Asp Arg Asn Ile Ser Asp Phe Leu Val Lys
                1525                1530                1535    
Thr Tyr Pro Ala Leu Ile Arg Ser Ser Leu Lys Ser Lys Phe Trp Val
            1540                1545                1550        
Asn Glu Gln Arg Tyr Gly Gly Ile Ser Ile Gly Gly Lys Leu Pro Val
        1555                1560                1565            
Val Pro Ile Thr Gly Glu Ala Leu Val Gly Phe Leu Ser Asp Leu Gly
    1570                1575                1580                
Arg Ile Met Asn Val Ser Gly Gly Pro Ile Thr Arg Glu Ala Ser Lys
1585                1590                1595                1600
Glu Ile Pro Asp Phe Leu Lys His Leu Glu Thr Glu Asp Asn Ile Lys
                1605                1610                1615    
Val Trp Phe Asn Asn Lys Gly Trp His Ala Leu Val Ser Phe Leu Asn
            1620                1625                1630        
Val Ala His Asn Ala Ile Leu Arg Ala Ser Leu Pro Lys Asp Arg Ser
        1635                1640                1645            
Pro Glu Glu Tyr Gly Ile Thr Val Ile Ser Gln Pro Leu Asn Leu Thr
    1650                1655                1660                
Lys Glu Gln Leu Ser Glu Ile Thr Val Leu Thr Thr Ser Val Asp Ala
1665                1670                1675                1680
Val Val Ala Ile Cys Val Ile Phe Ser Met Ser Phe Val Pro Ala Ser
                1685                1690                1695    
Phe Val Leu Tyr Leu Ile Gln Glu Arg Val Asn Lys Ser Lys His Leu
            1700                1705                1710        
Gln Phe Ile Ser Gly Val Ser Pro Thr Thr Tyr Trp Val Thr Asn Phe
        1715                1720                1725            
Leu Trp Asp Ile Met Asn Tyr Ser Val Ser Ala Gly Leu Val Val Gly
    1730                1735                1740                
Ile Phe Ile Gly Phe Gln Lys Lys Ala Tyr Thr Ser Pro Glu Asn Leu
1745                1750                1755                1760
Pro Ala Leu Val Ala Leu Leu Leu Leu Tyr Gly Trp Ala Val Ile Pro
                1765                1770                1775    
Met Met Tyr Pro Ala Ser Phe Leu Phe Asp Val Pro Ser Thr Ala Tyr
            1780                1785                1790        
Val Ala Leu Ser Cys Ala Asn Leu Phe Ile Gly Ile Asn Ser Ser Ala
        1795                1800                1805            
Ile Thr Phe Ile Leu Glu Leu Phe Asp Asn Asn Arg Thr Leu Leu Arg
    1810                1815                1820                
Phe Asn Ala Val Leu Arg Lys Leu Leu Ile Val Phe Pro His Phe Cys
1825                1830                1835                1840
Leu Gly Arg Gly Leu Ile Asp Leu Ala Leu Ser Gln Ala Val Thr Asp
                1845                1850                1855    
Val Tyr Ala Arg Phe Gly Glu Glu His Ser Ala Asn Pro Phe His Trp
            1860                1865                1870        
Asp Leu Ile Gly Lys Asn Leu Phe Ala Met Val Val Glu Gly Val Val
        1875                1880                1885            
Tyr Phe Leu Leu Thr Leu Leu Val Gln Arg His Phe Phe Leu Ser Gln
    1890                1895                1900                
Trp Ile Ala Glu Pro Thr Lys Glu Pro Ile Val Asp Glu Asp Asp Asp
1905                1910                1915                1920
Val Ala Glu Glu Arg Gln Arg Ile Ile Thr Gly Gly Asn Lys Thr Asp
                1925                1930                1935    
Ile Leu Arg Leu His Glu Leu Thr Lys Ile Tyr Leu Gly Thr Ser Ser
            1940                1945                1950        
Pro Ala Val Asp Arg Leu Cys Val Gly Val Arg Pro Gly Glu Cys Phe
        1955                1960                1965            
Gly Leu Leu Gly Val Asn Gly Ala Gly Lys Thr Thr Thr Phe Lys Met
    1970                1975                1980                
Leu Thr Gly Asp Thr Thr Val Thr Ser Gly Asp Ala Thr Val Ala Gly
1985                1990                1995                2000
Lys Ser Ile Leu Thr Asn Ile Ser Glu Val His Gln Asn Met Gly Tyr
                2005                2010                2015    
Cys Pro Gln Phe Asp Ala Ile Asp Glu Leu Leu Thr Gly Arg Glu His
            2020                2025                2030        
Leu Tyr Leu Tyr Ala Arg Leu Arg Gly Val Pro Ala Glu Glu Ile Glu
        2035                2040                2045            
Lys Val Ala Asn Trp Ser Ile Lys Ser Leu Gly Leu Thr Val Tyr Ala
    2050                2055                2060                
Asp Cys Leu Ala Gly Thr Tyr Ser Gly Gly Asn Lys Arg Lys Leu Ser
2065                2070                2075                2080
Thr Ala Ile Ala Leu Ile Gly Cys Pro Pro Leu Val Leu Leu Asp Glu
                2085                2090                2095    
Pro Thr Thr Gly Met Asp Pro Gln Ala Arg Arg Met Leu Trp Asn Val
            2100                2105                2110        
Ile Val Ser Ile Ile Arg Lys Gly Arg Ala Val Val Leu Thr Ser His
        2115                2120                2125            
Ser Met Glu Glu Cys Glu Ala Leu Cys Thr Arg Leu Ala Ile Met Val
    2130                2135                2140                
Lys Gly Ala Phe Arg Cys Met Gly Thr Ile Gln His Leu Lys Ser Lys
2145                2150                2155                2160
Phe Gly Asp Gly Tyr Ile Val Thr Met Lys Ile Lys Ser Pro Lys Asp
                2165                2170                2175    
Asp Leu Leu Pro Asp Leu Asn Pro Val Glu Gln Phe Phe Gln Gly Asn
            2180                2185                2190        
Phe Pro Gly Ser Val Gln Arg Glu Arg His Tyr Asn Met Leu Gln Phe
        2195                2200                2205            
Gln Val Ser Ser Ser Ser Leu Ala Arg Ile Phe Gln Leu Leu Leu Ser
    2210                2215                2220                
His Lys Asp Ser Leu Leu Ile Glu Glu Tyr Ser Val Thr Gln Thr Thr
2225                2230                2235                2240
Leu Asp Gln Val Phe Val Asn Phe Ala Lys Gln Gln Thr Glu Ser His
                2245                2250                2255    
Asp Leu Pro Leu His Pro Arg Ala Ala Gly Ala Ser Arg Gln Ala Gln
            2260                2265                2270        
Asp
    


<210> 563
<211> 1437
<212> PRT
<213> Homo sapiens

<400> 563
Met Lys Asp Ile Asp Ile Gly Lys Glu Tyr Ile Ile Pro Ser Pro Gly
 1               5                  10                  15      
Tyr Arg Ser Val Arg Glu Arg Thr Ser Thr Ser Gly Thr His Arg Asp
            20                  25                  30          
Arg Glu Asp Ser Lys Phe Arg Arg Thr Arg Pro Leu Glu Cys Gln Asp
        35                  40                  45              
Ala Leu Glu Thr Ala Ala Arg Ala Glu Gly Leu Ser Leu Asp Ala Ser
    50                  55                  60                  
Met His Ser Gln Leu Arg Ile Leu Asp Glu Glu His Pro Lys Gly Lys
65                  70                  75                  80  
Tyr His His Gly Leu Ser Ala Leu Lys Pro Ile Arg Thr Thr Ser Lys
                85                  90                  95      
His Gln His Pro Val Asp Asn Ala Gly Leu Phe Ser Cys Met Thr Phe
            100                 105                 110         
Ser Trp Leu Ser Ser Leu Ala Arg Val Ala His Lys Lys Gly Glu Leu
        115                 120                 125             
Ser Met Glu Asp Val Trp Ser Leu Ser Lys His Glu Ser Ser Asp Val
    130                 135                 140                 
Asn Cys Arg Arg Leu Glu Arg Leu Trp Gln Glu Glu Leu Asn Glu Val
145                 150                 155                 160 
Gly Pro Asp Ala Ala Ser Leu Arg Arg Val Val Trp Ile Phe Cys Pro
                165                 170                 175     
Thr Arg Leu Ile Leu Ser Ile Val Cys Leu Met Ile Thr Gln Leu Ala
            180                 185                 190         
Gly Phe Ser Gly Pro Ala Phe Met Val Lys His Leu Leu Glu Tyr Thr
        195                 200                 205             
Gln Ala Thr Glu Ser Asn Leu Gln Tyr Ser Leu Leu Leu Val Leu Gly
    210                 215                 220                 
Leu Leu Leu Thr Glu Ile Val Arg Ser Trp Ser Leu Ala Leu Thr Trp
225                 230                 235                 240 
Ala Leu Asn Tyr Arg Thr Gly Val Arg Leu Arg Gly Ala Ile Leu Thr
                245                 250                 255     
Met Ala Phe Lys Lys Ile Leu Lys Leu Lys Asn Ile Lys Glu Lys Ser
            260                 265                 270         
Leu Gly Glu Leu Ile Asn Ile Cys Ser Asn Asp Gly Gln Arg Met Phe
        275                 280                 285             
Glu Ala Ala Ala Val Gly Ser Leu Leu Ala Gly Gly Pro Val Val Ala
    290                 295                 300                 
Ile Leu Gly Met Ile Tyr Asn Val Ile Ile Leu Gly Pro Thr Gly Phe
305                 310                 315                 320 
Leu Gly Ser Ala Val Phe Ile Leu Phe Tyr Pro Ala Met Met Phe Ala
                325                 330                 335     
Ser Arg Leu Thr Ala Tyr Phe Arg Arg Lys Cys Val Ala Ala Thr Asp
            340                 345                 350         
Glu Arg Val Gln Lys Met Asn Glu Val Leu Thr Tyr Ile Lys Phe Ile
        355                 360                 365             
Lys Met Tyr Ala Trp Val Lys Ala Phe Ser Gln Ser Val Gln Lys Ile
    370                 375                 380                 
Arg Glu Glu Glu Arg Arg Ile Leu Glu Lys Ala Gly Tyr Phe Gln Ser
385                 390                 395                 400 
Ile Thr Val Gly Val Ala Pro Ile Val Val Val Ile Ala Ser Val Val
                405                 410                 415     
Thr Phe Ser Val His Met Thr Leu Gly Phe Asp Leu Thr Ala Ala Gln
            420                 425                 430         
Ala Phe Thr Val Val Thr Val Phe Asn Ser Met Thr Phe Ala Leu Lys
        435                 440                 445             
Val Thr Pro Phe Ser Val Lys Ser Leu Ser Glu Ala Ser Val Ala Val
    450                 455                 460                 
Asp Arg Phe Lys Ser Leu Phe Leu Met Glu Glu Val His Met Ile Lys
465                 470                 475                 480 
Asn Lys Pro Ala Ser Pro His Ile Lys Ile Glu Met Lys Asn Ala Thr
                485                 490                 495     
Leu Ala Trp Asp Ser Ser His Ser Ser Ile Gln Asn Ser Pro Lys Leu
            500                 505                 510         
Thr Pro Lys Met Lys Lys Asp Lys Arg Ala Ser Arg Gly Lys Lys Glu
        515                 520                 525             
Lys Val Arg Gln Leu Gln Arg Thr Glu His Gln Ala Val Leu Ala Glu
    530                 535                 540                 
Gln Lys Gly His Leu Leu Leu Asp Ser Asp Glu Arg Pro Ser Pro Glu
545                 550                 555                 560 
Glu Glu Glu Gly Lys His Ile His Leu Gly His Leu Arg Leu Gln Arg
                565                 570                 575     
Thr Leu His Ser Ile Asp Leu Glu Ile Gln Glu Gly Lys Leu Val Gly
            580                 585                 590         
Ile Cys Gly Ser Val Gly Ser Gly Lys Thr Ser Leu Ile Ser Ala Ile
        595                 600                 605             
Leu Gly Gln Met Thr Leu Leu Glu Gly Ser Ile Ala Ile Ser Gly Thr
    610                 615                 620                 
Phe Ala Tyr Val Ala Gln Gln Ala Trp Ile Leu Asn Ala Thr Leu Arg
625                 630                 635                 640 
Asp Asn Ile Leu Phe Gly Lys Glu Tyr Asp Glu Glu Arg Tyr Asn Ser
                645                 650                 655     
Val Leu Asn Ser Cys Cys Leu Arg Pro Asp Leu Ala Ile Leu Pro Ser
            660                 665                 670         
Ser Asp Leu Thr Glu Ile Gly Glu Arg Gly Ala Asn Leu Ser Gly Gly
        675                 680                 685             
Gln Arg Gln Arg Ile Ser Leu Ala Arg Ala Leu Tyr Ser Asp Arg Ser
    690                 695                 700                 
Ile Tyr Ile Leu Asp Asp Pro Leu Ser Ala Leu Asp Ala His Val Gly
705                 710                 715                 720 
Asn His Ile Phe Asn Ser Ala Ile Arg Lys His Leu Lys Ser Lys Thr
                725                 730                 735     
Val Leu Phe Val Thr His Gln Leu Gln Tyr Leu Val Asp Cys Asp Glu
            740                 745                 750         
Val Ile Phe Met Lys Glu Gly Cys Ile Thr Glu Arg Gly Thr His Glu
        755                 760                 765             
Glu Leu Met Asn Leu Asn Gly Asp Tyr Ala Thr Ile Phe Asn Asn Leu
    770                 775                 780                 
Leu Leu Gly Glu Thr Pro Pro Val Glu Ile Asn Ser Lys Lys Glu Thr
785                 790                 795                 800 
Ser Gly Ser Gln Lys Lys Ser Gln Asp Lys Gly Pro Lys Thr Gly Ser
                805                 810                 815     
Val Lys Lys Glu Lys Ala Val Lys Pro Glu Glu Gly Gln Leu Val Gln
            820                 825                 830         
Leu Glu Glu Lys Gly Gln Gly Ser Val Pro Trp Ser Val Tyr Gly Val
        835                 840                 845             
Tyr Ile Gln Ala Ala Gly Gly Pro Leu Ala Phe Leu Val Ile Met Ala
    850                 855                 860                 
Leu Phe Met Leu Asn Val Gly Ser Thr Ala Phe Ser Thr Trp Trp Leu
865                 870                 875                 880 
Ser Tyr Trp Ile Lys Gln Gly Ser Gly Asn Thr Thr Val Thr Arg Gly
                885                 890                 895     
Asn Glu Thr Ser Val Ser Asp Ser Met Lys Asp Asn Pro His Met Gln
            900                 905                 910         
Tyr Tyr Ala Ser Ile Tyr Ala Leu Ser Met Ala Val Met Leu Ile Leu
        915                 920                 925             
Lys Ala Ile Arg Gly Val Val Phe Val Lys Gly Thr Leu Arg Ala Ser
    930                 935                 940                 
Ser Arg Leu His Asp Glu Leu Phe Arg Arg Ile Leu Arg Ser Pro Met
945                 950                 955                 960 
Lys Phe Phe Asp Thr Thr Pro Thr Gly Arg Ile Leu Asn Arg Phe Ser
                965                 970                 975     
Lys Asp Met Asp Glu Val Asp Val Arg Leu Pro Phe Gln Ala Glu Met
            980                 985                 990         
Phe Ile Gln Asn Val Ile Leu Val Phe Phe Cys Val Gly Met Ile Ala
        995                 1000                1005            
Gly Val Phe Pro Trp Phe Leu Val Ala Val Gly Pro Leu Val Ile Leu
    1010                1015                1020                
Phe Ser Val Leu His Ile Val Ser Arg Val Leu Ile Arg Glu Leu Lys
1025                1030                1035                1040
Arg Leu Asp Asn Ile Thr Gln Ser Pro Phe Leu Ser His Ile Thr Ser
                1045                1050                1055    
Ser Ile Gln Gly Leu Ala Thr Ile His Ala Tyr Asn Lys Gly Gln Glu
            1060                1065                1070        
Phe Leu His Arg Tyr Gln Glu Leu Leu Asp Asp Asn Gln Ala Pro Phe
        1075                1080                1085            
Phe Leu Phe Thr Cys Ala Met Arg Trp Leu Ala Val Arg Leu Asp Leu
    1090                1095                1100                
Ile Ser Ile Ala Leu Ile Thr Thr Thr Gly Leu Met Ile Val Leu Met
1105                1110                1115                1120
His Gly Gln Ile Pro Pro Ala Tyr Ala Gly Leu Ala Ile Ser Tyr Ala
                1125                1130                1135    
Val Gln Leu Thr Gly Leu Phe Gln Phe Thr Val Arg Leu Ala Ser Glu
            1140                1145                1150        
Thr Glu Ala Arg Phe Thr Ser Val Glu Arg Ile Asn His Tyr Ile Lys
        1155                1160                1165            
Thr Leu Ser Leu Glu Ala Pro Ala Arg Ile Lys Asn Lys Ala Pro Ser
    1170                1175                1180                
Pro Asp Trp Pro Gln Glu Gly Glu Val Thr Phe Glu Asn Ala Glu Met
1185                1190                1195                1200
Arg Tyr Arg Glu Asn Leu Pro Leu Val Leu Lys Lys Val Ser Phe Thr
                1205                1210                1215    
Ile Lys Pro Lys Glu Lys Ile Gly Ile Val Gly Arg Thr Gly Ser Gly
            1220                1225                1230        
Lys Ser Ser Leu Gly Met Ala Leu Phe Arg Leu Val Glu Leu Ser Gly
        1235                1240                1245            
Gly Cys Ile Lys Ile Asp Gly Val Arg Ile Ser Asp Ile Gly Leu Ala
    1250                1255                1260                
Asp Leu Arg Ser Lys Leu Ser Ile Ile Pro Gln Glu Pro Val Leu Phe
1265                1270                1275                1280
Ser Gly Thr Val Arg Ser Asn Leu Asp Pro Phe Asn Gln Tyr Thr Glu
                1285                1290                1295    
Asp Gln Ile Trp Asp Ala Leu Glu Arg Thr His Met Lys Glu Cys Ile
            1300                1305                1310        
Ala Gln Leu Pro Leu Lys Leu Glu Ser Glu Val Met Glu Asn Gly Asp
        1315                1320                1325            
Asn Phe Ser Val Gly Glu Arg Gln Leu Leu Cys Ile Ala Arg Ala Leu
    1330                1335                1340                
Leu Arg His Cys Lys Ile Leu Ile Leu Asp Glu Ala Thr Ala Ala Met
1345                1350                1355                1360
Asp Thr Glu Thr Asp Leu Leu Ile Gln Glu Thr Ile Arg Glu Ala Phe
                1365                1370                1375    
Ala Asp Cys Thr Met Leu Asn Ile Ala His Arg Leu His Thr Val Leu
            1380                1385                1390        
Gly Ser Asp Arg Ile Met Val Leu Ala Gln Gly Gln Val Val Glu Phe
        1395                1400                1405            
Asp Thr Pro Ser Val Leu Leu Ser Asn Asp Ser Ser Arg Phe Tyr Ala
    1410                1415                1420                
Met Phe Ala Ala Ala Glu Asn Lys Val Ala Val Lys Gly
1425                1430                1435        


<210> 564
<211> 348
<212> PRT
<213> Homo sapiens

<400> 564
Arg Lys Leu Ala Tyr Ser Gly Ser Glu Ser Gly Ala Asp Gly Arg Lys
 1               5                  10                  15      
Ala Ala Glu Pro Glu Val Glu Val Glu Val Tyr Arg Arg Asp Ser Lys
            20                  25                  30          
Lys Leu Pro Gly Leu Gly Asp Pro Asp Ile Asp Trp Glu Glu Ser Val
        35                  40                  45              
Cys Leu Asn Leu Ile Leu Gln Lys Leu Asp Tyr Met Val Thr Cys Ala
    50                  55                  60                  
Val Cys Thr Arg Ala Asp Gly Gly Asp Ile His Ile His Lys Lys Lys
65                  70                  75                  80  
Ser Gln Gln Val Phe Ala Ser Pro Ser Lys His Pro Met Asp Ser Lys
                85                  90                  95      
Gly Glu Glu Ser Lys Ile Ser Tyr Pro Asn Ile Phe Phe Met Ile Asp
            100                 105                 110         
Ser Phe Glu Glu Val Phe Ser Asp Met Thr Val Gly Glu Gly Glu Met
        115                 120                 125             
Val Cys Val Glu Leu Val Ala Ser Asp Lys Thr Asn Thr Phe Gln Gly
    130                 135                 140                 
Val Ile Phe Gln Gly Ser Ile Arg Tyr Glu Ala Leu Lys Lys Val Tyr
145                 150                 155                 160 
Asp Asn Arg Val Ser Val Ala Ala Arg Met Ala Gln Lys Met Ser Phe
                165                 170                 175     
Gly Phe Tyr Lys Tyr Ser Asn Met Glu Phe Val Arg Met Lys Gly Pro
            180                 185                 190         
Gln Gly Lys Gly His Ala Glu Met Ala Val Ser Arg Val Ser Thr Gly
        195                 200                 205             
Asp Thr Ser Pro Cys Gly Thr Glu Glu Asp Ser Ser Pro Ala Ser Pro
    210                 215                 220                 
Met His Glu Arg Val Thr Ser Phe Ser Thr Pro Pro Thr Pro Glu Arg
225                 230                 235                 240 
Asn Asn Arg Pro Ala Phe Phe Ser Pro Ser Leu Lys Arg Lys Val Pro
                245                 250                 255     
Arg Asn Arg Ile Ala Glu Met Lys Lys Ser His Ser Ala Asn Asp Ser
            260                 265                 270         
Glu Glu Phe Phe Arg Glu Asp Asp Gly Gly Ala Asp Leu His Asn Ala
        275                 280                 285             
Thr Asn Leu Arg Ser Arg Ser Leu Ser Gly Thr Gly Arg Ser Leu Val
    290                 295                 300                 
Gly Ser Trp Leu Lys Leu Asn Arg Ala Asp Gly Asn Phe Leu Leu Tyr
305                 310                 315                 320 
Ala His Leu Thr Tyr Val Thr Leu Pro Leu His Arg Ile Leu Thr Asp
                325                 330                 335     
Ile Leu Glu Val Arg Gln Lys Pro Ile Leu Met Thr
            340                 345             


<210> 565
<211> 891
<212> PRT
<213> Homo sapiens

<400> 565
Ala Arg Met Asn Cys Glu Arg Glu Leu His Lys Leu Glu Gly Asn Leu
 1               5                  10                  15      
Lys Leu Asn Arg Glu Ser Met Glu Asn Leu Glu Ser Ser Gln Arg His
            20                  25                  30          
Leu Ala Glu Glu Leu Arg Lys Lys Glu Leu Glu Leu Ser Gln Met Asn
        35                  40                  45              
Ser Lys Val Glu Asn Glu Lys Gly Leu Val Ala Gln Leu Gln Lys Thr
    50                  55                  60                  
Val Lys Glu Leu Gln Thr Gln Ile Lys Asp Leu Lys Glu Lys Leu Glu
65                  70                  75                  80  
Ala Glu Arg Thr Thr Arg Ala Lys Met Glu Arg Glu Arg Ala Asp Leu
                85                  90                  95      
Thr Gln Asp Leu Ala Asp Leu Asn Glu Arg Leu Glu Glu Val Gly Gly
            100                 105                 110         
Ser Ser Leu Ala Gln Leu Glu Ile Thr Lys Lys Gln Glu Thr Lys Phe
        115                 120                 125             
Gln Lys Leu His Arg Asp Met Glu Glu Ala Thr Leu His Phe Glu Thr
    130                 135                 140                 
Thr Ser Ala Ser Leu Lys Lys Arg His Ala Asp Ser Leu Ala Glu Leu
145                 150                 155                 160 
Glu Gly Gln Val Glu Asn Leu Gln Gln Val Lys Gln Lys Leu Glu Lys
                165                 170                 175     
Asp Lys Ser Asp Leu Gln Leu Glu Val Asp Asp Leu Leu Thr Arg Val
            180                 185                 190         
Glu Gln Met Thr Arg Ala Lys Ala Asn Ala Glu Lys Leu Cys Thr Leu
        195                 200                 205             
Tyr Glu Glu Arg Leu His Glu Ala Thr Ala Lys Leu Asp Lys Val Thr
    210                 215                 220                 
Gln Leu Ala Asn Asp Leu Ala Ala Gln Lys Thr Lys Leu Trp Ser Glu
225                 230                 235                 240 
Ser Gly Glu Phe Leu Arg Arg Leu Glu Glu Lys Glu Ala Leu Ile Asn
                245                 250                 255     
Gln Leu Ser Arg Glu Lys Ser Asn Phe Thr Arg Gln Ile Glu Asp Leu
            260                 265                 270         
Arg Gly Gln Leu Glu Lys Glu Thr Lys Ser Gln Ser Ala Leu Ala His
        275                 280                 285             
Ala Leu Gln Lys Ala Gln Arg Asp Cys Asp Leu Leu Arg Glu Gln Tyr
    290                 295                 300                 
Glu Glu Glu Gln Glu Val Lys Ala Glu Leu His Arg Thr Leu Ser Lys
305                 310                 315                 320 
Val Asn Ala Glu Met Val Gln Trp Arg Met Lys Tyr Glu Asn Asn Val
                325                 330                 335     
Ile Gln Arg Thr Glu Asp Leu Glu Asp Ala Lys Lys Glu Leu Ala Ile
            340                 345                 350         
Arg Leu Gln Glu Ala Ala Glu Ala Met Gly Val Ala Asn Ala Arg Asn
        355                 360                 365             
Ala Ser Leu Glu Arg Ala Arg His Gln Leu Gln Leu Glu Leu Gly Asp
    370                 375                 380                 
Ala Leu Ser Asp Leu Gly Lys Val Arg Ser Ala Ala Ala Arg Leu Asp
385                 390                 395                 400 
Gln Lys Gln Leu Gln Ser Gly Lys Ala Leu Ala Asp Trp Lys Gln Lys
                405                 410                 415     
His Glu Glu Ser Gln Ala Leu Leu Asp Ala Ser Gln Lys Glu Val Gln
            420                 425                 430         
Ala Leu Ser Thr Glu Leu Leu Lys Leu Lys Asn Thr Tyr Glu Glu Ser
        435                 440                 445             
Ile Val Gly Gln Glu Thr Leu Arg Arg Glu Asn Lys Asn Leu Gln Glu
    450                 455                 460                 
Glu Ile Ser Asn Leu Thr Asn Gln Val Arg Glu Gly Thr Lys Asn Leu
465                 470                 475                 480 
Thr Glu Met Glu Lys Val Lys Lys Leu Ile Glu Glu Glu Lys Thr Glu
                485                 490                 495     
Val Gln Val Thr Leu Glu Glu Thr Glu Gly Ala Leu Glu Arg Asn Glu
            500                 505                 510         
Ser Lys Ile Leu His Phe Gln Leu Glu Leu Leu Glu Ala Lys Ala Glu
        515                 520                 525             
Leu Glu Arg Lys Leu Ser Glu Lys Asp Glu Glu Ile Glu Asn Phe Arg
    530                 535                 540                 
Arg Lys Gln Gln Cys Thr Ile Asp Ser Leu Gln Ser Ser Leu Asp Ser
545                 550                 555                 560 
Glu Ala Lys Ser Arg Ile Glu Val Thr Arg Leu Lys Lys Lys Met Glu
                565                 570                 575     
Glu Asp Leu Asn Glu Met Glu Leu Gln Leu Ser Cys Ala Asn Arg Gln
            580                 585                 590         
Val Ser Glu Ala Thr Lys Ser Leu Gly Gln Leu Gln Ile Gln Ile Lys
        595                 600                 605             
Asp Leu Gln Met Gln Leu Asp Asp Ser Thr Gln Leu Asn Ser Asp Leu
    610                 615                 620                 
Lys Glu Gln Val Ala Val Ala Glu Arg Arg Asn Ser Leu Leu Gln Ser
625                 630                 635                 640 
Glu Leu Glu Asp Leu Arg Ser Leu Gln Glu Gln Thr Glu Arg Gly Arg
                645                 650                 655     
Arg Leu Ser Glu Glu Glu Leu Leu Glu Ala Thr Glu Arg Ile Asn Leu
            660                 665                 670         
Phe Tyr Thr Gln Asn Thr Ser Leu Leu Ser Gln Lys Lys Lys Leu Glu
        675                 680                 685             
Ala Asp Val Ala Arg Met Gln Lys Glu Ala Glu Glu Val Val Gln Glu
    690                 695                 700                 
Cys Gln Asn Ala Glu Glu Lys Ala Lys Lys Ala Ala Ile Glu Ala Ala
705                 710                 715                 720 
Asn Leu Ser Glu Glu Leu Lys Lys Lys Gln Asp Thr Ile Ala His Leu
                725                 730                 735     
Glu Arg Thr Arg Glu Asn Met Glu Gln Thr Ile Thr Asp Leu Gln Lys
            740                 745                 750         
Arg Leu Ala Glu Ala Glu Gln Met Ala Leu Met Gly Ser Arg Lys Gln
        755                 760                 765             
Ile Gln Lys Leu Glu Ser Arg Val Arg Glu Leu Glu Gly Glu Leu Glu
    770                 775                 780                 
Gly Glu Ile Arg Arg Ser Ala Glu Ala Gln Arg Gly Ala Arg Arg Leu
785                 790                 795                 800 
Glu Arg Cys Ile Lys Glu Leu Thr Tyr Gln Ala Glu Glu Asp Lys Lys
                805                 810                 815     
Asn Leu Ser Arg Met Gln Thr Gln Met Asp Lys Leu Gln Leu Lys Val
            820                 825                 830         
Gln Asn Tyr Lys Gln Gln Val Glu Val Ala Glu Thr Gln Ala Asn Gln
        835                 840                 845             
Tyr Leu Ser Lys Tyr Lys Lys Gln Gln His Glu Leu Asn Glu Val Lys
    850                 855                 860                 
Glu Arg Ala Glu Val Ala Glu Ser Gln Val Asn Lys Leu Lys Ile Lys
865                 870                 875                 880 
Ala Arg Glu Phe Gly Lys Lys Val Gln Glu Glu
                885                 890     


<210> 566
<211> 609
<212> PRT
<213> Homo sapiens

<400> 566
Met Phe Arg Cys Gly Gly Leu Ala Ala Gly Ala Leu Lys Gln Lys Leu
 1               5                  10                  15      
Val Pro Leu Val Arg Thr Val Cys Val Arg Ser Pro Arg Gln Arg Asn
            20                  25                  30          
Arg Leu Pro Val Val Gln Ser His His Leu Gly Ser Pro Ser Arg Ser
        35                  40                  45              
Leu Ala Ser Thr Gly Ala Ser Gly Lys Asp Gly Ser Asn Leu Val Tyr
    50                  55                  60                  
Phe Leu Ile Val Gly Ala Thr Val Thr Gly Ala Gly Val Tyr Tyr Ala
65                  70                  75                  80  
Tyr Lys Thr Met Lys Glu Asp Glu Lys Arg Tyr Asn Glu Arg Ile Ser
                85                  90                  95      
Gly Leu Gly Leu Thr Pro Glu Gln Lys Gln Lys Lys Ala Ala Leu Ser
            100                 105                 110         
Ala Ser Glu Gly Glu Glu Val Pro Gln Asp Lys Ala Pro Ser His Val
        115                 120                 125             
Pro Phe Leu Leu Ile Gly Gly Gly Thr Ala Ala Phe Ala Ala Ala Arg
    130                 135                 140                 
Ser Ile Arg Ala Arg Asp Pro Gly Ala Arg Val Leu Ile Val Ser Glu
145                 150                 155                 160 
Asp Pro Glu Leu Pro Tyr Met Arg Pro Pro Leu Ser Lys Glu Leu Trp
                165                 170                 175     
Phe Ser Asp Asp Pro Asn Val Thr Lys Thr Leu Arg Phe Lys Gln Trp
            180                 185                 190         
Asn Gly Lys Glu Arg Ser Ile Tyr Phe Gln Pro Pro Ser Phe Tyr Val
        195                 200                 205             
Ser Ala Gln Asp Leu Pro His Ile Glu Asn Gly Gly Val Ala Val Leu
    210                 215                 220                 
Thr Gly Lys Lys Val Val Gln Leu Asp Val Arg Asp Asn Met Val Lys
225                 230                 235                 240 
Leu Asn Asp Gly Ser Gln Ile Thr Tyr Glu Lys Cys Leu Ile Ala Thr
                245                 250                 255     
Gly Gly Thr Pro Arg Ser Leu Ser Ala Ile Asp Arg Ala Gly Ala Glu
            260                 265                 270         
Val Lys Ser Arg Thr Thr Leu Phe Arg Lys Ile Gly Asp Phe Arg Ser
        275                 280                 285             
Leu Glu Lys Ile Ser Arg Glu Val Lys Ser Ile Thr Ile Ile Gly Gly
    290                 295                 300                 
Gly Phe Leu Gly Ser Glu Leu Ala Cys Ala Leu Gly Arg Lys Ala Arg
305                 310                 315                 320 
Ala Leu Gly Thr Glu Val Ile Gln Leu Phe Pro Glu Lys Gly Asn Met
                325                 330                 335     
Gly Lys Ile Leu Pro Glu Tyr Leu Ser Asn Trp Thr Met Glu Lys Val
            340                 345                 350         
Arg Arg Glu Gly Val Lys Val Met Pro Asn Ala Ile Val Gln Ser Val
        355                 360                 365             
Gly Val Ser Ser Gly Lys Leu Leu Ile Lys Leu Lys Asp Gly Arg Lys
    370                 375                 380                 
Val Glu Thr Asp His Ile Val Ala Ala Val Gly Leu Glu Pro Asn Val
385                 390                 395                 400 
Glu Leu Ala Lys Thr Gly Gly Leu Glu Ile Asp Ser Asp Phe Gly Gly
                405                 410                 415     
Phe Arg Val Asn Ala Glu Leu Gln Ala Arg Ser Asn Ile Trp Val Ala
            420                 425                 430         
Gly Asp Ala Ala Cys Phe Tyr Asp Ile Lys Leu Gly Arg Arg Arg Val
        435                 440                 445             
Glu His His Asp His Ala Val Val Ser Gly Arg Leu Ala Gly Glu Asn
    450                 455                 460                 
Met Thr Gly Ala Ala Lys Pro Tyr Trp His Gln Ser Met Phe Trp Ser
465                 470                 475                 480 
Asp Leu Gly Pro Asp Val Gly Tyr Glu Ala Ile Gly Leu Val Asp Ser
                485                 490                 495     
Ser Leu Pro Thr Val Gly Val Phe Ala Lys Ala Thr Ala Gln Asp Asn
            500                 505                 510         
Pro Lys Ser Ala Thr Glu Gln Ser Gly Thr Gly Ile Arg Ser Glu Ser
        515                 520                 525             
Glu Thr Glu Ser Glu Ala Ser Glu Ile Thr Ile Pro Pro Ser Thr Pro
    530                 535                 540                 
Ala Val Pro Gln Ala Pro Val Gln Gly Glu Asp Tyr Gly Lys Gly Val
545                 550                 555                 560 
Ile Phe Tyr Leu Arg Asp Lys Val Val Val Gly Ile Val Leu Trp Asn
                565                 570                 575     
Ile Phe Asn Arg Met Pro Ile Ala Arg Lys Ile Ile Lys Asp Gly Glu
            580                 585                 590         
Gln His Glu Asp Leu Asn Glu Val Ala Lys Leu Phe Asn Ile His Glu
        595                 600                 605             
Asp
    


<210> 567
<211> 231
<212> PRT
<213> Homo sapiens

<400> 567
Met Leu Lys Asn Pro Tyr Thr Ile Lys Lys Gln Pro Leu His Gln Phe
 1               5                  10                  15      
Val Gln Arg Pro Leu Phe Pro Leu Pro Ala Ala Phe Tyr His Pro Val
            20                  25                  30          
Arg Tyr Met Phe Ile Gln Thr Gln Asp Thr Pro Asn Pro Asn Ser Leu
        35                  40                  45              
Lys Phe Ile Pro Gly Lys Pro Val Leu Glu Thr Arg Thr Met Asp Phe
    50                  55                  60                  
Pro Thr Pro Ala Ala Ala Phe Arg Ser Pro Leu Ala Arg Gln Leu Phe
65                  70                  75                  80  
Arg Ile Glu Gly Val Lys Ser Val Phe Phe Trp Asp Gln Ile Phe Ile
                85                  90                  95      
Thr Val Thr Lys Glu Asn Glu Glu Leu Asp Trp Asn Leu Leu Lys Pro
            100                 105                 110         
Asp Ile Tyr Ala Thr Ile Met Asp Phe Phe Ala Ser Gly Leu Pro Leu
        115                 120                 125             
Val Thr Glu Glu Thr Pro Pro Gly Glu Ala Gly Ser Glu Glu Asp Asp
    130                 135                 140                 
Glu Val Val Ala Met Ile Lys Glu Leu Leu Asp Thr Arg Ile Arg Pro
145                 150                 155                 160 
Thr Val Gln Glu Asp Gly Gly Asp Val Ile Tyr Lys Gly Phe Glu Asp
                165                 170                 175     
Gly Ile Val Gln Leu Lys Leu Gln Gly Ser Cys Thr Ser Cys Pro Ser
            180                 185                 190         
Ser Ile Ile Thr Leu Lys Asn Gly Ile Gln Asn Met Leu Gln Phe Tyr
        195                 200                 205             
Ile Pro Glu Val Glu Gly Val Glu Gln Val Met Asp Asp Glu Ser Asp
    210                 215                 220                 
Glu Lys Glu Ala Asn Ser Pro
225                 230     


<210> 568
<211> 933
<212> PRT
<213> Homo sapiens

<400> 568
Met Arg Ala Leu Ala Val Leu Ser Val Thr Leu Val Met Ala Cys Thr
 1               5                  10                  15      
Glu Ala Phe Phe Pro Phe Ile Ser Arg Gly Lys Glu Leu Leu Trp Gly
            20                  25                  30          
Lys Pro Glu Glu Ser Arg Val Ser Ser Val Leu Glu Glu Ser Lys Arg
        35                  40                  45              
Leu Val Asp Thr Ala Met Tyr Ala Thr Met Gln Arg Asn Leu Lys Lys
    50                  55                  60                  
Arg Gly Ile Leu Ser Gly Ala Gln Leu Leu Ser Phe Ser Lys Leu Pro
65                  70                  75                  80  
Glu Pro Thr Ser Gly Val Ile Ala Arg Ala Ala Glu Ile Met Glu Thr
                85                  90                  95      
Ser Ile Gln Ala Met Lys Arg Lys Val Asn Leu Lys Thr Gln Gln Ser
            100                 105                 110         
Gln His Pro Thr Asp Ala Leu Ser Glu Asp Leu Leu Ser Ile Ile Ala
        115                 120                 125             
Asn Met Ser Gly Cys Leu Pro Tyr Met Leu Pro Pro Lys Cys Pro Asn
    130                 135                 140                 
Thr Cys Leu Ala Asn Lys Tyr Arg Pro Ile Thr Gly Ala Cys Asn Asn
145                 150                 155                 160 
Arg Asp His Pro Arg Trp Gly Ala Ser Asn Thr Ala Leu Ala Arg Trp
                165                 170                 175     
Leu Pro Pro Val Tyr Glu Asp Gly Phe Ser Gln Pro Arg Gly Trp Asn
            180                 185                 190         
Pro Gly Phe Leu Tyr Asn Gly Phe Pro Leu Pro Pro Val Arg Glu Val
        195                 200                 205             
Thr Arg His Val Ile Gln Val Ser Asn Glu Val Val Thr Asp Asp Asp
    210                 215                 220                 
Arg Tyr Ser Asp Leu Leu Met Ala Trp Gly Gln Tyr Ile Asp His Asp
225                 230                 235                 240 
Ile Ala Phe Thr Pro Gln Ser Thr Ser Lys Ala Ala Phe Gly Gly Gly
                245                 250                 255     
Ser Asp Cys Gln Met Thr Cys Glu Asn Gln Asn Pro Cys Phe Pro Ile
            260                 265                 270         
Gln Leu Pro Glu Glu Ala Arg Pro Ala Ala Gly Thr Ala Cys Leu Pro
        275                 280                 285             
Phe Tyr Arg Ser Ser Ala Ala Cys Gly Thr Gly Asp Gln Gly Ala Leu
    290                 295                 300                 
Phe Gly Asn Leu Ser Thr Ala Asn Pro Arg Gln Gln Met Asn Gly Leu
305                 310                 315                 320 
Thr Ser Phe Leu Asp Ala Ser Thr Val Tyr Gly Ser Ser Pro Ala Leu
                325                 330                 335     
Glu Arg Gln Leu Arg Asn Trp Thr Ser Ala Glu Gly Leu Leu Arg Val
            340                 345                 350         
His Gly Arg Leu Arg Asp Ser Gly Arg Ala Tyr Leu Pro Phe Val Pro
        355                 360                 365             
Pro Arg Ala Pro Ala Ala Cys Ala Pro Glu Pro Gly Asn Pro Gly Glu
    370                 375                 380                 
Thr Arg Gly Pro Cys Phe Leu Ala Gly Asp Gly Arg Ala Ser Glu Val
385                 390                 395                 400 
Pro Ser Leu Thr Ala Leu His Thr Leu Trp Leu Arg Glu His Asn Arg
                405                 410                 415     
Leu Ala Ala Ala Leu Lys Ala Leu Asn Ala His Trp Ser Ala Asp Ala
            420                 425                 430         
Val Tyr Gln Glu Ala Arg Lys Val Val Gly Ala Leu His Gln Ile Ile
        435                 440                 445             
Thr Leu Arg Asp Tyr Ile Pro Arg Ile Leu Gly Pro Glu Ala Phe Gln
    450                 455                 460                 
Gln Tyr Val Gly Pro Tyr Glu Gly Tyr Asp Ser Thr Ala Asn Pro Thr
465                 470                 475                 480 
Val Ser Asn Val Phe Ser Thr Ala Ala Phe Arg Phe Gly His Ala Thr
                485                 490                 495     
Ile His Pro Leu Val Arg Arg Leu Asp Ala Ser Phe Gln Glu His Pro
            500                 505                 510         
Asp Leu Pro Gly Leu Trp Leu His Gln Ala Phe Phe Ser Pro Trp Thr
        515                 520                 525             
Leu Leu Arg Gly Gly Gly Leu Asp Pro Leu Ile Arg Gly Leu Leu Ala
    530                 535                 540                 
Arg Pro Ala Lys Leu Gln Val Gln Asp Gln Leu Met Asn Glu Glu Leu
545                 550                 555                 560 
Thr Glu Arg Leu Phe Val Leu Ser Asn Ser Ser Thr Leu Asp Leu Ala
                565                 570                 575     
Ser Ile Asn Leu Gln Arg Gly Arg Asp His Gly Leu Pro Gly Tyr Asn
            580                 585                 590         
Glu Trp Arg Glu Phe Cys Gly Leu Pro Arg Leu Glu Thr Pro Ala Asp
        595                 600                 605             
Leu Ser Thr Ala Ile Ala Ser Arg Ser Val Ala Asp Lys Ile Leu Asp
    610                 615                 620                 
Leu Tyr Lys His Pro Asp Asn Ile Asp Val Trp Leu Gly Gly Leu Ala
625                 630                 635                 640 
Glu Asn Phe Leu Pro Arg Ala Arg Thr Gly Pro Leu Phe Ala Cys Leu
                645                 650                 655     
Ile Gly Lys Gln Met Lys Ala Leu Arg Asp Gly Asp Trp Phe Trp Trp
            660                 665                 670         
Glu Asn Ser His Val Phe Thr Asp Ala Gln Arg Arg Glu Leu Glu Lys
        675                 680                 685             
His Ser Leu Ser Arg Val Ile Cys Asp Asn Thr Gly Leu Thr Arg Val
    690                 695                 700                 
Pro Met Asp Ala Phe Gln Val Gly Lys Phe Pro Glu Asp Phe Glu Ser
705                 710                 715                 720 
Cys Asp Ser Ile Thr Gly Met Asn Leu Glu Ala Trp Arg Glu Thr Phe
                725                 730                 735     
Pro Gln Asp Asp Lys Cys Gly Phe Pro Glu Ser Val Glu Asn Gly Asp
            740                 745                 750         
Phe Val His Cys Glu Glu Ser Gly Arg Arg Val Leu Val Tyr Ser Cys
        755                 760                 765             
Arg His Gly Tyr Glu Leu Gln Gly Arg Glu Gln Leu Thr Cys Thr Gln
    770                 775                 780                 
Glu Gly Trp Asp Phe Gln Pro Pro Leu Cys Lys Asp Val Asn Glu Cys
785                 790                 795                 800 
Ala Asp Gly Ala His Pro Pro Cys His Ala Ser Ala Arg Cys Arg Asn
                805                 810                 815     
Thr Lys Gly Gly Phe Gln Cys Leu Cys Ala Asp Pro Tyr Glu Leu Gly
            820                 825                 830         
Asp Asp Gly Arg Thr Cys Val Asp Ser Gly Arg Leu Pro Arg Val Thr
        835                 840                 845             
Trp Ile Ser Met Ser Leu Ala Ala Leu Leu Ile Gly Gly Phe Ala Gly
    850                 855                 860                 
Leu Thr Ser Thr Val Ile Cys Arg Trp Thr Arg Thr Gly Thr Lys Ser
865                 870                 875                 880 
Thr Leu Pro Ile Ser Glu Thr Gly Gly Gly Thr Pro Glu Leu Arg Cys
                885                 890                 895     
Gly Lys His Gln Ala Val Gly Thr Ser Pro Gln Arg Ala Ala Ala Gln
            900                 905                 910         
Asp Ser Glu Gln Glu Ser Ala Gly Met Glu Gly Arg Asp Thr His Arg
        915                 920                 925             
Leu Pro Arg Ala Leu
    930             


<210> 569
<211> 186
<212> PRT
<213> Homo sapiens

<400> 569
Met Ala Val Ala Arg Ala Gly Val Leu Gly Val Gln Trp Leu Gln Arg
 1               5                  10                  15      
Ala Ser Arg Asn Val Met Pro Leu Gly Ala Arg Thr Ala Ser His Met
            20                  25                  30          
Thr Lys Asp Met Phe Pro Gly Pro Tyr Pro Arg Thr Pro Glu Glu Arg
        35                  40                  45              
Ala Ala Ala Ala Lys Lys Tyr Asn Met Arg Val Glu Asp Tyr Glu Pro
    50                  55                  60                  
Tyr Pro Asp Asp Gly Met Gly Tyr Gly Asp Tyr Pro Lys Leu Pro Asp
65                  70                  75                  80  
Arg Ser Gln His Glu Arg Asp Pro Trp Tyr Ser Trp Asp Gln Pro Gly
                85                  90                  95      
Leu Arg Leu Asn Trp Gly Glu Pro Met His Trp His Leu Asp Met Tyr
            100                 105                 110         
Asn Arg Asn Arg Val Asp Thr Ser Pro Thr Pro Val Ser Trp His Val
        115                 120                 125             
Met Cys Met Gln Leu Phe Gly Phe Leu Ala Phe Met Ile Phe Met Cys
    130                 135                 140                 
Trp Val Gly Asp Val Tyr Pro Val Tyr Gln Pro Val Gly Pro Lys Gln
145                 150                 155                 160 
Tyr Pro Tyr Asn Asn Leu Tyr Leu Glu Arg Ser Gly Asp Pro Ser Lys
                165                 170                 175     
Glu Pro Glu Arg Val Val His Tyr Glu Ile
            180                 185     


<210> 570
<211> 520
<212> PRT
<213> Homo sapiens

<400> 570
Met Gly Lys Pro Ser Ser Met Asp Thr Lys Phe Lys Asp Asp Leu Phe
 1               5                  10                  15      
Arg Lys Tyr Val Gln Phe His Glu Ser Lys Val Asp Thr Thr Thr Ser
            20                  25                  30          
Arg Gln Arg Pro Gly Ser Asp Glu Cys Leu Arg Val Ala Ala Ser Thr
        35                  40                  45              
Leu Leu Ser Leu His Lys Val Asp Pro Phe Tyr Arg Phe Arg Leu Ile
    50                  55                  60                  
Gln Phe Tyr Glu Val Val Glu Ser Ser Leu Arg Ser Leu Ser Ser Ser
65                  70                  75                  80  
Ser Leu Arg Ala Leu His Gly Ala Phe Ser Met Leu Glu Thr Val Gly
                85                  90                  95      
Ile Asn Leu Phe Leu Tyr Pro Trp Lys Lys Glu Phe Arg Ser Ile Lys
            100                 105                 110         
Thr Tyr Thr Gly Pro Phe Val Tyr Tyr Val Lys Ser Thr Leu Leu Glu
        115                 120                 125             
Glu Asp Ile Arg Ala Ile Leu Ser Cys Met Gly Tyr Thr Pro Glu Leu
    130                 135                 140                 
Gly Thr Ala Tyr Lys Leu Arg Glu Leu Val Glu Thr Leu Gln Val Lys
145                 150                 155                 160 
Met Val Ser Phe Glu Leu Phe Leu Ala Lys Val Asp Cys Glu Gln Met
                165                 170                 175     
Leu Glu Ile His Ser Gln Val Lys Asp Lys Gly Tyr Ser Glu Leu Asp
            180                 185                 190         
Ile Val Ser Glu Arg Lys Ser Ser Ala Glu Asp Val Arg Gly Cys Ser
        195                 200                 205             
Asp Ala Leu Arg Arg Arg Ala Glu Gly Arg Glu His Leu Thr Ala Ser
    210                 215                 220                 
Met Ser Arg Val Ala Leu Gln Lys Ser Ala Ser Glu Arg Ala Ala Lys
225                 230                 235                 240 
Asp Tyr Tyr Lys Pro Arg Val Thr Lys Pro Ser Arg Ser Val Asp Ala
                245                 250                 255     
Tyr Asp Ser Tyr Trp Glu Ser Arg Lys Pro Pro Leu Lys Ala Ser Leu
            260                 265                 270         
Ser Leu Arg Lys Glu Pro Val Ala Thr Asp Val Gly Asp Asp Leu Lys
        275                 280                 285             
Asp Glu Ile Ile Arg Pro Ser Pro Ser Leu Leu Thr Met Ala Ser Ser
    290                 295                 300                 
Pro His Gly Ser Pro Asp Val Leu Pro Pro Ala Ser Pro Ser Asn Gly
305                 310                 315                 320 
Pro Ala Leu Leu Arg Gly Thr Tyr Phe Ser Thr Gln Asp Asp Val Asp
                325                 330                 335     
Leu Tyr Thr Asp Ser Glu Pro Arg Ala Thr Tyr Arg Arg Gln Asp Ala
            340                 345                 350         
Leu Arg Pro Asp Val Trp Leu Leu Arg Asn Asp Ala His Ser Leu Tyr
        355                 360                 365             
His Lys Arg Ser Pro Pro Ala Lys Glu Ser Ala Leu Ser Lys Cys Gln
    370                 375                 380                 
Ser Cys Gly Leu Ser Cys Ser Ser Ser Leu Cys Gln Arg Cys Asp Ser
385                 390                 395                 400 
Leu Leu Thr Cys Pro Pro Ala Ser Lys Pro Ser Ala Phe Pro Ser Lys
                405                 410                 415     
Ala Ser Thr His Asp Ser Leu Ala His Gly Ala Ser Leu Arg Glu Lys
            420                 425                 430         
Tyr Pro Gly Gln Thr Gln Gly Leu Asp Arg Leu Pro His Leu His Ser
        435                 440                 445             
Lys Ser Lys Pro Ser Thr Thr Pro Thr Ser Arg Cys Gly Phe Cys Asn
    450                 455                 460                 
Arg Pro Gly Ala Thr Asn Thr Cys Thr Gln Cys Ser Lys Val Ser Cys
465                 470                 475                 480 
Asp Ala Cys Leu Ser Ala Tyr His Tyr Asp Pro Cys Tyr Lys Lys Ser
                485                 490                 495     
Glu Leu His Lys Phe Met Pro Asn Asn Gln Leu Asn Tyr Lys Ser Thr
            500                 505                 510         
Gln Leu Ser His Leu Val Tyr Arg
        515                 520 


<210> 571
<211> 613
<212> PRT
<213> Homo sapiens

<400> 571
Met Phe Arg Cys Gly Gly Leu Ala Ala Gly Ala Leu Lys Gln Lys Leu
 1               5                  10                  15      
Val Pro Leu Val Arg Thr Val Cys Val Arg Ser Pro Arg Gln Arg Asn
            20                  25                  30          
Arg Leu Pro Gly Asn Leu Phe Gln Arg Trp His Val Pro Leu Glu Leu
        35                  40                  45              
Gln Met Thr Arg Gln Met Ala Ser Ser Gly Ala Ser Gly Gly Lys Ile
    50                  55                  60                  
Asp Asn Ser Val Leu Val Leu Ile Val Gly Leu Ser Thr Val Gly Ala
65                  70                  75                  80  
Gly Ala Tyr Ala Tyr Lys Thr Met Lys Glu Asp Glu Lys Arg Tyr Asn
                85                  90                  95      
Glu Arg Ile Ser Gly Leu Gly Leu Thr Pro Glu Gln Lys Gln Lys Lys
            100                 105                 110         
Ala Ala Leu Ser Ala Ser Glu Gly Glu Glu Val Pro Gln Asp Lys Ala
        115                 120                 125             
Pro Ser His Val Pro Phe Leu Leu Ile Gly Gly Gly Thr Ala Ala Phe
    130                 135                 140                 
Ala Ala Ala Arg Ser Ile Arg Ala Arg Asp Pro Gly Ala Arg Val Leu
145                 150                 155                 160 
Ile Val Ser Glu Asp Pro Glu Leu Pro Tyr Met Arg Pro Pro Leu Ser
                165                 170                 175     
Lys Glu Leu Trp Phe Ser Asp Asp Pro Asn Val Thr Lys Thr Leu Arg
            180                 185                 190         
Phe Lys Gln Trp Asn Gly Lys Glu Arg Ser Ile Tyr Phe Gln Pro Pro
        195                 200                 205             
Ser Phe Tyr Val Ser Ala Gln Asp Leu Pro His Ile Glu Asn Gly Gly
    210                 215                 220                 
Val Ala Val Leu Thr Gly Lys Lys Val Val Gln Leu Asp Val Arg Asp
225                 230                 235                 240 
Asn Met Val Lys Leu Asn Asp Gly Ser Gln Ile Thr Tyr Glu Lys Cys
                245                 250                 255     
Leu Ile Ala Thr Gly Gly Thr Pro Arg Ser Leu Ser Ala Ile Asp Arg
            260                 265                 270         
Ala Gly Ala Glu Val Lys Ser Arg Thr Thr Leu Phe Arg Lys Ile Gly
        275                 280                 285             
Asp Phe Arg Ser Leu Glu Lys Ile Ser Arg Glu Val Lys Ser Ile Thr
    290                 295                 300                 
Ile Ile Gly Gly Gly Phe Leu Gly Ser Glu Leu Ala Cys Ala Leu Gly
305                 310                 315                 320 
Arg Lys Ala Arg Ala Leu Gly Thr Glu Val Ile Gln Leu Phe Pro Glu
                325                 330                 335     
Lys Gly Asn Met Gly Lys Ile Leu Pro Glu Tyr Leu Ser Asn Trp Thr
            340                 345                 350         
Met Glu Lys Val Arg Arg Glu Gly Val Lys Val Met Pro Asn Ala Ile
        355                 360                 365             
Val Gln Ser Val Gly Val Ser Ser Gly Lys Leu Leu Ile Lys Leu Lys
    370                 375                 380                 
Asp Gly Arg Lys Val Glu Thr Asp His Ile Val Ala Ala Val Gly Leu
385                 390                 395                 400 
Glu Pro Asn Val Glu Leu Ala Lys Thr Gly Gly Leu Glu Ile Asp Ser
                405                 410                 415     
Asp Phe Gly Gly Phe Arg Val Asn Ala Glu Leu Gln Ala Arg Ser Asn
            420                 425                 430         
Ile Trp Val Ala Gly Asp Ala Ala Cys Phe Tyr Asp Ile Lys Leu Gly
        435                 440                 445             
Arg Arg Arg Val Glu His His Asp His Ala Val Val Ser Gly Arg Leu
    450                 455                 460                 
Ala Gly Glu Asn Met Thr Gly Ala Ala Lys Pro Tyr Trp His Gln Ser
465                 470                 475                 480 
Met Phe Trp Ser Asp Leu Gly Pro Asp Val Gly Tyr Glu Ala Ile Gly
                485                 490                 495     
Leu Val Asp Ser Ser Leu Pro Thr Val Gly Val Phe Ala Lys Ala Thr
            500                 505                 510         
Ala Gln Asp Asn Pro Lys Ser Ala Thr Glu Gln Ser Gly Thr Gly Ile
        515                 520                 525             
Arg Ser Glu Ser Glu Thr Glu Ser Glu Ala Ser Glu Ile Thr Ile Pro
    530                 535                 540                 
Pro Ser Thr Pro Ala Val Pro Gln Ala Pro Val Gln Gly Glu Asp Tyr
545                 550                 555                 560 
Gly Lys Gly Val Ile Phe Tyr Leu Arg Asp Lys Val Val Val Gly Ile
                565                 570                 575     
Val Leu Trp Asn Ile Phe Asn Arg Met Pro Ile Ala Arg Lys Ile Ile
            580                 585                 590         
Lys Asp Gly Glu Gln His Glu Asp Leu Asn Glu Val Ala Lys Leu Phe
        595                 600                 605             
Asn Ile His Glu Asp
    610             


<210> 572
<211> 474
<212> PRT
<213> Homo sapiens

<400> 572
Met Ser Ser Glu Asp Arg Glu Ala Gln Glu Asp Glu Leu Leu Ala Leu
 1               5                  10                  15      
Ala Ser Ile Tyr Asp Gly Asp Glu Phe Arg Lys Ala Glu Ser Val Gln
            20                  25                  30          
Gly Gly Glu Thr Arg Ile Tyr Leu Asp Leu Pro Gln Asn Phe Lys Ile
        35                  40                  45              
Phe Val Ser Gly Asn Ser Asn Glu Cys Leu Gln Asn Ser Gly Phe Glu
    50                  55                  60                  
Tyr Thr Ile Cys Phe Leu Pro Pro Leu Val Leu Asn Phe Glu Leu Pro
65                  70                  75                  80  
Pro Asp Tyr Pro Ser Ser Ser Pro Pro Ser Phe Thr Leu Ser Gly Lys
                85                  90                  95      
Trp Leu Ser Pro Thr Gln Leu Ser Ala Leu Cys Lys His Leu Asp Asn
            100                 105                 110         
Leu Trp Glu Glu His Arg Gly Ser Val Val Leu Phe Ala Trp Met Gln
        115                 120                 125             
Phe Leu Lys Glu Glu Thr Leu Ala Tyr Leu Asn Ile Val Ser Pro Phe
    130                 135                 140                 
Glu Leu Lys Ile Gly Ser Gln Lys Lys Val Gln Arg Arg Thr Ala Gln
145                 150                 155                 160 
Ala Ser Pro Asn Thr Glu Leu Asp Phe Gly Gly Ala Ala Gly Ser Asp
                165                 170                 175     
Val Asp Gln Glu Glu Ile Val Asp Glu Arg Ala Val Gln Asp Val Glu
            180                 185                 190         
Ser Leu Ser Asn Leu Ile Gln Glu Ile Leu Asp Phe Asp Gln Ala Gln
        195                 200                 205             
Gln Ile Lys Cys Phe Asn Ser Lys Leu Phe Leu Cys Ser Ile Cys Phe
    210                 215                 220                 
Cys Glu Lys Leu Gly Ser Glu Cys Met Tyr Phe Leu Glu Cys Arg His
225                 230                 235                 240 
Val Tyr Cys Lys Ala Cys Leu Lys Asp Tyr Phe Glu Ile Gln Ile Arg
                245                 250                 255     
Asp Gly Gln Val Gln Cys Leu Asn Cys Pro Glu Pro Lys Cys Pro Ser
            260                 265                 270         
Val Ala Thr Pro Gly Gln Val Lys Glu Leu Val Glu Ala Glu Leu Phe
        275                 280                 285             
Ala Arg Tyr Asp Arg Leu Leu Leu Gln Ser Ser Leu Asp Leu Met Ala
    290                 295                 300                 
Asp Val Val Tyr Cys Pro Arg Pro Cys Cys Gln Leu Pro Val Met Gln
305                 310                 315                 320 
Glu Pro Gly Cys Thr Met Gly Ile Cys Ser Ser Cys Asn Phe Ala Phe
                325                 330                 335     
Cys Thr Leu Cys Arg Leu Thr Tyr His Gly Val Ser Pro Cys Lys Val
            340                 345                 350         
Thr Ala Glu Lys Leu Met Asp Leu Arg Asn Glu Tyr Leu Gln Ala Asp
        355                 360                 365             
Glu Ala Asn Lys Arg Leu Leu Asp Gln Arg Tyr Gly Lys Arg Val Ile
    370                 375                 380                 
Gln Lys Ala Leu Glu Glu Met Glu Ser Lys Glu Trp Leu Glu Lys Asn
385                 390                 395                 400 
Ser Lys Ser Cys Pro Cys Cys Gly Thr Pro Ile Glu Lys Leu Asp Gly
                405                 410                 415     
Cys Asn Lys Met Thr Cys Thr Gly Cys Met Gln Tyr Phe Cys Trp Ile
            420                 425                 430         
Cys Met Gly Ser Leu Ser Arg Ala Asn Pro Tyr Lys His Phe Asn Asp
        435                 440                 445             
Pro Gly Ser Pro Cys Phe Asn Arg Leu Phe Tyr Ala Val Asp Val Asp
    450                 455                 460                 
Asp Asp Ile Trp Glu Asp Glu Val Glu Asp
465                 470                 


<210> 573
<211> 395
<212> PRT
<213> Homo sapiens

<400> 573
Met Pro Gly Arg Ser Cys Val Ala Leu Val Leu Leu Ala Ala Ala Val
 1               5                  10                  15      
Ser Cys Ala Val Ala Gln His Ala Pro Pro Trp Thr Glu Asp Cys Arg
            20                  25                  30          
Lys Ser Thr Tyr Pro Pro Ser Gly Pro Thr Tyr Arg Gly Ala Val Pro
        35                  40                  45              
Trp Tyr Thr Ile Asn Leu Asp Leu Pro Pro Tyr Lys Arg Trp His Glu
    50                  55                  60                  
Leu Met Leu Asp Lys Ala Pro Met Leu Lys Val Ile Val Asn Ser Leu
65                  70                  75                  80  
Lys Asn Met Ile Asn Thr Phe Val Pro Ser Gly Lys Val Met Gln Val
                85                  90                  95      
Val Asp Glu Lys Leu Pro Gly Leu Leu Gly Asn Phe Pro Gly Pro Phe
            100                 105                 110         
Glu Glu Glu Met Lys Gly Ile Ala Ala Val Thr Asp Ile Pro Leu Gly
        115                 120                 125             
Glu Ile Ile Ser Phe Asn Ile Phe Tyr Glu Leu Phe Thr Ile Cys Thr
    130                 135                 140                 
Ser Ile Val Ala Glu Asp Lys Lys Gly His Leu Ile His Gly Arg Asn
145                 150                 155                 160 
Met Asp Phe Gly Val Phe Leu Gly Trp Asn Ile Asn Asn Asp Thr Trp
                165                 170                 175     
Val Ile Thr Glu Gln Leu Lys Pro Leu Thr Val Asn Leu Asp Phe Gln
            180                 185                 190         
Arg Asn Asn Lys Thr Val Phe Lys Ala Ser Ser Phe Ala Gly Tyr Val
        195                 200                 205             
Gly Met Leu Thr Gly Phe Lys Pro Gly Leu Phe Ser Leu Thr Leu Asn
    210                 215                 220                 
Glu Arg Phe Ser Ile Asn Gly Gly Tyr Leu Gly Ile Leu Glu Trp Ile
225                 230                 235                 240 
Leu Gly Lys Lys Asp Ala Met Trp Ile Gly Phe Leu Thr Arg Thr Val
                245                 250                 255     
Leu Glu Asn Ser Thr Ser Tyr Glu Glu Ala Lys Asn Leu Leu Thr Lys
            260                 265                 270         
Thr Lys Ile Leu Ala Pro Ala Tyr Phe Ile Leu Gly Gly Asn Gln Ser
        275                 280                 285             
Gly Glu Gly Cys Val Ile Thr Arg Asp Arg Lys Glu Ser Leu Asp Val
    290                 295                 300                 
Tyr Glu Leu Asp Ala Lys Gln Gly Arg Trp Tyr Val Val Gln Thr Asn
305                 310                 315                 320 
Tyr Asp Arg Trp Lys His Pro Phe Phe Leu Asp Asp Arg Arg Thr Pro
                325                 330                 335     
Ala Lys Met Cys Leu Asn Arg Thr Ser Gln Glu Asn Ile Ser Phe Glu
            340                 345                 350         
Thr Met Tyr Asp Val Leu Ser Thr Lys Pro Val Leu Asn Lys Leu Thr
        355                 360                 365             
Val Tyr Thr Thr Leu Ile Asp Val Thr Lys Gly Gln Phe Glu Thr Tyr
    370                 375                 380                 
Leu Arg Asp Cys Pro Asp Pro Cys Ile Gly Trp
385                 390                 395 


<210> 574
<211> 419
<212> PRT
<213> Homo sapiens

<400> 574
Met Pro Leu Ser Asp Phe Ile Leu Ala Leu Lys Asp Asn Pro Tyr Phe
 1               5                  10                  15      
Gly Ala Gly Phe Gly Leu Val Gly Val Gly Thr Ala Leu Ala Leu Ala
            20                  25                  30          
Arg Lys Gly Val Gln Leu Gly Leu Val Ala Phe Arg Arg His Tyr Met
        35                  40                  45              
Ile Thr Leu Glu Val Pro Ala Arg Asp Arg Ser Tyr Ala Trp Leu Leu
    50                  55                  60                  
Ser Trp Leu Thr Arg His Ser Thr Arg Thr Gln His Leu Ser Val Glu
65                  70                  75                  80  
Thr Ser Tyr Leu Gln His Glu Ser Gly Arg Ile Ser Thr Lys Phe Glu
                85                  90                  95      
Phe Val Pro Ser Pro Gly Asn His Phe Ile Trp Tyr Arg Gly Lys Trp
            100                 105                 110         
Ile Arg Val Glu Arg Ser Arg Glu Met Gln Met Ile Asp Leu Gln Thr
        115                 120                 125             
Gly Thr Pro Trp Glu Ser Val Thr Phe Thr Ala Leu Gly Thr Asp Arg
    130                 135                 140                 
Lys Val Phe Phe Asn Ile Leu Glu Glu Ala Arg Glu Leu Ala Leu Gln
145                 150                 155                 160 
Gln Glu Glu Gly Lys Thr Val Met Tyr Thr Ala Val Gly Ser Glu Trp
                165                 170                 175     
Arg Pro Phe Gly Tyr Pro Arg Arg Arg Arg Pro Leu Asn Ser Val Val
            180                 185                 190         
Leu Gln Gln Gly Leu Ala Asp Arg Ile Val Arg Asp Val Gln Glu Phe
        195                 200                 205             
Ile Asp Asn Pro Lys Trp Tyr Thr Asp Arg Gly Ile Pro Tyr Arg Arg
    210                 215                 220                 
Gly Tyr Leu Leu Tyr Gly Pro Pro Gly Cys Gly Lys Ser Ser Phe Ile
225                 230                 235                 240 
Thr Ala Leu Ala Gly Glu Leu Glu His Ser Ile Cys Leu Leu Ser Leu
                245                 250                 255     
Thr Asp Ser Ser Leu Ser Asp Asp Arg Leu Asn His Leu Leu Ser Val
            260                 265                 270         
Ala Pro Gln Gln Ser Leu Val Leu Leu Glu Asp Val Asp Ala Ala Phe
        275                 280                 285             
Leu Ser Arg Asp Leu Ala Val Glu Asn Pro Val Lys Tyr Gln Gly Leu
    290                 295                 300                 
Gly Arg Leu Thr Phe Ser Gly Leu Leu Asn Ala Leu Asp Gly Val Ala
305                 310                 315                 320 
Ser Thr Glu Ala Arg Ile Val Phe Met Thr Thr Asn His Val Asp Arg
                325                 330                 335     
Leu Asp Pro Ala Leu Ile Arg Pro Gly Arg Val Asp Leu Lys Glu Tyr
            340                 345                 350         
Val Gly Tyr Cys Ser His Trp Gln Leu Thr Gln Met Phe Gln Arg Phe
        355                 360                 365             
Tyr Pro Gly Gln Ala Pro Ser Leu Ala Glu Asn Phe Ala Glu His Val
    370                 375                 380                 
Leu Arg Ala Thr Asn Gln Ile Ser Pro Ala Gln Val Gln Gly Tyr Phe
385                 390                 395                 400 
Met Leu Tyr Lys Asn Asp Pro Val Gly Ala Ile His Asn Ala Glu Ser
                405                 410                 415     
Leu Arg Arg
            


<210> 575
<211> 576
<212> PRT
<213> Homo sapiens

<400> 575
Met Ala Ala Ser Glu Thr Val Arg Leu Arg Leu Gln Phe Asp Tyr Pro
 1               5                  10                  15      
Pro Pro Ala Thr Pro His Cys Thr Ala Phe Trp Leu Leu Val Asp Leu
            20                  25                  30          
Asn Arg Cys Arg Val Val Thr Asp Leu Ile Ser Leu Ile Arg Gln Arg
        35                  40                  45              
Phe Gly Phe Ser Ser Gly Ala Phe Leu Gly Leu Tyr Leu Glu Gly Gly
    50                  55                  60                  
Leu Leu Pro Pro Ala Glu Ser Ala Arg Leu Val Arg Asp Asn Asp Cys
65                  70                  75                  80  
Leu Arg Val Lys Leu Glu Glu Arg Gly Val Ala Glu Asn Ser Val Val
                85                  90                  95      
Ile Ser Asn Gly Asp Ile Asn Leu Ser Leu Arg Lys Ala Lys Lys Arg
            100                 105                 110         
Ala Phe Gln Leu Glu Glu Gly Glu Glu Thr Glu Pro Asp Cys Lys Tyr
        115                 120                 125             
Ser Lys Lys His Trp Lys Ser Arg Glu Asn Asn Asn Asn Asn Glu Lys
    130                 135                 140                 
Val Leu Asp Leu Glu Pro Lys Ala Val Thr Asp Gln Thr Val Ser Lys
145                 150                 155                 160 
Lys Asn Lys Arg Lys Asn Lys Ala Thr Cys Gly Thr Val Gly Asp Asp
                165                 170                 175     
Asn Glu Glu Ala Lys Arg Lys Ser Pro Lys Lys Lys Glu Lys Cys Glu
            180                 185                 190         
Tyr Lys Lys Lys Ala Lys Asn Pro Lys Ser Pro Lys Val Gln Ala Val
        195                 200                 205             
Lys Asp Trp Ala Asn Gln Arg Cys Ser Ser Pro Lys Gly Ser Ala Arg
    210                 215                 220                 
Asn Ser Leu Val Lys Ala Lys Arg Lys Gly Ser Val Ser Val Cys Ser
225                 230                 235                 240 
Lys Glu Ser Pro Ser Ser Ser Ser Glu Ser Glu Ser Cys Asp Glu Ser
                245                 250                 255     
Ile Ser Asp Gly Pro Ser Lys Val Thr Leu Glu Ala Arg Asn Ser Ser
            260                 265                 270         
Glu Lys Leu Pro Thr Glu Leu Ser Lys Glu Glu Pro Ser Thr Lys Asn
        275                 280                 285             
Thr Thr Ala Asp Lys Leu Ala Ile Lys Leu Gly Phe Ser Leu Thr Pro
    290                 295                 300                 
Ser Lys Gly Lys Thr Ser Gly Thr Thr Ser Ser Ser Ser Asp Ser Ser
305                 310                 315                 320 
Ala Glu Ser Asp Asp Gln Cys Leu Met Ser Ser Ser Thr Pro Glu Cys
                325                 330                 335     
Ala Ala Gly Phe Leu Lys Thr Val Gly Leu Phe Ala Gly Arg Gly Arg
            340                 345                 350         
Pro Gly Pro Gly Leu Ser Ser Gln Thr Ala Gly Ala Ala Gly Trp Arg
        355                 360                 365             
Arg Ser Gly Ser Asn Gly Gly Gly Gln Ala Pro Gly Ala Ser Pro Ser
    370                 375                 380                 
Val Ser Leu Pro Ala Ser Leu Gly Arg Gly Trp Gly Arg Glu Glu Asn
385                 390                 395                 400 
Leu Phe Ser Trp Lys Gly Ala Lys Gly Arg Gly Met Arg Gly Arg Gly
                405                 410                 415     
Arg Gly Arg Gly His Pro Val Ser Cys Val Val Asn Arg Ser Thr Asp
            420                 425                 430         
Asn Gln Arg Gln Gln Gln Leu Asn Asp Val Val Lys Asn Ser Ser Thr
        435                 440                 445             
Ile Ile Gln Asn Pro Val Glu Thr Pro Lys Lys Asp Tyr Ser Leu Leu
    450                 455                 460                 
Pro Leu Leu Ala Ala Ala Pro Gln Val Gly Glu Lys Ile Ala Phe Lys
465                 470                 475                 480 
Leu Leu Glu Leu Thr Ser Ser Tyr Ser Pro Asp Val Ser Asp Tyr Lys
                485                 490                 495     
Glu Gly Arg Ile Leu Ser His Asn Pro Glu Thr Gln Gln Val Asp Ile
            500                 505                 510         
Glu Ile Leu Ser Ser Leu Pro Ala Leu Arg Glu Pro Gly Lys Phe Asp
        515                 520                 525             
Leu Val Tyr His Asn Glu Asn Gly Ala Glu Val Val Glu Tyr Ala Val
    530                 535                 540                 
Thr Gln Glu Ser Lys Ile Thr Val Phe Trp Lys Glu Leu Ile Asp Pro
545                 550                 555                 560 
Arg Leu Ile Ile Glu Ser Pro Ser Asn Thr Ser Ser Thr Glu Pro Ala
                565                 570                 575     


<210> 576
<211> 1224
<212> PRT
<213> Homo sapiens

<400> 576
Met Leu Thr Lys Phe Glu Thr Lys Ser Ala Arg Val Lys Gly Leu Ser
 1               5                  10                  15      
Phe His Pro Lys Arg Pro Trp Ile Leu Thr Ser Leu His Asn Gly Val
            20                  25                  30          
Ile Gln Leu Trp Asp Tyr Arg Met Cys Thr Leu Ile Asp Lys Phe Asp
        35                  40                  45              
Glu His Asp Gly Pro Val Arg Gly Ile Asp Phe His Lys Gln Gln Pro
    50                  55                  60                  
Leu Phe Val Ser Gly Gly Asp Asp Tyr Lys Ile Lys Val Trp Asn Tyr
65                  70                  75                  80  
Lys Leu Arg Arg Cys Leu Phe Thr Leu Leu Gly His Leu Asp Tyr Ile
                85                  90                  95      
Arg Thr Thr Phe Phe His His Glu Tyr Pro Trp Ile Leu Ser Ala Ser
            100                 105                 110         
Asp Asp Gln Thr Ile Arg Val Trp Asn Trp Gln Ser Arg Thr Cys Val
        115                 120                 125             
Cys Val Leu Thr Gly His Asn His Tyr Val Met Cys Ala Gln Phe His
    130                 135                 140                 
Pro Thr Glu Asp Leu Val Val Ser Ala Ser Leu Asp Gln Thr Val Arg
145                 150                 155                 160 
Val Trp Asp Ile Ser Gly Leu Arg Lys Lys Asn Leu Ser Pro Gly Ala
                165                 170                 175     
Val Glu Ser Asp Val Arg Gly Ile Thr Gly Val Asp Leu Phe Gly Thr
            180                 185                 190         
Thr Asp Ala Val Val Lys His Val Leu Glu Gly His Asp Arg Gly Val
        195                 200                 205             
Asn Trp Ala Ala Phe His Pro Thr Met Pro Leu Ile Val Ser Gly Ala
    210                 215                 220                 
Asp Asp Arg Gln Val Lys Ile Trp Arg Met Asn Glu Ser Lys Ala Trp
225                 230                 235                 240 
Glu Val Asp Thr Cys Arg Gly His Tyr Asn Asn Val Ser Cys Ala Val
                245                 250                 255     
Phe His Pro Arg Gln Glu Leu Ile Leu Ser Asn Ser Glu Asp Lys Ser
            260                 265                 270         
Ile Arg Val Trp Asp Met Ser Lys Arg Thr Gly Val Gln Thr Phe Arg
        275                 280                 285             
Arg Asp His Asp Arg Phe Trp Val Leu Ala Ala His Pro Asn Leu Asn
    290                 295                 300                 
Leu Phe Ala Ala Gly His Asp Gly Gly Met Ile Val Phe Lys Leu Glu
305                 310                 315                 320 
Arg Glu Arg Pro Ala Tyr Ala Val His Gly Asn Met Leu His Tyr Val
                325                 330                 335     
Lys Asp Arg Phe Leu Arg Gln Leu Asp Phe Asn Ser Ser Lys Asp Val
            340                 345                 350         
Ala Val Met Gln Leu Arg Ser Gly Ser Lys Phe Pro Val Phe Asn Met
        355                 360                 365             
Ser Tyr Asn Pro Ala Glu Asn Ala Val Leu Leu Cys Thr Arg Ala Ser
    370                 375                 380                 
Asn Leu Glu Asn Ser Thr Tyr Asp Leu Tyr Thr Ile Pro Lys Asp Ala
385                 390                 395                 400 
Asp Ser Gln Asn Pro Asp Ala Pro Glu Gly Lys Arg Ser Ser Gly Leu
                405                 410                 415     
Thr Ala Val Trp Val Ala Arg Asn Arg Phe Ala Val Leu Asp Arg Met
            420                 425                 430         
His Ser Leu Leu Ile Lys Asn Leu Lys Asn Glu Ile Thr Lys Lys Val
        435                 440                 445             
Gln Val Pro Asn Cys Asp Glu Ile Phe Tyr Ala Gly Thr Gly Asn Leu
    450                 455                 460                 
Leu Leu Arg Asp Ala Asp Ser Ile Thr Leu Phe Asp Val Gln Gln Lys
465                 470                 475                 480 
Arg Thr Leu Ala Ser Val Lys Ile Ser Lys Val Lys Tyr Val Ile Trp
                485                 490                 495     
Ser Ala Asp Met Ser His Val Ala Leu Leu Ala Lys His Ala Ile Val
            500                 505                 510         
Ile Cys Asn Arg Lys Leu Asp Ala Leu Cys Asn Ile His Glu Asn Ile
        515                 520                 525             
Arg Val Lys Ser Gly Ala Trp Asp Glu Ser Gly Val Phe Ile Tyr Thr
    530                 535                 540                 
Thr Ser Asn His Ile Lys Tyr Ala Val Thr Thr Gly Asp His Gly Ile
545                 550                 555                 560 
Ile Arg Thr Leu Asp Leu Pro Ile Tyr Val Thr Arg Val Lys Gly Asn
                565                 570                 575     
Asn Val Tyr Cys Leu Asp Arg Glu Cys Arg Pro Arg Val Leu Thr Ile
            580                 585                 590         
Asp Pro Thr Glu Phe Lys Phe Lys Leu Ala Leu Ile Asn Arg Lys Tyr
        595                 600                 605             
Asp Glu Val Leu His Met Val Arg Asn Ala Lys Leu Val Gly Gln Ser
    610                 615                 620                 
Ile Ile Ala Tyr Leu Gln Lys Lys Gly Tyr Pro Glu Val Ala Leu His
625                 630                 635                 640 
Phe Val Lys Asp Glu Lys Thr Arg Phe Ser Leu Ala Leu Glu Cys Gly
                645                 650                 655     
Asn Ile Glu Ile Ala Leu Glu Ala Ala Lys Ala Leu Asp Asp Lys Asn
            660                 665                 670         
Cys Trp Glu Lys Leu Gly Glu Val Ala Leu Leu Gln Gly Asn His Gln
        675                 680                 685             
Ile Val Glu Met Cys Tyr Gln Arg Thr Lys Asn Phe Asp Lys Val Ser
    690                 695                 700                 
Phe Leu Tyr Leu Ile Thr Gly Asn Leu Glu Lys Leu Arg Lys Met Met
705                 710                 715                 720 
Lys Ile Ala Glu Ile Arg Lys Asp Met Ser Gly His Tyr Gln Asn Ala
                725                 730                 735     
Leu Tyr Leu Gly Asp Val Ser Glu Arg Val Arg Ile Leu Lys Asn Cys
            740                 745                 750         
Gly Gln Lys Ser Leu Ala Tyr Leu Thr Ala Ala Thr His Gly Leu Asp
        755                 760                 765             
Glu Glu Ala Glu Ser Leu Lys Glu Thr Phe Asp Pro Glu Lys Glu Thr
    770                 775                 780                 
Ile Pro Asp Ile Asp Pro Asn Ala Lys Leu Leu Gln Pro Pro Ala Pro
785                 790                 795                 800 
Ile Met Pro Leu Asp Thr Asn Trp Pro Leu Leu Thr Val Ser Lys Gly
                805                 810                 815     
Phe Phe Glu Gly Thr Ile Ala Ser Lys Gly Lys Gly Gly Ala Leu Ala
            820                 825                 830         
Ala Asp Ile Asp Ile Asp Thr Val Gly Thr Glu Gly Trp Gly Glu Asp
        835                 840                 845             
Ala Glu Leu Gln Leu Asp Glu Asp Gly Phe Val Glu Ala Thr Glu Gly
    850                 855                 860                 
Leu Gly Asp Asp Ala Leu Gly Lys Gly Gln Glu Glu Gly Gly Gly Trp
865                 870                 875                 880 
Asp Val Glu Glu Asp Leu Glu Leu Pro Pro Glu Leu Asp Ile Ser Pro
                885                 890                 895     
Gly Ala Ala Gly Gly Ala Glu Asp Gly Phe Phe Val Pro Pro Thr Lys
            900                 905                 910         
Gly Thr Ser Pro Thr Gln Ile Trp Cys Asn Asn Ser Gln Leu Pro Val
        915                 920                 925             
Asp His Ile Leu Ala Gly Ser Phe Glu Thr Ala Met Arg Leu Leu His
    930                 935                 940                 
Asp Gln Val Gly Val Ile Gln Phe Gly Pro Tyr Lys Gln Leu Phe Leu
945                 950                 955                 960 
Gln Thr Tyr Ala Arg Gly Arg Thr Thr Tyr Gln Ala Leu Pro Cys Leu
                965                 970                 975     
Pro Ser Met Tyr Gly Tyr Pro Asn Arg Asn Trp Lys Asp Ala Gly Leu
            980                 985                 990         
Lys Asn Gly Val Pro Ala Val Gly Leu Lys Leu Asn Asp Leu Ile Gln
        995                 1000                1005            
Arg Leu Gln Leu Cys Tyr Gln Leu Thr Thr Val Gly Lys Phe Glu Glu
    1010                1015                1020                
Ala Val Glu Lys Phe Arg Ser Ile Leu Leu Ser Val Pro Leu Leu Val
1025                1030                1035                1040
Val Asp Asn Lys Gln Glu Ile Ala Glu Ala Gln Gln Leu Ile Thr Ile
                1045                1050                1055    
Cys Arg Glu Tyr Ile Val Gly Leu Ser Val Glu Thr Glu Arg Lys Lys
            1060                1065                1070        
Leu Pro Lys Glu Thr Leu Glu Gln Gln Lys Arg Ile Cys Glu Met Ala
        1075                1080                1085            
Ala Tyr Phe Thr His Ser Asn Leu Gln Pro Val His Met Ile Leu Val
    1090                1095                1100                
Leu Arg Thr Ala Leu Asn Leu Phe Phe Lys Leu Lys Asn Phe Lys Thr
1105                1110                1115                1120
Ala Ala Thr Phe Ala Arg Arg Leu Leu Glu Leu Gly Pro Lys Pro Glu
                1125                1130                1135    
Val Ala Gln Gln Thr Arg Lys Ile Leu Ser Ala Cys Glu Lys Asn Pro
            1140                1145                1150        
Thr Asp Ala Tyr Gln Leu Asn Tyr Asp Met His Asn Pro Phe Asp Ile
        1155                1160                1165            
Cys Ala Ala Ser Tyr Arg Pro Ile Tyr Arg Gly Lys Pro Val Glu Lys
    1170                1175                1180                
Cys Pro Leu Ser Gly Ala Cys Tyr Ser Pro Glu Phe Lys Gly Gln Ile
1185                1190                1195                1200
Cys Arg Val Thr Thr Val Thr Glu Ile Gly Lys Asp Val Ile Gly Leu
                1205                1210                1215    
Arg Ile Ser Pro Leu Gln Phe Arg
            1220                


<210> 577
<211> 150
<212> PRT
<213> Homo sapiens

<400> 577
Met Leu Gly Ala Ala Leu Arg Arg Cys Ala Val Ala Ala Thr Thr Arg
 1               5                  10                  15      
Ala Asp Pro Arg Gly Leu Leu His Ser Ala Arg Thr Pro Gly Pro Ala
            20                  25                  30          
Val Ala Ile Gln Ser Val Arg Cys Tyr Ser His Gly Ser Gln Glu Thr
        35                  40                  45              
Asp Glu Glu Phe Asp Ala Arg Trp Val Thr Tyr Phe Asn Lys Pro Asp
    50                  55                  60                  
Ile Asp Ala Trp Glu Leu Arg Lys Gly Ile Asn Thr Leu Val Thr Tyr
65                  70                  75                  80  
Asp Met Val Pro Glu Pro Lys Ile Ile Asp Ala Ala Leu Arg Ala Cys
                85                  90                  95      
Arg Arg Leu Asn Asp Phe Ala Ser Leu Val Arg Ile Leu Glu Val Val
            100                 105                 110         
Lys Asp Lys Ala Gly Pro His Lys Glu Ile Tyr Pro Tyr Val Ile Gln
        115                 120                 125             
Glu Leu Arg Pro Thr Leu Asn Glu Leu Gly Ile Ser Thr Pro Glu Glu
    130                 135                 140                 
Leu Gly Leu Asp Lys Val
145                 150 


<210> 578
<211> 75
<212> PRT
<213> Homo sapiens

<400> 578
Met Ala Pro Glu Val Leu Pro Lys Pro Arg Met Arg Gly Leu Leu Ala
 1               5                  10                  15      
Arg Arg Leu Arg Asn His Met Ala Val Ala Phe Val Leu Ser Leu Gly
            20                  25                  30          
Val Ala Ala Leu Tyr Lys Phe Arg Val Ala Asp Gln Arg Lys Lys Ala
        35                  40                  45              
Tyr Ala Asp Phe Tyr Arg Asn Tyr Asp Val Met Lys Asp Phe Glu Glu
    50                  55                  60                  
Met Arg Lys Ala Gly Ile Phe Gln Ser Val Lys
65                  70                  75  


<210> 579
<211> 398
<212> PRT
<213> Homo sapiens

<400> 579
Met Met Leu Lys Gly Ile Thr Arg Leu Ile Ser Arg Ile His Lys Leu
 1               5                  10                  15      
Asp Pro Gly Arg Phe Leu His Met Gly Thr Gln Ala Arg Gln Ser Ile
            20                  25                  30          
Ala Ala His Leu Asp Asn Gln Val Pro Val Glu Ser Pro Arg Ala Ile
        35                  40                  45              
Ser Arg Thr Asn Glu Asn Asp Pro Ala Lys His Gly Asp Gln His Glu
    50                  55                  60                  
Gly Gln His Tyr Asn Ile Ser Pro Gln Asp Leu Glu Thr Val Phe Pro
65                  70                  75                  80  
His Gly Leu Pro Pro Arg Phe Val Met Gln Val Lys Thr Phe Ser Glu
                85                  90                  95      
Ala Cys Leu Met Val Arg Lys Pro Ala Leu Glu Leu Leu His Tyr Leu
            100                 105                 110         
Lys Asn Thr Ser Phe Ala Tyr Pro Ala Ile Arg Tyr Leu Leu Tyr Gly
        115                 120                 125             
Glu Lys Gly Thr Gly Lys Thr Leu Ser Leu Cys His Val Ile His Phe
    130                 135                 140                 
Cys Ala Lys Gln Asp Trp Leu Ile Leu His Ile Pro Asp Ala His Leu
145                 150                 155                 160 
Trp Val Lys Asn Cys Arg Asp Leu Leu Gln Ser Ser Tyr Asn Lys Gln
                165                 170                 175     
Arg Phe Asp Gln Pro Leu Glu Ala Ser Thr Trp Leu Lys Asn Phe Lys
            180                 185                 190         
Thr Thr Asn Glu Arg Phe Leu Asn Gln Ile Lys Val Gln Glu Lys Tyr
        195                 200                 205             
Val Trp Asn Lys Arg Glu Ser Thr Glu Lys Gly Ser Pro Leu Gly Glu
    210                 215                 220                 
Val Val Glu Gln Gly Ile Thr Arg Val Arg Asn Ala Thr Asp Ala Val
225                 230                 235                 240 
Gly Ile Val Leu Lys Glu Leu Lys Arg Gln Ser Ser Leu Gly Met Phe
                245                 250                 255     
His Leu Leu Val Ala Val Asp Gly Ile Asn Ala Leu Trp Gly Arg Thr
            260                 265                 270         
Thr Leu Lys Arg Glu Asp Lys Ser Pro Ile Ala Pro Glu Glu Leu Ala
        275                 280                 285             
Leu Val His Asn Leu Arg Lys Met Met Lys Asn Asp Trp His Gly Gly
    290                 295                 300                 
Ala Ile Val Ser Ala Leu Ser Gln Thr Gly Ser Leu Phe Lys Pro Arg
305                 310                 315                 320 
Lys Ala Tyr Leu Pro Gln Glu Leu Leu Gly Lys Glu Gly Phe Asp Ala
                325                 330                 335     
Leu Asp Pro Phe Ile Pro Ile Leu Val Ser Asn Tyr Asn Pro Lys Glu
            340                 345                 350         
Phe Glu Ser Cys Ile Gln Tyr Tyr Leu Glu Asn Asn Trp Leu Gln His
        355                 360                 365             
Glu Lys Ala Pro Thr Glu Glu Gly Lys Lys Glu Leu Leu Phe Leu Ser
    370                 375                 380                 
Asn Ala Asn Pro Ser Leu Leu Glu Arg His Cys Ala Tyr Leu
385                 390                 395             


<210> 580
<211> 398
<212> PRT
<213> Homo sapiens

<400> 580
Met Met Leu Lys Gly Ile Thr Arg Leu Ile Ser Arg Ile His Lys Leu
 1               5                  10                  15      
Asp Pro Gly Arg Phe Leu His Met Gly Thr Gln Ala Arg Gln Ser Ile
            20                  25                  30          
Ala Ala His Leu Asp Asn Gln Val Pro Val Glu Ser Pro Arg Ala Ile
        35                  40                  45              
Ser Arg Thr Asn Glu Asn Asp Pro Ala Lys His Gly Asp Gln His Glu
    50                  55                  60                  
Gly Gln His Tyr Asn Ile Ser Pro Gln Asp Leu Glu Thr Val Phe Pro
65                  70                  75                  80  
His Gly Leu Pro Pro Arg Phe Val Met Gln Val Lys Thr Phe Ser Glu
                85                  90                  95      
Ala Cys Leu Met Val Arg Lys Pro Ala Leu Glu Leu Leu His Tyr Leu
            100                 105                 110         
Lys Asn Thr Ser Phe Ala Tyr Pro Ala Ile Arg Tyr Leu Leu Tyr Gly
        115                 120                 125             
Glu Lys Gly Thr Gly Lys Thr Leu Ser Leu Cys His Val Ile His Phe
    130                 135                 140                 
Cys Ala Lys Gln Asp Trp Leu Ile Leu His Ile Pro Asp Ala His Leu
145                 150                 155                 160 
Trp Val Lys Asn Cys Arg Asp Leu Leu Gln Ser Ser Tyr Asn Lys Gln
                165                 170                 175     
Arg Phe Asp Gln Pro Leu Glu Ala Ser Thr Trp Leu Lys Asn Phe Lys
            180                 185                 190         
Thr Thr Asn Glu Arg Phe Leu Asn Gln Ile Lys Val Gln Glu Lys Tyr
        195                 200                 205             
Val Trp Asn Lys Arg Glu Ser Thr Glu Lys Gly Ser Pro Leu Gly Glu
    210                 215                 220                 
Val Val Glu Gln Gly Ile Thr Arg Val Arg Asn Ala Thr Asp Ala Val
225                 230                 235                 240 
Gly Ile Val Leu Lys Glu Leu Lys Arg Gln Ser Ser Leu Gly Met Phe
                245                 250                 255     
His Leu Leu Val Ala Val Asp Gly Ile Asn Ala Leu Trp Gly Arg Thr
            260                 265                 270         
Thr Leu Lys Arg Glu Asp Lys Ser Pro Ile Ala Pro Glu Glu Leu Ala
        275                 280                 285             
Leu Val His Asn Leu Arg Lys Met Met Lys Asn Asp Trp His Gly Gly
    290                 295                 300                 
Ala Ile Val Ser Ala Leu Ser Gln Thr Gly Ser Leu Phe Lys Pro Arg
305                 310                 315                 320 
Lys Ala Tyr Leu Pro Gln Glu Leu Leu Gly Lys Glu Gly Phe Asp Ala
                325                 330                 335     
Leu Asp Pro Phe Ile Pro Ile Leu Val Ser Asn Tyr Asn Pro Lys Glu
            340                 345                 350         
Phe Glu Ser Cys Ile Gln Tyr Tyr Leu Glu Asn Asn Trp Leu Gln His
        355                 360                 365             
Glu Lys Ala Pro Thr Glu Glu Gly Lys Lys Glu Leu Leu Phe Leu Ser
    370                 375                 380                 
Asn Ala Asn Pro Ser Leu Leu Glu Arg His Cys Ala Tyr Leu
385                 390                 395             


<210> 581
<211> 102
<212> PRT
<213> Homo sapiens

<400> 581
Met Ser Ser Pro Pro Glu Gly Lys Leu Glu Thr Lys Ala Gly His Pro
 1               5                  10                  15      
Pro Ala Val Lys Ala Gly Gly Met Arg Ile Val Gln Lys His Pro His
            20                  25                  30          
Thr Gly Asp Thr Lys Glu Glu Lys Asp Lys Asp Asp Gln Glu Trp Glu
        35                  40                  45              
Ser Pro Ser Pro Pro Lys Pro Thr Val Phe Ile Ser Gly Val Ile Ala
    50                  55                  60                  
Arg Gly Asp Lys Asp Phe Pro Pro Ala Ala Ala Gln Val Ala His Gln
65                  70                  75                  80  
Lys Pro His Ala Ser Met Asp Lys His Pro Ser Pro Arg Thr Gln His
                85                  90                  95      
Ile Gln Gln Pro Arg Lys
            100         


<210> 582
<211> 1065
<212> PRT
<213> Homo sapiens

<400> 582
Met Asp Ala Ala Gly Arg Gly Cys His Leu Leu Pro Leu Pro Ala Ala
 1               5                  10                  15      
Arg Gly Pro Ala Arg Ala Pro Ala Ala Ala Ala Ala Ala Ala Ala Ser
            20                  25                  30          
Pro Pro Gly Pro Cys Ser Gly Ala Ala Cys Ala Pro Ser Ala Ala Ala
        35                  40                  45              
Gly Ala Gly Ala Met Asn Pro Ser Ser Ser Ala Gly Glu Glu Lys Gly
    50                  55                  60                  
Ala Thr Gly Gly Ser Ser Ser Ser Gly Ser Gly Ala Gly Ser Cys Cys
65                  70                  75                  80  
Leu Gly Ala Glu Gly Gly Ala Asp Pro Arg Gly Ala Gly Ser Ala Ala
                85                  90                  95      
Ala Ala Gly Ala Ala Ala Leu Asp Glu Pro Ala Ala Ala Gly Gln Lys
            100                 105                 110         
Glu Lys Asp Glu Ala Leu Glu Glu Lys Leu Arg Asn Leu Thr Phe Arg
        115                 120                 125             
Lys Gln Val Ser Tyr Arg Lys Ala Ile Ser Arg Ala Gly Leu Gln His
    130                 135                 140                 
Leu Ala Pro Ala His Pro Leu Ser Leu Pro Val Ala Asn Gly Pro Ala
145                 150                 155                 160 
Lys Glu Pro Arg Ala Thr Leu Asp Trp Ser Glu Asn Ala Val Asn Gly
                165                 170                 175     
Glu His Leu Trp Leu Glu Thr Asn Val Ser Gly Asp Leu Cys Tyr Leu
            180                 185                 190         
Gly Glu Glu Asn Cys Gln Val Arg Phe Ala Lys Ser Ala Leu Arg Arg
        195                 200                 205             
Lys Cys Ala Val Cys Lys Ile Val Val His Thr Ala Cys Ile Glu Gln
    210                 215                 220                 
Leu Glu Lys Ile Asn Phe Arg Cys Lys Pro Thr Phe Arg Glu Gly Gly
225                 230                 235                 240 
Ser Arg Ser Pro Arg Glu Asn Phe Val Arg His His Trp Val His Arg
                245                 250                 255     
Arg Arg Gln Glu Gly Lys Cys Lys Gln Cys Gly Lys Gly Phe Gln Gln
            260                 265                 270         
Lys Phe Ser Phe His Ser Lys Glu Ile Val Ala Ile Ser Cys Ser Trp
        275                 280                 285             
Cys Lys Gln Ala Phe His Asn Lys Val Thr Cys Phe Met Leu His His
    290                 295                 300                 
Ile Glu Glu Pro Cys Ser Leu Gly Ala His Ala Ala Val Ile Val Pro
305                 310                 315                 320 
Pro Thr Trp Ile Ile Lys Val Lys Lys Pro Gln Asn Ser Leu Lys Ala
                325                 330                 335     
Ser Asn Arg Lys Lys Lys Arg Thr Ser Phe Lys Arg Lys Ala Ser Lys
            340                 345                 350         
Arg Gly Met Glu Gln Glu Asn Lys Gly Arg Pro Phe Val Ile Lys Pro
        355                 360                 365             
Ile Ser Ser Pro Leu Met Lys Pro Leu Leu Val Phe Val Asn Pro Lys
    370                 375                 380                 
Ser Gly Gly Asn Gln Gly Thr Lys Val Leu Gln Met Phe Met Trp Tyr
385                 390                 395                 400 
Leu Asn Pro Arg Gln Val Phe Asp Leu Ser Gln Glu Gly Pro Lys Asp
                405                 410                 415     
Ala Leu Glu Leu Tyr Arg Lys Val Pro Asn Leu Arg Ile Leu Ala Cys
            420                 425                 430         
Gly Gly Asp Gly Thr Val Gly Trp Ile Leu Ser Ile Leu Asp Glu Leu
        435                 440                 445             
Gln Leu Ser Pro Gln Pro Pro Val Gly Val Leu Pro Leu Gly Thr Gly
    450                 455                 460                 
Asn Asp Leu Ala Arg Thr Leu Asn Trp Gly Gly Gly Tyr Thr Asp Glu
465                 470                 475                 480 
Pro Val Ser Lys Ile Leu Cys Gln Val Glu Asp Gly Thr Val Val Gln
                485                 490                 495     
Leu Asp Arg Trp Asn Leu His Val Glu Arg Asn Pro Asp Leu Pro Pro
            500                 505                 510         
Glu Glu Leu Glu Asp Gly Val Cys Lys Leu Pro Leu Asn Val Phe Asn
        515                 520                 525             
Asn Tyr Phe Ser Leu Gly Phe Asp Ala His Val Thr Leu Glu Phe His
    530                 535                 540                 
Glu Ser Arg Glu Ala Asn Pro Glu Lys Phe Asn Ser Arg Phe Arg Asn
545                 550                 555                 560 
Lys Met Phe Tyr Ala Gly Ala Ala Phe Ser Asp Phe Leu Gln Arg Ser
                565                 570                 575     
Ser Arg Asp Leu Ser Lys His Val Lys Val Val Cys Asp Gly Thr Asp
            580                 585                 590         
Leu Thr Pro Lys Ile Gln Glu Leu Lys Phe Gln Cys Ile Val Phe Leu
        595                 600                 605             
Asn Ile Pro Arg Tyr Cys Ala Gly Thr Met Pro Trp Gly Asn Pro Gly
    610                 615                 620                 
Asp His His Asp Phe Glu Pro Gln Arg His Asp Asp Gly Tyr Ile Glu
625                 630                 635                 640 
Val Ile Gly Phe Thr Met Ala Ser Leu Ala Ala Leu Gln Val Gly Gly
                645                 650                 655     
His Gly Glu Arg Leu His Gln Cys Arg Glu Val Met Leu Leu Thr Tyr
            660                 665                 670         
Lys Ser Ile Pro Met Gln Val Asp Gly Glu Pro Cys Arg Leu Ala Pro
        675                 680                 685             
Ala Met Ile Arg Ile Ser Leu Arg Asn Gln Ala Asn Met Val Gln Lys
    690                 695                 700                 
Ser Lys Arg Arg Thr Ser Met Pro Leu Leu Asn Asp Pro Gln Ser Val
705                 710                 715                 720 
Pro Asp Arg Leu Arg Ile Arg Val Asn Lys Ile Ser Leu Gln Asp Tyr
                725                 730                 735     
Glu Gly Phe His Tyr Asp Lys Glu Lys Leu Arg Glu Ala Ser Ile Ser
            740                 745                 750         
Asp Trp Leu Arg Thr Ile Ala Gly Glu Leu Val Gln Ser Phe Gly Ala
        755                 760                 765             
Ile Pro Leu Gly Ile Leu Val Val Arg Gly Asp Cys Asp Leu Glu Thr
    770                 775                 780                 
Cys Arg Met Tyr Ile Asp Arg Leu Gln Glu Asp Leu Gln Ser Val Ser
785                 790                 795                 800 
Ser Gly Ser Gln Arg Val His Tyr Gln Asp His Glu Thr Ser Phe Pro
                805                 810                 815     
Arg Ala Leu Ser Ala Gln Arg Leu Ser Pro Arg Trp Cys Phe Leu Asp
            820                 825                 830         
Asp Arg Ser Gln Glu His Leu His Phe Val Met Glu Ile Ser Gln Asp
        835                 840                 845             
Glu Ile Phe Ile Leu Asp Pro Asp Met Val Val Ser Gln Pro Ala Gly
    850                 855                 860                 
Thr Pro Pro Gly Met Pro Asp Leu Val Val Glu Gln Ala Ser Gly Ile
865                 870                 875                 880 
Ser Asp Trp Trp Asn Pro Ala Leu Arg Lys Arg Met Leu Ser Asp Ser
                885                 890                 895     
Gly Leu Gly Met Ile Ala Pro Tyr Tyr Glu Asp Ser Asp Leu Lys Asp
            900                 905                 910         
Leu Ser His Ser Arg Val Leu Gln Ser Pro Val Ser Ser Glu Asp His
        915                 920                 925             
Ala Ile Leu Gln Ala Val Ile Ala Gly Asp Leu Met Lys Leu Ile Glu
    930                 935                 940                 
Ser Tyr Lys Asn Gly Gly Ser Leu Leu Ile Gln Gly Pro Asp His Cys
945                 950                 955                 960 
Ser Leu Leu His Tyr Ala Ala Lys Thr Gly Asn Gly Glu Ile Val Lys
                965                 970                 975     
Tyr Ile Leu Asp His Gly Pro Ser Glu Leu Leu Asp Met Ala Asp Ser
            980                 985                 990         
Glu Thr Gly Glu Thr Ala Leu His Lys Ala Ala Cys Gln Arg Asn Arg
        995                 1000                1005            
Ala Val Cys Gln Leu Leu Val Asp Ala Gly Ala Ser Leu Arg Lys Thr
    1010                1015                1020                
Asp Ser Lys Gly Lys Thr Pro Gln Glu Arg Ala Gln Gln Ala Gly Asp
1025                1030                1035                1040
Pro Asp Leu Ala Ala Tyr Leu Glu Ser Arg Gln Asn Tyr Lys Val Ile
                1045                1050                1055    
Gly His Glu Asp Leu Glu Thr Ala Val
            1060                1065


<210> 583
<211> 414
<212> PRT
<213> Homo sapiens

<400> 583
Met Ile Pro Leu Glu Lys Pro Gly Ser Gly Gly Ser Ser Pro Gly Ala
 1               5                  10                  15      
Thr Ser Gly Ser Gly Arg Ala Gly Arg Gly Leu Ser Gly Pro Cys Arg
            20                  25                  30          
Pro Pro Pro Pro Pro Gln Ala Arg Gly Leu Leu Thr Glu Ile Arg Ala
        35                  40                  45              
Val Val Arg Thr Glu Pro Phe Gln Asp Gly Tyr Ser Leu Cys Pro Gly
    50                  55                  60                  
Arg Glu Leu Gly Arg Gly Lys Phe Ala Val Val Arg Lys Cys Ile Lys
65                  70                  75                  80  
Lys Asp Ser Gly Lys Glu Phe Ala Ala Lys Phe Met Arg Lys Arg Arg
                85                  90                  95      
Lys Gly Gln Asp Cys Arg Met Glu Ile Ile His Glu Ile Ala Val Leu
            100                 105                 110         
Glu Leu Ala Gln Asp Asn Pro Trp Val Ile Asn Leu His Glu Val Tyr
        115                 120                 125             
Glu Thr Ala Ser Glu Met Ile Leu Val Leu Glu Tyr Ala Ala Gly Gly
    130                 135                 140                 
Glu Ile Phe Asp Gln Cys Val Ala Asp Arg Glu Glu Ala Phe Lys Glu
145                 150                 155                 160 
Lys Asp Val Gln Arg Leu Met Arg Gln Ile Leu Glu Gly Val His Phe
                165                 170                 175     
Leu His Thr Arg Asp Val Val His Leu Asp Leu Lys Pro Gln Asn Ile
            180                 185                 190         
Leu Leu Thr Ser Glu Ser Pro Leu Gly Asp Ile Lys Ile Val Asp Phe
        195                 200                 205             
Gly Leu Ser Arg Ile Leu Lys Asn Ser Glu Glu Leu Arg Glu Ile Met
    210                 215                 220                 
Gly Thr Pro Glu Tyr Val Ala Pro Glu Ile Leu Ser Tyr Asp Pro Ile
225                 230                 235                 240 
Ser Met Ala Thr Asp Met Trp Ser Ile Gly Val Leu Thr Tyr Val Met
                245                 250                 255     
Leu Thr Gly Ile Ser Pro Phe Leu Gly Asn Asp Lys Gln Glu Thr Phe
            260                 265                 270         
Leu Asn Ile Ser Gln Met Asn Leu Ser Tyr Ser Glu Glu Glu Phe Asp
        275                 280                 285             
Val Leu Ser Glu Ser Ala Val Asp Phe Ile Arg Thr Leu Leu Val Lys
    290                 295                 300                 
Lys Pro Glu Asp Arg Ala Thr Ala Glu Glu Cys Leu Lys His Pro Trp
305                 310                 315                 320 
Leu Thr Gln Ser Ser Ile Gln Glu Pro Ser Phe Arg Met Glu Lys Ala
                325                 330                 335     
Leu Glu Glu Ala Asn Ala Leu Gln Glu Gly His Ser Val Pro Glu Ile
            340                 345                 350         
Asn Ser Asp Thr Asp Lys Ser Glu Thr Glu Glu Ser Ile Val Thr Glu
        355                 360                 365             
Glu Leu Ile Val Val Thr Ser Tyr Thr Leu Gly Gln Cys Arg Gln Ser
    370                 375                 380                 
Glu Lys Glu Lys Met Glu Gln Lys Ala Ile Ser Lys Arg Phe Lys Phe
385                 390                 395                 400 
Glu Glu Pro Leu Leu Gln Glu Ile Pro Gly Glu Phe Ile Tyr
                405                 410                 


<210> 584
<211> 433
<212> PRT
<213> Homo sapiens

<400> 584
Met Cys Leu Arg Gly Gly Cys Ser Pro Arg Ala Pro Ala Ala Ala Pro
 1               5                  10                  15      
Gln Pro Arg Pro Pro Pro Ala Leu Pro Pro Arg Pro Arg Ala Pro Val
            20                  25                  30          
Pro Ala Ser Arg Pro Gly Arg Pro Leu Leu Thr Pro Ala Arg Pro Cys
        35                  40                  45              
Gly Arg Met Arg Arg Gly Ser Pro Gly Pro Arg Leu Gly Gly Ser Arg
    50                  55                  60                  
Gly Glu Arg Arg Arg Pro Ala Gly Arg Asp Pro Ala Arg Val Gly Pro
65                  70                  75                  80  
Gly Gln Gly Leu Arg Arg Pro Ala Arg Pro Gly Pro Ala Ala Trp Thr
                85                  90                  95      
Glu Thr Gly Gln Gly Ile Val His Ala Leu Thr Asp Leu Ser Ile Pro
            100                 105                 110         
Gly Met Thr Ser Gly Asn Gly Asn Ser Ala Ser Ser Ile Ala Gly Thr
        115                 120                 125             
Ala Pro Gln Asn Gly Glu Asn Lys Pro Pro Gln Ala Ile Val Lys Pro
    130                 135                 140                 
Gln Ile Leu Thr His Val Ile Glu Gly Phe Val Ile Gln Glu Gly Ala
145                 150                 155                 160 
Asp Val Ser Arg Trp Asp Ala Arg Leu Leu Val Gly Asn Leu Lys Lys
                165                 170                 175     
Lys Tyr Ala Gln Gly Phe Leu Pro Glu Lys Leu Pro Gln Gln Asp His
            180                 185                 190         
Thr Thr Thr Thr Asp Ser Glu Met Glu Glu Pro Tyr Leu Gln Glu Ser
        195                 200                 205             
Lys Glu Glu Gly Ala Pro Leu Lys Leu Lys Cys Glu Leu Cys Gly Arg
    210                 215                 220                 
Val Asp Phe Ala Tyr Lys Phe Lys Arg Ser Lys Arg Phe Cys Ser Met
225                 230                 235                 240 
Ala Cys Ala Lys Arg Tyr Asn Val Gly Cys Thr Lys Arg Val Gly Leu
                245                 250                 255     
Phe His Ser Asp Arg Ser Lys Leu Gln Lys Ala Gly Ala Ala Thr His
            260                 265                 270         
Asn Arg Arg Arg Pro Ala Lys Pro Val Cys His His Leu Pro Arg Ile
        275                 280                 285             
Pro Arg Ser Ser Gln Gln Ala Leu Cys Pro Phe Arg Leu Leu Leu Leu
    290                 295                 300                 
Cys Val Thr His Ser Gln Glu Asp Ser Ser Arg Cys Ser Asp Asn Ser
305                 310                 315                 320 
Ser Tyr Glu Glu Pro Leu Ser Pro Ile Ser Ala Ser Ser Ser Thr Ser
                325                 330                 335     
Ala Gly Asp Lys Ala Ser Gly Thr Trp Ser Ser Pro Thr Cys Ile Cys
            340                 345                 350         
Gly Thr Trp Trp Ala Trp Asp Thr Thr Ser Cys Gln Val Ser His Gln
        355                 360                 365             
Val Asn Val Glu Asp Val Tyr Glu Phe Ile Arg Ser Leu Pro Gly Cys
    370                 375                 380                 
Gln Glu Ile Ala Glu Glu Phe Arg Ala Gln Glu Ile Asp Gly Gln Ala
385                 390                 395                 400 
Leu Leu Leu Leu Lys Glu Asp His Leu Met Ser Val Met Asn Ile Lys
                405                 410                 415     
Leu Gly Pro Ala Leu Lys Ile Tyr Ala Arg Ile Ser Met Leu Lys Asp
            420                 425                 430         
Ser
    


<210> 585
<211> 617
<212> PRT
<213> Homo sapiens

<400> 585
Met Leu Val Pro Leu Ala Lys Leu Ser Cys Leu Ala Tyr Gln Cys Phe
 1               5                  10                  15      
His Ala Leu Lys Ile Lys Lys Asn Tyr Leu Pro Leu Cys Ala Ile Arg
            20                  25                  30          
Trp Ser Ser Thr Ser Thr Val Pro Arg Ile Thr Thr His Tyr Thr Ile
        35                  40                  45              
Tyr Pro Arg Asp Lys Asp Lys Arg Trp Glu Gly Val Asn Met Glu Arg
    50                  55                  60                  
Phe Ala Glu Glu Ala Asp Val Val Ile Val Gly Ala Gly Pro Ala Gly
65                  70                  75                  80  
Leu Ser Ala Ala Val Arg Leu Lys Gln Leu Ala Val Ala His Glu Lys
                85                  90                  95      
Asp Ile Arg Val Cys Leu Val Glu Lys Ala Ala Gln Ile Gly Ala His
            100                 105                 110         
Thr Leu Ser Gly Ala Cys Leu Asp Pro Gly Ala Phe Lys Glu Leu Phe
        115                 120                 125             
Pro Asp Trp Lys Glu Lys Gly Ala Pro Leu Asn Thr Pro Val Thr Glu
    130                 135                 140                 
Asp Arg Phe Gly Ile Leu Thr Glu Lys Tyr Arg Ile Pro Val Pro Ile
145                 150                 155                 160 
Leu Pro Gly Leu Pro Met Asn Asn His Gly Asn Tyr Ile Val Arg Leu
                165                 170                 175     
Gly His Leu Val Ser Trp Met Gly Glu Gln Ala Glu Ala Leu Gly Val
            180                 185                 190         
Glu Val Tyr Pro Gly Tyr Ala Ala Ala Glu Val Leu Phe His Asp Asp
        195                 200                 205             
Gly Ser Val Lys Gly Ile Ala Thr Asn Asp Val Gly Ile Gln Lys Asp
    210                 215                 220                 
Gly Ala Pro Lys Ala Thr Phe Glu Arg Gly Leu Glu Leu His Ala Lys
225                 230                 235                 240 
Val Thr Ile Phe Ala Glu Gly Cys His Gly His Leu Ala Lys Gln Leu
                245                 250                 255     
Tyr Lys Lys Phe Asp Leu Arg Ala Asn Cys Glu Pro Gln Thr Tyr Gly
            260                 265                 270         
Ile Gly Leu Lys Glu Leu Trp Val Ile Asp Glu Lys Asn Trp Lys Pro
        275                 280                 285             
Gly Arg Val Asp His Thr Val Gly Trp Pro Leu Asp Arg His Thr Tyr
    290                 295                 300                 
Gly Gly Ser Phe Leu Tyr His Leu Asn Glu Gly Glu Pro Leu Val Ala
305                 310                 315                 320 
Leu Gly Leu Val Val Gly Leu Asp Tyr Gln Asn Pro Tyr Leu Ser Pro
                325                 330                 335     
Phe Arg Glu Phe Gln Arg Trp Lys His His Pro Ser Ile Arg Pro Thr
            340                 345                 350         
Leu Glu Gly Gly Lys Arg Ile Ala Tyr Gly Ala Arg Ala Leu Asn Glu
        355                 360                 365             
Gly Gly Phe Gln Ser Ile Pro Lys Leu Thr Phe Pro Gly Gly Leu Leu
    370                 375                 380                 
Ile Gly Cys Ser Pro Gly Phe Met Asn Val Pro Lys Ile Lys Gly Thr
385                 390                 395                 400 
His Thr Ala Met Lys Ser Gly Ile Leu Ala Ala Glu Ser Ile Phe Asn
                405                 410                 415     
Gln Leu Thr Ser Glu Asn Leu Gln Ser Lys Thr Ile Gly Leu His Val
            420                 425                 430         
Thr Glu Tyr Glu Asp Asn Leu Lys Asn Ser Trp Val Trp Lys Glu Leu
        435                 440                 445             
Tyr Ser Val Arg Asn Ile Arg Pro Ser Cys His Gly Val Leu Gly Val
    450                 455                 460                 
Tyr Gly Gly Met Ile Tyr Thr Gly Ile Phe Tyr Trp Ile Leu Arg Gly
465                 470                 475                 480 
Met Glu Pro Trp Thr Leu Lys His Lys Gly Ser Asp Phe Glu Arg Leu
                485                 490                 495     
Lys Pro Ala Lys Asp Cys Thr Pro Ile Glu Tyr Pro Lys Pro Asp Gly
            500                 505                 510         
Gln Ile Ser Phe Asp Leu Leu Ser Ser Val Ala Leu Ser Gly Thr Asn
        515                 520                 525             
His Glu His Asp Gln Pro Ala His Leu Thr Leu Arg Asp Asp Ser Ile
    530                 535                 540                 
Pro Val Asn Arg Asn Leu Ser Ile Tyr Asp Gly Pro Glu Gln Arg Phe
545                 550                 555                 560 
Cys Pro Ala Gly Val Tyr Glu Phe Val Pro Val Glu Gln Gly Asp Gly
                565                 570                 575     
Phe Arg Leu Gln Ile Asn Ala Gln Asn Cys Val His Cys Lys Thr Cys
            580                 585                 590         
Asp Ile Lys Asp Pro Ser Gln Asn Ile Asn Trp Val Val Pro Glu Gly
        595                 600                 605             
Gly Gly Gly Pro Ala Tyr Asn Gly Met
    610                 615         


<210> 586
<211> 184
<212> PRT
<213> Homo sapiens

<400> 586
Met Ala Ala Ala Gly Gly Ala Arg Leu Leu Arg Ala Ala Ser Ala Val
 1               5                  10                  15      
Leu Gly Gly Pro Ala Gly Arg Trp Leu His His Ala Gly Ser Arg Ala
            20                  25                  30          
Gly Ser Ser Gly Leu Leu Arg Asn Arg Gly Pro Gly Gly Ser Ala Glu
        35                  40                  45              
Ala Ser Arg Ser Leu Ser Val Ser Ala Arg Ala Arg Ser Ser Ser Glu
    50                  55                  60                  
Asp Lys Ile Thr Val His Phe Ile Asn Arg Asp Gly Glu Thr Leu Thr
65                  70                  75                  80  
Thr Lys Gly Lys Val Gly Asp Ser Leu Leu Asp Val Val Val Glu Asn
                85                  90                  95      
Asn Leu Asp Ile Asp Gly Phe Gly Ala Cys Glu Gly Thr Leu Ala Cys
            100                 105                 110         
Ser Thr Cys His Leu Ile Phe Glu Asp His Ile Tyr Glu Lys Leu Asp
        115                 120                 125             
Ala Ile Thr Asp Glu Glu Asn Asp Met Leu Asp Leu Ala Tyr Gly Leu
    130                 135                 140                 
Thr Asp Arg Ser Arg Leu Gly Cys Gln Ile Cys Leu Thr Lys Ser Met
145                 150                 155                 160 
Asp Asn Met Thr Val Arg Val Pro Glu Thr Val Ala Asp Ala Arg Gln
                165                 170                 175     
Ser Ile Asp Val Gly Lys Thr Ser
            180                 


<210> 587
<211> 584
<212> PRT
<213> Homo sapiens

<400> 587
Met Asp Glu Gly Cys Gly Glu Thr Ile Tyr Val Ile Gly Gln Gly Ser
 1               5                  10                  15      
Asp Gly Thr Glu Tyr Gly Leu Ser Glu Ala Asp Met Glu Ala Ser Tyr
            20                  25                  30          
Ala Thr Val Lys Ser Met Ala Glu Gln Ile Glu Ala Asp Val Ile Leu
        35                  40                  45              
Leu Arg Glu Arg Gln Glu Ala Gly Gly Arg Val Arg Asp Tyr Leu Val
    50                  55                  60                  
Arg Lys Arg Val Gly Asp Asn Asp Phe Leu Glu Val Arg Val Ala Val
65                  70                  75                  80  
Val Gly Asn Val Asp Ala Gly Lys Ser Thr Leu Leu Gly Val Leu Thr
                85                  90                  95      
His Gly Glu Leu Asp Asn Gly Arg Gly Phe Ala Arg Gln Lys Leu Phe
            100                 105                 110         
Arg His Lys His Glu Ile Glu Ser Gly Arg Thr Ser Ser Val Gly Asn
        115                 120                 125             
Asp Ile Leu Gly Phe Asp Ser Glu Gly Asn Val Val Asn Lys Pro Asp
    130                 135                 140                 
Ser His Gly Gly Ser Leu Glu Trp Thr Lys Ile Cys Glu Lys Ser Thr
145                 150                 155                 160 
Lys Val Ile Thr Phe Ile Asp Leu Ala Gly His Glu Lys Tyr Leu Lys
                165                 170                 175     
Thr Thr Val Phe Gly Met Thr Gly His Leu Pro Asp Phe Cys Met Leu
            180                 185                 190         
Met Val Gly Ser Asn Ala Gly Ile Val Gly Met Thr Lys Glu His Leu
        195                 200                 205             
Gly Leu Ala Leu Ala Leu Asn Val Pro Val Phe Val Val Val Thr Lys
    210                 215                 220                 
Ile Asp Met Cys Pro Ala Asn Ile Leu Gln Glu Thr Leu Lys Leu Leu
225                 230                 235                 240 
Gln Arg Leu Leu Lys Ser Pro Gly Cys Arg Lys Ile Pro Val Leu Val
                245                 250                 255     
Gln Ser Lys Asp Asp Val Ile Val Thr Ala Ser Asn Phe Ser Ser Glu
            260                 265                 270         
Arg Met Cys Pro Ile Phe Gln Ile Ser Asn Val Thr Gly Glu Asn Leu
        275                 280                 285             
Asp Leu Leu Lys Met Phe Leu Asn Leu Leu Ser Pro Arg Thr Ser Tyr
    290                 295                 300                 
Arg Glu Glu Glu Pro Ala Glu Phe Gln Ile Asp Asp Thr Tyr Ser Val
305                 310                 315                 320 
Pro Gly Val Gly Thr Val Val Ser Gly Thr Thr Leu Arg Gly Leu Ile
                325                 330                 335     
Lys Leu Asn Asp Thr Leu Leu Leu Gly Pro Asp Pro Leu Gly Asn Phe
            340                 345                 350         
Leu Ser Ile Ala Val Lys Ser Ile His Arg Lys Arg Met Pro Val Lys
        355                 360                 365             
Glu Val Arg Gly Gly Gln Thr Ala Ser Phe Ala Leu Lys Lys Ile Lys
    370                 375                 380                 
Arg Ser Ser Ile Arg Lys Gly Met Val Met Val Ser Pro Arg Leu Asn
385                 390                 395                 400 
Pro Gln Ala Ser Trp Glu Phe Glu Ala Glu Ile Leu Val Leu His His
                405                 410                 415     
Pro Thr Thr Ile Ser Pro Arg Tyr Gln Ala Met Val His Cys Gly Ser
            420                 425                 430         
Ile Arg Gln Thr Ala Thr Ile Leu Ser Met Asp Lys Asp Cys Leu Arg
        435                 440                 445             
Thr Gly Asp Lys Ala Thr Val His Phe Arg Phe Ile Lys Thr Pro Glu
    450                 455                 460                 
Tyr Leu His Ile Asp Gln Arg Leu Val Phe Arg Glu Gly Arg Thr Lys
465                 470                 475                 480 
Ala Val Gly Thr Ile Thr Lys Leu Leu Gln Thr Thr Asn Asn Ser Pro
                485                 490                 495     
Met Asn Ser Lys Pro Gln Gln Ile Lys Met Gln Ser Thr Lys Lys Gly
            500                 505                 510         
Pro Leu Thr Lys Arg Asp Glu Gly Gly Pro Ser Gly Gly Pro Ala Val
        515                 520                 525             
Gly Ala Pro Pro Pro Gly Asp Glu Ala Ser Ser Val Gly Ala Gly Gln
    530                 535                 540                 
Pro Ala Ala Ser Ser Asn Leu Gln Pro Gln Pro Lys Pro Ser Ser Gly
545                 550                 555                 560 
Gly Arg Arg Arg Gly Gly Gln Arg His Lys Val Lys Ser Gln Gly Ala
                565                 570                 575     
Cys Val Thr Pro Ala Ser Gly Cys
            580                 


<210> 588
<211> 791
<212> PRT
<213> Homo sapiens

<400> 588
Met Trp Asn Met Leu Ile Val Ala Met Cys Leu Ala Leu Leu Gly Cys
 1               5                  10                  15      
Leu Gln Ala Gln Glu Leu Gln Gly His Val Ser Ile Ile Leu Leu Gly
            20                  25                  30          
Ala Thr Gly Asp Leu Ala Lys Lys Tyr Leu Trp Gln Gly Leu Phe Gln
        35                  40                  45              
Leu Tyr Leu Asp Glu Ala Gly Arg Gly His Ser Phe Ser Phe His Gly
    50                  55                  60                  
Ala Ala Leu Thr Ala Pro Lys Gln Gly Gln Glu Leu Met Ala Lys Ala
65                  70                  75                  80  
Leu Glu Ser Leu Ser Cys Pro Lys Asp Met Ala Pro Ser His Cys Ala
                85                  90                  95      
Glu His Lys Asp Gln Phe Leu Gln Leu Ser Gln Tyr Arg Gln Leu Lys
            100                 105                 110         
Thr Ala Glu Asp Tyr Gln Ala Leu Asn Lys Asp Ile Glu Ala Gln Leu
        115                 120                 125             
Gln His Ala Gly Leu Arg Glu Ala Gly Arg Ile Phe Tyr Phe Ser Val
    130                 135                 140                 
Pro Pro Phe Ala Tyr Glu Asp Ile Ala Arg Asn Ile Asn Ser Ser Cys
145                 150                 155                 160 
Arg Pro Gly Pro Gly Ala Trp Leu Arg Val Val Leu Glu Lys Pro Phe
                165                 170                 175     
Gly His Asp His Phe Ser Ala Gln Gln Leu Ala Thr Glu Leu Gly Thr
            180                 185                 190         
Phe Phe Gln Glu Glu Glu Met Tyr Arg Val Asp His Tyr Leu Gly Lys
        195                 200                 205             
Gln Ala Val Ala Gln Ile Leu Pro Phe Arg Asp Gln Asn Arg Lys Ala
    210                 215                 220                 
Leu Asp Gly Leu Trp Asn Arg His His Val Glu Arg Val Glu Ile Ile
225                 230                 235                 240 
Met Lys Glu Thr Val Asp Ala Glu Gly Arg Thr Ser Phe Tyr Glu Glu
                245                 250                 255     
Tyr Gly Val Ile Arg Asp Val Leu Gln Asn His Leu Thr Glu Val Leu
            260                 265                 270         
Thr Leu Val Ala Met Glu Leu Pro His Asn Val Ser Ser Ala Glu Ala
        275                 280                 285             
Val Leu Arg His Lys Leu Gln Val Phe Gln Ala Leu Arg Gly Leu Gln
    290                 295                 300                 
Arg Gly Ser Ala Val Val Gly Gln Tyr Gln Ser Tyr Ser Glu Gln Val
305                 310                 315                 320 
Arg Arg Glu Leu Gln Lys Pro Asp Ser Phe His Ser Leu Thr Pro Thr
                325                 330                 335     
Phe Ala Gly Val Leu Val His Ile Asp Asn Leu Arg Trp Glu Gly Val
            340                 345                 350         
Pro Phe Ile Leu Met Ser Gly Lys Ala Leu Asp Glu Arg Val Gly Tyr
        355                 360                 365             
Ala Arg Ile Leu Phe Lys Asn Gln Ala Cys Cys Val Gln Ser Glu Lys
    370                 375                 380                 
His Trp Ala Ala Ala Gln Ser Gln Cys Leu Pro Arg Gln Leu Val Phe
385                 390                 395                 400 
His Ile Gly His Gly Asp Leu Gly Ser Pro Ala Val Leu Val Ser Arg
                405                 410                 415     
Asn Leu Phe Arg Pro Ser Leu Pro Ser Ser Trp Lys Glu Met Glu Gly
            420                 425                 430         
Pro Pro Gly Leu Arg Leu Phe Gly Ser Pro Leu Ser Asp Tyr Tyr Ala
        435                 440                 445             
Tyr Ser Pro Val Arg Glu Arg Asp Ala His Ser Val Leu Leu Ser His
    450                 455                 460                 
Ile Phe His Gly Arg Lys Asn Phe Phe Ile Thr Thr Glu Asn Leu Leu
465                 470                 475                 480 
Ala Ser Trp Asn Phe Trp Thr Pro Leu Leu Glu Ser Leu Ala His Lys
                485                 490                 495     
Ala Pro Arg Leu Tyr Pro Gly Gly Ala Glu Asn Gly Arg Leu Leu Asp
            500                 505                 510         
Phe Glu Phe Ser Ser Gly Arg Leu Phe Phe Ser Gln Gln Gln Pro Glu
        515                 520                 525             
Gln Leu Val Pro Gly Pro Gly Pro Ala Pro Met Pro Ser Asp Phe Gln
    530                 535                 540                 
Val Leu Arg Ala Lys Tyr Arg Glu Ser Pro Leu Val Ser Ala Trp Ser
545                 550                 555                 560 
Glu Glu Leu Ile Ser Lys Leu Ala Asn Asp Ile Glu Ala Thr Ala Val
                565                 570                 575     
Arg Ala Val Arg Arg Phe Gly Gln Phe His Leu Ala Leu Ser Gly Gly
            580                 585                 590         
Ser Ser Pro Val Ala Leu Phe Gln Gln Leu Ala Thr Ala His Tyr Gly
        595                 600                 605             
Phe Pro Trp Ala His Thr His Leu Trp Leu Val Asp Glu Arg Cys Val
    610                 615                 620                 
Pro Leu Ser Asp Pro Glu Ser Asn Phe Gln Gly Leu Gln Ala His Leu
625                 630                 635                 640 
Leu Gln His Val Arg Ile Pro Tyr Tyr Asn Ile His Pro Met Pro Val
                645                 650                 655     
His Leu Gln Gln Arg Leu Cys Ala Glu Glu Asp Gln Gly Ala Gln Ile
            660                 665                 670         
Tyr Ala Arg Glu Ile Ser Ala Leu Val Ala Asn Ser Ser Phe Asp Leu
        675                 680                 685             
Val Leu Leu Gly Met Gly Ala Asp Gly His Thr Ala Ser Leu Phe Pro
    690                 695                 700                 
Gln Ser Pro Thr Gly Leu Asp Gly Glu Gln Leu Val Val Leu Thr Thr
705                 710                 715                 720 
Ser Pro Ser Gln Pro His Arg Arg Met Ser Leu Ser Leu Pro Leu Ile
                725                 730                 735     
Asn Arg Ala Lys Lys Val Ala Val Leu Val Met Gly Arg Met Lys Arg
            740                 745                 750         
Glu Ile Thr Thr Leu Val Ser Arg Val Gly His Glu Pro Lys Lys Trp
        755                 760                 765             
Pro Ile Ser Gly Val Leu Pro His Ser Gly Gln Leu Val Trp Tyr Met
    770                 775                 780                 
Asp Tyr Asp Ala Phe Leu Gly
785                 790     


<210> 589
<211> 261
<212> PRT
<213> Homo sapiens

<400> 589
Met Ala Ala Ala Cys Arg Ser Val Lys Gly Leu Val Ala Val Ile Thr
 1               5                  10                  15      
Gly Gly Ala Ser Gly Leu Gly Leu Ala Thr Ala Glu Arg Leu Val Gly
            20                  25                  30          
Gln Gly Ala Ser Ala Val Leu Leu Asp Leu Pro Asn Ser Gly Gly Glu
        35                  40                  45              
Ala Gln Ala Lys Lys Leu Gly Asn Asn Cys Val Phe Ala Pro Ala Asp
    50                  55                  60                  
Val Thr Ser Glu Lys Asp Val Gln Thr Ala Leu Ala Leu Ala Lys Gly
65                  70                  75                  80  
Lys Phe Gly Arg Val Asp Val Ala Val Asn Cys Ala Gly Ile Ala Val
                85                  90                  95      
Ala Ser Lys Thr Tyr Asn Leu Lys Lys Gly Gln Thr His Thr Leu Glu
            100                 105                 110         
Asp Phe Gln Arg Val Leu Asp Val Asn Leu Met Gly Thr Phe Asn Val
        115                 120                 125             
Ile Arg Leu Val Ala Gly Glu Met Gly Gln Asn Glu Pro Asp Gln Gly
    130                 135                 140                 
Gly Gln Arg Gly Val Ile Ile Asn Thr Ala Ser Val Ala Ala Phe Glu
145                 150                 155                 160 
Gly Gln Val Gly Gln Ala Ala Tyr Ser Ala Ser Lys Gly Gly Ile Val
                165                 170                 175     
Gly Met Thr Leu Pro Ile Ala Arg Asp Leu Ala Pro Ile Gly Ile Arg
            180                 185                 190         
Val Met Thr Ile Ala Pro Gly Leu Phe Gly Thr Pro Leu Leu Thr Ser
        195                 200                 205             
Leu Pro Glu Lys Val Cys Asn Phe Leu Ala Ser Gln Val Pro Phe Pro
    210                 215                 220                 
Ser Arg Leu Gly Asp Pro Ala Glu Tyr Ala His Leu Val Gln Ala Ile
225                 230                 235                 240 
Ile Glu Asn Pro Phe Leu Asn Gly Glu Val Ile Arg Leu Asp Gly Ala
                245                 250                 255     
Ile Arg Met Gln Pro
            260     


<210> 590
<211> 4834
<212> PRT
<213> Homo sapiens

<400> 590
Met Pro Ser Glu Ser Phe Cys Leu Ala Ala Gln Ala Arg Leu Asp Ser
 1               5                  10                  15      
Lys Trp Leu Lys Thr Asp Ile Gln Leu Ala Phe Thr Arg Asp Gly Leu
            20                  25                  30          
Cys Gly Leu Trp Asn Glu Met Val Lys Asp Gly Glu Ile Val Tyr Thr
        35                  40                  45              
Gly Thr Glu Ser Thr Gln Asn Gly Glu Leu Pro Pro Arg Lys Asp Asp
    50                  55                  60                  
Ser Val Glu Pro Ser Gly Thr Lys Lys Glu Asp Leu Asn Asp Lys Glu
65                  70                  75                  80  
Lys Lys Asp Glu Glu Glu Thr Pro Ala Pro Ile Tyr Arg Ala Lys Ser
                85                  90                  95      
Ile Leu Asp Ser Trp Val Trp Gly Lys Gln Pro Asp Val Asn Glu Leu
            100                 105                 110         
Lys Glu Cys Leu Ser Val Leu Val Lys Glu Gln Gln Ala Leu Ala Val
        115                 120                 125             
Gln Ser Ala Thr Thr Thr Leu Ser Ala Leu Arg Leu Lys Gln Arg Leu
    130                 135                 140                 
Val Ile Leu Glu Arg Tyr Phe Ile Ala Leu Asn Arg Thr Val Phe Gln
145                 150                 155                 160 
Glu Asn Val Lys Val Lys Trp Lys Ser Ser Gly Ile Ser Leu Pro Pro
                165                 170                 175     
Val Asp Lys Lys Ser Ser Arg Pro Ala Gly Lys Gly Val Glu Gly Leu
            180                 185                 190         
Ala Arg Val Gly Ser Arg Ala Ala Leu Ser Phe Ala Phe Ala Phe Leu
        195                 200                 205             
Arg Arg Ala Trp Arg Ser Gly Glu Asp Ala Asp Leu Cys Ser Glu Leu
    210                 215                 220                 
Leu Gln Glu Ser Leu Asp Ala Leu Arg Ala Leu Pro Glu Ala Ser Leu
225                 230                 235                 240 
Phe Asp Glu Ser Thr Val Ser Ser Val Trp Leu Glu Val Val Glu Arg
                245                 250                 255     
Ala Thr Arg Phe Leu Arg Ser Val Val Thr Gly Asp Val His Gly Thr
            260                 265                 270         
Pro Ala Thr Lys Gly Pro Gly Ser Ile Pro Leu Gln Asp Gln His Leu
        275                 280                 285             
Ala Leu Ala Ile Leu Leu Glu Leu Ala Val Gln Arg Gly Thr Leu Ser
    290                 295                 300                 
Gln Met Leu Ser Ala Ile Leu Leu Leu Leu Gln Leu Trp Asp Ser Gly
305                 310                 315                 320 
Ala Gln Glu Thr Asp Asn Glu Arg Ser Ala Gln Gly Thr Ser Ala Pro
                325                 330                 335     
Leu Leu Pro Leu Leu Gln Arg Phe Gln Ser Ile Ile Cys Arg Lys Asp
            340                 345                 350         
Ala Pro His Ser Glu Gly Asp Met His Leu Leu Ser Gly Pro Leu Ser
        355                 360                 365             
Pro Asn Glu Ser Phe Leu Arg Tyr Leu Thr Leu Pro Gln Asp Asn Glu
    370                 375                 380                 
Leu Ala Ile Asp Leu Arg Gln Thr Ala Val Val Val Met Ala His Leu
385                 390                 395                 400 
Asp Arg Leu Ala Thr Pro Cys Met Pro Pro Leu Cys Ser Ser Pro Thr
                405                 410                 415     
Ser His Lys Gly Ser Leu Gln Glu Val Ile Gly Trp Gly Leu Ile Gly
            420                 425                 430         
Trp Lys Tyr Tyr Ala Asn Val Ile Gly Pro Ile Gln Cys Glu Gly Leu
        435                 440                 445             
Ala Asn Leu Gly Val Thr Gln Ile Ala Cys Ala Glu Lys Arg Phe Leu
    450                 455                 460                 
Ile Leu Ser Arg Asn Gly Arg Val Tyr Thr Gln Ala Tyr Asn Ser Asp
465                 470                 475                 480 
Thr Leu Ala Pro Gln Leu Val Gln Gly Leu Ala Ser Arg Asn Ile Val
                485                 490                 495     
Lys Ile Ala Ala His Ser Asp Gly His His Tyr Leu Ala Leu Ala Ala
            500                 505                 510         
Thr Gly Glu Val Tyr Ser Trp Gly Cys Gly Asp Gly Gly Arg Leu Gly
        515                 520                 525             
His Gly Asp Thr Val Pro Leu Glu Glu Pro Lys Val Ile Ser Ala Phe
    530                 535                 540                 
Ser Gly Lys Gln Ala Gly Lys His Val Val His Ile Ala Cys Gly Ser
545                 550                 555                 560 
Thr Tyr Ser Ala Ala Ile Thr Ala Glu Gly Glu Leu Tyr Thr Trp Gly
                565                 570                 575     
Arg Gly Asn Tyr Gly Arg Leu Gly His Gly Ser Ser Glu Asp Glu Ala
            580                 585                 590         
Ile Pro Met Leu Val Ala Gly Leu Lys Gly Leu Lys Val Ile Asp Val
        595                 600                 605             
Ala Cys Gly Ser Gly Asp Ala Gln Thr Leu Ala Val Thr Glu Asn Gly
    610                 615                 620                 
Gln Val Trp Ser Trp Gly Asp Gly Asp Tyr Gly Lys Leu Gly Arg Gly
625                 630                 635                 640 
Gly Ser Asp Gly Cys Lys Thr Pro Lys Leu Ile Glu Lys Leu Gln Asp
                645                 650                 655     
Leu Asp Val Val Lys Val Arg Cys Gly Ser Gln Phe Ser Ile Ala Leu
            660                 665                 670         
Thr Lys Asp Gly Gln Val Tyr Ser Trp Gly Lys Gly Asp Asn Gln Arg
        675                 680                 685             
Leu Gly His Gly Thr Glu Glu His Val Arg Tyr Pro Lys Leu Leu Glu
    690                 695                 700                 
Gly Leu Gln Gly Lys Lys Val Ile Asp Val Ala Ala Gly Ser Thr His
705                 710                 715                 720 
Cys Leu Ala Leu Thr Glu Asp Ser Glu Val His Ser Trp Gly Ser Asn
                725                 730                 735     
Asp Gln Cys Gln His Phe Asp Thr Leu Arg Val Thr Lys Pro Glu Pro
            740                 745                 750         
Ala Ala Leu Pro Gly Leu Asp Thr Lys His Ile Val Gly Ile Ala Cys
        755                 760                 765             
Gly Pro Ala Gln Ser Phe Ala Trp Ser Ser Cys Ser Glu Trp Ser Ile
    770                 775                 780                 
Gly Leu Arg Val Pro Phe Val Val Asp Ile Cys Ser Met Thr Phe Glu
785                 790                 795                 800 
Gln Leu Asp Leu Leu Leu Arg Gln Val Ser Glu Gly Met Asp Gly Ser
                805                 810                 815     
Ala Asp Trp Pro Pro Pro Gln Glu Lys Glu Cys Val Ala Val Ala Thr
            820                 825                 830         
Leu Asn Leu Leu Arg Leu Gln Leu His Ala Ala Ile Ser His Gln Val
        835                 840                 845             
Asp Pro Glu Phe Leu Gly Leu Gly Leu Gly Ser Ile Leu Leu Asn Ser
    850                 855                 860                 
Leu Lys Gln Thr Val Val Thr Leu Ala Ser Ser Ala Gly Val Leu Ser
865                 870                 875                 880 
Thr Val Gln Ser Ala Ala Gln Ala Val Leu Gln Ser Gly Trp Ser Val
                885                 890                 895     
Leu Leu Pro Thr Ala Glu Glu Arg Ala Arg Ala Leu Ser Ala Leu Leu
            900                 905                 910         
Pro Cys Ala Val Ser Gly Asn Glu Val Asn Ile Ser Pro Gly Arg Arg
        915                 920                 925             
Phe Met Ile Asp Leu Leu Val Gly Ser Leu Met Ala Asp Gly Gly Leu
    930                 935                 940                 
Glu Ser Ala Leu His Ala Ala Ile Thr Ala Glu Ile Gln Asp Ile Glu
945                 950                 955                 960 
Ala Lys Lys Glu Ala Gln Lys Glu Lys Glu Ile Asp Glu Gln Glu Ala
                965                 970                 975     
Asn Ala Ser Thr Phe His Arg Ser Arg Thr Pro Leu Asp Lys Asp Leu
            980                 985                 990         
Ile Asn Thr Gly Ile Cys Glu Ser Ser Gly Lys Gln Cys Leu Pro Leu
        995                 1000                1005            
Val Gln Leu Ile Gln Gln Leu Leu Arg Asn Ile Ala Ser Gln Thr Val
    1010                1015                1020                
Ala Arg Leu Lys Asp Val Ala Arg Arg Ile Ser Ser Cys Leu Asp Phe
1025                1030                1035                1040
Glu Gln His Ser Arg Glu Arg Ser Ala Ser Leu Asp Trp Leu Leu Arg
                1045                1050                1055    
Phe Gln Arg Leu Leu Ile Ser Lys Leu Tyr Pro Gly Glu Ser Ile Gly
            1060                1065                1070        
Gln Thr Ser Asp Ile Ser Ser Pro Glu Leu Met Gly Val Gly Ser Leu
        1075                1080                1085            
Leu Lys Lys Tyr Thr Ala Leu Leu Cys Thr His Ile Gly Asp Ile Leu
    1090                1095                1100                
Pro Val Ala Ala Ser Ile Ala Ser Thr Ser Trp Arg His Phe Ala Glu
1105                1110                1115                1120
Val Ala Tyr Ile Val Glu Gly Asp Phe Thr Gly Val Leu Leu Pro Glu
                1125                1130                1135    
Leu Val Val Ser Ile Val Leu Leu Leu Ser Lys Asn Ala Asp Leu Met
            1140                1145                1150        
Gln Glu Ala Gly Ala Val Pro Leu Leu Gly Gly Leu Leu Glu His Leu
        1155                1160                1165            
Asp Arg Phe Asn His Leu Ala Pro Gly Lys Glu Arg Asp Asp His Glu
    1170                1175                1180                
Glu Leu Ala Trp Pro Gly Ile Met Glu Ser Phe Phe Thr Gly Gln Asn
1185                1190                1195                1200
Cys Arg Asn Asn Glu Glu Val Thr Leu Ile Arg Lys Ala Asp Leu Glu
                1205                1210                1215    
Asn His Asn Lys Asp Gly Gly Phe Trp Thr Val Ile Asp Gly Lys Val
            1220                1225                1230        
Tyr Asp Ile Lys Asp Phe Gln Thr Gln Ser Leu Thr Gly Asn Ser Ile
        1235                1240                1245            
Leu Ala Gln Phe Ala Gly Glu Asp Pro Val Val Ala Leu Glu Ala Ala
    1250                1255                1260                
Leu Gln Phe Glu Asp Thr Arg Glu Ser Met His Ala Phe Cys Val Gly
1265                1270                1275                1280
Gln Tyr Leu Glu Pro Asp Gln Glu Ile Val Thr Ile Pro Asp Leu Gly
                1285                1290                1295    
Ser Leu Ser Ser Pro Leu Ile Asp Thr Glu Arg Asn Leu Gly Leu Leu
            1300                1305                1310        
Leu Gly Leu His Ala Ser Tyr Leu Ala Met Ser Thr Pro Leu Ser Pro
        1315                1320                1325            
Val Glu Ile Glu Cys Ala Lys Trp Leu Gln Ser Ser Ile Phe Ser Gly
    1330                1335                1340                
Gly Leu Gln Thr Ser Gln Ile His Tyr Arg Tyr Asn Glu Glu Lys Asp
1345                1350                1355                1360
Glu Asp His Cys Ser Ser Pro Gly Gly Thr Pro Ala Ser Lys Ser Arg
                1365                1370                1375    
Leu Cys Ser His Arg Arg Ala Leu Gly Asp His Ser Gln Ala Phe Leu
            1380                1385                1390        
Gln Ala Ile Ala Asp Asn Asn Ile Gln Asp His Asn Val Lys Asp Phe
        1395                1400                1405            
Leu Cys Gln Ile Glu Arg Tyr Cys Arg Gln Cys His Leu Thr Thr Pro
    1410                1415                1420                
Ile Met Phe Pro Pro Glu His Pro Val Glu Glu Val Gly Arg Leu Leu
1425                1430                1435                1440
Leu Cys Cys Leu Leu Lys His Glu Asp Leu Gly His Val Ala Leu Ser
                1445                1450                1455    
Leu Val His Ala Gly Ala Leu Gly Ile Glu Gln Val Lys His Arg Thr
            1460                1465                1470        
Leu Pro Lys Ser Val Val Asp Val Cys Arg Val Val Tyr Gln Ala Lys
        1475                1480                1485            
Cys Ser Leu Ile Lys Thr His Gln Glu Gln Gly Arg Ser Tyr Lys Glu
    1490                1495                1500                
Val Cys Ala Pro Val Ile Glu Arg Leu Arg Phe Leu Phe Asn Glu Leu
1505                1510                1515                1520
Arg Pro Ala Val Cys Asn Asp Leu Ser Ile Met Ser Lys Phe Lys Leu
                1525                1530                1535    
Leu Ser Ser Leu Pro Arg Trp Arg Arg Ile Ala Gln Lys Ile Ile Arg
            1540                1545                1550        
Glu Arg Arg Lys Lys Arg Val Pro Lys Lys Pro Glu Ser Met Asp Asp
        1555                1560                1565            
Glu Glu Lys Ile Gly Asn Glu Glu Ser Asp Leu Glu Glu Ala Cys Ile
    1570                1575                1580                
Leu Pro His Ser Pro Ile Asn Val Asp Lys Arg Pro Ile Ala Ile Lys
1585                1590                1595                1600
Ser Pro Lys Asp Lys Trp Gln Pro Leu Leu Ser Thr Val Thr Gly Val
                1605                1610                1615    
His Lys Tyr Lys Trp Leu Lys Gln Asn Val Gln Gly Leu Tyr Pro Gln
            1620                1625                1630        
Ser Pro Leu Leu Ser Thr Ile Ala Glu Phe Ala Leu Lys Glu Glu Pro
        1635                1640                1645            
Val Asp Val Glu Lys Met Arg Lys Cys Leu Leu Lys Gln Leu Glu Arg
    1650                1655                1660                
Ala Glu Val Arg Leu Glu Gly Ile Asp Thr Ile Leu Lys Leu Ala Ser
1665                1670                1675                1680
Lys Asn Phe Leu Leu Pro Ser Val Gln Tyr Ala Met Phe Cys Gly Trp
                1685                1690                1695    
Gln Arg Leu Ile Pro Glu Gly Ile Asp Ile Gly Glu Pro Leu Thr Asp
            1700                1705                1710        
Cys Leu Lys Asp Val Asp Leu Ile Pro Pro Phe Asn Arg Met Leu Leu
        1715                1720                1725            
Glu Val Thr Phe Gly Lys Leu Tyr Ala Trp Ala Val Gln Asn Ile Arg
    1730                1735                1740                
Asn Val Leu Met Asp Ala Ser Ala Thr Phe Lys Glu Leu Gly Ile Gln
1745                1750                1755                1760
Pro Val Pro Leu Gln Thr Ile Thr Asn Glu Asn Pro Ser Gly Pro Ser
                1765                1770                1775    
Leu Gly Thr Ile Pro Gln Ala Arg Phe Leu Leu Val Met Leu Ser Met
            1780                1785                1790        
Leu Thr Leu Gln His Gly Ala Asn Asn Leu Asp Leu Leu Leu Asn Ser
        1795                1800                1805            
Gly Met Leu Ala Leu Thr Gln Thr Ala Leu Arg Leu Ile Gly Pro Ser
    1810                1815                1820                
Cys Asp Asn Val Glu Glu Asp Met Asn Ala Ser Ala Gln Gly Ala Ser
1825                1830                1835                1840
Ala Thr Val Leu Glu Glu Thr Arg Lys Glu Thr Ala Pro Val Gln Leu
                1845                1850                1855    
Pro Val Ser Gly Pro Glu Leu Ala Ala Met Met Lys Ile Gly Thr Arg
            1860                1865                1870        
Val Met Arg Gly Val Asp Trp Lys Trp Gly Asp Gln Asp Gly Pro Pro
        1875                1880                1885            
Pro Gly Leu Gly Arg Val Ile Gly Glu Leu Gly Glu Asp Gly Trp Ile
    1890                1895                1900                
Arg Val Gln Trp Asp Thr Gly Ser Thr Asn Ser Tyr Arg Met Gly Lys
1905                1910                1915                1920
Glu Gly Lys Tyr Asp Leu Lys Leu Ala Glu Leu Pro Ala Ala Ala Gln
                1925                1930                1935    
Pro Ser Ala Glu Asp Ser Asp Thr Glu Asp Asp Ser Glu Ala Glu Gln
            1940                1945                1950        
Thr Glu Arg Asn Ile His Pro Thr Ala Met Met Phe Thr Ser Thr Ile
        1955                1960                1965            
Asn Leu Leu Gln Thr Leu Cys Leu Ser Ala Gly Val His Ala Glu Ile
    1970                1975                1980                
Met Gln Ser Glu Ala Thr Lys Thr Leu Cys Gly Leu Leu Arg Met Leu
1985                1990                1995                2000
Val Glu Ser Gly Thr Thr Asp Lys Thr Ser Ser Pro Asn Arg Leu Val
                2005                2010                2015    
Tyr Arg Glu Gln His Arg Ser Trp Cys Thr Leu Gly Phe Val Arg Ser
            2020                2025                2030        
Ile Ala Leu Thr Pro Gln Val Cys Gly Ala Leu Ser Ser Pro Gln Trp
        2035                2040                2045            
Ile Thr Leu Leu Met Lys Val Val Glu Gly His Ala Pro Phe Thr Ala
    2050                2055                2060                
Thr Ser Leu Gln Arg Gln Ile Leu Ala Val His Leu Leu Gln Ala Val
2065                2070                2075                2080
Leu Pro Ser Trp Asp Lys Thr Glu Arg Ala Arg Asp Met Lys Cys Leu
                2085                2090                2095    
Val Glu Lys Leu Phe Asp Phe Leu Gly Ser Leu Leu Thr Thr Cys Ser
            2100                2105                2110        
Ser Asp Val Pro Leu Leu Arg Glu Ser Thr Leu Arg Arg Arg Arg Val
        2115                2120                2125            
Arg Pro Gln Ala Ser Leu Thr Ala Thr His Ser Ser Thr Leu Ala Glu
    2130                2135                2140                
Glu Val Val Ala Leu Leu Arg Thr Leu His Ser Leu Thr Gln Trp Asn
2145                2150                2155                2160
Gly Leu Ile Asn Lys Tyr Ile Asn Ser Gln Leu Arg Ser Ile Thr His
                2165                2170                2175    
Ser Phe Val Gly Arg Pro Ser Glu Gly Ala Gln Leu Glu Asp Tyr Phe
            2180                2185                2190        
Pro Asp Ser Glu Asn Pro Glu Val Gly Gly Leu Met Ala Val Leu Ala
        2195                2200                2205            
Val Ile Gly Gly Ile Asp Gly Arg Leu Arg Leu Gly Gly Gln Val Met
    2210                2215                2220                
His Asp Glu Phe Gly Glu Gly Thr Val Thr Arg Ile Thr Pro Lys Gly
2225                2230                2235                2240
Lys Ile Thr Val Gln Phe Ser Asp Met Arg Thr Cys Arg Val Cys Pro
                2245                2250                2255    
Leu Asn Gln Leu Lys Pro Leu Pro Ala Val Ala Phe Asn Val Asn Asn
            2260                2265                2270        
Leu Pro Phe Thr Glu Pro Met Leu Ser Val Trp Ala Gln Leu Val Asn
        2275                2280                2285            
Leu Ala Gly Ser Lys Leu Glu Lys His Lys Ile Lys Lys Ser Thr Lys
    2290                2295                2300                
Gln Ala Phe Ala Gly Gln Val Asp Leu Asp Leu Leu Arg Cys Gln Gln
2305                2310                2315                2320
Leu Lys Leu Tyr Ile Leu Lys Ala Gly Arg Ala Leu Leu Ser His Gln
                2325                2330                2335    
Asp Lys Leu Arg Gln Ile Leu Ser Gln Pro Ala Val Gln Glu Thr Gly
            2340                2345                2350        
Thr Val His Thr Asp Asp Gly Ala Val Val Ser Pro Asp Leu Gly Asp
        2355                2360                2365            
Met Ser Pro Glu Gly Pro Gln Pro Pro Met Ile Leu Leu Gln Gln Leu
    2370                2375                2380                
Leu Ala Ser Ala Thr Gln Pro Ser Pro Val Lys Ala Ile Phe Asp Lys
2385                2390                2395                2400
Gln Glu Leu Glu Ala Ala Ala Leu Ala Val Cys Gln Cys Leu Ala Val
                2405                2410                2415    
Glu Ser Thr His Pro Ser Ser Pro Gly Phe Glu Asp Cys Ser Ser Ser
            2420                2425                2430        
Glu Ala Thr Thr Pro Val Ala Val Gln His Ile His Pro Ala Arg Val
        2435                2440                2445            
Lys Arg Arg Lys Gln Ser Pro Val Pro Ala Leu Pro Ile Val Val Gln
    2450                2455                2460                
Leu Met Glu Met Gly Phe Ser Arg Arg Asn Ile Glu Phe Ala Leu Lys
2465                2470                2475                2480
Ser Leu Thr Gly Ala Ser Gly Asn Ala Ser Ser Leu Pro Gly Val Glu
                2485                2490                2495    
Ala Leu Val Gly Trp Leu Leu Asp His Ser Asp Ile Gln Val Thr Glu
            2500                2505                2510        
Leu Ser Asp Ala Asp Thr Val Ser Asp Glu Tyr Ser Asp Glu Glu Val
        2515                2520                2525            
Val Glu Asp Val Asp Asp Ala Ala Tyr Ser Met Ser Thr Gly Ala Val
    2530                2535                2540                
Val Thr Glu Ser Gln Thr Tyr Lys Lys Arg Ala Asp Phe Leu Ser Asn
2545                2550                2555                2560
Asp Asp Tyr Ala Val Tyr Val Arg Glu Asn Ile Gln Val Gly Met Met
                2565                2570                2575    
Val Arg Cys Cys Arg Ala Tyr Glu Glu Val Cys Glu Gly Asp Val Gly
            2580                2585                2590        
Lys Val Ile Lys Leu Asp Arg Asp Gly Leu His Asp Leu Asn Val Gln
        2595                2600                2605            
Cys Asp Trp Gln Gln Lys Gly Gly Thr Tyr Trp Val Arg Tyr Ile His
    2610                2615                2620                
Val Glu Leu Ile Gly Tyr Pro Pro Pro Ser Ser Ser Ser His Ile Lys
2625                2630                2635                2640
Ile Gly Asp Lys Val Arg Val Lys Ala Ser Val Thr Thr Pro Lys Tyr
                2645                2650                2655    
Lys Trp Gly Ser Val Thr His Gln Ser Val Gly Val Val Lys Ala Phe
            2660                2665                2670        
Ser Ala Asn Gly Lys Asp Ile Ile Val Asp Phe Pro Gln Gln Ser His
        2675                2680                2685            
Trp Thr Gly Leu Leu Ser Glu Met Glu Leu Val Pro Ser Ile His Pro
    2690                2695                2700                
Gly Val Thr Cys Asp Gly Cys Gln Met Phe Pro Ile Asn Gly Ser Arg
2705                2710                2715                2720
Phe Lys Cys Arg Asn Cys Asp Asp Phe Asp Phe Cys Glu Thr Cys Phe
                2725                2730                2735    
Lys Thr Lys Lys His Asn Thr Arg His Thr Phe Gly Arg Ile Asn Glu
            2740                2745                2750        
Pro Gly Gln Ser Ala Val Phe Cys Gly Arg Ser Gly Lys Gln Leu Lys
        2755                2760                2765            
Arg Cys His Ser Ser Gln Pro Gly Met Leu Leu Asp Ser Trp Ser Arg
    2770                2775                2780                
Met Val Lys Ser Leu Asn Val Ser Ser Ser Val Asn Gln Ala Ser Arg
2785                2790                2795                2800
Leu Ile Asp Gly Ser Glu Pro Cys Trp Gln Ser Ser Gly Ser Gln Gly
                2805                2810                2815    
Lys His Trp Ile Arg Leu Glu Ile Phe Pro Asp Val Leu Val His Arg
            2820                2825                2830        
Leu Lys Met Ile Val Asp Pro Ala Asp Ser Ser Tyr Met Pro Ser Leu
        2835                2840                2845            
Val Val Val Ser Gly Gly Asn Ser Leu Asn Asn Leu Ile Glu Leu Lys
    2850                2855                2860                
Thr Ile Asn Ile Asn Pro Ser Asp Thr Thr Val Pro Leu Leu Asn Asp
2865                2870                2875                2880
Tyr Thr Glu Tyr His Arg Tyr Ile Glu Ile Ala Ile Lys Gln Cys Arg
                2885                2890                2895    
Ser Ser Gly Ile Asp Cys Lys Ile His Gly Leu Ile Leu Leu Gly Arg
            2900                2905                2910        
Ile Arg Ala Glu Glu Glu Asp Leu Ala Ala Val Pro Phe Leu Ala Ser
        2915                2920                2925            
Asp Asn Glu Glu Glu Glu Asp Glu Lys Gly Asn Ser Gly Ser Leu Ile
    2930                2935                2940                
Arg Lys Lys Ala Ala Gly Leu Glu Ser Ala Ala Thr Ile Arg Thr Lys
2945                2950                2955                2960
Val Phe Val Trp Gly Leu Asn Asp Lys Asp Gln Leu Gly Gly Leu Lys
                2965                2970                2975    
Gly Ser Lys Ile Lys Val Pro Ser Phe Ser Glu Thr Leu Ser Ala Leu
            2980                2985                2990        
Asn Val Val Gln Val Ala Gly Gly Ser Lys Ser Leu Phe Ala Val Thr
        2995                3000                3005            
Val Glu Gly Lys Val Tyr Ala Cys Gly Glu Ala Thr Asn Gly Arg Leu
    3010                3015                3020                
Gly Leu Gly Ile Ser Ser Gly Thr Val Pro Ile Pro Arg Gln Ile Thr
3025                3030                3035                3040
Ala Leu Ser Ser Tyr Val Val Lys Lys Val Ala Val His Ser Gly Gly
                3045                3050                3055    
Arg His Ala Thr Ala Leu Thr Val Asp Gly Lys Val Phe Ser Trp Gly
            3060                3065                3070        
Glu Gly Asp Asp Gly Lys Leu Gly His Phe Ser Arg Met Asn Cys Asp
        3075                3080                3085            
Lys Pro Arg Leu Ile Glu Ala Leu Lys Thr Lys Arg Ile Arg Asp Ile
    3090                3095                3100                
Ala Cys Gly Ser Ser His Ser Ala Ala Leu Thr Ser Ser Gly Glu Leu
3105                3110                3115                3120
Tyr Thr Trp Gly Leu Gly Glu Tyr Gly Arg Leu Gly His Gly Asp Asn
                3125                3130                3135    
Thr Thr Gln Leu Lys Pro Lys Met Val Lys Val Leu Leu Gly His Arg
            3140                3145                3150        
Val Ile Gln Val Ala Cys Gly Ser Arg Asp Ala Gln Thr Leu Ala Leu
        3155                3160                3165            
Thr Asp Glu Gly Leu Val Phe Ser Trp Gly Asp Gly Asp Phe Gly Lys
    3170                3175                3180                
Leu Gly Arg Gly Gly Ser Glu Gly Cys Asn Ile Pro Gln Asn Ile Glu
3185                3190                3195                3200
Arg Leu Asn Gly Gln Gly Val Cys Gln Ile Glu Cys Gly Ala Gln Phe
                3205                3210                3215    
Ser Leu Ala Leu Thr Lys Ser Gly Val Val Trp Thr Trp Gly Lys Gly
            3220                3225                3230        
Asp Tyr Phe Arg Leu Gly His Gly Ser Asp Val His Val Arg Lys Pro
        3235                3240                3245            
Gln Val Val Glu Gly Leu Arg Gly Lys Lys Ile Val His Val Ala Val
    3250                3255                3260                
Gly Ala Leu His Cys Leu Ala Val Thr Asp Ser Gly Gln Val Tyr Ala
3265                3270                3275                3280
Trp Gly Asp Asn Asp His Gly Gln Gln Gly Asn Gly Thr Thr Thr Val
                3285                3290                3295    
Asn Arg Lys Pro Thr Leu Val Gln Gly Leu Glu Gly Gln Lys Ile Thr
            3300                3305                3310        
Arg Val Ala Cys Gly Ser Ser His Ser Val Ala Trp Thr Thr Val Asp
        3315                3320                3325            
Val Ala Thr Pro Ser Val His Glu Pro Val Leu Phe Gln Thr Ala Arg
    3330                3335                3340                
Asp Pro Leu Gly Ala Ser Tyr Leu Gly Val Pro Ser Asp Ala Asp Ser
3345                3350                3355                3360
Ser Ala Ala Ser Asn Lys Ile Ser Gly Ala Ser Asn Ser Lys Pro Asn
                3365                3370                3375    
Arg Pro Ser Leu Ala Lys Ile Leu Leu Ser Leu Asp Gly Asn Leu Ala
            3380                3385                3390        
Lys Gln Gln Ala Leu Ser His Ile Leu Thr Ala Leu Gln Ile Met Tyr
        3395                3400                3405            
Ala Arg Asp Ala Val Val Gly Ala Leu Met Pro Ala Ala Met Ile Ala
    3410                3415                3420                
Pro Val Glu Cys Pro Ser Phe Ser Ser Ala Ala Pro Ser Asp Ala Ser
3425                3430                3435                3440
Ala Met Ala Ser Pro Met Asn Gly Glu Glu Cys Met Leu Ala Val Asp
                3445                3450                3455    
Ile Glu Asp Arg Leu Ser Pro Asn Pro Trp Gln Glu Lys Arg Glu Ile
            3460                3465                3470        
Val Ser Ser Glu Asp Ala Val Thr Pro Ser Ala Val Thr Pro Ser Ala
        3475                3480                3485            
Pro Ser Ala Ser Ala Arg Pro Phe Ile Pro Val Thr Asp Asp Leu Gly
    3490                3495                3500                
Ala Ala Ser Ile Ile Ala Glu Thr Met Thr Lys Thr Lys Glu Asp Val
3505                3510                3515                3520
Glu Ser Gln Asn Lys Ala Ala Gly Pro Glu Pro Gln Ala Leu Asp Glu
                3525                3530                3535    
Phe Thr Ser Leu Leu Ile Ala Asp Asp Thr Arg Val Val Val Asp Leu
            3540                3545                3550        
Leu Lys Leu Ser Val Cys Ser Arg Ala Gly Asp Arg Gly Arg Asp Val
        3555                3560                3565            
Leu Ser Ala Val Leu Ser Gly Met Gly Thr Ala Tyr Pro Gln Val Ala
    3570                3575                3580                
Asp Met Leu Leu Glu Leu Cys Val Thr Glu Leu Glu Asp Val Ala Thr
3585                3590                3595                3600
Asp Ser Gln Ser Gly Arg Leu Ser Ser Gln Pro Val Val Val Glu Ser
                3605                3610                3615    
Ser His Pro Tyr Thr Asp Asp Thr Ser Thr Ser Gly Thr Val Lys Ile
            3620                3625                3630        
Pro Gly Ala Glu Gly Leu Arg Val Glu Phe Asp Arg Gln Cys Ser Thr
        3635                3640                3645            
Glu Arg Arg His Asp Pro Leu Thr Val Met Asp Gly Val Asn Arg Ile
    3650                3655                3660                
Val Ser Val Arg Ser Gly Arg Glu Trp Ser Asp Trp Ser Ser Glu Leu
3665                3670                3675                3680
Arg Ile Pro Gly Asp Glu Leu Lys Trp Lys Phe Ile Ser Asp Gly Ser
                3685                3690                3695    
Val Asn Gly Trp Gly Trp Arg Phe Thr Val Tyr Pro Ile Met Pro Ala
            3700                3705                3710        
Ala Gly Pro Lys Glu Leu Leu Ser Asp Arg Cys Val Leu Ser Cys Pro
        3715                3720                3725            
Ser Met Asp Leu Val Thr Cys Leu Leu Asp Phe Arg Leu Asn Leu Ala
    3730                3735                3740                
Ser Asn Arg Ser Ile Val Pro Arg Leu Ala Ala Ser Leu Ala Ala Cys
3745                3750                3755                3760
Ala Gln Leu Ser Ala Leu Ala Ala Ser His Arg Met Trp Ala Leu Gln
                3765                3770                3775    
Arg Leu Arg Lys Leu Leu Thr Thr Glu Phe Gly Gln Ser Ile Asn Ile
            3780                3785                3790        
Asn Arg Leu Leu Gly Glu Asn Asp Gly Glu Thr Arg Ala Leu Ser Phe
        3795                3800                3805            
Thr Gly Ser Ala Leu Ala Ala Leu Val Lys Gly Leu Pro Glu Ala Leu
    3810                3815                3820                
Gln Arg Gln Phe Glu Tyr Glu Asp Pro Ile Val Arg Gly Gly Lys Gln
3825                3830                3835                3840
Leu Leu His Ser Pro Phe Phe Lys Val Leu Val Ala Leu Ala Cys Asp
                3845                3850                3855    
Leu Glu Leu Asp Thr Leu Pro Cys Cys Ala Glu Thr His Lys Trp Ala
            3860                3865                3870        
Trp Phe Arg Arg Tyr Cys Met Ala Ser Arg Val Ala Val Ala Leu Asp
        3875                3880                3885            
Lys Arg Thr Pro Leu Pro Arg Leu Phe Leu Asp Glu Val Ala Lys Lys
    3890                3895                3900                
Ile Arg Glu Leu Met Ala Asp Ser Glu Asn Met Asp Val Leu His Glu
3905                3910                3915                3920
Ser His Asp Ile Phe Lys Arg Glu Gln Asp Glu Gln Leu Val Gln Trp
                3925                3930                3935    
Met Asn Arg Arg Pro Asp Asp Trp Thr Leu Ser Ala Gly Gly Ser Gly
            3940                3945                3950        
Thr Ile Tyr Gly Trp Gly His Asn His Arg Gly Gln Leu Gly Gly Ile
        3955                3960                3965            
Glu Gly Ala Lys Val Lys Val Pro Thr Pro Cys Glu Ala Leu Ala Thr
    3970                3975                3980                
Leu Arg Pro Val Gln Leu Ile Gly Gly Glu Gln Thr Leu Phe Ala Val
3985                3990                3995                4000
Thr Ala Asp Gly Lys Leu Tyr Ala Thr Gly Tyr Gly Ala Gly Gly Arg
                4005                4010                4015    
Leu Gly Ile Gly Gly Thr Glu Ser Val Ser Thr Pro Thr Leu Leu Glu
            4020                4025                4030        
Ser Ile Gln His Val Phe Ile Lys Lys Val Ala Val Asn Ser Gly Gly
        4035                4040                4045            
Lys His Cys Leu Ala Leu Ser Ser Glu Gly Glu Val Tyr Ser Trp Gly
    4050                4055                4060                
Glu Ala Glu Asp Gly Lys Leu Gly His Gly Asn Arg Ser Pro Cys Asp
4065                4070                4075                4080
Arg Pro Arg Val Ile Glu Ser Leu Arg Gly Ile Glu Val Val Asp Val
                4085                4090                4095    
Ala Ala Gly Gly Ala His Ser Ala Cys Val Thr Ala Ala Gly Asp Leu
            4100                4105                4110        
Tyr Thr Trp Gly Lys Gly Arg Tyr Gly Arg Leu Gly His Ser Asp Ser
        4115                4120                4125            
Glu Asp Gln Leu Lys Pro Lys Leu Val Glu Ala Leu Gln Gly His Arg
    4130                4135                4140                
Val Val Asp Ile Ala Cys Gly Ser Gly Asp Ala Gln Thr Leu Cys Leu
4145                4150                4155                4160
Thr Asp Asp Asp Thr Val Trp Ser Trp Gly Asp Gly Asp Tyr Gly Lys
                4165                4170                4175    
Leu Gly Arg Gly Gly Ser Asp Gly Cys Lys Val Pro Met Lys Ile Asp
            4180                4185                4190        
Ser Leu Thr Gly Leu Gly Val Val Lys Val Glu Cys Gly Ser Gln Phe
        4195                4200                4205            
Ser Val Ala Leu Thr Lys Ser Gly Ala Val Tyr Thr Trp Gly Lys Gly
    4210                4215                4220                
Asp Tyr His Arg Leu Gly His Gly Ser Asp Asp His Val Arg Arg Pro
4225                4230                4235                4240
Arg Gln Val Gln Gly Leu Gln Gly Lys Lys Val Ile Ala Ile Ala Thr
                4245                4250                4255    
Gly Ser Leu His Cys Val Cys Cys Thr Glu Asp Gly Glu Val Tyr Thr
            4260                4265                4270        
Trp Gly Asp Asn Asp Glu Gly Gln Leu Gly Asp Gly Thr Thr Asn Ala
        4275                4280                4285            
Ile Gln Arg Pro Arg Leu Val Ala Ala Leu Gln Gly Lys Lys Val Asn
    4290                4295                4300                
Arg Val Ala Cys Gly Ser Ala His Thr Leu Ala Trp Ser Thr Ser Lys
4305                4310                4315                4320
Pro Ala Ser Ala Gly Lys Leu Pro Ala Gln Val Pro Met Glu Tyr Asn
                4325                4330                4335    
His Leu Gln Glu Ile Pro Ile Ile Ala Leu Arg Asn Arg Leu Leu Leu
            4340                4345                4350        
Leu His His Leu Ser Glu Leu Phe Cys Pro Cys Ile Pro Met Phe Asp
        4355                4360                4365            
Leu Glu Gly Ser Leu Asp Glu Thr Gly Leu Gly Pro Ser Val Gly Phe
    4370                4375                4380                
Asp Thr Leu Arg Gly Ile Leu Ile Ser Gln Gly Lys Glu Ala Ala Phe
4385                4390                4395                4400
Arg Lys Val Val Gln Ala Thr Met Val Arg Asp Arg Gln His Gly Pro
                4405                4410                4415    
Val Val Glu Leu Asn Arg Ile Gln Val Lys Arg Ser Arg Ser Lys Gly
            4420                4425                4430        
Gly Leu Ala Gly Pro Asp Gly Thr Lys Ser Val Phe Gly Gln Met Cys
        4435                4440                4445            
Ala Lys Met Ser Ser Phe Gly Pro Asp Ser Leu Leu Leu Pro His Arg
    4450                4455                4460                
Val Trp Lys Val Lys Phe Val Gly Glu Ser Val Asp Asp Cys Gly Gly
4465                4470                4475                4480
Gly Tyr Ser Glu Ser Ile Ala Glu Ile Cys Glu Glu Leu Gln Asn Gly
                4485                4490                4495    
Leu Thr Pro Leu Leu Ile Val Thr Pro Asn Gly Arg Asp Glu Ser Gly
            4500                4505                4510        
Ala Asn Arg Asp Cys Tyr Leu Leu Ser Pro Ala Ala Arg Ala Pro Val
        4515                4520                4525            
His Ser Ser Met Phe Arg Phe Leu Gly Val Leu Leu Gly Ile Ala Ile
    4530                4535                4540                
Arg Thr Gly Ser Pro Leu Ser Leu Asn Leu Ala Glu Pro Val Trp Lys
4545                4550                4555                4560
Gln Leu Ala Gly Met Ser Leu Thr Ile Ala Asp Leu Ser Glu Val Asp
                4565                4570                4575    
Lys Asp Phe Ile Pro Gly Leu Met Tyr Ile Arg Asp Asn Glu Ala Thr
            4580                4585                4590        
Ser Glu Glu Phe Glu Ala Met Ser Leu Pro Phe Thr Val Pro Ser Ala
        4595                4600                4605            
Ser Gly Gln Asp Ile Gln Leu Ser Ser Lys His Thr His Ile Thr Leu
    4610                4615                4620                
Asp Asn Arg Ala Glu Tyr Val Arg Leu Ala Ile Asn Tyr Arg Leu His
4625                4630                4635                4640
Glu Phe Asp Glu Gln Val Ala Ala Val Arg Glu Gly Met Ala Arg Val
                4645                4650                4655    
Val Pro Val Pro Leu Leu Ser Leu Phe Thr Gly Tyr Glu Leu Glu Thr
            4660                4665                4670        
Met Val Cys Gly Ser Pro Asp Ile Pro Leu His Leu Leu Lys Ser Val
        4675                4680                4685            
Ala Thr Tyr Lys Gly Ile Glu Pro Ser Ala Ser Leu Ile Gln Trp Phe
    4690                4695                4700                
Trp Glu Val Met Glu Ser Phe Ser Asn Thr Glu Arg Ser Leu Phe Leu
4705                4710                4715                4720
Arg Phe Val Trp Gly Arg Thr Arg Leu Pro Arg Thr Ile Ala Asp Phe
                4725                4730                4735    
Arg Gly Arg Asp Phe Val Ile Gln Val Leu Asp Lys Tyr Asn Pro Pro
            4740                4745                4750        
Asp His Phe Leu Pro Glu Ser Tyr Thr Cys Phe Phe Leu Leu Lys Leu
        4755                4760                4765            
Pro Arg Tyr Ser Cys Lys Gln Val Leu Glu Glu Lys Leu Lys Tyr Ala
    4770                4775                4780                
Ile His Phe Cys Lys Ser Ile Asp Thr Asp Asp Tyr Ala Arg Ile Ala
4785                4790                4795                4800
Leu Thr Gly Glu Pro Ala Ala Asp Asp Ser Ser Asp Asp Ser Asp Asn
                4805                4810                4815    
Glu Asp Val Asp Ser Phe Ala Ser Asp Ser Thr Gln Asp Tyr Leu Thr
            4820                4825                4830        
Gly His
        


<210> 591
<211> 4834
<212> PRT
<213> Homo sapiens

<400> 591
Met Pro Ser Glu Ser Phe Cys Leu Ala Ala Gln Ala Arg Leu Asp Ser
 1               5                  10                  15      
Lys Trp Leu Lys Thr Asp Ile Gln Leu Ala Phe Thr Arg Asp Gly Leu
            20                  25                  30          
Cys Gly Leu Trp Asn Glu Met Val Lys Asp Gly Glu Ile Val Tyr Thr
        35                  40                  45              
Gly Thr Glu Ser Thr Gln Asn Gly Glu Leu Pro Pro Arg Lys Asp Asp
    50                  55                  60                  
Ser Val Glu Pro Ser Gly Thr Lys Lys Glu Asp Leu Asn Asp Lys Glu
65                  70                  75                  80  
Lys Lys Asp Glu Glu Glu Thr Pro Ala Pro Ile Tyr Arg Ala Lys Ser
                85                  90                  95      
Ile Leu Asp Ser Trp Val Trp Gly Lys Gln Pro Asp Val Asn Glu Leu
            100                 105                 110         
Lys Glu Cys Leu Ser Val Leu Val Lys Glu Gln Gln Ala Leu Ala Val
        115                 120                 125             
Gln Ser Ala Thr Thr Thr Leu Ser Ala Leu Arg Leu Lys Gln Arg Leu
    130                 135                 140                 
Val Ile Leu Glu Arg Tyr Phe Ile Ala Leu Asn Arg Thr Val Phe Gln
145                 150                 155                 160 
Glu Asn Val Lys Val Lys Trp Lys Ser Ser Gly Ile Ser Leu Pro Pro
                165                 170                 175     
Val Asp Lys Lys Ser Ser Arg Pro Ala Gly Lys Gly Val Glu Gly Leu
            180                 185                 190         
Ala Arg Val Gly Ser Arg Ala Ala Leu Ser Phe Ala Phe Ala Phe Leu
        195                 200                 205             
Arg Arg Ala Trp Arg Ser Gly Glu Asp Ala Asp Leu Cys Ser Glu Leu
    210                 215                 220                 
Leu Gln Glu Ser Leu Asp Ala Leu Arg Ala Leu Pro Glu Ala Ser Leu
225                 230                 235                 240 
Phe Asp Glu Ser Thr Val Ser Ser Val Trp Leu Glu Val Val Glu Arg
                245                 250                 255     
Ala Thr Arg Phe Leu Arg Ser Val Val Thr Gly Asp Val His Gly Thr
            260                 265                 270         
Pro Ala Thr Lys Gly Pro Gly Ser Ile Pro Leu Gln Asp Gln His Leu
        275                 280                 285             
Ala Leu Ala Ile Leu Leu Glu Leu Ala Val Gln Arg Gly Thr Leu Ser
    290                 295                 300                 
Gln Met Leu Ser Ala Ile Leu Leu Leu Leu Gln Leu Trp Asp Ser Gly
305                 310                 315                 320 
Ala Gln Glu Thr Asp Asn Glu Arg Ser Ala Gln Gly Thr Ser Ala Pro
                325                 330                 335     
Leu Leu Pro Leu Leu Gln Arg Phe Gln Ser Ile Ile Cys Arg Lys Asp
            340                 345                 350         
Ala Pro His Ser Glu Gly Asp Met His Leu Leu Ser Gly Pro Leu Ser
        355                 360                 365             
Pro Asn Glu Ser Phe Leu Arg Tyr Leu Thr Leu Pro Gln Asp Asn Glu
    370                 375                 380                 
Leu Ala Ile Asp Leu Arg Gln Thr Ala Val Val Val Met Ala His Leu
385                 390                 395                 400 
Asp Arg Leu Ala Thr Pro Cys Met Pro Pro Leu Cys Ser Ser Pro Thr
                405                 410                 415     
Ser His Lys Gly Ser Leu Gln Glu Val Ile Gly Trp Gly Leu Ile Gly
            420                 425                 430         
Trp Lys Tyr Tyr Ala Asn Val Ile Gly Pro Ile Gln Cys Glu Gly Leu
        435                 440                 445             
Ala Asn Leu Gly Val Thr Gln Ile Ala Cys Ala Glu Lys Arg Phe Leu
    450                 455                 460                 
Ile Leu Ser Arg Asn Gly Arg Val Tyr Thr Gln Ala Tyr Asn Ser Asp
465                 470                 475                 480 
Thr Leu Ala Pro Gln Leu Val Gln Gly Leu Ala Ser Arg Asn Ile Val
                485                 490                 495     
Lys Ile Ala Ala His Ser Asp Gly His His Tyr Leu Ala Leu Ala Ala
            500                 505                 510         
Thr Gly Glu Val Tyr Ser Trp Gly Cys Gly Asp Gly Gly Arg Leu Gly
        515                 520                 525             
His Gly Asp Thr Val Pro Leu Glu Glu Pro Lys Val Ile Ser Ala Phe
    530                 535                 540                 
Ser Gly Lys Gln Ala Gly Lys His Val Val His Ile Ala Cys Gly Ser
545                 550                 555                 560 
Thr Tyr Ser Ala Ala Ile Thr Ala Glu Gly Glu Leu Tyr Thr Trp Gly
                565                 570                 575     
Arg Gly Asn Tyr Gly Arg Leu Gly His Gly Ser Ser Glu Asp Glu Ala
            580                 585                 590         
Ile Pro Met Leu Val Ala Gly Leu Lys Gly Leu Lys Val Ile Asp Val
        595                 600                 605             
Ala Cys Gly Ser Gly Asp Ala Gln Thr Leu Ala Val Thr Glu Asn Gly
    610                 615                 620                 
Gln Val Trp Ser Trp Gly Asp Gly Asp Tyr Gly Lys Leu Gly Arg Gly
625                 630                 635                 640 
Gly Ser Asp Gly Cys Lys Thr Pro Lys Leu Ile Glu Lys Leu Gln Asp
                645                 650                 655     
Leu Asp Val Val Lys Val Arg Cys Gly Ser Gln Phe Ser Ile Ala Leu
            660                 665                 670         
Thr Lys Asp Gly Gln Val Tyr Ser Trp Gly Lys Gly Asp Asn Gln Arg
        675                 680                 685             
Leu Gly His Gly Thr Glu Glu His Val Arg Tyr Pro Lys Leu Leu Glu
    690                 695                 700                 
Gly Leu Gln Gly Lys Lys Val Ile Asp Val Ala Ala Gly Ser Thr His
705                 710                 715                 720 
Cys Leu Ala Leu Thr Glu Asp Ser Glu Val His Ser Trp Gly Ser Asn
                725                 730                 735     
Asp Gln Cys Gln His Phe Asp Thr Leu Arg Val Thr Lys Pro Glu Pro
            740                 745                 750         
Ala Ala Leu Pro Gly Leu Asp Thr Lys His Ile Val Gly Ile Ala Cys
        755                 760                 765             
Gly Pro Ala Gln Ser Phe Ala Trp Ser Ser Cys Ser Glu Trp Ser Ile
    770                 775                 780                 
Gly Leu Arg Val Pro Phe Val Val Asp Ile Cys Ser Met Thr Phe Glu
785                 790                 795                 800 
Gln Leu Asp Leu Leu Leu Arg Gln Val Ser Glu Gly Met Asp Gly Ser
                805                 810                 815     
Ala Asp Trp Pro Pro Pro Gln Glu Lys Glu Cys Val Ala Val Ala Thr
            820                 825                 830         
Leu Asn Leu Leu Arg Leu Gln Leu His Ala Ala Ile Ser His Gln Val
        835                 840                 845             
Asp Pro Glu Phe Leu Gly Leu Gly Leu Gly Ser Ile Leu Leu Asn Ser
    850                 855                 860                 
Leu Lys Gln Thr Val Val Thr Leu Ala Ser Ser Ala Gly Val Leu Ser
865                 870                 875                 880 
Thr Val Gln Ser Ala Ala Gln Ala Val Leu Gln Ser Gly Trp Ser Val
                885                 890                 895     
Leu Leu Pro Thr Ala Glu Glu Arg Ala Arg Ala Leu Ser Ala Leu Leu
            900                 905                 910         
Pro Cys Ala Val Ser Gly Asn Glu Val Asn Ile Ser Pro Gly Arg Arg
        915                 920                 925             
Phe Met Ile Asp Leu Leu Val Gly Ser Leu Met Ala Asp Gly Gly Leu
    930                 935                 940                 
Glu Ser Ala Leu His Ala Ala Ile Thr Ala Glu Ile Gln Asp Ile Glu
945                 950                 955                 960 
Ala Lys Lys Glu Ala Gln Lys Glu Lys Glu Ile Asp Glu Gln Glu Ala
                965                 970                 975     
Asn Ala Ser Thr Phe His Arg Ser Arg Thr Pro Leu Asp Lys Asp Leu
            980                 985                 990         
Ile Asn Thr Gly Ile Cys Glu Ser Ser Gly Lys Gln Cys Leu Pro Leu
        995                 1000                1005            
Val Gln Leu Ile Gln Gln Leu Leu Arg Asn Ile Ala Ser Gln Thr Val
    1010                1015                1020                
Ala Arg Leu Lys Asp Val Ala Arg Arg Ile Ser Ser Cys Leu Asp Phe
1025                1030                1035                1040
Glu Gln His Ser Arg Glu Arg Ser Ala Ser Leu Asp Trp Leu Leu Arg
                1045                1050                1055    
Phe Gln Arg Leu Leu Ile Ser Lys Leu Tyr Pro Gly Glu Ser Ile Gly
            1060                1065                1070        
Gln Thr Ser Asp Ile Ser Ser Pro Glu Leu Met Gly Val Gly Ser Leu
        1075                1080                1085            
Leu Lys Lys Tyr Thr Ala Leu Leu Cys Thr His Ile Gly Asp Ile Leu
    1090                1095                1100                
Pro Val Ala Ala Ser Ile Ala Ser Thr Ser Trp Arg His Phe Ala Glu
1105                1110                1115                1120
Val Ala Tyr Ile Val Glu Gly Asp Phe Thr Gly Val Leu Leu Pro Glu
                1125                1130                1135    
Leu Val Val Ser Ile Val Leu Leu Leu Ser Lys Asn Ala Asp Leu Met
            1140                1145                1150        
Gln Glu Ala Gly Ala Val Pro Leu Leu Gly Gly Leu Leu Glu His Leu
        1155                1160                1165            
Asp Arg Phe Asn His Leu Ala Pro Gly Lys Glu Arg Asp Asp His Glu
    1170                1175                1180                
Glu Leu Ala Trp Pro Gly Ile Met Glu Ser Phe Phe Thr Gly Gln Asn
1185                1190                1195                1200
Cys Arg Asn Asn Glu Glu Val Thr Leu Ile Arg Lys Ala Asp Leu Glu
                1205                1210                1215    
Asn His Asn Lys Asp Gly Gly Phe Trp Thr Val Ile Asp Gly Lys Val
            1220                1225                1230        
Tyr Asp Ile Lys Asp Phe Gln Thr Gln Ser Leu Thr Gly Asn Ser Ile
        1235                1240                1245            
Leu Ala Gln Phe Ala Gly Glu Asp Pro Val Val Ala Leu Glu Ala Ala
    1250                1255                1260                
Leu Gln Phe Glu Asp Thr Arg Glu Ser Met His Ala Phe Cys Val Gly
1265                1270                1275                1280
Gln Tyr Leu Glu Pro Asp Gln Glu Ile Val Thr Ile Pro Asp Leu Gly
                1285                1290                1295    
Ser Leu Ser Ser Pro Leu Ile Asp Thr Glu Arg Asn Leu Gly Leu Leu
            1300                1305                1310        
Leu Gly Leu His Ala Ser Tyr Leu Ala Met Ser Thr Pro Leu Ser Pro
        1315                1320                1325            
Val Glu Ile Glu Cys Ala Lys Trp Leu Gln Ser Ser Ile Phe Ser Gly
    1330                1335                1340                
Gly Leu Gln Thr Ser Gln Ile His Tyr Arg Tyr Asn Glu Glu Lys Asp
1345                1350                1355                1360
Glu Asp His Cys Ser Ser Pro Gly Gly Thr Pro Ala Ser Lys Ser Arg
                1365                1370                1375    
Leu Cys Ser His Arg Arg Ala Leu Gly Asp His Ser Gln Ala Phe Leu
            1380                1385                1390        
Gln Ala Ile Ala Asp Asn Asn Ile Gln Asp His Asn Val Lys Asp Phe
        1395                1400                1405            
Leu Cys Gln Ile Glu Arg Tyr Cys Arg Gln Cys His Leu Thr Thr Pro
    1410                1415                1420                
Ile Met Phe Pro Pro Glu His Pro Val Glu Glu Val Gly Arg Leu Leu
1425                1430                1435                1440
Leu Cys Cys Leu Leu Lys His Glu Asp Leu Gly His Val Ala Leu Ser
                1445                1450                1455    
Leu Val His Ala Gly Ala Leu Gly Ile Glu Gln Val Lys His Arg Thr
            1460                1465                1470        
Leu Pro Lys Ser Val Val Asp Val Cys Arg Val Val Tyr Gln Ala Lys
        1475                1480                1485            
Cys Ser Leu Ile Lys Thr His Gln Glu Gln Gly Arg Ser Tyr Lys Glu
    1490                1495                1500                
Val Cys Ala Pro Val Ile Glu Arg Leu Arg Phe Leu Phe Asn Glu Leu
1505                1510                1515                1520
Arg Pro Ala Val Cys Asn Asp Leu Ser Ile Met Ser Lys Phe Lys Leu
                1525                1530                1535    
Leu Ser Ser Leu Pro Arg Trp Arg Arg Ile Ala Gln Lys Ile Ile Arg
            1540                1545                1550        
Glu Arg Arg Lys Lys Arg Val Pro Lys Lys Pro Glu Ser Met Asp Asp
        1555                1560                1565            
Glu Glu Lys Ile Gly Asn Glu Glu Ser Asp Leu Glu Glu Ala Cys Ile
    1570                1575                1580                
Leu Pro His Ser Pro Ile Asn Val Asp Lys Arg Pro Ile Ala Ile Lys
1585                1590                1595                1600
Ser Pro Lys Asp Lys Trp Gln Pro Leu Leu Ser Thr Val Thr Gly Val
                1605                1610                1615    
His Lys Tyr Lys Trp Leu Lys Gln Asn Val Gln Gly Leu Tyr Pro Gln
            1620                1625                1630        
Ser Pro Leu Leu Ser Thr Ile Ala Glu Phe Ala Leu Lys Glu Glu Pro
        1635                1640                1645            
Val Asp Val Glu Lys Met Arg Lys Cys Leu Leu Lys Gln Leu Glu Arg
    1650                1655                1660                
Ala Glu Val Arg Leu Glu Gly Ile Asp Thr Ile Leu Lys Leu Ala Ser
1665                1670                1675                1680
Lys Asn Phe Leu Leu Pro Ser Val Gln Tyr Ala Met Phe Cys Gly Trp
                1685                1690                1695    
Gln Arg Leu Ile Pro Glu Gly Ile Asp Ile Gly Glu Pro Leu Thr Asp
            1700                1705                1710        
Cys Leu Lys Asp Val Asp Leu Ile Pro Pro Phe Asn Arg Met Leu Leu
        1715                1720                1725            
Glu Val Thr Phe Gly Lys Leu Tyr Ala Trp Ala Val Gln Asn Ile Arg
    1730                1735                1740                
Asn Val Leu Met Asp Ala Ser Ala Thr Phe Lys Glu Leu Gly Ile Gln
1745                1750                1755                1760
Pro Val Pro Leu Gln Thr Ile Thr Asn Glu Asn Pro Ser Gly Pro Ser
                1765                1770                1775    
Leu Gly Thr Ile Pro Gln Ala Arg Phe Leu Leu Val Met Leu Ser Met
            1780                1785                1790        
Leu Thr Leu Gln His Gly Ala Asn Asn Leu Asp Leu Leu Leu Asn Ser
        1795                1800                1805            
Gly Met Leu Ala Leu Thr Gln Thr Ala Leu Arg Leu Ile Gly Pro Ser
    1810                1815                1820                
Cys Asp Asn Val Glu Glu Asp Met Asn Ala Ser Ala Gln Gly Ala Ser
1825                1830                1835                1840
Ala Thr Val Leu Glu Glu Thr Arg Lys Glu Thr Ala Pro Val Gln Leu
                1845                1850                1855    
Pro Val Ser Gly Pro Glu Leu Ala Ala Met Met Lys Ile Gly Thr Arg
            1860                1865                1870        
Val Met Arg Gly Val Asp Trp Lys Trp Gly Asp Gln Asp Gly Pro Pro
        1875                1880                1885            
Pro Gly Leu Gly Arg Val Ile Gly Glu Leu Gly Glu Asp Gly Trp Ile
    1890                1895                1900                
Arg Val Gln Trp Asp Thr Gly Ser Thr Asn Ser Tyr Arg Met Gly Lys
1905                1910                1915                1920
Glu Gly Lys Tyr Asp Leu Lys Leu Ala Glu Leu Pro Ala Ala Ala Gln
                1925                1930                1935    
Pro Ser Ala Glu Asp Ser Asp Thr Glu Asp Asp Ser Glu Ala Glu Gln
            1940                1945                1950        
Thr Glu Arg Asn Ile His Pro Thr Ala Met Met Phe Thr Ser Thr Ile
        1955                1960                1965            
Asn Leu Leu Gln Thr Leu Cys Leu Ser Ala Gly Val His Ala Glu Ile
    1970                1975                1980                
Met Gln Ser Glu Ala Thr Lys Thr Leu Cys Gly Leu Leu Arg Met Leu
1985                1990                1995                2000
Val Glu Ser Gly Thr Thr Asp Lys Thr Ser Ser Pro Asn Arg Leu Val
                2005                2010                2015    
Tyr Arg Glu Gln His Arg Ser Trp Cys Thr Leu Gly Phe Val Arg Ser
            2020                2025                2030        
Ile Ala Leu Thr Pro Gln Val Cys Gly Ala Leu Ser Ser Pro Gln Trp
        2035                2040                2045            
Ile Thr Leu Leu Met Lys Val Val Glu Gly His Ala Pro Phe Thr Ala
    2050                2055                2060                
Thr Ser Leu Gln Arg Gln Ile Leu Ala Val His Leu Leu Gln Ala Val
2065                2070                2075                2080
Leu Pro Ser Trp Asp Lys Thr Glu Arg Ala Arg Asp Met Lys Cys Leu
                2085                2090                2095    
Val Glu Lys Leu Phe Asp Phe Leu Gly Ser Leu Leu Thr Thr Cys Ser
            2100                2105                2110        
Ser Asp Val Pro Leu Leu Arg Glu Ser Thr Leu Arg Arg Arg Arg Val
        2115                2120                2125            
Arg Pro Gln Ala Ser Leu Thr Ala Thr His Ser Ser Thr Leu Ala Glu
    2130                2135                2140                
Glu Val Val Ala Leu Leu Arg Thr Leu His Ser Leu Thr Gln Trp Asn
2145                2150                2155                2160
Gly Leu Ile Asn Lys Tyr Ile Asn Ser Gln Leu Arg Ser Ile Thr His
                2165                2170                2175    
Ser Phe Val Gly Arg Pro Ser Glu Gly Ala Gln Leu Glu Asp Tyr Phe
            2180                2185                2190        
Pro Asp Ser Glu Asn Pro Glu Val Gly Gly Leu Met Ala Val Leu Ala
        2195                2200                2205            
Val Ile Gly Gly Ile Asp Gly Arg Leu Arg Leu Gly Gly Gln Val Met
    2210                2215                2220                
His Asp Glu Phe Gly Glu Gly Thr Val Thr Arg Ile Thr Pro Lys Gly
2225                2230                2235                2240
Lys Ile Thr Val Gln Phe Ser Asp Met Arg Thr Cys Arg Val Cys Pro
                2245                2250                2255    
Leu Asn Gln Leu Lys Pro Leu Pro Ala Val Ala Phe Asn Val Asn Asn
            2260                2265                2270        
Leu Pro Phe Thr Glu Pro Met Leu Ser Val Trp Ala Gln Leu Val Asn
        2275                2280                2285            
Leu Ala Gly Ser Lys Leu Glu Lys His Lys Ile Lys Lys Ser Thr Lys
    2290                2295                2300                
Gln Ala Phe Ala Gly Gln Val Asp Leu Asp Leu Leu Arg Cys Gln Gln
2305                2310                2315                2320
Leu Lys Leu Tyr Ile Leu Lys Ala Gly Arg Ala Leu Leu Ser His Gln
                2325                2330                2335    
Asp Lys Leu Arg Gln Ile Leu Ser Gln Pro Ala Val Gln Glu Thr Gly
            2340                2345                2350        
Thr Val His Thr Asp Asp Gly Ala Val Val Ser Pro Asp Leu Gly Asp
        2355                2360                2365            
Met Ser Pro Glu Gly Pro Gln Pro Pro Met Ile Leu Leu Gln Gln Leu
    2370                2375                2380                
Leu Ala Ser Ala Thr Gln Pro Ser Pro Val Lys Ala Ile Phe Asp Lys
2385                2390                2395                2400
Gln Glu Leu Glu Ala Ala Ala Leu Ala Val Cys Gln Cys Leu Ala Val
                2405                2410                2415    
Glu Ser Thr His Pro Ser Ser Pro Gly Phe Glu Asp Cys Ser Ser Ser
            2420                2425                2430        
Glu Ala Thr Thr Pro Val Ala Val Gln His Ile His Pro Ala Arg Val
        2435                2440                2445            
Lys Arg Arg Lys Gln Ser Pro Val Pro Ala Leu Pro Ile Val Val Gln
    2450                2455                2460                
Leu Met Glu Met Gly Phe Ser Arg Arg Asn Ile Glu Phe Ala Leu Lys
2465                2470                2475                2480
Ser Leu Thr Gly Ala Ser Gly Asn Ala Ser Ser Leu Pro Gly Val Glu
                2485                2490                2495    
Ala Leu Val Gly Trp Leu Leu Asp His Ser Asp Ile Gln Val Thr Glu
            2500                2505                2510        
Leu Ser Asp Ala Asp Thr Val Ser Asp Glu Tyr Ser Asp Glu Glu Val
        2515                2520                2525            
Val Glu Asp Val Asp Asp Ala Ala Tyr Ser Met Ser Thr Gly Ala Val
    2530                2535                2540                
Val Thr Glu Ser Gln Thr Tyr Lys Lys Arg Ala Asp Phe Leu Ser Asn
2545                2550                2555                2560
Asp Asp Tyr Ala Val Tyr Val Arg Glu Asn Ile Gln Val Gly Met Met
                2565                2570                2575    
Val Arg Cys Cys Arg Ala Tyr Glu Glu Val Cys Glu Gly Asp Val Gly
            2580                2585                2590        
Lys Val Ile Lys Leu Asp Arg Asp Gly Leu His Asp Leu Asn Val Gln
        2595                2600                2605            
Cys Asp Trp Gln Gln Lys Gly Gly Thr Tyr Trp Val Arg Tyr Ile His
    2610                2615                2620                
Val Glu Leu Ile Gly Tyr Pro Pro Pro Ser Ser Ser Ser His Ile Lys
2625                2630                2635                2640
Ile Gly Asp Lys Val Arg Val Lys Ala Ser Val Thr Thr Pro Lys Tyr
                2645                2650                2655    
Lys Trp Gly Ser Val Thr His Gln Ser Val Gly Val Val Lys Ala Phe
            2660                2665                2670        
Ser Ala Asn Gly Lys Asp Ile Ile Val Asp Phe Pro Gln Gln Ser His
        2675                2680                2685            
Trp Thr Gly Leu Leu Ser Glu Met Glu Leu Val Pro Ser Ile His Pro
    2690                2695                2700                
Gly Val Thr Cys Asp Gly Cys Gln Met Phe Pro Ile Asn Gly Ser Arg
2705                2710                2715                2720
Phe Lys Cys Arg Asn Cys Asp Asp Phe Asp Phe Cys Glu Thr Cys Phe
                2725                2730                2735    
Lys Thr Lys Lys His Asn Thr Arg His Thr Phe Gly Arg Ile Asn Glu
            2740                2745                2750        
Pro Gly Gln Ser Ala Val Phe Cys Gly Arg Ser Gly Lys Gln Leu Lys
        2755                2760                2765            
Arg Cys His Ser Ser Gln Pro Gly Met Leu Leu Asp Ser Trp Ser Arg
    2770                2775                2780                
Met Val Lys Ser Leu Asn Val Ser Ser Ser Val Asn Gln Ala Ser Arg
2785                2790                2795                2800
Leu Ile Asp Gly Ser Glu Pro Cys Trp Gln Ser Ser Gly Ser Gln Gly
                2805                2810                2815    
Lys His Trp Ile Arg Leu Glu Ile Phe Pro Asp Val Leu Val His Arg
            2820                2825                2830        
Leu Lys Met Ile Val Asp Pro Ala Asp Ser Ser Tyr Met Pro Ser Leu
        2835                2840                2845            
Val Val Val Ser Gly Gly Asn Ser Leu Asn Asn Leu Ile Glu Leu Lys
    2850                2855                2860                
Thr Ile Asn Ile Asn Pro Ser Asp Thr Thr Val Pro Leu Leu Asn Asp
2865                2870                2875                2880
Tyr Thr Glu Tyr His Arg Tyr Ile Glu Ile Ala Ile Lys Gln Cys Arg
                2885                2890                2895    
Ser Ser Gly Ile Asp Cys Lys Ile His Gly Leu Ile Leu Leu Gly Arg
            2900                2905                2910        
Ile Arg Ala Glu Glu Glu Asp Leu Ala Ala Val Pro Phe Leu Ala Ser
        2915                2920                2925            
Asp Asn Glu Glu Glu Glu Asp Glu Lys Gly Asn Ser Gly Ser Leu Ile
    2930                2935                2940                
Arg Lys Lys Ala Ala Gly Leu Glu Ser Ala Ala Thr Ile Arg Thr Lys
2945                2950                2955                2960
Val Phe Val Trp Gly Leu Asn Asp Lys Asp Gln Leu Gly Gly Leu Lys
                2965                2970                2975    
Gly Ser Lys Ile Lys Val Pro Ser Phe Ser Glu Thr Leu Ser Ala Leu
            2980                2985                2990        
Asn Val Val Gln Val Ala Gly Gly Ser Lys Ser Leu Phe Ala Val Thr
        2995                3000                3005            
Val Glu Gly Lys Val Tyr Ala Cys Gly Glu Ala Thr Asn Gly Arg Leu
    3010                3015                3020                
Gly Leu Gly Ile Ser Ser Gly Thr Val Pro Ile Pro Arg Gln Ile Thr
3025                3030                3035                3040
Ala Leu Ser Ser Tyr Val Val Lys Lys Val Ala Val His Ser Gly Gly
                3045                3050                3055    
Arg His Ala Thr Ala Leu Thr Val Asp Gly Lys Val Phe Ser Trp Gly
            3060                3065                3070        
Glu Gly Asp Asp Gly Lys Leu Gly His Phe Ser Arg Met Asn Cys Asp
        3075                3080                3085            
Lys Pro Arg Leu Ile Glu Ala Leu Lys Thr Lys Arg Ile Arg Asp Ile
    3090                3095                3100                
Ala Cys Gly Ser Ser His Ser Ala Ala Leu Thr Ser Ser Gly Glu Leu
3105                3110                3115                3120
Tyr Thr Trp Gly Leu Gly Glu Tyr Gly Arg Leu Gly His Gly Asp Asn
                3125                3130                3135    
Thr Thr Gln Leu Lys Pro Lys Met Val Lys Val Leu Leu Gly His Arg
            3140                3145                3150        
Val Ile Gln Val Ala Cys Gly Ser Arg Asp Ala Gln Thr Leu Ala Leu
        3155                3160                3165            
Thr Asp Glu Gly Leu Val Phe Ser Trp Gly Asp Gly Asp Phe Gly Lys
    3170                3175                3180                
Leu Gly Arg Gly Gly Ser Glu Gly Cys Asn Ile Pro Gln Asn Ile Glu
3185                3190                3195                3200
Arg Leu Asn Gly Gln Gly Val Cys Gln Ile Glu Cys Gly Ala Gln Phe
                3205                3210                3215    
Ser Leu Ala Leu Thr Lys Ser Gly Val Val Trp Thr Trp Gly Lys Gly
            3220                3225                3230        
Asp Tyr Phe Arg Leu Gly His Gly Ser Asp Val His Val Arg Lys Pro
        3235                3240                3245            
Gln Val Val Glu Gly Leu Arg Gly Lys Lys Ile Val His Val Ala Val
    3250                3255                3260                
Gly Ala Leu His Cys Leu Ala Val Thr Asp Ser Gly Gln Val Tyr Ala
3265                3270                3275                3280
Trp Gly Asp Asn Asp His Gly Gln Gln Gly Asn Gly Thr Thr Thr Val
                3285                3290                3295    
Asn Arg Lys Pro Thr Leu Val Gln Gly Leu Glu Gly Gln Lys Ile Thr
            3300                3305                3310        
Arg Val Ala Cys Gly Ser Ser His Ser Val Ala Trp Thr Thr Val Asp
        3315                3320                3325            
Val Ala Thr Pro Ser Val His Glu Pro Val Leu Phe Gln Thr Ala Arg
    3330                3335                3340                
Asp Pro Leu Gly Ala Ser Tyr Leu Gly Val Pro Ser Asp Ala Asp Ser
3345                3350                3355                3360
Ser Ala Ala Ser Asn Lys Ile Ser Gly Ala Ser Asn Ser Lys Pro Asn
                3365                3370                3375    
Arg Pro Ser Leu Ala Lys Ile Leu Leu Ser Leu Asp Gly Asn Leu Ala
            3380                3385                3390        
Lys Gln Gln Ala Leu Ser His Ile Leu Thr Ala Leu Gln Ile Met Tyr
        3395                3400                3405            
Ala Arg Asp Ala Val Val Gly Ala Leu Met Pro Ala Ala Met Ile Ala
    3410                3415                3420                
Pro Val Glu Cys Pro Ser Phe Ser Ser Ala Ala Pro Ser Asp Ala Ser
3425                3430                3435                3440
Ala Met Ala Ser Pro Met Asn Gly Glu Glu Cys Met Leu Ala Val Asp
                3445                3450                3455    
Ile Glu Asp Arg Leu Ser Pro Asn Pro Trp Gln Glu Lys Arg Glu Ile
            3460                3465                3470        
Val Ser Ser Glu Asp Ala Val Thr Pro Ser Ala Val Thr Pro Ser Ala
        3475                3480                3485            
Pro Ser Ala Ser Ala Arg Pro Phe Ile Pro Val Thr Asp Asp Leu Gly
    3490                3495                3500                
Ala Ala Ser Ile Ile Ala Glu Thr Met Thr Lys Thr Lys Glu Asp Val
3505                3510                3515                3520
Glu Ser Gln Asn Lys Ala Ala Gly Pro Glu Pro Gln Ala Leu Asp Glu
                3525                3530                3535    
Phe Thr Ser Leu Leu Ile Ala Asp Asp Thr Arg Val Val Val Asp Leu
            3540                3545                3550        
Leu Lys Leu Ser Val Cys Ser Arg Ala Gly Asp Arg Gly Arg Asp Val
        3555                3560                3565            
Leu Ser Ala Val Leu Ser Gly Met Gly Thr Ala Tyr Pro Gln Val Ala
    3570                3575                3580                
Asp Met Leu Leu Glu Leu Cys Val Thr Glu Leu Glu Asp Val Ala Thr
3585                3590                3595                3600
Asp Ser Gln Ser Gly Arg Leu Ser Ser Gln Pro Val Val Val Glu Ser
                3605                3610                3615    
Ser His Pro Tyr Thr Asp Asp Thr Ser Thr Ser Gly Thr Val Lys Ile
            3620                3625                3630        
Pro Gly Ala Glu Gly Leu Arg Val Glu Phe Asp Arg Gln Cys Ser Thr
        3635                3640                3645            
Glu Arg Arg His Asp Pro Leu Thr Val Met Asp Gly Val Asn Arg Ile
    3650                3655                3660                
Val Ser Val Arg Ser Gly Arg Glu Trp Ser Asp Trp Ser Ser Glu Leu
3665                3670                3675                3680
Arg Ile Pro Gly Asp Glu Leu Lys Trp Lys Phe Ile Ser Asp Gly Ser
                3685                3690                3695    
Val Asn Gly Trp Gly Trp Arg Phe Thr Val Tyr Pro Ile Met Pro Ala
            3700                3705                3710        
Ala Gly Pro Lys Glu Leu Leu Ser Asp Arg Cys Val Leu Ser Cys Pro
        3715                3720                3725            
Ser Met Asp Leu Val Thr Cys Leu Leu Asp Phe Arg Leu Asn Leu Ala
    3730                3735                3740                
Ser Asn Arg Ser Ile Val Pro Arg Leu Ala Ala Ser Leu Ala Ala Cys
3745                3750                3755                3760
Ala Gln Leu Ser Ala Leu Ala Ala Ser His Arg Met Trp Ala Leu Gln
                3765                3770                3775    
Arg Leu Arg Lys Leu Leu Thr Thr Glu Phe Gly Gln Ser Ile Asn Ile
            3780                3785                3790        
Asn Arg Leu Leu Gly Glu Asn Asp Gly Glu Thr Arg Ala Leu Ser Phe
        3795                3800                3805            
Thr Gly Ser Ala Leu Ala Ala Leu Val Lys Gly Leu Pro Glu Ala Leu
    3810                3815                3820                
Gln Arg Gln Phe Glu Tyr Glu Asp Pro Ile Val Arg Gly Gly Lys Gln
3825                3830                3835                3840
Leu Leu His Ser Pro Phe Phe Lys Val Leu Val Ala Leu Ala Cys Asp
                3845                3850                3855    
Leu Glu Leu Asp Thr Leu Pro Cys Cys Ala Glu Thr His Lys Trp Ala
            3860                3865                3870        
Trp Phe Arg Arg Tyr Cys Met Ala Ser Arg Val Ala Val Ala Leu Asp
        3875                3880                3885            
Lys Arg Thr Pro Leu Pro Arg Leu Phe Leu Asp Glu Val Ala Lys Lys
    3890                3895                3900                
Ile Arg Glu Leu Met Ala Asp Ser Glu Asn Met Asp Val Leu His Glu
3905                3910                3915                3920
Ser His Asp Ile Phe Lys Arg Glu Gln Asp Glu Gln Leu Val Gln Trp
                3925                3930                3935    
Met Asn Arg Arg Pro Asp Asp Trp Thr Leu Ser Ala Gly Gly Ser Gly
            3940                3945                3950        
Thr Ile Tyr Gly Trp Gly His Asn His Arg Gly Gln Leu Gly Gly Ile
        3955                3960                3965            
Glu Gly Ala Lys Val Lys Val Pro Thr Pro Cys Glu Ala Leu Ala Thr
    3970                3975                3980                
Leu Arg Pro Val Gln Leu Ile Gly Gly Glu Gln Thr Leu Phe Ala Val
3985                3990                3995                4000
Thr Ala Asp Gly Lys Leu Tyr Ala Thr Gly Tyr Gly Ala Gly Gly Arg
                4005                4010                4015    
Leu Gly Ile Gly Gly Thr Glu Ser Val Ser Thr Pro Thr Leu Leu Glu
            4020                4025                4030        
Ser Ile Gln His Val Phe Ile Lys Lys Val Ala Val Asn Ser Gly Gly
        4035                4040                4045            
Lys His Cys Leu Ala Leu Ser Ser Glu Gly Glu Val Tyr Ser Trp Gly
    4050                4055                4060                
Glu Ala Glu Asp Gly Lys Leu Gly His Gly Asn Arg Ser Pro Cys Asp
4065                4070                4075                4080
Arg Pro Arg Val Ile Glu Ser Leu Arg Gly Ile Glu Val Val Asp Val
                4085                4090                4095    
Ala Ala Gly Gly Ala His Ser Ala Cys Val Thr Ala Ala Gly Asp Leu
            4100                4105                4110        
Tyr Thr Trp Gly Lys Gly Arg Tyr Gly Arg Leu Gly His Ser Asp Ser
        4115                4120                4125            
Glu Asp Gln Leu Lys Pro Lys Leu Val Glu Ala Leu Gln Gly His Arg
    4130                4135                4140                
Val Val Asp Ile Ala Cys Gly Ser Gly Asp Ala Gln Thr Leu Cys Leu
4145                4150                4155                4160
Thr Asp Asp Asp Thr Val Trp Ser Trp Gly Asp Gly Asp Tyr Gly Lys
                4165                4170                4175    
Leu Gly Arg Gly Gly Ser Asp Gly Cys Lys Val Pro Met Lys Ile Asp
            4180                4185                4190        
Ser Leu Thr Gly Leu Gly Val Val Lys Val Glu Cys Gly Ser Gln Phe
        4195                4200                4205            
Ser Val Ala Leu Thr Lys Ser Gly Ala Val Tyr Thr Trp Gly Lys Gly
    4210                4215                4220                
Asp Tyr His Arg Leu Gly His Gly Ser Asp Asp His Val Arg Arg Pro
4225                4230                4235                4240
Arg Gln Val Gln Gly Leu Gln Gly Lys Lys Val Ile Ala Ile Ala Thr
                4245                4250                4255    
Gly Ser Leu His Cys Val Cys Cys Thr Glu Asp Gly Glu Val Tyr Thr
            4260                4265                4270        
Trp Gly Asp Asn Asp Glu Gly Gln Leu Gly Asp Gly Thr Thr Asn Ala
        4275                4280                4285            
Ile Gln Arg Pro Arg Leu Val Ala Ala Leu Gln Gly Lys Lys Val Asn
    4290                4295                4300                
Arg Val Ala Cys Gly Ser Ala His Thr Leu Ala Trp Ser Thr Ser Lys
4305                4310                4315                4320
Pro Ala Ser Ala Gly Lys Leu Pro Ala Gln Val Pro Met Glu Tyr Asn
                4325                4330                4335    
His Leu Gln Glu Ile Pro Ile Ile Ala Leu Arg Asn Arg Leu Leu Leu
            4340                4345                4350        
Leu His His Leu Ser Glu Leu Phe Cys Pro Cys Ile Pro Met Phe Asp
        4355                4360                4365            
Leu Glu Gly Ser Leu Asp Glu Thr Gly Leu Gly Pro Ser Val Gly Phe
    4370                4375                4380                
Asp Thr Leu Arg Gly Ile Leu Ile Ser Gln Gly Lys Glu Ala Ala Phe
4385                4390                4395                4400
Arg Lys Val Val Gln Ala Thr Met Val Arg Asp Arg Gln His Gly Pro
                4405                4410                4415    
Val Val Glu Leu Asn Arg Ile Gln Val Lys Arg Ser Arg Ser Lys Gly
            4420                4425                4430        
Gly Leu Ala Gly Pro Asp Gly Thr Lys Ser Val Phe Gly Gln Met Cys
        4435                4440                4445            
Ala Lys Met Ser Ser Phe Gly Pro Asp Ser Leu Leu Leu Pro His Arg
    4450                4455                4460                
Val Trp Lys Val Lys Phe Val Gly Glu Ser Val Asp Asp Cys Gly Gly
4465                4470                4475                4480
Gly Tyr Ser Glu Ser Ile Ala Glu Ile Cys Glu Glu Leu Gln Asn Gly
                4485                4490                4495    
Leu Thr Pro Leu Leu Ile Val Thr Pro Asn Gly Arg Asp Glu Ser Gly
            4500                4505                4510        
Ala Asn Arg Asp Cys Tyr Leu Leu Ser Pro Ala Ala Arg Ala Pro Val
        4515                4520                4525            
His Ser Ser Met Phe Arg Phe Leu Gly Val Leu Leu Gly Ile Ala Ile
    4530                4535                4540                
Arg Thr Gly Ser Pro Leu Ser Leu Asn Leu Ala Glu Pro Val Trp Lys
4545                4550                4555                4560
Gln Leu Ala Gly Met Ser Leu Thr Ile Ala Asp Leu Ser Glu Val Asp
                4565                4570                4575    
Lys Asp Phe Ile Pro Gly Leu Met Tyr Ile Arg Asp Asn Glu Ala Thr
            4580                4585                4590        
Ser Glu Glu Phe Glu Ala Met Ser Leu Pro Phe Thr Val Pro Ser Ala
        4595                4600                4605            
Ser Gly Gln Asp Ile Gln Leu Ser Ser Lys His Thr His Ile Thr Leu
    4610                4615                4620                
Asp Asn Arg Ala Glu Tyr Val Arg Leu Ala Ile Asn Tyr Arg Leu His
4625                4630                4635                4640
Glu Phe Asp Glu Gln Val Ala Ala Val Arg Glu Gly Met Ala Arg Val
                4645                4650                4655    
Val Pro Val Pro Leu Leu Ser Leu Phe Thr Gly Tyr Glu Leu Glu Thr
            4660                4665                4670        
Met Val Cys Gly Ser Pro Asp Ile Pro Leu His Leu Leu Lys Ser Val
        4675                4680                4685            
Ala Thr Tyr Lys Gly Ile Glu Pro Ser Ala Ser Leu Ile Gln Trp Phe
    4690                4695                4700                
Trp Glu Val Met Glu Ser Phe Ser Asn Thr Glu Arg Ser Leu Phe Leu
4705                4710                4715                4720
Arg Phe Val Trp Gly Arg Thr Arg Leu Pro Arg Thr Ile Ala Asp Phe
                4725                4730                4735    
Arg Gly Arg Asp Phe Val Ile Gln Val Leu Asp Lys Tyr Asn Pro Pro
            4740                4745                4750        
Asp His Phe Leu Pro Glu Ser Tyr Thr Cys Phe Phe Leu Leu Lys Leu
        4755                4760                4765            
Pro Arg Tyr Ser Cys Lys Gln Val Leu Glu Glu Lys Leu Lys Tyr Ala
    4770                4775                4780                
Ile His Phe Cys Lys Ser Ile Asp Thr Asp Asp Tyr Ala Arg Ile Ala
4785                4790                4795                4800
Leu Thr Gly Glu Pro Ala Ala Asp Asp Ser Ser Asp Asp Ser Asp Asn
                4805                4810                4815    
Glu Asp Val Asp Ser Phe Ala Ser Asp Ser Thr Gln Asp Tyr Leu Thr
            4820                4825                4830        
Gly His
        


<210> 592
<211> 679
<212> PRT
<213> Homo sapiens

<400> 592
Met Ile Ser Ala Ser Arg Ala Ala Ala Ala Arg Leu Val Gly Ala Ala
 1               5                  10                  15      
Ala Ser Arg Gly Pro Thr Ala Ala Arg His Gln Asp Ser Trp Asn Gly
            20                  25                  30          
Leu Ser His Glu Ala Phe Arg Leu Val Ser Arg Arg Asp Tyr Ala Ser
        35                  40                  45              
Glu Ala Ile Lys Gly Ala Val Val Gly Ile Asp Leu Gly Thr Thr Asn
    50                  55                  60                  
Ser Cys Val Ala Val Met Glu Gly Lys Gln Ala Lys Val Leu Glu Asn
65                  70                  75                  80  
Ala Glu Gly Ala Arg Thr Thr Pro Ser Val Val Ala Phe Thr Ala Asp
                85                  90                  95      
Gly Glu Arg Leu Val Gly Met Pro Ala Lys Arg Gln Ala Val Thr Asn
            100                 105                 110         
Pro Asn Asn Thr Phe Tyr Ala Thr Lys Arg Leu Ile Gly Arg Arg Tyr
        115                 120                 125             
Asp Asp Pro Glu Val Gln Lys Asp Ile Lys Asn Val Pro Phe Lys Ile
    130                 135                 140                 
Val Arg Ala Ser Asn Gly Asp Ala Trp Val Glu Ala His Gly Lys Leu
145                 150                 155                 160 
Tyr Ser Pro Ser Gln Ile Gly Ala Phe Val Leu Met Lys Met Lys Glu
                165                 170                 175     
Thr Ala Glu Asn Tyr Leu Gly His Thr Ala Lys Asn Ala Val Ile Thr
            180                 185                 190         
Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp Ala
        195                 200                 205             
Gly Gln Ile Ser Gly Leu Asn Val Leu Arg Val Ile Asn Glu Pro Thr
    210                 215                 220                 
Ala Ala Ala Leu Ala Tyr Gly Leu Asp Lys Ser Glu Asp Lys Val Ile
225                 230                 235                 240 
Ala Val Tyr Asp Leu Gly Gly Gly Thr Phe Asp Ile Ser Ile Leu Glu
                245                 250                 255     
Ile Gln Lys Gly Val Phe Glu Val Lys Ser Thr Asn Gly Asp Thr Phe
            260                 265                 270         
Leu Gly Gly Glu Asp Phe Asp Gln Ala Leu Leu Arg His Ile Val Lys
        275                 280                 285             
Glu Phe Lys Arg Glu Thr Gly Val Asp Leu Thr Lys Asp Asn Met Ala
    290                 295                 300                 
Leu Gln Arg Val Arg Glu Ala Ala Glu Lys Ala Lys Cys Glu Leu Ser
305                 310                 315                 320 
Ser Ser Val Gln Thr Asp Ile Asn Leu Pro Tyr Leu Thr Met Asp Ser
                325                 330                 335     
Ser Gly Pro Lys His Leu Asn Met Lys Leu Thr Arg Ala Gln Phe Glu
            340                 345                 350         
Gly Ile Val Thr Asp Leu Ile Arg Arg Thr Ile Ala Pro Cys Gln Lys
        355                 360                 365             
Ala Met Gln Asp Ala Glu Val Ser Lys Ser Asp Ile Gly Glu Val Ile
    370                 375                 380                 
Leu Val Gly Gly Met Thr Arg Met Pro Lys Val Gln Gln Thr Val Gln
385                 390                 395                 400 
Asp Leu Phe Gly Arg Ala Pro Ser Lys Ala Val Asn Pro Asp Glu Ala
                405                 410                 415     
Val Ala Ile Gly Ala Ala Ile Gln Gly Gly Val Leu Ala Gly Asp Val
            420                 425                 430         
Thr Asp Val Leu Leu Leu Asp Val Thr Pro Leu Ser Leu Gly Ile Glu
        435                 440                 445             
Thr Leu Gly Gly Val Phe Thr Lys Leu Ile Asn Arg Asn Thr Thr Ile
    450                 455                 460                 
Pro Thr Lys Lys Ser Gln Val Phe Ser Thr Ala Ala Asp Gly Gln Thr
465                 470                 475                 480 
Gln Val Glu Ile Lys Val Cys Gln Gly Glu Arg Glu Met Ala Gly Asp
                485                 490                 495     
Asn Lys Leu Leu Gly Gln Phe Thr Leu Ile Gly Ile Pro Pro Ala Pro
            500                 505                 510         
Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile Asp Ala Asn Gly
        515                 520                 525             
Ile Val His Val Ser Ala Lys Asp Lys Gly Thr Arg Arg Glu Gln Gln
    530                 535                 540                 
Ile Val Ile Gln Ser Ser Gly Gly Leu Ser Lys Asp Asp Ile Glu Asn
545                 550                 555                 560 
Met Val Lys Asn Ala Glu Lys Tyr Ala Glu Glu Asp Arg Arg Lys Lys
                565                 570                 575     
Glu Arg Val Glu Ala Val Asn Met Ala Glu Gly Ile Ile His Asp Thr
            580                 585                 590         
Glu Thr Lys Met Glu Glu Phe Lys Asp Gln Leu Pro Ala Asp Glu Cys
        595                 600                 605             
Asn Lys Leu Lys Glu Glu Ile Ser Lys Met Arg Glu Leu Leu Ala Arg
    610                 615                 620                 
Lys Asp Ser Glu Thr Gly Glu Asn Ile Arg Gln Ala Ala Ser Ser Leu
625                 630                 635                 640 
Gln Gln Ala Ser Leu Lys Leu Phe Glu Met Ala Tyr Lys Lys Met Ala
                645                 650                 655     
Ser Glu Arg Glu Gly Ser Gly Ser Ser Gly Thr Gly Glu Gln Lys Glu
            660                 665                 670         
Asp Gln Lys Glu Glu Lys Gln
        675                 


<210> 593
<211> 393
<212> PRT
<213> Homo sapiens

<400> 593
Met Ala Leu Lys Val Ala Thr Val Ala Gly Ser Ala Ala Lys Ala Val
 1               5                  10                  15      
Leu Gly Pro Ala Leu Leu Cys Arg Pro Trp Glu Val Leu Gly Ala His
            20                  25                  30          
Glu Val Pro Ser Arg Asn Ile Phe Ser Glu Gln Thr Ile Pro Pro Ser
        35                  40                  45              
Ala Lys Tyr Gly Gly Arg His Thr Val Thr Met Ile Pro Gly Asp Gly
    50                  55                  60                  
Ile Gly Pro Glu Leu Met Leu His Val Lys Ser Val Phe Arg His Ala
65                  70                  75                  80  
Cys Val Pro Val Asp Phe Glu Glu Val His Val Ser Ser Asn Ala Asp
                85                  90                  95      
Glu Glu Asp Ile Arg Asn Ala Ile Met Ala Ile Arg Arg Asn Arg Val
            100                 105                 110         
Ala Leu Lys Gly Asn Ile Glu Thr Asn His Asn Leu Pro Pro Ser His
        115                 120                 125             
Lys Ser Arg Asn Asn Ile Leu Arg Thr Ser Leu Asp Leu Tyr Ala Asn
    130                 135                 140                 
Val Ile His Cys Lys Ser Leu Pro Gly Val Val Thr Arg His Lys Asp
145                 150                 155                 160 
Ile Asp Ile Leu Ile Val Arg Glu Asn Thr Glu Gly Glu Tyr Ser Ser
                165                 170                 175     
Leu Glu His Glu Ser Val Ala Gly Val Val Glu Ser Leu Lys Ile Ile
            180                 185                 190         
Thr Lys Ala Lys Ser Leu Arg Ile Ala Glu Tyr Ala Phe Lys Leu Ala
        195                 200                 205             
Gln Glu Ser Gly Arg Lys Lys Val Thr Ala Val His Lys Ala Asn Ile
    210                 215                 220                 
Met Lys Leu Gly Asp Gly Leu Phe Leu Gln Cys Cys Arg Glu Val Ala
225                 230                 235                 240 
Ala Arg Tyr Pro Gln Ile Thr Phe Glu Asn Met Ile Val Asp Asn Thr
                245                 250                 255     
Thr Met Gln Leu Val Ser Arg Pro Gln Gln Phe Asp Val Met Val Met
            260                 265                 270         
Pro Asn Leu Tyr Gly Asn Ile Val Asn Asn Val Cys Ala Gly Leu Val
        275                 280                 285             
Gly Gly Pro Gly Leu Val Ala Gly Ala Asn Tyr Gly His Val Tyr Ala
    290                 295                 300                 
Val Phe Glu Thr Ala Thr Arg Asn Thr Gly Lys Ser Ile Ala Asn Lys
305                 310                 315                 320 
Asn Ile Ala Asn Pro Thr Ala Thr Leu Leu Ala Ser Cys Met Met Leu
                325                 330                 335     
Asp His Leu Lys Leu His Ser Tyr Ala Thr Ser Ile Arg Lys Ala Val
            340                 345                 350         
Leu Ala Ser Met Asp Asn Glu Asn Met His Thr Pro Asp Ile Gly Gly
        355                 360                 365             
Gln Gly Thr Thr Ser Glu Ala Ile Gln Asp Val Ile Arg His Ile Arg
    370                 375                 380                 
Val Ile Asn Gly Arg Ala Val Glu Ala
385                 390             


<210> 594
<211> 671
<212> PRT
<213> Homo sapiens

<400> 594
Met Arg Pro Met Arg Ile Phe Val Asn Asp Asp Arg His Val Met Ala
 1               5                  10                  15      
Lys His Ser Ser Val Tyr Pro Thr Gln Glu Glu Leu Glu Ala Val Gln
            20                  25                  30          
Asn Met Val Ser His Thr Glu Arg Ala Leu Lys Ala Val Ser Asp Trp
        35                  40                  45              
Ile His Glu Gln Glu Lys Gly Ser Ser Glu Gln Ala Glu Ser Asp Asn
    50                  55                  60                  
Met Asp Val Pro Pro Glu Asp Asp Ser Lys Glu Gly Ala Gly Glu Gln
65                  70                  75                  80  
Lys Thr Glu His Met Thr Arg Thr Cys Arg Gly Val Met Arg Ala Gly
                85                  90                  95      
Pro Gly Gly Gln Ser Ala Ser Tyr Ser Arg Gly Thr Trp Ile Trp Ser
            100                 105                 110         
Trp Cys Cys Cys Val Arg Arg Ser Pro Gln Pro Ala Leu Leu Asp Lys
        115                 120                 125             
Val Ala Asp Asn Leu Ala Ile Gln Leu Ala Ala Val Thr Glu Asp Lys
    130                 135                 140                 
Tyr Glu Ile Leu Gln Ser Val Asp Asp Ala Ala Ile Val Ile Lys Asn
145                 150                 155                 160 
Thr Lys Glu Pro Pro Leu Ser Leu Thr Ile His Leu Thr Ser Pro Val
                165                 170                 175     
Val Arg Glu Glu Met Glu Lys Val Leu Ala Gly Glu Thr Leu Ser Val
            180                 185                 190         
Asn Asp Pro Pro Asp Val Leu Asp Arg Gln Lys Cys Phe Ala Ala Leu
        195                 200                 205             
Ala Ser Leu Arg His Ala Lys Trp Phe Gln Ala Arg Ala Asn Gly Leu
    210                 215                 220                 
Lys Ser Cys Val Ile Val Ile Arg Val Leu Arg Asp Leu Cys Thr Arg
225                 230                 235                 240 
Val Pro Thr Trp Gly Pro Leu Arg Gly Trp Pro Leu Glu Leu Leu Cys
                245                 250                 255     
Glu Lys Ser Ile Gly Thr Ala Asn Arg Pro Met Gly Ala Gly Glu Ala
            260                 265                 270         
Leu Arg Arg Val Leu Glu Cys Leu Ala Ser Gly Ile Val Met Pro Asp
        275                 280                 285             
Gly Ser Gly Ile Tyr Asp Pro Cys Glu Lys Glu Ala Thr Asp Ala Ile
    290                 295                 300                 
Gly His Leu Asp Arg Gln Gln Arg Glu Asp Ile Thr Gln Ser Ala Gln
305                 310                 315                 320 
His Ala Leu Arg Leu Ala Ala Phe Gly Gln Leu His Lys Val Leu Gly
                325                 330                 335     
Met Asp Pro Leu Pro Ser Lys Met Pro Lys Lys Pro Lys Asn Glu Asn
            340                 345                 350         
Pro Val Asp Tyr Thr Val Gln Ile Pro Pro Ser Thr Thr Tyr Ala Ile
        355                 360                 365             
Thr Pro Met Lys Arg Pro Met Glu Glu Asp Gly Glu Glu Lys Ser Pro
    370                 375                 380                 
Ser Lys Lys Lys Lys Lys Ile Gln Lys Lys Glu Glu Lys Ala Glu Pro
385                 390                 395                 400 
Pro Gln Ala Met Asn Ala Leu Met Arg Leu Asn Gln Leu Lys Pro Gly
                405                 410                 415     
Leu Gln Tyr Lys Leu Val Ser Gln Thr Gly Pro Val His Ala Pro Ile
            420                 425                 430         
Phe Thr Met Ser Val Glu Val Asp Gly Asn Ser Phe Glu Ala Ser Gly
        435                 440                 445             
Pro Ser Lys Lys Thr Ala Lys Leu His Val Ala Val Lys Val Leu Gln
    450                 455                 460                 
Asp Met Gly Leu Pro Thr Gly Ala Glu Gly Arg Asp Ser Ser Lys Gly
465                 470                 475                 480 
Glu Asp Ser Ala Glu Glu Thr Glu Ala Lys Pro Ala Val Val Ala Pro
                485                 490                 495     
Ala Pro Val Val Glu Ala Val Ser Thr Pro Ser Ala Ala Phe Pro Ser
            500                 505                 510         
Asp Ala Thr Ala Glu Asn Val Lys Gln Gln Gly Pro Ile Leu Thr Lys
        515                 520                 525             
His Gly Lys Asn Pro Val Met Glu Leu Asn Glu Lys Arg Arg Gly Leu
    530                 535                 540                 
Lys Tyr Glu Leu Ile Ser Glu Thr Gly Gly Ser His Asp Lys Arg Phe
545                 550                 555                 560 
Val Met Glu Val Glu Val Asp Gly Gln Lys Phe Gln Gly Ala Gly Ser
                565                 570                 575     
Asn Lys Lys Val Ala Lys Ala Tyr Ala Ala Leu Ala Ala Leu Glu Lys
            580                 585                 590         
Leu Phe Pro Asp Thr Pro Leu Ser Pro Leu Met Pro Thr Lys Arg Arg
        595                 600                 605             
Glu Pro Gln Tyr Pro Ser Glu Gly Asp Arg Asn Leu Leu Leu Ser His
    610                 615                 620                 
Ile Thr Leu Ala Ser Ala Trp Glu Ala Pro Cys Thr Thr Lys Cys Pro
625                 630                 635                 640 
His Pro Pro Thr Phe Glu Gly Gly Glu Glu Ala Gly Arg Ser Gly Asp
                645                 650                 655     
Glu Gly Ala Gly Glu Asp Leu Val Ala Pro Thr Met Glu Ala Thr
            660                 665                 670     


<210> 595
<211> 756
<212> PRT
<213> Homo sapiens

<400> 595
Met Leu Gly Ile Cys Arg Gly Arg Arg Lys Phe Leu Ala Ala Ser Leu
 1               5                  10                  15      
Ser Leu Leu Cys Ile Pro Ala Ile Thr Trp Ile Tyr Leu Phe Ser Gly
            20                  25                  30          
Ser Phe Glu Asp Gly Lys Pro Val Ser Leu Ser Pro Leu Glu Ser Gln
        35                  40                  45              
Ala His Ser Pro Arg Tyr Thr Ala Ser Ser Gln Arg Glu Arg Glu Ser
    50                  55                  60                  
Leu Glu Val Arg Met Arg Glu Val Glu Glu Glu Asn Arg Ala Leu Arg
65                  70                  75                  80  
Arg Gln Leu Ser Leu Ala Gln Gly Arg Ala Pro Ser His Arg Arg Gly
                85                  90                  95      
Asn His Ser Lys Thr Tyr Ser Met Glu Glu Gly Thr Gly Asp Ser Glu
            100                 105                 110         
Asn Leu Arg Ala Gly Ile Val Ala Gly Asn Ser Ser Glu Cys Gly Gln
        115                 120                 125             
Gln Pro Val Val Glu Lys Cys Glu Thr Ile His Val Ala Ile Val Cys
    130                 135                 140                 
Ala Gly Tyr Asn Ala Ser Arg Asp Val Val Thr Leu Val Lys Ser Val
145                 150                 155                 160 
Leu Phe His Arg Arg Asn Pro Leu His Phe His Leu Ile Ala Asp Ser
                165                 170                 175     
Ile Ala Glu Gln Ile Leu Ala Thr Leu Phe Gln Thr Trp Met Val Pro
            180                 185                 190         
Ala Val Arg Val Asp Phe Tyr Asn Ala Asp Glu Leu Lys Ser Glu Val
        195                 200                 205             
Ser Trp Ile Pro Asn Lys His Tyr Ser Gly Ile Tyr Gly Leu Met Lys
    210                 215                 220                 
Leu Val Leu Thr Lys Thr Leu Pro Ala Asn Leu Glu Arg Val Ile Val
225                 230                 235                 240 
Leu Asp Thr Asp Ile Thr Phe Ala Thr Asp Ile Ala Glu Leu Trp Ala
                245                 250                 255     
Val Phe His Lys Phe Lys Gly Gln Gln Val Leu Gly Leu Val Glu Asn
            260                 265                 270         
Gln Ser Asp Trp Tyr Leu Gly Asn Leu Trp Lys Asn His Arg Pro Trp
        275                 280                 285             
Pro Ala Leu Gly Arg Gly Tyr Asn Thr Gly Val Ile Leu Leu Leu Leu
    290                 295                 300                 
Asp Lys Leu Arg Lys Met Lys Trp Glu Gln Met Trp Arg Leu Thr Ala
305                 310                 315                 320 
Glu Arg Glu Leu Met Gly Met Leu Ser Thr Ser Leu Ala Asp Gln Asp
                325                 330                 335     
Ile Phe Asn Ala Val Ile Lys Gln Asn Pro Phe Leu Val Tyr Gln Leu
            340                 345                 350         
Pro Cys Phe Trp Asn Val Gln Leu Ser Asp His Thr Arg Ser Glu Gln
        355                 360                 365             
Cys Tyr Arg Asp Val Ser Asp Leu Lys Val Ile His Trp Asn Ser Pro
    370                 375                 380                 
Lys Lys Leu Arg Val Lys Asn Lys His Val Glu Phe Phe Arg Asn Leu
385                 390                 395                 400 
Tyr Leu Thr Phe Leu Glu Tyr Asp Gly Asn Leu Leu Arg Arg Glu Leu
                405                 410                 415     
Phe Gly Cys Pro Ser Glu Ala Asp Val Asn Ser Glu Asn Leu Gln Lys
            420                 425                 430         
Gln Leu Ser Glu Leu Asp Glu Asp Asp Leu Cys Tyr Glu Phe Arg Arg
        435                 440                 445             
Glu Arg Phe Thr Val His Arg Thr His Leu Tyr Phe Leu His Tyr Glu
    450                 455                 460                 
Tyr Glu Pro Ala Ala Asp Ser Thr Asp Val Thr Leu Val Ala Gln Leu
465                 470                 475                 480 
Ser Met Asp Arg Leu Gln Met Leu Glu Ala Ile Cys Lys His Trp Glu
                485                 490                 495     
Gly Pro Ile Ser Leu Ala Leu Tyr Leu Ser Asp Ala Glu Ala Gln Gln
            500                 505                 510         
Phe Leu Arg Tyr Ala Gln Gly Ser Glu Val Leu Met Ser Arg His Asn
        515                 520                 525             
Val Gly Tyr His Ile Val Tyr Lys Glu Gly Gln Phe Tyr Pro Val Asn
    530                 535                 540                 
Leu Leu Arg Asn Val Ala Met Lys His Ile Ser Thr Pro Tyr Met Phe
545                 550                 555                 560 
Leu Ser Asp Ile Asp Phe Leu Pro Met Tyr Gly Leu Tyr Glu Tyr Leu
                565                 570                 575     
Arg Lys Ser Val Ile Gln Leu Asp Leu Ala Asn Thr Lys Lys Ala Met
            580                 585                 590         
Ile Val Pro Ala Phe Glu Thr Leu Arg Tyr Arg Leu Ser Phe Pro Lys
        595                 600                 605             
Ser Lys Ala Glu Leu Leu Ser Met Leu Asp Met Gly Thr Leu Phe Thr
    610                 615                 620                 
Phe Arg Tyr His Val Trp Thr Lys Gly His Ala Pro Thr Asn Phe Ala
625                 630                 635                 640 
Lys Trp Arg Thr Ala Thr Thr Pro Tyr Arg Val Glu Trp Glu Ala Asp
                645                 650                 655     
Phe Glu Pro Tyr Val Val Val Arg Arg Asp Cys Pro Glu Tyr Asp Arg
            660                 665                 670         
Arg Phe Val Gly Phe Gly Trp Asn Lys Val Ala His Ile Met Glu Leu
        675                 680                 685             
Asp Val Gln Glu Tyr Glu Phe Ile Val Leu Pro Asn Ala Tyr Met Ile
    690                 695                 700                 
His Met Pro His Ala Pro Ser Phe Asp Ile Thr Lys Phe Arg Ser Asn
705                 710                 715                 720 
Lys Gln Tyr Arg Ile Cys Leu Lys Thr Leu Lys Glu Glu Phe Gln Gln
                725                 730                 735     
Asp Met Ser Arg Arg Tyr Gly Phe Ala Ala Leu Lys Tyr Leu Thr Ala
            740                 745                 750         
Glu Asn Asn Ser
        755     


<210> 596
<211> 937
<212> PRT
<213> Homo sapiens

<400> 596
Met Leu Ala Ala Ala Gly Gly Arg Val Pro Thr Ala Ala Gly Ala Trp
 1               5                  10                  15      
Leu Leu Arg Gly Gln Arg Thr Cys Asp Ala Ser Pro Pro Trp Ala Leu
            20                  25                  30          
Trp Gly Arg Gly Pro Ala Ile Gly Gly Gln Trp Arg Gly Phe Trp Glu
        35                  40                  45              
Ala Ser Ser Arg Gly Gly Gly Ala Phe Ser Gly Gly Glu Asp Ala Ser
    50                  55                  60                  
Glu Gly Gly Ala Glu Glu Gly Ala Gly Gly Ala Gly Gly Ser Ala Gly
65                  70                  75                  80  
Ala Gly Glu Gly Pro Val Ile Thr Ala Leu Thr Pro Met Thr Ile Pro
                85                  90                  95      
Asp Val Phe Pro His Leu Pro Leu Ile Ala Ile Thr Arg Asn Pro Val
            100                 105                 110         
Phe Pro Arg Phe Ile Lys Ile Ile Glu Val Lys Asn Lys Lys Leu Val
        115                 120                 125             
Glu Leu Leu Arg Arg Lys Val Arg Leu Ala Gln Pro Tyr Val Gly Val
    130                 135                 140                 
Phe Leu Lys Arg Asp Asp Ser Asn Glu Ser Asp Val Val Glu Ser Leu
145                 150                 155                 160 
Asp Glu Ile Tyr His Thr Gly Thr Phe Ala Gln Ile His Glu Met Gln
                165                 170                 175     
Asp Leu Gly Asp Lys Leu Arg Met Ile Val Met Gly His Arg Arg Val
            180                 185                 190         
His Ile Ser Arg Gln Leu Glu Val Glu Pro Glu Glu Pro Glu Ala Glu
        195                 200                 205             
Asn Lys His Lys Pro Arg Arg Lys Ser Lys Arg Gly Lys Lys Glu Ala
    210                 215                 220                 
Glu Asp Glu Leu Ser Ala Arg His Pro Ala Glu Leu Ala Met Glu Pro
225                 230                 235                 240 
Thr Pro Glu Leu Pro Ala Glu Val Leu Met Val Glu Val Glu Asn Val
                245                 250                 255     
Val His Glu Asp Phe Gln Val Thr Glu Glu Val Lys Ala Leu Thr Ala
            260                 265                 270         
Glu Ile Val Lys Thr Ile Arg Asp Ile Ile Ala Leu Asn Pro Leu Tyr
        275                 280                 285             
Arg Glu Ser Val Leu Gln Met Met Gln Ala Gly Gln Arg Val Val Asp
    290                 295                 300                 
Asn Pro Ile Tyr Leu Ser Asp Met Gly Ala Ala Leu Thr Gly Ala Glu
305                 310                 315                 320 
Ser His Glu Leu Gln Asp Val Leu Glu Glu Thr Asn Ile Pro Lys Arg
                325                 330                 335     
Leu Tyr Lys Ala Leu Ser Leu Leu Lys Lys Glu Phe Glu Leu Ser Lys
            340                 345                 350         
Leu Gln Gln Arg Leu Gly Arg Glu Val Glu Glu Lys Ile Lys Gln Thr
        355                 360                 365             
His Arg Lys Tyr Leu Leu Gln Glu Gln Leu Lys Ile Ile Lys Lys Glu
    370                 375                 380                 
Leu Gly Leu Glu Lys Asp Asp Lys Asp Ala Ile Glu Glu Lys Phe Arg
385                 390                 395                 400 
Glu Arg Leu Lys Glu Leu Val Val Pro Lys His Val Met Asp Val Val
                405                 410                 415     
Asp Glu Glu Leu Ser Lys Leu Gly Leu Leu Asp Asn His Ser Ser Glu
            420                 425                 430         
Phe Asn Val Thr Arg Asn Tyr Leu Asp Trp Leu Thr Ser Ile Pro Trp
        435                 440                 445             
Gly Lys Tyr Ser Asn Glu Asn Leu Asp Leu Ala Arg Ala Gln Ala Val
    450                 455                 460                 
Leu Glu Glu Asp His Tyr Gly Met Glu Asp Val Lys Lys Arg Ile Leu
465                 470                 475                 480 
Glu Phe Ile Ala Val Ser Gln Leu Arg Gly Ser Thr Gln Gly Lys Ile
                485                 490                 495     
Leu Cys Phe Tyr Gly Pro Pro Gly Val Gly Lys Thr Ser Ile Ala Arg
            500                 505                 510         
Ser Ile Ala Arg Ala Leu Asn Arg Glu Tyr Phe Arg Phe Ser Val Gly
        515                 520                 525             
Gly Met Thr Asp Val Ala Glu Ile Lys Gly His Arg Arg Thr Tyr Val
    530                 535                 540                 
Gly Ala Met Pro Gly Lys Ile Ile Gln Cys Leu Lys Lys Thr Lys Thr
545                 550                 555                 560 
Glu Asn Pro Leu Ile Leu Ile Asp Glu Val Asp Lys Ile Gly Arg Gly
                565                 570                 575     
Tyr Gln Gly Asp Pro Ser Ser Ala Leu Leu Glu Leu Leu Asp Pro Glu
            580                 585                 590         
Gln Asn Ala Asn Phe Leu Asp His Tyr Leu Asp Val Pro Val Asp Leu
        595                 600                 605             
Ser Lys Val Leu Phe Ile Cys Thr Ala Asn Val Thr Asp Thr Ile Pro
    610                 615                 620                 
Glu Pro Leu Arg Asp Arg Met Glu Met Ile Asn Val Ser Gly Tyr Val
625                 630                 635                 640 
Ala Gln Glu Lys Leu Ala Ile Ala Glu Arg Tyr Leu Val Pro Gln Ala
                645                 650                 655     
Arg Ala Leu Cys Gly Leu Asp Glu Ser Lys Ala Lys Leu Ser Ser Asp
            660                 665                 670         
Val Leu Thr Leu Leu Ile Lys Gln Tyr Cys Arg Glu Ser Gly Val Arg
        675                 680                 685             
Asn Leu Gln Lys Gln Val Glu Lys Val Leu Arg Lys Ser Ala Tyr Lys
    690                 695                 700                 
Ile Val Ser Gly Glu Ala Glu Ser Val Glu Val Thr Pro Glu Asn Leu
705                 710                 715                 720 
Gln Asp Phe Val Gly Lys Pro Val Phe Thr Val Glu Arg Met Tyr Asp
                725                 730                 735     
Val Thr Pro Pro Gly Val Val Met Gly Leu Ala Trp Thr Ala Met Gly
            740                 745                 750         
Gly Ser Thr Leu Phe Val Glu Thr Ser Leu Arg Arg Pro Gln Asp Lys
        755                 760                 765             
Asp Ala Lys Gly Asp Lys Asp Gly Ser Leu Glu Val Thr Gly Gln Leu
    770                 775                 780                 
Gly Glu Val Met Lys Glu Ser Ala Arg Ile Ala Tyr Thr Phe Ala Arg
785                 790                 795                 800 
Ala Phe Leu Met Gln His Ala Pro Ala Asn Asp Tyr Leu Val Thr Ser
                805                 810                 815     
His Ile His Leu His Val Pro Glu Gly Ala Thr Pro Lys Asp Gly Pro
            820                 825                 830         
Ser Ala Gly Cys Thr Ile Val Thr Ala Leu Leu Ser Leu Ala Met Gly
        835                 840                 845             
Arg Pro Val Arg Gln Asn Leu Ala Met Thr Gly Glu Val Ser Leu Thr
    850                 855                 860                 
Gly Lys Ile Leu Pro Val Gly Gly Ile Lys Glu Lys Thr Ile Ala Ala
865                 870                 875                 880 
Lys Arg Ala Gly Val Thr Cys Ile Ile Leu Pro Ala Glu Asn Lys Lys
                885                 890                 895     
Asp Phe Tyr Asp Leu Ala Ala Phe Ile Thr Glu Gly Leu Glu Val His
            900                 905                 910         
Phe Val Glu His Tyr Arg Glu Ile Phe Asp Ile Ala Phe Pro Asp Glu
        915                 920                 925             
Gln Ala Glu Ala Leu Ala Val Glu Arg
    930                 935         


<210> 597
<211> 152
<212> PRT
<213> Homo sapiens

<400> 597
Met Ala Val Leu Ser Lys Glu Tyr Gly Phe Val Leu Leu Thr Gly Ala
 1               5                  10                  15      
Ala Ser Phe Ile Met Val Ala His Leu Ala Ile Asn Val Ser Lys Ala
            20                  25                  30          
Arg Lys Lys Tyr Lys Val Glu Tyr Pro Ile Met Tyr Ser Thr Asp Pro
        35                  40                  45              
Glu Asn Gly His Ile Phe Asn Cys Ile Gln Arg Ala His Gln Asn Thr
    50                  55                  60                  
Leu Glu Val Tyr Pro Pro Phe Leu Phe Phe Leu Ala Val Gly Gly Val
65                  70                  75                  80  
Tyr His Pro Arg Ile Ala Ser Gly Leu Gly Leu Ala Trp Ile Val Gly
                85                  90                  95      
Arg Val Leu Tyr Ala Tyr Gly Tyr Tyr Thr Gly Glu Pro Ser Lys Arg
            100                 105                 110         
Ser Arg Gly Ala Leu Gly Ser Ile Ala Leu Leu Gly Leu Val Gly Thr
        115                 120                 125             
Thr Val Cys Ser Ala Phe Gln His Leu Gly Trp Val Lys Ser Gly Leu
    130                 135                 140                 
Gly Ser Gly Pro Lys Cys Cys His
145                 150         


<210> 598
<211> 2022
<212> PRT
<213> Homo sapiens

<400> 598
Met Ser Val Lys Glu Ala Gly Ser Ser Gly Arg Arg Glu Gln Ala Ala
 1               5                  10                  15      
Tyr His Leu His Ile Tyr Pro Gln Leu Ser Thr Thr Glu Ser Gln Ala
            20                  25                  30          
Ser Cys Arg Val Thr Ala Thr Lys Asp Ser Thr Thr Ser Asp Val Ile
        35                  40                  45              
Lys Asp Ala Ile Ala Ser Leu Arg Leu Asp Gly Thr Lys Cys Tyr Val
    50                  55                  60                  
Leu Val Glu Val Lys Glu Ser Gly Gly Glu Glu Trp Val Leu Asp Ala
65                  70                  75                  80  
Asn Asp Ser Pro Val His Arg Val Leu Leu Trp Pro Arg Arg Ala Gln
                85                  90                  95      
Asp Glu His Pro Gln Glu Asp Gly Tyr Tyr Phe Leu Leu Gln Glu Arg
            100                 105                 110         
Asn Ala Asp Gly Thr Ile Lys Tyr Val His Met Gln Leu Val Ala Gln
        115                 120                 125             
Ala Thr Ala Thr Arg Arg Leu Val Glu Arg Gly Leu Leu Pro Arg Gln
    130                 135                 140                 
Gln Ala Asp Phe Asp Asp Leu Cys Asn Leu Pro Glu Leu Thr Glu Gly
145                 150                 155                 160 
Asn Leu Leu Lys Asn Leu Lys His Arg Phe Leu Gln Gln Lys Ile Tyr
                165                 170                 175     
Thr Tyr Ala Gly Ser Ile Leu Val Ala Ile Asn Pro Phe Lys Phe Leu
            180                 185                 190         
Pro Ile Tyr Asn Pro Lys Tyr Val Lys Met Tyr Glu Asn Gln Gln Leu
        195                 200                 205             
Gly Lys Leu Glu Pro His Val Phe Ala Leu Ala Asp Val Ala Tyr Tyr
    210                 215                 220                 
Thr Met Leu Arg Lys Arg Val Asn Gln Cys Ile Val Tyr Pro Gly Glu
225                 230                 235                 240 
Ser Gly Ser Gly Lys Thr Gln Ser Thr Asn Phe Leu Ile His Cys Leu
                245                 250                 255     
Thr Ala Leu Ser Gln Lys Gly Tyr Ala Ser Gly Val Glu Arg Thr Ile
            260                 265                 270         
Leu Gly Ala Cys Pro Val Leu Glu Ala Phe Gly Asn Ala Lys Thr Ala
        275                 280                 285             
His Asn Asn Asn Ser Ser Arg Phe Gly Lys Phe Ile Gln Val Ser Tyr
    290                 295                 300                 
Leu Glu Ser Gly Ile Val Arg Gly Ala Val Val Glu Lys Tyr Leu Leu
305                 310                 315                 320 
Glu Lys Ser Arg Leu Val Ser Gln Glu Lys Asp Glu Arg Asn Tyr His
                325                 330                 335     
Val Phe Tyr Tyr Leu Leu Leu Gly Val Ser Glu Glu Glu Arg Gln Glu
            340                 345                 350         
Phe Gln Leu Lys Gln Pro Glu Asp Tyr Phe Tyr Leu Asn Gln His Asn
        355                 360                 365             
Leu Lys Ile Glu Asp Gly Glu Asp Leu Lys His Asp Phe Glu Arg Leu
    370                 375                 380                 
Lys Gln Ala Met Glu Met Val Gly Phe Leu Pro Ala Thr Lys Lys Gln
385                 390                 395                 400 
Ile Phe Ala Val Leu Ser Ala Ile Leu Tyr Leu Gly Asn Val Thr Tyr
                405                 410                 415     
Lys Lys Arg Ala Thr Gly Arg Glu Glu Gly Leu Glu Val Gly Pro Pro
            420                 425                 430         
Glu Val Leu Asp Thr Leu Ser Gln Leu Leu Lys Val Lys Arg Glu Ile
        435                 440                 445             
Leu Val Glu Val Leu Thr Lys Arg Lys Thr Val Thr Val Asn Asp Lys
    450                 455                 460                 
Leu Ile Leu Pro Tyr Ser Leu Ser Glu Ala Ile Thr Ala Arg Asp Ser
465                 470                 475                 480 
Met Ala Lys Ser Leu Tyr Ser Ala Leu Phe Asp Trp Ile Val Leu Arg
                485                 490                 495     
Ile Asn His Ala Leu Leu Asn Lys Lys Asp Val Glu Glu Ala Val Ser
            500                 505                 510         
Cys Leu Ser Ile Gly Val Leu Asp Ile Phe Gly Phe Glu Asp Phe Glu
        515                 520                 525             
Arg Asn Ser Phe Glu Gln Phe Cys Ile Asn Tyr Ala Asn Glu Gln Leu
    530                 535                 540                 
Gln Tyr Tyr Phe Asn Gln His Ile Phe Lys Leu Glu Gln Glu Glu Tyr
545                 550                 555                 560 
Gln Gly Glu Gly Ile Thr Trp His Asn Ile Gly Tyr Thr Asp Asn Val
                565                 570                 575     
Gly Cys Ile His Leu Ile Ser Lys Lys Pro Thr Gly Leu Phe Tyr Leu
            580                 585                 590         
Leu Asp Glu Glu Ser Asn Phe Pro His Ala Thr Ser Gln Thr Leu Leu
        595                 600                 605             
Ala Lys Phe Lys Gln Gln His Glu Asp Asn Lys Tyr Phe Leu Gly Thr
    610                 615                 620                 
Pro Val Met Glu Pro Ala Phe Ile Ile Gln His Phe Ala Gly Lys Val
625                 630                 635                 640 
Lys Tyr Gln Ile Lys Asp Phe Arg Glu Lys Asn Met Asp Tyr Met Arg
                645                 650                 655     
Pro Asp Ile Val Ala Leu Leu Arg Gly Ser Asp Ser Ser Tyr Val Arg
            660                 665                 670         
Glu Leu Ile Gly Met Asp Pro Val Ala Val Phe Arg Trp Ala Val Leu
        675                 680                 685             
Arg Ala Ala Ile Arg Ala Met Ala Val Leu Arg Glu Ala Gly Arg Leu
    690                 695                 700                 
Arg Ala Glu Arg Ala Glu Lys Ala Ala Gly Met Ser Ser Pro Gly Ala
705                 710                 715                 720 
Gln Ser His Pro Glu Glu Leu Pro Arg Gly Ala Ser Thr Pro Ser Glu
                725                 730                 735     
Lys Leu Tyr Arg Asp Leu His Asn Gln Met Ile Lys Ser Ile Lys Gly
            740                 745                 750         
Leu Pro Trp Gln Gly Glu Asp Pro Arg Ser Leu Leu Gln Ser Leu Ser
        755                 760                 765             
Arg Leu Gln Lys Pro Arg Ala Phe Ile Leu Lys Ser Lys Gly Ile Lys
    770                 775                 780                 
Gln Lys Gln Ile Ile Pro Lys Asn Leu Leu Asp Ser Lys Ser Leu Lys
785                 790                 795                 800 
Leu Ile Ile Ser Met Thr Leu His Asp Arg Thr Thr Lys Ser Leu Leu
                805                 810                 815     
His Leu His Lys Lys Lys Lys Pro Pro Ser Ile Ser Ala Gln Phe Gln
            820                 825                 830         
Thr Ser Leu Asn Lys Leu Leu Glu Ala Leu Gly Lys Ala Glu Pro Phe
        835                 840                 845             
Phe Ile Arg Cys Ile Arg Ser Asn Ala Glu Lys Lys Glu Leu Cys Phe
    850                 855                 860                 
Asp Asp Glu Leu Val Leu Gln Gln Leu Arg Tyr Thr Gly Met Leu Glu
865                 870                 875                 880 
Thr Val Arg Ile Arg Arg Ser Gly Tyr Ser Ala Lys Tyr Thr Phe Gln
                885                 890                 895     
Asp Phe Thr Glu Gln Phe Gln Val Leu Leu Pro Lys Asp Ala Gln Pro
            900                 905                 910         
Cys Arg Glu Val Ile Ser Thr Leu Leu Glu Lys Met Lys Ile Asp Lys
        915                 920                 925             
Arg Asn Tyr Gln Ile Gly Lys Thr Lys Val Phe Leu Lys Glu Thr Glu
    930                 935                 940                 
Arg Gln Ala Leu Gln Glu Thr Leu His Arg Glu Val Val Arg Lys Ile
945                 950                 955                 960 
Leu Leu Leu Gln Ser Trp Phe Arg Met Val Leu Glu Arg Arg His Phe
                965                 970                 975     
Leu Gln Met Lys Arg Ala Ala Val Thr Ile Gln Ala Cys Trp Arg Ser
            980                 985                 990         
Tyr Arg Val Arg Arg Ala Leu Glu Arg Thr Gln Ala Ala Val Tyr Leu
        995                 1000                1005            
Gln Ala Ala Trp Arg Gly Tyr Trp Gln Arg Lys Leu Tyr Arg His Gln
    1010                1015                1020                
Lys Gln Ser Ile Ile Arg Leu Gln Ser Leu Cys Arg Gly His Leu Gln
1025                1030                1035                1040
Arg Lys Ser Phe Ser Gln Met Ile Ser Glu Lys Gln Lys Ala Glu Glu
                1045                1050                1055    
Lys Glu Arg Glu Ala Leu Glu Ala Ala Arg Ala Gly Ala Glu Glu Gly
            1060                1065                1070        
Gly Gln Gly Gln Ala Ala Gly Gly Gln Gln Val Ala Glu Gln Gly Pro
        1075                1080                1085            
Glu Pro Ala Glu Asp Gly Gly His Leu Ala Ser Glu Pro Glu Val Gln
    1090                1095                1100                
Pro Ser Asp Arg Ser Pro Leu Glu His Ser Ser Pro Glu Lys Glu Ala
1105                1110                1115                1120
Pro Ser Pro Glu Lys Thr Leu Pro Pro Gln Lys Thr Val Ala Ala Glu
                1125                1130                1135    
Ser His Glu Lys Val Pro Ser Ser Arg Glu Lys Arg Glu Ser Arg Arg
            1140                1145                1150        
Gln Arg Gly Leu Glu His Val Lys Phe Gln Asn Lys His Ile Gln Ser
        1155                1160                1165            
Cys Lys Glu Glu Ser Ala Leu Arg Glu Pro Ser Arg Arg Val Thr Gln
    1170                1175                1180                
Glu Gln Gly Val Ser Leu Leu Glu Asp Lys Lys Glu Ser Arg Glu Asp
1185                1190                1195                1200
Glu Thr Leu Leu Val Val Glu Thr Glu Ala Glu Asn Thr Ser Gln Lys
                1205                1210                1215    
Gln Pro Thr Glu Gln Pro Gln Ala Met Ala Val Gly Lys Val Ser Glu
            1220                1225                1230        
Glu Thr Glu Lys Thr Leu Pro Ser Gly Ser Pro Arg Pro Gly Gln Leu
        1235                1240                1245            
Glu Arg Pro Thr Ser Leu Ala Leu Asp Ser Arg Val Ser Pro Pro Ala
    1250                1255                1260                
Pro Gly Ser Ala Pro Glu Thr Pro Glu Asp Lys Ser Lys Pro Cys Gly
1265                1270                1275                1280
Ser Pro Arg Val Gln Glu Lys Pro Asp Ser Pro Gly Gly Ser Thr Gln
                1285                1290                1295    
Ile Gln Arg Tyr Leu Asp Ala Glu Arg Leu Ala Ser Ala Val Glu Leu
            1300                1305                1310        
Trp Arg Gly Lys Lys Leu Val Ala Ala Ala Ser Pro Ser Ala Met Leu
        1315                1320                1325            
Ser Gln Ser Leu Asp Leu Ser Asp Arg His Arg Ala Thr Gly Ala Ala
    1330                1335                1340                
Leu Thr Pro Thr Glu Glu Arg Arg Thr Ser Phe Ser Thr Ser Asp Val
1345                1350                1355                1360
Ser Lys Leu Leu Pro Ser Leu Ala Lys Ala Gln Pro Ala Ala Glu Thr
                1365                1370                1375    
Thr Asp Gly Glu Arg Ser Ala Lys Lys Pro Ala Val Gln Lys Lys Lys
            1380                1385                1390        
Pro Gly Asp Ala Ser Ser Leu Pro Asp Ala Gly Leu Ser Pro Gly Ser
        1395                1400                1405            
Gln Val Asp Ser Lys Ser Thr Phe Lys Arg Leu Phe Leu His Lys Thr
    1410                1415                1420                
Lys Asp Lys Lys Tyr Ser Leu Glu Gly Ala Glu Glu Leu Glu Asn Ala
1425                1430                1435                1440
Val Ser Gly His Val Val Leu Glu Ala Thr Thr Met Lys Lys Gly Leu
                1445                1450                1455    
Glu Ala Pro Ser Gly Gln Gln His Arg His Ala Ala Gly Glu Lys Arg
            1460                1465                1470        
Thr Lys Glu Pro Gly Gly Lys Gly Lys Lys Asn Arg Asn Val Lys Ile
        1475                1480                1485            
Gly Lys Ile Thr Val Ser Glu Lys Trp Arg Glu Ser Val Phe Arg Gln
    1490                1495                1500                
Ile Thr Asn Ala Asn Glu Leu Lys Tyr Leu Asp Glu Phe Leu Leu Asn
1505                1510                1515                1520
Lys Ile Asn Asp Leu Arg Ser Gln Lys Thr Pro Ile Glu Ser Leu Phe
                1525                1530                1535    
Ile Glu Ala Thr Glu Lys Phe Arg Ser Asn Ile Lys Thr Met Tyr Ser
            1540                1545                1550        
Val Pro Asn Gly Lys Ile His Val Gly Tyr Lys Asp Leu Met Glu Asn
        1555                1560                1565            
Tyr Gln Ile Val Val Ser Asn Leu Ala Thr Glu Arg Gly Gln Lys Asp
    1570                1575                1580                
Thr Asn Leu Val Leu Asn Leu Phe Gln Ser Leu Leu Asp Glu Phe Thr
1585                1590                1595                1600
Arg Gly Tyr Thr Lys Asn Asp Phe Glu Pro Val Lys Gln Ser Lys Ala
                1605                1610                1615    
Gln Lys Lys Lys Arg Lys Gln Glu Arg Ala Val Gln Glu His Asn Gly
            1620                1625                1630        
His Val Phe Ala Ser Tyr Gln Val Ser Ile Pro Gln Ser Cys Glu Gln
        1635                1640                1645            
Cys Leu Ser Tyr Ile Trp Leu Met Asp Lys Ala Leu Leu Cys Ser Val
    1650                1655                1660                
Cys Lys Met Thr Cys His Lys Lys Cys Val His Lys Ile Gln Ser His
1665                1670                1675                1680
Cys Ser Tyr Thr Tyr Gly Arg Lys Gly Glu Pro Gly Ala Glu Pro Gly
                1685                1690                1695    
His Phe Gly Val Cys Val Asp Ser Leu Thr Ser Asp Lys Ala Ser Val
            1700                1705                1710        
Pro Ile Val Leu Glu Lys Leu Leu Glu His Val Glu Met His Gly Leu
        1715                1720                1725            
Tyr Thr Glu Gly Leu Tyr Arg Lys Ser Gly Ala Ala Asn Arg Thr Arg
    1730                1735                1740                
Glu Leu Arg Gln Ala Leu Gln Thr Asp Pro Ala Ala Val Lys Leu Glu
1745                1750                1755                1760
Asn Phe Pro Ile His Ala Ile Thr Gly Val Leu Lys Gln Trp Leu Arg
                1765                1770                1775    
Glu Leu Pro Glu Pro Leu Met Thr Phe Ala Gln Tyr Gly Asp Phe Leu
            1780                1785                1790        
Arg Ala Val Glu Leu Pro Glu Lys Gln Glu Gln Leu Ala Ala Ile Tyr
        1795                1800                1805            
Ala Val Leu Glu His Leu Pro Glu Ala Asn His Asn Ser Leu Glu Arg
    1810                1815                1820                
Leu Ile Phe His Leu Val Lys Val Ala Leu Leu Glu Asp Val Asn Arg
1825                1830                1835                1840
Met Ser Pro Gly Ala Leu Ala Ile Ile Phe Ala Pro Cys Leu Leu Arg
                1845                1850                1855    
Cys Pro Asp Asn Ser Asp Pro Leu Thr Ser Met Lys Asp Val Leu Lys
            1860                1865                1870        
Ile Thr Thr Cys Val Glu Met Leu Ile Lys Glu Gln Met Arg Lys Tyr
        1875                1880                1885            
Lys Val Lys Met Glu Glu Ile Ser Gln Leu Glu Ala Ala Glu Ser Ile
    1890                1895                1900                
Ala Phe Arg Arg Leu Ser Leu Leu Arg Gln Asn Ala Asn Lys Ser Pro
1905                1910                1915                1920
Lys Thr Arg Glu Pro Ala Gly Gly Ala Gly Arg Leu Leu Thr Thr Ser
                1925                1930                1935    
Arg Val Ser Pro Ser Pro Ser Thr Arg Asn Leu Ala Leu Gly Ser Trp
            1940                1945                1950        
Arg Ser Ala Ala Leu Arg Thr Arg Gly Thr Gly Arg Pro Ala Arg Pro
        1955                1960                1965            
Gly Arg Ala Arg Ala Leu Arg Arg Arg Pro Pro Arg Pro Ala Arg Glu
    1970                1975                1980                
Ser Pro Ala Gln Pro Pro Arg Ser Arg Pro Arg Val Arg Thr Glu Thr
1985                1990                1995                2000
Pro Ser Pro Leu Ser Ser Gly Pro Pro Pro Ser Arg Ser Asn Thr Gly
                2005                2010                2015    
Met Ala Pro Leu Arg Arg
            2020        


<210> 599
<211> 355
<212> PRT
<213> Homo sapiens

<400> 599
Met Ala Leu Arg Leu Leu Lys Leu Ala Ala Thr Ser Ala Ser Ala Arg
 1               5                  10                  15      
Val Val Ala Ala Gly Ala Gln Arg Val Arg Gly Ile His Ser Ser Val
            20                  25                  30          
Gln Cys Lys Leu Arg Tyr Gly Met Trp His Phe Leu Leu Gly Asp Lys
        35                  40                  45              
Ala Ser Lys Arg Leu Thr Glu Arg Ser Arg Val Ile Thr Val Asp Gly
    50                  55                  60                  
Asn Ile Cys Thr Gly Lys Gly Lys Leu Ala Lys Glu Ile Ala Glu Lys
65                  70                  75                  80  
Leu Gly Phe Lys His Phe Pro Glu Ala Gly Ile His Tyr Pro Asp Ser
                85                  90                  95      
Thr Thr Gly Asp Gly Lys Pro Leu Ala Thr Asp Tyr Asn Gly Asn Cys
            100                 105                 110         
Ser Leu Glu Lys Phe Tyr Asp Asp Pro Arg Ser Asn Asp Gly Asn Ser
        115                 120                 125             
Tyr Arg Leu Gln Ser Trp Leu Tyr Ser Ser Arg Leu Leu Gln Tyr Ser
    130                 135                 140                 
Asp Ala Leu Glu His Leu Leu Thr Thr Gly Gln Gly Val Val Leu Glu
145                 150                 155                 160 
Arg Ser Ile Phe Ser Asp Phe Val Phe Leu Glu Ala Met Tyr Asn Gln
                165                 170                 175     
Gly Phe Ile Arg Lys Gln Cys Val Asp His Tyr Asn Glu Val Lys Ser
            180                 185                 190         
Val Thr Ile Cys Asp Tyr Leu Pro Pro His Leu Val Ile Tyr Ile Asp
        195                 200                 205             
Val Pro Val Pro Glu Val Gln Arg Arg Ile Gln Lys Lys Gly Asp Pro
    210                 215                 220                 
His Glu Met Lys Ile Thr Ser Ala Tyr Leu Gln Asp Ile Glu Asn Ala
225                 230                 235                 240 
Tyr Lys Lys Thr Phe Leu Pro Glu Met Ser Glu Lys Cys Glu Val Leu
                245                 250                 255     
Gln Tyr Ser Ala Arg Glu Ala Gln Asp Ser Lys Lys Val Val Glu Asp
            260                 265                 270         
Ile Glu Tyr Leu Lys Phe Asp Lys Gly Pro Trp Leu Lys Gln Asp Asn
        275                 280                 285             
Arg Thr Leu Tyr His Leu Arg Leu Leu Val Gln Asp Lys Phe Glu Val
    290                 295                 300                 
Leu Asn Tyr Thr Ser Ile Pro Ile Phe Leu Pro Glu Val Thr Ile Gly
305                 310                 315                 320 
Ala His Gln Thr Asp Arg Val Leu His Gln Phe Arg Glu Leu Pro Gly
                325                 330                 335     
Arg Lys Tyr Ser Pro Gly Tyr Asn Thr Glu Val Gly Asp Lys Trp Ile
            340                 345                 350         
Trp Leu Lys
        355 


<210> 600
<211> 84
<212> PRT
<213> Homo sapiens

<400> 600
Met Ala Ala Arg Val Gly Ala Phe Leu Lys Asn Ala Trp Asp Lys Glu
 1               5                  10                  15      
Pro Val Leu Val Val Ser Phe Val Val Gly Gly Leu Ala Val Ile Leu
            20                  25                  30          
Pro Pro Leu Ser Pro Tyr Phe Lys Tyr Ser Val Met Ile Asn Lys Ala
        35                  40                  45              
Thr Pro Tyr Asn Tyr Pro Val Pro Val Arg Asp Asp Gly Asn Met Pro
    50                  55                  60                  
Asp Val Pro Ser His Pro Gln Asp Pro Gln Gly Pro Ser Leu Glu Trp
65                  70                  75                  80  
Leu Lys Lys Leu
                


<210> 601
<211> 172
<212> PRT
<213> Homo sapiens

<400> 601
Met Pro Asp Ser Trp Asp Lys Asp Val Tyr Pro Glu Pro Pro Arg Arg
 1               5                  10                  15      
Thr Pro Val Gln Pro Asn Pro Ile Val Tyr Met Met Lys Ala Phe Asp
            20                  25                  30          
Leu Ile Val Asp Arg Pro Val Thr Leu Val Arg Glu Phe Ile Glu Arg
        35                  40                  45              
Gln His Ala Lys Asn Arg Tyr Tyr Tyr Tyr His Arg Gln Tyr Arg Arg
    50                  55                  60                  
Val Pro Asp Ile Thr Glu Cys Lys Glu Glu Asp Ile Met Cys Met Tyr
65                  70                  75                  80  
Glu Ala Glu Met Gln Trp Lys Arg Asp Tyr Lys Val Asp Gln Glu Ile
                85                  90                  95      
Ile Asn Ile Met Gln Asp Arg Leu Lys Ala Cys Gln Gln Arg Glu Gly
            100                 105                 110         
Gln Asn Tyr Gln Gln Asn Cys Ile Lys Glu Val Glu Gln Phe Thr Gln
        115                 120                 125             
Val Ala Lys Ala Tyr Gln Asp Arg Tyr Gln Asp Leu Gly Ala Tyr Ser
    130                 135                 140                 
Ser Ala Arg Lys Cys Leu Ala Lys Gln Arg Gln Arg Met Leu Gln Glu
145                 150                 155                 160 
Arg Lys Ala Ala Lys Glu Ala Ala Ala Ala Thr Ser
                165                 170         


<210> 602
<211> 58
<212> PRT
<213> Homo sapiens

<400> 602
Met Val Asn Leu Leu Gln Ile Val Arg Asp His Trp Val His Val Leu
 1               5                  10                  15      
Val Pro Met Gly Phe Val Ile Gly Cys Tyr Leu Asp Arg Lys Ser Asp
            20                  25                  30          
Glu Arg Leu Thr Ala Phe Arg Asn Lys Ser Met Leu Phe Lys Arg Glu
        35                  40                  45              
Leu Gln Pro Ser Glu Glu Val Thr Trp Lys
    50                  55              


<210> 603
<211> 105
<212> PRT
<213> Homo sapiens

<400> 603
Met Ser Ala Leu Thr Arg Leu Ala Ser Phe Ala Arg Val Gly Gly Arg
 1               5                  10                  15      
Leu Phe Arg Ser Gly Cys Ala Arg Thr Ala Gly Asp Gly Gly Val Arg
            20                  25                  30          
His Ala Gly Gly Gly Val His Ile Glu Pro Arg Tyr Arg Gln Phe Pro
        35                  40                  45              
Gln Leu Thr Arg Ser Gln Val Phe Gln Ser Glu Phe Phe Ser Gly Leu
    50                  55                  60                  
Met Trp Phe Trp Ile Leu Trp Arg Phe Trp His Asp Ser Glu Glu Val
65                  70                  75                  80  
Leu Gly His Phe Pro Tyr Pro Asp Pro Ser Gln Trp Thr Asp Glu Glu
                85                  90                  95      
Leu Gly Ile Pro Pro Asp Asp Glu Asp
            100                 105 


<210> 604
<211> 119
<212> PRT
<213> Homo sapiens

<400> 604
Met Ile Ala Arg Arg Asn Pro Glu Pro Leu Arg Phe Leu Pro Asp Glu
 1               5                  10                  15      
Ala Arg Ser Leu Pro Pro Pro Lys Leu Thr Asp Pro Arg Leu Leu Tyr
            20                  25                  30          
Ile Gly Phe Leu Gly Tyr Cys Ser Gly Leu Ile Asp Asn Leu Ile Arg
        35                  40                  45              
Arg Arg Pro Ile Ala Thr Ala Gly Leu His Arg Gln Leu Leu Tyr Ile
    50                  55                  60                  
Thr Ala Phe Phe Phe Ala Gly Tyr Tyr Leu Val Lys Arg Glu Asp Tyr
65                  70                  75                  80  
Leu Tyr Ala Val Arg Asp Arg Glu Met Phe Gly Tyr Met Lys Leu His
                85                  90                  95      
Pro Glu Asp Phe Pro Glu Glu Asp Lys Lys Thr Tyr Gly Glu Ile Phe
            100                 105                 110         
Glu Lys Phe His Pro Ile Arg
        115                 


<210> 605
<211> 463
<212> PRT
<213> Homo sapiens

<400> 605
Met Ala Ala Leu Arg Ala Leu Cys Gly Phe Arg Gly Val Ala Ala Gln
 1               5                  10                  15      
Val Leu Arg Pro Gly Ala Gly Val Arg Leu Pro Ile Gln Pro Ser Arg
            20                  25                  30          
Gly Val Arg Gln Trp Gln Pro Asp Val Glu Trp Ala Gln Gln Phe Gly
        35                  40                  45              
Gly Ala Val Met Tyr Pro Ser Lys Glu Thr Ala His Trp Lys Pro Pro
    50                  55                  60                  
Pro Trp Asn Asp Val Asp Pro Pro Lys Asp Thr Ile Val Lys Asn Ile
65                  70                  75                  80  
Thr Leu Asn Phe Gly Pro Gln His Pro Ala Ala His Gly Val Leu Arg
                85                  90                  95      
Leu Val Met Glu Leu Ser Gly Glu Met Val Arg Lys Cys Asp Pro His
            100                 105                 110         
Ile Gly Leu Leu His Arg Gly Thr Glu Lys Leu Ile Glu Tyr Lys Thr
        115                 120                 125             
Tyr Leu Gln Ala Leu Pro Tyr Phe Asp Arg Leu Asp Tyr Val Ser Met
    130                 135                 140                 
Met Cys Asn Glu Gln Ala Tyr Ser Leu Ala Val Glu Lys Leu Leu Asn
145                 150                 155                 160 
Ile Arg Pro Pro Pro Arg Ala Gln Trp Ile Arg Val Leu Phe Gly Glu
                165                 170                 175     
Ile Thr Arg Leu Leu Asn His Ile Met Ala Val Thr Thr His Ala Leu
            180                 185                 190         
Asp Leu Gly Ala Met Thr Pro Phe Phe Trp Leu Phe Glu Glu Arg Glu
        195                 200                 205             
Lys Met Phe Glu Phe Tyr Glu Arg Val Ser Gly Ala Arg Met His Ala
    210                 215                 220                 
Ala Tyr Ile Arg Pro Gly Gly Val His Gln Asp Leu Pro Leu Gly Leu
225                 230                 235                 240 
Met Asp Asp Ile Tyr Gln Phe Ser Lys Asn Phe Ser Leu Arg Leu Asp
                245                 250                 255     
Glu Leu Glu Glu Leu Leu Thr Asn Asn Arg Ile Trp Arg Asn Arg Thr
            260                 265                 270         
Ile Asp Ile Gly Val Val Thr Ala Glu Glu Ala Leu Asn Tyr Gly Phe
        275                 280                 285             
Ser Gly Val Met Leu Arg Gly Ser Gly Ile Gln Trp Asp Leu Arg Lys
    290                 295                 300                 
Thr Gln Pro Tyr Asp Val Tyr Asp Gln Val Glu Phe Asp Val Pro Val
305                 310                 315                 320 
Gly Ser Arg Gly Asp Cys Tyr Asp Arg Tyr Leu Cys Arg Val Glu Glu
                325                 330                 335     
Met Arg Gln Ser Leu Arg Ile Ile Ala Gln Cys Leu Asn Lys Met Pro
            340                 345                 350         
Pro Gly Glu Ile Lys Val Asp Asp Ala Lys Val Ser Pro Pro Lys Arg
        355                 360                 365             
Ala Glu Met Lys Thr Ser Met Glu Ser Leu Ile His His Phe Lys Leu
    370                 375                 380                 
Tyr Thr Glu Gly Tyr Gln Val Pro Pro Gly Ala Thr Tyr Thr Ala Ile
385                 390                 395                 400 
Glu Ala Pro Lys Gly Glu Phe Gly Val Tyr Leu Val Ser Asp Gly Ser
                405                 410                 415     
Ser Arg Pro Tyr Arg Cys Lys Ile Lys Ala Pro Gly Phe Ala His Leu
            420                 425                 430         
Ala Gly Leu Asp Lys Met Ser Lys Gly His Met Leu Ala Asp Val Val
        435                 440                 445             
Ala Ile Ile Gly Thr Gln Asp Ile Val Phe Gly Glu Val Asp Arg
    450                 455                 460             


<210> 606
<211> 264
<212> PRT
<213> Homo sapiens

<400> 606
Met Ala Ala Ala Ala Val Ala Arg Leu Trp Trp Arg Gly Ile Leu Gly
 1               5                  10                  15      
Ala Ser Ala Leu Thr Arg Gly Thr Gly Arg Pro Ser Val Leu Leu Leu
            20                  25                  30          
Pro Val Arg Arg Glu Ser Ala Gly Ala Asp Thr Arg Pro Thr Val Arg
        35                  40                  45              
Pro Arg Asn Asp Val Ala His Lys Gln Leu Ser Ala Phe Gly Glu Tyr
    50                  55                  60                  
Val Ala Glu Ile Leu Pro Lys Tyr Val Gln Gln Val Gln Val Ser Cys
65                  70                  75                  80  
Phe Asn Glu Leu Glu Val Cys Ile His Pro Asp Gly Val Ile Pro Val
                85                  90                  95      
Leu Thr Phe Leu Arg Asp His Thr Asn Ala Gln Phe Lys Ser Leu Val
            100                 105                 110         
Asp Leu Thr Ala Val Asp Val Pro Thr Arg Gln Asn Arg Phe Glu Ile
        115                 120                 125             
Val Tyr Asn Leu Leu Ser Leu Arg Phe Asn Ser Arg Ile Arg Val Lys
    130                 135                 140                 
Thr Tyr Thr Asp Glu Leu Thr Pro Ile Glu Ser Ala Val Ser Val Phe
145                 150                 155                 160 
Lys Ala Ala Asn Trp Tyr Glu Arg Glu Ile Trp Asp Met Phe Gly Val
                165                 170                 175     
Phe Phe Ala Asn His Pro Asp Leu Arg Arg Ile Leu Thr Asp Tyr Gly
            180                 185                 190         
Phe Glu Gly His Pro Phe Arg Lys Asp Phe Pro Leu Ser Gly Tyr Val
        195                 200                 205             
Glu Leu Arg Tyr Asp Asp Glu Val Lys Arg Val Val Ala Glu Pro Val
    210                 215                 220                 
Glu Leu Ala Gln Glu Phe Arg Lys Phe Asp Leu Asn Ser Pro Trp Glu
225                 230                 235                 240 
Ala Phe Pro Val Tyr Arg Gln Pro Pro Glu Ser Leu Lys Leu Glu Ala
                245                 250                 255     
Gly Asp Lys Lys Pro Asp Ala Lys
            260                 


<210> 607
<211> 106
<212> PRT
<213> Homo sapiens

<400> 607
Met Pro Phe Leu Asp Ile Gln Lys Arg Phe Gly Leu Asn Ile Asp Arg
 1               5                  10                  15      
Trp Leu Thr Ile Gln Ser Gly Glu Gln Pro Tyr Lys Met Ala Gly Arg
            20                  25                  30          
Cys His Ala Phe Glu Lys Glu Trp Ile Glu Cys Ala His Gly Ile Gly
        35                  40                  45              
Tyr Thr Arg Ala Glu Lys Glu Cys Lys Ile Glu Tyr Asp Asp Phe Val
    50                  55                  60                  
Glu Cys Leu Leu Arg Gln Lys Thr Met Arg Arg Ala Gly Thr Ile Arg
65                  70                  75                  80  
Lys Gln Arg Asp Lys Leu Ile Lys Glu Gly Lys Tyr Thr Pro Pro Pro
                85                  90                  95      
His His Ile Gly Lys Gly Glu Pro Arg Pro
            100                 105     


<210> 608
<211> 124
<212> PRT
<213> Homo sapiens

<400> 608
Met Ala Ala Ala Met Thr Phe Cys Arg Leu Leu Asn Arg Cys Gly Glu
 1               5                  10                  15      
Ala Ala Arg Ser Leu Pro Leu Gly Ala Arg Cys Phe Gly Val Arg Val
            20                  25                  30          
Ser Pro Thr Gly Glu Lys Val Thr His Thr Gly Gln Val Tyr Asp Asp
        35                  40                  45              
Lys Asp Tyr Arg Arg Ile Arg Phe Val Gly Arg Gln Lys Glu Val Asn
    50                  55                  60                  
Glu Asn Phe Ala Ile Asp Leu Ile Ala Glu Gln Pro Val Ser Glu Val
65                  70                  75                  80  
Glu Thr Arg Val Ile Ala Cys Asp Gly Gly Gly Gly Ala Leu Gly His
                85                  90                  95      
Pro Lys Val Tyr Ile Asn Leu Asp Lys Glu Thr Lys Thr Gly Thr Cys
            100                 105                 110         
Gly Tyr Cys Gly Leu Gln Phe Arg Gln His His His
        115                 120                 


<210> 609
<211> 2003
<212> PRT
<213> Homo sapiens

<400> 609
Met Gln Pro Pro Ser Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu
 1               5                  10                  15      
Cys Val Ser Val Val Arg Pro Arg Gly Leu Leu Cys Gly Ser Phe Pro
            20                  25                  30          
Glu Pro Cys Ala Asn Gly Gly Thr Cys Leu Ser Leu Ser Leu Gly Gln
        35                  40                  45              
Gly Thr Cys Gln Cys Ala Pro Gly Phe Leu Gly Glu Thr Cys Gln Phe
    50                  55                  60                  
Pro Asp Pro Cys Gln Asn Ala Gln Leu Cys Gln Asn Gly Gly Ser Cys
65                  70                  75                  80  
Gln Ala Leu Leu Pro Ala Pro Leu Gly Leu Pro Ser Ser Pro Ser Pro
                85                  90                  95      
Leu Thr Pro Ser Phe Leu Cys Thr Cys Leu Pro Gly Phe Thr Gly Glu
            100                 105                 110         
Arg Cys Gln Ala Lys Leu Glu Asp Pro Cys Pro Pro Ser Phe Cys Ser
        115                 120                 125             
Lys Arg Gly Arg Cys His Ile Gln Ala Ser Gly Arg Pro Gln Cys Ser
    130                 135                 140                 
Cys Met Pro Gly Trp Thr Gly Glu Gln Cys Gln Leu Arg Asp Phe Cys
145                 150                 155                 160 
Ser Ala Asn Pro Cys Val Asn Gly Gly Val Cys Leu Ala Thr Tyr Pro
                165                 170                 175     
Gln Ile Gln Cys His Cys Pro Pro Gly Phe Glu Gly His Ala Cys Glu
            180                 185                 190         
Arg Asp Val Asn Glu Cys Phe Gln Asp Pro Gly Pro Cys Pro Lys Gly
        195                 200                 205             
Thr Ser Cys His Asn Thr Leu Gly Ser Phe Gln Cys Leu Cys Pro Val
    210                 215                 220                 
Gly Gln Glu Gly Pro Arg Cys Glu Leu Arg Ala Gly Pro Cys Pro Pro
225                 230                 235                 240 
Arg Gly Cys Ser Asn Gly Gly Thr Cys Gln Leu Met Pro Glu Lys Asp
                245                 250                 255     
Ser Thr Phe His Leu Cys Leu Cys Pro Pro Gly Phe Ile Gly Pro Asp
            260                 265                 270         
Cys Glu Val Asn Pro Asp Asn Cys Val Ser His Gln Cys Gln Asn Gly
        275                 280                 285             
Gly Thr Cys Gln Asp Gly Leu Asp Thr Tyr Thr Cys Leu Cys Pro Glu
    290                 295                 300                 
Thr Trp Thr Gly Trp Asp Cys Ser Glu Asp Val Asp Glu Cys Glu Thr
305                 310                 315                 320 
Gln Gly Pro Pro His Cys Arg Asn Gly Gly Thr Cys Gln Asn Ser Ala
                325                 330                 335     
Gly Ser Phe His Cys Val Cys Val Ser Gly Trp Gly Gly Thr Ser Cys
            340                 345                 350         
Glu Glu Asn Leu Asp Asp Cys Ile Ala Ala Thr Cys Ala Pro Gly Ser
        355                 360                 365             
Thr Cys Ile Asp Arg Val Gly Ser Phe Ser Cys Leu Cys Pro Pro Gly
    370                 375                 380                 
Arg Thr Gly Leu Leu Cys His Leu Glu Asp Met Cys Leu Ser Gln Pro
385                 390                 395                 400 
Cys His Gly Asp Ala Gln Cys Ser Thr Asn Pro Leu Thr Gly Ser Thr
                405                 410                 415     
Leu Cys Leu Cys Gln Pro Gly Tyr Ser Gly Pro Thr Cys His Gln Asp
            420                 425                 430         
Leu Asp Glu Cys Leu Met Ala Gln Gln Gly Pro Ser Pro Cys Glu His
        435                 440                 445             
Gly Gly Ser Cys Leu Asn Thr Pro Gly Ser Phe Asn Cys Leu Cys Pro
    450                 455                 460                 
Pro Gly Tyr Thr Gly Ser Arg Cys Glu Ala Asp His Asn Glu Cys Leu
465                 470                 475                 480 
Ser Gln Pro Cys His Pro Gly Ser Thr Cys Leu Asp Leu Leu Ala Thr
                485                 490                 495     
Phe His Cys Leu Cys Pro Pro Gly Leu Glu Gly Gln Leu Cys Glu Val
            500                 505                 510         
Glu Thr Asn Glu Cys Ala Ser Ala Pro Cys Leu Asn His Ala Asp Cys
        515                 520                 525             
His Asp Leu Leu Asn Gly Phe Gln Cys Ile Cys Leu Pro Gly Phe Ser
    530                 535                 540                 
Gly Thr Arg Cys Glu Glu Asp Ile Asp Glu Cys Arg Ser Ser Pro Cys
545                 550                 555                 560 
Ala Asn Gly Gly Gln Cys Gln Asp Gln Pro Gly Ala Phe His Cys Lys
                565                 570                 575     
Cys Leu Pro Gly Phe Glu Gly Pro Arg Cys Gln Thr Glu Val Asp Glu
            580                 585                 590         
Cys Leu Ser Asp Pro Cys Pro Val Gly Ala Ser Cys Leu Asp Leu Pro
        595                 600                 605             
Gly Ala Phe Phe Cys Leu Cys Pro Ser Gly Phe Thr Gly Gln Leu Cys
    610                 615                 620                 
Glu Val Pro Leu Cys Ala Pro Asn Leu Cys Gln Pro Lys Gln Ile Cys
625                 630                 635                 640 
Lys Asp Gln Lys Asp Lys Ala Asn Cys Leu Cys Pro Asp Gly Ser Pro
                645                 650                 655     
Gly Cys Ala Pro Pro Glu Asp Asn Cys Thr Cys His His Gly His Cys
            660                 665                 670         
Gln Arg Ser Ser Cys Val Cys Asp Val Gly Trp Thr Gly Pro Glu Cys
        675                 680                 685             
Glu Ala Glu Leu Gly Gly Cys Ile Ser Ala Pro Cys Ala His Gly Gly
    690                 695                 700                 
Thr Cys Tyr Pro Gln Pro Ser Gly Tyr Asn Cys Thr Cys Pro Thr Gly
705                 710                 715                 720 
Tyr Thr Gly Pro Thr Cys Ser Glu Glu Met Thr Ala Cys His Ser Gly
                725                 730                 735     
Pro Cys Leu Asn Gly Gly Ser Cys Asn Pro Ser Pro Gly Gly Tyr Tyr
            740                 745                 750         
Cys Thr Cys Pro Pro Ser His Thr Gly Pro Gln Cys Gln Thr Ser Thr
        755                 760                 765             
Asp Tyr Cys Val Ser Ala Pro Cys Phe Asn Gly Gly Thr Cys Val Asn
    770                 775                 780                 
Arg Pro Gly Thr Phe Ser Cys Leu Cys Ala Met Gly Phe Gln Gly Pro
785                 790                 795                 800 
Arg Cys Glu Gly Lys Leu Arg Pro Ser Cys Ala Asp Ser Pro Cys Arg
                805                 810                 815     
Asn Arg Ala Thr Cys Gln Asp Ser Pro Gln Gly Pro Arg Cys Leu Cys
            820                 825                 830         
Pro Thr Gly Tyr Thr Gly Gly Ser Cys Gln Thr Leu Met Asp Leu Cys
        835                 840                 845             
Ala Gln Lys Pro Cys Pro Arg Asn Ser His Cys Leu Gln Thr Gly Pro
    850                 855                 860                 
Ser Phe His Cys Leu Cys Leu Gln Gly Trp Thr Gly Pro Leu Cys Asn
865                 870                 875                 880 
Leu Pro Leu Ser Ser Cys Gln Lys Ala Ala Leu Ser Gln Gly Ile Asp
                885                 890                 895     
Val Ser Ser Leu Cys His Asn Gly Gly Leu Cys Val Asp Ser Gly Pro
            900                 905                 910         
Ser Tyr Phe Cys His Cys Pro Pro Gly Phe Gln Gly Ser Leu Cys Gln
        915                 920                 925             
Asp His Val Asn Pro Cys Glu Ser Arg Pro Cys Gln Asn Gly Ala Thr
    930                 935                 940                 
Cys Met Ala Gln Pro Ser Gly Tyr Leu Cys Gln Cys Ala Pro Gly Tyr
945                 950                 955                 960 
Asp Gly Gln Asn Cys Ser Lys Glu Leu Asp Ala Cys Gln Ser Gln Pro
                965                 970                 975     
Cys His Asn His Gly Thr Cys Thr Pro Lys Pro Gly Gly Phe His Cys
            980                 985                 990         
Ala Cys Pro Pro Gly Phe Val Gly Leu Arg Cys Glu Gly Asp Val Asp
        995                 1000                1005            
Glu Cys Leu Asp Gln Pro Cys His Pro Thr Gly Thr Ala Ala Cys His
    1010                1015                1020                
Ser Leu Ala Asn Ala Phe Tyr Cys Gln Cys Leu Pro Gly His Thr Gly
1025                1030                1035                1040
Gln Trp Cys Glu Val Glu Ile Asp Pro Cys His Ser Gln Pro Cys Phe
                1045                1050                1055    
His Gly Gly Thr Cys Glu Ala Thr Ala Gly Ser Pro Leu Gly Phe Ile
            1060                1065                1070        
Cys His Cys Pro Lys Gly Phe Glu Gly Pro Thr Cys Ser His Arg Ala
        1075                1080                1085            
Pro Ser Cys Gly Phe His His Cys His His Gly Gly Leu Cys Leu Pro
    1090                1095                1100                
Ser Pro Lys Pro Gly Phe Pro Pro Arg Cys Ala Cys Leu Ser Gly Tyr
1105                1110                1115                1120
Gly Gly Pro Asp Cys Leu Thr Pro Pro Ala Pro Lys Gly Cys Gly Pro
                1125                1130                1135    
Pro Ser Pro Cys Leu Tyr Asn Gly Ser Cys Ser Glu Thr Thr Gly Leu
            1140                1145                1150        
Gly Gly Pro Gly Phe Arg Cys Ser Cys Pro His Ser Ser Pro Gly Pro
        1155                1160                1165            
Arg Cys Gln Lys Pro Gly Ala Lys Gly Cys Glu Gly Arg Ser Gly Asp
    1170                1175                1180                
Gly Ala Cys Asp Ala Gly Cys Ser Gly Pro Gly Gly Asn Trp Asp Gly
1185                1190                1195                1200
Gly Asp Cys Ser Leu Gly Val Pro Asp Pro Trp Lys Gly Cys Pro Ser
                1205                1210                1215    
His Ser Arg Cys Trp Leu Leu Phe Arg Asp Gly Gln Cys His Pro Gln
            1220                1225                1230        
Cys Asp Ser Glu Glu Cys Leu Phe Asp Gly Tyr Asp Cys Glu Thr Pro
        1235                1240                1245            
Pro Ala Cys Thr Pro Ala Tyr Asp Gln Tyr Cys His Asp His Phe His
    1250                1255                1260                
Asn Gly His Cys Glu Lys Gly Cys Asn Thr Ala Glu Cys Gly Trp Asp
1265                1270                1275                1280
Gly Gly Asp Cys Arg Pro Glu Asp Gly Asp Pro Glu Trp Gly Pro Ser
                1285                1290                1295    
Leu Ala Leu Leu Val Val Leu Ser Pro Pro Ala Leu Asp Gln Gln Leu
            1300                1305                1310        
Phe Ala Leu Ala Arg Val Leu Ser Leu Thr Leu Arg Val Gly Leu Trp
        1315                1320                1325            
Val Arg Lys Asp Arg Asp Gly Arg Asp Met Val Tyr Pro Tyr Pro Gly
    1330                1335                1340                
Ala Arg Ala Glu Glu Lys Leu Gly Gly Thr Arg Asp Pro Thr Tyr Gln
1345                1350                1355                1360
Glu Arg Ala Ala Pro Gln Thr Gln Pro Leu Gly Lys Glu Thr Asp Ser
                1365                1370                1375    
Leu Ser Ala Gly Phe Val Val Val Met Gly Val Asp Leu Ser Arg Cys
            1380                1385                1390        
Gly Pro Asp His Pro Ala Ser Arg Cys Pro Trp Asp Pro Gly Leu Leu
        1395                1400                1405            
Leu Arg Phe Leu Ala Ala Met Ala Ala Val Gly Ala Leu Glu Pro Leu
    1410                1415                1420                
Leu Pro Gly Pro Leu Leu Ala Val His Pro His Ala Gly Thr Ala Pro
1425                1430                1435                1440
Pro Ala Asn Gln Leu Pro Trp Pro Val Leu Cys Ser Pro Val Ala Gly
                1445                1450                1455    
Val Ile Leu Leu Ala Leu Gly Ala Leu Leu Val Leu Gln Leu Ile Arg
            1460                1465                1470        
Arg Arg Arg Arg Glu His Gly Ala Leu Trp Leu Pro Pro Gly Phe Thr
        1475                1480                1485            
Arg Arg Pro Arg Thr Gln Ser Ala Pro His Arg Arg Arg Pro Pro Leu
    1490                1495                1500                
Gly Glu Asp Ser Ile Gly Leu Lys Ala Leu Lys Pro Lys Ala Glu Val
1505                1510                1515                1520
Asp Glu Asp Gly Val Val Met Cys Ser Gly Pro Glu Glu Gly Glu Glu
                1525                1530                1535    
Val Gly Gln Ala Glu Glu Thr Gly Pro Pro Ser Thr Cys Gln Leu Trp
            1540                1545                1550        
Ser Leu Ser Gly Gly Cys Gly Ala Leu Pro Gln Ala Ala Met Leu Thr
        1555                1560                1565            
Pro Pro Gln Glu Ser Glu Met Glu Ala Pro Asp Leu Asp Thr Arg Gly
    1570                1575                1580                
Pro Asp Gly Val Thr Pro Leu Met Ser Ala Val Cys Cys Gly Glu Val
1585                1590                1595                1600
Gln Ser Gly Thr Phe Gln Gly Ala Trp Leu Gly Cys Pro Glu Pro Trp
                1605                1610                1615    
Glu Pro Leu Leu Asp Gly Gly Ala Cys Pro Gln Ala His Thr Val Gly
            1620                1625                1630        
Thr Gly Glu Thr Pro Leu His Leu Ala Ala Arg Phe Ser Arg Pro Thr
        1635                1640                1645            
Ala Ala Arg Arg Leu Leu Glu Ala Gly Ala Asn Pro Asn Gln Pro Asp
    1650                1655                1660                
Arg Ala Gly Arg Thr Pro Leu His Ala Ala Val Ala Ala Asp Ala Arg
1665                1670                1675                1680
Glu Val Cys Gln Leu Leu Leu Arg Ser Arg Gln Thr Ala Val Asp Ala
                1685                1690                1695    
Arg Thr Glu Asp Gly Thr Thr Pro Leu Met Leu Ala Ala Arg Leu Ala
            1700                1705                1710        
Val Glu Asp Leu Val Glu Glu Leu Ile Ala Ala Gln Ala Asp Val Gly
        1715                1720                1725            
Ala Arg Asp Lys Trp Gly Lys Thr Ala Leu His Trp Ala Ala Ala Val
    1730                1735                1740                
Asn Asn Ala Arg Ala Ala Arg Ser Leu Leu Gln Ala Gly Ala Asp Lys
1745                1750                1755                1760
Asp Ala Gln Asp Asn Arg Glu Gln Thr Pro Leu Phe Leu Ala Ala Arg
                1765                1770                1775    
Glu Gly Ala Val Glu Val Ala Gln Leu Leu Leu Gly Leu Gly Ala Ala
            1780                1785                1790        
Arg Glu Leu Arg Asp Gln Ala Gly Leu Ala Pro Ala Asp Val Ala His
        1795                1800                1805            
Gln Arg Asn His Trp Asp Leu Leu Thr Leu Leu Glu Gly Ala Gly Pro
    1810                1815                1820                
Pro Glu Ala Arg His Lys Ala Thr Pro Gly Arg Glu Ala Gly Pro Phe
1825                1830                1835                1840
Pro Arg Ala Arg Thr Val Ser Val Ser Val Pro Pro His Gly Gly Gly
                1845                1850                1855    
Ala Leu Pro Arg Cys Arg Thr Leu Ser Ala Gly Ala Gly Pro Arg Gly
            1860                1865                1870        
Gly Gly Ala Cys Leu Gln Ala Arg Thr Trp Ser Val Asp Leu Ala Ala
        1875                1880                1885            
Arg Gly Gly Gly Ala Tyr Ser His Cys Arg Ser Leu Ser Gly Val Gly
    1890                1895                1900                
Ala Gly Gly Gly Pro Thr Pro Arg Gly Arg Arg Phe Ser Ala Gly Met
1905                1910                1915                1920
Arg Gly Pro Arg Pro Asn Pro Ala Ile Met Arg Gly Arg Tyr Gly Val
                1925                1930                1935    
Ala Ala Gly Arg Gly Gly Arg Val Ser Thr Asp Asp Trp Pro Cys Asp
            1940                1945                1950        
Trp Val Ala Leu Gly Ala Cys Gly Ser Ala Ser Asn Ile Pro Ile Pro
        1955                1960                1965            
Pro Pro Cys Leu Thr Pro Ser Pro Glu Arg Gly Ser Pro Gln Leu Asp
    1970                1975                1980                
Cys Gly Pro Pro Ala Leu Gln Glu Met Pro Ile Asn Gln Gly Gly Glu
1985                1990                1995                2000
Gly Lys Lys
            


<210> 610
<211> 850
<212> PRT
<213> Homo sapiens

<400> 610
Met Arg Gln Val Cys Cys Ser Ala Leu Pro Pro Pro Pro Leu Glu Lys
 1               5                  10                  15      
Gly Arg Cys Ser Ser Tyr Ser Asp Ser Ser Ser Ser Ser Ser Glu Arg
            20                  25                  30          
Ser Ser Ser Ser Ser Ser Ser Ser Ser Glu Ser Gly Ser Ser Ser Arg
        35                  40                  45              
Ser Ser Ser Asn Asn Ser Ser Ile Ser Arg Pro Ala Ala Pro Pro Glu
    50                  55                  60                  
Pro Arg Pro Gln Gln Gln Pro Gln Pro Arg Ser Pro Ala Ala Arg Arg
65                  70                  75                  80  
Ala Ala Ala Arg Ser Arg Ala Ala Ala Ala Gly Gly Met Arg Arg Asp
                85                  90                  95      
Pro Ala Pro Gly Phe Ser Met Leu Leu Phe Gly Val Ser Leu Ala Cys
            100                 105                 110         
Tyr Ser Pro Ser Leu Lys Ser Val Gln Asp Gln Ala Tyr Lys Ala Pro
        115                 120                 125             
Val Val Val Glu Gly Lys Val Gln Gly Leu Val Pro Ala Gly Gly Ser
    130                 135                 140                 
Ser Ser Asn Ser Thr Arg Glu Pro Pro Ala Ser Gly Arg Val Ala Leu
145                 150                 155                 160 
Val Lys Val Leu Asp Lys Trp Pro Leu Arg Ser Gly Gly Leu Gln Arg
                165                 170                 175     
Glu Gln Val Ile Ser Val Gly Ser Cys Val Pro Leu Glu Arg Asn Gln
            180                 185                 190         
Arg Tyr Ile Phe Phe Leu Glu Pro Thr Glu Gln Pro Leu Val Phe Lys
        195                 200                 205             
Thr Ala Phe Ala Pro Leu Asp Thr Asn Gly Lys Asn Leu Lys Lys Glu
    210                 215                 220                 
Val Gly Lys Ile Leu Cys Thr Asp Cys Ala Thr Arg Pro Lys Leu Lys
225                 230                 235                 240 
Lys Met Lys Ser Gln Thr Gly Gln Val Gly Glu Lys Gln Ser Leu Lys
                245                 250                 255     
Cys Glu Ala Ala Ala Gly Asn Pro Gln Pro Ser Tyr Arg Trp Phe Lys
            260                 265                 270         
Asp Gly Lys Glu Leu Asn Arg Ser Arg Asp Ile Arg Ile Lys Tyr Gly
        275                 280                 285             
Asn Gly Arg Lys Asn Ser Arg Leu Gln Phe Asn Lys Val Lys Val Glu
    290                 295                 300                 
Asp Ala Gly Glu Tyr Val Cys Glu Ala Glu Asn Ile Leu Gly Lys Asp
305                 310                 315                 320 
Thr Val Arg Gly Arg Leu Tyr Val Asn Ser Val Ser Thr Thr Leu Ser
                325                 330                 335     
Ser Trp Ser Gly His Ala Arg Lys Cys Asn Glu Thr Ala Lys Ser Tyr
            340                 345                 350         
Cys Val Asn Gly Gly Val Cys Tyr Tyr Ile Glu Gly Ile Asn Gln Leu
        355                 360                 365             
Ser Cys Lys Cys Pro Asn Gly Phe Phe Gly Gln Arg Cys Leu Glu Lys
    370                 375                 380                 
Leu Pro Leu Arg Leu Tyr Met Pro Asp Pro Lys Gln Lys Ala Glu Glu
385                 390                 395                 400 
Leu Tyr Gln Lys Arg Val Leu Thr Ile Thr Gly Ile Cys Val Ala Leu
                405                 410                 415     
Leu Val Val Gly Ile Val Cys Val Val Ala Tyr Cys Lys Thr Lys Lys
            420                 425                 430         
Gln Arg Lys Gln Met His Asn His Leu Arg Gln Asn Met Cys Pro Ala
        435                 440                 445             
His Gln Asn Arg Ser Leu Ala Asn Gly Pro Ser His Pro Arg Leu Asp
    450                 455                 460                 
Pro Glu Glu Ile Gln Met Ala Asp Tyr Ile Ser Lys Asn Val Pro Ala
465                 470                 475                 480 
Thr Asp His Val Ile Arg Arg Glu Thr Glu Thr Thr Phe Ser Gly Ser
                485                 490                 495     
His Ser Cys Ser Pro Ser His His Cys Ser Thr Ala Thr Pro Thr Ser
            500                 505                 510         
Ser His Arg His Glu Ser His Thr Trp Ser Leu Glu Arg Ser Glu Ser
        515                 520                 525             
Leu Thr Ser Asp Ser Gln Ser Gly Ile Met Leu Ser Ser Val Gly Thr
    530                 535                 540                 
Ser Lys Cys Asn Ser Pro Ala Cys Val Glu Ala Arg Ala Arg Arg Ala
545                 550                 555                 560 
Ala Ala Tyr Asn Leu Glu Glu Arg Arg Arg Ala Thr Ala Pro Pro Tyr
                565                 570                 575     
His Asp Ser Val Asp Ser Leu Arg Asp Ser Pro His Ser Glu Arg Tyr
            580                 585                 590         
Val Ser Ala Leu Thr Thr Pro Ala Arg Leu Ser Pro Val Asp Phe His
        595                 600                 605             
Tyr Ser Leu Ala Thr Gln Val Pro Thr Phe Glu Ile Thr Ser Pro Asn
    610                 615                 620                 
Ser Ala His Ala Val Ser Leu Pro Pro Ala Ala Pro Ile Ser Tyr Arg
625                 630                 635                 640 
Leu Ala Glu Gln Gln Pro Leu Leu Arg His Pro Ala Pro Pro Gly Pro
                645                 650                 655     
Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Ala Asp Met Gln Arg
            660                 665                 670         
Ser Tyr Asp Ser Tyr Tyr Tyr Pro Ala Ala Gly Pro Gly Pro Arg Arg
        675                 680                 685             
Gly Thr Cys Ala Leu Gly Gly Ser Leu Gly Ser Leu Pro Ala Ser Pro
    690                 695                 700                 
Phe Arg Ile Pro Glu Asp Asp Glu Tyr Glu Thr Thr Gln Glu Cys Ala
705                 710                 715                 720 
Pro Pro Pro Pro Pro Arg Pro Arg Ala Arg Gly Ala Ser Arg Arg Thr
                725                 730                 735     
Ser Ala Gly Pro Arg Arg Trp Arg Arg Ser Arg Leu Asn Gly Leu Ala
            740                 745                 750         
Ala Gln Arg Ala Arg Ala Ala Arg Asp Ser Leu Ser Leu Ser Ser Gly
        755                 760                 765             
Ser Gly Gly Gly Ser Ala Ser Ala Ser Asp Asp Asp Ala Asp Asp Ala
    770                 775                 780                 
Asp Gly Ala Leu Ala Ala Glu Ser Thr Pro Phe Leu Gly Leu Arg Gly
785                 790                 795                 800 
Ala His Asp Ala Leu Arg Ser Asp Ser Pro Pro Leu Cys Pro Ala Ala
                805                 810                 815     
Asp Ser Arg Thr Tyr Tyr Ser Leu Asp Ser His Ser Thr Arg Ala Ser
            820                 825                 830         
Ser Arg His Ser Arg Gly Pro Pro Pro Arg Ala Lys Gln Asp Ser Ala
        835                 840                 845             
Pro Leu
    850 


<210> 611
<211> 551
<212> PRT
<213> Homo sapiens

<400> 611
Met Ala Gln Phe Val Gln Val Leu Ala Glu Ile Gly Asp Phe Gly Arg
 1               5                  10                  15      
Phe Gln Ile Gln Leu Leu Ile Leu Leu Cys Val Leu Asn Phe Leu Ser
            20                  25                  30          
Pro Phe Tyr Phe Phe Ala His Val Phe Met Val Leu Asp Glu Pro His
        35                  40                  45              
His Cys Ala Val Ala Trp Val Lys Asn His Thr Phe Asn Leu Ser Ala
    50                  55                  60                  
Ala Glu Gln Leu Val Leu Ser Val Pro Leu Asp Thr Ala Gly His Pro
65                  70                  75                  80  
Glu Pro Cys Leu Met Phe Arg Pro Pro Pro Ala Asn Ala Ser Leu Gln
                85                  90                  95      
Asp Ile Leu Ser His Arg Phe Asn Glu Thr Gln Pro Cys Asp Met Gly
            100                 105                 110         
Trp Glu Tyr Pro Glu Asn Arg Leu Pro Ser Leu Lys Asn Glu Phe Asn
        115                 120                 125             
Leu Val Cys Asp Arg Lys His Leu Lys Asp Thr Thr Gln Ser Val Phe
    130                 135                 140                 
Met Gly Gly Leu Leu Val Gly Thr Leu Met Phe Gly Pro Leu Cys Asp
145                 150                 155                 160 
Arg Ile Gly Arg Lys Ala Thr Ile Leu Ala Gln Leu Leu Leu Phe Thr
                165                 170                 175     
Leu Ile Gly Leu Ala Thr Ala Phe Val Pro Ser Phe Glu Leu Tyr Met
            180                 185                 190         
Ala Leu Arg Phe Ala Val Ala Thr Ala Val Ala Gly Leu Ser Phe Ser
        195                 200                 205             
Asn Val Thr Leu Leu Thr Glu Trp Val Gly Pro Ser Trp Arg Thr Gln
    210                 215                 220                 
Ala Val Val Leu Ala Gln Cys Asn Phe Ser Leu Gly Gln Met Val Leu
225                 230                 235                 240 
Ala Gly Leu Ala Tyr Gly Phe Arg Asn Trp Arg Leu Leu Gln Ile Thr
                245                 250                 255     
Gly Thr Ala Pro Gly Leu Leu Leu Phe Phe Tyr Phe Trp Ala Leu Pro
            260                 265                 270         
Glu Ser Ala Arg Trp Leu Leu Thr Arg Gly Arg Met Asp Glu Ala Ile
        275                 280                 285             
Gln Leu Ile Gln Lys Ala Ala Ser Val Asn Arg Arg Lys Leu Ser Pro
    290                 295                 300                 
Glu Leu Met Asn Gln Leu Val Pro Glu Lys Thr Gly Pro Ser Gly Asn
305                 310                 315                 320 
Ala Leu Asp Leu Phe Arg His Pro Gln Leu Arg Lys Val Thr Leu Ile
                325                 330                 335     
Ile Phe Cys Val Trp Phe Val Asp Ser Leu Gly Tyr Tyr Gly Leu Ser
            340                 345                 350         
Leu Gln Val Gly Asp Phe Gly Leu Asp Val Tyr Leu Thr Gln Leu Ile
        355                 360                 365             
Phe Gly Ala Val Glu Val Pro Ala Arg Cys Ser Ser Ile Phe Met Met
    370                 375                 380                 
Gln Arg Phe Gly Arg Lys Trp Ser Gln Leu Gly Thr Leu Val Leu Gly
385                 390                 395                 400 
Gly Leu Met Cys Ile Ile Ile Ile Phe Ile Pro Ala Asp Leu Pro Val
                405                 410                 415     
Val Val Thr Met Leu Ala Val Val Gly Lys Met Ala Thr Ala Ala Ala
            420                 425                 430         
Phe Thr Ile Ser Tyr Val Tyr Ser Ala Glu Leu Phe Pro Thr Ile Leu
        435                 440                 445             
Arg Gln Thr Gly Met Gly Leu Val Gly Ile Phe Ser Arg Ile Gly Gly
    450                 455                 460                 
Ile Leu Thr Pro Leu Val Ile Leu Leu Gly Glu Tyr His Ala Ala Leu
465                 470                 475                 480 
Pro Met Leu Ile Tyr Gly Ser Leu Pro Ile Val Ala Gly Leu Leu Cys
                485                 490                 495     
Thr Leu Leu Pro Glu Thr His Gly Gln Gly Leu Lys Asp Thr Leu Gln
            500                 505                 510         
Asp Leu Glu Leu Gly Pro His Pro Arg Ser Pro Lys Ser Val Pro Ser
        515                 520                 525             
Glu Lys Glu Thr Glu Ala Lys Gly Arg Thr Ser Ser Pro Gly Val Ala
    530                 535                 540                 
Phe Val Ser Ser Thr Tyr Phe
545                 550     


<210> 612
<211> 58
<212> PRT
<213> Homo sapiens

<400> 612
Met Leu Gln Ser Ile Ile Lys Asn Ile Trp Ile Pro Met Lys Pro Tyr
 1               5                  10                  15      
Tyr Thr Lys Val Tyr Gln Glu Ile Trp Ile Gly Met Gly Leu Met Gly
            20                  25                  30          
Phe Ile Val Tyr Lys Ile Arg Ala Ala Asp Lys Arg Ser Lys Ala Leu
        35                  40                  45              
Lys Ala Ser Ala Pro Ala Pro Gly His His
    50                  55              


<210> 613
<211> 58
<212> PRT
<213> Homo sapiens

<400> 613
Met Leu Gln Ser Ile Ile Lys Asn Ile Trp Ile Pro Met Lys Pro Tyr
 1               5                  10                  15      
Tyr Thr Lys Val Tyr Gln Glu Ile Trp Ile Gly Met Gly Leu Met Gly
            20                  25                  30          
Phe Ile Val Tyr Lys Ile Arg Ala Ala Asp Lys Arg Ser Lys Ala Leu
        35                  40                  45              
Lys Ala Ser Ala Pro Ala Pro Gly His His
    50                  55              


<210> 614
<211> 216
<212> PRT
<213> Homo sapiens

<400> 614
Met Ala Gly Arg Gly Gly Ala Arg Arg Pro Asn Gly Pro Ala Ala Gly
 1               5                  10                  15      
Asn Lys Ile Cys Gln Phe Lys Leu Val Leu Leu Gly Glu Ser Ala Val
            20                  25                  30          
Gly Lys Ser Ser Leu Val Leu Arg Phe Val Lys Gly Gln Phe His Glu
        35                  40                  45              
Tyr Gln Glu Ser Thr Ile Gly Ala Ala Phe Leu Thr Gln Thr Val Cys
    50                  55                  60                  
Leu Asp Asp Thr Thr Val Lys Phe Glu Ile Trp Asp Thr Ala Gly Gln
65                  70                  75                  80  
Glu Arg Tyr His Ser Leu Ala Pro Met Tyr Tyr Arg Gly Ala Gln Ala
                85                  90                  95      
Ala Ile Val Val Tyr Asp Ile Thr Asn Thr Asp Thr Phe Ala Arg Ala
            100                 105                 110         
Lys Asn Trp Val Lys Glu Leu Gln Arg Gln Ala Ser Pro Asn Ile Val
        115                 120                 125             
Ile Ala Leu Ala Gly Asn Lys Ala Asp Leu Ala Ser Lys Arg Ala Val
    130                 135                 140                 
Glu Phe Gln Glu Ala Gln Ala Tyr Ala Asp Asp Asn Ser Leu Leu Phe
145                 150                 155                 160 
Met Glu Thr Ser Ala Lys Thr Ala Met Asn Val Asn Glu Ile Phe Met
                165                 170                 175     
Ala Ile Ala Lys Lys Leu Pro Lys Asn Glu Pro Gln Asn Ala Thr Gly
            180                 185                 190         
Ala Pro Gly Arg Asn Arg Gly Val Asp Leu Gln Glu Asn Asn Pro Ala
        195                 200                 205             
Ser Arg Ser Gln Cys Cys Ser Asn
    210                 215     


<210> 615
<211> 301
<212> PRT
<213> Homo sapiens

<400> 615
Met Ala Met Leu Val Leu Val Pro Gly Arg Val Met Arg Pro Leu Gly
 1               5                  10                  15      
Gly Gln Leu Trp Arg Phe Leu Pro Arg Gly Leu Glu Phe Trp Gly Pro
            20                  25                  30          
Ala Glu Gly Thr Ala Arg Val Leu Leu Arg Gln Phe Cys Ala Arg Gln
        35                  40                  45              
Ala Glu Ala Trp Arg Ala Ser Gly Arg Pro Gly Tyr Cys Leu Gly Thr
    50                  55                  60                  
Arg Pro Leu Ser Thr Ala Arg Pro Pro Pro Pro Trp Ser Gln Lys Gly
65                  70                  75                  80  
Pro Gly Asp Ser Thr Arg Pro Ser Lys Pro Gly Pro Val Ser Trp Lys
                85                  90                  95      
Ser Leu Ala Ile Thr Phe Ala Ile Gly Gly Ala Leu Leu Ala Gly Met
            100                 105                 110         
Lys His Val Lys Lys Glu Lys Ala Glu Lys Leu Glu Lys Glu Arg Gln
        115                 120                 125             
Arg His Ile Gly Lys Pro Leu Leu Gly Gly Pro Phe Ser Leu Thr Thr
    130                 135                 140                 
His Thr Gly Glu Arg Lys Thr Asp Lys Asp Tyr Leu Gly Gln Trp Leu
145                 150                 155                 160 
Leu Ile Tyr Phe Gly Phe Thr His Cys Pro Asp Val Cys Pro Glu Glu
                165                 170                 175     
Leu Glu Lys Met Ile Gln Val Val Asp Glu Ile Asp Ser Ile Thr Thr
            180                 185                 190         
Leu Pro Asp Leu Thr Pro Leu Phe Ile Ser Ile Asp Pro Glu Arg Asp
        195                 200                 205             
Thr Lys Glu Ala Ile Ala Asn Tyr Val Lys Glu Phe Ser Pro Lys Leu
    210                 215                 220                 
Val Gly Leu Thr Gly Thr Arg Glu Glu Val Asp Gln Val Ala Arg Ala
225                 230                 235                 240 
Tyr Arg Val Tyr Tyr Ser Pro Gly Pro Lys Asp Glu Asp Glu Asp Tyr
                245                 250                 255     
Ile Val Asp His Thr Ile Ile Met Tyr Leu Ile Gly Pro Asp Gly Glu
            260                 265                 270         
Phe Leu Asp Tyr Phe Gly Gln Asn Lys Arg Lys Gly Glu Ile Ala Ala
        275                 280                 285             
Ser Ile Ala Thr His Met Arg Pro Tyr Arg Lys Lys Ser
    290                 295                 300     


<210> 616
<211> 664
<212> PRT
<213> Homo sapiens

<400> 616
Met Ser Gly Val Arg Gly Leu Ser Arg Leu Leu Ser Ala Arg Arg Leu
 1               5                  10                  15      
Ala Leu Ala Lys Ala Trp Pro Thr Val Leu Gln Thr Gly Thr Arg Gly
            20                  25                  30          
Phe His Phe Thr Val Asp Gly Asn Lys Arg Ala Ser Ala Lys Val Ser
        35                  40                  45              
Asp Ser Ile Ser Ala Gln Tyr Pro Val Val Asp His Glu Phe Asp Ala
    50                  55                  60                  
Val Val Val Gly Ala Gly Gly Ala Gly Leu Arg Ala Ala Phe Gly Leu
65                  70                  75                  80  
Ser Glu Ala Gly Phe Asn Thr Ala Cys Val Thr Lys Leu Phe Pro Thr
                85                  90                  95      
Arg Ser His Thr Val Ala Ala Gln Gly Gly Ile Asn Ala Ala Leu Gly
            100                 105                 110         
Asn Met Glu Glu Asp Asn Trp Arg Trp His Phe Tyr Asp Thr Val Lys
        115                 120                 125             
Gly Ser Asp Trp Leu Gly Asp Gln Asp Ala Ile His Tyr Met Thr Glu
    130                 135                 140                 
Gln Ala Pro Ala Ala Val Val Glu Leu Glu Asn Tyr Gly Met Pro Phe
145                 150                 155                 160 
Ser Arg Thr Glu Asp Gly Lys Ile Tyr Gln Arg Ala Phe Gly Gly Gln
                165                 170                 175     
Ser Leu Lys Phe Gly Lys Gly Gly Gln Ala His Arg Cys Cys Cys Val
            180                 185                 190         
Ala Asp Arg Thr Gly His Ser Leu Leu His Thr Leu Tyr Gly Arg Ser
        195                 200                 205             
Leu Arg Tyr Asp Thr Ser Tyr Phe Val Glu Tyr Phe Ala Leu Asp Leu
    210                 215                 220                 
Leu Met Glu Asn Gly Glu Cys Arg Gly Val Ile Ala Leu Cys Ile Glu
225                 230                 235                 240 
Asp Gly Ser Ile His Arg Ile Arg Ala Lys Asn Thr Val Val Ala Thr
                245                 250                 255     
Gly Gly Tyr Gly Arg Thr Tyr Phe Ser Cys Thr Ser Ala His Thr Ser
            260                 265                 270         
Thr Gly Asp Gly Thr Ala Met Ile Thr Arg Ala Gly Leu Pro Cys Gln
        275                 280                 285             
Asp Leu Glu Phe Val Gln Phe His Pro Thr Gly Ile Tyr Gly Ala Gly
    290                 295                 300                 
Cys Leu Ile Thr Glu Gly Cys Arg Gly Glu Gly Gly Ile Leu Ile Asn
305                 310                 315                 320 
Ser Gln Gly Glu Arg Phe Met Glu Arg Tyr Ala Pro Val Ala Lys Asp
                325                 330                 335     
Leu Ala Ser Arg Asp Val Val Ser Arg Ser Met Thr Leu Glu Ile Arg
            340                 345                 350         
Glu Gly Arg Gly Cys Gly Pro Glu Lys Asp His Val Tyr Leu Gln Leu
        355                 360                 365             
His His Leu Pro Pro Glu Gln Leu Ala Thr Arg Leu Pro Gly Ile Ser
    370                 375                 380                 
Glu Thr Ala Met Ile Phe Ala Gly Val Asp Val Thr Lys Glu Pro Ile
385                 390                 395                 400 
Pro Val Leu Pro Thr Val His Tyr Asn Met Gly Gly Ile Pro Thr Asn
                405                 410                 415     
Tyr Lys Gly Gln Val Leu Arg His Val Asn Gly Gln Asp Gln Ile Val
            420                 425                 430         
Pro Gly Leu Tyr Ala Cys Gly Glu Ala Ala Cys Ala Ser Val His Gly
        435                 440                 445             
Ala Asn Arg Leu Gly Ala Asn Ser Leu Leu Asp Leu Val Val Phe Gly
    450                 455                 460                 
Arg Ala Cys Ala Leu Ser Ile Glu Glu Ser Cys Arg Pro Gly Asp Lys
465                 470                 475                 480 
Val Pro Pro Ile Lys Pro Asn Ala Gly Glu Glu Ser Val Met Asn Leu
                485                 490                 495     
Asp Lys Leu Arg Phe Ala Asp Gly Ser Ile Arg Thr Ser Glu Leu Arg
            500                 505                 510         
Leu Ser Met Gln Lys Ser Met Gln Asn His Ala Ala Val Phe Arg Val
        515                 520                 525             
Gly Ser Val Leu Gln Glu Gly Cys Gly Lys Ile Ser Lys Leu Tyr Gly
    530                 535                 540                 
Asp Leu Lys His Leu Lys Thr Phe Asp Arg Gly Met Val Trp Asn Thr
545                 550                 555                 560 
Asp Leu Val Glu Thr Leu Glu Leu Gln Asn Leu Met Leu Cys Ala Leu
                565                 570                 575     
Gln Thr Ile Tyr Gly Ala Glu Ala Arg Lys Glu Ser Arg Gly Ala His
            580                 585                 590         
Ala Arg Glu Asp Tyr Lys Val Arg Ile Asp Glu Tyr Asp Tyr Ser Lys
        595                 600                 605             
Pro Ile Gln Gly Gln Gln Lys Lys Pro Phe Glu Glu His Trp Arg Lys
    610                 615                 620                 
His Thr Leu Ser Phe Val Asp Val Gly Thr Gly Lys Val Thr Leu Glu
625                 630                 635                 640 
Tyr Arg Pro Val Ile Asp Lys Thr Leu Asn Glu Ala Asp Cys Ala Thr
                645                 650                 655     
Ile Pro Pro Ala Ile Arg Ser Tyr
            660                 


<210> 617
<211> 664
<212> PRT
<213> Homo sapiens

<400> 617
Met Ser Gly Val Arg Gly Leu Ser Arg Leu Leu Ser Ala Arg Arg Leu
 1               5                  10                  15      
Ala Leu Ala Lys Ala Trp Pro Thr Val Leu Gln Thr Gly Thr Arg Gly
            20                  25                  30          
Phe His Phe Thr Val Asp Gly Asn Lys Arg Ala Ser Ala Lys Val Ser
        35                  40                  45              
Asp Ser Ile Ser Ala Gln Tyr Pro Val Val Asp His Glu Phe Asp Ala
    50                  55                  60                  
Val Val Val Gly Ala Gly Gly Ala Gly Leu Arg Ala Ala Phe Gly Leu
65                  70                  75                  80  
Ser Glu Ala Gly Phe Asn Thr Ala Cys Val Thr Lys Leu Phe Pro Thr
                85                  90                  95      
Arg Ser His Thr Val Ala Ala Gln Gly Gly Ile Asn Ala Ala Leu Gly
            100                 105                 110         
Asn Met Glu Glu Asp Asn Trp Arg Trp His Phe Tyr Asp Thr Val Lys
        115                 120                 125             
Gly Ser Asp Trp Leu Gly Asp Gln Asp Ala Ile His Tyr Met Thr Glu
    130                 135                 140                 
Gln Ala Pro Ala Ala Val Val Glu Leu Glu Asn Tyr Gly Met Pro Phe
145                 150                 155                 160 
Ser Arg Thr Glu Asp Gly Lys Ile Tyr Gln Arg Ala Phe Gly Gly Gln
                165                 170                 175     
Ser Leu Lys Phe Gly Lys Gly Gly Gln Ala His Arg Cys Cys Cys Val
            180                 185                 190         
Ala Asp Arg Thr Gly His Ser Leu Leu His Thr Leu Tyr Gly Arg Ser
        195                 200                 205             
Leu Arg Tyr Asp Thr Ser Tyr Phe Val Glu Tyr Phe Ala Leu Asp Leu
    210                 215                 220                 
Leu Met Glu Asn Gly Glu Cys Arg Gly Val Ile Ala Leu Cys Ile Glu
225                 230                 235                 240 
Asp Gly Ser Ile His Arg Ile Arg Ala Lys Asn Thr Val Val Ala Thr
                245                 250                 255     
Gly Gly Tyr Gly Arg Thr Tyr Phe Ser Cys Thr Ser Ala His Thr Ser
            260                 265                 270         
Thr Gly Asp Gly Thr Ala Met Ile Thr Arg Ala Gly Leu Pro Cys Gln
        275                 280                 285             
Asp Leu Glu Phe Val Gln Phe His Pro Thr Gly Ile Tyr Gly Ala Gly
    290                 295                 300                 
Cys Leu Ile Thr Glu Gly Cys Arg Gly Glu Gly Gly Ile Leu Ile Asn
305                 310                 315                 320 
Ser Gln Gly Glu Arg Phe Met Glu Arg Tyr Ala Pro Val Ala Lys Asp
                325                 330                 335     
Leu Ala Ser Arg Asp Val Val Ser Arg Ser Met Thr Leu Glu Ile Arg
            340                 345                 350         
Glu Gly Arg Gly Cys Gly Pro Glu Lys Asp His Val Tyr Leu Gln Leu
        355                 360                 365             
His His Leu Pro Pro Glu Gln Leu Ala Thr Arg Leu Pro Gly Ile Ser
    370                 375                 380                 
Glu Thr Ala Met Ile Phe Ala Gly Val Asp Val Thr Lys Glu Pro Ile
385                 390                 395                 400 
Pro Val Leu Pro Thr Val His Tyr Asn Met Gly Gly Ile Pro Thr Asn
                405                 410                 415     
Tyr Lys Gly Gln Val Leu Arg His Val Asn Gly Gln Asp Gln Ile Val
            420                 425                 430         
Pro Gly Leu Tyr Ala Cys Gly Glu Ala Ala Cys Ala Ser Val His Gly
        435                 440                 445             
Ala Asn Arg Leu Gly Ala Asn Ser Leu Leu Asp Leu Val Val Phe Gly
    450                 455                 460                 
Arg Ala Cys Ala Leu Ser Ile Glu Glu Ser Cys Arg Pro Gly Asp Lys
465                 470                 475                 480 
Val Pro Pro Ile Lys Pro Asn Ala Gly Glu Glu Ser Val Met Asn Leu
                485                 490                 495     
Asp Lys Leu Arg Phe Ala Asp Gly Ser Ile Arg Thr Ser Glu Leu Arg
            500                 505                 510         
Leu Ser Met Gln Lys Ser Met Gln Asn His Ala Ala Val Phe Arg Val
        515                 520                 525             
Gly Ser Val Leu Gln Glu Gly Cys Gly Lys Ile Ser Lys Leu Tyr Gly
    530                 535                 540                 
Asp Leu Lys His Leu Lys Thr Phe Asp Arg Gly Met Val Trp Asn Thr
545                 550                 555                 560 
Asp Leu Val Glu Thr Leu Glu Leu Gln Asn Leu Met Leu Cys Ala Leu
                565                 570                 575     
Gln Thr Ile Tyr Gly Ala Glu Ala Arg Lys Glu Ser Arg Gly Ala His
            580                 585                 590         
Ala Arg Glu Asp Tyr Lys Val Arg Ile Asp Glu Tyr Asp Tyr Ser Lys
        595                 600                 605             
Pro Ile Gln Gly Gln Gln Lys Lys Pro Phe Glu Glu His Trp Arg Lys
    610                 615                 620                 
His Thr Leu Ser Phe Val Asp Val Gly Thr Gly Lys Val Thr Leu Glu
625                 630                 635                 640 
Tyr Arg Pro Val Ile Asp Lys Thr Leu Asn Glu Ala Asp Cys Ala Thr
                645                 650                 655     
Ile Pro Pro Ala Ile Arg Ser Tyr
            660                 


<210> 618
<211> 425
<212> PRT
<213> Homo sapiens

<400> 618
Met Gly Glu Asp Ala Ala Gln Ala Glu Lys Phe Gln His Pro Gly Ser
 1               5                  10                  15      
Asp Met Arg Gln Glu Lys Pro Ser Ser Pro Ser Pro Met Pro Ser Ser
            20                  25                  30          
Thr Pro Ser Pro Ser Leu Asn Leu Gly Asn Thr Glu Glu Ala Ile Arg
        35                  40                  45              
Asp Asn Ser Gln Val Asn Ala Val Thr Val Leu Thr Leu Leu Asp Lys
    50                  55                  60                  
Leu Val Asn Met Leu Asp Ala Val Gln Glu Asn Gln His Lys Met Glu
65                  70                  75                  80  
Gln Arg Gln Ile Ser Leu Glu Gly Ser Val Lys Gly Ile Gln Asn Asp
                85                  90                  95      
Leu Thr Lys Leu Ser Lys Tyr Gln Ala Ser Thr Ser Asn Thr Val Ser
            100                 105                 110         
Lys Leu Leu Glu Lys Ser Arg Lys Val Ser Ala His Thr Arg Ala Val
        115                 120                 125             
Lys Glu Arg Met Asp Arg Gln Cys Ala Gln Val Lys Arg Leu Glu Asn
    130                 135                 140                 
Asn His Ala Gln Leu Leu Arg Arg Asn His Phe Lys Val Leu Ile Phe
145                 150                 155                 160 
Gln Glu Glu Asn Glu Ile Pro Ala Ser Val Phe Val Lys Gln Pro Val
                165                 170                 175     
Ser Gly Ala Val Glu Gly Lys Glu Glu Leu Pro Asp Glu Asn Lys Ser
            180                 185                 190         
Leu Glu Glu Thr Leu His Thr Val Asp Leu Ser Ser Asp Asp Asp Leu
        195                 200                 205             
Pro His Asp Glu Glu Ala Leu Glu Asp Ser Ala Glu Glu Lys Val Glu
    210                 215                 220                 
Glu Ser Arg Ala Glu Lys Ile Lys Arg Ser Ser Leu Lys Lys Val Asp
225                 230                 235                 240 
Ser Leu Lys Lys Ala Phe Ser Arg Gln Asn Ile Glu Lys Lys Met Asn
                245                 250                 255     
Lys Leu Gly Thr Lys Ile Val Ser Val Glu Arg Arg Glu Lys Ile Lys
            260                 265                 270         
Lys Ser Leu Thr Ser Asn His Gln Lys Ile Ser Ser Gly Lys Ser Ser
        275                 280                 285             
Pro Phe Lys Val Ser Pro Leu Thr Phe Gly Arg Lys Lys Val Arg Glu
    290                 295                 300                 
Gly Glu Ser His Ala Glu Asn Glu Thr Lys Ser Glu Asp Leu Pro Ser
305                 310                 315                 320 
Ser Glu Gln Met Pro Asn Asp Gln Glu Glu Glu Ser Phe Ala Glu Gly
                325                 330                 335     
His Ser Glu Ala Ser Leu Ala Ser Ala Leu Val Glu Gly Glu Ile Ala
            340                 345                 350         
Glu Glu Ala Ala Glu Lys Ala Thr Ser Arg Gly Ser Asn Ser Gly Met
        355                 360                 365             
Asp Ser Asn Ile Asp Leu Thr Ile Val Glu Asp Glu Glu Glu Glu Ser
    370                 375                 380                 
Val Ala Leu Glu Gln Ala Gln Lys Val Arg Tyr Glu Gly Ser Tyr Ala
385                 390                 395                 400 
Leu Thr Ser Glu Glu Ala Glu Arg Ser Asp Gly Asp Pro Val Gln Pro
                405                 410                 415     
Ala Val Leu Gln Val His Gln Thr Ser
            420                 425 


<210> 619
<211> 465
<212> PRT
<213> Homo sapiens

<400> 619
Met Gly Gly Ala Val Val Asp Glu Gly Pro Thr Gly Val Lys Ala Pro
 1               5                  10                  15      
Asp Gly Gly Trp Gly Trp Ala Val Leu Phe Gly Cys Phe Val Ile Thr
            20                  25                  30          
Gly Phe Ser Tyr Ala Phe Pro Lys Ala Val Ser Val Phe Phe Lys Glu
        35                  40                  45              
Leu Ile Gln Glu Phe Gly Ile Gly Tyr Ser Asp Thr Ala Trp Ile Ser
    50                  55                  60                  
Ser Ile Leu Leu Ala Met Leu Tyr Gly Thr Gly Pro Leu Cys Ser Val
65                  70                  75                  80  
Cys Val Asn Arg Phe Gly Cys Arg Pro Val Met Leu Val Gly Gly Leu
                85                  90                  95      
Phe Ala Ser Leu Gly Met Val Ala Ala Ser Phe Cys Arg Ser Ile Ile
            100                 105                 110         
Gln Val Tyr Leu Thr Thr Gly Val Ile Thr Gly Leu Gly Leu Ala Leu
        115                 120                 125             
Asn Phe Gln Pro Ser Leu Ile Met Leu Asn Arg Tyr Phe Ser Lys Arg
    130                 135                 140                 
Arg Pro Met Ala Asn Gly Leu Ala Ala Ala Gly Ser Pro Val Phe Leu
145                 150                 155                 160 
Cys Ala Leu Ser Pro Leu Gly Gln Leu Leu Gln Asp Arg Tyr Gly Trp
                165                 170                 175     
Arg Gly Gly Phe Leu Ile Leu Gly Gly Leu Leu Leu Asn Cys Cys Val
            180                 185                 190         
Cys Ala Ala Leu Met Arg Pro Leu Val Val Thr Ala Gln Pro Gly Ser
        195                 200                 205             
Gly Pro Pro Arg Pro Ser Arg Arg Leu Leu Asp Leu Ser Val Phe Arg
    210                 215                 220                 
Asp Arg Gly Phe Val Leu Tyr Ala Val Ala Ala Ser Val Met Val Leu
225                 230                 235                 240 
Gly Leu Phe Val Pro Pro Val Phe Val Val Ser Tyr Ala Lys Asp Leu
                245                 250                 255     
Gly Val Pro Asp Thr Lys Ala Ala Phe Leu Leu Thr Ile Leu Gly Phe
            260                 265                 270         
Ile Asp Ile Phe Ala Arg Pro Ala Ala Gly Phe Val Ala Gly Leu Gly
        275                 280                 285             
Lys Val Arg Pro Tyr Ser Val Tyr Leu Phe Ser Phe Ser Met Phe Phe
    290                 295                 300                 
Asn Gly Leu Ala Asp Leu Ala Gly Ser Thr Ala Gly Asp Tyr Gly Gly
305                 310                 315                 320 
Leu Val Val Phe Cys Ile Phe Phe Gly Ile Ser Tyr Gly Met Val Gly
                325                 330                 335     
Ala Leu Gln Phe Glu Val Leu Met Ala Ile Val Gly Thr His Lys Phe
            340                 345                 350         
Ser Ser Ala Ile Gly Leu Val Leu Leu Met Glu Ala Val Ala Val Leu
        355                 360                 365             
Val Gly Pro Pro Ser Gly Gly Lys Leu Leu Asp Ala Thr His Val Tyr
    370                 375                 380                 
Met Tyr Val Phe Ile Leu Ala Gly Ala Glu Val Leu Thr Ser Ser Leu
385                 390                 395                 400 
Ile Leu Leu Leu Gly Asn Phe Phe Cys Ile Arg Lys Lys Pro Lys Glu
                405                 410                 415     
Pro Gln Pro Glu Val Ala Ala Ala Glu Glu Glu Lys Leu His Lys Pro
            420                 425                 430         
Pro Ala Asp Ser Gly Val Asp Leu Arg Glu Val Glu His Phe Leu Lys
        435                 440                 445             
Ala Glu Pro Glu Lys Asn Gly Glu Val Val His Thr Pro Glu Thr Ser
    450                 455                 460                 
Val
465 


<210> 620
<211> 896
<212> PRT
<213> Homo sapiens

<400> 620
Met Leu Arg Ala Ala Leu Ser Leu Leu Ala Leu Pro Leu Ala Gly Ala
 1               5                  10                  15      
Ala Glu Glu Pro Thr Gln Lys Pro Glu Ser Pro Gly Glu Pro Pro Pro
            20                  25                  30          
Gly Leu Glu Leu Phe Arg Trp Gln Trp His Glu Val Glu Ala Pro Tyr
        35                  40                  45              
Leu Val Ala Leu Trp Ile Leu Val Ala Ser Leu Ala Lys Ile Val Phe
    50                  55                  60                  
His Leu Ser Arg Lys Val Thr Ser Leu Val Pro Glu Ser Cys Leu Leu
65                  70                  75                  80  
Ile Leu Leu Gly Leu Val Leu Gly Gly Ile Val Leu Ala Val Ala Lys
                85                  90                  95      
Lys Ala Glu Tyr Gln Leu Glu Pro Gly Thr Phe Phe Leu Phe Leu Leu
            100                 105                 110         
Pro Pro Ile Val Leu Asp Ser Gly Tyr Phe Met Pro Ser Arg Leu Phe
        115                 120                 125             
Phe Asp Asn Leu Gly Ala Ile Leu Thr Tyr Ala Val Val Gly Thr Leu
    130                 135                 140                 
Trp Asn Ala Phe Thr Thr Gly Ala Ala Leu Trp Gly Leu Gln Gln Ala
145                 150                 155                 160 
Gly Leu Val Ala Pro Arg Val Gln Ala Gly Leu Leu Asp Phe Leu Leu
                165                 170                 175     
Phe Gly Ser Leu Ile Ser Ala Val Asp Pro Val Ala Val Leu Ala Val
            180                 185                 190         
Phe Glu Glu Val His Val Asn Glu Thr Leu Phe Ile Ile Val Phe Gly
        195                 200                 205             
Glu Ser Leu Leu Asn Asp Ala Val Thr Val Val Leu Tyr Lys Val Cys
    210                 215                 220                 
Asn Ser Phe Val Glu Met Gly Ser Ala Asn Val Gln Ala Thr Asp Tyr
225                 230                 235                 240 
Leu Lys Gly Val Ala Ser Leu Phe Val Val Ser Leu Gly Gly Ala Ala
                245                 250                 255     
Val Gly Leu Val Phe Ala Phe Leu Leu Ala Leu Thr Thr Arg Phe Thr
            260                 265                 270         
Lys Arg Val Arg Ile Ile Glu Pro Leu Leu Val Phe Leu Leu Ala Tyr
        275                 280                 285             
Ala Ala Tyr Leu Thr Ala Glu Met Ala Ser Leu Ser Ala Ile Leu Ala
    290                 295                 300                 
Val Thr Met Cys Gly Leu Gly Cys Lys Lys Tyr Val Glu Ala Asn Ile
305                 310                 315                 320 
Ser His Lys Ser Arg Thr Thr Val Lys Tyr Thr Met Lys Thr Leu Ala
                325                 330                 335     
Ser Cys Ala Glu Thr Val Ile Phe Met Leu Leu Gly Ile Ser Ala Val
            340                 345                 350         
Asp Ser Ser Lys Trp Ala Trp Asp Ser Gly Leu Val Leu Gly Thr Leu
        355                 360                 365             
Ile Phe Ile Leu Phe Phe Arg Ala Leu Gly Val Val Leu Gln Thr Trp
    370                 375                 380                 
Val Leu Asn Gln Phe Arg Leu Val Pro Leu Asp Lys Ile Asp Gln Val
385                 390                 395                 400 
Val Met Ser Tyr Gly Gly Leu Arg Gly Ala Val Ala Phe Ala Leu Val
                405                 410                 415     
Ile Leu Leu Asp Arg Thr Lys Val Pro Ala Lys Asp Tyr Phe Val Ala
            420                 425                 430         
Thr Thr Ile Val Val Val Phe Phe Thr Val Ile Val Gln Gly Leu Thr
        435                 440                 445             
Ile Lys Pro Leu Val Lys Trp Leu Lys Val Lys Arg Ser Glu His His
    450                 455                 460                 
Lys Pro Thr Leu Asn Gln Glu Leu His Glu His Thr Phe Asp His Ile
465                 470                 475                 480 
Leu Ala Ala Val Glu Asp Val Val Gly His His Gly Tyr His Tyr Trp
                485                 490                 495     
Arg Asp Arg Trp Glu Gln Phe Asp Lys Lys Tyr Leu Ser Gln Leu Leu
            500                 505                 510         
Met Arg Arg Ser Ala Tyr Arg Ile Arg Asp Gln Ile Trp Asp Val Tyr
        515                 520                 525             
Tyr Arg Leu Asn Ile Arg Asp Ala Ile Ser Phe Val Asp Gln Gly Gly
    530                 535                 540                 
His Val Leu Ser Ser Thr Gly Leu Thr Leu Pro Ser Met Pro Ser Arg
545                 550                 555                 560 
Asn Ser Val Ala Glu Thr Ser Val Thr Asn Leu Leu Arg Glu Ser Gly
                565                 570                 575     
Ser Gly Ala Cys Leu Asp Leu Gln Val Ile Asp Thr Val Arg Ser Gly
            580                 585                 590         
Arg Asp Arg Glu Asp Ala Val Met His His Leu Leu Cys Gly Gly Leu
        595                 600                 605             
Tyr Lys Pro Arg Arg Arg Tyr Lys Ala Ser Cys Ser Arg His Phe Ile
    610                 615                 620                 
Ser Glu Asp Ala Gln Glu Arg Gln Asp Lys Glu Val Phe Gln Gln Asn
625                 630                 635                 640 
Met Lys Arg Arg Leu Glu Ser Phe Lys Ser Thr Lys His Asn Ile Cys
                645                 650                 655     
Phe Thr Lys Ser Lys Pro Arg Pro Arg Lys Thr Gly Arg Arg Lys Lys
            660                 665                 670         
Asp Gly Val Ala Asn Ala Glu Ala Thr Asn Gly Lys His Arg Gly Leu
        675                 680                 685             
Gly Phe Gln Asp Thr Ala Ala Val Ile Leu Thr Val Glu Ser Glu Glu
    690                 695                 700                 
Glu Glu Glu Glu Ser Asp Ser Ser Glu Thr Glu Lys Glu Asp Asp Glu
705                 710                 715                 720 
Gly Ile Ile Phe Val Ala Arg Ala Thr Ser Glu Val Leu Gln Glu Gly
                725                 730                 735     
Lys Val Ser Gly Ser Leu Glu Val Cys Pro Ser Pro Arg Ile Ile Pro
            740                 745                 750         
Pro Ser Pro Thr Cys Ala Glu Lys Glu Leu Pro Trp Lys Ser Gly Gln
        755                 760                 765             
Gly Asp Leu Ala Val Tyr Val Ser Ser Glu Thr Thr Lys Ile Val Pro
    770                 775                 780                 
Val Asp Met Gln Thr Gly Trp Asn Gln Ser Ile Ser Ser Leu Glu Ser
785                 790                 795                 800 
Leu Ala Ser Pro Pro Cys Asn Gln Ala Pro Ile Leu Thr Cys Leu Pro
                805                 810                 815     
Pro His Pro Arg Gly Thr Glu Glu Pro Gln Val Pro Leu His Leu Pro
            820                 825                 830         
Ser Asp Pro Arg Ser Ser Phe Ala Phe Pro Pro Ser Leu Ala Lys Ala
        835                 840                 845             
Gly Arg Ser Arg Ser Glu Ser Ser Ala Asp Leu Pro Gln Gln Gln Glu
    850                 855                 860                 
Leu Gln Pro Leu Met Gly His Lys Asp His Thr His Leu Ser Pro Gly
865                 870                 875                 880 
Thr Ala Thr Ser His Trp Cys Ile Gln Phe Asn Arg Gly Ser Arg Leu
                885                 890                 895     


<210> 621
<211> 1529
<212> PRT
<213> Homo sapiens

<400> 621
Met Arg Gly Val Gly Trp Gln Met Leu Ser Leu Ser Leu Gly Leu Val
 1               5                  10                  15      
Leu Ala Ile Leu Asn Lys Val Ala Pro Gln Ala Cys Pro Ala Gln Cys
            20                  25                  30          
Ser Cys Ser Gly Ser Thr Val Asp Cys His Gly Leu Ala Leu Arg Ser
        35                  40                  45              
Val Pro Arg Asn Ile Pro Arg Asn Thr Glu Arg Leu Asp Leu Asn Gly
    50                  55                  60                  
Asn Asn Ile Thr Arg Ile Thr Lys Thr Asp Phe Ala Gly Leu Arg His
65                  70                  75                  80  
Leu Arg Val Leu Gln Leu Met Glu Asn Lys Ile Ser Thr Ile Glu Arg
                85                  90                  95      
Gly Ala Phe Gln Asp Leu Lys Glu Leu Glu Arg Leu Arg Leu Asn Arg
            100                 105                 110         
Asn His Leu Gln Leu Phe Pro Glu Leu Leu Phe Leu Gly Thr Ala Lys
        115                 120                 125             
Leu Tyr Arg Leu Asp Leu Ser Glu Asn Gln Ile Gln Ala Ile Pro Arg
    130                 135                 140                 
Lys Ala Phe Arg Gly Ala Val Asp Ile Lys Asn Leu Gln Leu Asp Tyr
145                 150                 155                 160 
Asn Gln Ile Ser Cys Ile Glu Asp Gly Ala Phe Arg Ala Leu Arg Asp
                165                 170                 175     
Leu Glu Val Leu Thr Leu Asn Asn Asn Asn Ile Thr Arg Leu Ser Val
            180                 185                 190         
Ala Ser Phe Asn His Met Pro Lys Leu Arg Thr Phe Arg Leu His Ser
        195                 200                 205             
Asn Asn Leu Tyr Cys Asp Cys His Leu Ala Trp Leu Ser Asp Trp Leu
    210                 215                 220                 
Arg Gln Arg Pro Arg Val Gly Leu Tyr Thr Gln Cys Met Gly Pro Ser
225                 230                 235                 240 
His Leu Arg Gly His Asn Val Ala Glu Val Gln Lys Arg Glu Phe Val
                245                 250                 255     
Cys Ser Gly His Gln Ser Phe Met Ala Pro Ser Cys Ser Val Leu His
            260                 265                 270         
Cys Pro Ala Ala Cys Thr Cys Ser Asn Asn Ile Val Asp Cys Arg Gly
        275                 280                 285             
Lys Gly Leu Thr Glu Ile Pro Thr Asn Leu Pro Glu Thr Ile Thr Glu
    290                 295                 300                 
Ile Arg Leu Glu Gln Asn Thr Ile Lys Val Ile Pro Pro Gly Ala Phe
305                 310                 315                 320 
Ser Pro Tyr Lys Lys Leu Arg Arg Ile Asp Leu Ser Asn Asn Gln Ile
                325                 330                 335     
Ser Glu Leu Ala Pro Asp Ala Phe Gln Gly Leu Arg Ser Leu Asn Ser
            340                 345                 350         
Leu Val Leu Tyr Gly Asn Lys Ile Thr Glu Leu Pro Lys Ser Leu Phe
        355                 360                 365             
Glu Gly Leu Phe Ser Leu Gln Leu Leu Leu Leu Asn Ala Asn Lys Ile
    370                 375                 380                 
Asn Cys Leu Arg Val Asp Ala Phe Gln Asp Leu His Asn Leu Asn Leu
385                 390                 395                 400 
Leu Ser Leu Tyr Asp Asn Lys Leu Gln Thr Ile Ala Lys Gly Thr Phe
                405                 410                 415     
Ser Pro Leu Arg Ala Ile Gln Thr Met His Leu Ala Gln Asn Pro Phe
            420                 425                 430         
Ile Cys Asp Cys His Leu Lys Trp Leu Ala Asp Tyr Leu His Thr Asn
        435                 440                 445             
Pro Ile Glu Thr Ser Gly Ala Arg Cys Thr Ser Pro Arg Arg Leu Ala
    450                 455                 460                 
Asn Lys Arg Ile Gly Gln Ile Lys Ser Lys Lys Phe Arg Cys Ser Ala
465                 470                 475                 480 
Lys Glu Gln Tyr Phe Ile Pro Gly Thr Glu Asp Tyr Arg Ser Lys Leu
                485                 490                 495     
Ser Gly Asp Cys Phe Ala Asp Leu Ala Cys Pro Glu Lys Cys Arg Cys
            500                 505                 510         
Glu Gly Thr Thr Val Asp Cys Ser Asn Gln Lys Leu Asn Lys Ile Pro
        515                 520                 525             
Glu His Ile Pro Gln Tyr Thr Ala Glu Leu Arg Leu Asn Asn Asn Glu
    530                 535                 540                 
Phe Thr Val Leu Glu Ala Thr Gly Ile Phe Lys Lys Leu Pro Gln Leu
545                 550                 555                 560 
Arg Lys Ile Asn Phe Ser Asn Asn Lys Ile Thr Asp Ile Glu Glu Gly
                565                 570                 575     
Ala Phe Glu Gly Ala Ser Gly Val Asn Glu Ile Leu Leu Thr Ser Asn
            580                 585                 590         
Arg Leu Glu Asn Val Gln His Lys Met Phe Lys Gly Leu Glu Ser Leu
        595                 600                 605             
Lys Thr Leu Met Leu Arg Ser Asn Arg Ile Thr Cys Val Gly Asn Asp
    610                 615                 620                 
Ser Phe Ile Gly Leu Ser Ser Val Arg Leu Leu Ser Leu Tyr Asp Asn
625                 630                 635                 640 
Gln Ile Thr Thr Val Ala Pro Gly Ala Phe Asp Thr Leu His Ser Leu
                645                 650                 655     
Ser Thr Leu Asn Leu Leu Ala Asn Pro Phe Asn Cys Asn Cys Tyr Leu
            660                 665                 670         
Ala Trp Leu Gly Glu Trp Leu Arg Lys Lys Arg Ile Val Thr Gly Asn
        675                 680                 685             
Pro Arg Cys Gln Lys Pro Tyr Phe Leu Lys Glu Ile Pro Ile Gln Asp
    690                 695                 700                 
Val Ala Ile Gln Asp Phe Thr Cys Asp Asp Gly Asn Asp Asp Asn Ser
705                 710                 715                 720 
Cys Ser Pro Leu Ser Arg Cys Pro Thr Glu Cys Thr Cys Leu Asp Thr
                725                 730                 735     
Val Val Arg Cys Ser Asn Lys Gly Leu Lys Val Leu Pro Lys Gly Ile
            740                 745                 750         
Pro Arg Asp Val Thr Glu Leu Tyr Leu Asp Gly Asn Gln Phe Thr Leu
        755                 760                 765             
Val Pro Lys Glu Leu Ser Asn Tyr Lys His Leu Thr Leu Ile Asp Leu
    770                 775                 780                 
Ser Asn Asn Arg Ile Ser Thr Leu Ser Asn Gln Ser Phe Ser Asn Met
785                 790                 795                 800 
Thr Gln Leu Leu Thr Leu Ile Leu Ser Tyr Asn Arg Leu Arg Cys Ile
                805                 810                 815     
Pro Pro Arg Thr Phe Asp Gly Leu Lys Ser Leu Arg Leu Leu Ser Leu
            820                 825                 830         
His Gly Asn Asp Ile Ser Val Val Pro Glu Gly Ala Phe Asn Asp Leu
        835                 840                 845             
Ser Ala Leu Ser His Leu Ala Ile Gly Ala Asn Pro Leu Tyr Cys Asp
    850                 855                 860                 
Cys Asn Met Gln Trp Leu Ser Asp Trp Val Lys Ser Glu Tyr Lys Glu
865                 870                 875                 880 
Pro Gly Ile Ala Arg Cys Ala Gly Pro Gly Glu Met Ala Asp Lys Leu
                885                 890                 895     
Leu Leu Thr Thr Pro Ser Lys Lys Phe Thr Cys Gln Gly Pro Val Asp
            900                 905                 910         
Val Asn Ile Leu Ala Lys Cys Asn Pro Cys Leu Ser Asn Pro Cys Lys
        915                 920                 925             
Asn Asp Gly Thr Cys Asn Ser Asp Pro Val Asp Phe Tyr Arg Cys Thr
    930                 935                 940                 
Cys Pro Tyr Gly Phe Lys Gly Gln Asp Cys Asp Val Pro Ile His Ala
945                 950                 955                 960 
Cys Ile Ser Asn Pro Cys Lys His Gly Gly Thr Cys His Leu Lys Glu
                965                 970                 975     
Gly Glu Glu Asp Gly Phe Trp Cys Ile Cys Ala Asp Gly Phe Glu Gly
            980                 985                 990         
Glu Asn Cys Glu Val Asn Val Asp Asp Cys Glu Asp Asn Asp Cys Glu
        995                 1000                1005            
Asn Asn Ser Thr Cys Val Asp Gly Ile Asn Asn Tyr Thr Cys Leu Cys
    1010                1015                1020                
Pro Pro Glu Tyr Thr Gly Glu Leu Cys Glu Glu Lys Leu Asp Phe Cys
1025                1030                1035                1040
Ala Gln Asp Leu Asn Pro Cys Gln His Asp Ser Lys Cys Ile Leu Thr
                1045                1050                1055    
Pro Lys Gly Phe Lys Cys Asp Cys Thr Pro Gly Tyr Val Gly Glu His
            1060                1065                1070        
Cys Asp Ile Asp Phe Asp Asp Cys Gln Asp Asn Lys Cys Lys Asn Gly
        1075                1080                1085            
Ala His Cys Thr Asp Ala Val Asn Gly Tyr Thr Cys Ile Cys Pro Glu
    1090                1095                1100                
Gly Tyr Ser Gly Leu Phe Cys Glu Phe Ser Pro Pro Met Val Leu Pro
1105                1110                1115                1120
Arg Thr Ser Pro Cys Asp Asn Phe Asp Cys Gln Asn Gly Ala Gln Cys
                1125                1130                1135    
Ile Val Arg Ile Asn Glu Pro Ile Cys Gln Cys Leu Pro Gly Tyr Gln
            1140                1145                1150        
Gly Glu Lys Cys Glu Lys Leu Val Ser Val Asn Phe Ile Asn Lys Glu
        1155                1160                1165            
Ser Tyr Leu Gln Ile Pro Ser Ala Lys Val Arg Pro Gln Thr Asn Ile
    1170                1175                1180                
Thr Leu Gln Ile Ala Thr Asp Glu Asp Ser Gly Ile Leu Leu Tyr Lys
1185                1190                1195                1200
Gly Asp Lys Asp His Ile Ala Val Glu Leu Tyr Arg Gly Arg Val Arg
                1205                1210                1215    
Ala Ser Tyr Asp Thr Gly Ser His Pro Ala Ser Ala Ile Tyr Ser Val
            1220                1225                1230        
Glu Thr Ile Asn Asp Gly Asn Phe His Ile Val Glu Leu Leu Ala Leu
        1235                1240                1245            
Asp Gln Ser Leu Ser Leu Ser Val Asp Gly Gly Asn Pro Lys Ile Ile
    1250                1255                1260                
Thr Asn Leu Ser Lys Gln Ser Thr Leu Asn Phe Asp Ser Pro Leu Tyr
1265                1270                1275                1280
Val Gly Gly Met Pro Gly Lys Ser Asn Val Ala Ser Leu Arg Gln Ala
                1285                1290                1295    
Pro Gly Gln Asn Gly Thr Ser Phe His Gly Cys Ile Arg Asn Leu Tyr
            1300                1305                1310        
Ile Asn Ser Glu Leu Gln Asp Phe Gln Lys Val Pro Met Gln Thr Gly
        1315                1320                1325            
Ile Leu Pro Gly Cys Glu Pro Cys His Lys Lys Val Cys Ala His Gly
    1330                1335                1340                
Thr Cys Gln Pro Ser Ser Gln Ala Gly Phe Thr Cys Glu Cys Gln Glu
1345                1350                1355                1360
Gly Trp Met Gly Pro Leu Cys Asp Gln Arg Thr Asn Asp Pro Cys Leu
                1365                1370                1375    
Gly Asn Lys Cys Val His Gly Thr Cys Leu Pro Ile Asn Ala Phe Ser
            1380                1385                1390        
Tyr Ser Cys Lys Cys Leu Glu Gly His Gly Gly Val Leu Cys Asp Glu
        1395                1400                1405            
Glu Glu Asp Leu Phe Asn Pro Cys Gln Ala Ile Lys Cys Lys His Gly
    1410                1415                1420                
Lys Cys Arg Leu Ser Gly Leu Gly Gln Pro Tyr Cys Glu Cys Ser Ser
1425                1430                1435                1440
Gly Tyr Thr Gly Asp Ser Cys Asp Arg Glu Ile Ser Cys Arg Gly Glu
                1445                1450                1455    
Arg Ile Arg Asp Tyr Tyr Gln Lys Gln Gln Gly Tyr Ala Ala Cys Gln
            1460                1465                1470        
Thr Thr Lys Lys Val Ser Arg Leu Glu Cys Arg Gly Gly Cys Ala Gly
        1475                1480                1485            
Gly Gln Cys Cys Gly Pro Leu Arg Ser Lys Arg Arg Lys Tyr Ser Phe
    1490                1495                1500                
Glu Cys Thr Asp Gly Ser Ser Phe Val Asp Glu Val Glu Lys Val Val
1505                1510                1515                1520
Lys Cys Gly Cys Thr Arg Cys Val Ser
                1525                


<210> 622
<211> 126
<212> PRT
<213> Homo sapiens

<400> 622
Met Ser Ile Gly Val Pro Ile Lys Val Leu His Glu Ala Glu Gly His
 1               5                  10                  15      
Ile Val Thr Cys Glu Thr Asn Thr Gly Glu Val Tyr Arg Gly Lys Leu
            20                  25                  30          
Ile Glu Ala Glu Asp Asn Met Asn Cys Gln Met Ser Asn Ile Thr Val
        35                  40                  45              
Thr Tyr Arg Asp Gly Arg Val Ala Gln Leu Glu Gln Val Tyr Ile Arg
    50                  55                  60                  
Gly Ser Lys Ile Arg Phe Leu Ile Leu Pro Asp Met Leu Lys Asn Ala
65                  70                  75                  80  
Pro Met Leu Lys Ser Met Lys Asn Lys Asn Gln Gly Ser Gly Ala Gly
                85                  90                  95      
Arg Gly Lys Ala Ala Ile Leu Lys Ala Gln Val Ala Ala Arg Gly Arg
            100                 105                 110         
Gly Arg Gly Met Gly Arg Gly Asn Ile Phe Gln Lys Arg Arg
        115                 120                 125     


<210> 623
<211> 1142
<212> PRT
<213> Homo sapiens

<400> 623
Met Thr Gln Leu Tyr Lys Val Ala Leu Gln Trp Met Val Lys Ser Arg
 1               5                  10                  15      
Val Ile Ser Glu Leu Gln Glu Ala Cys Trp Asp Met Val Ser Ala Met
            20                  25                  30          
Ala Gly Asp Ile Ile Leu Leu Leu Asp Ser Asp Asn Asp Gly Ile Arg
        35                  40                  45              
Thr His Ala Ile Lys Phe Val Glu Gly Leu Ile Val Thr Leu Ser Pro
    50                  55                  60                  
Arg Met Ala Asp Ser Glu Ile Pro Arg Arg Gln Glu His Asp Ile Ser
65                  70                  75                  80  
Leu Asp Arg Ile Pro Arg Asp His Pro Tyr Ile Gln Tyr Asn Val Leu
                85                  90                  95      
Trp Glu Glu Gly Lys Ala Ala Leu Glu Gln Leu Leu Lys Phe Met Val
            100                 105                 110         
His Pro Ala Ile Ser Ser Ile Asn Leu Thr Thr Ala Leu Gly Ser Leu
        115                 120                 125             
Ala Asn Ile Ala Arg Gln Arg Pro Met Phe Met Ser Glu Val Ile Gln
    130                 135                 140                 
Ala Tyr Glu Thr Leu His Ala Asn Leu Pro Pro Thr Leu Ala Lys Ser
145                 150                 155                 160 
Gln Val Ser Ser Val Arg Lys Asn Leu Lys Leu His Leu Leu Ser Val
                165                 170                 175     
Leu Lys His Pro Ala Ser Leu Glu Phe Gln Ala Gln Ile Thr Thr Leu
            180                 185                 190         
Leu Val Asp Leu Gly Thr Pro Gln Ala Glu Ile Ala Arg Asn Met Pro
        195                 200                 205             
Ser Ser Lys Asp Thr Arg Lys Arg Pro Arg Asp Asp Ser Asp Ser Thr
    210                 215                 220                 
Leu Lys Lys Met Lys Leu Glu Pro Asn Leu Gly Glu Asp Asp Glu Asp
225                 230                 235                 240 
Lys Asp Leu Glu Pro Gly Pro Ser Gly Thr Ser Lys Ala Ser Ala Gln
                245                 250                 255     
Ile Ser Gly Gln Ser Asp Thr Asp Ile Thr Ala Glu Phe Leu Gln Pro
            260                 265                 270         
Leu Leu Thr Pro Asp Asn Val Ala Asn Leu Val Leu Ile Ser Met Val
        275                 280                 285             
Tyr Leu Pro Glu Ala Met Pro Ala Ser Phe Gln Ala Ile Tyr Thr Pro
    290                 295                 300                 
Val Glu Ser Ala Gly Thr Glu Ala Gln Ile Lys His Leu Ala Arg Leu
305                 310                 315                 320 
Met Ala Thr Gln Met Thr Ala Ala Gly Leu Gly Pro Gly Val Glu Gln
                325                 330                 335     
Thr Lys Gln Cys Lys Glu Glu Pro Lys Glu Glu Lys Val Val Lys Thr
            340                 345                 350         
Glu Ser Val Leu Ile Lys Arg Arg Leu Ser Ala Gln Gly Gln Ala Ile
        355                 360                 365             
Ser Val Val Gly Ser Leu Ser Ser Met Ser Pro Leu Glu Glu Glu Ala
    370                 375                 380                 
Pro Gln Ala Lys Arg Arg Pro Glu Pro Ile Ile Pro Val Thr Gln Pro
385                 390                 395                 400 
Arg Leu Ala Gly Ala Gly Gly Arg Lys Lys Ile Phe Arg Leu Ser Asp
                405                 410                 415     
Val Leu Lys Pro Leu Thr Asp Ala Gln Val Glu Ala Met Lys Leu Gly
            420                 425                 430         
Ala Val Lys Arg Ile Leu Arg Ala Glu Lys Ala Val Ala Cys Ser Gly
        435                 440                 445             
Ala Ala Gln Val Arg Ile Lys Ile Leu Ala Ser Leu Val Thr Gln Phe
    450                 455                 460                 
Asn Ser Gly Leu Lys Ala Glu Val Leu Ser Phe Ile Leu Glu Asp Val
465                 470                 475                 480 
Arg Ala Arg Leu Asp Leu Ala Phe Ala Trp Leu Tyr Gln Glu Tyr Asn
                485                 490                 495     
Ala Tyr Leu Ala Ala Gly Ala Ser Gly Ser Leu Asp Lys Tyr Glu Asp
            500                 505                 510         
Cys Leu Ile Arg Leu Leu Ser Gly Leu Gln Glu Lys Pro Asp Gln Lys
        515                 520                 525             
Asp Gly Ile Phe Thr Lys Val Val Leu Glu Ala Pro Leu Ile Thr Glu
    530                 535                 540                 
Ser Ala Leu Glu Val Val Arg Lys Tyr Cys Glu Asp Glu Ser Arg Thr
545                 550                 555                 560 
Tyr Leu Gly Met Ser Thr Leu Arg Asp Leu Ile Phe Lys Arg Pro Ser
                565                 570                 575     
Arg Gln Phe Gln Tyr Leu His Val Leu Leu Asp Leu Ser Ser His Glu
            580                 585                 590         
Lys Asp Lys Val Arg Ser Gln Ala Leu Leu Phe Ile Lys Arg Met Tyr
        595                 600                 605             
Glu Lys Glu Gln Leu Arg Glu Tyr Val Glu Lys Phe Ala Leu Asn Tyr
    610                 615                 620                 
Leu Gln Leu Leu Val His Pro Asn Pro Pro Ser Val Leu Phe Gly Ala
625                 630                 635                 640 
Asp Lys Asp Thr Glu Val Ala Ala Pro Trp Thr Glu Glu Thr Val Lys
                645                 650                 655     
Gln Cys Leu Tyr Leu Tyr Leu Ala Leu Leu Pro Gln Asn His Lys Leu
            660                 665                 670         
Ile His Glu Leu Ala Ala Val Tyr Thr Glu Ala Ile Ala Asp Ile Lys
        675                 680                 685             
Arg Thr Val Leu Arg Val Ile Glu Gln Pro Ile Arg Gly Met Gly Met
    690                 695                 700                 
Asn Ser Pro Glu Leu Leu Leu Leu Val Glu Asn Cys Pro Lys Gly Ala
705                 710                 715                 720 
Glu Thr Leu Val Thr Arg Cys Leu His Ser Leu Thr Asp Lys Val Pro
                725                 730                 735     
Pro Ser Pro Glu Leu Val Lys Arg Val Arg Asp Leu Tyr His Lys Arg
            740                 745                 750         
Leu Pro Asp Val Arg Phe Leu Ile Pro Val Leu Asn Gly Leu Glu Lys
        755                 760                 765             
Lys Glu Val Ile Gln Ala Leu Pro Lys Leu Ile Lys Leu Asn Pro Ile
    770                 775                 780                 
Val Val Lys Glu Val Phe Asn Arg Leu Leu Gly Thr Gln His Gly Glu
785                 790                 795                 800 
Gly Asn Ser Ala Leu Ser Pro Leu Asn Pro Gly Glu Leu Leu Ile Ala
                805                 810                 815     
Leu His Asn Ile Asp Ser Val Lys Cys Asp Met Lys Ser Ile Ile Lys
            820                 825                 830         
Ala Thr Asn Leu Cys Phe Ala Glu Arg Asn Val Tyr Thr Ser Glu Val
        835                 840                 845             
Leu Ala Val Val Met Gln Gln Leu Met Glu Gln Ser Pro Leu Pro Met
    850                 855                 860                 
Leu Leu Met Arg Thr Val Ile Gln Ser Leu Thr Met Tyr Pro Arg Leu
865                 870                 875                 880 
Gly Gly Phe Val Met Asn Ile Leu Ser Arg Leu Ile Met Lys Gln Val
                885                 890                 895     
Trp Lys Tyr Pro Lys Val Trp Glu Gly Phe Ile Lys Cys Cys Gln Arg
            900                 905                 910         
Thr Lys Pro Gln Ser Phe Gln Val Ile Leu Gln Leu Pro Pro Gln Gln
        915                 920                 925             
Leu Gly Ala Val Phe Asp Lys Cys Pro Glu Leu Arg Glu Pro Leu Leu
    930                 935                 940                 
Ala His Val Arg Ser Phe Thr Pro His Gln Gln Ala His Ile Pro Asn
945                 950                 955                 960 
Ser Ile Met Thr Ile Leu Glu Ala Ser Gly Lys Gln Glu Pro Glu Ala
                965                 970                 975     
Lys Glu Ala Pro Ala Gly Pro Leu Glu Glu Asp Asp Leu Glu Pro Leu
            980                 985                 990         
Thr Leu Ala Pro Ala Pro Ala Pro Arg Pro Pro Gln Asp Leu Ile Gly
        995                 1000                1005            
Leu Arg Leu Ala Gln Glu Lys Ala Leu Lys Arg Gln Leu Glu Glu Glu
    1010                1015                1020                
Gln Lys Leu Lys Pro Gly Gly Val Gly Ala Pro Ser Ser Ser Ser Pro
1025                1030                1035                1040
Ser Pro Ser Pro Ser Ala Arg Pro Gly Pro Pro Pro Ser Glu Glu Ala
                1045                1050                1055    
Met Asp Phe Arg Glu Glu Gly Pro Glu Cys Glu Thr Pro Gly Ile Phe
            1060                1065                1070        
Ile Ser Met Asp Asp Asp Ser Gly Leu Thr Glu Ala Ala Leu Leu Asp
        1075                1080                1085            
Ser Ser Leu Glu Gly Pro Leu Pro Lys Glu Thr Ala Ala Gly Gly Leu
    1090                1095                1100                
Thr Leu Lys Glu Glu Arg Ser Pro Gln Thr Leu Ala Pro Val Gly Glu
1105                1110                1115                1120
Asp Ala Met Lys Thr Pro Ser Pro Ala Ala Glu Asp Ala Arg Glu Pro
                1125                1130                1135    
Glu Ala Lys Gly Asn Ser
            1140        


<210> 624
<211> 2265
<212> PRT
<213> Homo sapiens

<400> 624
Met Val Ser Ile Asp Leu His Gln Ala Gly Arg Val Asp Ser Gln Ala
 1               5                  10                  15      
Ser Ile Thr Gln Asp Ser Asp Ser Ile Lys Lys Pro Glu Glu Ile Lys
            20                  25                  30          
Gln Cys Asn Asp Ala Pro Val Ser Val Leu Gln Glu Asp Ile Val Gly
        35                  40                  45              
Ser Leu Lys Ser Thr Pro Glu Asn His Pro Glu Thr Pro Lys Lys Lys
    50                  55                  60                  
Ser Asp Pro Glu Leu Ser Lys Ser Glu Met Lys Gln Ser Glu Ser Arg
65                  70                  75                  80  
Leu Ala Glu Ser Lys Pro Asn Glu Asn Arg Leu Val Glu Thr Lys Ser
                85                  90                  95      
Ser Glu Asn Lys Leu Glu Thr Lys Val Glu Thr Gln Thr Glu Glu Leu
            100                 105                 110         
Lys Gln Asn Glu Ser Arg Thr Thr Glu Cys Lys Gln Asn Glu Ser Thr
        115                 120                 125             
Ile Val Glu Pro Lys Gln Asn Glu Asn Arg Leu Ser Asp Thr Lys Pro
    130                 135                 140                 
Asn Asp Asn Lys Gln Asn Asn Gly Arg Ser Glu Thr Thr Lys Ser Arg
145                 150                 155                 160 
Pro Glu Thr Pro Lys Gln Lys Gly Glu Ser Arg Pro Glu Thr Pro Lys
                165                 170                 175     
Gln Lys Ser Asp Gly His Pro Glu Thr Pro Lys Gln Lys Gly Asp Gly
            180                 185                 190         
Arg Pro Glu Thr Pro Lys Gln Lys Gly Glu Ser Arg Pro Glu Thr Pro
        195                 200                 205             
Lys Gln Lys Asn Glu Gly Arg Pro Glu Thr Pro Lys His Arg His Asp
    210                 215                 220                 
Asn Arg Arg Asp Ser Gly Lys Pro Ser Thr Glu Lys Lys Pro Glu Val
225                 230                 235                 240 
Ser Lys His Lys Gln Asp Thr Lys Ser Asp Ser Pro Arg Leu Lys Ser
                245                 250                 255     
Glu Arg Ala Glu Ala Leu Lys Gln Arg Pro Asp Gly Arg Ser Val Ser
            260                 265                 270         
Glu Ser Leu Arg Arg Asp His Asp Asn Lys Gln Lys Ser Asp Asp Arg
        275                 280                 285             
Gly Glu Ser Glu Arg His Arg Gly Asp Gln Ser Arg Val Arg Arg Pro
    290                 295                 300                 
Glu Thr Leu Arg Ser Ser Ser Arg Asn Glu His Gly Ile Lys Ser Asp
305                 310                 315                 320 
Ser Ser Lys Thr Asp Lys Leu Glu Arg Lys His Arg His Glu Ser Gly
                325                 330                 335     
Asp Ser Arg Glu Arg Pro Ser Ser Gly Glu Gln Lys Ser Arg Pro Asp
            340                 345                 350         
Ser Pro Arg Val Lys Gln Gly Asp Ser Asn Lys Ser Arg Ser Asp Lys
        355                 360                 365             
Leu Gly Phe Lys Ser Pro Thr Ser Lys Asp Asp Lys Arg Thr Glu Gly
    370                 375                 380                 
Asn Lys Ser Lys Val Asp Thr Asn Lys Ala His Pro Asp Asn Lys Ala
385                 390                 395                 400 
Glu Phe Pro Ser Tyr Leu Leu Gly Gly Arg Ser Gly Ala Leu Lys Asn
                405                 410                 415     
Phe Val Ile Pro Lys Ile Lys Arg Asp Lys Asp Gly Asn Val Thr Gln
            420                 425                 430         
Glu Thr Lys Lys Met Glu Met Lys Gly Glu Pro Lys Asp Lys Val Glu
        435                 440                 445             
Lys Ile Gly Leu Val Glu Asp Leu Asn Lys Gly Ala Lys Pro Val Val
    450                 455                 460                 
Val Leu Gln Lys Leu Ser Leu Asp Asp Val Gln Lys Leu Ile Lys Asp
465                 470                 475                 480 
Arg Glu Asp Lys Ser Arg Ser Ser Leu Lys Pro Ile Lys Asn Lys Pro
                485                 490                 495     
Ser Lys Ser Asn Lys Gly Ser Ile Asp Gln Ser Val Leu Lys Glu Leu
            500                 505                 510         
Pro Pro Glu Leu Leu Ala Glu Ile Glu Ser Thr Met Pro Leu Cys Glu
        515                 520                 525             
Arg Val Lys Met Asn Lys Arg Lys Arg Ser Thr Val Asn Glu Lys Pro
    530                 535                 540                 
Lys Tyr Ala Glu Ile Ser Ser Asp Glu Asp Asn Asp Ser Asp Glu Ala
545                 550                 555                 560 
Phe Glu Ser Ser Arg Lys Arg His Lys Lys Asp Asp Asp Lys Ala Trp
                565                 570                 575     
Glu Tyr Glu Glu Arg Asp Arg Arg Ser Ser Gly Asp His Arg Arg Ser
            580                 585                 590         
Gly His Ser His Glu Gly Arg Arg Ser Ser Gly Gly Gly Arg Tyr Arg
        595                 600                 605             
Asn Arg Ser Pro Ser Asp Ser Asp Met Glu Asp Tyr Ser Pro Pro Pro
    610                 615                 620                 
Ser Leu Ser Glu Val Ala Arg Lys Met Lys Lys Lys Glu Lys Gln Lys
625                 630                 635                 640 
Lys Arg Lys Ala Tyr Glu Pro Lys Leu Thr Pro Glu Glu Met Met Asp
                645                 650                 655     
Ser Ser Thr Phe Lys Arg Phe Thr Ala Ser Ile Glu Asn Ile Leu Asp
            660                 665                 670         
Asn Leu Glu Asp Met Asp Phe Thr Ala Phe Gly Asp Asp Asp Glu Ile
        675                 680                 685             
Pro Gln Glu Leu Leu Leu Gly Lys His Gln Leu Asn Glu Leu Gly Ser
    690                 695                 700                 
Glu Ser Ala Lys Ile Lys Ala Met Gly Ile Met Asp Lys Leu Ser Thr
705                 710                 715                 720 
Asp Lys Thr Val Lys Val Leu Asn Ile Leu Glu Lys Asn Ile Gln Asp
                725                 730                 735     
Gly Ser Lys Leu Ser Thr Leu Leu Asn His Asn Asn Asp Thr Glu Glu
            740                 745                 750         
Glu Glu Arg Leu Trp Arg Asp Leu Ile Met Glu Arg Val Thr Lys Ser
        755                 760                 765             
Ala Asp Ala Cys Leu Thr Thr Ile Asn Ile Met Thr Ser Pro Asn Met
    770                 775                 780                 
Pro Lys Ala Val Tyr Ile Glu Asp Val Ile Glu Arg Val Ile Gln Tyr
785                 790                 795                 800 
Thr Lys Phe His Leu Gln Asn Thr Leu Tyr Pro Gln Tyr Asp Pro Val
                805                 810                 815     
Tyr Arg Leu Asp Pro His Gly Gly Gly Leu Leu Ser Ser Lys Ala Lys
            820                 825                 830         
Arg Ala Lys Cys Ser Thr His Lys Gln Arg Val Ile Val Met Leu Tyr
        835                 840                 845             
Asn Lys Val Cys Asp Ile Val Ser Ser Leu Ser Glu Leu Leu Glu Ile
    850                 855                 860                 
Gln Leu Leu Thr Asp Thr Thr Ile Leu Gln Val Ser Ser Met Gly Ile
865                 870                 875                 880 
Thr Pro Phe Phe Val Glu Asn Val Ser Glu Leu Gln Leu Cys Ala Ile
                885                 890                 895     
Lys Leu Val Thr Ala Val Phe Ser Arg Tyr Glu Lys His Arg Gln Leu
            900                 905                 910         
Ile Leu Glu Glu Ile Phe Thr Ser Leu Ala Arg Leu Pro Thr Ser Lys
        915                 920                 925             
Arg Ser Leu Arg Asn Phe Arg Leu Asn Ser Ser Asp Met Asp Gly Glu
    930                 935                 940                 
Pro Met Tyr Ile Gln Met Val Thr Ala Leu Val Leu Gln Leu Ile Gln
945                 950                 955                 960 
Cys Val Val His Leu Pro Ser Ser Glu Lys Asp Ser Asn Ala Glu Glu
                965                 970                 975     
Asp Ser Asn Lys Lys Ile Asp Gln Asp Val Val Ile Thr Asn Ser Tyr
            980                 985                 990         
Glu Thr Ala Met Arg Thr Ala Gln Asn Phe Leu Ser Ile Phe Leu Lys
        995                 1000                1005            
Lys Cys Gly Ser Lys Gln Gly Glu Glu Asp Tyr Arg Pro Leu Phe Glu
    1010                1015                1020                
Asn Phe Val Gln Asp Leu Leu Ser Thr Val Asn Lys Pro Glu Trp Pro
1025                1030                1035                1040
Ala Ala Glu Leu Leu Leu Ser Leu Leu Gly Arg Leu Leu Val His Gln
                1045                1050                1055    
Phe Ser Asn Lys Ser Thr Glu Met Ala Leu Arg Val Ala Ser Leu Asp
            1060                1065                1070        
Tyr Leu Gly Thr Val Ala Ala Arg Leu Arg Lys Asp Ala Val Thr Ser
        1075                1080                1085            
Lys Met Asp Gln Gly Ser Ile Glu Arg Ile Leu Lys Gln Val Ser Gly
    1090                1095                1100                
Gly Glu Asp Glu Ile Gln Gln Leu Gln Lys Ala Leu Leu Asp Tyr Leu
1105                1110                1115                1120
Asp Glu Asn Thr Glu Thr Asp Pro Ser Leu Val Phe Ser Arg Lys Phe
                1125                1130                1135    
Tyr Ile Ala Gln Trp Phe Arg Asp Thr Thr Leu Glu Thr Glu Lys Ala
            1140                1145                1150        
Met Lys Ser Gln Lys Asp Glu Glu Ser Ser Glu Gly Thr His His Ala
        1155                1160                1165            
Lys Glu Ile Glu Thr Thr Gly Gln Ile Met His Arg Ala Glu Asn Arg
    1170                1175                1180                
Lys Lys Phe Leu Arg Ser Ile Ile Lys Thr Thr Pro Ser Gln Phe Ser
1185                1190                1195                1200
Thr Leu Lys Met Asn Ser Asp Thr Val Asp Tyr Asp Asp Ala Cys Leu
                1205                1210                1215    
Ile Val Arg Tyr Leu Ala Ser Met Arg Pro Phe Ala Gln Ser Phe Asp
            1220                1225                1230        
Ile Tyr Leu Thr Gln Ile Leu Arg Val Leu Gly Glu Asn Ala Ile Ala
        1235                1240                1245            
Val Arg Thr Lys Ala Met Lys Cys Leu Ser Glu Val Val Ala Val Asp
    1250                1255                1260                
Pro Ser Ile Leu Ala Arg Leu Asp Met Gln Arg Gly Val His Gly Arg
1265                1270                1275                1280
Leu Met Asp Asn Ser Thr Ser Val Arg Glu Ala Ala Val Glu Leu Leu
                1285                1290                1295    
Gly Arg Phe Val Leu Cys Arg Pro Gln Leu Ala Glu Gln Tyr Tyr Asp
            1300                1305                1310        
Met Leu Ile Glu Arg Ile Leu Asp Thr Gly Ile Ser Val Arg Lys Arg
        1315                1320                1325            
Val Ile Lys Ile Leu Arg Asp Ile Cys Ile Glu Gln Pro Thr Phe Pro
    1330                1335                1340                
Lys Ile Thr Glu Met Cys Val Lys Met Ile Arg Arg Val Asn Asp Glu
1345                1350                1355                1360
Glu Gly Ile Lys Lys Leu Val Asn Glu Thr Phe Gln Lys Leu Trp Phe
                1365                1370                1375    
Thr Pro Thr Pro His Asn Asp Lys Glu Ala Met Thr Arg Lys Ile Leu
            1380                1385                1390        
Asn Ile Thr Asp Val Val Ala Ala Cys Arg Asp Thr Gly Tyr Asp Trp
        1395                1400                1405            
Phe Glu Gln Leu Leu Gln Asn Leu Leu Lys Ser Glu Glu Asp Ser Ser
    1410                1415                1420                
Tyr Lys Pro Val Lys Lys Ala Cys Thr Gln Leu Val Asp Asn Leu Val
1425                1430                1435                1440
Glu His Ile Leu Lys Tyr Glu Glu Ser Leu Ala Asp Ser Asp Asn Lys
                1445                1450                1455    
Gly Val Asn Ser Gly Arg Leu Val Ala Cys Ile Thr Thr Leu Phe Leu
            1460                1465                1470        
Phe Ser Lys Ile Arg Pro Gln Leu Met Val Lys His Ala Met Thr Met
        1475                1480                1485            
Gln Pro Tyr Leu Thr Thr Lys Cys Ser Thr Gln Asn Asp Phe Met Val
    1490                1495                1500                
Ile Cys Asn Val Ala Lys Ile Leu Glu Leu Val Val Pro Leu Met Glu
1505                1510                1515                1520
His Pro Ser Glu Thr Phe Leu Ala Thr Ile Glu Glu Asp Leu Met Lys
                1525                1530                1535    
Leu Ile Ile Lys Tyr Gly Met Thr Val Val Gln His Cys Val Ser Cys
            1540                1545                1550        
Leu Gly Ala Val Val Asn Lys Val Thr Gln Asn Phe Lys Phe Val Trp
        1555                1560                1565            
Ala Cys Phe Asn Arg Tyr Tyr Gly Ala Ile Ser Lys Leu Lys Ser Gln
    1570                1575                1580                
His Gln Glu Asp Pro Asn Asn Thr Ser Leu Leu Thr Asn Lys Pro Ala
1585                1590                1595                1600
Leu Leu Arg Ser Leu Phe Thr Val Gly Ala Leu Cys Arg His Phe Asp
                1605                1610                1615    
Phe Asp Leu Glu Asp Phe Lys Gly Asn Ser Lys Val Asn Ile Lys Asp
            1620                1625                1630        
Lys Val Leu Glu Leu Leu Met Tyr Phe Thr Lys His Ser Asp Glu Glu
        1635                1640                1645            
Val Gln Thr Lys Ala Ile Ile Gly Leu Gly Phe Ala Phe Ile Gln His
    1650                1655                1660                
Pro Ser Leu Met Phe Glu Gln Glu Val Lys Asn Leu Tyr Asn Asn Ile
1665                1670                1675                1680
Leu Ser Asp Lys Asn Ser Ser Val Asn Leu Lys Ile Gln Val Leu Lys
                1685                1690                1695    
Asn Leu Gln Thr Tyr Leu Gln Glu Glu Asp Thr Arg Met Gln Gln Ala
            1700                1705                1710        
Asp Arg Asp Trp Lys Lys Val Ala Lys Gln Glu Asp Leu Lys Glu Met
        1715                1720                1725            
Gly Asp Val Ser Ser Gly Met Ser Ser Ser Ile Met Gln Leu Tyr Leu
    1730                1735                1740                
Lys Gln Val Leu Glu Ala Phe Phe His Thr Gln Ser Ser Val Arg His
1745                1750                1755                1760
Phe Ala Leu Asn Val Ile Ala Leu Thr Leu Asn Gln Gly Leu Ile His
                1765                1770                1775    
Pro Val Gln Cys Val Pro Tyr Leu Ile Ala Met Gly Thr Asp Pro Glu
            1780                1785                1790        
Pro Ala Met Arg Asn Lys Ala Asp Gln Gln Leu Val Glu Ile Asp Lys
        1795                1800                1805            
Lys Tyr Ala Gly Phe Ile His Met Lys Ala Val Ala Gly Met Lys Met
    1810                1815                1820                
Ser Tyr Gln Val Gln Gln Ala Ile Asn Thr Cys Leu Lys Asp Pro Val
1825                1830                1835                1840
Arg Gly Phe Arg Gln Asp Glu Ser Ser Ser Ala Leu Cys Ser His Leu
                1845                1850                1855    
Tyr Ser Met Ile Arg Gly Asn Arg Gln His Arg Arg Ala Phe Leu Ile
            1860                1865                1870        
Ser Leu Leu Asn Leu Phe Asp Asp Thr Ala Lys Thr Asp Val Thr Met
        1875                1880                1885            
Leu Leu Tyr Ile Ala Asp Asn Leu Ala Cys Phe Pro Tyr Gln Thr Gln
    1890                1895                1900                
Glu Glu Pro Leu Phe Ile Met His His Ile Asp Ile Thr Leu Ser Val
1905                1910                1915                1920
Ser Gly Ser Asn Leu Leu Gln Ser Phe Lys Glu Ser Met Val Lys Asp
                1925                1930                1935    
Lys Arg Lys Glu Arg Lys Ser Ser Pro Ser Lys Glu Asn Glu Ser Ser
            1940                1945                1950        
Asp Ser Glu Glu Glu Val Ser Arg Pro Arg Lys Ser Arg Lys Arg Val
        1955                1960                1965            
Asp Ser Asp Ser Asp Ser Asp Ser Glu Asp Asp Ile Asn Ser Val Met
    1970                1975                1980                
Lys Cys Leu Pro Glu Asn Ser Ala Pro Leu Ile Glu Phe Ala Asn Val
1985                1990                1995                2000
Ser Gln Gly Ile Leu Leu Leu Leu Met Leu Lys Gln His Leu Lys Asn
                2005                2010                2015    
Leu Cys Gly Phe Ser Asp Ser Lys Ile Gln Lys Tyr Ser Pro Ser Glu
            2020                2025                2030        
Ser Ala Lys Val Tyr Asp Lys Ala Ile Asn Arg Lys Thr Gly Val His
        2035                2040                2045            
Phe His Pro Lys Gln Thr Leu Asp Phe Leu Arg Ser Asp Met Ala Asn
    2050                2055                2060                
Ser Lys Ile Thr Glu Glu Val Lys Arg Ser Ile Val Lys Gln Tyr Leu
2065                2070                2075                2080
Asp Phe Lys Leu Leu Met Glu His Leu Asp Pro Asp Glu Glu Glu Glu
                2085                2090                2095    
Glu Gly Glu Val Ser Ala Ser Thr Asn Ala Arg Asn Lys Ala Ile Thr
            2100                2105                2110        
Ser Leu Leu Gly Gly Gly Ser Pro Lys Asn Asn Thr Ala Ala Glu Thr
        2115                2120                2125            
Glu Asp Asp Glu Ser Asp Gly Glu Asp Arg Gly Gly Gly Thr Ser Gly
    2130                2135                2140                
Ser Leu Arg Arg Ser Lys Arg Asn Ser Asp Ser Thr Glu Leu Ala Ala
2145                2150                2155                2160
Gln Met Asn Glu Ser Val Asp Val Met Asp Val Ile Ala Ile Cys Cys
                2165                2170                2175    
Pro Lys Tyr Lys Asp Arg Pro Gln Ile Ala Arg Val Val Gln Lys Thr
            2180                2185                2190        
Ser Ser Gly Phe Ser Val Gln Trp Met Ala Gly Ser Tyr Ser Gly Ser
        2195                2200                2205            
Trp Thr Glu Ala Lys Arg Arg Asp Gly Arg Lys Leu Val Pro Trp Val
    2210                2215                2220                
Asp Thr Ile Lys Glu Ser Asp Ile Ile Tyr Lys Lys Ile Ala Leu Thr
2225                2230                2235                2240
Ser Ala Asn Lys Leu Thr Asn Lys Val Val Gln Thr Leu Arg Ser Leu
                2245                2250                2255    
Tyr Ala Ala Lys Asp Gly Thr Ser Ser
            2260                2265


<210> 625
<211> 2243
<212> PRT
<213> Homo sapiens

<400> 625
Met Asp Glu Glu Glu Asp Gly Ala Gly Ala Glu Glu Ser Gly Gln Pro
 1               5                  10                  15      
Arg Ser Phe Met Arg Leu Asn Asp Leu Ser Gly Ala Gly Gly Arg Pro
            20                  25                  30          
Gly Pro Gly Ser Ala Glu Lys Asp Pro Gly Ser Ala Asp Ser Glu Ala
        35                  40                  45              
Glu Gly Leu Pro Tyr Pro Ala Leu Ala Pro Val Val Phe Phe Tyr Leu
    50                  55                  60                  
Ser Gln Asp Ser Arg Pro Arg Ser Trp Cys Leu Arg Thr Val Cys Asn
65                  70                  75                  80  
Pro Trp Phe Glu Arg Ile Ser Met Leu Val Ile Leu Leu Asn Cys Val
                85                  90                  95      
Thr Leu Gly Met Phe Arg Pro Cys Glu Asp Ile Ala Cys Asp Ser Gln
            100                 105                 110         
Arg Cys Arg Ile Leu Gln Ala Phe Asp Asp Phe Ile Phe Ala Phe Phe
        115                 120                 125             
Ala Val Glu Met Val Val Lys Met Val Ala Leu Gly Ile Phe Gly Lys
    130                 135                 140                 
Lys Cys Tyr Leu Gly Asp Thr Trp Asn Arg Leu Asp Phe Phe Ile Val
145                 150                 155                 160 
Ile Ala Gly Met Leu Glu Tyr Ser Leu Asp Leu Gln Asn Val Ser Phe
                165                 170                 175     
Ser Ala Val Arg Thr Val Arg Val Leu Arg Pro Leu Arg Ala Ile Asn
            180                 185                 190         
Arg Val Pro Ser Met Arg Ile Leu Val Thr Leu Leu Leu Asp Thr Leu
        195                 200                 205             
Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile
    210                 215                 220                 
Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg
225                 230                 235                 240 
Cys Phe Leu Pro Glu Asn Phe Ser Leu Pro Leu Ser Val Asp Leu Glu
                245                 250                 255     
Arg Tyr Tyr Gln Thr Glu Asn Glu Asp Glu Ser Pro Phe Ile Cys Ser
            260                 265                 270         
Gln Pro Arg Glu Asn Gly Met Arg Ser Cys Arg Ser Val Pro Thr Leu
        275                 280                 285             
Arg Gly Asp Gly Gly Gly Gly Pro Pro Cys Gly Leu Asp Tyr Glu Ala
    290                 295                 300                 
Tyr Asn Ser Ser Ser Asn Thr Thr Cys Val Asn Trp Asn Gln Tyr Tyr
305                 310                 315                 320 
Thr Asn Cys Ser Ala Gly Glu His Asn Pro Phe Lys Gly Ala Ile Asn
                325                 330                 335     
Phe Asp Asn Ile Gly Tyr Ala Trp Ile Ala Ile Phe Gln Val Ile Thr
            340                 345                 350         
Leu Glu Gly Trp Val Asp Ile Met Tyr Phe Val Met Asp Ala His Ser
        355                 360                 365             
Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val Gly Ser Phe
    370                 375                 380                 
Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Thr Gln Phe Ser Glu
385                 390                 395                 400 
Thr Lys Gln Arg Glu Ser Gln Leu Met Arg Glu Gln Arg Val Arg Phe
                405                 410                 415     
Leu Ser Asn Ala Ser Thr Leu Ala Ser Phe Ser Glu Pro Gly Ser Cys
            420                 425                 430         
Tyr Glu Glu Leu Leu Lys Tyr Leu Val Tyr Ile Leu Arg Lys Ala Ala
        435                 440                 445             
Arg Arg Leu Ala Gln Val Ser Arg Ala Ala Gly Val Arg Val Gly Leu
    450                 455                 460                 
Leu Ser Ser Pro Ala Pro Leu Gly Gly Gln Glu Thr Gln Pro Ser Ser
465                 470                 475                 480 
Ser Cys Ser Arg Ser His Arg Arg Leu Ser Val His His Leu Val His
                485                 490                 495     
His His His His His His His His Tyr His Leu Gly Asn Gly Thr Leu
            500                 505                 510         
Arg Ala Pro Arg Ala Ser Pro Glu Ile Gln Asp Arg Asp Ala Asn Gly
        515                 520                 525             
Ser Arg Arg Leu Met Leu Pro Pro Pro Ser Thr Pro Ala Leu Ser Gly
    530                 535                 540                 
Ala Pro Pro Gly Gly Ala Glu Ser Val His Ser Phe Tyr His Ala Asp
545                 550                 555                 560 
Cys His Leu Glu Pro Val Arg Cys Gln Ala Pro Pro Pro Arg Ser Pro
                565                 570                 575     
Ser Glu Ala Ser Gly Arg Thr Val Gly Ser Gly Lys Val Tyr Pro Thr
            580                 585                 590         
Val His Thr Ser Pro Pro Pro Glu Thr Leu Lys Glu Lys Ala Leu Val
        595                 600                 605             
Glu Val Ala Ala Ser Ser Gly Pro Pro Thr Leu Thr Ser Leu Asn Ile
    610                 615                 620                 
Pro Pro Gly Pro Tyr Ser Ser Met His Lys Leu Leu Glu Thr Gln Ser
625                 630                 635                 640 
Thr Gly Ala Cys Gln Ser Ser Cys Lys Ile Ser Ser Pro Cys Leu Lys
                645                 650                 655     
Ala Asp Ser Gly Ala Cys Gly Pro Asp Ser Cys Pro Tyr Cys Ala Arg
            660                 665                 670         
Ala Gly Ala Gly Glu Val Glu Leu Ala Asp Arg Glu Met Pro Asp Ser
        675                 680                 685             
Asp Ser Glu Ala Val Tyr Glu Phe Thr Gln Asp Ala Gln His Ser Asp
    690                 695                 700                 
Leu Arg Asp Pro His Ser Arg Arg Gln Arg Ser Leu Gly Pro Asp Ala
705                 710                 715                 720 
Glu Pro Ser Ser Val Leu Ala Phe Trp Arg Leu Ile Cys Asp Thr Phe
                725                 730                 735     
Arg Lys Ile Val Asp Ser Lys Tyr Phe Gly Arg Gly Ile Met Ile Ala
            740                 745                 750         
Ile Leu Val Asn Thr Leu Ser Met Gly Ile Glu Tyr His Glu Gln Pro
        755                 760                 765             
Glu Glu Leu Thr Asn Ala Leu Glu Ile Ser Asn Ile Val Phe Thr Ser
    770                 775                 780                 
Leu Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Val Tyr Gly Pro Phe
785                 790                 795                 800 
Gly Tyr Ile Lys Asn Pro Tyr Asn Ile Phe Asp Gly Val Ile Val Val
                805                 810                 815     
Ile Ser Val Trp Glu Ile Val Gly Gln Gln Gly Gly Gly Leu Ser Val
            820                 825                 830         
Leu Arg Thr Phe Arg Leu Met Arg Val Leu Lys Leu Val Arg Phe Leu
        835                 840                 845             
Pro Ala Leu Gln Arg Gln Leu Val Val Leu Met Lys Thr Met Asp Asn
    850                 855                 860                 
Val Ala Thr Phe Cys Met Leu Leu Met Leu Phe Ile Phe Ile Phe Ser
865                 870                 875                 880 
Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ala Ser Glu Arg Asp
                885                 890                 895     
Gly Asp Thr Leu Pro Asp Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala
            900                 905                 910         
Ile Val Thr Val Phe Gln Ile Leu Thr Gln Glu Asp Trp Asn Lys Val
        915                 920                 925             
Leu Tyr Asn Gly Met Ala Ser Thr Ser Ser Trp Ala Ala Leu Tyr Phe
    930                 935                 940                 
Ile Ala Leu Met Thr Phe Gly Asn Tyr Val Leu Phe Asn Leu Leu Val
945                 950                 955                 960 
Ala Ile Leu Val Glu Gly Phe Gln Ala Glu Gly Asp Ala Asn Lys Ser
                965                 970                 975     
Glu Ser Glu Pro Asp Phe Phe Ser Pro Ser Leu Asp Gly Asp Gly Asp
            980                 985                 990         
Arg Lys Lys Cys Leu Ala Leu Val Ser Leu Gly Glu His Pro Glu Leu
        995                 1000                1005            
Arg Lys Ser Leu Leu Pro Pro Leu Ile Ile His Thr Ala Ala Thr Pro
    1010                1015                1020                
Met Ser Leu Pro Lys Ser Thr Ser Thr Gly Leu Gly Glu Ala Leu Gly
1025                1030                1035                1040
Pro Ala Ser Arg Arg Thr Ser Ser Ser Gly Ser Ala Glu Pro Gly Ala
                1045                1050                1055    
Ala His Glu Met Lys Ser Pro Pro Ser Ala Arg Ser Ser Pro His Ser
            1060                1065                1070        
Pro Trp Ser Ala Ala Ser Ser Trp Thr Ser Arg Arg Ser Ser Arg Asn
        1075                1080                1085            
Ser Leu Gly Arg Ala Pro Ser Leu Lys Arg Arg Ser Pro Ser Gly Glu
    1090                1095                1100                
Arg Arg Ser Leu Leu Ser Gly Glu Gly Gln Glu Ser Gln Asp Glu Glu
1105                1110                1115                1120
Glu Ser Ser Glu Glu Glu Arg Ala Ser Pro Ala Gly Ser Asp His Arg
                1125                1130                1135    
His Arg Gly Ser Leu Glu Arg Glu Ala Lys Ser Ser Phe Asp Leu Pro
            1140                1145                1150        
Asp Thr Leu Gln Val Pro Gly Leu His Arg Thr Ala Ser Gly Arg Gly
        1155                1160                1165            
Ser Ala Ser Glu His Gln Asp Cys Asn Gly Lys Ser Ala Ser Gly Arg
    1170                1175                1180                
Leu Ala Arg Ala Leu Arg Pro Asp Asp Pro Pro Leu Asp Gly Asp Asp
1185                1190                1195                1200
Ala Asp Asp Glu Gly Asn Leu Ser Lys Gly Glu Arg Val Arg Ala Trp
                1205                1210                1215    
Ile Arg Ala Arg Leu Pro Ala Cys Cys Leu Glu Arg Asp Ser Trp Ser
            1220                1225                1230        
Ala Tyr Ile Phe Pro Pro Gln Ser Arg Phe Arg Leu Leu Cys His Arg
        1235                1240                1245            
Ile Ile Thr His Lys Met Phe Asp His Val Val Leu Val Ile Ile Phe
    1250                1255                1260                
Leu Asn Cys Ile Thr Ile Ala Met Glu Arg Pro Lys Ile Asp Pro His
1265                1270                1275                1280
Ser Ala Glu Arg Ile Phe Leu Thr Leu Ser Asn Tyr Ile Phe Thr Ala
                1285                1290                1295    
Val Phe Leu Ala Glu Met Thr Val Lys Val Val Ala Leu Gly Trp Cys
            1300                1305                1310        
Phe Gly Glu Gln Ala Tyr Leu Arg Ser Ser Trp Asn Val Leu Asp Gly
        1315                1320                1325            
Leu Leu Val Leu Ile Ser Val Ile Asp Ile Leu Val Ser Met Val Ser
    1330                1335                1340                
Asp Ser Gly Thr Lys Ile Leu Gly Met Leu Arg Val Leu Arg Leu Leu
1345                1350                1355                1360
Arg Thr Leu Arg Pro Leu Arg Val Ile Ser Arg Ala Gln Gly Leu Lys
                1365                1370                1375    
Leu Val Val Glu Thr Leu Met Ser Ser Leu Lys Pro Ile Gly Asn Ile
            1380                1385                1390        
Val Val Ile Cys Cys Ala Phe Phe Ile Ile Phe Gly Ile Leu Gly Val
        1395                1400                1405            
Gln Leu Phe Lys Gly Lys Phe Phe Val Cys Gln Gly Glu Asp Thr Arg
    1410                1415                1420                
Asn Ile Thr Asn Lys Ser Asp Cys Ala Glu Ala Ser Tyr Arg Trp Val
1425                1430                1435                1440
Arg His Lys Tyr Asn Phe Asp Asn Leu Gly Gln Ala Leu Met Ser Leu
                1445                1450                1455    
Phe Val Leu Ala Ser Lys Asp Gly Trp Val Asp Ile Met Tyr Asp Gly
            1460                1465                1470        
Leu Asp Ala Val Gly Val Asp Gln Gln Pro Ile Met Asn His Asn Pro
        1475                1480                1485            
Trp Met Leu Leu Tyr Phe Ile Ser Phe Leu Leu Ile Val Ala Phe Phe
    1490                1495                1500                
Val Leu Asn Met Phe Val Gly Val Val Val Glu Asn Phe His Lys Cys
1505                1510                1515                1520
Arg Gln His Gln Glu Glu Glu Glu Ala Arg Arg Arg Glu Glu Lys Arg
                1525                1530                1535    
Leu Arg Arg Leu Glu Lys Lys Arg Arg Lys Ala Gln Cys Lys Pro Tyr
            1540                1545                1550        
Tyr Ser Asp Tyr Ser Arg Phe Arg Leu Leu Val His His Leu Cys Thr
        1555                1560                1565            
Ser His Tyr Leu Asp Leu Phe Ile Thr Gly Val Ile Gly Leu Asn Val
    1570                1575                1580                
Val Thr Met Ala Met Glu His Tyr Gln Gln Pro Gln Ile Leu Asp Glu
1585                1590                1595                1600
Ala Leu Lys Ile Cys Asn Tyr Ile Phe Thr Val Ile Phe Val Leu Glu
                1605                1610                1615    
Ser Val Phe Lys Leu Val Ala Phe Gly Phe Arg Arg Phe Phe Gln Asp
            1620                1625                1630        
Arg Trp Asn Gln Leu Asp Leu Ala Ile Val Leu Leu Ser Ile Met Gly
        1635                1640                1645            
Ile Thr Leu Glu Glu Ile Glu Val Asn Ala Ser Leu Pro Ile Asn Pro
    1650                1655                1660                
Thr Ile Ile Arg Ile Met Arg Val Leu Arg Ile Ala Arg Val Leu Lys
1665                1670                1675                1680
Leu Leu Lys Met Ala Val Gly Met Arg Ala Leu Leu Asp Thr Val Met
                1685                1690                1695    
Gln Ala Leu Pro Gln Val Gly Asn Leu Gly Leu Leu Phe Met Leu Leu
            1700                1705                1710        
Phe Phe Ile Phe Ala Ala Leu Gly Val Glu Leu Phe Gly Asp Leu Glu
        1715                1720                1725            
Cys Asp Glu Thr His Pro Cys Glu Gly Leu Gly Arg His Ala Thr Phe
    1730                1735                1740                
Arg Asn Phe Gly Met Ala Phe Leu Thr Leu Phe Arg Val Ser Thr Gly
1745                1750                1755                1760
Asp Asn Trp Asn Gly Ile Met Lys Asp Thr Leu Arg Asp Cys Asp Gln
                1765                1770                1775    
Glu Ser Thr Cys Tyr Asn Thr Val Ile Ser Pro Ile Tyr Phe Val Ser
            1780                1785                1790        
Phe Val Leu Thr Ala Gln Phe Val Leu Val Asn Val Val Ile Ala Val
        1795                1800                1805            
Leu Met Lys His Leu Glu Glu Ser Asn Lys Glu Ala Lys Glu Glu Ala
    1810                1815                1820                
Glu Leu Glu Ala Glu Leu Glu Leu Glu Met Lys Thr Leu Ser Pro Gln
1825                1830                1835                1840
Pro His Ser Pro Leu Gly Ser Pro Phe Leu Trp Pro Gly Val Glu Gly
                1845                1850                1855    
Pro Asp Ser Pro Asp Ser Pro Lys Pro Gly Ala Leu His Pro Ala Ala
            1860                1865                1870        
His Ala Arg Ser Ala Ser His Phe Ser Leu Glu His Pro Thr Met Gln
        1875                1880                1885            
Pro His Pro Thr Glu Leu Pro Gly Pro Asp Leu Leu Thr Val Arg Lys
    1890                1895                1900                
Ser Gly Val Ser Arg Thr His Ser Leu Pro Asn Asp Ser Tyr Met Cys
1905                1910                1915                1920
Arg His Gly Ser Thr Ala Glu Gly Pro Leu Gly His Arg Gly Trp Gly
                1925                1930                1935    
Leu Pro Lys Ala Gln Ser Gly Ser Val Leu Ser Val His Ser Gln Pro
            1940                1945                1950        
Ala Asp Thr Ser Tyr Ile Leu Gln Leu Pro Lys Asp Ala Pro His Leu
        1955                1960                1965            
Leu Gln Pro His Ser Ala Pro Thr Trp Gly Thr Ile Pro Lys Leu Pro
    1970                1975                1980                
Pro Pro Gly Arg Ser Pro Leu Ala Gln Arg Pro Leu Arg Arg Gln Ala
1985                1990                1995                2000
Ala Ile Arg Thr Asp Ser Leu Asp Val Gln Gly Leu Gly Ser Arg Glu
                2005                2010                2015    
Asp Leu Leu Ala Glu Val Ser Gly Pro Ser Pro Pro Leu Ala Arg Ala
            2020                2025                2030        
Tyr Ser Phe Trp Gly Gln Ser Ser Thr Gln Ala Gln Gln His Ser Arg
        2035                2040                2045            
Ser His Ser Lys Ile Ser Lys His Met Thr Pro Pro Ala Pro Cys Pro
    2050                2055                2060                
Gly Pro Glu Pro Asn Trp Gly Lys Gly Pro Pro Glu Thr Arg Ser Ser
2065                2070                2075                2080
Leu Glu Leu Asp Thr Glu Leu Ser Trp Ile Ser Gly Asp Leu Leu Pro
                2085                2090                2095    
Pro Gly Gly Gln Glu Glu Pro Pro Ser Pro Arg Asp Leu Lys Lys Cys
            2100                2105                2110        
Tyr Ser Val Glu Ala Gln Ser Cys Gln Arg Arg Pro Thr Ser Trp Leu
        2115                2120                2125            
Asp Glu Gln Arg Arg His Ser Ile Ala Val Ser Cys Leu Asp Ser Gly
    2130                2135                2140                
Ser Gln Pro His Leu Gly Thr Asp Pro Ser Asn Leu Gly Gly Gln Pro
2145                2150                2155                2160
Leu Gly Gly Pro Gly Ser Arg Pro Lys Lys Lys Leu Ser Pro Pro Ser
                2165                2170                2175    
Ile Thr Ile Asp Pro Pro Glu Ser Gln Gly Pro Arg Thr Pro Pro Ser
            2180                2185                2190        
Pro Gly Ile Cys Leu Arg Arg Arg Ala Pro Ser Ser Asp Ser Lys Asp
        2195                2200                2205            
Pro Leu Ala Ser Gly Pro Pro Asp Ser Met Ala Ala Ser Pro Ser Pro
    2210                2215                2220                
Lys Lys Asp Val Leu Ser Leu Ser Gly Leu Ser Ser Asp Pro Ala Asp
2225                2230                2235                2240
Leu Asp Pro
            


<210> 626
<211> 323
<212> PRT
<213> Homo sapiens

<400> 626
Met Ala Ser Ile Trp Val Gly His Arg Gly Thr Val Arg Asp Tyr Pro
 1               5                  10                  15      
Asp Phe Ser Pro Ser Val Asp Ala Glu Ala Ile Gln Lys Ala Ile Arg
            20                  25                  30          
Gly Ile Gly Thr Asp Glu Lys Met Leu Ile Ser Ile Leu Thr Glu Arg
        35                  40                  45              
Ser Asn Ala Gln Arg Gln Leu Ile Val Lys Glu Tyr Gln Ala Ala Tyr
    50                  55                  60                  
Gly Lys Glu Leu Lys Asp Asp Leu Lys Gly Asp Leu Ser Gly His Phe
65                  70                  75                  80  
Glu His Leu Met Val Ala Leu Val Thr Pro Pro Ala Val Phe Asp Ala
                85                  90                  95      
Lys Gln Leu Lys Lys Ser Met Lys Gly Ala Gly Thr Asn Glu Asp Ala
            100                 105                 110         
Leu Ile Glu Ile Leu Thr Thr Arg Thr Ser Arg Gln Met Lys Asp Ile
        115                 120                 125             
Ser Gln Ala Tyr Tyr Thr Val Tyr Lys Lys Ser Leu Gly Asp Asp Ile
    130                 135                 140                 
Ser Ser Glu Thr Ser Gly Asp Phe Arg Lys Ala Leu Leu Thr Leu Ala
145                 150                 155                 160 
Asp Gly Arg Arg Asp Glu Ser Leu Lys Val Asp Glu His Leu Ala Lys
                165                 170                 175     
Gln Asp Ala Gln Ile Leu Tyr Lys Ala Gly Glu Asn Arg Trp Gly Thr
            180                 185                 190         
Asp Glu Asp Lys Phe Thr Glu Ile Leu Cys Leu Arg Ser Phe Pro Gln
        195                 200                 205             
Leu Lys Leu Thr Phe Asp Glu Tyr Arg Asn Ile Ser Gln Lys Asp Ile
    210                 215                 220                 
Val Asp Ser Ile Lys Gly Glu Leu Ser Gly His Phe Glu Asp Leu Leu
225                 230                 235                 240 
Leu Ala Ile Val Asn Cys Val Arg Asn Thr Pro Ala Phe Leu Ala Glu
                245                 250                 255     
Arg Leu His Arg Ala Leu Lys Gly Ile Gly Thr Asp Glu Phe Thr Leu
            260                 265                 270         
Asn Arg Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asp Ile Arg
        275                 280                 285             
Thr Glu Phe Lys Lys His Tyr Gly Tyr Ser Leu Tyr Ser Ala Ile Lys
    290                 295                 300                 
Ser Asp Thr Ser Gly Asp Tyr Glu Ile Thr Leu Leu Lys Ile Cys Gly
305                 310                 315                 320 
Gly Asp Asp
            


<210> 627
<211> 166
<212> PRT
<213> Homo sapiens

<400> 627
Met Ala Ala Thr Met Phe Arg Ala Thr Leu Arg Gly Trp Arg Thr Gly
 1               5                  10                  15      
Val Gln Arg Gly Cys Gly Leu Arg Leu Leu Ser Gln Thr Gln Gly Pro
            20                  25                  30          
Pro Asp Tyr Pro Arg Phe Val Glu Ser Val Asp Glu Tyr Gln Phe Val
        35                  40                  45              
Glu Arg Leu Leu Pro Ala Thr Arg Ile Pro Asp Pro Pro Lys His Glu
    50                  55                  60                  
His Tyr Pro Thr Pro Ser Gly Trp Gln Pro Pro Arg Asp Pro Pro Pro
65                  70                  75                  80  
Asn Leu Pro Tyr Phe Val Arg Arg Ser Arg Met His Asn Ile Pro Val
                85                  90                  95      
Tyr Lys Asp Ile Thr His Gly Asn Arg Gln Met Thr Val Ile Arg Lys
            100                 105                 110         
Val Glu Gly Asp Ile Trp Ala Leu Gln Lys Asp Val Glu Asp Phe Leu
        115                 120                 125             
Ser Pro Leu Leu Gly Lys Thr Pro Val Thr Gln Val Asn Glu Val Thr
    130                 135                 140                 
Gly Thr Leu Arg Ile Lys Gly Tyr Phe Asp Gln Glu Leu Lys Ala Trp
145                 150                 155                 160 
Leu Leu Glu Lys Gly Phe
                165     


<210> 628
<211> 166
<212> PRT
<213> Homo sapiens

<400> 628
Met Ala Ala Thr Met Phe Arg Ala Thr Leu Arg Gly Trp Arg Thr Gly
 1               5                  10                  15      
Val Gln Arg Gly Cys Gly Leu Arg Leu Leu Ser Gln Thr Gln Gly Pro
            20                  25                  30          
Pro Asp Tyr Pro Arg Phe Val Glu Ser Val Asp Glu Tyr Gln Phe Val
        35                  40                  45              
Glu Arg Leu Leu Pro Ala Thr Arg Ile Pro Asp Pro Pro Lys His Glu
    50                  55                  60                  
His Tyr Pro Thr Pro Ser Gly Trp Gln Pro Pro Arg Asp Pro Pro Pro
65                  70                  75                  80  
Asn Leu Pro Tyr Phe Val Arg Arg Ser Arg Met His Asn Ile Pro Val
                85                  90                  95      
Tyr Lys Asp Ile Thr His Gly Asn Arg Gln Met Thr Val Ile Arg Lys
            100                 105                 110         
Val Glu Gly Asp Ile Trp Ala Leu Gln Lys Asp Val Glu Asp Phe Leu
        115                 120                 125             
Ser Pro Leu Leu Gly Lys Thr Pro Val Thr Gln Val Asn Glu Val Thr
    130                 135                 140                 
Gly Thr Leu Arg Ile Lys Gly Tyr Phe Asp Gln Glu Leu Lys Ala Trp
145                 150                 155                 160 
Leu Leu Glu Lys Gly Phe
                165     


<210> 629
<211> 261
<212> PRT
<213> Homo sapiens

<400> 629
Met Ala Glu Ser His Leu Gln Ser Ser Leu Ile Thr Ala Ser Gln Phe
 1               5                  10                  15      
Phe Glu Ile Trp Leu His Phe Asp Ala Asp Gly Ser Gly Tyr Leu Glu
            20                  25                  30          
Gly Lys Glu Leu Gln Asn Leu Ile Gln Glu Leu Gln Gln Ala Arg Lys
        35                  40                  45              
Lys Ala Gly Leu Glu Leu Ser Pro Glu Met Lys Thr Phe Val Asp Gln
    50                  55                  60                  
Tyr Gly Gln Arg Asp Asp Gly Lys Ile Gly Ile Val Glu Leu Ala His
65                  70                  75                  80  
Val Leu Pro Thr Glu Glu Asn Phe Leu Leu Leu Phe Arg Cys Gln Gln
                85                  90                  95      
Leu Lys Ser Cys Glu Glu Phe Met Lys Thr Trp Arg Lys Tyr Asp Thr
            100                 105                 110         
Asp His Ser Gly Phe Ile Glu Thr Glu Glu Leu Lys Asn Phe Leu Lys
        115                 120                 125             
Asp Leu Leu Glu Lys Ala Asn Lys Thr Val Asp Asp Thr Lys Leu Ala
    130                 135                 140                 
Glu Tyr Thr Asp Leu Met Leu Lys Leu Phe Asp Ser Asn Asn Asp Gly
145                 150                 155                 160 
Lys Leu Glu Leu Thr Glu Met Ala Arg Leu Leu Pro Val Gln Glu Asn
                165                 170                 175     
Phe Leu Leu Lys Phe Gln Gly Ile Lys Met Cys Gly Lys Glu Phe Asn
            180                 185                 190         
Lys Ala Phe Glu Leu Tyr Asp Gln Asp Gly Asn Gly Tyr Ile Asp Glu
        195                 200                 205             
Asn Glu Leu Asp Ala Leu Leu Lys Asp Leu Cys Glu Lys Asn Lys Gln
    210                 215                 220                 
Asp Leu Asp Ile Asn Asn Ile Thr Thr Tyr Lys Lys Asn Ile Met Ala
225                 230                 235                 240 
Leu Ser Asp Gly Gly Lys Leu Tyr Arg Thr Asp Leu Ala Leu Ile Leu
                245                 250                 255     
Cys Ala Gly Asp Asn
            260     


<210> 630
<211> 348
<212> PRT
<213> Homo sapiens

<400> 630
Met Ala Ser Arg Glu Asp Glu Leu Arg Asn Cys Val Val Cys Gly Asp
 1               5                  10                  15      
Gln Ala Thr Gly Tyr His Phe Asn Ala Leu Thr Cys Glu Gly Cys Lys
            20                  25                  30          
Gly Phe Phe Arg Arg Thr Val Ser Lys Ser Ile Gly Pro Thr Cys Pro
        35                  40                  45              
Phe Ala Gly Ser Cys Glu Val Ser Lys Thr Gln Arg Arg His Cys Pro
    50                  55                  60                  
Ala Cys Arg Leu Gln Lys Cys Leu Asp Ala Gly Met Arg Lys Asp Met
65                  70                  75                  80  
Ile Leu Ser Ala Glu Ala Leu Ala Leu Arg Arg Ala Lys Gln Ala Gln
                85                  90                  95      
Arg Arg Ala Gln Gln Thr Pro Val Gln Leu Ser Lys Glu Gln Glu Glu
            100                 105                 110         
Leu Ile Arg Thr Leu Leu Gly Ala His Thr Arg His Met Gly Thr Met
        115                 120                 125             
Phe Glu Gln Phe Val Gln Phe Arg Pro Pro Ala His Leu Phe Ile His
    130                 135                 140                 
His Gln Pro Leu Pro Thr Leu Ala Pro Val Leu Pro Leu Val Thr His
145                 150                 155                 160 
Phe Ala Asp Ile Asn Thr Phe Met Val Leu Gln Val Ile Lys Phe Thr
                165                 170                 175     
Lys Asp Leu Pro Val Phe Arg Ser Leu Pro Ile Glu Asp Gln Ile Ser
            180                 185                 190         
Leu Leu Lys Gly Ala Ala Val Glu Ile Cys His Ile Val Leu Asn Thr
        195                 200                 205             
Thr Phe Cys Leu Gln Thr Gln Asn Phe Leu Cys Gly Pro Leu Arg Tyr
    210                 215                 220                 
Thr Ile Glu Asp Gly Ala Arg Val Gly Phe Gln Val Glu Phe Leu Glu
225                 230                 235                 240 
Leu Leu Phe His Phe His Gly Thr Leu Arg Lys Leu Gln Leu Gln Glu
                245                 250                 255     
Pro Glu Tyr Val Leu Leu Ala Ala Met Ala Leu Phe Ser Pro Asp Arg
            260                 265                 270         
Pro Gly Val Thr Gln Arg Asp Glu Ile Asp Gln Leu Gln Glu Glu Met
        275                 280                 285             
Ala Leu Thr Leu Gln Ser Tyr Ile Lys Gly Gln Gln Arg Arg Pro Arg
    290                 295                 300                 
Asp Arg Phe Leu Tyr Ala Lys Leu Leu Gly Leu Leu Ala Glu Leu Arg
305                 310                 315                 320 
Ser Ile Asn Glu Ala Tyr Gly Tyr Gln Ile Gln His Ile Gln Gly Leu
                325                 330                 335     
Ser Ala Met Met Pro Leu Leu Gln Glu Ile Cys Ser
            340                 345             


<210> 631
<211> 348
<212> PRT
<213> Homo sapiens

<400> 631
Met Ala Ser Arg Glu Asp Glu Leu Arg Asn Cys Val Val Cys Gly Asp
 1               5                  10                  15      
Gln Ala Thr Gly Tyr His Phe Asn Ala Leu Thr Cys Glu Gly Cys Lys
            20                  25                  30          
Gly Phe Phe Arg Arg Thr Val Ser Lys Ser Ile Gly Pro Thr Cys Pro
        35                  40                  45              
Phe Ala Gly Ser Cys Glu Val Ser Lys Thr Gln Arg Arg His Cys Pro
    50                  55                  60                  
Ala Cys Arg Leu Gln Lys Cys Leu Asp Ala Gly Met Arg Lys Asp Met
65                  70                  75                  80  
Ile Leu Ser Ala Glu Ala Leu Ala Leu Arg Arg Ala Lys Gln Ala Gln
                85                  90                  95      
Arg Arg Ala Gln Gln Thr Pro Val Gln Leu Ser Lys Glu Gln Glu Glu
            100                 105                 110         
Leu Ile Arg Thr Leu Leu Gly Ala His Thr Arg His Met Gly Thr Met
        115                 120                 125             
Phe Glu Gln Phe Val Gln Phe Arg Pro Pro Ala His Leu Phe Ile His
    130                 135                 140                 
His Gln Pro Leu Pro Thr Leu Ala Pro Val Leu Pro Leu Val Thr His
145                 150                 155                 160 
Phe Ala Asp Ile Asn Thr Phe Met Val Leu Gln Val Ile Lys Phe Thr
                165                 170                 175     
Lys Asp Leu Pro Val Phe Arg Ser Leu Pro Ile Glu Asp Gln Ile Ser
            180                 185                 190         
Leu Leu Lys Gly Ala Ala Val Glu Ile Cys His Ile Val Leu Asn Thr
        195                 200                 205             
Thr Phe Cys Leu Gln Thr Gln Asn Phe Leu Cys Gly Pro Leu Arg Tyr
    210                 215                 220                 
Thr Ile Glu Asp Gly Ala Arg Val Gly Phe Gln Val Glu Phe Leu Glu
225                 230                 235                 240 
Leu Leu Phe His Phe His Gly Thr Leu Arg Lys Leu Gln Leu Gln Glu
                245                 250                 255     
Pro Glu Tyr Val Leu Leu Ala Ala Met Ala Leu Phe Ser Pro Asp Arg
            260                 265                 270         
Pro Gly Val Thr Gln Arg Asp Glu Ile Asp Gln Leu Gln Glu Glu Met
        275                 280                 285             
Ala Leu Thr Leu Gln Ser Tyr Ile Lys Gly Gln Gln Arg Arg Pro Arg
    290                 295                 300                 
Asp Arg Phe Leu Tyr Ala Lys Leu Leu Gly Leu Leu Ala Glu Leu Arg
305                 310                 315                 320 
Ser Ile Asn Glu Ala Tyr Gly Tyr Gln Ile Gln His Ile Gln Gly Leu
                325                 330                 335     
Ser Ala Met Met Pro Leu Leu Gln Glu Ile Cys Ser
            340                 345             


<210> 632
<211> 605
<212> PRT
<213> Homo sapiens

<400> 632
Met Ala Leu Arg Lys Gly Gly Leu Ala Leu Ala Leu Leu Leu Leu Ser
 1               5                  10                  15      
Trp Val Ala Leu Gly Pro Arg Ser Leu Glu Gly Ala Asp Pro Gly Thr
            20                  25                  30          
Pro Gly Glu Ala Glu Gly Pro Ala Cys Pro Ala Ala Cys Val Cys Ser
        35                  40                  45              
Tyr Asp Asp Asp Ala Asp Glu Leu Ser Val Phe Cys Ser Ser Arg Asn
    50                  55                  60                  
Leu Thr Arg Leu Pro Asp Gly Val Pro Gly Gly Thr Gln Ala Leu Trp
65                  70                  75                  80  
Leu Asp Gly Asn Asn Leu Ser Ser Val Pro Pro Ala Ala Phe Gln Asn
                85                  90                  95      
Leu Ser Ser Leu Gly Phe Leu Asn Leu Gln Gly Gly Gln Leu Gly Ser
            100                 105                 110         
Leu Glu Pro Gln Ala Leu Leu Gly Leu Glu Asn Leu Cys His Leu His
        115                 120                 125             
Leu Glu Arg Asn Gln Leu Arg Ser Leu Ala Leu Gly Thr Phe Ala His
    130                 135                 140                 
Thr Pro Ala Leu Ala Ser Leu Gly Leu Ser Asn Asn Arg Leu Ser Arg
145                 150                 155                 160 
Leu Glu Asp Gly Leu Phe Glu Gly Leu Gly Ser Leu Trp Asp Leu Asn
                165                 170                 175     
Leu Gly Trp Asn Ser Leu Ala Val Leu Pro Asp Ala Ala Phe Arg Gly
            180                 185                 190         
Leu Gly Ser Leu Arg Glu Leu Val Leu Ala Gly Asn Arg Leu Ala Tyr
        195                 200                 205             
Leu Gln Pro Ala Leu Phe Ser Gly Leu Ala Glu Leu Arg Glu Leu Asp
    210                 215                 220                 
Leu Ser Arg Asn Ala Leu Arg Ala Ile Lys Ala Asn Val Phe Val Gln
225                 230                 235                 240 
Leu Pro Arg Leu Gln Lys Leu Tyr Leu Asp Arg Asn Leu Ile Ala Ala
                245                 250                 255     
Val Ala Pro Gly Ala Phe Leu Gly Leu Lys Ala Leu Arg Trp Leu Asp
            260                 265                 270         
Leu Ser His Asn Arg Val Ala Gly Leu Leu Glu Asp Thr Phe Pro Gly
        275                 280                 285             
Leu Leu Gly Leu Arg Val Leu Arg Leu Ser His Asn Ala Ile Ala Ser
    290                 295                 300                 
Leu Arg Pro Arg Thr Phe Lys Asp Leu His Phe Leu Glu Glu Leu Gln
305                 310                 315                 320 
Leu Gly His Asn Arg Ile Arg Gln Leu Ala Glu Arg Ser Phe Glu Gly
                325                 330                 335     
Leu Gly Gln Leu Glu Val Leu Thr Leu Asp His Asn Gln Leu Gln Glu
            340                 345                 350         
Val Lys Ala Gly Ala Phe Leu Gly Leu Thr Asn Val Ala Val Met Asn
        355                 360                 365             
Leu Ser Gly Asn Cys Leu Arg Asn Leu Pro Glu Gln Val Phe Arg Gly
    370                 375                 380                 
Leu Gly Lys Leu His Ser Leu His Leu Glu Gly Ser Cys Leu Gly Arg
385                 390                 395                 400 
Ile Arg Pro His Thr Phe Thr Gly Leu Ser Gly Leu Arg Arg Leu Phe
                405                 410                 415     
Leu Lys Asp Asn Gly Leu Val Gly Ile Glu Glu Gln Ser Leu Trp Gly
            420                 425                 430         
Leu Ala Glu Leu Leu Glu Leu Asp Leu Thr Ser Asn Gln Leu Thr His
        435                 440                 445             
Leu Pro His Arg Leu Phe Gln Gly Leu Gly Lys Leu Glu Tyr Leu Leu
    450                 455                 460                 
Leu Ser Arg Asn Arg Leu Ala Glu Leu Pro Ala Asp Ala Leu Gly Pro
465                 470                 475                 480 
Leu Gln Arg Ala Phe Trp Leu Asp Val Ser His Asn Arg Leu Glu Ala
                485                 490                 495     
Leu Pro Asn Ser Leu Leu Ala Pro Leu Gly Arg Leu Arg Tyr Leu Ser
            500                 505                 510         
Leu Arg Asn Asn Ser Leu Arg Thr Phe Thr Pro Gln Pro Pro Gly Leu
        515                 520                 525             
Glu Arg Leu Trp Leu Glu Gly Asn Pro Trp Asp Cys Gly Cys Pro Leu
    530                 535                 540                 
Lys Ala Leu Arg Asp Phe Ala Leu Gln Asn Pro Ser Ala Val Pro Arg
545                 550                 555                 560 
Phe Val Gln Ala Ile Cys Glu Gly Asp Asp Cys Gln Pro Pro Ala Tyr
                565                 570                 575     
Thr Tyr Asn Asn Ile Thr Cys Ala Ser Pro Pro Glu Val Val Gly Leu
            580                 585                 590         
Asp Leu Arg Asp Leu Ser Glu Ala His Phe Ala Pro Cys
        595                 600                 605 


<210> 633
<211> 116
<212> PRT
<213> Homo sapiens

<400> 633
Met Ala Gly Val Leu Lys Lys Thr Thr Gly Leu Val Gly Leu Ala Val
 1               5                  10                  15      
Cys Asn Thr Pro His Glu Arg Leu Arg Ile Leu Tyr Thr Lys Ile Leu
            20                  25                  30          
Asp Val Leu Glu Glu Ile Pro Lys Asn Ala Ala Tyr Arg Lys Tyr Thr
        35                  40                  45              
Glu Gln Ile Thr Asn Glu Lys Leu Ala Met Val Lys Ala Glu Pro Asp
    50                  55                  60                  
Val Lys Lys Leu Glu Asp Gln Leu Gln Gly Gly Gln Leu Glu Glu Val
65                  70                  75                  80  
Ile Leu Gln Ala Glu His Glu Leu Asn Leu Ala Arg Lys Met Arg Glu
                85                  90                  95      
Trp Lys Leu Trp Glu Pro Leu Val Glu Glu Pro Pro Ala Asp Gln Trp
            100                 105                 110         
Lys Trp Pro Ile
        115     


<210> 634
<211> 118
<212> PRT
<213> Homo sapiens

<400> 634
Met Arg Gly Arg Lys Met Ala Ser Ala Thr Arg Leu Ile Gln Arg Leu
 1               5                  10                  15      
Arg Asn Trp Ala Ser Gly His Asp Leu Gln Gly Lys Leu Gln Leu Arg
            20                  25                  30          
Tyr Gln Glu Ile Ser Lys Arg Thr Gln Pro Pro Pro Lys Leu Pro Val
        35                  40                  45              
Gly Pro Ser His Lys Leu Ser Asn Asn Tyr Tyr Cys Thr Arg Asp Gly
    50                  55                  60                  
Arg Arg Glu Ser Val Pro Pro Ser Ile Ile Met Ser Ser Gln Lys Ala
65                  70                  75                  80  
Leu Val Ser Gly Lys Pro Ala Glu Ser Ser Ala Val Ala Ala Thr Glu
                85                  90                  95      
Lys Lys Ala Val Thr Pro Ala Pro Pro Ile Lys Arg Trp Glu Leu Ser
            100                 105                 110         
Ser Asp Gln Pro Tyr Leu
        115             


<210> 635
<211> 156
<212> PRT
<213> Homo sapiens

<400> 635
Met Ala Ser Arg Val Leu Ser Ala Tyr Val Ser Arg Leu Pro Ala Ala
 1               5                  10                  15      
Phe Ala Pro Leu Pro Arg Val Arg Met Leu Ala Val Ala Arg Pro Leu
            20                  25                  30          
Ser Thr Ala Leu Cys Ser Ala Gly Thr Gln Thr Arg Leu Gly Thr Leu
        35                  40                  45              
Gln Pro Ala Leu Val Leu Ala Gln Val Pro Gly Arg Val Thr Gln Leu
    50                  55                  60                  
Cys Arg Gln Tyr Ser Asp Met Pro Pro Leu Thr Leu Glu Gly Ile Gln
65                  70                  75                  80  
Asp Arg Val Leu Tyr Val Leu Lys Leu Tyr Asp Lys Ile Asp Pro Glu
                85                  90                  95      
Lys Leu Ser Val Asn Ser His Phe Met Lys Asp Leu Gly Leu Asp Ser
            100                 105                 110         
Leu Asp Gln Val Glu Ile Ile Met Ala Met Glu Asp Glu Phe Gly Phe
        115                 120                 125             
Glu Ile Pro Asp Ile Asp Ala Glu Lys Leu Met Cys Pro Gln Glu Ile
    130                 135                 140                 
Val Asp Tyr Ile Ala Asp Lys Lys Asp Val Tyr Glu
145                 150                 155     


<210> 636
<211> 727
<212> PRT
<213> Homo sapiens

<400> 636
Met Leu Arg Ile Pro Val Arg Arg Ala Leu Val Gly Leu Ser Lys Ser
 1               5                  10                  15      
Pro Lys Gly Cys Val Arg Thr Thr Ala Thr Ala Ala Ser Asn Leu Ile
            20                  25                  30          
Glu Val Phe Val Asp Gly Gln Ser Val Met Val Glu Pro Gly Thr Thr
        35                  40                  45              
Val Leu Gln Ala Cys Glu Lys Val Gly Met Gln Ile Pro Arg Phe Cys
    50                  55                  60                  
Tyr His Glu Arg Leu Ser Val Ala Gly Asn Cys Arg Met Cys Leu Val
65                  70                  75                  80  
Glu Ile Glu Lys Ala Pro Lys Val Val Ala Ala Cys Ala Met Pro Val
                85                  90                  95      
Met Lys Gly Trp Asn Ile Leu Thr Asn Ser Glu Lys Ser Lys Lys Ala
            100                 105                 110         
Arg Glu Gly Val Met Glu Phe Leu Leu Ala Asn His Pro Leu Asp Cys
        115                 120                 125             
Pro Ile Cys Asp Gln Gly Gly Glu Cys Asp Leu Gln Asp Gln Ser Met
    130                 135                 140                 
Met Phe Gly Asn Asp Arg Ser Arg Phe Leu Glu Gly Lys Arg Ala Val
145                 150                 155                 160 
Glu Asp Lys Asn Ile Gly Pro Leu Val Lys Thr Ile Met Thr Arg Cys
                165                 170                 175     
Ile Gln Cys Thr Arg Cys Ile Arg Phe Ala Ser Glu Ile Ala Gly Val
            180                 185                 190         
Asp Asp Leu Gly Thr Thr Gly Arg Gly Asn Asp Met Gln Val Gly Thr
        195                 200                 205             
Tyr Ile Glu Lys Met Phe Met Ser Glu Leu Ser Gly Asn Ile Ile Asp
    210                 215                 220                 
Ile Cys Pro Val Gly Ala Leu Thr Ser Lys Pro Tyr Ala Phe Thr Ala
225                 230                 235                 240 
Arg Pro Trp Glu Thr Arg Lys Thr Glu Ser Ile Asp Val Met Asp Ala
                245                 250                 255     
Val Gly Ser Asn Ile Val Val Ser Thr Arg Thr Gly Glu Val Met Arg
            260                 265                 270         
Ile Leu Pro Arg Met His Glu Asp Ile Asn Glu Glu Trp Ile Ser Asp
        275                 280                 285             
Lys Thr Arg Phe Ala Tyr Asp Gly Leu Lys Arg Gln Arg Leu Thr Glu
    290                 295                 300                 
Pro Met Val Arg Asn Glu Lys Gly Leu Leu Thr Tyr Thr Ser Trp Glu
305                 310                 315                 320 
Asp Ala Leu Ser Arg Val Ala Gly Met Leu Gln Ser Phe Gln Gly Lys
                325                 330                 335     
Asp Val Ala Ala Ile Ala Gly Gly Leu Val Asp Ala Glu Ala Leu Val
            340                 345                 350         
Ala Leu Lys Asp Leu Leu Asn Arg Val Asp Ser Asp Thr Leu Cys Thr
        355                 360                 365             
Glu Glu Val Phe Pro Thr Ala Gly Ala Gly Thr Asp Leu Arg Ser Asn
    370                 375                 380                 
Tyr Leu Leu Asn Thr Thr Ile Ala Gly Val Glu Glu Ala Asp Val Val
385                 390                 395                 400 
Leu Leu Val Gly Thr Asn Pro Arg Phe Glu Ala Pro Leu Phe Asn Ala
                405                 410                 415     
Trp Ile Arg Lys Ser Trp Leu His Asn Asp Leu Lys Val Ala Leu Ile
            420                 425                 430         
Gly Ser Pro Val Asp Leu Thr Tyr Thr Tyr Asp His Leu Gly Asp Ser
        435                 440                 445             
Pro Lys Ile Leu Gln Asp Ile Ala Ser Gly Ser His Pro Phe Ser Gln
    450                 455                 460                 
Val Leu Lys Glu Ala Lys Lys Pro Met Val Val Leu Gly Ser Ser Ala
465                 470                 475                 480 
Leu Gln Arg Asn Asp Gly Ala Ala Ile Leu Ala Ala Val Ser Ser Ile
                485                 490                 495     
Ala Gln Lys Ile Arg Met Thr Ser Gly Val Thr Gly Asp Trp Lys Val
            500                 505                 510         
Met Asn Ile Leu His Arg Ile Ala Ser Gln Val Ala Ala Leu Asp Leu
        515                 520                 525             
Gly Tyr Lys Pro Gly Val Glu Ala Ile Arg Lys Asn Pro Pro Lys Val
    530                 535                 540                 
Leu Phe Leu Leu Gly Ala Asp Gly Gly Cys Ile Thr Arg Gln Asp Leu
545                 550                 555                 560 
Pro Lys Asp Cys Phe Ile Ile Tyr Gln Gly His His Gly Asp Val Gly
                565                 570                 575     
Ala Pro Ile Ala Asp Val Ile Leu Pro Gly Ala Ala Tyr Thr Glu Lys
            580                 585                 590         
Ser Ala Thr Tyr Val Asn Thr Glu Gly Arg Ala Gln Gln Thr Lys Val
        595                 600                 605             
Ala Val Thr Pro Pro Gly Leu Ala Arg Glu Asp Trp Lys Ile Ile Arg
    610                 615                 620                 
Ala Leu Ser Glu Ile Ala Gly Met Thr Leu Pro Tyr Asp Thr Leu Asp
625                 630                 635                 640 
Gln Val Arg Asn Arg Leu Glu Glu Phe Ser Pro Asn Leu Val Arg Tyr
                645                 650                 655     
Asp Asp Ile Glu Gly Ala Asn Tyr Phe Gln Gln Ala Asn Glu Leu Ser
            660                 665                 670         
Lys Leu Val Asn Gln Gln Leu Leu Ala Asp Pro Leu Val Pro Pro Gln
        675                 680                 685             
Leu Thr Leu Lys Asp Phe Tyr Met Thr Asp Ser Ile Ser Arg Ala Ser
    690                 695                 700                 
Gln Thr Met Ala Lys Cys Val Lys Ala Val Thr Glu Gly Ala Gln Ala
705                 710                 715                 720 
Val Glu Glu Pro Ser Ile Cys
                725         


<210> 637
<211> 140
<212> PRT
<213> Homo sapiens

<400> 637
Met Ala Gly Trp Asn Ala Tyr Ile Asp Asn Leu Met Ala Asp Gly Thr
 1               5                  10                  15      
Cys Gln Asp Ala Ala Ile Val Gly Tyr Lys Asp Ser Pro Ser Val Trp
            20                  25                  30          
Ala Ala Val Pro Gly Lys Thr Phe Val Asn Ile Thr Pro Ala Glu Val
        35                  40                  45              
Gly Val Leu Val Gly Lys Asp Arg Ser Ser Phe Tyr Val Asn Gly Leu
    50                  55                  60                  
Thr Leu Gly Gly Gln Lys Cys Ser Val Ile Arg Asp Ser Leu Leu Gln
65                  70                  75                  80  
Asp Gly Glu Phe Ser Met Asp Leu Arg Thr Lys Ser Thr Gly Gly Ala
                85                  90                  95      
Pro Thr Phe Asn Val Thr Val Thr Lys Thr Asp Lys Thr Leu Val Leu
            100                 105                 110         
Leu Met Gly Lys Glu Gly Val His Gly Gly Leu Ile Asn Lys Lys Cys
        115                 120                 125             
Tyr Glu Met Ala Ser His Leu Arg Arg Ser Gln Tyr
    130                 135                 140 


<210> 638
<211> 1012
<212> PRT
<213> Homo sapiens

<400> 638
Met Ala Glu Ala Ala Leu Glu Ala Val Arg Ser Glu Leu Arg Glu Phe
 1               5                  10                  15      
Pro Ala Ala Ala Arg Glu Leu Cys Val Pro Leu Ala Val Pro Tyr Leu
            20                  25                  30          
Asp Lys Pro Pro Thr Pro Leu His Phe Tyr Arg Asp Trp Val Cys Pro
        35                  40                  45              
Asn Arg Pro Cys Ile Ile Arg Asn Ala Leu Gln His Trp Pro Ala Leu
    50                  55                  60                  
Gln Lys Trp Ser Leu Pro Tyr Phe Arg Ala Thr Val Gly Ser Thr Glu
65                  70                  75                  80  
Val Ser Val Ala Val Thr Pro Asp Gly Tyr Ala Asp Ala Val Arg Gly
                85                  90                  95      
Asp Arg Phe Met Met Pro Ala Glu Arg Arg Leu Pro Leu Ser Phe Val
            100                 105                 110         
Leu Asp Val Leu Glu Gly Arg Ala Gln His Pro Gly Val Leu Tyr Val
        115                 120                 125             
Gln Lys Gln Cys Ser Asn Leu Pro Ser Glu Leu Pro Gln Leu Leu Pro
    130                 135                 140                 
Asp Leu Glu Ser His Val Pro Trp Ala Ser Glu Ala Leu Gly Lys Met
145                 150                 155                 160 
Pro Asp Ala Val Asn Phe Trp Leu Gly Glu Ala Ala Ala Val Thr Ser
                165                 170                 175     
Leu His Lys Asp His Tyr Glu Asn Leu Tyr Cys Val Val Ser Gly Glu
            180                 185                 190         
Lys His Phe Leu Phe His Pro Pro Ser Asp Arg Pro Phe Ile Pro Tyr
        195                 200                 205             
Glu Leu Tyr Thr Pro Ala Thr Tyr Gln Leu Thr Glu Glu Gly Thr Phe
    210                 215                 220                 
Lys Val Val Asp Glu Glu Ala Met Glu Lys Ala Glu Val Ser Arg Thr
225                 230                 235                 240 
Cys Leu Leu Thr Val Arg Val Leu Gln Ala His Arg Leu Pro Ser Lys
                245                 250                 255     
Asp Leu Val Thr Pro Ser Asp Cys Tyr Val Thr Leu Trp Leu Pro Thr
            260                 265                 270         
Ala Cys Ser His Arg Leu Gln Thr Arg Thr Val Lys Asn Ser Ser Ser
        275                 280                 285             
Pro Val Trp Asn Gln Ser Phe His Phe Arg Ile His Arg Gln Leu Lys
    290                 295                 300                 
Asn Val Met Glu Leu Lys Val Phe Asp Gln Asp Leu Val Thr Gly Asp
305                 310                 315                 320 
Asp Pro Val Leu Ser Val Leu Phe Asp Ala Gly Thr Leu Arg Ala Gly
                325                 330                 335     
Glu Phe Arg Arg Glu Ser Phe Ser Leu Ser Pro Gln Gly Glu Gly Arg
            340                 345                 350         
Leu Glu Val Glu Phe Arg Leu Gln Ser Leu Ala Asp Arg Gly Glu Trp
        355                 360                 365             
Leu Val Ser Asn Gly Val Leu Val Ala Arg Glu Leu Ser Cys Leu His
    370                 375                 380                 
Val Gln Leu Glu Glu Thr Gly Asp Gln Lys Ser Ser Glu His Arg Val
385                 390                 395                 400 
Gln Leu Val Val Pro Gly Ser Cys Glu Gly Pro Gln Glu Ala Ser Val
                405                 410                 415     
Gly Thr Gly Thr Phe Arg Phe His Cys Pro Ala Cys Trp Glu Gln Glu
            420                 425                 430         
Leu Ser Ile Arg Leu Gln Asp Ala Pro Glu Glu Gln Leu Lys Ala Pro
        435                 440                 445             
Leu Ser Ala Leu Pro Ser Gly Gln Val Val Arg Leu Val Phe Pro Thr
    450                 455                 460                 
Ser Gln Glu Pro Leu Met Arg Val Glu Leu Lys Lys Glu Ala Gly Leu
465                 470                 475                 480 
Arg Glu Leu Ala Val Arg Leu Gly Phe Gly Pro Cys Ala Glu Glu Gln
                485                 490                 495     
Ala Phe Leu Ser Arg Arg Lys Gln Val Val Ala Ala Ala Leu Arg Gln
            500                 505                 510         
Ala Leu Gln Leu Asp Gly Asp Leu Gln Glu Asp Glu Ile Pro Val Val
        515                 520                 525             
Ala Ile Met Ala Thr Gly Gly Gly Ile Arg Ala Met Thr Ser Leu Tyr
    530                 535                 540                 
Gly Gln Leu Ala Gly Leu Lys Glu Leu Gly Leu Leu Asp Cys Val Ser
545                 550                 555                 560 
Tyr Ile Thr Gly Ala Ser Gly Ser Thr Trp Ala Leu Ala Asn Leu Tyr
                565                 570                 575     
Glu Asp Pro Glu Trp Ser Gln Lys Asp Leu Ala Gly Pro Thr Glu Leu
            580                 585                 590         
Leu Lys Thr Gln Val Thr Lys Asn Lys Leu Gly Val Leu Ala Pro Ser
        595                 600                 605             
Gln Leu Gln Arg Tyr Arg Gln Glu Leu Ala Glu Arg Ala Arg Leu Gly
    610                 615                 620                 
Tyr Pro Ser Cys Phe Thr Asn Leu Trp Ala Leu Ile Asn Glu Ala Leu
625                 630                 635                 640 
Leu His Asp Glu Pro His Asp His Lys Leu Ser Asp Gln Arg Glu Ala
                645                 650                 655     
Leu Ser His Gly Gln Asn Pro Leu Pro Ile Tyr Cys Ala Leu Asn Thr
            660                 665                 670         
Lys Gly Gln Ser Leu Thr Thr Phe Glu Phe Gly Glu Trp Cys Glu Phe
        675                 680                 685             
Ser Pro Tyr Glu Val Gly Phe Pro Lys Tyr Gly Ala Phe Ile Pro Ser
    690                 695                 700                 
Glu Leu Phe Gly Ser Glu Phe Phe Met Gly Gln Leu Met Lys Arg Leu
705                 710                 715                 720 
Pro Glu Ser Arg Ile Cys Phe Leu Glu Gly Ile Trp Ser Asn Leu Tyr
                725                 730                 735     
Ala Ala Asn Leu Gln Asp Ser Leu Tyr Trp Ala Ser Glu Pro Ser Gln
            740                 745                 750         
Phe Trp Asp Arg Trp Val Arg Asn Gln Ala Asn Leu Asp Lys Glu Gln
        755                 760                 765             
Val Pro Leu Leu Lys Ile Glu Glu Pro Pro Ser Thr Ala Gly Arg Ile
    770                 775                 780                 
Ala Glu Phe Phe Thr Asp Leu Leu Thr Trp Arg Pro Leu Ala Gln Ala
785                 790                 795                 800 
Thr His Asn Phe Leu Arg Gly Leu His Phe His Lys Asp Tyr Phe Gln
                805                 810                 815     
His Pro His Phe Ser Thr Trp Lys Ala Thr Thr Leu Asp Gly Leu Pro
            820                 825                 830         
Asn Gln Leu Thr Pro Ser Glu Pro His Leu Cys Leu Leu Asp Val Gly
        835                 840                 845             
Tyr Leu Ile Asn Thr Ser Cys Leu Pro Leu Leu Gln Pro Thr Arg Asp
    850                 855                 860                 
Val Asp Leu Ile Leu Ser Leu Asp Tyr Asn Leu His Gly Ala Phe Gln
865                 870                 875                 880 
Gln Leu Gln Leu Leu Gly Arg Phe Cys Gln Glu Gln Gly Ile Pro Phe
                885                 890                 895     
Pro Pro Ile Ser Pro Ser Pro Glu Glu Gln Leu Gln Pro Arg Glu Cys
            900                 905                 910         
His Thr Phe Ser Asp Pro Thr Cys Pro Gly Ala Pro Ala Val Leu His
        915                 920                 925             
Phe Pro Leu Val Ser Asp Ser Phe Arg Glu Tyr Ser Ala Pro Gly Val
    930                 935                 940                 
Arg Arg Thr Pro Glu Glu Ala Ala Ala Gly Glu Val Asn Leu Ser Ser
945                 950                 955                 960 
Ser Asp Ser Pro Tyr His Tyr Thr Lys Val Thr Tyr Ser Gln Glu Asp
                965                 970                 975     
Val Asp Lys Leu Leu His Leu Thr His Tyr Asn Val Cys Asn Asn Gln
            980                 985                 990         
Glu Gln Leu Leu Glu Ala Leu Arg Gln Ala Val Gln Arg Arg Arg Gln
        995                 1000                1005            
Arg Arg Pro His
    1010        


<210> 639
<211> 253
<212> PRT
<213> Homo sapiens

<400> 639
Met Ala Arg Ser Leu Leu Leu Pro Leu Gln Ile Leu Leu Leu Ser Leu
 1               5                  10                  15      
Ala Leu Glu Thr Ala Gly Glu Glu Ala Gln Gly Asp Lys Ile Ile Asp
            20                  25                  30          
Gly Ala Pro Cys Ala Arg Gly Ser His Pro Trp Gln Val Ala Leu Leu
        35                  40                  45              
Ser Gly Asn Gln Leu His Cys Gly Gly Val Leu Val Asn Glu Arg Trp
    50                  55                  60                  
Val Leu Thr Ala Ala His Cys Lys Met Asn Glu Tyr Thr Val His Leu
65                  70                  75                  80  
Gly Ser Asp Thr Leu Gly Asp Arg Arg Ala Gln Arg Ile Lys Ala Ser
                85                  90                  95      
Lys Ser Phe Arg His Pro Gly Tyr Ser Thr Gln Thr His Val Asn Asp
            100                 105                 110         
Leu Met Leu Val Lys Leu Asn Ser Gln Ala Arg Leu Ser Ser Met Val
        115                 120                 125             
Lys Lys Val Arg Leu Pro Ser Arg Cys Glu Pro Pro Gly Thr Thr Cys
    130                 135                 140                 
Thr Val Ser Gly Trp Gly Thr Thr Thr Ser Pro Asp Val Thr Phe Pro
145                 150                 155                 160 
Ser Asp Leu Met Cys Val Asp Val Lys Leu Ile Ser Pro Gln Asp Cys
                165                 170                 175     
Thr Lys Val Tyr Lys Asp Leu Leu Glu Asn Ser Met Leu Cys Ala Gly
            180                 185                 190         
Ile Pro Asp Ser Lys Lys Asn Ala Cys Asn Gly Asp Ser Gly Gly Pro
        195                 200                 205             
Leu Val Cys Arg Gly Thr Leu Gln Gly Leu Val Ser Trp Gly Thr Phe
    210                 215                 220                 
Pro Cys Gly Gln Pro Asn Asp Pro Gly Val Tyr Thr Gln Val Cys Lys
225                 230                 235                 240 
Phe Thr Lys Trp Ile Asn Asp Thr Met Lys Lys His Arg
                245                 250             


<210> 640
<211> 630
<212> PRT
<213> Homo sapiens

<400> 640
Met Ala Glu Leu Cys Pro Leu Ala Glu Glu Leu Ser Cys Ser Ile Cys
 1               5                  10                  15      
Leu Glu Pro Phe Lys Glu Pro Val Thr Thr Pro Cys Gly His Asn Phe
            20                  25                  30          
Cys Gly Ser Cys Leu Asn Glu Thr Trp Ala Val Gln Gly Ser Pro Tyr
        35                  40                  45              
Leu Cys Pro Gln Cys Arg Ala Val Tyr Gln Ala Arg Pro Gln Leu His
    50                  55                  60                  
Lys Asn Thr Val Leu Cys Asn Val Val Glu Gln Phe Leu Gln Ala Asp
65                  70                  75                  80  
Leu Ala Arg Glu Pro Pro Ala Asp Val Trp Thr Pro Pro Ala Arg Ala
                85                  90                  95      
Ser Ala Pro Ser Pro Asn Ala Gln Val Ala Cys Asp His Cys Leu Lys
            100                 105                 110         
Glu Ala Ala Val Lys Thr Cys Leu Val Cys Met Ala Ser Phe Cys Gln
        115                 120                 125             
Glu His Leu Gln Pro His Phe Asp Ser Pro Ala Phe Gln Asp His Pro
    130                 135                 140                 
Leu Gln Pro Pro Val Arg Asp Leu Leu Arg Arg Lys Cys Ser Gln His
145                 150                 155                 160 
Asn Arg Leu Arg Glu Phe Phe Cys Pro Glu His Ser Glu Cys Ile Cys
                165                 170                 175     
His Ile Cys Leu Val Glu His Lys Thr Cys Ser Pro Ala Ser Leu Ser
            180                 185                 190         
Gln Ala Ser Ala Asp Leu Glu Ala Thr Leu Arg His Lys Leu Thr Val
        195                 200                 205             
Met Tyr Ser Gln Ile Asn Gly Ala Ser Arg Ala Leu Asp Asp Val Arg
    210                 215                 220                 
Asn Arg Gln Gln Asp Val Arg Met Thr Ala Asn Arg Lys Val Glu Gln
225                 230                 235                 240 
Leu Gln Gln Glu Tyr Thr Glu Met Lys Ala Leu Leu Asp Ala Ser Glu
                245                 250                 255     
Thr Thr Ser Thr Arg Lys Ile Lys Glu Glu Glu Lys Arg Val Asn Ser
            260                 265                 270         
Lys Phe Asp Thr Ile Tyr Gln Ile Leu Leu Lys Lys Lys Ser Glu Ile
        275                 280                 285             
Gln Thr Leu Lys Glu Glu Ile Glu Gln Ser Leu Thr Lys Arg Asp Glu
    290                 295                 300                 
Phe Glu Phe Leu Glu Lys Ala Ser Lys Leu Arg Gly Ile Ser Thr Lys
305                 310                 315                 320 
Pro Val Tyr Ile Pro Glu Val Glu Leu Asn His Lys Leu Ile Lys Gly
                325                 330                 335     
Ile His Gln Ser Thr Ile Asp Leu Lys Asn Glu Leu Lys Gln Cys Ile
            340                 345                 350         
Gly Arg Leu Gln Glu Leu Thr Pro Ser Ser Gly Asp Pro Gly Glu His
        355                 360                 365             
Asp Pro Ala Ser Thr His Lys Ser Thr Arg Pro Val Lys Lys Val Ser
    370                 375                 380                 
Lys Glu Glu Lys Lys Ser Lys Lys Pro Pro Pro Val Pro Ala Leu Pro
385                 390                 395                 400 
Ser Lys Leu Pro Thr Phe Gly Ala Pro Glu Gln Leu Val Asp Leu Lys
                405                 410                 415     
Gln Ala Gly Leu Glu Ala Ala Ala Lys Ala Thr Ser Ser His Pro Asn
            420                 425                 430         
Ser Thr Ser Leu Lys Ala Lys Val Leu Glu Thr Phe Leu Ala Lys Ser
        435                 440                 445             
Arg Pro Glu Leu Leu Glu Tyr Tyr Ile Lys Val Ile Leu Asp Tyr Asn
    450                 455                 460                 
Thr Ala His Asn Lys Val Ala Leu Ser Glu Cys Tyr Thr Val Ala Ser
465                 470                 475                 480 
Val Ala Glu Met Pro Gln Asn Tyr Arg Pro His Pro Gln Arg Phe Thr
                485                 490                 495     
Tyr Cys Ser Gln Val Leu Gly Leu His Cys Tyr Lys Lys Gly Ile His
            500                 505                 510         
Tyr Trp Glu Val Glu Leu Gln Lys Asn Asn Phe Cys Gly Val Gly Ile
        515                 520                 525             
Cys Tyr Gly Ser Met Asn Arg Gln Gly Pro Glu Ser Arg Leu Gly Arg
    530                 535                 540                 
Asn Ser Ala Ser Trp Cys Val Glu Trp Phe Asn Thr Lys Ile Ser Ala
545                 550                 555                 560 
Trp His Asn Asn Val Glu Lys Thr Leu Pro Ser Thr Lys Ala Thr Arg
                565                 570                 575     
Val Gly Val Leu Leu Asn Cys Asp His Gly Phe Val Ile Phe Phe Ala
            580                 585                 590         
Val Ala Asp Lys Val His Leu Met Tyr Lys Phe Arg Val Asp Phe Thr
        595                 600                 605             
Glu Ala Leu Tyr Pro Ala Phe Trp Val Phe Ser Ala Gly Ala Thr Leu
    610                 615                 620                 
Ser Ile Cys Ser Pro Lys
625                 630 


<210> 641
<211> 342
<212> PRT
<213> Homo sapiens

<400> 641
Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu
 1               5                  10                  15      
Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu
            20                  25                  30          
Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg
        35                  40                  45              
Leu Glu Trp Lys Leu Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val
    50                  55                  60                  
Leu Pro Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu
65                  70                  75                  80  
Gly Ile Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys
                85                  90                  95      
Ser Asn Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile
            100                 105                 110         
Val Asp Ser Ala Ser Glu Leu Thr Ala Gly Val Pro Asn Lys Val Gly
        115                 120                 125             
Thr Cys Val Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His
    130                 135                 140                 
Leu Asp Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys
145                 150                 155                 160 
Glu Gln Thr Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu Gln Ser
                165                 170                 175     
Glu Leu Met Val Thr Pro Ala Arg Gly Gly Asp Pro Arg Pro Thr Phe
            180                 185                 190         
Ser Cys Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Thr
        195                 200                 205             
Ala Pro Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val
    210                 215                 220                 
Gln Leu Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Thr
225                 230                 235                 240 
Val Thr Leu Thr Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His
                245                 250                 255     
Trp Met Lys Asp Val Ser Asp Leu Glu Arg Gly Ala Gly Arg Thr Arg
            260                 265                 270         
Arg Gly Gly Ala Asn Cys Arg Leu Cys Gly Arg Ile Arg Ala Gly Asn
        275                 280                 285             
Ser Ser Pro Gly Pro Gly Asp Pro Gly Arg Pro Gly Asp Ser Arg Pro
    290                 295                 300                 
Ala His Trp Gly His Leu Val Ala Lys Ala Ala Thr Pro Arg Arg Gly
305                 310                 315                 320 
Glu Glu Gly Pro Arg Lys Pro Gly Gly Arg Gly Gly Ala Cys Arg Thr
                325                 330                 335     
Glu Ser Val Gly Gly Thr
            340         


<210> 642
<211> 558
<212> PRT
<213> Homo sapiens

<400> 642
Met Tyr Arg Tyr Leu Gly Glu Ala Leu Leu Leu Ser Arg Ala Gly Pro
 1               5                  10                  15      
Ala Ala Leu Gly Ser Ala Ser Ala Asp Ser Ala Ala Leu Leu Gly Trp
            20                  25                  30          
Ala Arg Gly Gln Pro Ala Ala Ala Pro Gln Pro Gly Leu Ala Leu Ala
        35                  40                  45              
Ala Arg Arg His Tyr Ser Glu Ala Val Ala Asp Arg Glu Asp Asp Pro
    50                  55                  60                  
Asn Phe Phe Lys Met Val Glu Gly Phe Phe Asp Arg Gly Ala Ser Ile
65                  70                  75                  80  
Val Glu Asp Lys Leu Val Glu Asp Leu Arg Thr Arg Glu Ser Glu Glu
                85                  90                  95      
Gln Lys Arg Asn Arg Val Arg Gly Ile Leu Arg Ile Ile Lys Pro Cys
            100                 105                 110         
Asn His Val Leu Ser Leu Ser Phe Pro Ile Arg Arg Asp Asp Gly Ser
        115                 120                 125             
Trp Glu Val Ile Glu Gly Tyr Arg Ala Gln His Ser Gln His Arg Thr
    130                 135                 140                 
Pro Cys Lys Gly Gly Ile Arg Tyr Ser Thr Asp Val Ser Val Asp Glu
145                 150                 155                 160 
Val Lys Ala Leu Ala Ser Leu Met Thr Tyr Lys Cys Ala Val Val Asp
                165                 170                 175     
Val Pro Phe Gly Gly Ala Lys Ala Gly Val Lys Ile Asn Pro Lys Asn
            180                 185                 190         
Tyr Thr Asp Asn Glu Leu Glu Lys Ile Thr Arg Arg Phe Thr Met Glu
        195                 200                 205             
Leu Ala Lys Lys Gly Phe Ile Gly Pro Gly Ile Asp Val Pro Ala Pro
    210                 215                 220                 
Asp Met Ser Thr Gly Glu Arg Glu Met Ser Trp Ile Ala Asp Thr Tyr
225                 230                 235                 240 
Ala Ser Thr Ile Gly His Tyr Asp Ile Asn Ala His Ala Cys Val Thr
                245                 250                 255     
Gly Lys Pro Ile Ser Gln Gly Gly Ile His Gly Arg Ile Ser Ala Thr
            260                 265                 270         
Gly Arg Gly Val Phe His Gly Ile Glu Asn Phe Ile Asn Glu Ala Ser
        275                 280                 285             
Tyr Met Ser Ile Leu Gly Met Thr Pro Gly Phe Gly Asp Lys Thr Phe
    290                 295                 300                 
Val Val Gln Gly Phe Gly Asn Val Gly Leu His Ser Met Arg Tyr Leu
305                 310                 315                 320 
His Arg Phe Gly Ala Lys Cys Ile Ala Val Gly Glu Ser Asp Gly Ser
                325                 330                 335     
Ile Trp Asn Pro Asp Gly Ile Asp Pro Lys Glu Leu Glu Asp Phe Lys
            340                 345                 350         
Leu Gln His Gly Ser Ile Leu Gly Phe Pro Lys Ala Lys Pro Tyr Glu
        355                 360                 365             
Gly Ser Ile Leu Glu Ala Asp Cys Asp Ile Leu Ile Pro Ala Ala Ser
    370                 375                 380                 
Glu Lys Gln Leu Thr Lys Ser Asn Ala Pro Arg Val Lys Ala Lys Ile
385                 390                 395                 400 
Ile Ala Glu Gly Ala Asn Gly Pro Thr Thr Pro Glu Ala Asp Lys Ile
                405                 410                 415     
Phe Leu Glu Arg Asn Ile Met Val Ile Pro Asp Leu Tyr Leu Asn Ala
            420                 425                 430         
Gly Gly Val Thr Val Ser Tyr Phe Glu Trp Leu Lys Asn Leu Asn His
        435                 440                 445             
Val Ser Tyr Gly Arg Leu Thr Phe Lys Tyr Glu Arg Asp Ser Asn Tyr
    450                 455                 460                 
His Leu Leu Met Ser Val Gln Glu Ser Leu Glu Arg Lys Phe Gly Lys
465                 470                 475                 480 
His Gly Gly Thr Ile Pro Ile Val Pro Thr Ala Glu Phe Gln Asp Arg
                485                 490                 495     
Ile Ser Gly Ala Ser Glu Lys Asp Ile Val His Ser Gly Leu Ala Tyr
            500                 505                 510         
Thr Met Glu Arg Ser Ala Arg Gln Ile Met Arg Thr Ala Met Lys Tyr
        515                 520                 525             
Asn Leu Gly Leu Asp Leu Arg Thr Ala Ala Tyr Val Asn Ala Ile Glu
    530                 535                 540                 
Lys Val Phe Lys Val Tyr Asn Glu Ala Gly Val Thr Phe Thr
545                 550                 555             


<210> 643
<211> 346
<212> PRT
<213> Homo sapiens

<400> 643
Met Asp Thr Gly Pro Asp Gln Ser Tyr Phe Ser Gly Asn His Trp Phe
 1               5                  10                  15      
Val Phe Ser Val Tyr Leu Leu Thr Phe Leu Val Gly Leu Pro Leu Asn
            20                  25                  30          
Leu Leu Ala Leu Val Val Phe Val Gly Lys Leu Arg Cys Arg Pro Val
        35                  40                  45              
Ala Val Asp Val Leu Leu Leu Asn Leu Thr Ala Ser Asp Leu Leu Leu
    50                  55                  60                  
Leu Leu Phe Leu Pro Phe Arg Met Val Glu Ala Ala Asn Gly Met His
65                  70                  75                  80  
Trp Pro Leu Pro Phe Ile Leu Cys Pro Leu Ser Gly Phe Ile Phe Phe
                85                  90                  95      
Thr Thr Ile Tyr Leu Thr Ala Leu Phe Leu Ala Ala Val Ser Ile Glu
            100                 105                 110         
Arg Phe Leu Ser Val Ala His Pro Leu Trp Tyr Lys Thr Arg Pro Arg
        115                 120                 125             
Leu Gly Gln Ala Gly Leu Val Ser Val Ala Cys Trp Leu Leu Ala Ser
    130                 135                 140                 
Ala His Cys Ser Val Val Tyr Val Ile Glu Phe Ser Gly Asp Ile Ser
145                 150                 155                 160 
His Ser Gln Gly Thr Asn Gly Thr Cys Tyr Leu Glu Phe Trp Lys Asp
                165                 170                 175     
Gln Leu Ala Ile Leu Leu Pro Val Arg Leu Glu Met Ala Val Val Leu
            180                 185                 190         
Phe Val Val Pro Leu Ile Ile Thr Ser Tyr Cys Tyr Ser Arg Leu Val
        195                 200                 205             
Trp Ile Leu Gly Arg Gly Gly Ser His Arg Arg Gln Arg Arg Val Ala
    210                 215                 220                 
Gly Leu Val Ala Ala Thr Leu Leu Asn Phe Leu Val Cys Phe Gly Pro
225                 230                 235                 240 
Tyr Asn Val Ser His Val Val Gly Tyr Ile Cys Gly Glu Ser Pro Val
                245                 250                 255     
Trp Arg Ile Tyr Val Thr Leu Leu Ser Thr Leu Asn Ser Cys Val Asp
            260                 265                 270         
Pro Phe Val Tyr Tyr Phe Ser Ser Ser Gly Phe Gln Ala Asp Phe His
        275                 280                 285             
Glu Leu Leu Arg Arg Leu Cys Gly Leu Trp Gly Gln Trp Gln Gln Glu
    290                 295                 300                 
Ser Ser Met Glu Leu Lys Glu Gln Lys Gly Gly Glu Glu Gln Arg Ala
305                 310                 315                 320 
Asp Arg Pro Ala Glu Arg Lys Thr Ser Glu His Ser Gln Gly Cys Gly
                325                 330                 335     
Thr Gly Gly Gln Val Ala Cys Ala Glu Asn
            340                 345     


<210> 644
<211> 260
<212> PRT
<213> Homo sapiens

<400> 644
Met Lys Val Glu Val Leu Pro Ala Leu Thr Asp Asn Tyr Met Tyr Leu
 1               5                  10                  15      
Val Ile Asp Asp Glu Thr Lys Glu Ala Ala Ile Val Asp Pro Val Gln
            20                  25                  30          
Pro Gln Lys Val Val Asp Ala Ala Arg Lys His Gly Val Lys Leu Thr
        35                  40                  45              
Thr Val Leu Thr Thr His His His Trp Asp His Ala Gly Gly Asn Glu
    50                  55                  60                  
Lys Leu Val Lys Leu Glu Ser Gly Leu Lys Val Tyr Gly Gly Asp Asp
65                  70                  75                  80  
Arg Ile Gly Ala Leu Thr His Lys Ile Thr His Leu Ser Thr Leu Gln
                85                  90                  95      
Val Gly Ser Leu Asn Val Lys Cys Leu Ala Thr Pro Cys His Thr Ser
            100                 105                 110         
Gly His Ile Cys Tyr Phe Val Ser Lys Pro Gly Gly Ser Glu Pro Pro
        115                 120                 125             
Ala Val Phe Thr Gly Asp Thr Leu Phe Val Ala Gly Cys Gly Lys Phe
    130                 135                 140                 
Tyr Glu Gly Thr Ala Asp Glu Met Cys Lys Ala Leu Leu Glu Val Leu
145                 150                 155                 160 
Gly Arg Leu Pro Pro Asp Thr Arg Val Tyr Cys Gly His Glu Tyr Thr
                165                 170                 175     
Ile Asn Asn Leu Lys Phe Ala Arg His Val Glu Pro Gly Asn Ala Ala
            180                 185                 190         
Ile Arg Glu Lys Leu Ala Trp Ala Lys Glu Lys Tyr Ser Ile Gly Glu
        195                 200                 205             
Pro Thr Val Pro Ser Thr Leu Ala Glu Glu Phe Thr Tyr Asn Pro Phe
    210                 215                 220                 
Met Arg Val Arg Glu Lys Thr Val Gln Gln His Ala Gly Glu Thr Asp
225                 230                 235                 240 
Pro Val Thr Thr Met Arg Ala Val Arg Arg Glu Lys Asp Gln Phe Lys
                245                 250                 255     
Met Pro Arg Asp
            260 


<210> 645
<211> 260
<212> PRT
<213> Homo sapiens

<400> 645
Met Lys Val Glu Val Leu Pro Ala Leu Thr Asp Asn Tyr Met Tyr Leu
 1               5                  10                  15      
Val Ile Asp Asp Glu Thr Lys Glu Ala Ala Ile Val Asp Pro Val Gln
            20                  25                  30          
Pro Gln Lys Val Val Asp Ala Ala Arg Lys His Gly Val Lys Leu Thr
        35                  40                  45              
Thr Val Leu Thr Thr His His His Trp Asp His Ala Gly Gly Asn Glu
    50                  55                  60                  
Lys Leu Val Lys Leu Glu Ser Gly Leu Lys Val Tyr Gly Gly Asp Asp
65                  70                  75                  80  
Arg Ile Gly Ala Leu Thr His Lys Ile Thr His Leu Ser Thr Leu Gln
                85                  90                  95      
Val Gly Ser Leu Asn Val Lys Cys Leu Ala Thr Pro Cys His Thr Ser
            100                 105                 110         
Gly His Ile Cys Tyr Phe Val Ser Lys Pro Gly Gly Ser Glu Pro Pro
        115                 120                 125             
Ala Val Phe Thr Gly Asp Thr Leu Phe Val Ala Gly Cys Gly Lys Phe
    130                 135                 140                 
Tyr Glu Gly Thr Ala Asp Glu Met Cys Lys Ala Leu Leu Glu Val Leu
145                 150                 155                 160 
Gly Arg Leu Pro Pro Asp Thr Arg Val Tyr Cys Gly His Glu Tyr Thr
                165                 170                 175     
Ile Asn Asn Leu Lys Phe Ala Arg His Val Glu Pro Gly Asn Ala Ala
            180                 185                 190         
Ile Arg Glu Lys Leu Ala Trp Ala Lys Glu Lys Tyr Ser Ile Gly Glu
        195                 200                 205             
Pro Thr Val Pro Ser Thr Leu Ala Glu Glu Phe Thr Tyr Asn Pro Phe
    210                 215                 220                 
Met Arg Val Arg Glu Lys Thr Val Gln Gln His Ala Gly Glu Thr Asp
225                 230                 235                 240 
Pro Val Thr Thr Met Arg Ala Val Arg Arg Glu Lys Asp Gln Phe Lys
                245                 250                 255     
Met Pro Arg Asp
            260 


<210> 646
<211> 268
<212> PRT
<213> Homo sapiens

<400> 646
Met Gly Leu Ser Pro Ser Ala Pro Ala Val Ala Val Gln Ala Ser Asn
 1               5                  10                  15      
Ala Ser Ala Ser Pro Pro Ser Gly Cys Pro Met His Glu Gly Lys Met
            20                  25                  30          
Lys Gly Cys Pro Val Asn Thr Glu Pro Ser Gly Pro Thr Cys Glu Lys
        35                  40                  45              
Lys Thr Tyr Ser Val Pro Ala His Gln Glu Arg Ala Tyr Glu Tyr Val
    50                  55                  60                  
Glu Cys Pro Ile Arg Gly Thr Ala Ala Glu Asn Lys Glu Asn Leu Asp
65                  70                  75                  80  
Pro Ser Asn Leu Met Pro Pro Pro Asn Gln Thr Pro Ala Pro Asp Gln
                85                  90                  95      
Pro Phe Ala Leu Ser Thr Val Arg Glu Glu Ser Ser Ile Pro Arg Ala
            100                 105                 110         
Asp Ser Glu Lys Lys Trp Val Tyr Pro Ser Glu Gln Met Phe Trp Asn
        115                 120                 125             
Ala Met Leu Lys Lys Gly Trp Lys Trp Lys Asp Glu Asp Ile Ser Gln
    130                 135                 140                 
Lys Asp Met Tyr Asn Ile Ile Arg Ile His Asn Gln Asn Asn Glu Gln
145                 150                 155                 160 
Ala Trp Lys Glu Ile Leu Lys Trp Glu Ala Leu His Ala Ala Glu Cys
                165                 170                 175     
Pro Cys Gly Pro Ser Leu Ile Arg Phe Gly Gly Lys Ala Lys Glu Tyr
            180                 185                 190         
Ser Pro Arg Ala Arg Ile Arg Ser Trp Met Gly Tyr Glu Leu Pro Phe
        195                 200                 205             
Asp Arg His Asp Trp Ile Ile Asn Arg Cys Gly Thr Glu Val Arg Tyr
    210                 215                 220                 
Val Ile Asp Tyr Tyr Asp Gly Gly Glu Val Asn Lys Asp Tyr Gln Phe
225                 230                 235                 240 
Thr Ile Leu Asp Val Arg Pro Ala Leu Asp Ser Leu Ser Ala Val Trp
                245                 250                 255     
Asp Arg Met Lys Val Ala Trp Trp Arg Trp Thr Ser
            260                 265             


<210> 647
<211> 435
<212> PRT
<213> Homo sapiens

<400> 647
Met Ala Pro Phe Gly Arg Asn Leu Leu Lys Thr Arg His Lys Asn Arg
 1               5                  10                  15      
Ser Pro Thr Lys Asp Met Asp Ser Glu Glu Lys Glu Ile Val Val Trp
            20                  25                  30          
Val Cys Gln Glu Glu Lys Phe Val Cys Gly Leu Thr Lys Arg Thr Thr
        35                  40                  45              
Ser Ala Asp Val Ile Gln Ala Leu Leu Glu Glu His Glu Ala Thr Phe
    50                  55                  60                  
Gly Glu Lys Arg Phe Leu Leu Gly Lys Pro Ser Asp Tyr Cys Ile Ile
65                  70                  75                  80  
Glu Lys Trp Arg Gly Ser Glu Arg Val Leu Pro Pro Leu Thr Arg Ile
                85                  90                  95      
Leu Lys Leu Trp Lys Ala Trp Gly Asp Glu Gln Pro Asn Met Gln Phe
            100                 105                 110         
Val Leu Val Lys Ala Asp Ala Phe Leu Pro Val Pro Leu Trp Arg Thr
        115                 120                 125             
Ala Glu Ala Lys Leu Val Gln Asn Thr Glu Lys Leu Trp Glu Leu Ser
    130                 135                 140                 
Pro Ala Asn Tyr Met Lys Thr Leu Pro Pro Asp Lys Gln Lys Arg Ile
145                 150                 155                 160 
Val Arg Lys Thr Phe Arg Lys Leu Ala Lys Ile Lys Gln Asp Thr Val
                165                 170                 175     
Ser His Asp Arg Asp Asn Met Glu Thr Leu Val His Leu Ile Ile Ser
            180                 185                 190         
Gln Asp His Thr Ile His Gln Gln Val Lys Arg Met Lys Glu Leu Asp
        195                 200                 205             
Leu Glu Ile Glu Lys Cys Glu Ala Lys Phe His Leu Asp Arg Val Glu
    210                 215                 220                 
Asn Asp Gly Glu Asn Tyr Val Gln Asp Ala Tyr Leu Met Pro Ser Phe
225                 230                 235                 240 
Ser Glu Val Glu Gln Asn Leu Asp Leu Gln Tyr Glu Glu Asn Gln Thr
                245                 250                 255     
Leu Glu Asp Leu Ser Glu Ser Asp Gly Ile Glu Gln Leu Glu Glu Arg
            260                 265                 270         
Leu Lys Tyr Tyr Arg Ile Leu Ile Asp Lys Leu Ser Ala Glu Ile Glu
        275                 280                 285             
Lys Glu Val Lys Ser Val Cys Ile Asp Ile Asn Glu Asp Ala Glu Gly
    290                 295                 300                 
Glu Ala Ala Ser Glu Leu Glu Ser Ser Asn Leu Glu Ser Val Lys Cys
305                 310                 315                 320 
Asp Leu Glu Lys Ser Met Lys Ala Gly Leu Lys Ile His Ser His Leu
                325                 330                 335     
Ser Gly Ile Gln Lys Glu Ile Lys Tyr Ser Asp Ser Leu Leu Gln Met
            340                 345                 350         
Lys Ala Lys Glu Tyr Glu Leu Leu Ala Lys Glu Phe Asn Ser Leu His
        355                 360                 365             
Ile Ser Asn Lys Asp Gly Cys Gln Leu Lys Glu Asn Arg Ala Lys Glu
    370                 375                 380                 
Ser Glu Val Pro Ser Ser Asn Gly Glu Ile Pro Pro Phe Thr Gln Arg
385                 390                 395                 400 
Val Phe Ser Asn Tyr Thr Asn Asp Thr Asp Ser Asp Thr Gly Ile Ser
                405                 410                 415     
Ser Asn His Ser Gln Asp Ser Glu Thr Thr Val Gly Asp Val Val Leu
            420                 425                 430         
Leu Ser Thr
        435 


<210> 648
<211> 264
<212> PRT
<213> Homo sapiens

<400> 648
Met Cys Pro Trp Arg Pro Arg Leu Gly Arg Arg Cys Met Val Ser Pro
 1               5                  10                  15      
Arg Glu Ala Asp Leu Gly Pro Gln Lys Asp Thr Arg Leu Asp Leu Pro
            20                  25                  30          
Arg Ser Pro Ala Arg Ala Pro Arg Glu Gln Asn Ser Leu Gly Glu Val
        35                  40                  45              
Asp Arg Arg Gly Pro Arg Glu Gln Thr Arg Ala Pro Ala Thr Ala Ala
    50                  55                  60                  
Pro Pro Arg Pro Leu Gly Ser Arg Gly Ala Glu Ala Ala Glu Pro Gln
65                  70                  75                  80  
Glu Gly Leu Ser Ala Thr Val Ser Ala Cys Phe Gln Glu Gln Gln Glu
                85                  90                  95      
Met Asn Thr Leu Gln Gly Pro Val Ser Phe Lys Asp Val Ala Val Asp
            100                 105                 110         
Phe Thr Gln Glu Glu Trp Arg Gln Leu Asp Pro Asp Glu Lys Ile Ala
        115                 120                 125             
Tyr Gly Asp Val Met Leu Glu Asn Tyr Ser His Leu Val Ser Val Gly
    130                 135                 140                 
Tyr Asp Tyr His Gln Ala Lys His His His Gly Val Glu Val Lys Glu
145                 150                 155                 160 
Val Glu Gln Gly Glu Glu Pro Trp Ile Met Glu Gly Glu Phe Pro Cys
                165                 170                 175     
Gln His Ser Pro Glu Pro Ala Lys Ala Ile Lys Pro Ile Asp Arg Lys
            180                 185                 190         
Ser Val His Gln Ile Cys Ser Gly Pro Val Val Leu Ser Leu Ser Thr
        195                 200                 205             
Ala Val Lys Glu Leu Val Glu Asn Ser Leu Asp Ala Gly Ala Thr Asn
    210                 215                 220                 
Ile Asp Leu Lys Leu Lys Asp Tyr Gly Val Asp Leu Ile Glu Val Ser
225                 230                 235                 240 
Asp Asn Gly Cys Gly Val Glu Glu Glu Asn Phe Glu Gly Leu Ile Ser
                245                 250                 255     
Phe Ser Ser Glu Thr Ser His Met
            260                 


<210> 649
<211> 319
<212> PRT
<213> Homo sapiens

<400> 649
Met Ser Ser Pro Gln Ala Pro Glu Asp Gly Gln Gly Cys Gly Asp Arg
 1               5                  10                  15      
Gly Asp Pro Pro Gly Asp Leu Arg Ser Val Leu Val Thr Thr Val Leu
            20                  25                  30          
Asn Leu Glu Pro Leu Asp Glu Asp Leu Phe Arg Gly Arg His Tyr Trp
        35                  40                  45              
Val Pro Ala Lys Arg Leu Phe Gly Gly Gln Ile Val Gly Gln Ala Leu
    50                  55                  60                  
Val Ala Ala Ala Lys Ser Val Ser Glu Asp Val His Val His Ser Leu
65                  70                  75                  80  
His Cys Tyr Phe Val Arg Ala Gly Asp Pro Lys Leu Pro Val Leu Tyr
                85                  90                  95      
Gln Val Glu Arg Thr Arg Thr Gly Ser Ser Phe Ser Val Arg Ser Val
            100                 105                 110         
Lys Ala Val Gln His Gly Lys Pro Ile Phe Ile Cys Gln Ala Ser Phe
        115                 120                 125             
Gln Gln Ala Gln Pro Ser Pro Met Gln His Gln Phe Ser Met Pro Thr
    130                 135                 140                 
Val Pro Pro Pro Glu Glu Leu Leu Asp Cys Glu Thr Leu Ile Asp Gln
145                 150                 155                 160 
Tyr Leu Arg Asp Pro Asn Leu Gln Lys Arg Tyr Pro Leu Ala Leu Asn
                165                 170                 175     
Arg Ile Ala Ala Gln Glu Val Pro Ile Glu Ile Lys Pro Val Asn Pro
            180                 185                 190         
Ser Pro Leu Ser Gln Leu Gln Arg Met Glu Pro Lys Gln Met Phe Trp
        195                 200                 205             
Val Arg Ala Arg Gly Tyr Ile Gly Glu Gly Asp Met Lys Met His Cys
    210                 215                 220                 
Cys Val Ala Ala Tyr Ile Ser Asp Tyr Ala Phe Leu Gly Thr Ala Leu
225                 230                 235                 240 
Leu Pro His Gln Trp Gln His Lys Val His Phe Met Val Ser Leu Asp
                245                 250                 255     
His Ser Met Trp Phe His Ala Pro Phe Arg Ala Asp His Trp Met Leu
            260                 265                 270         
Tyr Glu Cys Glu Ser Pro Trp Ala Gly Gly Ser Arg Gly Leu Val His
        275                 280                 285             
Gly Arg Val Trp Ser Gln Asp Gly Val Leu Ala Val Thr Cys Ala Gln
    290                 295                 300                 
Glu Gly Val Ile Arg Val Lys Pro Gln Val Ser Glu Ser Lys Arg
305                 310                 315                 


<210> 650
<211> 851
<212> PRT
<213> Homo sapiens

<400> 650
Met Ala Gln Trp Glu Met Leu Gln Asn Leu Asp Ser Pro Phe Gln Asp
 1               5                  10                  15      
Gln Leu His Gln Leu Tyr Ser His Ser Leu Leu Pro Val Asp Ile Arg
            20                  25                  30          
Gln Tyr Leu Ala Val Trp Ile Glu Asp Gln Asn Trp Gln Glu Ala Ala
        35                  40                  45              
Leu Gly Ser Asp Asp Ser Lys Ala Thr Met Leu Phe Phe His Phe Leu
    50                  55                  60                  
Asp Gln Leu Asn Tyr Glu Cys Gly Arg Cys Ser Gln Asp Pro Glu Ser
65                  70                  75                  80  
Leu Leu Leu Gln His Asn Leu Arg Lys Phe Cys Arg Asp Ile Gln Pro
                85                  90                  95      
Phe Ser Gln Asp Pro Thr Gln Leu Ala Glu Met Ile Phe Asn Leu Leu
            100                 105                 110         
Leu Glu Glu Lys Arg Ile Leu Ile Gln Ala Gln Arg Ala Gln Leu Glu
        115                 120                 125             
Gln Gly Glu Pro Val Leu Glu Thr Pro Val Glu Ser Gln Gln His Glu
    130                 135                 140                 
Ile Glu Ser Arg Ile Leu Asp Leu Arg Ala Met Met Glu Lys Leu Val
145                 150                 155                 160 
Lys Ser Ile Ser Gln Leu Lys Asp Gln Gln Asp Val Phe Cys Phe Arg
                165                 170                 175     
Tyr Lys Ile Gln Ala Lys Gly Lys Thr Pro Ser Leu Asp Pro His Gln
            180                 185                 190         
Thr Lys Glu Gln Lys Ile Leu Gln Glu Thr Leu Asn Glu Leu Asp Lys
        195                 200                 205             
Arg Arg Lys Glu Val Leu Asp Ala Ser Lys Ala Leu Leu Gly Arg Leu
    210                 215                 220                 
Thr Thr Leu Ile Glu Leu Leu Leu Pro Lys Leu Glu Glu Trp Lys Ala
225                 230                 235                 240 
Gln Gln Gln Lys Ala Cys Ile Arg Ala Pro Ile Asp His Gly Leu Glu
                245                 250                 255     
Gln Leu Glu Thr Trp Phe Thr Ala Gly Ala Lys Leu Leu Phe His Leu
            260                 265                 270         
Arg Gln Leu Leu Lys Glu Leu Lys Gly Leu Ser Cys Leu Val Ser Tyr
        275                 280                 285             
Gln Asp Asp Pro Leu Thr Lys Gly Val Asp Leu Arg Asn Ala Gln Val
    290                 295                 300                 
Thr Glu Leu Leu Gln Arg Leu Leu His Arg Ala Phe Val Val Glu Thr
305                 310                 315                 320 
Gln Pro Cys Met Pro Gln Thr Pro His Arg Pro Leu Ile Leu Lys Thr
                325                 330                 335     
Gly Ser Lys Phe Thr Val Arg Thr Arg Leu Leu Val Arg Leu Gln Glu
            340                 345                 350         
Gly Asn Glu Ser Leu Thr Val Glu Val Ser Ile Asp Arg Asn Pro Pro
        355                 360                 365             
Gln Leu Gln Gly Phe Arg Lys Phe Asn Ile Leu Thr Ser Asn Gln Lys
    370                 375                 380                 
Thr Leu Thr Pro Glu Lys Gly Gln Ser Gln Gly Leu Ile Trp Asp Phe
385                 390                 395                 400 
Gly Tyr Leu Thr Leu Val Glu Gln Arg Ser Gly Gly Ser Gly Lys Gly
                405                 410                 415     
Ser Asn Lys Gly Pro Leu Gly Val Thr Glu Glu Leu His Ile Ile Ser
            420                 425                 430         
Phe Thr Val Lys Tyr Thr Tyr Gln Gly Leu Lys Gln Glu Leu Lys Thr
        435                 440                 445             
Asp Thr Leu Pro Val Val Ile Ile Ser Asn Met Asn Gln Leu Ser Ile
    450                 455                 460                 
Ala Trp Ala Ser Val Leu Trp Phe Asn Leu Leu Ser Pro Asn Leu Gln
465                 470                 475                 480 
Asn Gln Gln Phe Phe Ser Asn Pro Pro Lys Ala Pro Trp Ser Leu Leu
                485                 490                 495     
Gly Pro Ala Leu Ser Trp Gln Phe Ser Ser Tyr Val Gly Arg Gly Leu
            500                 505                 510         
Asn Ser Asp Gln Leu Ser Met Leu Arg Asn Lys Leu Phe Gly Gln Asn
        515                 520                 525             
Cys Arg Thr Glu Asp Pro Leu Leu Ser Trp Ala Asp Phe Thr Lys Arg
    530                 535                 540                 
Glu Ser Pro Pro Gly Lys Leu Pro Phe Trp Thr Trp Leu Asp Lys Ile
545                 550                 555                 560 
Leu Glu Leu Val His Asp His Leu Lys Asp Leu Trp Asn Asp Gly Arg
                565                 570                 575     
Ile Met Gly Phe Val Ser Arg Ser Gln Glu Arg Arg Leu Leu Lys Lys
            580                 585                 590         
Thr Met Ser Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Glu Gly
        595                 600                 605             
Gly Ile Thr Cys Ser Trp Val Glu His Gln Asp Asp Asp Lys Val Leu
    610                 615                 620                 
Ile Tyr Ser Val Gln Pro Tyr Thr Lys Glu Val Leu Gln Ser Leu Pro
625                 630                 635                 640 
Leu Thr Glu Ile Ile Arg His Tyr Gln Leu Leu Thr Glu Glu Asn Ile
                645                 650                 655     
Pro Glu Asn Pro Leu Arg Phe Leu Tyr Pro Arg Ile Pro Arg Asp Glu
            660                 665                 670         
Ala Phe Gly Cys Tyr Tyr Gln Glu Lys Val Asn Leu Gln Glu Arg Arg
        675                 680                 685             
Lys Tyr Leu Lys His Arg Leu Ile Val Val Ser Asn Arg Gln Val Asp
    690                 695                 700                 
Glu Leu Gln Gln Pro Leu Glu Leu Lys Pro Glu Pro Glu Leu Glu Ser
705                 710                 715                 720 
Leu Glu Leu Glu Leu Gly Leu Val Pro Glu Pro Glu Leu Ser Leu Asp
                725                 730                 735     
Leu Glu Pro Leu Leu Lys Ala Gly Leu Asp Leu Gly Pro Glu Leu Glu
            740                 745                 750         
Ser Val Leu Glu Ser Thr Leu Glu Pro Val Ile Glu Pro Thr Leu Cys
        755                 760                 765             
Met Val Ser Gln Thr Val Pro Glu Pro Asp Gln Gly Pro Val Ser Gln
    770                 775                 780                 
Pro Val Pro Glu Pro Asp Leu Pro Cys Asp Leu Arg His Leu Asn Thr
785                 790                 795                 800 
Glu Pro Met Glu Ile Phe Arg Asn Cys Val Lys Ile Glu Glu Ile Met
                805                 810                 815     
Pro Asn Gly Asp Pro Leu Leu Ala Gly Gln Asn Thr Val Asp Glu Val
            820                 825                 830         
Tyr Val Ser Arg Pro Ser His Phe Tyr Thr Asp Gly Pro Leu Met Pro
        835                 840                 845             
Ser Asp Phe
    850     


<210> 651
<211> 193
<212> PRT
<213> Homo sapiens

<400> 651
Met Asp Gly Gly Thr Leu Pro Arg Ser Ala Pro Pro Ala Pro Pro Val
 1               5                  10                  15      
Pro Val Gly Cys Ala Ala Arg Arg Arg Pro Ala Ser Pro Glu Leu Leu
            20                  25                  30          
Arg Cys Ser Arg Arg Arg Arg Pro Ala Thr Ala Glu Thr Gly Gly Gly
        35                  40                  45              
Ala Ala Ala Val Ala Arg Arg Asn Glu Arg Glu Arg Asn Arg Val Lys
    50                  55                  60                  
Leu Val Asn Leu Gly Phe Gln Ala Leu Arg Gln His Val Pro His Gly
65                  70                  75                  80  
Gly Ala Ser Lys Lys Leu Ser Lys Val Glu Thr Leu Arg Ser Ala Val
                85                  90                  95      
Glu Tyr Ile Arg Ala Leu Gln Arg Leu Leu Ala Glu His Asp Ala Val
            100                 105                 110         
Arg Asn Ala Leu Ala Gly Gly Leu Arg Pro Gln Ala Val Arg Pro Ser
        115                 120                 125             
Ala Pro Arg Gly Pro Pro Gly Thr Thr Pro Val Ala Ala Ser Pro Ser
    130                 135                 140                 
Arg Ala Ser Ser Ser Pro Gly Arg Gly Gly Ser Ser Glu Pro Gly Ser
145                 150                 155                 160 
Pro Arg Ser Ala Tyr Ser Ser Asp Asp Ser Gly Cys Glu Gly Ala Leu
                165                 170                 175     
Ser Pro Ala Glu Arg Glu Leu Leu Asp Phe Ser Ser Trp Leu Gly Gly
            180                 185                 190         
Tyr
    


<210> 652
<211> 117
<212> PRT
<213> Homo sapiens

<400> 652
Arg Arg Gly Ser Gly Cys Ser Pro Ser Ala Asp Gln Gln Gly Ala Gln
 1               5                  10                  15      
Asp Arg Glu Glu Glu Ala Ala Ala Ala Pro Ala Pro Thr Ser Arg Gly
            20                  25                  30          
His Arg Thr Glu Lys Arg Lys Arg Leu Gln Leu Gln Cys Gln Pro Ala
        35                  40                  45              
Gly Gly Thr Gly Gln Arg Arg Gly Ser Gly Ser Ser Pro Ser Ala Asp
    50                  55                  60                  
Gln Gln Arg Ala Gln Asp Arg Glu Glu Glu Ala Ala Ala Ala Pro Ala
65                  70                  75                  80  
Pro Thr Ser Ser Gly His Arg Thr Glu Lys Arg Lys Arg Gln Gln Pro
                85                  90                  95      
Gln Arg Arg Pro Ala Ala Gly Thr Gly Gln Lys Arg Gly Ser Glu Glu
            100                 105                 110         
Met Glu Glu Glu Gly
        115         


<210> 653
<211> 179
<212> PRT
<213> Homo sapiens

<400> 653
Met Ala Phe Leu Ala Ser Gly Pro Tyr Leu Thr His Gln Gln Lys Val
 1               5                  10                  15      
Leu Arg Leu Tyr Lys Arg Ala Leu Arg His Leu Glu Ser Trp Cys Val
            20                  25                  30          
Gln Arg Asp Lys Tyr Arg Tyr Phe Ala Cys Leu Met Arg Ala Arg Phe
        35                  40                  45              
Glu Glu His Lys Asn Glu Lys Asp Met Ala Lys Ala Thr Gln Leu Leu
    50                  55                  60                  
Lys Glu Ala Glu Glu Glu Phe Trp Tyr Arg Gln His Pro Gln Pro Tyr
65                  70                  75                  80  
Ile Phe Pro Asp Ser Pro Gly Gly Thr Ser Tyr Glu Arg Tyr Asp Cys
                85                  90                  95      
Tyr Lys Val Pro Glu Trp Cys Leu Asp Asp Trp His Pro Ser Glu Lys
            100                 105                 110         
Ala Met Tyr Pro Asp Tyr Phe Ala Lys Arg Glu Gln Trp Lys Lys Leu
        115                 120                 125             
Arg Arg Glu Ser Trp Glu Arg Glu Val Lys Gln Leu Gln Glu Glu Thr
    130                 135                 140                 
Pro Ser Gly Gly Pro Leu Thr Glu Ala Leu Pro Pro Ala Arg Lys Glu
145                 150                 155                 160 
Gly Asp Leu Pro Pro Leu Trp Trp Tyr Ile Val Thr Arg Pro Arg Glu
                165                 170                 175     
Arg Pro Met
            


<210> 654
<211> 892
<212> PRT
<213> Homo sapiens

<400> 654
Gly Gly Asp Glu Gln Val Arg Asp Ala Ala Ala Val Pro Ala Gly Leu
 1               5                  10                  15      
Pro Arg Leu Glu Gly Gly Asp Lys Thr Leu Arg Glu Pro Gly Ala Gly
            20                  25                  30          
Ala Gln Glu Val Thr Leu Lys Val His Ile Ser Asp Ala Ser Thr His
        35                  40                  45              
Gln Pro Val Ala Asp Ala Leu Ile Glu Ile Phe Thr Asn Gln Ala Ser
    50                  55                  60                  
Ile Ala Ser Gly Thr Ser Gly Thr Asp Gly Val Ala Phe Ile Lys Phe
65                  70                  75                  80  
Gln Tyr Lys Leu Gly Ser Gln Leu Ile Val Thr Ala Ser Lys His Ala
                85                  90                  95      
Tyr Val Pro Asn Ser Ala Pro Trp Lys Pro Ile Arg Leu Pro Val Phe
            100                 105                 110         
Ser Ser Leu Ser Leu Gly Leu Leu Pro Glu Arg Ser Ala Thr Leu Met
        115                 120                 125             
Val Tyr Glu Asp Val Val Gln Ile Val Ser Gly Phe Gln Gly Ala Arg
    130                 135                 140                 
Pro Gln Pro Arg Val His Phe Gln Arg Arg Ala Leu Arg Leu Pro Glu
145                 150                 155                 160 
Asn Thr Ser Tyr Ser Asp Leu Thr Ala Phe Leu Thr Ala Ala Ser Ser
                165                 170                 175     
Pro Ser Glu Val Asp Ser Phe Pro Tyr Leu Arg Gly Leu Asp Gly Asn
            180                 185                 190         
Gly Thr Gly Asn Ser Thr Arg His Asp Leu Thr Pro Val Thr Ala Val
        195                 200                 205             
Ser Val His Leu Leu Ser Ser Asn Gly Thr Pro Val Leu Val Asp Gly
    210                 215                 220                 
Pro Ile Tyr Val Thr Val Pro Leu Ala Thr Gln Ser Ser Leu Arg His
225                 230                 235                 240 
Asn Ala Tyr Val Ala Ala Trp Arg Phe Asp Gln Lys Leu Gly Thr Trp
                245                 250                 255     
Leu Lys Ser Gly Leu Gly Leu Val His Gln Glu Gly Ser Gln Leu Thr
            260                 265                 270         
Trp Thr Tyr Ile Ala Pro Gln Leu Gly Tyr Trp Val Ala Ala Met Ser
        275                 280                 285             
Pro Pro Ile Pro Gly Pro Val Val Thr Gln Asp Ile Thr Thr Tyr His
    290                 295                 300                 
Thr Val Phe Leu Leu Ala Ile Leu Gly Gly Met Ala Phe Ile Leu Leu
305                 310                 315                 320 
Val Leu Leu Cys Leu Leu Leu Tyr Tyr Cys Arg Arg Lys Cys Leu Lys
                325                 330                 335     
Pro Arg Gln His His Arg Lys Leu Gln Leu Pro Ala Gly Leu Glu Ser
            340                 345                 350         
Ser Lys Arg Asp Gln Ser Thr Ser Met Ser His Ile Asn Leu Leu Phe
        355                 360                 365             
Ser Arg Arg Ala Ser Glu Phe Pro Gly Pro Leu Ser Val Thr Ser His
    370                 375                 380                 
Gly Arg Pro Glu Ala Pro Gly Thr Lys Glu Leu Met Ser Gly Val His
385                 390                 395                 400 
Leu Glu Met Met Ser Pro Gly Gly Glu Gly Asp Leu His Thr Pro Met
                405                 410                 415     
Leu Lys Leu Ser Tyr Ser Thr Ser Gln Glu Phe Ser Ser Arg Glu Glu
            420                 425                 430         
Leu Leu Ser Cys Lys Glu Glu Asp Lys Ser Gln Ile Ser Phe Asp Asn
        435                 440                 445             
Leu Thr Pro Ser Gly Thr Leu Gly Lys Asp Tyr His Lys Ser Val Glu
    450                 455                 460                 
Val Phe Ser Leu Lys Ala Arg Lys Ser Met Glu Arg Glu Gly Tyr Glu
465                 470                 475                 480 
Ser Ser Gly Met Met Thr Thr Gly Val Val Thr Thr Pro Cys Ser His
                485                 490                 495     
Ser Leu Tyr Leu Lys Ser Arg Thr Glu Lys Val Gln Pro Pro Arg Glu
            500                 505                 510         
Ala Asn Ser Pro Phe Arg Asn Ile Cys Thr Pro Arg Leu His His Leu
        515                 520                 525             
Arg Lys Asn Ser Cys Trp Thr Ala Asp Pro Leu Asn Val Met Met Ser
    530                 535                 540                 
Arg Ser Val Asp His Leu Glu Arg Pro Thr Ser Phe Pro Arg Pro Gly
545                 550                 555                 560 
Gln Leu Ile Cys Cys Ser Ser Val Asp Gln Val Asn Asp Ser Val Tyr
                565                 570                 575     
Arg Lys Val Leu Pro Ala Leu Val Ile Pro Ala His Tyr Met Lys Leu
            580                 585                 590         
Pro Gly Asp His Ser Tyr Val Ser Gln Pro Leu Val Val Pro Ala Asp
        595                 600                 605             
Gln Gln Leu Glu Ile Glu Arg Leu Gln Ala Glu Leu Ser Asn Pro His
    610                 615                 620                 
Ala Gly Ile Phe Pro His Pro Ser Ser Gln Ile Gln Pro Gln Pro Leu
625                 630                 635                 640 
Ser Ser Gln Ala Ile Ser Gln Gln His Leu Gln Asp Ala Gly Thr Arg
                645                 650                 655     
Glu Trp Ser Pro Gln Asn Ala Ser Met Ser Glu Ser Leu Ser Ile Pro
            660                 665                 670         
Ala Ser Leu Asn Asp Ala Ala Leu Ala Gln Met Asn Ser Glu Val Gln
        675                 680                 685             
Leu Leu Thr Glu Lys Ala Leu Met Glu Leu Gly Gly Gly Lys Pro Leu
    690                 695                 700                 
Pro His Thr Arg Ala Trp Phe Val Ser Leu Asp Gly Arg Ser Asn Ala
705                 710                 715                 720 
His Val Arg His Ser Tyr Ile Asp Leu Gln Arg Ala Gly Arg Asn Gly
                725                 730                 735     
Ser Asn Asp Ala Ser Leu Asp Ser Gly Val Asp Met Asn Glu Pro Lys
            740                 745                 750         
Ser Ala Arg Lys Gly Arg Gly Asp Ala Leu Ser Leu Gln Gln Asn Tyr
        755                 760                 765             
Pro Pro Val Gln Glu His Gln Gln Lys Glu Pro Arg Ala Pro Asp Ser
    770                 775                 780                 
Thr Ala Tyr Thr Gln Leu Val Tyr Leu Asp Asp Val Glu Gln Ser Gly
785                 790                 795                 800 
Ser Glu Cys Gly Thr Thr Val Cys Thr Pro Glu Asp Ser Ala Leu Arg
                805                 810                 815     
Cys Leu Leu Glu Gly Ser Ser Arg Arg Ser Gly Gly Gln Leu Pro Ser
            820                 825                 830         
Leu Gln Glu Glu Thr Thr Arg Arg Thr Ala Asp Ala Pro Ser Glu Pro
        835                 840                 845             
Ala Ala Ser Pro His Gln Arg Arg Ser Ala His Glu Glu Glu Glu Asp
    850                 855                 860                 
Asp Asp Asp Asp Asp Gln Gly Glu Asp Lys Lys Ser Pro Trp Gln Lys
865                 870                 875                 880 
Arg Glu Glu Arg Pro Leu Met Ala Phe Asn Ile Lys
                885                 890         


<210> 655
<211> 205
<212> PRT
<213> Homo sapiens

<400> 655
Met Ala Ala Gly Glu Ser Met Ala Gln Arg Met Val Trp Val Asp Leu
 1               5                  10                  15      
Glu Met Thr Gly Leu Asp Ile Glu Lys Asp Gln Ile Ile Glu Met Ala
            20                  25                  30          
Cys Leu Ile Thr Asp Ser Asp Leu Asn Ile Leu Ala Glu Gly Pro Asn
        35                  40                  45              
Leu Ile Ile Lys Gln Pro Asp Glu Leu Leu Asp Ser Met Ser Asp Trp
    50                  55                  60                  
Cys Lys Glu His His Gly Lys Ser Gly Leu Thr Lys Ala Val Lys Glu
65                  70                  75                  80  
Ser Thr Ile Thr Leu Gln Gln Ala Glu Tyr Glu Phe Leu Ser Phe Val
                85                  90                  95      
Arg Gln Gln Thr Pro Pro Gly Leu Cys Pro Leu Ala Gly Asn Ser Val
            100                 105                 110         
His Glu Asp Lys Lys Phe Leu Asp Lys Tyr Met Pro Gln Phe Met Lys
        115                 120                 125             
His Leu His Tyr Arg Ile Ile Asp Val Ser Thr Val Lys Glu Leu Cys
    130                 135                 140                 
Arg Arg Trp Tyr Pro Glu Glu Tyr Glu Phe Ala Pro Lys Lys Ala Ala
145                 150                 155                 160 
Ser His Arg Ala Leu Asp Asp Ile Ser Glu Ser Ile Lys Glu Leu Gln
                165                 170                 175     
Phe Tyr Arg Asn Asn Ile Phe Lys Lys Lys Ile Asp Glu Lys Lys Arg
            180                 185                 190         
Lys Ile Ile Glu Asn Gly Glu Asn Glu Lys Thr Val Ser
        195                 200                 205 


<210> 656
<211> 412
<212> PRT
<213> Homo sapiens

<400> 656
Met Ile Leu Ala Ser Val Leu Arg Ser Gly Pro Gly Gly Gly Leu Pro
 1               5                  10                  15      
Leu Arg Pro Leu Leu Gly Pro Ala Leu Ala Leu Arg Ala Arg Ser Thr
            20                  25                  30          
Ser Ala Thr Asp Thr His His Val Glu Met Ala Arg Glu Arg Ser Lys
        35                  40                  45              
Thr Val Thr Ser Phe Tyr Asn Gln Ser Ala Ile Asp Ala Ala Ala Glu
    50                  55                  60                  
Lys Pro Ser Val Arg Leu Thr Pro Thr Met Met Leu Tyr Ala Gly Arg
65                  70                  75                  80  
Ser Gln Asp Gly Ser His Leu Leu Lys Ser Ala Arg Tyr Leu Gln Gln
                85                  90                  95      
Glu Leu Pro Val Arg Ile Ala His Arg Ile Lys Gly Phe Arg Cys Leu
            100                 105                 110         
Pro Phe Ile Ile Gly Cys Asn Pro Thr Ile Leu His Val His Glu Leu
        115                 120                 125             
Tyr Ile Arg Ala Phe Gln Lys Leu Thr Asp Phe Pro Pro Ile Lys Asp
    130                 135                 140                 
Gln Ala Asp Glu Ala Gln Tyr Cys Gln Leu Val Arg Gln Leu Leu Asp
145                 150                 155                 160 
Asp His Lys Asp Val Val Thr Leu Leu Ala Glu Gly Leu Arg Glu Ser
                165                 170                 175     
Arg Lys His Ile Glu Asp Glu Lys Leu Val Arg Tyr Phe Leu Asp Lys
            180                 185                 190         
Thr Leu Thr Ser Arg Leu Gly Ile Arg Met Leu Ala Thr His His Leu
        195                 200                 205             
Ala Leu His Glu Asp Lys Pro Asp Phe Phe Gly Ile Ile Cys Thr Arg
    210                 215                 220                 
Leu Ser Pro Lys Lys Ile Ile Glu Lys Trp Val Asp Phe Ala Arg Arg
225                 230                 235                 240 
Leu Cys Glu His Lys Tyr Gly Asn Ala Pro Arg Val Arg Ile Asn Gly
                245                 250                 255     
His Val Ala Ala Arg Phe Pro Phe Ile Pro Met Pro Leu Asp Tyr Ile
            260                 265                 270         
Leu Pro Glu Leu Leu Lys Asn Ala Met Arg Ala Thr Met Glu Ser His
        275                 280                 285             
Leu Asp Thr Pro Tyr Asn Val Pro Asp Val Val Ile Thr Ile Ala Asn
    290                 295                 300                 
Asn Asp Val Asp Leu Ile Ile Arg Ile Ser Asp Arg Gly Gly Gly Ile
305                 310                 315                 320 
Ala His Lys Asp Leu Asp Arg Val Met Asp Tyr His Phe Thr Thr Ala
                325                 330                 335     
Glu Ala Ser Thr Gln Asp Pro Arg Ile Ser Pro Leu Phe Gly His Leu
            340                 345                 350         
Asp Met His Ser Gly Ala Gln Ser Gly Pro Met His Gly Phe Gly Phe
        355                 360                 365             
Gly Leu Pro Thr Ser Arg Ala Tyr Ala Glu Tyr Leu Gly Gly Ser Leu
    370                 375                 380                 
Gln Leu Gln Ser Leu Gln Gly Ile Gly Thr Asp Val Tyr Leu Arg Leu
385                 390                 395                 400 
Arg His Ile Asp Gly Arg Glu Glu Ser Phe Arg Ile
                405                 410         


<210> 657
<211> 478
<212> PRT
<213> Homo sapiens

<400> 657
Met Gly Arg Cys Cys Phe Tyr Thr Ala Gly Thr Leu Ser Leu Leu Leu
 1               5                  10                  15      
Leu Val Thr Ser Val Thr Leu Leu Val Ala Arg Val Phe Gln Lys Ala
            20                  25                  30          
Val Asp Gln Ser Ile Glu Lys Lys Ile Val Leu Arg Asn Gly Thr Glu
        35                  40                  45              
Ala Phe Asp Ser Trp Glu Lys Pro Pro Leu Pro Val Tyr Thr Gln Phe
    50                  55                  60                  
Tyr Phe Phe Asn Val Thr Asn Pro Glu Glu Ile Leu Arg Gly Glu Thr
65                  70                  75                  80  
Pro Arg Val Glu Glu Val Gly Pro Tyr Thr Tyr Arg Glu Leu Arg Asn
                85                  90                  95      
Lys Ala Asn Ile Gln Phe Gly Asp Asn Gly Thr Thr Ile Ser Ala Val
            100                 105                 110         
Ser Asn Lys Ala Tyr Val Phe Glu Arg Asp Gln Ser Val Gly Asp Pro
        115                 120                 125             
Lys Ile Asp Leu Ile Arg Thr Leu Asn Ile Pro Val Leu Thr Val Ile
    130                 135                 140                 
Glu Trp Ser Gln Val His Phe Leu Arg Glu Ile Ile Glu Ala Met Leu
145                 150                 155                 160 
Lys Ala Tyr Gln Gln Lys Leu Phe Val Thr His Thr Val Asp Glu Leu
                165                 170                 175     
Leu Trp Gly Tyr Lys Asp Glu Ile Leu Ser Leu Ile His Val Phe Arg
            180                 185                 190         
Pro Asp Ile Ser Pro Tyr Phe Gly Leu Phe Tyr Glu Lys Asn Gly Thr
        195                 200                 205             
Asn Asp Gly Asp Tyr Val Phe Leu Thr Gly Glu Asp Ser Tyr Leu Asn
    210                 215                 220                 
Phe Thr Lys Ile Val Glu Trp Asn Gly Lys Thr Ser Leu Asp Trp Trp
225                 230                 235                 240 
Ile Thr Asp Lys Cys Asn Met Ile Asn Gly Thr Asp Gly Asp Ser Phe
                245                 250                 255     
His Pro Leu Ile Thr Lys Asp Glu Val Leu Tyr Val Phe Pro Ser Asp
            260                 265                 270         
Phe Cys Arg Ser Val Tyr Ile Thr Phe Ser Asp Tyr Glu Ser Val Gln
        275                 280                 285             
Gly Leu Pro Ala Phe Arg Tyr Lys Val Pro Ala Glu Ile Leu Ala Asn
    290                 295                 300                 
Thr Ser Asp Asn Ala Gly Phe Cys Ile Pro Glu Gly Asn Cys Leu Gly
305                 310                 315                 320 
Ser Gly Val Leu Asn Val Ser Ile Cys Lys Asn Gly Ala Pro Ile Ile
                325                 330                 335     
Met Ser Phe Pro His Phe Tyr Gln Ala Asp Glu Arg Phe Val Ser Ala
            340                 345                 350         
Ile Glu Gly Met His Pro Asn Gln Glu Asp His Glu Thr Phe Val Asp
        355                 360                 365             
Ile Asn Pro Leu Thr Gly Ile Ile Leu Lys Ala Ala Lys Arg Phe Gln
    370                 375                 380                 
Ile Asn Ile Tyr Val Lys Lys Leu Asp Asp Phe Val Glu Thr Gly Asp
385                 390                 395                 400 
Ile Arg Thr Met Val Phe Pro Val Met Tyr Leu Asn Glu Ser Val His
                405                 410                 415     
Ile Asp Lys Glu Thr Ala Ser Arg Leu Lys Ser Met Ile Asn Thr Thr
            420                 425                 430         
Leu Ile Ile Thr Asn Ile Pro Tyr Ile Ile Met Ala Leu Gly Val Phe
        435                 440                 445             
Phe Gly Leu Val Phe Thr Trp Leu Ala Cys Lys Gly Gln Gly Ser Met
    450                 455                 460                 
Asp Glu Gly Thr Ala Asp Glu Arg Ala Pro Leu Ile Arg Thr
465                 470                 475             


<210> 658
<211> 268
<212> PRT
<213> Homo sapiens

<400> 658
Met Ala Ala Val Arg Ala Leu Val Ala Ser Arg Leu Ala Ala Ala Ser
 1               5                  10                  15      
Ala Phe Thr Ser Leu Ser Pro Gly Gly Arg Thr Pro Ser Gln Arg Ala
            20                  25                  30          
Ala Leu His Leu Ser Val Pro Arg Pro Ala Ala Arg Val Ala Leu Val
        35                  40                  45              
Leu Ser Gly Cys Gly Val Tyr Asp Gly Thr Glu Ile His Glu Ala Ser
    50                  55                  60                  
Ala Ile Leu Val His Leu Ser Arg Gly Gly Ala Glu Val Gln Ile Phe
65                  70                  75                  80  
Ala Pro Asp Val Pro Gln Met His Val Ile Asp His Thr Lys Gly Gln
                85                  90                  95      
Pro Ser Glu Gly Glu Ser Arg Asn Val Leu Thr Glu Ser Ala Arg Ile
            100                 105                 110         
Ala Arg Gly Lys Ile Thr Asp Leu Ala Asn Leu Ser Ala Ala Asn His
        115                 120                 125             
Asp Ala Ala Ile Phe Pro Gly Gly Phe Gly Ala Ala Lys Asn Leu Ser
    130                 135                 140                 
Thr Phe Ala Val Asp Gly Lys Asp Cys Lys Val Asn Lys Glu Val Glu
145                 150                 155                 160 
Arg Val Leu Lys Glu Phe His Gln Ala Gly Lys Pro Ile Gly Leu Cys
                165                 170                 175     
Cys Ile Ala Pro Val Leu Ala Ala Lys Val Leu Arg Gly Val Glu Val
            180                 185                 190         
Thr Val Gly His Glu Gln Glu Glu Gly Gly Lys Trp Pro Tyr Ala Gly
        195                 200                 205             
Thr Ala Glu Ala Ile Lys Ala Leu Gly Ala Lys His Cys Val Lys Glu
    210                 215                 220                 
Val Val Glu Ala His Val Asp Gln Lys Asn Lys Val Val Thr Thr Pro
225                 230                 235                 240 
Ala Phe Met Cys Glu Thr Ala Leu His Tyr Ile His Asp Gly Ile Gly
                245                 250                 255     
Ala Met Val Arg Lys Val Leu Glu Leu Thr Gly Lys
            260                 265             


<210> 659
<211> 662
<212> PRT
<213> Homo sapiens

<400> 659
Met Arg Pro Gln Ile Leu Leu Leu Leu Ala Leu Leu Thr Leu Gly Leu
 1               5                  10                  15      
Ala Ala Gln His Gln Asp Lys Val Pro Cys Lys Met Val Asp Lys Lys
            20                  25                  30          
Val Ser Cys Gln Val Leu Gly Leu Leu Gln Val Pro Ser Val Leu Pro
        35                  40                  45              
Pro Asp Thr Glu Thr Leu Asp Leu Ser Gly Asn Gln Leu Arg Ser Ile
    50                  55                  60                  
Leu Ala Ser Pro Leu Gly Phe Tyr Thr Ala Leu Arg His Leu Asp Leu
65                  70                  75                  80  
Ser Thr Asn Glu Ile Ser Phe Leu Gln Pro Gly Ala Phe Gln Ala Leu
                85                  90                  95      
Thr His Leu Glu His Leu Ser Leu Ala His Asn Arg Leu Ala Met Ala
            100                 105                 110         
Thr Ala Leu Ser Ala Gly Gly Leu Gly Pro Leu Pro Arg Val Thr Ser
        115                 120                 125             
Leu Asp Leu Ser Gly Asn Ser Leu Tyr Ser Gly Leu Leu Glu Arg Leu
    130                 135                 140                 
Leu Gly Glu Ala Pro Ser Leu His Thr Leu Ser Leu Ala Glu Asn Ser
145                 150                 155                 160 
Leu Thr Arg Leu Thr Arg His Thr Phe Arg Asp Met Pro Ala Leu Glu
                165                 170                 175     
Gln Leu Asp Leu His Ser Asn Val Leu Met Asp Ile Glu Asp Gly Ala
            180                 185                 190         
Phe Glu Gly Leu Pro Arg Leu Thr His Leu Asn Leu Ser Arg Asn Ser
        195                 200                 205             
Leu Thr Cys Ile Ser Asp Phe Ser Leu Gln Gln Leu Arg Val Leu Asp
    210                 215                 220                 
Leu Ser Cys Asn Ser Ile Glu Ala Phe Gln Thr Ala Ser Gln Pro Gln
225                 230                 235                 240 
Ala Glu Phe Gln Leu Thr Trp Leu Asp Leu Arg Glu Asn Lys Leu Leu
                245                 250                 255     
His Phe Pro Asp Leu Ala Ala Leu Pro Arg Leu Ile Tyr Leu Asn Leu
            260                 265                 270         
Ser Asn Asn Leu Ile Arg Leu Pro Thr Gly Pro Pro Gln Asp Ser Lys
        275                 280                 285             
Gly Ile His Ala Pro Ser Glu Gly Trp Ser Ala Leu Pro Leu Ser Ala
    290                 295                 300                 
Pro Ser Gly Asn Ala Ser Gly Arg Pro Leu Ser Gln Leu Leu Asn Leu
305                 310                 315                 320 
Asp Leu Ser Tyr Asn Glu Ile Glu Leu Ile Pro Asp Ser Phe Leu Glu
                325                 330                 335     
His Leu Thr Ser Leu Cys Phe Leu Asn Leu Ser Arg Asn Cys Leu Arg
            340                 345                 350         
Thr Phe Glu Ala Arg Arg Leu Gly Ser Leu Pro Cys Leu Met Leu Leu
        355                 360                 365             
Asp Leu Ser His Asn Ala Leu Glu Thr Leu Glu Leu Gly Ala Arg Ala
    370                 375                 380                 
Leu Gly Ser Leu Arg Thr Leu Leu Leu Gln Gly Asn Ala Leu Arg Asp
385                 390                 395                 400 
Leu Pro Pro Tyr Thr Phe Ala Asn Leu Ala Ser Leu Gln Arg Leu Asn
                405                 410                 415     
Leu Gln Gly Asn Arg Val Ser Pro Cys Gly Gly Pro Asp Glu Pro Gly
            420                 425                 430         
Pro Ser Gly Cys Val Ala Phe Ser Gly Ile Thr Ser Leu Arg Ser Leu
        435                 440                 445             
Ser Leu Val Asp Asn Glu Ile Glu Leu Leu Arg Ala Gly Ala Phe Leu
    450                 455                 460                 
His Thr Pro Leu Thr Glu Leu Asp Leu Ser Ser Asn Pro Gly Leu Glu
465                 470                 475                 480 
Val Ala Thr Gly Ala Leu Gly Gly Leu Glu Ala Ser Leu Glu Val Leu
                485                 490                 495     
Ala Leu Gln Gly Asn Gly Leu Met Val Leu Gln Val Asp Leu Pro Cys
            500                 505                 510         
Phe Ile Cys Leu Lys Arg Leu Asn Leu Ala Glu Asn Arg Leu Ser His
        515                 520                 525             
Leu Pro Ala Trp Thr Gln Ala Val Ser Leu Glu Val Leu Asp Leu Arg
    530                 535                 540                 
Asn Asn Ser Phe Ser Leu Leu Pro Gly Ser Ala Met Gly Gly Leu Glu
545                 550                 555                 560 
Thr Ser Leu Arg Arg Leu Tyr Leu Gln Gly Asn Pro Leu Ser Cys Cys
                565                 570                 575     
Gly Asn Gly Trp Leu Ala Ala Gln Leu His Gln Gly Arg Val Asp Val
            580                 585                 590         
Asp Ala Thr Gln Asp Leu Ile Cys Arg Phe Ser Ser Gln Glu Glu Val
        595                 600                 605             
Ser Leu Ser His Val Arg Pro Glu Asp Cys Glu Lys Gly Gly Leu Lys
    610                 615                 620                 
Asn Ile Asn Leu Ile Ile Ile Leu Thr Phe Ile Leu Val Ser Ala Ile
625                 630                 635                 640 
Leu Leu Thr Thr Leu Ala Ala Cys Cys Cys Val Arg Arg Gln Lys Phe
                645                 650                 655     
Asn Gln Gln Tyr Lys Ala
            660         


<210> 660
<211> 366
<212> PRT
<213> Homo sapiens

<400> 660
Met Ala Gly Pro Ala Trp Ile Ser Lys Val Ser Arg Leu Leu Gly Ala
 1               5                  10                  15      
Phe His Asn Pro Lys Gln Val Thr Arg Gly Phe Thr Gly Gly Val Gln
            20                  25                  30          
Thr Val Thr Leu Ile Pro Gly Asp Gly Ile Gly Pro Glu Ile Ser Ala
        35                  40                  45              
Ala Val Met Lys Ile Phe Asp Ala Ala Lys Ala Pro Ile Gln Trp Glu
    50                  55                  60                  
Glu Arg Asn Val Thr Ala Ile Gln Gly Pro Gly Gly Lys Trp Met Ile
65                  70                  75                  80  
Pro Ser Glu Ala Lys Glu Ser Met Asp Lys Asn Lys Met Gly Leu Lys
                85                  90                  95      
Gly Pro Leu Lys Thr Pro Ile Ala Ala Gly His Pro Ser Met Asn Leu
            100                 105                 110         
Leu Leu Arg Lys Thr Phe Asp Leu Tyr Ala Asn Val Arg Pro Cys Val
        115                 120                 125             
Ser Ile Glu Gly Tyr Lys Thr Pro Tyr Thr Asp Val Asn Ile Val Thr
    130                 135                 140                 
Ile Arg Glu Asn Thr Glu Gly Glu Tyr Ser Gly Ile Glu His Val Ile
145                 150                 155                 160 
Val Asp Gly Val Val Gln Ser Ile Lys Leu Ile Thr Glu Gly Ala Ser
                165                 170                 175     
Lys Arg Ile Ala Glu Phe Ala Phe Glu Tyr Ala Arg Asn Asn His Arg
            180                 185                 190         
Ser Asn Val Thr Ala Val His Lys Ala Asn Ile Met Arg Met Ser Asp
        195                 200                 205             
Gly Leu Phe Leu Gln Lys Cys Arg Glu Val Ala Glu Ser Cys Lys Asp
    210                 215                 220                 
Ile Lys Phe Asn Glu Met Tyr Leu Asp Thr Val Cys Leu Asn Met Val
225                 230                 235                 240 
Gln Asp Pro Ser Gln Phe Asp Val Leu Val Met Pro Asn Leu Tyr Gly
                245                 250                 255     
Asp Ile Leu Ser Asp Leu Cys Ala Gly Leu Ile Gly Gly Leu Gly Val
            260                 265                 270         
Thr Pro Ser Gly Asn Ile Gly Ala Asn Gly Val Ala Ile Phe Glu Ser
        275                 280                 285             
Val His Gly Thr Ala Pro Asp Ile Ala Gly Lys Asp Met Ala Asn Pro
    290                 295                 300                 
Thr Ala Leu Leu Leu Ser Ala Val Met Met Leu Arg His Met Gly Leu
305                 310                 315                 320 
Phe Asp His Ala Ala Arg Ile Glu Ala Ala Cys Phe Ala Thr Ile Lys
                325                 330                 335     
Asp Gly Lys Ser Leu Thr Lys Asp Leu Gly Gly Asn Ala Lys Cys Ser
            340                 345                 350         
Asp Phe Thr Glu Glu Ile Cys Arg Arg Val Lys Asp Leu Asp
        355                 360                 365     


<210> 661
<211> 366
<212> PRT
<213> Homo sapiens

<400> 661
Met Ala Gly Pro Ala Trp Ile Ser Lys Val Ser Arg Leu Leu Gly Ala
 1               5                  10                  15      
Phe His Asn Pro Lys Gln Val Thr Arg Gly Phe Thr Gly Gly Val Gln
            20                  25                  30          
Thr Val Thr Leu Ile Pro Gly Asp Gly Ile Gly Pro Glu Ile Ser Ala
        35                  40                  45              
Ala Val Met Lys Ile Phe Asp Ala Ala Lys Ala Pro Ile Gln Trp Glu
    50                  55                  60                  
Glu Arg Asn Val Thr Ala Ile Gln Gly Pro Gly Gly Lys Trp Met Ile
65                  70                  75                  80  
Pro Ser Glu Ala Lys Glu Ser Met Asp Lys Asn Lys Met Gly Leu Lys
                85                  90                  95      
Gly Pro Leu Lys Thr Pro Ile Ala Ala Gly His Pro Ser Met Asn Leu
            100                 105                 110         
Leu Leu Arg Lys Thr Phe Asp Leu Tyr Ala Asn Val Arg Pro Cys Val
        115                 120                 125             
Ser Ile Glu Gly Tyr Lys Thr Pro Tyr Thr Asp Val Asn Ile Val Thr
    130                 135                 140                 
Ile Arg Glu Asn Thr Glu Gly Glu Tyr Ser Gly Ile Glu His Val Ile
145                 150                 155                 160 
Val Asp Gly Val Val Gln Ser Ile Lys Leu Ile Thr Glu Gly Ala Ser
                165                 170                 175     
Lys Arg Ile Ala Glu Phe Ala Phe Glu Tyr Ala Arg Asn Asn His Arg
            180                 185                 190         
Ser Asn Val Thr Ala Val His Lys Ala Asn Ile Met Arg Met Ser Asp
        195                 200                 205             
Gly Leu Phe Leu Gln Lys Cys Arg Glu Val Ala Glu Ser Cys Lys Asp
    210                 215                 220                 
Ile Lys Phe Asn Glu Met Tyr Leu Asp Thr Val Cys Leu Asn Met Val
225                 230                 235                 240 
Gln Asp Pro Ser Gln Phe Asp Val Leu Val Met Pro Asn Leu Tyr Gly
                245                 250                 255     
Asp Ile Leu Ser Asp Leu Cys Ala Gly Leu Ile Gly Gly Leu Gly Val
            260                 265                 270         
Thr Pro Ser Gly Asn Ile Gly Ala Asn Gly Val Ala Ile Phe Glu Ser
        275                 280                 285             
Val His Gly Thr Ala Pro Asp Ile Ala Gly Lys Asp Met Ala Asn Pro
    290                 295                 300                 
Thr Ala Leu Leu Leu Ser Ala Val Met Met Leu Arg His Met Gly Leu
305                 310                 315                 320 
Phe Asp His Ala Ala Arg Ile Glu Ala Ala Cys Phe Ala Thr Ile Lys
                325                 330                 335     
Asp Gly Lys Ser Leu Thr Lys Asp Leu Gly Gly Asn Ala Lys Cys Ser
            340                 345                 350         
Asp Phe Thr Glu Glu Ile Cys Arg Arg Val Lys Asp Leu Asp
        355                 360                 365     


<210> 662
<211> 572
<212> PRT
<213> Homo sapiens

<400> 662
Met Glu Thr Pro Ser Gln Arg Arg Ala Thr Arg Ser Gly Ala Gln Ala
 1               5                  10                  15      
Ser Ser Thr Pro Leu Ser Pro Thr Arg Ile Thr Arg Leu Gln Glu Lys
            20                  25                  30          
Glu Asp Leu Gln Glu Leu Asn Asp Arg Leu Ala Val Tyr Ile Asp Arg
        35                  40                  45              
Val Arg Ser Leu Glu Thr Glu Asn Ala Gly Leu Arg Leu Arg Ile Thr
    50                  55                  60                  
Glu Ser Glu Glu Val Val Ser Arg Glu Val Ser Gly Ile Lys Ala Ala
65                  70                  75                  80  
Tyr Glu Ala Glu Leu Gly Asp Ala Arg Lys Thr Leu Asp Ser Val Ala
                85                  90                  95      
Lys Glu Arg Ala Arg Leu Gln Leu Glu Leu Ser Lys Val Arg Glu Glu
            100                 105                 110         
Phe Lys Glu Leu Lys Ala Arg Asn Thr Lys Lys Glu Gly Asp Leu Ile
        115                 120                 125             
Ala Ala Gln Ala Arg Leu Lys Asp Leu Glu Ala Leu Leu Asn Ser Lys
    130                 135                 140                 
Glu Ala Ala Leu Ser Thr Ala Leu Ser Glu Lys Arg Thr Leu Glu Gly
145                 150                 155                 160 
Glu Leu His Asp Leu Arg Gly Gln Val Ala Lys Leu Glu Ala Ala Leu
                165                 170                 175     
Gly Glu Ala Lys Lys Gln Leu Gln Asp Glu Met Leu Arg Arg Val Asp
            180                 185                 190         
Ala Glu Asn Arg Leu Gln Thr Met Lys Glu Glu Leu Asp Phe Gln Lys
        195                 200                 205             
Asn Ile Tyr Ser Glu Glu Leu Arg Glu Thr Lys Arg Arg His Glu Thr
    210                 215                 220                 
Arg Leu Val Glu Ile Asp Asn Gly Lys Gln Arg Glu Phe Glu Ser Arg
225                 230                 235                 240 
Leu Ala Asp Ala Leu Gln Glu Leu Arg Ala Gln His Glu Asp Gln Val
                245                 250                 255     
Glu Gln Tyr Lys Lys Glu Leu Glu Lys Thr Tyr Ser Ala Lys Leu Asp
            260                 265                 270         
Asn Ala Arg Gln Ser Ala Glu Arg Asn Ser Asn Leu Val Gly Ala Ala
        275                 280                 285             
His Glu Glu Leu Gln Gln Ser Arg Ile Arg Ile Asp Ser Leu Ser Ala
    290                 295                 300                 
Gln Leu Ser Gln Leu Gln Lys Gln Leu Ala Ala Lys Glu Ala Lys Leu
305                 310                 315                 320 
Arg Asp Leu Glu Asp Ser Leu Ala Arg Glu Arg Asp Thr Ser Arg Arg
                325                 330                 335     
Leu Leu Ala Glu Lys Glu Arg Glu Met Ala Glu Met Arg Ala Arg Met
            340                 345                 350         
Gln Gln Gln Leu Asp Glu Tyr Gln Glu Leu Leu Asp Ile Lys Leu Ala
        355                 360                 365             
Leu Asp Met Glu Ile His Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu
    370                 375                 380                 
Glu Arg Leu Arg Leu Ser Pro Ser Pro Thr Ser Gln Arg Ser Arg Gly
385                 390                 395                 400 
Arg Ala Ser Ser His Ser Ser Gln Thr Gln Gly Gly Gly Ser Val Thr
                405                 410                 415     
Lys Lys Arg Lys Leu Glu Ser Thr Glu Ser Arg Ser Ser Phe Ser Gln
            420                 425                 430         
His Ala Arg Thr Ser Gly Arg Val Ala Val Glu Glu Val Asp Glu Glu
        435                 440                 445             
Gly Lys Phe Val Arg Leu Arg Asn Lys Ser Asn Glu Asp Gln Ser Met
    450                 455                 460                 
Gly Asn Trp Gln Ile Lys Arg Gln Asn Gly Asp Asp Pro Leu Leu Thr
465                 470                 475                 480 
Tyr Arg Phe Pro Pro Lys Phe Thr Leu Lys Ala Gly Gln Val Val Thr
                485                 490                 495     
Ile Trp Ala Ala Gly Ala Gly Ala Thr His Ser Pro Pro Thr Asp Leu
            500                 505                 510         
Val Trp Lys Ala Gln Asn Thr Trp Gly Cys Gly Asn Ser Leu Arg Thr
        515                 520                 525             
Ala Leu Ile Asn Ser Thr Gly Glu Glu Val Ala Met Arg Lys Leu Val
    530                 535                 540                 
Arg Ser Val Thr Val Val Glu Asp Asp Glu Asp Glu Asp Gly Asp Asp
545                 550                 555                 560 
Leu Leu His His His His Val Ser Gly Ser Arg Arg
                565                 570         


<210> 663
<211> 1025
<212> PRT
<213> Homo sapiens

<400> 663
Met Glu Pro Phe Thr Asn Asp Arg Leu Gln Leu Pro Arg Asn Met Ile
 1               5                  10                  15      
Glu Asn Ser Met Phe Glu Glu Glu Pro Asp Val Val Asp Leu Ala Lys
            20                  25                  30          
Glu Pro Cys Leu His Pro Leu Glu Pro Asp Glu Val Glu Tyr Glu Pro
        35                  40                  45              
Arg Gly Ser Arg Leu Leu Val Arg Gly Leu Gly Glu His Glu Met Glu
    50                  55                  60                  
Glu Asp Glu Glu Asp Tyr Glu Ser Ser Ala Lys Leu Leu Gly Met Ser
65                  70                  75                  80  
Phe Met Asn Arg Ser Ser Gly Leu Arg Asn Ser Ala Thr Gly Tyr Arg
                85                  90                  95      
Gln Ser Pro Asp Gly Ala Cys Ser Val Pro Ser Ala Arg Thr Met Val
            100                 105                 110         
Val Cys Ala Phe Val Ile Val Val Ala Val Ser Val Ile Met Val Ile
        115                 120                 125             
Tyr Leu Leu Pro Arg Cys Thr Phe Thr Lys Glu Gly Cys His Lys Lys
    130                 135                 140                 
Asn Gln Ser Ile Gly Leu Ile Gln Pro Phe Ala Thr Asn Gly Lys Leu
145                 150                 155                 160 
Phe Pro Trp Ala Gln Ile Arg Leu Pro Thr Ala Val Val Pro Leu Arg
                165                 170                 175     
Tyr Glu Leu Ser Leu His Pro Asn Leu Thr Ser Met Thr Phe Arg Gly
            180                 185                 190         
Ser Val Thr Ile Ser Val Gln Ala Leu Gln Val Thr Trp Asn Ile Ile
        195                 200                 205             
Leu His Ser Thr Gly His Asn Ile Ser Arg Val Thr Phe Met Ser Ala
    210                 215                 220                 
Val Ser Ser Gln Glu Lys Gln Ala Glu Ile Leu Glu Tyr Ala Tyr His
225                 230                 235                 240 
Gly Gln Ile Ala Ile Val Ala Pro Glu Ala Leu Leu Ala Gly His Asn
                245                 250                 255     
Tyr Thr Leu Lys Ile Glu Tyr Ser Ala Asn Ile Ser Ser Ser Tyr Tyr
            260                 265                 270         
Gly Phe Tyr Gly Phe Ser Tyr Thr Asp Glu Ser Asn Glu Lys Lys Tyr
        275                 280                 285             
Phe Ala Ala Thr Gln Phe Glu Pro Leu Ala Ala Arg Ser Ala Phe Pro
    290                 295                 300                 
Cys Phe Asp Glu Pro Ala Phe Lys Ala Thr Phe Ile Ile Lys Ile Ile
305                 310                 315                 320 
Arg Asp Glu Gln Tyr Thr Ala Leu Ser Asn Met Pro Lys Lys Ser Ser
                325                 330                 335     
Val Val Leu Asp Asp Gly Leu Val Gln Asp Glu Phe Ser Glu Ser Val
            340                 345                 350         
Lys Met Ser Thr Tyr Leu Val Ala Phe Ile Val Gly Glu Met Lys Asn
        355                 360                 365             
Leu Ser Gln Asp Val Asn Gly Thr Leu Val Ser Ile Tyr Ala Val Pro
    370                 375                 380                 
Glu Asn Ile Gly Gln Val His Tyr Ala Leu Glu Thr Thr Val Lys Leu
385                 390                 395                 400 
Leu Glu Phe Phe Gln Asn Tyr Phe Glu Ile Gln Tyr Pro Leu Lys Lys
                405                 410                 415     
Leu Asp Leu Val Ala Ile Pro Asp Phe Glu Ala Gly Ala Met Glu Asn
            420                 425                 430         
Trp Gly Leu Leu Thr Phe Arg Glu Glu Thr Leu Leu Tyr Asp Ser Asn
        435                 440                 445             
Thr Ser Ser Met Ala Asp Arg Lys Leu Val Thr Lys Ile Ile Ala His
    450                 455                 460                 
Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr Met Lys Trp Trp
465                 470                 475                 480 
Asn Asp Leu Trp Leu Asn Glu Gly Phe Ala Thr Phe Met Glu Tyr Phe
                485                 490                 495     
Ser Leu Glu Lys Ile Phe Lys Glu Leu Ser Ser Tyr Glu Asp Phe Leu
            500                 505                 510         
Asp Ala Arg Phe Lys Thr Met Lys Lys Asp Ser Leu Asn Ser Ser His
        515                 520                 525             
Pro Ile Ser Ser Ser Val Gln Ser Ser Glu Gln Ile Glu Glu Met Phe
    530                 535                 540                 
Asp Ser Leu Ser Tyr Phe Lys Gly Ser Ser Leu Leu Leu Met Leu Lys
545                 550                 555                 560 
Thr Tyr Leu Ser Glu Asp Val Phe Gln His Ala Val Val Leu Tyr Leu
                565                 570                 575     
His Asn His Ser Tyr Ala Ser Ile Gln Ser Asp Asp Leu Trp Asp Ser
            580                 585                 590         
Phe Asn Glu Val Thr Asn Gln Thr Leu Asp Val Lys Arg Met Met Lys
        595                 600                 605             
Thr Trp Thr Leu Gln Lys Gly Phe Pro Leu Val Thr Val Gln Lys Lys
    610                 615                 620                 
Gly Lys Glu Leu Phe Ile Gln Gln Glu Arg Phe Phe Leu Asn Met Lys
625                 630                 635                 640 
Pro Glu Ile Gln Pro Ser Asp Thr Ser Tyr Leu Trp His Ile Pro Leu
                645                 650                 655     
Ser Tyr Val Thr Glu Gly Arg Asn Tyr Ser Lys Tyr Gln Ser Val Ser
            660                 665                 670         
Leu Leu Asp Lys Lys Ser Gly Val Ile Asn Leu Thr Glu Glu Val Leu
        675                 680                 685             
Trp Val Lys Val Asn Ile Asn Met Asn Gly Tyr Tyr Ile Val His Tyr
    690                 695                 700                 
Ala Asp Asp Asp Trp Glu Ala Leu Ile His Gln Leu Lys Ile Asn Pro
705                 710                 715                 720 
Tyr Val Leu Ser Asp Lys Asp Arg Ala Asn Leu Ile Asn Asn Ile Phe
                725                 730                 735     
Glu Leu Ala Gly Leu Gly Lys Val Pro Leu Lys Arg Ala Phe Asp Leu
            740                 745                 750         
Ile Asn Tyr Leu Gly Asn Glu Asn His Thr Ala Pro Ile Thr Glu Ala
        755                 760                 765             
Leu Phe Gln Thr Asp Leu Ile Tyr Asn Leu Leu Glu Lys Leu Gly Tyr
    770                 775                 780                 
Met Asp Leu Ala Ser Arg Leu Val Thr Arg Val Phe Lys Leu Leu Gln
785                 790                 795                 800 
Asn Gln Ile Gln Gln Gln Thr Trp Thr Asp Glu Gly Thr Pro Ser Met
                805                 810                 815     
Arg Glu Leu Arg Ser Ala Leu Leu Glu Phe Ala Cys Thr His Asn Leu
            820                 825                 830         
Gly Asn Cys Ser Thr Thr Ala Met Lys Leu Phe Asp Asp Trp Met Ala
        835                 840                 845             
Ser Asn Gly Thr Gln Ser Leu Pro Thr Asp Val Met Thr Thr Val Phe
    850                 855                 860                 
Lys Val Gly Ala Lys Thr Asp Lys Gly Trp Ser Phe Leu Leu Gly Lys
865                 870                 875                 880 
Tyr Ile Ser Ile Gly Ser Glu Ala Glu Lys Asn Lys Ile Leu Glu Ala
                885                 890                 895     
Leu Ala Ser Ser Glu Asp Val Arg Lys Leu Tyr Trp Leu Met Lys Ser
            900                 905                 910         
Ser Leu Asn Gly Asp Asn Phe Arg Thr Gln Lys Leu Ser Phe Ile Ile
        915                 920                 925             
Arg Thr Val Gly Arg His Phe Pro Gly His Leu Leu Ala Trp Asp Phe
    930                 935                 940                 
Val Lys Glu Asn Trp Asn Lys Leu Val Gln Lys Phe Pro Leu Gly Ser
945                 950                 955                 960 
Tyr Thr Ile Gln Asn Ile Val Ala Gly Ser Thr Tyr Leu Phe Ser Thr
                965                 970                 975     
Lys Thr His Leu Ser Glu Val Gln Ala Phe Phe Glu Asn Gln Ser Glu
            980                 985                 990         
Ala Thr Phe Arg Leu Arg Cys Val Gln Glu Ala Leu Glu Val Ile Gln
        995                 1000                1005            
Leu Asn Ile Gln Trp Met Glu Lys Asn Leu Lys Ser Leu Thr Trp Trp
    1010                1015                1020                
Leu
1025


<210> 664
<211> 133
<212> PRT
<213> Homo sapiens

<400> 664
Met Met Leu Asn Ser Asp Thr Met Glu Leu Asp Leu Pro Pro Thr His
 1               5                  10                  15      
Ser Glu Thr Glu Ser Gly Phe Ser Asp Cys Gly Gly Gly Ala Gly Pro
            20                  25                  30          
Asp Gly Ala Gly Pro Gly Gly Pro Gly Gly Gly Gln Ala Arg Gly Pro
        35                  40                  45              
Glu Pro Gly Glu Pro Gly Arg Lys Asp Leu Gln His Leu Ser Arg Glu
    50                  55                  60                  
Glu Arg Arg Arg Arg Arg Arg Ala Thr Ala Lys Tyr Arg Thr Ala His
65                  70                  75                  80  
Ala Thr Arg Glu Arg Ile Arg Val Glu Ala Phe Asn Leu Ala Phe Ala
                85                  90                  95      
Glu Leu Arg Lys Leu Leu Pro Thr Leu Pro Pro Asp Lys Lys Leu Ser
            100                 105                 110         
Lys Ile Glu Ile Leu Arg Leu Ala Ile Cys Tyr Ile Ser Tyr Leu Asn
        115                 120                 125             
His Val Leu Asp Val
    130             


<210> 665
<211> 207
<212> PRT
<213> Homo sapiens

<400> 665
Met Leu Ala Leu Arg Cys Gly Ser Arg Trp Leu Gly Leu Leu Ser Val
 1               5                  10                  15      
Pro Arg Ser Val Pro Leu Arg Leu Pro Ala Ala Arg Ala Cys Ser Lys
            20                  25                  30          
Gly Ser Gly Asp Pro Ser Ser Ser Ser Ser Ser Gly Asn Pro Leu Val
        35                  40                  45              
Tyr Leu Asp Val Asp Ala Asn Gly Lys Pro Leu Gly Arg Val Val Leu
    50                  55                  60                  
Glu Leu Lys Ala Asp Val Val Pro Lys Thr Ala Glu Asn Phe Arg Ala
65                  70                  75                  80  
Leu Cys Thr Gly Glu Lys Gly Phe Gly Tyr Lys Gly Ser Thr Phe His
                85                  90                  95      
Arg Val Ile Pro Ser Phe Met Cys Gln Ala Gly Asp Phe Thr Asn His
            100                 105                 110         
Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly Ser Arg Phe Pro Asp Glu
        115                 120                 125             
Asn Phe Thr Leu Lys His Val Gly Pro Gly Val Leu Ser Met Ala Asn
    130                 135                 140                 
Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe Phe Ile Cys Thr Ile Lys
145                 150                 155                 160 
Thr Asp Trp Leu Asp Gly Lys His Val Val Phe Gly His Val Lys Glu
                165                 170                 175     
Gly Met Asp Val Val Lys Lys Ile Glu Ser Phe Gly Ser Lys Ser Gly
            180                 185                 190         
Arg Thr Ser Lys Lys Ile Val Ile Thr Asp Cys Gly Gln Leu Ser
        195                 200                 205         


<210> 666
<211> 1318
<212> PRT
<213> Homo sapiens

<400> 666
Met Leu Ile Phe Ser Val Arg Asp Met Phe Ala Lys Met Ser Ile Leu
 1               5                  10                  15      
Gly Val Arg Ser Phe Gly Ile Glu Asp Lys Asp Lys Gln Ile Ile Thr
            20                  25                  30          
Phe Phe Ser Pro Leu Thr Ile Leu Val Gly Pro Asn Gly Ala Gly Lys
        35                  40                  45              
Thr Thr Ile Ile Glu Cys Leu Lys Tyr Ile Cys Thr Gly Asp Phe Pro
    50                  55                  60                  
Pro Gly Thr Lys Gly Asn Thr Phe Val His Asp Pro Lys Val Ala Gln
65                  70                  75                  80  
Glu Thr Asp Val Arg Ala Gln Ile Arg Leu Gln Phe Arg Asp Val Asn
                85                  90                  95      
Gly Glu Leu Ile Ala Val Gln Arg Ser Met Val Cys Thr Gln Lys Ser
            100                 105                 110         
Lys Lys Thr Glu Phe Lys Thr Leu Glu Gly Val Ile Thr Arg Thr Lys
        115                 120                 125             
His Gly Glu Lys Val Ser Leu Ser Ser Lys Cys Ala Glu Ile Asp Arg
    130                 135                 140                 
Glu Met Ile Ser Ser Leu Gly Val Ser Lys Ala Val Leu Asn Asn Val
145                 150                 155                 160 
Ile Phe Cys His Gln Glu Asp Ser Asn Trp Pro Leu Ser Glu Gly Lys
                165                 170                 175     
Ala Leu Lys Gln Lys Phe Asp Glu Ile Phe Ser Ala Thr Arg Tyr Ile
            180                 185                 190         
Lys Ala Leu Glu Thr Leu Arg Gln Val Arg Gln Thr Gln Gly Gln Lys
        195                 200                 205             
Val Glu Glu Tyr Gln Met Glu Leu Lys Tyr Leu Lys Gln Tyr Lys Glu
    210                 215                 220                 
Lys Ala Cys Glu Ile Arg Asp Gln Ile Thr Ser Lys Glu Ala Gln Leu
225                 230                 235                 240 
Thr Ser Ser Lys Glu Ile Val Lys Ser Tyr Glu Asn Glu Leu Asp Pro
                245                 250                 255     
Leu Lys Asn Arg Leu Lys Glu Ile Glu His Asn Leu Ser Lys Ile Met
            260                 265                 270         
Lys Leu Asp Asn Glu Ile Lys Ala Leu Asp Ser Arg Lys Lys Gln Met
        275                 280                 285             
Glu Lys Asp Asn Ser Glu Leu Glu Glu Lys Met Glu Lys Val Phe Gln
    290                 295                 300                 
Gly Thr Asp Glu Gln Leu Asn Asp Leu Tyr His Asn His Gln Arg Thr
305                 310                 315                 320 
Val Arg Glu Lys Glu Arg Lys Leu Val Asp Cys His Arg Glu Leu Glu
                325                 330                 335     
Lys Leu Asn Lys Glu Ser Arg Leu Leu Asn Gln Glu Lys Ser Glu Leu
            340                 345                 350         
Leu Val Glu Gln Gly Arg Leu Gln Leu Gln Ala Asp Arg His Gln Glu
        355                 360                 365             
His Ile Arg Ala Arg Asp Ser Leu Ile Gln Ser Leu Ala Thr Gln Leu
    370                 375                 380                 
Glu Leu Asp Gly Phe Glu Arg Gly Pro Phe Ser Glu Arg Gln Ile Lys
385                 390                 395                 400 
Asn Phe His Lys Leu Val Arg Glu Arg Gln Glu Gly Glu Ala Lys Thr
                405                 410                 415     
Ala Asn Gln Leu Met Asn Asp Phe Ala Glu Lys Glu Thr Leu Lys Gln
            420                 425                 430         
Lys Gln Ile Asp Glu Ile Arg Asp Lys Lys Thr Gly Leu Gly Arg Ile
        435                 440                 445             
Ile Glu Leu Lys Ser Glu Ile Leu Ser Lys Lys Gln Asn Glu Leu Lys
    450                 455                 460                 
Asn Val Lys Tyr Glu Leu Gln Gln Leu Glu Gly Ser Ser Asp Arg Ile
465                 470                 475                 480 
Leu Glu Leu Asp Gln Glu Leu Ile Lys Ala Glu Arg Glu Leu Ser Lys
                485                 490                 495     
Ala Glu Lys Asn Ser Asn Val Glu Thr Leu Lys Met Glu Val Ile Ser
            500                 505                 510         
Leu Gln Asn Glu Lys Ala Asp Leu Asp Arg Thr Leu Arg Lys Leu Asp
        515                 520                 525             
Gln Glu Met Glu Gln Leu Asn His His Thr Thr Thr Arg Thr Gln Met
    530                 535                 540                 
Glu Met Leu Thr Lys Asp Lys Ala Asp Lys Asp Glu Gln Ile Arg Lys
545                 550                 555                 560 
Ile Lys Ser Arg His Ser Asp Glu Leu Thr Ser Leu Leu Gly Tyr Phe
                565                 570                 575     
Pro Asn Lys Lys Gln Leu Glu Asp Trp Leu His Ser Lys Ser Lys Glu
            580                 585                 590         
Ile Asn Gln Thr Arg Asp Arg Leu Ala Lys Leu Asn Lys Glu Leu Ala
        595                 600                 605             
Ser Ser Glu Gln Asn Lys Asn His Ile Asn Asn Glu Leu Glu Arg Lys
    610                 615                 620                 
Glu Glu Gln Leu Ser Ser Tyr Glu Asp Lys Leu Phe Asp Val Cys Gly
625                 630                 635                 640 
Ser Gln Asp Phe Glu Ser Asp Leu Asp Arg Leu Lys Glu Glu Ile Glu
                645                 650                 655     
Lys Ser Ser Lys Gln Arg Ala Met Leu Ala Gly Ala Thr Ala Val Tyr
            660                 665                 670         
Ser Gln Phe Ile Thr Gln Leu Thr Asp Glu Asn Gln Ser Cys Cys Pro
        675                 680                 685             
Val Cys Gln Arg Val Phe Gln Thr Glu Ala Glu Leu Gln Glu Ala Ile
    690                 695                 700                 
Ser Asp Leu Gln Ser Lys Leu Arg Leu Ala Pro Asp Lys Leu Lys Ser
705                 710                 715                 720 
Thr Glu Ser Glu Leu Lys Lys Lys Glu Lys Arg Arg Asp Glu Met Leu
                725                 730                 735     
Gly Leu Ala Pro Met Arg Gln Ser Ile Ile Asp Leu Lys Glu Lys Glu
            740                 745                 750         
Ile Pro Glu Leu Arg Asn Lys Leu Gln Asn Val Asn Arg Asp Ile Gln
        755                 760                 765             
Arg Leu Lys Asn Asp Ile Glu Glu Gln Glu Thr Leu Leu Gly Thr Ile
    770                 775                 780                 
Met Pro Glu Glu Glu Ser Ala Lys Val Cys Leu Thr Asp Val Thr Ile
785                 790                 795                 800 
Met Glu Arg Phe Gln Met Glu Leu Lys Asp Val Glu Arg Lys Ile Ala
                805                 810                 815     
Gln Gln Ala Ala Lys Leu Gln Gly Ile Asp Leu Asp Arg Thr Val Gln
            820                 825                 830         
Gln Val Asn Gln Glu Lys Gln Glu Lys Gln His Lys Leu Asp Thr Val
        835                 840                 845             
Ser Ser Lys Ile Glu Leu Asn Arg Lys Leu Ile Gln Asp Gln Gln Glu
    850                 855                 860                 
Gln Ile Gln His Leu Lys Ser Thr Thr Asn Glu Leu Lys Ser Glu Lys
865                 870                 875                 880 
Leu Gln Ile Ser Thr Asn Leu Gln Arg Arg Gln Gln Leu Glu Glu Gln
                885                 890                 895     
Thr Val Glu Leu Ser Thr Glu Val Gln Ser Leu Tyr Arg Glu Ile Lys
            900                 905                 910         
Asp Ala Lys Glu Gln Val Ser Pro Leu Glu Thr Thr Leu Glu Lys Phe
        915                 920                 925             
Gln Gln Glu Lys Glu Glu Leu Ile Asn Lys Lys Asn Thr Ser Asn Lys
    930                 935                 940                 
Ile Ala Gln Asp Lys Leu Asn Asp Ile Lys Glu Lys Val Lys Asn Ile
945                 950                 955                 960 
His Gly Tyr Met Lys Asp Ile Glu Asn His Ile Gln Asp Gly Lys Asp
                965                 970                 975     
Asp Tyr Met Lys Gln Lys Glu Thr Glu Leu Asn Lys Val Ile Ala Gln
            980                 985                 990         
Leu Ser Glu Cys Glu Lys His Lys Glu Lys Ile Asn Glu Asp Met Arg
        995                 1000                1005            
Leu Met Arg Gln Asp Ile Asp Thr Gln Lys Ile Gln Glu Arg Trp Leu
    1010                1015                1020                
Gln Asp Asn Leu Thr Leu Arg Lys Arg Asn Glu Glu Leu Lys Glu Val
1025                1030                1035                1040
Glu Glu Glu Gly Lys Gln His Leu Lys Glu Met Gly Gln Met Gln Val
                1045                1050                1055    
Leu Gln Met Lys Ser Glu His Gln Lys Leu Glu Glu Asn Ile Asp Asn
            1060                1065                1070        
Ile Lys Arg Asn His Asn Leu Ala Leu Gly Arg Gln Lys Gly Tyr Glu
        1075                1080                1085            
Glu Glu Ile Ile His Phe Lys Lys Glu Leu Arg Glu Pro Gln Phe Arg
    1090                1095                1100                
Asp Ala Glu Glu Lys Tyr Arg Glu Met Met Ile Val Met Arg Thr Thr
1105                1110                1115                1120
Glu Leu Val Asn Lys Asp Leu Asp Ile Tyr Tyr Lys Thr Leu Asp Gln
                1125                1130                1135    
Ala Ile Met Lys Phe His Ser Met Lys Met Glu Glu Ile Asn Lys Ile
            1140                1145                1150        
Ile Arg Asp Leu Trp Arg Ser Thr Tyr Arg Gly Gln Asp Ile Glu Tyr
        1155                1160                1165            
Ile Glu Ile Arg Ser Asp Ala Asp Glu Asn Val Ser Ala Ser Asp Lys
    1170                1175                1180                
Arg Arg Asn Tyr Asn Tyr Arg Val Val Met Leu Lys Gly Asp Thr Ala
1185                1190                1195                1200
Leu Asp Met Arg Gly Arg Cys Ser Ala Gly Gln Lys Val Leu Ala Ser
                1205                1210                1215    
Leu Ile Ile Arg Leu Ala Leu Ala Glu Thr Phe Cys Leu Asn Cys Gly
            1220                1225                1230        
Ile Ile Ala Leu Asp Glu Pro Thr Thr Asn Leu Asp Arg Glu Asn Ile
        1235                1240                1245            
Glu Ser Leu Ala His Ala Leu Val Glu Ile Ile Lys Ser Arg Ser Gln
    1250                1255                1260                
Gln Arg Asn Phe Gln Leu Leu Val Ile Thr His Asp Glu Asp Phe Val
1265                1270                1275                1280
Glu Leu Leu Gly Arg Ser Glu Tyr Val Glu Lys Phe Tyr Arg Ile Lys
                1285                1290                1295    
Lys Asn Ile Asp Gln Cys Ser Glu Ile Val Lys Cys Ser Val Ser Ser
            1300                1305                1310        
Leu Gly Phe Asn Val His
        1315            


<210> 667
<211> 151
<212> PRT
<213> Homo sapiens

<400> 667
Met Ala Pro Arg Lys Gly Lys Glu Lys Lys Glu Glu Gln Val Ile Ser
 1               5                  10                  15      
Leu Gly Pro Gln Val Ala Glu Gly Glu Asn Val Phe Gly Val Cys His
            20                  25                  30          
Ile Phe Ala Ser Phe Asn Asp Thr Phe Val His Val Thr Asp Leu Ser
        35                  40                  45              
Gly Lys Glu Thr Ile Cys Arg Val Thr Gly Gly Met Lys Val Lys Ala
    50                  55                  60                  
Asp Arg Asp Glu Ser Ser Pro Tyr Ala Ala Met Leu Ala Ala Gln Asp
65                  70                  75                  80  
Val Ala Gln Arg Cys Lys Glu Leu Gly Ile Thr Ala Leu His Ile Lys
                85                  90                  95      
Leu Arg Ala Thr Gly Gly Asn Arg Thr Lys Thr Pro Gly Pro Gly Ala
            100                 105                 110         
Gln Ser Ala Leu Arg Ala Leu Ala Arg Ser Gly Met Lys Ile Gly Arg
        115                 120                 125             
Ile Glu Asp Val Thr Pro Ile Pro Ser Asp Ser Thr Arg Arg Lys Gly
    130                 135                 140                 
Gly Arg Arg Gly Arg Arg Leu
145                 150     


<210> 668
<211> 643
<212> PRT
<213> Homo sapiens

<400> 668
Met Gly Leu Leu Pro Lys Leu Gly Val Ser Gln Gly Ser Asp Thr Ser
 1               5                  10                  15      
Thr Ser Arg Ala Gly Arg Cys Ala Arg Ser Val Phe Gly Asn Ile Lys
            20                  25                  30          
Val Phe Val Leu Cys Gln Gly Leu Leu Gln Leu Cys Gln Leu Leu Tyr
        35                  40                  45              
Ser Ala Tyr Phe Lys Ser Ser Leu Thr Thr Ile Glu Lys Arg Phe Gly
    50                  55                  60                  
Leu Ser Ser Ser Ser Ser Gly Leu Ile Ser Ser Leu Asn Glu Ile Ser
65                  70                  75                  80  
Asn Ala Ile Leu Ile Ile Phe Val Ser Tyr Phe Gly Ser Arg Val His
                85                  90                  95      
Arg Pro Arg Leu Ile Gly Ile Gly Gly Leu Phe Leu Ala Ala Gly Ala
            100                 105                 110         
Phe Ile Leu Thr Leu Pro His Phe Leu Ser Glu Pro Tyr Gln Tyr Thr
        115                 120                 125             
Leu Ala Ser Thr Gly Asn Asn Ser Arg Leu Gln Ala Glu Leu Cys Gln
    130                 135                 140                 
Lys His Trp Gln Asp Leu Pro Pro Ser Lys Cys His Ser Thr Thr Gln
145                 150                 155                 160 
Asn Pro Gln Lys Glu Thr Ser Ser Met Trp Gly Leu Met Val Val Ala
                165                 170                 175     
Gln Leu Leu Ala Gly Ile Gly Thr Val Pro Ile Gln Pro Phe Gly Ile
            180                 185                 190         
Ser Tyr Val Asp Asp Phe Ser Glu Pro Ser Asn Ser Pro Leu Tyr Ile
        195                 200                 205             
Ser Ile Leu Phe Ala Ile Ser Val Phe Gly Pro Ala Phe Gly Tyr Leu
    210                 215                 220                 
Leu Gly Ser Ile Met Leu Gln Ile Phe Val Asp Tyr Gly Arg Val Asn
225                 230                 235                 240 
Thr Ala Ala Val Asn Leu Val Pro Gly Asp Pro Arg Trp Ile Gly Ala
                245                 250                 255     
Trp Trp Leu Gly Leu Leu Ile Ser Ser Ala Leu Leu Val Leu Thr Ser
            260                 265                 270         
Phe Pro Phe Phe Phe Phe Pro Arg Ala Met Pro Ile Gly Ala Lys Arg
        275                 280                 285             
Ala Pro Ala Thr Ala Asp Glu Ala Arg Lys Leu Glu Glu Ala Lys Ser
    290                 295                 300                 
Arg Gly Ser Leu Val Asp Phe Ile Lys Arg Phe Pro Cys Ile Phe Leu
305                 310                 315                 320 
Arg Leu Leu Met Asn Ser Leu Phe Val Leu Val Val Leu Ala Gln Cys
                325                 330                 335     
Thr Phe Ser Ser Val Ile Ala Gly Leu Ser Thr Phe Leu Asn Lys Phe
            340                 345                 350         
Leu Glu Lys Gln Tyr Gly Thr Ser Ala Ala Tyr Ala Asn Phe Leu Ile
        355                 360                 365             
Gly Ala Val Asn Leu Pro Ala Ala Ala Leu Gly Met Leu Phe Gly Gly
    370                 375                 380                 
Ile Leu Met Lys Arg Phe Val Phe Ser Leu Gln Thr Ile Pro Arg Ile
385                 390                 395                 400 
Ala Thr Thr Ile Ile Thr Ile Ser Met Ile Leu Cys Val Pro Leu Phe
                405                 410                 415     
Phe Met Gly Cys Ser Thr Pro Thr Val Ala Glu Val Tyr Pro Pro Ser
            420                 425                 430         
Thr Ser Ser Ser Ile His Pro Gln Ser Pro Ala Cys Arg Arg Asp Cys
        435                 440                 445             
Ser Cys Pro Asp Ser Ile Phe His Pro Val Cys Gly Asp Asn Gly Ile
    450                 455                 460                 
Glu Tyr Leu Ser Pro Cys His Ala Gly Cys Ser Asn Ile Asn Met Ser
465                 470                 475                 480 
Ser Ala Thr Ser Lys Gln Leu Ile Tyr Leu Asn Cys Ser Cys Val Thr
                485                 490                 495     
Gly Gly Ser Ala Ser Ala Lys Thr Gly Ser Cys Pro Val Pro Cys Ala
            500                 505                 510         
His Phe Leu Leu Pro Ala Ile Phe Leu Ile Ser Phe Val Ser Leu Ile
        515                 520                 525             
Ala Cys Ile Ser His Asn Pro Leu Tyr Met Met Val Leu Arg Val Val
    530                 535                 540                 
Asn Gln Glu Glu Lys Ser Phe Ala Ile Gly Val Gln Phe Leu Leu Met
545                 550                 555                 560 
Arg Leu Leu Ala Trp Leu Pro Ser Pro Ala Leu Tyr Gly Leu Thr Ile
                565                 570                 575     
Asp His Ser Cys Ile Arg Trp Asn Ser Leu Cys Leu Gly Arg Arg Gly
            580                 585                 590         
Ala Cys Ala Tyr Tyr Asp Asn Asp Ala Leu Arg Asp Arg Tyr Leu Gly
        595                 600                 605             
Leu Gln Met Gly Tyr Lys Ala Leu Gly Met Leu Leu Leu Cys Phe Ile
    610                 615                 620                 
Ser Trp Arg Val Lys Lys Asn Lys Glu Tyr Asn Val Gln Lys Ala Ala
625                 630                 635                 640 
Gly Leu Ile
            


<210> 669
<211> 172
<212> PRT
<213> Homo sapiens

<400> 669
Met Glu Glu Tyr Ala Arg Glu Pro Cys Pro Trp Arg Ile Val Asp Asp
 1               5                  10                  15      
Cys Gly Gly Ala Phe Thr Met Gly Val Ile Gly Gly Gly Val Phe Gln
            20                  25                  30          
Ala Ile Lys Gly Phe Arg Asn Ala Pro Val Gly Ile Arg His Arg Leu
        35                  40                  45              
Arg Gly Ser Ala Asn Ala Val Arg Ile Arg Ala Pro Gln Ile Gly Gly
    50                  55                  60                  
Ser Phe Ala Val Trp Gly Gly Leu Phe Ser Thr Ile Asp Cys Gly Leu
65                  70                  75                  80  
Val Arg Leu Arg Gly Lys Glu Asp Pro Trp Asn Ser Ile Thr Ser Gly
                85                  90                  95      
Ala Leu Thr Gly Ala Val Leu Ala Ala Arg Ser Gly Pro Leu Ala Met
            100                 105                 110         
Val Gly Ser Ala Met Met Gly Gly Ile Leu Leu Ala Leu Ile Glu Gly
        115                 120                 125             
Val Gly Ile Leu Leu Thr Arg Tyr Thr Ala Gln Gln Phe Arg Asn Ala
    130                 135                 140                 
Pro Pro Phe Leu Glu Asp Pro Ser Gln Leu Pro Pro Lys Asp Gly Thr
145                 150                 155                 160 
Pro Ala Pro Gly Tyr Pro Ser Tyr Gln Gln Tyr His
                165                 170         


<210> 670
<211> 137
<212> PRT
<213> Homo sapiens

<400> 670
Met Ser Ser Leu Ile Arg Arg Val Ile Ser Thr Ala Lys Ala Pro Gly
 1               5                  10                  15      
Ala Ile Gly Pro Tyr Ser Gln Ala Val Leu Val Asp Arg Thr Ile Tyr
            20                  25                  30          
Ile Ser Gly Gln Ile Gly Met Asp Pro Ser Ser Gly Gln Leu Val Ser
        35                  40                  45              
Gly Gly Val Ala Glu Glu Ala Lys Gln Ala Leu Lys Asn Met Gly Glu
    50                  55                  60                  
Ile Leu Lys Ala Ala Gly Cys Asp Phe Thr Asn Val Val Lys Thr Thr
65                  70                  75                  80  
Val Leu Leu Ala Asp Ile Asn Asp Phe Asn Thr Val Asn Glu Ile Tyr
                85                  90                  95      
Lys Gln Tyr Phe Lys Ser Asn Phe Pro Ala Arg Ala Ala Tyr Gln Val
            100                 105                 110         
Ala Ala Leu Pro Lys Gly Ser Arg Ile Glu Ile Glu Ala Val Ala Ile
        115                 120                 125             
Gln Gly Pro Leu Thr Thr Ala Ser Leu
    130                 135         


<210> 671
<211> 1417
<212> PRT
<213> Homo sapiens

<400> 671
Met Leu Gly Thr Gly Pro Ala Ala Ala Thr Thr Ala Ala Thr Thr Ser
 1               5                  10                  15      
Ser Asn Val Ser Val Leu Gln Gln Phe Ala Ser Gly Leu Lys Ser Arg
            20                  25                  30          
Asn Glu Glu Thr Arg Ala Lys Ala Ala Lys Glu Leu Gln His Tyr Val
        35                  40                  45              
Thr Met Glu Leu Arg Glu Met Ser Gln Glu Glu Ser Thr Arg Phe Tyr
    50                  55                  60                  
Asp Gln Leu Asn His His Ile Phe Glu Leu Val Ser Ser Ser Asp Ala
65                  70                  75                  80  
Asn Glu Arg Lys Gly Gly Ile Leu Ala Ile Ala Ser Leu Ile Gly Val
                85                  90                  95      
Glu Gly Gly Asn Ala Thr Arg Ile Gly Arg Phe Ala Asn Tyr Leu Arg
            100                 105                 110         
Asn Leu Leu Pro Ser Asn Asp Pro Val Val Met Glu Met Ala Ser Lys
        115                 120                 125             
Ala Ile Gly Arg Leu Ala Met Ala Gly Asp Thr Phe Thr Ala Glu Tyr
    130                 135                 140                 
Val Glu Phe Glu Val Lys Arg Ala Leu Glu Trp Leu Gly Ala Asp Arg
145                 150                 155                 160 
Asn Glu Gly Arg Arg His Ala Ala Val Leu Val Leu Arg Glu Leu Ala
                165                 170                 175     
Ile Ser Val Pro Thr Phe Phe Phe Gln Gln Val Gln Pro Phe Phe Asp
            180                 185                 190         
Asn Ile Phe Val Ala Val Trp Asp Pro Lys Gln Ala Ile Arg Glu Gly
        195                 200                 205             
Ala Val Ala Ala Leu Arg Ala Cys Leu Ile Leu Thr Thr Gln Arg Glu
    210                 215                 220                 
Pro Lys Glu Met Gln Lys Pro Gln Trp Tyr Arg His Thr Phe Glu Glu
225                 230                 235                 240 
Ala Glu Lys Gly Phe Asp Glu Thr Leu Ala Lys Glu Lys Gly Met Asn
                245                 250                 255     
Arg Asp Asp Arg Ile His Gly Ala Leu Leu Ile Leu Asn Glu Leu Val
            260                 265                 270         
Arg Ile Ser Ser Met Glu Gly Glu Arg Leu Arg Glu Glu Met Glu Glu
        275                 280                 285             
Ile Thr Gln Gln Gln Leu Val His Asp Lys Tyr Cys Lys Asp Leu Met
    290                 295                 300                 
Gly Phe Gly Thr Lys Pro Arg His Ile Thr Pro Phe Thr Ser Phe Gln
305                 310                 315                 320 
Ala Val Gln Pro Gln Gln Ser Asn Ala Leu Val Gly Leu Leu Gly Tyr
                325                 330                 335     
Ser Ser His Gln Gly Leu Met Gly Phe Gly Thr Ser Pro Ser Pro Ala
            340                 345                 350         
Lys Ser Thr Leu Val Glu Ser Arg Cys Cys Arg Asp Leu Met Glu Glu
        355                 360                 365             
Lys Phe Asp Gln Val Cys Gln Trp Val Leu Lys Cys Arg Asn Ser Lys
    370                 375                 380                 
Asn Ser Leu Ile Gln Met Thr Ile Leu Asn Leu Leu Pro Arg Leu Ala
385                 390                 395                 400 
Ala Phe Arg Pro Ser Ala Phe Thr Asp Thr Gln Tyr Leu Gln Asp Thr
                405                 410                 415     
Met Asn His Val Leu Ser Cys Val Lys Lys Glu Lys Glu Arg Thr Ala
            420                 425                 430         
Ala Phe Gln Ala Leu Gly Leu Leu Ser Val Ala Val Arg Ser Glu Phe
        435                 440                 445             
Lys Val Tyr Leu Pro Arg Val Leu Asp Ile Ile Arg Ala Ala Leu Pro
    450                 455                 460                 
Pro Lys Asp Phe Ala His Lys Arg Gln Lys Ala Met Gln Val Asp Ala
465                 470                 475                 480 
Thr Val Phe Thr Cys Ile Ser Met Leu Ala Arg Ala Met Gly Pro Gly
                485                 490                 495     
Ile Gln Gln Asp Ile Lys Glu Leu Leu Glu Pro Met Leu Ala Val Gly
            500                 505                 510         
Leu Ser Pro Ala Leu Thr Ala Val Leu Tyr Asp Leu Ser Arg Gln Ile
        515                 520                 525             
Pro Gln Leu Lys Lys Asp Ile Gln Asp Gly Leu Leu Lys Met Leu Ser
    530                 535                 540                 
Leu Val Leu Met His Lys Pro Leu Arg His Pro Gly Met Pro Lys Gly
545                 550                 555                 560 
Leu Ala His Gln Leu Ala Ser Pro Gly Leu Thr Thr Leu Pro Glu Ala
                565                 570                 575     
Ser Asp Val Gly Ser Ile Thr Leu Ala Leu Arg Thr Leu Gly Ser Phe
            580                 585                 590         
Glu Phe Glu Gly His Ser Leu Thr Gln Phe Val Arg His Cys Ala Asp
        595                 600                 605             
His Phe Leu Asn Ser Glu His Lys Glu Ile Arg Met Glu Ala Ala Arg
    610                 615                 620                 
Thr Cys Ser Arg Leu Leu Thr Pro Ser Ile His Leu Ile Ser Gly His
625                 630                 635                 640 
Ala His Val Val Ser Gln Thr Ala Val Gln Val Val Ala Asp Val Leu
                645                 650                 655     
Ser Lys Leu Leu Val Val Gly Ile Thr Asp Pro Asp Pro Asp Ile Arg
            660                 665                 670         
Tyr Cys Val Leu Ala Ser Leu Asp Glu Arg Phe Asp Ala His Leu Ala
        675                 680                 685             
Gln Ala Glu Asn Leu Gln Ala Leu Phe Val Ala Leu Asn Asp Gln Val
    690                 695                 700                 
Phe Glu Ile Arg Glu Leu Ala Ile Cys Thr Val Gly Arg Leu Ser Ser
705                 710                 715                 720 
Met Asn Pro Ala Phe Val Met Pro Phe Leu Arg Lys Met Leu Ile Gln
                725                 730                 735     
Ile Leu Thr Glu Leu Glu His Ser Gly Ile Gly Arg Ile Lys Glu Gln
            740                 745                 750         
Ser Ala Arg Met Leu Gly His Leu Val Ser Asn Ala Pro Arg Leu Ile
        755                 760                 765             
Arg Pro Tyr Met Glu Pro Ile Leu Lys Ala Leu Ile Leu Lys Leu Lys
    770                 775                 780                 
Asp Pro Asp Pro Asp Pro Asn Pro Gly Val Ile Asn Asn Val Leu Ala
785                 790                 795                 800 
Thr Ile Gly Glu Leu Ala Gln Val Ser Gly Leu Glu Met Arg Lys Trp
                805                 810                 815     
Val Asp Glu Leu Phe Ile Ile Ile Met Asp Met Leu Gln Asp Ser Ser
            820                 825                 830         
Leu Leu Ala Lys Arg Gln Val Ala Leu Trp Thr Leu Gly Gln Leu Val
        835                 840                 845             
Ala Ser Thr Gly Tyr Val Val Glu Pro Tyr Arg Lys Tyr Pro Thr Leu
    850                 855                 860                 
Leu Glu Val Leu Leu Asn Phe Leu Lys Thr Glu Gln Asn Gln Gly Thr
865                 870                 875                 880 
Arg Arg Glu Ala Ile Arg Val Leu Gly Leu Leu Gly Ala Leu Asp Pro
                885                 890                 895     
Tyr Lys His Lys Val Asn Ile Gly Met Ile Asp Gln Ser Arg Asp Ala
            900                 905                 910         
Ser Ala Val Ser Leu Ser Glu Ser Lys Ser Ser Gln Asp Ser Ser Asp
        915                 920                 925             
Tyr Ser Thr Ser Glu Met Leu Val Asn Met Gly Asn Leu Pro Leu Asp
    930                 935                 940                 
Glu Phe Tyr Pro Ala Val Ser Met Val Ala Leu Met Arg Ile Phe Arg
945                 950                 955                 960 
Asp Gln Ser Leu Ser His His His Thr Met Val Val Gln Ala Ile Thr
                965                 970                 975     
Phe Ile Phe Lys Ser Leu Gly Leu Lys Cys Val Gln Phe Leu Pro Gln
            980                 985                 990         
Val Met Pro Thr Phe Leu Asn Val Ile Arg Val Cys Asp Gly Ala Ile
        995                 1000                1005            
Arg Glu Phe Leu Phe Gln Gln Leu Gly Met Leu Val Ser Phe Val Lys
    1010                1015                1020                
Ser His Ile Arg Pro Tyr Met Asp Glu Ile Val Thr Leu Met Arg Glu
1025                1030                1035                1040
Phe Trp Val Met Asn Thr Ser Ile Gln Ser Thr Ile Ile Leu Leu Ile
                1045                1050                1055    
Glu Gln Ile Val Val Ala Leu Gly Gly Glu Phe Lys Leu Tyr Leu Pro
            1060                1065                1070        
Gln Leu Ile Pro His Met Leu Arg Val Phe Met His Asp Asn Ser Pro
        1075                1080                1085            
Gly Arg Ile Val Ser Ile Lys Leu Leu Ala Ala Ile Gln Leu Phe Gly
    1090                1095                1100                
Ala Asn Leu Asp Asp Tyr Leu His Leu Leu Leu Pro Pro Ile Val Lys
1105                1110                1115                1120
Leu Phe Asp Ala Pro Glu Ala Pro Leu Pro Ser Arg Lys Ala Ala Leu
                1125                1130                1135    
Glu Thr Val Asp Arg Leu Thr Glu Ser Leu Asp Phe Thr Asp Tyr Ala
            1140                1145                1150        
Ser Arg Ile Ile His Pro Ile Val Arg Thr Leu Asp Gln Ser Pro Glu
        1155                1160                1165            
Leu Arg Ser Thr Ala Met Asp Thr Leu Ser Ser Leu Val Phe Gln Leu
    1170                1175                1180                
Gly Lys Lys Tyr Gln Ile Phe Ile Pro Met Val Asn Lys Val Leu Val
1185                1190                1195                1200
Arg His Arg Ile Asn His Gln Arg Tyr Asp Val Leu Ile Cys Arg Ile
                1205                1210                1215    
Val Lys Gly Tyr Thr Leu Ala Asp Glu Glu Glu Asp Pro Leu Ile Tyr
            1220                1225                1230        
Gln His Arg Met Leu Arg Ser Gly Gln Gly Asp Ala Leu Ala Ser Gly
        1235                1240                1245            
Pro Val Glu Thr Gly Pro Met Lys Lys Leu His Val Ser Thr Ile Asn
    1250                1255                1260                
Leu Gln Lys Ala Trp Gly Ala Ala Arg Arg Val Ser Lys Asp Asp Trp
1265                1270                1275                1280
Leu Glu Trp Leu Arg Arg Leu Ser Leu Glu Leu Leu Lys Asp Ser Ser
                1285                1290                1295    
Ser Pro Ser Leu Arg Ser Cys Trp Ala Leu Ala Gln Ala Tyr Asn Pro
            1300                1305                1310        
Met Ala Arg Asp Leu Phe Asn Ala Ala Phe Val Ser Cys Trp Ser Glu
        1315                1320                1325            
Leu Asn Glu Asp Gln Gln Asp Glu Leu Ile Arg Ser Ile Glu Leu Ala
    1330                1335                1340                
Leu Thr Ser Gln Asp Ile Ala Glu Val Thr Gln Thr Leu Leu Asn Leu
1345                1350                1355                1360
Ala Glu Phe Met Glu His Ser Asp Lys Gly Pro Leu Pro Leu Arg Asp
                1365                1370                1375    
Asp Asn Gly Ile Val Leu Leu Gly Glu Arg Ala Ala Lys Cys Arg Ala
            1380                1385                1390        
Tyr Ala Lys Ala Leu His Tyr Lys Glu Leu Glu Phe Gln Lys Gly Pro
        1395                1400                1405            
Thr Pro Ala Ile Leu Glu Ser Leu Ile
    1410                1415        


<210> 672
<211> 182
<212> PRT
<213> Homo sapiens

<400> 672
Met Ala Arg Leu Leu Trp Leu Leu Arg Gly Leu Thr Leu Gly Thr Ala
 1               5                  10                  15      
Pro Arg Arg Ala Val Arg Gly Gln Ala Gly Gly Gly Gly Pro Gly Thr
            20                  25                  30          
Gly Pro Gly Leu Gly Glu Ala Gly Ser Leu Ala Thr Cys Glu Leu Pro
        35                  40                  45              
Leu Ala Lys Ser Glu Trp Gln Lys Lys Leu Thr Pro Glu Gln Phe Tyr
    50                  55                  60                  
Val Thr Arg Glu Lys Gly Thr Glu Pro Pro Phe Ser Gly Ile Tyr Leu
65                  70                  75                  80  
Asn Asn Lys Glu Ala Gly Met Tyr His Cys Val Cys Cys Asp Ser Pro
                85                  90                  95      
Leu Phe Ser Ser Glu Lys Lys Tyr Cys Ser Gly Thr Gly Trp Pro Ser
            100                 105                 110         
Phe Ser Glu Ala His Gly Thr Ser Gly Ser Asp Glu Ser His Thr Gly
        115                 120                 125             
Ile Leu Arg Arg Leu Asp Thr Ser Leu Gly Ser Ala Arg Thr Glu Val
    130                 135                 140                 
Val Cys Lys Gln Cys Glu Ala His Leu Gly His Val Phe Pro Asp Gly
145                 150                 155                 160 
Pro Gly Pro Asn Gly Gln Arg Phe Cys Ile Asn Ser Val Ala Leu Lys
                165                 170                 175     
Phe Lys Pro Arg Lys His
            180         


<210> 673
<211> 294
<212> PRT
<213> Homo sapiens

<400> 673
Met Ala Thr His Gly Gln Thr Cys Ala Arg Pro Met Cys Ile Pro Pro
 1               5                  10                  15      
Ser Tyr Ala Asp Leu Gly Lys Ala Ala Arg Asp Ile Phe Asn Lys Gly
            20                  25                  30          
Phe Gly Phe Gly Leu Val Lys Leu Asp Val Lys Thr Lys Ser Cys Ser
        35                  40                  45              
Gly Val Glu Phe Ser Thr Ser Gly Ser Ser Asn Thr Asp Thr Gly Lys
    50                  55                  60                  
Val Thr Gly Thr Leu Glu Thr Lys Tyr Lys Trp Cys Glu Tyr Gly Leu
65                  70                  75                  80  
Thr Phe Thr Glu Lys Trp Asn Thr Asp Asn Thr Leu Gly Thr Glu Ile
                85                  90                  95      
Ala Ile Glu Asp Gln Ile Cys Gln Gly Leu Lys Leu Thr Phe Asp Thr
            100                 105                 110         
Thr Phe Ser Pro Asn Thr Gly Lys Lys Ser Gly Lys Ile Lys Ser Ser
        115                 120                 125             
Tyr Lys Arg Glu Cys Ile Asn Leu Gly Cys Asp Val Asp Phe Asp Phe
    130                 135                 140                 
Ala Gly Pro Ala Ile His Gly Ser Ala Val Phe Gly Tyr Glu Gly Trp
145                 150                 155                 160 
Leu Ala Gly Tyr Gln Met Thr Phe Asp Ser Ala Lys Ser Lys Leu Thr
                165                 170                 175     
Arg Asn Asn Phe Ala Val Gly Tyr Arg Thr Gly Asp Phe Gln Leu His
            180                 185                 190         
Thr Asn Val Asn Asp Gly Thr Glu Phe Gly Gly Ser Ile Tyr Gln Lys
        195                 200                 205             
Val Cys Glu Asp Leu Asp Thr Ser Val Asn Leu Ala Trp Thr Ser Gly
    210                 215                 220                 
Thr Asn Cys Thr Arg Phe Gly Ile Ala Ala Lys Tyr Gln Leu Asp Pro
225                 230                 235                 240 
Thr Ala Ser Ile Ser Ala Lys Val Asn Asn Ser Ser Leu Ile Gly Val
                245                 250                 255     
Gly Tyr Thr Gln Thr Leu Arg Pro Gly Val Lys Leu Thr Leu Ser Ala
            260                 265                 270         
Leu Val Asp Gly Lys Ser Ile Asn Ala Gly Gly His Lys Val Gly Leu
        275                 280                 285             
Ala Leu Glu Leu Glu Ala
    290                 


<210> 674
<211> 263
<212> PRT
<213> Homo sapiens

<400> 674
Met Ala Ala Gly Arg Tyr Arg Leu Trp Trp Arg Gly Ile Leu Gly Ala
 1               5                  10                  15      
Ser Ala Leu Thr Arg Gly Thr Gly Arg Pro Ser Val Leu Leu Leu Pro
            20                  25                  30          
Val Arg Arg Glu Ser Ala Gly Ala Asp Thr Arg Pro Thr Val Arg Pro
        35                  40                  45              
Arg Asn Asp Val Ala His Lys Gln Leu Ser Ala Phe Gly Glu Tyr Val
    50                  55                  60                  
Ala Glu Ile Leu Pro Lys Tyr Val Gln Gln Val Gln Val Ser Cys Phe
65                  70                  75                  80  
Asn Glu Leu Glu Val Cys Ile His Pro Asp Gly Val Ile Pro Val Leu
                85                  90                  95      
Thr Phe Leu Arg Asp His Thr Asn Ala Gln Phe Lys Ser Leu Val Asp
            100                 105                 110         
Leu Thr Ala Val Asp Val Pro Thr Arg Gln Asn Arg Phe Glu Ile Val
        115                 120                 125             
Tyr Asn Leu Leu Ser Leu Arg Phe Asn Ser Arg Ile Arg Val Lys Thr
    130                 135                 140                 
Tyr Thr Asp Glu Leu Thr Pro Ile Glu Ser Ala Val Ser Val Phe Lys
145                 150                 155                 160 
Ala Ala Asn Trp Tyr Glu Arg Glu Ile Trp Asp Met Phe Gly Val Phe
                165                 170                 175     
Phe Ala Asn His Pro Asp Leu Arg Arg Ile Leu Thr Asp Tyr Gly Phe
            180                 185                 190         
Glu Gly His Pro Phe Arg Lys Asp Phe Pro Leu Ser Gly Tyr Val Glu
        195                 200                 205             
Leu Arg Tyr Asp Asp Glu Val Lys Arg Val Val Ala Glu Pro Val Glu
    210                 215                 220                 
Leu Ala Gln Glu Phe Arg Lys Phe Asp Leu Asn Ser Pro Trp Glu Ala
225                 230                 235                 240 
Phe Pro Val Tyr Arg Gln Pro Pro Glu Ser Leu Lys Leu Glu Ala Gly
                245                 250                 255     
Asp Lys Lys Pro Asp Ala Lys
            260             


<210> 675
<211> 334
<212> PRT
<213> Homo sapiens

<400> 675
Met Ser Glu Pro Ile Arg Val Leu Val Thr Gly Ala Ala Gly Gln Ile
 1               5                  10                  15      
Ala Tyr Ser Leu Leu Tyr Ser Ile Gly Asn Gly Ser Val Phe Gly Lys
            20                  25                  30          
Asp Gln Pro Ile Ile Leu Val Leu Leu Asp Ile Thr Pro Met Met Gly
        35                  40                  45              
Val Leu Asp Gly Val Leu Met Glu Leu Gln Asp Cys Ala Leu Pro Leu
    50                  55                  60                  
Leu Lys Asp Val Ile Ala Thr Asp Lys Glu Asp Val Ala Phe Lys Asp
65                  70                  75                  80  
Leu Asp Val Ala Ile Leu Val Gly Ser Met Pro Arg Arg Glu Gly Met
                85                  90                  95      
Glu Arg Lys Asp Leu Leu Lys Ala Asn Val Lys Ile Phe Lys Ser Gln
            100                 105                 110         
Gly Ala Ala Leu Asp Lys Tyr Ala Lys Lys Ser Val Lys Val Ile Val
        115                 120                 125             
Val Gly Asn Pro Ala Asn Thr Asn Cys Leu Thr Ala Ser Lys Ser Ala
    130                 135                 140                 
Pro Ser Ile Pro Lys Glu Asn Phe Ser Cys Leu Thr Arg Leu Asp His
145                 150                 155                 160 
Asn Arg Ala Lys Ala Gln Ile Ala Leu Lys Leu Gly Val Thr Ala Asn
                165                 170                 175     
Asp Val Lys Asn Val Ile Ile Trp Gly Asn His Ser Ser Thr Gln Tyr
            180                 185                 190         
Pro Asp Val Asn His Ala Lys Val Lys Leu Gln Gly Lys Glu Val Gly
        195                 200                 205             
Val Tyr Glu Ala Leu Lys Asp Asp Ser Trp Leu Lys Gly Glu Phe Val
    210                 215                 220                 
Thr Thr Val Gln Gln Arg Gly Ala Ala Val Ile Lys Ala Arg Lys Leu
225                 230                 235                 240 
Ser Ser Ala Met Ser Ala Ala Lys Ala Ile Cys Asp His Val Arg Asp
                245                 250                 255     
Ile Trp Phe Gly Thr Pro Glu Gly Glu Phe Val Ser Met Gly Val Ile
            260                 265                 270         
Ser Asp Gly Asn Ser Tyr Gly Val Pro Asp Asp Leu Leu Tyr Ser Phe
        275                 280                 285             
Pro Val Val Ile Lys Asn Lys Thr Trp Lys Phe Val Glu Gly Leu Pro
    290                 295                 300                 
Ile Asn Asp Phe Ser Arg Glu Lys Met Asp Leu Thr Ala Lys Glu Leu
305                 310                 315                 320 
Thr Glu Glu Lys Glu Ser Ala Phe Glu Phe Leu Ser Ser Ala
                325                 330                 


<210> 676
<211> 334
<212> PRT
<213> Homo sapiens

<400> 676
Met Ser Glu Pro Ile Arg Val Leu Val Thr Gly Ala Ala Gly Gln Ile
 1               5                  10                  15      
Ala Tyr Ser Leu Leu Tyr Ser Ile Gly Asn Gly Ser Val Phe Gly Lys
            20                  25                  30          
Asp Gln Pro Ile Ile Leu Val Leu Leu Asp Ile Thr Pro Met Met Gly
        35                  40                  45              
Val Leu Asp Gly Val Leu Met Glu Leu Gln Asp Cys Ala Leu Pro Leu
    50                  55                  60                  
Leu Lys Asp Val Ile Ala Thr Asp Lys Glu Asp Val Ala Phe Lys Asp
65                  70                  75                  80  
Leu Asp Val Ala Ile Leu Val Gly Ser Met Pro Arg Arg Glu Gly Met
                85                  90                  95      
Glu Arg Lys Asp Leu Leu Lys Ala Asn Val Lys Ile Phe Lys Ser Gln
            100                 105                 110         
Gly Ala Ala Leu Asp Lys Tyr Ala Lys Lys Ser Val Lys Val Ile Val
        115                 120                 125             
Val Gly Asn Pro Ala Asn Thr Asn Cys Leu Thr Ala Ser Lys Ser Ala
    130                 135                 140                 
Pro Ser Ile Pro Lys Glu Asn Phe Ser Cys Leu Thr Arg Leu Asp His
145                 150                 155                 160 
Asn Arg Ala Lys Ala Gln Ile Ala Leu Lys Leu Gly Val Thr Ala Asn
                165                 170                 175     
Asp Val Lys Asn Val Ile Ile Trp Gly Asn His Ser Ser Thr Gln Tyr
            180                 185                 190         
Pro Asp Val Asn His Ala Lys Val Lys Leu Gln Gly Lys Glu Val Gly
        195                 200                 205             
Val Tyr Glu Ala Leu Lys Asp Asp Ser Trp Leu Lys Gly Glu Phe Val
    210                 215                 220                 
Thr Thr Val Gln Gln Arg Gly Ala Ala Val Ile Lys Ala Arg Lys Leu
225                 230                 235                 240 
Ser Ser Ala Met Ser Ala Ala Lys Ala Ile Cys Asp His Val Arg Asp
                245                 250                 255     
Ile Trp Phe Gly Thr Pro Glu Gly Glu Phe Val Ser Met Gly Val Ile
            260                 265                 270         
Ser Asp Gly Asn Ser Tyr Gly Val Pro Asp Asp Leu Leu Tyr Ser Phe
        275                 280                 285             
Pro Val Val Ile Lys Asn Lys Thr Trp Lys Phe Val Glu Gly Leu Pro
    290                 295                 300                 
Ile Asn Asp Phe Ser Arg Glu Lys Met Asp Leu Thr Ala Lys Glu Leu
305                 310                 315                 320 
Thr Glu Glu Lys Glu Ser Ala Phe Glu Phe Leu Ser Ser Ala
                325                 330                 


<210> 677
<211> 338
<212> PRT
<213> Homo sapiens

<400> 677
Met Leu Ser Ala Leu Ala Arg Pro Val Ser Ala Ala Leu Arg Arg Ser
 1               5                  10                  15      
Phe Ser Thr Ser Ala Gln Asn Asn Ala Lys Val Ala Val Leu Gly Ala
            20                  25                  30          
Ser Gly Gly Ile Gly Gln Pro Leu Ser Leu Leu Leu Lys Asn Ser Pro
        35                  40                  45              
Leu Val Ser Arg Leu Thr Leu Tyr Asp Ile Ala His Thr Pro Gly Val
    50                  55                  60                  
Ala Ala Asp Leu Ser His Ile Glu Thr Lys Ala Ala Val Lys Gly Tyr
65                  70                  75                  80  
Leu Gly Pro Glu Gln Leu Pro Asp Cys Leu Lys Gly Cys Asp Val Val
                85                  90                  95      
Val Ile Pro Ala Gly Val Pro Arg Lys Pro Gly Met Thr Arg Asp Asp
            100                 105                 110         
Leu Phe Asn Thr Asn Ala Thr Ile Val Ala Thr Leu Thr Ala Ala Cys
        115                 120                 125             
Ala Gln His Cys Pro Glu Ala Met Ile Cys Val Ile Ala Asn Pro Val
    130                 135                 140                 
Asn Ser Thr Ile Pro Ile Thr Ala Glu Val Phe Lys Lys His Gly Val
145                 150                 155                 160 
Tyr Asn Pro Asn Lys Ile Phe Gly Val Thr Thr Leu Asp Ile Val Arg
                165                 170                 175     
Ala Asn Thr Phe Val Ala Glu Leu Lys Gly Leu Asp Pro Ala Arg Val
            180                 185                 190         
Asn Val Pro Val Ile Gly Gly His Ala Gly Lys Thr Ile Ile Pro Leu
        195                 200                 205             
Ile Ser Gln Cys Thr Pro Lys Val Asp Phe Pro Gln Asp Gln Leu Thr
    210                 215                 220                 
Ala Leu Thr Gly Arg Ile Gln Glu Ala Gly Thr Glu Val Val Lys Ala
225                 230                 235                 240 
Lys Ala Gly Ala Gly Ser Ala Thr Leu Ser Met Ala Tyr Ala Gly Ala
                245                 250                 255     
Arg Phe Val Phe Ser Leu Val Asp Ala Met Asn Gly Lys Glu Gly Val
            260                 265                 270         
Val Glu Cys Ser Phe Val Lys Ser Gln Glu Thr Glu Cys Thr Tyr Phe
        275                 280                 285             
Ser Thr Pro Leu Leu Leu Gly Lys Lys Gly Ile Glu Lys Asn Leu Gly
    290                 295                 300                 
Ile Gly Lys Val Ser Ser Phe Glu Glu Lys Met Ile Ser Asp Ala Ile
305                 310                 315                 320 
Pro Glu Leu Lys Ala Ser Ile Lys Lys Gly Glu Asp Phe Val Lys Thr
                325                 330                 335     
Leu Lys
        


<210> 678
<211> 398
<212> PRT
<213> Homo sapiens

<400> 678
Met Asp Ile Arg Lys Phe Phe Gly Ala Ile Ser Ser Gly Lys Lys Pro
 1               5                  10                  15      
Val Asn Glu Thr Val Lys Lys Asn Glu Lys Thr Lys Pro Ser Glu Gly
            20                  25                  30          
Thr Val Lys Gly Lys Lys Gly Val Lys Glu Ala Lys Val Asn Asn Pro
        35                  40                  45              
Cys Lys Glu Asp Ala Ser Arg Pro Lys Gln His Asn Lys Lys Lys Arg
    50                  55                  60                  
Ile Ile Tyr Asp Ser Asp Ser Glu Ser Glu Glu Thr Val Gln Val Lys
65                  70                  75                  80  
Asn Ala Lys Lys Lys Ser Glu Lys Leu Pro Val Ser Cys Lys Pro Gly
                85                  90                  95      
Lys Ile Ser Arg Lys Asp Pro Val Thr Tyr Ile Ser Glu Thr Asp Glu
            100                 105                 110         
Asp Asp Asp Phe Leu Cys Lys Lys Ala Ala Ser Lys Ser Lys Glu Asn
        115                 120                 125             
Gly Val Ser Thr Asn Ser Tyr Leu Gly Ala Ser Asn Val Lys Lys Asn
    130                 135                 140                 
Glu Glu Asn Thr Lys Thr Lys Ser Lys Pro Leu Ser Pro Ile Lys Leu
145                 150                 155                 160 
Thr Pro Thr Ser Val Leu Asp Tyr Phe Gly Thr Glu Ser Val Gln Arg
                165                 170                 175     
Ser Gly Lys Lys Met Val Ala Ser Lys Lys Lys Glu Ser Ser Gln Thr
            180                 185                 190         
Pro Asp Asp Ser Arg Leu Asn Asp Glu Ala Ile Ala Lys Gln Leu Gln
        195                 200                 205             
Leu Asp Glu Asp Ala Glu Leu Glu Arg Gln Leu His Glu Asp Glu Glu
    210                 215                 220                 
Phe Ala Arg Thr Leu Ala Leu Leu Asp Glu Glu Pro Lys Thr Lys Lys
225                 230                 235                 240 
Ala Arg Lys Asp Ser Glu Glu Gly Glu Ser Phe Ser Pro Ala Lys Ala
                245                 250                 255     
Glu Leu Ser Lys Ala Ala Lys Gln Lys Ser Pro Ala Asn Glu His Phe
            260                 265                 270         
Ser Ile Gly Arg Lys Thr Tyr Ser Pro Ala Lys Tyr Gly Lys Gly Arg
        275                 280                 285             
Gly Ser Glu Gly Thr Lys Gln Pro Cys Arg Ser Ala His Gln Lys Glu
    290                 295                 300                 
Ala Cys Ser Ser Leu Lys Ala Ser Ser Lys Leu Ala Leu Met Lys Ala
305                 310                 315                 320 
Gln Glu Glu Asn Ser Tyr Lys Glu Thr Glu Leu Leu Ala Ala Lys Arg
                325                 330                 335     
Glu Ser Ala Ile Glu Pro Lys Gly Glu Lys Thr Thr Pro Arg Lys Thr
            340                 345                 350         
Lys Gly Ser Pro Thr Lys Arg Glu Ser Val Ser Pro Glu Asp Ser Glu
        355                 360                 365             
Lys Asn Arg Thr Asn Tyr Gln Ser Leu Ser Lys Leu Leu Lys Ser Arg
    370                 375                 380                 
Arg Ser Gln Ser Pro Gly Leu Gln Arg Asn Thr Gln Gly Ser
385                 390                 395             


<210> 679
<211> 541
<212> PRT
<213> Homo sapiens

<400> 679
Met Lys Phe Leu Ile Phe Ala Phe Phe Gly Gly Val His Leu Leu Ser
 1               5                  10                  15      
Leu Cys Ser Gly Lys Ala Ile Cys Lys Asn Gly Ile Ser Lys Arg Thr
            20                  25                  30          
Phe Glu Glu Ile Lys Glu Glu Ile Ala Ser Cys Gly Asp Val Ala Lys
        35                  40                  45              
Ala Ile Ile Asn Leu Ala Val Tyr Gly Lys Ala Gln Asn Arg Ser Tyr
    50                  55                  60                  
Glu Arg Leu Ala Leu Leu Val Asp Thr Val Gly Pro Arg Leu Ser Gly
65                  70                  75                  80  
Ser Lys Asn Leu Glu Lys Ala Ile Gln Ile Met Tyr Gln Asn Leu Gln
                85                  90                  95      
Gln Asp Gly Leu Glu Lys Val His Leu Glu Pro Val Arg Ile Pro His
            100                 105                 110         
Trp Glu Arg Gly Glu Glu Ser Ala Val Met Leu Glu Pro Arg Ile His
        115                 120                 125             
Lys Ile Ala Ile Leu Gly Leu Gly Ser Ser Ile Gly Thr Pro Pro Glu
    130                 135                 140                 
Gly Ile Thr Ala Glu Val Leu Val Val Thr Ser Phe Asp Glu Leu Gln
145                 150                 155                 160 
Arg Arg Ala Ser Glu Ala Arg Gly Lys Ile Val Val Tyr Asn Gln Pro
                165                 170                 175     
Tyr Ile Asn Tyr Ser Arg Thr Val Gln Tyr Arg Thr Gln Gly Ala Val
            180                 185                 190         
Glu Ala Ala Lys Val Gly Ala Leu Ala Ser Leu Ile Arg Ser Val Ala
        195                 200                 205             
Ser Phe Ser Ile Tyr Ser Pro His Thr Gly Ile Gln Glu Tyr Gln Asp
    210                 215                 220                 
Gly Val Pro Lys Ile Pro Thr Ala Cys Ile Thr Val Glu Asp Ala Glu
225                 230                 235                 240 
Met Met Ser Arg Met Ala Ser His Gly Ile Lys Ile Val Ile Gln Leu
                245                 250                 255     
Lys Met Gly Ala Lys Thr Tyr Pro Asp Thr Asp Ser Phe Asn Thr Val
            260                 265                 270         
Ala Glu Ile Thr Gly Ser Lys Tyr Pro Glu Gln Val Val Leu Val Ser
        275                 280                 285             
Gly His Leu Asp Ser Trp Asp Val Gly Gln Gly Ala Met Asp Asp Gly
    290                 295                 300                 
Gly Gly Ala Phe Ile Ser Trp Glu Ala Leu Ser Leu Ile Lys Asp Leu
305                 310                 315                 320 
Gly Leu Arg Pro Lys Arg Thr Leu Arg Leu Val Leu Trp Thr Ala Glu
                325                 330                 335     
Glu Gln Gly Gly Val Gly Ala Phe Gln Tyr Tyr Gln Leu His Lys Val
            340                 345                 350         
Asn Ile Ser Asn Tyr Ser Leu Val Met Glu Ser Asp Ala Gly Thr Phe
        355                 360                 365             
Leu Pro Thr Gly Leu Gln Phe Thr Gly Ser Glu Lys Ala Arg Ala Ile
    370                 375                 380                 
Met Glu Glu Val Met Ser Leu Leu Gln Pro Leu Asn Ile Thr Gln Val
385                 390                 395                 400 
Leu Ser His Gly Glu Gly Thr Asp Ile Asn Phe Trp Ile Gln Ala Gly
                405                 410                 415     
Val Pro Gly Ala Ser Leu Leu Asp Asp Leu Tyr Lys Tyr Phe Phe Phe
            420                 425                 430         
His His Ser His Gly Asp Thr Met Thr Val Met Asp Pro Ser Arg Trp
        435                 440                 445             
Met Leu Leu Leu Leu Phe Gly Leu Leu Phe Leu Met Leu Leu Gln Thr
    450                 455                 460                 
Trp Lys Lys Cys Cys Leu Gly Pro Arg Asn Ser Lys Lys Glu Thr Phe
465                 470                 475                 480 
Ser Cys Phe Trp Pro Gly Ile Leu Gly Leu Gln Leu Trp Lys Thr Pro
                485                 490                 495     
Leu His Ile Thr Ile Ser Ser Asn Ser Ser Ser Lys His Asn Ser Ile
            500                 505                 510         
Ser Cys Phe Leu Leu Leu Ser Phe Leu Ile Leu Ser Lys Phe Ser Asp
        515                 520                 525             
Ser Arg Lys Arg Asn His Ser Pro Leu Pro Pro Thr Thr
    530                 535                 540     


<210> 680
<211> 444
<212> PRT
<213> Homo sapiens

<400> 680
Met Arg Glu Ile Val His Leu Gln Ala Gly Gln Cys Gly Asn Gln Ile
 1               5                  10                  15      
Gly Ala Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro
            20                  25                  30          
Thr Gly Thr Tyr His Gly Asp Ser Asp Leu Gln Leu Glu Arg Ile Asn
        35                  40                  45              
Val Tyr Tyr Asn Glu Ala Thr Gly Gly Asn Tyr Val Pro Arg Ala Val
    50                  55                  60                  
Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Pro
65                  70                  75                  80  
Phe Gly Gln Ile Phe Arg Pro Asp Asn Phe Val Phe Gly Gln Ser Gly
                85                  90                  95      
Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu
            100                 105                 110         
Val Asp Ala Val Leu Asp Val Val Arg Lys Glu Ala Glu Ser Cys Asp
        115                 120                 125             
Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly
    130                 135                 140                 
Ser Gly Met Gly Thr Leu Leu Ile Ser Lys Met Arg Glu Glu Phe Pro
145                 150                 155                 160 
Asp Arg Ile Met Asn Thr Phe Ser Val Val Pro Ser Pro Lys Val Ser
                165                 170                 175     
Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Val His Gln Leu
            180                 185                 190         
Val Glu Asn Thr Asp Glu Thr Tyr Cys Ile Asp Asn Glu Ala Leu Tyr
        195                 200                 205             
Asp Ile Cys Phe Arg Thr Leu Lys Leu Thr Thr Pro Thr Tyr Gly Asp
    210                 215                 220                 
Leu Asn His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Cys Leu
225                 230                 235                 240 
Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn
                245                 250                 255     
Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Ala Phe Ala Pro
            260                 265                 270         
Leu Thr Ser Arg Gly Ser Gln Gln Tyr Arg Gly Leu Thr Val Pro Glu
        275                 280                 285             
Leu Thr Gln Gln Met Phe Asp Ala Lys Asn Met Met Ala Ala Cys Asp
    290                 295                 300                 
Pro Arg His Gly Arg Tyr Leu Thr Val Ala Ala Val Phe Arg Gly Arg
305                 310                 315                 320 
Met Ser Met Lys Glu Val Asp Glu Gln Met Leu Ser Val Gln Ser Lys
                325                 330                 335     
Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Thr Ala
            340                 345                 350         
Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ala Val Thr Phe Ile
        355                 360                 365             
Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln
    370                 375                 380                 
Phe Thr Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly
385                 390                 395                 400 
Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn
                405                 410                 415     
Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Glu Gln
            420                 425                 430         
Gly Glu Phe Glu Glu Glu Ala Glu Glu Glu Val Ala
        435                 440                 


<210> 681
<211> 274
<212> PRT
<213> Homo sapiens

<400> 681
Met Leu Ser Val Ala Ala Arg Ser Gly Pro Phe Ala Pro Val Leu Ser
 1               5                  10                  15      
Ala Thr Ser Arg Gly Val Ala Gly Ala Leu Arg Pro Leu Val Gln Ala
            20                  25                  30          
Thr Val Pro Ala Thr Pro Glu Gln Pro Val Leu Asp Leu Lys Arg Pro
        35                  40                  45              
Phe Leu Ser Arg Glu Ser Leu Ser Gly Gln Ala Val Arg Arg Pro Leu
    50                  55                  60                  
Val Ala Ser Val Gly Leu Asn Val Pro Ala Ser Val Cys Tyr Ser His
65                  70                  75                  80  
Thr Asp Ile Lys Val Pro Asp Phe Ser Glu Tyr Arg Arg Leu Glu Val
                85                  90                  95      
Leu Asp Ser Thr Lys Ser Ser Arg Glu Ser Ser Glu Ala Arg Lys Gly
            100                 105                 110         
Phe Ser Tyr Leu Val Thr Gly Val Thr Thr Val Gly Val Ala Tyr Ala
        115                 120                 125             
Ala Lys Asn Ala Val Thr Gln Phe Val Ser Ser Met Ser Ala Ser Ala
    130                 135                 140                 
Asp Val Leu Ala Leu Ala Lys Ile Glu Ile Lys Leu Ser Asp Ile Pro
145                 150                 155                 160 
Glu Gly Lys Asn Met Ala Phe Lys Trp Arg Gly Lys Pro Leu Phe Val
                165                 170                 175     
Arg His Arg Thr Gln Lys Glu Ile Glu Gln Glu Ala Ala Val Glu Leu
            180                 185                 190         
Ser Gln Leu Arg Asp Pro Gln His Asp Leu Asp Arg Val Lys Lys Pro
        195                 200                 205             
Glu Trp Val Ile Leu Ile Gly Val Cys Thr His Leu Gly Cys Val Pro
    210                 215                 220                 
Ile Ala Asn Ala Gly Asp Phe Gly Gly Tyr Tyr Cys Pro Cys His Gly
225                 230                 235                 240 
Ser His Tyr Asp Ala Ser Gly Arg Ile Arg Leu Gly Pro Ala Pro Leu
                245                 250                 255     
Asn Leu Glu Val Pro Thr Tyr Glu Phe Thr Ser Asp Asp Met Val Ile
            260                 265                 270         
Val Gly
        


<210> 682
<211> 427
<212> PRT
<213> Homo sapiens

<400> 682
Ala Asn Val Thr Tyr Ser Thr Thr Trp Ser Glu Ala Gln Gln Tyr Leu
 1               5                  10                  15      
Met Asp Asn Pro Thr Phe Ala Glu Asp Glu Glu Leu Gln Asn Met Asp
            20                  25                  30          
Lys Glu Asp Ala Leu Ile Cys Phe Glu Glu His Ile Arg Ala Leu Glu
        35                  40                  45              
Lys Glu Glu Glu Glu Glu Lys Gln Lys Ser Leu Leu Arg Glu Arg Arg
    50                  55                  60                  
Arg Gln Arg Lys Asn Arg Glu Ser Phe Gln Ile Phe Leu Asp Glu Leu
65                  70                  75                  80  
His Glu His Gly Gln Leu His Ser Met Ser Ser Trp Met Glu Leu Tyr
                85                  90                  95      
Pro Thr Ile Ser Ser Asp Ile Arg Phe Thr Asn Met Leu Gly Gln Pro
            100                 105                 110         
Gly Ser Thr Ala Leu Asp Leu Phe Lys Phe Tyr Val Glu Asp Leu Lys
        115                 120                 125             
Ala Arg Tyr His Asp Glu Lys Lys Ile Ile Lys Asp Ile Leu Lys Asp
    130                 135                 140                 
Lys Gly Phe Val Val Glu Val Asn Thr Thr Phe Glu Asp Phe Val Ala
145                 150                 155                 160 
Ile Ile Ser Ser Thr Lys Arg Ser Thr Thr Leu Asp Ala Gly Asn Ile
                165                 170                 175     
Lys Leu Ala Phe Asn Ser Leu Leu Glu Lys Ala Glu Ala Arg Glu Arg
            180                 185                 190         
Glu Arg Glu Lys Glu Glu Ala Arg Lys Met Lys Arg Lys Glu Ser Ala
        195                 200                 205             
Phe Lys Ser Met Leu Lys Gln Ala Ala Pro Pro Ile Glu Leu Asp Ala
    210                 215                 220                 
Val Trp Glu Asp Ile Arg Glu Arg Phe Val Lys Glu Pro Ala Phe Glu
225                 230                 235                 240 
Asp Ile Thr Leu Glu Ser Glu Arg Lys Arg Ile Phe Lys Asp Phe Met
                245                 250                 255     
His Val Leu Glu His Glu Cys Gln His His His Ser Lys Asn Lys Lys
            260                 265                 270         
His Ser Lys Lys Ser Lys Lys His His Arg Lys Arg Ser Arg Ser Arg
        275                 280                 285             
Ser Gly Ser Asp Ser Asp Asp Asp Asp Ser His Ser Lys Lys Lys Arg
    290                 295                 300                 
Gln Arg Ser Glu Ser Arg Ser Ala Ser Glu His Ser Ser Ser Ala Glu
305                 310                 315                 320 
Ser Glu Arg Ser Tyr Lys Lys Ser Lys Lys His Lys Lys Lys Ser Lys
                325                 330                 335     
Lys Arg Arg His Lys Ser Asp Ser Pro Glu Ser Asp Ala Glu Arg Glu
            340                 345                 350         
Lys Asp Lys Lys Glu Lys Asp Arg Glu Ser Glu Lys Asp Arg Thr Arg
        355                 360                 365             
Gln Arg Ser Glu Ser Lys His Lys Ser Pro Lys Lys Lys Thr Gly Lys
    370                 375                 380                 
Asp Ser Gly Asn Trp Asp Thr Ser Gly Ser Glu Leu Ser Glu Gly Glu
385                 390                 395                 400 
Leu Glu Lys Arg Arg Arg Thr Leu Leu Glu His Trp Met Met Ile Asn
                405                 410                 415     
Lys Leu Tyr Gln Ile Tyr Val Tyr Ser Met Ile
            420                 425         


<210> 683
<211> 271
<212> PRT
<213> Homo sapiens

<400> 683
Met Glu Ala Leu Pro Leu Leu Ala Ala Thr Thr Pro Asp His Gly Arg
 1               5                  10                  15      
His Arg Arg Leu Leu Leu Leu Pro Leu Leu Leu Phe Leu Leu Pro Ala
            20                  25                  30          
Gly Ala Val Gln Gly Trp Glu Thr Glu Glu Arg Pro Arg Thr Arg Glu
        35                  40                  45              
Glu Glu Cys His Phe Tyr Ala Gly Gly Gln Val Tyr Pro Gly Glu Ala
    50                  55                  60                  
Ser Arg Val Ser Val Ala Asp His Ser Leu His Leu Ser Lys Ala Lys
65                  70                  75                  80  
Ile Ser Lys Pro Ala Pro Tyr Trp Glu Gly Thr Ala Val Ile Asp Gly
                85                  90                  95      
Glu Phe Lys Glu Leu Lys Leu Thr Asp Tyr Arg Gly Lys Tyr Leu Val
            100                 105                 110         
Phe Phe Phe Tyr Pro Leu Asp Phe Thr Phe Val Cys Pro Thr Glu Ile
        115                 120                 125             
Ile Ala Phe Gly Asp Arg Leu Glu Glu Phe Arg Ser Ile Asn Thr Glu
    130                 135                 140                 
Val Val Ala Cys Ser Val Asp Ser Gln Phe Thr His Leu Ala Trp Ile
145                 150                 155                 160 
Asn Thr Pro Arg Arg Gln Gly Gly Leu Gly Pro Ile Arg Ile Pro Leu
                165                 170                 175     
Leu Ser Asp Leu Thr His Gln Ile Ser Lys Asp Tyr Gly Val Tyr Leu
            180                 185                 190         
Glu Asp Ser Gly His Thr Leu Arg Gly Leu Phe Ile Ile Asp Asp Lys
        195                 200                 205             
Gly Ile Leu Arg Gln Ile Thr Leu Asn Asp Leu Pro Val Gly Arg Ser
    210                 215                 220                 
Val Asp Glu Thr Leu Arg Leu Val Gln Ala Phe Gln Tyr Thr Asp Lys
225                 230                 235                 240 
His Gly Glu Val Cys Pro Ala Gly Trp Lys Pro Gly Ser Glu Thr Ile
                245                 250                 255     
Ile Pro Asp Pro Ala Gly Lys Leu Lys Tyr Phe Asp Lys Leu Asn
            260                 265                 270     


<210> 684
<211> 161
<212> PRT
<213> Homo sapiens

<400> 684
Met Ala Gly Arg Lys Leu Ala Leu Lys Thr Ile Asp Trp Val Ala Phe
 1               5                  10                  15      
Ala Glu Ile Ile Pro Gln Asn Gln Lys Ala Ile Ala Ser Ser Leu Lys
            20                  25                  30          
Ser Trp Asn Glu Thr Leu Thr Ser Arg Leu Ala Ala Leu Pro Glu Asn
        35                  40                  45              
Pro Pro Ala Ile Asp Trp Ala Tyr Tyr Lys Ala Asn Val Ala Lys Ala
    50                  55                  60                  
Gly Leu Val Asp Asp Phe Glu Lys Lys Phe Asn Ala Leu Lys Val Pro
65                  70                  75                  80  
Val Pro Glu Asp Lys Tyr Thr Ala Gln Val Asp Ala Glu Glu Lys Glu
                85                  90                  95      
Asp Val Lys Ser Cys Ala Glu Trp Val Ser Leu Ser Lys Ala Arg Ile
            100                 105                 110         
Val Glu Tyr Glu Lys Glu Met Glu Lys Met Lys Asn Leu Ile Pro Phe
        115                 120                 125             
Asp Gln Met Thr Ile Glu Asp Leu Asn Glu Ala Phe Pro Glu Thr Lys
    130                 135                 140                 
Leu Asp Lys Lys Lys Tyr Pro Tyr Trp Pro His Gln Pro Ile Glu Asn
145                 150                 155                 160 
Leu
    


<210> 685
<211> 839
<212> PRT
<213> Homo sapiens

<400> 685
Met Gly Trp Val Gly Gly Arg Arg Arg Asp Ser Ala Ser Pro Pro Gly
 1               5                  10                  15      
Arg Ser Arg Ser Ala Ala Asp Asp Ile Asn Pro Ala Pro Ala Asn Met
            20                  25                  30          
Glu Gly Gly Gly Gly Ser Val Ala Val Ala Gly Leu Gly Ala Arg Gly
        35                  40                  45              
Ser Gly Ala Ala Ala Ala Thr Val Arg Glu Leu Leu Gln Asp Gly Cys
    50                  55                  60                  
Tyr Ser Asp Phe Leu Asn Glu Asp Phe Asp Val Lys Thr Tyr Thr Ser
65                  70                  75                  80  
Gln Ser Ile His Gln Ala Val Ile Ala Glu Gln Leu Ala Lys Leu Ala
                85                  90                  95      
Gln Gly Ile Ser Gln Leu Asp Arg Glu Leu His Leu Gln Val Val Val
            100                 105                 110         
Arg His Glu Asp Leu Leu Ala Gln Ala Thr Gly Ile Glu Ser Leu Glu
        115                 120                 125             
Gly Val Leu Gln Met Met Gln Thr Arg Ile Gly Ala Leu Gln Gly Ala
    130                 135                 140                 
Val Asp Arg Ile Lys Ala Lys Ile Val Glu Pro Tyr Asn Lys Ile Val
145                 150                 155                 160 
Ala Arg Thr Ala Gln Leu Ala Arg Leu Gln Val Ala Cys Asp Leu Leu
                165                 170                 175     
Arg Arg Ile Ile Arg Ile Leu Asn Leu Ser Lys Arg Leu Gln Gly Gln
            180                 185                 190         
Leu Gln Gly Gly Ser Arg Glu Ile Thr Lys Ala Ala Gln Ser Leu Asn
        195                 200                 205             
Glu Leu Asp Tyr Leu Ser Gln Gly Ile Asp Leu Ser Gly Ile Glu Val
    210                 215                 220                 
Ile Glu Asn Asp Leu Leu Phe Ile Ala Arg Ala Arg Leu Glu Val Glu
225                 230                 235                 240 
Asn Gln Ala Lys Arg Leu Leu Glu Gln Gly Leu Glu Thr Gln Asn Pro
                245                 250                 255     
Thr Gln Val Gly Thr Ala Leu Gln Val Phe Tyr Asn Leu Gly Thr Leu
            260                 265                 270         
Lys Asp Thr Ile Thr Ser Val Val Asp Gly Tyr Cys Ala Thr Leu Glu
        275                 280                 285             
Glu Asn Ile Asn Ser Ala Leu Asp Ile Lys Val Leu Thr Gln Pro Ser
    290                 295                 300                 
Gln Ser Ala Val Arg Gly Gly Pro Gly Arg Ser Thr Met Pro Thr Pro
305                 310                 315                 320 
Gly Asn Thr Ala Ala Leu Arg Ala Ser Leu Trp Thr Asn Met Glu Lys
                325                 330                 335     
Leu Met Asp His Ile Tyr Ala Val Cys Gly Gln Val Gln His Leu Gln
            340                 345                 350         
Lys Val Leu Ala Lys Lys Arg Asp Pro Val Ser His Ile Cys Phe Ile
        355                 360                 365             
Glu Glu Ile Val Lys Asp Gly Gln Pro Glu Ile Phe Tyr Thr Phe Trp
    370                 375                 380                 
Asn Ser Val Thr Gln Ala Leu Ser Ser Gln Phe His Met Ala Thr Asn
385                 390                 395                 400 
Ser Ser Met Phe Leu Lys Gln Ala Phe Glu Gly Glu Tyr Pro Lys Leu
                405                 410                 415     
Leu Arg Leu Tyr Asn Asp Leu Trp Lys Arg Leu Gln Gln Tyr Ser Gln
            420                 425                 430         
His Ile Gln Gly Asn Phe Asn Ala Ser Gly Thr Thr Asp Leu Tyr Val
        435                 440                 445             
Asp Leu Gln His Met Glu Asp Asp Ala Gln Asp Ile Phe Ile Pro Lys
    450                 455                 460                 
Lys Pro Asp Tyr Asp Pro Glu Lys Ala Leu Lys Asp Ser Leu Gln Pro
465                 470                 475                 480 
Tyr Glu Ala Ala Tyr Leu Ser Lys Ser Leu Ser Arg Leu Phe Asp Pro
                485                 490                 495     
Ile Asn Leu Val Phe Pro Pro Gly Gly Arg Asn Pro Pro Ser Ser Asp
            500                 505                 510         
Glu Leu Asp Gly Ile Ile Lys Thr Ile Ala Ser Glu Leu Asn Val Ala
        515                 520                 525             
Ala Val Asp Thr Asn Leu Thr Leu Ala Val Ser Lys Asn Val Ala Lys
    530                 535                 540                 
Thr Ile Gln Leu Tyr Ser Val Lys Ser Glu Gln Leu Leu Pro Thr Gln
545                 550                 555                 560 
Gly Asp Ala Ser Gln Val Ile Gly Pro Leu Thr Glu Gly Gln Arg Arg
                565                 570                 575     
Asn Val Ala Val Val Asn Ser Leu Tyr Lys Leu His Gln Ser Val Thr
            580                 585                 590         
Lys Ala Ile His Ala Leu Met Glu Asn Ala Val Gln Pro Leu Leu Thr
        595                 600                 605             
Ser Val Gly Asp Ala Ile Glu Ala Ile Ile Ile Thr Met His Gln Glu
    610                 615                 620                 
Asp Phe Ser Gly Ser Leu Ser Ser Ser Gly Lys Pro Asp Val Pro Cys
625                 630                 635                 640 
Ser Leu Tyr Met Lys Glu Leu Gln Gly Phe Ile Ala Arg Val Met Ser
                645                 650                 655     
Asp Tyr Phe Lys His Phe Glu Cys Leu Asp Phe Val Phe Asp Asn Thr
            660                 665                 670         
Glu Ala Ile Ala Gln Arg Ala Val Glu Leu Phe Ile Arg His Ala Ser
        675                 680                 685             
Leu Ile Arg Pro Leu Gly Glu Gly Gly Lys Met Arg Leu Ala Ala Asp
    690                 695                 700                 
Phe Ala Gln Met Glu Leu Ala Val Gly Pro Phe Cys Arg Arg Val Ser
705                 710                 715                 720 
Asp Leu Gly Lys Ser Tyr Arg Met Leu Arg Ser Phe Arg Pro Leu Leu
                725                 730                 735     
Phe Gln Ala Ser Glu His Val Ala Ser Ser Pro Ala Leu Gly Asp Val
            740                 745                 750         
Ile Pro Phe Ser Ile Ile Ile Gln Phe Leu Phe Thr Arg Ala Pro Ala
        755                 760                 765             
Glu Leu Lys Ser Pro Phe Gln Arg Ala Glu Trp Ser His Thr Arg Phe
    770                 775                 780                 
Ser Gln Trp Leu Asp Asp His Pro Ser Glu Lys Asp Arg Leu Leu Leu
785                 790                 795                 800 
Ile Arg Gly Ala Leu Glu Ala Tyr Val Gln Ser Val Arg Ser Arg Glu
                805                 810                 815     
Gly Lys Glu Phe Ala Pro Val Tyr Pro Ile Met Val Gln Leu Leu Gln
            820                 825                 830         
Lys Ala Met Ser Ala Leu Gln
        835                 


<210> 686
<211> 227
<212> PRT
<213> Homo sapiens

<400> 686
Met Gly Gly Lys Leu Ser Lys Lys Lys Lys Gly Tyr Asn Val Asn Asp
 1               5                  10                  15      
Glu Lys Ala Lys Glu Lys Asp Lys Lys Ala Glu Gly Ala Ala Thr Glu
            20                  25                  30          
Glu Glu Gly Thr Pro Lys Glu Ser Glu Pro Gln Ala Pro Ala Glu Pro
        35                  40                  45              
Ala Glu Ala Lys Glu Gly Lys Glu Lys Pro Asp Gln Asp Ala Glu Gly
    50                  55                  60                  
Lys Ala Glu Glu Lys Glu Gly Glu Lys Asp Ala Ala Ala Ala Lys Glu
65                  70                  75                  80  
Glu Ala Pro Lys Ala Glu Pro Glu Lys Thr Glu Gly Ala Ala Glu Ala
                85                  90                  95      
Lys Ala Glu Pro Pro Lys Ala Pro Glu Gln Glu Gln Ala Ala Pro Gly
            100                 105                 110         
Pro Leu Arg Gly Gly Glu Ala Pro Lys Ala Ala Glu Ala Ala Ala Gly
        115                 120                 125             
Pro Arg Pro Arg Ala Ala Pro Ala Ala Gly Glu Glu Pro Ser Lys Glu
    130                 135                 140                 
Glu Gly Glu Pro Lys Lys Thr Glu Ala Pro Ala Ala Pro Ala Ala Gln
145                 150                 155                 160 
Glu Thr Lys Ser Asp Gly Ala Pro Ala Ser Asp Ser Lys Pro Gly Ser
                165                 170                 175     
Ser Glu Ala Ala Pro Ser Ser Lys Glu Thr Pro Ala Ala Thr Glu Ala
            180                 185                 190         
Pro Ser Ser Thr Pro Lys Ala Gln Gly Pro Ala Ala Ser Ala Glu Glu
        195                 200                 205             
Pro Lys Pro Val Glu Ala Pro Ala Ala Asn Ser Asp Gln Thr Val Thr
    210                 215                 220                 
Val Lys Glu
225         


<210> 687
<211> 758
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 595
<223> Xaa = Any Amino Acid

<400> 687
Met Ser Arg Lys Ile Ser Lys Glu Ser Lys Lys Val Asn Ile Ser Ser
 1               5                  10                  15      
Ser Leu Glu Ser Glu Asp Ile Ser Leu Glu Thr Thr Val Pro Thr Asp
            20                  25                  30          
Asp Ile Ser Ser Ser Glu Glu Arg Glu Gly Lys Val Arg Ile Thr Arg
        35                  40                  45              
Gln Leu Ile Glu Arg Lys Glu Leu Leu His Asn Ile Gln Leu Leu Lys
    50                  55                  60                  
Ile Glu Leu Ser Gln Lys Thr Met Met Ile Asp Asn Leu Lys Val Asp
65                  70                  75                  80  
Tyr Leu Thr Lys Ile Glu Glu Leu Glu Glu Lys Leu Asn Asp Ala Leu
                85                  90                  95      
His Gln Lys Gln Leu Leu Thr Leu Arg Leu Asp Asn Gln Leu Ala Phe
            100                 105                 110         
Gln Gln Lys Asp Ala Ser Lys Tyr Gln Glu Leu Met Lys Gln Glu Met
        115                 120                 125             
Glu Thr Ile Leu Leu Arg Gln Lys Gln Leu Glu Glu Thr Asn Leu Gln
    130                 135                 140                 
Leu Arg Glu Lys Ala Gly Asp Val Arg Arg Ser Leu Arg Asp Phe Glu
145                 150                 155                 160 
Leu Thr Glu Glu Gln Tyr Ile Lys Leu Lys Ala Phe Pro Glu Asp Gln
                165                 170                 175     
Leu Ser Ile Pro Glu Tyr Val Ser Val Arg Phe Tyr Glu Leu Val Asn
            180                 185                 190         
Pro Leu Arg Lys Glu Ile Cys Glu Leu Gln Val Lys Lys Asn Ile Leu
        195                 200                 205             
Ala Glu Glu Leu Ser Thr Asn Lys Asn Gln Leu Lys Gln Leu Thr Glu
    210                 215                 220                 
Thr Tyr Glu Glu Asp Arg Lys Asn Tyr Ser Glu Val Gln Ile Arg Cys
225                 230                 235                 240 
Gln Arg Leu Ala Leu Glu Leu Ala Asp Thr Lys Gln Leu Ile Gln Gln
                245                 250                 255     
Gly Asp Tyr Arg Gln Glu Asn Tyr Asp Lys Val Lys Ser Glu Arg Asp
            260                 265                 270         
Ala Leu Glu Gln Glu Val Ile Glu Leu Arg Arg Lys His Glu Ile Leu
        275                 280                 285             
Glu Ala Ser His Met Ile Gln Thr Lys Glu Arg Ser Glu Leu Ser Lys
    290                 295                 300                 
Glu Val Val Thr Leu Glu Gln Thr Val Thr Leu Leu Gln Lys Asp Lys
305                 310                 315                 320 
Glu Tyr Leu Asn Arg Gln Asn Met Glu Leu Ser Val Cys Cys Ala His
                325                 330                 335     
Glu Glu Asp Arg Leu Glu Arg Leu Gln Ala Gln Leu Glu Glu Ser Lys
            340                 345                 350         
Lys Ala Arg Glu Glu Met Tyr Glu Lys Tyr Val Ala Ser Arg Asp His
        355                 360                 365             
Tyr Lys Thr Glu Tyr Glu Asn Lys Leu His Asp Glu Leu Glu Gln Ile
    370                 375                 380                 
Arg Leu Lys Thr Asn Gln Glu Ile Asp Gln Leu Arg Asn Ala Ser Arg
385                 390                 395                 400 
Glu Met Tyr Glu Arg Glu Asn Arg Asn Leu Arg Glu Ala Arg Asp Asn
                405                 410                 415     
Ala Val Ala Glu Lys Glu Arg Ala Val Met Ala Glu Lys Asp Ala Leu
            420                 425                 430         
Glu Lys His Asp Gln Leu Leu Asp Arg Tyr Arg Glu Leu Gln Leu Ser
        435                 440                 445             
Thr Glu Ser Lys Val Thr Glu Phe Leu His Gln Ser Lys Leu Lys Ser
    450                 455                 460                 
Phe Glu Ser Glu Arg Val Gln Leu Leu Gln Glu Glu Thr Ala Arg Asn
465                 470                 475                 480 
Leu Thr Gln Cys Gln Leu Glu Cys Glu Lys Tyr Gln Lys Lys Leu Glu
                485                 490                 495     
Val Leu Thr Lys Glu Phe Tyr Ser Leu Gln Ala Ser Ser Glu Lys Arg
            500                 505                 510         
Ile Thr Glu Leu Gln Ala Gln Asn Ser Glu His Gln Ala Arg Leu Asp
        515                 520                 525             
Ile Tyr Glu Lys Leu Glu Lys Glu Leu Asp Glu Ile Ile Met Gln Thr
    530                 535                 540                 
Ala Glu Ile Glu Asn Glu Asp Glu Ala Glu Arg Val Leu Phe Ser Tyr
545                 550                 555                 560 
Gly Tyr Gly Ala Asn Val Pro Thr Thr Ala Lys Arg Arg Leu Lys Gln
                565                 570                 575     
Ser Val His Leu Ala Arg Arg Val Leu Gln Leu Glu Lys Gln Asn Ser
            580                 585                 590         
Leu Ile Xaa Lys Arg Ser Gly Thr Ser Lys Gly Pro Ser Asn Thr Ala
        595                 600                 605             
Phe Thr Arg Ser Leu Thr Glu Ala Asn Ser Leu Leu Asn Gln Thr Gln
    610                 615                 620                 
Gln Pro Tyr Arg Tyr Leu Ile Glu Ser Val Arg Gln Arg Asp Ser Lys
625                 630                 635                 640 
Ile Asp Ser Leu Thr Glu Ser Ile Ala Gln Leu Glu Lys Asp Val Ser
                645                 650                 655     
Asn Leu Asn Lys Glu Lys Ser Ala Leu Leu Gln Thr Lys Asn Gln Met
            660                 665                 670         
Ala Leu Asp Leu Glu Gln Leu Leu Asn His Arg Glu Glu Leu Ala Ala
        675                 680                 685             
Met Lys Gln Ile Leu Val Lys Met His Ser Lys His Ser Glu Asn Ser
    690                 695                 700                 
Leu Leu Leu Thr Lys Thr Glu Pro Lys His Val Thr Glu Asn Gln Lys
705                 710                 715                 720 
Ser Lys Thr Leu Asn Val Pro Lys Glu His Glu Asp Asn Ile Phe Thr
                725                 730                 735     
Pro Lys Pro Thr Leu Phe Thr Lys Lys Glu Ala Pro Glu Trp Ser Lys
            740                 745                 750         
Lys Gln Lys Met Lys Thr
        755             


<210> 688
<211> 131
<212> PRT
<213> Homo sapiens

<400> 688
Met Pro Pro Lys Gly Lys Ser Gly Ser Gly Lys Ala Gly Lys Gly Gly
 1               5                  10                  15      
Ala Ala Ser Gly Ser Asp Ser Ala Asp Lys Lys Ala Gln Gly Pro Lys
            20                  25                  30          
Gly Gly Gly Asn Ala Val Lys Val Arg His Ile Leu Cys Glu Lys His
        35                  40                  45              
Gly Lys Ile Met Glu Ala Met Glu Lys Leu Lys Ser Gly Met Arg Phe
    50                  55                  60                  
Asn Glu Val Ala Ala Gln Tyr Ser Glu Asp Lys Ala Arg Gln Gly Gly
65                  70                  75                  80  
Asp Leu Gly Trp Met Thr Arg Gly Ser Met Val Gly Pro Phe Gln Glu
                85                  90                  95      
Ala Ala Phe Ala Leu Pro Val Ser Gly Met Asp Lys Pro Val Phe Thr
            100                 105                 110         
Asp Pro Pro Val Lys Thr Lys Phe Gly Tyr His Ile Ile Met Val Glu
        115                 120                 125             
Gly Arg Lys
    130     


<210> 689
<211> 249
<212> PRT
<213> Homo sapiens

<400> 689
Met Ala Met Leu Arg Val Gln Pro Glu Ala Gln Ala Lys Val Asp Val
 1               5                  10                  15      
Phe Arg Glu Asp Leu Cys Thr Lys Thr Glu Asn Leu Leu Gly Ser Tyr
            20                  25                  30          
Phe Pro Lys Lys Ile Ser Glu Leu Asp Ala Phe Leu Lys Glu Pro Ala
        35                  40                  45              
Leu Asn Glu Ala Asn Leu Ser Asn Leu Lys Ala Pro Leu Asp Ile Pro
    50                  55                  60                  
Val Pro Asp Pro Val Lys Glu Lys Glu Lys Glu Glu Arg Lys Lys Gln
65                  70                  75                  80  
Gln Glu Lys Glu Asp Lys Asp Glu Lys Lys Lys Gly Glu Asp Glu Asp
                85                  90                  95      
Lys Gly Pro Pro Cys Gly Pro Val Asn Cys Asn Glu Lys Ile Val Val
            100                 105                 110         
Leu Leu Gln Arg Leu Lys Pro Glu Ile Lys Asp Val Ile Glu Gln Leu
        115                 120                 125             
Asn Leu Val Thr Thr Trp Leu Gln Leu Gln Ile Pro Arg Ile Glu Asp
    130                 135                 140                 
Gly Asn Asn Phe Gly Val Ala Val Gln Glu Lys Val Phe Glu Leu Met
145                 150                 155                 160 
Thr Ser Leu His Thr Lys Leu Glu Gly Phe His Thr Gln Ile Ser Lys
                165                 170                 175     
Tyr Phe Ser Glu Arg Gly Asp Ala Val Thr Lys Ala Ala Lys Gln Pro
            180                 185                 190         
His Val Gly Asp Tyr Arg Gln Leu Val His Glu Leu Asp Glu Ala Glu
        195                 200                 205             
Tyr Arg Asp Ile Arg Leu Met Val Met Glu Ile Arg Asn Ala Tyr Ala
    210                 215                 220                 
Val Leu Tyr Asp Ile Ile Leu Lys Asn Phe Glu Lys Leu Lys Lys Pro
225                 230                 235                 240 
Arg Gly Glu Thr Lys Gly Met Ile Tyr
                245                 


<210> 690
<211> 218
<212> PRT
<213> Homo sapiens

<400> 690
Met Ser Ser Gly Ala Ala Ser Gly Thr Gly Arg Gly Arg Pro Arg Gly
 1               5                  10                  15      
Gly Gly Pro Gly Pro Gly Asp Pro Pro Pro Ser Glu Thr His Lys Leu
            20                  25                  30          
Val Val Val Gly Gly Gly Gly Val Gly Lys Ser Ala Leu Thr Ile Gln
        35                  40                  45              
Phe Ile Gln Ser Tyr Phe Val Ser Asp Tyr Asp Pro Thr Ile Glu Asp
    50                  55                  60                  
Ser Tyr Thr Lys Ile Cys Ser Val Asp Gly Ile Pro Ala Arg Leu Asp
65                  70                  75                  80  
Ile Leu Asp Thr Ala Gly Gln Glu Glu Phe Gly Ala Met Arg Glu Gln
                85                  90                  95      
Tyr Met Arg Ala Gly His Gly Phe Leu Leu Val Phe Ala Ile Asn Asp
            100                 105                 110         
Arg Gln Ser Phe Asn Glu Val Gly Lys Leu Phe Thr Gln Ile Leu Arg
        115                 120                 125             
Val Lys Asp Arg Asp Asp Phe Pro Val Val Leu Val Gly Asn Lys Ala
    130                 135                 140                 
Asp Leu Glu Ser Gln Arg Gln Val Pro Arg Ser Glu Ala Ser Ala Phe
145                 150                 155                 160 
Gly Ala Ser His His Val Ala Tyr Phe Glu Ala Ser Ala Lys Leu Arg
                165                 170                 175     
Leu Asn Val Asp Glu Ala Phe Glu Gln Leu Val Arg Ala Val Arg Lys
            180                 185                 190         
Tyr Gln Glu Gln Glu Leu Pro Pro Ser Pro Pro Ser Ala Pro Arg Lys
        195                 200                 205             
Lys Gly Gly Gly Cys Pro Cys Val Leu Leu
    210                 215             


<210> 691
<211> 209
<212> PRT
<213> Homo sapiens

<400> 691
Met Glu Gly Gly Gly Gly Ser Gly Asn Lys Thr Thr Gly Gly Leu Ala
 1               5                  10                  15      
Gly Phe Phe Gly Ala Gly Gly Ala Gly Tyr Ser His Ala Asp Leu Ala
            20                  25                  30          
Gly Val Pro Leu Thr Gly Met Asn Pro Leu Ser Pro Tyr Leu Asn Val
        35                  40                  45              
Asp Pro Arg Tyr Leu Val Gln Asp Thr Asp Glu Phe Ile Leu Pro Thr
    50                  55                  60                  
Gly Ala Asn Lys Thr Arg Gly Arg Phe Glu Leu Ala Phe Phe Thr Ile
65                  70                  75                  80  
Gly Gly Cys Cys Met Thr Gly Ala Ala Phe Gly Ala Met Asn Gly Leu
                85                  90                  95      
Arg Leu Gly Leu Lys Glu Thr Gln Asn Met Ala Trp Ser Lys Pro Arg
            100                 105                 110         
Asn Val Gln Ile Leu Asn Met Val Thr Arg Gln Gly Ala Leu Trp Ala
        115                 120                 125             
Asn Thr Leu Gly Ser Leu Ala Leu Leu Tyr Ser Ala Phe Gly Val Ile
    130                 135                 140                 
Ile Glu Lys Thr Arg Gly Ala Glu Asp Asp Leu Asn Thr Val Ala Ala
145                 150                 155                 160 
Gly Thr Met Thr Gly Met Leu Tyr Lys Cys Thr Gly Gly Leu Arg Gly
                165                 170                 175     
Ile Ala Arg Gly Gly Leu Thr Gly Leu Thr Leu Thr Ser Leu Tyr Ala
            180                 185                 190         
Leu Tyr Asn Asn Trp Glu His Met Lys Gly Ser Leu Leu Gln Gln Ser
        195                 200                 205             
Leu
    


<210> 692
<211> 1591
<212> PRT
<213> Homo sapiens

<400> 692
Met Ser Leu Leu Cys Val Arg Val Lys Arg Ala Lys Phe Gln Gly Ser
 1               5                  10                  15      
Pro Asp Lys Phe Asn Thr Tyr Val Thr Leu Lys Val Gln Asn Val Lys
            20                  25                  30          
Ser Thr Thr Val Ala Val Arg Gly Asp Gln Pro Ser Trp Glu Gln Asp
        35                  40                  45              
Phe Met Phe Glu Ile Ser Arg Leu Asp Leu Gly Leu Ser Val Glu Val
    50                  55                  60                  
Trp Asn Lys Gly Leu Ile Trp Asp Thr Met Val Gly Thr Val Trp Ile
65                  70                  75                  80  
Ala Leu Lys Thr Ile Arg Gln Ser Asp Glu Glu Gly Pro Gly Glu Trp
                85                  90                  95      
Ser Thr Leu Glu Ala Glu Thr Leu Met Lys Asp Asp Glu Ile Cys Gly
            100                 105                 110         
Thr Arg Asn Pro Thr Pro His Lys Ile Leu Leu Asp Thr Arg Phe Glu
        115                 120                 125             
Leu Pro Phe Asp Ile Pro Glu Glu Glu Ala Arg Tyr Trp Thr Tyr Lys
    130                 135                 140                 
Trp Glu Gln Ile Asn Ala Leu Gly Ala Asp Asn Glu Tyr Ser Ser Gln
145                 150                 155                 160 
Glu Glu Ser Gln Arg Lys Pro Leu Pro Thr Ala Ala Ala Gln Cys Ser
                165                 170                 175     
Phe Glu Asp Pro Asp Ser Ala Val Asp Asp Arg Asp Ser Asp Tyr Arg
            180                 185                 190         
Ser Glu Thr Ser Asn Ser Phe Pro Pro Pro Tyr His Thr Ala Ser Gln
        195                 200                 205             
Pro Asn Ala Ser Val His Gln Phe Pro Val Pro Val Arg Ser Pro Gln
    210                 215                 220                 
Gln Leu Leu Leu Gln Gly Ser Ser Arg Asp Ser Cys Asn Asp Ser Met
225                 230                 235                 240 
Gln Ser Tyr Asp Leu Asp Tyr Pro Glu Arg Arg Ala Ile Ser Pro Thr
                245                 250                 255     
Ser Ser Ser Arg Tyr Gly Ser Ser Cys Asn Val Ser Gln Gly Ser Ser
            260                 265                 270         
Gln Leu Ser Glu Leu Asp Gln Tyr His Glu Gln Asp Asp Asp His Arg
        275                 280                 285             
Glu Thr Asp Ser Ile His Ser Cys His Ser Ser His Ser Leu Ser Arg
    290                 295                 300                 
Asp Gly Gln Ala Gly Phe Gly Glu Gln Glu Lys Pro Leu Glu Val Thr
305                 310                 315                 320 
Gly Gln Ala Glu Lys Glu Ala Ala Cys Glu Pro Lys Glu Met Lys Glu
                325                 330                 335     
Asp Ala Thr Thr His Pro Pro Pro Asp Leu Val Leu Gln Lys Asp His
            340                 345                 350         
Phe Leu Gly Pro Gln Glu Ser Phe Pro Glu Glu Asn Ala Ser Ser Pro
        355                 360                 365             
Phe Thr Gln Ala Arg Ala His Trp Ile Arg Ala Val Thr Lys Val Arg
    370                 375                 380                 
Leu Gln Leu Gln Glu Ile Pro Asp Asp Gly Asp Pro Ser Leu Pro Gln
385                 390                 395                 400 
Trp Leu Pro Glu Gly Pro Ala Gly Gly Leu Tyr Gly Ile Asp Ser Met
                405                 410                 415     
Pro Asp Leu Arg Arg Lys Lys Pro Leu Pro Leu Val Ser Asp Leu Ser
            420                 425                 430         
Leu Val Gln Ser Arg Lys Ala Gly Ile Thr Ser Ala Met Ala Thr Arg
        435                 440                 445             
Thr Ser Leu Lys Asp Glu Glu Leu Lys Ser His Val Tyr Lys Lys Thr
    450                 455                 460                 
Leu Gln Ala Leu Ile Tyr Pro Ile Ser Cys Thr Thr Pro His Asn Phe
465                 470                 475                 480 
Glu Val Trp Thr Ala Thr Thr Pro Thr Tyr Cys Tyr Glu Cys Glu Gly
                485                 490                 495     
Leu Leu Trp Gly Ile Ala Arg Gln Gly Met Arg Cys Ser Glu Cys Gly
            500                 505                 510         
Val Lys Cys His Glu Lys Cys Gln Asp Leu Leu Asn Ala Asp Cys Leu
        515                 520                 525             
Gln Arg Ala Ala Glu Lys Ser Cys Lys His Gly Ala Glu Asp Arg Thr
    530                 535                 540                 
Gln Asn Ile Ile Met Ala Met Lys Asp Arg Met Lys Ile Arg Glu Arg
545                 550                 555                 560 
Asn Lys Pro Glu Ile Phe Glu Val Ile Arg Asp Val Phe Thr Val Asn
                565                 570                 575     
Lys Ala Ala His Val Gln Gln Met Lys Thr Val Lys Gln Ser Val Leu
            580                 585                 590         
Asp Gly Thr Ser Lys Trp Ser Ala Lys Ile Thr Ile Thr Val Val Cys
        595                 600                 605             
Ala Gln Gly Leu Gln Ala Lys Asp Lys Thr Gly Ser Ser Asp Pro Tyr
    610                 615                 620                 
Val Thr Val Gln Val Ser Lys Thr Lys Lys Arg Thr Lys Thr Ile Phe
625                 630                 635                 640 
Gly Asn Leu Asn Pro Val Trp Glu Glu Lys Phe His Phe Glu Cys His
                645                 650                 655     
Asn Ser Ser Asp Arg Ile Lys Val Arg Val Trp Asp Glu Asp Asp Asp
            660                 665                 670         
Ile Lys Ser Arg Val Lys Gln Arg Leu Lys Arg Glu Ser Asp Asp Phe
        675                 680                 685             
Leu Gly Gln Thr Ile Ile Glu Val Arg Thr Leu Ser Gly Glu Met Asp
    690                 695                 700                 
Val Trp Tyr Asn Leu Glu Lys Arg Thr Asp Lys Ser Ala Val Ser Gly
705                 710                 715                 720 
Ala Ile Arg Leu Gln Ile Ser Val Glu Ile Lys Gly Glu Glu Lys Val
                725                 730                 735     
Ala Pro Tyr His Val Gln Tyr Thr Cys Leu His Glu Asn Leu Phe His
            740                 745                 750         
Tyr Leu Thr Asp Ile Gln Gly Ser Gly Gly Val Arg Ile Pro Glu Ala
        755                 760                 765             
Arg Gly Asp Asp Ala Trp Lys Val Tyr Phe Asp Glu Thr Ala Gln Glu
    770                 775                 780                 
Ile Val Asp Glu Phe Ala Met Arg Tyr Gly Ile Glu Ser Ile Tyr Gln
785                 790                 795                 800 
Ala Met Thr His Phe Ala Cys Leu Ser Ser Lys Tyr Met Cys Pro Gly
                805                 810                 815     
Val Pro Ala Val Met Ser Thr Leu Leu Ala Asn Ile Asn Ala Tyr Tyr
            820                 825                 830         
Ala His Thr Thr Ala Ser Thr Asn Val Ser Ala Ser Asp Arg Phe Ala
        835                 840                 845             
Ala Ser Asn Phe Gly Lys Glu Arg Phe Val Lys Leu Leu Asp Gln Leu
    850                 855                 860                 
His Asn Ser Leu Arg Ile Asp Leu Ser Thr Tyr Arg Asn Asn Phe Pro
865                 870                 875                 880 
Ala Gly Ser Pro Glu Arg Leu Gln Asp Leu Lys Ser Thr Val Asp Leu
                885                 890                 895     
Leu Thr Ser Ile Thr Phe Phe Arg Met Lys Val Gln Glu Leu Gln Ser
            900                 905                 910         
Pro Pro Arg Ala Ser Gln Val Val Lys Asp Cys Val Lys Ala Cys Leu
        915                 920                 925             
Asn Ser Thr Tyr Glu Tyr Ile Phe Asn Asn Cys His Asp Leu Tyr Ser
    930                 935                 940                 
Arg Gln Tyr Gln Leu Lys Gln Glu Leu Pro Pro Glu Glu Gln Gly Pro
945                 950                 955                 960 
Ser Ile Arg Asn Leu Asp Phe Trp Pro Lys Leu Ile Thr Leu Ile Val
                965                 970                 975     
Ser Ile Ile Glu Glu Asp Lys Asn Ser Tyr Thr Pro Val Leu Asn Gln
            980                 985                 990         
Phe Pro Gln Glu Leu Asn Val Gly Lys Val Ser Ala Glu Val Met Trp
        995                 1000                1005            
His Leu Phe Ala Gln Asp Met Lys Tyr Ala Leu Glu Glu His Glu Lys
    1010                1015                1020                
Asp His Leu Cys Lys Ser Ala Asp Tyr Met Asn Leu His Phe Lys Val
1025                1030                1035                1040
Lys Trp Leu His Asn Glu Tyr Val Arg Asp Leu Pro Val Leu Gln Gly
                1045                1050                1055    
Gln Val Pro Glu Tyr Pro Ala Trp Phe Glu Gln Phe Val Leu Gln Trp
            1060                1065                1070        
Leu Asp Glu Asn Glu Asp Val Ser Leu Glu Phe Leu Arg Gly Ala Leu
        1075                1080                1085            
Glu Arg Asp Lys Lys Asp Gly Phe Gln Gln Thr Ser Glu His Ala Leu
    1090                1095                1100                
Phe Ser Cys Ser Val Val Asp Val Phe Thr Gln Leu Asn Gln Ser Phe
1105                1110                1115                1120
Glu Ile Ile Arg Lys Leu Glu Cys Pro Asp Pro Ser Ile Leu Ala His
                1125                1130                1135    
Tyr Met Arg Arg Phe Ala Lys Thr Ile Gly Lys Val Leu Met Gln Tyr
            1140                1145                1150        
Ala Asp Ile Leu Ser Lys Asp Phe Pro Ala Tyr Cys Thr Lys Glu Lys
        1155                1160                1165            
Leu Pro Cys Ile Leu Met Asn Asn Val Gln Gln Leu Arg Val Gln Leu
    1170                1175                1180                
Glu Lys Met Phe Glu Ala Met Gly Gly Lys Glu Leu Asp Leu Glu Ala
1185                1190                1195                1200
Ala Asp Ser Leu Lys Glu Pro Gln Val Lys Leu Asn Thr Val Leu Asp
                1205                1210                1215    
Glu Leu Ser Met Val Phe Gly Asn Ser Phe Gln Val Arg Ile Asp Glu
            1220                1225                1230        
Cys Val Arg Gln Met Ala Asp Ile Leu Gly Gln Val Arg Gly Thr Gly
        1235                1240                1245            
Asn Ala Ser Pro Asp Ala Arg Ala Ser Ala Ala Gln Asp Ala Asp Ser
    1250                1255                1260                
Val Leu Arg Pro Leu Met Asp Phe Leu Asp Gly Asn Leu Thr Leu Phe
1265                1270                1275                1280
Ala Thr Val Cys Glu Lys Thr Val Leu Lys Arg Val Leu Lys Glu Leu
                1285                1290                1295    
Trp Arg Val Val Met Asn Thr Met Glu Arg Met Ile Val Leu Pro Pro
            1300                1305                1310        
Leu Thr Asp Gln Thr Gly Thr Gln Leu Ile Phe Thr Ala Ala Lys Glu
        1315                1320                1325            
Leu Ser His Leu Ser Lys Leu Lys Asp His Met Val Arg Glu Glu Thr
    1330                1335                1340                
Arg Asn Leu Thr Pro Lys Gln Cys Ala Val Leu Asp Leu Ala Leu Asp
1345                1350                1355                1360
Thr Ile Lys Gln Tyr Phe His Ala Gly Gly Asn Gly Leu Lys Lys Thr
                1365                1370                1375    
Phe Leu Glu Lys Ser Pro Asp Leu Gln Ser Leu Arg Tyr Ala Leu Ser
            1380                1385                1390        
Leu Tyr Thr Gln Thr Thr Asp Thr Leu Ile Lys Arg Phe Val Arg Ser
        1395                1400                1405            
Gln Thr Thr Gln Gly Ser Gly Val Asp Asp Pro Val Gly Glu Val Ser
    1410                1415                1420                
Ile Gln Val Asp Leu Phe Thr His Pro Gly Thr Gly Glu His Lys Val
1425                1430                1435                1440
Thr Val Lys Val Val Ala Ala Asn Asp Leu Lys Trp Gln Thr Ala Gly
                1445                1450                1455    
Met Phe Arg Pro Phe Val Glu Val Thr Met Val Gly Pro His Gln Ser
            1460                1465                1470        
Asp Lys Lys Arg Lys Phe Thr Thr Lys Ser Lys Ser Asn Asn Trp Ala
        1475                1480                1485            
Pro Lys Tyr Asn Glu Thr Phe His Leu Leu Leu Gly Asn Glu Glu Gly
    1490                1495                1500                
Pro Glu Ser Tyr Glu Leu Gln Ile Cys Val Lys Asp Tyr Cys Phe Ala
1505                1510                1515                1520
Arg Glu Asp Arg Val Leu Gly Leu Ala Val Met Pro Leu Arg Asp Val
                1525                1530                1535    
Thr Ala Lys Gly Ser Cys Ala Cys Trp Cys Pro Leu Gly Arg Lys Ile
            1540                1545                1550        
His Met Asp Glu Thr Gly Leu Thr Ile Leu Arg Ile Leu Ser Gln Arg
        1555                1560                1565            
Ser Asn Asp Glu Val Ala Arg Glu Phe Val Lys Leu Lys Ser Glu Ser
    1570                1575                1580                
Arg Ser Thr Glu Glu Gly Ser
1585                1590    


<210> 693
<211> 111
<212> PRT
<213> Homo sapiens

<400> 693
Met Ala Gly Lys Gln Ala Val Ser Ala Ser Gly Lys Trp Leu Asp Gly
 1               5                  10                  15      
Ile Arg Lys Trp Tyr Tyr Asn Ala Ala Gly Phe Asn Lys Leu Gly Leu
            20                  25                  30          
Met Arg Asp Asp Thr Ile Tyr Glu Asp Glu Asp Val Lys Glu Ala Ile
        35                  40                  45              
Arg Arg Leu Pro Glu Asn Leu Tyr Asn Asp Arg Met Phe Arg Ile Lys
    50                  55                  60                  
Arg Ala Leu Asp Leu Asn Leu Lys His Gln Ile Leu Pro Lys Glu Gln
65                  70                  75                  80  
Trp Thr Lys Tyr Glu Glu Glu Asn Phe Tyr Leu Glu Pro Tyr Leu Lys
                85                  90                  95      
Glu Val Ile Arg Glu Arg Lys Glu Arg Glu Glu Trp Ala Lys Lys
            100                 105                 110     


<210> 694
<211> 394
<212> PRT
<213> Homo sapiens

<400> 694
Met Asn Thr Asn Ser Lys Glu Val Leu Ser Leu Gly Val Gln Val Pro
 1               5                  10                  15      
Glu Ala Trp Glu Glu Leu Leu Thr Met Lys Val Glu Ala Lys Ser His
            20                  25                  30          
Leu Gln Trp Gln Glu Ser Arg Leu Lys Arg Ser Asn Pro Leu Ala Arg
        35                  40                  45              
Glu Ile Phe Arg Arg His Phe Arg Gln Leu Cys Tyr Gln Glu Thr Pro
    50                  55                  60                  
Gly Pro Arg Glu Ala Leu Thr Arg Leu Gln Glu Leu Cys Tyr Gln Trp
65                  70                  75                  80  
Leu Arg Pro His Val Ser Thr Lys Glu Gln Ile Leu Asp Leu Leu Val
                85                  90                  95      
Leu Glu Gln Phe Leu Ser Ile Leu Pro Lys Glu Leu Gln Gly Trp Val
            100                 105                 110         
Arg Glu His Cys Pro Glu Ser Gly Glu Glu Ala Val Ile Leu Leu Glu
        115                 120                 125             
Asp Leu Glu Arg Glu Leu Asp Glu Pro Gln His Glu Met Val Ala His
    130                 135                 140                 
Arg His Arg Gln Glu Val Leu Cys Lys Glu Met Val Pro Leu Ala Glu
145                 150                 155                 160 
Gln Thr Pro Leu Thr Leu Gln Ser Gln Pro Lys Glu Pro Gln Leu Thr
                165                 170                 175     
Cys Asp Ser Ala Gln Lys Cys His Ser Ile Gly Glu Thr Asp Glu Val
            180                 185                 190         
Thr Lys Thr Glu Asp Arg Glu Leu Val Leu Arg Lys Asp Cys Pro Lys
        195                 200                 205             
Ile Val Glu Pro His Gly Lys Met Phe Asn Glu Gln Thr Trp Glu Val
    210                 215                 220                 
Ser Gln Gln Asp Pro Ser His Gly Glu Val Gly Glu His Lys Asp Arg
225                 230                 235                 240 
Ile Glu Arg Gln Trp Gly Asn Leu Leu Gly Glu Gly Gln His Lys Cys
                245                 250                 255     
Asp Glu Cys Gly Lys Ser Phe Thr Gln Ser Ser Gly Leu Ile Arg His
            260                 265                 270         
Gln Arg Ile His Thr Gly Glu Arg Pro Tyr Glu Cys Asn Glu Cys Gly
        275                 280                 285             
Lys Ala Phe Ser Arg Ser Ser Gly Leu Phe Asn His Arg Gly Ile His
    290                 295                 300                 
Asn Ile Gln Lys Arg Tyr His Cys Lys Glu Cys Gly Lys Val Phe Ser
305                 310                 315                 320 
Gln Ser Ala Gly Leu Ile Gln His Gln Arg Ile His Lys Gly Glu Lys
                325                 330                 335     
Pro Tyr Gln Cys Ser Gln Cys Ser Lys Ser Tyr Ser Arg Arg Ser Phe
            340                 345                 350         
Leu Ile Glu His Gln Arg Ser His Thr Gly Glu Arg Pro His Gln Cys
        355                 360                 365             
Ile Glu Cys Gly Lys Ser Phe Asn Arg His Cys Asn Leu Ile Arg His
    370                 375                 380                 
Gln Lys Ile His Thr Val Ala Glu Leu Val
385                 390                 


<210> 695
<211> 192
<212> PRT
<213> Homo sapiens

<400> 695
Tyr Lys Asp Leu Glu Ile Gln Met Lys Lys Asp Glu Lys Met Asn Ile
 1               5                  10                  15      
Ser Gly Lys Lys Asn Val Asp Ser Asp Arg Leu Gly Met Gly Phe Gly
            20                  25                  30          
Asn Cys Arg Ser Val Ile Ser His Ser Val Thr Ser Asp Met Gln Thr
        35                  40                  45              
Ile Glu Gln Glu Ser Pro Ile Met Ala Lys Pro Arg Lys Lys Tyr Asn
    50                  55                  60                  
Asp Asp Ser Asp Asp Ser Tyr Phe Thr Ser Ser Ser Ser Tyr Phe Asp
65                  70                  75                  80  
Glu Pro Val Glu Leu Arg Ser Ser Ser Phe Ser Ser Trp Asp Asp Ser
                85                  90                  95      
Ser Asp Ser Tyr Trp Lys Lys Glu Thr Ser Lys Asp Thr Glu Thr Val
            100                 105                 110         
Leu Lys Thr Thr Gly Tyr Ser Asp Arg Pro Thr Ala Arg Arg Lys Pro
        115                 120                 125             
Asp Tyr Glu Pro Val Glu Asn Thr Asp Glu Ala Gln Lys Lys Phe Gly
    130                 135                 140                 
Asn Val Lys Ala Ile Ser Ser Asp Met Tyr Phe Gly Arg Gln Ser Gln
145                 150                 155                 160 
Ala Asp Tyr Glu Thr Arg Ala Arg Leu Glu Arg Leu Ser Ala Ser Ser
                165                 170                 175     
Ser Ile Ser Ser Ala Asp Leu Phe Glu Glu Pro Arg Lys Gln Pro Ala
            180                 185                 190         


<210> 696
<211> 761
<212> PRT
<213> Homo sapiens

<400> 696
Gly Gly Phe Ala Val Gln His Gln Gly Pro Cys Ala Phe Tyr Cys Asp
 1               5                  10                  15      
Leu Pro Val Gly Thr Leu Ser Pro Ser Arg Ser Ser Met Glu Arg Arg
            20                  25                  30          
Ser Glu Ser Pro Cys Leu Arg Asp Ser Pro Asp Arg Arg Ser Gly Ser
        35                  40                  45              
Pro Asp Val Lys Gly Pro Pro Pro Val Lys Val Ala Arg Leu Glu Gln
    50                  55                  60                  
Asn Gly Ser Pro Met Gly Ala Arg Gly Arg Pro Asn Gly Ala Val Ala
65                  70                  75                  80  
Lys Ala Val Gly Gly Leu Met Ile Pro Val Phe Cys Val Val Glu Gln
                85                  90                  95      
Leu Asp Gly Ser Leu Glu Tyr Asp Asn Arg Glu Glu His Ala Glu Phe
            100                 105                 110         
Val Leu Val Arg Lys Asp Val Leu Phe Ser Gln Leu Val Glu Thr Ala
        115                 120                 125             
Leu Leu Ala Leu Gly Tyr Ser His Ser Ser Ala Ala Gln Ala Gln Gly
    130                 135                 140                 
Ile Ile Lys Leu Gly Arg Trp Asn Pro Leu Pro Leu Ser Tyr Val Thr
145                 150                 155                 160 
Asp Ala Pro Asp Ala Thr Val Ala Asp Met Leu Gln Asp Val Tyr His
                165                 170                 175     
Val Val Thr Leu Lys Ile Gln Leu Gln Ser Cys Ser Lys Leu Glu Asp
            180                 185                 190         
Leu Pro Ala Glu Gln Trp Asn His Ala Thr Val Arg Asn Ala Leu Lys
        195                 200                 205             
Glu Leu Leu Lys Glu Met Asn Gln Ser Thr Leu Ala Lys Glu Cys Pro
    210                 215                 220                 
Leu Ser Gln Ser Met Ile Ser Ser Ile Val Asn Ser Thr Tyr Tyr Ala
225                 230                 235                 240 
Asn Val Ser Ala Thr Lys Cys Gln Glu Phe Gly Arg Trp Tyr Lys Lys
                245                 250                 255     
Tyr Lys Lys Ile Lys Val Glu Arg Val Glu Arg Glu Asn Leu Ser Asp
            260                 265                 270         
Tyr Cys Val Leu Gly Gln Arg Pro Met His Leu Pro Asn Met Asn Gln
        275                 280                 285             
Leu Ala Ser Leu Gly Lys Thr Asn Glu Gln Ser Pro His Ser Gln Ile
    290                 295                 300                 
His His Ser Thr Pro Ile Arg Asn Gln Val Pro Ala Leu Gln Pro Ile
305                 310                 315                 320 
Met Ser Pro Gly Leu Leu Ser Pro Gln Leu Ser Pro Gln Leu Val Arg
                325                 330                 335     
Gln Gln Ile Ala Met Ala His Leu Ile Asn Gln Gln Ile Ala Val Ser
            340                 345                 350         
Arg Leu Leu Ala His Gln His Pro Gln Ala Ile Asn Gln Gln Phe Leu
        355                 360                 365             
Asn His Pro Pro Ile Pro Arg Ala Val Lys Pro Glu Pro Thr Asn Ser
    370                 375                 380                 
Ser Val Glu Val Ser Pro Asp Ile Tyr Gln Gln Val Arg Asp Glu Leu
385                 390                 395                 400 
Lys Arg Ala Ser Val Ser Gln Ala Val Phe Ala Arg Val Ala Phe Asn
                405                 410                 415     
Arg Thr Gln Gly Leu Leu Ser Glu Ile Leu Arg Lys Glu Glu Asp Pro
            420                 425                 430         
Arg Thr Ala Ser Gln Ser Leu Leu Val Asn Leu Arg Ala Met Gln Asn
        435                 440                 445             
Phe Leu Asn Leu Pro Glu Val Glu Arg Asp Arg Ile Tyr Gln Asp Glu
    450                 455                 460                 
Arg Glu Arg Ser Met Asn Pro Asn Val Ser Met Val Ser Ser Ala Ser
465                 470                 475                 480 
Ser Ser Pro Ser Ser Ser Arg Thr Pro Gln Ala Lys Thr Ser Thr Pro
                485                 490                 495     
Thr Thr Asp Leu Pro Ile Lys Val Asp Gly Ala Asn Ile Asn Ile Thr
            500                 505                 510         
Ala Ala Ile Tyr Asp Glu Ile Gln Gln Glu Met Lys Arg Ala Lys Val
        515                 520                 525             
Ser Gln Ala Leu Phe Ala Lys Val Ala Ala Asn Lys Ser Gln Gly Trp
    530                 535                 540                 
Leu Cys Glu Leu Leu Arg Trp Lys Glu Asn Pro Ser Pro Glu Asn Arg
545                 550                 555                 560 
Thr Leu Trp Glu Asn Leu Cys Thr Ile Arg Arg Phe Leu Asn Leu Pro
                565                 570                 575     
Gln His Glu Arg Asp Val Ile Tyr Glu Glu Glu Ser Arg His His His
            580                 585                 590         
Ser Glu Arg Met Gln His Val Val Gln Leu Pro Pro Glu Pro Val Gln
        595                 600                 605             
Val Leu His Arg Gln Gln Ser Gln Pro Ala Lys Glu Ser Ser Pro Pro
    610                 615                 620                 
Arg Glu Glu Ala Pro Pro Pro Pro Pro Pro Thr Glu Asp Ser Cys Ala
625                 630                 635                 640 
Lys Lys Pro Arg Ser Arg Thr Lys Ile Ser Leu Glu Ala Leu Gly Ile
                645                 650                 655     
Leu Gln Ser Phe Ile His Asp Val Gly Leu Tyr Pro Asp Gln Glu Ala
            660                 665                 670         
Ile His Thr Leu Ser Ala Gln Leu Asp Leu Pro Lys His Thr Ile Ile
        675                 680                 685             
Lys Phe Phe Gln Asn Gln Arg Tyr His Val Lys His His Gly Lys Leu
    690                 695                 700                 
Lys Glu His Leu Gly Ser Ala Val Asp Val Ala Glu Tyr Lys Asp Glu
705                 710                 715                 720 
Glu Leu Leu Thr Glu Ser Glu Glu Asn Asp Ser Glu Glu Gly Ser Glu
                725                 730                 735     
Glu Met Tyr Lys Val Glu Ala Glu Glu Glu Asn Ala Asp Lys Ser Lys
            740                 745                 750         
Ala Ala Pro Ala Glu Ile Asp Gln Arg
        755                 760     


<210> 697
<211> 1957
<212> PRT
<213> Homo sapiens

<400> 697
Leu Pro Pro Val Thr Met Ser Gly Lys Tyr Ile Met Glu Glu His Asp
 1               5                  10                  15      
Ser Tyr Ser Asp Gln Val Trp Ser Ile Asp Glu Leu Pro Ser Lys Gln
            20                  25                  30          
Gly Tyr Tyr Leu Gln Gly Asn Tyr Leu Arg Cys Val Ala Glu Val Gly
        35                  40                  45              
Ser Phe Glu His Asn Leu Thr Thr Asp Leu Leu Asn His Leu Val Phe
    50                  55                  60                  
Val Gln Lys Val Phe Met Lys Glu Val Asn Glu Val Ile Gln Lys Val
65                  70                  75                  80  
Ser Gly Gly Glu Gln Pro Ile Pro Leu Trp Asn Glu His Asp Gly Thr
                85                  90                  95      
Ala Asp Gly Asp Lys Pro Lys Ile Leu Leu Tyr Ser Leu Asn Leu Gln
            100                 105                 110         
Phe Lys Gly Ile Gln Val Thr Ala Thr Thr Pro Ser Met Arg Ala Val
        115                 120                 125             
Arg Phe Glu Thr Gly Leu Ile Glu Leu Glu Leu Ser Asn Arg Leu Gln
    130                 135                 140                 
Thr Lys Ala Ser Pro Gly Ser Ser Ser Tyr Leu Lys Leu Phe Gly Lys
145                 150                 155                 160 
Cys Gln Val Asp Leu Asn Leu Ala Leu Gly Gln Ile Val Lys His Gln
                165                 170                 175     
Val Tyr Glu Glu Ala Gly Ser Asp Phe His Gln Val Ala Tyr Phe Lys
            180                 185                 190         
Thr Arg Ile Gly Leu Arg Asn Ala Leu Arg Glu Glu Ile Ser Gly Ser
        195                 200                 205             
Ser Asp Arg Glu Ala Val Leu Ile Thr Leu Asn Arg Pro Ile Val Tyr
    210                 215                 220                 
Ala Gln Pro Val Ala Phe Asp Arg Ala Val Leu Phe Trp Leu Asn Tyr
225                 230                 235                 240 
Lys Ala Ala Tyr Asp Asn Trp Asn Glu Gln Arg Met Ala Leu His Lys
                245                 250                 255     
Asp Ile His Met Ala Thr Lys Glu Val Val Asp Met Leu Pro Gly Ile
            260                 265                 270         
Gln Gln Thr Ser Ala Gln Ala Phe Gly Thr Leu Phe Leu Gln Leu Thr
        275                 280                 285             
Val Asn Asp Leu Gly Ile Cys Leu Pro Ile Thr Asn Thr Ala Gln Ser
    290                 295                 300                 
Asn His Thr Gly Asp Leu Asp Thr Gly Ser Ala Leu Val Leu Thr Ile
305                 310                 315                 320 
Glu Ser Thr Leu Ile Thr Ala Cys Ser Ser Glu Ser Leu Val Ser Lys
                325                 330                 335     
Gly His Phe Lys Asn Phe Cys Ile Arg Phe Ala Asp Gly Phe Glu Thr
            340                 345                 350         
Ser Trp Asp Asp Trp Lys Pro Glu Ile His Gly Asp Leu Val Met Asn
        355                 360                 365             
Ala Cys Val Val Pro Asp Gly Thr Tyr Glu Val Cys Ser Arg Thr Thr
    370                 375                 380                 
Gly Gln Ala Ala Ala Glu Ser Ser Ser Ala Gly Thr Trp Thr Leu Asn
385                 390                 395                 400 
Val Leu Trp Lys Met Cys Gly Ile Asp Val His Met Asp Pro Asn Ile
                405                 410                 415     
Gly Lys Arg Leu Asn Ala Leu Gly Asn Thr Leu Thr Thr Leu Thr Gly
            420                 425                 430         
Glu Glu Asp Ile Asp Asp Ile Ala Asp Leu Asn Ser Val Asn Ile Ala
        435                 440                 445             
Asp Leu Ser Asp Glu Asp Glu Val Asp Thr Met Ser Pro Thr Ile His
    450                 455                 460                 
Thr Glu Ala Thr Asp Tyr Arg Arg Gln Ala Ala Ser Ala Ser Gln Pro
465                 470                 475                 480 
Gly Glu Leu Arg Gly Arg Lys Ile Met Lys Arg Ile Val Asp Ile Arg
                485                 490                 495     
Glu Leu Asn Glu Gln Ala Lys Val Ile Asp Asp Leu Lys Lys Leu Gly
            500                 505                 510         
Ala Ser Glu Gly Thr Ile Asn Gln Glu Ile Gln Arg Tyr Gln Gln Leu
        515                 520                 525             
Glu Ser Val Ala Val Asn Asp Ile Arg Arg Asp Val Arg Lys Lys Leu
    530                 535                 540                 
Arg Arg Ser Ser Met Arg Ala Ala Ser Leu Lys Asp Lys Trp Gly Leu
545                 550                 555                 560 
Ser Tyr Lys Pro Ser Tyr Ser Arg Ser Lys Ser Ile Ser Ala Ser Gly
                565                 570                 575     
Arg Pro Pro Leu Lys Arg Met Glu Arg Ala Ser Ser Arg Val Gly Glu
            580                 585                 590         
Thr Glu Glu Leu Pro Glu Ile Arg Val Asp Ala Ala Ser Pro Gly Pro
        595                 600                 605             
Arg Val Thr Phe Asn Ile Gln Asp Thr Phe Pro Glu Glu Thr Glu Leu
    610                 615                 620                 
Asp Leu Leu Ser Val Thr Ile Glu Gly Pro Ser His Tyr Ser Ser Asn
625                 630                 635                 640 
Ser Glu Gly Ser Cys Ser Val Phe Ser Ser Pro Lys Thr Pro Gly Gly
                645                 650                 655     
Phe Ser Pro Gly Ile Pro Phe Gln Thr Glu Glu Gly Arg Arg Asp Asp
            660                 665                 670         
Ser Leu Ser Ser Thr Ser Glu Asp Ser Glu Lys Asp Glu Lys Asp Glu
        675                 680                 685             
Asp His Glu Arg Glu Arg Phe Tyr Ile Tyr Arg Lys Pro Ser His Thr
    690                 695                 700                 
Ser Arg Lys Lys Ala Thr Gly Phe Ala Ala Val His Gln Leu Phe Thr
705                 710                 715                 720 
Glu Arg Trp Pro Thr Thr Pro Val Asn Arg Ser Leu Ser Gly Thr Ala
                725                 730                 735     
Thr Glu Arg Asn Ile Asp Phe Glu Leu Asp Ile Arg Val Glu Ile Asp
            740                 745                 750         
Ser Gly Lys Cys Val Leu His Pro Thr Thr Leu Leu Gln Glu His Asp
        755                 760                 765             
Asp Ile Ser Leu Arg Arg Ser Tyr Asp Arg Ser Ser Arg Ser Leu Asp
    770                 775                 780                 
Gln Asp Ser Pro Ser Lys Lys Lys Lys Phe Gln Thr Asn Tyr Ala Ser
785                 790                 795                 800 
Thr Thr His Leu Met Thr Gly Lys Lys Val Pro Ser Ser Leu Gln Thr
                805                 810                 815     
Lys Pro Ser Asp Leu Glu Thr Thr Val Phe Tyr Ile Pro Gly Val Asp
            820                 825                 830         
Val Lys Leu His Tyr Asn Ser Lys Thr Leu Lys Thr Glu Ser Pro Asn
        835                 840                 845             
Ala Ser Arg Gly Ser Ser Leu Pro Arg Thr Leu Ser Lys Glu Ser Lys
    850                 855                 860                 
Leu Tyr Gly Met Lys Asp Ser Ala Thr Ser Pro Pro Ser Pro Pro Leu
865                 870                 875                 880 
Pro Ser Thr Val Gln Ser Lys Thr Asn Thr Leu Leu Pro Pro Gln Pro
                885                 890                 895     
Pro Pro Ile Pro Ala Ala Lys Gly Lys Gly Ser Gly Gly Val Lys Thr
            900                 905                 910         
Ala Lys Leu Tyr Ala Trp Val Ala Leu Gln Ser Leu Pro Glu Glu Met
        915                 920                 925             
Val Ile Ser Pro Cys Leu Leu Asp Phe Leu Glu Lys Ala Leu Glu Thr
    930                 935                 940                 
Ile Pro Ile Thr Pro Val Glu Arg Asn Tyr Thr Ala Val Ser Ser Gln
945                 950                 955                 960 
Asp Glu Asp Met Gly His Phe Glu Ile Pro Asp Pro Met Glu Glu Ser
                965                 970                 975     
Thr Thr Ser Leu Val Ser Ser Ser Thr Ser Ala Tyr Ser Ser Phe Pro
            980                 985                 990         
Val Asp Val Val Val Tyr Val Arg Val Gln Pro Ser Gln Ile Lys Phe
        995                 1000                1005            
Ser Cys Leu Pro Val Ser Arg Val Glu Cys Met Leu Lys Leu Pro Ser
    1010                1015                1020                
Leu Asp Leu Val Phe Ser Ser Asn Arg Gly Glu Leu Glu Thr Leu Gly
1025                1030                1035                1040
Thr Thr Tyr Pro Ala Glu Thr Leu Ser Pro Gly Gly Asn Ala Thr Gln
                1045                1050                1055    
Ser Gly Thr Lys Thr Ser Ala Ser Lys Thr Gly Ile Pro Gly Ser Ser
            1060                1065                1070        
Gly Leu Gly Ser Pro Leu Gly Arg Ser Arg His Ser Ser Ser Gln Ser
        1075                1080                1085            
Asp Leu Thr Ser Ser Ser Ser Ser Ser Ser Gly Leu Ser Phe Thr Ala
    1090                1095                1100                
Cys Met Ser Asp Phe Ser Leu Tyr Val Phe His Pro Tyr Gly Ala Gly
1105                1110                1115                1120
Lys Gln Lys Thr Ala Val Ser Gly Leu Thr Pro Gly Ser Gly Gly Leu
                1125                1130                1135    
Gly Asn Val Asp Glu Glu Pro Thr Ser Val Thr Gly Arg Lys Asp Ser
            1140                1145                1150        
Leu Ser Ile Asn Leu Glu Phe Val Lys Val Ser Leu Ser Arg Ile Arg
        1155                1160                1165            
Arg Ser Gly Gly Ala Ser Phe Phe Glu Ser Gln Ser Val Ser Lys Ser
    1170                1175                1180                
Ala Ser Lys Met Asp Thr Thr Leu Ile Asn Ile Ser Ala Val Cys Asp
1185                1190                1195                1200
Ile Gly Ser Ala Ser Phe Lys Tyr Asp Met Arg Arg Leu Ser Glu Ile
                1205                1210                1215    
Leu Ala Phe Pro Arg Ala Trp Tyr Arg Arg Ser Ile Ala Arg Arg Leu
            1220                1225                1230        
Phe Leu Gly Asp Gln Thr Ile Asn Leu Pro Thr Ser Gly Pro Gly Thr
        1235                1240                1245            
Pro Asp Ser Ile Glu Gly Val Ser Gln His Leu Ser Pro Glu Ser Ser
    1250                1255                1260                
Arg Lys Ala Tyr Cys Lys Thr Trp Glu Gln Pro Ser Gln Ser Ala Ser
1265                1270                1275                1280
Phe Thr His Met Pro Gln Ser Pro Asn Val Phe Asn Glu His Met Thr
                1285                1290                1295    
Asn Ser Thr Met Ser Pro Gly Thr Val Gly Gln Ser Leu Lys Ser Pro
            1300                1305                1310        
Ala Ser Ile Arg Ser Arg Ser Val Ser Asp Ser Ser Val Pro Arg Arg
        1315                1320                1325            
Asp Ser Leu Ser Lys Thr Ser Thr Pro Phe Asn Lys Ser Asn Lys Ala
    1330                1335                1340                
Ala Ser Gln Gln Gly Thr Pro Trp Glu Thr Leu Val Val Phe Ala Ile
1345                1350                1355                1360
Asn Leu Lys Gln Leu Asn Val Gln Met Asn Met Ser Asn Val Met Gly
                1365                1370                1375    
Asn Thr Thr Trp Thr Thr Ser Gly Leu Lys Ser Gln Gly Arg Leu Ser
            1380                1385                1390        
Val Gly Ser Asn Arg Asp Arg Glu Ile Ser Met Ser Val Gly Leu Gly
        1395                1400                1405            
Arg Ser Gln Leu Asp Ser Lys Gly Gly Val Val Gly Gly Thr Ile Asp
    1410                1415                1420                
Val Asn Ala Leu Glu Met Val Ala His Ile Ser Glu His Pro Asn Gln
1425                1430                1435                1440
Gln Pro Ser His Lys Ile Gln Ile Thr Met Gly Ser Thr Glu Ala Arg
                1445                1450                1455    
Val Asp Tyr Met Gly Ser Ser Ile Leu Met Gly Ile Phe Ser Asn Ala
            1460                1465                1470        
Asp Leu Lys Leu Gln Asp Glu Trp Lys Val Asn Leu Tyr Asn Thr Leu
        1475                1480                1485            
Asp Ser Ser Ile Thr Asp Lys Ser Glu Ile Phe Val His Gly Asp Leu
    1490                1495                1500                
Lys Trp Asp Ile Phe Gln Val Met Ile Ser Arg Ser Thr Thr Pro Asp
1505                1510                1515                1520
Leu Ile Lys Ile Gly Met Lys Leu Gln Glu Phe Phe Thr Gln Gln Phe
                1525                1530                1535    
Asp Thr Ser Lys Arg Ala Leu Ser Thr Trp Gly Pro Val Pro Tyr Leu
            1540                1545                1550        
Pro Pro Lys Thr Met Thr Ser Asn Leu Glu Lys Ser Ser Gln Glu Gln
        1555                1560                1565            
Leu Leu Asp Ala Ala His His Arg His Trp Pro Gly Val Leu Lys Val
    1570                1575                1580                
Val Ser Gly Cys His Ile Ser Leu Phe Gln Ile Pro Leu Pro Glu Asp
1585                1590                1595                1600
Gly Met Gln Phe Gly Gly Ser Met Ser Leu His Gly Asn His Met Thr
                1605                1610                1615    
Leu Ala Cys Phe His Gly Pro Asn Phe Arg Ser Lys Ser Trp Ala Leu
            1620                1625                1630        
Phe His Leu Glu Glu Pro Asn Ile Ala Phe Trp Thr Glu Ala Gln Lys
        1635                1640                1645            
Ile Trp Glu Asp Gly Ser Ser Asp His Ser Thr Tyr Ile Val Gln Thr
    1650                1655                1660                
Leu Asp Phe His Leu Gly His Asn Thr Met Val Thr Lys Pro Cys Gly
1665                1670                1675                1680
Ala Leu Glu Ser Pro Met Ala Thr Ile Thr Lys Ile Thr Arg Arg Arg
                1685                1690                1695    
His Glu Asn Pro Pro His Gly Val Ala Ser Val Lys Glu Trp Phe Asn
            1700                1705                1710        
Tyr Val Thr Ala Thr Arg Asn Glu Glu Leu Asn Leu Leu Arg Asn Val
        1715                1720                1725            
Asp Ala Asn Asn Thr Glu Asn Ser Thr Thr Val Lys Asn Ser Ser Leu
    1730                1735                1740                
Leu Ser Gly Phe Arg Gly Gly Ser Ser Tyr Asn His Glu Thr Glu Thr
1745                1750                1755                1760
Ile Phe Ala Leu Pro Arg Met Gln Leu Asp Phe Lys Ser Ile His Val
                1765                1770                1775    
Gln Glu Pro Gln Glu Pro Ser Leu Gln Asp Ala Ser Leu Lys Pro Lys
            1780                1785                1790        
Val Glu Cys Ser Val Val Thr Glu Phe Thr Asp His Ile Cys Val Thr
        1795                1800                1805            
Met Asp Ala Glu Leu Ile Met Phe Leu His Asp Leu Val Ser Ala Tyr
    1810                1815                1820                
Leu Lys Glu Lys Glu Lys Ala Ile Phe Pro Pro Arg Ile Leu Ser Thr
1825                1830                1835                1840
Arg Pro Gly Gln Lys Ser Pro Ile Ile Ile His Asp Asp Asn Ser Ser
                1845                1850                1855    
Asp Lys Asp Arg Glu Asp Ser Ile Thr Tyr Thr Thr Val Asp Trp Arg
            1860                1865                1870        
Asp Phe Met Cys Asn Thr Trp His Leu Glu Pro Thr Leu Arg Leu Ile
        1875                1880                1885            
Ser Trp Thr Gly Arg Lys Ile Asp Pro Val Gly Val Asp Tyr Ile Leu
    1890                1895                1900                
Gln Lys Leu Gly Phe His His Ala Arg Thr Thr Ile Pro Lys Trp Leu
1905                1910                1915                1920
Gln Arg Gly Val Met Asp Pro Leu Asp Lys Val Leu Ser Val Leu Ile
                1925                1930                1935    
Lys Lys Leu Gly Thr Ala Leu Gln Asp Glu Lys Glu Lys Lys Gly Lys
            1940                1945                1950        
Asp Lys Glu Glu His
        1955        


<210> 698
<211> 478
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 231
<223> Xaa = Any Amino Acid

<400> 698
Met Phe Lys Phe His Gln Met Lys His Ile Phe Glu Ile Leu Asp Lys
 1               5                  10                  15      
Met Arg Cys Leu Arg Lys Arg Ser Thr Val Ser Phe Leu Gly Val Leu
            20                  25                  30          
Val Ile Phe Leu Leu Phe Met Asn Leu Tyr Ile Glu Asp Ser Tyr Val
        35                  40                  45              
Leu Glu Gly Asp Lys Gln Leu Ile Arg Glu Thr Ser Thr His Gln Leu
    50                  55                  60                  
Asn Ser Glu Arg Tyr Val His Thr Phe Lys Asp Leu Ser Asn Phe Ser
65                  70                  75                  80  
Gly Ala Ile Asn Val Thr Tyr Arg Tyr Leu Ala Ala Thr Pro Leu Gln
                85                  90                  95      
Arg Lys Arg Tyr Leu Thr Ile Gly Leu Ser Ser Val Lys Arg Lys Lys
            100                 105                 110         
Gly Asn Tyr Leu Leu Glu Thr Ile Lys Ser Ile Phe Glu Gln Ser Ser
        115                 120                 125             
Tyr Glu Glu Leu Lys Glu Ile Ser Val Val Val His Leu Ala Asp Phe
    130                 135                 140                 
Asn Ser Ser Trp Arg Asp Ala Met Val Gln Asp Ile Thr Gln Lys Phe
145                 150                 155                 160 
Ala His His Ile Ile Ala Gly Arg Leu Met Val Ile His Ala Pro Glu
                165                 170                 175     
Glu Tyr Tyr Pro Ile Leu Asp Gly Leu Lys Arg Asn Tyr Asn Asp Pro
            180                 185                 190         
Glu Asp Arg Val Lys Phe Arg Ser Lys Gln Asn Val Asp Tyr Ala Phe
        195                 200                 205             
Leu Leu Asn Phe Cys Ala Asn Thr Ser Asp Tyr Tyr Val Met Leu Glu
    210                 215                 220                 
Asp Asp Val Arg Cys Ser Xaa Asn Phe Leu Thr Ala Ile Lys Lys Val
225                 230                 235                 240 
Ile Ala Ser Leu Glu Gly Thr Tyr Trp Val Thr Leu Glu Phe Ser Lys
                245                 250                 255     
Leu Gly Tyr Ile Gly Lys Leu Tyr His Ser His Asp Leu Pro Arg Leu
            260                 265                 270         
Ala His Phe Leu Leu Met Phe Tyr Gln Glu Met Pro Cys Asp Trp Leu
        275                 280                 285             
Leu Thr His Phe Arg Gly Leu Leu Ala Gln Lys Asn Val Ile Arg Phe
    290                 295                 300                 
Lys Pro Ser Leu Phe Gln His Met Gly Tyr Tyr Ser Ser Tyr Lys Gly
305                 310                 315                 320 
Thr Glu Asn Lys Leu Lys Asp Asp Asp Phe Glu Glu Glu Ser Phe Asp
                325                 330                 335     
Ile Pro Asp Asn Pro Pro Ala Ser Leu Tyr Thr Asn Met Asn Val Phe
            340                 345                 350         
Glu Asn Tyr Glu Ala Ser Lys Ala Tyr Ser Ser Val Asp Glu Tyr Phe
        355                 360                 365             
Trp Gly Lys Pro Pro Ser Thr Gly Asp Val Phe Val Ile Val Phe Glu
    370                 375                 380                 
Asn Pro Ile Ile Ile Lys Lys Ile Lys Val Asn Thr Gly Thr Glu Asp
385                 390                 395                 400 
Arg Gln Asn Asp Ile Leu His His Gly Ala Leu Asp Val Gly Glu Asn
                405                 410                 415     
Val Met Pro Ser Lys Gln Arg Arg Gln Cys Ser Thr Tyr Leu Arg Leu
            420                 425                 430         
Gly Glu Phe Lys Asn Gly Asn Phe Glu Met Ser Gly Val Asn Gln Lys
        435                 440                 445             
Ile Pro Phe Asp Ile His Cys Met Arg Ile Tyr Val Thr Lys Thr Gln
    450                 455                 460                 
Lys Glu Trp Leu Ile Ile Arg Ser Ile Ser Ile Trp Thr Ser
465                 470                 475             


<210> 699
<211> 851
<212> PRT
<213> Homo sapiens

<400> 699
Met Ala Ser Leu Gly Ala Asn Pro Arg Arg Thr Pro Gln Gly Pro Arg
 1               5                  10                  15      
Pro Gly Ala Ala Ser Ser Gly Phe Pro Ser Pro Ala Pro Val Pro Gly
            20                  25                  30          
Pro Arg Glu Ala Glu Glu Glu Glu Val Glu Glu Glu Glu Glu Leu Ala
        35                  40                  45              
Glu Ile His Leu Cys Val Leu Trp Asn Ser Gly Tyr Leu Gly Ile Ala
    50                  55                  60                  
Tyr Tyr Asp Thr Ser Asp Ser Thr Ile His Phe Met Pro Asp Ala Pro
65                  70                  75                  80  
Asp His Glu Ser Leu Lys Leu Leu Gln Arg Val Leu Asp Glu Ile Asn
                85                  90                  95      
Pro Gln Ser Val Val Thr Ser Ala Lys Gln Asp Glu Asn Met Thr Arg
            100                 105                 110         
Phe Leu Gly Lys Leu Ala Ser Gln Glu His Arg Glu Pro Lys Arg Pro
        115                 120                 125             
Glu Ile Ile Phe Leu Pro Ser Val Asp Phe Gly Leu Glu Ile Ser Lys
    130                 135                 140                 
Gln Arg Leu Leu Ser Gly Asn Tyr Ser Phe Ile Pro Asp Ala Met Thr
145                 150                 155                 160 
Ala Thr Glu Lys Ile Leu Phe Leu Ser Ser Ile Ile Pro Phe Asp Cys
                165                 170                 175     
Leu Leu Thr Pro Pro Gly Asp Leu Arg Phe Thr Pro Ile Pro Leu Leu
            180                 185                 190         
Ile Pro Ser Gln Val Arg Ala Leu Gly Gly Leu Leu Lys Phe Leu Gly
        195                 200                 205             
Arg Arg Arg Ile Gly Val Glu Leu Glu Asp Tyr Asn Val Ser Val Pro
    210                 215                 220                 
Ile Leu Gly Phe Lys Lys Phe Met Leu Thr His Leu Val Asn Ile Asp
225                 230                 235                 240 
Gln Asp Thr Tyr Ser Val Leu Gln Ile Phe Lys Ser Glu Ser His Pro
                245                 250                 255     
Ser Val Tyr Lys Val Ala Ser Gly Leu Lys Glu Gly Leu Ser Leu Phe
            260                 265                 270         
Gly Ile Leu Asn Arg Cys His Cys Lys Trp Gly Glu Lys Leu Leu Arg
        275                 280                 285             
Leu Trp Phe Thr Arg Pro Thr His Asp Leu Gly Glu Leu Ser Ser Arg
    290                 295                 300                 
Leu Asp Val Ile Gln Phe Phe Leu Leu Pro Gln Asn Leu Asp Met Ala
305                 310                 315                 320 
Gln Met Leu His Arg Leu Leu Gly His Ile Lys Asn Val Pro Leu Ile
                325                 330                 335     
Leu Lys Arg Met Lys Leu Ser His Thr Lys Val Ser Asp Trp Gln Val
            340                 345                 350         
Leu Tyr Lys Thr Val Tyr Ser Ala Leu Gly Leu Arg Asp Ala Cys Arg
        355                 360                 365             
Ser Leu Pro Gln Ser Ile Gln Leu Phe Arg Asp Ile Ala Gln Glu Phe
    370                 375                 380                 
Ser Asp Asp Leu His His Ile Ala Ser Leu Ile Gly Lys Val Val Asp
385                 390                 395                 400 
Phe Glu Gly Ser Leu Ala Glu Asn Arg Phe Thr Val Leu Pro Asn Ile
                405                 410                 415     
Asp Pro Glu Ile Asp Glu Lys Lys Arg Arg Leu Met Gly Leu Pro Ser
            420                 425                 430         
Phe Leu Thr Glu Val Ala Arg Lys Glu Leu Glu Asn Leu Asp Ser Arg
        435                 440                 445             
Ile Pro Ser Cys Ser Val Ile Tyr Ile Pro Leu Ile Gly Phe Leu Leu
    450                 455                 460                 
Ser Ile Pro Arg Leu Pro Ser Met Val Glu Ala Ser Asp Phe Glu Ile
465                 470                 475                 480 
Asn Gly Leu Asp Phe Met Phe Leu Ser Glu Glu Lys Leu His Tyr Arg
                485                 490                 495     
Ser Ala Arg Thr Lys Glu Leu Asp Ala Leu Leu Gly Asp Leu His Cys
            500                 505                 510         
Glu Ile Arg Asp Gln Glu Thr Leu Leu Met Tyr Gln Leu Gln Cys Gln
        515                 520                 525             
Val Leu Ala Arg Ala Ala Val Leu Thr Arg Val Leu Asp Leu Ala Ser
    530                 535                 540                 
Arg Leu Asp Val Leu Leu Ala Leu Ala Ser Ala Ala Arg Asp Tyr Gly
545                 550                 555                 560 
Tyr Ser Arg Pro Arg Tyr Ser Pro Gln Val Leu Gly Val Arg Ile Gln
                565                 570                 575     
Asn Gly Arg His Pro Leu Met Glu Leu Cys Ala Arg Thr Phe Val Pro
            580                 585                 590         
Asn Ser Thr Glu Cys Gly Gly Asp Lys Gly Arg Val Lys Val Ile Thr
        595                 600                 605             
Gly Pro Asn Ser Ser Gly Lys Ser Ile Tyr Leu Lys Gln Val Gly Leu
    610                 615                 620                 
Ile Thr Phe Met Ala Leu Val Gly Ser Phe Val Pro Ala Glu Glu Ala
625                 630                 635                 640 
Glu Ile Gly Ala Val Asp Ala Ile Phe Thr Arg Ile His Ser Cys Glu
                645                 650                 655     
Ser Ile Ser Leu Gly Leu Ser Thr Phe Met Ile Asp Leu Asn Gln Val
            660                 665                 670         
Ala Lys Ala Val Asn Asn Ala Thr Ala Gln Ser Leu Val Leu Ile Asp
        675                 680                 685             
Glu Phe Gly Lys Gly Thr Asn Thr Val Asp Gly Leu Ala Leu Leu Ala
    690                 695                 700                 
Ala Val Leu Arg His Trp Leu Ala Arg Gly Pro Thr Cys Pro Thr Val
705                 710                 715                 720 
Phe Val Ala Thr Asn Phe Leu Ser Leu Val Gln Leu Gln Leu Leu Pro
                725                 730                 735     
Gln Gly Pro Leu Val Gln Tyr Leu Thr Met Glu Thr Cys Glu Asp Gly
            740                 745                 750         
Asn Asp Leu Val Phe Phe Tyr Gln Val Cys Glu Gly Val Ala Lys Ala
        755                 760                 765             
Ser His Ala Ser His Thr Ala Ala Gln Ala Gly Leu Pro Asp Lys Leu
    770                 775                 780                 
Val Ala Arg Gly Lys Glu Val Ser Asp Leu Ile Arg Ser Gly Lys Pro
785                 790                 795                 800 
Ile Lys Pro Val Lys Asp Leu Leu Lys Lys Asn Gln Met Glu Asn Cys
                805                 810                 815     
Gln Thr Leu Val Asp Lys Phe Met Lys Leu Asp Leu Glu Asp Pro Asn
            820                 825                 830         
Leu Asp Leu Asn Val Phe Met Ser Gln Glu Val Leu Pro Ala Ala Thr
        835                 840                 845             
Ser Ile Leu
    850     


<210> 700
<211> 415
<212> PRT
<213> Homo sapiens

<400> 700
Leu Tyr Asn Asp Asp Arg Asn Leu Leu Arg Ile Arg Glu Lys Glu Arg
 1               5                  10                  15      
Arg Asn Gln Glu Ala His Gln Glu Lys Glu Ala Phe Pro Glu Lys Ile
            20                  25                  30          
Pro Leu Phe Gly Glu Pro Tyr Lys Thr Ala Lys Gly Asp Glu Leu Ser
        35                  40                  45              
Ser Arg Ile Gln Asn Met Leu Gly Asn Tyr Glu Glu Val Lys Glu Phe
    50                  55                  60                  
Leu Ser Thr Lys Ser His Thr His Arg Leu Asp Ala Ser Glu Asn Arg
65                  70                  75                  80  
Leu Gly Lys Pro Lys Tyr Pro Leu Ile Pro Asp Lys Gly Ser Ser Ile
                85                  90                  95      
Pro Ser Ser Ser Phe His Thr Ser Val His His Gln Ser Ile His Thr
            100                 105                 110         
Pro Ala Ser Gly Pro Leu Ser Val Gly Asn Ile Ser His Asn Pro Lys
        115                 120                 125             
Met Ala Gln Pro Arg Thr Glu Pro Met Pro Ser Leu His Ala Lys Ser
    130                 135                 140                 
Cys Gly Pro Pro Asp Ser Gln His Leu Thr Gln Asp Arg Leu Gly Gln
145                 150                 155                 160 
Glu Gly Phe Gly Ser Ser His His Lys Lys Gly Asp Arg Arg Ala Asp
                165                 170                 175     
Gly Asp His Cys Ala Ser Val Thr Asp Ser Ala Pro Glu Arg Glu Leu
            180                 185                 190         
Ser Pro Leu Ile Ser Leu Pro Ser Pro Val Pro Pro Leu Ser Pro Ile
        195                 200                 205             
His Ser Asn Gln Gln Thr Leu Pro Arg Thr Gln Gly Ser Ser Lys Val
    210                 215                 220                 
His Gly Ser Ser Asn Asn Ser Lys Gly Tyr Cys Pro Ala Lys Ser Pro
225                 230                 235                 240 
Lys Asp Leu Ala Val Lys Val His Asp Lys Glu Thr Pro Gln Asp Ser
                245                 250                 255     
Leu Val Ala Pro Ala Gln Pro Pro Ser Gln Thr Phe Pro Pro Pro Ser
            260                 265                 270         
Leu Pro Ser Lys Ser Val Ala Met Gln Gln Lys Pro Thr Ala Tyr Val
        275                 280                 285             
Arg Pro Met Asp Gly Gln Asp Gln Ala Pro Ser Glu Ser Pro Glu Leu
    290                 295                 300                 
Lys Pro Leu Pro Glu Asp Tyr Arg Gln Gln Thr Phe Glu Lys Thr Asp
305                 310                 315                 320 
Leu Lys Val Pro Ala Lys Ala Lys Leu Thr Lys Leu Lys Met Pro Ser
                325                 330                 335     
Gln Ser Val Glu Gln Thr Tyr Ser Asn Glu Val His Cys Val Glu Glu
            340                 345                 350         
Ile Leu Lys Glu Met Thr His Ser Trp Pro Pro Pro Leu Thr Ala Ile
        355                 360                 365             
His Thr Pro Ser Thr Ala Glu Pro Ser Lys Phe Pro Phe Pro Thr Lys
    370                 375                 380                 
Asp Ser Gln His Val Ser Ser Val Thr Gln Asn Gln Lys Gln Tyr Asp
385                 390                 395                 400 
Thr Ser Ser Lys Thr His Ser Asn Ser Gln Gln Gly Thr Ser Ser
                405                 410                 415 


<210> 701
<211> 142
<212> PRT
<213> Homo sapiens

<400> 701
Met Ser Tyr Met Leu Pro His Leu His Asn Gly Trp Gln Val Asp Gln
 1               5                  10                  15      
Ala Ile Leu Ser Glu Glu Asp Arg Val Val Val Ile Arg Phe Gly His
            20                  25                  30          
Asp Trp Asp Pro Thr Cys Met Lys Met Asp Glu Val Leu Tyr Ser Ile
        35                  40                  45              
Ala Glu Lys Val Lys Asn Phe Ala Val Ile Tyr Leu Val Asp Ile Thr
    50                  55                  60                  
Glu Val Pro Asp Phe Asn Lys Met Tyr Glu Leu Tyr Asp Pro Cys Thr
65                  70                  75                  80  
Val Met Phe Phe Phe Arg Asn Lys His Ile Met Ile Asp Leu Gly Thr
                85                  90                  95      
Gly Asn Asn Asn Lys Ile Asn Trp Ala Met Glu Asp Lys Gln Glu Met
            100                 105                 110         
Val Asp Ile Ile Glu Thr Val Tyr Arg Gly Ala Arg Lys Gly Arg Gly
        115                 120                 125             
Leu Val Val Ser Pro Lys Asp Tyr Ser Thr Lys Tyr Arg Tyr
    130                 135                 140         


<210> 702
<211> 195
<212> PRT
<213> Homo sapiens

<400> 702
Met Ala Ala Glu Asp Val Val Ala Thr Gly Ala Asp Pro Ser Asp Leu
 1               5                  10                  15      
Glu Ser Gly Gly Leu Leu His Glu Ile Phe Thr Ser Pro Leu Asn Leu
            20                  25                  30          
Leu Leu Leu Gly Leu Cys Ile Phe Leu Leu Tyr Lys Ile Val Arg Gly
        35                  40                  45              
Asp Gln Pro Ala Ala Ser Gly Asp Ser Asp Asp Asp Glu Pro Pro Pro
    50                  55                  60                  
Leu Pro Arg Leu Lys Arg Arg Asp Phe Thr Pro Ala Glu Leu Arg Arg
65                  70                  75                  80  
Phe Asp Gly Val Gln Asp Pro Arg Ile Leu Met Ala Ile Asn Gly Lys
                85                  90                  95      
Val Phe Asp Val Thr Lys Gly Arg Lys Phe Tyr Gly Pro Glu Gly Pro
            100                 105                 110         
Tyr Gly Val Phe Ala Gly Arg Asp Ala Ser Arg Gly Leu Ala Thr Phe
        115                 120                 125             
Cys Leu Asp Lys Glu Ala Leu Lys Asp Glu Tyr Asp Asp Leu Ser Asp
    130                 135                 140                 
Leu Thr Ala Ala Gln Gln Glu Thr Leu Ser Asp Trp Glu Ser Gln Phe
145                 150                 155                 160 
Thr Phe Lys Tyr His His Val Gly Lys Leu Leu Lys Glu Gly Glu Glu
                165                 170                 175     
Pro Thr Val Tyr Ser Asp Glu Glu Glu Pro Lys Asp Glu Ser Ala Arg
            180                 185                 190         
Lys Asn Asp
        195 


<210> 703
<211> 646
<212> PRT
<213> Homo sapiens

<400> 703
Met Ser Lys Gly Pro Ala Val Gly Ile Asp Leu Gly Thr Thr Tyr Ser
 1               5                  10                  15      
Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp
            20                  25                  30          
Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu
        35                  40                  45              
Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Met Asn Pro Thr
    50                  55                  60                  
Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Arg Phe Asp Asp
65                  70                  75                  80  
Ala Val Val Gln Ser Asp Met Lys His Trp Pro Phe Met Val Val Asn
                85                  90                  95      
Asp Ala Gly Arg Pro Lys Val Gln Val Glu Tyr Lys Gly Glu Thr Lys
            100                 105                 110         
Ser Phe Tyr Pro Glu Glu Val Ser Ser Met Val Leu Thr Lys Met Lys
        115                 120                 125             
Glu Ile Ala Glu Ala Tyr Leu Gly Lys Thr Val Thr Asn Ala Val Val
    130                 135                 140                 
Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp
145                 150                 155                 160 
Ala Gly Thr Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro
                165                 170                 175     
Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Lys Lys Val Gly Ala Glu
            180                 185                 190         
Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser
        195                 200                 205             
Ile Leu Thr Ile Glu Asp Gly Ile Phe Glu Val Lys Ser Thr Ala Gly
    210                 215                 220                 
Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Met Val Asn His
225                 230                 235                 240 
Phe Ile Ala Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Glu Asn
                245                 250                 255     
Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg
            260                 265                 270         
Thr Leu Ser Ser Ser Thr Gln Ala Ser Ile Glu Ile Asp Ser Leu Tyr
        275                 280                 285             
Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu
    290                 295                 300                 
Leu Asn Ala Asp Leu Phe Arg Gly Thr Leu Asp Pro Val Glu Lys Ala
305                 310                 315                 320 
Leu Arg Asp Ala Lys Leu Asp Lys Ser Gln Ile His Asp Ile Val Leu
                325                 330                 335     
Val Gly Gly Ser Thr Arg Ile Pro Lys Ile Gln Lys Leu Leu Gln Asp
            340                 345                 350         
Phe Phe Asn Gly Lys Glu Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala
        355                 360                 365             
Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Ser Gly Asp Lys
    370                 375                 380                 
Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Thr Pro Leu Ser
385                 390                 395                 400 
Leu Gly Ile Glu Thr Ala Gly Gly Val Met Thr Val Leu Ile Lys Arg
                405                 410                 415     
Asn Thr Thr Ile Pro Thr Lys Gln Thr Gln Thr Phe Thr Thr Tyr Ser
            420                 425                 430         
Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala
        435                 440                 445             
Met Thr Lys Asp Asn Asn Leu Leu Gly Lys Phe Glu Leu Thr Gly Ile
    450                 455                 460                 
Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile
465                 470                 475                 480 
Asp Ala Asn Gly Ile Leu Asn Val Ser Ala Val Asp Lys Ser Thr Gly
                485                 490                 495     
Lys Glu Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys
            500                 505                 510         
Glu Asp Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu
        515                 520                 525             
Asp Glu Lys Gln Arg Asp Lys Val Ser Ser Lys Asn Ser Leu Glu Ser
    530                 535                 540                 
Tyr Ala Phe Asn Met Lys Ala Thr Val Glu Asp Glu Lys Leu Gln Gly
545                 550                 555                 560 
Lys Ile Asn Asp Glu Asp Lys Gln Lys Ile Leu Asp Lys Cys Asn Glu
                565                 570                 575     
Ile Ile Asn Trp Leu Asp Lys Asn Gln Thr Ala Glu Lys Glu Glu Phe
            580                 585                 590         
Glu His Gln Gln Lys Glu Leu Glu Lys Val Cys Asn Pro Ile Ile Thr
        595                 600                 605             
Lys Leu Tyr Gln Ser Ala Gly Gly Met Pro Gly Gly Met Pro Gly Gly
    610                 615                 620                 
Phe Pro Gly Gly Gly Ala Pro Pro Ser Gly Gly Ala Ser Ser Gly Pro
625                 630                 635                 640 
Thr Ile Glu Glu Val Asp
                645     


<210> 704
<211> 1575
<212> PRT
<213> Homo sapiens

<400> 704
Met Pro His Glu Glu Leu Pro Ser Leu Gln Arg Pro Arg Tyr Gly Ser
 1               5                  10                  15      
Ile Val Asp Asp Glu Arg Leu Ser Ala Glu Glu Met Asp Glu Arg Arg
            20                  25                  30          
Arg Gln Asn Ile Ala Tyr Glu Tyr Leu Cys His Leu Glu Glu Ala Lys
        35                  40                  45              
Arg Trp Met Glu Val Cys Leu Val Glu Glu Leu Pro Pro Thr Thr Glu
    50                  55                  60                  
Leu Glu Glu Gly Leu Arg Asn Gly Val Tyr Leu Ala Lys Leu Ala Lys
65                  70                  75                  80  
Phe Phe Ala Pro Lys Met Val Ser Glu Lys Lys Ile Tyr Asp Val Glu
                85                  90                  95      
Gln Thr Arg Tyr Lys Lys Ser Gly Leu His Phe Arg His Thr Asp Asn
            100                 105                 110         
Thr Val Gln Trp Leu Arg Ala Met Glu Ser Ile Gly Leu Pro Lys Ile
        115                 120                 125             
Phe Tyr Pro Glu Thr Thr Asp Val Tyr Asp Arg Lys Asn Ile Pro Arg
    130                 135                 140                 
Met Ile Tyr Cys Ile His Ala Leu Ser Leu Tyr Leu Phe Lys Leu Gly
145                 150                 155                 160 
Ile Ala Pro Gln Ile Gln Asp Leu Leu Gly Lys Val Asp Phe Thr Glu
                165                 170                 175     
Glu Glu Ile Ser Asn Met Arg Lys Glu Leu Glu Lys Tyr Gly Ile Gln
            180                 185                 190         
Met Pro Ser Phe Ser Lys Ile Gly Gly Ile Leu Ala Asn Glu Leu Ser
        195                 200                 205             
Val Asp Glu Ala Ala Leu His Ala Ala Val Ile Ala Ile Asn Glu Ala
    210                 215                 220                 
Val Glu Lys Gly Ile Ala Glu Gln Thr Val Val Thr Leu Arg Asn Pro
225                 230                 235                 240 
Asn Ala Val Leu Thr Leu Val Asp Asp Asn Leu Ala Pro Glu Tyr Gln
                245                 250                 255     
Lys Glu Leu Trp Asp Ala Lys Lys Lys Lys Glu Glu Asn Ala Arg Leu
            260                 265                 270         
Lys Asn Ser Cys Ile Ser Glu Glu Glu Arg Asp Ala Tyr Glu Glu Leu
        275                 280                 285             
Leu Thr Gln Ala Glu Ile Gln Gly Asn Ile Asn Lys Val Asn Arg Gln
    290                 295                 300                 
Ala Ala Val Asp His Ile Asn Ala Val Ile Pro Glu Gly Asp Pro Glu
305                 310                 315                 320 
Asn Thr Leu Leu Ala Leu Lys Lys Pro Glu Ala Gln Leu Pro Ala Val
                325                 330                 335     
Tyr Pro Phe Ala Ala Ala Met Tyr Gln Asn Glu Leu Phe Asn Leu Gln
            340                 345                 350         
Lys Gln Asn Thr Met Asn Tyr Leu Ala His Glu Glu Leu Leu Ile Ala
        355                 360                 365             
Val Glu Met Leu Ser Ala Val Ala Leu Leu Asn Gln Ala Leu Glu Ser
    370                 375                 380                 
Asn Asp Leu Val Ser Val Gln Asn Gln Leu Arg Ser Pro Ala Ile Gly
385                 390                 395                 400 
Leu Asn Asn Leu Asp Lys Ala Tyr Val Glu Arg Tyr Ala Asn Thr Leu
                405                 410                 415     
Leu Ser Val Lys Leu Glu Val Leu Ser Gln Gly Gln Asp Asn Leu Ser
            420                 425                 430         
Trp Asn Glu Ile Gln Asn Cys Ile Asp Met Val Asn Ala Gln Ile Gln
        435                 440                 445             
Glu Glu Asn Asp Arg Val Val Ala Val Gly Tyr Ile Asn Glu Ala Ile
    450                 455                 460                 
Asp Glu Gly Asn Pro Leu Arg Thr Leu Glu Thr Leu Leu Leu Pro Thr
465                 470                 475                 480 
Ala Asn Ile Ser Asp Val Asp Pro Ala His Ala Gln His Tyr Gln Asp
                485                 490                 495     
Val Leu Tyr His Ala Lys Ser Gln Lys Leu Gly Asp Ser Glu Ser Val
            500                 505                 510         
Ser Lys Val Leu Trp Leu Asp Glu Ile Gln Gln Ala Val Asp Glu Ala
        515                 520                 525             
Asn Val Asp Glu Asp Arg Ala Lys Gln Trp Val Thr Leu Val Val Asp
    530                 535                 540                 
Val Asn Gln Cys Leu Glu Gly Lys Lys Ser Ser Asp Ile Leu Ser Val
545                 550                 555                 560 
Leu Lys Ser Ser Thr Ser Asn Ala Asn Asp Ile Ile Pro Glu Cys Ala
                565                 570                 575     
Asp Lys Tyr Tyr Asp Ala Leu Val Lys Ala Lys Glu Leu Lys Ser Glu
            580                 585                 590         
Arg Val Ser Ser Asp Gly Ser Trp Leu Lys Leu Asn Leu His Lys Lys
        595                 600                 605             
Tyr Asp Tyr Tyr Tyr Asn Thr Asp Ser Lys Glu Ser Ser Trp Val Thr
    610                 615                 620                 
Pro Glu Ser Cys Phe Tyr Lys Glu Ser Trp Leu Thr Gly Lys Glu Ile
625                 630                 635                 640 
Glu Asp Ile Ile Glu Glu Val Thr Val Gly Tyr Ile Arg Glu Asn Ile
                645                 650                 655     
Trp Ser Ala Ser Glu Glu Leu Leu Leu Arg Phe Gln Ala Thr Ser Ser
            660                 665                 670         
Gly Pro Ile Leu Arg Glu Glu Phe Glu Ala Arg Lys Ser Phe Leu His
        675                 680                 685             
Glu Gln Glu Glu Asn Val Val Lys Ile Gln Ala Phe Trp Lys Gly Tyr
    690                 695                 700                 
Lys Gln Arg Lys Glu Tyr Met His Arg Arg Gln Thr Phe Ile Asp Asn
705                 710                 715                 720 
Thr Asp Ser Val Val Lys Ile Gln Ser Trp Phe Arg Met Ala Thr Ala
                725                 730                 735     
Arg Lys Ser Tyr Leu Ser Arg Leu Gln Tyr Phe Arg Asp His Asn Asn
            740                 745                 750         
Glu Ile Val Lys Ile Gln Ser Leu Leu Arg Ala Asn Lys Ala Arg Asp
        755                 760                 765             
Asp Tyr Lys Thr Leu Val Gly Ser Glu Asn Pro Pro Leu Thr Val Ile
    770                 775                 780                 
Arg Lys Phe Val Tyr Leu Leu Asp Gln Ser Asp Leu Asp Phe Gln Glu
785                 790                 795                 800 
Glu Leu Glu Val Ala Arg Leu Arg Glu Glu Val Val Thr Lys Ile Arg
                805                 810                 815     
Ala Asn Gln Gln Leu Glu Lys Asp Leu Asn Leu Met Asp Ile Lys Ile
            820                 825                 830         
Gly Leu Leu Val Lys Asn Arg Ile Thr Leu Glu Asp Val Ile Ser His
        835                 840                 845             
Ser Lys Lys Leu Asn Lys Lys Lys Gly Gly Glu Met Glu Ile Leu Asn
    850                 855                 860                 
Asn Thr Asp Asn Gln Gly Ile Lys Ser Leu Ser Lys Glu Arg Arg Lys
865                 870                 875                 880 
Thr Leu Glu Thr Tyr Gln Gln Leu Phe Tyr Leu Leu Gln Thr Asn Pro
                885                 890                 895     
Leu Tyr Leu Ala Lys Leu Ile Phe Gln Met Pro Gln Asn Lys Ser Thr
            900                 905                 910         
Lys Phe Met Asp Thr Val Ile Phe Thr Leu Tyr Asn Tyr Ala Ser Asn
        915                 920                 925             
Gln Arg Glu Glu Tyr Leu Leu Leu Lys Leu Phe Lys Thr Ala Leu Glu
    930                 935                 940                 
Glu Glu Ile Lys Ser Lys Val Asp Gln Val Gln Asp Ile Val Thr Gly
945                 950                 955                 960 
Asn Pro Thr Val Ile Lys Met Val Val Ser Phe Asn Arg Gly Ala Arg
                965                 970                 975     
Gly Gln Asn Thr Leu Arg Gln Leu Leu Ala Pro Val Val Lys Glu Ile
            980                 985                 990         
Ile Asp Asp Lys Ser Leu Ile Ile Asn Thr Asn Pro Val Glu Val Tyr
        995                 1000                1005            
Lys Ala Trp Val Asn Gln Leu Glu Thr Gln Thr Gly Glu Ala Ser Lys
    1010                1015                1020                
Leu Pro Tyr Asp Val Thr Thr Glu Gln Ala Leu Thr Tyr Pro Glu Val
1025                1030                1035                1040
Lys Asn Lys Leu Glu Ala Ser Ile Glu Asn Leu Arg Arg Val Thr Asp
                1045                1050                1055    
Lys Val Leu Asn Ser Ile Ile Ser Ser Leu Asp Leu Leu Pro Tyr Gly
            1060                1065                1070        
Leu Arg Tyr Ile Ala Lys Val Leu Lys Asn Ser Ile His Glu Lys Phe
        1075                1080                1085            
Pro Asp Ala Thr Glu Asp Glu Leu Leu Lys Ile Val Gly Asn Leu Leu
    1090                1095                1100                
Tyr Tyr Arg Tyr Met Asn Pro Ala Ile Val Ala Pro Asp Gly Phe Asp
1105                1110                1115                1120
Ile Ile Asp Met Thr Ala Gly Gly Gln Ile Asn Ser Asp Gln Arg Arg
                1125                1130                1135    
Asn Leu Gly Ser Val Ala Lys Val Leu Gln His Ala Ala Ser Asn Lys
            1140                1145                1150        
Leu Phe Glu Gly Glu Asn Glu His Leu Ser Ser Met Asn Asn Tyr Leu
        1155                1160                1165            
Ser Glu Thr Tyr Gln Glu Phe Arg Lys Tyr Phe Lys Glu Ala Cys Asn
    1170                1175                1180                
Val Pro Glu Pro Glu Glu Lys Phe Asn Met Asp Lys Tyr Thr Asp Leu
1185                1190                1195                1200
Val Thr Val Ser Lys Pro Val Ile Tyr Ile Ser Ile Glu Glu Ile Ile
                1205                1210                1215    
Ser Thr His Ser Leu Leu Leu Glu His Gln Asp Ala Ile Ala Pro Glu
            1220                1225                1230        
Lys Asn Asp Leu Leu Ser Glu Leu Leu Gly Ser Leu Gly Glu Val Pro
        1235                1240                1245            
Thr Val Glu Ser Phe Leu Gly Glu Gly Ala Val Asp Pro Asn Asp Pro
    1250                1255                1260                
Asn Lys Ala Asn Thr Leu Ser Gln Leu Ser Lys Thr Glu Ile Ser Leu
1265                1270                1275                1280
Val Leu Thr Ser Lys Tyr Asp Ile Glu Asp Gly Glu Ala Ile Asp Ser
                1285                1290                1295    
Arg Ser Leu Met Ile Lys Thr Lys Lys Leu Ile Ile Asp Val Ile Arg
            1300                1305                1310        
Asn Gln Pro Gly Asn Thr Leu Thr Glu Ile Leu Glu Thr Pro Ala Thr
        1315                1320                1325            
Ala Gln Gln Glu Val Asp His Ala Thr Asp Met Val Ser Arg Ala Met
    1330                1335                1340                
Ile Asp Ser Arg Thr Pro Glu Glu Met Lys His Ser Gln Ser Met Ile
1345                1350                1355                1360
Glu Asp Ala Gln Leu Pro Leu Glu Gln Lys Lys Arg Lys Ile Gln Arg
                1365                1370                1375    
Asn Leu Arg Thr Leu Glu Gln Thr Gly His Val Ser Ser Glu Asn Lys
            1380                1385                1390        
Tyr Gln Asp Ile Leu Asn Glu Ile Ala Lys Asp Ile Arg Asn Gln Arg
        1395                1400                1405            
Ile Tyr Arg Lys Leu Arg Lys Ala Glu Leu Ala Lys Leu Gln Gln Thr
    1410                1415                1420                
Leu Asn Ala Leu Asn Lys Lys Ala Ala Phe Tyr Glu Glu Gln Ile Asn
1425                1430                1435                1440
Tyr Tyr Asp Thr Tyr Ile Lys Thr Cys Leu Asp Asn Leu Lys Arg Lys
                1445                1450                1455    
Asn Thr Arg Arg Ser Ile Lys Leu Asp Gly Lys Gly Glu Pro Lys Gly
            1460                1465                1470        
Ala Lys Arg Ala Lys Pro Val Lys Tyr Thr Ala Ala Lys Leu His Glu
        1475                1480                1485            
Lys Gly Val Leu Leu Asp Ile Asp Asp Leu Gln Thr Asn Gln Phe Lys
    1490                1495                1500                
Asn Val Thr Phe Asp Ile Ile Ala Thr Glu Asp Val Gly Ile Phe Asp
1505                1510                1515                1520
Val Arg Ser Lys Phe Leu Gly Val Glu Met Glu Lys Val Gln Leu Asn
                1525                1530                1535    
Ile Gln Asp Leu Leu Gln Met Gln Tyr Glu Gly Val Ala Val Met Lys
            1540                1545                1550        
Met Phe Asp Lys Val Lys Val Asn Val Asn Leu Leu Ile Tyr Leu Leu
        1555                1560                1565            
Asn Lys Lys Phe Tyr Gly Lys
    1570                1575


<210> 705
<211> 263
<212> PRT
<213> Homo sapiens

<400> 705
Met Ser Leu Val Ala Glu Ala Phe Val Ser Gln Ile Ala Ala Ala Glu
 1               5                  10                  15      
Pro Trp Pro Glu Asn Ala Thr Leu Tyr Gln Gln Leu Lys Gly Glu Gln
            20                  25                  30          
Ile Leu Leu Ser Asp Asn Ala Ala Ser Leu Ala Val Gln Ala Phe Leu
        35                  40                  45              
Gln Met Cys Asn Leu Pro Ile Lys Val Val Cys Arg Ala Asn Ala Glu
    50                  55                  60                  
Tyr Met Ser Pro Ser Gly Lys Val Pro Phe Ile His Val Gly Asn Gln
65                  70                  75                  80  
Val Val Ser Glu Leu Gly Pro Ile Val Gln Phe Val Lys Ala Lys Gly
                85                  90                  95      
His Ser Leu Ser Asp Gly Leu Glu Glu Val Gln Lys Ala Glu Met Lys
            100                 105                 110         
Ala Tyr Met Glu Leu Val Asn Asn Met Leu Leu Thr Ala Glu Leu Tyr
        115                 120                 125             
Leu Gln Trp Cys Asp Glu Ala Thr Val Gly Glu Ile Thr His Ala Arg
    130                 135                 140                 
Tyr Gly Ser Pro Tyr Pro Trp Pro Leu Asn His Ile Leu Ala Tyr Gln
145                 150                 155                 160 
Lys Gln Trp Glu Val Lys Arg Lys Met Lys Ala Ile Gly Trp Gly Lys
                165                 170                 175     
Lys Thr Leu Asp Gln Val Leu Glu Asp Val Asp Gln Cys Cys Gln Ala
            180                 185                 190         
Leu Ser Gln Arg Leu Gly Thr Gln Pro Tyr Phe Phe Asn Lys Gln Pro
        195                 200                 205             
Thr Glu Leu Asp Ala Leu Val Phe Gly His Leu Tyr Thr Ile Leu Thr
    210                 215                 220                 
Thr Gln Leu Thr Asn Asp Glu Leu Ser Glu Lys Val Lys Asn Tyr Ser
225                 230                 235                 240 
Asn Leu Leu Ala Phe Cys Arg Arg Ile Glu Gln His Tyr Phe Glu Asp
                245                 250                 255     
Arg Gly Lys Gly Arg Leu Ser
            260             


<210> 706
<211> 263
<212> PRT
<213> Homo sapiens

<400> 706
Met Ser Leu Val Ala Glu Ala Phe Val Ser Gln Ile Ala Ala Ala Glu
 1               5                  10                  15      
Pro Trp Pro Glu Asn Ala Thr Leu Tyr Gln Gln Leu Lys Gly Glu Gln
            20                  25                  30          
Ile Leu Leu Ser Asp Asn Ala Ala Ser Leu Ala Val Gln Ala Phe Leu
        35                  40                  45              
Gln Met Cys Asn Leu Pro Ile Lys Val Val Cys Arg Ala Asn Ala Glu
    50                  55                  60                  
Tyr Met Ser Pro Ser Gly Lys Val Pro Phe Ile His Val Gly Asn Gln
65                  70                  75                  80  
Val Val Ser Glu Leu Gly Pro Ile Val Gln Phe Val Lys Ala Lys Gly
                85                  90                  95      
His Ser Leu Ser Asp Gly Leu Glu Glu Val Gln Lys Ala Glu Met Lys
            100                 105                 110         
Ala Tyr Met Glu Leu Val Asn Asn Met Leu Leu Thr Ala Glu Leu Tyr
        115                 120                 125             
Leu Gln Trp Cys Asp Glu Ala Thr Val Gly Glu Ile Thr His Ala Arg
    130                 135                 140                 
Tyr Gly Ser Pro Tyr Pro Trp Pro Leu Asn His Ile Leu Ala Tyr Gln
145                 150                 155                 160 
Lys Gln Trp Glu Val Lys Arg Lys Met Lys Ala Ile Gly Trp Gly Lys
                165                 170                 175     
Lys Thr Leu Asp Gln Val Leu Glu Asp Val Asp Gln Cys Cys Gln Ala
            180                 185                 190         
Leu Ser Gln Arg Leu Gly Thr Gln Pro Tyr Phe Phe Asn Lys Gln Pro
        195                 200                 205             
Thr Glu Leu Asp Ala Leu Val Phe Gly His Leu Tyr Thr Ile Leu Thr
    210                 215                 220                 
Thr Gln Leu Thr Asn Asp Glu Leu Ser Glu Lys Val Lys Asn Tyr Ser
225                 230                 235                 240 
Asn Leu Leu Ala Phe Cys Arg Arg Ile Glu Gln His Tyr Phe Glu Asp
                245                 250                 255     
Arg Gly Lys Gly Arg Leu Ser
            260             


<210> 707
<211> 143
<212> PRT
<213> Homo sapiens

<400> 707
Met Cys Pro Arg Lys Trp Ser Cys Phe Gly Val Pro Gly Val Thr His
 1               5                  10                  15      
His Pro Leu Glu Gln Pro Glu Arg Ser Arg Ala Ser Ala Pro Met Leu
            20                  25                  30          
Leu Arg Met Ser Glu His Arg Asn Glu Ala Leu Gly Asn Tyr Leu Glu
        35                  40                  45              
Met Arg Leu Lys Ser Ser Phe Leu Arg Gly Leu Gly Ser Trp Lys Ser
    50                  55                  60                  
Asn Pro Leu Arg Leu Gly Gly Trp Thr Ile Leu Leu Thr Leu Thr Met
65                  70                  75                  80  
Gly Gln Gly Glu Pro Gly Gly Pro Arg Ile Pro Gly Phe His Thr Asn
                85                  90                  95      
Ser Ser Tyr Pro His Cys Val Thr Ala Ala Met Pro Pro Pro Gly Asp
            100                 105                 110         
Gln Asp Leu Leu Pro Val Pro Gly Glu Glu Gly Thr Pro Leu Leu Thr
        115                 120                 125             
Arg Trp Ser Leu Asp Thr Tyr Cys Pro Ile Pro Leu Trp Gln Leu
    130                 135                 140             


<210> 708
<211> 443
<212> PRT
<213> Homo sapiens

<400> 708
Met Gln Arg Arg Asp Asp Pro Ala Ala Arg Met Ser Arg Ser Ser Gly
 1               5                  10                  15      
Arg Ser Gly Ser Met Asp Pro Ser Gly Ala His Pro Ser Val Arg Gln
            20                  25                  30          
Thr Pro Ser Arg Gln Pro Pro Leu Pro His Arg Ser Arg Gly Gly Gly
        35                  40                  45              
Gly Gly Ser Arg Gly Gly Ala Arg Ala Ser Pro Ala Thr Gln Pro Pro
    50                  55                  60                  
Pro Leu Leu Pro Pro Ser Ala Thr Gly Pro Asp Ala Thr Val Gly Gly
65                  70                  75                  80  
Pro Ala Pro Thr Pro Leu Leu Pro Pro Ser Ala Thr Ala Ser Val Lys
                85                  90                  95      
Met Glu Pro Glu Asn Lys Tyr Leu Pro Glu Leu Met Ala Glu Lys Asp
            100                 105                 110         
Ser Leu Asp Pro Ser Phe Thr His Ala Met Gln Leu Leu Thr Ala Glu
        115                 120                 125             
Ile Glu Lys Ile Gln Lys Gly Asp Ser Lys Lys Asp Asp Glu Glu Asn
    130                 135                 140                 
Tyr Leu Asp Leu Phe Ser His Lys Asn Met Lys Leu Lys Glu Arg Val
145                 150                 155                 160 
Leu Ile Pro Val Lys Gln Tyr Pro Lys Phe Asn Phe Val Gly Lys Ile
                165                 170                 175     
Leu Gly Pro Gln Gly Asn Thr Ile Lys Arg Leu Gln Glu Glu Thr Gly
            180                 185                 190         
Ala Lys Ile Ser Val Leu Gly Lys Gly Ser Met Arg Asp Lys Ala Lys
        195                 200                 205             
Glu Glu Glu Leu Arg Lys Gly Gly Asp Pro Lys Tyr Ala His Leu Asn
    210                 215                 220                 
Met Asp Leu His Val Phe Ile Glu Val Phe Gly Pro Pro Cys Glu Ala
225                 230                 235                 240 
Tyr Ala Leu Met Ala His Ala Met Glu Glu Val Lys Lys Phe Leu Val
                245                 250                 255     
Pro Asp Met Met Asp Asp Ile Cys Gln Glu Gln Phe Leu Glu Leu Ser
            260                 265                 270         
Tyr Leu Asn Gly Val Pro Glu Pro Ser Arg Gly Arg Gly Val Pro Val
        275                 280                 285             
Arg Gly Arg Gly Ala Ala Pro Pro Pro Pro Pro Val Pro Arg Gly Arg
    290                 295                 300                 
Gly Val Gly Pro Pro Arg Gly Ala Leu Val Arg Gly Thr Pro Val Arg
305                 310                 315                 320 
Gly Ala Ile Thr Arg Gly Ala Thr Val Thr Arg Gly Val Pro Pro Pro
                325                 330                 335     
Pro Thr Val Arg Gly Ala Pro Ala Pro Arg Ala Arg Thr Ala Gly Ile
            340                 345                 350         
Gln Arg Ile Pro Leu Pro Pro Pro Pro Ala Pro Glu Thr Tyr Glu Glu
        355                 360                 365             
Tyr Gly Tyr Asp Asp Thr Tyr Ala Glu Gln Ser Tyr Glu Gly Tyr Glu
    370                 375                 380                 
Gly Tyr Tyr Ser Gln Ser Gln Gly Asp Ser Glu Tyr Tyr Asp Tyr Gly
385                 390                 395                 400 
His Gly Glu Val Gln Asp Ser Tyr Glu Ala Tyr Gly Gln Asp Asp Trp
                405                 410                 415     
Asn Gly Thr Arg Pro Ser Leu Lys Ala Pro Pro Ala Arg Pro Val Lys
            420                 425                 430         
Gly Ala Tyr Arg Glu His Pro Tyr Gly Arg Tyr
        435                 440             


<210> 709
<211> 1956
<212> PRT
<213> Homo sapiens

<400> 709
Met Glu Phe Pro Ile Gly Ser Leu Glu Thr Asn Asn Phe Arg Arg Phe
 1               5                  10                  15      
Thr Pro Glu Ser Leu Val Glu Ile Glu Lys Gln Ile Ala Ala Lys Gln
            20                  25                  30          
Gly Thr Lys Lys Ala Arg Glu Lys His Arg Glu Gln Lys Asp Gln Glu
        35                  40                  45              
Glu Lys Pro Arg Pro Gln Leu Asp Leu Lys Ala Cys Asn Gln Leu Pro
    50                  55                  60                  
Lys Phe Tyr Gly Glu Leu Pro Ala Glu Leu Ile Gly Glu Pro Leu Glu
65                  70                  75                  80  
Asp Leu Asp Pro Phe Tyr Ser Thr His Arg Thr Phe Met Val Leu Asn
                85                  90                  95      
Lys Gly Arg Thr Ile Ser Arg Phe Ser Ala Thr Arg Ala Leu Trp Leu
            100                 105                 110         
Phe Ser Pro Phe Asn Leu Ile Arg Arg Thr Ala Ile Lys Val Ser Val
        115                 120                 125             
His Ser Trp Phe Ser Leu Phe Ile Thr Val Thr Ile Leu Val Asn Cys
    130                 135                 140                 
Val Cys Met Thr Arg Thr Asp Leu Pro Glu Lys Ile Glu Tyr Val Phe
145                 150                 155                 160 
Thr Val Ile Tyr Thr Phe Glu Ala Leu Ile Lys Ile Leu Ala Arg Gly
                165                 170                 175     
Phe Cys Leu Asn Glu Phe Thr Tyr Leu Arg Asp Pro Trp Asn Trp Leu
            180                 185                 190         
Asp Phe Ser Val Ile Thr Leu Ala Tyr Val Gly Thr Ala Ile Asp Leu
        195                 200                 205             
Arg Gly Ile Ser Gly Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys
    210                 215                 220                 
Thr Val Ser Val Ile Pro Gly Leu Lys Val Ile Val Gly Ala Leu Ile
225                 230                 235                 240 
His Ser Val Lys Lys Leu Ala Asp Val Thr Ile Leu Thr Ile Phe Cys
                245                 250                 255     
Leu Ser Val Phe Ala Leu Val Gly Leu Gln Leu Phe Lys Gly Asn Leu
            260                 265                 270         
Lys Asn Lys Cys Val Lys Asn Asp Met Ala Val Asn Glu Thr Thr Asn
        275                 280                 285             
Tyr Ser Ser His Arg Lys Pro Asp Ile Tyr Ile Asn Lys Arg Gly Thr
    290                 295                 300                 
Ser Asp Pro Leu Leu Cys Gly Asn Gly Ser Asp Ser Gly His Cys Pro
305                 310                 315                 320 
Asp Gly Tyr Ile Cys Leu Lys Thr Ser Asp Asn Pro Asp Phe Asn Tyr
                325                 330                 335     
Thr Ser Phe Asp Ser Phe Ala Trp Ala Phe Leu Ser Leu Phe Arg Leu
            340                 345                 350         
Met Thr Gln Asp Ser Trp Glu Arg Leu Tyr Gln Gln Thr Leu Arg Thr
        355                 360                 365             
Ser Gly Lys Ile Tyr Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly
    370                 375                 380                 
Ser Phe Tyr Leu Val Asn Leu Ile Leu Ala Val Val Thr Met Ala Tyr
385                 390                 395                 400 
Glu Glu Gln Asn Gln Ala Thr Thr Asp Glu Ile Glu Ala Lys Glu Lys
                405                 410                 415     
Lys Phe Gln Glu Ala Leu Glu Met Leu Arg Lys Glu Gln Glu Val Leu
            420                 425                 430         
Ala Ala Leu Gly Ile Asp Thr Thr Ser Leu His Ser His Asn Gly Ser
        435                 440                 445             
Pro Leu Thr Ser Lys Asn Ala Ser Glu Arg Arg His Arg Ile Lys Pro
    450                 455                 460                 
Arg Val Ser Glu Gly Ser Thr Glu Asp Asn Lys Ser Pro Arg Ser Asp
465                 470                 475                 480 
Pro Tyr Asn Gln Arg Arg Met Ser Phe Leu Gly Leu Ala Ser Gly Lys
                485                 490                 495     
Arg Arg Ala Ser His Gly Ser Val Phe His Phe Arg Ser Pro Gly Arg
            500                 505                 510         
Asp Ile Ser Leu Pro Glu Gly Val Thr Asp Asp Gly Val Phe Pro Gly
        515                 520                 525             
Asp His Glu Ser His Arg Gly Ser Leu Leu Leu Gly Gly Gly Ala Gly
    530                 535                 540                 
Gln Gln Gly Pro Leu Pro Arg Ser Pro Leu Pro Gln Pro Ser Asn Pro
545                 550                 555                 560 
Asp Ser Arg His Gly Glu Asp Glu His Gln Pro Pro Pro Thr Ser Glu
                565                 570                 575     
Leu Ala Pro Gly Ala Val Asp Val Ser Ala Phe Asp Ala Gly Gln Lys
            580                 585                 590         
Lys Thr Phe Leu Ser Ala Glu Tyr Leu Asp Glu Pro Phe Arg Ala Gln
        595                 600                 605             
Arg Ala Met Ser Val Val Ser Ile Ile Thr Ser Val Leu Glu Glu Leu
    610                 615                 620                 
Glu Glu Ser Glu Gln Lys Cys Pro Pro Cys Leu Thr Ser Leu Ser Gln
625                 630                 635                 640 
Lys Tyr Leu Ile Trp Asp Cys Cys Pro Met Trp Val Lys Leu Lys Thr
                645                 650                 655     
Ile Leu Phe Gly Leu Val Thr Asp Pro Phe Ala Glu Leu Thr Ile Thr
            660                 665                 670         
Leu Cys Ile Val Val Asn Thr Ile Phe Met Ala Met Glu His His Gly
        675                 680                 685             
Met Ser Pro Thr Phe Glu Ala Met Leu Gln Ile Gly Asn Ile Val Phe
    690                 695                 700                 
Thr Ile Phe Phe Thr Ala Glu Met Val Phe Lys Ile Ile Ala Phe Asp
705                 710                 715                 720 
Pro Tyr Tyr Tyr Phe Gln Lys Lys Trp Asn Ile Phe Asp Cys Ile Ile
                725                 730                 735     
Val Thr Val Ser Leu Leu Glu Leu Gly Val Ala Lys Lys Gly Ser Leu
            740                 745                 750         
Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys
        755                 760                 765             
Ser Trp Pro Thr Leu Asn Thr Leu Ile Lys Ile Ile Gly Asn Ser Val
    770                 775                 780                 
Gly Ala Leu Gly Asn Leu Thr Ile Ile Leu Ala Ile Ile Val Phe Val
785                 790                 795                 800 
Phe Ala Leu Val Gly Lys Gln Leu Leu Gly Glu Asn Tyr Arg Asn Asn
                805                 810                 815     
Arg Lys Asn Ile Ser Ala Pro His Glu Asp Trp Pro Arg Trp His Met
            820                 825                 830         
His Asp Phe Phe His Ser Phe Leu Ile Val Phe Arg Ile Leu Cys Gly
        835                 840                 845             
Glu Trp Ile Glu Asn Met Trp Ala Cys Met Glu Val Gly Gln Lys Ser
    850                 855                 860                 
Ile Cys Leu Ile Leu Phe Leu Thr Val Met Val Leu Gly Asn Leu Val
865                 870                 875                 880 
Val Leu Asn Leu Phe Ile Ala Leu Leu Leu Asn Ser Phe Ser Ala Asp
                885                 890                 895     
Asn Leu Thr Ala Pro Glu Asp Asp Gly Glu Val Asn Asn Leu Gln Val
            900                 905                 910         
Ala Leu Ala Arg Ile Gln Val Phe Gly His Arg Thr Lys Gln Ala Leu
        915                 920                 925             
Cys Ser Phe Phe Ser Arg Ser Cys Pro Phe Pro Gln Pro Lys Ala Glu
    930                 935                 940                 
Pro Glu Leu Val Val Lys Leu Pro Leu Ser Ser Ser Lys Ala Glu Asn
945                 950                 955                 960 
His Ile Ala Ala Asn Thr Ala Arg Gly Ser Ser Gly Gly Leu Gln Ala
                965                 970                 975     
Pro Arg Gly Pro Arg Asp Glu His Ser Asp Phe Ile Ala Asn Pro Thr
            980                 985                 990         
Val Trp Val Ser Val Pro Ile Ala Glu Gly Glu Ser Asp Leu Asp Asp
        995                 1000                1005            
Leu Glu Asp Asp Gly Gly Glu Asp Ala Gln Ser Phe Gln Gln Glu Val
    1010                1015                1020                
Ile Pro Lys Gly Gln Gln Glu Gln Leu Gln Gln Val Glu Arg Cys Gly
1025                1030                1035                1040
Asp His Leu Thr Pro Arg Ser Pro Gly Thr Gly Thr Ser Ser Glu Asp
                1045                1050                1055    
Leu Ala Pro Ser Leu Gly Glu Thr Trp Lys Asp Glu Ser Val Pro Gln
            1060                1065                1070        
Ala Pro Ala Glu Gly Val Asp Asp Thr Ser Ser Ser Glu Gly Ser Thr
        1075                1080                1085            
Val Asp Cys Leu Asp Pro Glu Glu Ile Leu Arg Lys Ile Pro Glu Leu
    1090                1095                1100                
Ala Asp Asp Leu Glu Glu Pro Asp Asp Cys Phe Thr Glu Gly Cys Ile
1105                1110                1115                1120
Arg His Cys Pro Cys Cys Lys Leu Asp Thr Thr Lys Ser Pro Trp Asp
                1125                1130                1135    
Val Gly Trp Gln Val Arg Lys Thr Cys Tyr Arg Ile Val Glu His Ser
            1140                1145                1150        
Trp Phe Glu Ser Phe Ile Ile Phe Met Ile Leu Leu Ser Ser Gly Ser
        1155                1160                1165            
Leu Ala Phe Glu Asp Tyr Tyr Leu Asp Gln Lys Pro Thr Val Lys Ala
    1170                1175                1180                
Leu Leu Glu Tyr Thr Asp Arg Val Phe Thr Phe Ile Phe Val Phe Glu
1185                1190                1195                1200
Met Leu Leu Lys Trp Val Ala Tyr Gly Phe Lys Lys Tyr Phe Thr Asn
                1205                1210                1215    
Ala Trp Cys Trp Leu Asp Phe Leu Ile Val Asn Ile Ser Leu Ile Ser
            1220                1225                1230        
Leu Thr Ala Lys Ile Leu Glu Tyr Ser Glu Val Ala Pro Ile Lys Ala
        1235                1240                1245            
Leu Arg Thr Leu Arg Ala Leu Arg Pro Leu Arg Ala Leu Ser Arg Phe
    1250                1255                1260                
Glu Gly Met Arg Val Val Val Asp Ala Leu Val Gly Ala Ile Pro Ser
1265                1270                1275                1280
Ile Met Asn Val Leu Leu Val Cys Leu Ile Phe Trp Leu Ile Phe Ser
                1285                1290                1295    
Ile Met Gly Val Asn Leu Phe Ala Gly Lys Phe Trp Arg Cys Ile Asn
            1300                1305                1310        
Tyr Thr Asp Gly Glu Phe Ser Leu Val Pro Leu Ser Ile Val Asn Asn
        1315                1320                1325            
Lys Ser Asp Cys Lys Ile Gln Asn Ser Thr Gly Ser Phe Phe Trp Val
    1330                1335                1340                
Asn Val Lys Val Asn Phe Asp Asn Val Ala Met Gly Tyr Leu Ala Leu
1345                1350                1355                1360
Leu Gln Val Ala Thr Phe Lys Gly Trp Met Asp Ile Met Tyr Ala Ala
                1365                1370                1375    
Val Asp Ser Arg Glu Val Asn Met Gln Pro Lys Trp Glu Asp Asn Val
            1380                1385                1390        
Tyr Met Tyr Leu Tyr Phe Val Ile Phe Ile Ile Phe Gly Gly Phe Phe
        1395                1400                1405            
Thr Leu Asn Leu Phe Val Gly Val Ile Ile Asp Asn Phe Asn Gln Gln
    1410                1415                1420                
Lys Lys Lys Leu Gly Gly Gln Asp Ile Phe Met Thr Glu Glu Gln Lys
1425                1430                1435                1440
Lys Tyr Tyr Asn Ala Met Lys Lys Leu Gly Ser Lys Lys Pro Gln Lys
                1445                1450                1455    
Pro Ile Pro Arg Pro Leu Asn Lys Phe Gln Gly Phe Val Phe Asp Ile
            1460                1465                1470        
Val Thr Arg Gln Ala Phe Asp Ile Thr Ile Met Val Leu Ile Cys Leu
        1475                1480                1485            
Asn Met Ile Thr Met Met Val Glu Thr Asp Asp Gln Ser Glu Glu Lys
    1490                1495                1500                
Thr Lys Ile Leu Gly Lys Ile Asn Gln Phe Phe Val Ala Val Phe Thr
1505                1510                1515                1520
Gly Glu Cys Val Met Lys Met Phe Ala Leu Arg Gln Tyr Tyr Phe Thr
                1525                1530                1535    
Asn Gly Trp Asn Val Phe Asp Phe Ile Val Val Val Leu Ser Ile Ala
            1540                1545                1550        
Ser Leu Ile Phe Ser Ala Ile Leu Lys Ser Leu Gln Ser Tyr Phe Ser
        1555                1560                1565            
Pro Thr Leu Phe Arg Val Ile Arg Leu Ala Arg Ile Gly Arg Ile Leu
    1570                1575                1580                
Arg Leu Ile Arg Ala Ala Lys Gly Ile Arg Thr Leu Leu Phe Ala Leu
1585                1590                1595                1600
Met Met Ser Leu Pro Ala Leu Phe Asn Ile Gly Leu Leu Leu Phe Leu
                1605                1610                1615    
Val Met Phe Ile Tyr Ser Ile Phe Gly Met Ser Ser Phe Pro His Val
            1620                1625                1630        
Arg Trp Glu Ala Gly Ile Asp Asp Met Phe Asn Phe Gln Thr Phe Ala
        1635                1640                1645            
Asn Ser Met Leu Cys Leu Phe Gln Ile Thr Thr Ser Ala Gly Trp Asp
    1650                1655                1660                
Gly Leu Leu Ser Pro Ile Leu Asn Thr Gly Pro Pro Tyr Cys Asp Pro
1665                1670                1675                1680
Asn Leu Pro Asn Ser Asn Gly Thr Arg Gly Asp Cys Gly Ser Pro Ala
                1685                1690                1695    
Val Gly Ile Ile Phe Phe Thr Thr Tyr Ile Ile Ile Ser Phe Leu Ile
            1700                1705                1710        
Val Val Asn Met Tyr Ile Ala Val Ile Leu Glu Asn Phe Asn Val Ala
        1715                1720                1725            
Thr Glu Glu Ser Thr Glu Pro Leu Ser Glu Asp Asp Phe Asp Met Phe
    1730                1735                1740                
Tyr Glu Thr Trp Glu Lys Phe Asp Pro Glu Ala Thr Gln Phe Ile Thr
1745                1750                1755                1760
Phe Ser Ala Leu Ser Asp Phe Ala Asp Thr Leu Ser Gly Pro Leu Arg
                1765                1770                1775    
Ile Pro Lys Pro Asn Arg Asn Ile Leu Ile Gln Met Asp Leu Pro Leu
            1780                1785                1790        
Val Pro Gly Asp Lys Ile His Cys Leu Asp Ile Leu Phe Ala Phe Thr
        1795                1800                1805            
Lys Asn Val Leu Gly Glu Ser Gly Glu Leu Asp Ser Leu Lys Ala Asn
    1810                1815                1820                
Met Glu Glu Lys Phe Met Ala Thr Asn Leu Ser Lys Ser Ser Tyr Glu
1825                1830                1835                1840
Pro Ile Ala Thr Thr Leu Arg Trp Lys Gln Glu Asp Ile Ser Ala Thr
                1845                1850                1855    
Val Ile Gln Lys Ala Tyr Arg Ser Tyr Val Leu His Arg Ser Met Ala
            1860                1865                1870        
Leu Ser Asn Thr Pro Cys Val Pro Arg Ala Glu Glu Glu Ala Ala Ser
        1875                1880                1885            
Leu Pro Asp Glu Gly Phe Val Ala Phe Thr Ala Asn Glu Asn Cys Val
    1890                1895                1900                
Leu Pro Asp Lys Ser Glu Thr Ala Ser Ala Thr Ser Phe Pro Pro Ser
1905                1910                1915                1920
Tyr Glu Ser Val Thr Arg Gly Leu Ser Asp Arg Val Asn Met Arg Thr
                1925                1930                1935    
Ser Ser Ser Ile Gln Asn Glu Asp Glu Ala Thr Ser Met Glu Leu Ile
            1940                1945                1950        
Ala Pro Gly Pro
        1955    


<210> 710
<211> 521
<212> PRT
<213> Homo sapiens

<400> 710
Met Glu Cys Pro His Leu Ser Ser Ser Val Cys Ile Ala Pro Asp Ser
 1               5                  10                  15      
Ala Lys Phe Pro Asn Gly Ser Pro Ser Ser Trp Cys Cys Ser Val Cys
            20                  25                  30          
Arg Ser Asn Lys Ser Pro Trp Val Cys Leu Thr Cys Ser Ser Val His
        35                  40                  45              
Cys Gly Arg Tyr Val Asn Gly His Ala Lys Lys His Tyr Glu Asp Ala
    50                  55                  60                  
Gln Val Pro Leu Thr Asn His Lys Lys Ser Glu Lys Gln Asp Lys Val
65                  70                  75                  80  
Gln His Thr Val Cys Met Asp Cys Ser Ser Tyr Ser Thr Tyr Cys Tyr
                85                  90                  95      
Arg Cys Asp Asp Phe Val Val Asn Asp Thr Lys Leu Gly Leu Val Gln
            100                 105                 110         
Lys Val Arg Glu His Leu Gln Asn Leu Glu Asn Ser Ala Phe Thr Ala
        115                 120                 125             
Asp Arg His Lys Lys Arg Lys Leu Leu Glu Asn Ser Thr Leu Asn Ser
    130                 135                 140                 
Lys Leu Leu Lys Val Asn Gly Ser Thr Thr Ala Ile Cys Ala Thr Gly
145                 150                 155                 160 
Leu Arg Asn Leu Gly Asn Thr Cys Phe Met Asn Ala Ile Leu Gln Ser
                165                 170                 175     
Leu Ser Asn Ile Glu Gln Phe Cys Cys Tyr Phe Lys Glu Leu Pro Ala
            180                 185                 190         
Val Glu Leu Arg Asn Gly Lys Thr Ala Gly Arg Arg Thr Tyr His Thr
        195                 200                 205             
Arg Ser Gln Gly Asp Asn Asn Val Ser Leu Val Glu Glu Phe Arg Lys
    210                 215                 220                 
Thr Leu Cys Ala Leu Trp Gln Gly Ser Gln Thr Ala Phe Ser Pro Glu
225                 230                 235                 240 
Ser Leu Phe Tyr Val Val Trp Lys Ile Met Pro Asn Phe Arg Gly Tyr
                245                 250                 255     
Gln Gln Gln Asp Ala His Glu Phe Asn Ala Leu Pro Phe Gly Pro Pro
            260                 265                 270         
Thr Leu Gly Asn Phe Arg Ala Val Ser Thr Val Phe Pro Ala Gln Gln
        275                 280                 285             
Phe Cys Arg Arg Ile Leu Leu Cys Leu Gln Val Asn Lys Cys Cys Ile
    290                 295                 300                 
Asn Gly Ala Ser Thr Val Val Thr Ala Ile Phe Gly Gly Ile Leu Gln
305                 310                 315                 320 
Asn Glu Val Asn Cys Leu Ile Cys Gly Thr Glu Ser Arg Lys Phe Asp
                325                 330                 335     
Pro Phe Leu Asp Leu Ser Leu Asp Ile Pro Ser Gln Phe Arg Ser Lys
            340                 345                 350         
Arg Ser Lys Asn Gln Glu Asn Gly Pro Val Cys Ser Leu Arg Asp Cys
        355                 360                 365             
Leu Arg Ser Phe Thr Asp Leu Glu Glu Leu Asp Glu Thr Glu Leu Tyr
    370                 375                 380                 
Met Cys His Lys Cys Lys Lys Lys Gln Lys Ser Thr Lys Lys Phe Trp
385                 390                 395                 400 
Ile Gln Lys Leu Pro Lys Val Leu Cys Leu His Leu Lys Arg Phe His
                405                 410                 415     
Trp Thr Ala Tyr Leu Arg Asn Lys Val Asp Thr Tyr Val Glu Phe Pro
            420                 425                 430         
Leu Arg Gly Leu Asp Met Lys Trp Tyr Leu Leu Glu Pro Glu Asn Ser
        435                 440                 445             
Gly Pro Glu Ser Cys Leu Tyr Asp Leu Ala Ala Val Val Val His His
    450                 455                 460                 
Gly Ser Gly Val Gly Ser Gly His Tyr Thr Ala Tyr Ala Thr His Glu
465                 470                 475                 480 
Gly Arg Trp Phe His Phe Asn Asp Ser Thr Val Thr Leu Thr Asp Glu
                485                 490                 495     
Glu Thr Val Val Lys Ala Lys Ala Tyr Ile Leu Phe Tyr Val Glu His
            500                 505                 510         
Gln Ala Lys Ala Gly Ser Asp Lys Leu
        515                 520     


<210> 711
<211> 664
<212> PRT
<213> Homo sapiens

<400> 711
Met Ser Gly Val Arg Gly Leu Ser Arg Leu Leu Ser Ala Arg Arg Leu
 1               5                  10                  15      
Ala Leu Ala Lys Ala Trp Pro Thr Val Leu Gln Thr Gly Thr Arg Gly
            20                  25                  30          
Phe His Phe Thr Val Asp Gly Asn Lys Arg Ala Ser Ala Lys Val Ser
        35                  40                  45              
Asp Ser Ile Ser Ala Gln Tyr Pro Val Val Asp His Glu Phe Asp Ala
    50                  55                  60                  
Val Val Val Gly Ala Gly Gly Ala Gly Leu Arg Ala Ala Phe Gly Leu
65                  70                  75                  80  
Ser Glu Ala Gly Phe Asn Thr Ala Cys Val Thr Lys Leu Phe Pro Thr
                85                  90                  95      
Arg Ser His Thr Val Ala Ala Gln Gly Gly Ile Asn Ala Ala Leu Gly
            100                 105                 110         
Asn Met Glu Glu Asp Asn Trp Arg Trp His Phe Tyr Asp Thr Val Lys
        115                 120                 125             
Gly Ser Asp Trp Leu Gly Asp Gln Asp Ala Ile His Tyr Met Thr Glu
    130                 135                 140                 
Gln Ala Pro Ala Ala Val Val Glu Leu Glu Asn Tyr Gly Met Pro Phe
145                 150                 155                 160 
Ser Arg Thr Glu Asp Gly Lys Ile Tyr Gln Arg Ala Phe Gly Gly Gln
                165                 170                 175     
Ser Leu Lys Phe Gly Lys Gly Gly Gln Ala His Arg Cys Cys Cys Val
            180                 185                 190         
Ala Asp Arg Thr Gly His Ser Leu Leu His Thr Leu Tyr Gly Arg Ser
        195                 200                 205             
Leu Arg Tyr Asp Thr Ser Tyr Phe Val Glu Tyr Phe Ala Leu Asp Leu
    210                 215                 220                 
Leu Met Glu Asn Gly Glu Cys Arg Gly Val Ile Ala Leu Cys Ile Glu
225                 230                 235                 240 
Asp Gly Ser Ile His Arg Ile Arg Ala Lys Asn Thr Val Val Ala Thr
                245                 250                 255     
Gly Gly Tyr Gly Arg Thr Tyr Phe Ser Cys Thr Ser Ala His Thr Ser
            260                 265                 270         
Thr Gly Asp Gly Thr Ala Met Ile Thr Arg Ala Gly Leu Pro Cys Gln
        275                 280                 285             
Asp Leu Glu Phe Val Gln Phe His Pro Thr Gly Ile Tyr Gly Ala Gly
    290                 295                 300                 
Cys Leu Ile Thr Glu Gly Cys Arg Gly Glu Gly Gly Ile Leu Ile Asn
305                 310                 315                 320 
Ser Gln Gly Glu Arg Phe Met Glu Arg Tyr Ala Pro Val Ala Lys Asp
                325                 330                 335     
Leu Ala Ser Arg Asp Val Val Ser Arg Ser Met Thr Leu Glu Ile Arg
            340                 345                 350         
Glu Gly Arg Asp Cys Gly Pro Glu Lys Asp His Val Tyr Leu Gln Leu
        355                 360                 365             
His His Leu Pro Pro Glu Gln Leu Ala Thr Arg Leu Pro Gly Ile Ser
    370                 375                 380                 
Glu Thr Ala Met Ile Phe Ala Gly Val Asp Val Thr Lys Asp Pro Ile
385                 390                 395                 400 
Pro Val Leu Pro Thr Val His Tyr Asn Met Gly Gly Ile Pro Thr Asn
                405                 410                 415     
Tyr Lys Gly Gln Val Leu Arg His Val Asn Gly Gln Asp Gln Ile Val
            420                 425                 430         
Pro Gly Leu Tyr Ala Cys Gly Glu Ala Ala Cys Ala Ser Val His Gly
        435                 440                 445             
Ala Asn Arg Leu Gly Ala Asn Ser Leu Leu Asp Leu Val Val Phe Gly
    450                 455                 460                 
Arg Ala Cys Ala Leu Ser Ile Glu Glu Ser Cys Arg Pro Gly Asp Lys
465                 470                 475                 480 
Val Pro Pro Ile Lys Pro Asn Ala Gly Glu Glu Ser Val Met Asn Leu
                485                 490                 495     
Asp Lys Leu Arg Phe Ala Asp Gly Ser Ile Arg Thr Ser Glu Leu Arg
            500                 505                 510         
Leu Ser Met Gln Lys Ser Met Gln Asn His Ala Ala Val Phe Arg Val
        515                 520                 525             
Gly Ser Val Leu Gln Glu Gly Cys Gly Lys Ile Ser Lys Leu Tyr Gly
    530                 535                 540                 
Asp Leu Lys His Leu Lys Thr Phe Asp Arg Gly Met Val Trp Asn Thr
545                 550                 555                 560 
Asp Leu Val Glu Thr Leu Glu Leu Gln Asn Leu Met Leu Cys Ala Leu
                565                 570                 575     
Gln Thr Ile Tyr Gly Ala Glu Ala Arg Lys Glu Ser Arg Gly Thr His
            580                 585                 590         
Ala Arg Glu Gly Tyr Lys Val Gln Ile Asp Glu Tyr Asp Tyr Ser Lys
        595                 600                 605             
Pro Ile Gln Gly Gln Gln Lys Lys Pro Phe Glu Glu His Trp Arg Lys
    610                 615                 620                 
His Thr Leu Ser Tyr Val Asp Val Gly Thr Gly Lys Val Thr Leu Gly
625                 630                 635                 640 
Tyr Arg Pro Val Ile Asp Lys Thr Leu Asn Glu Ala Asp Cys Ala Thr
                645                 650                 655     
Val Pro Pro Ala Ile Arg Ser Tyr
            660                 


<210> 712
<211> 798
<212> PRT
<213> Homo sapiens

<400> 712
Met Ala Trp Asp Met Cys Asn Gln Asp Ser Glu Ser Val Trp Ser Asp
 1               5                  10                  15      
Ile Glu Cys Ala Ala Leu Val Gly Glu Asp Gln Pro Leu Cys Pro Asp
            20                  25                  30          
Leu Pro Glu Leu Asp Leu Ser Glu Leu Asp Val Asn Asp Leu Asp Thr
        35                  40                  45              
Asp Ser Phe Leu Gly Gly Leu Lys Trp Cys Ser Asp Gln Ser Glu Ile
    50                  55                  60                  
Ile Ser Asn Gln Tyr Asn Asn Glu Pro Ser Asn Ile Phe Glu Lys Ile
65                  70                  75                  80  
Asp Glu Glu Asn Glu Ala Asn Leu Leu Ala Val Leu Thr Glu Thr Leu
                85                  90                  95      
Asp Ser Leu Pro Val Asp Glu Asp Gly Leu Pro Ser Phe Asp Ala Leu
            100                 105                 110         
Thr Asp Gly Asp Val Thr Thr Asp Asn Glu Ala Ser Pro Ser Ser Met
        115                 120                 125             
Pro Asp Gly Thr Pro Pro Pro Gln Glu Ala Glu Glu Pro Ser Leu Leu
    130                 135                 140                 
Lys Lys Leu Leu Leu Ala Pro Ala Asn Thr Gln Leu Ser Tyr Asn Glu
145                 150                 155                 160 
Cys Ser Gly Leu Ser Thr Gln Asn His Ala Asn His Asn His Arg Ile
                165                 170                 175     
Arg Thr Asn Pro Ala Ile Val Lys Thr Glu Asn Ser Trp Ser Asn Lys
            180                 185                 190         
Ala Lys Ser Ile Cys Gln Gln Gln Lys Pro Gln Arg Arg Pro Cys Ser
        195                 200                 205             
Glu Leu Leu Lys Tyr Leu Thr Thr Asn Asp Asp Pro Pro His Thr Lys
    210                 215                 220                 
Pro Thr Glu Asn Arg Asn Ser Ser Arg Asp Lys Cys Thr Ser Lys Lys
225                 230                 235                 240 
Lys Ser His Thr Gln Ser Gln Ser Gln His Leu Gln Ala Lys Pro Thr
                245                 250                 255     
Thr Leu Ser Leu Pro Leu Thr Pro Glu Ser Pro Asn Asp Pro Lys Gly
            260                 265                 270         
Ser Pro Phe Glu Asn Lys Thr Ile Glu Arg Thr Leu Ser Val Glu Leu
        275                 280                 285             
Ser Gly Thr Ala Gly Leu Thr Pro Pro Thr Thr Pro Pro His Lys Ala
    290                 295                 300                 
Asn Gln Asp Asn Pro Phe Arg Ala Ser Pro Lys Leu Lys Ser Ser Cys
305                 310                 315                 320 
Lys Thr Val Val Pro Pro Pro Ser Lys Lys Pro Arg Tyr Ser Glu Ser
                325                 330                 335     
Ser Gly Thr Gln Gly Asn Asn Ser Thr Lys Lys Gly Pro Glu Gln Ser
            340                 345                 350         
Glu Leu Tyr Ala Gln Leu Ser Lys Ser Ser Val Leu Thr Gly Gly His
        355                 360                 365             
Glu Glu Arg Lys Thr Lys Arg Pro Ser Leu Arg Leu Phe Gly Asp His
    370                 375                 380                 
Asp Tyr Cys Gln Ser Ile Asn Ser Lys Thr Glu Ile Leu Ile Asn Ile
385                 390                 395                 400 
Ser Gln Glu Leu Gln Asp Ser Arg Gln Leu Glu Asn Lys Asp Val Ser
                405                 410                 415     
Ser Asp Trp Gln Gly Gln Ile Cys Ser Ser Thr Asp Ser Asp Gln Cys
            420                 425                 430         
Tyr Leu Arg Glu Thr Leu Glu Ala Ser Lys Gln Val Ser Pro Cys Ser
        435                 440                 445             
Thr Arg Lys Gln Leu Gln Asp Gln Glu Ile Arg Ala Glu Leu Asn Lys
    450                 455                 460                 
His Phe Gly His Pro Ser Gln Ala Val Phe Asp Asp Glu Ala Asp Lys
465                 470                 475                 480 
Thr Ser Glu Leu Arg Asp Ser Asp Phe Ser Asn Glu Gln Phe Ser Lys
                485                 490                 495     
Leu Pro Met Phe Ile Asn Ser Gly Leu Ala Met Asp Gly Leu Phe Asp
            500                 505                 510         
Asp Ser Glu Asp Glu Ser Asp Lys Leu Ser Tyr Pro Trp Asp Gly Thr
        515                 520                 525             
Gln Ser Tyr Ser Leu Phe Asn Val Ser Pro Ser Cys Ser Ser Phe Asn
    530                 535                 540                 
Ser Pro Cys Arg Asp Ser Val Ser Pro Pro Lys Ser Leu Phe Ser Gln
545                 550                 555                 560 
Arg Pro Gln Arg Met Arg Ser Arg Ser Arg Ser Phe Ser Arg His Arg
                565                 570                 575     
Ser Cys Ser Arg Ser Pro Tyr Ser Arg Ser Arg Ser Arg Ser Pro Gly
            580                 585                 590         
Ser Arg Ser Ser Ser Arg Ser Cys Tyr Tyr Tyr Glu Ser Ser His Tyr
        595                 600                 605             
Arg His Arg Thr His Arg Asn Ser Pro Leu Tyr Val Arg Ser Arg Ser
    610                 615                 620                 
Arg Ser Pro Tyr Ser Arg Arg Pro Arg Tyr Asp Ser Tyr Glu Glu Tyr
625                 630                 635                 640 
Gln His Glu Arg Leu Lys Arg Glu Glu Tyr Arg Arg Glu Tyr Glu Lys
                645                 650                 655     
Arg Glu Ser Glu Arg Ala Lys Gln Arg Glu Arg Gln Arg Gln Lys Ala
            660                 665                 670         
Ile Glu Glu Arg Arg Val Ile Tyr Val Gly Lys Ile Arg Pro Asp Thr
        675                 680                 685             
Thr Arg Thr Glu Leu Arg Asp Arg Phe Glu Val Phe Gly Glu Ile Glu
    690                 695                 700                 
Glu Cys Thr Val Asn Leu Arg Asp Asp Gly Asp Ser Tyr Gly Phe Ile
705                 710                 715                 720 
Thr Tyr Arg Tyr Thr Cys Asp Ala Phe Ala Ala Leu Glu Asn Gly Tyr
                725                 730                 735     
Thr Leu Arg Arg Ser Asn Glu Thr Asp Phe Glu Leu Tyr Phe Cys Gly
            740                 745                 750         
Arg Lys Gln Phe Phe Lys Ser Asn Tyr Ala Asp Leu Asp Ser Asn Ser
        755                 760                 765             
Asp Asp Phe Asp Pro Ala Ser Thr Lys Ser Lys Tyr Asp Ser Leu Asp
    770                 775                 780                 
Phe Asp Ser Leu Leu Lys Glu Ala Gln Arg Ser Leu Arg Arg
785                 790                 795             


<210> 713
<211> 2294
<212> PRT
<213> Homo sapiens

<400> 713
Met Gly Gln Thr Lys Ser Lys Ile Lys Ser Lys Tyr Ala Ser Tyr Leu
 1               5                  10                  15      
Ser Phe Ile Lys Ile Leu Leu Lys Arg Gly Gly Val Lys Val Ser Thr
            20                  25                  30          
Lys Asn Leu Ile Lys Leu Phe Gln Ile Ile Glu Gln Phe Cys Pro Trp
        35                  40                  45              
Phe Pro Glu Gln Gly Thr Leu Asp Leu Lys Asp Trp Lys Arg Ile Gly
    50                  55                  60                  
Lys Glu Leu Lys Gln Ala Gly Arg Lys Gly Asn Ile Ile Pro Leu Thr
65                  70                  75                  80  
Val Trp Asn Asp Trp Ala Ile Ile Lys Ala Ala Leu Glu Pro Phe Gln
                85                  90                  95      
Thr Glu Glu Asp Ser Val Ser Val Ser Asp Ala Pro Gly Ser Cys Leu
            100                 105                 110         
Ile Asp Cys Asn Glu Asn Thr Arg Lys Lys Ser Gln Lys Glu Thr Glu
        115                 120                 125             
Ser Leu His Cys Glu Tyr Val Ala Glu Pro Val Met Ala Gln Ser Thr
    130                 135                 140                 
Gln Asn Val Asp Tyr Asn Gln Leu Gln Glu Val Ile Tyr Pro Glu Thr
145                 150                 155                 160 
Leu Lys Leu Glu Gly Lys Gly Pro Glu Leu Val Gly Pro Ser Glu Ser
                165                 170                 175     
Lys Pro Arg Gly Thr Ser Pro Leu Pro Ala Gly Gln Val Pro Val Arg
            180                 185                 190         
Leu Gln Pro Gln Lys Gln Val Lys Glu Asn Lys Thr Gln Pro Pro Val
        195                 200                 205             
Ala Tyr Gln Tyr Trp Pro Pro Ala Glu Leu Gln Tyr Arg Pro Pro Pro
    210                 215                 220                 
Glu Ser Gln Tyr Gly Tyr Pro Gly Met Pro Pro Ala Pro Gln Gly Arg
225                 230                 235                 240 
Ala Pro Tyr Pro Gln Pro Pro Thr Arg Arg Leu Asn Pro Thr Ala Pro
                245                 250                 255     
Pro Ser Arg Gln Gly Ser Glu Leu His Glu Ile Ile Asp Lys Ser Arg
            260                 265                 270         
Lys Glu Gly Asp Thr Glu Ala Trp Gln Phe Pro Ile Thr Leu Glu Pro
        275                 280                 285             
Met Pro Pro Gly Glu Gly Ala Gln Glu Gly Glu Pro Pro Thr Val Glu
    290                 295                 300                 
Ala Arg Tyr Lys Ser Phe Ser Ile Lys Met Leu Lys Asp Met Lys Glu
305                 310                 315                 320 
Gly Val Lys Gln Tyr Gly Pro Asn Ser Pro Tyr Met Arg Thr Leu Leu
                325                 330                 335     
Asp Ser Ile Ala Tyr Gly His Arg Leu Ile Pro Tyr Asp Trp Glu Ile
            340                 345                 350         
Leu Ala Lys Ser Ser Leu Ser Pro Ser Gln Phe Leu Gln Phe Lys Thr
        355                 360                 365             
Trp Trp Ile Asp Gly Val Gln Glu Gln Val Arg Arg Asn Arg Ala Ala
    370                 375                 380                 
Asn Pro Pro Val Asn Ile Asp Ala Asp Gln Leu Leu Gly Ile Gly Gln
385                 390                 395                 400 
Asn Trp Ser Thr Ile Ser Gln Gln Ala Leu Met Gln Asn Glu Ala Ile
                405                 410                 415     
Glu Gln Val Arg Ala Ile Cys Leu Arg Ala Trp Glu Lys Ile Gln Asp
            420                 425                 430         
Pro Gly Ser Thr Cys Pro Ser Phe Asn Thr Val Arg Gln Gly Ser Lys
        435                 440                 445             
Glu Pro Tyr Pro Asp Phe Val Ala Arg Leu Gln Asp Val Ala Gln Lys
    450                 455                 460                 
Ser Ile Ala Asp Glu Lys Ala His Lys Val Ile Val Glu Leu Met Ala
465                 470                 475                 480 
Tyr Glu Asn Ala Asn Pro Glu Cys Gln Ser Ala Ile Lys Pro Leu Lys
                485                 490                 495     
Gly Lys Val Pro Ala Gly Ser Asp Val Ile Ser Glu Tyr Val Lys Ala
            500                 505                 510         
Cys Asp Gly Ile Gly Gly Ala Met His Lys Ala Met Leu Met Ala Gln
        515                 520                 525             
Ala Ile Thr Gly Val Val Leu Gly Gly Gln Val Arg Thr Phe Gly Gly
    530                 535                 540                 
Lys Cys Tyr Asn Cys Gly Gln Ile Gly His Leu Lys Lys Asn Cys Pro
545                 550                 555                 560 
Val Leu Asn Lys Gln Asn Ile Thr Ile Gln Ala Thr Thr Thr Gly Arg
                565                 570                 575     
Glu Pro Pro Asp Leu Cys Pro Arg Cys Lys Lys Gly Lys His Trp Ala
            580                 585                 590         
Ser Gln Cys Arg Ser Lys Phe Asp Lys Asn Gly Gln Pro Leu Ser Gly
        595                 600                 605             
Asn Glu Gln Arg Gly Gln Pro Gln Ala Pro Gln Gln Thr Gly Ala Phe
    610                 615                 620                 
Pro Val Gln Pro Phe Val Pro Gln Gly Phe Gln Gly Gln Gln Pro Pro
625                 630                 635                 640 
Leu Ser Gln Val Phe Gln Gly Ile Ser Gln Leu Pro Gln Tyr Asn Asn
                645                 650                 655     
Cys Pro Ser Pro Gln Ala Ala Val Gln Gln Val Asp Leu Cys Thr Ile
            660                 665                 670         
Gln Ala Val Ser Leu Leu Pro Gly Glu Pro Pro Gln Lys Ile Pro Thr
        675                 680                 685             
Gly Val Tyr Gly Pro Leu Pro Lys Gly Thr Val Gly Leu Ile Leu Gly
    690                 695                 700                 
Arg Ser Ser Leu Asn Leu Lys Gly Val Gln Ile His Thr Ser Val Val
705                 710                 715                 720 
Asp Ser Asp Tyr Lys Gly Glu Ile Gln Leu Val Ile Ser Ser Ser Ile
                725                 730                 735     
Pro Trp Ser Ala Ser Pro Gly Asp Arg Ile Ala Gln Leu Leu Leu Leu
            740                 745                 750         
Pro Tyr Ile Lys Gly Gly Asn Ser Glu Leu Lys Lys Ile Gly Gly Leu
        755                 760                 765             
Gly Ser Thr Asp Pro Thr Gly Lys Ala Ala Tyr Trp Ala Ser Gln Val
    770                 775                 780                 
Ser Glu Asn Arg Pro Val Cys Lys Ala Ile Ile Gln Gly Lys Gln Phe
785                 790                 795                 800 
Glu Gly Leu Val Asp Thr Gly Ala Asp Val Ser Ile Ile Ala Leu Asn
                805                 810                 815     
Gln Trp Pro Lys Asn Trp Pro Lys Gln Lys Ala Val Thr Gly Leu Val
            820                 825                 830         
Gly Ile Gly Thr Ala Ser Glu Val Tyr Gln Ser Thr Glu Ile Leu His
        835                 840                 845             
Cys Leu Gly Pro Asp Asn Gln Glu Ser Thr Val Gln Pro Met Ile Thr
    850                 855                 860                 
Ser Ile Pro Leu Asn Leu Trp Gly Arg Asp Leu Leu Gln Gln Trp Gly
865                 870                 875                 880 
Ala Glu Ile Thr Met Pro Ala Pro Leu Tyr Ser Pro Thr Ser Gln Lys
                885                 890                 895     
Ile Met Thr Lys Arg Gly Tyr Ile Pro Gly Lys Gly Leu Gly Lys Asn
            900                 905                 910         
Glu Asp Gly Ile Lys Ile Pro Phe Glu Ala Lys Ile Asn Gln Glu Arg
        915                 920                 925             
Glu Gly Ile Gly Tyr Pro Phe Leu Gly Ala Ala Thr Val Glu Pro Pro
    930                 935                 940                 
Lys Pro Ile Pro Leu Thr Trp Lys Thr Glu Lys Pro Val Trp Val Asn
945                 950                 955                 960 
Gln Trp Pro Leu Pro Lys Gln Lys Leu Glu Ala Leu His Leu Leu Ala
                965                 970                 975     
Asn Glu Gln Leu Glu Lys Gly His Ile Glu Pro Ser Phe Ser Pro Trp
            980                 985                 990         
Asn Ser Pro Val Phe Val Ile Gln Lys Lys Ser Gly Lys Trp Arg Met
        995                 1000                1005            
Leu Thr Asp Leu Arg Ala Val Asn Ala Leu Ile Gln Pro Met Gly Pro
    1010                1015                1020                
Leu Gln Pro Gly Leu Pro Ser Pro Ala Met Ile Pro Lys Asp Trp Pro
1025                1030                1035                1040
Leu Ile Ile Ile Asp Leu Lys Asp Cys Phe Phe Thr Ile Pro Leu Ala
                1045                1050                1055    
Glu Gln Asp Cys Glu Lys Phe Ala Phe Thr Ile Pro Ala Ile Asn Asn
            1060                1065                1070        
Lys Glu Pro Ala Thr Arg Phe Gln Trp Lys Val Leu Pro Gln Gly Met
        1075                1080                1085            
Leu Asn Ser Pro Thr Ile Cys Gln Thr Phe Val Gly Arg Ala Leu Gln
    1090                1095                1100                
Pro Val Arg Glu Lys Phe Ser Asp Cys Tyr Ile Ile His Tyr Ile Asp
1105                1110                1115                1120
Asp Ile Leu Cys Ala Ala Glu Thr Lys Asp Lys Leu Ile Asp Cys Tyr
                1125                1130                1135    
Thr Phe Leu Gln Ala Glu Val Ala Asn Ala Gly Leu Ala Ile Ala Ser
            1140                1145                1150        
Asp Lys Ile Gln Thr Ser Thr Pro Phe His Tyr Leu Gly Met Gln Ile
        1155                1160                1165            
Glu Asn Arg Lys Ile Lys Pro Gln Lys Ile Glu Ile Arg Lys Asp Thr
    1170                1175                1180                
Leu Lys Thr Leu Asn Asp Phe Gln Lys Leu Leu Gly Asp Ile Asn Trp
1185                1190                1195                1200
Ile Arg Pro Thr Leu Gly Ile Pro Thr Tyr Ala Met Ser Asn Leu Phe
                1205                1210                1215    
Ser Ile Leu Arg Gly Asp Ser Asp Leu Asn Ser Lys Arg Ile Leu Thr
            1220                1225                1230        
Pro Glu Ala Thr Lys Glu Ile Lys Leu Val Glu Glu Lys Ile Gln Ser
        1235                1240                1245            
Ala Gln Ile Asn Arg Ile Gly Pro Leu Ala Pro Leu Gln Leu Leu Ile
    1250                1255                1260                
Phe Ala Thr Ala His Ser Pro Thr Gly Ile Ile Ile Gln Asn Thr Asp
1265                1270                1275                1280
Leu Val Glu Trp Ser Phe Leu Pro His Ser Thr Val Lys Thr Phe Thr
                1285                1290                1295    
Leu Tyr Leu Asp Gln Ile Ala Thr Leu Ile Gly Gln Thr Arg Leu Arg
            1300                1305                1310        
Ile Thr Lys Leu Cys Gly Asn Asp Pro Asp Lys Ile Val Val Pro Leu
        1315                1320                1325            
Thr Lys Glu Gln Val Arg Gln Ala Phe Ile Asn Ser Gly Ala Trp Gln
    1330                1335                1340                
Ile Gly Leu Ala Asn Phe Val Gly Ile Ile Asp Asn His Tyr Pro Lys
1345                1350                1355                1360
Thr Lys Ile Phe Gln Phe Leu Lys Leu Thr Thr Trp Ile Leu Pro Lys
                1365                1370                1375    
Ile Thr Arg Cys Glu Pro Leu Glu Asn Ala Leu Thr Val Phe Thr Asp
            1380                1385                1390        
Gly Ser Ser Asn Gly Lys Ala Ala Tyr Thr Gly Pro Lys Glu Arg Val
        1395                1400                1405            
Ile Lys Thr Pro Tyr Gln Ser Ala Gln Arg Ala Glu Leu Val Ala Val
    1410                1415                1420                
Ile Thr Val Leu Gln Asp Phe Asp Gln Pro Ile Asn Ile Ile Ser Asp
1425                1430                1435                1440
Ser Ala Tyr Val Val Gln Ala Thr Arg Asp Val Glu Thr Ala Leu Ile
                1445                1450                1455    
Lys Tyr Ser Met Asp Asp Gln Leu Asn Gln Leu Phe Asn Leu Leu Gln
            1460                1465                1470        
Gln Thr Val Arg Lys Arg Asn Phe Pro Phe Tyr Ile Thr His Ile Arg
        1475                1480                1485            
Ala His Thr Asn Leu Pro Gly Pro Leu Thr Lys Ala Asn Glu Gln Ala
    1490                1495                1500                
Asp Leu Leu Val Ser Ser Ala Leu Ile Lys Ala Gln Glu Leu His Ala
1505                1510                1515                1520
Leu Thr His Val Asn Ala Ala Gly Leu Lys Asn Lys Phe Asp Val Thr
                1525                1530                1535    
Trp Lys Gln Ala Lys Asp Ile Val Gln His Cys Thr Gln Cys Gln Val
            1540                1545                1550        
Leu His Leu Pro Thr Gln Glu Ala Gly Val Asn Pro Arg Gly Leu Cys
        1555                1560                1565            
Pro Asn Ala Leu Trp Gln Met Asp Val Thr His Val Pro Ser Phe Gly
    1570                1575                1580                
Arg Leu Ser Tyr Val His Val Thr Val Asp Thr Tyr Ser His Phe Ile
1585                1590                1595                1600
Trp Ala Thr Cys Gln Thr Gly Glu Ser Thr Ser His Val Lys Lys His
                1605                1610                1615    
Leu Leu Ser Cys Phe Ala Val Met Gly Val Pro Glu Lys Ile Lys Thr
            1620                1625                1630        
Asp Asn Gly Pro Gly Tyr Cys Ser Lys Ala Phe Gln Lys Phe Leu Ser
        1635                1640                1645            
Gln Trp Lys Ile Ser His Thr Thr Gly Ile Pro Tyr Asn Ser Gln Gly
    1650                1655                1660                
Gln Ala Ile Val Glu Arg Thr Asn Arg Thr Leu Lys Thr Gln Leu Val
1665                1670                1675                1680
Lys Gln Lys Glu Gly Gly Asp Ser Lys Glu Cys Thr Thr Pro Gln Met
                1685                1690                1695    
Gln Leu Asn Leu Ala Leu Tyr Thr Leu Asn Phe Leu Asn Ile Tyr Arg
            1700                1705                1710        
Asn Gln Thr Thr Thr Ser Ala Glu Gln His Leu Thr Gly Lys Lys Asn
        1715                1720                1725            
Ser Pro His Glu Gly Lys Leu Ile Trp Trp Lys Asp Asn Lys Asn Lys
    1730                1735                1740                
Thr Trp Glu Ile Gly Lys Val Ile Thr Trp Gly Arg Gly Phe Ala Cys
1745                1750                1755                1760
Val Ser Pro Gly Glu Asn Gln Leu Pro Val Trp Leu Pro Thr Arg His
                1765                1770                1775    
Leu Lys Phe Tyr Asn Glu Pro Ile Gly Asp Ala Lys Lys Arg Ala Ser
            1780                1785                1790        
Thr Glu Met Val Thr Pro Val Thr Trp Met Asp Asn Pro Ile Glu Val
        1795                1800                1805            
Tyr Val Asn Asp Ser Val Trp Val Pro Gly Pro Ile Asp Asp Arg Cys
    1810                1815                1820                
Pro Ala Lys Pro Glu Glu Glu Gly Met Met Ile Asn Ile Ser Ile Gly
1825                1830                1835                1840
Tyr Arg Tyr Pro Pro Ile Cys Leu Gly Arg Ala Pro Gly Cys Leu Met
                1845                1850                1855    
Pro Ala Val Gln Asn Trp Leu Val Glu Val Pro Thr Val Ser Pro Ile
            1860                1865                1870        
Ser Arg Phe Thr Tyr His Met Val Ser Gly Met Ser Leu Arg Pro Arg
        1875                1880                1885            
Val Asn Tyr Leu Gln Asp Phe Ser Tyr Gln Arg Ser Leu Lys Phe Arg
    1890                1895                1900                
Pro Lys Gly Lys Pro Cys Pro Lys Lys Ile Pro Lys Glu Ser Lys Asn
1905                1910                1915                1920
Thr Glu Val Leu Val Trp Glu Glu Cys Val Asp Asn Ser Ala Val Ile
                1925                1930                1935    
Leu Gln Asn Asn Glu Phe Gly Thr Ile Ile Asp Trp Ala Pro Arg Gly
            1940                1945                1950        
Gln Phe Tyr His Asn Cys Ser Gly Gln Thr Gln Ser Cys Pro Ser Ala
        1955                1960                1965            
Gln Val Ser Pro Ala Val Asp Ser Asp Leu Thr Glu Ser Leu Asp Lys
    1970                1975                1980                
His Lys His Lys Lys Leu Gln Ser Phe Tyr Pro Trp Glu Trp Gly Glu
1985                1990                1995                2000
Lys Gly Ile Ser Thr Pro Arg Pro Lys Ile Ile Ser Pro Val Ser Gly
                2005                2010                2015    
Pro Glu His Pro Glu Leu Trp Arg Leu Thr Val Ala Ser His His Ile
            2020                2025                2030        
Arg Ile Trp Ser Gly Asn Gln Thr Leu Glu Thr Arg Asp Arg Lys Pro
        2035                2040                2045            
Phe Tyr Thr Val Asp Leu Asn Ser Ser Leu Thr Leu Pro Leu Gln Arg
    2050                2055                2060                
Cys Val Lys Pro Pro Tyr Met Leu Val Val Gly Asn Ile Val Ile Lys
2065                2070                2075                2080
Pro Asp Ser Gln Thr Ile Thr Cys Glu Asn Cys Arg Leu Leu Thr Cys
                2085                2090                2095    
Ile Asp Ser Thr Phe Asn Trp Gln His Arg Ile Leu Leu Val Arg Ala
            2100                2105                2110        
Arg Glu Gly Val Trp Ile Pro Val Ser Met Asp Arg Pro Trp Glu Ala
        2115                2120                2125            
Ser Pro Ser Ile His Ile Leu Thr Glu Val Leu Lys Gly Val Leu Asn
    2130                2135                2140                
Arg Ser Lys Arg Phe Ile Phe Thr Leu Ile Ala Val Ile Met Gly Leu
2145                2150                2155                2160
Ile Ala Val Thr Ala Thr Ala Ala Val Ala Gly Val Ala Leu His Ser
                2165                2170                2175    
Ser Val Gln Ser Val Asn Phe Val Asn Asp Trp Gln Lys Asn Ser Thr
            2180                2185                2190        
Arg Leu Trp Asn Ser Gln Ser Ser Ile Asp Gln Lys Leu Ala Asn Gln
        2195                2200                2205            
Ile Asn Asp Leu Arg Gln Thr Val Ile Trp Met Gly Asp Arg Leu Met
    2210                2215                2220                
Ser Leu Glu His Arg Phe Gln Leu Gln Cys Asp Trp Asn Thr Ser Asp
2225                2230                2235                2240
Phe Cys Ile Thr Pro Gln Ile Tyr Asn Glu Ser Glu His His Trp Asp
                2245                2250                2255    
Met Val Arg Arg His Leu Gln Gly Arg Glu Asp Asn Leu Thr Leu Asp
            2260                2265                2270        
Ile Ser Lys Ile Lys Arg Thr Asn Phe Arg Ser Ile Lys Ser Pro Phe
        2275                2280                2285            
Lys Phe Gly Ala Arg Asn
    2290                


<210> 714
<211> 797
<212> PRT
<213> Homo sapiens

<400> 714
Met Ala His Arg Cys Leu Arg Leu Trp Gly Arg Gly Gly Cys Trp Pro
 1               5                  10                  15      
Arg Gly Leu Gln Gln Leu Leu Val Pro Gly Gly Val Gly Pro Gly Glu
            20                  25                  30          
Gln Pro Cys Leu Arg Thr Leu Tyr Arg Phe Val Thr Thr Gln Ala Arg
        35                  40                  45              
Ala Ser Arg Asn Ser Leu Leu Thr Asp Ile Ile Ala Ala Tyr Gln Arg
    50                  55                  60                  
Phe Cys Ser Arg Pro Pro Lys Gly Phe Gly Lys Tyr Phe Pro Asn Gly
65                  70                  75                  80  
Lys Asn Gly Lys Lys Ala Ser Glu Pro Lys Glu Val Met Gly Glu Lys
                85                  90                  95      
Lys Glu Ser Lys Pro Ala Ala Thr Thr Arg Ser Ser Gly Gly Gly Gly
            100                 105                 110         
Gly Gly Gly Gly Lys Arg Gly Gly Lys Lys Asp Asp Ser His Trp Trp
        115                 120                 125             
Ser Arg Phe Gln Lys Gly Asp Ile Pro Trp Asp Asp Lys Asp Phe Arg
    130                 135                 140                 
Met Phe Phe Leu Trp Thr Ala Leu Phe Trp Gly Gly Val Met Phe Tyr
145                 150                 155                 160 
Leu Leu Leu Lys Arg Ser Gly Arg Glu Ile Thr Trp Lys Asp Phe Val
                165                 170                 175     
Asn Asn Tyr Leu Ser Lys Gly Val Val Asp Arg Leu Glu Val Val Asn
            180                 185                 190         
Lys Arg Phe Val Arg Val Thr Phe Thr Pro Gly Lys Thr Pro Val Asp
        195                 200                 205             
Gly Gln Tyr Val Trp Phe Asn Ile Gly Ser Val Asp Thr Phe Glu Arg
    210                 215                 220                 
Asn Leu Glu Thr Leu Gln Gln Glu Leu Gly Ile Glu Gly Glu Asn Arg
225                 230                 235                 240 
Val Pro Val Val Tyr Ile Ala Glu Ser Asp Gly Ser Phe Leu Leu Ser
                245                 250                 255     
Met Leu Pro Thr Val Leu Ile Ile Ala Phe Leu Leu Tyr Thr Ile Arg
            260                 265                 270         
Arg Gly Pro Ala Gly Ile Gly Arg Thr Gly Arg Gly Met Gly Gly Leu
        275                 280                 285             
Phe Ser Val Gly Glu Thr Thr Ala Lys Val Leu Lys Asp Glu Ile Asp
    290                 295                 300                 
Val Lys Phe Lys Asp Val Ala Gly Cys Glu Glu Ala Lys Leu Glu Ile
305                 310                 315                 320 
Met Glu Phe Val Asn Phe Leu Lys Asn Pro Lys Gln Tyr Gln Asp Leu
                325                 330                 335     
Gly Ala Lys Ile Pro Lys Gly Ala Ile Leu Thr Gly Pro Pro Gly Thr
            340                 345                 350         
Gly Lys Thr Leu Leu Ala Lys Ala Thr Ala Gly Glu Ala Asn Val Pro
        355                 360                 365             
Phe Ile Thr Val Ser Gly Ser Glu Phe Leu Glu Met Phe Val Gly Val
    370                 375                 380                 
Gly Pro Ala Arg Val Arg Asp Leu Phe Ala Leu Ala Arg Lys Asn Ala
385                 390                 395                 400 
Pro Cys Ile Leu Phe Ile Asp Glu Ile Asp Ala Val Gly Arg Lys Arg
                405                 410                 415     
Gly Arg Gly Asn Phe Gly Gly Gln Ser Glu Gln Glu Asn Thr Leu Asn
            420                 425                 430         
Gln Leu Leu Val Glu Met Asp Gly Phe Asn Thr Thr Thr Asn Val Val
        435                 440                 445             
Ile Leu Ala Gly Thr Asn Arg Pro Asp Ile Leu Asp Pro Ala Leu Leu
    450                 455                 460                 
Arg Pro Gly Arg Phe Asp Arg Gln Ile Phe Ile Gly Pro Pro Asp Ile
465                 470                 475                 480 
Lys Gly Arg Ala Ser Ile Phe Lys Val His Leu Arg Pro Leu Lys Leu
                485                 490                 495     
Asp Ser Thr Leu Glu Lys Asp Lys Leu Ala Arg Lys Leu Ala Ser Leu
            500                 505                 510         
Thr Pro Gly Phe Ser Gly Ala Asp Val Ala Asn Val Cys Asn Glu Ala
        515                 520                 525             
Ala Leu Ile Ala Ala Arg His Leu Ser Asp Ser Ile Asn Gln Lys His
    530                 535                 540                 
Phe Glu Gln Ala Ile Glu Arg Val Ile Gly Gly Leu Glu Lys Lys Thr
545                 550                 555                 560 
Gln Val Leu Gln Pro Glu Glu Lys Lys Thr Val Ala Tyr His Glu Ala
                565                 570                 575     
Gly His Ala Val Ala Gly Trp Tyr Leu Glu His Ala Asp Pro Leu Leu
            580                 585                 590         
Lys Val Ser Ile Ile Pro Arg Gly Lys Gly Leu Gly Tyr Ala Gln Tyr
        595                 600                 605             
Leu Pro Lys Glu Gln Tyr Leu Tyr Thr Lys Glu Gln Leu Leu Asp Arg
    610                 615                 620                 
Met Cys Met Thr Leu Gly Gly Arg Ala Ser Glu Glu Ile Phe Phe Gly
625                 630                 635                 640 
Arg Ile Thr Thr Gly Ala Gln Asp Asp Leu Arg Lys Val Thr Gln Ser
                645                 650                 655     
Ala Tyr Ala Gln Ile Val Gln Phe Gly Met Asn Glu Lys Val Gly Gln
            660                 665                 670         
Ile Ser Phe Asp Leu Pro Arg Gln Gly Asp Met Val Leu Glu Lys Pro
        675                 680                 685             
Tyr Ser Glu Ala Thr Ala Arg Leu Ile Asp Asp Glu Val Arg Ile Leu
    690                 695                 700                 
Ile Asn Asp Ala Tyr Lys Arg Thr Val Ala Leu Leu Thr Glu Lys Lys
705                 710                 715                 720 
Ala Asp Val Glu Lys Val Ala Leu Leu Leu Leu Glu Lys Glu Val Leu
                725                 730                 735     
Asp Lys Asn Asp Met Val Glu Leu Leu Gly Pro Arg Pro Phe Ala Glu
            740                 745                 750         
Lys Ser Thr Tyr Glu Glu Phe Val Glu Gly Thr Gly Ser Leu Asp Glu
        755                 760                 765             
Asp Thr Ser Leu Pro Glu Gly Leu Lys Asp Trp Asn Lys Glu Arg Glu
    770                 775                 780                 
Lys Glu Lys Glu Glu Pro Pro Gly Glu Lys Val Ala Asn
785                 790                 795         


<210> 715
<211> 758
<212> PRT
<213> Homo sapiens

<400> 715
Met Leu Arg Ala Cys Gln Leu Ser Gly Val Thr Ala Ala Ala Gln Ser
 1               5                  10                  15      
Cys Leu Cys Gly Lys Phe Val Leu Arg Pro Leu Arg Pro Cys Arg Arg
            20                  25                  30          
Tyr Ser Thr Ser Gly Ser Ser Gly Leu Thr Thr Gly Lys Ile Ala Gly
        35                  40                  45              
Ala Gly Leu Leu Phe Val Gly Gly Gly Ile Gly Gly Thr Ile Leu Tyr
    50                  55                  60                  
Ala Lys Trp Asp Ser His Phe Arg Glu Ser Val Glu Lys Thr Ile Pro
65                  70                  75                  80  
Tyr Ser Asp Lys Leu Phe Glu Met Val Leu Gly Pro Ala Ala Tyr Asn
                85                  90                  95      
Val Pro Leu Pro Lys Lys Ser Ile Gln Ser Gly Pro Leu Lys Ile Ser
            100                 105                 110         
Ser Val Ser Glu Val Met Lys Glu Ser Lys Gln Ser Ala Ser Gln Leu
        115                 120                 125             
Gln Lys Gln Lys Gly Asp Thr Pro Ala Ser Ala Thr Ala Pro Thr Glu
    130                 135                 140                 
Ala Ala Gln Ile Ile Ser Ala Ala Gly Asp Thr Leu Ser Val Pro Ala
145                 150                 155                 160 
Pro Ala Val Gln Pro Glu Glu Ser Leu Lys Thr Asp His Pro Glu Ile
                165                 170                 175     
Gly Glu Gly Lys Pro Thr Pro Ala Leu Ser Glu Glu Ala Ser Ser Ser
            180                 185                 190         
Ser Ile Arg Glu Arg Pro Pro Glu Glu Val Ala Ala Arg Leu Ala Gln
        195                 200                 205             
Gln Glu Lys Gln Glu Gln Val Lys Ile Glu Ser Leu Ala Lys Ser Leu
    210                 215                 220                 
Glu Asp Ala Leu Arg Gln Thr Ala Ser Val Thr Leu Gln Ala Ile Ala
225                 230                 235                 240 
Ala Gln Asn Ala Ala Val Gln Ala Val Asn Ala His Ser Asn Ile Leu
                245                 250                 255     
Lys Ala Ala Met Asp Asn Ser Glu Ile Ala Gly Glu Lys Lys Ser Ala
            260                 265                 270         
Gln Trp Arg Thr Val Glu Gly Ala Leu Lys Glu Arg Arg Lys Ala Val
        275                 280                 285             
Asp Glu Ala Ala Asp Ala Leu Leu Lys Ala Lys Glu Glu Leu Glu Lys
    290                 295                 300                 
Met Lys Ser Val Ile Glu Asn Ala Lys Lys Lys Glu Val Ala Gly Ala
305                 310                 315                 320 
Lys Pro His Ile Thr Ala Ala Glu Gly Lys Leu His Asn Met Ile Val
                325                 330                 335     
Asp Leu Asp Asn Val Val Lys Lys Val Gln Ala Ala Gln Ser Glu Ala
            340                 345                 350         
Lys Val Val Ser Gln Tyr His Glu Leu Val Val Gln Ala Arg Asp Asp
        355                 360                 365             
Phe Lys Arg Glu Leu Asp Ser Ile Thr Pro Glu Val Leu Pro Gly Trp
    370                 375                 380                 
Lys Gly Met Ser Val Ser Asp Leu Ala Asp Lys Leu Ser Thr Asp Asp
385                 390                 395                 400 
Leu Asn Ser Leu Ile Ala His Ala His Arg Arg Ile Asp Gln Leu Asn
                405                 410                 415     
Arg Glu Leu Ala Glu Gln Lys Ala Thr Glu Lys Gln His Ile Thr Leu
            420                 425                 430         
Ala Leu Glu Lys Gln Lys Leu Glu Glu Lys Arg Ala Phe Asp Ser Ala
        435                 440                 445             
Val Ala Lys Ala Leu Glu His His Arg Ser Glu Ile Gln Ala Glu Gln
    450                 455                 460                 
Asp Arg Lys Ile Glu Glu Val Arg Asp Ala Met Glu Asn Glu Met Arg
465                 470                 475                 480 
Thr Gln Leu Arg Arg Gln Ala Ala Ala His Thr Asp His Leu Arg Asp
                485                 490                 495     
Val Leu Arg Val Gln Glu Gln Glu Leu Lys Ser Glu Phe Glu Gln Asn
            500                 505                 510         
Leu Ser Glu Lys Leu Ser Glu Gln Glu Leu Gln Phe Arg Arg Leu Ser
        515                 520                 525             
Gln Glu Gln Val Asp Asn Phe Thr Leu Asp Ile Asn Thr Ala Tyr Ala
    530                 535                 540                 
Arg Leu Arg Gly Ile Glu Gln Ala Val Gln Ser His Ala Val Ala Glu
545                 550                 555                 560 
Glu Glu Ala Arg Lys Ala His Gln Leu Trp Leu Ser Val Glu Ala Leu
                565                 570                 575     
Lys Tyr Ser Met Lys Thr Ser Ser Ala Glu Thr Pro Thr Ile Pro Leu
            580                 585                 590         
Gly Ser Ala Val Glu Ala Ile Lys Ala Asn Cys Ser Asp Asn Glu Phe
        595                 600                 605             
Thr Gln Ala Leu Thr Ala Ala Ile Pro Pro Glu Ser Leu Thr Arg Gly
    610                 615                 620                 
Val Tyr Ser Glu Glu Thr Leu Arg Ala Arg Phe Tyr Ala Val Gln Lys
625                 630                 635                 640 
Leu Ala Arg Arg Val Ala Met Ile Asp Glu Thr Arg Asn Ser Leu Tyr
                645                 650                 655     
Gln Tyr Phe Leu Ser Tyr Leu Gln Ser Leu Leu Leu Phe Pro Pro Gln
            660                 665                 670         
Gln Leu Lys Pro Pro Pro Glu Leu Cys Pro Glu Asp Ile Asn Thr Phe
        675                 680                 685             
Lys Leu Leu Ser Tyr Ala Ser Tyr Cys Ile Glu His Gly Asp Leu Glu
    690                 695                 700                 
Leu Ala Ala Lys Phe Val Asn Gln Leu Lys Gly Glu Ser Arg Arg Val
705                 710                 715                 720 
Ala Gln Asp Trp Leu Lys Glu Ala Arg Met Thr Leu Glu Thr Lys Gln
                725                 730                 735     
Ile Val Glu Ile Leu Thr Ala Tyr Ala Ser Ala Val Gly Ile Gly Thr
            740                 745                 750         
Thr Gln Val Gln Pro Glu
        755             


<210> 716
<211> 201
<212> PRT
<213> Homo sapiens

<400> 716
Met Ala Arg Asp Tyr Asp His Leu Phe Lys Leu Leu Ile Ile Gly Asp
 1               5                  10                  15      
Ser Gly Val Gly Lys Ser Ser Leu Leu Leu Arg Phe Ala Asp Asn Thr
            20                  25                  30          
Phe Ser Gly Ser Tyr Ile Thr Thr Ile Gly Val Asp Phe Lys Ile Arg
        35                  40                  45              
Thr Val Glu Ile Asn Gly Glu Lys Val Lys Leu Gln Ile Trp Asp Thr
    50                  55                  60                  
Ala Gly Gln Glu Arg Phe Arg Thr Ile Thr Ser Thr Tyr Tyr Arg Gly
65                  70                  75                  80  
Thr His Gly Val Ile Val Val Tyr Asp Val Thr Ser Ala Glu Ser Phe
                85                  90                  95      
Val Asn Val Lys Arg Trp Leu His Glu Ile Asn Gln Asn Cys Asp Asp
            100                 105                 110         
Val Cys Arg Ile Leu Val Gly Asn Lys Asn Asp Asp Pro Glu Arg Lys
        115                 120                 125             
Val Val Glu Thr Glu Asp Ala Tyr Lys Phe Ala Gly Gln Met Gly Ile
    130                 135                 140                 
Gln Leu Phe Glu Thr Ser Ala Lys Glu Asn Val Asn Val Glu Glu Met
145                 150                 155                 160 
Phe Asn Cys Ile Thr Glu Leu Val Leu Arg Ala Lys Lys Asp Asn Leu
                165                 170                 175     
Ala Lys Gln Gln Gln Gln Gln Gln Asn Asp Val Val Lys Leu Thr Lys
            180                 185                 190         
Asn Ser Lys Arg Lys Lys Arg Cys Cys
        195                 200     


<210> 717
<211> 201
<212> PRT
<213> Homo sapiens

<400> 717
Met Val Thr Leu Ala Glu Leu Leu Val Leu Leu Ala Ala Leu Leu Ala
 1               5                  10                  15      
Thr Val Ser Gly Tyr Phe Val Ser Ile Asp Ala His Ala Glu Glu Cys
            20                  25                  30          
Phe Phe Glu Arg Val Thr Ser Gly Thr Lys Met Gly Leu Ile Phe Glu
        35                  40                  45              
Val Ala Glu Gly Gly Phe Leu Asp Ile Asp Val Glu Ile Thr Gly Pro
    50                  55                  60                  
Asp Asn Lys Gly Ile Tyr Lys Gly Asp Arg Glu Ser Ser Gly Lys Tyr
65                  70                  75                  80  
Thr Phe Ala Ala His Met Asp Gly Thr Tyr Lys Phe Cys Phe Ser Asn
                85                  90                  95      
Arg Met Ser Thr Met Thr Pro Lys Ile Val Met Phe Thr Ile Asp Ile
            100                 105                 110         
Gly Glu Ala Pro Lys Gly Gln Asp Met Glu Thr Glu Ala His Gln Asn
        115                 120                 125             
Lys Leu Glu Glu Met Ile Asn Glu Leu Ala Val Ala Met Thr Ala Val
    130                 135                 140                 
Lys His Glu Gln Glu Tyr Met Glu Val Arg Glu Arg Ile His Arg Ala
145                 150                 155                 160 
Ile Asn Asp Asn Thr Asn Ser Arg Val Val Leu Trp Ser Phe Phe Glu
                165                 170                 175     
Ala Leu Val Leu Val Ala Met Thr Leu Gly Gln Ile Tyr Tyr Leu Lys
            180                 185                 190         
Arg Phe Phe Glu Val Arg Arg Val Val
        195                 200     


<210> 718
<211> 208
<212> PRT
<213> Homo sapiens

<400> 718
Met Lys Lys Asn Glu Val Tyr Glu Thr Phe Ser Tyr Pro Glu Ser Tyr
 1               5                  10                  15      
Ser Pro Thr Leu Pro Val Ser Arg Arg Glu Asn Asn Ser Pro Ser Asn
            20                  25                  30          
Leu Pro Arg Pro Ser Phe Cys Met Glu Glu Tyr Gln Arg Ala Glu Leu
        35                  40                  45              
Glu Glu Asp Pro Ile Leu Ser Arg Thr Pro Ser Pro Val His Pro Ser
    50                  55                  60                  
Asp Phe Ser Glu His Asn Cys Gln Pro Tyr Tyr Ala Ser Asp Gly Ala
65                  70                  75                  80  
Thr Tyr Gly Ser Ser Ser Gly Leu Cys Leu Gly Asn Pro Arg Ala Asp
                85                  90                  95      
Ser Ile His Asn Thr Tyr Ser Thr Asp His Ala Ser Ala Ala Pro Pro
            100                 105                 110         
Ser Val Thr Arg Ser Pro Val Glu Asn Asp Gly Tyr Ile Glu Glu Gly
        115                 120                 125             
Ser Ile Thr Lys His Pro Ser Thr Trp Ser Val Glu Ala Val Val Leu
    130                 135                 140                 
Phe Leu Lys Gln Thr Asp Pro Leu Ala Leu Cys Pro Leu Val Asp Leu
145                 150                 155                 160 
Phe Arg Ser His Glu Ile Asp Gly Lys Ala Leu Leu Leu Leu Thr Ser
                165                 170                 175     
Asp Val Leu Leu Lys His Leu Gly Val Lys Leu Gly Thr Ala Val Lys
            180                 185                 190         
Leu Cys Tyr Tyr Ile Asp Arg Leu Lys Gln Gly Lys Cys Phe Glu Asn
        195                 200                 205             


<210> 719
<211> 219
<212> PRT
<213> Homo sapiens

<400> 719
Met Ser Gly Leu Ser Gly Pro Pro Ala Arg Arg Gly Pro Phe Pro Leu
 1               5                  10                  15      
Ala Leu Leu Leu Leu Phe Leu Leu Gly Pro Arg Leu Val Leu Ala Ile
            20                  25                  30          
Ser Phe His Leu Pro Ile Asn Ser Arg Lys Cys Leu Arg Glu Glu Ile
        35                  40                  45              
His Lys Asp Leu Leu Val Thr Gly Ala Tyr Glu Ile Ser Asp Gln Ser
    50                  55                  60                  
Gly Gly Ala Gly Gly Leu Arg Ser His Leu Lys Ile Thr Asp Ser Ala
65                  70                  75                  80  
Gly His Ile Leu Tyr Ser Lys Glu Asp Ala Thr Lys Gly Lys Phe Ala
                85                  90                  95      
Phe Thr Thr Glu Asp Tyr Asp Met Phe Glu Val Cys Phe Glu Ser Lys
            100                 105                 110         
Gly Thr Gly Arg Ile Pro Asp Gln Leu Val Ile Leu Asp Met Lys His
        115                 120                 125             
Gly Val Glu Ala Lys Asn Tyr Glu Glu Ile Ala Lys Val Glu Lys Leu
    130                 135                 140                 
Lys Pro Leu Glu Val Glu Leu Arg Arg Leu Glu Asp Leu Ser Glu Ser
145                 150                 155                 160 
Ile Val Asn Asp Phe Ala Tyr Met Lys Lys Arg Glu Glu Glu Met Arg
                165                 170                 175     
Asp Thr Asn Glu Ser Thr Asn Thr Arg Val Leu Tyr Phe Ser Ile Phe
            180                 185                 190         
Ser Met Phe Cys Leu Ile Gly Leu Ala Thr Trp Gln Val Phe Tyr Leu
        195                 200                 205             
Arg Arg Phe Phe Lys Ala Lys Lys Leu Ile Glu
    210                 215                 


<210> 720
<211> 240
<212> PRT
<213> Homo sapiens

<400> 720
Met Ala Glu Tyr Leu Ala Ser Ile Phe Gly Thr Glu Lys Asp Lys Val
 1               5                  10                  15      
Asn Cys Ser Phe Tyr Phe Lys Ile Gly Ala Cys Arg His Gly Asp Arg
            20                  25                  30          
Cys Ser Arg Leu His Asn Lys Pro Thr Phe Ser Gln Thr Ile Ala Leu
        35                  40                  45              
Leu Asn Ile Tyr Arg Asn Pro Gln Asn Ser Ser Gln Ser Ala Asp Gly
    50                  55                  60                  
Leu Arg Cys Ala Val Ser Asp Val Glu Met Gln Glu His Tyr Asp Glu
65                  70                  75                  80  
Phe Phe Glu Glu Val Phe Thr Glu Met Glu Glu Lys Tyr Gly Glu Val
                85                  90                  95      
Glu Glu Met Asn Val Cys Asp Asn Leu Gly Asp His Leu Val Gly Asn
            100                 105                 110         
Val Tyr Val Lys Phe Arg Arg Glu Glu Asp Ala Glu Lys Ala Val Ile
        115                 120                 125             
Asp Leu Asn Asn Arg Trp Phe Asn Gly Gln Pro Ile His Ala Glu Leu
    130                 135                 140                 
Ser Pro Val Thr Asp Phe Arg Glu Ala Cys Cys Arg Gln Tyr Glu Met
145                 150                 155                 160 
Gly Glu Cys Thr Arg Gly Gly Phe Cys Asn Phe Met His Leu Lys Pro
                165                 170                 175     
Ile Ser Arg Glu Leu Arg Arg Glu Leu Tyr Gly Arg Arg Arg Lys Lys
            180                 185                 190         
His Arg Ser Arg Ser Arg Ser Arg Glu Arg Arg Ser Arg Ser Arg Asp
        195                 200                 205             
Arg Gly Arg Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Arg
    210                 215                 220                 
Glu Arg Asp Arg Arg Arg Ser Arg Asp Arg Glu Arg Ser Gly Arg Phe
225                 230                 235                 240 


<210> 721
<211> 76
<212> PRT
<213> Homo sapiens

<400> 721
Met Gln Leu Phe Val Lys Thr Leu Thr Gly Lys Thr Leu Thr Val Glu
 1               5                  10                  15      
Leu Glu Pro Ser Asp Thr Val Glu Asn Leu Lys Ala Lys Ile Gln Asp
            20                  25                  30          
Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys
        35                  40                  45              
Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Leu Gln Lys Glu
    50                  55                  60                  
Ser Thr Ile His Leu Val Leu Arg Leu Arg Gly Gly
65                  70                  75      


<210> 722
<211> 808
<212> PRT
<213> Homo sapiens

<400> 722
Gly Asn Pro Glu Glu Phe Gln Pro Phe Thr Phe Ser Leu Lys Gly Leu
 1               5                  10                  15      
Ser Glu Glu Val Ser His Pro Ala Asp Phe Lys Lys Gly Gly Asn Gln
            20                  25                  30          
Glu Ile Gly Pro Leu Pro Pro Thr Gly Asn Leu Lys Ala Gln Val Met
        35                  40                  45              
Gly Asp Ile Leu Asp Lys Leu Ser Glu Glu Thr Gly His Pro Asn Ser
    50                  55                  60                  
Ser Gln Val Leu Gln Ser Ile Thr Glu Pro Ser Lys Ile Ala Pro Ser
65                  70                  75                  80  
Asp Leu Leu Val Glu Gln Lys Lys Thr Glu Lys Ala Leu His Ser Asp
                85                  90                  95      
Gln Thr Val Lys Leu Pro Asp Val Ser Thr Ser Ser Glu Asp Lys Gln
            100                 105                 110         
Asp Leu Gly Ile Lys Gln Phe Ser Leu Met Arg Glu Asn Leu Pro Leu
        115                 120                 125             
Glu Gln Ser Lys Ser Phe Met Thr Thr Lys Pro Ala Asp Val Lys Glu
    130                 135                 140                 
Thr Lys Met Glu Glu Phe Phe Ile Ser Pro Lys Asp Glu Asn Trp Met
145                 150                 155                 160 
Leu Gly Lys Pro Glu Asn Val Ala Ser Gln His Glu Gln Arg Ile Ala
                165                 170                 175     
Gly Ser Val Gln Leu Asp Ser Ser Ser Ser Asn Glu Leu Arg Pro Gly
            180                 185                 190         
Gln Leu Lys Ala Ala Val Ser Ser Lys Asp His Thr Cys Glu Val Arg
        195                 200                 205             
Lys Gln Val Leu Pro His Ser Ala Glu Glu Ser His Leu Ser Ser Gln
    210                 215                 220                 
Glu Ala Val Ser Ala Leu Asp Thr Ser Ser Gly Asn Thr Glu Thr Leu
225                 230                 235                 240 
Ser Ser Lys Ser Tyr Ser Ser Glu Glu Val Lys Leu Ala Glu Glu Pro
                245                 250                 255     
Lys Ser Leu Val Leu Ala Gly Asn Val Glu Arg Asn Ile Ala Glu Gly
            260                 265                 270         
Lys Glu Ile His Ser Leu Met Glu Ser Glu Ser Leu Leu Leu Glu Lys
        275                 280                 285             
Ala Asn Thr Glu Leu Ser Trp Pro Ser Lys Glu Asp Ser Gln Glu Lys
    290                 295                 300                 
Ile Lys Leu Pro Pro Glu Arg Phe Phe Gln Lys Pro Val Ser Gly Leu
305                 310                 315                 320 
Ser Val Glu Gln Val Lys Ser Glu Thr Ile Ser Ser Ser Val Lys Thr
                325                 330                 335     
Ala His Phe Pro Ala Glu Gly Val Glu Pro Ala Leu Gly Asn Glu Lys
            340                 345                 350         
Glu Ala His Arg Ser Thr Pro Pro Phe Pro Glu Glu Lys Pro Leu Glu
        355                 360                 365             
Glu Ser Lys Met Val Gln Ser Lys Val Ile Asp Asp Ala Asp Glu Gly
    370                 375                 380                 
Lys Lys Pro Ser Pro Glu Val Lys Ile Pro Thr Gln Arg Lys Pro Ile
385                 390                 395                 400 
Ser Ser Ile His Ala Arg Glu Pro Gln Ser Pro Glu Ala Pro Glu Val
                405                 410                 415     
Thr Gln Asn Pro Pro Thr Gln Pro Lys Val Ala Lys Pro Asp Leu Pro
            420                 425                 430         
Glu Glu Lys Gly Lys Lys Gly Ile Ser Ser Phe Lys Ser Trp Met Ser
        435                 440                 445             
Ser Leu Phe Phe Gly Ser Ser Thr Pro Asp Asn Lys Val Ala Glu Gln
    450                 455                 460                 
Glu Asp Leu Glu Thr Gln Pro Ser Pro Ser Val Glu Lys Ala Val Thr
465                 470                 475                 480 
Val Ile Asp Pro Glu Gly Thr Ile Pro Thr Asn Phe Asn Val Ala Glu
                485                 490                 495     
Lys Pro Ala Asp His Ser Leu Ser Glu Val Lys Leu Lys Thr Ala Asp
            500                 505                 510         
Glu Pro Arg Gly Thr Leu Val Lys Ser Gly Asp Gly Gln Asn Val Lys
        515                 520                 525             
Glu Lys Ser Met Ile Leu Ser Asn Val Glu Asp Leu Gln Gln Pro Lys
    530                 535                 540                 
Phe Ile Ser Glu Val Ser Arg Glu Asp Tyr Gly Lys Lys Glu Ile Ser
545                 550                 555                 560 
Gly Asp Ser Glu Glu Met Asn Ile Asn Ser Val Val Thr Ser Ala Asp
                565                 570                 575     
Gly Glu Asn Leu Glu Ile Gln Ser Tyr Ser Leu Ile Gly Glu Lys Leu
            580                 585                 590         
Val Met Glu Glu Ala Lys Thr Ile Val Pro Pro His Val Thr Asp Ser
        595                 600                 605             
Lys Arg Val Gln Lys Pro Ala Ile Ala Pro Pro Ser Lys Trp Asn Ile
    610                 615                 620                 
Ser Ile Phe Lys Glu Glu Pro Arg Ser Asp Gln Lys Gln Lys Ser Leu
625                 630                 635                 640 
Leu Ser Phe Asp Val Val Asp Lys Val Pro Gln Gln Pro Lys Ser Ala
                645                 650                 655     
Ser Ser Asn Phe Ala Ser Lys Asn Ile Thr Lys Glu Ser Glu Lys Pro
            660                 665                 670         
Glu Ser Ile Ile Leu Pro Val Glu Glu Ser Lys Gly Ser Leu Ile Asp
        675                 680                 685             
Phe Ser Glu Asp Arg Leu Lys Lys Glu Met Gln Asn Pro Thr Ser Leu
    690                 695                 700                 
Lys Ile Ser Glu Glu Glu Thr Lys Leu Arg Ser Val Ser Pro Thr Glu
705                 710                 715                 720 
Lys Lys Asp Asn Leu Glu Asn Arg Ser Tyr Thr Leu Ala Glu Lys Lys
                725                 730                 735     
Val Leu Ala Glu Lys Gln Asn Ser Val Ala Pro Leu Glu Leu Arg Asp
            740                 745                 750         
Ser Asn Glu Ile Gly Lys Thr Gln Ile Thr Leu Gly Ser Arg Ser Thr
        755                 760                 765             
Glu Leu Lys Glu Ser Lys Ala Asp Ala Met Pro Gln His Phe Tyr Gln
    770                 775                 780                 
Asn Glu Asp Tyr Asn Glu Arg Pro Lys Ile Ile Val Gly Ser Glu Lys
785                 790                 795                 800 
Glu Lys Asp Glu Lys Lys Lys Lys
                805             


<210> 723
<211> 51
<212> PRT
<213> Homo sapiens

<400> 723
Met Val Ala Tyr Trp Arg Gln Ala Gly Leu Ser Tyr Ile Arg Tyr Ser
 1               5                  10                  15      
Gln Ile Cys Ala Lys Ala Val Arg Asp Ala Leu Lys Thr Glu Phe Lys
            20                  25                  30          
Ala Asn Ala Glu Lys Thr Ser Gly Ser Asn Val Lys Ile Val Lys Val
        35                  40                  45              
Lys Lys Glu
    50      


<210> 724
<211> 227
<212> PRT
<213> Homo sapiens

<400> 724
Met Ser Val Val Pro Pro Asn Arg Ser Gln Thr Gly Trp Pro Arg Gly
 1               5                  10                  15      
Val Thr Gln Phe Gly Asn Lys Tyr Ile Gln Gln Thr Lys Pro Leu Thr
            20                  25                  30          
Leu Glu Arg Thr Ile Asn Leu Tyr Pro Leu Thr Asn Tyr Thr Phe Gly
        35                  40                  45              
Thr Lys Glu Pro Leu Tyr Glu Lys Asp Ser Ser Val Ala Ala Arg Phe
    50                  55                  60                  
Gln Arg Met Arg Glu Glu Phe Asp Lys Ile Gly Met Arg Arg Thr Val
65                  70                  75                  80  
Glu Gly Val Leu Ile Val His Glu His Arg Leu Pro His Val Leu Leu
                85                  90                  95      
Leu Gln Leu Gly Thr Thr Phe Phe Lys Leu Pro Gly Gly Glu Leu Asn
            100                 105                 110         
Pro Gly Glu Asp Glu Val Glu Gly Leu Lys Arg Leu Met Thr Glu Ile
        115                 120                 125             
Leu Gly Arg Gln Asp Gly Val Leu Gln Asp Trp Val Ile Asp Asp Cys
    130                 135                 140                 
Ile Gly Asn Trp Trp Arg Pro Asn Phe Glu Pro Pro Gln Tyr Pro Tyr
145                 150                 155                 160 
Ile Pro Ala His Ile Thr Lys Pro Lys Glu His Lys Lys Leu Phe Leu
                165                 170                 175     
Val Gln Leu Gln Glu Lys Ala Leu Phe Ala Val Pro Lys Asn Tyr Lys
            180                 185                 190         
Leu Val Ala Ala Pro Leu Phe Glu Leu Tyr Asp Asn Ala Pro Gly Tyr
        195                 200                 205             
Gly Pro Ile Ile Ser Ser Leu Pro Gln Leu Leu Ser Arg Phe Asn Phe
    210                 215                 220                 
Ile Tyr Asn
225         


<210> 725
<211> 385
<212> PRT
<213> Homo sapiens

<400> 725
Met Ala Val Leu Ser Gly Val Arg Trp Leu Thr Arg Ala Leu Val Ser
 1               5                  10                  15      
Ala Gly Asn Pro Gly Ala Trp Arg Gly Leu Ser Thr Ser Ala Ala Ala
            20                  25                  30          
His Ala Ala Ser Arg Ser Gln Ala Glu Asp Val Arg Val Glu Gly Ser
        35                  40                  45              
Phe Pro Val Thr Met Leu Pro Gly Asp Gly Val Gly Pro Glu Leu Met
    50                  55                  60                  
His Ala Val Lys Glu Val Phe Lys Ala Ala Ala Val Pro Val Glu Phe
65                  70                  75                  80  
Gln Glu His His Leu Ser Glu Val Gln Asn Met Ala Ser Glu Glu Lys
                85                  90                  95      
Leu Glu Gln Val Leu Ser Ser Met Lys Glu Asn Lys Val Ala Ile Ile
            100                 105                 110         
Gly Lys Ile His Thr Pro Met Glu Tyr Lys Gly Glu Leu Ala Ser Tyr
        115                 120                 125             
Asp Met Arg Leu Arg Arg Lys Leu Asp Leu Phe Ala Asn Val Val His
    130                 135                 140                 
Val Lys Ser Leu Pro Gly Tyr Met Thr Arg His Asn Asn Leu Asp Leu
145                 150                 155                 160 
Val Ile Ile Arg Glu Gln Thr Glu Gly Glu Tyr Ser Ser Leu Glu His
                165                 170                 175     
Glu Ser Ala Arg Gly Val Ile Glu Cys Leu Lys Ile Val Thr Arg Ala
            180                 185                 190         
Lys Ser Gln Arg Ile Ala Lys Phe Ala Phe Asp Tyr Ala Thr Lys Lys
        195                 200                 205             
Gly Arg Gly Lys Val Thr Ala Val His Lys Ala Asn Ile Met Lys Leu
    210                 215                 220                 
Gly Asp Gly Leu Phe Leu Gln Cys Cys Glu Glu Val Ala Glu Leu Tyr
225                 230                 235                 240 
Pro Lys Ile Lys Phe Glu Thr Met Ile Ile Asp Asn Cys Cys Met Gln
                245                 250                 255     
Leu Val Gln Asn Pro Tyr Gln Phe Asp Val Leu Val Met Pro Asn Leu
            260                 265                 270         
Tyr Gly Asn Ile Ile Asp Asn Leu Ala Ala Gly Leu Val Gly Gly Ala
        275                 280                 285             
Gly Val Val Pro Gly Glu Ser Tyr Ser Ala Glu Tyr Ala Val Phe Glu
    290                 295                 300                 
Thr Gly Ala Arg His Pro Phe Ala Gln Ala Val Gly Arg Asn Ile Ala
305                 310                 315                 320 
Asn Pro Thr Ala Met Leu Leu Ser Ala Ser Asn Met Leu Arg His Leu
                325                 330                 335     
Asn Leu Glu Tyr His Ser Ser Met Ile Ala Asp Ala Val Lys Lys Val
            340                 345                 350         
Ile Lys Val Gly Lys Val Arg Thr Arg Asp Met Gly Gly Tyr Ser Thr
        355                 360                 365             
Thr Thr Asp Phe Ile Lys Ser Val Ile Gly His Leu Gln Thr Lys Gly
    370                 375                 380                 
Ser
385 


<210> 726
<211> 233
<212> PRT
<213> Homo sapiens

<400> 726
Met Ala Leu Pro Gly Ser Ser Gln Asp Gln Ala Trp Ser Leu Glu Pro
 1               5                  10                  15      
Pro Ala Ala Thr Ala Ala Ala Ser Ser Ser Ser Gly Pro Gln Glu Arg
            20                  25                  30          
Glu Gly Ala Gly Ser Pro Ala Ala Pro Gly Thr Leu Pro Leu Glu Lys
        35                  40                  45              
Val Lys Arg Pro Met Asn Ala Phe Met Val Trp Ser Ser Ala Gln Arg
    50                  55                  60                  
Arg Gln Met Ala Gln Gln Asn Pro Lys Met His Asn Ser Glu Ile Ser
65                  70                  75                  80  
Lys Arg Leu Gly Ala Gln Trp Lys Leu Leu Asp Glu Asp Glu Lys Arg
                85                  90                  95      
Pro Phe Val Glu Glu Ala Lys Arg Leu Arg Ala Arg His Leu Arg Asp
            100                 105                 110         
Tyr Pro Asp Tyr Lys Tyr Arg Pro Arg Arg Lys Ala Lys Ser Ser Gly
        115                 120                 125             
Ala Gly Pro Ser Arg Cys Gly Gln Gly Arg Gly Asn Leu Ala Ser Gly
    130                 135                 140                 
Gly Pro Leu Trp Gly Pro Gly Tyr Ala Thr Thr Gln Pro Ser Arg Gly
145                 150                 155                 160 
Phe Gly Tyr Arg Pro Pro Ser Tyr Ser Thr Ala Tyr Leu Pro Gly Ser
                165                 170                 175     
Tyr Gly Ser Ser His Cys Lys Leu Glu Ala Pro Ser Pro Cys Ser Leu
            180                 185                 190         
Pro Gln Ser Asp Pro Arg Leu Gln Gly Glu Leu Leu Pro Thr Tyr Thr
        195                 200                 205             
His Tyr Leu Pro Pro Gly Ser Pro Thr Pro Tyr Asn Pro Pro Leu Ala
    210                 215                 220                 
Gly Ala Pro Met Pro Leu Thr His Leu
225                 230             


<210> 727
<211> 315
<212> PRT
<213> Homo sapiens

<400> 727
Met Val Gln Gln Arg Gly Ala Arg Ala Lys Arg Asp Gly Gly Pro Pro
 1               5                  10                  15      
Pro Pro Gly Pro Gly Pro Ala Glu Glu Gly Ala Arg Glu Pro Gly Trp
            20                  25                  30          
Cys Lys Thr Pro Ser Gly His Ile Lys Arg Pro Met Asn Ala Phe Met
        35                  40                  45              
Val Trp Ser Gln His Glu Arg Arg Lys Ile Met Asp Gln Trp Pro Asp
    50                  55                  60                  
Met His Asn Ala Glu Ile Ser Lys Arg Leu Gly Arg Arg Trp Gln Leu
65                  70                  75                  80  
Leu Gln Asp Ser Glu Lys Ile Pro Phe Val Arg Glu Ala Glu Arg Leu
                85                  90                  95      
Arg Leu Lys His Met Ala Asp Tyr Pro Asp Tyr Lys Tyr Arg Pro Arg
            100                 105                 110         
Lys Lys Ser Lys Gly Ala Pro Ala Lys Ala Arg Pro Arg Pro Pro Gly
        115                 120                 125             
Gly Ser Gly Gly Gly Ser Gly Ser Ser Pro Gly Arg Ser Cys Leu Ala
    130                 135                 140                 
Ala Gly Ala Ala Glu Gln Arg Glu Gly Leu Trp Gly Ala Gly Arg Arg
145                 150                 155                 160 
Arg Pro Arg Thr Thr Met Lys Thr Thr Thr Arg Ser Cys Trp Lys Cys
                165                 170                 175     
Ala Trp Ser Arg Pro Arg Gly Gly Ser Cys Gly Gly Trp Ser Arg Arg
            180                 185                 190         
Asp Gly Pro Leu Gly Asp Lys Arg Ser Arg Ala Gln Gly Pro Ser Gly
        195                 200                 205             
Glu Gly Ala Ala Ala Ala Ala Ala Ala Ser Pro Thr Pro Ser Glu Asp
    210                 215                 220                 
Glu Glu Pro Glu Glu Glu Glu Glu Glu Ala Ala Ala Ala Glu Glu Gly
225                 230                 235                 240 
Glu Glu Glu Thr Val Ala Ser Gly Glu Glu Ser Leu Gly Phe Leu Ser
                245                 250                 255     
Arg Leu Pro Pro Gly Pro Ala Gly Leu Asp Cys Ser Ala Leu Asp Arg
            260                 265                 270         
Asp Pro Asp Leu Gln Pro Pro Ser Gly Thr Ser His Phe Glu Phe Pro
        275                 280                 285             
Asp Tyr Cys Thr Pro Glu Val Thr Glu Met Ile Ala Gly Asp Trp Arg
    290                 295                 300                 
Pro Ser Ser Ile Ala Asp Leu Val Phe Thr Tyr
305                 310                 315 


<210> 728
<211> 1167
<212> PRT
<213> Homo sapiens

<400> 728
Met Glu Glu Leu Ile Trp Glu Gln Tyr Thr Val Thr Leu Gln Lys Asp
 1               5                  10                  15      
Ser Lys Arg Gly Phe Gly Ile Ala Val Ser Gly Gly Arg Asp Asn Pro
            20                  25                  30          
His Phe Glu Asn Gly Glu Thr Ser Ile Val Ile Ser Asp Val Leu Pro
        35                  40                  45              
Gly Gly Pro Ala Asp Gly Leu Leu Gln Glu Asn Asp Arg Val Val Met
    50                  55                  60                  
Val Asn Gly Thr Pro Met Glu Asp Val Leu His Ser Phe Ala Val Gln
65                  70                  75                  80  
Gln Leu Arg Lys Ser Gly Lys Val Ala Ala Ile Val Val Lys Arg Pro
                85                  90                  95      
Arg Lys Val Gln Val Ala Ala Leu Gln Ala Ser Pro Pro Leu Asp Gln
            100                 105                 110         
Asp Asp Arg Ala Phe Glu Val Met Asp Glu Phe Asp Gly Arg Ser Phe
        115                 120                 125             
Arg Ser Gly Tyr Ser Glu Arg Ser Arg Leu Asn Ser His Gly Gly Arg
    130                 135                 140                 
Ser Arg Ser Trp Glu Asp Ser Pro Glu Arg Gly Arg Pro His Glu Arg
145                 150                 155                 160 
Ala Arg Ser Arg Glu Arg Asp Leu Ser Arg Asp Arg Ser Arg Gly Arg
                165                 170                 175     
Ser Leu Glu Arg Gly Leu Asp Gln Asp His Ala Arg Thr Arg Asp Arg
            180                 185                 190         
Ser Arg Gly Arg Ser Leu Glu Arg Gly Leu Asp His Asp Phe Gly Pro
        195                 200                 205             
Ser Arg Asp Arg Asp Arg Asp Arg Ser Arg Gly Arg Ser Ile Asp Gln
    210                 215                 220                 
Asp Tyr Glu Arg Ala Tyr His Arg Ala Tyr Asp Pro Asp Tyr Glu Arg
225                 230                 235                 240 
Ala Tyr Ser Pro Glu Tyr Arg Arg Gly Ala Arg His Asp Ala Arg Ser
                245                 250                 255     
Arg Gly Pro Arg Ser Arg Ser Arg Glu His Pro His Ser Arg Ser Pro
            260                 265                 270         
Ser Pro Glu Pro Arg Gly Arg Pro Gly Pro Ile Gly Val Leu Leu Met
        275                 280                 285             
Lys Ser Arg Ala Asn Glu Glu Tyr Gly Leu Arg Leu Gly Ser Gln Ile
    290                 295                 300                 
Phe Val Lys Glu Met Thr Arg Thr Gly Leu Ala Thr Lys Asp Gly Asn
305                 310                 315                 320 
Leu His Glu Gly Asp Ile Ile Leu Lys Ile Asn Gly Thr Val Thr Glu
                325                 330                 335     
Asn Met Ser Leu Thr Asp Ala Arg Lys Leu Ile Glu Lys Ser Arg Gly
            340                 345                 350         
Lys Leu Gln Leu Val Val Leu Arg Asp Ser Gln Gln Thr Leu Ile Asn
        355                 360                 365             
Ile Pro Ser Leu Asn Asp Ser Asp Ser Glu Ile Glu Asp Ile Ser Glu
    370                 375                 380                 
Ile Glu Ser Asn Arg Ser Phe Ser Pro Glu Glu Arg Arg His Gln Tyr
385                 390                 395                 400 
Ser Asp Tyr Asp Tyr His Ser Ser Ser Glu Lys Leu Lys Glu Arg Pro
                405                 410                 415     
Ser Ser Arg Glu Asp Thr Pro Ser Arg Leu Ser Arg Met Gly Ala Thr
            420                 425                 430         
Pro Thr Pro Phe Lys Ser Thr Gly Asp Ile Ala Gly Thr Val Val Pro
        435                 440                 445             
Glu Thr Asn Lys Glu Pro Arg Tyr Gln Glu Glu Pro Pro Ala Pro Gln
    450                 455                 460                 
Pro Lys Ala Ala Pro Arg Thr Phe Leu Arg Pro Ser Pro Glu Asp Glu
465                 470                 475                 480 
Ala Ile Tyr Gly Pro Asn Thr Lys Met Val Arg Phe Lys Lys Gly Asp
                485                 490                 495     
Ser Val Gly Leu Arg Leu Ala Gly Gly Asn Asp Val Gly Ile Phe Val
            500                 505                 510         
Ala Gly Ile Gln Glu Gly Thr Ser Ala Glu Gln Glu Gly Leu Gln Glu
        515                 520                 525             
Gly Asp Gln Ile Leu Lys Val Asn Thr Gln Asp Phe Arg Gly Leu Val
    530                 535                 540                 
Arg Glu Asp Ala Val Leu Tyr Leu Leu Glu Ile Pro Lys Gly Glu Met
545                 550                 555                 560 
Val Thr Ile Leu Ala Gln Ser Arg Ala Asp Val Tyr Arg Asp Ile Leu
                565                 570                 575     
Ala Cys Gly Arg Gly Asp Ser Phe Phe Ile Arg Ser His Phe Glu Cys
            580                 585                 590         
Glu Lys Glu Thr Pro Gln Ser Leu Ala Phe Thr Arg Gly Glu Val Phe
        595                 600                 605             
Arg Val Val Asp Thr Leu Tyr Asp Gly Lys Leu Gly Asn Trp Leu Ala
    610                 615                 620                 
Val Arg Ile Gly Asn Glu Leu Glu Lys Gly Leu Ile Pro Asn Lys Ser
625                 630                 635                 640 
Arg Ala Glu Gln Met Ala Ser Val Gln Asn Ala Gln Arg Asp Asn Ala
                645                 650                 655     
Gly Asp Arg Ala Asp Phe Trp Arg Met Arg Gly Gln Arg Ser Gly Val
            660                 665                 670         
Lys Lys Asn Leu Arg Lys Ser Arg Glu Asp Leu Thr Ala Val Val Ser
        675                 680                 685             
Val Ser Thr Lys Phe Pro Ala Tyr Glu Arg Val Leu Leu Arg Glu Ala
    690                 695                 700                 
Gly Phe Lys Arg Pro Val Val Leu Phe Gly Pro Ile Ala Asp Ile Ala
705                 710                 715                 720 
Met Glu Lys Leu Ala Asn Glu Leu Pro Asp Trp Phe Gln Thr Ala Lys
                725                 730                 735     
Thr Glu Pro Lys Asp Ala Gly Ser Glu Lys Ser Thr Gly Val Val Arg
            740                 745                 750         
Leu Asn Thr Val Arg Gln Ile Ile Glu Gln Asp Lys His Ala Leu Leu
        755                 760                 765             
Asp Val Thr Pro Lys Ala Val Asp Leu Leu Asn Tyr Thr Gln Trp Phe
    770                 775                 780                 
Pro Ile Val Ile Phe Phe Asn Pro Asp Ser Arg Gln Gly Val Lys Thr
785                 790                 795                 800 
Met Arg Gln Arg Leu Asn Pro Thr Ser Asn Lys Ser Ser Arg Lys Leu
                805                 810                 815     
Phe Asp Gln Ala Asn Lys Leu Lys Lys Thr Cys Ala His Leu Phe Thr
            820                 825                 830         
Ala Thr Ile Asn Leu Asn Ser Ala Asn Asp Ser Trp Phe Gly Ser Leu
        835                 840                 845             
Lys Asp Thr Ile Gln His Gln Gln Gly Glu Ala Val Trp Val Ser Glu
    850                 855                 860                 
Gly Lys Met Glu Gly Met Asp Asp Asp Pro Glu Asp Arg Met Ser Tyr
865                 870                 875                 880 
Leu Thr Ala Met Gly Ala Asp Tyr Leu Ser Cys Asp Ser Arg Leu Ile
                885                 890                 895     
Ser Asp Phe Glu Asp Thr Asp Gly Glu Gly Gly Ala Tyr Thr Asp Asn
            900                 905                 910         
Glu Leu Asp Glu Pro Ala Glu Glu Pro Leu Val Ser Ser Ile Thr Arg
        915                 920                 925             
Ser Ser Glu Pro Val Gln His Glu Glu Ser Ile Arg Lys Pro Ser Pro
    930                 935                 940                 
Glu Pro Arg Ala Gln Met Arg Arg Ala Ala Ser Ser Asp Gln Leu Arg
945                 950                 955                 960 
Asp Asn Ser Pro Pro Pro Ala Phe Lys Pro Glu Pro Pro Lys Ala Lys
                965                 970                 975     
Thr Gln Asn Lys Glu Glu Ser Tyr Asp Phe Ser Lys Ser Tyr Glu Tyr
            980                 985                 990         
Lys Ser Asn Pro Ser Ala Val Ala Gly Asn Glu Thr Pro Gly Ala Ser
        995                 1000                1005            
Thr Lys Gly Tyr Pro Pro Pro Val Ala Ala Lys Pro Thr Phe Gly Arg
    1010                1015                1020                
Ser Ile Leu Lys Pro Ser Thr Pro Ile Pro Pro Gln Glu Gly Glu Glu
1025                1030                1035                1040
Val Gly Glu Ser Ser Glu Glu Gln Asp Asn Ala Pro Lys Ser Val Leu
                1045                1050                1055    
Gly Lys Val Lys Ile Phe Glu Lys Met Asp His Lys Ala Arg Leu Gln
            1060                1065                1070        
Arg Met Gln Glu Leu Gln Glu Ala Gln Asn Ala Arg Ile Glu Ile Ala
        1075                1080                1085            
Gln Lys His Pro Asp Ile Tyr Ala Val Pro Ile Lys Thr His Lys Pro
    1090                1095                1100                
Asp Pro Gly Thr Pro Gln His Thr Ser Ser Arg Pro Pro Glu Pro Gln
1105                1110                1115                1120
Lys Ala Pro Ser Arg Pro Tyr Gln Asp Thr Arg Gly Ser Tyr Gly Ser
                1125                1130                1135    
Asp Ala Glu Glu Glu Glu Tyr Arg Gln Gln Leu Ser Glu His Ser Lys
            1140                1145                1150        
Arg Gly Tyr Tyr Gly Gln Ser Ala Arg Tyr Arg Asp Thr Glu Leu
        1155                1160                1165        


<210> 729
<211> 69
<212> PRT
<213> Homo sapiens

<400> 729
Met Val Pro Pro Val Gln Val Ser Pro Leu Ile Lys Leu Gly Arg Tyr
 1               5                  10                  15      
Ser Ala Leu Phe Leu Gly Val Ala Tyr Gly Ala Thr Arg Tyr Asn Tyr
            20                  25                  30          
Leu Lys Pro Arg Ala Glu Glu Glu Arg Arg Ile Ala Ala Glu Glu Lys
        35                  40                  45              
Lys Lys Gln Asp Glu Leu Lys Arg Ile Ala Arg Glu Leu Ala Glu Asp
    50                  55                  60                  
Asp Ser Ile Leu Lys
65                  


<210> 730
<211> 515
<212> PRT
<213> Homo sapiens

<400> 730
Met Gly His Asn Gly Ser Trp Ile Ser Pro Asn Ala Ser Glu Pro His
 1               5                  10                  15      
Asn Ala Ser Gly Ala Glu Ala Ala Gly Val Asn Arg Ser Ala Leu Gly
            20                  25                  30          
Glu Phe Gly Glu Ala Gln Leu Tyr Arg Gln Phe Thr Thr Thr Val Gln
        35                  40                  45              
Val Val Ile Phe Ile Gly Ser Leu Leu Gly Asn Phe Met Val Leu Trp
    50                  55                  60                  
Ser Thr Cys Arg Thr Thr Val Phe Lys Ser Val Thr Asn Arg Phe Ile
65                  70                  75                  80  
Lys Asn Leu Ala Cys Ser Gly Ile Cys Ala Ser Leu Val Cys Val Pro
                85                  90                  95      
Phe Asp Ile Ile Leu Ser Thr Ser Pro His Cys Cys Trp Trp Ile Tyr
            100                 105                 110         
Thr Met Leu Phe Cys Lys Val Val Lys Phe Leu His Lys Val Phe Cys
        115                 120                 125             
Ser Val Thr Ile Leu Ser Phe Pro Ala Ile Ala Leu Asp Arg Tyr Tyr
    130                 135                 140                 
Ser Val Leu Tyr Pro Leu Glu Arg Lys Ile Ser Asp Ala Lys Ser Arg
145                 150                 155                 160 
Glu Leu Val Met Tyr Ile Trp Ala His Ala Val Val Ala Ser Val Pro
                165                 170                 175     
Val Phe Ala Val Thr Asn Val Ala Asp Ile Tyr Ala Thr Ser Thr Cys
            180                 185                 190         
Thr Glu Val Trp Ser Asn Ser Leu Gly His Leu Val Tyr Val Leu Val
        195                 200                 205             
Tyr Asn Ile Thr Thr Val Ile Val Pro Val Val Val Val Phe Leu Phe
    210                 215                 220                 
Leu Ile Leu Ile Arg Arg Ala Leu Ser Ala Ser Gln Lys Lys Lys Val
225                 230                 235                 240 
Ile Ile Ala Ala Leu Arg Thr Pro Gln Asn Thr Ile Ser Ile Pro Tyr
                245                 250                 255     
Ala Ser Gln Arg Glu Ala Glu Leu His Ala Thr Leu Leu Ser Met Val
            260                 265                 270         
Met Val Phe Ile Leu Cys Ser Val Pro Tyr Ala Thr Leu Val Val Tyr
        275                 280                 285             
Gln Thr Val Leu Asn Val Pro Asp Thr Ser Val Phe Leu Leu Leu Thr
    290                 295                 300                 
Ala Val Trp Leu Pro Lys Val Ser Leu Leu Ala Asn Pro Val Leu Phe
305                 310                 315                 320 
Leu Thr Val Asn Lys Ser Val Arg Lys Cys Leu Ile Gly Thr Leu Val
                325                 330                 335     
Gln Leu His His Arg Tyr Ser Arg Arg Asn Val Val Ser Thr Gly Ser
            340                 345                 350         
Gly Met Ala Glu Ala Ser Leu Glu Pro Ser Ile Arg Ser Gly Ser Gln
        355                 360                 365             
Leu Leu Glu Met Phe His Ile Gly Gln Gln Gln Ile Phe Lys Pro Thr
    370                 375                 380                 
Glu Asp Glu Glu Glu Ser Glu Ala Lys Tyr Ile Gly Ser Ala Asp Phe
385                 390                 395                 400 
Gln Ala Lys Glu Ile Phe Ser Thr Cys Leu Glu Gly Glu Gln Gly Pro
                405                 410                 415     
Gln Phe Ala Pro Ser Ala Pro Pro Leu Ser Thr Val Asp Ser Val Ser
            420                 425                 430         
Gln Val Ala Pro Ala Ala Pro Val Glu Pro Glu Thr Phe Pro Asp Lys
        435                 440                 445             
Tyr Ser Leu Gln Phe Gly Phe Gly Pro Phe Glu Leu Pro Pro Gln Trp
    450                 455                 460                 
Leu Ser Glu Thr Arg Asn Ser Lys Lys Arg Leu Leu Pro Pro Leu Gly
465                 470                 475                 480 
Asn Thr Pro Glu Glu Leu Ile Gln Thr Lys Val Pro Lys Val Gly Arg
                485                 490                 495     
Val Glu Arg Lys Met Ser Arg Asn Asn Lys Val Ser Ile Phe Pro Lys
            500                 505                 510         
Val Asp Ser
        515 


<210> 731
<211> 3433
<212> PRT
<213> Homo sapiens

<400> 731
Met Ala Lys Tyr Gly Glu His Glu Ala Ser Pro Asp Asn Gly Gln Asn
 1               5                  10                  15      
Glu Phe Ser Asp Ile Ile Lys Ser Arg Ser Asp Glu His Asn Asp Val
            20                  25                  30          
Gln Lys Lys Thr Phe Thr Lys Trp Ile Asn Ala Arg Phe Ser Lys Ser
        35                  40                  45              
Gly Lys Pro Pro Ile Asn Asp Met Phe Thr Asp Leu Lys Asp Gly Arg
    50                  55                  60                  
Lys Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Thr Ser Leu Pro Lys
65                  70                  75                  80  
Glu Arg Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Arg Val
                85                  90                  95      
Leu Gln Val Leu His Gln Asn Asn Val Glu Leu Val Asn Ile Gly Gly
            100                 105                 110         
Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Leu Trp
        115                 120                 125             
Ser Ile Ile Leu His Trp Gln Val Lys Asp Val Met Lys Asp Val Met
    130                 135                 140                 
Ser Asp Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val
145                 150                 155                 160 
Arg Gln Thr Thr Arg Pro Tyr Ser Gln Val Asn Val Leu Asn Phe Thr
                165                 170                 175     
Thr Ser Trp Thr Asp Gly Leu Ala Phe Asn Ala Val Leu His Arg His
            180                 185                 190         
Lys Pro Asp Leu Phe Ser Trp Asp Lys Val Val Lys Met Ser Pro Ile
        195                 200                 205             
Glu Arg Leu Glu His Ala Phe Ser Lys Ala Gln Thr Tyr Leu Gly Ile
    210                 215                 220                 
Glu Lys Leu Leu Asp Pro Glu Asp Val Ala Val Arg Leu Pro Asp Lys
225                 230                 235                 240 
Lys Ser Ile Ile Met Tyr Leu Thr Ser Leu Phe Glu Val Leu Pro Gln
                245                 250                 255     
Gln Val Thr Ile Asp Ala Ile Arg Glu Val Glu Thr Leu Pro Arg Lys
            260                 265                 270         
Tyr Lys Lys Glu Cys Glu Glu Glu Ala Ile Asn Ile Gln Ser Thr Ala
        275                 280                 285             
Pro Glu Glu Glu His Glu Ser Pro Arg Ala Glu Thr Pro Ser Thr Val
    290                 295                 300                 
Thr Glu Val Asp Met Asp Leu Asp Ser Tyr Gln Ile Ala Leu Glu Glu
305                 310                 315                 320 
Val Leu Thr Trp Leu Leu Ser Ala Glu Asp Thr Phe Gln Glu Gln Asp
                325                 330                 335     
Asp Ile Ser Asp Asp Val Glu Glu Val Lys Asp Gln Phe Ala Thr His
            340                 345                 350         
Glu Ala Phe Met Met Glu Leu Thr Ala His Gln Ser Ser Val Gly Ser
        355                 360                 365             
Val Leu Gln Ala Gly Asn Gln Leu Ile Thr Gln Gly Thr Leu Ser Asp
    370                 375                 380                 
Glu Glu Glu Phe Glu Ile Gln Glu Gln Met Thr Leu Leu Asn Ala Arg
385                 390                 395                 400 
Trp Glu Ala Leu Arg Val Glu Ser Met Asp Arg Gln Ser Arg Leu His
                405                 410                 415     
Asp Val Leu Met Glu Leu Gln Lys Lys Gln Leu Gln Gln Leu Ser Ala
            420                 425                 430         
Trp Leu Thr Leu Thr Glu Glu Arg Ile Gln Lys Met Glu Thr Cys Pro
        435                 440                 445             
Leu Asp Asp Asp Val Lys Ser Leu Gln Lys Leu Leu Glu Glu His Lys
    450                 455                 460                 
Ser Leu Gln Ser Asp Leu Glu Ala Glu Gln Val Lys Val Asn Ser Leu
465                 470                 475                 480 
Thr His Met Val Val Ile Val Asp Glu Asn Ser Gly Glu Ser Ala Thr
                485                 490                 495     
Ala Ile Leu Glu Asp Gln Leu Gln Lys Leu Gly Glu Arg Trp Thr Ala
            500                 505                 510         
Val Cys Arg Trp Thr Glu Glu Arg Trp Asn Arg Leu Gln Glu Ile Asn
        515                 520                 525             
Ile Leu Trp Gln Glu Leu Leu Glu Glu Gln Cys Leu Leu Lys Ala Trp
    530                 535                 540                 
Leu Thr Glu Lys Glu Glu Ala Leu Asn Lys Val Gln Thr Ser Asn Phe
545                 550                 555                 560 
Lys Asp Gln Lys Glu Leu Ser Val Ser Val Arg Arg Leu Ala Ile Leu
                565                 570                 575     
Lys Glu Asp Met Glu Met Lys Arg Gln Thr Leu Asp Gln Leu Ser Glu
            580                 585                 590         
Ile Gly Gln Asp Val Gly Gln Leu Leu Asp Asn Ser Lys Ala Ser Lys
        595                 600                 605             
Lys Ile Asn Ser Asp Ser Glu Glu Leu Thr Gln Arg Trp Asp Ser Leu
    610                 615                 620                 
Val Gln Arg Leu Glu Asp Ser Ser Asn Gln Val Thr Gln Ala Val Ala
625                 630                 635                 640 
Lys Leu Gly Met Ser Gln Ile Pro Gln Lys Asp Leu Leu Glu Thr Val
                645                 650                 655     
Arg Val Arg Glu Gln Ala Ile Thr Lys Lys Ser Lys Gln Glu Leu Pro
            660                 665                 670         
Pro Pro Pro Pro Pro Lys Lys Arg Gln Ile His Val Asp Ile Glu Ala
        675                 680                 685             
Lys Lys Lys Phe Asp Ala Ile Ser Ala Glu Leu Leu Asn Trp Ile Leu
    690                 695                 700                 
Lys Trp Lys Thr Ala Ile Gln Thr Thr Glu Ile Lys Glu Tyr Met Lys
705                 710                 715                 720 
Met Gln Asp Thr Ser Glu Met Lys Lys Lys Leu Lys Ala Leu Glu Lys
                725                 730                 735     
Glu Gln Arg Glu Arg Ile Pro Arg Ala Asp Glu Leu Asn Gln Thr Gly
            740                 745                 750         
Gln Ile Leu Val Glu Gln Met Gly Lys Glu Gly Leu Pro Thr Glu Glu
        755                 760                 765             
Ile Lys Asn Val Leu Glu Lys Val Ser Ser Glu Trp Lys Asn Val Ser
    770                 775                 780                 
Gln His Leu Glu Asp Leu Glu Arg Lys Ile Gln Leu Gln Glu Asp Ile
785                 790                 795                 800 
Asn Ala Tyr Phe Lys Gln Leu Asp Glu Leu Glu Lys Val Ile Lys Thr
                805                 810                 815     
Lys Glu Glu Trp Val Lys His Thr Ser Ile Ser Glu Ser Ser Arg Gln
            820                 825                 830         
Ser Leu Pro Ser Leu Lys Asp Ser Cys Gln Arg Glu Leu Thr Asn Leu
        835                 840                 845             
Leu Gly Leu His Pro Lys Ile Glu Met Ala Arg Ala Ser Cys Ser Ala
    850                 855                 860                 
Leu Met Ser Gln Pro Ser Ala Pro Asp Phe Val Gln Arg Gly Phe Asp
865                 870                 875                 880 
Ser Phe Leu Gly Arg Tyr Gln Ala Val Gln Glu Ala Val Glu Asp Arg
                885                 890                 895     
Gln Gln His Leu Glu Asn Glu Leu Lys Gly Gln Pro Gly His Ala Tyr
            900                 905                 910         
Leu Glu Thr Leu Lys Thr Leu Lys Asp Val Leu Asn Asp Ser Glu Asn
        915                 920                 925             
Lys Ala Gln Val Ser Leu Asn Val Leu Asn Asp Leu Ala Lys Val Glu
    930                 935                 940                 
Lys Ala Leu Gln Glu Lys Lys Thr Leu Asp Glu Ile Leu Glu Asn Gln
945                 950                 955                 960 
Lys Pro Ala Leu His Lys Leu Ala Glu Glu Thr Lys Ala Leu Glu Lys
                965                 970                 975     
Asn Val His Pro Asp Val Glu Lys Leu Tyr Lys Gln Glu Phe Asp Asp
            980                 985                 990         
Val Gln Gly Lys Trp Asn Lys Leu Lys Val Leu Val Ser Lys Asp Leu
        995                 1000                1005            
His Leu Leu Glu Glu Ile Ala Leu Thr Leu Arg Ala Phe Glu Ala Asp
    1010                1015                1020                
Ser Thr Val Ile Glu Lys Trp Met Asp Gly Val Lys Asp Phe Leu Met
1025                1030                1035                1040
Lys Gln Gln Ala Ala Gln Gly Asp Asp Ala Gly Leu Gln Arg Gln Leu
                1045                1050                1055    
Asp Gln Cys Ser Ala Phe Val Asn Glu Ile Glu Thr Ile Glu Ser Ser
            1060                1065                1070        
Leu Lys Asn Met Lys Glu Ile Glu Thr Asn Leu Arg Ser Gly Pro Val
        1075                1080                1085            
Ala Gly Ile Lys Thr Trp Val Gln Thr Arg Leu Gly Asp Tyr Gln Thr
    1090                1095                1100                
Gln Leu Glu Lys Leu Ser Lys Glu Ile Ala Thr Gln Lys Ser Arg Leu
1105                1110                1115                1120
Ser Glu Ser Gln Glu Lys Ala Ala Asn Leu Lys Lys Asp Leu Ala Glu
                1125                1130                1135    
Met Gln Glu Trp Met Thr Gln Ala Glu Glu Glu Tyr Leu Glu Arg Asp
            1140                1145                1150        
Phe Glu Tyr Lys Ser Pro Glu Glu Leu Glu Ser Ala Val Glu Glu Met
        1155                1160                1165            
Lys Arg Ala Lys Glu Asp Val Leu Gln Lys Glu Val Arg Val Lys Ile
    1170                1175                1180                
Leu Lys Asp Asn Ile Lys Leu Leu Ala Ala Lys Val Pro Ser Gly Gly
1185                1190                1195                1200
Gln Glu Leu Thr Ser Glu Leu Asn Val Val Leu Glu Asn Tyr Gln Leu
                1205                1210                1215    
Leu Cys Asn Arg Ile Arg Gly Lys Cys His Thr Leu Glu Glu Val Trp
            1220                1225                1230        
Ser Cys Trp Ile Glu Leu Leu His Tyr Leu Asp Leu Glu Thr Thr Trp
        1235                1240                1245            
Leu Asn Thr Leu Glu Glu Arg Met Lys Ser Thr Glu Val Leu Pro Glu
    1250                1255                1260                
Lys Thr Asp Ala Val Asn Glu Ala Leu Glu Ser Leu Glu Ser Val Leu
1265                1270                1275                1280
Arg His Pro Ala Asp Asn Arg Thr Gln Ile Arg Glu Leu Gly Gln Thr
                1285                1290                1295    
Leu Ile Asp Gly Gly Ile Leu Asp Asp Ile Ile Ser Glu Lys Leu Glu
            1300                1305                1310        
Ala Phe Asn Ser Arg Tyr Glu Asp Leu Ser His Leu Ala Glu Ser Lys
        1315                1320                1325            
Gln Ile Ser Leu Glu Lys Gln Leu Gln Val Leu Arg Glu Thr Asp Gln
    1330                1335                1340                
Met Leu Gln Val Leu Gln Glu Ser Leu Gly Glu Leu Asp Lys Gln Leu
1345                1350                1355                1360
Thr Thr Tyr Leu Thr Asp Arg Ile Asp Ala Phe Gln Val Pro Gln Glu
                1365                1370                1375    
Ala Gln Lys Ile Gln Ala Glu Ile Ser Ala His Glu Leu Thr Leu Glu
            1380                1385                1390        
Glu Leu Arg Arg Asn Met Arg Ser Gln Pro Leu Thr Ser Pro Glu Ser
        1395                1400                1405            
Arg Thr Ala Arg Gly Gly Ser Gln Met Asp Val Leu Gln Arg Lys Leu
    1410                1415                1420                
Arg Glu Val Ser Thr Lys Phe Gln Leu Phe Gln Lys Pro Ala Asn Phe
1425                1430                1435                1440
Glu Gln Arg Met Leu Asp Cys Lys Arg Val Leu Asp Gly Val Lys Ala
                1445                1450                1455    
Glu Leu His Val Leu Asp Val Lys Asp Val Asp Pro Asp Val Ile Gln
            1460                1465                1470        
Thr His Leu Asp Lys Cys Met Lys Leu Tyr Lys Thr Leu Ser Glu Val
        1475                1480                1485            
Lys Leu Glu Val Glu Thr Val Ile Lys Thr Gly Arg His Ile Val Gln
    1490                1495                1500                
Lys Gln Gln Thr Asp Asn Pro Lys Gly Met Asp Glu Gln Leu Thr Ser
1505                1510                1515                1520
Leu Lys Val Leu Tyr Asn Asp Leu Gly Ala Gln Val Thr Glu Gly Lys
                1525                1530                1535    
Gln Asp Leu Glu Arg Ala Ser Gln Leu Ala Arg Lys Met Lys Lys Glu
            1540                1545                1550        
Ala Ala Ser Leu Ser Glu Trp Leu Ser Ala Thr Glu Thr Glu Leu Val
        1555                1560                1565            
Gln Lys Ser Thr Ser Glu Gly Leu Leu Gly Asp Leu Asp Thr Glu Ile
    1570                1575                1580                
Ser Trp Ala Lys Asn Val Leu Lys Asp Leu Glu Lys Arg Lys Ala Asp
1585                1590                1595                1600
Leu Asn Thr Ile Thr Glu Ser Ser Ala Ala Leu Gln Asn Leu Ile Glu
                1605                1610                1615    
Gly Ser Glu Pro Ile Leu Glu Glu Arg Leu Cys Val Leu Asn Ala Gly
            1620                1625                1630        
Trp Ser Arg Val Arg Thr Trp Thr Glu Asp Trp Cys Asn Thr Leu Met
        1635                1640                1645            
Asn His Gln Asn Gln Leu Glu Ile Phe Asp Gly Asn Val Ala His Ile
    1650                1655                1660                
Ser Thr Trp Leu Tyr Gln Ala Glu Ala Leu Leu Asp Glu Ile Glu Lys
1665                1670                1675                1680
Lys Pro Thr Ser Lys Gln Glu Glu Ile Val Lys Arg Leu Val Ser Glu
                1685                1690                1695    
Leu Asp Asp Ala Asn Leu Gln Val Glu Asn Val Arg Asp Gln Ala Leu
            1700                1705                1710        
Ile Leu Met Asn Ala Arg Gly Ser Ser Ser Arg Glu Leu Val Glu Pro
        1715                1720                1725            
Lys Leu Ala Glu Leu Asn Arg Asn Phe Glu Lys Val Ser Gln His Ile
    1730                1735                1740                
Lys Ser Ala Lys Leu Leu Ile Ala Gln Glu Pro Leu Tyr Gln Cys Leu
1745                1750                1755                1760
Val Thr Thr Glu Thr Phe Glu Thr Gly Val Pro Phe Ser Asp Leu Glu
                1765                1770                1775    
Lys Leu Glu Asn Asp Ile Glu Asn Met Leu Lys Phe Val Glu Lys His
            1780                1785                1790        
Leu Glu Ser Ser Asp Glu Asp Glu Lys Met Asp Glu Glu Ser Ala Gln
        1795                1800                1805            
Ile Glu Glu Val Leu Gln Arg Gly Glu Glu Met Leu His Gln Pro Met
    1810                1815                1820                
Glu Asp Asn Lys Lys Glu Lys Ile Arg Leu Gln Leu Leu Leu Leu His
1825                1830                1835                1840
Thr Arg Tyr Asn Lys Ile Lys Ala Ile Pro Ile Gln Gln Arg Lys Met
                1845                1850                1855    
Gly Gln Leu Ala Ser Gly Ile Arg Ser Ser Leu Leu Pro Thr Asp Tyr
            1860                1865                1870        
Leu Val Glu Ile Asn Lys Ile Leu Leu Cys Met Asp Asp Val Glu Leu
        1875                1880                1885            
Ser Leu Asn Val Pro Glu Leu Asn Thr Ala Ile Tyr Glu Asp Phe Ser
    1890                1895                1900                
Phe Gln Glu Asp Ser Leu Lys Asn Ile Lys Asp Gln Leu Asp Lys Leu
1905                1910                1915                1920
Gly Glu Gln Ile Ala Val Ile His Glu Lys Gln Pro Asp Val Ile Leu
                1925                1930                1935    
Glu Ala Ser Gly Pro Glu Ala Ile Gln Ile Arg Asp Thr Leu Thr Gln
            1940                1945                1950        
Leu Asn Ala Lys Trp Asp Arg Ile Asn Arg Met Tyr Ser Asp Arg Lys
        1955                1960                1965            
Gly Cys Phe Asp Arg Ala Met Glu Glu Trp Arg Gln Phe His Cys Asp
    1970                1975                1980                
Leu Asn Asp Leu Thr Gln Trp Ile Thr Glu Ala Glu Glu Leu Leu Val
1985                1990                1995                2000
Asp Thr Cys Ala Pro Gly Gly Ser Leu Asp Leu Glu Lys Ala Arg Ile
                2005                2010                2015    
His Gln Gln Glu Leu Glu Val Gly Ile Ser Ser His Gln Pro Ser Phe
            2020                2025                2030        
Ala Ala Leu Asn Arg Thr Gly Asp Gly Ile Val Gln Lys Leu Ser Gln
        2035                2040                2045            
Ala Asp Gly Ser Phe Leu Lys Glu Lys Leu Ala Gly Leu Asn Gln Arg
    2050                2055                2060                
Trp Asp Ala Ile Val Ala Glu Val Lys Asp Arg Gln Pro Arg Leu Lys
2065                2070                2075                2080
Gly Glu Ser Lys Gln Val Met Lys Tyr Arg His Gln Leu Asp Glu Ile
                2085                2090                2095    
Ile Cys Trp Leu Thr Lys Ala Glu His Ala Met Gln Lys Arg Ser Thr
            2100                2105                2110        
Thr Glu Leu Gly Glu Asn Leu Gln Glu Leu Arg Asp Leu Thr Gln Glu
        2115                2120                2125            
Met Glu Val His Ala Glu Lys Leu Lys Trp Leu Asn Arg Thr Glu Leu
    2130                2135                2140                
Glu Met Leu Ser Asp Lys Ser Leu Ser Leu Pro Glu Arg Asp Lys Ile
2145                2150                2155                2160
Ser Glu Ser Leu Arg Thr Val Asn Met Thr Trp Asn Lys Ile Cys Arg
                2165                2170                2175    
Glu Val Pro Thr Thr Leu Lys Glu Cys Ile Gln Glu Pro Ser Ser Val
            2180                2185                2190        
Ser Gln Thr Arg Ile Ala Ala His Pro Asn Val Gln Lys Val Val Leu
        2195                2200                2205            
Val Ser Ser Ala Ser Asp Ile Pro Val Gln Ser His Arg Thr Ser Glu
    2210                2215                2220                
Ile Ser Ile Pro Ala Asp Leu Asp Lys Thr Ile Thr Glu Leu Ala Asp
2225                2230                2235                2240
Trp Leu Val Leu Ile Asp Gln Met Leu Lys Ser Asn Ile Val Thr Val
                2245                2250                2255    
Gly Asp Val Glu Glu Ile Asn Lys Thr Val Ser Arg Met Lys Ile Thr
            2260                2265                2270        
Lys Ala Asp Leu Glu Gln Arg His Pro Gln Leu Asp Tyr Val Phe Thr
        2275                2280                2285            
Leu Ala Gln Asn Leu Lys Asn Lys Ala Ser Ser Ser Asp Met Arg Thr
    2290                2295                2300                
Ala Ile Thr Glu Lys Leu Glu Arg Val Lys Asn Gln Trp Asp Gly Thr
2305                2310                2315                2320
Gln His Gly Val Glu Leu Arg Gln Gln Gln Leu Glu Asp Met Ile Ile
                2325                2330                2335    
Asp Ser Leu Gln Trp Asp Asp His Arg Glu Glu Thr Glu Glu Leu Met
            2340                2345                2350        
Arg Lys Tyr Glu Ala Arg Leu Tyr Ile Leu Gln Gln Ala Arg Arg Asp
        2355                2360                2365            
Pro Leu Thr Lys Gln Ile Ser Asp Asn Gln Ile Leu Leu Gln Glu Leu
    2370                2375                2380                
Gly Pro Gly Asp Gly Ile Val Met Ala Phe Asp Asn Val Leu Gln Lys
2385                2390                2395                2400
Leu Leu Glu Glu Tyr Gly Ser Asp Asp Thr Arg Asn Val Lys Glu Thr
                2405                2410                2415    
Thr Glu Tyr Leu Lys Thr Ser Trp Ile Asn Leu Lys Gln Ser Ile Ala
            2420                2425                2430        
Asp Arg Gln Asn Ala Leu Glu Ala Glu Trp Arg Thr Val Gln Ala Ser
        2435                2440                2445            
Arg Arg Asp Leu Glu Asn Phe Leu Lys Trp Ile Gln Glu Ala Glu Thr
    2450                2455                2460                
Thr Val Asn Val Leu Val Asp Ala Ser His Arg Glu Asn Ala Leu Gln
2465                2470                2475                2480
Asp Ser Ile Leu Ala Arg Glu Leu Lys Gln Gln Met Gln Asp Ile Gln
                2485                2490                2495    
Ala Glu Ile Asp Ala His Asn Asp Ile Phe Lys Ser Ile Asp Gly Asn
            2500                2505                2510        
Arg Gln Lys Met Val Lys Ala Leu Gly Asn Ser Glu Glu Ala Thr Met
        2515                2520                2525            
Leu Gln His Arg Leu Asp Asp Met Asn Gln Arg Trp Asn Asp Leu Lys
    2530                2535                2540                
Ala Lys Ser Ala Ser Ile Arg Ala His Leu Glu Ala Ser Ala Glu Lys
2545                2550                2555                2560
Trp Asn Arg Leu Leu Met Ser Leu Glu Glu Leu Ile Lys Trp Leu Asn
                2565                2570                2575    
Met Lys Asp Glu Glu Leu Lys Lys Gln Met Pro Ile Gly Gly Asp Val
            2580                2585                2590        
Pro Ala Leu Gln Leu Gln Tyr Asp His Cys Lys Ala Leu Arg Arg Glu
        2595                2600                2605            
Leu Lys Glu Lys Glu Tyr Ser Val Leu Asn Ala Val Asp Gln Ala Arg
    2610                2615                2620                
Val Phe Leu Ala Asp Gln Pro Ile Glu Ala Pro Glu Glu Pro Arg Arg
2625                2630                2635                2640
Asn Leu Gln Ser Lys Thr Glu Leu Thr Pro Glu Glu Arg Ala Gln Lys
                2645                2650                2655    
Ile Ala Lys Ala Met Arg Lys Gln Ser Ser Glu Val Lys Glu Lys Trp
            2660                2665                2670        
Glu Ser Leu Asn Ala Val Thr Ser Asn Trp Gln Lys Gln Val Asp Lys
        2675                2680                2685            
Ala Leu Glu Lys Leu Arg Asp Leu Gln Gly Ala Met Asp Asp Leu Asp
    2690                2695                2700                
Ala Asp Met Lys Glu Ala Glu Ser Val Arg Asn Gly Trp Lys Pro Val
2705                2710                2715                2720
Gly Asp Leu Leu Ile Asp Ser Leu Gln Asp His Ile Glu Lys Ile Met
                2725                2730                2735    
Ala Phe Arg Glu Glu Ile Ala Pro Ile Asn Phe Lys Val Lys Thr Val
            2740                2745                2750        
Asn Asp Leu Ser Ser Gln Leu Ser Pro Leu Asp Leu His Pro Ser Leu
        2755                2760                2765            
Lys Met Ser Arg Gln Leu Asp Asp Leu Asn Met Arg Trp Lys Leu Leu
    2770                2775                2780                
Gln Val Ser Val Asp Asp Arg Leu Lys Gln Leu Gln Glu Ala His Arg
2785                2790                2795                2800
Asp Phe Gly Pro Ser Ser Gln His Phe Leu Ser Thr Ser Val Gln Leu
                2805                2810                2815    
Pro Trp Gln Arg Ser Ile Ser His Asn Lys Val Pro Tyr Tyr Ile Asn
            2820                2825                2830        
His Gln Thr Gln Thr Thr Cys Trp Asp His Pro Lys Met Thr Glu Leu
        2835                2840                2845            
Phe Gln Ser Leu Ala Asp Leu Asn Asn Val Arg Phe Ser Ala Tyr Arg
    2850                2855                2860                
Thr Ala Ile Lys Ile Arg Arg Leu Gln Lys Ala Leu Cys Leu Asp Leu
2865                2870                2875                2880
Leu Glu Leu Ser Thr Thr Asn Glu Ile Phe Lys Gln His Lys Leu Asn
                2885                2890                2895    
Gln Asn Asp Gln Leu Leu Ser Val Pro Asp Val Ile Asn Cys Leu Thr
            2900                2905                2910        
Thr Thr Tyr Asp Gly Leu Glu Gln Met His Lys Asp Leu Val Asn Val
        2915                2920                2925            
Pro Leu Cys Val Asp Met Cys Leu Asn Trp Leu Leu Asn Val Tyr Asp
    2930                2935                2940                
Thr Gly Arg Thr Gly Lys Ile Arg Val Gln Ser Leu Lys Ile Gly Leu
2945                2950                2955                2960
Met Ser Leu Ser Lys Gly Leu Leu Glu Glu Lys Tyr Arg Tyr Leu Phe
                2965                2970                2975    
Lys Glu Val Ala Gly Pro Thr Glu Met Cys Asp Gln Arg Gln Leu Gly
            2980                2985                2990        
Leu Leu Leu His Asp Ala Ile Gln Ile Pro Arg Gln Leu Gly Glu Val
        2995                3000                3005            
Ala Ala Phe Gly Gly Ser Asn Ile Glu Pro Ser Val Arg Ser Cys Phe
    3010                3015                3020                
Gln Gln Asn Asn Asn Lys Pro Glu Ile Ser Val Lys Glu Phe Ile Asp
3025                3030                3035                3040
Trp Met His Leu Glu Pro Gln Ser Met Val Trp Leu Pro Val Leu His
                3045                3050                3055    
Arg Val Ala Ala Ala Glu Thr Ala Lys His Gln Ala Lys Cys Asn Ile
            3060                3065                3070        
Cys Lys Glu Cys Pro Ile Val Gly Phe Arg Tyr Arg Ser Leu Lys His
        3075                3080                3085            
Phe Asn Tyr Asp Val Cys Gln Ser Cys Phe Phe Ser Gly Arg Thr Ala
    3090                3095                3100                
Lys Gly His Lys Leu His Tyr Pro Met Val Glu Tyr Cys Ile Pro Thr
3105                3110                3115                3120
Thr Ser Gly Glu Asp Val Arg Asp Phe Thr Lys Val Leu Lys Asn Lys
                3125                3130                3135    
Phe Arg Ser Lys Lys Tyr Phe Ala Lys His Pro Arg Leu Gly Tyr Leu
            3140                3145                3150        
Pro Val Gln Thr Val Leu Glu Gly Asp Asn Leu Glu Thr Pro Ile Thr
        3155                3160                3165            
Leu Ile Ser Met Trp Pro Glu His Tyr Asp Pro Ser Gln Ser Pro Gln
    3170                3175                3180                
Leu Phe His Asp Asp Thr His Ser Arg Ile Glu Gln Tyr Ala Thr Arg
3185                3190                3195                3200
Leu Ala Gln Met Glu Arg Thr Asn Gly Ser Phe Leu Thr Asp Ser Ser
                3205                3210                3215    
Ser Thr Thr Gly Ser Val Glu Asp Glu His Ala Leu Ile Gln Gln Tyr
            3220                3225                3230        
Cys Gln Thr Leu Gly Gly Glu Ser Pro Val Ser Gln Pro Gln Ser Pro
        3235                3240                3245            
Ala Gln Ile Leu Lys Ser Val Glu Arg Glu Glu Arg Gly Glu Leu Glu
    3250                3255                3260                
Arg Ile Ile Ala Asp Leu Glu Glu Glu Gln Arg Asn Leu Gln Val Glu
3265                3270                3275                3280
Tyr Glu Gln Leu Lys Asp Gln His Leu Arg Arg Gly Leu Pro Val Gly
                3285                3290                3295    
Ser Pro Pro Glu Ser Ile Ile Ser Pro His His Thr Ser Glu Asp Ser
            3300                3305                3310        
Glu Leu Ile Ala Glu Ala Lys Leu Leu Arg Gln His Lys Gly Arg Leu
        3315                3320                3325            
Glu Ala Arg Met Gln Ile Leu Glu Asp His Asn Lys Gln Leu Glu Ser
    3330                3335                3340                
Gln Leu His Arg Leu Arg Gln Leu Leu Glu Gln Pro Glu Ser Asp Ser
3345                3350                3355                3360
Arg Ile Asn Gly Val Ser Pro Trp Ala Ser Pro Gln His Ser Ala Leu
                3365                3370                3375    
Ser Tyr Ser Leu Asp Pro Asp Ala Ser Gly Pro Gln Phe His Gln Ala
            3380                3385                3390        
Ala Gly Glu Asp Leu Leu Ala Pro Pro His Asp Thr Ser Thr Asp Leu
        3395                3400                3405            
Thr Glu Val Met Glu Gln Ile His Ser Thr Phe Pro Ser Cys Cys Pro
    3410                3415                3420                
Asn Val Pro Ser Arg Pro Gln Ala Met
3425                3430            


<210> 732
<211> 3433
<212> PRT
<213> Homo sapiens

<400> 732
Met Ala Lys Tyr Gly Glu His Glu Ala Ser Pro Asp Asn Gly Gln Asn
 1               5                  10                  15      
Glu Phe Ser Asp Ile Ile Lys Ser Arg Ser Asp Glu His Asn Asp Val
            20                  25                  30          
Gln Lys Lys Thr Phe Thr Lys Trp Ile Asn Ala Arg Phe Ser Lys Ser
        35                  40                  45              
Gly Lys Pro Pro Ile Asn Asp Met Phe Thr Asp Leu Lys Asp Gly Arg
    50                  55                  60                  
Lys Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Thr Ser Leu Pro Lys
65                  70                  75                  80  
Glu Arg Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Arg Val
                85                  90                  95      
Leu Gln Val Leu His Gln Asn Asn Val Glu Leu Val Asn Ile Gly Gly
            100                 105                 110         
Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Leu Trp
        115                 120                 125             
Ser Ile Ile Leu His Trp Gln Val Lys Asp Val Met Lys Asp Val Met
    130                 135                 140                 
Ser Asp Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val
145                 150                 155                 160 
Arg Gln Thr Thr Arg Pro Tyr Ser Gln Val Asn Val Leu Asn Phe Thr
                165                 170                 175     
Thr Ser Trp Thr Asp Gly Leu Ala Phe Asn Ala Val Leu His Arg His
            180                 185                 190         
Lys Pro Asp Leu Phe Ser Trp Asp Lys Val Val Lys Met Ser Pro Ile
        195                 200                 205             
Glu Arg Leu Glu His Ala Phe Ser Lys Ala Gln Thr Tyr Leu Gly Ile
    210                 215                 220                 
Glu Lys Leu Leu Asp Pro Glu Asp Val Ala Val Arg Leu Pro Asp Lys
225                 230                 235                 240 
Lys Ser Ile Ile Met Tyr Leu Thr Ser Leu Phe Glu Val Leu Pro Gln
                245                 250                 255     
Gln Val Thr Ile Asp Ala Ile Arg Glu Val Glu Thr Leu Pro Arg Lys
            260                 265                 270         
Tyr Lys Lys Glu Cys Glu Glu Glu Ala Ile Asn Ile Gln Ser Thr Ala
        275                 280                 285             
Pro Glu Glu Glu His Glu Ser Pro Arg Ala Glu Thr Pro Ser Thr Val
    290                 295                 300                 
Thr Glu Val Asp Met Asp Leu Asp Ser Tyr Gln Ile Ala Leu Glu Glu
305                 310                 315                 320 
Val Leu Thr Trp Leu Leu Ser Ala Glu Asp Thr Phe Gln Glu Gln Asp
                325                 330                 335     
Asp Ile Ser Asp Asp Val Glu Glu Val Lys Asp Gln Phe Ala Thr His
            340                 345                 350         
Glu Ala Phe Met Met Glu Leu Thr Ala His Gln Ser Ser Val Gly Ser
        355                 360                 365             
Val Leu Gln Ala Gly Asn Gln Leu Ile Thr Gln Gly Thr Leu Ser Asp
    370                 375                 380                 
Glu Glu Glu Phe Glu Ile Gln Glu Gln Met Thr Leu Leu Asn Ala Arg
385                 390                 395                 400 
Trp Glu Ala Leu Arg Val Glu Ser Met Asp Arg Gln Ser Arg Leu His
                405                 410                 415     
Asp Val Leu Met Glu Leu Gln Lys Lys Gln Leu Gln Gln Leu Ser Ala
            420                 425                 430         
Trp Leu Thr Leu Thr Glu Glu Arg Ile Gln Lys Met Glu Thr Cys Pro
        435                 440                 445             
Leu Asp Asp Asp Val Lys Ser Leu Gln Lys Leu Leu Glu Glu His Lys
    450                 455                 460                 
Ser Leu Gln Ser Asp Leu Glu Ala Glu Gln Val Lys Val Asn Ser Leu
465                 470                 475                 480 
Thr His Met Val Val Ile Val Asp Glu Asn Ser Gly Glu Ser Ala Thr
                485                 490                 495     
Ala Ile Leu Glu Asp Gln Leu Gln Lys Leu Gly Glu Arg Trp Thr Ala
            500                 505                 510         
Val Cys Arg Trp Thr Glu Glu Arg Trp Asn Arg Leu Gln Glu Ile Asn
        515                 520                 525             
Ile Leu Trp Gln Glu Leu Leu Glu Glu Gln Cys Leu Leu Lys Ala Trp
    530                 535                 540                 
Leu Thr Glu Lys Glu Glu Ala Leu Asn Lys Val Gln Thr Ser Asn Phe
545                 550                 555                 560 
Lys Asp Gln Lys Glu Leu Ser Val Ser Val Arg Arg Leu Ala Ile Leu
                565                 570                 575     
Lys Glu Asp Met Glu Met Lys Arg Gln Thr Leu Asp Gln Leu Ser Glu
            580                 585                 590         
Ile Gly Gln Asp Val Gly Gln Leu Leu Asp Asn Ser Lys Ala Ser Lys
        595                 600                 605             
Lys Ile Asn Ser Asp Ser Glu Glu Leu Thr Gln Arg Trp Asp Ser Leu
    610                 615                 620                 
Val Gln Arg Leu Glu Asp Ser Ser Asn Gln Val Thr Gln Ala Val Ala
625                 630                 635                 640 
Lys Leu Gly Met Ser Gln Ile Pro Gln Lys Asp Leu Leu Glu Thr Val
                645                 650                 655     
Arg Val Arg Glu Gln Ala Ile Thr Lys Lys Ser Lys Gln Glu Leu Pro
            660                 665                 670         
Pro Pro Pro Pro Pro Lys Lys Arg Gln Ile His Val Asp Ile Glu Ala
        675                 680                 685             
Lys Lys Lys Phe Asp Ala Ile Ser Ala Glu Leu Leu Asn Trp Ile Leu
    690                 695                 700                 
Lys Trp Lys Thr Ala Ile Gln Thr Thr Glu Ile Lys Glu Tyr Met Lys
705                 710                 715                 720 
Met Gln Asp Thr Ser Glu Met Lys Lys Lys Leu Lys Ala Leu Glu Lys
                725                 730                 735     
Glu Gln Arg Glu Arg Ile Pro Arg Ala Asp Glu Leu Asn Gln Thr Gly
            740                 745                 750         
Gln Ile Leu Val Glu Gln Met Gly Lys Glu Gly Leu Pro Thr Glu Glu
        755                 760                 765             
Ile Lys Asn Val Leu Glu Lys Val Ser Ser Glu Trp Lys Asn Val Ser
    770                 775                 780                 
Gln His Leu Glu Asp Leu Glu Arg Lys Ile Gln Leu Gln Glu Asp Ile
785                 790                 795                 800 
Asn Ala Tyr Phe Lys Gln Leu Asp Glu Leu Glu Lys Val Ile Lys Thr
                805                 810                 815     
Lys Glu Glu Trp Val Lys His Thr Ser Ile Ser Glu Ser Ser Arg Gln
            820                 825                 830         
Ser Leu Pro Ser Leu Lys Asp Ser Cys Gln Arg Glu Leu Thr Asn Leu
        835                 840                 845             
Leu Gly Leu His Pro Lys Ile Glu Met Ala Arg Ala Ser Cys Ser Ala
    850                 855                 860                 
Leu Met Ser Gln Pro Ser Ala Pro Asp Phe Val Gln Arg Gly Phe Asp
865                 870                 875                 880 
Ser Phe Leu Gly Arg Tyr Gln Ala Val Gln Glu Ala Val Glu Asp Arg
                885                 890                 895     
Gln Gln His Leu Glu Asn Glu Leu Lys Gly Gln Pro Gly His Ala Tyr
            900                 905                 910         
Leu Glu Thr Leu Lys Thr Leu Lys Asp Val Leu Asn Asp Ser Glu Asn
        915                 920                 925             
Lys Ala Gln Val Ser Leu Asn Val Leu Asn Asp Leu Ala Lys Val Glu
    930                 935                 940                 
Lys Ala Leu Gln Glu Lys Lys Thr Leu Asp Glu Ile Leu Glu Asn Gln
945                 950                 955                 960 
Lys Pro Ala Leu His Lys Leu Ala Glu Glu Thr Lys Ala Leu Glu Lys
                965                 970                 975     
Asn Val His Pro Asp Val Glu Lys Leu Tyr Lys Gln Glu Phe Asp Asp
            980                 985                 990         
Val Gln Gly Lys Trp Asn Lys Leu Lys Val Leu Val Ser Lys Asp Leu
        995                 1000                1005            
His Leu Leu Glu Glu Ile Ala Leu Thr Leu Arg Ala Phe Glu Ala Asp
    1010                1015                1020                
Ser Thr Val Ile Glu Lys Trp Met Asp Gly Val Lys Asp Phe Leu Met
1025                1030                1035                1040
Lys Gln Gln Ala Ala Gln Gly Asp Asp Ala Gly Leu Gln Arg Gln Leu
                1045                1050                1055    
Asp Gln Cys Ser Ala Phe Val Asn Glu Ile Glu Thr Ile Glu Ser Ser
            1060                1065                1070        
Leu Lys Asn Met Lys Glu Ile Glu Thr Asn Leu Arg Ser Gly Pro Val
        1075                1080                1085            
Ala Gly Ile Lys Thr Trp Val Gln Thr Arg Leu Gly Asp Tyr Gln Thr
    1090                1095                1100                
Gln Leu Glu Lys Leu Ser Lys Glu Ile Ala Thr Gln Lys Ser Arg Leu
1105                1110                1115                1120
Ser Glu Ser Gln Glu Lys Ala Ala Asn Leu Lys Lys Asp Leu Ala Glu
                1125                1130                1135    
Met Gln Glu Trp Met Thr Gln Ala Glu Glu Glu Tyr Leu Glu Arg Asp
            1140                1145                1150        
Phe Glu Tyr Lys Ser Pro Glu Glu Leu Glu Ser Ala Val Glu Glu Met
        1155                1160                1165            
Lys Arg Ala Lys Glu Asp Val Leu Gln Lys Glu Val Arg Val Lys Ile
    1170                1175                1180                
Leu Lys Asp Asn Ile Lys Leu Leu Ala Ala Lys Val Pro Ser Gly Gly
1185                1190                1195                1200
Gln Glu Leu Thr Ser Glu Leu Asn Val Val Leu Glu Asn Tyr Gln Leu
                1205                1210                1215    
Leu Cys Asn Arg Ile Arg Gly Lys Cys His Thr Leu Glu Glu Val Trp
            1220                1225                1230        
Ser Cys Trp Ile Glu Leu Leu His Tyr Leu Asp Leu Glu Thr Thr Trp
        1235                1240                1245            
Leu Asn Thr Leu Glu Glu Arg Met Lys Ser Thr Glu Val Leu Pro Glu
    1250                1255                1260                
Lys Thr Asp Ala Val Asn Glu Ala Leu Glu Ser Leu Glu Ser Val Leu
1265                1270                1275                1280
Arg His Pro Ala Asp Asn Arg Thr Gln Ile Arg Glu Leu Gly Gln Thr
                1285                1290                1295    
Leu Ile Asp Gly Gly Ile Leu Asp Asp Ile Ile Ser Glu Lys Leu Glu
            1300                1305                1310        
Ala Phe Asn Ser Arg Tyr Glu Asp Leu Ser His Leu Ala Glu Ser Lys
        1315                1320                1325            
Gln Ile Ser Leu Glu Lys Gln Leu Gln Val Leu Arg Glu Thr Asp Gln
    1330                1335                1340                
Met Leu Gln Val Leu Gln Glu Ser Leu Gly Glu Leu Asp Lys Gln Leu
1345                1350                1355                1360
Thr Thr Tyr Leu Thr Asp Arg Ile Asp Ala Phe Gln Val Pro Gln Glu
                1365                1370                1375    
Ala Gln Lys Ile Gln Ala Glu Ile Ser Ala His Glu Leu Thr Leu Glu
            1380                1385                1390        
Glu Leu Arg Arg Asn Met Arg Ser Gln Pro Leu Thr Ser Pro Glu Ser
        1395                1400                1405            
Arg Thr Ala Arg Gly Gly Ser Gln Met Asp Val Leu Gln Arg Lys Leu
    1410                1415                1420                
Arg Glu Val Ser Thr Lys Phe Gln Leu Phe Gln Lys Pro Ala Asn Phe
1425                1430                1435                1440
Glu Gln Arg Met Leu Asp Cys Lys Arg Val Leu Asp Gly Val Lys Ala
                1445                1450                1455    
Glu Leu His Val Leu Asp Val Lys Asp Val Asp Pro Asp Val Ile Gln
            1460                1465                1470        
Thr His Leu Asp Lys Cys Met Lys Leu Tyr Lys Thr Leu Ser Glu Val
        1475                1480                1485            
Lys Leu Glu Val Glu Thr Val Ile Lys Thr Gly Arg His Ile Val Gln
    1490                1495                1500                
Lys Gln Gln Thr Asp Asn Pro Lys Gly Met Asp Glu Gln Leu Thr Ser
1505                1510                1515                1520
Leu Lys Val Leu Tyr Asn Asp Leu Gly Ala Gln Val Thr Glu Gly Lys
                1525                1530                1535    
Gln Asp Leu Glu Arg Ala Ser Gln Leu Ala Arg Lys Met Lys Lys Glu
            1540                1545                1550        
Ala Ala Ser Leu Ser Glu Trp Leu Ser Ala Thr Glu Thr Glu Leu Val
        1555                1560                1565            
Gln Lys Ser Thr Ser Glu Gly Leu Leu Gly Asp Leu Asp Thr Glu Ile
    1570                1575                1580                
Ser Trp Ala Lys Asn Val Leu Lys Asp Leu Glu Lys Arg Lys Ala Asp
1585                1590                1595                1600
Leu Asn Thr Ile Thr Glu Ser Ser Ala Ala Leu Gln Asn Leu Ile Glu
                1605                1610                1615    
Gly Ser Glu Pro Ile Leu Glu Glu Arg Leu Cys Val Leu Asn Ala Gly
            1620                1625                1630        
Trp Ser Arg Val Arg Thr Trp Thr Glu Asp Trp Cys Asn Thr Leu Met
        1635                1640                1645            
Asn His Gln Asn Gln Leu Glu Ile Phe Asp Gly Asn Val Ala His Ile
    1650                1655                1660                
Ser Thr Trp Leu Tyr Gln Ala Glu Ala Leu Leu Asp Glu Ile Glu Lys
1665                1670                1675                1680
Lys Pro Thr Ser Lys Gln Glu Glu Ile Val Lys Arg Leu Val Ser Glu
                1685                1690                1695    
Leu Asp Asp Ala Asn Leu Gln Val Glu Asn Val Arg Asp Gln Ala Leu
            1700                1705                1710        
Ile Leu Met Asn Ala Arg Gly Ser Ser Ser Arg Glu Leu Val Glu Pro
        1715                1720                1725            
Lys Leu Ala Glu Leu Asn Arg Asn Phe Glu Lys Val Ser Gln His Ile
    1730                1735                1740                
Lys Ser Ala Lys Leu Leu Ile Ala Gln Glu Pro Leu Tyr Gln Cys Leu
1745                1750                1755                1760
Val Thr Thr Glu Thr Phe Glu Thr Gly Val Pro Phe Ser Asp Leu Glu
                1765                1770                1775    
Lys Leu Glu Asn Asp Ile Glu Asn Met Leu Lys Phe Val Glu Lys His
            1780                1785                1790        
Leu Glu Ser Ser Asp Glu Asp Glu Lys Met Asp Glu Glu Ser Ala Gln
        1795                1800                1805            
Ile Glu Glu Val Leu Gln Arg Gly Glu Glu Met Leu His Gln Pro Met
    1810                1815                1820                
Glu Asp Asn Lys Lys Glu Lys Ile Arg Leu Gln Leu Leu Leu Leu His
1825                1830                1835                1840
Thr Arg Tyr Asn Lys Ile Lys Ala Ile Pro Ile Gln Gln Arg Lys Met
                1845                1850                1855    
Gly Gln Leu Ala Ser Gly Ile Arg Ser Ser Leu Leu Pro Thr Asp Tyr
            1860                1865                1870        
Leu Val Glu Ile Asn Lys Ile Leu Leu Cys Met Asp Asp Val Glu Leu
        1875                1880                1885            
Ser Leu Asn Val Pro Glu Leu Asn Thr Ala Ile Tyr Glu Asp Phe Ser
    1890                1895                1900                
Phe Gln Glu Asp Ser Leu Lys Asn Ile Lys Asp Gln Leu Asp Lys Leu
1905                1910                1915                1920
Gly Glu Gln Ile Ala Val Ile His Glu Lys Gln Pro Asp Val Ile Leu
                1925                1930                1935    
Glu Ala Ser Gly Pro Glu Ala Ile Gln Ile Arg Asp Thr Leu Thr Gln
            1940                1945                1950        
Leu Asn Ala Lys Trp Asp Arg Ile Asn Arg Met Tyr Ser Asp Arg Lys
        1955                1960                1965            
Gly Cys Phe Asp Arg Ala Met Glu Glu Trp Arg Gln Phe His Cys Asp
    1970                1975                1980                
Leu Asn Asp Leu Thr Gln Trp Ile Thr Glu Ala Glu Glu Leu Leu Val
1985                1990                1995                2000
Asp Thr Cys Ala Pro Gly Gly Ser Leu Asp Leu Glu Lys Ala Arg Ile
                2005                2010                2015    
His Gln Gln Glu Leu Glu Val Gly Ile Ser Ser His Gln Pro Ser Phe
            2020                2025                2030        
Ala Ala Leu Asn Arg Thr Gly Asp Gly Ile Val Gln Lys Leu Ser Gln
        2035                2040                2045            
Ala Asp Gly Ser Phe Leu Lys Glu Lys Leu Ala Gly Leu Asn Gln Arg
    2050                2055                2060                
Trp Asp Ala Ile Val Ala Glu Val Lys Asp Arg Gln Pro Arg Leu Lys
2065                2070                2075                2080
Gly Glu Ser Lys Gln Val Met Lys Tyr Arg His Gln Leu Asp Glu Ile
                2085                2090                2095    
Ile Cys Trp Leu Thr Lys Ala Glu His Ala Met Gln Lys Arg Ser Thr
            2100                2105                2110        
Thr Glu Leu Gly Glu Asn Leu Gln Glu Leu Arg Asp Leu Thr Gln Glu
        2115                2120                2125            
Met Glu Val His Ala Glu Lys Leu Lys Trp Leu Asn Arg Thr Glu Leu
    2130                2135                2140                
Glu Met Leu Ser Asp Lys Ser Leu Ser Leu Pro Glu Arg Asp Lys Ile
2145                2150                2155                2160
Ser Glu Ser Leu Arg Thr Val Asn Met Thr Trp Asn Lys Ile Cys Arg
                2165                2170                2175    
Glu Val Pro Thr Thr Leu Lys Glu Cys Ile Gln Glu Pro Ser Ser Val
            2180                2185                2190        
Ser Gln Thr Arg Ile Ala Ala His Pro Asn Val Gln Lys Val Val Leu
        2195                2200                2205            
Val Ser Ser Ala Ser Asp Ile Pro Val Gln Ser His Arg Thr Ser Glu
    2210                2215                2220                
Ile Ser Ile Pro Ala Asp Leu Asp Lys Thr Ile Thr Glu Leu Ala Asp
2225                2230                2235                2240
Trp Leu Val Leu Ile Asp Gln Met Leu Lys Ser Asn Ile Val Thr Val
                2245                2250                2255    
Gly Asp Val Glu Glu Ile Asn Lys Thr Val Ser Arg Met Lys Ile Thr
            2260                2265                2270        
Lys Ala Asp Leu Glu Gln Arg His Pro Gln Leu Asp Tyr Val Phe Thr
        2275                2280                2285            
Leu Ala Gln Asn Leu Lys Asn Lys Ala Ser Ser Ser Asp Met Arg Thr
    2290                2295                2300                
Ala Ile Thr Glu Lys Leu Glu Arg Val Lys Asn Gln Trp Asp Gly Thr
2305                2310                2315                2320
Gln His Gly Val Glu Leu Arg Gln Gln Gln Leu Glu Asp Met Ile Ile
                2325                2330                2335    
Asp Ser Leu Gln Trp Asp Asp His Arg Glu Glu Thr Glu Glu Leu Met
            2340                2345                2350        
Arg Lys Tyr Glu Ala Arg Leu Tyr Ile Leu Gln Gln Ala Arg Arg Asp
        2355                2360                2365            
Pro Leu Thr Lys Gln Ile Ser Asp Asn Gln Ile Leu Leu Gln Glu Leu
    2370                2375                2380                
Gly Pro Gly Asp Gly Ile Val Met Ala Phe Asp Asn Val Leu Gln Lys
2385                2390                2395                2400
Leu Leu Glu Glu Tyr Gly Ser Asp Asp Thr Arg Asn Val Lys Glu Thr
                2405                2410                2415    
Thr Glu Tyr Leu Lys Thr Ser Trp Ile Asn Leu Lys Gln Ser Ile Ala
            2420                2425                2430        
Asp Arg Gln Asn Ala Leu Glu Ala Glu Trp Arg Thr Val Gln Ala Ser
        2435                2440                2445            
Arg Arg Asp Leu Glu Asn Phe Leu Lys Trp Ile Gln Glu Ala Glu Thr
    2450                2455                2460                
Thr Val Asn Val Leu Val Asp Ala Ser His Arg Glu Asn Ala Leu Gln
2465                2470                2475                2480
Asp Ser Ile Leu Ala Arg Glu Leu Lys Gln Gln Met Gln Asp Ile Gln
                2485                2490                2495    
Ala Glu Ile Asp Ala His Asn Asp Ile Phe Lys Ser Ile Asp Gly Asn
            2500                2505                2510        
Arg Gln Lys Met Val Lys Ala Leu Gly Asn Ser Glu Glu Ala Thr Met
        2515                2520                2525            
Leu Gln His Arg Leu Asp Asp Met Asn Gln Arg Trp Asn Asp Leu Lys
    2530                2535                2540                
Ala Lys Ser Ala Ser Ile Arg Ala His Leu Glu Ala Ser Ala Glu Lys
2545                2550                2555                2560
Trp Asn Arg Leu Leu Met Ser Leu Glu Glu Leu Ile Lys Trp Leu Asn
                2565                2570                2575    
Met Lys Asp Glu Glu Leu Lys Lys Gln Met Pro Ile Gly Gly Asp Val
            2580                2585                2590        
Pro Ala Leu Gln Leu Gln Tyr Asp His Cys Lys Ala Leu Arg Arg Glu
        2595                2600                2605            
Leu Lys Glu Lys Glu Tyr Ser Val Leu Asn Ala Val Asp Gln Ala Arg
    2610                2615                2620                
Val Phe Leu Ala Asp Gln Pro Ile Glu Ala Pro Glu Glu Pro Arg Arg
2625                2630                2635                2640
Asn Leu Gln Ser Lys Thr Glu Leu Thr Pro Glu Glu Arg Ala Gln Lys
                2645                2650                2655    
Ile Ala Lys Ala Met Arg Lys Gln Ser Ser Glu Val Lys Glu Lys Trp
            2660                2665                2670        
Glu Ser Leu Asn Ala Val Thr Ser Asn Trp Gln Lys Gln Val Asp Lys
        2675                2680                2685            
Ala Leu Glu Lys Leu Arg Asp Leu Gln Gly Ala Met Asp Asp Leu Asp
    2690                2695                2700                
Ala Asp Met Lys Glu Ala Glu Ser Val Arg Asn Gly Trp Lys Pro Val
2705                2710                2715                2720
Gly Asp Leu Leu Ile Asp Ser Leu Gln Asp His Ile Glu Lys Ile Met
                2725                2730                2735    
Ala Phe Arg Glu Glu Ile Ala Pro Ile Asn Phe Lys Val Lys Thr Val
            2740                2745                2750        
Asn Asp Leu Ser Ser Gln Leu Ser Pro Leu Asp Leu His Pro Ser Leu
        2755                2760                2765            
Lys Met Ser Arg Gln Leu Asp Asp Leu Asn Met Arg Trp Lys Leu Leu
    2770                2775                2780                
Gln Val Ser Val Asp Asp Arg Leu Lys Gln Leu Gln Glu Ala His Arg
2785                2790                2795                2800
Asp Phe Gly Pro Ser Ser Gln His Phe Leu Ser Thr Ser Val Gln Leu
                2805                2810                2815    
Pro Trp Gln Arg Ser Ile Ser His Asn Lys Val Pro Tyr Tyr Ile Asn
            2820                2825                2830        
His Gln Thr Gln Thr Thr Cys Trp Asp His Pro Lys Met Thr Glu Leu
        2835                2840                2845            
Phe Gln Ser Leu Ala Asp Leu Asn Asn Val Arg Phe Ser Ala Tyr Arg
    2850                2855                2860                
Thr Ala Ile Lys Ile Arg Arg Leu Gln Lys Ala Leu Cys Leu Asp Leu
2865                2870                2875                2880
Leu Glu Leu Ser Thr Thr Asn Glu Ile Phe Lys Gln His Lys Leu Asn
                2885                2890                2895    
Gln Asn Asp Gln Leu Leu Ser Val Pro Asp Val Ile Asn Cys Leu Thr
            2900                2905                2910        
Thr Thr Tyr Asp Gly Leu Glu Gln Met His Lys Asp Leu Val Asn Val
        2915                2920                2925            
Pro Leu Cys Val Asp Met Cys Leu Asn Trp Leu Leu Asn Val Tyr Asp
    2930                2935                2940                
Thr Gly Arg Thr Gly Lys Ile Arg Val Gln Ser Leu Lys Ile Gly Leu
2945                2950                2955                2960
Met Ser Leu Ser Lys Gly Leu Leu Glu Glu Lys Tyr Arg Tyr Leu Phe
                2965                2970                2975    
Lys Glu Val Ala Gly Pro Thr Glu Met Cys Asp Gln Arg Gln Leu Gly
            2980                2985                2990        
Leu Leu Leu His Asp Ala Ile Gln Ile Pro Arg Gln Leu Gly Glu Val
        2995                3000                3005            
Ala Ala Phe Gly Gly Ser Asn Ile Glu Pro Ser Val Arg Ser Cys Phe
    3010                3015                3020                
Gln Gln Asn Asn Asn Lys Pro Glu Ile Ser Val Lys Glu Phe Ile Asp
3025                3030                3035                3040
Trp Met His Leu Glu Pro Gln Ser Met Val Trp Leu Pro Val Leu His
                3045                3050                3055    
Arg Val Ala Ala Ala Glu Thr Ala Lys His Gln Ala Lys Cys Asn Ile
            3060                3065                3070        
Cys Lys Glu Cys Pro Ile Val Gly Phe Arg Tyr Arg Ser Leu Lys His
        3075                3080                3085            
Phe Asn Tyr Asp Val Cys Gln Ser Cys Phe Phe Ser Gly Arg Thr Ala
    3090                3095                3100                
Lys Gly His Lys Leu His Tyr Pro Met Val Glu Tyr Cys Ile Pro Thr
3105                3110                3115                3120
Thr Ser Gly Glu Asp Val Arg Asp Phe Thr Lys Val Leu Lys Asn Lys
                3125                3130                3135    
Phe Arg Ser Lys Lys Tyr Phe Ala Lys His Pro Arg Leu Gly Tyr Leu
            3140                3145                3150        
Pro Val Gln Thr Val Leu Glu Gly Asp Asn Leu Glu Thr Pro Ile Thr
        3155                3160                3165            
Leu Ile Ser Met Trp Pro Glu His Tyr Asp Pro Ser Gln Ser Pro Gln
    3170                3175                3180                
Leu Phe His Asp Asp Thr His Ser Arg Ile Glu Gln Tyr Ala Thr Arg
3185                3190                3195                3200
Leu Ala Gln Met Glu Arg Thr Asn Gly Ser Phe Leu Thr Asp Ser Ser
                3205                3210                3215    
Ser Thr Thr Gly Ser Val Glu Asp Glu His Ala Leu Ile Gln Gln Tyr
            3220                3225                3230        
Cys Gln Thr Leu Gly Gly Glu Ser Pro Val Ser Gln Pro Gln Ser Pro
        3235                3240                3245            
Ala Gln Ile Leu Lys Ser Val Glu Arg Glu Glu Arg Gly Glu Leu Glu
    3250                3255                3260                
Arg Ile Ile Ala Asp Leu Glu Glu Glu Gln Arg Asn Leu Gln Val Glu
3265                3270                3275                3280
Tyr Glu Gln Leu Lys Asp Gln His Leu Arg Arg Gly Leu Pro Val Gly
                3285                3290                3295    
Ser Pro Pro Glu Ser Ile Ile Ser Pro His His Thr Ser Glu Asp Ser
            3300                3305                3310        
Glu Leu Ile Ala Glu Ala Lys Leu Leu Arg Gln His Lys Gly Arg Leu
        3315                3320                3325            
Glu Ala Arg Met Gln Ile Leu Glu Asp His Asn Lys Gln Leu Glu Ser
    3330                3335                3340                
Gln Leu His Arg Leu Arg Gln Leu Leu Glu Gln Pro Glu Ser Asp Ser
3345                3350                3355                3360
Arg Ile Asn Gly Val Ser Pro Trp Ala Ser Pro Gln His Ser Ala Leu
                3365                3370                3375    
Ser Tyr Ser Leu Asp Pro Asp Ala Ser Gly Pro Gln Phe His Gln Ala
            3380                3385                3390        
Ala Gly Glu Asp Leu Leu Ala Pro Pro His Asp Thr Ser Thr Asp Leu
        3395                3400                3405            
Thr Glu Val Met Glu Gln Ile His Ser Thr Phe Pro Ser Cys Cys Pro
    3410                3415                3420                
Asn Val Pro Ser Arg Pro Gln Ala Met
3425                3430            


<210> 733
<211> 376
<212> PRT
<213> Homo sapiens

<400> 733
Met Ala Asp Tyr Trp Lys Ser Gln Pro Lys Lys Phe Cys Asp Tyr Cys
 1               5                  10                  15      
Lys Cys Trp Ile Ala Asp Asn Arg Pro Ser Val Glu Phe His Glu Arg
            20                  25                  30          
Gly Lys Asn His Lys Glu Asn Val Ala Lys Arg Ile Ser Glu Ile Lys
        35                  40                  45              
Gln Lys Ser Leu Asp Lys Ala Lys Glu Glu Glu Lys Ala Ser Lys Glu
    50                  55                  60                  
Phe Ala Ala Met Glu Ala Ala Ala Leu Lys Ala Tyr Gln Glu Asp Leu
65                  70                  75                  80  
Lys Arg Leu Gly Leu Glu Ser Glu Ile Leu Glu Pro Ser Ile Thr Pro
                85                  90                  95      
Val Thr Ser Thr Ile Pro Pro Thr Ser Thr Ser Asn Gln Gln Lys Glu
            100                 105                 110         
Lys Lys Glu Lys Lys Lys Arg Lys Lys Asp Pro Ser Lys Gly Arg Trp
        115                 120                 125             
Val Glu Gly Ile Thr Ser Glu Gly Tyr His Tyr Tyr Tyr Asp Leu Ile
    130                 135                 140                 
Ser Gly Ala Ser Gln Trp Glu Lys Pro Glu Gly Phe Gln Gly Asp Leu
145                 150                 155                 160 
Lys Lys Thr Ala Val Lys Thr Val Trp Val Glu Gly Leu Ser Glu Asp
                165                 170                 175     
Gly Phe Thr Tyr Tyr Tyr Asn Thr Glu Thr Gly Glu Ser Arg Trp Glu
            180                 185                 190         
Lys Pro Asp Asp Phe Ile Pro His Thr Ser Asp Leu Pro Ser Ser Lys
        195                 200                 205             
Val Asn Glu Asn Ser Leu Gly Thr Leu Asp Glu Ser Lys Ser Ser Asp
    210                 215                 220                 
Ser His Ser Asp Ser Asp Gly Glu Gln Glu Ala Glu Glu Gly Gly Val
225                 230                 235                 240 
Ser Thr Glu Thr Glu Lys Pro Lys Ile Lys Phe Lys Glu Lys Asn Lys
                245                 250                 255     
Asn Ser Asp Gly Gly Ser Asp Pro Glu Thr Gln Lys Glu Lys Ser Ile
            260                 265                 270         
Gln Lys Gln Asn Ser Leu Gly Ser Asn Glu Glu Lys Ser Lys Thr Leu
        275                 280                 285             
Lys Lys Ser Asn Pro Tyr Gly Glu Trp Gln Glu Ile Lys Gln Glu Val
    290                 295                 300                 
Glu Ser His Glu Glu Val Asp Leu Glu Leu Pro Ser Thr Glu Asn Glu
305                 310                 315                 320 
Tyr Val Ser Thr Ser Glu Ala Asp Gly Gly Gly Glu Pro Lys Val Val
                325                 330                 335     
Phe Lys Glu Lys Thr Val Thr Ser Leu Gly Val Met Ala Asp Gly Val
            340                 345                 350         
Ala Pro Val Phe Lys Lys Arg Arg Thr Glu Asn Gly Lys Ser Arg Asn
        355                 360                 365             
Leu Arg Gln Arg Gly Asp Asp Gln
    370                 375     


<210> 734
<211> 129
<212> PRT
<213> Homo sapiens

<400> 734
Pro Pro Leu Val Lys Val Thr His His Val Thr Ser Ser Val Thr Thr
 1               5                  10                  15      
Leu Arg Cys Arg Ala Leu Asn Tyr Tyr Pro Gln Asn Ile Thr Met Lys
            20                  25                  30          
Trp Leu Lys Asp Lys Gln Pro Met Asp Ala Lys Glu Phe Glu Pro Lys
        35                  40                  45              
Asp Val Leu Pro Asn Gly Asp Gly Thr Tyr Gln Gly Trp Ile Thr Leu
    50                  55                  60                  
Ala Val Pro Pro Gly Glu Glu Gln Arg Tyr Thr Cys Gln Val Glu His
65                  70                  75                  80  
Pro Gly Leu Asp Gln Pro Leu Ile Val Ile Trp Glu Pro Ser Pro Ser
                85                  90                  95      
Gly Thr Leu Val Ile Gly Val Ile Ser Gly Ile Ala Val Phe Val Val
            100                 105                 110         
Ile Leu Phe Ile Gly Ile Leu Phe Ile Ile Leu Arg Lys Arg Gln Gly
        115                 120                 125             
Ser
    


<210> 735
<211> 362
<212> PRT
<213> Homo sapiens

<400> 735
Met Phe Ser Ser Val Ala His Leu Ala Arg Ala Asn Pro Phe Asn Thr
 1               5                  10                  15      
Pro His Leu Gln Leu Val His Asp Gly Leu Gly Asp Leu Arg Ser Ser
            20                  25                  30          
Ser Pro Gly Pro Thr Gly Gln Pro Arg Arg Pro Arg Asn Leu Ala Ala
        35                  40                  45              
Ala Ala Val Glu Glu Gln Tyr Ser Cys Asp Tyr Gly Ser Gly Arg Phe
    50                  55                  60                  
Phe Ile Leu Cys Gly Leu Gly Gly Ile Ile Ser Cys Gly Thr Thr His
65                  70                  75                  80  
Thr Ala Leu Val Pro Leu Asp Leu Val Lys Cys Arg Met Gln Val Asp
                85                  90                  95      
Pro Gln Lys Tyr Lys Gly Ile Phe Asn Gly Phe Ser Val Thr Leu Lys
            100                 105                 110         
Glu Asp Gly Val Arg Gly Leu Ala Lys Gly Trp Ala Pro Thr Phe Leu
        115                 120                 125             
Gly Tyr Ser Met Gln Gly Leu Cys Lys Phe Gly Phe Tyr Glu Val Phe
    130                 135                 140                 
Lys Val Leu Tyr Ser Asn Met Leu Gly Glu Glu Asn Thr Tyr Leu Trp
145                 150                 155                 160 
Arg Thr Ser Leu Tyr Leu Ala Ala Ser Ala Ser Ala Glu Phe Phe Ala
                165                 170                 175     
Asp Ile Ala Leu Ala Pro Met Glu Ala Ala Lys Val Arg Ile Gln Thr
            180                 185                 190         
Gln Pro Gly Tyr Ala Asn Thr Leu Arg Asp Ala Ala Pro Lys Met Tyr
        195                 200                 205             
Lys Glu Glu Gly Leu Lys Ala Phe Tyr Lys Gly Val Ala Pro Leu Trp
    210                 215                 220                 
Met Arg Gln Ile Pro Tyr Thr Met Met Lys Phe Ala Cys Phe Glu Arg
225                 230                 235                 240 
Thr Val Glu Ala Leu Tyr Lys Phe Val Val Pro Lys Pro Arg Ser Glu
                245                 250                 255     
Cys Ser Lys Pro Glu Gln Leu Val Val Thr Phe Val Ala Gly Tyr Ile
            260                 265                 270         
Ala Gly Val Phe Cys Ala Ile Val Ser His Pro Ala Asp Ser Val Val
        275                 280                 285             
Ser Val Leu Asn Lys Glu Lys Gly Ser Ser Ala Ser Leu Val Leu Lys
    290                 295                 300                 
Arg Leu Gly Phe Lys Gly Val Trp Lys Gly Leu Phe Ala Arg Ile Ile
305                 310                 315                 320 
Met Ile Gly Thr Leu Thr Ala Leu Gln Trp Phe Ile Tyr Asp Ser Val
                325                 330                 335     
Lys Val Tyr Phe Arg Leu Pro Arg Pro Pro Pro Pro Glu Met Pro Glu
            340                 345                 350         
Ser Leu Lys Lys Lys Leu Gly Leu Thr Gln
        355                 360         


<210> 736
<211> 129
<212> PRT
<213> Homo sapiens

<400> 736
Met Ser Phe Pro Lys Tyr Lys Pro Ser Ser Leu Arg Thr Leu Pro Glu
 1               5                  10                  15      
Thr Leu Asp Pro Ala Glu Tyr Asn Ile Ser Pro Glu Thr Arg Arg Ala
            20                  25                  30          
Gln Ala Glu Arg Leu Ala Ile Arg Ala Gln Leu Lys Arg Glu Tyr Leu
        35                  40                  45              
Leu Gln Tyr Asn Asp Pro Asn Arg Arg Gly Leu Ile Glu Asn Pro Ala
    50                  55                  60                  
Leu Leu Arg Trp Ala Tyr Ala Arg Thr Ile Asn Val Tyr Pro Asn Phe
65                  70                  75                  80  
Arg Pro Thr Pro Lys Asn Ser Leu Met Gly Ala Leu Cys Gly Phe Gly
                85                  90                  95      
Pro Leu Ile Phe Ile Tyr Tyr Ile Ile Lys Thr Glu Arg Asp Arg Lys
            100                 105                 110         
Glu Lys Leu Ile Gln Glu Gly Lys Leu Asp Arg Thr Phe His Leu Ser
        115                 120                 125             
Tyr
    


<210> 737
<211> 62
<212> PRT
<213> Homo sapiens

<400> 737
Met Ala Ala Ala Thr Leu Thr Ser Lys Leu Tyr Ser Leu Leu Phe Arg
 1               5                  10                  15      
Arg Thr Ser Thr Phe Ala Leu Thr Ile Ile Val Gly Val Met Phe Phe
            20                  25                  30          
Glu Arg Ala Phe Asp Gln Gly Ala Asp Ala Ile Tyr Asp His Ile Asn
        35                  40                  45              
Glu Gly Val Arg Ala Cys Ala Ile Pro Asp Leu Gly Pro Ala
    50                  55                  60          


<210> 738
<211> 1332
<212> PRT
<213> Homo sapiens

<400> 738
Met Gln Gln Ala Pro Gln Pro Tyr Glu Phe Phe Ser Glu Glu Asn Ser
 1               5                  10                  15      
Pro Lys Trp Arg Gly Leu Leu Val Ser Ala Leu Arg Lys Val Gln Val
            20                  25                  30          
Gln Val His Pro Thr Leu Ser Ala Asn Glu Glu Ser Leu Tyr Tyr Ile
        35                  40                  45              
Glu Glu Leu Ile Phe Gln Leu Leu Asn Lys Leu Cys Met Ala Gln Pro
    50                  55                  60                  
Arg Thr Val Gln Asp Val Glu Glu Arg Val Gln Lys Thr Phe Pro His
65                  70                  75                  80  
Pro Ile Asp Lys Trp Ala Ile Ala Asp Ala Gln Ser Ala Ile Glu Lys
                85                  90                  95      
Arg Lys Arg Arg Asn Pro Leu Leu Leu Pro Val Asp Lys Ile His Pro
            100                 105                 110         
Ser Leu Lys Glu Val Leu Gly Tyr Lys Val Asp Tyr His Val Ser Leu
        115                 120                 125             
Tyr Ile Val Ala Val Leu Glu Tyr Ile Ser Ala Asp Ile Leu Lys Leu
    130                 135                 140                 
Ala Gly Asn Tyr Val Phe Asn Ile Arg His Tyr Glu Ile Ser Gln Gln
145                 150                 155                 160 
Asp Ile Lys Val Ser Met Cys Ala Asp Lys Val Leu Met Asp Met Phe
                165                 170                 175     
Asp Gln Asp Asp Ile Gly Leu Val Ser Leu Cys Glu Asp Glu Pro Cys
            180                 185                 190         
Ser Ser Gly Glu Leu Asn Tyr Tyr Asp Leu Val Arg Thr Glu Ile Ala
        195                 200                 205             
Glu Glu Arg Gln Tyr Leu Arg Glu Leu Asn Met Ile Ile Lys Val Phe
    210                 215                 220                 
Arg Glu Ala Phe Leu Ser Asp Arg Lys Leu Phe Lys Pro Ser Val Tyr
225                 230                 235                 240 
Glu Lys Ile Phe Ser Asn Ile Ser Asp Ile His Glu Leu Thr Val Lys
                245                 250                 255     
Leu Leu Gly Leu Ile Glu Asp Thr Val Glu Met Thr Asp Glu Ser Ser
            260                 265                 270         
Pro His Pro Leu Ala Gly Ser Cys Phe Glu Asp Leu Ala Glu Glu Gln
        275                 280                 285             
Ala Phe Asp Pro Tyr Glu Thr Leu Ser Gln Asp Ile Leu Ser Pro Glu
    290                 295                 300                 
Phe His Glu His Phe Asn Lys Leu Met Ala Arg Pro Ala Val Ala Leu
305                 310                 315                 320 
His Phe Gln Ser Ile Ala Asp Gly Phe Lys Glu Ala Val Arg Tyr Val
                325                 330                 335     
Leu Pro Arg Leu Met Leu Val Pro Val Tyr His Cys Trp His Tyr Phe
            340                 345                 350         
Glu Leu Leu Lys Gln Leu Lys Ala Cys Ser Glu Glu Gln Glu Asp Arg
        355                 360                 365             
Glu Cys Leu Asn Gln Ala Ile Thr Ala Leu Met Asn His Gln Gly Ser
    370                 375                 380                 
Met Asp Arg Ile Tyr Lys Gln Tyr Ser Pro Arg Arg Arg Pro Gly Asp
385                 390                 395                 400 
Pro Val Cys Pro Phe Tyr Ser His Gln Leu Arg Ser Lys His Leu Ala
                405                 410                 415     
Ile Lys Lys Met Asn Glu Ile Gln Lys Asn Ile Asp Gly Trp Glu Gly
            420                 425                 430         
Lys Asp Ile Gly Gln Cys Cys Asn Glu Phe Ile Met Glu Gly Pro Leu
        435                 440                 445             
Thr Arg Ile Gly Ala Lys His Glu Arg His Ile Phe Leu Phe Asp Gly
    450                 455                 460                 
Leu Met Ile Ser Cys Lys Pro Asn His Gly Gln Thr Arg Leu Pro Gly
465                 470                 475                 480 
Tyr Thr Ser Ala Glu Tyr Arg Leu Lys Glu Lys Phe Val Met Arg Lys
                485                 490                 495     
Ile Gln Ile Cys Asp Lys Glu Asp Thr Cys Glu His Lys His Ala Phe
            500                 505                 510         
Glu Leu Val Ser Lys Asp Glu Asn Ser Ile Ile Phe Ala Ala Lys Ser
        515                 520                 525             
Ala Glu Glu Lys Asn Asn Trp Met Ala Ala Leu Ile Ser Leu His Tyr
    530                 535                 540                 
Arg Ser Thr Leu Asp Arg Met Leu Asp Ser Val Leu Leu Lys Glu Glu
545                 550                 555                 560 
Asn Glu Gln Pro Leu Arg Leu Pro Ser Pro Glu Val Tyr Arg Phe Val
                565                 570                 575     
Val Lys Asp Ser Glu Glu Asn Ile Val Phe Glu Asp Asn Leu Gln Ser
            580                 585                 590         
Arg Ser Gly Ile Pro Ile Ile Lys Gly Gly Thr Val Val Lys Leu Ile
        595                 600                 605             
Glu Arg Leu Thr Tyr His Met Tyr Ala Asp Pro Asn Phe Val Arg Thr
    610                 615                 620                 
Phe Leu Thr Thr Tyr Arg Ser Phe Cys Lys Pro Gln Glu Leu Leu Ser
625                 630                 635                 640 
Leu Leu Ile Glu Arg Phe Glu Ile Pro Glu Pro Glu Pro Thr Asp Ala
                645                 650                 655     
Asp Lys Leu Ala Ile Glu Lys Gly Glu Gln Pro Ile Ser Ala Asp Leu
            660                 665                 670         
Lys Arg Phe Arg Lys Glu Tyr Val Gln Pro Val Gln Leu Arg Val Leu
        675                 680                 685             
Asn Val Phe Arg His Trp Val Asp His His Tyr Tyr Asp Phe Glu Arg
    690                 695                 700                 
Asp Leu Glu Leu Leu Glu Arg Leu Glu Ser Phe Ile Ser Ser Val Arg
705                 710                 715                 720 
Gly Lys Ala Met Lys Lys Trp Val Glu Ser Ile Ala Lys Ile Ile Arg
                725                 730                 735     
Arg Lys Lys Gln Ala Gln Ala Asn Gly Val Ser His Asn Ile Thr Phe
            740                 745                 750         
Glu Ser Pro Pro Pro Pro Ile Glu Trp His Ile Ser Lys Pro Gly Gln
        755                 760                 765             
Phe Glu Thr Phe Asp Leu Met Thr Leu Asp Pro Ile Glu Ile Ala Arg
    770                 775                 780                 
Gln Leu Thr Leu Leu Glu Ser Asp Leu Tyr Arg Lys Val Gln Pro Ser
785                 790                 795                 800 
Glu Leu Val Gly Ser Val Trp Thr Lys Glu Asp Lys Glu Ile Asn Ser
                805                 810                 815     
Pro Asn Leu Leu Lys Met Ile Arg His Thr Thr Asn Leu Thr Leu Trp
            820                 825                 830         
Phe Glu Lys Cys Ile Val Glu Ala Glu Asn Phe Glu Glu Arg Val Ala
        835                 840                 845             
Val Leu Ser Arg Ile Ile Glu Ile Leu Gln Val Phe Gln Asp Leu Asn
    850                 855                 860                 
Asn Phe Asn Gly Val Leu Glu Ile Val Ser Ala Val Asn Ser Val Ser
865                 870                 875                 880 
Val Tyr Arg Leu Asp His Thr Phe Glu Ala Leu Gln Glu Arg Lys Arg
                885                 890                 895     
Lys Ile Leu Asp Glu Ala Val Glu Leu Ser Gln Asp His Phe Lys Lys
            900                 905                 910         
Tyr Leu Val Lys Leu Lys Ser Ile Asn Pro Pro Cys Val Pro Phe Phe
        915                 920                 925             
Gly Ile Tyr Leu Thr Asn Ile Leu Lys Thr Glu Glu Gly Asn Asn Asp
    930                 935                 940                 
Phe Leu Lys Arg Lys Gly Lys Asp Leu Ile Asn Phe Ser Lys Arg Arg
945                 950                 955                 960 
Lys Val Ala Glu Ile Thr Gly Glu Ile Gln Gln Tyr Gln Asn Gln Pro
                965                 970                 975     
Tyr Cys Leu Arg Ile Glu Pro Asp Met Arg Arg Phe Phe Glu Asn Leu
            980                 985                 990         
Asn Pro Met Gly Ser Ala Ser Glu Lys Glu Phe Thr Asp Tyr Leu Phe
        995                 1000                1005            
Asn Lys Ser Leu Glu Ile Glu Pro Arg Asn Cys Lys Gln Pro Pro Arg
    1010                1015                1020                
Phe Pro Arg Lys Ser Thr Phe Ser Leu Lys Ser Pro Gly Ile Arg Pro
1025                1030                1035                1040
Asn Thr Gly Arg His Gly Ser Thr Ser Gly Thr Leu Arg Gly His Pro
                1045                1050                1055    
Thr Pro Leu Glu Arg Glu Pro Cys Lys Ile Ser Phe Ser Arg Ile Ala
            1060                1065                1070        
Glu Thr Glu Leu Glu Ser Thr Val Ser Ala Pro Thr Ser Pro Asn Thr
        1075                1080                1085            
Pro Ser Thr Pro Pro Val Ser Ala Ser Ser Asp Leu Ser Val Phe Leu
    1090                1095                1100                
Asp Val Asp Leu Asn Ser Ser Cys Gly Ser Asn Ser Ile Phe Ala Pro
1105                1110                1115                1120
Val Leu Leu Pro His Ser Lys Ser Phe Phe Ser Ser Cys Gly Ser Leu
                1125                1130                1135    
His Lys Leu Ser Glu Glu Pro Leu Ile Pro Pro Pro Leu Pro Pro Arg
            1140                1145                1150        
Lys Lys Phe Asp His Asp Ala Ser Asn Ser Lys Gly Asn Met Lys Ser
        1155                1160                1165            
Asp Asp Asp Pro Pro Ala Ile Pro Pro Arg Gln Pro Pro Pro Pro Lys
    1170                1175                1180                
Val Lys Pro Arg Val Pro Val Pro Thr Gly Ala Phe Asp Gly Pro Leu
1185                1190                1195                1200
His Ser Pro Pro Pro Pro Pro Pro Arg Asp Pro Leu Pro Asp Thr Pro
                1205                1210                1215    
Pro Pro Val Pro Leu Arg Pro Pro Glu His Phe Ile Asn Cys Pro Phe
            1220                1225                1230        
Asn Leu Gln Pro Pro Pro Leu Gly His Leu His Arg Asp Ser Asp Trp
        1235                1240                1245            
Leu Arg Asp Ile Ser Thr Cys Pro Asn Ser Pro Ser Thr Pro Pro Ser
    1250                1255                1260                
Thr Pro Ser Pro Arg Val Pro Arg Arg Cys Tyr Val Leu Ser Ser Ser
1265                1270                1275                1280
Gln Asn Asn Leu Ala His Pro Pro Ala Pro Pro Val Pro Pro Arg Gln
                1285                1290                1295    
Asn Ser Ser Pro His Leu Pro Lys Leu Pro Pro Lys Thr Tyr Lys Arg
            1300                1305                1310        
Glu Leu Ser His Pro Pro Leu Tyr Arg Leu Pro Leu Leu Glu Asn Ala
        1315                1320                1325            
Glu Thr Pro Gln
    1330        


<210> 739
<211> 270
<212> PRT
<213> Homo sapiens

<400> 739
Met Ala Leu Arg Gly Pro Gly Leu Glu Arg Pro Pro Leu Thr Cys Pro
 1               5                  10                  15      
Glu Leu Arg Gln Glu Gln Cys Cys Gly Gly Cys Gln Val Gly Gly Ala
            20                  25                  30          
Gly Pro Glu Arg Arg Gly Gly Leu Gly Ala Ser Thr Leu Ser Pro Gly
        35                  40                  45              
Pro Asp Pro Leu Gln Pro Cys Val Ala Gln Gln Pro Phe Pro Ser Leu
    50                  55                  60                  
Pro Ser Pro Leu Pro Leu Gln Gly Thr Leu His Ser Ser Pro Pro Gly
65                  70                  75                  80  
Ala Thr Gly Arg Pro Pro Leu Cys Leu Ser Glu Pro Ser Ser Val Ser
                85                  90                  95      
Pro Arg Pro Arg Cys Phe Leu Leu Pro Trp Gly Ser Pro Arg Pro Cys
            100                 105                 110         
Pro Arg Gln Ser Gln Thr Gly Gly Ser Arg Gly Ser Pro Ala Pro Arg
        115                 120                 125             
Pro Ala Glu Ser Gly Ser Ser Ser Arg Thr Thr Glu Gly Gly Ala Ser
    130                 135                 140                 
Cys Pro Pro His Pro Cys His Cys Pro Pro Ala Pro Ser Pro Thr Gln
145                 150                 155                 160 
Gly Leu Glu Asn Ser Trp Arg Gln His Arg Glu Ala Ala Ala Tyr Leu
                165                 170                 175     
His Gly Arg Leu Gln Ala Leu Gly Leu Gln Leu Phe Val Lys Asp Pro
            180                 185                 190         
Ala Leu Arg Leu Pro Thr Val Thr Thr Val Ala Val Pro Ala Gly Tyr
        195                 200                 205             
Asp Trp Arg Asp Ile Val Ser Tyr Val Ile Asp His Phe Asp Ile Glu
    210                 215                 220                 
Ile Met Gly Gly Leu Gly Pro Ser Thr Gly Lys Val Leu Arg Ile Gly
225                 230                 235                 240 
Leu Leu Gly Cys Asn Ala Thr Arg Glu Asn Val Asp Arg Val Thr Glu
                245                 250                 255     
Ala Leu Arg Ala Ala Leu Gln His Cys Pro Lys Lys Lys Leu
            260                 265                 270 


<210> 740
<211> 738
<212> PRT
<213> Homo sapiens

<400> 740
Met Arg Thr Leu Val Asn Ala Leu Ser Gly Gly Gly Gln Glu Ile Lys
 1               5                  10                  15      
Pro Glu Gly Lys Cys Ala His Asn Gly Met Cys Phe Arg Cys Glu Glu
            20                  25                  30          
Val Ala Pro Asp Thr Cys Glu Ala Tyr Pro Tyr Pro Gly Leu Val Val
        35                  40                  45              
Ser Val Ala Gly Lys Glu Gly Pro Asn Pro Asp His Lys Arg Gly Phe
    50                  55                  60                  
Leu Asp Leu Ala Gln Glu Gly Ile Gln Ala Leu Pro Tyr Gln Leu Ser
65                  70                  75                  80  
Ala His Leu Ser Val Trp Thr Leu Lys Gly Glu Glu Arg Met Pro Ser
                85                  90                  95      
Ala Arg Gly Lys Ser Lys Ser Lys Ala Pro Ile Thr Phe Gly Asp Leu
            100                 105                 110         
Ala Ile Tyr Phe Ser Gln Glu Glu Trp Glu Trp Leu Ser Pro Ile Gln
        115                 120                 125             
Lys Asp Leu Tyr Glu Asp Val Met Leu Glu Asn Tyr Arg Asn Leu Val
    130                 135                 140                 
Ser Leu Gly Leu Ser Phe Arg Arg Pro Asn Val Ile Thr Leu Leu Glu
145                 150                 155                 160 
Lys Gly Lys Ala Pro Trp Met Val Glu Pro Val Arg Arg Arg Arg Ala
                165                 170                 175     
Pro Glu Leu Val Thr Val Ala Leu Phe Ser Ser Phe Gly Glu Val Met
            180                 185                 190         
Phe Ser Arg Met Val Leu Met Leu Met Asp Val Cys Gln Tyr Leu Val
        195                 200                 205             
Ile Asp Glu Leu Asp Ser Gly Ser Lys Cys Glu Thr Lys Lys Leu Pro
    210                 215                 220                 
Pro Asn Gln Cys Asn Lys Ser Gly Gln Ser Ile Cys Gln Lys Leu Val
225                 230                 235                 240 
Ser Ala Gln Gln Lys Ala Pro Thr Arg Lys Ser Gly Cys Asn Lys Asn
                245                 250                 255     
Ser Val Leu Val Lys Pro Lys Lys Gly His Ser Gly Lys Lys Pro Leu
            260                 265                 270         
Lys Cys Asn Asp Cys Gly Lys Thr Phe Ser Arg Ser Phe Ser Leu Lys
        275                 280                 285             
Leu His Gln Asn Ile His Thr Gly Glu Lys Pro Phe Glu Cys Ser Asn
    290                 295                 300                 
Cys Arg Lys Ala Phe Arg Gln Ile Ser Ser Ile Leu Leu His Gln Arg
305                 310                 315                 320 
Ile His Ser Gly Lys Lys Ser His Glu Cys Asn Lys Cys Gly Glu Ser
                325                 330                 335     
Phe Asn Gln Arg Thr Thr Leu Ile Leu His Met Arg Ile His Asp Gly
            340                 345                 350         
Lys Glu Ile Leu Asp Cys Gly Lys Ala Leu Ser Gln Cys Gln Ser Phe
        355                 360                 365             
Asn Ile His Gln Lys Ile His Val Val Gly Asn Val Cys Gln Cys Arg
    370                 375                 380                 
Lys Cys Gly Arg Ala Phe Asn Gln Met Ser Ser Leu Leu Leu His Lys
385                 390                 395                 400 
Lys Ile His Asn Gly Lys Lys Thr His Lys Tyr Asn Lys Cys Gly Arg
                405                 410                 415     
Gly Phe Lys Lys Lys Ser Val Phe Val Val His Lys Arg Ile His Ala
            420                 425                 430         
Gly Glu Lys Ile Pro Glu Asn Ala Lys Ala Leu Ser Gln Ser Leu Gln
        435                 440                 445             
Gln Arg Ser His His Leu Glu Asn Pro Phe Lys Cys Arg Lys Cys Gly
    450                 455                 460                 
Lys Leu Phe Asn Arg Ile Ser Pro Leu Met Leu His Gln Arg Ile His
465                 470                 475                 480 
Thr Ser Glu Lys Pro Tyr Lys Cys Asp Lys Cys Asp Lys Phe Phe Arg
                485                 490                 495     
Arg Leu Ser Thr Leu Ile Leu His Leu Arg Ile His Asn Gly Glu Lys
            500                 505                 510         
Leu Tyr Arg Cys Asn Lys Cys Glu Lys Val Cys Asn Arg His Ser Ser
        515                 520                 525             
Leu Ile Gln His Gln Lys Val His Thr Lys Lys Lys Lys Leu Phe Glu
    530                 535                 540                 
Cys Lys Glu Cys Gly Lys Met Phe Ser Gly Thr Ala Asn Leu Lys Ile
545                 550                 555                 560 
His Gln Asn Ile His Ser Glu Glu Lys Pro Phe Lys Cys Asn Lys Cys
                565                 570                 575     
Ser Lys Val Phe Gly Arg Gln Ser Phe Leu Ile Glu His Gln Arg Ile
            580                 585                 590         
His Thr Gly Glu Lys Pro Tyr Gln Cys Glu Glu Cys Gly Lys Ala Phe
        595                 600                 605             
Ser His Arg Ile Ser Leu Thr Arg His Lys Arg Ile His Thr Glu Asp
    610                 615                 620                 
Arg Pro Tyr Glu Cys Asp Gln Cys Gly Lys Ala Phe Ser Gln Ser Ala
625                 630                 635                 640 
His Leu Ala Gln His Glu Arg Ile His Thr Gly Glu Lys Pro Tyr Thr
                645                 650                 655     
Cys Lys Thr Cys Gly Lys Ala Phe Ser Gln Arg Thr Ser Leu Ile Leu
            660                 665                 670         
His Glu Arg Ser His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys
        675                 680                 685             
Gly Lys Ala Phe Ser Ser Gly Ser Asp Leu Ile Arg His Gln Arg Ser
    690                 695                 700                 
His Ser Ser Glu Lys Pro Tyr Glu Cys Ser Lys Cys Gly Lys Ala Tyr
705                 710                 715                 720 
Ser Arg Ser Ser Ser Leu Ile Arg His Gln Asn Thr His Ser Glu Glu
                725                 730                 735     
Lys Ala
        


<210> 741
<211> 5373
<212> PRT
<213> Homo sapiens

<400> 741
Met Phe Pro Val Leu Trp Ala Gly Ile Pro Gly Arg Asp Val Gly Ser
 1               5                  10                  15      
Leu Gln Pro Leu Pro Pro Gly Phe Lys Gln Phe Cys Thr Ser Ala Ser
            20                  25                  30          
Arg Val Ala Val Ile Ala Asp Glu Arg Asp Arg Val Gln Lys Lys Thr
        35                  40                  45              
Phe Thr Lys Trp Val Asn Lys His Leu Met Lys Val Arg Lys His Ile
    50                  55                  60                  
Asn Asp Leu Tyr Glu Asp Leu Arg Asp Gly His Asn Leu Ile Ser Leu
65                  70                  75                  80  
Leu Glu Val Leu Ser Gly Ile Lys Leu Pro Arg Glu Lys Gly Arg Met
                85                  90                  95      
Arg Phe His Arg Leu Gln Asn Val Gln Ile Ala Leu Asp Phe Leu Lys
            100                 105                 110         
Gln Arg Gln Val Lys Leu Val Asn Ile Arg Asn Asp Asp Ile Thr Asp
        115                 120                 125             
Gly Asn Pro Lys Leu Thr Leu Gly Leu Ile Trp Thr Ile Ile Leu His
    130                 135                 140                 
Phe Gln Ile Ser Asp Ile Tyr Ile Ser Gly Glu Ser Gly Asp Met Ser
145                 150                 155                 160 
Ala Lys Glu Lys Leu Leu Leu Trp Thr Gln Lys Val Thr Ala Gly Tyr
                165                 170                 175     
Thr Gly Ile Lys Cys Thr Asn Phe Ser Ser Cys Trp Ser Asp Gly Lys
            180                 185                 190         
Met Phe Asn Ala Leu Ile His Arg Tyr Arg Pro Asp Leu Val Asp Met
        195                 200                 205             
Glu Arg Val Gln Ile Gln Ser Asn Arg Glu Asn Leu Glu Gln Ala Phe
    210                 215                 220                 
Glu Val Ala Glu Arg Leu Gly Val Thr Arg Leu Leu Asp Ala Glu Asp
225                 230                 235                 240 
Val Asp Val Pro Ser Pro Asp Glu Lys Ser Val Ile Thr Tyr Val Ser
                245                 250                 255     
Ser Ile Tyr Asp Ala Phe Pro Lys Val Pro Glu Gly Gly Glu Gly Ile
            260                 265                 270         
Ser Ala Thr Glu Val Asp Ser Arg Trp Gln Glu Tyr Gln Ser Arg Val
        275                 280                 285             
Asp Ser Leu Ile Pro Trp Ile Lys Gln His Thr Ile Leu Met Ser Asp
    290                 295                 300                 
Lys Thr Phe Pro Gln Asn Pro Val Glu Leu Lys Ala Leu Tyr Asn Gln
305                 310                 315                 320 
Tyr Ile His Phe Lys Glu Thr Glu Ile Leu Ala Lys Glu Arg Glu Lys
                325                 330                 335     
Gly Arg Ile Glu Glu Leu Tyr Lys Leu Leu Glu Val Trp Ile Glu Phe
            340                 345                 350         
Gly Arg Ile Lys Leu Pro Gln Gly Tyr His Pro Asn Asp Val Glu Glu
        355                 360                 365             
Glu Trp Gly Lys Leu Ile Ile Glu Met Leu Glu Arg Glu Lys Ser Leu
    370                 375                 380                 
Arg Pro Ala Val Glu Arg Leu Glu Leu Leu Leu Gln Ile Ala Asn Lys
385                 390                 395                 400 
Ile Gln Asn Gly Ala Leu Asn Cys Glu Glu Lys Leu Thr Leu Ala Lys
                405                 410                 415     
Asn Thr Leu Gln Ala Asp Ala Ala His Leu Glu Ser Gly Gln Pro Val
            420                 425                 430         
Gln Cys Glu Ser Asp Val Ile Met Tyr Ile Gln Glu Cys Glu Gly Leu
        435                 440                 445             
Ile Arg Gln Leu Gln Val Asp Leu Gln Ile Leu Arg Asp Glu Asn Tyr
    450                 455                 460                 
Tyr Gln Leu Glu Glu Leu Ala Phe Arg Val Met Arg Leu Gln Asp Glu
465                 470                 475                 480 
Leu Val Thr Leu Arg Leu Glu Cys Thr Asn Leu Tyr Arg Lys Gly His
                485                 490                 495     
Phe Thr Ser Leu Glu Leu Val Pro Pro Ser Thr Leu Thr Thr Thr His
            500                 505                 510         
Leu Lys Ala Glu Pro Leu Thr Lys Ala Thr His Ser Ser Ser Thr Ser
        515                 520                 525             
Trp Phe Arg Lys Pro Met Thr Arg Ala Glu Leu Val Ala Ile Ser Ser
    530                 535                 540                 
Ser Glu Asp Glu Gly Asn Leu Arg Phe Val Tyr Glu Leu Leu Ser Trp
545                 550                 555                 560 
Val Glu Glu Met Gln Met Lys Leu Glu Arg Ala Glu Trp Gly Asn Asp
                565                 570                 575     
Leu Pro Ser Val Glu Leu Gln Leu Glu Thr Gln Gln His Ile His Thr
            580                 585                 590         
Ser Val Glu Glu Leu Gly Ser Ser Val Lys Glu Ala Arg Leu Tyr Glu
        595                 600                 605             
Gly Lys Met Ser Gln Asn Phe His Thr Ser Tyr Ala Glu Thr Leu Gly
    610                 615                 620                 
Lys Leu Glu Thr Gln Tyr Cys Lys Leu Lys Glu Thr Ser Ser Phe Arg
625                 630                 635                 640 
Met Arg His Leu Gln Ser Leu His Lys Phe Val Ser Arg Ala Thr Ala
                645                 650                 655     
Glu Leu Ile Trp Leu Asn Glu Lys Glu Glu Glu Glu Leu Ala Tyr Asp
            660                 665                 670         
Trp Ser Asp Asn Asn Ser Asn Ile Ser Ala Lys Arg Asn Tyr Phe Ser
        675                 680                 685             
Glu Leu Thr Met Glu Leu Glu Glu Lys Gln Asp Val Phe Arg Ser Leu
    690                 695                 700                 
Gln Asp Thr Ala Glu Leu Leu Ser Leu Glu Asn His Pro Ala Lys Gln
705                 710                 715                 720 
Thr Val Glu Ala Tyr Ser Ala Ala Val Gln Ser Gln Leu Gln Trp Met
                725                 730                 735     
Lys Gln Leu Cys Leu Cys Val Glu Gln His Val Lys Glu Asn Thr Ala
            740                 745                 750         
Tyr Phe Gln Phe Phe Ser Asp Ala Arg Glu Leu Glu Ser Phe Leu Arg
        755                 760                 765             
Asn Leu Gln Asp Ser Ile Lys Arg Lys Tyr Ser Cys Asp His Asn Thr
    770                 775                 780                 
Ser Leu Ser Arg Leu Glu Asp Leu Leu Gln Asp Ser Met Asp Glu Lys
785                 790                 795                 800 
Glu Gln Leu Ile Gln Ser Lys Ser Ser Val Ala Ser Leu Val Gly Arg
                805                 810                 815     
Ser Lys Thr Ile Val Gln Leu Lys Pro Arg Ser Pro Asp His Val Leu
            820                 825                 830         
Lys Asn Thr Ile Ser Val Lys Ala Val Cys Asp Tyr Arg Gln Ile Glu
        835                 840                 845             
Ile Thr Ile Cys Lys Asn Asp Glu Cys Val Leu Glu Asp Asn Ser Gln
    850                 855                 860                 
Arg Thr Lys Trp Lys Val Ile Ser Pro Thr Gly Asn Glu Ala Met Val
865                 870                 875                 880 
Pro Ser Val Cys Phe Leu Ile Pro Pro Pro Asn Lys Asp Ala Ile Glu
                885                 890                 895     
Met Ala Ser Arg Val Glu Gln Ser Tyr Gln Lys Val Met Ala Leu Trp
            900                 905                 910         
His Gln Leu His Val Asn Thr Lys Ser Leu Ile Ser Trp Asn Tyr Leu
        915                 920                 925             
Arg Lys Asp Leu Asp Leu Val Gln Thr Trp Asn Leu Glu Lys Leu Arg
    930                 935                 940                 
Ser Ser Ala Pro Gly Glu Cys His Gln Ile Met Lys Asn Leu Gln Ala
945                 950                 955                 960 
His Tyr Glu Asp Phe Leu Gln Asp Ser Arg Asp Ser Val Leu Phe Ser
                965                 970                 975     
Val Ala Asp Arg Leu Arg Leu Glu Glu Glu Val Glu Ala Cys Lys Ala
            980                 985                 990         
Arg Phe Gln His Leu Met Lys Ser Met Glu Asn Glu Asp Lys Glu Glu
        995                 1000                1005            
Thr Val Ala Lys Met Tyr Ile Ser Glu Leu Lys Asn Ile Arg Leu Arg
    1010                1015                1020                
Leu Glu Glu Tyr Glu Gln Arg Val Val Lys Arg Ile Gln Ser Leu Ala
1025                1030                1035                1040
Ser Ser Arg Thr Asp Arg Asp Ala Trp Gln Asp Asn Ala Leu Arg Ile
                1045                1050                1055    
Ala Glu Gln Glu His Thr Gln Glu Asp Leu Gln Gln Leu Arg Ser Asp
            1060                1065                1070        
Leu Asp Ala Val Ser Met Lys Cys Asp Ser Phe Leu His Gln Ser Pro
        1075                1080                1085            
Ser Ser Ser Ser Val Pro Thr Leu Arg Ser Glu Leu Asn Leu Leu Val
    1090                1095                1100                
Glu Lys Met Asp His Val Tyr Gly Leu Ser Thr Val Tyr Leu Asn Lys
1105                1110                1115                1120
Leu Lys Thr Val Asp Val Ile Val Arg Ser Ile Gln Asp Ala Glu Leu
                1125                1130                1135    
Leu Val Lys Gly Tyr Glu Ile Lys Leu Ser Gln Glu Glu Val Val Leu
            1140                1145                1150        
Ala Asp Leu Ser Ala Leu Glu Ala His Trp Ser Thr Leu Arg His Trp
        1155                1160                1165            
Leu Ser Asp Val Lys Asp Lys Asn Ser Val Phe Ser Val Leu Asp Glu
    1170                1175                1180                
Glu Ile Ala Lys Ala Lys Val Val Ala Glu Gln Met Ser Arg Leu Thr
1185                1190                1195                1200
Pro Glu Arg Asn Leu Asp Leu Glu Arg Tyr Gln Glu Lys Gly Ser Gln
                1205                1210                1215    
Leu Gln Glu Arg Trp His Arg Val Ile Ala Gln Leu Glu Ile Arg Gln
            1220                1225                1230        
Ser Glu Leu Glu Ser Ile Gln Glu Val Leu Gly Asp Tyr Arg Ala Cys
        1235                1240                1245            
His Gly Thr Leu Ile Lys Trp Ile Glu Glu Thr Thr Ala Gln Gln Glu
    1250                1255                1260                
Met Met Lys Pro Gly Gln Ala Glu Asp Ser Arg Val Leu Ser Glu Gln
1265                1270                1275                1280
Leu Ser Gln Gln Thr Ala Leu Phe Ala Glu Ile Glu Arg Asn Gln Thr
                1285                1290                1295    
Lys Leu Asp Gln Cys Gln Lys Phe Ser Gln Gln Tyr Ser Thr Ile Val
            1300                1305                1310        
Lys Asp Tyr Glu Leu Gln Leu Met Thr Tyr Lys Ala Phe Val Glu Ser
        1315                1320                1325            
Gln Gln Lys Ser Pro Gly Lys Arg Arg Arg Met Leu Ser Ser Ser Asp
    1330                1335                1340                
Ala Ile Thr Gln Glu Phe Met Asp Leu Arg Thr Arg Tyr Thr Ala Leu
1345                1350                1355                1360
Val Thr Leu Thr Thr Gln His Val Lys Tyr Ile Ser Asp Ala Leu Arg
                1365                1370                1375    
Arg Leu Glu Glu Glu Glu Lys Val Val Glu Glu Glu Lys Gln Glu His
            1380                1385                1390        
Val Glu Lys Val Lys Glu Leu Leu Gly Trp Val Ser Thr Leu Ala Arg
        1395                1400                1405            
Asn Thr Gln Gly Lys Ala Thr Ser Ser Glu Thr Lys Glu Ser Thr Asp
    1410                1415                1420                
Ile Glu Lys Ala Ile Leu Glu Gln Gln Val Leu Ser Glu Glu Leu Thr
1425                1430                1435                1440
Thr Lys Lys Glu Gln Val Ser Glu Ala Ile Lys Thr Ser Gln Ile Phe
                1445                1450                1455    
Leu Ala Lys His Gly His Lys Leu Ser Glu Lys Glu Lys Lys Gln Ile
            1460                1465                1470        
Ser Glu Gln Leu Asn Ala Leu Asn Lys Ala Tyr His Asp Leu Cys Asp
        1475                1480                1485            
Gly Ser Ala Asn Gln Leu Gln Gln Leu Gln Ser Gln Leu Ala His Gln
    1490                1495                1500                
Thr Glu Gln Lys Thr Leu Gln Lys Gln Gln Asn Thr Cys His Gln Gln
1505                1510                1515                1520
Leu Glu Asp Leu Cys Ser Trp Val Gly Gln Ala Glu Arg Ala Leu Ala
                1525                1530                1535    
Gly His Gln Gly Arg Thr Thr Gln Gln Asp Leu Ser Ala Leu Gln Lys
            1540                1545                1550        
Asn Gln Ser Asp Leu Lys Asp Leu Gln Asp Asp Ile Gln Asn Arg Ala
        1555                1560                1565            
Thr Ser Phe Ala Thr Val Val Lys Asp Ile Glu Gly Phe Met Glu Glu
    1570                1575                1580                
Asn Gln Thr Lys Leu Ser Pro Arg Glu Leu Thr Ala Leu Arg Glu Lys
1585                1590                1595                1600
Leu His Gln Ala Lys Glu Gln Tyr Glu Ala Leu Gln Glu Glu Thr Arg
                1605                1610                1615    
Val Ala Gln Lys Glu Leu Glu Glu Ala Val Thr Ser Ala Leu Gln Gln
            1620                1625                1630        
Glu Thr Glu Lys Ser Lys Ala Ala Lys Glu Leu Ala Glu Asn Lys Lys
        1635                1640                1645            
Lys Ile Asp Ala Leu Leu Asp Trp Val Thr Ser Val Gly Ser Ser Gly
    1650                1655                1660                
Gly Gln Leu Leu Thr Asn Leu Pro Gly Met Glu Gln Leu Ser Gly Ala
1665                1670                1675                1680
Ser Leu Glu Lys Gly Ala Leu Asp Thr Thr Asp Gly Tyr Met Gly Val
                1685                1690                1695    
Asn Gln Ala Pro Glu Lys Leu Asp Lys Gln Cys Glu Met Met Lys Ala
            1700                1705                1710        
Arg His Gln Glu Leu Leu Ser Gln Gln Gln Asn Phe Ile Leu Ala Thr
        1715                1720                1725            
Gln Ser Ala Gln Ala Phe Leu Asp Gln His Gly His Asn Leu Thr Pro
    1730                1735                1740                
Glu Glu Gln Gln Met Leu Gln Gln Lys Leu Gly Glu Leu Lys Glu Gln
1745                1750                1755                1760
Tyr Ser Thr Ser Leu Ala Gln Ser Glu Ala Glu Leu Lys Gln Val Gln
                1765                1770                1775    
Thr Leu Gln Asp Glu Leu Gln Lys Phe Leu Gln Asp His Lys Glu Phe
            1780                1785                1790        
Glu Ser Trp Leu Glu Arg Ser Glu Lys Glu Leu Glu Asn Met His Lys
        1795                1800                1805            
Gly Gly Ser Ser Pro Glu Thr Leu Pro Ser Leu Leu Lys Arg Gln Gly
    1810                1815                1820                
Ser Phe Ser Glu Asp Val Ile Ser His Lys Gly Asp Leu Arg Phe Val
1825                1830                1835                1840
Thr Ile Ser Gly Gln Lys Val Leu Asp Met Glu Asn Ser Phe Lys Glu
                1845                1850                1855    
Gly Lys Glu Pro Ser Glu Ile Gly Asn Leu Val Lys Asp Lys Leu Lys
            1860                1865                1870        
Asp Ala Thr Glu Arg Tyr Thr Ala Leu His Ser Lys Cys Thr Arg Leu
        1875                1880                1885            
Gly Ser His Leu Asn Met Leu Leu Gly Gln Tyr His Gln Phe Gln Asn
    1890                1895                1900                
Ser Ala Asp Ser Leu Gln Ala Trp Met Gln Ala Cys Glu Ala Asn Val
1905                1910                1915                1920
Glu Lys Leu Leu Ser Asp Thr Val Ala Ser Asp Pro Gly Val Leu Gln
                1925                1930                1935    
Glu Gln Leu Ala Thr Thr Lys Gln Leu Gln Glu Glu Leu Ala Glu His
            1940                1945                1950        
Gln Val Pro Val Glu Lys Leu Gln Lys Val Ala Arg Asp Ile Met Glu
        1955                1960                1965            
Ile Glu Gly Glu Pro Ala Pro Asp His Arg His Val Gln Glu Thr Thr
    1970                1975                1980                
Asp Ser Ile Leu Ser His Phe Gln Ser Leu Ser Tyr Ser Leu Ala Glu
1985                1990                1995                2000
Arg Ser Ser Leu Leu Gln Lys Ala Ile Ala Gln Ser Gln Ser Val Gln
                2005                2010                2015    
Glu Ser Leu Glu Ser Leu Leu Gln Ser Ile Gly Glu Val Glu Gln Asn
            2020                2025                2030        
Leu Glu Gly Lys Gln Val Ser Ser Leu Ser Ser Gly Val Ile Gln Lys
        2035                2040                2045            
Ala Leu Ala Thr Asn Met Lys Leu Lys Gln Asp Ile Ala Arg Gln Lys
    2050                2055                2060                
Ser Ser Leu Glu Ala Thr Arg Glu Met Val Thr Arg Phe Met Glu Thr
2065                2070                2075                2080
Ala Asp Ser Thr Thr Ala Ala Val Leu Gln Gly Lys Leu Ala Glu Val
                2085                2090                2095    
Ser Gln Arg Phe Glu Gln Leu Cys Leu Gln Gln Gln Glu Lys Glu Ser
            2100                2105                2110        
Ser Leu Lys Lys Leu Leu Pro Gln Ala Glu Met Phe Glu His Leu Ser
        2115                2120                2125            
Gly Lys Leu Gln Gln Phe Met Glu Asn Lys Ser Arg Met Leu Ala Ser
    2130                2135                2140                
Gly Asn Gln Pro Asp Gln Asp Ile Thr His Phe Phe Gln Gln Ile Gln
2145                2150                2155                2160
Glu Leu Asn Leu Glu Met Glu Asp Gln Gln Glu Asn Leu Asp Thr Leu
                2165                2170                2175    
Glu His Leu Val Thr Glu Leu Ser Ser Cys Gly Phe Ala Leu Asp Leu
            2180                2185                2190        
Cys Gln His Gln Asp Arg Val Gln Asn Leu Arg Lys Asp Phe Thr Glu
        2195                2200                2205            
Leu Gln Lys Thr Val Lys Glu Arg Glu Lys Asp Ala Ser Ser Cys Gln
    2210                2215                2220                
Glu Gln Leu Asp Glu Phe Arg Lys Leu Val Arg Thr Phe Gln Lys Trp
2225                2230                2235                2240
Leu Lys Glu Thr Glu Gly Ser Ile Pro Pro Thr Glu Thr Ser Val Ser
                2245                2250                2255    
Ala Lys Glu Leu Glu Lys Gln Ile Glu His Leu Lys Ser Leu Leu Asp
            2260                2265                2270        
Asp Trp Ala Ser Lys Gly Thr Leu Val Glu Glu Ile Asn Cys Lys Gly
        2275                2280                2285            
Thr Ser Leu Glu Asn Leu Ile Met Glu Ile Thr Ala Pro Asp Ser Gln
    2290                2295                2300                
Gly Lys Thr Asp Leu Thr Glu Ile Gln Cys Asp Met Ser Asp Val Asn
2305                2310                2315                2320
Leu Lys Tyr Glu Lys Leu Gly Gly Val Leu His Glu Arg Gln Glu Ser
                2325                2330                2335    
Leu Gln Ala Ile Leu Asn Arg Met Glu Glu Val His Lys Glu Ala Asn
            2340                2345                2350        
Ser Val Leu Gln Trp Leu Glu Ser Lys Glu Glu Val Leu Lys Ser Met
        2355                2360                2365            
Asp Ala Met Ser Ser Pro Thr Lys Thr Glu Thr Val Lys Ala Gln Ala
    2370                2375                2380                
Glu Ser Asn Lys Ala Phe Leu Ala Glu Leu Glu Gln Asn Ser Pro Lys
2385                2390                2395                2400
Ile Gln Lys Val Lys Glu Ala Leu Ala Gly Leu Leu Val Thr Tyr Pro
                2405                2410                2415    
Asn Ser Gln Glu Ala Glu Asn Trp Lys Lys Ile Gln Glu Glu Leu Asn
            2420                2425                2430        
Ser Arg Trp Glu Arg Ala Thr Glu Val Thr Val Ala Arg Gln Arg Gln
        2435                2440                2445            
Leu Glu Glu Ser Ala Ser His Leu Ala Cys Phe Gln Ala Ala Glu Ser
    2450                2455                2460                
Gln Leu Arg Pro Trp Leu Met Glu Lys Glu Leu Met Met Gly Val Leu
2465                2470                2475                2480
Gly Pro Leu Ser Ile Asp Pro Asn Met Leu Asn Ala Gln Lys Gln Gln
                2485                2490                2495    
Val Gln Phe Met Leu Lys Glu Phe Glu Ala Arg Arg Gln Gln His Glu
            2500                2505                2510        
Gln Leu Asn Glu Ala Ala Gln Gly Ile Leu Thr Gly Pro Gly Asp Val
        2515                2520                2525            
Ser Leu Ser Thr Ser Gln Val Gln Lys Glu Leu Gln Ser Ile Asn Gln
    2530                2535                2540                
Lys Trp Val Glu Leu Thr Asp Lys Leu Asn Ser Arg Ser Ser Gln Ile
2545                2550                2555                2560
Asp Gln Ala Ile Val Lys Ser Thr Gln Tyr Gln Glu Leu Leu Gln Asp
                2565                2570                2575    
Leu Ser Glu Lys Val Arg Ala Val Gly Gln Arg Leu Ser Val Gln Ser
            2580                2585                2590        
Ala Ile Ser Thr Gln Pro Glu Ala Val Lys Gln Gln Leu Glu Glu Thr
        2595                2600                2605            
Ser Glu Ile Arg Ser Asp Leu Glu Gln Leu Asp His Glu Val Lys Glu
    2610                2615                2620                
Ala Gln Thr Leu Cys Asp Glu Leu Ser Val Leu Ile Gly Glu Gln Tyr
2625                2630                2635                2640
Leu Lys Asp Glu Leu Lys Lys Arg Leu Glu Thr Val Ala Leu Pro Leu
                2645                2650                2655    
Gln Gly Leu Glu Asp Leu Ala Ala Asp Arg Ile Asn Arg Leu Gln Ala
            2660                2665                2670        
Ala Leu Ala Ser Thr Gln Gln Phe Gln Gln Met Phe Asp Glu Leu Arg
        2675                2680                2685            
Thr Trp Leu Asp Asp Lys Gln Ser Gln Gln Ala Lys Asn Cys Pro Ile
    2690                2695                2700                
Ser Ala Lys Leu Glu Arg Leu Gln Ser Gln Leu Gln Glu Asn Glu Glu
2705                2710                2715                2720
Phe Gln Lys Ser Leu Asn Gln His Ser Gly Ser Tyr Glu Val Ile Val
                2725                2730                2735    
Ala Glu Gly Glu Ser Leu Leu Leu Ser Val Pro Pro Gly Glu Glu Lys
            2740                2745                2750        
Arg Thr Leu Gln Asn Gln Leu Val Glu Leu Lys Asn His Trp Glu Glu
        2755                2760                2765            
Leu Ser Lys Lys Thr Ala Asp Arg Gln Ser Arg Leu Lys Asp Cys Met
    2770                2775                2780                
Gln Lys Ala Gln Lys Tyr Gln Trp His Val Glu Asp Leu Val Pro Trp
2785                2790                2795                2800
Ile Glu Asp Cys Lys Ala Lys Met Ser Glu Leu Arg Val Thr Leu Asp
                2805                2810                2815    
Pro Val Gln Leu Glu Ser Ser Leu Leu Arg Ser Lys Ala Met Leu Asn
            2820                2825                2830        
Glu Val Glu Lys Arg Arg Ser Leu Leu Glu Ile Leu Asn Ser Ala Ala
        2835                2840                2845            
Asp Ile Leu Ile Asn Ser Ser Glu Ala Asp Glu Asp Gly Ile Arg Asp
    2850                2855                2860                
Glu Lys Ala Gly Ile Asn Gln Asn Met Asp Ala Val Thr Glu Glu Leu
2865                2870                2875                2880
Gln Ala Lys Thr Gly Ser Leu Glu Glu Met Thr Gln Arg Leu Arg Glu
                2885                2890                2895    
Phe Gln Glu Ser Phe Lys Asn Ile Glu Lys Lys Val Glu Gly Ala Lys
            2900                2905                2910        
His Gln Leu Glu Ile Phe Asp Ala Leu Gly Ser Gln Ala Cys Ser Asn
        2915                2920                2925            
Lys Asn Leu Glu Lys Leu Arg Ala Gln Gln Glu Val Leu Gln Ala Leu
    2930                2935                2940                
Glu Pro Gln Val Asp Tyr Leu Arg Asn Phe Thr Gln Gly Leu Val Glu
2945                2950                2955                2960
Asp Ala Pro Asp Gly Ser Asp Ala Ser Gln Leu Leu His Gln Ala Glu
                2965                2970                2975    
Val Ala Gln Gln Glu Phe Leu Glu Val Lys Gln Arg Val Asn Ser Gly
            2980                2985                2990        
Cys Val Met Met Glu Asn Lys Leu Glu Gly Ile Gly Gln Phe His Cys
        2995                3000                3005            
Arg Val Arg Glu Met Phe Ser Gln Leu Ala Asp Leu Asp Asp Glu Leu
    3010                3015                3020                
Asp Gly Met Gly Ala Ile Gly Arg Asp Thr Asp Ser Leu Gln Ser Gln
3025                3030                3035                3040
Ile Glu Asp Val Arg Leu Phe Leu Asn Lys Ile His Val Leu Lys Leu
                3045                3050                3055    
Asp Ile Glu Ala Ser Glu Ala Glu Cys Arg His Met Leu Glu Glu Glu
            3060                3065                3070        
Gly Thr Leu Asp Leu Leu Gly Leu Lys Arg Glu Leu Glu Ala Leu Asn
        3075                3080                3085            
Lys Gln Cys Gly Lys Leu Thr Glu Arg Gly Lys Ala Arg Gln Glu Gln
    3090                3095                3100                
Leu Glu Leu Thr Leu Gly Arg Val Glu Asp Phe Tyr Arg Lys Leu Lys
3105                3110                3115                3120
Gly Leu Asn Asp Ala Thr Thr Ala Ala Glu Glu Ala Glu Ala Leu Gln
                3125                3130                3135    
Trp Val Val Gly Thr Glu Val Glu Ile Ile Asn Gln Gln Leu Ala Asp
            3140                3145                3150        
Phe Lys Met Phe Gln Lys Glu Gln Val Asp Pro Leu Gln Met Lys Leu
        3155                3160                3165            
Gln Gln Val Asn Gly Leu Gly Gln Gly Leu Ile Gln Ser Ala Gly Lys
    3170                3175                3180                
Asp Cys Asp Val Gln Gly Leu Glu His Asp Met Glu Glu Ile Asn Ala
3185                3190                3195                3200
Arg Trp Asn Thr Leu Asn Lys Lys Val Ala Gln Arg Ile Ala Gln Leu
                3205                3210                3215    
Gln Glu Ala Leu Leu His Cys Gly Lys Phe Gln Asp Ala Leu Glu Pro
            3220                3225                3230        
Leu Leu Ser Trp Leu Ala Asp Thr Glu Glu Leu Ile Ala Asn Gln Lys
        3235                3240                3245            
Pro Pro Ser Ala Glu Tyr Lys Val Val Lys Ala Gln Ile Gln Glu Gln
    3250                3255                3260                
Lys Leu Leu Gln Arg Leu Leu Asp Asp Arg Lys Ala Thr Val Asp Met
3265                3270                3275                3280
Leu Gln Ala Glu Gly Gly Arg Ile Ala Gln Ser Ala Glu Leu Ala Asp
                3285                3290                3295    
Arg Glu Lys Ile Thr Gly Gln Leu Glu Ser Leu Glu Ser Arg Trp Thr
            3300                3305                3310        
Glu Leu Leu Ser Lys Ala Ala Ala Arg Gln Lys Gln Leu Glu Asp Ile
        3315                3320                3325            
Leu Val Leu Ala Lys Gln Phe His Glu Thr Ala Glu Pro Ile Ser Asp
    3330                3335                3340                
Phe Leu Ser Val Thr Glu Lys Lys Leu Ala Asn Ser Glu Pro Val Gly
3345                3350                3355                3360
Thr Gln Thr Ala Lys Ile Gln Gln Gln Ile Ile Arg His Lys Ala Leu
                3365                3370                3375    
Glu Glu Asp Ile Glu Asn His Ala Thr Asp Val His Gln Ala Val Lys
            3380                3385                3390        
Ile Gly Gln Ser Leu Ser Ser Leu Thr Ser Pro Ala Glu Gln Gly Val
        3395                3400                3405            
Leu Ser Glu Lys Ile Asp Ser Leu Gln Ala Arg Tyr Ser Glu Ile Gln
    3410                3415                3420                
Asp Arg Cys Cys Arg Lys Ala Ala Leu Leu Asp Gln Ala Leu Ser Asn
3425                3430                3435                3440
Ala Arg Leu Phe Gly Glu Asp Glu Val Glu Val Leu Asn Trp Leu Ala
                3445                3450                3455    
Glu Val Glu Asp Lys Leu Ser Ser Val Phe Val Lys Asp Phe Lys Gln
            3460                3465                3470        
Asp Val Leu His Arg Gln His Ala Asp His Leu Ala Leu Asn Glu Glu
        3475                3480                3485            
Ile Val Asn Arg Lys Lys Asn Val Asp Gln Ala Ile Lys Asn Gly Gln
    3490                3495                3500                
Ala Leu Leu Lys Gln Thr Thr Gly Glu Glu Val Leu Leu Ile Gln Glu
3505                3510                3515                3520
Lys Leu Asp Gly Ile Lys Thr Arg Tyr Ala Asp Ile Thr Val Thr Ser
                3525                3530                3535    
Ser Lys Ala Leu Arg Thr Leu Glu Gln Ala Arg Gln Leu Ala Thr Lys
            3540                3545                3550        
Phe Gln Ser Thr Tyr Glu Glu Leu Thr Gly Trp Leu Arg Glu Val Glu
        3555                3560                3565            
Glu Glu Leu Ala Thr Ser Gly Gly Gln Ser Pro Thr Gly Glu Gln Ile
    3570                3575                3580                
Pro Gln Phe Gln Gln Arg Gln Lys Glu Leu Lys Lys Glu Val Met Glu
3585                3590                3595                3600
His Arg Leu Val Leu Asp Thr Val Asn Glu Val Ser Arg Ala Leu Leu
                3605                3610                3615    
Glu Leu Val Pro Trp Arg Ala Arg Glu Gly Leu Asp Lys Leu Val Ser
            3620                3625                3630        
Asp Ala Asn Glu Gln Tyr Lys Leu Val Ser Asp Thr Ile Gly Gln Arg
        3635                3640                3645            
Val Asp Glu Ile Asp Ala Ala Ile Gln Arg Ser Gln Gln Tyr Glu Gln
    3650                3655                3660                
Ala Ala Asp Ala Glu Leu Ala Trp Val Ala Glu Thr Lys Arg Lys Leu
3665                3670                3675                3680
Met Ala Leu Gly Pro Ile Arg Leu Glu Gln Asp Gln Thr Thr Ala Gln
                3685                3690                3695    
Leu Gln Val Gln Lys Ala Phe Ser Ile Asp Ile Ile Arg His Lys Asp
            3700                3705                3710        
Ser Met Asp Glu Leu Phe Ser His Arg Ser Glu Ile Phe Gly Thr Cys
        3715                3720                3725            
Gly Glu Glu Gln Lys Thr Val Leu Gln Glu Lys Thr Glu Ser Leu Ile
    3730                3735                3740                
Gln Gln Tyr Glu Ala Ile Ser Leu Leu Asn Ser Glu Arg Tyr Ala Arg
3745                3750                3755                3760
Leu Glu Arg Ala Gln Val Leu Val Asn Gln Phe Trp Glu Thr Tyr Glu
                3765                3770                3775    
Glu Leu Ser Pro Trp Ile Glu Glu Thr Arg Ala Leu Ile Ala Gln Leu
            3780                3785                3790        
Pro Ser Pro Ala Ile Asp His Glu Gln Leu Arg Gln Gln Gln Glu Glu
        3795                3800                3805            
Met Arg Gln Leu Arg Glu Ser Ile Ala Glu His Lys Pro His Ile Asp
    3810                3815                3820                
Lys Leu Leu Lys Ile Gly Pro Gln Leu Lys Glu Leu Asn Pro Glu Glu
3825                3830                3835                3840
Gly Glu Met Val Glu Glu Lys Tyr Gln Lys Ala Glu Asn Met Tyr Ala
                3845                3850                3855    
Gln Ile Lys Glu Glu Val Arg Gln Arg Ala Leu Ala Leu Asp Glu Ala
            3860                3865                3870        
Val Ser Gln Ser Thr Gln Ile Thr Glu Phe His Asp Lys Ile Glu Pro
        3875                3880                3885            
Met Leu Glu Thr Leu Glu Asn Leu Ser Ser Arg Leu Arg Met Pro Pro
    3890                3895                3900                
Leu Ile Pro Ala Glu Val Asp Lys Ile Arg Glu Cys Ile Ser Asp Asn
3905                3910                3915                3920
Lys Ser Ala Thr Val Glu Leu Glu Lys Leu Gln Pro Ser Phe Glu Ala
                3925                3930                3935    
Leu Lys Arg Arg Gly Glu Glu Leu Ile Gly Arg Ser Gln Gly Ala Asp
            3940                3945                3950        
Lys Asp Leu Ala Ala Lys Glu Ile Gln Asp Lys Leu Asp Gln Met Val
        3955                3960                3965            
Phe Phe Trp Glu Asp Ile Lys Ala Arg Ala Glu Glu Arg Glu Ile Lys
    3970                3975                3980                
Phe Leu Asp Val Leu Glu Leu Ala Glu Lys Phe Trp Tyr Asp Met Ala
3985                3990                3995                4000
Ala Leu Leu Thr Thr Ile Lys Asp Thr Gln Asp Ile Val His Asp Leu
                4005                4010                4015    
Glu Ser Pro Gly Ile Asp Pro Ser Ile Ile Lys Gln Gln Val Glu Ala
            4020                4025                4030        
Ala Glu Thr Ile Lys Glu Glu Thr Asp Gly Leu His Glu Glu Leu Glu
        4035                4040                4045            
Phe Ile Arg Ile Leu Gly Ala Asp Leu Ile Phe Ala Cys Gly Glu Thr
    4050                4055                4060                
Glu Lys Pro Glu Val Arg Lys Ser Ile Asp Glu Met Asn Asn Ala Trp
4065                4070                4075                4080
Glu Asn Leu Asn Lys Thr Trp Lys Glu Arg Leu Glu Lys Leu Glu Asp
                4085                4090                4095    
Ala Met Gln Ala Ala Val Gln Tyr Gln Asp Thr Leu Gln Ala Met Phe
            4100                4105                4110        
Asp Trp Leu Asp Asn Thr Val Ile Lys Leu Cys Thr Met Pro Pro Val
        4115                4120                4125            
Gly Thr Asp Leu Asn Thr Val Lys Asp Gln Leu Asn Glu Met Lys Glu
    4130                4135                4140                
Phe Lys Val Glu Val Tyr Gln Gln Gln Ile Glu Met Glu Lys Leu Asn
4145                4150                4155                4160
His Gln Gly Glu Leu Met Leu Lys Lys Ala Thr Asp Glu Thr Asp Arg
                4165                4170                4175    
Asp Ile Ile Arg Glu Pro Leu Thr Glu Leu Lys His Leu Trp Glu Asn
            4180                4185                4190        
Leu Gly Glu Lys Ile Ala His Arg Gln His Lys Leu Glu Gly Ala Leu
        4195                4200                4205            
Leu Ala Leu Gly Gln Phe Gln His Ala Leu Glu Glu Leu Met Ser Trp
    4210                4215                4220                
Leu Thr His Thr Glu Glu Leu Leu Asp Ala Gln Arg Pro Ile Ser Gly
4225                4230                4235                4240
Asp Pro Lys Val Ile Glu Val Glu Leu Ala Lys His His Val Leu Lys
                4245                4250                4255    
Asn Asp Val Leu Ala His Gln Ala Thr Val Glu Thr Val Asn Lys Ala
            4260                4265                4270        
Gly Asn Glu Leu Leu Glu Ser Ser Ala Gly Asp Asp Ala Ser Ser Leu
        4275                4280                4285            
Arg Ser Arg Leu Glu Ala Met Asn Gln Cys Trp Glu Ser Val Leu Gln
    4290                4295                4300                
Lys Thr Glu Glu Arg Glu Gln Gln Leu Gln Ser Thr Leu Gln Gln Ala
4305                4310                4315                4320
Gln Gly Phe His Ser Glu Ile Glu Asp Phe Leu Leu Glu Leu Thr Arg
                4325                4330                4335    
Met Glu Ser Gln Leu Ser Ala Ser Lys Pro Thr Gly Gly Leu Pro Glu
            4340                4345                4350        
Thr Ala Arg Glu Gln Leu Asp Thr His Met Glu Leu Tyr Ser Gln Leu
        4355                4360                4365            
Lys Ala Lys Glu Glu Thr Tyr Asn Gln Leu Leu Asp Lys Gly Arg Leu
    4370                4375                4380                
Met Leu Leu Ser Arg Asp Asp Ser Gly Ser Gly Ser Lys Thr Glu Gln
4385                4390                4395                4400
Ser Val Ala Leu Leu Glu Gln Lys Trp His Val Val Ser Ser Lys Met
                4405                4410                4415    
Glu Glu Arg Lys Ser Lys Leu Glu Glu Ala Leu Asn Leu Ala Thr Glu
            4420                4425                4430        
Phe Gln Asn Ser Leu Gln Glu Phe Ile Asn Trp Leu Thr Leu Ala Glu
        4435                4440                4445            
Gln Ser Leu Asn Ile Ala Ser Pro Pro Ser Leu Ile Leu Asn Thr Val
    4450                4455                4460                
Leu Ser Gln Ile Glu Glu His Lys Val Phe Ala Asn Glu Val Asn Ala
4465                4470                4475                4480
His Arg Asp Gln Ile Ile Glu Leu Asp Gln Thr Gly Asn Gln Leu Lys
                4485                4490                4495    
Phe Leu Ser Gln Lys Gln Asp Val Val Leu Ile Lys Asn Leu Leu Val
            4500                4505                4510        
Ser Val Gln Ser Arg Trp Glu Lys Val Val Gln Arg Ser Ile Glu Arg
        4515                4520                4525            
Gly Arg Ser Leu Asp Asp Ala Arg Lys Arg Ala Lys Gln Phe His Glu
    4530                4535                4540                
Ala Trp Lys Lys Leu Ile Asp Trp Leu Glu Asp Ala Glu Ser His Leu
4545                4550                4555                4560
Asp Ser Glu Leu Glu Ile Ser Asn Asp Pro Asp Lys Ile Lys Leu Gln
                4565                4570                4575    
Leu Ser Lys His Lys Glu Phe Gln Lys Thr Leu Gly Gly Lys Gln Pro
            4580                4585                4590        
Val Tyr Asp Thr Thr Ile Arg Thr Gly Arg Ala Leu Lys Glu Lys Thr
        4595                4600                4605            
Leu Leu Pro Glu Asp Thr Gln Lys Leu Asp Asn Phe Leu Gly Glu Val
    4610                4615                4620                
Arg Asp Lys Trp Asp Thr Val Cys Gly Lys Ser Val Glu Arg Gln His
4625                4630                4635                4640
Lys Leu Glu Glu Ala Leu Leu Phe Ser Gly Gln Phe Met Asp Ala Leu
                4645                4650                4655    
Gln Ala Leu Val Asp Trp Leu Tyr Lys Val Glu Pro Gln Leu Ala Glu
            4660                4665                4670        
Asp Gln Pro Val His Gly Asp Leu Asp Leu Val Met Asn Leu Met Asp
        4675                4680                4685            
Ala His Lys Val Phe Gln Lys Glu Leu Gly Lys Arg Thr Gly Thr Val
    4690                4695                4700                
Gln Val Leu Lys Arg Ser Gly Arg Glu Leu Ile Glu Asn Ser Arg Asp
4705                4710                4715                4720
Asp Thr Thr Trp Val Lys Gly Gln Leu Gln Glu Leu Ser Thr Arg Trp
                4725                4730                4735    
Asp Thr Val Cys Lys Leu Ser Val Ser Lys Gln Ser Arg Leu Glu Gln
            4740                4745                4750        
Ala Leu Lys Gln Ala Glu Val Phe Arg Asp Thr Val His Met Leu Leu
        4755                4760                4765            
Glu Trp Leu Ser Glu Ala Glu Gln Leu Arg Phe Arg Gly Ala Leu Pro
    4770                4775                4780                
Asp Asp Thr Glu Ala Leu Gln Ser Leu Ile Asp Thr His Lys Glu Phe
4785                4790                4795                4800
Met Lys Lys Val Glu Glu Lys Arg Val Asp Val Asn Ser Ala Val Ala
                4805                4810                4815    
Met Gly Glu Val Ile Leu Ala Val Cys His Pro Asp Cys Ile Thr Thr
            4820                4825                4830        
Ile Lys His Trp Ile Thr Ile Ile Arg Ala Arg Phe Glu Glu Val Leu
        4835                4840                4845            
Thr Trp Ala Lys Gln His Gln Gln Arg Leu Glu Thr Ala Leu Ser Glu
    4850                4855                4860                
Leu Val Ala Asn Ala Glu Leu Leu Glu Glu Leu Leu Ala Trp Ile Gln
4865                4870                4875                4880
Trp Ala Glu Thr Thr Leu Ile Gln Arg Asp Gln Glu Pro Ile Pro Gln
                4885                4890                4895    
Asn Ile Asp Arg Val Lys Ala Leu Ile Ala Glu His Gln Thr Phe Met
            4900                4905                4910        
Glu Glu Met Thr Arg Lys Gln Pro Asp Val Asp Arg Val Thr Lys Thr
        4915                4920                4925            
Tyr Lys Arg Lys Asn Ile Glu Pro Thr His Ala Pro Phe Ile Glu Lys
    4930                4935                4940                
Ser Arg Ser Gly Gly Arg Lys Ser Leu Ser Gln Pro Thr Pro Pro Pro
4945                4950                4955                4960
Met Pro Ile Leu Ser Gln Ser Glu Ala Lys Asn Pro Arg Ile Asn Gln
                4965                4970                4975    
Leu Ser Ala Arg Trp Gln Gln Val Trp Leu Leu Ala Leu Glu Arg Gln
            4980                4985                4990        
Arg Lys Leu Asn Asp Ala Leu Asp Arg Leu Glu Glu Leu Lys Glu Phe
        4995                5000                5005            
Ala Asn Phe Asp Phe Asp Val Trp Arg Lys Lys Tyr Met Arg Trp Met
    5010                5015                5020                
Asn His Lys Lys Ser Arg Val Met Asp Phe Phe Arg Arg Ile Asp Lys
5025                5030                5035                5040
Asp Gln Asp Gly Lys Ile Thr Arg Gln Glu Phe Ile Asp Gly Ile Leu
                5045                5050                5055    
Ala Ser Lys Phe Pro Thr Thr Lys Leu Glu Met Thr Ala Val Ala Asp
            5060                5065                5070        
Ile Phe Asp Arg Asp Gly Asp Gly Tyr Ile Asp Tyr Tyr Glu Phe Val
        5075                5080                5085            
Ala Ala Leu His Pro Asn Lys Asp Ala Tyr Arg Pro Thr Thr Asp Ala
    5090                5095                5100                
Asp Lys Ile Glu Asp Glu Val Thr Arg Gln Val Ala Gln Cys Lys Cys
5105                5110                5115                5120
Ala Lys Arg Phe Gln Val Glu Gln Ile Gly Glu Asn Lys Tyr Arg Phe
                5125                5130                5135    
Gly Asp Ser Gln Gln Leu Arg Leu Val Arg Ile Leu Arg Ser Thr Val
            5140                5145                5150        
Met Val Arg Val Gly Gly Gly Trp Met Ala Leu Asp Glu Phe Leu Val
        5155                5160                5165            
Lys Asn Asp Pro Cys Arg Ala Arg Gly Arg Thr Asn Ile Glu Leu Arg
    5170                5175                5180                
Glu Lys Phe Ile Leu Pro Glu Gly Ala Ser Gln Gly Met Thr Pro Phe
5185                5190                5195                5200
Arg Ser Arg Gly Arg Arg Ser Lys Pro Ser Ser Arg Ala Ala Ser Pro
                5205                5210                5215    
Thr Arg Ser Ser Ser Ser Ala Ser Gln Ser Asn His Ser Cys Thr Ser
            5220                5225                5230        
Met Pro Ser Ser Pro Ala Thr Pro Ala Ser Gly Thr Lys Val Ile Pro
        5235                5240                5245            
Ser Ser Gly Ser Lys Leu Lys Arg Pro Thr Pro Thr Phe His Ser Ser
    5250                5255                5260                
Arg Thr Ser Leu Ala Gly Asp Thr Ser Asn Ser Ser Ser Pro Ala Ser
5265                5270                5275                5280
Thr Gly Ala Lys Thr Asn Arg Ala Asp Pro Lys Lys Ser Ala Ser Arg
                5285                5290                5295    
Pro Gly Ser Arg Ala Gly Ser Arg Ala Gly Ser Arg Ala Ser Ser Arg
            5300                5305                5310        
Arg Gly Ser Asp Ala Ser Asp Phe Asp Leu Leu Glu Thr Gln Ser Ala
        5315                5320                5325            
Cys Ser Asp Thr Ser Glu Ser Ser Ala Ala Gly Gly Gln Gly Asn Ser
    5330                5335                5340                
Arg Arg Gly Leu Asn Lys Pro Ser Lys Ile Pro Thr Met Ser Lys Lys
5345                5350                5355                5360
Thr Thr Thr Ala Ser Pro Arg Thr Pro Gly Pro Lys Arg
                5365                5370            


<210> 742
<211> 179
<212> PRT
<213> Homo sapiens

<400> 742
Met Ala Phe Leu Ala Ser Gly Pro Tyr Leu Thr His Gln Gln Lys Val
 1               5                  10                  15      
Leu Arg Leu Tyr Lys Arg Ala Leu Arg His Leu Glu Ser Trp Cys Val
            20                  25                  30          
Gln Arg Asp Lys Tyr Arg Tyr Phe Ala Cys Leu Met Arg Ala Arg Phe
        35                  40                  45              
Glu Glu His Lys Asn Glu Lys Asp Met Ala Lys Ala Thr Gln Leu Leu
    50                  55                  60                  
Lys Glu Ala Glu Glu Glu Phe Trp Tyr Arg Gln His Pro Gln Pro Tyr
65                  70                  75                  80  
Ile Phe Pro Asp Ser Pro Gly Gly Thr Ser Tyr Glu Arg Tyr Asp Cys
                85                  90                  95      
Tyr Lys Val Pro Glu Trp Cys Leu Asp Asp Trp His Pro Ser Glu Lys
            100                 105                 110         
Ala Met Tyr Pro Asp Tyr Phe Ala Lys Arg Glu Gln Trp Lys Lys Leu
        115                 120                 125             
Arg Arg Glu Ser Trp Glu Arg Glu Val Lys Gln Leu Gln Glu Glu Thr
    130                 135                 140                 
Pro Pro Gly Gly Pro Leu Thr Glu Ala Leu Pro Pro Ala Arg Lys Glu
145                 150                 155                 160 
Gly Asp Leu Pro Pro Leu Trp Trp Tyr Ile Val Thr Arg Pro Arg Glu
                165                 170                 175     
Arg Pro Met
            


<210> 743
<211> 387
<212> PRT
<213> Homo sapiens

<400> 743
Met Ala Gly Ala Glu Trp Lys Ser Leu Glu Glu Cys Leu Glu Lys His
 1               5                  10                  15      
Leu Pro Leu Pro Asp Leu Gln Glu Val Lys Arg Val Leu Tyr Gly Lys
            20                  25                  30          
Glu Leu Arg Lys Leu Asp Leu Pro Arg Glu Ala Phe Glu Ala Ala Ser
        35                  40                  45              
Arg Glu Asp Phe Glu Leu Gln Gly Tyr Ala Phe Glu Ala Ala Glu Glu
    50                  55                  60                  
Gln Leu Arg Arg Pro Arg Ile Val His Val Gly Leu Val Gln Asn Arg
65                  70                  75                  80  
Ile Pro Leu Pro Ala Asn Ala Pro Val Ala Glu Gln Val Ser Ala Leu
                85                  90                  95      
His Arg Arg Ile Lys Ala Ile Val Glu Val Ala Ala Met Cys Gly Val
            100                 105                 110         
Asn Ile Ile Cys Phe Gln Glu Ala Trp Thr Met Pro Phe Ala Phe Cys
        115                 120                 125             
Thr Arg Glu Lys Leu Pro Trp Thr Glu Phe Ala Glu Ser Ala Glu Asp
    130                 135                 140                 
Gly Pro Thr Thr Arg Phe Cys Gln Lys Leu Ala Lys Asn His Asp Met
145                 150                 155                 160 
Val Val Val Ser Pro Ile Leu Glu Arg Asp Ser Glu His Gly Asp Val
                165                 170                 175     
Leu Trp Asn Thr Ala Val Val Ile Ser Asn Ser Gly Ala Val Leu Gly
            180                 185                 190         
Lys Thr Arg Lys Asn His Ile Pro Arg Val Gly Asp Phe Asn Glu Ser
        195                 200                 205             
Thr Tyr Tyr Met Glu Gly Asn Leu Gly His Pro Val Phe Gln Thr Gln
    210                 215                 220                 
Phe Gly Arg Ile Ala Val Asn Ile Cys Tyr Gly Arg His His Pro Leu
225                 230                 235                 240 
Asn Trp Leu Met Tyr Ser Ile Asn Gly Ala Glu Ile Ile Phe Asn Pro
                245                 250                 255     
Ser Ala Thr Ile Gly Ala Leu Arg Ser Leu Ser Glu Ser Leu Trp Pro
            260                 265                 270         
Ile Glu Ala Arg Asn Ala Ala Ile Ala Asn His Cys Phe Thr Cys Ala
        275                 280                 285             
Ile Asn Arg Val Gly Thr Glu His Phe Pro Asn Glu Phe Thr Ser Gly
    290                 295                 300                 
Asp Gly Lys Lys Ala His Gln Asp Phe Gly Tyr Phe Tyr Gly Ser Ser
305                 310                 315                 320 
Tyr Val Ala Ala Pro Asp Ser Ser Arg Thr Pro Gly Leu Ser Arg Ser
                325                 330                 335     
Arg Asp Gly Leu Leu Val Ala Lys Leu Asp Leu Asn Leu Cys Gln Gln
            340                 345                 350         
Val Asn Asp Val Trp Asn Phe Lys Met Thr Gly Arg Tyr Glu Met Tyr
        355                 360                 365             
Ala Arg Glu Leu Ala Glu Ala Val Lys Ser Asn Tyr Ser Pro Thr Ile
    370                 375                 380                 
Val Lys Glu
385         


<210> 744
<211> 1487
<212> PRT
<213> Homo sapiens

<400> 744
Ala Gly Arg Asn Ala Pro Gly Gly Leu His Arg Ala Val Cys Phe Arg
 1               5                  10                  15      
Arg Leu Arg Gly Ser Leu Gly Pro Cys Gly Gly Ala Ala Pro Arg Gly
            20                  25                  30          
Phe Ala Arg Ser Leu Thr Ser Pro Cys Ser Leu Ala Ala Ala Gly Gly
        35                  40                  45              
Ala Arg Ala Ala Ala Gly Asp Pro Glu Lys Gly Glu Glu Leu Asn Val
    50                  55                  60                  
Ile Met Ser Gly Ile Lys Arg Thr Ile Lys Glu Thr Asp Pro Asp Tyr
65                  70                  75                  80  
Glu Asp Val Ser Val Ala Leu Pro Asn Lys Arg His Lys Ala Ile Glu
                85                  90                  95      
Asn Ser Ala Arg Asp Ala Ala Val Gln Lys Ile Glu Thr Ile Ile Lys
            100                 105                 110         
Glu Gln Phe Ala Leu Glu Met Lys Asn Lys Glu His Glu Ile Glu Val
        115                 120                 125             
Ile Asp Gln Arg Leu Ile Glu Ala Arg Arg Met Met Asp Lys Leu Arg
    130                 135                 140                 
Ala Cys Ile Val Ala Asn Tyr Tyr Ala Ser Ala Gly Leu Leu Lys Val
145                 150                 155                 160 
Ser Glu Gly Ser Lys Thr Cys Asp Thr Met Val Phe Asn His Pro Ala
                165                 170                 175     
Ile Lys Lys Phe Leu Glu Ser Pro Ser Arg Ser Ser Ser Pro Ala Asn
            180                 185                 190         
Gln Arg Ala Glu Thr Pro Ser Ala Asn His Ser Glu Ser Asp Ser Leu
        195                 200                 205             
Ser Gln His Asn Asp Phe Leu Ser Asp Lys Asp Asn Asn Ser Asn Met
    210                 215                 220                 
Asp Ile Glu Glu Arg Leu Ser Asn Asn Met Glu Gln Arg Pro Ser Arg
225                 230                 235                 240 
Asn Thr Gly Arg Asp Thr Ser Arg Ile Thr Gly Ser His Lys Thr Glu
                245                 250                 255     
Gln Arg Asn Ala Asp Leu Thr Asp Glu Thr Ser Arg Leu Phe Val Lys
            260                 265                 270         
Lys Thr Ile Val Val Gly Asn Val Ser Lys Tyr Ile Pro Pro Asp Lys
        275                 280                 285             
Arg Glu Glu Asn Asp Gln Ser Thr His Lys Trp Met Val Tyr Val Arg
    290                 295                 300                 
Gly Ser Arg Arg Glu Pro Ser Ile Asn His Phe Val Lys Lys Val Trp
305                 310                 315                 320 
Phe Phe Leu His Pro Ser Tyr Lys Pro Asn Asp Leu Val Glu Val Arg
                325                 330                 335     
Glu Pro Pro Phe His Leu Thr Arg Arg Gly Trp Gly Glu Phe Pro Val
            340                 345                 350         
Arg Val Gln Val His Phe Lys Asp Ser Gln Asn Lys Arg Ile Asp Ile
        355                 360                 365             
Ile His Asn Leu Lys Leu Asp Arg Thr Tyr Thr Gly Leu Gln Thr Leu
    370                 375                 380                 
Gly Ala Glu Thr Val Val Asp Val Glu Leu His Arg His Ser Leu Gly
385                 390                 395                 400 
Glu Asp Cys Ile Tyr Pro Gln Ser Ser Glu Ser Asp Ile Ser Asp Ala
                405                 410                 415     
Pro Pro Ser Leu Pro Leu Thr Ile Pro Ala Pro Val Lys Ala Ser Ser
            420                 425                 430         
Pro Ile Lys Gln Ser His Glu Pro Val Pro Asp Thr Ser Val Glu Lys
        435                 440                 445             
Gly Phe Pro Ala Ser Thr Glu Ala Glu Arg His Thr Pro Phe Tyr Ala
    450                 455                 460                 
Leu Pro Ser Ser Leu Glu Arg Thr Pro Thr Lys Met Thr Thr Ser Gln
465                 470                 475                 480 
Lys Val Thr Phe Cys Ser His Gly Asn Ser Ala Phe Gln Pro Ile Ala
                485                 490                 495     
Ser Ser Cys Lys Ile Val Pro Gln Ser Gln Val Pro Asn Pro Glu Ser
            500                 505                 510         
Pro Gly Lys Ser Phe Gln Pro Ile Thr Met Ser Cys Lys Ile Val Ser
        515                 520                 525             
Gly Ser Pro Ile Ser Thr Pro Ser Pro Ser Pro Leu Pro Arg Thr Pro
    530                 535                 540                 
Thr Ser Thr Pro Val His Val Lys Gln Gly Thr Ala Gly Ser Val Ile
545                 550                 555                 560 
Asn Asn Pro Tyr Val Ile Met Asp Lys Gln Pro Gly Gln Val Ile Gly
                565                 570                 575     
Ala Thr Thr Pro Ser Thr Gly Ser Pro Thr Asn Lys Ile Ser Thr Ala
            580                 585                 590         
Ser Gln Val Ser Gln Gly Thr Gly Ser Pro Val Pro Lys Ile His Gly
        595                 600                 605             
Ser Ser Phe Val Thr Ser Thr Val Lys Gln Glu Asp Ser Leu Phe Ala
    610                 615                 620                 
Ser Met Pro Pro Leu Cys Pro Ile Gly Ser His Pro Lys Val Gln Ser
625                 630                 635                 640 
Pro Lys Pro Ile Thr Gly Gly Leu Gly Ala Phe Thr Lys Val Ile Ile
                645                 650                 655     
Lys Gln Glu Pro Gly Glu Ala Pro His Val Pro Ala Thr Gly Ala Ala
            660                 665                 670         
Ser Gln Ser Pro Leu Pro Gln Tyr Val Thr Val Lys Gly Gly His Met
        675                 680                 685             
Ile Ala Val Ser Pro Gln Lys Gln Val Ile Thr Pro Gly Glu Gly Ile
    690                 695                 700                 
Ala Gln Ser Ala Lys Val Gln Pro Ser Lys Val Val Gly Val Pro Val
705                 710                 715                 720 
Gly Ser Ala Leu Pro Ser Thr Val Lys Gln Ala Val Ala Ile Ser Gly
                725                 730                 735     
Gly Gln Ile Leu Val Ala Lys Ala Ser Ser Ser Val Ser Lys Ala Val
            740                 745                 750         
Gly Pro Lys Gln Val Val Thr Gln Gly Val Ala Lys Ala Ile Val Ser
        755                 760                 765             
Gly Gly Gly Gly Thr Ile Val Ala Gln Pro Val Gln Thr Leu Thr Lys
    770                 775                 780                 
Ala Gln Val Thr Ala Ala Gly Pro Gln Lys Ser Gly Ser Gln Gly Ser
785                 790                 795                 800 
Val Met Ala Thr Leu Gln Leu Pro Ala Thr Asn Leu Ala Asn Leu Ala
                805                 810                 815     
Asn Leu Pro Pro Gly Thr Lys Leu Tyr Leu Thr Thr Asn Ser Lys Asn
            820                 825                 830         
Pro Ser Gly Lys Gly Lys Leu Leu Leu Ile Pro Gln Gly Ala Ile Leu
        835                 840                 845             
Arg Ala Thr Asn Asn Ala Asn Leu Gln Ser Gly Ser Ala Ala Ser Gly
    850                 855                 860                 
Gly Ser Gly Ala Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser
865                 870                 875                 880 
Gly Ser Gly Gly Gly Gly Ser Thr Gly Gly Gly Gly Gly Thr Ala Gly
                885                 890                 895     
Gly Gly Thr Gln Ser Thr Ala Gly Pro Gly Gly Ile Ser Gln His Leu
            900                 905                 910         
Thr Tyr Thr Ser Tyr Ile Leu Lys Gln Thr Pro Gln Gly Thr Phe Leu
        915                 920                 925             
Val Gly Gln Pro Ser Pro Gln Thr Ser Gly Lys Gln Leu Thr Thr Gly
    930                 935                 940                 
Ser Val Val Gln Gly Thr Leu Gly Val Ser Thr Ser Ser Ala Gln Gly
945                 950                 955                 960 
Gln Gln Thr Leu Lys Val Ile Ser Gly Gln Lys Thr Thr Leu Phe Thr
                965                 970                 975     
Gln Ala Ala His Gly Gly Gln Ala Ser Leu Met Lys Ile Ser Asp Ser
            980                 985                 990         
Thr Leu Lys Thr Val Pro Ala Thr Ser Gln Leu Ser Lys Pro Gly Thr
        995                 1000                1005            
Thr Met Leu Arg Val Ala Gly Gly Val Ile Thr Thr Ala Thr Ser Pro
    1010                1015                1020                
Ala Val Ala Leu Ser Ala Asn Gly Pro Ala Gln Gln Ser Glu Gly Met
1025                1030                1035                1040
Ala Pro Val Ser Ser Ser Thr Val Ser Ser Val Thr Lys Thr Ser Gly
                1045                1050                1055    
Gln Gln Gln Val Cys Val Ser Gln Ala Thr Val Gly Thr Cys Lys Ala
            1060                1065                1070        
Ala Thr Pro Thr Val Val Ser Ala Thr Ser Leu Val Pro Thr Pro Asn
        1075                1080                1085            
Pro Ile Ser Gly Lys Ala Thr Val Ser Gly Leu Leu Lys Ile His Ser
    1090                1095                1100                
Ser Gln Ser Ser Pro Gln Gln Ala Val Leu Thr Ile Pro Ser Gln Leu
1105                1110                1115                1120
Lys Pro Leu Ser Val Asn Thr Ser Gly Gly Val Gln Thr Ile Leu Met
                1125                1130                1135    
Pro Val Asn Lys Val Val Gln Ser Phe Ser Thr Ser Lys Pro Pro Ala
            1140                1145                1150        
Ile Leu Pro Val Ala Ala Pro Thr Pro Val Val Pro Ser Ser Ala Pro
        1155                1160                1165            
Ala Ala Val Ala Lys Val Lys Thr Glu Pro Glu Thr Pro Gly Pro Ser
    1170                1175                1180                
Cys Leu Ser Gln Glu Gly Gln Thr Ala Val Lys Thr Glu Glu Ser Ser
1185                1190                1195                1200
Glu Leu Gly Asn Tyr Val Ile Lys Ile Asp His Leu Glu Thr Ile Gln
                1205                1210                1215    
Gln Leu Leu Thr Ala Val Val Lys Lys Ile Pro Leu Ile Thr Ala Lys
            1220                1225                1230        
Ser Glu Asp Ala Ser Cys Phe Ser Ala Lys Ser Val Glu Gln Tyr Tyr
        1235                1240                1245            
Gly Trp Asn Ile Gly Lys Arg Arg Ala Ala Glu Trp Gln Arg Ala Met
    1250                1255                1260                
Thr Met Arg Lys Val Leu Gln Glu Ile Leu Glu Lys Asn Pro Arg Phe
1265                1270                1275                1280
His His Leu Thr Pro Leu Lys Thr Lys His Ile Ala His Trp Cys Arg
                1285                1290                1295    
Cys His Gly Tyr Thr Pro Pro Asp Pro Glu Ser Leu Arg Asn Asp Gly
            1300                1305                1310        
Asp Ser Ile Glu Asp Val Leu Thr Gln Ile Asp Ser Glu Pro Glu Cys
        1315                1320                1325            
Pro Ser Ser Phe Ser Ser Ala Asp Asn Leu Cys Arg Lys Leu Glu Asp
    1330                1335                1340                
Leu Gln Gln Phe Gln Lys Arg Glu Pro Glu Asn Glu Glu Glu Val Asp
1345                1350                1355                1360
Ile Leu Ser Leu Ser Glu Pro Val Lys Ile Asn Ile Lys Lys Glu Gln
                1365                1370                1375    
Glu Glu Lys Gln Glu Glu Val Lys Phe Tyr Leu Pro Pro Thr Pro Gly
            1380                1385                1390        
Ser Glu Phe Ile Gly Asp Val Thr Gln Lys Ile Gly Ile Thr Leu Gln
        1395                1400                1405            
Pro Val Ala Leu His Arg Asn Val Tyr Ala Ser Val Val Glu Asp Met
    1410                1415                1420                
Ile Leu Lys Ala Thr Glu Gln Leu Val Asn Asp Ile Leu Arg Gln Ala
1425                1430                1435                1440
Leu Ala Val Gly Tyr Gln Thr Ala Ser His Asn Arg Ile Pro Lys Glu
                1445                1450                1455    
Ile Thr Val Ser Asn Ile His Gln Ala Ile Cys Asn Ile Pro Phe Leu
            1460                1465                1470        
Asp Phe Leu Thr Asn Lys His Met Gly Ile Leu Asn Glu Asp Gln
        1475                1480                1485        


<210> 745
<211> 1011
<212> PRT
<213> Homo sapiens

<400> 745
Gln Pro Pro Asp Leu Ala Ala Ala Arg Thr Arg Pro Ala Arg Pro Ala
 1               5                  10                  15      
Ala Arg Leu Leu Ala Ala His Asp Val Pro Val Phe Gly Trp Arg Ser
            20                  25                  30          
Arg Ser Ser Gly Pro Pro Ala Thr Phe Pro Ser Ser Lys Gly Gly Gly
        35                  40                  45              
Gly Ser Ser Tyr Met Glu Glu Met Tyr Phe Ala Trp Leu Glu Asn Pro
    50                  55                  60                  
Gln Ser Val His Lys Ser Trp Asp Ser Phe Phe Arg Glu Ala Ser Glu
65                  70                  75                  80  
Glu Ala Phe Ser Gly Ser Ala Gln Pro Arg Pro Pro Ser Val Val His
                85                  90                  95      
Glu Ser Arg Ser Ala Val Ser Ser Arg Thr Lys Thr Ser Lys Leu Val
            100                 105                 110         
Glu Asp His Leu Ala Val Gln Ser Leu Ile Arg Ala Tyr Gln Ile Arg
        115                 120                 125             
Gly His His Val Ala Gln Leu Asp Pro Leu Gly Ile Leu Asp Ala Asp
    130                 135                 140                 
Leu Asp Ser Phe Val Pro Ser Asp Leu Ile Thr Thr Ile Asp Lys Leu
145                 150                 155                 160 
Ala Phe Tyr Asp Leu Gln Glu Ala Asp Leu Asp Lys Glu Phe Gln Leu
                165                 170                 175     
Pro Thr Thr Thr Phe Ile Gly Gly Ser Glu Asn Thr Leu Ser Leu Arg
            180                 185                 190         
Glu Ile Ile Arg Arg Leu Glu Asn Thr Tyr Cys Gln His Ile Gly Leu
        195                 200                 205             
Glu Phe Met Phe Ile Asn Asp Val Glu Gln Cys Gln Trp Ile Arg Gln
    210                 215                 220                 
Lys Phe Glu Thr Pro Gly Val Met Gln Phe Ser Ser Glu Glu Lys Arg
225                 230                 235                 240 
Thr Leu Leu Ala Arg Leu Val Arg Ser Met Arg Phe Glu Asp Phe Leu
                245                 250                 255     
Ala Arg Lys Trp Ser Ser Glu Lys Arg Phe Gly Leu Glu Gly Cys Glu
            260                 265                 270         
Val Met Ile Pro Ala Leu Lys Thr Ile Ile Asp Lys Ser Ser Glu Met
        275                 280                 285             
Gly Ile Glu Asn Val Ile Leu Gly Met Pro His Arg Gly Arg Leu Asn
    290                 295                 300                 
Val Leu Ala Asn Val Ile Arg Lys Asp Leu Glu Gln Ile Phe Cys Gln
305                 310                 315                 320 
Phe Asp Pro Lys Leu Glu Ala Ala Asp Glu Gly Ser Gly Asp Val Lys
                325                 330                 335     
Tyr His Leu Gly Met Tyr His Glu Arg Ile Asn Arg Val Thr Asn Arg
            340                 345                 350         
Asn Ile Thr Leu Ser Leu Val Ala Asn Pro Ser His Leu Glu Ala Val
        355                 360                 365             
Asp Pro Val Val Gln Gly Lys Thr Lys Ala Glu Gln Phe Tyr Arg Gly
    370                 375                 380                 
Asp Ala Gln Gly Lys Lys Val Met Ser Ile Leu Val His Gly Asp Ala
385                 390                 395                 400 
Ala Phe Ala Gly Gln Gly Val Val Tyr Glu Thr Phe His Leu Ser Asp
                405                 410                 415     
Leu Pro Ser Tyr Thr Thr Asn Gly Thr Val His Val Val Val Asn Asn
            420                 425                 430         
Gln Ile Gly Phe Thr Thr Asp Pro Arg Met Ala Arg Ser Ser Pro Tyr
        435                 440                 445             
Pro Thr Asp Val Ala Arg Val Val Asn Ala Pro Ile Phe His Val Asn
    450                 455                 460                 
Ala Asp Asp Pro Glu Ala Val Ile Tyr Val Cys Ser Val Ala Ala Glu
465                 470                 475                 480 
Trp Arg Asn Thr Phe Asn Lys Asp Val Val Val Asp Leu Val Cys Tyr
                485                 490                 495     
Arg Arg Arg Gly His Asn Glu Met Asp Glu Pro Met Phe Thr Gln Pro
            500                 505                 510         
Leu Met Tyr Lys Gln Ile His Arg Gln Val Pro Val Leu Lys Lys Tyr
        515                 520                 525             
Ala Asp Lys Leu Ile Ala Glu Gly Thr Val Thr Leu Gln Glu Phe Glu
    530                 535                 540                 
Glu Glu Ile Ala Lys Tyr Asp Arg Ile Cys Glu Glu Ala Tyr Gly Arg
545                 550                 555                 560 
Ser Lys Asp Lys Lys Ile Leu His Ile Lys His Trp Leu Asp Ser Pro
                565                 570                 575     
Trp Pro Gly Phe Phe Asn Val Asp Gly Glu Pro Lys Ser Met Thr Cys
            580                 585                 590         
Pro Ala Thr Gly Ile Pro Glu Asp Met Leu Thr His Ile Gly Ser Val
        595                 600                 605             
Ala Ser Ser Val Pro Leu Glu Asp Phe Lys Ile His Thr Gly Leu Ser
    610                 615                 620                 
Arg Ile Leu Arg Gly Arg Ala Asp Met Thr Lys Asn Arg Thr Val Asp
625                 630                 635                 640 
Trp Ala Leu Ala Glu Tyr Met Ala Phe Gly Ser Leu Leu Lys Glu Gly
                645                 650                 655     
Ile His Val Arg Leu Ser Gly Gln Asp Val Glu Arg Gly Thr Phe Ser
            660                 665                 670         
His Arg His His Val Leu His Asp Gln Glu Val Asp Arg Arg Thr Cys
        675                 680                 685             
Val Pro Met Asn His Leu Trp Pro Asp Gln Ala Pro Tyr Thr Val Cys
    690                 695                 700                 
Asn Ser Ser Leu Ser Glu Tyr Gly Val Leu Gly Phe Glu Leu Gly Tyr
705                 710                 715                 720 
Ala Met Ala Ser Pro Asn Ala Leu Val Leu Trp Glu Ala Gln Phe Gly
                725                 730                 735     
Asp Phe His Asn Thr Ala Gln Cys Ile Ile Asp Gln Phe Ile Ser Thr
            740                 745                 750         
Gly Gln Ala Lys Trp Val Arg His Asn Gly Ile Val Leu Leu Leu Pro
        755                 760                 765             
His Gly Met Glu Gly Met Gly Pro Glu His Ser Ser Ala Arg Pro Glu
    770                 775                 780                 
Arg Phe Leu Gln Met Ser Asn Asp Asp Ser Asp Ala Tyr Pro Ala Phe
785                 790                 795                 800 
Thr Lys Asp Phe Glu Val Ser Gln Leu Tyr Asp Cys Asn Trp Ile Val
                805                 810                 815     
Val Asn Cys Ser Thr Pro Ala Asn Tyr Phe His Val Leu Arg Arg Gln
            820                 825                 830         
Ile Leu Leu Pro Phe Arg Lys Pro Leu Ile Ile Phe Thr Pro Lys Ser
        835                 840                 845             
Leu Leu Arg His Pro Glu Ala Lys Ser Ser Phe Asp Gln Met Val Ser
    850                 855                 860                 
Gly Thr Ser Phe Gln Arg Val Ile Pro Glu Asp Gly Ala Ala Ala Arg
865                 870                 875                 880 
Ala Pro Glu Gln Val Gln Arg Leu Ile Phe Cys Thr Gly Lys Val Tyr
                885                 890                 895     
Tyr Asp Leu Val Lys Glu Arg Ser Ser Gln Asp Leu Glu Glu Lys Val
            900                 905                 910         
Ala Ile Thr Arg Leu Glu Gln Ile Ser Pro Phe Pro Phe Asp Leu Ile
        915                 920                 925             
Lys Gln Glu Ala Glu Lys Tyr Pro Gly Ala Glu Leu Ala Trp Cys Gln
    930                 935                 940                 
Glu Glu His Lys Asn Met Gly Tyr Tyr Asp Tyr Ile Ser Pro Arg Phe
945                 950                 955                 960 
Met Thr Ile Leu Arg Arg Ala Arg Pro Ile Trp Tyr Val Gly Arg Asp
                965                 970                 975     
Pro Ala Ala Ala Pro Ala Thr Gly Asn Arg Asn Thr His Leu Val Ser
            980                 985                 990         
Leu Lys Lys Phe Leu Asp Thr Ala Phe Asn Leu Gln Ala Phe Glu Gly
        995                 1000                1005            
Lys Thr Phe
    1010    


<210> 746
<211> 1148
<212> PRT
<213> Homo sapiens

<400> 746
Met Gly Gln Gln Pro Gly Lys Val Leu Gly Asp Gln Arg Arg Pro Ser
 1               5                  10                  15      
Leu Pro Ala Leu His Phe Ile Lys Gly Ala Gly Lys Lys Glu Ser Ser
            20                  25                  30          
Arg His Gly Gly Pro His Cys Asn Val Phe Val Glu Gln Ala Leu Gln
        35                  40                  45              
Arg Pro Val Ala Ser Asp Phe Glu Pro Gln Gly Leu Ser Glu Ala Ala
    50                  55                  60                  
Arg Trp Asn Ser Lys Glu Asn Leu Leu Ala Gly Pro Ser Glu Asn Asp
65                  70                  75                  80  
Pro Asn Leu Phe Val Ala Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn
                85                  90                  95      
Thr Leu Ser Ile Thr Lys Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn
            100                 105                 110         
His Asn Gly Glu Trp Cys Glu Ala Gln Thr Lys Asn Gly Gln Gly Trp
        115                 120                 125             
Val Pro Ser Asn Tyr Ile Thr Pro Val Asn Ser Leu Glu Lys His Ser
    130                 135                 140                 
Trp Tyr His Gly Pro Val Ser Arg Asn Ala Ala Glu Tyr Pro Leu Ser
145                 150                 155                 160 
Ser Gly Ile Asn Gly Ser Phe Leu Val Arg Glu Ser Glu Ser Ser Pro
                165                 170                 175     
Ser Gln Arg Ser Ile Ser Leu Arg Tyr Glu Gly Arg Val Tyr His Tyr
            180                 185                 190         
Arg Ile Asn Thr Ala Ser Asp Gly Lys Leu Tyr Val Ser Ser Glu Ser
        195                 200                 205             
Arg Phe Asn Thr Leu Ala Glu Leu Val His His His Ser Thr Val Ala
    210                 215                 220                 
Asp Gly Leu Ile Thr Thr Leu His Tyr Pro Ala Pro Lys Arg Asn Lys
225                 230                 235                 240 
Pro Thr Val Tyr Gly Val Ser Pro Asn Tyr Asp Lys Trp Glu Met Glu
                245                 250                 255     
Arg Thr Asp Ile Thr Met Lys His Lys Leu Gly Gly Gly Gln Tyr Gly
            260                 265                 270         
Glu Val Tyr Glu Gly Val Trp Lys Lys Tyr Ser Leu Thr Val Ala Val
        275                 280                 285             
Lys Thr Leu Lys Glu Asp Thr Met Glu Val Glu Glu Phe Leu Lys Glu
    290                 295                 300                 
Ala Ala Val Met Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu
305                 310                 315                 320 
Gly Val Cys Thr Arg Glu Pro Pro Phe Tyr Ile Ile Thr Glu Phe Met
                325                 330                 335     
Thr Tyr Gly Asn Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Gln Glu
            340                 345                 350         
Val Asn Ala Val Val Leu Leu Tyr Met Ala Thr Gln Ile Ser Ser Ala
        355                 360                 365             
Met Glu Tyr Leu Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala
    370                 375                 380                 
Arg Asn Cys Leu Val Gly Glu Asn His Leu Val Lys Val Ala Asp Phe
385                 390                 395                 400 
Gly Leu Ser Arg Leu Met Thr Gly Asp Thr Tyr Thr Ala His Ala Gly
                405                 410                 415     
Ala Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ser Leu Ala Tyr Asn
            420                 425                 430         
Lys Phe Ser Ile Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp
        435                 440                 445             
Glu Ile Ala Thr Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Arg Ser
    450                 455                 460                 
Gln Val Tyr Glu Leu Leu Glu Lys Asp Tyr Arg Met Lys Arg Pro Glu
465                 470                 475                 480 
Gly Cys Pro Glu Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Gln Trp
                485                 490                 495     
Asn Pro Ser Asp Arg Pro Ser Phe Ala Glu Ile His Gln Ala Phe Glu
            500                 505                 510         
Thr Met Phe Gln Glu Ser Ser Ile Ser Asp Glu Val Glu Lys Glu Leu
        515                 520                 525             
Gly Lys Gln Gly Val Arg Gly Ala Val Thr Thr Leu Leu Gln Ala Pro
    530                 535                 540                 
Glu Leu Pro Thr Lys Thr Arg Thr Ser Arg Arg Ala Ala Glu His Arg
545                 550                 555                 560 
Asp Thr Thr Asp Val Pro Glu Met Pro His Ser Lys Gly Gln Gly Glu
                565                 570                 575     
Ser Asp Pro Leu Asp His Glu Pro Ala Val Ser Pro Leu Leu Pro Arg
            580                 585                 590         
Lys Glu Arg Gly Pro Pro Glu Gly Gly Leu Asn Glu Asp Glu Arg Leu
        595                 600                 605             
Leu Pro Lys Asp Lys Lys Thr Asn Leu Phe Ser Ala Leu Ile Lys Lys
    610                 615                 620                 
Lys Lys Lys Thr Ala Pro Thr Pro Pro Lys Arg Ser Ser Ser Phe Arg
625                 630                 635                 640 
Glu Met Asp Gly Gln Pro Glu Arg Arg Gly Ala Gly Glu Glu Glu Gly
                645                 650                 655     
Arg Asp Ile Ser Asn Gly Ala Leu Ala Phe Thr Pro Leu Asp Thr Ala
            660                 665                 670         
Asp Pro Ala Lys Ser Pro Lys Pro Ser Asn Gly Ala Gly Val Pro Asn
        675                 680                 685             
Gly Ala Leu Arg Glu Ser Gly Gly Ser Gly Phe Arg Ser Pro His Leu
    690                 695                 700                 
Trp Lys Lys Ser Ser Thr Leu Thr Ser Ser Arg Leu Ala Thr Gly Glu
705                 710                 715                 720 
Glu Glu Gly Gly Gly Ser Ser Ser Lys Arg Phe Leu Arg Ser Cys Ser
                725                 730                 735     
Val Ser Cys Val Pro His Gly Ala Lys Asp Thr Glu Trp Arg Ser Val
            740                 745                 750         
Thr Leu Pro Arg Asp Leu Gln Ser Thr Gly Arg Gln Phe Asp Ser Ser
        755                 760                 765             
Thr Phe Gly Gly His Lys Ser Glu Lys Pro Ala Leu Pro Arg Lys Arg
    770                 775                 780                 
Ala Gly Glu Asn Arg Ser Asp Gln Val Thr Arg Gly Thr Val Thr Pro
785                 790                 795                 800 
Pro Pro Arg Leu Val Lys Lys Asn Glu Glu Ala Ala Asp Glu Val Phe
                805                 810                 815     
Lys Asp Ile Met Glu Ser Ser Pro Gly Ser Ser Pro Pro Asn Leu Thr
            820                 825                 830         
Pro Lys Pro Leu Arg Arg Gln Val Thr Val Ala Pro Ala Ser Gly Leu
        835                 840                 845             
Pro His Lys Glu Glu Ala Trp Lys Gly Ser Ala Leu Gly Thr Pro Ala
    850                 855                 860                 
Ala Ala Glu Pro Val Thr Pro Thr Ser Lys Ala Gly Ser Gly Ala Pro
865                 870                 875                 880 
Arg Gly Thr Ser Lys Gly Pro Ala Glu Glu Ser Arg Val Arg Arg His
                885                 890                 895     
Lys His Ser Ser Glu Ser Pro Gly Arg Asp Lys Gly Lys Leu Ser Lys
            900                 905                 910         
Leu Lys Pro Ala Pro Pro Pro Pro Pro Ala Ala Ser Ala Gly Lys Ala
        915                 920                 925             
Gly Gly Lys Pro Ser Gln Arg Pro Gly Gln Glu Ala Ala Gly Glu Ala
    930                 935                 940                 
Val Leu Gly Ala Lys Thr Lys Ala Thr Ser Leu Val Asp Ala Val Asn
945                 950                 955                 960 
Ser Asp Ala Ala Lys Pro Ser Gln Pro Ala Glu Gly Leu Lys Lys Pro
                965                 970                 975     
Val Leu Pro Ala Thr Pro Lys Pro His Pro Ala Lys Pro Ser Gly Thr
            980                 985                 990         
Pro Ile Ser Pro Ala Pro Val Pro Leu Ser Thr Leu Pro Ser Ala Ser
        995                 1000                1005            
Ser Ala Leu Ala Gly Asp Gln Pro Ser Ser Thr Ala Phe Ile Pro Leu
    1010                1015                1020                
Ile Ser Thr Arg Val Ser Leu Arg Lys Thr Arg Gln Pro Pro Glu Arg
1025                1030                1035                1040
Ala Ser Gly Ala Ile Thr Lys Gly Val Val Leu Asp Ser Thr Glu Ala
                1045                1050                1055    
Leu Cys Leu Ala Ile Ser Gly Asn Ser Glu Gln Met Ala Ser His Ser
            1060                1065                1070        
Ala Val Leu Glu Ala Gly Lys Asn Leu Tyr Thr Phe Cys Val Ser Tyr
        1075                1080                1085            
Val Asp Ser Ile Gln Gln Met Arg Asn Lys Phe Ala Phe Arg Glu Ala
    1090                1095                1100                
Ile Asn Lys Leu Glu Asn Asn Leu Arg Glu Leu Gln Ile Cys Pro Ala
1105                1110                1115                1120
Ser Ala Gly Ser Gly Pro Ala Ala Thr Gln Asp Phe Ser Lys Leu Leu
                1125                1130                1135    
Ser Ser Val Lys Glu Ile Ser Asp Ile Val Gln Arg
            1140                1145            


<210> 747
<211> 1096
<212> PRT
<213> Homo sapiens

<400> 747
Met Glu Gln Pro Gly Ala Ala Ala Ser Gly Ala Gly Gly Gly Ser Glu
 1               5                  10                  15      
Glu Pro Gly Gly Gly Arg Ser Asn Lys Arg Ser Ala Gly Asn Arg Ala
            20                  25                  30          
Ala Asn Glu Glu Glu Thr Lys Asn Lys Pro Lys Leu Asn Ile Gln Ile
        35                  40                  45              
Lys Thr Leu Ala Asp Asp Val Arg Asp Arg Ile Thr Ser Phe Arg Lys
    50                  55                  60                  
Ser Thr Val Lys Lys Glu Lys Pro Leu Ile Gln His Pro Ile Asp Ser
65                  70                  75                  80  
Gln Val Ala Met Ser Glu Phe Pro Ala Ala Gln Pro Leu Tyr Asp Glu
                85                  90                  95      
Arg Ser Leu Asn Leu Ser Glu Lys Glu Val Leu Asp Leu Phe Glu Lys
            100                 105                 110         
Met Met Glu Asp Met Asn Leu Asn Glu Glu Lys Lys Ala Pro Leu Arg
        115                 120                 125             
Asn Lys Asp Phe Thr Thr Lys Arg Glu Met Val Val Gln Tyr Ile Ser
    130                 135                 140                 
Ala Thr Ala Lys Ser Gly Gly Leu Lys Asn Ser Lys His Glu Cys Thr
145                 150                 155                 160 
Leu Ser Ser Gln Glu Tyr Val His Glu Leu Arg Ser Gly Ile Ser Asp
                165                 170                 175     
Glu Lys Leu Leu Asn Cys Leu Glu Ser Leu Arg Val Ser Leu Thr Ser
            180                 185                 190         
Asn Pro Val Ser Trp Val Asn Asn Phe Gly His Glu Gly Leu Gly Leu
        195                 200                 205             
Leu Leu Asp Glu Leu Glu Lys Leu Leu Asp Lys Lys Gln Gln Glu Asn
    210                 215                 220                 
Ile Asp Lys Lys Asn Gln Tyr Lys Leu Ile Gln Cys Leu Lys Ala Phe
225                 230                 235                 240 
Met Asn Asn Lys Phe Gly Leu Gln Arg Ile Leu Gly Asp Glu Arg Ser
                245                 250                 255     
Leu Leu Leu Leu Ala Arg Ala Ile Asp Pro Lys Gln Pro Asn Met Met
            260                 265                 270         
Thr Glu Ile Val Lys Ile Leu Ser Ala Ile Cys Ile Val Gly Glu Glu
        275                 280                 285             
Asn Ile Leu Asp Lys Leu Leu Gly Ala Ile Thr Thr Ala Ala Glu Arg
    290                 295                 300                 
Asn Asn Arg Glu Arg Phe Ser Pro Ile Val Glu Gly Leu Glu Asn Gln
305                 310                 315                 320 
Glu Ala Leu Gln Leu Gln Val Ala Cys Met Gln Phe Ile Asn Ala Leu
                325                 330                 335     
Val Thr Ser Pro Tyr Glu Leu Asp Phe Arg Ile His Leu Arg Asn Glu
            340                 345                 350         
Phe Leu Arg Ser Gly Leu Lys Thr Met Leu Pro Asp Leu Lys Glu Lys
        355                 360                 365             
Glu Asn Asp Glu Leu Asp Ile Gln Leu Lys Val Phe Asp Glu Asn Lys
    370                 375                 380                 
Glu Asp Asp Leu Thr Glu Leu Ser His Arg Leu Asn Asp Ile Arg Ala
385                 390                 395                 400 
Glu Met Asp Asp Met Asn Glu Val Tyr His Leu Leu Tyr Asn Met Leu
                405                 410                 415     
Lys Asp Thr Ala Ala Glu Asn Tyr Phe Leu Ser Ile Leu Gln His Phe
            420                 425                 430         
Leu Leu Ile Arg Asn Asp Tyr Tyr Ile Arg Pro Gln Tyr Tyr Lys Ile
        435                 440                 445             
Ile Glu Glu Cys Val Ser Gln Ile Val Leu His Cys Ser Gly Met Asp
    450                 455                 460                 
Pro Asp Phe Lys Tyr Arg Gln Arg Leu Asp Ile Asp Leu Thr His Leu
465                 470                 475                 480 
Ile Asp Ser Cys Val Asn Lys Ala Lys Val Glu Glu Ser Glu Gln Lys
                485                 490                 495     
Ala Ala Glu Phe Ser Lys Lys Phe Asp Glu Glu Phe Thr Ala Arg Gln
            500                 505                 510         
Glu Ala Gln Ala Glu Leu Gln Lys Arg Asp Glu Lys Ile Lys Glu Leu
        515                 520                 525             
Glu Ala Glu Ile Gln Gln Leu Arg Thr Gln Ala Gln Val Leu Ser Ser
    530                 535                 540                 
Ser Ser Gly Ile Pro Gly Pro Pro Ala Ala Pro Pro Leu Pro Gly Val
545                 550                 555                 560 
Gly Pro Pro Pro Pro Pro Pro Ala Pro Pro Leu Pro Gly Gly Ala Pro
                565                 570                 575     
Leu Pro Pro Pro Pro Pro Pro Leu Pro Gly Met Met Gly Ile Pro Pro
            580                 585                 590         
Pro Pro Pro Pro Pro Leu Leu Phe Gly Gly Pro Pro Pro Pro Pro Pro
        595                 600                 605             
Leu Gly Gly Val Pro Pro Pro Pro Gly Ile Ser Leu Asn Leu Pro Tyr
    610                 615                 620                 
Gly Met Lys Gln Lys Lys Met Tyr Lys Pro Glu Val Ser Met Lys Arg
625                 630                 635                 640 
Ile Asn Trp Ser Lys Ile Glu Pro Thr Glu Leu Ser Glu Asn Cys Phe
                645                 650                 655     
Trp Leu Arg Val Lys Glu Asp Lys Phe Glu Asn Pro Asp Leu Phe Ala
            660                 665                 670         
Lys Leu Ala Leu Asn Phe Ala Thr Gln Ile Lys Val Gln Lys Asn Ala
        675                 680                 685             
Glu Ala Leu Glu Glu Lys Lys Thr Gly Pro Thr Lys Lys Lys Val Lys
    690                 695                 700                 
Glu Leu Arg Ile Leu Asp Pro Lys Thr Ala Gln Asn Leu Ser Ile Phe
705                 710                 715                 720 
Leu Gly Ser Tyr Arg Met Pro Tyr Glu Asp Ile Arg Asn Val Ile Leu
                725                 730                 735     
Glu Val Asn Glu Asp Met Leu Ser Glu Ala Leu Ile Gln Asn Leu Val
            740                 745                 750         
Lys His Leu Pro Glu Gln Lys Ile Leu Asn Glu Leu Ala Glu Leu Lys
        755                 760                 765             
Asn Glu Tyr Asp Asp Leu Cys Glu Pro Glu Gln Phe Gly Val Val Met
    770                 775                 780                 
Ser Ser Val Lys Met Leu Gln Pro Arg Leu Ser Ser Ile Leu Phe Lys
785                 790                 795                 800 
Leu Thr Phe Glu Glu His Ile Asn Asn Ile Lys Pro Ser Ile Ile Ala
                805                 810                 815     
Val Thr Leu Ala Cys Glu Glu Leu Lys Lys Ser Glu Ser Phe Asn Arg
            820                 825                 830         
Leu Leu Glu Leu Val Leu Leu Val Gly Asn Tyr Met Asn Ser Gly Ser
        835                 840                 845             
Arg Asn Ala Gln Ser Leu Gly Phe Lys Ile Asn Phe Leu Cys Lys Ile
    850                 855                 860                 
Arg Asp Thr Lys Ser Ala Asp Gln Lys Thr Thr Leu Leu His Phe Ile
865                 870                 875                 880 
Ala Asp Ile Cys Glu Glu Lys Tyr Arg Asp Ile Leu Lys Phe Pro Glu
                885                 890                 895     
Glu Leu Glu His Val Glu Ser Ala Ser Lys Val Ser Ala Gln Ile Leu
            900                 905                 910         
Lys Ser Asn Leu Ala Ser Met Glu Gln Gln Ile Val His Leu Glu Arg
        915                 920                 925             
Asp Ile Lys Lys Phe Pro Gln Ala Glu Asn Gln His Asp Lys Phe Val
    930                 935                 940                 
Glu Lys Met Thr Ser Phe Thr Lys Thr Ala Arg Glu Gln Tyr Glu Lys
945                 950                 955                 960 
Leu Ser Thr Met His Asn Asn Met Met Lys Leu Tyr Glu Asn Leu Gly
                965                 970                 975     
Glu Tyr Phe Ile Phe Asp Ser Lys Thr Val Ser Ile Glu Glu Phe Phe
            980                 985                 990         
Gly Asp Leu Asn Asn Phe Arg Thr Leu Phe Leu Glu Ala Val Arg Glu
        995                 1000                1005            
Asn Asn Lys Arg Arg Glu Met Glu Glu Lys Thr Arg Arg Ala Lys Leu
    1010                1015                1020                
Ala Lys Glu Lys Ala Glu Gln Glu Lys Leu Glu Arg Gln Lys Lys Lys
1025                1030                1035                1040
Lys Gln Leu Ile Asp Ile Asn Lys Glu Gly Asp Glu Thr Gly Val Met
                1045                1050                1055    
Asp Asn Leu Leu Glu Ala Leu Gln Ser Gly Ala Ala Phe Arg Asp Arg
            1060                1065                1070        
Arg Lys Arg Ile Pro Arg Asn Pro Val Val Asn His Pro Cys Ala Thr
        1075                1080                1085            
Arg Ala Asn Pro Arg Ser Ala Thr
    1090                1095    


<210> 748
<211> 759
<212> PRT
<213> Homo sapiens

<400> 748
Ile Pro Ala Gly Met Glu Ala Asp Leu Ser Gln Leu Ser Glu Glu Glu
 1               5                  10                  15      
Arg Arg Gln Ile Ala Ala Val Met Ser Arg Ala Gln Gly Leu Pro Lys
            20                  25                  30          
Gly Ser Val Pro Pro Ala Ala Ala Glu Ser Pro Ser Met His Arg Lys
        35                  40                  45              
Gln Glu Leu Asp Ser Ser His Pro Pro Lys Gln Ser Gly Arg Pro Pro
    50                  55                  60                  
Asp Pro Gly Arg Pro Ala Gln Pro Gly Leu Ser Lys Ser Arg Thr Thr
65                  70                  75                  80  
Asp Thr Phe Arg Ser Glu Gln Lys Leu Pro Gly Arg Ser Pro Ser Thr
                85                  90                  95      
Ile Ser Leu Lys Glu Ser Lys Ser Arg Thr Asp Leu Lys Glu Glu His
            100                 105                 110         
Lys Ser Ser Met Met Pro Gly Phe Leu Ser Glu Val Asn Ala Leu Ser
        115                 120                 125             
Ala Val Ser Ser Val Val Asn Lys Phe Asn Pro Phe Asp Leu Ile Ser
    130                 135                 140                 
Asp Ser Glu Ala Ser Gln Glu Glu Thr Thr Lys Lys Gln Lys Val Val
145                 150                 155                 160 
Gln Lys Glu Gln Gly Lys Pro Glu Gly Ile Ile Lys Pro Pro Leu Gln
                165                 170                 175     
Gln Gln Pro Pro Lys Pro Ile Pro Lys Gln Gln Gly Pro Gly Arg Asp
            180                 185                 190         
Pro Leu Gln Gln Asp Gly Thr Pro Lys Ser Ile Ser Ser Gln Gln Pro
        195                 200                 205             
Glu Lys Ile Lys Ser Gln Pro Pro Gly Thr Gly Lys Pro Ile Gln Gly
    210                 215                 220                 
Pro Thr Gln Thr Pro Gln Thr Asp His Ala Lys Leu Pro Leu Gln Arg
225                 230                 235                 240 
Asp Ala Ser Arg Pro Gln Thr Lys Gln Ala Asp Ile Val Arg Gly Glu
                245                 250                 255     
Ser Val Lys Pro Ser Leu Pro Ser Pro Ser Lys Pro Pro Ile Gln Gln
            260                 265                 270         
Pro Thr Pro Gly Lys Pro Pro Ala Gln Gln Pro Gly His Glu Lys Ser
        275                 280                 285             
Gln Pro Gly Pro Ala Lys Pro Pro Ala Gln Pro Ser Gly Leu Thr Lys
    290                 295                 300                 
Pro Leu Ala Gln Gln Pro Gly Thr Val Lys Pro Pro Val Gln Pro Pro
305                 310                 315                 320 
Gly Thr Thr Lys Pro Pro Ala Gln Pro Leu Gly Pro Ala Lys Pro Pro
                325                 330                 335     
Ala Gln Gln Thr Gly Ser Glu Lys Pro Ser Ser Glu Gln Pro Gly Pro
            340                 345                 350         
Lys Ala Leu Ala Gln Pro Pro Gly Val Gly Lys Thr Pro Ala Gln Gln
        355                 360                 365             
Pro Gly Pro Ala Lys Pro Pro Thr Gln Gln Val Gly Thr Pro Lys Pro
    370                 375                 380                 
Leu Ala Gln Gln Pro Gly Leu Gln Ser Pro Ala Lys Ala Pro Gly Pro
385                 390                 395                 400 
Thr Lys Thr Pro Ala Gln Thr Lys Pro Pro Ser Gln Gln Pro Gly Ser
                405                 410                 415     
Thr Lys Pro Pro Pro Gln Gln Pro Gly Pro Ala Lys Pro Ser Pro Gln
            420                 425                 430         
Gln Pro Gly Ser Thr Lys Pro Pro Ser Gln Gln Pro Gly Ser Ala Lys
        435                 440                 445             
Pro Ser Ala Gln Gln Pro Ser Pro Ala Lys Pro Ser Ala Gln Gln Phe
    450                 455                 460                 
Thr Lys Pro Val Ser Gln Thr Gly Phe Gly Lys Pro Leu Gln Pro Pro
465                 470                 475                 480 
Thr Val Ser Pro Ser Ala Lys Gln Pro Pro Ser Gln Gly Leu Pro Lys
                485                 490                 495     
Thr Ile Cys Pro Leu Cys Asn Thr Thr Glu Leu Leu Leu His Val Pro
            500                 505                 510         
Glu Lys Ala Asn Phe Asn Thr Cys Thr Glu Cys Gln Thr Thr Val Cys
        515                 520                 525             
Ser Leu Cys Gly Phe Asn Pro Asn Pro His Leu Thr Glu Ala Lys Glu
    530                 535                 540                 
Trp Leu Cys Leu Asn Cys Gln Met Lys Arg Ala Leu Gly Gly Asp Leu
545                 550                 555                 560 
Ala Pro Val Pro Ser Ser Pro Gln Pro Lys Leu Lys Thr Ala Pro Val
                565                 570                 575     
Thr Thr Thr Ser Ala Val Ser Lys Ser Ser Pro Gln Pro Gln Gln Thr
            580                 585                 590         
Ser Pro Lys Lys Asp Ala Ala Pro Lys Gln Asp Leu Ser Lys Ala Pro
        595                 600                 605             
Glu Pro Lys Lys Pro Pro Pro Leu Val Lys Gln Pro Thr Leu His Gly
    610                 615                 620                 
Ser Pro Ser Ala Lys Ala Lys Gln Pro Pro Glu Ala Asp Ser Leu Ser
625                 630                 635                 640 
Lys Pro Ala Pro Pro Lys Glu Pro Ser Val Pro Ser Glu Gln Asp Lys
                645                 650                 655     
Ala Pro Val Ala Asp Asp Lys Pro Lys Gln Pro Lys Met Val Lys Pro
            660                 665                 670         
Thr Thr Asp Leu Val Ser Ser Ser Ser Ala Thr Thr Lys Pro Asp Ile
        675                 680                 685             
Pro Ser Ser Lys Val Gln Ser Gln Ala Glu Glu Lys Thr Thr Pro Pro
    690                 695                 700                 
Leu Lys Thr Asp Ser Ala Lys Pro Ser Gln Ser Phe Pro Pro Thr Gly
705                 710                 715                 720 
Glu Lys Val Thr Pro Phe Asp Ser Lys Ala Ile Pro Arg Pro Ala Ser
                725                 730                 735     
Asp Ser Lys Ile Ile Ser His Pro Gly Pro Ser Ser Glu Ser Lys Gly
            740                 745                 750         
Gln Lys Gln Val Asp Pro Val
        755                 


<210> 749
<211> 410
<212> PRT
<213> Homo sapiens

<400> 749
Met Ser Leu Ser Asn Lys Leu Thr Leu Asp Lys Leu Asp Val Lys Gly
 1               5                  10                  15      
Lys Arg Val Val Met Arg Val Asp Phe Asn Val Pro Met Lys Asn Asn
            20                  25                  30          
Gln Ile Thr Asn Asn Gln Arg Ile Lys Ala Ala Val Pro Ser Ile Lys
        35                  40                  45              
Phe Cys Leu Asp Asn Gly Ala Lys Ser Val Val Leu Met Ser His Leu
    50                  55                  60                  
Gly Arg Pro Asp Gly Val Pro Met Pro Asp Lys Tyr Ser Leu Glu Pro
65                  70                  75                  80  
Val Ala Val Glu Leu Lys Ser Leu Leu Gly Lys Asp Val Leu Phe Leu
                85                  90                  95      
Lys Asp Cys Val Gly Pro Glu Val Glu Lys Ala Cys Ala Asn Pro Ala
            100                 105                 110         
Ala Gly Ser Val Ile Leu Leu Glu Asn Leu Arg Phe His Val Glu Glu
        115                 120                 125             
Glu Gly Lys Gly Lys Asp Ala Ser Gly Asn Lys Val Lys Ala Glu Pro
    130                 135                 140                 
Ala Lys Ile Glu Ala Phe Arg Ala Ser Leu Ser Lys Leu Gly Asp Val
145                 150                 155                 160 
Tyr Val Asn Asp Ala Phe Gly Thr Ala His Arg Ala His Ser Ser Met
                165                 170                 175     
Val Gly Val Asn Leu Pro Gln Lys Ala Gly Gly Phe Leu Met Lys Lys
            180                 185                 190         
Glu Leu Asn Tyr Phe Ala Lys Ala Leu Glu Ser Pro Glu Arg Pro Phe
        195                 200                 205             
Leu Ala Ile Leu Gly Gly Ala Lys Val Ala Asp Lys Ile Gln Leu Ile
    210                 215                 220                 
Asn Asn Met Leu Asp Lys Val Asn Glu Met Ile Ile Gly Gly Gly Met
225                 230                 235                 240 
Ala Phe Thr Phe Leu Lys Val Leu Asn Asn Met Glu Ile Gly Thr Ser
                245                 250                 255     
Leu Phe Asp Glu Glu Gly Ala Lys Ile Val Lys Asp Leu Met Ser Lys
            260                 265                 270         
Ala Glu Lys Asn Gly Val Lys Ile Thr Leu Pro Val Asp Phe Val Thr
        275                 280                 285             
Ala Asp Lys Phe Asp Glu Asn Ala Lys Thr Gly Gln Ala Thr Val Ala
    290                 295                 300                 
Ser Gly Ile Pro Ala Gly Trp Met Gly Leu Asp Cys Gly Pro Glu Ser
305                 310                 315                 320 
Ser Lys Lys Tyr Ala Glu Ala Val Thr Arg Ala Lys Gln Ile Val Trp
                325                 330                 335     
Asn Gly Pro Val Gly Val Phe Glu Trp Glu Ala Phe Ala Arg Gly Thr
            340                 345                 350         
Lys Ala Leu Met Asp Glu Val Val Lys Ala Thr Ser Arg Gly Cys Ile
        355                 360                 365             
Thr Ile Ile Gly Gly Gly Asp Thr Ala Thr Cys Cys Ala Lys Trp Asn
    370                 375                 380                 
Thr Glu Asp Lys Val Ser His Val Ser Thr Gly Gly Gly Ala Ser Leu
385                 390                 395                 400 
Glu Leu Leu Glu Val Pro Val His Ser Pro
                405                 410 


<210> 750
<211> 229
<212> PRT
<213> Homo sapiens

<400> 750
Met Thr Thr Ala Ala Arg Pro Thr Phe Glu Pro Ala Arg Gly Gly Arg
 1               5                  10                  15      
Gly Lys Gly Glu Gly Asp Leu Ser Gln Leu Ser Lys Gln Tyr Ser Ser
            20                  25                  30          
Arg Asp Leu Pro Ser His Thr Lys Ile Lys Tyr Arg Gln Thr Thr Gln
        35                  40                  45              
Asp Ala Pro Glu Glu Val Arg Asn Arg Asp Phe Arg Arg Glu Leu Glu
    50                  55                  60                  
Glu Arg Glu Arg Ala Ala Ala Arg Glu Lys Asn Arg Asp Arg Pro Thr
65                  70                  75                  80  
Arg Glu His Thr Thr Ser Ser Ser Val Ser Lys Lys Pro Arg Leu Asp
                85                  90                  95      
Gln Ile Pro Ala Ala Asn Leu Asp Ala Asp Asp Pro Leu Thr Asp Glu
            100                 105                 110         
Glu Asp Glu Asp Phe Glu Glu Glu Ser Asp Asp Asp Asp Thr Ala Ala
        115                 120                 125             
Leu Leu Ala Glu Leu Glu Lys Ile Lys Lys Glu Arg Ala Glu Glu Gln
    130                 135                 140                 
Ala Arg Lys Glu Gln Glu Gln Lys Ala Glu Glu Glu Arg Ile Arg Met
145                 150                 155                 160 
Glu Asn Ile Leu Ser Gly Asn Pro Leu Leu Asn Leu Thr Gly Pro Ser
                165                 170                 175     
Gln Pro Gln Ala Asn Phe Lys Val Lys Arg Arg Trp Asp Asp Asp Val
            180                 185                 190         
Val Phe Lys Asn Cys Ala Lys Gly Val Asp Asp Gln Lys Lys Asp Lys
        195                 200                 205             
Arg Phe Val Asn Asp Thr Leu Arg Ser Glu Phe His Lys Lys Phe Met
    210                 215                 220                 
Glu Lys Tyr Ile Lys
225                 


<210> 751
<211> 268
<212> PRT
<213> Homo sapiens

<400> 751
Arg Ser Gly Pro Phe Ala Pro Val Leu Ser Ala Thr Ser Arg Gly Val
 1               5                  10                  15      
Ala Gly Ala Leu Arg Pro Leu Val Gln Ala Thr Val Pro Ala Thr Pro
            20                  25                  30          
Glu Gln Pro Val Leu Asp Leu Lys Arg Pro Phe Leu Ser Arg Glu Ser
        35                  40                  45              
Leu Ser Gly Gln Ala Val Arg Arg Pro Leu Val Ala Ser Val Gly Leu
    50                  55                  60                  
Asn Val Pro Ala Ser Val Cys Tyr Ser His Thr Asp Val Lys Val Pro
65                  70                  75                  80  
Asp Phe Ser Glu Tyr Arg Arg Leu Glu Val Leu Asp Ser Thr Lys Ser
                85                  90                  95      
Ser Arg Glu Ser Thr Glu Ala Arg Lys Gly Phe Ser Tyr Leu Val Thr
            100                 105                 110         
Gly Val Thr Thr Val Gly Val Ala Tyr Ala Ala Lys Asn Ala Val Thr
        115                 120                 125             
Gln Phe Val Ser Ser Met Ser Ala Ser Ala Asp Val Leu Ala Leu Ala
    130                 135                 140                 
Lys Ile Glu Ile Lys Leu Ser Asp Ile Pro Glu Gly Lys Asn Met Ala
145                 150                 155                 160 
Phe Lys Trp Arg Gly Lys Pro Leu Phe Val Arg His Arg Thr Gln Lys
                165                 170                 175     
Glu Ile Lys Gln Glu Ala Ala Val Glu Leu Ser Gln Leu Arg Asp Pro
            180                 185                 190         
Gln His Asp Leu Asp Arg Val Lys Lys Pro Glu Trp Val Ile Leu Ile
        195                 200                 205             
Gly Val Cys Thr His Leu Gly Cys Val Pro Ile Ala Asn Ala Gly Asp
    210                 215                 220                 
Phe Gly Gly Tyr Tyr Cys Pro Cys His Gly Ser His Tyr Asp Ala Ser
225                 230                 235                 240 
Gly Arg Ile Arg Leu Gly Pro Ala Thr Leu Asn Leu Glu Val Pro Thr
                245                 250                 255     
Tyr Glu Phe Thr Ser Asp Asp Met Val Ile Val Gly
            260                 265             


<210> 752
<211> 231
<212> PRT
<213> Homo sapiens

<400> 752
Glu Asn Val Ala Asn Ile Tyr Lys Asp Leu Gln Lys Leu Ser Arg Leu
 1               5                  10                  15      
Phe Lys Asp Gln Leu Val Tyr Pro Leu Leu Ala Phe Thr Arg Gln Ala
            20                  25                  30          
Leu Asn Leu Pro Asp Val Phe Gly Leu Val Val Leu Pro Leu Glu Leu
        35                  40                  45              
Lys Leu Arg Ile Phe Arg Leu Leu Asp Val Arg Ser Val Leu Ser Leu
    50                  55                  60                  
Ser Ala Val Cys Arg Asp Leu Phe Thr Ala Ser Asn Asp Pro Leu Leu
65                  70                  75                  80  
Trp Arg Phe Leu Tyr Leu Arg Asp Phe Arg Asp Asn Thr Val Arg Val
                85                  90                  95      
Gln Asp Thr Asp Trp Lys Glu Leu Tyr Arg Lys Arg His Ile Gln Arg
            100                 105                 110         
Lys Glu Ser Pro Lys Gly Arg Phe Val Met Leu Leu Pro Ser Ser Thr
        115                 120                 125             
His Thr Ile Pro Phe Tyr Pro Asn Pro Leu His Pro Arg Pro Phe Pro
    130                 135                 140                 
Ser Ser Arg Leu Pro Pro Gly Ile Ile Gly Gly Glu Tyr Asp Gln Arg
145                 150                 155                 160 
Pro Thr Leu Pro Tyr Val Gly Asp Pro Ile Ser Ser Leu Ile Pro Gly
                165                 170                 175     
Pro Gly Glu Thr Pro Ser Gln Phe Pro Pro Leu Arg Pro Arg Phe Asp
            180                 185                 190         
Pro Val Gly Pro Leu Pro Gly Pro Asn Pro Ile Leu Pro Gly Arg Gly
        195                 200                 205             
Gly Pro Asn Asp Arg Phe Pro Phe Arg Pro Ser Arg Gly Arg Pro Thr
    210                 215                 220                 
Asp Gly Arg Leu Ser Phe Met
225                 230     


<210> 753
<211> 176
<212> PRT
<213> Homo sapiens

<400> 753
His Pro Val Arg Arg Val Pro Ala Ala Ala Ala Ala Ser Pro Ala Gly
 1               5                  10                  15      
Ala Asp Arg Thr Lys Pro Asn Arg Ala Gly Ala Ala Gly Ala Ala Gly
            20                  25                  30          
Pro Pro Trp Thr Thr Ser Arg Cys Cys Arg Ser Gly Arg Pro Pro Thr
        35                  40                  45              
Thr Trp Arg Pro Ala Arg Arg Leu Leu Val Arg Pro Ala Arg Leu Arg
    50                  55                  60                  
Arg His Pro Arg Arg Ala Pro Ala Ala Ala Leu Pro Leu Pro Arg His
65                  70                  75                  80  
Arg Asp Thr His Pro Pro Ser Gln Gly Leu Gln His Pro Gln Pro Asp
                85                  90                  95      
Arg His Pro Leu Ser Cys Gln Leu Tyr Arg Gly Arg Arg Arg Leu Ser
            100                 105                 110         
Cys Leu Gln Gly Trp Gly Ala Gly Gly Leu Leu His Leu Pro Gly His
        115                 120                 125             
Leu Pro Gly His His Pro Leu Pro Leu Trp Val His Leu Leu Phe Cys
    130                 135                 140                 
Leu Glu Glu Ala Thr Met Pro Gln Leu Trp Ser His Leu Arg Leu Lys
145                 150                 155                 160 
Gly Thr Pro Gly Pro Gly Phe Pro Thr Pro Ser Ser Leu Phe Leu Met
                165                 170                 175     


<210> 754
<211> 445
<212> PRT
<213> Homo sapiens

<400> 754
Met Asn Glu Glu Tyr Asp Val Ile Val Leu Gly Thr Gly Leu Thr Glu
 1               5                  10                  15      
Cys Ile Leu Ser Gly Ile Met Ser Val Asn Gly Lys Lys Val Leu His
            20                  25                  30          
Met Asp Arg Asn Pro Tyr Tyr Gly Gly Glu Ser Ala Ser Ile Thr Pro
        35                  40                  45              
Leu Glu Asp Leu Tyr Lys Arg Phe Lys Ile Pro Gly Ser Pro Pro Glu
    50                  55                  60                  
Ser Met Gly Arg Gly Arg Asp Trp Asn Val Asp Leu Ile Pro Lys Phe
65                  70                  75                  80  
Leu Met Ala Asn Gly Gln Leu Val Lys Met Leu Leu Tyr Thr Glu Val
                85                  90                  95      
Thr Arg Tyr Leu Asp Phe Lys Val Thr Glu Gly Ser Phe Val Tyr Lys
            100                 105                 110         
Gly Gly Lys Ile Tyr Lys Val Pro Ser Thr Glu Ala Glu Ala Leu Ala
        115                 120                 125             
Ser Ser Leu Met Gly Leu Phe Glu Lys Arg Arg Phe Arg Lys Phe Leu
    130                 135                 140                 
Val Tyr Val Ala Asn Phe Asp Glu Lys Asp Pro Arg Thr Phe Glu Gly
145                 150                 155                 160 
Ile Asp Pro Lys Lys Thr Thr Met Arg Asp Val Tyr Lys Lys Phe Asp
                165                 170                 175     
Leu Gly Gln Asp Val Ile Asp Phe Thr Gly His Ala Leu Ala Leu Tyr
            180                 185                 190         
Arg Thr Asp Asp Tyr Leu Asp Gln Pro Cys Tyr Glu Thr Ile Asn Arg
        195                 200                 205             
Ile Lys Leu Tyr Ser Glu Ser Leu Ala Arg Tyr Gly Lys Ser Pro Tyr
    210                 215                 220                 
Leu Tyr Pro Leu Tyr Gly Leu Gly Glu Leu Pro Gln Gly Phe Ala Arg
225                 230                 235                 240 
Leu Ser Ala Ile Tyr Gly Gly Thr Tyr Met Leu Asn Lys Pro Ile Glu
                245                 250                 255     
Glu Ile Ile Val Gln Asn Gly Lys Val Ile Gly Val Lys Ser Glu Gly
            260                 265                 270         
Glu Ile Ala Arg Cys Lys Gln Leu Ile Cys Asp Pro Ser Tyr Val Lys
        275                 280                 285             
Asp Arg Val Glu Lys Val Gly Gln Val Ile Arg Val Ile Cys Ile Leu
    290                 295                 300                 
Ser His Pro Ile Lys Asn Thr Asn Asp Ala Asn Ser Cys Gln Ile Ile
305                 310                 315                 320 
Ile Pro Gln Asn Gln Val Asn Arg Lys Ser Asp Ile Tyr Val Cys Met
                325                 330                 335     
Ile Ser Phe Ala His Asn Val Ala Ala Gln Gly Lys Tyr Ile Ala Ile
            340                 345                 350         
Val Ser Thr Thr Val Glu Thr Lys Glu Pro Glu Lys Glu Ile Arg Pro
        355                 360                 365             
Ala Leu Glu Leu Leu Glu Pro Ile Glu Gln Lys Phe Val Ser Ile Ser
    370                 375                 380                 
Asp Leu Leu Val Pro Lys Asp Leu Gly Thr Glu Ser Gln Ile Phe Ile
385                 390                 395                 400 
Ser Arg Thr Tyr Asp Ala Thr Thr His Phe Glu Thr Thr Cys Asp Asp
                405                 410                 415     
Ile Lys Asn Ile Tyr Lys Arg Met Thr Gly Ser Glu Phe Asp Phe Glu
            420                 425                 430         
Glu Met Lys Arg Lys Lys Asn Asp Ile Tyr Gly Glu Asp
        435                 440                 445 


<210> 755
<211> 305
<212> PRT
<213> Homo sapiens

<400> 755
Cys Ser Arg Ser Val Ala Ser Lys Thr Pro Val Gly Phe Ile Gly Leu
 1               5                  10                  15      
Gly Asn Met Gly Asn Pro Met Ala Lys Asn Leu Met Lys His Gly Tyr
            20                  25                  30          
Pro Leu Ile Ile Tyr Asp Val Phe Pro Asp Ala Cys Lys Glu Phe Gln
        35                  40                  45              
Asp Ala Gly Glu Gln Val Val Ser Ser Pro Ala Asp Val Ala Glu Lys
    50                  55                  60                  
Ala Asp Arg Ile Ile Thr Met Leu Pro Thr Ser Ile Asn Ala Ile Glu
65                  70                  75                  80  
Ala Tyr Ser Gly Ala Asn Gly Ile Leu Lys Lys Val Lys Lys Gly Ser
                85                  90                  95      
Leu Leu Ile Asp Ser Ser Thr Ile Asp Pro Ala Val Ser Lys Glu Leu
            100                 105                 110         
Ala Lys Glu Val Glu Lys Met Gly Ala Val Phe Met Asp Ala Pro Val
        115                 120                 125             
Ser Gly Gly Val Gly Ala Ala Arg Ser Gly Asn Leu Thr Phe Met Val
    130                 135                 140                 
Gly Gly Val Glu Asp Glu Phe Ala Ala Ala Gln Glu Leu Leu Gly Cys
145                 150                 155                 160 
Met Gly Ser Asn Val Val Tyr Cys Gly Ala Val Gly Thr Gly Gln Ala
                165                 170                 175     
Ala Lys Ile Cys Asn Asn Met Leu Leu Ala Ile Ser Met Ile Gly Thr
            180                 185                 190         
Ala Glu Ala Met Asn Leu Gly Ile Arg Leu Gly Leu Asp Pro Lys Leu
        195                 200                 205             
Leu Ala Lys Ile Leu Asn Met Ser Ser Gly Arg Cys Trp Ser Ser Asp
    210                 215                 220                 
Thr Tyr Asn Pro Val Pro Gly Val Met Asp Gly Val Pro Ser Ala Asn
225                 230                 235                 240 
Asn Tyr Gln Gly Gly Phe Gly Thr Thr Leu Met Ala Lys Asp Leu Gly
                245                 250                 255     
Leu Ala Gln Asp Ser Ala Thr Ser Thr Lys Ser Pro Ile Leu Leu Gly
            260                 265                 270         
Ser Leu Ala His Gln Ile Tyr Arg Met Met Cys Ala Lys Gly Tyr Ser
        275                 280                 285             
Lys Lys Asp Phe Ser Ser Val Phe Gln Phe Leu Arg Glu Glu Glu Thr
    290                 295                 300                 
Phe
305 


<210> 756
<211> 1462
<212> PRT
<213> Homo sapiens

<400> 756
Met Gly Ala Gln Asp Arg Pro Gln Cys His Phe Asp Ile Glu Ile Asn
 1               5                  10                  15      
Arg Glu Pro Val Gly Arg Ile Met Phe Gln Leu Phe Ser Asp Ile Cys
            20                  25                  30          
Pro Lys Thr Cys Lys Asn Phe Leu Cys Leu Cys Ser Gly Glu Lys Gly
        35                  40                  45              
Leu Gly Lys Thr Thr Gly Lys Lys Leu Cys Tyr Lys Gly Ser Thr Phe
    50                  55                  60                  
His Arg Val Val Lys Asn Phe Met Ile Gln Gly Gly Asp Phe Ser Glu
65                  70                  75                  80  
Gly Asn Gly Lys Gly Gly Glu Ser Ile Tyr Gly Gly Tyr Phe Lys Asp
                85                  90                  95      
Glu Asn Phe Ile Leu Lys His Asp Arg Ala Phe Leu Leu Ser Met Ala
            100                 105                 110         
Asn Arg Gly Lys His Thr Asn Gly Ser Gln Phe Phe Ile Thr Thr Lys
        115                 120                 125             
Pro Ala Pro His Leu Asp Gly Val His Val Val Phe Gly Leu Val Ile
    130                 135                 140                 
Ser Gly Phe Glu Val Ile Glu Gln Ile Glu Asn Leu Lys Thr Asp Ala
145                 150                 155                 160 
Ala Ser Arg Pro Tyr Ala Asp Val Arg Val Ile Asp Cys Gly Val Leu
                165                 170                 175     
Ala Thr Lys Ser Ile Lys Asp Val Phe Glu Lys Lys Arg Lys Lys Pro
            180                 185                 190         
Thr His Ser Glu Gly Ser Asp Ser Ser Ser Asn Ser Ser Ser Ser Ser
        195                 200                 205             
Glu Ser Ser Ser Glu Ser Glu Leu Glu His Glu Arg Ser Arg Arg Arg
    210                 215                 220                 
Lys His Lys Arg Arg Pro Lys Val Lys Arg Ser Lys Lys Arg Arg Lys
225                 230                 235                 240 
Glu Ala Ser Ser Ser Glu Glu Pro Arg Asn Lys His Ala Met Asn Pro
                245                 250                 255     
Lys Gly His Ser Glu Arg Ser Asp Thr Asn Glu Lys Arg Ser Val Asp
            260                 265                 270         
Ser Ser Ala Lys Arg Glu Lys Pro Val Val Arg Pro Glu Glu Ile Pro
        275                 280                 285             
Pro Val Pro Glu Asn Arg Phe Leu Leu Arg Arg Asp Met Pro Val Val
    290                 295                 300                 
Thr Ala Glu Pro Glu Pro Lys Ile Pro Asp Val Ala Pro Ile Val Ser
305                 310                 315                 320 
Asp Gln Lys Pro Ser Val Ser Lys Ser Gly Arg Lys Ile Lys Gly Arg
                325                 330                 335     
Gly Thr Ile Arg Tyr His Thr Pro Pro Arg Ser Arg Ser Cys Ser Glu
            340                 345                 350         
Ser Asp Asp Asp Asp Ser Ser Glu Thr Pro Pro His Trp Lys Glu Glu
        355                 360                 365             
Met Gln Arg Leu Arg Ala Tyr Arg Pro Pro Ser Gly Glu Lys Trp Ser
    370                 375                 380                 
Lys Gly Asp Lys Leu Ser Asp Pro Cys Ser Ser Arg Trp Asp Glu Arg
385                 390                 395                 400 
Ser Leu Ser Gln Arg Ser Arg Ser Trp Ser Tyr Asn Gly Tyr Tyr Ser
                405                 410                 415     
Asp Leu Ser Thr Ala Arg His Ser Gly His His Lys Lys Arg Arg Lys
            420                 425                 430         
Glu Lys Lys Val Lys His Lys Lys Lys Gly Lys Lys Gln Lys His Cys
        435                 440                 445             
Arg Arg His Lys Gln Thr Lys Lys Arg Arg Ile Leu Ile Pro Ser Asp
    450                 455                 460                 
Ile Glu Ser Ser Lys Ser Ser Thr Arg Arg Met Lys Ser Ser Cys Asp
465                 470                 475                 480 
Arg Glu Arg Ser Ser Arg Ser Ser Ser Leu Ser Ser His His Ser Ser
                485                 490                 495     
Lys Arg Asp Trp Ser Lys Ser Asp Lys Asp Val Gln Ser Ser Leu Thr
            500                 505                 510         
His Ser Ser Arg Asp Ser Tyr Arg Ser Lys Ser His Ser Gln Ser Tyr
        515                 520                 525             
Ser Arg Gly Ser Ser Arg Ser Arg Thr Ala Ser Lys Ser Ser Ser His
    530                 535                 540                 
Ser Arg Ser Arg Ser Lys Ser Arg Ser Ser Ser Lys Ser Gly His Arg
545                 550                 555                 560 
Lys Arg Ala Ser Lys Ser Pro Arg Lys Thr Ala Ser Gln Leu Ser Glu
                565                 570                 575     
Asn Lys Pro Val Lys Thr Glu Pro Leu Arg Ala Thr Met Ala Gln Asn
            580                 585                 590         
Glu Asn Val Val Val Gln Pro Val Val Ala Glu Asn Ile Pro Val Ile
        595                 600                 605             
Pro Leu Ser Asp Ser Pro Pro Pro Ser Arg Trp Lys Pro Gly Gln Lys
    610                 615                 620                 
Pro Trp Lys Pro Ser Tyr Glu Arg Ile Gln Glu Met Lys Ala Lys Thr
625                 630                 635                 640 
Thr His Leu Leu Pro Ile Gln Ser Thr Tyr Ser Leu Ala Asn Ile Lys
                645                 650                 655     
Glu Thr Gly Ser Ser Ser Ser Tyr His Lys Arg Glu Lys Asn Ser Glu
            660                 665                 670         
Ser Asp Gln Ser Thr Tyr Ser Lys Tyr Ser Asp Arg Ser Ser Glu Ser
        675                 680                 685             
Ser Pro Arg Ser Arg Ser Arg Ser Ser Arg Ser Arg Ser Tyr Ser Arg
    690                 695                 700                 
Ser Tyr Thr Arg Ser Arg Ser Leu Ala Ser Ser His Ser Arg Ser Arg
705                 710                 715                 720 
Ser Pro Ser Ser Arg Ser His Ser Arg Asn Lys Tyr Ser Asp His Ser
                725                 730                 735     
Gln Cys Ser Arg Ser Ser Ser Tyr Thr Ser Ile Ser Ser Asp Asp Gly
            740                 745                 750         
Arg Arg Ala Lys Arg Arg Leu Arg Ser Ser Gly Lys Lys Asn Ser Val
        755                 760                 765             
Ser His Lys Lys His Ser Ser Ser Ser Glu Lys Thr Leu His Ser Lys
    770                 775                 780                 
Tyr Val Lys Gly Arg Asp Arg Ser Ser Cys Val Arg Lys Tyr Ser Glu
785                 790                 795                 800 
Ser Arg Ser Ser Leu Asp Tyr Ser Ser Asp Ser Glu Gln Ser Ser Val
                805                 810                 815     
Gln Ala Thr Gln Ser Ala Gln Glu Lys Glu Lys Gln Gly Gln Met Glu
            820                 825                 830         
Arg Thr His Asn Lys Gln Glu Lys Asn Arg Gly Glu Glu Lys Ser Lys
        835                 840                 845             
Ser Glu Arg Glu Cys Pro His Ser Lys Lys Arg Thr Leu Lys Glu Asn
    850                 855                 860                 
Leu Ser Asp His Leu Arg Asn Gly Ser Lys Pro Lys Arg Lys Asn Tyr
865                 870                 875                 880 
Ala Gly Ser Lys Trp Asp Ser Glu Ser Asn Ser Glu Arg Asp Val Thr
                885                 890                 895     
Lys Asn Ser Lys Asn Asp Ser His Pro Ser Ser Asp Lys Glu Glu Gly
            900                 905                 910         
Glu Ala Thr Ser Asp Ser Glu Ser Glu Val Ser Glu Ile His Ile Lys
        915                 920                 925             
Val Lys Pro Thr Thr Lys Ser Ser Thr Asn Thr Ser Leu Pro Asp Asp
    930                 935                 940                 
Asn Gly Ala Trp Lys Ser Ser Lys Gln Arg Thr Ser Thr Ser Asp Ser
945                 950                 955                 960 
Glu Gly Ser Cys Ser Asn Ser Glu Asn Asn Arg Gly Lys Pro Gln Lys
                965                 970                 975     
His Lys His Gly Ser Lys Glu Asn Leu Lys Arg Glu His Thr Lys Lys
            980                 985                 990         
Val Lys Glu Lys Leu Lys Gly Lys Lys Asp Lys Lys His Lys Ala Pro
        995                 1000                1005            
Lys Arg Lys Gln Ala Phe His Trp Gln Pro Pro Leu Glu Phe Gly Glu
    1010                1015                1020                
Glu Glu Glu Glu Glu Ile Asp Asp Lys Gln Val Thr Gln Glu Ser Lys
1025                1030                1035                1040
Glu Lys Lys Val Ser Glu Asn Asn Glu Thr Ile Lys Asp Asn Ile Leu
                1045                1050                1055    
Lys Thr Glu Lys Ser Ser Glu Glu Asp Leu Ser Gly Lys His Asp Thr
            1060                1065                1070        
Val Thr Val Ser Ser Asp Leu Asp Gln Phe Thr Lys Asp Asp Ser Lys
        1075                1080                1085            
Leu Ser Ile Ser Pro Thr Ala Leu Asn Thr Glu Glu Asn Val Ala Cys
    1090                1095                1100                
Leu Gln Asn Ile Gln His Val Glu Glu Ser Val Pro Asn Gly Val Glu
1105                1110                1115                1120
Asp Val Leu Gln Thr Asp Asp Asn Met Glu Ile Cys Thr Pro Asp Arg
                1125                1130                1135    
Ser Ser Pro Ala Lys Val Glu Glu Thr Ser Pro Leu Gly Asn Ala Arg
            1140                1145                1150        
Leu Asp Thr Pro Asp Ile Asn Ile Val Leu Lys Gln Asp Met Ala Thr
        1155                1160                1165            
Glu His Pro Gln Ala Glu Val Val Lys Gln Glu Ser Ser Met Ser Glu
    1170                1175                1180                
Ser Lys Val Leu Gly Glu Val Gly Lys Gln Asp Ser Ser Ser Ala Ser
1185                1190                1195                1200
Leu Ala Ser Ala Gly Glu Ser Thr Gly Lys Lys Glu Val Ala Glu Lys
                1205                1210                1215    
Ser Gln Ile Asn Leu Ile Asp Lys Lys Trp Lys Pro Leu Gln Gly Val
            1220                1225                1230        
Gly Asn Leu Ala Ala Pro Asn Ala Ala Thr Ser Ser Ala Val Glu Val
        1235                1240                1245            
Lys Val Leu Thr Thr Val Pro Glu Met Lys Pro Gln Gly Leu Arg Ile
    1250                1255                1260                
Glu Ile Lys Ser Lys Asn Lys Val Arg Pro Gly Ser Leu Phe Asp Glu
1265                1270                1275                1280
Val Arg Lys Thr Ala Arg Leu Asn Arg Arg Pro Arg Asn Gln Glu Ser
                1285                1290                1295    
Ser Ser Asp Glu Gln Thr Pro Ser Arg Asp Asp Asp Ser Gln Ser Arg
            1300                1305                1310        
Ser Pro Ser Arg Ser Arg Ser Lys Ser Glu Thr Lys Ser Arg His Arg
        1315                1320                1325            
Thr Arg Ser Val Ser Tyr Ser His Ser Arg Ser Arg Ser Arg Ser Ser
    1330                1335                1340                
Thr Ser Ser Tyr Arg Ser Arg Ser Tyr Ser Arg Ser Arg Ser Arg Gly
1345                1350                1355                1360
Trp Tyr Ser Arg Gly Arg Thr Arg Ser Arg Ser Ser Ser Tyr Arg Ser
                1365                1370                1375    
Tyr Lys Ser His Arg Thr Ser Ser Arg Ser Arg Ser Arg Ser Ser Ser
            1380                1385                1390        
Tyr Asp Pro His Ser Arg Ser Arg Ser Tyr Thr Tyr Asp Ser Tyr Tyr
        1395                1400                1405            
Ser Arg Ser Arg Ser Arg Ser Arg Ser Gln Arg Ser Asp Ser Tyr His
    1410                1415                1420                
Arg Gly Arg Ser Tyr Asn Arg Arg Ser Arg Ser Cys Arg Ser Tyr Gly
1425                1430                1435                1440
Ser Asp Ser Glu Ser Asp Arg Ser Tyr Ser His His Arg Ser Pro Ser
                1445                1450                1455    
Glu Ser Ser Arg Tyr Ser
            1460        


<210> 757
<211> 379
<212> PRT
<213> Homo sapiens

<400> 757
Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Val Gly
 1               5                  10                  15      
Gly Glu Arg Ser Ser Arg Pro Ala Pro Ser Val Ala Pro Glu Pro Asp
            20                  25                  30          
Gly Cys Pro Val Cys Val Trp Arg Gln His Ser Arg Glu Leu Arg Leu
        35                  40                  45              
Glu Ser Ile Lys Ser Gln Ile Leu Ser Lys Leu Arg Leu Lys Glu Ala
    50                  55                  60                  
Pro Asn Ile Ser Arg Glu Val Val Lys Gln Leu Leu Pro Lys Ala Pro
65                  70                  75                  80  
Pro Leu Gln Gln Ile Leu Asp Leu His Asp Phe Gln Gly Asp Ala Leu
                85                  90                  95      
Gln Pro Glu Asp Phe Leu Glu Glu Asp Glu Tyr His Ala Thr Thr Glu
            100                 105                 110         
Thr Val Ile Ser Met Ala Gln Glu Thr Asp Pro Ala Val Gln Thr Asp
        115                 120                 125             
Gly Ser Pro Leu Cys Cys His Phe His Phe Ser Pro Lys Val Met Phe
    130                 135                 140                 
Thr Lys Val Leu Lys Ala Gln Leu Trp Val Tyr Leu Arg Pro Val Pro
145                 150                 155                 160 
Arg Pro Ala Thr Val Tyr Leu Gln Ile Leu Arg Leu Lys Pro Leu Thr
                165                 170                 175     
Gly Glu Gly Thr Ala Gly Gly Gly Gly Gly Gly Arg Arg His Ile Arg
            180                 185                 190         
Ile Arg Ser Leu Lys Ile Glu Leu His Ser Arg Ser Gly His Trp Gln
        195                 200                 205             
Ser Ile Asp Phe Lys Gln Val Leu His Ser Trp Phe Arg Gln Pro Gln
    210                 215                 220                 
Ser Asn Trp Gly Ile Glu Ile Asn Ala Phe Asp Pro Ser Gly Thr Asp
225                 230                 235                 240 
Leu Ala Val Thr Ser Leu Gly Pro Gly Ala Glu Gly Leu His Pro Phe
                245                 250                 255     
Met Glu Leu Arg Val Leu Glu Asn Thr Lys Arg Ser Arg Arg Asn Leu
            260                 265                 270         
Gly Leu Asp Cys Asp Glu His Ser Ser Glu Ser Arg Cys Cys Arg Tyr
        275                 280                 285             
Pro Leu Thr Val Asp Phe Glu Ala Phe Gly Trp Asp Trp Ile Ile Ala
    290                 295                 300                 
Pro Lys Arg Tyr Lys Ala Asn Tyr Cys Ser Gly Gln Cys Glu Tyr Met
305                 310                 315                 320 
Phe Met Gln Lys Tyr Pro His Thr His Leu Val Gln Gln Ala Asn Pro
                325                 330                 335     
Arg Gly Ser Ala Gly Pro Cys Cys Thr Pro Thr Lys Met Ser Pro Ile
            340                 345                 350         
Asn Met Leu Tyr Phe Asn Asp Lys Gln Gln Ile Ile Tyr Gly Lys Ile
        355                 360                 365             
Pro Gly Met Val Val Asp Arg Cys Gly Cys Ser
    370                 375                 


<210> 758
<211> 886
<212> PRT
<213> Homo sapiens

<400> 758
Met Glu Gly Glu Ser Ser Arg Phe Glu Ile His Thr Pro Val Ser Asp
 1               5                  10                  15      
Lys Lys Lys Lys Lys Cys Ser Ile His Lys Glu Arg Pro Gln Lys His
            20                  25                  30          
Ser His Glu Ile Phe Arg Asp Ser Ser Leu Val Asn Glu Gln Ser Gln
        35                  40                  45              
Ile Thr Arg Arg Lys Lys Arg Lys Lys Asp Phe Gln His Leu Ile Ser
    50                  55                  60                  
Ser Pro Leu Lys Lys Ser Arg Ile Cys Asp Glu Thr Ala Asn Ala Thr
65                  70                  75                  80  
Ser Thr Leu Lys Lys Arg Lys Lys Arg Arg Tyr Ser Ala Leu Glu Val
                85                  90                  95      
Asp Glu Glu Ala Gly Val Thr Val Val Leu Val Asp Lys Glu Asn Ile
            100                 105                 110         
Asn Asn Thr Pro Lys His Phe Arg Lys Asp Val Asp Val Val Cys Val
        115                 120                 125             
Asp Met Ser Ile Glu Gln Lys Leu Pro Arg Lys Pro Lys Thr Asp Lys
    130                 135                 140                 
Phe Gln Val Leu Ala Lys Ser His Ala His Lys Ser Glu Ala Leu His
145                 150                 155                 160 
Ser Lys Val Arg Glu Lys Lys Asn Lys Lys His Gln Arg Lys Ala Ala
                165                 170                 175     
Ser Trp Glu Ser Gln Arg Ala Arg Asp Thr Leu Pro Gln Ser Glu Ser
            180                 185                 190         
His Gln Glu Glu Ser Trp Leu Ser Val Gly Pro Gly Gly Glu Ile Thr
        195                 200                 205             
Glu Leu Pro Ala Ser Ala His Lys Asn Lys Ser Lys Lys Lys Lys Lys
    210                 215                 220                 
Lys Ser Ser Asn Arg Glu Tyr Glu Thr Leu Ala Met Pro Glu Gly Ser
225                 230                 235                 240 
Gln Ala Gly Arg Glu Ala Gly Thr Asp Met Gln Glu Ser Gln Pro Thr
                245                 250                 255     
Val Gly Leu Asp Asp Glu Thr Pro Gln Leu Leu Gly Pro Thr His Lys
            260                 265                 270         
Lys Lys Ser Lys Lys Lys Lys Lys Lys Lys Ser Asn His Gln Glu Phe
        275                 280                 285             
Glu Ala Leu Ala Met Pro Glu Gly Ser Gln Val Gly Ser Glu Val Gly
    290                 295                 300                 
Ala Asp Met Gln Glu Ser Arg Pro Ala Val Gly Leu His Gly Glu Thr
305                 310                 315                 320 
Ala Gly Ile Pro Ala Pro Ala Tyr Lys Asn Lys Ser Lys Lys Lys Lys
                325                 330                 335     
Lys Lys Ser Asn His Gln Glu Phe Glu Ala Val Ala Met Pro Glu Ser
            340                 345                 350         
Leu Glu Ser Ala Tyr Pro Glu Gly Ser Gln Val Gly Ser Glu Val Gly
        355                 360                 365             
Thr Val Glu Gly Ser Thr Ala Leu Lys Gly Phe Lys Glu Ser Asn Ser
    370                 375                 380                 
Thr Lys Lys Lys Ser Lys Lys Arg Lys Leu Thr Ser Val Lys Arg Ala
385                 390                 395                 400 
Arg Val Ser Gly Asp Asp Phe Ser Val Pro Ser Lys Asn Ser Glu Ser
                405                 410                 415     
Thr Leu Phe Asp Ser Val Glu Gly Asp Gly Ala Met Met Glu Glu Gly
            420                 425                 430         
Val Lys Ser Arg Pro Arg Gln Lys Lys Thr Gln Ala Cys Leu Ala Ser
        435                 440                 445             
Lys His Val Gln Glu Ala Pro Arg Leu Glu Pro Ala Asn Glu Glu His
    450                 455                 460                 
Asn Val Glu Thr Ala Glu Asp Ser Glu Ile Arg Tyr Leu Ser Ala Asp
465                 470                 475                 480 
Ser Gly Asp Ala Asp Asp Ser Asp Ala Asp Leu Gly Ser Ala Val Lys
                485                 490                 495     
Gln Leu Gln Glu Phe Ile Pro Asn Ile Lys Asp Arg Ala Thr Ser Thr
            500                 505                 510         
Ile Lys Arg Met Tyr Arg Asp Asp Leu Glu Arg Phe Lys Glu Phe Lys
        515                 520                 525             
Ala Gln Gly Val Ala Ile Lys Phe Gly Lys Phe Ser Val Lys Glu Asn
    530                 535                 540                 
Lys Gln Leu Glu Lys Asn Val Glu Asp Phe Leu Ala Leu Thr Gly Ile
545                 550                 555                 560 
Glu Ser Ala Asp Lys Leu Leu Tyr Thr Asp Arg Tyr Pro Glu Glu Lys
                565                 570                 575     
Ser Val Ile Thr Asn Leu Lys Arg Arg Tyr Ser Phe Arg Leu His Ile
            580                 585                 590         
Gly Arg Asn Ile Ala Arg Pro Trp Lys Leu Ile Tyr Tyr Arg Ala Lys
        595                 600                 605             
Lys Met Phe Asp Val Asn Asn Tyr Lys Gly Arg Tyr Ser Glu Gly Asp
    610                 615                 620                 
Thr Glu Lys Leu Lys Met Tyr His Ser Leu Leu Gly Asn Asp Trp Lys
625                 630                 635                 640 
Thr Ile Gly Glu Met Val Ala Arg Arg Ser Leu Ser Val Ala Leu Lys
                645                 650                 655     
Phe Ser Gln Ile Ser Ser Gln Arg Asn Arg Gly Ala Trp Ser Lys Ser
            660                 665                 670         
Glu Thr Arg Lys Leu Ile Lys Ala Val Glu Glu Val Ile Leu Lys Lys
        675                 680                 685             
Met Ser Pro Gln Glu Leu Lys Glu Val Asp Ser Lys Leu Gln Glu Asn
    690                 695                 700                 
Pro Glu Ser Cys Leu Ser Ile Val Arg Glu Lys Leu Tyr Lys Gly Ile
705                 710                 715                 720 
Ser Trp Val Glu Val Glu Ala Lys Val Gln Thr Arg Asn Trp Met Gln
                725                 730                 735     
Cys Lys Ser Lys Trp Thr Glu Ile Leu Thr Lys Arg Met Thr Asn Gly
            740                 745                 750         
Arg Arg Ile Tyr Tyr Gly Met Asn Ala Leu Arg Ala Lys Val Ser Leu
        755                 760                 765             
Ile Glu Arg Leu Tyr Glu Ile Asn Val Glu Asp Thr Asn Glu Ile Asp
    770                 775                 780                 
Trp Glu Asp Leu Ala Ser Ala Ile Gly Asp Val Pro Pro Ser Tyr Val
785                 790                 795                 800 
Gln Thr Lys Phe Ser Arg Leu Lys Ala Val Tyr Val Pro Phe Trp Gln
                805                 810                 815     
Lys Lys Thr Phe Pro Glu Ile Ile Asp Tyr Leu Tyr Glu Thr Thr Leu
            820                 825                 830         
Pro Leu Leu Lys Glu Lys Leu Glu Lys Met Met Glu Lys Lys Gly Thr
        835                 840                 845             
Lys Ile Gln Thr Pro Ala Ala Pro Lys Gln Val Phe Pro Phe Arg Asp
    850                 855                 860                 
Ile Phe Tyr Tyr Glu Asp Asp Ser Glu Gly Gly Gly His Arg Lys Arg
865                 870                 875                 880 
Lys Arg Arg Gly Ile Pro
                885     


<210> 759
<211> 377
<212> PRT
<213> Homo sapiens

<400> 759
Met Ala Ala Ala Ala Gln Ser Arg Val Val Arg Val Leu Ser Met Ser
 1               5                  10                  15      
Arg Ser Ala Ile Thr Ala Ile Ala Thr Ser Val Cys His Gly Pro Pro
            20                  25                  30          
Cys Arg Gln Leu His His Ala Leu Met Pro His Gly Lys Gly Gly Arg
        35                  40                  45              
Ser Ser Val Ser Gly Ile Val Ala Thr Val Phe Gly Ala Thr Gly Phe
    50                  55                  60                  
Leu Gly Arg Tyr Val Val Asn His Leu Gly Arg Met Gly Ser Gln Val
65                  70                  75                  80  
Ile Ile Pro Tyr Arg Cys Asp Lys Tyr Asp Ile Met His Leu Arg Pro
                85                  90                  95      
Met Gly Asp Leu Gly Gln Leu Leu Phe Leu Glu Trp Asp Ala Arg Asp
            100                 105                 110         
Lys Asp Ser Ile Arg Arg Val Val Gln His Ser Asn Val Val Ile Asn
        115                 120                 125             
Leu Ile Gly Arg Asp Trp Glu Thr Lys Asn Phe Asp Phe Glu Asp Val
    130                 135                 140                 
Phe Val Lys Ile Pro Gln Ala Ile Ala Gln Leu Ser Lys Glu Ala Gly
145                 150                 155                 160 
Val Glu Lys Phe Ile His Val Ser His Leu Asn Ala Asn Ile Lys Ser
                165                 170                 175     
Ser Ser Arg Tyr Leu Arg Asn Lys Ala Val Gly Glu Lys Val Val Arg
            180                 185                 190         
Asp Ala Phe Pro Glu Ala Ile Ile Val Lys Pro Ser Asp Ile Phe Gly
        195                 200                 205             
Arg Glu Asp Arg Phe Leu Asn Ser Phe Ala Ser Met His Arg Phe Gly
    210                 215                 220                 
Pro Ile Pro Leu Gly Ser Leu Gly Trp Lys Thr Val Lys Gln Pro Val
225                 230                 235                 240 
Tyr Val Val Asp Val Ser Lys Gly Ile Val Asn Ala Val Lys Asp Pro
                245                 250                 255     
Asp Ala Asn Gly Lys Ser Phe Ala Phe Val Gly Pro Ser Arg Tyr Leu
            260                 265                 270         
Leu Phe His Leu Val Lys Tyr Ile Phe Ala Val Ala His Arg Leu Phe
        275                 280                 285             
Leu Pro Phe Pro Leu Pro Leu Phe Ala Tyr Arg Trp Val Ala Arg Val
    290                 295                 300                 
Phe Glu Ile Ser Pro Phe Glu Pro Trp Ile Thr Arg Asp Lys Val Glu
305                 310                 315                 320 
Arg Met His Ile Thr Asp Met Lys Leu Pro His Leu Pro Gly Leu Glu
                325                 330                 335     
Asp Leu Gly Ile Gln Ala Thr Pro Leu Glu Leu Lys Ala Ile Glu Val
            340                 345                 350         
Leu Arg Arg His Arg Thr Tyr Arg Trp Leu Ser Ala Glu Ile Glu Asp
        355                 360                 365             
Val Lys Pro Ala Lys Thr Val Asn Ile
    370                 375         


<210> 760
<211> 1310
<212> PRT
<213> Homo sapiens

<400> 760
Thr Phe His Arg Thr Lys Ser Ser Gly Trp Pro Pro Pro Ser Gly Thr
 1               5                  10                  15      
Trp Gly Leu Ser Gln Val Pro Pro Tyr Gly Trp Glu Met Thr Ala Asn
            20                  25                  30          
Arg Asp Gly Arg Asp Tyr Phe Ile Asn His Met Thr Gln Ala Ile Pro
        35                  40                  45              
Phe Asp Asp Pro Arg Leu Glu Ser Cys Gln Ile Ile Pro Pro Ala Pro
    50                  55                  60                  
Arg Lys Val Glu Met Arg Arg Asp Pro Val Leu Gly Phe Gly Phe Val
65                  70                  75                  80  
Ala Gly Ser Glu Lys Pro Val Val Val Arg Ser Val Thr Pro Gly Gly
                85                  90                  95      
Pro Ser Glu Gly Lys Leu Ile Pro Gly Asp Gln Ile Val Met Ile Asn
            100                 105                 110         
Asp Glu Pro Val Ser Ala Ala Pro Arg Glu Arg Val Ile Asp Leu Val
        115                 120                 125             
Arg Ser Cys Lys Glu Ser Ile Leu Leu Thr Val Ile Gln Pro Tyr Pro
    130                 135                 140                 
Ser Pro Lys Ser Ala Phe Ile Ser Ala Ala Lys Lys Ala Arg Leu Lys
145                 150                 155                 160 
Ser Asn Pro Val Lys Val Arg Phe Ser Glu Glu Val Ile Ile Asn Gly
                165                 170                 175     
Gln Val Ser Glu Thr Val Lys Asp Asn Ser Leu Leu Phe Met Pro Asn
            180                 185                 190         
Val Leu Lys Val Tyr Leu Glu Asn Gly Gln Thr Lys Ser Phe Arg Phe
        195                 200                 205             
Asp Cys Ser Thr Ser Ile Lys Asp Val Ile Leu Thr Leu Gln Glu Lys
    210                 215                 220                 
Leu Ser Ile Lys Gly Ile Glu His Phe Ser Leu Met Leu Glu Gln Arg
225                 230                 235                 240 
Thr Glu Gly Ala Gly Thr Lys Leu Leu Leu Leu His Glu Gln Glu Thr
                245                 250                 255     
Leu Thr Gln Val Thr Gln Arg Pro Ser Ser His Lys Met Arg Cys Leu
            260                 265                 270         
Phe Arg Ile Ser Phe Val Pro Lys Asp Pro Ile Asp Leu Leu Arg Arg
        275                 280                 285             
Asp Pro Val Ala Phe Glu Tyr Leu Tyr Val Gln Ser Cys Asn Asp Val
    290                 295                 300                 
Val Gln Glu Arg Phe Gly Pro Glu Leu Lys Tyr Asp Ile Ala Leu Arg
305                 310                 315                 320 
Leu Ala Ala Leu Gln Met Tyr Ile Ala Thr Val Thr Thr Lys Gln Thr
                325                 330                 335     
Gln Lys Ile Ser Leu Lys Tyr Ile Glu Lys Glu Trp Gly Leu Glu Thr
            340                 345                 350         
Phe Leu Pro Ser Ala Val Leu Gln Ser Met Lys Glu Lys Asn Ile Lys
        355                 360                 365             
Lys Ala Leu Ser His Leu Val Lys Ala Asn Gln Asn Leu Val Pro Pro
    370                 375                 380                 
Gly Lys Lys Leu Ser Ala Leu Gln Ala Lys Val His Tyr Leu Lys Phe
385                 390                 395                 400 
Leu Ser Asp Leu Arg Leu Tyr Gly Gly Arg Val Phe Lys Ala Thr Leu
                405                 410                 415     
Val Gln Ala Glu Lys Arg Ser Glu Val Thr Leu Leu Val Gly Pro Arg
            420                 425                 430         
Tyr Gly Ile Ser His Val Ile Asn Thr Lys Thr Asn Leu Val Ala Leu
        435                 440                 445             
Leu Ala Asp Phe Ser His Val Asn Arg Ile Glu Met Phe Ser Glu Glu
    450                 455                 460                 
Glu Ser Leu Val Arg Val Glu Leu His Val Leu Asp Val Lys Pro Ile
465                 470                 475                 480 
Thr Leu Leu Met Glu Ser Ser Asp Ala Met Asn Leu Ala Cys Leu Thr
                485                 490                 495     
Ala Gly Tyr Tyr Arg Leu Leu Val Asp Ser Arg Arg Ser Ile Phe Asn
            500                 505                 510         
Met Ala Asn Lys Lys Asn Thr Ala Thr Gln Glu Thr Gly Pro Glu Asn
        515                 520                 525             
Lys Gly Lys His Asn Leu Leu Gly Pro Asp Trp Asn Cys Ile Pro Gln
    530                 535                 540                 
Met Thr Thr Phe Ile Gly Glu Gly Glu Gln Glu Ala Gln Ile Thr Tyr
545                 550                 555                 560 
Ile Asp Ser Lys Gln Lys Thr Val Glu Ile Thr Asp Ser Thr Met Cys
                565                 570                 575     
Pro Lys Glu His Arg His Leu Tyr Ile Asp Asn Ala Tyr Ser Ser Asp
            580                 585                 590         
Gly Leu Asn Gln Gln Leu Ser Gln Pro Gly Glu Ala Pro Cys Glu Ala
        595                 600                 605             
Asp Tyr Arg Ser Leu Ala Gln Arg Ser Leu Leu Thr Leu Ser Gly Pro
    610                 615                 620                 
Glu Thr Leu Lys Lys Ala Gln Glu Ser Pro Arg Gly Ala Lys Val Ser
625                 630                 635                 640 
Phe Ile Phe Gly Asp Phe Ala Leu Asp Asp Gly Ile Ser Pro Pro Thr
                645                 650                 655     
Leu Gly Tyr Glu Thr Leu Leu Asp Glu Gly Pro Glu Met Leu Glu Lys
            660                 665                 670         
Gln Arg Asn Leu Tyr Ile Gly Ser Ala Asn Asp Met Lys Gly Leu Asp
        675                 680                 685             
Leu Thr Pro Glu Ala Glu Gly Ile Gln Phe Val Glu Asn Ser Val Tyr
    690                 695                 700                 
Ala Asn Ile Gly Asp Val Lys Ser Phe Gln Ala Ala Glu Gly Ile Glu
705                 710                 715                 720 
Glu Pro Leu Leu His Asp Ile Cys Tyr Ala Glu Asn Thr Asp Asp Ala
                725                 730                 735     
Glu Asp Glu Asp Glu Val Ser Cys Glu Glu Asp Leu Val Val Gly Glu
            740                 745                 750         
Met Asn Gln Pro Ala Ile Leu Asn Leu Ser Gly Ser Ser Asp Asp Ile
        755                 760                 765             
Ile Asp Leu Thr Ser Leu Pro Pro Pro Glu Gly Asp Asp Asn Glu Asp
    770                 775                 780                 
Asp Phe Leu Leu Arg Ser Leu Asn Met Ala Ile Ala Ala Pro Pro Pro
785                 790                 795                 800 
Gly Phe Arg Asp Ser Ser Asp Glu Glu Asp Ser Gln Ser Gln Ala Ala
                805                 810                 815     
Ser Phe Pro Glu Asp Lys Glu Lys Gly Ser Ser Leu Gln Asn Asp Glu
            820                 825                 830         
Ile Pro Val Ser Leu Ile Asp Ala Val Pro Thr Ser Ala Glu Gly Lys
        835                 840                 845             
Cys Glu Lys Gly Leu Asp Asn Ala Val Val Ser Thr Leu Gly Ala Leu
    850                 855                 860                 
Glu Ala Leu Ser Val Ser Glu Glu Gln Gln Thr Ser Asp Asn Ser Gly
865                 870                 875                 880 
Val Ala Ile Leu Arg Ala Tyr Ser Pro Glu Ser Ser Ser Asp Ser Gly
                885                 890                 895     
Asn Glu Thr Asn Ser Ser Glu Met Thr Glu Ser Ser Glu Leu Ala Thr
            900                 905                 910         
Ala Gln Lys Gln Ser Glu Asn Leu Ser Arg Met Phe Leu Ala Thr His
        915                 920                 925             
Glu Gly Tyr His Pro Leu Ala Glu Glu Gln Thr Glu Phe Pro Ala Ser
    930                 935                 940                 
Lys Thr Pro Ala Gly Gly Leu Pro Pro Lys Ser Ser His Ala Leu Ala
945                 950                 955                 960 
Ala Arg Pro Ala Thr Asp Leu Pro Pro Lys Val Val Pro Ser Lys Gln
                965                 970                 975     
Leu Leu His Ser Asp His Met Glu Met Glu Pro Glu Thr Met Glu Thr
            980                 985                 990         
Lys Ser Val Thr Asp Tyr Phe Ser Lys Leu His Met Gly Ser Val Ala
        995                 1000                1005            
Tyr Ser Cys Thr Ser Lys Arg Lys Ser Lys Leu Ala Asp Gly Glu Gly
    1010                1015                1020                
Lys Ala Pro Pro Asn Gly Asn Thr Thr Gly Lys Lys Gln Gln Gly Thr
1025                1030                1035                1040
Lys Thr Ala Glu Met Glu Glu Glu Ala Ser Gly Lys Phe Gly Thr Val
                1045                1050                1055    
Ser Ser Arg Asp Ser Gln His Leu Ser Thr Phe Asn Leu Glu Arg Thr
            1060                1065                1070        
Ala Phe Arg Lys Asp Ser Gln Arg Trp Tyr Val Ala Thr Glu Gly Gly
        1075                1080                1085            
Met Ala Glu Lys Ser Gly Leu Glu Ala Ala Thr Gly Lys Thr Phe Pro
    1090                1095                1100                
Arg Ala Ser Gly Leu Gly Ala Arg Glu Ala Glu Gly Lys Glu Glu Gly
1105                1110                1115                1120
Ala Pro Asp Gly Glu Thr Ser Asp Gly Ser Gly Leu Gly Gln Gly Asp
                1125                1130                1135    
Arg Phe Leu Thr Asp Val Thr Cys Ala Ser Ser Ala Lys Asp Leu Asp
            1140                1145                1150        
Asn Pro Glu Asp Ala Asp Ser Ser Thr Cys Asp His Pro Ser Lys Leu
        1155                1160                1165            
Pro Glu Ala Asp Glu Ser Val Ala Arg Leu Cys Asp Tyr His Leu Ala
    1170                1175                1180                
Lys Arg Met Ser Ser Leu Gln Ser Glu Gly His Phe Ser Leu Gln Ser
1185                1190                1195                1200
Ser Gln Gly Ser Ser Val Asp Ala Gly Cys Gly Thr Gly Ser Ser Gly
                1205                1210                1215    
Ser Ala Cys Ala Thr Pro Val Glu Ser Pro Leu Cys Pro Ser Leu Gly
            1220                1225                1230        
Lys His Leu Ile Pro Asp Ala Ser Gly Lys Gly Val Asn Tyr Ile Pro
        1235                1240                1245            
Ser Glu Glu Arg Ala Pro Gly Leu Pro Asn His Gly Ala Thr Phe Lys
    1250                1255                1260                
Glu Leu His Pro Gln Thr Glu Gly Met Cys Pro Arg Met Thr Val Pro
1265                1270                1275                1280
Ala Leu His Thr Ala Ile Asn Thr Glu Pro Leu Phe Gly Thr Leu Arg
                1285                1290                1295    
Asp Gly Cys His Arg Leu Pro Lys Ile Lys Glu Thr Thr Val
            1300                1305                1310


<210> 761
<211> 325
<212> PRT
<213> Homo sapiens

<400> 761
Arg Asn Glu Gly Cys Gln Asn Leu Ala Arg Arg Asn Leu Ser Arg Asp
 1               5                  10                  15      
Asn Arg Gln Glu Asn Tyr Gly Ser Ala Phe Pro Gln Gly Gly Glu Asn
            20                  25                  30          
Arg Asn Glu Asn Glu Glu Ser Thr Ser Lys Ala Glu Thr Ser Glu Asp
        35                  40                  45              
Ser Ala Ser Arg Gly Glu Thr Thr Gly Arg Ser Gln Lys Glu Phe Gly
    50                  55                  60                  
Glu Lys Arg Asp Gln Glu Gly Lys Thr Gly Glu Arg Gln Gln Lys Asn
65                  70                  75                  80  
Pro Glu Glu Lys Thr Arg Lys Glu Lys Arg Asp Ser Gly Pro Ala Ile
                85                  90                  95      
Gly Lys Asp Lys Lys Thr Ile Thr Gly Glu Arg Gly Pro Arg Glu Lys
            100                 105                 110         
Gly Lys Gly Leu Gly Arg Ser Phe Ser Leu Ser Ser Asn Phe Thr Thr
        115                 120                 125             
Pro Glu Glu Val Pro Thr Gly Thr Lys Ser His Arg Cys Asp Glu Cys
    130                 135                 140                 
Gly Lys Cys Phe Thr Arg Ser Ser Ser Leu Ile Arg His Lys Ile Ile
145                 150                 155                 160 
His Thr Gly Glu Lys Pro Tyr Glu Cys Ser Glu Cys Gly Lys Ala Phe
                165                 170                 175     
Ser Leu Asn Ser Asn Leu Val Leu His Gln Arg Ile His Thr Gly Glu
            180                 185                 190         
Lys Pro His Glu Cys Asn Glu Cys Gly Lys Ala Phe Ser His Ser Ser
        195                 200                 205             
Asn Leu Ile Leu His Gln Arg Ile His Ser Gly Glu Lys Pro Tyr Glu
    210                 215                 220                 
Cys Asn Glu Cys Gly Lys Ala Phe Ser Gln Ser Ser Asp Leu Thr Lys
225                 230                 235                 240 
His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Ser Glu Cys
                245                 250                 255     
Gly Lys Ala Phe Asn Arg Asn Ser Tyr Leu Ile Leu His Arg Arg Ile
            260                 265                 270         
His Thr Arg Glu Lys Pro Tyr Lys Cys Thr Lys Cys Gly Lys Ala Phe
        275                 280                 285             
Thr Arg Ser Ser Thr Leu Thr Leu His His Arg Ile His Ala Arg Glu
    290                 295                 300                 
Arg Ala Ser Glu Tyr Ser Pro Ala Ser Leu Asp Ala Phe Gly Ala Phe
305                 310                 315                 320 
Leu Lys Ser Cys Val
                325 


<210> 762
<211> 570
<212> PRT
<213> Homo sapiens

<400> 762
Met Ala Ala Arg Arg Arg Arg Ser Thr Gly Gly Gly Arg Ala Arg Ala
 1               5                  10                  15      
Leu Asn Glu Ser Lys Arg Val Asn Asn Gly Asn Thr Ala Pro Glu Asp
            20                  25                  30          
Ser Ser Pro Ala Lys Lys Thr Arg Arg Cys Gln Arg Gln Glu Ser Lys
        35                  40                  45              
Lys Met Pro Val Ala Gly Gly Lys Ala Asn Lys Asp Arg Thr Glu Asp
    50                  55                  60                  
Lys Gln Asp Glu Ser Val Lys Ala Leu Leu Leu Lys Gly Lys Ala Pro
65                  70                  75                  80  
Val Asp Pro Glu Cys Thr Ala Lys Val Gly Lys Ala His Val Tyr Cys
                85                  90                  95      
Glu Gly Asn Asp Val Tyr Asp Val Met Leu Asn Gln Thr Asn Leu Gln
            100                 105                 110         
Phe Asn Asn Asn Lys Tyr Tyr Leu Ile Gln Leu Leu Glu Asp Asp Ala
        115                 120                 125             
Gln Arg Asn Phe Ser Val Trp Met Arg Trp Gly Arg Val Gly Lys Met
    130                 135                 140                 
Gly Gln His Ser Leu Val Ala Cys Ser Gly Asn Leu Asn Lys Ala Lys
145                 150                 155                 160 
Glu Ile Phe Gln Lys Lys Phe Leu Asp Lys Thr Lys Asn Asn Trp Glu
                165                 170                 175     
Asp Arg Glu Lys Phe Glu Lys Val Pro Gly Lys Tyr Asp Met Leu Gln
            180                 185                 190         
Met Asp Tyr Ala Thr Asn Thr Gln Asp Glu Glu Glu Thr Lys Lys Glu
        195                 200                 205             
Glu Ser Leu Lys Ser Pro Leu Lys Pro Glu Ser Gln Leu Asp Leu Arg
    210                 215                 220                 
Val Gln Glu Leu Ile Lys Leu Ile Cys Asn Val Gln Ala Met Glu Glu
225                 230                 235                 240 
Met Met Met Glu Met Lys Tyr Asn Thr Lys Lys Ala Pro Leu Gly Lys
                245                 250                 255     
Leu Thr Val Ala Gln Ile Lys Ala Gly Tyr Gln Ser Leu Lys Lys Ile
            260                 265                 270         
Glu Asp Cys Ile Arg Ala Gly Gln His Gly Arg Ala Leu Met Glu Ala
        275                 280                 285             
Cys Asn Glu Phe Tyr Thr Arg Ile Pro His Asp Phe Gly Leu Arg Thr
    290                 295                 300                 
Pro Pro Leu Ile Arg Thr Gln Lys Glu Leu Ser Glu Lys Ile Gln Leu
305                 310                 315                 320 
Leu Glu Ala Leu Gly Asp Ile Glu Ile Ala Ile Lys Leu Val Lys Thr
                325                 330                 335     
Glu Leu Gln Ser Pro Glu His Pro Leu Asp Gln His Tyr Arg Asn Leu
            340                 345                 350         
His Cys Ala Leu Arg Pro Leu Asp His Glu Ser Tyr Glu Phe Lys Val
        355                 360                 365             
Ile Ser Gln Tyr Leu Gln Ser Thr His Ala Pro Thr His Ser Asp Tyr
    370                 375                 380                 
Thr Met Thr Leu Leu Asp Leu Phe Glu Val Glu Lys Asp Gly Glu Lys
385                 390                 395                 400 
Glu Ala Phe Arg Glu Asp Leu His Asn Arg Met Leu Leu Trp His Gly
                405                 410                 415     
Ser Arg Met Ser Asn Trp Val Gly Ile Leu Ser His Gly Leu Arg Ile
            420                 425                 430         
Ala Pro Pro Glu Ala Pro Ile Thr Gly Tyr Met Phe Gly Lys Gly Ile
        435                 440                 445             
Tyr Phe Ala Asp Met Ser Ser Lys Ser Ala Asn Tyr Cys Phe Ala Ser
    450                 455                 460                 
Arg Leu Lys Asn Thr Gly Leu Leu Leu Leu Ser Glu Val Ala Leu Gly
465                 470                 475                 480 
Gln Cys Asn Glu Leu Leu Glu Ala Asn Pro Lys Ala Glu Gly Leu Leu
                485                 490                 495     
Gln Gly Lys His Ser Thr Lys Gly Leu Gly Lys Met Ala Pro Ser Ser
            500                 505                 510         
Ala His Phe Val Thr Leu Asn Gly Ser Thr Val Pro Leu Gly Pro Ala
        515                 520                 525             
Ser Asp Thr Gly Ile Leu Asn Pro Asp Gly Tyr Thr Leu Asn Tyr Asn
    530                 535                 540                 
Glu Tyr Ile Val Tyr Asn Pro Asn Gln Val Arg Met Arg Tyr Leu Leu
545                 550                 555                 560 
Lys Val Gln Phe Asn Phe Leu Gln Leu Trp
                565                 570 


<210> 763
<211> 380
<212> PRT
<213> Homo sapiens

<400> 763
Lys Ala Ala Ala Ile Gly Ile Asp Leu Gly Thr Thr Tyr Ser Cys Val
 1               5                  10                  15      
Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp Gln Gly
            20                  25                  30          
Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu Arg Leu
        35                  40                  45              
Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Leu Asn Pro Gln Asn Thr
    50                  55                  60                  
Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe Gly Asp Pro Val
65                  70                  75                  80  
Val Gln Ser Asp Met Lys His Trp Pro Phe Gln Val Ile Asn Asp Gly
                85                  90                  95      
Asp Lys Pro Lys Val Gln Val Ser Tyr Lys Gly Glu Thr Lys Ala Phe
            100                 105                 110         
Tyr Pro Glu Glu Ile Ser Ser Met Val Leu Thr Lys Met Lys Glu Ile
        115                 120                 125             
Ala Glu Ala Tyr Leu Gly Tyr Pro Val Thr Asn Ala Val Ile Thr Val
    130                 135                 140                 
Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp Ala Gly
145                 150                 155                 160 
Val Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro Thr Ala
                165                 170                 175     
Ala Ala Ile Ala Tyr Gly Leu Asp Arg Thr Gly Lys Gly Glu Arg Asn
            180                 185                 190         
Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser Ile Leu
        195                 200                 205             
Thr Ile Asp Asp Gly Ile Phe Glu Val Lys Ala Thr Ala Gly Asp Thr
    210                 215                 220                 
His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val Asn His Phe Val
225                 230                 235                 240 
Glu Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Gln Asn Lys Arg
                245                 250                 255     
Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg Thr Leu
            260                 265                 270         
Ser Ser Ser Thr Gln Ala Ser Leu Glu Ile Asp Ser Leu Phe Glu Gly
        275                 280                 285             
Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu Leu Cys
    290                 295                 300                 
Ser Asp Leu Phe Arg Ser Thr Leu Glu Pro Val Glu Lys Ala Leu Arg
305                 310                 315                 320 
Asp Ala Lys Leu Asp Lys Ala Gln Ile His Asp Leu Val Leu Val Gly
                325                 330                 335     
Gly Ser Thr Arg Ile Pro Lys Val Gln Lys Leu Leu Gln Asp Phe Phe
            340                 345                 350         
Asn Gly Arg Asp Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala Val Ala
        355                 360                 365             
Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Met Gly
    370                 375                 380 


<210> 764
<211> 363
<212> PRT
<213> Homo sapiens

<400> 764
Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu
 1               5                  10                  15      
Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe
            20                  25                  30          
Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly
        35                  40                  45              
Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu
    50                  55                  60                  
Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn
65                  70                  75                  80  
Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp
                85                  90                  95      
Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp
            100                 105                 110         
Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys
        115                 120                 125             
Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro
    130                 135                 140                 
Val Leu Ile Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys
145                 150                 155                 160 
Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly
                165                 170                 175     
Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly
            180                 185                 190         
Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu
        195                 200                 205             
Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp
    210                 215                 220                 
Lys Ser Asp Glu Glu Asn Cys Gly Gly Arg Ser Thr Val Arg Phe Ser
225                 230                 235                 240 
Trp Pro Glu Arg Thr Leu Arg Lys Gly Arg Pro His Pro Ala Ala Pro
                245                 250                 255     
Gly Thr Pro Gly Val Arg Leu Ser Gly Pro Ala Ala Leu Pro Ser Ala
            260                 265                 270         
Gln Pro Val Arg Thr Gly Ser Glu Gly Leu Gly Arg Arg Gly Arg Arg
        275                 280                 285             
Gly Arg Gly Arg Glu Ser Arg Ser Val Arg Pro Pro Gly Pro Gly Gly
    290                 295                 300                 
Trp Leu Glu Gly Gly Ala Pro Pro Val Thr Trp Arg Arg Ala Pro Ala
305                 310                 315                 320 
Pro Gly Ala Lys Ala Met Ala Pro Gly Pro Thr Ala Pro Gln Ile Gly
                325                 330                 335     
Asp Ala Gly Asp Arg Ala Leu Pro Leu Arg Pro Val Ile Asp Leu Arg
            340                 345                 350         
Glu Gly Phe Thr Gln Gly Arg Leu Pro Gly Phe
        355                 360             


<210> 765
<211> 411
<212> PRT
<213> Homo sapiens

<400> 765
Phe Val Leu Pro Thr Ala Ala Cys Gln Asp Ala Glu Gln Pro Thr Arg
 1               5                  10                  15      
Tyr Glu Thr Leu Phe Gln Ala Leu Asp Arg Asn Gly Asp Gly Val Val
            20                  25                  30          
Asp Ile Gly Glu Leu Gln Glu Gly Leu Arg Asn Leu Gly Ile Pro Leu
        35                  40                  45              
Gly Gln Asp Ala Glu Glu Lys Ile Phe Thr Thr Gly Asp Val Asn Lys
    50                  55                  60                  
Asp Gly Lys Leu Asp Phe Glu Glu Phe Met Lys Tyr Leu Lys Asp His
65                  70                  75                  80  
Glu Lys Lys Met Lys Leu Ala Phe Lys Ser Leu Asp Lys Asn Asn Asp
                85                  90                  95      
Gly Lys Ile Glu Ala Ser Glu Ile Val Gln Ser Leu Gln Thr Leu Gly
            100                 105                 110         
Leu Thr Ile Ser Glu Gln Gln Ala Glu Leu Ile Leu Gln Ser Ile Asp
        115                 120                 125             
Val Asp Gly Thr Met Thr Val Asp Trp Asn Glu Trp Arg Asp Tyr Phe
    130                 135                 140                 
Leu Phe Asn Pro Val Thr Asp Ile Glu Glu Ile Ile Arg Phe Trp Lys
145                 150                 155                 160 
His Ser Thr Gly Ile Asp Ile Gly Asp Ser Leu Thr Ile Pro Asp Glu
                165                 170                 175     
Phe Thr Glu Asp Glu Lys Lys Ser Gly Gln Trp Trp Arg Gln Leu Leu
            180                 185                 190         
Ala Gly Gly Ile Ala Gly Ala Val Ser Arg Thr Ser Thr Ala Pro Leu
        195                 200                 205             
Asp Arg Leu Lys Ile Met Met Gln Val His Gly Ser Lys Ser Asp Lys
    210                 215                 220                 
Met Asn Ile Phe Gly Gly Phe Arg Gln Met Val Lys Glu Gly Gly Ile
225                 230                 235                 240 
Arg Ser Leu Trp Arg Gly Asn Gly Thr Asn Val Ile Lys Ile Ala Pro
                245                 250                 255     
Glu Thr Ala Val Lys Phe Trp Ala Tyr Glu Gln Tyr Lys Lys Leu Leu
            260                 265                 270         
Thr Glu Glu Gly Gln Lys Ile Gly Thr Phe Glu Arg Phe Ile Ser Gly
        275                 280                 285             
Ser Met Ala Gly Ala Thr Ala Gln Thr Phe Ile Tyr Pro Met Glu Val
    290                 295                 300                 
Met Lys Thr Arg Leu Ala Val Gly Lys Thr Gly Gln Tyr Ser Gly Ile
305                 310                 315                 320 
Tyr Asp Cys Ala Lys Lys Ile Leu Lys His Glu Gly Leu Gly Ala Phe
                325                 330                 335     
Tyr Lys Gly Tyr Val Pro Asn Leu Leu Gly Ile Ile Pro Tyr Ala Gly
            340                 345                 350         
Ile Asp Leu Ala Val Tyr Glu Leu Leu Lys Ser Tyr Trp Leu Asp Asn
        355                 360                 365             
Phe Ala Lys Asp Ser Val Asn Pro Gly Val Met Val Leu Leu Gly Cys
    370                 375                 380                 
Gly Ala Leu Ser Ser Thr Cys Gly Gln Leu Ala Ser Tyr Pro Leu Ala
385                 390                 395                 400 
Leu Val Arg Thr Arg Met Gln Ala Gln Ala Cys
                405                 410     


<210> 766
<211> 393
<212> PRT
<213> Homo sapiens

<400> 766
Met Ala Lys Ser Pro Glu Asn Ser Thr Leu Glu Glu Ile Leu Gly Gln
 1               5                  10                  15      
Tyr Gln Arg Ser Leu Arg Glu His Ala Ser Arg Ser Ile His Gln Leu
            20                  25                  30          
Thr Cys Ala Leu Lys Glu Gly Asp Val Thr Ile Gly Glu Asp Ala Pro
        35                  40                  45              
Asn Leu Ser Phe Ser Thr Ser Val Gly Asn Glu Asp Ala Arg Thr Ala
    50                  55                  60                  
Trp Pro Glu Leu Gln Gln Ser His Ala Val Asn Gln Leu Lys Asp Leu
65                  70                  75                  80  
Leu Arg Gln Gln Ala Asp Lys Glu Ser Glu Val Ser Pro Ser Arg Arg
                85                  90                  95      
Arg Lys Met Ser Pro Leu Arg Ser Leu Glu His Glu Glu Thr Asn Met
            100                 105                 110         
Pro Thr Met His Asp Leu Val His Thr Ile Asn Asp Gln Ser Gln Tyr
        115                 120                 125             
Ile His His Leu Glu Ala Glu Val Lys Phe Cys Lys Glu Glu Leu Ser
    130                 135                 140                 
Gly Met Lys Asn Lys Ile Gln Val Val Val Leu Glu Asn Glu Gly Leu
145                 150                 155                 160 
Gln Gln Gln Leu Lys Ser Gln Arg Gln Glu Glu Thr Leu Arg Glu Gln
                165                 170                 175     
Thr Leu Leu Asp Ala Ser Gly Asn Met His Asn Ser Trp Ile Thr Thr
            180                 185                 190         
Gly Glu Asp Ser Gly Val Gly Glu Thr Ser Lys Arg Pro Phe Ser His
        195                 200                 205             
Asp Asn Ala Asp Phe Gly Lys Ala Ala Ser Ala Gly Glu Gln Leu Glu
    210                 215                 220                 
Leu Glu Lys Leu Lys Leu Thr Tyr Glu Glu Lys Cys Glu Ile Glu Glu
225                 230                 235                 240 
Ser Gln Leu Lys Phe Leu Arg Asn Asp Leu Ala Glu Tyr Gln Arg Thr
                245                 250                 255     
Cys Glu Asp Leu Lys Glu Gln Leu Lys His Lys Glu Phe Leu Leu Ala
            260                 265                 270         
Ala Asn Thr Cys Asn Arg Val Gly Gly Leu Cys Leu Lys Cys Ala Gln
        275                 280                 285             
His Glu Ala Val Leu Ser Gln Thr His Thr Asn Val His Met Gln Thr
    290                 295                 300                 
Ile Glu Arg Leu Val Lys Glu Arg Asp Asp Leu Met Ser Ala Leu Val
305                 310                 315                 320 
Ser Val Arg Ser Ser Leu Ala Asp Thr Gln Gln Arg Glu Ala Ser Ala
                325                 330                 335     
Tyr Glu Gln Val Lys Gln Val Leu Gln Ile Ser Glu Glu Ala Asn Phe
            340                 345                 350         
Glu Lys Thr Lys Ala Leu Ile Gln Cys Asp Gln Leu Arg Lys Glu Leu
        355                 360                 365             
Glu Arg Gln Ala Glu Arg Leu Glu Lys Glu Leu Ala Ser Gln Gln Glu
    370                 375                 380                 
Lys Arg Ala Ile Glu Lys Asp Met Met
385                 390             


<210> 767
<211> 2011
<212> PRT
<213> Homo sapiens

<400> 767
Ala Arg Gly Gly Asp Glu Asp Asp Asp Asp Asp Gly Ser Glu Met Glu
 1               5                  10                  15      
Leu Asp Glu Asp Tyr Pro Asp Met Asn Ala Ser Pro Leu Val Arg Phe
            20                  25                  30          
Glu Arg Phe Asp Arg Glu Asp Asp Leu Ile Ile Glu Phe Asp Asn Met
        35                  40                  45              
Phe Ser Ser Ala Thr Asp Ile Pro Pro Ser Pro Gly Asn Ile Pro Thr
    50                  55                  60                  
Thr His Pro Leu Met Val Arg His Ala Asp Tyr Ser Ser Leu Thr Leu
65                  70                  75                  80  
Gly Ser Gly Ser Ser Thr Thr Arg Leu Thr Gln Gly Ile Gly Arg Ser
                85                  90                  95      
Gln Arg Thr Leu Arg Gln Leu Thr Ala Asn Thr Gly His Thr Ile His
            100                 105                 110         
Val His Tyr Pro Gly Asn Arg Gln Pro Asn Pro Pro Leu Ile Leu Gln
        115                 120                 125             
Arg Leu Leu Gly Pro Ser Ala Ala Ala Asp Ile Leu Gln Leu Ser Ser
    130                 135                 140                 
Ser Leu Pro Leu Gln Ser Arg Gly Arg Ala Arg Leu Leu Val Gly Asn
145                 150                 155                 160 
Asp Asp Val His Ile Ile Ala Arg Ser Asp Asp Glu Leu Leu Asp Asp
                165                 170                 175     
Phe Phe His Asp Gln Ser Thr Ala Thr Ser Gln Ala Gly Thr Leu Ser
            180                 185                 190         
Ser Ile Pro Thr Ala Leu Thr Arg Trp Thr Glu Glu Cys Lys Val Leu
        195                 200                 205             
Asp Ala Glu Ser Met His Asp Cys Val Ser Val Val Lys Val Ser Ile
    210                 215                 220                 
Val Asn His Leu Glu Phe Leu Arg Asp Glu Glu Leu Glu Glu Arg Arg
225                 230                 235                 240 
Glu Lys Arg Arg Lys Gln Leu Ala Glu Glu Glu Thr Lys Ile Thr Asp
                245                 250                 255     
Lys Gly Lys Glu Asp Lys Glu Asn Arg Asp Gln Ser Ala Gln Cys Thr
            260                 265                 270         
Ala Ser Lys Ser Asn Asp Ser Thr Glu Gln Asn Leu Ser Asp Gly Thr
        275                 280                 285             
Pro Met Pro Asp Ser Tyr Pro Thr Thr Pro Ser Ser Thr Asp Ala Ala
    290                 295                 300                 
Thr Ser Glu Ser Lys Glu Thr Leu Gly Thr Leu Gln Ser Ser Gln Gln
305                 310                 315                 320 
Gln Pro Thr Leu Pro Thr Pro Pro Ala Leu Gly Glu Val Pro Gln Glu
                325                 330                 335     
Leu Gln Ser Pro Ala Gly Glu Gly Gly Ser Ser Thr Gln Leu Leu Met
            340                 345                 350         
Pro Val Glu Pro Glu Glu Leu Gly Pro Thr Arg Pro Ser Gly Glu Ala
        355                 360                 365             
Glu Thr Thr Gln Met Glu Leu Ser Pro Ala Pro Thr Ile Thr Ser Leu
    370                 375                 380                 
Ser Pro Glu Arg Ala Glu Asp Ser Asp Ala Leu Thr Ala Val Ser Ser
385                 390                 395                 400 
Gln Leu Glu Gly Ser Pro Met Asp Thr Ser Ser Leu Ala Ser Cys Thr
                405                 410                 415     
Leu Glu Glu Ala Val Gly Asp Thr Ser Ala Ala Gly Ser Ser Glu Gln
            420                 425                 430         
Pro Arg Ala Gly Ser Ser Thr Pro Gly Asp Ala Pro Pro Ala Val Ala
        435                 440                 445             
Glu Val Gln Gly Arg Ser Asp Gly Ser Gly Glu Ser Ala Gln Pro Pro
    450                 455                 460                 
Glu Asp Ser Ser Pro Pro Ala Ser Ser Glu Ser Ser Ser Thr Arg Asp
465                 470                 475                 480 
Ser Ala Val Ala Ile Ser Gly Ala Asp Ser Arg Gly Ile Leu Glu Glu
                485                 490                 495     
Pro Leu Pro Ser Thr Ser Ser Glu Glu Glu Asp Pro Leu Ala Gly Ile
            500                 505                 510         
Ser Leu Pro Glu Gly Val Asp Pro Ser Phe Leu Ala Ala Leu Pro Asp
        515                 520                 525             
Asp Ile Arg Arg Glu Val Leu Gln Asn Gln Leu Gly Ile Arg Pro Pro
    530                 535                 540                 
Thr Arg Thr Ala Pro Ser Thr Asn Ser Ser Ala Pro Ala Val Val Gly
545                 550                 555                 560 
Asn Pro Gly Val Thr Glu Val Ser Pro Glu Phe Leu Ala Ala Leu Pro
                565                 570                 575     
Pro Ala Ile Gln Glu Glu Val Leu Ala Gln Gln Arg Ala Glu Gln Gln
            580                 585                 590         
Arg Arg Glu Leu Ala Gln Asn Ala Ser Ser Asp Thr Pro Met Asp Pro
        595                 600                 605             
Val Thr Phe Ile Gln Thr Leu Pro Ser Asp Leu Arg Arg Ser Val Leu
    610                 615                 620                 
Glu Asp Met Glu Asp Ser Val Leu Ala Val Met Pro Pro Asp Ile Ala
625                 630                 635                 640 
Ala Glu Ala Gln Ala Leu Arg Arg Glu Gln Glu Ala Arg Gln Arg Gln
                645                 650                 655     
Leu Met His Glu Arg Leu Phe Gly His Ser Ser Thr Ser Ala Leu Ser
            660                 665                 670         
Ala Ile Leu Arg Ser Pro Ala Phe Thr Ser Arg Leu Ser Gly Asn Arg
        675                 680                 685             
Gly Val Gln Tyr Thr Arg Leu Ala Val Gln Arg Gly Gly Thr Phe Gln
    690                 695                 700                 
Met Gly Gly Ser Ser Ser His Asn Arg Pro Ser Gly Ser Asn Val Asp
705                 710                 715                 720 
Thr Leu Leu Arg Leu Arg Gly Arg Leu Leu Leu Asp His Glu Ala Leu
                725                 730                 735     
Ser Cys Leu Leu Val Leu Leu Phe Val Asp Glu Pro Lys Leu Asn Thr
            740                 745                 750         
Ser Arg Leu His Arg Val Leu Arg Asn Leu Cys Tyr His Ala Gln Thr
        755                 760                 765             
Arg His Trp Val Ile Arg Ser Leu Leu Ser Ile Leu Gln Arg Ser Ser
    770                 775                 780                 
Glu Ser Glu Leu Cys Ile Glu Thr Pro Lys Leu Thr Thr Ser Glu Glu
785                 790                 795                 800 
Lys Gly Lys Lys Ser Ser Lys Ser Cys Gly Ser Ser Ser His Glu Asn
                805                 810                 815     
Arg Pro Leu Asp Leu Leu His Lys Met Glu Ser Lys Ser Ser Asn Gln
            820                 825                 830         
Leu Ser Trp Leu Ser Val Ser Met Asp Ala Ala Leu Gly Cys Arg Thr
        835                 840                 845             
Asn Ile Phe Gln Ile Gln Arg Ser Gly Gly Arg Lys His Thr Glu Lys
    850                 855                 860                 
His Ala Ser Gly Gly Ser Thr Val His Ile His Pro Gln Ala Ala Pro
865                 870                 875                 880 
Val Val Cys Arg His Val Leu Asp Thr Leu Ile Gln Leu Ala Lys Val
                885                 890                 895     
Phe Pro Ser His Phe Thr Gln Gln Arg Thr Lys Glu Thr Asn Cys Glu
            900                 905                 910         
Ser Asp Arg Glu Arg Gly Asn Lys Ala Cys Ser Pro Cys Ser Ser Gln
        915                 920                 925             
Ser Ser Ser Ser Gly Ile Cys Thr Asp Phe Trp Asp Leu Leu Val Lys
    930                 935                 940                 
Leu Asp Asn Met Asn Val Ser Arg Lys Gly Lys Asn Ser Val Lys Ser
945                 950                 955                 960 
Val Pro Val Ser Ala Gly Gly Glu Gly Glu Thr Ser Pro Tyr Ser Leu
                965                 970                 975     
Glu Ala Ser Pro Leu Gly Gln Leu Met Asn Met Leu Ser His Pro Val
            980                 985                 990         
Ile Arg Arg Ser Ser Leu Leu Thr Glu Lys Leu Leu Arg Leu Leu Ser
        995                 1000                1005            
Leu Ile Ser Ile Ala Leu Pro Glu Asn Lys Val Ser Glu Ala Gln Ala
    1010                1015                1020                
Asn Ser Gly Ser Gly Ala Ser Ser Thr Thr Thr Ala Thr Ser Thr Thr
1025                1030                1035                1040
Ser Thr Thr Thr Thr Thr Ala Ala Ser Thr Thr Pro Thr Pro Pro Thr
                1045                1050                1055    
Ala Pro Thr Pro Val Thr Ser Ala Pro Ala Leu Val Ala Ala Thr Ala
            1060                1065                1070        
Ile Ser Thr Ile Val Val Ala Ala Ser Thr Thr Val Thr Thr Pro Thr
        1075                1080                1085            
Thr Ala Thr Thr Thr Val Ser Ile Ser Pro Thr Thr Lys Gly Ser Lys
    1090                1095                1100                
Ser Pro Ala Lys Val Ser Asp Gly Gly Ser Ser Ser Thr Asp Phe Lys
1105                1110                1115                1120
Met Val Ser Ser Gly Leu Thr Glu Asn Gln Leu Gln Leu Ser Val Glu
                1125                1130                1135    
Val Leu Thr Ser His Ser Cys Ser Glu Glu Gly Leu Glu Asp Ala Ala
            1140                1145                1150        
Asn Val Leu Leu Gln Leu Ser Arg Gly Asp Ser Gly Thr Arg Asp Thr
        1155                1160                1165            
Val Leu Lys Leu Leu Leu Asn Gly Ala Arg His Leu Gly Tyr Thr Leu
    1170                1175                1180                
Cys Lys Gln Ile Gly Thr Leu Leu Ala Glu Leu Arg Glu Tyr Asn Leu
1185                1190                1195                1200
Glu Gln Gln Arg Arg Ala Gln Cys Glu Thr Leu Ser Pro Asp Gly Leu
                1205                1210                1215    
Pro Glu Glu Gln Pro Gln Thr Thr Lys Leu Lys Gly Lys Met Gln Ser
            1220                1225                1230        
Arg Phe Asp Met Ala Glu Asn Val Val Ile Val Ala Ser Gln Lys Arg
        1235                1240                1245            
Pro Leu Gly Gly Arg Glu Leu Gln Leu Pro Ser Met Ser Met Leu Thr
    1250                1255                1260                
Ser Lys Thr Ser Thr Gln Lys Phe Phe Leu Arg Val Leu Gln Val Ile
1265                1270                1275                1280
Ile Gln Leu Arg Asp Asp Thr Arg Arg Ala Asn Lys Lys Ala Lys Gln
                1285                1290                1295    
Thr Gly Arg Leu Gly Ser Ser Gly Leu Gly Ser Ala Ser Ser Ile Gln
            1300                1305                1310        
Ala Ala Val Arg Gln Leu Glu Ala Glu Ala Asp Ala Ile Ile Gln Met
        1315                1320                1325            
Val Arg Glu Gly Gln Arg Ala Arg Arg Gln Gln Gln Ala Ala Thr Ser
    1330                1335                1340                
Glu Ser Ser Gln Ser Glu Ala Ser Val Arg Arg Glu Glu Ser Pro Met
1345                1350                1355                1360
Asp Val Asp Gln Pro Ser Pro Ser Ala Gln Asp Thr Gln Ser Ile Ala
                1365                1370                1375    
Ser Asp Gly Thr Pro Gln Gly Glu Lys Glu Lys Glu Glu Arg Pro Pro
            1380                1385                1390        
Glu Leu Pro Leu Leu Ser Glu Gln Leu Ser Leu Asp Glu Leu Trp Asp
        1395                1400                1405            
Met Leu Gly Glu Cys Leu Lys Glu Leu Glu Glu Ser His Asp Gln His
    1410                1415                1420                
Ala Val Leu Val Leu Gln Pro Ala Val Glu Ala Phe Phe Leu Val His
1425                1430                1435                1440
Ala Thr Glu Arg Glu Ser Lys Pro Pro Val Arg Asp Thr Arg Glu Ser
                1445                1450                1455    
Gln Leu Ala His Ile Lys Asp Glu Pro Pro Pro Leu Ser Pro Ala Pro
            1460                1465                1470        
Leu Thr Pro Ala Thr Pro Ser Ser Leu Asp Pro Phe Phe Ser Arg Glu
        1475                1480                1485            
Pro Ser Ser Met His Ile Ser Ser Ser Leu Pro Pro Asp Thr Gln Lys
    1490                1495                1500                
Phe Leu Arg Phe Ala Glu Thr His Arg Thr Val Leu Asn Gln Ile Leu
1505                1510                1515                1520
Arg Gln Ser Thr Thr His Leu Ala Asp Gly Pro Phe Ala Val Leu Val
                1525                1530                1535    
Asp Tyr Ile Arg Val Leu Asp Phe Asp Val Lys Arg Lys Tyr Phe Arg
            1540                1545                1550        
Gln Glu Leu Glu Arg Leu Asp Glu Gly Leu Arg Lys Glu Asp Met Ala
        1555                1560                1565            
Val His Val Arg Arg Asp His Val Phe Glu Asp Ser Tyr Arg Glu Leu
    1570                1575                1580                
His Arg Lys Ser Pro Glu Glu Met Lys Asn Arg Leu Tyr Ile Val Phe
1585                1590                1595                1600
Glu Gly Glu Glu Gly Gln Asp Ala Gly Gly Leu Leu Arg Glu Trp Tyr
                1605                1610                1615    
Met Ile Ile Ser Arg Glu Met Phe Asn Pro Met Tyr Ala Leu Phe Arg
            1620                1625                1630        
Thr Ser Pro Gly Asp Arg Val Thr Tyr Thr Ile Asn Pro Ser Ser His
        1635                1640                1645            
Cys Asn Pro Asn His Leu Ser Tyr Phe Lys Phe Val Gly Arg Ile Val
    1650                1655                1660                
Ala Lys Ala Val Tyr Asp Asn Arg Leu Leu Glu Cys Tyr Phe Thr Arg
1665                1670                1675                1680
Ser Phe Tyr Lys His Ile Leu Gly Lys Ser Val Arg Tyr Thr Asp Met
                1685                1690                1695    
Glu Ser Glu Asp Tyr His Phe Tyr Gln Gly Leu Val Tyr Leu Leu Glu
            1700                1705                1710        
Asn Asp Val Ser Thr Leu Gly Tyr Asp Leu Thr Phe Ser Thr Glu Val
        1715                1720                1725            
Gln Glu Phe Gly Val Cys Glu Val Arg Asp Leu Lys Pro Asn Gly Ala
    1730                1735                1740                
Asn Ile Leu Val Thr Glu Glu Asn Lys Lys Glu Tyr Val His Leu Val
1745                1750                1755                1760
Cys Gln Met Arg Met Thr Gly Ala Ile Arg Lys Gln Leu Ala Ala Phe
                1765                1770                1775    
Leu Glu Gly Phe Tyr Glu Ile Ile Pro Lys Arg Leu Ile Ser Ile Phe
            1780                1785                1790        
Thr Glu Gln Glu Leu Glu Leu Leu Ile Ser Gly Leu Pro Thr Ile Asp
        1795                1800                1805            
Ile Asp Asp Leu Lys Ser Asn Thr Glu Tyr His Lys Tyr Gln Ser Asn
    1810                1815                1820                
Ser Ile Gln Ile Gln Trp Phe Trp Arg Ala Leu Arg Ser Phe Asp Gln
1825                1830                1835                1840
Ala Asp Arg Ala Lys Phe Leu Gln Phe Val Thr Gly Thr Ser Lys Val
                1845                1850                1855    
Pro Leu Gln Gly Phe Ala Ala Leu Glu Gly Met Asn Gly Ile Gln Lys
            1860                1865                1870        
Phe Gln Ile His Arg Asp Asp Arg Ser Thr Asp Arg Leu Pro Ser Ala
        1875                1880                1885            
His Thr Cys Phe Asn Gln Leu Asp Leu Pro Ala Tyr Glu Ser Phe Glu
    1890                1895                1900                
Lys Ser Ala Thr Cys Tyr Cys Trp Leu Ser Arg Ser Ala Leu Lys Ala
1905                1910                1915                1920
Leu Gly Trp Pro Asn Lys Ala Leu Pro Asn Ser Val Gly Phe Phe Leu
                1925                1930                1935    
Pro Leu Leu Asp Leu Gly Arg Gly Glu Leu Lys Lys Glu Pro Glu Arg
            1940                1945                1950        
Asn Cys Gln Lys Pro Ile Asn Glu Ile His Gln Leu Thr Val Cys Val
        1955                1960                1965            
Pro Ala Ala Pro Ser Ser Pro Ala His Thr Cys Ser Ser Ser His Ser
    1970                1975                1980                
Leu Pro Ala Ala Cys Phe Leu Thr Phe Ser Pro Leu Ser Met Pro Ser
1985                1990                1995                2000
Met Ile Pro Thr Pro Cys Val Leu Lys Arg Gln
                2005                2010    


<210> 768
<211> 342
<212> PRT
<213> Homo sapiens

<400> 768
Met Arg Gly Ser Leu Leu Ala Ser Gly Arg Ala Cys Arg Ala Ser Ser
 1               5                  10                  15      
Gly Leu Pro Arg Asn Thr Val Val Leu Phe Val Pro Gln Gln Glu Ala
            20                  25                  30          
Trp Val Val Glu Arg Met Gly Arg Phe His Arg Ile Leu Glu Pro Gly
        35                  40                  45              
Leu Asn Ile Leu Ile Pro Val Leu Asp Arg Ile Arg Tyr Val Gln Ser
    50                  55                  60                  
Leu Lys Glu Ile Val Ile Asn Val Pro Glu Gln Ser Ala Val Thr Leu
65                  70                  75                  80  
Asp Asn Val Thr Leu Gln Ile Asp Gly Val Leu Tyr Leu Arg Ile Met
                85                  90                  95      
Asp Pro Tyr Lys Ala Ser Tyr Gly Val Glu Asp Pro Glu Tyr Ala Val
            100                 105                 110         
Thr Gln Leu Ala Gln Thr Thr Met Arg Ser Glu Leu Gly Lys Leu Ser
        115                 120                 125             
Leu Asp Lys Val Phe Arg Glu Arg Glu Ser Leu Asn Ala Ser Ile Val
    130                 135                 140                 
Asp Ala Ile Asn Gln Ala Ala Asp Cys Trp Gly Ile Arg Cys Leu Arg
145                 150                 155                 160 
Tyr Glu Ile Lys Asp Ile His Val Pro Pro Arg Val Lys Glu Ser Met
                165                 170                 175     
Gln Met Gln Val Glu Ala Glu Arg Arg Lys Arg Pro Thr Val Leu Glu
            180                 185                 190         
Ser Glu Gly Thr Arg Glu Ser Ala Ile Asn Val Ala Glu Gly Lys Lys
        195                 200                 205             
Gln Ala Gln Ile Leu Ala Ser Glu Ala Glu Lys Ala Glu Gln Ile Asn
    210                 215                 220                 
Gln Ala Ala Gly Glu Ala Ser Ala Val Leu Ala Lys Ala Lys Ala Lys
225                 230                 235                 240 
Ala Glu Ala Ile Arg Ile Leu Ala Ala Ala Leu Thr Gln His Asn Gly
                245                 250                 255     
Asp Ala Ala Ala Ser Leu Thr Val Ala Glu Gln Tyr Val Ser Ala Phe
            260                 265                 270         
Ser Lys Leu Ala Lys Asp Ser Asn Thr Ile Leu Leu Pro Ser Asn Pro
        275                 280                 285             
Gly Asp Val Thr Ser Met Val Ala Gln Ala Met Gly Val Tyr Gly Ala
    290                 295                 300                 
Leu Thr Lys Ala Pro Val Pro Gly Thr Pro Asp Ser Leu Ser Ser Gly
305                 310                 315                 320 
Ser Ser Arg Asp Val Gln Gly Thr Asp Ala Ser Leu Asp Glu Glu Leu
                325                 330                 335     
Asp Arg Val Lys Met Ser
            340         


<210> 769
<211> 21
<212> PRT
<213> Homo sapiens

<400> 769
Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser Arg Thr Gln Gly
 1               5                  10                  15      
His Glu Gln Tyr Phe
            20      


<210> 770
<211> 214
<212> PRT
<213> Homo sapiens

<400> 770
Met Gly Leu Ala Gly Val Cys Ala Leu Arg Arg Ser Ala Gly Tyr Ile
 1               5                  10                  15      
Leu Val Gly Gly Ala Gly Gly Gln Ser Ala Ala Ala Ala Ala Arg Arg
            20                  25                  30          
Cys Ser Glu Gly Glu Trp Ala Ser Gly Gly Val Arg Ser Phe Ser Arg
        35                  40                  45              
Ala Ala Ala Ala Met Ala Pro Ile Lys Val Gly Asp Ala Ile Pro Ala
    50                  55                  60                  
Val Glu Val Phe Glu Gly Glu Pro Gly Asn Lys Val Asn Leu Ala Glu
65                  70                  75                  80  
Leu Phe Lys Gly Lys Lys Gly Val Leu Phe Gly Val Pro Gly Ala Phe
                85                  90                  95      
Thr Pro Gly Cys Ser Lys Thr His Leu Pro Gly Phe Val Glu Gln Ala
            100                 105                 110         
Glu Ala Leu Lys Ala Lys Gly Val Gln Val Val Ala Cys Leu Ser Val
        115                 120                 125             
Asn Asp Ala Phe Val Thr Gly Glu Trp Gly Arg Ala His Lys Ala Glu
    130                 135                 140                 
Gly Lys Val Arg Leu Leu Ala Asp Pro Thr Gly Ala Phe Gly Lys Glu
145                 150                 155                 160 
Thr Asp Leu Leu Leu Asp Asp Ser Leu Val Ser Ile Phe Gly Asn Arg
                165                 170                 175     
Arg Leu Lys Arg Phe Ser Met Val Val Gln Asp Gly Ile Val Lys Ala
            180                 185                 190         
Leu Asn Val Glu Pro Asp Gly Thr Gly Leu Thr Cys Ser Leu Ala Pro
        195                 200                 205             
Asn Ile Ile Ser Gln Leu
    210                 


<210> 771
<211> 1376
<212> PRT
<213> Homo sapiens

<400> 771
Met Ala Leu Lys Asn Ile Asn Tyr Leu Leu Ile Phe Tyr Leu Ser Phe
 1               5                  10                  15      
Ser Leu Leu Ile Tyr Ile Lys Asn Ser Phe Cys Asn Lys Asn Asn Thr
            20                  25                  30          
Arg Cys Leu Ser Asn Ser Cys Gln Asn Asn Ser Thr Cys Lys Asp Phe
        35                  40                  45              
Ser Lys Asp Asn Asp Cys Ser Cys Ser Asp Thr Ala Asn Asn Leu Asp
    50                  55                  60                  
Lys Asp Cys Asp Asn Met Lys Asp Pro Cys Phe Ser Asn Pro Cys Gln
65                  70                  75                  80  
Gly Ser Ala Thr Cys Val Asn Thr Pro Gly Glu Arg Ser Phe Leu Cys
                85                  90                  95      
Lys Cys Pro Pro Gly Tyr Ser Gly Thr Ile Cys Glu Thr Thr Ile Gly
            100                 105                 110         
Ser Cys Gly Lys Asn Ser Cys Gln His Gly Gly Ile Cys His Gln Asp
        115                 120                 125             
Pro Ile Tyr Pro Val Cys Ile Cys Pro Ala Gly Tyr Ala Gly Arg Phe
    130                 135                 140                 
Cys Glu Ile Asp His Asp Glu Cys Ala Ser Ser Pro Cys Gln Asn Gly
145                 150                 155                 160 
Ala Val Cys Gln Asp Gly Ile Asp Gly Tyr Ser Cys Phe Cys Val Pro
                165                 170                 175     
Gly Tyr Gln Gly Arg His Cys Asp Leu Glu Val Asp Glu Cys Ala Ser
            180                 185                 190         
Asp Pro Cys Lys Asn Glu Ala Thr Cys Leu Asn Glu Ile Gly Arg Tyr
        195                 200                 205             
Thr Cys Ile Cys Pro His Asn Tyr Ser Gly Val Asn Cys Glu Leu Glu
    210                 215                 220                 
Ile Asp Glu Cys Trp Ser Gln Pro Cys Leu Asn Gly Ala Thr Cys Gln
225                 230                 235                 240 
Asp Ala Leu Gly Ala Tyr Phe Cys Asp Cys Ala Pro Gly Phe Leu Gly
                245                 250                 255     
Asp His Cys Glu Leu Asn Thr Asp Glu Cys Ala Ser Gln Pro Cys Leu
            260                 265                 270         
His Gly Gly Leu Cys Val Asp Gly Glu Asn Arg Tyr Ser Cys Asn Cys
        275                 280                 285             
Thr Gly Ser Gly Phe Thr Gly Thr His Cys Glu Thr Leu Met Pro Leu
    290                 295                 300                 
Cys Trp Ser Lys Pro Cys His Asn Asn Ala Thr Cys Glu Asp Ser Val
305                 310                 315                 320 
Asp Asn Tyr Thr Cys His Cys Trp Pro Gly Tyr Thr Gly Ala Gln Cys
                325                 330                 335     
Glu Ile Asp Leu Asn Glu Cys Asn Ser Asn Pro Cys Gln Ser Asn Gly
            340                 345                 350         
Glu Cys Val Glu Leu Ser Ser Glu Lys Gln Tyr Gly Arg Ile Thr Gly
        355                 360                 365             
Leu Pro Ser Ser Phe Ser Tyr His Glu Ala Ser Gly Tyr Val Cys Ile
    370                 375                 380                 
Cys Gln Pro Gly Phe Thr Gly Ile His Cys Glu Glu Asp Val Asn Glu
385                 390                 395                 400 
Cys Ser Ser Asn Pro Cys Gln Asn Gly Gly Thr Cys Glu Asn Leu Pro
                405                 410                 415     
Gly Asn Tyr Thr Cys His Cys Pro Phe Asp Asn Leu Ser Arg Thr Phe
            420                 425                 430         
Tyr Gly Gly Arg Asp Cys Ser Asp Ile Leu Leu Gly Cys Thr His Gln
        435                 440                 445             
Gln Cys Leu Asn Asn Gly Thr Cys Ile Pro His Phe Gln Asp Gly Gln
    450                 455                 460                 
His Gly Phe Ser Cys Leu Cys Pro Ser Gly Tyr Thr Gly Ser Leu Cys
465                 470                 475                 480 
Glu Ile Ala Thr Thr Leu Ser Phe Glu Gly Asp Gly Phe Leu Trp Val
                485                 490                 495     
Lys Ser Gly Ser Val Thr Thr Lys Gly Ser Val Cys Asn Ile Ala Leu
            500                 505                 510         
Arg Phe Gln Thr Val Gln Pro Met Ala Leu Leu Leu Phe Arg Ser Asn
        515                 520                 525             
Arg Asp Val Phe Val Lys Leu Glu Leu Leu Ser Gly Tyr Ile His Leu
    530                 535                 540                 
Ser Ile Gln Val Asn Asn Gln Ser Lys Val Leu Leu Phe Ile Ser His
545                 550                 555                 560 
Asn Thr Ser Asp Gly Glu Trp His Phe Val Glu Val Ile Phe Ala Glu
                565                 570                 575     
Ala Val Thr Leu Thr Leu Ile Asp Asp Ser Cys Lys Glu Lys Cys Ile
            580                 585                 590         
Ala Lys Ala Pro Thr Pro Leu Glu Ser Asp Gln Ser Ile Cys Ala Phe
        595                 600                 605             
Gln Asn Ser Phe Leu Gly Gly Leu Pro Val Gly Met Thr Ser Asn Gly
    610                 615                 620                 
Val Ala Leu Leu Asn Phe Tyr Asn Met Pro Ser Thr Pro Ser Phe Val
625                 630                 635                 640 
Gly Cys Leu Gln Asp Ile Lys Ile Asp Trp Asn His Ile Thr Leu Glu
                645                 650                 655     
Asn Ile Ser Ser Gly Ser Ser Leu Asn Val Lys Ala Gly Cys Val Arg
            660                 665                 670         
Lys Asp Trp Cys Glu Ser Gln Pro Cys Gln Ser Arg Gly Arg Cys Ile
        675                 680                 685             
Asn Leu Trp Leu Ser Tyr Gln Cys Asp Cys His Arg Pro Tyr Glu Gly
    690                 695                 700                 
Pro Asn Cys Leu Arg Glu Tyr Val Ala Gly Arg Phe Gly Gln Asp Asp
705                 710                 715                 720 
Ser Thr Gly Tyr Val Ile Phe Thr Leu Asp Glu Ser Tyr Gly Asp Thr
                725                 730                 735     
Ile Ser Leu Ser Met Phe Val Arg Thr Leu Gln Pro Ser Gly Leu Leu
            740                 745                 750         
Leu Ala Leu Glu Asn Ser Thr Tyr Gln Tyr Ile Arg Val Trp Leu Glu
        755                 760                 765             
Arg Gly Arg Leu Ala Met Leu Thr Pro Asn Ser Pro Lys Leu Val Val
    770                 775                 780                 
Lys Phe Val Leu Asn Asp Gly Asn Val His Leu Ile Ser Leu Lys Ile
785                 790                 795                 800 
Lys Pro Tyr Lys Ile Glu Leu Tyr Gln Ser Ser Gln Asn Leu Gly Phe
                805                 810                 815     
Ile Ser Ala Ser Thr Trp Lys Ile Glu Lys Gly Asp Val Ile Tyr Ile
            820                 825                 830         
Gly Gly Leu Pro Asp Lys Gln Glu Thr Glu Leu Asn Gly Gly Phe Phe
        835                 840                 845             
Lys Gly Cys Ile Gln Asp Val Arg Leu Asn Asn Gln Asn Leu Glu Phe
    850                 855                 860                 
Phe Pro Asn Pro Thr Asn Asn Ala Ser Leu Asn Pro Val Leu Val Asn
865                 870                 875                 880 
Val Thr Gln Gly Cys Ala Gly Asp Asn Ser Cys Lys Ser Asn Pro Cys
                885                 890                 895     
His Asn Gly Gly Val Cys His Ser Arg Trp Asp Asp Phe Ser Cys Ser
            900                 905                 910         
Cys Pro Ala Leu Thr Ser Gly Lys Ala Cys Glu Glu Val Gln Trp Cys
        915                 920                 925             
Gly Phe Ser Pro Cys Pro His Gly Ala Gln Cys Gln Pro Val Leu Gln
    930                 935                 940                 
Gly Phe Glu Cys Ile Ala Asn Ala Val Phe Asn Gly Gln Ser Gly Gln
945                 950                 955                 960 
Ile Leu Phe Arg Ser Asn Gly Asn Ile Thr Arg Glu Leu Thr Asn Ile
                965                 970                 975     
Thr Phe Gly Phe Arg Thr Arg Asp Ala Asn Val Ile Ile Leu His Ala
            980                 985                 990         
Glu Lys Glu Pro Glu Phe Leu Asn Ile Ser Ile Gln Asp Ser Arg Leu
        995                 1000                1005            
Phe Phe Gln Leu Gln Ser Gly Asn Ser Phe Tyr Met Leu Ser Leu Thr
    1010                1015                1020                
Ser Leu Gln Ser Val Asn Asp Gly Thr Trp His Glu Val Thr Leu Ser
1025                1030                1035                1040
Met Thr Asp Pro Leu Ser Gln Thr Ser Arg Trp Gln Met Glu Val Asp
                1045                1050                1055    
Asn Glu Thr Pro Phe Val Thr Ser Thr Ile Ala Thr Gly Ser Leu Asn
            1060                1065                1070        
Phe Leu Lys Asp Asn Thr Asp Ile Tyr Val Gly Asp Arg Ala Ile Asp
        1075                1080                1085            
Asn Ile Lys Gly Leu Gln Gly Cys Leu Ser Thr Ile Glu Ile Gly Gly
    1090                1095                1100                
Ile Tyr Leu Ser Tyr Phe Glu Asn Val His Gly Phe Ile Asn Lys Pro
1105                1110                1115                1120
Gln Glu Glu Gln Phe Leu Lys Ile Ser Thr Asn Ser Val Val Thr Gly
                1125                1130                1135    
Cys Leu Gln Leu Asn Val Cys Asn Ser Asn Pro Cys Leu His Gly Gly
            1140                1145                1150        
Asn Cys Glu Asp Ile Tyr Ser Ser Tyr His Cys Ser Cys Pro Leu Gly
        1155                1160                1165            
Trp Ser Gly Lys His Cys Glu Leu Asn Ile Asp Glu Cys Phe Ser Asn
    1170                1175                1180                
Pro Cys Ile His Gly Asn Cys Ser Asp Arg Val Ala Ala Tyr His Cys
1185                1190                1195                1200
Thr Cys Glu Pro Gly Tyr Thr Gly Val Asn Cys Glu Val Asp Ile Asp
                1205                1210                1215    
Asn Cys Gln Ser His Gln Cys Ala Asn Gly Ala Thr Cys Ile Ser His
            1220                1225                1230        
Thr Asn Gly Tyr Ser Cys Leu Cys Phe Gly Asn Phe Thr Gly Lys Phe
        1235                1240                1245            
Cys Arg Gln Ser Arg Leu Pro Ser Thr Val Cys Gly Asn Glu Lys Thr
    1250                1255                1260                
Asn Leu Thr Cys Tyr Asn Gly Gly Asn Cys Thr Glu Phe Gln Thr Glu
1265                1270                1275                1280
Leu Lys Cys Met Cys Arg Pro Gly Phe Thr Gly Glu Trp Cys Glu Lys
                1285                1290                1295    
Asp Ile Asp Glu Cys Ala Ser Asp Pro Cys Val Asn Gly Gly Leu Cys
            1300                1305                1310        
Gln Asp Leu Leu Asn Lys Phe Gln Cys Leu Cys Asp Val Ala Phe Ala
        1315                1320                1325            
Gly Glu Arg Cys Glu Val Asp Val Ser Ser Leu Ser Phe Tyr Val Ser
    1330                1335                1340                
Leu Leu Phe Trp Gln Asn Leu Phe Gln Leu Leu Ser Tyr Leu Ile Leu
1345                1350                1355                1360
Arg Met Asn Asp Glu Pro Val Val Glu Trp Gly Glu Gln Glu Asp Tyr
                1365                1370                1375    


<210> 772
<211> 328
<212> PRT
<213> Homo sapiens

<400> 772
Met Arg Pro Val Arg Leu Met Lys Val Phe Val Thr Arg Arg Ile Pro
 1               5                  10                  15      
Ala Glu Gly Arg Val Ala Leu Ala Arg Ala Ala Asp Cys Glu Val Glu
            20                  25                  30          
Gln Trp Asp Ser Asp Glu Pro Ile Pro Ala Lys Glu Leu Glu Arg Gly
        35                  40                  45              
Val Ala Gly Ala His Gly Leu Leu Cys Leu Leu Ser Asp His Val Asp
    50                  55                  60                  
Lys Arg Ile Leu Asp Ala Ala Gly Ala Asn Leu Lys Val Ile Ser Thr
65                  70                  75                  80  
Met Ser Val Gly Ile Asp His Leu Ala Leu Asp Glu Ile Lys Lys Arg
                85                  90                  95      
Gly Ile Arg Val Gly Tyr Thr Pro Asp Val Leu Thr Asp Thr Thr Ala
            100                 105                 110         
Glu Leu Ala Val Ser Leu Leu Leu Thr Thr Cys Arg Arg Leu Pro Glu
        115                 120                 125             
Ala Ile Glu Glu Val Lys Asn Gly Gly Trp Thr Ser Trp Lys Pro Leu
    130                 135                 140                 
Trp Leu Cys Gly Tyr Gly Leu Thr Gln Ser Thr Val Gly Ile Ile Gly
145                 150                 155                 160 
Leu Gly Arg Ile Gly Gln Ala Ile Ala Arg Arg Leu Lys Pro Phe Gly
                165                 170                 175     
Val Gln Arg Phe Leu Tyr Thr Gly Arg Gln Pro Arg Pro Glu Glu Ala
            180                 185                 190         
Ala Glu Phe Gln Ala Glu Phe Val Ser Thr Pro Glu Leu Ala Ala Gln
        195                 200                 205             
Ser Asp Phe Ile Val Val Ala Cys Ser Leu Thr Pro Ala Thr Glu Gly
    210                 215                 220                 
Leu Cys Asn Lys Asp Phe Phe Gln Lys Met Lys Glu Thr Ala Val Phe
225                 230                 235                 240 
Ile Asn Ile Ser Arg Gly Asp Val Val Asn Gln Asp Asp Leu Tyr Gln
                245                 250                 255     
Ala Leu Ala Ser Gly Lys Ile Ala Ala Ala Gly Leu Asp Val Thr Ser
            260                 265                 270         
Pro Glu Pro Leu Pro Thr Asn His Pro Leu Leu Thr Leu Lys Asn Cys
        275                 280                 285             
Val Ile Leu Pro His Ile Gly Ser Ala Thr His Arg Thr Arg Asn Thr
    290                 295                 300                 
Met Ser Leu Leu Ala Ala Asn Asn Leu Leu Ala Gly Leu Arg Gly Glu
305                 310                 315                 320 
Pro Met Pro Ser Glu Leu Lys Leu
                325             


<210> 773
<211> 294
<212> PRT
<213> Homo sapiens

<400> 773
Met Glu Tyr Pro Ala Pro Ala Thr Val Gln Ala Ala Asp Gly Gly Ala
 1               5                  10                  15      
Ala Gly Pro Tyr Ser Ser Ser Glu Leu Leu Glu Gly Gln Glu Pro Asp
            20                  25                  30          
Gly Val Arg Phe Asp Arg Glu Arg Ala Arg Arg Leu Trp Glu Ala Val
        35                  40                  45              
Ser Gly Ala Gln Pro Val Gly Arg Glu Glu Val Glu His Met Ile Gln
    50                  55                  60                  
Lys Asn Gln Cys Leu Phe Thr Asn Thr Gln Cys Lys Val Cys Cys Ala
65                  70                  75                  80  
Leu Leu Ile Ser Glu Ser Gln Lys Leu Ala His Tyr Gln Ser Lys Lys
                85                  90                  95      
His Ala Asn Lys Val Lys Arg Tyr Leu Ala Ile His Gly Met Glu Thr
            100                 105                 110         
Leu Lys Gly Glu Thr Lys Lys Leu Asp Ser Asp Gln Lys Ser Ser Arg
        115                 120                 125             
Ser Lys Asp Lys Asn Gln Cys Cys Pro Ile Cys Asn Met Thr Phe Ser
    130                 135                 140                 
Ser Pro Val Val Ala Gln Ser His Tyr Leu Gly Lys Thr His Ala Lys
145                 150                 155                 160 
Asn Leu Lys Leu Lys Gln Gln Ser Thr Lys Val Glu Ala Leu His Gln
                165                 170                 175     
Asn Arg Glu Met Ile Asp Pro Asp Lys Phe Cys Ser Leu Cys His Ala
            180                 185                 190         
Thr Phe Asn Asp Pro Val Met Ala Gln Gln His Tyr Val Gly Lys Lys
        195                 200                 205             
His Arg Lys Gln Glu Thr Lys Leu Lys Leu Met Ala Arg Tyr Gly Arg
    210                 215                 220                 
Leu Ala Asp Pro Ala Val Thr Asp Phe Pro Ala Gly Lys Gly Tyr Pro
225                 230                 235                 240 
Cys Lys Thr Cys Lys Ile Val Leu Asn Ser Ile Glu Gln Tyr Gln Ala
                245                 250                 255     
His Val Ser Gly Phe Lys His Lys Asn Gln Ser Pro Lys Thr Val Ala
            260                 265                 270         
Ser Ser Leu Gly Gln Ile Pro Met Gln Arg Gln Pro Ile Gln Lys Asp
        275                 280                 285             
Ser Thr Thr Leu Glu Asp
    290                 


<210> 774
<211> 739
<212> PRT
<213> Homo sapiens

<400> 774
Met Ala Ser Ile Leu Leu Arg Ser Cys Arg Gly Arg Ala Pro Ala Arg
 1               5                  10                  15      
Leu Pro Pro Pro Pro Arg Tyr Thr Val Pro Arg Gly Ser Pro Gly Asp
            20                  25                  30          
Pro Ala His Leu Ser Cys Ala Ser Thr Leu Gly Leu Arg Asn Cys Leu
        35                  40                  45              
Asn Val Pro Phe Gly Cys Cys Thr Pro Ile His Pro Val Tyr Thr Ser
    50                  55                  60                  
Ser Arg Gly Asp His Leu Gly Cys Trp Ala Leu Arg Pro Glu Cys Leu
65                  70                  75                  80  
Arg Ile Val Ser Arg Ala Pro Trp Thr Ser Thr Ser Val Gly Phe Val
                85                  90                  95      
Ala Val Gly Pro Gln Cys Leu Pro Val Arg Gly Trp His Ser Ser Arg
            100                 105                 110         
Pro Val Arg Asp Asp Ser Val Val Glu Lys Ser Leu Lys Ser Leu Lys
        115                 120                 125             
Asp Lys Asn Lys Lys Leu Glu Glu Gly Gly Pro Val Tyr Ser Pro Pro
    130                 135                 140                 
Ala Glu Val Val Val Lys Lys Ser Leu Gly Gln Arg Val Leu Asp Glu
145                 150                 155                 160 
Leu Lys His Tyr Tyr His Gly Phe Arg Leu Leu Trp Ile Asp Thr Lys
                165                 170                 175     
Ile Ala Ala Arg Met Leu Trp Arg Ile Leu Asn Gly His Ser Leu Thr
            180                 185                 190         
Arg Arg Glu Arg Arg Gln Phe Leu Arg Ile Cys Ala Asp Leu Phe Arg
        195                 200                 205             
Leu Val Pro Phe Leu Val Phe Val Val Val Pro Phe Met Glu Phe Leu
    210                 215                 220                 
Leu Pro Val Ala Val Lys Leu Phe Pro Asn Met Leu Pro Ser Thr Phe
225                 230                 235                 240 
Glu Thr Gln Ser Leu Lys Glu Glu Arg Leu Lys Lys Glu Leu Arg Val
                245                 250                 255     
Lys Leu Glu Leu Ala Lys Phe Leu Gln Asp Thr Ile Glu Glu Met Ala
            260                 265                 270         
Leu Lys Asn Lys Ala Ala Lys Gly Ser Ala Thr Lys Asp Phe Ser Val
        275                 280                 285             
Phe Phe Gln Lys Ile Arg Glu Thr Gly Glu Arg Pro Ser Asn Glu Glu
    290                 295                 300                 
Ile Met Arg Phe Ser Lys Leu Phe Glu Asp Glu Leu Thr Leu Asp Asn
305                 310                 315                 320 
Leu Thr Arg Pro Gln Leu Val Ala Leu Cys Lys Leu Leu Glu Leu Gln
                325                 330                 335     
Ser Ile Gly Thr Asn Asn Phe Leu Arg Phe Gln Leu Thr Met Arg Leu
            340                 345                 350         
Arg Ser Ile Lys Ala Asp Asp Lys Leu Ile Ala Glu Glu Gly Val Asp
        355                 360                 365             
Ser Leu Asn Val Lys Glu Leu Gln Ala Ala Cys Arg Ala Arg Gly Met
    370                 375                 380                 
Arg Ala Leu Gly Val Thr Glu Asp Arg Leu Arg Gly Gln Leu Lys Gln
385                 390                 395                 400 
Trp Leu Asp Leu His Leu His Gln Glu Ile Pro Thr Ser Leu Leu Ile
                405                 410                 415     
Leu Ser Arg Ala Met Tyr Leu Pro Asp Thr Leu Ser Pro Ala Asp Gln
            420                 425                 430         
Leu Lys Ser Thr Leu Gln Thr Leu Pro Glu Ile Val Ala Lys Glu Ala
        435                 440                 445             
Gln Val Lys Val Ala Glu Val Glu Gly Glu Gln Val Asp Asn Lys Ala
    450                 455                 460                 
Lys Leu Glu Ala Thr Leu Gln Glu Glu Ala Ala Ile Gln Gln Glu His
465                 470                 475                 480 
Arg Glu Lys Glu Leu Gln Lys Arg Ser Glu Val Ala Lys Asp Phe Glu
                485                 490                 495     
Pro Glu Arg Val Val Ala Ala Pro Gln Arg Pro Gly Thr Glu Pro Gln
            500                 505                 510         
Pro Glu Met Pro Asp Thr Val Leu Gln Ser Glu Thr Leu Lys Asp Thr
        515                 520                 525             
Ala Pro Val Leu Glu Gly Leu Lys Glu Glu Glu Ile Thr Lys Glu Glu
    530                 535                 540                 
Ile Asp Ile Leu Ser Asp Ala Cys Ser Lys Leu Gln Glu Gln Lys Lys
545                 550                 555                 560 
Ser Leu Thr Lys Glu Lys Glu Glu Leu Glu Leu Leu Lys Glu Asp Val
                565                 570                 575     
Gln Asp Tyr Ser Glu Asp Leu Gln Glu Ile Lys Lys Glu Leu Ser Lys
            580                 585                 590         
Thr Gly Glu Glu Lys Tyr Val Glu Glu Ser Lys Ala Ser Lys Arg Leu
        595                 600                 605             
Thr Lys Arg Val Gln Gln Met Ile Gly Gln Ile Asp Gly Leu Ile Ser
    610                 615                 620                 
Gln Leu Glu Met Asp Gln Gln Ala Gly Lys Leu Ala Pro Ala Asn Gly
625                 630                 635                 640 
Met Pro Thr Gly Glu Asn Val Ile Ser Val Ala Glu Leu Ile Asn Ala
                645                 650                 655     
Met Lys Gln Val Lys His Ile Pro Glu Ser Lys Leu Thr Ser Leu Ala
            660                 665                 670         
Ala Ala Leu Asp Glu Asn Lys Asp Gly Lys Val Asn Ile Asp Asp Leu
        675                 680                 685             
Val Lys Val Ile Glu Leu Val Asp Lys Glu Asp Val His Ile Ser Thr
    690                 695                 700                 
Ser Gln Val Ala Glu Ile Val Ala Thr Leu Glu Lys Glu Glu Lys Val
705                 710                 715                 720 
Glu Glu Lys Glu Lys Ala Lys Glu Lys Ala Glu Lys Glu Val Ala Glu
                725                 730                 735     
Val Lys Ser
            


<210> 775
<211> 739
<212> PRT
<213> Homo sapiens

<400> 775
Met Ala Ser Ile Leu Leu Arg Ser Cys Arg Gly Arg Ala Pro Ala Arg
 1               5                  10                  15      
Leu Pro Pro Pro Pro Arg Tyr Thr Val Pro Arg Gly Ser Pro Gly Asp
            20                  25                  30          
Pro Ala His Leu Ser Cys Ala Ser Thr Leu Gly Leu Arg Asn Cys Leu
        35                  40                  45              
Asn Val Pro Phe Gly Cys Cys Thr Pro Ile His Pro Val Tyr Thr Ser
    50                  55                  60                  
Ser Arg Gly Asp His Leu Gly Cys Trp Ala Leu Arg Pro Glu Cys Leu
65                  70                  75                  80  
Arg Ile Val Ser Arg Ala Pro Trp Thr Ser Thr Ser Val Gly Phe Val
                85                  90                  95      
Ala Val Gly Pro Gln Cys Leu Pro Val Arg Gly Trp His Ser Ser Arg
            100                 105                 110         
Pro Val Arg Asp Asp Ser Val Val Glu Lys Ser Leu Lys Ser Leu Lys
        115                 120                 125             
Asp Lys Asn Lys Lys Leu Glu Glu Gly Gly Pro Val Tyr Ser Pro Pro
    130                 135                 140                 
Ala Glu Val Val Val Lys Lys Ser Leu Gly Gln Arg Val Leu Asp Glu
145                 150                 155                 160 
Leu Lys His Tyr Tyr His Gly Phe Arg Leu Leu Trp Ile Asp Thr Lys
                165                 170                 175     
Ile Ala Ala Arg Met Leu Trp Arg Ile Leu Asn Gly His Ser Leu Thr
            180                 185                 190         
Arg Arg Glu Arg Arg Gln Phe Leu Arg Ile Cys Ala Asp Leu Phe Arg
        195                 200                 205             
Leu Val Pro Phe Leu Val Phe Val Val Val Pro Phe Met Glu Phe Leu
    210                 215                 220                 
Leu Pro Val Ala Val Lys Leu Phe Pro Asn Met Leu Pro Ser Thr Phe
225                 230                 235                 240 
Glu Thr Gln Ser Leu Lys Glu Glu Arg Leu Lys Lys Glu Leu Arg Val
                245                 250                 255     
Lys Leu Glu Leu Ala Lys Phe Leu Gln Asp Thr Ile Glu Glu Met Ala
            260                 265                 270         
Leu Lys Asn Lys Ala Ala Lys Gly Ser Ala Thr Lys Asp Phe Ser Val
        275                 280                 285             
Phe Phe Gln Lys Ile Arg Glu Thr Gly Glu Arg Pro Ser Asn Glu Glu
    290                 295                 300                 
Ile Met Arg Phe Ser Lys Leu Phe Glu Asp Glu Leu Thr Leu Asp Asn
305                 310                 315                 320 
Leu Thr Arg Pro Gln Leu Val Ala Leu Cys Lys Leu Leu Glu Leu Gln
                325                 330                 335     
Ser Ile Gly Thr Asn Asn Phe Leu Arg Phe Gln Leu Thr Met Arg Leu
            340                 345                 350         
Arg Ser Ile Lys Ala Asp Asp Lys Leu Ile Ala Glu Glu Gly Val Asp
        355                 360                 365             
Ser Leu Asn Val Lys Glu Leu Gln Ala Ala Cys Arg Ala Arg Gly Met
    370                 375                 380                 
Arg Ala Leu Gly Val Thr Glu Asp Arg Leu Arg Gly Gln Leu Lys Gln
385                 390                 395                 400 
Trp Leu Asp Leu His Leu His Gln Glu Ile Pro Thr Ser Leu Leu Ile
                405                 410                 415     
Leu Ser Arg Ala Met Tyr Leu Pro Asp Thr Leu Ser Pro Ala Asp Gln
            420                 425                 430         
Leu Lys Ser Thr Leu Gln Thr Leu Pro Glu Ile Val Ala Lys Glu Ala
        435                 440                 445             
Gln Val Lys Val Ala Glu Val Glu Gly Glu Gln Val Asp Asn Lys Ala
    450                 455                 460                 
Lys Leu Glu Ala Thr Leu Gln Glu Glu Ala Ala Ile Gln Gln Glu His
465                 470                 475                 480 
Arg Glu Lys Glu Leu Gln Lys Arg Ser Glu Val Ala Lys Asp Phe Glu
                485                 490                 495     
Pro Glu Arg Val Val Ala Ala Pro Gln Arg Pro Gly Thr Glu Pro Gln
            500                 505                 510         
Pro Glu Met Pro Asp Thr Val Leu Gln Ser Glu Thr Leu Lys Asp Thr
        515                 520                 525             
Ala Pro Val Leu Glu Gly Leu Lys Glu Glu Glu Ile Thr Lys Glu Glu
    530                 535                 540                 
Ile Asp Ile Leu Ser Asp Ala Cys Ser Lys Leu Gln Glu Gln Lys Lys
545                 550                 555                 560 
Ser Leu Thr Lys Glu Lys Glu Glu Leu Glu Leu Leu Lys Glu Asp Val
                565                 570                 575     
Gln Asp Tyr Ser Glu Asp Leu Gln Glu Ile Lys Lys Glu Leu Ser Lys
            580                 585                 590         
Thr Gly Glu Glu Lys Tyr Val Glu Glu Ser Lys Ala Ser Lys Arg Leu
        595                 600                 605             
Thr Lys Arg Val Gln Gln Met Ile Gly Gln Ile Asp Gly Leu Ile Ser
    610                 615                 620                 
Gln Leu Glu Met Asp Gln Gln Ala Gly Lys Leu Ala Pro Ala Asn Gly
625                 630                 635                 640 
Met Pro Thr Gly Glu Asn Val Ile Ser Val Ala Glu Leu Ile Asn Ala
                645                 650                 655     
Met Lys Gln Val Lys His Ile Pro Glu Ser Lys Leu Thr Ser Leu Ala
            660                 665                 670         
Ala Ala Leu Asp Glu Asn Lys Asp Gly Lys Val Asn Ile Asp Asp Leu
        675                 680                 685             
Val Lys Val Ile Glu Leu Val Asp Lys Glu Asp Val His Ile Ser Thr
    690                 695                 700                 
Ser Gln Val Ala Glu Ile Val Ala Thr Leu Glu Lys Glu Glu Lys Val
705                 710                 715                 720 
Glu Glu Lys Glu Lys Ala Lys Glu Lys Ala Glu Lys Glu Val Ala Glu
                725                 730                 735     
Val Lys Ser
            


<210> 776
<211> 1086
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 386
<223> Xaa = Any Amino Acid

<400> 776
Met Ala Asn Leu Leu Lys Thr Val Val Thr Gly Cys Ser Cys Pro Leu
 1               5                  10                  15      
Leu Ser Asn Leu Gly Ser Cys Lys Gly Leu Arg Val Lys Lys Asp Phe
            20                  25                  30          
Leu Arg Thr Phe Tyr Thr His Gln Glu Leu Trp Cys Lys Ala Pro Val
        35                  40                  45              
Lys Pro Gly Ile Pro Tyr Lys Gln Leu Thr Val Gly Val Pro Lys Glu
    50                  55                  60                  
Ile Phe Gln Asn Glu Lys Arg Val Ala Leu Ser Pro Ala Gly Val Gln
65                  70                  75                  80  
Asn Leu Val Lys Gln Gly Phe Asn Val Val Val Glu Ser Gly Ala Gly
                85                  90                  95      
Glu Ala Ser Lys Phe Ser Asp Asp His Tyr Arg Val Ala Gly Ala Gln
            100                 105                 110         
Ile Gln Gly Ala Lys Glu Val Leu Ala Ser Asp Leu Val Val Lys Val
        115                 120                 125             
Arg Ala Pro Met Val Asn Pro Thr Leu Gly Val His Glu Ala Asp Leu
    130                 135                 140                 
Leu Lys Thr Ser Gly Thr Leu Ile Ser Phe Ile Tyr Pro Ala Gln Asn
145                 150                 155                 160 
Pro Glu Leu Leu Asn Lys Leu Ser Gln Arg Lys Thr Thr Val Leu Thr
                165                 170                 175     
Met Asp Gln Val Pro Arg Val Thr Ile Ala Gln Gly Tyr Asp Ala Leu
            180                 185                 190         
Ser Ser Met Ala Asn Ile Ala Gly Tyr Lys Ala Val Val Leu Ala Ala
        195                 200                 205             
Asn His Phe Gly Arg Phe Phe Thr Gly Gln Ile Thr Ala Ala Gly Lys
    210                 215                 220                 
Val Pro Pro Ala Lys Ile Leu Ile Val Gly Gly Gly Val Ala Gly Leu
225                 230                 235                 240 
Ala Ser Ala Gly Ala Ala Lys Ser Met Gly Ala Ile Val Arg Gly Phe
                245                 250                 255     
Asp Thr Arg Ala Ala Ala Leu Glu Gln Phe Lys Ser Leu Gly Ala Glu
            260                 265                 270         
Pro Leu Glu Val Asp Leu Lys Glu Ser Gly Glu Gly Gln Gly Gly Tyr
        275                 280                 285             
Ala Lys Glu Met Ser Lys Glu Phe Ile Glu Ala Glu Met Lys Leu Phe
    290                 295                 300                 
Ala Gln Gln Cys Lys Glu Val Asp Ile Leu Ile Ser Thr Ala Leu Ile
305                 310                 315                 320 
Pro Gly Lys Lys Ala Pro Val Leu Phe Asn Lys Glu Met Ile Glu Ser
                325                 330                 335     
Met Lys Glu Gly Ser Val Val Val Asp Leu Ala Ala Glu Ala Gly Gly
            340                 345                 350         
Asn Phe Glu Thr Thr Lys Pro Gly Glu Leu Tyr Ile His Lys Gly Ile
        355                 360                 365             
Thr His Ile Gly Tyr Thr Asp Leu Pro Ser Arg Met Ala Thr Gln Ala
    370                 375                 380                 
Ser Xaa Leu Tyr Ser Asn Asn Ile Thr Lys Leu Leu Lys Ala Ile Ser
385                 390                 395                 400 
Pro Asp Lys Asp Asn Phe Tyr Phe Asp Val Lys Asp Asp Phe Asp Phe
                405                 410                 415     
Gly Thr Met Gly His Val Ile Arg Gly Thr Val Val Met Lys Asp Gly
            420                 425                 430         
Lys Val Ile Phe Pro Ala Pro Thr Pro Lys Asn Ile Pro Gln Gly Ala
        435                 440                 445             
Pro Val Lys Gln Lys Thr Val Ala Glu Leu Glu Ala Glu Lys Ala Ala
    450                 455                 460                 
Thr Ile Thr Pro Phe Arg Lys Thr Met Ser Thr Ala Ser Ala Tyr Thr
465                 470                 475                 480 
Ala Gly Leu Thr Gly Ile Leu Gly Leu Gly Ile Ala Ala Pro Asn Leu
                485                 490                 495     
Ala Phe Ser Gln Met Val Thr Thr Phe Gly Leu Ala Gly Ile Val Gly
            500                 505                 510         
Tyr His Thr Val Trp Gly Val Thr Pro Ala Leu His Ser Pro Leu Met
        515                 520                 525             
Ser Val Thr Asn Ala Ile Ser Gly Leu Thr Ala Val Gly Gly Leu Ala
    530                 535                 540                 
Leu Met Gly Gly His Leu Tyr Pro Ser Thr Thr Ser Gln Gly Leu Ala
545                 550                 555                 560 
Ala Leu Ala Ala Phe Ile Ser Ser Val Asn Ile Ala Gly Gly Phe Leu
                565                 570                 575     
Val Thr Gln Arg Met Leu Asp Met Phe Lys Arg Pro Thr Asp Pro Pro
            580                 585                 590         
Glu Tyr Asn Tyr Leu Tyr Leu Leu Pro Ala Gly Thr Phe Val Gly Gly
        595                 600                 605             
Tyr Leu Ala Ala Leu Tyr Ser Gly Tyr Asn Ile Glu Gln Ile Met Tyr
    610                 615                 620                 
Leu Gly Ser Gly Leu Cys Cys Val Gly Ala Leu Ala Gly Leu Ser Thr
625                 630                 635                 640 
Gln Gly Thr Ala Arg Leu Gly Asn Ala Leu Gly Met Ile Gly Val Ala
                645                 650                 655     
Gly Gly Leu Ala Ala Thr Leu Gly Val Leu Lys Pro Gly Pro Glu Leu
            660                 665                 670         
Leu Ala Gln Met Ser Gly Ala Met Ala Leu Gly Gly Thr Ile Gly Leu
        675                 680                 685             
Thr Ile Ala Lys Arg Ile Gln Ile Ser Asp Leu Pro Gln Leu Val Ala
    690                 695                 700                 
Ala Phe His Ser Leu Val Gly Leu Ala Ala Val Leu Thr Cys Ile Ala
705                 710                 715                 720 
Glu Tyr Ile Ile Glu Tyr Pro His Phe Ala Thr Asp Ala Ala Ala Asn
                725                 730                 735     
Leu Thr Lys Ile Val Ala Tyr Leu Gly Thr Tyr Ile Gly Gly Val Thr
            740                 745                 750         
Phe Ser Gly Ser Leu Ile Ala Tyr Gly Lys Leu Gln Gly Leu Leu Lys
        755                 760                 765             
Ser Ala Pro Leu Leu Leu Pro Gly Arg His Leu Leu Asn Ala Gly Leu
    770                 775                 780                 
Leu Ala Ala Ser Val Gly Gly Ile Ile Pro Phe Met Val Asp Pro Ser
785                 790                 795                 800 
Phe Thr Thr Gly Ile Thr Cys Leu Gly Ala Val Ser Ala Leu Ser Ala
                805                 810                 815     
Val Met Gly Val Thr Leu Thr Pro Ala Ile Gly Gly Ala Asp Met Pro
            820                 825                 830         
Val Val Ile Thr Val Leu Asn Ser Tyr Ser Gly Trp Ala Leu Cys Ala
        835                 840                 845             
Glu Gly Phe Leu Leu Asn Asn Asn Leu Leu Thr Ile Val Gly Ala Leu
    850                 855                 860                 
Ile Gly Ser Ser Gly Ala Ile Leu Ser Tyr Ile Met Cys Val Ala Met
865                 870                 875                 880 
Asn Arg Ser Leu Ala Asn Val Ile Leu Gly Gly Tyr Gly Thr Thr Ser
                885                 890                 895     
Thr Ala Gly Gly Lys Pro Met Glu Ile Ser Gly Thr His Thr Glu Ile
            900                 905                 910         
Asn Leu Asp Asn Ala Ile Asp Met Ile Arg Glu Ala Asn Ser Ile Ile
        915                 920                 925             
Ile Thr Pro Gly Tyr Gly Leu Cys Ala Ala Lys Ala Gln Tyr Pro Ile
    930                 935                 940                 
Ala Asp Leu Val Lys Met Leu Thr Glu Gln Gly Lys Lys Val Arg Phe
945                 950                 955                 960 
Gly Ile His Pro Val Ala Gly Arg Met Pro Gly Gln Leu Asn Val Leu
                965                 970                 975     
Leu Ala Glu Ala Gly Val Pro Tyr Asp Ile Val Leu Glu Met Asp Glu
            980                 985                 990         
Ile Asn His Asp Phe Pro Asp Thr Asp Leu Val Leu Val Ile Gly Ala
        995                 1000                1005            
Asn Asp Thr Val Asn Ser Ala Ala Gln Glu Asp Pro Asn Ser Ile Ile
    1010                1015                1020                
Ala Gly Met Pro Val Leu Glu Val Trp Lys Ser Lys Gln Val Ile Val
1025                1030                1035                1040
Met Lys Arg Ser Leu Gly Val Gly Tyr Ala Ala Val Asp Asn Pro Ile
                1045                1050                1055    
Phe Tyr Lys Pro Asn Thr Ala Met Leu Leu Gly Asp Ala Lys Lys Thr
            1060                1065                1070        
Cys Asp Ala Leu Gln Ala Lys Val Arg Glu Ser Tyr Gln Lys
        1075                1080                1085    


<210> 777
<211> 1086
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 386
<223> Xaa = Any Amino Acid

<400> 777
Met Ala Asn Leu Leu Lys Thr Val Val Thr Gly Cys Ser Cys Pro Leu
 1               5                  10                  15      
Leu Ser Asn Leu Gly Ser Cys Lys Gly Leu Arg Val Lys Lys Asp Phe
            20                  25                  30          
Leu Arg Thr Phe Tyr Thr His Gln Glu Leu Trp Cys Lys Ala Pro Val
        35                  40                  45              
Lys Pro Gly Ile Pro Tyr Lys Gln Leu Thr Val Gly Val Pro Lys Glu
    50                  55                  60                  
Ile Phe Gln Asn Glu Lys Arg Val Ala Leu Ser Pro Ala Gly Val Gln
65                  70                  75                  80  
Asn Leu Val Lys Gln Gly Phe Asn Val Val Val Glu Ser Gly Ala Gly
                85                  90                  95      
Glu Ala Ser Lys Phe Ser Asp Asp His Tyr Arg Val Ala Gly Ala Gln
            100                 105                 110         
Ile Gln Gly Ala Lys Glu Val Leu Ala Ser Asp Leu Val Val Lys Val
        115                 120                 125             
Arg Ala Pro Met Val Asn Pro Thr Leu Gly Val His Glu Ala Asp Leu
    130                 135                 140                 
Leu Lys Thr Ser Gly Thr Leu Ile Ser Phe Ile Tyr Pro Ala Gln Asn
145                 150                 155                 160 
Pro Glu Leu Leu Asn Lys Leu Ser Gln Arg Lys Thr Thr Val Leu Thr
                165                 170                 175     
Met Asp Gln Val Pro Arg Val Thr Ile Ala Gln Gly Tyr Asp Ala Leu
            180                 185                 190         
Ser Ser Met Ala Asn Ile Ala Gly Tyr Lys Ala Val Val Leu Ala Ala
        195                 200                 205             
Asn His Phe Gly Arg Phe Phe Thr Gly Gln Ile Thr Ala Ala Gly Lys
    210                 215                 220                 
Val Pro Pro Ala Lys Ile Leu Ile Val Gly Gly Gly Val Ala Gly Leu
225                 230                 235                 240 
Ala Ser Ala Gly Ala Ala Lys Ser Met Gly Ala Ile Val Arg Gly Phe
                245                 250                 255     
Asp Thr Arg Ala Ala Ala Leu Glu Gln Phe Lys Ser Leu Gly Ala Glu
            260                 265                 270         
Pro Leu Glu Val Asp Leu Lys Glu Ser Gly Glu Gly Gln Gly Gly Tyr
        275                 280                 285             
Ala Lys Glu Met Ser Lys Glu Phe Ile Glu Ala Glu Met Lys Leu Phe
    290                 295                 300                 
Ala Gln Gln Cys Lys Glu Val Asp Ile Leu Ile Ser Thr Ala Leu Ile
305                 310                 315                 320 
Pro Gly Lys Lys Ala Pro Val Leu Phe Asn Lys Glu Met Ile Glu Ser
                325                 330                 335     
Met Lys Glu Gly Ser Val Val Val Asp Leu Ala Ala Glu Ala Gly Gly
            340                 345                 350         
Asn Phe Glu Thr Thr Lys Pro Gly Glu Leu Tyr Ile His Lys Gly Ile
        355                 360                 365             
Thr His Ile Gly Tyr Thr Asp Leu Pro Ser Arg Met Ala Thr Gln Ala
    370                 375                 380                 
Ser Xaa Leu Tyr Ser Asn Asn Ile Thr Lys Leu Leu Lys Ala Ile Ser
385                 390                 395                 400 
Pro Asp Lys Asp Asn Phe Tyr Phe Asp Val Lys Asp Asp Phe Asp Phe
                405                 410                 415     
Gly Thr Met Gly His Val Ile Arg Gly Thr Val Val Met Lys Asp Gly
            420                 425                 430         
Lys Val Ile Phe Pro Ala Pro Thr Pro Lys Asn Ile Pro Gln Gly Ala
        435                 440                 445             
Pro Val Lys Gln Lys Thr Val Ala Glu Leu Glu Ala Glu Lys Ala Ala
    450                 455                 460                 
Thr Ile Thr Pro Phe Arg Lys Thr Met Ser Thr Ala Ser Ala Tyr Thr
465                 470                 475                 480 
Ala Gly Leu Thr Gly Ile Leu Gly Leu Gly Ile Ala Ala Pro Asn Leu
                485                 490                 495     
Ala Phe Ser Gln Met Val Thr Thr Phe Gly Leu Ala Gly Ile Val Gly
            500                 505                 510         
Tyr His Thr Val Trp Gly Val Thr Pro Ala Leu His Ser Pro Leu Met
        515                 520                 525             
Ser Val Thr Asn Ala Ile Ser Gly Leu Thr Ala Val Gly Gly Leu Ala
    530                 535                 540                 
Leu Met Gly Gly His Leu Tyr Pro Ser Thr Thr Ser Gln Gly Leu Ala
545                 550                 555                 560 
Ala Leu Ala Ala Phe Ile Ser Ser Val Asn Ile Ala Gly Gly Phe Leu
                565                 570                 575     
Val Thr Gln Arg Met Leu Asp Met Phe Lys Arg Pro Thr Asp Pro Pro
            580                 585                 590         
Glu Tyr Asn Tyr Leu Tyr Leu Leu Pro Ala Gly Thr Phe Val Gly Gly
        595                 600                 605             
Tyr Leu Ala Ala Leu Tyr Ser Gly Tyr Asn Ile Glu Gln Ile Met Tyr
    610                 615                 620                 
Leu Gly Ser Gly Leu Cys Cys Val Gly Ala Leu Ala Gly Leu Ser Thr
625                 630                 635                 640 
Gln Gly Thr Ala Arg Leu Gly Asn Ala Leu Gly Met Ile Gly Val Ala
                645                 650                 655     
Gly Gly Leu Ala Ala Thr Leu Gly Val Leu Lys Pro Gly Pro Glu Leu
            660                 665                 670         
Leu Ala Gln Met Ser Gly Ala Met Ala Leu Gly Gly Thr Ile Gly Leu
        675                 680                 685             
Thr Ile Ala Lys Arg Ile Gln Ile Ser Asp Leu Pro Gln Leu Val Ala
    690                 695                 700                 
Ala Phe His Ser Leu Val Gly Leu Ala Ala Val Leu Thr Cys Ile Ala
705                 710                 715                 720 
Glu Tyr Ile Ile Glu Tyr Pro His Phe Ala Thr Asp Ala Ala Ala Asn
                725                 730                 735     
Leu Thr Lys Ile Val Ala Tyr Leu Gly Thr Tyr Ile Gly Gly Val Thr
            740                 745                 750         
Phe Ser Gly Ser Leu Ile Ala Tyr Gly Lys Leu Gln Gly Leu Leu Lys
        755                 760                 765             
Ser Ala Pro Leu Leu Leu Pro Gly Arg His Leu Leu Asn Ala Gly Leu
    770                 775                 780                 
Leu Ala Ala Ser Val Gly Gly Ile Ile Pro Phe Met Val Asp Pro Ser
785                 790                 795                 800 
Phe Thr Thr Gly Ile Thr Cys Leu Gly Ala Val Ser Ala Leu Ser Ala
                805                 810                 815     
Val Met Gly Val Thr Leu Thr Pro Ala Ile Gly Gly Ala Asp Met Pro
            820                 825                 830         
Val Val Ile Thr Val Leu Asn Ser Tyr Ser Gly Trp Ala Leu Cys Ala
        835                 840                 845             
Glu Gly Phe Leu Leu Asn Asn Asn Leu Leu Thr Ile Val Gly Ala Leu
    850                 855                 860                 
Ile Gly Ser Ser Gly Ala Ile Leu Ser Tyr Ile Met Cys Val Ala Met
865                 870                 875                 880 
Asn Arg Ser Leu Ala Asn Val Ile Leu Gly Gly Tyr Gly Thr Thr Ser
                885                 890                 895     
Thr Ala Gly Gly Lys Pro Met Glu Ile Ser Gly Thr His Thr Glu Ile
            900                 905                 910         
Asn Leu Asp Asn Ala Ile Asp Met Ile Arg Glu Ala Asn Ser Ile Ile
        915                 920                 925             
Ile Thr Pro Gly Tyr Gly Leu Cys Ala Ala Lys Ala Gln Tyr Pro Ile
    930                 935                 940                 
Ala Asp Leu Val Lys Met Leu Thr Glu Gln Gly Lys Lys Val Arg Phe
945                 950                 955                 960 
Gly Ile His Pro Val Ala Gly Arg Met Pro Gly Gln Leu Asn Val Leu
                965                 970                 975     
Leu Ala Glu Ala Gly Val Pro Tyr Asp Ile Val Leu Glu Met Asp Glu
            980                 985                 990         
Ile Asn His Asp Phe Pro Asp Thr Asp Leu Val Leu Val Ile Gly Ala
        995                 1000                1005            
Asn Asp Thr Val Asn Ser Ala Ala Gln Glu Asp Pro Asn Ser Ile Ile
    1010                1015                1020                
Ala Gly Met Pro Val Leu Glu Val Trp Lys Ser Lys Gln Val Ile Val
1025                1030                1035                1040
Met Lys Arg Ser Leu Gly Val Gly Tyr Ala Ala Val Asp Asn Pro Ile
                1045                1050                1055    
Phe Tyr Lys Pro Asn Thr Ala Met Leu Leu Gly Asp Ala Lys Lys Thr
            1060                1065                1070        
Cys Asp Ala Leu Gln Ala Lys Val Arg Glu Ser Tyr Gln Lys
        1075                1080                1085    


<210> 778
<211> 410
<212> PRT
<213> Homo sapiens

<400> 778
Met Glu Thr Ser Ser Pro Arg Pro Pro Arg Pro Ser Ser Asn Pro Gly
 1               5                  10                  15      
Leu Ser Leu Asp Ala Arg Leu Gly Val Asp Thr Arg Leu Trp Ala Lys
            20                  25                  30          
Val Leu Phe Thr Ala Leu Tyr Ala Leu Ile Trp Ala Leu Gly Ala Ala
        35                  40                  45              
Gly Asn Ala Leu Ser Val His Val Val Leu Lys Ala Arg Ala Gly Arg
    50                  55                  60                  
Ala Gly Arg Leu Arg His His Val Leu Ser Leu Ala Leu Ala Gly Leu
65                  70                  75                  80  
Leu Leu Leu Leu Val Gly Val Pro Val Glu Leu Tyr Ser Phe Val Trp
                85                  90                  95      
Phe His Tyr Pro Trp Val Phe Gly Asp Leu Gly Cys Arg Gly Tyr Tyr
            100                 105                 110         
Phe Val His Glu Leu Cys Ala Tyr Ala Thr Val Leu Ser Val Ala Gly
        115                 120                 125             
Leu Ser Ala Glu Arg Cys Leu Ala Val Cys Gln Pro Leu Arg Ala Arg
    130                 135                 140                 
Ser Leu Leu Thr Pro Arg Arg Thr Arg Trp Leu Val Ala Leu Ser Trp
145                 150                 155                 160 
Ala Ala Ser Leu Gly Leu Ala Leu Pro Met Ala Val Ile Met Gly Gln
                165                 170                 175     
Lys His Glu Leu Glu Thr Ala Asp Gly Glu Pro Glu Pro Ala Ser Arg
            180                 185                 190         
Val Cys Thr Val Leu Val Ser Arg Thr Ala Leu Gln Val Phe Ile Gln
        195                 200                 205             
Val Asn Val Leu Val Ser Phe Val Leu Pro Leu Ala Leu Thr Ala Phe
    210                 215                 220                 
Leu Asn Gly Val Thr Val Ser His Leu Leu Ala Leu Cys Ser Gln Val
225                 230                 235                 240 
Pro Ser Thr Ser Thr Pro Gly Ser Ser Thr Pro Ser Arg Leu Glu Leu
                245                 250                 255     
Leu Ser Glu Glu Gly Leu Leu Ser Phe Ile Val Trp Lys Lys Thr Phe
            260                 265                 270         
Ile Gln Gly Gly Gln Val Ser Leu Val Arg His Lys Asp Val Arg Arg
        275                 280                 285             
Ile Arg Ser Leu Gln Arg Ser Val Gln Val Leu Arg Ala Ile Val Val
    290                 295                 300                 
Met Tyr Val Ile Cys Trp Leu Pro Tyr His Ala Arg Arg Leu Met Tyr
305                 310                 315                 320 
Cys Tyr Val Pro Asp Asp Ala Trp Thr Asp Pro Leu Tyr Asn Phe Tyr
                325                 330                 335     
His Tyr Phe Tyr Met Val Thr Asn Thr Leu Phe Tyr Val Ser Ser Ala
            340                 345                 350         
Val Thr Pro Leu Leu Tyr Asn Ala Val Ser Ser Ser Phe Arg Lys Leu
        355                 360                 365             
Phe Leu Glu Ala Val Ser Ser Leu Cys Gly Glu His His Pro Met Lys
    370                 375                 380                 
Arg Leu Pro Pro Lys Pro Gln Ser Pro Thr Leu Met Asp Thr Ala Ser
385                 390                 395                 400 
Gly Phe Gly Asp Pro Pro Glu Thr Arg Thr
                405                 410 


<210> 779
<211> 310
<212> PRT
<213> Homo sapiens

<400> 779
Met Arg Pro Leu Gln Ile Val Pro Ser Arg Leu Ile Ser Gln Leu Tyr
 1               5                  10                  15      
Cys Gly Leu Lys Pro Pro Ala Ser Thr Arg Asn Gln Ile Cys Leu Lys
            20                  25                  30          
Met Ala Arg Pro Ser Ser Ser Met Ala Asp Phe Arg Lys Phe Phe Ala
        35                  40                  45              
Lys Ala Lys His Ile Val Ile Ile Ser Gly Ala Gly Val Ser Ala Glu
    50                  55                  60                  
Ser Gly Val Pro Thr Phe Arg Gly Ala Gly Gly Tyr Trp Arg Lys Trp
65                  70                  75                  80  
Gln Ala Gln Asp Leu Ala Thr Pro Leu Ala Phe Ala His Asn Pro Ser
                85                  90                  95      
Arg Val Trp Glu Phe Tyr His Tyr Arg Arg Glu Val Met Gly Ser Lys
            100                 105                 110         
Glu Pro Asn Ala Gly His Arg Ala Ile Ala Glu Cys Glu Thr Arg Leu
        115                 120                 125             
Gly Lys Gln Gly Arg Arg Val Val Val Ile Thr Gln Asn Ile Asp Glu
    130                 135                 140                 
Leu His Arg Lys Ala Gly Thr Lys Asn Leu Leu Glu Ile His Gly Ser
145                 150                 155                 160 
Leu Phe Lys Thr Arg Cys Thr Ser Cys Gly Val Val Ala Glu Asn Tyr
                165                 170                 175     
Lys Ser Pro Ile Cys Pro Ala Leu Ser Gly Lys Gly Ala Pro Glu Pro
            180                 185                 190         
Gly Thr Gln Asp Ala Ser Ile Pro Val Glu Lys Leu Pro Arg Cys Glu
        195                 200                 205             
Glu Ala Gly Cys Gly Gly Leu Leu Arg Pro His Val Val Trp Phe Gly
    210                 215                 220                 
Glu Asn Leu Asp Pro Ala Ile Leu Glu Glu Val Asp Arg Glu Leu Ala
225                 230                 235                 240 
His Cys Asp Leu Cys Leu Val Val Gly Thr Ser Ser Val Val Tyr Pro
                245                 250                 255     
Ala Ala Met Phe Ala Pro Gln Val Ala Ala Arg Gly Val Pro Val Ala
            260                 265                 270         
Glu Phe Asn Thr Glu Thr Thr Pro Ala Thr Asn Arg Phe Arg Phe His
        275                 280                 285             
Phe Gln Gly Pro Cys Gly Thr Thr Leu Pro Glu Ala Leu Ala Cys His
    290                 295                 300                 
Glu Asn Glu Thr Val Ser
305                 310 


<210> 780
<211> 89
<212> PRT
<213> Homo sapiens

<400> 780
Met Ala Ala Gln Ile Pro Glu Ser Asp Gln Ile Lys Gln Phe Lys Glu
 1               5                  10                  15      
Phe Leu Gly Thr Tyr Asn Lys Leu Thr Glu Thr Cys Phe Leu Asp Cys
            20                  25                  30          
Val Lys Asp Phe Thr Thr Arg Glu Val Lys Pro Glu Glu Thr Thr Cys
        35                  40                  45              
Ser Glu His Cys Leu Gln Lys Tyr Leu Lys Met Thr Gln Arg Ile Ser
    50                  55                  60                  
Met Arg Phe Gln Glu Tyr His Ile Gln Gln Asn Glu Ala Leu Ala Ala
65                  70                  75                  80  
Lys Ala Gly Leu Leu Gly Gln Pro Arg
                85                  


<210> 781
<211> 89
<212> PRT
<213> Homo sapiens

<400> 781
Met Ala Ala Gln Ile Pro Glu Ser Asp Gln Ile Lys Gln Phe Lys Glu
 1               5                  10                  15      
Phe Leu Gly Thr Tyr Asn Lys Leu Thr Glu Thr Cys Phe Leu Asp Cys
            20                  25                  30          
Val Lys Asp Phe Thr Thr Arg Glu Val Lys Pro Glu Glu Thr Thr Cys
        35                  40                  45              
Ser Glu His Cys Leu Gln Lys Tyr Leu Lys Met Thr Gln Arg Ile Ser
    50                  55                  60                  
Met Arg Phe Gln Glu Tyr His Ile Gln Gln Asn Glu Ala Leu Ala Ala
65                  70                  75                  80  
Lys Ala Gly Leu Leu Gly Gln Pro Arg
                85                  


<210> 782
<211> 478
<212> PRT
<213> Homo sapiens

<400> 782
Lys Cys Lys Val Val Ile Thr Phe Asn Gln Gly Leu Arg Gly Gly Arg
 1               5                  10                  15      
Val Val Glu Leu Lys Lys Ile Val Asp Glu Ala Val Lys His Cys Pro
            20                  25                  30          
Thr Val Gln His Val Leu Val Ala His Arg Thr Asp Asn Lys Val His
        35                  40                  45              
Met Gly Asp Leu Asp Val Pro Leu Glu Gln Glu Met Ala Lys Glu Asp
    50                  55                  60                  
Pro Val Cys Ala Pro Glu Ser Met Gly Ser Glu Asp Met Leu Phe Met
65                  70                  75                  80  
Leu Tyr Thr Ser Gly Ser Thr Gly Met Pro Lys Gly Ile Val His Thr
                85                  90                  95      
Gln Ala Gly Tyr Leu Leu Tyr Ala Ala Leu Thr His Lys Leu Val Phe
            100                 105                 110         
Asp His Gln Pro Gly Asp Ile Phe Gly Cys Val Ala Asp Ile Gly Trp
        115                 120                 125             
Ile Thr Gly His Ser Tyr Val Val Tyr Gly Pro Leu Cys Asn Gly Ala
    130                 135                 140                 
Thr Ser Val Leu Phe Glu Ser Thr Pro Val Tyr Pro Asn Ala Gly Arg
145                 150                 155                 160 
Tyr Trp Glu Thr Val Glu Arg Leu Lys Ile Asn Gln Phe Tyr Gly Ala
                165                 170                 175     
Pro Thr Ala Val Arg Leu Leu Leu Lys Tyr Gly Asp Ala Trp Val Lys
            180                 185                 190         
Lys Tyr Asp Arg Ser Ser Leu Arg Thr Leu Gly Ser Val Gly Glu Pro
        195                 200                 205             
Ile Asn Cys Glu Ala Trp Glu Trp Leu His Arg Val Val Gly Asp Ser
    210                 215                 220                 
Arg Cys Thr Leu Val Asp Thr Trp Trp Gln Thr Glu Thr Gly Gly Ile
225                 230                 235                 240 
Cys Ile Ala Pro Arg Pro Ser Glu Glu Gly Ala Glu Ile Leu Pro Ala
                245                 250                 255     
Met Ala Met Arg Pro Phe Phe Gly Ile Val Pro Val Leu Met Asp Glu
            260                 265                 270         
Lys Gly Ser Val Val Glu Gly Ser Asn Val Ser Gly Ala Leu Cys Ile
        275                 280                 285             
Ser Gln Ala Trp Pro Gly Met Ala Arg Thr Ile Tyr Gly Asp His Gln
    290                 295                 300                 
Arg Phe Val Asp Ala Tyr Phe Lys Ala Tyr Pro Gly Tyr Tyr Phe Thr
305                 310                 315                 320 
Gly Asp Gly Ala Tyr Arg Thr Glu Gly Gly Tyr Tyr Gln Ile Thr Gly
                325                 330                 335     
Arg Met Asp Asp Val Ile Asn Ile Ser Gly His Arg Leu Gly Thr Ala
            340                 345                 350         
Glu Ile Glu Asp Ala Ile Ala Asp His Pro Ala Val Pro Glu Ser Ala
        355                 360                 365             
Val Ile Gly Tyr Pro His Asp Ile Lys Gly Glu Ala Ala Phe Ala Phe
    370                 375                 380                 
Ile Val Val Lys Asp Ser Ala Gly Asp Ser Asp Val Val Val Gln Glu
385                 390                 395                 400 
Leu Lys Ser Met Val Ala Thr Lys Ile Ala Lys Tyr Ala Val Pro Asp
                405                 410                 415     
Glu Ile Leu Val Val Lys Arg Leu Pro Lys Thr Arg Ser Gly Lys Val
            420                 425                 430         
Met Arg Arg Leu Leu Arg Lys Ile Ile Thr Ser Glu Ala Gln Glu Leu
        435                 440                 445             
Gly Asp Thr Thr Thr Leu Glu Asp Pro Ser Ile Ile Ala Glu Ile Leu
    450                 455                 460                 
Ser Val Tyr Gln Lys Cys Lys Asp Lys Gln Ala Ala Ala Lys
465                 470                 475             


<210> 783
<211> 478
<212> PRT
<213> Homo sapiens

<400> 783
Lys Cys Lys Val Val Ile Thr Phe Asn Gln Gly Leu Arg Gly Gly Arg
 1               5                  10                  15      
Val Val Glu Leu Lys Lys Ile Val Asp Glu Ala Val Lys His Cys Pro
            20                  25                  30          
Thr Val Gln His Val Leu Val Ala His Arg Thr Asp Asn Lys Val His
        35                  40                  45              
Met Gly Asp Leu Asp Val Pro Leu Glu Gln Glu Met Ala Lys Glu Asp
    50                  55                  60                  
Pro Val Cys Ala Pro Glu Ser Met Gly Ser Glu Asp Met Leu Phe Met
65                  70                  75                  80  
Leu Tyr Thr Ser Gly Ser Thr Gly Met Pro Lys Gly Ile Val His Thr
                85                  90                  95      
Gln Ala Gly Tyr Leu Leu Tyr Ala Ala Leu Thr His Lys Leu Val Phe
            100                 105                 110         
Asp His Gln Pro Gly Asp Ile Phe Gly Cys Val Ala Asp Ile Gly Trp
        115                 120                 125             
Ile Thr Gly His Ser Tyr Val Val Tyr Gly Pro Leu Cys Asn Gly Ala
    130                 135                 140                 
Thr Ser Val Leu Phe Glu Ser Thr Pro Val Tyr Pro Asn Ala Gly Arg
145                 150                 155                 160 
Tyr Trp Glu Thr Val Glu Arg Leu Lys Ile Asn Gln Phe Tyr Gly Ala
                165                 170                 175     
Pro Thr Ala Val Arg Leu Leu Leu Lys Tyr Gly Asp Ala Trp Val Lys
            180                 185                 190         
Lys Tyr Asp Arg Ser Ser Leu Arg Thr Leu Gly Ser Val Gly Glu Pro
        195                 200                 205             
Ile Asn Cys Glu Ala Trp Glu Trp Leu His Arg Val Val Gly Asp Ser
    210                 215                 220                 
Arg Cys Thr Leu Val Asp Thr Trp Trp Gln Thr Glu Thr Gly Gly Ile
225                 230                 235                 240 
Cys Ile Ala Pro Arg Pro Ser Glu Glu Gly Ala Glu Ile Leu Pro Ala
                245                 250                 255     
Met Ala Met Arg Pro Phe Phe Gly Ile Val Pro Val Leu Met Asp Glu
            260                 265                 270         
Lys Gly Ser Val Val Glu Gly Ser Asn Val Ser Gly Ala Leu Cys Ile
        275                 280                 285             
Ser Gln Ala Trp Pro Gly Met Ala Arg Thr Ile Tyr Gly Asp His Gln
    290                 295                 300                 
Arg Phe Val Asp Ala Tyr Phe Lys Ala Tyr Pro Gly Tyr Tyr Phe Thr
305                 310                 315                 320 
Gly Asp Gly Ala Tyr Arg Thr Glu Gly Gly Tyr Tyr Gln Ile Thr Gly
                325                 330                 335     
Arg Met Asp Asp Val Ile Asn Ile Ser Gly His Arg Leu Gly Thr Ala
            340                 345                 350         
Glu Ile Glu Asp Ala Ile Ala Asp His Pro Ala Val Pro Glu Ser Ala
        355                 360                 365             
Val Ile Gly Tyr Pro His Asp Ile Lys Gly Glu Ala Ala Phe Ala Phe
    370                 375                 380                 
Ile Val Val Lys Asp Ser Ala Gly Asp Ser Asp Val Val Val Gln Glu
385                 390                 395                 400 
Leu Lys Ser Met Val Ala Thr Lys Ile Ala Lys Tyr Ala Val Pro Asp
                405                 410                 415     
Glu Ile Leu Val Val Lys Arg Leu Pro Lys Thr Arg Ser Gly Lys Val
            420                 425                 430         
Met Arg Arg Leu Leu Arg Lys Ile Ile Thr Ser Glu Ala Gln Glu Leu
        435                 440                 445             
Gly Asp Thr Thr Thr Leu Glu Asp Pro Ser Ile Ile Ala Glu Ile Leu
    450                 455                 460                 
Ser Val Tyr Gln Lys Cys Lys Asp Lys Gln Ala Ala Ala Lys
465                 470                 475             


<210> 784
<211> 383
<212> PRT
<213> Homo sapiens

<400> 784
Trp Phe Phe Lys Gly Ile Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu
 1               5                  10                  15      
Ala Pro Gly Asn Met Leu Gly Ser Phe Met Ile Arg Asp Ser Glu Thr
            20                  25                  30          
Thr Lys Gly Ser Tyr Ser Leu Ser Val Arg Asp Tyr Asp Pro Arg Gln
        35                  40                  45              
Gly Asp Thr Val Lys His Tyr Lys Ile Arg Thr Leu Asp Asn Gly Gly
    50                  55                  60                  
Phe Tyr Ile Ser Pro Arg Ser Thr Phe Ser Thr Leu Gln Glu Leu Val
65                  70                  75                  80  
Asp His Tyr Lys Lys Gly Asn Asp Gly Leu Cys Gln Lys Leu Ser Val
                85                  90                  95      
Pro Cys Met Ser Ser Lys Pro Gln Lys Pro Trp Glu Lys Asp Ala Trp
            100                 105                 110         
Glu Ile Pro Arg Glu Ser Leu Lys Leu Glu Lys Lys Leu Gly Ala Gly
        115                 120                 125             
Gln Phe Gly Glu Val Trp Met Ala Thr Tyr Asn Lys His Thr Lys Val
    130                 135                 140                 
Ala Val Lys Thr Met Lys Pro Gly Ser Met Ser Val Glu Ala Phe Leu
145                 150                 155                 160 
Ala Glu Ala Asn Val Met Lys Thr Leu Gln His Asp Lys Leu Val Lys
                165                 170                 175     
Leu His Ala Val Val Thr Lys Glu Pro Ile Tyr Ile Ile Thr Glu Phe
            180                 185                 190         
Met Ala Lys Gly Ser Leu Leu Asp Phe Leu Lys Ser Asp Glu Gly Ser
        195                 200                 205             
Lys Gln Pro Leu Pro Lys Leu Ile Asp Phe Ser Ala Gln Ile Ala Glu
    210                 215                 220                 
Gly Met Ala Phe Ile Glu Gln Arg Asn Tyr Ile His Arg Asp Leu Arg
225                 230                 235                 240 
Ala Ala Asn Ile Leu Val Ser Ala Ser Leu Val Cys Lys Ile Ala Asp
                245                 250                 255     
Phe Gly Leu Ala Arg Val Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu
            260                 265                 270         
Gly Ala Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Phe
        275                 280                 285             
Gly Ser Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu
    290                 295                 300                 
Met Glu Ile Val Thr Tyr Gly Arg Ile Pro Tyr Pro Gly Met Ser Asn
305                 310                 315                 320 
Pro Glu Val Ile Arg Ala Leu Glu Arg Gly Tyr Arg Met Pro Arg Pro
                325                 330                 335     
Glu Asn Cys Pro Glu Glu Leu Tyr Asn Ile Met Met Arg Cys Trp Lys
            340                 345                 350         
Asn Arg Pro Glu Glu Arg Pro Thr Phe Glu Tyr Ile Gln Ser Val Leu
        355                 360                 365             
Asp Asp Phe Tyr Thr Ala Thr Glu Ser Gln Tyr Gln Gln Gln Pro
    370                 375                 380             


<210> 785
<211> 225
<212> PRT
<213> Homo sapiens

<400> 785
Met Asp Leu Arg Ala Gly Asp Ser Trp Gly Met Leu Ala Cys Leu Cys
 1               5                  10                  15      
Thr Val Leu Trp His Leu Pro Ala Val Pro Ala Leu Asn Arg Thr Gly
            20                  25                  30          
Asp Pro Gly Pro Gly Pro Ser Ile Gln Lys Thr Tyr Asp Leu Thr Arg
        35                  40                  45              
Tyr Leu Glu His Gln Leu Arg Ser Leu Ala Gly Thr Tyr Leu Asn Tyr
    50                  55                  60                  
Leu Gly Pro Pro Phe Asn Glu Pro Asp Phe Asn Pro Pro Arg Leu Gly
65                  70                  75                  80  
Ala Glu Thr Leu Pro Arg Ala Thr Val Asp Leu Glu Val Trp Arg Ser
                85                  90                  95      
Leu Asn Asp Lys Leu Arg Leu Thr Gln Asn Tyr Glu Ala Tyr Ser His
            100                 105                 110         
Leu Leu Cys Tyr Leu Arg Gly Leu Asn Arg Gln Ala Ala Thr Ala Glu
        115                 120                 125             
Leu Arg Arg Ser Leu Ala His Phe Cys Thr Ser Leu Gln Gly Leu Leu
    130                 135                 140                 
Gly Ser Ile Ala Gly Val Met Ala Ala Leu Gly Tyr Pro Leu Pro Gln
145                 150                 155                 160 
Pro Leu Pro Gly Thr Glu Pro Thr Trp Thr Pro Gly Pro Ala His Ser
                165                 170                 175     
Asp Phe Leu Gln Lys Met Asp Asp Phe Trp Leu Leu Lys Glu Leu Gln
            180                 185                 190         
Thr Trp Leu Trp Arg Ser Ala Lys Asp Phe Asn Arg Leu Lys Lys Lys
        195                 200                 205             
Met Gln Pro Pro Ala Ala Ala Val Thr Leu His Leu Gly Ala His Gly
    210                 215                 220                 
Phe
225 


<210> 786
<211> 172
<212> PRT
<213> Homo sapiens

<400> 786
Met Val Gly Pro Ala Pro Arg Arg Arg Leu Arg Pro Leu Ala Ala Leu
 1               5                  10                  15      
Ala Leu Val Leu Ala Leu Ala Pro Gly Leu Pro Thr Ala Arg Ala Gly
            20                  25                  30          
Gln Thr Pro Arg Pro Ala Glu Arg Gly Pro Pro Val Arg Leu Phe Thr
        35                  40                  45              
Glu Glu Glu Leu Ala Arg Tyr Gly Gly Glu Glu Glu Asp Gln Pro Ile
    50                  55                  60                  
Tyr Leu Ala Val Lys Gly Val Val Phe Asp Val Thr Ser Gly Lys Glu
65                  70                  75                  80  
Phe Tyr Gly Arg Gly Ala Pro Tyr Asn Ala Leu Thr Gly Lys Asp Ser
                85                  90                  95      
Thr Arg Gly Val Ala Lys Met Ser Leu Asp Pro Ala Asp Leu Thr His
            100                 105                 110         
Asp Thr Thr Gly Leu Thr Ala Lys Glu Leu Glu Ala Leu Asp Glu Val
        115                 120                 125             
Phe Thr Lys Val Tyr Lys Ala Lys Tyr Pro Ile Val Gly Tyr Thr Ala
    130                 135                 140                 
Arg Arg Ile Leu Asn Glu Asp Gly Ser Pro Asn Leu Asp Phe Lys Pro
145                 150                 155                 160 
Glu Asp Gln Pro His Phe Asp Ile Lys Asp Glu Phe
                165                 170         


<210> 787
<211> 207
<212> PRT
<213> Homo sapiens

<400> 787
Met Asn Val Thr Pro Glu Val Lys Ser Arg Gly Met Lys Phe Ala Glu
 1               5                  10                  15      
Glu Gln Leu Leu Lys His Gly Trp Thr Gln Gly Lys Gly Leu Gly Arg
            20                  25                  30          
Lys Glu Asn Gly Ile Thr Gln Ala Leu Arg Val Thr Leu Lys Gln Asp
        35                  40                  45              
Thr His Gly Val Gly His Asp Pro Ala Lys Glu Phe Thr Asn His Trp
    50                  55                  60                  
Trp Asn Glu Leu Phe Asn Lys Thr Ala Ala Asn Leu Val Val Glu Thr
65                  70                  75                  80  
Gly Gln Asp Gly Val Gln Ile Arg Ser Leu Ser Lys Glu Thr Thr Arg
                85                  90                  95      
Tyr Asn His Pro Lys Pro Asn Leu Leu Tyr Gln Lys Phe Val Lys Met
            100                 105                 110         
Ala Thr Leu Thr Ser Gly Gly Glu Lys Pro Asn Lys Asp Leu Glu Ser
        115                 120                 125             
Cys Ser Asp Asp Asp Asn Gln Gly Ser Lys Ser Pro Lys Ile Leu Thr
    130                 135                 140                 
Asp Glu Met Leu Leu Gln Ala Cys Glu Gly Arg Thr Ala His Lys Ala
145                 150                 155                 160 
Ala Arg Leu Gly Ile Thr Met Lys Ala Lys Leu Ala Arg Leu Glu Ala
                165                 170                 175     
Gln Glu Gln Ala Phe Leu Ala Arg Leu Lys Gly Gln Asp Pro Gly Ala
            180                 185                 190         
Pro Gln Leu Gln Ser Glu Ser Lys Pro Pro Lys Lys Lys Lys Lys
        195                 200                 205         


<210> 788
<211> 206
<212> PRT
<213> Homo sapiens

<400> 788
Met Ala Ala Ala Val Leu Gly Gln Leu Gly Ala Leu Trp Ile His Asn
 1               5                  10                  15      
Leu Arg Ser Arg Gly Lys Leu Ala Leu Gly Val Leu Pro Gln Ser Tyr
            20                  25                  30          
Ile His Thr Ser Ala Ser Leu Asp Ile Ser Arg Lys Trp Glu Lys Lys
        35                  40                  45              
Asn Lys Ile Val Tyr Pro Pro Gln Leu Pro Gly Glu Pro Arg Arg Pro
    50                  55                  60                  
Ala Glu Ile Tyr His Cys Arg Arg Gln Ile Lys Tyr Ser Lys Asp Lys
65                  70                  75                  80  
Met Trp Tyr Leu Ala Lys Leu Ile Arg Gly Met Ser Ile Asp Gln Ala
                85                  90                  95      
Leu Ala Gln Leu Glu Phe Asn Asp Lys Lys Gly Ala Lys Ile Ile Lys
            100                 105                 110         
Glu Val Leu Leu Glu Ala Gln Asp Met Ala Val Arg Asp His Asn Val
        115                 120                 125             
Glu Phe Arg Ser Asn Leu Tyr Ile Ala Glu Ser Thr Ser Gly Arg Gly
    130                 135                 140                 
Gln Cys Leu Lys Arg Ile Arg Tyr His Gly Arg Gly Arg Phe Gly Ile
145                 150                 155                 160 
Met Glu Lys Val Tyr Cys His Tyr Phe Val Lys Leu Val Glu Gly Pro
                165                 170                 175     
Pro Pro Pro Pro Glu Pro Pro Lys Thr Ala Val Ala His Ala Lys Glu
            180                 185                 190         
Tyr Ile Gln Gln Leu Arg Ser Arg Thr Ile Val His Thr Leu
        195                 200                 205     


<210> 789
<211> 343
<212> PRT
<213> Homo sapiens

<400> 789
Met Gly Pro Met Leu Asp Ala Ala Thr Arg Lys Pro Ile Trp Arg His
 1               5                  10                  15      
Glu Ile Leu Asp Ala Asp Gly Ile Cys Ser Pro Gly Glu Lys Val Glu
            20                  25                  30          
Asn Lys Gln Val Leu Val Asn Lys Ser Met Pro Thr Val Thr Gln Ile
        35                  40                  45              
Pro Leu Glu Gly Ser Asn Val Pro Gln Gln Pro Gln Tyr Lys Asp Val
    50                  55                  60                  
Pro Ile Thr Tyr Lys Gly Ala Thr Asp Ser Tyr Ile Glu Lys Val Met
65                  70                  75                  80  
Ile Ser Ser Asn Ala Glu Asp Ala Phe Leu Ile Lys Met Leu Leu Arg
                85                  90                  95      
Gln Thr Arg Arg Pro Glu Ile Gly Asp Lys Phe Ser Ser Arg His Gly
            100                 105                 110         
Gln Lys Gly Val Cys Gly Leu Ile Val Pro Gln Glu Asp Met Pro Phe
        115                 120                 125             
Cys Asp Ser Gly Ile Cys Pro Asp Ile Ile Met Asn Pro His Gly Phe
    130                 135                 140                 
Pro Ser Arg Met Thr Val Gly Lys Leu Ile Glu Leu Leu Ala Gly Lys
145                 150                 155                 160 
Ala Gly Val Leu Asp Gly Arg Phe His Tyr Gly Thr Ala Phe Gly Gly
                165                 170                 175     
Ser Lys Val Lys Asp Val Cys Glu Asp Leu Val Cys His Gly Tyr Asn
            180                 185                 190         
Tyr Leu Gly Lys Asp Tyr Val Thr Ser Gly Ile Thr Gly Glu Pro Leu
        195                 200                 205             
Glu Ala Tyr Ile Tyr Phe Gly Pro Val Tyr Tyr Gln Lys Leu Lys His
    210                 215                 220                 
Met Val Leu Asp Lys Met His Ala Arg Ala Arg Gly Pro Arg Ala Val
225                 230                 235                 240 
Leu Thr Arg Gln Pro Thr Glu Gly Arg Ser Arg Asp Gly Gly Leu Arg
                245                 250                 255     
Leu Gly Glu Met Glu Arg Asp Cys Leu Ile Gly Tyr Gly Ala Ser Met
            260                 265                 270         
Leu Leu Leu Glu Arg Leu Met Ile Ser Ser Asp Ala Phe Glu Val Asp
        275                 280                 285             
Val Cys Gly Gln Cys Gly Leu Leu Gly Tyr Ser Gly Trp Cys His Tyr
    290                 295                 300                 
Cys Lys Ser Ser Cys His Val Ser Ser Leu Arg Ile Pro Tyr Ala Cys
305                 310                 315                 320 
Lys Leu Leu Phe Gln Glu Leu Gln Ser Met Asn Ile Ile Pro Arg Leu
                325                 330                 335     
Lys Leu Ser Lys Tyr Asn Glu
            340             


<210> 790
<211> 294
<212> PRT
<213> Homo sapiens

<400> 790
Met Val Val Leu Phe Tyr Trp Asn Asn His Glu Ser Gln Val Leu Lys
 1               5                  10                  15      
Ser Leu Val Ile Cys Leu Val Ala Met Glu Glu Arg Phe Phe Leu His
            20                  25                  30          
Val Leu Ser Ser Ser Arg Ser Ile Leu Glu Asp Pro Pro Ser Ile Ser
        35                  40                  45              
Glu Gly Cys Gly Gly Arg Val Thr Asp Tyr Arg Ile Thr Val Val Pro
    50                  55                  60                  
Leu Ala Ser Val Ile Val Lys Glu Ser Leu Thr Glu Glu Asp Val Leu
65                  70                  75                  80  
Asn Cys Gln Lys Thr Ile Tyr Asn Leu Val Asp Met Glu Arg Lys Asn
                85                  90                  95      
Asp Pro Leu Pro Ile Ser Thr Val Gly Thr Arg Gly Lys Gly Pro Lys
            100                 105                 110         
Arg Asp Glu Gln Tyr Arg Ile Met Trp Asn Glu Leu Glu Thr Leu Val
        115                 120                 125             
Arg Ala His Ile Asn Asn Ser Glu Lys His Gln Arg Val Leu Glu Cys
    130                 135                 140                 
Leu Met Ala Cys Arg Ser Lys Pro Pro Glu Glu Glu Glu Arg Lys Lys
145                 150                 155                 160 
Arg Gly Arg Lys Arg Glu Asp Lys Glu Asp Lys Ser Glu Lys Ala Val
                165                 170                 175     
Lys Asp Tyr Glu Gln Glu Lys Ser Trp Gln Asp Ser Glu Arg Leu Lys
            180                 185                 190         
Gly Ile Leu Glu Arg Gly Lys Glu Glu Leu Ala Glu Ala Glu Ile Ile
        195                 200                 205             
Lys Asp Ser Pro Asp Ser Pro Glu Pro Pro Asn Lys Lys Pro Leu Val
    210                 215                 220                 
Glu Met Asp Glu Thr Pro Gln Val Glu Lys Ser Lys Gly Pro Val Ser
225                 230                 235                 240 
Leu Leu Ser Leu Trp Ser Asn Arg Ile Asn Thr Ala Asn Ser Arg Lys
                245                 250                 255     
His Gln Glu Phe Ala Gly Arg Leu Asn Ser Val Asn Asn Arg Ala Glu
            260                 265                 270         
Leu Tyr Gln His Leu Lys Glu Glu Asn Gly Met Glu Thr Thr Glu Asn
        275                 280                 285             
Gly Lys Ala Ser Arg Gln
    290                 


<210> 791
<211> 441
<212> PRT
<213> Homo sapiens

<400> 791
Met Ala Ala Ser Met Phe Tyr Gly Arg Leu Val Ala Val Ala Thr Leu
 1               5                  10                  15      
Arg Asn His Arg Pro Arg Thr Ala Gln Gln Gln Gln Arg Asn Leu Ser
            20                  25                  30          
Leu His Glu Tyr Met Ser Met Glu Leu Leu Gln Glu Ala Gly Val Ser
        35                  40                  45              
Val Pro Lys Gly Tyr Val Ala Lys Ser Pro Asp Glu Ala Tyr Ala Ile
    50                  55                  60                  
Ala Lys Lys Leu Gly Ser Lys Asp Val Val Ile Lys Ala Gln Val Leu
65                  70                  75                  80  
Ala Gly Gly Arg Gly Lys Gly Thr Phe Glu Ser Gly Leu Lys Gly Gly
                85                  90                  95      
Val Lys Ile Val Phe Ser Pro Glu Glu Ala Lys Ala Val Ser Ser Gln
            100                 105                 110         
Met Ile Gly Lys Lys Leu Phe Thr Lys Gln Thr Gly Glu Lys Gly Arg
        115                 120                 125             
Ile Cys Asn Gln Val Leu Val Cys Glu Arg Lys Tyr Pro Arg Arg Glu
    130                 135                 140                 
Tyr Tyr Phe Ala Ile Thr Met Glu Arg Ser Phe Gln Gly Pro Val Leu
145                 150                 155                 160 
Ile Gly Ser Ser His Gly Gly Val Asn Ile Glu Asp Val Ala Ala Glu
                165                 170                 175     
Thr Pro Glu Ala Ile Ile Lys Glu Pro Ile Asp Ile Glu Glu Gly Ile
            180                 185                 190         
Lys Lys Glu Gln Ala Leu Gln Leu Ala Gln Lys Met Gly Phe Pro Pro
        195                 200                 205             
Asn Ile Val Glu Ser Ala Ala Glu Asn Met Val Lys Leu Tyr Ser Leu
    210                 215                 220                 
Phe Leu Lys Tyr Asp Ala Thr Met Ile Glu Ile Asn Pro Met Val Glu
225                 230                 235                 240 
Asp Ser Asp Gly Ala Val Leu Cys Met Asp Ala Lys Ile Asn Phe Asp
                245                 250                 255     
Ser Asn Ser Ala Tyr Arg Gln Lys Lys Ile Phe Asp Leu Gln Asp Trp
            260                 265                 270         
Thr Gln Glu Asp Glu Arg Asp Lys Asp Ala Ala Lys Ala Asn Leu Asn
        275                 280                 285             
Tyr Ile Gly Leu Asp Gly Asn Ile Gly Cys Leu Val Ser Gly Ala Gly
    290                 295                 300                 
Leu Ala Met Ala Thr Met Asp Ile Ile Lys Leu His Gly Gly Thr Pro
305                 310                 315                 320 
Ala Asn Phe Leu Asp Val Gly Gly Gly Ala Thr Val His Gln Val Thr
                325                 330                 335     
Glu Ala Phe Lys Leu Ile Thr Ser Asp Lys Lys Val Leu Ala Ile Leu
            340                 345                 350         
Val Asn Ile Phe Gly Gly Ile Met Arg Cys Asp Val Ile Ala Gln Gly
        355                 360                 365             
Ile Val Met Ala Val Lys Asp Leu Glu Ile Lys Ile Pro Val Val Val
    370                 375                 380                 
Arg Leu Gln Gly Thr Arg Val Asp Asp Ala Lys Ala Leu Ile Ala Asp
385                 390                 395                 400 
Ser Gly Leu Lys Ile Leu Ala Cys Asp Asp Leu Asp Glu Ala Ala Arg
                405                 410                 415     
Met Val Val Lys Leu Ser Glu Ile Val Thr Leu Ala Lys Gln Ala His
            420                 425                 430         
Val Asp Val Lys Phe Gln Leu Pro Ile
        435                 440     


<210> 792
<211> 573
<212> PRT
<213> Homo sapiens

<400> 792
Met Ser Val Asp Asp Asp Asp Ile Asn Ser Ser Lys Val Ile Asn Asp
 1               5                  10                  15      
Leu Phe Ser Asp Val Leu Glu Glu Gly Glu Leu Asp Met Glu Lys Ser
            20                  25                  30          
Gln Glu Glu Met Asp Gln Ala Leu Ala Glu Ser Ser Glu Glu Gln Glu
        35                  40                  45              
Asp Ala Leu Asn Ile Ser Ser Met Ser Leu Leu Ala Pro Leu Ala Gln
    50                  55                  60                  
Thr Val Gly Val Val Ser Pro Glu Ser Ser Val Ser Thr Pro Arg Leu
65                  70                  75                  80  
Glu Leu Lys Asp Thr Ser Arg Ser Asp Glu Ser Pro Lys Pro Gly Lys
                85                  90                  95      
Phe Gln Arg Thr Arg Val Pro Arg Ala Glu Ser Gly Asp Ser Leu Gly
            100                 105                 110         
Ser Glu Asp Arg Asp Leu Leu Tyr Ser Ile Asp Ala Tyr Arg Ser Gln
        115                 120                 125             
Arg Phe Lys Glu Thr Glu Arg Pro Ser Ile Lys Gln Val Ile Val Arg
    130                 135                 140                 
Lys Glu Asp Val Thr Ser Lys Leu Asp Glu Lys Asn Asn Ala Phe Pro
145                 150                 155                 160 
Cys Gln Val Asn Ile Lys Gln Lys Met Gln Glu Leu Asn Asn Glu Ile
                165                 170                 175     
Asn Met Gln Gln Thr Val Ile Tyr Gln Ala Ser Gln Ala Leu Asn Cys
            180                 185                 190         
Cys Val Asp Glu Glu His Gly Lys Gly Ser Leu Glu Glu Ala Glu Ala
        195                 200                 205             
Glu Arg Leu Leu Leu Ile Ala Thr Gly Lys Arg Thr Leu Leu Ile Asp
    210                 215                 220                 
Glu Leu Asn Lys Leu Lys Asn Glu Gly Pro Gln Arg Lys Asn Lys Ala
225                 230                 235                 240 
Ser Pro Gln Ser Glu Phe Met Pro Ser Lys Gly Ser Val Thr Leu Ser
                245                 250                 255     
Glu Ile Arg Leu Pro Leu Lys Ala Asp Phe Val Cys Ser Thr Val Gln
            260                 265                 270         
Lys Pro Asp Ala Ala Asn Tyr Tyr Tyr Leu Ile Ile Leu Lys Ala Gly
        275                 280                 285             
Ala Glu Asn Met Val Ala Thr Pro Leu Ala Ser Thr Ser Asn Ser Leu
    290                 295                 300                 
Asn Gly Asp Ala Leu Thr Phe Thr Thr Thr Phe Thr Leu Gln Asp Val
305                 310                 315                 320 
Ser Asn Asp Phe Glu Ile Asn Ile Glu Val Tyr Ser Leu Val Gln Lys
                325                 330                 335     
Lys Asp Pro Ser Gly Leu Asp Lys Lys Lys Lys Thr Ser Lys Ser Lys
            340                 345                 350         
Ala Ile Thr Pro Lys Arg Leu Leu Thr Ser Ile Thr Thr Lys Ser Asn
        355                 360                 365             
Ile His Ser Ser Val Met Ala Ser Pro Gly Gly Leu Ser Ala Val Arg
    370                 375                 380                 
Thr Ser Asn Phe Ala Leu Val Gly Ser Tyr Thr Leu Ser Leu Ser Ser
385                 390                 395                 400 
Val Gly Asn Thr Lys Phe Val Leu Asp Lys Val Pro Phe Leu Ser Ser
                405                 410                 415     
Leu Glu Gly His Ile Tyr Leu Lys Ile Lys Cys Gln Val Asn Ser Ser
            420                 425                 430         
Val Glu Glu Arg Gly Phe Leu Thr Ile Phe Glu Asp Val Ser Gly Phe
        435                 440                 445             
Gly Ala Trp His Arg Arg Trp Cys Val Leu Ser Gly Asn Cys Ile Ser
    450                 455                 460                 
Tyr Trp Thr Tyr Pro Asp Asp Glu Lys Arg Lys Asn Pro Ile Gly Arg
465                 470                 475                 480 
Ile Asn Leu Ala Asn Cys Thr Ser Arg Gln Ile Glu Pro Ala Asn Arg
                485                 490                 495     
Glu Phe Cys Ala Arg Arg Asn Thr Phe Glu Leu Ile Thr Val Arg Pro
            500                 505                 510         
Gln Arg Glu Asp Asp Arg Glu Thr Leu Val Ser Gln Cys Arg Asp Thr
        515                 520                 525             
Leu Cys Val Thr Lys Asn Trp Leu Ser Ala Asp Thr Lys Glu Glu Arg
    530                 535                 540                 
Asp Leu Trp Met Gln Lys Leu Asn Gln Val Leu Val Asp Ile Arg Leu
545                 550                 555                 560 
Trp Gln Pro Asp Ala Cys Tyr Lys Pro Ile Gly Lys Pro
                565                 570             


<210> 793
<211> 2242
<212> PRT
<213> Homo sapiens

<400> 793
Gly Glu Met Ala Leu Phe Glu Cys Leu Val Ala Gly Pro Thr Asp Val
 1               5                  10                  15      
Glu Val Asp Trp Leu Cys Arg Gly Arg Leu Leu Gln Pro Ala Leu Leu
            20                  25                  30          
Lys Cys Lys Met His Phe Asp Gly Arg Lys Cys Lys Leu Leu Leu Thr
        35                  40                  45              
Ser Val His Glu Asp Asp Ser Gly Val Tyr Thr Cys Lys Leu Ser Thr
    50                  55                  60                  
Ala Lys Asp Glu Leu Thr Cys Ser Ala Arg Leu Thr Val Arg Pro Ser
65                  70                  75                  80  
Leu Ala Pro Leu Phe Thr Arg Leu Leu Glu Asp Val Glu Val Leu Glu
                85                  90                  95      
Gly Arg Ala Ala Arg Phe Asp Cys Lys Ile Ser Gly Thr Pro Pro Pro
            100                 105                 110         
Val Val Thr Trp Thr His Phe Gly Cys Pro Met Glu Glu Ser Glu Asn
        115                 120                 125             
Leu Arg Leu Arg Gln Asp Gly Gly Leu His Ser Leu His Ile Ala His
    130                 135                 140                 
Val Gly Ser Glu Asp Glu Gly Leu Tyr Ala Val Ser Ala Val Asn Thr
145                 150                 155                 160 
His Gly Gln Ala His Cys Ser Ala Gln Leu Tyr Val Glu Glu Pro Arg
                165                 170                 175     
Thr Ala Ala Ser Gly Pro Ser Ser Lys Leu Glu Lys Met Pro Ser Ile
            180                 185                 190         
Pro Glu Glu Pro Glu Gln Gly Glu Leu Glu Arg Leu Ser Ile Pro Asp
        195                 200                 205             
Phe Leu Arg Pro Leu Gln Asp Leu Glu Val Gly Leu Ala Lys Glu Ala
    210                 215                 220                 
Met Leu Glu Cys Gln Val Thr Gly Leu Pro Tyr Pro Thr Ile Ser Trp
225                 230                 235                 240 
Phe His Asn Gly His Arg Ile Gln Ser Ser Asp Asp Arg Arg Met Thr
                245                 250                 255     
Gln Tyr Arg Asp Val His Arg Leu Val Phe Pro Ala Val Gly Pro Gln
            260                 265                 270         
His Ala Gly Val Tyr Lys Ser Val Ile Ala Asn Lys Leu Gly Lys Ala
        275                 280                 285             
Ala Cys Tyr Ala His Leu Tyr Val Thr Asp Val Val Pro Gly Pro Pro
    290                 295                 300                 
Asp Gly Ala Pro Gln Val Val Ala Val Thr Gly Arg Met Val Thr Leu
305                 310                 315                 320 
Thr Trp Asn Pro Pro Arg Ser Leu Asp Met Ala Ile Asp Pro Asp Ser
                325                 330                 335     
Leu Thr Tyr Thr Val Gln His Gln Val Leu Gly Ser Asp Gln Trp Thr
            340                 345                 350         
Ala Leu Val Thr Gly Leu Arg Glu Pro Gly Trp Ala Ala Thr Gly Leu
        355                 360                 365             
Arg Lys Gly Val Gln His Ile Phe Arg Val Leu Ser Thr Thr Val Lys
    370                 375                 380                 
Ser Ser Ser Lys Pro Ser Pro Pro Ser Glu Pro Val Gln Leu Leu Glu
385                 390                 395                 400 
His Gly Pro Thr Leu Glu Glu Ala Pro Ala Met Leu Asp Lys Pro Asp
                405                 410                 415     
Ile Val Tyr Val Val Glu Gly Gln Pro Ala Ser Val Thr Val Thr Phe
            420                 425                 430         
Asn His Val Glu Ala Gln Val Val Trp Arg Ser Cys Arg Gly Ala Leu
        435                 440                 445             
Leu Glu Ala Arg Ala Gly Val Tyr Glu Leu Ser Gln Pro Asp Asp Asp
    450                 455                 460                 
Gln Tyr Cys Leu Arg Ile Cys Arg Val Ser Arg Arg Asp Met Gly Ala
465                 470                 475                 480 
Leu Thr Cys Thr Ala Arg Asn Arg His Gly Thr Gln Thr Cys Ser Val
                485                 490                 495     
Thr Leu Glu Leu Ala Glu Ala Pro Arg Phe Glu Ser Ile Met Glu Asp
            500                 505                 510         
Val Glu Val Gly Ala Gly Glu Thr Ala Arg Phe Ala Val Val Val Glu
        515                 520                 525             
Gly Lys Pro Leu Pro Asp Ile Met Trp Tyr Lys Asp Glu Val Leu Leu
    530                 535                 540                 
Thr Glu Ser Ser His Val Ser Phe Val Tyr Glu Glu Asn Glu Cys Ser
545                 550                 555                 560 
Leu Val Val Leu Ser Thr Gly Ala Gln Asp Gly Gly Val Tyr Thr Cys
                565                 570                 575     
Thr Ala Gln Asn Leu Ala Gly Glu Val Ser Cys Lys Ala Glu Leu Ala
            580                 585                 590         
Val His Ser Ala Gln Thr Ala Met Glu Val Glu Gly Val Gly Glu Asp
        595                 600                 605             
Glu Asp His Arg Gly Arg Arg Leu Ser Asp Phe Tyr Asp Ile His Gln
    610                 615                 620                 
Glu Ile Gly Arg Gly Ala Phe Ser Tyr Leu Arg Arg Ile Val Glu Arg
625                 630                 635                 640 
Ser Ser Gly Leu Glu Phe Ala Ala Lys Phe Ile Pro Ser Gln Ala Lys
                645                 650                 655     
Pro Lys Ala Ser Ala Arg Arg Glu Ala Arg Leu Leu Ala Arg Leu Gln
            660                 665                 670         
His Asp Cys Val Leu Tyr Phe His Glu Ala Phe Glu Arg Arg Arg Gly
        675                 680                 685             
Leu Val Ile Val Thr Glu Leu Cys Thr Glu Glu Leu Leu Glu Arg Ile
    690                 695                 700                 
Ala Arg Lys Pro Thr Val Cys Glu Ser Glu Ile Arg Ala Tyr Met Arg
705                 710                 715                 720 
Gln Val Leu Glu Gly Ile His Tyr Leu His Gln Ser His Val Leu His
                725                 730                 735     
Leu Asp Val Lys Pro Glu Asn Leu Leu Val Trp Asp Gly Ala Ala Gly
            740                 745                 750         
Glu Gln Gln Val Arg Ile Cys Asp Phe Gly Asn Ala Gln Glu Leu Thr
        755                 760                 765             
Pro Gly Glu Pro Gln Tyr Cys Gln Tyr Gly Thr Pro Glu Phe Val Ala
    770                 775                 780                 
Pro Glu Ile Val Asn Gln Ser Pro Val Ser Gly Val Thr Asp Ile Trp
785                 790                 795                 800 
Pro Val Gly Val Val Ala Phe Leu Cys Leu Thr Gly Ile Ser Pro Phe
                805                 810                 815     
Val Gly Glu Asn Asp Arg Thr Thr Leu Met Asn Ile Arg Asn Tyr Asn
            820                 825                 830         
Val Ala Phe Glu Glu Thr Thr Phe Leu Ser Leu Ser Arg Glu Ala Arg
        835                 840                 845             
Gly Phe Leu Ile Lys Val Leu Val Gln Asp Arg Leu Arg Pro Thr Ala
    850                 855                 860                 
Glu Glu Thr Leu Glu His Pro Trp Phe Lys Thr Gln Ala Lys Gly Ala
865                 870                 875                 880 
Glu Val Ser Thr Asp His Leu Lys Leu Phe Leu Ser Arg Arg Arg Trp
                885                 890                 895     
Gln Arg Ser Gln Ile Ser Tyr Lys Cys His Leu Val Leu Arg Pro Ile
            900                 905                 910         
Pro Glu Leu Leu Arg Ala Pro Pro Glu Arg Val Trp Val Thr Met Pro
        915                 920                 925             
Arg Arg Pro Pro Pro Ser Gly Gly Leu Ser Ser Ser Ser Asp Ser Glu
    930                 935                 940                 
Glu Glu Glu Leu Glu Glu Leu Pro Ser Val Pro Arg Pro Leu Gln Pro
945                 950                 955                 960 
Glu Phe Ser Gly Ser Arg Val Ser Leu Thr Asp Ile Pro Thr Glu Asp
                965                 970                 975     
Glu Ala Leu Gly Thr Pro Glu Thr Gly Ala Ala Thr Pro Met Asp Trp
            980                 985                 990         
Gln Glu Gln Gly Arg Ala Pro Ser Gln Asp Gln Glu Ala Pro Ser Pro
        995                 1000                1005            
Glu Ala Leu Pro Ser Pro Gly Gln Glu Pro Ala Ala Gly Ala Ser Pro
    1010                1015                1020                
Arg Arg Gly Glu Leu Arg Arg Gly Ser Ser Ala Glu Ser Ala Leu Pro
1025                1030                1035                1040
Arg Ala Gly Pro Arg Glu Leu Gly Arg Gly Leu His Lys Ala Ala Ser
                1045                1050                1055    
Val Glu Leu Pro Gln Arg Arg Ser Pro Gly Pro Gly Ala Thr Arg Leu
            1060                1065                1070        
Ala Arg Gly Gly Leu Gly Glu Gly Glu Tyr Ala Gln Arg Leu Gln Ala
        1075                1080                1085            
Leu Arg Gln Arg Leu Leu Arg Gly Gly Pro Glu Asp Gly Lys Val Ser
    1090                1095                1100                
Gly Leu Arg Gly Pro Leu Leu Glu Ser Leu Gly Gly Arg Ala Arg Asp
1105                1110                1115                1120
Pro Arg Met Ala Arg Ala Ala Ser Ser Glu Ala Ala Pro His His Gln
                1125                1130                1135    
Pro Pro Leu Glu Asn Arg Gly Leu Gln Lys Ser Ser Ser Phe Ser Gln
            1140                1145                1150        
Gly Glu Ala Glu Pro Arg Gly Arg His Arg Arg Ala Gly Ala Pro Leu
        1155                1160                1165            
Glu Ile Pro Val Ala Arg Leu Gly Ala Arg Arg Leu Gln Glu Ser Pro
    1170                1175                1180                
Ser Leu Ser Ala Leu Ser Glu Ala Gln Pro Ser Ser Pro Ala Arg Pro
1185                1190                1195                1200
Ser Ala Pro Lys Pro Ser Thr Pro Lys Ser Ala Glu Pro Ser Ala Thr
                1205                1210                1215    
Thr Pro Ser Asp Ala Pro Gln Pro Pro Ala Pro Gln Pro Ala Gln Asp
            1220                1225                1230        
Lys Ala Pro Glu Pro Arg Pro Glu Pro Val Arg Ala Ser Lys Pro Ala
        1235                1240                1245            
Pro Pro Pro Gln Ala Leu Gln Thr Leu Ala Leu Pro Leu Thr Pro Tyr
    1250                1255                1260                
Ala Gln Ile Ile Gln Ser Leu Gln Leu Ser Gly His Ala Gln Gly Pro
1265                1270                1275                1280
Ser Gln Gly Pro Ala Ala Pro Pro Ser Glu Pro Lys Pro His Ala Ala
                1285                1290                1295    
Val Phe Ala Arg Val Ala Ser Pro Pro Pro Gly Ala Pro Glu Lys Arg
            1300                1305                1310        
Val Pro Ser Ala Gly Gly Pro Pro Val Leu Ala Glu Lys Ala Arg Val
        1315                1320                1325            
Pro Thr Val Pro Pro Arg Pro Gly Ser Ser Leu Ser Ser Ser Ile Glu
    1330                1335                1340                
Asn Leu Glu Ser Glu Ala Val Phe Glu Ala Lys Phe Lys Arg Ser Arg
1345                1350                1355                1360
Glu Ser Pro Leu Ser Leu Gly Leu Arg Leu Leu Ser Arg Ser Arg Ser
                1365                1370                1375    
Glu Glu Arg Gly Pro Phe Arg Gly Ala Glu Glu Glu Asp Gly Ile Tyr
            1380                1385                1390        
Arg Pro Ser Pro Ala Gly Thr Pro Leu Glu Leu Val Arg Arg Pro Glu
        1395                1400                1405            
Arg Ser Arg Ser Val Gln Asp Leu Arg Ala Val Gly Glu Pro Gly Leu
    1410                1415                1420                
Val Arg Arg Leu Ser Leu Ser Leu Ser Gln Arg Leu Arg Arg Thr Pro
1425                1430                1435                1440
Pro Ala Gln Arg His Pro Ala Trp Glu Ala Arg Gly Gly Asp Gly Glu
                1445                1450                1455    
Ser Ser Glu Gly Gly Ser Ser Ala Arg Gly Ser Pro Val Leu Ala Met
            1460                1465                1470        
Arg Arg Arg Leu Ser Phe Thr Leu Glu Arg Leu Ser Ser Arg Leu Gln
        1475                1480                1485            
Arg Ser Gly Ser Ser Glu Asp Ser Gly Gly Ala Ser Gly Arg Ser Thr
    1490                1495                1500                
Pro Leu Phe Gly Arg Leu Arg Arg Ala Thr Ser Glu Gly Glu Ser Leu
1505                1510                1515                1520
Arg Arg Leu Gly Leu Pro His Asn Gln Leu Ala Ala Gln Ala Gly Ala
                1525                1530                1535    
Thr Thr Pro Ser Ala Glu Ser Leu Gly Ser Glu Ala Ser Ala Thr Ser
            1540                1545                1550        
Gly Ser Ser Ala Pro Gly Glu Ser Arg Ser Arg Leu Arg Trp Gly Phe
        1555                1560                1565            
Ser Arg Pro Arg Lys Asp Lys Gly Leu Ser Pro Pro Asn Leu Ser Ala
    1570                1575                1580                
Ser Val Gln Glu Glu Leu Gly His Gln Tyr Val Arg Ser Glu Ser Asp
1585                1590                1595                1600
Phe Pro Pro Val Phe His Ile Lys Leu Lys Asp Gln Val Leu Leu Glu
                1605                1610                1615    
Gly Glu Ala Ala Thr Leu Leu Cys Leu Pro Ala Ala Cys Pro Ala Pro
            1620                1625                1630        
His Ile Ser Trp Met Lys Asp Lys Lys Ser Leu Arg Ser Glu Pro Ser
        1635                1640                1645            
Val Ile Ile Val Ser Cys Lys Asp Gly Arg Gln Leu Leu Ser Ile Pro
    1650                1655                1660                
Arg Ala Gly Lys Arg His Ala Gly Leu Tyr Glu Cys Ser Ala Thr Asn
1665                1670                1675                1680
Val Leu Gly Ser Ile Thr Ser Ser Cys Thr Val Ala Val Ala Arg Val
                1685                1690                1695    
Pro Gly Lys Leu Ala Pro Pro Glu Val Thr Gln Thr Tyr Gln Asp Thr
            1700                1705                1710        
Ala Leu Val Leu Trp Lys Pro Gly Asp Ser Arg Ala Pro Cys Thr Tyr
        1715                1720                1725            
Thr Leu Glu Arg Arg Val Asp Gly Glu Ser Val Trp His Pro Val Ser
    1730                1735                1740                
Ser Gly Ile Pro Asp Cys Tyr Tyr Asn Val Thr His Leu Pro Val Gly
1745                1750                1755                1760
Val Thr Val Arg Phe Arg Val Ala Cys Ala Asn Arg Ala Gly Gln Gly
                1765                1770                1775    
Pro Phe Ser Asn Ser Ser Glu Lys Val Phe Val Arg Gly Thr Gln Asp
            1780                1785                1790        
Ser Ser Ala Val Pro Ser Ala Ala His Gln Glu Ala Pro Val Thr Ser
        1795                1800                1805            
Arg Pro Ala Arg Ala Arg Pro Pro Asp Ser Pro Thr Ser Leu Ala Pro
    1810                1815                1820                
Pro Leu Ala Pro Ala Ala Pro Thr Pro Pro Ser Val Thr Val Ser Pro
1825                1830                1835                1840
Ser Ser Pro Pro Thr Pro Pro Ser Gln Ala Leu Ser Ser Leu Lys Ala
                1845                1850                1855    
Val Gly Pro Pro Pro Gln Thr Pro Pro Arg Arg His Arg Gly Leu Gln
            1860                1865                1870        
Ala Ala Arg Pro Ala Glu Pro Thr Leu Pro Ser Thr His Val Thr Pro
        1875                1880                1885            
Ser Glu Pro Lys Pro Phe Val Leu Asp Thr Gly Thr Pro Ile Pro Ala
    1890                1895                1900                
Ser Thr Pro Gln Gly Val Lys Pro Val Ser Ser Ser Thr Pro Val Tyr
1905                1910                1915                1920
Val Val Thr Ser Phe Val Ser Ala Pro Pro Ala Pro Glu Pro Pro Ala
                1925                1930                1935    
Pro Glu Pro Pro Pro Glu Pro Thr Lys Val Thr Val Gln Ser Leu Ser
            1940                1945                1950        
Pro Ala Lys Glu Val Val Ser Ser Pro Gly Ser Ser Pro Arg Ser Ser
        1955                1960                1965            
Pro Arg Pro Glu Gly Thr Thr Leu Arg Gln Gly Pro Pro Gln Lys Pro
    1970                1975                1980                
Tyr Thr Phe Leu Glu Glu Lys Ala Arg Gly Arg Phe Gly Val Val Arg
1985                1990                1995                2000
Ala Cys Arg Glu Asn Ala Thr Gly Arg Thr Phe Val Ala Lys Ile Val
                2005                2010                2015    
Pro Tyr Ala Ala Glu Gly Lys Pro Arg Val Leu Gln Glu Tyr Glu Val
            2020                2025                2030        
Leu Arg Thr Leu His His Glu Arg Ile Met Ser Leu His Glu Ala Tyr
        2035                2040                2045            
Ile Thr Pro Arg Tyr Leu Val Leu Ile Ala Glu Ser Cys Gly Asn Arg
    2050                2055                2060                
Glu Leu Leu Cys Gly Leu Ser Asp Arg Phe Arg Tyr Ser Glu Asp Asp
2065                2070                2075                2080
Val Ala Thr Tyr Met Val Gln Leu Leu Gln Gly Leu Asp Tyr Leu His
                2085                2090                2095    
Gly His His Val Leu His Leu Asp Ile Lys Pro Asp Asn Leu Leu Leu
            2100                2105                2110        
Ala Pro Asp Asn Ala Leu Lys Ile Val Asp Phe Gly Ser Ala Gln Pro
        2115                2120                2125            
Tyr Asn Pro Gln Ala Leu Arg Pro Leu Gly His Arg Thr Gly Thr Leu
    2130                2135                2140                
Glu Phe Met Ala Pro Glu Met Val Lys Gly Glu Pro Ile Gly Ser Ala
2145                2150                2155                2160
Thr Asp Ile Trp Gly Ala Gly Val Leu Thr Tyr Ile Met Leu Ser Gly
                2165                2170                2175    
Arg Ser Pro Phe Tyr Glu Pro Asp Pro Gln Glu Thr Glu Ala Arg Ile
            2180                2185                2190        
Val Gly Gly Arg Phe Asp Ala Phe Gln Leu Tyr Pro Asn Thr Ser Gln
        2195                2200                2205            
Ser Ala Thr Leu Phe Leu Arg Lys Val Leu Ser Val His Pro Trp Ser
    2210                2215                2220                
Arg Pro Ser Ser Cys Leu Ser Val Cys His Lys Glu Ile Lys Met Ala
2225                2230                2235                2240
Ser Ser
        


<210> 794
<211> 1471
<212> PRT
<213> Homo sapiens

<400> 794
Asn Ser Glu His Thr Ala Val Ile Ser Leu Cys Ser Gly Met Leu Gly
 1               5                  10                  15      
Thr Phe Arg Ser His Asp Gly Asp Tyr Phe Ile Glu Pro Leu Gln Ser
            20                  25                  30          
Met Asp Glu Gln Glu Asp Glu Glu Glu Gln Asn Lys Pro His Ile Ile
        35                  40                  45              
Tyr Arg Arg Ser Ala Pro Gln Arg Glu Pro Ser Thr Gly Arg His Ala
    50                  55                  60                  
Cys Asp Thr Ser Glu His Lys Asn Arg His Ser Lys Asp Lys Lys Lys
65                  70                  75                  80  
Thr Arg Ala Arg Lys Trp Gly Glu Arg Ile Asn Leu Ala Gly Asp Val
                85                  90                  95      
Ala Ala Leu Asn Ser Gly Leu Ala Thr Glu Ala Phe Ser Ala Tyr Gly
            100                 105                 110         
Asn Lys Thr Asp Asn Thr Arg Glu Lys Arg Thr His Arg Arg Thr Lys
        115                 120                 125             
Arg Phe Leu Ser Tyr Pro Arg Phe Val Glu Val Leu Val Val Ala Asp
    130                 135                 140                 
Asn Arg Met Val Ser Tyr His Gly Glu Asn Leu Gln His Tyr Ile Leu
145                 150                 155                 160 
Thr Leu Met Ser Ile Val Ala Ser Ile Tyr Lys Asp Pro Ser Ile Gly
                165                 170                 175     
Asn Leu Ile Asn Ile Val Ile Val Asn Leu Ile Val Ile His Asn Glu
            180                 185                 190         
Gln Asp Gly Pro Ser Ile Ser Phe Asn Ala Gln Thr Thr Leu Lys Asn
        195                 200                 205             
Phe Cys Gln Trp Gln His Ser Lys Asn Ser Pro Gly Gly Ile His His
    210                 215                 220                 
Asp Thr Ala Val Leu Leu Thr Arg Gln Asp Ile Cys Arg Ala His Asp
225                 230                 235                 240 
Lys Cys Asp Thr Leu Gly Leu Ala Glu Leu Gly Thr Ile Cys Asp Pro
                245                 250                 255     
Tyr Arg Ser Cys Ser Ile Ser Glu Asp Ser Gly Leu Ser Thr Ala Phe
            260                 265                 270         
Thr Ile Ala His Glu Leu Gly His Val Phe Asn Met Pro His Asp Asp
        275                 280                 285             
Asn Asn Lys Cys Lys Glu Glu Gly Val Lys Ser Pro Gln His Val Met
    290                 295                 300                 
Ala Pro Thr Leu Asn Phe Tyr Thr Asn Pro Trp Met Trp Ser Lys Cys
305                 310                 315                 320 
Ser Arg Lys Tyr Ile Thr Glu Phe Leu Asp Thr Gly Tyr Gly Glu Cys
                325                 330                 335     
Leu Leu Asn Glu Pro Glu Ser Arg Pro Tyr Pro Leu Pro Val Gln Leu
            340                 345                 350         
Pro Gly Ile Leu Tyr Asn Val Asn Lys Gln Cys Glu Leu Ile Phe Gly
        355                 360                 365             
Pro Gly Ser Gln Val Cys Pro Tyr Met Met Gln Cys Arg Arg Leu Trp
    370                 375                 380                 
Cys Asn Asn Val Asn Gly Val His Lys Gly Cys Arg Thr Gln His Thr
385                 390                 395                 400 
Pro Trp Ala Asp Gly Thr Glu Cys Glu Pro Gly Lys His Cys Lys Tyr
                405                 410                 415     
Gly Phe Cys Val Pro Lys Glu Met Asp Val Pro Val Thr Asp Gly Ser
            420                 425                 430         
Trp Gly Ser Trp Ser Pro Phe Gly Thr Cys Ser Arg Thr Cys Gly Gly
        435                 440                 445             
Gly Ile Lys Thr Ala Ile Arg Glu Cys Asn Arg Pro Glu Pro Lys Asn
    450                 455                 460                 
Gly Gly Lys Tyr Cys Val Gly Arg Arg Met Lys Phe Lys Ser Cys Asn
465                 470                 475                 480 
Thr Glu Pro Cys Leu Lys Gln Lys Arg Asp Phe Arg Asp Glu Gln Cys
                485                 490                 495     
Ala His Phe Asp Gly Lys His Phe Asn Ile Asn Gly Leu Leu Pro Asn
            500                 505                 510         
Val Arg Trp Val Pro Lys Tyr Ser Gly Ile Leu Met Lys Asp Arg Cys
        515                 520                 525             
Lys Leu Phe Cys Arg Val Ala Gly Asn Thr Ala Tyr Tyr Gln Leu Arg
    530                 535                 540                 
Asp Arg Val Ile Asp Gly Thr Pro Cys Gly Gln Asp Thr Asn Asp Ile
545                 550                 555                 560 
Cys Val Gln Gly Leu Cys Arg Gln Ala Gly Cys Asp His Val Leu Asn
                565                 570                 575     
Ser Lys Ala Arg Arg Asp Lys Cys Gly Val Cys Gly Gly Asp Asn Ser
            580                 585                 590         
Ser Cys Lys Thr Val Ala Gly Thr Phe Asn Thr Val His Tyr Gly Tyr
        595                 600                 605             
Asn Thr Val Val Arg Ile Pro Ala Gly Ala Thr Asn Ile Asp Val Arg
    610                 615                 620                 
Gln His Ser Phe Ser Gly Glu Thr Asp Asp Asp Asn Tyr Leu Ala Leu
625                 630                 635                 640 
Ser Ser Ser Lys Gly Glu Phe Leu Leu Asn Gly Asn Phe Val Val Thr
                645                 650                 655     
Met Ala Lys Arg Glu Ile Arg Ile Gly Asn Ala Val Val Glu Tyr Ser
            660                 665                 670         
Gly Ser Glu Thr Ala Val Glu Arg Ile Asn Ser Thr Asp Arg Ile Glu
        675                 680                 685             
Gln Glu Leu Leu Leu Gln Val Leu Ser Val Gly Lys Leu Tyr Asn Pro
    690                 695                 700                 
Asp Val Arg Tyr Ser Phe Asn Ile Pro Ile Glu Asp Lys Pro Gln Gln
705                 710                 715                 720 
Phe Tyr Trp Asn Ser His Gly Pro Trp Gln Ala Cys Ser Lys Pro Cys
                725                 730                 735     
Gln Gly Glu Arg Lys Arg Lys Leu Val Cys Thr Arg Glu Ser Asp Gln
            740                 745                 750         
Leu Thr Val Ser Asp Gln Arg Cys Asp Arg Leu Pro Gln Pro Gly His
        755                 760                 765             
Ile Thr Glu Pro Cys Gly Thr Asp Cys Asp Leu Arg Trp His Val Ala
    770                 775                 780                 
Ser Arg Ser Glu Cys Ser Ala Gln Cys Gly Leu Gly Tyr Arg Thr Leu
785                 790                 795                 800 
Asp Ile Tyr Cys Ala Lys Tyr Ser Arg Leu Asp Gly Lys Thr Glu Lys
                805                 810                 815     
Val Asp Asp Gly Phe Cys Ser Ser His Pro Lys Pro Ser Asn Arg Glu
            820                 825                 830         
Lys Cys Ser Gly Glu Cys Asn Thr Gly Gly Trp Arg Tyr Ser Ala Trp
        835                 840                 845             
Thr Glu Cys Ser Lys Ser Cys Asp Gly Gly Thr Gln Arg Arg Arg Ala
    850                 855                 860                 
Ile Cys Val Asn Thr Arg Asn Asp Val Leu Asp Asp Ser Lys Cys Thr
865                 870                 875                 880 
His Gln Glu Lys Val Thr Ile Gln Arg Cys Ser Glu Phe Pro Cys Pro
                885                 890                 895     
Gln Trp Lys Ser Gly Asp Trp Ser Glu Cys Leu Val Thr Cys Gly Lys
            900                 905                 910         
Gly His Lys His Arg Gln Val Trp Cys Gln Phe Gly Glu Asp Arg Leu
        915                 920                 925             
Asn Asp Arg Met Cys Asp Pro Glu Thr Lys Pro Thr Ser Met Gln Thr
    930                 935                 940                 
Cys Gln Gln Pro Glu Cys Ala Ser Trp Gln Ala Gly Pro Trp Gly Gln
945                 950                 955                 960 
Cys Ser Val Thr Cys Gly Gln Gly Tyr Gln Leu Arg Ala Val Lys Cys
                965                 970                 975     
Ile Ile Gly Thr Tyr Met Ser Val Val Asp Asp Asn Asp Cys Asn Ala
            980                 985                 990         
Ala Thr Arg Pro Thr Asp Thr Gln Asp Cys Glu Leu Pro Ser Cys His
        995                 1000                1005            
Pro Pro Pro Ala Ala Pro Glu Thr Arg Arg Ser Thr Tyr Ser Ala Pro
    1010                1015                1020                
Arg Thr Gln Trp Arg Phe Gly Ser Trp Thr Pro Cys Ser Ala Thr Cys
1025                1030                1035                1040
Gly Lys Gly Thr Arg Met Arg Tyr Val Ser Cys Arg Asp Glu Asn Gly
                1045                1050                1055    
Ser Val Ala Asp Glu Ser Ala Cys Ala Thr Leu Pro Arg Pro Val Ala
            1060                1065                1070        
Lys Glu Glu Cys Ser Val Thr Pro Cys Gly Gln Trp Lys Ala Leu Asp
        1075                1080                1085            
Trp Ser Ser Cys Ser Val Thr Cys Gly Gln Gly Arg Ala Thr Arg Gln
    1090                1095                1100                
Val Met Cys Val Asn Tyr Ser Asp His Val Ile Asp Arg Ser Glu Cys
1105                1110                1115                1120
Asp Gln Asp Tyr Ile Pro Glu Thr Asp Gln Asp Cys Ser Met Ser Pro
                1125                1130                1135    
Cys Pro Gln Arg Thr Pro Asp Ser Gly Leu Ala Gln His Pro Phe Gln
            1140                1145                1150        
Asn Glu Asp Tyr Arg Pro Arg Ser Ala Ser Pro Ser Arg Thr His Val
        1155                1160                1165            
Leu Gly Gly Asn Gln Trp Arg Thr Gly Pro Trp Gly Ala Cys Ser Ser
    1170                1175                1180                
Thr Cys Ala Gly Gly Ser Gln Arg Arg Val Val Val Cys Gln Asp Glu
1185                1190                1195                1200
Asn Gly Tyr Thr Ala Asn Asp Cys Val Glu Arg Ile Lys Pro Asp Glu
                1205                1210                1215    
Gln Arg Ala Cys Glu Ser Gly Pro Cys Pro Gln Trp Ala Tyr Gly Asn
            1220                1225                1230        
Trp Gly Glu Cys Thr Lys Leu Cys Gly Gly Gly Ile Arg Thr Arg Leu
        1235                1240                1245            
Val Val Cys Gln Arg Ser Asn Gly Glu Arg Phe Pro Asp Leu Ser Cys
    1250                1255                1260                
Glu Ile Leu Asp Lys Pro Pro Asp Arg Glu Gln Cys Asn Thr His Ala
1265                1270                1275                1280
Cys Pro His Asp Ala Ala Trp Ser Thr Gly Pro Trp Ser Ser Cys Ser
                1285                1290                1295    
Val Ser Cys Gly Arg Gly His Lys Gln Arg Asn Val Tyr Cys Met Ala
            1300                1305                1310        
Lys Asp Gly Ser His Leu Glu Ser Asp Tyr Cys Lys His Leu Ala Lys
        1315                1320                1325            
Pro His Gly His Arg Lys Cys Arg Gly Gly Arg Cys Pro Lys Trp Lys
    1330                1335                1340                
Ala Gly Ala Trp Ser Gln Cys Ser Val Ser Cys Gly Arg Gly Val Gln
1345                1350                1355                1360
Gln Arg His Val Gly Cys Gln Ile Gly Thr His Lys Ile Ala Arg Glu
                1365                1370                1375    
Thr Glu Cys Asn Pro Tyr Thr Arg Pro Glu Ser Glu Arg Asp Cys Gln
            1380                1385                1390        
Gly Pro Arg Cys Pro Leu Tyr Thr Trp Arg Ala Glu Glu Trp Gln Glu
        1395                1400                1405            
Cys Thr Lys Thr Cys Gly Glu Gly Ser Arg Tyr Arg Lys Val Val Cys
    1410                1415                1420                
Val Asp Asp Asn Lys Asn Glu Val His Gly Ala Arg Cys Asp Val Ser
1425                1430                1435                1440
Lys Arg Pro Val Asp Arg Glu Ser Cys Ser Leu Gln Pro Cys Glu Tyr
                1445                1450                1455    
Val Trp Ile Thr Gly Glu Trp Ser Glu Val Pro Ser Trp Glu Leu
            1460                1465                1470    


<210> 795
<211> 1265
<212> PRT
<213> Homo sapiens

<400> 795
Met Trp Arg Pro Asn Asn Asn Leu Ser Lys Glu Lys Thr Glu Trp His
 1               5                  10                  15      
Val Glu Lys Ser Ser Gly Lys Leu Gln Ala Ala Met Ala Ser Val Ile
            20                  25                  30          
Val Arg Pro Ser Ser Ser Thr Lys Thr Asp Ser Met Pro Ala Met Gln
        35                  40                  45              
Leu Ala Ser Lys Asp Arg Val Ser Glu Arg Ser Ser Ala Gly Ala His
    50                  55                  60                  
Lys Thr Asp Cys Leu Lys Leu Ala Glu Ala Gly Glu Thr Gly Arg Ile
65                  70                  75                  80  
Ile Leu Pro Asn Val Asn Ser Asp Ser Val His Thr Lys Ser Glu Lys
                85                  90                  95      
Asn Phe Gln Ala Val Ser Gln Gly Ser Val Pro Ser Ser Val Met Ser
            100                 105                 110         
Ala Val Asn Thr Met Cys Asn Thr Lys Thr Asp Val Ile Thr Ser Ala
        115                 120                 125             
Ala Asp Thr Thr Ser Val Ser Ser Trp Gly Gly Ser Glu Val Ile Ser
    130                 135                 140                 
Ser Leu Ser Asn Thr Ile Leu Ala Ser Thr Ser Ser Glu Cys Val Ser
145                 150                 155                 160 
Ser Lys Ser Val Ser Gln Pro Val Ala Gln Lys Gln Glu Cys Lys Val
                165                 170                 175     
Ser Thr Thr Ala Pro Val Thr Leu Ala Ser Ser Lys Thr Gly Ser Val
            180                 185                 190         
Val Gln Pro Ser Ser Gly Phe Ser Gly Thr Thr Asp Phe Ile His Leu
        195                 200                 205             
Lys Lys His Lys Ala Ala Leu Ala Ala Ala Gln Tyr Lys Ser Ser Asn
    210                 215                 220                 
Ala Ser Glu Thr Glu Pro Asn Ala Ile Lys Asn Gln Thr Leu Ser Ala
225                 230                 235                 240 
Ser Leu Pro Leu Asp Ser Thr Val Ile Cys Ser Thr Ile Asn Lys Ala
                245                 250                 255     
Asn Ser Val Gly Asn Gly Gln Ala Ser Gln Thr Ser Gln Pro Asn Tyr
            260                 265                 270         
His Thr Lys Leu Lys Lys Ala Trp Leu Thr Arg His Ser Glu Glu Asp
        275                 280                 285             
Lys Asn Thr Asn Lys Met Glu Asn Ser Gly Asn Ser Val Ser Glu Ile
    290                 295                 300                 
Ile Lys Pro Cys Ser Val Asn Leu Ile Ala Ser Thr Ser Ser Asp Ile
305                 310                 315                 320 
Gln Asn Ser Val Asp Ser Lys Ile Ile Val Asp Lys Tyr Val Lys Asp
                325                 330                 335     
Asp Lys Val Asn Arg Arg Lys Ala Lys Arg Thr Tyr Glu Ser Gly Ser
            340                 345                 350         
Glu Ser Gly Asp Ser Asp Glu Ser Glu Ser Lys Ser Glu Gln Arg Thr
        355                 360                 365             
Lys Arg Gln Pro Lys Pro Thr Tyr Lys Lys Lys Gln Asn Asp Leu Gln
    370                 375                 380                 
Lys Arg Lys Gly Glu Ile Glu Glu Asp Leu Lys Pro Asn Gly Val Leu
385                 390                 395                 400 
Ser Arg Ser Ala Lys Glu Arg Ser Lys Leu Lys Leu Gln Ser Asn Ser
                405                 410                 415     
Asn Thr Gly Ile Pro Arg Ser Val Leu Lys Asp Trp Arg Lys Val Lys
            420                 425                 430         
Lys Leu Lys Gln Thr Gly Glu Ser Phe Leu Gln Asp Asp Ser Cys Cys
        435                 440                 445             
Glu Ile Gly Pro Asn Leu Gln Lys Cys Arg Glu Cys Arg Leu Ile Arg
    450                 455                 460                 
Ser Lys Lys Gly Glu Glu Pro Ala His Ser Pro Val Phe Cys Arg Phe
465                 470                 475                 480 
Tyr Tyr Phe Arg Arg Leu Ser Phe Ser Lys Asn Gly Val Val Arg Ile
                485                 490                 495     
Asp Gly Phe Ser Ser Pro Asp Gln Tyr Asp Asp Glu Ala Met Ser Leu
            500                 505                 510         
Trp Thr His Glu Asn Phe Glu Asp Asp Glu Leu Asp Ile Glu Thr Ser
        515                 520                 525             
Lys Tyr Ile Leu Asp Ile Ile Gly Asp Lys Phe Cys Gln Leu Val Thr
    530                 535                 540                 
Ser Glu Lys Thr Ala Leu Ser Trp Val Lys Lys Asp Ala Lys Ile Ala
545                 550                 555                 560 
Trp Lys Arg Ala Val Arg Gly Val Arg Glu Met Cys Asp Ala Cys Glu
                565                 570                 575     
Ala Thr Leu Phe Asn Ile His Trp Val Cys Gln Lys Cys Gly Phe Val
            580                 585                 590         
Val Cys Leu Asp Cys Tyr Lys Ala Lys Glu Arg Lys Ser Ser Arg Asp
        595                 600                 605             
Lys Glu Leu Tyr Ala Trp Met Lys Cys Val Lys Gly Gln Pro His Asp
    610                 615                 620                 
His Lys His Leu Met Pro Thr Gln Ile Ile Pro Gly Ser Val Leu Thr
625                 630                 635                 640 
Asp Leu Leu Asp Ala Met His Thr Leu Arg Glu Lys Tyr Gly Ile Lys
                645                 650                 655     
Ser His Cys His Cys Thr Asn Lys Gln Asn Leu Gln Val Gly Asn Phe
            660                 665                 670         
Pro Thr Met Asn Gly Val Ser Gln Val Leu Gln Asn Val Leu Asn His
        675                 680                 685             
Ser Asn Lys Ile Ser Leu Cys Met Pro Glu Ser Gln Gln Gln Asn Thr
    690                 695                 700                 
Pro Pro Lys Ser Glu Lys Asn Gly Gly Ser Ser Pro Glu Ser Asp Val
705                 710                 715                 720 
Gly Thr Asp Asn Lys Leu Thr Pro Pro Glu Ser Gln Ser Pro Leu His
                725                 730                 735     
Trp Leu Ala Asp Leu Ala Glu Gln Lys Ala Arg Glu Glu Lys Lys Glu
            740                 745                 750         
Asn Lys Glu Leu Thr Leu Glu Asn Gln Ile Lys Glu Glu Arg Glu Gln
        755                 760                 765             
Asp Asn Ser Glu Ser Pro Asn Gly Arg Thr Ser Pro Leu Val Ser Gln
    770                 775                 780                 
Asn Asn Glu Gln Gly Ser Thr Leu Arg Asp Leu Leu Thr Thr Thr Ala
785                 790                 795                 800 
Gly Lys Leu Arg Val Gly Ser Thr Asp Ala Gly Ile Ala Phe Ala Pro
                805                 810                 815     
Val Tyr Ser Met Gly Ala Pro Ser Ser Lys Ser Gly Arg Thr Met Pro
            820                 825                 830         
Asn Ile Leu Asp Asp Ile Ile Ala Ser Val Val Glu Asn Lys Ile Pro
        835                 840                 845             
Pro Ser Lys Thr Ser Lys Ile Asn Val Lys Pro Glu Leu Lys Glu Glu
    850                 855                 860                 
Pro Glu Glu Ser Ile Ile Ser Ala Val Glu Asn Asn Lys Leu Tyr Ser
865                 870                 875                 880 
Asp Ile Pro His Ser Trp Ile Cys Glu Lys His Ile Leu Trp Leu Lys
                885                 890                 895     
Asp Tyr Lys Asn Ser Ser Asn Trp Lys Leu Phe Lys Glu Cys Trp Lys
            900                 905                 910         
Gln Gly Gln Pro Ala Val Val Ser Gly Val His Lys Lys Met Asn Ile
        915                 920                 925             
Ser Leu Trp Lys Ala Glu Ser Ile Ser Leu Asp Phe Gly Asp His Gln
    930                 935                 940                 
Ala Asp Leu Leu Asn Cys Lys Asp Ser Ile Ile Ser Asn Ala Asn Val
945                 950                 955                 960 
Lys Glu Phe Trp Asp Gly Phe Glu Glu Val Ser Lys Arg Gln Lys Asn
                965                 970                 975     
Lys Ser Gly Glu Thr Val Val Leu Lys Leu Lys Asp Trp Pro Ser Gly
            980                 985                 990         
Glu Asp Phe Lys Thr Met Met Pro Ala Arg Tyr Glu Asp Leu Leu Lys
        995                 1000                1005            
Ser Leu Pro Leu Pro Glu Tyr Cys Asn Pro Glu Gly Lys Phe Asn Leu
    1010                1015                1020                
Ala Ser His Leu Pro Gly Phe Phe Val Arg Pro Asp Leu Gly Pro Arg
1025                1030                1035                1040
Leu Cys Ser Ala Tyr Gly Val Val Ala Ala Lys Asp His Asp Ile Gly
                1045                1050                1055    
Thr Thr Asn Leu His Ile Glu Val Ser Asp Val Val Asn Ile Leu Val
            1060                1065                1070        
Tyr Val Gly Ile Ala Lys Gly Asn Gly Ile Leu Ser Lys Ala Gly Ile
        1075                1080                1085            
Leu Lys Lys Phe Glu Glu Glu Asp Leu Asp Asp Ile Leu Arg Lys Arg
    1090                1095                1100                
Leu Lys Asp Ser Ser Glu Ile Pro Gly Ala Leu Trp His Ile Tyr Ala
1105                1110                1115                1120
Gly Lys Asp Val Asp Lys Ile Arg Glu Phe Leu Gln Lys Ile Ser Lys
                1125                1130                1135    
Glu Gln Gly Leu Glu Val Leu Pro Glu His Asp Pro Ile Arg Asp Gln
            1140                1145                1150        
Ser Trp Tyr Val Asn Lys Lys Leu Arg Gln Arg Leu Leu Glu Glu Tyr
        1155                1160                1165            
Gly Val Arg Thr Cys Thr Leu Ile Gln Phe Leu Gly Asp Ala Ile Val
    1170                1175                1180                
Leu Pro Ala Gly Ala Leu His Gln Val Gln Asn Phe His Ser Cys Ile
1185                1190                1195                1200
Gln Val Thr Glu Asp Phe Val Ser Pro Glu His Leu Val Glu Ser Phe
                1205                1210                1215    
His Leu Thr Gln Glu Leu Arg Leu Leu Lys Glu Glu Ile Asn Tyr Asp
            1220                1225                1230        
Asp Lys Leu Gln Val Lys Asn Ile Leu Tyr His Ala Val Lys Glu Met
        1235                1240                1245            
Val Arg Ala Leu Lys Ile His Glu Asp Glu Val Glu Asp Met Glu Glu
    1250                1255                1260                
Asn
1265


<210> 796
<211> 738
<212> PRT
<213> Homo sapiens

<400> 796
Glu Leu Asn Glu Leu Arg Lys Thr Ile Glu Leu Leu Lys Lys Gln Asn
 1               5                  10                  15      
Ala Ala Ala Gln Ala Ala Ile Asn Gly Val Ile Asn Thr Pro Glu Leu
            20                  25                  30          
Asn Cys Lys Gly Asn Gly Thr Ala Gln Ser Ala Asp Leu Arg Ile Arg
        35                  40                  45              
Arg Gln His Ser Ser Asp Ser Val Ser Ser Ile Asn Ser Ala Thr Ser
    50                  55                  60                  
His Ser Ser Val Gly Ser Asn Ile Glu Ser Asp Ser Lys Lys Lys Lys
65                  70                  75                  80  
Arg Lys Asn Trp Leu Arg Ser Ser Phe Lys Gln Ala Phe Gly Lys Lys
                85                  90                  95      
Lys Ser Pro Lys Ser Ala Ser Ser His Ser Asp Ile Glu Glu Met Thr
            100                 105                 110         
Asp Ser Ser Leu Pro Ser Ser Pro Lys Leu Pro His Asn Gly Ser Thr
        115                 120                 125             
Gly Ser Thr Pro Leu Leu Arg Asn Ser His Ser Asn Ser Leu Ile Ser
    130                 135                 140                 
Glu Cys Met Asp Ser Glu Ala Glu Thr Val Met Gln Leu Arg Asn Glu
145                 150                 155                 160 
Leu Arg Asp Lys Glu Met Lys Leu Thr Asp Ile Arg Leu Glu Ala Leu
                165                 170                 175     
Ser Ser Ala His Gln Leu Asp Gln Leu Arg Glu Ala Met Asn Arg Met
            180                 185                 190         
Gln Ser Glu Ile Glu Lys Leu Lys Ala Glu Asn Asp Arg Leu Lys Ser
        195                 200                 205             
Glu Ser Gln Gly Ser Gly Cys Ser Arg Ala Pro Ser Gln Val Ser Ile
    210                 215                 220                 
Ser Ala Ser Pro Arg Gln Ser Met Gly Leu Ser Gln His Ser Leu Asn
225                 230                 235                 240 
Leu Thr Glu Ser Thr Ser Leu Asp Met Leu Leu Asp Asp Thr Gly Glu
                245                 250                 255     
Cys Ser Ala Arg Lys Glu Gly Gly Arg His Val Lys Ile Val Val Ser
            260                 265                 270         
Phe Gln Glu Glu Met Lys Trp Lys Glu Asp Ser Arg Pro His Leu Phe
        275                 280                 285             
Leu Ile Gly Cys Ile Gly Val Ser Gly Lys Thr Lys Trp Asp Val Leu
    290                 295                 300                 
Asp Gly Val Val Arg Arg Leu Phe Lys Glu Tyr Ile Ile His Val Asp
305                 310                 315                 320 
Pro Val Ser Gln Leu Gly Leu Asn Ser Asp Ser Val Leu Gly Tyr Ser
                325                 330                 335     
Ile Gly Glu Ile Lys Arg Ser Asn Thr Ser Glu Thr Pro Glu Leu Leu
            340                 345                 350         
Pro Cys Gly Tyr Leu Val Gly Glu Asn Thr Thr Ile Ser Val Thr Val
        355                 360                 365             
Lys Gly Leu Ala Glu Asn Ser Leu Asp Ser Leu Val Phe Glu Ser Leu
    370                 375                 380                 
Ile Pro Lys Pro Ile Leu Gln Arg Tyr Val Ser Leu Leu Ile Glu His
385                 390                 395                 400 
Arg Arg Ile Ile Leu Ser Gly Pro Ser Gly Thr Gly Lys Thr Tyr Leu
                405                 410                 415     
Ala Asn Arg Leu Ser Glu Tyr Ile Val Leu Arg Glu Gly Arg Glu Leu
            420                 425                 430         
Thr Asp Gly Val Ile Ala Thr Phe Asn Val Asp His Lys Ser Ser Lys
        435                 440                 445             
Glu Leu Arg Gln Tyr Leu Ser Asn Leu Ala Asp Gln Cys Asn Ser Glu
    450                 455                 460                 
Asn Asn Ala Val Asp Met Pro Leu Val Ile Ile Leu Asp Asn Leu His
465                 470                 475                 480 
His Val Ser Ser Leu Gly Glu Ile Phe Asn Gly Leu Leu Asn Cys Lys
                485                 490                 495     
Tyr His Lys Cys Pro Tyr Ile Ile Gly Thr Met Asn Gln Ala Thr Ser
            500                 505                 510         
Ser Thr Pro Asn Leu Gln Leu His His Asn Phe Arg Trp Val Leu Cys
        515                 520                 525             
Ala Asn His Thr Glu Pro Val Lys Gly Phe Leu Gly Arg Phe Leu Arg
    530                 535                 540                 
Arg Lys Leu Met Glu Thr Glu Ile Ser Gly Arg Val Arg Asn Met Glu
545                 550                 555                 560 
Leu Val Lys Ile Ile Asp Trp Ile Pro Lys Val Trp His His Leu Asn
                565                 570                 575     
Arg Phe Leu Glu Ala His Ser Ser Ser Asp Val Thr Ile Gly Pro Arg
            580                 585                 590         
Leu Phe Leu Ser Cys Pro Ile Asp Val Asp Gly Ser Arg Val Trp Phe
        595                 600                 605             
Thr Asp Leu Trp Asn Tyr Ser Ile Ile Pro Tyr Leu Leu Glu Ala Val
    610                 615                 620                 
Arg Glu Gly Leu Gln Leu Tyr Gly Arg Arg Ala Pro Trp Glu Asp Pro
625                 630                 635                 640 
Ala Lys Trp Val Met Asp Thr Tyr Pro Trp Ala Ala Ser Pro Gln Gln
                645                 650                 655     
His Glu Trp Pro Pro Leu Leu Gln Leu Arg Pro Glu Asp Val Gly Phe
            660                 665                 670         
Asp Gly Tyr Ser Met Pro Arg Glu Gly Ser Thr Ser Lys Gln Met Pro
        675                 680                 685             
Pro Ser Asp Ala Glu Gly Asp Pro Leu Met Asn Met Leu Met Arg Leu
    690                 695                 700                 
Gln Glu Ala Ala Asn Tyr Ser Ser Pro Gln Ser Tyr Asp Ser Asp Ser
705                 710                 715                 720 
Asn Ser Asn Ser His His Asp Asp Ile Leu Asp Ser Ser Leu Glu Ser
                725                 730                 735     
Thr Leu
        


<210> 797
<211> 811
<212> PRT
<213> Homo sapiens

<400> 797
Thr Met Ile Pro Val Thr Glu Leu Arg Tyr Phe Ala Asp Thr Gln Pro
 1               5                  10                  15      
Ala Tyr Arg Ile Leu Lys Pro Trp Trp Asp Val Phe Thr Asp Tyr Ile
            20                  25                  30          
Ser Ile Val Met Leu Met Ile Ala Val Phe Gly Gly Thr Leu Gln Val
        35                  40                  45              
Thr Gln Asp Lys Met Ile Cys Leu Pro Cys Lys Trp Val Thr Lys Asp
    50                  55                  60                  
Ser Cys Asn Asp Ser Phe Arg Gly Trp Ala Ala Pro Gly Pro Glu Pro
65                  70                  75                  80  
Thr Tyr Pro Asn Ser Thr Ile Leu Pro Thr Pro Asp Thr Gly Pro Thr
                85                  90                  95      
Gly Ile Lys Tyr Asp Leu Asp Arg His Gln Tyr Asn Tyr Val Asp Ala
            100                 105                 110         
Val Cys Tyr Glu Asn Arg Leu His Trp Phe Ala Lys Tyr Phe Pro Tyr
        115                 120                 125             
Leu Val Leu Leu His Thr Leu Ile Phe Leu Ala Cys Ser Asn Phe Trp
    130                 135                 140                 
Phe Lys Phe Pro Arg Thr Ser Ser Lys Leu Glu His Phe Val Ser Ile
145                 150                 155                 160 
Leu Leu Lys Cys Phe Asp Ser Pro Trp Thr Thr Arg Ala Leu Ser Glu
                165                 170                 175     
Thr Val Val Glu Glu Ser Asp Pro Lys Pro Ala Phe Ser Lys Met Asn
            180                 185                 190         
Gly Ser Met Asp Lys Lys Ser Ser Thr Val Ser Glu Asp Val Glu Ala
        195                 200                 205             
Thr Val Pro Met Leu Gln Arg Thr Lys Ser Arg Ile Glu Gln Gly Ile
    210                 215                 220                 
Val Asp Arg Ser Glu Thr Gly Val Leu Asp Lys Lys Glu Gly Glu Gln
225                 230                 235                 240 
Ala Lys Ala Leu Phe Glu Lys Val Lys Lys Phe Arg Thr His Val Glu
                245                 250                 255     
Glu Gly Asp Ile Val Tyr Arg Leu Tyr Met Arg Gln Thr Ile Ile Lys
            260                 265                 270         
Val Ile Lys Phe Ile Leu Ile Ile Cys Tyr Thr Val Tyr Tyr Val His
        275                 280                 285             
Asn Ile Lys Phe Asp Val Asp Cys Thr Val Asp Ile Glu Ser Leu Thr
    290                 295                 300                 
Gly Tyr Arg Thr Tyr Arg Cys Ala His Pro Leu Ala Thr Leu Phe Lys
305                 310                 315                 320 
Ile Leu Ala Ser Phe Tyr Ile Ser Leu Val Ile Phe Tyr Gly Leu Ile
                325                 330                 335     
Cys Met Tyr Thr Leu Trp Trp Met Leu Arg Arg Ser Leu Lys Lys Tyr
            340                 345                 350         
Ser Phe Glu Ser Ile Arg Glu Glu Ser Ser Tyr Ser Asp Ile Pro Asp
        355                 360                 365             
Val Lys Asn Asp Phe Ala Phe Met Leu His Leu Ile Asp Gln Tyr Asp
    370                 375                 380                 
Pro Leu Tyr Ser Lys Arg Phe Ala Val Phe Leu Ser Glu Val Ser Glu
385                 390                 395                 400 
Asn Lys Leu Arg Gln Leu Asn Leu Asn Asn Glu Trp Thr Leu Asp Lys
                405                 410                 415     
Leu Arg Gln Arg Leu Thr Lys Asn Ala Gln Asp Lys Leu Glu Leu His
            420                 425                 430         
Leu Phe Met Leu Ser Gly Ile Pro Asp Thr Val Phe Asp Leu Val Glu
        435                 440                 445             
Leu Glu Val Leu Lys Leu Glu Leu Ile Pro Asp Val Thr Ile Pro Pro
    450                 455                 460                 
Ser Ile Ala Gln Leu Thr Gly Leu Lys Glu Leu Trp Leu Tyr His Thr
465                 470                 475                 480 
Ala Ala Lys Ile Glu Ala Pro Ala Leu Ala Phe Leu Arg Glu Asn Leu
                485                 490                 495     
Arg Ala Leu His Ile Lys Phe Thr Asp Ile Lys Glu Ile Pro Leu Trp
            500                 505                 510         
Ile Tyr Ser Leu Lys Thr Leu Glu Glu Leu His Leu Thr Gly Asn Leu
        515                 520                 525             
Ser Ala Glu Asn Asn Arg Tyr Ile Val Ile Asp Gly Leu Arg Glu Leu
    530                 535                 540                 
Lys Arg Leu Lys Val Leu Arg Leu Lys Ser Asn Leu Ser Lys Leu Pro
545                 550                 555                 560 
Gln Val Val Thr Asp Val Gly Val His Leu Gln Lys Leu Ser Ile Asn
                565                 570                 575     
Asn Glu Gly Thr Lys Leu Ile Val Leu Asn Ser Leu Lys Lys Met Ala
            580                 585                 590         
Asn Leu Thr Glu Leu Glu Leu Ile Arg Cys Asp Leu Glu Arg Ile Pro
        595                 600                 605             
His Ser Ile Phe Ser Leu His Asn Leu Gln Glu Ile Asp Leu Lys Asp
    610                 615                 620                 
Asn Asn Leu Lys Thr Ile Glu Glu Ile Ile Ser Phe Gln His Leu His
625                 630                 635                 640 
Arg Leu Thr Cys Leu Lys Leu Trp Tyr Asn His Ile Ala Tyr Ile Pro
                645                 650                 655     
Ile Gln Ile Gly Asn Leu Thr Asn Leu Glu Arg Leu Tyr Leu Asn Arg
            660                 665                 670         
Asn Lys Ile Glu Lys Ile Pro Thr Gln Leu Phe Tyr Cys Arg Lys Leu
        675                 680                 685             
Arg Tyr Leu Asp Leu Ser His Asn Asn Leu Thr Phe Leu Pro Ala Asp
    690                 695                 700                 
Ile Gly Leu Leu Gln Asn Leu Gln Asn Leu Ala Ile Thr Ala Asn Arg
705                 710                 715                 720 
Ile Glu Thr Leu Pro Pro Glu Leu Phe Gln Cys Arg Lys Leu Arg Ala
                725                 730                 735     
Leu His Leu Gly Asn Asn Val Leu Gln Ser Leu Pro Ser Arg Val Gly
            740                 745                 750         
Glu Leu Thr Asn Leu Thr Gln Ile Glu Leu Arg Gly Asn Arg Leu Glu
        755                 760                 765             
Cys Leu Pro Val Glu Leu Gly Glu Cys Pro Leu Leu Lys Arg Ser Gly
    770                 775                 780                 
Leu Val Val Glu Glu Asp Leu Phe Asn Thr Leu Pro Pro Glu Val Lys
785                 790                 795                 800 
Glu Arg Leu Trp Arg Ala Asp Lys Glu Gln Ala
                805                 810     


<210> 798
<211> 1258
<212> PRT
<213> Homo sapiens

<400> 798
Glu Leu Ser Phe Pro Leu Leu Ser Leu Asp Phe Gly Ala His Gln Gly
 1               5                  10                  15      
Leu Gly Ser Ala Asp Met Gly Asp Met Lys Thr Pro Asp Phe Asp Asp
            20                  25                  30          
Leu Leu Ala Ala Phe Asp Ile Pro Asp Ile Asp Ala Asn Glu Ala Ile
        35                  40                  45              
His Ser Gly Pro Glu Glu Asn Glu Gly Pro Gly Gly Pro Gly Lys Pro
    50                  55                  60                  
Glu Pro Gly Val Gly Ser Glu Ser Glu Asp Thr Ala Ala Ala Ser Ala
65                  70                  75                  80  
Gly Asp Gly Pro Gly Val Pro Ala Gln Ala Ser Asp His Gly Leu Pro
                85                  90                  95      
Pro Pro Asp Ile Ser Val Val Ser Val Ile Val Lys Asn Thr Val Cys
            100                 105                 110         
Pro Glu Gln Ser Glu Ala Leu Ala Gly Gly Ser Ala Gly Asp Gly Ala
        115                 120                 125             
Gln Ala Ala Gly Val Thr Lys Glu Gly Pro Val Gly Pro His Arg Met
    130                 135                 140                 
Gln Asn Gly Phe Gly Ser Pro Glu Pro Ser Leu Pro Gly Thr Pro His
145                 150                 155                 160 
Ser Pro Ala Pro Pro Ser Gly Gly Thr Trp Lys Glu Lys Gly Met Glu
                165                 170                 175     
Gly Lys Thr Pro Leu Asp Leu Phe Ala His Phe Gly Pro Glu Pro Gly
            180                 185                 190         
Asp His Ser Asp Pro Leu Pro Pro Ser Ala Pro Ser Pro Thr Arg Glu
        195                 200                 205             
Gly Ala Leu Thr Pro Pro Pro Phe Pro Ser Ser Phe Glu Leu Ala Gln
    210                 215                 220                 
Glu Asn Gly Pro Gly Met Gln Pro Pro Val Ser Ser Pro Pro Leu Gly
225                 230                 235                 240 
Ala Leu Lys Gln Glu Ser Cys Ser Pro His His Pro Gln Val Leu Ala
                245                 250                 255     
Gln Gln Gly Ser Gly Ser Ser Pro Lys Ala Thr Asp Ile Pro Ala Ser
            260                 265                 270         
Ala Ser Pro Pro Pro Val Ala Gly Val Pro Phe Phe Lys Gln Ser Pro
        275                 280                 285             
Gly His Gln Ser Pro Leu Ala Ser Pro Lys Val Pro Val Cys Gln Pro
    290                 295                 300                 
Leu Lys Glu Glu Asp Asp Asp Glu Gly Pro Val Asp Lys Ser Ser Pro
305                 310                 315                 320 
Gly Ser Pro Gln Ser Pro Ser Ser Gly Ala Glu Ala Ala Asp Glu Asp
                325                 330                 335     
Ser Asn Asp Ser Pro Ala Ser Ser Ser Ser Arg Pro Leu Lys Val Arg
            340                 345                 350         
Ile Lys Thr Ile Lys Thr Ser Cys Gly Asn Ile Thr Arg Thr Val Thr
        355                 360                 365             
Gln Val Pro Ser Asp Pro Asp Pro Pro Ala Pro Leu Ala Glu Gly Ala
    370                 375                 380                 
Phe Leu Ala Glu Ala Ser Leu Leu Lys Leu Ser Pro Ala Thr Pro Thr
385                 390                 395                 400 
Ser Glu Gly Pro Lys Val Val Ser Val Gln Leu Gly Asp Gly Thr Arg
                405                 410                 415     
Leu Lys Gly Thr Val Leu Pro Val Ala Thr Ile Gln Asn Ala Ser Thr
            420                 425                 430         
Ala Met Leu Met Ala Ala Ser Val Ala Arg Lys Ala Val Val Leu Pro
        435                 440                 445             
Gly Gly Thr Ala Thr Ser Pro Lys Met Ile Ala Lys Asn Val Leu Gly
    450                 455                 460                 
Leu Val Pro Gln Ala Leu Pro Lys Ala Asp Gly Arg Ala Gly Leu Gly
465                 470                 475                 480 
Thr Gly Gly Gln Lys Val Asn Gly Ala Ser Val Val Met Val Gln Pro
                485                 490                 495     
Ser Lys Thr Ala Thr Gly Pro Ser Thr Gly Gly Gly Thr Val Ile Ser
            500                 505                 510         
Arg Thr Gln Ser Ser Leu Val Glu Ala Phe Asn Lys Ile Leu Asn Ser
        515                 520                 525             
Lys Asn Leu Leu Pro Ala Tyr Arg Pro Asn Leu Ser Pro Pro Ala Glu
    530                 535                 540                 
Ala Gly Leu Ala Leu Pro Pro Thr Gly Tyr Arg Cys Leu Glu Cys Gly
545                 550                 555                 560 
Asp Ala Phe Ser Leu Glu Lys Ser Leu Ala Arg His Tyr Asp Arg Arg
                565                 570                 575     
Ser Met Arg Ile Glu Val Thr Cys Asn His Cys Ala Arg Arg Leu Val
            580                 585                 590         
Phe Phe Asn Lys Cys Ser Leu Leu Leu His Ala Arg Glu His Lys Asp
        595                 600                 605             
Lys Gly Leu Val Met Gln Cys Ser His Leu Val Met Arg Pro Val Ala
    610                 615                 620                 
Leu Asp Gln Met Val Gly Gln Pro Asp Ile Thr Pro Leu Leu Pro Val
625                 630                 635                 640 
Ala Val Pro Pro Val Ser Gly Pro Leu Ala Leu Pro Ala Leu Gly Lys
                645                 650                 655     
Gly Glu Gly Ala Ile Thr Ser Ser Ala Ile Thr Thr Val Ala Ala Glu
            660                 665                 670         
Ala Pro Val Leu Pro Leu Ser Thr Glu Pro Pro Ala Ala Pro Ala Thr
        675                 680                 685             
Ser Ala Tyr Thr Cys Phe Arg Cys Leu Glu Cys Lys Glu Gln Cys Arg
    690                 695                 700                 
Asp Lys Ala Gly Met Ala Ala His Phe Gln Gln Leu Gly Pro Pro Ala
705                 710                 715                 720 
Pro Gly Ala Thr Ser Asn Val Cys Pro Thr Cys Pro Met Met Leu Pro
                725                 730                 735     
Asn Arg Cys Ser Phe Ser Ala His Gln Arg Met His Lys Asn Arg Pro
            740                 745                 750         
Pro His Val Cys Pro Glu Cys Gly Gly Asn Phe Leu Gln Ala Asn Phe
        755                 760                 765             
Gln Thr His Leu Arg Glu Ala Cys Leu His Val Ser Arg Arg Val Gly
    770                 775                 780                 
Tyr Arg Cys Pro Ser Cys Ser Val Val Phe Gly Gly Val Asn Ser Ile
785                 790                 795                 800 
Lys Ser His Ile Gln Thr Ser His Cys Glu Val Phe His Lys Cys Pro
                805                 810                 815     
Ile Cys Pro Met Ala Phe Lys Ser Gly Pro Ser Ala His Ala His Leu
            820                 825                 830         
Tyr Ser Gln His Pro Ser Phe Gln Thr Gln Gln Ala Lys Leu Ile Tyr
        835                 840                 845             
Lys Cys Ala Met Cys Asp Thr Val Phe Thr His Lys Pro Leu Leu Ser
    850                 855                 860                 
Ser His Phe Asp Gln His Leu Leu Pro Gln Arg Val Ser Val Phe Lys
865                 870                 875                 880 
Cys Pro Ser Cys Pro Leu Leu Phe Ala Gln Lys Arg Thr Met Leu Glu
                885                 890                 895     
His Leu Lys Asn Thr His Gln Ser Gly Arg Leu Glu Glu Thr Ala Gly
            900                 905                 910         
Lys Gly Ala Gly Gly Ala Leu Leu Thr Pro Lys Thr Glu Pro Glu Glu
        915                 920                 925             
Leu Ala Val Ser Gln Gly Gly Ala Ala Pro Ala Thr Glu Glu Ser Ser
    930                 935                 940                 
Ser Ser Ser Glu Glu Glu Glu Val Pro Ser Ser Pro Glu Pro Pro Arg
945                 950                 955                 960 
Pro Ala Lys Arg Pro Arg Arg Glu Leu Gly Ser Lys Gly Leu Lys Gly
                965                 970                 975     
Gly Gly Gly Gly Pro Gly Gly Trp Thr Cys Gly Leu Cys His Ser Trp
            980                 985                 990         
Phe Pro Glu Arg Asp Glu Tyr Val Ala His Met Lys Lys Glu His Gly
        995                 1000                1005            
Lys Ser Val Lys Lys Phe Pro Cys Arg Leu Cys Glu Arg Ser Phe Cys
    1010                1015                1020                
Ser Ala Pro Ser Leu Arg Arg His Val Arg Val Asn His Glu Gly Ile
1025                1030                1035                1040
Lys Arg Val Tyr Pro Cys Arg Tyr Cys Thr Glu Gly Lys Arg Thr Phe
                1045                1050                1055    
Ser Ser Arg Leu Ile Leu Glu Lys His Val Gln Val Arg His Gly Leu
            1060                1065                1070        
Gln Leu Gly Ala Gln Ser Pro Gly Arg Gly Thr Thr Leu Ala Arg Gly
        1075                1080                1085            
Ser Ser Ala Arg Ala Gln Gly Pro Gly Arg Lys Arg Arg Gln Ser Ser
    1090                1095                1100                
Asp Ser Cys Ser Glu Glu Pro Asp Ser Thr Thr Pro Pro Ala Lys Ser
1105                1110                1115                1120
Pro Arg Gly Gly Pro Gly Ser Gly Gly His Gly Pro Leu Arg Tyr Arg
                1125                1130                1135    
Ser Ser Ser Ser Thr Glu Gln Ser Leu Met Met Gly Leu Arg Val Glu
            1140                1145                1150        
Asp Gly Ala Gln Gln Cys Leu Asp Cys Gly Leu Cys Phe Ala Ser Pro
        1155                1160                1165            
Gly Ser Leu Ser Arg His Arg Phe Ile Ser His Lys Lys Arg Arg Gly
    1170                1175                1180                
Val Gly Lys Ala Ser Ala Leu Gly Leu Gly Asp Gly Glu Glu Glu Ala
1185                1190                1195                1200
Pro Pro Ser Arg Ser Asp Pro Asp Gly Gly Asp Ser Pro Leu Pro Ala
                1205                1210                1215    
Ser Gly Gly Pro Leu Thr Cys Lys Val Cys Gly Lys Ser Cys Asp Ser
            1220                1225                1230        
Pro Leu Asn Leu Lys Thr His Phe Arg Thr His Gly Met Ala Phe Ile
        1235                1240                1245            
Arg Ala Arg Gln Gly Ala Val Gly Asp Asn
    1250                1255            


<210> 799
<211> 917
<212> PRT
<213> Homo sapiens

<400> 799
Met Ile Ala Ala Gln Leu Leu Ala Tyr Tyr Phe Thr Glu Leu Lys Asp
 1               5                  10                  15      
Asp Gln Val Lys Lys Ile Asp Lys Tyr Leu Tyr Ala Met Arg Leu Ser
            20                  25                  30          
Asp Glu Thr Leu Ile Asp Ile Met Thr Arg Phe Arg Lys Glu Met Lys
        35                  40                  45              
Asn Gly Leu Ser Arg Asp Phe Asn Pro Thr Ala Thr Val Lys Met Leu
    50                  55                  60                  
Pro Thr Phe Val Arg Ser Ile Pro Asp Gly Ser Glu Lys Gly Asp Phe
65                  70                  75                  80  
Ile Ala Leu Asp Leu Gly Gly Ser Ser Phe Arg Ile Leu Arg Val Gln
                85                  90                  95      
Val Asn His Glu Lys Asn Gln Asn Val His Met Glu Ser Glu Val Tyr
            100                 105                 110         
Asp Thr Pro Glu Asn Ile Val His Gly Ser Gly Ser Gln Leu Phe Asp
        115                 120                 125             
His Val Ala Glu Cys Leu Gly Asp Phe Met Glu Lys Arg Lys Ile Lys
    130                 135                 140                 
Asp Lys Lys Leu Pro Val Gly Phe Thr Phe Ser Phe Pro Cys Gln Gln
145                 150                 155                 160 
Ser Lys Ile Asp Glu Ala Ile Leu Ile Thr Trp Thr Lys Arg Phe Lys
                165                 170                 175     
Ala Ser Gly Val Glu Gly Ala Asp Val Val Lys Leu Leu Asn Lys Ala
            180                 185                 190         
Ile Lys Lys Arg Gly Asp Tyr Asp Ala Asn Ile Val Ala Val Val Asn
        195                 200                 205             
Asp Thr Val Gly Thr Met Met Thr Cys Gly Tyr Asp Asp Gln His Cys
    210                 215                 220                 
Glu Val Gly Leu Ile Ile Gly Thr Gly Thr Asn Ala Cys Tyr Met Glu
225                 230                 235                 240 
Glu Leu Arg His Ile Asp Leu Val Glu Gly Asp Glu Gly Arg Met Cys
                245                 250                 255     
Ile Asn Thr Glu Trp Gly Ala Phe Gly Asp Asp Gly Ser Leu Glu Asp
            260                 265                 270         
Ile Arg Thr Glu Phe Asp Arg Ala Ile Asp Ala Tyr Ser Leu Asn Pro
        275                 280                 285             
Gly Lys Gln Leu Phe Glu Lys Met Val Ser Gly Met Tyr Leu Gly Glu
    290                 295                 300                 
Leu Val Arg Leu Ile Leu Val Lys Met Ala Lys Glu Gly Leu Leu Phe
305                 310                 315                 320 
Glu Gly Arg Ile Thr Pro Glu Leu Leu Thr Arg Gly Lys Phe Asn Thr
                325                 330                 335     
Ser Asp Val Ser Ala Ile Glu Lys Asn Lys Glu Gly Leu His Asn Ala
            340                 345                 350         
Lys Glu Ile Leu Thr Arg Leu Gly Val Glu Pro Ser Asp Asp Asp Cys
        355                 360                 365             
Val Ser Val Gln His Val Cys Thr Ile Val Ser Phe Arg Ser Ala Asn
    370                 375                 380                 
Leu Val Ala Ala Thr Leu Gly Ala Ile Leu Asn Arg Leu Arg Asp Asn
385                 390                 395                 400 
Lys Gly Thr Pro Arg Leu Arg Thr Thr Val Gly Val Asp Gly Ser Leu
                405                 410                 415     
Tyr Lys Thr His Pro Gln Tyr Ser Arg Arg Phe His Lys Thr Leu Arg
            420                 425                 430         
Arg Leu Val Pro Asp Ser Asp Val Arg Phe Leu Leu Ser Glu Ser Gly
        435                 440                 445             
Ser Gly Lys Gly Ala Ala Met Val Thr Ala Val Ala Tyr Arg Leu Ala
    450                 455                 460                 
Glu Gln His Arg Gln Ile Glu Glu Thr Leu Ala His Phe His Leu Thr
465                 470                 475                 480 
Lys Asp Met Leu Leu Glu Val Lys Lys Arg Met Arg Ala Glu Met Glu
                485                 490                 495     
Leu Gly Leu Arg Lys Gln Thr His Asn Asn Ala Val Val Lys Met Leu
            500                 505                 510         
Pro Ser Phe Val Arg Arg Thr Pro Asp Gly Thr Glu Asn Gly Asp Phe
        515                 520                 525             
Leu Ala Leu Asp Leu Gly Gly Ala Asn Phe Arg Val Leu Leu Val Lys
    530                 535                 540                 
Ile Arg Ser Gly Lys Lys Arg Thr Val Glu Met His Asn Lys Ile Tyr
545                 550                 555                 560 
Ala Ile Pro Ile Glu Ile Met Gln Gly Thr Gly Glu Glu Leu Phe Asp
                565                 570                 575     
His Ile Val Ser Cys Ile Ser Asp Phe Leu Asp Tyr Met Gly Ile Lys
            580                 585                 590         
Gly Pro Arg Met Pro Leu Gly Phe Thr Phe Ser Phe Pro Cys Gln Gln
        595                 600                 605             
Thr Ser Leu Asp Ala Gly Ile Leu Ile Thr Trp Thr Lys Gly Phe Lys
    610                 615                 620                 
Ala Thr Asp Cys Val Gly His Asp Val Val Thr Leu Leu Arg Asp Ala
625                 630                 635                 640 
Ile Lys Arg Arg Glu Glu Phe Asp Leu Asp Val Val Ala Val Val Asn
                645                 650                 655     
Asp Thr Val Gly Thr Met Met Thr Cys Ala Tyr Glu Glu Pro Thr Cys
            660                 665                 670         
Glu Val Gly Leu Ile Val Gly Thr Gly Ser Asn Ala Cys Tyr Met Glu
        675                 680                 685             
Glu Met Lys Asn Val Glu Met Val Glu Gly Asp Gln Gly Gln Met Cys
    690                 695                 700                 
Ile Asn Met Glu Trp Gly Ala Phe Gly Asp Asn Gly Cys Leu Asp Asp
705                 710                 715                 720 
Ile Arg Thr His Tyr Asp Arg Leu Val Asp Glu Tyr Ser Leu Asn Ala
                725                 730                 735     
Gly Lys Gln Arg Tyr Glu Lys Met Ile Ser Gly Met Tyr Leu Gly Glu
            740                 745                 750         
Ile Val Arg Asn Ile Leu Ile Asp Phe Thr Lys Lys Gly Phe Leu Phe
        755                 760                 765             
Arg Gly Gln Ile Ser Glu Thr Leu Lys Thr Arg Gly Ile Phe Glu Thr
    770                 775                 780                 
Lys Phe Leu Ser Gln Ile Glu Ser Asp Arg Leu Ala Leu Leu Gln Val
785                 790                 795                 800 
Arg Ala Ile Leu Gln Gln Leu Gly Leu Asn Ser Thr Cys Asp Asp Ser
                805                 810                 815     
Ile Leu Val Lys Thr Val Cys Gly Val Val Ser Arg Arg Ala Ala Gln
            820                 825                 830         
Leu Cys Gly Ala Gly Met Ala Ala Val Val Asp Lys Ile Arg Glu Asn
        835                 840                 845             
Arg Gly Leu Asp Arg Leu Asn Val Thr Val Gly Val Asp Gly Thr Leu
    850                 855                 860                 
Tyr Lys Leu His Pro His Phe Ser Arg Ile Met His Gln Thr Val Lys
865                 870                 875                 880 
Glu Leu Ser Pro Lys Cys Asn Val Ser Phe Leu Leu Ser Glu Asp Gly
                885                 890                 895     
Ser Gly Lys Gly Ala Ala Leu Ile Thr Ala Val Gly Val Arg Leu Arg
            900                 905                 910         
Thr Glu Ala Ser Ser
        915         


<210> 800
<211> 2270
<212> PRT
<213> Homo sapiens

<400> 800
Met Leu Glu Gly Leu Val Ala Trp Val Leu Asn Thr Tyr Leu Gly Lys
 1               5                  10                  15      
Tyr Val Asn Asn Leu Asn Thr Asp Gln Leu Ser Val Ala Leu Leu Lys
            20                  25                  30          
Gly Ala Val Glu Leu Glu Asn Leu Pro Leu Lys Lys Asp Ala Leu Lys
        35                  40                  45              
Glu Leu Glu Leu Pro Phe Glu Val Lys Ala Gly Phe Ile Gly Lys Val
    50                  55                  60                  
Thr Leu Gln Ile Pro Phe Tyr Arg Pro His Val Asp Pro Trp Val Ile
65                  70                  75                  80  
Ser Ile Ser Ser Leu His Leu Ile Gly Ala Pro Glu Lys Ile Gln Asp
                85                  90                  95      
Phe Asn Asp Glu Lys Glu Lys Leu Leu Glu Arg Glu Arg Lys Lys Ala
            100                 105                 110         
Leu Leu Gln Ala Leu Glu Glu Lys Trp Lys Asn Asp Arg Gln Gln Lys
        115                 120                 125             
Gly Glu Ser Tyr Trp Tyr Ser Val Thr Ala Ser Val Val Thr Arg Ile
    130                 135                 140                 
Val Glu Asn Ile Glu Leu Lys Ile Gln Asp Val His Leu Arg Phe Glu
145                 150                 155                 160 
Asp Gly Val Thr Asn Pro Ser His Pro Phe Ala Phe Gly Ile Cys Ile
                165                 170                 175     
Lys Asn Val Ser Met Gln Asn Ala Val Asn Glu Pro Val Gln Lys Leu
            180                 185                 190         
Met Arg Lys Lys Gln Leu Asp Val Ala Glu Phe Ser Ile Tyr Trp Asp
        195                 200                 205             
Val Asp Cys Thr Leu Leu Gly Asp Leu Pro Gln Met Glu Leu Gln Glu
    210                 215                 220                 
Ala Met Ala Arg Ser Met Glu Ser Arg Ser His His Tyr Val Leu Glu
225                 230                 235                 240 
Pro Val Phe Ala Ser Ala Leu Leu Lys Arg Asn Cys Ser Lys Lys Pro
                245                 250                 255     
Leu Arg Ser Arg His Ser Pro Arg Ile Asp Cys Asp Ile Gln Leu Glu
            260                 265                 270         
Thr Ile Pro Leu Lys Leu Ser Gln Leu Gln Tyr Arg Gln Ile Met Glu
        275                 280                 285             
Phe Leu Lys Glu Leu Glu Arg Lys Glu Arg Gln Val Lys Phe Arg Arg
    290                 295                 300                 
Trp Lys Pro Lys Val Ala Ile Ser Lys Asn Cys Arg Glu Trp Trp Tyr
305                 310                 315                 320 
Phe Ala Leu Asn Ala Asn Leu Tyr Glu Ile Arg Glu Gln Arg Lys Arg
                325                 330                 335     
Cys Thr Trp Asp Phe Met Leu His Arg Ala Arg Asp Ala Val Ser Tyr
            340                 345                 350         
Thr Asp Lys Tyr Phe Asn Lys Leu Lys Gly Gly Leu Leu Ser Thr Asp
        355                 360                 365             
Asp Lys Glu Glu Met Cys Arg Ile Glu Glu Glu Gln Ser Phe Glu Glu
    370                 375                 380                 
Leu Lys Ile Leu Arg Glu Leu Val His Asp Arg Phe His Lys Gln Glu
385                 390                 395                 400 
Glu Leu Ala Glu Ser Leu Arg Glu Pro Gln Phe Asp Ser Pro Gly Ala
                405                 410                 415     
Cys Pro Gly Ala Pro Glu Pro Gly Gly Gly Ser Gly Met Leu Gln Tyr
            420                 425                 430         
Leu Gln Ser Trp Phe Pro Gly Trp Gly Gly Trp Tyr Gly Gln Gln Thr
        435                 440                 445             
Pro Glu Gly Asn Val Val Glu Gly Leu Ser Ala Glu Gln Gln Glu Gln
    450                 455                 460                 
Trp Ile Pro Glu Glu Ile Leu Gly Thr Glu Glu Phe Phe Asp Pro Thr
465                 470                 475                 480 
Ala Asp Ala Ser Cys Met Asn Thr Tyr Thr Lys Arg Asp His Val Phe
                485                 490                 495     
Ala Lys Leu Asn Leu Gln Leu Gln Arg Gly Thr Val Thr Leu Leu His
            500                 505                 510         
Lys Glu Gln Gly Thr Pro Gln Met Asn Glu Ser Ala Phe Met Gln Leu
        515                 520                 525             
Glu Phe Ser Asp Val Lys Leu Leu Ala Glu Ser Leu Pro Arg Arg Asn
    530                 535                 540                 
Ser Ser Leu Leu Ser Val Arg Leu Gly Gly Leu Phe Leu Arg Asp Leu
545                 550                 555                 560 
Ala Thr Glu Gly Thr Met Phe Pro Leu Leu Val Phe Pro Asn Pro Gln
                565                 570                 575     
Lys Glu Val Gly Arg Val Ser Gln Ser Phe Gly Leu Gln Thr Thr Ser
            580                 585                 590         
Ala Asp Arg Ser Asp His Tyr Pro Ala Ala Asp Pro Asp Gly Pro Val
        595                 600                 605             
Phe Glu Met Leu Tyr Glu Arg Asn Pro Ala His Ser His Phe Glu Arg
    610                 615                 620                 
Arg Leu Asn Val Ser Thr Arg Pro Leu Asn Ile Ile Tyr Asn Pro Gln
625                 630                 635                 640 
Ala Ile Lys Lys Val Ala Asp Phe Phe Tyr Lys Gly Lys Val His Thr
                645                 650                 655     
Ser Gly Phe Gly Tyr Gln Ser Glu Leu Glu Leu Arg Val Ala Glu Ala
            660                 665                 670         
Ala Arg Arg Gln Tyr Asn Lys Leu Lys Met Gln Thr Lys Ala Glu Ile
        675                 680                 685             
Arg Gln Thr Leu Asp Arg Leu Leu Val Gly Asp Phe Ile Glu Glu Ser
    690                 695                 700                 
Lys Arg Trp Thr Val Arg Leu Asp Ile Ser Ala Pro Gln Val Ile Phe
705                 710                 715                 720 
Pro Asp Asp Phe Lys Phe Lys Asn Pro Val Leu Val Val Val Asp Leu
                725                 730                 735     
Gly Arg Met Leu Leu Thr Asn Thr Gln Asp Asn Ser Arg Arg Lys Ser
            740                 745                 750         
Arg Asp Gly Ser Ala Ser Glu Glu Thr Gln Phe Ser Asp Asp Glu Tyr
        755                 760                 765             
Lys Thr Pro Leu Ala Thr Pro Pro Asn Thr Pro Pro Pro Glu Ser Ser
    770                 775                 780                 
Ser Ser Asn Gly Glu Lys Thr Pro Pro Phe Ser Gly Val Glu Phe Ser
785                 790                 795                 800 
Glu Glu Gln Leu Gln Ala His Leu Met Ser Thr Lys Met Tyr Glu Arg
                805                 810                 815     
Tyr Ser Leu Ser Phe Met Asp Leu Gln Ile Met Val Gly Arg Val Lys
            820                 825                 830         
Asp Asn Trp Lys His Val Gln Asp Ile Asp Val Gly Pro Thr His Val
        835                 840                 845             
Val Glu Lys Phe Asn Val His Leu Gln Leu Glu Arg Arg Leu Ile Tyr
    850                 855                 860                 
Thr Ser Asp Pro Lys Tyr Pro Gly Ala Val Leu Ser Gly Asn Leu Pro
865                 870                 875                 880 
Asp Leu Lys Ile His Ile Asn Glu Asp Lys Ile Ser Ala Leu Lys Asn
                885                 890                 895     
Cys Phe Ala Leu Leu Thr Thr Pro Glu Met Lys Thr Ser Asp Thr Gln
            900                 905                 910         
Ile Lys Glu Lys Ile Phe Pro Gln Glu Glu Gln Arg Gly Ser Leu Gln
        915                 920                 925             
Asp Ser Val Met Asn Leu Thr Gln Ser Ile Val Leu Leu Glu Gln His
    930                 935                 940                 
Thr Arg Glu Val Leu Val Glu Ser Gln Leu Leu Leu Ala Glu Phe Lys
945                 950                 955                 960 
Val Asn Cys Met Gln Leu Gly Val Glu Ser Asn Gly Arg Tyr Ile Ser
                965                 970                 975     
Val Leu Lys Val Phe Gly Thr Asn Ala His Phe Val Lys Arg Pro Tyr
            980                 985                 990         
Asp Ala Glu Val Ser Leu Thr Val His Gly Leu Leu Leu Val Asp Thr
        995                 1000                1005            
Met Gln Thr Tyr Gly Ala Asp Phe Asp Leu Leu Met Ala Ser His Lys
    1010                1015                1020                
Asn Leu Ser Phe Asp Ile Pro Thr Gly Ser Leu Arg Asp Ser Arg Ala
1025                1030                1035                1040
Gln Ser Pro Val Ser Gly Pro Asn Val Ala His Leu Thr Asp Gly Ala
                1045                1050                1055    
Thr Leu Asn Asp Arg Ser Ala Thr Ser Val Ser Leu Asp Lys Ile Leu
            1060                1065                1070        
Thr Lys Glu Gln Glu Ser Leu Ile Lys Leu Glu Tyr Gln Phe Val Ser
        1075                1080                1085            
Ser Glu Cys Pro Ser Met Asn Leu Asp Ser Thr Leu Gln Val Ile Ser
    1090                1095                1100                
Leu Gln Val Asn Asn Leu Asp Ile Ile Leu Asn Pro Glu Thr Ile Val
1105                1110                1115                1120
Glu Leu Ile Gly Phe Leu Gln Lys Ser Phe Pro Lys Glu Lys Asp Asp
                1125                1130                1135    
Leu Ser Pro Gln Pro Leu Met Thr Asp Phe Glu Arg Ser Phe Arg Glu
            1140                1145                1150        
Gln Gly Thr Tyr Gln Ser Thr Tyr Glu Gln Asn Thr Glu Val Ala Val
        1155                1160                1165            
Glu Ile His Arg Leu Asn Leu Leu Leu Leu Arg Thr Val Gly Met Ala
    1170                1175                1180                
Asn Arg Glu Lys Tyr Gly Arg Lys Ile Ala Thr Ala Ser Ile Gly Gly
1185                1190                1195                1200
Thr Lys Val Asn Val Ser Met Gly Ser Thr Phe Asp Met Asn Gly Ser
                1205                1210                1215    
Leu Gly Cys Leu Gln Leu Met Asp Leu Thr Gln Asp Asn Val Lys Asn
            1220                1225                1230        
Gln Tyr Val Val Ser Ile Gly Asn Ser Val Gly Tyr Glu Asn Ile Ile
        1235                1240                1245            
Ser Asp Ile Gly Tyr Phe Glu Ser Val Phe Val Arg Met Glu Asp Ala
    1250                1255                1260                
Ala Leu Thr Glu Ala Leu Ser Phe Thr Phe Val Glu Arg Ser Lys Gln
1265                1270                1275                1280
Glu Cys Phe Leu Asn Leu Lys Met Ala Ser Leu His Tyr Asn His Ser
                1285                1290                1295    
Ala Lys Phe Leu Lys Glu Leu Thr Leu Ser Met Asp Glu Leu Glu Glu
            1300                1305                1310        
Asn Phe Arg Gly Met Leu Lys Ser Ala Ala Thr Lys Val Thr Thr Val
        1315                1320                1325            
Leu Ala Thr Lys Thr Ala Glu Tyr Ser Glu Met Val Ser Leu Phe Glu
    1330                1335                1340                
Thr Pro Arg Lys Thr Arg Glu Pro Phe Ile Leu Glu Glu Asn Glu Ile
1345                1350                1355                1360
Tyr Gly Phe Asp Leu Ala Ser Ser His Leu Asp Thr Val Lys Leu Ile
                1365                1370                1375    
Leu Asn Ile Asn Ile Glu Ser Pro Val Val Ser Ile Pro Arg Lys Pro
            1380                1385                1390        
Gly Ser Pro Glu Leu Leu Val Gly His Leu Gly Gln Ile Phe Ile Gln
        1395                1400                1405            
Asn Phe Val Ala Gly Asp Asp Glu Ser Arg Ser Asp Arg Leu Gln Val
    1410                1415                1420                
Glu Ile Lys Asp Ile Lys Leu Tyr Ser Leu Asn Cys Thr Gln Leu Ala
1425                1430                1435                1440
Gly Arg Glu Ala Val Gly Ser Glu Gly Ser Arg Met Phe Cys Pro Pro
                1445                1450                1455    
Ser Gly Ser Gly Ser Ala Asn Ser Gln Glu Glu Ala His Phe Thr Arg
            1460                1465                1470        
His Asp Phe Phe Glu Ser Leu His Arg Gly Gln Ala Phe His Ile Leu
        1475                1480                1485            
Asn Asn Thr Thr Ile Gln Phe Lys Leu Glu Lys Ile Pro Ile Glu Arg
    1490                1495                1500                
Glu Ser Glu Leu Thr Phe Ser Leu Ser Pro Asp Asp Leu Gly Thr Ser
1505                1510                1515                1520
Ser Ile Met Lys Ile Glu Gly Lys Phe Val Asn Pro Val Gln Val Val
                1525                1530                1535    
Leu Ala Lys His Val Tyr Glu Gln Val Leu Gln Thr Leu Asp Asn Leu
            1540                1545                1550        
Val Tyr Ser Glu Asp Leu Asn Lys Tyr Pro Ala Ser Ala Thr Ser Ser
        1555                1560                1565            
Pro Cys Pro Asp Ser Pro Leu Pro Pro Leu Ser Thr Cys Gly Glu Ser
    1570                1575                1580                
Ser Val Glu Arg Lys Glu Asn Gly Leu Phe Ser His Ser Ser Leu Ser
1585                1590                1595                1600
Asn Thr Ser Gln Lys Ser Leu Ser Val Lys Glu Val Lys Ser Phe Thr
                1605                1610                1615    
Gln Ile Gln Ala Thr Phe Cys Ile Ser Glu Leu Gln Val Gln Leu Ser
            1620                1625                1630        
Gly Asp Leu Thr Leu Gly Ala Gln Gly Leu Val Ser Leu Lys Phe Gln
        1635                1640                1645            
Asp Phe Glu Val Glu Phe Ser Lys Asp His Pro Gln Thr Leu Ser Ile
    1650                1655                1660                
Gln Ile Ala Leu His Ser Leu Leu Met Glu Asp Leu Leu Glu Lys Asn
1665                1670                1675                1680
Pro Asp Ser Lys Tyr Lys Asn Leu Met Val Ser Arg Gly Ala Pro Lys
                1685                1690                1695    
Pro Ser Ser Leu Ala Gln Lys Glu Tyr Leu Ser Gln Ser Cys Pro Ser
            1700                1705                1710        
Val Ser Asn Val Glu Tyr Pro Asp Met Pro Arg Ser Leu Pro Ser His
        1715                1720                1725            
Met Glu Glu Ala Pro Asn Val Phe Gln Leu Tyr Gln Arg Pro Thr Ser
    1730                1735                1740                
Ala Ser Arg Lys Lys Gln Lys Glu Val Gln Asp Lys Asp Tyr Pro Leu
1745                1750                1755                1760
Thr Pro Pro Pro Ser Pro Thr Val Asp Glu Pro Lys Ile Leu Val Gly
                1765                1770                1775    
Lys Ser Lys Phe Asp Asp Ser Leu Val His Ile Asn Ile Phe Leu Val
            1780                1785                1790        
Asp Lys Lys His Pro Glu Phe Ser Ser Ser Tyr Asn Arg Val Asn Arg
        1795                1800                1805            
Ser Ile Asp Val Asp Phe Asn Cys Leu Asp Val Leu Ile Thr Leu Gln
    1810                1815                1820                
Thr Trp Val Val Ile Leu Asp Phe Phe Gly Ile Gly Ser Thr Ala Asp
1825                1830                1835                1840
Asn His Ala Met Arg Leu Pro Pro Glu Gly Ile Leu His Asn Val Lys
                1845                1850                1855    
Leu Glu Pro His Ala Ser Met Glu Ser Gly Leu Gln Asp Pro Val Asn
            1860                1865                1870        
Thr Lys Leu Asp Leu Lys Val His Ser Leu Ser Leu Val Leu Asn Lys
        1875                1880                1885            
Thr Thr Ser Glu Leu Ala Lys Ala Asn Val Ser Lys Leu Val Ala His
    1890                1895                1900                
Leu Glu Met Ile Glu Gly Asp Leu Ala Leu Gln Gly Ser Ile Gly Ser
1905                1910                1915                1920
Leu Ser Leu Ser Asp Leu Thr Cys His Gly Glu Phe Tyr Arg Glu Arg
                1925                1930                1935    
Phe Thr Thr Ser Gly Glu Glu Ala Leu Ile Phe Gln Thr Phe Lys Tyr
            1940                1945                1950        
Gly Arg Pro Asp Pro Leu Leu Arg Arg Glu His Asp Ile Arg Val Ser
        1955                1960                1965            
Leu Arg Met Ala Ser Val Gln Tyr Val His Thr Gln Arg Phe Gln Ala
    1970                1975                1980                
Glu Val Val Ala Phe Ile Gln His Phe Thr Gln Leu Gln Asp Val Leu
1985                1990                1995                2000
Gly Arg Gln Arg Ala Ala Ile Glu Gly Gln Thr Val Arg Asp Gln Ala
                2005                2010                2015    
Gln Arg Cys Ser Arg Val Leu Leu Asp Ile Glu Ala Gly Ala Pro Val
            2020                2025                2030        
Leu Leu Ile Pro Glu Ser Ser Arg Ser Asn Asn Leu Ile Val Ala Asn
        2035                2040                2045            
Leu Gly Lys Leu Lys Val Lys Asn Lys Phe Leu Phe Ala Gly Phe Pro
    2050                2055                2060                
Gly Thr Phe Ser Leu Gln Asp Lys Glu Ser Val Pro Ser Ala Ser Pro
2065                2070                2075                2080
Thr Gly Ile Pro Lys His Ser Leu Arg Lys Thr Thr Ser Thr Glu Glu
                2085                2090                2095    
Pro Arg Gly Thr His Ser Gln Gly Gln Phe Thr Met Pro Leu Ala Gly
            2100                2105                2110        
Met Ser Leu Gly Ser Leu Lys Ser Glu Phe Val Pro Ser Thr Ser Thr
        2115                2120                2125            
Lys Gln Gln Gly Pro Gln Pro Thr Leu Ser Val Gly Gln Glu Ser Ser
    2130                2135                2140                
Ser Pro Glu Asp His Val Cys Leu Leu Asp Cys Val Val Val Asp Leu
2145                2150                2155                2160
Gln Asp Met Asp Ile Phe Ala Ala Glu Arg His Pro Arg Glu Tyr Ser
                2165                2170                2175    
Lys Ala Pro Glu Asp Ser Ser Gly Asp Leu Ile Phe Pro Ser Tyr Phe
            2180                2185                2190        
Val Arg Gln Thr Gly Gly Ser Leu Leu Thr Glu Pro Cys Arg Leu Lys
        2195                2200                2205            
Leu Gln Val Glu Arg Asn Leu Asp Lys Glu Ile Ser His Thr Val Pro
    2210                2215                2220                
Asp Ile Ser Ile His Gly Asn Leu Ser Ser Val His Cys Ser Leu Asp
2225                2230                2235                2240
Leu Tyr Lys Tyr Lys Leu Ile Arg Gly Leu Leu Glu Asn Asn Leu Gly
                2245                2250                2255    
Glu Pro Ile Glu Glu Phe Met Arg Pro Tyr Asp Leu Gln Asp
            2260                2265                2270


<210> 801
<211> 382
<212> PRT
<213> Homo sapiens

<400> 801
Met Met Leu Lys Gly Ile Thr Arg Leu Ile Ser Arg Ile His Lys Leu
 1               5                  10                  15      
Asp Pro Gly Arg Phe Leu His Met Gly Thr Gln Ala Arg Gln Ser Ile
            20                  25                  30          
Ala Ala His Leu Asp Asn Gln Val Pro Val Glu Ser Pro Arg Ala Ile
        35                  40                  45              
Ser Arg Thr Asn Glu Asn Asp Pro Ala Lys His Gly Asp Gln His Glu
    50                  55                  60                  
Gly Gln His Tyr Asn Ile Ser Pro Gln Asp Leu Glu Thr Val Phe Pro
65                  70                  75                  80  
His Gly Leu Pro Pro Arg Phe Val Met Gln Val Lys Thr Phe Ser Glu
                85                  90                  95      
Ala Cys Leu Met Val Arg Lys Pro Ala Leu Glu Leu Leu His Tyr Leu
            100                 105                 110         
Lys Asn Thr Ser Phe Ala Tyr Pro Ala Ile Arg Tyr Leu Leu Tyr Gly
        115                 120                 125             
Glu Lys Gly Thr Gly Lys Thr Leu Ser Leu Cys His Val Ile His Phe
    130                 135                 140                 
Cys Ala Lys Gln Asp Trp Leu Ile Leu His Ile Pro Asp Ala His Leu
145                 150                 155                 160 
Trp Val Lys Asn Cys Arg Asp Leu Leu Gln Ser Ser Tyr Asn Lys Gln
                165                 170                 175     
Arg Phe Asp Gln Pro Leu Glu Ala Ser Thr Trp Leu Lys Asn Phe Lys
            180                 185                 190         
Thr Thr Asn Glu Arg Phe Leu Asn Gln Ile Lys Val Gln Glu Lys Tyr
        195                 200                 205             
Val Trp Asn Lys Arg Glu Ser Thr Glu Lys Gly Ser Pro Leu Gly Glu
    210                 215                 220                 
Val Val Glu Gln Gly Ile Thr Arg Val Arg Asn Ala Thr Asp Ala Val
225                 230                 235                 240 
Gly Ile Val Leu Lys Glu Leu Lys Arg Gln Ser Ser Leu Gly Met Phe
                245                 250                 255     
His Leu Leu Val Ala Val Asp Gly Ile Asn Ala Leu Trp Gly Arg Thr
            260                 265                 270         
Thr Leu Lys Arg Glu Asp Lys Ser Pro Ile Ala Pro Glu Glu Leu Ala
        275                 280                 285             
Leu Val His Asn Leu Arg Lys Met Met Lys Asn Asp Trp His Gly Gly
    290                 295                 300                 
Ala Ile Val Ser Ala Leu Ser Gln Thr Gly Ser Leu Phe Lys Pro Arg
305                 310                 315                 320 
Lys Ala Tyr Leu Pro Gln Glu Leu Leu Gly Lys Glu Gly Phe Asp Ala
                325                 330                 335     
Leu Asp Pro Phe Ile Pro Ile Leu Val Ser Asn Tyr Thr Gln Arg Asn
            340                 345                 350         
Leu Lys Val Val Phe Ser Ile Ile Trp Lys Thr Ile Gly Phe Asn Met
        355                 360                 365             
Arg Lys Leu Leu Gln Lys Lys Gly Lys Lys Ser Cys Cys Ser
    370                 375                 380         


<210> 802
<211> 334
<212> PRT
<213> Homo sapiens

<400> 802
Met Ser Glu Pro Ile Arg Val Leu Val Thr Gly Ala Ala Gly Gln Ile
 1               5                  10                  15      
Ala Tyr Ser Leu Leu Tyr Ser Ile Gly Asn Gly Ser Val Phe Gly Lys
            20                  25                  30          
Asp Gln Pro Ile Ile Leu Val Leu Leu Asp Ile Thr Pro Met Met Gly
        35                  40                  45              
Val Leu Asp Gly Val Leu Met Glu Leu Gln Asp Cys Ala Leu Pro Leu
    50                  55                  60                  
Leu Lys Asp Val Ile Ala Thr Asp Lys Glu Asp Val Ala Phe Lys Asp
65                  70                  75                  80  
Leu Asp Val Ala Ile Leu Val Gly Ser Met Pro Arg Arg Glu Gly Met
                85                  90                  95      
Glu Arg Lys Asp Leu Leu Lys Ala Ser Val Lys Ile Phe Lys Ser Gln
            100                 105                 110         
Gly Ala Ala Leu Asp Lys Tyr Ala Lys Lys Ser Val Lys Val Ile Val
        115                 120                 125             
Val Gly Asn Pro Ala Asn Thr Asn Cys Leu Thr Ala Ser Lys Ser Ala
    130                 135                 140                 
Pro Ser Ile Pro Lys Glu Asn Phe Ser Cys Leu Thr Arg Leu Asp His
145                 150                 155                 160 
Asn Arg Ala Lys Ala Gln Ile Ala Leu Lys Leu Gly Val Thr Ala Asn
                165                 170                 175     
Asp Val Lys Asn Val Ile Ile Trp Gly Asn His Ser Thr Thr Gln Tyr
            180                 185                 190         
Pro Asp Val Asn His Ala Lys Val Lys Leu Gln Gly Glu Glu Val Gly
        195                 200                 205             
Val Tyr Glu Ala Leu Glu Asp Asp Ser Trp Leu Lys Gly Glu Phe Val
    210                 215                 220                 
Thr Thr Val Gln Gln Arg Ser Ala Ala Val Ile Lys Ala Arg Lys Leu
225                 230                 235                 240 
Ser Ser Ala Met Ser Ala Ala Lys Ala Ile Cys Asp His Val Arg Asp
                245                 250                 255     
Ile Trp Phe Gly Thr Pro Glu Gly Glu Phe Val Ser Met Gly Val Ile
            260                 265                 270         
Ser Asp Gly Asn Ser Tyr Gly Val Pro Asp Asp Leu Leu Tyr Ser Phe
        275                 280                 285             
Pro Val Val Ile Lys Asn Lys Thr Arg Lys Phe Val Glu Gly Leu Pro
    290                 295                 300                 
Ile Asn Asp Phe Ser Arg Glu Lys Met Asp Leu Thr Ala Lys Glu Leu
305                 310                 315                 320 
Thr Glu Glu Lys Glu Ser Ala Phe Glu Phe Leu Ser Ser Ala
                325                 330                 


<210> 803
<211> 1086
<212> PRT
<213> Homo sapiens

<400> 803
Met Ala Asn Leu Leu Lys Thr Val Val Thr Gly Cys Ser Cys Pro Leu
 1               5                  10                  15      
Leu Ser Asn Leu Gly Ser Cys Lys Gly Leu Arg Val Lys Lys Asp Phe
            20                  25                  30          
Leu Arg Thr Phe Tyr Thr His Gln Glu Leu Trp Cys Lys Ala Pro Val
        35                  40                  45              
Lys Pro Gly Ile Pro Tyr Lys Gln Leu Thr Val Gly Val Pro Lys Glu
    50                  55                  60                  
Ile Phe Gln Asn Glu Lys Arg Val Ala Leu Ser Pro Ala Gly Val Gln
65                  70                  75                  80  
Asn Leu Val Lys Gln Gly Phe Asn Val Val Val Glu Ser Gly Ala Gly
                85                  90                  95      
Glu Ala Ser Lys Phe Ser Asp Asp His Tyr Arg Val Ala Gly Ala Gln
            100                 105                 110         
Ile Gln Gly Ala Lys Glu Val Leu Ala Ser Asp Leu Val Val Lys Val
        115                 120                 125             
Arg Ala Pro Met Val Asn Pro Thr Leu Gly Val His Glu Ala Asp Leu
    130                 135                 140                 
Leu Lys Thr Ser Gly Thr Leu Ile Ser Phe Ile Tyr Pro Ala Gln Asn
145                 150                 155                 160 
Pro Glu Leu Leu Asn Lys Leu Ser Gln Arg Lys Thr Thr Val Leu Ala
                165                 170                 175     
Met Asp Gln Val Pro Arg Val Thr Ile Ala Gln Gly Tyr Asp Ala Leu
            180                 185                 190         
Ser Ser Met Ala Asn Ile Ala Gly Tyr Lys Ala Val Val Leu Ala Ala
        195                 200                 205             
Asn His Phe Gly Arg Phe Phe Thr Gly Gln Ile Thr Ala Ala Gly Lys
    210                 215                 220                 
Val Pro Pro Ala Lys Ile Leu Ile Val Gly Gly Gly Val Ala Gly Leu
225                 230                 235                 240 
Ala Ser Ala Gly Ala Glu Lys Ser Met Gly Ala Ile Val Arg Gly Phe
                245                 250                 255     
Asp Thr Arg Ala Ala Ser Leu Glu Gln Phe Lys Ser Leu Gly Ala Glu
            260                 265                 270         
Pro Leu Glu Val Asp Leu Lys Glu Ser Gly Glu Gly Gln Gly Gly Tyr
        275                 280                 285             
Ala Lys Glu Met Ser Lys Glu Phe Ile Glu Ala Glu Met Lys Leu Phe
    290                 295                 300                 
Ala Gln Gln Cys Lys Glu Val Asp Ile Leu Ile Ser Thr Ala Leu Ile
305                 310                 315                 320 
Pro Gly Lys Lys Ala Pro Val Leu Phe Asn Lys Glu Met Ile Glu Ser
                325                 330                 335     
Met Lys Glu Gly Ser Val Val Val Asp Leu Ala Ala Glu Ala Gly Gly
            340                 345                 350         
Asn Phe Glu Thr Thr Lys Pro Gly Glu Leu Tyr Ile His Lys Gly Ile
        355                 360                 365             
Thr His Ile Gly Tyr Thr Asp Leu Pro Ser Arg Met Ala Thr Gln Ala
    370                 375                 380                 
Ser Thr Leu Tyr Ser Asn Asn Ile Thr Lys Leu Leu Lys Ala Ile Ser
385                 390                 395                 400 
Pro Asp Lys Asp Asn Phe Tyr Phe Asp Val Lys Asp Asp Phe Asp Phe
                405                 410                 415     
Gly Thr Met Gly His Val Ile Arg Gly Thr Val Val Met Lys Asp Gly
            420                 425                 430         
Lys Val Ile Phe Pro Ala Pro Thr Pro Lys Asn Ile Pro Gln Gly Ala
        435                 440                 445             
Pro Val Lys Gln Lys Thr Val Ala Glu Leu Glu Ala Glu Lys Ala Ala
    450                 455                 460                 
Thr Ile Thr Pro Phe Arg Lys Thr Met Ser Thr Ala Ser Ala Tyr Thr
465                 470                 475                 480 
Ala Gly Leu Thr Gly Ile Leu Gly Leu Gly Ile Ala Ala Pro Asn Leu
                485                 490                 495     
Ala Phe Ser Gln Met Val Thr Thr Phe Gly Leu Ala Gly Ile Val Gly
            500                 505                 510         
Tyr His Thr Val Trp Gly Val Thr Pro Ala Leu His Ser Pro Leu Met
        515                 520                 525             
Ser Val Thr Asn Ala Ile Ser Gly Leu Thr Ala Val Gly Gly Leu Ala
    530                 535                 540                 
Leu Met Gly Gly His Leu Tyr Pro Ser Thr Thr Ser Gln Gly Leu Ala
545                 550                 555                 560 
Ala Leu Ala Ala Phe Ile Ser Ser Val Asn Ile Ala Gly Gly Phe Leu
                565                 570                 575     
Val Thr Gln Arg Met Leu Asp Met Phe Lys Arg Pro Thr Asp Pro Pro
            580                 585                 590         
Glu Tyr Asn Tyr Leu Tyr Leu Leu Pro Ala Gly Thr Phe Val Gly Gly
        595                 600                 605             
Tyr Leu Ala Ala Leu Tyr Ser Gly Tyr Asn Ile Glu Gln Ile Met Tyr
    610                 615                 620                 
Leu Gly Ser Gly Leu Cys Cys Val Gly Ala Leu Ala Gly Leu Ser Thr
625                 630                 635                 640 
Gln Gly Thr Ala Arg Leu Gly Asn Ala Leu Gly Met Ile Gly Val Ala
                645                 650                 655     
Gly Gly Leu Ala Ala Thr Leu Gly Val Leu Lys Pro Gly Pro Glu Leu
            660                 665                 670         
Leu Ala Gln Met Ser Gly Ala Met Ala Leu Gly Gly Thr Ile Gly Leu
        675                 680                 685             
Thr Ile Ala Lys Arg Ile Gln Ile Ser Asp Leu Pro Gln Leu Val Ala
    690                 695                 700                 
Ala Ser His Ser Leu Val Gly Leu Ala Ala Val Leu Thr Cys Ile Ala
705                 710                 715                 720 
Glu Tyr Ile Ile Glu Tyr Pro His Phe Ala Pro Asp Ala Ala Ala Asn
                725                 730                 735     
Leu Thr Lys Ile Val Ala Tyr Leu Gly Thr Tyr Ile Gly Gly Val Thr
            740                 745                 750         
Phe Ser Gly Ser Leu Ile Ala Tyr Gly Lys Leu Gln Gly Leu Leu Lys
        755                 760                 765             
Ser Ala Pro Leu Leu Leu Pro Gly Arg His Leu Leu Asn Ala Gly Leu
    770                 775                 780                 
Leu Ala Ala Ser Val Gly Gly Ile Ile Pro Phe Met Val Asp Pro Ser
785                 790                 795                 800 
Phe Thr Thr Gly Ile Thr Cys Leu Gly Ser Val Ser Ala Leu Ser Ala
                805                 810                 815     
Val Met Gly Val Thr Leu Thr Ala Ala Ile Gly Gly Ala Asp Met Pro
            820                 825                 830         
Val Val Ile Thr Val Leu Asn Ser Tyr Ser Gly Trp Ala Leu Cys Ala
        835                 840                 845             
Glu Gly Phe Leu Leu Asn Asn Asn Leu Leu Thr Ile Val Gly Ala Leu
    850                 855                 860                 
Ile Gly Ser Ser Gly Ala Pro Leu Ser Tyr Ile Met Cys Val Ala Met
865                 870                 875                 880 
Asn Arg Ser Leu Ala Asn Val Ile Leu Gly Gly Tyr Gly Thr Thr Ser
                885                 890                 895     
Thr Ala Gly Gly Lys Pro Met Glu Ile Ser Gly Thr His Thr Glu Ile
            900                 905                 910         
Asn Leu Asp Asn Ala Ile Asp Met Ile Arg Glu Ala Asn Ser Ile Ile
        915                 920                 925             
Phe Thr Pro Gly Tyr Gly Leu Cys Ala Ala Lys Ala Gln Tyr Pro Ile
    930                 935                 940                 
Ala Asp Leu Val Lys Met Leu Thr Glu Gln Gly Lys Lys Val Arg Phe
945                 950                 955                 960 
Gly Ile His Pro Val Ala Gly Arg Met Pro Gly Gln Leu Asn Val Leu
                965                 970                 975     
Leu Ala Glu Ala Gly Val Pro Tyr Asp Ile Val Leu Glu Met Asp Glu
            980                 985                 990         
Ile Asn His Asp Phe Pro Asp Thr Asp Leu Val Leu Val Ile Gly Ala
        995                 1000                1005            
Asn Asp Thr Val Asn Ser Ala Ala Gln Glu Asp Pro Asn Ser Ile Ile
    1010                1015                1020                
Ala Gly Met Pro Val Leu Glu Val Trp Lys Ser Lys Gln Val Ile Val
1025                1030                1035                1040
Met Lys Arg Ser Leu Gly Val Gly Tyr Ala Ala Val Asp Asn Pro Ile
                1045                1050                1055    
Phe Tyr Lys Pro Asn Thr Ala Met Leu Leu Gly Asp Ala Lys Lys Thr
            1060                1065                1070        
Cys Asp Ala Leu Gln Ala Lys Val Arg Glu Ser Tyr Gln Lys
        1075                1080                1085    


<210> 804
<211> 178
<212> PRT
<213> Homo sapiens

<400> 804
Arg Asn Ile Ile Phe Cys Ser Val Val Leu Gly Thr Phe Ile Cys Gln
 1               5                  10                  15      
Ile Phe Ile Val Glu Phe Gly Gly Lys Pro Phe Ser Cys Thr Ser Leu
            20                  25                  30          
Ser Leu Ser Gln Trp Leu Trp Cys Leu Phe Ile Gly Ile Gly Glu Leu
        35                  40                  45              
Leu Trp Gly Gln Phe Ile Ser Ala Ile Pro Thr Arg Ser Leu Lys Phe
    50                  55                  60                  
Leu Lys Glu Ala Gly His Gly Thr Thr Lys Glu Glu Ile Thr Lys Asp
65                  70                  75                  80  
Ala Glu Gly Leu Asp Glu Ile Asp His Ala Glu Met Glu Leu Arg Arg
                85                  90                  95      
Gly Gln Ile Leu Trp Phe Arg Gly Leu Asn Arg Ile Gln Thr Gln Ile
            100                 105                 110         
Asp Val Ile Asn Thr Phe Gln Thr Gly Ala Ser Phe Lys Gly Val Leu
        115                 120                 125             
Arg Arg Gln Asn Met Gly Gln His Leu Asp Val Lys Leu Val Pro Ser
    130                 135                 140                 
Ser Ser Tyr Val Ala Val Ala Pro Val Lys Ser Ser Pro Thr Thr Ser
145                 150                 155                 160 
Val Pro Ala Val Ser Ser Pro Pro Met Gly Asn Gln Ser Gly Gln Ser
                165                 170                 175     
Val Pro
        


<210> 805
<211> 1442
<212> PRT
<213> Homo sapiens

<400> 805
Met Gly Gly Asp Ala Pro Thr Met Ala Arg Ala Gln Ala Leu Val Leu
 1               5                  10                  15      
Glu Leu Thr Phe Gln Leu Cys Ala Pro Glu Thr Glu Thr Pro Glu Val
            20                  25                  30          
Gly Cys Thr Phe Glu Glu Gly Ser Asp Pro Ala Val Pro Cys Glu Tyr
        35                  40                  45              
Ser Gln Ala Gln Tyr Asp Asp Phe Gln Trp Asp Pro Gly Ser Pro Ala
    50                  55                  60                  
Asp Leu Pro His Gly Ser Tyr Leu Met Val Asn Thr Ser Gln His Ala
65                  70                  75                  80  
Pro Gly Gln Arg Ala His Val Ile Phe Gln Ser Leu Ser Glu Asn Asp
                85                  90                  95      
Thr His Cys Val Gln Phe Ser Tyr Phe Leu Tyr Ser Arg Asp Gly His
            100                 105                 110         
Ser Pro Gly Thr Leu Gly Val Tyr Val Arg Val Asn Gly Gly Pro Leu
        115                 120                 125             
Gly Ser Ala Val Trp Asn Met Thr Gly Ser His Gly Arg Gln Trp His
    130                 135                 140                 
Gln Ala Glu Leu Ala Val Ser Thr Phe Trp Pro Asn Glu Tyr Gln Val
145                 150                 155                 160 
Leu Phe Glu Ala Leu Ile Ser Pro Asp Arg Arg Gly Tyr Met Gly Leu
                165                 170                 175     
Asp Asp Ile Cys Ile Leu Ser Tyr Pro Cys Ala Lys Ala Pro His Phe
            180                 185                 190         
Ser Arg Leu Gly Asp Val Glu Val Asn Ala Gly Gln Asn Ala Ser Phe
        195                 200                 205             
Gln Cys Met Ala Ala Gly Arg Ala Glu Ala Glu Arg Phe Leu Leu Gln
    210                 215                 220                 
Arg Gln Ser Gly Ala Leu Val Pro Ala Ala Gly Val Arg His Ile Ser
225                 230                 235                 240 
His Arg Ser Phe Leu Ala Thr Phe Pro Leu Ala Ala Val Ser Arg Ala
                245                 250                 255     
Glu Gln Asp Leu Tyr Arg Cys Val Ser Gln Ala Pro Arg Gly Arg Gly
            260                 265                 270         
Thr Ser Leu Asn Phe Ala Glu Phe Met Val Lys Glu Pro Pro Thr Pro
        275                 280                 285             
Ile Ala Pro Pro Gln Leu Leu Arg Ala Gly Pro Thr Tyr Leu Ile Ile
    290                 295                 300                 
Gln Leu Asn Thr Asn Ser Ile Ile Gly Asp Gly Pro Ile Val Arg Lys
305                 310                 315                 320 
Glu Ile Glu Tyr Arg Met Ala Arg Gly Pro Trp Ala Glu Val His Ala
                325                 330                 335     
Val Ser Leu Gln Thr Tyr Lys Leu Trp His Leu Asp Pro Asp Thr Glu
            340                 345                 350         
Tyr Glu Ile Ser Val Leu Leu Thr Arg Pro Gly Asp Gly Gly Thr Gly
        355                 360                 365             
Arg Leu Gly Pro Pro Phe Ile Ser Arg Thr Lys Cys Ala Glu Pro Met
    370                 375                 380                 
Arg Ala Pro Lys Gly Leu Ala Phe Ala Glu Ile Gln Ala Arg Gln Leu
385                 390                 395                 400 
Thr Leu Gln Trp Glu Pro Leu Gly Tyr Asn Val Thr Arg Cys His Thr
                405                 410                 415     
Tyr Thr Val Ser Leu Cys Tyr His Tyr Thr Leu Gly Ser Ser His Asn
            420                 425                 430         
Gln Thr Ile Pro Arg Val Cys Glu Asp Arg Ala Arg Cys Gln Pro Leu
        435                 440                 445             
His His Glu Glu Pro Ala Ala Leu Ser Glu Arg Ser Arg Glu Val Val
    450                 455                 460                 
Leu Thr Asn Pro Glu Gly Arg Lys Glu Gly Lys Glu Val Thr Phe Gln
465                 470                 475                 480 
Thr Asp Glu Asp Val Pro Ser Gly Ile Ala Ala Glu Ser Leu Thr Phe
                485                 490                 495     
Thr Pro Leu Glu Asp Met Ile Phe Leu Lys Trp Glu Glu Pro Gln Glu
            500                 505                 510         
Pro Asn Gly Leu Ile Thr Gln Tyr Glu Ile Ser Tyr Gln Ser Ile Glu
        515                 520                 525             
Ser Ser Asp Pro Ala Val Asn Val Gln Ala Thr Ser Thr Ile Ser Lys
    530                 535                 540                 
Leu Arg Asn Glu Thr Tyr His Val Phe Ser Asn Leu His Pro Gly Thr
545                 550                 555                 560 
Thr Tyr Leu Phe Ser Val Gly Ala Arg Thr Gly Lys Gly Phe Gly Gln
                565                 570                 575     
Ala Ala Leu Thr Glu Ile Thr Thr Tyr Ile Ser Ala Pro Ser Leu Asp
            580                 585                 590         
Tyr Ala Asp Met Pro Ser Pro Leu Gly Glu Ser Glu Asn Asn Ile Thr
        595                 600                 605             
Val Leu Leu Arg Pro Ala Gln Gly Arg Gly Ala Pro Ile Ser Val Tyr
    610                 615                 620                 
Gln Val Ile Val Glu Glu Glu Gln Gly Ser Arg Arg Leu Arg Arg Glu
625                 630                 635                 640 
Pro Gly Gly Gln Asp Cys Phe Pro Val Pro Leu Thr Phe Glu Ala Ala
                645                 650                 655     
Leu Ala Arg Gly Leu Val Asp Tyr Phe Gly Ala Glu Leu Ala Ala Ser
            660                 665                 670         
Ser Leu Pro Glu Ala Met Pro Phe Thr Val Gly Asp Asn Lys Thr Tyr
        675                 680                 685             
Arg Gly Phe Trp Asn Pro Pro Leu Glu Pro Arg Lys Ala Tyr Leu Ile
    690                 695                 700                 
Tyr Phe Gln Ala Ala Ser His Leu Lys Gly Glu Thr Arg Leu Asn Cys
705                 710                 715                 720 
Ile Arg Ile Ala Arg Lys Ala Ala Cys Lys Glu Ser Lys Arg Pro Leu
                725                 730                 735     
Glu Val Ser Gln Arg Ser Glu Glu Met Gly Leu Ile Leu Gly Ile Cys
            740                 745                 750         
Ala Gly Gly Leu Ala Val Leu Ile Leu Leu Leu Gly Ala Ile Ile Val
        755                 760                 765             
Ile Ile Arg Lys Gly Arg Asp His Tyr Ala Tyr Ser Tyr Tyr Pro Lys
    770                 775                 780                 
Pro Val Asn Met Thr Lys Ala Thr Val Asn Tyr Arg Gln Glu Lys Thr
785                 790                 795                 800 
His Met Met Ser Ala Val Asp Arg Ser Phe Thr Asp Gln Ser Thr Leu
                805                 810                 815     
Gln Pro Pro Gly Leu Ser Phe Met Asp Thr His Gly Tyr Ser Thr Arg
            820                 825                 830         
Gly Glu Gln Arg Ser Gly Gly Val Thr Glu Ala Ser Ser Leu Leu Gly
        835                 840                 845             
Gly Ser Pro Arg Arg Pro Cys Gly Arg Lys Gly Ser Pro Tyr His Thr
    850                 855                 860                 
Val Gln Leu His Pro Ala Val Arg Val Ala Asp Leu Leu Gln His Ile
865                 870                 875                 880 
Asn Gln Met Lys Thr Ala Glu Gly Tyr Gly Phe Lys Gln Glu Tyr Glu
                885                 890                 895     
Ser Phe Phe Glu Gly Trp Asp Ala Thr Lys Lys Lys Asp Lys Val Lys
            900                 905                 910         
Gly Ser Arg Gln Glu Pro Met Pro Ala Tyr Asp Arg His Arg Val Lys
        915                 920                 925             
Leu His Pro Met Leu Gly Asp Pro Asn Ala Asp Tyr Ile Asn Ala Asn
    930                 935                 940                 
Tyr Ile Asp Gly Tyr His Arg Ser Asn His Phe Ile Ala Thr Gln Gly
945                 950                 955                 960 
Pro Lys Pro Glu Met Val Tyr Asp Phe Trp Arg Met Val Trp Gln Glu
                965                 970                 975     
His Cys Ser Ser Ile Val Met Ile Thr Lys Leu Val Glu Val Ala Gly
            980                 985                 990         
Cys Lys Cys Ser Arg Tyr Trp Pro Glu Asp Ser Asp Thr Tyr Gly Asp
        995                 1000                1005            
Ile Lys Ile Met Leu Val Lys Thr Glu Thr Leu Ala Glu Tyr Val Val
    1010                1015                1020                
Arg Thr Phe Ala Leu Glu Arg Arg Gly Tyr Ser Ala Arg Tyr Glu Val
1025                1030                1035                1040
Arg Gln Phe His Phe Thr Ala Trp Pro Glu His Gly Val Pro Tyr His
                1045                1050                1055    
Thr Thr Gly Leu Leu Ala Phe Ile Arg Arg Val Lys Ala Ser Thr Pro
            1060                1065                1070        
Pro Asp Ala Gly Pro Ile Val Ile His Cys Ser Ala Gly Thr Gly Arg
        1075                1080                1085            
Thr Gly Cys Tyr Ile Val Leu Asp Val Met Leu Asp Met Ala Glu Cys
    1090                1095                1100                
Glu Gly Val Val Asp Ile Tyr Asn Cys Val Lys Thr Leu Cys Ser Arg
1105                1110                1115                1120
Cys Val Asn Met Ile Gln Thr Glu Glu Gln Tyr Ile Phe Ile His Asp
                1125                1130                1135    
Ala Ile Leu Glu Ala Cys Leu Cys Gly Glu Thr Thr Ile Pro Val Ser
            1140                1145                1150        
Glu Phe Lys Ala Thr Tyr Lys Glu Met Ile Arg Ile Asp Pro Gln Ser
        1155                1160                1165            
Asn Ser Ser Gln Leu Arg Glu Glu Phe Gln Thr Leu Asn Ser Val Thr
    1170                1175                1180                
Pro Pro Leu Asp Val Glu Glu Tyr Ser Ile Ala Leu Leu Pro Arg Asn
1185                1190                1195                1200
Arg Asp Lys Asn Arg Ser Met Asp Val Leu Pro Pro Asp Arg Cys Leu
                1205                1210                1215    
Pro Phe Leu Ile Ser Thr Asp Gly Asp Ser Asn Asn Tyr Ile Asn Ala
            1220                1225                1230        
Ala Leu Thr Asp Ser Tyr Thr Arg Ser Ala Ala Phe Ile Val Thr Leu
        1235                1240                1245            
His Pro Leu Gln Ser Thr Thr Pro Asp Phe Trp Arg Leu Val Tyr Asp
    1250                1255                1260                
Tyr Gly Cys Thr Ser Ile Val Met Leu Asn Gln Leu Asn Gln Ser Asn
1265                1270                1275                1280
Ser Ala Trp Pro Cys Leu Gln Tyr Trp Pro Glu Pro Gly Arg Gln Gln
                1285                1290                1295    
Tyr Gly Leu Met Glu Val Glu Phe Met Ser Gly Thr Ala Asp Glu Asp
            1300                1305                1310        
Leu Val Ala Arg Val Phe Arg Val Gln Asn Ile Ser Arg Leu Gln Glu
        1315                1320                1325            
Gly His Leu Leu Val Arg His Phe Gln Phe Leu Arg Trp Ser Ala Tyr
    1330                1335                1340                
Arg Asp Thr Pro Asp Ser Glu Lys Ala Phe Leu His Leu Leu Ala Glu
1345                1350                1355                1360
Val Asp Lys Trp Gln Ala Glu Ser Gly Asp Gly Arg Thr Ile Val His
                1365                1370                1375    
Cys Leu Asn Gly Gly Gly Arg Arg Gly Thr Ser Cys Ala Leu Arg Thr
            1380                1385                1390        
Val Leu Glu Met Ile Arg Cys His Asn Leu Val Asp Val Ser Phe Ala
        1395                1400                1405            
Ala Lys Thr Leu Arg Asn Tyr Lys Pro Asn Met Val Glu Thr Met Asp
    1410                1415                1420                
Gln Tyr His Phe Cys Tyr Asp Val Ala Leu Glu Tyr Leu Glu Ala Gly
1425                1430                1435                1440
Val Arg
        


<210> 806
<211> 445
<212> PRT
<213> Homo sapiens

<400> 806
Met Arg Glu Ile Val His Ile Gln Ala Gly Gln Cys Gly Asn Gln Ile
 1               5                  10                  15      
Gly Ala Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro
            20                  25                  30          
Thr Gly Ser Tyr His Gly Asp Ser Asp Leu Gln Leu Glu Arg Ile Asn
        35                  40                  45              
Val Tyr Tyr Asn Glu Ala Ala Gly Asn Lys Tyr Val Pro Arg Ala Ile
    50                  55                  60                  
Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Pro
65                  70                  75                  80  
Phe Gly Gln Ile Phe Arg Pro Asp Asn Phe Val Phe Gly Gln Ser Gly
                85                  90                  95      
Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu
            100                 105                 110         
Val Asp Ser Val Leu Asp Val Val Arg Lys Glu Ser Glu Ser Cys Asp
        115                 120                 125             
Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly
    130                 135                 140                 
Ser Gly Met Gly Thr Leu Leu Ile Ser Lys Ile Arg Glu Glu Tyr Pro
145                 150                 155                 160 
Asp Arg Ile Met Asn Thr Phe Ser Val Met Pro Ser Pro Lys Val Ser
                165                 170                 175     
Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Val His Gln Leu
            180                 185                 190         
Val Glu Asn Thr Asp Glu Thr Tyr Cys Ile Asp Asn Glu Ala Leu Tyr
        195                 200                 205             
Asp Ile Cys Phe Arg Thr Leu Lys Leu Thr Thr Pro Thr Tyr Gly Asp
    210                 215                 220                 
Leu Asn His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Cys Leu
225                 230                 235                 240 
Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn
                245                 250                 255     
Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro
            260                 265                 270         
Leu Thr Ser Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Pro Glu
        275                 280                 285             
Leu Thr Gln Gln Met Phe Asp Ser Lys Asn Met Met Ala Ala Cys Asp
    290                 295                 300                 
Pro Arg His Gly Arg Tyr Leu Thr Val Ala Ala Ile Phe Arg Gly Arg
305                 310                 315                 320 
Met Ser Met Lys Glu Val Asp Glu Gln Met Leu Asn Val Gln Asn Lys
                325                 330                 335     
Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Thr Ala
            340                 345                 350         
Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ser Ala Thr Phe Ile
        355                 360                 365             
Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln
    370                 375                 380                 
Phe Thr Thr Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly
385                 390                 395                 400 
Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn
                405                 410                 415     
Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Asp Glu
            420                 425                 430         
Gln Gly Glu Phe Glu Glu Glu Glu Gly Glu Asp Glu Ala
        435                 440                 445 


<210> 807
<211> 259
<212> PRT
<213> Homo sapiens

<400> 807
Met Asp Glu Phe Phe Glu Gln Val Glu Glu Ile Arg Gly Phe Ile Asp
 1               5                  10                  15      
Lys Ile Ala Glu Asn Val Glu Glu Val Lys Arg Lys His Ser Ala Ile
            20                  25                  30          
Leu Ala Ser Pro Asn Pro Asp Glu Lys Thr Lys Val Glu Leu Glu Glu
        35                  40                  45              
Leu Met Ser Asp Ile Lys Lys Thr Ala Asn Lys Val Arg Ser Lys Leu
    50                  55                  60                  
Lys Ser Ile Glu Gln Ser Ile Glu Gln Glu Glu Gly Leu Asn Arg Ser
65                  70                  75                  80  
Ser Ala Asp Leu Arg Ile Arg Lys Thr Gln His Ser Thr Leu Ser Arg
                85                  90                  95      
Lys Phe Val Glu Val Met Ser Glu Tyr Asn Ala Thr Gln Ser Val Tyr
            100                 105                 110         
Arg Glu Arg Cys Lys Gly Arg Ile Gln Arg Gln Leu Glu Ile Thr Gly
        115                 120                 125             
Arg Thr Thr Thr Ser Glu Glu Leu Glu Asp Met Leu Glu Ser Gly Asn
    130                 135                 140                 
Pro Ala Ile Phe Ala Ser Gly Ile Ile Met Asp Ser Ser Ile Ser Lys
145                 150                 155                 160 
Gln Ala Leu Ser Glu Ile Glu Thr Arg His Ser Glu Ile Ile Lys Leu
                165                 170                 175     
Glu Asn Ser Ile Arg Glu Leu His Asp Met Phe Met Asp Met Ala Met
            180                 185                 190         
Leu Val Glu Ser Gln Gly Glu Met Ile Asp Arg Ile Glu Tyr Asn Val
        195                 200                 205             
Glu His Ala Val Asp Tyr Val Glu Arg Ala Val Ser Asp Thr Lys Lys
    210                 215                 220                 
Ala Val Lys Tyr Gln Ser Lys Ala Arg Arg Lys Lys Ile Met Ile Ile
225                 230                 235                 240 
Ile Cys Cys Val Ile Leu Gly Ile Val Ile Ala Ser Thr Val Gly Gly
                245                 250                 255     
Ile Phe Ala
            


<210> 808
<211> 530
<212> PRT
<213> Homo sapiens

<400> 808
Met Ala Arg Ala Gly Trp Thr Ser Pro Val Pro Leu Cys Val Cys Leu
 1               5                  10                  15      
Leu Leu Thr Cys Gly Phe Ala Glu Ala Gly Lys Leu Leu Val Val Pro
            20                  25                  30          
Met Asp Gly Ser His Trp Phe Thr Met Gln Ser Val Val Glu Lys Leu
        35                  40                  45              
Ile Leu Arg Gly His Glu Val Val Val Val Met Pro Glu Val Ser Trp
    50                  55                  60                  
Gln Leu Glu Arg Ser Leu Asn Cys Thr Val Lys Thr Tyr Ser Thr Ser
65                  70                  75                  80  
Tyr Thr Leu Glu Asp Gln Asn Arg Glu Phe Met Val Phe Ala His Ala
                85                  90                  95      
Gln Trp Lys Ala Gln Ala Gln Ser Ile Phe Ser Leu Leu Met Ser Ser
            100                 105                 110         
Ser Ser Gly Phe Leu Asp Leu Phe Phe Ser His Cys Arg Ser Leu Phe
        115                 120                 125             
Asn Asp Arg Lys Leu Val Glu Tyr Leu Lys Glu Ser Ser Phe Asp Ala
    130                 135                 140                 
Val Phe Leu Asp Pro Phe Asp Thr Cys Gly Leu Ile Val Ala Lys Tyr
145                 150                 155                 160 
Phe Ser Leu Pro Ser Val Val Phe Thr Arg Gly Ile Phe Cys His His
                165                 170                 175     
Leu Glu Glu Gly Ala Gln Cys Pro Ala Pro Leu Ser Tyr Val Pro Asn
            180                 185                 190         
Asp Leu Leu Gly Phe Ser Asp Ala Met Thr Phe Lys Glu Arg Val Trp
        195                 200                 205             
Asn His Ile Val His Leu Glu Asp His Leu Phe Cys Gln Tyr Leu Phe
    210                 215                 220                 
Arg Asn Ala Leu Glu Ile Ala Ser Glu Ile Leu Gln Thr Pro Val Thr
225                 230                 235                 240 
Ala Tyr Asp Leu Tyr Ser His Thr Ser Ile Trp Leu Leu Arg Thr Asp
                245                 250                 255     
Phe Val Leu Asp Tyr Pro Lys Pro Val Met Pro Asn Met Ile Phe Ile
            260                 265                 270         
Gly Gly Ile Asn Cys His Gln Gly Lys Pro Leu Pro Met Glu Ile Glu
        275                 280                 285             
Ala Tyr Ile Asn Ala Ser Gly Glu His Gly Ile Val Val Phe Ser Leu
    290                 295                 300                 
Gly Ser Met Val Ser Glu Ile Pro Glu Lys Lys Ala Met Ala Ile Ala
305                 310                 315                 320 
Asp Ala Leu Gly Lys Ile Pro Gln Thr Val Leu Trp Arg Tyr Thr Gly
                325                 330                 335     
Thr Arg Pro Ser Asn Leu Ala Asn Asn Thr Ile Leu Val Lys Trp Leu
            340                 345                 350         
Pro Gln Asn Asp Leu Leu Gly His Pro Met Thr Arg Ala Phe Ile Thr
        355                 360                 365             
His Ala Gly Ser His Gly Val Tyr Glu Ser Ile Cys Asn Gly Val Pro
    370                 375                 380                 
Met Val Met Met Pro Leu Phe Gly Asp Gln Met Asp Asn Ala Lys Arg
385                 390                 395                 400 
Met Glu Thr Lys Gly Ala Gly Val Thr Leu Asn Val Leu Glu Met Thr
                405                 410                 415     
Ser Glu Asp Leu Glu Asn Ala Leu Lys Ala Val Ile Asn Asp Lys Ser
            420                 425                 430         
Tyr Lys Glu Asn Ile Met Arg Leu Ser Ser Leu His Lys Asp Arg Pro
        435                 440                 445             
Val Glu Pro Leu Asp Leu Ala Val Phe Trp Val Glu Phe Val Met Arg
    450                 455                 460                 
His Lys Gly Ala Pro His Leu Arg Pro Ala Ala His Asp Leu Thr Trp
465                 470                 475                 480 
Tyr Gln Tyr His Ser Leu Asp Val Ile Gly Phe Leu Leu Ala Val Val
                485                 490                 495     
Leu Thr Val Ala Phe Ile Thr Phe Lys Cys Cys Ala Tyr Gly Tyr Arg
            500                 505                 510         
Lys Cys Leu Gly Lys Lys Gly Arg Val Lys Lys Ala His Lys Ser Lys
        515                 520                 525             
Thr His
    530 


<210> 809
<211> 3027
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 2862
<223> Xaa = Any Amino Acid

<400> 809
Met Asn Leu His Gln Val Leu Thr Gly Ala Val Asn Pro Gly Asp His
 1               5                  10                  15      
Cys Phe Ser Val Gly Ser Ile Gly Asp Gln Arg Phe Thr Ala Tyr Ala
            20                  25                  30          
Ser Gly Cys Asp Ile Val Ile Leu Gly Ser Asp Phe Glu Arg Leu Gln
        35                  40                  45              
Ile Ile Pro Gly Ala Lys His Gly Asn Ile Gln Val Gly Cys Val Asp
    50                  55                  60                  
Cys Ser Met Gln Gln Gly Lys Ile Ala Ala Ser Tyr Gly Asn Val Ile
65                  70                  75                  80  
Ser Ile Phe Glu Pro Val Asn Leu Pro Lys Gln Lys Lys Asn Leu Glu
                85                  90                  95      
Leu Tyr Ser Gln Trp Gln Lys Ser Gly Gln Phe Phe Leu Glu Ser Ile
            100                 105                 110         
Ala His Asn Ile Thr Trp Asp Pro Thr Gly Ser Arg Leu Leu Thr Gly
        115                 120                 125             
Ser Ser Tyr Leu Gln Leu Trp Ser Asn Thr Asn Leu Glu Lys Pro Thr
    130                 135                 140                 
Glu Asp Glu Asn Leu Asn Lys Thr Asp Leu Asn Phe Gly Asp Trp Lys
145                 150                 155                 160 
Cys Ile Trp His Cys Lys Thr Ala Ser Gln Val His Leu Met Lys Phe
                165                 170                 175     
Ser Pro Asp Gly Glu Phe Phe Ala Thr Ala Gly Lys Asp Asp Cys Leu
            180                 185                 190         
Leu Lys Val Trp Tyr Asn Val Glu Asn Trp Arg Thr Ala Val Thr Ser
        195                 200                 205             
Pro Asp Gly Ser Ser Glu Lys Gln Ser Gln Gly Glu Ile Asp Phe Ser
    210                 215                 220                 
Phe Val Tyr Leu Ala His Pro Arg Ala Val Asn Gly Phe Ser Trp Arg
225                 230                 235                 240 
Lys Thr Ser Lys Tyr Met Pro Arg Ala Ser Val Cys Asn Val Leu Leu
                245                 250                 255     
Thr Cys Cys Lys Asp Asn Val Cys Arg Leu Trp Val Glu Thr Phe Leu
            260                 265                 270         
Pro Asn Asp Cys Leu Leu Tyr Gly Gly Asp Cys Ser His Trp Thr Glu
        275                 280                 285             
Ser Ile Asn Leu Thr Asn Asn Phe Lys Arg Asn Ala Ser Ser Lys Glu
    290                 295                 300                 
Arg Val Gln Asn Ala Leu Glu Val Asn Leu Arg His Phe Arg Arg Gly
305                 310                 315                 320 
Arg Arg Arg Ser Leu Ala Leu Val Ala His Thr Gly Tyr Leu Pro His
                325                 330                 335     
Gln Gln Asp Pro His His Val His Arg Asn Thr Pro Leu His Ala Asn
            340                 345                 350         
Ala Leu Cys His Phe His Ile Ala Ala Ser Ile Asn Pro Ala Thr Asp
        355                 360                 365             
Ile Pro Leu Leu Pro Ser Ile Thr Ser Leu Ser Leu Asn Glu Asn Glu
    370                 375                 380                 
Glu Lys Thr Gly Pro Phe Val Val His Trp Leu Asn Asn Lys Glu Leu
385                 390                 395                 400 
His Phe Thr Leu Ser Met Glu Val Phe Leu Gln Gln Leu Arg Lys Ser
                405                 410                 415     
Phe Glu Gln Pro Ser Ser Glu Ala Ser Val Glu Asp Ser Asn Gln Ala
            420                 425                 430         
Asp Val Lys Ser Asp Glu Glu Thr Asp Asp Gly Val Asp Asp Leu Lys
        435                 440                 445             
Ile Asn Pro Glu Lys Lys Glu Leu Gly Cys Asp Lys Met Val Pro Asn
    450                 455                 460                 
Ser Ser Phe Thr Ser Leu Ser Ser Ala Ala Ile Asp His Gln Ile Glu
465                 470                 475                 480 
Val Leu Leu Ser Glu Trp Ser Lys Asn Ala Asp Met Leu Phe Ser Ile
                485                 490                 495     
His Pro Met Asp Gly Ser Leu Leu Val Trp His Val Asp Trp Leu Asp
            500                 505                 510         
Glu Tyr Gln Pro Gly Met Phe Arg Gln Val Gln Val Ser Phe Val Ser
        515                 520                 525             
Arg Ile Pro Val Ala Phe Pro Thr Gly Asp Ala Asn Ser Leu Cys Lys
    530                 535                 540                 
Ser Ile Met Met Tyr Ala Cys Thr Lys Asn Val Asp Leu Ala Ile Gln
545                 550                 555                 560 
Gln Gly Lys Gln Lys Pro Ser Gly Leu Thr Arg Ser Thr Ser Met Leu
                565                 570                 575     
Ile Ser Ser Gly His Asn Lys Ser Ser Asn Ser Leu Lys Leu Ser Ile
            580                 585                 590         
Phe Thr Pro Asn Val Met Met Ile Ser Lys His Ala Asp Gly Ser Leu
        595                 600                 605             
Asn Gln Trp Leu Val Ser Phe Ala Glu Glu Ser Ala Phe Ser Thr Val
    610                 615                 620                 
Leu Ser Ile Ser His Lys Ser Arg Tyr Cys Gly His Arg Phe His Leu
625                 630                 635                 640 
Asn Asp Leu Ala Cys His Ser Val Leu Pro Leu Leu Leu Thr Thr Ser
                645                 650                 655     
His His Asn Ala Leu Arg Thr Pro Asp Val Asp Asn Pro Glu Gln Pro
            660                 665                 670         
Phe Asp Ala Leu Asn Ile Glu Glu Cys Ser Leu Thr Gln Gln Asn Lys
        675                 680                 685             
Ser Thr Val Asp Val Ala Phe Gln Asp Pro Ser Ala Val Tyr Ser Glu
    690                 695                 700                 
Leu Ile Leu Trp Arg Val Asp Pro Val Gly Pro Leu Ser Phe Ser Gly
705                 710                 715                 720 
Gly Val Ser Glu Leu Ala Arg Ile Asn Ser Leu His Val Ser Ala Phe
                725                 730                 735     
Ser Asn Val Ala Trp Leu Pro Thr Leu Ile Pro Ser Tyr Cys Leu Gly
            740                 745                 750         
Ala Tyr Cys Asn Ser Pro Ser Ala Cys Phe Val Ala Ser Asp Gly Gln
        755                 760                 765             
Tyr Leu Arg Leu Tyr Glu Ala Val Ile Asp Ala Lys Lys Leu Leu Ser
    770                 775                 780                 
Glu Leu Ser Asn Pro Glu Ile Ser Lys Tyr Val Gly Glu Val Phe Asn
785                 790                 795                 800 
Ile Val Ser Gln Gln Ser Thr Ala Arg Pro Gly Cys Ile Ile Ala Leu
                805                 810                 815     
Asp Pro Ile Thr Lys Leu His Gly Arg Lys Thr Gln Leu Leu His Val
            820                 825                 830         
Phe Glu Glu Asp Phe Ile Leu Asn Asn Leu Glu Lys Lys Ser Leu Gly
        835                 840                 845             
Lys Asp Ser Ile Leu Ser Asn Ala Gly Ser Ser Pro Asn Gly Phe Ser
    850                 855                 860                 
Glu Lys Phe Tyr Leu Ile Val Ile Glu Cys Thr Gln Asp Asn Arg Ser
865                 870                 875                 880 
Leu Leu His Met Trp Asn Leu His Leu Lys Ser Ile Pro Val Ser Leu
                885                 890                 895     
Asp Glu Lys Val Asp Thr Lys Leu Ser Glu Ala Val Trp Gln Pro Glu
            900                 905                 910         
Glu His Tyr Ser Ser Ser Pro Glu Lys Ile Leu Ser Pro Phe Ser Gln
        915                 920                 925             
Lys Tyr Gln Ala Cys Arg Ala Asn Leu Gln Ser Thr Ser Arg Leu Thr
    930                 935                 940                 
Leu Phe Ser Glu Met Val Tyr Ser Gln Glu Leu His Leu Pro Glu Gly
945                 950                 955                 960 
Val Glu Ile Ile Ser Ile Lys Pro Ser Ala Gly His Leu Ser Ser Ser
                965                 970                 975     
Ser Ile Tyr Pro Ala Cys Ser Ala Pro Tyr Leu Leu Ala Thr Ser Cys
            980                 985                 990         
Ser Asp Glu Lys Val Arg Phe Trp Arg Cys Arg Val Thr Asp Gly Glu
        995                 1000                1005            
Ser Ala Thr Ser Lys Asn Gly Lys Ile Asp Leu Ala Tyr Ile Trp Glu
    1010                1015                1020                
Glu Trp Pro Leu Leu Ile Glu Asp Gly Leu Gln Ser Asn Ser Ser Ile
1025                1030                1035                1040
Thr Val Pro Gly Arg Pro Val Glu Val Ser Cys Ala His Thr Asn Arg
                1045                1050                1055    
Leu Ala Val Ala Tyr Lys Gln Pro Ala Ser Asn Ser Arg Ser Ser Gln
            1060                1065                1070        
Asp Phe Val Met His Val Ser Ile Phe Glu Cys Glu Ser Thr Gly Gly
        1075                1080                1085            
Ser Cys Trp Val Leu Glu Gln Thr Ile His Leu Asp Glu Leu Ser Thr
    1090                1095                1100                
Val Leu Asp Ser Gly Ile Ser Val Asp Ser Asn Leu Val Ala Tyr Asn
1105                1110                1115                1120
Lys Gln Asp Met Tyr Leu Ser Ser Lys Glu Asn Ile Thr Ser Asn Thr
                1125                1130                1135    
Lys His Leu Val His Leu Asp Trp Met Ser Arg Glu Asp Gly Ser His
            1140                1145                1150        
Ile Leu Thr Val Gly Ile Gly Ser Lys Leu Phe Met Tyr Gly Pro Leu
        1155                1160                1165            
Ala Gly Lys Val Gln Asp Gln Thr Gly Lys Glu Thr Leu Ala Phe Pro
    1170                1175                1180                
Leu Trp Glu Ser Thr Lys Val Val Pro Leu Ser Lys Phe Val Leu Leu
1185                1190                1195                1200
Arg Ser Val Asp Leu Val Ser Ser Val Asp Gly Ser Pro Pro Phe Pro
                1205                1210                1215    
Val Ser Leu Ser Trp Val Arg Asp Gly Ile Leu Val Val Gly Met Asp
            1220                1225                1230        
Cys Glu Met His Val Tyr Cys Gln Trp Gln Pro Ser Ser Lys Gln Glu
        1235                1240                1245            
Pro Val Ile Thr Asp Ser Tyr Ser Gly Ser Thr Pro Ser Ile Thr Ser
    1250                1255                1260                
Leu Ile Lys Gln Ser Asn Ser Ser Ser Gly Leu His Pro Pro Lys Lys
1265                1270                1275                1280
Thr Leu Thr Arg Ser Met Thr Ser Leu Ala Gln Lys Ile Cys Gly Lys
                1285                1290                1295    
Lys Thr Ala Phe Asp Pro Ser Val Asp Met Glu Asp Ser Gly Leu Phe
            1300                1305                1310        
Glu Ala Ala His Val Leu Ser Pro Thr Leu Pro Gln Tyr His Pro Leu
        1315                1320                1325            
Gln Leu Leu Glu Leu Met Asp Leu Gly Lys Val Arg Arg Ala Lys Ala
    1330                1335                1340                
Ile Leu Ser His Leu Val Lys Cys Ile Ala Gly Glu Val Val Ala Leu
1345                1350                1355                1360
Asn Glu Ala Glu Ser Asn His Glu Arg Arg Leu Arg Ser Leu Thr Ile
                1365                1370                1375    
Ser Ala Ser Gly Ser Thr Thr Arg Asp Pro Gln Ala Phe Asn Lys Ala
            1380                1385                1390        
Glu Asn Thr Asp Tyr Thr Glu Ile Asp Ser Val Pro Pro Leu Pro Leu
        1395                1400                1405            
Tyr Ala Leu Leu Ala Ala Asp Asp Asp Ser Cys Tyr Ser Ser Leu Glu
    1410                1415                1420                
Lys Ser Ser Asn Glu Ser Thr Leu Ser Lys Ser Asn Gln Leu Ser Lys
1425                1430                1435                1440
Glu Ser Tyr Asp Glu Leu Phe Gln Thr Gln Leu Leu Met Thr Asp Thr
                1445                1450                1455    
His Met Leu Glu Thr Asp Glu Glu Asn Thr Lys Pro Arg Val Ile Asp
            1460                1465                1470        
Leu Ser Gln Tyr Ser Pro Thr Tyr Phe Gly Pro Glu His Ala Gln Val
        1475                1480                1485            
Leu Ser Gly His Leu Leu His Ser Ser Leu Pro Gly Leu Ser Arg Met
    1490                1495                1500                
Glu Gln Met Ser Leu Met Ala Leu Ala Asp Thr Ile Ala Thr Thr Ser
1505                1510                1515                1520
Thr Asp Ile Gly Glu Ser Arg Asp Arg Ser Gln Gly Gly Glu Thr Leu
                1525                1530                1535    
Asp Glu Cys Gly Leu Lys Phe Leu Leu Ala Val Arg Leu His Thr Phe
            1540                1545                1550        
Leu Thr Thr Ser Leu Pro Ala Tyr Arg Ala Gln Leu Leu His Gln Gly
        1555                1560                1565            
Leu Ser Thr Ser His Phe Ala Trp Ala Phe His Ser Val Ala Glu Glu
    1570                1575                1580                
Glu Leu Leu Asn Met Leu Pro Ala Met Gln Lys Asp Asp Pro Thr Trp
1585                1590                1595                1600
Ser Glu Leu Arg Ala Met Gly Val Gly Trp Trp Val Arg Asn Thr Arg
                1605                1610                1615    
Ile Leu Arg Lys Cys Ile Glu Lys Val Ala Lys Ala Ala Phe Tyr Arg
            1620                1625                1630        
Lys Asn Asp Pro Leu Asp Ala Ala Ile Phe Tyr Leu Ala Met Lys Lys
        1635                1640                1645            
Lys Ala Val Ile Trp Gly Leu Tyr Arg Ala Glu Lys Asn Thr Arg Met
    1650                1655                1660                
Thr Gln Phe Phe Gly His Asn Phe Glu Asp Glu Arg Trp Arg Lys Ala
1665                1670                1675                1680
Ala Leu Lys Asn Ala Phe Ser Leu Leu Gly Lys Gln Arg Phe Glu His
                1685                1690                1695    
Ser Ala Ala Phe Phe Leu Leu Ala Gly Cys Leu Arg Asp Ala Ile Glu
            1700                1705                1710        
Val Cys Leu Glu Lys Leu Asn Asp Ile Gln Leu Ala Leu Val Ile Ala
        1715                1720                1725            
Arg Leu Tyr Glu Ser Glu Phe Asp Thr Ser Ala Ala Tyr Lys Ser Ile
    1730                1735                1740                
Leu Arg Lys Lys Val Leu Gly Ile Asp Ser Pro Val Ser Glu Leu Cys
1745                1750                1755                1760
Ser Leu Asn Ile Asn Met His His Asp Pro Phe Leu Arg Ser Met Ala
                1765                1770                1775    
Tyr Trp Ile Leu Glu Asp Tyr Ser Gly Ala Leu Glu Thr Leu Ile Lys
            1780                1785                1790        
Gln Pro Ile Arg Glu Asn Asp Asp Gln Val Leu Ser Ala Ser Asn Pro
        1795                1800                1805            
Thr Val Phe Asn Phe Tyr Asn Tyr Leu Arg Thr His Pro Leu Leu Leu
    1810                1815                1820                
Arg Arg His Phe Gly Ser Ser Asp Thr Phe Ser Thr His Met Ser Leu
1825                1830                1835                1840
Thr Gly Lys Ser Gly Leu Ala Gly Thr Ile Asn Leu Ser Glu Arg Arg
                1845                1850                1855    
Leu Phe Phe Thr Thr Ala Ser Ala His Leu Lys Ala Gly Cys Pro Met
            1860                1865                1870        
Leu Ala Leu Glu Val Leu Ser Lys Met Pro Lys Val Ile Lys Lys Thr
        1875                1880                1885            
Arg Pro Phe Tyr Arg Ala Ser Ser Phe Leu Asp Thr Ser Lys Asp Cys
    1890                1895                1900                
Ser Pro Ser Ser Pro Leu Lys Leu Asp Ala Arg Glu Asp Lys Ser Ser
1905                1910                1915                1920
Ala Val Asp Trp Ser Gln Ser Leu Ile Asn Gly Phe Gly Ser Ser Ser
                1925                1930                1935    
Glu Gly Ser Ser Glu Lys Gln Ser Asn Ser Thr Leu Ser Phe Asp Trp
            1940                1945                1950        
Ser Gln Pro Ser Val Val Phe Gln Asp Asp Ser Leu Glu Leu Lys Trp
        1955                1960                1965            
Asp Ser Asp Asn Asp Glu Glu Asn Glu Asp Val Pro Ile Ser Met Lys
    1970                1975                1980                
Glu Leu Lys Pro Leu Gln Arg Lys Thr Asp Lys Lys Leu Asp Asp Ile
1985                1990                1995                2000
Ser Ser Asn Tyr Thr Glu Ser Phe Ser Thr Leu Asp Glu Asn Asp Leu
                2005                2010                2015    
Leu Asn Pro Ser Glu Asp Ile Ile Ala Val Gln Leu Lys Phe Arg Ala
            2020                2025                2030        
Cys Leu Lys Ile Leu Thr Val Glu Leu Arg Thr Leu Ser Thr Gly Tyr
        2035                2040                2045            
Glu Ile Asp Gly Gly Lys Leu Arg Tyr Gln Leu Tyr His Trp Leu Glu
    2050                2055                2060                
Lys Glu Val Ile Ala Leu Gln Arg Thr Cys Asp Phe Cys Ser Asp Ala
2065                2070                2075                2080
Glu Glu Leu Gln Ser Ala Phe Gly Arg Asn Glu Asp Glu Phe Gly Leu
                2085                2090                2095    
Asn Glu Asp Ala Glu Asp Leu Pro His Gln Thr Lys Val Lys Gln Leu
            2100                2105                2110        
Arg Glu Asn Phe Gln Glu Lys Arg Gln Trp Leu Leu Lys Tyr Gln Ser
        2115                2120                2125            
Leu Leu Arg Met Phe Leu Ser Tyr Cys Ile Leu His Gly Ser His Gly
    2130                2135                2140                
Gly Gly Leu Ala Ser Val Arg Met Glu Leu Ile Leu Leu Leu Gln Glu
2145                2150                2155                2160
Ser Gln Gln Glu Thr Ser Glu Pro Leu Phe Ser Ser Leu Leu Ser Glu
                2165                2170                2175    
Gln Thr Ser Val Pro Leu Leu Phe Ala Cys Thr Ala Asn Ala Lys Thr
            2180                2185                2190        
Val Val Ala Asn Pro Leu Leu His Leu Ser Asn Leu Thr His Asp Ile
        2195                2200                2205            
Leu His Ala Ile Ile Asn Phe Asp Ser Pro Pro His Pro Asp Ile Gln
    2210                2215                2220                
Ser Asn Lys Val Tyr Val Met His Thr Leu Ala Ala Ser Leu Ser Ala
2225                2230                2235                2240
Cys Ile Tyr Gln Cys Leu Cys Gly Ser His Asn Tyr Ser Ser Phe Gln
                2245                2250                2255    
Thr Asn Gln Phe Thr Gly Met Val Tyr Gln Thr Val Leu Leu Pro His
            2260                2265                2270        
Arg Pro Ser Leu Lys Thr Gly Ser Leu Asp Glu Ala Leu Thr Pro Asn
        2275                2280                2285            
Thr Ser Pro Ala Gln Trp Pro Gly Ile Thr Cys Leu Ile Arg Leu Leu
    2290                2295                2300                
Asn Ser Ser Gly Glu Glu Ala Gln Ser Gly Leu Thr Val Leu Leu Cys
2305                2310                2315                2320
Glu Ile Leu Thr Ala Val Tyr Leu Ser Leu Phe Ile His Gly Leu Ala
                2325                2330                2335    
Thr His Ser Ser Asn Glu Leu Phe Arg Ile Val Ala His Pro Leu Asn
            2340                2345                2350        
Glu Lys Met Trp Ser Ala Val Phe Gly Gly Gly Ala His Val Pro Ser
        2355                2360                2365            
Lys Glu Gln Thr His Ser Lys Thr Leu Pro Val Ser Ser Leu Val Glu
    2370                2375                2380                
Glu Gly Glu Lys Gln Asn Lys Arg Phe Arg Pro Ser Lys Met Ser Cys
2385                2390                2395                2400
Arg Glu Ser Ala Pro Leu Thr Pro Ser Ser Ala Pro Val Ser Gln Glu
                2405                2410                2415    
Ser Leu Ala Val Lys Glu Lys Phe Ile Pro Pro Glu Leu Ser Ile Trp
            2420                2425                2430        
Asp Tyr Phe Ile Ala Lys Pro Phe Leu Pro Ser Ser Gln Ser Arg Ala
        2435                2440                2445            
Glu Tyr Asp Ser Glx Glu Ser Leu Gly Ser Asp Asp Asp Asp Asn Asp
    2450                2455                2460                
Asp Asp Asp Asp Val Leu Ala Ser Asp Phe His Leu Gln Glu His Ser
2465                2470                2475                2480
Asn Ser Asn Ser Tyr Ser Trp Ser Leu Met Arg Leu Ala Met Val Gln
                2485                2490                2495    
Leu Val Leu Asn Asn Leu Lys Thr Phe Tyr Pro Phe Ala Gly His Asp
            2500                2505                2510        
Leu Ala Glu Leu Pro Val Ser Ser Pro Leu Cys His Ala Val Leu Lys
        2515                2520                2525            
Thr Leu Gln Cys Trp Glu Gln Val Leu Leu Arg Arg Leu Glu Ile His
    2530                2535                2540                
Gly Gly Pro Pro Gln Asn Tyr Ile Ala Ser His Thr Ala Glu Glu Ser
2545                2550                2555                2560
Leu Ser Ala Gly Pro Ala Ile Leu Arg His Lys Ala Leu Leu Glu Pro
                2565                2570                2575    
Thr Asn Thr Pro Phe Lys Ser Lys His His Leu Ala Leu Ser Val Lys
            2580                2585                2590        
Arg Leu Trp Gln Tyr Leu Val Lys Gln Glu Glu Ile Gln Glu Thr Phe
        2595                2600                2605            
Ile Lys Asn Ile Phe Thr Lys Lys Arg Cys Leu Asn Glu Ile Glu Ala
    2610                2615                2620                
Asp Leu Gly Tyr Pro Gly Gly Lys Ala Arg Ile Ile His Lys Glu Ser
2625                2630                2635                2640
Asp Ile Ile Thr Ala Phe Ala Val Asn Lys Ala Asn Arg Asn Cys Ile
                2645                2650                2655    
Ala Ile Ala Ser Ser His Asp Val Gln Glu Leu Asp Val Ser Gly Ile
            2660                2665                2670        
Leu Ala Thr Gln Val Tyr Thr Trp Val Asp Asp Asp Ile Glu Val Glu
        2675                2680                2685            
Thr Lys Gly Ser Glu Asp Phe Leu Val Ile His Ala Arg Asp Asp Leu
    2690                2695                2700                
Thr Ala Val Gln Gly Thr Thr Pro Tyr Thr His Ser Asn Pro Gly Thr
2705                2710                2715                2720
Pro Ile Asn Met Pro Trp Leu Gly Ser Thr Gln Thr Gly Arg Gly Ala
                2725                2730                2735    
Ser Val Met Ile Lys Lys Ala Ile Asn Asn Val Arg Arg Met Thr Ser
            2740                2745                2750        
His Pro Thr Leu Pro Tyr Tyr Leu Thr Gly Ala Gln Asp Gly Ser Val
        2755                2760                2765            
Arg Met Phe Glu Trp Gly His Ser Gln Gln Ile Thr Cys Phe Arg Ser
    2770                2775                2780                
Gly Gly Asn Ser Arg Val Thr Arg Met Arg Phe Asn Tyr Gln Gly Asn
2785                2790                2795                2800
Lys Phe Gly Ile Val Asp Ala Asp Gly Tyr Leu Ser Leu Tyr Gln Thr
                2805                2810                2815    
Asn Trp Lys Cys Cys Pro Val Thr Gly Ser Met Pro Lys Pro Tyr Leu
            2820                2825                2830        
Thr Trp Gln Cys His Asn Lys Thr Ala Asn Asp Phe Val Phe Val Ser
        2835                2840                2845            
Ser Ser Ser Leu Ile Ala Thr Ala Gly Leu Ser Thr Asp Xaa Arg Asn
    2850                2855                2860                
Val Cys Leu Trp Asp Thr Leu Val Ala Pro Ala Asp Ser Leu Val His
2865                2870                2875                2880
Ala Phe Thr Cys His Asp Ser Gly Ala Thr Val Leu Ala Tyr Ala Pro
                2885                2890                2895    
Lys His Gln Leu Leu Ile Ser Gly Gly Arg Lys Gly Phe Thr Tyr Val
            2900                2905                2910        
Phe Asp Leu Cys Gln Arg Gln Gln Arg Gln Leu Phe Gln Ser His Asp
        2915                2920                2925            
Ser Pro Val Lys Ala Val Ala Val Asp Pro Thr Glu Glu Tyr Phe Val
    2930                2935                2940                
Thr Gly Ser Ala Glu Gly Asn Ile Lys Ile Trp Ser Leu Ser Thr Phe
2945                2950                2955                2960
Gly Leu Leu His Thr Phe Val Ser Glu His Ala Arg Gln Ser Ile Phe
                2965                2970                2975    
Arg Asn Ile Gly Thr Gly Val Met Gln Ile Glu Thr Gly Pro Ala Asn
            2980                2985                2990        
His Ile Phe Ser Cys Gly Ala Asp Gly Thr Met Lys Met Arg Ile Leu
        2995                3000                3005            
Pro Asp Gln Phe Ser Pro Leu Asn Glu Val Leu Lys Asn Asp Val Lys
    3010                3015                3020                
Phe Met Leu
3025        


<210> 810
<211> 186
<212> PRT
<213> Homo sapiens

<400> 810
Met Ala Val Ala Arg Ala Gly Val Leu Gly Val Gln Trp Leu Gln Arg
 1               5                  10                  15      
Ala Ser Arg Asn Val Met Pro Leu Gly Ala Arg Thr Ala Ser His Met
            20                  25                  30          
Thr Lys Asp Met Phe Pro Gly Pro Tyr Pro Arg Ile Pro Glu Glu Arg
        35                  40                  45              
Ala Ala Ala Ala Lys Lys Tyr Asn Met Arg Val Glu Asp Tyr Glu Pro
    50                  55                  60                  
Tyr Pro Asp Asp Gly Met Gly Tyr Gly Asp Tyr Pro Lys Leu Pro Asp
65                  70                  75                  80  
Arg Ser Gln His Glu Arg Asp Pro Trp Tyr Ser Trp Asp Gln Pro Gly
                85                  90                  95      
Leu Arg Leu Asn Trp Gly Glu Pro Met His Trp His Leu Asp Met Tyr
            100                 105                 110         
Asn Arg Asn Arg Val Asp Thr Ser Pro Thr Pro Val Ser Trp His Val
        115                 120                 125             
Met Cys Met Gln Leu Phe Gly Phe Leu Ala Phe Met Ile Phe Met Cys
    130                 135                 140                 
Trp Val Gly Asp Val Tyr Pro Val Tyr Gln Pro Val Gly Pro Lys Gln
145                 150                 155                 160 
Tyr Pro Tyr Asn Asn Leu Tyr Leu Glu Arg Gly Gly Asp Pro Ser Lys
                165                 170                 175     
Glu Pro Glu Arg Val Val His Asn Glu Ile
            180                 185     


<210> 811
<211> 1684
<212> PRT
<213> Homo sapiens

<400> 811
Met Ala Arg Asn Ala Ile Ser Asp Asp Glu Gly Thr Leu Ile Ala Ser
 1               5                  10                  15      
Ser Gln Thr Leu Ile Phe Phe Cys Val Lys Arg Arg Asn Asn Thr Arg
            20                  25                  30          
Asp His Glu Leu Glu Asp Asp Asp Gly Glu Pro Val His Gly Asp Pro
        35                  40                  45              
Ala Glu His Asp Glu Asn Asp Asp Glu Glu Asp Asp Asp Asp Gly Ile
    50                  55                  60                  
Ser Phe Phe Leu Asp Phe Asp Phe Ser Gln Leu Phe Asn Leu Asp Ser
65                  70                  75                  80  
Gly Tyr Phe Cys Ser Met Met Trp Asp Pro Tyr Ile Cys Phe Val Val
                85                  90                  95      
Gly Asn Glu Tyr Glu Asn Asp Gly Phe Ile Val Asn Asp Glu Asp Glu
            100                 105                 110         
Glu Glu Glu Glu Glu Glu Asp Glu Glu Arg Lys Asp Ser Asp Glu Glu
        115                 120                 125             
Arg Gln Lys Lys Lys Lys Lys Arg Lys Lys Lys Asp Glu Gly Leu Asp
    130                 135                 140                 
Glu Asp Asp Tyr Leu Leu Leu Gln Asp Asn Asn Val Lys Phe Lys Lys
145                 150                 155                 160 
Arg Gln Tyr Lys Arg Leu Lys Lys Ala Gln Arg Glu Gln Gly Asn Gly
                165                 170                 175     
Gln Gly Glu Ser Ser Asp Asp Glu Phe Asp Ser Arg Gly Gly Thr Arg
            180                 185                 190         
Arg Ser Ala Glu Asp Lys Ile Lys Asp Arg Leu Phe Asp Asp Val Asp
        195                 200                 205             
Val Asp Asp Pro Pro Asp Asp Val Gly Asp Glu Glu Asp Leu Val Val
    210                 215                 220                 
Glu Glu Asp Val Val Gly Ser Glu Asp Glu Met Ala Asp Phe Ile Val
225                 230                 235                 240 
Asp Glu Asp Asp Glu His Gly Pro Pro Lys Arg Gly Asn Ser Lys Lys
                245                 250                 255     
Lys Lys Tyr Arg Gln Gly Ser Asp Ile Thr Ala Met Arg Asp Ala Asn
            260                 265                 270         
Glu Ile Phe Gly Asp Val Asp Glu Leu Leu Thr Ile Arg Lys Lys Gly
        275                 280                 285             
Leu Ala Ser Asn Gln Arg Met Glu Arg Arg Leu Glu Asp Glu Phe Glu
    290                 295                 300                 
Pro Thr Val Leu Ser Glu Lys Tyr Met Thr Gly Asn Asp Asp Glu Ile
305                 310                 315                 320 
Arg Gln Leu Asp Ile Pro Glu Arg Met Gln Ile Ser Glu Glu Ser Thr
                325                 330                 335     
Gly Ser Pro Pro Val Asp Glu Ile Ser Ile Glu Glu Glu Ser Asn Trp
            340                 345                 350         
Ile Tyr Ala Gln Leu Ala Ser Gln Leu Arg Glu Ser Asp Gly Thr Phe
        355                 360                 365             
Asp Gly Arg Gly Phe Ser Val Asn Lys Asp Asp Ile Ala Lys Phe Leu
    370                 375                 380                 
Glu Leu His His Val Gln Lys Leu Glu Val Leu Asp Ser Phe Ser Pro
385                 390                 395                 400 
Met Tyr Arg Lys Glu Gln Cys Arg Ser Leu Leu Asp Thr Gly Asp Phe
                405                 410                 415     
Asp Gly Ala Asn Gln Gly Lys Lys Pro Glu Thr Lys Trp His Lys Val
            420                 425                 430         
Phe Trp Met Ile His Asp Leu Asp Lys Lys Trp Leu Leu Leu Arg Lys
        435                 440                 445             
Arg Lys Met Ala Leu His Gly Tyr Tyr Thr Lys Arg Tyr Glu Glu Glu
    450                 455                 460                 
Ser Arg Arg Val Tyr Asp Glu Thr Arg Leu Asn Leu Asn Gln Tyr Leu
465                 470                 475                 480 
Phe Glu Ser Val Ile Lys Ser Leu Lys Val Ala Glu Thr Glu Arg Glu
                485                 490                 495     
Val Asp Asp Val Asp Ser Lys Phe Asn Leu His Phe Pro Pro Gly Glu
            500                 505                 510         
Ile Gly Val Asp Glu Gly Gln Tyr Lys Arg Pro Lys Arg Lys Ser Gln
        515                 520                 525             
Tyr Ser Ile Cys Ser Lys Ala Gly Leu Trp Glu Val Ala Asn Lys Phe
    530                 535                 540                 
Gly Tyr Ser Ala Glu Gln Leu Gly Leu Ala Leu Ser Leu Glu Lys Leu
545                 550                 555                 560 
Val Asp Glu Leu Glu Asp Ala Lys Glu Thr Pro Glu Glu Met Ala Lys
                565                 570                 575     
Asn Phe Val Cys Ala Met Phe Glu Asn Ser Leu Ala Val Leu Lys Gly
            580                 585                 590         
Ala Arg His Met Ala Ala Val Glu Ile Ser Cys Glu Pro Ser Val Lys
        595                 600                 605             
Lys Tyr Val Arg Gly Ile Tyr Met Glu Asn Ala Val Val Ser Thr Ser
    610                 615                 620                 
Pro Thr Ala Asp Gly Asn Thr Val Ile Asp Ser Phe His Gln Phe Ser
625                 630                 635                 640 
Gly Ile Lys Trp Leu Arg Glu Lys Pro Leu Ser Lys Phe Glu Gly Ala
                645                 650                 655     
Gln Trp Leu Leu Ile Gln Lys Gly Glu Glu Glu Lys Leu Leu Gln Val
            660                 665                 670         
Thr Phe Lys Leu Pro Glu Asn Tyr Met Asn Arg Leu Ile Ser Asp Cys
        675                 680                 685             
Asn Glu His Tyr Leu Ser Val Gly Val Ser Lys Tyr Ala Gln Leu Trp
    690                 695                 700                 
Asn Glu Gln Arg Lys Leu Ile Leu Glu Asp Ala Leu His Ala Phe Leu
705                 710                 715                 720 
Leu Pro Ser Met Glu Lys Glu Ala Arg Ser Leu Leu Thr Ser Arg Ala
                725                 730                 735     
Lys Ser Arg Leu Leu Ser Glu Tyr Gly Gln Ala Leu Trp Asn Lys Val
            740                 745                 750         
Ser Ala Gly Pro Tyr Gln Lys Lys Glu Met Asp Ile Asn Leu Asp Glu
        755                 760                 765             
Glu Ala Ala Pro Arg Val Met Ala Cys Cys Trp Gly Pro Gly Lys Pro
    770                 775                 780                 
Pro Asn Thr Phe Val Met Leu Asp Ser Ser Gly Glu Val Leu Asp Val
785                 790                 795                 800 
Leu Tyr Ala Gly Ser Leu Thr Ser Arg Ser Gln Asn Val Asn Asp Gln
                805                 810                 815     
Gln Arg Lys Lys Ser Asp Gln Asp Arg Val Leu Lys Phe Met Met Asp
            820                 825                 830         
His Gln Pro His Val Val Ala Leu Gly Ala Val Asn Leu Ser Cys Thr
        835                 840                 845             
Arg Leu Lys Asp Asp Ile Tyr Glu Val Ile Phe Gln Met Val Glu Glu
    850                 855                 860                 
Lys Pro Arg Asp Val Gly His Gly Met Asp Asp Leu Ser Ile Val Tyr
865                 870                 875                 880 
Val Asp Glu Ser Leu Pro Arg Leu Tyr Glu Asn Ser Arg Ile Ser Gly
                885                 890                 895     
Glu Gln Leu Pro Gln Gln Ser Gly Asn Val Arg Arg Ala Val Ala Leu
            900                 905                 910         
Gly Arg Tyr Leu Gln Asn Pro Leu Ala Met Val Ala Thr Leu Cys Gly
        915                 920                 925             
Pro Gly Arg Glu Ile Leu Ser Trp Lys Leu His Pro Leu Glu Asn Phe
    930                 935                 940                 
Leu Gln Leu Asp Glu Lys Tyr Gly Met Val Glu Gln Val Met Val Asp
945                 950                 955                 960 
Ile Thr Asn Gln Phe Ile Ser Gly Leu Gly Pro Arg Lys Ala Ala Ser
                965                 970                 975     
Leu Gln Arg Ser Leu Val Arg Ala Gly Ser Ile Phe Val Arg Lys Asp
            980                 985                 990         
Leu Ile Met His Gly Leu Gly Lys Lys Val Phe Val Asn Ala Ala Gly
        995                 1000                1005            
Phe Leu Arg Ile Arg Arg Ser Gly Leu Ala Ala Ser Ser Ser Gln Phe
    1010                1015                1020                
Ile Asp Leu Leu Asp Asp Thr Arg Ile His Pro Glu Ser Tyr Ser Leu
1025                1030                1035                1040
Ala Gln Glu Leu Ala Lys Asp Ile Tyr Asp Glu Asp Val Arg Gly Asp
                1045                1050                1055    
Ser Asn Asp Asp Glu Asp Ala Ile Glu Met Ala Ile Glu His Val Arg
            1060                1065                1070        
Asp Arg Pro Ala Ser Leu Arg Lys Val Val Leu Asp Glu Tyr Leu Ala
        1075                1080                1085            
Ser Lys Lys Arg Glu Asn Lys Lys Glu Thr Tyr Ser Asn Ile Ile Arg
    1090                1095                1100                
Glu Leu Ser Cys Gly Phe Gln Asp Trp Arg Ile Pro Phe Lys Glu Pro
1105                1110                1115                1120
Ser Pro Asp Glu Glu Phe Tyr Met Ile Ser Gly Glu Thr Glu Asp Thr
                1125                1130                1135    
Ile Ala Glu Gly Arg Ile Val Gln Ala Ser Val Arg Arg Leu Gln Asn
            1140                1145                1150        
Gly Arg Ala Ile Cys Val Leu Asp Ser Gly Leu Thr Gly Met Leu Met
        1155                1160                1165            
Lys Glu Asp Phe Ser Asp Asp Gly Arg Asp Ile Val Asp Leu Ala Asp
    1170                1175                1180                
Gln Leu Lys Glu Gly Asp Ile Leu Thr Cys Lys Ile Lys Ser Ile Gln
1185                1190                1195                1200
Lys Gln Arg Tyr Gln Val Phe Leu Ile Cys Lys Glu Ser Glu Met Arg
                1205                1210                1215    
Asn Asn Arg His Gln His Asn Gln Asn Val Asp Ala Tyr Tyr His Glu
            1220                1225                1230        
Asp Arg Asn Ser Leu Gln Leu Val Lys Glu Lys Ala Arg Lys Glu Lys
        1235                1240                1245            
Glu Leu Val Arg Lys His Phe Lys Ser Arg Met Ile Val His Pro Arg
    1250                1255                1260                
Phe Gln Asn Ile Thr Ala Asp Gln Ala Thr Glu Tyr Leu Ser Asp Lys
1265                1270                1275                1280
Asp Phe Gly Glu Ser Ile Val Arg Pro Ser Ser Arg Gly Leu Asn Phe
                1285                1290                1295    
Leu Thr Leu Thr Leu Lys Ile Tyr Asp Gly Val Tyr Ala His Lys Glu
            1300                1305                1310        
Ile Ala Glu Gly Gly Lys Glu Asn Lys Asp Ile Thr Ser Leu Gln Cys
        1315                1320                1325            
Ile Gly Lys Thr Leu Thr Ile Gly Glu Asp Thr Phe Glu Asp Leu Asp
    1330                1335                1340                
Glu Val Met Asp Arg Tyr Val Asp Pro Leu Val Ser His Leu Lys Thr
1345                1350                1355                1360
Met Leu Asn Tyr Arg Lys Phe Arg Lys Gly Thr Lys Ser Glu Val Asp
                1365                1370                1375    
Asp Leu Leu Arg Ile Glu Lys Gly Glu Asn Pro Ser Arg Ile Val Tyr
            1380                1385                1390        
Cys Phe Gly Ile Ser His Glu His Pro Gly Thr Phe Ile Leu Ser Tyr
        1395                1400                1405            
Ile Arg Ser Thr Asn Pro His His Glu Tyr Ile Gly Leu Tyr Pro Lys
    1410                1415                1420                
Gly Phe Lys Phe Arg Lys Arg Met Phe Glu Asp Ile Asp Arg Leu Val
1425                1430                1435                1440
Ala Tyr Phe Gln Arg His Ile Asp Asp Pro Leu Gln Glu Ser Ala Pro
                1445                1450                1455    
Ser Ile Arg Ser Ile Ala Ala Lys Val Pro Met Arg Ser Pro Ala Asp
            1460                1465                1470        
His Gly Ser Ser Gly Gly Ser Gly Trp Gly Ser Ser Gln Ser Glu Gly
        1475                1480                1485            
Gly Trp Lys Gly Asn Ser Asp Arg Ser Gly Ser Gly Arg Gly Gly Glu
    1490                1495                1500                
Tyr Arg Asn Gly Gly Gly Arg Asp Gly His Pro Ser Gly Ala Pro Arg
1505                1510                1515                1520
Pro Tyr Gly Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Arg Asp Asp
                1525                1530                1535    
Met Asn Ser Asp Arg Gln Asp Gly Asn Gly Asp Trp Gly Asn Asn Asp
            1540                1545                1550        
Thr Gly Thr Ala Asp Gly Gly Trp Gly Asn Ser Gly Gly Gly Gly Trp
        1555                1560                1565            
Gly Ser Glu Ser Ala Gly Lys Lys Thr Gly Gly Gly Ser Thr Gly Gly
    1570                1575                1580                
Trp Gly Ser Glu Ser Gly Gly Asn Lys Ser Asp Gly Ala Gly Ser Trp
1585                1590                1595                1600
Gly Ser Gly Ser Gly Gly Gly Gly Ser Gly Gly Trp Gly Asn Asp Ser
                1605                1610                1615    
Gly Gly Lys Lys Ser Ser Glu Asp Gly Gly Phe Gly Ser Gly Ser Gly
            1620                1625                1630        
Gly Gly Gly Ser Asp Trp Gly Asn Glu Ser Gly Gly Lys Lys Ser Ser
        1635                1640                1645            
Ala Asp Gly Gly Trp Gly Ser Glu Ser Gly Gly Lys Lys Ser Asp Gly
    1650                1655                1660                
Glu Gly Gly Trp Gly Asn Glu Pro Ser Ser Arg Lys Ser Asp Gly Gly
1665                1670                1675                1680
Gly Gly Gly Trp
                


<210> 812
<211> 1082
<212> PRT
<213> Homo sapiens

<400> 812
Met Ile Lys Leu Lys Ser Leu Phe Arg Arg Gly Gln Gly Asn Ser Ser
 1               5                  10                  15      
Ser His Ser Ser Asn Ser Ser His Lys Gln Gln Gln Asn Ser Ser Asn
            20                  25                  30          
Asn Asn Arg Gln Lys Ser Gln Ser Ser Thr Ser Leu Asn Thr Ala His
        35                  40                  45              
Glu Gln Gln Gln Gln His Ser Ile Thr Ala Ala Thr Thr Lys Phe Tyr
    50                  55                  60                  
Ala His Gln Glu Thr Ala Ser Tyr Glu Arg Gly Val Asp Val Gly Asp
65                  70                  75                  80  
Glu Gly Ala Leu Leu Leu Thr Asn Gln Gln Gln Glu Gln Arg Arg Gln
                85                  90                  95      
Gln Gln Gln Leu Leu Gln Gln Pro Gln Ser Asn Thr Leu Pro Gln Lys
            100                 105                 110         
Lys Ser Lys Leu Lys Gly Gln Lys Gln Pro Lys Leu Leu Pro Val Gln
        115                 120                 125             
Gln Pro His Ser Asn Ala Pro Glu Pro His Asp Pro Gln Gln Pro Leu
    130                 135                 140                 
Met Thr Ser Leu Ala Ala Val Pro Gln Ala Ser Ala Thr Gly Ser Ser
145                 150                 155                 160 
Ser Asn Ser Asn Ile Asn Asn Asn Asn Ala Leu Ala Ala Leu Gln Asp
                165                 170                 175     
Gly Gly Ala Ala Ala Ala Ala Ala Ala Asp Phe Tyr Gln Gln Leu Ala
            180                 185                 190         
Ala Ala Ala Thr Ala Thr Ala Thr Ala Thr Ser Ala Asn Gly Ser Asn
        195                 200                 205             
Thr Ser Ala Asp Ser Pro Val Ser Ser Phe Pro Ala Ala Ala Ala Ala
    210                 215                 220                 
Val Ala Val Ala Ala Val Ala Ala Ser Ser Tyr Gln Gln Gln Gln Gln
225                 230                 235                 240 
Gln Gln Gln Leu Leu Asn Asn Glu Gln Gln Gln Gln Gln Leu Leu Glu
                245                 250                 255     
Ala Asn Asn Lys Met Gln Glu Leu His Lys Gln Met Glu Arg Phe Arg
            260                 265                 270         
Ser Glu Gln Met Gln Leu Glu Thr Arg Ile Thr Glu Leu Leu Pro Tyr
        275                 280                 285             
Gln Ser Glu Val Ala Lys Leu Lys Gly Asp Leu Val Lys Met Gln Ser
    290                 295                 300                 
Leu Gln Glu Lys Ser Gln Met Glu Ile Gly Asn Leu Lys Tyr Glu Asn
305                 310                 315                 320 
Glu Ser Leu Arg Asn Arg Leu Arg Asp Val Val Asn Ser Pro Leu Ser
                325                 330                 335     
Asp Ala Glu Lys His Gln Ile Ile Gln Asp Ser Gln Arg Leu His Ser
            340                 345                 350         
Ser Ala Pro Ala Ser Ile Ala Leu Pro Ser Thr His Asp Ala His Asp
        355                 360                 365             
Gly Thr Pro Cys Leu Thr Pro Asp Trp Asp Lys Gln Ser Ser Ser Ser
    370                 375                 380                 
Glu Ile Ser Val Ala Cys Leu Gln Asp Lys Ile Ile Gln Met Glu Glu
385                 390                 395                 400 
Thr His Tyr Ser Thr Asn Glu Glu Leu Gln Ala Thr Leu Gln Glu Leu
                405                 410                 415     
Ala Asp Leu Gln Thr Gln Leu Thr Asp Thr Gln Thr Glu Asn Glu Arg
            420                 425                 430         
Leu Ala Glu Glu Lys Asp Val Leu Phe Gln Ser Leu Cys Arg Gln Thr
        435                 440                 445             
Glu Lys Leu Asn Glu Ser Arg Thr Gln Ile Ser Thr Leu Gln Glu Leu
    450                 455                 460                 
Leu Leu Arg Asp Thr Lys Gln Pro Ala Pro Glu Val Ser Ala Ser Glu
465                 470                 475                 480 
Arg Glu Gln Lys Leu Leu Asp Leu Ile Lys Thr Ser Gln Glu Glu Arg
                485                 490                 495     
Glu Ala Val Leu Leu Lys Gln Glu Glu Leu Gly Ala Glu Leu Ala Glu
            500                 505                 510         
Met Lys Gln Ala Arg Glu Ala Gly Gln Leu Glu Leu Gln Arg Gln Arg
        515                 520                 525             
Glu Arg Ile Ala Leu Leu Asp Ser Gln Leu Asp Ala Ala Asn Ala Glu
    530                 535                 540                 
Arg Arg Gln Gly Glu Ala Gln Phe Ser Gln Ala Met Glu Glu Ile Ser
545                 550                 555                 560 
Gln Arg Ala Ile Glu Ile Ser Arg Leu Ser Thr Leu Leu Glu Asn Ala
                565                 570                 575     
Arg Ser Lys Ile Glu Glu Leu Glu Ala Asp Leu Ser Arg Gly Asp Lys
            580                 585                 590         
Thr Asp Leu Ser Glu Val Leu Asp Val Ala Arg Lys Glu Lys Asp Ala
        595                 600                 605             
Leu Glu Glu Arg Val Ala Glu Leu Gln Asp Gln Cys Ser Arg Ser Gln
    610                 615                 620                 
Ala Glu Leu Arg Arg Leu Arg Asp Gln Leu Ser Gly Leu Thr Glu Glu
625                 630                 635                 640 
Cys Lys Val Val Lys Asn Asn Ala Lys Cys Ala Val Ser His Leu Glu
                645                 650                 655     
Tyr Arg Leu Glu Gln Leu Gln Arg Asp Lys Asp Lys Ile Ala Gly Glu
            660                 665                 670         
Trp Gln Ala Leu Glu Glu Arg Val Ala Glu Leu Gln Val Gln Cys Lys
        675                 680                 685             
Cys His Gln Glu Asp Lys Ala Gln Leu Gln Ser Leu Leu Ala Glu Thr
    690                 695                 700                 
Gln Arg His Leu Gly Asp Val Gln Leu Lys Leu Gly Glu Ala Glu Cys
705                 710                 715                 720 
Arg Leu Asp Gln Glu Thr Gln Leu Arg Arg Lys Glu Ala Glu Glu Trp
                725                 730                 735     
Gln Gln Phe Gln Ala Asp Leu Leu Met Thr Val Arg Val Ala Asn Asp
            740                 745                 750         
Phe Lys Thr Glu Ala Leu Ser Ala Arg Glu Gln Leu Val Leu Asp Asn
        755                 760                 765             
Lys Thr Gln Lys Glu Lys Ile Arg Leu Leu Glu Gln Gln Leu Glu Lys
    770                 775                 780                 
Leu Thr Lys Gln Gln Met Gln Gln Ser Glu Thr Pro Gln Ser Val Leu
785                 790                 795                 800 
Ser Thr Val Gln Arg Glu Met Glu Met Ala Thr Arg Arg Ser Lys Leu
                805                 810                 815     
Ser Phe Ser Arg Gln Asp Ser Arg Leu Ser Val Lys Thr Leu Ile Glu
            820                 825                 830         
Ser Ile Glu Asn Asn Lys Ala Gln Gly Lys Ala Asp Glu Ser Glu Ser
        835                 840                 845             
His Tyr Ser Ser Thr Ser Ser Leu Asn Ser Gly Thr Pro Asp Leu Gly
    850                 855                 860                 
Thr Thr Pro Ile Ile Phe Pro Pro Ser Ser Asp Trp His Glu Ser Ile
865                 870                 875                 880 
Arg Leu Pro Val Leu Gln Ser Thr Asn Leu His Val Asn Val Gly Asn
                885                 890                 895     
Glu Ala Gly Ala Gly Gln Gly Thr Asn Thr Ser Ser Gly Ser Gly Gly
            900                 905                 910         
Asp Leu Ala Ser Thr Thr Lys Ala Thr Leu Pro Leu Arg Asp Gln Gln
        915                 920                 925             
Gln Leu Ala Ile Thr Ser Thr Gln Ser Gln Val Gln Asn Val Ser Gln
    930                 935                 940                 
Pro Ser Thr Pro Ala Thr Pro Ser Ser Ala Gly Ser Ser Ser Ser Gly
945                 950                 955                 960 
Gly Leu Pro Phe Gly Asn Val Ser Lys Ser Phe Ile Ser Gly Glu Arg
                965                 970                 975     
Lys Asp Pro Leu Asn Met Leu Ala Lys Asn Gly Gly Ser Lys Arg Asn
            980                 985                 990         
Ala Leu Leu Lys Trp Cys Gln Asn Lys Thr Val Gly Tyr Arg Asn Ile
        995                 1000                1005            
Asp Ile Thr Asn Phe Ser Ser Ser Trp Asn Asp Gly Leu Ala Phe Cys
    1010                1015                1020                
Ala Ile Leu His Ser Tyr Leu Pro Asp Arg Ile Pro Tyr Asp Gln Leu
1025                1030                1035                1040
Thr Pro Ala Asn Lys Arg Arg Asn Phe Ser Leu Ala Phe Ala Ala Ala
                1045                1050                1055    
Glu Ser Val Gly Ile Gly Thr Thr Leu Val Ser Phe His Gly Gln Gln
            1060                1065                1070        
Lys Leu Asn Leu Phe Ile Leu Ile Leu Ile
        1075                1080        


<210> 813
<211> 231
<212> PRT
<213> Homo sapiens

<400> 813
Val Val Gly Lys Ser Ala Asp Phe Val Val Glu Ala Ile Gly Thr Glu
 1               5                  10                  15      
Val Gly Thr Leu Gly Phe Ser Ile Glu Gly Pro Ser Gln Ala Lys Ile
            20                  25                  30          
Glu Cys Asp Asp Lys Gly Asp Gly Ser Cys Asp Val Arg Tyr Trp Pro
        35                  40                  45              
Thr Glu Pro Gly Glu Tyr Ala Val His Val Ile Cys Asp Asp Glu Asp
    50                  55                  60                  
Ile Arg Asp Ser Pro Phe Ile Ala His Ile Leu Pro Ala Pro Pro Asp
65                  70                  75                  80  
Cys Phe Pro Asp Lys Val Lys Ala Phe Gly Pro Gly Leu Glu Pro Thr
                85                  90                  95      
Gly Cys Ile Val Asp Lys Pro Ala Glu Phe Thr Ile Asp Ala Arg Ala
            100                 105                 110         
Ala Gly Lys Gly Asp Leu Lys Leu Tyr Ala Gln Asp Ala Asp Gly Cys
        115                 120                 125             
Pro Ile Asp Ile Lys Val Ile Pro Asn Gly Asn Gly Thr Phe Arg Cys
    130                 135                 140                 
Ser Tyr Val Pro Thr Lys Pro Ile Lys His Thr Ile Ile Ile Ser Trp
145                 150                 155                 160 
Gly Gly Val Asn Val Pro Lys Ser Pro Phe Arg Val Asn Val Gly Glu
                165                 170                 175     
Gly Ser His Pro Glu Arg Val Lys Val Tyr Gly Pro Gly Val Glu Lys
            180                 185                 190         
Thr Ala Ser Arg Pro Met Ser Pro Pro Thr Phe Thr Val Asp Cys Ser
        195                 200                 205             
Glu Ala Gly Gln Gly Asp Val Ser Ile Gly Ile Lys Cys Ala Pro Gly
    210                 215                 220                 
Val Val Gly Pro Ala Glu Ala
225                 230     


<210> 814
<211> 1641
<212> PRT
<213> Homo sapiens

<400> 814
Met Asp Asn Gln Gly His Lys Asn Leu Lys Thr Ser Gln Glu Gly Ser
 1               5                  10                  15      
Ser Asp Asp Arg Glu Arg Lys Gln Glu Arg Glu Thr Phe Ser Ser Ala
            20                  25                  30          
Glu Gly Thr Val Asp Lys Asp Thr Thr Ile Met Glu Leu Arg Asp Arg
        35                  40                  45              
Leu Pro Lys Lys Gln Gln Ala Ser Ala Ser Thr Asp Gly Val Asp Lys
    50                  55                  60                  
Leu Ser Gly Lys Glu Gln Ser Phe Thr Ser Leu Glu Val Arg Lys Val
65                  70                  75                  80  
Ala Glu Thr Lys Glu Lys Ser Lys His Leu Lys Thr Lys Thr Cys Lys
                85                  90                  95      
Lys Val Gln Asp Gly Leu Ser Asp Ile Ala Glu Lys Phe Leu Lys Lys
            100                 105                 110         
Asp Gln Ser Asp Glu Thr Ser Glu Asp Asp Lys Lys Gln Ser Lys Lys
        115                 120                 125             
Gly Thr Glu Glu Lys Lys Lys Pro Ser Asp Phe Lys Lys Lys Val Ile
    130                 135                 140                 
Lys Met Glu Gln Gln Tyr Glu Ser Ser Ser Asp Gly Thr Glu Lys Leu
145                 150                 155                 160 
Pro Glu Arg Glu Glu Ile Cys His Phe Pro Lys Gly Ile Lys Gln Ile
                165                 170                 175     
Lys Asn Gly Thr Thr Asp Gly Glu Lys Lys Ser Lys Lys Ile Arg Asp
            180                 185                 190         
Lys Thr Ser Lys Lys Lys Asp Glu Leu Ser Asp Tyr Ala Glu Lys Ser
        195                 200                 205             
Thr Gly Lys Gly Asp Ser Cys Asp Ser Ser Glu Asp Lys Lys Ser Lys
    210                 215                 220                 
Asn Gly Ala Tyr Gly Arg Glu Lys Lys Arg Cys Lys Leu Leu Gly Lys
225                 230                 235                 240 
Ser Ser Arg Lys Arg Gln Asp Cys Ser Ser Ser Asp Thr Glu Lys Tyr
                245                 250                 255     
Ser Met Lys Glu Asp Gly Cys Asn Ser Ser Asp Lys Arg Leu Lys Arg
            260                 265                 270         
Ile Glu Leu Arg Glu Arg Arg Asn Leu Ser Ser Lys Arg Asn Thr Lys
        275                 280                 285             
Glu Ile Gln Ser Gly Ser Ser Ser Ser Asp Ala Glu Glu Ser Ser Glu
    290                 295                 300                 
Asp Asn Lys Lys Lys Lys Gln Arg Thr Ser Ser Lys Lys Lys Ala Val
305                 310                 315                 320 
Ile Val Lys Glu Lys Lys Arg Asn Ser Leu Arg Thr Ser Thr Lys Arg
                325                 330                 335     
Lys Gln Ala Asp Ile Thr Ser Ser Ser Ser Ser Asp Ile Glu Asp Asp
            340                 345                 350         
Asp Gln Asn Ser Ile Gly Glu Gly Ser Ser Asp Glu Gln Lys Ile Lys
        355                 360                 365             
Pro Val Thr Glu Asn Leu Val Leu Ser Ser His Thr Gly Phe Cys Gln
    370                 375                 380                 
Ser Ser Gly Asp Glu Ala Leu Ser Lys Ser Val Pro Val Thr Val Asp
385                 390                 395                 400 
Asp Asp Asp Asp Asp Asn Asp Pro Glu Asn Arg Ile Ala Lys Lys Met
                405                 410                 415     
Leu Leu Glu Glu Ile Lys Ala Asn Leu Ser Ser Asp Glu Asp Gly Ser
            420                 425                 430         
Ser Asp Asp Glu Pro Glu Glu Gly Lys Lys Arg Thr Gly Lys Gln Asn
        435                 440                 445             
Glu Glu Asn Pro Gly Asp Glu Glu Ala Lys Asn Gln Val Asn Ser Glu
    450                 455                 460                 
Ser Asp Ser Asp Ser Glu Glu Ser Lys Lys Pro Arg Tyr Arg His Arg
465                 470                 475                 480 
Leu Leu Arg His Lys Leu Thr Val Ser Asp Gly Glu Ser Gly Glu Glu
                485                 490                 495     
Lys Lys Thr Lys Pro Lys Glu His Lys Glu Val Lys Gly Arg Asn Arg
            500                 505                 510         
Arg Lys Val Ser Ser Glu Asp Ser Glu Asp Ser Asp Phe Gln Glu Ser
        515                 520                 525             
Gly Val Ser Glu Glu Val Ser Glu Ser Glu Asp Glu Gln Arg Pro Arg
    530                 535                 540                 
Thr Arg Ser Ala Lys Lys Ala Glu Leu Glu Glu Asn Gln Arg Ser Tyr
545                 550                 555                 560 
Lys Gln Lys Lys Lys Arg Arg Arg Ile Lys Val Gln Glu Asp Ser Ser
                565                 570                 575     
Ser Glu Asn Lys Ser Asn Ser Glu Glu Glu Glu Glu Glu Lys Glu Glu
            580                 585                 590         
Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Asn
        595                 600                 605             
Asp Asp Ser Lys Ser Pro Gly Lys Gly Arg Lys Lys Ile Arg Lys Ile
    610                 615                 620                 
Leu Lys Asp Asp Lys Leu Arg Thr Glu Thr Gln Asn Ala Leu Lys Glu
625                 630                 635                 640 
Glu Glu Glu Arg Arg Lys Arg Ile Ala Glu Arg Glu Arg Glu Arg Glu
                645                 650                 655     
Lys Leu Arg Glu Val Ile Glu Ile Glu Asp Ala Ser Pro Thr Lys Cys
            660                 665                 670         
Pro Ile Thr Thr Lys Leu Val Leu Asp Glu Asp Glu Glu Thr Lys Glu
        675                 680                 685             
Pro Leu Val Gln Val His Arg Asn Met Val Ile Lys Leu Lys Pro His
    690                 695                 700                 
Gln Val Asp Gly Val Gln Phe Met Trp Asp Cys Cys Cys Glu Ser Val
705                 710                 715                 720 
Lys Lys Thr Lys Lys Ser Pro Gly Ser Gly Cys Ile Leu Ala His Cys
                725                 730                 735     
Met Gly Leu Gly Lys Thr Leu Gln Val Val Ser Phe Leu His Thr Val
            740                 745                 750         
Leu Leu Cys Asp Lys Leu Asp Phe Ser Thr Ala Leu Val Gly Leu Ser
        755                 760                 765             
Ser Ser Ile Leu Ala Phe Asn Trp Met Asn Glu Phe Glu Lys Trp Gln
    770                 775                 780                 
Glu Gly Leu Lys Asp Asp Glu Lys Leu Glu Val Ser Glu Leu Ala Thr
785                 790                 795                 800 
Val Lys Arg Pro Gln Glu Arg Ser Tyr Met Leu Gln Arg Trp Gln Glu
                805                 810                 815     
Asp Gly Gly Val Met Ile Ile Gly Tyr Glu Met Tyr Arg Asn Leu Ala
            820                 825                 830         
Gln Gly Arg Asn Val Lys Ser Arg Lys Leu Lys Glu Ile Phe Asn Lys
        835                 840                 845             
Ala Leu Val Asp Pro Gly Pro Asp Phe Val Val Cys Asp Glu Gly His
    850                 855                 860                 
Ile Leu Lys Asn Glu Ala Ser Ala Val Ser Lys Ala Met Asn Ser Ile
865                 870                 875                 880 
Arg Ser Arg Arg Arg Ile Ile Leu Thr Gly Thr Pro Leu Gln Asn Asn
                885                 890                 895     
Leu Ile Glu Tyr His Cys Met Val Asn Phe Ile Lys Glu Asn Leu Leu
            900                 905                 910         
Gly Ser Ile Lys Glu Phe Arg Asn Arg Phe Ile Asn Pro Ile Gln Asn
        915                 920                 925             
Gly Gln Cys Ala Asp Ser Thr Met Val Asp Val Arg Val Met Lys Lys
    930                 935                 940                 
Arg Ala His Ile Leu Tyr Glu Met Leu Ala Gly Cys Val Gln Arg Lys
945                 950                 955                 960 
Asp Tyr Thr Ala Leu Thr Lys Phe Leu Pro Pro Lys His Glu Tyr Val
                965                 970                 975     
Leu Ala Val Arg Met Thr Ser Ile Gln Cys Lys Leu Tyr Gln Tyr Tyr
            980                 985                 990         
Leu Asp His Leu Thr Gly Val Gly Asn Asn Ser Glu Gly Gly Arg Gly
        995                 1000                1005            
Lys Ala Gly Ala Lys Leu Phe Gln Asp Phe Gln Met Leu Ser Arg Ile
    1010                1015                1020                
Trp Thr His Pro Trp Cys Leu Gln Leu Asp Tyr Ile Ser Lys Glu Asn
1025                1030                1035                1040
Lys Gly Tyr Phe Asp Glu Asp Ser Met Asp Glu Phe Ile Ala Ser Asp
                1045                1050                1055    
Ser Asp Glu Thr Ser Met Ser Leu Ser Ser Asp Asp Tyr Thr Lys Lys
            1060                1065                1070        
Lys Lys Lys Gly Lys Lys Gly Lys Lys Asp Ser Ser Ser Ser Gly Ser
        1075                1080                1085            
Gly Ser Asp Asn Asp Val Glu Val Ile Lys Val Trp Asn Ser Arg Ser
    1090                1095                1100                
Arg Gly Gly Gly Glu Gly Asn Val Asp Glu Thr Gly Asn Asn Pro Ser
1105                1110                1115                1120
Val Ser Leu Lys Leu Glu Glu Ser Lys Ala Thr Ser Ser Ser Asn Pro
                1125                1130                1135    
Ser Ser Pro Ala Pro Asp Trp Tyr Lys Asp Phe Val Thr Asp Ala Asp
            1140                1145                1150        
Ala Glu Val Leu Glu His Ser Gly Lys Met Val Leu Leu Phe Glu Ile
        1155                1160                1165            
Leu Arg Met Ala Glu Glu Ile Gly Asp Lys Val Leu Val Phe Ser Gln
    1170                1175                1180                
Ser Leu Ile Ser Leu Asp Leu Ile Glu Asp Phe Leu Glu Leu Ala Ser
1185                1190                1195                1200
Arg Glu Lys Thr Glu Asp Lys Asp Lys Pro Leu Ile Tyr Lys Gly Glu
                1205                1210                1215    
Gly Lys Trp Leu Arg Asn Ile Asp Tyr Tyr Arg Leu Asp Gly Ser Thr
            1220                1225                1230        
Thr Ala Gln Ser Arg Lys Lys Trp Ala Glu Glu Phe Asn Asp Glu Thr
        1235                1240                1245            
Asn Val Arg Gly Arg Leu Phe Ile Ile Ser Thr Lys Ala Gly Ser Leu
    1250                1255                1260                
Gly Ile Asn Leu Val Ala Ala Asn Arg Val Ile Ile Phe Asp Ala Ser
1265                1270                1275                1280
Trp Asn Pro Ser Tyr Asp Ile Gln Ser Ile Phe Arg Val Tyr Arg Phe
                1285                1290                1295    
Gly Gln Thr Lys Pro Val Tyr Val Tyr Arg Phe Leu Ala Gln Gly Thr
            1300                1305                1310        
Met Glu Asp Lys Ile Tyr Asp Arg Gln Val Thr Lys Gln Ser Leu Ser
        1315                1320                1325            
Phe Arg Val Val Asp Gln Gln Gln Val Glu Arg His Phe Thr Met Asn
    1330                1335                1340                
Glu Leu Thr Glu Leu Tyr Thr Phe Glu Pro Asp Leu Leu Asp Asp Pro
1345                1350                1355                1360
Asn Ser Glu Lys Lys Lys Lys Arg Asp Thr Pro Met Leu Pro Lys Asp
                1365                1370                1375    
Thr Ile Leu Ala Glu Leu Leu Gln Ile His Lys Glu His Ile Val Gly
            1380                1385                1390        
Tyr His Glu His Asp Ser Leu Leu Thr Thr Lys Lys Lys Lys Arg Leu
        1395                1400                1405            
Thr Glu Glu Glu Arg Lys Ala Ala Trp Ala Glu Tyr Glu Gly Glu Lys
    1410                1415                1420                
Arg Val Leu Thr Met Arg Phe Asn Ile Pro Thr Gly Thr Asn Leu Pro
1425                1430                1435                1440
Pro Val Ser Phe Asn Ser Gln Thr Pro Tyr Ile Pro Phe Asn Leu Gly
                1445                1450                1455    
Ala Leu Ser Ala Met Ser Asn Gln Gln Leu Glu Asp Leu Ile Asn Gln
            1460                1465                1470        
Gly Arg Glu Lys Val Val Glu Ala Thr Asn Ser Val Thr Ala Val Arg
        1475                1480                1485            
Ile Gln Pro Leu Glu Asp Ile Ile Ser Ala Val Trp Lys Glu Asn Met
    1490                1495                1500                
Asn Leu Ser Glu Ala Gln Val Gln Ala Leu Ala Leu Ser Arg Gln Ala
1505                1510                1515                1520
Ser Gln Glu Leu Asp Val Lys Arg Arg Glu Ala Ile Tyr Asn Asp Val
                1525                1530                1535    
Leu Thr Lys Gln Gln Met Leu Ile Gln Leu Cys Ser Ala Asn Thr Tyr
            1540                1545                1550        
Glu Gln Lys Ala Pro Ala Ala Val Gln Ser Ala Ala Thr Ala Thr Asn
        1555                1560                1565            
Asp Leu Ser Thr Thr Thr Leu Gly His His Met Met Pro Lys Pro Arg
    1570                1575                1580                
Asn Leu Ile Met Asn Pro Ser Asn Tyr Gln Gln Ile Asp Met Arg Gly
1585                1590                1595                1600
Met Tyr Gln Pro Val Ala Gly Gly Met Gln Pro Pro Pro Leu Gln Arg
                1605                1610                1615    
Cys Thr Thr Pro Asn Glu Lys Gln Lys Ile Gln Asp Leu Pro Lys Gly
            1620                1625                1630        
Asn Gln Cys Asp Phe Ala Leu Lys Ala
        1635                1640    


<210> 815
<211> 1641
<212> PRT
<213> Homo sapiens

<400> 815
Met Asp Asn Gln Gly His Lys Asn Leu Lys Thr Ser Gln Glu Gly Ser
 1               5                  10                  15      
Ser Asp Asp Arg Glu Arg Lys Gln Glu Arg Glu Thr Phe Ser Ser Ala
            20                  25                  30          
Glu Gly Thr Val Asp Lys Asp Thr Thr Ile Met Glu Leu Arg Asp Arg
        35                  40                  45              
Leu Pro Lys Lys Gln Gln Ala Ser Ala Ser Thr Asp Gly Val Asp Lys
    50                  55                  60                  
Leu Ser Gly Lys Glu Gln Ser Phe Thr Ser Leu Glu Val Arg Lys Val
65                  70                  75                  80  
Ala Glu Thr Lys Glu Lys Ser Lys His Leu Lys Thr Lys Thr Cys Lys
                85                  90                  95      
Lys Val Gln Asp Gly Leu Ser Asp Ile Ala Glu Lys Phe Leu Lys Lys
            100                 105                 110         
Asp Gln Ser Asp Glu Thr Ser Glu Asp Asp Lys Lys Gln Ser Lys Lys
        115                 120                 125             
Gly Thr Glu Glu Lys Lys Lys Pro Ser Asp Phe Lys Lys Lys Val Ile
    130                 135                 140                 
Lys Met Glu Gln Gln Tyr Glu Ser Ser Ser Asp Gly Thr Glu Lys Leu
145                 150                 155                 160 
Pro Glu Arg Glu Glu Ile Cys His Phe Pro Lys Gly Ile Lys Gln Ile
                165                 170                 175     
Lys Asn Gly Thr Thr Asp Gly Glu Lys Lys Ser Lys Lys Ile Arg Asp
            180                 185                 190         
Lys Thr Ser Lys Lys Lys Asp Glu Leu Ser Asp Tyr Ala Glu Lys Ser
        195                 200                 205             
Thr Gly Lys Gly Asp Ser Cys Asp Ser Ser Glu Asp Lys Lys Ser Lys
    210                 215                 220                 
Asn Gly Ala Tyr Gly Arg Glu Lys Lys Arg Cys Lys Leu Leu Gly Lys
225                 230                 235                 240 
Ser Ser Arg Lys Arg Gln Asp Cys Ser Ser Ser Asp Thr Glu Lys Tyr
                245                 250                 255     
Ser Met Lys Glu Asp Gly Cys Asn Ser Ser Asp Lys Arg Leu Lys Arg
            260                 265                 270         
Ile Glu Leu Arg Glu Arg Arg Asn Leu Ser Ser Lys Arg Asn Thr Lys
        275                 280                 285             
Glu Ile Gln Ser Gly Ser Ser Ser Ser Asp Ala Glu Glu Ser Ser Glu
    290                 295                 300                 
Asp Asn Lys Lys Lys Lys Gln Arg Thr Ser Ser Lys Lys Lys Ala Val
305                 310                 315                 320 
Ile Val Lys Glu Lys Lys Arg Asn Ser Leu Arg Thr Ser Thr Lys Arg
                325                 330                 335     
Lys Gln Ala Asp Ile Thr Ser Ser Ser Ser Ser Asp Ile Glu Asp Asp
            340                 345                 350         
Asp Gln Asn Ser Ile Gly Glu Gly Ser Ser Asp Glu Gln Lys Ile Lys
        355                 360                 365             
Pro Val Thr Glu Asn Leu Val Leu Ser Ser His Thr Gly Phe Cys Gln
    370                 375                 380                 
Ser Ser Gly Asp Glu Ala Leu Ser Lys Ser Val Pro Val Thr Val Asp
385                 390                 395                 400 
Asp Asp Asp Asp Asp Asn Asp Pro Glu Asn Arg Ile Ala Lys Lys Met
                405                 410                 415     
Leu Leu Glu Glu Ile Lys Ala Asn Leu Ser Ser Asp Glu Asp Gly Ser
            420                 425                 430         
Ser Asp Asp Glu Pro Glu Glu Gly Lys Lys Arg Thr Gly Lys Gln Asn
        435                 440                 445             
Glu Glu Asn Pro Gly Asp Glu Glu Ala Lys Asn Gln Val Asn Ser Glu
    450                 455                 460                 
Ser Asp Ser Asp Ser Glu Glu Ser Lys Lys Pro Arg Tyr Arg His Arg
465                 470                 475                 480 
Leu Leu Arg His Lys Leu Thr Val Ser Asp Gly Glu Ser Gly Glu Glu
                485                 490                 495     
Lys Lys Thr Lys Pro Lys Glu His Lys Glu Val Lys Gly Arg Asn Arg
            500                 505                 510         
Arg Lys Val Ser Ser Glu Asp Ser Glu Asp Ser Asp Phe Gln Glu Ser
        515                 520                 525             
Gly Val Ser Glu Glu Val Ser Glu Ser Glu Asp Glu Gln Arg Pro Arg
    530                 535                 540                 
Thr Arg Ser Ala Lys Lys Ala Glu Leu Glu Glu Asn Gln Arg Ser Tyr
545                 550                 555                 560 
Lys Gln Lys Lys Lys Arg Arg Arg Ile Lys Val Gln Glu Asp Ser Ser
                565                 570                 575     
Ser Glu Asn Lys Ser Asn Ser Glu Glu Glu Glu Glu Glu Lys Glu Glu
            580                 585                 590         
Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Asn
        595                 600                 605             
Asp Asp Ser Lys Ser Pro Gly Lys Gly Arg Lys Lys Ile Arg Lys Ile
    610                 615                 620                 
Leu Lys Asp Asp Lys Leu Arg Thr Glu Thr Gln Asn Ala Leu Lys Glu
625                 630                 635                 640 
Glu Glu Glu Arg Arg Lys Arg Ile Ala Glu Arg Glu Arg Glu Arg Glu
                645                 650                 655     
Lys Leu Arg Glu Val Ile Glu Ile Glu Asp Ala Ser Pro Thr Lys Cys
            660                 665                 670         
Pro Ile Thr Thr Lys Leu Val Leu Asp Glu Asp Glu Glu Thr Lys Glu
        675                 680                 685             
Pro Leu Val Gln Val His Arg Asn Met Val Ile Lys Leu Lys Pro His
    690                 695                 700                 
Gln Val Asp Gly Val Gln Phe Met Trp Asp Cys Cys Cys Glu Ser Val
705                 710                 715                 720 
Lys Lys Thr Lys Lys Ser Pro Gly Ser Gly Cys Ile Leu Ala His Cys
                725                 730                 735     
Met Gly Leu Gly Lys Thr Leu Gln Val Val Ser Phe Leu His Thr Val
            740                 745                 750         
Leu Leu Cys Asp Lys Leu Asp Phe Ser Thr Ala Leu Val Gly Leu Ser
        755                 760                 765             
Ser Ser Ile Leu Ala Phe Asn Trp Met Asn Glu Phe Glu Lys Trp Gln
    770                 775                 780                 
Glu Gly Leu Lys Asp Asp Glu Lys Leu Glu Val Ser Glu Leu Ala Thr
785                 790                 795                 800 
Val Lys Arg Pro Gln Glu Arg Ser Tyr Met Leu Gln Arg Trp Gln Glu
                805                 810                 815     
Asp Gly Gly Val Met Ile Ile Gly Tyr Glu Met Tyr Arg Asn Leu Ala
            820                 825                 830         
Gln Gly Arg Asn Val Lys Ser Arg Lys Leu Lys Glu Ile Phe Asn Lys
        835                 840                 845             
Ala Leu Val Asp Pro Gly Pro Asp Phe Val Val Cys Asp Glu Gly His
    850                 855                 860                 
Ile Leu Lys Asn Glu Ala Ser Ala Val Ser Lys Ala Met Asn Ser Ile
865                 870                 875                 880 
Arg Ser Arg Arg Arg Ile Ile Leu Thr Gly Thr Pro Leu Gln Asn Asn
                885                 890                 895     
Leu Ile Glu Tyr His Cys Met Val Asn Phe Ile Lys Glu Asn Leu Leu
            900                 905                 910         
Gly Ser Ile Lys Glu Phe Arg Asn Arg Phe Ile Asn Pro Ile Gln Asn
        915                 920                 925             
Gly Gln Cys Ala Asp Ser Thr Met Val Asp Val Arg Val Met Lys Lys
    930                 935                 940                 
Arg Ala His Ile Leu Tyr Glu Met Leu Ala Gly Cys Val Gln Arg Lys
945                 950                 955                 960 
Asp Tyr Thr Ala Leu Thr Lys Phe Leu Pro Pro Lys His Glu Tyr Val
                965                 970                 975     
Leu Ala Val Arg Met Thr Ser Ile Gln Cys Lys Leu Tyr Gln Tyr Tyr
            980                 985                 990         
Leu Asp His Leu Thr Gly Val Gly Asn Asn Ser Glu Gly Gly Arg Gly
        995                 1000                1005            
Lys Ala Gly Ala Lys Leu Phe Gln Asp Phe Gln Met Leu Ser Arg Ile
    1010                1015                1020                
Trp Thr His Pro Trp Cys Leu Gln Leu Asp Tyr Ile Ser Lys Glu Asn
1025                1030                1035                1040
Lys Gly Tyr Phe Asp Glu Asp Ser Met Asp Glu Phe Ile Ala Ser Asp
                1045                1050                1055    
Ser Asp Glu Thr Ser Met Ser Leu Ser Ser Asp Asp Tyr Thr Lys Lys
            1060                1065                1070        
Lys Lys Lys Gly Lys Lys Gly Lys Lys Asp Ser Ser Ser Ser Gly Ser
        1075                1080                1085            
Gly Ser Asp Asn Asp Val Glu Val Ile Lys Val Trp Asn Ser Arg Ser
    1090                1095                1100                
Arg Gly Gly Gly Glu Gly Asn Val Asp Glu Thr Gly Asn Asn Pro Ser
1105                1110                1115                1120
Val Ser Leu Lys Leu Glu Glu Ser Lys Ala Thr Ser Ser Ser Asn Pro
                1125                1130                1135    
Ser Ser Pro Ala Pro Asp Trp Tyr Lys Asp Phe Val Thr Asp Ala Asp
            1140                1145                1150        
Ala Glu Val Leu Glu His Ser Gly Lys Met Val Leu Leu Phe Glu Ile
        1155                1160                1165            
Leu Arg Met Ala Glu Glu Ile Gly Asp Lys Val Leu Val Phe Ser Gln
    1170                1175                1180                
Ser Leu Ile Ser Leu Asp Leu Ile Glu Asp Phe Leu Glu Leu Ala Ser
1185                1190                1195                1200
Arg Glu Lys Thr Glu Asp Lys Asp Lys Pro Leu Ile Tyr Lys Gly Glu
                1205                1210                1215    
Gly Lys Trp Leu Arg Asn Ile Asp Tyr Tyr Arg Leu Asp Gly Ser Thr
            1220                1225                1230        
Thr Ala Gln Ser Arg Lys Lys Trp Ala Glu Glu Phe Asn Asp Glu Thr
        1235                1240                1245            
Asn Val Arg Gly Arg Leu Phe Ile Ile Ser Thr Lys Ala Gly Ser Leu
    1250                1255                1260                
Gly Ile Asn Leu Val Ala Ala Asn Arg Val Ile Ile Phe Asp Ala Ser
1265                1270                1275                1280
Trp Asn Pro Ser Tyr Asp Ile Gln Ser Ile Phe Arg Val Tyr Arg Phe
                1285                1290                1295    
Gly Gln Thr Lys Pro Val Tyr Val Tyr Arg Phe Leu Ala Gln Gly Thr
            1300                1305                1310        
Met Glu Asp Lys Ile Tyr Asp Arg Gln Val Thr Lys Gln Ser Leu Ser
        1315                1320                1325            
Phe Arg Val Val Asp Gln Gln Gln Val Glu Arg His Phe Thr Met Asn
    1330                1335                1340                
Glu Leu Thr Glu Leu Tyr Thr Phe Glu Pro Asp Leu Leu Asp Asp Pro
1345                1350                1355                1360
Asn Ser Glu Lys Lys Lys Lys Arg Asp Thr Pro Met Leu Pro Lys Asp
                1365                1370                1375    
Thr Ile Leu Ala Glu Leu Leu Gln Ile His Lys Glu His Ile Val Gly
            1380                1385                1390        
Tyr His Glu His Asp Ser Leu Leu Thr Thr Lys Lys Lys Lys Arg Leu
        1395                1400                1405            
Thr Glu Glu Glu Arg Lys Ala Ala Trp Ala Glu Tyr Glu Gly Glu Lys
    1410                1415                1420                
Arg Val Leu Thr Met Arg Phe Asn Ile Pro Thr Gly Thr Asn Leu Pro
1425                1430                1435                1440
Pro Val Ser Phe Asn Ser Gln Thr Pro Tyr Ile Pro Phe Asn Leu Gly
                1445                1450                1455    
Ala Leu Ser Ala Met Ser Asn Gln Gln Leu Glu Asp Leu Ile Asn Gln
            1460                1465                1470        
Gly Arg Glu Lys Val Val Glu Ala Thr Asn Ser Val Thr Ala Val Arg
        1475                1480                1485            
Ile Gln Pro Leu Glu Asp Ile Ile Ser Ala Val Trp Lys Glu Asn Met
    1490                1495                1500                
Asn Leu Ser Glu Ala Gln Val Gln Ala Leu Ala Leu Ser Arg Gln Ala
1505                1510                1515                1520
Ser Gln Glu Leu Asp Val Lys Arg Arg Glu Ala Ile Tyr Asn Asp Val
                1525                1530                1535    
Leu Thr Lys Gln Gln Met Leu Ile Gln Leu Cys Ser Ala Asn Thr Tyr
            1540                1545                1550        
Glu Gln Lys Ala Pro Ala Ala Val Gln Ser Ala Ala Thr Ala Thr Asn
        1555                1560                1565            
Asp Leu Ser Thr Thr Thr Leu Gly His His Met Met Pro Lys Pro Arg
    1570                1575                1580                
Asn Leu Ile Met Asn Pro Ser Asn Tyr Gln Gln Ile Asp Met Arg Gly
1585                1590                1595                1600
Met Tyr Gln Pro Val Ala Gly Gly Met Gln Pro Pro Pro Leu Gln Arg
                1605                1610                1615    
Cys Thr Thr Pro Asn Glu Lys Gln Lys Ile Gln Asp Leu Pro Lys Gly
            1620                1625                1630        
Asn Gln Cys Asp Phe Ala Leu Lys Ala
        1635                1640    


<210> 816
<211> 194
<212> PRT
<213> Homo sapiens

<400> 816
Trp Ser Val Thr Arg Pro Gly Asp Arg Pro Asp Met Trp Cys Pro His
 1               5                  10                  15      
Pro Glu Gly Arg Pro Trp Arg Asp Asp Pro Pro Leu Pro Pro Pro Pro
            20                  25                  30          
Ile Arg Leu Trp Thr Pro Ser Ser Leu Pro Pro Ser Thr Leu Pro Asp
        35                  40                  45              
Pro Pro Lys Ser Pro Gly Ser Ser Leu Pro Gln Gly Thr Arg Ser Thr
    50                  55                  60                  
Ala Pro Ser Ile Pro Asn Gly Pro Asp Ser Gln Arg Gly Val Arg Lys
65                  70                  75                  80  
Glu Lys Ala Ile Ser His Arg Leu Ile Leu Leu Ala Pro Gly Ser Ser
                85                  90                  95      
Thr Gly Arg Arg Val Gly Leu Cys Arg His Asp Gly Ser Val Val Arg
            100                 105                 110         
Glu Gly Pro Pro Pro Met Cys Leu Gly Arg Gly Pro Pro Lys Pro Leu
        115                 120                 125             
Arg Gly Ser Ala Lys Gly Leu Glu Ser Ala Pro Ala His Thr Gly Pro
    130                 135                 140                 
Cys Ser Leu Val Ala Ile Val Ser Ala Thr Ser Thr Phe Arg Ser Leu
145                 150                 155                 160 
Pro Arg Ala Cys Pro Arg Ser Leu Ser Pro Pro Trp His Ala Pro Leu
                165                 170                 175     
Cys Pro His Thr Leu Cys Val Ser Gly Asp Ser Gly Asp Ser Ser Gly
            180                 185                 190         
Val Thr
        


<210> 817
<211> 407
<212> PRT
<213> Homo sapiens

<400> 817
Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln Pro Glu Ser Pro Thr Ala
 1               5                  10                  15      
Ser Ala Gly Asp Glu Pro Arg Ser Thr Pro Glu Ser Gly Asp Ser Asp
            20                  25                  30          
Lys Glu Ser Val Gly Ser Ser Ser Thr Ser Asn Glu Gly Gly Arg Arg
        35                  40                  45              
Lys Glu Lys Ser Lys Arg Asp Arg Glu Lys Asp Lys Lys Arg Ala Asp
    50                  55                  60                  
Ser Val Ala Asn Lys Leu Gly Ser Phe Gly Lys Thr Leu Gly Ser Lys
65                  70                  75                  80  
Leu Lys Lys Asn Met Gly Gly Leu Met His Ser Lys Gly Ser Lys Pro
                85                  90                  95      
Gly Gly Val Gly Thr Gly Leu Gly Gly Ser Ser Gly Thr Glu Thr Leu
            100                 105                 110         
Glu Lys Lys Lys Lys Asn Ser Leu Lys Ser Trp Lys Gly Gly Lys Glu
        115                 120                 125             
Glu Ala Ala Gly Asp Gly Pro Val Ser Glu Lys Pro Pro Ala Glu Ser
    130                 135                 140                 
Val Gly Asn Gly Gly Ser Lys Tyr Ser Gln Glu Val Met Gln Ser Leu
145                 150                 155                 160 
Ser Ile Leu Arg Thr Ala Met Gln Gly Glu Gly Lys Phe Ile Phe Val
                165                 170                 175     
Gly Thr Leu Lys Met Gly His Arg His Gln Tyr Gln Glu Glu Met Ile
            180                 185                 190         
Gln Arg Tyr Leu Ser Asp Ala Glu Glu Arg Phe Leu Ala Glu Gln Lys
        195                 200                 205             
Gln Lys Glu Ala Glu Arg Lys Ile Met Asn Gly Gly Ile Gly Gly Gly
    210                 215                 220                 
Pro Pro Pro Ala Lys Lys Pro Glu Pro Asp Ala Arg Glu Glu Gln Pro
225                 230                 235                 240 
Thr Gly Pro Pro Ala Glu Ser Arg Ala Met Ala Phe Ser Thr Gly Tyr
                245                 250                 255     
Pro Gly Asp Phe Thr Ile Pro Arg Pro Ser Gly Gly Gly Val His Cys
            260                 265                 270         
Gln Glu Pro Arg Arg Gln Leu Ala Gly Gly Pro Cys Val Gly Gly Leu
        275                 280                 285             
Pro Pro Tyr Ala Thr Phe Pro Arg Gln Cys Pro Pro Gly Arg Pro Tyr
    290                 295                 300                 
Pro His Gln Asp Ser Ile Pro Ser Leu Glu Pro Gly Ser His Ser Lys
305                 310                 315                 320 
Asp Gly Leu His Arg Gly Ala Leu Leu Pro Pro Pro Tyr Arg Val Ala
                325                 330                 335     
Asp Ser Tyr Ser Asn Gly Tyr Arg Glu Pro Pro Glu Pro Asp Gly Trp
            340                 345                 350         
Ala Gly Gly Leu Arg Gly Leu Pro Pro Thr Gln Thr Lys Cys Lys Gln
        355                 360                 365             
Pro Asn Cys Ser Phe Tyr Gly His Pro Glu Thr Asn Asn Phe Cys Ser
    370                 375                 380                 
Cys Cys Tyr Arg Glu Glu Leu Arg Arg Arg Glu Arg Glu Pro Asp Gly
385                 390                 395                 400 
Glu Leu Leu Val His Arg Phe
                405         


<210> 818
<211> 321
<212> PRT
<213> Homo sapiens

<400> 818
Val Ser Ser Asp Gly Thr Ser Trp Thr Leu Leu Gly Leu Pro Ala Val
 1               5                  10                  15      
Ser His Leu Asp Ser Gly Asp Tyr Ile Cys Gln Ala Lys Asn Phe Leu
            20                  25                  30          
Gly Ala Ser Glu Thr Val Ile Ser Leu Ile Val Thr Glu Pro Pro Thr
        35                  40                  45              
Ser Thr Glu His Ser Gly Ser Pro Gly Ala Leu Trp Ala Arg Thr Gly
    50                  55                  60                  
Gly Gly Gly Glu Ala Ala Ala Tyr Asn Asn Lys Leu Val Ala Arg His
65                  70                  75                  80  
Val Pro Gln Ile Pro Lys Pro Ala Val Leu Ala Thr Gly Pro Ser Val
                85                  90                  95      
Pro Ser Thr Lys Glu Glu Leu Thr Leu Glu His Phe Gln Met Asp Ala
            100                 105                 110         
Leu Gly Glu Leu Ser Asp Gly Arg Ala Gly Pro Ser Glu Ala Arg Met
        115                 120                 125             
Val Arg Ser Val Lys Val Val Gly Asp Thr Tyr His Ser Val Ser Leu
    130                 135                 140                 
Val Trp Lys Ala Pro Gln Ala Lys Asn Thr Thr Ala Phe Ser Val Leu
145                 150                 155                 160 
Tyr Ala Val Phe Gly Gln His Ser Met Arg Arg Val Ile Val Gln Pro
                165                 170                 175     
Gly Lys Thr Arg Val Thr Ile Thr Gly Leu Leu Pro Lys Thr Lys Tyr
            180                 185                 190         
Val Ala Cys Val Cys Val Gln Gly Leu Val Pro Arg Lys Glu Gln Cys
        195                 200                 205             
Val Ile Phe Ser Thr Asn Glu Val Val Asp Ala Glu Asn Thr Gln Gln
    210                 215                 220                 
Leu Ile Asn Val Val Val Ile Ser Val Ala Ile Val Ile Ala Leu Pro
225                 230                 235                 240 
Leu Thr Leu Leu Val Cys Cys Ser Ala Leu Gln Lys Arg Cys Arg Lys
                245                 250                 255     
Cys Phe Asn Lys Asp Ser Thr Glu Ala Thr Val Thr Tyr Val Asn Leu
            260                 265                 270         
Glu Arg Leu Gly Tyr Ser Glu Asp Gly Leu Glu Glu Leu Ser Arg His
        275                 280                 285             
Ser Val Ser Glu Ala Asp Arg Leu Leu Ser Ala Arg Ser Ser Val Asp
    290                 295                 300                 
Phe Gln Ala Phe Gly Val Lys Gly Gly Arg Arg Ile Asn Glu Tyr Phe
305                 310                 315                 320 
Cys
    


<210> 819
<211> 207
<212> PRT
<213> Homo sapiens

<400> 819
Gly Val Arg Ala Gly Arg Ala Ser Ala Ser Ser Arg Arg Asn Leu Ser
 1               5                  10                  15      
Arg Leu Pro Arg Pro Arg Cys Pro Lys Pro Gln Arg Leu Glu Leu Gly
            20                  25                  30          
Ala Arg Ser Leu Ala Pro Thr Ala Trp Pro Gly Val Arg Asp Ala Thr
        35                  40                  45              
Arg Ala Pro Arg Arg Gly His Arg Leu Ser Pro Ala Asp Asp Glu Leu
    50                  55                  60                  
Tyr Gln Arg Thr Arg Ile Ser Leu Leu Gln Arg Glu Ala Ala Gln Ala
65                  70                  75                  80  
Met Tyr Ile Asp Ser Tyr Asn Ser Arg Gly Phe Met Ile Asn Gly Asn
                85                  90                  95      
Arg Val Leu Gly Pro Cys Ala Leu Leu Pro His Ser Val Val Gln Trp
            100                 105                 110         
Asn Val Gly Ser His Gln Asp Ile Thr Glu Asp Ser Phe Ser Leu Phe
        115                 120                 125             
Trp Leu Leu Glu Pro Arg Ile Glu Ile Val Val Val Gly Thr Gly Asp
    130                 135                 140                 
Arg Thr Glu Arg Leu Gln Ser Gln Val Leu Gln Ala Met Arg Gln Arg
145                 150                 155                 160 
Gly Ile Ala Val Glu Val Gln Asp Thr Pro Asn Ala Cys Ala Thr Phe
                165                 170                 175     
Asn Phe Leu Cys His Glu Gly Arg Val Thr Gly Ala Ala Leu Ile Pro
            180                 185                 190         
Pro Pro Gly Gly Thr Ser His Thr Ser Leu Gly Gln Ala Ala Gln
        195                 200                 205         


<210> 820
<211> 207
<212> PRT
<213> Homo sapiens

<400> 820
Gly Val Arg Ala Gly Arg Ala Ser Ala Ser Ser Arg Arg Asn Leu Ser
 1               5                  10                  15      
Arg Leu Pro Arg Pro Arg Cys Pro Lys Pro Gln Arg Leu Glu Leu Gly
            20                  25                  30          
Ala Arg Ser Leu Ala Pro Thr Ala Trp Pro Gly Val Arg Asp Ala Thr
        35                  40                  45              
Arg Ala Pro Arg Arg Gly His Arg Leu Ser Pro Ala Asp Asp Glu Leu
    50                  55                  60                  
Tyr Gln Arg Thr Arg Ile Ser Leu Leu Gln Arg Glu Ala Ala Gln Ala
65                  70                  75                  80  
Met Tyr Ile Asp Ser Tyr Asn Ser Arg Gly Phe Met Ile Asn Gly Asn
                85                  90                  95      
Arg Val Leu Gly Pro Cys Ala Leu Leu Pro His Ser Val Val Gln Trp
            100                 105                 110         
Asn Val Gly Ser His Gln Asp Ile Thr Glu Asp Ser Phe Ser Leu Phe
        115                 120                 125             
Trp Leu Leu Glu Pro Arg Ile Glu Ile Val Val Val Gly Thr Gly Asp
    130                 135                 140                 
Arg Thr Glu Arg Leu Gln Ser Gln Val Leu Gln Ala Met Arg Gln Arg
145                 150                 155                 160 
Gly Ile Ala Val Glu Val Gln Asp Thr Pro Asn Ala Cys Ala Thr Phe
                165                 170                 175     
Asn Phe Leu Cys His Glu Gly Arg Val Thr Gly Ala Ala Leu Ile Pro
            180                 185                 190         
Pro Pro Gly Gly Thr Ser His Thr Ser Leu Gly Gln Ala Ala Gln
        195                 200                 205         


<210> 821
<211> 450
<212> PRT
<213> Homo sapiens

<400> 821
Gly Gly Thr Pro Arg Ala Ala Ala Thr Arg Arg Glu Ala Ala Ala Leu
 1               5                  10                  15      
Pro Pro Val Thr Leu Ala Leu Leu Cys Leu Asp Gly Val Phe Leu Ser
            20                  25                  30          
Ser Ala Glu Asn Asp Phe Val His Arg Ile Gln Glu Glu Leu Asp Arg
        35                  40                  45              
Phe Leu Leu Gln Lys Gln Leu Ser Lys Val Leu Leu Phe Pro Pro Leu
    50                  55                  60                  
Ser Ser Arg Leu Arg Tyr Leu Ile His Arg Thr Ala Glu Asn Phe Asp
65                  70                  75                  80  
Leu Leu Ser Ser Phe Ser Val Gly Glu Gly Trp Lys Arg Arg Thr Val
                85                  90                  95      
Ile Cys His Gln Asp Ile Arg Val Pro Ser Ser Asp Gly Leu Ser Gly
            100                 105                 110         
Pro Cys Arg Ala Pro Ala Ser Cys Pro Arg Arg Tyr His Gly Pro Arg
        115                 120                 125             
Pro Ile Ser Asn Gln Gly Ala Ala Ala Val Pro Arg Gly Ala Arg Ala
    130                 135                 140                 
Gly Arg Trp Tyr Arg Gly Arg Lys Pro Asp Gln Pro Leu Tyr Val Pro
145                 150                 155                 160 
Arg Val Leu Arg Arg Gln Glu Glu Trp Gly Leu Thr Ser Thr Ser Val
                165                 170                 175     
Leu Lys Arg Glu Ala Pro Ala Gly Arg Asp Pro Glu Glu Pro Gly Asp
            180                 185                 190         
Val Gly Ala Gly Asp Pro Asn Ser Asp Gln Gly Leu Pro Val Leu Met
        195                 200                 205             
Thr Gln Gly Thr Glu Asp Leu Lys Gly Pro Gly Gln Arg Cys Glu Asn
    210                 215                 220                 
Glu Pro Leu Leu Asp Pro Val Gly Pro Glu Pro Leu Gly Pro Glu Ser
225                 230                 235                 240 
Gln Ser Gly Lys Gly Asp Met Val Glu Met Ala Thr Arg Phe Gly Ser
                245                 250                 255     
Thr Leu Gln Leu Asp Leu Glu Lys Gly Lys Glu Ser Leu Leu Glu Lys
            260                 265                 270         
Arg Leu Val Ala Glu Glu Glu Glu Asp Glu Glu Glu Val Glu Glu Asp
        275                 280                 285             
Gly Pro Ser Ser Cys Ser Glu Asp Asp Tyr Ser Glu Leu Leu Gln Glu
    290                 295                 300                 
Ile Thr Asp Asn Leu Thr Lys Lys Glu Ile Gln Ile Glu Lys Ile His
305                 310                 315                 320 
Leu Asp Thr Ser Ser Phe Val Glu Glu Leu Pro Gly Glu Lys Asp Leu
                325                 330                 335     
Ala His Val Val Glu Ile Tyr Asp Phe Glu Pro Ala Leu Lys Thr Glu
            340                 345                 350         
Asp Leu Leu Ala Thr Phe Ser Glu Phe Gln Glu Lys Gly Phe Arg Ile
        355                 360                 365             
Gln Trp Val Asp Asp Thr His Ala Leu Gly Ile Phe Pro Cys Leu Ala
    370                 375                 380                 
Ser Ala Ala Glu Ala Leu Thr Arg Glu Phe Ser Ala Leu Lys Ile Arg
385                 390                 395                 400 
Pro Leu Thr Gln Gly Thr Lys Gln Ser Lys Leu Lys Ala Leu Gln Arg
                405                 410                 415     
Pro Lys Leu Leu Arg Leu Val Lys Glu Arg Pro Gln Thr Asn Ala Thr
            420                 425                 430         
Val Ala Arg Arg Leu Val Ala Arg Ala Leu Gly Leu Gln His Lys Lys
        435                 440                 445             
Lys Lys
    450 


<210> 822
<211> 1696
<212> PRT
<213> Homo sapiens

<400> 822
Arg Ser Arg Pro Ser Ala Pro Glu Thr Asp Asp Ser Arg Val Gly Gly
 1               5                  10                  15      
Ile Met Arg Gly Glu Lys Asn Tyr Tyr Phe Arg Gly Ala Ala Gly Asp
            20                  25                  30          
His Gly Ser Cys Pro Thr Thr Thr Ser Pro Leu Ala Ser Ala Leu Leu
        35                  40                  45              
Met Pro Ser Glu Ala Val Ser Ser Ser Trp Ser Glu Ser Gly Gly Gly
    50                  55                  60                  
Leu Ser Gly Gly Asp Glu Glu Asp Thr Arg Leu Leu Gln Leu Leu Arg
65                  70                  75                  80  
Thr Ala Arg Asp Pro Ser Glu Ala Phe Gln Ala Leu Gln Ala Ala Leu
                85                  90                  95      
Pro Arg Arg Gly Gly Arg Leu Gly Phe Pro Arg Arg Lys Glu Ala Leu
            100                 105                 110         
Tyr Arg Ala Leu Gly Arg Val Leu Val Glu Gly Gly Ser Asp Glu Lys
        115                 120                 125             
Arg Leu Cys Leu Gln Leu Leu Ser Asp Val Leu Arg Gly Gln Gly Glu
    130                 135                 140                 
Ala Gly Gln Leu Glu Glu Ala Phe Ser Leu Ala Leu Leu Pro Gln Leu
145                 150                 155                 160 
Val Val Ser Leu Arg Glu Glu Asn Pro Ala Leu Arg Lys Asp Ala Leu
                165                 170                 175     
Gln Ile Leu His Ile Cys Leu Lys Arg Ser Pro Gly Glu Val Leu Arg
            180                 185                 190         
Thr Leu Ile Gln Gln Gly Leu Glu Ser Thr Asp Ala Arg Leu Arg Ala
        195                 200                 205             
Ser Thr Ala Leu Leu Leu Pro Ile Leu Leu Thr Thr Glu Asp Leu Leu
    210                 215                 220                 
Leu Gly Leu Asp Leu Thr Glu Val Ile Ile Ser Leu Ala Arg Lys Leu
225                 230                 235                 240 
Gly Asp Gln Glu Thr Glu Glu Glu Ser Glu Thr Ala Phe Ser Ala Leu
                245                 250                 255     
Gln Gln Ile Gly Glu Arg Leu Gly Gln Asp Arg Phe Gln Ser Tyr Ile
            260                 265                 270         
Ser Arg Leu Pro Ser Ala Leu Arg Arg His Tyr Asn Arg Arg Leu Glu
        275                 280                 285             
Ser Gln Phe Gly Ser Gln Val Pro Tyr Tyr Leu Glu Leu Glu Ala Ser
    290                 295                 300                 
Gly Phe Pro Glu Asp Pro Leu Pro Cys Ala Val Thr Leu Ser Asn Ser
305                 310                 315                 320 
Asn Leu Lys Phe Gly Ile Ile Pro Gln Glu Leu His Ser Arg Leu Leu
                325                 330                 335     
Asp Gln Glu Asp Tyr Lys Asn Arg Thr Gln Ala Val Glu Glu Leu Lys
            340                 345                 350         
Gln Val Leu Gly Lys Phe Asn Pro Ser Ser Thr Pro His Ser Ser Leu
        355                 360                 365             
Val Gly Phe Ile Ser Leu Leu Tyr Asn Leu Leu Asp Asp Ser Asn Phe
    370                 375                 380                 
Lys Val Val His Gly Thr Leu Glu Val Leu His Leu Leu Val Ile Arg
385                 390                 395                 400 
Leu Gly Glu Gln Val Gln Gln Phe Leu Gly Pro Val Ile Ala Ala Ser
                405                 410                 415     
Val Lys Val Leu Ala Asp Asn Lys Leu Val Ile Lys Gln Glu Tyr Met
            420                 425                 430         
Lys Ile Phe Leu Lys Leu Met Lys Glu Val Gly Pro Gln Gln Val Leu
        435                 440                 445             
Cys Leu Leu Leu Lys His Leu Lys His Lys His Ser Arg Val Arg Glu
    450                 455                 460                 
Glu Val Val Asn Ile Cys Ile Cys Ser Leu Leu Thr Tyr Pro Ser Glu
465                 470                 475                 480 
Asp Phe Asp Leu Pro Lys Leu Ser Phe Asp Leu Ala Pro Ala Leu Val
                485                 490                 495     
Asp Ser Lys Arg Arg Val Arg Gln Ala Ala Leu Glu Ala Phe Ala Val
            500                 505                 510         
Leu Ala Ser Ser Met Gly Ser Gly Lys Thr Ser Ile Leu Phe Lys Ala
        515                 520                 525             
Val Asp Thr Val Glu Leu Gln Asp Asn Gly Asp Gly Val Met Asn Ala
    530                 535                 540                 
Val Gln Ala Arg Leu Ala Arg Lys Thr Leu Pro Arg Leu Thr Glu Gln
545                 550                 555                 560 
Gly Phe Val Glu Tyr Ala Val Leu Met Pro Ser Ser Ala Gly Gly Arg
                565                 570                 575     
Ser Asn His Leu Ala His Gly Ala Asp Thr Asp Trp Leu Leu Ala Gly
            580                 585                 590         
Asn Arg Thr Gln Ser Ala His Cys His Cys Gly Asp His Val Arg Asp
        595                 600                 605             
Ser Met His Ile Tyr Gly Ser Tyr Ser Pro Thr Ile Cys Thr Arg Arg
    610                 615                 620                 
Val Leu Ser Ala Gly Lys Gly Lys Asn Lys Leu Pro Trp Glu Asn Glu
625                 630                 635                 640 
Gln Pro Gly Ile Met Gly Glu Asn Gln Thr Ser Thr Ser Lys Asp Ile
                645                 650                 655     
Glu Gln Phe Ser Thr Tyr Asp Phe Ile Pro Ser Ala Lys Leu Lys Leu
            660                 665                 670         
Ser Gln Gly Met Pro Val Asn Asp Asp Leu Cys Phe Ser Arg Lys Arg
        675                 680                 685             
Val Ser Arg Asn Leu Phe Gln Asn Ser Arg Asp Phe Asn Pro Asp Cys
    690                 695                 700                 
Leu Pro Leu Cys Ala Ala Gly Thr Thr Gly Thr His Gln Thr Asn Leu
705                 710                 715                 720 
Ser Gly Lys Cys Ala Gln Leu Gly Phe Ser Gln Ile Cys Gly Lys Thr
                725                 730                 735     
Gly Ser Val Gly Ser Asp Leu Gln Phe Leu Gly Thr Thr Ser Ser His
            740                 745                 750         
Gln Glu Lys Val Tyr Ala Ser Leu Asn Phe Gly Ser Lys Thr Gln Gln
        755                 760                 765             
Thr Phe Gly Ser Gln Thr Glu Cys Thr Ser Ser Asn Gly Gln Asn Pro
    770                 775                 780                 
Ser Pro Gly Ala Tyr Ile Leu Pro Ser Tyr Pro Val Ser Ser Pro Arg
785                 790                 795                 800 
Thr Ser Pro Lys His Thr Ser Pro Leu Ile Ile Ser Pro Lys Lys Ser
                805                 810                 815     
Gln Asp Asn Ser Val Asn Phe Ser Asn Ser Trp Pro Leu Lys Ser Phe
            820                 825                 830         
Glu Gly Leu Ser Lys Pro Ser Pro Gln Lys Lys Leu Val Ser Gln Lys
        835                 840                 845             
Ser Ser Asp Pro Thr Gly Arg Asn His Gly Glu Asn Ser Gln Glu Lys
    850                 855                 860                 
Pro Pro Val Gln Leu Thr Pro Ala Leu Val Arg Ser Pro Ser Ser Arg
865                 870                 875                 880 
Arg Gly Leu Asn Gly Thr Lys Pro Val Pro Pro Ile Pro Arg Gly Ile
                885                 890                 895     
Ser Leu Leu Pro Asp Lys Ala Asp Leu Ser Thr Val Gly His Lys Lys
            900                 905                 910         
Lys Glu Pro Asp Asp Ile Trp Lys Cys Glu Lys Asp Ser Leu Pro Ile
        915                 920                 925             
Asp Leu Ser Glu Leu Asn Phe Lys Asp Lys Asp Leu Asp Gln Glu Glu
    930                 935                 940                 
Met His Ser Ser Leu Arg Ser Leu Arg Asn Ser Ala Ala Lys Lys Arg
945                 950                 955                 960 
Ala Lys Leu Ser Gly Ser Thr Leu Asp Leu Glu Ser Pro Asp Ser Ala
                965                 970                 975     
Met Lys Leu Asp Leu Thr Met Asp Ser Pro Ser Leu Ser Ser Ser Pro
            980                 985                 990         
Asn Ile Asn Ser Tyr Ser Glu Ser Gly Val Tyr Ser Gln Glu Ser Leu
        995                 1000                1005            
Thr Ser Ser Leu Ser Thr Thr Pro Gln Gly Lys Arg Ile Met Ser Asp
    1010                1015                1020                
Ile Phe Pro Thr Phe Gly Ser Lys Pro Cys Pro Thr Arg Leu Ser Ser
1025                1030                1035                1040
Ala Lys Lys Lys Ile Ser His Ile Ala Glu Gln Ser Pro Ser Ala Gly
                1045                1050                1055    
Ser Ser Ser Asn Pro Gln Gln Ile Ser Ser Phe Asp Phe Thr Thr Thr
            1060                1065                1070        
Lys Ala Leu Ser Glu Asp Ser Val Val Val Val Gly Lys Gly Val Phe
        1075                1080                1085            
Gly Ser Leu Ser Ser Ala Pro Ala Thr Cys Ser Gln Ser Val Ile Ser
    1090                1095                1100                
Ser Val Glu Asn Gly Asp Thr Phe Ser Ile Lys Gln Ser Ile Glu Pro
1105                1110                1115                1120
Pro Ser Gly Ile Tyr Gly Arg Ser Val Gln Gln Asn Ile Ser Ser Tyr
                1125                1130                1135    
Leu Asp Val Glu Asn Glu Lys Asp Ala Lys Val Ser Ile Ser Lys Ser
            1140                1145                1150        
Thr Tyr Asn Lys Met Arg Gln Lys Arg Lys Glu Glu Lys Glu Leu Phe
        1155                1160                1165            
His Asn Lys Asp Cys Glu Lys Lys Glu Lys Asn Ser Trp Glu Arg Met
    1170                1175                1180                
Arg His Thr Gly Thr Glu Lys Met Ala Ser Glu Ser Glu Thr Pro Thr
1185                1190                1195                1200
Gly Ala Ile Ser Gln Tyr Lys Glu Arg Met Pro Ser Val Thr His Ser
                1205                1210                1215    
Pro Glu Ile Met Asp Leu Ser Glu Leu Arg Pro Phe Ser Lys Pro Glu
            1220                1225                1230        
Ile Ala Leu Thr Glu Ala Leu Arg Leu Leu Ala Asp Glu Asp Trp Glu
        1235                1240                1245            
Lys Lys Ile Glu Gly Leu Asn Phe Ile Arg Cys Leu Ala Ala Phe His
    1250                1255                1260                
Ser Glu Ile Leu Asn Thr Lys Leu His Glu Thr Asn Phe Ala Val Val
1265                1270                1275                1280
Gln Glu Val Lys Asn Leu Arg Ser Gly Val Ser Arg Ala Ala Val Val
                1285                1290                1295    
Cys Leu Ser Asp Leu Phe Thr Tyr Leu Lys Lys Ser Met Asp Gln Glu
            1300                1305                1310        
Leu Asp Thr Thr Val Lys Val Leu Leu His Lys Ala Gly Glu Ser Asn
        1315                1320                1325            
Thr Phe Ile Arg Glu Asp Val Asp Lys Ala Leu Arg Ala Met Val Asn
    1330                1335                1340                
Asn Val Thr Pro Ala Arg Ala Val Val Ser Leu Ile Asn Gly Gly Gln
1345                1350                1355                1360
Arg Tyr Tyr Gly Arg Lys Met Leu Phe Phe Met Met Cys His Pro Asn
                1365                1370                1375    
Phe Glu Lys Met Leu Glu Lys Tyr Val Pro Ser Lys Asp Leu Pro Tyr
            1380                1385                1390        
Ile Lys Asp Ser Val Arg Asn Leu Gln Gln Lys Gly Leu Gly Glu Ile
        1395                1400                1405            
Pro Leu Asp Thr Pro Ser Ala Lys Gly Arg Arg Ser His Thr Gly Ser
    1410                1415                1420                
Val Gly Asn Thr Arg Ser Ser Ser Val Ser Arg Asp Ala Phe Asn Ser
1425                1430                1435                1440
Ala Glu Arg Ala Val Thr Glu Val Arg Glu Val Thr Arg Lys Ser Val
                1445                1450                1455    
Pro Arg Asn Ser Leu Glu Ser Ala Glu Tyr Leu Lys Leu Ile Thr Gly
            1460                1465                1470        
Leu Leu Asn Ala Lys Asp Phe Arg Asp Arg Ile Asn Gly Ile Lys Gln
        1475                1480                1485            
Leu Leu Ser Asp Thr Glu Asn Asn Gln Asp Leu Val Val Gly Asn Ile
    1490                1495                1500                
Val Lys Ile Phe Asp Ala Phe Lys Ser Arg Leu His Asp Ser Asn Ser
1505                1510                1515                1520
Lys Val Asn Leu Val Ala Leu Glu Thr Met His Lys Met Ile Pro Leu
                1525                1530                1535    
Leu Arg Asp His Leu Ser Pro Ile Ile Asn Met Leu Ile Pro Ala Ile
            1540                1545                1550        
Val Asp Asn Asn Leu Asn Ser Lys Asn Pro Gly Ile Tyr Ala Ala Ala
        1555                1560                1565            
Thr Asn Val Val Gln Ala Leu Ser Gln His Val Asp Asn Tyr Leu Leu
    1570                1575                1580                
Leu Gln Pro Phe Cys Thr Lys Ala Gln Phe Leu Asn Gly Lys Ala Lys
1585                1590                1595                1600
Gln Asp Met Thr Glu Lys Leu Ala Asp Ile Val Thr Glu Leu Tyr Gln
                1605                1610                1615    
Arg Lys Pro His Ala Thr Glu Gln Lys Val Leu Val Val Leu Trp His
            1620                1625                1630        
Leu Leu Gly Asn Met Thr Asn Ser Gly Ser Leu Pro Gly Ala Gly Gly
        1635                1640                1645            
Asn Ile Arg Thr Ala Thr Ala Lys Leu Ser Lys Ala Leu Phe Ala Gln
    1650                1655                1660                
Met Gly Gln Asn Leu Leu Asn Gln Ala Ala Ser Gln Pro Pro His Ile
1665                1670                1675                1680
Lys Lys Ser Leu Glu Glu Leu Leu Asp Met Thr Ile Leu Asn Glu Leu
                1685                1690                1695    


<210> 823
<211> 1637
<212> PRT
<213> Homo sapiens

<400> 823
Leu Gln Lys Val Phe Val Ala Phe Arg Glu Phe Asn Leu Ser Glu Ser
 1               5                  10                  15      
Lys Val Cys Glu Leu Gln Leu Pro Asp Ile Asn Leu Val Asn Asp Gln
            20                  25                  30          
Lys Lys Leu Val Ser Ser Asp Leu Trp Arg Ile Val Leu Asn Ser Ser
        35                  40                  45              
Gln Asn Gly Ala Asp Asp Gln Ser Ser Ala Ser Glu Ser Gly Ser Gln
    50                  55                  60                  
Ser Thr Cys Asp Pro Leu Val Thr Pro Thr Ala Leu Ala Ala Cys Thr
65                  70                  75                  80  
Arg Val Asp Ser Cys Phe Thr Pro Trp Phe Val Pro Ser Leu Cys Val
                85                  90                  95      
Ser Phe Gln Phe Ala His Leu Glu Phe His Leu Cys His His Leu Asp
            100                 105                 110         
Gln Leu Gly Thr Ala Ala Pro Gln Tyr Leu Gln Pro Phe Val Ser Asp
        115                 120                 125             
Arg Asn Met Pro Ser Glu Leu Glu Tyr Met Ile Val Ser Phe Arg Glu
    130                 135                 140                 
Pro His Met Tyr Leu Arg Gln Trp Asn Asn Gly Ser Val Cys Gln Glu
145                 150                 155                 160 
Ile Gln Phe Leu Ala Gln Ala Asp Cys Lys Leu Leu Glu Cys Arg Asn
                165                 170                 175     
Val Thr Met Gln Ser Val Val Lys Pro Phe Ser Ile Phe Gly Gln Met
            180                 185                 190         
Ala Val Ser Ser Asp Val Val Glu Lys Leu Leu Asp Cys Thr Val Ile
        195                 200                 205             
Val Asp Ser Val Phe Val Asn Leu Gly Gln His Val Val His Ser Leu
    210                 215                 220                 
Asn Thr Ala Ile Gln Ala Trp Gln Gln Asn Lys Cys Pro Glu Val Glu
225                 230                 235                 240 
Glu Leu Val Phe Ser His Phe Val Ile Cys Asn Asp Thr Gln Glu Thr
                245                 250                 255     
Leu Arg Phe Gly Gln Val Asp Thr Asp Glu Asn Ile Leu Leu Ala Ser
            260                 265                 270         
Leu His Ser His Gln Tyr Ser Trp Arg Ser His Lys Ser Pro Gln Leu
        275                 280                 285             
Leu His Ile Cys Ile Glu Gly Trp Gly Asn Trp Arg Trp Ser Glu Pro
    290                 295                 300                 
Phe Ser Val Asp His Ala Gly Thr Phe Ile Arg Thr Ile Gln Tyr Arg
305                 310                 315                 320 
Gly Arg Thr Ala Ser Leu Ile Ile Lys Val Gln Gln Leu Asn Gly Val
                325                 330                 335     
Gln Lys Gln Ile Ile Ile Cys Gly Arg Gln Ile Ile Cys Ser Tyr Leu
            340                 345                 350         
Ser Gln Ser Ile Glu Leu Lys Val Val Gln His Tyr Ile Gly Gln Asp
        355                 360                 365             
Gly Gln Ala Val Val Arg Glu His Phe Asp Cys Leu Thr Ala Lys Gln
    370                 375                 380                 
Lys Leu Pro Ser Tyr Ile Leu Glu Asn Asn Glu Leu Thr Glu Leu Cys
385                 390                 395                 400 
Val Lys Ala Lys Gly Asp Glu Asp Trp Ser Arg Asp Val Cys Leu Glu
                405                 410                 415     
Ser Lys Ala Pro Glu Tyr Ser Ile Val Ile Gln Val Pro Ser Ser Asn
            420                 425                 430         
Ser Ser Ile Ile Tyr Val Trp Cys Thr Val Leu Thr Leu Glu Pro Asn
        435                 440                 445             
Ser Gln Val Gln Gln Arg Met Ile Val Phe Ser Pro Leu Phe Ile Met
    450                 455                 460                 
Arg Ser His Leu Pro Asp Pro Ile Ile Ile His Leu Glu Lys Arg Ser
465                 470                 475                 480 
Leu Gly Leu Ser Glu Thr Gln Ile Ile Pro Gly Lys Gly Gln Glu Lys
                485                 490                 495     
Pro Leu Gln Asn Ile Glu Pro Asp Leu Val His His Leu Thr Phe Gln
            500                 505                 510         
Ala Arg Glu Glu Tyr Asp Pro Ser Asp Cys Ala Val Pro Ile Ser Thr
        515                 520                 525             
Ser Leu Ile Lys Gln Ile Ala Thr Lys Val His Pro Gly Gly Thr Val
    530                 535                 540                 
Asn Gln Ile Leu Asp Glu Phe Tyr Gly Pro Glu Lys Ser Leu Gln Pro
545                 550                 555                 560 
Ile Trp Pro Tyr Asn Lys Lys Asp Ser Asp Arg Asn Glu Gln Leu Ser
                565                 570                 575     
Gln Trp Asp Ser Pro Met Arg Val Lys Leu Ser Ile Trp Lys Pro Tyr
            580                 585                 590         
Val Arg Thr Leu Leu Ile Glu Leu Leu Pro Trp Ala Leu Leu Ile Asn
        595                 600                 605             
Glu Ser Lys Trp Asp Leu Trp Leu Phe Glu Gly Glu Lys Ile Val Leu
    610                 615                 620                 
Gln Val Pro Ala Gly Lys Ile Ile Ile Pro Pro Asn Phe Gln Glu Ala
625                 630                 635                 640 
Phe Gln Ile Gly Ile Tyr Trp Ala Asn Thr Asn Thr Val His Lys Ser
                645                 650                 655     
Val Ala Ile Lys Leu Val His Asn Leu Thr Ser Pro Lys Trp Lys Asp
            660                 665                 670         
Gly Gly Asn Gly Glu Val Val Thr Leu Asp Glu Glu Ala Phe Val Asp
        675                 680                 685             
Thr Glu Ile Arg Leu Gly Ala Phe Pro Gly His Gln Lys Leu Cys Gln
    690                 695                 700                 
Phe Cys Ile Ser Ser Met Val Gln Gln Gly Ile Gln Ile Ile Gln Ile
705                 710                 715                 720 
Glu Asp Lys Thr Thr Ile Ile Asn Asn Thr Pro Tyr Gln Ile Phe Tyr
                725                 730                 735     
Lys Pro Gln Leu Ser Val Cys Asn Pro His Ser Gly Lys Glu Tyr Phe
            740                 745                 750         
Arg Val Pro Asp Ser Ala Thr Phe Ser Ile Cys Pro Gly Gly Glu Gln
        755                 760                 765             
Pro Ala Met Lys Ser Ser Ser Leu Pro Cys Trp Asp Leu Met Pro Asp
    770                 775                 780                 
Ile Ser Gln Ser Val Leu Asp Ala Ser Leu Leu Gln Lys Gln Ile Met
785                 790                 795                 800 
Leu Gly Phe Ser Pro Ala Pro Gly Ala Asp Ser Ser Gln Cys Trp Ser
                805                 810                 815     
Leu Pro Ala Ile Val Arg Pro Glu Phe Pro Arg Gln Ser Val Ala Val
            820                 825                 830         
Pro Leu Gly Asn Phe Arg Glu Asn Gly Phe Cys Thr Arg Ala Ile Val
        835                 840                 845             
Leu Thr Tyr Gln Glu His Leu Gly Val Thr Tyr Leu Thr Leu Ser Glu
    850                 855                 860                 
Asp Pro Ser Pro Arg Val Ile Ile His Asn Arg Cys Pro Val Lys Met
865                 870                 875                 880 
Leu Ile Lys Glu Asn Ile Lys Asp Ile Pro Lys Phe Glu Val Tyr Cys
                885                 890                 895     
Lys Lys Ile Pro Ser Glu Cys Ser Ile His His Glu Leu Tyr His Gln
            900                 905                 910         
Ile Ser Ser Tyr Pro Asp Cys Lys Thr Lys Asp Leu Leu Pro Ser Leu
        915                 920                 925             
Leu Leu Arg Val Glu Pro Leu Asp Glu Val Thr Thr Glu Trp Ser Asp
    930                 935                 940                 
Ala Ile Asp Ile Asn Ser Gln Gly Thr Gln Val Val Phe Leu Thr Gly
945                 950                 955                 960 
Phe Gly Tyr Val Tyr Val Asp Val Val His Gln Cys Gly Thr Val Phe
                965                 970                 975     
Ile Thr Val Ala Pro Glu Gly Lys Ala Gly Pro Ile Leu Thr Asn Thr
            980                 985                 990         
Asn Arg Ala Pro Glu Lys Ile Val Thr Phe Lys Met Phe Ile Thr Gln
        995                 1000                1005            
Leu Ser Leu Ala Val Phe Asp Asp Leu Thr His His Lys Ala Ser Ala
    1010                1015                1020                
Glu Leu Leu Arg Leu Thr Leu Asp Asn Ile Phe Leu Cys Val Ala Pro
1025                1030                1035                1040
Gly Ala Gly Pro Leu Pro Gly Glu Glu Pro Val Ala Ala Leu Phe Glu
                1045                1050                1055    
Leu Tyr Cys Val Glu Ile Cys Cys Gly Asp Leu Gln Leu Asp Asn Gln
            1060                1065                1070        
Leu Tyr Asn Lys Ser Asn Phe His Phe Ala Val Leu Val Cys Gln Gly
        1075                1080                1085            
Glu Lys Ala Glu Pro Ile Gln Cys Ser Lys Met Gln Ser Leu Leu Ile
    1090                1095                1100                
Ser Asn Lys Glu Leu Glu Glu Tyr Lys Glu Lys Cys Phe Ile Lys Leu
1105                1110                1115                1120
Cys Ile Thr Leu Asn Glu Gly Lys Ser Ile Leu Cys Asp Ile Asn Glu
                1125                1130                1135    
Phe Ser Phe Glu Leu Lys Pro Ala Arg Leu Tyr Val Glu Asp Thr Phe
            1140                1145                1150        
Val Tyr Tyr Ile Lys Thr Leu Phe Asp Thr Tyr Leu Pro Asn Ser Arg
        1155                1160                1165            
Leu Ala Gly His Ser Thr His Leu Ser Gly Gly Lys Gln Val Leu Pro
    1170                1175                1180                
Met Gln Val Thr Gln His Ala Arg Ala Leu Val Asn Pro Val Lys Leu
1185                1190                1195                1200
Arg Lys Leu Val Ile Gln Pro Val Asn Leu Leu Val Ser Ile His Ala
                1205                1210                1215    
Ser Leu Lys Leu Tyr Ile Ala Ser Asp His Thr Pro Leu Ser Phe Ser
            1220                1225                1230        
Val Phe Glu Arg Gly Pro Ile Phe Thr Thr Ala Arg Gln Leu Val His
        1235                1240                1245            
Ala Leu Ala Met His Tyr Ala Ala Gly Ala Leu Phe Arg Ala Gly Trp
    1250                1255                1260                
Val Val Gly Ser Leu Asp Ile Leu Gly Ser Pro Ala Ser Leu Val Arg
1265                1270                1275                1280
Ser Ile Gly Asn Gly Val Ala Asp Phe Phe Arg Leu Pro Tyr Glu Gly
                1285                1290                1295    
Leu Thr Arg Gly Pro Gly Ala Phe Val Ser Gly Val Ser Arg Gly Thr
            1300                1305                1310        
Thr Ser Phe Val Lys His Ile Ser Lys Gly Thr Leu Thr Ser Ile Thr
        1315                1320                1325            
Asn Leu Ala Thr Ser Leu Ala Arg Asn Met Asp Arg Leu Ser Leu Asp
    1330                1335                1340                
Glu Glu His Tyr Asn Arg Gln Glu Glu Trp Arg Arg Gln Leu Pro Glu
1345                1350                1355                1360
Ser Leu Gly Glu Gly Leu Arg Gln Gly Leu Ser Arg Leu Gly Ile Ser
                1365                1370                1375    
Leu Leu Gly Ala Ile Ala Gly Ile Val Asp Gln Pro Met Gln Asn Phe
            1380                1385                1390        
Gln Lys Thr Ser Glu Ala Gln Ala Ser Ala Gly His Lys Ala Lys Gly
        1395                1400                1405            
Val Ile Ser Gly Val Gly Lys Gly Ile Met Gly Val Phe Thr Lys Pro
    1410                1415                1420                
Ile Gly Gly Ala Ala Glu Leu Val Ser Gln Thr Gly Tyr Gly Ile Leu
1425                1430                1435                1440
His Gly Ala Gly Leu Ser Gln Leu Pro Lys Gln Arg His Gln Pro Ser
                1445                1450                1455    
Asp Leu His Ala Asp Gln Ala Pro Asn Ser His Val Lys Tyr Val Trp
            1460                1465                1470        
Lys Met Leu Gln Ser Leu Gly Arg Pro Glu Val His Met Ala Leu Asp
        1475                1480                1485            
Val Val Leu Val Arg Gly Ser Gly Gln Glu His Glu Gly Cys Leu Leu
    1490                1495                1500                
Leu Thr Ser Glu Val Leu Phe Val Val Ser Val Ser Glu Asp Thr Gln
1505                1510                1515                1520
Gln Gln Ala Phe Pro Val Thr Glu Ile Asp Cys Ala Gln Asp Ser Lys
                1525                1530                1535    
Gln Asn Asn Leu Leu Thr Val Gln Leu Lys Gln Pro Arg Val Ala Cys
            1540                1545                1550        
Asp Val Glu Val Asp Gly Val Arg Glu Arg Leu Ser Glu Gln Gln Tyr
        1555                1560                1565            
Asn Arg Leu Val Asp Tyr Ile Thr Lys Thr Ser Cys His Leu Ala Pro
    1570                1575                1580                
Ser Cys Ser Ser Met Gln Ile Pro Cys Pro Val Val Ala Ala Glu Pro
1585                1590                1595                1600
Pro Pro Ser Thr Val Lys Thr Tyr His Tyr Leu Val Asp Pro His Phe
                1605                1610                1615    
Ala Gln Val Phe Leu Ser Lys Phe Thr Met Val Lys Asn Lys Ala Leu
            1620                1625                1630        
Arg Lys Gly Phe Pro
        1635        


<210> 824
<211> 1441
<212> PRT
<213> Homo sapiens

<400> 824
Gly Tyr Asn Ile Glu Pro Ile Met Leu Tyr Gln Asp Met Thr Ala Arg
 1               5                  10                  15      
Asp Leu Leu Gln Gln Arg Tyr Thr Leu Pro Asn Gly Asp Thr Ala Trp
            20                  25                  30          
Arg Ser Ser Pro Leu Val Asn Ala Ala Leu Glu Gly Lys Leu Val Leu
        35                  40                  45              
Leu Asp Gly Ile His Arg Val Asn Ala Gly Thr Leu Ala Val Leu Gln
    50                  55                  60                  
Arg Leu Ile His Asp Arg Glu Leu Ser Leu Tyr Asp Gly Ser Arg Leu
65                  70                  75                  80  
Leu Arg Glu Asp Arg Tyr Met Arg Leu Lys Glu Glu Leu Gln Leu Ser
                85                  90                  95      
Asp Glu Gln Leu Gln Lys Arg Ser Ile Phe Pro Ile His Pro Ser Phe
            100                 105                 110         
Arg Ile Ile Ala Leu Ala Glu Pro Pro Val Ile Gly Ser Thr Ala His
        115                 120                 125             
Gln Trp Leu Gly Pro Glu Phe Leu Thr Met Phe Phe Phe His Tyr Met
    130                 135                 140                 
Lys Pro Leu Val Lys Ser Glu Glu Ile Gln Val Ile Lys Glu Lys Val
145                 150                 155                 160 
Pro Asn Val Pro Gln Glu Ala Leu Asp Lys Leu Leu Ser Phe Thr His
                165                 170                 175     
Lys Leu Arg Glu Thr Gln Asp Pro Thr Ala Gln Ser Leu Ala Ala Ser
            180                 185                 190         
Leu Ser Thr Arg Gln Leu Leu Arg Ile Ser Arg Arg Leu Ser Gln Tyr
        195                 200                 205             
Pro Asn Glu Asn Leu His Ser Ala Val Thr Lys Ala Cys Leu Ser Arg
    210                 215                 220                 
Phe Leu Pro Ser Leu Ala Arg Ser Ala Leu Glu Lys Asn Leu Ala Asp
225                 230                 235                 240 
Ala Thr Ile Glu Ile Asn Thr Asp Asp Asn Leu Glu Pro Glu Leu Lys
                245                 250                 255     
Asp Tyr Lys Cys Glu Val Thr Ser Gly Thr Leu Arg Ile Gly Ala Val
            260                 265                 270         
Ser Ala Pro Ile Tyr Asn Ala His Glu Lys Met Lys Val Pro Asp Val
        275                 280                 285             
Leu Phe Tyr Asp Asn Ile Gln His Val Ile Val Met Glu Asp Met Leu
    290                 295                 300                 
Lys Asp Phe Leu Leu Gly Glu His Leu Leu Leu Val Gly Asn Gln Gly
305                 310                 315                 320 
Val Gly Lys Asn Lys Ile Val Asp Arg Phe Leu His Leu Leu Asn Arg
                325                 330                 335     
Pro Arg Glu Tyr Ile Gln Leu His Arg Asp Thr Thr Val Gln Thr Leu
            340                 345                 350         
Thr Leu Gln Pro Ser Val Lys Asp Gly Leu Ile Val Tyr Glu Asp Ser
        355                 360                 365             
Pro Leu Val Lys Ala Val Lys Leu Gly His Ile Leu Val Val Asp Glu
    370                 375                 380                 
Ala Asp Lys Ala Pro Thr Asn Val Thr Cys Ile Leu Lys Thr Leu Val
385                 390                 395                 400 
Glu Asn Gly Glu Met Ile Leu Ala Asp Gly Arg Arg Ile Val Ala Asn
                405                 410                 415     
Ser Ala Asn Val Asn Gly Arg Glu Asn Val Val Val Ile His Pro Asp
            420                 425                 430         
Phe Arg Met Ile Val Leu Ala Asn Arg Pro Gly Phe Pro Phe Leu Gly
        435                 440                 445             
Asn Asp Phe Phe Gly Thr Leu Gly Asp Ile Phe Ser Cys His Ala Val
    450                 455                 460                 
Asp Asn Pro Lys Pro His Ser Glu Leu Glu Met Leu Arg Gln Tyr Gly
465                 470                 475                 480 
Pro Asn Val Pro Glu Pro Ile Leu Gln Lys Leu Val Ala Ala Phe Gly
                485                 490                 495     
Glu Leu Arg Ser Leu Ala Asp Gln Gly Ile Ile Asn Tyr Pro Tyr Ser
            500                 505                 510         
Thr Arg Glu Val Val Asn Ile Val Lys His Leu Gln Lys Phe Pro Thr
        515                 520                 525             
Glu Gly Leu Ser Ser Val Val Arg Asn Val Phe Asp Phe Asp Ser Tyr
    530                 535                 540                 
Asn Asn Asp Met Arg Glu Ile Leu Ile Asn Thr Leu His Lys Tyr Gly
545                 550                 555                 560 
Ile Pro Ile Gly Ala Lys Pro Thr Ser Val Gln Leu Ala Lys Glu Leu
                565                 570                 575     
Thr Leu Pro Glu Gln Thr Phe Met Gly Tyr Trp Thr Ile Gly Gln Ala
            580                 585                 590         
Arg Ser Gly Met Gln Lys Leu Leu Cys Pro Val Glu Thr His His Ile
        595                 600                 605             
Asp Ile Lys Gly Pro Ala Leu Ile Asn Ile Gln Glu Tyr Pro Ile Glu
    610                 615                 620                 
Arg His Glu Glu Arg Ser Leu Asn Phe Thr Glu Glu Cys Ala Ser Trp
625                 630                 635                 640 
Arg Ile Pro Leu Asp Glu Ile Asn Ile Ile Cys Asp Ile Ala Thr Ser
                645                 650                 655     
His Glu Asn Glu Gln Asn Thr Leu Tyr Val Val Thr Cys Asn Pro Ala
            660                 665                 670         
Ser Leu Tyr Phe Met Asn Met Thr Gly Lys Ser Gly Phe Phe Val Asp
        675                 680                 685             
Phe Phe Asp Ile Phe Pro Arg Thr Ala Asn Gly Val Trp His Pro Phe
    690                 695                 700                 
Val Thr Val Ala Pro Leu Gly Ser Pro Leu Lys Gly Gln Val Val Leu
705                 710                 715                 720 
His Glu Gln Gln Ser Asn Val Ile Leu Leu Leu Asp Thr Thr Gly Arg
                725                 730                 735     
Ala Leu His Arg Leu Ile Leu Pro Ser Glu Lys Phe Thr Ser Lys Lys
            740                 745                 750         
Pro Phe Trp Trp Asn Lys Glu Glu Ala Glu Thr Tyr Lys Met Cys Lys
        755                 760                 765             
Glu Phe Ser His Lys Asn Trp Leu Val Phe Tyr Lys Glu Lys Gly Asn
    770                 775                 780                 
Ser Leu Thr Val Leu Asp Val Leu Glu Gly Arg Thr His Thr Ile Ser
785                 790                 795                 800 
Leu Pro Ile Asn Leu Lys Thr Val Phe Leu Val Ala Glu Asp Lys Trp
                805                 810                 815     
Leu Leu Val Glu Ser Lys Thr Asn Gln Lys Tyr Leu Leu Thr Lys Pro
            820                 825                 830         
Ala His Ile Glu Ser Glu Gly Ser Gly Val Cys Gln Leu Tyr Val Leu
        835                 840                 845             
Lys Glu Glu Pro Pro Ser Thr Gly Phe Gly Val Thr Gln Glu Thr Glu
    850                 855                 860                 
Phe Ser Ile Pro His Lys Ile Ser Ser Asp Gln Leu Ser Ser Glu His
865                 870                 875                 880 
Leu Ser Ser Ala Val Glu Gln Lys Ile Ala Ser Pro Asn Arg Ile Leu
                885                 890                 895     
Ser Asp Glu Lys Asn Tyr Ala Thr Ile Val Val Gly Phe Pro Asp Leu
            900                 905                 910         
Met Ser Pro Ser Glu Val Tyr Ser Trp Lys Arg Pro Ser Ser Leu His
        915                 920                 925             
Lys Arg Ser Gly Thr Asp Thr Ser Phe Tyr Arg Gly Lys Lys Lys Arg
    930                 935                 940                 
Gly Thr Pro Lys Gln Ser Asn Cys Val Thr Leu Leu Asp Thr Asn Gln
945                 950                 955                 960 
Val Val Arg Ile Leu Pro Pro Gly Glu Val Pro Leu Lys Asp Ile Tyr
                965                 970                 975     
Pro Lys Asp Val Thr Pro Pro Gln Thr Ser Gly Tyr Ile Glu Val Thr
            980                 985                 990         
Asp Leu Gln Ser Lys Lys Leu Arg Tyr Ile Pro Ile Pro Arg Ser Glu
        995                 1000                1005            
Ser Leu Ser Pro Tyr Thr Thr Trp Leu Ser Thr Ile Ser Asp Thr Asp
    1010                1015                1020                
Ala Leu Leu Ala Glu Trp Asp Lys Ser Gly Val Val Thr Val Asp Met
1025                1030                1035                1040
Gly Gly His Ile Arg Leu Trp Glu Thr Gly Leu Glu Arg Leu Gln Arg
                1045                1050                1055    
Ser Leu Met Glu Trp Arg Asn Met Ile Gly Gln Asp Asp Arg Asn Met
            1060                1065                1070        
Gln Ile Thr Ile Asn Arg Asp Ser Gly Glu Asp Val Ser Ser Pro Lys
        1075                1080                1085            
His Gly Lys Glu Asp Pro Asp Asn Met Pro His Val Gly Gly Asn Thr
    1090                1095                1100                
Trp Ala Gly Gly Thr Gly Gly Arg Asp Thr Ala Gly Leu Gly Gly Lys
1105                1110                1115                1120
Gly Gly Pro Tyr Arg Leu Asp Ala Gly His Thr Val Tyr Gln Val Ser
                1125                1130                1135    
Gln Ala Glu Lys Asp Ala Val Pro Glu Glu Val Lys Arg Ala Ala Arg
            1140                1145                1150        
Glu Met Gly Gln Arg Ala Phe Gln Gln Arg Leu Lys Glu Ile Gln Met
        1155                1160                1165            
Ser Glu Tyr Asp Ala Ala Thr Tyr Glu Arg Phe Ser Gly Ala Val Arg
    1170                1175                1180                
Arg Gln Val His Ser Leu Arg Ile Ile Leu Asp Asn Leu Gln Ala Lys
1185                1190                1195                1200
Gly Lys Glu Arg Gln Trp Leu Arg His Gln Ala Thr Gly Glu Leu Asp
                1205                1210                1215    
Asp Ala Lys Ile Ile Asp Gly Leu Thr Gly Glu Lys Ala Ile Tyr Lys
            1220                1225                1230        
Arg Arg Gly Glu Leu Glu Pro Gln Leu Gly Ser Pro Gln Gln Lys Pro
        1235                1240                1245            
Lys Arg Leu Arg Leu Val Val Asp Val Ser Gly Ser Met Tyr Arg Phe
    1250                1255                1260                
Asn Arg Met Asp Gly Arg Leu Glu Arg Thr Met Glu Ala Val Cys Met
1265                1270                1275                1280
Val Met Glu Ala Phe Glu Asn Tyr Glu Glu Lys Phe Gln Tyr Asp Ile
                1285                1290                1295    
Val Gly His Ser Gly Asp Gly Tyr Asn Ile Gly Leu Val Pro Met Asn
            1300                1305                1310        
Lys Ile Pro Lys Asp Asn Lys Gln Arg Leu Glu Ile Leu Lys Thr Met
        1315                1320                1325            
His Ala His Ser Gln Phe Cys Met Ser Gly Asp His Thr Leu Glu Gly
    1330                1335                1340                
Thr Glu His Ala Ile Lys Glu Ile Val Lys Glu Glu Ala Asp Glu Tyr
1345                1350                1355                1360
Phe Val Ile Val Leu Ser Asp Ala Asn Leu Ser Arg Tyr Gly Ile His
                1365                1370                1375    
Pro Ala Lys Phe Ala Gln Ile Leu Thr Arg Asp Pro Gln Val Asn Ala
            1380                1385                1390        
Phe Ala Ile Phe Ile Gly Ser Leu Gly Asp Gln Ala Thr Arg Leu Gln
        1395                1400                1405            
Arg Thr Leu Pro Ala Gly Arg Ser Phe Val Ala Met Asp Thr Lys Asp
    1410                1415                1420                
Ile Pro Gln Ile Leu Gln Gln Ile Phe Thr Ser Thr Met Leu Ser Ser
1425                1430                1435                1440
Val
    


<210> 825
<211> 978
<212> PRT
<213> Homo sapiens

<400> 825
Thr Gly Ala Pro Ala Trp Pro Ser Arg Arg Leu Arg Asp Leu Pro Ala
 1               5                  10                  15      
Gly Gly Met Trp Arg Leu Arg Arg Ala Ala Val Ala Cys Glu Val Cys
            20                  25                  30          
Gln Ser Leu Val Lys His Ser Ser Gly Ile Lys Gly Ser Leu Pro Leu
        35                  40                  45              
Gln Lys Leu His Leu Val Ser Arg Ser Ile Tyr His Ser His His Pro
    50                  55                  60                  
Thr Leu Lys Leu Gln Arg Pro Gln Leu Arg Thr Ser Phe Gln Gln Phe
65                  70                  75                  80  
Ser Ser Leu Thr Asn Leu Pro Leu Arg Lys Leu Lys Phe Ser Pro Ile
                85                  90                  95      
Lys Tyr Gly Tyr Gln Pro Arg Arg Asn Phe Trp Pro Ala Arg Leu Ala
            100                 105                 110         
Thr Arg Leu Leu Lys Leu Arg Tyr Leu Ile Leu Gly Ser Ala Val Gly
        115                 120                 125             
Gly Gly Tyr Thr Ala Lys Lys Thr Phe Asp Gln Trp Lys Asp Met Ile
    130                 135                 140                 
Pro Asp Leu Ser Glu Tyr Lys Trp Ile Val Pro Asp Ile Val Trp Glu
145                 150                 155                 160 
Ile Asp Glu Tyr Ile Asp Phe Glu Lys Ile Arg Lys Ala Leu Pro Asn
                165                 170                 175     
Ser Glu Asp Leu Val Lys Leu Ala Pro Asp Phe Asp Lys Ile Val Glu
            180                 185                 190         
Ser Leu Ser Leu Leu Lys Asp Phe Phe Thr Ser Gly Ser Pro Glu Glu
        195                 200                 205             
Thr Ala Phe Arg Ala Thr Asp Arg Gly Ser Glu Ser Asp Lys His Phe
    210                 215                 220                 
Arg Lys Val Ser Asp Lys Glu Lys Ile Asp Gln Leu Gln Glu Glu Leu
225                 230                 235                 240 
Leu His Thr Gln Leu Lys Tyr Gln Arg Ile Leu Glu Arg Leu Glu Lys
                245                 250                 255     
Glu Asn Lys Glu Leu Arg Lys Leu Val Leu Gln Lys Asp Asp Lys Gly
            260                 265                 270         
Ile His His Arg Lys Leu Lys Lys Ser Leu Ile Asp Met Tyr Ser Glu
        275                 280                 285             
Val Leu Asp Val Leu Ser Asp Tyr Asp Ala Ser Tyr Asn Thr Gln Asp
    290                 295                 300                 
His Leu Pro Arg Val Val Val Val Gly Asp Gln Ser Ala Gly Lys Thr
305                 310                 315                 320 
Ser Val Leu Glu Met Ile Ala Gln Ala Arg Ile Phe Pro Arg Gly Ser
                325                 330                 335     
Gly Glu Met Met Thr Arg Ser Pro Val Lys Val Thr Leu Ser Glu Gly
            340                 345                 350         
Pro His His Val Ala Leu Phe Lys Asp Ser Ser Arg Glu Phe Asp Leu
        355                 360                 365             
Thr Lys Glu Glu Asp Leu Ala Ala Leu Arg His Glu Ile Glu Leu Arg
    370                 375                 380                 
Met Arg Lys Asn Val Lys Glu Gly Cys Thr Val Ser Pro Glu Thr Ile
385                 390                 395                 400 
Ser Leu Asn Val Lys Gly Pro Gly Leu Gln Arg Met Val Leu Val Asp
                405                 410                 415     
Leu Pro Gly Val Ile Asn Thr Val Thr Ser Gly Met Ala Pro Asp Thr
            420                 425                 430         
Lys Glu Thr Ile Phe Ser Ile Ser Lys Ala Tyr Met Gln Asn Pro Asn
        435                 440                 445             
Ala Ile Ile Leu Cys Ile Gln Asp Gly Ser Val Asp Ala Glu Arg Ser
    450                 455                 460                 
Ile Val Thr Asp Leu Val Ser Gln Met Asp Pro His Gly Arg Arg Thr
465                 470                 475                 480 
Ile Phe Val Leu Thr Lys Val Asp Leu Ala Glu Lys Asn Val Ala Ser
                485                 490                 495     
Pro Ser Arg Ile Gln Gln Ile Ile Glu Gly Lys Leu Phe Pro Met Lys
            500                 505                 510         
Ala Leu Gly Tyr Phe Ala Val Val Thr Gly Lys Gly Asn Ser Ser Glu
        515                 520                 525             
Ser Ile Glu Ala Ile Arg Glu Tyr Glu Glu Glu Phe Phe Gln Asn Ser
    530                 535                 540                 
Lys Leu Leu Lys Thr Ser Met Leu Lys Ala His Gln Val Thr Thr Arg
545                 550                 555                 560 
Asn Leu Ser Leu Ala Val Ser Asp Cys Phe Trp Lys Met Val Arg Glu
                565                 570                 575     
Ser Val Glu Gln Gln Ala Asp Ser Phe Lys Ala Thr Arg Phe Asn Leu
            580                 585                 590         
Glu Thr Glu Trp Lys Asn Asn Tyr Pro Arg Leu Arg Glu Leu Asp Arg
        595                 600                 605             
Asn Glu Leu Phe Glu Lys Ala Lys Asn Glu Ile Leu Asp Glu Val Ile
    610                 615                 620                 
Ser Leu Ser Gln Val Thr Pro Lys His Trp Glu Glu Ile Leu Gln Gln
625                 630                 635                 640 
Ser Leu Trp Glu Arg Val Ser Thr His Val Ile Glu Asn Ile Tyr Leu
                645                 650                 655     
Pro Ala Ala Gln Thr Met Asn Ser Gly Thr Phe Asn Thr Thr Val Asp
            660                 665                 670         
Ile Lys Leu Lys Gln Trp Thr Asp Lys Gln Leu Pro Asn Lys Ala Val
        675                 680                 685             
Glu Val Ala Trp Glu Thr Leu Gln Glu Glu Phe Ser Arg Phe Met Thr
    690                 695                 700                 
Glu Pro Lys Gly Lys Glu His Asp Asp Ile Phe Asp Lys Leu Lys Glu
705                 710                 715                 720 
Ala Val Lys Glu Glu Ser Ile Lys Arg His Lys Trp Asn Asp Phe Ala
                725                 730                 735     
Glu Asp Ser Leu Arg Val Ile Gln His Asn Ala Leu Glu Asp Arg Ser
            740                 745                 750         
Ile Ser Asp Lys Gln Gln Trp Asp Ala Ala Ile Tyr Phe Met Glu Glu
        755                 760                 765             
Ala Leu Gln Ala Arg Leu Lys Asp Thr Glu Asn Ala Ile Glu Asn Met
    770                 775                 780                 
Val Gly Pro Asp Trp Lys Lys Arg Trp Leu Tyr Trp Lys Asn Arg Thr
785                 790                 795                 800 
Gln Glu Gln Cys Val His Asn Glu Thr Lys Asn Glu Leu Glu Lys Met
                805                 810                 815     
Leu Lys Cys Asn Glu Glu His Pro Ala Tyr Leu Ala Ser Asp Glu Ile
            820                 825                 830         
Thr Thr Val Arg Lys Asn Leu Glu Ser Arg Gly Val Glu Val Asp Pro
        835                 840                 845             
Ser Leu Ile Lys Asp Thr Trp His Gln Val Tyr Arg Arg His Phe Leu
    850                 855                 860                 
Lys Thr Ala Leu Asn His Cys Asn Leu Cys Arg Arg Gly Phe Tyr Tyr
865                 870                 875                 880 
Tyr Gln Arg His Phe Val Asp Ser Glu Leu Glu Cys Asn Asp Val Val
                885                 890                 895     
Leu Phe Trp Arg Ile Gln Arg Met Leu Ala Ile Thr Ala Asn Thr Leu
            900                 905                 910         
Arg Gln Gln Leu Thr Asn Thr Glu Val Arg Arg Leu Glu Lys Asn Val
        915                 920                 925             
Lys Glu Val Leu Glu Asp Phe Ala Glu Asp Gly Glu Lys Lys Ile Lys
    930                 935                 940                 
Leu Leu Thr Gly Lys Arg Val Gln Leu Ala Glu Asp Leu Lys Lys Val
945                 950                 955                 960 
Arg Glu Ile Gln Glu Lys Leu Asp Ala Phe Ile Glu Ala Leu His Gln
                965                 970                 975     
Glu Lys
        


<210> 826
<211> 357
<212> PRT
<213> Homo sapiens

<400> 826
Met Arg Gly Ser Leu Leu Ala Ser Gly Arg Ala Pro Arg Arg Ala Ser
 1               5                  10                  15      
Ser Gly Leu Pro Arg Asn Thr Val Val Leu Phe Val Pro Gln Gln Glu
            20                  25                  30          
Ala Trp Val Val Glu Arg Met Gly Arg Phe His Arg Ile Leu Glu Pro
        35                  40                  45              
Gly Leu Asn Ile Leu Ile Pro Val Leu Asp Arg Ile Arg Tyr Val Gln
    50                  55                  60                  
Ser Leu Lys Glu Ile Val Ile Asn Val Pro Glu Gln Ser Ala Val Thr
65                  70                  75                  80  
Leu Asp Asn Val Thr Leu Gln Ile Asp Gly Val Leu Tyr Leu Arg Ile
                85                  90                  95      
Met Asp Pro Tyr Lys Ala Ser Tyr Gly Val Glu Asp Pro Glu Tyr Ala
            100                 105                 110         
Val Thr Gln Leu Ala Gln Thr Thr Met Arg Ser Glu Leu Gly Lys Leu
        115                 120                 125             
Ser Leu Asp Lys Val Phe Arg Glu Arg Glu Ser Leu Asn Ala Ser Ile
    130                 135                 140                 
Val Asp Ala Ile Asn Gln Ala Ala Asp Cys Trp Gly Ile Arg Cys Leu
145                 150                 155                 160 
Arg Tyr Glu Ile Lys Asp Ile His Val Pro Pro Arg Val Lys Glu Ser
                165                 170                 175     
Met Gln Met Gln Val Gly Ala Lys Glu Gly Trp Glu Lys Gly Leu Arg
            180                 185                 190         
Ala Pro Val Glu Ala Glu Arg Arg Lys Arg Ala Thr Val Leu Glu Ser
        195                 200                 205             
Glu Gly Thr Arg Glu Ser Ala Ile Asn Val Ala Glu Gly Lys Lys Gln
    210                 215                 220                 
Ala Gln Ile Leu Ala Ser Glu Ala Glu Lys Ala Glu Gln Ile Asn Gln
225                 230                 235                 240 
Ala Ala Gly Glu Ala Ser Ala Val Leu Ala Lys Ala Lys Ala Lys Ala
                245                 250                 255     
Glu Ala Ile Arg Ile Leu Ala Ala Ala Leu Thr Gln His Asn Gly Asp
            260                 265                 270         
Ala Ala Ala Ser Leu Thr Val Ala Glu Gln Tyr Val Ser Ala Phe Ser
        275                 280                 285             
Lys Leu Ala Lys Asp Ser Asn Thr Ile Leu Leu Pro Ser Asn Pro Gly
    290                 295                 300                 
Asp Val Thr Ser Met Val Ala Gln Ala Met Gly Val Tyr Gly Ala Leu
305                 310                 315                 320 
Thr Lys Ala Pro Val Pro Gly Thr Pro Asp Ser Leu Ser Ser Gly Ser
                325                 330                 335     
Ser Arg Asp Val Gln Gly Thr Asp Ala Ser Leu Asp Glu Glu Leu Asp
            340                 345                 350         
Arg Val Lys Met Ser
        355         


<210> 827
<211> 903
<212> PRT
<213> Homo sapiens

<400> 827
Met Pro Pro Thr Glu Asp Arg Ser Trp Trp Arg Gly Lys Arg Gly Phe
 1               5                  10                  15      
Gln Leu Cys His Gly Leu Val Gly Ser Trp Pro Ala Cys Ser Ala Pro
            20                  25                  30          
Ser Cys Ala Pro Ala Leu Leu Gly Ser Gly Cys Gly Ser Gly Glu Ser
        35                  40                  45              
Cys Asp Arg Gly Cys Leu Ala Ala Ile Leu Ala Ser Thr Ser Ala Thr
    50                  55                  60                  
Gln Ala Arg Met Val Leu Arg Cys Cys Ser Glu Phe Ile Glu Ala His
65                  70                  75                  80  
Gly Val Val Asp Gly Ile Tyr Arg Leu Ser Gly Val Ser Ser Asn Ile
                85                  90                  95      
Gln Arg Leu Arg His Glu Phe Asp Ser Glu Arg Ile Pro Glu Leu Ser
            100                 105                 110         
Gly Pro Ala Phe Leu Gln Asp Ile His Ser Val Ser Ser Leu Cys Lys
        115                 120                 125             
Leu Tyr Phe Arg Glu Leu Pro Asn Pro Leu Leu Thr Tyr Gln Leu Tyr
    130                 135                 140                 
Gly Lys Phe Ser Glu Ala Met Ser Val Pro Gly Glu Glu Glu Arg Leu
145                 150                 155                 160 
Val Arg Val His Asp Val Ile Gln Gln Leu Pro Pro Pro His Tyr Arg
                165                 170                 175     
Thr Leu Glu Tyr Leu Leu Arg His Leu Ala Arg Met Ala Arg His Ser
            180                 185                 190         
Ala Asn Thr Ser Met His Ala Arg Asn Leu Ala Ile Val Trp Ala Pro
        195                 200                 205             
Asn Leu Leu Arg Ser Met Glu Leu Glu Ser Val Gly Met Gly Gly Ala
    210                 215                 220                 
Ala Ala Phe Arg Glu Val Arg Val Gln Ser Val Val Val Glu Phe Leu
225                 230                 235                 240 
Leu Thr His Val Asp Val Leu Phe Ser Asp Thr Phe Thr Ser Ala Gly
                245                 250                 255     
Leu Asp Pro Ala Gly Arg Cys Leu Leu Pro Arg Pro Lys Ser Leu Ala
            260                 265                 270         
Gly Ser Cys Pro Ser Thr Arg Leu Leu Thr Leu Glu Glu Ala Gln Ala
        275                 280                 285             
Arg Thr Gln Gly Arg Leu Gly Thr Pro Thr Glu Pro Thr Thr Pro Lys
    290                 295                 300                 
Ala Pro Ala Ser Pro Ala Glu Arg Arg Lys Gly Glu Arg Gly Glu Lys
305                 310                 315                 320 
Gln Arg Lys Pro Gly Gly Ser Ser Trp Lys Thr Phe Phe Ala Leu Gly
                325                 330                 335     
Arg Gly Pro Ser Val Pro Arg Lys Lys Pro Leu Pro Trp Leu Gly Gly
            340                 345                 350         
Thr Arg Ala Pro Pro Gln Pro Ser Ala Trp Leu Asp Asp Gly Asp Glu
        355                 360                 365             
Leu Asp Phe Ser Pro Pro Arg Cys Leu Glu Gly Leu Arg Gly Leu Asp
    370                 375                 380                 
Phe Asp Pro Leu Thr Phe Arg Cys Ser Ser Pro Thr Pro Gly Asp Pro
385                 390                 395                 400 
Ala Pro Pro Ala Ser Pro Ala Pro Pro Ala Pro Ala Ser Ala Phe Pro
                405                 410                 415     
Pro Arg Val Thr Pro Gln Ala Ile Ser Pro Arg Gly Pro Thr Ser Pro
            420                 425                 430         
Ala Ser Pro Ala Ala Leu Asp Ile Ser Glu Pro Leu Ala Val Ser Val
        435                 440                 445             
Pro Pro Ala Val Leu Glu Leu Leu Gly Ala Gly Gly Ala Pro Ala Ser
    450                 455                 460                 
Ala Thr Pro Thr Pro Ala Leu Ser Pro Gly Arg Ser Leu Arg Pro His
465                 470                 475                 480 
Leu Ile Pro Leu Leu Leu Arg Gly Ala Glu Ala Pro Leu Thr Asp Ala
                485                 490                 495     
Cys Gln Gln Glu Met Cys Ser Lys Leu Arg Gly Ala Gln Gly Pro Leu
            500                 505                 510         
Ala Arg Leu Met Ala Leu Ala Leu Ala Glu Arg Ala Gln Gln Val Ala
        515                 520                 525             
Glu Gln Gln Ser Gln Gln Glu Cys Gly Gly Thr Pro Pro Ala Ser Gln
    530                 535                 540                 
Ser Pro Phe His Arg Ser Leu Ser Leu Glu Val Gly Gly Glu Pro Leu
545                 550                 555                 560 
Gly Thr Ser Gly Ser Gly Pro Pro Pro Asn Ser Leu Ala His Pro Gly
                565                 570                 575     
Ala Trp Val Pro Gly Pro Pro Pro Tyr Leu Pro Arg Gln Gln Ser Asp
            580                 585                 590         
Gly Ser Leu Leu Arg Ser Gln Arg Pro Met Gly Thr Ser Arg Arg Gly
        595                 600                 605             
Leu Arg Gly Pro Ala Gln Val Ser Ala Gln Leu Arg Ala Gly Gly Gly
    610                 615                 620                 
Gly Arg Asp Ala Pro Glu Ala Ala Ala Gln Ser Pro Cys Ser Val Pro
625                 630                 635                 640 
Ser Gln Val Pro Thr Pro Gly Phe Phe Ser Pro Ala Pro Arg Glu Cys
                645                 650                 655     
Leu Pro Pro Phe Leu Gly Val Pro Lys Pro Gly Leu Tyr Pro Leu Gly
            660                 665                 670         
Pro Pro Ser Phe Gln Pro Ser Ser Pro Ala Pro Val Trp Arg Ser Ser
        675                 680                 685             
Leu Gly Pro Pro Ala Pro Leu Asp Arg Gly Glu Asn Leu Tyr Tyr Glu
    690                 695                 700                 
Ile Gly Ala Ser Glu Gly Ser Pro Tyr Ser Gly Pro Thr Arg Ser Trp
705                 710                 715                 720 
Ser Pro Phe Arg Ser Met Pro Pro Asp Arg Leu Asn Ala Ser Tyr Gly
                725                 730                 735     
Met Leu Gly Gln Ser Pro Pro Leu His Arg Ser Pro Asp Phe Leu Leu
            740                 745                 750         
Ser Tyr Pro Pro Ala Pro Ser Cys Phe Pro Pro Asp His Leu Gly Tyr
        755                 760                 765             
Ser Ala Pro Gln His Pro Ala Arg Arg Pro Thr Pro Pro Glu Pro Leu
    770                 775                 780                 
Tyr Val Asn Leu Ala Leu Gly Pro Arg Gly Pro Ser Pro Ala Ser Ser
785                 790                 795                 800 
Ser Ser Ser Ser Pro Pro Ala His Pro Arg Ser Arg Ser Asp Pro Gly
                805                 810                 815     
Pro Pro Val Pro Arg Leu Pro Gln Lys Gln Arg Ala Pro Trp Gly Pro
            820                 825                 830         
Arg Thr Pro His Arg Val Pro Gly Pro Trp Gly Pro Pro Glu Pro Leu
        835                 840                 845             
Leu Leu Tyr Arg Ala Ala Pro Pro Ala Tyr Gly Arg Gly Gly Glu Leu
    850                 855                 860                 
His Arg Gly Ser Leu Tyr Arg Asn Gly Gly Gln Arg Gly Glu Gly Ala
865                 870                 875                 880 
Gly Pro Pro Pro Pro Tyr Pro Thr Pro Ser Trp Ser Leu His Ser Glu
                885                 890                 895     
Gly Gln Thr Arg Ser Tyr Cys
            900             


<210> 828
<211> 119
<212> PRT
<213> Homo sapiens

<400> 828
Met Ile Ala Arg Arg Asn Pro Glu Pro Leu Arg Phe Leu Pro Asp Glu
 1               5                  10                  15      
Ala Arg Ser Leu Pro Pro Pro Lys Leu Thr Asp Pro Arg Leu Leu Tyr
            20                  25                  30          
Ile Gly Phe Leu Gly Tyr Cys Ser Gly Leu Ile Asp Asn Val Ile Arg
        35                  40                  45              
Arg Arg Pro Ile Ala Thr Ala Gly Leu His Arg Gln Leu Leu Tyr Ile
    50                  55                  60                  
Thr Ala Phe Phe Phe Ala Gly Tyr Tyr Leu Val Lys Arg Glu Asp Tyr
65                  70                  75                  80  
Leu Tyr Ala Val Arg Asp Arg Glu Met Phe Gly Tyr Met Lys Leu His
                85                  90                  95      
Pro Glu Asp Phe Pro Glu Glu Asp Lys Lys Thr Tyr Gly Glu Ile Phe
            100                 105                 110         
Glu Lys Phe His Pro Ile Arg
        115                 


<210> 829
<211> 161
<212> PRT
<213> Homo sapiens

<400> 829
Trp Val Gly Val Ala Met Ala Ser Arg Val Leu Ser Ala Tyr Val Ser
 1               5                  10                  15      
Arg Leu Pro Ala Ala Phe Ala Pro Leu Pro Arg Val Arg Met Leu Ala
            20                  25                  30          
Val Ala Arg Pro Leu Ser Thr Ala Leu Cys Ser Ala Gly Thr Gln Thr
        35                  40                  45              
Arg Leu Gly Thr Leu Gln Pro Ala Leu Val Leu Ala Gln Val Pro Gly
    50                  55                  60                  
Arg Val Thr Gln Leu Cys Arg Gln Tyr Ser Asp Met Pro Pro Leu Thr
65                  70                  75                  80  
Leu Glu Gly Ile Gln Asp Arg Val Leu Tyr Val Leu Lys Leu Tyr Asp
                85                  90                  95      
Lys Ile Asp Pro Glu Lys Leu Ser Val Asn Ser His Phe Met Lys Asp
            100                 105                 110         
Leu Gly Leu Asp Ser Leu Asp Gln Val Glu Ile Ile Met Ala Met Glu
        115                 120                 125             
Asp Glu Phe Gly Phe Glu Ile Pro Asp Ile Asp Ala Glu Lys Leu Met
    130                 135                 140                 
Cys Pro Gln Glu Ile Val Asp Tyr Ile Ala Asp Lys Lys Asp Val Tyr
145                 150                 155                 160 
Glu
    


<210> 830
<211> 761
<212> PRT
<213> Homo sapiens

<400> 830
Gln Thr Ser Ser Thr Gly Asn Glu Ala Gly Gly Val Asn Ser Asn Gln
 1               5                  10                  15      
Phe Glu Glu Leu Leu Gln Glu Arg Asp Lys Leu Lys Gln Gln Val Lys
            20                  25                  30          
Lys Met Glu Glu Trp Lys Gln Gln Val Met Thr Thr Val Gln Asn Met
        35                  40                  45              
Gln Arg Glu Ser Ala Gln Leu Gln Glu Glu Leu His Gln Leu Gln Ala
    50                  55                  60                  
Gln Val Leu Val Asp Ser Asp Asn Asn Ser Lys Leu Gln Val Asp Tyr
65                  70                  75                  80  
Thr Gly Leu Ile Gln Ser Tyr Glu Gln Asn Glu Thr Lys Leu Lys Asn
                85                  90                  95      
Phe Gly Gln Glu Leu Ala Gln Val Gln His Ser Ile Gly Gln Leu Cys
            100                 105                 110         
Asn Thr Lys Asp Leu Leu Leu Gly Lys Leu Asp Ile Ile Ser Pro Gln
        115                 120                 125             
Leu Ser Ser Ala Ser Leu Leu Thr Pro Gln Ser Ala Glu Cys Leu Arg
    130                 135                 140                 
Ala Ser Lys Ser Glu Val Leu Ser Glu Ser Ser Glu Leu Leu His Glu
145                 150                 155                 160 
Glu Leu Glu Glu Leu Arg Lys Ser Leu Gln Glu Lys Asp Ala Thr Ile
                165                 170                 175     
Arg Thr Leu Gln Glu Asn Asn His Arg Leu Ser Asp Ser Ile Ala Ala
            180                 185                 190         
Thr Ser Glu Leu Glu Arg Lys Glu His Glu Gln Thr Asp Ser Glu Ile
        195                 200                 205             
Lys Gln Leu Lys Glu Lys Gln Asp Val Leu Gln Lys Leu Leu Lys Glu
    210                 215                 220                 
Lys Asp Leu Leu Ile Lys Ala Lys Ser Asp Gln Leu Leu Ser Ser Asn
225                 230                 235                 240 
Glu Asn Phe Thr Asn Lys Val Asn Glu Asn Glu Leu Leu Arg Gln Ala
                245                 250                 255     
Val Thr Asn Leu Lys Glu Arg Ile Leu Ile Leu Glu Met Asp Ile Gly
            260                 265                 270         
Lys Leu Lys Gly Glu Asn Glu Lys Ile Val Glu Thr Tyr Arg Gly Lys
        275                 280                 285             
Glu Thr Glu Tyr Gln Ala Leu Gln Glu Thr Asn Met Lys Phe Ser Met
    290                 295                 300                 
Met Leu Arg Glu Lys Glu Phe Glu Cys His Ser Met Lys Glu Lys Ala
305                 310                 315                 320 
Leu Ala Phe Glu Gln Leu Leu Lys Glu Lys Glu Gln Gly Lys Thr Gly
                325                 330                 335     
Glu Leu Asn Gln Leu Leu Asn Ala Val Lys Ser Met Gln Glu Lys Thr
            340                 345                 350         
Val Val Phe Gln Gln Glu Arg Asp Gln Val Met Leu Ala Leu Lys Gln
        355                 360                 365             
Lys Gln Met Glu Asn Thr Ala Leu Gln Asn Glu Val Gln Arg Leu Arg
    370                 375                 380                 
Asp Lys Glu Phe Arg Ser Asn Gln Glu Leu Glu Arg Leu Arg Asn His
385                 390                 395                 400 
Leu Leu Glu Ser Glu Asp Ser Tyr Thr Arg Glu Ala Leu Ala Ala Glu
                405                 410                 415     
Asp Arg Glu Ala Lys Leu Arg Lys Lys Val Thr Val Leu Glu Glu Lys
            420                 425                 430         
Leu Val Ser Ser Ser Asn Ala Met Glu Asn Ala Ser His Gln Ala Ser
        435                 440                 445             
Val Gln Val Glu Ser Leu Gln Glu Gln Leu Asn Val Val Ser Lys Gln
    450                 455                 460                 
Arg Asp Glu Thr Ala Leu Gln Leu Ser Val Ser Gln Glu Gln Val Lys
465                 470                 475                 480 
Gln Tyr Ala Leu Ser Leu Ala Asn Leu Gln Met Val Leu Glu His Phe
                485                 490                 495     
Gln Gln Glu Glu Lys Ala Met Tyr Ser Ala Glu Leu Glu Lys Gln Lys
            500                 505                 510         
Gln Leu Ile Ala Glu Trp Lys Lys Asn Ala Glu Asn Leu Glu Gly Lys
        515                 520                 525             
Val Ile Ser Leu Gln Glu Cys Leu Asp Glu Ala Asn Ala Ala Leu Asp
    530                 535                 540                 
Ser Ala Ser Arg Leu Thr Glu Gln Leu Asp Val Lys Glu Glu Gln Ile
545                 550                 555                 560 
Glu Glu Leu Lys Arg Gln Asn Glu Leu Arg Gln Glu Met Leu Asp Asp
                565                 570                 575     
Val Gln Lys Lys Leu Met Ser Leu Ala Asn Ser Ser Glu Gly Lys Val
            580                 585                 590         
Asp Lys Val Leu Met Arg Asn Leu Phe Ile Gly His Phe His Thr Pro
        595                 600                 605             
Lys Asn Gln Arg His Glu Val Leu Arg Leu Met Gly Ser Ile Leu Gly
    610                 615                 620                 
Val Arg Arg Glu Glu Met Glu Gln Leu Phe His Asp Asp Gln Gly Ser
625                 630                 635                 640 
Val Thr Arg Trp Met Thr Gly Trp Leu Gly Gly Gly Ser Lys Ser Val
                645                 650                 655     
Pro Asn Thr Pro Leu Arg Pro Asn Gln Gln Ser Val Val Asn Ser Ser
            660                 665                 670         
Phe Ser Glu Leu Phe Val Lys Phe Leu Glu Thr Glu Ser His Pro Ser
        675                 680                 685             
Ile Pro Pro Pro Lys Leu Ser Val His Asp Met Lys Pro Leu Asp Ser
    690                 695                 700                 
Pro Gly Arg Arg Lys Arg Asp Thr Asn Ala Pro Glu Ser Phe Lys Asp
705                 710                 715                 720 
Thr Ala Glu Ser Arg Ser Gly Arg Arg Thr Asp Val Asn Pro Phe Leu
                725                 730                 735     
Ala Pro Arg Ser Ala Ala Val Pro Ser Leu Leu Thr Gln Leu Asp Leu
            740                 745                 750         
Asp Leu Val Gly Pro Gly Ile Phe Phe
        755                 760     


<210> 831
<211> 48
<212> PRT
<213> Homo sapiens

<400> 831
Pro Asp Gly Glu Cys Cys Pro Arg Cys Trp Pro Arg Cys Asp Cys Ser
 1               5                  10                  15      
Arg Gly Ala Trp Ala Asp Gly Lys Glu Thr Cys Cys Pro Leu Met Thr
            20                  25                  30          
Ile Cys Ala Glu Lys Ala Pro Asn Ala Gly Val Arg Gly Thr Thr Asn
        35                  40                  45              


<210> 832
<211> 232
<212> PRT
<213> Homo sapiens

<400> 832
Met Ala Pro Ser Val Pro Ala Ala Glu Pro Glu Tyr Pro Lys Gly Ile
 1               5                  10                  15      
Arg Ala Val Leu Leu Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala
            20                  25                  30          
Pro Arg Leu Ala Glu Asn Phe Cys Val Cys His Leu Ala Thr Gly Asp
        35                  40                  45              
Met Leu Arg Ala Met Val Ala Ser Gly Ser Glu Leu Gly Lys Lys Leu
    50                  55                  60                  
Lys Ala Thr Met Asp Ala Gly Lys Leu Val Ser Asp Glu Met Val Val
65                  70                  75                  80  
Glu Leu Ile Glu Lys Asn Leu Glu Thr Pro Leu Cys Lys Asn Gly Phe
                85                  90                  95      
Leu Leu Asp Gly Phe Pro Arg Thr Val Arg Gln Ala Glu Met Leu Asp
            100                 105                 110         
Asp Leu Met Glu Lys Arg Lys Glu Lys Leu Asp Ser Val Ile Glu Phe
        115                 120                 125             
Ser Ile Pro Asp Ser Leu Leu Ile Arg Arg Ile Thr Gly Arg Leu Ile
    130                 135                 140                 
His Pro Lys Ser Gly Arg Ser Tyr His Glu Glu Phe Asn Pro Pro Lys
145                 150                 155                 160 
Glu Pro Met Lys Asp Asp Ile Thr Gly Glu Pro Leu Ile Arg Arg Ser
                165                 170                 175     
Asp Asp Asn Glu Lys Ala Leu Lys Ile Arg Leu Gln Ala Tyr His Thr
            180                 185                 190         
Gln Thr Thr Pro Leu Ile Glu Tyr Tyr Arg Lys Arg Gly Ile His Ser
        195                 200                 205             
Ala Ile Asp Ala Ser Gln Thr Pro Asp Val Val Phe Ala Ser Ile Leu
    210                 215                 220                 
Ala Ala Phe Ser Lys Ala Thr Ser
225                 230         


<210> 833
<211> 806
<212> PRT
<213> Homo sapiens

<400> 833
Met Ser Ala Ser Pro Asp Asp Leu Ser Thr Gly Gly Arg Leu Gln Asn
 1               5                  10                  15      
Met Thr Val Asp Glu Cys Phe Gln Ser Arg Asn Thr Val Leu Gln Gly
            20                  25                  30          
Gln Pro Phe Gly Gly Val Pro Thr Val Leu Cys Leu Asn Ile Ala Leu
        35                  40                  45              
Trp Val Leu Val Leu Val Val Tyr Ser Phe Leu Arg Lys Ala Ala Trp
    50                  55                  60                  
Asp Tyr Gly Arg Leu Ala Leu Leu Ile His Asn Asp Ser Leu Thr Ser
65                  70                  75                  80  
Leu Ile Tyr Gly Glu Gln Ser Glu Lys Thr Ser Pro Ser Glu Thr Ser
                85                  90                  95      
Leu Glu Met Glu Arg Arg Asp Lys Gly Phe Cys Ser Trp Phe Phe Asn
            100                 105                 110         
Ser Ile Thr Met Lys Asp Glu Asp Leu Ile Asn Lys Cys Gly Asp Asp
        115                 120                 125             
Ala Arg Ile Tyr Ile Val Phe Gln Tyr His Leu Ile Ile Phe Val Leu
    130                 135                 140                 
Ile Ile Cys Ile Pro Ser Leu Gly Ile Ile Leu Pro Ile Asn Tyr Thr
145                 150                 155                 160 
Gly Ser Val Leu Asp Trp Ser Ser His Phe Ala Arg Thr Thr Ile Val
                165                 170                 175     
Asn Val Ser Thr Glu Ser Lys Leu Leu Trp Leu His Ser Leu Leu Ser
            180                 185                 190         
Phe Phe Tyr Phe Ile Thr Asn Phe Met Phe Met Ala His His Cys Leu
        195                 200                 205             
Gly Phe Ala Pro Arg Asn Ser Gln Lys Val Thr Arg Thr Leu Met Ile
    210                 215                 220                 
Thr Tyr Val Pro Lys Asp Ile Glu Asp Pro Glu Leu Ile Ile Lys His
225                 230                 235                 240 
Phe His Glu Ala Tyr Pro Gly Ser Val Val Thr Arg Val His Phe Cys
                245                 250                 255     
Tyr Asp Val Arg Asn Leu Ile Asp Leu Asp Asp Gln Arg Arg His Ala
            260                 265                 270         
Met Arg Gly Arg Leu Phe Tyr Thr Ala Lys Ala Lys Lys Thr Gly Lys
        275                 280                 285             
Val Met Ile Arg Ile His Pro Cys Ala Arg Leu Cys Phe Cys Lys Cys
    290                 295                 300                 
Trp Thr Cys Phe Lys Glu Val Asp Ala Glu Gln Tyr Tyr Ser Glu Leu
305                 310                 315                 320 
Glu Glu Gln Leu Thr Asp Glu Phe Asn Ala Glu Leu Asn Arg Val Pro
                325                 330                 335     
Leu Lys Arg Leu Asp Leu Ile Phe Val Thr Phe Gln Asp Ser Arg Met
            340                 345                 350         
Ala Lys Arg Val Arg Lys Asp Tyr Lys Tyr Val Gln Cys Gly Val Gln
        355                 360                 365             
Pro Gln Gln Ser Ser Val Thr Thr Ile Val Lys Ser Tyr Tyr Trp Arg
    370                 375                 380                 
Val Thr Met Ala Pro His Pro Lys Asp Ile Ile Trp Lys His Leu Ser
385                 390                 395                 400 
Val Arg Arg Phe Phe Trp Trp Ala Arg Phe Ile Ala Ile Asn Thr Phe
                405                 410                 415     
Leu Phe Phe Leu Phe Phe Phe Leu Thr Thr Pro Ala Ile Ile Met Asn
            420                 425                 430         
Thr Ile Asp Met Tyr Asn Val Thr Arg Pro Ile Glu Lys Leu Gln Asn
        435                 440                 445             
Pro Ile Val Thr Gln Phe Phe Pro Ser Val Met Leu Trp Gly Phe Thr
    450                 455                 460                 
Val Ile Leu Pro Leu Ile Val Tyr Phe Ser Ala Phe Leu Glu Ala His
465                 470                 475                 480 
Trp Thr Arg Ser Ser Gln Asn Leu Val Met Val His Lys Cys Tyr Ile
                485                 490                 495     
Phe Leu Val Phe Met Val Val Ile Leu Pro Ser Met Gly Leu Thr Ser
            500                 505                 510         
Leu Asp Val Phe Leu Arg Trp Leu Phe Asp Ile Tyr Tyr Leu Glu Gln
        515                 520                 525             
Ala Ser Ile Arg Phe Gln Cys Val Phe Leu Pro Asp Asn Gly Ala Phe
    530                 535                 540                 
Phe Val Asn Tyr Val Ile Thr Ala Ala Leu Leu Gly Thr Gly Met Glu
545                 550                 555                 560 
Leu Leu Arg Leu Gly Ser Leu Phe Cys Tyr Ser Thr Arg Leu Phe Phe
                565                 570                 575     
Ser Arg Ser Glu Pro Glu Arg Val Asn Ile Arg Lys Asn Gln Ala Ile
            580                 585                 590         
Asp Phe Gln Phe Gly Arg Glu Tyr Ala Trp Met Met Asn Val Phe Ser
        595                 600                 605             
Val Val Met Ala Tyr Ser Ile Thr Cys Pro Ile Ile Val Pro Phe Gly
    610                 615                 620                 
Leu Leu Tyr Leu Cys Met Lys His Leu Thr Asp Arg Tyr Asn Met Tyr
625                 630                 635                 640 
Tyr Ser Phe Ala Pro Thr Lys Leu Asn Glu Gln Ile His Met Ala Ala
                645                 650                 655     
Val Ser Gln Ala Ile Phe Ala Pro Leu Leu Gly Leu Phe Trp Met Leu
            660                 665                 670         
Phe Phe Ser Ile Leu Arg Leu Gly Ser Leu His Ala Ile Thr Ile Phe
        675                 680                 685             
Ser Leu Ser Thr Leu Leu Ile Ala Met Val Ile Ala Phe Val Gly Ile
    690                 695                 700                 
Phe Leu Gly Lys Leu Arg Met Val Ala Asp Tyr Glu Pro Glu Glu Glu
705                 710                 715                 720 
Glu Ile Gln Thr Val Phe Asp Met Glu Pro Ser Ser Thr Ser Ser Thr
                725                 730                 735     
Pro Thr Ser Leu Leu Tyr Val Ala Thr Val Leu Gln Glu Pro Glu Leu
            740                 745                 750         
Asn Leu Thr Pro Ala Ser Ser Pro Ala Arg His Thr Tyr Gly Thr Met
        755                 760                 765             
Asn Asn Gln Pro Glu Glu Gly Glu Glu Glu Ser Gly Leu Arg Gly Phe
    770                 775                 780                 
Ala Arg Glu Leu Asp Ser Ala Gln Phe Gln Glu Gly Leu Glu Leu Glu
785                 790                 795                 800 
Gly Gln Asn Gln Tyr His
                805     


<210> 834
<211> 342
<212> PRT
<213> Homo sapiens

<400> 834
Met Ala Glu Gly Gly Ser Gly Asp Val Asp Asp Ala Gly Asp Cys Ser
 1               5                  10                  15      
Gly Ala Arg Tyr Asn Asp Trp Ser Asp Asp Asp Asp Asp Ser Asn Glu
            20                  25                  30          
Ser Lys Ser Ile Val Trp Tyr Pro Pro Trp Ala Arg Ile Gly Thr Glu
        35                  40                  45              
Ala Gly Thr Arg Ala Arg Ala Arg Ala Arg Ala Arg Ala Thr Arg Ala
    50                  55                  60                  
Arg Arg Ala Val Gln Lys Arg Ala Ser Pro Asn Ser Asp Asp Thr Val
65                  70                  75                  80  
Leu Ser Pro Gln Glu Leu Gln Lys Val Leu Cys Leu Val Glu Met Ser
                85                  90                  95      
Glu Lys Pro Tyr Ile Leu Glu Ala Ala Leu Ile Ala Leu Gly Asn Asn
            100                 105                 110         
Ala Ala Tyr Ala Phe Asn Arg Asp Ile Ile Arg Asp Leu Gly Gly Leu
        115                 120                 125             
Pro Ile Val Ala Lys Ile Leu Asn Thr Arg Asp Pro Ile Val Lys Glu
    130                 135                 140                 
Lys Ala Leu Ile Val Leu Asn Asn Leu Ser Val Asn Ala Glu Asn Gln
145                 150                 155                 160 
Arg Arg Leu Lys Val Tyr Met Asn Gln Val Cys Asp Asp Thr Ile Thr
                165                 170                 175     
Ser Arg Leu Asn Ser Ser Val Gln Leu Ala Gly Leu Arg Leu Leu Thr
            180                 185                 190         
Asn Met Thr Val Thr Asn Glu Tyr Gln His Met Leu Ala Asn Ser Ile
        195                 200                 205             
Ser Asp Phe Phe Arg Leu Phe Ser Ala Gly Asn Glu Glu Thr Lys Leu
    210                 215                 220                 
Gln Val Leu Lys Leu Leu Leu Asn Leu Ala Glu Asn Pro Ala Met Thr
225                 230                 235                 240 
Arg Glu Leu Leu Arg Ala Gln Val Pro Ser Ser Leu Gly Ser Leu Phe
                245                 250                 255     
Asn Lys Lys Glu Asn Lys Glu Val Ile Leu Lys Leu Leu Val Ile Phe
            260                 265                 270         
Glu Asn Ile Asn Asp Asn Phe Lys Trp Glu Glu Asn Glu Pro Thr Gln
        275                 280                 285             
Asn Gln Phe Gly Glu Gly Ser Leu Phe Phe Phe Leu Lys Glu Phe Gln
    290                 295                 300                 
Val Cys Ala Asp Lys Val Leu Gly Ile Glu Ser His His Asp Phe Leu
305                 310                 315                 320 
Val Lys Val Lys Val Gly Lys Phe Met Ala Lys Leu Ala Glu His Met
                325                 330                 335     
Phe Pro Lys Ser Gln Glu
            340         


<210> 835
<211> 392
<212> PRT
<213> Homo sapiens

<400> 835
Met Asp Asp Pro Asp Cys Asp Ser Thr Trp Glu Glu Asp Glu Glu Asp
 1               5                  10                  15      
Ala Glu Asp Ala Glu Asp Glu Asp Cys Glu Asp Gly Glu Ala Ala Gly
            20                  25                  30          
Ala Arg Asp Ala Asp Ala Gly Asp Glu Asp Glu Glu Ser Glu Glu Pro
        35                  40                  45              
Arg Ala Ala Arg Pro Ser Ser Phe Gln Ser Arg Met Thr Gly Ser Arg
    50                  55                  60                  
Asn Trp Arg Ala Thr Arg Asp Met Cys Arg Tyr Arg His Asn Tyr Pro
65                  70                  75                  80  
Asp Leu Val Glu Arg Asp Cys Asn Gly Asp Thr Pro Asn Leu Ser Phe
                85                  90                  95      
Tyr Arg Asn Glu Ile Arg Phe Leu Pro Asn Gly Cys Phe Ile Glu Asp
            100                 105                 110         
Ile Leu Gln Asn Trp Thr Asp Asn Tyr Asp Leu Leu Glu Asp Asn His
        115                 120                 125             
Ser Tyr Ile Gln Trp Leu Phe Pro Leu Arg Glu Pro Gly Val Asn Trp
    130                 135                 140                 
His Ala Lys Pro Leu Thr Leu Arg Glu Val Glu Val Phe Lys Ser Ser
145                 150                 155                 160 
Gln Glu Ile Gln Glu Arg Leu Val Arg Ala Tyr Glu Leu Met Leu Gly
                165                 170                 175     
Phe Tyr Gly Ile Arg Leu Glu Asp Arg Gly Thr Gly Thr Val Gly Arg
            180                 185                 190         
Ala Gln Asn Tyr Gln Lys Arg Phe Gln Asn Leu Asn Trp Arg Ser His
        195                 200                 205             
Asn Asn Leu Arg Ile Thr Arg Ile Leu Lys Ser Pro Cys Glu Leu Ser
    210                 215                 220                 
Leu Glu His Phe Gln Ala Pro Leu Val Arg Phe Phe Leu Glu Glu Thr
225                 230                 235                 240 
Leu Val Arg Arg Glu Leu Pro Gly Val Arg Gln Ser Ala Leu Asp Tyr
                245                 250                 255     
Phe Met Phe Ala Val Arg Cys Arg His Gln Arg Arg Gln Leu Val His
            260                 265                 270         
Phe Ala Trp Glu His Phe Arg Pro Arg Cys Lys Phe Val Trp Gly Pro
        275                 280                 285             
Gln Asp Lys Leu Arg Arg Phe Lys Pro Ser Ser Leu Pro His Pro Leu
    290                 295                 300                 
Glu Gly Ser Arg Lys Val Glu Glu Glu Gly Pro Ala Gly Asp Glu Pro
305                 310                 315                 320 
Ala Glu Ser Pro Ser Glu Thr Pro Gly Pro Ser Pro Ala Gly Pro Thr
                325                 330                 335     
Arg Asp Glu Pro Ala Lys Ala Gly Glu Ala Glu Ala Cys Cys Leu Ala
            340                 345                 350         
Val Ser Ser His Pro Ala Leu Pro Cys Ala Pro Val Phe Val Asn Arg
        355                 360                 365             
Pro Phe Trp Ser Gly Gly Arg Arg Ala Gly Leu Ala Phe Leu Ser Leu
    370                 375                 380                 
Met Pro Ser Lys Ala Phe Ser Glu
385                 390         


<210> 836
<211> 226
<212> PRT
<213> Homo sapiens

<400> 836
Met Gly Pro Leu Pro Arg Thr Val Glu Leu Phe Tyr Asp Val Leu Ser
 1               5                  10                  15      
Pro Tyr Ser Trp Leu Gly Phe Glu Ile Leu Cys Arg Tyr Gln Asn Ile
            20                  25                  30          
Trp Asn Ile Asn Leu Gln Leu Arg Pro Ser Leu Ile Thr Gly Ile Met
        35                  40                  45              
Lys Asp Ser Gly Asn Lys Pro Pro Gly Leu Leu Pro Arg Lys Gly Leu
    50                  55                  60                  
Tyr Met Ala Asn Asp Leu Lys Leu Leu Arg His His Leu Gln Ile Pro
65                  70                  75                  80  
Ile His Phe Pro Lys Asp Phe Leu Ser Val Met Leu Glu Lys Gly Ser
                85                  90                  95      
Leu Ser Ala Met Arg Phe Leu Thr Ala Val Asn Leu Glu His Pro Glu
            100                 105                 110         
Met Leu Glu Lys Ala Ser Arg Glu Leu Trp Met Arg Val Trp Ser Arg
        115                 120                 125             
Asn Glu Asp Ile Thr Glu Pro Gln Ser Ile Leu Ala Ala Ala Glu Lys
    130                 135                 140                 
Ala Gly Met Ser Ala Glu Gln Ala Gln Gly Leu Leu Glu Lys Ile Ala
145                 150                 155                 160 
Thr Pro Lys Val Lys Asn Gln Leu Lys Glu Thr Thr Glu Ala Ala Cys
                165                 170                 175     
Arg Tyr Arg Ala Phe Gly Leu Pro Ile Thr Val Ala His Val Asp Gly
            180                 185                 190         
Gln Thr His Met Leu Phe Gly Ser Asp Arg Met Glu Leu Leu Ala His
        195                 200                 205             
Leu Leu Gly Glu Lys Trp Met Gly Pro Ile Pro Ser Ala Val Asn Ala
    210                 215                 220                 
Arg Leu
225     


<210> 837
<211> 813
<212> PRT
<213> Homo sapiens

<400> 837
Met Asp Ala Thr Ala Leu Glu Arg Asp Ala Val Gln Phe Ala Arg Leu
 1               5                  10                  15      
Ala Val Gln Arg Asp His Glu Gly Arg Tyr Ser Glu Ala Val Phe Tyr
            20                  25                  30          
Tyr Lys Glu Ala Ala Gln Ala Leu Ile Tyr Ala Glu Met Ala Gly Ser
        35                  40                  45              
Ser Leu Glu Asn Ile Gln Glu Lys Ile Thr Glu Tyr Leu Glu Arg Val
    50                  55                  60                  
Gln Ala Leu His Ser Ala Val Gln Ser Lys Ser Ala Asp Pro Leu Lys
65                  70                  75                  80  
Ser Lys His Gln Leu Asp Leu Glu Arg Ala His Phe Leu Val Thr Gln
                85                  90                  95      
Ala Phe Asp Glu Asp Glu Lys Glu Asn Val Glu Asp Ala Ile Glu Leu
            100                 105                 110         
Tyr Thr Glu Ala Val Asp Leu Cys Leu Lys Thr Ser Tyr Glu Thr Ala
        115                 120                 125             
Asp Lys Val Leu Gln Asn Lys Leu Lys Gln Leu Ala Arg Gln Ala Leu
    130                 135                 140                 
Asp Arg Ala Glu Ala Leu Ser Glu Pro Leu Thr Lys Pro Val Gly Lys
145                 150                 155                 160 
Ile Ser Ser Thr Ser Val Lys Pro Lys Pro Pro Pro Val Arg Ala His
                165                 170                 175     
Phe Pro Leu Gly Ala Asn Pro Phe Leu Glu Arg Pro Gln Ser Phe Ile
            180                 185                 190         
Ser Pro Gln Ser Cys Asp Ala Gln Gly Gln Arg Tyr Thr Ala Glu Glu
        195                 200                 205             
Ile Glu Val Leu Arg Thr Thr Ser Lys Ile Asn Gly Ile Glu Tyr Val
    210                 215                 220                 
Pro Phe Met Asn Val Asp Leu Arg Glu Arg Phe Ala Tyr Pro Met Pro
225                 230                 235                 240 
Phe Cys Asp Arg Trp Gly Lys Leu Pro Leu Ser Pro Lys Gln Lys Thr
                245                 250                 255     
Thr Phe Ser Lys Trp Val Arg Pro Glu Asp Leu Thr Asn Asn Pro Thr
            260                 265                 270         
Met Ile Tyr Thr Val Ser Ser Phe Ser Ile Lys Gln Thr Ile Val Ser
        275                 280                 285             
Asp Cys Ser Phe Val Ala Ser Leu Ala Ile Ser Ala Ala Tyr Glu Arg
    290                 295                 300                 
Arg Phe Asn Lys Lys Leu Ile Thr Gly Ile Ile Tyr Pro Gln Asn Lys
305                 310                 315                 320 
Asp Gly Glu Pro Glu Tyr Asn Pro Cys Gly Lys Tyr Met Val Lys Leu
                325                 330                 335     
His Leu Asn Gly Val Pro Arg Lys Val Ile Ile Asp Asp Gln Leu Pro
            340                 345                 350         
Val Asp His Lys Gly Glu Leu Leu Cys Ser Tyr Ser Asn Asn Lys Ser
        355                 360                 365             
Glu Leu Trp Val Ser Leu Ile Glu Lys Ala Tyr Met Lys Val Met Gly
    370                 375                 380                 
Gly Tyr Asp Phe Pro Gly Ser Asn Ser Asn Ile Asp Leu His Ala Leu
385                 390                 395                 400 
Thr Gly Trp Ile Pro Glu Arg Ile Ala Met His Ser Asp Ser Gln Thr
                405                 410                 415     
Phe Ser Lys Asp Asn Ser Phe Arg Met Leu Tyr Gln Arg Phe His Lys
            420                 425                 430         
Gly Asp Val Leu Ile Thr Ala Ser Thr Gly Met Met Thr Glu Ala Glu
        435                 440                 445             
Gly Glu Lys Trp Gly Leu Val Pro Thr His Ala Tyr Ala Val Leu Asp
    450                 455                 460                 
Ile Arg Glu Phe Lys Gly Leu Arg Phe Ile Gln Leu Lys Asn Pro Trp
465                 470                 475                 480 
Ser His Leu Arg Trp Lys Gly Arg Tyr Ser Glu Asn Asp Val Lys Asn
                485                 490                 495     
Trp Thr Pro Glu Leu Gln Lys Tyr Leu Asn Phe Asp Pro Arg Thr Ala
            500                 505                 510         
Gln Lys Ile Asp Asn Gly Ile Phe Trp Ile Ser Trp Asp Asp Leu Cys
        515                 520                 525             
Gln Tyr Tyr Asp Val Ile Tyr Leu Ser Trp Asn Pro Gly Leu Phe Lys
    530                 535                 540                 
Glu Ser Thr Cys Ile His Ser Thr Trp Asp Ala Lys Gln Gly Pro Val
545                 550                 555                 560 
Lys Asp Ala Tyr Ser Leu Ala Asn Asn Pro Gln Tyr Lys Leu Glu Val
                565                 570                 575     
Gln Cys Pro Gln Gly Gly Ala Ala Val Trp Val Leu Leu Ser Arg His
            580                 585                 590         
Ile Thr Asp Lys Asp Asp Phe Ala Asn Asn Arg Glu Phe Ile Thr Met
        595                 600                 605             
Val Val Tyr Lys Thr Asp Gly Lys Lys Val Tyr Tyr Pro Ala Asp Pro
    610                 615                 620                 
Pro Pro Tyr Ile Asp Gly Ile Arg Ile Asn Ser Pro His Tyr Leu Thr
625                 630                 635                 640 
Lys Ile Lys Leu Thr Thr Pro Gly Thr His Thr Phe Thr Leu Val Val
                645                 650                 655     
Ser Gln Tyr Glu Lys Gln Asn Thr Ile His Tyr Thr Val Arg Val Tyr
            660                 665                 670         
Ser Ala Cys Ser Phe Thr Phe Ser Lys Ile Pro Ser Pro Tyr Thr Leu
        675                 680                 685             
Ser Lys Arg Ile Asn Gly Lys Trp Ser Gly Gln Ser Ala Gly Gly Cys
    690                 695                 700                 
Gly Asn Phe Gln Glu Thr His Lys Asn Asn Pro Ile Tyr Gln Phe His
705                 710                 715                 720 
Ile Glu Lys Thr Gly Pro Leu Leu Ile Glu Leu Arg Gly Pro Arg Gln
                725                 730                 735     
Tyr Ser Val Gly Phe Glu Val Val Thr Val Ser Thr Leu Gly Asp Pro
            740                 745                 750         
Gly Pro His Gly Phe Leu Arg Lys Ser Ser Gly Asp Tyr Arg Cys Gly
        755                 760                 765             
Phe Cys Tyr Leu Glu Leu Glu Asn Ile Pro Ser Gly Ile Phe Asn Ile
    770                 775                 780                 
Ile Pro Ser Thr Phe Leu Pro Lys Gln Glu Gly Pro Phe Phe Leu Asp
785                 790                 795                 800 
Phe Asn Ser Ile Ile Pro Ile Lys Ile Thr Gln Leu Gln
                805                 810             


<210> 838
<211> 953
<212> PRT
<213> Homo sapiens

<400> 838
Met Thr Ser Ala Thr Ser Pro Ile Ile Leu Lys Trp Asp Pro Lys Ser
 1               5                  10                  15      
Leu Glu Ile Arg Thr Leu Thr Val Glu Arg Leu Leu Glu Pro Leu Val
            20                  25                  30          
Thr Gln Val Thr Thr Leu Val Asn Thr Ser Asn Lys Gly Pro Ser Gly
        35                  40                  45              
Lys Lys Lys Gly Arg Ser Lys Lys Ala His Val Leu Ala Ala Ser Val
    50                  55                  60                  
Glu Gln Ala Thr Gln Asn Phe Leu Glu Lys Gly Glu Gln Ile Ala Lys
65                  70                  75                  80  
Glu Ser Gln Asp Leu Lys Glu Glu Leu Val Ala Ala Val Glu Asp Val
                85                  90                  95      
Arg Lys Gln Gly Glu Thr Met Arg Ile Ala Ser Ser Glu Phe Ala Asp
            100                 105                 110         
Asp Pro Cys Ser Ser Val Lys Arg Gly Thr Met Val Arg Ala Ala Arg
        115                 120                 125             
Ala Leu Leu Ser Ala Val Thr Arg Leu Leu Ile Leu Ala Asp Met Ala
    130                 135                 140                 
Asp Val Met Arg Leu Leu Ser His Leu Lys Ile Val Glu Glu Ala Leu
145                 150                 155                 160 
Glu Ala Val Lys Asn Ala Thr Asn Glu Gln Asp Leu Ala Asn Arg Phe
                165                 170                 175     
Lys Glu Phe Gly Lys Lys Met Val Lys Leu Asn Tyr Val Ala Ala Arg
            180                 185                 190         
Arg Gln Gln Glu Leu Lys Asp Pro His Cys Arg Asp Glu Met Ala Ala
        195                 200                 205             
Ala Arg Gly Ala Leu Lys Lys Asn Ala Thr Met Leu Tyr Thr Ala Ser
    210                 215                 220                 
Gln Ala Phe Leu Arg His Pro Asp Val Ala Ala Thr Arg Ala Asn Arg
225                 230                 235                 240 
Asp Tyr Val Phe Lys Gln Val Gln Glu Ala Ile Ala Gly Ile Ser Asn
                245                 250                 255     
Ala Ala Gln Ala Thr Ser Pro Thr Asp Glu Ala Lys Gly His Thr Gly
            260                 265                 270         
Ile Gly Glu Leu Ala Ala Ala Leu Asn Glu Phe Asp Asn Lys Ile Ile
        275                 280                 285             
Leu Asp Pro Met Thr Phe Ser Glu Ala Arg Phe Arg Pro Ser Leu Glu
    290                 295                 300                 
Glu Arg Leu Glu Ser Ile Ile Ser Gly Ala Ala Leu Met Ala Asp Ser
305                 310                 315                 320 
Ser Cys Thr Arg Asp Asp Arg Arg Glu Arg Ile Val Ala Glu Cys Asn
                325                 330                 335     
Ala Val Arg Gln Ala Leu Gln Asp Leu Leu Ser Glu Tyr Met Asn Asn
            340                 345                 350         
Thr Gly Arg Lys Glu Lys Gly Asp Pro Leu Asn Ile Ala Ile Asp Lys
        355                 360                 365             
Met Thr Lys Lys Thr Arg Asp Leu Arg Arg Gln Leu Arg Lys Ala Val
    370                 375                 380                 
Met Asp His Ile Ser Asp Ser Phe Leu Glu Thr Asn Val Pro Leu Leu
385                 390                 395                 400 
Val Leu Ile Glu Ala Ala Lys Ser Gly Asn Glu Lys Glu Val Lys Glu
                405                 410                 415     
Tyr Ala Gln Val Phe Arg Glu His Ala Asn Lys Leu Val Glu Val Ala
            420                 425                 430         
Asn Leu Ala Cys Ser Ile Ser Asn Asn Glu Glu Gly Val Lys Leu Val
        435                 440                 445             
Arg Met Ala Ala Thr Gln Ile Asp Ser Leu Cys Pro Gln Val Ile Asn
    450                 455                 460                 
Ala Ala Leu Thr Leu Ala Ala Arg Pro Gln Ser Lys Val Ala Gln Asp
465                 470                 475                 480 
Asn Met Asp Val Phe Lys Asp Gln Trp Glu Lys Gln Val Arg Val Leu
                485                 490                 495     
Thr Glu Ala Val Asp Asp Ile Thr Ser Val Asp Asp Phe Leu Ser Val
            500                 505                 510         
Ser Glu Asn His Ile Leu Glu Asp Val Asn Lys Cys Val Ile Ala Leu
        515                 520                 525             
Gln Glu Gly Asp Val Asp Thr Leu Asp Arg Thr Ala Gly Ala Ile Arg
    530                 535                 540                 
Gly Arg Ala Ala Arg Val Ile His Ile Ile Asn Ala Glu Met Glu Asn
545                 550                 555                 560 
Tyr Glu Ala Gly Val Tyr Thr Glu Lys Val Leu Glu Ala Thr Lys Leu
                565                 570                 575     
Leu Ser Glu Thr Val Met Pro Arg Phe Ala Glu Gln Val Glu Val Ala
            580                 585                 590         
Ile Glu Ala Leu Ser Ala Asn Val Pro Gln Pro Phe Glu Glu Asn Glu
        595                 600                 605             
Phe Ile Asp Ala Ser Arg Leu Val Tyr Asp Gly Val Arg Asp Ile Arg
    610                 615                 620                 
Lys Ala Val Leu Met Ile Arg Thr Pro Glu Glu Leu Glu Asp Asp Ser
625                 630                 635                 640 
Asp Phe Glu Gln Glu Asp Tyr Asp Val Arg Arg Gly Thr Ser Val Gln
                645                 650                 655     
Thr Glu Asp Asp Gln Leu Ile Ala Gly Gln Ser Ala Arg Ala Ile Met
            660                 665                 670         
Ala Gln Leu Pro Gln Glu Glu Lys Ala Lys Ile Ala Glu Gln Val Glu
        675                 680                 685             
Ile Phe His Gln Glu Lys Ser Lys Leu Asp Ala Glu Val Ala Lys Trp
    690                 695                 700                 
Asp Asp Ser Gly Asn Asp Ile Ile Val Leu Ala Lys Gln Met Cys Met
705                 710                 715                 720 
Ile Met Met Glu Met Thr Asp Phe Thr Arg Gly Lys Gly Pro Leu Lys
                725                 730                 735     
Asn Thr Ser Asp Val Ile Asn Ala Ala Lys Lys Ile Ala Glu Ala Gly
            740                 745                 750         
Ser Arg Met Asp Lys Leu Ala Arg Ala Val Ala Asp Gln Cys Pro Asp
        755                 760                 765             
Ser Ala Cys Lys Gln Asp Leu Leu Ala Tyr Leu Gln Arg Ile Ala Leu
    770                 775                 780                 
Tyr Cys His Gln Leu Asn Ile Cys Ser Lys Val Lys Ala Glu Val Gln
785                 790                 795                 800 
Asn Leu Gly Gly Glu Leu Ile Val Ser Gly Thr Gly Val Gln Ser Thr
                805                 810                 815     
Phe Thr Thr Phe Tyr Glu Val Asp Cys Asp Val Ile Asp Gly Gly Arg
            820                 825                 830         
Ala Ser Gln Leu Ser Thr His Leu Pro Thr Cys Ala Glu Gly Ala Pro
        835                 840                 845             
Ile Gly Ser Gly Ser Ser Asp Ser Ser Met Leu Asp Ser Ala Thr Ser
    850                 855                 860                 
Leu Ile Gln Ala Ala Lys Asn Leu Met Asn Ala Val Val Leu Thr Val
865                 870                 875                 880 
Lys Ala Ser Tyr Val Ala Ser Thr Lys Tyr Gln Lys Val Tyr Gly Thr
                885                 890                 895     
Ala Ala Val Asn Ser Pro Val Val Ser Trp Lys Met Lys Ala Pro Glu
            900                 905                 910         
Lys Lys Pro Leu Val Lys Arg Glu Lys Pro Glu Glu Phe Gln Thr Arg
        915                 920                 925             
Val Arg Arg Gly Ser Gln Lys Lys His Ile Ser Pro Val Gln Ala Leu
    930                 935                 940                 
Ser Glu Phe Lys Ala Met Asp Ser Phe
945                 950             


<210> 839
<211> 655
<212> PRT
<213> Homo sapiens

<400> 839
Met Gly Thr Ser Pro Ser Ser Ser Thr Ala Leu Ala Ser Cys Ser Arg
 1               5                  10                  15      
Ile Ala Arg Arg Ala Thr Ala Thr Met Ile Ala Gly Ser Leu Leu Leu
            20                  25                  30          
Leu Gly Phe Leu Ser Thr Thr Thr Ala Gln Pro Glu Gln Lys Ala Ser
        35                  40                  45              
Asn Leu Ile Gly Thr Tyr Arg His Val Asp Arg Ala Thr Gly Gln Val
    50                  55                  60                  
Leu Thr Cys Asp Lys Cys Pro Ala Gly Thr Tyr Val Ser Glu His Cys
65                  70                  75                  80  
Thr Asn Thr Ser Leu Arg Val Cys Ser Ser Cys Pro Val Gly Thr Phe
                85                  90                  95      
Thr Arg His Glu Asn Gly Ile Glu Lys Cys His Asp Cys Ser Gln Pro
            100                 105                 110         
Cys Pro Trp Pro Met Ile Glu Lys Leu Pro Cys Ala Ala Leu Thr Asp
        115                 120                 125             
Arg Glu Cys Thr Cys Pro Pro Gly Met Phe Gln Ser Asn Ala Thr Cys
    130                 135                 140                 
Ala Pro His Thr Val Cys Pro Val Gly Trp Gly Val Arg Lys Lys Gly
145                 150                 155                 160 
Thr Glu Thr Glu Asp Val Arg Cys Lys Gln Cys Ala Arg Gly Thr Phe
                165                 170                 175     
Ser Asp Val Pro Ser Ser Val Met Lys Cys Lys Ala Tyr Thr Asp Cys
            180                 185                 190         
Leu Ser Gln Asn Leu Val Val Ile Lys Pro Gly Thr Lys Glu Thr Asp
        195                 200                 205             
Asn Val Cys Gly Thr Leu Pro Ser Phe Ser Ser Ser Thr Ser Pro Ser
    210                 215                 220                 
Pro Gly Thr Ala Ile Phe Pro Arg Pro Glu His Met Glu Thr His Glu
225                 230                 235                 240 
Val Pro Ser Ser Thr Tyr Val Pro Lys Gly Met Asn Ser Thr Glu Ser
                245                 250                 255     
Asn Ser Ser Ala Ser Val Arg Pro Lys Val Leu Ser Ser Ile Gln Glu
            260                 265                 270         
Gly Thr Val Pro Asp Asn Thr Ser Ser Ala Arg Gly Lys Glu Asp Val
        275                 280                 285             
Asn Lys Thr Leu Pro Asn Leu Gln Val Val Asn His Gln Gln Gly Pro
    290                 295                 300                 
His His Arg His Ile Leu Lys Leu Leu Pro Ser Met Glu Ala Thr Gly
305                 310                 315                 320 
Gly Glu Lys Ser Ser Thr Pro Ile Lys Gly Pro Lys Arg Gly His Pro
                325                 330                 335     
Arg Gln Asn Leu His Lys His Phe Asp Ile Asn Glu His Leu Pro Trp
            340                 345                 350         
Met Ile Val Leu Phe Leu Leu Leu Val Leu Val Val Ile Val Val Cys
        355                 360                 365             
Ser Ile Arg Lys Ser Ser Arg Thr Leu Lys Lys Gly Pro Arg Gln Asp
    370                 375                 380                 
Pro Ser Ala Ile Val Glu Lys Ala Gly Leu Lys Lys Ser Met Thr Pro
385                 390                 395                 400 
Thr Gln Asn Arg Glu Lys Trp Ile Tyr Tyr Cys Asn Gly His Gly Ile
                405                 410                 415     
Asp Ile Leu Lys Leu Val Ala Ala Gln Val Gly Ser Gln Trp Lys Asp
            420                 425                 430         
Ile Tyr Gln Phe Leu Cys Asn Ala Ser Glu Arg Glu Val Ala Ala Phe
        435                 440                 445             
Ser Asn Gly Tyr Thr Ala Asp His Glu Arg Ala Tyr Ala Ala Leu Gln
    450                 455                 460                 
His Trp Thr Ile Arg Gly Pro Glu Ala Ser Leu Ala Gln Leu Ile Ser
465                 470                 475                 480 
Ala Leu Arg Gln His Arg Arg Asn Asp Val Val Glu Lys Ile Arg Gly
                485                 490                 495     
Leu Met Glu Asp Thr Thr Gln Leu Glu Thr Asp Lys Leu Ala Leu Pro
            500                 505                 510         
Met Ser Pro Ser Pro Leu Ser Pro Ser Pro Ile Pro Ser Pro Asn Ala
        515                 520                 525             
Lys Leu Glu Asn Ser Ala Leu Leu Thr Val Glu Pro Ser Pro Gln Asp
    530                 535                 540                 
Lys Asn Lys Gly Phe Phe Val Asp Glu Ser Glu Pro Leu Leu Arg Cys
545                 550                 555                 560 
Asp Ser Thr Ser Ser Gly Ser Ser Ala Leu Ser Arg Asn Gly Ser Phe
                565                 570                 575     
Ile Thr Lys Glu Lys Lys Asp Thr Val Leu Arg Gln Val Arg Leu Asp
            580                 585                 590         
Pro Cys Asp Leu Gln Pro Ile Phe Asp Asp Met Leu His Phe Leu Asn
        595                 600                 605             
Pro Glu Glu Leu Arg Val Ile Glu Glu Ile Pro Gln Ala Glu Asp Lys
    610                 615                 620                 
Leu Asp Arg Leu Phe Glu Ile Ile Gly Val Lys Ser Gln Glu Ala Ser
625                 630                 635                 640 
Gln Thr Leu Leu Asp Ser Val Tyr Ser His Leu Pro Asp Leu Leu
                645                 650                 655 


<210> 840
<211> 148
<212> PRT
<213> Homo sapiens

<400> 840
Met Gly Ser Leu Ser Gly Leu Arg Leu Ala Ala Gly Ser Cys Phe Arg
 1               5                  10                  15      
Leu Cys Glu Arg Asp Val Ser Ser Ser Leu Arg Leu Thr Arg Ser Ser
            20                  25                  30          
Asp Leu Lys Arg Ile Asn Gly Phe Cys Thr Lys Pro Gln Glu Ser Pro
        35                  40                  45              
Gly Ala Pro Ser Arg Thr Tyr Asn Arg Val Pro Leu His Lys Pro Thr
    50                  55                  60                  
Asp Trp Gln Lys Lys Ile Leu Ile Trp Ser Gly Arg Phe Lys Lys Glu
65                  70                  75                  80  
Asp Glu Ile Pro Glu Thr Val Ser Leu Glu Met Leu Asp Ala Ala Lys
                85                  90                  95      
Asn Lys Met Arg Val Lys Ile Ser Tyr Leu Met Ile Ala Leu Thr Val
            100                 105                 110         
Val Gly Cys Ile Phe Met Val Ile Glu Gly Lys Lys Ala Ala Gln Arg
        115                 120                 125             
His Glu Thr Leu Thr Ser Leu Asn Leu Glu Lys Lys Ala Arg Leu Lys
    130                 135                 140                 
Glu Glu Gln Leu
145             


<210> 841
<211> 145
<212> PRT
<213> Homo sapiens

<400> 841
Met Val Gly Arg Asn Ser Ala Ile Ala Ala Gly Val Cys Gly Ala Leu
 1               5                  10                  15      
Phe Ile Gly Tyr Cys Ile Tyr Phe Asp Arg Lys Arg Arg Ser Asp Pro
            20                  25                  30          
Asn Phe Lys Asn Arg Leu Arg Glu Arg Arg Lys Lys Gln Lys Leu Ala
        35                  40                  45              
Lys Glu Arg Ala Gly Leu Ser Lys Leu Pro Asp Leu Lys Asp Ala Glu
    50                  55                  60                  
Ala Val Gln Lys Phe Phe Leu Glu Glu Ile Gln Leu Gly Glu Glu Leu
65                  70                  75                  80  
Leu Ala Gln Gly Glu Tyr Glu Lys Gly Val Asp His Leu Thr Asn Ala
                85                  90                  95      
Ile Ala Val Cys Gly Gln Pro Gln Gln Leu Leu Gln Val Leu Gln Gln
            100                 105                 110         
Thr Leu Pro Pro Pro Val Phe Gln Met Leu Leu Thr Lys Leu Pro Thr
        115                 120                 125             
Ile Ser Gln Arg Ile Val Ser Ala Gln Ser Leu Ala Glu Asp Asp Val
    130                 135                 140                 
Glu
145 


<210> 842
<211> 145
<212> PRT
<213> Homo sapiens

<400> 842
Met Val Gly Arg Asn Ser Ala Ile Ala Ala Gly Val Cys Gly Ala Leu
 1               5                  10                  15      
Phe Ile Gly Tyr Cys Ile Tyr Phe Asp Arg Lys Arg Arg Ser Asp Pro
            20                  25                  30          
Asn Phe Lys Asn Arg Leu Arg Glu Arg Arg Lys Lys Gln Lys Leu Ala
        35                  40                  45              
Lys Glu Arg Ala Gly Leu Ser Lys Leu Pro Asp Leu Lys Asp Ala Glu
    50                  55                  60                  
Ala Val Gln Lys Phe Phe Leu Glu Glu Ile Gln Leu Gly Glu Glu Leu
65                  70                  75                  80  
Leu Ala Gln Gly Glu Tyr Glu Lys Gly Val Asp His Leu Thr Asn Ala
                85                  90                  95      
Ile Ala Val Cys Gly Gln Pro Gln Gln Leu Leu Gln Val Leu Gln Gln
            100                 105                 110         
Thr Leu Pro Pro Pro Val Phe Gln Met Leu Leu Thr Lys Leu Pro Thr
        115                 120                 125             
Ile Ser Gln Arg Ile Val Ser Ala Gln Ser Leu Ala Glu Asp Asp Val
    130                 135                 140                 
Glu
145 


<210> 843
<211> 1038
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 910
<223> Xaa = Any Amino Acid

<400> 843
Met Trp Arg Cys Gly Gly Arg Gln Gly Leu Cys Val Leu Arg Arg Leu
 1               5                  10                  15      
Ser Gly Gly His Ala His His Arg Ala Trp Arg Trp Asn Ser Asn Arg
            20                  25                  30          
Ala Cys Glu Arg Ala Leu Gln Tyr Lys Leu Gly Asp Lys Ile His Gly
        35                  40                  45              
Phe Thr Val Asn Gln Val Thr Ser Val Pro Glu Leu Phe Leu Thr Ala
    50                  55                  60                  
Val Lys Leu Thr His Asp Asp Thr Gly Ala Arg Tyr Leu His Leu Ala
65                  70                  75                  80  
Arg Glu Asp Thr Asn Asn Leu Phe Ser Val Gln Phe Arg Thr Thr Pro
                85                  90                  95      
Met Asp Ser Thr Gly Val Pro His Ile Leu Glu His Thr Val Leu Cys
            100                 105                 110         
Gly Ser Gln Lys Tyr Pro Cys Arg Asn Pro Phe Phe Lys Met Leu Asn
        115                 120                 125             
Arg Ser Leu Ser Thr Phe Met Asn Ala Phe Thr Ala Ser Asp Tyr Thr
    130                 135                 140                 
Leu Tyr Pro Phe Ser Thr Gln Asn Pro Lys Asp Phe Gln Asn Leu Leu
145                 150                 155                 160 
Ser Val Tyr Leu Asp Ala Thr Phe Ser Pro Cys Leu Arg Glu Leu Asp
                165                 170                 175     
Phe Trp Gln Glu Gly Trp Arg Leu Glu His Glu Asn Pro Ser Asp Pro
            180                 185                 190         
Gln Thr Pro Leu Val Phe Lys Gly Val Val Phe Asn Glu Met Lys Gly
        195                 200                 205             
Ala Phe Thr Asp Asn Glu Arg Ile Phe Ser Gln His Leu Gln Asn Arg
    210                 215                 220                 
Leu Leu Pro Asp His Thr Tyr Ser Val Val Ser Gly Gly Asp Pro Leu
225                 230                 235                 240 
Cys Ile Pro Glu Leu Thr Trp Glu Gln Leu Lys Gln Phe His Ala Thr
                245                 250                 255     
His Tyr His Pro Ser Asn Ala Arg Phe Phe Thr Tyr Gly Asn Phe Pro
            260                 265                 270         
Leu Glu Gln His Leu Lys Gln Ile His Glu Glu Ala Leu Ser Lys Phe
        275                 280                 285             
Gln Lys Ile Glu Pro Ser Thr Val Val Pro Ala Gln Thr Pro Trp Asp
    290                 295                 300                 
Lys Pro Arg Glu Phe Gln Ile Thr Cys Gly Pro Asp Ser Phe Ala Thr
305                 310                 315                 320 
Asp Pro Ser Lys Gln Thr Thr Val Ser Val Ser Phe Leu Leu Pro Asp
                325                 330                 335     
Ile Thr Asp Thr Phe Glu Ala Phe Thr Leu Ser Leu Leu Ser Ser Leu
            340                 345                 350         
Leu Thr Ser Gly Pro Asn Ser Pro Phe Tyr Lys Ala Leu Ile Glu Ser
        355                 360                 365             
Gly Leu Gly Thr Glu Phe Ser Pro Asp Val Gly Tyr Asn Gly Tyr Thr
    370                 375                 380                 
Arg Glu Ala Tyr Phe Ser Val Gly Leu Gln Gly Ile Val Glu Lys Asp
385                 390                 395                 400 
Ile Glu Thr Val Arg Ser Leu Ile Asp Arg Thr Ile Asp Glu Val Val
                405                 410                 415     
Glu Thr Arg Ile Glu Asp Asp Arg Ile Glu Ala Leu Leu His Lys Ile
            420                 425                 430         
Glu Ile Gln Met Lys His Gln Ser Thr Ser Phe Gly Leu Met Leu Thr
        435                 440                 445             
Ser Tyr Ile Ala Ser Cys Trp Asn His Asp Gly Asp Pro Val Glu Leu
    450                 455                 460                 
Leu Lys Leu Gly Asn Gln Leu Ala Lys Phe Arg Gln Cys Leu Gln Glu
465                 470                 475                 480 
Asn Pro Lys Phe Leu Gln Glu Lys Val Lys Gln Tyr Phe Lys Asn Asn
                485                 490                 495     
Gln His Lys Leu Thr Leu Ser Met Arg Pro Asp Asp Lys Tyr His Glu
            500                 505                 510         
Lys Gln Ala Gln Val Glu Ala Thr Lys Leu Lys Gln Lys Val Glu Ala
        515                 520                 525             
Leu Ser Pro Gly Asp Arg Gln Gln Ile Tyr Glu Lys Gly Leu Glu Leu
    530                 535                 540                 
Arg Ser Gln Gln Ser Lys Pro Gln Asp Ala Ser Cys Leu Pro Ala Leu
545                 550                 555                 560 
Lys Val Ser Asp Ile Glu Pro Thr Ile Pro Val Thr Glu Leu Asp Val
                565                 570                 575     
Val Leu Thr Ala Gly Asp Ile Pro Val Gln Tyr Cys Ala Gln Pro Thr
            580                 585                 590         
Asn Gly Met Val Tyr Phe Arg Ala Phe Ser Ser Leu Asn Thr Leu Pro
        595                 600                 605             
Glu Glu Leu Arg Pro Tyr Val Pro Leu Phe Cys Ser Ile Leu Thr Lys
    610                 615                 620                 
Leu Gly Cys Gly Leu Leu Asp Tyr Arg Glu Gln Ala Gln Gln Ile Glu
625                 630                 635                 640 
Leu Lys Thr Gly Gly Met Ser Ala Ser Pro His Val Leu Pro Asp Asp
                645                 650                 655     
Ser His Met Asp Thr Tyr Glu Gln Val Gly Val Leu Phe Ser Ser Leu
            660                 665                 670         
Cys Leu Asp Arg Asn Leu Pro Asp Met Met Gln Leu Trp Ser Glu Ile
        675                 680                 685             
Phe Asn Asn Pro Cys Phe Glu Glu Glu Glu His Phe Lys Val Leu Val
    690                 695                 700                 
Lys Met Thr Ala Gln Glu Leu Ala Asn Gly Ile Pro Asp Ser Gly His
705                 710                 715                 720 
Leu Tyr Ala Ser Ile Arg Ala Gly Arg Thr Leu Thr Pro Ala Gly Asp
                725                 730                 735     
Leu Gln Glu Thr Phe Ser Gly Met Asp Gln Val Arg Leu Met Lys Arg
            740                 745                 750         
Ile Ala Glu Met Thr Asp Ile Lys Pro Ile Leu Arg Lys Leu Pro Arg
        755                 760                 765             
Ile Lys Lys His Leu Leu Asn Gly Asp Asn Met Arg Cys Ser Val Asn
    770                 775                 780                 
Ala Thr Pro Gln Gln Met Pro Gln Thr Glu Lys Ala Val Glu Asp Phe
785                 790                 795                 800 
Leu Arg Ser Ile Gly Arg Ser Lys Lys Glu Arg Arg Pro Val Arg Pro
                805                 810                 815     
His Thr Val Glu Lys Pro Val Pro Ser Ser Ser Gly Gly Asp Ala His
            820                 825                 830         
Val Pro His Gly Ser Gln Val Ile Arg Lys Leu Val Met Glu Pro Thr
        835                 840                 845             
Phe Lys Pro Trp Gln Met Lys Thr His Phe Leu Met Pro Phe Pro Val
    850                 855                 860                 
Asn Tyr Val Gly Glu Cys Ile Arg Thr Val Pro Tyr Thr Asp Pro Asp
865                 870                 875                 880 
His Ala Ser Leu Lys Ile Leu Ala Arg Leu Met Thr Ala Lys Phe Leu
                885                 890                 895     
His Thr Glu Ile Arg Glu Lys Gly Gly Ala Tyr Gly Gly Xaa Ala Lys
            900                 905                 910         
Leu Ser His Asn Gly Ile Phe Thr Leu Tyr Ser Tyr Arg Asp Pro Asn
        915                 920                 925             
Thr Ile Glu Thr Leu Gln Ser Phe Gly Lys Ala Val Asp Trp Ala Lys
    930                 935                 940                 
Ser Gly Lys Phe Thr Gln Gln Asp Ile Asp Glu Ala Lys Leu Ser Val
945                 950                 955                 960 
Phe Ser Thr Val Asp Ala Pro Val Ala Pro Ser Asp Lys Gly Met Asp
                965                 970                 975     
His Phe Leu Tyr Gly Leu Ser Asp Glu Met Lys Gln Ala His Arg Glu
            980                 985                 990         
Gln Leu Phe Ala Val Ser His Asp Lys Leu Leu Ala Val Ser Asp Arg
        995                 1000                1005            
Tyr Leu Gly Thr Gly Lys Ser Thr His Gly Leu Ala Ile Leu Gly Pro
    1010                1015                1020                
Glu Asn Pro Lys Ile Ala Lys Asp Pro Ser Trp Ile Ile Arg
1025                1030                1035            


<210> 844
<211> 303
<212> PRT
<213> Homo sapiens

<400> 844
Met Ala Asp Ala Ala Ser Gln Val Leu Leu Gly Ser Gly Leu Thr Ile
 1               5                  10                  15      
Leu Ser Gln Pro Leu Met Tyr Val Lys Val Leu Ile Gln Val Gly Tyr
            20                  25                  30          
Glu Pro Leu Pro Pro Thr Ile Gly Arg Asn Ile Phe Gly Arg Gln Val
        35                  40                  45              
Cys Gln Leu Pro Gly Leu Phe Ser Tyr Ala Gln His Ile Ala Ser Ile
    50                  55                  60                  
Asp Gly Arg Arg Gly Leu Phe Thr Gly Leu Thr Pro Arg Leu Cys Ser
65                  70                  75                  80  
Gly Val Leu Gly Thr Val Val His Gly Lys Val Leu Gln His Tyr Gln
                85                  90                  95      
Glu Ser Asp Lys Gly Glu Glu Leu Gly Pro Gly Asn Val Gln Lys Glu
            100                 105                 110         
Val Ser Ser Ser Phe Asp His Val Ile Lys Glu Thr Thr Arg Glu Met
        115                 120                 125             
Ile Ala Arg Ser Ala Ala Thr Leu Ile Thr His Pro Phe His Val Ile
    130                 135                 140                 
Thr Leu Arg Ser Met Val Gln Phe Ile Gly Arg Glu Ser Lys Tyr Cys
145                 150                 155                 160 
Gly Leu Cys Asp Ser Ile Ile Thr Ile Tyr Arg Glu Glu Gly Ile Leu
                165                 170                 175     
Gly Phe Phe Ala Gly Leu Val Pro Arg Leu Leu Gly Asp Ile Leu Ser
            180                 185                 190         
Leu Trp Leu Cys Asn Ser Leu Ala Tyr Leu Val Asn Thr Tyr Ala Leu
        195                 200                 205             
Asp Ser Gly Val Ser Thr Met Asn Glu Met Lys Ser Tyr Ser Gln Ala
    210                 215                 220                 
Val Thr Gly Phe Phe Ala Ser Met Leu Thr Tyr Pro Phe Val Leu Val
225                 230                 235                 240 
Ser Asn Leu Met Ala Val Asn Asn Cys Gly Leu Ala Gly Gly Cys Pro
                245                 250                 255     
Pro Tyr Ser Pro Ile Tyr Thr Ser Trp Ile Asp Cys Trp Cys Met Leu
            260                 265                 270         
Gln Lys Glu Gly Asn Met Ser Arg Gly Asn Ser Leu Phe Phe Arg Lys
        275                 280                 285             
Val Pro Phe Gly Lys Thr Tyr Cys Cys Asp Leu Lys Met Leu Ile
    290                 295                 300             


<210> 845
<211> 303
<212> PRT
<213> Homo sapiens

<400> 845
Met Ala Asp Ala Ala Ser Gln Val Leu Leu Gly Ser Gly Leu Thr Ile
 1               5                  10                  15      
Leu Ser Gln Pro Leu Met Tyr Val Lys Val Leu Ile Gln Val Gly Tyr
            20                  25                  30          
Glu Pro Leu Pro Pro Thr Ile Gly Arg Asn Ile Phe Gly Arg Gln Val
        35                  40                  45              
Cys Gln Leu Pro Gly Leu Phe Ser Tyr Ala Gln His Ile Ala Ser Ile
    50                  55                  60                  
Asp Gly Arg Arg Gly Leu Phe Thr Gly Leu Thr Pro Arg Leu Cys Ser
65                  70                  75                  80  
Gly Val Leu Gly Thr Val Val His Gly Lys Val Leu Gln His Tyr Gln
                85                  90                  95      
Glu Ser Asp Lys Gly Glu Glu Leu Gly Pro Gly Asn Val Gln Lys Glu
            100                 105                 110         
Val Ser Ser Ser Phe Asp His Val Ile Lys Glu Thr Thr Arg Glu Met
        115                 120                 125             
Ile Ala Arg Ser Ala Ala Thr Leu Ile Thr His Pro Phe His Val Ile
    130                 135                 140                 
Thr Leu Arg Ser Met Val Gln Phe Ile Gly Arg Glu Ser Lys Tyr Cys
145                 150                 155                 160 
Gly Leu Cys Asp Ser Ile Ile Thr Ile Tyr Arg Glu Glu Gly Ile Leu
                165                 170                 175     
Gly Phe Phe Ala Gly Leu Val Pro Arg Leu Leu Gly Asp Ile Leu Ser
            180                 185                 190         
Leu Trp Leu Cys Asn Ser Leu Ala Tyr Leu Val Asn Thr Tyr Ala Leu
        195                 200                 205             
Asp Ser Gly Val Ser Thr Met Asn Glu Met Lys Ser Tyr Ser Gln Ala
    210                 215                 220                 
Val Thr Gly Phe Phe Ala Ser Met Leu Thr Tyr Pro Phe Val Leu Val
225                 230                 235                 240 
Ser Asn Leu Met Ala Val Asn Asn Cys Gly Leu Ala Gly Gly Cys Pro
                245                 250                 255     
Pro Tyr Ser Pro Ile Tyr Thr Ser Trp Ile Asp Cys Trp Cys Met Leu
            260                 265                 270         
Gln Lys Glu Gly Asn Met Ser Arg Gly Asn Ser Leu Phe Phe Arg Lys
        275                 280                 285             
Val Pro Phe Gly Lys Thr Tyr Cys Cys Asp Leu Lys Met Leu Ile
    290                 295                 300             


<210> 846
<211> 172
<212> PRT
<213> Homo sapiens

<400> 846
Met Pro Gly Ile Val Glu Leu Pro Thr Leu Glu Glu Leu Lys Val Asp
 1               5                  10                  15      
Glu Val Lys Ile Ser Ser Ala Val Leu Lys Ala Ala Ala His His Tyr
            20                  25                  30          
Gly Ala Gln Cys Asp Lys Pro Asn Lys Glu Phe Met Leu Cys Arg Trp
        35                  40                  45              
Glu Glu Lys Asp Pro Arg Arg Cys Leu Glu Glu Gly Lys Leu Val Asn
    50                  55                  60                  
Lys Cys Ala Leu Asp Phe Phe Arg Gln Ile Lys Arg His Cys Ala Glu
65                  70                  75                  80  
Pro Phe Thr Glu Tyr Trp Thr Cys Ile Asp Tyr Thr Gly Gln Gln Leu
                85                  90                  95      
Phe Arg His Cys Arg Lys Gln Gln Ala Lys Phe Asp Glu Cys Val Leu
            100                 105                 110         
Asp Lys Leu Gly Trp Val Arg Pro Asp Leu Gly Glu Leu Ser Lys Val
        115                 120                 125             
Thr Lys Val Lys Thr Asp Arg Pro Leu Pro Glu Asn Pro Tyr His Ser
    130                 135                 140                 
Arg Pro Arg Pro Asp Pro Ser Pro Glu Ile Glu Gly Asp Leu Gln Pro
145                 150                 155                 160 
Ala Thr His Gly Ser Arg Phe Tyr Phe Trp Thr Lys
                165                 170         


<210> 847
<211> 428
<212> PRT
<213> Homo sapiens

<400> 847
Met Asp Ser Leu Trp Gly Pro Gly Ala Gly Ser His Pro Phe Gly Val
 1               5                  10                  15      
His Asn Thr Arg Leu Ser Pro Asp Leu Cys Pro Gly Lys Ile Val Leu
            20                  25                  30          
Arg Ala Leu Lys Glu Ser Gly Ala Gly Met Pro Glu Gln Asp Lys Asp
        35                  40                  45              
Pro Arg Val Gln Glu Asn Pro Gly Asp Gln Arg Arg Val Pro Glu Val
    50                  55                  60                  
Thr Gly Asp Ala Pro Ser Ala Phe Arg Pro Leu Arg Asp Asn Gly Gly
65                  70                  75                  80  
Leu Ser Pro Phe Val Pro Gly Pro Gly Pro Leu Gln Thr Asp Leu His
                85                  90                  95      
Ala Gln Arg Ser Glu Ile Arg Tyr Asn Gln Thr Ser Gln Thr Ser Trp
            100                 105                 110         
Thr Ser Ser Cys Thr Asn Arg Asn Ala Ile Ser Ser Ser Tyr Ser Ser
        115                 120                 125             
Thr Gly Gly Leu Pro Gly Leu Lys Arg Arg Arg Gly Pro Ala Ser Ser
    130                 135                 140                 
His Cys Gln Leu Thr Leu Ser Ser Ser Lys Thr Val Ser Glu Asp Arg
145                 150                 155                 160 
Pro Gln Ala Val Ser Ser Gly His Thr Gln Cys Glu Lys Ala Ala Asp
                165                 170                 175     
Ile Ala Pro Gly Gln Thr Leu Thr Leu Arg Asn Asp Ser Ser Thr Ser
            180                 185                 190         
Glu Ala Ser Arg Pro Ser Thr His Lys Phe Pro Leu Leu Pro Cys Arg
        195                 200                 205             
Arg Gly Glu Pro Leu Met Leu Pro Pro Pro Leu Glu Leu Gly Tyr Arg
    210                 215                 220                 
Val Thr Val Glu Asp Leu Asp Arg Glu Lys Glu Ala Ala Phe Gln Arg
225                 230                 235                 240 
Ile Asn Ser Ala Leu Gln Val Glu Asp Lys Ala Ile Ser Asp Cys Arg
                245                 250                 255     
Pro Ser Arg Pro Ser His Thr Leu Ser Ser Leu Ala Thr Gly Ala Ser
            260                 265                 270         
Gly Leu Pro Ala Val Ser Lys Ala Pro Ser Met Asp Ala Gln Gln Glu
        275                 280                 285             
Thr His Lys Ser Gln Asp Cys Leu Gly Leu Leu Ala Pro Leu Ala Ser
    290                 295                 300                 
Ala Ala Glu Val Pro Ser Thr Ala Pro Met Ser Gly Lys Lys His Arg
305                 310                 315                 320 
Pro Pro Gly Pro Leu Phe Ser Ser Ser Asp Pro Leu Pro Ala Thr Ser
                325                 330                 335     
Ser His Ser Gln Asp Ser Ala Gln Val Thr Ser Leu Ile Pro Ala Pro
            340                 345                 350         
Phe Pro Ala Ala Ser Met Asp Ala Gly Met Arg Arg Thr Arg Arg Gly
        355                 360                 365             
Thr Ser Ala Pro Ala Ala Ala Ala Ala Ala Pro Pro Pro Ser Ala Leu
    370                 375                 380                 
Asn Pro Thr Leu Gly Ser Leu Leu Glu Trp Met Glu Ala Leu His Ile
385                 390                 395                 400 
Ser Gly Pro Gln Pro Gln Leu Gln Gln Val Pro Arg Gly Gln Asn Gln
                405                 410                 415     
Arg Ser Gln Thr Ser Arg Thr Ser Ser Cys Pro Lys
            420                 425             


<210> 848
<211> 93
<212> PRT
<213> Homo sapiens

<400> 848
Met Gly Arg Glu Phe Gly Asn Leu Thr Arg Met Arg His Val Ile Ser
 1               5                  10                  15      
Tyr Ser Leu Ser Pro Phe Glu Gln Arg Ala Tyr Pro His Val Phe Thr
            20                  25                  30          
Lys Gly Ile Pro Asn Val Leu Arg Arg Ile Arg Glu Ser Phe Phe Arg
        35                  40                  45              
Val Val Pro Gln Phe Val Val Phe Tyr Leu Ile Tyr Thr Trp Gly Thr
    50                  55                  60                  
Glu Glu Phe Glu Arg Ser Lys Arg Arg Ile Gln Leu Pro Met Lys Met
65                  70                  75                  80  
Thr Asn Glu Gln Arg Ile Arg Met Thr Val Pro Cys Leu
                85                  90              


<210> 849
<211> 3829
<212> PRT
<213> Homo sapiens

<400> 849
Met Asn Thr Phe Trp Pro Gly Arg Glu Leu Ile Val Gln Trp Tyr Pro
 1               5                  10                  15      
Phe Asp Glu Asn Arg Asn His Pro Ser Val Ser Trp Leu Lys Met Val
            20                  25                  30          
Trp Lys Asn Leu Tyr Ile His Phe Ser Glu Asp Leu Thr Leu Phe Asp
        35                  40                  45              
Glu Met Pro Leu Ile Pro Arg Thr Ile Leu Glu Glu Gly Gln Thr Cys
    50                  55                  60                  
Val Glu Leu Ile Arg Leu Arg Ile Pro Ser Leu Val Ile Leu Asp Asp
65                  70                  75                  80  
Glu Ser Glu Ala Gln Leu Pro Glu Phe Leu Ala Asp Ile Val Gln Lys
                85                  90                  95      
Leu Gly Gly Phe Val Leu Lys Lys Leu Asp Ala Ser Ile Gln His Pro
            100                 105                 110         
Leu Ile Lys Lys Tyr Ile His Ser Pro Leu Pro Ser Ala Val Leu Gln
        115                 120                 125             
Ile Met Glu Lys Met Pro Leu Gln Lys Leu Cys Asn Gln Ile Thr Ser
    130                 135                 140                 
Leu Leu Pro Thr His Lys Asp Ala Leu Arg Lys Phe Leu Ala Ser Leu
145                 150                 155                 160 
Thr Asp Ser Ser Glu Lys Glu Lys Arg Ile Ile Gln Glu Leu Ala Ile
                165                 170                 175     
Phe Lys Arg Ile Asn His Ser Ser Asp Gln Gly Ile Ser Ser Tyr Thr
            180                 185                 190         
Lys Leu Lys Gly Cys Lys Val Leu His His Thr Ala Lys Leu Pro Ala
        195                 200                 205             
Asp Leu Arg Leu Ser Ile Ser Val Ile Asp Ser Ser Asp Glu Ala Thr
    210                 215                 220                 
Ile Arg Leu Ala Asn Met Leu Lys Ile Glu Gln Leu Lys Thr Thr Ser
225                 230                 235                 240 
Cys Leu Lys Leu Val Leu Lys Asp Ile Glu Asn Ala Phe Tyr Ser His
                245                 250                 255     
Glu Glu Val Thr Gln Leu Met Leu Trp Val Leu Glu Asn Leu Ser Ser
            260                 265                 270         
Leu Lys Asn Glu Asn Pro Asn Val Leu Glu Trp Leu Thr Pro Leu Lys
        275                 280                 285             
Phe Ile Gln Ile Ser Gln Glu Gln Met Val Ser Ala Gly Glu Leu Phe
    290                 295                 300                 
Asp Pro Asp Ile Glu Val Leu Lys Asp Leu Phe Cys Asn Glu Glu Gly
305                 310                 315                 320 
Thr Tyr Phe Pro Pro Ser Val Phe Thr Ser Pro Asp Ile Leu His Ser
                325                 330                 335     
Leu Arg Gln Ile Gly Leu Lys Asn Glu Ala Ser Leu Lys Glu Lys Asp
            340                 345                 350         
Val Val Gln Val Ala Lys Lys Ile Glu Ala Leu Gln Val Gly Ala Cys
        355                 360                 365             
Pro Asp Gln Asp Val Leu Leu Lys Lys Ala Lys Thr Leu Leu Leu Val
    370                 375                 380                 
Leu Asn Lys Asn His Thr Leu Leu Gln Ser Ser Glu Gly Lys Met Thr
385                 390                 395                 400 
Leu Lys Lys Ile Lys Trp Val Pro Ala Cys Lys Glu Arg Pro Pro Asn
                405                 410                 415     
Tyr Pro Gly Ser Leu Val Trp Lys Gly Asp Leu Cys Asn Leu Cys Ala
            420                 425                 430         
Pro Pro Asp Met Cys Asp Val Gly His Ala Ile Leu Ile Gly Ser Ser
        435                 440                 445             
Leu Pro Leu Val Glu Ser Ile His Val Asn Leu Glu Lys Ala Leu Gly
    450                 455                 460                 
Ile Phe Thr Lys Pro Ser Leu Ser Ala Val Leu Lys His Phe Lys Ile
465                 470                 475                 480 
Val Val Asp Trp Tyr Ser Ser Lys Thr Phe Ser Asp Glu Asp Tyr Tyr
                485                 490                 495     
Gln Phe Gln His Ile Leu Leu Glu Ile Tyr Gly Phe Met His Asp His
            500                 505                 510         
Leu Asn Glu Gly Lys Asp Ser Phe Arg Ala Leu Lys Phe Pro Trp Val
        515                 520                 525             
Trp Thr Gly Lys Lys Phe Cys Pro Leu Ala Gln Ala Val Ile Lys Pro
    530                 535                 540                 
Ile His Asp Leu Asp Leu Gln Pro Tyr Leu His Asn Val Pro Lys Thr
545                 550                 555                 560 
Met Ala Lys Phe His Gln Leu Phe Lys Val Cys Gly Ser Ile Glu Glu
                565                 570                 575     
Leu Thr Ser Asp His Ile Ser Met Val Ile Gln Lys Ile Tyr Leu Lys
            580                 585                 590         
Ser Asp Gln Asp Leu Ser Glu Gln Glu Ser Lys Gln Asn Leu His Leu
        595                 600                 605             
Met Leu Asn Ile Ile Arg Trp Leu Tyr Ser Asn Gln Ile Pro Ala Ser
    610                 615                 620                 
Pro Asn Thr Pro Val Pro Ile His His Ser Lys Asn Pro Ser Lys Leu
625                 630                 635                 640 
Ile Met Lys Pro Ile His Glu Cys Cys Tyr Cys Asp Ile Lys Val Asp
                645                 650                 655     
Asp Leu Asn Asp Leu Leu Glu Asp Ser Val Glu Pro Ile Ile Leu Val
            660                 665                 670         
His Glu Asp Ile Pro Met Lys Thr Ala Glu Trp Leu Lys Val Pro Cys
        675                 680                 685             
Leu Ser Thr Arg Leu Ile Asn Pro Glu Asn Met Gly Phe Glu Gln Ser
    690                 695                 700                 
Gly Gln Arg Glu Pro Leu Thr Val Arg Ile Lys Asn Ile Leu Glu Glu
705                 710                 715                 720 
Tyr Pro Ser Val Ser Asp Ile Phe Lys Glu Leu Leu Gln Asn Ala Asp
                725                 730                 735     
Asp Ala Asn Ala Thr Glu Cys Ser Phe Leu Ile Asp Met Arg Arg Asn
            740                 745                 750         
Met Asp Ile Arg Glu Asn Leu Leu Asp Pro Gly Met Ala Ala Cys His
        755                 760                 765             
Gly Pro Ala Leu Trp Ser Phe Asn Asn Ser Gln Phe Ser Asp Ser Asp
    770                 775                 780                 
Phe Val Asn Ile Thr Arg Leu Gly Glu Ser Leu Lys Arg Gly Glu Val
785                 790                 795                 800 
Asp Lys Val Gly Lys Phe Gly Leu Gly Phe Asn Ser Val Tyr His Ile
                805                 810                 815     
Thr Asp Ile Pro Ile Ile Met Ser Arg Glu Phe Met Ile Met Phe Asp
            820                 825                 830         
Pro Asn Ile Asn His Ile Ser Lys His Ile Lys Asp Lys Ser Asn Pro
        835                 840                 845             
Gly Ile Lys Ile Asn Trp Ser Lys Gln Gln Lys Arg Leu Arg Lys Phe
    850                 855                 860                 
Pro Asn Gln Phe Lys Pro Phe Ile Asp Val Phe Gly Cys Gln Leu Pro
865                 870                 875                 880 
Leu Thr Val Glu Ala Pro Tyr Ser Tyr Asn Gly Thr Leu Phe Arg Leu
                885                 890                 895     
Ser Phe Arg Thr Gln Gln Glu Ala Lys Val Ser Glu Val Ser Ser Thr
            900                 905                 910         
Cys Tyr Asn Thr Ala Asp Ile Tyr Ser Leu Val Asp Glu Phe Ser Leu
        915                 920                 925             
Cys Gly His Arg Leu Ile Ile Phe Thr Gln Ser Val Lys Ser Met Tyr
    930                 935                 940                 
Leu Lys Tyr Leu Lys Ile Glu Glu Thr Asn Pro Ser Leu Ala Gln Asp
945                 950                 955                 960 
Thr Val Ile Ile Lys Lys Lys Ser Cys Ser Ser Lys Ala Leu Asn Thr
                965                 970                 975     
Pro Val Leu Ser Val Leu Lys Glu Ala Ala Lys Leu Met Lys Thr Cys
            980                 985                 990         
Ser Ser Ser Asn Lys Lys Leu Pro Ser Asp Glu Pro Lys Ser Ser Cys
        995                 1000                1005            
Ile Leu Gln Ile Thr Val Glu Glu Phe His His Val Phe Arg Arg Ile
    1010                1015                1020                
Ala Asp Leu Gln Ser Pro Leu Phe Arg Gly Pro Asp Asp Asp Pro Ala
1025                1030                1035                1040
Ala Leu Phe Glu Met Ala Lys Ser Gly Gln Ser Lys Lys Pro Ser Asp
                1045                1050                1055    
Glu Leu Ser Gln Lys Thr Val Glu Cys Thr Thr Trp Leu Leu Cys Thr
            1060                1065                1070        
Cys Met Asp Thr Gly Glu Ala Leu Lys Phe Ser Leu Ser Glu Ser Gly
        1075                1080                1085            
Arg Arg Leu Gly Leu Val Pro Cys Gly Ala Val Gly Val Gln Leu Ser
    1090                1095                1100                
Glu Ile Gln Asp Gln Lys Trp Thr Val Lys Pro His Ile Gly Glu Val
1105                1110                1115                1120
Phe Cys Tyr Leu Pro Leu Arg Ile Lys Thr Gly Leu Pro Val His Ile
                1125                1130                1135    
Asn Gly Cys Phe Ala Val Thr Ser Asn Arg Lys Glu Ile Trp Lys Thr
            1140                1145                1150        
Asp Thr Lys Gly Arg Trp Asn Thr Thr Phe Met Arg His Val Ile Val
        1155                1160                1165            
Lys Ala Tyr Leu Gln Val Leu Ser Val Leu Arg Asp Leu Ala Thr Ser
    1170                1175                1180                
Gly Glu Leu Met Asp Tyr Thr Tyr Tyr Ala Val Trp Pro Asp Pro Asp
1185                1190                1195                1200
Leu Val His Asp Asp Phe Ser Val Ile Cys Gln Gly Phe Tyr Glu Asp
                1205                1210                1215    
Ile Ala His Gly Lys Gly Lys Glu Leu Thr Lys Val Phe Ser Asp Gly
            1220                1225                1230        
Ser Thr Trp Val Ser Met Lys Asn Val Arg Phe Leu Asp Asp Ser Ile
        1235                1240                1245            
Leu Lys Arg Arg Asp Val Gly Ser Ala Ala Phe Lys Ile Phe Leu Lys
    1250                1255                1260                
Tyr Leu Lys Lys Thr Gly Ser Lys Asn Leu Cys Ala Val Glu Leu Pro
1265                1270                1275                1280
Ser Ser Val Lys Leu Gly Phe Glu Glu Ala Gly Cys Lys Gln Ile Leu
                1285                1290                1295    
Leu Glu Asn Thr Phe Ser Glu Lys Gln Phe Phe Ser Glu Val Phe Phe
            1300                1305                1310        
Pro Asn Ile Gln Glu Ile Glu Ala Glu Leu Arg Asp Pro Leu Met Ile
        1315                1320                1325            
Phe Val Leu Asn Glu Lys Val Asp Glu Phe Ser Gly Val Leu Arg Val
    1330                1335                1340                
Thr Pro Cys Ile Pro Cys Ser Leu Glu Gly His Pro Leu Val Leu Pro
1345                1350                1355                1360
Ser Arg Leu Ile His Pro Glu Gly Arg Val Ala Lys Leu Phe Asp Ile
                1365                1370                1375    
Lys Asp Gly Arg Phe Pro Tyr Gly Ser Thr Gln Asp Tyr Leu Asn Pro
            1380                1385                1390        
Ile Ile Leu Ile Lys Leu Val Gln Leu Gly Met Ala Lys Asp Asp Ile
        1395                1400                1405            
Leu Trp Asp Asp Met Leu Glu Arg Ala Val Ser Val Ala Glu Ile Asn
    1410                1415                1420                
Lys Ser Asp His Val Ala Ala Cys Leu Arg Ser Ser Ile Leu Leu Ser
1425                1430                1435                1440
Leu Ile Asp Glu Lys Leu Lys Ile Arg Asp Pro Arg Ala Lys Asp Phe
                1445                1450                1455    
Ala Ala Lys Tyr Gln Thr Ile Arg Phe Leu Pro Phe Leu Thr Lys Pro
            1460                1465                1470        
Ala Gly Phe Ser Leu Asp Trp Lys Gly Asn Ser Phe Lys Pro Glu Thr
        1475                1480                1485            
Met Phe Ala Ala Thr Asp Leu Tyr Thr Ala Glu His Gln Asp Ile Val
    1490                1495                1500                
Cys Leu Leu Gln Pro Ile Leu Asn Glu Asn Ser His Ser Phe Arg Gly
1505                1510                1515                1520
Cys Gly Ser Val Ser Leu Ala Val Lys Glu Phe Leu Gly Leu Leu Lys
                1525                1530                1535    
Lys Pro Thr Val Asp Leu Val Ile Asn Gln Leu Lys Glu Val Ala Lys
            1540                1545                1550        
Ser Val Asp Asp Gly Ile Thr Leu Tyr Gln Glu Asn Ile Thr Asn Ala
        1555                1560                1565            
Cys Tyr Lys Tyr Leu His Glu Ala Leu Met Gln Asn Glu Ile Thr Lys
    1570                1575                1580                
Met Ser Ile Ile Asp Lys Leu Lys Pro Phe Ser Phe Ile Leu Val Glu
1585                1590                1595                1600
Asn Ala Tyr Val Asp Ser Glu Lys Val Ser Phe His Leu Asn Phe Glu
                1605                1610                1615    
Ala Ala Pro Tyr Leu Tyr Gln Leu Pro Asn Lys Tyr Lys Asn Asn Phe
            1620                1625                1630        
Arg Glu Leu Phe Glu Thr Val Gly Val Arg Gln Ser Cys Thr Val Glu
        1635                1640                1645            
Asp Phe Ala Leu Val Leu Glu Ser Ile Asp Gln Glu Arg Gly Thr Lys
    1650                1655                1660                
Gln Ile Thr Glu Glu Asn Phe Gln Leu Cys Arg Arg Ile Ile Ser Glu
1665                1670                1675                1680
Gly Ile Trp Ser Leu Ile Arg Glu Lys Lys Gln Glu Phe Cys Glu Lys
                1685                1690                1695    
Asn Tyr Gly Lys Ile Leu Leu Pro Asp Thr Asn Leu Met Leu Leu Pro
            1700                1705                1710        
Ala Lys Ser Leu Cys Tyr Asn Asp Cys Pro Trp Ile Lys Val Lys Asp
        1715                1720                1725            
Thr Thr Val Lys Tyr Cys His Ala Asp Ile Pro Arg Glu Val Ala Val
    1730                1735                1740                
Lys Leu Gly Ala Val Pro Lys Arg His Lys Ala Leu Glu Arg Tyr Ala
1745                1750                1755                1760
Ser Asn Val Cys Phe Thr Thr Leu Gly Thr Glu Phe Gly Gln Lys Glu
                1765                1770                1775    
Lys Leu Thr Ser Arg Ile Lys Ser Ile Leu Asn Ala Tyr Pro Ser Glu
            1780                1785                1790        
Lys Glu Met Leu Lys Glu Leu Leu Gln Asn Ala Asp Asp Ala Lys Ala
        1795                1800                1805            
Thr Glu Ile Cys Phe Val Phe Asp Pro Arg Gln His Pro Val Asp Arg
    1810                1815                1820                
Ile Phe Asp Asp Lys Trp Ala Pro Leu Gln Gly Pro Ala Leu Cys Val
1825                1830                1835                1840
Tyr Asn Asn Gln Pro Phe Thr Glu Asp Asp Val Arg Gly Ile Gln Asn
                1845                1850                1855    
Leu Gly Lys Gly Thr Lys Glu Gly Asn Pro Tyr Lys Thr Gly Gln Tyr
            1860                1865                1870        
Gly Ile Gly Phe Asn Ser Val Tyr His Ile Thr Asp Cys Pro Ser Phe
        1875                1880                1885            
Ile Ser Gly Asn Asp Ile Leu Cys Ile Phe Asp Pro His Ala Arg Tyr
    1890                1895                1900                
Ala Pro Gly Ala Thr Ser Ile Ser Pro Gly Arg Met Phe Arg Asp Leu
1905                1910                1915                1920
Asp Ala Asp Phe Arg Thr Gln Phe Ser Asp Val Leu Asp Leu Tyr Leu
                1925                1930                1935    
Gly Thr His Phe Lys Leu Asp Asn Cys Thr Met Phe Arg Phe Pro Leu
            1940                1945                1950        
Arg Asn Ala Glu Met Ala Lys Val Ser Glu Ile Ser Ser Val Pro Ala
        1955                1960                1965            
Ser Asp Arg Met Val Gln Asn Leu Leu Asp Lys Leu Arg Ser Asp Gly
    1970                1975                1980                
Ala Glu Leu Leu Met Phe Leu Asn His Met Glu Lys Ile Ser Ile Cys
1985                1990                1995                2000
Glu Ile Asp Lys Ser Thr Gly Ala Leu Asn Val Leu Tyr Ser Val Lys
                2005                2010                2015    
Gly Lys Ile Thr Asp Gly Asp Arg Leu Lys Arg Lys Gln Phe His Ala
            2020                2025                2030        
Ser Val Ile Asp Ser Val Thr Lys Lys Arg Gln Leu Lys Asp Ile Pro
        2035                2040                2045            
Val Gln Gln Ile Thr Tyr Thr Met Asp Thr Glu Asp Ser Glu Gly Asn
    2050                2055                2060                
Leu Thr Thr Trp Leu Ile Cys Asn Arg Ser Gly Phe Ser Ser Met Glu
2065                2070                2075                2080
Lys Val Ser Lys Ser Val Ile Ser Ala His Lys Asn Gln Asp Ile Thr
                2085                2090                2095    
Leu Phe Pro Arg Gly Gly Val Ala Ala Cys Ile Thr His Asn Tyr Lys
            2100                2105                2110        
Lys Pro His Arg Ala Phe Cys Phe Leu Pro Leu Ser Leu Glu Thr Gly
        2115                2120                2125            
Leu Pro Phe His Val Asn Gly His Phe Ala Leu Asp Ser Ala Arg Arg
    2130                2135                2140                
Asn Leu Trp Arg Asp Asp Asn Gly Val Gly Val Arg Ser Asp Trp Asn
2145                2150                2155                2160
Asn Ser Leu Met Thr Ala Leu Ile Ala Pro Ala Tyr Val Glu Leu Leu
                2165                2170                2175    
Ile Gln Leu Lys Lys Arg Tyr Phe Pro Gly Ser Asp Pro Thr Leu Ser
            2180                2185                2190        
Val Leu Gln Asn Thr Pro Ile His Val Val Lys Asp Thr Leu Lys Lys
        2195                2200                2205            
Phe Leu Ser Phe Phe Pro Val Asn Arg Leu Asp Leu Gln Pro Asp Leu
    2210                2215                2220                
Tyr Cys Leu Val Lys Ala Leu Tyr Asn Cys Ile His Glu Asp Met Lys
2225                2230                2235                2240
Arg Leu Leu Pro Val Val Arg Ala Pro Asn Ile Asp Gly Ser Asp Leu
                2245                2250                2255    
His Ser Ala Val Ile Ile Thr Trp Ile Asn Met Ser Thr Ser Asn Lys
            2260                2265                2270        
Thr Arg Pro Phe Phe Asp Asn Leu Leu Gln Asp Glu Leu Gln His Leu
        2275                2280                2285            
Lys Asn Ala Asp Tyr Asn Ile Thr Thr Arg Lys Thr Val Ala Glu Asn
    2290                2295                2300                
Val Tyr Arg Leu Lys His Leu Leu Leu Glu Ile Gly Phe Asn Leu Val
2305                2310                2315                2320
Tyr Asn Cys Asp Glu Thr Ala Asn Leu Tyr His Cys Leu Ile Asp Ala
                2325                2330                2335    
Asp Ile Pro Val Ser Tyr Val Thr Pro Ala Asp Ile Arg Ser Phe Leu
            2340                2345                2350        
Met Thr Phe Ser Ser Pro Asp Thr Asn Cys His Ile Gly Lys Leu Pro
        2355                2360                2365            
Cys Arg Leu Gln Gln Thr Asn Leu Lys Leu Phe His Ser Leu Lys Leu
    2370                2375                2380                
Leu Val Asp Tyr Cys Phe Lys Asp Ala Glu Glu Asn Glu Ile Glu Val
2385                2390                2395                2400
Glu Gly Leu Pro Leu Leu Ile Thr Leu Asp Ser Val Leu Gln Thr Phe
                2405                2410                2415    
Asp Ala Lys Arg Pro Lys Phe Leu Thr Thr Tyr His Glu Leu Ile Pro
            2420                2425                2430        
Ser Arg Lys Asp Leu Phe Met Asn Thr Leu Tyr Leu Lys Tyr Ser Asn
        2435                2440                2445            
Ile Leu Leu Asn Cys Lys Val Ala Lys Val Phe Asp Ile Ser Ser Phe
    2450                2455                2460                
Ala Asp Leu Leu Ser Ser Val Leu Pro Arg Glu Tyr Lys Thr Lys Ser
2465                2470                2475                2480
Cys Thr Lys Trp Lys Asp Asn Phe Ala Ser Glu Ser Trp Leu Lys Asn
                2485                2490                2495    
Ala Trp His Phe Ile Ser Glu Ser Val Ser Val Lys Glu Asp Gln Glu
            2500                2505                2510        
Glu Thr Lys Pro Thr Phe Asp Ile Val Val Asp Thr Leu Lys Asp Trp
        2515                2520                2525            
Ala Leu Leu Pro Gly Thr Lys Phe Thr Val Ser Ala Asn Gln Leu Val
    2530                2535                2540                
Val Pro Glu Gly Asp Val Leu Leu Pro Leu Ser Leu Met His Ile Ala
2545                2550                2555                2560
Val Phe Pro Asn Ala Gln Ser Asp Lys Val Phe His Ala Leu Met Lys
                2565                2570                2575    
Ala Gly Cys Ile Gln Leu Ala Leu Asn Lys Ile Cys Ser Lys Asp Ser
            2580                2585                2590        
Ala Phe Val Pro Leu Leu Ser Cys His Thr Ala Asn Ile Glu Ser Pro
        2595                2600                2605            
Thr Ser Ile Leu Lys Ala Leu His Tyr Met Val Gln Thr Ser Thr Phe
    2610                2615                2620                
Arg Ala Glu Lys Leu Val Glu Asn Asp Phe Glu Ala Leu Leu Met Tyr
2625                2630                2635                2640
Phe Asn Cys Asn Leu Asn His Leu Met Ser Gln Asp Asp Ile Lys Ile
                2645                2650                2655    
Leu Lys Ser Leu Pro Cys Tyr Lys Ser Ile Ser Gly Arg Tyr Val Ser
            2660                2665                2670        
Ile Gly Lys Phe Gly Thr Cys Tyr Val Leu Thr Lys Ser Ile Pro Ser
        2675                2680                2685            
Ala Glu Val Glu Lys Trp Thr Gln Ser Ser Ser Ser Ala Phe Leu Glu
    2690                2695                2700                
Glu Lys Ile His Leu Lys Glu Leu Tyr Glu Val Ile Gly Cys Val Pro
2705                2710                2715                2720
Val Asp Asp Leu Glu Val Tyr Leu Lys His Leu Leu Pro Lys Ile Glu
                2725                2730                2735    
Asn Leu Ser Tyr Asp Ala Lys Leu Glu His Leu Ile Tyr Leu Lys Asn
            2740                2745                2750        
Arg Leu Ser Ser Ala Glu Glu Leu Ser Glu Ile Lys Glu Gln Leu Phe
        2755                2760                2765            
Glu Lys Leu Glu Ser Leu Leu Ile Ile His Asp Ala Asn Ser Arg Leu
    2770                2775                2780                
Lys Gln Ala Lys His Phe Tyr Asp Arg Thr Val Arg Val Phe Glu Val
2785                2790                2795                2800
Met Leu Pro Glu Lys Leu Phe Ile Pro Asn Asp Phe Phe Lys Lys Leu
                2805                2810                2815    
Glu Gln Leu Ile Lys Pro Lys Asn His Val Thr Phe Met Thr Ser Trp
            2820                2825                2830        
Val Glu Phe Leu Arg Asn Ile Gly Leu Lys Tyr Ile Leu Ser Gln Gln
        2835                2840                2845            
Gln Leu Leu Gln Phe Ala Lys Glu Ile Ser Val Arg Ala Asn Thr Glu
    2850                2855                2860                
Asn Trp Ser Lys Glu Thr Leu Gln Asn Thr Val Asp Ile Leu Leu His
2865                2870                2875                2880
His Ile Phe Gln Glu Arg Met Asp Leu Leu Ser Gly Asn Phe Leu Lys
                2885                2890                2895    
Glu Leu Ser Leu Ile Pro Phe Leu Cys Pro Glu Arg Ala Pro Ala Glu
            2900                2905                2910        
Phe Ile Arg Phe His Pro Gln Tyr Gln Glu Val Asn Gly Thr Leu Pro
        2915                2920                2925            
Leu Ile Lys Phe Asn Gly Ala Gln Val Asn Pro Lys Phe Lys Gln Cys
    2930                2935                2940                
Asp Val Leu Gln Leu Leu Trp Thr Ser Cys Pro Ile Leu Pro Glu Lys
2945                2950                2955                2960
Ala Thr Pro Leu Ser Ile Lys Glu Gln Glu Gly Ser Asp Leu Gly Pro
                2965                2970                2975    
Gln Glu Gln Leu Glu Gln Val Leu Asn Met Leu Asn Val Asn Leu Asp
            2980                2985                2990        
Pro Pro Leu Asp Lys Val Ile Asn Asn Cys Arg Asn Ile Cys Asn Ile
        2995                3000                3005            
Thr Thr Leu Asp Glu Glu Met Val Lys Thr Arg Ala Lys Val Leu Arg
    3010                3015                3020                
Ser Ile Tyr Glu Phe Leu Ser Ala Glu Lys Arg Glu Phe Arg Phe Gln
3025                3030                3035                3040
Leu Arg Gly Val Ala Phe Val Met Val Glu Asp Gly Trp Lys Leu Leu
                3045                3050                3055    
Lys Pro Glu Glu Val Val Ile Asn Leu Glu Tyr Glu Ser Asp Phe Lys
            3060                3065                3070        
Pro Tyr Leu Tyr Lys Leu Pro Leu Glu Leu Gly Thr Phe His Gln Leu
        3075                3080                3085            
Phe Lys His Leu Gly Thr Glu Asp Ile Ile Ser Thr Lys Gln Tyr Val
    3090                3095                3100                
Glu Val Leu Ser Arg Ile Phe Lys Asn Ser Glu Gly Lys Gln Leu Asp
3105                3110                3115                3120
Pro Asn Glu Met Arg Thr Val Lys Arg Val Val Ser Gly Leu Phe Arg
                3125                3130                3135    
Ser Leu Gln Asn Asp Ser Val Lys Val Arg Ser Asp Leu Glu Asn Val
            3140                3145                3150        
Arg Asp Leu Ala Leu Tyr Leu Pro Ser Gln Asp Gly Arg Leu Val Lys
        3155                3160                3165            
Ser Ser Ile Leu Val Phe Asp Asp Ala Pro His Tyr Lys Ser Arg Ile
    3170                3175                3180                
Gln Gly Asn Ile Gly Val Gln Met Leu Val Asp Leu Ser Gln Cys Tyr
3185                3190                3195                3200
Leu Gly Lys Asp His Gly Phe His Thr Lys Leu Ile Met Leu Phe Pro
                3205                3210                3215    
Gln Lys Leu Arg Pro Arg Leu Leu Ser Ser Ile Leu Glu Glu Gln Leu
            3220                3225                3230        
Asp Glu Glu Thr Pro Lys Val Cys Gln Phe Gly Ala Leu Cys Ser Leu
        3235                3240                3245            
Gln Gly Arg Leu Gln Leu Leu Leu Ser Ser Glu Gln Phe Ile Thr Gly
    3250                3255                3260                
Leu Ile Arg Ile Met Lys His Glu Asn Asp Asn Ala Phe Leu Ala Asn
3265                3270                3275                3280
Glu Glu Lys Ala Ile Arg Leu Cys Lys Ala Leu Arg Glu Gly Leu Lys
                3285                3290                3295    
Val Ser Cys Phe Glu Lys Leu Gln Thr Thr Leu Arg Val Lys Gly Phe
            3300                3305                3310        
Asn Pro Ile Pro His Ser Arg Ser Glu Thr Phe Ala Phe Leu Lys Arg
        3315                3320                3325            
Phe Gly Asn Ala Val Ile Leu Leu Tyr Ile Gln His Ser Asp Ser Lys
    3330                3335                3340                
Asp Ile Asn Phe Leu Leu Ala Leu Ala Met Thr Leu Lys Ser Ala Thr
3345                3350                3355                3360
Asp Asn Leu Ile Ser Asp Thr Ser Tyr Leu Ile Ala Met Leu Gly Cys
                3365                3370                3375    
Asn Asp Ile Tyr Arg Ile Gly Glu Lys Leu Asp Ser Leu Gly Val Lys
            3380                3385                3390        
Tyr Asp Ser Ser Glu Pro Ser Lys Leu Glu Leu Pro Met Pro Gly Thr
        3395                3400                3405            
Pro Ile Pro Ala Glu Ile His Tyr Thr Leu Leu Met Asp Pro Met Asn
    3410                3415                3420                
Val Phe Tyr Pro Gly Glu Tyr Val Gly Tyr Leu Val Asp Ala Glu Gly
3425                3430                3435                3440
Gly Asp Ile Tyr Gly Ser Tyr Gln Pro Thr Tyr Thr Tyr Ala Ile Ile
                3445                3450                3455    
Val Gln Glu Val Glu Arg Glu Asp Ala Asp Asn Ser Ser Phe Leu Gly
            3460                3465                3470        
Lys Ile Tyr Gln Ile Asp Ile Gly Tyr Ser Glu Tyr Lys Ile Val Ser
        3475                3480                3485            
Ser Leu Asp Leu Tyr Lys Phe Ser Arg Pro Glu Glu Ser Ser Gln Ser
    3490                3495                3500                
Arg Asp Ser Ala Pro Ser Thr Pro Thr Ser Pro Thr Glu Phe Leu Thr
3505                3510                3515                3520
Pro Gly Leu Arg Ser Ile Pro Pro Leu Phe Ser Gly Arg Glu Ser His
                3525                3530                3535    
Lys Thr Ser Ser Lys His Gln Ser Pro Lys Lys Leu Lys Val Asn Ser
            3540                3545                3550        
Leu Pro Glu Ile Leu Lys Glu Val Thr Ser Val Val Glu Gln Ala Trp
        3555                3560                3565            
Lys Leu Pro Glu Ser Glu Arg Lys Lys Ile Ile Arg Arg Leu Tyr Leu
    3570                3575                3580                
Lys Trp His Pro Asp Lys Asn Pro Glu Asn His Asp Ile Ala Asn Glu
3585                3590                3595                3600
Val Phe Lys His Leu Gln Asn Glu Ile Asn Arg Leu Glu Lys Gln Ala
                3605                3610                3615    
Phe Leu Asp Gln Asn Ala Asp Arg Ala Ser Arg Arg Thr Phe Ser Thr
            3620                3625                3630        
Ser Ala Ser Arg Phe Gln Ser Asp Lys Tyr Ser Phe Gln Arg Phe Tyr
        3635                3640                3645            
Thr Ser Trp Asn Gln Glu Ala Thr Ser His Lys Ser Glu Arg Gln Gln
    3650                3655                3660                
Gln Asn Lys Glu Lys Cys Pro Pro Ser Ala Gly Gln Thr Tyr Ser Gln
3665                3670                3675                3680
Arg Phe Phe Val Pro Pro Thr Phe Lys Ser Val Gly Asn Pro Val Glu
                3685                3690                3695    
Ala Arg Arg Trp Leu Arg Gln Ala Arg Ala Asn Phe Ser Ala Ala Arg
            3700                3705                3710        
Asn Asp Leu His Lys Asn Ala Asn Glu Trp Val Cys Phe Lys Cys Tyr
        3715                3720                3725            
Leu Ser Thr Lys Leu Ala Leu Ile Ala Ala Asp Tyr Ala Val Arg Gly
    3730                3735                3740                
Lys Ser Asp Lys Asp Val Lys Pro Thr Ala Leu Ala Gln Lys Ile Glu
3745                3750                3755                3760
Glu Tyr Ser Gln Gln Leu Glu Gly Leu Thr Asn Asp Val His Thr Leu
                3765                3770                3775    
Glu Ala Tyr Gly Val Asp Ser Leu Lys Thr Arg Tyr Pro Asp Leu Leu
            3780                3785                3790        
Pro Phe Pro Gln Ile Pro Asn Asp Arg Phe Thr Ser Glu Val Ala Met
        3795                3800                3805            
Arg Val Met Glu Cys Thr Ala Cys Ile Ile Ile Lys Leu Glu Asn Phe
    3810                3815                3820                
Met Gln Gln Lys Val
3825                


<210> 850
<211> 242
<212> PRT
<213> Homo sapiens

<400> 850
Met Gly Glu Ala Ser Pro Pro Ala Pro Ala Arg Arg His Leu Leu Val
 1               5                  10                  15      
Leu Leu Leu Leu Leu Ser Thr Leu Val Ile Pro Ser Ala Ala Ala Pro
            20                  25                  30          
Ile His Asp Ala Asp Ala Gln Glu Ser Ser Leu Gly Leu Thr Gly Leu
        35                  40                  45              
Gln Ser Leu Leu Gln Gly Phe Ser Arg Leu Phe Leu Lys Gly Asn Leu
    50                  55                  60                  
Leu Arg Gly Ile Asp Ser Leu Phe Ser Ala Pro Met Asp Phe Arg Gly
65                  70                  75                  80  
Leu Pro Gly Asn Tyr His Lys Glu Glu Asn Gln Glu His Gln Leu Gly
                85                  90                  95      
Asn Asn Thr Leu Ser Ser His Leu Gln Ile Asp Lys Met Thr Asp Asn
            100                 105                 110         
Lys Thr Gly Glu Val Leu Ile Ser Glu Asn Val Val Ala Ser Ile Gln
        115                 120                 125             
Pro Ala Glu Gly Ser Phe Glu Gly Asp Leu Lys Val Pro Arg Met Glu
    130                 135                 140                 
Glu Lys Glu Ala Leu Val Pro Ile Gln Lys Ala Thr Asp Ser Phe His
145                 150                 155                 160 
Thr Glu Leu His Pro Arg Val Ala Phe Trp Ile Ile Lys Leu Pro Arg
                165                 170                 175     
Arg Arg Ser His Gln Asp Ala Leu Glu Gly Gly His Trp Leu Ser Glu
            180                 185                 190         
Lys Arg His Arg Leu Gln Ala Ile Arg Asp Gly Leu Arg Lys Gly Thr
        195                 200                 205             
His Lys Asp Val Leu Glu Glu Gly Thr Glu Ser Ser Ser His Ser Arg
    210                 215                 220                 
Leu Ser Pro Arg Lys Thr His Leu Leu Tyr Ile Leu Arg Pro Ser Arg
225                 230                 235                 240 
Gln Leu
        


<210> 851
<211> 963
<212> PRT
<213> Homo sapiens

<400> 851
Met Ala Ala Gln Arg Ile Arg Ala Ala Asn Ser Asn Gly Leu Pro Arg
 1               5                  10                  15      
Cys Lys Ser Glu Gly Thr Leu Ile Asp Leu Ser Glu Gly Phe Ser Glu
            20                  25                  30          
Thr Ser Phe Asn Asp Ile Lys Val Pro Ser Pro Ser Ala Leu Leu Val
        35                  40                  45              
Asp Asn Pro Thr Pro Phe Gly Asn Ala Lys Glu Val Ile Ala Ile Lys
    50                  55                  60                  
Asp Tyr Cys Pro Thr Asn Phe Thr Thr Leu Lys Phe Ser Lys Gly Asp
65                  70                  75                  80  
His Leu Tyr Val Leu Asp Thr Ser Gly Gly Glu Trp Trp Tyr Ala His
                85                  90                  95      
Asn Thr Thr Glu Met Gly Tyr Ile Pro Ser Ser Tyr Val Gln Pro Leu
            100                 105                 110         
Asn Tyr Arg Asn Ser Thr Leu Ser Asp Ser Gly Met Ile Asp Asn Leu
        115                 120                 125             
Pro Asp Ser Pro Asp Glu Val Ala Lys Glu Leu Glu Leu Leu Gly Gly
    130                 135                 140                 
Trp Thr Asp Asp Lys Lys Val Pro Gly Arg Met Tyr Ser Asn Asn Pro
145                 150                 155                 160 
Phe Trp Asn Gly Val Gln Thr Asn Pro Phe Leu Asn Gly Asn Val Pro
                165                 170                 175     
Val Met Pro Ser Leu Asp Glu Leu Asn Pro Lys Ser Thr Val Asp Leu
            180                 185                 190         
Leu Leu Phe Asp Ala Gly Thr Ser Ser Phe Thr Glu Ser Ser Ser Ala
        195                 200                 205             
Thr Thr Asn Ser Thr Gly Asn Ile Phe Asp Glu Leu Pro Val Thr Asn
    210                 215                 220                 
Gly Leu His Ala Glu Pro Pro Val Arg Arg Asp Asn Pro Phe Phe Arg
225                 230                 235                 240 
Ser Lys Arg Ser Tyr Ser Leu Ser Glu Leu Ser Val Leu Gln Ala Lys
                245                 250                 255     
Ser Asp Ala Pro Thr Ser Ser Ser Phe Phe Thr Gly Leu Lys Ser Pro
            260                 265                 270         
Ala Pro Glu Gln Phe Gln Ser Arg Glu Asp Phe Arg Thr Ala Trp Leu
        275                 280                 285             
Asn His Arg Lys Leu Ala Arg Ser Cys His Asp Leu Asp Leu Leu Gly
    290                 295                 300                 
Gln Ser Pro Gly Trp Gly Gln Thr Gln Ala Val Glu Thr Asn Ile Val
305                 310                 315                 320 
Cys Lys Leu Asp Ser Ser Gly Gly Ala Val Gln Leu Pro Asp Thr Ser
                325                 330                 335     
Ile Ser Ile His Val Pro Glu Gly His Val Ala Pro Gly Glu Thr Gln
            340                 345                 350         
Gln Ile Ser Met Lys Ala Leu Leu Asp Pro Pro Leu Glu Leu Asn Ser
        355                 360                 365             
Asp Arg Ser Cys Ser Ile Ser Pro Val Leu Glu Val Lys Leu Ser Asn
    370                 375                 380                 
Leu Glu Val Lys Thr Ser Ile Ile Leu Glu Met Lys Val Ser Ala Glu
385                 390                 395                 400 
Ile Lys Asn Asp Leu Phe Ser Lys Ser Thr Val Gly Leu Gln Cys Leu
                405                 410                 415     
Arg Ser Asp Ser Lys Glu Gly Pro Tyr Val Ser Val Pro Leu Asn Cys
            420                 425                 430         
Ser Cys Gly Asp Thr Val Gln Ala Gln Leu His Asn Leu Glu Pro Cys
        435                 440                 445             
Met Tyr Val Ala Val Val Ala His Gly Pro Ser Ile Leu Tyr Pro Ser
    450                 455                 460                 
Thr Val Trp Asp Phe Ile Asn Lys Lys Val Thr Val Gly Leu Tyr Gly
465                 470                 475                 480 
Pro Lys His Ile His Pro Ser Phe Lys Thr Val Val Thr Ile Phe Gly
                485                 490                 495     
His Asp Cys Ala Pro Lys Thr Leu Leu Val Ser Glu Val Thr Arg Gln
            500                 505                 510         
Ala Pro Asn Pro Ala Pro Val Ala Leu Gln Leu Trp Gly Lys His Gln
        515                 520                 525             
Phe Val Leu Ser Arg Pro Gln Asp Leu Lys Val Cys Met Phe Ser Asn
    530                 535                 540                 
Met Thr Asn Tyr Glu Val Lys Ala Ser Glu Gln Ala Lys Val Val Arg
545                 550                 555                 560 
Gly Phe Gln Leu Lys Leu Gly Lys Val Ser Arg Leu Ile Phe Pro Ile
                565                 570                 575     
Thr Ser Gln Asn Pro Asn Glu Leu Ser Asp Phe Thr Leu Arg Val Gln
            580                 585                 590         
Val Lys Asp Asp Gln Glu Ala Ile Leu Thr Gln Phe Cys Val Gln Thr
        595                 600                 605             
Pro Gln Pro Pro Pro Lys Ser Ala Ile Lys Pro Ser Gly Gln Arg Arg
    610                 615                 620                 
Phe Leu Lys Lys Asn Glu Val Gly Lys Ile Ile Leu Ser Pro Phe Ala
625                 630                 635                 640 
Thr Thr Thr Lys Tyr Pro Thr Phe Gln Asp Arg Pro Val Ser Ser Leu
                645                 650                 655     
Lys Phe Gly Lys Leu Leu Lys Thr Val Val Arg Gln Asn Lys Asn His
            660                 665                 670         
Tyr Leu Leu Glu Tyr Lys Lys Gly Asp Gly Ile Ala Leu Leu Ser Glu
        675                 680                 685             
Glu Arg Val Arg Leu Arg Gly Gln Leu Trp Thr Lys Glu Trp Tyr Ile
    690                 695                 700                 
Gly Tyr Tyr Gln Gly Arg Val Gly Leu Val His Thr Lys Asn Val Leu
705                 710                 715                 720 
Val Val Gly Arg Ala Arg Pro Ser Leu Cys Ser Gly Pro Glu Leu Ser
                725                 730                 735     
Thr Ser Val Leu Leu Glu Gln Ile Leu Arg Pro Cys Lys Phe Leu Thr
            740                 745                 750         
Tyr Ile Tyr Ala Ser Val Arg Thr Leu Leu Met Glu Asn Ile Ser Ser
        755                 760                 765             
Trp Arg Ser Phe Ala Asp Ala Leu Gly Tyr Val Asn Leu Pro Leu Thr
    770                 775                 780                 
Phe Phe Cys Arg Ala Glu Leu Asp Ser Glu Pro Glu Arg Val Ala Ser
785                 790                 795                 800 
Val Leu Glu Lys Leu Lys Glu Asp Cys Asn Asn Thr Glu Asn Lys Glu
                805                 810                 815     
Arg Lys Ser Phe Gln Lys Glu Leu Val Met Ala Leu Leu Lys Met Asp
            820                 825                 830         
Cys Gln Gly Leu Val Val Arg Leu Ile Gln Asp Phe Val Leu Leu Thr
        835                 840                 845             
Thr Ala Val Glu Val Ala Gln Arg Trp Arg Glu Leu Ala Glu Lys Leu
    850                 855                 860                 
Ala Lys Val Ser Lys Gln Gln Met Asp Ala Tyr Glu Ser Pro His Arg
865                 870                 875                 880 
Asp Arg Asn Gly Val Val Asp Ser Glu Ala Met Trp Lys Pro Ala Tyr
                885                 890                 895     
Asp Phe Leu Leu Thr Trp Ser His Gln Ile Gly Asp Ser Tyr Arg Asp
            900                 905                 910         
Val Ile Gln Glu Leu His Leu Gly Leu Asp Lys Met Lys Asn Pro Ile
        915                 920                 925             
Thr Lys Arg Trp Lys His Leu Thr Gly Thr Leu Ile Leu Val Asn Ser
    930                 935                 940                 
Leu Asp Val Leu Arg Ala Ala Ala Phe Ser Pro Ala Asp Gln Asp Asp
945                 950                 955                 960 
Phe Val Ile
            


<210> 852
<211> 675
<212> PRT
<213> Homo sapiens

<400> 852
Met Ala Ala Ala Lys Val Ala Leu Thr Lys Arg Ala Asp Pro Ala Glu
 1               5                  10                  15      
Leu Arg Thr Ile Phe Leu Lys Tyr Ala Ser Ile Glu Lys Asn Gly Glu
            20                  25                  30          
Phe Phe Met Ser Pro Asn Asp Phe Val Thr Arg Tyr Leu Asn Ile Phe
        35                  40                  45              
Gly Glu Ser Gln Pro Asn Pro Lys Thr Val Glu Leu Leu Ser Gly Val
    50                  55                  60                  
Val Asp Gln Thr Lys Asp Gly Leu Ile Ser Phe Gln Glu Phe Val Ala
65                  70                  75                  80  
Phe Glu Ser Val Leu Cys Ala Pro Asp Ala Leu Phe Met Val Ala Phe
                85                  90                  95      
Gln Leu Phe Asp Lys Ala Gly Lys Gly Glu Val Thr Phe Glu Asp Val
            100                 105                 110         
Lys Gln Val Phe Gly Gln Thr Thr Ile His Gln His Ile Pro Phe Asn
        115                 120                 125             
Trp Asp Ser Glu Phe Val Gln Leu His Phe Gly Lys Glu Arg Lys Arg
    130                 135                 140                 
His Leu Thr Tyr Ala Glu Phe Thr Gln Phe Leu Leu Glu Ile Gln Leu
145                 150                 155                 160 
Glu His Ala Lys Gln Ala Phe Val Gln Arg Asp Asn Ala Arg Thr Gly
                165                 170                 175     
Arg Val Thr Ala Ile Asp Phe Arg Asp Ile Met Val Thr Ile Arg Pro
            180                 185                 190         
His Val Leu Thr Pro Phe Val Glu Glu Cys Leu Val Ala Ala Ala Gly
        195                 200                 205             
Gly Thr Thr Ser His Gln Val Ser Phe Ser Tyr Phe Asn Gly Phe Asn
    210                 215                 220                 
Ser Leu Leu Asn Asn Met Glu Leu Ile Arg Lys Ile Tyr Ser Thr Leu
225                 230                 235                 240 
Ala Gly Thr Arg Lys Asp Val Glu Val Thr Lys Glu Glu Phe Val Leu
                245                 250                 255     
Ala Ala Gln Lys Phe Gly Gln Val Thr Pro Met Glu Val Asp Ile Leu
            260                 265                 270         
Phe Gln Leu Ala Asp Leu Tyr Glu Pro Arg Gly Arg Met Thr Leu Ala
        275                 280                 285             
Asp Ile Glu Arg Ile Ala Pro Leu Glu Glu Gly Thr Leu Pro Phe Asn
    290                 295                 300                 
Leu Ala Glu Ala Gln Arg Gln Lys Ala Ser Gly Asp Ser Ala Arg Pro
305                 310                 315                 320 
Val Leu Leu Gln Val Ala Glu Ser Ala Tyr Arg Phe Gly Leu Gly Ser
                325                 330                 335     
Val Ala Gly Ala Val Gly Ala Thr Ala Val Tyr Pro Ile Asp Leu Val
            340                 345                 350         
Lys Thr Arg Met Gln Asn Gln Arg Ser Thr Gly Ser Phe Val Gly Glu
        355                 360                 365             
Leu Met Tyr Lys Asn Ser Phe Asp Cys Phe Lys Lys Val Leu Arg Tyr
    370                 375                 380                 
Glu Gly Phe Phe Gly Leu Tyr Arg Gly Leu Leu Pro Gln Leu Leu Gly
385                 390                 395                 400 
Val Ala Pro Glu Lys Ala Ile Lys Leu Thr Val Asn Asp Phe Val Arg
                405                 410                 415     
Asp Lys Phe Met His Lys Asp Gly Ser Val Pro Leu Ala Ala Glu Ile
            420                 425                 430         
Leu Ala Gly Gly Cys Ala Gly Gly Ser Gln Val Ile Phe Thr Asn Pro
        435                 440                 445             
Leu Glu Ile Val Lys Ile Arg Leu Gln Val Ala Gly Glu Ile Thr Thr
    450                 455                 460                 
Gly Pro Arg Val Ser Ala Leu Ser Val Val Arg Asp Leu Gly Phe Phe
465                 470                 475                 480 
Gly Ile Tyr Lys Gly Ala Lys Ala Cys Phe Leu Arg Asp Ile Pro Phe
                485                 490                 495     
Ser Ala Ile Tyr Phe Pro Cys Tyr Ala His Val Lys Ala Ser Phe Ala
            500                 505                 510         
Asn Glu Asp Gly Gln Val Ser Pro Gly Ser Leu Leu Leu Ala Gly Ala
        515                 520                 525             
Ile Ala Gly Met Pro Ala Ala Ser Leu Val Thr Pro Ala Asp Val Ile
    530                 535                 540                 
Lys Thr Arg Leu Gln Val Ala Ala Arg Ala Gly Gln Thr Thr Tyr Ser
545                 550                 555                 560 
Gly Val Ile Asp Cys Phe Arg Lys Ile Leu Arg Glu Glu Gly Pro Lys
                565                 570                 575     
Ala Leu Trp Lys Gly Ala Gly Ala Arg Val Phe Arg Ser Ser Pro Gln
            580                 585                 590         
Phe Gly Val Thr Leu Leu Thr Tyr Glu Leu Leu Gln Arg Trp Phe Tyr
        595                 600                 605             
Ile Asp Phe Gly Gly Val Lys Pro Met Gly Ser Glu Pro Val Pro Lys
    610                 615                 620                 
Ser Arg Ile Asn Leu Pro Ala Pro Asn Pro Asp His Val Gly Gly Tyr
625                 630                 635                 640 
Lys Leu Ala Val Ala Thr Phe Ala Gly Ile Glu Asn Lys Phe Gly Leu
                645                 650                 655     
Tyr Leu Pro Leu Phe Lys Pro Ser Val Ser Thr Ser Lys Ala Ile Gly
            660                 665                 670         
Gly Gly Pro
        675 


<210> 853
<211> 383
<212> PRT
<213> Homo sapiens

<400> 853
Met Glu Arg Arg Ala Arg Ser Ser Ser Arg Glu Ser Arg Gly Arg Gly
 1               5                  10                  15      
Gly Arg Thr Pro His Lys Glu Asn Lys Arg Ala Lys Ala Glu Arg Ser
            20                  25                  30          
Gly Gly Gly Arg Gly Arg Gln Glu Ala Gly Pro Glu Pro Ser Gly Ser
        35                  40                  45              
Gly Arg Ala Gly Thr Pro Gly Glu Pro Arg Ala Pro Ala Ala Thr Val
    50                  55                  60                  
Val Asp Val Asp Glu Val Arg Gly Ser Gly Glu Glu Gly Thr Glu Val
65                  70                  75                  80  
Val Ala Leu Leu Glu Ser Glu Arg Pro Glu Glu Gly Thr Lys Ser Ser
                85                  90                  95      
Gly Leu Gly Ala Cys Glu Trp Leu Leu Val Leu Ile Ser Leu Leu Phe
            100                 105                 110         
Ile Ile Met Thr Phe Pro Phe Ser Ile Trp Phe Cys Val Lys Val Val
        115                 120                 125             
Gln Glu Tyr Glu Arg Val Ile Ile Phe Arg Leu Gly His Leu Leu Pro
    130                 135                 140                 
Gly Arg Ala Lys Gly Pro Gly Leu Phe Phe Phe Leu Pro Cys Leu Asp
145                 150                 155                 160 
Thr Tyr His Lys Val Asp Leu Arg Leu Gln Thr Leu Glu Ile Pro Phe
                165                 170                 175     
His Glu Ile Val Thr Lys Asp Met Phe Ile Met Glu Ile Asp Ala Ile
            180                 185                 190         
Cys Tyr Tyr Arg Met Glu Asn Ala Ser Leu Leu Leu Ser Ser Leu Ala
        195                 200                 205             
His Val Ser Lys Ala Val Gln Phe Leu Val Gln Thr Thr Met Lys Arg
    210                 215                 220                 
Leu Leu Ala His Arg Ser Leu Thr Glu Ile Leu Leu Glu Arg Lys Ser
225                 230                 235                 240 
Ile Ala Gln Asp Ala Lys Val Ala Leu Asp Ser Val Thr Cys Ile Trp
                245                 250                 255     
Gly Ile Lys Val Glu Arg Ile Glu Ile Lys Asp Val Arg Leu Pro Ala
            260                 265                 270         
Gly Leu Gln His Ser Leu Ala Val Glu Ala Glu Ala Gln Arg Gln Ala
        275                 280                 285             
Lys Val Arg Met Ile Ala Ala Glu Ala Glu Lys Ala Ala Ser Glu Ser
    290                 295                 300                 
Leu Arg Met Ala Ala Glu Ile Leu Ser Gly Thr Pro Ala Ala Val Gln
305                 310                 315                 320 
Leu Arg Tyr Leu His Thr Leu Gln Ser Leu Ser Thr Glu Lys Pro Ser
                325                 330                 335     
Thr Val Val Leu Pro Leu Pro Phe Asp Leu Leu Asn Cys Leu Ser Ser
            340                 345                 350         
Pro Ser Asn Arg Thr Gln Gly Ser Leu Pro Phe Pro Ser Pro Ser Lys
        355                 360                 365             
Pro Val Glu Pro Leu Asn Pro Lys Lys Lys Asp Ser Pro Met Leu
    370                 375                 380             


<210> 854
<211> 127
<212> PRT
<213> Homo sapiens

<400> 854
Met Ser Ala Ala Gly Ala Arg Gly Leu Arg Ala Thr Tyr His Arg Leu
 1               5                  10                  15      
Leu Asp Lys Val Glu Leu Met Leu Pro Glu Lys Leu Arg Pro Leu Tyr
            20                  25                  30          
Asn His Pro Ala Gly Pro Arg Thr Val Phe Phe Trp Ala Pro Ile Met
        35                  40                  45              
Lys Trp Gly Leu Val Cys Ala Gly Leu Ala Asp Met Ala Arg Pro Ala
    50                  55                  60                  
Glu Lys Leu Ser Thr Ala Gln Ser Ala Val Leu Met Ala Thr Gly Phe
65                  70                  75                  80  
Ile Trp Ser Arg Tyr Ser Leu Val Ile Ile Pro Lys Asn Trp Ser Leu
                85                  90                  95      
Phe Ala Val Asn Phe Phe Val Gly Ala Ala Gly Ala Ser Gln Leu Phe
            100                 105                 110         
Arg Ile Trp Arg Tyr Asn Gln Glu Leu Lys Ala Lys Ala His Lys
        115                 120                 125         


<210> 855
<211> 127
<212> PRT
<213> Homo sapiens

<400> 855
Met Ser Ala Ala Gly Ala Arg Gly Leu Arg Ala Thr Tyr His Arg Leu
 1               5                  10                  15      
Leu Asp Lys Val Glu Leu Met Leu Pro Glu Lys Leu Arg Pro Leu Tyr
            20                  25                  30          
Asn His Pro Ala Gly Pro Arg Thr Val Phe Phe Trp Ala Pro Ile Met
        35                  40                  45              
Lys Trp Gly Leu Val Cys Ala Gly Leu Ala Asp Met Ala Arg Pro Ala
    50                  55                  60                  
Glu Lys Leu Ser Thr Ala Gln Ser Ala Val Leu Met Ala Thr Gly Phe
65                  70                  75                  80  
Ile Trp Ser Arg Tyr Ser Leu Val Ile Ile Pro Lys Asn Trp Ser Leu
                85                  90                  95      
Phe Ala Val Asn Phe Phe Val Gly Ala Ala Gly Ala Ser Gln Leu Phe
            100                 105                 110         
Arg Ile Trp Arg Tyr Asn Gln Glu Leu Lys Ala Lys Ala His Lys
        115                 120                 125         


<210> 856
<211> 184
<212> PRT
<213> Homo sapiens

<400> 856
Met Arg Glu Tyr Lys Leu Val Val Leu Gly Ser Gly Gly Val Gly Lys
 1               5                  10                  15      
Ser Ala Leu Thr Val Gln Phe Val Gln Gly Ile Phe Val Glu Lys Tyr
            20                  25                  30          
Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Glu Val Asp Ala
        35                  40                  45              
Gln Gln Cys Met Leu Glu Ile Leu Asp Thr Ala Gly Thr Glu Gln Phe
    50                  55                  60                  
Thr Ala Met Arg Asp Leu Tyr Met Lys Asn Gly Gln Gly Phe Ala Leu
65                  70                  75                  80  
Val Tyr Ser Ile Thr Ala Gln Ser Thr Phe Asn Asp Leu Gln Asp Leu
                85                  90                  95      
Arg Glu Gln Ile Leu Arg Val Lys Asp Thr Asp Asp Val Pro Met Ile
            100                 105                 110         
Leu Val Gly Asn Lys Cys Asp Leu Glu Asp Glu Arg Val Val Gly Lys
        115                 120                 125             
Glu Gln Gly Gln Asn Leu Ala Arg Gln Trp Asn Asn Cys Ala Phe Leu
    130                 135                 140                 
Glu Ser Ser Ala Lys Ser Lys Ile Asn Val Asn Glu Ile Phe Tyr Asp
145                 150                 155                 160 
Leu Val Arg Gln Ile Asn Arg Lys Thr Pro Val Pro Gly Lys Ala Arg
                165                 170                 175     
Lys Lys Ser Ser Cys Gln Leu Leu
            180                 


<210> 857
<211> 196
<212> PRT
<213> Homo sapiens

<400> 857
Met Phe Ile Gln Thr Gln Asp Thr Pro Asn Pro Asn Ser Leu Lys Phe
 1               5                  10                  15      
Ile Pro Gly Lys Pro Val Leu Glu Thr Arg Thr Met Asp Phe Pro Thr
            20                  25                  30          
Pro Ala Ala Ala Phe Arg Ser Pro Leu Ala Arg Gln Leu Phe Arg Ile
        35                  40                  45              
Glu Gly Val Lys Ser Val Phe Phe Gly Pro Asp Phe Ile Thr Val Thr
    50                  55                  60                  
Lys Glu Asn Glu Glu Leu Asp Trp Asn Leu Leu Lys Pro Asp Ile Tyr
65                  70                  75                  80  
Ala Thr Ile Met Asp Phe Phe Ala Ser Gly Leu Pro Leu Val Thr Glu
                85                  90                  95      
Glu Thr Pro Ser Gly Glu Ala Gly Ser Glu Glu Asp Asp Glu Val Val
            100                 105                 110         
Ala Met Ile Lys Glu Leu Leu Asp Thr Arg Ile Arg Pro Thr Val Gln
        115                 120                 125             
Glu Asp Gly Gly Asp Val Ile Tyr Lys Gly Phe Glu Asp Gly Ile Val
    130                 135                 140                 
Gln Leu Lys Leu Gln Gly Ser Cys Thr Ser Cys Pro Ser Ser Ile Ile
145                 150                 155                 160 
Thr Leu Lys Asn Gly Ile Gln Asn Met Leu Gln Phe Tyr Ile Pro Glu
                165                 170                 175     
Val Glu Gly Val Glu Gln Val Met Asp Asp Glu Ser Asp Glu Lys Glu
            180                 185                 190         
Ala Asn Ser Pro
        195     


<210> 858
<211> 106
<212> PRT
<213> Homo sapiens

<400> 858
Met Ala Ser Ser Gly Ala Gly Asp Pro Leu Asp Ser Lys Arg Gly Glu
 1               5                  10                  15      
Ala Pro Phe Ala Gln Arg Ile Asp Pro Thr Arg Glu Lys Leu Thr Pro
            20                  25                  30          
Glu Gln Leu His Ser Met Arg Gln Ala Glu Leu Ala Gln Trp Gln Lys
        35                  40                  45              
Val Leu Pro Arg Arg Arg Thr Arg Asn Ile Val Thr Gly Leu Gly Ile
    50                  55                  60                  
Gly Ala Leu Val Leu Ala Ile Tyr Gly Tyr Thr Phe Tyr Ser Ile Ser
65                  70                  75                  80  
Gln Glu Arg Phe Leu Asp Glu Leu Glu Asp Glu Ala Lys Ala Ala Arg
                85                  90                  95      
Ala Arg Ala Leu Ala Arg Ala Ser Gly Ser
            100                 105     


<210> 859
<211> 106
<212> PRT
<213> Homo sapiens

<400> 859
Met Ala Ser Ser Gly Ala Gly Asp Pro Leu Asp Ser Lys Arg Gly Glu
 1               5                  10                  15      
Ala Pro Phe Ala Gln Arg Ile Asp Pro Thr Arg Glu Lys Leu Thr Pro
            20                  25                  30          
Glu Gln Leu His Ser Met Arg Gln Ala Glu Leu Ala Gln Trp Gln Lys
        35                  40                  45              
Val Leu Pro Arg Arg Arg Thr Arg Asn Ile Val Thr Gly Leu Gly Ile
    50                  55                  60                  
Gly Ala Leu Val Leu Ala Ile Tyr Gly Tyr Thr Phe Tyr Ser Ile Ser
65                  70                  75                  80  
Gln Glu Arg Phe Leu Asp Glu Leu Glu Asp Glu Ala Lys Ala Ala Arg
                85                  90                  95      
Ala Arg Ala Leu Ala Arg Ala Ser Gly Ser
            100                 105     


<210> 860
<211> 188
<212> PRT
<213> Homo sapiens

<400> 860
Met Ala Val Ala Asp Leu Ala Leu Ile Pro Asp Val Asp Ile Asp Ser
 1               5                  10                  15      
Asp Gly Val Phe Lys Tyr Val Leu Ile Arg Val His Ser Ala Pro Arg
            20                  25                  30          
Ser Gly Leu Arg Leu Gln Arg Ala Arg Arg Ser Cys Ala Ala Thr Ser
        35                  40                  45              
Gly Leu Ser Thr Met Arg Thr Ser Thr Thr Lys Cys Arg Ala Thr Cys
    50                  55                  60                  
Arg Ser Lys Ala Ala Thr Val Ser Val Trp Ala Ala Gly Ala Ser Pro
65                  70                  75                  80  
Thr Arg Val Arg Thr Arg Arg Phe Thr Cys Thr Ala Ile Pro Trp Pro
                85                  90                  95      
Met Val Leu Pro Ser Thr Pro Phe Gln Leu Arg Lys Ser Lys Pro Ser
            100                 105                 110         
Thr Pro Thr Thr Arg Ser Pro Gly Leu Thr Thr Ala Thr Glu His Ser
        115                 120                 125             
Gln Pro Gly Ala Cys Cys Leu Gln Gln Pro Leu Gln Ser Pro Ala Phe
    130                 135                 140                 
Ala Cys Thr Pro Leu Ala Gly Leu Ala Leu Pro Ala Pro Ala Ala Ala
145                 150                 155                 160 
Ser Gly Asp Val Leu Ser Thr Arg Pro Trp Arg Gln Ala Ser Leu Ala
                165                 170                 175     
Thr Glu Leu Asn Val Leu Pro His Leu Pro Ala Ser
            180                 185             


<210> 861
<211> 903
<212> PRT
<213> Homo sapiens

<400> 861
Met Ala Ser Val Trp Gln Arg Leu Gly Phe Tyr Ala Ser Leu Leu Lys
 1               5                  10                  15      
Arg Gln Leu Asn Gly Gly Pro Asp Val Ile Lys Trp Glu Arg Arg Val
            20                  25                  30          
Ile Pro Gly Cys Thr Arg Ser Ile Tyr Ser Ala Thr Gly Lys Trp Thr
        35                  40                  45              
Lys Glu Tyr Thr Leu Gln Thr Arg Lys Asp Val Glu Lys Trp Trp His
    50                  55                  60                  
Gln Arg Ile Lys Glu Gln Ala Ser Lys Ile Ser Glu Ala Asp Lys Ser
65                  70                  75                  80  
Lys Pro Lys Phe Tyr Val Leu Ser Met Phe Pro Tyr Pro Ser Gly Lys
                85                  90                  95      
Leu His Met Gly His Val Arg Val Tyr Thr Ile Ser Asp Thr Ile Ala
            100                 105                 110         
Arg Phe Gln Lys Met Arg Gly Met Gln Val Ile Asn Pro Met Gly Trp
        115                 120                 125             
Asp Ala Phe Gly Leu Pro Ala Glu Asn Ala Ala Val Glu Arg Asn Leu
    130                 135                 140                 
His Pro Gln Ser Trp Thr Gln Ser Asn Ile Lys His Met Arg Lys Gln
145                 150                 155                 160 
Leu Asp Arg Leu Gly Leu Cys Phe Ser Trp Asp Arg Glu Ile Thr Thr
                165                 170                 175     
Cys Leu Pro Asp Tyr Tyr Lys Trp Thr Gln Tyr Leu Phe Ile Lys Leu
            180                 185                 190         
Tyr Glu Ala Gly Leu Ala Tyr Gln Lys Glu Ala Leu Val Asn Trp Asp
        195                 200                 205             
Pro Val Asp Gln Thr Val Leu Ala Asn Glu Gln Val Asp Glu His Gly
    210                 215                 220                 
Cys Ser Trp Arg Ser Gly Ala Lys Val Glu Gln Lys Tyr Leu Arg Gln
225                 230                 235                 240 
Trp Phe Ile Lys Thr Thr Ala Tyr Ala Lys Ala Met Gln Asp Ala Leu
                245                 250                 255     
Ala Asp Leu Pro Glu Trp Tyr Gly Ile Lys Gly Met Gln Ala His Trp
            260                 265                 270         
Ile Gly Asp Cys Val Gly Cys His Leu Asp Phe Thr Leu Lys Val His
        275                 280                 285             
Gly Gln Ala Thr Gly Glu Lys Leu Thr Ala Tyr Thr Ala Thr Pro Glu
    290                 295                 300                 
Ala Ile Tyr Gly Thr Ser His Val Ala Ile Ser Pro Ser His Arg Leu
305                 310                 315                 320 
Leu His Gly His Ser Ser Leu Lys Glu Ala Leu Arg Met Ala Leu Val
                325                 330                 335     
Pro Gly Lys Asp Cys Leu Thr Pro Val Met Ala Val Asn Met Leu Thr
            340                 345                 350         
Gln Gln Glu Val Pro Val Val Ile Leu Ala Lys Ala Asp Leu Glu Gly
        355                 360                 365             
Ser Leu Asp Ser Lys Ile Gly Ile Pro Ser Thr Ser Ser Glu Asp Thr
    370                 375                 380                 
Ile Leu Ala Gln Thr Leu Gly Leu Ala Tyr Ser Glu Val Ile Glu Thr
385                 390                 395                 400 
Leu Pro Asp Gly Thr Glu Arg Leu Ser Ser Ser Ala Glu Phe Thr Gly
                405                 410                 415     
Met Thr Arg Gln Asp Ala Phe Leu Ala Leu Thr Gln Lys Ala Arg Gly
            420                 425                 430         
Lys Arg Val Gly Gly Asp Val Thr Ser Asp Lys Leu Lys Asp Trp Leu
        435                 440                 445             
Ile Ser Arg Gln Arg Tyr Trp Gly Thr Pro Ile Pro Ile Val His Cys
    450                 455                 460                 
Pro Val Cys Gly Pro Thr Pro Val Pro Leu Glu Asp Leu Pro Val Thr
465                 470                 475                 480 
Leu Pro Asn Ile Ala Ser Phe Thr Gly Lys Gly Gly Pro Pro Leu Ala
                485                 490                 495     
Met Ala Ser Glu Trp Val Asn Cys Ser Cys Pro Arg Cys Lys Gly Ala
            500                 505                 510         
Ala Lys Arg Glu Thr Asp Thr Met Asp Thr Phe Val Asp Ser Ala Trp
        515                 520                 525             
Tyr Tyr Phe Arg Tyr Thr Asp Pro His Asn Pro His Ser Pro Phe Asn
    530                 535                 540                 
Thr Ala Val Ala Asp Tyr Trp Met Pro Val Asp Leu Tyr Ile Gly Gly
545                 550                 555                 560 
Lys Glu His Ala Val Met His Leu Phe Tyr Ala Arg Phe Phe Ser His
                565                 570                 575     
Phe Cys His Asp Gln Lys Met Val Lys His Arg Glu Pro Phe His Lys
            580                 585                 590         
Leu Leu Ala Gln Gly Leu Ile Lys Gly Gln Thr Phe Arg Leu Pro Ser
        595                 600                 605             
Gly Gln Tyr Leu Gln Arg Glu Glu Val Asp Leu Thr Gly Ser Val Pro
    610                 615                 620                 
Val His Ala Lys Thr Lys Glu Lys Leu Glu Val Thr Trp Glu Lys Met
625                 630                 635                 640 
Ser Lys Ser Lys His Asn Gly Val Asp Pro Glu Glu Val Val Glu Gln
                645                 650                 655     
Tyr Gly Ile Asp Thr Ile Arg Leu Tyr Ile Leu Phe Ala Ala Pro Pro
            660                 665                 670         
Glu Lys Asp Ile Leu Trp Asp Val Lys Thr Asp Ala Leu Pro Gly Val
        675                 680                 685             
Leu Arg Trp Gln Gln Arg Leu Trp Thr Leu Thr Thr Arg Phe Ile Glu
    690                 695                 700                 
Ala Arg Ala Ser Gly Lys Ser Pro Gln Pro Gln Leu Leu Ser Asn Lys
705                 710                 715                 720 
Glu Lys Ala Glu Ala Arg Lys Leu Trp Glu Tyr Lys Asn Ser Val Ile
                725                 730                 735     
Ser Gln Val Thr Thr His Phe Thr Glu Asp Phe Ser Leu Asn Ser Ala
            740                 745                 750         
Ile Ser Gln Leu Met Gly Leu Ser Asn Ala Leu Ser Gln Ala Ser Gln
        755                 760                 765             
Ser Val Ile Leu His Ser Pro Glu Phe Glu Asp Ala Leu Cys Ala Leu
    770                 775                 780                 
Met Val Met Ala Ala Pro Leu Ala Pro His Val Thr Ser Glu Ile Trp
785                 790                 795                 800 
Ala Gly Leu Ala Leu Val Pro Arg Lys Leu Cys Ala His Tyr Thr Trp
                805                 810                 815     
Asp Ala Ser Val Leu Leu Gln Ala Trp Pro Ala Val Asp Pro Glu Phe
            820                 825                 830         
Leu Gln Gln Pro Glu Val Val Gln Met Ala Val Leu Ile Asn Asn Lys
        835                 840                 845             
Ala Cys Gly Lys Ile Pro Val Pro Gln Gln Val Ala Arg Asp Gln Asp
    850                 855                 860                 
Lys Val His Glu Phe Val Leu Gln Ser Glu Leu Gly Val Arg Leu Leu
865                 870                 875                 880 
Gln Gly Arg Ser Ile Lys Lys Ser Phe Leu Ser Pro Arg Thr Ala Leu
                885                 890                 895     
Ile Asn Phe Leu Val Gln Asp
            900             


<210> 862
<211> 903
<212> PRT
<213> Homo sapiens

<400> 862
Met Ala Ser Val Trp Gln Arg Leu Gly Phe Tyr Ala Ser Leu Leu Lys
 1               5                  10                  15      
Arg Gln Leu Asn Gly Gly Pro Asp Val Ile Lys Trp Glu Arg Arg Val
            20                  25                  30          
Ile Pro Gly Cys Thr Arg Ser Ile Tyr Ser Ala Thr Gly Lys Trp Thr
        35                  40                  45              
Lys Glu Tyr Thr Leu Gln Thr Arg Lys Asp Val Glu Lys Trp Trp His
    50                  55                  60                  
Gln Arg Ile Lys Glu Gln Ala Ser Lys Ile Ser Glu Ala Asp Lys Ser
65                  70                  75                  80  
Lys Pro Lys Phe Tyr Val Leu Ser Met Phe Pro Tyr Pro Ser Gly Lys
                85                  90                  95      
Leu His Met Gly His Val Arg Val Tyr Thr Ile Ser Asp Thr Ile Ala
            100                 105                 110         
Arg Phe Gln Lys Met Arg Gly Met Gln Val Ile Asn Pro Met Gly Trp
        115                 120                 125             
Asp Ala Phe Gly Leu Pro Ala Glu Asn Ala Ala Val Glu Arg Asn Leu
    130                 135                 140                 
His Pro Gln Ser Trp Thr Gln Ser Asn Ile Lys His Met Arg Lys Gln
145                 150                 155                 160 
Leu Asp Arg Leu Gly Leu Cys Phe Ser Trp Asp Arg Glu Ile Thr Thr
                165                 170                 175     
Cys Leu Pro Asp Tyr Tyr Lys Trp Thr Gln Tyr Leu Phe Ile Lys Leu
            180                 185                 190         
Tyr Glu Ala Gly Leu Ala Tyr Gln Lys Glu Ala Leu Val Asn Trp Asp
        195                 200                 205             
Pro Val Asp Gln Thr Val Leu Ala Asn Glu Gln Val Asp Glu His Gly
    210                 215                 220                 
Cys Ser Trp Arg Ser Gly Ala Lys Val Glu Gln Lys Tyr Leu Arg Gln
225                 230                 235                 240 
Trp Phe Ile Lys Thr Thr Ala Tyr Ala Lys Ala Met Gln Asp Ala Leu
                245                 250                 255     
Ala Asp Leu Pro Glu Trp Tyr Gly Ile Lys Gly Met Gln Ala His Trp
            260                 265                 270         
Ile Gly Asp Cys Val Gly Cys His Leu Asp Phe Thr Leu Lys Val His
        275                 280                 285             
Gly Gln Ala Thr Gly Glu Lys Leu Thr Ala Tyr Thr Ala Thr Pro Glu
    290                 295                 300                 
Ala Ile Tyr Gly Thr Ser His Val Ala Ile Ser Pro Ser His Arg Leu
305                 310                 315                 320 
Leu His Gly His Ser Ser Leu Lys Glu Ala Leu Arg Met Ala Leu Val
                325                 330                 335     
Pro Gly Lys Asp Cys Leu Thr Pro Val Met Ala Val Asn Met Leu Thr
            340                 345                 350         
Gln Gln Glu Val Pro Val Val Ile Leu Ala Lys Ala Asp Leu Glu Gly
        355                 360                 365             
Ser Leu Asp Ser Lys Ile Gly Ile Pro Ser Thr Ser Ser Glu Asp Thr
    370                 375                 380                 
Ile Leu Ala Gln Thr Leu Gly Leu Ala Tyr Ser Glu Val Ile Glu Thr
385                 390                 395                 400 
Leu Pro Asp Gly Thr Glu Arg Leu Ser Ser Ser Ala Glu Phe Thr Gly
                405                 410                 415     
Met Thr Arg Gln Asp Ala Phe Leu Ala Leu Thr Gln Lys Ala Arg Gly
            420                 425                 430         
Lys Arg Val Gly Gly Asp Val Thr Ser Asp Lys Leu Lys Asp Trp Leu
        435                 440                 445             
Ile Ser Arg Gln Arg Tyr Trp Gly Thr Pro Ile Pro Ile Val His Cys
    450                 455                 460                 
Pro Val Cys Gly Pro Thr Pro Val Pro Leu Glu Asp Leu Pro Val Thr
465                 470                 475                 480 
Leu Pro Asn Ile Ala Ser Phe Thr Gly Lys Gly Gly Pro Pro Leu Ala
                485                 490                 495     
Met Ala Ser Glu Trp Val Asn Cys Ser Cys Pro Arg Cys Lys Gly Ala
            500                 505                 510         
Ala Lys Arg Glu Thr Asp Thr Met Asp Thr Phe Val Asp Ser Ala Trp
        515                 520                 525             
Tyr Tyr Phe Arg Tyr Thr Asp Pro His Asn Pro His Ser Pro Phe Asn
    530                 535                 540                 
Thr Ala Val Ala Asp Tyr Trp Met Pro Val Asp Leu Tyr Ile Gly Gly
545                 550                 555                 560 
Lys Glu His Ala Val Met His Leu Phe Tyr Ala Arg Phe Phe Ser His
                565                 570                 575     
Phe Cys His Asp Gln Lys Met Val Lys His Arg Glu Pro Phe His Lys
            580                 585                 590         
Leu Leu Ala Gln Gly Leu Ile Lys Gly Gln Thr Phe Arg Leu Pro Ser
        595                 600                 605             
Gly Gln Tyr Leu Gln Arg Glu Glu Val Asp Leu Thr Gly Ser Val Pro
    610                 615                 620                 
Val His Ala Lys Thr Lys Glu Lys Leu Glu Val Thr Trp Glu Lys Met
625                 630                 635                 640 
Ser Lys Ser Lys His Asn Gly Val Asp Pro Glu Glu Val Val Glu Gln
                645                 650                 655     
Tyr Gly Ile Asp Thr Ile Arg Leu Tyr Ile Leu Phe Ala Ala Pro Pro
            660                 665                 670         
Glu Lys Asp Ile Leu Trp Asp Val Lys Thr Asp Ala Leu Pro Gly Val
        675                 680                 685             
Leu Arg Trp Gln Gln Arg Leu Trp Thr Leu Thr Thr Arg Phe Ile Glu
    690                 695                 700                 
Ala Arg Ala Ser Gly Lys Ser Pro Gln Pro Gln Leu Leu Ser Asn Lys
705                 710                 715                 720 
Glu Lys Ala Glu Ala Arg Lys Leu Trp Glu Tyr Lys Asn Ser Val Ile
                725                 730                 735     
Ser Gln Val Thr Thr His Phe Thr Glu Asp Phe Ser Leu Asn Ser Ala
            740                 745                 750         
Ile Ser Gln Leu Met Gly Leu Ser Asn Ala Leu Ser Gln Ala Ser Gln
        755                 760                 765             
Ser Val Ile Leu His Ser Pro Glu Phe Glu Asp Ala Leu Cys Ala Leu
    770                 775                 780                 
Met Val Met Ala Ala Pro Leu Ala Pro His Val Thr Ser Glu Ile Trp
785                 790                 795                 800 
Ala Gly Leu Ala Leu Val Pro Arg Lys Leu Cys Ala His Tyr Thr Trp
                805                 810                 815     
Asp Ala Ser Val Leu Leu Gln Ala Trp Pro Ala Val Asp Pro Glu Phe
            820                 825                 830         
Leu Gln Gln Pro Glu Val Val Gln Met Ala Val Leu Ile Asn Asn Lys
        835                 840                 845             
Ala Cys Gly Lys Ile Pro Val Pro Gln Gln Val Ala Arg Asp Gln Asp
    850                 855                 860                 
Lys Val His Glu Phe Val Leu Gln Ser Glu Leu Gly Val Arg Leu Leu
865                 870                 875                 880 
Gln Gly Arg Ser Ile Lys Lys Ser Phe Leu Ser Pro Arg Thr Ala Leu
                885                 890                 895     
Ile Asn Phe Leu Val Gln Asp
            900             


<210> 863
<211> 2209
<212> PRT
<213> Homo sapiens

<400> 863
Met Trp Asn Asp Ile Glu Leu Leu Thr Asn Asp Asp Thr Gly Ser Gly
 1               5                  10                  15      
Tyr Leu Ser Val Gly Ser Arg Lys Glu His Gly Thr Ala Leu Tyr Gln
            20                  25                  30          
Val Asp Leu Leu Val Lys Ile Ser Ser Glu Lys Ala Ser Leu Asn Pro
        35                  40                  45              
Lys Ile Gln Ala Cys Ser Leu Ser Asp Gly Phe Ile Ile Val Ala Asp
    50                  55                  60                  
Gln Ser Val Ile Leu Leu Asp Ser Ile Cys Arg Ser Leu Gln Leu His
65                  70                  75                  80  
Leu Val Phe Asp Thr Glu Val Asp Val Val Gly Leu Cys Gln Glu Gly
                85                  90                  95      
Lys Phe Leu Leu Val Gly Glu Arg Ser Gly Asn Leu His Leu Ile His
            100                 105                 110         
Val Thr Ser Lys Gln Thr Leu Leu Thr Asn Ala Phe Val Gln Lys Ala
        115                 120                 125             
Asn Asp Glu Asn Arg Arg Thr Tyr Gln Asn Leu Val Ile Glu Lys Asp
    130                 135                 140                 
Gly Ser Asn Glu Gly Thr Tyr Tyr Met Leu Leu Leu Thr Tyr Ser Gly
145                 150                 155                 160 
Phe Phe Cys Ile Thr Asn Leu Gln Leu Leu Lys Ile Gln Gln Ala Ile
                165                 170                 175     
Glu Asn Val Asp Phe Ser Thr Ala Lys Lys Leu Gln Gly Gln Ile Lys
            180                 185                 190         
Ser Ser Phe Ile Ser Thr Glu Asn Tyr His Thr Leu Gly Cys Leu Ser
        195                 200                 205             
Leu Val Ala Gly Asp Leu Ala Ser Glu Val Pro Val Ile Ile Gly Gly
    210                 215                 220                 
Thr Gly Asn Cys Ala Phe Ser Lys Trp Glu Pro Asp Ser Ser Lys Lys
225                 230                 235                 240 
Gly Met Thr Val Lys Asn Leu Ile Asp Ala Glu Ile Ile Lys Gly Ala
                245                 250                 255     
Lys Lys Phe Gln Leu Ile Asp Asn Leu Leu Phe Val Leu Asp Thr Asp
            260                 265                 270         
Asn Val Leu Ser Leu Trp Asp Ile Tyr Thr Leu Thr Pro Val Trp Asn
        275                 280                 285             
Trp Pro Ser Leu His Val Glu Glu Phe Leu Leu Thr Thr Glu Ala Asp
    290                 295                 300                 
Ser Pro Ser Ser Val Thr Trp Gln Gly Ile Thr Asn Leu Lys Leu Ile
305                 310                 315                 320 
Ala Leu Thr Ala Ser Ala Asn Lys Lys Met Lys Asn Leu Met Val Tyr
                325                 330                 335     
Ser Leu Pro Thr Met Glu Ile Leu Tyr Ser Leu Glu Val Ser Ser Val
            340                 345                 350         
Ser Ser Leu Val Gln Thr Gly Ile Ser Thr Asp Thr Ile Tyr Leu Leu
        355                 360                 365             
Glu Gly Val Cys Lys Asn Asp Pro Lys Leu Ser Glu Asp Ser Val Ser
    370                 375                 380                 
Val Leu Val Leu Arg Cys Leu Thr Glu Ala Leu Pro Glu Asn Arg Leu
385                 390                 395                 400 
Ser Arg Leu Leu His Lys His Arg Phe Ala Glu Ala Glu Ser Phe Ala
                405                 410                 415     
Ile Gln Phe Gly Leu Asp Val Glu Leu Val Tyr Lys Val Lys Ser Asn
            420                 425                 430         
His Ile Leu Glu Lys Leu Ala Leu Ser Ser Val Asp Ala Ser Glu Gln
        435                 440                 445             
Thr Glu Trp Gln Gln Leu Val Asp Asp Ala Lys Glu Asn Leu His Lys
    450                 455                 460                 
Ile Gln Asp Asp Glu Phe Val Val Asn Tyr Cys Leu Lys Ala Gln Trp
465                 470                 475                 480 
Ile Thr Tyr Glu Thr Thr Gln Glu Met Leu Asn Tyr Ala Lys Thr Arg
                485                 490                 495     
Leu Leu Lys Lys Glu Asp Lys Thr Ala Leu Ile Tyr Ser Asp Gly Leu
            500                 505                 510         
Lys Glu Val Leu Arg Ala His Ala Lys Leu Thr Thr Phe Tyr Gly Ala
        515                 520                 525             
Phe Gly Pro Glu Lys Phe Ser Gly Ser Ser Trp Ile Glu Phe Leu Asn
    530                 535                 540                 
Asn Glu Asp Asp Leu Lys Asp Ile Phe Leu Gln Leu Lys Glu Gly Asn
545                 550                 555                 560 
Leu Val Cys Ala Gln Tyr Leu Trp Leu Arg His Arg Ala Asn Phe Glu
                565                 570                 575     
Ser Arg Phe Asp Val Lys Met Leu Glu Ser Leu Leu Asn Ser Met Ser
            580                 585                 590         
Ala Ser Val Ser Leu Gln Lys Leu Cys Pro Trp Phe Lys Asn Asp Val
        595                 600                 605             
Ile Pro Phe Val Arg Arg Thr Val Pro Glu Gly Gln Ile Ile Leu Ala
    610                 615                 620                 
Lys Trp Leu Glu Gln Ala Ala Arg Asn Leu Glu Leu Thr Asp Lys Ala
625                 630                 635                 640 
Asn Trp Pro Glu Asn Gly Leu Gln Leu Ala Glu Ile Phe Phe Thr Ala
                645                 650                 655     
Glu Lys Thr Asp Glu Leu Gly Leu Ala Ser Ser Trp His Trp Ile Ser
            660                 665                 670         
Leu Lys Asp Tyr Gln Asn Thr Glu Glu Val Cys Gln Leu Arg Thr Leu
        675                 680                 685             
Val Asn Asn Leu Arg Glu Leu Ile Thr Leu His Arg Lys Tyr Asn Cys
    690                 695                 700                 
Lys Leu Ala Leu Ser Asp Phe Glu Lys Glu Asn Thr Thr Thr Ile Val
705                 710                 715                 720 
Phe Arg Met Phe Asp Lys Val Leu Ala Pro Glu Leu Ile Pro Ser Ile
                725                 730                 735     
Leu Glu Lys Phe Ile Arg Val Tyr Met Arg Glu His Asp Leu Gln Glu
            740                 745                 750         
Glu Glu Leu Leu Leu Leu Tyr Ile Glu Asp Leu Leu Asn Arg Cys Ser
        755                 760                 765             
Ser Lys Ser Thr Ser Leu Phe Glu Thr Ala Trp Glu Ala Lys Ala Met
    770                 775                 780                 
Ala Val Ile Ala Cys Leu Ser Asp Thr Asp Leu Ile Phe Asp Ala Val
785                 790                 795                 800 
Leu Lys Ile Met Tyr Ala Ala Val Val Pro Trp Ser Ala Ala Val Glu
                805                 810                 815     
Gln Leu Val Lys Gln His Leu Glu Met Asp His Pro Lys Val Lys Leu
            820                 825                 830         
Leu Gln Glu Ser Tyr Lys Leu Met Glu Met Lys Lys Leu Leu Arg Gly
        835                 840                 845             
Tyr Gly Ile Arg Glu Val Asn Leu Leu Asn Lys Glu Ile Met Arg Val
    850                 855                 860                 
Val Arg Tyr Ile Leu Lys Gln Asp Val Pro Ser Ser Leu Glu Asp Ala
865                 870                 875                 880 
Leu Lys Val Ala Gln Ala Phe Met Leu Ser Asp Asp Glu Ile Tyr Ser
                885                 890                 895     
Leu Arg Ile Ile Asp Leu Ile Asp Arg Glu Gln Gly Glu Asp Cys Leu
            900                 905                 910         
Leu Leu Leu Lys Ser Leu Pro Pro Ala Glu Ala Glu Lys Thr Ala Glu
        915                 920                 925             
Arg Val Ile Ile Trp Ala Arg Leu Ala Leu Gln Glu Glu Pro Asp His
    930                 935                 940                 
Ser Lys Glu Gly Lys Ala Trp Arg Met Ser Val Ala Lys Thr Ser Val
945                 950                 955                 960 
Asp Ile Leu Lys Ile Leu Cys Asp Ile Gln Lys Asp Asn Leu Gln Lys
                965                 970                 975     
Lys Asp Glu Cys Glu Glu Met Leu Lys Leu Phe Lys Glu Val Ala Ser
            980                 985                 990         
Leu Gln Glu Asn Phe Glu Val Phe Leu Ser Phe Glu Asp Tyr Ser Asn
        995                 1000                1005            
Ser Ser Leu Val Ala Asp Leu Arg Glu Gln His Ile Lys Ala His Glu
    1010                1015                1020                
Val Ala Gln Ala Lys His Lys Pro Gly Ser Thr Pro Glu Pro Ile Ala
1025                1030                1035                1040
Ala Glu Val Arg Ser Pro Ser Met Glu Ser Lys Leu His Arg Gln Ala
                1045                1050                1055    
Leu Ala Leu Gln Met Ser Lys Gln Glu Leu Glu Ala Glu Leu Thr Leu
            1060                1065                1070        
Arg Ala Leu Lys Asp Gly Asn Ile Lys Thr Ala Leu Lys Lys Cys Ser
        1075                1080                1085            
Asp Leu Phe Lys Tyr His Cys Asn Ala Asp Thr Gly Lys Leu Leu Phe
    1090                1095                1100                
Leu Thr Cys Gln Lys Leu Cys Gln Met Leu Ala Asp Asn Val Pro Val
1105                1110                1115                1120
Thr Val Pro Val Gly Leu Asn Leu Pro Ser Met Ile His Asp Leu Ala
                1125                1130                1135    
Ser Gln Ala Ala Thr Ile Cys Ser Pro Asp Phe Leu Leu Asp Ala Leu
            1140                1145                1150        
Glu Leu Cys Lys His Thr Leu Met Ala Val Glu Leu Ser Arg Gln Cys
        1155                1160                1165            
Gln Met Asp Asp Cys Gly Ile Leu Met Lys Ala Ser Phe Gly Thr His
    1170                1175                1180                
Lys Asp Pro Tyr Glu Glu Trp Ser Tyr Ser Asp Phe Phe Ser Glu Asp
1185                1190                1195                1200
Gly Ile Val Leu Glu Ser Gln Met Val Leu Pro Val Ile Tyr Glu Leu
                1205                1210                1215    
Ile Ser Ser Leu Val Pro Leu Ala Glu Ser Lys Arg Tyr Pro Leu Glu
            1220                1225                1230        
Ser Thr Ser Leu Pro Tyr Cys Ser Leu Asn Glu Gly Asp Gly Leu Val
        1235                1240                1245            
Leu Pro Val Ile Asn Ser Ile Ser Ala Leu Leu Gln Asn Leu Gln Glu
    1250                1255                1260                
Ser Ser Gln Trp Glu Leu Ala Leu Arg Phe Val Val Gly Ser Phe Gly
1265                1270                1275                1280
Thr Cys Leu Gln His Ser Val Ser Asn Phe Met Asn Ala Thr Leu Ser
                1285                1290                1295    
Glu Lys Leu Phe Gly Glu Thr Thr Leu Val Lys Ser Arg His Val Val
            1300                1305                1310        
Met Glu Leu Lys Glu Lys Ala Val Ile Phe Ile Arg Glu Asn Ala Thr
        1315                1320                1325            
Thr Leu Leu His Lys Val Phe Asn Cys Arg Leu Val Asp Leu Asp Leu
    1330                1335                1340                
Ala Leu Gly Tyr Cys Thr Leu Leu Pro Gln Lys Asp Val Phe Glu Asn
1345                1350                1355                1360
Leu Trp Lys Leu Ile Asp Lys Ala Trp Gln Asn Tyr Asp Lys Ile Leu
                1365                1370                1375    
Ala Ile Ser Leu Val Gly Ser Glu Leu Ala Ser Leu Tyr Gln Glu Ile
            1380                1385                1390        
Glu Met Gly Leu Lys Phe Arg Glu Leu Ser Thr Asp Ala Gln Trp Gly
        1395                1400                1405            
Ile Arg Leu Gly Lys Leu Gly Ile Ser Phe Gln Pro Val Phe Arg Gln
    1410                1415                1420                
His Phe Leu Thr Lys Lys Asp Leu Ile Lys Ala Leu Val Glu Asn Ile
1425                1430                1435                1440
Asp Met Asp Thr Ser Leu Ile Leu Glu Tyr Cys Ser Thr Phe Gln Leu
                1445                1450                1455    
Asp Cys Asp Ala Val Leu Gln Leu Phe Ile Glu Thr Leu Leu His Asn
            1460                1465                1470        
Thr Asn Ala Gly Gln Gly Gln Gly Asp Ala Ser Met Asp Ser Ala Lys
        1475                1480                1485            
Arg Arg His Pro Lys Leu Leu Ala Lys Ala Leu Glu Met Val Pro Leu
    1490                1495                1500                
Leu Thr Ser Thr Lys Asp Leu Val Ile Ser Leu Ser Gly Ile Leu His
1505                1510                1515                1520
Lys Leu Asp Pro Tyr Asp Tyr Glu Met Ile Glu Val Val Leu Lys Val
                1525                1530                1535    
Ile Glu Arg Ala Asp Glu Lys Ile Thr Asn Ile Asn Ile Asn Gln Ala
            1540                1545                1550        
Leu Ser Ile Leu Lys His Leu Lys Ser Tyr Arg Arg Ile Ser Pro Pro
        1555                1560                1565            
Val Asp Leu Glu Tyr Gln Tyr Met Leu Glu His Val Ile Thr Leu Pro
    1570                1575                1580                
Ser Ala Ala Gln Thr Arg Leu Pro Phe His Leu Ile Phe Phe Gly Thr
1585                1590                1595                1600
Ala Gln Asn Phe Trp Lys Ile Leu Ser Thr Glu Leu Ser Glu Glu Ser
                1605                1610                1615    
Phe Pro Thr Leu Leu Leu Ile Ser Lys Leu Met Lys Phe Ser Leu Asp
            1620                1625                1630        
Thr Leu Tyr Val Ser Thr Ala Lys His Val Phe Glu Lys Lys Leu Lys
        1635                1640                1645            
Pro Lys Leu Leu Lys Leu Thr Gln Ala Lys Ser Ser Thr Leu Ile Asn
    1650                1655                1660                
Lys Glu Ile Thr Lys Ile Thr Gln Thr Ile Glu Ser Cys Leu Leu Ser
1665                1670                1675                1680
Ile Val Asn Pro Glu Trp Ala Val Ala Ile Ala Ile Ser Leu Ala Gln
                1685                1690                1695    
Asp Ile Pro Glu Gly Ser Phe Lys Ile Ser Ala Leu Lys Phe Cys Leu
            1700                1705                1710        
Tyr Leu Ala Glu Arg Trp Leu Gln Asn Ile Pro Ser Gln Asp Glu Lys
        1715                1720                1725            
Arg Glu Lys Ala Glu Ala Leu Leu Lys Lys Leu His Ile Gln Tyr Arg
    1730                1735                1740                
Arg Ser Gly Thr Glu Ala Val Leu Ile Ala His Lys Leu Asn Thr Glu
1745                1750                1755                1760
Glu Tyr Leu Arg Val Ile Gly Lys Pro Ala His Leu Ile Val Ser Leu
                1765                1770                1775    
Tyr Glu His Pro Ser Ile Asn Gln Arg Ile Gln Asn Ser Ser Gly Thr
            1780                1785                1790        
Asp Tyr Pro Asp Ile His Ala Ala Ala Lys Glu Ile Ala Glu Val Asn
        1795                1800                1805            
Glu Ile Asn Leu Glu Lys Val Trp Asp Met Leu Leu Glu Lys Trp Leu
    1810                1815                1820                
Cys Pro Ser Thr Lys Pro Gly Glu Lys Pro Ser Glu Leu Phe Glu Leu
1825                1830                1835                1840
Gln Glu Asp Glu Ala Leu Arg Arg Val Gln Tyr Leu Leu Leu Ser Arg
                1845                1850                1855    
Pro Ile Asp Tyr Ser Ser Arg Met Leu Phe Val Phe Ala Thr Ser Thr
            1860                1865                1870        
Thr Thr Thr Leu Gly Met His Gln Leu Thr Phe Ala His Arg Thr Arg
        1875                1880                1885            
Ala Leu Gln Cys Leu Phe Tyr Leu Ala Asp Lys Glu Thr Ile Glu Ser
    1890                1895                1900                
Leu Phe Lys Lys Pro Ile Glu Glu Val Lys Ser Tyr Leu Arg Cys Ile
1905                1910                1915                1920
Thr Phe Leu Ala Ser Phe Glu Thr Leu Asn Ile Pro Ile Thr Tyr Glu
                1925                1930                1935    
Leu Phe Cys Ser Ser Pro Lys Glu Gly Met Ile Lys Gly Leu Trp Lys
            1940                1945                1950        
Asn His Ser His Glu Ser Met Ala Val Arg Leu Val Thr Glu Leu Cys
        1955                1960                1965            
Leu Glu Tyr Lys Ile Tyr Asp Leu Gln Leu Trp Asn Gly Leu Leu Gln
    1970                1975                1980                
Lys Leu Leu Gly Phe Asn Met Ile Pro Tyr Leu Arg Lys Val Leu Lys
1985                1990                1995                2000
Ala Ile Ser Ser Ile His Ser Leu Trp Gln Val Pro Tyr Phe Ser Lys
                2005                2010                2015    
Ala Trp Gln Arg Val Ile Gln Ile Pro Leu Leu Ser Ala Ser Cys Pro
            2020                2025                2030        
Leu Ser Pro Asp Gln Leu Ser Asp Cys Ser Glu Ser Leu Ile Ala Val
        2035                2040                2045            
Leu Glu Cys Pro Val Ser Gly Asp Leu Asp Leu Ile Gly Val Ala Arg
    2050                2055                2060                
Gln Tyr Ile Gln Leu Glu Leu Pro Ala Phe Ala Leu Ala Cys Leu Met
2065                2070                2075                2080
Leu Met Pro His Ser Glu Lys Arg His Gln Gln Ile Lys Asn Phe Leu
                2085                2090                2095    
Gly Ser Cys Asp Pro Gln Val Ile Leu Lys Gln Leu Glu Glu His Met
            2100                2105                2110        
Asn Thr Gly Gln Leu Ala Gly Phe Ser His Gln Ile Arg Ser Leu Ile
        2115                2120                2125            
Leu Asn Asn Ile Ile Asn Lys Lys Glu Phe Gly Ile Leu Ala Lys Thr
    2130                2135                2140                
Lys Tyr Phe Gln Met Leu Lys Met His Ala Met Asn Thr Asn Asn Ile
2145                2150                2155                2160
Thr Glu Leu Val Asn Tyr Leu Ala Asn Asp Leu Ser Leu Asp Glu Ala
                2165                2170                2175    
Ser Val Leu Ile Thr Glu Tyr Ser Lys His Cys Gly Lys Pro Val Pro
            2180                2185                2190        
Pro Asp Thr Ala Pro Cys Glu Ile Leu Lys Met Phe Leu Ser Gly Leu
        2195                2200                2205            
Ser
    


<210> 864
<211> 370
<212> PRT
<213> Homo sapiens

<400> 864
Met Ala Ile Thr Leu Glu Glu Ala Pro Trp Leu Gly Trp Leu Leu Val
 1               5                  10                  15      
Lys Ala Leu Met Arg Phe Ala Phe Met Val Val Asn Asn Leu Val Ala
            20                  25                  30          
Ile Pro Ser Tyr Ile Cys Tyr Val Ile Ile Leu Gln Pro Leu Arg Val
        35                  40                  45              
Leu Asp Ser Lys Arg Phe Trp Tyr Ile Glu Gly Ile Met Tyr Lys Trp
    50                  55                  60                  
Leu Leu Gly Met Val Ala Ser Trp Gly Trp Tyr Ala Gly Tyr Thr Val
65                  70                  75                  80  
Met Glu Trp Gly Glu Asp Ile Lys Ala Val Ser Lys Asp Glu Ala Val
                85                  90                  95      
Met Leu Val Asn His Gln Ala Thr Gly Asp Val Cys Thr Leu Met Met
            100                 105                 110         
Cys Leu Gln Asp Lys Gly Leu Val Val Ala Gln Met Met Trp Leu Met
        115                 120                 125             
Asp His Ile Phe Lys Tyr Thr Asn Phe Gly Ile Val Ser Leu Val His
    130                 135                 140                 
Gly Asp Phe Phe Ile Arg Gln Gly Arg Ser Tyr Arg Asp Gln Gln Leu
145                 150                 155                 160 
Leu Leu Leu Lys Lys His Leu Glu Asn Asn Tyr Arg Ser Arg Asp Arg
                165                 170                 175     
Lys Trp Ile Val Leu Phe Pro Glu Gly Gly Phe Leu Arg Lys Arg Arg
            180                 185                 190         
Glu Thr Ser Gln Ala Phe Ala Lys Lys Asn Asn Leu Pro Phe Leu Thr
        195                 200                 205             
Asn Val Thr Leu Pro Arg Ser Gly Ala Thr Lys Ile Ile Leu Asn Ala
    210                 215                 220                 
Leu Val Ala Gln Gln Lys Asn Gly Ser Pro Ala Gly Gly Asp Ala Lys
225                 230                 235                 240 
Glu Leu Asp Ser Lys Ser Lys Gly Leu Gln Trp Ile Ile Asp Thr Thr
                245                 250                 255     
Ile Ala Tyr Pro Lys Ala Glu Pro Ile Asp Ile Gln Thr Trp Ile Leu
            260                 265                 270         
Gly Tyr Arg Lys Pro Thr Val Thr His Val His Tyr Arg Ile Phe Pro
        275                 280                 285             
Ile Lys Asp Val Pro Leu Glu Thr Asp Asp Leu Thr Thr Trp Leu Tyr
    290                 295                 300                 
Gln Arg Phe Val Glu Lys Glu Asp Leu Leu Ser His Phe Tyr Glu Thr
305                 310                 315                 320 
Gly Ala Phe Pro Pro Ser Lys Gly His Lys Glu Ala Val Ser Arg Glu
                325                 330                 335     
Met Thr Leu Ser Asn Leu Trp Ile Phe Leu Ile Gln Ser Phe Ala Phe
            340                 345                 350         
Leu Ser Gly Tyr Met Trp Tyr Asn Ile Ile Gln Tyr Phe Tyr His Cys
        355                 360                 365             
Leu Phe
    370 


<210> 865
<211> 1121
<212> PRT
<213> Homo sapiens

<400> 865
Met His Ser Asp Glu Met Ile Tyr Asp Asp Val Glu Asn Gly Asp Glu
 1               5                  10                  15      
Gly Gly Asn Ser Ser Leu Glu Tyr Gly Trp Ser Ser Ser Glu Phe Glu
            20                  25                  30          
Ser Tyr Glu Glu Gln Ser Asp Ser Glu Cys Lys Asn Gly Ile Pro Arg
        35                  40                  45              
Ser Phe Leu Arg Ser Asn His Lys Lys Gln Leu Ser His Asp Leu Thr
    50                  55                  60                  
Arg Leu Lys Glu His Tyr Glu Lys Lys Met Arg Asp Leu Met Ala Ser
65                  70                  75                  80  
Thr Val Gly Val Val Glu Ile Gln Gln Leu Arg Gln Lys His Glu Leu
                85                  90                  95      
Lys Met Gln Lys Leu Val Lys Ala Ala Lys Asp Gly Thr Lys Asp Gly
            100                 105                 110         
Leu Glu Arg Thr Arg Ala Ala Val Lys Arg Gly Arg Ser Phe Ile Arg
        115                 120                 125             
Thr Lys Ser Leu Ile Ala Gln Asp His Arg Ser Ser Leu Glu Glu Glu
    130                 135                 140                 
Gln Asn Leu Phe Ile Asp Val Asp Cys Lys His Pro Glu Ala Ile Leu
145                 150                 155                 160 
Thr Pro Met Pro Glu Gly Leu Ser Gln Gln Gln Val Val Arg Arg Tyr
                165                 170                 175     
Ile Leu Gly Ser Val Val Asp Ser Glu Lys Asn Tyr Val Asp Ala Leu
            180                 185                 190         
Lys Arg Ile Leu Glu Gln Tyr Glu Lys Pro Leu Ser Glu Met Glu Pro
        195                 200                 205             
Lys Val Leu Ser Glu Arg Lys Leu Lys Thr Val Phe Tyr Arg Val Lys
    210                 215                 220                 
Glu Ile Leu Gln Cys His Ser Leu Phe Gln Ile Ala Leu Ala Ser Arg
225                 230                 235                 240 
Val Ser Glu Trp Asp Ser Val Glu Met Ile Gly Asp Val Phe Val Ala
                245                 250                 255     
Ser Phe Ser Lys Ser Met Val Leu Asp Ala Tyr Ser Glu Tyr Val Asn
            260                 265                 270         
Asn Phe Ser Thr Ala Val Ala Val Leu Lys Lys Thr Cys Ala Thr Lys
        275                 280                 285             
Pro Ala Phe Leu Glu Phe Leu Lys Gln Glu Gln Glu Ala Ser Pro Asp
    290                 295                 300                 
Arg Thr Thr Leu Tyr Ser Leu Met Met Lys Pro Ile Gln Arg Phe Pro
305                 310                 315                 320 
Gln Phe Ile Leu Leu Leu Gln Asp Met Leu Lys Asn Thr Ser Lys Gly
                325                 330                 335     
His Pro Asp Arg Leu Pro Leu Gln Met Ala Leu Thr Glu Leu Glu Thr
            340                 345                 350         
Leu Ala Glu Lys Leu Asn Glu Arg Lys Arg Asp Ala Asp Gln Arg Cys
        355                 360                 365             
Glu Val Lys Gln Ile Ala Lys Ala Ile Asn Glu Arg Tyr Leu Asn Lys
    370                 375                 380                 
Leu Leu Ser Ser Gly Ser Arg Tyr Leu Ile Arg Ser Asp Asp Met Ile
385                 390                 395                 400 
Glu Thr Val Tyr Asn Asp Arg Gly Glu Ile Val Lys Thr Lys Glu Arg
                405                 410                 415     
Arg Val Phe Met Leu Asn Asp Val Leu Met Cys Ala Thr Val Ser Ser
            420                 425                 430         
Arg Pro Ser His Asp Ser Arg Val Met Ser Ser Gln Arg Tyr Leu Leu
        435                 440                 445             
Lys Trp Ser Val Pro Leu Gly His Val Asp Ala Ile Glu Tyr Gly Ser
    450                 455                 460                 
Ser Ala Gly Thr Gly Glu His Ser Arg His Leu Ala Val His Pro Pro
465                 470                 475                 480 
Glu Ser Leu Ala Val Val Ala Asn Ala Lys Pro Asn Lys Val Tyr Met
                485                 490                 495     
Gly Pro Gly Gln Leu Tyr Gln Asp Leu Gln Asn Leu Leu His Asp Leu
            500                 505                 510         
Asn Val Ile Gly Gln Ile Thr Gln Leu Ile Gly Asn Leu Lys Gly Asn
        515                 520                 525             
Tyr Gln Asn Leu Asn Gln Ser Val Ala His Asp Trp Thr Ser Gly Leu
    530                 535                 540                 
Gln Arg Leu Ile Leu Lys Lys Glu Asp Glu Ile Arg Ala Ala Asp Cys
545                 550                 555                 560 
Cys Arg Ile Gln Leu Gln Leu Pro Gly Lys Gln Asp Lys Ser Gly Arg
                565                 570                 575     
Pro Thr Phe Phe Thr Ala Val Phe Asn Thr Phe Thr Pro Ala Ile Lys
            580                 585                 590         
Glu Ser Trp Val Asn Ser Leu Gln Met Ala Lys Leu Ala Leu Glu Glu
        595                 600                 605             
Glu Asn His Met Gly Trp Phe Cys Val Glu Asp Asp Gly Asn His Ile
    610                 615                 620                 
Lys Lys Glu Lys His Pro Leu Leu Val Gly His Met Pro Val Met Val
625                 630                 635                 640 
Ala Lys Gln Gln Glu Phe Lys Ile Glu Cys Ala Ala Tyr Asn Pro Glu
                645                 650                 655     
Pro Tyr Leu Asn Asn Glu Ser Gln Pro Asp Ser Phe Ser Thr Ala His
            660                 665                 670         
Gly Phe Leu Trp Ile Gly Ser Cys Thr His Gln Met Gly Gln Ile Ala
        675                 680                 685             
Ile Val Ser Phe Gln Asn Ser Thr Pro Lys Val Ile Glu Cys Phe Asn
    690                 695                 700                 
Val Glu Ser Arg Ile Leu Cys Met Leu Tyr Val Pro Val Glu Glu Lys
705                 710                 715                 720 
Arg Arg Glu Pro Gly Ala Pro Pro Asp Pro Glu Thr Pro Ala Val Arg
                725                 730                 735     
Ala Ser Asp Val Pro Thr Ile Cys Val Gly Thr Glu Glu Gly Ser Ile
            740                 745                 750         
Ser Ile Tyr Lys Ser Ser Gln Gly Ser Lys Lys Val Arg Leu Gln His
        755                 760                 765             
Phe Phe Thr Pro Glu Lys Ser Thr Val Met Ser Leu Ala Cys Thr Ser
    770                 775                 780                 
Gln Ser Leu Tyr Ala Gly Leu Val Asn Gly Ala Val Ala Ser Tyr Ala
785                 790                 795                 800 
Arg Ala Pro Asp Gly Ser Trp Asp Ser Glu Pro Gln Lys Val Ile Lys
                805                 810                 815     
Leu Gly Val Leu Pro Val Arg Ser Leu Leu Met Met Glu Asp Thr Leu
            820                 825                 830         
Trp Ala Ala Ser Gly Gly Gln Val Phe Ile Ile Ser Val Glu Thr His
        835                 840                 845             
Ala Val Glu Gly Gln Leu Glu Ala His Gln Glu Glu Gly Met Val Ile
    850                 855                 860                 
Ser His Met Ala Val Ser Gly Val Gly Ile Trp Ile Ala Phe Thr Ser
865                 870                 875                 880 
Gly Ser Thr Leu Arg Leu Phe His Thr Glu Thr Leu Lys His Leu Gln
                885                 890                 895     
Asp Ile Asn Ile Ala Thr Pro Val His Asn Met Leu Pro Gly His Gln
            900                 905                 910         
Arg Leu Ser Val Thr Ser Leu Leu Val Cys His Gly Leu Leu Met Val
        915                 920                 925             
Gly Thr Ser Leu Gly Val Leu Val Ala Leu Pro Val Pro Arg Leu Gln
    930                 935                 940                 
Gly Ile Pro Lys Val Thr Gly Arg Gly Met Val Ser Tyr His Ala His
945                 950                 955                 960 
Asn Ser Pro Val Lys Phe Ile Val Leu Ala Thr Ala Leu His Glu Lys
                965                 970                 975     
Asp Lys Asp Lys Ser Arg Asp Ser Leu Ala Pro Gly Pro Glu Pro Gln
            980                 985                 990         
Asp Glu Asp Gln Lys Asp Ala Leu Pro Ser Gly Gly Ala Gly Ser Ser
        995                 1000                1005            
Leu Ser Gln Gly Asp Pro Asp Ala Ala Ile Trp Leu Gly Asp Ser Leu
    1010                1015                1020                
Gly Ser Met Thr Gln Lys Ser Asp Leu Ser Ser Ser Ser Gly Ser Leu
1025                1030                1035                1040
Ser Leu Ser His Gly Ser Ser Ser Leu Glu His Arg Ser Glu Asp Ser
                1045                1050                1055    
Thr Ile Tyr Asp Leu Leu Lys Asp Pro Val Ser Leu Arg Ser Lys Ala
            1060                1065                1070        
Arg Arg Ala Lys Lys Ala Lys Ala Ser Ser Ala Leu Val Val Cys Gly
        1075                1080                1085            
Gly Gln Gly His Arg Arg Val His Arg Lys Ala Arg Gln Pro His Gln
    1090                1095                1100                
Glu Glu Leu Ala Pro Thr Val Met Val Trp Gln Ile Pro Leu Leu Asn
1105                1110                1115                1120
Ile
    


<210> 866
<211> 2715
<212> PRT
<213> Homo sapiens

<400> 866
Met Ala Ala Ala Ala Gly Gly Gly Ser Cys Pro Gly Pro Gly Ser Ala
 1               5                  10                  15      
Arg Gly Arg Phe Pro Gly Arg Pro Arg Gly Ala Gly Gly Gly Gly Gly
            20                  25                  30          
Arg Gly Gly Arg Gly Asn Gly Ala Glu Arg Val Arg Val Ala Leu Arg
        35                  40                  45              
Arg Gly Gly Gly Ala Thr Gly Pro Gly Gly Ala Glu Pro Gly Glu Asp
    50                  55                  60                  
Thr Ala Leu Leu Arg Leu Leu Gly Leu Arg Arg Gly Leu Arg Arg Leu
65                  70                  75                  80  
Arg Arg Leu Trp Ala Gly Pro Arg Val Gln Arg Gly Arg Gly Arg Gly
                85                  90                  95      
Arg Gly Arg Gly Trp Gly Pro Ser Arg Gly Cys Val Pro Glu Glu Glu
            100                 105                 110         
Ser Ser Asp Gly Glu Ser Asp Glu Glu Glu Phe Gln Gly Phe His Ser
        115                 120                 125             
Asp Glu Asp Val Ala Pro Ser Ser Leu Arg Ser Ala Leu Arg Ser Gln
    130                 135                 140                 
Arg Gly Arg Ala Pro Arg Gly Arg Gly Arg Lys His Lys Thr Thr Pro
145                 150                 155                 160 
Leu Pro Pro Pro Arg Leu Ala Asp Val Ala Pro Thr Pro Pro Lys Thr
                165                 170                 175     
Pro Ala Arg Lys Arg Gly Glu Glu Gly Thr Glu Arg Met Val Gln Ala
            180                 185                 190         
Leu Thr Glu Leu Leu Arg Arg Ala Gln Ala Pro Gln Ala Pro Arg Ser
        195                 200                 205             
Arg Ala Cys Glu Pro Ser Thr Pro Arg Arg Ser Arg Gly Arg Pro Pro
    210                 215                 220                 
Gly Arg Pro Ala Gly Pro Cys Arg Arg Lys Gln Gln Ala Val Val Val
225                 230                 235                 240 
Ala Glu Ala Ala Val Thr Ile Pro Lys Pro Glu Pro Pro Pro Pro Val
                245                 250                 255     
Val Pro Val Lys His Gln Thr Gly Ser Trp Lys Cys Lys Glu Gly Pro
            260                 265                 270         
Gly Pro Gly Pro Gly Thr Pro Arg Arg Gly Gly Gln Ser Ser Arg Gly
        275                 280                 285             
Gly Arg Gly Gly Arg Gly Arg Gly Arg Gly Gly Gly Leu Pro Phe Val
    290                 295                 300                 
Ile Lys Phe Val Ser Arg Ala Lys Lys Val Lys Met Gly Gln Leu Ser
305                 310                 315                 320 
Leu Gly Leu Glu Ser Gly Gln Gly Gln Gly Gln His Glu Glu Ser Trp
                325                 330                 335     
Gln Asp Val Pro Gln Arg Arg Val Gly Ser Gly Gln Gly Gly Ser Pro
            340                 345                 350         
Cys Trp Lys Lys Gln Glu Gln Lys Leu Asp Asp Glu Glu Glu Glu Lys
        355                 360                 365             
Lys Glu Glu Glu Glu Lys Asp Lys Glu Gly Glu Glu Lys Glu Glu Arg
    370                 375                 380                 
Ala Val Ala Glu Glu Met Met Pro Ala Ala Glu Lys Glu Glu Ala Lys
385                 390                 395                 400 
Leu Pro Pro Pro Pro Leu Thr Pro Pro Ala Pro Ser Pro Pro Pro Pro
                405                 410                 415     
Leu Pro Pro Pro Ser Thr Ser Pro Pro Pro Pro Leu Cys Pro Pro Pro
            420                 425                 430         
Pro Pro Pro Val Ser Pro Pro Pro Leu Pro Ser Pro Pro Pro Pro Pro
        435                 440                 445             
Ala Gln Glu Glu Gln Glu Glu Ser Pro Pro Pro Val Val Pro Ala Thr
    450                 455                 460                 
Cys Ser Arg Lys Arg Gly Arg Pro Pro Leu Thr Pro Ser Gln Arg Ala
465                 470                 475                 480 
Glu Arg Glu Ala Ala Arg Ala Gly Pro Glu Gly Thr Ser Pro Pro Thr
                485                 490                 495     
Pro Thr Pro Ser Thr Ala Thr Gly Gly Pro Pro Glu Asp Ser Pro Thr
            500                 505                 510         
Val Ala Pro Lys Ser Thr Thr Phe Leu Lys Asn Ile Arg Gln Phe Ile
        515                 520                 525             
Met Pro Val Val Ser Ala Arg Ser Ser Arg Val Ile Lys Thr Pro Arg
    530                 535                 540                 
Arg Phe Met Asp Glu Asp Pro Pro Lys Pro Pro Lys Val Glu Val Ser
545                 550                 555                 560 
Pro Val Leu Arg Pro Pro Ile Thr Thr Ser Pro Pro Val Pro Gln Glu
                565                 570                 575     
Pro Ala Pro Val Pro Ser Pro Pro Arg Ala Pro Thr Pro Pro Ser Thr
            580                 585                 590         
Pro Val Pro Leu Pro Glu Lys Arg Arg Ser Ile Leu Arg Glu Pro Thr
        595                 600                 605             
Phe Arg Trp Thr Ser Leu Thr Arg Glu Leu Pro Pro Pro Pro Pro Ala
    610                 615                 620                 
Pro Pro Pro Pro Pro Ala Pro Ser Pro Pro Pro Ala Pro Ala Thr Ser
625                 630                 635                 640 
Ser Arg Arg Pro Leu Leu Leu Arg Ala Pro Gln Phe Thr Pro Ser Glu
                645                 650                 655     
Ala His Leu Lys Ile Tyr Glu Ser Val Leu Thr Pro Pro Pro Leu Gly
            660                 665                 670         
Ala Pro Glu Ala Pro Glu Pro Glu Pro Pro Pro Ala Asp Asp Ser Pro
        675                 680                 685             
Ala Glu Pro Glu Pro Arg Ala Val Gly Arg Thr Asn His Leu Ser Leu
    690                 695                 700                 
Pro Arg Phe Ala Pro Val Val Thr Thr Pro Val Lys Ala Glu Val Ser
705                 710                 715                 720 
Pro His Gly Ala Pro Ala Leu Ser Asn Gly Pro Gln Thr Gln Ala Gln
                725                 730                 735     
Leu Leu Gln Pro Leu Gln Ala Leu Gln Thr Gln Leu Leu Pro Gln Ala
            740                 745                 750         
Leu Pro Pro Pro Gln Pro Gln Leu Gln Pro Pro Pro Ser Pro Gln Gln
        755                 760                 765             
Met Pro Pro Leu Glu Lys Ala Arg Ile Ala Gly Val Gly Ser Leu Pro
    770                 775                 780                 
Leu Ser Gly Val Glu Glu Lys Met Phe Ser Leu Leu Lys Arg Ala Lys
785                 790                 795                 800 
Val Gln Leu Phe Lys Ile Asp Gln Gln Gln Gln Gln Lys Val Ala Ala
                805                 810                 815     
Ser Met Pro Leu Ser Pro Gly Gly Gln Met Glu Glu Val Ala Gly Ala
            820                 825                 830         
Val Lys Gln Ile Ser Asp Arg Gly Pro Val Arg Ser Glu Asp Glu Ser
        835                 840                 845             
Val Glu Ala Lys Arg Glu Arg Pro Ser Gly Pro Glu Ser Pro Val Gln
    850                 855                 860                 
Gly Pro Arg Ile Lys His Val Cys Arg His Ala Ala Val Ala Leu Gly
865                 870                 875                 880 
Gln Ala Arg Ala Met Val Pro Glu Asp Val Pro Arg Leu Ser Ala Leu
                885                 890                 895     
Pro Leu Arg Asp Arg Gln Asp Leu Ala Thr Glu Asp Thr Ser Ser Ala
            900                 905                 910         
Ser Glu Thr Glu Ser Val Pro Ser Arg Ser Arg Arg Gly Lys Val Glu
        915                 920                 925             
Ala Ala Gly Pro Gly Gly Glu Ser Glu Pro Thr Gly Ser Gly Gly Thr
    930                 935                 940                 
Leu Ala His Thr Pro Arg Arg Ser Leu Pro Ser His His Gly Lys Lys
945                 950                 955                 960 
Met Arg Met Ala Arg Cys Gly His Cys Arg Gly Cys Leu Arg Val Gln
                965                 970                 975     
Asp Cys Gly Ser Cys Val Asn Cys Leu Asp Lys Pro Lys Phe Gly Gly
            980                 985                 990         
Pro Asn Thr Lys Lys Gln Cys Cys Val Tyr Arg Lys Cys Asp Lys Ile
        995                 1000                1005            
Glu Ala Arg Lys Met Glu Arg Leu Ala Lys Lys Gly Arg Thr Ile Val
    1010                1015                1020                
Lys Thr Leu Leu Pro Trp Asp Ser Asp Glu Ser Pro Glu Ala Ser Pro
1025                1030                1035                1040
Gly Pro Pro Gly Pro Arg Arg Gly Ala Gly Ala Gly Gly Pro Arg Glu
                1045                1050                1055    
Glu Val Val Ala His Pro Gly Pro Glu Glu Gln Asp Ser Leu Leu Gln
            1060                1065                1070        
Arg Lys Ser Ala Arg Arg Cys Val Lys Gln Arg Pro Ser Tyr Asp Ile
        1075                1080                1085            
Phe Glu Asp Ser Asp Asp Ser Glu Pro Gly Gly Pro Pro Ala Pro Arg
    1090                1095                1100                
Arg Arg Thr Pro Arg Glu Asn Glu Leu Pro Leu Pro Glu Pro Glu Glu
1105                1110                1115                1120
Gln Ser Arg Pro Arg Lys Pro Thr Leu Gln Pro Val Leu Gln Leu Lys
                1125                1130                1135    
Ala Arg Arg Arg Leu Asp Lys Asp Ala Leu Ala Pro Gly Pro Phe Ala
            1140                1145                1150        
Ser Phe Pro Asn Gly Trp Thr Gly Lys Gln Lys Ser Pro Asp Gly Val
        1155                1160                1165            
His Arg Val Arg Val Asp Phe Lys Glu Asp Cys Asp Leu Glu Asn Val
    1170                1175                1180                
Trp Leu Met Gly Gly Leu Ser Val Leu Thr Ser Val Pro Gly Gly Pro
1185                1190                1195                1200
Pro Met Val Cys Leu Leu Cys Ala Ser Lys Gly Leu His Glu Leu Val
                1205                1210                1215    
Phe Cys Gln Val Cys Cys Asp Pro Phe His Pro Phe Cys Leu Glu Glu
            1220                1225                1230        
Ala Glu Arg Pro Leu Pro Gln His His Asp Thr Trp Cys Cys Arg Arg
        1235                1240                1245            
Cys Lys Phe Cys His Val Cys Gly Arg Lys Gly Arg Gly Ser Lys His
    1250                1255                1260                
Leu Leu Glu Cys Glu Arg Cys Arg His Ala Tyr His Pro Ala Cys Leu
1265                1270                1275                1280
Gly Pro Ser Tyr Pro Thr Arg Ala Thr Arg Lys Arg Arg His Trp Ile
                1285                1290                1295    
Cys Ser Ala Cys Val Arg Cys Lys Ser Cys Gly Ala Thr Pro Gly Lys
            1300                1305                1310        
Asn Trp Asp Val Glu Trp Ser Gly Asp Tyr Ser Leu Cys Pro Arg Cys
        1315                1320                1325            
Thr Gln Leu Tyr Glu Lys Gly Asn Tyr Cys Pro Ile Cys Thr Arg Cys
    1330                1335                1340                
Tyr Glu Asp Asn Asp Tyr Glu Ser Lys Met Met Gln Cys Ala Gln Cys
1345                1350                1355                1360
Asp His Trp Val His Ala Lys Cys Glu Gly Leu Ser Asp Glu Asp Tyr
                1365                1370                1375    
Glu Ile Leu Ser Gly Leu Pro Asp Ser Val Leu Tyr Thr Cys Gly Pro
            1380                1385                1390        
Cys Ala Gly Ala Ala Gln Pro Arg Trp Arg Glu Ala Leu Ser Gly Ala
        1395                1400                1405            
Leu Gln Gly Gly Leu Arg Gln Val Leu Gln Gly Leu Leu Ser Ser Lys
    1410                1415                1420                
Val Val Gly Pro Leu Leu Leu Cys Thr Gln Cys Gly Pro Asp Gly Lys
1425                1430                1435                1440
Gln Leu His Pro Gly Pro Cys Gly Leu Gln Ala Val Ser Gln Arg Phe
                1445                1450                1455    
Glu Asp Gly His Tyr Lys Ser Val His Ser Phe Met Glu Asp Met Val
            1460                1465                1470        
Gly Ile Leu Met Arg His Ser Glu Glu Gly Glu Thr Pro Asp Arg Arg
        1475                1480                1485            
Ala Gly Gly Gln Met Lys Gly Leu Leu Leu Lys Leu Leu Glu Ser Ala
    1490                1495                1500                
Phe Gly Trp Phe Asp Ala His Asp Pro Lys Tyr Trp Arg Arg Ser Thr
1505                1510                1515                1520
Arg Leu Pro Asn Gly Val Leu Pro Asn Ala Val Leu Pro Pro Ser Leu
                1525                1530                1535    
Asp His Val Tyr Ala Gln Trp Arg Gln Gln Glu Pro Glu Thr Pro Glu
            1540                1545                1550        
Ser Gly Gln Pro Pro Gly Asp Pro Ser Ala Ala Phe Gln Gly Lys Asp
        1555                1560                1565            
Pro Ala Ala Phe Ser His Leu Glu Asp Pro Arg Gln Cys Ala Leu Cys
    1570                1575                1580                
Leu Lys Tyr Gly Asp Ala Asp Ser Lys Glu Ala Gly Arg Leu Leu Tyr
1585                1590                1595                1600
Ile Gly Gln Asn Glu Trp Thr His Val Asn Cys Ala Ile Trp Ser Ala
                1605                1610                1615    
Glu Val Phe Glu Glu Asn Asp Gly Ser Leu Lys Asn Val His Ala Ala
            1620                1625                1630        
Val Ala Arg Gly Arg Gln Met Arg Cys Glu Leu Cys Leu Lys Pro Gly
        1635                1640                1645            
Ala Thr Val Gly Cys Cys Leu Ser Ser Cys Leu Ser Asn Phe His Phe
    1650                1655                1660                
Met Cys Ala Arg Ala Ser Tyr Cys Ile Phe Gln Asp Asp Lys Lys Val
1665                1670                1675                1680
Phe Cys Gln Lys His Thr Asp Leu Leu Asp Gly Lys Glu Ile Val Asn
                1685                1690                1695    
Pro Asp Gly Phe Asp Val Leu Arg Arg Val Tyr Val Asp Phe Glu Gly
            1700                1705                1710        
Ile Asn Phe Lys Arg Lys Phe Leu Thr Gly Leu Glu Pro Asp Ala Ile
        1715                1720                1725            
Asn Val Leu Ile Gly Ser Ile Arg Ile Asp Ser Leu Gly Thr Leu Ser
    1730                1735                1740                
Asp Leu Ser Asp Cys Glu Gly Arg Leu Phe Pro Ile Gly Tyr Gln Cys
1745                1750                1755                1760
Ser Arg Leu Tyr Trp Ser Thr Val Asp Ala Arg Arg Arg Cys Trp Tyr
                1765                1770                1775    
Arg Cys Arg Ile Leu Glu Tyr Arg Pro Trp Gly Pro Arg Glu Glu Pro
            1780                1785                1790        
Ala His Leu Glu Ala Ala Glu Glu Asn Gln Thr Ile Val His Ser Pro
        1795                1800                1805            
Ala Pro Ser Ser Glu Pro Pro Gly Gly Glu Asp Pro Pro Leu Asp Thr
    1810                1815                1820                
Asp Val Leu Val Pro Gly Ala Pro Glu Arg His Ser Pro Ile Gln Asn
1825                1830                1835                1840
Leu Asp Pro Pro Leu Arg Pro Asp Ser Gly Ser Ala Pro Pro Pro Ala
                1845                1850                1855    
Pro Arg Ser Phe Ser Gly Ala Arg Ile Lys Val Pro Asn Tyr Ser Pro
            1860                1865                1870        
Ser Arg Arg Pro Leu Gly Gly Val Ser Phe Gly Pro Leu Pro Ser Pro
        1875                1880                1885            
Gly Ser Pro Ser Ser Leu Thr His His Ile Pro Thr Val Gly Asp Pro
    1890                1895                1900                
Asp Phe Pro Ala Pro Pro Arg Arg Ser Arg Arg Pro Ser Pro Leu Ala
1905                1910                1915                1920
Pro Arg Pro Pro Pro Ser Arg Trp Ala Ser Pro Pro Leu Lys Thr Ser
                1925                1930                1935    
Pro Gln Leu Arg Val Pro Pro Pro Thr Ser Val Val Thr Ala Leu Thr
            1940                1945                1950        
Pro Thr Ser Gly Glu Leu Ala Pro Pro Gly Pro Ala Pro Ser Pro Pro
        1955                1960                1965            
Pro Pro Glu Asp Leu Gly Pro Asp Phe Glu Asp Met Glu Val Val Ser
    1970                1975                1980                
Gly Leu Ser Ala Ala Asp Leu Asp Phe Ala Ala Ser Leu Leu Gly Thr
1985                1990                1995                2000
Glu Pro Phe Gln Glu Glu Ile Val Ala Ala Gly Ala Met Gly Ser Ser
                2005                2010                2015    
His Gly Gly Pro Gly Asp Ser Ser Glu Glu Glu Ser Ser Pro Thr Ser
            2020                2025                2030        
Arg Tyr Ile His Phe Pro Val Thr Val Val Ser Ala Pro Gly Leu Ala
        2035                2040                2045            
Pro Ser Ala Thr Pro Gly Ala Pro Arg Ile Glu Gln Leu Asp Gly Val
    2050                2055                2060                
Asp Asp Gly Thr Asp Ser Glu Ala Glu Ala Val Gln Gln Pro Arg Gly
2065                2070                2075                2080
Gln Gly Thr Pro Pro Ser Gly Pro Gly Val Val Arg Ala Gly Val Leu
                2085                2090                2095    
Gly Ala Ala Gly Asp Arg Ala Arg Pro Pro Glu Asp Leu Pro Ser Glu
            2100                2105                2110        
Ile Val Asp Phe Val Leu Lys Asn Leu Gly Gly Pro Gly Asp Gly Gly
        2115                2120                2125            
Ala Gly Pro Arg Glu Glu Ser Leu Pro Pro Ala Pro Pro Leu Ala Asn
    2130                2135                2140                
Gly Ser Gln Pro Ser Gln Gly Leu Thr Ala Ser Pro Ala Asp Pro Thr
2145                2150                2155                2160
Arg Thr Phe Ala Trp Leu Pro Gly Ala Pro Gly Val Arg Val Leu Ser
                2165                2170                2175    
Leu Gly Pro Ala Pro Glu Pro Pro Lys Pro Ala Thr Ser Lys Ile Ile
            2180                2185                2190        
Leu Val Asn Lys Leu Gly Gln Val Phe Val Lys Met Ala Gly Glu Gly
        2195                2200                2205            
Glu Pro Val Pro Pro Pro Val Lys Gln Pro Pro Leu Pro Pro Thr Ile
    2210                2215                2220                
Ser Pro Thr Ala Pro Thr Ser Trp Thr Leu Pro Pro Gly Pro Leu Leu
2225                2230                2235                2240
Gly Val Leu Pro Val Val Gly Val Val Arg Pro Ala Pro Pro Pro Pro
                2245                2250                2255    
Pro Pro Pro Leu Thr Leu Val Leu Ser Ser Gly Pro Ala Ser Pro Pro
            2260                2265                2270        
Arg Gln Ala Ile Arg Val Lys Arg Val Ser Thr Phe Ser Gly Arg Ser
        2275                2280                2285            
Pro Pro Ala Pro Pro Pro Tyr Lys Ala Pro Arg Leu Asp Glu Asp Gly
    2290                2295                2300                
Glu Ala Ser Glu Asp Thr Pro Gln Val Pro Gly Leu Gly Ser Gly Gly
2305                2310                2315                2320
Phe Ser Arg Val Arg Met Lys Thr Pro Thr Val Arg Gly Val Leu Asp
                2325                2330                2335    
Leu Asp Arg Pro Gly Glu Pro Ala Gly Glu Glu Ser Pro Gly Pro Leu
            2340                2345                2350        
Gln Glu Arg Ser Pro Leu Leu Pro Leu Pro Glu Asp Gly Pro Pro Gln
        2355                2360                2365            
Val Pro Asp Gly Pro Pro Asp Leu Leu Leu Glu Ser Gln Trp His His
    2370                2375                2380                
Tyr Ser Gly Glu Ala Ser Ser Ser Glu Glu Glu Pro Pro Ser Pro Asp
2385                2390                2395                2400
Asp Lys Glu Asn Gln Ala Pro Lys Arg Thr Gly Pro His Leu Arg Phe
                2405                2410                2415    
Glu Ile Ser Ser Glu Asp Gly Phe Ser Val Glu Ala Glu Ser Leu Glu
            2420                2425                2430        
Gly Ala Trp Arg Thr Leu Ile Glu Lys Val Gln Glu Ala Arg Gly His
        2435                2440                2445            
Ala Arg Leu Arg His Leu Ser Phe Ser Gly Met Ser Gly Ala Arg Leu
    2450                2455                2460                
Leu Gly Ile His His Asp Ala Val Ile Phe Leu Ala Glu Gln Leu Pro
2465                2470                2475                2480
Gly Ala Gln Arg Cys Gln His Tyr Lys Phe Arg Tyr His Gln Gln Gly
                2485                2490                2495    
Glu Gly Gln Glu Glu Pro Pro Leu Asn Pro His Gly Ala Ala Arg Ala
            2500                2505                2510        
Glu Val Tyr Leu Arg Lys Cys Thr Phe Asp Met Phe Asn Phe Leu Ala
        2515                2520                2525            
Ser Gln His Arg Val Leu Pro Glu Gly Ala Thr Cys Asp Glu Glu Glu
    2530                2535                2540                
Asp Glu Val Gln Leu Arg Ser Thr Arg Arg Ala Thr Ser Leu Glu Leu
2545                2550                2555                2560
Pro Met Ala Met Arg Phe Arg His Leu Lys Lys Thr Ser Lys Glu Ala
                2565                2570                2575    
Val Gly Val Tyr Arg Ser Ala Ile His Gly Arg Gly Leu Phe Cys Lys
            2580                2585                2590        
Arg Asn Ile Asp Ala Gly Glu Met Val Ile Glu Tyr Ser Gly Ile Val
        2595                2600                2605            
Ile Arg Ser Val Leu Thr Asp Lys Arg Glu Lys Phe Tyr Asp Gly Lys
    2610                2615                2620                
Gly Ile Gly Cys Tyr Met Phe Arg Met Asp Asp Phe Asp Val Val Asp
2625                2630                2635                2640
Ala Thr Met His Gly Asn Ala Ala Arg Phe Ile Asn His Ser Cys Glu
                2645                2650                2655    
Pro Asn Cys Phe Ser Arg Val Ile His Val Glu Gly Gln Lys His Ile
            2660                2665                2670        
Val Ile Phe Ala Leu Arg Arg Ile Leu Arg Gly Glu Glu Leu Thr Tyr
        2675                2680                2685            
Asp Tyr Lys Phe Pro Ile Glu Asp Ala Ser Asn Lys Leu Pro Cys Asn
    2690                2695                2700                
Cys Gly Ala Lys Arg Cys Arg Arg Phe Leu Asn
2705                2710                2715


<210> 867
<211> 1300
<212> PRT
<213> Homo sapiens

<400> 867
Met Glu Glu Ala Ser Leu Cys Leu Gly Val Ser Ser Ala Glu Pro Glu
 1               5                  10                  15      
Ala Glu Pro His Leu Ser Gly Pro Val Leu Asn Gly Gln Tyr Ala Met
            20                  25                  30          
Ser Gln Lys Leu His Gln Ile Thr Ser Gln Leu Ser His Ala Phe Pro
        35                  40                  45              
Glu Leu His Pro Arg Pro Asn Pro Glu Glu Lys Pro Pro Ala Ser Leu
    50                  55                  60                  
Glu Glu Lys Ala His Val Pro Met Ser Gly Gln Pro Met Gly Ser Gln
65                  70                  75                  80  
Met Ala Leu Leu Ala Asn Gln Leu Gly Arg Glu Val Asp Thr Ser Leu
                85                  90                  95      
Asn Gly Arg Val Asp Leu Gln Gln Phe Leu Asn Gly Gln Asn Leu Gly
            100                 105                 110         
Ile Met Ser Gln Met Ser Asp Ile Glu Asp Asp Ala Arg Lys Asn Arg
        115                 120                 125             
Lys Tyr Pro Cys Pro Leu Cys Gly Lys Arg Phe Arg Phe Asn Ser Ile
    130                 135                 140                 
Leu Ser Leu His Met Arg Thr His Thr Gly Glu Lys Pro Phe Lys Cys
145                 150                 155                 160 
Pro Tyr Cys Asp His Arg Ala Ala Gln Lys Gly Asn Leu Lys Ile His
                165                 170                 175     
Leu Arg Thr His Lys Leu Gly Asn Leu Gly Lys Gly Arg Gly Arg Val
            180                 185                 190         
Arg Glu Glu Asn Arg Leu Leu His Glu Leu Glu Glu Arg Ala Ile Leu
        195                 200                 205             
Arg Asp Lys Gln Leu Lys Gly Ser Leu Leu Gln Pro Arg Pro Asp Leu
    210                 215                 220                 
Lys Pro Pro Pro His Ala Gln Gln Ala Pro Leu Ala Ala Cys Thr Leu
225                 230                 235                 240 
Ala Leu Gln Ala Asn His Ser Val Pro Asp Val Ala His Pro Val Pro
                245                 250                 255     
Ser Pro Lys Pro Ala Ser Val Gln Glu Asp Ala Val Ala Pro Ala Ala
            260                 265                 270         
Gly Phe Arg Cys Thr Phe Cys Lys Gly Lys Phe Lys Lys Arg Glu Glu
        275                 280                 285             
Leu Asp Arg His Ile Arg Ile Leu His Lys Pro Tyr Lys Cys Thr Leu
    290                 295                 300                 
Cys Asp Phe Ala Ala Ser Gln Glu Glu Glu Leu Ile Ser His Val Glu
305                 310                 315                 320 
Lys Ala His Ile Thr Ala Glu Ser Ala Gln Gly Gln Gly Pro Asn Gly
                325                 330                 335     
Gly Gly Glu Gln Ser Ala Asn Glu Phe Arg Cys Glu Val Cys Gly Gln
            340                 345                 350         
Val Phe Ser Gln Ala Trp Phe Leu Lys Gly His Met Arg Lys His Lys
        355                 360                 365             
Asp Ser Phe Glu His Cys Cys Gln Ile Cys Gly Arg Arg Phe Lys Glu
    370                 375                 380                 
Pro Trp Phe Leu Lys Asn His Met Lys Val His Leu Asn Lys Leu Ser
385                 390                 395                 400 
Val Lys Asn Lys Ser Pro Ser Asp Pro Glu Val Pro Val Pro Met Gly
                405                 410                 415     
Gly Met Ser Gln Glu Ala His Ala Asn Leu Tyr Ser Arg Tyr Leu Ser
            420                 425                 430         
Cys Leu Gln Ser Gly Phe Met Thr Pro Asp Lys Ala Gly Leu Ser Glu
        435                 440                 445             
Pro Ser Gln Leu Tyr Gly Lys Gly Glu Leu Pro Met Lys Glu Lys Glu
    450                 455                 460                 
Ala Leu Gly Lys Leu Leu Ser Pro Ile Ser Ser Met Ala His Gly Val
465                 470                 475                 480 
Pro Glu Gly Asp Lys His Ser Leu Leu Gly Cys Leu Asn Leu Val Pro
                485                 490                 495     
Pro Leu Lys Ser Ser Cys Ile Glu Arg Leu Gln Ala Ala Ala Lys Ala
            500                 505                 510         
Ala Glu Met Asp Pro Val Asn Ser Tyr Gln Ala Trp Gln Leu Met Ala
        515                 520                 525             
Arg Gly Met Ala Met Glu His Gly Phe Leu Ser Lys Glu His Pro Leu
    530                 535                 540                 
Gln Arg Asn His Glu Asp Thr Leu Ala Asn Ala Gly Val Leu Phe Asp
545                 550                 555                 560 
Lys Glu Lys Arg Glu Tyr Val Leu Val Gly Ala Asp Gly Ser Lys Gln
                565                 570                 575     
Lys Met Pro Ala Asp Leu Val His Ser Thr Lys Val Gly Ser Gln Arg
            580                 585                 590         
Asp Leu Pro Ser Lys Leu Asp Pro Leu Glu Ser Ser Arg Asp Phe Leu
        595                 600                 605             
Ser His Gly Leu Asn Gln Thr Leu Glu Tyr Asn Leu Gln Gly Pro Gly
    610                 615                 620                 
Asn Met Lys Glu Lys Pro Thr Glu Cys Pro Asp Cys Gly Arg Val Phe
625                 630                 635                 640 
Arg Thr Tyr His Gln Val Val Val His Ser Arg Val His Lys Arg Asp
                645                 650                 655     
Arg Lys Gly Glu Glu Asp Gly Leu His Val Gly Leu Asp Glu Arg Arg
            660                 665                 670         
Gly Ser Gly Ser Asp Gln Glu Ser Gln Ser Val Ser Arg Ser Thr Thr
        675                 680                 685             
Pro Gly Ser Ser Asn Val Thr Glu Glu Ser Gly Val Gly Gly Gly Leu
    690                 695                 700                 
Ser Gln Thr Gly Ser Ala Gln Glu Asp Ser Pro His Pro Ser Ser Pro
705                 710                 715                 720 
Ser Ser Ser Asp Ile Gly Glu Glu Ala Gly Arg Ser Ala Gly Val Gln
                725                 730                 735     
Gln Pro Ala Leu Leu Arg Asp Arg Ser Leu Gly Ser Ala Met Lys Asp
            740                 745                 750         
Cys Pro Tyr Cys Gly Lys Thr Phe Arg Thr Ser His His Leu Lys Val
        755                 760                 765             
His Leu Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Pro His Cys
    770                 775                 780                 
Asp Tyr Ala Gly Thr Gln Ser Ala Ser Leu Lys Tyr His Leu Glu Arg
785                 790                 795                 800 
His His Arg Glu Arg Gln Asn Gly Ala Gly Pro Leu Ser Gly Gln Pro
                805                 810                 815     
Pro Asn Gln Asp His Lys Asp Glu Met Ser Ser Lys Ala Ser Leu Phe
            820                 825                 830         
Ile Arg Pro Asp Ile Leu Arg Gly Ala Phe Lys Gly Leu Pro Gly Ile
        835                 840                 845             
Asp Phe Arg Gly Gly Pro Ala Ser Gln Gln Trp Thr Ser Gly Val Leu
    850                 855                 860                 
Ser Ser Gly Asp His Ser Gly Gln Ala Thr Gly Met Ser Ser Glu Val
865                 870                 875                 880 
Pro Ser Asp Ala Leu Lys Gly Thr Asp Leu Pro Ser Lys Ser Thr His
                885                 890                 895     
Phe Ser Glu Ile Gly Arg Ala Tyr Gln Ser Ile Val Ser Asn Gly Val
            900                 905                 910         
Asn Phe Gln Gly Ser Leu Gln Ala Phe Met Asp Ser Phe Val Leu Ser
        915                 920                 925             
Ser Leu Lys Lys Glu Lys Asp Met Lys Asp Lys Ala Leu Ala Asp Pro
    930                 935                 940                 
Pro Ser Met Lys Val His Gly Val Asp Gly Gly Glu Glu Lys Pro Ser
945                 950                 955                 960 
Gly Lys Ser Ser Gln Arg Lys Ser Glu Lys Ser Gln Tyr Glu Pro Leu
                965                 970                 975     
Asp Leu Ser Val Arg Pro Asp Ala Ala Ser Leu Pro Gly Ser Ser Val
            980                 985                 990         
Thr Val Gln Asp Ser Ile Ala Trp His Gly Cys Leu Phe Cys Ala Phe
        995                 1000                1005            
Thr Thr Ser Ser Met Glu Leu Met Ala Leu His Leu Gln Ala Asn His
    1010                1015                1020                
Leu Gly Lys Ala Lys Arg Lys Asp Asn Thr Ile Gly Val Thr Val Asn
1025                1030                1035                1040
Cys Lys Asp Gln Ala Arg Glu Ala Ser Lys Met Ala Leu Leu Pro Ser
                1045                1050                1055    
Leu Gln Ser Asn Lys Asp Leu Gly Leu Ser Asn Met Ile Ser Ser Leu
            1060                1065                1070        
Asp Ser Ala Ser Glu Lys Met Ala Gln Gly Gln Leu Lys Glu Thr Leu
        1075                1080                1085            
Gly Glu Gln Lys Ser Gly Ala Trp Thr Gly His Val Asp Pro Ala Phe
    1090                1095                1100                
Cys Asn Phe Pro Ser Asp Phe Tyr Lys Gln Phe Gly Val Tyr Pro Gly
1105                1110                1115                1120
Met Val Gly Ser Gly Ala Ser Ser Ser Cys Pro Asn Lys Glu Pro Asp
                1125                1130                1135    
Gly Lys Ala His Ser Glu Glu Asp Val Pro Ile Leu Ile Pro Glu Thr
            1140                1145                1150        
Thr Ser Lys Asn Thr Thr Asp Asp Leu Ser Asp Ile Ala Ser Ser Glu
        1155                1160                1165            
Asp Met Asp Ser Ser Lys Gly Glu Asn Asn Asp Glu Glu Asp Val Glu
    1170                1175                1180                
Thr Glu Pro Glu Met Met Thr Lys Pro Leu Ser Ala Leu Ser Lys Asp
1185                1190                1195                1200
Ser Ser Ser Asp Gly Gly Asp Ser Leu Gln Pro Thr Gly Thr Ser Gln
                1205                1210                1215    
Pro Val Gln Gly Leu Val Ser Pro Leu Ser Gln Ala Pro Glu Lys Gln
            1220                1225                1230        
Trp His Ser Gln Gly Leu Leu Gln Ala Gln Asp Pro Leu Ala Gly Leu
        1235                1240                1245            
Pro Lys Pro Glu Arg Gly Pro Gln Ser Leu Asp Lys Pro Met Asn Met
    1250                1255                1260                
Leu Ser Val Leu Arg Ala Tyr Ser Ser Asp Gly Leu Ala Ala Phe Asn
1265                1270                1275                1280
Gly Leu Ala Ser Ser Thr Ala Asn Ser Gly Cys Ile Lys Arg Pro Asp
                1285                1290                1295    
Leu Cys Gly Lys
            1300


<210> 868
<211> 1047
<212> PRT
<213> Homo sapiens

<400> 868
Met Asp Ala Glu Ala Glu Asp Lys Thr Leu Arg Thr Arg Ser Lys Gly
 1               5                  10                  15      
Thr Glu Val Pro Met Asp Ser Leu Ile Gln Glu Leu Ser Val Ala Tyr
            20                  25                  30          
Asp Cys Ser Met Ala Lys Lys Arg Thr Ala Glu Asp Gln Ala Leu Gly
        35                  40                  45              
Val Pro Val Asn Lys Arg Lys Ser Leu Leu Met Lys Pro Arg His Tyr
    50                  55                  60                  
Ser Pro Lys Ala Asp Cys Gln Glu Asp Arg Ser Asp Arg Thr Glu Asp
65                  70                  75                  80  
Asp Gly Pro Leu Glu Thr His Gly His Ser Thr Ala Glu Glu Ile Met
                85                  90                  95      
Ile Lys Pro Met Asp Glu Ser Leu Leu Ser Thr Ala Gln Glu Asn Ser
            100                 105                 110         
Ser Arg Lys Glu Asp Arg Tyr Ser Cys Tyr Gln Glu Leu Met Val Lys
        115                 120                 125             
Ser Leu Met His Leu Gly Lys Phe Glu Lys Asn Val Ser Val Gln Thr
    130                 135                 140                 
Val Ser Glu Asn Leu Asn Asp Ser Gly Ile Gln Ser Leu Lys Ala Glu
145                 150                 155                 160 
Ser Asp Glu Ala Asp Glu Cys Phe Leu Ile His Ser Asp Asp Gly Arg
                165                 170                 175     
Asp Lys Ile Asp Asp Ser Gln Pro Pro Phe Cys Ser Ser Asp Asp Asn
            180                 185                 190         
Glu Ser Asn Ser Glu Ser Ala Glu Asn Gly Trp Asp Ser Gly Ser Asn
        195                 200                 205             
Phe Ser Glu Glu Thr Lys Pro Pro Arg Val Pro Lys Tyr Val Leu Thr
    210                 215                 220                 
Asp His Lys Lys Asp Leu Leu Glu Val Pro Glu Ile Lys Thr Glu Gly
225                 230                 235                 240 
Asp Lys Phe Ile Pro Cys Glu Asn Arg Cys Asp Ser Glu Thr Glu Arg
                245                 250                 255     
Lys Asp Pro Gln Asn Ala Leu Ala Glu Pro Leu Asp Gly Asn Ala Gln
            260                 265                 270         
Pro Ser Phe Pro Asp Val Glu Glu Glu Asp Ser Glu Ser Leu Ala Val
        275                 280                 285             
Met Thr Glu Glu Gly Ser Asp Leu Glu Lys Ala Lys Gly Asn Leu Ser
    290                 295                 300                 
Leu Leu Glu Gln Ala Ile Ala Leu Gln Ala Glu Arg Gly Cys Val Phe
305                 310                 315                 320 
His Asn Thr Tyr Lys Glu Leu Asp Arg Phe Leu Leu Glu His Leu Ala
                325                 330                 335     
Gly Glu Arg Arg Gln Thr Lys Val Ile Asp Met Gly Gly Arg Gln Ile
            340                 345                 350         
Phe Asn Asn Lys His Ser Pro Arg Pro Glu Lys Arg Glu Thr Lys Cys
        355                 360                 365             
Pro Ile Pro Gly Cys Asp Gly Thr Gly His Val Thr Gly Leu Tyr Pro
    370                 375                 380                 
His His Arg Ser Leu Ser Gly Cys Pro His Lys Val Arg Val Pro Leu
385                 390                 395                 400 
Glu Ile Leu Ala Met His Glu Asn Val Leu Lys Cys Pro Thr Pro Gly
                405                 410                 415     
Cys Thr Gly Arg Gly His Val Asn Ser Asn Arg Asn Thr His Arg Ser
            420                 425                 430         
Leu Ser Gly Cys Pro Ile Ala Ala Ala Glu Lys Leu Ala Met Ser Gln
        435                 440                 445             
Asp Lys Asn Gln Leu Asp Ser Pro Gln Thr Gly Gln Cys Pro Asp Gln
    450                 455                 460                 
Ala His Arg Thr Ser Leu Val Lys Gln Ile Glu Phe Asn Phe Pro Ser
465                 470                 475                 480 
Gln Ala Ile Thr Ser Pro Arg Ala Thr Val Ser Lys Glu Gln Glu Lys
                485                 490                 495     
Phe Gly Lys Val Pro Phe Asp Tyr Ala Ser Phe Asp Ala Gln Val Phe
            500                 505                 510         
Gly Lys Arg Pro Leu Ile Gln Thr Val Gln Gly Arg Lys Thr Pro Pro
        515                 520                 525             
Phe Pro Glu Ser Lys His Phe Pro Asn Pro Val Lys Phe Pro Asn Arg
    530                 535                 540                 
Leu Pro Ser Ala Gly Ala His Thr Gln Ser Pro Gly Arg Ala Ser Ser
545                 550                 555                 560 
Tyr Ser Tyr Gly Gln Cys Ser Glu Asp Thr His Ile Ala Ala Ala Ala
                565                 570                 575     
Ala Ile Leu Asn Leu Ser Thr Arg Cys Arg Glu Ala Thr Asp Ile Leu
            580                 585                 590         
Ser Asn Lys Pro Gln Ser Leu His Ala Lys Gly Ala Glu Ile Glu Val
        595                 600                 605             
Asp Glu Asn Gly Thr Leu Asp Leu Ser Met Lys Lys Asn Arg Ile Leu
    610                 615                 620                 
Asp Lys Ser Ala Pro Leu Thr Ser Ser Asn Thr Ser Ile Pro Thr Pro
625                 630                 635                 640 
Ser Ser Ser Pro Phe Lys Thr Ser Ser Ile Leu Val Asn Ala Ala Phe
                645                 650                 655     
Tyr Gln Ala Leu Cys Asp Gln Glu Gly Trp Asp Thr Pro Ile Asn Tyr
            660                 665                 670         
Ser Lys Thr His Gly Lys Thr Glu Glu Glu Lys Glu Lys Asp Pro Val
        675                 680                 685             
Ser Ser Leu Glu Asn Leu Glu Glu Lys Lys Phe Pro Gly Glu Ala Ser
    690                 695                 700                 
Ile Pro Ser Pro Lys Pro Lys Leu His Ala Arg Asp Leu Lys Lys Glu
705                 710                 715                 720 
Leu Ile Thr Cys Pro Thr Pro Gly Cys Asp Gly Ser Gly His Val Thr
                725                 730                 735     
Gly Asn Tyr Ala Ser His Arg Ser Val Ser Gly Cys Pro Leu Ala Asp
            740                 745                 750         
Lys Thr Leu Lys Ser Leu Met Ala Ala Asn Ser Gln Glu Leu Lys Cys
        755                 760                 765             
Pro Thr Pro Gly Cys Asp Gly Ser Gly His Val Thr Gly Asn Tyr Ala
    770                 775                 780                 
Ser His Arg Ser Leu Ser Gly Cys Pro Arg Ala Arg Lys Gly Gly Val
785                 790                 795                 800 
Lys Met Thr Pro Thr Lys Glu Glu Lys Glu Asp Pro Glu Leu Lys Cys
                805                 810                 815     
Pro Val Ile Gly Cys Asp Gly Gln Gly His Ile Ser Gly Lys Tyr Thr
            820                 825                 830         
Ser His Arg Thr Ala Ser Gly Cys Pro Leu Ala Ala Lys Arg Gln Lys
        835                 840                 845             
Glu Asn Pro Leu Asn Gly Ala Ser Leu Ser Trp Lys Leu Asn Lys Gln
    850                 855                 860                 
Glu Leu Pro His Cys Pro Leu Pro Gly Cys Asn Gly Leu Gly His Val
865                 870                 875                 880 
Asn Asn Val Phe Val Thr His Arg Ser Leu Ser Gly Cys Pro Leu Asn
                885                 890                 895     
Ala Gln Val Ile Lys Lys Gly Lys Val Ser Glu Glu Leu Met Thr Ile
            900                 905                 910         
Lys Leu Lys Ala Thr Gly Gly Ile Glu Ser Asp Glu Glu Ile Arg His
        915                 920                 925             
Leu Asp Glu Glu Ile Lys Glu Leu Asn Glu Ser Asn Leu Lys Ile Glu
    930                 935                 940                 
Ala Asp Met Met Lys Leu Gln Thr Gln Ile Thr Ser Met Glu Ser Asn
945                 950                 955                 960 
Leu Lys Thr Ile Glu Glu Glu Asn Lys Leu Ile Glu Gln Asn Asn Glu
                965                 970                 975     
Ser Leu Leu Lys Glu Leu Ala Gly Leu Ser Gln Ala Leu Ile Ser Ser
            980                 985                 990         
Leu Ala Asp Ile Gln Leu Pro Gln Met Gly Pro Ile Ser Glu Gln Asn
        995                 1000                1005            
Phe Glu Ala Tyr Val Asn Thr Leu Thr Asp Met Tyr Ser Asn Leu Glu
    1010                1015                1020                
Arg Asp Tyr Ser Pro Glu Cys Lys Ala Leu Leu Glu Ser Ile Lys Gln
1025                1030                1035                1040
Ala Val Lys Gly Ile His Val
                1045        


<210> 869
<211> 1533
<212> PRT
<213> Homo sapiens

<400> 869
Met Pro Val Lys Arg Leu Arg Glu Val Val Ser Gln Asn His Gly Asp
 1               5                  10                  15      
His Leu Val Leu Leu Lys Asp Glu Leu Pro Cys Val Pro Pro Ala Leu
            20                  25                  30          
Ser Ala Asn Lys Arg Leu Pro Val Gly Thr Gly Thr Ser Leu Asn Gly
        35                  40                  45              
Thr Ser Arg Gly Ser Ser Asp Leu Thr Ser Ala Arg Asn Cys Tyr Gln
    50                  55                  60                  
Pro Leu Leu Glu Asn Pro Met Val Ser Glu Ser Asp Phe Ser Lys Asp
65                  70                  75                  80  
Val Ala Val Gln Val Leu Pro Leu Asp Lys Ile Glu Glu Asn Asn Lys
                85                  90                  95      
Gln Lys Ala Asn Asp Ile Phe Ile Ser Gln Tyr Thr Met Gly Gln Lys
            100                 105                 110         
Asp Ala Leu Arg Thr Val Leu Lys Gln Lys Ala Gln Ser Met Pro Val
        115                 120                 125             
Phe Lys Glu Val Lys Val His Leu Leu Glu Asp Ala Gly Ile Glu Lys
    130                 135                 140                 
Asp Ala Val Thr Gln Glu Thr Arg Ile Ser Pro Ser Gly Ile Asp Ser
145                 150                 155                 160 
Ala Thr Thr Val Ala Ala Ala Thr Ala Ala Ala Ile Ala Thr Ala Ala
                165                 170                 175     
Pro Leu Ile Lys Val Gln Ser Asp Leu Glu Ala Lys Val Asn Ser Val
            180                 185                 190         
Thr Glu Leu Leu Ser Lys Leu Gln Glu Thr Asp Lys His Leu Gln Arg
        195                 200                 205             
Val Thr Glu Gln Gln Thr Ser Ile Gln Arg Lys Gln Glu Lys Leu His
    210                 215                 220                 
Cys His Asp His Glu Lys Gln Met Asn Val Phe Met Glu Gln His Ile
225                 230                 235                 240 
Arg His Leu Glu Lys Leu Gln Gln Gln Gln Ile Asp Ile Gln Thr His
                245                 250                 255     
Phe Ile Ser Ala Ala Leu Lys Thr Ser Ser Phe Gln Pro Val Ser Met
            260                 265                 270         
Pro Ser Ser Arg Ala Val Glu Lys Tyr Ser Val Lys Pro Glu His Pro
        275                 280                 285             
Asn Leu Gly Ser Cys Asn Pro Ser Leu Tyr Asn Thr Phe Ala Ser Lys
    290                 295                 300                 
Gln Ala Pro Leu Lys Glu Val Glu Asp Thr Ser Phe Asp Lys Gln Lys
305                 310                 315                 320 
Ser Pro Leu Glu Thr Pro Ala Pro Arg Arg Phe Ala Pro Val Pro Val
                325                 330                 335     
Ser Arg Asp Asp Glu Leu Ser Lys Arg Glu Asn Leu Leu Glu Glu Lys
            340                 345                 350         
Glu Asn Met Glu Val Ser Cys His Arg Gly Asn Val Arg Leu Leu Glu
        355                 360                 365             
Gln Ile Leu Asn Asn Asn Asp Ser Leu Thr Arg Lys Ser Glu Ser Ser
    370                 375                 380                 
Asn Thr Thr Ser Leu Thr Arg Ser Lys Ile Gly Trp Thr Pro Glu Lys
385                 390                 395                 400 
Thr Asn Arg Phe Pro Ser Cys Glu Glu Leu Glu Thr Thr Lys Val Thr
                405                 410                 415     
Met Gln Lys Ser Asp Asp Val Leu His Asp Leu Gly Gln Lys Glu Lys
            420                 425                 430         
Glu Thr Asn Ser Met Val Gln Pro Lys Glu Ser Leu Ser Met Leu Lys
        435                 440                 445             
Leu Pro Asp Leu Pro Gln Asn Ser Val Lys Leu Gln Thr Thr Asn Thr
    450                 455                 460                 
Thr Arg Ser Val Leu Lys Asp Ala Glu Lys Ile Leu Arg Gly Val Gln
465                 470                 475                 480 
Asn Asn Lys Lys Val Leu Glu Glu Asn Leu Glu Ala Ile Ile Arg Ala
                485                 490                 495     
Lys Asp Gly Ala Ala Met Tyr Ser Leu Ile Asn Ala Leu Ser Thr Asn
            500                 505                 510         
Arg Glu Met Ser Glu Lys Ile Arg Ile Arg Lys Thr Val Asp Glu Trp
        515                 520                 525             
Ile Lys Thr Ile Ser Ala Glu Ile Gln Asp Glu Leu Ser Arg Thr Asp
    530                 535                 540                 
Tyr Glu Gln Lys Arg Phe Asp Gln Lys Asn Gln Arg Thr Lys Lys Gly
545                 550                 555                 560 
Gln Asn Met Thr Lys Asp Ile Arg Thr Asn Thr Gln Asp Lys Thr Val
                565                 570                 575     
Asn Lys Ser Val Ile Pro Arg Lys His Ser Gln Lys Gln Ile Glu Glu
            580                 585                 590         
His Phe Arg Asn Leu Pro Met Arg Gly Met Pro Ala Ser Ser Leu Gln
        595                 600                 605             
Lys Glu Arg Lys Glu Gly Leu Leu Lys Ala Thr Thr Val Ile Gln Asp
    610                 615                 620                 
Glu Asp Tyr Met Leu Gln Val Tyr Gly Lys Pro Val Tyr Gln Gly His
625                 630                 635                 640 
Arg Ser Thr Leu Lys Lys Gly Pro Tyr Leu Arg Phe Asn Ser Pro Ser
                645                 650                 655     
Pro Lys Ser Arg Pro Gln Arg Pro Lys Val Ile Glu Arg Val Lys Gly
            660                 665                 670         
Thr Lys Val Lys Ser Ile Arg Thr Gln Thr Asp Phe Tyr Ala Thr Lys
        675                 680                 685             
Pro Lys Lys Met Asp Ser Lys Met Lys His Ser Val Pro Val Leu Pro
    690                 695                 700                 
His Gly Asp Gln Gln Tyr Leu Phe Ser Pro Ser Arg Glu Met Pro Thr
705                 710                 715                 720 
Phe Ser Gly Thr Leu Glu Gly His Leu Ile Pro Met Ala Ile Leu Leu
                725                 730                 735     
Gly Gln Thr Gln Ser Asn Ser Asp Thr Met Pro Pro Ala Gly Val Ile
            740                 745                 750         
Val Ser Lys Pro His Pro Val Thr Val Thr Thr Ser Ile Pro Pro Ser
        755                 760                 765             
Ser Arg Lys Val Glu Thr Gly Val Lys Lys Pro Asn Ile Ala Ile Val
    770                 775                 780                 
Glu Met Lys Ser Glu Lys Lys Asp Pro Pro Gln Leu Thr Val Gln Val
785                 790                 795                 800 
Leu Pro Ser Val Asp Ile Asp Ser Ile Ser Asn Ser Ser Ala Asp Val
                805                 810                 815     
Leu Ser Pro Leu Ser Ser Pro Lys Glu Ala Ser Pro Pro Pro Val Gln
            820                 825                 830         
Thr Trp Ile Lys Thr Pro Glu Ile Met Lys Val Asp Glu Glu Glu Val
        835                 840                 845             
Lys Phe Pro Gly Thr Asn Phe Asp Glu Ile Ile Asp Val Ile Gln Glu
    850                 855                 860                 
Glu Glu Lys Cys Asp Glu Ile Pro Asp Ser Glu Pro Ile Leu Glu Phe
865                 870                 875                 880 
Asn Arg Ser Val Lys Ala Asp Ser Thr Lys Tyr Asn Gly Pro Pro Phe
                885                 890                 895     
Pro Pro Val Ala Ser Thr Phe Gln Pro Thr Ala Asp Ile Leu Asp Lys
            900                 905                 910         
Val Ile Glu Arg Lys Glu Thr Leu Glu Asn Ser Leu Ile Gln Trp Val
        915                 920                 925             
Glu Gln Glu Ile Met Ser Arg Ile Ile Ser Gly Leu Phe Pro Val Gln
    930                 935                 940                 
Gln Gln Ile Ala Pro Ser Ile Ser Val Ser Val Ser Glu Thr Ser Glu
945                 950                 955                 960 
Pro Leu Thr Ser Asp Ile Val Glu Gly Thr Ser Ser Gly Ala Leu Gln
                965                 970                 975     
Leu Phe Val Asp Ala Gly Val Pro Val Asn Ser Asn Val Ile Lys His
            980                 985                 990         
Phe Val Asn Glu Ala Leu Ala Glu Thr Ile Ala Val Met Leu Gly Asp
        995                 1000                1005            
Arg Glu Ala Lys Lys Gln Gly Pro Val Ala Thr Gly Val Ser Gly Asp
    1010                1015                1020                
Ala Ser Thr Asn Glu Thr Tyr Leu Pro Ala Arg Val Cys Thr Pro Leu
1025                1030                1035                1040
Ala Thr Pro Gln Pro Thr Pro Pro Cys Ser Pro Ser Ser Pro Ala Lys
                1045                1050                1055    
Glu Cys Val Leu Val Lys Thr Pro Asp Ser Ser Pro Cys Asp Ser Asp
            1060                1065                1070        
His Asp Met Ala Phe Pro Val Lys Glu Ile Cys Ala Glu Lys Gly Asp
        1075                1080                1085            
Asp Met Pro Ala Ile Met Leu Val Asn Thr Pro Thr Val Thr Pro Thr
    1090                1095                1100                
Thr Thr Pro Pro Pro Ala Ala Ala Val Phe Thr Pro Thr Leu Ser Asp
1105                1110                1115                1120
Ile Ser Ile Asp Lys Leu Lys Val Ser Ser Pro Glu Leu Pro Lys Pro
                1125                1130                1135    
Trp Gly Asp Gly Asp Leu Pro Leu Glu Glu Glu Asn Pro Asn Ser Pro
            1140                1145                1150        
Gln Glu Glu Leu His Pro Arg Ala Ile Val Met Ser Val Ala Lys Asp
        1155                1160                1165            
Glu Glu Pro Glu Ser Met Asp Phe Pro Ala Gln Pro Pro Pro Pro Glu
    1170                1175                1180                
Pro Val Pro Phe Met Pro Phe Pro Ala Gly Thr Lys Ala Pro Ser Pro
1185                1190                1195                1200
Ser Gln Met Pro Gly Ser Asp Ser Ser Thr Leu Glu Ser Thr Leu Ser
                1205                1210                1215    
Val Thr Val Thr Glu Thr Glu Thr Leu Asp Lys Pro Ile Ser Glu Gly
            1220                1225                1230        
Glu Ile Leu Phe Ser Cys Gly Gln Lys Leu Ala Pro Lys Ile Leu Glu
        1235                1240                1245            
Asp Ile Gly Leu Tyr Leu Thr Asn Leu Asn Asp Ser Leu Ser Ser Thr
    1250                1255                1260                
Leu His Asp Ala Val Glu Met Glu Asp Asp Pro Pro Ser Glu Gly Gln
1265                1270                1275                1280
Val Ile Arg Met Ser His Lys Lys Phe His Ala Asp Ala Ile Leu Ser
                1285                1290                1295    
Phe Ala Lys Gln Asn Gln Glu Ser Ala Val Ser Gln Gln Ala Val Tyr
            1300                1305                1310        
His Ser Glu Asp Leu Glu Asn Ser Val Gly Glu Leu Ser Glu Gly Gln
        1315                1320                1325            
Arg Pro Gln Leu Thr Ala Ala Ala Glu Asn Ile Leu Met Gly His Ser
    1330                1335                1340                
Leu Tyr Met Gln Pro Pro Val Thr Asn Thr Gln Ser Leu Asp Gln Gln
1345                1350                1355                1360
Cys Asp Pro Lys Pro Leu Ser Arg Gln Phe Asp Thr Val Ser Gly Ser
                1365                1370                1375    
Ile Tyr Glu Asp Ser Cys Ala Ser His Gly Pro Met Ser Leu Gly Glu
            1380                1385                1390        
Leu Glu Leu Glu Pro Asn Ser Lys Leu Val Leu Pro Thr Thr Leu Leu
        1395                1400                1405            
Thr Ala Gln Glu Asn Asp Val Asn Leu Pro Val Ala Ala Glu Asp Phe
    1410                1415                1420                
Ser Gln Tyr Gln Leu Lys Gln Asn Gln Asp Val Lys Gln Val Glu His
1425                1430                1435                1440
Lys Pro Ser Gln Ser Tyr Leu Arg Val Arg Asn Lys Ser Asp Ile Ala
                1445                1450                1455    
Pro Ser Gln Gln Gln Val Ser Pro Gly Asp Met Asp Arg Thr Gln Ile
            1460                1465                1470        
Glu Leu Asn Pro Tyr Leu Thr Cys Val Phe Ser Gly Gly Lys Ala Val
        1475                1480                1485            
Pro Leu Ser Ala Ser Gln Met Pro Pro Ala Lys Met Ser Val Met Leu
    1490                1495                1500                
Pro Ser Val Asn Leu Glu Asp Cys Ser Gln Ser Leu Ser Leu Ser Thr
1505                1510                1515                1520
Met Gln Glu Asp Met Glu Ser Ser Gly Ala Asp Thr Phe
                1525                1530            


<210> 870
<211> 1533
<212> PRT
<213> Homo sapiens

<400> 870
Met Pro Val Lys Arg Leu Arg Glu Val Val Ser Gln Asn His Gly Asp
 1               5                  10                  15      
His Leu Val Leu Leu Lys Asp Glu Leu Pro Cys Val Pro Pro Ala Leu
            20                  25                  30          
Ser Ala Asn Lys Arg Leu Pro Val Gly Thr Gly Thr Ser Leu Asn Gly
        35                  40                  45              
Thr Ser Arg Gly Ser Ser Asp Leu Thr Ser Ala Arg Asn Cys Tyr Gln
    50                  55                  60                  
Pro Leu Leu Glu Asn Pro Met Val Ser Glu Ser Asp Phe Ser Lys Asp
65                  70                  75                  80  
Val Ala Val Gln Val Leu Pro Leu Asp Lys Ile Glu Glu Asn Asn Lys
                85                  90                  95      
Gln Lys Ala Asn Asp Ile Phe Ile Ser Gln Tyr Thr Met Gly Gln Lys
            100                 105                 110         
Asp Ala Leu Arg Thr Val Leu Lys Gln Lys Ala Gln Ser Met Pro Val
        115                 120                 125             
Phe Lys Glu Val Lys Val His Leu Leu Glu Asp Ala Gly Ile Glu Lys
    130                 135                 140                 
Asp Ala Val Thr Gln Glu Thr Arg Ile Ser Pro Ser Gly Ile Asp Ser
145                 150                 155                 160 
Ala Thr Thr Val Ala Ala Ala Thr Ala Ala Ala Ile Ala Thr Ala Ala
                165                 170                 175     
Pro Leu Ile Lys Val Gln Ser Asp Leu Glu Ala Lys Val Asn Ser Val
            180                 185                 190         
Thr Glu Leu Leu Ser Lys Leu Gln Glu Thr Asp Lys His Leu Gln Arg
        195                 200                 205             
Val Thr Glu Gln Gln Thr Ser Ile Gln Arg Lys Gln Glu Lys Leu His
    210                 215                 220                 
Cys His Asp His Glu Lys Gln Met Asn Val Phe Met Glu Gln His Ile
225                 230                 235                 240 
Arg His Leu Glu Lys Leu Gln Gln Gln Gln Ile Asp Ile Gln Thr His
                245                 250                 255     
Phe Ile Ser Ala Ala Leu Lys Thr Ser Ser Phe Gln Pro Val Ser Met
            260                 265                 270         
Pro Ser Ser Arg Ala Val Glu Lys Tyr Ser Val Lys Pro Glu His Pro
        275                 280                 285             
Asn Leu Gly Ser Cys Asn Pro Ser Leu Tyr Asn Thr Phe Ala Ser Lys
    290                 295                 300                 
Gln Ala Pro Leu Lys Glu Val Glu Asp Thr Ser Phe Asp Lys Gln Lys
305                 310                 315                 320 
Ser Pro Leu Glu Thr Pro Ala Pro Arg Arg Phe Ala Pro Val Pro Val
                325                 330                 335     
Ser Arg Asp Asp Glu Leu Ser Lys Arg Glu Asn Leu Leu Glu Glu Lys
            340                 345                 350         
Glu Asn Met Glu Val Ser Cys His Arg Gly Asn Val Arg Leu Leu Glu
        355                 360                 365             
Gln Ile Leu Asn Asn Asn Asp Ser Leu Thr Arg Lys Ser Glu Ser Ser
    370                 375                 380                 
Asn Thr Thr Ser Leu Thr Arg Ser Lys Ile Gly Trp Thr Pro Glu Lys
385                 390                 395                 400 
Thr Asn Arg Phe Pro Ser Cys Glu Glu Leu Glu Thr Thr Lys Val Thr
                405                 410                 415     
Met Gln Lys Ser Asp Asp Val Leu His Asp Leu Gly Gln Lys Glu Lys
            420                 425                 430         
Glu Thr Asn Ser Met Val Gln Pro Lys Glu Ser Leu Ser Met Leu Lys
        435                 440                 445             
Leu Pro Asp Leu Pro Gln Asn Ser Val Lys Leu Gln Thr Thr Asn Thr
    450                 455                 460                 
Thr Arg Ser Val Leu Lys Asp Ala Glu Lys Ile Leu Arg Gly Val Gln
465                 470                 475                 480 
Asn Asn Lys Lys Val Leu Glu Glu Asn Leu Glu Ala Ile Ile Arg Ala
                485                 490                 495     
Lys Asp Gly Ala Ala Met Tyr Ser Leu Ile Asn Ala Leu Ser Thr Asn
            500                 505                 510         
Arg Glu Met Ser Glu Lys Ile Arg Ile Arg Lys Thr Val Asp Glu Trp
        515                 520                 525             
Ile Lys Thr Ile Ser Ala Glu Ile Gln Asp Glu Leu Ser Arg Thr Asp
    530                 535                 540                 
Tyr Glu Gln Lys Arg Phe Asp Gln Lys Asn Gln Arg Thr Lys Lys Gly
545                 550                 555                 560 
Gln Asn Met Thr Lys Asp Ile Arg Thr Asn Thr Gln Asp Lys Thr Val
                565                 570                 575     
Asn Lys Ser Val Ile Pro Arg Lys His Ser Gln Lys Gln Ile Glu Glu
            580                 585                 590         
His Phe Arg Asn Leu Pro Met Arg Gly Met Pro Ala Ser Ser Leu Gln
        595                 600                 605             
Lys Glu Arg Lys Glu Gly Leu Leu Lys Ala Thr Thr Val Ile Gln Asp
    610                 615                 620                 
Glu Asp Tyr Met Leu Gln Val Tyr Gly Lys Pro Val Tyr Gln Gly His
625                 630                 635                 640 
Arg Ser Thr Leu Lys Lys Gly Pro Tyr Leu Arg Phe Asn Ser Pro Ser
                645                 650                 655     
Pro Lys Ser Arg Pro Gln Arg Pro Lys Val Ile Glu Arg Val Lys Gly
            660                 665                 670         
Thr Lys Val Lys Ser Ile Arg Thr Gln Thr Asp Phe Tyr Ala Thr Lys
        675                 680                 685             
Pro Lys Lys Met Asp Ser Lys Met Lys His Ser Val Pro Val Leu Pro
    690                 695                 700                 
His Gly Asp Gln Gln Tyr Leu Phe Ser Pro Ser Arg Glu Met Pro Thr
705                 710                 715                 720 
Phe Ser Gly Thr Leu Glu Gly His Leu Ile Pro Met Ala Ile Leu Leu
                725                 730                 735     
Gly Gln Thr Gln Ser Asn Ser Asp Thr Met Pro Pro Ala Gly Val Ile
            740                 745                 750         
Val Ser Lys Pro His Pro Val Thr Val Thr Thr Ser Ile Pro Pro Ser
        755                 760                 765             
Ser Arg Lys Val Glu Thr Gly Val Lys Lys Pro Asn Ile Ala Ile Val
    770                 775                 780                 
Glu Met Lys Ser Glu Lys Lys Asp Pro Pro Gln Leu Thr Val Gln Val
785                 790                 795                 800 
Leu Pro Ser Val Asp Ile Asp Ser Ile Ser Asn Ser Ser Ala Asp Val
                805                 810                 815     
Leu Ser Pro Leu Ser Ser Pro Lys Glu Ala Ser Pro Pro Pro Val Gln
            820                 825                 830         
Thr Trp Ile Lys Thr Pro Glu Ile Met Lys Val Asp Glu Glu Glu Val
        835                 840                 845             
Lys Phe Pro Gly Thr Asn Phe Asp Glu Ile Ile Asp Val Ile Gln Glu
    850                 855                 860                 
Glu Glu Lys Cys Asp Glu Ile Pro Asp Ser Glu Pro Ile Leu Glu Phe
865                 870                 875                 880 
Asn Arg Ser Val Lys Ala Asp Ser Thr Lys Tyr Asn Gly Pro Pro Phe
                885                 890                 895     
Pro Pro Val Ala Ser Thr Phe Gln Pro Thr Ala Asp Ile Leu Asp Lys
            900                 905                 910         
Val Ile Glu Arg Lys Glu Thr Leu Glu Asn Ser Leu Ile Gln Trp Val
        915                 920                 925             
Glu Gln Glu Ile Met Ser Arg Ile Ile Ser Gly Leu Phe Pro Val Gln
    930                 935                 940                 
Gln Gln Ile Ala Pro Ser Ile Ser Val Ser Val Ser Glu Thr Ser Glu
945                 950                 955                 960 
Pro Leu Thr Ser Asp Ile Val Glu Gly Thr Ser Ser Gly Ala Leu Gln
                965                 970                 975     
Leu Phe Val Asp Ala Gly Val Pro Val Asn Ser Asn Val Ile Lys His
            980                 985                 990         
Phe Val Asn Glu Ala Leu Ala Glu Thr Ile Ala Val Met Leu Gly Asp
        995                 1000                1005            
Arg Glu Ala Lys Lys Gln Gly Pro Val Ala Thr Gly Val Ser Gly Asp
    1010                1015                1020                
Ala Ser Thr Asn Glu Thr Tyr Leu Pro Ala Arg Val Cys Thr Pro Leu
1025                1030                1035                1040
Ala Thr Pro Gln Pro Thr Pro Pro Cys Ser Pro Ser Ser Pro Ala Lys
                1045                1050                1055    
Glu Cys Val Leu Val Lys Thr Pro Asp Ser Ser Pro Cys Asp Ser Asp
            1060                1065                1070        
His Asp Met Ala Phe Pro Val Lys Glu Ile Cys Ala Glu Lys Gly Asp
        1075                1080                1085            
Asp Met Pro Ala Ile Met Leu Val Asn Thr Pro Thr Val Thr Pro Thr
    1090                1095                1100                
Thr Thr Pro Pro Pro Ala Ala Ala Val Phe Thr Pro Thr Leu Ser Asp
1105                1110                1115                1120
Ile Ser Ile Asp Lys Leu Lys Val Ser Ser Pro Glu Leu Pro Lys Pro
                1125                1130                1135    
Trp Gly Asp Gly Asp Leu Pro Leu Glu Glu Glu Asn Pro Asn Ser Pro
            1140                1145                1150        
Gln Glu Glu Leu His Pro Arg Ala Ile Val Met Ser Val Ala Lys Asp
        1155                1160                1165            
Glu Glu Pro Glu Ser Met Asp Phe Pro Ala Gln Pro Pro Pro Pro Glu
    1170                1175                1180                
Pro Val Pro Phe Met Pro Phe Pro Ala Gly Thr Lys Ala Pro Ser Pro
1185                1190                1195                1200
Ser Gln Met Pro Gly Ser Asp Ser Ser Thr Leu Glu Ser Thr Leu Ser
                1205                1210                1215    
Val Thr Val Thr Glu Thr Glu Thr Leu Asp Lys Pro Ile Ser Glu Gly
            1220                1225                1230        
Glu Ile Leu Phe Ser Cys Gly Gln Lys Leu Ala Pro Lys Ile Leu Glu
        1235                1240                1245            
Asp Ile Gly Leu Tyr Leu Thr Asn Leu Asn Asp Ser Leu Ser Ser Thr
    1250                1255                1260                
Leu His Asp Ala Val Glu Met Glu Asp Asp Pro Pro Ser Glu Gly Gln
1265                1270                1275                1280
Val Ile Arg Met Ser His Lys Lys Phe His Ala Asp Ala Ile Leu Ser
                1285                1290                1295    
Phe Ala Lys Gln Asn Gln Glu Ser Ala Val Ser Gln Gln Ala Val Tyr
            1300                1305                1310        
His Ser Glu Asp Leu Glu Asn Ser Val Gly Glu Leu Ser Glu Gly Gln
        1315                1320                1325            
Arg Pro Gln Leu Thr Ala Ala Ala Glu Asn Ile Leu Met Gly His Ser
    1330                1335                1340                
Leu Tyr Met Gln Pro Pro Val Thr Asn Thr Gln Ser Leu Asp Gln Gln
1345                1350                1355                1360
Cys Asp Pro Lys Pro Leu Ser Arg Gln Phe Asp Thr Val Ser Gly Ser
                1365                1370                1375    
Ile Tyr Glu Asp Ser Cys Ala Ser His Gly Pro Met Ser Leu Gly Glu
            1380                1385                1390        
Leu Glu Leu Glu Pro Asn Ser Lys Leu Val Leu Pro Thr Thr Leu Leu
        1395                1400                1405            
Thr Ala Gln Glu Asn Asp Val Asn Leu Pro Val Ala Ala Glu Asp Phe
    1410                1415                1420                
Ser Gln Tyr Gln Leu Lys Gln Asn Gln Asp Val Lys Gln Val Glu His
1425                1430                1435                1440
Lys Pro Ser Gln Ser Tyr Leu Arg Val Arg Asn Lys Ser Asp Ile Ala
                1445                1450                1455    
Pro Ser Gln Gln Gln Val Ser Pro Gly Asp Met Asp Arg Thr Gln Ile
            1460                1465                1470        
Glu Leu Asn Pro Tyr Leu Thr Cys Val Phe Ser Gly Gly Lys Ala Val
        1475                1480                1485            
Pro Leu Ser Ala Ser Gln Met Pro Pro Ala Lys Met Ser Val Met Leu
    1490                1495                1500                
Pro Ser Val Asn Leu Glu Asp Cys Ser Gln Ser Leu Ser Leu Ser Thr
1505                1510                1515                1520
Met Gln Glu Asp Met Glu Ser Ser Gly Ala Asp Thr Phe
                1525                1530            


<210> 871
<211> 590
<212> PRT
<213> Homo sapiens

<400> 871
Met His Ser Met Ile Ser Ser Val Asp Val Lys Ser Glu Val Pro Val
 1               5                  10                  15      
Gly Leu Glu Pro Ile Ser Pro Leu Asp Leu Arg Thr Asp Leu Arg Met
            20                  25                  30          
Met Met Pro Val Val Asp Pro Val Val Arg Glu Lys Gln Leu Gln Gln
        35                  40                  45              
Glu Leu Leu Leu Ile Gln Gln Gln Gln Gln Ile Gln Lys Gln Leu Leu
    50                  55                  60                  
Ile Ala Glu Phe Gln Lys Gln His Glu Asn Leu Thr Arg Gln His Gln
65                  70                  75                  80  
Ala Gln Leu Gln Glu His Ile Lys Glu Leu Leu Ala Ile Lys Gln Gln
                85                  90                  95      
Gln Glu Leu Leu Glu Lys Glu Gln Lys Leu Glu Gln Gln Arg Gln Glu
            100                 105                 110         
Gln Glu Val Glu Arg His Arg Arg Glu Gln Gln Leu Pro Pro Leu Arg
        115                 120                 125             
Gly Lys Asp Arg Gly Arg Glu Arg Ala Val Ala Ser Thr Glu Val Lys
    130                 135                 140                 
Gln Lys Leu Gln Glu Phe Leu Leu Ser Lys Ser Ala Thr Lys Asp Thr
145                 150                 155                 160 
Pro Thr Asn Gly Lys Asn His Ser Val Ser Arg His Pro Lys Leu Trp
                165                 170                 175     
Tyr Thr Ala Ala His His Thr Ser Leu Asp Gln Ser Ser Pro Pro Leu
            180                 185                 190         
Ser Gly Thr Ser Pro Ser Tyr Lys Tyr Thr Leu Pro Gly Ala Gln Asp
        195                 200                 205             
Ala Lys Asp Asp Phe Pro Leu Arg Lys Thr Ala Ser Glu Pro Asn Leu
    210                 215                 220                 
Lys Val Arg Ser Arg Leu Lys Gln Lys Val Ala Glu Arg Arg Ser Ser
225                 230                 235                 240 
Pro Leu Leu Arg Arg Lys Asp Gly Asn Val Val Thr Ser Phe Lys Lys
                245                 250                 255     
Arg Met Phe Glu Val Thr Glu Ser Ser Val Ser Ser Ser Ser Pro Gly
            260                 265                 270         
Ser Gly Pro Ser Ser Pro Asn Asn Gly Pro Thr Gly Ser Val Thr Glu
        275                 280                 285             
Asn Glu Thr Ser Val Leu Pro Pro Thr Pro His Ala Glu Gln Met Val
    290                 295                 300                 
Ser Gln Gln Arg Ile Leu Ile His Glu Asp Ser Met Asn Leu Leu Ser
305                 310                 315                 320 
Leu Tyr Thr Ser Pro Ser Leu Pro Asn Ile Thr Leu Gly Leu Pro Ala
                325                 330                 335     
Val Pro Ser Gln Leu Asn Ala Ser Asn Ser Leu Lys Glu Lys Gln Lys
            340                 345                 350         
Cys Glu Thr Gln Thr Leu Arg Gln Gly Val Pro Leu Pro Gly Gln Tyr
        355                 360                 365             
Gly Gly Ser Ile Pro Ala Ser Ser Ser His Pro His Val Thr Leu Glu
    370                 375                 380                 
Gly Lys Pro Pro Asn Ser Ser His Gln Ala Leu Leu Gln His Leu Leu
385                 390                 395                 400 
Leu Lys Glu Gln Met Arg Gln Gln Lys Leu Leu Val Ala Gly Gly Val
                405                 410                 415     
Pro Leu His Pro Gln Ser Pro Leu Ala Thr Lys Glu Arg Ile Ser Pro
            420                 425                 430         
Gly Ile Arg Gly Thr His Lys Leu Pro Arg His Arg Pro Leu Asn Arg
        435                 440                 445             
Thr Gln Ser Ala Pro Leu Pro Gln Ser Thr Leu Ala Gln Leu Val Ile
    450                 455                 460                 
Gln Gln Gln His Gln Gln Phe Leu Glu Lys Gln Lys Gln Tyr Gln Gln
465                 470                 475                 480 
Gln Ile His Met Asn Lys Leu Leu Ser Lys Ser Ile Glu Gln Leu Lys
                485                 490                 495     
Gln Pro Gly Ser His Leu Glu Glu Ala Glu Glu Glu Leu Gln Gly Asp
            500                 505                 510         
Gln Ala Met Gln Glu Asp Arg Ala Pro Ser Ser Gly Asn Ser Thr Arg
        515                 520                 525             
Ser Asp Ser Ser Ala Cys Val Asp Asp Thr Leu Gly Gln Val Gly Ala
    530                 535                 540                 
Val Lys Val Lys Glu Glu Pro Val Asp Ser Asp Glu Asp Ala Gln Ile
545                 550                 555                 560 
Gln Glu Met Glu Ser Gly Glu Gln Ala Ala Phe Met Gln Gln Val Ile
                565                 570                 575     
Gly Lys Asp Leu Ala Pro Gly Phe Val Ile Lys Val Ile Ile
            580                 585                 590 


<210> 872
<211> 1124
<212> PRT
<213> Homo sapiens

<400> 872
Met Gly Glu Asn Glu Asp Glu Lys Gln Ala Gln Ala Gly Gln Val Phe
 1               5                  10                  15      
Glu Asn Phe Val Gln Ala Ser Thr Cys Lys Gly Thr Leu Gln Ala Phe
            20                  25                  30          
Asn Ile Leu Thr Arg His Leu Asp Leu Asp Pro Leu Asp His Arg Asn
        35                  40                  45              
Phe Tyr Ser Lys Leu Lys Ser Lys Val Thr Thr Trp Lys Ala Lys Ala
    50                  55                  60                  
Leu Trp Tyr Lys Leu Asp Lys Arg Gly Ser His Lys Glu Tyr Lys Arg
65                  70                  75                  80  
Gly Lys Ser Cys Thr Asn Thr Lys Cys Leu Ile Val Gly Gly Gly Pro
                85                  90                  95      
Cys Gly Leu Arg Thr Ala Ile Glu Leu Ala Tyr Leu Gly Ala Lys Val
            100                 105                 110         
Val Val Val Glu Lys Arg Asp Ser Phe Ser Arg Asn Asn Val Leu His
        115                 120                 125             
Leu Trp Pro Phe Thr Ile His Asp Leu Arg Gly Leu Gly Ala Lys Lys
    130                 135                 140                 
Phe Tyr Gly Lys Phe Cys Ala Gly Ser Ile Asp His Ile Ser Ile Arg
145                 150                 155                 160 
Gln Leu Gln Leu Ile Leu Phe Lys Val Ala Leu Met Leu Gly Val Glu
                165                 170                 175     
Ile His Val Asn Val Glu Phe Val Lys Val Leu Glu Pro Pro Glu Asp
            180                 185                 190         
Gln Glu Asn Gln Lys Ile Gly Trp Arg Ala Glu Phe Leu Pro Thr Asp
        195                 200                 205             
His Ser Leu Ser Glu Phe Glu Phe Asp Val Ile Ile Gly Ala Asp Gly
    210                 215                 220                 
Arg Arg Asn Thr Leu Glu Gly Phe Arg Arg Lys Glu Phe Arg Gly Lys
225                 230                 235                 240 
Leu Ala Ile Ala Ile Thr Ala Asn Phe Ile Asn Arg Asn Ser Thr Ala
                245                 250                 255     
Glu Ala Lys Val Glu Glu Ile Ser Gly Val Ala Phe Ile Phe Asn Gln
            260                 265                 270         
Lys Phe Phe Gln Asp Leu Lys Glu Glu Thr Gly Ile Asp Leu Glu Asn
        275                 280                 285             
Ile Val Tyr Tyr Lys Asp Cys Thr His Tyr Phe Val Met Thr Ala Lys
    290                 295                 300                 
Lys Gln Ser Leu Leu Asp Lys Gly Val Ile Ile Asn Asp Tyr Ile Asp
305                 310                 315                 320 
Thr Glu Met Leu Leu Cys Ala Glu Asn Val Asn Gln Asp Asn Leu Leu
                325                 330                 335     
Ser Tyr Ala Arg Glu Ala Ala Asp Phe Ala Thr Asn Tyr Gln Leu Pro
            340                 345                 350         
Ser Leu Asp Phe Ala Met Asn His Tyr Gly Gln Pro Asp Val Ala Met
        355                 360                 365             
Phe Asp Phe Thr Cys Met Tyr Ala Ser Glu Asn Ala Ala Leu Val Arg
    370                 375                 380                 
Glu Arg Gln Ala His Gln Leu Leu Val Ala Leu Val Gly Asp Ser Leu
385                 390                 395                 400 
Leu Glu Pro Phe Trp Pro Met Gly Thr Gly Cys Ala Arg Gly Phe Leu
                405                 410                 415     
Ala Ala Phe Asp Thr Ala Trp Met Val Lys Ser Trp Asn Gln Gly Thr
            420                 425                 430         
Pro Pro Leu Glu Leu Leu Ala Glu Arg Glu Ser Leu Tyr Arg Leu Leu
        435                 440                 445             
Pro Gln Thr Thr Pro Glu Asn Ile Asn Lys Asn Phe Glu Gln Tyr Thr
    450                 455                 460                 
Leu Asp Pro Gly Thr Arg Tyr Pro Asn Leu Asn Ser His Cys Val Arg
465                 470                 475                 480 
Pro His Gln Val Lys His Leu Tyr Ile Thr Lys Glu Leu Glu His Tyr
                485                 490                 495     
Pro Leu Glu Arg Leu Gly Ser Val Arg Arg Ser Val Asn Leu Ser Arg
            500                 505                 510         
Lys Glu Ser Asp Ile Arg Pro Ser Lys Leu Leu Thr Trp Cys Gln Gln
        515                 520                 525             
Gln Thr Glu Gly Tyr Gln His Val Asn Val Thr Asp Leu Thr Thr Ser
    530                 535                 540                 
Trp Arg Ser Gly Leu Ala Leu Cys Ala Ile Ile His Arg Phe Arg Pro
545                 550                 555                 560 
Glu Leu Ile Asn Phe Asp Ser Leu Asn Glu Asp Asp Ala Val Glu Asn
                565                 570                 575     
Asn Gln Leu Ala Phe Asp Val Ala Glu Arg Glu Phe Gly Ile Pro Pro
            580                 585                 590         
Val Thr Thr Gly Lys Glu Met Ala Ser Ala Gln Glu Pro Asp Lys Leu
        595                 600                 605             
Ser Met Val Met Tyr Leu Ser Lys Phe Tyr Glu Leu Phe Arg Gly Thr
    610                 615                 620                 
Pro Leu Arg Pro Val Asp Ser Trp Arg Lys Asn Tyr Gly Glu Asn Ala
625                 630                 635                 640 
Asp Leu Ser Leu Ala Lys Ser Ser Ile Ser Asn Asn Tyr Leu Asn Leu
                645                 650                 655     
Thr Phe Pro Arg Lys Arg Thr Pro Arg Val Asp Gly Gln Thr Gly Glu
            660                 665                 670         
Asn Asp Met Asn Lys Arg Arg Arg Lys Gly Phe Thr Asn Leu Asp Glu
        675                 680                 685             
Pro Ser Asn Phe Ser Ser Arg Ser Leu Gly Ser Asn Gln Glu Cys Gly
    690                 695                 700                 
Ser Ser Lys Glu Gly Gly Asn Gln Asn Lys Val Lys Ser Met Ala Asn
705                 710                 715                 720 
Gln Leu Leu Ala Lys Phe Glu Glu Ser Thr Arg Asn Pro Ser Leu Met
                725                 730                 735     
Lys Gln Glu Arg Arg Val Ser Gly Ile Gly Lys Pro Val Leu Cys Ser
            740                 745                 750         
Ser Ser Gly Pro Pro Val His Ser Cys Cys Pro Lys Pro Glu Glu Ala
        755                 760                 765             
Thr Pro Ser Pro Ser Pro Pro Leu Lys Arg Gln Phe Pro Ser Val Val
    770                 775                 780                 
Val Thr Gly His Val Leu Arg Glu Leu Lys Gln Val Ser Ala Gly Ser
785                 790                 795                 800 
Glu Cys Leu Ser Arg Pro Trp Arg Ala Arg Ala Lys Ser Asp Leu Gln
                805                 810                 815     
Leu Gly Gly Thr Glu Asn Phe Ala Thr Leu Pro Ser Thr Arg Pro Arg
            820                 825                 830         
Ala Gln Ala Leu Ser Gly Val Leu Trp Arg Leu Gln Gln Val Glu Glu
        835                 840                 845             
Lys Ile Leu Gln Lys Arg Ala Gln Asn Leu Ala Asn Arg Glu Phe His
    850                 855                 860                 
Thr Lys Asn Ile Lys Glu Lys Ala Ala His Leu Ala Ser Met Phe Gly
865                 870                 875                 880 
His Gly Asp Phe Pro Gln Asn Lys Leu Leu Ser Lys Gly Leu Ser His
                885                 890                 895     
Thr His Pro Pro Ser Pro Pro Ser Arg Leu Pro Ser Pro Asp Pro Ala
            900                 905                 910         
Ala Ser Ser Ser Pro Ser Thr Val Asp Ser Ala Ser Pro Ala Arg Lys
        915                 920                 925             
Glu Lys Lys Ser Pro Ser Gly Phe His Phe His Pro Ser His Leu Arg
    930                 935                 940                 
Thr Val His Pro Gln Leu Thr Val Gly Lys Val Ser Ser Gly Ile Gly
945                 950                 955                 960 
Ala Ala Ala Glu Val Leu Val Asn Leu Tyr Met Asn Asp His Arg Pro
                965                 970                 975     
Lys Ala Gln Ala Thr Ser Pro Asp Leu Glu Ser Met Arg Lys Ser Phe
            980                 985                 990         
Pro Leu Asn Leu Gly Gly Ser Asp Thr Cys Tyr Phe Cys Lys Lys Arg
        995                 1000                1005            
Val Tyr Val Met Glu Arg Leu Ser Ala Glu Gly His Phe Phe His Arg
    1010                1015                1020                
Glu Cys Phe Arg Cys Ser Ile Cys Ala Thr Thr Leu Arg Leu Ala Ala
1025                1030                1035                1040
Tyr Thr Phe Asp Cys Asp Glu Gly Lys Phe Tyr Cys Lys Pro His Phe
                1045                1050                1055    
Ile His Cys Lys Thr Asn Ser Lys Gln Arg Lys Arg Arg Ala Glu Leu
            1060                1065                1070        
Lys Gln Gln Arg Glu Glu Glu Ala Thr Trp Gln Glu Gln Glu Ala Pro
        1075                1080                1085            
Arg Arg Asp Thr Pro Thr Glu Ser Ser Cys Ala Val Ala Ala Ile Gly
    1090                1095                1100                
Thr Leu Glu Gly Ser Pro Pro Val His Phe Ser Leu Pro Val Leu His
1105                1110                1115                1120
Pro Leu Leu Gly
                


<210> 873
<211> 652
<212> PRT
<213> Homo sapiens

<400> 873
Met Ile Asn Ala Gln Glu Leu Leu Thr Leu Glu Asp Val Thr Val Glu
 1               5                  10                  15      
Phe Thr Trp Glu Glu Trp Gln Leu Leu Gly Pro Phe Gln Lys Asp Leu
            20                  25                  30          
Tyr Arg Asp Val Met Leu Glu Ile Tyr Ser Asn Leu Leu Ser Met Gly
        35                  40                  45              
Tyr Gln Val Ser Lys Pro Asp Ala Leu Ser Lys Leu Glu Arg Gly Glu
    50                  55                  60                  
Glu Pro Trp Thr Met Glu Asp Glu Arg His Ser Arg Ile Cys Pro Glu
65                  70                  75                  80  
Asn Asn Glu Val Asp Asp His Leu Gln Asp His Leu Glu Asn Gln Arg
                85                  90                  95      
Met Leu Lys Ser Val Glu Gln Tyr His Glu His Asn Ala Phe Gly Asn
            100                 105                 110         
Thr Ala Ser Gln Thr Lys Ser Leu Cys Leu Phe Arg Glu Asn His Asp
        115                 120                 125             
Thr Phe Glu Leu Tyr Ile Lys Thr Leu Lys Ser Asn Leu Ser Leu Val
    130                 135                 140                 
Asn Gln Asn Lys Ser Cys Glu Ile Asn Asn Ser Thr Lys Phe Ser Gly
145                 150                 155                 160 
Asp Gly Lys Ser Phe Leu His Gly Asn Tyr Glu Glu Leu Tyr Ser Ala
                165                 170                 175     
Ala Lys Phe Ser Val Ser Thr Lys Ala Asn Ser Thr Lys Ser Gln Val
            180                 185                 190         
Ser Lys His Gln Arg Thr His Glu Ile Glu Lys Asn His Val Cys Ser
        195                 200                 205             
Glu Cys Gly Lys Ala Phe Val Lys Lys Ser Gln Leu Thr Asp His Glu
    210                 215                 220                 
Arg Val His Thr Gly Glu Lys Pro Tyr Gly Cys Thr Leu Cys Ala Lys
225                 230                 235                 240 
Val Phe Ser Arg Lys Ser Arg Leu Asn Glu His Gln Arg Ile His Lys
                245                 250                 255     
Arg Glu Lys Ser Phe Ile Cys Ser Glu Cys Gly Lys Val Phe Thr Met
            260                 265                 270         
Lys Ser Arg Leu Ile Glu His Gln Arg Thr His Thr Gly Glu Lys Pro
        275                 280                 285             
Tyr Ile Cys Asn Glu Cys Gly Lys Gly Phe Pro Gly Lys Arg Asn Leu
    290                 295                 300                 
Ile Val His Gln Arg Asn His Thr Gly Glu Lys Ser Tyr Ile Cys Ser
305                 310                 315                 320 
Glu Cys Gly Lys Gly Phe Thr Gly Lys Ser Met Leu Ile Ile His Gln
                325                 330                 335     
Arg Thr His Thr Gly Glu Lys Pro Tyr Ile Cys Ser Glu Cys Gly Lys
            340                 345                 350         
Gly Phe Thr Thr Lys His Tyr Val Ile Ile His Gln Arg Asn His Thr
        355                 360                 365             
Gly Glu Lys Pro Tyr Ile Cys Asn Glu Cys Gly Lys Gly Phe Thr Met
    370                 375                 380                 
Lys Ser Arg Met Ile Glu His Gln Arg Thr His Thr Gly Glu Lys Pro
385                 390                 395                 400 
Tyr Ile Cys Ser Glu Cys Gly Lys Gly Phe Pro Arg Lys Ser Asn Leu
                405                 410                 415     
Ile Val His Gln Arg Asn His Thr Val Glu Lys Ser Tyr Leu Cys Ser
            420                 425                 430         
Glu Cys Gly Lys Gly Phe Thr Val Lys Ser Met Leu Ile Ile His Gln
        435                 440                 445             
Arg Thr His Thr Gly Glu Lys Pro Tyr Thr Cys Ser Glu Cys Gly Lys
    450                 455                 460                 
Gly Phe Pro Leu Lys Ser Arg Leu Ile Val His Gln Arg Thr His Thr
465                 470                 475                 480 
Gly Glu Lys Pro Tyr Arg Cys Ser Glu Cys Gly Lys Gly Phe Ile Val
                485                 490                 495     
Asn Ser Gly Leu Met Leu His Gln Arg Thr His Thr Gly Glu Lys Pro
            500                 505                 510         
Tyr Ile Cys Asn Glu Cys Gly Lys Gly Phe Ala Phe Lys Ser Asn Leu
        515                 520                 525             
Val Val His Gln Arg Thr His Thr Gly Glu Lys Pro Phe Met Cys Ser
    530                 535                 540                 
Glu Cys Gly Lys Gly Phe Thr Met Lys Arg Tyr Leu Ile Val His Gln
545                 550                 555                 560 
Gln Ile His Thr Glu Glu Lys Ser Cys Ile Cys Ser Glu Cys Gly Arg
                565                 570                 575     
Gly Phe Ala Lys Glu Thr Glu Leu Ala Leu His Lys Gln Val His Thr
            580                 585                 590         
Gly Glu Lys Pro Tyr Gly Cys Asn Glu Cys Gly Lys Gly Phe Thr Met
        595                 600                 605             
Lys Ser Arg Leu Ile Val His Gln Arg Thr His Thr Gly Glu Lys Pro
    610                 615                 620                 
Phe Val Cys Ser Glu Cys Arg Lys Ala Phe Ser Ser Lys Arg Asn Leu
625                 630                 635                 640 
Ile Val His Gln Arg Thr His Asn Gly Asn Lys Pro
                645                 650         


<210> 874
<211> 1186
<212> PRT
<213> Homo sapiens

<400> 874
Met Ser Lys Leu Lys Val Ile Pro Glu Lys Ser Leu Thr Asn Asn Ser
 1               5                  10                  15      
Arg Ile Val Gly Leu Leu Ala Gln Leu Glu Lys Ile Asn Ala Glu Pro
            20                  25                  30          
Ser Glu Ser Asp Thr Ala Arg Tyr Val Thr Ser Lys Ile Leu His Leu
        35                  40                  45              
Ala Gln Ser Gln Glu Lys Thr Arg Arg Glu Met Thr Ala Lys Gly Ser
    50                  55                  60                  
Thr Gly Met Glu Ile Leu Leu Ser Thr Leu Glu Asn Thr Lys Asp Leu
65                  70                  75                  80  
Gln Thr Thr Leu Asn Ile Leu Ser Ile Leu Val Glu Leu Val Ser Ala
                85                  90                  95      
Gly Gly Gly Arg Arg Val Ser Phe Leu Val Thr Lys Gly Gly Ser Gln
            100                 105                 110         
Ile Leu Leu Gln Leu Leu Met Asn Ala Ser Lys Glu Ser Pro Pro His
        115                 120                 125             
Glu Asp Leu Met Val Gln Ile His Ser Ile Leu Ala Lys Ile Gly Pro
    130                 135                 140                 
Lys Asp Lys Lys Phe Gly Val Lys Ala Arg Ile Asn Gly Ala Leu Asn
145                 150                 155                 160 
Ile Thr Leu Asn Leu Val Lys Gln Asn Leu Gln Asn His Arg Leu Val
                165                 170                 175     
Leu Pro Cys Leu Gln Leu Leu Arg Val Tyr Ser Ala Asn Ser Val Asn
            180                 185                 190         
Ser Val Ser Leu Gly Lys Asn Gly Val Val Glu Leu Met Phe Lys Ile
        195                 200                 205             
Ile Gly Pro Phe Ser Lys Lys Asn Ser Ser Leu Ile Lys Val Ala Leu
    210                 215                 220                 
Asp Thr Leu Ala Ala Leu Leu Lys Ser Lys Thr Asn Ala Arg Arg Ala
225                 230                 235                 240 
Val Asp Arg Gly Tyr Val Gln Val Leu Leu Thr Ile Tyr Val Asp Trp
                245                 250                 255     
His Arg His Asp Asn Arg His Arg Asn Met Leu Ile Arg Lys Gly Ile
            260                 265                 270         
Leu Arg Ser Leu Lys Ser Val Thr Asn Ile Lys Leu Gly Arg Lys Ala
        275                 280                 285             
Phe Ile Asp Ala Asn Gly Met Lys Ile Leu Tyr Asn Thr Ser Gln Leu
    290                 295                 300                 
Pro Val Ile Pro Val Thr Gly Pro Val Ala Gln Leu Tyr Ser Leu Pro
305                 310                 315                 320 
Pro Glu Val Asp Asp Val Val Asp Glu Ser Asp Asp Asn Asp Asp Ile
                325                 330                 335     
Asp Val Glu Ala Glu Asn Glu Thr Glu Asn Glu Asp Asp Leu Asp Gln
            340                 345                 350         
Asn Phe Lys Asn Asp Asp Ile Glu Thr Asp Ile Asn Lys Leu Lys Pro
        355                 360                 365             
Gln Gln Glu Pro Gly Arg Thr Ile Glu Asp Leu Lys Met Tyr Glu His
    370                 375                 380                 
Leu Phe Pro Glu Leu Val Asp Asp Phe Gln Asp Tyr Asp Leu Ile Ser
385                 390                 395                 400 
Lys Glu Pro Lys Pro Phe Val Phe Glu Gly Lys Val Arg Gly Pro Ile
                405                 410                 415     
Val Val Pro Thr Ala Gly Glu Gly Thr Ser Gly Asn Ser Gly Asn Leu
            420                 425                 430         
Arg Lys Val Val Met Lys Glu Asn Ile Ser Ser Lys Gly Asp Glu Gly
        435                 440                 445             
Glu Lys Lys Ser Thr Phe Met Asp Leu Ala Lys Glu Asp Ile Lys Asp
    450                 455                 460                 
Asn Asp Arg Thr Leu Gln Gln Gln Pro Gly Asp Gln Asn Arg Thr Ile
465                 470                 475                 480 
Ser Ser Val His Gly Leu Asn Asn Asp Ile Val Lys Ala Leu Asp Arg
                485                 490                 495     
Ile Thr Leu Gln Asn Ile Pro Ser Gln Thr Ala Pro Gly Phe Thr Ala
            500                 505                 510         
Glu Met Lys Lys Asp Cys Ser Leu Pro Leu Thr Val Leu Thr Cys Ala
        515                 520                 525             
Lys Ala Cys Pro His Met Ala Thr Cys Gly Asn Val Leu Phe Glu Gly
    530                 535                 540                 
Arg Thr Val Gln Leu Gly Lys Leu Cys Cys Thr Gly Val Gly Thr Glu
545                 550                 555                 560 
Asp Asp Glu Asp Thr Glu Ser Asn Ser Ser Val Glu Gln Ala Ser Val
                565                 570                 575     
Glu Val Pro Asp Gly Pro Thr Leu His Asp Pro Asp Leu Tyr Ile Glu
            580                 585                 590         
Ile Val Lys Asn Thr Lys Ser Val Pro Glu Tyr Ser Glu Val Ala Tyr
        595                 600                 605             
Pro Asp Tyr Phe Gly His Ile Pro Pro Pro Phe Lys Glu Pro Ile Leu
    610                 615                 620                 
Glu Arg Pro Tyr Gly Val Gln Arg Thr Lys Ile Ala Gln Asp Ile Glu
625                 630                 635                 640 
Arg Leu Ile His Gln Ser Asp Ile Ile Asp Arg Val Val Tyr Asp Leu
                645                 650                 655     
Asp Asn Pro Asn Tyr Thr Ile Pro Glu Glu Gly Asp Ile Leu Lys Phe
            660                 665                 670         
Asn Ser Lys Phe Glu Ser Gly Asn Leu Arg Lys Val Ile Gln Ile Arg
        675                 680                 685             
Lys Asn Glu Tyr Asp Leu Ile Leu Asn Ser Asp Ile Asn Ser Asn His
    690                 695                 700                 
Tyr His Gln Trp Phe Tyr Phe Glu Val Ser Gly Met Arg Pro Gly Val
705                 710                 715                 720 
Ala Tyr Arg Phe Asn Ile Ile Asn Cys Glu Lys Ser Asn Ser Gln Phe
                725                 730                 735     
Asn Tyr Gly Met Gln Pro Leu Met Tyr Ser Val Gln Glu Ala Leu Asn
            740                 745                 750         
Ala Arg Pro Trp Trp Ile Arg Met Gly Thr Asp Ile Cys Tyr Tyr Lys
        755                 760                 765             
Asn His Phe Ser Arg Ser Ser Val Ala Ala Gly Gly Gln Lys Gly Lys
    770                 775                 780                 
Ser Tyr Tyr Thr Ile Thr Phe Thr Val Asn Phe Pro His Lys Asp Asp
785                 790                 795                 800 
Val Cys Tyr Phe Ala Tyr His Tyr Pro Tyr Thr Tyr Ser Thr Leu Gln
                805                 810                 815     
Met His Leu Gln Lys Leu Glu Ser Ala His Asn Pro Gln Gln Ile Tyr
            820                 825                 830         
Phe Arg Lys Asp Val Leu Cys Glu Thr Leu Ser Gly Asn Ser Cys Pro
        835                 840                 845             
Leu Val Thr Ile Thr Ala Met Pro Glu Ser Asn Tyr Tyr Glu His Ile
    850                 855                 860                 
Cys His Phe Arg Asn Arg Pro Tyr Val Phe Leu Ser Ala Arg Val His
865                 870                 875                 880 
Pro Gly Glu Thr Asn Ala Ser Trp Val Met Lys Gly Thr Leu Glu Tyr
                885                 890                 895     
Leu Met Ser Asn Asn Pro Thr Ala Gln Ser Leu Arg Glu Ser Tyr Ile
            900                 905                 910         
Phe Lys Ile Val Pro Met Leu Asn Pro Asp Gly Val Ile Asn Gly Asn
        915                 920                 925             
His Arg Cys Ser Leu Ser Gly Glu Asp Leu Asn Arg Gln Trp Gln Ser
    930                 935                 940                 
Pro Ser Pro Asp Leu His Pro Thr Ile Tyr His Ala Lys Gly Leu Leu
945                 950                 955                 960 
Gln Tyr Leu Ala Ala Val Lys Arg Leu Pro Leu Val Tyr Cys Asp Tyr
                965                 970                 975     
His Gly His Ser Arg Lys Lys Asn Val Phe Met Tyr Gly Cys Ser Ile
            980                 985                 990         
Lys Glu Thr Val Trp His Thr Asn Asp Asn Ala Thr Ser Cys Asp Val
        995                 1000                1005            
Val Glu Asp Thr Gly Tyr Arg Thr Leu Pro Lys Ile Leu Ser His Ile
    1010                1015                1020                
Ala Pro Ala Phe Cys Met Ser Ser Cys Ser Phe Val Val Glu Lys Ser
1025                1030                1035                1040
Lys Glu Ser Thr Ala Arg Val Val Val Trp Arg Glu Ile Gly Val Gln
                1045                1050                1055    
Arg Ser Tyr Thr Met Glu Ser Thr Leu Cys Gly Cys Asp Gln Gly Lys
            1060                1065                1070        
Tyr Lys Gly Leu Gln Ile Gly Thr Arg Glu Leu Glu Glu Met Gly Ala
        1075                1080                1085            
Lys Phe Cys Val Gly Leu Leu Arg Leu Lys Arg Leu Thr Ser Pro Leu
    1090                1095                1100                
Glu Tyr Asn Leu Pro Ser Ser Leu Leu Asp Phe Glu Asn Asp Leu Ile
1105                1110                1115                1120
Glu Ser Ser Cys Lys Val Thr Ser Pro Thr Thr Tyr Val Leu Asp Glu
                1125                1130                1135    
Asp Glu Pro Arg Phe Leu Glu Glu Val Asp Tyr Ser Ala Glu Ser Asn
            1140                1145                1150        
Asp Glu Leu Asp Ile Glu Leu Ala Glu Asn Val Gly Asp Tyr Glu Pro
        1155                1160                1165            
Ser Ala Gln Glu Glu Val Leu Ser Asp Ser Glu Leu Ser Arg Thr Tyr
    1170                1175                1180                
Leu Pro
1185    


<210> 875
<211> 823
<212> PRT
<213> Homo sapiens

<400> 875
Met Ala Leu Pro Arg Cys Thr Trp Pro Asn Tyr Val Trp Arg Ala Val
 1               5                  10                  15      
Met Ala Cys Leu Val His Arg Gly Leu Gly Ala Pro Leu Thr Leu Cys
            20                  25                  30          
Met Leu Gly Cys Leu Leu Gln Ala Gly His Val Leu Ser Gln Lys Leu
        35                  40                  45              
Asp Asp Val Asp Pro Leu Val Ala Thr Asn Phe Gly Lys Ile Arg Gly
    50                  55                  60                  
Ile Lys Lys Glu Leu Asn Asn Glu Ile Leu Gly Pro Val Ile Gln Phe
65                  70                  75                  80  
Leu Gly Val Pro Tyr Ala Ala Pro Pro Thr Gly Glu Arg Arg Phe Gln
                85                  90                  95      
Pro Pro Glu Pro Pro Ser Pro Trp Ser Asp Ile Arg Asn Ala Thr Gln
            100                 105                 110         
Phe Ala Pro Val Cys Pro Gln Asn Ile Ile Asp Gly Arg Leu Pro Glu
        115                 120                 125             
Val Met Leu Pro Val Trp Phe Thr Asn Asn Leu Asp Val Val Ser Ser
    130                 135                 140                 
Tyr Val Gln Asp Gln Ser Glu Asp Cys Leu Tyr Leu Asn Ile Tyr Val
145                 150                 155                 160 
Pro Thr Glu Asp Asp Ile Arg Asp Ser Gly Gly Pro Lys Pro Val Met
                165                 170                 175     
Val Tyr Ile His Gly Gly Ser Tyr Met Glu Gly Thr Gly Asn Leu Tyr
            180                 185                 190         
Asp Gly Ser Val Leu Ala Ser Tyr Gly Asn Val Ile Val Ile Thr Val
        195                 200                 205             
Asn Tyr Arg Leu Gly Val Leu Gly Phe Leu Ser Thr Gly Asp Gln Ala
    210                 215                 220                 
Ala Lys Gly Asn Tyr Gly Leu Leu Asp Leu Ile Gln Ala Leu Arg Trp
225                 230                 235                 240 
Thr Ser Glu Asn Ile Gly Phe Phe Gly Gly Asp Pro Leu Arg Ile Thr
                245                 250                 255     
Val Phe Gly Ser Gly Ala Gly Gly Ser Cys Val Asn Leu Leu Thr Leu
            260                 265                 270         
Ser His Tyr Ser Glu Gly Asn Arg Trp Ser Asn Ser Thr Lys Gly Leu
        275                 280                 285             
Phe Gln Arg Ala Ile Ala Gln Ser Gly Thr Ala Leu Ser Ser Trp Ala
    290                 295                 300                 
Val Ser Phe Gln Pro Ala Lys Tyr Ala Arg Met Leu Ala Thr Lys Val
305                 310                 315                 320 
Gly Cys Asn Val Ser Asp Thr Val Glu Leu Val Glu Cys Leu Gln Lys
                325                 330                 335     
Lys Pro Tyr Lys Glu Leu Val Asp Gln Asp Ile Gln Pro Ala Arg Tyr
            340                 345                 350         
His Ile Ala Phe Gly Pro Val Ile Asp Gly Asp Val Ile Pro Asp Asp
        355                 360                 365             
Pro Gln Ile Leu Met Glu Gln Gly Glu Phe Leu Asn Tyr Asp Ile Met
    370                 375                 380                 
Leu Gly Val Asn Gln Gly Glu Gly Leu Lys Phe Val Glu Asn Ile Val
385                 390                 395                 400 
Asp Ser Asp Asp Gly Ile Ser Ala Ser Asp Phe Asp Phe Ala Val Ser
                405                 410                 415     
Asn Phe Val Asp Asn Leu Tyr Gly Tyr Pro Glu Gly Lys Asp Val Leu
            420                 425                 430         
Arg Glu Thr Ile Lys Phe Met Tyr Thr Asp Trp Ala Asp Arg His Asn
        435                 440                 445             
Pro Glu Thr Arg Arg Lys Thr Leu Leu Ala Leu Phe Thr Asp His Gln
    450                 455                 460                 
Trp Val Ala Pro Ala Val Ala Thr Ala Asp Leu His Ser Asn Phe Gly
465                 470                 475                 480 
Ser Pro Thr Tyr Phe Tyr Ala Phe Tyr His His Cys Gln Thr Asp Gln
                485                 490                 495     
Val Pro Ala Trp Ala Asp Ala Ala His Gly Asp Glu Val Pro Tyr Val
            500                 505                 510         
Leu Gly Ile Pro Met Ile Gly Pro Thr Glu Leu Phe Pro Cys Asn Phe
        515                 520                 525             
Ser Lys Asn Asp Val Met Leu Ser Ala Val Val Met Thr Tyr Trp Thr
    530                 535                 540                 
Asn Phe Ala Lys Thr Gly Asp Pro Asn Gln Pro Val Pro Gln Asp Thr
545                 550                 555                 560 
Lys Phe Ile His Thr Lys Pro Asn Arg Phe Glu Glu Val Ala Trp Thr
                565                 570                 575     
Arg Tyr Ser Gln Lys Asp Gln Leu Tyr Leu His Ile Gly Leu Lys Pro
            580                 585                 590         
Arg Val Lys Glu His Tyr Arg Ala Asn Lys Val Asn Leu Trp Leu Glu
        595                 600                 605             
Leu Val Pro His Leu His Asn Leu Asn Asp Ile Ser Gln Tyr Thr Ser
    610                 615                 620                 
Thr Thr Thr Lys Val Pro Ser Thr Asp Ile Thr Phe Arg Pro Thr Arg
625                 630                 635                 640 
Lys Asn Ser Val Pro Val Thr Ser Ala Phe Pro Thr Ala Lys Gln Asp
                645                 650                 655     
Asp Pro Lys Gln Gln Pro Ser Pro Phe Ser Val Asp Gln Arg Asp Tyr
            660                 665                 670         
Ser Thr Glu Leu Ser Val Thr Ile Ala Val Gly Ala Ser Leu Leu Phe
        675                 680                 685             
Leu Asn Ile Leu Ala Phe Ala Ala Leu Tyr Tyr Lys Lys Asp Lys Arg
    690                 695                 700                 
Arg His Asp Val His Arg Arg Cys Ser Pro Gln Arg Thr Thr Thr Asn
705                 710                 715                 720 
Asp Leu Thr His Ala Gln Glu Glu Glu Ile Met Ser Leu Gln Met Lys
                725                 730                 735     
His Thr Asp Leu Asp His Glu Cys Glu Ser Ile His Pro His Glu Val
            740                 745                 750         
Val Leu Arg Thr Ala Cys Pro Pro Asp Tyr Thr Leu Ala Met Arg Arg
        755                 760                 765             
Ser Pro Asp Asp Val Pro Leu Met Thr Pro Asn Thr Ile Thr Met Ile
    770                 775                 780                 
Pro Asn Thr Ile Pro Gly Ile Gln Pro Leu His Thr Phe Asn Thr Phe
785                 790                 795                 800 
Thr Gly Gly Gln Asn Asn Thr Leu Pro His Pro His Pro His Pro His
                805                 810                 815     
Ser His Ser Thr Thr Arg Val
            820             


<210> 876
<211> 764
<212> PRT
<213> Homo sapiens

<400> 876
Met Glu Glu Ser Ser Ser Val Ala Met Leu Val Pro Asp Ile Gly Glu
 1               5                  10                  15      
Gln Glu Ala Ile Leu Thr Ala Glu Ser Ile Ile Ser Pro Ser Leu Glu
            20                  25                  30          
Ile Asp Glu Gln Arg Lys Thr Lys Pro Asp Pro Leu Ile His Val Ile
        35                  40                  45              
Gln Lys Leu Ser Lys Ile Val Glu Asn Glu Lys Ser Gln Lys Cys Leu
    50                  55                  60                  
Leu Ile Gly Lys Lys Arg Pro Arg Ser Ser Ala Ala Thr His Ser Leu
65                  70                  75                  80  
Glu Thr Gln Glu Leu Cys Glu Ile Pro Ala Lys Val Ile Gln Ser Pro
                85                  90                  95      
Ala Ala Asp Thr Arg Arg Ala Glu Met Ser Gln Thr Asn Phe Thr Pro
            100                 105                 110         
Asp Thr Leu Ala Gln Asn Glu Gly Lys Ala Met Ser Tyr Gln Cys Ser
        115                 120                 125             
Leu Cys Lys Phe Leu Ser Ser Ser Phe Ser Val Leu Lys Asp His Ile
    130                 135                 140                 
Lys Gln His Gly Gln Gln Asn Glu Val Ile Leu Met Cys Ser Glu Cys
145                 150                 155                 160 
His Ile Thr Ser Arg Ser Gln Glu Glu Leu Glu Ala His Val Val Asn
                165                 170                 175     
Asp His Asp Asn Asp Ala Asn Ile His Thr Gln Ser Lys Ala Gln Gln
            180                 185                 190         
Cys Val Ser Pro Ser Ser Ser Leu Cys Arg Lys Thr Thr Glu Arg Asn
        195                 200                 205             
Glu Thr Ile Pro Asp Ile Pro Val Ser Val Asp Asn Leu Gln Thr His
    210                 215                 220                 
Thr Val Gln Thr Ala Ser Val Ala Glu Met Gly Arg Arg Lys Trp Tyr
225                 230                 235                 240 
Ala Tyr Glu Gln Tyr Gly Met Tyr Arg Cys Leu Phe Cys Ser Tyr Thr
                245                 250                 255     
Cys Gly Gln Gln Arg Met Leu Lys Thr His Ala Trp Lys His Ala Gly
            260                 265                 270         
Glu Val Asp Cys Ser Tyr Pro Ile Phe Glu Asn Glu Asn Glu Pro Leu
        275                 280                 285             
Gly Leu Leu Asp Ser Ser Ala Ala Ala Ala Pro Gly Gly Val Asp Ala
    290                 295                 300                 
Val Val Ile Ala Ile Gly Glu Ser Glu Leu Ser Ile His Asn Gly Pro
305                 310                 315                 320 
Ser Val Gln Val Gln Ile Cys Ser Ser Glu Gln Leu Ser Ser Ser Ser
                325                 330                 335     
Pro Leu Glu Gln Ser Ala Glu Arg Gly Val His Leu Ser Gln Ser Val
            340                 345                 350         
Thr Leu Asp Pro Asn Glu Glu Glu Met Leu Glu Val Ile Ser Asp Ala
        355                 360                 365             
Glu Glu Asn Leu Ile Pro Asp Ser Leu Leu Thr Ser Ala Gln Lys Ile
    370                 375                 380                 
Ile Ser Ser Ser Pro Asn Lys Lys Gly His Val Asn Val Ile Val Glu
385                 390                 395                 400 
Arg Leu Pro Ser Ala Glu Glu Thr Leu Ser Gln Lys Arg Phe Leu Met
                405                 410                 415     
Asn Thr Glu Met Glu Glu Gly Lys Asp Leu Ser Leu Thr Glu Ala Gln
            420                 425                 430         
Ile Gly Arg Glu Gly Met Asp Asp Val Tyr Arg Ala Asp Lys Cys Thr
        435                 440                 445             
Val Asp Ile Gly Gly Leu Ile Ile Gly Trp Ser Ser Ser Glu Lys Lys
    450                 455                 460                 
Asp Glu Leu Met Asn Lys Gly Leu Ala Thr Asp Glu Asn Ala Pro Pro
465                 470                 475                 480 
Gly Arg Arg Arg Thr Asn Ser Glu Ser Leu Arg Leu His Ser Leu Ala
                485                 490                 495     
Ala Glu Ala Leu Val Thr Met Pro Ile Arg Ala Ala Glu Leu Thr Arg
            500                 505                 510         
Ala Asn Leu Gly His Tyr Gly Asp Ile Asn Leu Leu Asp Pro Asp Thr
        515                 520                 525             
Ser Gln Arg Gln Val Asp Ser Thr Leu Ala Ala Tyr Ser Lys Met Met
    530                 535                 540                 
Ser Pro Leu Lys Asn Ser Ser Asp Gly Leu Thr Ser Leu Asn Gln Ser
545                 550                 555                 560 
Asn Ser Thr Leu Val Ala Leu Pro Glu Gly Arg Gln Glu Leu Ser Asp
                565                 570                 575     
Gly Gln Val Lys Thr Gly Ile Ser Met Ser Leu Leu Thr Val Ile Glu
            580                 585                 590         
Lys Leu Arg Glu Arg Thr Asp Gln Asn Ala Ser Asp Asp Asp Ile Leu
        595                 600                 605             
Lys Glu Leu Gln Asp Asn Ala Gln Cys Gln Pro Asn Ser Asp Thr Ser
    610                 615                 620                 
Leu Ser Gly Asn Asn Val Val Glu Tyr Ile Pro Asn Ala Glu Arg Pro
625                 630                 635                 640 
Tyr Arg Cys Arg Leu Cys His Tyr Thr Ser Gly Asn Lys Gly Tyr Ile
                645                 650                 655     
Lys Gln His Leu Arg Val His Arg Gln Arg Gln Pro Tyr Gln Cys Pro
            660                 665                 670         
Ile Cys Glu His Ile Ala Asp Asn Ser Lys Asp Leu Glu Ser His Met
        675                 680                 685             
Ile His His Cys Lys Thr Arg Ile Tyr Gln Cys Lys Gln Cys Glu Glu
    690                 695                 700                 
Ser Phe His Tyr Lys Ser Gln Leu Arg Asn His Glu Arg Glu Gln His
705                 710                 715                 720 
Ser Leu Pro Asp Thr Leu Ser Ile Ala Thr Ser Asn Glu Pro Arg Ile
                725                 730                 735     
Ser Ser Asp Thr Ala Asp Gly Lys Cys Val Gln Glu Gly Ile Tyr Val
            740                 745                 750         
Phe Cys Tyr Ala Gly Cys Ser Asp Leu His Met Thr
        755                 760                 


<210> 877
<211> 99
<212> PRT
<213> Homo sapiens

<400> 877
Met Asp Leu Ile Gly Phe Gly Tyr Ala Ala Leu Val Thr Phe Gly Ser
 1               5                  10                  15      
Ile Phe Gly Tyr Lys Arg Arg Gly Gly Val Pro Ser Leu Ile Ala Gly
            20                  25                  30          
Leu Phe Val Gly Cys Leu Ala Gly Tyr Gly Ala Tyr Arg Val Ser Asn
        35                  40                  45              
Asp Lys Arg Asp Val Lys Val Ser Leu Phe Thr Ala Phe Phe Leu Ala
    50                  55                  60                  
Thr Ile Met Gly Val Arg Phe Lys Arg Ser Lys Lys Ile Met Pro Ala
65                  70                  75                  80  
Gly Leu Val Ala Gly Leu Ser Leu Met Met Ile Leu Arg Leu Val Leu
                85                  90                  95      
Leu Leu Leu
            


<210> 878
<211> 258
<212> PRT
<213> Homo sapiens

<400> 878
Met Ala Ala Ser Val Leu Asn Thr Val Leu Arg Arg Leu Pro Met Leu
 1               5                  10                  15      
Ser Leu Phe Arg Gly Ser His Arg Val Gln Val Pro Leu Gln Thr Leu
            20                  25                  30          
Cys Thr Lys Ala Pro Ser Glu Glu Asp Ser Leu Ser Ser Val Pro Ile
        35                  40                  45              
Ser Pro Tyr Lys Asp Glu Pro Trp Lys Tyr Leu Glu Ser Glu Glu Tyr
    50                  55                  60                  
Gln Glu Arg Tyr Gly Ser Arg Pro Val Trp Ala Asp Tyr Arg Arg Asn
65                  70                  75                  80  
His Lys Gly Gly Val Pro Pro Gln Arg Thr Arg Lys Thr Cys Ile Arg
                85                  90                  95      
Arg Asn Lys Val Val Gly Asn Pro Cys Pro Ile Cys Arg Asp His Lys
            100                 105                 110         
Leu His Val Asp Phe Arg Asn Val Lys Leu Leu Glu Gln Phe Val Cys
        115                 120                 125             
Ala His Thr Gly Ile Ile Phe Tyr Ala Pro Tyr Thr Gly Val Cys Val
    130                 135                 140                 
Lys Gln His Lys Arg Leu Thr Gln Ala Ile Gln Lys Ala Arg Asp His
145                 150                 155                 160 
Gly Leu Leu Ile Tyr His Ile Pro Gln Val Glu Pro Arg Asp Leu Asp
                165                 170                 175     
Phe Ser Thr Ser His Gly Ala Val Ser Ala Thr Pro Pro Ala Pro Thr
            180                 185                 190         
Leu Val Ser Gly Asp Pro Trp Tyr Pro Trp Tyr Asn Trp Lys Gln Pro
        195                 200                 205             
Pro Glu Arg Glu Leu Ser Arg Leu Arg Arg Leu Tyr Gln Gly His Leu
    210                 215                 220                 
Gln Glu Glu Ser Gly Pro Pro Pro Glu Ser Met Pro Lys Met Pro Pro
225                 230                 235                 240 
Arg Thr Pro Ala Glu Ala Ser Ser Thr Gly Gln Thr Gly Pro Gln Ser
                245                 250                 255     
Ala Leu
        


<210> 879
<211> 608
<212> PRT
<213> Homo sapiens

<400> 879
Met Ala Ala Ser Lys Pro Val Glu Ala Ala Val Val Ala Ala Ala Val
 1               5                  10                  15      
Pro Ser Ser Gly Ser Gly Val Gly Gly Gly Gly Thr Ala Gly Pro Gly
            20                  25                  30          
Thr Gly Gly Leu Pro Arg Trp Gln Leu Ala Leu Ala Val Gly Ala Pro
        35                  40                  45              
Leu Leu Leu Gly Ala Gly Ala Ile Tyr Leu Trp Ser Arg Gln Gln Arg
    50                  55                  60                  
Arg Arg Glu Ala Arg Gly Arg Gly Asp Ala Ser Gly Leu Lys Arg Asn
65                  70                  75                  80  
Ser Glu Arg Lys Thr Pro Glu Gly Arg Ala Ser Pro Ala Pro Gly Ser
                85                  90                  95      
Gly His Pro Glu Gly Pro Gly Ala His Leu Asp Met Asn Ser Leu Asp
            100                 105                 110         
Arg Ala Gln Ala Ala Lys Asn Lys Gly Asn Lys Tyr Phe Lys Ala Gly
        115                 120                 125             
Lys Tyr Glu Gln Ala Ile Gln Cys Tyr Thr Glu Ala Ile Ser Leu Cys
    130                 135                 140                 
Pro Thr Glu Lys Asn Val Asp Leu Ser Thr Phe Tyr Gln Asn Arg Ala
145                 150                 155                 160 
Ala Ala Phe Glu Gln Leu Gln Lys Trp Lys Glu Val Ala Gln Asp Cys
                165                 170                 175     
Thr Lys Ala Val Glu Leu Asn Pro Lys Tyr Val Lys Ala Leu Phe Arg
            180                 185                 190         
Arg Ala Lys Ala His Glu Lys Leu Asp Asn Lys Lys Glu Cys Leu Glu
        195                 200                 205             
Asp Val Thr Ala Val Cys Ile Leu Glu Gly Phe Gln Asn Gln Gln Ser
    210                 215                 220                 
Met Leu Leu Ala Asp Lys Val Leu Lys Leu Leu Gly Lys Glu Lys Ala
225                 230                 235                 240 
Lys Glu Lys Tyr Lys Asn Arg Glu Pro Leu Met Pro Ser Pro Gln Phe
                245                 250                 255     
Ile Lys Ser Tyr Phe Ser Ser Phe Thr Asp Asp Ile Ile Ser Gln Pro
            260                 265                 270         
Met Leu Lys Gly Glu Lys Ser Asp Glu Asp Lys Asp Lys Glu Gly Glu
        275                 280                 285             
Ala Leu Glu Val Lys Glu Asn Ser Gly Tyr Leu Lys Ala Lys Gln Tyr
    290                 295                 300                 
Met Glu Glu Glu Asn Tyr Asp Lys Ile Ile Ser Glu Cys Ser Lys Glu
305                 310                 315                 320 
Ile Asp Ala Glu Gly Lys Tyr Met Ala Glu Ala Leu Leu Leu Arg Ala
                325                 330                 335     
Thr Phe Tyr Leu Leu Ile Gly Asn Ala Asn Ala Ala Lys Pro Asp Leu
            340                 345                 350         
Asp Lys Val Ile Ser Leu Lys Glu Ala Asn Val Lys Leu Arg Ala Asn
        355                 360                 365             
Ala Leu Ile Lys Arg Gly Ser Met Tyr Met Gln Gln Gln Gln Pro Leu
    370                 375                 380                 
Leu Ser Thr Gln Asp Phe Asn Met Ala Ala Asp Ile Asp Pro Gln Asn
385                 390                 395                 400 
Ala Asp Val Tyr His His Arg Gly Gln Leu Lys Ile Leu Leu Asp Gln
                405                 410                 415     
Val Glu Glu Ala Val Ala Asp Phe Asp Glu Cys Ile Arg Leu Arg Pro
            420                 425                 430         
Glu Ser Ala Leu Ala Gln Ala Gln Lys Cys Phe Ala Leu Tyr Arg Gln
        435                 440                 445             
Ala Tyr Thr Gly Asn Asn Ser Ser Gln Ile Gln Ala Ala Met Lys Gly
    450                 455                 460                 
Phe Glu Glu Val Ile Lys Lys Phe Pro Arg Cys Ala Glu Gly Tyr Ala
465                 470                 475                 480 
Leu Tyr Ala Gln Ala Leu Thr Asp Gln Gln Gln Phe Gly Lys Ala Asp
                485                 490                 495     
Glu Met Tyr Asp Lys Cys Ile Asp Leu Glu Pro Asp Asn Ala Thr Thr
            500                 505                 510         
Tyr Val His Lys Gly Leu Leu Gln Leu Gln Trp Lys Gln Asp Leu Asp
        515                 520                 525             
Arg Gly Leu Glu Leu Ile Ser Lys Ala Ile Glu Ile Asp Asn Lys Cys
    530                 535                 540                 
Asp Phe Ala Tyr Glu Thr Met Gly Thr Ile Glu Val Gln Arg Gly Asn
545                 550                 555                 560 
Met Glu Lys Ala Ile Asp Met Phe Asn Lys Ala Ile Asn Leu Ala Lys
                565                 570                 575     
Ser Glu Met Glu Met Ala His Leu Tyr Ser Leu Cys Asp Ala Ala His
            580                 585                 590         
Ala Gln Thr Glu Val Ala Lys Lys Tyr Gly Leu Lys Pro Pro Thr Leu
        595                 600                 605             


<210> 880
<211> 608
<212> PRT
<213> Homo sapiens

<400> 880
Met Ala Ala Ser Lys Pro Val Glu Ala Ala Val Val Ala Ala Ala Val
 1               5                  10                  15      
Pro Ser Ser Gly Ser Gly Val Gly Gly Gly Gly Thr Ala Gly Pro Gly
            20                  25                  30          
Thr Gly Gly Leu Pro Arg Trp Gln Leu Ala Leu Ala Val Gly Ala Pro
        35                  40                  45              
Leu Leu Leu Gly Ala Gly Ala Ile Tyr Leu Trp Ser Arg Gln Gln Arg
    50                  55                  60                  
Arg Arg Glu Ala Arg Gly Arg Gly Asp Ala Ser Gly Leu Lys Arg Asn
65                  70                  75                  80  
Ser Glu Arg Lys Thr Pro Glu Gly Arg Ala Ser Pro Ala Pro Gly Ser
                85                  90                  95      
Gly His Pro Glu Gly Pro Gly Ala His Leu Asp Met Asn Ser Leu Asp
            100                 105                 110         
Arg Ala Gln Ala Ala Lys Asn Lys Gly Asn Lys Tyr Phe Lys Ala Gly
        115                 120                 125             
Lys Tyr Glu Gln Ala Ile Gln Cys Tyr Thr Glu Ala Ile Ser Leu Cys
    130                 135                 140                 
Pro Thr Glu Lys Asn Val Asp Leu Ser Thr Phe Tyr Gln Asn Arg Ala
145                 150                 155                 160 
Ala Ala Phe Glu Gln Leu Gln Lys Trp Lys Glu Val Ala Gln Asp Cys
                165                 170                 175     
Thr Lys Ala Val Glu Leu Asn Pro Lys Tyr Val Lys Ala Leu Phe Arg
            180                 185                 190         
Arg Ala Lys Ala His Glu Lys Leu Asp Asn Lys Lys Glu Cys Leu Glu
        195                 200                 205             
Asp Val Thr Ala Val Cys Ile Leu Glu Gly Phe Gln Asn Gln Gln Ser
    210                 215                 220                 
Met Leu Leu Ala Asp Lys Val Leu Lys Leu Leu Gly Lys Glu Lys Ala
225                 230                 235                 240 
Lys Glu Lys Tyr Lys Asn Arg Glu Pro Leu Met Pro Ser Pro Gln Phe
                245                 250                 255     
Ile Lys Ser Tyr Phe Ser Ser Phe Thr Asp Asp Ile Ile Ser Gln Pro
            260                 265                 270         
Met Leu Lys Gly Glu Lys Ser Asp Glu Asp Lys Asp Lys Glu Gly Glu
        275                 280                 285             
Ala Leu Glu Val Lys Glu Asn Ser Gly Tyr Leu Lys Ala Lys Gln Tyr
    290                 295                 300                 
Met Glu Glu Glu Asn Tyr Asp Lys Ile Ile Ser Glu Cys Ser Lys Glu
305                 310                 315                 320 
Ile Asp Ala Glu Gly Lys Tyr Met Ala Glu Ala Leu Leu Leu Arg Ala
                325                 330                 335     
Thr Phe Tyr Leu Leu Ile Gly Asn Ala Asn Ala Ala Lys Pro Asp Leu
            340                 345                 350         
Asp Lys Val Ile Ser Leu Lys Glu Ala Asn Val Lys Leu Arg Ala Asn
        355                 360                 365             
Ala Leu Ile Lys Arg Gly Ser Met Tyr Met Gln Gln Gln Gln Pro Leu
    370                 375                 380                 
Leu Ser Thr Gln Asp Phe Asn Met Ala Ala Asp Ile Asp Pro Gln Asn
385                 390                 395                 400 
Ala Asp Val Tyr His His Arg Gly Gln Leu Lys Ile Leu Leu Asp Gln
                405                 410                 415     
Val Glu Glu Ala Val Ala Asp Phe Asp Glu Cys Ile Arg Leu Arg Pro
            420                 425                 430         
Glu Ser Ala Leu Ala Gln Ala Gln Lys Cys Phe Ala Leu Tyr Arg Gln
        435                 440                 445             
Ala Tyr Thr Gly Asn Asn Ser Ser Gln Ile Gln Ala Ala Met Lys Gly
    450                 455                 460                 
Phe Glu Glu Val Ile Lys Lys Phe Pro Arg Cys Ala Glu Gly Tyr Ala
465                 470                 475                 480 
Leu Tyr Ala Gln Ala Leu Thr Asp Gln Gln Gln Phe Gly Lys Ala Asp
                485                 490                 495     
Glu Met Tyr Asp Lys Cys Ile Asp Leu Glu Pro Asp Asn Ala Thr Thr
            500                 505                 510         
Tyr Val His Lys Gly Leu Leu Gln Leu Gln Trp Lys Gln Asp Leu Asp
        515                 520                 525             
Arg Gly Leu Glu Leu Ile Ser Lys Ala Ile Glu Ile Asp Asn Lys Cys
    530                 535                 540                 
Asp Phe Ala Tyr Glu Thr Met Gly Thr Ile Glu Val Gln Arg Gly Asn
545                 550                 555                 560 
Met Glu Lys Ala Ile Asp Met Phe Asn Lys Ala Ile Asn Leu Ala Lys
                565                 570                 575     
Ser Glu Met Glu Met Ala His Leu Tyr Ser Leu Cys Asp Ala Ala His
            580                 585                 590         
Ala Gln Thr Glu Val Ala Lys Lys Tyr Gly Leu Lys Pro Pro Thr Leu
        595                 600                 605             


<210> 881
<211> 741
<212> PRT
<213> Homo sapiens

<400> 881
Met Asp Ile Glu Asp Glu Glu Asn Met Ser Ser Ser Ser Thr Asp Val
 1               5                  10                  15      
Lys Glu Asn Arg Asn Leu Asp Asn Val Ser Pro Lys Asp Gly Ser Thr
            20                  25                  30          
Pro Gly Pro Gly Glu Gly Ser Gln Leu Ser Asn Gly Gly Gly Gly Gly
        35                  40                  45              
Pro Gly Arg Lys Arg Pro Leu Glu Glu Gly Ser Asn Gly His Ser Lys
    50                  55                  60                  
Tyr Arg Leu Lys Lys Arg Arg Lys Thr Pro Gly Pro Val Leu Pro Lys
65                  70                  75                  80  
Asn Ala Leu Met Gln Leu Asn Glu Ile Lys Pro Gly Leu Gln Tyr Thr
                85                  90                  95      
Leu Leu Ser Gln Thr Gly Pro Val His Ala Pro Leu Phe Val Met Ser
            100                 105                 110         
Val Glu Val Asn Gly Gln Val Phe Glu Gly Ser Gly Pro Thr Lys Lys
        115                 120                 125             
Lys Ala Lys Leu His Ala Ala Glu Lys Ala Leu Arg Ser Phe Val Gln
    130                 135                 140                 
Phe Pro Asn Ala Ser Glu Ala His Leu Ala Met Gly Arg Thr Leu Ser
145                 150                 155                 160 
Val Asn Thr Asp Phe Thr Ser Asp Gln Ala Asp Phe Pro Asp Thr Leu
                165                 170                 175     
Phe Asn Gly Phe Glu Thr Pro Asp Lys Ala Glu Pro Pro Phe Tyr Val
            180                 185                 190         
Gly Ser Asn Gly Asp Asp Ser Phe Ser Ser Ser Gly Asp Leu Ser Leu
        195                 200                 205             
Ser Ala Ser Pro Val Pro Ala Ser Leu Ala Gln Pro Pro Leu Pro Val
    210                 215                 220                 
Leu Pro Pro Phe Pro Pro Pro Ser Gly Lys Asn Pro Val Met Ile Leu
225                 230                 235                 240 
Asn Glu Leu Arg Pro Gly Leu Lys Tyr Asp Phe Leu Ser Glu Ser Gly
                245                 250                 255     
Glu Ser His Ala Lys Ser Phe Val Met Ser Val Val Val Asp Gly Gln
            260                 265                 270         
Phe Phe Glu Gly Ser Gly Arg Asn Lys Lys Leu Ala Lys Ala Arg Ala
        275                 280                 285             
Ala Gln Ser Ala Leu Ala Ala Ile Phe Asn Leu His Leu Asp Gln Thr
    290                 295                 300                 
Pro Ser Arg Gln Pro Ile Pro Ser Glu Gly Leu Gln Leu His Leu Pro
305                 310                 315                 320 
Gln Val Leu Ala Asp Ala Val Ser Arg Leu Val Leu Gly Lys Phe Gly
                325                 330                 335     
Asp Leu Thr Asp Asn Phe Ser Ser Pro His Ala Arg Arg Lys Val Leu
            340                 345                 350         
Ala Gly Val Val Met Thr Thr Gly Thr Asp Val Lys Asp Ala Lys Val
        355                 360                 365             
Ile Ser Val Ser Thr Gly Thr Lys Cys Ile Asn Gly Glu Tyr Met Ser
    370                 375                 380                 
Asp Arg Gly Leu Ala Leu Asn Asp Cys His Ala Glu Ile Ile Ser Arg
385                 390                 395                 400 
Arg Ser Leu Leu Arg Phe Leu Tyr Thr Gln Leu Glu Leu Tyr Leu Asn
                405                 410                 415     
Asn Lys Asp Asp Gln Lys Arg Ser Ile Phe Gln Lys Ser Glu Arg Gly
            420                 425                 430         
Gly Phe Arg Leu Lys Glu Asn Val Gln Phe His Leu Tyr Ile Ser Thr
        435                 440                 445             
Ser Pro Cys Gly Asp Ala Arg Ile Phe Ser Pro His Glu Pro Ile Leu
    450                 455                 460                 
Glu Gly Ser Arg Ser Tyr Thr Gln Ala Gly Val Gln Trp Cys Asn His
465                 470                 475                 480 
Gly Ser Leu Gln Pro Arg Pro Pro Gly Leu Leu Ser Asp Pro Ser Thr
                485                 490                 495     
Ser Thr Phe Gln Gly Ala Gly Thr Thr Glu Pro Ala Asp Arg His Pro
            500                 505                 510         
Asn Arg Lys Ala Arg Gly Gln Leu Arg Thr Lys Ile Glu Ser Gly Glu
        515                 520                 525             
Gly Thr Ile Pro Val Arg Ser Asn Ala Ser Ile Gln Thr Trp Asp Gly
    530                 535                 540                 
Val Leu Gln Gly Glu Arg Leu Leu Thr Met Ser Cys Ser Asp Lys Ile
545                 550                 555                 560 
Ala Arg Trp Asn Val Val Gly Ile Gln Gly Ser Leu Leu Ser Ile Phe
                565                 570                 575     
Val Glu Pro Ile Tyr Phe Ser Ser Ile Ile Leu Gly Ser Leu Tyr His
            580                 585                 590         
Gly Asp His Leu Ser Arg Ala Met Tyr Gln Arg Ile Ser Asn Ile Glu
        595                 600                 605             
Asp Leu Pro Pro Leu Tyr Thr Leu Asn Lys Pro Leu Leu Ser Gly Ile
    610                 615                 620                 
Ser Asn Ala Glu Ala Arg Gln Pro Gly Lys Ala Pro Asn Phe Ser Val
625                 630                 635                 640 
Asn Trp Thr Val Gly Asp Ser Ala Ile Glu Val Ile Asn Ala Thr Thr
                645                 650                 655     
Gly Lys Asp Glu Leu Gly Arg Ala Ser Arg Leu Cys Lys His Ala Leu
            660                 665                 670         
Tyr Cys Arg Trp Met Arg Val His Gly Lys Val Pro Ser His Leu Leu
        675                 680                 685             
Arg Ser Lys Ile Thr Lys Pro Asn Val Tyr His Glu Ser Lys Leu Ala
    690                 695                 700                 
Ala Lys Glu Tyr Gln Ala Ala Lys Ala Arg Leu Phe Thr Ala Phe Ile
705                 710                 715                 720 
Lys Ala Gly Leu Gly Ala Trp Val Glu Lys Pro Thr Glu Gln Asp Gln
                725                 730                 735     
Phe Ser Leu Thr Pro
            740     


<210> 882
<211> 335
<212> PRT
<213> Homo sapiens

<400> 882
Met Gly Lys Val Lys Val Gly Val Asn Gly Phe Gly Arg Ile Gly Arg
 1               5                  10                  15      
Leu Val Thr Arg Ala Ala Phe Asn Ser Gly Lys Val Asp Ile Val Ala
            20                  25                  30          
Ile Asn Asp Pro Phe Ile Asp Leu Asn Tyr Met Val Tyr Met Phe Gln
        35                  40                  45              
Tyr Asp Ser Thr His Gly Lys Phe His Gly Thr Val Lys Ala Glu Asn
    50                  55                  60                  
Gly Lys Leu Val Ile Asn Gly Asn Pro Ile Thr Ile Phe Gln Glu Arg
65                  70                  75                  80  
Asp Pro Ser Lys Ile Lys Trp Gly Asp Ala Gly Ala Glu Tyr Val Val
                85                  90                  95      
Glu Ser Thr Gly Val Phe Thr Thr Met Glu Lys Ala Gly Ala His Leu
            100                 105                 110         
Gln Gly Gly Ala Lys Arg Val Ile Ile Ser Ala Pro Ser Ala Asp Ala
        115                 120                 125             
Pro Met Phe Val Met Gly Val Asn His Glu Lys Tyr Asp Asn Ser Leu
    130                 135                 140                 
Lys Ile Ile Ser Asn Ala Ser Cys Thr Thr Asn Cys Leu Ala Pro Leu
145                 150                 155                 160 
Ala Lys Val Ile His Asp Asn Phe Gly Ile Val Glu Gly Leu Met Thr
                165                 170                 175     
Thr Val His Ala Ile Thr Ala Thr Gln Lys Thr Val Asp Gly Pro Ser
            180                 185                 190         
Gly Lys Leu Trp Arg Asp Gly Arg Gly Ala Leu Gln Asn Ile Ile Pro
        195                 200                 205             
Ala Ser Thr Gly Ala Ala Lys Ala Val Gly Lys Val Ile Pro Glu Leu
    210                 215                 220                 
Asn Gly Lys Leu Thr Gly Met Ala Phe Arg Val Pro Thr Ala Asn Val
225                 230                 235                 240 
Ser Val Val Asp Leu Thr Cys Arg Leu Glu Lys Pro Ala Lys Tyr Asp
                245                 250                 255     
Asp Ile Lys Lys Val Val Lys Gln Ala Ser Glu Gly Pro Leu Lys Gly
            260                 265                 270         
Ile Leu Gly Tyr Thr Glu His Gln Val Val Ser Ser Asp Phe Asn Ser
        275                 280                 285             
Asp Thr His Ser Ser Thr Phe Asp Ala Gly Ala Gly Ile Ala Leu Asn
    290                 295                 300                 
Asp His Phe Val Lys Leu Ile Ser Trp Tyr Asp Asn Glu Phe Gly Tyr
305                 310                 315                 320 
Ser Asn Arg Val Val Asp Leu Met Ala His Met Ala Ser Lys Glu
                325                 330                 335 


<210> 883
<211> 462
<212> PRT
<213> Homo sapiens

<400> 883
Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys
 1               5                  10                  15      
Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser
            20                  25                  30          
Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala
        35                  40                  45              
Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser
    50                  55                  60                  
Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys
65                  70                  75                  80  
Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu
                85                  90                  95      
Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys
            100                 105                 110         
Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr
        115                 120                 125             
Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu
    130                 135                 140                 
Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr
145                 150                 155                 160 
Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr
                165                 170                 175     
Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn
            180                 185                 190         
Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr
        195                 200                 205             
Leu Cys Lys Cys Gln Pro Gly Phe Thr Gly Ala Arg Cys Thr Glu Asn
    210                 215                 220                 
Val Pro Met Lys Val Gln Asn Gln Glu Lys Ala Glu Glu Leu Tyr Gln
225                 230                 235                 240 
Lys Arg Val Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val
                245                 250                 255     
Gly Ile Met Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys
            260                 265                 270         
Lys Leu His Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn
        275                 280                 285             
Met Met Asn Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu
    290                 295                 300                 
Asn Val Gln Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser
305                 310                 315                 320 
Glu His Ile Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His
                325                 330                 335     
Tyr Thr Ser Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser
            340                 345                 350         
His Ser Trp Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His
        355                 360                 365             
Ser Val Ile Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro
    370                 375                 380                 
Thr Gly Gly Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu
385                 390                 395                 400 
Cys Asn Ser Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg
                405                 410                 415     
Asp Ser Pro His Ser Glu Arg His Asn Leu Ile Ala Glu Leu Arg Arg
            420                 425                 430         
Asn Lys Ala His Arg Ser Lys Cys Met Gln Ile Gln Leu Ser Ala Thr
        435                 440                 445             
His Leu Arg Ser Ser Ser Ile Pro His Leu Gly Phe Ile Leu
    450                 455                 460         


<210> 884
<211> 452
<212> PRT
<213> Homo sapiens

<400> 884
Met Ala Ala Gly Glu Pro Arg Ser Leu Leu Phe Phe Gln Lys Pro Val
 1               5                  10                  15      
Thr Phe Glu Asp Val Ala Val Asn Phe Thr Gln Glu Glu Trp Asp Cys
            20                  25                  30          
Leu Asp Ala Ser Gln Arg Val Leu Tyr Gln Asp Val Met Ser Glu Thr
        35                  40                  45              
Phe Lys Asn Leu Thr Ser Val Ala Arg Ile Phe Leu His Lys Pro Glu
    50                  55                  60                  
Leu Ile Thr Lys Leu Glu Gln Glu Glu Glu Gln Trp Arg Glu Thr Arg
65                  70                  75                  80  
Val Leu Gln Ala Ser Gln Ala Gly Pro Pro Phe Phe Cys Tyr Thr Cys
                85                  90                  95      
Gly Lys Cys Phe Ser Arg Arg Ser Tyr Leu Tyr Ser His Gln Phe Val
            100                 105                 110         
His Asn Pro Lys Leu Thr Asn Ser Cys Ser Gln Cys Gly Lys Leu Phe
        115                 120                 125             
Arg Ser Pro Lys Ser Leu Ser Tyr His Arg Arg Met His Leu Gly Glu
    130                 135                 140                 
Arg Pro Phe Cys Cys Thr Leu Cys Asp Lys Thr Tyr Cys Asp Ala Ser
145                 150                 155                 160 
Gly Leu Ser Arg His Arg Arg Val His Leu Gly Tyr Arg Pro His Ser
                165                 170                 175     
Cys Ser Val Cys Gly Lys Ser Phe Arg Asp Gln Ser Glu Leu Lys Arg
            180                 185                 190         
His Gln Lys Ile His Gln Asn Gln Glu Pro Val Asp Gly Asn Gln Glu
        195                 200                 205             
Cys Thr Leu Arg Ile Pro Gly Thr Gln Ala Glu Phe Gln Thr Pro Ile
    210                 215                 220                 
Ala Arg Ser Gln Arg Ser Ile Gln Gly Leu Leu Asp Val Asn His Ala
225                 230                 235                 240 
Pro Val Ala Arg Ser Gln Glu Pro Ile Phe Arg Thr Glu Gly Pro Met
                245                 250                 255     
Ala Gln Asn Gln Ala Ser Val Leu Lys Asn Gln Ala Pro Val Thr Arg
            260                 265                 270         
Thr Gln Ala Pro Ile Thr Gly Thr Leu Cys Gln Val Ala Arg Ser Asn
        275                 280                 285             
Ser His Pro Val Lys Pro Ser Arg Leu Asn Val Phe Cys Cys Pro His
    290                 295                 300                 
Cys Ser Leu Thr Phe Ser Lys Lys Ser Tyr Leu Ser Arg His Gln Lys
305                 310                 315                 320 
Ala His Leu Thr Glu Pro Pro Asn Tyr Cys Phe His Cys Ser Lys Ser
                325                 330                 335     
Phe Ser Ser Phe Ser Arg Leu Val Arg His Gln Gln Thr His Trp Lys
            340                 345                 350         
Gln Lys Ser Tyr Leu Cys Pro Ile Cys Asp Leu Ser Phe Gly Glu Lys
        355                 360                 365             
Glu Gly Leu Met Asp His Trp Arg Gly Tyr Lys Gly Lys Asp Leu Cys
    370                 375                 380                 
Gln Ser Ser His His Lys Cys Arg Val Ile Leu Gly Gln Trp Leu Gly
385                 390                 395                 400 
Phe Ser His Asp Val Pro Thr Met Ala Gly Glu Glu Trp Lys His Gly
                405                 410                 415     
Gly Asp Gln Ser Pro Pro Arg Ile His Thr Pro Arg Arg Arg Gly Leu
            420                 425                 430         
Arg Glu Lys Ala Cys Lys Gly Asp Lys Thr Lys Glu Ala Val Ser Ile
        435                 440                 445             
Leu Lys His Lys
    450         


<210> 885
<211> 278
<212> PRT
<213> Homo sapiens

<400> 885
Asp Glu Tyr Leu Gly Ser Leu Gly Leu Phe Arg Lys Leu Thr Ala Lys
 1               5                  10                  15      
Asp Ala Ser Cys Leu Phe Arg Ala Ile Ser Glu Gln Leu Phe Cys Ser
            20                  25                  30          
Gln Val His His Leu Glu Ile Arg Lys Ala Cys Val Ser Tyr Met Arg
        35                  40                  45              
Glu Asn Gln Gln Thr Phe Glu Ser Tyr Val Glu Gly Ser Phe Glu Lys
    50                  55                  60                  
Tyr Leu Glu Arg Leu Gly Asp Pro Lys Glu Ser Ala Gly Gln Leu Glu
65                  70                  75                  80  
Ile Arg Ala Leu Ser Leu Ile Tyr Asn Arg Asp Phe Ile Leu Tyr Arg
                85                  90                  95      
Phe Pro Gly Lys Pro Pro Thr Tyr Val Thr Asp Asn Gly Tyr Glu Asp
            100                 105                 110         
Lys Ile Leu Leu Cys Tyr Ser Ser Ser Gly His Tyr Asp Ser Val Tyr
        115                 120                 125             
Ser Lys Gln Phe Gln Ser Ser Ala Ala Val Cys Gln Ala Val Leu Tyr
    130                 135                 140                 
Glu Ile Leu Tyr Lys Asp Val Phe Val Val Asp Glu Glu Glu Leu Lys
145                 150                 155                 160 
Thr Ala Ile Lys Leu Phe Arg Ser Gly Ser Lys Lys Asn Arg Asn Asn
                165                 170                 175     
Ala Val Thr Gly Ser Glu Asp Ala His Thr Asp Tyr Lys Ser Ser Asn
            180                 185                 190         
Gln Asn Arg Met Glu Glu Trp Gly Ala Cys Tyr Asn Ala Glu Asn Ile
        195                 200                 205             
Pro Glu Gly Tyr Asn Lys Gly Thr Glu Glu Thr Lys Ser Pro Glu Asn
    210                 215                 220                 
Pro Ser Lys Met Pro Phe Pro Tyr Lys Val Leu Lys Ala Leu Asp Pro
225                 230                 235                 240 
Glu Ile Tyr Arg Asn Val Glu Phe Asp Val Trp Leu Asp Ser Arg Lys
                245                 250                 255     
Glu Leu Gln Lys Ser Asp Tyr Met Glu Tyr Ala Gly Arg Gln Tyr Tyr
            260                 265                 270         
Leu Gly Asp Lys Cys Gln
        275             


<210> 886
<211> 373
<212> PRT
<213> Homo sapiens

<400> 886
Met Ala Glu Gln Thr Asp Ser Asp Ser Asp Ser Glu Gly Gly Ala Ala
 1               5                  10                  15      
Gly Gly Glu Ala Asp Met Asp Phe Leu Arg Asn Leu Phe Ser Gln Thr
            20                  25                  30          
Leu Ser Leu Gly Ser Gln Lys Glu Arg Leu Leu Asp Glu Leu Thr Leu
        35                  40                  45              
Glu Gly Val Ala Arg Tyr Met Gln Ser Glu Arg Cys Arg Arg Val Ile
    50                  55                  60                  
Cys Leu Val Gly Ala Gly Ile Ser Thr Ser Ala Gly Ile Pro Asp Phe
65                  70                  75                  80  
Arg Ser Pro Ser Thr Gly Leu Tyr Asp Asn Leu Glu Lys Tyr His Leu
                85                  90                  95      
Pro Tyr Pro Glu Ala Ile Phe Glu Ile Ser Tyr Phe Lys Lys His Pro
            100                 105                 110         
Glu Pro Phe Phe Ala Leu Ala Lys Glu Leu Tyr Pro Gly Gln Phe Gln
        115                 120                 125             
Ala Asn His Leu Ser Leu Leu His Ala Pro Ala Glu Gly Gln Gly Ala
    130                 135                 140                 
Thr Pro Ala Leu Leu His Ala Glu His Arg Tyr Pro Gly Ala Asn Ser
145                 150                 155                 160 
Arg Ala Gly Thr Gly Gly Leu Gly Gly Gly Ala Arg His Leu Leu His
                165                 170                 175     
Ile Thr Leu Arg His Ala Asn Cys Arg His Glu Tyr Pro Leu Ser Trp
            180                 185                 190         
Met Lys Glu Lys Ile Phe Ser Glu Val Thr Pro Lys Cys Glu Asp Cys
        195                 200                 205             
Gln Ser Leu Val Lys Pro Asp Ile Val Phe Phe Gly Glu Ser Leu Pro
    210                 215                 220                 
Ala Arg Phe Phe Ser Cys Met Gln Ser Asp Phe Leu Lys Val Asp Leu
225                 230                 235                 240 
Leu Leu Val Met Gly Thr Ser Leu Gln Val Gln Pro Phe Ala Ser Leu
                245                 250                 255     
Ile Ser Lys Ala Pro Leu Ser Thr Pro Arg Leu Leu Ile Asn Lys Glu
            260                 265                 270         
Lys Ala Gly Gln Ser Asp Pro Phe Leu Gly Met Ile Met Gly Leu Gly
        275                 280                 285             
Gly Gly Met Asp Phe Asp Ser Lys Lys Ala Tyr Arg Asp Val Ala Trp
    290                 295                 300                 
Leu Gly Glu Cys Asp Gln Gly Cys Leu Ala Leu Ala Glu Leu Leu Gly
305                 310                 315                 320 
Trp Lys Lys Glu Leu Glu Asp Leu Val Pro Lys Gly Ala Arg Gln His
                325                 330                 335     
Arg Cys Pro Val Gly Gly Gly Gly Pro Asn Pro Ser Thr Ser Ala Ser
            340                 345                 350         
Pro Lys Lys Ser Pro Pro Pro Ala Lys Asp Glu Ala Arg Thr Thr Glu
        355                 360                 365             
Arg Glu Lys Pro Gln
    370             


<210> 887
<211> 993
<212> PRT
<213> Homo sapiens

<400> 887
Ser Leu Trp Gly Thr Pro Arg Leu Pro Cys Ser Pro Gly Trp Gln Gly
 1               5                  10                  15      
Ala Thr Lys Arg Leu Leu Val Arg Ser Val Ser Gly Ala Ser Asn His
            20                  25                  30          
Gln Pro Asn Ser Asn Ser Gly Arg Tyr Arg Asp Thr Val Leu Leu Pro
        35                  40                  45              
Gln Thr Ser Phe Pro Met Lys Leu Leu Gly Arg Gln Gln Pro Asp Thr
    50                  55                  60                  
Glu Leu Glu Ile Gln Gln Lys Cys Gly Phe Ser Glu Leu Tyr Ser Trp
65                  70                  75                  80  
Gln Arg Glu Arg Lys Val Lys Thr Glu Phe Cys Leu His Asp Gly Pro
                85                  90                  95      
Pro Tyr Ala Asn Gly Asp Pro His Val Gly His Ala Leu Asn Lys Ile
            100                 105                 110         
Leu Lys Asp Ile Ala Asn Arg Phe His Met Met Asn Gly Ser Lys Ile
        115                 120                 125             
His Phe Val Pro Gly Trp Asp Cys His Gly Leu Pro Ile Glu Ile Lys
    130                 135                 140                 
Val Leu Ser Glu Leu Gly Arg Glu Ala Gln Asn Leu Ser Ala Met Glu
145                 150                 155                 160 
Ile Arg Lys Lys Ala Arg Ser Phe Ala Lys Ala Ala Ile Glu Lys Gln
                165                 170                 175     
Lys Ser Ala Phe Ile Arg Trp Gly Ile Met Ala Asp Trp Asn Asn Cys
            180                 185                 190         
Tyr Tyr Thr Phe Asp Gly Lys Tyr Glu Ala Lys Gln Leu Arg Thr Phe
        195                 200                 205             
Tyr Gln Met Tyr Asp Lys Gly Leu Val Tyr Arg Ser Tyr Lys Pro Val
    210                 215                 220                 
Phe Trp Ser Pro Ser Ser Arg Thr Ala Leu Ala Glu Ala Glu Leu Glu
225                 230                 235                 240 
Tyr Asn Pro Glu His Val Ser Arg Ser Ile Tyr Val Lys Phe Pro Leu
                245                 250                 255     
Leu Lys Pro Ser Pro Lys Leu Ala Ser Leu Ile Asp Gly Ser Ser Pro
            260                 265                 270         
Val Ser Ile Leu Val Trp Thr Thr Gln Pro Trp Thr Ile Pro Ala Asn
        275                 280                 285             
Glu Ala Val Cys Tyr Met Pro Glu Ser Lys Tyr Ala Val Val Lys Cys
    290                 295                 300                 
Ser Lys Ser Gly Asp Leu Tyr Val Leu Ala Ala Asp Lys Val Ala Ser
305                 310                 315                 320 
Val Ala Ser Thr Leu Glu Thr Thr Phe Glu Thr Ile Ser Thr Leu Ser
                325                 330                 335     
Gly Val Asp Leu Glu Asn Gly Thr Cys Ser His Pro Leu Ile Pro Asp
            340                 345                 350         
Lys Ala Ser Pro Leu Leu Pro Ala Asn His Val Thr Met Ala Lys Gly
        355                 360                 365             
Thr Gly Leu Val His Thr Ala Pro Ala His Gly Met Glu Asp Tyr Gly
    370                 375                 380                 
Val Ala Ser Gln His Asn Leu Pro Met Asp Cys Leu Val Asp Glu Asp
385                 390                 395                 400 
Gly Val Phe Thr Asp Val Ala Gly Pro Glu Leu Gln Asn Lys Ala Val
                405                 410                 415     
Leu Glu Glu Gly Thr Asp Val Val Ile Lys Met Leu Gln Thr Ala Lys
            420                 425                 430         
Asn Leu Leu Lys Glu Glu Lys Leu Val His Ser Tyr Pro Tyr Asp Trp
        435                 440                 445             
Arg Thr Lys Lys Pro Val Val Ile Arg Ala Ser Lys Gln Trp Phe Ile
    450                 455                 460                 
Asn Ile Thr Asp Ile Lys Thr Ala Ala Lys Glu Leu Leu Lys Lys Val
465                 470                 475                 480 
Lys Phe Ile Pro Gly Ser Ala Leu Asn Gly Met Val Glu Met Met Asp
                485                 490                 495     
Arg Arg Pro Tyr Trp Cys Ile Ser Arg Gln Arg Val Trp Gly Val Pro
            500                 505                 510         
Ile Pro Val Phe His His Lys Thr Lys Asp Glu Tyr Leu Ile Asn Ser
        515                 520                 525             
Gln Thr Thr Glu His Ile Val Lys Leu Val Glu Gln His Gly Ser Asp
    530                 535                 540                 
Ile Trp Trp Thr Leu Pro Pro Glu Gln Leu Leu Pro Lys Glu Val Leu
545                 550                 555                 560 
Ser Glu Val Gly Gly Pro Asp Ala Leu Glu Tyr Val Pro Gly Gln Asp
                565                 570                 575     
Ile Leu Asp Ile Trp Phe Asp Ser Gly Thr Ser Trp Ser Tyr Val Leu
            580                 585                 590         
Pro Gly Pro Asp Gln Arg Ala Asp Leu Tyr Leu Glu Gly Lys Asp Gln
        595                 600                 605             
Leu Gly Gly Trp Phe Gln Ser Ser Leu Leu Thr Ser Val Ala Ala Arg
    610                 615                 620                 
Lys Arg Ala Pro Tyr Lys Thr Val Ile Val His Gly Phe Thr Leu Gly
625                 630                 635                 640 
Glu Lys Gly Glu Lys Met Ser Lys Ser Leu Gly Asn Val Ile His Pro
                645                 650                 655     
Asp Val Val Val Asn Gly Gly Gln Asp Gln Ser Lys Glu Pro Pro Tyr
            660                 665                 670         
Gly Ala Asp Val Leu Arg Trp Trp Val Ala Asp Ser Asn Val Phe Thr
        675                 680                 685             
Glu Val Ala Ile Gly Pro Ser Val Leu Asn Ala Ala Arg Asp Asp Ile
    690                 695                 700                 
Ser Lys Leu Arg Asn Thr Leu Arg Phe Leu Leu Gly Asn Val Ala Asp
705                 710                 715                 720 
Phe Asn Pro Glu Thr Asp Ser Ile Pro Val Asn Asp Met Tyr Val Ile
                725                 730                 735     
Asp Gln Tyr Met Leu His Leu Leu Gln Asp Leu Ala Asn Lys Ile Thr
            740                 745                 750         
Glu Leu Tyr Lys Gln Tyr Asp Phe Gly Lys Val Val Arg Leu Leu Arg
        755                 760                 765             
Thr Phe Tyr Thr Arg Glu Leu Ser Asn Phe Tyr Phe Ser Ile Ile Lys
    770                 775                 780                 
Asp Arg Leu Tyr Cys Glu Lys Glu Asn Asp Pro Lys Arg Arg Ser Cys
785                 790                 795                 800 
Gln Thr Ala Leu Val Glu Ile Leu Asp Val Ile Val Arg Ser Phe Ala
                805                 810                 815     
Pro Ile Leu Pro His Leu Ala Glu Glu Val Phe Gln His Ile Pro Tyr
            820                 825                 830         
Ile Lys Glu Pro Lys Ser Val Phe Arg Thr Gly Trp Ile Ser Thr Ser
        835                 840                 845             
Ser Ile Trp Lys Lys Pro Gly Leu Glu Glu Ala Val Glu Ser Ala Cys
    850                 855                 860                 
Ala Met Arg Asp Ser Phe Leu Gly Ser Ile Pro Gly Lys Asn Ala Ala
865                 870                 875                 880 
Glu Tyr Lys Val Ile Thr Val Ile Glu Pro Gly Leu Leu Phe Glu Ile
                885                 890                 895     
Ile Glu Met Leu Gln Ser Glu Glu Thr Ser Ser Thr Ser Gln Leu Asn
            900                 905                 910         
Glu Leu Met Met Ala Ser Glu Ser Thr Leu Leu Ala Gln Glu Pro Arg
        915                 920                 925             
Glu Met Thr Ala Asp Val Ile Glu Leu Lys Gly Lys Phe Leu Ile Asn
    930                 935                 940                 
Leu Glu Gly Gly Asp Ile Arg Glu Glu Ser Ser Tyr Lys Val Ile Val
945                 950                 955                 960 
Met Pro Thr Thr Lys Glu Lys Cys Pro Arg Cys Trp Lys Tyr Thr Ala
                965                 970                 975     
Glu Ser Ser Asp Thr Leu Cys Pro Arg Cys Ala Glu Val Val Ser Gly
            980                 985                 990         
Lys
    


<210> 888
<211> 586
<212> PRT
<213> Homo sapiens

<400> 888
Met His Pro Leu Gln Cys Val Leu Gln Val Gln Arg Ser Leu Gly Trp
 1               5                  10                  15      
Gly Pro Leu Ala Ser Val Ser Trp Leu Ser Leu Arg Met Cys Arg Ala
            20                  25                  30          
His Ser Ser Leu Ser Ser Thr Met Cys Pro Ser Pro Glu Arg Gln Glu
        35                  40                  45              
Asp Gly Ala Arg Lys Asp Phe Ser Ser Arg Leu Ala Ala Gly Pro Thr
    50                  55                  60                  
Phe Gln His Phe Leu Lys Ser Ala Ser Ala Pro Gln Glu Lys Leu Ser
65                  70                  75                  80  
Ser Glu Val Glu Asp Pro Pro Pro Tyr Leu Met Met Asp Glu Leu Leu
                85                  90                  95      
Gly Arg Gln Arg Lys Val Tyr Leu Glu Thr Tyr Gly Cys Gln Met Asn
            100                 105                 110         
Val Asn Asp Thr Glu Ile Ala Trp Ser Ile Leu Gln Lys Ser Gly Tyr
        115                 120                 125             
Leu Arg Thr Ser Asn Leu Gln Glu Ala Asp Val Ile Leu Leu Val Thr
    130                 135                 140                 
Cys Ser Ile Arg Glu Lys Ala Glu Gln Thr Ile Trp Asn Arg Leu His
145                 150                 155                 160 
Gln Leu Lys Ala Leu Lys Thr Arg Arg Pro Arg Ser Arg Val Pro Leu
                165                 170                 175     
Arg Ile Gly Ile Leu Gly Cys Met Ala Glu Arg Leu Lys Glu Glu Ile
            180                 185                 190         
Leu Asn Arg Glu Lys Met Val Asp Ile Leu Ala Gly Pro Asp Ala Tyr
        195                 200                 205             
Arg Asp Leu Pro Gly Cys Trp Leu Met Leu Ser Arg Ala Ser Lys Leu
    210                 215                 220                 
Pro Thr Cys Cys Ser Leu Trp Thr Arg Pro Met Leu Met Ser Cys Gln
225                 230                 235                 240 
Ser Arg Gln Gly Ala Ser Ala Thr Ser Ala Phe Val Ser Ile Met Arg
                245                 250                 255     
Gly Cys Asp Asn Met Cys Ser Tyr Cys Ile Val Leu Ser Pro Gly Ala
            260                 265                 270         
Gly Arg Gly Val Gly Leu Leu Pro His Ser Arg Gly Ser Glu Glu Ala
        275                 280                 285             
Phe Leu Ala Gly Leu Lys Glu Val Thr Leu Leu Gly Gln Asn Val Asn
    290                 295                 300                 
Ser Phe Arg Asp Asn Ser Glu Val Gln Phe Asn Ser Ala Val Pro Thr
305                 310                 315                 320 
Asn Leu Ser Arg Gly Phe Thr Thr Asn Tyr Lys Thr Lys Gln Gly Gly
                325                 330                 335     
Leu Arg Phe Ala His Leu Leu Asp Gln Val Ser Arg Val Asp Pro Glu
            340                 345                 350         
Met Arg Ile Arg Phe Thr Ser Pro His Pro Lys Asp Phe Pro Asp Glu
        355                 360                 365             
Val Leu Gln Leu Ile His Glu Arg Asp Asn Ile Cys Lys Gln Ile His
    370                 375                 380                 
Leu Pro Ala Gln Ser Gly Ser Ser Arg Val Leu Glu Ala Met Arg Arg
385                 390                 395                 400 
Gly Tyr Ser Arg Glu Ala Tyr Val Glu Leu Val His His Ile Arg Glu
                405                 410                 415     
Ser Ile Pro Gly Val Ser Leu Ser Ser Asp Phe Ile Ala Gly Phe Cys
            420                 425                 430         
Gly Glu Thr Glu Glu Asp His Val Gln Thr Val Ser Leu Leu Arg Glu
        435                 440                 445             
Val Gln Tyr Asn Met Gly Phe Leu Phe Ala Tyr Ser Met Arg Gln Lys
    450                 455                 460                 
Thr Arg Ala Tyr His Arg Leu Lys Asp Asp Val Pro Glu Glu Val Lys
465                 470                 475                 480 
Leu Arg Arg Leu Glu Glu Leu Ile Thr Ile Phe Arg Glu Glu Ala Ser
                485                 490                 495     
Lys Ala Asn Gln Thr Ser Val Gly Cys Thr Gln Leu Val Leu Val Glu
            500                 505                 510         
Gly Leu Ser Lys Arg Ser Ala Thr Asp Leu Cys Gly Arg Asn Asp Gly
        515                 520                 525             
Asn Leu Lys Val Ile Phe Pro Asp Ala Glu Met Glu Asp Val Asn Asn
    530                 535                 540                 
Pro Gly Leu Arg Val Arg Ala Gln Pro Gly Asp Tyr Val Leu Val Lys
545                 550                 555                 560 
Ile Thr Ser Ala Ser Ser Gln Thr Leu Arg Gly His Val Leu Cys Arg
                565                 570                 575     
Thr Thr Leu Arg Asp Ser Ser Ala Tyr Cys
            580                 585     


<210> 889
<211> 112
<212> PRT
<213> Homo sapiens

<400> 889
Met Gln Asp Thr Gly Ser Val Val Pro Leu His Trp Phe Gly Phe Gly
 1               5                  10                  15      
Tyr Ala Ala Leu Val Ala Ser Gly Gly Ile Ile Gly Tyr Val Lys Ala
            20                  25                  30          
Gly Ser Val Pro Ser Leu Ala Ala Gly Leu Leu Phe Gly Ser Leu Ala
        35                  40                  45              
Gly Leu Gly Ala Tyr Gln Leu Ser Gln Asp Pro Arg Asn Val Trp Val
    50                  55                  60                  
Phe Leu Ala Thr Ser Gly Thr Leu Ala Gly Ile Met Gly Met Arg Phe
65                  70                  75                  80  
Tyr His Ser Gly Lys Phe Met Pro Ala Gly Leu Ile Ala Gly Ala Ser
                85                  90                  95      
Leu Leu Met Val Ala Lys Val Gly Val Ser Met Phe Asn Arg Pro His
            100                 105                 110         


<210> 890
<211> 468
<212> PRT
<213> Homo sapiens

<400> 890
Met Ala Ala Arg Leu Val Ser Arg Cys Gly Ala Val Arg Ala Ala Pro
 1               5                  10                  15      
His Ser Gly Pro Leu Ala Val Leu Ala Gln Val Val Arg Arg Ser Thr
            20                  25                  30          
Asp Thr Val Tyr Asp Val Val Val Ser Gly Gly Gly Leu Val Gly Ala
        35                  40                  45              
Ala Met Ala Cys Ala Leu Gly Tyr Asp Ile His Phe His Asp Lys Lys
    50                  55                  60                  
Ile Leu Leu Leu Glu Ala Gly Pro Lys Lys Val Leu Glu Lys Leu Ser
65                  70                  75                  80  
Glu Thr Tyr Ser Asn Arg Val Ser Ser Ile Ser Pro Gly Ser Ala Thr
                85                  90                  95      
Leu Leu Ser Ser Phe Gly Ala Trp Asp His Ile Cys Asn Met Arg Tyr
            100                 105                 110         
Arg Ala Phe Arg Arg Met Gln Val Trp Asp Ala Cys Ser Glu Ala Leu
        115                 120                 125             
Ile Met Phe Asp Lys Asp Asn Leu Asp Asp Met Gly Tyr Ile Val Glu
    130                 135                 140                 
Asn Asp Val Ile Met His Ala Leu Thr Lys Gln Leu Glu Ala Val Ser
145                 150                 155                 160 
Asp Arg Val Thr Val Leu Tyr Arg Ser Lys Ala Ile Arg Tyr Thr Trp
                165                 170                 175     
Pro Cys Pro Phe Pro Met Ala Asp Ser Ser Pro Trp Val His Ile Thr
            180                 185                 190         
Leu Gly Asp Gly Ser Thr Phe Gln Thr Lys Leu Leu Ile Gly Ala Asp
        195                 200                 205             
Gly His Asn Ser Gly Val Arg Gln Ala Val Gly Ile Gln Asn Val Ser
    210                 215                 220                 
Trp Asn Tyr Asp Gln Ser Ala Val Val Ala Thr Leu His Leu Ser Glu
225                 230                 235                 240 
Ala Thr Glu Asn Asn Val Ala Trp Gln Arg Phe Leu Pro Ser Gly Pro
                245                 250                 255     
Ile Ala Leu Leu Pro Leu Ser Asp Thr Leu Ser Ser Leu Val Trp Ser
            260                 265                 270         
Thr Ser His Glu His Ala Ala Glu Leu Val Ser Met Asp Glu Glu Lys
        275                 280                 285             
Phe Val Asp Ala Val Asn Ser Ala Phe Trp Ser Asp Ala Asp His Thr
    290                 295                 300                 
Asp Phe Ile Asp Thr Ala Gly Ala Met Leu Gln Tyr Pro Val Ser Leu
305                 310                 315                 320 
Leu Lys Pro Thr Lys Val Ser Ala Arg Gln Leu Pro Pro Ser Val Pro
                325                 330                 335     
Trp Val Asp Ala Lys Ser Arg Val Leu Phe Pro Leu Gly Leu Gly His
            340                 345                 350         
Ala Ala Glu Tyr Val Arg Pro Arg Val Ala Leu Ile Gly Asp Ala Ala
        355                 360                 365             
His Arg Val His Pro Leu Ala Gly Gln Gly Val Asn Met Gly Phe Gly
    370                 375                 380                 
Asp Ile Ser Ser Leu Ala His His Leu Ser Thr Ala Ala Phe Asn Gly
385                 390                 395                 400 
Lys Asp Leu Gly Ser Val Ser His Leu Thr Gly Tyr Glu Thr Glu Arg
                405                 410                 415     
Gln Arg His Asn Thr Ala Leu Leu Ala Ala Thr Asp Leu Leu Lys Arg
            420                 425                 430         
Leu Tyr Ser Thr Ser Ala Ser Pro Leu Val Leu Leu Arg Thr Trp Gly
        435                 440                 445             
Leu Gln Ala Thr Asn Ala Val Ser Pro Leu Lys Glu Gln Ile Met Ala
    450                 455                 460                 
Phe Ala Ser Lys
465             


<210> 891
<211> 208
<212> PRT
<213> Homo sapiens

<400> 891
Met Gly Glu Val Glu Ile Ser Gly Pro Gly Tyr Val Lys Met Cys Leu
 1               5                  10                  15      
His Ala Ala Arg Tyr Pro His Ala Ala Val Asn Gly Leu Phe Leu Ala
            20                  25                  30          
Pro Ala Thr Gly Ser Gly Glu Cys Leu Cys Leu Thr Asp Cys Val Pro
        35                  40                  45              
Leu Phe His Ser His Leu Ala Leu Ser Val Met Leu Glu Val Ala Leu
    50                  55                  60                  
Asn Gln Val Asp Val Trp Gly Ala Gln Ala Gly Leu Val Val Ala Gly
65                  70                  75                  80  
Tyr Tyr His Ala Asn Ala Ala Val Asn Asp Gln Ser Pro Gly Pro Leu
                85                  90                  95      
Ala Leu Lys Ile Ala Gly Arg Ile Ala Glu Phe Phe Pro Asp Ala Val
            100                 105                 110         
Leu Ile Met Leu Asp Asn Gln Lys Leu Val Pro Gln Pro Arg Val Pro
        115                 120                 125             
Pro Val Ile Val Leu Glu Asn Gln Gly Leu Arg Trp Val Pro Lys Asp
    130                 135                 140                 
Lys Asn Leu Val Met Trp Arg Asp Trp Glu Glu Ser Arg Gln Met Val
145                 150                 155                 160 
Gly Ala Leu Leu Glu Asp Arg Ala His Gln His Leu Val Asp Phe Asp
                165                 170                 175     
Cys His Leu Asp Asp Ile Arg Gln Asp Trp Thr Asn Gln Arg Leu Asn
            180                 185                 190         
Thr Gln Ile Thr Gln Trp Val Gly Pro Thr Asn Gly Asn Gly Asn Ala
        195                 200                 205             


<210> 892
<211> 137
<212> PRT
<213> Homo sapiens

<400> 892
Met Val His Leu Thr Thr Leu Leu Cys Lys Ala Tyr Arg Gly Gly His
 1               5                  10                  15      
Leu Thr Ile Arg Leu Ala Leu Gly Gly Cys Thr Asn Arg Pro Phe Tyr
            20                  25                  30          
Arg Ile Val Ala Ala His Asn Lys Cys Pro Arg Asp Gly Arg Phe Val
        35                  40                  45              
Glu Gln Leu Gly Ser Tyr Asp Pro Leu Pro Asn Ser His Gly Glu Lys
    50                  55                  60                  
Leu Val Ala Leu Asn Leu Asp Arg Ile Arg His Trp Ile Gly Cys Gly
65                  70                  75                  80  
Ala His Leu Ser Lys Pro Met Glu Lys Leu Leu Gly Leu Ala Gly Phe
                85                  90                  95      
Phe Pro Leu His Pro Met Met Ile Thr Asn Ala Glu Arg Leu Arg Arg
            100                 105                 110         
Lys Arg Ala Arg Glu Val Leu Leu Ala Ser Gln Lys Thr Asp Ala Glu
        115                 120                 125             
Ala Thr Asp Thr Glu Ala Thr Glu Thr
    130                 135         


<210> 893
<211> 137
<212> PRT
<213> Homo sapiens

<400> 893
Met Val His Leu Thr Thr Leu Leu Cys Lys Ala Tyr Arg Gly Gly His
 1               5                  10                  15      
Leu Thr Ile Arg Leu Ala Leu Gly Gly Cys Thr Asn Arg Pro Phe Tyr
            20                  25                  30          
Arg Ile Val Ala Ala His Asn Lys Cys Pro Arg Asp Gly Arg Phe Val
        35                  40                  45              
Glu Gln Leu Gly Ser Tyr Asp Pro Leu Pro Asn Ser His Gly Glu Lys
    50                  55                  60                  
Leu Val Ala Leu Asn Leu Asp Arg Ile Arg His Trp Ile Gly Cys Gly
65                  70                  75                  80  
Ala His Leu Ser Lys Pro Met Glu Lys Leu Leu Gly Leu Ala Gly Phe
                85                  90                  95      
Phe Pro Leu His Pro Met Met Ile Thr Asn Ala Glu Arg Leu Arg Arg
            100                 105                 110         
Lys Arg Ala Arg Glu Val Leu Leu Ala Ser Gln Lys Thr Asp Ala Glu
        115                 120                 125             
Ala Thr Asp Thr Glu Ala Thr Glu Thr
    130                 135         


<210> 894
<211> 504
<212> PRT
<213> Homo sapiens

<400> 894
Met Arg Leu Thr Pro Phe Ser Leu Ser Thr Gly Asn Ser Phe Arg Tyr
 1               5                  10                  15      
Ser Arg Arg Leu Lys Lys Asn Ile Phe Gly Thr Ala Pro Ala Leu Arg
            20                  25                  30          
Val Ser Glu Met Ser Leu Arg Pro Ser Ser Arg Ile Phe Pro Cys Phe
        35                  40                  45              
Ser Arg Asn Gly Leu Asp Phe Thr Ile Val Ile Thr Leu Ala Gln Pro
    50                  55                  60                  
Pro Val Pro Gly Ile Ser Phe Ile Val Ala Lys Pro Arg Leu Phe Pro
65                  70                  75                  80  
Gly Ala Gly Ser Ala Gly Cys Gly Leu Leu Glu Arg Leu Phe Leu Ser
                85                  90                  95      
Leu Leu Leu Gly Thr Gly Leu Arg Trp Cys Leu Arg Gly Cys Phe Pro
            100                 105                 110         
Gly Ala Arg Phe Cys Ser Thr Thr Ser Pro Glu Gly His Thr Thr Phe
        115                 120                 125             
Thr Gly Leu Arg Arg Ser Ala Arg Thr Gln Arg Leu Ala Gln Gly Pro
    130                 135                 140                 
Lys Pro Gly Pro Pro Ala Ala Thr Val Ala Arg Gln Thr Ser Arg Val
145                 150                 155                 160 
Ser Pro Ala Pro Pro Cys Ser Leu Arg Pro Gly Leu Arg His Glu Ser
                165                 170                 175     
Ala Pro Ser Gly Ile Gly Asp Val Thr Ala Arg Gly Ala Leu Arg Gly
            180                 185                 190         
Leu Gly Cys Thr Val Arg Val Thr Ala Ala Cys Gly Gly Asn His Gly
        195                 200                 205             
Cys Ser Gln Met Leu His Phe Val Phe Lys Val Gly Asn Arg Phe Gln
    210                 215                 220                 
Thr Ala Arg Phe Tyr Arg Asp Val Leu Gly Met Lys Val Leu Arg His
225                 230                 235                 240 
Glu Glu Phe Glu Glu Gly Cys Lys Ala Ala Cys Asn Gly Pro Tyr Asp
                245                 250                 255     
Gly Lys Trp Ser Lys Thr Met Val Gly Phe Gly Pro Glu Asp Asp His
            260                 265                 270         
Phe Val Ala Glu Leu Thr Tyr Asn Tyr Gly Val Gly Asp Tyr Lys Leu
        275                 280                 285             
Gly Asn Asp Phe Met Gly Ile Thr Leu Ala Ser Ser Gln Ala Val Ser
    290                 295                 300                 
Asn Ala Arg Lys Leu Glu Trp Pro Leu Thr Glu Val Ala Glu Gly Val
305                 310                 315                 320 
Phe Glu Thr Glu Ala Pro Gly Gly Tyr Lys Phe Tyr Leu Gln Asn Arg
                325                 330                 335     
Ser Leu Pro Gln Ser Asp Pro Val Leu Lys Val Thr Leu Ala Val Ser
            340                 345                 350         
Asp Leu Gln Lys Ser Leu Asn Tyr Trp Cys Asn Leu Leu Gly Met Lys
        355                 360                 365             
Ile Tyr Glu Lys Asp Glu Glu Lys Gln Arg Ala Leu Leu Gly Tyr Ala
    370                 375                 380                 
Asp Asn Gln Cys Lys Leu Glu Leu Gln Gly Val Lys Gly Gly Val Asp
385                 390                 395                 400 
His Ala Ala Ala Phe Gly Arg Ile Ala Phe Ser Cys Pro Gln Lys Glu
                405                 410                 415     
Leu Pro Asp Leu Glu Asp Leu Met Lys Arg Glu Asn Gln Lys Ile Leu
            420                 425                 430         
Thr Pro Leu Val Ser Leu Asp Thr Pro Gly Lys Ala Thr Val Gln Val
        435                 440                 445             
Val Ile Leu Ala Asp Pro Asp Gly His Glu Ile Cys Phe Val Gly Asp
    450                 455                 460                 
Glu Ala Phe Arg Glu Leu Ser Lys Met Asp Pro Glu Gly Ser Lys Leu
465                 470                 475                 480 
Leu Asp Asp Ala Met Ala Ala Asp Lys Ser Asp Glu Trp Phe Ala Lys
                485                 490                 495     
His Asn Lys Pro Lys Ala Ser Gly
            500                 


<210> 895
<211> 226
<212> PRT
<213> Homo sapiens

<400> 895
Met Gly Pro Leu Pro Arg Thr Val Glu Leu Phe Tyr Asp Val Leu Ser
 1               5                  10                  15      
Pro Tyr Ser Trp Leu Gly Phe Glu Ile Leu Cys Arg Tyr Gln Asn Ile
            20                  25                  30          
Trp Asn Ile Asn Leu Gln Leu Arg Pro Ser Leu Ile Thr Gly Ile Met
        35                  40                  45              
Lys Asp Ser Gly Asn Lys Pro Pro Gly Leu Leu Pro Arg Lys Gly Leu
    50                  55                  60                  
Tyr Met Ala Asn Asp Leu Lys Leu Leu Arg His His Leu Gln Ile Pro
65                  70                  75                  80  
Ile His Phe Pro Lys Asp Phe Leu Ser Val Met Leu Glu Lys Gly Ser
                85                  90                  95      
Leu Ser Ala Met Arg Phe Leu Thr Ala Val Asn Leu Glu His Pro Glu
            100                 105                 110         
Met Leu Glu Lys Ala Ser Arg Glu Leu Trp Met Arg Val Trp Ser Arg
        115                 120                 125             
Asn Glu Asp Ile Thr Glu Pro Gln Ser Ile Leu Ala Ala Ala Glu Lys
    130                 135                 140                 
Ala Gly Met Ser Ala Glu Gln Ala Gln Gly Leu Leu Glu Lys Ile Ala
145                 150                 155                 160 
Thr Pro Lys Val Lys Asn Gln Leu Lys Glu Thr Thr Glu Ala Ala Cys
                165                 170                 175     
Arg Tyr Gly Ala Phe Gly Leu Pro Ile Thr Val Ala His Val Asp Gly
            180                 185                 190         
Gln Thr His Met Leu Phe Gly Ser Asp Arg Met Glu Leu Leu Ala His
        195                 200                 205             
Leu Leu Gly Glu Lys Trp Met Gly Pro Ile Pro Pro Ala Val Asn Ala
    210                 215                 220                 
Arg Leu
225     


<210> 896
<211> 242
<212> PRT
<213> Homo sapiens

<400> 896
Met Val Ala Pro Ala Val Lys Val Ala Arg Gly Trp Ser Gly Leu Ala
 1               5                  10                  15      
Leu Gly Val Arg Arg Ala Val Leu Gln Leu Pro Gly Leu Thr Gln Val
            20                  25                  30          
Arg Trp Ser Arg Tyr Ser Pro Glu Phe Lys Asp Pro Leu Ile Asp Lys
        35                  40                  45              
Glu Tyr Tyr Arg Lys Pro Val Glu Glu Leu Thr Glu Glu Glu Lys Tyr
    50                  55                  60                  
Val Arg Glu Leu Lys Lys Thr Gln Leu Ile Lys Ala Ala Pro Ala Gly
65                  70                  75                  80  
Lys Thr Ser Ser Val Phe Glu Asp Pro Val Ile Ser Lys Phe Thr Asn
                85                  90                  95      
Met Met Met Ile Gly Gly Asn Lys Val Leu Ala Arg Ser Leu Met Ile
            100                 105                 110         
Gln Thr Leu Glu Ala Val Lys Arg Lys Gln Phe Glu Lys Tyr His Ala
        115                 120                 125             
Ala Ser Ala Glu Glu Gln Ala Thr Ile Glu Arg Asn Pro Tyr Thr Ile
    130                 135                 140                 
Phe His Gln Ala Leu Lys Asn Cys Glu Pro Met Ile Gly Leu Val Pro
145                 150                 155                 160 
Ile Leu Lys Gly Gly Arg Phe Tyr Gln Val Pro Val Pro Leu Pro Asp
                165                 170                 175     
Arg Arg Arg Arg Phe Leu Ala Met Lys Trp Met Ile Thr Glu Cys Arg
            180                 185                 190         
Asp Lys Lys His Gln Arg Thr Leu Met Pro Glu Lys Leu Ser His Lys
        195                 200                 205             
Leu Leu Glu Ala Phe His Asn Gln Gly Pro Val Ile Lys Arg Lys His
    210                 215                 220                 
Asp Leu His Lys Met Ala Glu Ala Asn Arg Ala Leu Ala His Tyr Arg
225                 230                 235                 240 
Trp Trp
        


<210> 897
<211> 379
<212> PRT
<213> Homo sapiens

<400> 897
Met Leu Arg Phe Leu Gly Glu Lys Ala Ala Ala Lys Arg Gln Val Leu
 1               5                  10                  15      
Asn Ala Asp Ser Val Glu Gln Ser Phe Val Gly Leu Lys Gln Leu Ile
            20                  25                  30          
Ser Cys Arg Asn Trp Arg Ala Ala Val Asp Leu Cys Gly Arg Leu Leu
        35                  40                  45              
Thr Ala His Gly Gln Gly Tyr Gly Lys Ser Gly Leu Leu Thr Ser His
    50                  55                  60                  
Thr Thr Asp Ser Leu Gln Leu Trp Phe Val Arg Leu Ala Leu Leu Val
65                  70                  75                  80  
Lys Leu Gly Leu Phe Gln Asn Ala Glu Met Glu Phe Glu Pro Val Gly
                85                  90                  95      
Asn Leu Asp Gln Pro Asp Leu Tyr Tyr Glu Tyr Tyr Pro His Val Tyr
            100                 105                 110         
Pro Gly Arg Arg Gly Ser Met Val Pro Phe Ser Met Arg Ile Leu His
        115                 120                 125             
Ala Asp Leu Gln Gln Tyr Leu Gly Asn Pro Gln Glu Ser Leu Asp Arg
    130                 135                 140                 
Leu His Lys Val Lys Thr Val Cys Ser Lys Ile Leu Ala Asn Leu Glu
145                 150                 155                 160 
Gln Gly Leu Ala Glu Asp Gly Gly Met Ser Ser Val Thr Gln Glu Gly
                165                 170                 175     
Arg Gln Ala Ser Ile Arg Leu Trp Arg Ser Arg Leu Gly Arg Val Met
            180                 185                 190         
Tyr Ser Met Ala Asn Cys Leu Leu Leu Met Lys Asp Tyr Val Leu Ala
        195                 200                 205             
Val Glu Ala Tyr His Ser Val Ile Lys Tyr Tyr Pro Glu Gln Glu Pro
    210                 215                 220                 
Gln Leu Leu Ser Gly Ile Gly Arg Ile Ser Leu Gln Ile Gly Asp Ile
225                 230                 235                 240 
Lys Thr Ala Glu Lys Tyr Phe Gln Asp Val Glu Lys Val Thr Gln Lys
                245                 250                 255     
Leu Asp Gly Leu Gln Gly Lys Ile Met Val Leu Met Asn Ser Ala Phe
            260                 265                 270         
Leu His Leu Gly Gln Asn Asn Phe Ala Glu Ala His Arg Phe Phe Thr
        275                 280                 285             
Glu Ile Leu Arg Met Asp Pro Arg Asn Ala Val Ala Asn Asn Asn Ala
    290                 295                 300                 
Ala Val Cys Leu Leu Tyr Leu Gly Lys Leu Lys Asp Ser Leu Arg Gln
305                 310                 315                 320 
Leu Glu Ala Met Val Gln Gln Asp Pro Arg His Tyr Leu His Glu Ser
                325                 330                 335     
Val Leu Phe Asn Leu Thr Thr Met Tyr Glu Leu Glu Ser Ser Arg Ser
            340                 345                 350         
Met Gln Lys Lys Gln Ala Leu Leu Glu Ala Val Ala Gly Lys Glu Gly
        355                 360                 365             
Asp Ser Phe Asn Thr Gln Cys Leu Lys Leu Ala
    370                 375                 


<210> 898
<211> 296
<212> PRT
<213> Homo sapiens

<400> 898
Met Ala Thr Ser Ser Ala Ala Leu Pro Arg Ile Leu Gly Ala Gly Ala
 1               5                  10                  15      
Arg Ala Pro Ser Arg Trp Leu Gly Phe Leu Gly Lys Ala Thr Pro Arg
            20                  25                  30          
Pro Ala Arg Pro Ser Arg Arg Thr Leu Gly Ser Ala Thr Ala Leu Met
        35                  40                  45              
Ile Arg Glu Ser Glu Asp Ser Thr Asp Phe Asn Asp Lys Ile Leu Asn
    50                  55                  60                  
Glu Pro Leu Lys His Ser Asp Phe Phe Asn Val Lys Glu Leu Phe Ser
65                  70                  75                  80  
Val Arg Ser Leu Phe Asp Ala Arg Val His Leu Gly His Lys Ala Gly
                85                  90                  95      
Cys Arg His Arg Phe Met Glu Pro Tyr Ile Phe Gly Ser Arg Leu Asp
            100                 105                 110         
His Asp Ile Ile Asp Leu Glu Gln Thr Ala Thr His Leu Gln Leu Ala
        115                 120                 125             
Leu Asn Phe Thr Ala His Met Ala Tyr Arg Lys Gly Ile Ile Leu Phe
    130                 135                 140                 
Ile Ser Arg Asn Arg Gln Phe Ser Tyr Leu Ile Glu Asn Met Ala Arg
145                 150                 155                 160 
Asp Cys Gly Glu Tyr Ala His Thr Arg Tyr Phe Arg Gly Gly Met Leu
                165                 170                 175     
Thr Asn Ala Arg Leu Leu Phe Gly Pro Thr Val Arg Leu Pro Asp Leu
            180                 185                 190         
Ile Ile Phe Leu His Thr Leu Asn Asn Ile Phe Glu Pro His Val Ala
        195                 200                 205             
Val Arg Asp Ala Ala Lys Met Asn Ile Pro Thr Val Gly Ile Val Asp
    210                 215                 220                 
Thr Asn Cys Asn Pro Cys Leu Ile Thr Tyr Pro Val Pro Gly Asn Asp
225                 230                 235                 240 
Asp Ser Pro Leu Ala Val His Leu Tyr Cys Arg Leu Phe Gln Thr Ala
                245                 250                 255     
Ile Thr Arg Ala Lys Glu Lys Arg Gln Gln Val Glu Ala Leu Tyr Arg
            260                 265                 270         
Leu Gln Gly Gln Lys Glu Pro Gly Asp Gln Gly Pro Ala His Pro Pro
        275                 280                 285             
Gly Ala Asp Met Ser His Ser Leu
    290                 295     


<210> 899
<211> 296
<212> PRT
<213> Homo sapiens

<400> 899
Met Ala Thr Ser Ser Ala Ala Leu Pro Arg Ile Leu Gly Ala Gly Ala
 1               5                  10                  15      
Arg Ala Pro Ser Arg Trp Leu Gly Phe Leu Gly Lys Ala Thr Pro Arg
            20                  25                  30          
Pro Ala Arg Pro Ser Arg Arg Thr Leu Gly Ser Ala Thr Ala Leu Met
        35                  40                  45              
Ile Arg Glu Ser Glu Asp Ser Thr Asp Phe Asn Asp Lys Ile Leu Asn
    50                  55                  60                  
Glu Pro Leu Lys His Ser Asp Phe Phe Asn Val Lys Glu Leu Phe Ser
65                  70                  75                  80  
Val Arg Ser Leu Phe Asp Ala Arg Val His Leu Gly His Lys Ala Gly
                85                  90                  95      
Cys Arg His Arg Phe Met Glu Pro Tyr Ile Phe Gly Ser Arg Leu Asp
            100                 105                 110         
His Asp Ile Ile Asp Leu Glu Gln Thr Ala Thr His Leu Gln Leu Ala
        115                 120                 125             
Leu Asn Phe Thr Ala His Met Ala Tyr Arg Lys Gly Ile Ile Leu Phe
    130                 135                 140                 
Ile Ser Arg Asn Arg Gln Phe Ser Tyr Leu Ile Glu Asn Met Ala Arg
145                 150                 155                 160 
Asp Cys Gly Glu Tyr Ala His Thr Arg Tyr Phe Arg Gly Gly Met Leu
                165                 170                 175     
Thr Asn Ala Arg Leu Leu Phe Gly Pro Thr Val Arg Leu Pro Asp Leu
            180                 185                 190         
Ile Ile Phe Leu His Thr Leu Asn Asn Ile Phe Glu Pro His Val Ala
        195                 200                 205             
Val Arg Asp Ala Ala Lys Met Asn Ile Pro Thr Val Gly Ile Val Asp
    210                 215                 220                 
Thr Asn Cys Asn Pro Cys Leu Ile Thr Tyr Pro Val Pro Gly Asn Asp
225                 230                 235                 240 
Asp Ser Pro Leu Ala Val His Leu Tyr Cys Arg Leu Phe Gln Thr Ala
                245                 250                 255     
Ile Thr Arg Ala Lys Glu Lys Arg Gln Gln Val Glu Ala Leu Tyr Arg
            260                 265                 270         
Leu Gln Gly Gln Lys Glu Pro Gly Asp Gln Gly Pro Ala His Pro Pro
        275                 280                 285             
Gly Ala Asp Met Ser His Ser Leu
    290                 295     


<210> 900
<211> 273
<212> PRT
<213> Homo sapiens

<400> 900
Met Arg Gly Ser Gln Glu Val Leu Leu Met Trp Leu Leu Val Leu Ala
 1               5                  10                  15      
Val Gly Gly Thr Glu His Ala Tyr Arg Pro Gly Arg Arg Val Cys Ala
            20                  25                  30          
Val Arg Ala His Gly Asp Pro Val Ser Glu Ser Phe Val Gln Arg Val
        35                  40                  45              
Tyr Gln Pro Phe Leu Thr Thr Cys Asp Gly His Arg Ala Cys Ser Thr
    50                  55                  60                  
Tyr Arg Thr Ile Tyr Arg Thr Ala Tyr Arg Arg Ser Pro Gly Leu Ala
65                  70                  75                  80  
Pro Ala Arg Pro Arg Tyr Ala Cys Cys Pro Gly Trp Lys Arg Thr Ser
                85                  90                  95      
Gly Leu Pro Gly Ala Cys Gly Ala Ala Ile Cys Gln Pro Pro Cys Arg
            100                 105                 110         
Asn Gly Gly Ser Cys Val Gln Pro Gly Arg Cys Arg Cys Pro Ala Gly
        115                 120                 125             
Trp Arg Gly Asp Thr Cys Gln Ser Asp Val Asp Glu Cys Ser Ala Arg
    130                 135                 140                 
Arg Gly Gly Cys Pro Gln Arg Cys Val Asn Thr Ala Gly Ser Tyr Trp
145                 150                 155                 160 
Cys Gln Cys Trp Glu Gly His Ser Leu Ser Ala Asp Gly Thr Leu Cys
                165                 170                 175     
Val Pro Lys Gly Gly Pro Pro Arg Val Ala Pro Asn Pro Thr Gly Val
            180                 185                 190         
Asp Ser Ala Met Lys Glu Glu Val Gln Arg Leu Gln Ser Arg Val Asp
        195                 200                 205             
Leu Leu Glu Glu Lys Leu Gln Leu Val Leu Ala Pro Leu His Ser Leu
    210                 215                 220                 
Ala Ser Gln Ala Leu Glu His Gly Leu Pro Asp Pro Gly Ser Leu Leu
225                 230                 235                 240 
Val His Ser Phe Gln Gln Leu Gly Arg Ile Asp Ser Leu Ser Glu Gln
                245                 250                 255     
Ile Ser Phe Leu Glu Glu Gln Leu Gly Ser Cys Ser Cys Lys Lys Asp
            260                 265                 270         
Ser
    


<210> 901
<211> 209
<212> PRT
<213> Homo sapiens

<400> 901
Met Ala Leu Leu Ala Glu His Leu Leu Lys Pro Leu Pro Ala Asp Lys
 1               5                  10                  15      
Gln Ile Glu Thr Gly Pro Phe Leu Glu Ala Val Ser His Leu Pro Pro
            20                  25                  30          
Phe Phe Asp Cys Leu Gly Ser Pro Val Phe Thr Pro Ile Lys Ala Asp
        35                  40                  45              
Ile Ser Gly Asn Ile Thr Lys Ile Lys Ala Val Tyr Asp Thr Asn Pro
    50                  55                  60                  
Ala Lys Phe Arg Thr Leu Gln Asn Ile Leu Glu Val Glu Lys Glu Met
65                  70                  75                  80  
Tyr Gly Ala Glu Trp Pro Lys Val Gly Ala Thr Leu Ala Leu Met Trp
                85                  90                  95      
Leu Lys Arg Gly Leu Arg Phe Ile Gln Val Phe Leu Gln Ser Ile Cys
            100                 105                 110         
Asp Gly Glu Arg Asp Glu Asn His Pro Asn Leu Ile Arg Val Asn Ala
        115                 120                 125             
Thr Lys Ala Tyr Glu Met Ala Leu Lys Lys Tyr His Gly Trp Ile Val
    130                 135                 140                 
Gln Lys Ile Phe Gln Ala Ala Leu Tyr Ala Ala Pro Tyr Lys Ser Asp
145                 150                 155                 160 
Phe Leu Lys Ala Leu Ser Lys Gly Gln Asn Val Thr Glu Glu Glu Cys
                165                 170                 175     
Leu Glu Lys Ile Arg Leu Phe Leu Val Asn Tyr Thr Ala Thr Ile Asp
            180                 185                 190         
Val Ile Tyr Glu Met Tyr Thr Gln Met Asn Ala Glu Leu Asn Tyr Lys
        195                 200                 205             
Val
    


<210> 902
<211> 148
<212> PRT
<213> Homo sapiens

<400> 902
Met Ala Ser Val Val Leu Ala Leu Arg Thr Arg Thr Ala Val Thr Ser
 1               5                  10                  15      
Leu Leu Ser Pro Thr Pro Ala Thr Ala Leu Ala Val Arg Tyr Ala Ser
            20                  25                  30          
Lys Lys Ser Gly Gly Ser Ser Lys Asn Leu Gly Gly Lys Ser Ser Gly
        35                  40                  45              
Arg Arg Gln Gly Ile Lys Lys Met Glu Gly His Tyr Val His Ala Gly
    50                  55                  60                  
Asn Ile Ile Ala Thr Gln Arg His Phe Arg Trp His Pro Gly Ala His
65                  70                  75                  80  
Val Gly Val Gly Lys Asn Lys Cys Leu Tyr Ala Leu Glu Glu Gly Ile
                85                  90                  95      
Val Arg Tyr Thr Lys Glu Val Tyr Val Pro His Pro Arg Asn Thr Glu
            100                 105                 110         
Ala Val Asp Leu Ile Thr Arg Leu Pro Lys Gly Ala Val Leu Tyr Lys
        115                 120                 125             
Thr Phe Val His Val Val Pro Ala Lys Pro Glu Gly Thr Phe Lys Leu
    130                 135                 140                 
Val Ala Met Leu
145             


<210> 903
<211> 111
<212> PRT
<213> Homo sapiens

<400> 903
Met Ala Asp Trp Ala Arg Ala Gln Ser Pro Gly Ala Val Glu Glu Ile
 1               5                  10                  15      
Leu Asp Arg Glu Asn Lys Arg Met Ala Asp Ser Leu Ala Ser Lys Val
            20                  25                  30          
Thr Arg Leu Lys Ser Leu Ala Leu Asp Ile Asp Arg Asp Ala Glu Asp
        35                  40                  45              
Gln Asn Arg Tyr Leu Asp Gly Met Asp Ser Asp Phe Thr Ser Met Thr
    50                  55                  60                  
Ser Leu Leu Thr Gly Ser Val Lys Arg Phe Ser Thr Met Ala Arg Ser
65                  70                  75                  80  
Gly Gln Asp Asn Arg Lys Leu Leu Cys Gly Met Ala Val Gly Leu Ile
                85                  90                  95      
Val Ala Phe Phe Ile Leu Ser Tyr Phe Leu Ser Arg Ala Arg Thr
            100                 105                 110     


<210> 904
<211> 581
<212> PRT
<213> Homo sapiens

<400> 904
Met Pro Ala Pro Arg Ala Arg Glu Gln Pro Arg Val Pro Gly Glu Arg
 1               5                  10                  15      
Gln Pro Leu Leu Pro Arg Gly Ala Arg Gly Pro Arg Arg Trp Arg Arg
            20                  25                  30          
Ala Ala Gly Ala Ala Val Leu Leu Val Glu Met Leu Glu Arg Ala Ala
        35                  40                  45              
Phe Phe Gly Val Thr Ala Asn Leu Val Leu Tyr Leu Asn Ser Thr Asn
    50                  55                  60                  
Phe Asn Trp Thr Gly Glu Gln Ala Thr Arg Ala Ala Leu Val Phe Leu
65                  70                  75                  80  
Gly Ala Ser Tyr Leu Leu Ala Pro Val Gly Gly Trp Leu Ala Asp Val
                85                  90                  95      
Tyr Leu Gly Arg Tyr Arg Ala Val Ala Leu Ser Leu Leu Leu Tyr Leu
            100                 105                 110         
Ala Ala Ser Gly Leu Leu Pro Ala Thr Ala Phe Pro Asp Gly Arg Ser
        115                 120                 125             
Ser Phe Cys Gly Glu Met Pro Ala Ser Pro Leu Gly Pro Ala Cys Pro
    130                 135                 140                 
Ser Ala Gly Cys Pro Arg Ser Ser Pro Ser Pro Tyr Cys Ala Pro Val
145                 150                 155                 160 
Leu Tyr Ala Gly Leu Leu Leu Leu Gly Leu Ala Ala Ser Ser Val Arg
                165                 170                 175     
Ser Asn Leu Thr Ser Phe Gly Ala Asp Gln Val Met Asp Leu Gly Arg
            180                 185                 190         
Asp Ala Thr Arg Arg Phe Phe Asn Trp Phe Tyr Trp Ser Ile Asn Leu
        195                 200                 205             
Gly Ala Val Leu Ser Leu Leu Val Val Ala Phe Ile Gln Gln Asn Ile
    210                 215                 220                 
Ser Phe Leu Leu Gly Tyr Ser Ile Pro Val Gly Cys Val Gly Leu Ala
225                 230                 235                 240 
Phe Phe Ile Phe Leu Phe Ala Thr Pro Val Phe Ile Thr Lys Pro Pro
                245                 250                 255     
Met Gly Ser Gln Val Ser Ser Met Leu Lys Leu Ala Leu Gln Asn Cys
            260                 265                 270         
Cys Pro Gln Leu Trp Gln Arg His Ser Ala Arg Asp Arg Gln Cys Ala
        275                 280                 285             
Arg Val Leu Ala Asp Glu Arg Ser Pro Gln Pro Gly Ala Ser Pro Gln
    290                 295                 300                 
Glu Asp Ile Ala Asn Phe Gln Val Leu Val Lys Ile Leu Pro Val Met
305                 310                 315                 320 
Val Thr Leu Val Pro Tyr Trp Met Val Tyr Phe Gln Met Gln Ser Thr
                325                 330                 335     
Tyr Val Leu Gln Gly Leu His Leu His Ile Pro Asn Ile Phe Pro Ala
            340                 345                 350         
Asn Pro Ala Asn Ile Ser Val Ala Leu Arg Ala Gln Gly Ser Ser Tyr
        355                 360                 365             
Thr Ile Pro Glu Ala Trp Leu Leu Leu Ala Asn Val Val Val Val Leu
    370                 375                 380                 
Ile Leu Val Pro Leu Lys Asp Arg Leu Ile Asp Pro Leu Leu Leu Arg
385                 390                 395                 400 
Cys Lys Leu Leu Pro Ser Ala Leu Gln Lys Met Ala Leu Gly Met Phe
                405                 410                 415     
Phe Gly Phe Thr Ser Val Ile Val Ala Gly Val Leu Glu Met Glu Arg
            420                 425                 430         
Leu His Tyr Ile His His Asn Glu Thr Val Ser Gln Gln Ile Gly Glu
        435                 440                 445             
Val Leu Tyr Asn Ala Ala Pro Leu Ser Ile Trp Trp Gln Ile Pro Gln
    450                 455                 460                 
Tyr Leu Leu Ile Gly Ile Ser Glu Ile Phe Ala Ser Ile Pro Gly Leu
465                 470                 475                 480 
Glu Phe Ala Tyr Ser Glu Ala Pro Arg Ser Met Gln Gly Ala Ile Met
                485                 490                 495     
Gly Ile Phe Phe Cys Leu Ser Gly Val Gly Ser Leu Leu Gly Ser Ser
            500                 505                 510         
Leu Val Ala Leu Leu Ser Leu Pro Gly Gly Trp Leu His Cys Pro Lys
        515                 520                 525             
Asp Phe Gly Asn Ile Asn Asn Cys Arg Met Asp Leu Tyr Phe Phe Leu
    530                 535                 540                 
Leu Ala Gly Ile Gln Ala Val Thr Ala Leu Leu Phe Val Trp Ile Ala
545                 550                 555                 560 
Gly Arg Tyr Glu Arg Ala Ser Gln Gly Pro Ala Ser His Ser Arg Phe
                565                 570                 575     
Ser Arg Asp Arg Gly
            580     


<210> 905
<211> 379
<212> PRT
<213> Homo sapiens

<400> 905
Met Gly Asp Ser Arg Arg Arg Ser Leu Gly Asn Gln Pro Ser Ser Glu
 1               5                  10                  15      
Ala Ala Gly Arg Ser Glu Arg Glu Gln Asp Gly Asp Pro Arg Gly Leu
            20                  25                  30          
Gln Ser Ser Val Tyr Glu Ser Arg Arg Val Thr Asp Pro Glu Arg Gln
        35                  40                  45              
Asp Leu Asp Asn Ala Glu Leu Gly Pro Glu Asp Pro Glu Glu Glu Leu
    50                  55                  60                  
Pro Pro Glu Glu Val Ala Gly Glu Glu Phe Pro Glu Thr Leu Asp Pro
65                  70                  75                  80  
Lys Glu Ala Leu Ser Glu Leu Glu Arg Val Leu Asp Lys Asp Leu Glu
                85                  90                  95      
Glu Asp Ile Pro Glu Ile Ser Arg Leu Ser Ile Ser Gln Lys Leu Pro
            100                 105                 110         
Ser Thr Thr Met Thr Lys Ala Arg Lys Arg Arg Arg Arg Arg Arg Leu
        115                 120                 125             
Met Glu Leu Ala Glu Pro Lys Ile Asn Trp Gln Val Leu Lys Asp Arg
    130                 135                 140                 
Lys Gly Arg Cys Gly Lys Gly Tyr Ala Trp Ile Ser Pro Cys Lys Met
145                 150                 155                 160 
Ser Leu His Phe Cys Leu Cys Trp Pro Ser Val Tyr Trp Thr Glu Arg
                165                 170                 175     
Phe Leu Glu Asp Thr Thr Leu Thr Ile Thr Val Pro Ala Val Ser Arg
            180                 185                 190         
Arg Val Glu Glu Leu Ser Arg Pro Lys Arg Phe Tyr Leu Glu Tyr Tyr
        195                 200                 205             
Asn Asn Asn Arg Thr Thr Pro Val Trp Pro Ile Pro Arg Ser Ser Leu
    210                 215                 220                 
Glu Tyr Arg Ala Ser Ser Arg Leu Lys Glu Leu Ala Ala Pro Lys Ile
225                 230                 235                 240 
Arg Asp Asn Phe Trp Ser Met Pro Met Ser Glu Val Ser Gln Val Ser
                245                 250                 255     
Arg Ala Ala Gln Met Ala Val Pro Ser Ser Arg Ile Leu Gln Leu Ser
            260                 265                 270         
Lys Pro Lys Ala Pro Ala Thr Leu Leu Glu Glu Trp Asp Pro Val Pro
        275                 280                 285             
Lys Pro Lys Pro His Val Ser Asp His Asn Arg Leu Leu His Leu Ala
    290                 295                 300                 
Arg Pro Lys Ala Gln Ser Asp Lys Cys Val Pro Asp Arg Asp Pro Arg
305                 310                 315                 320 
Trp Glu Val Leu Asp Val Thr Lys Lys Val Val Ala Ser Pro Arg Ile
                325                 330                 335     
Ile Ser Leu Ala Lys Pro Lys Val Arg Lys Gly Leu Asn Glu Gly Tyr
            340                 345                 350         
Asp Arg Arg Pro Leu Ala Ser Met Ser Leu Pro Pro Pro Lys Ala Ser
        355                 360                 365             
Pro Glu Lys Cys Asp Gln Pro Arg Pro Gly Leu
    370                 375                 


<210> 906
<211> 516
<212> PRT
<213> Homo sapiens

<400> 906
Met Ala Ser Asp Pro Ile Phe Thr Leu Ala Pro Pro Leu His Cys His
 1               5                  10                  15      
Tyr Gly Ala Leu Pro Pro Asn Ala Ser Gly Trp Glu Gln Pro Pro Asn
            20                  25                  30          
Ser Ser Gly Val Ser Val Ala Gly Ala Ala Leu Ala Ala Ser Ala Ala
        35                  40                  45              
Ser Arg Val Val Thr Ser Thr Asp Pro Ser Cys Ser Gly Phe Ala Pro
    50                  55                  60                  
Pro Asp Phe Asn His Cys Leu Lys Asp Trp Asp Tyr Asn Gly Leu Pro
65                  70                  75                  80  
Val Leu Thr Thr Asn Ala Ile Gly Gln Trp Asp Leu Val Cys Asp Leu
                85                  90                  95      
Gly Trp Gln Val Ile Leu Glu Gln Ile Leu Phe Ile Leu Gly Phe Ala
            100                 105                 110         
Ser Gly Tyr Leu Phe Leu Gly Tyr Pro Ala Asp Arg Phe Gly Arg Arg
        115                 120                 125             
Gly Ile Val Leu Leu Thr Leu Gly Leu Val Gly Pro Cys Gly Val Gly
    130                 135                 140                 
Gly Ala Ala Ala Gly Ser Ser Thr Gly Ile Met Thr Leu Arg Phe Leu
145                 150                 155                 160 
Leu Gly Phe Leu Leu Ala Gly Val Asp Leu Gly Val Tyr Leu Met Arg
                165                 170                 175     
Leu Glu Leu Cys Asp Pro Thr Gln Arg Leu Arg Val Ala Leu Ala Gly
            180                 185                 190         
Glu Leu Val Gly Val Gly Gly His Phe Leu Phe Leu Gly Leu Ala Leu
        195                 200                 205             
Val Ser Lys Asp Trp Arg Phe Leu Gln Arg Met Ile Thr Ala Pro Cys
    210                 215                 220                 
Ile Leu Phe Leu Phe Tyr Gly Trp Pro Gly Leu Phe Leu Glu Ser Ala
225                 230                 235                 240 
Arg Trp Leu Ile Val Lys Arg Gln Ile Glu Glu Ala Gln Ser Val Leu
                245                 250                 255     
Arg Ile Leu Ala Glu Arg Asn Arg Pro His Gly Gln Met Leu Gly Glu
            260                 265                 270         
Glu Ala Gln Glu Ala Leu Gln Glu Leu Glu Asn Thr Cys Pro Leu Pro
        275                 280                 285             
Thr Thr Ser Thr Phe Ser Phe Ala Ser Leu Leu Asn Tyr Arg Asn Ile
    290                 295                 300                 
Trp Lys Asn Leu Leu Ile Leu Gly Phe Thr Asn Phe Ile Ala His Ala
305                 310                 315                 320 
Ile Arg His Cys Tyr Gln Pro Val Gly Gly Gly Gly Ser Pro Ser Asp
                325                 330                 335     
Phe Tyr Leu Cys Ser Leu Leu Ala Ser Gly Thr Ala Ala Leu Ala Cys
            340                 345                 350         
Val Phe Leu Gly Val Thr Val Asp Arg Phe Gly Arg Arg Gly Ile Leu
        355                 360                 365             
Leu Leu Ser Met Thr Leu Thr Gly Ile Ala Ser Leu Val Leu Leu Gly
    370                 375                 380                 
Leu Trp Asp Tyr Leu Asn Asp Ala Ala Ile Thr Thr Phe Ser Val Leu
385                 390                 395                 400 
Gly Leu Phe Ser Ser Gln Ala Ser Ala Ile Leu Ser Thr Leu Leu Ala
                405                 410                 415     
Ala Glu Val Ile Pro Thr Thr Val Arg Gly Arg Gly Leu Gly Leu Ile
            420                 425                 430         
Met Ala Leu Gly Ala Leu Gly Gly Leu Ser Cys Pro Ala Gln Arg Leu
        435                 440                 445             
His Met Gly His Gly Ala Phe Leu Gln His Val Val Leu Ala Ala Cys
    450                 455                 460                 
Ala Leu Leu Cys Ile Leu Ser Ile Met Leu Leu Pro Glu Thr Lys Arg
465                 470                 475                 480 
Lys Leu Leu Pro Glu Val Leu Arg Asp Gly Glu Leu Cys Arg Arg Pro
                485                 490                 495     
Ser Leu Leu Arg Gln Pro Pro Pro Asn Arg Cys Asp His Val Pro Leu
            500                 505                 510         
Leu Ala Thr Ser
        515     


<210> 907
<211> 588
<212> PRT
<213> Homo sapiens

<400> 907
Met Ala Ser Lys Lys Arg Glu Val Gln Leu Gln Thr Val Ile Asn Asn
 1               5                  10                  15      
Gln Ser Leu Trp Asp Glu Met Leu Gln Asn Lys Gly Leu Thr Val Ile
            20                  25                  30          
Asp Val Tyr Gln Ala Trp Cys Gly Pro Cys Arg Ala Met Gln Pro Leu
        35                  40                  45              
Phe Arg Lys Leu Lys Asn Glu Leu Asn Glu Asp Glu Ile Leu His Phe
    50                  55                  60                  
Ala Val Ala Glu Ala Asp Asn Ile Val Thr Leu Gln Pro Phe Arg Asp
65                  70                  75                  80  
Lys Cys Glu Pro Val Phe Leu Phe Ser Val Asn Gly Lys Ile Ile Glu
                85                  90                  95      
Lys Ile Gln Gly Ala Asn Ala Pro Leu Val Asn Lys Lys Val Ile Asn
            100                 105                 110         
Leu Ile Asp Glu Glu Arg Lys Ile Ala Ala Gly Glu Met Ala Arg Pro
        115                 120                 125             
Gln Tyr Pro Glu Ile Pro Leu Val Asp Ser Asp Ser Glu Val Ser Glu
    130                 135                 140                 
Glu Ser Pro Cys Glu Ser Val Gln Glu Leu Tyr Ser Ile Ala Ile Ile
145                 150                 155                 160 
Lys Pro Asp Ala Val Ile Ser Lys Lys Val Leu Glu Ile Lys Arg Lys
                165                 170                 175     
Ile Thr Lys Ala Gly Phe Ile Ile Glu Ala Glu His Lys Thr Val Leu
            180                 185                 190         
Thr Glu Glu Gln Val Val Asn Phe Tyr Ser Arg Ile Ala Asp Gln Cys
        195                 200                 205             
Asp Phe Glu Glu Phe Val Ser Phe Met Thr Ser Gly Leu Ser Tyr Ile
    210                 215                 220                 
Leu Val Val Ser Gln Gly Ser Lys His Asn Pro Pro Ser Glu Glu Thr
225                 230                 235                 240 
Glu Pro Gln Thr Asp Thr Glu Pro Asn Glu Arg Ser Glu Asp Gln Pro
                245                 250                 255     
Glu Val Glu Ala Gln Val Thr Pro Gly Met Met Lys Asn Lys Gln Asp
            260                 265                 270         
Ser Leu Gln Glu Tyr Leu Glu Arg Gln His Leu Ala Gln Leu Cys Asp
        275                 280                 285             
Ile Glu Glu Asp Ala Ala Asn Val Ala Lys Phe Met Asp Ala Phe Phe
    290                 295                 300                 
Pro Asp Phe Lys Lys Met Lys Ser Met Lys Leu Glu Lys Thr Leu Ala
305                 310                 315                 320 
Leu Leu Arg Pro Asn Leu Phe His Glu Arg Lys Asp Asp Val Leu Arg
                325                 330                 335     
Ile Ile Lys Asp Glu Asp Phe Lys Ile Leu Glu Gln Arg Gln Val Val
            340                 345                 350         
Leu Ser Glu Lys Glu Ala Gln Ala Leu Cys Lys Glu Tyr Glu Asn Glu
        355                 360                 365             
Asp Tyr Phe Asn Lys Leu Ile Glu Asn Met Thr Ser Gly Pro Ser Leu
    370                 375                 380                 
Ala Leu Val Leu Leu Arg Asp Asn Gly Leu Gln Tyr Trp Lys Gln Leu
385                 390                 395                 400 
Leu Gly Pro Arg Thr Val Glu Glu Ala Ile Glu Tyr Phe Pro Glu Ser
                405                 410                 415     
Leu Cys Ala Gln Phe Ala Met Asp Ser Leu Pro Val Asn Gln Leu Tyr
            420                 425                 430         
Gly Ser Asp Ser Leu Glu Thr Ala Glu Arg Glu Ile Gln His Phe Phe
        435                 440                 445             
Pro Leu Gln Ser Thr Leu Gly Leu Ile Lys Pro His Ala Thr Ser Glu
    450                 455                 460                 
Gln Arg Glu Gln Ile Leu Lys Ile Val Lys Glu Ala Gly Phe Asp Leu
465                 470                 475                 480 
Thr Gln Val Lys Lys Met Phe Leu Thr Pro Glu Gln Ile Glu Lys Ile
                485                 490                 495     
Tyr Pro Lys Val Thr Gly Lys Asp Phe Tyr Lys Asp Leu Leu Glu Met
            500                 505                 510         
Leu Ser Val Gly Pro Ser Met Val Met Ile Leu Thr Lys Trp Asn Ala
        515                 520                 525             
Val Ala Glu Trp Arg Arg Leu Met Gly Pro Thr Asp Pro Glu Glu Ala
    530                 535                 540                 
Lys Leu Leu Ser Pro Asp Ser Ile Arg Ala Gln Phe Gly Ile Ser Lys
545                 550                 555                 560 
Leu Lys Asn Ile Val His Gly Ala Ser Asn Ala Tyr Glu Ala Lys Glu
                565                 570                 575     
Val Val Asn Arg Leu Phe Glu Asp Pro Glu Glu Asn
            580                 585             


<210> 908
<211> 289
<212> PRT
<213> Homo sapiens

<400> 908
Met Glu Ala Val Leu Thr Glu Glu Leu Asp Glu Glu Glu Gln Leu Leu
 1               5                  10                  15      
Arg Arg His Arg Lys Glu Lys Lys Glu Leu Gln Ala Lys Ile Gln Gly
            20                  25                  30          
Met Lys Asn Ala Val Pro Lys Asn Asp Lys Lys Arg Arg Lys Gln Leu
        35                  40                  45              
Thr Glu Asp Val Ala Lys Leu Glu Lys Glu Met Glu Gln Lys His Arg
    50                  55                  60                  
Glu Glu Leu Glu Gln Leu Lys Leu Thr Thr Lys Glu Asn Lys Ile Asp
65                  70                  75                  80  
Ser Val Ala Val Asn Ile Ser Asn Leu Val Leu Glu Asn Gln Pro Pro
                85                  90                  95      
Arg Ile Ser Lys Ala Gln Lys Arg Arg Glu Lys Lys Ala Ala Leu Glu
            100                 105                 110         
Lys Glu Arg Glu Glu Arg Ile Ala Glu Ala Glu Ile Glu Asn Leu Thr
        115                 120                 125             
Gly Ala Arg His Met Glu Ser Glu Lys Leu Ala Gln Ile Leu Ala Ala
    130                 135                 140                 
Arg Gln Leu Glu Ile Lys Gln Ile Pro Ser Asp Gly His Cys Met Tyr
145                 150                 155                 160 
Lys Ala Ile Glu Asp Gln Leu Lys Glu Lys Asp Cys Ala Leu Thr Val
                165                 170                 175     
Val Ala Leu Arg Ser Gln Thr Ala Glu Tyr Met Gln Ser His Val Glu
            180                 185                 190         
Asp Phe Leu Pro Phe Leu Thr Asn Pro Asn Thr Gly Asp Met Tyr Thr
        195                 200                 205             
Pro Glu Glu Phe Gln Lys Tyr Cys Glu Asp Ile Val Asn Thr Ala Ala
    210                 215                 220                 
Trp Gly Gly Gln Leu Glu Leu Arg Ala Leu Ser His Ile Leu Gln Thr
225                 230                 235                 240 
Pro Ile Glu Ile Ile Gln Ala Asp Ser Pro Pro Ile Ile Val Gly Glu
                245                 250                 255     
Glu Tyr Ser Lys Lys Pro Leu Ile Leu Val Tyr Met Arg His Ala Tyr
            260                 265                 270         
Gly Leu Gly Glu His Tyr Asn Ser Val Thr Arg Leu Gly Lys His Ser
        275                 280                 285             
Tyr
    


<210> 909
<211> 106
<212> PRT
<213> Homo sapiens

<400> 909
Met Ser Ser Leu Ser Glu Tyr Ala Phe Arg Met Ser Arg Leu Ser Ala
 1               5                  10                  15      
Arg Leu Phe Gly Glu Val Thr Arg Pro Thr Asn Ser Lys Ser Met Lys
            20                  25                  30          
Val Val Lys Leu Phe Ser Glu Leu Pro Leu Ala Lys Lys Lys Glu Thr
        35                  40                  45              
Tyr Asp Trp Tyr Pro Asn His His Thr Tyr Ala Glu Leu Met Gln Thr
    50                  55                  60                  
Leu Arg Phe Leu Gly Leu Tyr Arg Asp Glu His Gln Asp Phe Met Asp
65                  70                  75                  80  
Glu Gln Lys Arg Leu Lys Lys Leu Arg Gly Lys Glu Lys Pro Lys Lys
                85                  90                  95      
Gly Glu Gly Lys Arg Ala Ala Lys Arg Lys
            100                 105     


<210> 910
<211> 683
<212> PRT
<213> Homo sapiens

<400> 910
Met Leu Phe Ile Phe Asn Phe Leu Phe Ser Pro Leu Pro Thr Pro Ala
 1               5                  10                  15      
Leu Ile Cys Ile Leu Thr Phe Gly Ala Ala Ile Phe Leu Trp Leu Ile
            20                  25                  30          
Thr Arg Pro Gln Pro Val Leu Pro Leu Leu Asp Leu Asn Asn Gln Ser
        35                  40                  45              
Val Gly Ile Glu Gly Gly Ala Arg Lys Gly Val Ser Gln Lys Asn Asn
    50                  55                  60                  
Asp Leu Thr Ser Cys Cys Phe Ser Asp Ala Lys Thr Met Tyr Glu Val
65                  70                  75                  80  
Phe Gln Arg Gly Leu Ala Val Ser Asp Asn Gly Pro Cys Leu Gly Tyr
                85                  90                  95      
Arg Lys Pro Asn Gln Pro Tyr Arg Trp Leu Ser Tyr Lys Gln Val Ser
            100                 105                 110         
Asp Arg Ala Glu Tyr Leu Gly Ser Cys Leu Leu His Lys Gly Tyr Lys
        115                 120                 125             
Ser Ser Pro Asp Gln Phe Val Gly Ile Phe Ala Gln Asn Arg Pro Glu
    130                 135                 140                 
Trp Ile Ile Ser Glu Leu Ala Cys Tyr Thr Tyr Ser Met Val Ala Val
145                 150                 155                 160 
Pro Leu Tyr Asp Thr Leu Gly Pro Glu Ala Ile Val His Ile Val Asn
                165                 170                 175     
Lys Ala Asp Ile Ala Met Val Ile Cys Asp Thr Pro Gln Lys Ala Leu
            180                 185                 190         
Val Leu Ile Gly Asn Val Glu Lys Gly Phe Thr Pro Ser Leu Lys Val
        195                 200                 205             
Ile Ile Leu Met Asp Pro Phe Asp Asp Asp Leu Lys Gln Arg Gly Glu
    210                 215                 220                 
Lys Ser Gly Ile Glu Ile Leu Ser Leu Tyr Asp Ala Glu Asn Leu Gly
225                 230                 235                 240 
Lys Glu His Phe Arg Lys Pro Val Pro Pro Ser Pro Glu Asp Leu Ser
                245                 250                 255     
Val Ile Cys Phe Thr Ser Gly Thr Thr Gly Asp Pro Lys Gly Ala Met
            260                 265                 270         
Ile Thr His Gln Asn Ile Val Ser Asn Ala Ala Ala Phe Leu Lys Cys
        275                 280                 285             
Val Glu His Ala Tyr Glu Pro Thr Pro Asp Asp Val Ala Ile Ser Tyr
    290                 295                 300                 
Leu Pro Leu Ala His Met Phe Glu Arg Ile Val Gln Ala Val Val Tyr
305                 310                 315                 320 
Ser Cys Gly Ala Arg Val Gly Phe Phe Gln Gly Asp Ile Arg Leu Leu
                325                 330                 335     
Ala Asp Asp Met Lys Thr Leu Lys Pro Thr Leu Phe Pro Ala Val Pro
            340                 345                 350         
Arg Leu Leu Asn Arg Ile Tyr Asp Lys Val Gln Asn Glu Ala Lys Thr
        355                 360                 365             
Pro Leu Lys Lys Phe Leu Leu Lys Leu Ala Val Ser Ser Lys Phe Lys
    370                 375                 380                 
Glu Leu Gln Lys Gly Ile Ile Arg His Asp Ser Phe Trp Asp Lys Leu
385                 390                 395                 400 
Ile Phe Ala Lys Ile Gln Asp Ser Leu Gly Gly Arg Val Arg Val Ile
                405                 410                 415     
Val Thr Gly Ala Ala Pro Met Ser Thr Ser Val Met Thr Phe Phe Arg
            420                 425                 430         
Ala Ala Met Gly Cys Gln Val Tyr Glu Ala Tyr Gly Gln Thr Glu Cys
        435                 440                 445             
Thr Gly Gly Cys Thr Phe Thr Leu Pro Gly Asp Trp Thr Ser Gly His
    450                 455                 460                 
Val Gly Val Pro Leu Ala Cys Asn Tyr Val Lys Leu Glu Asp Val Ala
465                 470                 475                 480 
Asp Met Asn Tyr Phe Thr Val Asn Asn Glu Gly Glu Val Cys Ile Lys
                485                 490                 495     
Gly Thr Asn Val Phe Lys Gly Tyr Leu Lys Asp Pro Glu Lys Thr Gln
            500                 505                 510         
Glu Ala Leu Asp Ser Asp Gly Trp Leu His Thr Gly Asp Ile Gly Arg
        515                 520                 525             
Trp Leu Pro Asn Gly Thr Leu Lys Ile Ile Asp Arg Lys Lys Asn Ile
    530                 535                 540                 
Phe Lys Leu Ala Gln Gly Glu Tyr Ile Ala Pro Glu Lys Ile Glu Asn
545                 550                 555                 560 
Ile Tyr Asn Arg Ser Gln Pro Val Leu Gln Ile Phe Val His Gly Glu
                565                 570                 575     
Ser Leu Arg Ser Ser Leu Val Gly Val Val Val Pro Asp Thr Asp Val
            580                 585                 590         
Leu Pro Ser Phe Ala Ala Lys Leu Gly Val Lys Gly Ser Phe Glu Glu
        595                 600                 605             
Leu Cys Gln Asn Gln Val Val Arg Glu Ala Ile Leu Glu Asp Leu Gln
    610                 615                 620                 
Lys Ile Gly Lys Glu Ser Gly Leu Lys Thr Phe Glu Gln Val Lys Ala
625                 630                 635                 640 
Ile Phe Leu His Pro Glu Pro Phe Ser Ile Glu Asn Gly Leu Leu Thr
                645                 650                 655     
Pro Thr Leu Lys Ala Lys Arg Gly Glu Leu Ser Lys Tyr Phe Arg Thr
            660                 665                 670         
Gln Ile Asp Ser Leu Tyr Glu His Ile Gln Asp
        675                 680             


<210> 911
<211> 341
<212> PRT
<213> Homo sapiens

<400> 911
Met Pro Phe Pro Phe Gly Lys Ser His Lys Ser Pro Ala Asp Ile Val
 1               5                  10                  15      
Lys Asn Leu Lys Glu Ser Met Ala Val Leu Glu Lys Gln Asp Ile Ser
            20                  25                  30          
Asp Lys Lys Ala Glu Lys Ala Thr Glu Glu Val Ser Lys Asn Leu Val
        35                  40                  45              
Ala Met Lys Glu Ile Leu Tyr Gly Thr Asn Glu Lys Glu Pro Gln Thr
    50                  55                  60                  
Glu Ala Val Ala Gln Leu Ala Gln Glu Leu Tyr Asn Ser Gly Leu Leu
65                  70                  75                  80  
Ser Thr Leu Val Ala Asp Leu Gln Leu Ile Asp Phe Glu Gly Lys Lys
                85                  90                  95      
Asp Val Ala Gln Ile Phe Asn Asn Ile Leu Arg Arg Gln Ile Gly Thr
            100                 105                 110         
Arg Thr Pro Thr Val Glu Tyr Ile Cys Thr Gln Gln Asn Ile Leu Phe
        115                 120                 125             
Met Leu Leu Lys Gly Tyr Glu Ser Pro Glu Ile Ala Leu Asn Cys Gly
    130                 135                 140                 
Ile Met Leu Arg Glu Cys Ile Arg His Glu Pro Leu Ala Lys Ile Ile
145                 150                 155                 160 
Leu Trp Ser Glu Gln Phe Tyr Asp Phe Phe Arg Tyr Val Glu Met Ser
                165                 170                 175     
Thr Phe Asp Ile Ala Ser Asp Ala Phe Ala Thr Phe Lys Asp Leu Leu
            180                 185                 190         
Thr Arg His Lys Leu Leu Ser Ala Glu Phe Leu Glu Gln His Tyr Asp
        195                 200                 205             
Arg Phe Phe Ser Glu Tyr Glu Lys Leu Leu His Ser Glu Asn Tyr Val
    210                 215                 220                 
Thr Lys Arg Gln Ser Leu Lys Leu Leu Gly Glu Leu Leu Leu Asp Arg
225                 230                 235                 240 
His Asn Phe Thr Ile Met Thr Lys Tyr Ile Ser Lys Pro Glu Asn Leu
                245                 250                 255     
Lys Leu Met Met Asn Leu Leu Arg Asp Lys Ser Arg Asn Ile Gln Phe
            260                 265                 270         
Glu Ala Phe His Val Phe Lys Val Phe Val Ala Asn Pro Asn Lys Thr
        275                 280                 285             
Gln Pro Ile Leu Asp Ile Leu Leu Lys Asn Gln Ala Lys Leu Ile Glu
    290                 295                 300                 
Phe Leu Ser Lys Phe Gln Asn Asp Arg Thr Glu Asp Glu Gln Phe Asn
305                 310                 315                 320 
Asp Glu Lys Thr Tyr Leu Val Lys Gln Ile Arg Asp Leu Lys Arg Pro
                325                 330                 335     
Ala Gln Gln Glu Ala
            340     


<210> 912
<211> 1490
<212> PRT
<213> Homo sapiens

<400> 912
Met Pro Asn Ser Glu Arg His Gly Gly Lys Lys Asp Gly Ser Gly Gly
 1               5                  10                  15      
Ala Ser Gly Thr Leu Gln Pro Ser Ser Gly Gly Gly Ser Ser Asn Ser
            20                  25                  30          
Arg Glu Arg His Arg Leu Val Ser Lys His Lys Arg His Lys Ser Lys
        35                  40                  45              
His Ser Lys Asp Met Gly Leu Val Thr Pro Glu Ala Ala Ser Leu Gly
    50                  55                  60                  
Thr Val Ile Lys Pro Leu Val Glu Tyr Asp Asp Ile Ser Ser Asp Ser
65                  70                  75                  80  
Asp Thr Phe Ser Asp Asp Met Ala Phe Lys Leu Asp Arg Arg Glu Asn
                85                  90                  95      
Asp Glu Arg Arg Gly Ser Asp Arg Ser Asp Arg Leu His Lys His Arg
            100                 105                 110         
His His Gln His Arg Arg Ser Arg Asp Leu Leu Lys Ala Lys Gln Thr
        115                 120                 125             
Glu Lys Glu Lys Ser Gln Glu Val Ser Ser Lys Ser Gly Ser Met Lys
    130                 135                 140                 
Asp Arg Ile Ser Gly Ser Ser Lys Arg Ser Asn Glu Glu Thr Asp Asp
145                 150                 155                 160 
Tyr Gly Lys Ala Gln Val Ala Lys Ser Ser Ser Lys Glu Ser Arg Ser
                165                 170                 175     
Ser Lys Leu His Lys Glu Lys Thr Arg Lys Glu Arg Glu Leu Lys Ser
            180                 185                 190         
Gly His Lys Asp Arg Ser Lys Ser His Arg Lys Arg Glu Thr Pro Lys
        195                 200                 205             
Ser Tyr Lys Thr Val Asp Ser Pro Lys Arg Arg Ser Arg Ser Pro His
    210                 215                 220                 
Arg Lys Trp Ser Asp Ser Ser Lys Gln Asp Asp Ser Pro Ser Gly Ala
225                 230                 235                 240 
Ser Tyr Gly Gln Asp Tyr Asp Leu Ser Pro Ser Arg Ser His Thr Ser
                245                 250                 255     
Ser Asn Tyr Asp Ser Tyr Lys Lys Ser Pro Gly Ser Thr Ser Arg Arg
            260                 265                 270         
Gln Ser Val Ser Pro Pro Tyr Lys Glu Pro Ser Ala Tyr Gln Ser Ser
        275                 280                 285             
Thr Arg Ser Pro Ser Pro Tyr Ser Arg Arg Gln Arg Ser Val Ser Pro
    290                 295                 300                 
Tyr Ser Arg Arg Arg Ser Ser Ser Tyr Glu Arg Ser Gly Ser Tyr Ser
305                 310                 315                 320 
Gly Arg Ser Pro Ser Pro Tyr Gly Arg Arg Arg Ser Ser Ser Pro Phe
                325                 330                 335     
Leu Ser Lys Arg Ser Leu Ser Arg Ser Pro Leu Pro Ser Arg Lys Ser
            340                 345                 350         
Met Lys Ser Arg Ser Arg Ser Pro Ala Tyr Ser Arg His Ser Ser Ser
        355                 360                 365             
His Ser Lys Lys Lys Arg Ser Ser Ser Arg Ser Arg His Ser Ser Ile
    370                 375                 380                 
Ser Pro Val Arg Leu Pro Leu Asn Ser Ser Leu Gly Ala Glu Leu Ser
385                 390                 395                 400 
Arg Lys Lys Lys Glu Arg Ala Ala Ala Ala Ala Ala Ala Lys Met Asp
                405                 410                 415     
Gly Lys Glu Ser Lys Gly Ser Pro Val Phe Leu Pro Arg Lys Glu Asn
            420                 425                 430         
Ser Ser Val Glu Ala Lys Asp Ser Gly Leu Glu Ser Lys Lys Leu Pro
        435                 440                 445             
Arg Ser Val Lys Leu Glu Lys Ser Ala Pro Asp Thr Glu Leu Val Asn
    450                 455                 460                 
Val Thr His Leu Asn Thr Glu Val Lys Asn Ser Ser Asp Thr Gly Lys
465                 470                 475                 480 
Val Lys Leu Asp Glu Asn Ser Glu Lys His Leu Val Lys Asp Leu Lys
                485                 490                 495     
Ala Gln Gly Thr Arg Asp Ser Lys Pro Ile Ala Leu Lys Glu Glu Ile
            500                 505                 510         
Val Thr Pro Lys Glu Thr Glu Thr Ser Glu Lys Glu Thr Pro Pro Pro
        515                 520                 525             
Leu Pro Thr Ile Ala Ser Pro Pro Pro Pro Leu Pro Thr Thr Thr Pro
    530                 535                 540                 
Pro Pro Gln Thr Pro Pro Leu Pro Pro Leu Pro Pro Ile Pro Ala Leu
545                 550                 555                 560 
Pro Gln Gln Pro Pro Leu Pro Pro Ser Gln Pro Ala Phe Ser Gln Val
                565                 570                 575     
Pro Ala Ser Ser Thr Ser Thr Leu Pro Pro Ser Thr His Ser Lys Thr
            580                 585                 590         
Ser Ala Val Ser Ser Gln Ala Asn Ser Gln Pro Pro Val Gln Val Ser
        595                 600                 605             
Val Lys Thr Gln Val Ser Val Thr Ala Ala Ile Pro His Leu Lys Thr
    610                 615                 620                 
Ser Thr Leu Pro Pro Leu Pro Leu Pro Pro Leu Leu Pro Gly Gly Asp
625                 630                 635                 640 
Asp Met Asp Ser Pro Lys Glu Thr Leu Pro Ser Lys Pro Val Lys Lys
                645                 650                 655     
Glu Lys Glu Gln Arg Thr Arg His Leu Leu Thr Asp Leu Pro Leu Pro
            660                 665                 670         
Pro Glu Leu Pro Gly Gly Asp Leu Ser Pro Pro Asp Ser Pro Glu Pro
        675                 680                 685             
Lys Ala Ile Thr Pro Pro Gln Gln Pro Tyr Lys Lys Arg Pro Lys Ile
    690                 695                 700                 
Cys Cys Pro Arg Tyr Gly Glu Arg Arg Gln Thr Glu Ser Asp Trp Gly
705                 710                 715                 720 
Lys Arg Cys Val Asp Lys Phe Asp Ile Ile Gly Ile Ile Gly Glu Gly
                725                 730                 735     
Thr Tyr Gly Gln Val Tyr Lys Ala Arg Asp Lys Asp Thr Gly Glu Leu
            740                 745                 750         
Val Ala Leu Lys Lys Val Arg Leu Asp Asn Glu Lys Glu Gly Phe Pro
        755                 760                 765             
Ile Thr Ala Ile Arg Glu Ile Lys Ile Leu Arg Gln Leu Ile His Arg
    770                 775                 780                 
Ser Val Val Asn Met Lys Glu Ile Val Thr Asp Lys Gln Asp Ala Leu
785                 790                 795                 800 
Asp Phe Lys Lys Asp Lys Gly Ala Phe Tyr Leu Val Phe Glu Tyr Met
                805                 810                 815     
Asp His Asp Leu Met Gly Leu Leu Glu Ser Gly Leu Val His Phe Ser
            820                 825                 830         
Glu Asp His Ile Lys Ser Phe Met Lys Gln Leu Met Glu Gly Leu Glu
        835                 840                 845             
Tyr Cys His Lys Lys Asn Phe Leu His Arg Asp Ile Lys Cys Ser Asn
    850                 855                 860                 
Ile Leu Leu Asn Asn Ser Gly Gln Ile Lys Leu Ala Asp Phe Gly Leu
865                 870                 875                 880 
Ala Arg Leu Tyr Asn Ser Glu Glu Ser Arg Pro Tyr Thr Asn Lys Val
                885                 890                 895     
Ile Thr Leu Trp Tyr Arg Pro Pro Glu Leu Leu Leu Gly Glu Glu Arg
            900                 905                 910         
Tyr Thr Pro Ala Ile Asp Val Trp Ser Cys Gly Cys Ile Leu Gly Glu
        915                 920                 925             
Leu Phe Thr Lys Lys Pro Ile Phe Gln Ala Asn Leu Glu Leu Ala Gln
    930                 935                 940                 
Leu Glu Leu Ile Ser Arg Leu Cys Gly Ser Pro Cys Pro Ala Val Trp
945                 950                 955                 960 
Pro Asp Val Ile Lys Leu Pro Tyr Phe Asn Thr Met Lys Pro Lys Lys
                965                 970                 975     
Gln Tyr Arg Arg Arg Leu Arg Glu Glu Phe Ser Phe Ile Pro Ser Ala
            980                 985                 990         
Ala Leu Asp Leu Leu Asp His Met Leu Thr Leu Asp Pro Ser Lys Arg
        995                 1000                1005            
Cys Thr Ala Glu Gln Thr Leu Gln Ser Asp Phe Leu Lys Asp Val Glu
    1010                1015                1020                
Leu Ser Lys Met Ala Pro Pro Asp Leu Pro His Trp Gln Asp Cys His
1025                1030                1035                1040
Glu Leu Trp Ser Lys Lys Arg Arg Arg Gln Arg Gln Ser Gly Val Val
                1045                1050                1055    
Val Glu Glu Pro Pro Pro Ser Lys Thr Ser Arg Lys Glu Thr Thr Ser
            1060                1065                1070        
Gly Thr Ser Thr Glu Pro Val Lys Asn Ser Ser Pro Ala Pro Pro Gln
        1075                1080                1085            
Pro Ala Pro Gly Lys Val Glu Ser Gly Ala Gly Asp Ala Ile Gly Leu
    1090                1095                1100                
Ala Asp Ile Thr Gln Gln Leu Asn Gln Ser Glu Leu Ala Val Leu Leu
1105                1110                1115                1120
Asn Leu Leu Gln Ser Gln Thr Asp Leu Ser Ile Pro Gln Met Ala Gln
                1125                1130                1135    
Leu Leu Asn Ile His Ser Asn Pro Glu Met Gln Gln Gln Leu Glu Ala
            1140                1145                1150        
Leu Asn Gln Ser Ile Ser Ala Leu Thr Glu Ala Thr Ser Gln Gln Gln
        1155                1160                1165            
Asp Ser Glu Thr Met Ala Pro Glu Glu Ser Leu Lys Glu Ala Pro Ser
    1170                1175                1180                
Ala Pro Val Ile Leu Pro Ser Ala Glu Gln Met Thr Leu Glu Ala Ser
1185                1190                1195                1200
Ser Thr Pro Ala Asp Met Gln Asn Ile Leu Ala Val Leu Leu Ser Gln
                1205                1210                1215    
Leu Met Lys Thr Gln Glu Pro Ala Gly Ser Leu Glu Glu Asn Asn Ser
            1220                1225                1230        
Asp Lys Asn Ser Gly Pro Gln Gly Pro Arg Arg Thr Pro Thr Met Pro
        1235                1240                1245            
Gln Glu Glu Ala Ala Ala Cys Pro Pro His Ile Leu Pro Pro Glu Lys
    1250                1255                1260                
Arg Pro Pro Glu Pro Pro Gly Pro Pro Pro Pro Pro Pro Pro Pro Pro
1265                1270                1275                1280
Leu Val Glu Gly Asp Leu Ser Ser Ala Pro Gln Glu Leu Asn Pro Ala
                1285                1290                1295    
Val Thr Ala Ala Leu Leu Gln Leu Leu Ser Gln Pro Glu Ala Glu Pro
            1300                1305                1310        
Pro Gly His Leu Pro His Glu His Gln Ala Leu Arg Pro Met Glu Tyr
        1315                1320                1325            
Ser Thr Arg Pro Arg Pro Asn Arg Thr Tyr Gly Asn Thr Asp Gly Pro
    1330                1335                1340                
Glu Thr Gly Phe Ser Ala Ile Asp Thr Asp Glu Arg Asn Ser Gly Pro
1345                1350                1355                1360
Ala Leu Thr Glu Ser Leu Val Gln Thr Leu Val Lys Asn Arg Thr Phe
                1365                1370                1375    
Ser Gly Ser Leu Ser His Leu Gly Glu Ser Ser Ser Tyr Gln Gly Thr
            1380                1385                1390        
Gly Ser Val Gln Phe Pro Gly Asp Gln Asp Leu Arg Phe Ala Arg Val
        1395                1400                1405            
Pro Leu Ala Leu His Pro Val Val Gly Gln Pro Phe Leu Lys Ala Glu
    1410                1415                1420                
Gly Ser Ser Asn Ser Val Val His Ala Glu Thr Lys Leu Gln Asn Tyr
1425                1430                1435                1440
Gly Glu Leu Gly Pro Gly Thr Thr Gly Ala Ser Ser Ser Gly Ala Gly
                1445                1450                1455    
Leu His Trp Gly Gly Pro Thr Gln Ser Ser Ala Tyr Gly Lys Leu Tyr
            1460                1465                1470        
Arg Gly Pro Thr Arg Val Pro Pro Arg Gly Gly Arg Gly Arg Gly Val
        1475                1480                1485            
Pro Tyr
    1490


<210> 913
<211> 615
<212> PRT
<213> Homo sapiens

<400> 913
Met Phe Ala Arg Gly Ser Arg Arg Arg Arg Ser Gly Arg Ala Pro Pro
 1               5                  10                  15      
Glu Ala Glu Asp Pro Asp Arg Gly Gln Pro Cys Asn Ser Cys Arg Glu
            20                  25                  30          
Gln Cys Pro Gly Phe Leu Leu His Gly Trp Arg Lys Ile Cys Gln His
        35                  40                  45              
Cys Lys Cys Pro Arg Glu Glu His Ala Val His Ala Val Pro Val Asp
    50                  55                  60                  
Leu Glu Arg Ile Met Cys Arg Leu Ile Ser Asp Phe Gln Arg His Ser
65                  70                  75                  80  
Ile Ser Asp Asp Asp Ser Gly Cys Ala Ser Glu Glu Tyr Ala Trp Val
                85                  90                  95      
Pro Pro Gly Leu Lys Pro Glu Gln Val Tyr Gln Phe Phe Ser Cys Leu
            100                 105                 110         
Pro Glu Asp Lys Val Pro Tyr Val Asn Ser Pro Gly Glu Lys Tyr Arg
        115                 120                 125             
Ile Lys Gln Leu Leu His Gln Leu Pro Pro His Asp Ser Glu Ala Gln
    130                 135                 140                 
Tyr Cys Thr Ala Leu Glu Glu Glu Glu Lys Lys Glu Leu Arg Ala Phe
145                 150                 155                 160 
Ser Gln Gln Arg Lys Arg Glu Asn Leu Gly Arg Gly Ile Val Arg Ile
                165                 170                 175     
Phe Pro Val Thr Ile Thr Gly Ala Ile Cys Glu Glu Cys Gly Lys Gln
            180                 185                 190         
Ile Gly Gly Gly Asp Ile Ala Val Phe Ala Ser Arg Ala Gly Leu Gly
        195                 200                 205             
Ala Cys Trp His Pro Gln Cys Phe Val Cys Thr Thr Cys Gln Glu Leu
    210                 215                 220                 
Leu Val Asp Leu Ile Tyr Phe Tyr His Val Gly Lys Val Tyr Cys Gly
225                 230                 235                 240 
Arg His His Ala Glu Cys Leu Arg Pro Arg Cys Gln Ala Cys Asp Glu
                245                 250                 255     
Ile Ile Phe Ser Pro Glu Cys Thr Glu Ala Glu Gly Arg His Trp His
            260                 265                 270         
Met Asp His Phe Cys Cys Phe Glu Cys Glu Ala Ser Leu Gly Gly Gln
        275                 280                 285             
Arg Tyr Val Met Arg Gln Ser Arg Pro His Cys Cys Ala Cys Tyr Glu
    290                 295                 300                 
Ala Arg His Ala Glu Tyr Cys Asp Gly Cys Gly Glu His Ile Gly Leu
305                 310                 315                 320 
Asp Gln Gly Gln Met Ala Tyr Glu Gly Gln His Trp His Ala Ser Asp
                325                 330                 335     
Arg Cys Phe Cys Cys Ser Arg Cys Gly Arg Ala Leu Leu Gly Arg Pro
            340                 345                 350         
Phe Leu Pro Arg Arg Gly Leu Ile Phe Cys Ser Arg Ala Cys Ser Leu
        355                 360                 365             
Gly Ser Glu Pro Thr Ala Pro Gly Pro Ser Arg Arg Ser Trp Ser Ala
    370                 375                 380                 
Gly Pro Val Thr Ala Pro Leu Ala Ala Ser Thr Ala Ser Phe Ser Ala
385                 390                 395                 400 
Val Lys Gly Ala Ser Glu Thr Thr Thr Lys Gly Thr Ser Thr Glu Leu
                405                 410                 415     
Ala Pro Ala Thr Gly Pro Glu Glu Pro Ser Arg Phe Leu Arg Gly Ala
            420                 425                 430         
Pro His Arg His Ser Met Pro Glu Leu Gly Leu Arg Ser Val Pro Glu
        435                 440                 445             
Pro Pro Pro Glu Ser Pro Gly Gln Pro Asn Leu Arg Pro Asp Asp Ser
    450                 455                 460                 
Ala Phe Gly Arg Gln Ser Thr Pro Arg Val Ser Phe Arg Asp Pro Leu
465                 470                 475                 480 
Val Ser Glu Gly Gly Pro Arg Arg Thr Leu Ser Ala Pro Pro Ala Gln
                485                 490                 495     
Arg Arg Arg Pro Arg Ser Pro Pro Pro Arg Ala Pro Ser Arg Arg Arg
            500                 505                 510         
His His His His Asn His His His His His Asn Arg His Pro Ser Arg
        515                 520                 525             
Arg Arg His Tyr Gln Cys Asp Ala Gly Ser Gly Ser Asp Ser Glu Ser
    530                 535                 540                 
Cys Ser Ser Ser Pro Ser Ser Ser Ser Ser Glu Ser Ser Glu Asp Asp
545                 550                 555                 560 
Gly Phe Phe Leu Gly Glu Arg Ile Pro Leu Pro Pro His Leu Cys Arg
                565                 570                 575     
Pro Met Pro Ala Gln Asp Thr Ala Met Glu Thr Phe Asn Ser Pro Ser
            580                 585                 590         
Leu Ser Leu Pro Arg Asp Ser Arg Ala Gly Met Pro Arg Gln Ala Arg
        595                 600                 605             
Asp Lys Asn Cys Ile Val Ala
    610                 615 


<210> 914
<211> 100
<212> PRT
<213> Homo sapiens

<400> 914
Met Val Gly Trp Gln Glu Gly Ala Asn His Lys Asn Gly Ala Gly Arg
 1               5                  10                  15      
Ser Gln Lys Gln Glu Met Ala Glu Lys Met Val Pro Glu Val Ala Ser
            20                  25                  30          
Gly Glu Glu Ile Gly Gly Arg Ser Glu Ala Gly Arg Glu Ser Pro Asp
        35                  40                  45              
Leu Phe Arg Pro Asn Thr Val Glu Ala Arg Asp Arg Pro Ala Gly Pro
    50                  55                  60                  
Pro Phe Ser Lys Ser Ala Ser Val Arg Val Leu Gln Arg Ser Arg Thr
65                  70                  75                  80  
Asn Arg Asp Tyr Ile Pro Ile Glu His Ile Gln Ser Pro Ile Gly Ile
                85                  90                  95      
Tyr Asn Met Leu
            100 


<210> 915
<211> 210
<212> PRT
<213> Homo sapiens

<400> 915
Met Ala Lys Leu Arg Val Ala Tyr Glu Tyr Thr Glu Ala Glu Asp Lys
 1               5                  10                  15      
Ser Ile Arg Leu Gly Leu Phe Leu Ile Ile Ser Gly Val Val Ser Leu
            20                  25                  30          
Phe Ile Phe Gly Phe Cys Trp Leu Ser Pro Ala Leu Gln Asp Leu Gln
        35                  40                  45              
Ala Thr Glu Ala Asn Cys Thr Val Leu Ser Val Gln Gln Ile Gly Glu
    50                  55                  60                  
Val Phe Glu Cys Thr Phe Thr Cys Gly Ala Asp Cys Arg Gly Thr Ser
65                  70                  75                  80  
Gln Tyr Pro Cys Val Gln Val Tyr Val Asn Asn Ser Glu Ser Asn Ser
                85                  90                  95      
Arg Ala Leu Leu His Ser Asp Glu His Gln Leu Leu Thr Asn Pro Lys
            100                 105                 110         
Cys Ser Tyr Ile Pro Pro Cys Lys Arg Glu Asn Gln Lys Asn Leu Glu
        115                 120                 125             
Ser Val Met Asn Trp Gln Gln Tyr Trp Lys Asp Glu Ile Gly Ser Gln
    130                 135                 140                 
Pro Phe Thr Cys Tyr Phe Asn Gln His Gln Arg Pro Asp Asp Val Leu
145                 150                 155                 160 
Leu His Arg Thr His Asp Glu Ile Val Leu Leu His Cys Phe Leu Trp
                165                 170                 175     
Pro Leu Val Thr Phe Val Val Gly Val Leu Ile Val Val Leu Thr Ile
            180                 185                 190         
Cys Ala Lys Ser Leu Ala Ile Lys Ala Glu Ala Met Lys Lys Arg Lys
        195                 200                 205             
Phe Ser
    210 


<210> 916
<211> 84
<212> PRT
<213> Homo sapiens

<400> 916
Met Gln Lys Ser Ser Ser Thr Arg Ala Gly Asp Met Arg Glu Lys Asp
 1               5                  10                  15      
Thr Arg Gly Cys Arg Met Ser Ser Arg Ser Glu Cys Gly Asn Leu Thr
            20                  25                  30          
Ser His Arg Ile Leu Ser Ser Gly Gly Ser Trp Thr Leu Gln Leu Leu
        35                  40                  45              
Leu Tyr Ser Ser Leu Pro His Ser Glu Asn Gln Gln Arg Ser Glu Leu
    50                  55                  60                  
Pro Gln Met Thr Asp Gly Lys Tyr Pro Ala Trp Ser Trp Ile Thr Lys
65                  70                  75                  80  
Leu Tyr Lys Leu
                


<210> 917
<211> 97
<212> PRT
<213> Homo sapiens

<400> 917
Met Gly Lys Lys Gln Ser Arg Lys Ala Glu Asn Tyr Lys Asn Gln Ser
 1               5                  10                  15      
Ala Ser Pro Pro Pro Lys Asp Arg Ser Ser Ser Pro Ala Thr Glu Gln
            20                  25                  30          
Ser Trp Thr Gln Asn Asp Phe Asp Glu Leu Arg Glu Glu Gly Phe Arg
        35                  40                  45              
Glu Ser Asp Phe Ser Glu Leu Lys Glu Glu Val Arg Thr His Arg Lys
    50                  55                  60                  
Glu Ala Lys Asn Leu Glu Lys Arg Leu Asp Lys Trp Leu Thr Arg Val
65                  70                  75                  80  
Thr Ser Val Glu Lys Ser Leu Asn Asp Leu Met Glu Leu Lys Thr Met
                85                  90                  95      
Ala
    


<210> 918
<211> 133
<212> PRT
<213> Homo sapiens

<400> 918
Met Gln Pro Thr Leu Ser Ala Val Ser Ser Cys Thr Ala Pro Pro Arg
 1               5                  10                  15      
Pro Arg Ser Arg Arg Ser Thr Arg Pro Pro Ser Ser Arg Leu Asn Arg
            20                  25                  30          
Ser Arg Ser Arg Ser Thr Ser Gly Ser Ile Gly Gly Met Ala Gly Val
        35                  40                  45              
Gly Val Gly Ala Gly Ala Gly Gln Gly Arg Ala Gly Ala Glu Gly Gly
    50                  55                  60                  
Gly Gly Gly Ala Pro Leu Arg Arg Ile Leu Ser Cys Arg Leu Leu Ala
65                  70                  75                  80  
Thr Lys Trp Val Arg Ser Pro Trp Arg Leu Thr Val Pro Ser Ser Ser
                85                  90                  95      
Arg Gly Leu Glu Met Val Ala Arg Arg Pro Pro Pro Ala Pro Asp Ser
            100                 105                 110         
Ala Leu Pro Glu Asp Pro Ala Pro Pro His Ala Ser Leu Ser Pro Ser
        115                 120                 125             
Arg Leu Arg Leu Ser
    130             


<210> 919
<211> 1644
<212> PRT
<213> Homo sapiens

<400> 919
Asp Leu Ser Gly Ser Ile Asp Asp Leu Pro Met Gly Thr Glu Gly Ala
 1               5                  10                  15      
Leu Ser Pro Gly Val Ser Thr Ser Gly Ile Ser Ser Ser Gln Gly Glu
            20                  25                  30          
Gln Ser Asn Pro Ala Gln Ser Pro Phe Ser Pro His Thr Ser Pro His
        35                  40                  45              
Leu Pro Gly Ile Arg Gly Pro Ser Pro Ser Pro Val Gly Ser Pro Ala
    50                  55                  60                  
Ser Val Ala Gln Ser Arg Ser Gly Pro Leu Ser Pro Ala Ala Val Pro
65                  70                  75                  80  
Gly Asn Gln Met Pro Pro Arg Pro Pro Ser Gly Gln Ser Asp Ser Ile
                85                  90                  95      
Met His Pro Ser Met Asn Gln Ser Ser Ile Ala Gln Asp Arg Gly Tyr
            100                 105                 110         
Met Gln Arg Asn Pro Gln Met Pro Gln Tyr Ser Ser Pro Gln Pro Gly
        115                 120                 125             
Ser Ala Leu Ser Pro Arg Gln Pro Ser Gly Gly Gln Ile His Thr Gly
    130                 135                 140                 
Met Gly Ser Tyr Gln Gln Asn Ser Met Gly Ser Tyr Gly Pro Gln Gly
145                 150                 155                 160 
Gly Gln Tyr Gly Pro Gln Gly Gly Tyr Pro Arg Gln Pro Asn Tyr Asn
                165                 170                 175     
Ala Leu Pro Asn Ala Asn Tyr Pro Ser Ala Gly Met Ala Gly Gly Ile
            180                 185                 190         
Asn Pro Met Gly Ala Gly Gly Gln Met His Gly Gln Pro Gly Ile Pro
        195                 200                 205             
Pro Tyr Gly Thr Leu Pro Pro Gly Arg Met Ser His Ala Ser Met Gly
    210                 215                 220                 
Asn Arg Pro Tyr Gly Pro Asn Met Ala Asn Met Pro Pro Gln Val Gly
225                 230                 235                 240 
Ser Gly Met Cys Pro Pro Pro Gly Gly Met Asn Arg Lys Thr Gln Glu
                245                 250                 255     
Thr Ala Val Ala Met His Val Ala Ala Asn Ser Ile Gln Asn Arg Pro
            260                 265                 270         
Pro Gly Tyr Pro Asn Met Asn Gln Gly Gly Met Met Gly Thr Gly Pro
        275                 280                 285             
Pro Tyr Gly Gln Gly Ile Asn Ser Met Ala Gly Met Ile Asn Pro Gln
    290                 295                 300                 
Gly Pro Pro Tyr Ser Met Gly Gly Thr Met Ala Asn Asn Ser Ala Gly
305                 310                 315                 320 
Met Ala Ala Ser Pro Glu Met Met Gly Leu Gly Asp Val Lys Leu Thr
                325                 330                 335     
Pro Ala Thr Lys Met Asn Asn Lys Ala Asp Gly Thr Pro Lys Thr Glu
            340                 345                 350         
Ser Lys Ser Lys Lys Ser Ser Ser Ser Thr Thr Thr Asn Glu Lys Ile
        355                 360                 365             
Thr Lys Leu Tyr Glu Leu Gly Gly Glu Pro Glu Arg Lys Met Trp Val
    370                 375                 380                 
Asp Arg Tyr Leu Ala Phe Thr Glu Glu Lys Ala Met Gly Met Thr Asn
385                 390                 395                 400 
Leu Pro Ala Val Gly Arg Lys Pro Leu Asp Leu Tyr Arg Leu Tyr Val
                405                 410                 415     
Ser Val Lys Glu Ile Gly Gly Leu Thr Gln Val Asn Lys Asn Lys Lys
            420                 425                 430         
Trp Arg Glu Leu Ala Thr Asn Leu Asn Val Gly Thr Ser Ser Ser Ala
        435                 440                 445             
Ala Ser Ser Leu Lys Lys Gln Tyr Ile Gln Cys Leu Tyr Ala Phe Glu
    450                 455                 460                 
Cys Lys Ile Glu Arg Gly Glu Asp Pro Pro Pro Asp Ile Phe Ala Ala
465                 470                 475                 480 
Ala Asp Ser Lys Lys Ser Gln Pro Lys Ile Gln Pro Pro Ser Pro Ala
                485                 490                 495     
Gly Ser Gly Ser Met Gln Gly Pro Gln Thr Pro Gln Ser Thr Ser Ser
            500                 505                 510         
Ser Met Ala Glu Gly Gly Asp Leu Lys Pro Pro Thr Pro Ala Ser Thr
        515                 520                 525             
Pro His Ser Gln Ile Pro Pro Leu Pro Gly Met Arg Ser Asn Ser Val
    530                 535                 540                 
Gly Ile Gln Asp Ala Phe Asn Asp Gly Ser Asp Ser Thr Phe Gln Lys
545                 550                 555                 560 
Arg Asn Ser Met Thr Pro Asn Pro Gly Tyr Gln Pro Ser Met Asn Thr
                565                 570                 575     
Ser Asp Met Met Gly Arg Met Ser Tyr Glu Pro Asn Lys Asp Pro Tyr
            580                 585                 590         
Gly Ser Met Arg Lys Ala Pro Gly Ser Asp Pro Phe Met Ser Ser Gly
        595                 600                 605             
Gln Gly Pro Asn Gly Gly Met Gly Asp Pro Tyr Ser Arg Ala Ala Gly
    610                 615                 620                 
Pro Gly Leu Gly Asn Val Ala Met Gly Pro Arg Gln His Tyr Pro Tyr
625                 630                 635                 640 
Gly Gly Pro Tyr Asp Arg Val Arg Thr Glu Pro Gly Ile Gly Pro Glu
                645                 650                 655     
Gly Asn Met Ser Thr Gly Ala Pro Gln Pro Asn Leu Met Pro Ser Asn
            660                 665                 670         
Pro Asp Ser Gly Met Tyr Ser Pro Ser Arg Tyr Pro Pro Gln Gln Gln
        675                 680                 685             
Gln Gln Gln Gln Gln Arg His Asp Ser Tyr Gly Asn Gln Phe Ser Thr
    690                 695                 700                 
Gln Gly Thr Pro Ser Gly Ser Pro Phe Pro Ser Gln Gln Thr Thr Met
705                 710                 715                 720 
Tyr Gln Gln Gln Gln Gln Asn Tyr Lys Arg Pro Met Asp Gly Thr Tyr
                725                 730                 735     
Gly Pro Pro Ala Lys Arg His Glu Gly Glu Met Tyr Ser Val Pro Tyr
            740                 745                 750         
Ser Thr Gly Gln Gly Gln Pro Gln Gln Gln Gln Leu Pro Pro Ala Gln
        755                 760                 765             
Pro Gln Pro Ala Ser Gln Gln Gln Ala Ala Gln Pro Ser Pro Gln Gln
    770                 775                 780                 
Asp Val Tyr Asn Gln Tyr Gly Asn Ala Tyr Pro Ala Thr Ala Thr Ala
785                 790                 795                 800 
Ala Thr Glu Arg Arg Pro Ala Gly Gly Pro Gln Asn Gln Phe Pro Phe
                805                 810                 815     
Gln Phe Gly Arg Asp Arg Val Ser Ala Pro Pro Gly Thr Asn Ala Gln
            820                 825                 830         
Gln Asn Met Pro Pro Gln Met Met Gly Gly Pro Ile Gln Ala Ser Ala
        835                 840                 845             
Glu Val Ala Gln Gln Gly Thr Met Trp Gln Gly Arg Asn Asp Met Thr
    850                 855                 860                 
Tyr Asn Tyr Ala Asn Arg Gln Ser Thr Gly Ser Ala Pro Gln Gly Pro
865                 870                 875                 880 
Ala Tyr His Gly Val Asn Arg Thr Asp Glu Met Leu His Thr Asp Gln
                885                 890                 895     
Arg Ala Asn His Glu Gly Ser Trp Pro Ser His Gly Thr Arg Gln Pro
            900                 905                 910         
Pro Tyr Gly Pro Ser Ala Pro Val Pro Pro Met Thr Arg Pro Pro Pro
        915                 920                 925             
Ser Asn Tyr Gln Pro Pro Pro Ser Met Gln Asn His Ile Pro Gln Val
    930                 935                 940                 
Ser Ser Pro Ala Pro Leu Pro Arg Pro Met Glu Asn Arg Thr Ser Pro
945                 950                 955                 960 
Ser Lys Ser Pro Phe Leu His Ser Gly Met Lys Met Gln Lys Ala Gly
                965                 970                 975     
Pro Pro Val Pro Ala Ser His Ile Ala Pro Ala Pro Val Gln Pro Pro
            980                 985                 990         
Met Ile Arg Arg Asp Ile Thr Phe Pro Pro Gly Ser Val Glu Ala Thr
        995                 1000                1005            
Gln Pro Val Leu Lys Gln Arg Arg Arg Leu Thr Met Lys Asp Ile Gly
    1010                1015                1020                
Thr Pro Glu Ala Trp Arg Val Met Met Ser Leu Lys Ser Gly Leu Leu
1025                1030                1035                1040
Ala Glu Ser Thr Trp Ala Leu Asp Thr Ile Asn Ile Leu Leu Tyr Asp
                1045                1050                1055    
Asp Asn Ser Ile Met Thr Phe Asn Leu Ser Gln Leu Pro Gly Leu Leu
            1060                1065                1070        
Glu Leu Leu Val Glu Tyr Phe Arg Arg Cys Leu Ile Glu Ile Phe Gly
        1075                1080                1085            
Ile Leu Lys Glu Tyr Glu Val Gly Asp Pro Gly Gln Arg Thr Leu Leu
    1090                1095                1100                
Asp Pro Gly Arg Phe Ser Lys Val Ser Ser Pro Ala Pro Met Glu Gly
1105                1110                1115                1120
Gly Glu Glu Glu Glu Glu Leu Leu Gly Pro Lys Leu Glu Glu Glu Glu
                1125                1130                1135    
Glu Glu Glu Val Val Glu Asn Asp Glu Glu Ile Ala Phe Ser Gly Lys
            1140                1145                1150        
Asp Lys Pro Ala Ser Glu Asn Ser Glu Glu Lys Leu Ile Ser Lys Phe
        1155                1160                1165            
Asp Lys Leu Pro Val Lys Ile Val Gln Lys Asn Asp Pro Phe Val Val
    1170                1175                1180                
Asp Cys Ser Asp Lys Leu Gly Arg Val Gln Glu Phe Asp Ser Gly Leu
1185                1190                1195                1200
Leu His Trp Arg Ile Gly Gly Gly Asp Thr Thr Glu His Ile Gln Thr
                1205                1210                1215    
His Phe Glu Ser Lys Thr Glu Leu Leu Pro Ser Arg Pro His Ala Pro
            1220                1225                1230        
Cys Pro Pro Ala Pro Arg Lys His Val Thr Thr Ala Glu Gly Thr Pro
        1235                1240                1245            
Gly Thr Thr Asp Gln Glu Gly Pro Pro Pro Asp Gly Pro Pro Glu Lys
    1250                1255                1260                
Arg Ile Thr Ala Thr Met Asp Asp Met Leu Ser Thr Arg Ser Ser Thr
1265                1270                1275                1280
Leu Thr Glu Asp Gly Ala Lys Ser Ser Glu Ala Ile Lys Glu Ser Ser
                1285                1290                1295    
Lys Phe Pro Phe Gly Ile Ser Pro Ala Gln Ser His Arg Asn Ile Lys
            1300                1305                1310        
Ile Leu Glu Asp Glu Pro His Ser Lys Asp Glu Thr Pro Leu Cys Thr
        1315                1320                1325            
Leu Leu Asp Trp Gln Asp Ser Leu Ala Lys Arg Cys Val Cys Val Ser
    1330                1335                1340                
Asn Thr Ile Arg Ser Leu Ser Phe Val Pro Gly Asn Asp Phe Glu Met
1345                1350                1355                1360
Ser Lys His Pro Gly Leu Leu Leu Ile Leu Gly Lys Leu Ile Leu Leu
                1365                1370                1375    
His His Lys His Pro Glu Arg Lys Gln Ala Pro Leu Thr Tyr Glu Lys
            1380                1385                1390        
Glu Glu Glu Gln Asp Gln Gly Val Ser Cys Asn Lys Val Glu Trp Trp
        1395                1400                1405            
Trp Asp Cys Leu Glu Met Leu Arg Glu Asn Thr Leu Val Thr Leu Ala
    1410                1415                1420                
Asn Ile Ser Gly Gln Leu Asp Leu Ser Pro Tyr Pro Glu Ser Ile Cys
1425                1430                1435                1440
Leu Pro Val Leu Asp Gly Leu Leu His Trp Ala Val Cys Pro Ser Ala
                1445                1450                1455    
Glu Ala Gln Asp Pro Phe Ser Thr Leu Gly Pro Asn Ala Val Leu Ser
            1460                1465                1470        
Pro Gln Arg Leu Val Leu Glu Thr Leu Ser Lys Leu Ser Ile Gln Asp
        1475                1480                1485            
Asn Asn Val Asp Leu Ile Leu Ala Thr Pro Pro Phe Ser Arg Leu Glu
    1490                1495                1500                
Lys Leu Tyr Ser Thr Met Val Arg Phe Leu Ser Asp Arg Lys Asn Pro
1505                1510                1515                1520
Val Cys Arg Glu Met Ala Val Val Leu Leu Ala Asn Leu Ala Gln Gly
                1525                1530                1535    
Asp Ser Leu Ala Ala Arg Ala Ile Ala Val Gln Lys Gly Ser Ile Gly
            1540                1545                1550        
Asn Leu Leu Gly Phe Leu Glu Asp Ser Leu Ala Ala Thr Gln Phe Gln
        1555                1560                1565            
Gln Ser Gln Ala Ser Leu Leu His Met Gln Asn Pro Pro Phe Glu Pro
    1570                1575                1580                
Thr Ser Val Asp Met Met Arg Arg Ala Ala Arg Ala Leu Leu Ala Leu
1585                1590                1595                1600
Ala Lys Val Asp Glu Asn His Ser Glu Phe Thr Leu Tyr Glu Ser Arg
                1605                1610                1615    
Leu Leu Asp Ile Ser Val Ser Pro Leu Met Asn Ser Leu Val Ser Gln
            1620                1625                1630        
Val Ile Cys Asp Val Leu Phe Leu Ile Gly Gln Ser
        1635                1640                


<210> 920
<211> 223
<212> PRT
<213> Homo sapiens

<400> 920
Met Ala Ser Lys Leu Leu Arg Ala Val Ile Leu Gly Pro Pro Gly Ser
 1               5                  10                  15      
Gly Lys Gly Thr Val Cys Gln Arg Ile Ala Gln Asn Phe Gly Leu Gln
            20                  25                  30          
His Leu Ser Ser Gly His Phe Leu Arg Glu Asn Ile Lys Ala Ser Thr
        35                  40                  45              
Glu Val Gly Glu Met Ala Lys Gln Tyr Ile Glu Lys Ser Leu Leu Val
    50                  55                  60                  
Pro Asp His Val Ile Thr Arg Leu Met Met Ser Glu Leu Glu Asn Arg
65                  70                  75                  80  
Arg Gly Gln His Trp Leu Leu Asp Gly Phe Pro Arg Thr Leu Gly Gln
                85                  90                  95      
Ala Glu Ala Leu Asp Lys Ile Cys Glu Val Asp Leu Val Ile Ser Leu
            100                 105                 110         
Asn Ile Pro Phe Glu Thr Leu Lys Asp Arg Leu Ser Arg Arg Trp Ile
        115                 120                 125             
His Pro Pro Ser Gly Arg Val Tyr Asn Leu Asp Phe Asn Pro Pro His
    130                 135                 140                 
Val His Gly Ile Asp Asp Val Thr Gly Glu Pro Leu Val Gln Gln Glu
145                 150                 155                 160 
Asp Asp Lys Pro Glu Ala Val Ala Ala Arg Leu Arg Gln Tyr Lys Asp
                165                 170                 175     
Val Ala Lys Pro Val Ile Glu Leu Tyr Lys Ser Arg Gly Val Leu His
            180                 185                 190         
Gln Phe Ser Gly Thr Glu Thr Asn Lys Ile Trp Pro Tyr Val Tyr Thr
        195                 200                 205             
Leu Phe Ser Asn Lys Ile Thr Pro Ile Gln Ser Lys Glu Ala Tyr
    210                 215                 220             


<210> 921
<211> 610
<212> PRT
<213> Homo sapiens

<400> 921
Ala Arg Ala Pro Ala Ser Leu Thr Ala Gly Asp Thr Leu Ser Val Pro
 1               5                  10                  15      
Ala Pro Ala Val Gln Pro Glu Glu Ser Leu Lys Thr Asp Tyr Pro Glu
            20                  25                  30          
Ile Gly Glu Gly Lys Pro Thr Pro Ala Leu Ser Glu Glu Ala Ser Ser
        35                  40                  45              
Ser Ser Ile Arg Glu Arg Pro Pro Glu Glu Val Ala Ala Arg Leu Ala
    50                  55                  60                  
Gln Gln Glu Lys Gln Glu Gln Val Lys Ile Glu Ser Leu Ala Lys Ser
65                  70                  75                  80  
Leu Glu Asp Ala Leu Arg Gln Thr Ala Ser Val Thr Leu Gln Ala Ile
                85                  90                  95      
Ala Ala Gln Asn Ala Ala Val Gln Ala Val Asn Ala His Ser Asn Ile
            100                 105                 110         
Leu Lys Ala Ala Met Asp Asn Ser Glu Ile Ala Gly Glu Lys Lys Ser
        115                 120                 125             
Ala Gln Trp Arg Thr Val Glu Gly Ala Leu Lys Glu Arg Arg Lys Ala
    130                 135                 140                 
Val Asp Glu Ala Ala Asp Ala Leu Leu Lys Ala Lys Glu Glu Leu Glu
145                 150                 155                 160 
Lys Met Lys Ser Val Ile Glu Asn Thr Lys Lys Lys Glu Val Ala Gly
                165                 170                 175     
Ala Lys Pro His Ile Ser Ala Ala Glu Gly Lys Leu His Asn Met Ile
            180                 185                 190         
Val Asp Leu Asp Asn Val Val Lys Lys Val Gln Ala Ala Gln Ser Glu
        195                 200                 205             
Ala Lys Val Val Ser Gln Tyr His Glu Leu Val Val Gln Ala Arg Asp
    210                 215                 220                 
Asp Phe Lys Arg Glu Leu Asp Ser Ile Thr Pro Glu Val Leu Pro Gly
225                 230                 235                 240 
Trp Lys Gly Met Thr Asp Lys Leu Ser Thr Asp Asp Leu Asn Ser Leu
                245                 250                 255     
Ile Ala His Ala His Arg Arg Ile Asp Gln Leu Asn Arg Glu Leu Ala
            260                 265                 270         
Glu Gln Lys Ala Thr Glu Lys Gln His Ile Thr Leu Ala Leu Glu Lys
        275                 280                 285             
Gln Lys Leu Glu Glu Lys Arg Ala Phe Asp Ser Ala Val Ala Lys Ala
    290                 295                 300                 
Leu Glu His His Arg Ser Glu Ile Gln Ala Glu Gln Asp Arg Lys Ile
305                 310                 315                 320 
Glu Glu Val Arg Asp Ala Met Glu Asn Glu Met Arg Thr Gln Leu Arg
                325                 330                 335     
Arg Gln Ala Ala Ala His Thr Asp His Leu Arg Asp Val Leu Arg Val
            340                 345                 350         
Gln Glu Gln Glu Leu Lys Ser Glu Phe Glu Gln Asn Leu Ser Glu Lys
        355                 360                 365             
Leu Ser Glu Gln Glu Leu Gln Phe Arg Arg Leu Ser Gln Glu Gln Val
    370                 375                 380                 
Asp Asn Phe Thr Leu Asp Ile Asn Thr Ala Tyr Ala Arg Leu Arg Gly
385                 390                 395                 400 
Ile Glu Gln Ala Val Gln Ser His Ala Val Ala Glu Glu Glu Ala Arg
                405                 410                 415     
Lys Ala His Gln Leu Trp Leu Ser Val Glu Ala Leu Lys Tyr Ser Met
            420                 425                 430         
Lys Thr Ser Ser Ala Glu Thr Pro Thr Ile Pro Leu Gly Ser Ala Val
        435                 440                 445             
Glu Ala Ile Lys Ala Asn Cys Ser Asp Asn Glu Phe Thr Gln Ala Leu
    450                 455                 460                 
Thr Ala Ala Ile Pro Pro Glu Ser Leu Thr Arg Gly Val Tyr Ser Glu
465                 470                 475                 480 
Glu Thr Leu Arg Ala Arg Phe Tyr Ala Val Gln Lys Leu Ala Arg Arg
                485                 490                 495     
Val Ala Met Ile Asp Glu Thr Arg Asn Ser Leu Tyr Gln Tyr Phe Leu
            500                 505                 510         
Ser Tyr Leu Gln Ser Leu Leu Leu Phe Pro Pro Gln Gln Leu Lys Pro
        515                 520                 525             
Pro Pro Glu Leu Cys Pro Glu Asp Ile Asn Thr Phe Lys Leu Leu Ser
    530                 535                 540                 
Tyr Ala Ser Tyr Cys Ile Glu His Gly Asp Leu Glu Leu Ala Ala Lys
545                 550                 555                 560 
Phe Val Asn Gln Leu Lys Gly Glu Ser Arg Arg Val Ala Gln Asp Trp
                565                 570                 575     
Leu Lys Glu Ala Arg Met Thr Leu Glu Thr Lys Gln Ile Val Glu Ile
            580                 585                 590         
Leu Thr Ala Tyr Ala Ser Ala Val Gly Ile Gly Thr Thr Gln Val Gln
        595                 600                 605             
Pro Glu
    610 


<210> 922
<211> 527
<212> PRT
<213> Homo sapiens

<400> 922
Met Glu Ser Gln Gly Val Pro Pro Gly Pro Tyr Arg Ala Thr Lys Leu
 1               5                  10                  15      
Trp Asn Glu Val Thr Thr Ser Phe Arg Ala Gly Met Pro Leu Arg Lys
            20                  25                  30          
His Arg Gln His Phe Lys Lys Tyr Gly Asn Cys Phe Thr Ala Gly Glu
        35                  40                  45              
Ala Val Asp Trp Leu Tyr Asp Leu Leu Arg Asn Asn Ser Asn Phe Gly
    50                  55                  60                  
Pro Glu Val Thr Arg Gln Gln Thr Ile Gln Leu Leu Arg Lys Phe Leu
65                  70                  75                  80  
Lys Asn His Val Ile Glu Asp Ile Lys Gly Arg Trp Gly Ser Glu Asn
                85                  90                  95      
Val Asp Asp Asn Asn Gln Leu Phe Arg Phe Pro Ala Thr Ser Pro Leu
            100                 105                 110         
Lys Thr Leu Pro Arg Arg Tyr Pro Glu Leu Arg Lys Asn Asn Ile Glu
        115                 120                 125             
Asn Phe Ser Lys Asp Lys Asp Ser Ile Phe Lys Leu Arg Asn Leu Ser
    130                 135                 140                 
Arg Arg Thr Pro Lys Arg His Gly Leu His Leu Ser Gln Glu Asn Gly
145                 150                 155                 160 
Glu Lys Ile Lys His Glu Ile Ile Asn Glu Asp Gln Glu Asn Ala Ile
                165                 170                 175     
Asp Asn Arg Glu Leu Ser Gln Glu Asp Val Glu Glu Val Trp Arg Tyr
            180                 185                 190         
Val Ile Leu Ile Tyr Leu Gln Thr Ile Leu Gly Val Pro Ser Leu Glu
        195                 200                 205             
Glu Val Ile Asn Pro Lys Gln Val Ile Pro Gln Tyr Ile Met Tyr Asn
    210                 215                 220                 
Met Ala Asn Thr Ser Lys Arg Gly Val Val Ile Leu Gln Asn Lys Ser
225                 230                 235                 240 
Asp Asp Leu Pro His Trp Val Leu Ser Ala Met Lys Cys Leu Ala Asn
                245                 250                 255     
Trp Pro Arg Ser Asn Asp Met Asn Asn Pro Thr Tyr Val Gly Phe Glu
            260                 265                 270         
Arg Asp Val Phe Arg Thr Ile Ala Asp Tyr Phe Leu Asp Leu Pro Glu
        275                 280                 285             
Pro Leu Leu Thr Phe Glu Tyr Tyr Glu Leu Phe Val Asn Ile Leu Gly
    290                 295                 300                 
Leu Leu Gln Pro His Leu Glu Arg Val Ala Ile Asp Ala Leu Gln Leu
305                 310                 315                 320 
Cys Cys Leu Leu Leu Pro Pro Pro Asn Arg Arg Lys Leu Gln Leu Leu
                325                 330                 335     
Met Arg Met Ile Ser Arg Met Ser Gln Asn Val Asp Met Pro Lys Leu
            340                 345                 350         
His Asp Ala Met Gly Thr Arg Ser Leu Met Ile His Thr Phe Ser Arg
        355                 360                 365             
Cys Val Leu Cys Cys Ala Glu Glu Val Asp Leu Asp Glu Leu Leu Ala
    370                 375                 380                 
Gly Arg Leu Val Ser Phe Leu Met Asp His His Gln Glu Ile Leu Gln
385                 390                 395                 400 
Val Pro Ser Tyr Leu Gln Thr Ala Val Glu Lys His Leu Asp Tyr Leu
                405                 410                 415     
Lys Lys Gly His Ile Glu Asn Pro Gly Asp Gly Leu Phe Ala Pro Leu
            420                 425                 430         
Pro Thr Tyr Ser Tyr Cys Lys Gln Ile Ser Ala Gln Glu Phe Asp Glu
        435                 440                 445             
Gln Lys Val Ser Thr Ser Gln Ala Ala Ile Ala Glu Leu Leu Glu Asn
    450                 455                 460                 
Ile Ile Lys Asn Arg Ser Leu Pro Leu Lys Glu Lys Arg Lys Lys Leu
465                 470                 475                 480 
Lys Gln Phe Gln Lys Glu Tyr Pro Leu Ile Tyr Gln Lys Arg Phe Pro
                485                 490                 495     
Thr Thr Glu Ser Glu Ala Ala Leu Phe Gly Asp Lys Pro Thr Ile Lys
            500                 505                 510         
Gln Pro Met Leu Ile Leu Arg Lys Pro Lys Phe Arg Ser Leu Arg
        515                 520                 525         


<210> 923
<211> 197
<212> PRT
<213> Homo sapiens

<400> 923
Met Thr Ala Arg Gly Thr Pro Ser Arg Phe Leu Ala Ser Val Leu His
 1               5                  10                  15      
Asn Gly Leu Gly Arg Tyr Val Gln Gln Leu Gln Arg Leu Ser Phe Ser
            20                  25                  30          
Val Ser Arg Asp Gly Ala Ser Ser Arg Gly Ala Arg Glu Phe Val Glu
        35                  40                  45              
Arg Glu Val Ile Asp Phe Ala Arg Arg Asn Pro Gly Val Val Ile Tyr
    50                  55                  60                  
Val Asn Ser Arg Pro Cys Cys Val Pro Arg Val Val Ala Glu Tyr Arg
65                  70                  75                  80  
Glu Trp Gly Arg Ala Arg Ala Gly Gly Arg Asp Gln Gly Leu Asp Pro
                85                  90                  95      
Leu Ser Ser Phe Ser Leu Gly Arg Thr Gly Gln Leu Pro Pro Thr Leu
            100                 105                 110         
Thr Pro Leu Leu Pro Val Asn Gly Ala Val Arg Glu Glu Ser Ile His
        115                 120                 125             
Cys Lys Ser Val Glu Glu Ile Ser Thr Leu Val Gln Lys Leu Ala Asp
    130                 135                 140                 
Gln Ser Gly Leu Asp Val Ile Arg Ile Arg Lys Pro Phe His Thr Asp
145                 150                 155                 160 
Asn Pro Ser Ile Gln Gly Gln Trp His Pro Phe Thr Asn Lys Pro Thr
                165                 170                 175     
Thr Phe Arg Gly Leu Arg Pro Arg Glu Val Gln Asp Pro Ala Pro Ala
            180                 185                 190         
Gln Val Gln Ala Gln
        195         


<210> 924
<211> 502
<212> PRT
<213> Homo sapiens

<400> 924
Met Ala Ser Lys Lys Leu Gly Ala Asp Phe His Gly Thr Phe Ser Tyr
 1               5                  10                  15      
Leu Asp Asp Val Pro Phe Lys Thr Gly Asp Lys Phe Lys Thr Pro Ala
            20                  25                  30          
Lys Val Gly Leu Pro Ile Gly Phe Ser Leu Pro Asp Cys Leu Gln Val
        35                  40                  45              
Val Arg Glu Val Gln Tyr Asp Phe Ser Leu Glu Lys Lys Thr Ile Glu
    50                  55                  60                  
Trp Ala Glu Glu Ile Lys Lys Ile Glu Glu Ala Glu Arg Glu Ala Glu
65                  70                  75                  80  
Cys Lys Ile Ala Glu Ala Glu Ala Lys Val Asn Ser Lys Ser Gly Pro
                85                  90                  95      
Glu Gly Asp Ser Lys Met Ser Phe Ser Lys Thr His Ser Thr Ala Thr
            100                 105                 110         
Met Pro Pro Pro Ile Asn Pro Ile Leu Ala Ser Leu Gln His Asn Ser
        115                 120                 125             
Ile Leu Thr Pro Thr Arg Val Ser Ser Ser Ala Thr Lys Gln Lys Val
    130                 135                 140                 
Leu Ser Pro Pro His Ile Lys Ala Asp Phe Asn Leu Ala Asp Phe Glu
145                 150                 155                 160 
Cys Glu Glu Asp Pro Phe Asp Asn Leu Glu Leu Lys Thr Ile Asp Glu
                165                 170                 175     
Lys Glu Glu Leu Arg Asn Ile Leu Val Gly Thr Thr Gly Pro Ile Met
            180                 185                 190         
Ala Gln Leu Leu Asp Asn Asn Leu Pro Arg Gly Gly Ser Gly Ser Val
        195                 200                 205             
Leu Gln Asp Glu Glu Val Leu Ala Ser Leu Glu Arg Ala Thr Leu Asp
    210                 215                 220                 
Phe Lys Pro Leu His Lys Pro Asn Gly Phe Ile Thr Leu Pro Gln Leu
225                 230                 235                 240 
Gly Asn Cys Glu Lys Met Ser Leu Ser Ser Lys Val Ser Leu Pro Pro
                245                 250                 255     
Ile Pro Ala Val Ser Asn Ile Lys Ser Leu Ser Phe Pro Lys Leu Asp
            260                 265                 270         
Ser Asp Asp Ser Asn Gln Lys Thr Ala Lys Leu Ala Ser Thr Phe His
        275                 280                 285             
Ser Thr Ser Cys Leu Arg Asn Gly Thr Phe Gln Asn Ser Leu Lys Pro
    290                 295                 300                 
Ser Thr Gln Ser Ser Ala Ser Glu Leu Asn Gly His His Thr Leu Gly
305                 310                 315                 320 
Leu Ser Ala Leu Asn Leu Asp Ser Gly Thr Glu Met Pro Ala Leu Thr
                325                 330                 335     
Ser Ser Gln Met Pro Ser Leu Ser Val Leu Ser Val Cys Thr Glu Glu
            340                 345                 350         
Ser Ser Pro Pro Asn Thr Gly Pro Thr Val Thr Pro Pro Asn Phe Ser
        355                 360                 365             
Val Ser Gln Val Pro Asn Met Pro Ser Cys Pro Gln Ala Tyr Ser Glu
    370                 375                 380                 
Leu Gln Met Leu Ser Pro Ser Glu Arg Gln Cys Val Glu Thr Val Val
385                 390                 395                 400 
Asn Met Gly Tyr Ser Tyr Glu Cys Val Leu Arg Ala Met Lys Lys Lys
                405                 410                 415     
Gly Glu Asn Ile Glu Gln Ile Leu Asp Tyr Leu Phe Ala His Gly Gln
            420                 425                 430         
Leu Cys Glu Lys Gly Phe Asp Pro Leu Leu Val Glu Glu Ala Leu Glu
        435                 440                 445             
Met His Gln Cys Ser Glu Glu Lys Met Met Glu Phe Leu Gln Leu Met
    450                 455                 460                 
Ser Lys Phe Lys Glu Met Gly Phe Glu Leu Lys Asp Ile Lys Glu Val
465                 470                 475                 480 
Leu Leu Leu His Asn Asn Asp Gln Asp Asn Ala Leu Glu Asp Leu Met
                485                 490                 495     
Ala Arg Ala Gly Ala Ser
            500         


<210> 925
<211> 213
<212> PRT
<213> Homo sapiens

<400> 925
Met Ala Val Leu Ser Ala Pro Gly Leu Arg Gly Phe Arg Ile Leu Gly
 1               5                  10                  15      
Leu Arg Ser Ser Val Gly Leu Ala Val Gln Ala Arg Gly Val His Gln
            20                  25                  30          
Ser Val Ala Thr Asp Gly Pro Ser Ser Thr Gln Pro Ala Leu Pro Lys
        35                  40                  45              
Ala Arg Ala Val Ala Pro Lys Pro Ser Ser Arg Gly Glu Tyr Val Val
    50                  55                  60                  
Ala Lys Leu Asp Asp Leu Val Asn Trp Ala Arg Arg Ser Ser Leu Trp
65                  70                  75                  80  
Pro Met Thr Phe Gly Leu Ala Cys Cys Ala Val Glu Met Met His Met
                85                  90                  95      
Ala Ala Pro Arg Tyr Asp Met Asp Arg Phe Gly Val Val Phe Arg Ala
            100                 105                 110         
Ser Pro Arg Gln Ser Asp Val Met Ile Val Ala Gly Thr Leu Thr Asn
        115                 120                 125             
Lys Met Ala Pro Ala Leu Arg Lys Val Tyr Asp Gln Met Pro Glu Pro
    130                 135                 140                 
Arg Tyr Val Val Ser Met Gly Ser Cys Ala Asn Gly Gly Gly Tyr Tyr
145                 150                 155                 160 
His Tyr Ser Tyr Ser Val Val Arg Gly Cys Asp Arg Ile Val Pro Val
                165                 170                 175     
Asp Ile Tyr Ile Pro Gly Cys Pro Pro Thr Ala Glu Ala Leu Leu Tyr
            180                 185                 190         
Gly Ile Leu Gln Leu Gln Arg Lys Ile Lys Arg Glu Arg Arg Leu Gln
        195                 200                 205             
Ile Trp Tyr Arg Arg
    210             


<210> 926
<211> 580
<212> PRT
<213> Homo sapiens

<400> 926
Met Ala Thr Thr Gly Ala Ala Ala Thr Thr Glu Ile Gly Asn Pro Glu
 1               5                  10                  15      
Tyr Lys Gln Pro Arg Ser Ile Phe Asp Leu Thr Ala Asp Phe Phe Asp
            20                  25                  30          
Ser Cys Arg Leu Ser Asn Pro Ser Glu Thr Gln Ser Ala Phe Gly Pro
        35                  40                  45              
Pro Lys Thr Phe Asp Pro Glu Glu Ala Glu Glu Asp Lys Ser Ser Lys
    50                  55                  60                  
Asp Gly Val Ile Leu Asp Arg Trp Thr Cys Asn Thr Cys Lys Ile Glu
65                  70                  75                  80  
Phe Leu Ser Leu Gln Asp Gln Arg Tyr His Phe Lys Ser Asp Ile His
                85                  90                  95      
Arg Leu Asn Ile Lys Leu Ser Val Ala Gly Lys Ala Ile Leu Lys Glu
            100                 105                 110         
Glu Asp Val Asp Glu Leu Thr Ser Glu Ser Val Gln Asp Tyr Asp Val
        115                 120                 125             
Ser Ser Ile Ser Gly Ser Glu Asp Glu Ala Glu Thr Arg Pro Pro Ser
    130                 135                 140                 
Phe His Phe Asp Ala Gln Lys Gly Ile Asp Lys Lys Lys Leu Phe Phe
145                 150                 155                 160 
Arg Leu Gln Ser Gly Asp Lys Val Ser Ile Trp Lys Cys Leu Ile Met
                165                 170                 175     
Asp Asp Ala Glu Ser Val Ser Phe Glu Asn Asp Arg Gly Val Ser Val
            180                 185                 190         
Asp Cys Cys Gly Ser Leu Val Glu Asn Glu Val Thr Glu Arg Leu Arg
        195                 200                 205             
Asn Leu Ile Arg Glu Asn Lys Asp Asp Arg Gln Met Arg Val Val Leu
    210                 215                 220                 
Leu Ala Ser Gly Gly His Phe Ala Gly Thr Val Phe Asn Gly Lys Ser
225                 230                 235                 240 
Val Val Ala His Lys Thr Phe His Arg Tyr Val Val Arg Ala Lys Ala
                245                 250                 255     
Gly Lys Lys Gln Ser Thr Lys Asp Ala Ser Gly Arg Ser Ile His Ser
            260                 265                 270         
Ala Gly Ala Ser Leu Arg Arg Tyr Asn Glu Leu Ala Leu Lys Lys Asp
        275                 280                 285             
Ile Gln Glu Leu Leu Ala Ser Trp Lys Pro Tyr Phe Asp Gly Ala Ala
    290                 295                 300                 
Cys Val Phe Val His Ala Pro Ser Ser Ser Arg Gln Leu Leu Phe Asn
305                 310                 315                 320 
Gly Gly Lys Pro Tyr Phe Ser Ser Gln Asn Cys Ala Val Arg Asn Val
                325                 330                 335     
Pro Phe Thr Ile Arg Arg Pro Thr Phe Lys Glu Ser Gln Arg Ile Tyr
            340                 345                 350         
Asn Gln Leu Thr Gln Ile Ala His Val Thr Glu Glu Ile Phe Val Asn
        355                 360                 365             
Arg Pro Glu Val Thr Lys Ala Asn Thr Val Val Gln Thr His Asn Glu
    370                 375                 380                 
Asp Ser Gly Lys Thr Ser Arg Lys Glu Glu Pro Asp Glu Thr Ser Ser
385                 390                 395                 400 
Ser Asn Ile Ile Leu Glu Glu Pro Asn Arg Ile Glu Glu Asp Ile Glu
                405                 410                 415     
Asp Gly Val Thr Gly Thr Ser Thr Ala Leu His Glu Ala Ala Lys Ser
            420                 425                 430         
Gly Asp Cys Glu Arg Val Met Glu Phe Leu Glu Glu Gly Met Asp Pro
        435                 440                 445             
Cys Ala Lys Asp Glu Arg Gly Arg Thr Pro Tyr Met Leu Ala Asn Glu
    450                 455                 460                 
Lys Glu Val Arg Asn Thr Phe Arg Arg Phe Met Ala Leu Asn Leu Glu
465                 470                 475                 480 
Lys Trp Asn Trp His Asp Ala Lys Val Pro Ser Pro Leu Thr Lys Glu
                485                 490                 495     
Met Glu Glu Ser Gln Ala Ala Lys Gln Ala Glu Lys Asp Ala Lys Gln
            500                 505                 510         
Lys Ala Arg Thr Lys Glu Leu Lys Lys Leu Arg Lys Ala Arg Glu Lys
        515                 520                 525             
Lys Ala Gln Ala Glu Ala Ala Gln Ala Glu Lys Glu Lys Pro Ile Ser
    530                 535                 540                 
Lys Val Glu Glu Val Arg Arg Ala Met Ala Ala Gln Arg Glu Lys Arg
545                 550                 555                 560 
Ala Ala Ala Ala Glu Arg Arg Met Ala Ser Leu Asn Ile Gln Ser Ser
                565                 570                 575     
Ser Ser Thr Ser
            580 


<210> 927
<211> 374
<212> PRT
<213> Homo sapiens

<400> 927
Val Thr Ser Phe Pro Val Val Gln Leu His Met Asn Arg Thr Ala Met
 1               5                  10                  15      
Arg Ala Ser Gln Lys Asp Phe Glu Asn Ser Met Asn Gln Val Lys Leu
            20                  25                  30          
Leu Lys Lys Asp Pro Gly Asn Glu Val Lys Leu Lys Leu Tyr Ala Leu
        35                  40                  45              
Tyr Lys Gln Ala Thr Glu Gly Pro Cys Asn Met Pro Lys Pro Gly Val
    50                  55                  60                  
Phe Asp Leu Ile Asn Lys Ala Lys Trp Asp Ala Trp Asn Ala Leu Gly
65                  70                  75                  80  
Ser Leu Pro Lys Glu Ala Ala Arg Gln Asn Tyr Val Asp Leu Val Ser
                85                  90                  95      
Ser Leu Ser Pro Ser Leu Glu Ser Ser Ser Gln Val Glu Pro Gly Thr
            100                 105                 110         
Asp Arg Lys Ser Thr Gly Phe Glu Thr Leu Val Val Thr Ser Glu Asp
        115                 120                 125             
Gly Ile Thr Lys Ile Met Phe Asn Arg Pro Lys Lys Lys Asn Ala Ile
    130                 135                 140                 
Asn Thr Glu Met Tyr His Glu Ile Met Arg Ala Leu Lys Ala Ala Ser
145                 150                 155                 160 
Lys Asp Asp Ser Ile Ile Thr Val Leu Thr Gly Asn Gly Asp Tyr Tyr
                165                 170                 175     
Ser Ser Gly Asn Asp Leu Thr Asn Phe Thr Asp Ile Pro Pro Gly Gly
            180                 185                 190         
Val Glu Glu Lys Ala Lys Asn Asn Ala Val Leu Leu Arg Glu Phe Val
        195                 200                 205             
Gly Cys Phe Ile Asp Phe Pro Lys Pro Leu Ile Ala Val Val Asn Gly
    210                 215                 220                 
Pro Ala Val Gly Ile Ser Val Thr Leu Leu Gly Leu Phe Asp Ala Val
225                 230                 235                 240 
Tyr Ala Ser Asp Arg Ala Thr Phe His Thr Pro Phe Ser His Leu Gly
                245                 250                 255     
Gln Ser Pro Glu Gly Cys Ser Ser Tyr Thr Phe Pro Lys Ile Met Ser
            260                 265                 270         
Pro Ala Lys Ala Thr Glu Met Leu Ile Phe Gly Lys Lys Leu Thr Ala
        275                 280                 285             
Gly Glu Ala Cys Ala Gln Gly Leu Val Thr Glu Val Phe Pro Asp Ser
    290                 295                 300                 
Thr Phe Gln Lys Glu Val Trp Thr Arg Leu Lys Ala Phe Ala Lys Leu
305                 310                 315                 320 
Pro Pro Asn Ala Leu Arg Ile Ser Lys Glu Val Ile Arg Lys Arg Glu
                325                 330                 335     
Arg Glu Lys Leu His Ala Val Asn Ala Glu Glu Cys Asn Val Leu Gln
            340                 345                 350         
Gly Arg Trp Leu Ser Asp Glu Cys Thr Asn Ala Val Val Asn Phe Leu
        355                 360                 365             
Ser Arg Lys Ser Lys Leu
    370                 


<210> 928
<211> 969
<212> PRT
<213> Homo sapiens

<400> 928
Met Ala Glu Asp Asp Pro Tyr Leu Gly Arg Pro Glu Gln Met Phe His
 1               5                  10                  15      
Leu Asp Pro Ser Leu Thr His Thr Ile Phe Asn Pro Glu Val Phe Gln
            20                  25                  30          
Pro Gln Met Ala Leu Pro Thr Asp Gly Pro Tyr Leu Gln Ile Leu Glu
        35                  40                  45              
Gln Pro Lys Gln Arg Gly Phe Arg Phe Arg Tyr Val Cys Glu Gly Pro
    50                  55                  60                  
Ser His Gly Gly Leu Pro Gly Ala Ser Ser Glu Lys Asn Lys Lys Ser
65                  70                  75                  80  
Tyr Pro Gln Val Lys Ile Cys Asn Tyr Val Gly Pro Ala Lys Val Ile
                85                  90                  95      
Val Gln Leu Val Thr Asn Gly Lys Asn Ile His Leu His Ala His Ser
            100                 105                 110         
Leu Val Gly Lys His Cys Glu Asp Gly Ile Cys Thr Val Thr Ala Gly
        115                 120                 125             
Pro Lys Asp Met Val Val Gly Phe Ala Asn Leu Gly Ile Leu His Val
    130                 135                 140                 
Thr Lys Lys Lys Val Phe Glu Thr Leu Glu Ala Arg Met Thr Glu Ala
145                 150                 155                 160 
Cys Ile Arg Gly Tyr Asn Pro Gly Leu Leu Val His Pro Asp Leu Ala
                165                 170                 175     
Tyr Leu Gln Ala Glu Gly Gly Gly Asp Arg Gln Leu Gly Asp Arg Glu
            180                 185                 190         
Lys Glu Leu Ile Arg Gln Ala Ala Leu Gln Gln Thr Lys Glu Met Asp
        195                 200                 205             
Leu Ser Val Val Arg Leu Met Phe Thr Ala Phe Leu Pro Asp Ser Thr
    210                 215                 220                 
Gly Ser Phe Thr Arg Arg Leu Glu Pro Val Val Ser Asp Ala Ile Tyr
225                 230                 235                 240 
Asp Ser Ser Glu Ala Pro Asn Ala Ser Asn Leu Lys Ile Val Arg Met
                245                 250                 255     
Asp Arg Thr Ala Gly Cys Val Thr Gly Gly Glu Glu Ile Tyr Leu Leu
            260                 265                 270         
Cys Asp Lys Val Gln Lys Asp Asp Ile Gln Ile Arg Phe Tyr Glu Glu
        275                 280                 285             
Glu Glu Asn Gly Gly Val Trp Glu Gly Phe Gly Asp Phe Ser Pro Thr
    290                 295                 300                 
Asp Val His Arg Gln Phe Ala Ile Val Phe Lys Thr Pro Lys Tyr Lys
305                 310                 315                 320 
Asp Ile Asn Ile Thr Lys Pro Ala Ser Val Phe Val Gln Leu Arg Arg
                325                 330                 335     
Lys Ser Asp Leu Glu Thr Ser Glu Pro Lys Pro Phe Leu Tyr Tyr Pro
            340                 345                 350         
Glu Ile Lys Asp Lys Glu Glu Val Gln Arg Lys Arg Gln Lys Leu Met
        355                 360                 365             
Pro Asn Phe Ser Asp Ser Phe Gly Gly Gly Ser Gly Ala Gly Ala Gly
    370                 375                 380                 
Gly Gly Gly Met Phe Gly Ser Gly Gly Gly Gly Gly Gly Thr Gly Ser
385                 390                 395                 400 
Thr Gly Pro Gly Tyr Ser Phe Pro His Tyr Gly Phe Pro Thr Tyr Gly
                405                 410                 415     
Gly Ile Thr Phe His Pro Gly Thr Thr Lys Ser Asn Ala Gly Met Lys
            420                 425                 430         
His Gly Thr Met Asp Thr Glu Ser Lys Lys Asp Pro Glu Gly Cys Asp
        435                 440                 445             
Lys Ser Asp Asp Lys Asn Thr Val Asn Leu Phe Gly Lys Val Ile Glu
    450                 455                 460                 
Thr Thr Glu Gln Asp Gln Glu Pro Ser Glu Ala Thr Val Gly Asn Gly
465                 470                 475                 480 
Glu Val Thr Leu Thr Tyr Ala Thr Gly Thr Lys Glu Glu Ser Ala Gly
                485                 490                 495     
Val Gln Asp Asn Leu Phe Leu Glu Lys Ala Met Gln Leu Ala Lys Arg
            500                 505                 510         
His Ala Asn Ala Leu Phe Asp Tyr Ala Val Thr Gly Asp Val Lys Met
        515                 520                 525             
Leu Leu Ala Val Gln Arg His Leu Thr Ala Val Gln Asp Glu Asn Gly
    530                 535                 540                 
Asp Ser Val Leu His Leu Ala Ser Ser His Leu His Ser Gln Leu Val
545                 550                 555                 560 
Arg Asp Leu Leu Glu Val Thr Ser Gly Leu Ile Ser Asp Asp Ile Ile
                565                 570                 575     
Asn Met Arg Asn Asp Leu Tyr Gln Thr Pro Leu His Leu Ala Val Ile
            580                 585                 590         
Thr Lys Gln Glu Asp Val Val Glu Asp Leu Leu Arg Ala Gly Ala Asp
        595                 600                 605             
Leu Ser Leu Leu Asp Arg Leu Gly Asn Ser Val Leu His Leu Ala Ala
    610                 615                 620                 
Lys Glu Gly His Asp Lys Val Leu Ser Ile Leu Leu Lys His Lys Lys
625                 630                 635                 640 
Ala Ala Leu Leu Leu Asp His Pro Asn Gly Asp Gly Leu Asn Ala Ile
                645                 650                 655     
His Leu Ala Met Met Ser Asn Ser Leu Pro Cys Leu Leu Leu Leu Val
            660                 665                 670         
Ala Ala Gly Ala Asp Val Asn Ala Gln Glu Gln Lys Ser Gly Arg Thr
        675                 680                 685             
Ala Leu His Leu Ala Val Glu His Asp Asn Ile Ser Leu Ala Gly Cys
    690                 695                 700                 
Leu Leu Leu Glu Gly Asp Ala His Val Asp Ser Thr Thr Tyr Asp Gly
705                 710                 715                 720 
Thr Thr Pro Leu His Ile Val Ala Gly Arg Gly Ser Thr Arg Leu Ala
                725                 730                 735     
Ala Leu Leu Lys Ala Ala Gly Ala Asp Pro Leu Val Glu Asn Phe Glu
            740                 745                 750         
Pro Leu Tyr Asp Leu Asp Asp Ser Trp Glu Asn Ala Gly Glu Asp Glu
        755                 760                 765             
Gly Val Val Pro Gly Thr Thr Pro Leu Asp Met Ala Thr Ser Trp Gln
    770                 775                 780                 
Val Phe Asp Ile Leu Asn Gly Lys Pro Tyr Glu Pro Glu Phe Thr Ser
785                 790                 795                 800 
Asp Asp Leu Leu Ala Gln Gly Asp Met Lys Gln Leu Ala Glu Asp Val
                805                 810                 815     
Lys Leu Gln Leu Tyr Lys Leu Leu Glu Ile Pro Asp Pro Asp Lys Asn
            820                 825                 830         
Trp Ala Thr Leu Ala Gln Lys Leu Gly Leu Gly Ile Leu Asn Asn Ala
        835                 840                 845             
Phe Arg Leu Ser Pro Ala Pro Ser Lys Thr Leu Met Asp Asn Tyr Glu
    850                 855                 860                 
Val Ser Gly Gly Thr Ile Arg Glu Leu Val Glu Ala Leu Arg Gln Met
865                 870                 875                 880 
Gly Tyr Thr Glu Ala Ile Glu Val Ile Gln Ala Ala Ser Ser Pro Val
                885                 890                 895     
Lys Thr Thr Ser Gln Ala His Ser Leu Pro Leu Ser Pro Ala Ser Thr
            900                 905                 910         
Arg Gln Gln Ile Asp Glu Leu Arg Asp Ser Asp Ser Val Cys Asp Thr
        915                 920                 925             
Gly Val Glu Thr Ser Phe Arg Lys Leu Ser Phe Thr Glu Ser Leu Thr
    930                 935                 940                 
Ser Gly Ala Ser Leu Leu Thr Leu Asn Lys Met Pro His Asp Tyr Gly
945                 950                 955                 960 
Gln Glu Gly Pro Leu Glu Gly Lys Ile
                965                 


<210> 929
<211> 435
<212> PRT
<213> Homo sapiens

<400> 929
Met Glu Glu Asp Trp Gly Lys Thr Val Ser Glu Lys Val Ile Ser Ala
 1               5                  10                  15      
Tyr Met Ser Leu Pro Lys Lys Gly Lys Pro Gln Gly Arg Glu Val Thr
            20                  25                  30          
Val Leu Ser Ala Phe Leu Val Ser Ser Pro Ser Gln Asp Pro Lys Val
        35                  40                  45              
Ile Ala Leu Gly Thr Gly Thr Lys Cys Val Ser Gly Ser Leu Leu Ser
    50                  55                  60                  
Pro Arg Gly Asp Ile Val Asn Asp Ser His Ala Glu Val Val Ala Arg
65                  70                  75                  80  
Arg Ala Leu Ile Arg Phe Phe Tyr Ser Glu Ile Gln Arg Met Gln Leu
                85                  90                  95      
Thr Ser Gly Lys Ser Asn Glu Ala Lys Arg Gln Arg Ile Asp Ser Glu
            100                 105                 110         
Thr Ser Ser Ile Leu Glu Ser Ala Asp Ser Ser Cys Pro Gly Glu Val
        115                 120                 125             
Lys Tyr Lys Leu Lys Ser Gly Cys Leu Leu His Leu Tyr Ile Ser Gln
    130                 135                 140                 
Leu Pro Cys Gly Tyr Ala Ser Thr Ser Ser Pro Leu Tyr Ala Leu Lys
145                 150                 155                 160 
Lys Ile Pro Ser Thr Gln Val Asp Asp Ser Leu Leu Val Gln Ala Ser
                165                 170                 175     
Asp Ile Cys Ser Ser Arg His Ser Asp Val Pro Glu Ile Gly Ser Asn
            180                 185                 190         
Ser Asn Lys Gly Asn Gly Ser Gln Val Ala Asp Met Val Gln Arg Lys
        195                 200                 205             
Pro Gly Arg Gly Glu Thr Thr Leu Ser Val Ser Cys Ser Asp Lys Ile
    210                 215                 220                 
Ala Arg Trp Asn Val Leu Gly Val Gln Gly Ala Leu Leu Tyr Gln Val
225                 230                 235                 240 
Leu Gln Pro Val Tyr Ile Ser Thr Ile Thr Val Gly Gln Ser Leu His
                245                 250                 255     
Ser Pro Asp Asn Phe Ser Leu Ala Asp His Leu Arg Arg Ser Leu Tyr
            260                 265                 270         
Glu Arg Ile Leu Pro Leu Ser Asp Glu Leu Leu Thr Ser Phe Arg Leu
        275                 280                 285             
Asn Lys Pro Leu Phe Phe Val Ala Pro Val Pro Pro Ser Glu Phe Gln
    290                 295                 300                 
His Ser Glu Thr Ala Gln Ala Thr Leu Thr Cys Gly Leu Val Phe Asn
305                 310                 315                 320 
Thr Leu Pro His Met Thr Cys Val Ser Phe Leu Cys Phe Leu Lys Gly
                325                 330                 335     
Gly Val Ile Tyr Leu Leu Ala Leu Arg Tyr Ser Leu Cys Trp Asn Tyr
            340                 345                 350         
Ser Gly Leu His Glu Val Ile Leu Gly Thr Thr Gly Arg Lys Gln Gly
        355                 360                 365             
Thr Ser Ala Lys Gly Ala Leu Tyr Pro Ser Thr Gln Ser Ser Ile Cys
    370                 375                 380                 
Lys Gln Arg Leu Leu Glu Leu Phe Leu Lys Glu Thr His Gly His Lys
385                 390                 395                 400 
Arg Glu Ser Ser Lys Ser Lys Lys Ser Tyr Arg Glu Leu Lys Val Cys
                405                 410                 415     
Ala Met Leu Ile Leu Phe Cys Ser Phe Asn Met Leu Pro Leu Glu Gln
            420                 425                 430         
Leu Thr Cys
        435 


<210> 930
<211> 19
<212> PRT
<213> Homo sapiens

<400> 930
Cys Ala Ser Ser Pro Ile Pro Gly Arg Arg Asn Thr Gly Glu Leu Phe
 1               5                  10                  15      
Phe Gly Glu
            


<210> 931
<211> 2969
<212> PRT
<213> Homo sapiens

<400> 931
Met Asp Pro Arg Asn Thr Ala Met Leu Gly Leu Gly Ser Asp Ser Glu
 1               5                  10                  15      
Gly Phe Ser Arg Lys Ser Pro Ser Ala Ile Ser Thr Gly Thr Leu Val
            20                  25                  30          
Ser Lys Arg Glu Val Glu Leu Glu Lys Asn Thr Lys Glu Glu Glu Asp
        35                  40                  45              
Leu Arg Lys Arg Asn Arg Glu Arg Asn Ile Glu Ala Gly Lys Asp Asp
    50                  55                  60                  
Gly Leu Thr Asp Ala Gln Gln Gln Phe Ser Val Lys Glu Thr Asn Phe
65                  70                  75                  80  
Ser Glu Gly Asn Leu Lys Leu Lys Ile Gly Leu Gln Ala Lys Arg Thr
                85                  90                  95      
Lys Lys Pro Pro Lys Asn Leu Glu Asn Tyr Val Cys Arg Pro Ala Ile
            100                 105                 110         
Lys Thr Thr Ile Lys His Pro Arg Lys Ala Leu Lys Ser Gly Lys Met
        115                 120                 125             
Thr Asp Glu Lys Asn Glu His Cys Pro Ser Lys Arg Asp Pro Ser Lys
    130                 135                 140                 
Leu Tyr Lys Lys Ala Asp Asp Val Ala Ala Ile Glu Cys Gln Ser Glu
145                 150                 155                 160 
Glu Val Ile Arg Leu His Ser Gln Gly Glu Asn Asn Pro Leu Ser Lys
                165                 170                 175     
Lys Leu Ser Pro Val His Ser Glu Met Ala Asp Tyr Ile Asn Ala Thr
            180                 185                 190         
Pro Ser Thr Leu Leu Gly Ser Arg Asp Pro Asp Leu Lys Asp Arg Ala
        195                 200                 205             
Leu Leu Asn Gly Gly Thr Ser Val Thr Glu Lys Leu Ala Gln Leu Ile
    210                 215                 220                 
Ala Thr Cys Pro Pro Ser Lys Ser Ser Lys Thr Lys Pro Lys Lys Leu
225                 230                 235                 240 
Gly Thr Gly Thr Thr Ala Gly Leu Val Ser Lys Asp Leu Ile Arg Lys
                245                 250                 255     
Ala Gly Val Gly Ser Val Ala Gly Ile Ile His Lys Asp Leu Ile Lys
            260                 265                 270         
Lys Pro Thr Ile Ser Thr Ala Val Gly Leu Val Thr Lys Asp Pro Gly
        275                 280                 285             
Lys Lys Pro Val Phe Asn Ala Ala Val Gly Leu Val Asn Lys Asp Ser
    290                 295                 300                 
Val Lys Lys Leu Gly Thr Gly Thr Thr Ala Val Phe Ile Asn Lys Asn
305                 310                 315                 320 
Leu Gly Lys Lys Pro Gly Thr Ile Thr Thr Val Gly Leu Leu Ser Lys
                325                 330                 335     
Asp Ser Gly Lys Lys Leu Gly Ile Gly Ile Val Pro Gly Leu Val His
            340                 345                 350         
Lys Glu Ser Gly Lys Lys Leu Gly Leu Gly Thr Val Val Gly Leu Val
        355                 360                 365             
Asn Lys Asp Leu Gly Lys Lys Leu Gly Ser Thr Val Gly Leu Val Ala
    370                 375                 380                 
Lys Asp Cys Ala Lys Lys Ile Val Ala Ser Ser Ala Met Gly Leu Val
385                 390                 395                 400 
Asn Lys Asp Ile Gly Lys Lys Leu Met Ser Cys Pro Leu Ala Gly Leu
                405                 410                 415     
Ile Ser Lys Asp Ala Ile Asn Leu Lys Ala Glu Ala Leu Leu Pro Thr
            420                 425                 430         
Gln Glu Pro Leu Lys Ala Ser Cys Ser Thr Asn Ile Asn Asn Gln Glu
        435                 440                 445             
Ser Gln Glu Leu Ser Glu Ser Leu Lys Asp Ser Ala Thr Ser Lys Thr
    450                 455                 460                 
Phe Glu Lys Asn Val Val Arg Gln Asn Lys Glu Ser Ile Leu Glu Lys
465                 470                 475                 480 
Phe Ser Val Arg Lys Glu Ile Ile Asn Leu Glu Lys Glu Met Phe Asn
                485                 490                 495     
Glu Gly Thr Cys Ile Gln Gln Asp Ser Phe Ser Ser Ser Glu Lys Gly
            500                 505                 510         
Ser Tyr Glu Thr Ser Lys His Glu Lys Gln Pro Pro Val Tyr Cys Thr
        515                 520                 525             
Ser Pro Asp Phe Lys Met Gly Gly Ala Ser Asp Val Ser Thr Ala Lys
    530                 535                 540                 
Ser Pro Phe Ser Ala Val Gly Glu Ser Asn Leu Pro Ser Pro Ser Pro
545                 550                 555                 560 
Thr Val Ser Val Asn Pro Leu Thr Arg Ser Pro Pro Glu Thr Ser Ser
                565                 570                 575     
Gln Leu Ala Pro Asn Pro Leu Leu Leu Ser Ser Thr Thr Glu Leu Ile
            580                 585                 590         
Glu Glu Ile Ser Glu Ser Val Gly Lys Asn Gln Phe Thr Ser Glu Ser
        595                 600                 605             
Thr His Leu Asn Val Gly His Arg Ser Val Gly His Ser Ile Ser Ile
    610                 615                 620                 
Glu Cys Lys Gly Ile Asp Lys Glu Val Asn Asp Ser Lys Thr Thr His
625                 630                 635                 640 
Ile Asp Ile Pro Arg Ile Ser Ser Ser Leu Gly Lys Lys Pro Ser Leu
                645                 650                 655     
Thr Ser Glu Ser Ser Ile His Thr Ile Thr Pro Ser Val Val Asn Phe
            660                 665                 670         
Thr Ser Leu Phe Ser Asn Lys Pro Phe Leu Lys Leu Gly Ala Val Ser
        675                 680                 685             
Ala Ser Asp Lys His Cys Gln Val Ala Glu Ser Leu Ser Thr Ser Leu
    690                 695                 700                 
Gln Ser Lys Pro Leu Lys Lys Arg Lys Gly Arg Lys Pro Arg Trp Thr
705                 710                 715                 720 
Lys Val Val Ala Arg Ser Thr Cys Arg Ser Pro Lys Gly Leu Glu Leu
                725                 730                 735     
Glu Arg Ser Glu Leu Phe Lys Asn Val Ser Cys Ser Ser Leu Ser Asn
            740                 745                 750         
Ser Asn Ser Glu Pro Ala Lys Phe Met Lys Asn Ile Gly Pro Pro Ser
        755                 760                 765             
Phe Val Asp His Asp Phe Leu Lys Arg Arg Leu Pro Lys Leu Ser Lys
    770                 775                 780                 
Ser Thr Ala Pro Ser Leu Ala Leu Leu Ala Asp Ser Glu Lys Pro Ser
785                 790                 795                 800 
His Lys Ser Phe Ala Thr His Lys Leu Ser Ser Ser Met Cys Val Ser
                805                 810                 815     
Ser Asp Leu Leu Ser Asp Ile Tyr Lys Pro Lys Arg Gly Arg Pro Lys
            820                 825                 830         
Ser Lys Glu Met Pro Gln Leu Glu Gly Pro Pro Lys Arg Thr Leu Lys
        835                 840                 845             
Ile Pro Ala Ser Lys Val Phe Ser Leu Gln Ser Lys Glu Glu Gln Glu
    850                 855                 860                 
Pro Pro Ile Leu Gln Pro Glu Ile Glu Ile Pro Ser Phe Lys Gln Gly
865                 870                 875                 880 
Leu Ser Val Ser Pro Phe Pro Lys Lys Arg Gly Arg Pro Lys Arg Gln
                885                 890                 895     
Met Arg Ser Pro Val Lys Met Lys Pro Pro Val Leu Ser Val Ala Pro
            900                 905                 910         
Phe Val Ala Thr Glu Ser Pro Ser Lys Leu Glu Ser Glu Ser Asp Asn
        915                 920                 925             
His Arg Ser Ser Ser Asp Phe Phe Glu Ser Glu Asp Gln Leu Gln Asp
    930                 935                 940                 
Pro Asp Asp Leu Asp Asp Ser His Arg Pro Ser Val Cys Ser Met Ser
945                 950                 955                 960 
Asp Leu Glu Met Glu Pro Asp Lys Lys Ile Thr Lys Arg Asn Asn Gly
                965                 970                 975     
Gln Leu Met Lys Thr Ile Ile Arg Lys Ile Asn Lys Met Lys Thr Leu
            980                 985                 990         
Lys Arg Lys Lys Leu Leu Asn Gln Ile Leu Ser Ser Ser Val Glu Ser
        995                 1000                1005            
Ser Asn Lys Gly Lys Val Gln Ser Lys Leu His Asn Thr Val Ser Ser
    1010                1015                1020                
Leu Ala Ala Thr Phe Gly Ser Lys Leu Gly Gln Gln Ile Asn Val Ser
1025                1030                1035                1040
Lys Lys Gly Thr Ile Tyr Ile Gly Lys Arg Arg Gly Arg Lys Pro Lys
                1045                1050                1055    
Thr Val Leu Asn Gly Ile Leu Ser Gly Ser Pro Thr Ser Leu Ala Val
            1060                1065                1070        
Leu Glu Gln Thr Ala Gln Gln Ala Ala Gly Ser Ala Leu Gly Gln Ile
        1075                1080                1085            
Leu Pro Pro Leu Leu Pro Ser Ser Ala Ser Ser Ser Glu Ile Leu Pro
    1090                1095                1100                
Ser Pro Ile Cys Ser Gln Ser Ser Gly Thr Ser Gly Gly Gln Ser Pro
1105                1110                1115                1120
Val Ser Ser Asp Ala Gly Phe Val Glu Pro Ser Ser Val Pro Tyr Leu
                1125                1130                1135    
His Leu His Ser Arg Gln Gly Ser Met Ile Gln Thr Leu Ala Met Lys
            1140                1145                1150        
Lys Ala Ser Lys Gly Arg Arg Arg Leu Ser Pro Pro Thr Leu Leu Pro
        1155                1160                1165            
Asn Ser Pro Ser His Leu Ser Glu Leu Thr Ser Leu Lys Glu Ala Thr
    1170                1175                1180                
Pro Ser Pro Ile Ser Glu Ser His Ser Asp Glu Thr Ile Pro Ser Asp
1185                1190                1195                1200
Ser Gly Ile Gly Thr Asp Asn Asn Ser Thr Ser Asp Arg Ala Glu Lys
                1205                1210                1215    
Phe Cys Gly Gln Lys Lys Arg Arg His Ser Phe Glu His Val Ser Leu
            1220                1225                1230        
Ile Pro Pro Glu Thr Ser Thr Val Leu Ser Ser Leu Lys Glu Lys His
        1235                1240                1245            
Lys His Lys Cys Lys Arg Arg Asn His Asp Tyr Leu Ser Tyr Asp Lys
    1250                1255                1260                
Met Lys Arg Gln Lys Arg Lys Arg Lys Lys Lys Tyr Pro Gln Leu Arg
1265                1270                1275                1280
Asn Arg Gln Asp Pro Asp Phe Ile Ala Glu Leu Glu Glu Leu Ile Ser
                1285                1290                1295    
Arg Leu Ser Glu Ile Arg Ile Thr His Arg Ser His His Phe Ile Pro
            1300                1305                1310        
Arg Asp Leu Leu Pro Thr Ile Phe Arg Ile Asn Phe Asn Ser Phe Tyr
        1315                1320                1325            
Thr His Pro Ser Phe Pro Leu Asp Pro Leu His Tyr Ile Arg Lys Pro
    1330                1335                1340                
Asp Leu Lys Lys Lys Arg Gly Arg Pro Pro Lys Met Arg Glu Ala Met
1345                1350                1355                1360
Ala Glu Met Pro Phe Met His Ser Leu Ser Phe Pro Leu Ser Ser Thr
                1365                1370                1375    
Gly Phe Tyr Pro Ser Tyr Gly Met Pro Tyr Ser Pro Ser Pro Leu Thr
            1380                1385                1390        
Ala Ala Pro Ile Gly Leu Gly Tyr Tyr Gly Arg Tyr Pro Pro Thr Leu
        1395                1400                1405            
Tyr Pro Pro Pro Pro Ser Pro Ser Phe Thr Thr Pro Leu Pro Pro Pro
    1410                1415                1420                
Ser Tyr Met His Ala Gly His Leu Leu Leu Asn Pro Ala Lys Tyr His
1425                1430                1435                1440
Lys Lys Lys His Lys Leu Leu Arg Gln Glu Ala Phe Leu Thr Thr Ser
                1445                1450                1455    
Arg Thr Pro Leu Leu Ser Met Ser Thr Tyr Pro Ser Val Pro Pro Glu
            1460                1465                1470        
Met Ala Tyr Gly Trp Met Val Glu His Lys His Arg His Arg His Lys
        1475                1480                1485            
His Arg Glu His Arg Ser Ser Glu Gln Pro Gln Val Ser Met Asp Thr
    1490                1495                1500                
Gly Ser Ser Arg Ser Val Leu Glu Ser Leu Lys Arg Tyr Arg Phe Gly
1505                1510                1515                1520
Lys Asp Ala Val Gly Glu Arg Tyr Lys His Lys Glu Lys His Arg Cys
                1525                1530                1535    
His Met Ser Cys Pro His Leu Ser Pro Ser Lys Ser Leu Ile Asn Arg
            1540                1545                1550        
Glu Glu Gln Trp Val His Arg Glu Pro Ser Glu Ser Ser Pro Leu Ala
        1555                1560                1565            
Leu Gly Leu Gln Thr Pro Leu Gln Ile Asp Cys Ser Glu Ser Ser Pro
    1570                1575                1580                
Ser Leu Ser Leu Gly Gly Phe Thr Pro Asn Ser Glu Pro Ala Ser Ser
1585                1590                1595                1600
Asp Glu His Thr Asn Leu Phe Thr Ser Ala Ile Gly Ser Cys Arg Val
                1605                1610                1615    
Ser Asn Pro Asn Ser Ser Gly Arg Lys Lys Leu Thr Asp Ser Pro Gly
            1620                1625                1630        
Leu Phe Ser Ala Gln Asp Thr Ser Leu Asn Arg Leu His Arg Lys Glu
        1635                1640                1645            
Ser Leu Pro Ser Asn Glu Arg Ala Val Gln Thr Leu Ala Gly Ser Gln
    1650                1655                1660                
Pro Thr Ser Asp Lys Pro Ser Gln Arg Pro Ser Glu Ser Thr Asn Cys
1665                1670                1675                1680
Ser Pro Thr Arg Lys Arg Ser Ser Ser Glu Ser Thr Ser Ser Thr Val
                1685                1690                1695    
Asn Gly Val Pro Ser Arg Ser Pro Arg Leu Val Ala Ser Gly Asp Asp
            1700                1705                1710        
Ser Val Asp Ser Leu Leu Gln Arg Met Val Gln Asn Glu Asp Gln Glu
        1715                1720                1725            
Pro Met Glu Lys Ser Ile Asp Ala Val Ile Ala Thr Ala Ser Ala Pro
    1730                1735                1740                
Pro Ser Ser Ser Pro Gly Arg Ser His Ser Lys Asp Arg Thr Leu Gly
1745                1750                1755                1760
Lys Pro Asp Ser Leu Leu Val Pro Ala Val Ala Ser Asp Ser Cys Asn
                1765                1770                1775    
Asn Ser Ile Ser Leu Leu Ser Glu Lys Leu Thr Ser Ser Cys Ser Pro
            1780                1785                1790        
His His Ile Lys Arg Ser Val Val Glu Ala Met Gln Arg Gln Ala Arg
        1795                1800                1805            
Lys Met Cys Asn Tyr Asp Lys Ile Leu Ala Thr Lys Lys Asn Leu Asp
    1810                1815                1820                
His Val Asn Lys Ile Leu Lys Ala Lys Lys Leu Gln Arg Gln Ala Arg
1825                1830                1835                1840
Thr Gly Asn Asn Phe Val Lys Arg Arg Pro Gly Arg Pro Arg Lys Cys
                1845                1850                1855    
Pro Leu Gln Ala Val Val Ser Met Gln Ala Phe Gln Ala Ala Gln Phe
            1860                1865                1870        
Val Asn Pro Glu Leu Asn Arg Asp Glu Glu Gly Ala Ala Leu His Leu
        1875                1880                1885            
Ser Pro Asp Thr Val Thr Asp Val Ile Glu Ala Val Val Gln Ser Val
    1890                1895                1900                
Asn Leu Asn Pro Glu His Lys Lys Gly Leu Lys Arg Lys Gly Trp Leu
1905                1910                1915                1920
Leu Glu Glu Gln Thr Arg Lys Lys Gln Lys Pro Leu Pro Glu Glu Glu
                1925                1930                1935    
Glu Gln Glu Asn Asn Lys Ser Phe Asn Glu Ala Pro Val Glu Ile Pro
            1940                1945                1950        
Ser Pro Ser Glu Thr Pro Ala Lys Pro Ser Glu Pro Glu Ser Thr Leu
        1955                1960                1965            
Gln Pro Val Leu Ser Leu Ile Pro Arg Glu Lys Lys Pro Pro Arg Pro
    1970                1975                1980                
Pro Lys Lys Lys Tyr Gln Lys Ala Gly Leu Tyr Ser Asp Val Tyr Lys
1985                1990                1995                2000
Thr Thr Asp Pro Lys Ser Arg Leu Ile Gln Leu Lys Lys Glu Lys Leu
                2005                2010                2015    
Glu Tyr Thr Pro Gly Glu His Glu Tyr Gly Leu Phe Pro Ala Pro Ile
            2020                2025                2030        
His Val Val Phe Phe Val Ser Gly Lys Tyr Leu Arg Gln Lys Arg Ile
        2035                2040                2045            
Asp Phe Gln Leu Pro Tyr Asp Ile Leu Trp Gln Trp Lys His Asn Gln
    2050                2055                2060                
Leu Tyr Lys Lys Pro Asp Val Pro Leu Tyr Lys Lys Ile Arg Ser Asn
2065                2070                2075                2080
Val Tyr Val Asp Val Lys Pro Leu Ser Gly Tyr Glu Ala Thr Thr Cys
                2085                2090                2095    
Asn Cys Lys Lys Pro Asp Asp Asp Thr Arg Lys Gly Cys Val Asp Asp
            2100                2105                2110        
Cys Leu Asn Arg Met Ile Phe Ala Glu Cys Ser Pro Asn Thr Cys Pro
        2115                2120                2125            
Cys Gly Glu Gln Cys Cys Asn Gln Arg Ile Gln Arg His Glu Trp Val
    2130                2135                2140                
Gln Cys Leu Glu Arg Phe Arg Ala Glu Glu Lys Gly Trp Gly Ile Arg
2145                2150                2155                2160
Thr Lys Glu Pro Leu Lys Ala Gly Gln Phe Ile Ile Glu Tyr Leu Gly
                2165                2170                2175    
Glu Val Val Ser Glu Gln Glu Phe Arg Asn Arg Met Ile Glu Gln Tyr
            2180                2185                2190        
His Asn His Ser Asp His Tyr Cys Leu Asn Leu Asp Ser Gly Met Val
        2195                2200                2205            
Ile Asp Ser Tyr Arg Met Gly Asn Glu Ala Arg Phe Ile Asn His Ser
    2210                2215                2220                
Cys Asp Pro Asn Cys Glu Met Gln Lys Trp Ser Val Asn Gly Val Tyr
2225                2230                2235                2240
Arg Ile Gly Leu Tyr Ala Leu Lys Asp Met Pro Ala Gly Thr Glu Leu
                2245                2250                2255    
Thr Tyr Asp Tyr Asn Phe His Ser Phe Asn Val Glu Lys Gln Gln Leu
            2260                2265                2270        
Cys Lys Cys Gly Phe Glu Lys Cys Arg Gly Ile Ile Gly Gly Lys Ser
        2275                2280                2285            
Gln Arg Val Asn Gly Leu Thr Ser Ser Lys Asn Ser Gln Pro Met Ala
    2290                2295                2300                
Thr His Lys Lys Ser Gly Arg Ser Lys Glu Lys Arg Lys Ser Lys His
2305                2310                2315                2320
Lys Leu Lys Lys Arg Arg Gly His Leu Ser Glu Glu Pro Ser Glu Asn
                2325                2330                2335    
Ile Asn Thr Pro Thr Arg Leu Thr Pro Gln Leu Gln Met Lys Pro Met
            2340                2345                2350        
Ser Asn Arg Glu Arg Asn Phe Val Leu Lys His His Val Phe Leu Val
        2355                2360                2365            
Arg Asn Trp Glu Lys Ile Arg Gln Lys Gln Glu Glu Val Lys His Thr
    2370                2375                2380                
Ser Asp Asn Ile His Ser Ala Ser Leu Tyr Thr Arg Trp Asn Gly Ile
2385                2390                2395                2400
Cys Arg Asp Asp Gly Asn Ile Lys Ser Asp Val Phe Met Thr Gln Phe
                2405                2410                2415    
Ser Ala Leu Gln Thr Ala Arg Ser Val Arg Thr Arg Arg Leu Ala Ala
            2420                2425                2430        
Ala Glu Glu Asn Ile Glu Val Ala Arg Ala Ala Arg Leu Ala Gln Ile
        2435                2440                2445            
Phe Lys Glu Ile Cys Asp Gly Ile Ile Ser Tyr Lys Asp Ser Ser Arg
    2450                2455                2460                
Gln Ala Leu Ala Ala Pro Leu Leu Asn Leu Pro Pro Lys Lys Lys Asn
2465                2470                2475                2480
Ala Asp Tyr Tyr Glu Lys Ile Ser Asp Pro Leu Asp Leu Ile Thr Ile
                2485                2490                2495    
Glu Lys Gln Ile Leu Thr Gly Tyr Tyr Lys Thr Val Glu Ala Phe Asp
            2500                2505                2510        
Ala Asp Met Leu Lys Val Phe Arg Asn Ala Glu Lys Tyr Tyr Gly Arg
        2515                2520                2525            
Lys Ser Pro Val Gly Arg Asp Val Cys Arg Leu Arg Lys Ala Tyr Tyr
    2530                2535                2540                
Asn Ala Arg His Glu Ala Ser Ala Gln Ile Asp Glu Ile Val Gly Glu
2545                2550                2555                2560
Thr Ala Ser Glu Ala Asp Ser Ser Glu Thr Ser Val Ser Glu Lys Glu
                2565                2570                2575    
Asn Gly His Glu Lys Asp Asp Asp Val Ile Arg Cys Ile Cys Gly Leu
            2580                2585                2590        
Tyr Asn Asp Glu Gly Leu Met Ile Gln Cys Asp Lys Cys Met Val Trp
        2595                2600                2605            
Gln His Cys Asp Cys Met Gly Val Asn Ser Asp Val Glu His Tyr Leu
    2610                2615                2620                
Cys Glu Gln Cys Asp Pro Arg Pro Val Asp Arg Glu Val Pro Met Ile
2625                2630                2635                2640
Pro Arg Pro His Tyr Ala Gln Pro Gly Cys Val Tyr Phe Ile Cys Leu
                2645                2650                2655    
Leu Arg Asp Asp Leu Leu Leu Arg Gln Gly Asp Cys Val Tyr Leu Met
            2660                2665                2670        
Arg Asp Ser Arg Arg Thr Pro Asp Gly His Pro Val Arg Gln Ser Tyr
        2675                2680                2685            
Arg Leu Leu Ser His Ile Asn Arg His Lys Leu Asp Ile Phe Arg Ile
    2690                2695                2700                
Glu Lys Leu Trp Lys Asn Glu Lys Glu Glu Arg Phe Ala Phe Gly His
2705                2710                2715                2720
His Tyr Phe Arg Pro His Glu Thr His His Ser Pro Ser Arg Arg Phe
                2725                2730                2735    
Tyr His Asn Glu Leu Phe Arg Val Pro Leu Tyr Glu Ile Ile Pro Leu
            2740                2745                2750        
Glu Ala Val Val Gly Thr Cys Cys Val Leu Asp Leu Tyr Thr Tyr Cys
        2755                2760                2765            
Lys Gly Arg Pro Lys Gly Val Lys Glu Gln Asp Val Tyr Ile Cys Asp
    2770                2775                2780                
Tyr Arg Leu Asp Lys Ser Ala His Leu Phe Tyr Lys Ile His Arg Asn
2785                2790                2795                2800
Arg Tyr Pro Val Cys Thr Lys Pro Tyr Ala Phe Asp His Phe Pro Lys
                2805                2810                2815    
Lys Leu Thr Pro Lys Lys Asp Phe Ser Pro His Tyr Val Pro Asp Asn
            2820                2825                2830        
Tyr Lys Arg Asn Gly Gly Arg Ser Ser Trp Lys Ser Glu Arg Ser Lys
        2835                2840                2845            
Pro Pro Leu Lys Asp Leu Gly Gln Glu Asp Asp Ala Leu Pro Leu Ile
    2850                2855                2860                
Glu Glu Val Leu Ala Ser Gln Glu Gln Ala Ala Asn Glu Ile Pro Ser
2865                2870                2875                2880
Leu Glu Glu Pro Glu Arg Glu Gly Ala Thr Ala Asn Val Ser Glu Gly
                2885                2890                2895    
Glu Lys Lys Thr Glu Glu Ser Ser Gln Glu Pro Gln Ser Thr Cys Thr
            2900                2905                2910        
Pro Glu Glu Arg Arg His Asn Gln Arg Glu Arg Leu Asn Gln Ile Leu
        2915                2920                2925            
Leu Asn Leu Leu Glu Lys Ile Pro Gly Lys Asn Ala Ile Asp Val Thr
    2930                2935                2940                
Tyr Leu Leu Glu Glu Gly Ser Gly Arg Lys Leu Arg Arg Arg Thr Leu
2945                2950                2955                2960
Phe Ile Pro Glu Asn Ser Phe Arg Lys
                2965                


<210> 932
<211> 2969
<212> PRT
<213> Homo sapiens

<400> 932
Met Asp Pro Arg Asn Thr Ala Met Leu Gly Leu Gly Ser Asp Ser Glu
 1               5                  10                  15      
Gly Phe Ser Arg Lys Ser Pro Ser Ala Ile Ser Thr Gly Thr Leu Val
            20                  25                  30          
Ser Lys Arg Glu Val Glu Leu Glu Lys Asn Thr Lys Glu Glu Glu Asp
        35                  40                  45              
Leu Arg Lys Arg Asn Arg Glu Arg Asn Ile Glu Ala Gly Lys Asp Asp
    50                  55                  60                  
Gly Leu Thr Asp Ala Gln Gln Gln Phe Ser Val Lys Glu Thr Asn Phe
65                  70                  75                  80  
Ser Glu Gly Asn Leu Lys Leu Lys Ile Gly Leu Gln Ala Lys Arg Thr
                85                  90                  95      
Lys Lys Pro Pro Lys Asn Leu Glu Asn Tyr Val Cys Arg Pro Ala Ile
            100                 105                 110         
Lys Thr Thr Ile Lys His Pro Arg Lys Ala Leu Lys Ser Gly Lys Met
        115                 120                 125             
Thr Asp Glu Lys Asn Glu His Cys Pro Ser Lys Arg Asp Pro Ser Lys
    130                 135                 140                 
Leu Tyr Lys Lys Ala Asp Asp Val Ala Ala Ile Glu Cys Gln Ser Glu
145                 150                 155                 160 
Glu Val Ile Arg Leu His Ser Gln Gly Glu Asn Asn Pro Leu Ser Lys
                165                 170                 175     
Lys Leu Ser Pro Val His Ser Glu Met Ala Asp Tyr Ile Asn Ala Thr
            180                 185                 190         
Pro Ser Thr Leu Leu Gly Ser Arg Asp Pro Asp Leu Lys Asp Arg Ala
        195                 200                 205             
Leu Leu Asn Gly Gly Thr Ser Val Thr Glu Lys Leu Ala Gln Leu Ile
    210                 215                 220                 
Ala Thr Cys Pro Pro Ser Lys Ser Ser Lys Thr Lys Pro Lys Lys Leu
225                 230                 235                 240 
Gly Thr Gly Thr Thr Ala Gly Leu Val Ser Lys Asp Leu Ile Arg Lys
                245                 250                 255     
Ala Gly Val Gly Ser Val Ala Gly Ile Ile His Lys Asp Leu Ile Lys
            260                 265                 270         
Lys Pro Thr Ile Ser Thr Ala Val Gly Leu Val Thr Lys Asp Pro Gly
        275                 280                 285             
Lys Lys Pro Val Phe Asn Ala Ala Val Gly Leu Val Asn Lys Asp Ser
    290                 295                 300                 
Val Lys Lys Leu Gly Thr Gly Thr Thr Ala Val Phe Ile Asn Lys Asn
305                 310                 315                 320 
Leu Gly Lys Lys Pro Gly Thr Ile Thr Thr Val Gly Leu Leu Ser Lys
                325                 330                 335     
Asp Ser Gly Lys Lys Leu Gly Ile Gly Ile Val Pro Gly Leu Val His
            340                 345                 350         
Lys Glu Ser Gly Lys Lys Leu Gly Leu Gly Thr Val Val Gly Leu Val
        355                 360                 365             
Asn Lys Asp Leu Gly Lys Lys Leu Gly Ser Thr Val Gly Leu Val Ala
    370                 375                 380                 
Lys Asp Cys Ala Lys Lys Ile Val Ala Ser Ser Ala Met Gly Leu Val
385                 390                 395                 400 
Asn Lys Asp Ile Gly Lys Lys Leu Met Ser Cys Pro Leu Ala Gly Leu
                405                 410                 415     
Ile Ser Lys Asp Ala Ile Asn Leu Lys Ala Glu Ala Leu Leu Pro Thr
            420                 425                 430         
Gln Glu Pro Leu Lys Ala Ser Cys Ser Thr Asn Ile Asn Asn Gln Glu
        435                 440                 445             
Ser Gln Glu Leu Ser Glu Ser Leu Lys Asp Ser Ala Thr Ser Lys Thr
    450                 455                 460                 
Phe Glu Lys Asn Val Val Arg Gln Asn Lys Glu Ser Ile Leu Glu Lys
465                 470                 475                 480 
Phe Ser Val Arg Lys Glu Ile Ile Asn Leu Glu Lys Glu Met Phe Asn
                485                 490                 495     
Glu Gly Thr Cys Ile Gln Gln Asp Ser Phe Ser Ser Ser Glu Lys Gly
            500                 505                 510         
Ser Tyr Glu Thr Ser Lys His Glu Lys Gln Pro Pro Val Tyr Cys Thr
        515                 520                 525             
Ser Pro Asp Phe Lys Met Gly Gly Ala Ser Asp Val Ser Thr Ala Lys
    530                 535                 540                 
Ser Pro Phe Ser Ala Val Gly Glu Ser Asn Leu Pro Ser Pro Ser Pro
545                 550                 555                 560 
Thr Val Ser Val Asn Pro Leu Thr Arg Ser Pro Pro Glu Thr Ser Ser
                565                 570                 575     
Gln Leu Ala Pro Asn Pro Leu Leu Leu Ser Ser Thr Thr Glu Leu Ile
            580                 585                 590         
Glu Glu Ile Ser Glu Ser Val Gly Lys Asn Gln Phe Thr Ser Glu Ser
        595                 600                 605             
Thr His Leu Asn Val Gly His Arg Ser Val Gly His Ser Ile Ser Ile
    610                 615                 620                 
Glu Cys Lys Gly Ile Asp Lys Glu Val Asn Asp Ser Lys Thr Thr His
625                 630                 635                 640 
Ile Asp Ile Pro Arg Ile Ser Ser Ser Leu Gly Lys Lys Pro Ser Leu
                645                 650                 655     
Thr Ser Glu Ser Ser Ile His Thr Ile Thr Pro Ser Val Val Asn Phe
            660                 665                 670         
Thr Ser Leu Phe Ser Asn Lys Pro Phe Leu Lys Leu Gly Ala Val Ser
        675                 680                 685             
Ala Ser Asp Lys His Cys Gln Val Ala Glu Ser Leu Ser Thr Ser Leu
    690                 695                 700                 
Gln Ser Lys Pro Leu Lys Lys Arg Lys Gly Arg Lys Pro Arg Trp Thr
705                 710                 715                 720 
Lys Val Val Ala Arg Ser Thr Cys Arg Ser Pro Lys Gly Leu Glu Leu
                725                 730                 735     
Glu Arg Ser Glu Leu Phe Lys Asn Val Ser Cys Ser Ser Leu Ser Asn
            740                 745                 750         
Ser Asn Ser Glu Pro Ala Lys Phe Met Lys Asn Ile Gly Pro Pro Ser
        755                 760                 765             
Phe Val Asp His Asp Phe Leu Lys Arg Arg Leu Pro Lys Leu Ser Lys
    770                 775                 780                 
Ser Thr Ala Pro Ser Leu Ala Leu Leu Ala Asp Ser Glu Lys Pro Ser
785                 790                 795                 800 
His Lys Ser Phe Ala Thr His Lys Leu Ser Ser Ser Met Cys Val Ser
                805                 810                 815     
Ser Asp Leu Leu Ser Asp Ile Tyr Lys Pro Lys Arg Gly Arg Pro Lys
            820                 825                 830         
Ser Lys Glu Met Pro Gln Leu Glu Gly Pro Pro Lys Arg Thr Leu Lys
        835                 840                 845             
Ile Pro Ala Ser Lys Val Phe Ser Leu Gln Ser Lys Glu Glu Gln Glu
    850                 855                 860                 
Pro Pro Ile Leu Gln Pro Glu Ile Glu Ile Pro Ser Phe Lys Gln Gly
865                 870                 875                 880 
Leu Ser Val Ser Pro Phe Pro Lys Lys Arg Gly Arg Pro Lys Arg Gln
                885                 890                 895     
Met Arg Ser Pro Val Lys Met Lys Pro Pro Val Leu Ser Val Ala Pro
            900                 905                 910         
Phe Val Ala Thr Glu Ser Pro Ser Lys Leu Glu Ser Glu Ser Asp Asn
        915                 920                 925             
His Arg Ser Ser Ser Asp Phe Phe Glu Ser Glu Asp Gln Leu Gln Asp
    930                 935                 940                 
Pro Asp Asp Leu Asp Asp Ser His Arg Pro Ser Val Cys Ser Met Ser
945                 950                 955                 960 
Asp Leu Glu Met Glu Pro Asp Lys Lys Ile Thr Lys Arg Asn Asn Gly
                965                 970                 975     
Gln Leu Met Lys Thr Ile Ile Arg Lys Ile Asn Lys Met Lys Thr Leu
            980                 985                 990         
Lys Arg Lys Lys Leu Leu Asn Gln Ile Leu Ser Ser Ser Val Glu Ser
        995                 1000                1005            
Ser Asn Lys Gly Lys Val Gln Ser Lys Leu His Asn Thr Val Ser Ser
    1010                1015                1020                
Leu Ala Ala Thr Phe Gly Ser Lys Leu Gly Gln Gln Ile Asn Val Ser
1025                1030                1035                1040
Lys Lys Gly Thr Ile Tyr Ile Gly Lys Arg Arg Gly Arg Lys Pro Lys
                1045                1050                1055    
Thr Val Leu Asn Gly Ile Leu Ser Gly Ser Pro Thr Ser Leu Ala Val
            1060                1065                1070        
Leu Glu Gln Thr Ala Gln Gln Ala Ala Gly Ser Ala Leu Gly Gln Ile
        1075                1080                1085            
Leu Pro Pro Leu Leu Pro Ser Ser Ala Ser Ser Ser Glu Ile Leu Pro
    1090                1095                1100                
Ser Pro Ile Cys Ser Gln Ser Ser Gly Thr Ser Gly Gly Gln Ser Pro
1105                1110                1115                1120
Val Ser Ser Asp Ala Gly Phe Val Glu Pro Ser Ser Val Pro Tyr Leu
                1125                1130                1135    
His Leu His Ser Arg Gln Gly Ser Met Ile Gln Thr Leu Ala Met Lys
            1140                1145                1150        
Lys Ala Ser Lys Gly Arg Arg Arg Leu Ser Pro Pro Thr Leu Leu Pro
        1155                1160                1165            
Asn Ser Pro Ser His Leu Ser Glu Leu Thr Ser Leu Lys Glu Ala Thr
    1170                1175                1180                
Pro Ser Pro Ile Ser Glu Ser His Ser Asp Glu Thr Ile Pro Ser Asp
1185                1190                1195                1200
Ser Gly Ile Gly Thr Asp Asn Asn Ser Thr Ser Asp Arg Ala Glu Lys
                1205                1210                1215    
Phe Cys Gly Gln Lys Lys Arg Arg His Ser Phe Glu His Val Ser Leu
            1220                1225                1230        
Ile Pro Pro Glu Thr Ser Thr Val Leu Ser Ser Leu Lys Glu Lys His
        1235                1240                1245            
Lys His Lys Cys Lys Arg Arg Asn His Asp Tyr Leu Ser Tyr Asp Lys
    1250                1255                1260                
Met Lys Arg Gln Lys Arg Lys Arg Lys Lys Lys Tyr Pro Gln Leu Arg
1265                1270                1275                1280
Asn Arg Gln Asp Pro Asp Phe Ile Ala Glu Leu Glu Glu Leu Ile Ser
                1285                1290                1295    
Arg Leu Ser Glu Ile Arg Ile Thr His Arg Ser His His Phe Ile Pro
            1300                1305                1310        
Arg Asp Leu Leu Pro Thr Ile Phe Arg Ile Asn Phe Asn Ser Phe Tyr
        1315                1320                1325            
Thr His Pro Ser Phe Pro Leu Asp Pro Leu His Tyr Ile Arg Lys Pro
    1330                1335                1340                
Asp Leu Lys Lys Lys Arg Gly Arg Pro Pro Lys Met Arg Glu Ala Met
1345                1350                1355                1360
Ala Glu Met Pro Phe Met His Ser Leu Ser Phe Pro Leu Ser Ser Thr
                1365                1370                1375    
Gly Phe Tyr Pro Ser Tyr Gly Met Pro Tyr Ser Pro Ser Pro Leu Thr
            1380                1385                1390        
Ala Ala Pro Ile Gly Leu Gly Tyr Tyr Gly Arg Tyr Pro Pro Thr Leu
        1395                1400                1405            
Tyr Pro Pro Pro Pro Ser Pro Ser Phe Thr Thr Pro Leu Pro Pro Pro
    1410                1415                1420                
Ser Tyr Met His Ala Gly His Leu Leu Leu Asn Pro Ala Lys Tyr His
1425                1430                1435                1440
Lys Lys Lys His Lys Leu Leu Arg Gln Glu Ala Phe Leu Thr Thr Ser
                1445                1450                1455    
Arg Thr Pro Leu Leu Ser Met Ser Thr Tyr Pro Ser Val Pro Pro Glu
            1460                1465                1470        
Met Ala Tyr Gly Trp Met Val Glu His Lys His Arg His Arg His Lys
        1475                1480                1485            
His Arg Glu His Arg Ser Ser Glu Gln Pro Gln Val Ser Met Asp Thr
    1490                1495                1500                
Gly Ser Ser Arg Ser Val Leu Glu Ser Leu Lys Arg Tyr Arg Phe Gly
1505                1510                1515                1520
Lys Asp Ala Val Gly Glu Arg Tyr Lys His Lys Glu Lys His Arg Cys
                1525                1530                1535    
His Met Ser Cys Pro His Leu Ser Pro Ser Lys Ser Leu Ile Asn Arg
            1540                1545                1550        
Glu Glu Gln Trp Val His Arg Glu Pro Ser Glu Ser Ser Pro Leu Ala
        1555                1560                1565            
Leu Gly Leu Gln Thr Pro Leu Gln Ile Asp Cys Ser Glu Ser Ser Pro
    1570                1575                1580                
Ser Leu Ser Leu Gly Gly Phe Thr Pro Asn Ser Glu Pro Ala Ser Ser
1585                1590                1595                1600
Asp Glu His Thr Asn Leu Phe Thr Ser Ala Ile Gly Ser Cys Arg Val
                1605                1610                1615    
Ser Asn Pro Asn Ser Ser Gly Arg Lys Lys Leu Thr Asp Ser Pro Gly
            1620                1625                1630        
Leu Phe Ser Ala Gln Asp Thr Ser Leu Asn Arg Leu His Arg Lys Glu
        1635                1640                1645            
Ser Leu Pro Ser Asn Glu Arg Ala Val Gln Thr Leu Ala Gly Ser Gln
    1650                1655                1660                
Pro Thr Ser Asp Lys Pro Ser Gln Arg Pro Ser Glu Ser Thr Asn Cys
1665                1670                1675                1680
Ser Pro Thr Arg Lys Arg Ser Ser Ser Glu Ser Thr Ser Ser Thr Val
                1685                1690                1695    
Asn Gly Val Pro Ser Arg Ser Pro Arg Leu Val Ala Ser Gly Asp Asp
            1700                1705                1710        
Ser Val Asp Ser Leu Leu Gln Arg Met Val Gln Asn Glu Asp Gln Glu
        1715                1720                1725            
Pro Met Glu Lys Ser Ile Asp Ala Val Ile Ala Thr Ala Ser Ala Pro
    1730                1735                1740                
Pro Ser Ser Ser Pro Gly Arg Ser His Ser Lys Asp Arg Thr Leu Gly
1745                1750                1755                1760
Lys Pro Asp Ser Leu Leu Val Pro Ala Val Ala Ser Asp Ser Cys Asn
                1765                1770                1775    
Asn Ser Ile Ser Leu Leu Ser Glu Lys Leu Thr Ser Ser Cys Ser Pro
            1780                1785                1790        
His His Ile Lys Arg Ser Val Val Glu Ala Met Gln Arg Gln Ala Arg
        1795                1800                1805            
Lys Met Cys Asn Tyr Asp Lys Ile Leu Ala Thr Lys Lys Asn Leu Asp
    1810                1815                1820                
His Val Asn Lys Ile Leu Lys Ala Lys Lys Leu Gln Arg Gln Ala Arg
1825                1830                1835                1840
Thr Gly Asn Asn Phe Val Lys Arg Arg Pro Gly Arg Pro Arg Lys Cys
                1845                1850                1855    
Pro Leu Gln Ala Val Val Ser Met Gln Ala Phe Gln Ala Ala Gln Phe
            1860                1865                1870        
Val Asn Pro Glu Leu Asn Arg Asp Glu Glu Gly Ala Ala Leu His Leu
        1875                1880                1885            
Ser Pro Asp Thr Val Thr Asp Val Ile Glu Ala Val Val Gln Ser Val
    1890                1895                1900                
Asn Leu Asn Pro Glu His Lys Lys Gly Leu Lys Arg Lys Gly Trp Leu
1905                1910                1915                1920
Leu Glu Glu Gln Thr Arg Lys Lys Gln Lys Pro Leu Pro Glu Glu Glu
                1925                1930                1935    
Glu Gln Glu Asn Asn Lys Ser Phe Asn Glu Ala Pro Val Glu Ile Pro
            1940                1945                1950        
Ser Pro Ser Glu Thr Pro Ala Lys Pro Ser Glu Pro Glu Ser Thr Leu
        1955                1960                1965            
Gln Pro Val Leu Ser Leu Ile Pro Arg Glu Lys Lys Pro Pro Arg Pro
    1970                1975                1980                
Pro Lys Lys Lys Tyr Gln Lys Ala Gly Leu Tyr Ser Asp Val Tyr Lys
1985                1990                1995                2000
Thr Thr Asp Pro Lys Ser Arg Leu Ile Gln Leu Lys Lys Glu Lys Leu
                2005                2010                2015    
Glu Tyr Thr Pro Gly Glu His Glu Tyr Gly Leu Phe Pro Ala Pro Ile
            2020                2025                2030        
His Val Val Phe Phe Val Ser Gly Lys Tyr Leu Arg Gln Lys Arg Ile
        2035                2040                2045            
Asp Phe Gln Leu Pro Tyr Asp Ile Leu Trp Gln Trp Lys His Asn Gln
    2050                2055                2060                
Leu Tyr Lys Lys Pro Asp Val Pro Leu Tyr Lys Lys Ile Arg Ser Asn
2065                2070                2075                2080
Val Tyr Val Asp Val Lys Pro Leu Ser Gly Tyr Glu Ala Thr Thr Cys
                2085                2090                2095    
Asn Cys Lys Lys Pro Asp Asp Asp Thr Arg Lys Gly Cys Val Asp Asp
            2100                2105                2110        
Cys Leu Asn Arg Met Ile Phe Ala Glu Cys Ser Pro Asn Thr Cys Pro
        2115                2120                2125            
Cys Gly Glu Gln Cys Cys Asn Gln Arg Ile Gln Arg His Glu Trp Val
    2130                2135                2140                
Gln Cys Leu Glu Arg Phe Arg Ala Glu Glu Lys Gly Trp Gly Ile Arg
2145                2150                2155                2160
Thr Lys Glu Pro Leu Lys Ala Gly Gln Phe Ile Ile Glu Tyr Leu Gly
                2165                2170                2175    
Glu Val Val Ser Glu Gln Glu Phe Arg Asn Arg Met Ile Glu Gln Tyr
            2180                2185                2190        
His Asn His Ser Asp His Tyr Cys Leu Asn Leu Asp Ser Gly Met Val
        2195                2200                2205            
Ile Asp Ser Tyr Arg Met Gly Asn Glu Ala Arg Phe Ile Asn His Ser
    2210                2215                2220                
Cys Asp Pro Asn Cys Glu Met Gln Lys Trp Ser Val Asn Gly Val Tyr
2225                2230                2235                2240
Arg Ile Gly Leu Tyr Ala Leu Lys Asp Met Pro Ala Gly Thr Glu Leu
                2245                2250                2255    
Thr Tyr Asp Tyr Asn Phe His Ser Phe Asn Val Glu Lys Gln Gln Leu
            2260                2265                2270        
Cys Lys Cys Gly Phe Glu Lys Cys Arg Gly Ile Ile Gly Gly Lys Ser
        2275                2280                2285            
Gln Arg Val Asn Gly Leu Thr Ser Ser Lys Asn Ser Gln Pro Met Ala
    2290                2295                2300                
Thr His Lys Lys Ser Gly Arg Ser Lys Glu Lys Arg Lys Ser Lys His
2305                2310                2315                2320
Lys Leu Lys Lys Arg Arg Gly His Leu Ser Glu Glu Pro Ser Glu Asn
                2325                2330                2335    
Ile Asn Thr Pro Thr Arg Leu Thr Pro Gln Leu Gln Met Lys Pro Met
            2340                2345                2350        
Ser Asn Arg Glu Arg Asn Phe Val Leu Lys His His Val Phe Leu Val
        2355                2360                2365            
Arg Asn Trp Glu Lys Ile Arg Gln Lys Gln Glu Glu Val Lys His Thr
    2370                2375                2380                
Ser Asp Asn Ile His Ser Ala Ser Leu Tyr Thr Arg Trp Asn Gly Ile
2385                2390                2395                2400
Cys Arg Asp Asp Gly Asn Ile Lys Ser Asp Val Phe Met Thr Gln Phe
                2405                2410                2415    
Ser Ala Leu Gln Thr Ala Arg Ser Val Arg Thr Arg Arg Leu Ala Ala
            2420                2425                2430        
Ala Glu Glu Asn Ile Glu Val Ala Arg Ala Ala Arg Leu Ala Gln Ile
        2435                2440                2445            
Phe Lys Glu Ile Cys Asp Gly Ile Ile Ser Tyr Lys Asp Ser Ser Arg
    2450                2455                2460                
Gln Ala Leu Ala Ala Pro Leu Leu Asn Leu Pro Pro Lys Lys Lys Asn
2465                2470                2475                2480
Ala Asp Tyr Tyr Glu Lys Ile Ser Asp Pro Leu Asp Leu Ile Thr Ile
                2485                2490                2495    
Glu Lys Gln Ile Leu Thr Gly Tyr Tyr Lys Thr Val Glu Ala Phe Asp
            2500                2505                2510        
Ala Asp Met Leu Lys Val Phe Arg Asn Ala Glu Lys Tyr Tyr Gly Arg
        2515                2520                2525            
Lys Ser Pro Val Gly Arg Asp Val Cys Arg Leu Arg Lys Ala Tyr Tyr
    2530                2535                2540                
Asn Ala Arg His Glu Ala Ser Ala Gln Ile Asp Glu Ile Val Gly Glu
2545                2550                2555                2560
Thr Ala Ser Glu Ala Asp Ser Ser Glu Thr Ser Val Ser Glu Lys Glu
                2565                2570                2575    
Asn Gly His Glu Lys Asp Asp Asp Val Ile Arg Cys Ile Cys Gly Leu
            2580                2585                2590        
Tyr Asn Asp Glu Gly Leu Met Ile Gln Cys Asp Lys Cys Met Val Trp
        2595                2600                2605            
Gln His Cys Asp Cys Met Gly Val Asn Ser Asp Val Glu His Tyr Leu
    2610                2615                2620                
Cys Glu Gln Cys Asp Pro Arg Pro Val Asp Arg Glu Val Pro Met Ile
2625                2630                2635                2640
Pro Arg Pro His Tyr Ala Gln Pro Gly Cys Val Tyr Phe Ile Cys Leu
                2645                2650                2655    
Leu Arg Asp Asp Leu Leu Leu Arg Gln Gly Asp Cys Val Tyr Leu Met
            2660                2665                2670        
Arg Asp Ser Arg Arg Thr Pro Asp Gly His Pro Val Arg Gln Ser Tyr
        2675                2680                2685            
Arg Leu Leu Ser His Ile Asn Arg His Lys Leu Asp Ile Phe Arg Ile
    2690                2695                2700                
Glu Lys Leu Trp Lys Asn Glu Lys Glu Glu Arg Phe Ala Phe Gly His
2705                2710                2715                2720
His Tyr Phe Arg Pro His Glu Thr His His Ser Pro Ser Arg Arg Phe
                2725                2730                2735    
Tyr His Asn Glu Leu Phe Arg Val Pro Leu Tyr Glu Ile Ile Pro Leu
            2740                2745                2750        
Glu Ala Val Val Gly Thr Cys Cys Val Leu Asp Leu Tyr Thr Tyr Cys
        2755                2760                2765            
Lys Gly Arg Pro Lys Gly Val Lys Glu Gln Asp Val Tyr Ile Cys Asp
    2770                2775                2780                
Tyr Arg Leu Asp Lys Ser Ala His Leu Phe Tyr Lys Ile His Arg Asn
2785                2790                2795                2800
Arg Tyr Pro Val Cys Thr Lys Pro Tyr Ala Phe Asp His Phe Pro Lys
                2805                2810                2815    
Lys Leu Thr Pro Lys Lys Asp Phe Ser Pro His Tyr Val Pro Asp Asn
            2820                2825                2830        
Tyr Lys Arg Asn Gly Gly Arg Ser Ser Trp Lys Ser Glu Arg Ser Lys
        2835                2840                2845            
Pro Pro Leu Lys Asp Leu Gly Gln Glu Asp Asp Ala Leu Pro Leu Ile
    2850                2855                2860                
Glu Glu Val Leu Ala Ser Gln Glu Gln Ala Ala Asn Glu Ile Pro Ser
2865                2870                2875                2880
Leu Glu Glu Pro Glu Arg Glu Gly Ala Thr Ala Asn Val Ser Glu Gly
                2885                2890                2895    
Glu Lys Lys Thr Glu Glu Ser Ser Gln Glu Pro Gln Ser Thr Cys Thr
            2900                2905                2910        
Pro Glu Glu Arg Arg His Asn Gln Arg Glu Arg Leu Asn Gln Ile Leu
        2915                2920                2925            
Leu Asn Leu Leu Glu Lys Ile Pro Gly Lys Asn Ala Ile Asp Val Thr
    2930                2935                2940                
Tyr Leu Leu Glu Glu Gly Ser Gly Arg Lys Leu Arg Arg Arg Thr Leu
2945                2950                2955                2960
Phe Ile Pro Glu Asn Ser Phe Arg Lys
                2965                


<210> 933
<211> 122
<212> PRT
<213> Homo sapiens

<400> 933
Met Gln Val Trp Phe Tyr Ile Cys Lys Ser Ile Asn Val Ile His His
 1               5                  10                  15      
Thr Asn Arg Asn Lys Asp Lys Asn His Leu Ile Ile Ser Ile Asp Ala
            20                  25                  30          
Gly Lys Ser Phe Asp Lys Thr Gln His Arg Phe Met Leu Lys Met Leu
        35                  40                  45              
Asn Lys Leu Ser Ile Glu Ala Thr Tyr Leu Lys Ile Ile Arg Ala Ile
    50                  55                  60                  
Cys Glu Lys Ser Arg Ala Asp Ile Ile Leu Asn Gly Gln Lys Leu Glu
65                  70                  75                  80  
Ala Tyr Pro Leu Lys Thr Ser Arg Trp Gln Gly Cys Pro Leu Ser Thr
                85                  90                  95      
Leu Leu Phe Ser Ile Val Val Glu Val Leu Asp Arg Ala Ile Arg Gln
            100                 105                 110         
Glu Lys Glu Ile Lys Gly Ile Gln Ile Gly
        115                 120         


<210> 934
<211> 389
<212> PRT
<213> Homo sapiens

<400> 934
Met Pro Arg Pro Val Lys Val Ala Ala Val Gly Gly Gln Ser Tyr Leu
 1               5                  10                  15      
Ser Ser Ile Leu Arg Phe Phe Val Lys Ser Leu Ala Asn Met Thr Ser
            20                  25                  30          
Asp Trp Leu Gly Tyr Met Arg Phe Leu Ile Ile Pro Leu Gly Ser His
        35                  40                  45              
Pro Val Ala Lys Tyr Leu Gly Ser Val Asp Ser Lys Tyr Ser Ser Ser
    50                  55                  60                  
Phe Leu Asp Ser Gly Trp Arg Asp Leu Phe Ser Arg Ser Glu Pro Pro
65                  70                  75                  80  
Val Ser Glu Gln Leu Asp Val Ala Gly Arg Val Met Gln Tyr Val Asn
                85                  90                  95      
Gly Ala Ala Thr Thr His Gln Leu Pro Val Ala Glu Ala Met Leu Thr
            100                 105                 110         
Cys Arg His Lys Phe Pro Asp Glu Asp Ser Tyr Gln Lys Phe Ile Pro
        115                 120                 125             
Phe Ile Gly Val Val Lys Val Gly Leu Val Glu Asp Ser Pro Ser Thr
    130                 135                 140                 
Ala Gly Asp Gly Asp Asp Ser Pro Val Val Ser Leu Thr Val Pro Ser
145                 150                 155                 160 
Thr Ser Pro Pro Ser Ser Ser Gly Leu Ser Arg Asp Ala Thr Ala Thr
                165                 170                 175     
Pro Pro Ser Ser Pro Ser Met Ser Ser Ala Leu Ala Ile Val Gly Ser
            180                 185                 190         
Pro Asn Ser Pro Tyr Gly Asp Val Ile Gly Leu Gln Val Asp Tyr Trp
        195                 200                 205             
Leu Gly His Pro Gly Glu Arg Arg Arg Glu Gly Asp Lys Arg Asp Ala
    210                 215                 220                 
Ser Ser Lys Asn Thr Leu Lys Ser Val Phe Arg Ser Val Gln Val Ser
225                 230                 235                 240 
Arg Leu Pro His Ser Gly Glu Ala Gln Leu Ser Gly Thr Met Ala Met
                245                 250                 255     
Thr Val Val Thr Lys Glu Lys Asn Lys Lys Val Pro Thr Ile Phe Leu
            260                 265                 270         
Ser Lys Lys Pro Arg Glu Lys Glu Val Asp Ser Lys Ser Gln Val Ile
        275                 280                 285             
Glu Gly Ile Ser Arg Leu Ile Cys Ser Ser Pro Ser Leu Gly Pro Ser
    290                 295                 300                 
Leu Gly Pro Asp Pro Ser Ser Gln Pro Gly Phe Pro Pro Ala Gly Ser
305                 310                 315                 320 
Phe Pro Pro Cys His Leu Pro Leu Thr Asn Pro Gly Ser Glu Pro Leu
                325                 330                 335     
Ile Pro Asp Arg Pro Cys Ser Gln Glu Trp Leu Arg Thr Gln Gly Pro
            340                 345                 350         
Ser Pro Ala Leu Cys Thr Pro Gln Pro Gly His Leu Arg Pro Thr Ala
        355                 360                 365             
Pro Leu Glu Leu Phe Ser Cys Pro Leu Thr Pro Ser Gln Lys Phe Leu
    370                 375                 380                 
His Arg Thr Ser Phe
385                 


<210> 935
<211> 279
<212> PRT
<213> Homo sapiens

<400> 935
Met Asp Leu Met Asn Gly Gln Ala Ser Ser Val Asn Ile Ala Ala Thr
 1               5                  10                  15      
Ala Ser Glu Lys Ser Ser Ser Ser Glu Ser Leu Ser Asp Lys Gly Ser
            20                  25                  30          
Glu Leu Lys Lys Ser Phe Asp Ala Val Val Phe Asp Val Leu Lys Val
        35                  40                  45              
Thr Pro Glu Glu Tyr Ala Gly Gln Ile Thr Leu Met Asp Val Pro Val
    50                  55                  60                  
Phe Lys Ala Ile Gln Pro Asp Glu Leu Ser Ser Cys Gly Trp Asn Lys
65                  70                  75                  80  
Lys Glu Lys Tyr Ser Ser Ala Pro Asn Ala Val Ala Phe Thr Arg Arg
                85                  90                  95      
Phe Asn His Val Ser Phe Trp Val Val Arg Glu Ile Leu His Ala Gln
            100                 105                 110         
Thr Leu Lys Ile Arg Ala Glu Val Leu Ser His Tyr Ile Lys Thr Ala
        115                 120                 125             
Lys Lys Leu Tyr Glu Leu Asn Asn Leu His Ala Leu Met Ala Val Val
    130                 135                 140                 
Ser Gly Leu Gln Ser Ala Pro Ile Phe Arg Leu Thr Lys Thr Trp Ala
145                 150                 155                 160 
Leu Leu Ser Arg Lys Asp Lys Thr Thr Phe Glu Lys Leu Glu Tyr Val
                165                 170                 175     
Met Ser Lys Glu Asp Asn Tyr Lys Arg Leu Arg Asp Tyr Ile Ser Ser
            180                 185                 190         
Leu Lys Met Thr Pro Cys Ile Pro Tyr Leu Gly Ile Tyr Leu Ser Asp
        195                 200                 205             
Leu Thr Tyr Ile Asp Ser Ala Tyr Pro Ser Thr Gly Ser Ile Leu Glu
    210                 215                 220                 
Asn Glu Gln Arg Ser Asn Leu Met Asn Asn Ile Leu Arg Ile Ile Ser
225                 230                 235                 240 
Asp Leu Gln Gln Ser Cys Glu Tyr Asp Ile Pro Met Leu Pro His Val
                245                 250                 255     
Gln Lys Tyr Leu Asn Ser Val Gln Tyr Ile Glu Glu Leu Gln Lys Phe
            260                 265                 270         
Val Glu Asp Asp Asn Tyr Lys
        275                 


<210> 936
<211> 148
<212> PRT
<213> Homo sapiens

<400> 936
Met Ala Cys Lys Thr Ala Phe Asn Lys Thr Gly Phe Gln Glu Val Phe
 1               5                  10                  15      
Asp Pro Pro His Tyr Glu Leu Phe Ser Leu Arg Asp Lys Glu Ile Ser
            20                  25                  30          
Ala Asp Leu Ala Asp Leu Ser Glu Glu Leu Asp Asn Tyr Gln Lys Met
        35                  40                  45              
Arg Arg Ser Ser Thr Ala Ser Arg Cys Ile His Asp His His Cys Gly
    50                  55                  60                  
Ser Gln Ala Ser Ser Val Lys Gln Ser Arg Thr Asn Leu Ser Ser Met
65                  70                  75                  80  
Glu Leu Pro Phe Arg Asn Asp Phe Ala Gln Pro Gln Pro Met Lys Thr
                85                  90                  95      
Phe Asn Ser Thr Phe Lys Lys Ser Ser Tyr Thr Phe Lys Gln Gly His
            100                 105                 110         
Glu Cys Pro Glu Gln Ala Leu Glu Asp Arg Val Met Glu Glu Ile Pro
        115                 120                 125             
Cys Glu Ile Tyr Val Arg Gly Arg Glu Asp Ser Ala Gln Ala Ser Ile
    130                 135                 140                 
Ser Ile Asp Phe
145             


<210> 937
<211> 138
<212> PRT
<213> Homo sapiens

<400> 937
Met Ala Thr Arg Arg Leu Gly Val Gly Glu Thr Leu Gly Ala Leu Asn
 1               5                  10                  15      
Ala Ala Leu Gly Pro Gly Gly Pro Val Trp Thr Lys Glu Thr Arg Thr
            20                  25                  30          
Arg His Leu Arg Ser Arg Asp Phe Leu Ala Pro His Arg Ala Leu Gln
        35                  40                  45              
Ala Arg Phe Asp Asp Gly Gln Val Pro Glu His Leu Leu His Ala Leu
    50                  55                  60                  
Ala Cys Leu Gln Gly Pro Gly Val Ala Pro Val Leu Arg Cys Ala Pro
65                  70                  75                  80  
Thr Pro Ala Gly Leu Ser Leu Gln Leu Gln Arg Ser Ala Val Phe Glu
                85                  90                  95      
Arg Val Leu Ser Ala Val Ala Ala Tyr Ala Thr Pro Ala Ser Pro Ala
            100                 105                 110         
Ser Leu Gly Gln Arg Val Leu Leu His Cys Pro Ala Leu Arg Ser Ser
        115                 120                 125             
Pro Cys Ala Leu Thr Gly Cys Ala Cys Ala
    130                 135             


<210> 938
<211> 196
<212> PRT
<213> Homo sapiens

<400> 938
Met Ala Ala Leu Lys Ala Leu Val Ser Gly Cys Gly Arg Leu Leu Arg
 1               5                  10                  15      
Gly Leu Leu Ala Gly Pro Ala Ala Thr Ser Trp Ser Arg Leu Pro Ala
            20                  25                  30          
Arg Gly Phe Arg Glu Val Val Glu Thr Gln Glu Gly Lys Thr Thr Ile
        35                  40                  45              
Ile Glu Gly Arg Ile Thr Ala Thr Pro Lys Glu Ser Pro Asn Pro Pro
    50                  55                  60                  
Asn Pro Ser Gly Gln Cys Pro Ile Cys Arg Trp Asn Leu Lys His Lys
65                  70                  75                  80  
Tyr Asn Tyr Asp Asp Val Leu Leu Leu Ser Gln Phe Ile Arg Pro His
                85                  90                  95      
Gly Gly Met Leu Pro Arg Lys Ile Thr Gly Leu Cys Gln Glu Glu His
            100                 105                 110         
Arg Lys Ile Glu Glu Cys Val Lys Met Ala His Arg Ala Gly Leu Leu
        115                 120                 125             
Pro Asn His Arg Pro Arg Leu Pro Glu Gly Val Val Pro Lys Ser Lys
    130                 135                 140                 
Pro Gln Leu Asn Arg Tyr Leu Thr Arg Trp Ala Pro Gly Ser Val Lys
145                 150                 155                 160 
Pro Ile Tyr Lys Lys Gly Pro Arg Trp Asn Arg Val Arg Met Pro Val
                165                 170                 175     
Gly Ser Pro Leu Leu Arg Asp Asn Val Cys Tyr Ser Arg Thr Pro Trp
            180                 185                 190         
Lys Leu Tyr His
        195     


<210> 939
<211> 557
<212> PRT
<213> Homo sapiens

<400> 939
Met Asp Gln Ser Arg Val Leu Leu Trp Val Lys Ala Glu Pro Phe Ile
 1               5                  10                  15      
Val Gly Ala Leu Gln Val Pro Pro Pro Ser Lys Phe Ser Leu His Tyr
            20                  25                  30          
Leu Arg Lys Ile Ser Thr Tyr Val Gln Ile Arg Ala Thr Glu Gly Ala
        35                  40                  45              
Tyr Pro Arg Leu Tyr Trp Ser Thr Trp Arg His Ile Ala Cys Gly Lys
    50                  55                  60                  
Leu Gln Leu Ala Lys Asp Leu Ala Trp Leu Tyr Phe Glu Ile Phe Asp
65                  70                  75                  80  
Ser Leu Ser Met Lys Thr Pro Glu Glu Arg Leu Glu Trp Ser Glu Val
                85                  90                  95      
Leu Ser Asn Cys Met Ser Glu Glu Glu Val Glu Lys Gln Arg Asn Gln
            100                 105                 110         
Leu Ser Val Asp Thr Leu Gln Phe Leu Leu Phe Leu Tyr Ile Gln Gln
        115                 120                 125             
Leu Asn Lys Val Ser Leu Arg Thr Ser Leu Ile Gly Glu Glu Trp Pro
    130                 135                 140                 
Ser Pro Arg Asn Lys Ser Gln Ser Pro Asp Leu Thr Glu Lys Ser Asn
145                 150                 155                 160 
Cys His Asn Lys Asn Trp Asn Asp Tyr Ser His Gln Ala Phe Val Tyr
                165                 170                 175     
Asp His Leu Ser Asp Leu Leu Glu Leu Leu Leu Asp Pro Lys Gln Leu
            180                 185                 190         
Thr Ala Ser Phe His Ser Thr His Ser Ser Leu Val Ser Arg Glu Ala
        195                 200                 205             
Val Val Ala Leu Ser Phe Leu Ile Glu Gly Thr Ile Ser Arg Ala Arg
    210                 215                 220                 
Lys Ile Tyr Pro Leu His Glu Leu Ala Leu Trp Gln Pro Leu His Ala
225                 230                 235                 240 
Asp Ser Gly Phe Ser Lys Ile Ser Lys Thr Phe Ser Phe Tyr Lys Leu
                245                 250                 255     
Glu Thr Trp Leu Arg Ser Cys Leu Thr Gly Asn Pro Phe Gly Thr Ser
            260                 265                 270         
Ala Cys Leu Lys Ser Gly Lys Lys Leu Ala Trp Ala His Gln Val Glu
        275                 280                 285             
Gly Thr Thr Lys Arg Ala Lys Ile Ala Cys Asn Thr His Val Ala Pro
    290                 295                 300                 
Arg Met His Arg Leu Val Val Met Ser Gln Val Tyr Lys Gln Thr Leu
305                 310                 315                 320 
Ala Lys Ser Ser Asp Thr Leu Ala Gly Ala His Val Lys Ile His Arg
                325                 330                 335     
Cys Asn Glu Ser Phe Ile Tyr Leu Leu Ser Pro Leu Arg Ser Val Thr
            340                 345                 350         
Ile Glu Lys Cys Arg Asn Ser Ile Phe Val Leu Gly Pro Val Gly Thr
        355                 360                 365             
Thr Leu His Leu His Ser Cys Asp Asn Val Lys Val Ile Ala Val Cys
    370                 375                 380                 
His Arg Leu Ser Ile Ser Ser Thr Thr Gly Cys Ile Phe His Val Leu
385                 390                 395                 400 
Thr Pro Thr Arg Pro Leu Ile Leu Ser Gly Asn Gln Thr Val Thr Phe
                405                 410                 415     
Ala Pro Phe His Thr His Tyr Pro Met Leu Glu Asp His Met Ala Arg
            420                 425                 430         
Thr Gly Leu Ala Thr Val Pro Asn Tyr Trp Asp Asn Pro Met Val Val
        435                 440                 445             
Cys Arg Glu Asn Ser Asp Thr Arg Val Phe Gln Leu Leu Pro Pro Cys
    450                 455                 460                 
Glu Phe Tyr Val Phe Ile Ile Pro Phe Glu Met Glu Gly Asp Thr Thr
465                 470                 475                 480 
Glu Ile Pro Gly Gly Leu Pro Ser Val Tyr Gln Lys Ala Leu Gly Gln
                485                 490                 495     
Arg Glu Gln Lys Ile Gln Ile Trp Gln Lys Thr Val Lys Glu Ala His
            500                 505                 510         
Leu Thr Lys Asp Gln Arg Lys Gln Phe Gln Val Leu Val Glu Asn Lys
        515                 520                 525             
Phe Tyr Glu Trp Leu Ile Asn Thr Gly His Arg Gln Gln Leu Asp Ser
    530                 535                 540                 
Leu Val Pro Pro Ala Ala Gly Ser Lys Gln Ala Ala Gly
545                 550                 555         


<210> 940
<211> 410
<212> PRT
<213> Homo sapiens

<400> 940
Met Gly Ala Asn Ala Ser Asn Tyr Pro His Ser Cys Ser Pro Arg Val
 1               5                  10                  15      
Gly Gly Asn Ser Gln Ala Gln Gln Thr Phe Ile Gly Thr Ser Ser Tyr
            20                  25                  30          
Ser Gln Gln Gly Tyr Gly Cys Glu Ser Lys Leu Tyr Ser Leu Asp His
        35                  40                  45              
Gly His Glu Lys Pro Gln Asp Lys Lys Lys Arg Thr Ser Gly Leu Ala
    50                  55                  60                  
Thr Leu Lys Lys Lys Phe Ile Lys Arg Arg Lys Ser Asn Arg Ser Ala
65                  70                  75                  80  
Asp His Ala Lys Gln Met Arg Glu Leu Leu Ser Gly Trp Asp Val Arg
                85                  90                  95      
Asp Val Asn Ala Leu Val Glu Glu Tyr Glu Gly Thr Ser Ala Leu Lys
            100                 105                 110         
Glu Leu Ser Leu Gln Ala Ser Leu Ala Arg Pro Glu Ala Arg Thr Leu
        115                 120                 125             
Gln Lys Asp Met Ala Asp Leu Tyr Glu Tyr Lys Tyr Cys Thr Asp Val
    130                 135                 140                 
Asp Leu Ile Phe Gln Glu Thr Cys Phe Pro Val His Arg Ala Ile Leu
145                 150                 155                 160 
Ala Ala Arg Cys Pro Phe Phe Lys Thr Leu Leu Ser Ser Ser Pro Glu
                165                 170                 175     
Tyr Gly Ala Glu Ile Ile Met Asp Ile Asn Thr Ala Gly Ile Asp Met
            180                 185                 190         
Pro Met Phe Ser Ala Leu Leu His Tyr Leu Tyr Thr Gly Glu Phe Gly
        195                 200                 205             
Met Glu Asp Ser Arg Phe Gln Asn Val Asp Ile Leu Val Gln Leu Ser
    210                 215                 220                 
Glu Glu Phe Gly Thr Pro Asn Ser Leu Asp Val Asp Met Arg Gly Leu
225                 230                 235                 240 
Phe Asp Tyr Met Cys Tyr Tyr Asp Val Val Leu Ser Phe Ser Ser Asp
                245                 250                 255     
Ser Glu Leu Val Glu Ala Phe Gly Gly Asn Gln Asn Cys Leu Asp Glu
            260                 265                 270         
Glu Leu Lys Ala His Lys Ala Val Ile Ser Ala Arg Ser Pro Phe Phe
        275                 280                 285             
Arg Asn Leu Leu Gln Arg Arg Ile Arg Thr Gly Glu Glu Ile Thr Asp
    290                 295                 300                 
Arg Thr Leu Arg Thr Pro Thr Arg Ile Ile Leu Asp Glu Ser Ile Ile
305                 310                 315                 320 
Pro Lys Lys Tyr Ala Thr Val Ile Leu His Cys Met Tyr Thr Asp Val
                325                 330                 335     
Val Asp Leu Ser Val Leu His Cys Ser Pro Ser Val Gly Ser Leu Ser
            340                 345                 350         
Glu Val Gln Ala Leu Val Ala Gly Lys Pro Asn Met Thr Arg Ala Glu
        355                 360                 365             
Glu Ala Met Glu Leu Tyr His Ile Ala Leu Phe Leu Glu Phe Asn Met
    370                 375                 380                 
Leu Ala Gln Glu Glu Thr Thr Val Ile Arg Pro Ala Cys Ala Ala Glu
385                 390                 395                 400 
Leu Ser Asn Ser Cys Leu Leu Pro Gln Ser
                405                 410 


<210> 941
<211> 559
<212> PRT
<213> Homo sapiens

<400> 941
Met Ala Thr Ala Leu Ser Glu Glu Glu Leu Asp Asn Glu Asp Tyr Tyr
 1               5                  10                  15      
Ser Leu Leu Asn Val Arg Arg Glu Ala Ser Ser Glu Glu Leu Lys Ala
            20                  25                  30          
Ala Tyr Arg Arg Leu Cys Met Leu Tyr His Pro Asp Lys His Arg Asp
        35                  40                  45              
Pro Glu Leu Lys Ser Gln Ala Glu Arg Leu Phe Asn Leu Val His Gln
    50                  55                  60                  
Ala Tyr Glu Val Leu Ser Asp Pro Gln Thr Arg Ala Ile Tyr Asp Ile
65                  70                  75                  80  
Tyr Gly Lys Arg Gly Leu Glu Met Glu Gly Trp Glu Val Val Glu Arg
                85                  90                  95      
Arg Arg Thr Pro Ala Glu Ile Arg Glu Glu Phe Glu Arg Leu Gln Arg
            100                 105                 110         
Glu Arg Glu Glu Arg Arg Leu Gln Gln Arg Thr Asn Pro Lys Gly Thr
        115                 120                 125             
Ile Ser Val Gly Val Asp Ala Thr Asp Leu Phe Asp Arg Tyr Asp Glu
    130                 135                 140                 
Glu Tyr Glu Asp Val Ser Gly Ser Ser Phe Pro Gln Ile Glu Ile Asn
145                 150                 155                 160 
Lys Met His Ile Ser Gln Ser Ile Glu Ala Pro Leu Thr Ala Thr Asp
                165                 170                 175     
Thr Ala Ile Leu Ser Gly Ser Leu Ser Thr Gln Asn Gly Asn Gly Gly
            180                 185                 190         
Gly Ser Ile Asn Phe Ala Leu Arg Arg Val Thr Ser Ala Lys Gly Trp
        195                 200                 205             
Gly Glu Leu Glu Phe Gly Ala Gly Asp Leu Gln Gly Pro Leu Phe Gly
    210                 215                 220                 
Leu Lys Leu Phe Arg Asn Leu Thr Pro Arg Cys Phe Val Thr Thr Asn
225                 230                 235                 240 
Cys Ala Leu Gln Phe Ser Ser Arg Gly Ile Arg Pro Gly Leu Thr Thr
                245                 250                 255     
Val Leu Ala Arg Asn Leu Asp Lys Asn Thr Met Gly Tyr Leu Gln Trp
            260                 265                 270         
Arg Trp Gly Ile Gln Ser Ala Met Asn Thr Ser Ile Val Arg Asp Thr
        275                 280                 285             
Lys Thr Ser His Phe Thr Val Ala Leu Gln Leu Gly Ile Pro His Ser
    290                 295                 300                 
Phe Ala Leu Ile Ile Tyr Gln His Lys Phe Gln Asp Asp Asp Gln Thr
305                 310                 315                 320 
Arg Val Lys Gly Ser Leu Lys Ala Gly Phe Phe Gly Thr Val Val Glu
                325                 330                 335     
Tyr Gly Ala Glu Arg Lys Ile Ser Arg His Ser Val Leu Gly Ala Ala
            340                 345                 350         
Val Ser Val Gly Val Pro Gln Gly Val Ser Leu Lys Val Lys Leu Asn
        355                 360                 365             
Arg Ala Ser Gln Thr Tyr Phe Phe Pro Ile His Leu Thr Asp Gln Leu
    370                 375                 380                 
Leu Pro Ser Ala Met Phe Tyr Ala Thr Val Gly Pro Leu Val Val Tyr
385                 390                 395                 400 
Phe Ala Met His Arg Leu Ile Ile Lys Pro Tyr Leu Arg Ala Gln Lys
                405                 410                 415     
Glu Lys Glu Leu Glu Lys Gln Arg Glu Ser Ala Ala Thr Asp Val Leu
            420                 425                 430         
Gln Lys Lys Gln Glu Ala Glu Ser Ala Val Arg Leu Met Gln Glu Ser
        435                 440                 445             
Val Arg Arg Ile Ile Glu Ala Glu Glu Ser Arg Met Gly Leu Ile Ile
    450                 455                 460                 
Val Asn Ala Trp Tyr Gly Lys Phe Val Asn Asp Lys Ser Arg Lys Ser
465                 470                 475                 480 
Glu Lys Val Lys Val Ile Asp Val Thr Val Pro Leu Gln Cys Leu Val
                485                 490                 495     
Lys Asp Ser Lys Leu Ile Leu Thr Glu Ala Ser Lys Ala Gly Leu Pro
            500                 505                 510         
Gly Phe Tyr Asp Pro Cys Val Gly Glu Glu Lys Asn Leu Lys Val Leu
        515                 520                 525             
Tyr Gln Phe Arg Gly Val Leu His Gln Val Met Val Leu Asp Ser Glu
    530                 535                 540                 
Ala Leu Arg Ile Pro Lys Gln Ser His Arg Ile Asp Thr Asp Gly
545                 550                 555                 


<210> 942
<211> 773
<212> PRT
<213> Homo sapiens

<400> 942
Met Ala Glu Cys Gly Ala Ser Gly Ser Gly Ser Ser Gly Asp Ser Leu
 1               5                  10                  15      
Asp Lys Ser Ile Thr Leu Pro Pro Asp Glu Ile Phe Arg Asn Leu Glu
            20                  25                  30          
Asn Ala Lys Arg Phe Ala Ile Asp Ile Gly Gly Ser Leu Thr Lys Leu
        35                  40                  45              
Ala Tyr Tyr Ser Thr Val Gln His Lys Val Ala Lys Val Arg Ser Phe
    50                  55                  60                  
Asp His Ser Gly Lys Asp Thr Glu Arg Glu His Glu Pro Pro Tyr Glu
65                  70                  75                  80  
Ile Ser Val Gln Glu Glu Ile Thr Ala Arg Leu His Phe Ile Lys Phe
                85                  90                  95      
Glu Asn Thr Tyr Ile Glu Ala Cys Leu Asp Phe Ile Lys Asp His Leu
            100                 105                 110         
Val Asn Thr Glu Thr Lys Val Ile Gln Ala Thr Gly Gly Gly Ala Tyr
        115                 120                 125             
Lys Phe Lys Asp Leu Ile Glu Glu Lys Leu Arg Leu Lys Val Asp Lys
    130                 135                 140                 
Glu Asp Val Met Thr Cys Leu Ile Lys Gly Cys Asn Phe Val Leu Lys
145                 150                 155                 160 
Asn Ile Pro His Glu Ala Phe Val Tyr Gln Lys Asp Ser Asp Pro Glu
                165                 170                 175     
Phe Arg Phe Gln Thr Asn His Pro His Ile Phe Pro Tyr Leu Leu Val
            180                 185                 190         
Asn Ile Gly Ser Gly Val Ser Ile Val Lys Val Glu Thr Glu Asp Arg
        195                 200                 205             
Phe Glu Trp Val Gly Gly Ser Ser Ile Gly Gly Gly Thr Phe Trp Gly
    210                 215                 220                 
Leu Gly Ala Leu Leu Thr Lys Thr Lys Lys Phe Asp Glu Leu Leu His
225                 230                 235                 240 
Leu Ala Ser Arg Gly Gln His Ser Asn Val Asp Met Leu Val Arg Asp
                245                 250                 255     
Val Tyr Gly Gly Ala His Gln Thr Leu Gly Leu Ser Gly Asn Leu Ile
            260                 265                 270         
Ala Ser Ser Phe Gly Lys Ser Ala Thr Ala Asp Gln Glu Phe Ser Lys
        275                 280                 285             
Glu Asp Met Ala Lys Ser Leu Leu His Met Ile Ser Asn Asp Ile Gly
    290                 295                 300                 
Gln Leu Ala Cys Leu His Ala Arg Leu His Ser Leu Asp Arg Val Tyr
305                 310                 315                 320 
Phe Gly Gly Phe Phe Ile Arg Gly His Pro Val Thr Met Arg Thr Ile
                325                 330                 335     
Thr Tyr Ser Ile Asn Phe Phe Ser Lys Gly Glu Val Gln Ala Leu Phe
            340                 345                 350         
Leu Arg His Glu Gly Tyr Leu Gly Ala Ile Gly Ala Phe Leu Lys Gly
        355                 360                 365             
Ala Glu Gln Asp Asn Pro Asn Gln Tyr Ser Trp Gly Glu Asn Tyr Ala
    370                 375                 380                 
Gly Ser Ser Gly Leu Met Ser Ala Ser Pro Glu Leu Gly Pro Ala Gln
385                 390                 395                 400 
Arg Ala Arg Ser Gly Thr Phe Asp Leu Leu Glu Met Asp Arg Leu Glu
                405                 410                 415     
Arg Pro Leu Val Asp Leu Pro Leu Leu Leu Asp Pro Pro Ser Tyr Val
            420                 425                 430         
Pro Asp Thr Val Asp Leu Thr Asp Asp Ala Leu Ala Arg Lys Tyr Trp
        435                 440                 445             
Leu Thr Cys Phe Glu Glu Ala Leu Asp Gly Val Val Lys Arg Ala Val
    450                 455                 460                 
Ala Ser Gln Pro Asp Ser Val Asp Ala Ala Glu Arg Ala Glu Lys Phe
465                 470                 475                 480 
Arg Gln Lys Tyr Trp Asn Lys Leu Gln Thr Leu Arg Gln Gln Pro Phe
                485                 490                 495     
Ala Tyr Gly Thr Leu Thr Val Arg Ser Leu Leu Asp Thr Arg Glu His
            500                 505                 510         
Cys Leu Asn Glu Phe Asn Phe Pro Asp Pro Tyr Ser Lys Val Lys Gln
        515                 520                 525             
Arg Glu Asn Gly Val Ala Leu Arg Cys Phe Pro Gly Val Val Arg Ser
    530                 535                 540                 
Leu Asp Ala Leu Gly Trp Glu Glu Arg Gln Leu Ala Leu Val Lys Gly
545                 550                 555                 560 
Leu Leu Ala Gly Asn Val Phe Asp Trp Gly Ala Lys Ala Val Ser Ala
                565                 570                 575     
Val Leu Glu Ser Asp Pro Tyr Phe Gly Phe Glu Glu Ala Lys Arg Lys
            580                 585                 590         
Leu Gln Glu Arg Pro Trp Leu Val Asp Ser Tyr Ser Glu Trp Leu Gln
        595                 600                 605             
Arg Leu Lys Gly Pro Pro His Lys Cys Ala Leu Ile Phe Ala Asp Asn
    610                 615                 620                 
Ser Gly Ile Asp Ile Ile Leu Gly Val Phe Pro Phe Val Arg Glu Leu
625                 630                 635                 640 
Leu Leu Arg Gly Thr Glu Val Ile Leu Ala Cys Asn Ser Gly Pro Ala
                645                 650                 655     
Leu Asn Asp Val Thr His Ser Glu Ser Leu Ile Val Ala Glu Arg Ile
            660                 665                 670         
Ala Gly Met Asp Pro Val Val His Ser Ala Leu Gln Glu Glu Arg Leu
        675                 680                 685             
Leu Leu Val Gln Thr Gly Ser Ser Ser Pro Cys Leu Asp Leu Ser Arg
    690                 695                 700                 
Leu Asp Lys Gly Leu Ala Ala Leu Val Arg Glu Arg Gly Ala Asp Leu
705                 710                 715                 720 
Val Val Ile Glu Gly Met Gly Arg Ala Val His Thr Asn Tyr His Ala
                725                 730                 735     
Ala Leu Arg Cys Glu Ser Leu Lys Leu Ala Val Ile Lys Asn Ala Trp
            740                 745                 750         
Leu Ala Glu Arg Leu Gly Gly Arg Leu Phe Ser Val Ile Phe Lys Tyr
        755                 760                 765             
Glu Val Pro Ala Glu
    770             


<210> 943
<211> 422
<212> PRT
<213> Homo sapiens

<400> 943
Met Thr Val Phe Phe Lys Thr Leu Arg Asn His Trp Lys Lys Thr Thr
 1               5                  10                  15      
Ala Gly Leu Cys Leu Leu Thr Trp Gly Gly His Trp Leu Tyr Gly Lys
            20                  25                  30          
His Cys Asp Asn Leu Leu Arg Arg Ala Ala Cys Gln Glu Ala Gln Val
        35                  40                  45              
Phe Gly Asn Gln Leu Ile Pro Pro Asn Ala Gln Val Lys Lys Ala Thr
    50                  55                  60                  
Val Phe Leu Asn Pro Ala Ala Cys Lys Gly Lys Ala Arg Thr Leu Phe
65                  70                  75                  80  
Glu Lys Asn Ala Ala Pro Ile Leu His Leu Ser Gly Met Asp Val Thr
                85                  90                  95      
Ile Val Lys Thr Asp Tyr Glu Gly Gln Ala Lys Lys Leu Leu Glu Leu
            100                 105                 110         
Met Glu Asn Thr Asp Val Ile Ile Val Ala Gly Gly Asp Gly Thr Leu
        115                 120                 125             
Gln Glu Val Val Thr Gly Val Leu Arg Arg Thr Asp Glu Ala Thr Phe
    130                 135                 140                 
Ser Lys Ile Pro Ile Gly Phe Ile Pro Leu Gly Glu Thr Ser Ser Leu
145                 150                 155                 160 
Ser His Thr Leu Phe Ala Glu Ser Gly Asn Lys Val Gln His Ile Thr
                165                 170                 175     
Asp Ala Thr Leu Ala Ile Val Lys Gly Glu Thr Val Pro Leu Asp Val
            180                 185                 190         
Leu Gln Ile Lys Gly Glu Lys Glu Gln Pro Val Phe Ala Met Thr Gly
        195                 200                 205             
Leu Arg Trp Gly Ser Phe Arg Asp Ala Gly Val Lys Val Ser Lys Tyr
    210                 215                 220                 
Trp Tyr Leu Gly Pro Leu Lys Ile Lys Ala Ala His Phe Phe Ser Thr
225                 230                 235                 240 
Leu Lys Glu Trp Pro Gln Thr His Gln Ala Ser Ile Ser Tyr Thr Gly
                245                 250                 255     
Pro Thr Glu Arg Pro Pro Asn Glu Pro Glu Glu Thr Pro Val Gln Arg
            260                 265                 270         
Pro Ser Leu Tyr Arg Arg Ile Leu Arg Arg Leu Ala Ser Tyr Trp Ala
        275                 280                 285             
Gln Pro Gln Asp Ala Leu Ser Gln Glu Val Ser Pro Glu Val Trp Lys
    290                 295                 300                 
Asp Val Gln Leu Ser Thr Ile Glu Leu Ser Ile Thr Thr Arg Asn Asn
305                 310                 315                 320 
Gln Leu Asp Pro Thr Ser Lys Glu Asp Phe Leu Asn Ile Cys Ile Glu
                325                 330                 335     
Pro Asp Thr Ile Ser Lys Gly Asp Phe Ile Thr Ile Gly Ser Arg Lys
            340                 345                 350         
Val Arg Asn Pro Lys Leu His Val Glu Gly Thr Glu Cys Leu Gln Ala
        355                 360                 365             
Ser Gln Cys Thr Leu Leu Ile Pro Glu Gly Ala Gly Gly Ser Phe Ser
    370                 375                 380                 
Ile Asp Ser Glu Glu Tyr Glu Ala Met Pro Val Glu Val Lys Leu Leu
385                 390                 395                 400 
Pro Arg Lys Leu Gln Phe Phe Cys Asp Pro Arg Lys Arg Glu Gln Met
                405                 410                 415     
Leu Thr Ser Pro Thr Gln
            420         


<210> 944
<211> 956
<212> PRT
<213> Homo sapiens

<400> 944
Met Ala Ala Ala Val Gly Val Arg Gly Arg Tyr Glu Leu Pro Pro Cys
 1               5                  10                  15      
Ser Gly Pro Gly Trp Leu Leu Ser Leu Ser Ala Leu Leu Ser Val Ala
            20                  25                  30          
Ala Arg Gly Ala Phe Ala Thr Thr His Trp Val Val Thr Glu Asp Gly
        35                  40                  45              
Lys Ile Gln Gln Gln Val Asp Ser Pro Met Asn Leu Lys His Pro His
    50                  55                  60                  
Asp Leu Val Ile Leu Met Arg Gln Glu Ala Thr Val Asn Tyr Leu Lys
65                  70                  75                  80  
Glu Leu Glu Lys Gln Leu Val Ala Gln Lys Ile His Ile Glu Glu Asn
                85                  90                  95      
Glu Asp Arg Asp Thr Gly Leu Glu Gln Arg His Asn Lys Glu Asp Pro
            100                 105                 110         
Asp Cys Ile Lys Ala Lys Val Pro Leu Gly Asp Leu Asp Leu Tyr Asp
        115                 120                 125             
Gly Thr Tyr Ile Thr Leu Glu Ser Lys Asp Ile Ser Pro Glu Asp Tyr
    130                 135                 140                 
Ile Asp Thr Glu Ser Pro Val Pro Pro Asp Pro Glu Gln Pro Asp Cys
145                 150                 155                 160 
Thr Lys Ile Leu Glu Leu Pro Cys Ser Ile His Ala Phe Gln His Leu
                165                 170                 175     
Arg Gly Val Gln Glu Arg Val Asn Leu Ser Ala Pro Leu Leu Pro Lys
            180                 185                 190         
Glu Asp Pro Ile Phe Thr Tyr Leu Ser Lys Arg Leu Gly Arg Ser Ile
        195                 200                 205             
Asp Asp Ile Gly His Leu Ile His Glu Gly Leu Gln Lys Asn Thr Ser
    210                 215                 220                 
Ser Trp Val Leu Tyr Asn Met Ala Ser Phe Tyr Trp Arg Ile Lys Asn
225                 230                 235                 240 
Glu Pro Tyr Gln Val Val Glu Cys Ala Met Arg Ala Leu His Phe Ser
                245                 250                 255     
Ser Arg His Asn Lys Asp Ile Ala Leu Val Asn Leu Ala Asn Val Leu
            260                 265                 270         
His Arg Ala His Phe Ser Ala Asp Ala Ala Val Val Val His Ala Ala
        275                 280                 285             
Leu Asp Asp Ser Asp Phe Phe Thr Ser Tyr Tyr Thr Leu Gly Asn Ile
    290                 295                 300                 
Tyr Ala Met Leu Gly Glu Tyr Asn His Ser Val Leu Cys Tyr Asp His
305                 310                 315                 320 
Ala Leu Gln Ala Arg Pro Gly Phe Glu Gln Ala Ile Lys Arg Lys His
                325                 330                 335     
Ala Val Leu Cys Gln Gln Lys Leu Glu Gln Lys Leu Glu Ala Gln His
            340                 345                 350         
Arg Ser Leu Gln Arg Thr Leu Asn Glu Leu Lys Glu Tyr Gln Lys Gln
        355                 360                 365             
His Asp His Tyr Leu Arg Gln Gln Glu Ile Leu Glu Lys His Lys Leu
    370                 375                 380                 
Ile Gln Glu Glu Gln Ile Leu Arg Asn Ile Ile His Glu Thr Gln Met
385                 390                 395                 400 
Ala Lys Glu Ala Gln Leu Gly Asn His Gln Ile Cys Arg Leu Val Asn
                405                 410                 415     
Gln Gln His Ser Leu His Cys Arg Trp Asp Gln Pro Val Arg Tyr His
            420                 425                 430         
Arg Gly Asp Ile Phe Glu Asn Val Asp Tyr Val Gln Phe Gly Glu Asp
        435                 440                 445             
Ser Ser Thr Ser Ser Met Met Ser Val Asn Phe Asp Val Gln Ser Asn
    450                 455                 460                 
Gln Ser Asp Ile Asn Asp Ser Val Lys Ser Ser Pro Val Ala His Ser
465                 470                 475                 480 
Ile Leu Trp Ile Trp Gly Arg Asp Ser Asp Ala Tyr Arg Asp Lys Gln
                485                 490                 495     
His Ile Leu Trp Pro Lys Arg Ala Asp Cys Thr Glu Ser Tyr Pro Arg
            500                 505                 510         
Val Pro Val Gly Gly Glu Leu Pro Thr Tyr Phe Leu Pro Pro Glu Asn
        515                 520                 525             
Lys Gly Leu Arg Ile His Glu Leu Ser Ser Asp Asp Tyr Ser Thr Glu
    530                 535                 540                 
Glu Glu Ala Gln Thr Pro Asp Cys Ser Ile Thr Asp Phe Arg Lys Ser
545                 550                 555                 560 
His Thr Leu Ser Tyr Leu Val Lys Glu Leu Glu Val Arg Met Asp Leu
                565                 570                 575     
Lys Ala Lys Met Pro Asp Asp His Ala Arg Lys Ile Leu Leu Ser Arg
            580                 585                 590         
Ile Asn Asn Tyr Thr Ile Pro Glu Glu Glu Ile Gly Ser Phe Leu Phe
        595                 600                 605             
His Ala Ile Asn Lys Pro Asn Ala Pro Ile Trp Leu Ile Leu Asn Glu
    610                 615                 620                 
Ala Gly Leu Tyr Trp Arg Ala Val Gly Asn Ser Thr Phe Ala Ile Ala
625                 630                 635                 640 
Cys Leu Gln Arg Ala Leu Asn Leu Ala Pro Leu Gln Tyr Gln Asp Val
                645                 650                 655     
Pro Leu Val Asn Leu Ala Asn Leu Leu Ile His Tyr Gly Leu His Leu
            660                 665                 670         
Asp Ala Thr Lys Leu Leu Leu Gln Ala Leu Ala Ile Asn Ser Ser Glu
        675                 680                 685             
Pro Leu Thr Phe Leu Ser Leu Gly Asn Ala Tyr Leu Ala Leu Lys Asn
    690                 695                 700                 
Ile Ser Gly Ala Leu Glu Ala Phe Arg Gln Ala Leu Lys Leu Thr Thr
705                 710                 715                 720 
Lys Cys Pro Glu Cys Glu Asn Ser Leu Lys Leu Ile Arg Cys Met Gln
                725                 730                 735     
Phe Tyr Pro Phe Leu Tyr Asn Ile Thr Ser Ser Val Cys Ser Gly Asn
            740                 745                 750         
Cys His Glu Lys Thr Leu Asp Asn Ser Arg Asp Lys Gln Lys Tyr Phe
        755                 760                 765             
Asp Asn Ser Gln Ser Leu Asp Ala Ala Glu Glu Glu Pro Ser Glu Arg
    770                 775                 780                 
Gly Thr Glu Glu Asp Pro Val Phe Ser Val Glu Asn Ser Gly Arg Asp
785                 790                 795                 800 
Ser Asp Ala Leu Arg Leu Glu Ser Thr Val Val Glu Glu Ser Asn Gly
                805                 810                 815     
Ser Asp Glu Met Glu Asn Ser Asp Glu Thr Lys Met Ser Glu Glu Ile
            820                 825                 830         
Leu Ala Leu Val Asp Glu Phe Gln Gln Ala Trp Pro Leu Glu Gly Phe
        835                 840                 845             
Gly Gly Ala Leu Glu Met Lys Gly Arg Arg Leu Asp Leu Gln Gly Ile
    850                 855                 860                 
Arg Val Leu Lys Lys Gly Pro Gln Asp Gly Val Ala Arg Ser Ser Cys
865                 870                 875                 880 
Tyr Gly Asp Cys Arg Ser Glu Asp Asp Glu Ala Thr Glu Trp Ile Thr
                885                 890                 895     
Phe Gln Val Lys Arg Val Lys Lys Pro Lys Gly Asp His Lys Lys Thr
            900                 905                 910         
Pro Gly Lys Lys Val Glu Thr Gly Gln Ile Glu Asn Gly His Arg Tyr
        915                 920                 925             
Gln Ala Asn Leu Glu Ile Thr Gly Pro Lys Val Ala Ser Pro Gly Pro
    930                 935                 940                 
Gln Gly Leu Leu Asp Trp Lys Thr Arg Lys Val Pro
945                 950                 955     


<210> 945
<211> 261
<212> PRT
<213> Homo sapiens

<400> 945
Met Leu Arg Val Leu Cys Leu Leu Arg Pro Trp Arg Pro Leu Arg Ala
 1               5                  10                  15      
Arg Gly Cys Ala Ser Asp Gly Ala Ala Gly Gly Ser Glu Ile Gln Val
            20                  25                  30          
Arg Ala Leu Ala Gly Pro Asp Gln Gly Ile Thr Glu Ile Leu Met Asn
        35                  40                  45              
Arg Pro Ser Ala Arg Asn Ala Leu Gly Asn Val Phe Val Ser Glu Leu
    50                  55                  60                  
Leu Glu Thr Leu Ala Gln Leu Arg Glu Asp Arg Gln Val Arg Val Leu
65                  70                  75                  80  
Leu Phe Arg Ser Gly Val Lys Gly Ala Phe Cys Ala Gly Ala Asp Leu
                85                  90                  95      
Lys Glu Arg Glu Gln Met Ser Glu Ala Glu Val Gly Val Phe Val Gln
            100                 105                 110         
Arg Leu Arg Gly Leu Met Asn Asp Ile Ala Ser Ser Ala Val Met Gly
        115                 120                 125             
Leu Ile Glu Thr Thr Arg Gly Leu Leu Pro Gly Ala Gly Gly Thr Gln
    130                 135                 140                 
Arg Leu Pro Arg Cys Leu Gly Val Ala Leu Ala Lys Glu Leu Ile Phe
145                 150                 155                 160 
Thr Gly Arg Arg Leu Ser Gly Thr Glu Ala His Val Leu Gly Leu Val
                165                 170                 175     
Asn His Ala Val Ala Gln Asn Glu Glu Gly Asp Ala Ala Tyr Gln Arg
            180                 185                 190         
Ala Arg Ala Leu Ala Gln Glu Ile Leu Pro Gln Ala Pro Ile Ala Val
        195                 200                 205             
Arg Leu Gly Lys Val Ala Ile Asn Arg Gly Thr Glu Val Asp Ile Ala
    210                 215                 220                 
Ser Gly Met Ala Ile Glu Gly Met Cys Tyr Ala Gln Asn Ile Pro Thr
225                 230                 235                 240 
Arg Asp Arg Leu Glu Gly Met Ala Ala Phe Arg Glu Lys Arg Thr Pro
                245                 250                 255     
Lys Phe Val Gly Lys
            260     


<210> 946
<211> 612
<212> PRT
<213> Homo sapiens

<400> 946
Met Ala Ala Pro Glu Gly Ser Gly Leu Gly Glu Asp Ala Arg Leu Asp
 1               5                  10                  15      
Gln Glu Thr Ala Gln Trp Leu Arg Trp Asp Lys Asn Ser Leu Thr Leu
            20                  25                  30          
Glu Ala Val Lys Arg Leu Ile Ala Glu Gly Asn Lys Glu Glu Leu Arg
        35                  40                  45              
Lys Cys Phe Gly Ala Arg Met Glu Phe Gly Thr Ala Gly Leu Arg Ala
    50                  55                  60                  
Ala Met Gly Pro Gly Ile Ser Arg Met Asn Asp Leu Thr Ile Ile Gln
65                  70                  75                  80  
Thr Thr Gln Gly Phe Cys Arg Tyr Leu Glu Lys Gln Phe Ser Asp Leu
                85                  90                  95      
Lys Gln Lys Gly Ile Val Ile Ser Phe Asp Ala Arg Ala His Pro Ser
            100                 105                 110         
Ser Gly Gly Ser Ser Arg Arg Phe Ala Arg Leu Ala Ala Thr Thr Phe
        115                 120                 125             
Ile Ser Gln Gly Ile Pro Val Tyr Leu Phe Ser Asp Ile Thr Pro Thr
    130                 135                 140                 
Pro Phe Val Pro Phe Thr Val Ser His Leu Lys Leu Cys Ala Gly Ile
145                 150                 155                 160 
Met Val Thr Ala Ser His Asn Pro Lys Gln Asp Asn Gly Tyr Lys Val
                165                 170                 175     
Tyr Trp Asp Asn Gly Ala Gln Ile Ile Ser Pro His Asp Lys Gly Ile
            180                 185                 190         
Ser Gln Ala Ile Glu Glu Asn Leu Glu Pro Trp Pro Gln Ala Trp Asp
        195                 200                 205             
Asp Ser Leu Ile Asp Ser Ser Pro Leu Leu His Asn Pro Ser Ala Ser
    210                 215                 220                 
Ile Asn Asn Asp Tyr Phe Glu Asp Leu Lys Lys Tyr Cys Phe His Arg
225                 230                 235                 240 
Ser Val Asn Arg Glu Thr Lys Val Lys Phe Val His Thr Ser Val His
                245                 250                 255     
Gly Val Gly His Ser Phe Val Gln Ser Ala Phe Lys Ala Phe Asp Leu
            260                 265                 270         
Val Pro Pro Glu Ala Val Pro Glu Gln Lys Asp Pro Asp Pro Glu Phe
        275                 280                 285             
Pro Thr Val Lys Tyr Pro Asn Pro Glu Glu Gly Lys Gly Val Leu Thr
    290                 295                 300                 
Leu Ser Phe Ala Leu Ala Asp Lys Thr Lys Ala Arg Ile Val Leu Ala
305                 310                 315                 320 
Asn Asp Pro Asp Ala Asp Arg Leu Ala Val Ala Glu Lys Gln Asp Ser
                325                 330                 335     
Gly Glu Trp Arg Val Phe Ser Gly Asn Glu Leu Gly Ala Leu Leu Gly
            340                 345                 350         
Trp Trp Leu Phe Thr Ser Trp Lys Glu Lys Asn Gln Asp Arg Ser Ala
        355                 360                 365             
Leu Lys Asp Thr Tyr Met Leu Ser Ser Thr Val Ser Ser Lys Ile Leu
    370                 375                 380                 
Arg Ala Ile Ala Leu Lys Glu Gly Phe His Phe Glu Glu Thr Leu Thr
385                 390                 395                 400 
Gly Phe Lys Trp Met Gly Asn Arg Ala Lys Gln Leu Ile Asp Gln Gly
                405                 410                 415     
Lys Thr Val Leu Phe Ala Phe Glu Glu Ala Ile Gly Tyr Met Cys Cys
            420                 425                 430         
Pro Phe Val Leu Asp Lys Asp Gly Val Ser Ala Ala Val Ile Ser Ala
        435                 440                 445             
Glu Leu Ala Ser Phe Leu Ala Thr Lys Asn Leu Ser Leu Ser Gln Gln
    450                 455                 460                 
Leu Lys Ala Ile Tyr Val Glu Tyr Gly Tyr His Ile Thr Lys Ala Ser
465                 470                 475                 480 
Tyr Phe Ile Cys His Asp Gln Glu Thr Ile Lys Lys Leu Phe Glu Asn
                485                 490                 495     
Leu Arg Asn Tyr Asp Gly Lys Asn Asn Tyr Pro Lys Ala Cys Gly Lys
            500                 505                 510         
Phe Glu Ile Ser Ala Ile Arg Asp Leu Thr Thr Gly Tyr Asp Asp Ser
        515                 520                 525             
Gln Pro Asp Lys Lys Ala Val Leu Pro Thr Ser Lys Ser Ser Gln Met
    530                 535                 540                 
Ile Thr Phe Thr Phe Ala Asn Gly Gly Val Ala Thr Met Arg Thr Ser
545                 550                 555                 560 
Gly Thr Glu Pro Lys Ile Lys Tyr Tyr Ala Glu Leu Cys Ala Pro Pro
                565                 570                 575     
Gly Asn Ser Asp Pro Glu Gln Leu Lys Lys Glu Leu Asn Glu Leu Val
            580                 585                 590         
Ser Ala Ile Glu Glu His Phe Phe Gln Pro Gln Lys Tyr Asn Leu Gln
        595                 600                 605             
Pro Lys Ala Asp
    610         


<210> 947
<211> 484
<212> PRT
<213> Homo sapiens

<400> 947
Met Asn Gln Tyr Thr Glu Ile Glu Thr Cys Val Glu Cys Ser Ala Lys
 1               5                  10                  15      
Asn Leu Lys Asn Ile Ser Glu Leu Phe Tyr Tyr Ala Gln Lys Ala Val
            20                  25                  30          
Leu His Pro Thr Gly Pro Leu Tyr Cys Pro Glu Glu Lys Glu Met Lys
        35                  40                  45              
Pro Ala Cys Ile Lys Ala Leu Thr Arg Ile Phe Lys Ile Ser Asp Gln
    50                  55                  60                  
Asp Asn Asp Gly Thr Leu Asn Asp Ala Glu Leu Asn Phe Phe Gln Arg
65                  70                  75                  80  
Ile Cys Phe Asn Thr Pro Leu Ala Pro Gln Ala Leu Glu Asp Val Lys
                85                  90                  95      
Asn Val Val Arg Lys His Ile Ser Asp Gly Val Ala Asp Ser Gly Leu
            100                 105                 110         
Thr Leu Lys Gly Phe Leu Phe Leu His Thr Leu Phe Ile Gln Arg Gly
        115                 120                 125             
Arg His Glu Thr Thr Trp Thr Val Leu Arg Arg Phe Gly Tyr Asp Asp
    130                 135                 140                 
Asp Leu Asp Leu Thr Pro Glu Tyr Leu Phe Pro Leu Leu Lys Ile Pro
145                 150                 155                 160 
Pro Asp Cys Thr Thr Glu Leu Asn His His Ala Tyr Leu Phe Leu Gln
                165                 170                 175     
Ser Thr Phe Asp Lys His Asp Leu Asp Arg Asp Cys Ala Leu Ser Pro
            180                 185                 190         
Asp Glu Leu Lys Asp Leu Phe Lys Val Phe Pro Tyr Ile Pro Trp Gly
        195                 200                 205             
Pro Asp Val Asn Asn Thr Val Cys Thr Asn Glu Arg Gly Trp Ile Thr
    210                 215                 220                 
Tyr Gln Gly Phe Leu Ser Gln Trp Thr Leu Thr Thr Tyr Leu Asp Val
225                 230                 235                 240 
Gln Arg Cys Leu Glu Tyr Leu Gly Tyr Leu Gly Tyr Ser Ile Leu Thr
                245                 250                 255     
Glu Gln Glu Ser Gln Ala Ser Ala Val Thr Val Thr Arg Asp Lys Lys
            260                 265                 270         
Ile Asp Leu Gln Lys Lys Gln Thr Gln Arg Asn Val Phe Arg Cys Asn
        275                 280                 285             
Val Ile Gly Val Lys Asn Cys Gly Lys Ser Gly Val Leu Gln Ala Leu
    290                 295                 300                 
Leu Gly Arg Asn Leu Met Arg Gln Lys Lys Ile Arg Glu Asp His Lys
305                 310                 315                 320 
Ser Tyr Tyr Ala Ile Asn Thr Val Tyr Val Tyr Gly Gln Glu Lys Tyr
                325                 330                 335     
Leu Leu Leu His Asp Ile Ser Glu Ser Glu Phe Leu Thr Glu Ala Glu
            340                 345                 350         
Ile Ile Cys Asp Val Val Cys Leu Val Tyr Asp Val Ser Asn Pro Lys
        355                 360                 365             
Ser Phe Glu Tyr Cys Ala Arg Ile Phe Lys Gln His Phe Met Asp Ser
    370                 375                 380                 
Arg Ile Pro Cys Leu Ile Val Ala Ala Lys Ser Asp Leu His Glu Val
385                 390                 395                 400 
Lys Gln Glu Tyr Ser Ile Ser Pro Thr Asp Phe Cys Arg Lys His Lys
                405                 410                 415     
Met Pro Pro Pro Gln Ala Phe Thr Cys Asn Thr Ala Asp Ala Pro Ser
            420                 425                 430         
Lys Asp Ile Phe Val Lys Leu Thr Thr Met Ala Met Tyr Pro His Val
        435                 440                 445             
Thr Gln Ala Asp Pro Lys Ser Ser Thr Phe Trp Leu Arg Ala Ser Phe
    450                 455                 460                 
Gly Ala Thr Val Phe Ala Val Leu Gly Phe Ala Met Tyr Lys Ala Leu
465                 470                 475                 480 
Leu Lys Gln Arg
                


<210> 948
<211> 306
<212> PRT
<213> Homo sapiens

<400> 948
Met Ala Val Ala Arg Leu Ala Ala Val Ala Ala Trp Val Pro Cys Arg
 1               5                  10                  15      
Ser Trp Gly Trp Ala Ala Val Pro Phe Gly Pro His Arg Gly Leu Ser
            20                  25                  30          
Val Leu Leu Ala Arg Ile Pro Gln Arg Ala Pro Arg Trp Leu Pro Ala
        35                  40                  45              
Cys Arg Gln Lys Thr Ser Leu Ser Phe Leu Asn Arg Pro Asp Leu Pro
    50                  55                  60                  
Asn Leu Ala Tyr Lys Lys Leu Lys Gly Lys Ser Pro Gly Ile Ile Phe
65                  70                  75                  80  
Ile Pro Gly Tyr Leu Ser Tyr Met Asn Gly Thr Lys Ala Leu Ala Ile
                85                  90                  95      
Glu Glu Phe Cys Lys Ser Leu Gly His Ala Cys Ile Arg Phe Asp Tyr
            100                 105                 110         
Ser Gly Val Gly Ser Ser Asp Gly Asn Ser Glu Glu Ser Thr Leu Gly
        115                 120                 125             
Lys Trp Arg Lys Asp Val Leu Ser Ile Ile Asp Asp Leu Ala Asp Gly
    130                 135                 140                 
Pro Gln Ile Leu Val Gly Ser Ser Leu Gly Gly Trp Leu Met Leu His
145                 150                 155                 160 
Ala Ala Ile Ala Arg Pro Glu Lys Val Val Ala Leu Ile Gly Val Ala
                165                 170                 175     
Thr Ala Ala Asp Thr Leu Val Thr Lys Phe Asn Gln Leu Pro Val Glu
            180                 185                 190         
Leu Lys Lys Glu Val Glu Met Lys Gly Val Trp Ser Met Pro Ser Lys
        195                 200                 205             
Tyr Ser Glu Glu Gly Val Tyr Asn Val Gln Tyr Ser Phe Ile Lys Glu
    210                 215                 220                 
Ala Glu His His Cys Leu Leu His Ser Pro Ile Pro Val Asn Cys Pro
225                 230                 235                 240 
Ile Arg Leu Leu His Gly Met Lys Asp Asp Ile Val Pro Trp His Thr
                245                 250                 255     
Ser Met Gln Val Ala Asp Arg Val Leu Ser Thr Asp Val Asp Val Ile
            260                 265                 270         
Leu Arg Lys His Ser Asp His Arg Met Arg Glu Lys Ala Asp Ile Gln
        275                 280                 285             
Leu Leu Val Tyr Thr Ile Asp Asp Leu Ile Asp Lys Leu Ser Thr Ile
    290                 295                 300                 
Val Asn
305     


<210> 949
<211> 423
<212> PRT
<213> Homo sapiens

<400> 949
Met Asp Arg Gly Gln Pro Ser Leu Glu Pro Ala Ala Ala Ala Pro Arg
 1               5                  10                  15      
Ala Ser Gly Arg Cys Val Ile Ala Pro Val Arg Ala Val Leu Arg Leu
            20                  25                  30          
Arg Arg Arg Val Cys Val Leu Arg Lys Arg Arg Leu Leu Gln Pro Gly
        35                  40                  45              
Gly Gly Pro Asp Val Gly Thr Gly Ala Pro Arg Pro Gly Cys Ser Pro
    50                  55                  60                  
Arg Ala Pro Arg Ala Asp Leu Asp Gln Pro Lys Phe Phe Thr Phe Asp
65                  70                  75                  80  
Ser Pro Ala Glu Leu Pro Ser Arg Thr Pro Arg Lys Lys Arg Arg Arg
                85                  90                  95      
Ser Arg Leu Val Leu Tyr Pro Glu Thr Ser Arg Lys Tyr Arg Pro Arg
            100                 105                 110         
Val Glu His Arg Ser Arg Ala Gln Arg Cys Leu Leu Leu Leu Val Ala
        115                 120                 125             
Ile Val Gly Phe Gln Val Leu Asn Ala Ile Glu Asn Leu Asp Asp Asn
    130                 135                 140                 
Ala Gln Arg Tyr Asp Leu Asp Gly Leu Glu Lys Ala Leu Gln Arg Ala
145                 150                 155                 160 
Val Phe Gly Gln Pro Ala Ala Val Ser Arg Ile Val Ala Leu Met Arg
                165                 170                 175     
Asp Tyr Leu Ala Thr His Val His Ser Arg Pro Leu Leu Leu Ala Leu
            180                 185                 190         
His Gly Pro Ser Gly Val Gly Lys Ser His Val Gly Arg Leu Leu Ala
        195                 200                 205             
Arg His Phe Arg Ser Val Leu Glu Asp Ser Ala Leu Val Leu Gln Tyr
    210                 215                 220                 
His Ala Arg His His Cys Pro Glu Ala Arg Ala Ala Gln Asp Cys Arg
225                 230                 235                 240 
Glu Glu Leu Ala Arg Arg Val Ala Asp Val Val Ala Arg Ala Glu Ala
                245                 250                 255     
Glu Glu Lys Thr Pro Leu Leu Val Leu Asp Asp Val Glu Leu Met Pro
            260                 265                 270         
Arg Pro Leu Leu Asp Glu Leu His Gly Phe Leu Gln Pro Gln Arg Ser
        275                 280                 285             
His His Phe His Asn Ala Ile Tyr Val Leu Leu Ser Gly Ala Gly Gly
    290                 295                 300                 
Ala Glu Val Thr Arg Phe Val Leu Gln Asn Ala Ser Arg Ala Leu Pro
305                 310                 315                 320 
Leu Arg Pro Asp Gly Phe Arg Ser Ala Glu Ala Ala Ala Ala Gln Ala
                325                 330                 335     
Glu Glu Asp Leu Arg Ala Ser Leu Leu Ala Val Leu Ser Arg Glu His
            340                 345                 350         
Pro Leu Trp Arg Ala Ala Ala Ile Val Pro Phe Leu Leu Leu Asp Lys
        355                 360                 365             
Arg Asp Val Val Ser Cys Phe Arg Asp Glu Met Ala Gly Glu Gly Phe
    370                 375                 380                 
Phe Pro Asp Gln Ala Arg Ala Glu Asn Leu Ala Ala Gln Leu Ser Phe
385                 390                 395                 400 
Tyr Arg Val Ala Gly Arg Glu Phe Ala Val Thr Gly Cys Lys Gln Val
                405                 410                 415     
Val Ala Thr Val Asn Leu Leu
            420             


<210> 950
<211> 412
<212> PRT
<213> Homo sapiens

<400> 950
Met Asp Thr Met Ala Phe Ser Leu Thr Val Pro Thr Leu Ala Leu Lys
 1               5                  10                  15      
Met Pro Asn Gly Leu Asp Gly Met Ser Leu Ser Pro Pro Gly Ala Arg
            20                  25                  30          
Val Pro Leu His Tyr Leu Glu Thr Glu Leu Glu Asp Pro Phe Ala Phe
        35                  40                  45              
Asn Glu Glu Asp Asp Asp Leu Lys Lys Gly Ala Thr Val Arg Lys Lys
    50                  55                  60                  
Leu Gln Ser Lys Leu Ala Gln Asn Arg Gln Arg Gln Arg Glu Thr Glu
65                  70                  75                  80  
Ile Leu Lys Val Arg Gln Glu His Phe Ser Pro Pro Pro Ala Pro Ser
                85                  90                  95      
Gln Gln Gln Pro Pro Gln Gln His Ser His Leu Ser Pro Leu Ser Thr
            100                 105                 110         
Ser Leu Lys Pro Pro Ala Pro Pro Gln Gly Ser Val Cys Lys Ser Pro
        115                 120                 125             
Gln Pro Gln Asn Thr Ser Leu Pro Met Gln Gly Val Ala Pro Thr Thr
    130                 135                 140                 
His Thr Ile Ala Gln Ala Arg Gln Leu Ser His Lys Arg Pro Leu Pro
145                 150                 155                 160 
Leu Leu Pro Ser Ser Arg Ala Pro Thr Val Asp Pro Pro Arg Thr Asp
                165                 170                 175     
Arg Ile Leu Met Lys Ala Thr Ala Phe Ser Pro His Phe Ser Cys Ile
            180                 185                 190         
Ser Arg Leu Gln Arg Leu Val Lys Leu Cys Thr Gln Lys His Gln Leu
        195                 200                 205             
Asp Thr Asp Leu Phe Pro His Leu Gly Leu Asp Trp Ser Glu Glu Ser
    210                 215                 220                 
Gly Glu Glu Pro Glu Asp Ser Glu Gln Ala Ser Pro Tyr Gln Val Ala
225                 230                 235                 240 
Trp Ser Ile Arg Glu Thr Leu Arg Tyr Gln Arg His Val Ser Asp Asp
                245                 250                 255     
Asp Asp Ala Glu Ser Arg Ser Ser Arg Val Thr Gln Leu Cys Thr Tyr
            260                 265                 270         
Phe Gln Gln Lys Tyr Lys His Leu Cys Arg Leu Glu Arg Ala Glu Ser
        275                 280                 285             
Arg Gln Lys Lys Cys Arg His Thr Phe Arg Lys Ala Leu Leu Gln Ala
    290                 295                 300                 
Ala Ser Lys Glu Pro Glu Cys Thr Gly Gln Leu Ile Gln Glu Leu Arg
305                 310                 315                 320 
Arg Ala Ala Cys Ser Arg Thr Ser Ile Ser Arg Thr Lys Leu Arg Glu
                325                 330                 335     
Val Glu Pro Ala Ala Cys Ser Gly Thr Val Lys Gly Glu Gln Cys Ala
            340                 345                 350         
Asn Lys Ala Leu Pro Phe Thr Arg His Cys Phe Gln His Ile Leu Leu
        355                 360                 365             
Asn His Ser Gln Gln Leu Phe Ser Ser Cys Thr Ala Lys Phe Ala Asp
    370                 375                 380                 
Gly Gln Gln Cys Ser Val Pro Val Phe Asp Ile Thr His Gln Thr Pro
385                 390                 395                 400 
Leu Cys Glu Glu His Ala Lys Lys Trp Ile Ile Pro
                405                 410         


<210> 951
<211> 227
<212> PRT
<213> Homo sapiens

<400> 951
Met Gly Gly Thr Thr Ser Thr Arg Arg Val Thr Phe Glu Ala Asp Glu
 1               5                  10                  15      
Asn Glu Asn Ile Thr Val Val Lys Gly Ile Arg Leu Ser Glu Asn Val
            20                  25                  30          
Ile Asp Arg Met Lys Glu Ser Ser Pro Ser Gly Ser Lys Ser Gln Arg
        35                  40                  45              
Tyr Ser Gly Ala Tyr Gly Ala Ser Val Ser Asp Glu Glu Leu Lys Arg
    50                  55                  60                  
Arg Val Ala Glu Glu Leu Ala Leu Glu Gln Ala Lys Lys Glu Ser Glu
65                  70                  75                  80  
Asp Gln Lys Arg Leu Lys Gln Ala Lys Glu Leu Asp Arg Glu Arg Ala
                85                  90                  95      
Ala Ala Asn Glu Gln Leu Thr Arg Ala Ile Leu Arg Glu Arg Ile Cys
            100                 105                 110         
Ser Glu Glu Glu Arg Ala Lys Ala Lys His Leu Ala Arg Gln Leu Glu
        115                 120                 125             
Glu Lys Asp Arg Val Leu Lys Lys Gln Asp Ala Phe Tyr Lys Glu Gln
    130                 135                 140                 
Leu Ala Arg Leu Glu Glu Arg Ser Ser Glu Phe Tyr Arg Val Thr Thr
145                 150                 155                 160 
Glu Gln Tyr Gln Lys Ala Ala Glu Glu Val Glu Ala Lys Phe Lys Arg
                165                 170                 175     
Tyr Glu Ser His Pro Val Cys Ala Asp Leu Gln Ala Lys Ile Leu Gln
            180                 185                 190         
Cys Tyr Arg Glu Asn Thr His Gln Thr Leu Lys Cys Ser Ala Leu Ala
        195                 200                 205             
Thr Gln Tyr Met His Cys Val Asn His Ala Lys Gln Ser Met Leu Glu
    210                 215                 220                 
Lys Gly Gly
225         


<210> 952
<211> 227
<212> PRT
<213> Homo sapiens

<400> 952
Met Gly Gly Thr Thr Ser Thr Arg Arg Val Thr Phe Glu Ala Asp Glu
 1               5                  10                  15      
Asn Glu Asn Ile Thr Val Val Lys Gly Ile Arg Leu Ser Glu Asn Val
            20                  25                  30          
Ile Asp Arg Met Lys Glu Ser Ser Pro Ser Gly Ser Lys Ser Gln Arg
        35                  40                  45              
Tyr Ser Gly Ala Tyr Gly Ala Ser Val Ser Asp Glu Glu Leu Lys Arg
    50                  55                  60                  
Arg Val Ala Glu Glu Leu Ala Leu Glu Gln Ala Lys Lys Glu Ser Glu
65                  70                  75                  80  
Asp Gln Lys Arg Leu Lys Gln Ala Lys Glu Leu Asp Arg Glu Arg Ala
                85                  90                  95      
Ala Ala Asn Glu Gln Leu Thr Arg Ala Ile Leu Arg Glu Arg Ile Cys
            100                 105                 110         
Ser Glu Glu Glu Arg Ala Lys Ala Lys His Leu Ala Arg Gln Leu Glu
        115                 120                 125             
Glu Lys Asp Arg Val Leu Lys Lys Gln Asp Ala Phe Tyr Lys Glu Gln
    130                 135                 140                 
Leu Ala Arg Leu Glu Glu Arg Ser Ser Glu Phe Tyr Arg Val Thr Thr
145                 150                 155                 160 
Glu Gln Tyr Gln Lys Ala Ala Glu Glu Val Glu Ala Lys Phe Lys Arg
                165                 170                 175     
Tyr Glu Ser His Pro Val Cys Ala Asp Leu Gln Ala Lys Ile Leu Gln
            180                 185                 190         
Cys Tyr Arg Glu Asn Thr His Gln Thr Leu Lys Cys Ser Ala Leu Ala
        195                 200                 205             
Thr Gln Tyr Met His Cys Val Asn His Ala Lys Gln Ser Met Leu Glu
    210                 215                 220                 
Lys Gly Gly
225         


<210> 953
<211> 278
<212> PRT
<213> Homo sapiens

<400> 953
Met Pro Asp Gln Ala Leu Gln Gln Met Leu Asp Arg Ser Cys Trp Val
 1               5                  10                  15      
Cys Phe Ala Thr Asp Glu Asp Asp Arg Thr Ala Glu Trp Val Arg Pro
            20                  25                  30          
Cys Arg Cys Arg Gly Ser Thr Lys Trp Val His Gln Ala Cys Leu Gln
        35                  40                  45              
Arg Trp Val Asp Glu Lys Gln Arg Gly Asn Ser Thr Ala Arg Val Ala
    50                  55                  60                  
Cys Pro Gln Cys Asn Ala Glu Tyr Leu Ile Val Phe Pro Lys Leu Gly
65                  70                  75                  80  
Pro Val Val Tyr Val Leu Asp Leu Ala Asp Arg Leu Ile Ser Lys Ala
                85                  90                  95      
Cys Pro Phe Ala Ala Ala Gly Ile Met Val Gly Ser Ile Tyr Trp Thr
            100                 105                 110         
Ala Val Thr Tyr Gly Ala Val Thr Val Met Gln Val Val Gly His Lys
        115                 120                 125             
Glu Gly Leu Asp Val Met Glu Arg Ala Asp Pro Leu Phe Leu Leu Ile
    130                 135                 140                 
Gly Leu Pro Thr Ile Pro Val Met Leu Ile Leu Gly Lys Met Ile Arg
145                 150                 155                 160 
Trp Glu Asp Tyr Val Leu Arg Leu Trp Arg Lys Tyr Ser Asn Lys Leu
                165                 170                 175     
Gln Ile Leu Asn Ser Ile Phe Pro Gly Ile Gly Cys Pro Val Pro Arg
            180                 185                 190         
Ile Pro Ala Glu Ala Asn Pro Leu Ala Asp His Val Ser Ala Thr Arg
        195                 200                 205             
Ile Leu Cys Gly Ala Leu Val Phe Pro Thr Ile Ala Thr Ile Val Gly
    210                 215                 220                 
Lys Leu Met Phe Ser Ser Val Asn Ser Asn Leu Gln Arg Thr Ile Leu
225                 230                 235                 240 
Gly Gly Ile Ala Phe Val Ala Ile Lys Gly Ala Phe Lys Val Tyr Phe
                245                 250                 255     
Lys Gln Gln Gln Tyr Leu Arg Gln Ala His Arg Lys Ile Leu Asn Tyr
            260                 265                 270         
Pro Glu Gln Glu Glu Ala
        275             


<210> 954
<211> 363
<212> PRT
<213> Homo sapiens

<400> 954
Met Ala Ala Ala Ala Met Ala Ala Ala Ala Gly Gly Gly Ala Gly Ala
 1               5                  10                  15      
Ala Arg Ser Leu Ser Arg Phe Arg Gly Cys Leu Ala Gly Ala Leu Leu
            20                  25                  30          
Gly Asp Cys Val Gly Ser Phe Tyr Glu Ala His Asp Thr Val Asp Leu
        35                  40                  45              
Thr Ser Val Leu Arg His Val Gln Ser Leu Glu Pro Asp Pro Gly Thr
    50                  55                  60                  
Pro Gly Ser Glu Arg Thr Glu Ala Leu Tyr Tyr Thr Asp Asp Thr Ala
65                  70                  75                  80  
Met Ala Arg Ala Leu Val Gln Ser Leu Leu Ala Lys Glu Ala Phe Asp
                85                  90                  95      
Glu Val Asp Met Ala His Arg Phe Ala Gln Glu Tyr Lys Lys Asp Pro
            100                 105                 110         
Asp Arg Gly Tyr Gly Ala Gly Val Val Thr Val Phe Lys Lys Leu Leu
        115                 120                 125             
Asn Pro Lys Cys Arg Asp Val Phe Glu Pro Ala Arg Ala Gln Phe Asn
    130                 135                 140                 
Gly Lys Gly Ser Tyr Gly Asn Gly Gly Ala Met Arg Val Ala Gly Ile
145                 150                 155                 160 
Ser Leu Ala Tyr Ser Ser Val Gln Asp Val Gln Lys Phe Ala Arg Leu
                165                 170                 175     
Ser Ala Gln Leu Thr His Ala Ser Ser Leu Gly Tyr Asn Gly Ala Ile
            180                 185                 190         
Leu Gln Ala Leu Ala Val His Leu Ala Leu Gln Gly Glu Ser Ser Ser
        195                 200                 205             
Glu His Phe Leu Lys Gln Leu Leu Gly His Met Glu Asp Leu Glu Gly
    210                 215                 220                 
Asp Ala Gln Ser Val Leu Asp Ala Arg Glu Leu Gly Met Glu Glu Arg
225                 230                 235                 240 
Pro Tyr Ser Ser Arg Leu Lys Lys Ile Gly Glu Leu Leu Asp Gln Ala
                245                 250                 255     
Ser Val Thr Arg Glu Glu Val Val Ser Glu Leu Gly Asn Gly Ile Ala
            260                 265                 270         
Ala Phe Glu Ser Val Pro Thr Ala Ile Tyr Cys Phe Leu Arg Cys Met
        275                 280                 285             
Glu Pro Asp Pro Glu Ile Pro Ser Ala Phe Asn Ser Leu Gln Arg Thr
    290                 295                 300                 
Leu Ile Tyr Ser Ile Ser Leu Gly Gly Asp Thr Asp Thr Ile Ala Thr
305                 310                 315                 320 
Met Ala Gly Ala Ile Ala Gly Ala Tyr Tyr Gly Met Asp Gln Val Pro
                325                 330                 335     
Glu Ser Trp Gln Gln Ser Cys Glu Gly Tyr Glu Glu Thr Asp Ile Leu
            340                 345                 350         
Ala Gln Ser Leu His Arg Val Phe Gln Lys Ser
        355                 360             


<210> 955
<211> 574
<212> PRT
<213> Homo sapiens

<400> 955
Met Glu Pro Asn Ser Leu Arg Thr Lys Val Pro Ala Phe Leu Ser Asp
 1               5                  10                  15      
Leu Gly Lys Ala Thr Leu Arg Gly Ile Arg Lys Cys Pro Arg Cys Gly
            20                  25                  30          
Thr Tyr Asn Gly Thr Arg Gly Leu Ser Cys Lys Asn Lys Thr Cys Gly
        35                  40                  45              
Thr Ile Phe Arg Tyr Gly Ala Arg Lys Gln Pro Ser Val Glu Ala Val
    50                  55                  60                  
Lys Ile Ile Thr Gly Ser Asp Leu Gln Val Tyr Ser Val Arg Gln Arg
65                  70                  75                  80  
Asp Arg Gly Pro Asp Tyr Arg Cys Phe Val Glu Leu Gly Val Ser Glu
                85                  90                  95      
Thr Thr Ile Gln Thr Val Asp Gly Thr Ile Ile Thr Gln Leu Ser Ser
            100                 105                 110         
Gly Arg Cys Tyr Val Pro Ser Cys Leu Lys Ala Ala Thr Gln Gly Val
        115                 120                 125             
Val Glu Asn Gln Cys Gln His Ile Lys Leu Ala Val Asn Cys Gln Ala
    130                 135                 140                 
Glu Ala Thr Pro Leu Thr Leu Lys Ser Ser Val Leu Asn Ala Met Gln
145                 150                 155                 160 
Ala Ser Pro Glu Thr Lys Gln Thr Ile Trp Gln Leu Ala Thr Glu Pro
                165                 170                 175     
Thr Gly Pro Leu Val Gln Arg Ile Thr Lys Asn Ile Leu Val Val Lys
            180                 185                 190         
Cys Lys Ala Ser Gln Lys His Ser Leu Gly Tyr Leu His Thr Ser Phe
        195                 200                 205             
Val Gln Lys Val Ser Gly Lys Ser Leu Pro Glu Arg Arg Phe Phe Cys
    210                 215                 220                 
Ser Cys Gln Thr Leu Lys Ser His Lys Ser Asn Ala Ser Lys Asp Glu
225                 230                 235                 240 
Thr Ala Gln Arg Cys Ile His Phe Phe Ala Cys Ile Cys Ala Phe Ala
                245                 250                 255     
Ser Asp Glu Thr Leu Ala Gln Glu Phe Ser Asp Phe Leu Asn Phe Asp
            260                 265                 270         
Ser Ser Gly Leu Lys Glu Ile Ile Val Pro Gln Leu Gly Cys His Ser
        275                 280                 285             
Glu Ser Thr Val Ser Ala Cys Glu Ser Thr Ala Ser Lys Ser Lys Lys
    290                 295                 300                 
Arg Arg Lys Asp Glu Val Ser Gly Ala Gln Met Asn Ser Ser Leu Leu
305                 310                 315                 320 
Pro Gln Asp Ala Val Ser Ser Asn Leu Arg Lys Ser Gly Leu Lys Lys
                325                 330                 335     
Pro Val Val Ala Ser Ser Leu Lys Arg Gln Ala Cys Gly Gln Leu Leu
            340                 345                 350         
Asp Glu Ala Gln Val Thr Leu Ser Phe Gln Asp Trp Leu Ala Ser Val
        355                 360                 365             
Thr Glu Arg Ile His Gln Thr Met His Tyr Gln Phe Asp Gly Lys Pro
    370                 375                 380                 
Glu Pro Leu Val Phe His Ile Pro Gln Ser Phe Phe Asp Ala Leu Gln
385                 390                 395                 400 
Gln Arg Ile Ser Ile Gly Ser Ala Lys Lys Arg Leu Pro Asn Ser Thr
                405                 410                 415     
Thr Ala Phe Val Arg Lys Asp Ala Leu Pro Leu Gly Thr Phe Ser Lys
            420                 425                 430         
Tyr Thr Trp His Ile Thr Asn Ile Leu Gln Val Lys Gln Ile Leu Asp
        435                 440                 445             
Thr Pro Glu Met Pro Leu Glu Ile Thr Arg Ser Phe Ile Gln Asn Arg
    450                 455                 460                 
Asp Gly Thr Tyr Glu Leu Phe Lys Cys Pro Lys Val Glu Val Glu Ser
465                 470                 475                 480 
Ile Ala Glu Thr Tyr Gly Arg Ile Glu Lys Gln Pro Val Leu Arg Pro
                485                 490                 495     
Leu Glu Leu Lys Thr Phe Leu Lys Val Gly Asn Thr Ser Pro Asp Gln
            500                 505                 510         
Lys Glu Pro Thr Pro Phe Ile Ile Glu Trp Ile Pro Asp Ile Leu Pro
        515                 520                 525             
Gln Ser Lys Ile Gly Glu Leu Arg Ile Lys Phe Glu Tyr Gly His His
    530                 535                 540                 
Arg Asn Gly His Val Ala Glu Tyr Gln Asp Gln Arg Pro Pro Leu Asp
545                 550                 555                 560 
Gln Pro Leu Glu Leu Ala Pro Leu Thr Thr Ile Thr Phe Pro
                565                 570                 


<210> 956
<211> 550
<212> PRT
<213> Homo sapiens

<400> 956
Met Ala Phe Ser Lys Leu Leu Glu Gln Ala Gly Gly Val Gly Leu Phe
 1               5                  10                  15      
Gln Thr Leu Gln Val Leu Thr Phe Ile Leu Pro Cys Leu Met Ile Pro
            20                  25                  30          
Ser Gln Met Leu Leu Glu Asn Phe Ser Ala Ala Ile Pro Gly His Arg
        35                  40                  45              
Cys Trp Thr His Met Leu Asp Asn Gly Ser Ala Val Ser Thr Asn Met
    50                  55                  60                  
Thr Pro Lys Ala Leu Leu Thr Ile Ser Ile Pro Pro Gly Pro Asn Gln
65                  70                  75                  80  
Gly Pro His Gln Cys Arg Arg Phe Arg Gln Pro Gln Trp Gln Leu Leu
                85                  90                  95      
Asp Pro Asn Ala Thr Ala Thr Ser Trp Ser Glu Ala Asp Thr Glu Pro
            100                 105                 110         
Cys Val Asp Gly Trp Val Tyr Asp Arg Ser Val Phe Thr Ser Thr Ile
        115                 120                 125             
Val Ala Lys Trp Asp Leu Val Cys Ser Ser Gln Gly Leu Lys Pro Leu
    130                 135                 140                 
Ser Gln Ser Ile Phe Met Ser Gly Ile Leu Val Gly Ser Phe Ile Trp
145                 150                 155                 160 
Gly Leu Leu Ser Tyr Arg Phe Gly Arg Lys Pro Met Leu Ser Trp Cys
                165                 170                 175     
Cys Leu Gln Leu Ala Val Ala Gly Thr Ser Thr Ile Phe Ala Pro Thr
            180                 185                 190         
Phe Val Ile Tyr Cys Gly Leu Arg Phe Val Ala Ala Phe Gly Met Ala
        195                 200                 205             
Gly Ile Phe Leu Ser Ser Leu Thr Leu Met Val Glu Trp Thr Thr Thr
    210                 215                 220                 
Ser Arg Arg Ala Val Thr Met Thr Val Val Gly Cys Ala Phe Ser Ala
225                 230                 235                 240 
Gly Gln Ala Ala Leu Gly Gly Leu Ala Phe Ala Leu Arg Asp Trp Arg
                245                 250                 255     
Thr Leu Gln Leu Ala Ala Ser Val Pro Phe Phe Ala Ile Ser Leu Ile
            260                 265                 270         
Ser Trp Trp Leu Pro Glu Ser Ala Arg Trp Leu Ile Ile Lys Gly Lys
        275                 280                 285             
Pro Asp Gln Ala Leu Gln Glu Leu Arg Lys Val Ala Arg Ile Asn Gly
    290                 295                 300                 
His Lys Glu Ala Lys Asn Leu Thr Ile Glu Val Leu Met Ser Ser Val
305                 310                 315                 320 
Lys Glu Glu Val Ala Ser Ala Lys Glu Pro Arg Ser Val Leu Asp Leu
                325                 330                 335     
Phe Cys Val Pro Val Leu Arg Trp Arg Ser Cys Ala Met Leu Val Val
            340                 345                 350         
Asn Phe Ser Leu Leu Ile Ser Tyr Tyr Gly Leu Val Phe Asp Leu Gln
        355                 360                 365             
Ser Leu Gly Arg Asp Ile Phe Leu Leu Gln Ala Leu Phe Gly Ala Val
    370                 375                 380                 
Asp Phe Leu Gly Arg Ala Thr Thr Ala Leu Leu Leu Ser Phe Leu Gly
385                 390                 395                 400 
Arg Arg Thr Ile Gln Ala Gly Ser Gln Ala Met Ala Gly Leu Ala Ile
                405                 410                 415     
Leu Ala Asn Met Leu Val Pro Gln Asp Leu Gln Thr Leu Arg Val Val
            420                 425                 430         
Phe Ala Val Leu Gly Lys Gly Cys Phe Gly Ile Ser Leu Thr Cys Leu
        435                 440                 445             
Thr Ile Tyr Lys Ala Glu Leu Phe Pro Thr Pro Val Arg Met Thr Ala
    450                 455                 460                 
Asp Gly Ile Leu His Thr Val Gly Arg Leu Gly Ala Met Met Gly Pro
465                 470                 475                 480 
Leu Ile Leu Met Ser Arg Gln Ala Leu Pro Leu Leu Pro Pro Leu Leu
                485                 490                 495     
Tyr Gly Val Ile Ser Ile Ala Ser Ser Leu Val Val Leu Phe Phe Leu
            500                 505                 510         
Pro Glu Thr Gln Gly Leu Pro Leu Pro Asp Thr Ile Gln Asp Leu Glu
        515                 520                 525             
Ser Gln Lys Ser Thr Ala Ala Gln Gly Asn Arg Gln Glu Ala Val Thr
    530                 535                 540                 
Val Glu Ser Thr Ser Leu
545                 550 


<210> 957
<211> 108
<212> PRT
<213> Homo sapiens

<400> 957
Met Ser Leu Thr Ser Ser Ser Ser Val Arg Val Glu Trp Ile Ala Ala
 1               5                  10                  15      
Val Thr Ile Ala Ala Gly Thr Ala Ala Ile Gly Tyr Leu Ala Tyr Lys
            20                  25                  30          
Arg Phe Tyr Val Lys Asp His Arg Asn Lys Ala Met Ile Asn Leu His
        35                  40                  45              
Ile Gln Lys Asp Asn Pro Lys Ile Val His Ala Phe Asp Met Glu Asp
    50                  55                  60                  
Leu Gly Asp Lys Ala Val Tyr Cys Arg Cys Trp Arg Ser Lys Lys Phe
65                  70                  75                  80  
Pro Phe Cys Asp Gly Ala His Thr Lys His Asn Glu Glu Thr Gly Asp
                85                  90                  95      
Asn Val Gly Pro Leu Ile Ile Lys Lys Lys Glu Thr
            100                 105             


<210> 958
<211> 108
<212> PRT
<213> Homo sapiens

<400> 958
Met Ser Leu Thr Ser Ser Ser Ser Val Arg Val Glu Trp Ile Ala Ala
 1               5                  10                  15      
Val Thr Ile Ala Ala Gly Thr Ala Ala Ile Gly Tyr Leu Ala Tyr Lys
            20                  25                  30          
Arg Phe Tyr Val Lys Asp His Arg Asn Lys Ala Met Ile Asn Leu His
        35                  40                  45              
Ile Gln Lys Asp Asn Pro Lys Ile Val His Ala Phe Asp Met Glu Asp
    50                  55                  60                  
Leu Gly Asp Lys Ala Val Tyr Cys Arg Cys Trp Arg Ser Lys Lys Phe
65                  70                  75                  80  
Pro Phe Cys Asp Gly Ala His Thr Lys His Asn Glu Glu Thr Gly Asp
                85                  90                  95      
Asn Val Gly Pro Leu Ile Ile Lys Lys Lys Glu Thr
            100                 105             


<210> 959
<211> 386
<212> PRT
<213> Homo sapiens

<400> 959
Pro Gly Lys Leu Phe Ile Gly Gly Leu Asn Leu Glu Thr Asp Glu Lys
 1               5                  10                  15      
Ala Leu Glu Ala Glu Phe Gly Lys Tyr Gly Arg Ile Val Glu Val Leu
            20                  25                  30          
Leu Met Lys Asp Arg Glu Thr Asn Lys Ser Arg Gly Phe Ala Phe Val
        35                  40                  45              
Thr Phe Glu Ser Pro Ala Asp Ala Lys Ala Ala Val Arg Asp Met Asn
    50                  55                  60                  
Gly Lys Ser Leu Asp Gly Lys Ala Ile Lys Val Ala Gln Ala Thr Lys
65                  70                  75                  80  
Pro Ala Phe Glu Ser Ser Arg Arg Gly Pro Pro Pro Pro Arg Ser Arg
                85                  90                  95      
Gly Arg Pro Arg Phe Leu Arg Gly Thr Arg Gly Gly Gly Gly Gly Pro
            100                 105                 110         
Arg Arg Ser Pro Ser Arg Gly Gly Pro Asp Asp Asp Gly Gly Tyr Ala
        115                 120                 125             
Ala Asp Phe Asp Leu Arg Pro Ser Arg Ala Pro Met Pro Met Lys Arg
    130                 135                 140                 
Gly Pro Pro Pro Arg Arg Val Gly Pro Pro Pro Lys Arg Ala Ala Pro
145                 150                 155                 160 
Ser Gly Pro Ala Arg Ser Ser Gly Gly Gly Met Arg Gly Arg Ala Leu
                165                 170                 175     
Ala Val Arg Gly Arg Asp Gly Tyr Ser Gly Pro Pro Arg Arg Glu Pro
            180                 185                 190         
Leu Pro Pro Arg Arg Asp Pro Tyr Leu Gly Pro Arg Asp Glu Gly Tyr
        195                 200                 205             
Ser Ser Arg Asp Gly Tyr Ser Ser Arg Asp Tyr Arg Glu Pro Arg Gly
    210                 215                 220                 
Phe Ala Pro Ser Pro Gly Glu Tyr Thr His Arg Asp Tyr Gly His Ser
225                 230                 235                 240 
Ser Val Arg Asp Asp Cys Pro Leu Arg Gly Tyr Ser Asp Arg Asp Gly
                245                 250                 255     
Tyr Gly Gly Arg Asp Arg Asp Tyr Gly Asp His Leu Ser Arg Gly Ser
            260                 265                 270         
His Arg Glu Pro Phe Glu Ser Tyr Gly Glu Leu Arg Gly Ala Ala Pro
        275                 280                 285             
Gly Arg Gly Thr Pro Pro Ser Tyr Gly Gly Gly Gly Arg Tyr Glu Glu
    290                 295                 300                 
Tyr Arg Gly Tyr Ser Pro Asp Ala Tyr Ser Gly Gly Arg Asp Ser Tyr
305                 310                 315                 320 
Ser Ser Ser Tyr Gly Arg Ser Asp Arg Tyr Ser Arg Gly Arg His Arg
                325                 330                 335     
Val Gly Arg Pro Asp Arg Gly Leu Ser Leu Ser Met Glu Arg Gly Cys
            340                 345                 350         
Pro Pro Gln Arg Asp Ser Tyr Ser Arg Ser Gly Cys Arg Val Pro Arg
        355                 360                 365             
Gly Gly Gly Arg Leu Gly Gly Arg Leu Glu Arg Gly Gly Gly Arg Ser
    370                 375                 380                 
Arg Tyr
385     


<210> 960
<211> 493
<212> PRT
<213> Homo sapiens

<400> 960
Met Arg Gly Phe Gly Pro Gly Leu Thr Ala Arg Arg Leu Leu Pro Leu
 1               5                  10                  15      
Arg Leu Pro Pro Arg Pro Pro Gly Pro Arg Leu Ala Ser Gly Gln Ala
            20                  25                  30          
Ala Gly Ala Leu Glu Arg Ala Met Asp Glu Leu Leu Arg Arg Ala Val
        35                  40                  45              
Pro Pro Thr Pro Ala Tyr Glu Leu Arg Glu Lys Thr Pro Ala Pro Ala
    50                  55                  60                  
Glu Gly Gln Cys Ala Asp Phe Val Ser Phe Tyr Gly Gly Leu Ala Glu
65                  70                  75                  80  
Thr Ala Gln Arg Ala Glu Leu Leu Gly Arg Leu Ala Arg Gly Phe Gly
                85                  90                  95      
Val Asp His Gly Gln Val Ala Glu Gln Ser Ala Gly Val Leu His Leu
            100                 105                 110         
Arg Gln Gln Gln Arg Glu Ala Ala Val Leu Leu Gln Ala Glu Asp Arg
        115                 120                 125             
Leu Arg Tyr Ala Leu Val Pro Arg Tyr Arg Gly Leu Phe His His Ile
    130                 135                 140                 
Ser Lys Leu Asp Gly Gly Val Arg Phe Leu Val Gln Leu Arg Ala Asp
145                 150                 155                 160 
Leu Leu Glu Ala Gln Ala Leu Lys Leu Val Glu Gly Pro Asp Val Arg
                165                 170                 175     
Glu Met Asn Gly Val Leu Lys Gly Met Leu Ser Glu Trp Phe Ser Ser
            180                 185                 190         
Gly Phe Leu Asn Leu Glu Arg Val Thr Trp His Ser Pro Cys Glu Val
        195                 200                 205             
Leu Gln Lys Ile Ser Glu Ala Glu Ala Val His Pro Val Lys Asn Trp
    210                 215                 220                 
Met Asp Met Lys Arg Arg Val Gly Pro Tyr Arg Arg Cys Tyr Phe Phe
225                 230                 235                 240 
Ser His Cys Ser Thr Pro Gly Glu Pro Leu Val Val Leu His Val Ala
                245                 250                 255     
Leu Thr Gly Asp Ile Ser Ser Asn Ile Gln Ala Ile Val Lys Glu His
            260                 265                 270         
Pro Pro Ser Glu Thr Glu Glu Lys Asn Lys Ile Thr Ala Ala Ile Phe
        275                 280                 285             
Tyr Ser Ile Ser Leu Thr Gln Gln Gly Leu Gln Gly Val Glu Leu Gly
    290                 295                 300                 
Thr Phe Leu Ile Lys Arg Val Val Lys Glu Leu Gln Arg Glu Phe Pro
305                 310                 315                 320 
His Leu Gly Val Phe Ser Ser Leu Ser Pro Ile Pro Gly Phe Thr Lys
                325                 330                 335     
Trp Leu Leu Gly Leu Leu Asn Ser Gln Thr Lys Glu His Gly Arg Asn
            340                 345                 350         
Glu Leu Phe Thr Asp Ser Glu Cys Lys Glu Ile Ser Glu Ile Thr Gly
        355                 360                 365             
Gly Pro Ile Asn Glu Thr Leu Lys Leu Leu Leu Ser Ser Ser Glu Trp
    370                 375                 380                 
Val Gln Ser Glu Lys Leu Val Arg Ala Leu Gln Thr Pro Leu Met Arg
385                 390                 395                 400 
Leu Cys Ala Trp Tyr Leu Tyr Gly Glu Lys His Arg Gly Tyr Ala Leu
                405                 410                 415     
Asn Pro Val Ala Asn Phe His Leu Gln Asn Gly Ala Val Leu Trp Arg
            420                 425                 430         
Ile Asn Trp Met Ala Asp Val Ser Leu Arg Gly Ile Thr Gly Ser Cys
        435                 440                 445             
Gly Leu Met Ala Asn Tyr Arg Tyr Phe Leu Glu Glu Thr Gly Pro Asn
    450                 455                 460                 
Ser Thr Ser Tyr Leu Gly Ser Lys Ile Ile Lys Ala Ser Glu Gln Val
465                 470                 475                 480 
Leu Ser Leu Val Ala Gln Phe Gln Lys Asn Ser Lys Leu
                485                 490             


<210> 961
<211> 725
<212> PRT
<213> Homo sapiens

<400> 961
Met Ala Ala Ala Ser Ala Val Ser Val Leu Leu Val Ala Ala Glu Arg
 1               5                  10                  15      
Asn Arg Trp His Arg Leu Pro Ser Leu Leu Leu Pro Pro Arg Thr Trp
            20                  25                  30          
Val Trp Arg Gln Arg Thr Met Lys Tyr Thr Thr Ala Thr Gly Arg Asn
        35                  40                  45              
Ile Thr Lys Val Leu Ile Ala Asn Arg Gly Glu Ile Ala Cys Arg Val
    50                  55                  60                  
Met Arg Thr Ala Lys Lys Leu Gly Val Gln Thr Val Ala Val Tyr Ser
65                  70                  75                  80  
Glu Ala Asp Arg Asn Ser Met His Val Asp Met Ala Asp Glu Ala Tyr
                85                  90                  95      
Ser Ile Gly Pro Ala Pro Ser Gln Gln Ser Tyr Leu Ser Met Glu Lys
            100                 105                 110         
Ile Ile Gln Val Ala Lys Thr Ser Ala Ala Gln Ala Ile His Pro Gly
        115                 120                 125             
Cys Gly Phe Leu Ser Glu Asn Met Glu Phe Ala Glu Leu Cys Lys Gln
    130                 135                 140                 
Glu Gly Ile Ile Phe Ile Gly Pro Pro Pro Ser Ala Ile Arg Asp Met
145                 150                 155                 160 
Gly Ile Lys Ser Thr Ser Lys Ser Ile Met Ala Ala Ala Gly Val Pro
                165                 170                 175     
Val Val Glu Gly Tyr His Gly Glu Asp Gln Ser Asp Gln Cys Leu Lys
            180                 185                 190         
Glu His Ala Arg Arg Ile Gly Tyr Pro Val Met Ile Lys Ala Val Arg
        195                 200                 205             
Gly Gly Gly Gly Lys Gly Met Arg Ile Val Arg Ser Glu Gln Glu Phe
    210                 215                 220                 
Gln Glu Gln Leu Glu Ser Ala Arg Arg Glu Ala Lys Lys Ser Phe Asn
225                 230                 235                 240 
Asp Asp Ala Met Leu Ile Glu Lys Phe Val Asp Thr Pro Arg His Val
                245                 250                 255     
Glu Val Gln Val Phe Gly Asp His His Gly Asn Ala Val Tyr Leu Phe
            260                 265                 270         
Glu Arg Asp Cys Ser Val Gln Arg Arg His Gln Lys Ile Ile Glu Glu
        275                 280                 285             
Ala Pro Ala Pro Gly Ile Lys Ser Glu Val Arg Lys Lys Leu Gly Glu
    290                 295                 300                 
Ala Ala Val Arg Ala Ala Lys Ala Val Asn Tyr Val Gly Ala Gly Thr
305                 310                 315                 320 
Val Glu Phe Ile Met Asp Ser Lys His Asn Phe Cys Phe Met Glu Met
                325                 330                 335     
Asn Thr Arg Leu Gln Val Glu His Pro Val Thr Glu Met Ile Thr Gly
            340                 345                 350         
Thr Asp Leu Val Glu Trp Gln Leu Arg Ile Ala Ala Gly Glu Lys Ile
        355                 360                 365             
Pro Leu Ser Gln Glu Glu Ile Thr Leu Gln Gly His Ala Phe Glu Ala
    370                 375                 380                 
Arg Ile Tyr Ala Glu Asp Pro Ser Asn Asn Phe Met Pro Val Ala Gly
385                 390                 395                 400 
Pro Leu Val His Leu Ser Thr Pro Arg Ala Asp Pro Ser Thr Arg Ile
                405                 410                 415     
Glu Thr Gly Val Arg Gln Gly Asp Glu Val Ser Val His Tyr Asp Pro
            420                 425                 430         
Met Ile Ala Lys Leu Val Val Trp Ala Ala Asp Arg Gln Ala Ala Leu
        435                 440                 445             
Thr Lys Leu Arg Tyr Ser Leu Arg Gln Tyr Asn Ile Val Gly Leu His
    450                 455                 460                 
Thr Asn Ile Asp Phe Leu Leu Asn Leu Ser Gly His Pro Glu Phe Glu
465                 470                 475                 480 
Ala Gly Asn Val His Thr Asp Phe Ile Pro Gln His His Lys Gln Leu
                485                 490                 495     
Leu Leu Ser Arg Lys Ala Ala Ala Lys Glu Ser Leu Cys Gln Ala Ala
            500                 505                 510         
Leu Gly Leu Ile Leu Lys Glu Lys Ala Met Thr Asp Thr Phe Thr Leu
        515                 520                 525             
Gln Ala His Asp Gln Phe Ser Pro Phe Ser Ser Ser Ser Gly Arg Arg
    530                 535                 540                 
Leu Asn Ile Ser Tyr Thr Arg Asn Met Thr Leu Lys Asp Gly Lys Asn
545                 550                 555                 560 
Asn Val Ala Ile Ala Val Thr Tyr Asn His Asp Gly Ser Tyr Ser Met
                565                 570                 575     
Gln Ile Glu Asp Lys Thr Phe Gln Val Leu Gly Asn Leu Tyr Ser Glu
            580                 585                 590         
Gly Asp Cys Thr Tyr Leu Lys Cys Ser Val Asn Gly Val Ala Ser Lys
        595                 600                 605             
Ala Lys Leu Ile Ile Leu Glu Asn Thr Ile Tyr Leu Phe Ser Lys Glu
    610                 615                 620                 
Gly Ser Ile Glu Ile Asp Ile Pro Val Pro Lys Tyr Leu Ser Ser Val
625                 630                 635                 640 
Ser Ser Gln Glu Thr Gln Gly Gly Pro Leu Ala Pro Met Thr Gly Thr
                645                 650                 655     
Ile Glu Lys Val Phe Val Lys Ala Gly Asp Lys Val Lys Ala Gly Asp
            660                 665                 670         
Ser Leu Met Val Met Ile Ala Met Lys Met Glu His Thr Ile Lys Ser
        675                 680                 685             
Pro Lys Asp Gly Thr Val Lys Lys Val Phe Tyr Arg Glu Gly Ala Gln
    690                 695                 700                 
Ala Asn Arg His Thr Pro Leu Val Glu Phe Glu Glu Glu Glu Ser Asp
705                 710                 715                 720 
Lys Arg Glu Ser Glu
                725 


<210> 962
<211> 787
<212> PRT
<213> Homo sapiens

<400> 962
Met Glu Pro Ala Gly Glu Arg Phe Pro Glu Gln Arg Gln Val Leu Ile
 1               5                  10                  15      
Leu Leu Leu Leu Leu Glu Val Thr Leu Ala Gly Trp Glu Pro Arg Arg
            20                  25                  30          
Tyr Ser Val Met Glu Glu Thr Glu Arg Gly Ser Phe Val Ala Asn Leu
        35                  40                  45              
Ala Asn Asp Leu Gly Leu Gly Val Gly Glu Leu Ala Glu Arg Gly Ala
    50                  55                  60                  
Arg Val Val Ser Glu Asp Asn Glu Gln Gly Leu Gln Leu Asp Leu Gln
65                  70                  75                  80  
Thr Gly Gln Leu Ile Leu Asn Glu Lys Leu Asp Arg Glu Lys Leu Cys
                85                  90                  95      
Gly Pro Thr Glu Pro Cys Ile Met His Phe Gln Val Leu Leu Lys Lys
            100                 105                 110         
Pro Leu Glu Val Phe Arg Ala Glu Leu Leu Val Thr Asp Ile Asn Asp
        115                 120                 125             
His Ser Pro Glu Phe Pro Glu Arg Glu Met Thr Leu Lys Ile Pro Glu
    130                 135                 140                 
Thr Ser Ser Leu Gly Thr Val Phe Pro Leu Lys Lys Ala Arg Asp Leu
145                 150                 155                 160 
Asp Val Gly Ser Asn Asn Val Gln Asn Tyr Asn Ile Ser Pro Asn Ser
                165                 170                 175     
His Phe His Val Ser Thr Arg Thr Arg Gly Asp Gly Arg Lys Tyr Pro
            180                 185                 190         
Glu Leu Val Leu Asp Thr Glu Leu Asp Arg Glu Glu Gln Ala Glu Leu
        195                 200                 205             
Arg Leu Thr Leu Thr Ala Val Asp Gly Gly Ser Pro Pro Arg Ser Gly
    210                 215                 220                 
Thr Val Gln Ile Leu Ile Leu Val Leu Asp Ala Asn Asp Asn Ala Pro
225                 230                 235                 240 
Glu Phe Val Gln Ala Leu Tyr Glu Val Gln Val Pro Glu Asn Ser Pro
                245                 250                 255     
Val Gly Ser Leu Val Val Lys Val Ser Ala Arg Asp Leu Asp Thr Gly
            260                 265                 270         
Thr Asn Gly Glu Ile Ser Tyr Ser Leu Tyr Tyr Ser Ser Gln Glu Ile
        275                 280                 285             
Asp Lys Pro Phe Glu Leu Ser Ser Leu Ser Gly Glu Ile Arg Leu Ile
    290                 295                 300                 
Lys Lys Leu Asp Phe Glu Thr Met Ser Ser Tyr Asp Leu Asp Ile Glu
305                 310                 315                 320 
Ala Ser Asp Gly Gly Gly Leu Ser Gly Lys Cys Ser Val Ser Val Lys
                325                 330                 335     
Val Leu Asp Val Asn Asp Asn Phe Pro Glu Leu Ser Ile Ser Ser Leu
            340                 345                 350         
Thr Ser Pro Ile Pro Glu Asn Ser Pro Glu Thr Glu Val Ala Leu Phe
        355                 360                 365             
Arg Ile Arg Asp Arg Asp Ser Gly Glu Asn Gly Lys Met Ile Cys Ser
    370                 375                 380                 
Ile Gln Asp Asp Val Pro Phe Lys Leu Lys Pro Ser Val Glu Asn Phe
385                 390                 395                 400 
Tyr Arg Leu Val Thr Glu Gly Ala Leu Asp Arg Glu Thr Arg Ala Glu
                405                 410                 415     
Tyr Asn Ile Thr Ile Thr Ile Thr Asp Leu Gly Thr Pro Arg Leu Lys
            420                 425                 430         
Thr Glu Gln Ser Ile Thr Val Leu Val Ser Asp Val Asn Asp Asn Ala
        435                 440                 445             
Pro Ala Phe Thr Gln Thr Ser Tyr Thr Leu Phe Val Arg Glu Asn Asn
    450                 455                 460                 
Ser Pro Ala Leu His Ile Gly Ser Val Ser Ala Thr Asp Arg Asp Ser
465                 470                 475                 480 
Gly Thr Asn Ala Gln Val Thr Tyr Ser Leu Leu Pro Pro Arg Asp Pro
                485                 490                 495     
His Leu Pro Leu Thr Ser Leu Val Ser Ile Asn Thr Asp Asn Gly His
            500                 505                 510         
Leu Phe Ala Leu Gln Ser Leu Asp Tyr Glu Ala Leu Gln Ala Phe Glu
        515                 520                 525             
Phe Arg Val Gly Ala Thr Asp Arg Gly Phe Pro Ala Leu Ser Ser Glu
    530                 535                 540                 
Ala Leu Val Arg Val Leu Val Leu Asp Ala Asn Asp Asn Ser Pro Phe
545                 550                 555                 560 
Val Leu Tyr Pro Leu Gln Asn Gly Ser Ala Pro Cys Thr Glu Leu Val
                565                 570                 575     
Pro Arg Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val
            580                 585                 590         
Asp Gly Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Gln Leu Leu Lys
        595                 600                 605             
Ala Thr Glu Pro Gly Leu Phe Gly Val Trp Ala His Asn Gly Glu Val
    610                 615                 620                 
Arg Thr Ala Arg Leu Leu Ser Glu Arg Asp Val Ala Lys His Arg Leu
625                 630                 635                 640 
Val Val Leu Val Lys Asp Asn Gly Glu Pro Pro Arg Ser Ala Thr Ala
                645                 650                 655     
Thr Leu Gln Val Leu Leu Val Asp Gly Phe Ser Gln Pro Tyr Leu Pro
            660                 665                 670         
Leu Pro Glu Ala Ala Pro Ala Gln Ala Gln Ala Asp Ser Leu Thr Val
        675                 680                 685             
Tyr Leu Val Val Ala Leu Ala Ser Val Ser Ser Leu Phe Leu Phe Ser
    690                 695                 700                 
Val Phe Leu Phe Val Ala Val Arg Leu Cys Arg Arg Ser Arg Ala Ala
705                 710                 715                 720 
Ser Val Gly Arg Cys Ser Val Pro Glu Gly Pro Phe Pro Gly His Leu
                725                 730                 735     
Val Asp Val Ser Gly Thr Gly Thr Leu Ser Gln Ser Tyr Gln Tyr Glu
            740                 745                 750         
Val Cys Leu Thr Gly Gly Ser Glu Ser Asn Asp Phe Lys Phe Leu Lys
        755                 760                 765             
Pro Ile Phe Pro Asn Ile Val Ser Gln Asp Ser Arg Arg Lys Ser Glu
    770                 775                 780                 
Phe Leu Glu
785         


<210> 963
<211> 280
<212> PRT
<213> Homo sapiens

<400> 963
Met Ala Ala Val Val Ala Leu Ser Leu Arg Arg Arg Leu Pro Ala Thr
 1               5                  10                  15      
Thr Leu Gly Gly Ala Cys Leu Gln Ala Ser Arg Gly Ala Gln Thr Ala
            20                  25                  30          
Ala Ala Thr Ala Pro Arg Ile Lys Lys Phe Ala Ile Tyr Arg Trp Asp
        35                  40                  45              
Pro Asp Lys Ala Gly Asp Lys Pro His Met Gln Thr Tyr Lys Val Asp
    50                  55                  60                  
Leu Asn Lys Cys Gly Pro Met Val Leu Asp Ala Leu Ile Lys Ile Lys
65                  70                  75                  80  
Asn Glu Val Asp Ser Thr Leu Thr Phe Arg Arg Ser Cys Arg Glu Gly
                85                  90                  95      
Ile Cys Gly Ser Cys Ala Met Asn Ile Asn Gly Gly Asn Thr Leu Ala
            100                 105                 110         
Cys Thr Arg Arg Ile Asp Thr Asn Leu Asn Lys Val Ser Lys Ile Tyr
        115                 120                 125             
Pro Leu Pro His Met Tyr Val Ile Lys Asp Leu Val Pro Asp Leu Ser
    130                 135                 140                 
Asn Phe Tyr Ala Gln Tyr Lys Ser Ile Glu Pro Tyr Leu Lys Lys Lys
145                 150                 155                 160 
Asp Glu Ser Gln Glu Gly Lys Gln Gln Tyr Leu Gln Ser Ile Glu Glu
                165                 170                 175     
Arg Glu Lys Leu Asp Gly Leu Tyr Glu Cys Ile Leu Cys Ala Cys Cys
            180                 185                 190         
Ser Thr Ser Cys Pro Ser Tyr Trp Trp Asn Gly Asp Lys Tyr Leu Gly
        195                 200                 205             
Pro Ala Val Leu Met Gln Ala Tyr Arg Trp Met Ile Asp Ser Arg Asp
    210                 215                 220                 
Asp Phe Thr Glu Glu Arg Leu Ala Lys Leu Gln Asp Pro Phe Ser Leu
225                 230                 235                 240 
Tyr Arg Cys His Thr Ile Met Asn Cys Thr Arg Thr Cys Pro Lys Gly
                245                 250                 255     
Leu Asn Pro Gly Lys Ala Ile Ala Glu Ile Lys Lys Met Met Ala Thr
            260                 265                 270         
Tyr Lys Glu Lys Lys Ala Ser Val
        275                 280 


<210> 964
<211> 730
<212> PRT
<213> Homo sapiens

<400> 964
Met Ala Ser Gly Arg Gly Ala Ser Ser Arg Trp Phe Phe Thr Arg Glu
 1               5                  10                  15      
Gln Leu Glu Asn Thr Pro Ser Arg Arg Cys Gly Val Glu Ala Asp Lys
            20                  25                  30          
Glu Leu Ser Cys Arg Gln Gln Ala Ala Asn Leu Ile Gln Glu Met Gly
        35                  40                  45              
Gln Arg Leu Asn Val Ser Gln Leu Thr Ile Asn Thr Ala Ile Val Tyr
    50                  55                  60                  
Met His Arg Phe Tyr Met His His Ser Phe Thr Lys Phe Asn Lys Asn
65                  70                  75                  80  
Ile Ile Ser Ser Thr Ala Leu Phe Leu Ala Ala Lys Val Glu Glu Gln
                85                  90                  95      
Ala Arg Lys Leu Glu His Val Ile Lys Val Ala His Ala Cys Leu His
            100                 105                 110         
Pro Leu Glu Pro Leu Leu Asp Thr Lys Cys Asp Ala Tyr Leu Gln Gln
        115                 120                 125             
Thr Gln Glu Leu Val Ile Leu Glu Thr Ile Met Leu Gln Thr Leu Gly
    130                 135                 140                 
Phe Glu Ile Thr Ile Glu His Pro His Thr Asp Val Val Lys Cys Thr
145                 150                 155                 160 
Gln Leu Val Arg Ala Ser Lys Asp Leu Ala Gln Thr Ser Tyr Phe Met
                165                 170                 175     
Ala Thr Asn Ser Leu His Leu Thr Thr Phe Cys Leu Gln Tyr Lys Pro
            180                 185                 190         
Thr Val Ile Ala Cys Val Cys Ile His Leu Ala Cys Lys Trp Ser Asn
        195                 200                 205             
Trp Glu Ile Pro Val Ser Thr Asp Gly Lys His Trp Trp Glu Tyr Val
    210                 215                 220                 
Asp Pro Thr Val Thr Leu Glu Leu Leu Asp Glu Leu Thr His Glu Phe
225                 230                 235                 240 
Leu Gln Ile Leu Glu Lys Thr Pro Asn Arg Leu Lys Lys Ile Arg Asn
                245                 250                 255     
Trp Arg Ala Asn Gln Ala Ala Arg Lys Pro Lys Val Asp Gly Gln Val
            260                 265                 270         
Ser Glu Thr Pro Leu Leu Gly Ser Ser Leu Val Gln Asn Ser Ile Leu
        275                 280                 285             
Val Asp Ser Val Thr Gly Val Pro Thr Asn Pro Ser Phe Gln Lys Pro
    290                 295                 300                 
Ser Thr Ser Ala Phe Pro Ala Pro Val Pro Leu Asn Ser Gly Asn Ile
305                 310                 315                 320 
Ser Val Gln Asp Ser His Thr Ser Asp Asn Leu Ser Met Leu Ala Thr
                325                 330                 335     
Gly Met Pro Ser Thr Ser Tyr Gly Leu Ser Ser His Gln Glu Trp Pro
            340                 345                 350         
Gln His Gln Asp Ser Ala Arg Thr Glu Gln Leu Tyr Ser Gln Lys Gln
        355                 360                 365             
Glu Thr Ser Leu Ser Gly Ser Gln Tyr Asn Ile Asn Phe Gln Gln Gly
    370                 375                 380                 
Pro Ser Ile Ser Leu His Ser Gly Leu His His Arg Pro Asp Lys Ile
385                 390                 395                 400 
Ser Asp His Ser Ser Val Lys Gln Glu Tyr Thr His Lys Ala Gly Ser
                405                 410                 415     
Ser Lys His His Gly Pro Ile Ser Thr Thr Pro Gly Ile Ile Pro Gln
            420                 425                 430         
Lys Met Ser Leu Asp Lys Tyr Arg Glu Lys Arg Lys Leu Glu Thr Leu
        435                 440                 445             
Asp Leu Asp Val Arg Asp His Tyr Ile Ala Ala Gln Val Glu Gln Gln
    450                 455                 460                 
His Lys Gln Gly Gln Ser Gln Ala Ala Ser Ser Ser Ser Val Thr Ser
465                 470                 475                 480 
Pro Ile Lys Met Lys Ile Pro Ile Ala Asn Thr Glu Lys Tyr Met Ala
                485                 490                 495     
Asp Lys Lys Glu Lys Ser Gly Ser Leu Lys Leu Arg Ile Pro Ile Pro
            500                 505                 510         
Pro Thr Asp Lys Ser Ala Ser Lys Glu Glu Leu Lys Met Lys Ile Lys
        515                 520                 525             
Val Ser Ser Ser Glu Arg His Ser Ser Ser Asp Glu Gly Ser Gly Lys
    530                 535                 540                 
Ser Lys His Ser Ser Pro His Ile Ser Arg Asp His Lys Glu Lys His
545                 550                 555                 560 
Lys Glu His Pro Ser Ser Arg His His Thr Ser Ser His Lys His Ser
                565                 570                 575     
His Ser His Ser Gly Ser Ser Ser Gly Gly Ser Lys His Ser Ala Asp
            580                 585                 590         
Gly Ile Pro Pro Thr Val Leu Arg Ser Pro Val Gly Leu Ser Ser Asp
        595                 600                 605             
Gly Ile Ser Ser Ser Ser Ser Ser Ser Arg Lys Arg Leu His Val Asn
    610                 615                 620                 
Asp Ala Ser His Asn His His Ser Lys Met Ser Lys Ser Ser Lys Ser
625                 630                 635                 640 
Ser Gly Ser Ser Ser Ser Ser Ser Ser Ser Val Lys Gln Tyr Ile Ser
                645                 650                 655     
Ser His Asn Ser Val Phe Asn His Pro Leu Pro Pro Pro Pro Pro Val
            660                 665                 670         
Thr Tyr Gln Val Gly Tyr Gly His Leu Cys Thr Leu Val Lys Leu Asp
        675                 680                 685             
Lys Lys Pro Val Glu Thr Asn Gly Pro Asp Ala Asn His Glu Tyr Ser
    690                 695                 700                 
Thr Ser Ser Gln His Met Asp Tyr Lys Asp Thr Phe Asp Met Leu Asp
705                 710                 715                 720 
Ser Leu Leu Ser Ala Gln Gly Met Asn Met
                725                 730 


<210> 965
<211> 63
<212> PRT
<213> Homo sapiens

<400> 965
Met Ala Ala Ala Thr Leu Thr Ser Lys Leu Tyr Ser Leu Leu Phe Arg
 1               5                  10                  15      
Arg Thr Ser Thr Phe Ala Leu Thr Ile Ile Val Gly Val Met Phe Phe
            20                  25                  30          
Glu Arg Ala Phe Asp Gln Gly Ala Asp Ala Ile Tyr Asp His Ile Asn
        35                  40                  45              
Glu Gly Lys Leu Trp Lys His Ile Lys His Lys Tyr Glu Asn Lys
    50                  55                  60              


<210> 966
<211> 205
<212> PRT
<213> Homo sapiens

<400> 966
Met Gly Leu Gly Lys Thr Val Gln Val Ile Ser Phe Leu Ala Ala Val
 1               5                  10                  15      
Leu His Lys Lys Gly Thr Arg Glu Asp Ile Glu Asn Asn Met Pro Glu
            20                  25                  30          
Phe Leu Leu Arg Ser Met Lys Lys Glu Pro Leu Ser Ser Thr Ala Lys
        35                  40                  45              
Lys Met Phe Leu Ile Val Ala Pro Leu Ser Val Leu Tyr Asn Trp Lys
    50                  55                  60                  
Asp Glu Leu Asp Thr Trp Gly Tyr Phe Arg Val Thr Val Leu His Gly
65                  70                  75                  80  
Asn Arg Lys Asp Asn Glu Leu Ile Arg Val Lys Gln Arg Lys Cys Glu
                85                  90                  95      
Ile Ala Leu Thr Thr Tyr Glu Thr Leu Arg Leu Cys Leu Asp Glu Leu
            100                 105                 110         
Asn Ser Leu Glu Trp Ser Ala Val Ile Val Asp Glu Ala His Arg Ile
        115                 120                 125             
Lys Asn Pro Lys Ala Arg Val Thr Glu Val Met Lys Ala Leu Lys Cys
    130                 135                 140                 
Asn Val Arg Ile Gly Leu Thr Gly Thr Ile Leu Gln Asn Asn Met Lys
145                 150                 155                 160 
Glu Leu Trp Cys Val Met Asp Trp Ala Val Pro Gly Leu Leu Gly Ser
                165                 170                 175     
Gly Thr Tyr Phe Lys Lys Gln Phe Ser Asp Pro Val Glu His Gly Gln
            180                 185                 190         
Arg His Thr Ala Thr Lys Arg Glu Leu Ala Thr Gly Arg
        195                 200                 205 


<210> 967
<211> 1211
<212> PRT
<213> Homo sapiens

<400> 967
Met Gly Ser Leu Gln Gly Ile Ala Thr Lys Ile Leu Ile Arg Ile Leu
 1               5                  10                  15      
Ser Asp Ala Leu Ile Arg Lys Glu Thr Asp Leu Lys Ser Ser Thr Ile
            20                  25                  30          
Val Thr Pro Ile Ile Leu Arg Thr Asp Pro Gln Gly Phe Phe Phe Tyr
        35                  40                  45              
Trp Thr Asp Gln Asn Lys Glu Thr Glu Leu Leu Asp Leu Ser Leu Val
    50                  55                  60                  
Lys Asp Ala Arg Cys Gly Arg His Ala Lys Ala Pro Lys Asp Pro Lys
65                  70                  75                  80  
Leu Arg Glu Leu Leu Asp Val Gly Asn Ile Gly Arg Leu Glu Gln Arg
                85                  90                  95      
Met Ile Thr Val Val Tyr Gly Pro Asp Leu Val Asn Ile Ser His Leu
            100                 105                 110         
Asn Leu Val Ala Phe Gln Glu Glu Val Ala Lys Glu Trp Thr Asn Glu
        115                 120                 125             
Val Phe Ser Leu Ala Thr Asn Leu Leu Ala Gln Asn Met Ser Arg Asp
    130                 135                 140                 
Ala Phe Leu Glu Lys Ala Tyr Thr Lys Leu Lys Leu Gln Val Thr Pro
145                 150                 155                 160 
Glu Gly Arg Ile Pro Leu Lys Asn Ile Tyr Arg Leu Phe Ser Ala Asp
                165                 170                 175     
Arg Lys Arg Val Glu Thr Ala Met Glu Ala Cys Ser Leu Pro Ser Ser
            180                 185                 190         
Arg Asn Asp Ser Ile Leu Gln Glu Asp Phe Thr Pro Glu Val Tyr Arg
        195                 200                 205             
Val Phe Phe Asn Asn Leu Cys Leu Arg Pro Glu Ile Asp Asn Ile Phe
    210                 215                 220                 
Ser Glu Phe Gly Ala Lys Ser Lys Pro Tyr Leu Thr Val Asp Gln Met
225                 230                 235                 240 
Met Asp Phe Ile Asn Leu Lys Gln Arg Asp Pro Arg Leu Asn Glu Ile
                245                 250                 255     
Leu Tyr Pro Pro Pro Lys Gln Glu Gln Val Gln Val Leu Ile Glu Lys
            260                 265                 270         
Tyr Glu Pro Asn Asn Ser Leu Ala Arg Lys Gly Gln Ile Ser Val Asp
        275                 280                 285             
Gly Phe Met Arg Tyr Leu Ser Gly Glu Glu Asn Gly Val Val Ser Thr
    290                 295                 300                 
Glu Lys Leu Asp Leu Asn Glu Asp Met Ser Arg Pro Leu Ser His Tyr
305                 310                 315                 320 
Phe Ile Asn Ser Ser His Asn Thr Tyr Leu Thr Ala Gly Gln Leu Ala
                325                 330                 335     
Gly Asn Ser Ser Val Glu Met Tyr Arg Gln Ala Leu Leu Ser Gly Cys
            340                 345                 350         
Arg Cys Val Glu Leu Asp Cys Trp Arg Gly Arg Thr Ala Glu Glu Glu
        355                 360                 365             
Pro Val Ile Thr His Gly Phe Thr Met Thr Thr Glu Ile Ser Phe Lys
    370                 375                 380                 
Glu Val Ile Lys Ala Ile Ala Glu Cys Ala Phe Lys Thr Ser Pro Phe
385                 390                 395                 400 
Pro Ile Leu Leu Ser Phe Glu Asn His Val Asp Ser Pro Lys Gln Gln
                405                 410                 415     
Ala Lys Met Ala Glu Tyr Cys Arg Leu Ile Phe Gly Asp Ala Leu Leu
            420                 425                 430         
Met Glu Pro Leu Glu Lys Tyr Pro Leu Glu Ser Gly Val Pro Leu Pro
        435                 440                 445             
Ser Pro Met Asp Leu Met Tyr Lys Ile Leu Val Lys Asn Lys Lys Lys
    450                 455                 460                 
Ser His Lys Ser Ser Glu Gly Ser Gly Lys Lys Lys Leu Ser Glu Gln
465                 470                 475                 480 
Ala Ser Asn Thr Tyr Ser Asp Ser Ser Ser Met Phe Glu Pro Ser Ser
                485                 490                 495     
Pro Gly Ala Gly Glu Ala Asp Thr Glu Ser Asp Asp Asp Asp Asp Asp
            500                 505                 510         
Asp Asp Cys Lys Lys Ser Ser Met Asp Glu Gly Thr Ala Gly Ser Glu
        515                 520                 525             
Ala Met Ala Thr Glu Glu Met Ser Asn Leu Val Asn Tyr Ile Gln Pro
    530                 535                 540                 
Val Lys Phe Glu Ser Phe Glu Ile Ser Lys Lys Arg Asn Lys Ser Phe
545                 550                 555                 560 
Glu Met Ser Ser Phe Val Glu Thr Lys Gly Leu Glu Gln Leu Thr Lys
                565                 570                 575     
Ser Pro Val Glu Phe Val Glu Tyr Asn Lys Met Gln Leu Ser Arg Ile
            580                 585                 590         
Tyr Pro Lys Gly Thr Arg Val Asp Ser Ser Asn Tyr Met Pro Gln Leu
        595                 600                 605             
Phe Trp Asn Ala Gly Cys Gln Met Val Ala Leu Asn Phe Gln Thr Met
    610                 615                 620                 
Asp Leu Ala Met Gln Ile Asn Met Gly Met Tyr Glu Tyr Asn Gly Lys
625                 630                 635                 640 
Ser Gly Tyr Arg Leu Lys Pro Glu Phe Met Arg Arg Pro Asp Lys His
                645                 650                 655     
Phe Asp Pro Phe Thr Glu Gly Ile Val Asp Gly Ile Val Ala Asn Thr
            660                 665                 670         
Leu Ser Val Lys Ile Ile Ser Gly Gln Phe Leu Ser Asp Lys Lys Val
        675                 680                 685             
Gly Thr Tyr Val Glu Val Asp Met Phe Gly Leu Pro Val Asp Thr Arg
    690                 695                 700                 
Arg Lys Ala Phe Lys Thr Lys Thr Ser Gln Gly Asn Ala Val Asn Pro
705                 710                 715                 720 
Val Trp Glu Glu Glu Pro Ile Val Phe Lys Lys Val Val Leu Pro Thr
                725                 730                 735     
Leu Ala Cys Leu Arg Ile Ala Val Tyr Glu Glu Gly Gly Lys Phe Ile
            740                 745                 750         
Gly His Arg Ile Leu Pro Val Gln Ala Ile Arg Pro Gly Tyr His Tyr
        755                 760                 765             
Ile Cys Leu Arg Asn Glu Arg Asn Gln Pro Leu Thr Leu Pro Ala Val
    770                 775                 780                 
Phe Val Tyr Ile Glu Val Lys Asp Tyr Val Pro Asp Thr Tyr Ala Asp
785                 790                 795                 800 
Val Ile Glu Ala Leu Ser Asn Pro Ile Arg Tyr Val Asn Leu Met Glu
                805                 810                 815     
Gln Arg Ala Lys Gln Leu Ala Ala Leu Thr Leu Glu Asp Glu Glu Glu
            820                 825                 830         
Val Lys Lys Glu Ala Asp Pro Gly Glu Thr Pro Ser Glu Ala Pro Ser
        835                 840                 845             
Glu Ala Arg Thr Thr Pro Ala Glu Asn Gly Val Asn His Thr Thr Thr
    850                 855                 860                 
Leu Thr Pro Lys Pro Pro Ser Gln Ala Leu His Ser Gln Pro Ala Pro
865                 870                 875                 880 
Gly Ser Val Lys Ala Pro Ala Lys Thr Glu Asp Leu Ile Gln Ser Val
                885                 890                 895     
Leu Thr Glu Val Glu Ala Gln Thr Ile Glu Glu Leu Lys Gln Gln Lys
            900                 905                 910         
Ser Phe Val Lys Leu Gln Lys Lys His Tyr Lys Glu Met Lys Asp Leu
        915                 920                 925             
Val Lys Arg His His Lys Lys Thr Thr Asp Leu Ile Lys Glu His Thr
    930                 935                 940                 
Thr Lys Tyr Asn Glu Ile Gln Asn Asp Tyr Leu Arg Arg Arg Ala Ala
945                 950                 955                 960 
Leu Glu Lys Ser Ala Lys Lys Asp Ser Lys Lys Lys Ser Glu Pro Ser
                965                 970                 975     
Ser Pro Asp His Gly Ser Ser Thr Ile Glu Gln Asp Leu Ala Ala Leu
            980                 985                 990         
Asp Ala Glu Met Thr Gln Lys Leu Ile Asp Leu Lys Asp Lys Gln Gln
        995                 1000                1005            
Gln Gln Leu Leu Asn Leu Arg Gln Glu Gln Tyr Tyr Ser Glu Lys Tyr
    1010                1015                1020                
Gln Lys Arg Glu His Ile Lys Leu Leu Ile Gln Lys Leu Thr Asp Val
1025                1030                1035                1040
Ala Glu Glu Cys Gln Asn Asn Gln Leu Lys Lys Leu Lys Glu Ile Cys
                1045                1050                1055    
Glu Lys Glu Lys Lys Glu Leu Lys Lys Lys Met Asp Lys Lys Arg Gln
            1060                1065                1070        
Glu Lys Ile Thr Glu Ala Lys Ser Lys Asp Lys Ser Gln Met Glu Glu
        1075                1080                1085            
Glu Lys Thr Glu Met Ile Arg Ser Tyr Ile Gln Glu Val Val Gln Tyr
    1090                1095                1100                
Ile Lys Arg Leu Glu Glu Ala Gln Ser Lys Arg Gln Glu Lys Leu Val
1105                1110                1115                1120
Glu Lys His Lys Glu Ile Arg Gln Gln Ile Leu Asp Glu Lys Pro Lys
                1125                1130                1135    
Leu Gln Val Glu Leu Glu Gln Glu Tyr Gln Asp Lys Phe Lys Arg Leu
            1140                1145                1150        
Pro Leu Glu Ile Leu Glu Phe Val Gln Glu Ala Met Lys Gly Lys Ile
        1155                1160                1165            
Ser Glu Asp Ser Asn His Gly Ser Ala Pro Leu Ser Leu Ser Ser Asp
    1170                1175                1180                
Pro Gly Lys Val Asn His Lys Thr Pro Ser Ser Glu Glu Leu Gly Gly
1185                1190                1195                1200
Asp Ile Pro Gly Lys Glu Phe Asp Thr Pro Leu
                1205                1210    


<210> 968
<211> 357
<212> PRT
<213> Homo sapiens

<400> 968
Met Ala Phe Ala Pro Met Gly Pro Glu Ala Ser Phe Phe Asp Val Leu
 1               5                  10                  15      
Asp Arg His Arg Glu Ser Leu Leu Ala Ala Leu Arg Arg Gly Gly Arg
            20                  25                  30          
Glu Pro Pro Thr Gly Gly Ser Arg Leu Ala Ser Phe Glu Asp Ser Val
        35                  40                  45              
Gly Leu Gln Met Val Ser His Cys Thr Thr Arg Lys Ile Lys Ser Asp
    50                  55                  60                  
Ser Pro Lys Ser Ala Gln Lys Phe Ser Leu Ile Leu Lys Ile Leu Ser
65                  70                  75                  80  
Met Ile Tyr Lys Leu Val Gln Ser Asn Thr Tyr Ala Thr Lys Arg Asp
                85                  90                  95      
Ile Tyr Tyr Thr Asp Ser Gln Leu Phe Gly Asn Gln Thr Val Val Asp
            100                 105                 110         
Asn Ile Ile Asn Asp Ile Ser Cys Met Leu Lys Val Ser Arg Arg Ser
        115                 120                 125             
Leu His Ile Leu Ser Thr Ser Lys Gly Leu Ile Ala Gly Asn Leu Arg
    130                 135                 140                 
Tyr Ile Glu Glu Asp Gly Thr Lys Val Asn Cys Thr Cys Gly Ala Thr
145                 150                 155                 160 
Ala Val Ala Val Pro Ser Asn Ile Gln Gly Ile Arg Asn Leu Val Thr
                165                 170                 175     
Asp Ala Lys Phe Val Leu Ile Val Glu Lys Asp Ala Thr Phe Gln Arg
            180                 185                 190         
Leu Leu Asp Asp Asn Phe Cys Asn Lys Leu Ser Pro Cys Ile Met Ile
        195                 200                 205             
Thr Gly Lys Gly Val Pro Asp Leu Asn Thr Arg Leu Leu Val Lys Lys
    210                 215                 220                 
Leu Trp Asp Thr Phe His Val Pro Val Phe Thr Leu Val Asp Ala Asp
225                 230                 235                 240 
Pro His Gly Ile Glu Ile Met Cys Ile Tyr Lys Tyr Gly Ser Met Ser
                245                 250                 255     
Met Ser Phe Glu Ala His His Leu Thr Val Pro Ala Ile Arg Trp Leu
            260                 265                 270         
Gly Leu Leu Pro Ser Asp Leu Lys Arg Leu Asn Val Pro Lys Asp Ser
        275                 280                 285             
Leu Ile Pro Leu Thr Lys Arg Asp Gln Met Lys Leu Asp Ser Ile Leu
    290                 295                 300                 
Arg Arg Pro Tyr Val Thr Cys Gln Pro Phe Trp Arg Lys Glu Met Glu
305                 310                 315                 320 
Ile Met Ala Asp Ser Lys Met Lys Ala Glu Ile Gln Ala Leu Thr Phe
                325                 330                 335     
Leu Ser Ser Asp Tyr Leu Ser Arg Val Tyr Leu Pro Asn Lys Leu Lys
            340                 345                 350         
Phe Gly Gly Trp Ile
        355         


<210> 969
<211> 233
<212> PRT
<213> Homo sapiens

<400> 969
Met Ala Gly Val Arg Ser Leu Arg Cys Ser Arg Gly Cys Ala Gly Gly
 1               5                  10                  15      
Cys Glu Cys Gly Asp Lys Gly Lys Cys Ser Asp Ser Ser Leu Leu Gly
            20                  25                  30          
Lys Arg Leu Ser Glu Asp Ser Ser Arg His Gln Leu Leu Gln Lys Trp
        35                  40                  45              
Ala Ser Met Trp Ser Ser Met Ser Glu Asp Ala Ser Val Ala Asp Met
    50                  55                  60                  
Glu Arg Ala Gln Leu Glu Glu Glu Ala Ala Ala Ala Glu Glu Arg Pro
65                  70                  75                  80  
Leu Val Phe Leu Cys Ser Gly Cys Arg Arg Pro Leu Gly Asp Ser Leu
                85                  90                  95      
Ser Trp Val Ala Ser Gln Glu Asp Thr Asn Cys Ile Leu Leu Arg Cys
            100                 105                 110         
Val Ser Cys Asn Val Ser Val Asp Lys Glu Gln Lys Leu Ser Lys Arg
        115                 120                 125             
Glu Lys Glu Asn Gly Cys Val Leu Glu Thr Leu Cys Cys Ala Gly Cys
    130                 135                 140                 
Ser Leu Asn Leu Gly Tyr Val Tyr Arg Cys Thr Pro Lys Asn Leu Asp
145                 150                 155                 160 
Tyr Lys Arg Asp Leu Phe Cys Leu Ser Val Glu Ala Ile Glu Ser Tyr
                165                 170                 175     
Val Leu Gly Ser Ser Glu Lys Gln Ile Val Ser Glu Asp Lys Glu Leu
            180                 185                 190         
Phe Asn Leu Glu Ser Arg Val Glu Ile Glu Lys Ser Leu Thr Gln Met
        195                 200                 205             
Glu Asp Val Leu Lys Ala Leu Gln Met Lys Leu Trp Glu Ala Glu Ser
    210                 215                 220                 
Lys Leu Ser Phe Ala Thr Cys Lys Ser
225                 230             


<210> 970
<211> 582
<212> PRT
<213> Homo sapiens

<400> 970
Met Met Lys Leu Arg His Lys Asn Lys Lys Pro Gly Glu Gly Ser Lys
 1               5                  10                  15      
Gly His Lys Lys Ile Ser Trp Pro Tyr Pro Gln Pro Ala Lys Gln Asn
            20                  25                  30          
Gly Lys Lys Ala Thr Ser Lys Val Pro Ser Ala Pro His Phe Val His
        35                  40                  45              
Pro Asn Asp His Ala Asn Arg Glu Ala Glu Leu Lys Lys Lys Trp Val
    50                  55                  60                  
Glu Glu Met Arg Glu Lys Gln Gln Ala Ala Arg Glu Gln Glu Arg Gln
65                  70                  75                  80  
Lys Arg Arg Thr Ile Glu Ser Tyr Cys Gln Asp Val Leu Arg Arg Gln
                85                  90                  95      
Glu Glu Phe Glu His Lys Glu Glu Val Leu Gln Glu Leu Asn Met Phe
            100                 105                 110         
Pro Gln Leu Asp Asp Glu Ala Thr Arg Lys Ala Tyr Tyr Lys Glu Phe
        115                 120                 125             
Arg Lys Val Val Glu Tyr Ser Asp Val Ile Leu Glu Val Leu Asp Ala
    130                 135                 140                 
Arg Asp Pro Leu Gly Cys Arg Cys Phe Gln Met Glu Glu Ala Val Leu
145                 150                 155                 160 
Arg Ala Gln Gly Asn Lys Lys Leu Val Leu Val Leu Asn Lys Ile Asp
                165                 170                 175     
Leu Val Pro Lys Glu Val Val Glu Lys Trp Leu Asp Tyr Leu Arg Asn
            180                 185                 190         
Glu Leu Pro Thr Val Ala Phe Lys Ala Ser Thr Gln His Gln Val Lys
        195                 200                 205             
Asn Leu Asn Arg Cys Ser Val Pro Val Asp Gln Ala Ser Glu Ser Leu
    210                 215                 220                 
Leu Lys Ser Lys Ala Cys Phe Gly Ala Glu Asn Leu Met Arg Val Leu
225                 230                 235                 240 
Gly Asn Tyr Cys Arg Leu Gly Glu Val Arg Thr His Ile Arg Val Gly
                245                 250                 255     
Val Val Gly Leu Pro Asn Val Gly Lys Ser Ser Leu Ile Asn Ser Leu
            260                 265                 270         
Lys Arg Ser Arg Ala Cys Ser Val Gly Ala Val Pro Gly Ile Thr Lys
        275                 280                 285             
Phe Met Gln Glu Val Tyr Leu Asp Lys Phe Ile Arg Leu Leu Asp Ala
    290                 295                 300                 
Pro Gly Ile Val Pro Gly Pro Asn Ser Glu Val Gly Thr Ile Leu Arg
305                 310                 315                 320 
Asn Cys Val His Val Gln Lys Leu Ala Asp Pro Val Thr Pro Val Glu
                325                 330                 335     
Thr Ile Leu Gln Arg Cys Asn Leu Glu Glu Ile Ser Asn Tyr Tyr Gly
            340                 345                 350         
Val Ser Gly Phe Gln Thr Thr Glu His Phe Leu Thr Ala Val Ala His
        355                 360                 365             
Arg Leu Gly Lys Lys Lys Lys Gly Gly Leu Tyr Ser Gln Glu Gln Ala
    370                 375                 380                 
Ala Lys Ala Val Leu Ala Asp Trp Val Ser Gly Lys Ile Ser Phe Tyr
385                 390                 395                 400 
Ile Pro Pro Pro Ala Thr His Thr Leu Pro Thr His Leu Ser Ala Glu
                405                 410                 415     
Ile Val Lys Glu Met Thr Glu Val Phe Asp Ile Glu Asp Thr Glu Gln
            420                 425                 430         
Ala Asn Glu Asp Thr Met Glu Cys Leu Ala Thr Gly Glu Ser Asp Glu
        435                 440                 445             
Leu Leu Gly Asp Thr Asp Pro Leu Glu Met Glu Ile Lys Leu Leu His
    450                 455                 460                 
Ser Pro Met Thr Lys Ile Ala Asp Ala Ile Glu Asn Lys Thr Thr Val
465                 470                 475                 480 
Tyr Lys Ile Gly Asp Leu Thr Gly Tyr Cys Thr Asn Pro Asn Arg His
                485                 490                 495     
Gln Met Gly Trp Ala Lys Arg Asn Val Asp His Arg Pro Lys Ser Asn
            500                 505                 510         
Ser Met Val Asp Val Cys Ser Val Asp Arg Arg Ser Val Leu Gln Arg
        515                 520                 525             
Ile Met Glu Thr Asp Pro Leu Gln Gln Gly Gln Ala Leu Ala Ser Ala
    530                 535                 540                 
Leu Lys Asn Lys Lys Lys Met Gln Lys Arg Ala Asp Lys Ile Ala Ser
545                 550                 555                 560 
Lys Leu Ser Asp Ser Met Met Ser Ala Leu Asp Leu Ser Gly Asn Ala
                565                 570                 575     
Asp Asp Gly Val Gly Asp
            580         


<210> 971
<211> 582
<212> PRT
<213> Homo sapiens

<400> 971
Met Met Lys Leu Arg His Lys Asn Lys Lys Pro Gly Glu Gly Ser Lys
 1               5                  10                  15      
Gly His Lys Lys Ile Ser Trp Pro Tyr Pro Gln Pro Ala Lys Gln Asn
            20                  25                  30          
Gly Lys Lys Ala Thr Ser Lys Val Pro Ser Ala Pro His Phe Val His
        35                  40                  45              
Pro Asn Asp His Ala Asn Arg Glu Ala Glu Leu Lys Lys Lys Trp Val
    50                  55                  60                  
Glu Glu Met Arg Glu Lys Gln Gln Ala Ala Arg Glu Gln Glu Arg Gln
65                  70                  75                  80  
Lys Arg Arg Thr Ile Glu Ser Tyr Cys Gln Asp Val Leu Arg Arg Gln
                85                  90                  95      
Glu Glu Phe Glu His Lys Glu Glu Val Leu Gln Glu Leu Asn Met Phe
            100                 105                 110         
Pro Gln Leu Asp Asp Glu Ala Thr Arg Lys Ala Tyr Tyr Lys Glu Phe
        115                 120                 125             
Arg Lys Val Val Glu Tyr Ser Asp Val Ile Leu Glu Val Leu Asp Ala
    130                 135                 140                 
Arg Asp Pro Leu Gly Cys Arg Cys Phe Gln Met Glu Glu Ala Val Leu
145                 150                 155                 160 
Arg Ala Gln Gly Asn Lys Lys Leu Val Leu Val Leu Asn Lys Ile Asp
                165                 170                 175     
Leu Val Pro Lys Glu Val Val Glu Lys Trp Leu Asp Tyr Leu Arg Asn
            180                 185                 190         
Glu Leu Pro Thr Val Ala Phe Lys Ala Ser Thr Gln His Gln Val Lys
        195                 200                 205             
Asn Leu Asn Arg Cys Ser Val Pro Val Asp Gln Ala Ser Glu Ser Leu
    210                 215                 220                 
Leu Lys Ser Lys Ala Cys Phe Gly Ala Glu Asn Leu Met Arg Val Leu
225                 230                 235                 240 
Gly Asn Tyr Cys Arg Leu Gly Glu Val Arg Thr His Ile Arg Val Gly
                245                 250                 255     
Val Val Gly Leu Pro Asn Val Gly Lys Ser Ser Leu Ile Asn Ser Leu
            260                 265                 270         
Lys Arg Ser Arg Ala Cys Ser Val Gly Ala Val Pro Gly Ile Thr Lys
        275                 280                 285             
Phe Met Gln Glu Val Tyr Leu Asp Lys Phe Ile Arg Leu Leu Asp Ala
    290                 295                 300                 
Pro Gly Ile Val Pro Gly Pro Asn Ser Glu Val Gly Thr Ile Leu Arg
305                 310                 315                 320 
Asn Cys Val His Val Gln Lys Leu Ala Asp Pro Val Thr Pro Val Glu
                325                 330                 335     
Thr Ile Leu Gln Arg Cys Asn Leu Glu Glu Ile Ser Asn Tyr Tyr Gly
            340                 345                 350         
Val Ser Gly Phe Gln Thr Thr Glu His Phe Leu Thr Ala Val Ala His
        355                 360                 365             
Arg Leu Gly Lys Lys Lys Lys Gly Gly Leu Tyr Ser Gln Glu Gln Ala
    370                 375                 380                 
Ala Lys Ala Val Leu Ala Asp Trp Val Ser Gly Lys Ile Ser Phe Tyr
385                 390                 395                 400 
Ile Pro Pro Pro Ala Thr His Thr Leu Pro Thr His Leu Ser Ala Glu
                405                 410                 415     
Ile Val Lys Glu Met Thr Glu Val Phe Asp Ile Glu Asp Thr Glu Gln
            420                 425                 430         
Ala Asn Glu Asp Thr Met Glu Cys Leu Ala Thr Gly Glu Ser Asp Glu
        435                 440                 445             
Leu Leu Gly Asp Thr Asp Pro Leu Glu Met Glu Ile Lys Leu Leu His
    450                 455                 460                 
Ser Pro Met Thr Lys Ile Ala Asp Ala Ile Glu Asn Lys Thr Thr Val
465                 470                 475                 480 
Tyr Lys Ile Gly Asp Leu Thr Gly Tyr Cys Thr Asn Pro Asn Arg His
                485                 490                 495     
Gln Met Gly Trp Ala Lys Arg Asn Val Asp His Arg Pro Lys Ser Asn
            500                 505                 510         
Ser Met Val Asp Val Cys Ser Val Asp Arg Arg Ser Val Leu Gln Arg
        515                 520                 525             
Ile Met Glu Thr Asp Pro Leu Gln Gln Gly Gln Ala Leu Ala Ser Ala
    530                 535                 540                 
Leu Lys Asn Lys Lys Lys Met Gln Lys Arg Ala Asp Lys Ile Ala Ser
545                 550                 555                 560 
Lys Leu Ser Asp Ser Met Met Ser Ala Leu Asp Leu Ser Gly Asn Ala
                565                 570                 575     
Asp Asp Gly Val Gly Asp
            580         


<210> 972
<211> 428
<212> PRT
<213> Homo sapiens

<400> 972
Met Arg Arg Thr Lys Glu Tyr Val Ser Asn Asp Ala Ala Gln Ser Asp
 1               5                  10                  15      
Asp Glu Glu Lys Leu Gln Ser Gln Pro Thr Asp Thr Asp Gly Gly Arg
            20                  25                  30          
Leu Lys Gln Lys Thr Thr Gln Leu Lys Lys Phe Leu Gly Lys Ser Val
        35                  40                  45              
Lys Arg Ala Lys His Leu Ala Glu Glu Tyr Gly Glu Arg Ala Ile Asn
    50                  55                  60                  
Lys Val Lys Ser Val Arg Asp Glu Val Phe His Thr Asp Gln Asp Asp
65                  70                  75                  80  
Pro Ser Ser Ser Asp Asp Glu Gly Met Pro Tyr Thr Arg Pro Val Lys
                85                  90                  95      
Phe Lys Ala Ala His Gly Phe Lys Gly Pro Tyr Asp Phe Asp Gln Ile
            100                 105                 110         
Lys Val Val Gln Asp Leu Ser Gly Glu His Met Gly Ala Val Trp Thr
        115                 120                 125             
Met Lys Phe Ser His Cys Gly Arg Leu Leu Ala Ser Ala Gly Gln Asp
    130                 135                 140                 
Asn Val Val Arg Ile Trp Ala Leu Lys Asn Ala Phe Asp Tyr Phe Asn
145                 150                 155                 160 
Asn Met Arg Met Lys Tyr Asn Thr Glu Gly Arg Val Ser Pro Ser Pro
                165                 170                 175     
Ser Gln Glu Ser Leu Ser Ser Ser Lys Ser Asp Thr Asp Thr Gly Val
            180                 185                 190         
Cys Ser Gly Thr Asp Glu Asp Pro Asp Asp Lys Asn Ala Pro Phe Arg
        195                 200                 205             
Gln Arg Pro Phe Cys Lys Tyr Lys Gly His Thr Ala Asp Leu Leu Asp
    210                 215                 220                 
Leu Ser Trp Ser Lys Asn Tyr Phe Leu Leu Ser Ser Ser Met Asp Lys
225                 230                 235                 240 
Thr Val Arg Leu Trp His Ile Ser Arg Arg Glu Cys Leu Cys Cys Phe
                245                 250                 255     
Gln His Ile Asp Thr Ala Ile Ala Phe His Pro Arg Asp Asp Arg Tyr
            260                 265                 270         
Phe Leu Ser Gly Ser Leu Asp Gly Lys Leu Arg Leu Trp Asn Ile Pro
        275                 280                 285             
Asp Lys Lys Val Ala Leu Trp Asn Glu Val Asp Gly Gln Thr Lys Leu
    290                 295                 300                 
Ile Thr Ala Ala Asn Phe Cys Gln Asn Gly Lys Tyr Ala Val Ile Gly
305                 310                 315                 320 
Thr Tyr Asp Gly Arg Cys Ile Phe Tyr Asp Thr Glu His Leu Lys Tyr
                325                 330                 335     
His Thr Gln Ile His Val Arg Ser Thr Arg Gly Arg Asn Lys Val Gly
            340                 345                 350         
Arg Lys Ile Thr Gly Ile Glu Pro Leu Pro Gly Glu Asn Lys Ile Leu
        355                 360                 365             
Val Thr Ser Asn Asp Ser Arg Ile Arg Leu Tyr Asp Leu Arg Asp Leu
    370                 375                 380                 
Ser Leu Ser Met Lys Tyr Lys Gly Tyr Val Asn Ser Ser Ser Gln Ile
385                 390                 395                 400 
Lys Gln Val Ser Ala Met Ile Leu Leu Thr Ser Leu Val Val Gln Lys
                405                 410                 415     
Ile Ser Met Phe Ile Ser Gly Val Pro Thr Met Thr
            420                 425             


<210> 973
<211> 643
<212> PRT
<213> Homo sapiens

<400> 973
Met Cys Gly Ile Cys Cys Ser Val Asn Phe Ser Ala Glu His Phe Ser
 1               5                  10                  15      
Gln Asp Leu Lys Glu Asp Leu Leu Tyr Asn Leu Lys Gln Arg Gly Pro
            20                  25                  30          
Asn Ser Ser Lys Gln Leu Leu Lys Ser Asp Val Asn Tyr Gln Cys Leu
        35                  40                  45              
Phe Ser Ala His Val Leu His Leu Arg Gly Val Leu Thr Thr Gln Pro
    50                  55                  60                  
Val Glu Asp Glu Arg Gly Asn Val Phe Leu Trp Asn Gly Glu Ile Phe
65                  70                  75                  80  
Ser Gly Ile Lys Val Glu Ala Glu Glu Asn Asp Thr Gln Ile Leu Phe
                85                  90                  95      
Asn Tyr Leu Ser Ser Cys Lys Asn Glu Ser Glu Ile Leu Ser Leu Phe
            100                 105                 110         
Ser Glu Val Gln Gly Pro Trp Ser Phe Ile Tyr Tyr Gln Ala Ser Ser
        115                 120                 125             
His Tyr Leu Trp Phe Gly Arg Asp Phe Phe Gly Arg Arg Ser Leu Leu
    130                 135                 140                 
Trp His Phe Ser Asn Leu Gly Lys Ser Phe Cys Leu Ser Ser Val Gly
145                 150                 155                 160 
Thr Gln Thr Ser Gly Leu Ala Asn Gln Trp Gln Glu Val Pro Ala Ser
                165                 170                 175     
Gly Leu Phe Arg Ile Asp Leu Lys Ser Thr Val Ile Ser Arg Cys Ile
            180                 185                 190         
Ile Leu Gln Leu Tyr Pro Trp Lys Tyr Ile Ser Arg Glu Asn Ile Ile
        195                 200                 205             
Glu Glu Asn Val Asn Ser Leu Ser Gln Ile Ser Ala Asp Leu Pro Ala
    210                 215                 220                 
Phe Val Ser Val Val Ala Asn Glu Ala Lys Leu Tyr Leu Glu Lys Pro
225                 230                 235                 240 
Val Val Pro Leu Asn Met Met Leu Pro Gln Ala Ala Leu Glu Thr His
                245                 250                 255     
Cys Ser Asn Ile Ser Asn Val Pro Pro Thr Arg Glu Ile Leu Gln Val
            260                 265                 270         
Phe Leu Thr Asp Val His Met Lys Glu Val Ile Gln Gln Phe Ile Asp
        275                 280                 285             
Val Leu Ser Val Ala Val Lys Lys Arg Val Leu Cys Leu Pro Arg Asp
    290                 295                 300                 
Glu Asn Leu Thr Ala Asn Glu Val Leu Lys Thr Cys Asp Arg Lys Ala
305                 310                 315                 320 
Asn Val Ala Ile Leu Phe Ser Gly Gly Ile Asp Ser Met Val Ile Ala
                325                 330                 335     
Thr Leu Ala Asp Arg His Ile Pro Leu Asp Glu Pro Ile Asp Leu Leu
            340                 345                 350         
Asn Val Ala Phe Ile Ala Glu Glu Lys Thr Met Pro Thr Thr Phe Asn
        355                 360                 365             
Arg Glu Gly Asn Lys Gln Lys Asn Lys Cys Glu Ile Pro Ser Glu Glu
    370                 375                 380                 
Phe Ser Lys Asp Val Ala Ala Ala Ala Ala Asp Ser Pro Asn Lys His
385                 390                 395                 400 
Val Ser Val Pro Asp Arg Ile Thr Gly Arg Ala Gly Leu Lys Glu Leu
                405                 410                 415     
Gln Ala Val Ser Pro Ser Arg Ile Trp Asn Phe Val Glu Ile Asn Val
            420                 425                 430         
Ser Met Glu Glu Leu Gln Lys Leu Arg Arg Thr Arg Ile Cys His Leu
        435                 440                 445             
Ile Arg Pro Leu Asp Thr Val Leu Asp Asp Ser Ile Gly Cys Ala Val
    450                 455                 460                 
Trp Phe Ala Ser Arg Gly Ile Gly Trp Leu Val Ala Gln Glu Gly Val
465                 470                 475                 480 
Lys Ser Tyr Gln Ser Asn Ala Lys Val Val Leu Thr Gly Ile Gly Ala
                485                 490                 495     
Asp Glu Gln Leu Ala Gly Tyr Ser Arg His Arg Val Arg Phe Gln Ser
            500                 505                 510         
His Gly Leu Glu Gly Leu Asn Lys Glu Ile Met Met Glu Leu Gly Arg
        515                 520                 525             
Ile Ser Ser Arg Asn Leu Gly Arg Asp Asp Arg Val Ile Gly Asp His
    530                 535                 540                 
Gly Lys Glu Ala Arg Phe Pro Phe Leu Asp Glu Asn Val Val Ser Phe
545                 550                 555                 560 
Leu Asn Ser Leu Pro Ile Trp Glu Lys Ala Asn Leu Thr Leu Pro Arg
                565                 570                 575     
Gly Ile Gly Glu Lys Leu Leu Leu Arg Leu Ala Ala Val Glu Leu Gly
            580                 585                 590         
Leu Thr Ala Ser Ala Leu Leu Pro Lys Arg Ala Met Gln Phe Gly Ser
        595                 600                 605             
Arg Ile Ala Lys Met Glu Lys Ile Asn Glu Lys Ala Ser Asp Lys Cys
    610                 615                 620                 
Gly Arg Leu Gln Ile Met Ser Leu Glu Asn Leu Ser Ile Glu Lys Glu
625                 630                 635                 640 
Thr Lys Leu
            


<210> 974
<211> 217
<212> PRT
<213> Homo sapiens

<400> 974
Met Ser Phe Arg Gly Gly Gly Arg Gly Gly Phe Asn Arg Gly Gly Gly
 1               5                  10                  15      
Gly Gly Gly Phe Asn Arg Gly Gly Ser Ser Asn His Phe Arg Gly Gly
            20                  25                  30          
Gly Gly Gly Gly Gly Gly Gly Asn Phe Arg Gly Gly Gly Arg Gly Gly
        35                  40                  45              
Phe Gly Arg Gly Gly Gly Arg Gly Gly Phe Asn Lys Gly Gln Asp Gln
    50                  55                  60                  
Gly Pro Pro Glu Arg Val Val Leu Leu Gly Glu Phe Leu His Pro Cys
65                  70                  75                  80  
Glu Asp Asp Ile Val Cys Lys Cys Thr Thr Asp Glu Asn Lys Val Pro
                85                  90                  95      
Tyr Phe Asn Ala Pro Val Tyr Leu Glu Asn Lys Glu Gln Ile Gly Lys
            100                 105                 110         
Val Asp Glu Ile Phe Gly Gln Leu Arg Asp Phe Tyr Phe Ser Val Lys
        115                 120                 125             
Leu Ser Glu Asn Met Lys Ala Ser Ser Phe Lys Lys Leu Gln Lys Phe
    130                 135                 140                 
Tyr Ile Asp Pro Tyr Lys Leu Leu Pro Leu Gln Arg Phe Leu Pro Arg
145                 150                 155                 160 
Pro Pro Gly Glu Lys Gly Pro Pro Arg Gly Gly Gly Arg Gly Gly Arg
                165                 170                 175     
Gly Gly Gly Arg Gly Gly Gly Gly Arg Gly Gly Gly Arg Gly Gly Gly
            180                 185                 190         
Phe Arg Gly Gly Arg Gly Gly Gly Gly Gly Gly Phe Arg Gly Gly Arg
        195                 200                 205             
Gly Gly Gly Phe Arg Gly Arg Gly His
    210                 215         


<210> 975
<211> 373
<212> PRT
<213> Homo sapiens

<400> 975
Met Pro Asp Glu Leu Thr Glu Pro Gly Arg Ala Thr Pro Ala Arg Ala
 1               5                  10                  15      
Ser Ser Phe Leu Ile Glu Asn Leu Leu Ala Ala Glu Ala Lys Gly Ala
            20                  25                  30          
Gly Arg Asp Pro Gly Arg Arg Gln Pro Gly Gly Arg Gly Gly Gly Arg
        35                  40                  45              
Arg Arg Pro Arg Arg Arg Gly Arg Arg Ala Gly Arg Arg Arg Arg Leu
    50                  55                  60                  
Gln Arg Arg Arg Gln Leu Leu Ala Gly Thr Gly Pro Gly Gly Glu Ala
65                  70                  75                  80  
Arg Ala Val Pro Ala Arg Ala Gly Ala Leu Gly Leu Gly Pro Arg Pro
                85                  90                  95      
Pro Pro Gly Pro Gly Pro Pro Phe Ala Leu Gly Cys Gly Gly Ala Gly
            100                 105                 110         
Arg Trp Tyr Pro Arg Ala His Gly Gly Tyr Gly Gly Gly Leu Ser Pro
        115                 120                 125             
Asp Thr Ser Asp Arg Asp Ser Pro Glu Thr Gly Glu Glu Met Gly Arg
    130                 135                 140                 
Ala Glu Gly Ala Trp Pro Arg Gly Pro Gly Arg Ser Gly Ala Ala Gly
145                 150                 155                 160 
Gly Ser Gly Ala Gly Gly Ala Trp Pro Gly Gly Arg His Gly Gly Gly
                165                 170                 175     
Ser Glu Leu Ala Glu Val Pro Ala Ala Ala Gly Glu Thr Arg Gly Gly
            180                 185                 190         
Val Gly Val Gly Gly Gly Arg Lys Lys Lys Thr Arg Thr Val Phe Ser
        195                 200                 205             
Arg Ser Gln Val Phe Gln Leu Glu Ser Thr Phe Asp Leu Lys Arg Tyr
    210                 215                 220                 
Leu Ser Thr Ala Glu Arg Ala Gly Leu Ala Ala Ser Leu Gln Leu Thr
225                 230                 235                 240 
Glu Thr Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Asn Lys Trp Lys
                245                 250                 255     
Arg His Val Ala Ala Glu Leu Glu Ala Ala Ser Leu Ser Pro Pro Gly
            260                 265                 270         
Ala His Ala Trp Ser Ala Cys Arg Cys Ser Thr Thr Lys Ala Pro Arg
        275                 280                 285             
Pro Arg Pro Pro Leu Gly Pro Arg Pro Pro Cys Pro Ser Arg Trp Pro
    290                 295                 300                 
Ala Gly Pro Arg Arg Pro His Arg Cys Ser Ala Ser Pro Gly Pro Ser
305                 310                 315                 320 
Pro Thr Arg Trp Pro Pro Ser Arg Pro Pro Pro Pro Cys Pro Phe Cys
                325                 330                 335     
Gly Arg Arg Cys Leu Ala Trp Cys Glu Pro Arg Leu Pro Gly Pro Leu
            340                 345                 350         
Pro Thr Thr Leu Trp Thr Cys Val Asp Ala Arg Ser Ala Ala Gly Ala
        355                 360                 365             
Gly Leu Arg Gly Arg
    370             


<210> 976
<211> 45
<212> PRT
<213> Homo sapiens

<400> 976
Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro Ala Ser Tyr
 1               5                  10                  15      
Asn Pro Met Val Leu Ile Gln Lys Ala Asp Thr Gly Val Ser Leu Gln
            20                  25                  30          
Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile
        35                  40                  45  


<210> 977
<211> 226
<212> PRT
<213> Homo sapiens

<400> 977
Leu Ser Ala Leu Ser Leu Ala Lys Asp Ser Leu Val Gly Gly Ile Thr
 1               5                  10                  15      
Asn Pro Gly Glu Val Phe Cys Ser Val Pro Gly Arg Leu Ser Leu Leu
            20                  25                  30          
Ser Ser Thr Ser Lys Tyr Lys Val Thr Val Gly Glu Val Gln Arg Arg
        35                  40                  45              
Leu Ser Pro Pro Glu Cys Leu Asn Ala Ser Leu Leu Gly Gly Val Leu
    50                  55                  60                  
Arg Arg Ala Lys Ser Lys Asn Gly Gly Arg Cys Leu Arg Glu Arg Leu
65                  70                  75                  80  
Glu Lys Ile Gly Leu Asn Leu Pro Ala Gly Arg Arg Lys Ala Ala Asn
                85                  90                  95      
Val Thr Leu Leu Thr Ser Leu Val Glu Gly Glu Ala Val His Leu Ala
            100                 105                 110         
Arg Asp Phe Gly Tyr Val Cys Glu Thr Glu Phe Pro Ala Lys Ala Ala
        115                 120                 125             
Ala Glu Tyr Leu Cys Arg Gln His Ala Asp Pro Gly Glu Leu His Ser
    130                 135                 140                 
Arg Lys Ser Met Leu Leu Ala Ala Lys Gln Ile Cys Lys Glu Phe Ala
145                 150                 155                 160 
Asp Leu Met Ala Gln Asp Arg Ser Pro Leu Gly Asn Ser Arg Pro Ala
                165                 170                 175     
Leu Ile Leu Glu Pro Gly Val Gln Ser Cys Leu Thr His Phe Ser Leu
            180                 185                 190         
Ile Thr His Gly Phe Gly Gly Pro Ala Ile Cys Ala Ala Leu Thr Ala
        195                 200                 205             
Phe Gln Asn Tyr Leu Leu Glu Ser Leu Lys Gly Leu Asp Lys Met Phe
    210                 215                 220                 
Leu Ser
225     


<210> 978
<211> 79
<212> PRT
<213> Homo sapiens

<400> 978
Met His Pro Asp Leu Ser Pro His Leu His Thr Glu Glu Cys Asn Val
 1               5                  10                  15      
Leu Ile Asn Leu Leu Lys Glu Cys His Lys Asn His Asn Ile Leu Lys
            20                  25                  30          
Phe Phe Gly Tyr Cys Asn Asp Val Asp Arg Glu Leu Arg Lys Cys Leu
        35                  40                  45              
Lys Asn Glu Tyr Val Glu Asn Arg Thr Lys Ser Arg Glu His Gly Ile
    50                  55                  60                  
Ala Met Arg Lys Lys Leu Phe Asn Pro Pro Glu Glu Ser Glu Lys
65                  70                  75                  


<210> 979
<211> 360
<212> PRT
<213> Homo sapiens

<400> 979
Met Ala Pro Leu Gly Thr Thr Val Leu Leu Trp Ser Leu Leu Arg Ser
 1               5                  10                  15      
Ser Pro Gly Val Glu Arg Val Cys Phe Arg Ala Arg Ile Gln Pro Trp
            20                  25                  30          
His Gly Gly Leu Leu Gln Pro Leu Pro Cys Ser Phe Glu Met Gly Leu
        35                  40                  45              
Pro Arg Arg Arg Phe Ser Ser Glu Ala Ala Glu Ser Gly Ser Pro Glu
    50                  55                  60                  
Thr Lys Lys Pro Thr Phe Met Asp Glu Glu Val Gln Ser Ile Leu Thr
65                  70                  75                  80  
Lys Met Thr Gly Leu Asn Leu Gln Lys Thr Phe Lys Pro Ala Ile Gln
                85                  90                  95      
Glu Leu Lys Pro Pro Thr Tyr Lys Leu Met Thr Gln Ala Gln Leu Glu
            100                 105                 110         
Glu Ala Thr Arg Gln Ala Val Glu Ala Ala Lys Val Arg Leu Lys Met
        115                 120                 125             
Pro Pro Val Leu Glu Glu Arg Val Pro Ile Asn Asp Val Leu Ala Glu
    130                 135                 140                 
Asp Lys Ile Leu Glu Gly Thr Glu Thr Thr Lys Tyr Val Phe Thr Asp
145                 150                 155                 160 
Ile Ser Tyr Ser Ile Pro His Arg Glu Arg Phe Ile Val Val Arg Glu
                165                 170                 175     
Pro Ser Gly Thr Leu Arg Lys Ala Ser Trp Glu Glu Arg Asp Arg Met
            180                 185                 190         
Ile Gln Val Tyr Phe Pro Lys Glu Gly Arg Lys Ile Leu Thr Pro Ile
        195                 200                 205             
Ile Phe Lys Glu Glu Asn Leu Arg Thr Met Tyr Ser Gln Asp Arg His
    210                 215                 220                 
Val Asp Val Leu Asn Leu Cys Phe Ala Gln Phe Glu Pro Asp Ser Thr
225                 230                 235                 240 
Glu Tyr Ile Lys Val His His Lys Thr Tyr Glu Asp Ile Asp Lys Arg
                245                 250                 255     
Gly Lys Tyr Asp Leu Leu Arg Ser Thr Arg Tyr Phe Gly Gly Met Val
            260                 265                 270         
Trp Tyr Phe Val Asn Asn Lys Lys Ile Asp Gly Leu Leu Ile Asp Gln
        275                 280                 285             
Ile Gln Arg Asp Leu Ile Asp Asp Ala Thr Asn Leu Val Gln Leu Tyr
    290                 295                 300                 
His Val Leu His Pro Asp Gly Gln Ser Ala Gln Gly Ala Lys Asp Gln
305                 310                 315                 320 
Ala Ala Glu Gly Ile Asn Leu Ile Lys Val Phe Ala Lys Thr Glu Ala
                325                 330                 335     
Gln Lys Gly Ala Tyr Ile Glu Leu Thr Leu Gln Thr Tyr Gln Glu Ala
            340                 345                 350         
Leu Ser Arg His Ser Ala Ala Ser
        355                 360 


<210> 980
<211> 1555
<212> PRT
<213> Homo sapiens

<400> 980
Met Gly Cys Lys Gly Asp Ala Ser Gly Ala Cys Ala Ala Gly Ala Leu
 1               5                  10                  15      
Pro Val Thr Gly Val Cys Tyr Lys Met Gly Val Leu Val Val Leu Thr
            20                  25                  30          
Val Leu Trp Leu Phe Ser Ser Val Lys Ala Asp Ser Lys Ala Ile Thr
        35                  40                  45              
Thr Ser Leu Thr Thr Lys Trp Phe Ser Thr Pro Leu Leu Leu Glu Ala
    50                  55                  60                  
Ser Glu Phe Leu Ala Glu Asp Ser Gln Glu Lys Phe Trp Asn Phe Val
65                  70                  75                  80  
Glu Ala Ser Gln Asn Ile Gly Ser Ser Asp His Asp Gly Thr Asp Tyr
                85                  90                  95      
Ser Tyr Tyr His Ala Ile Leu Glu Ala Ala Phe Gln Phe Leu Ser Pro
            100                 105                 110         
Leu Gln Gln Asn Leu Phe Lys Phe Cys Leu Ser Leu Arg Ser Tyr Ser
        115                 120                 125             
Ala Thr Ile Gln Ala Phe Gln Gln Ile Ala Ala Asp Glu Pro Pro Pro
    130                 135                 140                 
Glu Gly Cys Asn Ser Phe Phe Ser Val His Gly Lys Lys Thr Cys Glu
145                 150                 155                 160 
Ser Asp Thr Leu Glu Ala Leu Leu Leu Thr Ala Ser Glu Arg Pro Lys
                165                 170                 175     
Pro Leu Leu Phe Lys Gly Asp His Arg Tyr Pro Ser Ser Asn Pro Glu
            180                 185                 190         
Ser Pro Val Val Ile Phe Tyr Ser Glu Ile Gly Ser Glu Glu Phe Ser
        195                 200                 205             
Asn Phe His Arg Gln Leu Ile Ser Lys Ser Asn Ala Gly Lys Ile Asn
    210                 215                 220                 
Tyr Val Phe Arg His Tyr Ile Phe Asn Pro Arg Lys Glu Pro Val Tyr
225                 230                 235                 240 
Leu Ser Gly Tyr Gly Val Glu Leu Ala Ile Lys Ser Thr Glu Tyr Lys
                245                 250                 255     
Ala Lys Asp Asp Thr Gln Val Lys Gly Thr Glu Val Asn Thr Thr Val
            260                 265                 270         
Ile Gly Glu Asn Asp Pro Ile Asp Glu Val Gln Gly Phe Leu Phe Gly
        275                 280                 285             
Lys Leu Arg Asp Leu His Pro Asp Leu Glu Gly Gln Leu Lys Glu Leu
    290                 295                 300                 
Arg Lys His Leu Val Glu Ser Thr Asn Glu Met Ala Pro Leu Lys Val
305                 310                 315                 320 
Trp Gln Leu Gln Asp Leu Ser Phe Gln Thr Ala Ala Arg Ile Leu Ala
                325                 330                 335     
Ser Pro Val Glu Leu Ala Leu Val Val Met Lys Asp Leu Ser Gln Asn
            340                 345                 350         
Phe Pro Thr Lys Ala Arg Ala Ile Thr Lys Thr Ala Val Ser Ser Glu
        355                 360                 365             
Leu Arg Thr Glu Val Glu Glu Asn Gln Lys Tyr Phe Lys Gly Thr Leu
    370                 375                 380                 
Gly Leu Gln Pro Gly Asp Ser Ala Leu Phe Ile Asn Gly Leu His Met
385                 390                 395                 400 
Asp Leu Asp Thr Gln Asp Ile Phe Ser Leu Phe Asp Val Leu Arg Asn
                405                 410                 415     
Glu Ala Arg Val Met Glu Gly Leu His Arg Leu Gly Ile Glu Gly Leu
            420                 425                 430         
Ser Leu His Asn Val Leu Lys Leu Asn Ile Gln Pro Ser Glu Ala Asp
        435                 440                 445             
Tyr Ala Val Asp Ile Arg Ser Pro Ala Ile Ser Trp Val Asn Asn Leu
    450                 455                 460                 
Glu Val Asp Ser Arg Tyr Asn Ser Trp Pro Ser Ser Leu Gln Glu Leu
465                 470                 475                 480 
Leu Arg Pro Thr Phe Pro Gly Val Ile Arg Gln Ile Arg Lys Asn Leu
                485                 490                 495     
His Asn Met Val Phe Ile Val Asp Pro Ala His Glu Thr Thr Ala Glu
            500                 505                 510         
Leu Met Asn Thr Ala Glu Met Phe Leu Ser Asn His Ile Pro Leu Arg
        515                 520                 525             
Ile Gly Phe Ile Phe Val Val Asn Asp Ser Glu Asp Val Asp Gly Met
    530                 535                 540                 
Gln Asp Ala Gly Val Ala Val Leu Arg Ala Tyr Asn Tyr Val Ala Gln
545                 550                 555                 560 
Glu Val Asp Asp Tyr His Ala Phe Gln Thr Leu Thr His Ile Tyr Asn
                565                 570                 575     
Lys Val Arg Thr Gly Glu Lys Val Lys Val Glu His Val Val Ser Val
            580                 585                 590         
Leu Glu Lys Lys Tyr Pro Tyr Val Glu Val Asn Ser Ile Leu Gly Ile
        595                 600                 605             
Asp Ser Ala Tyr Asp Arg Asn Arg Lys Glu Ala Arg Gly Tyr Tyr Glu
    610                 615                 620                 
Gln Thr Gly Val Gly Pro Leu Pro Val Val Leu Phe Asn Gly Met Pro
625                 630                 635                 640 
Phe Glu Arg Glu Gln Leu Asp Pro Asp Glu Leu Glu Thr Ile Thr Met
                645                 650                 655     
His Lys Ile Leu Glu Thr Thr Thr Phe Phe Gln Arg Ala Val Tyr Leu
            660                 665                 670         
Gly Glu Leu Pro His Asp Gln Asp Val Val Glu Tyr Ile Met Asn Gln
        675                 680                 685             
Pro Asn Val Val Pro Arg Ile Asn Ser Arg Ile Leu Thr Ala Glu Arg
    690                 695                 700                 
Asp Tyr Leu Asp Leu Thr Ala Ser Asn Asn Phe Phe Val Asp Asp Tyr
705                 710                 715                 720 
Ala Arg Phe Thr Ile Leu Asp Ser Gln Gly Lys Thr Ala Ala Val Ala
                725                 730                 735     
Asn Ser Met Asn Tyr Leu Thr Lys Lys Gly Met Ser Ser Lys Glu Ile
            740                 745                 750         
Tyr Asp Asp Ser Phe Ile Arg Pro Val Thr Phe Trp Ile Val Gly Asp
        755                 760                 765             
Phe Asp Ser Pro Ser Gly Arg Gln Leu Leu Tyr Asp Ala Ile Lys His
    770                 775                 780                 
Gln Lys Ser Ser Asn Asn Val Arg Ile Ser Met Ile Asn Asn Pro Ala
785                 790                 795                 800 
Lys Glu Ile Ser Tyr Glu Asn Thr Gln Ile Ser Arg Ala Ile Trp Ala
                805                 810                 815     
Ala Leu Gln Thr Gln Thr Ser Asn Ala Ala Lys Asn Phe Ile Thr Lys
            820                 825                 830         
Met Ala Lys Glu Gly Ala Ala Glu Ala Leu Ala Ala Gly Ala Asp Ile
        835                 840                 845             
Ala Glu Phe Ser Val Gly Gly Met Asp Phe Ser Leu Phe Lys Glu Val
    850                 855                 860                 
Phe Glu Ser Ser Lys Met Asp Phe Ile Leu Ser His Ala Val Tyr Cys
865                 870                 875                 880 
Arg Asp Val Leu Lys Leu Lys Lys Gly Gln Arg Ala Val Ile Ser Asn
                885                 890                 895     
Gly Arg Ile Ile Gly Pro Leu Glu Asp Ser Glu Leu Phe Asn Gln Asp
            900                 905                 910         
Asp Phe His Leu Leu Glu Asn Ile Ile Leu Lys Thr Ser Gly Gln Lys
        915                 920                 925             
Ile Lys Ser His Ile Gln Gln Leu Arg Val Glu Glu Asp Val Ala Ser
    930                 935                 940                 
Asp Leu Val Met Lys Val Asp Ala Leu Leu Ser Ala Gln Pro Lys Gly
945                 950                 955                 960 
Asp Pro Arg Ile Glu Tyr Gln Phe Phe Glu Asp Arg His Ser Ala Ile
                965                 970                 975     
Lys Leu Arg Pro Lys Glu Gly Glu Thr Tyr Phe Asp Val Val Ala Val
            980                 985                 990         
Val Asp Pro Val Thr Arg Glu Ala Gln Arg Leu Ala Pro Leu Leu Leu
        995                 1000                1005            
Val Leu Ala Gln Leu Ile Asn Met Asn Leu Arg Val Phe Met Asn Cys
    1010                1015                1020                
Gln Ser Lys Leu Ser Asp Met Pro Leu Lys Ser Phe Tyr Arg Tyr Val
1025                1030                1035                1040
Leu Glu Pro Glu Ile Ser Phe Thr Ser Asp Asn Ser Phe Ala Lys Gly
                1045                1050                1055    
Pro Ile Ala Lys Phe Leu Asp Met Pro Gln Ser Pro Leu Phe Thr Leu
            1060                1065                1070        
Asn Leu Asn Thr Pro Glu Ser Trp Met Val Glu Ser Val Arg Thr Pro
        1075                1080                1085            
Tyr Asp Leu Asp Asn Ile Tyr Leu Glu Glu Val Asp Ser Val Val Ala
    1090                1095                1100                
Ala Glu Tyr Glu Leu Glu Tyr Leu Leu Leu Glu Gly His Cys Tyr Asp
1105                1110                1115                1120
Ile Thr Thr Gly Gln Pro Pro Arg Gly Leu Gln Phe Thr Leu Gly Thr
                1125                1130                1135    
Ser Ala Asn Pro Val Ile Val Asp Thr Ile Val Met Ala Asn Leu Gly
            1140                1145                1150        
Tyr Phe Gln Leu Lys Ala Asn Pro Gly Ala Trp Ile Leu Arg Leu Arg
        1155                1160                1165            
Lys Gly Arg Ser Glu Asp Ile Tyr Arg Ile Tyr Ser His Asp Gly Thr
    1170                1175                1180                
Asp Ser Pro Pro Asp Ala Asp Glu Val Val Ile Val Leu Asn Asn Phe
1185                1190                1195                1200
Lys Ser Lys Ile Ile Lys Val Lys Val Gln Lys Lys Ala Asp Met Val
                1205                1210                1215    
Asn Glu Asp Leu Leu Ser Asp Gly Thr Ser Glu Asn Glu Ser Gly Phe
            1220                1225                1230        
Trp Asp Ser Phe Lys Trp Gly Phe Thr Gly Gln Lys Thr Glu Glu Val
        1235                1240                1245            
Lys Gln Asp Lys Asp Asp Ile Ile Asn Ile Phe Ser Val Ala Ser Gly
    1250                1255                1260                
His Leu Tyr Glu Arg Phe Leu Arg Ile Met Met Leu Ser Val Leu Lys
1265                1270                1275                1280
Asn Thr Lys Thr Pro Val Lys Phe Trp Phe Leu Lys Asn Tyr Leu Ser
                1285                1290                1295    
Pro Thr Phe Lys Glu Phe Ile Pro Tyr Met Ala Asn Glu Tyr Asn Phe
            1300                1305                1310        
Gln Tyr Glu Leu Val Gln Tyr Lys Trp Pro Arg Trp Leu His Gln Gln
        1315                1320                1325            
Thr Glu Lys Gln Arg Ile Ile Trp Gly Tyr Lys Ile Leu Phe Leu Asp
    1330                1335                1340                
Val Leu Phe Pro Leu Val Val Asp Lys Phe Leu Phe Val Asp Ala Asp
1345                1350                1355                1360
Gln Ile Val Arg Thr Asp Leu Lys Glu Leu Arg Asp Phe Asn Leu Asp
                1365                1370                1375    
Gly Ala Pro Tyr Gly Tyr Thr Pro Phe Cys Asp Ser Arg Arg Glu Met
            1380                1385                1390        
Asp Gly Tyr Arg Phe Trp Lys Ser Gly Tyr Trp Ala Ser His Leu Ala
        1395                1400                1405            
Gly Arg Lys Tyr His Ile Ser Ala Leu Tyr Val Val Asp Leu Lys Lys
    1410                1415                1420                
Phe Arg Lys Ile Ala Ala Gly Asp Arg Leu Arg Gly Gln Tyr Gln Gly
1425                1430                1435                1440
Leu Ser Gln Asp Pro Asn Ser Leu Ser Asn Leu Asp Gln Asp Leu Pro
                1445                1450                1455    
Asn Asn Met Ile His Gln Val Pro Ile Lys Ser Leu Pro Gln Glu Trp
            1460                1465                1470        
Leu Trp Cys Glu Thr Trp Cys Asp Asp Ala Ser Lys Lys Arg Ala Lys
        1475                1480                1485            
Thr Ile Asp Leu Cys Asn Asn Pro Met Thr Lys Glu Pro Lys Leu Glu
    1490                1495                1500                
Ala Ala Val Arg Ile Val Pro Glu Trp Gln Asp Tyr Asp Gln Glu Ile
1505                1510                1515                1520
Lys Gln Leu Gln Ile Arg Phe Gln Lys Glu Lys Glu Thr Gly Ala Leu
                1525                1530                1535    
Tyr Lys Glu Lys Thr Lys Glu Pro Ser Arg Glu Gly Pro Gln Lys Arg
            1540                1545                1550        
Glu Glu Leu
        1555


<210> 981
<211> 142
<212> PRT
<213> Homo sapiens

<400> 981
Met Ala Ala Ala Val Ala Ala Ala Gly Ala Gly Glu Pro Gln Ser Pro
 1               5                  10                  15      
Asp Glu Leu Leu Pro Lys Gly Asp Ala Glu Lys Pro Glu Glu Glu Leu
            20                  25                  30          
Glu Glu Asp Asp Asp Glu Glu Leu Asp Glu Thr Leu Ser Glu Arg Leu
        35                  40                  45              
Trp Gly Leu Thr Glu Met Phe Pro Glu Arg Val Arg Ser Ala Ala Gly
    50                  55                  60                  
Ala Thr Phe Asp Leu Ser Leu Phe Val Ala Gln Lys Met Tyr Arg Phe
65                  70                  75                  80  
Ser Arg Ala Ala Leu Trp Ile Gly Thr Thr Ser Phe Met Ile Leu Val
                85                  90                  95      
Leu Pro Val Val Phe Glu Thr Glu Lys Leu Gln Met Glu Gln Gln Gln
            100                 105                 110         
Gln Leu Gln Gln Arg Gln Ile Leu Leu Gly Pro Asn Thr Gly Leu Ser
        115                 120                 125             
Gly Gly Met Pro Gly Ala Leu Pro Ser Leu Pro Gly Lys Ile
    130                 135                 140         


<210> 982
<211> 142
<212> PRT
<213> Homo sapiens

<400> 982
Met Ala Ala Ala Val Ala Ala Ala Gly Ala Gly Glu Pro Gln Ser Pro
 1               5                  10                  15      
Asp Glu Leu Leu Pro Lys Gly Asp Ala Glu Lys Pro Glu Glu Glu Leu
            20                  25                  30          
Glu Glu Asp Asp Asp Glu Glu Leu Asp Glu Thr Leu Ser Glu Arg Leu
        35                  40                  45              
Trp Gly Leu Thr Glu Met Phe Pro Glu Arg Val Arg Ser Ala Ala Gly
    50                  55                  60                  
Ala Thr Phe Asp Leu Ser Leu Phe Val Ala Gln Lys Met Tyr Arg Phe
65                  70                  75                  80  
Ser Arg Ala Ala Leu Trp Ile Gly Thr Thr Ser Phe Met Ile Leu Val
                85                  90                  95      
Leu Pro Val Val Phe Glu Thr Glu Lys Leu Gln Met Glu Gln Gln Gln
            100                 105                 110         
Gln Leu Gln Gln Arg Gln Ile Leu Leu Gly Pro Asn Thr Gly Leu Ser
        115                 120                 125             
Gly Gly Met Pro Gly Ala Leu Pro Ser Leu Pro Gly Lys Ile
    130                 135                 140         


<210> 983
<211> 383
<212> PRT
<213> Homo sapiens

<400> 983
Met Lys Val Thr Ser Leu Asp Gly Gly His Val Arg Lys Met Leu Arg
 1               5                  10                  15      
Lys Glu Ala Ala Ala Arg Cys Val Val Leu Asp Cys Arg Pro Tyr Leu
            20                  25                  30          
Ala Phe Ala Ala Ser Asn Val Arg Gly Ser Leu Asn Val Asn Leu Asn
        35                  40                  45              
Ser Val Val Leu Arg Arg Ala Arg Gly Gly Ala Val Ser Ala Arg Tyr
    50                  55                  60                  
Val Leu Pro Asp Glu Ala Arg Arg Ala Arg Leu Leu Gln Glu Gly Gly
65                  70                  75                  80  
Gly Gly Val Ala Ala Val Val Val Leu Asp Gln Gly Ser Arg His Trp
                85                  90                  95      
Gln Lys Leu Arg Glu Glu Ser Ala Phe Val Val Leu Thr Ser Leu Leu
            100                 105                 110         
Ala Cys Leu Pro Ala Gly Pro Arg Val Tyr Phe Leu Lys Gly Gly Tyr
        115                 120                 125             
Glu Thr Phe Tyr Ser Glu Tyr Pro Glu Cys Cys Val Asp Val Lys Pro
    130                 135                 140                 
Ile Ser Gln Glu Lys Ile Glu Ser Glu Arg Ala Leu Ile Ser Gln Cys
145                 150                 155                 160 
Gly Lys Pro Val Val Asn Val Ser Tyr Arg Pro Ala Tyr Asp Gln Gly
                165                 170                 175     
Gly Pro Val Glu Ile Leu Pro Phe Leu Tyr Leu Gly Ser Ala Tyr His
            180                 185                 190         
Ala Ser Lys Cys Glu Phe Leu Ala Asn Leu His Ile Thr Ala Leu Leu
        195                 200                 205             
Asn Val Ser Arg Arg Thr Ser Glu Ala Cys Met Thr His Leu His Tyr
    210                 215                 220                 
Lys Trp Ile Pro Val Glu Asp Ser His Thr Ala Asp Ile Ser Ser His
225                 230                 235                 240 
Phe Gln Glu Ala Ile Asp Phe Ile Asp Cys Val Arg Glu Lys Gly Gly
                245                 250                 255     
Lys Val Leu Val His Cys Glu Ala Gly Ile Ser Arg Ser Pro Thr Ile
            260                 265                 270         
Cys Met Ala Tyr Leu Met Lys Thr Lys Gln Phe Arg Leu Lys Glu Ala
        275                 280                 285             
Phe Asp Tyr Ile Lys Gln Arg Arg Ser Met Val Ser Pro Asn Phe Gly
    290                 295                 300                 
Phe Met Gly Gln Leu Leu Gln Tyr Glu Ser Glu Ile Leu Pro Ser Thr
305                 310                 315                 320 
Pro Asn Pro Gln Pro Pro Ser Cys Gln Gly Glu Ala Ala Gly Ser Ser
                325                 330                 335     
Leu Ile Gly His Leu Gln Thr Leu Ser Pro Asp Met Gln Gly Ala Tyr
            340                 345                 350         
Cys Thr Phe Pro Ala Ser Val Leu Ala Pro Val Pro Thr His Ser Thr
        355                 360                 365             
Val Ser Glu Leu Ser Arg Ser Pro Val Ala Thr Ala Gln Ser Cys
    370                 375                 380             


<210> 984
<211> 64
<212> PRT
<213> Homo sapiens

<400> 984
Glu Lys Asn Gly Gly Glu Pro Asp Asp Ala Glu Leu Val Arg Leu Ser
 1               5                  10                  15      
Lys Arg Leu Val Glu Asn Ala Val Leu Lys Ala Val Gln Gln Tyr Leu
            20                  25                  30          
Glu Glu Thr Gln Asn Lys Asn Lys Pro Gly Glu Gly Ser Ser Val Lys
        35                  40                  45              
Thr Glu Ala Ala Asp Gln Asn Gly Asn Asp Asn Glu Asn Asn Arg Lys
    50                  55                  60                  


<210> 985
<211> 359
<212> PRT
<213> Homo sapiens

<400> 985
Met Arg Ala Ala Ala Met Thr Thr Ala Ile Leu Glu Arg Leu Ser Thr
 1               5                  10                  15      
Leu Ser Val Ser Gly Gln Gln Leu Arg Arg Leu Pro Lys Ile Leu Glu
            20                  25                  30          
Asp Gly Leu Pro Lys Met Pro Cys Thr Val Pro Glu Thr Asp Val Pro
        35                  40                  45              
Gln Leu Phe Arg Glu Pro Tyr Ile Arg Thr Gly Tyr Arg Pro Thr Gly
    50                  55                  60                  
His Glu Trp Arg Tyr Tyr Phe Phe Ser Leu Phe Gln Lys His Asn Glu
65                  70                  75                  80  
Val Val Asn Val Trp Thr His Leu Leu Ala Ala Leu Ala Val Leu Leu
                85                  90                  95      
Arg Phe Trp Ala Phe Ala Glu Ala Glu Ala Leu Pro Trp Ala Ser Thr
            100                 105                 110         
His Ser Leu Pro Leu Leu Leu Phe Ile Leu Ser Ser Ile Thr Tyr Leu
        115                 120                 125             
Thr Cys Ser Leu Leu Ala His Leu Leu Gln Ser Lys Ser Glu Leu Ser
    130                 135                 140                 
His Tyr Thr Phe Tyr Phe Val Asp Tyr Val Gly Val Ser Val Tyr Gln
145                 150                 155                 160 
Tyr Gly Ser Ala Leu Ala His Phe Phe Tyr Ser Ser Asp Gln Ala Trp
                165                 170                 175     
Tyr Asp Arg Phe Trp Leu Phe Phe Leu Pro Ala Ala Ala Phe Cys Gly
            180                 185                 190         
Trp Leu Ser Cys Ala Gly Cys Cys Tyr Ala Lys Tyr Arg Tyr Arg Arg
        195                 200                 205             
Pro Tyr Pro Val Met Arg Lys Ile Cys Gln Val Val Pro Ala Gly Leu
    210                 215                 220                 
Ala Phe Ile Leu Asp Ile Ser Pro Val Ala His Arg Val Ala Leu Cys
225                 230                 235                 240 
His Leu Ala Gly Cys Gln Glu Gln Ala Ala Trp Tyr His Thr Leu Gln
                245                 250                 255     
Ile Leu Phe Phe Leu Val Ser Ala Tyr Phe Phe Ser Cys Pro Val Pro
            260                 265                 270         
Glu Lys Tyr Phe Pro Gly Ser Cys Asp Ile Val Gly His Gly His Gln
        275                 280                 285             
Ile Phe His Ala Phe Leu Ser Ile Cys Thr Leu Ser Gln Leu Glu Ala
    290                 295                 300                 
Ile Leu Leu Asp Tyr Gln Gly Arg Gln Glu Ile Phe Leu Gln Arg His
305                 310                 315                 320 
Gly Pro Leu Ser Val His Met Ala Cys Leu Ser Phe Phe Phe Leu Ala
                325                 330                 335     
Ala Cys Ser Ala Ala Thr Ala Ala Leu Leu Arg His Lys Val Lys Ala
            340                 345                 350         
Arg Leu Thr Lys Lys Asp Ser
        355                 


<210> 986
<211> 479
<212> PRT
<213> Homo sapiens

<400> 986
Met Val Gly Arg Ser Arg Arg Arg Gly Ala Ala Lys Trp Ala Ala Val
 1               5                  10                  15      
Arg Ala Lys Ala Gly Pro Thr Leu Thr Asp Glu Asn Gly Asp Asp Leu
            20                  25                  30          
Gly Leu Pro Pro Ser Pro Gly Asp Thr Ser Tyr Tyr Gln Asp Gln Val
        35                  40                  45              
Asp Asp Phe His Glu Ala Arg Ser Arg Ala Ala Leu Ala Lys Gly Trp
    50                  55                  60                  
Asn Glu Val Gln Ser Gly Asp Glu Glu Asp Gly Glu Glu Glu Glu Glu
65                  70                  75                  80  
Glu Val Leu Ala Leu Asp Met Asp Asp Glu Asp Asp Glu Asp Gly Gly
                85                  90                  95      
Asn Ala Gly Glu Glu Glu Glu Glu Glu Asn Ala Asp Asp Asp Gly Gly
            100                 105                 110         
Ser Ser Val Gln Ser Glu Ala Glu Ala Ser Val Asp Pro Ser Leu Ser
        115                 120                 125             
Trp Gly Gln Arg Lys Lys Leu Tyr Tyr Asp Thr Asp Tyr Gly Ser Lys
    130                 135                 140                 
Ser Arg Gly Arg Gln Ser Gln Gln Glu Ala Glu Glu Glu Glu Arg Glu
145                 150                 155                 160 
Glu Glu Glu Glu Ala Gln Ile Ile Gln Arg Arg Leu Ala Gln Ala Leu
                165                 170                 175     
Gln Glu Asp Asp Phe Gly Val Ala Trp Val Glu Ala Phe Ala Lys Pro
            180                 185                 190         
Val Pro Gln Val Asp Glu Ala Glu Thr Arg Val Val Lys Asp Leu Ala
        195                 200                 205             
Lys Val Ser Val Lys Glu Lys Leu Lys Met Leu Arg Lys Glu Ser Pro
    210                 215                 220                 
Glu Leu Leu Glu Leu Ile Glu Asp Leu Lys Val Lys Leu Thr Glu Val
225                 230                 235                 240 
Lys Asp Glu Leu Glu Pro Leu Leu Glu Leu Val Glu Gln Gly Ile Ile
                245                 250                 255     
Pro Pro Gly Lys Gly Ser Gln Tyr Leu Arg Thr Lys Tyr Asn Leu Tyr
            260                 265                 270         
Leu Asn Tyr Cys Ser Asn Ile Ser Phe Tyr Leu Ile Leu Lys Ala Arg
        275                 280                 285             
Arg Val Pro Ala His Gly His Pro Val Ile Glu Arg Leu Val Thr Tyr
    290                 295                 300                 
Arg Asn Leu Ile Asn Lys Leu Ser Val Val Asp Gln Lys Leu Ser Ser
305                 310                 315                 320 
Glu Ile Arg His Leu Leu Thr Leu Lys Asp Asp Ala Val Lys Lys Glu
                325                 330                 335     
Leu Ile Pro Lys Ala Lys Ser Thr Lys Pro Lys Pro Lys Ser Val Ser
            340                 345                 350         
Lys Thr Ser Ala Ala Ala Cys Ala Val Thr Asp Leu Ser Asp Asp Ser
        355                 360                 365             
Asp Phe Asp Glu Lys Ala Lys Leu Lys Tyr Tyr Lys Glu Ile Glu Asp
    370                 375                 380                 
Arg Gln Lys Leu Lys Arg Lys Lys Glu Glu Asn Ser Thr Glu Glu Gln
385                 390                 395                 400 
Ala Leu Glu Asp Gln Asn Ala Lys Arg Ala Ile Thr Tyr Gln Ile Ala
                405                 410                 415     
Lys Asn Arg Gly Leu Thr Pro Arg Arg Lys Lys Ile Asp Arg Asn Pro
            420                 425                 430         
Arg Val Lys His Arg Glu Lys Phe Arg Arg Ala Lys Ile Arg Arg Arg
        435                 440                 445             
Gly Gln Val Arg Glu Val Arg Lys Glu Glu Gln Arg Tyr Ser Gly Glu
    450                 455                 460                 
Leu Ser Gly Ile Arg Ala Gly Val Lys Lys Ser Ile Lys Leu Lys
465                 470                 475                 


<210> 987
<211> 91
<212> PRT
<213> Homo sapiens

<400> 987
Met Ala Ala Ser Ser Arg Ala Gln Val Leu Ser Leu Tyr Arg Ala Met
 1               5                  10                  15      
Leu Arg Glu Ser Lys Arg Phe Ser Ala Tyr Asn Tyr Arg Thr Tyr Ala
            20                  25                  30          
Val Arg Arg Ile Arg Asp Ala Phe Arg Glu Asn Lys Asn Val Lys Asp
        35                  40                  45              
Pro Val Glu Ile Gln Thr Leu Val Asn Lys Ala Lys Arg Asp Leu Gly
    50                  55                  60                  
Val Ile Arg Arg Gln Val His Ile Gly Gln Leu Tyr Ser Thr Asp Lys
65                  70                  75                  80  
Leu Ile Ile Glu Asn Arg Asp Met Pro Arg Thr
                85                  90      


<210> 988
<211> 421
<212> PRT
<213> Homo sapiens

<400> 988
Met Arg Trp Ile Leu Phe Ile Gly Ala Leu Ile Gly Ser Ser Ile Cys
 1               5                  10                  15      
Gly Arg Glu Lys Phe Phe Gly Asp Gln Val Leu Arg Ile Asn Val Arg
            20                  25                  30          
Asn Gly Asp Glu Ile Ser Lys Leu Ser Gln Leu Val Asn Ser Asn Asn
        35                  40                  45              
Leu Lys Leu Asn Phe Trp Lys Ser Pro Ser Ser Phe Asn Arg Pro Val
    50                  55                  60                  
Asp Val Leu Val Pro Ser Val Ser Leu Gln Ala Phe Lys Ser Phe Leu
65                  70                  75                  80  
Arg Ser Gln Gly Leu Glu Tyr Ala Val Thr Ile Glu Asp Leu Gln Ala
                85                  90                  95      
Leu Leu Asp Asn Glu Asp Asp Glu Met Gln His Asn Glu Gly Gln Glu
            100                 105                 110         
Arg Ser Ser Asn Asn Phe Asn Tyr Gly Ala Tyr His Ser Leu Glu Ala
        115                 120                 125             
Ile Tyr His Glu Met Asp Asn Ile Ala Ala Asp Phe Pro Asp Leu Ala
    130                 135                 140                 
Arg Arg Val Lys Ile Gly His Ser Phe Glu Asn Arg Pro Met Tyr Val
145                 150                 155                 160 
Leu Lys Phe Ser Thr Gly Lys Gly Val Arg Arg Pro Ala Val Trp Leu
                165                 170                 175     
Asn Ala Gly Ile His Ser Arg Glu Trp Ile Ser Gln Ala Thr Ala Ile
            180                 185                 190         
Trp Thr Ala Arg Lys Ile Val Ser Asp Tyr Gln Arg Asp Pro Ala Ile
        195                 200                 205             
Thr Ser Ile Leu Glu Lys Met Asp Ile Phe Leu Leu Pro Val Ala Asn
    210                 215                 220                 
Pro Asp Gly Tyr Val Tyr Thr Gln Thr Gln Asn Arg Leu Trp Arg Lys
225                 230                 235                 240 
Thr Arg Ser Arg Asn Pro Gly Ser Ser Cys Ile Gly Ala Asp Pro Asn
                245                 250                 255     
Arg Asn Trp Asn Ala Ser Phe Ala Gly Lys Gly Ala Ser Asp Asn Pro
            260                 265                 270         
Cys Ser Glu Val Tyr His Gly Pro His Ala Asn Ser Glu Val Glu Val
        275                 280                 285             
Lys Ser Val Val Asp Phe Ile Gln Lys His Gly Asn Phe Lys Gly Phe
    290                 295                 300                 
Ile Asp Leu His Ser Tyr Ser Gln Leu Leu Met Tyr Pro Tyr Gly Tyr
305                 310                 315                 320 
Ser Val Lys Lys Ala Pro Asp Ala Glu Glu Leu Asp Lys Val Ala Arg
                325                 330                 335     
Leu Ala Ala Lys Ala Leu Ala Ser Val Ser Gly Thr Glu Tyr Gln Val
            340                 345                 350         
Gly Pro Thr Cys Thr Thr Val Tyr Pro Ala Ser Gly Ser Ser Ile Asp
        355                 360                 365             
Trp Ala Tyr Asp Asn Gly Ile Lys Phe Ala Phe Thr Phe Glu Leu Arg
    370                 375                 380                 
Asp Thr Gly Thr Tyr Gly Phe Leu Leu Pro Ala Asn Gln Ile Ile Pro
385                 390                 395                 400 
Thr Ala Glu Glu Thr Trp Leu Gly Leu Lys Thr Ile Met Glu His Val
                405                 410                 415     
Arg Asp Asn Leu Tyr
            420     


<210> 989
<211> 72
<212> PRT
<213> Homo sapiens

<400> 989
Met Ser Ser Lys Thr Ala Ser Thr Asn Asn Ile Ala Gln Ala Arg Arg
 1               5                  10                  15      
Thr Val Gln Gln Leu Arg Leu Glu Ala Ser Ile Glu Arg Ile Lys Val
            20                  25                  30          
Ser Lys Ala Ser Ala Asp Leu Met Ser Tyr Cys Glu Glu His Ala Arg
        35                  40                  45              
Ser Asp Pro Leu Leu Ile Gly Ile Pro Thr Ser Glu Asn Pro Phe Lys
    50                  55                  60                  
Asp Lys Lys Thr Cys Ile Ile Leu
65                  70          


<210> 990
<211> 406
<212> PRT
<213> Homo sapiens

<400> 990
Met Glu Gln Phe Asn Pro Gly Leu Arg Asn Leu Ile Asn Leu Gly Lys
 1               5                  10                  15      
Asn Tyr Glu Lys Ala Val Asn Ala Met Ile Leu Ala Gly Lys Ala Tyr
            20                  25                  30          
Tyr Asp Gly Val Ala Lys Ile Gly Glu Ile Ala Thr Gly Ser Pro Val
        35                  40                  45              
Ser Thr Glu Leu Gly His Val Leu Ile Glu Ile Ser Ser Thr His Lys
    50                  55                  60                  
Lys Leu Asn Glu Ser Leu Asp Glu Asn Phe Lys Lys Phe His Lys Glu
65                  70                  75                  80  
Ile Ile His Glu Leu Glu Lys Lys Ile Glu Leu Asp Val Lys Tyr Met
                85                  90                  95      
Asn Ala Thr Leu Lys Arg Tyr Gln Thr Glu His Lys Asn Lys Leu Glu
            100                 105                 110         
Ser Leu Glu Lys Ser Gln Ala Glu Leu Lys Lys Ile Arg Arg Lys Ser
        115                 120                 125             
Gln Gly Ser Arg Asn Ala Leu Lys Tyr Glu His Lys Glu Ile Glu Tyr
    130                 135                 140                 
Val Glu Thr Val Thr Ser Arg Gln Ser Glu Ile Gln Lys Phe Ile Ala
145                 150                 155                 160 
Asp Gly Cys Lys Glu Ala Leu Leu Glu Glu Lys Arg Arg Phe Cys Phe
                165                 170                 175     
Leu Val Asp Lys His Cys Gly Phe Ala Asn His Ile His Tyr Tyr His
            180                 185                 190         
Leu Gln Ser Ala Glu Leu Leu Asn Ser Lys Leu Pro Arg Trp Gln Glu
        195                 200                 205             
Thr Cys Val Asp Ala Ile Lys Val Pro Glu Lys Ile Met Asn Met Ile
    210                 215                 220                 
Glu Glu Ile Lys Thr Pro Ala Ser Thr Pro Val Ser Gly Thr Pro Gln
225                 230                 235                 240 
Ala Ser Pro Met Ile Glu Arg Ser Asn Val Val Arg Lys Asp Tyr Asp
                245                 250                 255     
Thr Leu Ser Lys Cys Ser Pro Lys Met Pro Pro Ala Pro Ser Gly Arg
            260                 265                 270         
Ala Tyr Thr Ser Pro Leu Ile Asp Met Phe Asn Asn Pro Ala Thr Ala
        275                 280                 285             
Ala Pro Asn Ser Gln Arg Val Asn Asn Ser Thr Gly Thr Ser Glu Asp
    290                 295                 300                 
Pro Ser Leu Gln Arg Ser Val Ser Val Ala Thr Gly Leu Asn Met Met
305                 310                 315                 320 
Lys Lys Gln Lys Val Lys Thr Ile Phe Pro His Thr Ala Gly Ser Asn
                325                 330                 335     
Lys Thr Leu Leu Ser Phe Ala Gln Gly Asp Val Ile Thr Leu Leu Ile
            340                 345                 350         
Pro Glu Glu Lys Asp Gly Trp Leu Tyr Gly Glu His Asp Val Ser Lys
        355                 360                 365             
Ala Arg Gly Trp Phe Pro Ser Ser Tyr Thr Lys Leu Leu Glu Glu Asn
    370                 375                 380                 
Glu Thr Glu Ala Val Thr Val Pro Thr Pro Ser Pro Thr Pro Val Arg
385                 390                 395                 400 
Ser Phe Ser Gly Glu Ala
                405     


<210> 991
<211> 1249
<212> PRT
<213> Homo sapiens

<400> 991
Gln Met Ile Pro Ser Asn Ser Thr Arg Leu Pro Val Ala Tyr Gln Gly
 1               5                  10                  15      
Asn Gln Gly Leu Asn Gln Ser Phe Ser Glu Gln Gln Val Asp Trp Thr
            20                  25                  30          
Gln Gln Cys Ile Ser Lys Gly Leu Thr Tyr Pro Asp Tyr Arg Pro Pro
        35                  40                  45              
Pro Lys Leu Tyr Arg Tyr Ser Pro Gln Ser Phe Leu Pro Asp Ser Thr
    50                  55                  60                  
Ile Gln Lys Gln Asn Phe Ile Pro His Thr Ser Leu Gln Val Lys Asn
65                  70                  75                  80  
Ser Gln Leu Pro Asn Ser Val Leu Thr Leu Pro Ser Arg Gln Thr Ser
                85                  90                  95      
Ala Val Pro Ser Gln Gln Tyr Ala Thr Gln Thr Asp Lys Arg Pro Pro
            100                 105                 110         
Pro Pro Pro Tyr Asn Cys Arg Tyr Gly Ser Gln Pro Leu Gln Ser Thr
        115                 120                 125             
Gln His Ile Thr Lys His Leu Ser Met Glu Val Pro Gln Ser Gln Glu
    130                 135                 140                 
Met Leu Ser Ser Glu Ile Arg Thr Ser Phe Gln Gln Gln Trp Gln Asn
145                 150                 155                 160 
Pro Asn Glu Asn Val Ser Thr Ile Gly Asn Phe Thr Asn Leu Lys Val
                165                 170                 175     
Asn Thr Asn Ser Lys Gln Pro Phe Asn Gly Pro Ile Arg Ser Ser Val
            180                 185                 190         
Asp Gly Val Gln Thr Leu Ala Gln Thr Asn Glu Glu Lys Ile Met Asp
        195                 200                 205             
Ser Cys Asn Pro Thr Ser Asn Gln Val Leu Asp Thr Ser Val Ala Lys
    210                 215                 220                 
Glu Lys Leu Val Arg Asp Ile Lys Thr Leu Val Glu Ile Lys Gln Lys
225                 230                 235                 240 
Phe Ser Glu Leu Ala Arg Lys Ile Lys Ile Asn Lys Asp Leu Leu Met
                245                 250                 255     
Ala Ala Gly Cys Ile Lys Met Thr Asn Thr Ser Tyr Ser Glu Pro Ala
            260                 265                 270         
Gln Asn Ser Lys Leu Ser Leu Lys Gln Thr Ala Lys Ile Gln Ser Gly
        275                 280                 285             
Pro Gln Ile Thr Pro Val Met Pro Glu Asn Ala Glu Arg Gln Thr Pro
    290                 295                 300                 
Thr Val Val Glu Ser Ala Glu Thr Asn Lys Thr Gln Cys Met Leu Asn
305                 310                 315                 320 
Ser Asp Ile Gln Glu Val Asn Cys Arg Arg Phe Asn Gln Val Asp Ser
                325                 330                 335     
Val Leu Pro Asn Pro Val Tyr Ser Glu Lys Arg Pro Met Pro Asp Pro
            340                 345                 350         
Ser His Asp Val Lys Val Leu Thr Ser Lys Thr Ser Ala Val Glu Met
        355                 360                 365             
Thr Gln Ala Val Leu Asn Thr Gln Leu Ser Ser Glu Asn Val Thr Lys
    370                 375                 380                 
Val Glu Gln Asn Ser Pro Ala Val Cys Glu Thr Ile Ser Val Pro Lys
385                 390                 395                 400 
Ser Met Ser Thr Glu Glu Tyr Lys Ser Lys Ile Gln Asn Glu Asn Met
                405                 410                 415     
Leu Leu Leu Ala Leu Leu Ser Gln Ala Arg Lys Thr Gln Lys Thr Val
            420                 425                 430         
Leu Lys Asp Ala Asn Gln Thr Ile Gln Asp Ser Lys Pro Asp Ser Cys
        435                 440                 445             
Glu Met Asn Pro Asn Thr Gln Met Thr Gly Asn Gln Leu Asn Leu Lys
    450                 455                 460                 
Asn Met Glu Thr Pro Ser Thr Ser Asn Val Ser Gly Arg Val Leu Asp
465                 470                 475                 480 
Asn Ser Phe Cys Ser Gly Gln Glu Ser Ser Thr Lys Gly Met Pro Ala
                485                 490                 495     
Lys Ser Asp Ser Ser Cys Ser Met Glu Val Leu Ala Thr Cys Leu Ser
            500                 505                 510         
Leu Trp Lys Lys Gln Pro Ser Asp Thr Ala Lys Glu Lys Glu Cys Asp
        515                 520                 525             
Lys Leu Arg Thr Asn Thr Thr Ala Val Gly Ile Ser Lys Pro Ala Asn
    530                 535                 540                 
Ile His Val Lys Ser Pro Cys Ser Val Val Gly Asn Ser Asn Ser Gln
545                 550                 555                 560 
Asn Lys Ile Ser Asn Pro Ser Gln Gln Thr Ala Leu Ser Met Val Met
                565                 570                 575     
His Asn Tyr Glu Ser Ser Gly Ile Asn Ile Thr Lys Gly Thr Glu Leu
            580                 585                 590         
Gln Ile Ala Val Val Ser Pro Leu Val Leu Ser Glu Val Lys Thr Leu
        595                 600                 605             
Ser Val Lys Gly Ile Thr Pro Ala Val Leu Pro Glu Thr Val Tyr Pro
    610                 615                 620                 
Val Ile Lys Glu Gly Ser Val Cys Ser Leu Gln Asn Gln Leu Ala Glu
625                 630                 635                 640 
Asn Ala Lys Ala Thr Ala Ala Leu Lys Val Asp Val Ser Gly Pro Val
                645                 650                 655     
Ala Ser Thr Ala Thr Ser Thr Lys Ile Phe Pro Leu Thr Gln Lys Glu
            660                 665                 670         
Lys Gln Asn Glu Ser Thr Asn Gly Asn Ser Glu Val Thr Pro Asn Val
        675                 680                 685             
Asn Gln Gly Lys His Asn Lys Leu Glu Ser Ala Ile His Ser Pro Met
    690                 695                 700                 
Asn Asp Gln Gln Ile Ser Gln Glu Ser Arg Asn Ser Thr Val Val Ser
705                 710                 715                 720 
Ser Asp Thr Leu Gln Ile Asp Asn Ile Cys Ser Leu Val Glu Gly Asp
                725                 730                 735     
Thr Ser Tyr Asn Ser Gln Ile Ala Lys Ile Phe Ser Ser Leu Pro Leu
            740                 745                 750         
Lys Met Val Glu Pro Gln Lys Pro Ser Leu Pro Asn Gln Gln Gly Ile
        755                 760                 765             
Gly Ser Arg Glu Pro Glu Lys Gln Leu Asp Asn Thr Thr Glu Asn Lys
    770                 775                 780                 
Asp Phe Gly Phe Gln Lys Asp Lys Pro Val Gln Cys Thr Asp Val Ser
785                 790                 795                 800 
His Lys Ile Cys Asp Gln Ser Lys Ser Glu Pro Pro Leu Glu Ser Ser
                805                 810                 815     
Phe Asn Asn Leu Glu Thr Asn Arg Val Ile Leu Glu Lys Ser Ser Leu
            820                 825                 830         
Glu His Ala Thr Glu Lys Ser Thr Ala Asn Asp Thr Cys Ser Ser Ala
        835                 840                 845             
Ala Ile Gln Glu Asp Ile Tyr Pro Gln Glu Ile Asp Ala Ser Ser Asn
    850                 855                 860                 
Tyr Thr Pro Gln Asp Pro Ala Arg Asn Glu Ile His Ser Asp Lys Ala
865                 870                 875                 880 
Pro Val Leu Tyr Leu His Asp Gln Leu Ser Glu Leu Leu Lys Glu Phe
                885                 890                 895     
Pro Tyr Gly Ile Glu Ala Val Asn Thr Arg Glu Gly Ser Val Gly Gln
            900                 905                 910         
Gln Thr Thr Tyr Gln Thr Ser Glu Asp Gln Thr Ala Asp Lys Thr Ser
        915                 920                 925             
Ser Asp Ser Lys Asp Pro Ala Asp Gln Ile Gln Ile Thr Ile Leu Ser
    930                 935                 940                 
Ser Glu Gln Met Lys Glu Ile Phe Pro Glu Gln Asp Asp Gln Pro Tyr
945                 950                 955                 960 
Val Val Asp Lys Leu Ala Glu Pro Gln Lys Glu Glu Pro Ile Thr Glu
                965                 970                 975     
Val Val Ser Gln Cys Asp Leu Gln Ala Pro Ala Ala Gly Gln Ser Arg
            980                 985                 990         
Asp Ser Val Ile Leu Asp Ser Glu Lys Asp Asp Ile His Cys Cys Ala
        995                 1000                1005            
Leu Gly Trp Leu Ser Met Val Tyr Glu Gly Val Pro Gln Cys Gln Cys
    1010                1015                1020                
Asn Ser Ile Lys Asn Ser Ser Ser Glu Glu Glu Lys Gln Lys Glu Gln
1025                1030                1035                1040
Cys Ser Pro Leu Asp Thr Asn Ser Cys Lys Gln Gly Glu Arg Thr Ser
                1045                1050                1055    
Asp Arg Asp Val Thr Val Val Gln Phe Lys Ser Leu Val Asn Asn Pro
            1060                1065                1070        
Lys Thr Pro Pro Asp Gly Lys Ser His Phe Pro Glu Leu Gln Asp Asp
        1075                1080                1085            
Ser Arg Lys Asp Thr Pro Lys Thr Lys His Lys Ser Leu Pro Arg Thr
    1090                1095                1100                
Glu Gln Glu Leu Val Ala Gly Gln Phe Ser Ser Lys Cys Asp Lys Leu
1105                1110                1115                1120
Asn Pro Leu Gln Asn His Lys Arg Lys Lys Leu Arg Phe His Glu Val
                1125                1130                1135    
Thr Phe His Ser Ser Asn Lys Met Thr Ala Ser Tyr Glu Gln Ala Ser
            1140                1145                1150        
Gln Glu Thr Arg Gln Lys Lys His Val Thr Gln Asn Ser Arg Pro Leu
        1155                1160                1165            
Lys Thr Lys Thr Ala Phe Leu Pro Asn Lys Asp Val Tyr Lys Lys His
    1170                1175                1180                
Ser Ser Leu Gly Gln Ser Leu Ser Pro Glu Lys Ile Lys Leu Lys Leu
1185                1190                1195                1200
Lys Ser Val Ser Phe Lys Gln Lys Arg Lys Leu Asp Gln Gly Asn Val
                1205                1210                1215    
Leu Asp Met Glu Val Lys Lys Lys Lys His Asp Thr Gln Asp Ala Glu
            1220                1225                1230        
Lys Asn Asp Leu Ala Ser Lys Gly His Ser Pro His Pro Gln Arg Leu
        1235                1240                1245            
Lys
    


<210> 992
<211> 1596
<212> PRT
<213> Homo sapiens

<400> 992
Arg Ala Arg Val Arg Val His Asp Leu His Val Gly Ile Thr Lys Arg
 1               5                  10                  15      
Leu Lys Thr Met Glu Val Leu Glu Gly Glu Ser Cys Ser Phe Glu Cys
            20                  25                  30          
Val Leu Ser His Glu Ser Ala Ser Asp Pro Ala Met Trp Thr Val Gly
        35                  40                  45              
Gly Lys Thr Val Gly Ser Ser Ser Arg Phe Gln Ala Thr Arg Gln Gly
    50                  55                  60                  
Arg Lys Tyr Ile Leu Val Val Arg Glu Ala Ala Pro Ser Asp Ala Gly
65                  70                  75                  80  
Glu Val Val Phe Ser Val Arg Gly Leu Thr Ser Lys Ala Ser Leu Ile
                85                  90                  95      
Val Arg Glu Arg Pro Ala Ala Ile Ile Lys Pro Leu Glu Asp Gln Trp
            100                 105                 110         
Val Ala Pro Gly Glu Asp Val Glu Leu Arg Cys Glu Leu Ser Arg Ala
        115                 120                 125             
Gly Thr Pro Val His Trp Leu Lys Asp Arg Lys Ala Ile Arg Lys Ser
    130                 135                 140                 
Gln Lys Tyr Asp Val Val Cys Glu Gly Thr Met Ala Met Leu Val Ile
145                 150                 155                 160 
Arg Gly Ala Ser Leu Lys Asp Ala Gly Glu Tyr Thr Cys Glu Val Glu
                165                 170                 175     
Ala Ser Lys Ser Thr Ala Ser Leu His Val Glu Glu Lys Ala Asn Cys
            180                 185                 190         
Phe Thr Glu Glu Leu Thr Asn Leu Gln Val Glu Glu Lys Gly Thr Ala
        195                 200                 205             
Val Phe Thr Cys Lys Thr Glu His Pro Ala Ala Thr Val Thr Trp Arg
    210                 215                 220                 
Lys Gly Leu Leu Glu Leu Arg Ala Ser Gly Lys His Gln Pro Ser Gln
225                 230                 235                 240 
Glu Gly Leu Thr Leu Arg Leu Thr Ile Ser Ala Leu Glu Lys Ala Asp
                245                 250                 255     
Ser Asp Thr Tyr Thr Cys Asp Ile Gly Gln Ala Gln Ser Arg Ala Gln
            260                 265                 270         
Leu Leu Val Gln Gly Arg Arg Val His Ile Ile Glu Asp Leu Glu Asp
        275                 280                 285             
Val Asp Val Gln Glu Gly Ser Ser Ala Thr Phe Arg Cys Arg Ile Ser
    290                 295                 300                 
Pro Ala Asn Tyr Glu Pro Val His Trp Phe Leu Asp Lys Thr Pro Leu
305                 310                 315                 320 
His Ala Asn Glu Leu Asn Glu Ile Asp Ala Gln Pro Gly Gly Tyr His
                325                 330                 335     
Val Leu Thr Leu Arg Gln Leu Ala Leu Lys Asp Ser Gly Thr Ile Tyr
            340                 345                 350         
Phe Glu Ala Gly Asp Gln Arg Ala Ser Ala Ala Leu Arg Val Thr Glu
        355                 360                 365             
Lys Pro Ser Val Phe Ser Arg Glu Leu Thr Asp Ala Thr Ile Thr Glu
    370                 375                 380                 
Gly Glu Asp Leu Thr Leu Val Cys Glu Thr Ser Thr Cys Asp Ile Pro
385                 390                 395                 400 
Val Cys Trp Thr Lys Asp Gly Lys Thr Leu Arg Gly Ser Ala Arg Cys
                405                 410                 415     
Gln Leu Ser His Glu Gly His Arg Ala Gln Leu Leu Ile Thr Gly Ala
            420                 425                 430         
Thr Leu Gln Asp Ser Gly Arg Tyr Lys Cys Glu Ala Gly Gly Ala Cys
        435                 440                 445             
Ser Ser Ser Ile Val Arg Val His Ala Arg Pro Val Arg Phe Gln Glu
    450                 455                 460                 
Ala Leu Lys Asp Leu Glu Val Leu Glu Gly Gly Ala Ala Thr Leu Arg
465                 470                 475                 480 
Cys Val Leu Ser Ser Val Ala Ala Pro Val Lys Trp Cys Tyr Gly Asn
                485                 490                 495     
Asn Val Leu Arg Pro Gly Asp Lys Tyr Ser Leu Arg Gln Glu Gly Ala
            500                 505                 510         
Met Leu Glu Leu Val Val Arg Asn Leu Arg Pro Gln Asp Ser Gly Arg
        515                 520                 525             
Tyr Ser Cys Ser Phe Gly Asp Gln Thr Thr Ser Ala Thr Leu Thr Val
    530                 535                 540                 
Thr Ala Leu Pro Ala Gln Phe Ile Gly Lys Leu Arg Asn Lys Glu Ala
545                 550                 555                 560 
Thr Glu Gly Ala Thr Ala Thr Leu Arg Cys Glu Leu Ser Lys Ala Ala
                565                 570                 575     
Pro Val Glu Trp Arg Lys Gly Ser Glu Thr Leu Arg Asp Gly Asp Arg
            580                 585                 590         
Tyr Cys Leu Arg Gln Asp Gly Ala Met Cys Glu Leu Gln Ile Arg Gly
        595                 600                 605             
Leu Ala Met Val Asp Ala Ala Glu Tyr Ser Cys Val Cys Gly Glu Glu
    610                 615                 620                 
Arg Thr Ser Ala Ser Leu Thr Ile Arg Pro Met Pro Ala His Phe Ile
625                 630                 635                 640 
Gly Arg Leu Arg His Gln Glu Ser Ile Glu Gly Ala Thr Ala Thr Leu
                645                 650                 655     
Arg Cys Glu Leu Ser Lys Ala Ala Pro Val Glu Trp Arg Lys Gly Arg
            660                 665                 670         
Glu Ser Leu Arg Asp Gly Asp Arg His Ser Leu Arg Gln Asp Gly Ala
        675                 680                 685             
Val Cys Glu Leu Gln Ile Cys Gly Leu Ala Val Ala Asp Ala Gly Glu
    690                 695                 700                 
Tyr Ser Cys Val Cys Gly Glu Glu Arg Thr Ser Ala Thr Leu Thr Val
705                 710                 715                 720 
Lys Ala Leu Pro Ala Lys Phe Thr Glu Gly Leu Arg Asn Glu Glu Ala
                725                 730                 735     
Val Glu Gly Ala Thr Ala Met Leu Trp Cys Glu Leu Ser Lys Val Ala
            740                 745                 750         
Pro Val Glu Trp Arg Lys Gly Pro Glu Asn Leu Arg Asp Gly Asp Arg
        755                 760                 765             
Tyr Ile Leu Arg Gln Glu Gly Thr Arg Cys Glu Leu Gln Ile Cys Gly
    770                 775                 780                 
Leu Ala Met Ala Asp Ala Gly Glu Tyr Leu Cys Val Cys Gly Gln Glu
785                 790                 795                 800 
Arg Thr Ser Ala Thr Leu Thr Ile Arg Ala Leu Pro Ala Arg Phe Ile
                805                 810                 815     
Glu Asp Val Lys Asn Gln Glu Ala Arg Glu Gly Ala Thr Ala Val Leu
            820                 825                 830         
Gln Cys Glu Leu Asn Ser Ala Ala Pro Val Glu Trp Arg Lys Gly Ser
        835                 840                 845             
Glu Thr Leu Arg Asp Gly Asp Arg Tyr Ser Leu Arg Gln Asp Gly Thr
    850                 855                 860                 
Lys Cys Glu Leu Gln Ile Arg Gly Leu Ala Met Ala Asp Thr Gly Glu
865                 870                 875                 880 
Tyr Ser Cys Val Cys Gly Gln Glu Arg Thr Ser Ala Met Leu Thr Val
                885                 890                 895     
Arg Ala Leu Pro Ile Lys Phe Thr Glu Gly Leu Arg Asn Glu Glu Ala
            900                 905                 910         
Thr Glu Gly Ala Thr Ala Val Leu Arg Cys Glu Leu Ser Lys Met Ala
        915                 920                 925             
Pro Val Glu Trp Trp Lys Gly His Glu Thr Leu Arg Asp Gly Asp Arg
    930                 935                 940                 
His Ser Leu Arg Gln Asp Gly Ala Arg Cys Glu Leu Gln Ile Arg Gly
945                 950                 955                 960 
Leu Val Ala Glu Asp Ala Gly Glu Tyr Leu Cys Met Cys Gly Lys Glu
                965                 970                 975     
Arg Thr Ser Ala Met Leu Thr Val Arg Ala Met Pro Ser Lys Phe Ile
            980                 985                 990         
Glu Gly Leu Arg Asn Glu Glu Ala Thr Glu Gly Asp Thr Ala Thr Leu
        995                 1000                1005            
Trp Cys Glu Leu Ser Lys Ala Ala Pro Val Glu Trp Arg Lys Gly His
    1010                1015                1020                
Glu Thr Leu Arg Asp Gly Asp Arg His Ser Leu Arg Gln Asp Gly Ser
1025                1030                1035                1040
Arg Cys Glu Leu Gln Ile Arg Gly Leu Ala Val Val Asp Ala Gly Glu
                1045                1050                1055    
Tyr Ser Cys Val Cys Gly Gln Glu Arg Thr Ser Ala Thr Leu Thr Val
            1060                1065                1070        
Arg Ala Leu Pro Ala Arg Phe Ile Glu Asp Val Lys Asn Gln Glu Ala
        1075                1080                1085            
Arg Glu Gly Ala Thr Ala Val Leu Gln Cys Glu Leu Ser Lys Ala Ala
    1090                1095                1100                
Pro Val Glu Trp Arg Lys Gly Ser Glu Thr Leu Arg Gly Gly Asp Arg
1105                1110                1115                1120
Tyr Ser Leu Arg Gln Asp Gly Thr Arg Cys Glu Leu Gln Ile His Gly
                1125                1130                1135    
Leu Ser Val Ala Asp Thr Gly Glu Tyr Ser Cys Val Cys Gly Gln Glu
            1140                1145                1150        
Arg Thr Ser Ala Thr Leu Thr Val Arg Ala Leu Pro Ala Arg Phe Thr
        1155                1160                1165            
Gln Asp Leu Lys Thr Lys Glu Ala Ser Glu Gly Ala Thr Ala Thr Leu
    1170                1175                1180                
Gln Cys Glu Leu Ser Lys Val Ala Pro Val Glu Trp Lys Lys Gly Pro
1185                1190                1195                1200
Glu Thr Leu Arg Asp Gly Gly Arg Tyr Ser Leu Lys Gln Asp Gly Thr
                1205                1210                1215    
Arg Cys Glu Leu Gln Ile His Asp Leu Ser Val Ala Asp Ala Gly Glu
            1220                1225                1230        
Tyr Ser Cys Met Cys Gly Gln Glu Arg Thr Ser Ala Thr Leu Thr Val
        1235                1240                1245            
Arg Ala Leu Pro Ala Arg Phe Thr Glu Gly Leu Arg Asn Glu Glu Ala
    1250                1255                1260                
Met Glu Gly Ala Thr Ala Thr Leu Gln Cys Glu Leu Ser Lys Ala Ala
1265                1270                1275                1280
Pro Val Glu Trp Arg Lys Gly Leu Glu Ala Leu Arg Asp Gly Asp Lys
                1285                1290                1295    
Tyr Ser Leu Arg Gln Asp Gly Ala Val Cys Glu Leu Gln Ile His Gly
            1300                1305                1310        
Leu Ala Met Ala Asp Asn Gly Val Tyr Ser Cys Val Cys Gly Gln Glu
        1315                1320                1325            
Arg Thr Ser Ala Thr Leu Thr Val Arg Ala Leu Pro Ala Arg Phe Ile
    1330                1335                1340                
Glu Asp Met Arg Asn Gln Lys Ala Thr Glu Gly Ala Thr Val Thr Leu
1345                1350                1355                1360
Gln Cys Lys Leu Arg Lys Ala Ala Pro Val Glu Trp Arg Lys Gly Pro
                1365                1370                1375    
Asn Thr Leu Lys Asp Gly Asp Arg Tyr Ser Leu Lys Gln Asp Gly Thr
            1380                1385                1390        
Ser Cys Glu Leu Gln Ile Arg Gly Leu Val Ile Ala Asp Ala Gly Glu
        1395                1400                1405            
Tyr Ser Cys Ile Cys Glu Gln Glu Arg Thr Ser Ala Thr Leu Thr Val
    1410                1415                1420                
Arg Ala Leu Pro Ala Arg Phe Ile Glu Asp Val Arg Asn His Glu Ala
1425                1430                1435                1440
Thr Glu Gly Ala Thr Ala Val Leu Gln Cys Glu Leu Ser Lys Ala Ala
                1445                1450                1455    
Pro Val Glu Trp Arg Lys Gly Ser Glu Thr Leu Arg Asp Gly Asp Arg
            1460                1465                1470        
Tyr Ser Leu Arg Gln Asp Gly Thr Arg Cys Glu Leu Gln Ile Arg Gly
        1475                1480                1485            
Leu Ala Val Glu Asp Thr Gly Glu Tyr Leu Cys Val Cys Gly Gln Glu
    1490                1495                1500                
Arg Thr Ser Ala Thr Leu Thr Val Arg Ala Leu Pro Ala Arg Phe Ile
1505                1510                1515                1520
Asp Asn Met Thr Asn Gln Glu Ala Arg Glu Gly Ala Thr Ala Thr Leu
                1525                1530                1535    
His Cys Glu Leu Ser Lys Val Ala Pro Val Glu Trp Arg Lys Gly Pro
            1540                1545                1550        
Glu Thr Leu Arg Asp Gly Asp Arg His Ser Leu Arg Gln Glu Asn Arg
        1555                1560                1565            
Leu Asn Pro Gly Gly Gly Gly Cys Ser Glu Leu Gly Ser Cys His Cys
    1570                1575                1580                
Ser Pro Ala Trp Thr Ala Lys Leu Asp Phe Ile Ser
1585                1590                1595    


<210> 993
<211> 544
<212> PRT
<213> Homo sapiens

<400> 993
Lys Gly Leu Thr Ser Phe Cys Ser Ser Lys Thr Met Ala His Gly Ser
 1               5                  10                  15      
Val Thr Phe Arg Asp Val Ala Ile Asp Phe Ser Gln Glu Glu Trp Glu
            20                  25                  30          
Phe Leu Asp Pro Ala Gln Arg Asp Leu Tyr Arg Asp Val Met Trp Glu
        35                  40                  45              
Asn Tyr Ser Asn Phe Ile Ser Leu Gly Pro Ser Ile Ser Lys Pro Asp
    50                  55                  60                  
Val Ile Thr Leu Leu Asp Glu Glu Arg Lys Glu Pro Gly Met Val Val
65                  70                  75                  80  
Arg Glu Gly Thr Arg Arg Tyr Cys Pro Asp Leu Glu Ser Arg Tyr Arg
                85                  90                  95      
Thr Asn Thr Leu Ser Pro Glu Lys Asp Ile Tyr Glu Ile Tyr Ser Phe
            100                 105                 110         
Gln Trp Asp Ile Met Glu Arg Ile Lys Ser Tyr Ser Leu Gln Gly Ser
        115                 120                 125             
Ile Phe Arg Asn Asp Trp Glu Cys Lys Ser Lys Ile Glu Gly Glu Lys
    130                 135                 140                 
Glu Gln Gln Glu Gly Tyr Phe Gly Gln Val Lys Ile Thr Ser Glu Lys
145                 150                 155                 160 
Met Thr Thr Tyr Lys Arg His Asn Phe Leu Thr Glu Tyr Gln Ile Val
                165                 170                 175     
His Asn Gly Glu Lys Val Tyr Glu Cys Lys Glu Cys Arg Lys Thr Phe
            180                 185                 190         
Ile Arg Arg Ser Thr Leu Ser Gln His Leu Arg Ile His Thr Gly Glu
        195                 200                 205             
Lys Pro Tyr Lys Cys Lys Glu Cys Gly Gln Ala Phe Arg Gln Arg Ala
    210                 215                 220                 
His Leu Ile Arg His His Lys Leu His Thr Gly Glu Lys Pro Tyr Glu
225                 230                 235                 240 
Cys Lys Glu Cys Gly Lys Ala Phe Thr Val Leu Gln Glu Leu Thr Gln
                245                 250                 255     
His Gln Arg Leu His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys
            260                 265                 270         
Gly Lys Ala Phe Arg Val His Gln Gln Leu Ala Arg His Gln Arg Ile
        275                 280                 285             
His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Asp Cys Gly Lys Thr Phe
    290                 295                 300                 
Arg Gln Cys Thr His Leu Thr Arg His Gln Arg Leu His Thr Ala Glu
305                 310                 315                 320 
Lys Leu Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Val Cys Gly Pro
                325                 330                 335     
Asp Leu Arg Val His Gln Lys Ile His Phe Gly Glu Lys Pro Tyr Glu
            340                 345                 350         
Cys Lys Glu Cys Gly Lys Ala Phe Arg Ile Cys Gln Gln Leu Thr Val
        355                 360                 365             
His Gln Ser Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys
    370                 375                 380                 
Gly Lys Thr Phe Arg Leu Arg Gln Gln Leu Val Arg His Gln Arg Ile
385                 390                 395                 400 
His Thr Arg Glu Lys Pro Tyr Glu Cys Met Glu Cys Trp Lys Thr Phe
                405                 410                 415     
Ser Ser Tyr Ser Gln Leu Ile Ser His Gln Ser Ile His Ile Gly Glu
            420                 425                 430         
Arg Pro Tyr Glu Cys Glu Glu Cys Gly Lys Ala Phe Arg Leu Leu Ser
        435                 440                 445             
Gln Leu Thr Gln His Gln Ser Ile His Thr Gly Glu Lys Pro Tyr Glu
    450                 455                 460                 
Cys Lys Glu Cys Arg Lys Pro Phe Arg Leu Leu Ser Gln Leu Thr Gln
465                 470                 475                 480 
His Gln Ser Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys
                485                 490                 495     
Gly Lys Ala Phe Arg Leu Tyr Ser Phe Leu Thr Gln His Gln Arg Ile
            500                 505                 510         
His Thr Gly Glu Lys Pro Tyr Lys Cys Lys Glu Cys Lys Lys Ala Phe
        515                 520                 525             
Arg Gln His Ser His Leu Thr Gln His Gln Lys Ile His Asn Gly Ile
    530                 535                 540                 


<210> 994
<211> 1151
<212> PRT
<213> Homo sapiens

<400> 994
Pro Val Phe Ser Tyr Val Leu Pro Lys Arg Asn Leu Thr His Met Gln
 1               5                  10                  15      
Asp Glu Val Asn Val Lys Ser His Gln Arg Glu His Gln Asn Ile Gln
            20                  25                  30          
Asp Leu Glu Ile Glu Asn Glu Asp Leu Lys Glu Arg Leu Arg Lys Ile
        35                  40                  45              
Gln Gln Glu Gln Arg Ile Leu Leu Asp Lys Val Asn Gly Leu Gln Leu
    50                  55                  60                  
Gln Leu Asn Glu Glu Val Met Val Ala Asp Asp Leu Glu Ser Glu Arg
65                  70                  75                  80  
Glu Lys Leu Lys Ser Leu Leu Ala Ala Lys Glu Lys Gln His Glu Glu
                85                  90                  95      
Ser Leu Arg Thr Ile Glu Ala Leu Lys Asn Arg Phe Lys Tyr Phe Glu
            100                 105                 110         
Ser Asp His Leu Gly Ser Gly Ser His Phe Ser Asn Arg Lys Glu Asp
        115                 120                 125             
Met Leu Leu Lys Gln Gly Gln Met Tyr Met Ala Asp Ser Gln Cys Thr
    130                 135                 140                 
Ser Pro Gly Ile Pro Ala His Met Gln Ser Arg Ser Met Leu Arg Pro
145                 150                 155                 160 
Leu Glu Leu Ser Leu Pro Ser Gln Thr Ser Tyr Ser Glu Asn Glu Ile
                165                 170                 175     
Leu Lys Lys Glu Leu Glu Ala Met Arg Thr Phe Cys Glu Ser Ala Lys
            180                 185                 190         
Gln Asp Arg Leu Lys Leu Gln Asn Glu Leu Ala His Lys Val Ala Glu
        195                 200                 205             
Cys Lys Ala Leu Ala Leu Glu Cys Glu Arg Val Lys Glu Asp Ser Asp
    210                 215                 220                 
Glu Gln Ile Lys Gln Leu Glu Asp Ala Leu Lys Asp Val Gln Lys Arg
225                 230                 235                 240 
Met Tyr Glu Ser Glu Gly Lys Val Lys Gln Met Gln Thr His Phe Leu
                245                 250                 255     
Ala Leu Lys Glu His Leu Thr Ser Glu Ala Ala Ser Gly Asn His Arg
            260                 265                 270         
Leu Thr Glu Glu Leu Lys Asp Gln Leu Lys Asp Leu Lys Val Lys Tyr
        275                 280                 285             
Glu Gly Ala Ser Ala Glu Val Gly Lys Leu Arg Asn Gln Ile Lys Gln
    290                 295                 300                 
Asn Glu Met Ile Val Glu Glu Phe Lys Arg Asp Glu Gly Lys Leu Ile
305                 310                 315                 320 
Glu Glu Asn Lys Arg Leu Gln Lys Glu Leu Ser Met Cys Glu Met Glu
                325                 330                 335     
Arg Glu Lys Lys Gly Arg Lys Val Thr Glu Met Glu Gly Gln Ala Lys
            340                 345                 350         
Glu Leu Ser Ala Lys Leu Ala Leu Ser Ile Pro Ala Glu Lys Phe Glu
        355                 360                 365             
Asn Met Lys Ser Ser Leu Ser Asn Glu Val Asn Glu Lys Ala Lys Lys
    370                 375                 380                 
Leu Val Glu Met Glu Arg Glu His Glu Lys Ser Leu Ser Glu Ile Arg
385                 390                 395                 400 
Gln Leu Lys Arg Glu Leu Glu Asn Val Lys Ala Lys Leu Ala Gln His
                405                 410                 415     
Val Lys Pro Glu Glu His Glu Gln Val Lys Ser Arg Leu Glu Gln Lys
            420                 425                 430         
Ser Gly Glu Leu Gly Lys Lys Ile Thr Glu Leu Thr Leu Lys Asn Gln
        435                 440                 445             
Thr Leu Gln Lys Glu Ile Glu Lys Val Tyr Leu Asp Asn Lys Leu Leu
    450                 455                 460                 
Lys Glu Gln Ala His Asn Leu Thr Ile Glu Met Lys Asn His Tyr Val
465                 470                 475                 480 
Pro Leu Lys Val Ser Glu Asp Met Lys Lys Ser His Asp Ala Ile Ile
                485                 490                 495     
Asp Asp Leu Asn Arg Lys Leu Leu Asp Val Thr Gln Lys Tyr Thr Glu
            500                 505                 510         
Lys Lys Leu Glu Met Glu Lys Leu Leu Leu Glu Asn Asp Ser Leu Ser
        515                 520                 525             
Lys Asp Val Ser Arg Leu Glu Thr Val Phe Val Pro Pro Glu Lys His
    530                 535                 540                 
Glu Lys Glu Ile Ile Ala Leu Lys Ser Asn Ile Val Glu Leu Lys Lys
545                 550                 555                 560 
Gln Leu Ser Glu Leu Lys Lys Lys Cys Gly Glu Asp Gln Glu Lys Ile
                565                 570                 575     
His Ala Leu Thr Ser Glu Asn Thr Asn Leu Lys Lys Met Met Ser Asn
            580                 585                 590         
Gln Tyr Val Pro Val Lys Thr His Glu Glu Val Lys Met Thr Leu Asn
        595                 600                 605             
Asp Thr Leu Ala Lys Thr Asn Arg Glu Leu Leu Asp Val Lys Lys Lys
    610                 615                 620                 
Phe Glu Asp Ile Asn Gln Glu Phe Val Lys Ile Lys Asp Lys Asn Glu
625                 630                 635                 640 
Ile Leu Lys Arg Asn Leu Glu Asn Thr Gln Asn Gln Ile Lys Ala Glu
                645                 650                 655     
Tyr Ile Ser Leu Ala Glu His Glu Ala Lys Met Ser Ser Leu Ser Gln
            660                 665                 670         
Ser Met Arg Lys Val Gln Asp Ser Asn Ala Glu Ile Leu Ala Asn Tyr
        675                 680                 685             
Arg Lys Gly Gln Glu Glu Ile Val Thr Leu His Ala Glu Ile Lys Ala
    690                 695                 700                 
Gln Lys Lys Glu Leu Asp Thr Ile Gln Glu Cys Ile Lys Val Lys Tyr
705                 710                 715                 720 
Ala Pro Ile Val Ser Phe Glu Glu Cys Glu Arg Lys Phe Lys Ala Thr
                725                 730                 735     
Glu Lys Glu Leu Lys Asp Gln Leu Ser Glu Gln Thr Gln Lys Tyr Ser
            740                 745                 750         
Val Ser Glu Glu Glu Val Lys Lys Asn Lys Gln Glu Asn Asp Lys Leu
        755                 760                 765             
Lys Lys Glu Ile Phe Thr Leu Gln Lys Asp Leu Arg Asp Lys Thr Val
    770                 775                 780                 
Leu Ile Glu Lys Ser His Glu Met Glu Arg Ala Leu Ser Arg Lys Thr
785                 790                 795                 800 
Asp Glu Leu Asn Lys Gln Leu Lys Asp Leu Ser Gln Lys Tyr Thr Glu
                805                 810                 815     
Val Lys Asn Val Lys Glu Lys Leu Val Glu Glu Asn Ala Lys Gln Thr
            820                 825                 830         
Ser Glu Ile Leu Ala Val Gln Asn Leu Leu Gln Lys Gln His Val Pro
        835                 840                 845             
Leu Glu Gln Val Glu Ala Leu Lys Lys Ser Leu Asn Gly Thr Ile Glu
    850                 855                 860                 
Asn Leu Lys Glu Glu Leu Lys Ser Met Gln Arg Cys Tyr Glu Lys Glu
865                 870                 875                 880 
Gln Gln Thr Val Thr Lys Leu His Gln Leu Leu Glu Asn Gln Lys Asn
                885                 890                 895     
Ser Ser Val Pro Leu Ala Glu His Leu Gln Ile Lys Glu Ala Phe Glu
            900                 905                 910         
Lys Glu Val Gly Ile Ile Lys Ala Ser Leu Arg Glu Lys Glu Glu Glu
        915                 920                 925             
Ser Gln Asn Lys Met Glu Glu Val Ser Lys Leu Gln Ser Glu Val Gln
    930                 935                 940                 
Asn Thr Lys Gln Ala Leu Lys Lys Leu Glu Thr Arg Glu Val Val Asp
945                 950                 955                 960 
Leu Ser Lys Tyr Lys Ala Thr Lys Ser Asp Leu Glu Thr Gln Ile Ser
                965                 970                 975     
Ser Leu Asn Glu Lys Leu Ala Asn Leu Asn Arg Lys Tyr Glu Glu Val
            980                 985                 990         
Cys Glu Glu Val Leu His Ala Lys Lys Lys Glu Ile Ser Ala Lys Asp
        995                 1000                1005            
Glu Lys Glu Leu Leu His Phe Ser Ile Glu Gln Glu Ile Lys Asp Gln
    1010                1015                1020                
Lys Glu Arg Cys Asp Lys Ser Leu Thr Thr Ile Thr Glu Leu Gln Arg
1025                1030                1035                1040
Arg Ile Gln Glu Ser Ala Lys Gln Ile Glu Ala Lys Asp Asn Lys Ile
                1045                1050                1055    
Thr Glu Leu Leu Asn Asp Val Glu Arg Leu Lys Gln Ala Leu Asn Gly
            1060                1065                1070        
Leu Ser Gln Leu Thr Tyr Thr Ser Gly Asn Pro Thr Lys Arg Gln Ser
        1075                1080                1085            
Gln Leu Ile Asp Thr Leu Gln His Gln Val Lys Ser Leu Glu Gln Gln
    1090                1095                1100                
Leu Ala Asp Ala Asp Arg Gln His Gln Glu Val Ile Ala Ile Tyr Arg
1105                1110                1115                1120
Thr His Leu Leu Ser Ala Ala Gln Gly His Met Asp Glu Asp Val Gln
                1125                1130                1135    
Glu Ala Leu Leu Gln Ile Ile Gln Met Arg Gln Gly Leu Val Cys
            1140                1145                1150    


<210> 995
<211> 924
<212> PRT
<213> Homo sapiens

<400> 995
Ser Arg Ser Arg Val Pro Val Pro Gly Pro Gly Ala Ala Ala Ala Pro
 1               5                  10                  15      
Cys Pro Ala Pro Ala Ser Pro Arg Arg His Pro Ser Ala Asn Ile Pro
            20                  25                  30          
Glu Ile Lys Arg Tyr Ala Ala Ala Ala Ala Ala Ala Ala Gly Pro Gly
        35                  40                  45              
Ala Gly Gly Ala Gly Asp Arg Gly Glu Ala Ala Pro Ala Ala Ala Met
    50                  55                  60                  
Glu Ala Leu Gly Pro Gly Pro Pro Ala Ser Leu Phe Gln Pro Pro Arg
65                  70                  75                  80  
Arg Pro Gly Leu Gly Thr Val Gly Lys Pro Ile Arg Leu Leu Ala Asn
                85                  90                  95      
His Phe Gln Val Gln Ile Pro Lys Ile Asp Val Tyr His Tyr Asp Val
            100                 105                 110         
Asp Ile Lys Pro Glu Lys Arg Pro Arg Arg Val Asn Arg Glu Val Val
        115                 120                 125             
Asp Thr Met Val Arg His Phe Lys Met Gln Ile Phe Gly Asp Arg Gln
    130                 135                 140                 
Pro Gly Tyr Asp Gly Lys Arg Asn Met Tyr Thr Ala His Pro Leu Pro
145                 150                 155                 160 
Ile Gly Arg Asp Arg Val Asp Met Glu Val Thr Leu Pro Gly Glu Gly
                165                 170                 175     
Lys Asp Gln Thr Phe Lys Val Ser Val Gln Trp Val Ser Val Val Ser
            180                 185                 190         
Leu Gln Leu Leu Leu Glu Ala Leu Ala Gly His Leu Asn Glu Val Pro
        195                 200                 205             
Asp Asp Ser Val Gln Ala Leu Asp Val Ile Thr Arg His Leu Pro Ser
    210                 215                 220                 
Met Arg Tyr Thr Pro Val Gly Arg Ser Phe Phe Ser Pro Pro Glu Gly
225                 230                 235                 240 
Tyr Tyr His Pro Leu Gly Gly Gly Arg Glu Val Trp Phe Gly Phe His
                245                 250                 255     
Gln Ser Val Arg Pro Ala Met Trp Asn Met Met Leu Asn Ile Asp Val
            260                 265                 270         
Ser Ala Thr Ala Phe Tyr Arg Ala Gln Pro Ile Ile Glu Phe Met Cys
        275                 280                 285             
Glu Val Leu Asp Ile Gln Asn Ile Asn Glu Gln Thr Lys Pro Leu Thr
    290                 295                 300                 
Asp Ser Gln Arg Val Lys Phe Thr Lys Glu Ile Arg Gly Leu Lys Val
305                 310                 315                 320 
Glu Val Thr His Cys Gly Gln Met Lys Arg Lys Tyr Arg Val Cys Asn
                325                 330                 335     
Val Thr Arg Arg Pro Ala Ser His Gln Thr Phe Pro Leu Gln Leu Glu
            340                 345                 350         
Asn Gly Gln Ala Met Glu Cys Thr Val Ala Gln Tyr Phe Lys Gln Lys
        355                 360                 365             
Tyr Ser Leu Gln Leu Lys Tyr Pro His Leu Pro Cys Leu Gln Val Gly
    370                 375                 380                 
Gln Glu Gln Lys His Thr Tyr Leu Pro Leu Glu Val Cys Asn Ile Val
385                 390                 395                 400 
Ala Gly Gln Arg Cys Ile Lys Lys Leu Thr Asp Asn Gln Thr Ser Thr
                405                 410                 415     
Met Ile Lys Ala Thr Ala Arg Ser Ala Pro Asp Arg Gln Glu Glu Ile
            420                 425                 430         
Ser Arg Leu Val Lys Ser Asn Ser Met Val Gly Gly Pro Asp Pro Tyr
        435                 440                 445             
Leu Lys Glu Phe Gly Ile Val Val His Asn Glu Met Thr Glu Leu Thr
    450                 455                 460                 
Gly Arg Val Leu Pro Ala Pro Met Leu Gln Tyr Gly Gly Arg Asn Lys
465                 470                 475                 480 
Thr Val Ala Thr Pro Asn Gln Gly Val Trp Asp Met Arg Gly Lys Gln
                485                 490                 495     
Phe Tyr Ala Gly Ile Glu Ile Lys Val Trp Ala Val Ala Cys Phe Ala
            500                 505                 510         
Pro Gln Lys Gln Cys Arg Glu Asp Leu Leu Lys Ser Phe Thr Asp Gln
        515                 520                 525             
Leu Arg Lys Ile Ser Lys Asp Ala Gly Met Pro Ile Gln Gly Gln Pro
    530                 535                 540                 
Cys Phe Cys Lys Tyr Ala Gln Gly Ala Asp Ser Val Glu Pro Met Phe
545                 550                 555                 560 
Lys His Leu Lys Met Thr Tyr Val Gly Leu Gln Leu Ile Val Val Ile
                565                 570                 575     
Leu Pro Gly Lys Thr Pro Val Tyr Ala Glu Val Lys Arg Val Gly Asp
            580                 585                 590         
Thr Leu Leu Gly Met Ala Thr Gln Cys Val Gln Val Lys Asn Val Val
        595                 600                 605             
Lys Thr Ser Pro Gln Thr Leu Ser Asn Leu Cys Leu Lys Ile Asn Ala
    610                 615                 620                 
Lys Leu Gly Gly Ile Asn Asn Val Leu Val Pro His Gln Arg Pro Ser
625                 630                 635                 640 
Val Phe Gln Gln Pro Val Ile Phe Leu Gly Ala Asp Val Thr His Pro
                645                 650                 655     
Pro Ala Gly Asp Gly Lys Lys Pro Ser Ile Ala Ala Val Val Gly Ser
            660                 665                 670         
Met Asp Gly His Pro Ser Arg Tyr Cys Ala Thr Val Arg Val Gln Thr
        675                 680                 685             
Ser Arg Gln Glu Ile Ser Gln Glu Leu Leu Tyr Ser Gln Glu Val Ile
    690                 695                 700                 
Gln Asp Leu Thr Asn Met Val Arg Glu Leu Leu Ile Gln Phe Tyr Lys
705                 710                 715                 720 
Ser Thr Arg Phe Lys Pro Thr Arg Ile Ile Tyr Tyr Arg Gly Gly Val
                725                 730                 735     
Ser Glu Gly Gln Met Lys Gln Val Ala Trp Pro Glu Leu Ile Ala Ile
            740                 745                 750         
Arg Lys Ala Cys Ile Ser Leu Glu Glu Asp Tyr Arg Pro Gly Ile Thr
        755                 760                 765             
Tyr Ile Val Val Gln Lys Arg His His Thr Arg Leu Phe Cys Ala Asp
    770                 775                 780                 
Lys Thr Glu Arg Val Gly Lys Ser Gly Asn Val Pro Ala Gly Thr Thr
785                 790                 795                 800 
Val Asp Ser Thr Ile Thr His Pro Ser Glu Phe Asp Phe Tyr Leu Cys
                805                 810                 815     
Ser His Ala Gly Ile Gln Gly Thr Ser Arg Pro Ser His Tyr Gln Val
            820                 825                 830         
Leu Trp Asp Asp Asn Cys Phe Thr Ala Asp Glu Leu Gln Leu Leu Thr
        835                 840                 845             
Tyr Gln Leu Cys His Thr Tyr Val Arg Cys Thr Arg Ser Val Ser Ile
    850                 855                 860                 
Pro Ala Pro Ala Tyr Tyr Ala Arg Leu Val Ala Phe Arg Ala Arg Tyr
865                 870                 875                 880 
His Leu Val Asp Lys Asp His Asp Ser Ala Glu Gly Ser His Val Ser
                885                 890                 895     
Gly Gln Ser Asn Gly Arg Asp Pro Gln Ala Leu Ala Lys Ala Val Gln
            900                 905                 910         
Ile His His Asp Thr Gln His Thr Met Tyr Phe Ala
        915                 920                 


<210> 996
<211> 670
<212> PRT
<213> Homo sapiens

<400> 996
Lys Gln Met Phe Gln Leu His Ile Gly Asn Val Tyr Glu Ala Gly Lys
 1               5                  10                  15      
Leu Asn Leu Leu Thr Val Ile Gln Leu Leu Asn Glu Val Leu Lys Val
            20                  25                  30          
Met Lys Tyr Glu Arg Cys Gln Ala Asp Gln Ala Arg Leu Thr Val Asp
        35                  40                  45              
Leu His Tyr Leu Glu Lys Glu Thr Lys Phe Gln Lys Glu Arg Leu Ser
    50                  55                  60                  
Asp Leu Lys His Met Arg Tyr Arg Ile Lys Asp Asp Leu Thr Thr Ile
65                  70                  75                  80  
Arg His Ser Val Val Glu Lys Gln Gly Glu Trp His Lys Lys Trp Lys
                85                  90                  95      
Glu Phe Leu Gly Leu Ser Pro Phe Ser Leu Ile Lys Gly Trp Thr Pro
            100                 105                 110         
Ser Val Asp Leu Leu Pro Pro Met Ser Pro Leu Ser Phe Asp Pro Ala
        115                 120                 125             
Ser Glu Glu Val Tyr Ala Lys Ser Ile Leu Cys Gln Tyr Pro Ala Ser
    130                 135                 140                 
Leu Pro Asp Ala His Lys Gln His Asn Gln Glu Asn Gly Cys Arg Gly
145                 150                 155                 160 
Asp Ser Asp Thr Leu Gly Ala Leu His Asp Leu Ala Asn Ser Pro Ala
                165                 170                 175     
Ser Phe Leu Ser Gln Ser Val Ser Ser Ser Asp Arg Asn Ser Val Thr
            180                 185                 190         
Val Leu Glu Lys Asp Thr Lys Met Gly Thr Pro Lys Glu Lys Asn Glu
        195                 200                 205             
Ala Ile Ser Lys Lys Ile Pro Glu Phe Glu Val Glu Asn Ser Pro Leu
    210                 215                 220                 
Ser Asp Val Ala Lys Asn Thr Glu Ser Ser Ala Phe Gly Gly Ser Leu
225                 230                 235                 240 
Pro Ala Lys Lys Ser Asp Pro Phe Gln Lys Glu Gln Asp His Leu Val
                245                 250                 255     
Glu Glu Val Ala Arg Ala Val Leu Ser Asp Ser Pro Gln Leu Ser Glu
            260                 265                 270         
Gly Lys Glu Ile Lys Leu Glu Glu Leu Ile Asp Ser Leu Gly Ser Asn
        275                 280                 285             
Pro Phe Leu Thr Arg Asn Gln Ile Pro Arg Thr Pro Glu Asn Leu Ile
    290                 295                 300                 
Thr Glu Ile Arg Ser Ser Trp Arg Lys Ala Ile Glu Met Glu Glu Asn
305                 310                 315                 320 
Arg Thr Lys Glu Pro Ile Gln Met Asp Ala Glu His Arg Glu Val Leu
                325                 330                 335     
Pro Glu Ser Leu Pro Val Leu His Asn Gln Arg Glu Phe Ser Met Ala
            340                 345                 350         
Asp Phe Leu Leu Glu Thr Thr Val Ser Asp Phe Gly Gln Ser His Leu
        355                 360                 365             
Thr Glu Glu Lys Val Ile Ser Asp Cys Glu Cys Val Pro Gln Lys His
    370                 375                 380                 
Val Leu Thr Ser His Ile Asp Glu Pro Pro Thr Gln Asn Gln Ser Asp
385                 390                 395                 400 
Leu Leu Asn Lys Lys Val Ile Cys Lys Gln Asp Leu Glu Cys Leu Ala
                405                 410                 415     
Phe Thr Lys Leu Ser Glu Thr Ser Arg Met Glu Thr Phe Ser Pro Ala
            420                 425                 430         
Val Gly Asn Arg Ile Asp Val Met Gly Gly Ser Glu Glu Glu Phe Met
        435                 440                 445             
Lys Ile Leu Asp His Leu Glu Val Ser Cys Asn Lys Pro Ser Thr Asn
    450                 455                 460                 
Lys Thr Met Leu Trp Asn Ser Phe Gln Ile Ser Ser Gly Ile Ser Ser
465                 470                 475                 480 
Lys Ser Phe Lys Asp Asn Asp Phe Gly Ile Leu His Glu Thr Leu Pro
                485                 490                 495     
Glu Glu Val Gly His Leu Ser Phe Asn Ser Ser Ser Ser Ser Glu Ala
            500                 505                 510         
Asn Phe Lys Leu Glu Pro Asn Ser Pro Met His Gly Gly Thr Leu Leu
        515                 520                 525             
Glu Asp Val Val Gly Gly Arg Gln Thr Thr Pro Glu Ser Asp Phe Asn
    530                 535                 540                 
Leu Gln Ala Leu Arg Ser Arg Tyr Glu Ala Leu Lys Lys Ser Leu Ser
545                 550                 555                 560 
Lys Lys Arg Glu Glu Ser Tyr Leu Ser Asn Ser Gln Thr Pro Glu Arg
                565                 570                 575     
His Lys Pro Glu Leu Ser Pro Thr Pro Gln Asn Val Gln Thr Asp Asp
            580                 585                 590         
Thr Leu Asn Phe Leu Asp Thr Cys Asp Leu His Thr Glu His Ile Lys
        595                 600                 605             
Pro Ser Leu Arg Thr Ser Ile Gly Glu Arg Lys Arg Ser Leu Ser Pro
    610                 615                 620                 
Leu Ile Lys Phe Ser Pro Val Glu Gln Arg Leu Arg Thr Thr Ile Ala
625                 630                 635                 640 
Cys Ser Leu Gly Glu Leu Pro Asn Leu Lys Glu Glu Asp Ile Leu Asn
                645                 650                 655     
Lys Ser Leu Asp Ala Lys Glu Pro Pro Ser Asp Leu Thr Arg
            660                 665                 670 


<210> 997
<211> 1202
<212> PRT
<213> Homo sapiens

<400> 997
Gln Lys Ala Ala Phe Thr Cys Ile Lys Asn Leu Trp Asn Arg Lys Pro
 1               5                  10                  15      
Leu Lys Val Tyr Gly Gly Arg Met Ala Glu Ser Met Leu Ala Ile Leu
            20                  25                  30          
Cys His Ile Leu Arg Gly Glu Pro Val Ile Arg Glu Arg Leu Ser Lys
        35                  40                  45              
Glu Lys Glu Gly Ser Arg Gly Glu Glu Asp Thr Gly Gln Glu Glu Gly
    50                  55                  60                  
Gly Ser Arg Arg Glu Pro Gln Val Asn Gln Gln Gln Leu Gln Gln Leu
65                  70                  75                  80  
Met Asp Met Gly Phe Thr Arg Glu His Ala Met Glu Ala Leu Leu Asn
                85                  90                  95      
Thr Ser Thr Met Glu Gln Ala Thr Glu Tyr Leu Leu Thr His Pro Pro
            100                 105                 110         
Pro Ile Met Gly Gly Val Val Arg Asp Leu Ser Met Ser Glu Glu Asp
        115                 120                 125             
Gln Met Met Arg Ala Ile Ala Met Ser Leu Gly Gln Asp Ile Pro Met
    130                 135                 140                 
Asp Gln Arg Ala Glu Ser Pro Glu Glu Val Ala Cys Arg Lys Glu Glu
145                 150                 155                 160 
Glu Glu Arg Lys Ala Arg Glu Lys Gln Glu Glu Glu Glu Ala Lys Cys
                165                 170                 175     
Leu Glu Lys Phe Gln Asp Ala Asp Pro Leu Glu Gln Asp Glu Leu His
            180                 185                 190         
Thr Phe Thr Asp Thr Met Leu Pro Gly Cys Phe His Leu Leu Asp Glu
        195                 200                 205             
Leu Pro Asp Thr Val Tyr Arg Val Cys Asp Leu Ile Met Thr Ala Ile
    210                 215                 220                 
Lys Arg Asn Gly Ala Asp Tyr Arg Asp Met Ile Leu Lys Gln Val Val
225                 230                 235                 240 
Asn Gln Val Trp Glu Ala Ala Asp Val Leu Ile Lys Ala Ala Leu Pro
                245                 250                 255     
Leu Thr Thr Ser Asp Thr Lys Thr Val Ser Glu Trp Ile Ser Gln Met
            260                 265                 270         
Ala Thr Leu Pro Gln Ala Ser Asn Leu Ala Thr Arg Ile Leu Leu Leu
        275                 280                 285             
Thr Leu Leu Phe Glu Glu Leu Lys Leu Pro Cys Ala Trp Val Val Glu
    290                 295                 300                 
Ser Ser Gly Ile Leu Asn Val Leu Ile Lys Leu Leu Glu Val Val Gln
305                 310                 315                 320 
Pro Cys Leu Gln Ala Ala Lys Glu Gln Lys Glu Val Gln Thr Pro Lys
                325                 330                 335     
Trp Ile Thr Pro Val Leu Leu Leu Ile Asp Phe Tyr Glu Lys Thr Ala
            340                 345                 350         
Ile Ser Ser Lys Arg Arg Ala Gln Met Thr Lys Tyr Leu Gln Ser Asn
        355                 360                 365             
Ser Asn Asn Trp Arg Trp Phe Asp Asp Arg Ser Gly Arg Trp Cys Ser
    370                 375                 380                 
Tyr Ser Ala Ser Asn Asn Ser Thr Ile Asp Ser Ala Trp Lys Ser Gly
385                 390                 395                 400 
Glu Thr Ser Val Arg Phe Thr Ala Gly Arg Arg Arg Tyr Thr Val Gln
                405                 410                 415     
Phe Thr Thr Met Val Gln Val Asn Glu Glu Thr Gly Asn Arg Arg Pro
            420                 425                 430         
Val Met Leu Thr Leu Leu Arg Val Pro Arg Leu Asn Lys Asn Ser Lys
        435                 440                 445             
Asn Ser Asn Gly Gln Glu Leu Glu Lys Thr Leu Glu Glu Ser Lys Glu
    450                 455                 460                 
Met Asp Ile Lys Arg Lys Glu Asn Lys Gly Asn Asp Thr Pro Leu Ala
465                 470                 475                 480 
Leu Glu Ser Thr Asn Thr Glu Lys Glu Thr Ser Leu Glu Glu Thr Lys
                485                 490                 495     
Ile Gly Glu Ile Leu Ile Gln Gly Leu Thr Glu Asp Met Val Thr Val
            500                 505                 510         
Leu Ile Arg Ala Cys Val Ser Met Leu Gly Val Pro Val Asp Pro Asp
        515                 520                 525             
Thr Leu His Ala Thr Leu Arg Leu Cys Leu Arg Leu Thr Arg Asp His
    530                 535                 540                 
Lys Tyr Ala Met Met Phe Ala Glu Leu Lys Ser Thr Arg Met Ile Leu
545                 550                 555                 560 
Asn Leu Thr Gln Ser Ser Gly Phe Asn Gly Phe Thr Pro Leu Val Thr
                565                 570                 575     
Leu Leu Leu Arg His Ile Ile Glu Asp Pro Cys Thr Leu Arg His Thr
            580                 585                 590         
Met Glu Lys Val Val Arg Ser Ala Ala Thr Ser Gly Ala Gly Ser Thr
        595                 600                 605             
Thr Ser Gly Val Val Ser Gly Ser Leu Gly Ser Arg Glu Ile Asn Tyr
    610                 615                 620                 
Ile Leu Arg Val Leu Gly Pro Ala Ala Cys Arg Asn Pro Asp Ile Phe
625                 630                 635                 640 
Thr Glu Val Ala Asn Cys Cys Ile Arg Ile Ala Leu Pro Ala Pro Arg
                645                 650                 655     
Gly Ser Gly Thr Ala Ser Asp Asp Glu Phe Glu Asn Leu Arg Ile Lys
            660                 665                 670         
Gly Pro Asn Ala Val Gln Leu Val Lys Thr Thr Pro Leu Lys Pro Ser
        675                 680                 685             
Pro Leu Pro Val Ile Pro Asp Thr Ile Lys Glu Val Ile Tyr Asp Met
    690                 695                 700                 
Leu Asn Ala Leu Ala Ala Tyr His Ala Pro Glu Glu Ala Asp Lys Ser
705                 710                 715                 720 
Asp Pro Lys Pro Gly Val Met Thr Gln Glu Val Gly Gln Leu Leu Gln
                725                 730                 735     
Asp Met Gly Asp Asp Val Tyr Gln Gln Tyr Arg Ser Leu Thr Arg Gln
            740                 745                 750         
Ser Ser Asp Phe Asp Thr Gln Ser Gly Phe Ser Ile Asn Ser Gln Val
        755                 760                 765             
Phe Ala Ala Asp Gly Ala Ser Thr Glu Thr Ser Ala Ser Gly Thr Ser
    770                 775                 780                 
Gln Gly Glu Ala Ser Thr Pro Glu Glu Ser Arg Asp Gly Lys Lys Asp
785                 790                 795                 800 
Lys Glu Gly Asp Arg Ala Ser Glu Glu Gly Lys Gln Lys Gly Lys Gly
                805                 810                 815     
Ser Lys Pro Leu Met Pro Thr Ser Thr Ile Leu Arg Leu Leu Ala Glu
            820                 825                 830         
Leu Val Arg Ser Tyr Val Gly Ile Ala Thr Leu Ile Ala Asn Tyr Ser
        835                 840                 845             
Tyr Thr Val Gly Gln Ser Glu Leu Ile Lys Glu Asp Cys Ser Val Leu
    850                 855                 860                 
Ala Phe Val Leu Asp His Leu Leu Pro His Thr Gln Asn Ala Glu Asp
865                 870                 875                 880 
Lys Asp Thr Pro Ala Leu Ala Arg Leu Phe Leu Ala Ser Leu Ala Ala
                885                 890                 895     
Ala Gly Ser Gly Thr Asp Ala Gln Val Ala Leu Val Asn Glu Val Lys
            900                 905                 910         
Ala Ala Leu Gly Arg Ala Leu Ala Met Ala Glu Ser Thr Glu Lys His
        915                 920                 925             
Ala Arg Leu Gln Ala Val Met Cys Ile Ile Ser Thr Ile Met Glu Ser
    930                 935                 940                 
Cys Pro Ser Thr Ser Ser Phe Tyr Ser Ser Ala Thr Ala Lys Thr Gln
945                 950                 955                 960 
His Asn Gly Met Asn Asn Ile Ile Arg Leu Phe Leu Lys Lys Gly Leu
                965                 970                 975     
Val Asn Asp Leu Ala Arg Val Pro His Ser Leu Asp Leu Ser Ser Pro
            980                 985                 990         
Asn Met Ala Asn Thr Val Asn Ala Ala Leu Lys Pro Leu Glu Thr Leu
        995                 1000                1005            
Ser Arg Ile Val Asn Gln Pro Ser Ser Leu Phe Gly Ser Lys Ser Ala
    1010                1015                1020                
Ser Ser Lys Asn Lys Ser Glu Gln Asp Ala Gln Gly Ala Ser Gln Asp
1025                1030                1035                1040
Ser Ser Ser Asn Gln Gln Asp Pro Gly Glu Pro Gly Glu Ala Glu Val
                1045                1050                1055    
Gln Glu Glu Asp His Asp Val Thr Gln Thr Glu Val Ala Asp Gly Asp
            1060                1065                1070        
Ile Met Asp Gly Glu Ala Glu Thr Asp Ser Val Val Ile Ala Gly Gln
        1075                1080                1085            
Pro Glu Val Leu Ser Ser Gln Glu Met Gln Val Glu Asn Glu Leu Glu
    1090                1095                1100                
Asp Leu Ile Asp Glu Leu Leu Glu Arg Asp Gly Gly Ser Gly Asn Ser
1105                1110                1115                1120
Thr Ile Ile Val Ser Arg Ser Gly Glu Asp Glu Ser Gln Glu Asp Val
                1125                1130                1135    
Leu Met Asp Glu Ala Pro Ser Asn Leu Ser Gln Ala Ser Thr Leu Gln
            1140                1145                1150        
Ala Asn Arg Glu Asp Ser Met Asn Ile Leu Asp Pro Glu Asp Glu Glu
        1155                1160                1165            
Glu His Thr Gln Glu Arg Arg Ile Ala Ala Glu Glu Lys Lys Lys Gln
    1170                1175                1180                
Asp Glu Leu Lys Arg Ile Ala Arg Glu Leu Ala Glu Asp Asp Ser Ile
1185                1190                1195                1200
Leu Lys
        


<210> 998
<211> 1448
<212> PRT
<213> Homo sapiens

<400> 998
Gly Ile Ser Asn Ser Val Trp Gly Leu Ser Pro Gly Asn Pro Ala Thr
 1               5                  10                  15      
Gly Asn Ser Asn Ser Gly Phe Ser Gln Gly Asn Gly Asp Thr Val Asn
            20                  25                  30          
Ser Ala Leu Ser Ala Lys Gln Asn Gly Ser Ser Ser Ala Val Gln Lys
        35                  40                  45              
Glu Gly Ser Gly Gly Asn Ala Trp Asp Ser Gly Pro Pro Ala Gly Pro
    50                  55                  60                  
Gly Ile Leu Ala Trp Gly Arg Gly Ser Gly Asn Asn Gly Val Gly Asn
65                  70                  75                  80  
Ile His Ser Gly Ala Trp Gly His Pro Ser Arg Ser Thr Ser Asn Gly
                85                  90                  95      
Val Asn Gly Glu Trp Gly Lys Pro Pro Asn Gln His Ser Asn Ser Asp
            100                 105                 110         
Ile Asn Gly Lys Gly Ser Thr Gly Trp Glu Ser Pro Ser Val Thr Ser
        115                 120                 125             
Gln Asn Pro Thr Val Gln Pro Gly Gly Glu His Met Asn Ser Trp Ala
    130                 135                 140                 
Lys Ala Ala Ser Ser Gly Thr Thr Ala Ser Glu Gly Ser Ser Asp Gly
145                 150                 155                 160 
Ser Gly Asn His Asn Glu Gly Ser Thr Gly Arg Glu Gly Thr Gly Glu
                165                 170                 175     
Gly Arg Arg Arg Asp Lys Gly Ile Ile Asp Gln Gly His Ile Gln Leu
            180                 185                 190         
Pro Arg Asn Asp Leu Asp Pro Arg Val Leu Ser Asn Thr Gly Trp Gly
        195                 200                 205             
Gln Thr Pro Val Lys Gln Asn Thr Ala Trp Glu Phe Glu Glu Ser Pro
    210                 215                 220                 
Arg Ser Glu Arg Lys Asn Asp Asn Gly Thr Glu Ala Trp Gly Cys Ala
225                 230                 235                 240 
Ala Thr Gln Ala Ser Asn Ser Gly Gly Lys Asn Asp Gly Ser Ile Met
                245                 250                 255     
Asn Ser Thr Asn Thr Ser Ser Val Ser Gly Trp Val Asn Ala Pro Pro
            260                 265                 270         
Ala Ala Val Pro Ala Asn Thr Gly Trp Gly Asp Ser Asn Asn Lys Ala
        275                 280                 285             
Pro Ser Gly Pro Gly Val Trp Gly Asp Ser Ile Ser Ser Thr Ala Val
    290                 295                 300                 
Ser Thr Ala Ala Ala Ala Lys Ser Gly His Ala Trp Ser Gly Ala Ala
305                 310                 315                 320 
Asn Gln Glu Asp Lys Ser Pro Thr Trp Gly Glu Pro Pro Lys Pro Lys
                325                 330                 335     
Ser Gln His Trp Gly Asp Gly Gln Arg Ser Asn Pro Ala Trp Ser Ala
            340                 345                 350         
Gly Gly Gly Asp Trp Ala Asp Ser Ser Ser Val Leu Gly His Leu Gly
        355                 360                 365             
Asp Gly Lys Lys Asn Gly Ser Gly Trp Asp Ala Asp Ser Asn Arg Ser
    370                 375                 380                 
Gly Ser Gly Trp Asn Asp Thr Thr Arg Ser Gly Asn Ser Gly Trp Gly
385                 390                 395                 400 
Asn Ser Thr Asn Thr Lys Ala Asn Pro Gly Thr Asn Trp Gly Glu Thr
                405                 410                 415     
Leu Lys Pro Gly Pro Gln Gln Asn Trp Ala Ser Lys Pro Gln Asp Asn
            420                 425                 430         
Asn Val Ser Asn Trp Gly Gly Ala Ala Ser Val Lys Gln Thr Gly Thr
        435                 440                 445             
Gly Trp Ile Gly Gly Pro Val Pro Val Lys Gln Lys Asp Ser Ser Glu
    450                 455                 460                 
Ala Thr Gly Trp Glu Glu Pro Ser Pro Pro Ser Ile Arg Arg Lys Met
465                 470                 475                 480 
Glu Ile Asp Asp Gly Thr Ser Ala Trp Gly Asp Pro Ser Asn Tyr Asn
                485                 490                 495     
Asn Lys Thr Val Asn Met Trp Asp Arg Asn Asn Pro Val Ile Gln Ser
            500                 505                 510         
Ser Thr Thr Thr Asn Thr Thr Thr Thr Thr Thr Thr Thr Thr Ser Asn
        515                 520                 525             
Thr Thr His Arg Val Glu Thr Pro Pro Pro His Gln Ala Gly Thr Gln
    530                 535                 540                 
Leu Asn Arg Ser Pro Leu Leu Gly Pro Gly Arg Lys Val Ser Ser Gly
545                 550                 555                 560 
Trp Gly Glu Met Pro Asn Val His Ser Lys Thr Glu Asn Ser Trp Gly
                565                 570                 575     
Glu Pro Ser Ser Pro Ser Thr Leu Val Asp Asn Gly Thr Ala Ala Trp
            580                 585                 590         
Gly Lys Pro Pro Ser Ser Gly Ser Gly Trp Gly Asp His Pro Ala Glu
        595                 600                 605             
Pro Pro Val Ala Phe Gly Arg Ala Gly Ala Pro Val Ala Ala Ser Ala
    610                 615                 620                 
Leu Cys Lys Pro Ala Ser Lys Ser Met Gln Glu Gly Trp Gly Ser Gly
625                 630                 635                 640 
Gly Asp Glu Met Asn Leu Ser Thr Ser Gln Trp Glu Asp Glu Glu Gly
                645                 650                 655     
Asp Val Trp Asn Asn Ala Ala Ser Gln Glu Ser Thr Ser Ser Cys Ser
            660                 665                 670         
Ser Trp Gly Asn Ala Pro Lys Lys Gly Leu Gln Lys Gly Met Lys Thr
        675                 680                 685             
Ser Gly Lys Gln Asp Glu Ala Trp Ile Met Ser Arg Leu Ile Lys Gln
    690                 695                 700                 
Leu Thr Asp Met Gly Phe Pro Arg Glu Pro Ala Glu Glu Ala Leu Lys
705                 710                 715                 720 
Ser Asn Asn Met Asn Leu Asp Gln Ala Met Ser Ala Leu Leu Glu Lys
                725                 730                 735     
Lys Val Asp Val Asp Lys Arg Gly Leu Gly Val Thr Asp His Asn Gly
            740                 745                 750         
Met Ala Ala Lys Pro Leu Gly Cys Arg Pro Pro Ile Ser Lys Glu Ser
        755                 760                 765             
Ser Val Asp Arg Pro Thr Phe Leu Asp Lys Asp Gly Gly Leu Val Glu
    770                 775                 780                 
Glu Pro Thr Pro Ser Pro Phe Leu Pro Ser Pro Ser Leu Lys Leu Pro
785                 790                 795                 800 
Leu Ser His Ser Ala Leu Pro Ser Gln Ala Leu Gly Gly Ile Ala Ser
                805                 810                 815     
Gly Leu Gly Met Gln Asn Leu Asn Ser Ser Arg Gln Ile Pro Ser Gly
            820                 825                 830         
Asn Leu Gly Met Phe Gly Asn Ser Gly Ala Ala Gln Ala Arg Thr Met
        835                 840                 845             
Gln Gln Pro Pro Gln Pro Pro Val Gln Pro Leu Asn Ser Ser Gln Pro
    850                 855                 860                 
Ser Leu Arg Ala Gln Val Pro Gln Phe Leu Ser Pro Gln Val Gln Ala
865                 870                 875                 880 
Gln Leu Leu Gln Phe Ala Ala Lys Asn Ile Gly Leu Asn Pro Ala Leu
                885                 890                 895     
Leu Thr Ser Pro Ile Asn Pro Gln His Met Thr Met Leu Asn Gln Leu
            900                 905                 910         
Tyr Gln Leu Gln Leu Ala Tyr Gln Arg Leu Gln Ile Gln Gln Gln Met
        915                 920                 925             
Leu Gln Ala Gln Arg Asn Val Ser Gly Ser Met Arg Gln Gln Glu Gln
    930                 935                 940                 
Gln Val Ala Arg Thr Ile Thr Asn Leu Gln Gln Gln Ile Gln Gln His
945                 950                 955                 960 
Gln Arg Gln Leu Ala Gln Ala Leu Leu Val Lys Gln Pro Pro Pro Pro
                965                 970                 975     
Pro Pro Pro Pro His Leu Ser Leu His Pro Ser Ala Gly Lys Ser Ala
            980                 985                 990         
Met Asp Ser Phe Pro Ser His Pro Gln Thr Pro Gly Leu Pro Asp Leu
        995                 1000                1005            
Gln Thr Lys Glu Gln Gln Ser Ser Pro Asn Thr Phe Ala Pro Tyr Pro
    1010                1015                1020                
Leu Ala Gly Leu Asn Pro Asn Met Asn Val Asn Ser Met Asp Met Thr
1025                1030                1035                1040
Gly Gly Leu Ser Val Lys Asp Pro Ser Gln Ser Gln Ser Arg Leu Pro
                1045                1050                1055    
Gln Trp Thr His Pro Asn Ser Met Asp Asn Leu Pro Ser Ala Ala Ser
            1060                1065                1070        
Pro Leu Glu Gln Asn Pro Ser Lys His Gly Ala Ile Pro Gly Gly Leu
        1075                1080                1085            
Ser Ile Gly Pro Pro Gly Lys Ser Ser Ile Asp Asp Ser Tyr Gly Arg
    1090                1095                1100                
Tyr Asp Leu Ile Gln Asn Ser Glu Ser Pro Ala Ser Pro Pro Val Ala
1105                1110                1115                1120
Val Pro His Ser Trp Ser Arg Ala Lys Ser Asp Ser Asp Lys Ile Ser
                1125                1130                1135    
Asn Gly Ser Ser Ile Asn Trp Pro Pro Glu Phe His Pro Gly Val Pro
            1140                1145                1150        
Trp Lys Gly Leu Gln Asn Ile Asp Pro Glu Asn Asp Pro Asp Val Thr
        1155                1160                1165            
Pro Gly Ser Val Pro Thr Gly Pro Thr Ile Asn Thr Thr Ile Gln Asp
    1170                1175                1180                
Val Asn Arg Tyr Leu Leu Lys Ser Gly Gly Lys Leu Ser Asp Ile Lys
1185                1190                1195                1200
Ser Thr Trp Ser Ser Gly Pro Thr Ser His Thr Gln Ala Ser Leu Ser
                1205                1210                1215    
His Glu Leu Trp Lys Val Pro Arg Asn Ser Thr Ala Pro Thr Arg Pro
            1220                1225                1230        
Pro Pro Gly Leu Thr Asn Pro Lys Pro Ser Ser Thr Trp Gly Ala Ser
        1235                1240                1245            
Pro Leu Gly Trp Thr Ser Ser Tyr Ser Ser Gly Ser Ala Trp Ser Thr
    1250                1255                1260                
Asp Thr Ser Gly Arg Thr Ser Ser Trp Leu Val Leu Arg Asn Leu Thr
1265                1270                1275                1280
Pro Gln Ile Asp Gly Ser Thr Leu Arg Thr Leu Cys Leu Gln His Gly
                1285                1290                1295    
Pro Leu Ile Thr Phe His Leu Asn Leu Thr Gln Gly Asn Ala Val Val
            1300                1305                1310        
Arg Tyr Ser Ser Lys Glu Glu Ala Ala Lys Ala Gln Lys Ser Leu His
        1315                1320                1325            
Met Cys Val Leu Gly Asn Thr Thr Ile Leu Ala Glu Phe Ala Gly Glu
    1330                1335                1340                
Glu Glu Val Asn Arg Phe Leu Ala Gln Gly Gln Ala Leu Pro Pro Thr
1345                1350                1355                1360
Ser Ser Trp Gln Ser Ser Ser Ala Ser Ser Gln Pro Arg Leu Ser Ala
                1365                1370                1375    
Ala Gly Ser Ser His Gly Leu Val Arg Ser Asp Ala Gly His Trp Asn
            1380                1385                1390        
Ala Pro Cys Leu Gly Gly Lys Gly Ser Ser Glu Leu Leu Trp Gly Gly
        1395                1400                1405            
Val Pro Gln Tyr Ser Ser Ser Leu Trp Gly Pro Pro Ser Ala Asp Asp
    1410                1415                1420                
Ser Arg Val Ile Gly Ser Pro Thr Pro Leu Thr Thr Leu Leu Pro Gly
1425                1430                1435                1440
Asp Leu Leu Ser Gly Glu Ser Leu
                1445            


<210> 999
<211> 995
<212> PRT
<213> Homo sapiens

<400> 999
Gly Ser Ser Gln Ala Asp Pro Leu Arg Ser Arg Lys Glu Asn Arg Asn
 1               5                  10                  15      
Asn Leu Leu Ala Cys Leu Glu Ser His Gly Asn Ser Lys Met Ala Glu
            20                  25                  30          
Leu Phe Met Glu Cys Glu Glu Glu Glu Leu Glu Pro Trp Gln Lys Lys
        35                  40                  45              
Val Lys Glu Val Glu Asp Asp Asp Asp Asp Glu Pro Ile Phe Val Gly
    50                  55                  60                  
Glu Ile Ser Ser Ser Lys Pro Ala Ile Ser Asn Ile Leu Asn Arg Val
65                  70                  75                  80  
Asn Pro Ser Ser Tyr Ser Arg Gly Leu Lys Asn Gly Ala Leu Ser Arg
                85                  90                  95      
Gly Ile Thr Ala Ala Phe Lys Pro Thr Ser Gln His Tyr Thr Asn Pro
            100                 105                 110         
Thr Ser Asn Pro Val Pro Ala Ser Pro Ile Asn Phe His Pro Glu Ser
        115                 120                 125             
Arg Ser Ser Asp Ser Ser Val Ile Val Gln Pro Phe Ser Lys Pro Gly
    130                 135                 140                 
Tyr Ile Thr Asn Ser Ser Arg Val Val Ser Asn Lys Ser Ser Glu Leu
145                 150                 155                 160 
Leu Phe Asp Leu Thr Gln Asp Thr Gly Leu Ser His Tyr Gln Gly Gly
                165                 170                 175     
Pro Thr Leu Ser Met Ala Gly Met Ser Glu Ser Ser Phe Leu Ser Lys
            180                 185                 190         
Arg Pro Ser Thr Ser Glu Val Asn Asn Val Asn Pro Lys Lys Pro Lys
        195                 200                 205             
Pro Ser Glu Ser Val Ser Gly Ala Asn Ser Ser Ala Val Leu Pro Ser
    210                 215                 220                 
Val Lys Ser Pro Ser Val Thr Ser Ser Gln Ala Met Leu Ala Lys Gly
225                 230                 235                 240 
Thr Asn Thr Ser Ser Asn Gln Ser Lys Asn Gly Thr Pro Phe Pro Arg
                245                 250                 255     
Ala Cys Pro Lys Cys Asn Ile His Phe Asn Leu Leu Asp Pro Leu Lys
            260                 265                 270         
Asn His Met Lys Tyr Cys Cys Pro Asp Met Ile Asn Asn Phe Leu Gly
        275                 280                 285             
Leu Ala Lys Thr Glu Phe Ser Ser Thr Val Asn Lys Asn Thr Thr Ile
    290                 295                 300                 
Asp Ser Glu Lys Gly Lys Leu Ile Met Leu Val Asn Asp Phe Tyr Tyr
305                 310                 315                 320 
Gly Lys His Glu Gly Asp Val Gln Glu Glu Gln Lys Thr His Thr Thr
                325                 330                 335     
Phe Lys Cys Phe Ser Cys Leu Lys Ile Leu Lys Asn Asn Ile Arg Phe
            340                 345                 350         
Met Asn His Met Lys His His Leu Glu Leu Glu Lys Gln Ser Ser Glu
        355                 360                 365             
Ser Trp Glu Asn His Thr Thr Cys Gln His Cys Tyr Arg Gln Phe Pro
    370                 375                 380                 
Thr Pro Phe Gln Leu Gln Cys His Ile Glu Ser Thr His Thr Pro His
385                 390                 395                 400 
Glu Phe Ser Thr Ile Cys Lys Ile Cys Glu Leu Ser Phe Glu Thr Glu
                405                 410                 415     
His Val Leu Leu Gln His Met Lys Asp Asn His Lys Pro Gly Glu Met
            420                 425                 430         
Pro Tyr Val Cys Gln Val Cys Asn Tyr Arg Ser Ser Ser Phe Ser Asp
        435                 440                 445             
Val Glu Thr His Phe Arg Thr Ser His Glu Asn Thr Lys Asn Leu Leu
    450                 455                 460                 
Cys Pro Phe Cys Leu Lys Val Ile Lys Ile Ala Thr Pro Tyr Met His
465                 470                 475                 480 
His Tyr Met Lys His Gln Lys Lys Gly Ile His Arg Cys Thr Lys Cys
                485                 490                 495     
Arg Leu Gln Phe Leu Thr Cys Lys Glu Lys Met Asp His Lys Thr Gln
            500                 505                 510         
His His Arg Thr Phe Ile Lys Pro Lys Gln Leu Glu Gly Leu Pro Pro
        515                 520                 525             
Gly Thr Lys Val Thr Ile Arg Ala Ser Val Gly Pro Leu Gln Ser Gly
    530                 535                 540                 
Ala Ser Pro Thr Pro Ser Ile Ser Ala Ser Ala Ser Thr Leu Gln Leu
545                 550                 555                 560 
Ser Pro Pro Arg Thr Lys Asn Ile Thr Ala Lys Asn Pro Ala Lys Ser
                565                 570                 575     
Asn Thr Ser Lys Pro Asn Thr Ile Lys Ser Asn Ala Ser Lys Pro Asn
            580                 585                 590         
Thr Ser Lys Pro Asn Gly Ser Lys Ser Lys Tyr Lys Pro Lys Ile Ser
        595                 600                 605             
Asn Met Gln Lys Lys Gln Ser Thr Leu Ala Ser Ser Asn Lys Lys Ser
    610                 615                 620                 
Lys Val Asn Thr Ala Leu Arg Asn Leu Arg Tyr Arg Arg Gly Ile His
625                 630                 635                 640 
Lys Cys Ile Glu Cys Cys Ser Glu Ile Lys Asp Phe Ala Asn His Phe
                645                 650                 655     
Pro Thr Tyr Val His Cys Ser Phe Cys Arg Tyr Asn Thr Ser Cys Ser
            660                 665                 670         
Lys Ala Tyr Val Asn His Met Met Ser Phe His Ser Asn Arg Pro Ser
        675                 680                 685             
Lys Arg Phe Cys Ile Phe Lys Lys His Ser Glu Asn Leu Arg Gly Ile
    690                 695                 700                 
Thr Leu Val Cys Leu Asn Cys Asp Phe Leu Ser Asp Val Ser Gly Leu
705                 710                 715                 720 
Asp Asn Met Ala Thr His Leu Ser Gln His Lys Thr His Thr Cys Gln
                725                 730                 735     
Val Val Met Gln Lys Val Ser Val Cys Ile Pro Thr Ser Glu His Leu
            740                 745                 750         
Ser Glu Leu Lys Lys Glu Ala Pro Ala Lys Glu Gln Glu Pro Val Ser
        755                 760                 765             
Lys Glu Ile Ala Arg Pro Asn Met Ala Glu Arg Glu Thr Glu Thr Ser
    770                 775                 780                 
Asn Ser Glu Ser Lys Gln Asp Lys Ala Ala Ser Ser Lys Glu Lys Asn
785                 790                 795                 800 
Gly Cys Asn Ala Asn Ser Phe Glu Gly Ser Ser Thr Thr Lys Ser Glu
                805                 810                 815     
Glu Ser Ile Thr Val Ser Asp Lys Glu Asn Glu Thr Cys Leu Ala Asp
            820                 825                 830         
Gln Glu Thr Gly Ser Lys Asn Ile Val Ser Cys Asp Ser Asn Ile Gly
        835                 840                 845             
Ala Asp Lys Val Glu Lys Lys Lys Gln Ile Gln His Val Cys Gln Glu
    850                 855                 860                 
Met Glu Leu Lys Met Cys Gln Ser Ser Glu Asn Ile Ile Leu Ser Asp
865                 870                 875                 880 
Gln Ile Lys Asp His Asn Ser Ser Glu Ala Arg Phe Ser Ser Lys Asn
                885                 890                 895     
Ile Lys Asp Leu Arg Leu Ala Ser Asp Asn Val Ser Ile Asp Gln Phe
            900                 905                 910         
Leu Arg Lys Arg His Glu Pro Glu Ser Val Ser Ser Asp Val Ser Glu
        915                 920                 925             
Gln Gly Ser Ile His Leu Glu Pro Leu Thr Pro Ser Glu Val Leu Glu
    930                 935                 940                 
Tyr Glu Ala Thr Glu Ile Leu Gln Lys Gly Ser Gly Asp Pro Ser Ala
945                 950                 955                 960 
Lys Thr Asp Glu Val Val Ser Asp Gln Thr Asp Asp Ile Pro Gly Gly
                965                 970                 975     
Asn Asn Pro Ser Thr Thr Glu Ala Thr Val Asp Leu Glu Asp Glu Lys
            980                 985                 990         
Glu Arg Ser
        995 


<210> 1000
<211> 739
<212> PRT
<213> Homo sapiens

<400> 1000
Ser Val Met Asn Phe Thr Tyr Ile Cys Lys Ile Ile Phe Gln Ile Leu
 1               5                  10                  15      
Phe Pro Lys Met Pro Lys Arg Gln Gly Asp Phe Leu His Phe Leu Asn
            20                  25                  30          
Val Lys Lys Val Lys Thr Asp Thr Glu Asn Asn Glu Val Ser Lys Asn
        35                  40                  45              
His Cys Arg Leu Ser Lys Ala Lys Glu Pro His Phe Glu Tyr Ile Glu
    50                  55                  60                  
Gln Pro Ile Ile Glu Glu Lys Pro Ser Leu Ser Ser Lys Lys Glu Ile
65                  70                  75                  80  
Asp Asn Leu Val Leu Pro Asp Cys Trp Asn Glu Lys Gln Ala Phe Met
                85                  90                  95      
Phe Thr Glu Gln Tyr Lys Trp Leu Glu Ile Lys Glu Gly Lys Leu Gly
            100                 105                 110         
Cys Lys Asp Cys Ser Ala Val Arg His Leu Gly Ser Lys Ala Glu Lys
        115                 120                 125             
His Val His Val Ser Lys Glu Trp Ile Ala Tyr Leu Val Thr Pro Asn
    130                 135                 140                 
Gly Ser Asn Lys Thr Thr Arg Gln Ala Ser Leu Arg Lys Lys Ile Arg
145                 150                 155                 160 
Glu His Asp Val Ser Lys Ala His Gly Lys Ile Gln Asp Leu Leu Lys
                165                 170                 175     
Glu Ser Thr Asn Asp Ser Ile Cys Asn Leu Val His Lys Gln Asn Asn
            180                 185                 190         
Lys Asn Ile Asp Ala Thr Val Lys Val Phe Asn Thr Val Tyr Ser Leu
        195                 200                 205             
Val Lys His Asn Arg Pro Leu Ser Asp Ile Glu Gly Ala Arg Glu Leu
    210                 215                 220                 
Gln Glu Lys Asn Gly Glu Val Asn Cys Leu Asn Thr Arg Tyr Ser Ala
225                 230                 235                 240 
Thr Arg Ile Ala Glu His Ile Ala Lys Glu Met Lys Met Lys Ile Phe
                245                 250                 255     
Lys Asn Ile Ile Glu Glu Asn Ala Lys Ile Cys Ile Ile Ile Asp Glu
            260                 265                 270         
Ala Ser Thr Val Ser Lys Lys Thr Thr Leu Val Ile Tyr Leu Gln Cys
        275                 280                 285             
Thr Ile Gln Ser Ala Pro Ala Pro Val Met Leu Phe Val Ala Leu Lys
    290                 295                 300                 
Glu Leu Val Ser Thr Ile Ala Glu Cys Ile Val Asn Thr Leu Leu Thr
305                 310                 315                 320 
Thr Leu Asn Asp Cys Gly Phe Thr Asn Glu Tyr Leu Lys Ala Asn Leu
                325                 330                 335     
Ile Ala Phe Cys Ser Asp Gly Ala Asn Thr Ile Leu Gly Arg Lys Ser
            340                 345                 350         
Gly Val Ala Thr Lys Leu Leu Glu Asn Phe Pro Glu Ile Ile Ile Trp
        355                 360                 365             
Asn Cys Leu Asn His Arg Leu Gln Leu Ser Leu Asp Asp Ser Ile Ser
    370                 375                 380                 
Glu Ile Lys Gln Ile Asn His Leu Lys Ile Phe Ile Asp Lys Ile Tyr
385                 390                 395                 400 
Ser Ile Tyr His Gln Pro Asn Lys Asn Gln Thr Lys Leu Leu Gly Thr
                405                 410                 415     
Val Ala Lys Glu Leu Glu Thr Glu Ile Ile Lys Ile Gly Arg Val Met
            420                 425                 430         
Gly Pro Arg Trp Ala Ala Cys Ser Leu Gln Ala Ala Thr Ala Val Trp
        435                 440                 445             
His Ala Tyr Pro Ile Leu Tyr Met His Phe Ser His Ser Tyr Ser Gly
    450                 455                 460                 
Leu Ala Lys Arg Leu Ala Asn Ile Asn Phe Leu Gln Asp Leu Ala Leu
465                 470                 475                 480 
Met Ile Asp Ile Leu Glu Glu Phe Ser Val Leu Ser Thr Ala Leu Gln
                485                 490                 495     
Ser Arg Ser Thr Asn Ile Lys Lys Ala Gln Lys Leu Ile Lys Arg Thr
            500                 505                 510         
Ile Arg Ala Leu Glu Asn Leu Lys Ile Gly Thr Gly Lys Tyr Glu Ser
        515                 520                 525             
Gln Ile Glu Asp Leu Ile Lys Ser Asp Lys Phe Lys Asp Ile Pro Phe
    530                 535                 540                 
Asn Lys Asn Asn Lys Phe Asn Ala Leu Pro Arg Ser Ile Leu Leu Asp
545                 550                 555                 560 
Asn Ile Ile Gln His Met Asn Leu Arg Leu Leu Ser Asp Arg Asn His
                565                 570                 575     
Glu Asp Ile Phe Asn Tyr Phe Asp Leu Leu Glu Pro Ser Thr Trp Pro
            580                 585                 590         
Tyr Glu Glu Ile Thr Ser Pro Trp Ile Ala Gly Glu Lys Thr Leu Phe
        595                 600                 605             
His Leu Cys Lys Ile Leu Lys Tyr Glu Val Asp Leu Asn Asp Phe Arg
    610                 615                 620                 
Glu Phe Val Asn Asn Asn Ile Lys Ser Asn Asn Val Ser Ile Pro Thr
625                 630                 635                 640 
Thr Ile Tyr Lys Ala Lys Lys Ile Val Ser Thr Ile Ala Ile Asn Ser
                645                 650                 655     
Ala Glu Ala Glu Arg Gly Phe Asn Leu Met Asn Ile Ile Cys Thr Arg
            660                 665                 670         
Val Arg Asn Ser Leu Thr Ile Asp His Val Ser Asp Leu Met Thr Ile
        675                 680                 685             
Asn Leu Leu Gly Lys Glu Leu Ala Asp Trp Asp Ala Thr Pro Phe Val
    690                 695                 700                 
Lys Ser Trp Ser Asn Cys Asn His Arg Leu Ala Thr Asp Thr Arg Val
705                 710                 715                 720 
Arg Gln Lys Ser Thr Lys Val Phe His Glu Asn Gln Leu Ala Ile Trp
                725                 730                 735     
Asn Leu Lys
            


<210> 1001
<211> 991
<212> PRT
<213> Homo sapiens

<400> 1001
Arg Gln Phe Cys Ala Glu Ala Pro Thr His Leu Pro Ser Ser Leu Pro
 1               5                  10                  15      
Asp Arg Gly Pro Val Gly Val Cys Ser Tyr Thr Pro Thr Pro Val Gly
            20                  25                  30          
Arg Thr Met Ser Leu Val Ser Gln Asn Ser Arg Arg Arg Arg Arg Arg
        35                  40                  45              
Val Ala Lys Ala Thr Ala His Asn Ser Ser Trp Gly Glu Met Gln Ala
    50                  55                  60                  
Pro Asn Ala Pro Gly Leu Pro Ala Asp Val Pro Gly Ser Asp Val Pro
65                  70                  75                  80  
Gln Gly Pro Ser Asp Ser Gln Ile Leu Gln Gly Leu Cys Ala Ser Glu
                85                  90                  95      
Gly Pro Ser Thr Ser Val Leu Pro Thr Ser Ala Glu Gly Pro Ser Thr
            100                 105                 110         
Phe Val Pro Pro Thr Ile Ser Glu Ala Ser Ser Ala Ser Gly Gln Pro
        115                 120                 125             
Thr Ile Ser Glu Gly Pro Gly Thr Ser Val Leu Pro Thr Pro Ser Glu
    130                 135                 140                 
Gly Leu Ser Thr Ser Gly Pro Pro Thr Ile Ser Lys Gly Leu Cys Thr
145                 150                 155                 160 
Ser Val Thr Leu Ala Ala Ser Glu Gly Arg Asn Thr Ser Arg Pro Pro
                165                 170                 175     
Thr Ser Ser Glu Glu Pro Ser Thr Ser Val Pro Pro Thr Ala Ser Glu
            180                 185                 190         
Val Pro Ser Thr Ser Leu Pro Pro Thr Pro Gly Glu Gly Thr Ser Thr
        195                 200                 205             
Ser Val Pro Pro Thr Ala Tyr Glu Gly Pro Ser Thr Ser Val Val Pro
    210                 215                 220                 
Thr Pro Asp Glu Gly Pro Ser Thr Ser Val Leu Pro Thr Pro Gly Glu
225                 230                 235                 240 
Gly Pro Gly Thr Ser Val Pro Leu Ala Ala Thr Glu Gly Leu Ser Thr
                245                 250                 255     
Ser Val Gln Ala Thr Pro Asp Glu Gly Pro Ser Thr Ser Val Pro Pro
            260                 265                 270         
Thr Ala Thr Glu Gly Leu Ser Thr Pro Val Pro Pro Thr Arg Asp Glu
        275                 280                 285             
Gly Pro Ser Thr Ser Val Pro Ala Thr Pro Gly Glu Gly Pro Ser Thr
    290                 295                 300                 
Ser Val Leu Pro Ala Ala Ser Asp Gly Gln Ser Ile Ser Leu Val Pro
305                 310                 315                 320 
Thr Arg Gly Lys Gly Ser Ser Thr Ser Val Pro Pro Thr Ala Thr Glu
                325                 330                 335     
Gly Leu Ser Thr Ser Val Gln Pro Thr Ala Gly Glu Gly Ser Ser Thr
            340                 345                 350         
Ser Val Pro Pro Thr Pro Gly Gly Gly Leu Ser Thr Ser Val Pro Pro
        355                 360                 365             
Thr Ala Thr Glu Glu Leu Ser Thr Ser Val Pro Pro Thr Pro Gly Glu
    370                 375                 380                 
Gly Pro Ser Thr Ser Val Leu Pro Ile Pro Gly Glu Gly Leu Ser Thr
385                 390                 395                 400 
Ser Val Pro Pro Thr Ala Ser Asp Gly Ser Asp Thr Ser Val Pro Pro
                405                 410                 415     
Thr Pro Gly Glu Gly Ala Ser Thr Leu Val Gln Pro Thr Ala Pro Asp
            420                 425                 430         
Gly Pro Gly Ser Ser Val Leu Pro Asn Pro Gly Glu Gly Pro Ser Thr
        435                 440                 445             
Leu Phe Ser Ser Ser Ala Ser Val Asp Arg Asn Pro Ser Lys Cys Ser
    450                 455                 460                 
Leu Val Leu Pro Ser Pro Arg Val Thr Lys Ala Ser Val Asp Ser Asp
465                 470                 475                 480 
Ser Glu Gly Pro Lys Gly Ala Glu Gly Pro Ile Glu Phe Glu Val Leu
                485                 490                 495     
Arg Asp Cys Glu Ser Pro Asn Ser Ile Ser Ile Met Gly Leu Asn Thr
            500                 505                 510         
Ser Arg Val Ala Ile Thr Leu Lys Pro Gln Asp Pro Met Glu Gln Asn
        515                 520                 525             
Val Ala Glu Leu Leu Gln Phe Leu Leu Val Lys Asp Gln Ser Lys Tyr
    530                 535                 540                 
Pro Ile Arg Glu Ser Glu Met Arg Glu Tyr Ile Val Lys Glu Tyr Arg
545                 550                 555                 560 
Asn Gln Phe Pro Glu Ile Leu Arg Arg Ala Ala Ala His Leu Glu Cys
                565                 570                 575     
Ile Phe Arg Phe Glu Leu Arg Glu Leu Asp Pro Glu Ala His Thr Tyr
            580                 585                 590         
Ile Leu Leu Asn Lys Leu Gly Pro Val Pro Phe Glu Gly Leu Glu Glu
        595                 600                 605             
Ser Pro Asn Gly Pro Lys Met Gly Leu Leu Met Met Ile Leu Gly Gln
    610                 615                 620                 
Ile Phe Leu Asn Gly Asn Gln Ala Lys Glu Ala Glu Ile Trp Glu Met
625                 630                 635                 640 
Leu Trp Arg Met Gly Val Gln Arg Glu Arg Arg Leu Ser Ile Phe Gly
                645                 650                 655     
Asn Pro Lys Arg Leu Leu Ser Val Glu Phe Val Trp Gln Arg Tyr Leu
            660                 665                 670         
Asp Tyr Arg Pro Val Thr Asp Cys Lys Pro Val Glu Tyr Glu Phe Phe
        675                 680                 685             
Trp Gly Pro Arg Ser His Leu Glu Thr Thr Lys Met Lys Ile Leu Lys
    690                 695                 700                 
Phe Met Ala Lys Ile Tyr Asn Lys Asp Pro Met Asp Trp Pro Glu Lys
705                 710                 715                 720 
Tyr Asn Glu Ala Leu Glu Glu Asp Ala Ala Arg Ala Phe Ala Glu Gly
                725                 730                 735     
Trp Gln Ala Leu Pro His Phe Arg Arg Pro Phe Phe Glu Glu Ala Ala
            740                 745                 750         
Ala Glu Val Pro Ser Pro Asp Ser Glu Val Ser Ser Tyr Ser Ser Lys
        755                 760                 765             
Tyr Ala Pro His Ser Trp Pro Glu Ser Arg Leu Glu Ser Lys Ala Arg
    770                 775                 780                 
Lys Leu Val Gln Leu Phe Leu Leu Met Asp Ser Thr Lys Leu Pro Ile
785                 790                 795                 800 
Pro Lys Lys Gly Ile Leu Tyr Tyr Ile Gly Arg Glu Cys Ser Lys Val
                805                 810                 815     
Phe Pro Asp Leu Leu Asn Arg Ala Ala Arg Thr Leu Asn His Val Tyr
            820                 825                 830         
Gly Thr Glu Leu Val Val Leu Asp Pro Arg Asn His Ser Tyr Thr Leu
        835                 840                 845             
Tyr Asn Arg Arg Glu Met Glu Glu Thr Glu Glu Ile Val Asp Ser Pro
    850                 855                 860                 
Asn Arg Pro Gly Asn Asn Phe Leu Met Gln Val Leu Ser Phe Ile Phe
865                 870                 875                 880 
Ile Met Gly Asn His Ala Arg Glu Ser Ala Val Trp Ala Phe Leu Arg
                885                 890                 895     
Gly Leu Gly Val Gln Ala Gly Arg Lys His Val Ile Thr Cys Arg Tyr
            900                 905                 910         
Leu Ser Gln Arg Tyr Ile Asp Ser Leu Arg Val Pro Asp Ser Asp Pro
        915                 920                 925             
Val Gln Tyr Glu Phe Val Trp Gly Pro Arg Ala Arg Leu Glu Thr Ser
    930                 935                 940                 
Lys Met Lys Ala Leu Arg Tyr Val Ala Arg Ile His Arg Lys Glu Pro
945                 950                 955                 960 
Gln Asp Trp Pro Gln Gln Tyr Arg Glu Ala Met Glu Asp Glu Ala Asn
                965                 970                 975     
Arg Ala Asp Val Gly His Arg Gln Ile Phe Val His Asn Phe Arg
            980                 985                 990     


<210> 1002
<211> 690
<212> PRT
<213> Homo sapiens

<400> 1002
Val Ser Thr Ile Lys Leu Phe Leu Pro Asp Gly Met Glu Ala Arg Leu
 1               5                  10                  15      
Arg Ser Asp Val Ile His Ala Pro Leu Pro Ser Pro Val Asp Lys Val
            20                  25                  30          
Ala Ala Asn Thr Pro Ser Met Tyr Ser Gln Glu Leu Phe Gln Leu Ser
        35                  40                  45              
Gln Tyr Leu Gln Glu Ala Leu His Arg Glu Gln Met Leu Glu Gln Lys
    50                  55                  60                  
Leu Ala Thr Leu Gln Arg Leu Leu Ala Ile Thr Gln Glu Ala Ser Asp
65                  70                  75                  80  
Thr Ser Trp Gln Ala Leu Ile Asp Glu Asp Arg Leu Leu Ser Arg Leu
                85                  90                  95      
Glu Val Met Gly Asn Gln Leu Gln Ala Cys Ser Lys Asn Gln Thr Glu
            100                 105                 110         
Asp Ser Leu Arg Lys Glu Leu Ile Ala Leu Gln Glu Asp Lys His Asn
        115                 120                 125             
Tyr Glu Thr Thr Ala Lys Glu Ser Leu Arg Arg Val Leu Gln Glu Lys
    130                 135                 140                 
Ile Glu Val Val Arg Lys Leu Ser Glu Val Glu Arg Ser Leu Ser Asn
145                 150                 155                 160 
Thr Glu Asp Glu Cys Thr His Leu Lys Glu Met Asn Glu Arg Thr Gln
                165                 170                 175     
Glu Glu Leu Arg Glu Leu Ala Asn Lys Tyr Asn Gly Ala Val Asn Glu
            180                 185                 190         
Ile Lys Asp Leu Ser Asp Lys Leu Lys Val Ala Glu Gly Lys Gln Glu
        195                 200                 205             
Glu Ile Gln Gln Lys Gly Gln Ala Glu Lys Lys Glu Leu Gln His Lys
    210                 215                 220                 
Ile Asp Glu Met Glu Glu Lys Glu Gln Glu Leu Gln Ala Lys Ile Glu
225                 230                 235                 240 
Ala Leu Gln Ala Asp Asn Asp Phe Thr Asn Glu Arg Leu Thr Ala Leu
                245                 250                 255     
Gln Glu His Leu Leu Ser Lys Ser Gly Gly Asp Cys Thr Phe Ile His
            260                 265                 270         
Gln Phe Ile Glu Cys Gln Lys Lys Leu Ile Val Glu Gly His Leu Thr
        275                 280                 285             
Lys Ala Val Glu Glu Thr Lys Leu Ser Lys Glu Asn Gln Thr Arg Ala
    290                 295                 300                 
Lys Glu Ser Asp Phe Ser Asp Thr Leu Ser Pro Ser Lys Glu Lys Ser
305                 310                 315                 320 
Ser Asp Asp Thr Thr Asp Ala Gln Met Asp Glu Gln Asp Leu Asn Glu
                325                 330                 335     
Pro Leu Ala Lys Val Ser Leu Leu Lys Asp Asp Leu Gln Gly Ala Gln
            340                 345                 350         
Ser Glu Ile Glu Ala Lys Gln Glu Ile Gln His Leu Arg Lys Glu Leu
        355                 360                 365             
Ile Glu Ala Gln Glu Leu Ala Arg Thr Ser Lys Gln Lys Cys Phe Glu
    370                 375                 380                 
Leu Gln Ala Leu Leu Glu Glu Glu Arg Lys Ala Tyr Arg Asn Gln Val
385                 390                 395                 400 
Glu Glu Ser Thr Lys Gln Ile Gln Val Leu Gln Ala Gln Leu Gln Arg
                405                 410                 415     
Leu His Ile Asp Thr Glu Asn Leu Arg Glu Glu Lys Asp Ser Glu Ile
            420                 425                 430         
Thr Ser Thr Arg Asp Glu Leu Leu Ser Ala Arg Asp Glu Ile Leu Leu
        435                 440                 445             
Leu His Gln Ala Ala Ala Lys Val Ala Ser Glu Arg Asp Thr Asp Ile
    450                 455                 460                 
Ala Ser Leu Gln Glu Glu Leu Lys Lys Val Arg Ala Glu Leu Glu Arg
465                 470                 475                 480 
Trp Arg Lys Ala Ala Ser Glu Tyr Glu Lys Glu Ile Thr Ser Leu Gln
                485                 490                 495     
Asn Ser Phe Gln Leu Arg Cys Gln Gln Cys Glu Asp Gln Gln Arg Glu
            500                 505                 510         
Glu Ala Thr Arg Leu Gln Gly Glu Leu Glu Lys Leu Arg Lys Glu Trp
        515                 520                 525             
Asn Ala Leu Glu Thr Glu Cys His Ser Leu Lys Arg Glu Asn Val Leu
    530                 535                 540                 
Leu Ser Ser Glu Leu Gln Arg Gln Glu Lys Glu Leu His Asn Ser Gln
545                 550                 555                 560 
Lys Gln Ser Leu Glu Leu Thr Ser Asp Leu Ser Ile Leu Gln Met Ser
                565                 570                 575     
Arg Lys Glu Leu Glu Asn Gln Val Gly Ser Leu Lys Glu Gln His Leu
            580                 585                 590         
Arg Asp Ser Ala Asp Leu Lys Thr Leu Leu Ser Lys Ala Glu Asn Gln
        595                 600                 605             
Ala Lys Asp Val Gln Lys Glu Tyr Glu Lys Thr Gln Thr Val Leu Ser
    610                 615                 620                 
Glu Leu Lys Leu Lys Phe Glu Met Thr Glu Gln Glu Lys Gln Ser Ile
625                 630                 635                 640 
Thr Asp Glu Leu Lys Gln Cys Lys Asn Asn Leu Lys Leu Leu Arg Glu
                645                 650                 655     
Lys Gly Asn Asn Lys Pro Trp Pro Trp Met Pro Met Leu Ala Ala Leu
            660                 665                 670         
Val Ala Val Thr Ala Ile Val Leu Tyr Val Pro Gly Leu Ala Arg Ala
        675                 680                 685             
Ser Pro
    690 


<210> 1003
<211> 690
<212> PRT
<213> Homo sapiens

<400> 1003
Val Ser Thr Ile Lys Leu Phe Leu Pro Asp Gly Met Glu Ala Arg Leu
 1               5                  10                  15      
Arg Ser Asp Val Ile His Ala Pro Leu Pro Ser Pro Val Asp Lys Val
            20                  25                  30          
Ala Ala Asn Thr Pro Ser Met Tyr Ser Gln Glu Leu Phe Gln Leu Ser
        35                  40                  45              
Gln Tyr Leu Gln Glu Ala Leu His Arg Glu Gln Met Leu Glu Gln Lys
    50                  55                  60                  
Leu Ala Thr Leu Gln Arg Leu Leu Ala Ile Thr Gln Glu Ala Ser Asp
65                  70                  75                  80  
Thr Ser Trp Gln Ala Leu Ile Asp Glu Asp Arg Leu Leu Ser Arg Leu
                85                  90                  95      
Glu Val Met Gly Asn Gln Leu Gln Ala Cys Ser Lys Asn Gln Thr Glu
            100                 105                 110         
Asp Ser Leu Arg Lys Glu Leu Ile Ala Leu Gln Glu Asp Lys His Asn
        115                 120                 125             
Tyr Glu Thr Thr Ala Lys Glu Ser Leu Arg Arg Val Leu Gln Glu Lys
    130                 135                 140                 
Ile Glu Val Val Arg Lys Leu Ser Glu Val Glu Arg Ser Leu Ser Asn
145                 150                 155                 160 
Thr Glu Asp Glu Cys Thr His Leu Lys Glu Met Asn Glu Arg Thr Gln
                165                 170                 175     
Glu Glu Leu Arg Glu Leu Ala Asn Lys Tyr Asn Gly Ala Val Asn Glu
            180                 185                 190         
Ile Lys Asp Leu Ser Asp Lys Leu Lys Val Ala Glu Gly Lys Gln Glu
        195                 200                 205             
Glu Ile Gln Gln Lys Gly Gln Ala Glu Lys Lys Glu Leu Gln His Lys
    210                 215                 220                 
Ile Asp Glu Met Glu Glu Lys Glu Gln Glu Leu Gln Ala Lys Ile Glu
225                 230                 235                 240 
Ala Leu Gln Ala Asp Asn Asp Phe Thr Asn Glu Arg Leu Thr Ala Leu
                245                 250                 255     
Gln Glu His Leu Leu Ser Lys Ser Gly Gly Asp Cys Thr Phe Ile His
            260                 265                 270         
Gln Phe Ile Glu Cys Gln Lys Lys Leu Ile Val Glu Gly His Leu Thr
        275                 280                 285             
Lys Ala Val Glu Glu Thr Lys Leu Ser Lys Glu Asn Gln Thr Arg Ala
    290                 295                 300                 
Lys Glu Ser Asp Phe Ser Asp Thr Leu Ser Pro Ser Lys Glu Lys Ser
305                 310                 315                 320 
Ser Asp Asp Thr Thr Asp Ala Gln Met Asp Glu Gln Asp Leu Asn Glu
                325                 330                 335     
Pro Leu Ala Lys Val Ser Leu Leu Lys Asp Asp Leu Gln Gly Ala Gln
            340                 345                 350         
Ser Glu Ile Glu Ala Lys Gln Glu Ile Gln His Leu Arg Lys Glu Leu
        355                 360                 365             
Ile Glu Ala Gln Glu Leu Ala Arg Thr Ser Lys Gln Lys Cys Phe Glu
    370                 375                 380                 
Leu Gln Ala Leu Leu Glu Glu Glu Arg Lys Ala Tyr Arg Asn Gln Val
385                 390                 395                 400 
Glu Glu Ser Thr Lys Gln Ile Gln Val Leu Gln Ala Gln Leu Gln Arg
                405                 410                 415     
Leu His Ile Asp Thr Glu Asn Leu Arg Glu Glu Lys Asp Ser Glu Ile
            420                 425                 430         
Thr Ser Thr Arg Asp Glu Leu Leu Ser Ala Arg Asp Glu Ile Leu Leu
        435                 440                 445             
Leu His Gln Ala Ala Ala Lys Val Ala Ser Glu Arg Asp Thr Asp Ile
    450                 455                 460                 
Ala Ser Leu Gln Glu Glu Leu Lys Lys Val Arg Ala Glu Leu Glu Arg
465                 470                 475                 480 
Trp Arg Lys Ala Ala Ser Glu Tyr Glu Lys Glu Ile Thr Ser Leu Gln
                485                 490                 495     
Asn Ser Phe Gln Leu Arg Cys Gln Gln Cys Glu Asp Gln Gln Arg Glu
            500                 505                 510         
Glu Ala Thr Arg Leu Gln Gly Glu Leu Glu Lys Leu Arg Lys Glu Trp
        515                 520                 525             
Asn Ala Leu Glu Thr Glu Cys His Ser Leu Lys Arg Glu Asn Val Leu
    530                 535                 540                 
Leu Ser Ser Glu Leu Gln Arg Gln Glu Lys Glu Leu His Asn Ser Gln
545                 550                 555                 560 
Lys Gln Ser Leu Glu Leu Thr Ser Asp Leu Ser Ile Leu Gln Met Ser
                565                 570                 575     
Arg Lys Glu Leu Glu Asn Gln Val Gly Ser Leu Lys Glu Gln His Leu
            580                 585                 590         
Arg Asp Ser Ala Asp Leu Lys Thr Leu Leu Ser Lys Ala Glu Asn Gln
        595                 600                 605             
Ala Lys Asp Val Gln Lys Glu Tyr Glu Lys Thr Gln Thr Val Leu Ser
    610                 615                 620                 
Glu Leu Lys Leu Lys Phe Glu Met Thr Glu Gln Glu Lys Gln Ser Ile
625                 630                 635                 640 
Thr Asp Glu Leu Lys Gln Cys Lys Asn Asn Leu Lys Leu Leu Arg Glu
                645                 650                 655     
Lys Gly Asn Asn Lys Pro Trp Pro Trp Met Pro Met Leu Ala Ala Leu
            660                 665                 670         
Val Ala Val Thr Ala Ile Val Leu Tyr Val Pro Gly Leu Ala Arg Ala
        675                 680                 685             
Ser Pro
    690 


<210> 1004
<211> 1003
<212> PRT
<213> Homo sapiens

<400> 1004
Ser Ser Gly Pro Asn Cys Ala Pro Gly Ser Ser Ser Ser Ser Ser Ser
 1               5                  10                  15      
Asp Glu Ala Gly Asp Pro Asn Glu Ala Pro Ser Pro Asp Thr Leu Leu
            20                  25                  30          
Gly Ala Leu Ala Arg Arg Gln Leu Asn Leu Gly Gln Leu Leu Glu Asp
        35                  40                  45              
Thr Glu Ser Tyr Leu Gln Ala Phe Leu Ala Gly Ala Ala Gly Pro Leu
    50                  55                  60                  
Asn Gly Asp His Pro Gly Pro Gly Gln Ser Ser Ser Pro Asp Gln Ala
65                  70                  75                  80  
Pro Pro Gln Leu Ser Lys Ser Lys Gly Leu Pro Lys Ser Ala Trp Gly
                85                  90                  95      
Gly Gly Thr Pro Glu Ala His Arg Pro Gly Phe Gly Ala Thr Ser Glu
            100                 105                 110         
Gly Gln Gly Pro Leu Pro Phe Leu Ser Met Phe Met Gly Ala Gly Asp
        115                 120                 125             
Ala Pro Leu Gly Ser Arg Pro Gly His Pro His Ser Ser Ser Gln Val
    130                 135                 140                 
Lys Ser Lys Leu Gln Ile Gly Pro Pro Ser Pro Gly Glu Ala Gln Gly
145                 150                 155                 160 
Pro Leu Leu Pro Ser Pro Ala Arg Gly Leu Lys Phe Leu Lys Leu Pro
                165                 170                 175     
Pro Thr Ser Glu Lys Ser Pro Ser Pro Gly Gly Pro Gln Leu Ser Pro
            180                 185                 190         
Gln Leu Pro Arg Asn Ser Arg Ile Pro Cys Arg Asn Ser Gly Ser Asp
        195                 200                 205             
Gly Ser Pro Ser Pro Leu Leu Ala Arg Arg Gly Leu Gly Gly Gly Glu
    210                 215                 220                 
Leu Ser Pro Glu Gly Ala Gln Gly Leu Pro Thr Ser Pro Ser Pro Cys
225                 230                 235                 240 
Tyr Thr Thr Pro Asp Ser Thr Gln Leu Arg Pro Pro Gln Ser Ala Leu
                245                 250                 255     
Ser Thr Thr Leu Ser Pro Gly Pro Val Val Ser Pro Cys Tyr Glu Asn
            260                 265                 270         
Ile Leu Asp Leu Ser Arg Ser Thr Phe Arg Gly Pro Ser Pro Glu Pro
        275                 280                 285             
Pro Pro Ser Pro Leu Gln Val Pro Thr Tyr Pro Gln Leu Thr Leu Glu
    290                 295                 300                 
Val Pro Gln Ala Pro Glu Val Leu Arg Ser Pro Gly Val Pro Pro Ser
305                 310                 315                 320 
Pro Cys Leu Pro Glu Ser Tyr Pro Tyr Gly Ser Pro Gln Glu Lys Ser
                325                 330                 335     
Leu Asp Lys Ala Gly Ser Glu Ser Pro His Pro Gly Arg Arg Thr Pro
            340                 345                 350         
Gly Asn Ser Ser Lys Lys Pro Ser Gln Gly Ser Gly Arg Arg Pro Gly
        355                 360                 365             
Asp Pro Gly Ser Thr Pro Leu Arg Asp Arg Leu Ala Ala Leu Gly Lys
    370                 375                 380                 
Leu Lys Thr Gly Pro Glu Gly Ala Leu Gly Ser Glu Lys Asn Gly Val
385                 390                 395                 400 
Pro Ala Arg Pro Gly Thr Glu Lys Thr Arg Gly Pro Gly Lys Ser Gly
                405                 410                 415     
Glu Ser Ala Gly Asp Met Val Pro Ser Ile His Arg Pro Leu Glu Gln
            420                 425                 430         
Leu Glu Ala Lys Gly Gly Ile Arg Gly Ala Val Ala Leu Gly Thr Asn
        435                 440                 445             
Ser Leu Lys Gln Gln Glu Pro Gly Leu Met Gly Asp Pro Gly Ala Arg
    450                 455                 460                 
Val Tyr Ser Ser His Ser Met Gly Ala Arg Val Asp Leu Glu Pro Val
465                 470                 475                 480 
Ser Pro Arg Ser Cys Leu Thr Lys Val Glu Leu Ala Lys Ser Arg Leu
                485                 490                 495     
Ala Gly Ala Leu Cys Pro Gln Val Pro Arg Thr Pro Ala Lys Val Pro
            500                 505                 510         
Thr Ser Ala Pro Ser Leu Gly Lys Pro Asn Lys Ser Pro His Ser Ser
        515                 520                 525             
Pro Thr Lys Leu Pro Ser Lys Ser Pro Thr Lys Val Val Pro Arg Pro
    530                 535                 540                 
Gly Ala Pro Leu Val Thr Lys Glu Ser Pro Lys Pro Asp Lys Gly Lys
545                 550                 555                 560 
Gly Pro Pro Trp Ala Asp Cys Gly Ser Thr Thr Ala Gln Ser Thr Pro
                565                 570                 575     
Leu Val Pro Gly Pro Thr Asp Pro Ser Gln Gly Pro Glu Gly Leu Ala
            580                 585                 590         
Pro His Ser Ala Ile Glu Glu Lys Val Met Lys Gly Ile Glu Glu Asn
        595                 600                 605             
Val Leu Arg Leu Gln Gly Gln Glu Arg Ala Pro Gly Ala Glu Val Lys
    610                 615                 620                 
His Arg Asn Thr Ser Ser Ile Ala Ser Trp Phe Gly Leu Lys Lys Ser
625                 630                 635                 640 
Lys Leu Pro Ala Leu Asn Arg Arg Thr Glu Ala Thr Lys Asn Lys Glu
                645                 650                 655     
Gly Ala Gly Gly Gly Ser Pro Leu Arg Arg Glu Val Lys Met Glu Ala
            660                 665                 670         
Arg Lys Leu Glu Ala Glu Ser Leu Asn Ile Ser Lys Leu Met Ala Lys
        675                 680                 685             
Ala Glu Asp Leu Arg Arg Ala Leu Glu Glu Glu Lys Ala Tyr Leu Ser
    690                 695                 700                 
Ser Arg Ala Arg Pro Arg Pro Gly Gly Pro Ala Pro Gly Pro Asn Thr
705                 710                 715                 720 
Gly Leu Gly Gln Val Gln Gly Gln Leu Ala Gly Met Tyr Gln Gly Ala
                725                 730                 735     
Asp Thr Phe Met Gln Gln Leu Leu Asn Arg Val Asp Gly Lys Glu Leu
            740                 745                 750         
Pro Ser Lys Ser Trp Arg Glu Pro Lys Pro Glu Tyr Gly Asp Phe Gln
        755                 760                 765             
Pro Val Ser Ser Asp Pro Lys Ser Pro Trp Pro Ala Cys Gly Pro Arg
    770                 775                 780                 
Asn Gly Leu Val Gly Pro Leu Gln Gly Cys Gly Lys Pro Pro Gly Lys
785                 790                 795                 800 
Pro Ser Ser Glu Pro Gly Arg Arg Glu Glu Thr Pro Ser Glu Asp Ser
                805                 810                 815     
Leu Ala Glu Pro Val Pro Thr Ser His Phe Thr Ala Cys Gly Ser Leu
            820                 825                 830         
Thr Arg Thr Leu Asp Ser Gly Ile Gly Thr Phe Pro Pro Pro Asp His
        835                 840                 845             
Gly Ser Ser Gly Thr Pro Ser Lys Asn Leu Pro Lys Thr Lys Pro Pro
    850                 855                 860                 
Arg Leu Asp Pro Pro Pro Gly Val Pro Pro Ala Arg Pro Pro Pro Leu
865                 870                 875                 880 
Thr Lys Val Pro Arg Arg Ala His Thr Leu Glu Arg Glu Val Pro Gly
                885                 890                 895     
Ile Glu Glu Leu Leu Val Ser Gly Arg His Pro Ser Met Pro Ala Phe
            900                 905                 910         
Pro Ala Leu Leu Pro Ala Ala Pro Gly His Arg Gly His Glu Thr Cys
        915                 920                 925             
Pro Asp Asp Pro Cys Glu Asp Pro Gly Pro Thr Pro Pro Val Gln Leu
    930                 935                 940                 
Ala Lys Asn Trp Thr Phe Pro Asn Thr Arg Ala Ala Gly Ser Ser Ser
945                 950                 955                 960 
Asp Pro Leu Met Cys Pro Pro Arg Gln Leu Glu Gly Leu Pro Arg Thr
                965                 970                 975     
Pro Met Val Arg Ile Ala Ala Glu Glu Arg Glu Arg Thr Arg Glu Gln
            980                 985                 990         
Glu Gly Val Met Trp Gly Asp Gln Phe Leu Gln
        995                 1000            


<210> 1005
<211> 1122
<212> PRT
<213> Homo sapiens

<400> 1005
Trp Thr Glu Gln Ser Gln Glu Phe Ala Ala Gln Thr Lys Arg Leu Val
 1               5                  10                  15      
Gly Asp Val Leu Leu Ala Thr Ala Phe Leu Ser Tyr Ser Gly Pro Phe
            20                  25                  30          
Asn Gln Glu Phe Arg Asp Leu Leu Leu Asn Asp Trp Arg Lys Glu Met
        35                  40                  45              
Lys Ala Arg Lys Ile Pro Phe Gly Lys Asn Leu Asn Leu Ser Glu Met
    50                  55                  60                  
Leu Ile Asp Ala Pro Thr Ile Ser Glu Trp Asn Leu Gln Gly Leu Pro
65                  70                  75                  80  
Asn Asp Asp Leu Ser Ile Gln Asn Gly Ile Ile Val Thr Lys Ala Ser
                85                  90                  95      
Arg Tyr Pro Leu Leu Ile Asp Pro Gln Thr Gln Gly Lys Ile Trp Ile
            100                 105                 110         
Lys Asn Lys Glu Ser Arg Asn Glu Leu Gln Ile Thr Ser Leu Asn His
        115                 120                 125             
Lys Tyr Phe Arg Asn His Leu Glu Asp Ser Leu Ser Leu Gly Arg Pro
    130                 135                 140                 
Leu Leu Ile Glu Asp Val Gly Glu Glu Leu Asp Pro Ala Leu Asp Asn
145                 150                 155                 160 
Val Leu Glu Arg Asn Phe Ile Lys Thr Gly Ser Thr Phe Lys Val Lys
                165                 170                 175     
Val Gly Asp Lys Glu Val Asp Val Leu Asp Gly Phe Arg Leu Tyr Ile
            180                 185                 190         
Thr Thr Lys Leu Pro Asn Pro Ala Tyr Thr Pro Glu Ile Ser Ala Arg
        195                 200                 205             
Thr Ser Ile Ile Asp Phe Thr Val Thr Met Lys Gly Leu Glu Asp Gln
    210                 215                 220                 
Leu Leu Gly Arg Val Ile Leu Thr Glu Lys Gln Glu Leu Glu Lys Glu
225                 230                 235                 240 
Arg Thr His Leu Met Glu Asp Val Thr Ala Asn Lys Arg Arg Met Lys
                245                 250                 255     
Glu Leu Glu Asp Asn Leu Leu Tyr Arg Leu Thr Ser Thr Gln Gly Ser
            260                 265                 270         
Leu Val Glu Asp Glu Ser Leu Ile Val Val Leu Ser Asn Thr Lys Arg
        275                 280                 285             
Thr Ala Glu Glu Val Thr Gln Lys Leu Glu Ile Ser Ala Glu Thr Glu
    290                 295                 300                 
Val Gln Ile Asn Ser Ala Arg Glu Glu Tyr Arg Pro Val Ala Thr Arg
305                 310                 315                 320 
Gly Ser Ile Leu Tyr Phe Leu Ile Thr Glu Met Arg Leu Val Asn Glu
                325                 330                 335     
Met Tyr Gln Thr Ser Leu Arg Gln Phe Leu Gly Leu Phe Asp Leu Ser
            340                 345                 350         
Leu Ala Arg Ser Val Lys Ser Pro Ile Thr Ser Lys Arg Ile Ala Asn
        355                 360                 365             
Ile Ile Glu His Met Thr Tyr Glu Val Tyr Lys Tyr Ala Ala Arg Gly
    370                 375                 380                 
Leu Tyr Glu Glu His Lys Phe Leu Phe Thr Leu Leu Leu Thr Leu Lys
385                 390                 395                 400 
Ile Asp Ile Gln Arg Asn Arg Val Lys His Glu Glu Phe Leu Thr Leu
                405                 410                 415     
Ile Lys Gly Gly Ala Ser Leu Asp Leu Lys Ala Cys Pro Pro Lys Pro
            420                 425                 430         
Ser Lys Trp Ile Leu Asp Ile Thr Trp Leu Asn Leu Val Glu Leu Ser
        435                 440                 445             
Lys Leu Arg Gln Phe Ser Asp Val Leu Asp Gln Ile Ser Arg Asn Glu
    450                 455                 460                 
Lys Met Trp Lys Ile Trp Phe Asp Lys Glu Asn Pro Glu Glu Glu Pro
465                 470                 475                 480 
Leu Pro Asn Ala Tyr Asp Lys Ser Leu Asp Cys Phe Arg Arg Leu Leu
                485                 490                 495     
Leu Ile Arg Ser Trp Cys Pro Asp Arg Thr Ile Ala Gln Ala Arg Lys
            500                 505                 510         
Tyr Ile Val Asp Ser Met Gly Glu Lys Tyr Ala Glu Gly Val Ile Leu
        515                 520                 525             
Asp Leu Glu Lys Thr Trp Glu Glu Ser Asp Pro Arg Thr Pro Leu Ile
    530                 535                 540                 
Cys Leu Leu Ser Met Gly Ser Asp Pro Thr Asp Ser Ile Ile Ala Leu
545                 550                 555                 560 
Gly Lys Arg Leu Lys Ile Glu Thr Arg Tyr Val Ser Met Gly Gln Gly
                565                 570                 575     
Gln Glu Val His Ala Arg Lys Leu Leu Gln Gln Thr Met Ala Asn Gly
            580                 585                 590         
Gly Trp Ala Leu Leu Gln Asn Cys His Leu Gly Leu Asp Phe Met Asp
        595                 600                 605             
Glu Leu Met Asp Ile Ile Ile Glu Thr Glu Leu Val His Asp Ala Phe
    610                 615                 620                 
Arg Leu Trp Met Thr Thr Glu Val His Lys Gln Phe Pro Ile Thr Leu
625                 630                 635                 640 
Leu Gln Met Ser Ile Lys Phe Ala Asn Asp Pro Pro Gln Gly Leu Arg
                645                 650                 655     
Ala Gly Leu Lys Arg Thr Tyr Ser Gly Val Ser Gln Asp Leu Leu Asp
            660                 665                 670         
Val Ser Ser Gly Ser Gln Trp Lys Pro Met Leu Tyr Ala Val Ala Phe
        675                 680                 685             
Leu His Ser Thr Val Gln Glu Arg Arg Lys Phe Gly Ala Leu Gly Trp
    690                 695                 700                 
Asn Ile Pro Tyr Glu Phe Asn Gln Ala Asp Phe Asn Ala Thr Val Gln
705                 710                 715                 720 
Phe Ile Gln Asn His Leu Asp Asp Met Asp Val Lys Lys Gly Val Ser
                725                 730                 735     
Trp Thr Thr Ile Arg Tyr Met Ile Gly Glu Ile Gln Tyr Gly Gly Arg
            740                 745                 750         
Val Thr Asp Asp Tyr Asp Lys Arg Leu Leu Asn Thr Phe Ala Lys Val
        755                 760                 765             
Trp Phe Ser Glu Asn Met Phe Gly Pro Asp Phe Ser Phe Tyr Gln Gly
    770                 775                 780                 
Tyr Asn Ile Pro Lys Cys Ser Thr Val Asp Asn Tyr Leu Gln Tyr Ile
785                 790                 795                 800 
Gln Ser Leu Pro Ala Tyr Asp Ser Pro Glu Val Phe Gly Leu His Pro
                805                 810                 815     
Asn Ala Asp Ile Thr Tyr Gln Ser Lys Leu Ala Lys Asp Val Leu Asp
            820                 825                 830         
Thr Ile Leu Gly Ile Gln Pro Lys Asp Thr Ser Gly Gly Gly Asp Glu
        835                 840                 845             
Thr Arg Glu Ala Val Val Ala Arg Leu Ala Asp Asp Met Leu Glu Lys
    850                 855                 860                 
Leu Pro Pro Asp Tyr Val Pro Phe Glu Val Lys Glu Arg Leu Gln Lys
865                 870                 875                 880 
Met Gly Pro Phe Gln Pro Met Asn Ile Phe Leu Arg Gln Glu Ile Asp
                885                 890                 895     
Arg Met Gln Arg Val Leu Ser Leu Val Arg Ser Thr Leu Thr Glu Leu
            900                 905                 910         
Lys Leu Ala Ile Asp Gly Thr Ile Ile Met Ser Glu Asn Leu Arg Asp
        915                 920                 925             
Ala Leu Asp Cys Met Phe Asp Ala Arg Ile Pro Ala Trp Trp Lys Lys
    930                 935                 940                 
Ala Ser Trp Val Ser Ser Thr Leu Gly Phe Trp Phe Thr Glu Leu Ile
945                 950                 955                 960 
Glu Arg Asn Ser Gln Phe Thr Ser Trp Val Phe Asn Gly Arg Pro His
                965                 970                 975     
Cys Phe Trp Met Thr Gly Phe Phe Asn Pro Gln Gly Phe Leu Thr Ala
            980                 985                 990         
Met Arg Gln Glu Ile Thr Arg Ala Asn Lys Gly Trp Ala Leu Asp Asn
        995                 1000                1005            
Met Val Leu Cys Asn Glu Val Thr Lys Trp Met Lys Asp Asp Ile Ser
    1010                1015                1020                
Ala Pro Pro Thr Glu Gly Val Tyr Val Tyr Gly Leu Tyr Leu Glu Gly
1025                1030                1035                1040
Ala Gly Trp Asp Lys Arg Asn Met Lys Leu Ile Glu Ser Lys Pro Lys
                1045                1050                1055    
Val Leu Phe Glu Leu Met Pro Val Ile Arg Ile Tyr Ala Glu Asn Asn
            1060                1065                1070        
Thr Leu Arg Asp Pro Arg Phe Tyr Ser Cys Pro Ile Tyr Lys Lys Pro
        1075                1080                1085            
Val Arg Thr Asp Leu Asn Tyr Ile Ala Ala Val Asp Leu Arg Thr Ala
    1090                1095                1100                
Gln Thr Pro Glu His Trp Val Leu Arg Gly Val Ala Leu Leu Cys Asp
1105                1110                1115                1120
Val Lys
        


<210> 1006
<211> 937
<212> PRT
<213> Homo sapiens

<400> 1006
Thr Val Lys Glu Phe Arg Ala Leu Gly Thr Cys Tyr Leu Asp Gln Phe
 1               5                  10                  15      
Glu Ala Ser Leu Ile Tyr Trp Thr Asn Trp Gln Gln Lys Met Lys Ser
            20                  25                  30          
Ser Val Ala Gln Ile Lys Pro Ser Ser Gly His Asp Arg Arg Glu Asn
        35                  40                  45              
Leu Asn Ser Tyr Gln Arg Asn Ser Ser Pro Glu Asp Arg Tyr Glu Glu
    50                  55                  60                  
Gln Glu Arg Ser Pro Arg Asp Arg Asp Tyr Phe Asp Tyr Ser Arg Ser
65                  70                  75                  80  
Asp Tyr Glu His Ser Arg Arg Gly Arg Ser Tyr Asp Ser Ser Met Glu
                85                  90                  95      
Ser Arg Asn Arg Asp Arg Glu Lys Arg Arg Glu Arg Glu Arg Asp Thr
            100                 105                 110         
Asp Arg Lys Arg Ser Arg Lys Ser Pro Ser Pro Gly Arg Arg Asn Pro
        115                 120                 125             
Glu Thr Ser Val Thr Gln Ser Ser Ser Ala Gln Asp Glu Pro Ala Thr
    130                 135                 140                 
Lys Lys Lys Lys Asp Glu Leu Asp Pro Leu Leu Thr Arg Thr Gly Gly
145                 150                 155                 160 
Ala Tyr Ile Pro Pro Ala Lys Leu Arg Met Met Gln Glu Gln Ile Thr
                165                 170                 175     
Asp Lys Asn Ser Leu Ala Tyr Gln Arg Met Ser Trp Glu Ala Leu Lys
            180                 185                 190         
Lys Ser Ile Asn Gly Leu Ile Asn Lys Val Asn Ile Ser Asn Ile Ser
        195                 200                 205             
Ile Ile Ile Gln Glu Leu Leu Gln Glu Asn Ile Val Arg Gly Arg Gly
    210                 215                 220                 
Leu Leu Ser Arg Ser Val Leu Gln Ala Gln Ser Ala Ser Pro Ile Phe
225                 230                 235                 240 
Thr His Val Tyr Ala Ala Leu Val Ala Ile Ile Asn Ser Lys Phe Pro
                245                 250                 255     
Gln Ile Gly Glu Leu Ile Leu Lys Arg Leu Ile Leu Asn Phe Arg Lys
            260                 265                 270         
Gly Tyr Arg Arg Asn Asp Lys Gln Leu Cys Leu Thr Ala Ser Lys Phe
        275                 280                 285             
Val Ala His Leu Ile Asn Gln Asn Val Ala His Glu Val Leu Cys Leu
    290                 295                 300                 
Glu Met Leu Thr Leu Leu Leu Glu Arg Pro Thr Asp Asp Ser Val Glu
305                 310                 315                 320 
Val Ala Ile Gly Phe Leu Lys Glu Cys Gly Leu Lys Leu Thr Gln Val
                325                 330                 335     
Ser Pro Arg Gly Ile Asn Ala Ile Phe Glu Arg Leu Arg Asn Ile Leu
            340                 345                 350         
His Glu Ser Glu Ile Asp Lys Arg Val Gln Tyr Met Ile Glu Val Met
        355                 360                 365             
Phe Ala Val Arg Lys Asp Gly Phe Lys Asp His Pro Ile Ile Leu Glu
    370                 375                 380                 
Gly Leu Asp Leu Val Glu Glu Asp Asp Gln Phe Thr His Met Leu Pro
385                 390                 395                 400 
Leu Glu Asp Asp Tyr Asn Pro Glu Asp Val Leu Asn Val Phe Lys Met
                405                 410                 415     
Asp Pro Asn Phe Met Glu Asn Glu Glu Lys Tyr Lys Ala Ile Lys Lys
            420                 425                 430         
Glu Ile Leu Asp Glu Gly Asp Thr Asp Ser Asn Thr Asp Gln Asp Ala
        435                 440                 445             
Gly Ser Ser Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Gly Glu Glu
    450                 455                 460                 
Asp Glu Glu Gly Gln Lys Val Thr Ile His Asp Lys Thr Glu Ile Asn
465                 470                 475                 480 
Leu Val Ser Phe Arg Arg Thr Ile Tyr Leu Ala Ile Gln Ser Ser Leu
                485                 490                 495     
Asp Phe Glu Glu Cys Ala His Lys Leu Leu Lys Met Glu Phe Pro Glu
            500                 505                 510         
Ser Gln Thr Lys Glu Leu Cys Asn Met Ile Leu Asp Cys Cys Ala Gln
        515                 520                 525             
Gln Arg Thr Tyr Glu Lys Phe Phe Gly Leu Leu Ala Gly Arg Phe Cys
    530                 535                 540                 
Met Leu Lys Lys Glu Tyr Met Glu Ser Phe Glu Gly Ile Phe Lys Glu
545                 550                 555                 560 
Gln Tyr Asp Thr Ile His Arg Leu Glu Thr Asn Lys Leu Arg Asn Val
                565                 570                 575     
Ala Lys Met Phe Ala His Leu Leu Tyr Thr Asp Ser Leu Pro Trp Ser
            580                 585                 590         
Val Leu Glu Cys Ile Lys Leu Ser Glu Glu Thr Thr Thr Ser Ser Ser
        595                 600                 605             
Arg Ile Phe Val Lys Ile Phe Phe Gln Glu Leu Cys Glu Tyr Met Gly
    610                 615                 620                 
Leu Pro Lys Leu Asn Ala Arg Leu Lys Asp Glu Thr Leu Gln Pro Phe
625                 630                 635                 640 
Phe Glu Gly Leu Leu Pro Arg Asp Asn Pro Arg Asn Thr Arg Phe Ala
                645                 650                 655     
Ile Asn Phe Phe Thr Ser Ile Gly Leu Gly Gly Leu Thr Asp Glu Leu
            660                 665                 670         
Arg Glu His Leu Lys Asn Thr Pro Lys Val Ile Val Ala Gln Lys Pro
        675                 680                 685             
Asp Val Glu Gln Asn Lys Ser Ser Pro Ser Ser Ser Ser Ser Ala Ser
    690                 695                 700                 
Ser Ser Ser Glu Ser Asp Ser Ser Asp Ser Asp Ser Asp Ser Ser Asp
705                 710                 715                 720 
Ser Ser Ser Glu Ser Ser Ser Glu Glu Ser Asp Ser Ser Ser Ile Ser
                725                 730                 735     
Ser His Ser Ser Ala Ser Ala Asn Asp Val Arg Lys Lys Gly His Gly
            740                 745                 750         
Lys Thr Arg Ser Lys Glu Val Asp Lys Leu Ile Arg Asn Gln Gln Thr
        755                 760                 765             
Asn Asp Arg Lys Gln Lys Glu Arg Arg Gln Glu His Gly His Gln Glu
    770                 775                 780                 
Thr Arg Thr Glu Arg Glu Arg Arg Ser Glu Lys His Arg Asp Gln Asn
785                 790                 795                 800 
Ser Ser Gly Ser Asn Trp Arg Asp Pro Ile Thr Lys Tyr Thr Ser Asp
                805                 810                 815     
Lys Asp Val Pro Ser Glu Arg Asn Asn Tyr Ser Arg Val Ala Asn Asp
            820                 825                 830         
Arg Asp Gln Glu Met His Ile Asp Leu Glu Asn Lys His Gly Asp Pro
        835                 840                 845             
Lys Lys Lys Arg Gly Glu Arg Arg Asn Ser Phe Ser Glu Asn Glu Lys
    850                 855                 860                 
His Thr His Arg Ile Lys Asp Ser Glu Asn Phe Arg Arg Lys Asp Arg
865                 870                 875                 880 
Ser Lys Ser Lys Glu Met Asn Arg Lys His Ser Gly Ser Arg Ser Asp
                885                 890                 895     
Glu Asp Arg Tyr Gln Asn Gly Ala Glu Arg Arg Trp Glu Lys Ser Ser
            900                 905                 910         
Arg Tyr Ser Glu Gln Ser Arg Glu Ser Lys Lys Asn Gln Asp Arg Arg
        915                 920                 925             
Arg Glu Lys Ser Pro Ala Lys Gln Lys
    930                 935         


<210> 1007
<211> 1398
<212> PRT
<213> Homo sapiens

<400> 1007
Ser Pro Asn Ala Thr Pro Arg Arg Pro Leu Gln Glu Leu Arg Arg Ala
 1               5                  10                  15      
Glu Leu Val Glu Ile Ile Val Glu Thr Glu Ala Gln Thr Gly Val Ser
            20                  25                  30          
Gly Ile Asn Val Ala Gly Gly Gly Lys Glu Gly Ile Phe Val Arg Glu
        35                  40                  45              
Leu Arg Glu Asp Ser Pro Ala Ala Arg Ser Leu Ser Leu Gln Glu Gly
    50                  55                  60                  
Asp Gln Leu Leu Ser Ala Arg Val Phe Phe Glu Asn Phe Lys Tyr Glu
65                  70                  75                  80  
Asp Ala Leu Arg Leu Leu Gln Cys Ala Glu Pro Tyr Lys Val Ser Phe
                85                  90                  95      
Cys Leu Lys Arg Thr Val Pro Thr Gly Asp Leu Ala Leu Arg Pro Gly
            100                 105                 110         
Thr Val Ser Gly Tyr Glu Ile Lys Gly Pro Arg Ala Lys Val Ala Lys
        115                 120                 125             
Leu Asn Ile Gln Ser Leu Ser Pro Val Lys Lys Lys Lys Met Val Pro
    130                 135                 140                 
Gly Ala Leu Gly Val Pro Ala Asp Leu Ala Pro Val Asp Val Glu Phe
145                 150                 155                 160 
Ser Phe Pro Lys Phe Ser Arg Leu Arg Arg Gly Leu Lys Ala Glu Ala
                165                 170                 175     
Val Lys Gly Pro Val Pro Ala Ala Pro Ala Arg Arg Arg Leu Gln Leu
            180                 185                 190         
Pro Arg Leu Arg Val Arg Glu Val Ala Glu Glu Ala Gln Ala Ala Arg
        195                 200                 205             
Leu Ala Ala Ala Ala Pro Pro Pro Arg Lys Ala Lys Val Glu Ala Glu
    210                 215                 220                 
Val Ala Ala Gly Ala Arg Phe Thr Ala Pro Gln Val Glu Leu Val Gly
225                 230                 235                 240 
Pro Arg Leu Pro Gly Ala Glu Val Gly Val Pro Gln Val Ser Ala Pro
                245                 250                 255     
Lys Ala Ala Pro Ser Ala Glu Ala Ala Gly Gly Phe Ala Leu His Leu
            260                 265                 270         
Pro Thr Leu Gly Leu Gly Ala Pro Ala Pro Pro Ala Val Glu Ala Pro
        275                 280                 285             
Ala Val Gly Ile Gln Val Pro Gln Val Glu Leu Pro Ala Leu Pro Ser
    290                 295                 300                 
Leu Pro Thr Leu Pro Thr Leu Pro Cys Leu Glu Thr Arg Glu Gly Ala
305                 310                 315                 320 
Val Ser Val Val Val Pro Thr Leu Asp Val Ala Ala Pro Thr Val Gly
                325                 330                 335     
Val Asp Leu Ala Leu Pro Gly Ala Glu Val Glu Ala Arg Gly Glu Ala
            340                 345                 350         
Pro Glu Val Ala Leu Lys Met Pro Arg Leu Ser Phe Pro Arg Phe Gly
        355                 360                 365             
Ala Arg Ala Lys Glu Val Ala Glu Ala Lys Val Ala Lys Val Ser Pro
    370                 375                 380                 
Glu Ala Arg Val Lys Gly Pro Arg Leu Arg Met Pro Thr Phe Gly Leu
385                 390                 395                 400 
Ser Leu Leu Glu Pro Arg Pro Ala Ala Pro Glu Val Val Glu Ser Lys
                405                 410                 415     
Leu Lys Leu Pro Thr Ile Lys Met Pro Ser Leu Gly Ile Gly Val Ser
            420                 425                 430         
Gly Pro Glu Val Lys Val Pro Lys Gly Pro Glu Val Lys Leu Pro Lys
        435                 440                 445             
Ala Pro Glu Val Lys Leu Pro Lys Val Pro Glu Ala Ala Leu Pro Glu
    450                 455                 460                 
Val Arg Leu Pro Glu Val Glu Leu Pro Lys Val Ser Glu Met Lys Leu
465                 470                 475                 480 
Pro Lys Val Pro Glu Met Ala Val Pro Glu Val Arg Leu Pro Glu Val
                485                 490                 495     
Glu Leu Pro Lys Val Ser Glu Met Lys Leu Pro Lys Val Pro Glu Met
            500                 505                 510         
Ala Val Pro Glu Val Arg Leu Pro Glu Val Gln Leu Leu Lys Val Ser
        515                 520                 525             
Glu Met Lys Leu Pro Lys Val Pro Glu Met Ala Val Pro Glu Val Arg
    530                 535                 540                 
Leu Pro Glu Val Gln Leu Pro Lys Val Ser Glu Met Lys Leu Pro Glu
545                 550                 555                 560 
Val Ser Glu Val Ala Val Pro Glu Val Arg Leu Pro Glu Val Gln Leu
                565                 570                 575     
Pro Lys Val Pro Glu Met Lys Val Pro Glu Met Lys Leu Pro Lys Val
            580                 585                 590         
Pro Glu Met Lys Leu Pro Glu Met Lys Leu Pro Glu Val Gln Leu Pro
        595                 600                 605             
Lys Val Pro Glu Met Ala Val Pro Asp Val His Leu Pro Glu Val Gln
    610                 615                 620                 
Leu Pro Lys Val Pro Glu Met Lys Leu Pro Glu Met Lys Leu Pro Glu
625                 630                 635                 640 
Val Lys Leu Pro Lys Val Pro Glu Met Ala Val Pro Asp Val His Leu
                645                 650                 655     
Pro Glu Val Gln Leu Pro Lys Val Pro Glu Met Lys Leu Pro Lys Met
            660                 665                 670         
Pro Glu Met Ala Val Pro Glu Val Arg Leu Pro Glu Val Gln Leu Pro
        675                 680                 685             
Lys Val Ser Glu Met Lys Leu Pro Lys Val Pro Glu Met Ala Val Pro
    690                 695                 700                 
Asp Val His Leu Pro Glu Val Gln Leu Pro Lys Val Cys Glu Met Lys
705                 710                 715                 720 
Val Pro Asp Met Lys Leu Pro Glu Ile Lys Leu Pro Lys Val Pro Glu
                725                 730                 735     
Met Ala Val Pro Asp Val His Leu Pro Glu Val Gln Leu Pro Lys Val
            740                 745                 750         
Ser Glu Ile Arg Leu Pro Glu Met Gln Val Pro Lys Val Pro Asp Val
        755                 760                 765             
His Leu Pro Lys Ala Pro Glu Val Lys Leu Pro Arg Ala Pro Glu Val
    770                 775                 780                 
Gln Leu Lys Ala Thr Lys Ala Glu Gln Ala Glu Gly Met Glu Phe Gly
785                 790                 795                 800 
Phe Lys Met Pro Lys Met Thr Met Pro Lys Leu Gly Arg Ala Glu Ser
                805                 810                 815     
Pro Ser Arg Gly Lys Pro Gly Glu Ala Gly Ala Glu Val Ser Gly Lys
            820                 825                 830         
Leu Val Thr Leu Pro Cys Leu Gln Pro Glu Val Asp Gly Glu Ala His
        835                 840                 845             
Val Gly Val Pro Ser Leu Thr Leu Pro Ser Val Glu Leu Asp Leu Pro
    850                 855                 860                 
Gly Ala Leu Gly Leu Gln Gly Gln Val Pro Ala Ala Lys Met Gly Lys
865                 870                 875                 880 
Gly Glu Arg Ala Glu Gly Pro Glu Val Ala Ala Gly Val Arg Glu Val
                885                 890                 895     
Gly Phe Arg Val Pro Ser Val Glu Ile Val Thr Pro Gln Leu Pro Ala
            900                 905                 910         
Val Glu Ile Glu Glu Gly Arg Leu Glu Met Ile Glu Thr Lys Val Lys
        915                 920                 925             
Pro Ser Ser Lys Phe Ser Leu Pro Lys Phe Gly Leu Ser Gly Pro Lys
    930                 935                 940                 
Val Ala Lys Ala Glu Ala Glu Gly Ala Gly Arg Ala Thr Lys Leu Lys
945                 950                 955                 960 
Val Ser Lys Phe Ala Ile Ser Leu Pro Lys Ala Arg Val Gly Ala Glu
                965                 970                 975     
Ala Glu Ala Lys Gly Ala Gly Glu Ala Gly Leu Leu Pro Ala Leu Asp
            980                 985                 990         
Leu Ser Ile Pro Gln Leu Ser Leu Asp Ala His Leu Pro Ser Gly Lys
        995                 1000                1005            
Val Glu Val Ala Gly Ala Asp Leu Lys Phe Lys Gly Pro Arg Phe Ala
    1010                1015                1020                
Leu Pro Lys Phe Gly Val Arg Gly Arg Asp Thr Glu Ala Ala Glu Leu
1025                1030                1035                1040
Val Pro Gly Val Ala Glu Leu Glu Gly Lys Gly Trp Gly Trp Asp Gly
                1045                1050                1055    
Arg Val Lys Met Pro Lys Leu Lys Val Ser Thr Ala Gly Gln Val Val
            1060                1065                1070        
Thr Glu Gly His Asp Ala Gly Leu Arg Met Pro Pro Leu Gly Ile Ser
        1075                1080                1085            
Leu Pro Gln Val Glu Leu Thr Gly Phe Gly Glu Ala Gly Thr Pro Gly
    1090                1095                1100                
Gln Gln Ala Gln Ser Thr Val Pro Ser Ala Glu Gly Thr Ala Gly Tyr
1105                1110                1115                1120
Arg Val Gln Val Pro Gln Val Thr Leu Ser Leu Pro Gly Ala Gln Val
                1125                1130                1135    
Ala Gly Gly Glu Leu Leu Val Gly Glu Gly Val Phe Lys Met Pro Thr
            1140                1145                1150        
Val Thr Val Pro Gln Leu Glu Leu Asp Val Gly Leu Ser Arg Glu Ala
        1155                1160                1165            
Gln Ala Gly Glu Ala Ala Thr Gly Glu Gly Gly Leu Arg Leu Lys Leu
    1170                1175                1180                
Pro Thr Leu Gly Ala Arg Ala Arg Val Gly Gly Glu Gly Ala Glu Glu
1185                1190                1195                1200
Gln Pro Pro Gly Ala Glu Arg Thr Phe Cys Leu Ser Leu Pro Asp Val
                1205                1210                1215    
Glu Leu Ser Pro Ser Gly Gly Asn His Ala Glu Tyr Gln Val Ala Glu
            1220                1225                1230        
Gly Glu Gly Glu Ala Gly His Lys Leu Lys Val Arg Leu Pro Arg Phe
        1235                1240                1245            
Gly Leu Val Arg Ala Lys Glu Gly Ala Glu Glu Gly Glu Lys Ala Lys
    1250                1255                1260                
Ser Pro Lys Leu Arg Leu Pro Arg Val Gly Phe Ser Gln Ser Glu Met
1265                1270                1275                1280
Val Thr Gly Glu Gly Ser Pro Ser Pro Glu Glu Glu Glu Glu Glu Glu
                1285                1290                1295    
Glu Glu Gly Ser Gly Glu Gly Ala Ser Gly Arg Arg Gly Arg Val Arg
            1300                1305                1310        
Val Arg Leu Pro Arg Val Gly Leu Ala Ala Pro Ser Lys Ala Ser Arg
        1315                1320                1325            
Gly Gln Glu Gly Asp Ala Ala Pro Lys Ser Pro Val Arg Glu Lys Ser
    1330                1335                1340                
Pro Lys Phe Arg Phe Pro Arg Val Ser Leu Ser Pro Lys Ala Arg Ser
1345                1350                1355                1360
Gly Ser Gly Asp Gln Glu Glu Gly Gly Leu Arg Val Arg Leu Pro Ser
                1365                1370                1375    
Val Gly Phe Ser Glu Thr Gly Ala Pro Gly Pro Ala Arg Met Glu Gly
            1380                1385                1390        
Ala Gln Ala Ala Ala Val
        1395            


<210> 1008
<211> 1284
<212> PRT
<213> Homo sapiens

<400> 1008
Ala Gly Pro Cys Leu Met Ala Ser Ser Asn Pro Pro Pro Gln Pro Ala
 1               5                  10                  15      
Ile Gly Asp Gln Leu Val Pro Gly Val Pro Gly Pro Ser Ser Glu Ala
            20                  25                  30          
Glu Asp Asp Pro Gly Glu Ala Phe Glu Phe Asp Asp Ser Asp Asp Glu
        35                  40                  45              
Glu Asp Thr Ser Ala Ala Leu Gly Val Pro Ser Leu Ala Pro Glu Arg
    50                  55                  60                  
Asp Thr Asp Pro Pro Leu Ile His Leu Asp Ser Ile Pro Val Thr Asp
65                  70                  75                  80  
Pro Asp Pro Ala Ala Ala Pro Pro Gly Thr Gly Val Pro Ala Trp Val
                85                  90                  95      
Ser Asn Gly Asp Ala Ala Asp Ala Ala Phe Ser Gly Ala Arg His Ser
            100                 105                 110         
Ser Trp Lys Arg Lys Ser Ser Arg Arg Ile Asp Arg Phe Thr Phe Pro
        115                 120                 125             
Ala Leu Glu Glu Asp Val Ile Tyr Asp Asp Val Pro Cys Glu Ser Pro
    130                 135                 140                 
Asp Ala His Gln Pro Gly Ala Glu Arg Asn Leu Leu Tyr Glu Asp Ala
145                 150                 155                 160 
His Arg Ala Gly Ala Pro Arg Gln Ala Glu Asp Leu Gly Trp Ser Ser
                165                 170                 175     
Ser Glu Phe Glu Ser Tyr Ser Glu Asp Ser Gly Glu Glu Ala Lys Pro
            180                 185                 190         
Glu Val Glu Val Glu Pro Ala Lys His Arg Val Ser Phe Gln Pro Lys
        195                 200                 205             
Leu Ser Pro Asp Leu Thr Arg Leu Lys Glu Arg Tyr Ala Arg Thr Lys
    210                 215                 220                 
Arg Asp Ile Leu Ala Leu Arg Val Gly Gly Arg Asp Met Gln Glu Leu
225                 230                 235                 240 
Lys His Lys Tyr Asp Cys Lys Met Thr Gln Leu Met Lys Ala Ala Lys
                245                 250                 255     
Ser Gly Thr Lys Asp Gly Leu Glu Lys Thr Arg Met Ala Val Met Arg
            260                 265                 270         
Lys Val Ser Phe Leu His Arg Lys Asp Val Leu Gly Asp Ser Glu Glu
        275                 280                 285             
Glu Asp Met Gly Leu Leu Glu Val Ser Val Ser Asp Ile Lys Pro Pro
    290                 295                 300                 
Ala Pro Glu Leu Gly Pro Met Pro Glu Gly Leu Ser Pro Gln Gln Val
305                 310                 315                 320 
Val Arg Arg His Ile Leu Gly Ser Ile Val Gln Ser Glu Gly Ser Tyr
                325                 330                 335     
Val Glu Ser Leu Lys Arg Ile Leu Gln Asp Tyr Arg Asn Pro Leu Met
            340                 345                 350         
Glu Met Glu Pro Lys Ala Leu Ser Ala Arg Lys Cys Gln Val Val Phe
        355                 360                 365             
Phe Arg Val Lys Glu Ile Leu His Cys His Ser Met Phe Gln Ile Ala
    370                 375                 380                 
Leu Ser Ser Arg Val Ala Glu Trp Asp Ser Thr Glu Lys Ile Gly Asp
385                 390                 395                 400 
Leu Phe Val Ala Ser Phe Ser Lys Ser Met Val Leu Asp Val Tyr Ser
                405                 410                 415     
Asp Tyr Val Asn Asn Phe Thr Ser Ala Met Ser Ile Ile Lys Lys Ala
            420                 425                 430         
Cys Leu Thr Lys Pro Ala Phe Leu Glu Phe Leu Lys Arg Arg Gln Val
        435                 440                 445             
Cys Ser Pro Asp Arg Val Thr Leu Tyr Gly Leu Met Val Lys Pro Ile
    450                 455                 460                 
Gln Arg Phe Pro Gln Phe Ile Leu Leu Leu Gln Asp Met Leu Lys Asn
465                 470                 475                 480 
Thr Pro Arg Gly His Pro Asp Arg Leu Ser Leu Gln Leu Ala Leu Thr
                485                 490                 495     
Glu Leu Glu Thr Leu Ala Glu Lys Leu Asn Glu Gln Lys Arg Leu Ala
            500                 505                 510         
Asp Gln Val Ala Glu Ile Gln Gln Leu Thr Lys Ser Val Ser Asp Arg
        515                 520                 525             
Ser Ser Leu Asn Lys Leu Leu Thr Ser Gly Gln Arg Gln Leu Leu Leu
    530                 535                 540                 
Cys Glu Thr Leu Thr Glu Thr Val Tyr Gly Asp Arg Gly Gln Leu Ile
545                 550                 555                 560 
Lys Ser Lys Glu Arg Arg Val Phe Leu Leu Asn Asp Met Leu Val Cys
                565                 570                 575     
Ala Asn Ile Asn Phe Lys Pro Ala Asn His Arg Gly Gln Leu Glu Ile
            580                 585                 590         
Ser Ser Leu Val Pro Leu Gly Pro Lys Tyr Val Val Lys Trp Asn Thr
        595                 600                 605             
Ala Leu Pro Gln Val Gln Val Val Glu Val Gly Gln Asp Gly Gly Thr
    610                 615                 620                 
Tyr Asp Lys Asp Asn Val Leu Ile Gln His Ser Gly Ala Lys Lys Ala
625                 630                 635                 640 
Ser Ala Ser Gly Gln Ala Gln Asn Lys Val Tyr Leu Gly Pro Pro Arg
                645                 650                 655     
Leu Phe Gln Glu Leu Gln Asp Leu Gln Lys Asp Leu Ala Val Val Glu
            660                 665                 670         
Gln Ile Thr Leu Leu Ile Ser Thr Leu His Gly Thr Tyr Gln Asn Leu
        675                 680                 685             
Asn Met Thr Val Ala Gln Asp Trp Cys Leu Ala Leu Gln Arg Leu Met
    690                 695                 700                 
Arg Val Lys Glu Glu Glu Ile His Ser Ala Asn Lys Cys Arg Leu Arg
705                 710                 715                 720 
Leu Leu Leu Pro Gly Lys Pro Asp Lys Ser Gly Arg Pro Ile Ser Phe
                725                 730                 735     
Met Val Val Phe Ile Thr Pro Asn Pro Leu Ser Lys Ile Ser Trp Val
            740                 745                 750         
Asn Arg Leu His Leu Ala Lys Ile Gly Leu Arg Glu Glu Asn Gln Pro
        755                 760                 765             
Gly Trp Leu Cys Pro Asp Glu Asp Lys Lys Ser Lys Ala Pro Phe Trp
    770                 775                 780                 
Cys Pro Ile Leu Ala Cys Cys Ile Pro Ala Phe Ser Ser Arg Ala Leu
785                 790                 795                 800 
Ser Leu Gln Leu Gly Ala Leu Val His Ser Pro Val Asn Cys Pro Leu
                805                 810                 815     
Leu Gly Phe Ser Ala Val Ser Thr Ser Leu Pro Gln Gly Tyr Leu Trp
            820                 825                 830         
Val Gly Gly Gly Gln Glu Gly Ala Gly Gly Gln Val Glu Ile Phe Ser
        835                 840                 845             
Leu Asn Arg Pro Ser Pro Arg Thr Val Lys Ser Phe Pro Leu Ala Ala
    850                 855                 860                 
Pro Val Leu Cys Met Glu Tyr Ile Pro Glu Leu Glu Glu Glu Ala Glu
865                 870                 875                 880 
Ser Arg Asp Glu Ser Pro Thr Val Ala Asp Pro Ser Ala Thr Val His
                885                 890                 895     
Pro Thr Ile Cys Leu Gly Leu Gln Asp Gly Ser Ile Leu Leu Tyr Ser
            900                 905                 910         
Ser Val Asp Thr Gly Thr Gln Cys Leu Val Ser Cys Arg Ser Pro Gly
        915                 920                 925             
Leu Gln Pro Val Leu Cys Leu Arg His Ser Pro Phe His Leu Leu Ala
    930                 935                 940                 
Gly Leu Gln Asp Gly Thr Leu Ala Ala Tyr Pro Arg Thr Ser Gly Gly
945                 950                 955                 960 
Val Leu Trp Asp Leu Glu Ser Pro Pro Val Cys Leu Thr Val Gly Pro
                965                 970                 975     
Gly Pro Val Arg Thr Leu Leu Ser Leu Glu Asp Ala Val Trp Ala Ser
            980                 985                 990         
Cys Gly Pro Arg Val Thr Val Leu Glu Ala Thr Thr Leu Gln Pro Gln
        995                 1000                1005            
Gln Ser Phe Glu Ala His Gln Asp Glu Ala Val Ser Val Thr His Met
    1010                1015                1020                
Val Lys Ala Gly Ser Gly Val Trp Met Ala Phe Ser Ser Gly Thr Ser
1025                1030                1035                1040
Ile Arg Leu Phe His Thr Glu Thr Leu Glu His Leu Gln Glu Ile Asn
                1045                1050                1055    
Ile Ala Thr Arg Thr Thr Phe Leu Leu Pro Gly Gln Lys His Leu Cys
            1060                1065                1070        
Val Thr Ser Leu Leu Ile Cys Gln Gly Leu Leu Trp Val Gly Thr Asp
        1075                1080                1085            
Gln Gly Val Ile Val Leu Leu Pro Val Pro Arg Leu Glu Gly Ile Pro
    1090                1095                1100                
Lys Ile Thr Gly Lys Gly Met Val Ser Leu Asn Gly His Cys Gly Pro
1105                1110                1115                1120
Val Ala Phe Leu Ala Val Ala Thr Ser Ile Leu Ala Pro Asp Ile Leu
                1125                1130                1135    
Arg Ser Asp Gln Glu Glu Ala Glu Gly Pro Arg Ala Glu Glu Asp Lys
            1140                1145                1150        
Pro Asp Gly Gln Ala His Glu Pro Met Pro Asp Ser His Val Gly Arg
        1155                1160                1165            
Glu Leu Thr Arg Lys Lys Gly Ile Leu Leu Gln Tyr Arg Leu Arg Ser
    1170                1175                1180                
Thr Ala His Leu Pro Gly Pro Leu Leu Ser Met Arg Glu Pro Ala Pro
1185                1190                1195                1200
Ala Asp Gly Ala Ala Leu Glu His Ser Glu Glu Asp Gly Ser Ile Tyr
                1205                1210                1215    
Glu Met Ala Asp Asp Pro Asp Val Trp Val Arg Ser Arg Pro Cys Ala
            1220                1225                1230        
Arg Asp Ala His Arg Lys Glu Ile Cys Ser Val Ala Ile Ile Ser Gly
        1235                1240                1245            
Gly Gln Gly Tyr Arg Asn Phe Gly Ser Ala Leu Gly Ser Ser Gly Arg
    1250                1255                1260                
Gln Ala Pro Cys Gly Glu Thr Asp Ser Thr Leu Leu Ile Trp Gln Val
1265                1270                1275                1280
Pro Leu Met Leu
                


<210> 1009
<211> 1329
<212> PRT
<213> Homo sapiens

<400> 1009
Glu Cys Ser Arg Val Thr Val Thr Glu His Trp Ser Lys Val Phe Pro
 1               5                  10                  15      
Lys Gly Gln Gly Ser Gln Glu His Leu Leu Lys Leu Met Thr Met Gly
            20                  25                  30          
Asp Met Lys Thr Pro Asp Phe Asp Asp Leu Leu Ala Ala Phe Asp Ile
        35                  40                  45              
Pro Asp Met Val Asp Pro Lys Ala Ala Ile Glu Ser Gly His Asp Asp
    50                  55                  60                  
His Glu Ser His Met Lys Gln Asn Ala His Gly Glu Asp Asp Ser His
65                  70                  75                  80  
Ala Pro Ser Ser Ser Asp Val Gly Val Ser Val Ile Val Lys Asn Val
                85                  90                  95      
Arg Asn Ile Asp Ser Ser Glu Gly Gly Glu Lys Asp Gly His Asn Pro
            100                 105                 110         
Thr Gly Asn Gly Leu His Asn Gly Phe Leu Thr Ala Ser Ser Leu Asp
        115                 120                 125             
Ser Tyr Ser Lys Asp Gly Ala Lys Ser Leu Lys Gly Asp Val Pro Ala
    130                 135                 140                 
Ser Glu Val Thr Leu Lys Asp Ser Thr Phe Ser Gln Phe Ser Pro Ile
145                 150                 155                 160 
Ser Ser Ala Glu Glu Phe Asp Asp Asp Glu Lys Ile Glu Val Asp Asp
                165                 170                 175     
Pro Pro Asp Lys Glu Asp Met Arg Ser Ser Phe Arg Ser Asn Val Leu
            180                 185                 190         
Thr Gly Ser Ala Pro Gln Gln Asp Tyr Asp Lys Leu Lys Ala Leu Gly
        195                 200                 205             
Gly Glu Asn Ser Ser Lys Thr Gly Leu Ser Thr Ser Gly Asn Val Glu
    210                 215                 220                 
Lys Asn Lys Ala Val Lys Arg Glu Thr Glu Ala Ser Ser Ile Asn Leu
225                 230                 235                 240 
Ser Val Tyr Glu Pro Phe Lys Val Arg Lys Ala Glu Asp Lys Leu Lys
                245                 250                 255     
Glu Ser Ser Asp Lys Val Leu Glu Asn Arg Val Leu Asp Gly Lys Leu
            260                 265                 270         
Ser Ser Glu Lys Asn Asp Thr Ser Leu Pro Ser Val Ala Pro Ser Lys
        275                 280                 285             
Thr Lys Ser Ser Ser Lys Leu Ser Ser Cys Ile Ala Ala Ile Ala Ala
    290                 295                 300                 
Leu Ser Ala Lys Lys Ala Ala Ser Asp Ser Cys Lys Glu Pro Val Ala
305                 310                 315                 320 
Asn Ser Arg Glu Ser Ser Pro Leu Pro Lys Glu Val Asn Asp Ser Pro
                325                 330                 335     
Arg Ala Ala Asp Lys Ser Pro Glu Ser Gln Asn Leu Ile Asp Gly Thr
            340                 345                 350         
Lys Lys Pro Ser Leu Lys Gln Pro Asp Ser Pro Arg Ser Ile Ser Ser
        355                 360                 365             
Glu Asn Ser Ser Lys Gly Ser Pro Ser Ser Pro Ala Gly Ser Thr Pro
    370                 375                 380                 
Ala Ile Pro Lys Val Arg Ile Lys Thr Ile Lys Thr Ser Ser Gly Glu
385                 390                 395                 400 
Ile Lys Arg Thr Val Thr Arg Val Leu Pro Glu Val Asp Leu Asp Ser
                405                 410                 415     
Gly Lys Lys Pro Ser Glu Gln Thr Ala Ser Val Met Ala Ser Val Thr
            420                 425                 430         
Ser Leu Leu Ser Ser Pro Ala Ser Ala Ala Val Leu Ser Ser Pro Pro
        435                 440                 445             
Arg Ala Pro Leu Gln Ser Ala Val Val Thr Asn Ala Val Ser Pro Ala
    450                 455                 460                 
Glu Leu Thr Pro Lys Gln Val Thr Ile Lys Pro Val Ala Thr Ala Phe
465                 470                 475                 480 
Leu Pro Val Ser Ala Val Lys Thr Ala Gly Ser Gln Val Ile Asn Leu
                485                 490                 495     
Lys Leu Ala Asn Asn Thr Thr Val Lys Ala Thr Val Ile Ser Ala Ala
            500                 505                 510         
Ser Val Gln Ser Ala Ser Ser Ala Ile Ile Lys Ala Ala Asn Ala Ile
        515                 520                 525             
Gln Gln Gln Thr Val Val Val Pro Ala Ser Ser Leu Ala Asn Ala Lys
    530                 535                 540                 
Leu Val Pro Lys Thr Val His Leu Ala Asn Leu Asn Leu Leu Pro Gln
545                 550                 555                 560 
Gly Ala Gln Ala Thr Ser Glu Leu Arg Gln Val Leu Thr Lys Pro Gln
                565                 570                 575     
Gln Gln Ile Lys Gln Ala Ile Ile Asn Ala Ala Ala Ser Gln Pro Pro
            580                 585                 590         
Lys Lys Val Ser Arg Val Gln Val Val Ser Ser Leu Gln Ser Ser Val
        595                 600                 605             
Val Glu Ala Phe Asn Lys Val Leu Ser Ser Val Asn Pro Val Pro Val
    610                 615                 620                 
Tyr Ile Pro Asn Leu Ser Pro Pro Ala Asn Ala Gly Ile Thr Leu Pro
625                 630                 635                 640 
Thr Arg Gly Tyr Lys Cys Leu Glu Cys Gly Asp Ser Phe Ala Leu Glu
                645                 650                 655     
Lys Ser Leu Thr Gln His Tyr Asp Arg Arg Ser Val Arg Ile Glu Val
            660                 665                 670         
Thr Cys Asn His Cys Thr Lys Asn Leu Val Phe Tyr Asn Lys Cys Ser
        675                 680                 685             
Leu Leu Ser His Ala Arg Gly His Lys Glu Lys Gly Val Val Met Gln
    690                 695                 700                 
Cys Ser His Leu Ile Leu Lys Pro Val Pro Ala Asp Gln Met Ile Val
705                 710                 715                 720 
Ser Pro Ser Ser Asn Thr Ser Thr Ser Thr Ser Thr Leu Gln Ser Pro
                725                 730                 735     
Val Gly Ala Gly Thr His Thr Val Thr Lys Ile Gln Ser Gly Ile Thr
            740                 745                 750         
Gly Thr Val Ile Ser Ala Pro Ser Ser Thr Pro Ile Thr Pro Ala Met
        755                 760                 765             
Pro Leu Asp Glu Asp Pro Ser Lys Leu Cys Arg His Ser Leu Lys Cys
    770                 775                 780                 
Leu Glu Cys Asn Glu Val Phe Gln Asp Glu Thr Ser Leu Ala Thr His
785                 790                 795                 800 
Phe Gln Gln Ala Ala Asp Thr Ser Gly Gln Lys Thr Cys Thr Ile Cys
                805                 810                 815     
Gln Met Leu Leu Pro Asn Gln Cys Ser Tyr Ala Ser His Gln Arg Ile
            820                 825                 830         
His Gln His Lys Ser Pro Tyr Thr Cys Pro Glu Cys Gly Ala Ile Cys
        835                 840                 845             
Arg Ser Val His Phe Gln Thr His Val Thr Lys Asn Cys Leu His Tyr
    850                 855                 860                 
Thr Arg Arg Val Gly Phe Arg Cys Val His Cys Asn Val Val Tyr Ser
865                 870                 875                 880 
Asp Val Ala Ala Leu Lys Ser His Ile Gln Gly Ser His Cys Glu Val
                885                 890                 895     
Phe Tyr Lys Cys Pro Ile Cys Pro Met Ala Phe Lys Ser Ala Pro Ser
            900                 905                 910         
Thr His Ser His Ala Tyr Thr Gln His Pro Gly Ile Lys Ile Gly Glu
        915                 920                 925             
Pro Lys Ile Ile Tyr Lys Cys Ser Met Cys Asp Thr Val Phe Thr Leu
    930                 935                 940                 
Gln Thr Leu Leu Tyr Arg His Phe Asp Gln His Ile Glu Asn Gln Lys
945                 950                 955                 960 
Val Ser Val Phe Lys Cys Pro Asp Cys Ser Leu Leu Tyr Ala Gln Lys
                965                 970                 975     
Gln Leu Met Met Asp His Ile Lys Ser Met His Gly Thr Leu Lys Ser
            980                 985                 990         
Ile Glu Gly Pro Pro Asn Leu Gly Ile Asn Leu Pro Leu Ser Ile Lys
        995                 1000                1005            
Pro Ala Thr Gln Asn Ser Ala Asn Gln Asn Lys Glu Asp Thr Lys Ser
    1010                1015                1020                
Met Asn Gly Lys Glu Lys Leu Glu Lys Lys Ser Pro Ser Pro Val Lys
1025                1030                1035                1040
Lys Ser Met Glu Thr Lys Lys Val Ala Ser Pro Gly Trp Thr Cys Trp
                1045                1050                1055    
Glu Cys Asp Cys Leu Phe Met Gln Arg Asp Val Tyr Ile Ser His Val
            1060                1065                1070        
Arg Lys Glu His Gly Lys Gln Met Lys Lys His Pro Cys Arg Gln Cys
        1075                1080                1085            
Asp Lys Ser Phe Ser Ser Ser His Ser Leu Cys Arg His Asn Arg Ile
    1090                1095                1100                
Lys His Lys Gly Ile Arg Lys Val Tyr Ala Cys Ser His Cys Pro Asp
1105                1110                1115                1120
Ser Arg Arg Thr Phe Thr Lys Arg Leu Met Leu Glu Lys His Val Gln
                1125                1130                1135    
Leu Met His Gly Ile Lys Asp Pro Asp Leu Lys Glu Met Thr Asp Ala
            1140                1145                1150        
Thr Asn Glu Glu Glu Thr Glu Ile Lys Glu Asp Thr Lys Val Pro Ser
        1155                1160                1165            
Pro Lys Arg Lys Leu Glu Glu Pro Val Leu Glu Phe Arg Pro Pro Arg
    1170                1175                1180                
Gly Ala Ile Thr Gln Pro Leu Lys Lys Leu Lys Ile Asn Val Phe Lys
1185                1190                1195                1200
Val His Lys Cys Ala Val Cys Gly Phe Thr Thr Glu Asn Leu Leu Gln
                1205                1210                1215    
Phe His Glu His Ile Pro Gln His Lys Ser Asp Gly Ser Ser Tyr Gln
            1220                1225                1230        
Cys Arg Glu Cys Gly Leu Cys Tyr Thr Ser His Val Ser Leu Ser Arg
        1235                1240                1245            
His Leu Phe Ile Val His Lys Leu Lys Glu Pro Gln Pro Val Ser Lys
    1250                1255                1260                
Gln Asn Gly Ala Gly Glu Asp Asn Gln Gln Glu Asn Lys Pro Ser His
1265                1270                1275                1280
Glu Asp Glu Ser Pro Asp Gly Ala Val Ser Asp Arg Lys Cys Lys Val
                1285                1290                1295    
Cys Ala Lys Thr Phe Glu Thr Glu Ala Ala Leu Asn Thr His Met Arg
            1300                1305                1310        
Thr His Gly Met Ala Phe Ile Lys Ser Lys Arg Met Ser Ser Ala Glu
        1315                1320                1325            
Lys
    


<210> 1010
<211> 1457
<212> PRT
<213> Homo sapiens

<400> 1010
Lys Thr Asn Gly Asp Gly Ala Ala Glu Gly Ser Met Ala Glu Ala Val
 1               5                  10                  15      
Lys Pro Gln Arg Arg Ala Lys Ala Lys Ala Ser Arg Thr Lys Thr Lys
            20                  25                  30          
Glu Lys Lys Lys Tyr Glu Thr Pro Gln Arg Glu Glu Ser Ser Glu Val
        35                  40                  45              
Ser Leu Pro Lys Thr Ser Arg Glu Gln Glu Ile Pro Ser Leu Ala Cys
    50                  55                  60                  
Glu Phe Lys Gly Asp His Leu Lys Val Val Thr Asp Ser Gln Leu Gln
65                  70                  75                  80  
Asp Asp Ala Ser Gly Gln Asn Glu Ser Glu Met Phe Asp Val Pro Leu
                85                  90                  95      
Thr Ser Leu Thr Ile Ser Asn Glu Glu Ser Leu Thr Cys Asn Thr Glu
            100                 105                 110         
Pro Pro Lys Glu Gly Gly Glu Ala Arg Pro Cys Val Gly Asp Ser Ala
        115                 120                 125             
Val Thr Pro Lys Val His Pro Gly Asp Asn Val Gly Thr Lys Val Glu
    130                 135                 140                 
Thr Pro Lys Asn Phe Thr Glu Val Glu Glu Asn Met Ser Val Gln Gly
145                 150                 155                 160 
Gly Leu Ser Glu Ser Ala Pro Gln Ser Asn Phe Ser Tyr Thr Gln Pro
                165                 170                 175     
Ala Met Glu Asn Ile Gln Val Arg Glu Thr Gln Asn Ser Lys Glu Asp
            180                 185                 190         
Glu Gln Gly Leu Val Cys Ser Ser Glu Val Pro Gln Asn Val Gly Leu
        195                 200                 205             
Gln Ser Ser Cys Pro Ala Lys His Gly Phe Gln Thr Pro Arg Val Lys
    210                 215                 220                 
Lys Leu Tyr Pro Gln Leu Pro Ala Glu Ile Ala Gly Glu Ala Pro Ala
225                 230                 235                 240 
Leu Val Ala Val Lys Pro Leu Leu Arg Ser Glu Arg Leu Tyr Pro Glu
                245                 250                 255     
Leu Pro Ser Gln Leu Glu Leu Val Pro Phe Thr Lys Glu Gln Leu Lys
            260                 265                 270         
Ile Leu Glu Pro Gly Ser Trp Leu Glu Asn Val Glu Ser Tyr Leu Glu
        275                 280                 285             
Glu Phe Asp Ser Met Ala His Gln Asp Arg His Glu Phe Tyr Glu Leu
    290                 295                 300                 
Leu Leu Asn Tyr Ser Arg Cys Arg Lys Gln Leu Leu Leu Ala Glu Ala
305                 310                 315                 320 
Glu Leu Leu Thr Leu Thr Ser Asp Cys Gln Asn Ala Lys Ser Arg Leu
                325                 330                 335     
Trp Gln Phe Lys Glu Glu Gln Met Ser Val Gln Gly Ile Cys Ala Asp
            340                 345                 350         
Gln Val Lys Val Phe Ser Tyr His Arg Tyr Gln Arg Val Glu Met Asn
        355                 360                 365             
Glu Asn Ala Leu Val Glu Leu Lys Lys Leu Phe Asp Ala Lys Ser Glu
    370                 375                 380                 
His Leu His Gln Thr Leu Ala Leu His Ser Tyr Thr Ser Val Leu Ser
385                 390                 395                 400 
Arg Leu Gln Val Glu Ser Tyr Ile Tyr Ala Leu Leu Ser Ser Ser Ala
                405                 410                 415     
Val Leu Arg Ser Ser Ala Ile His Gln Gln Gly Arg Ala Ser Lys Gln
            420                 425                 430         
Thr Glu Ser Ile Pro Ser Asp Leu Cys Gln Leu Lys Glu Cys Ile Ser
        435                 440                 445             
Val Leu Phe Met Phe Thr Arg Arg Val Asn Glu Asp Thr Gln Phe His
    450                 455                 460                 
Asp Asp Ile Leu Leu Trp Leu Gln Lys Leu Val Ser Val Leu Gln Arg
465                 470                 475                 480 
Val Gly Cys Pro Gly Asp His Leu Phe Leu Leu Asn His Ile Leu Arg
                485                 490                 495     
Cys Pro Ala Gly Val Ser Lys Trp Ala Val Pro Phe Ile Gln Ile Lys
            500                 505                 510         
Val Leu His Asn Pro Ser Gly Val Phe His Phe Met Gln Ser Leu Ala
        515                 520                 525             
Leu Leu Met Ser Pro Val Lys Asn Arg Ala Glu Phe Met Cys His Met
    530                 535                 540                 
Lys Pro Ser Glu Arg Lys Pro Ser Ser Ser Gly Pro Gly Ser Gly Thr
545                 550                 555                 560 
Trp Thr Leu Val Asp Glu Gly Gly Glu Glu Asp Glu Asp Pro Glu Thr
                565                 570                 575     
Ser Trp Ile Leu Leu Asn Glu Asp Asp Leu Val Thr Ile Leu Ala Gln
            580                 585                 590         
Phe Pro Phe His Glu Leu Phe Gln His Leu Leu Gly Phe Lys Ala Lys
        595                 600                 605             
Gly Asp Tyr Leu Pro Glu Thr Thr Arg Pro Gln Glu Met Met Lys Ile
    610                 615                 620                 
Phe Ala Phe Ala Asn Ser Leu Val Glu Leu Leu Ala Val Gly Leu Glu
625                 630                 635                 640 
Thr Phe Asn Arg Ala Arg Tyr Arg Gln Phe Val Lys Arg Ile Gly Tyr
                645                 650                 655     
Met Ile Arg Met Thr Leu Gly Tyr Val Ser Asp His Trp Ala Gln Tyr
            660                 665                 670         
Val Ser His Asn Gln Gly Ser Gly Leu Ala Gln Gln Pro Tyr Ser Met
        675                 680                 685             
Glu Lys Leu Gln Val Glu Phe Asp Glu Leu Phe Leu Arg Ala Val Leu
    690                 695                 700                 
His Val Leu Lys Ala Lys Arg Leu Gly Ile Trp Leu Phe Met Ser Glu
705                 710                 715                 720 
Met Pro Phe Gly Thr Leu Ser Val Gln Met Leu Trp Lys Leu Phe Tyr
                725                 730                 735     
Leu Met His Gln Val Glu Ser Glu Asn Leu Gln Gln Leu Ser Ser Ser
            740                 745                 750         
Leu Gln Pro Ala Gln Cys Lys Gln Gln Leu Gln Asp Pro Glu His Phe
        755                 760                 765             
Thr Asn Phe Glu Lys Cys Leu Ser Ser Met Asn Ser Ser Glu Glu Ile
    770                 775                 780                 
Cys Leu Leu Thr Thr Phe Ala Gln Met Ala Gln Ala Arg Arg Thr Asn
785                 790                 795                 800 
Val Asp Glu Asp Phe Ile Lys Ile Ile Val Leu Glu Ile Tyr Glu Val
                805                 810                 815     
Ser Tyr Val Thr Leu Ser Thr Arg Glu Thr Phe Ser Lys Val Gly Arg
            820                 825                 830         
Glu Leu Leu Gly Thr Ile Thr Ala Val His Pro Glu Ile Ile Ser Val
        835                 840                 845             
Leu Leu Asp Arg Val Gln Glu Thr Ile Asp Gln Val Gly Met Val Ser
    850                 855                 860                 
Leu Tyr Leu Phe Lys Glu Leu Pro Leu Tyr Leu Trp Gln Pro Ser Ala
865                 870                 875                 880 
Ser Glu Ile Ala Val Ile Arg Asp Trp Leu Leu Asn Tyr Asn Leu Thr
                885                 890                 895     
Val Val Lys Asn Lys Leu Ala Cys Val Ile Leu Glu Gly Leu Asn Trp
            900                 905                 910         
Gly Phe Ala Lys Gln Ala Thr Leu His Leu Asp Gln Ala Val His Ala
        915                 920                 925             
Glu Val Ala Leu Met Val Leu Glu Ala Tyr Gln Lys Tyr Leu Ala Gln
    930                 935                 940                 
Lys Pro Tyr Ala Gly Ile Leu Ser Glu Ser Met Lys Gln Val Ser Tyr
945                 950                 955                 960 
Leu Ala Ser Ile Val Arg Tyr Gly Glu Thr Pro Glu Thr Ser Phe Asn
                965                 970                 975     
Gln Trp Ala Trp Asn Leu Ile Leu Arg Leu Lys Leu His Lys Asn Asp
            980                 985                 990         
Tyr Gly Ile Gln Pro Asn Cys Pro Ala Val Pro Phe Ser Val Thr Val
        995                 1000                1005            
Pro Asp Met Thr Glu Ser Pro Thr Phe His Pro Leu Leu Lys Ala Val
    1010                1015                1020                
Lys Ala Gly Met Pro Ile Gly Cys Tyr Leu Ala Leu Ser Met Thr Ala
1025                1030                1035                1040
Val Gly His Ser Ile Glu Lys Phe Cys Ala Glu Gly Ile Pro Leu Leu
                1045                1050                1055    
Gly Ile Leu Val Gln Ser Arg His Leu Arg Thr Val Val His Val Leu
            1060                1065                1070        
Asp Lys Ile Leu Pro Leu Phe Tyr Pro Cys Gln Tyr Tyr Leu Leu Lys
        1075                1080                1085            
Asn Glu Gln Phe Leu Ser His Leu Leu Leu Phe Leu His Leu Asp Ser
    1090                1095                1100                
Gly Val Pro Gln Gly Val Thr Gln Gln Val Thr His Lys Val Ala Gln
1105                1110                1115                1120
His Leu Thr Gly Ala Ser His Gly Asp Asn Val Lys Leu Leu Asn Ser
                1125                1130                1135    
Met Ile Gln Ala His Ile Ser Val Ser Thr Gln Pro Asn Glu Val Gly
            1140                1145                1150        
Pro Val Ala Val Leu Glu Phe Trp Val Gln Ala Leu Ile Ser Gln His
        1155                1160                1165            
Leu Trp Tyr Arg Glu Gln Pro Ile Leu Phe Leu Met Asp His Leu Cys
    1170                1175                1180                
Lys Ala Ala Phe Gln Leu Met Gln Glu Asp Cys Ile Gln Lys Leu Leu
1185                1190                1195                1200
Tyr Gln Gln His Lys Asn Ala Leu Gly Tyr His Cys Asp Arg Ser Leu
                1205                1210                1215    
Leu Ser Ser Leu Val Ser Trp Ile Val Ala Gly Asn Ile Thr Pro Ser
            1220                1225                1230        
Phe Val Glu Gly Leu Ala Thr Pro Thr Gln Val Trp Phe Ala Trp Thr
        1235                1240                1245            
Val Leu Asn Met Glu Ser Ile Phe Glu Glu Asp Ser Gln Leu Arg Arg
    1250                1255                1260                
Val Ile Glu Gly Glu Leu Val Ile Asn Ser Ala Phe Thr Pro Asp Gln
1265                1270                1275                1280
Ala Leu Lys Lys Ala Gln Thr Gln Leu Lys Leu Pro Ile Val Pro Ser
                1285                1290                1295    
Leu Gln Arg Leu Leu Ile Tyr Arg Trp Ala His Gln Ala Leu Val Thr
            1300                1305                1310        
Pro Ser Asp His Pro Leu Leu Pro Leu Ile Trp Gln Lys Phe Phe Leu
        1315                1320                1325            
Leu Tyr Leu His Arg Pro Gly Pro Gln Tyr Gly Leu Pro Ile Asp Gly
    1330                1335                1340                
Cys Ile Gly Arg Arg Phe Phe Gln Ser Pro Ala His Ile Asn Leu Leu
1345                1350                1355                1360
Lys Glu Met Lys Arg Arg Leu Thr Glu Val Ala Asp Phe His His Ala
                1365                1370                1375    
Ala Ser Lys Ala Leu Arg Val Pro Ala Glu Gly Ser Glu Gly Leu Pro
            1380                1385                1390        
Glu Ser His Ser Gly Thr Pro Gly Tyr Leu Thr Ser Pro Glu Leu His
        1395                1400                1405            
Lys Glu Leu Val Arg Leu Phe Asn Val Tyr Ile Leu Trp Leu Glu Asp
    1410                1415                1420                
Glu Asn Phe Gln Lys Gly Asp Thr Tyr Ile Pro Ser Leu Pro Lys His
1425                1430                1435                1440
Tyr Asp Ile His Arg Leu Ala Lys Val Met Gln Asn Gln Gln Val Lys
                1445                1450                1455    
Leu
    


<210> 1011
<211> 1457
<212> PRT
<213> Homo sapiens

<400> 1011
Lys Thr Asn Gly Asp Gly Ala Ala Glu Gly Ser Met Ala Glu Ala Val
 1               5                  10                  15      
Lys Pro Gln Arg Arg Ala Lys Ala Lys Ala Ser Arg Thr Lys Thr Lys
            20                  25                  30          
Glu Lys Lys Lys Tyr Glu Thr Pro Gln Arg Glu Glu Ser Ser Glu Val
        35                  40                  45              
Ser Leu Pro Lys Thr Ser Arg Glu Gln Glu Ile Pro Ser Leu Ala Cys
    50                  55                  60                  
Glu Phe Lys Gly Asp His Leu Lys Val Val Thr Asp Ser Gln Leu Gln
65                  70                  75                  80  
Asp Asp Ala Ser Gly Gln Asn Glu Ser Glu Met Phe Asp Val Pro Leu
                85                  90                  95      
Thr Ser Leu Thr Ile Ser Asn Glu Glu Ser Leu Thr Cys Asn Thr Glu
            100                 105                 110         
Pro Pro Lys Glu Gly Gly Glu Ala Arg Pro Cys Val Gly Asp Ser Ala
        115                 120                 125             
Val Thr Pro Lys Val His Pro Gly Asp Asn Val Gly Thr Lys Val Glu
    130                 135                 140                 
Thr Pro Lys Asn Phe Thr Glu Val Glu Glu Asn Met Ser Val Gln Gly
145                 150                 155                 160 
Gly Leu Ser Glu Ser Ala Pro Gln Ser Asn Phe Ser Tyr Thr Gln Pro
                165                 170                 175     
Ala Met Glu Asn Ile Gln Val Arg Glu Thr Gln Asn Ser Lys Glu Asp
            180                 185                 190         
Glu Gln Gly Leu Val Cys Ser Ser Glu Val Pro Gln Asn Val Gly Leu
        195                 200                 205             
Gln Ser Ser Cys Pro Ala Lys His Gly Phe Gln Thr Pro Arg Val Lys
    210                 215                 220                 
Lys Leu Tyr Pro Gln Leu Pro Ala Glu Ile Ala Gly Glu Ala Pro Ala
225                 230                 235                 240 
Leu Val Ala Val Lys Pro Leu Leu Arg Ser Glu Arg Leu Tyr Pro Glu
                245                 250                 255     
Leu Pro Ser Gln Leu Glu Leu Val Pro Phe Thr Lys Glu Gln Leu Lys
            260                 265                 270         
Ile Leu Glu Pro Gly Ser Trp Leu Glu Asn Val Glu Ser Tyr Leu Glu
        275                 280                 285             
Glu Phe Asp Ser Met Ala His Gln Asp Arg His Glu Phe Tyr Glu Leu
    290                 295                 300                 
Leu Leu Asn Tyr Ser Arg Cys Arg Lys Gln Leu Leu Leu Ala Glu Ala
305                 310                 315                 320 
Glu Leu Leu Thr Leu Thr Ser Asp Cys Gln Asn Ala Lys Ser Arg Leu
                325                 330                 335     
Trp Gln Phe Lys Glu Glu Gln Met Ser Val Gln Gly Ile Cys Ala Asp
            340                 345                 350         
Gln Val Lys Val Phe Ser Tyr His Arg Tyr Gln Arg Val Glu Met Asn
        355                 360                 365             
Glu Asn Ala Leu Val Glu Leu Lys Lys Leu Phe Asp Ala Lys Ser Glu
    370                 375                 380                 
His Leu His Gln Thr Leu Ala Leu His Ser Tyr Thr Ser Val Leu Ser
385                 390                 395                 400 
Arg Leu Gln Val Glu Ser Tyr Ile Tyr Ala Leu Leu Ser Ser Ser Ala
                405                 410                 415     
Val Leu Arg Ser Ser Ala Ile His Gln Gln Gly Arg Ala Ser Lys Gln
            420                 425                 430         
Thr Glu Ser Ile Pro Ser Asp Leu Cys Gln Leu Lys Glu Cys Ile Ser
        435                 440                 445             
Val Leu Phe Met Phe Thr Arg Arg Val Asn Glu Asp Thr Gln Phe His
    450                 455                 460                 
Asp Asp Ile Leu Leu Trp Leu Gln Lys Leu Val Ser Val Leu Gln Arg
465                 470                 475                 480 
Val Gly Cys Pro Gly Asp His Leu Phe Leu Leu Asn His Ile Leu Arg
                485                 490                 495     
Cys Pro Ala Gly Val Ser Lys Trp Ala Val Pro Phe Ile Gln Ile Lys
            500                 505                 510         
Val Leu His Asn Pro Ser Gly Val Phe His Phe Met Gln Ser Leu Ala
        515                 520                 525             
Leu Leu Met Ser Pro Val Lys Asn Arg Ala Glu Phe Met Cys His Met
    530                 535                 540                 
Lys Pro Ser Glu Arg Lys Pro Ser Ser Ser Gly Pro Gly Ser Gly Thr
545                 550                 555                 560 
Trp Thr Leu Val Asp Glu Gly Gly Glu Glu Asp Glu Asp Pro Glu Thr
                565                 570                 575     
Ser Trp Ile Leu Leu Asn Glu Asp Asp Leu Val Thr Ile Leu Ala Gln
            580                 585                 590         
Phe Pro Phe His Glu Leu Phe Gln His Leu Leu Gly Phe Lys Ala Lys
        595                 600                 605             
Gly Asp Tyr Leu Pro Glu Thr Thr Arg Pro Gln Glu Met Met Lys Ile
    610                 615                 620                 
Phe Ala Phe Ala Asn Ser Leu Val Glu Leu Leu Ala Val Gly Leu Glu
625                 630                 635                 640 
Thr Phe Asn Arg Ala Arg Tyr Arg Gln Phe Val Lys Arg Ile Gly Tyr
                645                 650                 655     
Met Ile Arg Met Thr Leu Gly Tyr Val Ser Asp His Trp Ala Gln Tyr
            660                 665                 670         
Val Ser His Asn Gln Gly Ser Gly Leu Ala Gln Gln Pro Tyr Ser Met
        675                 680                 685             
Glu Lys Leu Gln Val Glu Phe Asp Glu Leu Phe Leu Arg Ala Val Leu
    690                 695                 700                 
His Val Leu Lys Ala Lys Arg Leu Gly Ile Trp Leu Phe Met Ser Glu
705                 710                 715                 720 
Met Pro Phe Gly Thr Leu Ser Val Gln Met Leu Trp Lys Leu Phe Tyr
                725                 730                 735     
Leu Met His Gln Val Glu Ser Glu Asn Leu Gln Gln Leu Ser Ser Ser
            740                 745                 750         
Leu Gln Pro Ala Gln Cys Lys Gln Gln Leu Gln Asp Pro Glu His Phe
        755                 760                 765             
Thr Asn Phe Glu Lys Cys Leu Ser Ser Met Asn Ser Ser Glu Glu Ile
    770                 775                 780                 
Cys Leu Leu Thr Thr Phe Ala Gln Met Ala Gln Ala Arg Arg Thr Asn
785                 790                 795                 800 
Val Asp Glu Asp Phe Ile Lys Ile Ile Val Leu Glu Ile Tyr Glu Val
                805                 810                 815     
Ser Tyr Val Thr Leu Ser Thr Arg Glu Thr Phe Ser Lys Val Gly Arg
            820                 825                 830         
Glu Leu Leu Gly Thr Ile Thr Ala Val His Pro Glu Ile Ile Ser Val
        835                 840                 845             
Leu Leu Asp Arg Val Gln Glu Thr Ile Asp Gln Val Gly Met Val Ser
    850                 855                 860                 
Leu Tyr Leu Phe Lys Glu Leu Pro Leu Tyr Leu Trp Gln Pro Ser Ala
865                 870                 875                 880 
Ser Glu Ile Ala Val Ile Arg Asp Trp Leu Leu Asn Tyr Asn Leu Thr
                885                 890                 895     
Val Val Lys Asn Lys Leu Ala Cys Val Ile Leu Glu Gly Leu Asn Trp
            900                 905                 910         
Gly Phe Ala Lys Gln Ala Thr Leu His Leu Asp Gln Ala Val His Ala
        915                 920                 925             
Glu Val Ala Leu Met Val Leu Glu Ala Tyr Gln Lys Tyr Leu Ala Gln
    930                 935                 940                 
Lys Pro Tyr Ala Gly Ile Leu Ser Glu Ser Met Lys Gln Val Ser Tyr
945                 950                 955                 960 
Leu Ala Ser Ile Val Arg Tyr Gly Glu Thr Pro Glu Thr Ser Phe Asn
                965                 970                 975     
Gln Trp Ala Trp Asn Leu Ile Leu Arg Leu Lys Leu His Lys Asn Asp
            980                 985                 990         
Tyr Gly Ile Gln Pro Asn Cys Pro Ala Val Pro Phe Ser Val Thr Val
        995                 1000                1005            
Pro Asp Met Thr Glu Ser Pro Thr Phe His Pro Leu Leu Lys Ala Val
    1010                1015                1020                
Lys Ala Gly Met Pro Ile Gly Cys Tyr Leu Ala Leu Ser Met Thr Ala
1025                1030                1035                1040
Val Gly His Ser Ile Glu Lys Phe Cys Ala Glu Gly Ile Pro Leu Leu
                1045                1050                1055    
Gly Ile Leu Val Gln Ser Arg His Leu Arg Thr Val Val His Val Leu
            1060                1065                1070        
Asp Lys Ile Leu Pro Leu Phe Tyr Pro Cys Gln Tyr Tyr Leu Leu Lys
        1075                1080                1085            
Asn Glu Gln Phe Leu Ser His Leu Leu Leu Phe Leu His Leu Asp Ser
    1090                1095                1100                
Gly Val Pro Gln Gly Val Thr Gln Gln Val Thr His Lys Val Ala Gln
1105                1110                1115                1120
His Leu Thr Gly Ala Ser His Gly Asp Asn Val Lys Leu Leu Asn Ser
                1125                1130                1135    
Met Ile Gln Ala His Ile Ser Val Ser Thr Gln Pro Asn Glu Val Gly
            1140                1145                1150        
Pro Val Ala Val Leu Glu Phe Trp Val Gln Ala Leu Ile Ser Gln His
        1155                1160                1165            
Leu Trp Tyr Arg Glu Gln Pro Ile Leu Phe Leu Met Asp His Leu Cys
    1170                1175                1180                
Lys Ala Ala Phe Gln Leu Met Gln Glu Asp Cys Ile Gln Lys Leu Leu
1185                1190                1195                1200
Tyr Gln Gln His Lys Asn Ala Leu Gly Tyr His Cys Asp Arg Ser Leu
                1205                1210                1215    
Leu Ser Ser Leu Val Ser Trp Ile Val Ala Gly Asn Ile Thr Pro Ser
            1220                1225                1230        
Phe Val Glu Gly Leu Ala Thr Pro Thr Gln Val Trp Phe Ala Trp Thr
        1235                1240                1245            
Val Leu Asn Met Glu Ser Ile Phe Glu Glu Asp Ser Gln Leu Arg Arg
    1250                1255                1260                
Val Ile Glu Gly Glu Leu Val Ile Asn Ser Ala Phe Thr Pro Asp Gln
1265                1270                1275                1280
Ala Leu Lys Lys Ala Gln Thr Gln Leu Lys Leu Pro Ile Val Pro Ser
                1285                1290                1295    
Leu Gln Arg Leu Leu Ile Tyr Arg Trp Ala His Gln Ala Leu Val Thr
            1300                1305                1310        
Pro Ser Asp His Pro Leu Leu Pro Leu Ile Trp Gln Lys Phe Phe Leu
        1315                1320                1325            
Leu Tyr Leu His Arg Pro Gly Pro Gln Tyr Gly Leu Pro Ile Asp Gly
    1330                1335                1340                
Cys Ile Gly Arg Arg Phe Phe Gln Ser Pro Ala His Ile Asn Leu Leu
1345                1350                1355                1360
Lys Glu Met Lys Arg Arg Leu Thr Glu Val Ala Asp Phe His His Ala
                1365                1370                1375    
Ala Ser Lys Ala Leu Arg Val Pro Ala Glu Gly Ser Glu Gly Leu Pro
            1380                1385                1390        
Glu Ser His Ser Gly Thr Pro Gly Tyr Leu Thr Ser Pro Glu Leu His
        1395                1400                1405            
Lys Glu Leu Val Arg Leu Phe Asn Val Tyr Ile Leu Trp Leu Glu Asp
    1410                1415                1420                
Glu Asn Phe Gln Lys Gly Asp Thr Tyr Ile Pro Ser Leu Pro Lys His
1425                1430                1435                1440
Tyr Asp Ile His Arg Leu Ala Lys Val Met Gln Asn Gln Gln Val Lys
                1445                1450                1455    
Leu
    


<210> 1012
<211> 1435
<212> PRT
<213> Homo sapiens

<400> 1012
Phe Pro Ile Pro Leu Asp Glu Ser Ser Ser His Glu Cys Asn Gln Arg
 1               5                  10                  15      
Thr Ile Leu Leu Tyr Gly Val Gly Lys Glu Arg Asp Glu Ala Arg His
            20                  25                  30          
Gln Leu Lys Lys Ile Thr Lys Asp Ile Leu Lys Ile Leu Asn Lys Lys
        35                  40                  45              
Ser Thr Thr Glu Thr Gly Val Gly Asp Glu Gly Gln Lys Ala Arg Lys
    50                  55                  60                  
Asn Lys Gln Glu Thr Phe Pro Thr Leu Glu Thr Val Phe Thr Lys Leu
65                  70                  75                  80  
Gln Leu Leu Ser Tyr Phe Asp Gln His Gln Val Thr Ser Gln Ile Ser
                85                  90                  95      
Asn Asn Val Leu Glu Gln Ile Thr Ser Phe Ala Ser Gly Thr Ser Tyr
            100                 105                 110         
His Leu Pro Leu Ala His His Ile Gln Leu Ile Phe Asp Leu Met Glu
        115                 120                 125             
Pro Ala Leu Asn Ile Asn Gly Leu Ile Asp Phe Ala Ile Gln Leu Leu
    130                 135                 140                 
Asn Glu Leu Ser Val Val Glu Ala Glu Leu Leu Leu Lys Ser Ser Ser
145                 150                 155                 160 
Leu Ala Gly Ser Tyr Thr Thr Gly Leu Cys Val Cys Ile Val Ala Val
                165                 170                 175     
Leu Arg Arg Tyr His Ser Cys Leu Ile Leu Asn Pro Asp Gln Thr Ala
            180                 185                 190         
Gln Val Phe Glu Gly Leu Cys Gly Val Val Lys His Val Val Asn Pro
        195                 200                 205             
Ser Glu Cys Ser Ser Pro Glu Arg Cys Ile Leu Ala Tyr Leu Tyr Asp
    210                 215                 220                 
Leu Tyr Val Ser Cys Ser His Leu Arg Ser Lys Phe Gly Asp Leu Phe
225                 230                 235                 240 
Ser Ser Ala Cys Ser Lys Val Lys Gln Thr Ile Tyr Asn Asn Val Met
                245                 250                 255     
Pro Ala Asn Ser Asn Leu Arg Trp Asp Pro Asp Phe Met Met Asp Phe
            260                 265                 270         
Ile Glu Asn Pro Ser Ala Arg Ser Ile Asn Tyr Ser Met Leu Gly Lys
        275                 280                 285             
Ile Leu Ser Asp Asn Ala Ala Asn Arg Tyr Ser Phe Val Cys Asn Thr
    290                 295                 300                 
Leu Met Asn Val Cys Met Gly His Gln Asp Ala Gly Arg Ile Asn Asp
305                 310                 315                 320 
Ile Ala Asn Phe Ser Ser Glu Leu Thr Ala Cys Cys Thr Val Leu Ser
                325                 330                 335     
Ser Glu Trp Leu Gly Val Leu Lys Ala Leu Cys Cys Ser Ser Asn His
            340                 345                 350         
Val Trp Gly Phe Asn Asp Val Leu Cys Thr Val Asp Val Ser Asp Leu
        355                 360                 365             
Ser Phe His Asp Ser Leu Ala Thr Phe Ile Ala Ile Leu Ile Ala Arg
    370                 375                 380                 
Gln Cys Phe Ser Leu Glu Asp Val Val Gln His Val Ala Leu Pro Ser
385                 390                 395                 400 
Leu Leu Ala Ala Ala Cys Gly Asp Ala Asp Ala Glu Pro Gly Ala Arg
                405                 410                 415     
Met Thr Cys Arg Leu Leu Leu His Leu Phe Arg Ala Pro Gln Ala Cys
            420                 425                 430         
Phe Leu Pro Gln Ala Thr Gly Lys Pro Phe Pro Gly Ile Arg Ser Ser
        435                 440                 445             
Cys Asp Arg His Leu Leu Ala Ala Ala His Asn Ser Ile Glu Val Gly
    450                 455                 460                 
Ala Val Phe Ala Val Leu Lys Ala Ile Met Met Leu Gly Asp Ala Lys
465                 470                 475                 480 
Ile Gly Asn Asn Ser Val Ser Ser Leu Lys Asn Asp Asp Phe Thr Met
                485                 490                 495     
Arg Gly Leu Arg Cys Asp Gly Asn Ala Asp Asp Ile Trp Thr Ala Ser
            500                 505                 510         
Gln Asn Pro Lys Ser Cys Gly Lys Ser Ile Ser Ile Glu Thr Ala Asn
        515                 520                 525             
Leu Arg Glu Tyr Ala Arg Tyr Val Leu Arg Thr Ile Cys Gln Gln Glu
    530                 535                 540                 
Trp Val Gly Glu His Cys Leu Lys Glu Pro Glu Arg Leu Cys Thr Asp
545                 550                 555                 560 
Lys Glu Leu Ile Leu Asp Pro Val Leu Ser Asn Met Gln Ala Gln Lys
                565                 570                 575     
Leu Leu Gln Leu Ile Cys Tyr Pro His Gly Ile Lys Glu Cys Thr Glu
            580                 585                 590         
Gly Asp Asn Leu Gln Arg Gln His Ile Lys Arg Ile Leu Gln Asn Leu
        595                 600                 605             
Glu Gln Trp Thr Leu Arg Gln Ser Trp Leu Glu Leu Gln Leu Met Ile
    610                 615                 620                 
Lys Gln Cys Leu Lys Asp Pro Gly Ser Gly Ser Val Ala Glu Met Asn
625                 630                 635                 640 
Asn Leu Leu Asp Asn Ile Ala Lys Ala Thr Ile Glu Val Phe Gln Gln
                645                 650                 655     
Ser Ala Asp Leu Asn Asn Ser Ser Asn Ser Gly Met Ser Leu Phe Asn
            660                 665                 670         
Pro Asn Ser Ile Gly Ser Ala Asp Thr Ser Ser Thr Arg Gln Asn Gly
        675                 680                 685             
Ile Lys Thr Phe Leu Ser Ser Ser Glu Arg Arg Gly Val Trp Leu Val
    690                 695                 700                 
Ala Pro Leu Ile Ala Arg Leu Pro Thr Ser Val Gln Gly Arg Val Leu
705                 710                 715                 720 
Lys Ala Ala Gly Glu Glu Leu Glu Lys Gly Gln His Leu Gly Ser Ser
                725                 730                 735     
Ser Lys Lys Glu Arg Asp Arg Gln Lys Gln Lys Ser Met Ser Leu Leu
            740                 745                 750         
Ser Gln Gln Pro Phe Leu Ser Leu Val Leu Thr Cys Leu Lys Gly Gln
        755                 760                 765             
Asp Glu Gln Arg Glu Gly Leu Leu Thr Ser Leu Gln Asn Gln Val Asn
    770                 775                 780                 
Gln Ile Leu Ser Asn Trp Arg Glu Glu Arg Tyr Gln Asp Asp Ile Lys
785                 790                 795                 800 
Ala Arg Gln Met Met His Glu Ala Leu Gln Leu Arg Leu Asn Leu Val
                805                 810                 815     
Gly Gly Met Phe Asp Thr Val Gln Arg Ser Thr Gln Trp Thr Thr Asp
            820                 825                 830         
Trp Ala Leu Leu Leu Leu Gln Ile Ile Thr Ser Gly Thr Val Asp Met
        835                 840                 845             
His Thr Asn Asn Glu Leu Phe Thr Thr Val Leu Asp Met Leu Gly Val
    850                 855                 860                 
Leu Ile Asn Gly Thr Leu Ala Ser Asp Leu Ser Asn Ala Ser Pro Gly
865                 870                 875                 880 
Gly Ser Glu Glu Asn Lys Arg Ala Tyr Met Asn Leu Val Lys Lys Leu
                885                 890                 895     
Lys Lys Glu Leu Gly Asp Lys Arg Ser Glu Ser Ile Asp Lys Val Arg
            900                 905                 910         
Gln Leu Leu Pro Leu Pro Lys Gln Thr Cys Asp Val Ile Thr Cys Glu
        915                 920                 925             
Pro Met Gly Ser Leu Ile Asp Thr Lys Gly Asn Lys Ile Ala Gly Phe
    930                 935                 940                 
Asp Ser Ile Asp Lys Lys Gln Gly Leu Gln Val Ser Thr Lys Gln Lys
945                 950                 955                 960 
Val Ser Pro Trp Asp Leu Phe Glu Gly Gln Lys Asn Pro Ala Pro Leu
                965                 970                 975     
Ser Trp Ala Trp Phe Gly Thr Val Arg Val Asp Arg Arg Val Ile Lys
            980                 985                 990         
Tyr Glu Glu Gln His His Leu Leu Leu Tyr His Thr His Pro Met Pro
        995                 1000                1005            
Lys Pro Arg Ser Tyr Tyr Leu Gln Pro Leu Pro Leu Pro Pro Glu Glu
    1010                1015                1020                
Glu Glu Glu Glu Pro Thr Ser Pro Val Ser Gln Glu Pro Glu Arg Lys
1025                1030                1035                1040
Ser Ala Glu Leu Ser Asp Gln Gly Lys Thr Thr Thr Asp Glu Glu Lys
                1045                1050                1055    
Lys Thr Lys Gly Arg Lys Arg Lys Thr Lys Ser Ser Ser Arg Val Asp
            1060                1065                1070        
Glu Tyr Pro Gln Ser Asn Ile Tyr Arg Val Pro Pro Asn Tyr Ser Pro
        1075                1080                1085            
Ile Ser Ser Gln Met Met His His Pro Gln Ser Thr Leu Trp Gly Tyr
    1090                1095                1100                
Asn Leu Val Gly Gln Pro Gln Gln Pro Gly Phe Phe Leu Gln Asn Gln
1105                1110                1115                1120
Ser Leu Thr Pro Gly Gly Ser Arg Leu Asp Pro Ala Gly Ser Phe Val
                1125                1130                1135    
Pro Thr Asn Thr Lys Gln Ala Leu Ser Asn Met Leu Gln Arg Arg Ser
            1140                1145                1150        
Gly Ala Met Met Gln Pro Pro Ser Leu His Ala Ile Thr Ser Gln Gln
        1155                1160                1165            
Gln Leu Ile Gln Met Lys Leu Leu Gln Gln Gln Gln Gln Gln Arg Leu
    1170                1175                1180                
Leu Arg Gln Ala Gln Thr Arg Pro Phe Gln Gln Gly Gln Pro Gly Asp
1185                1190                1195                1200
Gln Ala Ala Leu Phe Ala Ala Gln Ala Arg Pro Ser Pro Gln Leu Pro
                1205                1210                1215    
Gln Tyr Pro Gly Leu Gln Gln Ala Gln Thr Met Pro Gln Gly Tyr Thr
            1220                1225                1230        
Met Tyr Gly Thr Gln Met Pro Leu Gln Gln Thr Ser Gln Gln Gln Ala
        1235                1240                1245            
Gly Ser Val Val Leu Ser Pro Ser Tyr Asn Ser Arg Ala Tyr Pro Ala
    1250                1255                1260                
Ala His Ser Asn Pro Val Leu Met Glu Arg Leu Arg Gln Ile Gln Gln
1265                1270                1275                1280
Gln Pro Ser Gly Tyr Val Gln Gln Gln Ala Ser Pro Tyr Leu Gln Pro
                1285                1290                1295    
Leu Thr Gly Ser Gln Arg Leu Asn His Gln Ala Leu Gln Gln Ser Pro
            1300                1305                1310        
Leu Val Gly Gly Gly Ile Asp Ala Val Leu Thr Ser Ala His Pro Asn
        1315                1320                1325            
Leu Pro Ser Val Pro Leu Pro Gln Asp Pro Met Arg Pro Arg Gln Pro
    1330                1335                1340                
Gln Val Arg Gln Gln Gln Arg Leu Leu Gln Met Gln Gln Pro Gln Gln
1345                1350                1355                1360
Pro Gln Pro Gln Gln Pro Pro Gln Pro Gln Gln Ser Ser Gln Ser Gln
                1365                1370                1375    
Ser Gln Thr Leu Gly Leu Gln Ala Met Gln Pro Gln Gln Pro Leu Phe
            1380                1385                1390        
Pro Arg Gln Gly Leu Gln Gln Thr Gln Gln Gln Gln Gln Thr Ala Ala
        1395                1400                1405            
Leu Val Arg Gln Leu Gln Lys Gln Leu Ser Ser Asn Gln Pro Gln Gln
    1410                1415                1420                
Gly Val Thr Pro Tyr Gly His Pro Ser His Phe
1425                1430                1435


<210> 1013
<211> 1997
<212> PRT
<213> Homo sapiens

<400> 1013
Arg Leu Phe Val Pro Arg Glu Gly Cys Gly Ile Trp Asp Ile Asp Lys
 1               5                  10                  15      
Ala Trp Gly Glu Leu Glu Lys Ala Glu His Glu Arg Glu Ala Ala Leu
            20                  25                  30          
Arg Ala Glu Leu Ile Arg Gln Glu Lys Leu Glu Leu Leu Ala Gln Arg
        35                  40                  45              
Phe Asp His Lys Val Ala Met Arg Glu Ser Trp Leu Asn Glu Asn Gln
    50                  55                  60                  
Arg Leu Val Ser Gln Asp Asn Phe Gly Tyr Glu Leu Pro Ala Val Glu
65                  70                  75                  80  
Ala Ala Met Lys Lys His Glu Ala Ile Glu Ala Asp Ile Ala Ala Tyr
                85                  90                  95      
Glu Glu Arg Val Gln Gly Val Ala Glu Leu Ala Gln Ala Leu Ala Ala
            100                 105                 110         
Glu Gly Tyr Tyr Asp Ile Arg Arg Val Ala Ala Gln Arg Asp Ser Val
        115                 120                 125             
Leu Arg Gln Trp Ala Leu Leu Thr Gly Leu Val Gly Ala Arg Arg Thr
    130                 135                 140                 
Arg Leu Glu Gln Asn Leu Ala Leu Gln Lys Val Phe Gln Glu Met Val
145                 150                 155                 160 
Tyr Met Val Asp Trp Met Glu Glu Met Gln Ala Gln Leu Leu Ser Arg
                165                 170                 175     
Glu Cys Gly Gln His Leu Val Glu Ala Asp Asp Leu Leu Gln Lys His
            180                 185                 190         
Gly Leu Leu Glu Gly Asp Ile Ala Ala Gln Ser Glu Arg Val Glu Ala
        195                 200                 205             
Leu Asn Ala Ala Ala Leu Arg Phe Ser Gln Leu Gln Gly Tyr Gln Pro
    210                 215                 220                 
Cys Asp Pro Gln Val Ile Cys Asn Arg Val Asn His Val His Gly Cys
225                 230                 235                 240 
Leu Ala Glu Leu Gln Glu Gln Ala Ala Arg Arg Arg Ala Glu Leu Glu
                245                 250                 255     
Ala Ser Arg Ser Leu Trp Ala Leu Leu Gln Glu Leu Glu Glu Ala Glu
            260                 265                 270         
Ser Trp Ala Arg Asp Lys Glu Arg Leu Leu Glu Ala Ala Gly Gly Gly
        275                 280                 285             
Gly Ala Ala Gly Ala Ala Gly Ala Ala Gly Thr Ala Gly Gly Ala His
    290                 295                 300                 
Asp Leu Ser Ser Thr Ala Arg Leu Leu Ala Gln His Lys Ile Leu Gln
305                 310                 315                 320 
Gly Glu Leu Gly Gly Arg Arg Ala Leu Leu Gln Gln Ala Leu Arg Cys
                325                 330                 335     
Gly Glu Glu Leu Val Ala Ala Gly Gly Ala Val Gly Pro Gly Ala Asp
            340                 345                 350         
Thr Val His Leu Val Gly Leu Ala Glu Arg Ala Ala Ser Ala Arg Arg
        355                 360                 365             
Arg Trp Gln Arg Leu Glu Glu Ala Ala Ala Arg Arg Glu Arg Arg Leu
    370                 375                 380                 
Gln Glu Ala Arg Ala Leu His Gln Phe Gly Ala Asp Leu Asp Gly Leu
385                 390                 395                 400 
Leu Asp Trp Leu Arg Asp Ala Tyr Arg Leu Ala Ala Ala Gly Asp Phe
                405                 410                 415     
Gly His Asp Glu Ala Ser Ser Arg Arg Leu Ala Arg Gln His Arg Ala
            420                 425                 430         
Leu Thr Gly Glu Val Glu Ala His Arg Gly Pro Val Ser Gly Leu Arg
        435                 440                 445             
Arg Gln Leu Ala Thr Leu Gly Gly Ala Ser Gly Ala Gly Pro Leu Val
    450                 455                 460                 
Val Ala Leu Gln Val Arg Val Val Glu Ala Glu Gln Leu Phe Ala Glu
465                 470                 475                 480 
Val Thr Glu Val Ala Ala Leu Arg Arg Gln Trp Leu Arg Asp Ala Leu
                485                 490                 495     
Ala Val Tyr Arg Met Phe Gly Glu Val His Ala Cys Glu Leu Trp Ile
            500                 505                 510         
Gly Glu Lys Glu Gln Trp Leu Leu Ser Met Arg Val Pro Asp Ser Leu
        515                 520                 525             
Asp Asp Val Glu Val Val Gln His Arg Phe Glu Ser Leu Asp Gln Glu
    530                 535                 540                 
Met Asn Ser Leu Met Gly Arg Val Leu Asp Val Asn His Thr Val Gln
545                 550                 555                 560 
Glu Leu Val Glu Gly Gly His Pro Ser Ser Asp Glu Val Arg Ser Cys
                565                 570                 575     
Gln Asp His Leu Asn Ser Arg Trp Asn Arg Ile Val Glu Leu Val Glu
            580                 585                 590         
Gln Arg Lys Glu Glu Met Ser Ala Val Leu Leu Val Glu Asn His Val
        595                 600                 605             
Leu Glu Val Ala Glu Val Arg Ala Gln Val Arg Glu Lys Arg Arg Ala
    610                 615                 620                 
Val Glu Ser Ala Pro Arg Ala Gly Gly Ala Leu Gln Trp Arg Leu Ser
625                 630                 635                 640 
Gly Leu Glu Ala Ala Leu Gln Ala Leu Glu Pro Arg Gln Ala Ala Leu
                645                 650                 655     
Leu Glu Glu Ala Ala Leu Leu Ala Glu Arg Phe Pro Ala Gln Ala Ala
            660                 665                 670         
Arg Leu His Gln Gly Ala Glu Glu Leu Gly Ala Glu Trp Gly Ala Leu
        675                 680                 685             
Ala Ser Ala Ala Gln Ala Cys Gly Glu Ala Val Ala Ala Ala Gly Arg
    690                 695                 700                 
Leu Gln Arg Phe Leu His Asp Leu Asp Ala Phe Leu Asp Trp Leu Val
705                 710                 715                 720 
Arg Ala Gln Glu Ala Ala Gly Gly Ser Glu Gly Pro Leu Pro Asn Ser
                725                 730                 735     
Leu Glu Glu Ala Asp Ala Leu Leu Ala Arg His Ala Ala Leu Lys Glu
            740                 745                 750         
Glu Val Asp Gln Arg Glu Glu Asp Tyr Ala Arg Ile Val Ala Ala Ser
        755                 760                 765             
Glu Ala Leu Leu Ala Ala Asp Gly Ala Glu Leu Gly Pro Gly Leu Ala
    770                 775                 780                 
Leu Asp Glu Trp Leu Pro His Leu Glu Leu Gly Trp His Lys Leu Leu
785                 790                 795                 800 
Gly Leu Trp Glu Ala Arg Arg Glu Ala Leu Val Gln Ala His Ile Tyr
                805                 810                 815     
Gln Leu Phe Leu Arg Asp Leu Arg Gln Ala Leu Val Val Leu Arg Asn
            820                 825                 830         
Gln Glu Met Ala Leu Ser Gly Ala Glu Leu Pro Gly Thr Val Glu Ser
        835                 840                 845             
Val Glu Glu Ala Leu Lys Gln His Arg Asp Phe Leu Thr Thr Met Glu
    850                 855                 860                 
Leu Ser Gln Gln Lys Met Gln Val Ala Val Gln Ala Ala Glu Gly Leu
865                 870                 875                 880 
Leu Arg Gln Gly Asn Ile Tyr Gly Glu Gln Ala Gln Glu Ala Val Thr
                885                 890                 895     
Arg Leu Leu Glu Lys Asn Gln Glu Asn Gln Leu Arg Ala Gln Gln Trp
            900                 905                 910         
Met Gln Lys Leu His Asp Gln Leu Glu Leu Gln His Phe Leu Arg Asp
        915                 920                 925             
Cys His Glu Leu Asp Gly Trp Ile His Glu Lys Met Leu Met Ala Arg
    930                 935                 940                 
Asp Gly Thr Arg Glu Asp Asn His Lys Leu His Lys Arg Trp Leu Arg
945                 950                 955                 960 
His Gln Ala Phe Met Ala Glu Leu Ala Gln Asn Lys Glu Trp Leu Glu
                965                 970                 975     
Lys Ile Glu Arg Glu Gly Gln Gln Leu Met Gln Glu Lys Pro Glu Leu
            980                 985                 990         
Ala Ala Ser Val Arg Lys Lys Leu Gly Glu Ile Arg Gln Cys Trp Ala
        995                 1000                1005            
Glu Leu Glu Ser Thr Thr Gln Ala Lys Ala Arg Gln Leu Phe Glu Ala
    1010                1015                1020                
Ser Lys Ala Asp Gln Leu Val Gln Ser Phe Ala Glu Leu Asp Lys Lys
1025                1030                1035                1040
Leu Leu His Met Glu Ser Gln Leu Gln Asp Val Asp Pro Gly Gly Asp
                1045                1050                1055    
Leu Ala Thr Val Asn Ser Gln Leu Lys Lys Leu Gln Ser Met Glu Ser
            1060                1065                1070        
Gln Val Glu Glu Trp Tyr Arg Glu Val Gly Glu Leu Gln Ala Gln Thr
        1075                1080                1085            
Ala Ala Leu Pro Leu Glu Pro Ala Ser Lys Glu Leu Val Gly Glu Arg
    1090                1095                1100                
Gln Asn Ala Val Gly Glu Arg Leu Val Arg Leu Leu Glu Pro Leu Gln
1105                1110                1115                1120
Glu Arg Arg Arg Leu Leu Leu Ala Ser Lys Glu Leu His Gln Val Ala
                1125                1130                1135    
His Asp Leu Asp Asp Glu Leu Ala Trp Val Gln Glu Arg Leu Pro Leu
            1140                1145                1150        
Ala Met Gln Thr Glu Arg Gly Asn Gly Leu Gln Ala Val Gln Gln His
        1155                1160                1165            
Ile Lys Lys Asn Gln Gly Leu Arg Arg Glu Ile Gln Ala His Gly Pro
    1170                1175                1180                
Arg Leu Glu Glu Val Leu Glu Arg Ala Gly Ala Leu Ala Ser Leu Arg
1185                1190                1195                1200
Ser Pro Glu Ala Glu Ala Val Arg Arg Gly Leu Glu Gln Leu Gln Ser
                1205                1210                1215    
Ala Trp Ala Gly Leu Arg Glu Ala Ala Glu Arg Arg Gln Gln Val Leu
            1220                1225                1230        
Asp Ala Ala Phe Gln Val Glu Gln Tyr Tyr Phe Asp Val Ala Glu Val
        1235                1240                1245            
Glu Ala Trp Leu Gly Glu Gln Glu Leu Leu Met Met Ser Glu Asp Lys
    1250                1255                1260                
Gly Lys Asp Glu Gln Ser Thr Leu Gln Leu Leu Lys Lys His Leu Gln
1265                1270                1275                1280
Leu Glu Gln Gly Val Glu Asn Tyr Glu Glu Ser Ile Ala Gln Leu Ser
                1285                1290                1295    
Arg Gln Cys Arg Ala Leu Leu Glu Met Gly His Pro Asp Ser Glu Gln
            1300                1305                1310        
Ile Ser Arg Arg Gln Ser Gln Val Asp Arg Leu Tyr Val Ala Leu Lys
        1315                1320                1325            
Glu Leu Gly Glu Glu Arg Arg Val Ala Leu Glu Gln Gln Tyr Trp Leu
    1330                1335                1340                
Tyr Gln Leu Ser Arg Gln Val Ser Glu Leu Glu His Trp Ile Ala Glu
1345                1350                1355                1360
Lys Glu Val Val Ala Gly Ser Pro Glu Leu Gly Gln Asp Phe Glu His
                1365                1370                1375    
Val Ser Val Leu Gln Glu Lys Phe Ser Glu Phe Ala Ser Glu Thr Gly
            1380                1385                1390        
Met Ala Gly Arg Glu Arg Leu Ala Ala Val Asn Gln Met Val Asp Glu
        1395                1400                1405            
Leu Ile Glu Cys Gly His Thr Ala Ala Ala Thr Met Ala Glu Trp Lys
    1410                1415                1420                
Asp Gly Leu Asn Glu Ala Trp Ala Glu Leu Leu Glu Leu Met Gly Thr
1425                1430                1435                1440
Arg Ala Gln Leu Leu Ala Ala Ser Arg Glu Leu His Lys Phe Phe Ser
                1445                1450                1455    
Asp Ala Arg Glu Leu Gln Gly Gln Ile Glu Glu Lys Arg Arg Arg Leu
            1460                1465                1470        
Pro Arg Leu Thr Thr Pro Pro Glu Pro Arg Pro Ser Ala Ser Ser Met
        1475                1480                1485            
Gln Arg Thr Leu Arg Ala Phe Glu His Asp Leu Gln Leu Leu Val Ser
    1490                1495                1500                
Gln Val Arg Gln Leu Gln Glu Gly Ala Ala Gln Leu Arg Thr Val Tyr
1505                1510                1515                1520
Ala Gly Glu His Ala Glu Ala Ile Ala Ser Arg Glu Gln Glu Val Leu
                1525                1530                1535    
Gln Gly Trp Lys Glu Leu Leu Ser Ala Cys Glu Asp Ala Arg Leu His
            1540                1545                1550        
Val Ser Ser Thr Ala Asp Ala Leu Arg Phe His Ser Gln Val Arg Asp
        1555                1560                1565            
Leu Leu Ser Trp Met Asp Gly Ile Ala Ser Gln Ile Gly Ala Ala Asp
    1570                1575                1580                
Lys Pro Arg Asp Val Ser Ser Val Glu Val Leu Met Asn Tyr His Gln
1585                1590                1595                1600
Gly Leu Lys Thr Glu Leu Glu Ala Arg Val Pro Glu Leu Thr Thr Cys
                1605                1610                1615    
Gln Glu Leu Gly Arg Ser Leu Leu Leu Asn Lys Ser Ala Met Ala Asp
            1620                1625                1630        
Glu Ile Gln Ala Gln Leu Asp Lys Leu Gly Thr Arg Lys Glu Glu Val
        1635                1640                1645            
Ser Glu Lys Trp Asp Arg His Trp Glu Trp Leu Gln Gln Met Leu Glu
    1650                1655                1660                
Val His Gln Phe Ala Gln Glu Ala Val Val Ala Asp Ala Trp Leu Thr
1665                1670                1675                1680
Ala Gln Glu Pro Leu Leu Gln Ser Arg Glu Leu Gly Ser Ser Val Asp
                1685                1690                1695    
Glu Val Glu Gln Leu Ile Arg Arg His Glu Ala Phe Arg Lys Ala Ala
            1700                1705                1710        
Ala Ala Trp Glu Glu Arg Phe Ser Ser Leu Arg Arg Leu Thr Thr Ile
        1715                1720                1725            
Glu Lys Ile Lys Ala Glu Gln Ser Lys Gln Pro Pro Thr Pro Leu Leu
    1730                1735                1740                
Gly Arg Lys Phe Phe Gly Asp Pro Thr Glu Leu Ala Ala Lys Ala Ala
1745                1750                1755                1760
Pro Leu Leu Arg Pro Gly Gly Tyr Glu Arg Gly Leu Glu Pro Leu Ala
                1765                1770                1775    
Arg Arg Ala Ser Asp Thr Leu Ser Ala Glu Val Arg Thr Arg Val Gly
            1780                1785                1790        
Tyr Val Arg Gln Glu Leu Lys Pro Glu Arg Leu Gln Pro Arg Ile Asp
        1795                1800                1805            
Arg Leu Pro Glu Ile Pro Gly Arg Val Glu Pro Ala Ala Leu Pro Ala
    1810                1815                1820                
Ala Pro Glu Asp Ala Ala Glu Thr Pro Ala Thr Pro Ala Ala Ala Glu
1825                1830                1835                1840
Gln Val Arg Pro Arg Pro Glu Arg Gln Glu Ser Ala Asp Arg Ala Glu
                1845                1850                1855    
Glu Leu Pro Arg Arg Arg Arg Pro Glu Arg Gln Glu Ser Val Asp Gln
            1860                1865                1870        
Ser Glu Glu Ala Ala Arg Arg Arg Arg Pro Glu Arg Gln Glu Ser Ala
        1875                1880                1885            
Glu His Glu Ala Ala His Ser Leu Thr Leu Gly Arg Tyr Glu Gln Met
    1890                1895                1900                
Glu Arg Arg Arg Glu Arg Arg Glu Arg Arg Leu Glu Arg Gln Glu Ser
1905                1910                1915                1920
Ser Glu Gln Glu Met Pro Ile Arg Gly Asp Leu Val Lys Gly Lys Ala
                1925                1930                1935    
Thr Leu Ala Asp Ile Val Glu Gln Leu Gln Glu Lys Glu Ala Gly Pro
            1940                1945                1950        
Gly Leu Pro Ala Gly Pro Ser Leu Pro Gln Pro Arg Glu Leu Pro Pro
        1955                1960                1965            
Gly Arg Leu Pro Asn Gly Leu Glu Leu Pro Glu Arg Thr Pro Arg Pro
    1970                1975                1980                
Asp Arg Pro Arg Ala Arg Asp Arg Pro Lys Pro Arg Arg
1985                1990                1995        


<210> 1014
<211> 362
<212> PRT
<213> Homo sapiens

<400> 1014
Met Gly Lys Val Arg Cys Gln Glu Pro His Cys Lys Leu Pro Val Val
 1               5                  10                  15      
Gly Ser Arg Gly Glu Val Ala Ala Glu Ile Trp Ala Asp Arg Arg Ala
            20                  25                  30          
Asp Ala Arg Gln Arg Leu Tyr Val Gly Pro Arg Ala Val Pro Gly Leu
        35                  40                  45              
Arg Pro Ser Ser Leu Val Leu Gly Leu Leu Trp Pro Leu Gly Met Gly
    50                  55                  60                  
Ala Trp Ser Pro Tyr Lys Ser His Pro Cys Val Thr Thr Asn Ser Ser
65                  70                  75                  80  
Asn Asn Ser Cys Pro Ala Val Pro Val His Phe Thr Ile Ser Thr Pro
                85                  90                  95      
Pro Ser Ile Pro Pro His Trp Gln Gly Leu Thr Ala Leu Val Leu Leu
            100                 105                 110         
His Ser Arg Ala His Gly Arg Thr Pro Arg Pro Thr Arg Ser Ser Gln
        115                 120                 125             
Thr His Thr Thr Leu Arg Lys Ala Pro Asn Trp Ser Asn Ser Gln Gln
    130                 135                 140                 
Trp Pro Ser Pro His Pro Pro Leu Ala Pro Pro Arg Ser Ser Phe Pro
145                 150                 155                 160 
Thr Phe Val Gly Lys Gly His Arg Asn Ala Gly Gln Leu Arg Arg Thr
                165                 170                 175     
Gly Gln Arg Arg Ala Thr Gly Pro Pro Gly Val Ser Phe Leu Ala Ala
            180                 185                 190         
Val Pro Leu Ile Thr Val Pro Gln Ser Ser Trp Gly Ser Arg Ala Pro
        195                 200                 205             
Arg Ala Ala Arg Ser Pro Arg Asp Asn Gly Ile Ile Ser Gly Glu Arg
    210                 215                 220                 
Gly Arg Leu Gly Pro Gly Leu Arg Arg Arg Arg Leu Leu Pro Ser Ile
225                 230                 235                 240 
Arg Pro Ser Ala Pro Lys Glu Arg Leu Arg Arg Pro Glu Thr Ser Gly
                245                 250                 255     
Ile Ser Asp Ala Gly Gly Ala Arg Val Ala Gly Pro Gly Arg Pro Asn
            260                 265                 270         
Ser Ile Ser Trp Ala Ala Ala Ala Ser Val Arg Leu Trp Ala Arg Arg
        275                 280                 285             
Asp Ser Ser Ser Gly Gln Leu Leu Phe Val His Glu Asp His Ala Tyr
    290                 295                 300                 
Gly Cys Gly Ser Ser Pro Phe Gly Ala His Pro Thr His Thr His Phe
305                 310                 315                 320 
Trp His Leu Arg Val Ala Pro Pro Ser His Ser Phe Pro Ala Arg Glu
                325                 330                 335     
Gly Asp Arg Gly Leu Pro Arg Lys Val Gly Lys Leu Trp Leu Leu Leu
            340                 345                 350         
Ser Ser Leu Trp Pro Ser Ser Glu Tyr Val
        355                 360         


<210> 1015
<211> 731
<212> PRT
<213> Homo sapiens

<400> 1015
Met Ala Ser Cys Pro Asp Ser Asp Asn Ser Trp Val Leu Ala Gly Ser
 1               5                  10                  15      
Glu Ser Leu Pro Val Glu Thr Leu Gly Pro Ala Ser Arg Met Asp Pro
            20                  25                  30          
Glu Ser Glu Arg Ala Leu Gln Ala Pro His Ser Pro Ser Lys Thr Asp
        35                  40                  45              
Gly Lys Glu Leu Ala Gly Thr Met Asp Gly Glu Gly Thr Leu Phe Gln
    50                  55                  60                  
Thr Glu Ser Pro Gln Ser Gly Ser Ile Leu Thr Glu Glu Thr Glu Val
65                  70                  75                  80  
Lys Gly Thr Leu Glu Gly Asp Val Cys Gly Val Glu Pro Pro Gly Pro
                85                  90                  95      
Gly Asp Thr Val Val Gln Gly Asp Leu Gln Glu Thr Thr Val Val Thr
            100                 105                 110         
Gly Leu Gly Pro Asp Thr Gln Asp Leu Glu Gly Gln Ser Pro Pro Gln
        115                 120                 125             
Ser Leu Pro Ser Thr Pro Lys Ala Ala Trp Ile Arg Glu Glu Gly Arg
    130                 135                 140                 
Cys Ser Ser Ser Asp Asp Asp Thr Asp Val Asp Met Glu Gly Leu Arg
145                 150                 155                 160 
Arg Arg Arg Gly Arg Glu Ala Gly Pro Pro Gln Pro Met Val Pro Leu
                165                 170                 175     
Ala Val Glu Asn Gln Ala Gly Gly Glu Gly Ala Gly Gly Glu Leu Gly
            180                 185                 190         
Ile Ser Leu Asn Met Cys Leu Leu Gly Ala Leu Val Leu Leu Gly Leu
        195                 200                 205             
Gly Val Leu Leu Phe Ser Gly Gly Leu Ser Glu Ser Glu Thr Gly Pro
    210                 215                 220                 
Met Glu Glu Val Glu Arg Gln Val Leu Pro Asp Pro Glu Val Leu Glu
225                 230                 235                 240 
Ala Val Gly Asp Arg Gln Asp Gly Leu Arg Glu Gln Leu Gln Ala Pro
                245                 250                 255     
Val Pro Pro Asp Ser Val Pro Ser Leu Gln Asn Met Gly Leu Leu Leu
            260                 265                 270         
Asp Lys Leu Ala Lys Glu Asn Gln Asp Ile Arg Leu Leu Gln Ala Gln
        275                 280                 285             
Leu Gln Ala Gln Lys Glu Glu Leu Gln Ser Leu Met His Gln Pro Lys
    290                 295                 300                 
Gly Leu Glu Glu Glu Asn Ala Gln Leu Arg Gly Ala Leu Gln Gln Gly
305                 310                 315                 320 
Glu Ala Phe Gln Arg Ala Leu Glu Ser Glu Leu Gln Gln Leu Arg Ala
                325                 330                 335     
Arg Leu Gln Gly Leu Glu Ala Asp Cys Val Arg Gly Pro Asp Gly Val
            340                 345                 350         
Cys Leu Ser Gly Asp Arg Gly Pro Gln Gly Asp Lys Ala Ile Arg Glu
        355                 360                 365             
Gln Gly Pro Arg Glu Gln Glu Pro Glu Leu Ser Phe Leu Lys Gln Lys
    370                 375                 380                 
Glu Gln Leu Glu Ala Glu Ala Gln Ala Leu Arg Gln Glu Leu Glu Arg
385                 390                 395                 400 
Gln Arg Arg Leu Leu Gly Ser Val Gln Gln Asp Leu Glu Arg Ser Leu
                405                 410                 415     
Gln Asp Ala Ser Arg Gly Asp Pro Ala His Ala Gly Leu Ala Glu Leu
            420                 425                 430         
Gly His Arg Leu Ala Gln Lys Leu Gln Gly Leu Glu Asn Trp Gly Gln
        435                 440                 445             
Asp Pro Gly Val Ser Ala Asn Ala Ser Lys Ala Trp His Gln Lys Ser
    450                 455                 460                 
His Phe Gln Asn Ser Arg Glu Trp Ser Gly Lys Glu Lys Trp Trp Asp
465                 470                 475                 480 
Gly Gln Arg Asp Arg Lys Ala Glu His Trp Lys His Lys Lys Glu Glu
                485                 490                 495     
Ser Gly Arg Glu Arg Lys Lys Asn Trp Gly Gly Gln Glu Asp Arg Glu
            500                 505                 510         
Pro Ala Gly Arg Trp Lys Glu Gly Arg Pro Arg Val Glu Glu Ser Gly
        515                 520                 525             
Ser Lys Lys Glu Gly Lys Arg Gln Gly Pro Lys Glu Pro Pro Arg Lys
    530                 535                 540                 
Ser Gly Ser Phe His Ser Ser Gly Glu Lys Gln Lys Gln Pro Arg Trp
545                 550                 555                 560 
Arg Glu Gly Thr Lys Asp Ser His Asp Pro Leu Pro Ser Trp Ala Glu
                565                 570                 575     
Leu Leu Arg Pro Lys Tyr Arg Ala Pro Gln Gly Cys Ser Gly Val Asp
            580                 585                 590         
Glu Cys Pro Arg Gln Glu Gly Leu Thr Phe Phe Gly Thr Glu Leu Ala
        595                 600                 605             
Pro Val Arg Gln Gln Glu Leu Ala Ser Leu Leu Arg Thr Tyr Leu Ala
    610                 615                 620                 
Arg Leu Pro Trp Ala Gly Gln Leu Thr Lys Glu Leu Pro Leu Ser Pro
625                 630                 635                 640 
Ala Phe Phe Gly Glu Asp Gly Ile Phe Arg His Asp Arg Leu Arg Phe
                645                 650                 655     
Arg Asp Phe Val Asp Ala Leu Glu Asp Ser Leu Glu Glu Val Ala Val
            660                 665                 670         
Gln Gln Thr Gly Asp Asp Asp Glu Val Asp Asp Phe Glu Asp Phe Ile
        675                 680                 685             
Phe Ser His Phe Phe Gly Asp Lys Ala Leu Lys Lys Arg Ser Gly Lys
    690                 695                 700                 
Lys Asp Lys His Ser Gln Ser Pro Arg Ala Ala Gly Pro Arg Glu Gly
705                 710                 715                 720 
His Ser His Ser His His His His His Arg Gly
                725                 730     


<210> 1016
<211> 145
<212> PRT
<213> Homo sapiens

<400> 1016
Met Glu Leu Val Gln Val Leu Lys Arg Gly Leu Gln Gln Ile Thr Gly
 1               5                  10                  15      
His Gly Gly Leu Arg Gly Tyr Leu Arg Val Phe Phe Arg Thr Asn Asp
            20                  25                  30          
Ala Lys Val Gly Thr Leu Val Gly Glu Asp Lys Tyr Gly Asn Lys Tyr
        35                  40                  45              
Tyr Glu Asp Asn Lys Gln Phe Phe Gly Arg His Arg Trp Val Val Tyr
    50                  55                  60                  
Thr Thr Glu Met Asn Gly Lys Asn Thr Phe Trp Asp Val Asp Gly Ser
65                  70                  75                  80  
Met Val Pro Pro Glu Trp His Arg Trp Leu His Ser Met Thr Asp Asp
                85                  90                  95      
Pro Pro Thr Thr Lys Pro Leu Thr Ala Arg Lys Phe Ile Trp Thr Asn
            100                 105                 110         
His Lys Phe Asn Val Thr Gly Thr Pro Glu Gln Tyr Val Pro Tyr Ser
        115                 120                 125             
Thr Thr Arg Lys Lys Ile Gln Glu Trp Ile Pro Pro Ser Thr Pro Tyr
    130                 135                 140                 
Lys
145 


<210> 1017
<211> 145
<212> PRT
<213> Homo sapiens

<400> 1017
Met Glu Leu Val Gln Val Leu Lys Arg Gly Leu Gln Gln Ile Thr Gly
 1               5                  10                  15      
His Gly Gly Leu Arg Gly Tyr Leu Arg Val Phe Phe Arg Thr Asn Asp
            20                  25                  30          
Ala Lys Val Gly Thr Leu Val Gly Glu Asp Lys Tyr Gly Asn Lys Tyr
        35                  40                  45              
Tyr Glu Asp Asn Lys Gln Phe Phe Gly Arg His Arg Trp Val Val Tyr
    50                  55                  60                  
Thr Thr Glu Met Asn Gly Lys Asn Thr Phe Trp Asp Val Asp Gly Ser
65                  70                  75                  80  
Met Val Pro Pro Glu Trp His Arg Trp Leu His Ser Met Thr Asp Asp
                85                  90                  95      
Pro Pro Thr Thr Lys Pro Leu Thr Ala Arg Lys Phe Ile Trp Thr Asn
            100                 105                 110         
His Lys Phe Asn Val Thr Gly Thr Pro Glu Gln Tyr Val Pro Tyr Ser
        115                 120                 125             
Thr Thr Arg Lys Lys Ile Gln Glu Trp Ile Pro Pro Ser Thr Pro Tyr
    130                 135                 140                 
Lys
145 


<210> 1018
<211> 302
<212> PRT
<213> Homo sapiens

<400> 1018
Ser Ser Ser Ser Thr Ala Ser Ala Ser Ala Lys Lys Ile Ile Val Lys
 1               5                  10                  15      
His Val Thr Val Ile Gly Gly Gly Leu Met Gly Ala Gly Ile Ala Gln
            20                  25                  30          
Val Ala Ala Ala Thr Gly His Thr Val Val Leu Val Asp Gln Thr Glu
        35                  40                  45              
Asp Ile Leu Ala Lys Ser Lys Lys Gly Ile Glu Glu Ser Leu Arg Lys
    50                  55                  60                  
Val Ala Lys Lys Lys Phe Ala Glu Asn Pro Lys Ala Gly Asp Glu Phe
65                  70                  75                  80  
Val Glu Lys Thr Leu Ser Thr Ile Ala Thr Ser Thr Asp Ala Ala Ser
                85                  90                  95      
Val Val His Ser Thr Asp Leu Val Val Glu Ala Ile Val Glu Asn Leu
            100                 105                 110         
Lys Val Lys Asn Glu Leu Phe Lys Arg Leu Asp Lys Phe Ala Ala Glu
        115                 120                 125             
His Thr Ile Phe Ala Ser Asn Thr Ser Ser Leu Gln Ile Thr Ser Ile
    130                 135                 140                 
Ala Asn Ala Thr Thr Arg Gln Asp Arg Phe Ala Gly Leu His Phe Phe
145                 150                 155                 160 
Asn Pro Val Pro Val Met Lys Leu Val Glu Val Ile Lys Thr Pro Met
                165                 170                 175     
Thr Ser Gln Lys Thr Phe Glu Ser Leu Val Asp Phe Ser Lys Ala Leu
            180                 185                 190         
Gly Lys His Pro Val Ser Cys Lys Asp Thr Pro Gly Phe Ile Val Asn
        195                 200                 205             
Arg Leu Leu Val Pro Tyr Leu Met Glu Ala Ile Arg Leu Tyr Glu Arg
    210                 215                 220                 
Gly Asp Ala Ser Lys Glu Asp Ile Asp Thr Ala Met Lys Leu Gly Ala
225                 230                 235                 240 
Gly Tyr Pro Met Gly Pro Phe Glu Leu Leu Asp Tyr Val Gly Leu Asp
                245                 250                 255     
Thr Thr Lys Phe Ile Val Asp Gly Trp His Glu Met Asp Ala Glu Asn
            260                 265                 270         
Pro Leu His Gln Pro Ser Pro Ser Leu Asn Lys Leu Val Ala Glu Asn
        275                 280                 285             
Lys Phe Gly Lys Lys Thr Gly Glu Gly Phe Tyr Lys Tyr Lys
    290                 295                 300         


<210> 1019
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1019
Gly Glu Phe Gly Val Tyr Leu Val Ser Asp Gly Ser Ser Arg Pro Tyr
 1               5                  10                  15      
Arg Cys Lys Ile Lys Ala Pro Gly Phe Ala His Leu
            20                  25              


<210> 1020
<211> 264
<212> PRT
<213> Homo sapiens

<400> 1020
Met Leu Ser His Asn Thr Met Met Lys Gln Arg Lys Gln Gln Ala Thr
 1               5                  10                  15      
Ala Ile Met Lys Glu Val His Gly Asn Asp Val Asp Gly Met Asp Leu
            20                  25                  30          
Gly Lys Lys Val Ser Ile Pro Arg Asp Ile Met Leu Glu Glu Leu Ser
        35                  40                  45              
His Leu Ser Asn Arg Gly Ala Arg Leu Phe Lys Met Arg Gln Arg Arg
    50                  55                  60                  
Ser Asp Lys Tyr Thr Phe Glu Asn Phe Gln Tyr Gln Ser Arg Ala Gln
65                  70                  75                  80  
Ile Asn His Ser Ile Ala Met Gln Asn Gly Lys Val Asp Gly Ser Asn
                85                  90                  95      
Leu Glu Gly Gly Ser Gln Gln Ala Pro Leu Thr Pro Pro Asn Thr Pro
            100                 105                 110         
Asp Pro Arg Ser Pro Pro Asn Pro Asp Asn Ile Ala Pro Gly Tyr Ser
        115                 120                 125             
Gly Pro Leu Lys Glu Ile Pro Pro Glu Lys Phe Asn Thr Thr Ala Val
    130                 135                 140                 
Pro Lys Tyr Tyr Gln Ser Pro Trp Glu Gln Ala Ile Ser Asn Asp Pro
145                 150                 155                 160 
Glu Leu Leu Glu Ala Leu Tyr Pro Lys Leu Phe Lys Pro Glu Gly Lys
                165                 170                 175     
Ala Glu Leu Pro Asp Tyr Arg Ser Phe Thr Arg Val Ala Thr Pro Phe
            180                 185                 190         
Gly Gly Phe Glu Lys Ala Ser Arg Met Val Lys Phe Lys Val Pro Asp
        195                 200                 205             
Phe Glu Leu Leu Leu Leu Thr Asp Pro Arg Phe Met Ser Phe Val Asn
    210                 215                 220                 
Pro Leu Ser Gly Arg Arg Ser Phe Asn Arg Thr Pro Lys Gly Trp Ile
225                 230                 235                 240 
Ser Glu Asn Ile Pro Ile Val Ile Thr Thr Glu Pro Thr Asp Asp Thr
                245                 250                 255     
Thr Val Pro Glu Ser Glu Asp Leu
            260                 


<210> 1021
<211> 117
<212> PRT
<213> Homo sapiens

<400> 1021
Met Lys Phe Gln Tyr Lys Glu Asp His Pro Phe Glu Tyr Arg Lys Lys
 1               5                  10                  15      
Glu Gly Glu Lys Ile Arg Lys Lys Tyr Pro Asp Arg Val Pro Val Ile
            20                  25                  30          
Val Glu Lys Ala Pro Lys Ala Arg Val Pro Asp Leu Asp Lys Arg Lys
        35                  40                  45              
Tyr Leu Val Pro Ser Asp Leu Thr Val Gly Gln Phe Tyr Phe Leu Ile
    50                  55                  60                  
Arg Lys Arg Ile His Leu Arg Pro Glu Asp Ala Leu Phe Phe Phe Val
65                  70                  75                  80  
Asn Asn Thr Ile Pro Pro Thr Ser Ala Thr Met Gly Gln Leu Tyr Glu
                85                  90                  95      
Asp Asn His Glu Glu Asp Tyr Phe Leu Tyr Val Ala Tyr Ser Asp Glu
            100                 105                 110         
Ser Val Tyr Gly Lys
        115         


<210> 1022
<211> 568
<212> PRT
<213> Homo sapiens

<400> 1022
Met Pro Ser Thr Asp Leu Leu Met Leu Lys Ala Phe Glu Pro Tyr Leu
 1               5                  10                  15      
Glu Ile Leu Glu Val Tyr Ser Thr Lys Ala Lys Asn Tyr Val Asn Gly
            20                  25                  30          
His Cys Thr Lys Tyr Glu Pro Trp Gln Leu Ile Ala Trp Ser Val Val
        35                  40                  45              
Trp Thr Leu Leu Ile Val Trp Gly Tyr Glu Phe Val Phe Gln Pro Glu
    50                  55                  60                  
Ser Leu Trp Ser Arg Phe Lys Lys Lys Cys Phe Lys Leu Thr Arg Lys
65                  70                  75                  80  
Met Pro Ile Ile Gly Arg Lys Ile Gln Asp Lys Leu Asn Lys Thr Lys
                85                  90                  95      
Asp Asp Ile Ser Lys Asn Met Ser Phe Leu Lys Val Asp Lys Glu Tyr
            100                 105                 110         
Val Lys Ala Leu Pro Ser Gln Gly Leu Ser Ser Ser Ala Val Leu Glu
        115                 120                 125             
Lys Leu Lys Glu Tyr Ser Ser Met Asp Ala Phe Trp Gln Glu Gly Arg
    130                 135                 140                 
Ala Ser Gly Thr Val Tyr Ser Gly Glu Glu Lys Leu Thr Glu Leu Leu
145                 150                 155                 160 
Val Lys Ala Tyr Gly Asp Phe Ala Trp Ser Asn Pro Leu His Pro Asp
                165                 170                 175     
Ile Phe Pro Gly Leu Arg Lys Ile Glu Ala Glu Ile Val Arg Ile Ala
            180                 185                 190         
Cys Ser Leu Phe Asn Gly Gly Pro Asp Ser Cys Gly Cys Val Thr Ser
        195                 200                 205             
Gly Gly Thr Glu Ser Ile Leu Met Ala Cys Lys Ala Tyr Arg Asp Leu
    210                 215                 220                 
Ala Phe Glu Lys Gly Ile Lys Thr Pro Glu Ile Val Ala Pro Gln Ser
225                 230                 235                 240 
Ala His Ala Ala Phe Asn Lys Ala Ala Ser Tyr Phe Gly Met Lys Ile
                245                 250                 255     
Val Arg Val Pro Leu Thr Lys Met Met Glu Val Asp Val Arg Ala Met
            260                 265                 270         
Arg Arg Ala Ile Ser Arg Asn Thr Ala Met Leu Val Cys Ser Thr Pro
        275                 280                 285             
Gln Phe Pro His Gly Val Ile Asp Pro Val Pro Glu Val Ala Lys Leu
    290                 295                 300                 
Ala Val Lys Tyr Lys Ile Pro Leu His Val Asp Ala Cys Leu Gly Gly
305                 310                 315                 320 
Phe Leu Ile Val Phe Met Glu Lys Ala Gly Tyr Pro Leu Glu His Pro
                325                 330                 335     
Phe Asp Phe Arg Val Lys Gly Val Thr Ser Ile Ser Ala Asp Thr His
            340                 345                 350         
Lys Tyr Gly Tyr Ala Pro Lys Gly Ser Ser Leu Val Leu Tyr Ser Asp
        355                 360                 365             
Lys Lys Tyr Arg Asn Tyr Gln Phe Phe Val Asp Thr Asp Trp Gln Gly
    370                 375                 380                 
Gly Ile Tyr Ala Ser Pro Thr Ile Ala Gly Ser Arg Pro Gly Gly Ile
385                 390                 395                 400 
Ser Ala Ala Ala Trp Ala Ala Leu Met His Phe Gly Glu Asn Gly Tyr
                405                 410                 415     
Val Glu Ala Thr Lys Gln Ile Ile Lys Thr Ala Arg Phe Leu Lys Ser
            420                 425                 430         
Glu Leu Glu Asn Ile Lys Gly Ile Phe Val Phe Gly Asn Pro Gln Leu
        435                 440                 445             
Ser Val Ile Ala Leu Gly Ser Arg Asp Phe Asp Ile Tyr Arg Leu Ser
    450                 455                 460                 
Asn Leu Met Thr Ala Lys Gly Trp Asn Leu Asn Gln Leu Gln Phe Pro
465                 470                 475                 480 
Pro Ser Ile His Phe Cys Ile Thr Leu Leu His Ala Arg Lys Arg Val
                485                 490                 495     
Ala Ile Gln Phe Leu Lys Asp Ile Arg Glu Ser Val Thr Gln Ile Met
            500                 505                 510         
Lys Asn Pro Lys Ala Lys Thr Thr Gly Met Gly Ala Ile Tyr Gly Met
        515                 520                 525             
Ala Gln Thr Thr Val Asp Arg Asn Met Val Ala Glu Leu Ser Ser Val
    530                 535                 540                 
Phe Leu Asp Ser Leu Tyr Ser Thr Asp Thr Val Thr Gln Gly Ser Gln
545                 550                 555                 560 
Met Asn Gly Ser Pro Lys Pro His
                565             


<210> 1023
<211> 748
<212> PRT
<213> Homo sapiens

<400> 1023
Met Ser Ser Gly Gly Arg Phe Asn Phe Asp Asp Gly Gly Ser Tyr Cys
 1               5                  10                  15      
Gly Gly Trp Glu Asp Gly Lys Ala His Gly His Gly Val Cys Thr Gly
            20                  25                  30          
Pro Lys Gly Gln Gly Glu Tyr Thr Gly Ser Trp Ser His Gly Phe Glu
        35                  40                  45              
Val Leu Gly Val Tyr Thr Trp Pro Ser Gly Asn Thr Tyr Gln Gly Thr
    50                  55                  60                  
Trp Ala Gln Gly Lys Arg His Gly Ile Gly Leu Glu Ser Lys Gly Lys
65                  70                  75                  80  
Trp Val Tyr Lys Gly Glu Trp Thr His Gly Phe Lys Gly Arg Tyr Gly
                85                  90                  95      
Val Arg Glu Cys Ala Gly Asn Gly Ala Lys Tyr Glu Gly Thr Trp Ser
            100                 105                 110         
Asn Gly Leu Gln Asp Gly Tyr Gly Thr Glu Thr Tyr Ser Asp Gly Gly
        115                 120                 125             
Thr Tyr Gln Gly Gln Trp Val Gly Gly Met Arg Gln Gly Tyr Gly Val
    130                 135                 140                 
Arg Gln Ser Val Pro Tyr Gly Met Ala Ala Val Ile Arg Ser Pro Leu
145                 150                 155                 160 
Arg Thr Ser Ile Asn Ser Leu Arg Ser Glu His Thr Asn Gly Thr Pro
                165                 170                 175     
Leu His Pro Asp Ala Ser Pro Ala Val Asp Gly Ser Pro Ala Val Ser
            180                 185                 190         
Arg Gly Gly Phe Val Leu Val Ala His Ser Asp Ser Glu Ile Leu Lys
        195                 200                 205             
Ser Lys Lys Lys Gly Leu Phe Arg Arg Ser Leu Leu Ser Gly Leu Lys
    210                 215                 220                 
Leu Arg Lys Ser Glu Ser Lys Ser Ser Leu Ala Ser Gln Arg Ser Lys
225                 230                 235                 240 
Gln Ser Ser Phe Arg Ser Glu Ala Gly Met Ser Thr Val Ser Ser Thr
                245                 250                 255     
Ala Ser Asp Ile His Ser Thr Ile Ser Leu Gly Glu Ala Glu Ala Glu
            260                 265                 270         
Leu Ala Val Ile Glu Asp Asp Ile Asp Ala Thr Thr Thr Glu Thr Tyr
        275                 280                 285             
Val Gly Glu Trp Lys Asn Asp Lys Arg Ser Gly Phe Gly Val Ser Gln
    290                 295                 300                 
Arg Ser Asp Gly Leu Lys Tyr Glu Gly Glu Trp Ala Ser Asn Arg Arg
305                 310                 315                 320 
His Gly Tyr Gly Cys Met Thr Phe Pro Asp Gly Thr Lys Glu Glu Gly
                325                 330                 335     
Lys Tyr Lys Gln Asn Ile Leu Val Gly Gly Lys Arg Lys Asn Leu Ile
            340                 345                 350         
Pro Leu Arg Ala Ser Lys Ile Arg Glu Lys Val Asp Arg Ala Val Glu
        355                 360                 365             
Ala Ala Glu Arg Ala Ala Thr Ile Ala Lys Gln Lys Ala Glu Ile Ala
    370                 375                 380                 
Ala Ser Arg Thr Ser His Ser Arg Ala Lys Ala Glu Ala Ala Leu Thr
385                 390                 395                 400 
Ala Ala Gln Lys Ala Gln Glu Glu Ala Arg Ile Ala Arg Ile Thr Ala
                405                 410                 415     
Lys Glu Phe Ser Pro Ser Phe Gln His Arg Glu Asn Gly Leu Glu Tyr
            420                 425                 430         
Gln Arg Pro Lys Arg Gln Thr Ser Cys Asp Asp Ile Glu Val Leu Ser
        435                 440                 445             
Thr Gly Thr Pro Leu Gln Gln Glu Ser Pro Glu Leu Tyr Arg Lys Gly
    450                 455                 460                 
Thr Thr Pro Ser Asp Leu Thr Pro Asp Asp Ser Pro Leu Gln Ser Phe
465                 470                 475                 480 
Pro Thr Ser Pro Ala Ala Thr Pro Pro Pro Ala Pro Ala Ala Arg Asn
                485                 490                 495     
Lys Val Ala His Phe Ser Arg Gln Val Ser Val Asp Glu Glu Arg Gly
            500                 505                 510         
Gly Asp Ile Gln Met Leu Leu Glu Gly Arg Ala Gly Asp Cys Ala Arg
        515                 520                 525             
Ser Ser Trp Gly Glu Glu Gln Ala Gly Gly Ser Arg Gly Val Arg Ser
    530                 535                 540                 
Gly Ala Leu Arg Gly Gly Leu Leu Val Asp Asp Phe Arg Thr Arg Gly
545                 550                 555                 560 
Ser Gly Arg Lys Gln Pro Gly Asn Pro Lys Pro Arg Glu Arg Arg Thr
                565                 570                 575     
Glu Ser Pro Pro Val Phe Thr Trp Thr Ser His His Arg Ala Ser Asn
            580                 585                 590         
His Ser Pro Gly Gly Ser Arg Leu Leu Glu Leu Gln Glu Glu Lys Leu
        595                 600                 605             
Ser Asn Tyr Arg Met Glu Met Lys Pro Leu Leu Arg Met Glu Thr His
    610                 615                 620                 
Pro Gln Lys Arg Arg Tyr Ser Lys Gly Gly Ala Cys Arg Gly Leu Gly
625                 630                 635                 640 
Asp Asp His Arg Pro Glu Asp Arg Gly Phe Gly Val Gln Arg Leu Arg
                645                 650                 655     
Ser Lys Ala Gln Asn Lys Glu Asn Phe Arg Pro Ala Ser Ser Ala Glu
            660                 665                 670         
Pro Ala Val Gln Lys Leu Ala Ser Leu Arg Leu Gly Gly Ala Glu Pro
        675                 680                 685             
Arg Leu Leu Arg Trp Asp Leu Thr Phe Ser Pro Pro Gln Lys Ser Leu
    690                 695                 700                 
Pro Val Ala Leu Glu Ser Asp Glu Glu Asn Gly Asp Glu Leu Lys Ser
705                 710                 715                 720 
Ser Thr Gly Ser Ala Pro Ile Leu Val Val Met Val Ile Leu Leu Asn
                725                 730                 735     
Ile Gly Val Ala Ile Leu Phe Ile Asn Phe Phe Ile
            740                 745             


<210> 1024
<211> 183
<212> PRT
<213> Homo sapiens

<400> 1024
Arg Asn Gln Thr Ser Ile Ser Gln Trp Val Pro Val Cys Ser Arg Leu
 1               5                  10                  15      
Ile Pro Val Ser Pro Thr Gln Gly Gln Gly Asp Arg Ala Leu Ser Arg
            20                  25                  30          
Thr Ser Gln Trp Pro Gln Met Ser Gln Ser Arg Ala Cys Gly Gly Ser
        35                  40                  45              
Glu Gln Ile Pro Gly Ile Asp Ile Gln Leu Asn Arg Lys Tyr His Thr
    50                  55                  60                  
Thr Arg Lys Leu Ser Thr Thr Lys Asp Ser Pro Gln Pro Val Glu Glu
65                  70                  75                  80  
Lys Val Gly Ala Phe Thr Lys Ile Ile Glu Ala Met Gly Phe Thr Gly
                85                  90                  95      
Pro Leu Lys Tyr Ser Lys Trp Lys Ile Lys Ile Ala Ala Leu Arg Met
            100                 105                 110         
Tyr Thr Ser Cys Val Glu Lys Thr Asp Phe Glu Glu Phe Phe Leu Arg
        115                 120                 125             
Cys Gln Met Pro Asp Thr Phe Asn Ser Trp Phe Leu Ile Thr Leu Leu
    130                 135                 140                 
His Val Trp Met Cys Leu Val Arg Met Lys Gln Glu Gly Arg Ser Gly
145                 150                 155                 160 
Lys Tyr Met Cys Arg Ile Ile Val His Phe Met Trp Glu Asp Val Gln
                165                 170                 175     
Gln Arg Gly Arg Val Met Gly
            180             


<210> 1025
<211> 768
<212> PRT
<213> Homo sapiens

<400> 1025
Ala Ser Gly Ser Gly Ser Ser Gly Asp Ser Leu Asp Lys Ser Ile Thr
 1               5                  10                  15      
Leu Pro Pro Asp Glu Ile Phe Arg Asn Leu Glu Asn Ala Lys Arg Phe
            20                  25                  30          
Ala Ile Asp Ile Gly Gly Ser Leu Thr Lys Leu Ala Tyr Tyr Ser Thr
        35                  40                  45              
Val Gln His Lys Val Ala Lys Val Arg Ser Phe Asp His Ser Gly Lys
    50                  55                  60                  
Asp Thr Glu Arg Glu His Glu Pro Pro Tyr Glu Ile Ser Val Gln Glu
65                  70                  75                  80  
Glu Ile Thr Ala Arg Leu His Phe Ile Lys Phe Glu Asn Thr Tyr Ile
                85                  90                  95      
Glu Ala Cys Leu Asp Phe Ile Lys Asp His Leu Val Asn Thr Glu Thr
            100                 105                 110         
Lys Val Ile Gln Ala Thr Gly Gly Gly Ala Tyr Lys Phe Lys Asp Leu
        115                 120                 125             
Ile Glu Glu Lys Leu Arg Leu Lys Val Asp Lys Glu Asp Val Met Thr
    130                 135                 140                 
Cys Leu Ile Lys Gly Cys Asn Phe Val Leu Lys Asn Ile Pro His Glu
145                 150                 155                 160 
Ala Phe Val Tyr Gln Lys Asp Ser Asp Pro Glu Phe Arg Phe Gln Thr
                165                 170                 175     
Asn His Pro His Ile Phe Pro Tyr Leu Leu Val Asn Ile Gly Ser Gly
            180                 185                 190         
Val Ser Ile Val Lys Val Glu Thr Glu Asp Arg Phe Glu Trp Val Gly
        195                 200                 205             
Gly Ser Ser Ile Gly Gly Gly Thr Phe Trp Gly Leu Gly Ala Leu Leu
    210                 215                 220                 
Thr Lys Thr Lys Lys Phe Asp Glu Leu Leu His Leu Ala Ser Arg Gly
225                 230                 235                 240 
Gln His Ser Asn Val Asp Met Leu Val Arg Asp Val Tyr Gly Gly Ala
                245                 250                 255     
His Gln Thr Leu Gly Leu Ser Gly Asn Leu Ile Ala Ser Ser Phe Gly
            260                 265                 270         
Lys Ser Ala Thr Ala Asp Gln Glu Phe Ser Lys Glu Asp Met Ala Lys
        275                 280                 285             
Ser Leu Leu His Met Ile Ser Asn Asp Ile Gly Gln Leu Ala Cys Leu
    290                 295                 300                 
His Ala Arg Leu His Ser Leu Asp Arg Val Tyr Phe Gly Gly Phe Phe
305                 310                 315                 320 
Ile Arg Gly His Pro Val Thr Met Arg Thr Ile Thr Tyr Ser Ile Asn
                325                 330                 335     
Phe Phe Ser Lys Gly Glu Val Gln Ala Leu Phe Leu Arg His Glu Gly
            340                 345                 350         
Tyr Leu Gly Ala Ile Gly Ala Phe Leu Lys Gly Ala Glu Gln Asp Asn
        355                 360                 365             
Pro Asn Gln Tyr Ser Trp Gly Glu Asn Tyr Ala Gly Ser Ser Gly Leu
    370                 375                 380                 
Met Ser Ala Ser Pro Glu Leu Gly Pro Ala Gln Arg Ala Arg Ser Gly
385                 390                 395                 400 
Thr Phe Asp Leu Leu Glu Met Asp Arg Leu Glu Arg Pro Leu Val Asp
                405                 410                 415     
Leu Pro Leu Leu Leu Asp Pro Pro Ser Tyr Val Pro Asp Thr Val Asp
            420                 425                 430         
Leu Thr Asp Asp Ala Leu Ala Arg Lys Tyr Trp Leu Thr Cys Phe Glu
        435                 440                 445             
Glu Ala Leu Asp Gly Val Val Lys Arg Ala Val Ala Ser Gln Pro Asp
    450                 455                 460                 
Ser Val Asp Ala Ala Glu Arg Ala Glu Lys Phe Arg Gln Lys Tyr Trp
465                 470                 475                 480 
Asn Lys Leu Gln Thr Leu Arg Gln Gln Pro Phe Ala Tyr Gly Thr Leu
                485                 490                 495     
Thr Val Arg Ser Leu Leu Asp Thr Arg Glu His Cys Leu Asn Glu Phe
            500                 505                 510         
Asn Phe Pro Asp Pro Tyr Ser Lys Val Lys Gln Arg Glu Asn Gly Val
        515                 520                 525             
Ala Leu Arg Cys Phe Pro Gly Val Val Arg Ser Leu Asp Val Leu Gly
    530                 535                 540                 
Trp Glu Glu Arg Gln Leu Ala Leu Val Lys Gly Leu Leu Ala Gly Asn
545                 550                 555                 560 
Val Phe Asp Trp Gly Ala Lys Ala Val Ser Ala Val Leu Glu Ser Asp
                565                 570                 575     
Pro Tyr Phe Gly Phe Glu Glu Ala Lys Arg Lys Leu Gln Glu Arg Pro
            580                 585                 590         
Trp Leu Val Asp Ser Tyr Ser Glu Trp Leu Gln Arg Leu Lys Gly Pro
        595                 600                 605             
Pro His Lys Cys Ala Leu Ile Phe Ala Asp Asn Ser Gly Ile Asp Ile
    610                 615                 620                 
Ile Leu Gly Val Phe Pro Phe Val Arg Glu Leu Leu Leu Arg Gly Thr
625                 630                 635                 640 
Glu Val Ile Leu Ala Cys Asn Ser Gly Pro Ala Leu Asn Asp Val Thr
                645                 650                 655     
His Ser Glu Ser Leu Ile Val Ala Glu Arg Ile Ala Gly Met Asp Pro
            660                 665                 670         
Val Val His Ser Ala Leu Gln Glu Glu Arg Leu Leu Leu Val Gln Thr
        675                 680                 685             
Gly Ser Ser Ser Pro Cys Leu Asp Leu Ser Arg Leu Asp Lys Gly Leu
    690                 695                 700                 
Ala Ala Leu Val Arg Glu Arg Gly Ala Asp Leu Val Val Ile Glu Gly
705                 710                 715                 720 
Met Gly Arg Ala Val His Thr Asn Tyr His Ala Ala Leu Arg Cys Glu
                725                 730                 735     
Ser Leu Lys Leu Ala Val Ile Lys Asn Ala Trp Leu Ala Glu Arg Leu
            740                 745                 750         
Gly Gly Arg Leu Phe Ser Val Ile Phe Lys Tyr Glu Val Pro Ala Glu
        755                 760                 765             


<210> 1026
<211> 163
<212> PRT
<213> Homo sapiens

<400> 1026
Met Thr Gly Asp Lys Gly Pro Gln Arg Leu Ser Gly Ser Ser Tyr Gly
 1               5                  10                  15      
Ser Ile Ser Ser Pro Thr Ser Pro Thr Ser Pro Gly Pro Gln Gln Ala
            20                  25                  30          
Pro Pro Arg Glu Thr Tyr Leu Ser Glu Lys Ile Pro Ile Pro Asp Thr
        35                  40                  45              
Lys Pro Gly Thr Phe Ser Leu Arg Lys Leu Trp Ala Phe Thr Gly Pro
    50                  55                  60                  
Gly Phe Leu Met Ser Ile Ala Phe Leu Asp Pro Gly Asn Ile Glu Ser
65                  70                  75                  80  
Asp Leu Gln Ala Gly Ala Val Ala Gly Phe Lys Leu Leu Trp Val Leu
                85                  90                  95      
Leu Trp Ala Thr Val Leu Gly Leu Leu Cys Gln Arg Leu Ala Ala Arg
            100                 105                 110         
Leu Gly Val Val Thr Gly Lys Asp Leu Gly Glu Val Cys His Leu Tyr
        115                 120                 125             
Tyr Pro Lys Ser Glu Ser Arg Ser Val Ala Gln Ser Gly Val Gln Trp
    130                 135                 140                 
Cys Asp Val Ser Ser Leu Gln Pro Leu Pro Pro Arg Cys Pro Ala Pro
145                 150                 155                 160 
Ser Ser Gly
            


<210> 1027
<211> 744
<212> PRT
<213> Homo sapiens

<400> 1027
Met Ala Gly Arg Ser Met Gln Ala Ala Arg Cys Pro Thr Asp Glu Leu
 1               5                  10                  15      
Ser Leu Thr Asn Cys Ala Val Val Asn Glu Lys Asp Phe Gln Ser Gly
            20                  25                  30          
Gln His Val Ile Val Arg Thr Ser Pro Asn His Arg Tyr Thr Phe Thr
        35                  40                  45              
Leu Lys Thr His Pro Ser Val Val Pro Gly Ser Ile Ala Phe Ser Leu
    50                  55                  60                  
Pro Gln Arg Lys Trp Ala Gly Leu Ser Ile Gly Gln Glu Ile Glu Val
65                  70                  75                  80  
Ser Leu Tyr Thr Phe Asp Lys Ala Lys Gln Cys Ile Gly Thr Met Thr
                85                  90                  95      
Ile Glu Ile Asp Phe Leu Gln Lys Lys Ser Asn Asp Ser Asn Pro Tyr
            100                 105                 110         
Asp Thr Asp Lys Met Ala Ala Glu Phe Ile Gln Gln Phe Asn Asn Gln
        115                 120                 125             
Ala Tyr Ser Val Gly Gln Gln Leu Val Phe Ser Phe Asn Glu Lys Leu
    130                 135                 140                 
Phe Gly Leu Leu Val Lys Asp Ile Glu Ser Met Asp Pro Ser Ile Leu
145                 150                 155                 160 
Lys Gly Glu Pro Ala Thr Gly Lys Arg Gln Lys Ile Glu Val Gly Leu
                165                 170                 175     
Val Val Gly Asn Ser Gln Val Ala Phe Glu Lys Ala Glu Asn Ser Ser
            180                 185                 190         
Leu Asn Leu Ile Gly Lys Ala Lys Thr Lys Glu Asn Arg Gln Ser Ile
        195                 200                 205             
Ile Asn Pro Asp Trp Asn Phe Glu Lys Met Gly Ile Gly Gly Leu Asp
    210                 215                 220                 
Lys Glu Phe Ser Asp Ile Phe Arg Arg Ala Phe Ala Phe Arg Val Phe
225                 230                 235                 240 
Pro Pro Glu Ile Val Glu Gln Met Gly Cys Ile His Val Lys Gly Ile
                245                 250                 255     
Leu Leu Tyr Gly Pro Pro Gly Cys Gly Lys Thr Leu Leu Ala Arg Gln
            260                 265                 270         
Ile Gly Lys Met Leu Asn Ala Arg Glu Pro Lys Val Val Asn Gly Pro
        275                 280                 285             
Glu Ile Leu Asn Lys Tyr Val Gly Glu Ser Glu Ala Asn Ile Arg Lys
    290                 295                 300                 
Leu Phe Ala Asp Ala Glu Glu Glu Gln Arg Arg Leu Gly Ala Asn Ser
305                 310                 315                 320 
Gly Leu His Ile Ile Ile Phe Asp Glu Ile Asp Ala Ile Cys Lys Gln
                325                 330                 335     
Arg Gly Ser Met Ala Gly Ser Thr Gly Val His Asp Thr Val Val Asn
            340                 345                 350         
Gln Leu Leu Ser Lys Ile Asp Gly Val Glu Gln Leu Asn Asn Ile Leu
        355                 360                 365             
Val Ile Gly Met Thr Asn Arg Pro Asp Leu Ile Asp Glu Ala Leu Leu
    370                 375                 380                 
Arg Pro Gly Arg Leu Glu Val Lys Met Glu Ile Gly Leu Pro Asp Glu
385                 390                 395                 400 
Lys Gly Arg Leu Gln Ile Leu His Ile His Thr Ala Arg Met Arg Gly
                405                 410                 415     
His Gln Leu Leu Ser Ala Asp Val Asp Ile Lys Glu Leu Ala Val Glu
            420                 425                 430         
Thr Lys Asn Phe Ser Gly Ala Glu Leu Glu Gly Leu Val Arg Ala Ala
        435                 440                 445             
Gln Ser Thr Ala Met Asn Arg His Ile Lys Ala Ser Thr Lys Val Glu
    450                 455                 460                 
Val Asp Met Glu Lys Ala Glu Ser Leu Gln Val Thr Arg Gly Asp Phe
465                 470                 475                 480 
Leu Ala Ser Leu Glu Asn Asp Ile Lys Pro Ala Phe Gly Thr Asn Gln
                485                 490                 495     
Glu Asp Tyr Ala Ser Tyr Ile Met Asn Gly Ile Ile Lys Trp Gly Asp
            500                 505                 510         
Pro Val Thr Arg Val Leu Asp Asp Gly Glu Leu Leu Val Gln Gln Thr
        515                 520                 525             
Lys Asn Ser Asp Arg Thr Pro Leu Val Ser Val Leu Leu Glu Gly Pro
    530                 535                 540                 
Pro His Ser Gly Lys Thr Ala Leu Ala Ala Lys Ile Ala Glu Glu Ser
545                 550                 555                 560 
Asn Phe Pro Phe Ile Lys Ile Cys Ser Pro Glu Lys Met Ile Gly Phe
                565                 570                 575     
Ser Glu Thr Ala Lys Cys Gln Ala Met Lys Lys Ile Phe Asp Asp Ala
            580                 585                 590         
Tyr Lys Ser Gln Leu Ser Cys Val Val Val Asp Asp Ile Glu Arg Leu
        595                 600                 605             
Leu Asp Tyr Val Pro Ile Gly Pro Arg Phe Ser Asn Leu Val Leu Gln
    610                 615                 620                 
Ala Leu Leu Val Leu Leu Lys Lys Ala Pro Pro Gln Gly Arg Lys Leu
625                 630                 635                 640 
Leu Ile Ile Gly Thr Thr Ser Arg Lys Asp Val Leu Gln Glu Met Glu
                645                 650                 655     
Met Leu Asn Ala Phe Ser Thr Thr Ile His Val Pro Asn Ile Ala Thr
            660                 665                 670         
Gly Glu Gln Leu Leu Glu Ala Leu Glu Leu Leu Gly Asn Leu Lys Asp
        675                 680                 685             
Lys Glu Arg Thr Thr Ile Ala Gln Gln Val Lys Gly Lys Lys Val Trp
    690                 695                 700                 
Ile Gly Ile Lys Lys Leu Leu Met Leu Ile Glu Met Ser Leu Gln Met
705                 710                 715                 720 
Asp Pro Glu Tyr Arg Val Arg Lys Phe Leu Ala Leu Leu Arg Glu Glu
                725                 730                 735     
Gly Ala Ser Pro Leu Asp Phe Asp
            740                 


<210> 1028
<211> 229
<212> PRT
<213> Homo sapiens

<400> 1028
Lys Val Ile His Met Phe Ser Thr Ala Glu Gly Leu Leu Thr Gln Gly
 1               5                  10                  15      
Asp Lys Ile Thr Ala Asp Gly Leu Gln Glu Val Phe Glu Thr Asp Val
            20                  25                  30          
Phe Gly His Phe Ile Leu Ile Arg Glu Leu Glu Pro Leu Leu Cys His
        35                  40                  45              
Ser Asp Asn Pro Ser Gln Leu Ile Trp Thr Ser Ser Arg Asn Ala Arg
    50                  55                  60                  
Lys Ser Asn Phe Ser Leu Glu Asp Phe Gln His Ser Lys Gly Lys Glu
65                  70                  75                  80  
Pro Tyr Ser Ser Ser Lys Tyr Ala Thr Asp Leu Leu Ser Val Ala Leu
                85                  90                  95      
Asn Arg Asn Phe Gln Pro Ala Gly Ser Leu Phe Gln Cys Gly Leu Ser
            100                 105                 110         
Arg Tyr Ser Ile Asp Gln Phe Asp Ile Trp Asn Ser Ala Ser Val Tyr
        115                 120                 125             
Met Asp Thr Val Asp Ala Gly Asn Ile Leu Arg Phe Phe Ala Asn Ala
    130                 135                 140                 
Phe Thr Leu Thr Pro Tyr Asn Gly Thr Glu Ala Leu Val Trp Leu Phe
145                 150                 155                 160 
His Gln Lys Pro Glu Ser Val Asn Pro Leu Ile Lys Tyr Leu Ser Ala
                165                 170                 175     
Thr Thr Gly Phe Gly Arg Asn Tyr Ile Met Thr Gln Lys Met Asp Leu
            180                 185                 190         
Asp Glu Asp Thr Ala Glu Lys Phe Tyr Gln Lys Leu Leu Glu Leu Glu
        195                 200                 205             
Lys His Ile Arg Val Thr Ile Gln Lys Thr Asp Asn Gln Ala Arg Leu
    210                 215                 220                 
Ser Gly Ser Cys Leu
225                 


<210> 1029
<211> 114
<212> PRT
<213> Homo sapiens

<400> 1029
Glu Ser Gly Leu Gly Lys Leu Thr Leu Ile Asn Ser Leu Phe Leu Thr
 1               5                  10                  15      
Asp Leu Tyr Ser Pro Glu Tyr Pro Gly Pro Ser Gln Arg Ile Lys Lys
            20                  25                  30          
Pro Val Gln Met Glu Gln Ser Lys Val Leu Ile Lys Glu Gly Gly Val
        35                  40                  45              
Gln Leu Leu Leu Thr Ile Val Asp Thr Pro Gly Phe Gly Asp Ala Val
    50                  55                  60                  
Asp Asn Ser Asn Cys Trp Gln Pro Ala Ile Asn Tyr Ile Asp Ser Lys
65                  70                  75                  80  
Phe Glu Asp Tyr Leu Asn Ala Glu Ser Arg Val Asn Arg Cys Gln Met
                85                  90                  95      
Pro Gly Asn Arg Val Gln Cys Cys Leu Tyr Phe Ile Ala Pro Ser Gly
            100                 105                 110         
His Gly
        


<210> 1030
<211> 373
<212> PRT
<213> Homo sapiens

<400> 1030
Glu Ser Val Thr Phe Gln Asp Val Ala Val Asp Phe Thr Ala Glu Glu
 1               5                  10                  15      
Trp Gln Leu Leu Asp Cys Ala Glu Arg Thr Leu Tyr Trp Asp Val Met
            20                  25                  30          
Leu Glu Asn Tyr Arg Asn Leu Ile Ser Val Gly Cys Pro Ile Thr Lys
        35                  40                  45              
Thr Lys Val Ile Leu Lys Val Glu Gln Gly Gln Glu Pro Trp Met Val
    50                  55                  60                  
Glu Gly Ala Asn Pro His Glu Ser Ser Pro Glu Ser Asp Tyr Pro Leu
65                  70                  75                  80  
Val Asp Glu Pro Gly Lys His Arg Glu Ser Lys Asp Asn Phe Leu Lys
                85                  90                  95      
Ser Val Leu Leu Thr Phe Asn Lys Ile Leu Thr Met Glu Arg Ile His
            100                 105                 110         
His Tyr Asn Met Ser Thr Ser Leu Asn Pro Met Arg Lys Lys Ser Tyr
        115                 120                 125             
Lys Ser Phe Glu Lys Cys Leu Pro Pro Asn Leu Asp Leu Leu Lys Tyr
    130                 135                 140                 
Asn Arg Ser Tyr Thr Val Glu Asn Ala Tyr Glu Cys Ser Glu Cys Gly
145                 150                 155                 160 
Lys Ala Phe Lys Lys Lys Phe His Phe Ile Arg His Glu Lys Asn His
                165                 170                 175     
Thr Arg Lys Lys Pro Phe Glu Cys Asn Asp Cys Gly Lys Ala Tyr Ser
            180                 185                 190         
Arg Lys Ala His Leu Ala Thr His Gln Lys Ile His Asn Gly Glu Arg
        195                 200                 205             
Pro Phe Val Cys Asn Asp Cys Gly Lys Ala Phe Met His Lys Ala Gln
    210                 215                 220                 
Leu Val Val His Gln Arg Leu His Thr Gly Glu Lys Pro Tyr Glu Cys
225                 230                 235                 240 
Ser Gln Cys Gly Lys Thr Phe Thr Trp Asn Ser Ser Phe Asn Gln His
                245                 250                 255     
Val Lys Ser His Thr Leu Glu Lys Ser Phe Glu Cys Lys Glu Cys Gly
            260                 265                 270         
Lys Thr Phe Arg Tyr Ser Ser Ser Leu Tyr Lys His Ser Arg Phe His
        275                 280                 285             
Thr Gly Glu Lys Pro Tyr Gln Cys Ile Ile Cys Gly Lys Ala Phe Gly
    290                 295                 300                 
Asn Thr Ser Val Leu Val Thr His Gln Arg Ile His Thr Gly Glu Lys
305                 310                 315                 320 
Pro Tyr Ser Cys Ile Glu Cys Gly Lys Ala Phe Ile Lys Lys Ser His
                325                 330                 335     
Leu Leu Arg His Gln Ile Thr His Thr Gly Glu Lys Pro Tyr Glu Cys
            340                 345                 350         
Asn Arg Cys Gly Lys Ala Phe Ser Gln Lys Ser Asn Leu Ile Val His
        355                 360                 365             
Gln Lys Ile His Thr
    370             


<210> 1031
<211> 260
<212> PRT
<213> Homo sapiens

<400> 1031
Met Ala Ser Ser Gly Met Thr Arg Arg Asp Pro Leu Ala Asn Lys Val
 1               5                  10                  15      
Ala Leu Val Thr Ala Ser Thr Asp Gly Ile Gly Phe Ala Ile Ala Arg
            20                  25                  30          
Arg Leu Ala Gln Asp Gly Ala His Val Val Val Ser Ser Arg Lys Gln
        35                  40                  45              
Gln Asn Val Asp Gln Ala Val Ala Thr Leu Gln Gly Glu Gly Leu Ser
    50                  55                  60                  
Val Thr Gly Thr Val Cys His Val Gly Lys Ala Glu Asp Arg Glu Arg
65                  70                  75                  80  
Leu Val Ala Met Ala Val Lys Leu His Gly Gly Ile Asp Ile Leu Val
                85                  90                  95      
Ser Asn Ala Ala Val Asn Pro Phe Phe Gly Ser Leu Met Asp Val Thr
            100                 105                 110         
Glu Glu Val Trp Asp Lys Thr Leu Asp Ile Asn Val Lys Ala Pro Ala
        115                 120                 125             
Leu Met Thr Lys Ala Val Val Pro Glu Met Glu Lys Arg Gly Gly Gly
    130                 135                 140                 
Ser Val Val Ile Val Ser Ser Ile Ala Ala Phe Ser Pro Ser Pro Gly
145                 150                 155                 160 
Phe Ser Pro Tyr Asn Val Ser Lys Thr Ala Leu Leu Gly Leu Thr Lys
                165                 170                 175     
Thr Leu Ala Ile Glu Leu Ala Pro Arg Asn Ile Arg Val Asn Cys Leu
            180                 185                 190         
Ala Pro Gly Leu Ile Lys Thr Ser Phe Ser Arg Met Leu Trp Met Asp
        195                 200                 205             
Lys Glu Lys Glu Glu Ser Met Lys Glu Thr Leu Arg Ile Arg Arg Leu
    210                 215                 220                 
Gly Glu Pro Glu Asp Cys Ala Gly Ile Val Ser Phe Leu Cys Ser Glu
225                 230                 235                 240 
Asp Ala Ser Tyr Ile Thr Gly Glu Thr Val Val Val Gly Gly Gly Thr
                245                 250                 255     
Pro Ser Arg Leu
            260 


<210> 1032
<211> 421
<212> PRT
<213> Homo sapiens

<400> 1032
Met Asp Leu Glu Asn Lys Val Lys Lys Met Gly Leu Gly His Glu Gln
 1               5                  10                  15      
Gly Phe Gly Ala Pro Cys Leu Lys Cys Lys Glu Lys Cys Glu Gly Phe
            20                  25                  30          
Glu Leu His Phe Trp Arg Lys Ile Cys Arg Asn Cys Lys Cys Gly Gln
        35                  40                  45              
Glu Glu His Asp Val Leu Leu Ser Asn Glu Glu Asp Arg Lys Val Gly
    50                  55                  60                  
Lys Leu Phe Glu Asp Thr Lys Tyr Thr Thr Leu Ile Ala Lys Leu Lys
65                  70                  75                  80  
Ser Asp Gly Ile Pro Met Tyr Lys Arg Asn Val Met Ile Leu Thr Asn
                85                  90                  95      
Pro Val Ala Ala Lys Lys Asn Val Ser Ile Asn Thr Val Thr Tyr Glu
            100                 105                 110         
Trp Ala Pro Pro Val Gln Asn Gln Ala Leu Ala Arg Gln Tyr Met Gln
        115                 120                 125             
Met Leu Pro Glu Glu Lys Gln Pro Val Ala Gly Ser Glu Gly Ala Gln
    130                 135                 140                 
Tyr Arg Lys Lys Gln Leu Ala Lys Gln Leu Pro Ala His Asp Gln Asp
145                 150                 155                 160 
Pro Ser Lys Cys His Glu Leu Ser Pro Arg Glu Val Lys Glu Met Glu
                165                 170                 175     
Gln Phe Val Lys Lys Tyr Lys Ser Glu Ala Leu Gly Val Gly Asp Val
            180                 185                 190         
Lys Leu Pro Cys Glu Met Asp Ala Gln Gly Pro Lys Gln Met Asn Ile
        195                 200                 205             
Pro Gly Gly Asp Arg Ser Thr Pro Ala Ala Val Gly Ala Met Glu Asp
    210                 215                 220                 
Lys Ser Ala Glu His Lys Arg Thr Gln Tyr Ser Cys Tyr Cys Cys Lys
225                 230                 235                 240 
Leu Ser Met Lys Glu Gly Asp Pro Ala Ile Tyr Ala Glu Arg Ala Gly
                245                 250                 255     
Tyr Asp Lys Leu Trp His Pro Ala Cys Phe Val Cys Ser Thr Cys His
            260                 265                 270         
Glu Leu Leu Val Asp Met Ile Tyr Phe Trp Lys Asn Glu Lys Leu Tyr
        275                 280                 285             
Cys Gly Arg His Tyr Cys Asp Ser Glu Lys Pro Arg Cys Ala Gly Cys
    290                 295                 300                 
Asp Glu Leu Ile Phe Ser Asn Glu Tyr Thr Gln Ala Glu Asn Gln Asn
305                 310                 315                 320 
Trp His Leu Lys His Phe Cys Cys Phe Asp Cys Asp Ser Ile Leu Ala
                325                 330                 335     
Gly Glu Ile Tyr Val Met Val Asn Asp Lys Pro Val Cys Lys Pro Cys
            340                 345                 350         
Tyr Val Lys Asn His Ala Val Val Cys Gln Gly Cys His Asn Ala Ile
        355                 360                 365             
Asp Pro Glu Val Gln Arg Val Thr Tyr Asn Asn Phe Ser Trp His Ala
    370                 375                 380                 
Ser Thr Glu Cys Phe Leu Cys Ser Cys Cys Ser Lys Cys Leu Ile Gly
385                 390                 395                 400 
Gln Lys Phe Met Pro Val Glu Gly Met Val Phe Cys Ser Val Glu Cys
                405                 410                 415     
Lys Lys Arg Met Ser
            420     


<210> 1033
<211> 345
<212> PRT
<213> Homo sapiens

<400> 1033
Met Asn Leu Glu Gly Thr Asn Leu Asp Lys Leu Pro Met Ala Ser Thr
 1               5                  10                  15      
Ile Thr Lys Ile Pro Ser Pro Leu Ile Thr Glu Glu Gly Pro Asn Leu
            20                  25                  30          
Pro Glu Ile Arg His Arg Gly Arg Phe Ala Val Glu Phe Asn Lys Met
        35                  40                  45              
Gln Asp Leu Val Phe Lys Lys Pro Thr Arg Gln Thr Ile Met Thr Thr
    50                  55                  60                  
Glu Thr Leu Lys Lys Ile Gln Ile Asp Arg Gln Phe Phe Ser Asp Val
65                  70                  75                  80  
Ile Ala Asp Thr Ile Lys Glu Leu Gln Asp Ser Ala Thr Tyr Asn Ser
                85                  90                  95      
Leu Leu Gln Ala Leu Ser Lys Glu Arg Glu Asn Lys Met His Phe Tyr
            100                 105                 110         
Asp Ile Ile Ala Arg Glu Glu Lys Gly Arg Lys Gln Ile Ile Ser Leu
        115                 120                 125             
Gln Lys Gln Leu Ile Asn Val Lys Lys Glu Trp Gln Phe Glu Val Gln
    130                 135                 140                 
Ser Gln Asn Glu Tyr Ile Ala Asn Leu Lys Asp Gln Leu Gln Glu Met
145                 150                 155                 160 
Lys Ala Lys Ser Asn Leu Glu Asn Arg Tyr Met Lys Thr Asn Thr Glu
                165                 170                 175     
Leu Gln Ile Ala Gln Thr Gln Lys Lys Cys Asn Arg Thr Glu Glu Leu
            180                 185                 190         
Leu Val Glu Glu Ile Glu Lys Leu Arg Met Lys Thr Glu Glu Glu Ala
        195                 200                 205             
Arg Thr His Thr Glu Ile Glu Met Phe Leu Arg Lys Glu Gln Gln Lys
    210                 215                 220                 
Leu Glu Glu Arg Leu Glu Phe Trp Met Glu Lys Tyr Asp Lys Asp Thr
225                 230                 235                 240 
Glu Met Lys Gln Asn Glu Leu Asn Ala Leu Lys Ala Thr Lys Ala Ser
                245                 250                 255     
Asp Leu Ala His Leu Gln Asp Leu Ala Lys Met Ile Arg Glu Tyr Glu
            260                 265                 270         
Gln Val Ile Ile Glu Asp Arg Ile Glu Lys Glu Arg Ser Lys Lys Lys
        275                 280                 285             
Val Lys Gln Asp Leu Leu Glu Leu Lys Ser Val Ile Lys Leu Gln Ala
    290                 295                 300                 
Trp Trp Arg Gly Thr Met Ile Arg Arg Glu Ile Gly Gly Phe Lys Met
305                 310                 315                 320 
Pro Lys Asp Lys Val Asp Ser Lys Asp Ser Lys Gly Lys Gly Lys Gly
                325                 330                 335     
Lys Asp Lys Arg Arg Gly Lys Lys Lys
            340                 345 


<210> 1034
<211> 501
<212> PRT
<213> Homo sapiens

<400> 1034
Met Lys Glu Met Ser Ala Asn Thr Val Leu Asp Ser Gln Arg Gln Gln
 1               5                  10                  15      
Lys His Tyr Gly Ile Thr Ser Pro Ile Ser Leu Ala Ser Pro Lys Glu
            20                  25                  30          
Ile Asp His Ile Tyr Thr Gln Lys Leu Ile Asp Ala Met Lys Pro Phe
        35                  40                  45              
Gly Val Phe Glu Asp Glu Glu Glu Leu Asn His Arg Leu Val Val Leu
    50                  55                  60                  
Gly Lys Leu Asn Asn Leu Val Lys Glu Trp Ile Ser Asp Val Ser Glu
65                  70                  75                  80  
Ser Lys Asn Leu Pro Pro Ser Val Val Ala Thr Val Gly Gly Lys Ile
                85                  90                  95      
Phe Thr Phe Gly Ser Tyr Arg Leu Gly Val His Thr Lys Gly Ala Asp
            100                 105                 110         
Ile Asp Ala Leu Cys Val Ala Pro Arg His Val Glu Arg Ser Asp Phe
        115                 120                 125             
Phe Gln Ser Phe Phe Glu Lys Leu Lys His Gln Asp Gly Ile Arg Asn
    130                 135                 140                 
Leu Arg Ala Val Glu Asp Ala Phe Val Pro Val Ile Lys Phe Glu Phe
145                 150                 155                 160 
Asp Gly Ile Glu Ile Asp Leu Val Phe Ala Arg Leu Ala Ile Gln Thr
                165                 170                 175     
Ile Ser Asp Asn Leu Asp Leu Arg Asp Asp Ser Arg Leu Arg Ser Leu
            180                 185                 190         
Asp Ile Arg Cys Ile Arg Ser Leu Asn Gly Cys Arg Val Thr Asp Glu
        195                 200                 205             
Ile Leu His Leu Val Pro Asn Lys Glu Thr Phe Arg Leu Thr Leu Arg
    210                 215                 220                 
Ala Val Lys Leu Trp Ala Lys Arg Arg Gly Ile Tyr Ser Asn Met Leu
225                 230                 235                 240 
Gly Phe Leu Gly Gly Val Ser Trp Ala Met Leu Val Ala Arg Thr Cys
                245                 250                 255     
Gln Leu Tyr Pro Asn Ala Ala Ala Ser Thr Leu Val His Lys Phe Phe
            260                 265                 270         
Leu Val Phe Ser Lys Trp Glu Trp Pro Asn Pro Val Leu Leu Lys Gln
        275                 280                 285             
Pro Glu Glu Ser Asn Leu Asn Leu Pro Val Trp Asp Pro Arg Val Asn
    290                 295                 300                 
Pro Ser Asp Arg Tyr His Leu Met Pro Ile Ile Thr Pro Ala Tyr Pro
305                 310                 315                 320 
Gln Gln Asn Ser Thr Tyr Asn Val Ser Thr Ser Thr Arg Thr Val Met
                325                 330                 335     
Val Glu Glu Phe Lys Gln Gly Leu Ala Val Thr Asp Glu Ile Leu Gln
            340                 345                 350         
Gly Lys Ser Asp Trp Ser Lys Leu Leu Glu Pro Pro Asn Phe Phe Gln
        355                 360                 365             
Lys Tyr Arg His Tyr Ile Val Leu Thr Ala Ser Ala Ser Thr Glu Glu
    370                 375                 380                 
Asn His Leu Glu Trp Val Gly Leu Val Glu Ser Lys Ile Arg Val Leu
385                 390                 395                 400 
Val Gly Asn Leu Glu Arg Asn Glu Phe Ile Thr Leu Ala His Val Asn
                405                 410                 415     
Pro Gln Ser Phe Pro Gly Asn Lys Glu His His Lys Asp Asn Asn Tyr
            420                 425                 430         
Val Ser Met Trp Phe Leu Gly Ile Ile Phe Arg Arg Val Glu Asn Ala
        435                 440                 445             
Glu Ser Val Asn Ile Asp Leu Thr Tyr Asp Ile Gln Ser Phe Thr Asp
    450                 455                 460                 
Thr Val Tyr Arg Gln Ala Asn Asn Ile Asn Met Leu Lys Glu Gly Met
465                 470                 475                 480 
Lys Ile Glu Ala Thr His Val Lys Lys Lys Gln Leu His His Tyr Leu
                485                 490                 495     
Pro Ala Glu Ile Leu
            500     


<210> 1035
<211> 602
<212> PRT
<213> Homo sapiens

<400> 1035
Met Arg Pro Arg Arg Leu Gly Arg Cys Cys Ala Gly Ser Arg Leu Gly
 1               5                  10                  15      
Pro Gly Asp Pro Ala Ala Leu Thr Cys Ala Pro Ser Pro Ser Ala Ser
            20                  25                  30          
Pro Ala Pro Glu Pro Ser Ala Gln Pro Gln Ala Arg Gly Thr Gly Gln
        35                  40                  45              
Arg Val Gly Ser Arg Ala Thr Ser Gly Thr Gln Phe Leu Ser Glu Ala
    50                  55                  60                  
Arg Thr Gly Ala Arg Pro Ala Ser Glu Ala Gly Ala Lys Ala Gly Ala
65                  70                  75                  80  
Arg Arg Pro Ser Ala Phe Ser Ala Ile Gln Gly Asp Val Arg Ser Met
                85                  90                  95      
Pro Asp Asn Ser Asp Ala Pro Trp Thr Arg Phe Val Phe Gln Gly Pro
            100                 105                 110         
Phe Gly Ser Arg Ala Thr Gly Arg Gly Thr Gly Lys Ala Ala Gly Ile
        115                 120                 125             
Trp Lys Thr Pro Ala Ala Tyr Val Gly Arg Arg Pro Gly Val Ser Gly
    130                 135                 140                 
Pro Glu Arg Ala Ala Phe Ile Arg Glu Leu Glu Glu Ala Leu Cys Pro
145                 150                 155                 160 
Asn Leu Pro Pro Pro Val Lys Lys Ile Thr Gln Glu Asp Val Lys Val
                165                 170                 175     
Met Leu Tyr Leu Leu Glu Glu Val Cys Thr Ala Phe Leu Ile Gln Leu
            180                 185                 190         
Leu Pro Pro Val Trp Glu Ser Val Thr Tyr Gly Met Val Leu Gln Arg
        195                 200                 205             
Glu Arg Asp Leu Asn Thr Ala Ala Arg Ile Gly Gln Ser Leu Val Lys
    210                 215                 220                 
Gln Asn Ser Val Leu Met Glu Glu Asn Ser Lys Leu Glu Ala Leu Leu
225                 230                 235                 240 
Gly Ser Ala Lys Glu Glu Ile Leu Tyr Leu Arg His Gln Val Asn Leu
                245                 250                 255     
Arg Asp Glu Leu Leu Gln Leu Tyr Ser Asp Ser Asp Glu Glu Asp Glu
            260                 265                 270         
Asp Glu Glu Glu Glu Glu Glu Glu Lys Glu Ala Glu Glu Glu Gln Glu
        275                 280                 285             
Glu Glu Glu Ala Glu Glu Asp Leu Gln Cys Ala His Pro Cys Asp Ala
    290                 295                 300                 
Pro Lys Leu Ile Ser Gln Glu Ala Leu Leu His Gln His His Cys Pro
305                 310                 315                 320 
Gln Leu Glu Ala Leu Gln Glu Lys Leu Arg Leu Leu Glu Glu Glu Asn
                325                 330                 335     
His Gln Leu Arg Glu Glu Ala Ser Gln Leu Asp Thr Leu Glu Asp Glu
            340                 345                 350         
Glu Gln Met Leu Ile Leu Glu Cys Val Glu Gln Phe Leu Glu Ala Ser
        355                 360                 365             
Gln Gln Met Ala Glu Leu Ser Glu Val Leu Val Leu Arg Leu Glu Asn
    370                 375                 380                 
Tyr Glu Arg Gln Gln Gln Glu Val Ala Arg Leu Gln Ala Gln Val Leu
385                 390                 395                 400 
Lys Leu Gln Gln Arg Cys Arg Met Glu Thr Leu Pro Gly Phe Gln Glu
                405                 410                 415     
Thr Leu Ala Glu Glu Leu Arg Met Ser Leu Arg Arg Met Ile Ser Asp
            420                 425                 430         
Pro Val Tyr Phe Met Glu Arg Asn Tyr Glu Met Pro Arg Gly Asp Thr
        435                 440                 445             
Ser Ser Leu Arg Tyr Asp Phe Arg Tyr Ser Glu Asp Arg Glu Gln Val
    450                 455                 460                 
Arg Gly Phe Glu Ala Glu Glu Gly Leu Met Leu Ala Ala Asp Ile Met
465                 470                 475                 480 
Arg Gly Glu Asp Phe Thr Pro Ala Glu Glu Leu Val Pro Gln Glu Glu
                485                 490                 495     
Leu Gly Ala Ala Lys Lys Val Leu Ala Glu Glu Gly Val Met Glu Glu
            500                 505                 510         
Ala Glu Leu Val Ser Glu Glu Thr Glu Gly Trp Glu Glu Val Glu Leu
        515                 520                 525             
Glu Leu Asp Glu Ala Thr Arg Met Asn Val Val Thr Ser Ala Leu Glu
    530                 535                 540                 
Ala Ser Gly Leu Gly Pro Ser His Leu Asp Met Asn Tyr Val Leu Gln
545                 550                 555                 560 
Gln Leu Ala Asn Trp Gln Asp Ala His Tyr Arg Arg Gln Leu Arg Trp
                565                 570                 575     
Lys Met Leu Gln Lys Gly Glu Cys Pro His Gly Ala Leu Pro Ala Ala
            580                 585                 590         
Ser Arg Thr Ser Cys Arg Ser Ser Cys Arg
        595                 600         


<210> 1036
<211> 409
<212> PRT
<213> Homo sapiens

<400> 1036
Met Glu Glu Gly Gly Ser Thr Gly Ser Ala Gly Ser Asp Ser Ser Thr
 1               5                  10                  15      
Ser Gly Ser Gly Gly Ala Gln Gln Arg Glu Leu Glu Arg Met Ala Glu
            20                  25                  30          
Val Leu Val Thr Gly Glu Gln Leu Arg Leu Arg Leu His Glu Glu Lys
        35                  40                  45              
Val Ile Lys Asp Arg Arg His His Leu Lys Thr Tyr Pro Asn Cys Phe
    50                  55                  60                  
Val Ala Lys Glu Leu Ile Asp Trp Leu Ile Glu His Lys Glu Ala Ser
65                  70                  75                  80  
Asp Arg Glu Thr Ala Ile Lys Leu Met Gln Lys Leu Ala Asp Arg Gly
                85                  90                  95      
Ile Ile His His Val Cys Asp Glu His Lys Glu Phe Lys Asp Val Lys
            100                 105                 110         
Leu Phe Tyr Arg Phe Arg Lys Asp Asp Gly Thr Phe Pro Leu Asp Asn
        115                 120                 125             
Glu Val Lys Ala Phe Met Arg Gly Gln Arg Leu Tyr Glu Lys Leu Met
    130                 135                 140                 
Ser Pro Glu Asn Thr Leu Leu Gln Pro Arg Glu Glu Glu Gly Val Lys
145                 150                 155                 160 
Tyr Glu Arg Thr Phe Val Ala Ser Glu Phe Leu Asp Trp Leu Val Gln
                165                 170                 175     
Glu Gly Glu Ala Thr Thr Arg Lys Glu Ala Glu Gln Leu Cys His Arg
            180                 185                 190         
Leu Met Glu His Gly Ile Ile Gln His Val Ser Ser Lys His Pro Phe
        195                 200                 205             
Val Asp Ser Asn Leu Leu Tyr Gln Phe Arg Met Asn Phe Arg Arg Arg
    210                 215                 220                 
Arg Arg Leu Met Glu Leu Leu Asn Glu Lys Ser Pro Ser Ser Gln Glu
225                 230                 235                 240 
Thr His Asp Ser Pro Phe Cys Leu Arg Lys Gln Ser His Asp Asn Arg
                245                 250                 255     
Lys Ser Thr Ser Phe Met Ser Val Ser Pro Ser Lys Glu Ile Lys Ile
            260                 265                 270         
Val Ser Ala Val Arg Arg Ser Ser Met Ser Ser Cys Gly Ser Ser Gly
        275                 280                 285             
Tyr Phe Ser Ser Ser Pro Thr Leu Ser Ser Ser Pro Pro Val Leu Cys
    290                 295                 300                 
Asn Pro Lys Ser Val Leu Lys Arg Pro Val Thr Ser Glu Glu Leu Leu
305                 310                 315                 320 
Thr Pro Gly Ala Pro Tyr Ala Arg Lys Thr Phe Thr Ile Val Gly Asp
                325                 330                 335     
Ala Val Gly Trp Gly Phe Val Val Arg Gly Ser Lys Pro Cys His Ile
            340                 345                 350         
Gln Ala Val Asp Pro Ser Gly Pro Ala Ala Ala Ala Gly Met Lys Val
        355                 360                 365             
Cys Gln Phe Val Val Ser Val Asn Gly Leu Asn Val Leu His Val Asp
    370                 375                 380                 
Tyr Arg Thr Val Asn Asn Leu Ile Leu Thr Gly Pro Arg Thr Ile Val
385                 390                 395                 400 
Met Glu Val Met Glu Glu Leu Glu Cys
                405                 


<210> 1037
<211> 486
<212> PRT
<213> Homo sapiens

<400> 1037
Met Arg Arg Leu Val His Asp Leu Leu Pro Pro Glu Val Cys Ser Leu
 1               5                  10                  15      
Leu Asn Pro Ala Ala Ile Tyr Ala Asp Asn Glu Ile Ser Leu Arg Asp
            20                  25                  30          
Val Glu Val Tyr Gly Phe Asp Tyr Asp Tyr Thr Leu Ala Gln Tyr Ala
        35                  40                  45              
Asp Ala Leu His Pro Glu Ile Phe Ser Thr Ala Arg Asp Ile Leu Ile
    50                  55                  60                  
Glu His Tyr Lys Tyr Pro Glu Gly Ile Arg Lys Tyr Asp Tyr Asn Pro
65                  70                  75                  80  
Ser Phe Ala Ile Arg Gly Leu His Tyr Asp Ile Gln Lys Ser Leu Leu
                85                  90                  95      
Met Lys Ile Asp Ala Phe His Tyr Val Gln Leu Gly Thr Ala Tyr Arg
            100                 105                 110         
Gly Leu Gln Pro Val Pro Asp Glu Glu Val Ile Glu Leu Tyr Gly Gly
        115                 120                 125             
Thr Gln His Ile Pro Leu Tyr Gln Met Ser Gly Phe Tyr Gly Lys Gly
    130                 135                 140                 
Pro Ser Ile Lys Gln Phe Met Asp Ile Phe Ser Leu Pro Glu Met Ala
145                 150                 155                 160 
Leu Leu Ser Cys Val Val Asp Tyr Phe Leu Gly His Ser Leu Glu Phe
                165                 170                 175     
Asp Gln Ala His Leu Tyr Lys Asp Val Thr Asp Ala Ile Arg Asp Val
            180                 185                 190         
His Val Lys Gly Leu Met Tyr Gln Trp Ile Glu Gln Asp Met Glu Lys
        195                 200                 205             
Tyr Ile Leu Arg Gly Asp Glu Thr Phe Ala Val Leu Ser Arg Leu Val
    210                 215                 220                 
Ala His Gly Lys Gln Leu Phe Leu Ile Thr Asn Ser Pro Phe Ser Phe
225                 230                 235                 240 
Val Asp Lys Gly Met Arg His Met Val Gly Pro Asp Trp Arg Gln Leu
                245                 250                 255     
Phe Asp Val Val Ile Val Gln Ala Asp Lys Pro Ser Phe Phe Thr Asp
            260                 265                 270         
Arg Arg Lys Pro Phe Arg Lys Leu Asp Glu Lys Gly Ser Leu Gln Trp
        275                 280                 285             
Asp Arg Ile Thr Arg Leu Glu Lys Gly Lys Ile Tyr Arg Gln Gly Asn
    290                 295                 300                 
Leu Phe Asp Phe Leu Arg Leu Thr Glu Trp Arg Gly Pro Arg Val Leu
305                 310                 315                 320 
Tyr Phe Gly Asp His Leu Tyr Ser Asp Leu Ala Asp Leu Met Leu Arg
                325                 330                 335     
His Gly Trp Arg Thr Gly Ala Ile Ile Pro Glu Leu Glu Arg Glu Ile
            340                 345                 350         
Arg Ile Ile Asn Thr Glu Gln Tyr Met His Ser Leu Thr Trp Gln Gln
        355                 360                 365             
Ala Leu Thr Gly Leu Leu Glu Arg Met Gln Thr Tyr Gln Asp Ala Glu
    370                 375                 380                 
Ser Arg Gln Val Leu Ala Ala Trp Met Lys Glu Arg Gln Glu Leu Arg
385                 390                 395                 400 
Cys Ile Thr Lys Ala Leu Phe Asn Ala Gln Phe Gly Ser Ile Phe Arg
                405                 410                 415     
Thr Phe His Asn Pro Thr Tyr Phe Ser Arg Arg Leu Val Arg Phe Ser
            420                 425                 430         
Asp Leu Tyr Met Ala Ser Leu Ser Arg Leu Leu Asn Tyr Arg Val Asp
        435                 440                 445             
Phe Thr Phe Tyr Pro Arg Arg Thr Ser Leu Gln His Glu Ala Pro Leu
    450                 455                 460                 
Trp Met Asp Gln Leu Cys Thr Gly Cys Met Lys Thr Pro Phe Leu Gly
465                 470                 475                 480 
Asp Met Ala His Ile Arg
                485     


<210> 1038
<211> 806
<212> PRT
<213> Homo sapiens

<400> 1038
Met Tyr Glu His Leu Phe Pro Glu Leu Val Asp Asp Phe Gln Asp Tyr
 1               5                  10                  15      
Asp Leu Ile Ser Lys Glu Pro Lys Pro Phe Val Phe Glu Gly Lys Val
            20                  25                  30          
Arg Gly Pro Ile Val Val Pro Thr Ala Gly Glu Glu Thr Ser Gly Asn
        35                  40                  45              
Ser Gly Asn Leu Arg Lys Val Val Met Lys Glu Asn Ile Ser Ser Lys
    50                  55                  60                  
Gly Asp Glu Gly Glu Lys Lys Ser Thr Phe Met Asp Leu Ala Lys Glu
65                  70                  75                  80  
Asp Ile Lys Asp Asn Asp Arg Thr Leu Gln Gln Gln Pro Gly Asp Gln
                85                  90                  95      
Asn Arg Thr Ile Ser Ser Val His Gly Leu Asn Asn Asp Ile Val Lys
            100                 105                 110         
Ala Leu Asp Arg Ile Thr Leu Gln Asn Ile Pro Ser Gln Thr Ala Pro
        115                 120                 125             
Gly Phe Thr Ala Glu Met Lys Lys Asp Cys Ser Leu Pro Leu Thr Val
    130                 135                 140                 
Leu Thr Cys Ala Lys Ala Cys Pro His Val Ala Thr Cys Gly Asn Val
145                 150                 155                 160 
Leu Phe Glu Gly Arg Thr Val Gln Leu Gly Lys Leu Cys Cys Thr Gly
                165                 170                 175     
Val Glu Thr Glu Asp Asp Glu Asp Thr Glu Ser Asn Ser Ser Val Glu
            180                 185                 190         
Gln Ala Ser Val Glu Val Pro Asp Gly Pro Thr Leu His Asp Pro Asp
        195                 200                 205             
Leu Tyr Ile Glu Ile Val Lys Asn Thr Lys Ser Val Pro Glu Tyr Ser
    210                 215                 220                 
Glu Val Ala Tyr Pro Asp Tyr Phe Gly His Ile Pro Pro Pro Phe Lys
225                 230                 235                 240 
Glu Pro Ile Leu Glu Arg Pro Tyr Gly Val Gln Arg Thr Lys Ile Ala
                245                 250                 255     
Gln Asp Ile Glu Arg Leu Ile His Gln Ser Asp Ile Ile Asp Arg Val
            260                 265                 270         
Val Tyr Asp Leu Asp Asn Pro Asn Tyr Thr Ile Pro Glu Glu Gly Asp
        275                 280                 285             
Ile Leu Lys Phe Asn Ser Lys Phe Glu Ser Gly Asn Leu Arg Lys Val
    290                 295                 300                 
Ile Gln Ile Arg Lys Asn Glu Tyr Asp Leu Ile Leu Asn Ser Asp Ile
305                 310                 315                 320 
Asn Ser Asn His Tyr His Gln Trp Phe Tyr Phe Glu Val Ser Gly Thr
                325                 330                 335     
Arg Pro Gly Val Ala Tyr Arg Phe Asn Ile Ile Asn Cys Glu Lys Ser
            340                 345                 350         
Asn Ser Gln Phe Asn Tyr Gly Met Gln Pro Leu Met Tyr Ser Val Gln
        355                 360                 365             
Glu Ala Leu Asn Ala Arg Pro Trp Trp Ile Arg Met Gly Thr Asp Ile
    370                 375                 380                 
Cys Tyr Tyr Lys Asn His Phe Ser Arg Ser Ser Val Ala Ala Gly Gly
385                 390                 395                 400 
Gln Lys Gly Lys Ser Tyr Tyr Thr Ile Thr Phe Thr Val Asn Phe Pro
                405                 410                 415     
His Lys Asp Asp Val Cys Tyr Phe Ala Tyr His Tyr Pro Tyr Thr Tyr
            420                 425                 430         
Ser Thr Leu Gln Met His Leu Gln Lys Leu Glu Ser Ala His Asn Pro
        435                 440                 445             
Gln Gln Ile Tyr Phe Arg Lys Asp Val Leu Cys Glu Thr Leu Ser Gly
    450                 455                 460                 
Asn Ser Cys Pro Leu Val Thr Ile Thr Ala Met Pro Glu Ser Asn Tyr
465                 470                 475                 480 
Tyr Glu His Ile Cys His Phe Arg Asn Arg Pro Tyr Val Phe Leu Ser
                485                 490                 495     
Ala Arg Val His Pro Gly Glu Thr Asn Ala Ser Trp Val Met Lys Gly
            500                 505                 510         
Thr Leu Glu Tyr Leu Met Ser Asn Asn Pro Thr Ala Gln Ser Leu Arg
        515                 520                 525             
Glu Ser Tyr Ile Phe Lys Ile Val Pro Met Leu Asn Pro Asp Gly Val
    530                 535                 540                 
Ile Asn Gly Asn His Arg Cys Ser Leu Ser Gly Glu Asp Leu Asn Arg
545                 550                 555                 560 
Gln Trp Gln Ser Pro Ser Pro Asp Leu His Pro Thr Ile Tyr His Ala
                565                 570                 575     
Lys Gly Leu Leu Gln Tyr Leu Ala Ala Val Lys Arg Leu Pro Leu Val
            580                 585                 590         
Tyr Cys Asp Tyr His Gly His Ser Arg Lys Lys Asn Val Phe Met Tyr
        595                 600                 605             
Gly Cys Ser Ile Lys Glu Thr Val Trp His Thr Asn Asp Asn Ala Thr
    610                 615                 620                 
Ser Cys Asp Val Val Glu Asp Thr Gly Tyr Arg Thr Leu Pro Lys Ile
625                 630                 635                 640 
Leu Ser His Ile Ala Pro Ala Phe Cys Met Ser Ser Cys Ser Phe Val
                645                 650                 655     
Val Glu Lys Ser Lys Glu Ser Thr Ala Arg Val Val Val Trp Arg Glu
            660                 665                 670         
Ile Gly Val Gln Arg Ser Tyr Thr Met Glu Ser Thr Leu Cys Gly Cys
        675                 680                 685             
Asp Gln Gly Lys Tyr Lys Gly Leu Gln Ile Gly Thr Arg Glu Leu Glu
    690                 695                 700                 
Glu Met Gly Ala Lys Phe Cys Val Gly Leu Leu Arg Leu Lys Arg Leu
705                 710                 715                 720 
Thr Ser Pro Leu Glu Tyr Asn Leu Pro Ser Ser Leu Leu Asp Phe Glu
                725                 730                 735     
Asn Asp Leu Ile Glu Ser Ser Cys Lys Val Thr Ser Pro Thr Thr Tyr
            740                 745                 750         
Val Leu Asp Glu Asp Glu Pro Arg Phe Leu Glu Glu Val Asp Tyr Ser
        755                 760                 765             
Ala Glu Ser Asn Asp Glu Leu Asp Ile Glu Leu Ala Glu Asn Val Gly
    770                 775                 780                 
Asp Tyr Glu Pro Ser Ala Gln Glu Glu Val Leu Ser Asp Ser Glu Leu
785                 790                 795                 800 
Ser Arg Thr Tyr Leu Pro
                805     


<210> 1039
<211> 730
<212> PRT
<213> Homo sapiens

<400> 1039
Met Gly Leu Gly Lys Thr Ile Gln Ser Ile Thr Phe Leu Tyr Glu Ile
 1               5                  10                  15      
Leu Leu Thr Gly Ile Arg Gly Pro Phe Leu Ile Ile Ala Pro Leu Ser
            20                  25                  30          
Thr Ile Ala Asn Trp Glu Arg Glu Phe Arg Thr Trp Thr Asp Ile Asn
        35                  40                  45              
Val Val Val Tyr His Gly Ser Leu Ile Ser Arg Gln Met Ile Gln Gln
    50                  55                  60                  
Tyr Glu Met Tyr Phe Arg Asp Ser Gln Gly Arg Ile Ile Arg Gly Ala
65                  70                  75                  80  
Tyr Arg Phe Gln Ala Ile Ile Thr Thr Phe Glu Met Ile Leu Gly Gly
                85                  90                  95      
Cys Gly Glu Leu Asn Ala Ile Glu Trp Arg Cys Val Ile Ile Asp Glu
            100                 105                 110         
Ala His Arg Leu Lys Asn Lys Asn Cys Lys Leu Leu Glu Gly Leu Lys
        115                 120                 125             
Leu Met Asn Leu Glu His Lys Val Leu Leu Thr Gly Thr Pro Leu Gln
    130                 135                 140                 
Asn Thr Val Glu Glu Leu Phe Ser Leu Leu His Phe Leu Glu Pro Leu
145                 150                 155                 160 
Arg Phe Pro Ser Glu Ser Thr Phe Met Gln Glu Phe Gly Asp Leu Lys
                165                 170                 175     
Thr Glu Glu Gln Val Gln Lys Leu Gln Val Ile Leu Lys Pro Met Met
            180                 185                 190         
Leu Arg Arg Leu Lys Glu Asp Val Glu Lys Lys Leu Ala Pro Lys Glu
        195                 200                 205             
Glu Thr Ile Ile Glu Val Glu Leu Thr Asn Ile Gln Lys Lys Tyr Tyr
    210                 215                 220                 
Arg Ala Ile Leu Glu Lys Asn Phe Ser Phe Leu Ser Lys Gly Ala Gly
225                 230                 235                 240 
Gln Thr Asn Val Pro Asn Leu Val Asn Thr Met Met Glu Leu Arg Lys
                245                 250                 255     
Cys Cys Asn His Pro Tyr Leu Ile Lys Gly Ala Glu Glu Lys Ile Leu
            260                 265                 270         
Gly Glu Phe Arg Asp Thr Tyr Asn Pro Ala Ala Ser Asp Phe His Leu
        275                 280                 285             
Gln Ala Met Ile Gln Ser Ala Gly Lys Leu Val Leu Ile Asp Lys Leu
    290                 295                 300                 
Leu Pro Lys Met Lys Ala Gly Gly His Lys Val Leu Ile Phe Ser Gln
305                 310                 315                 320 
Met Val Arg Cys Leu Asp Ile Leu Glu Asp Tyr Leu Ile His Lys Arg
                325                 330                 335     
Tyr Leu Tyr Glu Arg Ile Asp Gly Arg Val Arg Gly Asn Leu Arg Gln
            340                 345                 350         
Ala Ala Ile Asp Arg Phe Ser Lys Pro Asp Ser Asp Arg Phe Val Phe
        355                 360                 365             
Leu Leu Cys Thr Arg Ala Gly Gly Leu Gly Ile Asn Leu Thr Ala Ala
    370                 375                 380                 
Asp Thr Cys Ile Ile Phe Asp Ser Asp Trp Asn Pro Gln Asn Asp Leu
385                 390                 395                 400 
Gln Ala Gln Ala Arg Cys His Arg Ile Gly Gln Asn Lys Ala Val Lys
                405                 410                 415     
Val Tyr Arg Leu Val Thr Arg Asn Ser Tyr Glu Arg Glu Met Phe Asp
            420                 425                 430         
Arg Ala Ser Leu Lys Leu Gly Leu Asp Lys Ala Val Leu Gln Ser Met
        435                 440                 445             
Ser Gly Arg Glu Ser Asn Val Gly Gly Ile Gln Gln Leu Ser Lys Lys
    450                 455                 460                 
Glu Ile Glu Asp Leu Leu Arg Arg Gly Ala Tyr Gly Ala Ile Met Glu
465                 470                 475                 480 
Glu Glu Asp Glu Gly Ser Lys Phe Cys Glu Glu Asp Ile Asp Gln Ile
                485                 490                 495     
Leu Leu Arg Arg Thr Lys Thr Ile Thr Ile Glu Ser Glu Gly Arg Gly
            500                 505                 510         
Ser Thr Phe Ala Lys Ala Ser Phe Val Ala Ser Gly Asn Arg Thr Asp
        515                 520                 525             
Ile Ser Leu Asp Asp Pro Asn Phe Trp Gln Lys Trp Ala Lys Lys Ala
    530                 535                 540                 
Glu Ile Asp Ile Glu Ala Ile Ser Gly Arg Asn Gly Leu Val Ile Asp
545                 550                 555                 560 
Thr Pro Arg Ile Arg Lys Gln Thr Arg Pro Phe Ser Ala Thr Lys Asp
                565                 570                 575     
Glu Leu Ala Glu Leu Ser Glu Ala Glu Ser Glu Gly Asp Glu Lys Pro
            580                 585                 590         
Lys Leu Arg Arg Pro Cys Asp Arg Ser Asn Gly Tyr Gly Arg Thr Glu
        595                 600                 605             
Cys Phe Arg Val Glu Lys Asn Leu Leu Val Tyr Gly Trp Gly Arg Trp
    610                 615                 620                 
Arg Glu Ile Leu Ser His Gly Arg Phe Lys Arg Gln Leu Asn Glu His
625                 630                 635                 640 
Asp Val Glu Ile Ile Cys Arg Ala Leu Leu Ala Tyr Cys Leu Val His
                645                 650                 655     
Tyr Arg Gly Asp Glu Lys Ile Lys Gly Phe Ile Trp Asp Leu Ile Thr
            660                 665                 670         
Pro Thr Glu Asp Gly Gln Thr Arg Glu Leu Gln Asn His Leu Gly Leu
        675                 680                 685             
Ser Ala Pro Val Pro Arg Gly Arg Lys Gly Lys Lys Val Lys Thr Gln
    690                 695                 700                 
Thr Ser Ser Phe Asp Ile Gln Lys Ala Glu Trp Leu Arg Lys Tyr Asn
705                 710                 715                 720 
Pro Glu Gln Leu Leu Gln Asp Glu Gly Tyr
                725                 730 


<210> 1040
<211> 664
<212> PRT
<213> Homo sapiens

<400> 1040
Met Gln Leu Ile Ser Ile Ala Pro Glu Asn Leu Gln His Asp Ile Ile
 1               5                  10                  15      
Thr Ser Leu Pro Glu Ile Leu Gly Asp Ser Gln His Ala Asp Val Gly
            20                  25                  30          
Lys Glu Leu Ser Asp Leu Leu Ile Glu Asn Thr Ser Leu Thr Val Pro
        35                  40                  45              
Ile Leu Asp Val Leu Ser Ser Leu Arg Leu Asp Pro Asp Phe Leu Leu
    50                  55                  60                  
Lys Val Arg Gln Leu Val Met Asp Lys Leu Ser Ser Ile Arg Leu Glu
65                  70                  75                  80  
Asp Leu Pro Val Ile Ile Lys Phe Ile Leu His Ser Val Thr Ala Met
                85                  90                  95      
Asp Thr Leu Glu Val Ile Ser Glu Leu Arg Glu Lys Leu Asp Leu Gln
            100                 105                 110         
His Cys Val Leu Pro Ser Arg Leu Gln Ala Ser Gln Val Lys Leu Lys
        115                 120                 125             
Ser Lys Gly Arg Ala Ser Ser Ser Gly Asn Gln Glu Ser Ser Gly Gln
    130                 135                 140                 
Ser Cys Ile Ile Leu Leu Phe Asp Val Ile Lys Ser Ala Ile Arg Tyr
145                 150                 155                 160 
Glu Lys Thr Ile Ser Glu Ala Trp Ile Lys Ala Ile Glu Asn Thr Ala
                165                 170                 175     
Ser Val Ser Glu His Lys Val Phe Asp Leu Val Met Leu Phe Ile Ile
            180                 185                 190         
Tyr Ser Thr Asn Thr Gln Thr Lys Lys Tyr Ile Asp Arg Val Leu Arg
        195                 200                 205             
Asn Lys Ile Arg Ser Gly Cys Ile Gln Glu Gln Leu Leu Gln Ser Thr
    210                 215                 220                 
Phe Ser Val His Tyr Leu Val Leu Lys Asp Met Cys Ser Ser Ile Leu
225                 230                 235                 240 
Ser Leu Ala Gln Ser Leu Leu His Ser Leu Asp Gln Ser Ile Ile Ser
                245                 250                 255     
Phe Gly Ser Leu Leu Tyr Lys Tyr Ala Phe Lys Phe Phe Asp Thr Tyr
            260                 265                 270         
Cys Gln Gln Glu Val Val Gly Ala Leu Val Thr His Ile Cys Ser Gly
        275                 280                 285             
Asn Glu Ala Glu Val Asp Thr Ala Leu Asp Val Leu Leu Glu Leu Val
    290                 295                 300                 
Val Leu Asn Pro Ser Ala Met Met Met Asn Ala Val Phe Val Lys Gly
305                 310                 315                 320 
Ile Leu Asp Tyr Leu Asp Asn Ile Ser Pro Gln Gln Ile Arg Lys Leu
                325                 330                 335     
Phe Tyr Val Leu Ser Thr Leu Ala Phe Ser Lys Gln Asn Glu Ala Ser
            340                 345                 350         
Ser His Ile Gln Asp Asp Met His Ser Val Ile Arg Lys Gln Leu Ser
        355                 360                 365             
Ser Thr Val Phe Lys Tyr Lys Leu Ile Gly Ile Ile Gly Ala Val Thr
    370                 375                 380                 
Met Ala Gly Ile Met Ala Ala Asp Gly Ser Glu Ser Pro Ser Leu Thr
385                 390                 395                 400 
Gln Glu Arg Ala Asn Leu Ser Asp Glu Gln Cys Thr Gln Val Thr Ser
                405                 410                 415     
Leu Leu Gln Leu Val His Ser Cys Ser Glu Gln Ser Pro Gln Ala Ser
            420                 425                 430         
Ala Leu Tyr Tyr Asp Glu Phe Ala Asn Leu Ile Gln His Glu Lys Leu
        435                 440                 445             
Asp Pro Lys Ala Leu Glu Trp Val Gly His Thr Ile Cys Asn Asp Phe
    450                 455                 460                 
Gln Asp Ala Phe Val Val Asp Ser Cys Val Val Pro Glu Gly Asp Phe
465                 470                 475                 480 
Pro Phe Pro Val Lys Ala Leu Tyr Gly Leu Glu Glu Tyr Asp Thr Gln
                485                 490                 495     
Asp Gly Ile Ala Ile Asn Leu Leu Pro Leu Leu Phe Ser Gln Asp Phe
            500                 505                 510         
Ala Lys Asp Gly Gly Pro Val Thr Ser Gln Glu Ser Gly Gln Lys Leu
        515                 520                 525             
Val Ser Pro Leu Cys Leu Ala Pro Tyr Phe Arg Leu Leu Arg Leu Cys
    530                 535                 540                 
Val Glu Arg Gln His Asn Gly Asn Leu Glu Glu Ile Asp Gly Leu Leu
545                 550                 555                 560 
Asp Cys Pro Ile Phe Leu Thr Asp Leu Glu Pro Gly Glu Lys Leu Glu
                565                 570                 575     
Ser Met Ser Ala Lys Glu Arg Ser Phe Met Cys Ser Leu Ile Phe Leu
            580                 585                 590         
Thr Leu Asn Trp Phe Arg Glu Ile Val Asn Ala Phe Cys Gln Glu Thr
        595                 600                 605             
Ser Pro Glu Met Lys Gly Lys Val Leu Thr Arg Leu Lys His Ile Val
    610                 615                 620                 
Glu Leu Gln Ile Ile Leu Glu Lys Tyr Leu Ala Val Thr Pro Asp Tyr
625                 630                 635                 640 
Val Pro Pro Leu Gly Asn Phe Asp Val Glu Thr Leu Asp Ile Thr Pro
                645                 650                 655     
His Thr Val Thr Ala Ile Ser Ala
            660                 


<210> 1041
<211> 705
<212> PRT
<213> Homo sapiens

<400> 1041
Met Asp Arg Gln Ser Val Leu His Val Leu Gly Ile Leu Lys Asn Ser
 1               5                  10                  15      
Lys Phe Leu Lys Val Cys Leu Pro Ala Tyr Val Val Gly Met Ile Thr
            20                  25                  30          
Glu Pro Ile Pro Asp Ile Arg Asn Gln Tyr Pro Glu His Ile Ser Asn
        35                  40                  45              
Ile Ile Ser Leu Leu Gln Asp Leu Val Ser Val Phe Pro Ala Ser Ser
    50                  55                  60                  
Val Gln Glu Thr Ser Met Leu Val Ser Leu Leu Pro Thr Ser Leu Asn
65                  70                  75                  80  
Ala Leu Arg Ala Ser Gly Val Asp Ile Glu Glu Glu Thr Glu Lys Asn
                85                  90                  95      
Leu Glu Lys Val Gln Thr Ile Ile Glu His Leu Gln Glu Lys Arg Arg
            100                 105                 110         
Glu Gly Thr Leu Arg Val Asp Thr Tyr Thr Leu Val Gln Pro Glu Ala
        115                 120                 125             
Glu Asp His Val Glu Ser Tyr Arg Thr Met Pro Ile Tyr Pro Thr Tyr
    130                 135                 140                 
Asn Glu Val His Leu Asp Glu Arg Pro Phe Leu Arg Pro Asn Ile Ile
145                 150                 155                 160 
Ser Gly Lys Tyr Asp Ser Thr Ala Ile Tyr Leu Asp Thr His Phe Arg
                165                 170                 175     
Leu Leu Arg Glu Asp Phe Val Arg Pro Leu Arg Glu Gly Ile Leu Glu
            180                 185                 190         
Leu Leu Gln Ser Phe Glu Asp Gln Gly Leu Arg Lys Arg Lys Phe Asp
        195                 200                 205             
Asp Ile Arg Ile Tyr Phe Asp Thr Arg Ile Ile Thr Pro Met Cys Ser
    210                 215                 220                 
Ser Ser Gly Ile Val Tyr Lys Val Gln Phe Asp Thr Lys Pro Leu Lys
225                 230                 235                 240 
Phe Val Arg Trp Gln Asn Ser Lys Arg Leu Leu Tyr Gly Ser Leu Val
                245                 250                 255     
Cys Met Ser Lys Asp Asn Phe Glu Thr Phe Leu Phe Ala Thr Val Ser
            260                 265                 270         
Asn Arg Glu Gln Glu Asp Leu Cys Arg Gly Ile Val Gln Leu Cys Phe
        275                 280                 285             
Asn Glu Gln Ser Gln Gln Leu Leu Ala Glu Val Gln Pro Ser Asp Ser
    290                 295                 300                 
Phe Leu Met Val Glu Thr Thr Ala Tyr Phe Glu Ala Tyr Arg His Val
305                 310                 315                 320 
Leu Glu Gly Leu Gln Glu Val Gln Glu Glu Asp Val Pro Phe Gln Arg
                325                 330                 335     
Asn Ile Val Glu Cys Asn Ser His Val Lys Glu Pro Arg Tyr Leu Leu
            340                 345                 350         
Met Gly Gly Arg Tyr Asp Phe Thr Pro Leu Ile Glu Asn Pro Ser Ala
        355                 360                 365             
Thr Gly Glu Phe Leu Arg Asn Val Glu Gly Leu Arg His Pro Arg Ile
    370                 375                 380                 
Asn Val Leu Asp Pro Gly Gln Trp Pro Ser Lys Glu Ala Leu Lys Leu
385                 390                 395                 400 
Asp Asp Ser Gln Met Glu Ala Leu Gln Phe Ala Leu Thr Arg Glu Leu
                405                 410                 415     
Ala Ile Ile Gln Gly Pro Pro Gly Thr Gly Lys Thr Tyr Val Gly Leu
            420                 425                 430         
Lys Ile Val Gln Ala Leu Leu Thr Asn Glu Ser Val Trp Gln Ile Ser
        435                 440                 445             
Leu Gln Lys Phe Pro Ile Leu Val Val Cys Tyr Thr Asn His Ala Leu
    450                 455                 460                 
Asp Gln Phe Leu Glu Gly Ile Tyr Asn Cys Gln Lys Thr Ser Ile Val
465                 470                 475                 480 
Arg Val Gly Gly Arg Ser Asn Ser Glu Ile Leu Lys Gln Phe Thr Leu
                485                 490                 495     
Arg Glu Leu Arg Asn Lys Arg Glu Phe Arg Arg Asn Leu Pro Met His
            500                 505                 510         
Leu Arg Arg Ala Tyr Met Ser Ile Met Thr Gln Met Lys Glu Ser Glu
        515                 520                 525             
Gln Glu Leu His Glu Gly Ala Lys Thr Leu Glu Cys Thr Met Arg Gly
    530                 535                 540                 
Val Leu Arg Glu Gln Tyr Leu Gln Lys Tyr Ile Ser Pro Gln His Trp
545                 550                 555                 560 
Glu Ser Leu Met Asn Gly Pro Val Gln Asp Ser Glu Trp Ile Cys Phe
                565                 570                 575     
Gln His Trp Lys His Ser Met Met Leu Glu Trp Leu Gly Leu Gly Val
            580                 585                 590         
Gly Ser Phe Thr Gln Ser Val Ser Pro Ala Gly Pro Glu Asn Thr Ala
        595                 600                 605             
Gln Ala Glu Gly Asp Glu Glu Glu Glu Gly Glu Glu Glu Ser Ser Leu
    610                 615                 620                 
Ile Glu Ile Ala Glu Glu Ala Asp Leu Ile Gln Ala Asp Arg Val Ile
625                 630                 635                 640 
Glu Glu Glu Glu Val Val Arg Pro Gln Arg Arg Lys Lys Glu Glu Ser
                645                 650                 655     
Gly Ala Asp Gln Glu Leu Ala Lys Met Leu Leu Ala Met Arg Leu Asp
            660                 665                 670         
His Cys Gly Thr Gly Thr Ala Ala Gly Gln Glu Gln Ala Thr Gly Glu
        675                 680                 685             
Trp Gln Thr Val Pro Cys Leu Val Leu Met Ser Ala Asp Pro Ala Gln
    690                 695                 700                 
Pro
705 


<210> 1042
<211> 213
<212> PRT
<213> Homo sapiens

<400> 1042
Met Ala Leu Leu Val Arg Val Leu Arg Asn Gln Thr Ser Ile Ser Gln
 1               5                  10                  15      
Trp Val Pro Val Cys Ser Arg Leu Ile Pro Val Ser Pro Thr Gln Gly
            20                  25                  30          
Gln Gly Asp Arg Ala Leu Ser Arg Thr Ser Gln Trp Pro Gln Met Ser
        35                  40                  45              
Gln Ser Gln Ala Cys Gly Gly Ser Glu Gln Ile Pro Gly Ile Asp Ile
    50                  55                  60                  
Gln Leu Asn Arg Lys Tyr His Thr Thr Arg Lys Leu Ser Thr Thr Lys
65                  70                  75                  80  
Asp Ser Pro Gln Pro Val Glu Glu Lys Val Gly Ala Phe Thr Lys Ile
                85                  90                  95      
Ile Glu Ala Met Gly Phe Thr Gly Pro Leu Lys Tyr Ser Lys Trp Lys
            100                 105                 110         
Ile Lys Ile Ala Ala Leu Arg Met Tyr Thr Ser Cys Val Glu Lys Thr
        115                 120                 125             
Asp Phe Glu Glu Phe Phe Leu Arg Cys Gln Met Pro Asp Thr Phe Asn
    130                 135                 140                 
Ser Trp Phe Leu Ile Thr Leu Leu His Val Trp Met Cys Leu Val Arg
145                 150                 155                 160 
Met Lys Gln Glu Gly Arg Ser Gly Lys Tyr Met Cys Arg Ile Ile Val
                165                 170                 175     
His Phe Met Trp Glu Asp Val Gln Gln Arg Gly Arg Val Met Gly Gly
            180                 185                 190         
Ile Leu Ser Asp Asp His Gly Leu Ala Ala Ala Leu Trp Arg Thr Phe
        195                 200                 205             
Phe Asn Arg Lys Cys
    210             


<210> 1043
<211> 236
<212> PRT
<213> Homo sapiens

<400> 1043
Met Lys Asp Gln His Leu Arg Gly Phe Phe Ser Asp Ser Thr Ser Phe
 1               5                  10                  15      
Asn Ile Leu Met Asp Met Leu Phe Ile Lys Gly Lys Tyr Lys Ser Ala
            20                  25                  30          
Leu Gln Val Leu Ile Glu Met Lys Asn Leu Asp Val Lys Phe Thr Lys
        35                  40                  45              
Asp Thr Tyr Val Leu Ala Phe Ala Ile Cys Tyr Lys Leu Asn Ser Pro
    50                  55                  60                  
Glu Ser Phe Lys Ile Cys Thr Thr Leu Arg Glu Glu Ala Leu Leu Lys
65                  70                  75                  80  
Gly Glu Ile Leu Ser Arg Arg Ala Ser Cys Phe Ala Val Ala Leu Ala
                85                  90                  95      
Leu Asn Gln Asn Glu Met Ala Lys Ala Val Ser Ile Phe Ser Gln Ile
            100                 105                 110         
Met Asn Pro Glu Ser Ile Ala Cys Ile Asn Leu Asn Ile Ile Ile His
        115                 120                 125             
Ile Gln Ser Asn Met Leu Glu Asn Leu Ile Lys Thr Leu Lys Asn Ala
    130                 135                 140                 
Ala Glu Gly Asn Leu Ser Lys Phe Val Lys Arg His Val Phe Ser Glu
145                 150                 155                 160 
Glu Val Leu Ala Lys Val Arg Glu Lys Val Lys Asp Val Pro Ala Leu
                165                 170                 175     
Val Ala Lys Phe Asp Glu Ile Tyr Gly Thr Leu His Ile Thr Gly Gln
            180                 185                 190         
Val Thr Thr Asp Ser Leu Asp Ala Val Leu Cys His Thr Pro Arg Asp
        195                 200                 205             
Arg Lys Ser His Thr Leu Leu Leu Asn Lys Arg Met Val Ser Arg Arg
    210                 215                 220                 
Thr Phe Gln Pro Leu Ser Gln Ser Leu Leu Ala Glu
225                 230                 235     


<210> 1044
<211> 938
<212> PRT
<213> Homo sapiens

<400> 1044
Met His Arg Tyr Leu Pro Arg Leu His Leu Val Pro Ala Glu Lys Ala
 1               5                  10                  15      
Val Glu Val Ile Gln Leu Asn Gly Pro Gly Val His Thr Phe Thr Phe
            20                  25                  30          
Pro Gln Thr Glu Phe Phe Ala Val Thr Ala Tyr Gln Asn Ile Gln Ile
        35                  40                  45              
Thr Gln Leu Lys Ile Asp Tyr Asn Pro Phe Ala Lys Gly Phe Arg Asp
    50                  55                  60                  
Asp Gly Leu Asn Asn Asn Pro Gln Arg Asp Gly Lys Gln Lys Asn Ser
65                  70                  75                  80  
Ser Asp Gln Glu Gly Asn Asn Ile Ser Ser Ser Ser Gly His Arg Val
                85                  90                  95      
Arg Leu Thr Glu Gly Gln Gly Ser Glu Ile Gln Pro Gly Asp Leu Asp
            100                 105                 110         
Pro Leu Ser Arg Gly His Glu Thr Ser Gly Lys Gly Leu Glu Lys Thr
        115                 120                 125             
Ser Leu Asn Ile Lys Arg Asp Phe Leu Gly Phe Met Asp Thr Asp Ser
    130                 135                 140                 
Ala Leu Ser Glu Val Pro Gln Leu Lys Gln Glu Ile Ser Glu Cys Leu
145                 150                 155                 160 
Ile Ala Ser Ser Phe Glu Asp Asp Ser Arg Val Ala Ser Pro Leu Asp
                165                 170                 175     
Gln Asn Gly Ser Phe Asn Val Val Ile Lys Glu Glu Pro Leu Asp Asp
            180                 185                 190         
Tyr Asp Tyr Glu Leu Gly Glu Cys Pro Glu Gly Val Thr Val Lys Gln
        195                 200                 205             
Glu Glu Thr Asp Glu Glu Thr Asp Val Tyr Ser Asn Ser Asp Asp Asp
    210                 215                 220                 
Pro Ile Leu Glu Lys Gln Leu Lys Arg His Asn Lys Val Asp Asn Pro
225                 230                 235                 240 
Glu Ala Asp His Leu Ser Ser Lys Trp Leu Pro Ser Ser Pro Ser Gly
                245                 250                 255     
Val Ala Lys Ala Lys Met Phe Lys Leu Asp Thr Gly Lys Met Pro Val
            260                 265                 270         
Val Tyr Leu Glu Pro Cys Ala Val Thr Arg Ser Thr Val Lys Ile Ser
        275                 280                 285             
Glu Leu Pro Asp Asn Met Leu Ser Thr Ser Arg Lys Asp Lys Ser Ser
    290                 295                 300                 
Met Leu Ala Glu Leu Glu Tyr Leu Pro Thr Tyr Ile Glu Asn Ser Asn
305                 310                 315                 320 
Glu Thr Ala Phe Cys Leu Gly Lys Glu Ser Glu Asn Gly Leu Arg Lys
                325                 330                 335     
His Ser Pro Asp Leu Arg Val Val Gln Lys Tyr Pro Leu Leu Lys Glu
            340                 345                 350         
Pro Gln Trp Lys Tyr Pro Asp Ile Ser Asp Ser Ile Ser Thr Glu Arg
        355                 360                 365             
Ile Leu Asp Asp Ser Lys Asp Ser Val Gly Asp Ser Leu Ser Gly Lys
    370                 375                 380                 
Glu Asp Leu Gly Arg Lys Arg Thr Thr Met Leu Lys Ile Ala Thr Ala
385                 390                 395                 400 
Ala Lys Val Val Asn Ala Asn Gln Asn Ala Ser Pro Asn Val Pro Gly
                405                 410                 415     
Lys Arg Gly Arg Pro Arg Lys Leu Lys Leu Cys Lys Ala Gly Arg Pro
            420                 425                 430         
Pro Lys Asn Thr Gly Lys Ser Leu Ile Ser Thr Lys Asn Thr Pro Val
        435                 440                 445             
Ser Pro Gly Ser Thr Phe Pro Asp Val Lys Pro Asp Leu Glu Asp Val
    450                 455                 460                 
Asp Gly Val Leu Phe Val Ser Phe Glu Ser Lys Glu Ala Leu Asp Ile
465                 470                 475                 480 
His Ala Val Asp Gly Thr Thr Glu Glu Ser Ser Ser Leu Gln Ala Ser
                485                 490                 495     
Thr Thr Asn Asp Ser Gly Tyr Arg Ala Arg Ile Ser Gln Leu Glu Lys
            500                 505                 510         
Glu Leu Ile Glu Asp Leu Lys Ser Leu Arg His Lys Gln Val Ile His
        515                 520                 525             
Pro Gly Leu Gln Glu Val Gly Leu Lys Leu Asn Ser Val Asp Pro Thr
    530                 535                 540                 
Met Arg Ile Asp Leu Lys Tyr Leu Gly Val Gln Leu Pro Leu Ala Pro
545                 550                 555                 560 
Ala Thr Ser Phe Pro Phe Trp Asn Leu Thr Gly Thr Asn Pro Ala Ser
                565                 570                 575     
Pro Asp Ala Gly Phe Pro Phe Val Ser Arg Thr Gly Lys Thr Asn Asp
            580                 585                 590         
Phe Thr Lys Ile Lys Gly Trp Arg Gly Lys Phe His Ser Ala Ser Ala
        595                 600                 605             
Ser Arg Asn Glu Gly Gly Asn Ser Glu Ser Ser Leu Lys Asn Arg Ser
    610                 615                 620                 
Ala Phe Cys Ser Asp Lys Leu Asp Glu Tyr Leu Glu Asn Glu Gly Lys
625                 630                 635                 640 
Leu Met Glu Thr Ser Met Gly Phe Ser Ser Asn Ala Pro Thr Ser Pro
                645                 650                 655     
Val Val Tyr Gln Leu Pro Thr Lys Ser Thr Ser Tyr Val Arg Thr Leu
            660                 665                 670         
Asp Ser Val Leu Lys Lys Gln Ser Thr Ile Ser Pro Ser Thr Ser Tyr
        675                 680                 685             
Ser Leu Lys Pro His Ser Val Pro Pro Val Ser Arg Lys Ala Lys Ser
    690                 695                 700                 
Gln Asn Arg Gln Ala Thr Phe Ser Gly Arg Thr Lys Ser Ser Tyr Lys
705                 710                 715                 720 
Ser Ile Leu Pro Tyr Pro Val Ser Pro Lys Gln Lys Tyr Ser His Val
                725                 730                 735     
Ile Leu Gly Asp Lys Val Thr Lys Asn Ser Ser Gly Ile Ile Ser Glu
            740                 745                 750         
Asn Gln Ala Asn Asn Phe Val Val Pro Thr Leu Asp Glu Asn Ile Phe
        755                 760                 765             
Pro Lys Gln Ile Ser Leu Arg Gln Ala Gln Gln Gln Gln Gln Gln Gln
    770                 775                 780                 
Gln Gly Ser Arg Pro Pro Gly Leu Ser Lys Ser Gln Val Lys Leu Met
785                 790                 795                 800 
Asp Leu Glu Asp Cys Ala Leu Trp Glu Gly Lys Pro Arg Thr Tyr Ile
                805                 810                 815     
Thr Glu Glu Arg Ala Asp Val Ser Leu Thr Thr Leu Leu Thr Ala Gln
            820                 825                 830         
Ala Ser Leu Lys Thr Lys Pro Ile His Thr Ile Ile Arg Lys Arg Ala
        835                 840                 845             
Pro Pro Cys Asn Asn Asp Phe Cys Arg Leu Gly Cys Val Cys Ser Ser
    850                 855                 860                 
Leu Ala Leu Glu Lys Arg Gln Pro Ala His Cys Arg Arg Pro Asp Cys
865                 870                 875                 880 
Met Phe Gly Cys Thr Cys Leu Lys Arg Lys Val Val Leu Val Lys Gly
                885                 890                 895     
Gly Ser Lys Thr Lys His Phe Gln Arg Lys Ala Ala His Arg Asp Pro
            900                 905                 910         
Val Phe Tyr Asp Thr Leu Gly Glu Glu Ala Arg Glu Glu Glu Glu Gly
        915                 920                 925             
Ile Arg Glu Glu Glu Glu Gln Leu Lys Glu
    930                 935             


<210> 1045
<211> 255
<212> PRT
<213> Homo sapiens

<400> 1045
Met Glu Leu Leu Val Ala Arg Thr Gln Met Ile Ser Val Ser Arg Ala
 1               5                  10                  15      
Phe Ala Gly Lys Leu Lys Phe Leu Arg Val Lys Thr Val Pro Leu Leu
            20                  25                  30          
Ser Lys Val Asp Asp Ile His Ala Ile Cys Ser Leu Leu Lys Asp Phe
        35                  40                  45              
Leu Arg Asn Leu Lys Glu Pro Leu Leu Thr Phe Arg Leu Asn Arg Ala
    50                  55                  60                  
Phe Met Glu Ala Ala Glu Ile Thr Asp Glu Asp Asn Ser Ile Ala Ala
65                  70                  75                  80  
Met Tyr Gln Ala Val Gly Glu Leu Pro Gln Ala Asn Arg Asp Thr Leu
                85                  90                  95      
Ala Phe Leu Met Ile His Leu Gln Arg Val Ala Gln Ser Pro His Thr
            100                 105                 110         
Lys Met Asp Val Ala Asn Leu Ala Lys Val Phe Gly Pro Thr Ile Val
        115                 120                 125             
Ala His Ala Val Pro Asn Pro Asp Pro Val Thr Met Leu Gln Asp Ile
    130                 135                 140                 
Lys Arg Gln Pro Lys Val Val Glu Arg Leu Leu Ser Leu Pro Leu Glu
145                 150                 155                 160 
Tyr Trp Ser Gln Phe Met Met Val Glu Gln Glu Asn Ile Asp Pro Leu
                165                 170                 175     
His Val Ile Glu Asn Ser Asn Ala Phe Ser Thr Pro Gln Thr Pro Asp
            180                 185                 190         
Ile Lys Val Ser Leu Leu Gly Pro Val Thr Thr Pro Glu His Gln Leu
        195                 200                 205             
Leu Lys Thr Pro Ser Ser Ser Ser Leu Ser Gln Arg Val Arg Ser Thr
    210                 215                 220                 
Leu Thr Lys Asn Thr Pro Arg Phe Gly Ser Lys Ser Lys Ser Ala Thr
225                 230                 235                 240 
Asn Leu Gly Arg Gln Gly Asn Phe Phe Ala Ser Pro Met Leu Lys
                245                 250                 255 


<210> 1046
<211> 846
<212> PRT
<213> Homo sapiens

<400> 1046
Met Lys Ala Val Pro Gly Thr Glu Val Pro Gly His Lys Asn Trp Val
 1               5                  10                  15      
Val Ser Lys Phe Gly Arg Val Leu Pro Val Leu His Leu Lys Asn Gln
            20                  25                  30          
His Lys Arg Lys Ile Ile Lys Tyr Asp Pro Ser Lys Tyr Cys His Asn
        35                  40                  45              
Leu Lys Lys Ile Gly Glu Asp Phe Ser Asn Thr Ile Pro Ile Ser Ser
    50                  55                  60                  
Leu Thr Trp Glu Leu Glu Gly Gly Asn Asp Pro Met Ser Lys Lys Arg
65                  70                  75                  80  
Arg Gly Glu Phe Ser Asp Phe His Gly Pro Pro Lys Lys Ile Ile Lys
                85                  90                  95      
Val Gln Lys Asp Glu Ser Ser Thr Gly Ser Leu Ala Met Ser Thr Arg
            100                 105                 110         
Pro Arg Arg Val Ile Glu Arg Pro Pro Leu Thr Gln Gln Gln Ala Ala
        115                 120                 125             
Gln Lys Arg Thr Cys Asp Ser Ile Thr Pro Ser Lys Ser Ser Pro Val
    130                 135                 140                 
Pro Val Ser Asp Thr Gln Lys Leu Lys Asn Leu Pro Phe Lys Thr Ser
145                 150                 155                 160 
Gly Leu Glu Thr Ala Lys Lys Arg Asn Ser Ile Ser Asp Asp Asp Thr
                165                 170                 175     
Asp Ser Glu Asp Glu Leu Arg Met Met Ile Ala Lys Glu Glu Asn Leu
            180                 185                 190         
Gln Arg Thr Thr Gln Pro Ser Ile Asn Glu Ser Glu Ser Asp Pro Phe
        195                 200                 205             
Glu Val Val Arg Asp Asp Phe Lys Ser Gly Val His Lys Leu His Ser
    210                 215                 220                 
Leu Ile Gly Leu Gly Ile Lys Asn Arg Val Ser Cys His Asp Ser Asp
225                 230                 235                 240 
Asp Asp Ile Met Arg Asn Asp Arg Glu Tyr Asp Ser Gly Asp Thr Asp
                245                 250                 255     
Glu Ile Ile Ala Met Lys Lys Asn Val Ala Lys Val Lys Asn Ser Thr
            260                 265                 270         
Glu Phe Ser Gln Met Glu Lys Ser Thr Lys Lys Thr Ser Phe Lys Asn
        275                 280                 285             
Arg Glu Asn Cys Glu Leu Ser Asp His Cys Ile Lys Leu Gln Lys Arg
    290                 295                 300                 
Lys Ser Asn Val Glu Ser Ala Leu Ser His Gly Leu Lys Ser Leu Asn
305                 310                 315                 320 
Arg Lys Ser Pro Ser His Ser Ser Ser Ser Glu Asp Ala Asp Ser Ala
                325                 330                 335     
Ser Glu Leu Ala Asp Ser Glu Gly Gly Glu Glu Tyr Asn Ala Met Met
            340                 345                 350         
Lys Asn Cys Leu Arg Val Asn Leu Thr Leu Ala Asp Leu Glu Gln Leu
        355                 360                 365             
Ala Gly Ser Asp Leu Lys Val Pro Asn Glu Asp Thr Lys Ser Asp Gly
    370                 375                 380                 
Pro Glu Thr Thr Thr Gln Cys Lys Phe Asp Arg Gly Ser Lys Ser Pro
385                 390                 395                 400 
Lys Thr Pro Thr Gly Leu Arg Arg Gly Arg Gln Cys Ile Arg Pro Ala
                405                 410                 415     
Glu Ile Val Ala Ser Leu Leu Glu Gly Glu Glu Asn Thr Cys Gly Lys
            420                 425                 430         
Gln Lys Pro Lys Glu Asn Asn Leu Lys Pro Lys Phe Gln Ala Phe Lys
        435                 440                 445             
Gly Val Gly Cys Leu Tyr Glu Lys Glu Ser Met Lys Lys Ser Leu Lys
    450                 455                 460                 
Asp Ser Val Ala Ser Asn Asn Lys Asp Gln Asn Ser Met Lys His Glu
465                 470                 475                 480 
Asp Pro Ser Ile Ile Ser Met Glu Asp Gly Ser Pro Tyr Val Asn Gly
                485                 490                 495     
Ser Leu Gly Glu Val Thr Pro Cys Gln His Ala Lys Lys Ala Asn Gly
            500                 505                 510         
Pro Asn Tyr Ile Gln Pro Gln Lys Arg Gln Thr Thr Phe Glu Ser Gln
        515                 520                 525             
Asp Arg Lys Ala Val Ser Pro Ser Ser Ser Glu Lys Arg Ser Lys Asn
    530                 535                 540                 
Pro Ile Ser Arg Pro Leu Glu Gly Lys Lys Ser Leu Ser Leu Ser Ala
545                 550                 555                 560 
Lys Thr His Asn Ile Gly Phe Asp Lys Asp Ser Cys His Ser Thr Thr
                565                 570                 575     
Lys Thr Glu Ala Ser Gln Glu Glu Arg Ser Asp Ser Ser Gly Leu Thr
            580                 585                 590         
Ser Leu Lys Lys Ser Pro Lys Val Ser Ser Lys Asp Thr Arg Glu Ile
        595                 600                 605             
Lys Thr Asp Phe Ser Leu Ser Ile Ser Asn Ser Ser Asp Val Ser Ala
    610                 615                 620                 
Lys Asp Lys His Ala Glu Asp Asn Glu Lys Arg Leu Ala Ala Leu Glu
625                 630                 635                 640 
Ala Arg Gln Lys Ala Lys Glu Val Gln Lys Lys Leu Val His Asn Ala
                645                 650                 655     
Leu Ala Asn Leu Asp Gly His Pro Glu Asp Lys Pro Thr His Ile Ile
            660                 665                 670         
Phe Gly Ser Asp Ser Glu Cys Glu Thr Glu Glu Thr Ser Thr Gln Glu
        675                 680                 685             
Gln Ser His Pro Gly Glu Glu Trp Val Lys Glu Ser Met Gly Lys Thr
    690                 695                 700                 
Ser Gly Lys Leu Phe Asp Ser Ser Asp Asp Asp Glu Ser Asp Ser Glu
705                 710                 715                 720 
Asp Asp Ser Asn Arg Phe Lys Ile Lys Pro Gln Phe Glu Gly Arg Ala
                725                 730                 735     
Gly Gln Lys Leu Met Asp Leu Gln Ser His Phe Gly Thr Asp Asp Arg
            740                 745                 750         
Phe Arg Met Asp Ser Arg Phe Leu Glu Thr Asp Ser Glu Glu Glu Gln
        755                 760                 765             
Glu Glu Val Asn Glu Lys Lys Thr Ala Glu Glu Glu Glu Leu Ala Glu
    770                 775                 780                 
Glu Lys Lys Lys Ala Leu Asn Val Val Gln Ser Val Leu Gln Ile Asn
785                 790                 795                 800 
Leu Ser Asn Ser Thr Asn Arg Gly Ser Val Ala Ala Lys Lys Phe Lys
                805                 810                 815     
Asp Ile Ile His Tyr Asp Pro Thr Lys Gln Asp His Ala Thr Tyr Glu
            820                 825                 830         
Arg Lys Arg Asp Asp Lys Pro Lys Glu Ser Lys Ala Lys Arg
        835                 840                 845     


<210> 1047
<211> 785
<212> PRT
<213> Homo sapiens

<400> 1047
Met Ala Asp Leu Asp Ser Pro Pro Lys Leu Ser Gly Val Gln Gln Pro
 1               5                  10                  15      
Ser Glu Gly Val Gly Gly Gly Arg Cys Ser Glu Ile Ser Ala Glu Leu
            20                  25                  30          
Ile Arg Ser Leu Thr Glu Leu Gln Glu Leu Glu Ala Val Tyr Glu Arg
        35                  40                  45              
Leu Cys Gly Glu Glu Lys Val Val Glu Arg Glu Leu Asp Ala Leu Leu
    50                  55                  60                  
Glu Gln Gln Asn Thr Ile Glu Ser Lys Met Val Thr Leu His Arg Met
65                  70                  75                  80  
Gly Pro Asn Leu Gln Leu Ile Glu Gly Asp Ala Lys Gln Leu Ala Gly
                85                  90                  95      
Met Ile Thr Phe Thr Cys Asn Leu Ala Glu Asn Val Ser Ser Lys Val
            100                 105                 110         
Arg Gln Leu Asp Leu Ala Lys Asn Arg Leu Tyr Gln Ala Ile Gln Arg
        115                 120                 125             
Ala Asp Asp Ile Leu Asp Leu Lys Phe Cys Met Asp Gly Val Gln Thr
    130                 135                 140                 
Ala Leu Arg Ser Glu Asp Tyr Glu Gln Ala Ala Ala His Ile His Arg
145                 150                 155                 160 
Tyr Leu Cys Leu Asp Lys Ser Val Ile Glu Leu Ser Arg Gln Gly Lys
                165                 170                 175     
Gly Gly Ser Met Ile Asp Ala Asn Leu Lys Leu Leu Gln Glu Ala Glu
            180                 185                 190         
Gln Arg Leu Lys Ala Ile Val Ala Glu Lys Phe Ala Ile Ala Thr Lys
        195                 200                 205             
Glu Gly Asp Leu Pro Gln Val Glu Arg Phe Phe Lys Ile Phe Pro Leu
    210                 215                 220                 
Leu Gly Leu His Glu Glu Gly Leu Arg Arg Phe Ser Glu Tyr Leu Cys
225                 230                 235                 240 
Lys Gln Val Ala Ser Lys Ala Glu Glu Asn Leu Leu Met Val Leu Gly
                245                 250                 255     
Thr Asp Met Ser Asp Arg Arg Ala Ala Val Ile Phe Ala Asp Thr Leu
            260                 265                 270         
Thr Leu Leu Phe Glu Gly Ile Ala Arg Ile Val Glu Ala His Gln Pro
        275                 280                 285             
Ile Val Glu Thr Tyr Tyr Gly Pro Gly Arg Leu Tyr Thr Leu Ile Lys
    290                 295                 300                 
Tyr Leu Gln Val Glu Cys Asp Arg Gln Val Glu Lys Val Val Asp Lys
305                 310                 315                 320 
Phe Ile Lys Gln Arg Asp Tyr His Gln Gln Phe Arg His Val Gln Asn
                325                 330                 335     
Asn Leu Met Arg Asn Ser Thr Thr Glu Lys Ile Glu Pro Arg Glu Leu
            340                 345                 350         
Asp Pro Ile Leu Thr Glu Val Thr Leu Met Asn Ala Arg Ser Glu Leu
        355                 360                 365             
Tyr Leu Arg Phe Leu Lys Lys Arg Ile Ser Ser Asp Phe Glu Val Gly
    370                 375                 380                 
Asp Ser Met Ala Ser Glu Glu Val Lys Gln Glu His Gln Lys Cys Leu
385                 390                 395                 400 
Asp Lys Leu Leu Asn Asn Cys Leu Leu Ser Cys Thr Met Gln Glu Leu
                405                 410                 415     
Ile Gly Leu Tyr Val Thr Met Glu Glu Tyr Phe Met Arg Glu Thr Val
            420                 425                 430         
Asn Lys Ala Val Ala Leu Asp Thr Tyr Glu Lys Gly Gln Leu Thr Ser
        435                 440                 445             
Ser Met Val Asp Asp Val Phe Tyr Ile Val Lys Lys Cys Ile Gly Arg
    450                 455                 460                 
Ala Leu Ser Ser Ser Ser Ile Asp Cys Leu Cys Ala Met Ile Asn Leu
465                 470                 475                 480 
Ala Thr Thr Glu Leu Glu Ser Asp Phe Arg Asp Val Leu Cys Asn Lys
                485                 490                 495     
Leu Arg Met Gly Phe Pro Ala Thr Thr Phe Gln Asp Ile Gln Arg Gly
            500                 505                 510         
Val Thr Ser Ala Val Asn Ile Met His Ser Ser Leu Gln Gln Gly Lys
        515                 520                 525             
Phe Asp Thr Lys Gly Ile Glu Ser Thr Asp Glu Ala Lys Met Ser Phe
    530                 535                 540                 
Leu Val Thr Leu Asn Asn Val Glu Val Cys Ser Glu Asn Ile Ser Thr
545                 550                 555                 560 
Leu Lys Lys Thr Leu Glu Ser Asp Cys Thr Lys Leu Phe Ser Gln Gly
                565                 570                 575     
Ile Gly Gly Glu Gln Ala Gln Ala Lys Phe Asp Gly Cys Leu Ser Asp
            580                 585                 590         
Leu Ala Ala Val Ser Asn Lys Phe Arg Asp Leu Leu Gln Glu Gly Leu
        595                 600                 605             
Thr Glu Leu Asn Ser Thr Ala Ile Lys Pro Gln Val Gln Pro Trp Ile
    610                 615                 620                 
Asn Ser Phe Phe Ser Val Ser His Asn Ile Glu Glu Glu Glu Phe Asn
625                 630                 635                 640 
Asp Tyr Glu Ala Asn Asp Pro Trp Val Gln Gln Phe Ile Leu Asn Leu
                645                 650                 655     
Glu Gln Gln Met Ala Glu Phe Lys Ala Ser Leu Ser Pro Val Ile Tyr
            660                 665                 670         
Asp Ser Leu Thr Gly Leu Met Thr Ser Leu Val Ala Val Glu Leu Glu
        675                 680                 685             
Lys Val Val Leu Lys Ser Thr Phe Asn Arg Leu Gly Gly Leu Gln Phe
    690                 695                 700                 
Asp Lys Glu Leu Arg Ser Leu Ile Ala Tyr Leu Thr Thr Val Thr Thr
705                 710                 715                 720 
Trp Thr Ile Arg Asp Lys Phe Ala Arg Leu Ser Gln Met Ala Thr Ile
                725                 730                 735     
Leu Asn Leu Glu Arg Val Thr Glu Ile Leu Asp Tyr Trp Gly Pro Asn
            740                 745                 750         
Ser Gly Pro Leu Thr Trp Arg Leu Thr Pro Ala Glu Val Arg Gln Val
        755                 760                 765             
Leu Ala Leu Arg Ile Asp Phe Arg Ser Glu Asp Ile Lys Arg Leu Arg
    770                 775                 780                 
Leu
785 


<210> 1048
<211> 401
<212> PRT
<213> Homo sapiens

<400> 1048
Met Asp Arg Glu Thr Arg Ala Leu Ala Asp Ser His Phe Arg Gly Leu
 1               5                  10                  15      
Gly Val Asp Val Pro Gly Val Gly Gln Ala Pro Gly Arg Val Ala Phe
            20                  25                  30          
Val Ser Glu Pro Gly Ala Phe Ser Tyr Ala Asp Phe Val Arg Gly Phe
        35                  40                  45              
Leu Leu Pro Asn Leu Pro Cys Val Phe Ser Ser Ala Phe Thr Gln Gly
    50                  55                  60                  
Trp Gly Ser Arg Arg Arg Trp Val Thr Pro Ala Gly Arg Pro Asp Phe
65                  70                  75                  80  
Asp His Leu Leu Arg Thr Tyr Gly Asp Val Val Val Pro Val Ala Asn
                85                  90                  95      
Cys Gly Val Gln Glu Tyr Asn Ser Asn Pro Lys Glu His Met Thr Leu
            100                 105                 110         
Arg Asp Tyr Ile Thr Tyr Trp Lys Glu Tyr Ile Gln Ala Gly Tyr Ser
        115                 120                 125             
Ser Pro Arg Gly Cys Leu Tyr Leu Lys Asp Trp His Leu Cys Arg Asp
    130                 135                 140                 
Phe Pro Val Glu Asp Val Phe Thr Leu Pro Val Tyr Phe Ser Ser Asp
145                 150                 155                 160 
Trp Leu Asn Glu Phe Trp Asp Ala Leu Asp Val Asp Asp Tyr Arg Phe
                165                 170                 175     
Val Tyr Ala Gly Pro Ala Gly Ser Trp Ser Pro Phe His Ala Asp Ile
            180                 185                 190         
Phe Arg Ser Phe Ser Arg Ser Val Asn Val Cys Gly Arg Lys Lys Trp
        195                 200                 205             
Leu Leu Phe Pro Pro Gly Gln Glu Glu Ala Leu Arg Asp Arg His Gly
    210                 215                 220                 
Asn Leu Pro Tyr Asp Val Thr Ser Pro Ala Leu Cys Asp Thr His Leu
225                 230                 235                 240 
His Pro Arg Asn Gln Leu Ala Gly Pro Pro Leu Glu Ile Thr Gln Glu
                245                 250                 255     
Ala Gly Glu Met Val Phe Val Pro Ser Gly Trp His His Gln Val His
            260                 265                 270         
Asn Leu Asp Asp Thr Ile Ser Ile Asn His Asn Trp Val Asn Gly Phe
        275                 280                 285             
Asn Leu Ala Asn Met Trp Arg Phe Leu Gln Gln Glu Leu Cys Ala Val
    290                 295                 300                 
Gln Glu Glu Val Ile Met Arg Ser Cys Ser Gly Ile Asn Phe Glu Glu
305                 310                 315                 320 
Phe Tyr His Phe Leu Lys Val Ile Ala Glu Lys Arg Leu Leu Val Leu
                325                 330                 335     
Arg Glu Ala Ala Ala Glu Asp Gly Ala Gly Leu Gly Phe Glu Gln Ala
            340                 345                 350         
Ala Phe Asp Val Gly Arg Ile Thr Glu Val Leu Ala Ser Leu Val Ala
        355                 360                 365             
His Pro Asp Phe Gln Arg Val Asp Thr Ser Ala Phe Ser Pro Arg Pro
    370                 375                 380                 
Lys Glu Leu Leu Gln Gln Leu Arg Glu Ala Val Asp Ala Ala Ala Ala
385                 390                 395                 400 
Pro
    


<210> 1049
<211> 803
<212> PRT
<213> Homo sapiens

<400> 1049
Met Asn Met Phe Lys Glu Ala Val Thr Phe Lys Asp Val Ala Val Ala
 1               5                  10                  15      
Phe Thr Glu Glu Glu Leu Gly Leu Leu Gly Pro Ala Gln Arg Lys Leu
            20                  25                  30          
Tyr Arg Asp Val Met Val Glu Asn Phe Arg Asn Leu Leu Ser Val Gly
        35                  40                  45              
His Pro Pro Phe Lys Gln Asp Val Ser Pro Ile Glu Arg Asn Glu Gln
    50                  55                  60                  
Leu Trp Ile Met Thr Thr Ala Thr Arg Arg Gln Gly Asn Leu Gly Glu
65                  70                  75                  80  
Lys Asn Gln Ser Lys Leu Ile Thr Val Gln Asp Arg Glu Ser Glu Glu
                85                  90                  95      
Glu Leu Ser Cys Trp Gln Ile Trp Gln Gln Ile Ala Asn Asp Leu Thr
            100                 105                 110         
Arg Cys Gln Asp Ser Met Ile Asn Asn Ser Gln Cys His Lys Gln Gly
        115                 120                 125             
Asp Phe Pro Tyr Gln Val Gly Thr Glu Leu Ser Ile Gln Ile Ser Glu
    130                 135                 140                 
Asp Glu Asn Tyr Ile Val Asn Lys Ala Asp Gly Pro Asn Asn Thr Gly
145                 150                 155                 160 
Asn Pro Glu Phe Pro Ile Leu Arg Thr Gln Asp Ser Trp Arg Lys Thr
                165                 170                 175     
Phe Leu Thr Glu Ser Gln Arg Leu Asn Arg Asp Gln Gln Ile Ser Ile
            180                 185                 190         
Lys Asn Lys Leu Cys Gln Cys Lys Lys Gly Val Asp Pro Ile Gly Trp
        195                 200                 205             
Ile Ser His His Asp Gly His Arg Val His Lys Ser Glu Lys Ser Tyr
    210                 215                 220                 
Arg Pro Asn Asp Tyr Glu Lys Asp Asn Met Lys Ile Leu Thr Phe Asp
225                 230                 235                 240 
His Asn Ser Met Ile His Thr Gly Gln Lys Ser Tyr Gln Cys Asn Glu
                245                 250                 255     
Cys Lys Lys Pro Phe Ser Asp Leu Ser Ser Phe Asp Leu His Gln Gln
            260                 265                 270         
Leu Gln Ser Gly Glu Lys Ser Leu Thr Cys Val Glu Arg Gly Lys Gly
        275                 280                 285             
Phe Cys Tyr Ser Pro Val Leu Pro Val His Gln Lys Val His Val Gly
    290                 295                 300                 
Glu Lys Leu Lys Cys Asp Glu Cys Gly Lys Glu Phe Ser Gln Gly Ala
305                 310                 315                 320 
His Leu Gln Thr His Gln Lys Val His Val Ile Glu Lys Pro Tyr Lys
                325                 330                 335     
Cys Lys Gln Cys Gly Lys Gly Phe Ser Arg Arg Ser Ala Leu Asn Val
            340                 345                 350         
His Cys Lys Val His Thr Ala Glu Lys Pro Tyr Asn Cys Glu Glu Cys
        355                 360                 365             
Gly Arg Ala Phe Ser Gln Ala Ser His Leu Gln Asp His Gln Arg Leu
    370                 375                 380                 
His Thr Gly Glu Lys Pro Phe Lys Cys Asp Ala Cys Gly Lys Ser Phe
385                 390                 395                 400 
Ser Arg Asn Ser His Leu Gln Ser His Gln Arg Val His Thr Gly Glu
                405                 410                 415     
Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Gly Phe Ile Cys Ser Ser
            420                 425                 430         
Asn Leu Tyr Ile His Gln Arg Val His Thr Gly Glu Lys Pro Tyr Lys
        435                 440                 445             
Cys Glu Glu Cys Gly Lys Gly Phe Ser Arg Pro Ser Ser Leu Gln Ala
    450                 455                 460                 
His Gln Gly Val His Thr Gly Glu Lys Ser Tyr Ile Cys Thr Val Cys
465                 470                 475                 480 
Gly Lys Gly Phe Thr Leu Ser Ser Asn Leu Gln Ala His Gln Arg Val
                485                 490                 495     
His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Ser Phe
            500                 505                 510         
Arg Arg Asn Ser His Tyr Gln Val His Leu Val Val His Thr Gly Glu
        515                 520                 525             
Lys Pro Tyr Lys Cys Glu Ile Cys Gly Lys Gly Phe Ser Gln Ser Ser
    530                 535                 540                 
Tyr Leu Gln Ile His Gln Lys Ala His Ser Ile Glu Lys Pro Phe Lys
545                 550                 555                 560 
Cys Glu Glu Cys Gly Gln Gly Phe Asn Gln Ser Ser Arg Leu Gln Ile
                565                 570                 575     
His Gln Leu Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys
            580                 585                 590         
Gly Lys Gly Phe Ser Arg Arg Ala Asp Leu Lys Ile His Cys Arg Ile
        595                 600                 605             
His Thr Gly Glu Lys Pro Tyr Asn Cys Glu Glu Cys Gly Lys Val Phe
    610                 615                 620                 
Arg Gln Ala Ser Asn Leu Leu Ala His Gln Arg Val His Ser Gly Glu
625                 630                 635                 640 
Lys Pro Phe Lys Cys Glu Glu Cys Gly Lys Ser Phe Gly Arg Ser Ala
                645                 650                 655     
His Leu Gln Ala His Gln Lys Val His Thr Gly Asp Lys Pro Tyr Lys
            660                 665                 670         
Cys Asp Glu Cys Gly Lys Gly Phe Lys Trp Ser Leu Asn Leu Asp Met
        675                 680                 685             
His Gln Arg Val His Thr Gly Glu Lys Pro Tyr Lys Cys Gly Glu Cys
    690                 695                 700                 
Gly Lys Tyr Phe Ser Gln Ala Ser Ser Leu Gln Leu His Gln Ser Val
705                 710                 715                 720 
His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Val Cys Gly Lys Val Phe
                725                 730                 735     
Ser Arg Ser Ser Gln Leu Gln Ser His Gln Arg Val His Thr Gly Glu
            740                 745                 750         
Lys Pro Tyr Lys Cys Glu Ile Cys Gly Lys Ser Phe Ser Trp Arg Ser
        755                 760                 765             
Asn Leu Thr Val His His Arg Ile His Val Gly Asp Lys Ser Tyr Lys
    770                 775                 780                 
Ser Asn Arg Gly Gly Lys Asn Ile Arg Glu Ser Thr Gln Glu Lys Lys
785                 790                 795                 800 
Ser Ile Lys
            


<210> 1050
<211> 502
<212> PRT
<213> Homo sapiens

<400> 1050
Met Lys Thr Asp Ser Ile Gln Asn Arg Thr Ala Arg Ala Leu Gly Asn
 1               5                  10                  15      
Leu Ala Met Glu Pro Glu Ser Cys Gly Asp Ile His Cys Ala Gly Ala
            20                  25                  30          
Val Pro Leu Leu Val Glu Ser Leu Thr Ala Cys Gln Asp Ser Gln Cys
        35                  40                  45              
Leu Gln Ser Val Val Arg Ala Leu Arg Asn Leu Ala Asp Ser Pro Gln
    50                  55                  60                  
His Arg Leu Ala Leu Ala Gln Gln Gly Ala Val Arg Pro Leu Ala Glu
65                  70                  75                  80  
Leu Leu Ala Thr Ala Pro Asp Ala Ala Leu Thr Leu Ala Leu Val Arg
                85                  90                  95      
Ala Leu Leu Glu Leu Ser Arg Gly Cys Ser Arg Ala Cys Ala Glu Gln
            100                 105                 110         
Leu Ser Leu Gly Gly Gly Leu Gly Pro Leu Val Ser Leu Ala Ser His
        115                 120                 125             
Pro Lys Arg Ala Val Arg Glu Gly Thr Ile Leu Ile Leu Ala Asn Leu
    130                 135                 140                 
Cys Ala Gln Gly Leu Ile Arg Pro Ala Leu Gly Asn Ala Gly Gly Val
145                 150                 155                 160 
Glu Val Leu Val Asp Glu Leu Arg Gln Arg Arg Asp Pro Asn Gly Ala
                165                 170                 175     
Ser Pro Thr Ser Gln Gln Pro Leu Val Arg Ala Val Cys Leu Leu Cys
            180                 185                 190         
Arg Glu Ala Ile Asn Arg Ala Arg Leu Arg Asp Ala Gly Gly Leu Asp
        195                 200                 205             
Leu Leu Met Gly Leu Leu Arg Asp Pro Arg Ala Ser Ala Trp His Pro
    210                 215                 220                 
Arg Ile Val Ala Ala Leu Val Gly Phe Leu Tyr Asp Thr Gly Ala Leu
225                 230                 235                 240 
Gly Arg Leu Gln Ala Leu Gly Leu Val Pro Leu Leu Ala Gly Gln Leu
                245                 250                 255     
Cys Gly Glu Ala Gly Glu Glu Glu Glu Glu Gly Arg Glu Ala Ala Ser
            260                 265                 270         
Trp Asp Phe Pro Glu Glu Arg Thr Pro Glu Arg Ala Gln Gly Gly Ser
        275                 280                 285             
Phe Arg Ser Leu Arg Ser Trp Leu Ile Ser Glu Gly Tyr Ala Thr Gly
    290                 295                 300                 
Pro Asp Asp Ile Ser Pro Asp Trp Ser Pro Glu Gln Cys Pro Pro Glu
305                 310                 315                 320 
Pro Met Glu Pro Ala Ser Pro Ala Pro Thr Pro Thr Ser Leu Arg Ala
                325                 330                 335     
Pro Arg Thr Gln Arg Thr Pro Gly Arg Ser Pro Ala Ala Ala Ile Glu
            340                 345                 350         
Glu Pro Trp Gly Arg Glu Gly Pro Ala Leu Leu Leu Leu Ser Arg Phe
        355                 360                 365             
Ser Gln Ala Pro Asp Pro Ser Gly Ala Leu Val Thr Gly Pro Ala Leu
    370                 375                 380                 
Tyr Gly Leu Leu Thr Tyr Val Thr Gly Ala Pro Gly Pro Pro Ser Pro
385                 390                 395                 400 
Arg Ala Leu Arg Ile Leu Ser Arg Leu Thr Cys Asn Pro Ala Cys Leu
                405                 410                 415     
Glu Ala Phe Val Arg Ser Tyr Gly Ala Ala Leu Leu Arg Ala Trp Leu
            420                 425                 430         
Val Leu Gly Val Ala Pro Asp Asp Trp Pro Ala Pro Arg Ala Arg Pro
        435                 440                 445             
Thr Leu His Ser Arg His Arg Glu Leu Gly Glu Arg Leu Leu Gln Asn
    450                 455                 460                 
Leu Thr Val Gln Ala Glu Ser Pro Phe Gly Val Gly Ala Leu Thr His
465                 470                 475                 480 
Leu Leu Leu Ser Gly Ser Pro Glu Asp Arg Val Ala Cys Ala Leu Thr
                485                 490                 495     
Leu Pro Phe Ile Cys Arg
            500         


<210> 1051
<211> 476
<212> PRT
<213> Homo sapiens

<400> 1051
Met Glu Gly Ser Ala Ser Glu Val Leu Lys Glu Trp Thr Val Thr Gly
 1               5                  10                  15      
Lys Lys Lys Asn Lys Lys Lys Lys Asn Lys Pro Lys Pro Ala Ala Glu
            20                  25                  30          
Pro Ser Asn Gly Ile Pro Asp Ser Ser Lys Ser Val Ser Ile Gln Glu
        35                  40                  45              
Glu Gln Ser Ala Pro Ser Ser Glu Lys Gly Gly Met Asn Gly Tyr His
    50                  55                  60                  
Val Asn Gly Ala Ile Asn Asp Thr Glu Ser Val Asp Ser Leu Ser Glu
65                  70                  75                  80  
Gly Leu Glu Thr Leu Ser Ile Asp Ala Arg Glu Leu Glu Asp Pro Glu
                85                  90                  95      
Ser Ala Met Leu Asp Thr Leu Asp Arg Thr Gly Ser Met Leu Gln Asn
            100                 105                 110         
Gly Val Ser Asp Phe Glu Thr Lys Ser Leu Thr Met His Ser Ile His
        115                 120                 125             
Asn Ser Gln Gln Pro Arg Asn Ala Ala Lys Ser Leu Ser Arg Pro Thr
    130                 135                 140                 
Thr Glu Thr Gln Phe Ser Asn Met Gly Met Glu Asp Val Pro Leu Ala
145                 150                 155                 160 
Thr Ser Lys Lys Leu Ser Ser Asn Ile Glu Lys Ser Val Lys Asp Leu
                165                 170                 175     
Gln Arg Cys Thr Val Ser Leu Ala Arg Tyr Arg Val Val Val Lys Glu
            180                 185                 190         
Glu Met Asp Ala Ser Ile Lys Lys Met Lys Gln Ala Phe Ala Glu Leu
        195                 200                 205             
Glu Ser Cys Leu Met Asp Arg Glu Val Ala Leu Leu Ala Glu Met Asp
    210                 215                 220                 
Lys Val Lys Ala Glu Ala Met Glu Ile Leu Leu Ser Arg Gln Lys Lys
225                 230                 235                 240 
Ala Glu Leu Leu Lys Lys Met Thr His Val Ala Val Gln Met Ser Glu
                245                 250                 255     
Gln Gln Leu Val Glu Leu Arg Ala Asp Ile Lys His Phe Val Ser Glu
            260                 265                 270         
Arg Lys Tyr Asp Glu Asp Leu Gly Arg Val Ala Arg Phe Thr Cys Asp
        275                 280                 285             
Val Glu Thr Leu Lys Lys Ser Ile Asp Ser Phe Gly Gln Val Ser His
    290                 295                 300                 
Pro Lys Asn Ser Tyr Ser Thr Arg Ser Arg Cys Ser Ser Val Thr Ser
305                 310                 315                 320 
Val Ser Leu Ser Ser Pro Ser Asp Ala Ser Ala Ala Ser Ser Ser Thr
                325                 330                 335     
Cys Ala Ser Pro Pro Ser Leu Thr Ser Ala Asn Lys Lys Asn Phe Ala
            340                 345                 350         
Pro Gly Glu Thr Pro Ala Ala Ile Ala Asn Ser Ser Gly Gln Pro Tyr
        355                 360                 365             
Gln Pro Leu Arg Glu Val Leu Pro Gly Asn Arg Arg Gly Gly Gln Gly
    370                 375                 380                 
Tyr Arg Pro Gln Gly Gln Lys Ser Asn Asp Pro Met Asn Gln Gly Arg
385                 390                 395                 400 
His Asp Ser Met Gly Arg Tyr Arg Asn Ser Ser Trp Tyr Ser Ser Gly
                405                 410                 415     
Ser Arg Tyr Gln Ser Ala Pro Ser Gln Ala Pro Gly Asn Thr Ile Glu
            420                 425                 430         
Arg Gly Gln Thr His Ser Ala Gly Thr Asn Gly Thr Gly Val Ser Met
        435                 440                 445             
Glu Pro Ser Pro Pro Thr Pro Ser Phe Lys Lys Gly Leu Pro Gln Arg
    450                 455                 460                 
Lys Pro Arg Thr Ser Gln Thr Glu Ala Val Asn Ser
465                 470                 475     


<210> 1052
<211> 533
<212> PRT
<213> Homo sapiens

<400> 1052
Met Ser Gly Thr Leu Glu Ser Leu Ala Asp Asp Val Ser Ser Met Gly
 1               5                  10                  15      
Ser Asp Ser Glu Ile Asn Gly Leu Ala Leu Arg Lys Thr Asp Lys Tyr
            20                  25                  30          
Gly Phe Leu Gly Gly Ser Gln Tyr Ser Gly Ser Leu Glu Ser Ser Ile
        35                  40                  45              
Pro Val Asp Val Ala Arg Gln Arg Glu Leu Lys Trp Leu Asp Met Phe
    50                  55                  60                  
Ser Asn Trp Asp Lys Trp Leu Ser Arg Arg Phe Gln Lys Val Lys Leu
65                  70                  75                  80  
Arg Cys Arg Lys Gly Ile Pro Ser Ser Leu Arg Ala Lys Ala Trp Gln
                85                  90                  95      
Tyr Leu Ser Asn Ser Lys Glu Leu Leu Glu Gln Asn Pro Gly Lys Phe
            100                 105                 110         
Glu Glu Leu Glu Arg Ala Pro Gly Asp Pro Lys Trp Leu Asp Val Ile
        115                 120                 125             
Glu Lys Asp Leu His Arg Gln Phe Pro Phe His Glu Met Phe Ala Ala
    130                 135                 140                 
Arg Gly Gly His Gly Gln Gln Asp Leu Tyr Arg Ile Leu Lys Ala Tyr
145                 150                 155                 160 
Thr Ile Tyr Arg Pro Asp Glu Gly Tyr Cys Gln Ala Gln Ala Pro Val
                165                 170                 175     
Ala Ala Val Leu Leu Met His Met Pro Ala Glu Gln Ala Phe Trp Cys
            180                 185                 190         
Leu Val Gln Ile Cys Asp Lys Tyr Leu Pro Gly Tyr Tyr Ser Ala Gly
        195                 200                 205             
Leu Glu Ala Ile Gln Leu Asp Gly Glu Ile Phe Phe Ala Leu Leu Arg
    210                 215                 220                 
Arg Ala Ser Pro Leu Ala His Arg His Leu Arg Arg Gln Arg Ile Asp
225                 230                 235                 240 
Pro Val Leu Tyr Met Thr Glu Trp Phe Met Cys Ile Phe Ala Arg Thr
                245                 250                 255     
Leu Pro Trp Ala Ser Val Leu Arg Val Trp Asp Met Phe Phe Cys Glu
            260                 265                 270         
Gly Val Lys Ile Ile Phe Arg Val Ala Leu Val Leu Leu Arg His Thr
        275                 280                 285             
Leu Gly Ser Val Glu Lys Leu Arg Ser Cys Gln Gly Met Tyr Glu Thr
    290                 295                 300                 
Met Glu Gln Leu Arg Asn Leu Pro Gln Gln Cys Met Gln Glu Asp Phe
305                 310                 315                 320 
Leu Val His Glu Val Thr Asn Leu Pro Val Thr Glu Ala Leu Ile Glu
                325                 330                 335     
Arg Glu Asn Ala Ala Gln Leu Lys Lys Trp Arg Glu Thr Arg Gly Glu
            340                 345                 350         
Leu Gln Tyr Arg Pro Ser Arg Arg Leu His Gly Ser Arg Ala Ile His
        355                 360                 365             
Glu Glu Arg Arg Arg Gln Gln Pro Pro Leu Gly Pro Ser Ser Ser Leu
    370                 375                 380                 
Leu Ser Leu Pro Gly Leu Lys Ser Arg Gly Ser Arg Ala Ala Gly Gly
385                 390                 395                 400 
Ala Pro Ser Pro Pro Pro Pro Val Arg Arg Ala Ser Ala Gly Pro Ala
                405                 410                 415     
Pro Gly Pro Val Val Thr Ala Glu Gly Leu His Pro Ser Leu Pro Ser
            420                 425                 430         
Pro Thr Gly Asn Ser Thr Pro Leu Gly Ser Ser Lys Glu Thr Arg Lys
        435                 440                 445             
Gln Glu Lys Glu Arg Gln Lys Gln Glu Lys Glu Arg Gln Lys Gln Glu
    450                 455                 460                 
Lys Glu Arg Glu Lys Glu Arg Gln Lys Gln Glu Lys Glu Arg Glu Lys
465                 470                 475                 480 
Gln Glu Lys Glu Arg Glu Lys Gln Glu Lys Glu Arg Gln Lys Gln Glu
                485                 490                 495     
Lys Lys Ala Gln Gly Arg Lys Leu Ser Leu Arg Arg Lys Ala Asp Gly
            500                 505                 510         
Pro Pro Gly Pro His Asp Gly Gly Asp Arg Pro Ser Ala Glu Ala Arg
        515                 520                 525             
Gln Asp Ala Tyr Phe
    530             


<210> 1053
<211> 413
<212> PRT
<213> Homo sapiens

<400> 1053
Met Ala Ile Thr Ala Ala His Gly Ala Ser Thr Ala Val Gln Thr Gly
 1               5                  10                  15      
Asp Pro Ala Ser Lys Asp Gln Val Thr Thr Pro Trp Val Pro Ser Ser
            20                  25                  30          
Ala Leu Ile Val Ser Ser Asn Ala Arg Thr Ser Pro Arg Ala Val Leu
        35                  40                  45              
Trp Ser Met Ala Pro Gly Gly Ala Ala Pro Cys Pro Arg Leu Pro Ala
    50                  55                  60                  
Val Lys Thr Gly Cys Thr Ala Val Cys Asp Leu Ile Gln Ser Lys Cys
65                  70                  75                  80  
Leu Ser Lys Glu Asn Ala Thr Thr Asp Leu Leu Thr Lys Leu Pro Ala
                85                  90                  95      
His Thr Val Gly Asp Val Lys Cys Asp Met Glu Val Ser Cys Pro Asp
            100                 105                 110         
Gly Tyr Thr Cys Cys Arg Leu Gln Ser Gly Ala Trp Gly Cys Cys Pro
        115                 120                 125             
Phe Thr Gln Ala Val Cys Cys Glu Asp His Ile His Cys Cys Pro Ala
    130                 135                 140                 
Gly Phe Thr Cys Asp Thr Gln Lys Gly Thr Cys Glu Gln Gly Pro His
145                 150                 155                 160 
Gln Val Pro Trp Met Glu Lys Ala Pro Ala His Leu Ser Leu Pro Asp
                165                 170                 175     
Pro Gln Ala Leu Lys Arg Asp Val Pro Cys Asp Asn Val Ser Ser Cys
            180                 185                 190         
Pro Ser Ser Asp Thr Cys Cys Gln Leu Thr Ser Gly Glu Trp Gly Cys
        195                 200                 205             
Cys Pro Ile Pro Glu Ala Val Cys Cys Ser Asp His Gln His Cys Cys
    210                 215                 220                 
Pro Gln Gly Tyr Thr Cys Val Ala Glu Gly Gln Cys Gln Arg Gly Ser
225                 230                 235                 240 
Glu Ile Val Ala Gly Leu Glu Lys Met Pro Ala Arg Arg Ala Ser Leu
                245                 250                 255     
Ser His Pro Arg Asp Ile Gly Cys Asp Gln His Thr Ser Cys Pro Val
            260                 265                 270         
Gly Gln Thr Cys Cys Pro Ser Leu Gly Gly Ser Trp Ala Cys Cys Gln
        275                 280                 285             
Leu Pro His Ala Val Cys Cys Glu Asp Arg Gln His Cys Cys Pro Ala
    290                 295                 300                 
Gly Tyr Thr Cys Asn Val Lys Ala Arg Ser Cys Glu Lys Glu Val Val
305                 310                 315                 320 
Ser Ala Gln Pro Ala Thr Phe Leu Ala Arg Ser Pro His Val Gly Val
                325                 330                 335     
Lys Asp Val Glu Cys Gly Glu Gly His Phe Cys His Asp Asn Gln Thr
            340                 345                 350         
Cys Cys Arg Asp Asn Arg Gln Gly Trp Ala Cys Cys Pro Tyr Arg Gln
        355                 360                 365             
Gly Val Cys Cys Ala Asp Arg Arg His Cys Cys Pro Ala Gly Phe Arg
    370                 375                 380                 
Cys Ala Ala Arg Gly Thr Lys Cys Leu Arg Arg Glu Ala Pro Arg Trp
385                 390                 395                 400 
Asp Ala Pro Leu Arg Asp Pro Ala Leu Arg Gln Leu Leu
                405                 410             


<210> 1054
<211> 639
<212> PRT
<213> Homo sapiens

<400> 1054
Met Val Trp Glu Ile Leu Val Ser Glu Arg Asp Ile Arg Ala Leu Ile
 1               5                  10                  15      
Pro Leu Ala Lys Ala Glu Glu Leu Val Asn Thr Ala Pro Leu Thr Gly
            20                  25                  30          
Val Pro Gln His Val Pro Val Arg Leu Val Thr Val Asp Gly Gly Gly
        35                  40                  45              
Ala Leu Val Glu Val Thr Glu His Val Gly Cys Glu Ser Ala Asn Thr
    50                  55                  60                  
Gln Val Leu Gln Val Ser Glu Ala Cys Asp Ala Val Phe Val Ala Gly
65                  70                  75                  80  
Lys Glu Ser Arg Gly Ala Arg Gly Val Arg Val Asp Phe Trp Trp Arg
                85                  90                  95      
Arg Leu Arg Ala Ser Leu Arg Leu Thr Val Trp Ala Pro Leu Leu Pro
            100                 105                 110         
Leu Arg Ile Glu Leu Thr Asp Thr Thr Leu Glu Gln Val Arg Gly Trp
        115                 120                 125             
Arg Val Pro Gly Pro Ala Glu Gly Pro Ala Glu Pro Ala Ala Glu Ala
    130                 135                 140                 
Ser Asp Glu Ala Glu Arg Arg Ala Arg Gly Cys His Leu Gln Tyr Gln
145                 150                 155                 160 
Arg Ala Gly Val Arg Phe Leu Ala Pro Phe Ala Ala His Pro Leu Asp
                165                 170                 175     
Gly Gly Arg Arg Leu Thr His Leu Leu Gly Pro Asp Trp Leu Leu Asp
            180                 185                 190         
Val Ser His Leu Val Ala Pro His Ala Arg Val Leu Asp Ser Arg Val
        195                 200                 205             
Ala Ser Leu Glu Gly Gly Arg Val Val Val Gly Arg Glu Pro Gly Val
    210                 215                 220                 
Thr Ser Ile Glu Val Arg Ser Pro Leu Ser Asp Ser Ile Leu Gly Glu
225                 230                 235                 240 
Gln Ala Leu Ala Val Thr Asp Asp Lys Val Ser Val Leu Glu Leu Arg
                245                 250                 255     
Val Gln Pro Val Met Gly Ile Ser Leu Thr Leu Ser Arg Gly Thr Ala
            260                 265                 270         
His Pro Gly Glu Val Thr Ala Thr Cys Trp Ala Gln Ser Ala Leu Pro
        275                 280                 285             
Ala Pro Lys Gln Glu Val Ala Leu Ser Leu Trp Leu Ser Phe Ser Asp
    290                 295                 300                 
His Thr Val Ala Pro Ala Glu Leu Tyr Asp Arg Arg Asp Leu Gly Leu
305                 310                 315                 320 
Ser Val Ser Ala Glu Glu Pro Gly Ala Ile Leu Pro Ala Glu Glu Gln
                325                 330                 335     
Gly Ala Gln Leu Gly Val Val Val Ser Gly Ala Gly Ala Glu Gly Leu
            340                 345                 350         
Pro Leu His Val Ala Leu His Pro Pro Glu Pro Cys Arg Arg Gly Arg
        355                 360                 365             
His Arg Val Pro Leu Ala Ser Gly Thr Ala Trp Leu Gly Leu Pro Pro
    370                 375                 380                 
Ala Ser Thr Pro Ala Pro Ala Leu Pro Ser Ser Pro Ala Trp Ser Pro
385                 390                 395                 400 
Pro Ala Thr Glu Ala Thr Met Gly Gly Lys Arg Gln Val Ala Gly Ser
                405                 410                 415     
Val Gly Gly Asn Thr Gly Val Arg Gly Lys Phe Glu Arg Ala Glu Glu
            420                 425                 430         
Glu Ala Arg Lys Glu Glu Thr Lys Ala Arg Glu Glu Glu Glu Glu Glu
        435                 440                 445             
Glu Glu Glu Met Val Pro Ala Pro Gln His Val Thr Glu Leu Glu Leu
    450                 455                 460                 
Gly Met Tyr Ala Leu Leu Gly Val Phe Cys Val Ala Ile Phe Ile Phe
465                 470                 475                 480 
Leu Val Asn Gly Val Val Phe Val Leu Arg Tyr Gln Arg Lys Glu Pro
                485                 490                 495     
Pro Asp Ser Ala Thr Asp Pro Thr Ser Pro Gln Pro His Asn Trp Val
            500                 505                 510         
Trp Leu Gly Thr Asp Gln Glu Glu Leu Ser Arg Gln Leu Asp Arg Gln
        515                 520                 525             
Ser Pro Gly Pro Pro Lys Gly Glu Gly Ser Cys Pro Cys Glu Ser Gly
    530                 535                 540                 
Gly Gly Gly Glu Ala Pro Thr Leu Ala Pro Gly Pro Pro Gly Gly Thr
545                 550                 555                 560 
Thr Ser Ser Ser Ser Thr Leu Ala Arg Lys Glu Ala Gly Gly Arg Arg
                565                 570                 575     
Lys Arg Val Glu Phe Val Thr Phe Ala Pro Ala Pro Pro Ala Gln Ser
            580                 585                 590         
Pro Glu Glu Pro Val Gly Ala Pro Ala Val Gln Ser Ile Leu Val Ala
        595                 600                 605             
Gly Glu Glu Asp Ile Arg Trp Val Cys Glu Asp Met Gly Leu Lys Asp
    610                 615                 620                 
Pro Glu Glu Leu Arg Asn Tyr Met Glu Arg Ile Arg Gly Ser Ser
625                 630                 635                 


<210> 1055
<211> 1081
<212> PRT
<213> Homo sapiens

<400> 1055
Met Pro Leu Glu Gln Glu Ser Arg Met Glu Val Leu Ser Ala Cys Ala
 1               5                  10                  15      
Glu Ala Leu His Ala His Gly Tyr Ser Ser Glu Ala Ser Arg Leu Thr
            20                  25                  30          
Val Glu Leu Ala Gln Asp Leu Leu Ala Asn Pro Pro Asp Leu Lys Val
        35                  40                  45              
Glu Pro Pro Pro Ala Lys Gly Lys Lys Asn Lys Val Ser Thr Ser Arg
    50                  55                  60                  
Gln Thr Trp Val Ala Thr Asn Thr Leu Ser Lys Ala Ala Phe Leu Leu
65                  70                  75                  80  
Thr Val Leu Ser Glu Arg Pro Glu His His Asn Leu Ala Phe Arg Val
                85                  90                  95      
Gly Met Phe Ala Leu Glu Leu Gln Arg Pro Pro Ala Ser Thr Lys Ala
            100                 105                 110         
Leu Glu Val Lys Leu Ala Tyr Gln Glu Ser Glu Val Ala Ala Leu Leu
        115                 120                 125             
Lys Lys Ile Pro Leu Gly Pro Ser Glu Met Ser Thr Met Arg Cys Arg
    130                 135                 140                 
Ala Glu Glu Leu Arg Glu Gly Thr Leu Cys Asp Tyr Arg Pro Val Leu
145                 150                 155                 160 
Pro Leu Met Leu Ala Ser Phe Ile Phe Asp Val Leu Cys Ala Pro Val
                165                 170                 175     
Val Ser Pro Thr Gly Ser Arg Pro Pro Ser Arg Asn Trp Asn Ser Glu
            180                 185                 190         
Thr Pro Gly Asp Glu Glu Leu Gly Phe Glu Ala Ala Val Ala Ala Leu
        195                 200                 205             
Gly Met Lys Thr Thr Val Ser Glu Ala Glu His Pro Leu Leu Cys Glu
    210                 215                 220                 
Gly Thr Arg Arg Glu Lys Gly Asp Leu Ala Leu Ala Leu Met Ile Thr
225                 230                 235                 240 
Tyr Lys Asp Asp Gln Ala Lys Leu Lys Lys Ile Leu Asp Lys Leu Leu
                245                 250                 255     
Asp Arg Glu Ser Gln Thr His Lys Pro Gln Thr Leu Ser Ser Phe Tyr
            260                 265                 270         
Ser Ser Ser Arg Pro Thr Thr Ala Ser Gln Arg Ser Pro Ser Lys His
        275                 280                 285             
Gly Gly Pro Ser Ala Pro Gly Thr Leu Gln Pro Leu Thr Ser Gly Ser
    290                 295                 300                 
Ala Gly Pro Ala Gln Pro Gly Ser Val Ala Gly Ala Gly Pro Gly Pro
305                 310                 315                 320 
Thr Glu Gly Phe Thr Glu Lys Asn Val Pro Glu Ser Ser Pro His Ser
                325                 330                 335     
Pro Cys Glu Gly Leu Pro Ser Glu Ala Ala Leu Thr Pro Arg Pro Glu
            340                 345                 350         
Gly Lys Val Pro Ser Arg Leu Ala Leu Gly Ser Arg Gly Gly Tyr Asn
        355                 360                 365             
Gly Arg Gly Trp Gly Ser Pro Gly Arg Pro Lys Met Lys His Thr Gly
    370                 375                 380                 
Met Ala Ser Ile Asp Ser Ser Ala Pro Glu Thr Thr Ser Asp Ser Ser
385                 390                 395                 400 
Pro Thr Leu Ser Arg Arg Pro Leu Gln Gly Gly Trp Ala Pro Thr Ser
                405                 410                 415     
Trp Gly Arg Gly Gln Asp Ser Asp Ser Ile Ser Asn Ser Ser Ser Asp
            420                 425                 430         
Ser Leu Gly Ser Ser Ser Ser Ser Gly Ser Arg Arg Ala Ser Ala Ser
        435                 440                 445             
Gly Gly Ala Arg Ala Lys Thr Val Glu Val Gly Arg Tyr Lys Gly Arg
    450                 455                 460                 
Arg Pro Glu Ser His Ala Pro His Val Pro Asn Gln Pro Ser Glu Ala
465                 470                 475                 480 
Ala Ala His Phe Tyr Phe Glu Leu Ala Lys Thr Val Leu Ile Lys Thr
                485                 490                 495     
Gly Gly Asn Ser Ser Thr Ser Ile Phe Thr His Pro Ser Ser Ser Gly
            500                 505                 510         
Gly His Gln Gly Pro His Arg Asn Leu His Leu Cys Ala Phe Glu Ile
        515                 520                 525             
Gly Leu Tyr Ala Leu Gly Leu His Asn Phe Val Ser Pro Asn Trp Leu
    530                 535                 540                 
Ser Arg Thr Tyr Ser Ser His Val Ser Trp Ile Thr Gly Gln Ala Met
545                 550                 555                 560 
Glu Ile Gly Ser Ala Ala Leu Thr Ile Leu Val Glu Cys Trp Asp Gly
                565                 570                 575     
His Leu Thr Pro Pro Glu Val Ala Ser Leu Ala Asp Arg Ala Ser Arg
            580                 585                 590         
Ala Arg Asp Ser Asn Met Val Arg Ala Ala Ala Glu Leu Ala Leu Ser
        595                 600                 605             
Cys Leu Pro His Ala His Ala Leu Asn Pro Asn Glu Ile Gln Arg Ala
    610                 615                 620                 
Leu Val Gln Cys Lys Glu Gln Asp Asn Leu Met Leu Glu Lys Ala Cys
625                 630                 635                 640 
Met Ala Val Glu Val Ala Ala Lys Gly Gly Gly Val Tyr Pro Glu Val
                645                 650                 655     
Leu Phe Glu Val Ala His Gln Trp Phe Trp Leu Tyr Glu Gln Thr Ala
            660                 665                 670         
Gly Gly Ser Ser Thr Ala Arg Glu Gly Ala Thr Ser Cys Ser Ala Ser
        675                 680                 685             
Gly Ile Arg Ala Gly Gly Glu Ala Gly Arg Gly Met Pro Glu Gly Arg
    690                 695                 700                 
Gly Gly Pro Gly Thr Glu Pro Val Thr Val Ala Ala Ala Ala Val Thr
705                 710                 715                 720 
Ala Ala Ala Thr Val Val Pro Val Ile Ser Val Gly Ser Ser Leu Tyr
                725                 730                 735     
Pro Gly Pro Gly Leu Gly His Gly His Ser Pro Gly Leu His Pro Tyr
            740                 745                 750         
Thr Ala Leu Gln Pro His Leu Pro Cys Ser Pro Gln Tyr Leu Thr His
        755                 760                 765             
Pro Ala His Pro Ala His Pro Met Pro His Met Pro Arg Pro Ala Val
    770                 775                 780                 
Phe Pro Val Pro Ser Ser Ala Tyr Pro Gln Gly Val His Pro Ala Phe
785                 790                 795                 800 
Leu Gly Ala Gln Tyr Pro Tyr Ser Val Thr Pro Pro Ser Leu Ala Ala
                805                 810                 815     
Thr Ala Val Ser Phe Pro Val Pro Ser Met Ala Pro Ile Thr Val His
            820                 825                 830         
Pro Tyr His Thr Glu Pro Gly Leu Pro Leu Pro Thr Ser Val Ala Cys
        835                 840                 845             
Glu Leu Trp Gly Gln Gly Thr Val Ser Ser Val His Pro Ala Ser Thr
    850                 855                 860                 
Phe Pro Ala Ile Gln Gly Ala Ser Leu Pro Ala Leu Thr Thr Gln Pro
865                 870                 875                 880 
Ser Pro Leu Val Ser Gly Gly Phe Pro Pro Pro Glu Glu Glu Thr His
                885                 890                 895     
Ser Gln Pro Val Asn Pro His Ser Leu His His Leu His Ala Ala Tyr
            900                 905                 910         
Arg Val Gly Met Leu Ala Leu Glu Met Leu Gly Arg Arg Ala His Asn
        915                 920                 925             
Asp His Pro Asn Asn Phe Ser Arg Ser Pro Pro Tyr Thr Asp Asp Val
    930                 935                 940                 
Lys Trp Leu Leu Gly Leu Ala Ala Lys Leu Gly Val Asn Tyr Val His
945                 950                 955                 960 
Gln Phe Cys Val Gly Ala Ala Lys Gly Val Leu Ser Pro Phe Val Leu
                965                 970                 975     
Gln Glu Ile Val Met Glu Thr Leu Gln Arg Leu Ser Pro Ala His Ala
            980                 985                 990         
His Asn His Leu Arg Ala Pro Ala Phe His Gln Leu Val Gln Arg Cys
        995                 1000                1005            
Gln Gln Ala Tyr Met Gln Tyr Ile His His Ser Leu Ile His Leu Thr
    1010                1015                1020                
Pro Ala Asp Tyr Asp Asp Phe Val Asn Ala Ile Arg Ser Ala Arg Ser
1025                1030                1035                1040
Ala Phe Cys Leu Thr Pro Met Gly Met Met Gln Phe Asn Asp Ile Leu
                1045                1050                1055    
Gln Asn Leu Lys Arg Ser Lys Gln Thr Lys Glu Leu Trp Gln Arg Val
            1060                1065                1070        
Ser Leu Glu Met Ala Thr Phe Ser Pro
        1075                1080    


<210> 1056
<211> 774
<212> PRT
<213> Homo sapiens

<400> 1056
Met Met Ile Leu Tyr Cys Thr Leu Leu Ala Ser Ala Gln Ser Glu Ala
 1               5                  10                  15      
Glu Lys Glu Arg Ile Met Gly Lys Met Glu Ala Asp Pro Glu Leu Ser
            20                  25                  30          
Lys Phe Leu Tyr Gln Leu His Glu Thr Glu Lys Glu Asp Leu Ile Arg
        35                  40                  45              
Glu Glu Arg Ser Arg Arg Glu Arg Val Arg Gln Ser Arg Met Asp Thr
    50                  55                  60                  
Asp Leu Glu Thr Met Asp Leu Asp Gln Gly Gly Glu Ala Leu Ala Pro
65                  70                  75                  80  
Arg Gln Val Leu Asp Leu Glu Asp Leu Val Phe Thr Gln Gly Ser His
                85                  90                  95      
Phe Met Ala Asn Lys Arg Cys Gln Leu Pro Asp Gly Ser Phe Arg Arg
            100                 105                 110         
Gln Arg Lys Gly Tyr Glu Glu Val His Val Pro Ala Leu Lys Pro Lys
        115                 120                 125             
Pro Phe Gly Ser Glu Glu Gln Leu Leu Pro Val Glu Lys Leu Pro Lys
    130                 135                 140                 
Tyr Ala Gln Ala Gly Phe Glu Gly Phe Lys Thr Leu Asn Arg Ile Gln
145                 150                 155                 160 
Ser Lys Leu Tyr Arg Ala Ala Leu Glu Thr Ala Glu Asn Leu Leu Leu
                165                 170                 175     
Cys Ala Pro Thr Gly Ala Gly Lys Thr Asn Val Ala Leu Met Cys Met
            180                 185                 190         
Leu Arg Glu Ile Gly Lys His Ile Asn Met Asp Gly Thr Ile Asn Val
        195                 200                 205             
Asp Asp Phe Lys Ile Ile Tyr Ile Ala Pro Met Arg Ser Leu Val Gln
    210                 215                 220                 
Glu Met Val Gly Ser Phe Gly Lys Arg Leu Ala Thr Tyr Gly Ile Thr
225                 230                 235                 240 
Val Ala Glu Leu Thr Gly Asp His Gln Leu Ser Lys Glu Glu Ile Ser
                245                 250                 255     
Ala Thr Gln Ile Ile Val Cys Thr Pro Glu Lys Trp Asp Ile Ile Thr
            260                 265                 270         
Arg Lys Gly Gly Glu Arg Thr Tyr Thr Gln Leu Val Arg Leu Ile Ile
        275                 280                 285             
Leu Asp Glu Ile His Leu Leu His Asp Asp Arg Gly Pro Val Leu Glu
    290                 295                 300                 
Ala Leu Val Ala Arg Ala Ile Arg Asn Ile Glu Met Thr Gln Glu Asp
305                 310                 315                 320 
Val Arg Leu Ile Gly Leu Ser Ala Thr Leu Pro Asn Tyr Glu Asp Val
                325                 330                 335     
Ala Thr Phe Leu Arg Val Asp Pro Ala Lys Gly Leu Phe Tyr Phe Asp
            340                 345                 350         
Asn Ser Phe Arg Pro Val Pro Leu Glu Arg Thr Tyr Val Gly Ile Thr
        355                 360                 365             
Glu Lys Lys Ala Ile Lys Arg Phe Gln Ile Met Asn Glu Ile Val Tyr
    370                 375                 380                 
Glu Lys Ile Met Glu His Ala Gly Lys Asn Gln Val Leu Val Phe Val
385                 390                 395                 400 
His Ser Arg Lys Glu Thr Gly Lys Thr Ala Arg Ala Ile Arg Asp Met
                405                 410                 415     
Cys Leu Glu Lys Asp Thr Leu Gly Leu Phe Leu Arg Glu Gly Ser Ala
            420                 425                 430         
Ser Thr Glu Val Leu Arg Thr Glu Ala Glu Gln Cys Lys Asn Leu Glu
        435                 440                 445             
Leu Lys Asp Leu Leu Leu Tyr Gly Phe Ala Ile His His Ala Gly Met
    450                 455                 460                 
Thr Arg Val Asp Arg Thr Leu Val Glu Asp Leu Phe Ala Asp Lys His
465                 470                 475                 480 
Ile Gln Val Leu Val Ser Thr Ala Thr Leu Ala Trp Gly Val Asn Leu
                485                 490                 495     
Pro Ala His Thr Val Ile Ile Lys Gly Thr Gln Val Tyr Ser Pro Glu
            500                 505                 510         
Lys Gly Arg Trp Thr Glu Leu Gly Ala Leu Asp Ile Leu Gln Met Leu
        515                 520                 525             
Gly Arg Ala Gly Arg Pro Gln Tyr Asp Thr Lys Gly Glu Gly Ile Leu
    530                 535                 540                 
Ile Thr Ser His Gly Glu Leu Gln Tyr Tyr Leu Ser Leu Leu Asn Gln
545                 550                 555                 560 
Gln Leu Pro Ile Glu Ser Gln Met Val Ser Lys Leu Pro Asp Met Leu
                565                 570                 575     
Asn Ala Glu Ile Val Leu Gly Asn Val Gln Asn Ala Lys Asp Ala Val
            580                 585                 590         
Asn Trp Leu Gly Tyr Ala Tyr Leu Tyr Ile Arg Met Leu Arg Ser Pro
        595                 600                 605             
Thr Leu Tyr Gly Ile Ser His Asp Asp Leu Lys Gly Asp Pro Leu Leu
    610                 615                 620                 
Asp Gln Arg Arg Leu Asp Leu Val His Thr Ala Ala Leu Met Leu Asp
625                 630                 635                 640 
Lys Asn Asn Leu Val Lys Tyr Asp Lys Lys Thr Gly Asn Phe Gln Val
                645                 650                 655     
Thr Glu Leu Gly Arg Ile Ala Ser His Tyr Tyr Ile Thr Asn Asp Thr
            660                 665                 670         
Val Gln Thr Tyr Asn Gln Leu Leu Lys Pro Ser Leu Ser Glu Ile Glu
        675                 680                 685             
Leu Phe Arg Val Phe Ser Leu Ser Ser Glu Phe Lys Asn Ile Thr Val
    690                 695                 700                 
Arg Glu Val Glu Lys Leu Glu Leu Gln Lys Leu Leu Glu Arg Val Pro
705                 710                 715                 720 
Ile Pro Val Lys Glu Ser Ile Glu Glu Pro Ser Ala Lys Ile Asn Val
                725                 730                 735     
Leu Leu Gln Ala Phe Ile Ser Gln Leu Lys Leu Glu Gly Phe Ala Leu
            740                 745                 750         
Met Ala Asp Met Val Tyr Val Thr Gln Ser Ala Gly Arg Leu Met Arg
        755                 760                 765             
Ala Ile Leu Lys Leu Ser
    770                 


<210> 1057
<211> 807
<212> PRT
<213> Homo sapiens

<400> 1057
Met Leu Phe Ile Pro Ser Arg Gln Thr Val Pro Thr Tyr Lys Lys Leu
 1               5                  10                  15      
Pro Glu Asn Val Gln Pro Arg Phe Leu Glu Asp Glu Gly Leu Tyr Thr
            20                  25                  30          
Gly Val Arg Pro Glu Val Ala Arg Thr Asn Gln Asn Ile Met Glu Asn
        35                  40                  45              
Arg Leu Leu Met Gln Asp Pro Glu Arg Arg Trp Phe Gly Asp Asp Gly
    50                  55                  60                  
Arg Ile Leu Ala Leu Pro Asn Pro Ile Lys Pro Phe Pro Ser Arg Pro
65                  70                  75                  80  
Pro Val Leu Thr Gln Glu Gln Ser Ile Lys Ala Glu Leu Glu Thr Leu
                85                  90                  95      
Tyr Lys Lys Ala Val Lys Tyr Val His Ser Ser Gln His Val Ile Arg
            100                 105                 110         
Ser Gly Asp Pro Pro Gly Asn Phe Gln Leu Asp Ile Asp Ile Ser Gly
        115                 120                 125             
Leu Ile Phe Thr His His Pro Cys Phe Ser Arg Glu His Val Leu Ala
    130                 135                 140                 
Ala Lys Leu Ala Gln Leu Tyr Asp Gln Tyr Leu Ala Arg His Gln Arg
145                 150                 155                 160 
Asn Lys Ala Lys Phe Leu Thr Asp Lys Leu Gln Ala Leu Arg Asn Ala
                165                 170                 175     
Val Gln Thr Gly Leu Asp Pro Glu Lys Pro His Gln Ser Leu Asp Thr
            180                 185                 190         
Ile Gln Lys Thr Ile Asn Glu Tyr Lys Ser Glu Ile Arg Gln Thr Arg
        195                 200                 205             
Lys Phe Arg Asp Ala Glu Gln Glu Lys Asp Arg Thr Leu Leu Lys Thr
    210                 215                 220                 
Ile Ile Lys Val Trp Lys Glu Met Lys Ser Leu Arg Glu Phe Gln Arg
225                 230                 235                 240 
Phe Thr Asn Thr Pro Leu Lys Leu Val Leu Arg Lys Glu Lys Ala Asp
                245                 250                 255     
Gln Lys Ala Asp Glu Glu Ala Tyr Glu Ala Glu Ile Gln Ala Glu Ile
            260                 265                 270         
Ser Glu Leu Leu Glu Glu His Thr Glu Glu Tyr Ala Gln Lys Met Glu
        275                 280                 285             
Glu Tyr Arg Thr Ser Leu Gln Gln Trp Lys Ala Trp Arg Lys Val Gln
    290                 295                 300                 
Arg Ala Lys Lys Lys Lys Arg Lys Gln Ala Ala Glu Glu His Pro Gly
305                 310                 315                 320 
Asp Glu Ile Ala Glu Pro Tyr Pro Glu Glu Asp Leu Val Lys Pro Ser
                325                 330                 335     
Pro Pro Glu Pro Thr Asp Arg Ala Val Ile Glu Gln Glu Val Arg Glu
            340                 345                 350         
Arg Ala Ala Gln Ser Arg Arg Arg Pro Trp Glu Pro Thr Leu Val Pro
        355                 360                 365             
Glu Leu Ser Leu Ala Gly Ser Val Thr Pro Asn Asp Gln Cys Pro Arg
    370                 375                 380                 
Ala Glu Val Ser Arg Arg Glu Asp Val Lys Lys Arg Ser Val Tyr Leu
385                 390                 395                 400 
Lys Val Leu Phe Asn Asn Lys Glu Val Ser Arg Thr Val Ser Arg Pro
                405                 410                 415     
Leu Gly Ala Asp Phe Arg Val His Phe Gly Gln Ile Phe Asn Leu Gln
            420                 425                 430         
Ile Val Asn Trp Pro Glu Ser Leu Thr Leu Gln Val Tyr Glu Thr Val
        435                 440                 445             
Gly His Ser Ser Pro Thr Leu Leu Ala Glu Val Phe Leu Pro Ile Pro
    450                 455                 460                 
Glu Thr Thr Val Val Thr Gly Arg Ala Pro Thr Glu Glu Val Glu Phe
465                 470                 475                 480 
Ser Ser Asn Gln His Val Thr Leu Asp His Glu Gly Val Gly Ser Gly
                485                 490                 495     
Val Pro Phe Ser Phe Glu Ala Asp Gly Ser Asn Gln Leu Thr Leu Met
            500                 505                 510         
Thr Ser Gly Lys Val Ser His Ser Val Ala Trp Ala Ile Gly Glu Asn
        515                 520                 525             
Gly Ile Pro Leu Ile Pro Pro Leu Ser Gln Gln Asn Ile Gly Phe Arg
    530                 535                 540                 
Ser Ala Leu Lys Lys Ala Asp Ala Ile Ser Ser Ile Gly Thr Ser Gly
545                 550                 555                 560 
Leu Thr Asp Met Lys Lys Leu Ala Lys Trp Ala Ala Glu Ser Lys Leu
                565                 570                 575     
Asp Pro Asn Asp Pro Asn Asn Ala Pro Leu Met Gln Leu Ile Ser Val
            580                 585                 590         
Ala Thr Ser Gly Glu Ser Tyr Val Pro Asp Phe Phe Arg Leu Glu Gln
        595                 600                 605             
Leu Gln Gln Glu Phe Asn Phe Val Ser Asp Gln Glu Leu Asn Arg Ser
    610                 615                 620                 
Lys Arg Phe Arg Leu Leu His Leu Arg Ser Gln Glu Val Pro Glu Phe
625                 630                 635                 640 
Arg Asn Tyr Lys Gln Val Pro Val Tyr Asp Arg Glu Ile Met Glu Lys
                645                 650                 655     
Val Phe Gln Asp Tyr Glu Lys Arg Leu Arg Asp Arg Asn Val Ile Glu
            660                 665                 670         
Thr Lys Glu His Ile Asp Thr His Arg Ala Ile Val Ala Lys Tyr Leu
        675                 680                 685             
Gln Gln Val Arg Glu Ser Val Met Asp Trp Arg Pro Arg His Leu Thr
    690                 695                 700                 
Arg Trp Asn Arg Tyr Cys Thr Ser Thr Leu Arg His Phe Leu Pro Leu
705                 710                 715                 720 
Leu Glu Lys Ser Gln Gly Glu Asp Val Glu Asp Asp His Arg Ala Glu
                725                 730                 735     
Leu Leu Lys Gln Leu Gly Asp Tyr Arg Phe Ser Gly Phe Pro Leu His
            740                 745                 750         
Met Pro Tyr Ser Glu Val Lys Pro Leu Ile Asp Ala Val Tyr Ser Thr
        755                 760                 765             
Gly Val His Asn Ile Asp Val Pro Asn Val Glu Phe Ala Leu Ala Val
    770                 775                 780                 
Tyr Ile His Pro Tyr Pro Lys Asn Val Leu Ser Val Trp Ile Tyr Val
785                 790                 795                 800 
Ala Ser Leu Ile Arg Asn Arg
                805         


<210> 1058
<211> 705
<212> PRT
<213> Homo sapiens

<400> 1058
Met Asp Ala Asp Lys Glu Lys Asp Leu Gln Lys Phe Leu Lys Asn Val
 1               5                  10                  15      
Asp Glu Ile Ser Asn Leu Ile Gln Glu Met Asn Ser Asp Asp Pro Val
            20                  25                  30          
Val Gln Gln Lys Ala Val Leu Glu Thr Glu Lys Arg Leu Leu Leu Met
        35                  40                  45              
Glu Glu Asp Gln Glu Glu Asp Glu Cys Arg Thr Thr Leu Asn Lys Thr
    50                  55                  60                  
Met Ile Ser Pro Pro Gln Thr Ala Leu Lys Ser Ala Glu Glu Ile Asn
65                  70                  75                  80  
Ser Glu Ala Phe Leu Ala Ser Val Glu Lys Asp Ala Lys Glu Arg Ala
                85                  90                  95      
Lys Arg Arg Arg Glu Asn Lys Val Leu Ala Asp Ala Leu Lys Glu Lys
            100                 105                 110         
Gly Asn Glu Ala Phe Ala Glu Gly Asn Tyr Glu Thr Ala Ile Leu Arg
        115                 120                 125             
Tyr Ser Glu Gly Leu Glu Lys Leu Lys Asp Met Lys Val Leu Tyr Thr
    130                 135                 140                 
Asn Arg Ala Gln Ala Tyr Met Lys Leu Glu Asp Tyr Glu Lys Ala Leu
145                 150                 155                 160 
Val Asp Cys Glu Trp Ala Leu Lys Cys Asp Glu Lys Cys Thr Lys Ala
                165                 170                 175     
Tyr Phe His Met Gly Lys Ala Asn Leu Ala Leu Lys Asn Tyr Ser Val
            180                 185                 190         
Ser Arg Glu Cys Tyr Lys Lys Ile Leu Glu Ile Asn Pro Lys Leu Gln
        195                 200                 205             
Thr Gln Val Lys Gly Tyr Leu Asn Gln Val Asp Leu Gln Glu Lys Ala
    210                 215                 220                 
Asp Leu Gln Glu Lys Glu Ala His Glu Leu Leu Asp Ser Gly Lys Asn
225                 230                 235                 240 
Thr Ala Val Thr Thr Lys Asn Leu Leu Glu Thr Leu Ser Lys Pro Asp
                245                 250                 255     
Gln Ile Pro Leu Phe Tyr Ala Gly Gly Ile Glu Ile Leu Thr Glu Met
            260                 265                 270         
Ile Asn Glu Cys Thr Glu Gln Thr Leu Phe Arg Met His Asn Gly Phe
        275                 280                 285             
Ser Ile Ile Ser Asp Asn Glu Val Ile Arg Arg Cys Phe Ser Thr Ala
    290                 295                 300                 
Gly Asn Asp Ala Val Glu Glu Met Val Cys Val Ser Val Leu Lys Leu
305                 310                 315                 320 
Trp Gln Ala Val Cys Ser Arg Asn Glu Glu Asn Gln Arg Val Leu Val
                325                 330                 335     
Ile His His Asp Arg Ala Arg Leu Leu Ala Ala Leu Leu Ser Ser Lys
            340                 345                 350         
Val Leu Ala Ile Arg Gln Gln Ser Phe Ala Leu Leu Leu His Leu Ala
        355                 360                 365             
Gln Thr Glu Ser Gly Arg Ser Leu Ile Ile Asn His Leu Asp Leu Thr
    370                 375                 380                 
Arg Leu Leu Glu Ala Leu Val Ser Phe Leu Asp Phe Ser Asp Lys Glu
385                 390                 395                 400 
Ala Asn Thr Ala Met Gly Leu Phe Thr Asp Leu Ala Leu Glu Glu Arg
                405                 410                 415     
Phe Gln Val Trp Phe Gln Ala Asn Leu Pro Gly Val Leu Pro Ala Leu
            420                 425                 430         
Thr Gly Val Leu Lys Thr Asp Pro Lys Val Ser Ser Ser Ser Ala Leu
        435                 440                 445             
Cys Gln Cys Ile Ala Ile Met Gly Asn Leu Ser Ala Glu Pro Thr Thr
    450                 455                 460                 
Arg Arg His Met Ala Ala Cys Glu Glu Phe Gly Asp Gly Cys Leu Ser
465                 470                 475                 480 
Leu Leu Ala Arg Cys Glu Glu Asp Val Asp Leu Phe Arg Glu Val Ile
                485                 490                 495     
Tyr Thr Leu Leu Gly Leu Met Met Asn Leu Cys Leu Gln Ala Pro Phe
            500                 505                 510         
Val Ser Glu Val Trp Ala Val Glu Val Ser Arg Arg Cys Leu Ser Leu
        515                 520                 525             
Leu Asn Ser Gln Asp Gly Gly Ile Leu Thr Arg Ala Ala Gly Val Leu
    530                 535                 540                 
Ser Arg Thr Leu Ser Ser Ser Leu Lys Ile Val Glu Glu Ala Leu Arg
545                 550                 555                 560 
Ala Gly Val Val Lys Lys Met Met Lys Phe Leu Lys Thr Gly Gly Glu
                565                 570                 575     
Thr Ala Ser Arg Tyr Ala Ile Lys Ile Leu Ala Ile Cys Thr Asn Ser
            580                 585                 590         
Tyr His Glu Ala Arg Glu Glu Val Ile Arg Leu Asp Lys Lys Leu Ser
        595                 600                 605             
Val Met Met Lys Leu Leu Ser Ser Glu Asp Glu Val Leu Val Gly Asn
    610                 615                 620                 
Ala Ala Leu Cys Leu Gly Asn Cys Met Glu Val Pro Asn Val Ala Ser
625                 630                 635                 640 
Ser Leu Leu Lys Thr Asp Leu Leu Gln Val Leu Leu Lys Leu Ala Gly
                645                 650                 655     
Ser Asp Thr Gln Lys Thr Ala Val Gln Val Asn Ala Gly Ile Ala Leu
            660                 665                 670         
Gly Lys Leu Cys Thr Ala Glu Pro Arg Phe Ala Ala Gln Leu Arg Lys
        675                 680                 685             
Leu His Gly Leu Glu Ile Leu Asn Ser Thr Met Lys Tyr Ile Ser Asp
    690                 695                 700                 
Ser
705 


<210> 1059
<211> 621
<212> PRT
<213> Homo sapiens

<400> 1059
Met Ser Gly Cys Gly Leu Phe Leu Arg Thr Thr Ala Ala Ala Arg Ala
 1               5                  10                  15      
Cys Arg Gly Leu Val Val Ser Thr Ala Asn Arg Arg Leu Leu Arg Thr
            20                  25                  30          
Ser Pro Pro Val Arg Ala Phe Ala Lys Glu Leu Phe Leu Gly Lys Ile
        35                  40                  45              
Lys Lys Lys Glu Val Phe Pro Phe Pro Glu Val Ser Gln Asp Glu Leu
    50                  55                  60                  
Asn Glu Ile Asn Gln Phe Leu Gly Pro Val Glu Lys Phe Phe Thr Glu
65                  70                  75                  80  
Glu Val Asp Ser Arg Lys Ile Asp Gln Glu Gly Lys Ile Pro Asp Glu
                85                  90                  95      
Thr Leu Glu Lys Leu Lys Ser Leu Gly Leu Phe Gly Leu Gln Val Pro
            100                 105                 110         
Glu Glu Tyr Gly Gly Leu Gly Phe Ser Asn Thr Met Tyr Ser Arg Leu
        115                 120                 125             
Gly Glu Ile Ile Ser Met Asp Gly Ser Ile Thr Val Thr Leu Ala Ala
    130                 135                 140                 
His Gln Ala Ile Gly Leu Lys Gly Ile Ile Leu Ala Gly Thr Glu Glu
145                 150                 155                 160 
Gln Lys Ala Lys Tyr Leu Pro Lys Leu Ala Ser Gly Glu His Ile Ala
                165                 170                 175     
Ala Phe Cys Leu Thr Glu Pro Ala Ser Gly Ser Asp Ala Ala Ser Ile
            180                 185                 190         
Arg Ser Arg Ala Thr Leu Ser Glu Asp Lys Lys His Tyr Ile Leu Asn
        195                 200                 205             
Gly Ser Lys Val Trp Ile Thr Asn Gly Gly Leu Ala Asn Ile Phe Thr
    210                 215                 220                 
Val Phe Ala Lys Thr Glu Val Val Asp Ser Asp Gly Ser Val Lys Asp
225                 230                 235                 240 
Lys Ile Thr Ala Phe Ile Val Glu Arg Asp Phe Gly Gly Val Thr Asn
                245                 250                 255     
Gly Lys Pro Glu Asp Lys Leu Gly Ile Arg Gly Ser Asn Thr Cys Glu
            260                 265                 270         
Val His Phe Glu Asn Thr Lys Ile Pro Val Glu Asn Ile Leu Gly Glu
        275                 280                 285             
Val Gly Asp Gly Phe Lys Val Ala Met Asn Ile Leu Asn Ser Gly Arg
    290                 295                 300                 
Phe Ser Met Gly Ser Val Val Ala Gly Leu Leu Lys Arg Leu Ile Glu
305                 310                 315                 320 
Met Thr Ala Glu Tyr Ala Cys Thr Arg Lys Gln Phe Asn Lys Arg Leu
                325                 330                 335     
Ser Glu Phe Gly Leu Ile Gln Glu Lys Phe Ala Leu Met Ala Gln Lys
            340                 345                 350         
Ala Tyr Val Met Glu Ser Met Thr Tyr Leu Thr Ala Gly Met Leu Asp
        355                 360                 365             
Gln Pro Gly Phe Pro Asp Cys Ser Ile Glu Ala Ala Met Val Lys Val
    370                 375                 380                 
Phe Ser Ser Glu Ala Ala Trp Gln Cys Val Ser Glu Ala Leu Gln Ile
385                 390                 395                 400 
Leu Gly Gly Leu Gly Tyr Thr Arg Asp Tyr Pro Tyr Glu Arg Ile Leu
                405                 410                 415     
Arg Asp Thr Arg Ile Leu Leu Ile Phe Glu Gly Thr Asn Glu Ile Leu
            420                 425                 430         
Arg Met Tyr Ile Ala Leu Thr Gly Leu Gln His Ala Gly Arg Ile Leu
        435                 440                 445             
Thr Thr Arg Ile His Glu Leu Lys Gln Ala Lys Val Ser Thr Val Met
    450                 455                 460                 
Asp Thr Val Gly Arg Arg Leu Arg Asp Ser Leu Gly Arg Thr Val Asp
465                 470                 475                 480 
Leu Gly Leu Thr Gly Asn His Gly Val Val His Pro Ser Leu Ala Asp
                485                 490                 495     
Ser Ala Asn Lys Phe Glu Glu Asn Thr Tyr Cys Phe Gly Arg Thr Val
            500                 505                 510         
Glu Thr Leu Leu Leu Arg Phe Gly Lys Thr Ile Met Glu Glu Gln Leu
        515                 520                 525             
Val Leu Lys Arg Val Ala Asn Ile Leu Ile Asn Leu Tyr Gly Met Thr
    530                 535                 540                 
Ala Val Leu Ser Arg Ala Ser Arg Ser Ile Arg Ile Gly Leu Arg Asn
545                 550                 555                 560 
His Asp His Glu Val Leu Leu Ala Asn Thr Phe Cys Val Glu Ala Tyr
                565                 570                 575     
Leu Gln Asn Leu Phe Ser Leu Ser Gln Leu Asp Lys Tyr Ala Pro Glu
            580                 585                 590         
Asn Leu Asp Glu Gln Ile Lys Lys Val Ser Gln Gln Ile Leu Glu Lys
        595                 600                 605             
Arg Ala Tyr Ile Cys Ala His Pro Leu Asp Arg Thr Cys
    610                 615                 620     


<210> 1060
<211> 247
<212> PRT
<213> Homo sapiens

<400> 1060
Met Leu Val Leu Arg Ser Ala Leu Thr Arg Ala Leu Ala Ser Arg Thr
 1               5                  10                  15      
Leu Ala Pro Gln Met Cys Ser Ser Phe Ala Thr Gly Pro Arg Gln Tyr
            20                  25                  30          
Asp Gly Ile Phe Tyr Glu Phe Arg Ser Tyr Tyr Leu Lys Pro Ser Lys
        35                  40                  45              
Met Asn Glu Phe Leu Glu Asn Phe Glu Lys Asn Ala His Leu Arg Thr
    50                  55                  60                  
Ala His Ser Glu Leu Val Gly Tyr Trp Ser Val Glu Phe Gly Gly Arg
65                  70                  75                  80  
Met Asn Thr Val Phe His Ile Trp Lys Tyr Asp Asn Phe Ala His Arg
                85                  90                  95      
Thr Glu Val Gln Lys Ala Leu Ala Lys Asp Lys Glu Trp Gln Glu Gln
            100                 105                 110         
Phe Leu Ile Pro Asn Leu Ala Leu Ile Asp Lys Gln Glu Ser Glu Ile
        115                 120                 125             
Thr Tyr Leu Val Pro Trp Cys Lys Leu Glu Lys Pro Pro Lys Glu Gly
    130                 135                 140                 
Val Tyr Glu Leu Ala Thr Phe Gln Met Lys Pro Gly Gly Pro Ala Leu
145                 150                 155                 160 
Trp Gly Asp Ala Phe Lys Arg Ala Val His Ala His Val Asn Leu Gly
                165                 170                 175     
Tyr Thr Lys Leu Val Gly Val Phe His Thr Glu Tyr Gly Ala Leu Asn
            180                 185                 190         
Arg Val His Val Leu Trp Trp Asn Glu Ser Ala Asp Ser Arg Ala Ala
        195                 200                 205             
Gly Arg His Lys Ser His Glu Asp Pro Arg Val Val Ala Ala Val Arg
    210                 215                 220                 
Glu Ser Val Asn Tyr Leu Val Ser Gln Gln Asn Met Leu Leu Ile Pro
225                 230                 235                 240 
Thr Ser Phe Ser Pro Leu Lys
                245         


<210> 1061
<211> 332
<212> PRT
<213> Homo sapiens

<400> 1061
Met Ala Ser Gly Leu Val Arg Leu Leu Gln Gln Gly His Arg Cys Leu
 1               5                  10                  15      
Leu Ala Pro Val Ala Pro Lys Leu Val Pro Pro Val Arg Gly Val Lys
            20                  25                  30          
Lys Gly Phe Arg Ala Ala Phe Arg Phe Gln Lys Glu Leu Glu Arg Gln
        35                  40                  45              
Arg Leu Leu Arg Cys Pro Pro Pro Pro Val Arg Arg Ser Glu Lys Pro
    50                  55                  60                  
Asn Trp Asp Tyr His Ala Glu Ile Gln Ala Phe Gly His Arg Leu Gln
65                  70                  75                  80  
Glu Asn Phe Ser Leu Asp Leu Leu Lys Thr Ala Phe Val Asn Ser Cys
                85                  90                  95      
Tyr Ile Lys Ser Glu Glu Ala Lys Arg Gln Gln Leu Gly Ile Glu Lys
            100                 105                 110         
Glu Ala Val Leu Leu Asn Leu Lys Ser Asn Gln Glu Leu Ser Glu Gln
        115                 120                 125             
Gly Thr Ser Phe Ser Gln Thr Cys Leu Thr Gln Phe Leu Glu Asp Glu
    130                 135                 140                 
Tyr Pro Asp Met Pro Thr Glu Gly Ile Lys Asn Leu Val Asp Phe Leu
145                 150                 155                 160 
Thr Gly Glu Glu Val Val Cys His Val Ala Arg Asn Leu Ala Val Glu
                165                 170                 175     
Gln Leu Thr Leu Ser Glu Glu Phe Pro Val Pro Pro Ala Val Leu Gln
            180                 185                 190         
Gln Thr Phe Phe Ala Val Ile Gly Ala Leu Leu Gln Ser Ser Gly Pro
        195                 200                 205             
Glu Arg Thr Ala Leu Phe Ile Arg Asp Phe Leu Ile Thr Gln Met Thr
    210                 215                 220                 
Gly Lys Glu Leu Phe Glu Met Arg Lys Ile Ile Asn Pro Met Gly Leu
225                 230                 235                 240 
Leu Val Glu Glu Leu Lys Lys Arg Asn Val Ser Ala Pro Glu Ser Arg
                245                 250                 255     
Leu Thr Arg Gln Ser Gly Gly Thr Thr Ala Leu Pro Leu Tyr Phe Val
            260                 265                 270         
Gly Leu Tyr Cys Asp Lys Lys Leu Ile Ala Glu Gly Pro Gly Glu Thr
        275                 280                 285             
Val Leu Val Ala Glu Glu Glu Ala Ala Arg Val Ala Leu Arg Lys Leu
    290                 295                 300                 
Tyr Gly Phe Thr Glu Asn Arg Arg Pro Trp Asn Tyr Ser Lys Pro Lys
305                 310                 315                 320 
Glu Thr Leu Arg Ala Glu Lys Ser Ile Thr Ala Ser
                325                 330         


<210> 1062
<211> 429
<212> PRT
<213> Homo sapiens

<400> 1062
Met Lys Glu Phe Leu Gly Glu Asn Tyr Val His Tyr Gly Glu Val Val
 1               5                  10                  15      
Gln Leu Pro Leu Glu Phe Val Lys Gln Leu Cys Leu Lys Ile Gln Ser
            20                  25                  30          
Glu Arg Pro Glu Ser Arg Cys Asp Lys Asp Leu Asp Thr Leu Ser Gly
        35                  40                  45              
Tyr Ala Met Cys Leu Pro Asn Leu Thr Arg Leu Gln Thr Tyr Arg Phe
    50                  55                  60                  
Ala Glu His Arg Pro Ile Leu Cys Val Glu Ile Lys Pro Lys Cys Gly
65                  70                  75                  80  
Phe Ile Pro Phe Ser Ser Asp Val Thr His Glu Met Lys His Lys Val
                85                  90                  95      
Cys Arg Tyr Cys Met His Gln His Leu Lys Val Ala Thr Gly Lys Trp
            100                 105                 110         
Lys Gln Ile Ser Lys Tyr Cys Pro Leu Asp Leu Tyr Ser Gly Asn Lys
        115                 120                 125             
Gln Arg Met His Phe Ala Leu Lys Ser Leu Leu Gln Glu Ala Gln Asn
    130                 135                 140                 
Asn Leu Lys Ile Phe Lys Asn Gly Glu Leu Ile Tyr Gly Cys Lys Asp
145                 150                 155                 160 
Ala Arg Ser Pro Val Ala Asp Trp Ser Glu Leu Ala His His Leu Lys
                165                 170                 175     
Pro Phe Phe Phe Pro Ser Asn Gly Leu Ala Ser Gly Pro His Cys Thr
            180                 185                 190         
Arg Ala Val Ile Arg Glu Leu Val His Ala Ile Thr Arg Val Leu Leu
        195                 200                 205             
Ser Gly Ser Asp Lys Gly Arg Ala Gly Thr Leu Ser Pro Gly Leu Gly
    210                 215                 220                 
Pro Gln Gly Pro Arg Val Cys Glu Ala Ser Pro Phe Ser Arg Ser Leu
225                 230                 235                 240 
Arg Cys Gln Gly Lys Asn Thr Pro Glu Arg Ser Gly Leu Pro Lys Gly
                245                 250                 255     
Cys Leu Leu Tyr Lys Thr Leu Gln Val Gln Met Leu Asp Leu Leu Asp
            260                 265                 270         
Ile Glu Gly Leu Tyr Pro Leu Tyr Asn Arg Val Glu Arg Tyr Leu Glu
        275                 280                 285             
Glu Phe Pro Glu Glu Arg Lys Thr Leu Gln Ile Asp Gly Pro Tyr Asp
    290                 295                 300                 
Glu Ala Phe Tyr Gln Lys Leu Leu Asp Leu Ser Thr Glu Asp Asp Gly
305                 310                 315                 320 
Thr Val Ala Phe Ala Leu Thr Lys Val Gln Gln Tyr Arg Val Ala Met
                325                 330                 335     
Thr Ala Lys Asp Cys Ser Ile Met Ile Ala Leu Ser Pro Cys Leu Gln
            340                 345                 350         
Asp Ala Ser Ser Asp Gln Arg Pro Val Val Pro Ser Ser Arg Ser Arg
        355                 360                 365             
Phe Ala Phe Ser Val Ser Val Leu Asp Leu Asp Leu Lys Pro Tyr Glu
    370                 375                 380                 
Ser Ile Pro His Gln Tyr Lys Leu Asp Gly Lys Ile Val Asn Tyr Tyr
385                 390                 395                 400 
Ser Lys Thr Val Arg Ala Lys Asp Asn Ala Val Met Ser Thr Arg Phe
                405                 410                 415     
Lys Glu Ser Glu Asp Cys Thr Leu Val Leu His Lys Val
            420                 425                 


<210> 1063
<211> 239
<212> PRT
<213> Homo sapiens

<400> 1063
Met Ala Ala Leu Lys Ser Trp Leu Ser Arg Ser Val Thr Ser Phe Phe
 1               5                  10                  15      
Arg Tyr Arg Gln Cys Leu Cys Val Pro Val Val Ala Asn Phe Lys Lys
            20                  25                  30          
Arg Cys Phe Ser Glu Leu Ile Arg Pro Trp His Arg Thr Val Thr Ile
        35                  40                  45              
Gly Phe Gly Val Thr Leu Cys Ala Val Pro Ile Ala Gln Lys Ser Glu
    50                  55                  60                  
Pro His Ser Leu Ser Ser Glu Ala Leu Met Arg Arg Ala Val Ser Leu
65                  70                  75                  80  
Val Thr Asp Ser Thr Ser Thr Phe Leu Ser Gln Thr Thr Tyr Ala Leu
                85                  90                  95      
Ile Glu Ala Ile Thr Glu Tyr Thr Lys Ala Val Tyr Thr Leu Thr Ser
            100                 105                 110         
Leu Tyr Arg Gln Tyr Thr Ser Leu Leu Gly Lys Met Asn Ser Glu Glu
        115                 120                 125             
Glu Asp Glu Val Trp Gln Val Ile Ile Gly Ala Arg Ala Glu Met Thr
    130                 135                 140                 
Ser Lys His Gln Glu Tyr Leu Lys Leu Glu Thr Thr Trp Met Thr Ala
145                 150                 155                 160 
Val Gly Leu Ser Glu Met Ala Ala Glu Ala Ala Tyr Gln Thr Gly Ala
                165                 170                 175     
Asp Gln Ala Ser Ile Thr Ala Arg Asn His Ile Gln Leu Val Lys Leu
            180                 185                 190         
Gln Val Glu Glu Val His Gln Leu Ser Arg Lys Ala Glu Thr Lys Leu
        195                 200                 205             
Ala Glu Ala Gln Ile Glu Glu Leu Arg Gln Lys Thr Gln Glu Glu Gly
    210                 215                 220                 
Glu Glu Arg Ala Glu Ser Glu Gln Glu Ala Tyr Leu Arg Glu Asp
225                 230                 235                 


<210> 1064
<211> 239
<212> PRT
<213> Homo sapiens

<400> 1064
Met Ala Ala Leu Lys Ser Trp Leu Ser Arg Ser Val Thr Ser Phe Phe
 1               5                  10                  15      
Arg Tyr Arg Gln Cys Leu Cys Val Pro Val Val Ala Asn Phe Lys Lys
            20                  25                  30          
Arg Cys Phe Ser Glu Leu Ile Arg Pro Trp His Arg Thr Val Thr Ile
        35                  40                  45              
Gly Phe Gly Val Thr Leu Cys Ala Val Pro Ile Ala Gln Lys Ser Glu
    50                  55                  60                  
Pro His Ser Leu Ser Ser Glu Ala Leu Met Arg Arg Ala Val Ser Leu
65                  70                  75                  80  
Val Thr Asp Ser Thr Ser Thr Phe Leu Ser Gln Thr Thr Tyr Ala Leu
                85                  90                  95      
Ile Glu Ala Ile Thr Glu Tyr Thr Lys Ala Val Tyr Thr Leu Thr Ser
            100                 105                 110         
Leu Tyr Arg Gln Tyr Thr Ser Leu Leu Gly Lys Met Asn Ser Glu Glu
        115                 120                 125             
Glu Asp Glu Val Trp Gln Val Ile Ile Gly Ala Arg Ala Glu Met Thr
    130                 135                 140                 
Ser Lys His Gln Glu Tyr Leu Lys Leu Glu Thr Thr Trp Met Thr Ala
145                 150                 155                 160 
Val Gly Leu Ser Glu Met Ala Ala Glu Ala Ala Tyr Gln Thr Gly Ala
                165                 170                 175     
Asp Gln Ala Ser Ile Thr Ala Arg Asn His Ile Gln Leu Val Lys Leu
            180                 185                 190         
Gln Val Glu Glu Val His Gln Leu Ser Arg Lys Ala Glu Thr Lys Leu
        195                 200                 205             
Ala Glu Ala Gln Ile Glu Glu Leu Arg Gln Lys Thr Gln Glu Glu Gly
    210                 215                 220                 
Glu Glu Arg Ala Glu Ser Glu Gln Glu Ala Tyr Leu Arg Glu Asp
225                 230                 235                 


<210> 1065
<211> 248
<212> PRT
<213> Homo sapiens

<400> 1065
Met Glu Gly Glu Pro Glu Asp Asn Val Tyr Leu Lys Arg Leu Tyr Pro
 1               5                  10                  15      
Arg Gln Ile Tyr Glu Val Glu Lys Ala Val His Leu Leu Lys Lys Phe
            20                  25                  30          
Gln Ile Leu Asp Phe Thr Ser Pro Lys Gln Ser Val Tyr Leu Asp Leu
        35                  40                  45              
Thr Leu Asp Met Ala Leu Gly Lys Lys Lys Asn Val Glu Pro Phe Thr
    50                  55                  60                  
Ser Val Leu Ser Leu Pro Tyr Pro Phe Ala Ser Glu Ile Asn Lys Val
65                  70                  75                  80  
Ala Val Phe Thr Glu Asn Ala Ser Glu Val Lys Ile Ala Glu Glu Asn
                85                  90                  95      
Gly Ala Ala Phe Ala Gly Gly Thr Ser Leu Ile Gln Lys Ile Trp Asp
            100                 105                 110         
Asp Glu Ile Val Ala Asp Phe Tyr Val Ala Val Pro Glu Ile Met Pro
        115                 120                 125             
Glu Leu Asn Arg Leu Arg Lys Lys Leu Asn Lys Lys Tyr Pro Lys Leu
    130                 135                 140                 
Ser Arg Asn Ser Ile Gly Arg Asp Ile Pro Lys Met Leu Glu Leu Phe
145                 150                 155                 160 
Lys Asn Gly His Glu Ile Lys Val Asp Glu Glu Arg Glu Asn Phe Leu
                165                 170                 175     
Gln Thr Lys Ile Ala Thr Leu Asp Met Ser Ser Gly Gln Ile Ala Ala
            180                 185                 190         
Asn Leu Gln Ala Val Ile Asn Glu Val Cys Arg His Arg Pro Leu Asn
        195                 200                 205             
Leu Gly Pro Phe Val Val Arg Ala Phe Leu Arg Ser Ser Thr Ser Glu
    210                 215                 220                 
Gly Leu Leu Leu Lys Ile Asp Pro Leu Leu Pro Lys Glu Val Lys Asn
225                 230                 235                 240 
Glu Glu Ser Glu Lys Glu Asp Ala
                245             


<210> 1066
<211> 366
<212> PRT
<213> Homo sapiens

<400> 1066
Met Ala Val Leu Ala Leu Thr Asp Ser Leu Ala Asp Met Lys Ala Arg
 1               5                  10                  15      
Leu Gly Arg Met Val Val Ala Ser Asp Lys Ser Gly Gln Pro Val Thr
            20                  25                  30          
Ala Asp Asp Leu Gly Val Thr Gly Ala Leu Thr Val Leu Met Lys Asp
        35                  40                  45              
Ala Ile Lys Pro Asn Leu Met Gln Thr Leu Glu Gly Thr Pro Val Phe
    50                  55                  60                  
Val His Ala Gly Pro Phe Ala Asn Ile Ala His Gly Asn Ser Ser Val
65                  70                  75                  80  
Leu Ala Asp Lys Ile Ala Leu Lys Leu Val Gly Glu Glu Gly Phe Val
                85                  90                  95      
Val Thr Glu Ala Gly Phe Gly Ala Asp Ile Gly Met Glu Lys Phe Phe
            100                 105                 110         
Asn Ile Lys Cys Arg Ala Ser Gly Leu Val Pro Asn Val Val Val Leu
        115                 120                 125             
Val Ala Thr Val Arg Ala Leu Lys Met His Gly Gly Gly Pro Ser Val
    130                 135                 140                 
Thr Ala Gly Val Pro Leu Lys Lys Glu Tyr Thr Glu Glu Asn Ile Gln
145                 150                 155                 160 
Leu Val Ala Asp Gly Cys Cys Asn Leu Gln Lys Gln Ile Gln Ile Thr
                165                 170                 175     
Gln Leu Phe Gly Val Pro Val Val Val Ala Leu Asn Val Phe Lys Thr
            180                 185                 190         
Asp Thr Arg Ala Glu Ile Asp Leu Val Cys Glu Leu Ala Lys Arg Ala
        195                 200                 205             
Gly Ala Phe Asp Ala Val Pro Cys Tyr His Trp Ser Val Gly Gly Lys
    210                 215                 220                 
Gly Ser Val Asp Leu Ala Arg Ala Val Arg Glu Ala Ala Ser Lys Arg
225                 230                 235                 240 
Ser Arg Phe Gln Phe Leu Tyr Asp Val Gln Val Pro Ile Val Asp Lys
                245                 250                 255     
Ile Met Thr Ile Ala Gln Ala Val Tyr Gly Ala Lys Asp Ile Glu Leu
            260                 265                 270         
Ser Pro Glu Ala Gln Ala Lys Ile Asp Arg Tyr Thr Gln Gln Gly Phe
        275                 280                 285             
Gly Asn Leu Pro Ile Cys Met Ala Lys Thr His Leu Ser Leu Ser His
    290                 295                 300                 
Gln Pro Asp Lys Lys Gly Val Pro Arg Asp Phe Ile Leu Pro Ile Ser
305                 310                 315                 320 
Asp Val Arg Ala Ser Ile Gly Ala Gly Phe Ile Tyr Pro Leu Val Gly
                325                 330                 335     
Thr Met Ser Thr Met Pro Gly Leu Pro Thr Arg Pro Cys Phe Tyr Asp
            340                 345                 350         
Ile Asp Leu Asp Thr Glu Thr Glu Gln Val Lys Gly Leu Phe
        355                 360                 365     


<210> 1067
<211> 696
<212> PRT
<213> Homo sapiens

<400> 1067
Met Glu Asn Thr Phe Lys Cys Ser Asp Lys Ala Asp Thr Ser Ser Leu
 1               5                  10                  15      
Ile Ile Asn Asn Lys Leu Ile Cys Asn Glu Thr Val Glu Val Pro Lys
            20                  25                  30          
Asp Ser Lys Ser Lys Ile Cys Ser Glu Arg Lys Arg Val Asn Glu Asn
        35                  40                  45              
Glu Leu Gln Gln Asp Glu Pro Pro Ala Lys Lys Gly Ser Ile His Val
    50                  55                  60                  
Ser Ser Ala Ile Thr Glu Asp Gln Lys Lys Ser Glu Glu Val Arg Pro
65                  70                  75                  80  
Ser Ile Ala Glu Ile Glu Asp Ile Arg Val Leu Gln Glu Asn Asn Glu
                85                  90                  95      
Gly Leu Arg Ala Phe Leu Leu Thr Ile Glu Asn Glu Leu Lys Asn Glu
            100                 105                 110         
Lys Glu Glu Lys Ala Glu Leu Asn Lys Gln Ile Val His Ser Gln Gln
        115                 120                 125             
Glu Leu Ser Leu Ser Glu Lys Lys Asn Leu Thr Leu Ser Lys Glu Val
    130                 135                 140                 
Gln Gln Ile Gln Ser Asn Tyr Asp Ile Ala Ile Ala Glu Leu His Val
145                 150                 155                 160 
Gln Lys Ser Lys Asn Gln Glu Gln Glu Glu Lys Ile Met Lys Leu Ser
                165                 170                 175     
Asn Glu Ile Glu Thr Ala Thr Arg Ser Ile Thr Asn Asn Val Ser Gln
            180                 185                 190         
Ile Lys Leu Met His Thr Lys Ile Asp Glu Leu Arg Thr Leu Asp Ser
        195                 200                 205             
Val Ser Gln Ile Ser Asn Ile Asp Leu Leu Asn Leu Arg Asp Leu Ser
    210                 215                 220                 
Asn Gly Ser Glu Glu Asp Asn Leu Pro Asn Thr Gln Leu Asp Leu Leu
225                 230                 235                 240 
Gly Asn Asp Tyr Leu Val Ser Lys Gln Val Lys Glu Tyr Arg Ile Gln
                245                 250                 255     
Glu Pro Asn Arg Glu Asn Ser Phe His Ser Ser Ile Glu Ala Ile Trp
            260                 265                 270         
Glu Glu Cys Lys Glu Ile Val Lys Ala Ser Ser Lys Lys Ser His Gln
        275                 280                 285             
Ile Glu Glu Leu Glu Gln Gln Ile Glu Lys Leu Gln Ala Glu Val Lys
    290                 295                 300                 
Gly Tyr Lys Asp Glu Asn Asn Arg Leu Lys Glu Arg Glu His Lys Asn
305                 310                 315                 320 
Gln Asp Asp Leu Leu Lys Glu Lys Glu Thr Leu Ile Gln Gln Leu Lys
                325                 330                 335     
Glu Glu Leu Gln Glu Lys Asn Val Thr Leu Asp Val Gln Ile Gln His
            340                 345                 350         
Val Val Glu Gly Lys Arg Ala Leu Ser Glu Leu Thr Gln Gly Val Thr
        355                 360                 365             
Cys Tyr Lys Ala Lys Ile Lys Glu Leu Glu Thr Ile Leu Glu Thr Gln
    370                 375                 380                 
Lys Val Glu Arg Ser His Ser Ala Lys Leu Glu Gln Asp Ile Leu Glu
385                 390                 395                 400 
Lys Glu Ser Ile Ile Leu Lys Leu Glu Arg Asn Leu Lys Glu Phe Gln
                405                 410                 415     
Glu His Leu Gln Asp Ser Val Lys Asn Thr Lys Asp Leu Asn Val Lys
            420                 425                 430         
Glu Leu Lys Leu Lys Glu Glu Ile Thr Gln Leu Thr Asn Asn Leu Gln
        435                 440                 445             
Asp Met Lys His Leu Leu Gln Leu Lys Glu Glu Glu Glu Glu Thr Asn
    450                 455                 460                 
Arg Gln Glu Thr Glu Lys Leu Lys Glu Glu Leu Ser Ala Ser Ser Ala
465                 470                 475                 480 
Arg Thr Gln Asn Leu Lys Ala Asp Leu Gln Arg Lys Glu Glu Asp Tyr
                485                 490                 495     
Ala Asp Leu Lys Glu Lys Leu Thr Asp Ala Lys Lys Gln Ile Lys Gln
            500                 505                 510         
Val Gln Lys Glu Val Ser Val Met Arg Asp Glu Asp Lys Leu Leu Arg
        515                 520                 525             
Ile Lys Ile Asn Glu Leu Glu Lys Lys Lys Asn Gln Cys Ser Gln Glu
    530                 535                 540                 
Leu Asp Met Lys Gln Arg Thr Ile Gln Gln Leu Lys Glu Gln Leu Asn
545                 550                 555                 560 
Asn Gln Lys Val Glu Glu Ala Ile Gln Gln Tyr Glu Arg Ala Cys Lys
                565                 570                 575     
Asp Leu Asn Val Lys Glu Lys Ile Ile Glu Asp Met Arg Met Thr Leu
            580                 585                 590         
Glu Glu Gln Glu Gln Thr Gln Val Glu Gln Asp Gln Val Leu Glu Ala
        595                 600                 605             
Lys Leu Glu Glu Val Glu Arg Leu Ala Thr Glu Leu Glu Lys Trp Lys
    610                 615                 620                 
Glu Lys Cys Asn Asp Leu Glu Thr Lys Asn Asn Gln Arg Ser Asn Lys
625                 630                 635                 640 
Glu His Glu Asn Asn Thr Asp Val Leu Gly Lys Leu Thr Asn Leu Gln
                645                 650                 655     
Asp Glu Leu Gln Glu Ser Glu Gln Lys Tyr Asn Ala Asp Arg Lys Lys
            660                 665                 670         
Trp Leu Glu Glu Lys Met Met Leu Ile Thr Gln Ala Lys Glu Ala Glu
        675                 680                 685             
Asn Ile Arg Lys Lys Lys Lys Lys
    690                 695     


<210> 1068
<211> 1148
<212> PRT
<213> Homo sapiens

<400> 1068
Met Ser Ser Ile Cys Asn Ser Leu Phe Glu Ala Leu Phe Pro Gly Ser
 1               5                  10                  15      
Ser Tyr Ser Thr Arg Phe Ser Ala Leu Thr Ile Leu Gly Ser Ile Ala
            20                  25                  30          
Glu Val Phe His Val Pro Glu Gly Arg Ile Tyr Thr Val Tyr Gln Leu
        35                  40                  45              
Ser His Asp Ile Asp Val Gly Arg Phe Gln Thr Leu Met Glu Cys Phe
    50                  55                  60                  
Thr Ser Thr Phe Glu Asp Val Lys Ile Leu Ala Phe Asp Leu Leu Met
65                  70                  75                  80  
Lys Leu Ser Lys Thr Ala Val His Phe Gln Asp Ser Gly Lys Leu Gln
                85                  90                  95      
Gly Leu Phe Gln Ala Ala Leu Glu Leu Ser Thr Ser Thr Lys Pro Tyr
            100                 105                 110         
Asp Cys Val Thr Ala Ser Tyr Leu Leu Asn Phe Leu Ile Trp Gln Asp
        115                 120                 125             
Ala Leu Pro Ser Ser Leu Ser Ala Tyr Leu Thr Gln Gln Val Ala Cys
    130                 135                 140                 
Asp Asn Gly Asp Arg Pro Ala Ala Val Val Glu Arg Asn Thr Leu Met
145                 150                 155                 160 
Val Ile Lys Cys Leu Met Glu Asn Leu Glu Glu Glu Val Ser Gln Ala
                165                 170                 175     
Glu Asn Ser Leu Leu Gln Ala Ala Ala Ala Phe Pro Met Tyr Gly Arg
            180                 185                 190         
Val His Cys Ile Thr Gly Ala Leu Gln Lys Leu Ser Leu Asn Ser Leu
        195                 200                 205             
Gln Leu Val Ser Glu Trp Arg Pro Val Val Glu Lys Leu Leu Leu Met
    210                 215                 220                 
Ser Tyr Arg Leu Ser Thr Val Val Ser Pro Val Ile Gln Ser Ser Ser
225                 230                 235                 240 
Pro Glu Gly Leu Ile Pro Met Asp Thr Asp Ser Glu Ser Ala Ser Arg
                245                 250                 255     
Leu Gln Met Ile Leu Asn Glu Ile Gln Pro Arg Asp Thr Asn Asp Tyr
            260                 265                 270         
Phe Asn Gln Ala Lys Ile Leu Lys Glu His Asp Ser Phe Asp Met Lys
        275                 280                 285             
Asp Leu Asn Ala Ser Val Val Asn Ile Asp Thr Ser Thr Glu Ile Lys
    290                 295                 300                 
Gly Lys Glu Val Lys Thr Cys Asp Val Thr Ala Gln Met Val Leu Val
305                 310                 315                 320 
Cys Cys Trp Arg Ser Met Lys Glu Val Ala Leu Leu Leu Gly Met Leu
                325                 330                 335     
Cys Gln Leu Leu Pro Met Gln Pro Val Pro Glu Ser Ser Asp Gly Leu
            340                 345                 350         
Leu Thr Val Glu Gln Val Lys Glu Ile Gly Asp Tyr Phe Lys Gln His
        355                 360                 365             
Leu Leu Gln Ser Arg His Arg Gly Ala Phe Glu Leu Ala Tyr Thr Gly
    370                 375                 380                 
Phe Val Lys Leu Thr Glu Val Leu Asn Arg Cys Pro Asn Val Ser Leu
385                 390                 395                 400 
Gln Lys Leu Pro Glu Gln Trp Leu Trp Ser Val Leu Glu Glu Ile Lys
                405                 410                 415     
Cys Ser Asp Pro Ser Ser Lys Leu Cys Ala Thr Arg Arg Ser Ala Gly
            420                 425                 430         
Ile Pro Phe Tyr Ile Gln Ala Leu Leu Ala Ser Glu Pro Lys Lys Gly
        435                 440                 445             
Arg Met Asp Leu Leu Lys Ile Thr Met Lys Glu Leu Ile Ser Leu Ala
    450                 455                 460                 
Gly Pro Thr Asp Asp Ile Gln Ser Thr Val Pro Gln Val His Ala Leu
465                 470                 475                 480 
Asn Ile Leu Arg Ala Leu Phe Arg Asp Thr Arg Leu Gly Glu Asn Ile
                485                 490                 495     
Ile Pro Tyr Val Ala Asp Gly Ala Lys Ala Ala Ile Leu Gly Phe Thr
            500                 505                 510         
Ser Pro Val Trp Ala Val Arg Asn Ser Ser Thr Leu Leu Phe Ser Ala
        515                 520                 525             
Leu Ile Thr Arg Ile Phe Gly Val Lys Arg Ala Lys Asp Glu His Ser
    530                 535                 540                 
Lys Thr Asn Arg Cys Gly His Ser Pro Val Tyr His Ser Arg Glu Met
545                 550                 555                 560 
Ala Ala Arg Ala Leu Val Pro Phe Val Met Ile Asp His Ile Pro Asn
                565                 570                 575     
Thr Ile Arg Thr Leu Leu Ser Thr Leu Pro Ser Cys Thr Asp Gln Cys
            580                 585                 590         
Phe Arg Gln Asn His Ile His Gly Thr Leu Leu Gln Val Phe His Leu
        595                 600                 605             
Leu Gln Ala Tyr Ser Asp Ser Lys His Gly Thr Asn Ser Asp Phe Gln
    610                 615                 620                 
His Glu Leu Thr Asp Ile Thr Val Cys Thr Lys Ala Lys Leu Trp Leu
625                 630                 635                 640 
Ala Lys Arg Gln Asn Pro Cys Leu Val Thr Arg Ala Val Tyr Ile Asp
                645                 650                 655     
Ile Leu Phe Leu Leu Thr Cys Cys Leu Asn Arg Ser Ala Lys Asp Asn
            660                 665                 670         
Gln Pro Val Leu Glu Ser Leu Gly Phe Trp Glu Glu Val Arg Gly Ile
        675                 680                 685             
Ile Ser Gly Ser Glu Leu Ile Thr Gly Phe Pro Trp Ala Leu Lys Val
    690                 695                 700                 
Pro Gly Leu Pro Gln Tyr Leu Gln Ser Leu Thr Arg Leu Ala Ile Ala
705                 710                 715                 720 
Ala Val Trp Ala Ala Ala Ala Lys Ser Gly Glu Arg Glu Thr Asn Val
                725                 730                 735     
Pro Ile Ser Phe Ser Gln Leu Leu Glu Ser Ala Phe Pro Glu Val Arg
            740                 745                 750         
Ser Leu Thr Leu Glu Ala Leu Leu Glu Lys Phe Leu Ala Ala Ala Ser
        755                 760                 765             
Gly Leu Gly Glu Lys Gly Val Pro Pro Leu Leu Cys Asn Met Gly Glu
    770                 775                 780                 
Lys Phe Leu Leu Leu Ala Met Lys Glu Asn His Pro Glu Cys Phe Cys
785                 790                 795                 800 
Lys Ile Leu Lys Ile Leu His Cys Met Asp Pro Gly Glu Trp Leu Pro
                805                 810                 815     
Gln Thr Glu His Cys Val His Leu Thr Pro Lys Glu Phe Leu Ile Trp
            820                 825                 830         
Thr Met Asp Ile Ala Ser Asn Glu Arg Ser Glu Ile Gln Ser Val Ala
        835                 840                 845             
Leu Arg Leu Ala Ser Lys Val Ile Ser His His Met Gln Thr Cys Val
    850                 855                 860                 
Glu Asn Arg Glu Leu Ile Ala Ala Glu Leu Lys Gln Trp Val Gln Leu
865                 870                 875                 880 
Val Ile Leu Ser Cys Glu Asp His Leu Pro Thr Glu Ser Arg Leu Ala
                885                 890                 895     
Val Val Glu Val Leu Thr Ser Ile Thr Pro Leu Phe Leu Thr Asn Pro
            900                 905                 910         
His Pro Ile Leu Glu Leu Gln Asp Thr Leu Ala Leu Trp Lys Cys Val
        915                 920                 925             
Leu Thr Leu Leu Gln Ser Glu Glu Gln Ala Val Arg Asp Ala Ala Thr
    930                 935                 940                 
Glu Thr Val Thr Thr Ala Met Ser Gln Glu Asn Thr Cys Gln Ser Thr
945                 950                 955                 960 
Glu Phe Ala Phe Cys Gln Val Asp Ala Ser Ile Ala Leu Ala Leu Ala
                965                 970                 975     
Leu Ala Val Leu Cys Asp Leu Leu Gln Gln Trp Asp Gln Leu Ala Pro
            980                 985                 990         
Gly Leu Pro Ile Leu Leu Gly Trp Leu Leu Gly Glu Ser Asp Asp Leu
        995                 1000                1005            
Val Ala Cys Val Glu Ser Met His Gln Val Glu Glu Asp Tyr Leu Phe
    1010                1015                1020                
Glu Lys Ala Glu Val Asn Phe Trp Ala Glu Thr Leu Ile Phe Val Lys
1025                1030                1035                1040
Tyr Leu Cys Lys His Leu Phe Cys Leu Leu Ser Lys Ser Gly Trp Arg
                1045                1050                1055    
Pro Pro Ser Pro Glu Met Leu Cys His Leu Gln Arg Met Val Ser Glu
            1060                1065                1070        
Gln Cys His Leu Leu Ser Gln Phe Phe Arg Glu Leu Pro Pro Ala Ala
        1075                1080                1085            
Glu Phe Val Lys Thr Val Glu Phe Thr Arg Leu Arg Ile Gln Glu Glu
    1090                1095                1100                
Arg Thr Leu Ala Cys Leu Arg Leu Leu Ala Phe Leu Glu Gly Lys Glu
1105                1110                1115                1120
Gly Glu Asp Thr Leu Val Leu Ser Val Trp Asp Ser Tyr Ala Glu Ser
                1125                1130                1135    
Arg Gln Leu Thr Leu Pro Arg Thr Glu Ala Ala Cys
            1140                1145            


<210> 1069
<211> 868
<212> PRT
<213> Homo sapiens

<400> 1069
Met Gln Leu His Gly Val Leu Arg Val Ile Leu Glu Pro Leu Ile Gly
 1               5                  10                  15      
Asp Leu Pro Phe Val Gly Ala Val Ser Met Phe Phe Ile Arg Arg Pro
            20                  25                  30          
Thr Leu Asp Ile Asn Trp Thr Gly Met Thr Asn Leu Leu Asp Ile Pro
        35                  40                  45              
Gly Leu Ser Ser Leu Ser Asp Thr Met Ile Met Asp Ser Ile Ala Ala
    50                  55                  60                  
Phe Leu Val Leu Pro Asn Arg Leu Leu Val Pro Leu Val Pro Asp Leu
65                  70                  75                  80  
Gln Asp Val Ala Gln Leu Arg Ser Pro Leu Pro Arg Gly Ile Ile Arg
                85                  90                  95      
Ile His Leu Leu Ala Ala Arg Gly Leu Ser Ser Lys Asp Lys Tyr Val
            100                 105                 110         
Lys Gly Leu Ile Glu Gly Lys Ser Asp Pro Tyr Ala Leu Val Arg Leu
        115                 120                 125             
Gly Thr Gln Thr Phe Cys Ser Arg Val Ile Asp Glu Glu Leu Asn Pro
    130                 135                 140                 
Gln Trp Gly Glu Thr Tyr Glu Val Met Val His Glu Val Pro Gly Gln
145                 150                 155                 160 
Glu Ile Glu Val Glu Val Phe Asp Lys Asp Pro Asp Lys Asp Asp Phe
                165                 170                 175     
Leu Gly Arg Met Lys Leu Asp Val Gly Lys Val Leu Gln Ala Ser Val
            180                 185                 190         
Leu Asp Asp Trp Phe Pro Leu Gln Gly Gly Gln Gly Gln Val His Leu
        195                 200                 205             
Arg Leu Glu Trp Leu Ser Leu Leu Ser Asp Ala Glu Lys Leu Glu Gln
    210                 215                 220                 
Val Leu Gln Trp Asn Trp Gly Val Ser Ser Arg Pro Asp Pro Pro Ser
225                 230                 235                 240 
Ala Ala Ile Leu Val Val Tyr Leu Asp Arg Ala Gln Asn Leu Pro Leu
                245                 250                 255     
Lys Lys Gly Asn Lys Glu Pro Asn Pro Met Val Gln Leu Ser Ile Gln
            260                 265                 270         
Asp Val Thr Gln Glu Ser Lys Ala Val Tyr Ser Thr Asn Cys Pro Val
        275                 280                 285             
Trp Glu Glu Ala Phe Arg Phe Phe Leu Gln Asp Pro Gln Ser Gln Glu
    290                 295                 300                 
Leu Asp Val Gln Val Lys Asp Asp Ser Arg Ala Leu Thr Leu Gly Ala
305                 310                 315                 320 
Leu Thr Leu Pro Leu Ala Arg Leu Leu Thr Ala Pro Glu Leu Ile Leu
                325                 330                 335     
Asp Gln Trp Phe Gln Leu Ser Ser Ser Gly Pro Asn Ser Arg Leu Tyr
            340                 345                 350         
Met Lys Leu Val Met Arg Ile Leu Tyr Leu Asp Ser Ser Glu Ile Cys
        355                 360                 365             
Phe Pro Thr Val Pro Gly Cys Pro Gly Ala Trp Asp Val Asp Ser Glu
    370                 375                 380                 
Asn Pro Gln Arg Gly Ser Ser Val Asp Ala Pro Pro Arg Pro Cys His
385                 390                 395                 400 
Thr Thr Pro Asp Ser Gln Phe Gly Thr Glu His Val Leu Arg Ile His
                405                 410                 415     
Val Leu Glu Ala Gln Asp Leu Ile Ala Lys Asp Arg Phe Leu Gly Gly
            420                 425                 430         
Leu Val Lys Gly Lys Ser Asp Pro Tyr Val Lys Leu Lys Leu Ala Gly
        435                 440                 445             
Arg Ser Phe Arg Ser His Val Val Arg Glu Asp Leu Asn Pro Arg Trp
    450                 455                 460                 
Asn Glu Val Phe Glu Val Ile Val Thr Ser Val Pro Gly Gln Glu Leu
465                 470                 475                 480 
Glu Val Glu Val Phe Asp Lys Asp Leu Asp Lys Asp Asp Phe Leu Gly
                485                 490                 495     
Arg Cys Lys Val Arg Phe Thr Thr Val Leu Asn Ser Gly Phe Leu Asp
            500                 505                 510         
Glu Trp Leu Thr Leu Glu Asp Val Pro Ser Gly Arg Leu His Leu Arg
        515                 520                 525             
Leu Glu Arg Leu Thr Pro Arg Pro Thr Ala Ala Glu Leu Glu Glu Val
    530                 535                 540                 
Leu Gln Val Asn Ser Leu Ile Gln Thr Gln Lys Ser Ala Glu Leu Ala
545                 550                 555                 560 
Ala Ala Leu Leu Ser Ile Tyr Met Glu Arg Ala Glu Asp Leu Pro Leu
                565                 570                 575     
Arg Lys Gly Thr Lys His Leu Ser Pro Tyr Ala Thr Leu Thr Val Gly
            580                 585                 590         
Asp Ser Ser His Lys Thr Lys Thr Ile Ser Gln Thr Ser Ala Pro Val
        595                 600                 605             
Trp Asp Glu Ser Ala Ser Phe Leu Ile Arg Lys Pro His Thr Glu Ser
    610                 615                 620                 
Leu Glu Leu Gln Val Arg Gly Glu Gly Thr Gly Val Leu Gly Ser Leu
625                 630                 635                 640 
Ser Leu Pro Leu Ser Glu Leu Leu Val Ala Asp Gln Leu Cys Leu Asp
                645                 650                 655     
Arg Trp Phe Thr Leu Ser Ser Gly Gln Gly Gln Val Leu Leu Arg Ala
            660                 665                 670         
Gln Leu Gly Ile Leu Val Ser Gln His Ser Gly Val Glu Ala His Ser
        675                 680                 685             
His Ser Tyr Ser His Ser Ser Ser Ser Leu Ser Glu Glu Pro Glu Leu
    690                 695                 700                 
Ser Gly Gly Pro Pro His Ile Thr Ser Ser Ala Pro Glu Leu Arg Gln
705                 710                 715                 720 
Arg Leu Thr His Val Asp Ser Pro Leu Glu Ala Pro Ala Gly Pro Leu
                725                 730                 735     
Gly Gln Val Lys Leu Thr Leu Trp Tyr Tyr Ser Glu Glu Arg Lys Leu
            740                 745                 750         
Val Ser Ile Val His Gly Cys Arg Ser Pro Arg Gln Asn Gly Arg Asp
        755                 760                 765             
Pro Pro Asp Pro Tyr Val Ser Leu Leu Leu Leu Pro Asp Lys Asn Arg
    770                 775                 780                 
Gly Thr Lys Arg Arg Thr Ser Gln Lys Lys Arg Thr Leu Ser Pro Glu
785                 790                 795                 800 
Phe Asn Glu Arg Phe Glu Trp Glu Leu Pro Leu Asp Glu Ala Gln Arg
                805                 810                 815     
Arg Lys Leu Asp Val Ser Val Lys Ser Asn Ser Ser Phe Met Ser Arg
            820                 825                 830         
Glu Arg Glu Leu Leu Gly Lys Val Gln Leu Asp Leu Ala Glu Thr Asp
        835                 840                 845             
Leu Ser Gln Gly Val Ala Arg Trp Tyr Asp Leu Met Asp Asn Lys Asp
    850                 855                 860                 
Lys Gly Ser Ser
865             


<210> 1070
<211> 746
<212> PRT
<213> Homo sapiens

<400> 1070
Met Gly Leu Lys Val Ile Gln Gln Asn Val Arg Lys Phe Leu Gln Leu
 1               5                  10                  15      
Arg Phe Trp Gly Trp Trp Lys Leu Tyr Asn Lys Val Lys Pro Leu Leu
            20                  25                  30          
Asn Val Ala Arg Gln Glu Glu Glu Met Lys Ala Lys Glu Glu Glu Leu
        35                  40                  45              
Arg Lys Ala Met Ala Gln Thr Gln Glu Leu Val Asn Lys Val Lys Glu
    50                  55                  60                  
Leu Glu Glu Lys Thr Ala Thr Leu Ser Gln Glu Lys Asn Asp Leu Thr
65                  70                  75                  80  
Ile Gln Leu Gln Ala Glu Gln Glu Asn Leu Met Asp Ala Glu Glu Arg
                85                  90                  95      
Leu Thr Trp Met Met Lys Thr Lys Met Asp Leu Glu Ser Gln Ile Ser
            100                 105                 110         
Asp Met Arg Glu Arg Leu Glu Glu Glu Glu Gly Met Ala Ala Ser Leu
        115                 120                 125             
Ser Ala Ala Lys Arg Lys Leu Glu Gly Glu Leu Ser Asp Leu Lys Arg
    130                 135                 140                 
Asp Leu Glu Gly Leu Glu Thr Thr Leu Ala Lys Thr Glu Lys Glu Lys
145                 150                 155                 160 
Gln Ala Leu Asp His Lys Val Arg Thr Leu Thr Gly Asp Leu Ser Leu
                165                 170                 175     
Arg Glu Asp Ser Ile Thr Lys Leu Gln Lys Glu Lys Arg Ala Leu Glu
            180                 185                 190         
Glu Leu His Gln Lys Thr Leu Asp Asp Leu Gln Ala Glu Glu Asp Lys
        195                 200                 205             
Val Asn His Leu Thr Lys Asn Asn Ser Lys Leu Ser Thr Gln Ile His
    210                 215                 220                 
Glu Leu Glu Asp Asn Trp Glu Gln Glu Lys Lys Ile Arg Ala Glu Val
225                 230                 235                 240 
Glu Lys Ala Arg Arg Lys Ala Glu Ser Asp Leu Lys Met Thr Ile Asp
                245                 250                 255     
Asn Leu Asn Glu Met Glu Arg Ser Lys Leu Asp Leu Glu Glu Val Val
            260                 265                 270         
Lys Lys Arg Asp Leu Glu Ile Asn Ser Val Asn Ser Lys Tyr Glu Asp
        275                 280                 285             
Glu Gln Ser Leu Asn Ser Thr Leu Gln Arg Lys Leu Lys Glu His Gln
    290                 295                 300                 
Asp Arg Ile Glu Glu Leu Glu Glu Glu Leu Glu Ala Glu Arg Ala Met
305                 310                 315                 320 
Arg Ala Lys Ile Glu Gln Asn Arg Lys Arg Glu Ala Glu Leu Leu Lys
                325                 330                 335     
Leu Arg Arg Glu Leu Glu Glu Ala Ala Leu Gln Ser Glu Ala Thr Ala
            340                 345                 350         
Ser Thr Leu Arg Lys Lys His Val Asp Ser Met Ala Glu Leu Thr Glu
        355                 360                 365             
His Val Glu Ser Leu Gln Arg Val Lys Ser Lys Leu Glu Lys Asp Lys
    370                 375                 380                 
Gln Val Met Lys Ala Glu Ile Asp Asp Leu Asn Ala Ser Met Glu Thr
385                 390                 395                 400 
Ile Gln Lys Ser Lys Met Asn Ala Glu Ala His Val Arg Lys Leu Glu
                405                 410                 415     
Asp Ser Leu Ser Glu Ala Asn Ala Lys Val Ala Glu Leu Glu Arg Asn
            420                 425                 430         
Gln Ala Glu Ile Asn Ala Ile Arg Thr Arg Leu Gln Ala Glu Asn Ser
        435                 440                 445             
Glu Leu Ser Arg Glu Tyr Glu Glu Ser Gln Ser Arg Leu Asn Gln Ile
    450                 455                 460                 
Leu Arg Ile Lys Thr Ser Leu Thr Ser Gln Val Asp Asp Tyr Lys Arg
465                 470                 475                 480 
Gln Leu Asp Glu Glu Ser Lys Ser Arg Ser Thr Ala Val Val Ser Leu
                485                 490                 495     
Ala Asn Thr Lys His Asp Leu Asp Leu Val Lys Glu Gln Leu Glu Glu
            500                 505                 510         
Glu Gln Gly Gly Lys Ser Glu Leu Gln Arg Leu Val Ser Lys Leu Asn
        515                 520                 525             
Thr Glu Val Thr Thr Trp Arg Thr Lys Tyr Glu Thr Asp Ala Ile Gln
    530                 535                 540                 
Arg Thr Glu Glu Leu Glu Glu Thr Lys Arg Lys Leu Ala Ala Arg Leu
545                 550                 555                 560 
Gln Glu Ala Glu Glu Ala Ala Glu Thr Ala Gln Ala Arg Ala Ala Ser
                565                 570                 575     
Leu Glu Lys Asn Lys Gln Arg Leu Gln Ala Glu Val Glu Asp Leu Thr
            580                 585                 590         
Ile Asp Leu Glu Lys Ala Asn Ala Ala Ala Ala Ala Leu Asp Lys Lys
        595                 600                 605             
Gln Arg Leu Phe Asp Lys Met Leu Ala Glu Trp Gln Gln Lys Cys Glu
    610                 615                 620                 
Glu Leu Gln Val Glu Val Asp Ser Ser Gln Lys Glu Cys Arg Met Tyr
625                 630                 635                 640 
Met Thr Glu Ser Phe Lys Ile Lys Thr Ala Tyr Glu Glu Ser Leu Glu
                645                 650                 655     
His Leu Glu Ser Val Lys Lys Glu Asn Lys Thr Leu Gln Glu Glu Ile
            660                 665                 670         
Lys Asp Leu Ile Asp Gln Leu Gly Glu Gly Gly Arg Ser Val His Glu
        675                 680                 685             
Leu Gln Lys Leu Lys Lys Lys Leu Glu Met Glu Lys Glu Glu Leu Gln
    690                 695                 700                 
Val Ala Leu Glu Glu Ala Glu Ser Ser Leu Glu Val Glu Glu Ser Lys
705                 710                 715                 720 
Val Ile Arg Ile Gln Leu Glu Leu Ala Gln Val Lys Ala Asp Ile Asp
                725                 730                 735     
Arg Arg Ile His Glu Lys Lys Lys Lys Lys
            740                 745     


<210> 1071
<211> 570
<212> PRT
<213> Homo sapiens

<400> 1071
Met Ser Arg Leu Glu Ala Lys Lys Pro Ser Leu Cys Lys Ser Glu Pro
 1               5                  10                  15      
Leu Thr Thr Glu Arg Val Arg Thr Thr Leu Ser Val Leu Lys Arg Ile
            20                  25                  30          
Val Thr Ser Cys Tyr Gly Pro Ser Gly Arg Leu Lys Gln Leu His Asn
        35                  40                  45              
Gly Phe Gly Gly Tyr Val Cys Thr Thr Ser Gln Ser Ser Ala Leu Leu
    50                  55                  60                  
Ser His Leu Leu Val Thr His Pro Ile Leu Lys Ile Leu Thr Ala Ser
65                  70                  75                  80  
Ile Gln Asn His Val Ser Ser Phe Ser Asp Cys Gly Leu Phe Thr Ala
                85                  90                  95      
Ile Leu Cys Cys Asn Leu Ile Glu Asn Val Gln Arg Leu Gly Leu Thr
            100                 105                 110         
Pro Thr Thr Val Ile Arg Leu Asn Lys His Leu Leu Ser Leu Cys Ile
        115                 120                 125             
Ser Tyr Leu Lys Ser Glu Thr Cys Gly Cys Arg Ile Pro Val Asp Phe
    130                 135                 140                 
Ser Ser Thr Gln Ile Leu Leu Cys Leu Val Arg Ser Ile Leu Thr Ser
145                 150                 155                 160 
Lys Pro Ala Cys Met Leu Thr Arg Lys Glu Thr Glu His Val Ser Ala
                165                 170                 175     
Leu Ile Leu Arg Ala Phe Leu Leu Thr Ile Pro Glu Asn Ala Glu Gly
            180                 185                 190         
His Ile Ile Leu Gly Lys Ser Leu Ile Val Pro Leu Lys Gly Gln Arg
        195                 200                 205             
Val Ile Asp Ser Thr Val Leu Pro Gly Ile Leu Ile Glu Met Ser Glu
    210                 215                 220                 
Val Gln Leu Met Arg Leu Leu Pro Ile Lys Lys Ser Thr Ala Leu Lys
225                 230                 235                 240 
Val Ala Leu Phe Cys Thr Thr Leu Ser Gly Asp Thr Ser Asp Thr Gly
                245                 250                 255     
Glu Gly Thr Val Val Val Ser Tyr Gly Val Ser Leu Glu Asn Ala Val
            260                 265                 270         
Ser Asp Gln Leu Leu Asn Leu Gly Arg Gln Leu Ile Ser Asp His Val
        275                 280                 285             
Asp Leu Val Leu Cys Gln Lys Val Ile His Pro Ser Leu Lys Gln Phe
    290                 295                 300                 
Leu Asn Met His Arg Ile Ile Ala Ile Asp Arg Ile Gly Val Thr Leu
305                 310                 315                 320 
Met Glu Pro Leu Thr Lys Met Thr Gly Thr Gln Pro Ile Gly Ser Leu
                325                 330                 335     
Gly Ser Ile Cys Pro Asn Ser Tyr Gly Ser Val Lys Asp Val Cys Thr
            340                 345                 350         
Ala Lys Phe Gly Ser Lys His Phe Phe His Leu Ile Pro Asn Glu Ala
        355                 360                 365             
Thr Ile Cys Ser Leu Leu Leu Cys Asn Arg Asn Asp Thr Ala Trp Asp
    370                 375                 380                 
Glu Leu Lys Leu Thr Cys Gln Thr Ala Leu His Val Leu Gln Leu Thr
385                 390                 395                 400 
Leu Lys Glu Pro Trp Ala Leu Leu Gly Gly Gly Cys Thr Glu Thr His
                405                 410                 415     
Leu Ala Ala Tyr Ile Arg His Lys Thr His Asn Asp Pro Glu Ser Ile
            420                 425                 430         
Leu Lys Asp Asp Glu Cys Thr Gln Thr Glu Leu Gln Leu Ile Ala Glu
        435                 440                 445             
Ala Phe Cys Ser Ala Leu Glu Ser Val Val Gly Ser Leu Glu His Asp
    450                 455                 460                 
Gly Gly Glu Ile Leu Thr Asp Met Lys Tyr Gly His Leu Trp Ser Val
465                 470                 475                 480 
His Ala Asp Ser Pro Cys Val Ala Asn Trp Pro Asp Leu Leu Ser Gln
                485                 490                 495     
Cys Gly Cys Gly Leu Tyr Asn Ser Gln Glu Glu Leu Asn Trp Ser Phe
            500                 505                 510         
Leu Arg Ser Thr Cys Arg Pro Phe Val Pro Gln Ser Cys Phe Pro His
        515                 520                 525             
Glu Ala Val Val Ser Ala Ser Asn Leu Thr Leu Asp Cys Leu Thr Ala
    530                 535                 540                 
Lys Leu Ser Gly Leu Gln Val Ala Val Glu Thr Ala Asn Leu Ile Leu
545                 550                 555                 560 
Asp Leu Ser Tyr Val Ile Glu Asp Lys Asn
                565                 570 


<210> 1072
<211> 669
<212> PRT
<213> Homo sapiens

<400> 1072
Met Ile Ala Thr Val Asp Leu Lys Val Asn Glu Tyr Glu Lys Asn Gln
 1               5                  10                  15      
Lys Trp Leu Glu Ile Leu Asn Lys Ile Glu Asn Lys Thr Tyr Thr Lys
            20                  25                  30          
Leu Lys Asn Gly His Val Phe Arg Lys Gln Ala Leu Met Ser Glu Glu
        35                  40                  45              
Arg Thr Leu Leu Tyr Asp Gly Leu Val Tyr Trp Lys Thr Ala Thr Gly
    50                  55                  60                  
Arg Phe Lys Asp Ile Leu Ala Leu Leu Leu Thr Asp Val Leu Leu Phe
65                  70                  75                  80  
Leu Gln Glu Lys Asp Gln Lys Tyr Ile Phe Ala Ala Val Asp Gln Lys
                85                  90                  95      
Pro Ser Val Ile Ser Leu Gln Lys Leu Ile Ala Arg Glu Val Ala Asn
            100                 105                 110         
Glu Glu Arg Gly Met Phe Leu Ile Ser Ala Ser Ser Ala Gly Pro Glu
        115                 120                 125             
Met Tyr Glu Ile His Thr Asn Ser Lys Glu Glu Arg Asn Asn Trp Met
    130                 135                 140                 
Arg Arg Ile Gln Gln Ala Val Glu Ser Cys Pro Glu Glu Lys Gly Gly
145                 150                 155                 160 
Arg Thr Ser Glu Ser Asp Glu Asp Lys Arg Lys Ala Glu Ala Arg Val
                165                 170                 175     
Ala Lys Ile Gln Gln Cys Gln Glu Ile Leu Thr Asn Gln Asp Gln Gln
            180                 185                 190         
Ile Cys Ala Tyr Leu Glu Glu Lys Leu His Ile Tyr Ala Glu Leu Gly
        195                 200                 205             
Glu Leu Ser Gly Phe Glu Asp Val His Leu Glu Pro His Leu Leu Ile
    210                 215                 220                 
Lys Pro Asp Pro Gly Glu Pro Pro Gln Ala Ala Ser Leu Leu Ala Ala
225                 230                 235                 240 
Ala Leu Lys Glu Ala Glu Ser Leu Gln Val Ala Val Lys Ala Ser Gln
                245                 250                 255     
Met Gly Ala Val Ser Gln Ser Cys Glu Asp Ser Cys Gly Asp Ser Val
            260                 265                 270         
Leu Ala Asp Thr Leu Ser Ser His Asp Val Pro Gly Ser Pro Thr Ala
        275                 280                 285             
Ser Leu Val Thr Gly Gly Arg Glu Gly Arg Gly Cys Ser Asp Val Asp
    290                 295                 300                 
Pro Gly Ile Gln Gly Val Val Thr Asp Leu Ala Val Ser Asp Ala Gly
305                 310                 315                 320 
Glu Lys Val Glu Cys Arg Asn Phe Pro Gly Ser Ser Gln Ser Glu Ile
                325                 330                 335     
Ile Gln Ala Ile Gln Asn Leu Thr Arg Leu Leu Tyr Ser Leu Gln Ala
            340                 345                 350         
Ala Leu Thr Ile Gln Asp Ser His Ile Glu Ile His Arg Leu Val Leu
        355                 360                 365             
Gln Gln Gln Glu Gly Leu Ser Leu Gly His Ser Ile Leu Arg Gly Gly
    370                 375                 380                 
Pro Leu Gln Asp Gln Lys Ser Arg Asp Ala Asp Arg Gln His Glu Glu
385                 390                 395                 400 
Leu Ala Asn Val His Gln Leu Gln His Gln Leu Gln Gln Glu Gln Arg
                405                 410                 415     
Arg Trp Leu Arg Arg Cys Glu Gln Gln Gln Arg Ala Gln Ala Thr Arg
            420                 425                 430         
Glu Ser Trp Leu Gln Glu Arg Glu Arg Glu Cys Gln Ser Gln Glu Glu
        435                 440                 445             
Leu Leu Leu Arg Ser Arg Gly Glu Leu Asp Leu Gln Leu Gln Glu Tyr
    450                 455                 460                 
Gln His Ser Leu Glu Arg Leu Arg Glu Gly Gln Arg Leu Val Glu Arg
465                 470                 475                 480 
Glu Gln Ala Arg Met Arg Ala Gln Gln Ser Leu Leu Gly His Trp Lys
                485                 490                 495     
His Gly Arg Gln Arg Ser Leu Pro Ala Val Leu Leu Pro Gly Gly Pro
            500                 505                 510         
Glu Val Met Glu Leu Asn Arg Ser Glu Ser Leu Cys His Glu Asn Ser
        515                 520                 525             
Phe Phe Ile Asn Glu Ala Leu Val Gln Met Ser Phe Asn Thr Phe Asn
    530                 535                 540                 
Lys Leu Asn Pro Ser Val Ile His Gln Asp Ala Thr Tyr Pro Thr Thr
545                 550                 555                 560 
Gln Ser His Ser Asp Leu Val Arg Thr Ser Glu His Gln Val Asp Leu
                565                 570                 575     
Lys Val Asp Pro Ser Gln Pro Ser Asn Val Ser His Lys Leu Trp Thr
            580                 585                 590         
Ala Ala Gly Ser Gly His Gln Ile Leu Pro Phe Gln Glu Ser Ser Lys
        595                 600                 605             
Asp Ser Cys Lys Asn Asp Leu Asp Thr Ser His Thr Glu Ser Pro Thr
    610                 615                 620                 
Pro His Asp Ser Asn Ser His Arg Pro Gln Leu Gln Ala Phe Ile Thr
625                 630                 635                 640 
Glu Ala Lys Leu Asn Leu Pro Thr Arg Thr Met Thr Arg Gln Asp Gly
                645                 650                 655     
Glu Thr Gly Asp Gly Ala Lys Glu Asn Ile Val Tyr Leu
            660                 665                 


<210> 1073
<211> 328
<212> PRT
<213> Homo sapiens

<400> 1073
Met Ala Ala Val Val Val Ala Ala Ala Gly Gly Ala Gly Pro Ala Val
 1               5                  10                  15      
Leu Gln Val Ala Gly Leu Tyr Arg Gly Leu Cys Ala Val Arg Ser Arg
            20                  25                  30          
Ala Leu Gly Leu Gly Leu Val Ser Pro Ala Gln Leu Arg Val Phe Pro
        35                  40                  45              
Val Arg Pro Gly Ser Gly Arg Pro Glu Gly Gly Ala Asp Gly Ser Gly
    50                  55                  60                  
Val Gly Ala Glu Ala Glu Leu Gln Ala Asn Pro Phe Tyr Asp Arg Tyr
65                  70                  75                  80  
Arg Asp Lys Ile Gln Leu Leu Arg Arg Ser Asp Pro Ala Ala Phe Glu
                85                  90                  95      
Ser Arg Leu Glu Lys Arg Ser Glu Phe Arg Lys Gln Pro Val Gly His
            100                 105                 110         
Ser Arg Gln Gly Asp Phe Ile Lys Cys Val Glu Gln Lys Thr Asp Ala
        115                 120                 125             
Leu Gly Lys Gln Ser Val Asn Arg Gly Phe Thr Lys Asp Lys Thr Leu
    130                 135                 140                 
Ser Ser Ile Phe Asn Ile Glu Met Val Lys Glu Lys Thr Ala Glu Glu
145                 150                 155                 160 
Ile Lys Gln Ile Trp Gln Gln Tyr Phe Ala Ala Lys Asp Thr Val Tyr
                165                 170                 175     
Ala Val Ile Pro Ala Glu Lys Phe Asp Leu Ile Trp Asn Arg Ala Gln
            180                 185                 190         
Ser Cys Pro Thr Phe Leu Cys Ala Leu Pro Arg Arg Glu Gly Tyr Glu
        195                 200                 205             
Phe Phe Val Gly Gln Trp Thr Gly Thr Glu Leu His Phe Thr Ala Leu
    210                 215                 220                 
Ile Asn Ile Gln Thr Arg Gly Glu Ala Ala Ala Ser Gln Leu Ile Leu
225                 230                 235                 240 
Tyr His Tyr Pro Glu Leu Lys Glu Glu Lys Gly Ile Val Leu Met Thr
                245                 250                 255     
Ala Glu Met Asp Ser Thr Phe Leu Asn Val Ala Glu Ala Gln Cys Ile
            260                 265                 270         
Ala Asn Gln Val Gln Leu Phe Tyr Ala Thr Asp Arg Lys Glu Thr Tyr
        275                 280                 285             
Gly Leu Val Glu Thr Phe Asn Leu Arg Pro Asn Glu Phe Lys Tyr Met
    290                 295                 300                 
Ser Val Ile Ala Glu Leu Glu Gln Ser Gly Leu Gly Ala Glu Leu Lys
305                 310                 315                 320 
Cys Ala Gln Asn Gln Asn Lys Thr
                325             


<210> 1074
<211> 384
<212> PRT
<213> Homo sapiens

<400> 1074
Met Asn Tyr Pro Ser Ser Leu Ala Leu Leu Arg Glu Leu Ser Leu Ser
 1               5                  10                  15      
Pro Pro Ala Ala Leu Trp Leu Gln Glu Arg Gln Ala Gln Leu Arg His
            20                  25                  30          
Ser Leu Pro Leu Gln Ser Phe Leu Leu Lys Pro Val Gln Arg Ile Leu
        35                  40                  45              
Lys Tyr His Leu Leu Leu Gln Glu Leu Gly Lys His Trp Ala Glu Gly
    50                  55                  60                  
Pro Gly Thr Gly Gly Arg Glu Met Val Glu Glu Ala Ile Val Ser Met
65                  70                  75                  80  
Thr Ala Val Ala Trp Tyr Ile Asn Asp Met Lys Arg Lys Gln Glu His
                85                  90                  95      
Ala Ala Arg Leu Gln Glu Val Gln Arg Arg Leu Gly Gly Trp Thr Gly
            100                 105                 110         
Pro Glu Leu Ser Ala Phe Gly Glu Leu Val Leu Glu Gly Ala Phe Arg
        115                 120                 125             
Gly Gly Gly Gly Gly Gly Pro Arg Leu Arg Gly Gly Glu Arg Leu Leu
    130                 135                 140                 
Phe Leu Phe Ser Arg Met Leu Leu Val Ala Lys Arg Arg Gly Leu Glu
145                 150                 155                 160 
Tyr Thr Tyr Lys Gly His Ile Phe Cys Cys Asn Leu Ser Val Ser Glu
                165                 170                 175     
Ser Pro Arg Asp Pro Leu Gly Phe Lys Val Ser Asp Leu Thr Ile Pro
            180                 185                 190         
Lys His Arg His Leu Leu Gln Ala Lys Asn Gln Glu Glu Lys Arg Leu
        195                 200                 205             
Trp Ile His Cys Leu Gln Arg Leu Phe Phe Glu Asn His Pro Ala Ser
    210                 215                 220                 
Ile Pro Ala Lys Ala Lys Gln Val Leu Leu Glu Asn Ser Leu His Cys
225                 230                 235                 240 
Ala Pro Lys Ser Lys Pro Val Leu Glu Pro Leu Thr Pro Pro Leu Gly
                245                 250                 255     
Ser Pro Arg Pro Arg Asp Ala Arg Ser Phe Thr Pro Gly Arg Arg Asn
            260                 265                 270         
Thr Ala Pro Ser Pro Gly Pro Ser Val Ile Arg Arg Gly Arg Arg Gln
        275                 280                 285             
Ser Glu Pro Val Lys Asp Pro Tyr Val Met Phe Pro Gln Asn Ala Lys
    290                 295                 300                 
Pro Gly Phe Lys His Ala Gly Ser Glu Gly Glu Leu Tyr Pro Pro Glu
305                 310                 315                 320 
Ser Gln Pro Pro Val Ser Gly Ser Ala Pro Pro Glu Asp Leu Glu Asp
                325                 330                 335     
Ala Gly Pro Pro Thr Leu Asp Pro Ser Gly Thr Ser Ile Thr Glu Glu
            340                 345                 350         
Ile Leu Glu Leu Leu Asn Gln Arg Gly Leu Arg Asp Pro Gly Glu Ser
        355                 360                 365             
Met Gly Leu His Arg Ala Gln Gly Ala Pro Asp Ala Pro Phe His Met
    370                 375                 380                 


<210> 1075
<211> 194
<212> PRT
<213> Homo sapiens

<400> 1075
Met Gln Ala Val Arg Asn Ala Gly Ser Arg Phe Leu Arg Ser Trp Thr
 1               5                  10                  15      
Trp Pro Gln Thr Ala Gly Arg Val Val Ala Arg Thr Pro Ala Gly Thr
            20                  25                  30          
Ile Cys Thr Gly Ala Arg Gln Leu Gln Asp Ala Ala Ala Lys Gln Lys
        35                  40                  45              
Val Glu Gln Tyr Ala Ala Pro Ser His Thr Lys Phe Ser Ile Tyr Pro
    50                  55                  60                  
Pro Ile Pro Gly Glu Glu Ser Ser Leu Arg Trp Ala Gly Lys Lys Phe
65                  70                  75                  80  
Glu Glu Ile Pro Ile Ala His Ile Lys Ala Ser His Asn Asn Thr Gln
                85                  90                  95      
Ile Gln Val Val Ser Ala Ser Asn Glu Pro Leu Ala Phe Ala Ser Cys
            100                 105                 110         
Gly Thr Glu Gly Phe Arg Asn Ala Lys Lys Gly Thr Gly Ile Ala Ala
        115                 120                 125             
Gln Thr Ala Gly Ile Ala Ala Ala Ala Arg Ala Lys Gln Lys Gly Val
    130                 135                 140                 
Ile His Ile Arg Val Val Val Lys Gly Leu Gly Pro Gly Arg Leu Ser
145                 150                 155                 160 
Ala Met His Gly Leu Ile Met Gly Gly Leu Glu Val Ile Ser Ile Thr
                165                 170                 175     
Asp Asn Thr Pro Ile Pro His Asn Gly Cys Arg Pro Arg Lys Ala Arg
            180                 185                 190         
Lys Leu
        


<210> 1076
<211> 181
<212> PRT
<213> Homo sapiens

<400> 1076
Met Ser Ser Ala Ile Arg Ser Gln His Ser Gly Val Asp Ile Cys Ile
 1               5                  10                  15      
Asn Asn Ala Gly Leu Ala Arg Pro Asp Thr Leu Leu Ser Gly Ser Thr
            20                  25                  30          
Ser Gly Trp Lys Asp Met Phe Asn Val Asn Val Leu Ala Leu Ser Ile
        35                  40                  45              
Cys Thr Arg Glu Ala Tyr Gln Ser Met Lys Glu Arg Asn Val Asp Asp
    50                  55                  60                  
Gly His Ile Ile Asn Ile Asn Ser Met Ser Gly His Arg Val Leu Pro
65                  70                  75                  80  
Leu Ser Val Thr His Phe Tyr Ser Ala Thr Lys Tyr Ala Val Thr Ala
                85                  90                  95      
Leu Thr Glu Gly Leu Arg Gln Glu Leu Arg Glu Ala Gln Thr His Ile
            100                 105                 110         
Arg Ala Thr Cys Ile Ser Pro Gly Val Val Glu Thr Gln Phe Ala Phe
        115                 120                 125             
Lys Leu His Asp Lys Asp Pro Glu Lys Ala Ala Ala Thr Tyr Glu Gln
    130                 135                 140                 
Met Lys Cys Leu Lys Pro Glu Asp Val Ala Glu Ala Val Ile Tyr Val
145                 150                 155                 160 
Leu Ser Thr Pro Ala His Ile Gln Ile Gly Asp Ile Gln Met Arg Pro
                165                 170                 175     
Thr Glu Gln Val Thr
            180     


<210> 1077
<211> 310
<212> PRT
<213> Homo sapiens

<400> 1077
Met Ile Ala Glu Asp Lys Ser Ile Gly Ser Pro Met Glu Glu Arg Glu
 1               5                  10                  15      
Lys Leu Leu Lys Gln Ile Lys Asp Asp Asn Gln Glu Ile Ala Ser Met
            20                  25                  30          
Glu Arg Gln Leu Thr Asp Thr Lys Glu Lys Ile Asn Gln Phe Ile Glu
        35                  40                  45              
Glu Ile Arg Gln Leu Asp Met Asp Leu Glu Glu His Gln Gly Glu Met
    50                  55                  60                  
Asn Gln Lys Tyr Lys Glu Leu Lys Lys Arg Glu Glu His Met Asp Thr
65                  70                  75                  80  
Phe Ile Glu Thr Phe Glu Glu Thr Lys Asn Gln Glu Leu Lys Arg Lys
                85                  90                  95      
Ala Gln Ile Glu Ala Asn Ile Val Ala Leu Leu Glu His Cys Ser Arg
            100                 105                 110         
Asn Ile Asn Arg Ile Glu Gln Ile Ser Ser Ile Thr Asn Gln Glu Leu
        115                 120                 125             
Lys Met Met Gln Asp Asp Leu Asn Phe Lys Ser Thr Glu Val Gln Lys
    130                 135                 140                 
Ser Gln Ser Thr Ala Gln Asn Leu Thr Ser Asp Ile Gln Arg Leu Gln
145                 150                 155                 160 
Leu Asp Leu Gln Lys Met Glu Leu Leu Glu Ser Lys Met Thr Glu Glu
                165                 170                 175     
Gln His Ser Leu Lys Ser Lys Ile Lys Gln Met Thr Thr Asp Leu Glu
            180                 185                 190         
Ile Tyr Asn Asp Leu Pro Ala Leu Lys Ser Ser Gly Glu Glu Lys Ile
        195                 200                 205             
Lys Lys Leu His Gln Glu Arg Met Ile Leu Ser Thr His Arg Asn Ala
    210                 215                 220                 
Phe Lys Lys Ile Met Glu Lys Gln Asn Ile Glu Tyr Glu Ala Leu Lys
225                 230                 235                 240 
Thr Gln Leu Gln Glu Asn Glu Thr His Ser Gln Leu Thr Asn Leu Glu
                245                 250                 255     
Arg Lys Trp Gln His Leu Glu Gln Asn Asn Phe Ala Met Lys Glu Phe
            260                 265                 270         
Ile Ala Thr Lys Ser Gln Glu Ser Asp Tyr Gln Pro Ile Lys Lys Asn
        275                 280                 285             
Val Thr Lys Gln Ile Ala Glu Tyr Asn Lys Thr Ile Val Asp Ala Leu
    290                 295                 300                 
His Ser Ile Ser Gly Asn
305                 310 


<210> 1078
<211> 509
<212> PRT
<213> Homo sapiens

<400> 1078
Met Ala His Phe Glu Glu Met Gly Met Cys Val Glu Thr Asp Met Glu
 1               5                  10                  15      
Leu Leu Val Cys Thr Phe Cys Ile Lys Phe Ser Arg His Val Lys Lys
            20                  25                  30          
Leu Gln Leu Ile Glu Gly Arg Gln His Arg Ser Thr Trp Ser Pro Thr
        35                  40                  45              
Met Val Val Leu Phe Arg Trp Val Pro Val Thr Asp Ala Tyr Trp Gln
    50                  55                  60                  
Ile Leu Phe Ser Val Leu Lys Val Thr Arg Asn Leu Lys Glu Leu Asp
65                  70                  75                  80  
Leu Ser Gly Asn Ser Leu Ser His Ser Ala Val Lys Ser Leu Cys Lys
                85                  90                  95      
Thr Leu Arg Arg Pro Arg Cys Leu Leu Glu Thr Leu Arg Leu Ala Gly
            100                 105                 110         
Cys Gly Leu Thr Ala Glu Asp Cys Lys Asp Leu Ala Phe Gly Leu Arg
        115                 120                 125             
Ala Asn Gln Thr Leu Thr Glu Leu Asp Leu Ser Phe Asn Val Leu Thr
    130                 135                 140                 
Asp Ala Gly Ala Lys His Leu Cys Gln Arg Leu Arg Gln Pro Ser Cys
145                 150                 155                 160 
Lys Leu Gln Arg Leu Gln Leu Val Ser Cys Gly Leu Thr Ser Asp Cys
                165                 170                 175     
Cys Gln Asp Leu Ala Ser Val Leu Ser Ala Ser Pro Ser Leu Lys Glu
            180                 185                 190         
Leu Asp Leu Gln Gln Asn Asn Leu Asp Asp Val Gly Val Arg Leu Leu
        195                 200                 205             
Cys Glu Gly Leu Arg His Pro Ala Cys Lys Leu Ile Arg Leu Gly Leu
    210                 215                 220                 
Asp Gln Thr Thr Leu Ser Asp Glu Met Arg Gln Glu Leu Arg Ala Leu
225                 230                 235                 240 
Glu Gln Glu Lys Pro Gln Leu Leu Ile Phe Ser Arg Arg Lys Pro Ser
                245                 250                 255     
Val Met Thr Pro Thr Glu Gly Leu Asp Thr Gly Glu Met Ser Asn Ser
            260                 265                 270         
Thr Ser Ser Leu Lys Arg Gln Arg Leu Gly Ser Glu Arg Ala Ala Ser
        275                 280                 285             
His Val Ala Gln Ala Asn Leu Lys Leu Leu Asp Val Ser Lys Ile Phe
    290                 295                 300                 
Pro Ile Ala Glu Ile Ala Glu Glu Ser Ser Pro Glu Val Val Pro Val
305                 310                 315                 320 
Glu Leu Leu Cys Val Pro Ser Pro Ala Ser Gln Gly Asp Leu His Thr
                325                 330                 335     
Lys Pro Leu Gly Thr Asp Asp Asp Phe Trp Gly Pro Thr Gly Pro Val
            340                 345                 350         
Ala Thr Glu Val Val Asp Lys Glu Lys Asn Leu Tyr Arg Val His Phe
        355                 360                 365             
Pro Val Ala Gly Ser Tyr Arg Trp Pro Asn Thr Gly Leu Cys Phe Val
    370                 375                 380                 
Met Arg Glu Ala Val Thr Val Glu Ile Glu Phe Cys Val Trp Asp Gln
385                 390                 395                 400 
Phe Leu Gly Glu Ile Asn Pro Gln His Ser Trp Met Val Ala Gly Pro
                405                 410                 415     
Leu Leu Asp Ile Lys Ala Glu Pro Gly Ala Val Glu Ala Val His Leu
            420                 425                 430         
Pro His Phe Val Ala Leu Gln Gly Gly His Val Asp Thr Ser Leu Phe
        435                 440                 445             
Gln Met Ala His Phe Lys Glu Glu Gly Met Leu Leu Glu Lys Pro Ala
    450                 455                 460                 
Arg Val Glu Leu His His Ile Val Leu Glu Asn Pro Ser Phe Ser Pro
465                 470                 475                 480 
Leu Gly Val Leu Leu Lys Met Ile His Asn Ala Leu Arg Phe Ile Pro
                485                 490                 495     
Val Thr Ser Val Val Leu Leu Tyr His Arg Arg Pro Ser
            500                 505                 


<210> 1079
<211> 121
<212> PRT
<213> Homo sapiens

<400> 1079
Met Glu Lys Asp Arg Glu Ile Cys Arg Leu Arg Ser Gln Leu Asn Gln
 1               5                  10                  15      
Tyr His Lys Asp Val Ser Lys Arg Glu Gly Ser Cys Ser Asp Phe Gln
            20                  25                  30          
Phe Lys Phe His Glu Leu Thr Ser Leu Leu Glu Glu Lys Asp Ser Leu
        35                  40                  45              
Ile Lys Arg Gln Ser Glu Glu Leu Ser Lys Leu Arg Gln Glu Ile Tyr
    50                  55                  60                  
Ser Ser His Asn Gln Pro Ser Thr Gly Gly Arg Thr Thr Ile Thr Thr
65                  70                  75                  80  
Lys Lys Tyr Arg Thr Gln Tyr Pro Ile Leu Gly Leu Leu Tyr Asp Asp
                85                  90                  95      
Tyr Glu Tyr Ile Pro Pro Gly Ser Glu Thr Gln Thr Ile Val Ile Glu
            100                 105                 110         
Lys Thr Glu Asp Lys Tyr Thr Cys Pro
        115                 120     


<210> 1080
<211> 412
<212> PRT
<213> Homo sapiens

<400> 1080
Met Val Leu Phe Ser Asp Ser Ser Leu Pro His Trp Gln Gln Gln Pro
 1               5                  10                  15      
Pro Gln Pro Ala Pro Pro Pro Pro Leu Phe Pro Arg Gln Gln Gln Val
            20                  25                  30          
Gln Val Asn Lys Gly Arg Val Asn Cys His Pro Arg Cys Arg Tyr Ile
        35                  40                  45              
Lys Thr Lys Pro Cys His Gln Leu Ser His Gln Val Trp Val Gln Gln
    50                  55                  60                  
Lys Pro Ser His Arg Leu Leu Ser Leu Gln Leu Ser Pro Ser Pro Lys
65                  70                  75                  80  
Pro Ser Pro Ser Pro Gln Leu Ser Leu Lys Phe Arg Leu Ser Leu Lys
                85                  90                  95      
Phe Arg Pro Lys Gln Leu Phe His Pro Met Ser Leu Leu Lys His Asn
            100                 105                 110         
Pro Pro Thr His Ser His Pro Ser Pro Lys Leu Gln Ser Gln Ser Gln
        115                 120                 125             
Pro Gln Ser Asn Val Gln Gly Gln Ser Pro Val Arg Val Gln Ser Pro
    130                 135                 140                 
Ser Gln Thr Arg Ile Arg Pro Ser Thr Pro Ser Gln Leu Ser Pro Gly
145                 150                 155                 160 
Gln Gln Ser Gln Val Gln Thr Thr Thr Ser Gln Pro Ile Pro Ile Gln
                165                 170                 175     
Pro His Thr Ser Leu Gln Ile Pro Ser Gln Gly Gln Pro Gln Ser Gln
            180                 185                 190         
Pro Gln Val Val Met Lys His Asn Ala Val Ile Glu His Leu Lys Gln
        195                 200                 205             
Lys Lys Ser Met Thr Pro Ala Glu Arg Glu Glu Asn Gln Arg Met Ile
    210                 215                 220                 
Val Cys Asn Gln Val Met Lys Tyr Ile Leu Asp Lys Ile Asp Lys Glu
225                 230                 235                 240 
Glu Lys Gln Ala Ala Lys Lys Arg Lys Arg Glu Glu Ser Val Glu Gln
                245                 250                 255     
Lys Arg Ser Lys Gln Asn Ala Thr Lys Leu Ser Ala Leu Leu Phe Lys
            260                 265                 270         
His Lys Glu Gln Leu Arg Ala Glu Ile Leu Lys Lys Arg Ala Leu Leu
        275                 280                 285             
Asp Lys Asp Leu Gln Ile Glu Val Gln Glu Glu Leu Lys Arg Asp Leu
    290                 295                 300                 
Lys Ile Lys Lys Glu Lys Asp Leu Met Gln Leu Ala Gln Ala Thr Ala
305                 310                 315                 320 
Val Ala Ala Pro Cys Pro Pro Val Thr Pro Ala Pro Pro Ala Pro Pro
                325                 330                 335     
Ala Pro Pro Ala Pro Pro Pro Ser Pro Pro Pro Pro Pro Ala Val Gln
            340                 345                 350         
His Thr Gly Leu Leu Ser Thr Pro Thr Leu Pro Ala Ala Ser Gln Lys
        355                 360                 365             
Arg Lys Arg Glu Glu Glu Lys Asp Ser Ser Ser Lys Ser Lys Lys Lys
    370                 375                 380                 
Lys Met Ile Ser Thr Thr Ser Lys Glu Thr Lys Lys Asp Thr Lys Leu
385                 390                 395                 400 
Tyr Cys Ile Cys Lys Thr Pro Tyr Asp Glu Ser Lys
                405                 410         


<210> 1081
<211> 217
<212> PRT
<213> Homo sapiens

<400> 1081
Leu Gly Gly Arg Ser Pro Pro Cys Pro Arg Leu Gly Ala Pro Pro Pro
 1               5                  10                  15      
Leu Pro Cys Arg Ala Arg Pro Gly Gly Val Val Gly Gly Gly Pro Gly
            20                  25                  30          
Gly Gly Pro Ala Trp Ala Ala Pro Ala Met Asn Gly Leu Ser Leu Ser
        35                  40                  45              
Glu Leu Cys Cys Leu Phe Cys Cys Pro Pro Cys Pro Gly Arg Ile Ala
    50                  55                  60                  
Ala Lys Leu Ala Phe Leu Pro Pro Glu Ala Thr Tyr Ser Leu Val Pro
65                  70                  75                  80  
Glu Pro Glu Pro Gly Pro Gly Gly Ala Gly Ala Ala Pro Leu Gly Thr
                85                  90                  95      
Leu Arg Ala Ser Ser Gly Ala Pro Gly Arg Trp Lys Leu His Leu Thr
            100                 105                 110         
Glu Arg Ala Asp Phe Gln Tyr Ser Gln Arg Glu Leu Asp Thr Ile Glu
        115                 120                 125             
Val Phe Pro Thr Lys Ser Ala Arg Gly Asn Arg Val Ser Cys Met Tyr
    130                 135                 140                 
Val Arg Cys Val Pro Gly Ala Arg Tyr Thr Val Leu Phe Ser His Gly
145                 150                 155                 160 
Asn Ala Val Asp Leu Gly Gln Met Ser Ser Phe Tyr Ile Gly Leu Gly
                165                 170                 175     
Ser Arg Leu His Cys Asn Ile Phe Ser Tyr Asp Tyr Ser Gly Tyr Gly
            180                 185                 190         
Ala Ser Ser Gly Arg Pro Ser Glu Arg Asn Leu Tyr Ala Asp Ile Asp
        195                 200                 205             
Ala Ala Trp Gln Ala Leu Arg Thr Arg
    210                 215         


<210> 1082
<211> 75
<212> PRT
<213> Homo sapiens

<400> 1082
Thr Met Ser Ala Leu Leu Leu Thr Val Asn Phe Gly Leu Ser Val Gly
 1               5                  10                  15      
Arg Tyr Trp Glu Thr Val Glu Arg Leu Lys Ile Asn Gln Phe Tyr Gly
            20                  25                  30          
Ala Pro Thr Ala Val Arg Leu Leu Leu Lys Tyr Gly Asp Ala Trp Val
        35                  40                  45              
Lys Lys Tyr Asp Arg Ser Ser Leu Arg Thr Leu Gly Ser Gly Glu Arg
    50                  55                  60                  
Pro Ala Leu Gln Gln Glu Arg Leu Cys Leu Pro
65                  70                  75  


<210> 1083
<211> 1430
<212> PRT
<213> Homo sapiens

<400> 1083
Glu Pro Glu Val His Ala Pro Glu Ser Gly Leu Arg Thr Ser Leu Gly
 1               5                  10                  15      
Thr Ala Ser Gly Ser Arg Arg Ser Arg Ala Ala Ser Ser Arg Gly Trp
            20                  25                  30          
Arg Leu Pro Gly Arg Thr Leu Leu Gly Arg Ser Ala Met Pro Glu Gly
        35                  40                  45              
Ala Gln Gly Leu Ser Leu Ser Lys Pro Ser Pro Ser Leu Gly Cys Gly
    50                  55                  60                  
Arg Arg Gly Glu Val Cys Asp Cys Gly Thr Val Cys Glu Thr Arg Thr
65                  70                  75                  80  
Ala Pro Ala Ala Pro Thr Met Ala Ser Pro Arg Gly Ser Gly Ser Ser
                85                  90                  95      
Thr Ser Leu Ser Thr Val Gly Ser Glu Gly Asp Pro Ala Pro Gly Pro
            100                 105                 110         
Thr Pro Ala Cys Ser Ala Ser Arg Pro Glu Pro Leu Pro Gly Pro Pro
        115                 120                 125             
Ile Arg Leu His Leu Ser Pro Val Gly Ile Pro Gly Ser Ala Arg Pro
    130                 135                 140                 
Ser Arg Leu Glu Arg Val Ala Arg Glu Ile Val Glu Thr Glu Arg Ala
145                 150                 155                 160 
Tyr Val Arg Asp Leu Arg Ser Ile Val Glu Asp Tyr Leu Gly Pro Leu
                165                 170                 175     
Leu Asp Gly Gly Val Leu Gly Leu Ser Val Glu Gln Val Gly Thr Leu
            180                 185                 190         
Phe Ala Asn Ile Glu Asp Ile Tyr Glu Phe Ser Ser Glu Leu Leu Glu
        195                 200                 205             
Asp Leu Glu Asn Ser Ser Ser Ala Gly Gly Ile Ala Glu Cys Phe Val
    210                 215                 220                 
Gln Arg Ser Glu Asp Phe Asp Ile Tyr Thr Leu Tyr Cys Met Asn Tyr
225                 230                 235                 240 
Pro Ser Ser Leu Ala Leu Leu Arg Glu Leu Ser Leu Ser Pro Pro Ala
                245                 250                 255     
Ala Leu Trp Leu Gln Glu Arg Gln Ala Gln Leu Arg His Ser Leu Pro
            260                 265                 270         
Leu Gln Ser Phe Leu Leu Lys Pro Val Gln Arg Ile Leu Lys Tyr His
        275                 280                 285             
Leu Leu Leu Gln Glu Leu Gly Lys His Trp Ala Glu Gly Pro Gly Thr
    290                 295                 300                 
Gly Gly Arg Glu Met Val Glu Glu Ala Ile Val Ser Met Thr Ala Val
305                 310                 315                 320 
Ala Trp Tyr Ile Asn Asp Met Lys Arg Lys Gln Glu His Ala Ala Arg
                325                 330                 335     
Leu Gln Glu Val Gln Arg Arg Leu Gly Gly Trp Thr Gly Pro Glu Leu
            340                 345                 350         
Ser Ala Phe Gly Glu Leu Val Leu Glu Gly Ala Phe Arg Gly Gly Gly
        355                 360                 365             
Gly Gly Gly Pro Arg Leu Arg Gly Gly Glu Arg Leu Leu Phe Leu Phe
    370                 375                 380                 
Ser Arg Met Leu Leu Val Ala Lys Arg Arg Gly Leu Glu Tyr Thr Tyr
385                 390                 395                 400 
Lys Gly His Ile Phe Cys Cys Asn Leu Ser Val Ser Glu Ser Pro Arg
                405                 410                 415     
Asp Pro Leu Gly Phe Lys Val Ser Asp Leu Thr Ile Pro Lys His Arg
            420                 425                 430         
His Leu Leu Gln Ala Lys Asn Gln Glu Glu Lys Arg Leu Trp Ile His
        435                 440                 445             
Cys Leu Gln Arg Leu Phe Phe Glu Asn His Pro Ala Ser Ile Pro Ala
    450                 455                 460                 
Lys Ala Lys Gln Val Leu Leu Glu Asn Ser Leu His Cys Ala Pro Lys
465                 470                 475                 480 
Ser Lys Pro Val Leu Glu Pro Leu Thr Pro Pro Leu Gly Ser Pro Arg
                485                 490                 495     
Pro Arg Asp Ala Arg Ser Phe Thr Pro Gly Arg Arg Asn Thr Ala Pro
            500                 505                 510         
Ser Pro Gly Pro Ser Val Ile Arg Arg Gly Arg Arg Gln Ser Glu Pro
        515                 520                 525             
Val Lys Asp Pro Tyr Val Met Phe Pro Gln Asn Ala Lys Pro Gly Phe
    530                 535                 540                 
Lys His Ala Gly Ser Glu Gly Glu Leu Tyr Pro Pro Glu Ser Gln Pro
545                 550                 555                 560 
Pro Val Ser Gly Ser Ala Pro Pro Glu Asp Leu Glu Asp Ala Gly Pro
                565                 570                 575     
Pro Thr Leu Asp Pro Ser Gly Thr Ser Ile Thr Glu Glu Ile Leu Glu
            580                 585                 590         
Leu Leu Asn Gln Arg Gly Leu Arg Asp Pro Gly Pro Ser Thr His Asp
        595                 600                 605             
Ile Pro Lys Phe Pro Gly Asp Ser Gln Val Pro Gly Asp Ser Glu Thr
    610                 615                 620                 
Leu Thr Phe Gln Ala Leu Pro Ser Arg Asp Ser Ser Glu Glu Glu Glu
625                 630                 635                 640 
Glu Glu Glu Glu Gly Leu Glu Met Asp Glu Arg Gly Pro Ser Pro Leu
                645                 650                 655     
His Val Leu Glu Gly Leu Glu Ser Ser Ile Ala Ala Glu Met Pro Ser
            660                 665                 670         
Ile Pro Cys Leu Thr Lys Ile Pro Asp Val Pro Asn Leu Pro Glu Ile
        675                 680                 685             
Pro Ser Arg Cys Glu Ile Pro Glu Gly Ser Arg Leu Pro Ser Leu Ser
    690                 695                 700                 
Asp Ile Ser Asp Val Phe Glu Met Pro Cys Leu Pro Ala Ile Pro Ser
705                 710                 715                 720 
Val Pro Asn Thr Pro Ser Leu Ser Ser Thr Pro Thr Leu Ser Cys Asp
                725                 730                 735     
Ser Trp Leu Gln Gly Pro Leu Gln Glu Pro Ala Glu Ala Pro Ala Thr
            740                 745                 750         
Arg Arg Glu Leu Phe Ser Gly Ser Asn Pro Gly Lys Leu Gly Glu Pro
        755                 760                 765             
Pro Ser Gly Gly Lys Ala Gly Pro Glu Glu Asp Glu Glu Gly Val Ser
    770                 775                 780                 
Phe Thr Asp Phe Gln Pro Gln Asp Val Thr Gln His Gln Gly Phe Pro
785                 790                 795                 800 
Asp Glu Leu Ala Phe Arg Ser Cys Ser Glu Ile Arg Ser Ala Trp Gln
                805                 810                 815     
Ala Leu Glu Gln Gly Gln Leu Ala Arg Pro Gly Phe Pro Glu Pro Leu
            820                 825                 830         
Leu Ile Leu Glu Asp Ser Asp Leu Gly Gly Asp Ser Gly Ser Gly Lys
        835                 840                 845             
Ala Gly Ala Pro Ser Ser Glu Arg Thr Ala Ser Arg Val Arg Glu Leu
    850                 855                 860                 
Ala Arg Leu Tyr Ser Glu Arg Ile Gln Gln Met Gln Arg Ala Glu Thr
865                 870                 875                 880 
Arg Ala Ser Ala Asn Ala Pro Arg Arg Arg Pro Arg Val Leu Ala Gln
                885                 890                 895     
Pro Gln Pro Ser Pro Cys Leu Pro Gln Glu Gln Ala Glu Pro Gly Leu
            900                 905                 910         
Leu Pro Ala Phe Gly His Val Leu Val Cys Glu Leu Ala Phe Pro Leu
        915                 920                 925             
Thr Cys Ala Gln Glu Ser Val Pro Leu Gly Pro Ala Val Trp Val Gln
    930                 935                 940                 
Ala Ala Ile Pro Leu Ser Lys Gln Gly Gly Ser Pro Asp Gly Gln Gly
945                 950                 955                 960 
Leu His Val Ser Asn Leu Pro Lys Gln Asp Leu Pro Gly Ile His Val
                965                 970                 975     
Ser Ala Ala Thr Leu Leu Pro Glu Gln Gly Gly Ser Arg His Val Gln
            980                 985                 990         
Ala Pro Ala Ala Thr Pro Leu Pro Lys Gln Glu Gly Pro Leu His Leu
        995                 1000                1005            
Gln Val Pro Ala Leu Thr Thr Phe Ser Asp Gln Gly His Pro Glu Ile
    1010                1015                1020                
Gln Val Pro Ala Thr Thr Pro Leu Pro Glu His Lys Ser His Met Val
1025                1030                1035                1040
Ile Pro Ala Pro Ser Thr Ala Phe Cys Pro Glu Gln Gly His Cys Ala
                1045                1050                1055    
Asp Ile His Val Pro Thr Thr Pro Ala Leu Pro Lys Glu Ile Cys Ser
            1060                1065                1070        
Asp Phe Thr Val Ser Val Thr Thr Pro Val Pro Lys Gln Glu Gly His
        1075                1080                1085            
Leu Asp Ser Glu Ser Pro Thr Asn Ile Pro Leu Thr Lys Gln Gly Gly
    1090                1095                1100                
Ser Arg Asp Val Gln Gly Pro Asp Pro Val Cys Ser Gln Pro Ile Gln
1105                1110                1115                1120
Pro Leu Ser Trp His Gly Ser Ser Leu Asp Pro Gln Gly Pro Gly Asp
                1125                1130                1135    
Thr Leu Pro Pro Leu Pro Cys His Leu Pro Asp Leu Gln Ile Pro Gly
            1140                1145                1150        
Thr Ser Pro Leu Pro Ala His Gly Ser His Leu Asp His Arg Ile Pro
        1155                1160                1165            
Ala Asn Ala Pro Leu Ser Leu Ser Gln Glu Leu Pro Asp Thr Gln Val
    1170                1175                1180                
Pro Ala Thr Thr Pro Leu Pro Leu Pro Gln Val Leu Thr Asp Ile Trp
1185                1190                1195                1200
Val Gln Ala Leu Pro Thr Ser Pro Lys Gln Gly Ser Leu Pro Asp Ile
                1205                1210                1215    
Gln Gly Pro Ala Ala Ala Pro Pro Leu Pro Glu Pro Ser Leu Thr Asp
            1220                1225                1230        
Thr Gln Val Gln Lys Leu Thr Pro Ser Leu Glu Gln Lys Ser Leu Ile
        1235                1240                1245            
Asp Ala His Val Pro Ala Ala Thr Pro Leu Pro Glu Arg Gly Gly Ser
    1250                1255                1260                
Leu Asp Ile Gln Gly Leu Ser Pro Thr Pro Val Gln Thr Thr Met Val
1265                1270                1275                1280
Leu Ser Lys Pro Gly Gly Ser Leu Ala Ser His Val Ala Arg Leu Glu
                1285                1290                1295    
Ser Ser Asp Leu Thr Pro Pro His Ser Pro Pro Pro Ser Ser Arg Gln
            1300                1305                1310        
Leu Leu Gly Pro Asn Ala Ala Ala Leu Ser Arg Tyr Leu Ala Ala Ser
        1315                1320                1325            
Tyr Ile Ser Gln Ser Leu Ala Arg Arg Gln Gly Pro Gly Gly Gly Ala
    1330                1335                1340                
Pro Ala Ala Ser Arg Gly Ser Trp Ser Ser Ala Pro Thr Ser Arg Ala
1345                1350                1355                1360
Ser Ser Pro Pro Pro Gln Pro Gln Pro Pro Pro Pro Ala Ala Arg Arg
                1365                1370                1375    
Leu Ser Tyr Ala Thr Thr Val Asn Ile His Val Gly Gly Gly Gly Arg
            1380                1385                1390        
Leu Arg Pro Ala Lys Ala Gln Val Arg Leu Asn His Pro Ala Leu Leu
        1395                1400                1405            
Ala Ser Thr Gln Glu Ser Met Gly Leu His Arg Ala Gln Gly Ala Pro
    1410                1415                1420                
Asp Ala Pro Phe His Met
1425                1430


<210> 1084
<211> 249
<212> PRT
<213> Homo sapiens

<400> 1084
Val Ile Lys Gly Gln Lys Tyr Glu Lys Arg Ile Glu Arg Leu Thr Ile
 1               5                  10                  15      
Arg Lys Glu Glu Asp Gly Asp Ala Gly Lys Glu Glu Asp Ala Arg Thr
            20                  25                  30          
Arg Ile Ile Arg Arg Ala Ala Leu Glu Phe Glu Asp Gly Met Tyr Ala
        35                  40                  45              
Asn Leu Gly Ile Gly Ile Pro Leu Leu Ala Ser Asn Phe Ile Ser Pro
    50                  55                  60                  
Ser Met Thr Val His Leu His Ser Glu Asn Gly Ile Leu Gly Leu Gly
65                  70                  75                  80  
Pro Phe Pro Thr Glu Asp Glu Val Asp Ala Asp Leu Ile Asn Ala Gly
                85                  90                  95      
Lys Gln Thr Val Thr Val Leu Pro Gly Gly Cys Phe Phe Ala Ser Asp
            100                 105                 110         
Asp Ser Phe Ala Met Ile Arg Gly Gly His Ile Gln Leu Thr Met Leu
        115                 120                 125             
Gly Ala Met Gln Val Ser Lys Tyr Gly Asp Leu Ala Asn Trp Met Ile
    130                 135                 140                 
Pro Gly Lys Lys Val Lys Gly Met Gly Gly Ala Met Asp Leu Val Ser
145                 150                 155                 160 
Ser Gln Lys Thr Arg Val Val Val Thr Met Gln His Cys Thr Lys Asp
                165                 170                 175     
Asn Thr Pro Lys Ile Met Glu Lys Cys Thr Met Pro Leu Thr Gly Lys
            180                 185                 190         
Arg Cys Val Asp Arg Ile Ile Thr Glu Lys Ala Val Phe Asp Val His
        195                 200                 205             
Arg Lys Lys Gly Leu Thr Leu Arg Glu Leu Trp Glu Gly Leu Thr Val
    210                 215                 220                 
Asp Asp Ile Lys Lys Ser Thr Gly Cys Ala Phe Ala Val Ser Pro Asn
225                 230                 235                 240 
Leu Arg Pro Met Gln Gln Val Ala Pro
                245                 


<210> 1085
<211> 1343
<212> PRT
<213> Homo sapiens

<400> 1085
Leu Arg Leu Ser Pro Pro Leu Leu Thr Asn Pro Ala Pro Ala Arg Pro
 1               5                  10                  15      
Ala Pro Arg Arg Gly Arg Ser Arg Ser Pro Ser Gly Gly Val Thr Met
            20                  25                  30          
Glu Glu Glu Asp Glu Ser Arg Gly Lys Thr Glu Glu Ser Gly Glu Asp
        35                  40                  45              
Arg Gly Asp Gly Pro Pro Asp Arg Asp Pro Thr Leu Ser Pro Ser Ala
    50                  55                  60                  
Phe Ile Leu Arg Ala Ile Gln Gln Ala Val Gly Ser Ser Leu Gln Gly
65                  70                  75                  80  
Asp Leu Pro Asn Asp Lys Asp Gly Ser Arg Cys His Gly Leu Arg Trp
                85                  90                  95      
Arg Arg Cys Arg Ser Pro Arg Ser Glu Pro Arg Ser Gln Glu Ser Gly
            100                 105                 110         
Gly Thr Asp Thr Ala Thr Val Leu Asp Met Ala Thr Asp Ser Phe Leu
        115                 120                 125             
Ala Gly Leu Val Ser Val Leu Asp Pro Pro Asp Thr Trp Val Pro Ser
    130                 135                 140                 
Arg Leu Asp Leu Arg Pro Gly Glu Ser Glu Asp Met Leu Glu Leu Val
145                 150                 155                 160 
Ala Glu Val Arg Ile Gly Asp Arg Asp Pro Ile Pro Leu Pro Val Pro
                165                 170                 175     
Ser Leu Leu Pro Arg Leu Arg Ala Trp Arg Thr Gly Lys Thr Val Ser
            180                 185                 190         
Pro Gln Ser Asn Ser Ser Arg Pro Thr Cys Ala Arg His Leu Thr Leu
        195                 200                 205             
Gly Thr Gly Asp Gly Gly Pro Ala Pro Pro Pro Ala Pro Ser Ser Ala
    210                 215                 220                 
Ser Ser Ser Pro Ser Pro Ser Pro Ser Ser Ser Ser Pro Ser Pro Pro
225                 230                 235                 240 
Pro Pro Pro Pro Pro Pro Ala Pro Pro Ala Pro Pro Ala Pro Arg Phe
                245                 250                 255     
Asp Ile Tyr Asp Pro Phe His Pro Thr Asp Glu Ala Tyr Ser Pro Pro
            260                 265                 270         
Pro Ala Pro Glu Gln Lys Tyr Asp Pro Phe Glu Pro Thr Gly Ser Asn
        275                 280                 285             
Pro Ser Ser Ser Ala Gly Thr Pro Ser Pro Glu Glu Glu Glu Glu Glu
    290                 295                 300                 
Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu Glu Gly
305                 310                 315                 320 
Leu Ser Gln Ser Ile Ser Arg Ile Ser Glu Thr Leu Ala Gly Ile Tyr
                325                 330                 335     
Asp Asp Asn Ser Leu Ser Gln Asp Phe Pro Gly Asp Glu Ser Pro Arg
            340                 345                 350         
Pro Asp Ala Gln Pro Thr Gln Pro Thr Pro Ala Pro Gly Thr Pro Pro
        355                 360                 365             
Gln Val Asp Ser Thr Arg Ala Asp Gly Ala Met Arg Arg Arg Val Phe
    370                 375                 380                 
Val Val Gly Thr Glu Ala Glu Ala Cys Arg Glu Gly Lys Val Ser Val
385                 390                 395                 400 
Glu Val Val Thr Ala Gly Gly Ala Ala Leu Pro Pro Pro Leu Leu Pro
                405                 410                 415     
Pro Gly Asp Ser Glu Ile Glu Glu Gly Glu Ile Val Gln Pro Glu Glu
            420                 425                 430         
Glu Pro Arg Leu Ala Leu Ser Leu Phe Arg Pro Gly Gly Arg Ala Ala
        435                 440                 445             
Arg Pro Pro Pro Ala Ala Ser Ala Thr Pro Thr Ala Gln Pro Leu Pro
    450                 455                 460                 
Gln Pro Pro Ala Pro Arg Ala Pro Glu Gly Asp Asp Phe Leu Ser Leu
465                 470                 475                 480 
His Ala Glu Ser Asp Gly Glu Gly Ala Leu Gln Val Asp Leu Gly Glu
                485                 490                 495     
Pro Ala Pro Ala Pro Pro Ala Ala Asp Ser Arg Trp Gly Gly Leu Asp
            500                 505                 510         
Leu Arg Arg Lys Ile Leu Thr Gln Arg Arg Glu Arg Tyr Arg Gln Arg
        515                 520                 525             
Ser Pro Ser Pro Ala Pro Ala Pro Ala Pro Ala Ala Ala Ala Gly Pro
    530                 535                 540                 
Pro Thr Arg Lys Lys Ser Arg Arg Glu Arg Lys Arg Ser Gly Glu Ala
545                 550                 555                 560 
Lys Glu Ala Ala Ser Ser Ser Ser Gly Thr Gln Pro Ala Pro Pro Ala
                565                 570                 575     
Pro Ala Ser Pro Trp Asp Ser Lys Lys His Arg Ser Arg Asp Arg Lys
            580                 585                 590         
Pro Gly Ser His Ala Ser Ser Ser Ala Arg Arg Arg Ser Arg Ser Arg
        595                 600                 605             
Ser Arg Ser Arg Ser Thr Arg Arg Arg Ser Arg Ser Thr Asp Arg Arg
    610                 615                 620                 
Arg Gly Gly Ser Arg Arg Ser Arg Ser Arg Glu Lys Arg Arg Arg Arg
625                 630                 635                 640 
Arg Arg Ser Ala Ser Pro Pro Pro Ala Thr Ser Ser Ser Ser Ser Ser
                645                 650                 655     
Arg Arg Glu Arg His Arg Gly Lys His Arg Asp Gly Gly Gly Ser Lys
            660                 665                 670         
Lys Lys Lys Lys Arg Ser Arg Ser Arg Gly Glu Lys Arg Ser Gly Asp
        675                 680                 685             
Gly Ser Glu Lys Ala Pro Ala Pro Ala Pro Pro Pro Ser Gly Ser Thr
    690                 695                 700                 
Ser Cys Gly Asp Arg Asp Ser Arg Arg Arg Gly Ala Val Pro Pro Ser
705                 710                 715                 720 
Ile Gln Asp Leu Thr Asp His Asp Leu Phe Ala Ile Lys Arg Thr Ile
                725                 730                 735     
Thr Val Gly Arg Leu Asp Lys Ser Asp Pro Arg Gly Pro Ser Pro Ala
            740                 745                 750         
Pro Ala Ser Ser Pro Lys Arg Glu Val Leu Tyr Asp Ser Glu Gly Leu
        755                 760                 765             
Ser Gly Glu Glu Arg Gly Gly Lys Ser Ser Gln Lys Asp Arg Arg Arg
    770                 775                 780                 
Ser Gly Ala Ala Ser Ser Ser Ser Ser Ser Arg Glu Lys Gly Ser Arg
785                 790                 795                 800 
Arg Lys Ala Leu Asp Gly Gly Asp Arg Asp Arg Asp Arg Asp Arg Asp
                805                 810                 815     
Arg Asp Arg Asp Arg Ser Ser Lys Lys Ala Arg Pro Pro Lys Glu Ser
            820                 825                 830         
Ala Pro Ser Ser Gly Pro Pro Pro Lys Pro Pro Val Ser Ser Gly Ser
        835                 840                 845             
Gly Ser Ser Ser Ser Ser Ser Ser Cys Ser Ser Arg Lys Val Lys Leu
    850                 855                 860                 
Gln Ser Lys Val Ala Val Leu Ile Arg Glu Gly Val Ser Ser Thr Thr
865                 870                 875                 880 
Pro Ala Lys Asp Ala Ala Ser Ala Gly Leu Gly Ser Ile Gly Val Lys
                885                 890                 895     
Phe Ser Arg Asp Arg Glu Ser Arg Ser Pro Phe Leu Lys Pro Asp Glu
            900                 905                 910         
Arg Ala Pro Thr Glu Met Ala Lys Ala Ala Pro Gly Ser Thr Lys Pro
        915                 920                 925             
Lys Lys Thr Lys Val Lys Ala Lys Ala Gly Ala Lys Lys Thr Lys Gly
    930                 935                 940                 
Thr Lys Gly Lys Thr Lys Pro Ser Lys Thr Arg Lys Lys Val Arg Ser
945                 950                 955                 960 
Gly Gly Gly Ser Gly Gly Ser Gly Gly Gln Val Ser Leu Lys Lys Ser
                965                 970                 975     
Lys Ala Asp Ser Cys Ser Gln Ala Ala Gly Thr Lys Gly Ala Glu Glu
            980                 985                 990         
Thr Ser Trp Ser Gly Glu Glu Arg Ala Ala Lys Val Pro Ser Thr Pro
        995                 1000                1005            
Pro Pro Lys Ala Ala Pro Pro Pro Pro Ala Leu Thr Pro Asp Ser Gln
    1010                1015                1020                
Thr Val Asp Ser Ser Cys Lys Thr Pro Glu Val Ser Phe Leu Pro Glu
1025                1030                1035                1040
Glu Ala Thr Glu Glu Ala Gly Val Arg Gly Gly Ala Glu Glu Glu Glu
                1045                1050                1055    
Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Gln Gln
            1060                1065                1070        
Pro Ala Thr Thr Thr Ala Thr Ser Thr Ala Ala Ala Ala Pro Ser Thr
        1075                1080                1085            
Ala Pro Ser Ala Gly Ser Thr Ala Gly Asp Ser Gly Ala Glu Asp Gly
    1090                1095                1100                
Pro Ala Ser Arg Val Ser Gln Leu Pro Thr Leu Pro Pro Pro Met Pro
1105                1110                1115                1120
Trp Asn Leu Pro Ala Gly Val Asp Cys Thr Thr Ser Gly Val Leu Ala
                1125                1130                1135    
Leu Thr Ala Leu Leu Phe Lys Met Glu Glu Ala Asn Leu Ala Ser Arg
            1140                1145                1150        
Ala Lys Ala Gln Glu Leu Ile Gln Ala Thr Asn Gln Ile Leu Ser His
        1155                1160                1165            
Arg Lys Pro Pro Ser Ser Leu Gly Met Thr Pro Ala Pro Val Pro Thr
    1170                1175                1180                
Ser Leu Gly Leu Pro Pro Gly Pro Ser Ser Tyr Leu Leu Pro Gly Ser
1185                1190                1195                1200
Leu Pro Leu Gly Gly Cys Gly Ser Thr Pro Pro Thr Pro Thr Gly Leu
                1205                1210                1215    
Ala Ala Thr Ser Asp Lys Arg Glu Gly Ser Ser Ser Ser Glu Gly Arg
            1220                1225                1230        
Gly Asp Thr Asp Lys Tyr Leu Lys Lys Leu His Thr Gln Glu Arg Ala
        1235                1240                1245            
Val Glu Glu Val Lys Leu Ala Ile Lys Pro Tyr Tyr Gln Lys Lys Asp
    1250                1255                1260                
Ile Thr Lys Glu Glu Tyr Lys Asp Ile Leu Arg Lys Ala Val His Lys
1265                1270                1275                1280
Ile Cys His Ser Lys Ser Gly Glu Ile Asn Pro Val Lys Val Ser Asn
                1285                1290                1295    
Leu Val Arg Ala Tyr Val Gln Arg Tyr Arg Tyr Phe Arg Lys His Gly
            1300                1305                1310        
Arg Lys Pro Gly Asp Pro Pro Gly Pro Pro Arg Pro Pro Lys Glu Pro
        1315                1320                1325            
Gly Pro Pro Asp Lys Gly Gly Pro Gly Leu Pro Leu Pro Pro Leu
    1330                1335                1340            


<210> 1086
<211> 641
<212> PRT
<213> Homo sapiens

<400> 1086
Gly Ala Arg Arg Ala Leu Gly Val Leu Gly Gln Pro Gly Gly Leu Gln
 1               5                  10                  15      
Met Arg Leu Pro Glu Arg His Gly Gly Pro Gln Gly Ser Leu Cys Leu
            20                  25                  30          
Met Asp Pro Cys Cys Pro Leu Ser Leu Ala Leu Gln Asp Leu Val Glu
        35                  40                  45              
Arg Asp Cys Asn Gly Asp Thr Pro Asn Leu Ser Phe Tyr Arg Asn Glu
    50                  55                  60                  
Ile Arg Phe Leu Pro Asn Gly Cys Phe Ile Glu Asp Ile Leu Gln Asn
65                  70                  75                  80  
Trp Thr Asp Asn Tyr Asp Leu Leu Glu Asp Asn His Ser Tyr Ile Gln
                85                  90                  95      
Trp Leu Phe Pro Leu Arg Glu Pro Gly Val Asn Trp His Ala Lys Pro
            100                 105                 110         
Leu Thr Leu Arg Glu Val Glu Val Phe Lys Ser Ser Gln Glu Ile Gln
        115                 120                 125             
Glu Arg Leu Val Arg Ala Tyr Glu Leu Met Leu Gly Phe Tyr Gly Ile
    130                 135                 140                 
Arg Leu Glu Asp Arg Gly Thr Gly Thr Val Gly Arg Ala Gln Asn Tyr
145                 150                 155                 160 
Gln Lys Arg Phe Gln Asn Leu Asn Trp Arg Ser His Asn Asn Leu Arg
                165                 170                 175     
Ile Thr Arg Ile Leu Lys Ser Leu Gly Glu Leu Gly Leu Glu His Phe
            180                 185                 190         
Gln Ala Pro Leu Val Arg Phe Phe Leu Glu Glu Thr Leu Val Arg Arg
        195                 200                 205             
Glu Leu Pro Gly Val Arg Gln Ser Ala Leu Asp Tyr Phe Met Phe Ala
    210                 215                 220                 
Val Arg Cys Arg His Gln Arg Arg Gln Leu Val His Phe Ala Trp Glu
225                 230                 235                 240 
His Phe Arg Pro Arg Cys Lys Phe Val Trp Gly Pro Gln Asp Lys Leu
                245                 250                 255     
Arg Arg Phe Lys Pro Ser Ser Leu Pro His Pro Leu Glu Gly Ser Arg
            260                 265                 270         
Lys Val Glu Glu Glu Gly Ser Pro Gly Asp Pro Asp His Glu Ala Ser
        275                 280                 285             
Thr Gln Gly Arg Thr Cys Gly Pro Glu His Ser Lys Gly Gly Gly Arg
    290                 295                 300                 
Val Asp Glu Gly Pro Gln Pro Arg Ser Val Glu Pro Gln Asp Ala Gly
305                 310                 315                 320 
Pro Leu Glu Arg Ser Gln Gly Asp Glu Ala Gly Gly His Gly Glu Asp
                325                 330                 335     
Arg Pro Glu Pro Leu Ser Pro Lys Glu Ser Lys Lys Arg Lys Leu Glu
            340                 345                 350         
Leu Ser Arg Arg Glu Gln Pro Pro Thr Glu Pro Gly Pro Gln Ser Ala
        355                 360                 365             
Ser Glu Val Glu Lys Ile Ala Leu Asn Leu Glu Gly Cys Ala Leu Ser
    370                 375                 380                 
Gln Gly Ser Leu Arg Thr Gly Thr Gln Glu Val Gly Gly Gln Asp Pro
385                 390                 395                 400 
Gly Glu Ala Val Gln Pro Cys Arg Gln Pro Leu Gly Ala Arg Val Ala
                405                 410                 415     
Asp Lys Val Arg Lys Arg Arg Lys Val Asp Glu Gly Ala Gly Asp Ser
            420                 425                 430         
Ala Ala Val Ala Ser Gly Gly Ala Gln Thr Leu Ala Leu Ala Gly Ser
        435                 440                 445             
Pro Ala Pro Ser Gly His Pro Lys Ala Gly His Ser Glu Asn Gly Val
    450                 455                 460                 
Glu Glu Asp Thr Glu Gly Arg Thr Gly Pro Lys Glu Gly Thr Pro Gly
465                 470                 475                 480 
Ser Pro Ser Glu Thr Pro Gly Pro Ser Pro Ala Gly Pro Ala Gly Asp
                485                 490                 495     
Glu Pro Ala Glu Ser Pro Ser Glu Thr Pro Gly Pro Arg Pro Ala Gly
            500                 505                 510         
Pro Ala Gly Asp Glu Pro Ala Glu Ser Pro Ser Glu Thr Pro Gly Pro
        515                 520                 525             
Arg Pro Ala Gly Pro Ala Gly Asp Glu Pro Ala Lys Thr Pro Ser Glu
    530                 535                 540                 
Thr Pro Gly Pro Ser Pro Ala Gly Pro Thr Arg Asp Glu Pro Ala Glu
545                 550                 555                 560 
Ser Pro Ser Glu Thr Pro Gly Pro Arg Pro Ala Gly Pro Ala Gly Asp
                565                 570                 575     
Glu Pro Ala Glu Ser Pro Ser Glu Thr Pro Gly Pro Arg Pro Ala Gly
            580                 585                 590         
Pro Ala Gly Asp Glu Pro Ala Glu Ser Pro Ser Glu Thr Pro Gly Pro
        595                 600                 605             
Ser Pro Ala Gly Pro Thr Arg Asp Glu Pro Ala Lys Ala Gly Glu Ala
    610                 615                 620                 
Ala Glu Leu Gln Asp Ala Glu Val Glu Ser Ser Ala Lys Ser Gly Lys
625                 630                 635                 640 
Pro
    


<210> 1087
<211> 237
<212> PRT
<213> Homo sapiens

<400> 1087
Met Gly Pro Cys Thr Thr Ala Trp Phe His Ser Asp Trp Ser Ser Lys
 1               5                  10                  15      
Cys Ser Ala Glu Cys Gly Thr Gly Ile Gln Arg Arg Ser Val Val Cys
            20                  25                  30          
Leu Gly Ser Gly Ala Ala Leu Gly Pro Gly Gln Gly Glu Ala Gly Ala
        35                  40                  45              
Gly Thr Gly Gln Ser Cys Pro Thr Gly Ser Arg Pro Pro Asp Met Arg
    50                  55                  60                  
Ala Cys Ser Leu Gly Pro Cys Glu Arg Thr Trp Arg Trp Tyr Thr Gly
65                  70                  75                  80  
Pro Trp Gly Glu Cys Ser Ser Glu Cys Gly Ser Gly Thr Gln Arg Arg
                85                  90                  95      
Asp Ile Ile Cys Val Ser Lys Leu Gly Thr Glu Phe Asn Val Thr Ser
            100                 105                 110         
Pro Ser Asn Cys Ser His Leu Pro Arg Pro Pro Ala Leu Gln Pro Cys
        115                 120                 125             
Gln Gly Gln Ala Cys Gln Asp Arg Trp Phe Ser Thr Pro Trp Ser Pro
    130                 135                 140                 
Cys Ser Arg Ser Cys Gln Gly Gly Thr Gln Thr Arg Glu Val Gln Cys
145                 150                 155                 160 
Leu Ser Thr Asn Gln Thr Leu Ser Thr Arg Cys Pro Pro Gln Leu Arg
                165                 170                 175     
Pro Ser Arg Lys Arg Pro Cys Asn Ser Gln Pro Cys Ser Gln Arg Pro
            180                 185                 190         
Asp Asp Gln Cys Lys Asp Ser Ser Pro His Cys Pro Leu Val Val Gln
        195                 200                 205             
Ala Arg Leu Cys Val Tyr Pro Tyr Tyr Thr Ala Thr Cys Cys Arg Ser
    210                 215                 220                 
Cys Ala His Val Leu Glu Arg Ser Pro Gln Asp Pro Ser
225                 230                 235         


<210> 1088
<211> 272
<212> PRT
<213> Homo sapiens

<400> 1088
Met Ser Val Gly Phe Ile Gly Ala Gly Gln Leu Ala Phe Ala Leu Ala
 1               5                  10                  15      
Lys Gly Phe Thr Ala Ala Gly Val Leu Ala Ala His Lys Ile Met Ala
            20                  25                  30          
Ser Ser Pro Asp Met Asp Leu Ala Thr Val Ser Ala Leu Arg Lys Met
        35                  40                  45              
Gly Val Lys Leu Thr Pro His Asn Lys Glu Thr Val Gln His Ser Asp
    50                  55                  60                  
Val Leu Phe Leu Ala Val Lys Pro His Ile Ile Pro Phe Ile Leu Asp
65                  70                  75                  80  
Glu Ile Gly Ala Asp Ile Glu Asp Arg His Ile Val Val Ser Cys Ala
                85                  90                  95      
Ala Gly Val Thr Ile Ser Ser Ile Glu Lys Lys Leu Ser Ala Phe Arg
            100                 105                 110         
Pro Ala Pro Arg Val Ile Arg Cys Met Thr Asn Thr Pro Val Val Val
        115                 120                 125             
Arg Glu Gly Ala Thr Val Tyr Ala Thr Gly Thr His Ala Gln Val Glu
    130                 135                 140                 
Asp Gly Arg Leu Met Glu Gln Leu Leu Ser Ser Val Gly Phe Cys Thr
145                 150                 155                 160 
Glu Val Glu Glu Asp Leu Ile Asp Ala Val Thr Gly Leu Ser Gly Ser
                165                 170                 175     
Gly Pro Ala Tyr Ala Phe Thr Ala Leu Asp Ala Leu Ala Asp Gly Gly
            180                 185                 190         
Val Lys Met Gly Leu Pro Arg Arg Leu Ala Val Arg Leu Gly Ala Gln
        195                 200                 205             
Ala Leu Leu Gly Ala Cys Gln Asp Ala Ala Ala Leu Arg Thr Ala Pro
    210                 215                 220                 
Arg Pro Ala Gln Gly Gln Arg Gln Leu Ser Trp Trp Gly His His Pro
225                 230                 235                 240 
Cys Leu Ala Cys Ala Gly Glu Trp Gly Leu Pro Leu Pro Ala His Gln
                245                 250                 255     
Arg Cys Gly Gly Leu Leu His Pro His Thr Gly Ala Ala Val His Gly
            260                 265                 270         


<210> 1089
<211> 324
<212> PRT
<213> Homo sapiens

<400> 1089
Met Arg Phe Thr Phe Pro Leu Met Ala Ile Val Leu Glu Ile Ala Met
 1               5                  10                  15      
Ile Val Leu Phe Gly Leu Phe Val Glu Tyr Glu Thr Asp Gln Thr Val
            20                  25                  30          
Leu Glu Gln Leu Asn Ile Thr Lys Pro Thr Asp Met Gly Ile Phe Phe
        35                  40                  45              
Glu Leu Tyr Pro Leu Phe Gln Asp Val His Val Met Ile Phe Val Gly
    50                  55                  60                  
Phe Gly Phe Leu Met Thr Phe Leu Lys Lys Tyr Gly Phe Ser Ser Val
65                  70                  75                  80  
Gly Ile Asn Leu Leu Val Ala Ala Leu Gly Leu Gln Trp Gly Thr Ile
                85                  90                  95      
Val Gln Gly Ile Leu Gln Ser Gln Gly Gln Lys Phe Asn Ile Gly Ile
            100                 105                 110         
Lys Asn Met Ile Asn Ala Asp Phe Ser Ala Ala Thr Val Leu Ile Ser
        115                 120                 125             
Phe Gly Ala Val Leu Gly Lys Thr Ser Pro Thr Gln Met Leu Ile Met
    130                 135                 140                 
Thr Ile Leu Glu Ile Val Phe Phe Ala His Asn Glu Tyr Leu Val Ser
145                 150                 155                 160 
Glu Ile Phe Lys Ala Ser Asp Ile Gly Ala Ser Met Thr Ile His Ala
                165                 170                 175     
Phe Gly Ala Tyr Phe Gly Leu Ala Val Ala Gly Ile Leu Tyr Arg Ser
            180                 185                 190         
Gly Leu Arg Lys Gly His Glu Asn Glu Glu Ser Ala Tyr Tyr Ser Asp
        195                 200                 205             
Leu Phe Ala Met Ile Gly Thr Leu Phe Leu Trp Met Phe Trp Pro Ser
    210                 215                 220                 
Phe Asn Ser Ala Ile Ala Glu Pro Gly Asp Lys Gln Cys Arg Ala Ile
225                 230                 235                 240 
Val Asn Thr Tyr Phe Ser Leu Ala Ala Cys Val Leu Thr Ala Phe Ala
                245                 250                 255     
Phe Ser Ser Leu Val Glu His Arg Gly Lys Leu Asn Met Val His Ile
            260                 265                 270         
Gln Asn Ala Thr Leu Ala Gly Gly Val Ala Val Gly Thr Cys Ala Asp
        275                 280                 285             
Met Ala Ile His Pro Phe Gly Ser Met Ile Ile Gly Ser Ile Ala Gly
    290                 295                 300                 
Met Val Ser Val Leu Gly Tyr Lys Phe Leu Thr Pro Leu Phe Thr Thr
305                 310                 315                 320 
Lys Leu Arg Ile
                


<210> 1090
<211> 278
<212> PRT
<213> Homo sapiens

<400> 1090
Met Phe Phe Phe Ser Arg Leu Glu Tyr Leu Lys Glu Leu Pro Val Asp
 1               5                  10                  15      
Lys Leu Lys Gly Val Ser Leu Ile Lys Val Lys Phe Glu Asp Ile Lys
            20                  25                  30          
Asp Trp Ser Asp Leu Val Thr Pro Gln Gly Ile Met Gly Ile Phe Ala
        35                  40                  45              
Lys Pro Asp His Val Lys Met Thr Tyr Pro Lys Thr Gln Leu Gln His
    50                  55                  60                  
Ser Leu Pro Leu Leu Leu Ile Cys Asp Asn Leu Arg Asp Pro Gly Asn
65                  70                  75                  80  
Leu Gly Thr Ile Leu Arg Ser Ala Ala Gly Ala Gly Cys Ser Lys Val
                85                  90                  95      
Leu Leu Thr Lys Gly Cys Val Asp Ala Trp Glu Pro Lys Val Leu Arg
            100                 105                 110         
Ala Gly Met Gly Ala His Phe Arg Met Pro Ile Ile Asn Asn Leu Glu
        115                 120                 125             
Trp Glu Thr Val Pro Asn Tyr Leu Pro Pro Asp Thr Arg Val Tyr Val
    130                 135                 140                 
Ala Asp Asn Cys Gly Leu Tyr Ala Gln Ala Glu Met Ser Asn Lys Ala
145                 150                 155                 160 
Ser Asp His Gly Trp Val Cys Asp Gln Arg Val Met Lys Phe His Lys
                165                 170                 175     
Tyr Glu Glu Glu Glu Asp Val Glu Thr Gly Ala Ser Gln Asp Trp Leu
            180                 185                 190         
Pro His Val Glu Val Gln Ser Tyr Asp Ser Asp Trp Thr Glu Ala Pro
        195                 200                 205             
Ala Ala Val Val Ile Gly Gly Glu Thr Tyr Gly Val Ser Leu Glu Ser
    210                 215                 220                 
Leu Gln Leu Ala Glu Ser Thr Gly Gly Lys Arg Leu Leu Ile Pro Val
225                 230                 235                 240 
Val Pro Gly Val Asp Ser Leu Asn Ser Ala Met Ala Ala Ser Ile Leu
                245                 250                 255     
Leu Phe Glu Gly Lys Arg Gln Leu Arg Gly Arg Ala Glu Asp Leu Ser
            260                 265                 270         
Arg Asp Arg Ser Tyr His
        275             


<210> 1091
<211> 370
<212> PRT
<213> Homo sapiens

<400> 1091
Met Ala Val Ser Val Thr Pro Ile Arg Asp Thr Lys Trp Leu Thr Leu
 1               5                  10                  15      
Glu Val Cys Arg Glu Phe Gln Arg Gly Thr Cys Ser Arg Pro Asp Thr
            20                  25                  30          
Glu Cys Lys Phe Ala His Pro Ser Lys Ser Cys Gln Val Glu Asn Gly
        35                  40                  45              
Arg Val Ile Ala Cys Phe Asp Ser Leu Lys Gly Arg Cys Ser Arg Glu
    50                  55                  60                  
Asn Cys Lys Tyr Leu His Pro Pro Pro His Leu Lys Thr Gln Leu Glu
65                  70                  75                  80  
Ile Asn Gly Arg Asn Asn Leu Ile Gln Gln Lys Asn Met Ala Met Leu
                85                  90                  95      
Ala Gln Gln Met Gln Leu Ala Asn Ala Met Met Pro Gly Ala Pro Leu
            100                 105                 110         
Gln Pro Val Pro Met Phe Ser Val Ala Pro Ser Leu Ala Thr Asn Ala
        115                 120                 125             
Ser Ala Ala Ala Phe Asn Pro Tyr Leu Gly Pro Val Ser Pro Ser Leu
    130                 135                 140                 
Val Pro Ala Glu Ile Leu Pro Thr Ala Pro Met Leu Val Thr Gly Asn
145                 150                 155                 160 
Pro Gly Val Pro Val Pro Ala Ala Ala Ala Ala Ala Ala Gln Lys Leu
                165                 170                 175     
Met Arg Thr Asp Arg Leu Glu Val Cys Arg Glu Tyr Gln Arg Gly Asn
            180                 185                 190         
Cys Asn Arg Gly Glu Asn Asp Cys Arg Phe Ala His Pro Ala Asp Ser
        195                 200                 205             
Thr Met Ile Asp Thr Asn Asp Asn Thr Val Thr Val Cys Met Asp Tyr
    210                 215                 220                 
Ile Lys Gly Arg Cys Ser Arg Glu Lys Cys Lys Tyr Phe His Pro Pro
225                 230                 235                 240 
Ala His Leu Gln Ala Lys Ile Lys Ala Ala Gln Tyr Gln Val Asn Gln
                245                 250                 255     
Ala Ala Ala Ala Gln Ala Ala Ala Thr Ala Ala Ala Met Gly Ile Pro
            260                 265                 270         
Gln Ala Val Leu Pro Pro Leu Pro Lys Arg Pro Ala Leu Glu Lys Thr
        275                 280                 285             
Asn Gly Ala Thr Ala Val Phe Asn Thr Gly Ile Phe Gln Tyr Gln Gln
    290                 295                 300                 
Ala Leu Ala Asn Met Gln Leu Gln Gln His Thr Ala Phe Leu Pro Pro
305                 310                 315                 320 
Val Pro Met Val His Gly Ala Thr Pro Ala Thr Val Ser Ala Ala Thr
                325                 330                 335     
Thr Ser Ala Thr Ser Val Pro Phe Ala Ala Thr Ala Thr Ala Asn Gln
            340                 345                 350         
Ile Pro Ile Ile Ser Ala Glu His Leu Thr Ser His Lys Tyr Val Thr
        355                 360                 365             
Gln Met
    370 


<210> 1092
<211> 1056
<212> PRT
<213> Homo sapiens

<400> 1092
Met Glu Val Ala Glu Val Glu Ser Pro Leu Asn Pro Ser Cys Lys Ile
 1               5                  10                  15      
Met Thr Phe Arg Pro Ser Met Glu Glu Phe Arg Glu Phe Asn Lys Tyr
            20                  25                  30          
Leu Ala Tyr Met Glu Ser Lys Gly Ala His Arg Ala Gly Leu Ala Lys
        35                  40                  45              
Val Ile Pro Pro Lys Glu Trp Lys Pro Arg Gln Cys Tyr Asp Asp Ile
    50                  55                  60                  
Asp Asn Leu Leu Ile Pro Ala Pro Ile Gln Gln Met Val Thr Gly Gln
65                  70                  75                  80  
Ser Gly Leu Phe Thr Gln Tyr Asn Ile Gln Lys Lys Ala Met Thr Val
                85                  90                  95      
Lys Glu Phe Arg Gln Leu Ala Asn Ser Gly Lys Tyr Cys Thr Pro Arg
            100                 105                 110         
Tyr Leu Asp Tyr Glu Asp Leu Glu Arg Lys Tyr Trp Lys Asn Leu Thr
        115                 120                 125             
Phe Val Ala Pro Ile Tyr Gly Ala Asp Ile Asn Gly Ser Ile Tyr Asp
    130                 135                 140                 
Glu Gly Val Asp Glu Trp Asn Ile Ala Arg Ile Asn Thr Val Leu Asp
145                 150                 155                 160 
Val Val Glu Glu Glu Cys Gly Ile Ser Ile Glu Gly Val Asn Thr Pro
                165                 170                 175     
Tyr Leu Tyr Phe Gly Met Trp Lys Thr Thr Phe Ala Trp His Thr Glu
            180                 185                 190         
Asp Met Asp Leu Tyr Ser Ile Asn Tyr Leu His Phe Gly Glu Pro Lys
        195                 200                 205             
Ser Trp Tyr Ala Ile Pro Pro Glu His Gly Lys Arg Leu Glu Arg Leu
    210                 215                 220                 
Ala Gln Gly Phe Phe Pro Ser Ser Ser Gln Gly Cys Asp Ala Phe Leu
225                 230                 235                 240 
Arg His Lys Met Thr Leu Ile Ser Pro Ser Val Leu Lys Lys Tyr Gly
                245                 250                 255     
Ile Pro Phe Asp Lys Ile Thr Gln Glu Ala Gly Glu Phe Met Ile Thr
            260                 265                 270         
Phe Pro Tyr Gly Tyr His Ala Gly Phe Asn His Gly Phe Asn Cys Ala
        275                 280                 285             
Glu Ser Thr Asn Phe Ala Thr Val Arg Trp Ile Asp Tyr Gly Lys Val
    290                 295                 300                 
Ala Lys Leu Cys Thr Cys Arg Lys Asp Met Val Lys Ile Ser Met Asp
305                 310                 315                 320 
Ile Phe Val Arg Lys Phe Gln Pro Asp Arg Tyr Gln Leu Trp Lys Gln
                325                 330                 335     
Gly Lys Asp Ile Tyr Thr Ile Asp His Thr Lys Pro Thr Pro Ala Ser
            340                 345                 350         
Thr Pro Glu Val Lys Ala Trp Leu Gln Arg Arg Arg Lys Val Arg Lys
        355                 360                 365             
Ala Ser Arg Ser Phe Gln Cys Ala Arg Ser Thr Ser Lys Arg Pro Lys
    370                 375                 380                 
Ala Asp Glu Glu Glu Glu Val Ser Asp Glu Val Asp Gly Ala Glu Val
385                 390                 395                 400 
Pro Asn Pro Asp Ser Val Thr Asp Asp Leu Lys Val Ser Glu Lys Ser
                405                 410                 415     
Glu Ala Ala Val Lys Leu Arg Asn Thr Glu Ala Ser Ser Glu Glu Glu
            420                 425                 430         
Ser Ser Ala Ser Arg Met Gln Val Glu Gln Asn Leu Ser Asp His Ile
        435                 440                 445             
Lys Leu Ser Gly Asn Ser Cys Leu Ser Thr Ser Val Thr Glu Asp Ile
    450                 455                 460                 
Lys Thr Glu Asp Asp Lys Ala Tyr Ala Tyr Arg Ser Val Pro Ser Ile
465                 470                 475                 480 
Ser Ser Glu Ala Asp Asp Ser Ile Pro Leu Ser Thr Gly Tyr Glu Lys
                485                 490                 495     
Pro Glu Lys Ser Asp Pro Ser Glu Leu Ser Trp Pro Lys Ser Pro Glu
            500                 505                 510         
Ser Cys Ser Ser Val Ala Glu Ser Asn Gly Val Leu Thr Glu Gly Glu
        515                 520                 525             
Glu Ser Asp Val Glu Ser His Gly Asn Gly Leu Glu Pro Gly Glu Ile
    530                 535                 540                 
Pro Ala Val Pro Ser Gly Glu Arg Asn Ser Phe Lys Val Pro Ser Ile
545                 550                 555                 560 
Ala Glu Gly Glu Asn Lys Thr Ser Lys Ser Trp Arg His Pro Leu Ser
                565                 570                 575     
Arg Pro Pro Ala Arg Ser Pro Met Thr Leu Val Lys Gln Gln Ala Pro
            580                 585                 590         
Ser Asp Glu Glu Leu Pro Glu Val Leu Ser Ile Glu Glu Glu Val Glu
        595                 600                 605             
Glu Thr Glu Ser Trp Ala Lys Pro Leu Ile His Leu Trp Gln Thr Lys
    610                 615                 620                 
Ser Pro Asn Phe Ala Ala Glu Gln Glu Tyr Asn Ala Thr Val Ala Arg
625                 630                 635                 640 
Met Lys Pro His Cys Ala Ile Cys Thr Leu Leu Met Pro Tyr His Lys
                645                 650                 655     
Pro Asp Ser Ser Asn Glu Glu Asn Asp Ala Arg Trp Glu Thr Lys Leu
            660                 665                 670         
Asp Glu Val Val Thr Ser Glu Gly Lys Thr Lys Pro Leu Ile Pro Glu
        675                 680                 685             
Met Cys Phe Ile Tyr Ser Glu Glu Asn Ile Glu Tyr Ser Pro Pro Asn
    690                 695                 700                 
Ala Phe Leu Glu Glu Asp Gly Thr Ser Leu Leu Ile Ser Cys Ala Lys
705                 710                 715                 720 
Cys Cys Val Arg Val His Ala Ser Cys Tyr Gly Ile Pro Ser His Glu
                725                 730                 735     
Ile Cys Asp Gly Trp Leu Cys Ala Arg Cys Lys Arg Asn Ala Trp Thr
            740                 745                 750         
Ala Glu Cys Cys Leu Cys Asn Leu Arg Gly Gly Ala Leu Lys Gln Thr
        755                 760                 765             
Lys Asn Asn Arg Trp Ala His Val Met Cys Ala Val Ala Val Pro Glu
    770                 775                 780                 
Val Arg Phe Thr Asn Val Pro Glu Arg Thr Gln Ile Asp Val Gly Arg
785                 790                 795                 800 
Ile Pro Leu Gln Arg Leu Lys Leu Lys Cys Ile Phe Cys Arg His Arg
                805                 810                 815     
Val Lys Arg Val Ser Gly Ala Cys Ile Gln Cys Ser Tyr Gly Arg Cys
            820                 825                 830         
Pro Ala Ser Phe His Val Thr Cys Ala His Ala Ala Gly Val Leu Met
        835                 840                 845             
Glu Pro Asp Asp Trp Pro Tyr Val Val Asn Ile Thr Cys Phe Arg His
    850                 855                 860                 
Lys Val Asn Pro Asn Val Lys Ser Lys Ala Cys Glu Lys Val Ile Ser
865                 870                 875                 880 
Val Gly Gln Thr Val Ile Thr Lys His Arg Asn Thr Arg Tyr Tyr Ser
                885                 890                 895     
Cys Arg Val Met Ala Val Thr Ser Gln Thr Phe Tyr Glu Val Met Phe
            900                 905                 910         
Asp Asp Gly Ser Phe Ser Arg Asp Thr Phe Pro Glu Asp Ile Val Ser
        915                 920                 925             
Arg Asp Cys Leu Lys Leu Gly Pro Pro Ala Glu Gly Glu Val Val Gln
    930                 935                 940                 
Val Lys Trp Pro Asp Gly Lys Leu Tyr Gly Ala Lys Tyr Phe Gly Ser
945                 950                 955                 960 
Asn Ile Ala His Met Tyr Gln Val Glu Phe Glu Asp Gly Ser Gln Ile
                965                 970                 975     
Ala Met Lys Arg Glu Asp Ile Tyr Thr Leu Asp Glu Glu Leu Pro Lys
            980                 985                 990         
Arg Val Lys Ala Arg Phe Ser Thr Ala Ser Asp Met Arg Phe Glu Asp
        995                 1000                1005            
Thr Phe Tyr Gly Ala Asp Ile Ile Gln Gly Glu Arg Lys Arg Gln Arg
    1010                1015                1020                
Val Leu Ser Ser Arg Phe Lys Asn Glu Tyr Val Ala Asp Pro Val Tyr
1025                1030                1035                1040
Arg Thr Phe Leu Lys Ser Ser Phe Gln Lys Lys Cys Gln Lys Arg Gln
                1045                1050                1055    


<210> 1093
<211> 71
<212> PRT
<213> Homo sapiens

<400> 1093
Ile Arg Leu Asn Ser Arg Gly Leu Ile Tyr Ser Val Gly Leu Leu Leu
 1               5                  10                  15      
Ala Ser Val Phe Val Thr Val Phe Gly Val His Leu Asn Lys Trp Gln
            20                  25                  30          
Leu Asp Lys Lys Leu Gly Cys Gly Cys Leu Leu Leu Tyr Gly Val Phe
        35                  40                  45              
Leu Cys Phe Ser Ile Met Thr Glu Phe Asn Val Phe Thr Phe Val Asn
    50                  55                  60                  
Leu Pro Met Cys Gly Asp His
65                  70      


<210> 1094
<211> 997
<212> PRT
<213> Homo sapiens

<400> 1094
Met Pro Gly Gly Pro Ser Pro Arg Ser Pro Ala Pro Leu Leu Arg Pro
 1               5                  10                  15      
Leu Leu Leu Leu Leu Cys Ala Leu Ala Pro Gly Ala Pro Gly Pro Ala
            20                  25                  30          
Pro Gly Arg Ala Thr Glu Gly Arg Ala Ala Leu Asp Ile Val His Pro
        35                  40                  45              
Val Arg Val Asp Ala Gly Gly Ser Phe Leu Ser Tyr Glu Leu Trp Pro
    50                  55                  60                  
Arg Ala Leu Arg Lys Arg Asp Val Ser Val Arg Arg Asp Ala Pro Ala
65                  70                  75                  80  
Phe Tyr Glu Leu Gln Tyr Arg Gly Arg Glu Leu Arg Phe Asn Leu Thr
                85                  90                  95      
Ala Asn Gln His Leu Leu Ala Pro Gly Phe Val Ser Glu Thr Arg Arg
            100                 105                 110         
Arg Gly Gly Leu Gly Arg Ala His Ile Arg Ala His Thr Pro Ala Cys
        115                 120                 125             
His Leu Leu Gly Glu Val Gln Asp Pro Glu Leu Glu Gly Gly Leu Ala
    130                 135                 140                 
Ala Ile Ser Ala Cys Asp Gly Leu Lys Gly Val Phe Gln Leu Ser Asn
145                 150                 155                 160 
Glu Asp Tyr Phe Ile Glu Pro Leu Asp Ser Ala Pro Ala Arg Pro Gly
                165                 170                 175     
His Ala Gln Pro His Val Val Tyr Lys Arg Gln Ala Pro Glu Arg Leu
            180                 185                 190         
Ala Gln Arg Gly Asp Ser Ser Ala Pro Ser Thr Cys Gly Val Gln Val
        195                 200                 205             
Tyr Pro Glu Leu Glu Ser Arg Arg Glu Arg Trp Glu Gln Arg Gln Gln
    210                 215                 220                 
Trp Arg Arg Pro Arg Leu Arg Arg Leu His Gln Arg Ser Val Ser Lys
225                 230                 235                 240 
Glu Lys Trp Val Glu Thr Leu Val Val Ala Asp Ala Lys Met Val Glu
                245                 250                 255     
Tyr His Gly Gln Pro Gln Val Glu Ser Tyr Val Leu Thr Ile Met Asn
            260                 265                 270         
Met Val Ala Gly Leu Phe His Asp Pro Ser Ile Gly Asn Pro Ile His
        275                 280                 285             
Ile Thr Ile Val Arg Leu Val Leu Leu Glu Asp Glu Glu Glu Asp Leu
    290                 295                 300                 
Lys Ile Thr His His Ala Asp Asn Thr Leu Lys Ser Phe Cys Lys Trp
305                 310                 315                 320 
Gln Lys Ser Ile Asn Met Lys Gly Asp Ala His Pro Leu His His Asp
                325                 330                 335     
Thr Ala Ile Leu Leu Thr Arg Lys Asp Leu Cys Ala Ala Met Asn Arg
            340                 345                 350         
Pro Cys Glu Thr Leu Gly Leu Ser His Val Ala Gly Met Cys Gln Pro
        355                 360                 365             
His Arg Ser Cys Ser Ile Asn Glu Asp Thr Gly Leu Pro Leu Ala Phe
    370                 375                 380                 
Thr Val Ala His Glu Leu Gly His Ser Phe Gly Ile Gln His Asp Gly
385                 390                 395                 400 
Ser Gly Asn Asp Cys Glu Pro Val Gly Lys Arg Pro Phe Ile Met Ser
                405                 410                 415     
Pro Gln Leu Leu Tyr Asp Ala Ala Pro Leu Thr Trp Ser Arg Cys Ser
            420                 425                 430         
Arg Gln Tyr Ile Thr Arg Phe Leu Asp Arg Gly Trp Gly Leu Cys Leu
        435                 440                 445             
Asp Asp Pro Pro Ala Lys Asp Ile Ile Asp Phe Pro Ser Val Pro Pro
    450                 455                 460                 
Gly Val Leu Tyr Asp Val Ser His Gln Cys Arg Leu Gln Tyr Gly Ala
465                 470                 475                 480 
Tyr Ser Ala Phe Cys Glu Asp Met Asp Asn Val Cys His Thr Leu Trp
                485                 490                 495     
Cys Ser Val Gly Thr Thr Cys His Ser Lys Leu Asp Ala Ala Val Asp
            500                 505                 510         
Gly Thr Arg Cys Gly Glu Asn Lys Trp Cys Leu Ser Gly Glu Cys Val
        515                 520                 525             
Pro Val Gly Phe Arg Pro Glu Ala Val Asp Gly Gly Trp Ser Gly Trp
    530                 535                 540                 
Ser Ala Trp Ser Ile Cys Ser Arg Ser Cys Gly Met Gly Val Gln Ser
545                 550                 555                 560 
Ala Glu Arg Gln Cys Thr Gln Pro Thr Pro Lys Tyr Lys Gly Arg Tyr
                565                 570                 575     
Cys Val Gly Glu Arg Lys Arg Phe Arg Leu Cys Asn Leu Gln Ala Cys
            580                 585                 590         
Pro Ala Gly Arg Pro Ser Phe Arg His Val Gln Cys Ser His Phe Asp
        595                 600                 605             
Ala Met Leu Tyr Lys Gly Gln Leu His Thr Trp Val Pro Val Val Asn
    610                 615                 620                 
Asp Val Asn Pro Cys Glu Leu His Cys Arg Pro Ala Asn Glu Tyr Phe
625                 630                 635                 640 
Ala Lys Lys Leu Arg Asp Ala Val Val Asp Gly Thr Pro Cys Tyr Gln
                645                 650                 655     
Val Arg Ala Ser Arg Asp Leu Cys Ile Asn Gly Ile Cys Lys Asn Val
            660                 665                 670         
Gly Cys Asp Phe Glu Ile Asp Ser Gly Ala Met Glu Asp Arg Cys Gly
        675                 680                 685             
Val Cys His Gly Asn Gly Ser Thr Cys His Thr Val Ser Gly Thr Phe
    690                 695                 700                 
Glu Glu Ala Glu Gly Leu Gly Tyr Val Asp Val Gly Leu Ile Pro Ala
705                 710                 715                 720 
Gly Ala Arg Glu Ile Arg Ile Gln Glu Val Ala Glu Ala Ala Asn Phe
                725                 730                 735     
Leu Ala Leu Arg Ser Glu Asp Pro Glu Lys Tyr Phe Leu Asn Gly Gly
            740                 745                 750         
Trp Thr Ile Gln Trp Asn Gly Asp Tyr Gln Val Ala Gly Thr Thr Phe
        755                 760                 765             
Thr Tyr Ala Arg Arg Gly Asn Trp Glu Asn Leu Thr Ser Pro Gly Pro
    770                 775                 780                 
Thr Lys Glu Pro Val Trp Ile Gln Val Pro Ala Ser Arg Gly Pro Gly
785                 790                 795                 800 
Gly Gly Ser Arg Gly Gly Val Pro Arg Pro Ser Thr Leu His Gly Arg
                805                 810                 815     
Ser Arg Pro Gly Gly Val Ser Pro Gly Ser Val Thr Glu Pro Gly Ser
            820                 825                 830         
Glu Pro Gly Pro Pro Ala Ala Ala Ser Thr Ser Val Ser Pro Ser Leu
        835                 840                 845             
Lys Trp Pro Asn Leu Val Ala Ala Val His Arg Gly Gly Trp Gly Gln
    850                 855                 860                 
Ala Pro Leu Gly Leu Gly Gly Trp Arg Arg His Leu Val Leu Met Gly
865                 870                 875                 880 
Pro Arg Leu Pro Thr Gln Leu Leu Phe Gln Glu Ser Asn Pro Gly Val
                885                 890                 895     
His Tyr Glu Tyr Thr Ile His Arg Glu Ala Gly Gly His Asp Glu Val
            900                 905                 910         
Pro Pro Pro Val Phe Ser Trp His Tyr Gly Pro Trp Thr Lys Cys Thr
        915                 920                 925             
Val Thr Cys Gly Arg Gly Glu Lys Trp Gly Arg His Ser Pro Thr Cys
    930                 935                 940                 
Arg Gly Leu Val Ser Gly Gln Gly His Trp Leu Gln Leu Pro Ala His
945                 950                 955                 960 
Cys Trp Ala Thr Thr Gly Leu Glu Val Cys Phe Ser Glu Pro Gln Phe
                965                 970                 975     
Ser Ile Cys Glu Met Arg Leu Ala Ile Ala Leu Cys Pro Arg Pro Ala
            980                 985                 990         
Gly Arg Val His Gly
        995         


<210> 1095
<211> 592
<212> PRT
<213> Homo sapiens

<400> 1095
Met Glu Gly Lys Trp Leu Leu Cys Met Leu Leu Val Leu Gly Thr Ala
 1               5                  10                  15      
Ile Val Glu Ala His Asp Gly His Asp Asp Asp Val Ile Asp Ile Glu
            20                  25                  30          
Asp Asp Leu Asp Asp Val Ile Glu Glu Val Glu Asp Ser Lys Pro Asp
        35                  40                  45              
Thr Thr Ala Pro Pro Ser Ser Pro Lys Val Thr Tyr Lys Ala Pro Val
    50                  55                  60                  
Pro Thr Gly Glu Val Tyr Phe Ala Asp Ser Phe Asp Arg Gly Thr Leu
65                  70                  75                  80  
Ser Gly Trp Ile Leu Ser Lys Ala Lys Lys Asp Asp Thr Asp Asp Glu
                85                  90                  95      
Ile Ala Lys Tyr Asp Gly Lys Trp Glu Val Glu Glu Met Lys Glu Ser
            100                 105                 110         
Lys Leu Pro Gly Asp Lys Gly Leu Val Leu Met Ser Arg Ala Lys His
        115                 120                 125             
His Ala Ile Ser Ala Lys Leu Asn Lys Pro Phe Leu Phe Asp Thr Lys
    130                 135                 140                 
Pro Leu Ile Val Gln Tyr Glu Val Asn Phe Gln Asn Gly Ile Glu Cys
145                 150                 155                 160 
Gly Gly Ala Tyr Val Lys Leu Leu Ser Lys Thr Pro Glu Leu Asn Leu
                165                 170                 175     
Asp Gln Phe His Asp Lys Thr Pro Tyr Thr Ile Met Phe Gly Pro Asp
            180                 185                 190         
Lys Cys Gly Glu Asp Tyr Lys Leu His Phe Ile Phe Arg His Lys Asn
        195                 200                 205             
Pro Lys Thr Gly Ile Tyr Glu Glu Lys His Ala Lys Arg Pro Asp Ala
    210                 215                 220                 
Asp Leu Lys Thr Tyr Phe Thr Asp Lys Lys Thr His Leu Tyr Thr Leu
225                 230                 235                 240 
Ile Leu Asn Pro Asp Asn Ser Phe Glu Ile Leu Val Asp Gln Ser Val
                245                 250                 255     
Val Asn Ser Gly Asn Leu Leu Asn Asp Met Thr Pro Pro Val Asn Pro
            260                 265                 270         
Ser Arg Glu Ile Glu Asp Pro Glu Asp Arg Lys Pro Glu Asp Trp Asp
        275                 280                 285             
Glu Arg Pro Lys Ile Pro Asp Pro Glu Ala Val Lys Pro Asp Asp Trp
    290                 295                 300                 
Asp Glu Asp Ala Pro Ala Lys Ile Pro Asp Glu Glu Ala Thr Lys Pro
305                 310                 315                 320 
Glu Gly Trp Leu Asp Asp Glu Pro Glu Tyr Val Pro Asp Pro Asp Ala
                325                 330                 335     
Glu Lys Pro Glu Asp Trp Asp Glu Asp Met Asp Gly Glu Trp Glu Ala
            340                 345                 350         
Pro Gln Ile Ala Asn Pro Arg Cys Glu Ser Ala Pro Gly Cys Gly Val
        355                 360                 365             
Trp Gln Arg Pro Val Ile Asp Asn Pro Asn Tyr Lys Gly Lys Trp Lys
    370                 375                 380                 
Pro Pro Met Ile Asp Asn Pro Ser Tyr Gln Gly Ile Trp Lys Pro Arg
385                 390                 395                 400 
Lys Ile Pro Asn Pro Asp Phe Phe Glu Asp Leu Glu Pro Phe Arg Met
                405                 410                 415     
Thr Pro Phe Ser Ala Ile Gly Leu Glu Leu Trp Ser Met Thr Ser Asp
            420                 425                 430         
Ile Phe Phe Asp Asn Phe Ile Ile Cys Ala Asp Arg Arg Ile Val Asp
        435                 440                 445             
Asp Trp Ala Asn Asp Gly Trp Gly Leu Lys Lys Ala Ala Asp Gly Ala
    450                 455                 460                 
Ala Glu Pro Gly Val Val Gly Gln Met Ile Glu Ala Ala Glu Glu Arg
465                 470                 475                 480 
Pro Trp Leu Trp Val Val Tyr Ile Leu Thr Val Ala Leu Pro Val Phe
                485                 490                 495     
Leu Val Ile Leu Phe Cys Cys Ser Gly Lys Lys Gln Thr Ser Gly Met
            500                 505                 510         
Glu Tyr Lys Lys Thr Asp Ala Pro Gln Pro Asp Val Lys Glu Glu Glu
        515                 520                 525             
Glu Glu Lys Glu Glu Glu Lys Asp Lys Gly Asp Glu Glu Glu Glu Gly
    530                 535                 540                 
Glu Glu Lys Leu Glu Glu Lys Gln Lys Ser Asp Ala Glu Glu Asp Gly
545                 550                 555                 560 
Gly Thr Val Ser Gln Glu Glu Glu Asp Arg Lys Pro Lys Ala Glu Glu
                565                 570                 575     
Asp Glu Ile Leu Asn Arg Ser Pro Arg Asn Arg Lys Pro Arg Arg Glu
            580                 585                 590         


<210> 1096
<211> 418
<212> PRT
<213> Homo sapiens

<400> 1096
Met Leu Pro Glu Asp Lys Glu Ala Asp Ser Leu Arg Gly Asn Ile Ser
 1               5                  10                  15      
Val Lys Ala Val Lys Lys Glu Val Glu Lys Lys Leu Arg Cys Leu Leu
            20                  25                  30          
Ala Asp Leu Pro Leu Pro Pro Glu Leu Pro Gly Gly Asp Asp Leu Ser
        35                  40                  45              
Lys Ser Pro Glu Glu Lys Lys Thr Thr Thr Gln Leu His Ser Lys Arg
    50                  55                  60                  
Arg Pro Lys Ile Cys Gly Pro Arg Tyr Gly Glu Thr Lys Glu Lys Asp
65                  70                  75                  80  
Ile Asp Trp Gly Lys Leu Cys Val Asp Lys Phe Asp Ile Ile Gly Ile
                85                  90                  95      
Ile Gly Glu Gly Thr Tyr Gly Gln Val Tyr Lys Ala Arg Asp Lys Asp
            100                 105                 110         
Thr Gly Glu Met Val Ala Leu Lys Lys Val Arg Leu Asp Asn Glu Lys
        115                 120                 125             
Glu Gly Phe Pro Ile Thr Ala Ile Arg Glu Ile Lys Ile Leu Arg Gln
    130                 135                 140                 
Leu Thr His Gln Ser Ile Ile Asn Met Lys Glu Ile Val Thr Asp Lys
145                 150                 155                 160 
Glu Asp Ala Leu Asp Phe Lys Lys Asp Lys Gly Ala Phe Tyr Leu Val
                165                 170                 175     
Phe Glu Tyr Met Asp His Asp Leu Met Gly Leu Leu Glu Ser Gly Leu
            180                 185                 190         
Val His Phe Tyr Glu Asn His Ile Lys Ser Phe Met Arg Gln Leu Met
        195                 200                 205             
Glu Gly Leu Asp Tyr Cys His Lys Lys Asn Phe Leu His Arg Asp Ile
    210                 215                 220                 
Lys Cys Ser Asn Ile Leu Leu Asn Asn Arg Gly Gln Ile Lys Leu Ala
225                 230                 235                 240 
Asp Phe Gly Leu Ala Arg Leu Tyr Ser Ser Glu Glu Ser Arg Pro Tyr
                245                 250                 255     
Thr Asn Lys Val Ile Thr Leu Trp Tyr Arg Pro Pro Glu Leu Leu Leu
            260                 265                 270         
Gly Glu Glu Arg Tyr Thr Pro Ala Ile Asp Val Trp Ser Cys Gly Cys
        275                 280                 285             
Ile Leu Gly Glu Leu Phe Thr Lys Lys Pro Ile Phe Gln Ala Asn Gln
    290                 295                 300                 
Glu Leu Ala Gln Leu Glu Leu Ile Ser Arg Ile Cys Gly Ser Pro Cys
305                 310                 315                 320 
Pro Ala Val Trp Pro Asp Val Ile Lys Leu Pro Tyr Phe Asn Thr Met
                325                 330                 335     
Lys Pro Lys Lys Gln Tyr Arg Arg Lys Leu Arg Glu Glu Phe Val Phe
            340                 345                 350         
Ile Pro Ala Ala Ala Leu Asp Leu Phe Asp Tyr Met Leu Ala Leu Asp
        355                 360                 365             
Pro Ser Lys Arg Cys Thr Ala Glu Gln Ala Leu Gln Cys Glu Phe Leu
    370                 375                 380                 
Arg Asp Val Glu Pro Ser Lys Cys Leu His Gln Ile Ser Leu Tyr Gly
385                 390                 395                 400 
Lys Ile Val Met Ser Tyr Gly Val Lys Ser Glu Glu Asp Arg Ser Arg
                405                 410                 415     
Trp Ala
        


<210> 1097
<211> 374
<212> PRT
<213> Homo sapiens

<400> 1097
Asp Phe Phe Glu Asp Pro Ser Ser Glu Arg Lys Glu Lys Lys Glu Arg
 1               5                  10                  15      
Ile Pro Val Phe Cys Ile Asp Val Glu Arg Asn Asp Arg Arg Ala Val
            20                  25                  30          
Gly His Glu Pro Glu His Trp Ser Val Tyr Arg Arg Tyr Leu Glu Phe
        35                  40                  45              
Tyr Val Leu Glu Ser Lys Leu Thr Glu Phe His Gly Ala Phe Pro Asp
    50                  55                  60                  
Ala Gln Leu Pro Ser Lys Arg Ile Ile Gly Pro Lys Asn Tyr Glu Phe
65                  70                  75                  80  
Leu Lys Ser Lys Arg Glu Glu Phe Gln Glu Tyr Leu Gln Lys Leu Leu
                85                  90                  95      
Gln His Pro Glu Leu Ser Asn Ser Gln Leu Leu Ala Asp Phe Leu Ser
            100                 105                 110         
Pro Asn Gly Gly Glu Thr Gln Phe Leu Asp Lys Ile Leu Pro Asp Val
        115                 120                 125             
Asn Leu Gly Lys Ile Ile Lys Ser Val Pro Gly Lys Leu Met Lys Glu
    130                 135                 140                 
Lys Gly Gln His Leu Glu Pro Phe Ile Met Asn Phe Ile Asn Ser Cys
145                 150                 155                 160 
Glu Ser Pro Lys Pro Lys Pro Ser Arg Pro Glu Leu Thr Ile Leu Ser
                165                 170                 175     
Pro Thr Ser Glu Asn Asn Lys Lys Leu Phe Asn Asp Leu Phe Lys Asn
            180                 185                 190         
Asn Ala Asn Arg Ala Glu Asn Thr Glu Arg Lys Gln Asn Gln Asn Tyr
        195                 200                 205             
Phe Met Glu Val Met Thr Val Glu Gly Val Tyr Asp Tyr Leu Met Tyr
    210                 215                 220                 
Val Gly Arg Val Val Phe Gln Val Pro Asp Trp Leu His His Leu Leu
225                 230                 235                 240 
Met Gly Thr Arg Ile Leu Phe Lys Asn Thr Leu Glu Met Tyr Thr Asp
                245                 250                 255     
Tyr Tyr Leu Gln Cys Lys Leu Glu Gln Leu Phe Gln Glu His Arg Leu
            260                 265                 270         
Val Ser Leu Ile Thr Leu Leu Arg Asp Ala Ile Phe Cys Glu Asn Thr
        275                 280                 285             
Glu Pro Arg Ser Leu Gln Asp Lys Gln Lys Gly Ala Lys Gln Thr Phe
    290                 295                 300                 
Glu Glu Met Met Asn Tyr Ile Pro Asp Leu Leu Val Lys Cys Ile Gly
305                 310                 315                 320 
Glu Glu Thr Lys Tyr Glu Ser Ile Arg Leu Leu Phe Asp Gly Leu Gln
                325                 330                 335     
Gln Pro Val Leu Asn Lys Gln Leu Thr Tyr Val Leu Leu Asp Ile Val
            340                 345                 350         
Ile Gln Glu Leu Phe Pro Glu Leu Asn Lys Val Gln Lys Glu Val Thr
        355                 360                 365             
Ser Val Thr Ser Trp Met
    370                 


<210> 1098
<211> 1443
<212> PRT
<213> Homo sapiens

<400> 1098
Tyr Gly Lys Leu Thr Asp Ala Tyr Gly Cys Leu Gly Glu Leu Arg Leu
 1               5                  10                  15      
Lys Ser Gly Gly Thr Ser Leu Ser Phe Leu Val Leu Val Thr Gly Cys
            20                  25                  30          
Thr Ser Val Gly Arg Ile Pro Asp Ala Glu Ile Tyr Lys Ile Thr Ala
        35                  40                  45              
Thr Asp Phe Tyr Pro Leu Gln Glu Glu Ala Lys Glu Glu Glu Arg Leu
    50                  55                  60                  
Ile Ala Leu Lys Lys Ile Leu Ser Ser Gly Val Phe Tyr Phe Ser Trp
65                  70                  75                  80  
Pro Asn Asp Gly Ser Arg Phe Asp Leu Thr Val Arg Thr Gln Lys Gln
                85                  90                  95      
Gly Asp Asp Ser Ser Glu Trp Gly Asn Ser Phe Phe Trp Asn Gln Leu
            100                 105                 110         
Leu His Val Pro Leu Arg Gln His Gln Val Ser Cys Cys Asp Trp Leu
        115                 120                 125             
Leu Lys Ile Ile Cys Gly Val Val Thr Ile Arg Thr Val Tyr Ala Ser
    130                 135                 140                 
His Lys Gln Ala Lys Ala Cys Leu Val Ser Arg Val Ser Cys Glu Arg
145                 150                 155                 160 
Thr Gly Thr Arg Phe His Thr Arg Gly Val Asn Asp Asp Gly His Val
                165                 170                 175     
Ser Asn Phe Val Glu Thr Glu Gln Met Ile Tyr Met Asp Asp Gly Val
            180                 185                 190         
Ser Ser Phe Val Gln Ile Arg Gly Ser Val Pro Leu Phe Trp Glu Gln
        195                 200                 205             
Pro Gly Leu Gln Val Gly Ser His His Leu Arg Leu His Arg Gly Leu
    210                 215                 220                 
Glu Ala Asn Ala Pro Ala Phe Asp Arg His Met Val Leu Leu Lys Glu
225                 230                 235                 240 
Gln Tyr Gly Gln Gln Val Val Val Asn Leu Leu Gly Ser Arg Gly Gly
                245                 250                 255     
Glu Glu Val Leu Asn Arg Ala Phe Lys Lys Leu Leu Trp Ala Ser Cys
            260                 265                 270         
His Ala Gly Asp Thr Pro Met Ile Asn Phe Asp Phe His Gln Phe Ala
        275                 280                 285             
Lys Gly Gly Lys Leu Glu Lys Leu Glu Thr Leu Leu Arg Pro Gln Leu
    290                 295                 300                 
Lys Leu His Trp Glu Asp Phe Asp Val Phe Thr Lys Gly Glu Asn Val
305                 310                 315                 320 
Ser Pro Arg Phe Gln Lys Gly Thr Leu Arg Met Asn Cys Leu Asp Cys
                325                 330                 335     
Leu Asp Arg Thr Asn Thr Val Gln Ser Phe Ile Ala Leu Glu Val Leu
            340                 345                 350         
His Leu Gln Leu Lys Thr Leu Gly Leu Ser Ser Lys Pro Ile Val Asp
        355                 360                 365             
Arg Phe Val Glu Ser Phe Lys Ala Met Trp Ser Leu Asn Gly His Ser
    370                 375                 380                 
Leu Ser Lys Val Phe Thr Gly Ser Arg Ala Leu Glu Gly Lys Ala Lys
385                 390                 395                 400 
Val Gly Lys Leu Lys Asp Gly Ala Arg Ser Met Ser Arg Thr Ile Gln
                405                 410                 415     
Ser Asn Phe Phe Asp Gly Val Lys Gln Glu Ala Ile Lys Leu Leu Leu
            420                 425                 430         
Val Gly Asp Val Tyr Gly Glu Glu Val Ala Asp Lys Gly Gly Met Leu
        435                 440                 445             
Leu Asp Ser Thr Ala Leu Leu Val Thr Pro Arg Ile Leu Lys Ala Met
    450                 455                 460                 
Thr Glu Arg Gln Ser Glu Phe Thr Asn Phe Lys Arg Ile Arg Ile Ala
465                 470                 475                 480 
Met Gly Thr Trp Asn Val Asn Gly Gly Lys Gln Phe Arg Ser Asn Val
                485                 490                 495     
Leu Arg Thr Ala Glu Leu Thr Asp Trp Leu Leu Asp Ser Pro Gln Leu
            500                 505                 510         
Ser Gly Ala Thr Asp Ser Gln Asp Asp Ser Ser Pro Ala Asp Ile Phe
        515                 520                 525             
Ala Val Gly Phe Glu Glu Met Val Glu Leu Ser Ala Gly Asn Ile Val
    530                 535                 540                 
Asn Ala Ser Thr Thr Asn Lys Lys Met Trp Gly Glu Gln Leu Gln Lys
545                 550                 555                 560 
Ala Ile Ser Arg Ser His Arg Tyr Ile Leu Leu Thr Ser Ala Gln Leu
                565                 570                 575     
Val Gly Val Cys Leu Tyr Ile Phe Val Arg Pro Tyr His Val Pro Phe
            580                 585                 590         
Ile Arg Asp Val Ala Ile Asp Thr Val Lys Thr Gly Met Gly Gly Lys
        595                 600                 605             
Ala Gly Asn Lys Gly Ala Val Gly Ile Arg Phe Gln Phe His Ser Thr
    610                 615                 620                 
Ser Phe Cys Phe Ile Cys Ser His Leu Thr Ala Gly Gln Ser Gln Val
625                 630                 635                 640 
Lys Glu Arg Asn Glu Asp Tyr Lys Glu Ile Thr Gln Lys Leu Cys Phe
                645                 650                 655     
Pro Met Gly Arg Asn Val Phe Ser His Asp Tyr Val Phe Trp Cys Gly
            660                 665                 670         
Asp Phe Asn Tyr Arg Ile Asp Leu Thr Tyr Glu Glu Val Phe Tyr Phe
        675                 680                 685             
Val Lys Arg Gln Asp Trp Lys Lys Leu Leu Glu Phe Asp Gln Leu Gln
    690                 695                 700                 
Leu Gln Lys Ser Ser Gly Lys Ile Phe Lys Asp Phe His Glu Gly Ala
705                 710                 715                 720 
Ile Asn Phe Gly Pro Thr Tyr Lys Tyr Asp Val Gly Ser Ala Ala Tyr
                725                 730                 735     
Asp Thr Ser Asp Lys Cys Arg Thr Pro Ala Trp Thr Asp Arg Val Leu
            740                 745                 750         
Trp Trp Arg Lys Lys His Pro Phe Asp Lys Thr Ala Gly Glu Leu Asn
        755                 760                 765             
Leu Leu Asp Ser Asp Leu Asp Val Asp Thr Lys Val Arg His Thr Trp
    770                 775                 780                 
Ser Pro Gly Ala Leu Gln Tyr Tyr Gly Arg Ala Glu Leu Gln Ala Ser
785                 790                 795                 800 
Asp His Arg Pro Val Leu Ala Ile Val Glu Val Glu Val Gln Glu Val
                805                 810                 815     
Asp Val Gly Ala Arg Glu Arg Val Phe Gln Glu Val Ser Ser Phe Gln
            820                 825                 830         
Gly Pro Leu Asp Ala Thr Val Val Val Asn Leu Gln Ser Pro Thr Leu
        835                 840                 845             
Glu Glu Lys Asn Glu Phe Pro Glu Asp Leu Arg Thr Glu Leu Met Gln
    850                 855                 860                 
Thr Leu Gly Ser Tyr Gly Thr Ile Val Leu Val Arg Ile Asn Gln Gly
865                 870                 875                 880 
Gln Met Leu Val Thr Phe Ala Asp Ser His Ser Ala Leu Ser Val Leu
                885                 890                 895     
Asp Val Asp Gly Met Lys Val Lys Gly Arg Ala Val Lys Ile Arg Pro
            900                 905                 910         
Lys Thr Lys Asp Trp Leu Lys Gly Leu Arg Glu Glu Ile Ile Arg Lys
        915                 920                 925             
Arg Asp Ser Met Ala Pro Val Ser Pro Thr Ala Asn Ser Cys Leu Leu
    930                 935                 940                 
Glu Glu Asn Phe Asp Phe Thr Ser Leu Asp Tyr Glu Ser Glu Gly Asp
945                 950                 955                 960 
Ile Leu Glu Asp Asp Glu Asp Tyr Leu Val Asp Glu Phe Asn Gln Pro
                965                 970                 975     
Gly Val Ser Asp Ser Glu Leu Gly Gly Asp Asp Leu Ser Asp Val Pro
            980                 985                 990         
Gly Pro Thr Ala Leu Ala Pro Pro Ser Lys Ser Pro Ala Leu Thr Lys
        995                 1000                1005            
Lys Lys Gln His Pro Thr Tyr Lys Asp Asp Ala Asp Leu Val Glu Leu
    1010                1015                1020                
Lys Arg Glu Leu Glu Ala Val Gly Glu Phe Arg His Arg Ser Pro Ser
1025                1030                1035                1040
Arg Ser Leu Ser Val Pro Asn Arg Pro Arg Pro Pro Gln Pro Pro Gln
                1045                1050                1055    
Arg Pro Pro Pro Pro Thr Gly Leu Met Val Lys Lys Ser Ala Ser Asp
            1060                1065                1070        
Ala Ser Ile Ser Ser Gly Thr His Gly Gln Tyr Ser Ile Leu Gln Thr
        1075                1080                1085            
Ala Arg Leu Leu Pro Gly Ala Pro Gln Gln Pro Pro Lys Ala Arg Thr
    1090                1095                1100                
Gly Ile Ser Lys Pro Tyr Asn Val Lys Gln Ile Lys Thr Thr Asn Ala
1105                1110                1115                1120
Gln Glu Ala Glu Ala Ala Ile Arg Cys Leu Leu Glu Ala Arg Gly Gly
                1125                1130                1135    
Ala Ser Glu Glu Ala Leu Ser Ala Val Ala Pro Arg Asp Leu Glu Ala
            1140                1145                1150        
Ser Ser Glu Pro Glu Pro Thr Pro Gly Ala Ala Lys Pro Glu Thr Pro
        1155                1160                1165            
Gln Ala Pro Pro Leu Leu Pro Arg Arg Pro Pro Pro Arg Val Pro Ala
    1170                1175                1180                
Ile Lys Lys Pro Thr Leu Arg Arg Thr Gly Lys Pro Leu Ser Pro Glu
1185                1190                1195                1200
Glu Gln Phe Glu Gln Gln Thr Val His Phe Thr Ile Gly Pro Pro Glu
                1205                1210                1215    
Thr Ser Val Glu Ala Pro Pro Val Val Thr Ala Pro Arg Val Pro Pro
            1220                1225                1230        
Val Pro Lys Pro Arg Thr Phe Gln Pro Gly Lys Ala Ala Glu Arg Pro
        1235                1240                1245            
Ser His Arg Lys Pro Ala Ser Asp Glu Ala Pro Pro Gly Ala Gly Ala
    1250                1255                1260                
Ser Val Pro Pro Pro Leu Glu Ala Pro Pro Leu Val Pro Lys Val Pro
1265                1270                1275                1280
Pro Arg Arg Lys Lys Ser Ala Pro Ala Ala Phe His Leu Gln Val Leu
                1285                1290                1295    
Gln Ser Asn Ser Gln Leu Leu Gln Gly Leu Thr Tyr Asn Ser Ser Asp
            1300                1305                1310        
Ser Pro Ser Gly His Pro Pro Ala Ala Gly Thr Val Phe Pro Gln Gly
        1315                1320                1325            
Asp Phe Leu Ser Thr Ser Ser Ala Thr Ser Pro Asp Ser Asp Gly Thr
    1330                1335                1340                
Lys Ala Met Lys Pro Glu Ala Ala Pro Leu Leu Gly Asp Tyr Gln Asp
1345                1350                1355                1360
Pro Phe Trp Asn Leu Leu His His Pro Lys Leu Leu Asn Asn Thr Trp
                1365                1370                1375    
Leu Ser Lys Ser Ser Asp Pro Leu Asp Ser Gly Thr Arg Ser Pro Lys
            1380                1385                1390        
Arg Asp Pro Ile Asp Pro Val Ser Ala Gly Ala Ser Ala Ala Lys Ala
        1395                1400                1405            
Glu Leu Pro Pro Asp His Glu His Lys Thr Leu Gly His Trp Val Thr
    1410                1415                1420                
Ile Ser Asp Gln Glu Lys Arg Thr Ala Leu Gln Val Phe Asp Pro Leu
1425                1430                1435                1440
Ala Lys Thr
            


<210> 1099
<211> 1818
<212> PRT
<213> Homo sapiens

<400> 1099
Met Asp Arg Val Gly Gly Gly Lys Gly Pro Gly Gly Ser Tyr Tyr Arg
 1               5                  10                  15      
Val Ser Ser Ser Ala Ala Arg Ser Arg Lys Leu Cys Pro Gly Arg Val
            20                  25                  30          
Asn Arg Gly Leu Ser Ala Gln Ser Thr Ala Ala Thr Ala Thr Met Gly
        35                  40                  45              
Gly Lys Asn Lys Gln Arg Thr Lys Gly Asn Leu Arg Pro Ser Asn Ser
    50                  55                  60                  
Gly Arg Ala Ala Glu Leu Leu Ala Lys Glu Gln Gly Thr Val Pro Gly
65                  70                  75                  80  
Phe Ile Gly Phe Gly Thr Ser Gln Ser Asp Leu Gly Tyr Val Pro Ala
                85                  90                  95      
Ile Gln Gly Ala Glu Glu Ile Asp Ser Leu Val Asp Ser Asp Phe Arg
            100                 105                 110         
Met Val Leu Arg Lys Leu Ser Lys Lys Asp Val Thr Thr Lys Leu Lys
        115                 120                 125             
Ala Met Gln Glu Phe Gly Thr Met Cys Thr Glu Arg Asp Thr Glu Thr
    130                 135                 140                 
Val Lys Gly Val Leu Pro Tyr Trp Pro Arg Ile Phe Cys Lys Ile Ser
145                 150                 155                 160 
Leu Asp His Asp Arg Arg Val Arg Glu Ala Thr Gln Gln Ala Phe Glu
                165                 170                 175     
Lys Leu Ile Leu Lys Val Lys Lys Gln Leu Ala Pro Tyr Leu Lys Ser
            180                 185                 190         
Leu Met Gly Tyr Trp Leu Met Ala Gln Cys Asp Thr Tyr Thr Pro Ala
        195                 200                 205             
Ala Phe Ala Ala Lys Asp Ala Phe Glu Ala Ala Phe Pro Pro Ser Lys
    210                 215                 220                 
Gln Pro Glu Ala Ile Ala Phe Cys Lys Asp Glu Ile Thr Ser Val Ser
225                 230                 235                 240 
Ser Gly Ile Ile Val Leu Gln Asp His Leu Ile Lys Glu Thr Pro Asp
                245                 250                 255     
Thr Leu Ser Asp Pro Gln Thr Val Pro Glu Glu Glu Arg Glu Ala Lys
            260                 265                 270         
Phe Tyr Arg Val Val Thr Cys Ser Leu Leu Ala Leu Lys Arg Leu Leu
        275                 280                 285             
Cys Leu Leu Pro Asp Asn Glu Leu Asp Ser Leu Glu Glu Lys Phe Lys
    290                 295                 300                 
Ser Leu Leu Ser Gln Asn Lys Phe Trp Lys Tyr Gly Lys His Ser Val
305                 310                 315                 320 
Pro Gln Ile Arg Ser Ala Tyr Phe Glu Leu Val Ser Ala Leu Cys Gln
                325                 330                 335     
Arg Ile Pro Gln Leu Met Lys Glu Glu Ala Ser Lys Val Ser Pro Ser
            340                 345                 350         
Val Leu Leu Ser Ile Asp Asp Ser Asp Pro Ile Val Cys Pro Ala Leu
        355                 360                 365             
Trp Glu Ala Val Leu Tyr Thr Leu Thr Thr Ile Glu Asp Cys Trp Leu
    370                 375                 380                 
His Val Asn Ala Lys Lys Ser Val Phe Pro Lys Leu Ser Thr Val Ile
385                 390                 395                 400 
Arg Glu Gly Gly Arg Gly Leu Ala Thr Val Ile Tyr Pro Tyr Leu Leu
                405                 410                 415     
Pro Phe Ile Ser Lys Leu Pro Gln Ser Ile Thr Asn Pro Lys Leu Asp
            420                 425                 430         
Phe Phe Lys Asn Phe Leu Thr Ser Leu Val Ala Gly Leu Ser Thr Glu
        435                 440                 445             
Arg Thr Lys Thr Ser Ser Leu Glu Ser Ser Ala Val Ile Ser Ala Phe
    450                 455                 460                 
Phe Glu Cys Leu Arg Phe Ile Met Gln Gln Asn Leu Gly Glu Glu Glu
465                 470                 475                 480 
Ile Glu Gln Met Leu Val Asn Asp Gln Leu Ile Pro Phe Ile Asp Ala
                485                 490                 495     
Val Leu Lys Asp Pro Gly Leu Gln His Gly Gln Leu Phe Asn His Leu
            500                 505                 510         
Ala Glu Thr Leu Ser Ser Trp Glu Ala Lys Ala Asp Thr Glu Lys Asp
        515                 520                 525             
Glu Lys Thr Ala His Asn Leu Glu Asn Val Leu Ile His Phe Trp Glu
    530                 535                 540                 
Arg Leu Ser Glu Ile Cys Val Ala Lys Ile Ser Glu Pro Glu Ala Asp
545                 550                 555                 560 
Val Glu Ser Val Leu Gly Val Ser Asn Leu Leu Gln Val Leu Gln Lys
                565                 570                 575     
Pro Lys Ser Ser Leu Lys Ser Ser Lys Lys Lys Asn Gly Lys Val Arg
            580                 585                 590         
Phe Ala Asp Glu Ile Leu Glu Ser Asn Lys Glu Asn Glu Lys Cys Val
        595                 600                 605             
Ser Ser Glu Gly Glu Lys Ile Glu Gly Trp Glu Leu Thr Thr Glu Pro
    610                 615                 620                 
Ser Leu Thr His Asn Ser Ser Gly Leu Leu Ser Pro Leu Arg Lys Lys
625                 630                 635                 640 
Pro Leu Glu Asp Leu Val Cys Lys Leu Ala Asp Ile Ser Ile Asn Tyr
                645                 650                 655     
Val Asn Glu Arg Lys Ser Glu Gln His Leu Arg Phe Leu Ser Thr Leu
            660                 665                 670         
Leu Asp Ser Phe Ser Ser Ser Arg Val Phe Lys Met Leu Leu Gly Asp
        675                 680                 685             
Glu Lys Gln Ser Ile Val Gln Ala Lys Pro Leu Glu Ile Ala Lys Leu
    690                 695                 700                 
Val Gln Lys Asn Pro Ala Val Gln Phe Leu Tyr Gln Lys Leu Ile Gly
705                 710                 715                 720 
Trp Leu Asn Glu Asp Gln Arg Lys Asp Phe Gly Phe Leu Val Asp Ile
                725                 730                 735     
Leu Tyr Ser Ala Leu Arg Cys Cys Asp Asn Asp Met Glu Arg Lys Lys
            740                 745                 750         
Val Leu Asp Asp Leu Thr Lys Val Asp Leu Lys Trp Asn Ser Leu Leu
        755                 760                 765             
Lys Ile Ile Glu Lys Ala Cys Pro Ser Ser Asp Lys His Ala Leu Val
    770                 775                 780                 
Thr Pro Trp Leu Lys Gly Asp Ile Leu Gly Glu Lys Leu Val Asn Leu
785                 790                 795                 800 
Ala Asp Cys Leu Cys Asn Glu Asp Leu Glu Ser Arg Val Ser Ser Glu
                805                 810                 815     
Ser His Phe Ser Glu Arg Trp Thr Leu Leu Ser Leu Val Leu Ser Gln
            820                 825                 830         
His Val Lys Asn Asp Tyr Leu Ile Gly Asp Val Tyr Val Glu Arg Ile
        835                 840                 845             
Ile Val Arg Leu His Glu Thr Leu Phe Lys Thr Lys Lys Leu Ser Glu
    850                 855                 860                 
Ala Glu Ser Ser Asp Ser Ser Val Ser Phe Ile Cys Asp Val Ala Tyr
865                 870                 875                 880 
Asn Tyr Phe Ser Ser Ala Lys Gly Cys Leu Leu Met Pro Ser Ser Glu
                885                 890                 895     
Asp Leu Leu Leu Thr Leu Phe Gln Leu Cys Ala Gln Ser Lys Glu Lys
            900                 905                 910         
Thr His Leu Pro Asp Phe Leu Ile Cys Lys Leu Lys Asn Thr Trp Leu
        915                 920                 925             
Ser Gly Val Asn Leu Leu Val His Gln Thr Asp Ser Ser Tyr Lys Glu
    930                 935                 940                 
Ser Thr Phe Leu His Leu Ser Ala Leu Trp Leu Lys Asn Gln Val Gln
945                 950                 955                 960 
Ala Ser Ser Leu Asp Ile Asn Ser Leu Gln Val Leu Leu Ser Ala Val
                965                 970                 975     
Asp Asp Leu Leu Asn Thr Leu Leu Glu Ser Glu Asp Ser Tyr Leu Met
            980                 985                 990         
Gly Val Tyr Ile Gly Ser Val Met Pro Asn Asp Ser Glu Trp Glu Lys
        995                 1000                1005            
Met Arg Gln Ser Leu Pro Met Gln Trp Leu His Arg Pro Leu Leu Glu
    1010                1015                1020                
Gly Arg Leu Ser Leu Asn Tyr Glu Cys Phe Lys Thr Asp Phe Lys Glu
1025                1030                1035                1040
Gln Asp Ile Lys Thr Leu Pro Ser His Leu Cys Thr Ser Ala Leu Leu
                1045                1050                1055    
Ser Lys Met Val Leu Ile Ala Leu Arg Lys Glu Thr Val Leu Glu Asn
            1060                1065                1070        
Asn Glu Leu Glu Lys Ile Ile Ala Glu Leu Leu Tyr Ser Leu Gln Trp
        1075                1080                1085            
Cys Glu Glu Leu Asp Asn Pro Pro Ile Phe Leu Ile Gly Phe Cys Glu
    1090                1095                1100                
Ile Leu Gln Lys Met Asn Ile Thr Tyr Asp Asn Leu Arg Val Leu Gly
1105                1110                1115                1120
Asn Thr Ser Gly Leu Leu Gln Leu Leu Phe Asn Arg Ser Arg Glu His
                1125                1130                1135    
Gly Thr Leu Trp Ser Leu Ile Ile Ala Lys Leu Ile Leu Ser Arg Ser
            1140                1145                1150        
Ile Ser Ser Asp Glu Val Lys Pro His Tyr Lys Arg Lys Glu Ser Phe
        1155                1160                1165            
Phe Pro Leu Thr Glu Gly Asn Leu His Thr Ile Gln Ser Leu Cys Pro
    1170                1175                1180                
Phe Leu Ser Lys Glu Glu Lys Lys Glu Phe Ser Ala Gln Cys Ile Pro
1185                1190                1195                1200
Ala Leu Leu Gly Trp Thr Lys Lys Asp Leu Cys Ser Thr Asn Gly Gly
                1205                1210                1215    
Phe Gly His Leu Ala Ile Phe Asn Ser Cys Leu Gln Thr Lys Ser Ile
            1220                1225                1230        
Asp Asp Gly Glu Leu Leu His Gly Ile Leu Lys Ile Ile Ile Ser Trp
        1235                1240                1245            
Lys Lys Glu His Glu Asp Ile Phe Leu Phe Ser Cys Asn Leu Ser Glu
    1250                1255                1260                
Ala Ser Pro Glu Val Leu Gly Val Asn Ile Glu Ile Ile Arg Phe Leu
1265                1270                1275                1280
Ser Leu Phe Leu Lys Tyr Cys Ser Ser Pro Leu Ala Glu Ser Glu Trp
                1285                1290                1295    
Asp Phe Ile Met Cys Ser Met Leu Ala Trp Leu Glu Thr Thr Ser Glu
            1300                1305                1310        
Asn Gln Ala Leu Tyr Ser Ile Pro Leu Val Gln Leu Phe Ala Cys Val
        1315                1320                1325            
Ser Cys Asp Leu Ala Cys Asp Leu Ser Ala Phe Phe Asp Ser Thr Thr
    1330                1335                1340                
Leu Asp Thr Ile Gly Asn Leu Pro Val Asn Leu Ile Ser Glu Trp Lys
1345                1350                1355                1360
Glu Phe Phe Ser Gln Gly Ile His Ser Leu Leu Leu Pro Ile Leu Val
                1365                1370                1375    
Thr Val Thr Gly Glu Asn Lys Asp Val Ser Glu Thr Ser Phe Gln Asn
            1380                1385                1390        
Ala Met Leu Lys Pro Met Cys Glu Thr Leu Thr Tyr Ile Ser Lys Glu
        1395                1400                1405            
Gln Leu Leu Ser His Lys Leu Pro Ala Arg Leu Val Ala Asp Gln Lys
    1410                1415                1420                
Thr Asn Leu Pro Glu Tyr Leu Gln Thr Leu Leu Asn Thr Leu Ala Pro
1425                1430                1435                1440
Leu Leu Leu Phe Arg Ala Arg Pro Val Gln Ile Ala Val Tyr His Met
                1445                1450                1455    
Leu Tyr Lys Leu Met Pro Glu Leu Pro Gln Tyr Asp Gln Asp Asn Leu
            1460                1465                1470        
Lys Ser Tyr Gly Asp Glu Glu Glu Glu Pro Ala Leu Ser Pro Pro Ala
        1475                1480                1485            
Ala Leu Met Ser Leu Leu Ser Ile Gln Glu Asp Leu Leu Glu Asn Val
    1490                1495                1500                
Leu Gly Cys Ile Pro Val Gly Gln Ile Val Thr Ile Lys Pro Leu Ser
1505                1510                1515                1520
Glu Asp Phe Cys Tyr Val Leu Gly Tyr Leu Leu Thr Trp Lys Leu Ile
                1525                1530                1535    
Leu Thr Phe Phe Lys Ala Ala Ser Ser Gln Leu Arg Ala Leu Tyr Ser
            1540                1545                1550        
Met Tyr Leu Arg Lys Thr Lys Ser Leu Asn Lys Leu Leu Tyr His Leu
        1555                1560                1565            
Phe Arg Leu Met Pro Glu Asn Pro Thr Tyr Ala Glu Thr Ala Val Glu
    1570                1575                1580                
Val Pro Asn Lys Asp Pro Lys Thr Phe Phe Thr Glu Glu Leu Gln Leu
1585                1590                1595                1600
Ser Ile Arg Glu Thr Thr Met Leu Pro Tyr His Ile Pro His Leu Ala
                1605                1610                1615    
Cys Ser Val Tyr His Met Thr Leu Lys Asp Leu Pro Ala Met Val Arg
            1620                1625                1630        
Leu Trp Trp Asn Ser Ser Glu Lys Arg Val Phe Asn Ile Val Asp Arg
        1635                1640                1645            
Phe Thr Ser Lys Tyr Val Ser Ser Val Leu Ser Phe Gln Glu Ile Ser
    1650                1655                1660                
Ser Val Gln Thr Ser Thr Gln Leu Phe Asn Gly Met Thr Val Lys Ala
1665                1670                1675                1680
Arg Ala Thr Thr Arg Glu Val Met Ala Thr Tyr Thr Ile Glu Asp Ile
                1685                1690                1695    
Val Ile Glu Leu Ile Ile Gln Leu Pro Ser Asn Tyr Pro Leu Gly Ser
            1700                1705                1710        
Ile Ile Val Glu Ser Gly Lys Arg Val Gly Val Ala Val Gln Gln Trp
        1715                1720                1725            
Arg Asn Trp Met Leu Gln Leu Ser Thr Tyr Leu Thr His Gln Asn Gly
    1730                1735                1740                
Ser Ile Met Glu Gly Leu Ala Leu Trp Lys Asn Asn Val Asp Lys Arg
1745                1750                1755                1760
Phe Glu Gly Val Glu Asp Cys Met Ile Cys Phe Ser Val Ile His Gly
                1765                1770                1775    
Phe Asn Tyr Ser Leu Pro Lys Lys Ala Cys Arg Thr Cys Lys Lys Lys
            1780                1785                1790        
Phe His Ser Ala Cys Leu Tyr Lys Trp Phe Thr Ser Ser Asn Lys Ser
        1795                1800                1805            
Thr Cys Pro Leu Cys Arg Glu Thr Phe Phe
    1810                1815            


<210> 1100
<211> 137
<212> PRT
<213> Homo sapiens

<400> 1100
Met Gly Ala His Leu Val Arg Arg Tyr Leu Gly Asp Ala Ser Val Glu
 1               5                  10                  15      
Pro Asp Pro Leu Gln Met Pro Thr Phe Pro Pro Asp Tyr Gly Phe Pro
            20                  25                  30          
Glu Arg Lys Glu Arg Glu Met Val Ala Thr Gln Gln Glu Met Met Asp
        35                  40                  45              
Ala Gln Leu Arg Leu Gln Leu Arg Asp Tyr Cys Ala His His Leu Ile
    50                  55                  60                  
Arg Leu Leu Lys Cys Lys Arg Asp Ser Phe Pro Asn Phe Leu Ala Cys
65                  70                  75                  80  
Lys Gln Glu Arg His Asp Trp Asp Tyr Cys Glu His Arg Asp Tyr Val
                85                  90                  95      
Met Arg Met Lys Glu Phe Glu Arg Glu Arg Arg Leu Leu Gln Arg Lys
            100                 105                 110         
Lys Arg Arg Glu Lys Lys Ala Ala Glu Leu Ala Lys Gly Gln Gly Pro
        115                 120                 125             
Gly Glu Val Asp Pro Lys Val Ala Leu
    130                 135         


<210> 1101
<211> 800
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 346
<223> Xaa = Any Amino Acid

<400> 1101
Met Ser Ser Leu Gly Ala Ser Phe Val Gln Ile Lys Phe Asp Asp Leu
 1               5                  10                  15      
Gln Phe Phe Glu Asn Cys Gly Gly Gly Ser Phe Gly Ser Val Tyr Arg
            20                  25                  30          
Ala Lys Trp Ile Ser Gln Asp Lys Glu Val Ala Val Lys Lys Leu Leu
        35                  40                  45              
Lys Ile Glu Lys Glu Ala Glu Ile Leu Ser Val Leu Ser His Arg Asn
    50                  55                  60                  
Ile Ile Gln Phe Tyr Gly Val Ile Leu Glu Pro Pro Asn Tyr Gly Ile
65                  70                  75                  80  
Val Thr Glu Tyr Ala Ser Leu Gly Ser Leu Tyr Asp Tyr Ile Asn Ser
                85                  90                  95      
Asn Arg Ser Glu Glu Met Asp Met Asp His Ile Met Thr Trp Ala Thr
            100                 105                 110         
Asp Val Ala Lys Gly Met His Tyr Leu His Met Glu Ala Pro Val Lys
        115                 120                 125             
Val Ile His Arg Asp Leu Lys Ser Arg Asn Val Val Ile Ala Ala Asp
    130                 135                 140                 
Gly Val Leu Lys Ile Cys Asp Phe Gly Ala Ser Arg Phe His Asn His
145                 150                 155                 160 
Thr Thr His Met Ser Leu Val Gly Thr Phe Pro Trp Met Ala Pro Glu
                165                 170                 175     
Val Ile Gln Ser Leu Pro Val Ser Glu Thr Cys Asp Thr Tyr Ser Tyr
            180                 185                 190         
Gly Val Val Leu Trp Glu Met Leu Thr Arg Glu Val Pro Phe Lys Gly
        195                 200                 205             
Leu Glu Gly Leu Gln Val Ala Trp Leu Val Val Glu Lys Asn Glu Arg
    210                 215                 220                 
Leu Thr Ile Pro Ser Ser Cys Pro Arg Ser Phe Ala Glu Leu Leu His
225                 230                 235                 240 
Gln Cys Trp Glu Ala Asp Ala Lys Lys Arg Pro Ser Phe Lys Gln Ile
                245                 250                 255     
Ile Ser Ile Leu Glu Ser Met Ser Asn Asp Thr Ser Leu Pro Asp Lys
            260                 265                 270         
Cys Asn Ser Phe Leu His Asn Lys Ala Glu Trp Arg Cys Glu Ile Glu
        275                 280                 285             
Ala Thr Leu Glu Arg Leu Lys Lys Leu Glu Arg Asp Leu Ser Phe Lys
    290                 295                 300                 
Glu Gln Glu Leu Lys Glu Arg Glu Arg Arg Leu Lys Met Trp Glu Gln
305                 310                 315                 320 
Lys Leu Thr Glu Gln Ser Asn Thr Pro Leu Leu Pro Ser Phe Glu Ile
                325                 330                 335     
Gly Ala Trp Thr Glu Asp Asp Val Tyr Xaa Trp Val Gln Gln Leu Val
            340                 345                 350         
Arg Lys Gly Asp Ser Ser Ala Glu Met Ser Val Tyr Ala Ser Leu Phe
        355                 360                 365             
Lys Glu Asn Asn Ile Thr Gly Lys Arg Leu Leu Leu Leu Glu Glu Glu
    370                 375                 380                 
Asp Leu Lys Asp Met Gly Ile Val Ser Lys Gly His Ile Ile His Phe
385                 390                 395                 400 
Lys Ser Ala Ile Glu Lys Leu Thr His Asp Tyr Ile Asn Leu Phe His
                405                 410                 415     
Phe Pro Pro Leu Ile Lys Asp Ser Gly Gly Glu Pro Glu Glu Asn Glu
            420                 425                 430         
Glu Lys Ile Val Asn Leu Glu Leu Val Phe Gly Phe His Leu Lys Pro
        435                 440                 445             
Gly Thr Gly Pro Gln Asp Cys Lys Trp Lys Met Tyr Met Glu Met Asp
    450                 455                 460                 
Gly Asp Glu Ile Ala Ile Thr Tyr Ile Lys Asp Val Thr Phe Asn Thr
465                 470                 475                 480 
Asn Leu Pro Asp Ala Glu Ile Leu Lys Met Thr Lys Pro Pro Phe Val
                485                 490                 495     
Met Glu Lys Trp Ile Val Gly Ile Ala Lys Ser Gln Thr Val Glu Cys
            500                 505                 510         
Thr Val Thr Tyr Glu Ser Asp Val Arg Thr Pro Lys Ser Thr Lys His
        515                 520                 525             
Val His Leu Ile Gln Trp Ser Arg Thr Lys Pro Gln Asp Glu Val Lys
    530                 535                 540                 
Ala Val Gln Leu Ala Ile Gln Thr Leu Phe Thr Asn Ser Asp Gly Asn
545                 550                 555                 560 
Pro Gly Ser Arg Ser Asp Ser Ser Ala Asp Cys Gln Trp Leu Asp Thr
                565                 570                 575     
Leu Arg Met Arg Gln Ile Ala Ser Asn Thr Ser Leu Gln Arg Ser Gln
            580                 585                 590         
Ser Asn Pro Ile Leu Gly Ser Pro Phe Phe Ser His Phe Asp Gly Gln
        595                 600                 605             
Asp Ser Tyr Ala Ala Ala Val Arg Arg Pro Gln Val Pro Ile Lys Tyr
    610                 615                 620                 
Gln Gln Ile Thr Pro Val Asn Gln Ser Arg Ser Ser Ser Pro Thr Gln
625                 630                 635                 640 
Tyr Gly Leu Thr Lys Asn Phe Ser Ser Leu His Leu Asn Ser Arg Asp
                645                 650                 655     
Ser Gly Phe Ser Ser Gly Asn Thr Asp Thr Ser Ser Glu Arg Gly Arg
            660                 665                 670         
Tyr Ser Asp Arg Ser Arg Asn Lys Tyr Gly Arg Gly Ser Ile Ser Leu
        675                 680                 685             
Asn Ser Ser Pro Arg Gly Arg Tyr Ser Gly Lys Ser Gln His Ser Thr
    690                 695                 700                 
Pro Ser Arg Gly Arg Tyr Pro Gly Lys Phe Tyr Arg Val Ser Gln Ser
705                 710                 715                 720 
Ala Leu Asn Pro His Gln Ser Pro Asp Phe Lys Arg Ser Pro Arg Asp
                725                 730                 735     
Leu His Gln Pro Asn Thr Ile Pro Gly Met Pro Leu His Pro Glu Thr
            740                 745                 750         
Asp Ser Arg Ala Ser Glu Glu Asp Ser Lys Val Ser Glu Gly Gly Trp
        755                 760                 765             
Thr Lys Val Glu Tyr Arg Lys Lys Pro His Arg Pro Ser Pro Ala Lys
    770                 775                 780                 
Thr Asn Lys Glu Arg Ala Arg Gly Asp His Arg Gly Trp Arg Asn Phe
785                 790                 795                 800 


<210> 1102
<211> 2048
<212> PRT
<213> Homo sapiens

<400> 1102
Met Leu Arg Val Ile Val Glu Ser Ala Ser Asn Ile Pro Lys Thr Lys
 1               5                  10                  15      
Phe Gly Lys Pro Asp Pro Ile Val Ser Val Ile Phe Lys Asp Glu Lys
            20                  25                  30          
Lys Lys Thr Lys Lys Val Asp Asn Glu Leu Asn Pro Val Trp Asn Glu
        35                  40                  45              
Ile Leu Glu Phe Asp Leu Arg Gly Ile Pro Leu Asp Phe Ser Ser Ser
    50                  55                  60                  
Leu Gly Ile Ile Val Lys Asp Phe Glu Thr Ile Gly Gln Asn Lys Leu
65                  70                  75                  80  
Ile Gly Thr Ala Thr Val Ala Leu Lys Asp Leu Thr Gly Asp Gln Ser
                85                  90                  95      
Arg Ser Leu Pro Tyr Lys Leu Ile Ser Leu Leu Asn Glu Lys Gly Gln
            100                 105                 110         
Asp Thr Gly Ala Thr Ile Asp Leu Val Ile Gly Tyr Asp Pro Pro Ser
        115                 120                 125             
Ala Pro His Pro Asn Asp Leu Ser Gly Pro Ser Val Pro Gly Met Gly
    130                 135                 140                 
Gly Asp Gly Glu Glu Asp Glu Gly Asp Glu Asp Arg Leu Asp Asn Ala
145                 150                 155                 160 
Val Arg Gly Pro Gly Pro Lys Gly Pro Val Gly Thr Val Ser Glu Ala
                165                 170                 175     
Gln Leu Ala Arg Arg Leu Thr Lys Val Lys Asn Ser Arg Arg Met Leu
            180                 185                 190         
Ser Asn Lys Pro Gln Asp Phe Gln Ile Arg Val Arg Val Ile Glu Gly
        195                 200                 205             
Arg Gln Leu Ser Gly Asn Asn Ile Arg Pro Val Val Lys Val His Val
    210                 215                 220                 
Cys Gly Gln Thr His Arg Thr Arg Ile Lys Arg Gly Asn Asn Pro Phe
225                 230                 235                 240 
Phe Asp Glu Leu Phe Phe Tyr Asn Val Asn Thr Thr Pro Ser Glu Leu
                245                 250                 255     
Met Asp Glu Ile Ile Ser Ile Arg Val Tyr Asn Ser His Ser Leu Arg
            260                 265                 270         
Ala Asp Cys Leu Met Gly Glu Phe Lys Ile Asp Val Gly Phe Val Tyr
        275                 280                 285             
Asp Glu Pro Gly His Ala Val Met Arg Lys Trp Leu Leu Leu Asn Asp
    290                 295                 300                 
Pro Glu Asp Thr Ser Ser Gly Ser Lys Gly Tyr Met Lys Val Ser Met
305                 310                 315                 320 
Phe Val Leu Gly Thr Gly Asp Glu Pro Pro Pro Glu Arg Arg Asp Arg
                325                 330                 335     
Asp Asn Asp Ser Asp Asp Val Glu Ser Asn Leu Leu Leu Pro Ala Gly
            340                 345                 350         
Ile Ala Leu Arg Trp Val Thr Phe Leu Leu Lys Ile Tyr Arg Ala Glu
        355                 360                 365             
Asp Ile Pro Gln Met Asp Asp Ala Phe Ser Gln Thr Val Lys Glu Ile
    370                 375                 380                 
Phe Gly Gly Asn Ala Asp Lys Lys Asn Leu Val Asp Pro Phe Val Glu
385                 390                 395                 400 
Val Ser Phe Ala Gly Lys Lys Val Cys Thr Asn Ile Ile Glu Lys Asn
                405                 410                 415     
Ala Asn Pro Glu Trp Asn Gln Val Val Asn Leu Gln Ile Lys Phe Pro
            420                 425                 430         
Ser Val Cys Glu Lys Ile Lys Leu Thr Ile Tyr Asp Trp Asp Arg Leu
        435                 440                 445             
Thr Lys Asn Asp Val Val Gly Thr Thr Tyr Leu His Leu Ser Lys Ile
    450                 455                 460                 
Ala Ala Ser Gly Gly Glu Val Glu Val Asn Thr Gly Glu Thr Glu Val
465                 470                 475                 480 
Gly Phe Val Pro Thr Phe Gly Pro Cys Tyr Leu Asn Leu Tyr Gly Ser
                485                 490                 495     
Pro Arg Glu Tyr Thr Gly Phe Pro Asp Pro Tyr Asp Glu Leu Asn Thr
            500                 505                 510         
Gly Lys Gly Glu Gly Val Ala Tyr Arg Gly Arg Ile Leu Val Glu Leu
        515                 520                 525             
Ala Thr Phe Leu Glu Lys Thr Pro Pro Asp Lys Lys Leu Glu Pro Ile
    530                 535                 540                 
Ser Asn Asp Asp Leu Leu Val Val Glu Lys Tyr Gln Arg Arg Arg Lys
545                 550                 555                 560 
Tyr Ser Leu Ser Ala Val Phe His Ser Ala Thr Met Leu Gln Asp Val
                565                 570                 575     
Gly Glu Ala Ile Gln Phe Glu Val Ser Ile Gly Asn Tyr Gly Asn Lys
            580                 585                 590         
Phe Asp Thr Thr Cys Lys Pro Leu Ala Ser Thr Thr Gln Tyr Ser Arg
        595                 600                 605             
Ala Val Phe Asp Gly Asn Tyr Tyr Tyr Tyr Leu Pro Trp Ala His Thr
    610                 615                 620                 
Lys Pro Val Val Thr Leu Thr Ser Tyr Trp Glu Asp Ile Ser His Arg
625                 630                 635                 640 
Leu Asp Ala Val Asn Ala Leu Leu Ala Met Ala Glu Arg Leu Gln Thr
                645                 650                 655     
Asn Ile Glu Ala Leu Lys Ser Gly Ile Gln Gly Lys Ile Pro Ala Asn
            660                 665                 670         
Gln Leu Ala Glu Leu Trp Leu Lys Leu Ile Asp Glu Val Ile Glu Asp
        675                 680                 685             
Thr Arg Tyr Thr Leu Pro Leu Thr Glu Gly Lys Ala Asn Val Thr Val
    690                 695                 700                 
Leu Asp Thr Gln Ile Arg Lys Leu Arg Ser Arg Ser Leu Ser Gln Ile
705                 710                 715                 720 
His Glu Ala Ala Val Arg Met Arg Ser Glu Ala Thr Asp Val Lys Ser
                725                 730                 735     
Thr Leu Ala Glu Ile Glu Asp Trp Leu Asp Lys Leu Met Gln Leu Thr
            740                 745                 750         
Glu Glu Pro Gln Asn Ser Met Pro Asp Ile Ile Ile Trp Met Ile Arg
        755                 760                 765             
Gly Glu Lys Arg Leu Ala Tyr Ala Arg Ile Pro Ala His Gln Val Leu
    770                 775                 780                 
Tyr Ser Thr Ser Gly Glu Asn Ala Ser Gly Lys Tyr Cys Gly Lys Thr
785                 790                 795                 800 
Gln Thr Ile Phe Leu Lys Tyr Pro Gln Glu Lys Asn Asn Gly Pro Lys
                805                 810                 815     
Val Pro Val Glu Leu Arg Val Asn Ile Trp Leu Gly Leu Ser Ala Val
            820                 825                 830         
Glu Lys Lys Phe Asn Ser Phe Ala Glu Gly Thr Phe Thr Val Phe Ala
        835                 840                 845             
Glu Met Tyr Glu Asn Gln Ala Leu Met Phe Gly Lys Trp Gly Thr Ser
    850                 855                 860                 
Gly Leu Val Gly Arg His Lys Phe Ser Asp Val Thr Gly Lys Ile Lys
865                 870                 875                 880 
Leu Lys Arg Glu Phe Phe Leu Pro Pro Lys Gly Trp Glu Trp Glu Gly
                885                 890                 895     
Glu Trp Ile Val Asp Pro Glu Arg Ser Leu Leu Thr Glu Ala Asp Ala
            900                 905                 910         
Gly His Thr Glu Phe Thr Asp Glu Val Tyr Gln Asn Glu Ser Arg Tyr
        915                 920                 925             
Pro Gly Gly Asp Trp Lys Pro Ala Glu Asp Thr Tyr Thr Asp Ala Asn
    930                 935                 940                 
Gly Asp Lys Ala Ala Ser Pro Ser Glu Leu Thr Cys Pro Pro Gly Trp
945                 950                 955                 960 
Glu Trp Glu Asp Asp Ala Trp Ser Tyr Asp Ile Asn Arg Ala Val Asp
                965                 970                 975     
Glu Lys Gly Trp Glu Tyr Gly Ile Thr Ile Pro Pro Asp His Lys Pro
            980                 985                 990         
Lys Ser Trp Val Ala Ala Glu Lys Met Tyr His Thr His Arg Arg Arg
        995                 1000                1005            
Arg Leu Val Arg Lys Arg Lys Lys Asp Leu Thr Gln Thr Ala Ser Ser
    1010                1015                1020                
Thr Ala Arg Ala Met Glu Glu Leu Gln Asp Gln Glu Gly Trp Glu Tyr
1025                1030                1035                1040
Ala Ser Leu Ile Gly Trp Lys Phe His Trp Lys Gln Arg Ser Ser Asp
                1045                1050                1055    
Thr Phe Arg Arg Arg Arg Trp Arg Arg Lys Met Ala Pro Ser Glu Thr
            1060                1065                1070        
His Gly Ala Ala Ala Ile Phe Lys Leu Glu Gly Ala Leu Gly Ala Asp
        1075                1080                1085            
Thr Thr Glu Asp Gly Asp Glu Lys Ser Leu Glu Lys Gln Lys His Ser
    1090                1095                1100                
Ala Thr Thr Val Phe Gly Ala Asn Thr Pro Ile Val Ser Cys Asn Phe
1105                1110                1115                1120
Asp Arg Val Tyr Ile Tyr His Leu Arg Cys Tyr Val Tyr Gln Ala Arg
                1125                1130                1135    
Asn Leu Leu Ala Leu Asp Lys Asp Ser Phe Ser Asp Pro Tyr Ala His
            1140                1145                1150        
Ile Cys Phe Leu His Arg Ser Lys Thr Thr Glu Ile Ile His Ser Thr
        1155                1160                1165            
Leu Asn Pro Thr Trp Asp Gln Thr Ile Ile Phe Asp Glu Val Glu Ile
    1170                1175                1180                
Tyr Gly Glu Pro Gln Thr Val Leu Gln Asn Pro Pro Lys Val Ile Met
1185                1190                1195                1200
Glu Leu Phe Asp Asn Asp Gln Val Gly Lys Asp Glu Phe Leu Gly Arg
                1205                1210                1215    
Ser Ile Phe Ser Pro Val Val Lys Leu Asn Ser Glu Met Asp Ile Thr
            1220                1225                1230        
Pro Lys Leu Leu Trp His Pro Val Met Asn Gly Asp Lys Ala Cys Gly
        1235                1240                1245            
Asp Val Leu Val Thr Ala Glu Leu Ile Leu Arg Gly Lys Asp Gly Ser
    1250                1255                1260                
Asn Leu Pro Ile Leu Pro Pro Gln Arg Ala Pro Asn Leu Tyr Met Val
1265                1270                1275                1280
Pro Gln Gly Ile Arg Pro Val Val Gln Leu Thr Ala Ile Glu Ile Leu
                1285                1290                1295    
Ala Trp Gly Leu Arg Asn Met Lys Asn Phe Gln Met Ala Ser Ile Thr
            1300                1305                1310        
Ser Pro Ser Leu Val Val Glu Cys Gly Gly Glu Arg Val Glu Ser Val
        1315                1320                1325            
Val Ile Lys Asn Leu Lys Lys Thr Pro Asn Phe Pro Ser Ser Val Leu
    1330                1335                1340                
Phe Met Lys Val Phe Leu Pro Lys Glu Glu Leu Tyr Met Pro Pro Leu
1345                1350                1355                1360
Val Ile Lys Val Ile Asp His Arg Gln Phe Gly Arg Lys Pro Val Val
                1365                1370                1375    
Gly Gln Cys Thr Ile Glu Arg Leu Asp Arg Phe Arg Cys Asp Pro Tyr
            1380                1385                1390        
Ala Gly Lys Glu Asp Ile Val Pro Gln Leu Lys Ala Ser Leu Leu Ser
        1395                1400                1405            
Ala Pro Pro Cys Arg Asp Ile Val Ile Glu Met Glu Asp Thr Lys Pro
    1410                1415                1420                
Leu Leu Ala Ser Lys Leu Thr Glu Lys Glu Glu Glu Ile Val Asp Trp
1425                1430                1435                1440
Trp Ser Lys Phe Tyr Ala Ser Ser Gly Glu His Glu Lys Cys Gly Gln
                1445                1450                1455    
Tyr Ile Gln Lys Gly Tyr Ser Lys Leu Lys Ile Tyr Asn Cys Glu Leu
            1460                1465                1470        
Glu Asn Val Ala Glu Phe Glu Gly Leu Thr Asp Phe Ser Asp Thr Phe
        1475                1480                1485            
Lys Leu Tyr Arg Gly Lys Ser Asp Glu Asn Glu Asp Pro Ser Val Val
    1490                1495                1500                
Gly Glu Phe Lys Gly Ser Phe Arg Ile Tyr Pro Leu Pro Asp Asp Pro
1505                1510                1515                1520
Ser Val Pro Ala Pro Pro Arg Gln Phe Arg Gly Leu Pro Asp Ser Val
                1525                1530                1535    
Pro Gln Glu Cys Thr Val Arg Ile Tyr Ile Val Arg Gly Leu Glu Leu
            1540                1545                1550        
Gln Pro Gln Asp Asn Asn Gly Leu Cys Asp Pro Tyr Ile Lys Ile Thr
        1555                1560                1565            
Leu Gly Lys Lys Val Ile Glu Asp Arg Asp His Tyr Ile Pro Asn Thr
    1570                1575                1580                
Leu Asn Pro Val Phe Gly Arg Met Tyr Glu Leu Ser Cys Tyr Leu Pro
1585                1590                1595                1600
Gln Glu Lys Asp Leu Lys Ile Ser Val Tyr Asp Tyr Asp Thr Phe Thr
                1605                1610                1615    
Arg Asp Glu Lys Val Gly Glu Thr Ile Ile Asp Leu Glu Asn Arg Phe
            1620                1625                1630        
Leu Ser Arg Phe Gly Ser His Cys Gly Ile Pro Glu Glu Tyr Cys Val
        1635                1640                1645            
Ser Gly Val Asn Thr Trp Arg Asp Gln Leu Arg Pro Thr Gln Leu Leu
    1650                1655                1660                
Gln Asn Val Ala Arg Phe Lys Gly Phe Pro Gln Pro Ile Leu Ser Glu
1665                1670                1675                1680
Asp Gly Ser Arg Ile Arg Tyr Gly Gly Arg Asp Tyr Ser Leu Asp Glu
                1685                1690                1695    
Phe Glu Ala Asn Lys Ile Leu His Gln His Leu Gly Ala Pro Glu Glu
            1700                1705                1710        
Arg Leu Ala Leu His Ile Leu Arg Thr Gln Gly Leu Val Pro Glu His
        1715                1720                1725            
Val Glu Thr Arg Thr Leu His Ser Thr Phe Gln Pro Asn Ile Ser Gln
    1730                1735                1740                
Gly Lys Leu Gln Met Trp Val Asp Val Phe Pro Lys Ser Leu Gly Pro
1745                1750                1755                1760
Pro Gly Pro Pro Phe Asn Ile Thr Pro Arg Lys Ala Lys Lys Tyr Tyr
                1765                1770                1775    
Leu Arg Val Ile Ile Trp Asn Thr Lys Asp Val Ile Leu Asp Glu Lys
            1780                1785                1790        
Ser Ile Thr Gly Glu Glu Met Ser Asp Ile Tyr Val Lys Gly Trp Ile
        1795                1800                1805            
Pro Gly Asn Glu Glu Asn Lys Gln Lys Thr Asp Val His Tyr Arg Ser
    1810                1815                1820                
Leu Asp Gly Glu Gly Asn Phe Asn Trp Arg Phe Val Phe Pro Phe Asp
1825                1830                1835                1840
Tyr Leu Pro Ala Glu Gln Leu Cys Ile Val Ala Lys Lys Glu His Phe
                1845                1850                1855    
Trp Ser Ile Asp Gln Thr Glu Phe Arg Ile Pro Pro Arg Leu Ile Ile
            1860                1865                1870        
Gln Ile Trp Asp Asn Asp Lys Phe Ser Leu Asp Asp Tyr Leu Gly Phe
        1875                1880                1885            
Leu Glu Leu Asp Leu Arg His Thr Ile Ile Pro Ala Lys Ser Pro Glu
    1890                1895                1900                
Lys Cys Arg Leu Asp Met Ile Pro Asp Leu Lys Ala Met Asn Pro Leu
1905                1910                1915                1920
Lys Ala Lys Thr Ala Ser Leu Phe Glu Gln Lys Ser Met Lys Gly Trp
                1925                1930                1935    
Trp Pro Cys Tyr Ala Glu Lys Asp Gly Ala Arg Val Met Ala Gly Lys
            1940                1945                1950        
Val Glu Met Thr Leu Glu Ile Leu Asn Glu Lys Glu Ala Asp Glu Arg
        1955                1960                1965            
Pro Ala Gly Lys Gly Arg Asp Glu Pro Asn Met Asn Pro Lys Leu Asp
    1970                1975                1980                
Leu Pro Asn Arg Pro Glu Thr Ser Phe Leu Trp Phe Thr Asn Pro Cys
1985                1990                1995                2000
Lys Thr Met Lys Phe Ile Val Trp Arg Arg Phe Lys Trp Val Ile Ile
                2005                2010                2015    
Gly Leu Leu Phe Leu Leu Ile Leu Leu Leu Phe Val Ala Val Leu Leu
            2020                2025                2030        
Tyr Ser Leu Pro Asn Tyr Leu Ser Met Lys Ile Val Lys Pro Asn Val
        2035                2040                2045            


<210> 1103
<211> 171
<212> PRT
<213> Homo sapiens

<400> 1103
Met Leu Val Ile Glu Gln Cys Lys Asn Ser Arg Ala Val Thr Ile Phe
 1               5                  10                  15      
Ile Arg Gly Gly Asn Lys Met Ile Ile Glu Glu Ala Lys Arg Ser Leu
            20                  25                  30          
His Asp Ala Leu Cys Val Ile Arg Asn Leu Ile Arg Asp Asn Arg Val
        35                  40                  45              
Val Tyr Gly Gly Gly Ala Ala Glu Ile Ser Cys Ala Leu Ala Val Ser
    50                  55                  60                  
Gln Glu Ala Asp Lys Cys Pro Thr Leu Glu Gln Tyr Ala Met Arg Ala
65                  70                  75                  80  
Phe Ala Asp Ala Leu Glu Val Ile Pro Met Ala Leu Ser Glu Asn Ser
                85                  90                  95      
Gly Met Asn Pro Ile Gln Thr Met Thr Glu Val Arg Ala Arg Gln Val
            100                 105                 110         
Lys Glu Met Asn Pro Ala Leu Gly Ile Asp Cys Leu His Lys Gly Thr
        115                 120                 125             
Asn Asp Met Lys Gln Gln His Val Ile Glu Thr Leu Ile Gly Lys Lys
    130                 135                 140                 
Gln Gln Ile Ser Leu Ala Thr Gln Met Val Arg Met Ile Leu Lys Ile
145                 150                 155                 160 
Asp Asp Ile Arg Lys Pro Gly Glu Ser Glu Glu
                165                 170     


<210> 1104
<211> 63
<212> PRT
<213> Homo sapiens

<400> 1104
Met Ser Leu Arg Asn Leu Trp Arg Asp Tyr Lys Val Leu Val Val Met
 1               5                  10                  15      
Val Pro Leu Val Gly Leu Ile His Leu Gly Trp Tyr Arg Ile Lys Ser
            20                  25                  30          
Ser Pro Val Phe Gln Ile Pro Lys Asn Asp Asp Ile Pro Glu Gln Asp
        35                  40                  45              
Ser Leu Gly Leu Ser Asn Leu Gln Lys Ser Gln Ile Gln Gly Lys
    50                  55                  60              


<210> 1105
<211> 1010
<212> PRT
<213> Homo sapiens

<400> 1105
Met Gly Tyr Ala Arg Ala Ser Gly Val Cys Ala Arg Gly Cys Leu Asp
 1               5                  10                  15      
Ser Ala Gly Pro Trp Thr Met Ser Arg Ala Leu Arg Pro Pro Leu Pro
            20                  25                  30          
Pro Leu Cys Phe Phe Leu Leu Leu Leu Ala Ala Ala Gly Ala Arg Ala
        35                  40                  45              
Gly Gly Tyr Glu Thr Cys Pro Thr Val Gln Pro Asn Met Leu Asn Val
    50                  55                  60                  
His Leu Leu Pro His Thr His Asp Asp Val Gly Trp Leu Lys Thr Val
65                  70                  75                  80  
Asp Gln Tyr Phe Tyr Gly Ile Lys Asn Asp Ile Gln His Ala Gly Val
                85                  90                  95      
Gln Tyr Ile Leu Asp Ser Val Ile Ser Ala Leu Leu Ala Asp Pro Thr
            100                 105                 110         
Arg Arg Phe Ile Tyr Val Glu Ile Ala Phe Phe Ser Arg Trp Trp His
        115                 120                 125             
Gln Gln Thr Asn Ala Thr Gln Glu Val Val Arg Asp Leu Val Arg Gln
    130                 135                 140                 
Gly Arg Leu Glu Phe Ala Asn Gly Gly Trp Val Met Asn Asp Glu Ala
145                 150                 155                 160 
Ala Thr His Tyr Gly Ala Ile Val Asp Gln Met Thr Leu Gly Leu Arg
                165                 170                 175     
Phe Leu Glu Asp Thr Phe Gly Asn Asp Gly Arg Pro Arg Val Ala Trp
            180                 185                 190         
His Ile Asp Pro Phe Gly His Ser Arg Glu Gln Ala Ser Leu Phe Ala
        195                 200                 205             
Gln Met Gly Phe Asp Gly Phe Phe Phe Gly Arg Leu Asp Tyr Gln Asp
    210                 215                 220                 
Lys Trp Val Arg Met Gln Lys Leu Glu Met Glu Gln Val Trp Arg Ala
225                 230                 235                 240 
Ser Thr Ser Leu Lys Pro Pro Thr Ala Asp Leu Phe Thr Gly Val Leu
                245                 250                 255     
Pro Asn Gly Tyr Asn Pro Pro Arg Asn Leu Cys Trp Asp Val Leu Cys
            260                 265                 270         
Val Asp Gln Pro Leu Val Glu Asp Pro Arg Ser Pro Glu Tyr Asn Ala
        275                 280                 285             
Lys Glu Leu Val Asp Tyr Phe Leu Asn Val Ala Thr Ala Gln Gly Arg
    290                 295                 300                 
Tyr Tyr Arg Thr Asn His Thr Val Met Thr Met Gly Ser Asp Phe Gln
305                 310                 315                 320 
Tyr Glu Asn Ala Asn Met Trp Phe Lys Asn Leu Asp Lys Leu Ile Arg
                325                 330                 335     
Leu Val Asn Ala Gln Gln Ala Lys Gly Ser Ser Val His Val Leu Tyr
            340                 345                 350         
Ser Thr Pro Ala Cys Tyr Leu Trp Glu Leu Asn Lys Ala Asn Leu Thr
        355                 360                 365             
Trp Ser Val Lys His Asp Asp Phe Phe Pro Tyr Ala Asp Gly Pro His
    370                 375                 380                 
Gln Phe Trp Thr Gly Tyr Phe Ser Ser Arg Pro Ala Leu Lys Arg Tyr
385                 390                 395                 400 
Glu Arg Leu Ser Tyr Asn Phe Leu Gln Val Cys Asn Gln Leu Glu Ala
                405                 410                 415     
Leu Val Gly Leu Ala Ala Asn Val Gly Pro Tyr Gly Ser Gly Asp Ser
            420                 425                 430         
Ala Pro Leu Asn Glu Ala Met Ala Val Leu Gln His His Asp Ala Val
        435                 440                 445             
Ser Gly Thr Ser Arg Gln His Val Ala Asn Asp Tyr Ala Arg Gln Leu
    450                 455                 460                 
Ala Ala Gly Trp Gly Pro Cys Glu Val Leu Leu Ser Asn Ala Leu Ala
465                 470                 475                 480 
Arg Leu Arg Gly Phe Lys Asp His Phe Thr Phe Cys Gln Gln Leu Asn
                485                 490                 495     
Ile Ser Ile Cys Pro Leu Ser Gln Thr Ala Ala Arg Phe Gln Val Ile
            500                 505                 510         
Val Tyr Asn Pro Leu Gly Arg Lys Val Asn Trp Met Val Arg Leu Pro
        515                 520                 525             
Val Ser Glu Gly Val Phe Val Val Lys Asp Pro Asn Gly Arg Thr Val
    530                 535                 540                 
Pro Ser Asp Val Val Ile Phe Pro Ser Ser Asp Ser Gln Ala His Pro
545                 550                 555                 560 
Pro Glu Leu Leu Phe Ser Ala Ser Leu Pro Ala Leu Gly Phe Ser Thr
                565                 570                 575     
Tyr Ser Val Ala Gln Val Pro Arg Trp Lys Pro Gln Ala Arg Ala Pro
            580                 585                 590         
Gln Pro Ile Pro Arg Arg Ser Trp Ser Pro Ala Leu Thr Ile Glu Asn
        595                 600                 605             
Glu His Ile Arg Ala Thr Phe Asp Pro Asp Thr Gly Leu Leu Met Glu
    610                 615                 620                 
Ile Met Asn Met Asn Gln Gln Leu Leu Leu Pro Val Arg Gln Thr Phe
625                 630                 635                 640 
Phe Trp Tyr Asn Ala Ser Ile Gly Asp Asn Glu Ser Asp Gln Ala Ser
                645                 650                 655     
Gly Ala Tyr Ile Phe Arg Pro Asn Gln Gln Lys Pro Leu Pro Val Ser
            660                 665                 670         
Arg Trp Ala Gln Ile His Leu Val Lys Thr Pro Leu Val Gln Glu Val
        675                 680                 685             
His Gln Asn Phe Ser Ala Trp Cys Ser Gln Val Val Arg Leu Tyr Pro
    690                 695                 700                 
Gly Gln Arg His Leu Glu Leu Glu Trp Ser Val Gly Pro Ile Pro Val
705                 710                 715                 720 
Gly Asp Thr Trp Gly Lys Glu Val Ile Ser Arg Phe Asp Thr Pro Leu
                725                 730                 735     
Glu Thr Lys Gly Arg Phe Tyr Thr Asp Ser Asn Gly Arg Glu Ile Leu
            740                 745                 750         
Glu Arg Arg Arg Asp Tyr Arg Pro Thr Trp Lys Leu Asn Gln Thr Glu
        755                 760                 765             
Pro Val Ala Gly Asn Tyr Tyr Pro Val Asn Thr Arg Ile Tyr Ile Thr
    770                 775                 780                 
Asp Gly Asn Met Gln Leu Thr Val Leu Thr Asp Arg Ser Gln Gly Gly
785                 790                 795                 800 
Ser Ser Leu Arg Asp Gly Ser Leu Glu Leu Met Val His Arg Arg Leu
                805                 810                 815     
Leu Lys Asp Asp Gly Arg Gly Val Ser Glu Pro Leu Met Glu Asn Gly
            820                 825                 830         
Ser Gly Ala Trp Val Arg Gly Arg His Leu Val Leu Leu Asp Thr Ala
        835                 840                 845             
Gln Ala Ala Ala Ala Gly His Arg Leu Leu Ala Glu Gln Glu Val Leu
    850                 855                 860                 
Ala Pro Gln Val Val Leu Ala Pro Gly Gly Gly Ala Ala Tyr Asn Leu
865                 870                 875                 880 
Gly Ala Pro Pro Arg Thr Gln Phe Ser Gly Leu Arg Arg Asp Leu Pro
                885                 890                 895     
Pro Ser Val His Leu Leu Thr Leu Ala Ser Trp Gly Pro Glu Met Val
            900                 905                 910         
Leu Leu Arg Leu Glu His Gln Phe Ala Val Gly Glu Asp Ser Gly Arg
        915                 920                 925             
Asn Leu Ser Ala Pro Val Thr Leu Asn Leu Arg Asp Leu Phe Ser Thr
    930                 935                 940                 
Phe Thr Ile Thr Arg Leu Gln Glu Thr Thr Leu Val Ala Asn Gln Leu
945                 950                 955                 960 
Arg Glu Ala Ala Ser Arg Leu Lys Trp Thr Thr Asn Thr Gly Pro Thr
                965                 970                 975     
Pro His Gln Thr Pro Tyr Gln Leu Asp Pro Ala Asn Ile Thr Leu Glu
            980                 985                 990         
Pro Met Glu Ile Arg Thr Phe Leu Ala Ser Val Gln Trp Lys Glu Val
        995                 1000                1005            
Asp Gly
    1010


<210> 1106
<211> 465
<212> PRT
<213> Homo sapiens

<400> 1106
Met Leu Pro Leu Trp Thr Leu Ser Leu Leu Leu Gly Ala Val Ala Gly
 1               5                  10                  15      
Lys Glu Val Cys Tyr Glu Arg Leu Gly Cys Phe Ser Asp Asp Ser Pro
            20                  25                  30          
Trp Ser Gly Ile Thr Glu Arg Pro Leu His Ile Leu Pro Trp Ser Pro
        35                  40                  45              
Lys Asp Val Asn Thr Arg Phe Leu Leu Tyr Thr Asn Glu Asn Pro Asn
    50                  55                  60                  
Asn Phe Gln Glu Val Ala Ala Asp Ser Ser Ser Ile Ser Gly Ser Asn
65                  70                  75                  80  
Phe Lys Thr Asn Arg Lys Thr Arg Phe Ile Ile His Gly Phe Ile Asp
                85                  90                  95      
Lys Gly Glu Glu Asn Trp Leu Ala Asn Val Cys Lys Asn Leu Phe Lys
            100                 105                 110         
Val Glu Ser Val Asn Cys Ile Cys Val Asp Trp Lys Gly Gly Ser Arg
        115                 120                 125             
Thr Gly Tyr Thr Gln Ala Ser Gln Asn Ile Arg Ile Val Gly Ala Glu
    130                 135                 140                 
Val Ala Tyr Phe Val Glu Phe Leu Gln Ser Ala Phe Gly Tyr Ser Pro
145                 150                 155                 160 
Ser Asn Val His Val Ile Gly His Ser Leu Gly Ala His Ala Ala Gly
                165                 170                 175     
Glu Ala Gly Arg Arg Thr Asn Gly Thr Ile Gly Arg Ile Thr Gly Leu
            180                 185                 190         
Asp Pro Ala Glu Pro Cys Phe Gln Gly Thr Pro Glu Leu Val Arg Leu
        195                 200                 205             
Asp Pro Ser Asp Ala Lys Phe Val Asp Val Ile His Thr Asp Gly Ala
    210                 215                 220                 
Pro Ile Val Pro Asn Leu Gly Phe Gly Met Ser Gln Val Val Gly His
225                 230                 235                 240 
Leu Asp Phe Phe Pro Asn Gly Gly Val Glu Met Pro Gly Cys Lys Lys
                245                 250                 255     
Asn Ile Leu Ser Gln Ile Val Asp Ile Asp Gly Ile Trp Glu Gly Thr
            260                 265                 270         
Arg Asp Phe Ala Ala Cys Asn His Leu Arg Ser Tyr Lys Tyr Tyr Thr
        275                 280                 285             
Asp Ser Ile Val Asn Pro Asp Gly Phe Ala Gly Phe Pro Cys Ala Ser
    290                 295                 300                 
Tyr Asn Val Phe Thr Ala Asn Lys Cys Phe Pro Cys Pro Ser Gly Gly
305                 310                 315                 320 
Cys Pro Gln Met Gly His Tyr Ala Asp Arg Tyr Pro Gly Lys Thr Asn
                325                 330                 335     
Asp Val Gly Gln Lys Phe Tyr Leu Asp Thr Gly Asp Ala Ser Asn Phe
            340                 345                 350         
Ala Arg Trp Arg Tyr Lys Val Ser Val Thr Leu Ser Gly Lys Lys Val
        355                 360                 365             
Thr Gly His Ile Leu Val Ser Leu Phe Gly Asn Lys Gly Asn Ser Lys
    370                 375                 380                 
Gln Tyr Glu Ile Phe Lys Gly Thr Leu Lys Pro Asp Ser Thr His Ser
385                 390                 395                 400 
Asn Glu Phe Asp Ser Asp Val Asp Val Gly Asp Leu Gln Met Val Lys
                405                 410                 415     
Phe Ile Trp Tyr Asn Asn Val Ile Asn Pro Thr Leu Pro Arg Val Gly
            420                 425                 430         
Ala Ser Lys Ile Ile Val Glu Thr Asn Val Gly Lys Gln Phe Asn Phe
        435                 440                 445             
Cys Ser Pro Glu Thr Val Arg Glu Glu Val Leu Leu Thr Leu Thr Pro
    450                 455                 460                 
Cys
465 


<210> 1107
<211> 201
<212> PRT
<213> Homo sapiens

<400> 1107
Met Thr Glu Lys Ala Pro Glu Pro His Val Glu Glu Asp Asp Asp Asp
 1               5                  10                  15      
Glu Leu Asp Ser Lys Leu Asn Tyr Lys Pro Pro Pro Gln Lys Ser Leu
            20                  25                  30          
Lys Glu Leu Gln Glu Met Asp Lys Asp Asp Glu Ser Leu Ile Lys Tyr
        35                  40                  45              
Lys Lys Thr Leu Leu Gly Asp Gly Pro Val Val Thr Asp Pro Lys Ala
    50                  55                  60                  
Pro Asn Val Val Val Thr Arg Leu Thr Leu Val Cys Glu Ser Ala Pro
65                  70                  75                  80  
Gly Pro Ile Thr Met Asp Leu Thr Gly Asp Leu Glu Ala Leu Lys Lys
                85                  90                  95      
Glu Thr Ile Val Leu Lys Glu Gly Ser Glu Tyr Arg Val Lys Ile His
            100                 105                 110         
Phe Lys Val Asn Arg Asp Ile Val Ser Gly Leu Lys Tyr Val Gln His
        115                 120                 125             
Thr Tyr Arg Thr Gly Val Lys Val Asp Lys Ala Thr Phe Met Val Gly
    130                 135                 140                 
Ser Tyr Gly Pro Arg Pro Glu Glu Tyr Glu Phe Leu Thr Pro Val Glu
145                 150                 155                 160 
Glu Ala Pro Lys Gly Met Leu Ala Arg Gly Thr Tyr His Asn Lys Ser
                165                 170                 175     
Phe Phe Thr Asp Asp Asp Lys Gln Asp His Leu Ser Trp Glu Trp Asn
            180                 185                 190         
Leu Ser Ile Lys Lys Glu Trp Thr Glu
        195                 200     


<210> 1108
<211> 2695
<212> PRT
<213> Homo sapiens

<400> 1108
Met Ser Asp Lys Met Ser Ser Phe Leu His Ile Gly Asp Ile Cys Ser
 1               5                  10                  15      
Leu Tyr Ala Glu Gly Ser Thr Asn Gly Phe Ile Ser Thr Leu Gly Leu
            20                  25                  30          
Val Asp Asp Arg Cys Val Val Gln Pro Glu Thr Gly Asp Leu Asn Asn
        35                  40                  45              
Pro Pro Lys Lys Phe Arg Asp Cys Leu Phe Lys Leu Cys Pro Met Asn
    50                  55                  60                  
Arg Tyr Ser Ala Gln Lys Gln Phe Trp Lys Ala Ala Lys Pro Gly Ala
65                  70                  75                  80  
Asn Ser Thr Thr Asp Ala Val Leu Leu Asn Lys Leu His His Ala Ala
                85                  90                  95      
Asp Leu Glu Lys Lys Gln Asn Glu Thr Glu Asn Arg Lys Leu Leu Gly
            100                 105                 110         
Thr Val Ile Gln Tyr Gly Asn Val Ile Gln Leu Leu His Leu Lys Ser
        115                 120                 125             
Asn Lys Tyr Leu Thr Val Asn Lys Arg Leu Pro Ala Leu Leu Glu Lys
    130                 135                 140                 
Asn Ala Met Arg Val Thr Leu Asp Glu Ala Gly Asn Glu Gly Ser Trp
145                 150                 155                 160 
Phe Tyr Ile Gln Pro Phe Tyr Lys Leu Arg Ser Ile Gly Asp Ser Val
                165                 170                 175     
Val Ile Gly Asp Lys Val Val Leu Asn Pro Val Asn Ala Gly Gln Pro
            180                 185                 190         
Leu His Ala Ser Ser His Gln Leu Val Asp Asn Pro Gly Cys Asn Glu
        195                 200                 205             
Val Asn Ser Val Asn Cys Asn Thr Ser Trp Lys Ile Val Leu Phe Met
    210                 215                 220                 
Lys Trp Ser Asp Asn Lys Asp Asp Ile Leu Lys Gly Gly Asp Val Val
225                 230                 235                 240 
Arg Leu Phe His Ala Glu Gln Glu Lys Phe Leu Thr Cys Asp Glu His
                245                 250                 255     
Arg Lys Lys Gln His Val Phe Leu Arg Thr Thr Gly Arg Gln Ser Ala
            260                 265                 270         
Thr Ser Ala Thr Ser Ser Lys Ala Leu Trp Glu Val Glu Val Val Gln
        275                 280                 285             
His Asp Pro Cys Arg Gly Gly Ala Gly Tyr Trp Asn Ser Leu Phe Arg
    290                 295                 300                 
Phe Lys His Leu Ala Thr Gly His Tyr Leu Ala Ala Glu Val Asp Pro
305                 310                 315                 320 
Asp Gln Asp Ala Ser Arg Ser Arg Leu Arg Asn Ala Gln Glu Lys Met
                325                 330                 335     
Val Tyr Ser Leu Val Ser Val Pro Glu Gly Asn Asp Ile Ser Ser Ile
            340                 345                 350         
Phe Glu Leu Asp Pro Thr Thr Leu Arg Gly Gly Asp Ser Leu Val Pro
        355                 360                 365             
Arg Asn Ser Tyr Val Arg Leu Arg His Leu Cys Thr Asn Thr Trp Val
    370                 375                 380                 
His Ser Thr Asn Ile Pro Ile Asp Lys Glu Glu Glu Lys Pro Val Met
385                 390                 395                 400 
Leu Lys Ile Gly Thr Ser Pro Val Lys Glu Asp Lys Glu Ala Phe Ala
                405                 410                 415     
Ile Val Pro Val Ser Pro Ala Glu Val Arg Asp Leu Asp Phe Ala Asn
            420                 425                 430         
Asp Ala Ser Lys Val Leu Gly Ser Ile Ala Gly Lys Leu Glu Lys Gly
        435                 440                 445             
Thr Ile Thr Gln Asn Glu Arg Arg Ser Val Thr Lys Leu Leu Glu Asp
    450                 455                 460                 
Leu Val Tyr Phe Val Thr Gly Gly Thr Asn Ser Gly Gln Asp Val Leu
465                 470                 475                 480 
Glu Val Val Phe Ser Lys Pro Asn Arg Glu Arg Gln Lys Leu Met Arg
                485                 490                 495     
Glu Gln Asn Ile Leu Lys Gln Ile Phe Lys Leu Leu Gln Ala Pro Phe
            500                 505                 510         
Thr Asp Cys Gly Asp Gly Pro Met Leu Arg Leu Glu Glu Leu Gly Asp
        515                 520                 525             
Gln Arg His Ala Pro Phe Arg His Ile Cys Arg Leu Cys Tyr Arg Val
    530                 535                 540                 
Leu Arg His Ser Gln Gln Asp Tyr Arg Lys Asn Gln Glu Tyr Ile Ala
545                 550                 555                 560 
Lys Gln Phe Gly Phe Met Gln Lys Gln Ile Gly Tyr Asp Val Leu Ala
                565                 570                 575     
Glu Asp Thr Ile Thr Ala Leu Leu His Asn Asn Arg Lys Leu Leu Glu
            580                 585                 590         
Lys His Ile Thr Ala Ala Glu Ile Asp Thr Phe Val Ser Leu Val Arg
        595                 600                 605             
Lys Asn Arg Glu Pro Arg Phe Leu Asp Tyr Leu Ser Asp Leu Cys Val
    610                 615                 620                 
Ser Met Asn Lys Ser Ile Pro Val Thr Gln Glu Leu Ile Cys Lys Ala
625                 630                 635                 640 
Val Leu Asn Pro Thr Asn Ala Asp Ile Leu Ile Glu Thr Lys Leu Val
                645                 650                 655     
Leu Ser Arg Phe Glu Phe Glu Gly Val Ser Ser Thr Gly Glu Asn Ala
            660                 665                 670         
Leu Glu Ala Gly Glu Asp Glu Glu Glu Val Trp Leu Phe Trp Arg Asp
        675                 680                 685             
Ser Asn Lys Glu Ile Arg Ser Lys Ser Val Arg Glu Leu Ala Gln Asp
    690                 695                 700                 
Ala Lys Glu Gly Gln Lys Glu Asp Arg Asp Val Leu Ser Tyr Tyr Arg
705                 710                 715                 720 
Tyr Gln Leu Asn Leu Phe Ala Arg Met Cys Leu Asp Arg Gln Tyr Leu
                725                 730                 735     
Ala Ile Asn Glu Ile Ser Gly Gln Leu Asp Val Asp Leu Ile Leu Arg
            740                 745                 750         
Cys Met Ser Asp Glu Asn Leu Pro Tyr Asp Leu Arg Ala Ser Phe Cys
        755                 760                 765             
Arg Leu Met Leu His Met His Val Asp Arg Asp Pro Gln Glu Gln Val
    770                 775                 780                 
Thr Pro Val Lys Tyr Ala Arg Leu Trp Ser Glu Ile Pro Ser Glu Ile
785                 790                 795                 800 
Ala Ile Asp Asp Tyr Asp Ser Ser Gly Ala Ser Lys Asp Glu Ile Lys
                805                 810                 815     
Glu Arg Phe Ala Gln Thr Met Glu Phe Val Glu Glu Tyr Leu Arg Asp
            820                 825                 830         
Val Val Cys Gln Arg Phe Pro Phe Ser Asp Lys Glu Lys Asn Lys Leu
        835                 840                 845             
Thr Phe Glu Val Val Asn Leu Ala Arg Asn Leu Ile Tyr Phe Gly Phe
    850                 855                 860                 
Tyr Asn Phe Ser Asp Leu Leu Arg Leu Thr Lys Ile Leu Leu Ala Ile
865                 870                 875                 880 
Leu Asp Cys Val His Val Thr Thr Ile Phe Pro Ile Ser Lys Met Ala
                885                 890                 895     
Lys Gly Glu Glu Asn Lys Gly Ser Asn Val Met Arg Ser Ile His Gly
            900                 905                 910         
Val Gly Glu Leu Met Thr Gln Val Val Leu Arg Gly Gly Gly Phe Leu
        915                 920                 925             
Pro Met Thr Pro Met Ala Ala Ala Pro Glu Gly Asn Val Lys Gln Ala
    930                 935                 940                 
Glu Pro Glu Lys Glu Asp Ile Met Val Met Asp Thr Lys Leu Lys Ile
945                 950                 955                 960 
Ile Glu Ile Leu Gln Phe Ile Leu Asn Val Arg Leu Asp Tyr Arg Ile
                965                 970                 975     
Ser Cys Leu Leu Cys Ile Phe Lys Arg Glu Phe Asp Glu Ser Asn Ser
            980                 985                 990         
Gln Thr Ser Glu Thr Ser Ser Gly Asn Ser Ser Gln Glu Gly Pro Ser
        995                 1000                1005            
Asn Val Pro Gly Ala Leu Asp Phe Glu His Ile Glu Glu Gln Ala Glu
    1010                1015                1020                
Gly Ile Phe Gly Gly Ser Glu Glu Asn Thr Pro Leu Asp Leu Asp Asp
1025                1030                1035                1040
His Gly Gly Arg Thr Phe Leu Arg Val Leu Leu His Leu Thr Met His
                1045                1050                1055    
Asp Tyr Pro Pro Leu Val Ser Gly Ala Leu Gln Leu Leu Phe Arg His
            1060                1065                1070        
Phe Ser Gln Arg Gln Glu Val Leu Gln Ala Phe Lys Gln Val Gln Leu
        1075                1080                1085            
Leu Val Thr Ser Gln Asp Val Asp Asn Tyr Lys Gln Ile Lys Gln Asp
    1090                1095                1100                
Leu Asp Gln Leu Arg Ser Ile Val Glu Lys Ser Glu Leu Trp Val Tyr
1105                1110                1115                1120
Lys Gly Gln Gly Pro Asp Glu Thr Met Asp Gly Ala Ser Gly Glu Asn
                1125                1130                1135    
Glu His Lys Lys Thr Glu Glu Gly Asn Asn Lys Pro Gln Lys His Glu
            1140                1145                1150        
Ser Thr Ser Ser Tyr Asn Tyr Arg Val Val Lys Glu Ile Leu Ile Arg
        1155                1160                1165            
Leu Ser Lys Leu Cys Val Gln Glu Ser Ala Ser Val Arg Lys Ser Arg
    1170                1175                1180                
Lys Gln Gln Gln Arg Leu Leu Arg Asn Met Gly Ala His Ala Val Val
1185                1190                1195                1200
Leu Glu Leu Leu Gln Ile Pro Tyr Glu Lys Ala Glu Asp Thr Lys Met
                1205                1210                1215    
Gln Glu Ile Met Arg Leu Ala His Glu Phe Leu Gln Asn Phe Cys Ala
            1220                1225                1230        
Gly Asn Gln Gln Asn Gln Ala Leu Leu His Lys His Ile Asn Leu Phe
        1235                1240                1245            
Leu Asn Pro Gly Ile Leu Glu Ala Val Thr Met Gln His Ile Phe Met
    1250                1255                1260                
Asn Asn Phe Gln Leu Cys Ser Glu Ile Asn Glu Arg Val Val Gln His
1265                1270                1275                1280
Phe Val His Cys Ile Glu Thr His Gly Arg Asn Val Gln Tyr Ile Lys
                1285                1290                1295    
Phe Leu Gln Thr Ile Val Lys Ala Glu Gly Lys Phe Ile Lys Lys Cys
            1300                1305                1310        
Gln Asp Met Val Met Ala Glu Leu Val Asn Ser Gly Glu Asp Val Leu
        1315                1320                1325            
Val Phe Tyr Asn Asp Arg Ala Ser Phe Gln Thr Leu Ile Gln Met Met
    1330                1335                1340                
Arg Ser Glu Arg Asp Arg Met Asp Glu Asn Ser Pro Leu Met Tyr His
1345                1350                1355                1360
Ile His Leu Val Glu Leu Leu Ala Val Cys Thr Glu Gly Lys Asn Val
                1365                1370                1375    
Tyr Thr Glu Ile Lys Cys Asn Ser Leu Leu Pro Leu Asp Asp Ile Val
            1380                1385                1390        
Arg Val Val Thr His Glu Asp Cys Ile Pro Glu Val Lys Ile Ala Tyr
        1395                1400                1405            
Ile Asn Phe Leu Asn His Cys Tyr Val Asp Thr Glu Val Glu Met Lys
    1410                1415                1420                
Glu Ile Tyr Thr Ser Asn His Met Trp Lys Leu Phe Glu Asn Phe Leu
1425                1430                1435                1440
Val Asp Ile Cys Arg Ala Cys Asn Asn Thr Ser Asp Arg Lys His Ala
                1445                1450                1455    
Asp Ser Ile Leu Glu Lys Tyr Val Thr Glu Ile Val Met Ser Ile Val
            1460                1465                1470        
Thr Thr Phe Phe Ser Ser Pro Phe Ser Asp Gln Ser Thr Thr Leu Gln
        1475                1480                1485            
Thr Arg Gln Pro Val Phe Val Gln Leu Leu Gln Gly Val Phe Arg Val
    1490                1495                1500                
Tyr His Cys Asn Trp Leu Met Pro Ser Gln Lys Ala Ser Val Glu Ser
1505                1510                1515                1520
Cys Ile Arg Val Leu Ser Asp Val Ala Lys Ser Arg Ala Ile Ala Ile
                1525                1530                1535    
Pro Val Asp Leu Asp Ser Gln Val Asn Asn Leu Phe Leu Lys Ser His
            1540                1545                1550        
Ser Ile Val Gln Lys Thr Ala Met Asn Trp Arg Leu Ser Ala Arg Asn
        1555                1560                1565            
Ala Ala Arg Arg Asp Ser Val Leu Ala Ala Ser Arg Asp Tyr Arg Asn
    1570                1575                1580                
Ile Ile Glu Arg Leu Gln Asp Ile Val Ser Ala Leu Glu Asp Arg Leu
1585                1590                1595                1600
Arg Pro Leu Val Gln Ala Glu Leu Ser Val Leu Val Asp Val Leu His
                1605                1610                1615    
Arg Pro Glu Leu Leu Phe Pro Glu Asn Thr Asp Ala Arg Arg Lys Cys
            1620                1625                1630        
Glu Ser Gly Gly Phe Ile Cys Lys Leu Ile Lys His Thr Lys Gln Leu
        1635                1640                1645            
Leu Glu Glu Asn Glu Glu Lys Leu Cys Ile Lys Val Leu Gln Thr Leu
    1650                1655                1660                
Arg Glu Met Met Thr Lys Asp Arg Gly Tyr Gly Glu Lys Gly Glu Ala
1665                1670                1675                1680
Leu Arg Gln Val Leu Val Asn Arg Tyr Tyr Gly Asn Val Arg Pro Ser
                1685                1690                1695    
Gly Arg Arg Glu Ser Leu Thr Ser Phe Gly Asn Gly Pro Leu Ser Ala
            1700                1705                1710        
Gly Gly Pro Gly Lys Pro Gly Gly Gly Gly Gly Gly Ser Gly Ser Ser
        1715                1720                1725            
Ser Met Ser Arg Gly Glu Met Ser Leu Ala Glu Val Gln Cys His Leu
    1730                1735                1740                
Asp Lys Glu Gly Ala Ser Asn Leu Val Ile Asp Leu Ile Met Asn Ala
1745                1750                1755                1760
Ser Ser Asp Arg Val Phe His Glu Ser Ile Leu Leu Ala Ile Ala Leu
                1765                1770                1775    
Leu Glu Gly Gly Asn Thr Thr Ile Gln His Ser Phe Phe Cys Arg Leu
            1780                1785                1790        
Thr Glu Asp Lys Lys Ser Glu Lys Phe Phe Lys Val Phe Tyr Asp Arg
        1795                1800                1805            
Met Lys Val Ala Gln Gln Glu Ile Lys Ala Thr Val Thr Val Asn Thr
    1810                1815                1820                
Ser Asp Leu Gly Asn Lys Lys Lys Asp Asp Glu Val Asp Arg Asp Ala
1825                1830                1835                1840
Pro Ser Arg Lys Lys Ala Lys Glu Pro Thr Thr Gln Ile Thr Glu Glu
                1845                1850                1855    
Val Arg Asp Gln Leu Leu Glu Ala Ser Ala Ala Thr Arg Lys Ala Phe
            1860                1865                1870        
Thr Thr Phe Arg Arg Glu Ala Asp Pro Asp Asp His Tyr Gln Pro Gly
        1875                1880                1885            
Glu Gly Thr Gln Ala Thr Ala Asp Lys Ala Lys Asp Asp Leu Glu Met
    1890                1895                1900                
Ser Ala Val Ile Thr Ile Met Gln Pro Ile Leu Arg Phe Leu Gln Leu
1905                1910                1915                1920
Leu Cys Glu Asn His Asn Arg Asp Leu Gln Asn Phe Leu Arg Cys Gln
                1925                1930                1935    
Asn Asn Lys Thr Asn Tyr Asn Leu Val Cys Glu Thr Leu Gln Phe Leu
            1940                1945                1950        
Asp Cys Ile Cys Gly Ser Thr Thr Gly Gly Leu Gly Leu Leu Gly Leu
        1955                1960                1965            
Tyr Ile Asn Glu Lys Asn Val Ala Leu Ile Asn Gln Thr Leu Glu Ser
    1970                1975                1980                
Leu Thr Glu Tyr Cys Gln Gly Pro Cys His Glu Asn Gln Asn Cys Ile
1985                1990                1995                2000
Ala Thr His Glu Ser Asn Gly Ile Asp Ile Ile Thr Ala Leu Ile Leu
                2005                2010                2015    
Asn Asp Ile Asn Pro Leu Gly Lys Lys Arg Met Asp Leu Val Leu Glu
            2020                2025                2030        
Leu Lys Asn Asn Ala Ser Lys Leu Leu Leu Ala Ile Met Glu Ser Arg
        2035                2040                2045            
His Asp Ser Glu Asn Ala Glu Arg Ile Leu Tyr Asn Met Arg Pro Lys
    2050                2055                2060                
Glu Leu Val Glu Val Ile Lys Lys Ala Tyr Met Gln Gly Glu Val Glu
2065                2070                2075                2080
Phe Glu Asp Gly Glu Asn Gly Glu Asp Gly Ala Ala Ser Pro Arg Asn
                2085                2090                2095    
Val Gly His Asn Ile Tyr Ile Leu Ala His Gln Leu Ala Arg His Asn
            2100                2105                2110        
Lys Glu Leu Gln Ser Met Leu Lys Pro Gly Gly Gln Val Asp Gly Asp
        2115                2120                2125            
Glu Ala Leu Glu Phe Tyr Ala Lys His Thr Ala Gln Ile Glu Ile Val
    2130                2135                2140                
Arg Leu Asp Arg Thr Met Glu Gln Ile Val Phe Pro Val Pro Ser Ile
2145                2150                2155                2160
Cys Glu Phe Leu Thr Lys Glu Ser Lys Leu Arg Ile Tyr Tyr Thr Thr
                2165                2170                2175    
Glu Arg Asp Glu Gln Gly Ser Lys Ile Asn Asp Phe Phe Leu Arg Ser
            2180                2185                2190        
Glu Asp Leu Phe Asn Glu Met Asn Trp Gln Lys Lys Leu Arg Ala Gln
        2195                2200                2205            
Pro Val Leu Tyr Trp Cys Ala Arg Asn Met Ser Phe Trp Ser Ser Ile
    2210                2215                2220                
Ser Phe Asn Leu Ala Val Leu Met Asn Leu Leu Val Ala Phe Phe Tyr
2225                2230                2235                2240
Pro Phe Lys Gly Val Arg Gly Gly Thr Leu Glu Pro His Trp Ser Gly
                2245                2250                2255    
Leu Leu Trp Thr Ala Met Leu Ile Ser Leu Ala Ile Val Ile Ala Leu
            2260                2265                2270        
Pro Lys Pro His Gly Ile Arg Ala Leu Ile Ala Ser Thr Ile Leu Arg
        2275                2280                2285            
Leu Ile Phe Ser Val Gly Leu Gln Pro Thr Leu Phe Leu Leu Gly Ala
    2290                2295                2300                
Phe Asn Val Cys Asn Lys Ile Ile Phe Leu Met Ser Phe Val Gly Asn
2305                2310                2315                2320
Cys Gly Thr Phe Thr Arg Gly Tyr Arg Ala Met Val Leu Asp Val Glu
                2325                2330                2335    
Phe Leu Tyr His Leu Leu Tyr Leu Val Ile Cys Ala Met Gly Leu Phe
            2340                2345                2350        
Val His Glu Phe Phe Tyr Ser Leu Leu Leu Phe Asp Leu Val Tyr Arg
        2355                2360                2365            
Glu Glu Thr Leu Leu Asn Val Ile Lys Ser Val Thr Arg Asn Gly Arg
    2370                2375                2380                
Ser Ile Ile Leu Thr Ala Val Leu Ala Leu Ile Leu Val Tyr Leu Phe
2385                2390                2395                2400
Ser Ile Val Gly Tyr Leu Phe Phe Lys Asp Asp Phe Ile Leu Glu Val
                2405                2410                2415    
Asp Arg Leu Pro Asn Glu Thr Ala Val Pro Glu Thr Gly Glu Ser Leu
            2420                2425                2430        
Ala Ser Glu Phe Leu Phe Ser Asp Val Cys Arg Val Glu Ser Gly Glu
        2435                2440                2445            
Asn Cys Ser Ser Pro Ala Pro Arg Glu Glu Leu Val Pro Ala Glu Glu
    2450                2455                2460                
Thr Glu Gln Asp Lys Glu His Thr Cys Glu Thr Leu Leu Met Cys Ile
2465                2470                2475                2480
Val Thr Val Leu Ser His Gly Leu Arg Ser Gly Gly Gly Val Gly Asp
                2485                2490                2495    
Val Leu Arg Lys Pro Ser Lys Glu Glu Pro Leu Phe Ala Ala Arg Val
            2500                2505                2510        
Ile Tyr Asp Leu Leu Phe Phe Phe Met Val Ile Ile Ile Val Leu Asn
        2515                2520                2525            
Leu Ile Phe Gly Val Ile Ile Asp Thr Phe Ala Asp Leu Arg Ser Glu
    2530                2535                2540                
Lys Gln Lys Lys Glu Glu Ile Leu Lys Thr Thr Cys Phe Ile Cys Gly
2545                2550                2555                2560
Leu Glu Arg Asp Lys Phe Asp Asn Lys Thr Val Thr Phe Glu Glu His
                2565                2570                2575    
Ile Lys Glu Glu His Asn Met Trp His Tyr Leu Cys Phe Ile Val Leu
            2580                2585                2590        
Val Lys Val Lys Asp Ser Thr Glu Tyr Thr Gly Pro Glu Ser Tyr Val
        2595                2600                2605            
Ala Glu Met Ile Lys Glu Arg Asn Leu Asp Trp Phe Pro Arg Met Arg
    2610                2615                2620                
Ala Met Ser Leu Val Ser Ser Asp Ser Glu Gly Glu Gln Asn Glu Leu
2625                2630                2635                2640
Arg Asn Leu Gln Glu Lys Leu Glu Ser Thr Met Lys Leu Val Thr Asn
                2645                2650                2655    
Leu Ser Gly Gln Leu Ser Glu Leu Lys Asp Gln Met Thr Glu Gln Arg
            2660                2665                2670        
Lys Gln Lys Gln Arg Ile Gly Leu Leu Gly His Pro Pro His Met Asn
        2675                2680                2685            
Val Asn Pro Gln Gln Pro Ala
    2690                2695


<210> 1109
<211> 249
<212> PRT
<213> Homo sapiens

<400> 1109
Met Phe Phe Ser Ala Ala Leu Arg Ala Arg Ala Ala Gly Leu Thr Ala
 1               5                  10                  15      
His Trp Gly Arg His Val Arg Asn Leu His Lys Thr Ala Met Gln Asn
            20                  25                  30          
Gly Ala Gly Gly Ala Leu Phe Val His Arg Asp Thr Pro Glu Asn Asn
        35                  40                  45              
Pro Asp Thr Pro Phe Asp Phe Thr Pro Glu Asn Tyr Lys Arg Ile Glu
    50                  55                  60                  
Ala Ile Val Lys Asn Tyr Pro Glu Gly His Lys Ala Ala Ala Val Leu
65                  70                  75                  80  
Pro Val Leu Asp Leu Ala Gln Arg Gln Asn Gly Trp Leu Pro Ile Ser
                85                  90                  95      
Ala Met Asn Lys Val Ala Glu Val Leu Gln Val Pro Pro Met Arg Val
            100                 105                 110         
Tyr Glu Val Ala Thr Phe Tyr Thr Met Tyr Asn Arg Lys Pro Val Gly
        115                 120                 125             
Lys Tyr His Ile Gln Val Cys Thr Thr Thr Pro Cys Met Leu Arg Asn
    130                 135                 140                 
Ser Asp Ser Ile Leu Glu Ala Ile Gln Lys Lys Leu Gly Ile Lys Val
145                 150                 155                 160 
Gly Glu Thr Thr Pro Asp Lys Leu Phe Thr Leu Ile Glu Val Glu Cys
                165                 170                 175     
Leu Gly Ala Cys Val Asn Ala Pro Met Val Gln Ile Asn Asp Asn Tyr
            180                 185                 190         
Tyr Glu Asp Leu Thr Ala Lys Asp Ile Glu Glu Ile Ile Asp Glu Leu
        195                 200                 205             
Lys Ala Gly Lys Ile Pro Lys Pro Gly Pro Arg Ser Gly Arg Phe Ser
    210                 215                 220                 
Cys Glu Pro Ala Gly Gly Leu Thr Ser Leu Thr Glu Pro Pro Lys Gly
225                 230                 235                 240 
Pro Gly Phe Gly Val Gln Ala Gly Leu
                245                 


<210> 1110
<211> 518
<212> PRT
<213> Homo sapiens

<400> 1110
Met Thr Ser Ser Lys Ile Glu Met Pro Gly Glu Val Lys Ala Asp Pro
 1               5                  10                  15      
Ala Ala Leu Met Ala Ser Leu His Leu Leu Pro Ser Pro Thr Pro Asn
            20                  25                  30          
Leu Glu Ile Lys Tyr Thr Lys Ile Phe Ile Asn Asn Glu Trp Gln Asn
        35                  40                  45              
Ser Glu Ser Gly Arg Val Phe Pro Val Tyr Asn Pro Ala Thr Gly Glu
    50                  55                  60                  
Gln Val Cys Glu Val Gln Glu Ala Asp Lys Ala Asp Ile Asp Lys Ala
65                  70                  75                  80  
Val Gln Ala Ala Arg Leu Ala Phe Ser Leu Gly Ser Val Trp Arg Arg
                85                  90                  95      
Met Asp Ala Ser Glu Arg Gly Arg Leu Leu Asp Lys Leu Ala Asp Leu
            100                 105                 110         
Val Glu Arg Asp Arg Ala Val Leu Ala Thr Met Glu Ser Leu Asn Gly
        115                 120                 125             
Gly Lys Pro Phe Leu Gln Ala Phe Tyr Val Asp Leu Gln Gly Val Ile
    130                 135                 140                 
Lys Thr Phe Arg Tyr Tyr Ala Gly Trp Ala Asp Lys Ile His Gly Met
145                 150                 155                 160 
Thr Ile Pro Val Asp Gly Asp Tyr Phe Thr Phe Thr Arg His Glu Pro
                165                 170                 175     
Ile Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Leu Met
            180                 185                 190         
Phe Ala Trp Lys Ile Ala Pro Ala Leu Cys Cys Gly Asn Thr Val Val
        195                 200                 205             
Ile Lys Pro Ala Glu Gln Thr Pro Leu Ser Ala Leu Tyr Met Gly Ala
    210                 215                 220                 
Leu Ile Lys Glu Ala Gly Phe Pro Pro Gly Val Ile Asn Ile Leu Pro
225                 230                 235                 240 
Gly Tyr Gly Pro Thr Ala Gly Ala Ala Ile Ala Ser His Ile Gly Ile
                245                 250                 255     
Asp Lys Ile Ala Phe Thr Gly Ser Thr Glu Val Gly Lys Leu Ile Gln
            260                 265                 270         
Glu Ala Ala Gly Arg Ser Asn Leu Lys Arg Val Thr Leu Glu Leu Gly
        275                 280                 285             
Gly Lys Ser Pro Asn Ile Ile Phe Ala Asp Ala Asp Leu Asp Tyr Ala
    290                 295                 300                 
Val Glu Gln Ala His Gln Gly Val Phe Phe Asn Gln Gly Gln Cys Cys
305                 310                 315                 320 
Thr Ala Gly Ser Arg Ile Phe Val Glu Glu Ser Ile Tyr Glu Glu Phe
                325                 330                 335     
Val Arg Arg Ser Val Glu Arg Ala Lys Arg Arg Ile Val Gly Ser Pro
            340                 345                 350         
Phe Asp Pro Thr Thr Glu Gln Gly Pro Gln Ile Asp Lys Lys Gln Tyr
        355                 360                 365             
Asn Lys Ile Leu Glu Leu Ile Gln Ser Gly Val Ala Glu Gly Ala Lys
    370                 375                 380                 
Leu Glu Cys Gly Gly Lys Gly Leu Gly Arg Lys Gly Phe Phe Ile Glu
385                 390                 395                 400 
Pro Thr Val Phe Ser Asn Val Thr Asp Asp Met Arg Ile Ala Lys Glu
                405                 410                 415     
Glu Ile Phe Gly Pro Val Gln Glu Ile Leu Arg Phe Lys Thr Met Asp
            420                 425                 430         
Glu Val Ile Glu Arg Ala Asn Asn Ser Asp Phe Gly Leu Val Ala Ala
        435                 440                 445             
Val Phe Thr Asn Asp Ile Asn Lys Ala Leu Thr Val Ser Ser Ala Met
    450                 455                 460                 
Gln Ala Gly Thr Val Trp Ile Asn Cys Tyr Asn Ala Leu Asn Ala Gln
465                 470                 475                 480 
Ser Pro Phe Gly Gly Phe Lys Met Ser Gly Asn Gly Arg Glu Met Gly
                485                 490                 495     
Glu Phe Gly Leu Arg Glu Tyr Ser Glu Val Lys Thr Val Thr Val Lys
            500                 505                 510         
Ile Pro Gln Lys Asn Ser
        515             


<210> 1111
<211> 235
<212> PRT
<213> Homo sapiens

<400> 1111
Met Asn Ile Arg Asn Ala Arg Pro Glu Asp Leu Met Asn Met Gln His
 1               5                  10                  15      
Cys Asn Leu Leu Cys Leu Pro Glu Asn Tyr Gln Met Lys Tyr Tyr Phe
            20                  25                  30          
Tyr His Gly Leu Ser Trp Pro Gln Leu Ser Tyr Ile Ala Glu Asp Glu
        35                  40                  45              
Asn Gly Lys Ile Val Gly Tyr Val Leu Ala Lys Met Glu Glu Asp Pro
    50                  55                  60                  
Asp Asp Val Pro His Gly His Ile Thr Ser Leu Ala Val Lys Arg Ser
65                  70                  75                  80  
His Arg Arg Leu Gly Leu Ala Gln Lys Leu Met Asp Gln Ala Ser Arg
                85                  90                  95      
Ala Met Ile Glu Asn Phe Asn Ala Lys Tyr Val Ser Leu His Val Arg
            100                 105                 110         
Lys Ser Asn Arg Ala Ala Leu His Leu Tyr Ser Asn Thr Leu Asn Phe
        115                 120                 125             
Gln Ile Ser Glu Val Glu Pro Lys Tyr Tyr Ala Asp Gly Glu Asp Ala
    130                 135                 140                 
Tyr Ala Met Lys Arg Asp Leu Thr Gln Met Ala Asp Glu Leu Arg Arg
145                 150                 155                 160 
His Leu Glu Leu Lys Glu Lys Gly Arg His Val Val Leu Gly Ala Ile
                165                 170                 175     
Glu Asn Lys Val Glu Ser Lys Gly Asn Ser Pro Pro Ser Ser Gly Glu
            180                 185                 190         
Ala Cys Arg Glu Glu Lys Gly Leu Ala Ala Glu Asp Ser Gly Gly Asp
        195                 200                 205             
Ser Lys Asp Leu Ser Glu Val Ser Glu Thr Thr Glu Ser Thr Asp Val
    210                 215                 220                 
Lys Asp Ser Ser Glu Ala Ser Asp Ser Ala Ser
225                 230                 235 


<210> 1112
<211> 437
<212> PRT
<213> Homo sapiens

<400> 1112
Met Ala Ser Pro Ser Ser Phe Thr Tyr Tyr Cys Pro Pro Ser Ser Ser
 1               5                  10                  15      
Pro Val Trp Ser Glu Pro Leu Tyr Ser Leu Arg Pro Glu His Ala Arg
            20                  25                  30          
Glu Arg Leu Gln Asp Asp Ser Val Glu Thr Val Thr Ser Ile Glu Gln
        35                  40                  45              
Ala Lys Val Glu Glu Lys Ile Gln Glu Val Phe Ser Ser Tyr Lys Phe
    50                  55                  60                  
Asn His Leu Val Pro Arg Leu Val Leu Gln Arg Glu Lys His Phe His
65                  70                  75                  80  
Tyr Leu Lys Arg Gly Leu Arg Gln Leu Thr Asp Ala Tyr Glu Cys Leu
                85                  90                  95      
Asp Ala Ser Arg Pro Trp Leu Cys Tyr Trp Ile Leu His Ser Leu Glu
            100                 105                 110         
Leu Leu Asp Glu Pro Ile Pro Gln Ile Val Ala Thr Asp Val Cys Gln
        115                 120                 125             
Phe Leu Glu Leu Cys Gln Ser Pro Glu Gly Gly Phe Gly Gly Gly Pro
    130                 135                 140                 
Gly Gln Tyr Pro His Leu Ala Pro Thr Tyr Ala Ala Val Asn Ala Leu
145                 150                 155                 160 
Cys Ile Ile Gly Thr Glu Glu Ala Tyr Asp Ile Ile Asn Arg Glu Lys
                165                 170                 175     
Leu Leu Gln Tyr Leu Tyr Ser Leu Lys Gln Pro Asp Gly Ser Phe Leu
            180                 185                 190         
Met His Val Gly Gly Glu Val Asp Val Arg Ser Ala Tyr Cys Ala Ala
        195                 200                 205             
Ser Val Ala Ser Leu Thr Asn Ile Ile Thr Pro Asp Leu Phe Glu Gly
    210                 215                 220                 
Thr Ala Glu Trp Ile Ala Arg Cys Gln Asn Trp Glu Gly Gly Ile Gly
225                 230                 235                 240 
Gly Val Pro Gly Met Glu Ala His Gly Gly Tyr Thr Phe Cys Gly Leu
                245                 250                 255     
Ala Ala Leu Val Ile Leu Lys Arg Glu Arg Ser Leu Asn Leu Lys Ser
            260                 265                 270         
Leu Leu Gln Trp Val Thr Ser Arg Gln Met Arg Phe Glu Gly Gly Phe
        275                 280                 285             
Gln Gly Arg Cys Asn Lys Leu Val Asp Gly Cys Tyr Ser Phe Trp Gln
    290                 295                 300                 
Ala Gly Leu Leu Pro Leu Leu His Arg Ala Leu His Ala Gln Gly Asp
305                 310                 315                 320 
Pro Ala Leu Ser Met Ser His Trp Met Phe His Gln Gln Ala Leu Gln
                325                 330                 335     
Glu Tyr Ile Leu Met Cys Cys Gln Cys Pro Ala Gly Gly Leu Leu Asp
            340                 345                 350         
Lys Pro Gly Lys Ser Arg Asp Phe Tyr His Thr Cys Tyr Cys Leu Ser
        355                 360                 365             
Gly Leu Ser Ile Ala Gln His Phe Gly Ser Gly Ala Met Leu His Asp
    370                 375                 380                 
Val Val Leu Gly Val Pro Glu Asn Ala Leu Gln Pro Thr His Pro Val
385                 390                 395                 400 
Tyr Asn Ile Gly Pro Asp Lys Val Ile Gln Ala Thr Thr Tyr Phe Leu
                405                 410                 415     
Gln Lys Pro Val Pro Gly Phe Glu Glu Leu Lys Asp Glu Thr Ser Ala
            420                 425                 430         
Glu Pro Ala Thr Asp
        435         


<210> 1113
<211> 294
<212> PRT
<213> Homo sapiens

<400> 1113
Met Glu Asp Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn
 1               5                  10                  15      
Tyr Leu Phe Gly Cys Glu Leu Lys Ala Asp Lys Asp Tyr His Phe Lys
            20                  25                  30          
Val Asp Asn Asp Glu Asn Glu His Gln Leu Ser Leu Arg Thr Val Ser
        35                  40                  45              
Leu Gly Ala Gly Ala Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala
    50                  55                  60                  
Met Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys
65                  70                  75                  80  
Met Ser Val Gln Pro Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro
                85                  90                  95      
Pro Val Val Leu Arg Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser
            100                 105                 110         
Gly Gln His Leu Val Ala Val Glu Glu Asp Ala Glu Ser Glu Asp Glu
        115                 120                 125             
Glu Glu Glu Asp Val Lys Leu Leu Ser Ile Ser Gly Lys Arg Ser Ala
    130                 135                 140                 
Pro Gly Gly Gly Ser Lys Val Pro Gln Lys Lys Val Lys Leu Ala Ala
145                 150                 155                 160 
Asp Glu Asp Asp Asp Asp Asp Asp Glu Glu Asp Asp Asp Glu Asp Asp
                165                 170                 175     
Asp Asp Asp Asp Phe Asp Asp Glu Glu Ala Glu Glu Lys Ala Pro Val
            180                 185                 190         
Lys Lys Ser Ile Arg Asp Thr Pro Ala Lys Asn Ala Gln Lys Ser Asn
        195                 200                 205             
Gln Asn Gly Lys Asp Ser Lys Pro Ser Ser Thr Pro Arg Ser Lys Gly
    210                 215                 220                 
Gln Glu Ser Phe Lys Lys Gln Glu Lys Thr Pro Lys Thr Pro Lys Gly
225                 230                 235                 240 
Pro Ser Ser Val Glu Asp Ile Lys Ala Lys Met Gln Ala Ser Ile Glu
                245                 250                 255     
Lys Gly Gly Ser Leu Pro Lys Val Glu Ala Lys Phe Ile Asn Tyr Val
            260                 265                 270         
Lys Asn Cys Phe Arg Met Thr Asp Gln Glu Ala Ile Gln Asp Leu Trp
        275                 280                 285             
Gln Trp Arg Lys Ser Leu
    290                 


<210> 1114
<211> 108
<212> PRT
<213> Homo sapiens

<400> 1114
Met Ala Ala Pro Cys Leu Leu Arg Lys Gly Arg Ala Gly Ala Leu Lys
 1               5                  10                  15      
Thr Met Leu Gln Glu Ala Gln Val Phe Arg Gly Leu Ala Ser Thr Val
            20                  25                  30          
Ser Leu Ser Ala Glu Ser Gly Lys Ser Glu Lys Gly Gln Pro Gln Asn
        35                  40                  45              
Ser Lys Lys Gln Ser Pro Pro Lys Lys Pro Ala Pro Val Pro Ala Glu
    50                  55                  60                  
Pro Phe Asp Asn Thr Thr Tyr Lys Asn Leu Gln His His Asp Tyr Ser
65                  70                  75                  80  
Thr Tyr Thr Phe Leu Asp Leu Asn Leu Glu Leu Ser Lys Phe Arg Met
                85                  90                  95      
Pro Gln Pro Ser Ser Gly Arg Glu Ser Pro Arg His
            100                 105             


<210> 1115
<211> 1026
<212> PRT
<213> Homo sapiens

<400> 1115
Met Met Ser Phe Gly Gly Ala Asp Ala Leu Leu Gly Ala Pro Phe Ala
 1               5                  10                  15      
Pro Leu His Gly Gly Gly Ser Leu His Tyr Ala Leu Ala Arg Lys Gly
            20                  25                  30          
Gly Ala Gly Gly Thr Arg Ser Ala Ala Gly Ser Ser Ser Gly Phe His
        35                  40                  45              
Ser Trp Thr Arg Thr Ser Val Ser Ser Val Ser Ala Ser Pro Ser Arg
    50                  55                  60                  
Phe Arg Gly Ala Gly Ala Ala Ser Ser Thr Asp Ser Leu Asp Thr Leu
65                  70                  75                  80  
Ser Asn Gly Pro Glu Gly Cys Met Val Ala Val Ala Thr Ser Arg Ser
                85                  90                  95      
Glu Lys Glu Gln Leu Gln Ala Leu Asn Asp Arg Phe Ala Gly Tyr Ile
            100                 105                 110         
Asp Lys Val Arg Gln Leu Glu Ala His Asn Arg Ser Leu Glu Gly Glu
        115                 120                 125             
Ala Ala Ala Leu Arg Gln Gln Gln Ala Gly Arg Ser Ala Met Gly Glu
    130                 135                 140                 
Leu Tyr Glu Arg Glu Val Arg Glu Met Arg Gly Ala Val Leu Arg Leu
145                 150                 155                 160 
Gly Ala Ala Arg Gly Gln Leu Arg Leu Glu Gln Glu His Leu Leu Glu
                165                 170                 175     
Asp Ile Ala His Val Arg Gln Arg Leu Asp Asp Glu Ala Arg Gln Arg
            180                 185                 190         
Glu Glu Ala Glu Ala Ala Ala Arg Ala Leu Ala Arg Phe Ala Gln Glu
        195                 200                 205             
Ala Glu Ala Ala Arg Val Asp Leu Gln Lys Lys Ala Gln Ala Leu Gln
    210                 215                 220                 
Glu Glu Cys Gly Tyr Leu Arg Arg His His Gln Glu Glu Val Gly Glu
225                 230                 235                 240 
Leu Leu Gly Gln Ile Gln Gly Ser Gly Ala Ala Gln Ala Gln Met Gln
                245                 250                 255     
Ala Glu Thr Arg Asp Ala Leu Lys Cys Asp Val Thr Ser Ala Leu Arg
            260                 265                 270         
Glu Ile Arg Ala Gln Leu Glu Gly His Ala Val Gln Ser Thr Leu Gln
        275                 280                 285             
Ser Glu Glu Trp Phe Arg Val Arg Leu Asp Arg Leu Ser Glu Ala Ala
    290                 295                 300                 
Lys Val Asn Thr Asp Ala Met Arg Ser Ala Gln Glu Glu Ile Thr Glu
305                 310                 315                 320 
Tyr Arg Arg Gln Leu Gln Ala Arg Thr Thr Glu Leu Glu Ala Leu Lys
                325                 330                 335     
Ser Thr Lys Asp Ser Leu Glu Arg Gln Arg Ser Glu Leu Glu Asp Arg
            340                 345                 350         
His Gln Ala Asp Ile Ala Ser Tyr Gln Glu Ala Ile Gln Gln Leu Asp
        355                 360                 365             
Ala Glu Leu Arg Asn Thr Lys Trp Glu Met Ala Ala Gln Leu Arg Glu
    370                 375                 380                 
Tyr Gln Asp Leu Leu Asn Val Lys Met Ala Leu Asp Ile Glu Ile Ala
385                 390                 395                 400 
Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu Cys Arg Ile Gly Phe Gly
                405                 410                 415     
Pro Ile Pro Phe Ser Leu Pro Glu Gly Leu Pro Lys Ile Pro Ser Val
            420                 425                 430         
Ser Thr His Ile Lys Val Lys Ser Glu Glu Lys Ile Lys Val Val Glu
        435                 440                 445             
Lys Ser Glu Lys Glu Thr Val Ile Val Glu Glu Gln Thr Glu Glu Thr
    450                 455                 460                 
Gln Val Thr Glu Glu Val Thr Glu Glu Glu Glu Lys Glu Ala Lys Glu
465                 470                 475                 480 
Glu Glu Gly Lys Glu Glu Glu Gly Gly Glu Glu Glu Glu Ala Glu Gly
                485                 490                 495     
Gly Glu Glu Glu Thr Lys Ser Pro Pro Ala Glu Glu Ala Ala Ser Pro
            500                 505                 510         
Glu Lys Glu Ala Lys Ser Pro Val Lys Glu Glu Ala Lys Ser Pro Ala
        515                 520                 525             
Glu Ala Lys Ser Pro Glu Lys Glu Glu Ala Lys Ser Pro Ala Glu Val
    530                 535                 540                 
Lys Ser Pro Glu Lys Ala Lys Ser Pro Ala Lys Glu Glu Ala Lys Ser
545                 550                 555                 560 
Pro Pro Glu Ala Lys Ser Pro Glu Lys Glu Glu Ala Lys Ser Pro Ala
                565                 570                 575     
Glu Val Lys Ser Pro Glu Lys Ala Lys Ser Pro Ala Lys Glu Glu Ala
            580                 585                 590         
Lys Ser Pro Ala Glu Ala Lys Ser Pro Glu Lys Ala Lys Ser Pro Val
        595                 600                 605             
Lys Glu Glu Ala Lys Ser Pro Ala Glu Ala Lys Ser Pro Val Lys Glu
    610                 615                 620                 
Glu Ala Lys Ser Pro Ala Glu Val Lys Ser Pro Glu Lys Ala Lys Ser
625                 630                 635                 640 
Pro Thr Lys Glu Glu Ala Lys Ser Pro Glu Lys Ala Lys Ser Pro Glu
                645                 650                 655     
Lys Ala Lys Ser Pro Glu Lys Glu Glu Ala Lys Ser Pro Glu Lys Ala
            660                 665                 670         
Lys Ser Pro Val Lys Ala Glu Ala Lys Ser Pro Glu Lys Ala Lys Ser
        675                 680                 685             
Pro Val Lys Ala Glu Ala Lys Ser Pro Glu Lys Ala Lys Ser Pro Val
    690                 695                 700                 
Lys Glu Glu Ala Lys Ser Pro Glu Lys Ala Lys Ser Pro Val Lys Glu
705                 710                 715                 720 
Glu Ala Lys Ser Pro Glu Lys Ala Lys Ser Pro Val Lys Glu Glu Ala
                725                 730                 735     
Lys Thr Pro Glu Lys Ala Lys Ser Pro Val Lys Glu Glu Ala Lys Ser
            740                 745                 750         
Pro Glu Lys Ala Lys Ser Pro Glu Lys Ala Lys Thr Leu Asp Val Lys
        755                 760                 765             
Ser Pro Glu Ala Lys Thr Pro Ala Lys Glu Glu Ala Arg Ser Pro Ala
    770                 775                 780                 
Asp Lys Phe Pro Glu Lys Ala Lys Ser Pro Val Lys Glu Glu Val Lys
785                 790                 795                 800 
Ser Pro Glu Lys Ala Lys Ser Pro Leu Lys Glu Asp Ala Lys Ala Pro
                805                 810                 815     
Glu Lys Glu Ile Pro Lys Lys Glu Glu Val Lys Ser Pro Val Lys Glu
            820                 825                 830         
Glu Glu Lys Pro Gln Glu Val Lys Val Lys Glu Pro Pro Lys Lys Ala
        835                 840                 845             
Glu Glu Glu Lys Ala Pro Ala Thr Pro Lys Thr Glu Glu Lys Lys Asp
    850                 855                 860                 
Ser Lys Lys Glu Glu Ala Pro Lys Lys Glu Ala Pro Lys Pro Lys Val
865                 870                 875                 880 
Glu Glu Lys Lys Glu Pro Ala Val Glu Lys Pro Lys Glu Ser Lys Val
                885                 890                 895     
Glu Ala Lys Lys Glu Glu Ala Glu Asp Lys Lys Lys Val Pro Thr Pro
            900                 905                 910         
Glu Lys Glu Ala Pro Ala Lys Val Glu Val Lys Glu Asp Ala Lys Pro
        915                 920                 925             
Lys Glu Lys Thr Glu Val Ala Lys Lys Glu Pro Asp Asp Ala Lys Ala
    930                 935                 940                 
Lys Glu Pro Ser Lys Pro Ala Glu Lys Lys Glu Ala Ala Pro Glu Lys
945                 950                 955                 960 
Lys Asp Thr Lys Glu Glu Lys Ala Lys Lys Pro Glu Glu Lys Pro Lys
                965                 970                 975     
Thr Glu Ala Lys Ala Lys Glu Asp Asp Lys Thr Leu Ser Lys Glu Pro
            980                 985                 990         
Ser Lys Pro Lys Ala Glu Lys Ala Glu Lys Ser Ser Ser Thr Asp Gln
        995                 1000                1005            
Lys Asp Ser Lys Pro Pro Glu Lys Ala Thr Glu Asp Lys Ala Ala Lys
    1010                1015                1020                
Gly Lys
1025    


<210> 1116
<211> 1198
<212> PRT
<213> Homo sapiens

<400> 1116
Met Asp Glu Glu Thr Arg His Ser Leu Glu Cys Ile Gln Ala Asn Gln
 1               5                  10                  15      
Ile Phe Pro Arg Lys Gln Leu Ile Arg Glu Asp Glu Asn Leu Gln Val
            20                  25                  30          
Pro Phe Leu Glu Leu His Gly Glu Ser Thr Glu Phe Val Gly Arg Ala
        35                  40                  45              
Glu Asp Ala Ile Ile Ala Leu Ser Asn Tyr Arg Leu His Ile Lys Phe
    50                  55                  60                  
Lys Glu Ser Leu Val Asn Val Pro Leu Gln Leu Ile Glu Ser Val Glu
65                  70                  75                  80  
Cys Arg Asp Ile Phe Gln Leu His Leu Thr Cys Lys Asp Cys Lys Val
                85                  90                  95      
Ile Arg Cys Gln Phe Ser Thr Phe Glu Gln Cys Gln Glu Trp Leu Lys
            100                 105                 110         
Arg Leu Asn Asn Ala Ile Arg Pro Pro Ala Lys Ile Glu Asp Leu Phe
        115                 120                 125             
Ser Phe Ala Tyr His Ala Trp Cys Met Glu Val Tyr Ala Ser Glu Lys
    130                 135                 140                 
Glu Gln His Gly Asp Leu Cys Arg Pro Gly Glu His Val Thr Ser Arg
145                 150                 155                 160 
Phe Lys Asn Glu Val Glu Arg Met Gly Phe Asp Met Asn Asn Ala Trp
                165                 170                 175     
Arg Ile Ser Asn Ile Asn Glu Lys Tyr Lys Leu Cys Gly Ser Tyr Pro
            180                 185                 190         
Gln Glu Leu Ile Val Pro Ala Trp Ile Thr Asp Lys Glu Leu Glu Ser
        195                 200                 205             
Val Ser Ser Phe Arg Ser Trp Lys Arg Ile Pro Ala Val Ile Tyr Arg
    210                 215                 220                 
His Gln Ser Asn Gly Ala Val Ile Ala Arg Cys Gly Gln Pro Glu Val
225                 230                 235                 240 
Ser Trp Trp Gly Trp Arg Asn Ala Asp Asp Glu His Leu Val Gln Ser
                245                 250                 255     
Val Ala Lys Ala Cys Ala Ser Asp Ser Arg Ser Ser Gly Ser Lys Leu
            260                 265                 270         
Ser Thr Arg Asn Thr Ser Arg Asp Phe Pro Asn Gly Gly Asp Leu Ser
        275                 280                 285             
Asp Val Glu Phe Asp Ser Ser Leu Ser Asn Ala Ser Gly Ala Glu Ser
    290                 295                 300                 
Leu Ala Ile Gln Pro Gln Lys Leu Leu Ile Leu Asp Ala Arg Ser Tyr
305                 310                 315                 320 
Ala Ala Ala Val Ala Asn Arg Ala Lys Gly Gly Gly Cys Glu Cys Pro
                325                 330                 335     
Glu Tyr Tyr Pro Asn Cys Glu Val Val Phe Met Gly Met Ala Asn Ile
            340                 345                 350         
His Ser Ile Arg Arg Ser Phe Gln Ser Leu Arg Leu Leu Cys Thr Gln
        355                 360                 365             
Met Pro Asp Pro Gly Asn Trp Leu Ser Ala Leu Glu Ser Thr Lys Trp
    370                 375                 380                 
Leu His His Leu Ser Val Leu Leu Lys Ser Ala Leu Leu Val Val His
385                 390                 395                 400 
Ala Val Asp Gln Asp Gln Arg Pro Val Leu Val His Cys Ser Asp Gly
                405                 410                 415     
Trp Asp Arg Thr Pro Gln Ile Val Ala Leu Ala Lys Leu Leu Leu Asp
            420                 425                 430         
Pro Tyr Tyr Arg Thr Ile Glu Gly Phe Gln Val Leu Val Glu Met Glu
        435                 440                 445             
Trp Leu Asp Phe Gly His Lys Phe Ala Asp Arg Cys Gly His Gly Glu
    450                 455                 460                 
Asn Ser Asp Asp Leu Asn Glu Arg Cys Pro Val Phe Leu Gln Trp Leu
465                 470                 475                 480 
Asp Cys Val His Gln Leu Gln Arg Gln Phe Pro Cys Ser Phe Glu Phe
                485                 490                 495     
Asn Glu Ala Phe Leu Val Lys Leu Val Gln His Thr Tyr Ser Cys Leu
            500                 505                 510         
Phe Gly Thr Phe Leu Cys Asn Asn Ala Lys Glu Arg Gly Glu Lys His
        515                 520                 525             
Thr Gln Glu Arg Thr Cys Ser Val Trp Ser Leu Leu Arg Ala Gly Asn
    530                 535                 540                 
Lys Ala Phe Lys Asn Leu Leu Tyr Ser Ser Gln Ser Glu Ala Val Leu
545                 550                 555                 560 
Tyr Pro Val Cys His Val Arg Asn Leu Met Leu Trp Ser Ala Val Tyr
                565                 570                 575     
Leu Pro Cys Pro Ser Pro Thr Thr Pro Val Asp Asp Ser Cys Ala Pro
            580                 585                 590         
Tyr Pro Ala Pro Gly Thr Ser Pro Asp Asp Pro Pro Leu Ser Arg Leu
        595                 600                 605             
Pro Lys Thr Arg Ser Tyr Asp Asn Leu Thr Thr Ala Cys Asp Asn Thr
    610                 615                 620                 
Val Pro Leu Ala Ser Arg Arg Cys Ser Asp Pro Ser Leu Asn Glu Lys
625                 630                 635                 640 
Trp Gln Glu His Arg Arg Ser Leu Glu Leu Ser Ser Leu Ala Gly Pro
                645                 650                 655     
Gly Glu Asp Pro Leu Ser Ala Asp Ser Leu Gly Lys Pro Thr Arg Val
            660                 665                 670         
Pro Gly Gly Ala Glu Leu Ser Val Ala Ala Gly Val Ala Glu Gly Gln
        675                 680                 685             
Met Glu Asn Ile Leu Gln Glu Ala Thr Lys Glu Glu Ser Gly Val Glu
    690                 695                 700                 
Glu Pro Ala His Arg Ala Gly Ile Glu Ile Gln Glu Gly Lys Glu Asp
705                 710                 715                 720 
Pro Leu Leu Glu Lys Glu Ser Arg Arg Lys Thr Pro Glu Ala Ser Ala
                725                 730                 735     
Ile Gly Leu His Gln Asp Pro Glu Leu Gly Asp Ala Ala Leu Arg Ser
            740                 745                 750         
His Leu Asp Met Ser Trp Pro Leu Phe Ser Gln Gly Ile Ser Glu Gln
        755                 760                 765             
Gln Ser Gly Leu Ser Val Leu Leu Ser Ser Leu Gln Val Pro Pro Arg
    770                 775                 780                 
Gly Glu Asp Ser Leu Glu Val Pro Val Glu Gln Phe Arg Ile Glu Glu
785                 790                 795                 800 
Ile Ala Glu Gly Arg Glu Glu Ala Val Leu Pro Ile Pro Val Asp Ala
                805                 810                 815     
Lys Val Gly Tyr Gly Thr Ser Gln Ser Cys Ser Leu Leu Pro Ser Gln
            820                 825                 830         
Val Pro Phe Glu Thr Arg Gly Pro Asn Val Asp Ser Ser Thr Asp Met
        835                 840                 845             
Leu Val Glu Asp Lys Val Lys Ser Val Ser Gly Pro Gln Gly His His
    850                 855                 860                 
Arg Ser Cys Leu Val Asn Ser Gly Lys Asp Arg Leu Pro Gln Thr Met
865                 870                 875                 880 
Glu Pro Ser Pro Ser Glu Thr Ser Leu Val Glu Arg Pro Gln Val Gly
                885                 890                 895     
Ser Val Val His Arg Thr Ser Leu Gly Ser Thr Leu Ser Leu Thr Arg
            900                 905                 910         
Ser Pro Cys Ala Leu Pro Leu Ala Glu Cys Lys Glu Gly Leu Val Cys
        915                 920                 925             
Asn Gly Ala Pro Glu Thr Glu Asn Arg Ala Ser Glu Gln Pro Pro Gly
    930                 935                 940                 
Leu Ser Thr Leu Gln Met Tyr Pro Thr Pro Asn Gly His Cys Ala Asn
945                 950                 955                 960 
Gly Glu Ala Gly Arg Ser Lys Asp Ser Leu Ser Arg Gln Leu Ser Ala
                965                 970                 975     
Met Ser Cys Ser Ser Ala His Leu His Ser Arg Asn Leu His His Lys
            980                 985                 990         
Trp Leu His Ser His Ser Gly Arg Pro Ser Ala Thr Ser Ser Pro Asp
        995                 1000                1005            
Gln Pro Ser Arg Ser His Leu Asp Asp Asp Gly Met Ser Val Tyr Thr
    1010                1015                1020                
Asp Thr Ile Gln Gln Arg Leu Arg Gln Ile Glu Ser Gly His Gln Gln
1025                1030                1035                1040
Glu Val Glu Thr Leu Lys Lys Gln Val Gln Glu Leu Lys Ser Arg Leu
                1045                1050                1055    
Glu Ser Gln Tyr Leu Thr Ser Ser Leu His Phe Asn Gly Asp Phe Gly
            1060                1065                1070        
Asp Glu Val Thr Ser Ile Pro Asp Ser Glu Ser Asn Leu Asp Gln Asn
        1075                1080                1085            
Cys Leu Ser Arg Cys Ser Thr Glu Ile Phe Ser Glu Ala Ser Trp Glu
    1090                1095                1100                
Gln Val Asp Lys Gln Asp Thr Glu Met Thr Arg Trp Leu Pro Asp His
1105                1110                1115                1120
Leu Ala Ala His Cys Tyr Ala Cys Asp Ser Ala Phe Trp Leu Ala Ser
                1125                1130                1135    
Arg Lys His His Cys Arg Asn Cys Gly Asn Val Phe Cys Ser Ser Cys
            1140                1145                1150        
Cys Asn Gln Lys Val Pro Val Pro Ser Gln Gln Leu Phe Glu Pro Ser
        1155                1160                1165            
Arg Val Cys Lys Ser Cys Tyr Ser Ser Leu His Pro Thr Ser Ser Ser
    1170                1175                1180                
Ile Asp Leu Glu Leu Asp Lys Pro Ile Ala Ala Thr Ser Asn
1185                1190                1195            


<210> 1117
<211> 233
<212> PRT
<213> Homo sapiens

<400> 1117
Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala
 1               5                  10                  15      
Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe
            20                  25                  30          
Leu Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe
        35                  40                  45              
Cys Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Ser Pro
    50                  55                  60                  
Arg Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser
65                  70                  75                  80  
Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro
                85                  90                  95      
Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu
            100                 105                 110         
Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser
        115                 120                 125             
Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly
    130                 135                 140                 
Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala
145                 150                 155                 160 
Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro
                165                 170                 175     
Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu
            180                 185                 190         
Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu
        195                 200                 205             
Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly
    210                 215                 220                 
Gln Val Tyr Phe Gly Ile Ile Ala Leu
225                 230             


<210> 1118
<211> 128
<212> PRT
<213> Homo sapiens

<400> 1118
Met Gly Ile Gln Gly Gly Ser Val Leu Phe Gly Leu Leu Leu Val Leu
 1               5                  10                  15      
Ala Val Phe Cys His Ser Gly His Ser Leu Gln Cys Tyr Asn Cys Pro
            20                  25                  30          
Asn Pro Thr Ala Asp Cys Lys Thr Ala Val Asn Cys Ser Ser Asp Phe
        35                  40                  45              
Asp Ala Cys Leu Ile Thr Lys Ala Gly Leu Gln Val Tyr Asn Lys Cys
    50                  55                  60                  
Trp Lys Phe Glu His Cys Asn Phe Asn Asp Val Thr Thr Arg Leu Arg
65                  70                  75                  80  
Glu Asn Glu Leu Thr Tyr Tyr Cys Cys Lys Lys Asp Leu Cys Asn Phe
                85                  90                  95      
Asn Glu Gln Leu Glu Asn Gly Gly Thr Ser Leu Ser Glu Lys Thr Val
            100                 105                 110         
Leu Leu Leu Val Thr Pro Phe Leu Ala Ala Ala Trp Ser Leu His Pro
        115                 120                 125             


<210> 1119
<211> 1434
<212> PRT
<213> Homo sapiens

<400> 1119
Met Glu Asp His Met Phe Gly Val Gln Gln Ile Gln Pro Asn Val Ile
 1               5                  10                  15      
Ser Val Arg Leu Phe Lys Arg Lys Val Gly Gly Leu Gly Phe Leu Val
            20                  25                  30          
Lys Glu Arg Val Ser Lys Pro Pro Val Ile Ile Ser Asp Leu Ile Arg
        35                  40                  45              
Gly Gly Ala Ala Glu Gln Ser Gly Leu Ile Gln Ala Gly Asp Ile Ile
    50                  55                  60                  
Leu Ala Val Asn Gly Arg Pro Leu Val Asp Leu Ser Tyr Asp Ser Ala
65                  70                  75                  80  
Leu Glu Val Leu Arg Gly Ile Ala Ser Glu Thr His Val Val Leu Ile
                85                  90                  95      
Leu Arg Gly Pro Glu Gly Phe Thr Thr His Leu Glu Thr Thr Phe Thr
            100                 105                 110         
Gly Asp Gly Thr Pro Lys Thr Ile Arg Val Thr Gln Pro Leu Gly Pro
        115                 120                 125             
Pro Thr Lys Ala Val Asp Leu Ser His Gln Pro Pro Ala Gly Lys Glu
    130                 135                 140                 
Gln Pro Leu Ala Val Asp Gly Ala Ser Gly Pro Gly Asn Gly Pro Gln
145                 150                 155                 160 
His Ala Tyr Asp Asp Gly Gln Glu Ala Gly Ser Leu Pro His Ala Asn
                165                 170                 175     
Gly Leu Ala Pro Arg Pro Pro Gly Gln Asp Pro Ala Lys Lys Ala Thr
            180                 185                 190         
Arg Val Ser Leu Gln Gly Arg Gly Glu Asn Asn Glu Leu Leu Lys Glu
        195                 200                 205             
Ile Glu Pro Val Leu Ser Leu Leu Thr Ser Gly Ser Arg Gly Val Lys
    210                 215                 220                 
Gly Gly Ala Pro Ala Lys Ala Glu Met Lys Asp Met Gly Ile Gln Val
225                 230                 235                 240 
Asp Arg Asp Leu Asp Gly Lys Ser His Lys Pro Leu Pro Leu Gly Val
                245                 250                 255     
Glu Asn Asp Arg Val Phe Asn Asp Leu Trp Gly Lys Gly Asn Val Pro
            260                 265                 270         
Val Val Leu Asn Asn Pro Tyr Ser Glu Lys Glu Gln Pro Pro Thr Ser
        275                 280                 285             
Gly Lys Gln Ser Pro Thr Lys Asn Gly Ser Pro Ser Lys Cys Pro Arg
    290                 295                 300                 
Phe Leu Lys Val Lys Asn Trp Glu Thr Glu Val Val Leu Thr Asp Thr
305                 310                 315                 320 
Leu His Leu Lys Ser Thr Leu Glu Thr Gly Cys Thr Glu Tyr Ile Cys
                325                 330                 335     
Met Gly Ser Ile Met His Pro Ser Gln His Ala Arg Arg Pro Glu Asp
            340                 345                 350         
Val Arg Thr Lys Gly Gln Leu Phe Pro Leu Ala Lys Glu Phe Ile Asp
        355                 360                 365             
Gln Tyr Tyr Ser Ser Ile Lys Arg Phe Gly Ser Lys Ala His Met Glu
    370                 375                 380                 
Arg Leu Glu Glu Val Asn Lys Glu Ile Asp Thr Thr Ser Thr Tyr Gln
385                 390                 395                 400 
Leu Lys Asp Thr Glu Leu Ile Tyr Gly Ala Lys His Ala Trp Arg Asn
                405                 410                 415     
Ala Ser Arg Cys Val Gly Arg Ile Gln Trp Ser Lys Leu Gln Val Phe
            420                 425                 430         
Asp Ala Arg Asp Cys Thr Thr Ala His Gly Met Phe Asn Tyr Ile Cys
        435                 440                 445             
Asn His Val Lys Tyr Ala Thr Asn Lys Gly Asn Leu Arg Ser Ala Ile
    450                 455                 460                 
Thr Ile Phe Pro Gln Arg Thr Asp Gly Lys His Asp Phe Arg Val Trp
465                 470                 475                 480 
Asn Ser Gln Leu Ile Arg Tyr Ala Gly Tyr Lys Gln Pro Asp Gly Ser
                485                 490                 495     
Thr Leu Gly Asp Pro Ala Asn Val Gln Phe Thr Glu Ile Cys Ile Gln
            500                 505                 510         
Gln Gly Trp Lys Pro Pro Arg Gly Arg Phe Asp Val Leu Pro Leu Leu
        515                 520                 525             
Leu Gln Ala Asn Gly Asn Asp Pro Glu Leu Phe Gln Ile Pro Pro Glu
    530                 535                 540                 
Leu Val Leu Glu Val Pro Ile Arg His Pro Lys Phe Glu Trp Phe Lys
545                 550                 555                 560 
Asp Leu Gly Leu Lys Trp Tyr Gly Leu Pro Ala Val Ser Asn Met Leu
                565                 570                 575     
Leu Glu Ile Gly Gly Leu Glu Phe Ser Ala Cys Pro Phe Ser Gly Trp
            580                 585                 590         
Tyr Met Gly Thr Glu Ile Gly Val Arg Asp Tyr Cys Asp Asn Ser Arg
        595                 600                 605             
Tyr Asn Ile Leu Glu Glu Val Ala Lys Lys Met Asn Leu Asp Met Arg
    610                 615                 620                 
Lys Thr Ser Ser Leu Trp Lys Asp Gln Ala Leu Val Glu Ile Asn Ile
625                 630                 635                 640 
Ala Val Leu Tyr Ser Phe Gln Ser Asp Lys Val Thr Ile Val Asp His
                645                 650                 655     
His Ser Ala Thr Glu Ser Phe Ile Lys His Met Glu Asn Glu Tyr Arg
            660                 665                 670         
Cys Arg Gly Gly Cys Pro Ala Asp Trp Val Trp Ile Val Pro Pro Met
        675                 680                 685             
Ser Gly Ser Ile Thr Pro Val Phe His Gln Glu Met Leu Asn Tyr Arg
    690                 695                 700                 
Leu Thr Pro Ser Phe Glu Tyr Gln Pro Asp Pro Trp Asn Thr His Val
705                 710                 715                 720 
Trp Lys Gly Thr Asn Gly Thr Pro Thr Lys Arg Arg Ala Ile Gly Phe
                725                 730                 735     
Lys Lys Leu Ala Glu Ala Val Lys Phe Ser Ala Lys Leu Met Gly Gln
            740                 745                 750         
Ala Met Ala Lys Arg Val Lys Ala Thr Ile Leu Tyr Ala Thr Glu Thr
        755                 760                 765             
Gly Lys Ser Gln Ala Tyr Ala Lys Thr Leu Cys Glu Ile Phe Lys His
    770                 775                 780                 
Ala Phe Asp Ala Lys Val Met Ser Met Glu Glu Tyr Asp Ile Val His
785                 790                 795                 800 
Leu Glu His Glu Thr Leu Val Leu Val Val Thr Ser Thr Phe Gly Asn
                805                 810                 815     
Gly Asp Pro Pro Glu Asn Gly Glu Lys Phe Gly Cys Ala Leu Met Glu
            820                 825                 830         
Met Arg His Pro Asn Ser Val Gln Glu Glu Arg Lys Ser Tyr Lys Val
        835                 840                 845             
Arg Phe Asn Ser Val Ser Ser Tyr Ser Asp Ser Gln Lys Ser Ser Gly
    850                 855                 860                 
Asp Gly Pro Asp Leu Arg Asp Asn Phe Glu Ser Ala Gly Pro Leu Ala
865                 870                 875                 880 
Asn Val Arg Phe Ser Val Phe Gly Leu Gly Ser Arg Ala Tyr Pro His
                885                 890                 895     
Phe Cys Ala Phe Gly His Ala Val Asp Thr Leu Leu Glu Glu Leu Gly
            900                 905                 910         
Gly Glu Arg Ile Leu Lys Met Arg Glu Gly Asp Glu Leu Cys Gly Gln
        915                 920                 925             
Glu Glu Ala Phe Arg Thr Trp Ala Lys Lys Val Phe Lys Ala Ala Cys
    930                 935                 940                 
Asp Val Phe Cys Val Gly Asp Asp Val Asn Ile Glu Lys Ala Asn Asn
945                 950                 955                 960 
Ser Leu Ile Ser Asn Asp Arg Ser Trp Lys Arg Asn Lys Phe Arg Leu
                965                 970                 975     
Thr Phe Val Ala Glu Ala Pro Glu Leu Thr Gln Gly Leu Ser Asn Val
            980                 985                 990         
His Lys Lys Arg Val Ser Ala Ala Arg Leu Leu Ser Arg Gln Asn Leu
        995                 1000                1005            
Gln Ser Pro Lys Ser Ser Arg Ser Thr Ile Phe Val Arg Leu His Thr
    1010                1015                1020                
Asn Gly Ser Gln Glu Leu Gln Tyr Gln Pro Gly Asp His Leu Gly Val
1025                1030                1035                1040
Phe Pro Gly Asn His Glu Asp Leu Val Asn Ala Leu Ile Glu Arg Leu
                1045                1050                1055    
Glu Asp Ala Pro Pro Val Asn Gln Met Val Lys Val Glu Leu Leu Glu
            1060                1065                1070        
Glu Arg Asn Thr Ala Leu Gly Val Ile Ser Asn Trp Thr Asp Glu Leu
        1075                1080                1085            
Arg Leu Pro Pro Cys Thr Ile Phe Gln Ala Phe Lys Tyr Tyr Leu Asp
    1090                1095                1100                
Ile Thr Thr Pro Pro Thr Pro Leu Gln Leu Gln Gln Phe Ala Ser Leu
1105                1110                1115                1120
Ala Thr Ser Glu Lys Glu Lys Gln Arg Leu Leu Val Leu Ser Lys Gly
                1125                1130                1135    
Leu Gln Glu Tyr Glu Glu Trp Lys Trp Gly Lys Asn Pro Thr Ile Val
            1140                1145                1150        
Glu Val Leu Glu Glu Phe Pro Ser Ile Gln Met Pro Ala Thr Leu Leu
        1155                1160                1165            
Leu Thr Gln Leu Ser Leu Leu Gln Pro Arg Tyr Tyr Ser Ile Ser Ser
    1170                1175                1180                
Ser Pro Asp Met Tyr Pro Asp Glu Val His Leu Thr Val Ala Ile Val
1185                1190                1195                1200
Ser Tyr Arg Thr Arg Asp Gly Glu Gly Pro Ile His His Gly Val Cys
                1205                1210                1215    
Ser Ser Trp Leu Asn Arg Ile Gln Ala Asp Glu Leu Val Pro Cys Phe
            1220                1225                1230        
Val Arg Gly Ala Pro Ser Phe His Leu Pro Arg Asn Pro Gln Val Pro
        1235                1240                1245            
Cys Ile Leu Val Gly Pro Gly Thr Gly Ile Ala Pro Phe Arg Ser Phe
    1250                1255                1260                
Trp Gln Gln Arg Gln Phe Asp Ile Gln His Lys Gly Met Asn Pro Cys
1265                1270                1275                1280
Pro Met Val Leu Val Phe Gly Cys Arg Gln Ser Lys Ile Asp His Ile
                1285                1290                1295    
Tyr Arg Glu Glu Thr Leu Gln Ala Lys Asn Lys Gly Val Phe Arg Glu
            1300                1305                1310        
Leu Tyr Thr Ala Tyr Ser Arg Glu Pro Asp Lys Pro Lys Lys Tyr Val
        1315                1320                1325            
Gln Asp Ile Leu Gln Glu Gln Leu Ala Glu Ser Val Tyr Arg Ala Leu
    1330                1335                1340                
Lys Glu Gln Gly Gly His Ile Tyr Val Cys Gly Asp Val Thr Met Ala
1345                1350                1355                1360
Ala Asp Val Leu Lys Ala Ile Gln Arg Ile Met Thr Gln Gln Gly Lys
                1365                1370                1375    
Leu Ser Ala Glu Asp Ala Gly Val Phe Ile Ser Arg Met Arg Asp Asp
            1380                1385                1390        
Asn Arg Tyr His Glu Asp Ile Phe Gly Val Thr Leu Arg Thr Tyr Glu
        1395                1400                1405            
Val Thr Asn Arg Leu Arg Ser Glu Ser Ile Ala Phe Ile Glu Glu Ser
    1410                1415                1420                
Lys Lys Asp Thr Asp Glu Val Phe Ser Ser
1425                1430                


<210> 1120
<211> 479
<212> PRT
<213> Homo sapiens

<400> 1120
Met Ala Cys Arg Gln Glu Pro Gln Pro Gln Gly Pro Pro Pro Ala Ala
 1               5                  10                  15      
Gly Ala Val Ala Ser Tyr Asp Tyr Leu Val Ile Gly Gly Gly Ser Gly
            20                  25                  30          
Gly Leu Ala Ser Ala Arg Arg Ala Ala Glu Leu Gly Ala Arg Ala Ala
        35                  40                  45              
Val Val Glu Ser His Lys Leu Gly Gly Thr Cys Val Asn Val Gly Cys
    50                  55                  60                  
Val Pro Lys Lys Val Met Trp Asn Thr Ala Val His Ser Glu Phe Met
65                  70                  75                  80  
His Asp His Ala Asp Tyr Gly Phe Pro Ser Cys Glu Gly Lys Phe Asn
                85                  90                  95      
Trp Arg Val Ile Lys Glu Lys Arg Asp Ala Tyr Val Ser Arg Leu Asn
            100                 105                 110         
Ala Ile Tyr Gln Asn Asn Leu Thr Lys Ser His Ile Glu Ile Ile Arg
        115                 120                 125             
Gly His Ala Ala Phe Thr Ser Asp Pro Lys Pro Thr Ile Glu Val Ser
    130                 135                 140                 
Gly Lys Lys Tyr Thr Ala Pro His Ile Leu Ile Ala Thr Gly Gly Met
145                 150                 155                 160 
Pro Ser Thr Pro His Glu Ser Gln Ile Pro Gly Ala Ser Leu Gly Ile
                165                 170                 175     
Thr Ser Asp Gly Phe Phe Gln Leu Glu Glu Leu Pro Gly Arg Ser Val
            180                 185                 190         
Ile Val Gly Ala Gly Tyr Ile Ala Val Glu Met Ala Gly Ile Leu Ser
        195                 200                 205             
Ala Leu Gly Ser Lys Thr Ser Leu Met Ile Arg His Asp Lys Val Leu
    210                 215                 220                 
Arg Ser Phe Asp Ser Met Ile Ser Thr Asn Cys Thr Glu Glu Leu Glu
225                 230                 235                 240 
Asn Ala Gly Val Glu Val Leu Lys Phe Ser Gln Val Lys Glu Val Lys
                245                 250                 255     
Lys Thr Leu Ser Gly Leu Glu Val Ser Met Val Thr Ala Val Pro Gly
            260                 265                 270         
Arg Leu Pro Val Met Thr Met Ile Pro Asp Val Asp Cys Leu Leu Trp
        275                 280                 285             
Ala Ile Gly Arg Val Pro Asn Thr Lys Asp Leu Ser Leu Asn Lys Leu
    290                 295                 300                 
Gly Ile Gln Thr Asp Asp Lys Gly His Ile Ile Val Asp Glu Phe Gln
305                 310                 315                 320 
Asn Thr Asn Val Lys Gly Ile Tyr Ala Val Gly Asp Val Cys Gly Lys
                325                 330                 335     
Ala Leu Leu Thr Pro Val Ala Ile Ala Ala Gly Arg Lys Leu Ala His
            340                 345                 350         
Arg Leu Phe Glu Tyr Lys Glu Asp Ser Lys Leu Asp Tyr Asn Asn Ile
        355                 360                 365             
Pro Thr Val Val Phe Ser His Pro Pro Ile Gly Thr Val Gly Leu Thr
    370                 375                 380                 
Glu Asp Glu Ala Ile His Lys Tyr Gly Ile Glu Asn Val Lys Thr Tyr
385                 390                 395                 400 
Ser Thr Ser Phe Thr Pro Met Tyr His Ala Val Thr Lys Arg Lys Thr
                405                 410                 415     
Lys Cys Val Met Lys Met Val Cys Ala Asn Lys Glu Glu Lys Val Val
            420                 425                 430         
Gly Ile His Met Gln Gly Leu Gly Cys Asp Glu Met Leu Gln Gly Phe
        435                 440                 445             
Ala Val Ala Val Lys Met Gly Ala Thr Lys Ala Asp Phe Asp Asn Thr
    450                 455                 460                 
Val Ala Ile His Pro Thr Ser Ser Glu Glu Leu Val Thr Leu Arg
465                 470                 475                 


<210> 1121
<211> 994
<212> PRT
<213> Homo sapiens

<400> 1121
Met Glu Ala Ala His Ala Lys Thr Thr Glu Glu Cys Leu Ala Tyr Phe
 1               5                  10                  15      
Gly Val Ser Glu Thr Thr Gly Leu Thr Pro Asp Gln Val Lys Arg Asn
            20                  25                  30          
Leu Glu Lys Tyr Gly Leu Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr
        35                  40                  45              
Leu Trp Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile
    50                  55                  60                  
Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu
65                  70                  75                  80  
Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu
                85                  90                  95      
Ile Leu Ile Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala
            100                 105                 110         
Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys
        115                 120                 125             
Val Tyr Arg Ala Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Arg Asp
    130                 135                 140                 
Ile Val Pro Gly Asp Ile Val Glu Val Ala Val Gly Asp Lys Val Pro
145                 150                 155                 160 
Ala Asp Ile Arg Ile Leu Ala Ile Lys Ser Thr Thr Leu Arg Val Asp
                165                 170                 175     
Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Glu
            180                 185                 190         
Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu
        195                 200                 205             
Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Leu Gly Ile Val Ala
    210                 215                 220                 
Thr Thr Gly Val Gly Thr Glu Ile Gly Lys Ile Arg Asp Gln Met Ala
225                 230                 235                 240 
Ala Thr Glu Gln Asp Lys Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe
                245                 250                 255     
Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Val Ala Val Trp
            260                 265                 270         
Leu Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp
        275                 280                 285             
Phe Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val
    290                 295                 300                 
Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala
305                 310                 315                 320 
Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu
                325                 330                 335     
Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys
            340                 345                 350         
Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Lys Met Phe Ile
        355                 360                 365             
Ile Asp Lys Val Asp Gly Asp Ile Cys Leu Leu Asn Glu Phe Ser Ile
    370                 375                 380                 
Thr Gly Ser Thr Tyr Ala Pro Glu Gly Glu Val Leu Lys Asn Asp Lys
385                 390                 395                 400 
Pro Val Arg Pro Gly Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile
                405                 410                 415     
Cys Ala Leu Cys Asn Asp Ser Ser Leu Asp Phe Asn Glu Ala Lys Gly
            420                 425                 430         
Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Thr Leu
        435                 440                 445             
Val Glu Lys Met Asn Val Phe Asn Thr Asp Val Arg Ser Leu Ser Lys
    450                 455                 460                 
Val Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Arg Gln Leu Met Lys
465                 470                 475                 480 
Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val
                485                 490                 495     
Tyr Cys Ser Pro Ala Lys Ser Ser Arg Ala Ala Val Gly Asn Lys Met
            500                 505                 510         
Phe Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Asn Tyr Val
        515                 520                 525             
Arg Val Gly Thr Thr Arg Val Pro Leu Thr Gly Pro Val Lys Glu Lys
    530                 535                 540                 
Ile Met Ala Val Ile Lys Glu Trp Gly Thr Gly Arg Asp Thr Leu Arg
545                 550                 555                 560 
Cys Leu Ala Leu Ala Thr Arg Asp Thr Pro Pro Lys Arg Glu Glu Met
                565                 570                 575     
Val Leu Asp Asp Ser Ala Arg Phe Leu Glu Tyr Glu Thr Asp Leu Thr
            580                 585                 590         
Phe Val Gly Val Val Gly Met Leu Asp Pro Pro Arg Lys Glu Val Thr
        595                 600                 605             
Gly Ser Ile Gln Leu Cys Arg Asp Ala Gly Ile Arg Val Ile Met Ile
    610                 615                 620                 
Thr Gly Asp Asn Lys Gly Thr Ala Ile Ala Ile Cys Arg Arg Ile Gly
625                 630                 635                 640 
Ile Phe Gly Glu Asn Glu Glu Val Ala Asp Arg Ala Tyr Thr Gly Arg
                645                 650                 655     
Glu Phe Asp Asp Leu Pro Leu Ala Glu Gln Arg Glu Ala Cys Arg Arg
            660                 665                 670         
Ala Cys Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val
        675                 680                 685             
Glu Tyr Leu Gln Ser Tyr Asp Glu Ile Thr Ala Met Thr Gly Asp Gly
    690                 695                 700                 
Val Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met
705                 710                 715                 720 
Gly Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala
                725                 730                 735     
Asp Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala
            740                 745                 750         
Ile Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn
        755                 760                 765             
Val Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Leu Pro
    770                 775                 780                 
Glu Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp
785                 790                 795                 800 
Gly Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile
                805                 810                 815     
Met Asp Arg Pro Pro Arg Ser Pro Lys Glu Pro Leu Ile Ser Gly Trp
            820                 825                 830         
Leu Phe Phe Arg Tyr Met Ala Ile Gly Gly Tyr Val Gly Ala Ala Thr
        835                 840                 845             
Val Gly Ala Ala Ala Trp Trp Phe Leu Tyr Ala Glu Asp Gly Pro His
    850                 855                 860                 
Val Asn Tyr Ser Gln Leu Thr His Phe Met Gln Cys Thr Glu Asp Asn
865                 870                 875                 880 
Thr His Phe Glu Gly Ile Asp Cys Glu Val Phe Glu Ala Pro Glu Pro
                885                 890                 895     
Met Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala
            900                 905                 910         
Leu Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp
        915                 920                 925             
Val Asn Ile Trp Leu Leu Gly Ser Ile Cys Leu Ser Met Ser Leu His
    930                 935                 940                 
Phe Leu Ile Leu Tyr Val Asp Pro Leu Pro Met Ile Phe Lys Leu Arg
945                 950                 955                 960 
Ala Leu Asp Leu Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro
                965                 970                 975     
Val Ile Gly Leu Asp Glu Ile Leu Lys Phe Val Ala Arg Asn Tyr Leu
            980                 985                 990         
Glu Gly
        


<210> 1122
<211> 606
<212> PRT
<213> Homo sapiens

<400> 1122
Met Ser Asp Thr Ser Glu Ser Gly Ala Gly Leu Thr Arg Phe Gln Ala
 1               5                  10                  15      
Glu Ala Ser Glu Lys Asp Ser Ser Ser Met Met Gln Thr Leu Leu Thr
            20                  25                  30          
Val Thr Gln Asn Val Glu Val Pro Glu Thr Pro Lys Ala Ser Lys Ala
        35                  40                  45              
Leu Glu Val Ser Glu Asp Val Lys Val Ser Lys Ala Ser Gly Val Ser
    50                  55                  60                  
Lys Ala Thr Glu Val Ser Lys Thr Pro Glu Ala Arg Glu Ala Pro Ala
65                  70                  75                  80  
Thr Gln Ala Ser Ser Thr Thr Gln Leu Thr Asp Thr Gln Val Leu Ala
                85                  90                  95      
Ala Glu Asn Lys Ser Leu Ala Ala Asp Thr Lys Lys Gln Asn Ala Asp
            100                 105                 110         
Pro Gln Ala Val Thr Met Pro Ala Thr Glu Thr Lys Lys Val Ser His
        115                 120                 125             
Val Ala Asp Thr Lys Val Asn Thr Lys Ala Gln Glu Thr Glu Ala Ala
    130                 135                 140                 
Pro Ser Gln Ala Pro Ala Asp Glu Pro Glu Pro Glu Ser Ala Ala Ala
145                 150                 155                 160 
Gln Ser Gln Glu Asn Gln Asp Thr Arg Pro Lys Val Lys Ala Lys Lys
                165                 170                 175     
Ala Arg Lys Val Lys His Leu Asp Gly Glu Glu Asp Gly Ser Ser Asp
            180                 185                 190         
Gln Ser Gln Ala Ser Gly Thr Thr Gly Gly Arg Arg Val Ser Lys Ala
        195                 200                 205             
Leu Met Ala Ser Met Ala Arg Arg Ala Ser Arg Gly Pro Ile Ala Phe
    210                 215                 220                 
Trp Ala Arg Arg Ala Ser Arg Thr Arg Leu Ala Ala Trp Ala Arg Arg
225                 230                 235                 240 
Ala Leu Leu Ser Leu Arg Ser Pro Lys Ala Arg Arg Gly Lys Ala Arg
                245                 250                 255     
Arg Arg Ala Ala Lys Leu Gln Ser Ser Gln Glu Pro Glu Ala Pro Pro
            260                 265                 270         
Pro Arg Asp Val Ala Leu Leu Gln Gly Arg Ala Asn Asp Leu Val Lys
        275                 280                 285             
Tyr Leu Leu Ala Lys Asp Gln Thr Lys Ile Pro Ile Lys Arg Ser Asp
    290                 295                 300                 
Met Leu Lys Asp Ile Ile Lys Glu Tyr Thr Asp Val Tyr Pro Glu Ile
305                 310                 315                 320 
Ile Glu Arg Ala Gly Tyr Ser Leu Glu Lys Val Phe Gly Ile Gln Leu
                325                 330                 335     
Lys Glu Ile Asp Lys Asn Asp His Leu Tyr Ile Leu Leu Ser Thr Leu
            340                 345                 350         
Glu Pro Thr Asp Ala Gly Ile Leu Gly Thr Thr Lys Asp Ser Pro Lys
        355                 360                 365             
Leu Gly Leu Leu Met Val Leu Leu Ser Ile Ile Phe Met Asn Gly Asn
    370                 375                 380                 
Arg Ser Ser Glu Ala Val Ile Trp Glu Val Leu Arg Lys Leu Gly Leu
385                 390                 395                 400 
Arg Pro Gly Ile His His Ser Leu Phe Gly Asp Val Lys Lys Leu Ile
                405                 410                 415     
Thr Asp Glu Phe Val Lys Gln Lys Tyr Leu Asp Tyr Ala Arg Val Pro
            420                 425                 430         
Asn Ser Asn Pro Pro Glu Tyr Glu Phe Phe Trp Gly Leu Arg Ser Tyr
        435                 440                 445             
Tyr Glu Thr Ser Lys Met Lys Val Leu Lys Phe Ala Cys Lys Val Gln
    450                 455                 460                 
Lys Lys Asp Pro Lys Glu Trp Ala Ala Gln Tyr Arg Glu Ala Met Glu
465                 470                 475                 480 
Ala Asp Leu Lys Ala Ala Ala Glu Ala Ala Ala Glu Ala Lys Ala Arg
                485                 490                 495     
Ala Glu Ile Arg Ala Arg Met Gly Ile Gly Leu Gly Ser Glu Asn Ala
            500                 505                 510         
Ala Gly Pro Cys Asn Trp Asp Glu Ala Asp Ile Gly Pro Trp Ala Lys
        515                 520                 525             
Ala Arg Ile Gln Ala Gly Ala Glu Ala Lys Ala Lys Ala Gln Glu Ser
    530                 535                 540                 
Gly Ser Ala Ser Thr Gly Ala Ser Thr Ser Thr Asn Asn Ser Ala Ser
545                 550                 555                 560 
Ala Ser Ala Ser Thr Ser Gly Gly Phe Ser Ala Gly Ala Ser Leu Thr
                565                 570                 575     
Ala Thr Leu Thr Phe Gly Leu Phe Ala Gly Leu Gly Gly Ala Gly Ala
            580                 585                 590         
Ser Thr Ser Gly Ser Ser Gly Ala Cys Gly Phe Ser Tyr Lys
        595                 600                 605     


<210> 1123
<211> 165
<212> PRT
<213> Homo sapiens

<400> 1123
Met Val Asn Pro Thr Val Phe Phe Asp Ile Ala Val Asp Gly Glu Pro
 1               5                  10                  15      
Leu Gly Arg Val Ser Phe Glu Leu Phe Ala Asp Lys Val Pro Lys Thr
            20                  25                  30          
Ala Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu Lys Gly Phe Gly Tyr
        35                  40                  45              
Lys Gly Ser Cys Phe His Arg Ile Ile Pro Gly Phe Met Cys Gln Gly
    50                  55                  60                  
Gly Asp Phe Thr Arg His Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly
65                  70                  75                  80  
Glu Lys Phe Glu Asp Glu Asn Phe Ile Leu Lys His Thr Gly Pro Gly
                85                  90                  95      
Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe
            100                 105                 110         
Phe Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp Gly Lys His Val Val
        115                 120                 125             
Phe Gly Lys Val Lys Glu Gly Met Asn Ile Val Glu Ala Met Glu Arg
    130                 135                 140                 
Phe Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys Ile Thr Ile Ala Asp
145                 150                 155                 160 
Cys Gly Gln Leu Glu
                165 


<210> 1124
<211> 732
<212> PRT
<213> Homo sapiens

<400> 1124
Met Val Arg Ser Gly Asn Lys Ala Ala Val Val Leu Cys Met Asp Val
 1               5                  10                  15      
Gly Phe Thr Met Ser Asn Ser Ile Pro Gly Ile Glu Ser Pro Phe Glu
            20                  25                  30          
Gln Ala Lys Lys Val Ile Thr Met Phe Val Gln Arg Gln Val Phe Ala
        35                  40                  45              
Glu Asn Lys Asp Glu Ile Ala Leu Val Leu Phe Gly Thr Asp Gly Thr
    50                  55                  60                  
Asp Asn Pro Leu Ser Gly Gly Asp Gln Tyr Gln Asn Ile Thr Val His
65                  70                  75                  80  
Arg His Leu Met Leu Pro Asp Phe Asp Leu Leu Glu Asp Ile Glu Ser
                85                  90                  95      
Lys Ile Gln Pro Gly Ser Gln Gln Ala Asp Phe Leu Asp Ala Leu Ile
            100                 105                 110         
Val Ser Met Asp Val Ile Gln His Glu Thr Ile Gly Lys Lys Phe Glu
        115                 120                 125             
Lys Arg His Ile Glu Ile Phe Thr Asp Leu Ser Ser Arg Phe Ser Lys
    130                 135                 140                 
Ser Gln Leu Asp Ile Ile Ile His Ser Leu Lys Lys Cys Asp Ile Ser
145                 150                 155                 160 
Leu Gln Phe Phe Leu Pro Phe Ser Leu Gly Lys Glu Asp Gly Ser Gly
                165                 170                 175     
Asp Arg Gly Asp Gly Pro Phe Arg Leu Gly Gly His Gly Pro Ser Phe
            180                 185                 190         
Pro Leu Lys Gly Ile Thr Glu Gln Gln Lys Glu Gly Leu Glu Ile Val
        195                 200                 205             
Lys Met Val Met Ile Ser Leu Glu Gly Glu Asp Gly Leu Asp Glu Ile
    210                 215                 220                 
Tyr Ser Phe Ser Glu Ser Leu Arg Lys Leu Cys Val Phe Lys Lys Ile
225                 230                 235                 240 
Glu Arg His Ser Ile His Trp Pro Cys Arg Leu Thr Ile Gly Ser Asn
                245                 250                 255     
Leu Ser Ile Arg Ile Ala Ala Tyr Lys Ser Ile Leu Gln Glu Arg Val
            260                 265                 270         
Lys Lys Thr Trp Thr Val Val Asp Ala Lys Thr Leu Lys Lys Glu Asp
        275                 280                 285             
Ile Gln Lys Glu Thr Val Tyr Cys Leu Asn Asp Asp Asp Glu Thr Glu
    290                 295                 300                 
Val Leu Lys Glu Asp Ile Ile Gln Gly Phe Arg Tyr Gly Ser Asp Ile
305                 310                 315                 320 
Val Pro Phe Ser Lys Val Asp Glu Glu Gln Met Lys Tyr Lys Ser Glu
                325                 330                 335     
Gly Lys Cys Phe Ser Val Leu Gly Phe Cys Lys Ser Ser Gln Val Gln
            340                 345                 350         
Arg Arg Phe Phe Met Gly Asn Gln Val Leu Lys Val Phe Ala Ala Arg
        355                 360                 365             
Asp Asp Glu Ala Ala Ala Val Ala Leu Ser Ser Leu Ile His Ala Leu
    370                 375                 380                 
Asp Asp Leu Asp Met Val Ala Ile Val Arg Tyr Ala Tyr Asp Lys Arg
385                 390                 395                 400 
Ala Asn Pro Gln Val Gly Val Ala Phe Pro His Ile Lys His Asn Tyr
                405                 410                 415     
Glu Cys Leu Val Tyr Val Gln Leu Pro Phe Met Glu Asp Leu Arg Gln
            420                 425                 430         
Tyr Met Phe Ser Ser Leu Lys Asn Ser Lys Lys Tyr Ala Pro Thr Glu
        435                 440                 445             
Ala Gln Leu Asn Ala Val Asp Ala Leu Ile Asp Ser Met Ser Leu Ala
    450                 455                 460                 
Lys Lys Asp Glu Lys Thr Asp Thr Leu Glu Asp Leu Phe Pro Thr Thr
465                 470                 475                 480 
Lys Ile Pro Asn Pro Arg Phe Gln Arg Leu Phe Gln Cys Leu Leu His
                485                 490                 495     
Arg Ala Leu His Pro Arg Glu Pro Leu Pro Pro Ile Gln Gln His Ile
            500                 505                 510         
Trp Asn Met Leu Asn Pro Pro Ala Glu Val Thr Thr Lys Ser Gln Ile
        515                 520                 525             
Pro Leu Ser Lys Ile Lys Thr Leu Phe Pro Leu Ile Glu Ala Lys Lys
    530                 535                 540                 
Lys Asp Gln Val Thr Ala Gln Glu Ile Phe Gln Asp Asn His Glu Asp
545                 550                 555                 560 
Gly Pro Thr Ala Lys Lys Leu Lys Thr Glu Gln Gly Gly Ala His Phe
                565                 570                 575     
Ser Val Ser Ser Leu Ala Glu Gly Ser Val Thr Ser Val Gly Ser Val
            580                 585                 590         
Asn Pro Ala Glu Asn Phe Arg Val Leu Val Lys Gln Lys Lys Ala Ser
        595                 600                 605             
Phe Glu Glu Ala Ser Asn Gln Leu Ile Asn His Ile Glu Gln Phe Leu
    610                 615                 620                 
Asp Thr Asn Glu Thr Pro Tyr Phe Met Lys Ser Ile Asp Cys Ile Arg
625                 630                 635                 640 
Ala Phe Arg Glu Glu Ala Ile Lys Phe Ser Glu Glu Gln Arg Phe Asn
                645                 650                 655     
Asn Phe Leu Lys Ala Leu Gln Glu Lys Val Glu Ile Lys Gln Leu Asn
            660                 665                 670         
His Phe Trp Glu Ile Val Val Gln Asp Gly Ile Thr Leu Ile Thr Lys
        675                 680                 685             
Glu Glu Ala Ser Gly Ser Ser Val Thr Ala Glu Glu Ala Lys Lys Phe
    690                 695                 700                 
Leu Ala Pro Lys Asp Lys Pro Ser Gly Asp Thr Ala Ala Val Phe Glu
705                 710                 715                 720 
Glu Gly Gly Asp Val Asp Asp Leu Leu Asp Met Ile
                725                 730         


<210> 1125
<211> 312
<212> PRT
<213> Homo sapiens

<400> 1125
Met Phe Leu Arg Arg Leu Gly Gly Trp Leu Pro Arg Pro Trp Gly Arg
 1               5                  10                  15      
Arg Lys Pro Met Arg Pro Asp Pro Pro Tyr Pro Glu Pro Arg Arg Val
            20                  25                  30          
Asp Ser Ser Ser Glu Asn Ser Gly Ser Asp Trp Asp Ser Ala Pro Glu
        35                  40                  45              
Thr Met Glu Asp Val Gly His Pro Lys Thr Lys Asp Ser Gly Ala Leu
    50                  55                  60                  
Arg Val Ser Arg Ala Ala Ser Glu Pro Ser Lys Glu Glu Pro Gln Val
65                  70                  75                  80  
Glu Gln Leu Gly Ser Lys Arg Met Asp Ser Leu Lys Trp Asp Gln Pro
                85                  90                  95      
Ile Ser Ser Thr Gln Glu Ser Gly Arg Leu Glu Ala Gly Gly Ala Ser
            100                 105                 110         
Pro Lys Leu Arg Trp Asp His Val Asp Ser Gly Gly Thr Arg Arg Pro
        115                 120                 125             
Gly Val Ser Pro Glu Gly Asp Ser Ser Val Pro Gly Pro Gly Ala Pro
    130                 135                 140                 
Leu Glu Lys Pro Gly Arg Arg Glu Lys Leu Leu Gly Trp Leu Arg Gly
145                 150                 155                 160 
Glu Pro Gly Ala Pro Ser Arg Tyr Leu Gly Gly Pro Glu Glu Cys Leu
                165                 170                 175     
Gln Ile Ser Thr Asn Leu Thr Leu His Leu Leu Glu Leu Leu Ala Ser
            180                 185                 190         
Ala Leu Leu Ala Leu Cys Ser Arg Pro Leu Arg Ala Ala Leu Asp Thr
        195                 200                 205             
Leu Gly Leu Arg Gly Pro Leu Gly Leu Trp Leu His Gly Leu Leu Ser
    210                 215                 220                 
Phe Leu Ala Ala Leu His Gly Leu His Ala Val Leu Ser Leu Leu Thr
225                 230                 235                 240 
Ala His Pro Leu His Phe Ala Cys Leu Phe Gly Leu Leu Gln Ala Leu
                245                 250                 255     
Val Leu Ala Val Ser Ser Gly Ser Pro Met Gly Met Arg Arg Pro Leu
            260                 265                 270         
Thr Gly Arg Val Arg Gly Trp Arg Gly Lys Val Arg Ser Arg Gly Glu
        275                 280                 285             
Thr Arg Glu Arg Gly Cys Asp Arg Gly Val Gly Ala Lys Gly Glu Glu
    290                 295                 300                 
Ser Val Gly Phe Arg Arg Lys Val
305                 310         


<210> 1126
<211> 450
<212> PRT
<213> Homo sapiens

<400> 1126
Met Val Pro Leu Val Ala Val Val Ser Gly Pro Arg Ala Gln Leu Phe
 1               5                  10                  15      
Ala Cys Leu Leu Arg Leu Gly Thr Gln Gln Val Gly Pro Leu Gln Leu
            20                  25                  30          
His Thr Gly Ala Ser His Ala Ala Arg Asn His Tyr Glu Val Leu Val
        35                  40                  45              
Leu Gly Gly Gly Ser Gly Gly Ile Thr Met Ala Ala Arg Met Lys Arg
    50                  55                  60                  
Lys Val Gly Ala Glu Asn Val Ala Ile Val Glu Pro Ser Glu Arg His
65                  70                  75                  80  
Phe Tyr Gln Pro Ile Trp Thr Leu Val Gly Ala Gly Ala Lys Gln Leu
                85                  90                  95      
Ser Ser Ser Gly Arg Pro Thr Ala Ser Val Ile Pro Ser Gly Val Glu
            100                 105                 110         
Trp Ile Lys Ala Arg Val Thr Glu Leu Asn Pro Asp Lys Asn Cys Ile
        115                 120                 125             
His Thr Asp Asp Asp Glu Lys Ile Ser Tyr Arg Tyr Leu Ile Ile Ala
    130                 135                 140                 
Leu Gly Ile Gln Leu Asp Tyr Glu Lys Ile Lys Gly Leu Pro Glu Gly
145                 150                 155                 160 
Phe Ala His Pro Lys Ile Gly Ser Asn Tyr Ser Val Lys Thr Val Glu
                165                 170                 175     
Lys Thr Trp Lys Ala Leu Gln Asp Phe Lys Glu Gly Asn Ala Ile Phe
            180                 185                 190         
Thr Phe Pro Asn Thr Pro Val Lys Cys Ala Gly Ala Pro Gln Lys Ile
        195                 200                 205             
Met Tyr Leu Ser Glu Ala Tyr Phe Arg Lys Thr Gly Lys Arg Ser Lys
    210                 215                 220                 
Ala Asn Ile Ile Phe Asn Thr Ser Leu Gly Ala Ile Phe Gly Val Lys
225                 230                 235                 240 
Lys Tyr Ala Asp Ala Leu Gln Glu Ile Ile Gln Glu Arg Asn Leu Thr
                245                 250                 255     
Val Asn Tyr Lys Lys Asn Leu Ile Glu Val Arg Ala Asp Lys Gln Glu
            260                 265                 270         
Ala Val Phe Glu Asn Leu Asp Lys Pro Gly Glu Thr Gln Val Ile Ser
        275                 280                 285             
Tyr Glu Met Leu His Val Thr Pro Pro Met Ser Pro Pro Asp Val Leu
    290                 295                 300                 
Lys Thr Ser Pro Val Ala Asp Ala Ala Gly Trp Val Asp Val Asp Lys
305                 310                 315                 320 
Glu Thr Leu Gln His Arg Arg Tyr Pro Asn Val Phe Gly Ile Gly Asp
                325                 330                 335     
Cys Thr Asn Leu Pro Thr Ser Lys Thr Ala Ala Ala Val Ala Ala Gln
            340                 345                 350         
Ser Gly Ile Leu Asp Arg Thr Ile Ser Val Ile Met Lys Asn Gln Thr
        355                 360                 365             
Pro Thr Lys Lys Tyr Asp Gly Tyr Thr Ser Cys Pro Leu Val Thr Gly
    370                 375                 380                 
Tyr Asn Arg Val Ile Leu Ala Glu Phe Asp Tyr Lys Ala Glu Pro Leu
385                 390                 395                 400 
Glu Thr Phe Pro Phe Asp Gln Ser Lys Glu Arg Leu Ser Met Tyr Leu
                405                 410                 415     
Met Lys Ala Asp Leu Met Pro Phe Leu Tyr Trp Asn Met Met Leu Arg
            420                 425                 430         
Gly Tyr Trp Gly Gly Pro Ala Phe Leu Arg Lys Leu Phe His Leu Gly
        435                 440                 445             
Met Ser
    450 


<210> 1127
<211> 536
<212> PRT
<213> Homo sapiens

<400> 1127
Met Ser Pro Arg Val Val Ser Asn Ser Ser Val Leu Ala Ser Gln Ser
 1               5                  10                  15      
Val Gly Ile Thr Asn Val Arg Thr Val Phe Ser Asn Val Phe Asn Asn
            20                  25                  30          
Thr Thr Ala Phe Pro Ile Leu Arg Gly Ser Asn Cys His Lys Ile Thr
        35                  40                  45              
Ala Pro Gly Leu Gly Lys Gly Gln Leu Val Asn Leu Leu Pro Pro Glu
    50                  55                  60                  
Asn Leu Pro Trp Cys Gly Gly Ser Gln Gly Pro Arg Met Leu Arg Thr
65                  70                  75                  80  
Cys Tyr Val Leu Cys Ser Gln Ala Gly Pro Pro Ser Arg Gly Trp Gln
                85                  90                  95      
Ser Leu Ser Phe Asp Gly Gly Ala Phe His Leu Lys Gly Thr Gly Glu
            100                 105                 110         
Leu Thr Arg Ala Leu Leu Val Leu Arg Leu Cys Ala Trp Pro Pro Leu
        115                 120                 125             
Val Thr His Gly Leu Leu Leu Gln Ala Trp Ser Arg Arg Leu Leu Gly
    130                 135                 140                 
Ser Arg Leu Ser Gly Ala Phe Leu Arg Ala Ser Val Tyr Gly Gln Phe
145                 150                 155                 160 
Val Ala Gly Glu Thr Ala Glu Glu Val Lys Gly Cys Val Gln Gln Leu
                165                 170                 175     
Arg Thr Leu Ser Leu Arg Pro Leu Leu Ala Val Pro Thr Glu Glu Glu
            180                 185                 190         
Pro Asp Ser Ala Ala Lys Ser Gly Glu Ala Trp Tyr Glu Gly Asn Leu
        195                 200                 205             
Gly Ala Met Leu Arg Cys Val Asp Leu Ser Arg Gly Leu Leu Glu Pro
    210                 215                 220                 
Pro Ser Leu Ala Glu Ala Ser Leu Met Gln Leu Lys Val Thr Ala Leu
225                 230                 235                 240 
Thr Ser Thr Arg Leu Cys Lys Glu Leu Ala Ser Trp Val Arg Arg Pro
                245                 250                 255     
Gly Ala Ser Leu Glu Leu Ser Pro Glu Arg Leu Ala Glu Ala Met Asp
            260                 265                 270         
Ser Gly Gln Asn Leu Gln Val Ser Cys Leu Asn Ala Glu Gln Asn Gln
        275                 280                 285             
His Leu Arg Ala Ser Leu Ser Arg Leu His Arg Val Ala Gln Tyr Ala
    290                 295                 300                 
Arg Ala Gln His Val Arg Leu Leu Val Asp Ala Glu Tyr Thr Ser Leu
305                 310                 315                 320 
Asn Pro Ala Leu Ser Leu Leu Val Ala Ala Leu Ala Val Arg Trp Asn
                325                 330                 335     
Ser Pro Gly Glu Gly Gly Pro Trp Val Trp Asn Thr Tyr Gln Ala Cys
            340                 345                 350         
Leu Lys Asp Thr Phe Glu Arg Leu Gly Arg Asp Ala Glu Ala Ala His
        355                 360                 365             
Arg Ala Gly Leu Ala Phe Gly Val Lys Leu Val Arg Gly Ala Tyr Leu
    370                 375                 380                 
Asp Lys Glu Arg Ala Val Ala Gln Leu His Gly Met Glu Asp Pro Thr
385                 390                 395                 400 
Gln Pro Asp Tyr Glu Ala Thr Ser Gln Ser Tyr Ser Arg Cys Leu Glu
                405                 410                 415     
Leu Met Leu Thr His Val Ala Arg His Gly Pro Met Cys His Leu Met
            420                 425                 430         
Val Ala Ser His Asn Glu Glu Ser Val Arg Gln Ala Thr Lys Arg Met
        435                 440                 445             
Trp Glu Leu Gly Ile Pro Leu Asp Gly Thr Val Cys Phe Gly Gln Leu
    450                 455                 460                 
Leu Gly Met Cys Asp His Val Ser Leu Ala Leu Gly Gln Ala Gly Tyr
465                 470                 475                 480 
Val Val Tyr Lys Ser Ile Pro Tyr Gly Ser Leu Glu Glu Val Ile Pro
                485                 490                 495     
Tyr Leu Ile Arg Arg Ala Gln Glu Asn Arg Ser Val Leu Gln Gly Ala
            500                 505                 510         
Arg Arg Glu Gln Glu Leu Leu Ser Gln Glu Leu Trp Arg Arg Leu Leu
        515                 520                 525             
Pro Gly Cys Arg Arg Ile Pro His
    530                 535     


<210> 1128
<211> 2353
<212> PRT
<213> Homo sapiens

<400> 1128
Met Thr Glu Gly Ala Arg Ala Ala Asp Glu Val Arg Val Pro Leu Gly
 1               5                  10                  15      
Ala Pro Pro Pro Gly Pro Ala Ala Leu Val Gly Ala Ser Pro Glu Ser
            20                  25                  30          
Pro Gly Ala Pro Gly Arg Glu Ala Glu Arg Gly Ser Glu Leu Gly Val
        35                  40                  45              
Ser Pro Ser Glu Ser Pro Ala Ala Glu Arg Gly Ala Glu Leu Gly Ala
    50                  55                  60                  
Asp Glu Glu Gln Arg Val Pro Tyr Pro Ala Leu Ala Ala Thr Val Phe
65                  70                  75                  80  
Phe Cys Leu Gly Gln Thr Thr Arg Pro Arg Ser Trp Cys Leu Arg Leu
                85                  90                  95      
Val Cys Asn Pro Trp Phe Glu His Val Ser Met Leu Val Ile Met Leu
            100                 105                 110         
Asn Cys Val Thr Leu Gly Met Phe Arg Pro Cys Glu Asp Val Glu Cys
        115                 120                 125             
Gly Ser Glu Arg Cys Asn Ile Leu Glu Ala Phe Asp Ala Phe Ile Phe
    130                 135                 140                 
Ala Phe Phe Ala Val Glu Met Val Ile Lys Met Val Ala Leu Gly Leu
145                 150                 155                 160 
Phe Gly Gln Lys Cys Tyr Leu Gly Asp Thr Trp Asn Arg Leu Asp Phe
                165                 170                 175     
Phe Ile Val Val Ala Gly Met Met Glu Tyr Ser Leu Asp Gly His Asn
            180                 185                 190         
Val Ser Leu Ser Ala Ile Arg Thr Val Arg Val Leu Arg Pro Leu Arg
        195                 200                 205             
Ala Ile Asn Arg Val Pro Ser Met Arg Ile Leu Val Thr Leu Leu Leu
    210                 215                 220                 
Asp Thr Leu Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val
225                 230                 235                 240 
Phe Phe Ile Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu
                245                 250                 255     
Arg Asn Arg Cys Phe Leu Asp Ser Ala Phe Val Arg Asn Asn Asn Leu
            260                 265                 270         
Thr Phe Leu Arg Pro Tyr Tyr Gln Thr Glu Glu Gly Glu Glu Asn Pro
        275                 280                 285             
Phe Ile Cys Ser Ser Arg Arg Asp Asn Gly Met Gln Lys Cys Ser His
    290                 295                 300                 
Ile Pro Gly Arg Arg Glu Leu Arg Met Pro Cys Thr Leu Gly Trp Glu
305                 310                 315                 320 
Ala Tyr Thr Gln Pro Gln Ala Glu Gly Val Gly Ala Ala Arg Asn Ala
                325                 330                 335     
Cys Ile Asn Trp Asn Gln Tyr Tyr Asn Val Cys Arg Ser Gly Asp Ser
            340                 345                 350         
Asn Pro His Asn Gly Ala Ile Asn Phe Asp Asn Ile Gly Tyr Ala Trp
        355                 360                 365             
Ile Ala Ile Phe Gln Val Ile Thr Leu Glu Gly Trp Val Asp Ile Met
    370                 375                 380                 
Tyr Tyr Val Met Asp Ala His Ser Phe Tyr Asn Phe Ile Tyr Phe Ile
385                 390                 395                 400 
Leu Leu Ile Ile Val Gly Ser Phe Phe Met Ile Asn Leu Cys Leu Val
                405                 410                 415     
Val Ile Ala Thr Gln Phe Ser Glu Thr Lys Gln Arg Glu Ser Gln Leu
            420                 425                 430         
Met Arg Glu Gln Arg Ala Arg His Leu Ser Asn Asp Ser Thr Leu Ala
        435                 440                 445             
Ser Phe Ser Glu Pro Gly Ser Cys Tyr Glu Glu Leu Leu Lys Tyr Val
    450                 455                 460                 
Gly His Ile Phe Arg Lys Val Lys Arg Arg Ser Leu Arg Leu Tyr Ala
465                 470                 475                 480 
Arg Trp Gln Ser Arg Trp Arg Lys Lys Val Asp Pro Ser Ala Val Gln
                485                 490                 495     
Gly Gln Gly Pro Gly His Arg Gln Arg Arg Ala Gly Arg His Thr Ala
            500                 505                 510         
Ser Val His His Leu Val Tyr His His His His His His His His His
        515                 520                 525             
Tyr His Phe Ser His Gly Ser Pro Arg Arg Pro Gly Pro Glu Pro Gly
    530                 535                 540                 
Ala Cys Asp Thr Arg Leu Val Arg Ala Gly Ala Pro Pro Ser Pro Pro
545                 550                 555                 560 
Ser Pro Gly Arg Gly Pro Pro Asp Ala Glu Ser Val His Ser Ile Tyr
                565                 570                 575     
His Ala Asp Cys His Ile Glu Gly Pro Gln Glu Arg Ala Arg Val Ala
            580                 585                 590         
His Ala Ala Ala Thr Ala Ala Ala Ser Leu Arg Leu Ala Thr Gly Leu
        595                 600                 605             
Gly Thr Met Asn Tyr Pro Thr Ile Leu Pro Ser Gly Val Gly Ser Gly
    610                 615                 620                 
Lys Gly Ser Thr Ser Pro Gly Pro Lys Gly Lys Trp Ala Gly Gly Pro
625                 630                 635                 640 
Pro Gly Thr Gly Gly His Gly Pro Leu Ser Leu Asn Ser Pro Asp Pro
                645                 650                 655     
Tyr Glu Lys Ile Pro His Val Val Gly Glu His Gly Leu Gly Gln Ala
            660                 665                 670         
Pro Gly His Leu Ser Gly Leu Ser Val Pro Cys Pro Leu Pro Ser Pro
        675                 680                 685             
Pro Ala Gly Thr Leu Thr Cys Glu Leu Lys Ser Cys Pro Tyr Cys Thr
    690                 695                 700                 
Arg Ala Leu Glu Asp Pro Glu Gly Glu Leu Ser Gly Ser Glu Ser Gly
705                 710                 715                 720 
Asp Ser Asp Gly Arg Gly Val Tyr Glu Phe Thr Gln Asp Val Arg His
                725                 730                 735     
Gly Asp Arg Trp Asp Pro Thr Arg Pro Pro Arg Ala Thr Asp Thr Pro
            740                 745                 750         
Gly Pro Gly Pro Gly Ser Pro Gln Arg Arg Ala Gln Gln Arg Ala Ala
        755                 760                 765             
Pro Gly Glu Pro Gly Trp Met Gly Arg Leu Trp Val Thr Phe Ser Gly
    770                 775                 780                 
Lys Leu Arg Arg Ile Val Asp Ser Lys Tyr Phe Ser Arg Gly Ile Met
785                 790                 795                 800 
Met Ala Ile Leu Val Asn Thr Leu Ser Met Gly Val Glu Tyr His Glu
                805                 810                 815     
Gln Pro Glu Glu Leu Thr Asn Ala Leu Glu Ile Ser Asn Ile Val Phe
            820                 825                 830         
Thr Ser Met Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Ala Cys Gly
        835                 840                 845             
Pro Leu Gly Tyr Ile Arg Asn Pro Tyr Asn Ile Phe Asp Gly Ile Ile
    850                 855                 860                 
Val Val Ile Ser Val Trp Glu Ile Val Gly Gln Ala Asp Gly Gly Leu
865                 870                 875                 880 
Ser Val Leu Arg Thr Phe Arg Leu Leu Arg Val Leu Lys Leu Val Arg
                885                 890                 895     
Phe Leu Pro Ala Leu Arg Arg Gln Leu Val Val Leu Val Lys Thr Met
            900                 905                 910         
Asp Asn Val Ala Thr Phe Cys Thr Leu Leu Met Leu Phe Ile Phe Ile
        915                 920                 925             
Phe Ser Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ser Leu Lys
    930                 935                 940                 
Thr Asp Thr Gly Asp Thr Val Pro Asp Arg Lys Asn Phe Asp Ser Leu
945                 950                 955                 960 
Leu Trp Ala Ile Val Thr Val Phe Gln Ile Leu Thr Gln Glu Asp Trp
                965                 970                 975     
Asn Val Val Leu Tyr Asn Gly Met Ala Ser Thr Ser Ser Trp Ala Ala
            980                 985                 990         
Leu Tyr Phe Val Ala Leu Met Thr Phe Gly Asn Tyr Val Leu Phe Asn
        995                 1000                1005            
Leu Leu Val Ala Ile Leu Val Glu Gly Phe Gln Ala Glu Gly Asp Ala
    1010                1015                1020                
Asn Arg Ser Asp Thr Asp Glu Asp Lys Thr Ser Val His Phe Glu Glu
1025                1030                1035                1040
Asp Phe His Lys Leu Arg Glu Leu Gln Thr Thr Glu Leu Lys Met Cys
                1045                1050                1055    
Ser Leu Ala Val Thr Pro Asn Gly His Leu Glu Gly Arg Gly Ser Leu
            1060                1065                1070        
Ser Pro Pro Leu Ile Met Cys Thr Ala Ala Thr Pro Met Pro Thr Pro
        1075                1080                1085            
Lys Ser Ser Pro Phe Leu Asp Ala Ala Pro Ser Leu Pro Asp Ser Arg
    1090                1095                1100                
Arg Gly Ser Ser Ser Ser Gly Asp Pro Pro Leu Gly Asp Gln Lys Pro
1105                1110                1115                1120
Pro Ala Ser Leu Arg Ser Ser Pro Cys Ala Pro Trp Gly Pro Ser Gly
                1125                1130                1135    
Ala Trp Ser Ser Arg Arg Ser Ser Trp Ser Ser Leu Gly Arg Ala Pro
            1140                1145                1150        
Ser Leu Lys Arg Arg Gly Gln Cys Gly Glu Arg Glu Ser Leu Leu Ser
        1155                1160                1165            
Gly Glu Gly Lys Gly Ser Thr Asp Asp Glu Ala Glu Asp Gly Arg Ala
    1170                1175                1180                
Ala Pro Gly Pro Arg Ala Thr Pro Leu Arg Arg Ala Glu Ser Leu Asp
1185                1190                1195                1200
Pro Arg Pro Leu Arg Pro Ala Ala Leu Pro Pro Thr Lys Cys Arg Asp
                1205                1210                1215    
Arg Asp Gly Gln Val Val Ala Leu Pro Ser Asp Phe Phe Leu Arg Ile
            1220                1225                1230        
Asp Ser His Arg Glu Asp Ala Ala Glu Leu Asp Asp Asp Ser Glu Asp
        1235                1240                1245            
Ser Cys Cys Leu Arg Leu His Lys Val Leu Glu Pro Tyr Lys Pro Gln
    1250                1255                1260                
Trp Cys Arg Ser Arg Glu Ala Trp Ala Leu Tyr Leu Phe Ser Pro Gln
1265                1270                1275                1280
Asn Arg Phe Arg Val Ser Cys Gln Lys Val Ile Thr His Lys Met Phe
                1285                1290                1295    
Asp His Val Val Leu Val Phe Ile Phe Leu Asn Cys Val Thr Ile Ala
            1300                1305                1310        
Leu Glu Arg Pro Asp Ile Asp Pro Gly Ser Thr Glu Arg Val Phe Leu
        1315                1320                1325            
Ser Val Ser Asn Tyr Ile Phe Thr Ala Ile Phe Val Ala Glu Met Met
    1330                1335                1340                
Val Lys Val Val Ala Leu Gly Leu Leu Ser Gly Glu His Ala Tyr Leu
1345                1350                1355                1360
Gln Ser Ser Trp Asn Leu Leu Asp Gly Leu Leu Val Leu Val Ser Leu
                1365                1370                1375    
Val Asp Ile Val Val Ala Met Ala Ser Ala Gly Gly Ala Lys Ile Leu
            1380                1385                1390        
Gly Val Leu Arg Val Leu Arg Leu Leu Arg Thr Leu Arg Pro Leu Arg
        1395                1400                1405            
Val Ile Ser Arg Ala Pro Gly Leu Lys Leu Val Val Glu Thr Leu Ile
    1410                1415                1420                
Ser Ser Leu Arg Pro Ile Gly Asn Ile Val Leu Ile Cys Cys Ala Phe
1425                1430                1435                1440
Phe Ile Ile Phe Gly Ile Leu Gly Val Gln Leu Phe Lys Gly Lys Phe
                1445                1450                1455    
Tyr Tyr Cys Glu Gly Pro Asp Thr Arg Asn Ile Ser Thr Lys Ala Gln
            1460                1465                1470        
Cys Arg Ala Ala His Tyr Arg Trp Val Arg Arg Lys Tyr Asn Phe Asp
        1475                1480                1485            
Asn Leu Gly Gln Ala Leu Met Ser Leu Phe Val Leu Ser Ser Lys Asp
    1490                1495                1500                
Gly Trp Val Asn Ile Met Tyr Asp Gly Leu Asp Ala Val Gly Val Asp
1505                1510                1515                1520
Gln Gln Pro Val Gln Asn His Asn Pro Trp Met Leu Leu Tyr Phe Ile
                1525                1530                1535    
Ser Phe Leu Leu Ile Val Ser Phe Phe Val Leu Asn Met Phe Val Gly
            1540                1545                1550        
Val Val Val Glu Asn Phe His Lys Cys Arg Gln His Gln Glu Ala Glu
        1555                1560                1565            
Glu Ala Arg Arg Arg Glu Glu Lys Arg Leu Arg Arg Leu Glu Arg Arg
    1570                1575                1580                
Arg Arg Ser Thr Phe Pro Ser Pro Glu Ala Gln Arg Arg Pro Tyr Tyr
1585                1590                1595                1600
Ala Asp Tyr Ser Pro Thr Arg Arg Ser Ile His Ser Leu Cys Thr Ser
                1605                1610                1615    
His Tyr Leu Asp Leu Phe Ile Thr Phe Ile Ile Cys Val Asn Val Ile
            1620                1625                1630        
Thr Met Ser Met Glu His Tyr Asn Gln Pro Lys Ser Leu Asp Glu Ala
        1635                1640                1645            
Leu Lys Tyr Cys Asn Tyr Val Phe Thr Ile Val Phe Val Phe Glu Ala
    1650                1655                1660                
Ala Leu Lys Leu Val Ala Phe Gly Phe Arg Arg Phe Phe Lys Asp Arg
1665                1670                1675                1680
Trp Asn Gln Leu Asp Leu Ala Ile Val Leu Leu Ser Leu Met Gly Ile
                1685                1690                1695    
Thr Leu Glu Glu Ile Glu Met Ser Ala Ala Leu Pro Ile Asn Pro Thr
            1700                1705                1710        
Ile Ile Arg Ile Met Arg Val Leu Arg Ile Ala Arg Val Leu Lys Leu
        1715                1720                1725            
Leu Lys Met Ala Thr Gly Met Arg Ala Leu Leu Asp Thr Val Val Gln
    1730                1735                1740                
Ala Leu Pro Gln Val Gly Asn Leu Gly Leu Leu Phe Met Leu Leu Phe
1745                1750                1755                1760
Phe Ile Tyr Ala Ala Leu Gly Val Glu Leu Phe Gly Arg Leu Glu Cys
                1765                1770                1775    
Ser Glu Asp Asn Pro Cys Glu Gly Leu Ser Arg His Ala Thr Phe Ser
            1780                1785                1790        
Asn Phe Gly Met Ala Phe Leu Thr Leu Phe Arg Val Ser Thr Gly Asp
        1795                1800                1805            
Asn Trp Asn Gly Ile Met Lys Asp Thr Leu Arg Glu Cys Ser Arg Glu
    1810                1815                1820                
Asp Lys His Cys Leu Ser Tyr Leu Pro Ala Leu Ser Pro Val Tyr Phe
1825                1830                1835                1840
Val Thr Phe Val Leu Val Ala Gln Phe Val Leu Val Asn Val Val Val
                1845                1850                1855    
Ala Val Leu Met Lys His Leu Glu Glu Ser Asn Lys Glu Ala Arg Glu
            1860                1865                1870        
Asp Ala Glu Leu Asp Ala Glu Ile Glu Leu Glu Met Ala Gln Gly Pro
        1875                1880                1885            
Gly Ser Ala Arg Arg Val Asp Ala Asp Arg Pro Pro Leu Pro Gln Glu
    1890                1895                1900                
Ser Pro Gly Ala Arg Asp Ala Pro Asn Leu Val Ala Arg Lys Val Ser
1905                1910                1915                1920
Val Ser Arg Met Leu Ser Leu Pro Asn Asp Ser Tyr Met Phe Arg Pro
                1925                1930                1935    
Val Val Pro Ala Ser Ala Pro His Pro Arg Pro Leu Gln Glu Val Glu
            1940                1945                1950        
Met Glu Thr Tyr Gly Ala Gly Thr Pro Leu Gly Ser Val Ala Ser Val
        1955                1960                1965            
His Ser Pro Pro Ala Glu Ser Cys Ala Ser Leu Gln Ile Pro Leu Ala
    1970                1975                1980                
Val Ser Ser Pro Ala Arg Ser Gly Glu Pro Leu His Ala Leu Ser Pro
1985                1990                1995                2000
Arg Gly Thr Ala Arg Ser Pro Ser Leu Ser Arg Leu Leu Cys Arg Gln
                2005                2010                2015    
Glu Ala Val His Thr Asp Ser Leu Glu Gly Lys Ile Asp Ser Pro Arg
            2020                2025                2030        
Asp Thr Leu Asp Pro Ala Glu Pro Gly Glu Lys Thr Pro Val Arg Pro
        2035                2040                2045            
Val Thr Gln Gly Gly Ser Leu Gln Ser Pro Pro Arg Ser Pro Arg Pro
    2050                2055                2060                
Ala Ser Val Arg Thr Arg Lys His Thr Phe Gly Gln His Cys Val Ser
2065                2070                2075                2080
Ser Arg Pro Ala Ala Pro Gly Gly Glu Glu Ala Glu Ala Ser Asp Pro
                2085                2090                2095    
Ala Asp Glu Glu Val Ser His Ile Thr Ser Ser Ala Cys Pro Trp Gln
            2100                2105                2110        
Pro Thr Ala Glu Pro His Gly Pro Glu Ala Ser Pro Val Ala Gly Gly
        2115                2120                2125            
Glu Arg Asp Leu Arg Arg Leu Tyr Ser Val Asp Ala Gln Gly Phe Leu
    2130                2135                2140                
Asp Lys Pro Gly Arg Ala Asp Glu Gln Trp Arg Pro Ser Ala Glu Leu
2145                2150                2155                2160
Gly Ser Gly Glu Pro Gly Glu Ala Lys Ala Trp Gly Pro Glu Ala Glu
                2165                2170                2175    
Pro Ala Leu Gly Ala Arg Arg Lys Lys Lys Met Ser Pro Pro Cys Ile
            2180                2185                2190        
Ser Val Glu Pro Pro Ala Glu Asp Glu Gly Ser Ala Arg Pro Ser Ala
        2195                2200                2205            
Ala Glu Gly Gly Ser Thr Thr Leu Arg Arg Arg Thr Pro Ser Cys Glu
    2210                2215                2220                
Ala Thr Pro His Arg Asp Ser Leu Glu Pro Thr Glu Gly Ser Gly Ala
2225                2230                2235                2240
Gly Gly Asp Pro Ala Ala Lys Gly Glu Arg Trp Gly Gln Ala Ser Cys
                2245                2250                2255    
Arg Ala Glu His Leu Thr Val Pro Ser Phe Ala Phe Glu Pro Leu Asp
            2260                2265                2270        
Leu Gly Val Pro Ser Gly Asp Pro Phe Leu Asp Gly Ser His Ser Val
        2275                2280                2285            
Thr Pro Glu Ser Arg Ala Ser Ser Ser Gly Ala Ile Val Pro Leu Glu
    2290                2295                2300                
Pro Pro Glu Ser Glu Pro Pro Met Pro Val Gly Asp Pro Pro Glu Lys
2305                2310                2315                2320
Arg Arg Gly Leu Tyr Leu Thr Val Pro Gln Cys Pro Leu Glu Lys Pro
                2325                2330                2335    
Gly Ser Pro Ser Ala Thr Pro Ala Pro Gly Gly Gly Ala Asp Asp Pro
            2340                2345                2350        
Val
    


<210> 1129
<211> 1150
<212> PRT
<213> Homo sapiens

<400> 1129
Met Ser Lys Thr Leu Lys Lys Lys Lys His Trp Leu Ser Lys Val Gln
 1               5                  10                  15      
Glu Cys Ala Val Ser Trp Ala Gly Pro Pro Gly Asp Phe Gly Ala Glu
            20                  25                  30          
Ile Arg Gly Gly Ala Glu Arg Gly Glu Phe Pro Tyr Leu Gly Arg Leu
        35                  40                  45              
Arg Glu Glu Pro Gly Gly Gly Thr Cys Cys Ile Val Ser Gly Lys Ala
    50                  55                  60                  
Pro Asn Pro Ser Asp Val Leu Leu Glu Val Asn Gly Thr Pro Val Ser
65                  70                  75                  80  
Gly Leu Thr Asn Arg Asp Thr Leu Ala Val Ile Arg His Phe Arg Glu
                85                  90                  95      
Pro Ile Arg Leu Lys Thr Val Lys Pro Gly Lys Val Ile Asn Lys Asp
            100                 105                 110         
Leu Arg His Tyr Leu Ser Leu Gln Phe Gln Lys Gly Ser Ile Asp His
        115                 120                 125             
Lys Leu Gln Gln Val Ile Arg Asp Asn Leu Tyr Leu Arg Thr Ile Pro
    130                 135                 140                 
Cys Thr Thr Arg Ala Pro Arg Asp Gly Glu Val Pro Gly Val Asp Tyr
145                 150                 155                 160 
Asn Phe Ile Ser Val Glu Gln Phe Lys Ala Leu Glu Glu Ser Gly Ala
                165                 170                 175     
Leu Leu Glu Ser Gly Thr Tyr Asp Gly Asn Phe Tyr Gly Thr Pro Lys
            180                 185                 190         
Pro Pro Ala Glu Pro Ser Pro Phe Gln Pro Asp Pro Val Asp Gln Val
        195                 200                 205             
Leu Phe Asp Asn Glu Phe Asp Ala Glu Ser Gln Arg Lys Arg Thr Thr
    210                 215                 220                 
Ser Val Ser Lys Met Glu Arg Met Asp Ser Ser Leu Pro Glu Glu Glu
225                 230                 235                 240 
Glu Asp Glu Asp Lys Gly Ala Ile Asn Gly Ser Gly Asn Ala Glu Asn
                245                 250                 255     
Arg Glu Arg His Ser Glu Ser Ser Asp Trp Met Lys Thr Val Pro Ser
            260                 265                 270         
Tyr Asn Gln Thr Asn Ser Ser Met Asp Phe Arg Asn Tyr Met Met Arg
        275                 280                 285             
Asp Glu Thr Leu Glu Pro Leu Pro Lys Asn Trp Glu Met Ala Tyr Thr
    290                 295                 300                 
Asp Thr Gly Met Ile Tyr Phe Ile Asp His Asn Thr Lys Thr Thr Thr
305                 310                 315                 320 
Trp Leu Asp Pro Arg Leu Cys Lys Lys Ala Lys Ala Pro Glu Asp Cys
                325                 330                 335     
Glu Asp Gly Glu Leu Pro Tyr Gly Trp Glu Lys Ile Glu Asp Pro Gln
            340                 345                 350         
Tyr Gly Thr Tyr Tyr Val Asp Phe Thr Leu Val Ala Gln Ala Gly Val
        355                 360                 365             
Gln Trp His Asp Leu Gly Ser Leu Gln Pro Pro Pro Pro Gly Phe Asn
    370                 375                 380                 
His Leu Asn Gln Lys Thr Gln Phe Glu Asn Pro Val Glu Glu Ala Lys
385                 390                 395                 400 
Arg Lys Lys Gln Leu Gly Gln Val Glu Ile Gly Ser Ser Lys Pro Asp
                405                 410                 415     
Met Glu Lys Ser His Phe Thr Arg Asp Pro Ser Gln Leu Lys Gly Val
            420                 425                 430         
Leu Val Arg Ala Ser Leu Lys Lys Ser Thr Met Gly Phe Gly Phe Thr
        435                 440                 445             
Ile Ile Gly Gly Asp Arg Pro Asp Glu Phe Leu Gln Val Lys Asn Val
    450                 455                 460                 
Leu Lys Asp Gly Pro Ala Ala Gln Asp Gly Lys Ile Ala Pro Gly Asp
465                 470                 475                 480 
Val Ile Val Asp Ile Asn Gly Asn Cys Val Phe Gly His Thr His Ala
                485                 490                 495     
Asp Val Val Gln Met Phe Gln Leu Val Pro Val Asn Gln Tyr Val Asn
            500                 505                 510         
Leu Thr Leu Cys Arg Gly Tyr Pro Leu Pro Asp Asp Ser Glu Asp Pro
        515                 520                 525             
Val Val Asp Ile Val Ala Ala Thr Pro Val Ile Asn Gly Gln Ser Leu
    530                 535                 540                 
Thr Lys Gly Glu Thr Cys Met Asn Pro Gln Asp Phe Lys Pro Gly Ala
545                 550                 555                 560 
Met Val Leu Glu Gln Asn Gly Lys Ser Gly His Thr Ser Thr Gly Asp
                565                 570                 575     
Gly Leu Asn Gly Pro Ser Asp Ala Ser Glu Gln Arg Val Ser Met Ala
            580                 585                 590         
Ser Ser Gly Ser Ser Gln Pro Glu Leu Val Thr Ile Pro Leu Ile Lys
        595                 600                 605             
Gly Pro Lys Gly Phe Gly Phe Ala Ile Ala Asp Ser Pro Thr Gly Gln
    610                 615                 620                 
Lys Val Lys Met Ile Leu Asp Ser Gln Trp Cys Gln Gly Leu Gln Lys
625                 630                 635                 640 
Glu Asp Ile Ile Lys Glu Ile Tyr His Gln Asn Val Gln Asn Leu Thr
                645                 650                 655     
His Leu Gln Val Val Glu Val Leu Lys Gln Phe Pro Val Gly Ala Asp
            660                 665                 670         
Val Pro Leu Leu Ile Leu Arg Gly Gly Pro Pro Ser Thr Thr Lys Thr
        675                 680                 685             
Ala Lys Met Lys Thr Asp Lys Lys Glu Asn Ala Gly Ser Leu Glu Ala
    690                 695                 700                 
Ile Asn Glu Pro Ile Pro Gln Pro Met Pro Phe Pro Pro Ser Ile Ile
705                 710                 715                 720 
Arg Ser Gly Ser Pro Lys Leu Asp Pro Ser Glu Val Tyr Leu Lys Ser
                725                 730                 735     
Lys Thr Leu Tyr Glu Asp Lys Pro Pro Asn Thr Lys Asp Leu Asp Val
            740                 745                 750         
Phe Leu Arg Lys Gln Glu Ser Gly Phe Gly Phe Arg Val Leu Gly Gly
        755                 760                 765             
Asp Gly Pro Asp Gln Ser Ile Tyr Ile Gly Ala Ile Ile Pro Leu Gly
    770                 775                 780                 
Ala Ala Glu Lys Asp Gly Arg Leu Arg Ala Ala Asp Glu Leu Met Cys
785                 790                 795                 800 
Ile Asp Gly Ile Pro Val Lys Gly Lys Ser His Lys Gln Val Leu Asp
                805                 810                 815     
Leu Met Thr Thr Ala Ala Arg Asn Gly His Val Leu Leu Thr Val Arg
            820                 825                 830         
Arg Lys Ile Phe Tyr Gly Glu Lys Gln Pro Glu Asp Asp Ser Ser Gln
        835                 840                 845             
Ala Phe Ile Ser Thr Gln Asn Gly Ser Pro Arg Leu Asn Arg Ala Glu
    850                 855                 860                 
Val Pro Ala Arg Pro Ala Pro Gln Glu Pro Tyr Asp Val Val Leu Gln
865                 870                 875                 880 
Arg Lys Glu Asn Glu Gly Phe Gly Phe Val Ile Leu Thr Ser Lys Asn
                885                 890                 895     
Lys Pro Pro Pro Gly Val Ile Pro His Lys Ile Gly Arg Val Ile Glu
            900                 905                 910         
Gly Ser Pro Ala Asp Arg Cys Gly Lys Leu Lys Val Gly Asp His Ile
        915                 920                 925             
Ser Ala Val Asn Gly Gln Ser Ile Val Glu Leu Ser His Ala Asn Ile
    930                 935                 940                 
Val Gln Leu Ile Lys Asp Ala Gly Val Thr Val Thr Leu Thr Val Ile
945                 950                 955                 960 
Ala Glu Glu Glu His His Gly Pro Pro Ser Gly Thr Asn Ser Ala Arg
                965                 970                 975     
Gln Ser Pro Ala Leu Gln His Arg Pro Met Gly Gln Ser Gln Ala Asn
            980                 985                 990         
His Ile Pro Gly Asp Arg Ser Ala Leu Glu Gly Glu Ile Gly Lys Asp
        995                 1000                1005            
Val Ser Thr Ser Tyr Arg His Ser Trp Ser Asp His Lys His Leu Ala
    1010                1015                1020                
Gln Pro Asp Thr Ala Val Ile Ser Val Val Gly Ser Arg His Asn Gln
1025                1030                1035                1040
Asn Leu Gly Cys Tyr Pro Val Glu Leu Glu Arg Gly Pro Arg Gly Phe
                1045                1050                1055    
Gly Phe Ser Leu Arg Gly Gly Lys Glu Tyr Asn Met Gly Leu Phe Ile
            1060                1065                1070        
Leu Arg Leu Ala Glu Asp Gly Pro Ala Ile Lys Asp Gly Arg Ile His
        1075                1080                1085            
Val Gly Asp Gln Ile Val Glu Ile Asn Gly Glu Pro Thr Gln Gly Ile
    1090                1095                1100                
Thr His Thr Arg Ala Ile Glu Leu Ile Gln Ala Gly Gly Asn Lys Val
1105                1110                1115                1120
Leu Leu Leu Leu Arg Pro Gly Thr Gly Leu Ile Pro Asp His Gly Leu
                1125                1130                1135    
Ala Pro Ser Gly Leu Cys Ser Tyr Val Lys Pro Glu Gln His
            1140                1145                1150


<210> 1130
<211> 747
<212> PRT
<213> Homo sapiens

<400> 1130
Met Ser Gln Val Lys Ser Ser Tyr Ser Tyr Asp Ala Pro Ser Asp Phe
 1               5                  10                  15      
Ile Asn Phe Ser Ser Leu Asp Asp Glu Gly Asp Thr Gln Asn Ile Asp
            20                  25                  30          
Ser Trp Phe Glu Glu Lys Ala Asn Leu Glu Asn Lys Leu Leu Gly Lys
        35                  40                  45              
Asn Gly Thr Gly Gly Leu Phe Gln Gly Lys Thr Pro Leu Arg Lys Ala
    50                  55                  60                  
Asn Leu Gln Gln Ala Ile Val Thr Pro Leu Lys Pro Val Asp Asn Thr
65                  70                  75                  80  
Tyr Tyr Lys Glu Ala Glu Lys Glu Asn Leu Val Glu Gln Ser Ile Pro
                85                  90                  95      
Ser Asn Ala Cys Ser Ser Leu Glu Val Glu Ala Ala Ile Ser Arg Lys
            100                 105                 110         
Thr Pro Ala Gln Pro Gln Arg Arg Ser Leu Arg Leu Ser Ala Gln Lys
        115                 120                 125             
Asp Leu Glu Gln Lys Glu Lys His His Val Lys Met Lys Ala Lys Arg
    130                 135                 140                 
Cys Ala Thr Pro Val Ile Ile Asp Glu Ile Leu Pro Ser Lys Lys Met
145                 150                 155                 160 
Lys Val Ser Asn Asn Lys Lys Lys Pro Glu Glu Glu Gly Ser Ala His
                165                 170                 175     
Gln Asp Thr Ala Glu Lys Asn Ala Ser Ser Pro Glu Lys Ala Lys Gly
            180                 185                 190         
Arg His Thr Val Pro Cys Met Pro Pro Ala Lys Gln Lys Phe Leu Lys
        195                 200                 205             
Ser Thr Glu Glu Gln Glu Leu Glu Lys Ser Met Lys Met Gln Gln Glu
    210                 215                 220                 
Val Val Glu Met Arg Lys Lys Asn Glu Glu Phe Lys Lys Leu Ala Leu
225                 230                 235                 240 
Ala Gly Ile Gly Gln Pro Val Lys Lys Ser Val Ser Gln Val Thr Lys
                245                 250                 255     
Ser Val Asp Phe His Phe Arg Thr Asp Glu Arg Ile Lys Gln His Pro
            260                 265                 270         
Glu Asn Gln Glu Glu Tyr Lys Glu Val Asn Phe Thr Ser Glu Leu Arg
        275                 280                 285             
Lys His Pro Ser Ser Pro Ala Arg Val Thr Lys Gly Cys Thr Ile Val
    290                 295                 300                 
Lys Pro Phe Asn Leu Ser Gln Gly Lys Lys Arg Thr Phe Asp Glu Thr
305                 310                 315                 320 
Val Ser Thr Tyr Val Pro Leu Ala Gln Gln Val Glu Asp Phe His Lys
                325                 330                 335     
Arg Thr Pro Asn Arg Tyr His Leu Arg Ser Lys Lys Asp Asp Ile Asn
            340                 345                 350         
Leu Leu Pro Ser Lys Ser Ser Val Thr Lys Ile Cys Arg Asp Pro Gln
        355                 360                 365             
Thr Pro Val Leu Gln Thr Lys His Arg Ala Arg Ala Val Thr Cys Lys
    370                 375                 380                 
Ser Thr Ala Glu Leu Glu Ala Glu Glu Leu Glu Lys Leu Gln Gln Tyr
385                 390                 395                 400 
Lys Phe Lys Ala Arg Glu Leu Asp Pro Arg Ile Leu Glu Gly Gly Pro
                405                 410                 415     
Ile Leu Pro Lys Lys Pro Pro Val Lys Pro Pro Thr Glu Pro Ile Gly
            420                 425                 430         
Phe Asp Leu Glu Ile Glu Lys Arg Ile Gln Glu Arg Glu Ser Lys Lys
        435                 440                 445             
Lys Thr Glu Asp Glu His Phe Glu Phe His Ser Arg Pro Cys Pro Thr
    450                 455                 460                 
Lys Ile Leu Glu Asp Val Val Gly Val Pro Glu Lys Lys Val Leu Pro
465                 470                 475                 480 
Ile Thr Val Pro Lys Ser Pro Ala Phe Ala Leu Lys Asn Arg Ile Arg
                485                 490                 495     
Met Pro Thr Lys Glu Asp Glu Glu Glu Asp Glu Pro Val Val Ile Lys
            500                 505                 510         
Ala Gln Pro Val Pro His Tyr Gly Val Pro Phe Lys Pro Gln Ile Pro
        515                 520                 525             
Glu Ala Arg Thr Val Glu Ile Cys Pro Phe Ser Phe Asp Ser Arg Asp
    530                 535                 540                 
Lys Glu Arg Gln Leu Gln Lys Glu Lys Lys Ile Lys Glu Leu Gln Lys
545                 550                 555                 560 
Gly Glu Val Pro Lys Phe Lys Ala Leu Pro Leu Pro His Phe Asp Thr
                565                 570                 575     
Ile Asn Leu Pro Glu Lys Lys Val Lys Asn Val Thr Gln Ile Glu Pro
            580                 585                 590         
Phe Cys Leu Glu Thr Asp Arg Arg Gly Ala Leu Lys Ala Gln Thr Trp
        595                 600                 605             
Lys His Gln Leu Glu Glu Glu Leu Arg Gln Gln Lys Glu Ala Ala Cys
    610                 615                 620                 
Phe Lys Ala Arg Pro Asn Thr Val Ile Ser Gln Glu Pro Phe Val Pro
625                 630                 635                 640 
Lys Lys Glu Lys Lys Ser Val Ala Glu Gly Leu Ser Gly Ser Leu Val
                645                 650                 655     
Gln Glu Pro Phe Gln Leu Ala Thr Glu Lys Arg Ala Lys Glu Arg Gln
            660                 665                 670         
Glu Leu Glu Lys Arg Met Ala Glu Val Glu Ala Gln Lys Ala Gln Gln
        675                 680                 685             
Leu Glu Glu Ala Arg Leu Gln Glu Glu Glu Gln Lys Lys Glu Glu Leu
    690                 695                 700                 
Ala Arg Leu Arg Arg Glu Leu Val His Lys Ala Asn Pro Ile Arg Lys
705                 710                 715                 720 
Tyr Gln Gly Leu Glu Ile Lys Ser Ser Asp Gln Pro Leu Thr Val Pro
                725                 730                 735     
Val Ser Pro Lys Phe Ser Thr Arg Phe His Cys
            740                 745         


<210> 1131
<211> 229
<212> PRT
<213> Homo sapiens

<400> 1131
Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu
 1               5                  10                  15      
Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp
            20                  25                  30          
Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys
        35                  40                  45              
Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu
    50                  55                  60                  
Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly Met Gln Ile Phe
65                  70                  75                  80  
Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser
                85                  90                  95      
Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile
            100                 105                 110         
Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp
        115                 120                 125             
Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His
    130                 135                 140                 
Leu Val Leu Arg Leu Arg Gly Gly Met Gln Ile Phe Val Lys Thr Leu
145                 150                 155                 160 
Thr Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu
                165                 170                 175     
Asn Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln
            180                 185                 190         
Gln Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu
        195                 200                 205             
Ser Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His Leu Val Leu Arg
    210                 215                 220                 
Leu Arg Gly Gly Cys
225                 


<210> 1132
<211> 198
<212> PRT
<213> Homo sapiens

<400> 1132
Met Ala Thr Leu Trp Gly Gly Leu Leu Arg Leu Gly Ser Leu Leu Ser
 1               5                  10                  15      
Leu Ser Cys Leu Ala Leu Ser Val Leu Leu Leu Ala Gln Leu Ser Asp
            20                  25                  30          
Ala Ala Lys Asn Phe Glu Asp Val Arg Cys Lys Cys Ile Cys Pro Pro
        35                  40                  45              
Tyr Lys Glu Asn Ser Gly His Ile Tyr Asn Lys Asn Ile Ser Gln Lys
    50                  55                  60                  
Asp Cys Asp Cys Leu His Val Val Glu Pro Met Pro Val Arg Gly Pro
65                  70                  75                  80  
Asp Val Glu Ala Tyr Cys Leu Arg Cys Glu Cys Lys Tyr Glu Glu Arg
                85                  90                  95      
Ser Ser Val Thr Ile Lys Val Thr Ile Ile Ile Tyr Leu Ser Ile Leu
            100                 105                 110         
Gly Leu Leu Leu Leu Tyr Met Val Tyr Leu Thr Leu Val Glu Pro Ile
        115                 120                 125             
Leu Lys Arg Arg Leu Phe Gly His Ala Gln Leu Ile Gln Ser Asp Asp
    130                 135                 140                 
Asp Ile Gly Asp His Gln Pro Phe Ala Asn Ala His Asp Val Leu Ala
145                 150                 155                 160 
Arg Ser Arg Ser Arg Ala Asn Val Leu Asn Lys Val Glu Tyr Ala Gln
                165                 170                 175     
Gln Arg Trp Lys Leu Gln Val Gln Glu Gln Arg Lys Ser Val Phe Asp
            180                 185                 190         
Arg His Val Val Leu Ser
        195             


<210> 1133
<211> 229
<212> PRT
<213> Homo sapiens

<400> 1133
Met Ala Arg Leu Ala Leu Ser Pro Val Pro Ser His Trp Met Val Ala
 1               5                  10                  15      
Leu Leu Leu Leu Leu Ser Ala Glu Pro Val Pro Ala Ala Arg Ser Glu
            20                  25                  30          
Asp Arg Tyr Arg Asn Pro Lys Gly Ser Ala Cys Ser Arg Ile Trp Gln
        35                  40                  45              
Ser Pro Arg Phe Ile Ala Arg Lys Arg Gly Phe Thr Val Lys Met His
    50                  55                  60                  
Cys Tyr Met Asn Ser Ala Ser Gly Asn Val Ser Trp Leu Trp Lys Gln
65                  70                  75                  80  
Glu Met Asp Glu Asn Pro Gln Gln Leu Lys Leu Glu Lys Gly Arg Met
                85                  90                  95      
Glu Glu Ser Gln Asn Glu Ser Leu Ala Thr Leu Thr Ile Gln Gly Ile
            100                 105                 110         
Arg Phe Glu Asp Asn Gly Ile Tyr Phe Cys Gln Gln Lys Cys Asn Asn
        115                 120                 125             
Thr Ser Glu Val Tyr Gln Gly Cys Gly Thr Glu Leu Arg Val Met Gly
    130                 135                 140                 
Phe Ser Thr Leu Ala Gln Leu Lys Gln Arg Asn Thr Leu Lys Asp Gly
145                 150                 155                 160 
Ile Ile Met Ile Gln Thr Leu Leu Ile Ile Leu Phe Ile Ile Val Pro
                165                 170                 175     
Ile Phe Leu Leu Leu Asp Lys Asp Asp Ser Lys Ala Gly Met Glu Glu
            180                 185                 190         
Asp His Thr Tyr Glu Gly Leu Asp Ile Asp Gln Thr Ala Thr Tyr Glu
        195                 200                 205             
Asp Ile Val Thr Leu Arg Thr Gly Glu Val Lys Trp Ser Val Gly Glu
    210                 215                 220                 
His Pro Gly Gln Glu
225                 


<210> 1134
<211> 340
<212> PRT
<213> Homo sapiens

<400> 1134
Met Ser Glu Leu Glu Gln Leu Arg Gln Glu Ala Glu Gln Leu Arg Asn
 1               5                  10                  15      
Gln Ile Gln Asp Ala Arg Lys Ala Cys Asn Asp Ala Thr Leu Val Gln
            20                  25                  30          
Ile Thr Ser Asn Met Asp Ser Val Gly Arg Ile Gln Met Arg Thr Arg
        35                  40                  45              
Arg Thr Leu Arg Gly His Leu Ala Lys Ile Tyr Ala Met His Trp Gly
    50                  55                  60                  
Tyr Asp Ser Arg Leu Leu Val Ser Ala Ser Gln Asp Gly Lys Leu Ile
65                  70                  75                  80  
Ile Trp Asp Ser Tyr Thr Thr Asn Lys Met His Ala Ile Pro Leu Arg
                85                  90                  95      
Ser Ser Trp Val Met Thr Cys Ala Tyr Ala Pro Ser Gly Asn Tyr Val
            100                 105                 110         
Ala Cys Gly Gly Leu Asp Asn Ile Cys Ser Ile Tyr Asn Leu Lys Thr
        115                 120                 125             
Arg Glu Gly Asn Val Arg Val Ser Arg Glu Leu Pro Gly His Thr Gly
    130                 135                 140                 
Tyr Leu Ser Cys Cys Arg Phe Leu Asp Asp Ser Gln Ile Val Thr Ser
145                 150                 155                 160 
Ser Gly Asp Thr Thr Cys Ala Leu Trp Asp Ile Glu Thr Ala Gln Gln
                165                 170                 175     
Thr Thr Thr Phe Thr Gly His Ser Gly Asp Val Met Ser Leu Ser Leu
            180                 185                 190         
Ser Pro Asp Met Arg Thr Phe Val Ser Gly Ala Cys Asp Ala Ser Ser
        195                 200                 205             
Lys Leu Trp Asp Ile Arg Asp Gly Met Cys Arg Gln Ser Phe Thr Gly
    210                 215                 220                 
His Val Ser Asp Ile Asn Ala Val Ser Phe Phe Pro Asn Gly Tyr Ala
225                 230                 235                 240 
Phe Ala Thr Gly Ser Asp Asp Ala Thr Cys Arg Leu Phe Asp Leu Arg
                245                 250                 255     
Ala Asp Gln Glu Leu Leu Leu Tyr Ser His Asp Asn Ile Ile Cys Gly
            260                 265                 270         
Ile Thr Ser Val Ala Phe Ser Lys Ser Gly Arg Leu Leu Leu Ala Gly
        275                 280                 285             
Tyr Asp Asp Phe Asn Cys Asn Val Trp Asp Thr Leu Lys Gly Asp Arg
    290                 295                 300                 
Ala Gly Val Leu Ala Gly His Asp Asn Arg Val Ser Cys Leu Gly Val
305                 310                 315                 320 
Thr Asp Asp Gly Met Ala Val Ala Thr Gly Ser Trp Asp Ser Phe Leu
                325                 330                 335     
Arg Ile Trp Asn
            340 


<210> 1135
<211> 932
<212> PRT
<213> Homo sapiens

<400> 1135
Met Ala Ala Leu Gln Lys Leu Pro His Cys Arg Lys Leu Val Leu Leu
 1               5                  10                  15      
Cys Phe Leu Leu Ala Thr Leu Trp Glu Ala Arg Ala Gly Gln Ile Arg
            20                  25                  30          
Tyr Ser Val Arg Glu Glu Ile Asp Arg Gly Ser Phe Val Gly Asn Ile
        35                  40                  45              
Ala Lys Asp Leu Gly Leu Glu Pro Leu Ala Leu Ala Glu Gln Gly Val
    50                  55                  60                  
Arg Ile Val Ser Arg Gly Arg Ser Gln Leu Phe Ala Leu Asn Pro Arg
65                  70                  75                  80  
Ser Gly Ser Leu Val Thr Ala Asn Arg Ile Asp Arg Glu Glu Leu Cys
                85                  90                  95      
Ala Gln Ser Ala Pro Cys Leu Leu Asn Phe Asn Ile Leu Leu Glu Asp
            100                 105                 110         
Lys Leu Thr Ile Tyr Ser Val Glu Val Glu Ile Thr Asp Ile Asn Asp
        115                 120                 125             
Asn Ala Pro Arg Phe Gly Val Glu Glu Leu Glu Leu Lys Ile Ser Glu
    130                 135                 140                 
Thr Thr Thr Pro Gly Phe Arg Ile Pro Leu Lys Asn Ala His Asp Ala
145                 150                 155                 160 
Asp Val Gly Glu Asn Ala Leu Gln Lys Tyr Ala Leu Asn Pro Asn Asp
                165                 170                 175     
His Phe Ser Leu Asp Val Arg Arg Gly Ala Asp Gly Asn Lys Tyr Pro
            180                 185                 190         
Glu Leu Val Leu Glu Arg Ser Leu Asp Arg Glu Glu Glu Ala Val His
        195                 200                 205             
His Leu Val Leu Val Ala Ser Asp Gly Gly Asp Pro Val Leu Ser Gly
    210                 215                 220                 
Thr Ser Arg Ile Cys Val Lys Val Leu Asp Ala Asn Asp Asn Ala Pro
225                 230                 235                 240 
Val Phe Thr Gln Pro Glu Tyr Arg Ile Ser Ile Pro Glu Asn Thr Leu
                245                 250                 255     
Val Gly Thr Arg Ile Leu Thr Val Thr Ala Thr Asp Ala Asp Glu Gly
            260                 265                 270         
Tyr Tyr Ala Gln Val Val Tyr Phe Leu Glu Lys Ser Pro Gly Glu Thr
        275                 280                 285             
Ser Glu Val Phe Glu Leu Lys Ser Thr Ser Gly Glu Leu Thr Ile Ile
    290                 295                 300                 
Lys Asp Leu Asp Tyr Glu Asp Ala Thr Phe His Glu Ile Asp Ile Glu
305                 310                 315                 320 
Ala Gln Asp Gly Pro Gly Leu Leu Thr Arg Ala Lys Val Ile Val Thr
                325                 330                 335     
Val Leu Asp Val Asn Asp Asn Ala Pro Glu Phe Tyr Met Thr Ser Ala
            340                 345                 350         
Thr Ser Ser Val Ser Glu Asp Ser Leu Pro Gly Thr Ile Ile Gly Leu
        355                 360                 365             
Phe Asn Val His Asp Arg Asp Ser Gly Gln Asn Ala Phe Thr Thr Cys
    370                 375                 380                 
Ser Leu Pro Glu Asp Leu Pro Phe Lys Leu Glu Lys Ser Val Asp Asn
385                 390                 395                 400 
Tyr Tyr Arg Leu Val Thr Thr Arg Ala Leu Asp Arg Glu Gln Phe Ser
                405                 410                 415     
Phe Tyr Asn Ile Thr Leu Thr Ala Lys Asp Gly Gly Asn Pro Ser Leu
            420                 425                 430         
Ser Thr Asp Ala His Ile Leu Leu Gln Val Ala Asp Ile Asn Asp Asn
        435                 440                 445             
Ala Pro Ala Phe Ser Arg Thr Ser Tyr Ser Thr Tyr Ile Pro Glu Asn
    450                 455                 460                 
Asn Pro Arg Gly Ala Ser Val Phe Ser Val Thr Ala His Asp Pro Asp
465                 470                 475                 480 
Ser Asn Asp Asn Ala His Val Thr Tyr Ser Phe Ala Glu Asp Thr Val
                485                 490                 495     
Gln Gly Ala Pro Leu Ser Ser Tyr Ile Ser Ile Asn Ser Asp Thr Gly
            500                 505                 510         
Val Leu Tyr Ala Leu Arg Ser Phe Asp Tyr Glu Gln Leu Arg Asp Leu
        515                 520                 525             
Gln Val Trp Val Ile Ala Arg Asp Ser Gly Asn Pro Pro Leu Ser Ser
    530                 535                 540                 
Asn Val Ser Leu Ser Leu Phe Val Leu Asp Gln Asn Asp Asn Ala Pro
545                 550                 555                 560 
Glu Ile Leu Tyr Pro Ala Phe Pro Thr Asp Gly Ser Thr Gly Val Glu
                565                 570                 575     
Leu Ala Pro Arg Ser Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val
            580                 585                 590         
Ala Val Asp Arg Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr His Leu
        595                 600                 605             
Leu Lys Ala Ser Glu Pro Gly Leu Phe Ser Val Gly Leu His Thr Gly
    610                 615                 620                 
Glu Val Arg Thr Ala Arg Ala Leu Leu Asp Arg Asp Ala Leu Lys Gln
625                 630                 635                 640 
Ser Leu Val Val Ala Ile Gln Asp His Gly Gln Pro Pro Leu Ser Ala
                645                 650                 655     
Thr Val Thr Leu Thr Val Ala Val Ala Asp Arg Ile Pro Asp Ile Leu
            660                 665                 670         
Ala Asp Leu Gly Ser Leu Glu Pro Ser Ala Ile Pro Asn Asp Ser Asp
        675                 680                 685             
Leu Thr Leu Tyr Leu Val Val Ala Val Ala Ala Val Ser Cys Val Phe
    690                 695                 700                 
Leu Ala Phe Val Ile Val Leu Leu Ala His Arg Leu Arg Arg Trp His
705                 710                 715                 720 
Lys Ser Arg Leu Leu Gln Ala Ser Gly Gly Ser Leu Thr Gly Met Gln
                725                 730                 735     
Ser Ser His Phe Val Gly Val Asp Gly Val Arg Ala Phe Leu Gln Thr
            740                 745                 750         
Tyr Ser His Glu Val Ser Leu Thr Ala Asp Ser Arg Lys Ser His Leu
        755                 760                 765             
Ile Phe Pro Gln Pro Asn Tyr Ala Asp Thr Leu Ile Ser Gln Glu Ser
    770                 775                 780                 
Cys Glu Lys Lys Asp Phe Leu Ser Ala Pro Gln Ser Leu Leu Glu Glu
785                 790                 795                 800 
Glu Arg Glu Glu Thr Phe Ser Gln Gln Ala Pro Pro Asn Thr Asp Trp
                805                 810                 815     
Arg Phe Ser Gln Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln Asn Gly
            820                 825                 830         
Asp Asp Thr Gly Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu Met Leu
        835                 840                 845             
Gln Ala Met Ile Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly Ser Ser
    850                 855                 860                 
Thr Leu Gly Gly Gly Ala Gly Thr Met Gly Leu Ser Ala Arg Tyr Gly
865                 870                 875                 880 
Pro Gln Phe Thr Leu Gln His Val Pro Asp Tyr Arg Gln Asn Val Tyr
                885                 890                 895     
Ile Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys Arg Asp
            900                 905                 910         
Gly Lys Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser Gly Lys
        915                 920                 925             
Lys Glu Lys Lys
    930         


<210> 1136
<211> 31
<212> PRT
<213> Homo sapiens

<400> 1136
Met Val His Leu Thr Pro Glu Glu Lys Ser Ala Val Thr Ala Leu Trp
 1               5                  10                  15      
Gly Lys Val Asn Val Asp Glu Val Gly Gly Lys Ala Leu Gly Arg
            20                  25                  30      


<210> 1137
<211> 541
<212> PRT
<213> Homo sapiens

<400> 1137
Met Phe Ser Trp Met Gly Arg Gln Ala Gly Gly Arg Glu Arg Ala Gly
 1               5                  10                  15      
Gly Ala Asp Ala Val Gln Thr Val Thr Gly Gly Leu Arg Ser Leu Tyr
            20                  25                  30          
Leu Arg Lys Val Leu Pro Leu Glu Glu Ala Tyr Arg Phe His Glu Phe
        35                  40                  45              
His Ser Pro Ala Leu Glu Asp Ala Asp Phe Glu Asn Lys Pro Met Ile
    50                  55                  60                  
Leu Leu Val Gly Gln Tyr Ser Thr Gly Lys Thr Thr Phe Ile Arg Tyr
65                  70                  75                  80  
Leu Leu Glu Gln Asp Phe Pro Gly Met Arg Ile Gly Pro Glu Pro Thr
                85                  90                  95      
Thr Asp Ser Phe Ile Ala Val Met Tyr Gly Glu Thr Glu Gly Ser Thr
            100                 105                 110         
Pro Gly Asn Ala Leu Val Val Asp Pro Lys Lys Pro Phe Arg Lys Leu
        115                 120                 125             
Ser Arg Phe Gly Asn Ala Phe Leu Asn Arg Phe Met Cys Ser Gln Leu
    130                 135                 140                 
Pro Asn Gln Val Leu Lys Ser Ile Ser Val Ile Asp Ser Pro Gly Ile
145                 150                 155                 160 
Leu Ser Gly Glu Lys Gln Arg Ile Ser Arg Gly Tyr Asp Phe Cys Gln
                165                 170                 175     
Val Leu Gln Trp Phe Ala Glu Arg Val Asp Arg Ile Ile Leu Leu Phe
            180                 185                 190         
Asp Ala His Lys Leu Asp Ile Ser Asp Glu Phe Ser Glu Ala Ile Lys
        195                 200                 205             
Ala Phe Arg Gly Gln Asp Asp Lys Ile Arg Val Val Leu Asn Lys Ala
    210                 215                 220                 
Asp Gln Val Asp Thr Gln Gln Leu Met Arg Val Tyr Gly Ala Leu Met
225                 230                 235                 240 
Trp Ser Leu Gly Lys Val Ile Asn Thr Pro Glu Val Leu Arg Val Tyr
                245                 250                 255     
Ile Gly Ser Phe Trp Ala Gln Pro Leu Gln Asn Thr Asp Asn Arg Arg
            260                 265                 270         
Leu Phe Glu Ala Glu Ala Gln Asp Leu Phe Arg Asp Ile Gln Ser Leu
        275                 280                 285             
Pro Gln Lys Ala Ala Val Arg Lys Ile Asn Asp Leu Ile Lys Arg Ala
    290                 295                 300                 
Arg Leu Ala Lys Val His Ala Tyr Ile Ile Ser Tyr Leu Lys Lys Glu
305                 310                 315                 320 
Met Pro Ser Val Phe Gly Lys Glu Asn Lys Lys Arg Glu Leu Ile Ser
                325                 330                 335     
Arg Leu Pro Glu Ile Tyr Ile Gln Leu Gln Arg Glu Tyr Gln Ile Ser
            340                 345                 350         
Ala Gly Asp Phe Pro Glu Val Lys Ala Met Gln Glu Gln Leu Glu Asn
        355                 360                 365             
Tyr Asp Phe Thr Lys Phe His Ser Leu Lys Pro Lys Leu Ile Glu Ala
    370                 375                 380                 
Val Asp Asn Met Leu Ser Asn Lys Ile Ser Pro Leu Met Asn Leu Ile
385                 390                 395                 400 
Ser Gln Glu Glu Thr Ser Thr Pro Thr Gln Leu Val Gln Gly Gly Ala
                405                 410                 415     
Phe Asp Gly Thr Pro Arg Ala Pro Ser Thr Arg Ala Thr Gly Arg Val
            420                 425                 430         
Pro Lys Glu Gly Ala Asp Gln Glu Glu Trp Val Val Ala Lys Asp Lys
        435                 440                 445             
Pro Val Tyr Asp Glu Leu Phe Tyr Thr Leu Ser Pro Ile Asn Gly Lys
    450                 455                 460                 
Ile Ser Gly Val Asn Ala Lys Lys Glu Met Val Thr Ser Lys Leu Pro
465                 470                 475                 480 
Asn Ser Val Leu Gly Lys Ile Trp Lys Leu Ala Asp Cys Asp Cys Asp
                485                 490                 495     
Gly Met Leu Asp Glu Glu Glu Phe Ala Leu Ala Lys His Leu Ile Lys
            500                 505                 510         
Ile Lys Leu Asp Gly Tyr Glu Leu Pro Ser Ser Leu Pro Pro His Leu
        515                 520                 525             
Val Pro Pro Ser His Arg Lys Ser Leu Pro Lys Ala Asp
    530                 535                 540     


<210> 1138
<211> 307
<212> PRT
<213> Homo sapiens

<400> 1138
Asn Ser Arg Glu Ala Val Cys Ile Val Leu Ser Asp Asp Thr Cys Ser
 1               5                  10                  15      
Asp Glu Lys Ile Arg Met Asn Arg Val Val Arg Asn Asn Leu Arg Val
            20                  25                  30          
Arg Leu Gly Asp Val Ile Ser Ile Gln Pro Cys Pro Asp Val Lys Tyr
        35                  40                  45              
Gly Lys Arg Ile His Val Leu Pro Ile Asp Asp Thr Val Glu Gly Ile
    50                  55                  60                  
Thr Gly Asn Leu Phe Glu Val Tyr Leu Lys Pro Tyr Phe Leu Glu Ala
65                  70                  75                  80  
Tyr Arg Pro Ile Arg Lys Gly Asp Ile Phe Leu Val Arg Gly Gly Met
                85                  90                  95      
Arg Ala Val Glu Phe Lys Val Val Glu Thr Asp Pro Ser Pro Tyr Cys
            100                 105                 110         
Ile Val Ala Pro Asp Thr Val Ile His Cys Glu Gly Glu Pro Ile Lys
        115                 120                 125             
Arg Glu Asp Glu Glu Glu Ser Leu Asn Glu Val Gly Tyr Asp Asp Ile
    130                 135                 140                 
Gly Gly Cys Arg Lys Gln Leu Ala Gln Ile Lys Glu Met Val Glu Leu
145                 150                 155                 160 
Pro Leu Arg His Pro Ala Leu Phe Lys Ala Ile Gly Val Lys Pro Pro
                165                 170                 175     
Arg Gly Ile Leu Leu Tyr Gly Pro Pro Gly Thr Gly Lys Thr Leu Ile
            180                 185                 190         
Ala Arg Ala Val Ala Asn Glu Thr Gly Ala Phe Phe Phe Leu Ile Asn
        195                 200                 205             
Gly Pro Glu Ile Met Ser Lys Leu Ala Gly Glu Ser Glu Ser Asn Leu
    210                 215                 220                 
Arg Lys Ala Phe Glu Glu Ala Glu Lys Asn Ala Pro Ala Ile Ile Phe
225                 230                 235                 240 
Ile Asp Glu Leu Asp Ala Ile Ala Pro Lys Arg Glu Lys Thr His Gly
                245                 250                 255     
Glu Val Glu Arg Arg Ile Val Ser Gln Leu Leu Thr Leu Met Asp Gly
            260                 265                 270         
Leu Lys Gln Arg Ala His Val Ile Val Met Ala Ala Thr Asn Arg Pro
        275                 280                 285             
Asn Ser Ile Asp Pro Ala Leu Arg Arg Phe Gly Arg Phe Asp Arg Glu
    290                 295                 300                 
Val Asp Ile
305         


<210> 1139
<211> 1388
<212> PRT
<213> Homo sapiens

<400> 1139
Met Phe Arg Arg Ala Arg Leu Ser Val Lys Pro Asn Val Arg Pro Gly
 1               5                  10                  15      
Val Gly Ala Arg Gly Ser Thr Ala Ser Asn Pro Gln Arg Gly Arg Glu
            20                  25                  30          
Ser Pro Arg Pro Pro Glu Pro Ala Thr Asp Ser Ala Ser Lys Pro Ala
        35                  40                  45              
Glu Pro Thr Asp Val Pro Thr Val Asp Phe Gly Gly Ala Glu Pro Gln
    50                  55                  60                  
Glu Lys Ala Pro Arg Ser Ser Thr Glu Lys Thr Gly Gly Asp Asn Asp
65                  70                  75                  80  
Val Glu Glu Ser Ser Arg Ser Ser Ser Thr Val Ser Gln Arg Arg Lys
                85                  90                  95      
Arg Ile Ser Ser Thr Ser Ser Leu Val Lys Ser Ser Val Ser Val Pro
            100                 105                 110         
Ser Glu Ser His Pro Leu Ser Thr Ile Asn Gln Glu Ala Pro Gln Pro
        115                 120                 125             
Thr Ala Thr Ser Thr Lys Glu Lys Gln Pro Cys Ser Asp Arg Tyr Arg
    130                 135                 140                 
Ile Tyr Lys Ala Gln Lys Leu Arg Glu Met Leu Lys Glu Glu Leu Arg
145                 150                 155                 160 
Lys Glu Lys Lys Gln Trp Lys Asn Lys Tyr Ala Ile Asn Glu Ser Gln
                165                 170                 175     
Arg Pro Pro Asp Arg Ser Lys Met Thr Met Arg Asp Phe Ile Tyr Tyr
            180                 185                 190         
Leu Pro Asp Asn Asn Pro Met Thr Ser Ser Leu Glu Gln Glu Lys Lys
        195                 200                 205             
Thr Glu Lys Pro Ser Thr Pro Val Gln Thr Arg Glu Gln Glu Gly Lys
    210                 215                 220                 
Ser Thr Pro Asn Ala Glu Asp Asn Gly Met Glu Glu Glu Thr Asp Asp
225                 230                 235                 240 
Gly Pro Leu Leu Val Pro Arg Val Lys Val Ala Glu Asp Gly Ser Ile
                245                 250                 255     
Ile Leu Asp Glu Glu Ser Leu Thr Val Glu Val Leu Arg Thr Lys Gly
            260                 265                 270         
Pro Cys Val Val Glu Glu Asn Asp Pro Ile Phe Glu Arg Gly Ser Thr
        275                 280                 285             
Thr Thr Tyr Ser Ser Phe Arg Lys Asn Tyr Tyr Ser Lys Pro Trp Ser
    290                 295                 300                 
Asn Lys Glu Thr Asp Met Phe Phe Leu Ala Ile Ser Met Val Gly Thr
305                 310                 315                 320 
Asp Phe Ser Met Ile Gly Gln Leu Phe Pro His Arg Ala Arg Ile Glu
                325                 330                 335     
Ile Lys Asn Lys Phe Lys Arg Glu Glu Lys Thr Asn Gly Trp Arg Ile
            340                 345                 350         
Asp Lys Ala Phe Gln Glu Lys Arg Pro Phe Asp Phe Asp Phe Phe Ala
        355                 360                 365             
His Leu Leu Gln Lys Val Leu Ala Glu Glu Glu Lys Arg Lys Gln Lys
    370                 375                 380                 
Ser Val Lys Asn His Ser Leu Lys Glu Lys Lys Ser Thr Lys Pro Arg
385                 390                 395                 400 
Lys Asn Val Lys Val Lys Lys Val Ala Cys Glu Gly Val Asn Asn Asp
                405                 410                 415     
Pro Asp Glu Ser Met Ser Ser Arg Ile Ser Asp Thr Glu Arg Ser Gln
            420                 425                 430         
Lys Asp Ala Gln Thr Val Glu Glu Glu Ser Leu Thr Leu Ser Arg Glu
        435                 440                 445             
Asp Ala Glu Gln Val Ala Leu Glu Val Asp Leu Asn Gln Lys Lys Arg
    450                 455                 460                 
Arg Arg Lys Lys Gln Asp Gly Ala Asn Glu Leu Gly Val Asn Asn Leu
465                 470                 475                 480 
Leu Glu Asn Ala Thr Val Gln Ala Gly Pro Ser Lys Gly Glu Lys His
                485                 490                 495     
Lys Asn Lys Cys Gln Ala Ile Arg Pro Glu Leu Lys Glu Gly Glu Cys
            500                 505                 510         
Ser Lys Glu Gln Met Leu Ser Cys Thr Gln Asn Ile Asp Gly Ile Val
        515                 520                 525             
Gly Phe Ala Ser Thr Glu Lys Val Glu Lys Arg Thr Asp Pro Ile Leu
    530                 535                 540                 
Ser Leu Ser Asn Gln Gln Asp Ala Thr Ser Val Ala Thr Glu Ser Ser
545                 550                 555                 560 
Glu Ser Ser Thr Ser Asp Leu Pro Ser Phe Glu Val Gly Ile Arg Ala
                565                 570                 575     
Leu Cys Glu Val Asn Asn Ala Glu Gly Ser Cys Ile Glu Glu Arg Asn
            580                 585                 590         
Val Asp Leu Lys Asn Asn Ser Leu Glu Ile Asp Gln Thr Glu Asn Val
        595                 600                 605             
Lys Pro Met Leu Arg Gly Arg Phe Gln Arg Pro Lys Pro Asn Leu Ser
    610                 615                 620                 
Arg Ala Gly Lys Lys Ser Val Leu Ser Gln Gly Lys Thr Glu Ser Glu
625                 630                 635                 640 
Ser Lys Asn Ser His Ser Lys Thr Ser Val Glu Lys Asn His Val Glu
                645                 650                 655     
Lys Asp Lys Met Asn Thr Leu Asp Ile Leu Arg Met Glu Thr Thr Glu
            660                 665                 670         
Arg Glu Asn Pro Glu Ala Glu Thr Val Ser Val Leu Gly Glu Lys Asn
        675                 680                 685             
Cys Leu Gln Glu Gly Ser Gln Leu Lys Ala Leu Arg Pro Val Gln Val
    690                 695                 700                 
Arg Gly Arg Leu Gln Lys Pro Lys Pro Asn Ala Gly Lys Ala Ala Glu
705                 710                 715                 720 
Arg Lys Glu Ile Leu Ile Ser Gln Glu Glu Ile Gly Ala Asn Val Glu
                725                 730                 735     
Lys Asn Glu Asn Glu Ser Cys Ala Asp Arg Asp Thr Pro Gln His Met
            740                 745                 750         
Glu Asp Gln Ser Arg Lys Asp Phe Glu Glu Glu Asp Val Ile Leu Gln
        755                 760                 765             
Pro Glu Lys Asn Asp Ser Phe Gln Asn Val Gln Pro Asp Glu Pro Lys
    770                 775                 780                 
Val Leu Asn Glu Cys Leu Ser Val Gln Glu Asn Asn Lys Ala Asn Lys
785                 790                 795                 800 
Leu Asn Gln Val Pro Ile Leu Arg Thr Arg Phe Gln Lys Pro Lys Pro
                805                 810                 815     
Asn Ile Gly Arg Gly Thr Gly Arg Arg Glu Ile Ser Ser Lys Glu Glu
            820                 825                 830         
Val Leu Glu Lys Ile Leu Val Ser Gly Glu Met Ala Ala Ala Leu Arg
        835                 840                 845             
Glu Thr Val Arg Leu Asp Thr Ser Pro Lys Glu Met Val Pro Ala Glu
    850                 855                 860                 
Ile Asn Thr Lys Glu Met Gln Ser Asp Leu Lys Glu Thr Gly Arg Arg
865                 870                 875                 880 
Ala Ile Ser Pro Arg Glu Lys Ile Leu Asp Val Ile Asp Asp Thr Ile
                885                 890                 895     
Glu Met Glu Thr Gly Leu Lys Ala Met Gly Arg Glu Ile Cys Leu Arg
            900                 905                 910         
Glu Lys Thr Pro Glu Val Ile Asp Ala Thr Glu Glu Ile Asp Lys Asp
        915                 920                 925             
Leu Glu Glu Ala Gly Arg Arg Glu Ile Ser Pro Gln Lys Asn Gly Pro
    930                 935                 940                 
Glu Glu Val Lys Pro Leu Gly Glu Val Glu Thr Asp Leu Lys Ala Thr
945                 950                 955                 960 
Gly Asn Glu Ser Ser Pro Arg Glu Lys Thr Pro Glu Val Thr Asp Ala
                965                 970                 975     
Thr Glu Glu Ile Asp Lys Asn Leu Glu Glu Thr Gly Arg Arg Lys Ile
            980                 985                 990         
Ser Pro Arg Glu Asn Gly Pro Glu Glu Val Lys Pro Val Asp Glu Met
        995                 1000                1005            
Gly Thr Asp Leu Asn Ala Thr Gly Arg Glu Ser Ser Pro Arg Glu Lys
    1010                1015                1020                
Thr Pro Glu Val Ile Asp Ala Thr Glu Glu Ile Asp Leu Glu Glu Thr
1025                1030                1035                1040
Glu Arg Glu Val Ser Pro Gln Glu Asn Gly Leu Glu Glu Val Lys Pro
                1045                1050                1055    
Leu Gly Glu Met Glu Thr Asp Leu Lys Ala Thr Gly Arg Asp Ser Phe
            1060                1065                1070        
Pro Arg Gly Lys Thr Pro Glu Val Ile Asp Ala Ile Glu Glu Ile Glu
        1075                1080                1085            
Ile Asp Leu Glu Glu Thr Glu Arg Glu Ile Ser Pro Gln Glu Asn Gly
    1090                1095                1100                
Leu Glu Glu Val Lys Pro Leu Gly Glu Met Gln Thr Asp Leu Lys Ala
1105                1110                1115                1120
Thr Gly Arg Glu Ile Ser Pro Arg Glu Lys Thr Pro Glu Val Ile Asp
                1125                1130                1135    
Ala Thr Glu Glu Ile Asp Lys Asp Leu Glu Glu Thr Gly Arg Arg Glu
            1140                1145                1150        
Ile Ser Pro Glu Glu Asn Gly Pro Glu Glu Val Lys Pro Val Asp Glu
        1155                1160                1165            
Met Glu Thr Asp Leu Lys Thr Thr Gly Arg Glu Gly Ser Ser Arg Glu
    1170                1175                1180                
Lys Thr Arg Glu Val Ile Asp Ala Ala Glu Val Ile Glu Thr Asp Leu
1185                1190                1195                1200
Glu Glu Thr Glu Arg Glu Ile Ser Pro Gln Glu Asn Gly Pro Glu Glu
                1205                1210                1215    
Val Lys Pro Val Gly Lys Met Glu Thr Asp Leu Lys Glu Ile Arg Glu
            1220                1225                1230        
Glu Ile Ser Gln Arg Glu Lys Val Leu Ala Glu Phe Ser Ala Ile Arg
        1235                1240                1245            
Glu Lys Glu Ile Asp Leu Lys Glu Thr Gly Lys Arg Asp Ile Pro Ile
    1250                1255                1260                
Met Glu Lys Val Ser Gly Lys Met Ala Val Val Glu Glu Met Glu Ala
1265                1270                1275                1280
Asp Leu Lys Glu Thr Gly Lys Glu Asn Phe Arg Glu Arg Gly Ser Glu
                1285                1290                1295    
Glu Ile Cys Val Thr Glu Glu Lys Val Ala Glu Leu Lys Gln Thr Gly
            1300                1305                1310        
Lys Thr Asp Ile Ser Pro Arg Glu Asn Glu Leu Glu Glu Thr Ser Thr
        1315                1320                1325            
Ser Arg Gln Thr Asp Thr His Leu Met Gln Ser Gly Ser Asn Asp Phe
    1330                1335                1340                
Ser Ala Met Pro Ser Leu Asp Ile Gln Val Cys Ile Phe Leu Ser Phe
1345                1350                1355                1360
Lys Ser Phe Leu Asn Ala Phe Ser Glu Glu Ile Asn Asn Ser Met Ile
                1365                1370                1375    
Ile Leu Ser Leu Ser Pro Thr Thr Leu Lys Asn Leu
            1380                1385            


<210> 1140
<211> 797
<212> PRT
<213> Homo sapiens

<400> 1140
Met Ala Ala Ala Pro Val Ala Ala Gly Ser Gly Ala Gly Arg Gly Arg
 1               5                  10                  15      
Arg Ser Ala Ala Thr Val Ala Ala Trp Gly Gly Trp Gly Gly Arg Pro
            20                  25                  30          
Arg Pro Gly Asn Ile Leu Leu Gln Leu Arg Gln Gly Gln Leu Thr Gly
        35                  40                  45              
Arg Gly Leu Val Arg Ala Val Gln Phe Thr Glu Thr Phe Leu Thr Glu
    50                  55                  60                  
Arg Asp Lys Gln Ser Lys Trp Ser Gly Ile Pro Gln Leu Leu Leu Lys
65                  70                  75                  80  
Leu His Thr Thr Ser His Leu His Ser Asp Phe Val Glu Cys Gln Asn
                85                  90                  95      
Ile Leu Lys Glu Ile Ser Pro Leu Leu Ser Met Glu Ala Met Ala Phe
            100                 105                 110         
Val Thr Glu Glu Arg Lys Leu Thr Gln Glu Thr Thr Tyr Pro Asn Thr
        115                 120                 125             
Tyr Ile Phe Asp Leu Phe Gly Gly Val Asp Leu Leu Val Glu Ile Leu
    130                 135                 140                 
Met Arg Pro Thr Ile Ser Ile Arg Gly Gln Lys Leu Lys Ile Ser Asp
145                 150                 155                 160 
Glu Met Ser Lys Asp Cys Leu Ser Ile Leu Tyr Asn Thr Cys Val Cys
                165                 170                 175     
Thr Glu Gly Val Thr Lys Arg Leu Ala Glu Lys Asn Asp Phe Val Ile
            180                 185                 190         
Phe Leu Phe Thr Leu Met Thr Ser Lys Lys Thr Phe Leu Gln Thr Ala
        195                 200                 205             
Thr Leu Ile Glu Asp Ile Leu Gly Val Lys Lys Glu Met Ile Arg Leu
    210                 215                 220                 
Asp Glu Val Pro Asn Leu Ser Ser Leu Val Ser Asn Phe Asp Gln Gln
225                 230                 235                 240 
Gln Leu Ala Asn Phe Cys Arg Ile Leu Ala Val Thr Ile Ser Glu Met
                245                 250                 255     
Asp Thr Gly Asn Asp Asp Lys His Thr Leu Leu Ala Lys Asn Ala Gln
            260                 265                 270         
Gln Lys Lys Ser Leu Ser Leu Gly Pro Ser Ala Ala Glu Ile Asn Gln
        275                 280                 285             
Ala Ala Leu Leu Ser Ile Pro Gly Phe Val Glu Arg Leu Cys Lys Leu
    290                 295                 300                 
Ala Thr Arg Lys Val Ser Glu Ser Thr Gly Thr Ala Ser Phe Leu Gln
305                 310                 315                 320 
Glu Leu Glu Glu Trp Tyr Thr Trp Leu Asp Asn Ala Leu Val Leu Asp
                325                 330                 335     
Ala Leu Met Arg Val Ala Asn Glu Glu Ser Glu His Asn Gln Ala Ser
            340                 345                 350         
Ile Val Phe Pro Pro Pro Gly Ala Ser Glu Glu Asn Gly Leu Pro His
        355                 360                 365             
Thr Ser Ala Arg Thr Gln Leu Pro Gln Ser Met Lys Ile Met His Glu
    370                 375                 380                 
Ile Met Tyr Lys Leu Glu Val Leu Tyr Val Leu Cys Val Leu Leu Met
385                 390                 395                 400 
Gly Arg Gln Arg Asn Gln Val His Arg Met Ile Ala Glu Phe Lys Leu
                405                 410                 415     
Ile Pro Gly Leu Asn Asn Leu Phe Asp Lys Leu Ile Trp Arg Lys His
            420                 425                 430         
Ser Ala Ser Ala Leu Val Leu His Gly His Asn Gln Asn Cys Asp Cys
        435                 440                 445             
Ser Pro Asp Ile Thr Leu Lys Ile Gln Phe Leu Arg Leu Leu Gln Ser
    450                 455                 460                 
Phe Ser Asp His His Glu Asn Lys Tyr Leu Leu Leu Asn Asn Gln Glu
465                 470                 475                 480 
Leu Asn Glu Leu Ser Ala Ile Ser Leu Lys Ala Asn Ile Pro Glu Val
                485                 490                 495     
Glu Ala Val Leu Asn Thr Asp Arg Ser Leu Val Cys Asp Gly Lys Arg
            500                 505                 510         
Gly Leu Leu Thr Arg Leu Leu Gln Val Met Lys Lys Glu Pro Ala Glu
        515                 520                 525             
Ser Ser Phe Arg Phe Trp Gln Ala Arg Ala Val Glu Ser Phe Leu Arg
    530                 535                 540                 
Gly Thr Thr Ser Tyr Ala Asp Gln Met Phe Leu Leu Lys Arg Gly Leu
545                 550                 555                 560 
Leu Glu His Ile Leu Tyr Cys Ile Val Asp Ser Glu Cys Lys Ser Arg
                565                 570                 575     
Asp Val Leu Gln Ser Tyr Phe Asp Leu Leu Gly Glu Leu Met Lys Phe
            580                 585                 590         
Asn Val Asp Ala Phe Lys Arg Phe Asn Lys Tyr Ile Asn Thr Asp Ala
        595                 600                 605             
Lys Phe Gln Val Phe Leu Lys Gln Ile Asn Ser Ser Leu Val Asp Ser
    610                 615                 620                 
Asn Met Leu Val Arg Cys Val Thr Leu Ser Leu Asp Arg Phe Glu Asn
625                 630                 635                 640 
Gln Val Asp Met Lys Val Ala Glu Val Leu Ser Glu Cys Arg Leu Leu
                645                 650                 655     
Ala Tyr Ile Ser Gln Val Pro Thr Gln Met Ser Phe Leu Phe Arg Leu
            660                 665                 670         
Ile Asn Ile Ile His Val Gln Thr Leu Thr Gln Glu Asn Val Ser Cys
        675                 680                 685             
Leu Asn Thr Ser Leu Val Ile Leu Met Leu Ala Arg Arg Lys Glu Arg
    690                 695                 700                 
Leu Pro Leu Tyr Leu Arg Leu Leu Gln Arg Met Glu His Ser Lys Lys
705                 710                 715                 720 
Tyr Pro Gly Phe Leu Leu Asn Asn Phe His Asn Leu Leu Arg Phe Trp
                725                 730                 735     
Gln Gln His Tyr Leu His Lys Asp Lys Asp Ser Thr Cys Leu Glu Asn
            740                 745                 750         
Ser Ser Cys Ile Ser Phe Ser Tyr Trp Lys Glu Thr Val Ser Ile Leu
        755                 760                 765             
Leu Asn Pro Asp Arg Gln Ser Pro Ser Ala Leu Val Ser Tyr Ile Glu
    770                 775                 780                 
Glu Pro Tyr Met Asp Ile Asp Arg Asp Phe Thr Glu Glu
785                 790                 795         


<210> 1141
<211> 492
<212> PRT
<213> Homo sapiens

<400> 1141
Met Gly Gly Asn Ile Ser Val Ala Phe Ala Ala Pro Arg Gln Arg Gly
 1               5                  10                  15      
Lys Gly Glu Ile Thr Pro Ala Ala Ile Gln Lys Met Leu Asp Asp Asn
            20                  25                  30          
Asn His Leu Ile Gln Cys Ile Met Asp Ser Gln Asn Lys Gly Lys Thr
        35                  40                  45              
Ser Glu Cys Ser Gln Tyr Gln Gln Met Leu His Thr Asn Leu Val Tyr
    50                  55                  60                  
Leu Ala Thr Ile Ala Asp Ser Asn Gln Asn Met Gln Ser Leu Leu Pro
65                  70                  75                  80  
Ala Pro Pro Thr Gln Asn Met Pro Met Gly Pro Gly Gly Met Asn Gln
                85                  90                  95      
Ser Gly Pro Pro Pro Pro Pro Arg Ser His Asn Met Pro Ser Asp Gly
            100                 105                 110         
Met Val Gly Gly Gly Pro Pro Ala Pro His Met Gln Asn Gln Met Asn
        115                 120                 125             
Gly Gln Met Pro Gly Pro Asn His Met Pro Met Gln Gly Pro Gly Pro
    130                 135                 140                 
Asn Gln Leu Asn Met Thr Asn Ser Ser Met Asn Met Pro Ser Ser Ser
145                 150                 155                 160 
His Gly Ser Met Gly Gly Tyr Asn His Ser Val Pro Ser Ser Gln Ser
                165                 170                 175     
Met Pro Val Gln Asn Gln Met Thr Met Ser Gln Gly Gln Pro Met Gly
            180                 185                 190         
Asn Tyr Gly Pro Arg Pro Asn Met Ser Met Gln Pro Asn Gln Gly Pro
        195                 200                 205             
Met Met Arg Gln Gln Pro Pro Ser Gln Gln Tyr Asn Met Pro Gln Gly
    210                 215                 220                 
Gly Gly Gln His Tyr Gln Gly Gln Gln Pro Pro Met Gly Met Met Gly
225                 230                 235                 240 
Gln Val Asn Gln Gly Asn His Met Met Gly Gln Arg Gln Ile Pro Pro
                245                 250                 255     
Tyr Arg Pro Pro Gln Gln Gly Pro Pro Gln Gln Tyr Ser Gly Gln Glu
            260                 265                 270         
Asp Tyr Tyr Gly Asp Gln Tyr Ser His Gly Gly Gln Gly Pro Pro Glu
        275                 280                 285             
Gly Met Asn Gln Gln Tyr Tyr Pro Asp Gly His Asn Asp Tyr Gly Tyr
    290                 295                 300                 
Gln Gln Pro Ser Tyr Pro Glu Gln Gly Tyr Asp Arg Pro Tyr Glu Asp
305                 310                 315                 320 
Ser Ser Gln His Tyr Tyr Glu Gly Gly Asn Ser Gln Tyr Gly Gln Gln
                325                 330                 335     
Gln Asp Ala Tyr Gln Gly Pro Pro Pro Gln Gln Gly Tyr Pro Pro Gln
            340                 345                 350         
Gln Gln Gln Tyr Pro Gly Gln Gln Gly Tyr Pro Gly Gln Gln Gln Gly
        355                 360                 365             
Tyr Gly Pro Ser Gln Gly Gly Pro Gly Pro Gln Tyr Pro Asn Tyr Pro
    370                 375                 380                 
Gln Gly Gln Gly Gln Gln Tyr Gly Gly Tyr Arg Pro Thr Gln Pro Gly
385                 390                 395                 400 
Pro Pro Gln Pro Pro Gln Gln Arg Pro Tyr Gly Tyr Asp Gln Ile Met
                405                 410                 415     
Pro Lys Lys Pro Ala Glu Glu Glu Asn Gly Leu Lys Glu Val Pro Glu
            420                 425                 430         
Ala Ser Gly Pro Gln Asn Asp Gly Lys Gln Leu Cys Pro Pro Gly Asn
        435                 440                 445             
Pro Ser Thr Leu Glu Lys Ile Asn Lys Thr Ser Gly Pro Lys Arg Gly
    450                 455                 460                 
Lys His Ala Trp Thr His Arg Leu Arg Glu Arg Lys Gln Leu Val Val
465                 470                 475                 480 
Tyr Glu Glu Ile Ser Asp Pro Glu Glu Asp Asp Glu
                485                 490         


<210> 1142
<211> 105
<212> PRT
<213> Homo sapiens

<400> 1142
Met Gly Asp Val Glu Lys Gly Lys Lys Ile Phe Ile Met Lys Cys Ser
 1               5                  10                  15      
Gln Cys His Thr Val Glu Lys Gly Gly Lys His Lys Thr Gly Pro Asn
            20                  25                  30          
Leu His Gly Leu Phe Gly Arg Lys Thr Gly Gln Ala Pro Gly Tyr Ser
        35                  40                  45              
Tyr Thr Ala Ala Asn Lys Asn Lys Gly Ile Ile Trp Gly Glu Asp Thr
    50                  55                  60                  
Leu Met Glu Tyr Leu Glu Asn Pro Lys Lys Tyr Ile Pro Gly Thr Lys
65                  70                  75                  80  
Met Ile Phe Val Gly Ile Lys Lys Lys Glu Glu Arg Ala Asp Leu Ile
                85                  90                  95      
Ala Tyr Leu Lys Lys Ala Thr Asn Glu
            100                 105 


<210> 1143
<211> 923
<212> PRT
<213> Homo sapiens

<400> 1143
Met Gly Ser Gly Ala Gly Glu Leu Gly Arg Ala Glu Arg Leu Pro Val
 1               5                  10                  15      
Leu Phe Leu Phe Leu Leu Ser Leu Phe Cys Pro Ala Leu Cys Glu Gln
            20                  25                  30          
Ile Arg Tyr Arg Ile Pro Glu Glu Met Pro Lys Gly Ser Val Val Gly
        35                  40                  45              
Asn Leu Ala Thr Asp Leu Gly Phe Ser Val Gln Glu Leu Pro Thr Arg
    50                  55                  60                  
Lys Leu Arg Val Ser Ser Glu Lys Pro Tyr Phe Thr Val Ser Ala Glu
65                  70                  75                  80  
Ser Gly Glu Leu Leu Val Ser Ser Arg Leu Asp Arg Glu Glu Ile Cys
                85                  90                  95      
Gly Lys Lys Pro Ala Cys Ala Leu Glu Phe Glu Ala Val Ala Glu Asn
            100                 105                 110         
Pro Leu Asn Phe Tyr His Val Asn Val Glu Ile Glu Asp Ile Asn Asp
        115                 120                 125             
His Thr Pro Lys Phe Thr Gln Asn Ser Phe Glu Leu Gln Ile Ser Glu
    130                 135                 140                 
Ser Ala Gln Pro Gly Thr Arg Phe Ile Leu Glu Val Ala Glu Asp Ala
145                 150                 155                 160 
Asp Ile Gly Leu Asn Ser Leu Gln Lys Tyr Lys Leu Ser Leu Asn Pro
                165                 170                 175     
Ser Phe Ser Leu Ile Ile Lys Glu Lys Gln Asp Gly Ser Lys Tyr Pro
            180                 185                 190         
Glu Leu Ala Leu Glu Lys Thr Leu Asp Arg Glu Gln Gln Ser Tyr His
        195                 200                 205             
Arg Leu Val Leu Thr Ala Leu Asp Gly Gly His Pro Pro Leu Ser Gly
    210                 215                 220                 
Thr Thr Glu Leu Arg Ile Gln Val Thr Asp Ala Asn Asp Asn Pro Pro
225                 230                 235                 240 
Val Phe Asn Arg Asp Val Tyr Arg Val Ser Leu Arg Glu Asn Val Pro
                245                 250                 255     
Pro Gly Thr Thr Val Leu Gln Val Ser Ala Thr Asp Gln Asp Glu Gly
            260                 265                 270         
Ile Asn Ser Glu Ile Thr Tyr Ser Phe Tyr Arg Thr Gly Gln Ile Phe
        275                 280                 285             
Ser Leu Asn Ser Lys Ser Gly Glu Ile Thr Thr Gln Lys Lys Leu Asp
    290                 295                 300                 
Phe Glu Glu Thr Lys Glu Tyr Ser Met Val Val Glu Gly Arg Asp Gly
305                 310                 315                 320 
Gly Gly Leu Val Ala Gln Cys Thr Val Glu Ile Asn Ile Gln Asp Glu
                325                 330                 335     
Asn Asp Asn Ser Pro Glu Val Thr Phe His Ser Leu Leu Glu Met Ile
            340                 345                 350         
Leu Glu Asn Ala Val Pro Gly Thr Leu Ile Ala Leu Ile Lys Ile His
        355                 360                 365             
Asp Gln Asp Ser Gly Glu Asn Gly Glu Val Asn Cys Gln Leu Gln Gly
    370                 375                 380                 
Glu Val Pro Phe Lys Ile Ile Ser Ser Ser Lys Asn Ser Tyr Lys Leu
385                 390                 395                 400 
Val Thr Asp Gly Thr Leu Asp Arg Glu Gln Thr Pro Glu Tyr Asn Val
                405                 410                 415     
Thr Ile Thr Ala Thr Asp Arg Gly Lys Pro Pro Leu Ser Ser Ser Ile
            420                 425                 430         
Ser Val Ile Leu His Ile Arg Asp Val Asn Asp Asn Ala Pro Val Phe
        435                 440                 445             
His Gln Ala Ser Tyr Leu Val Ser Val Pro Glu Asn Asn Pro Pro Gly
    450                 455                 460                 
Ala Ser Ile Ala Gln Val Cys Ala Ser Asp Leu Asp Leu Gly Leu Asn
465                 470                 475                 480 
Gly Gln Val Ser Tyr Ser Ile Met Ala Ser Asp Leu Glu Pro Leu Ala
                485                 490                 495     
Leu Ala Ser Tyr Val Ser Met Ser Ala Gln Ser Gly Val Val Phe Ala
            500                 505                 510         
Gln Arg Ala Phe Asp Tyr Glu Gln Leu Arg Thr Phe Glu Leu Thr Leu
        515                 520                 525             
Gln Ala Arg Asp Gln Gly Ser Pro Ala Leu Ser Ala Asn Val Ser Leu
    530                 535                 540                 
Arg Val Leu Val Gly Asp Arg Asn Asp Asn Ala Pro Arg Val Leu Tyr
545                 550                 555                 560 
Pro Ala Leu Gly Pro Asp Gly Ser Ala Leu Phe Asp Met Val Pro Arg
                565                 570                 575     
Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val Asp Ala
            580                 585                 590         
Asp Ser Gly His Asn Ala Trp Leu Ser Tyr His Val Leu Gln Ala Ser
        595                 600                 605             
Glu Pro Gly Leu Phe Ser Leu Gly Leu Arg Thr Gly Glu Val Arg Thr
    610                 615                 620                 
Ala Arg Ala Leu Gly Asp Arg Asp Ala Ala Arg Gln Arg Leu Leu Val
625                 630                 635                 640 
Ala Val Arg Asp Gly Gly Gln Pro Pro Leu Ser Ala Thr Ala Thr Leu
                645                 650                 655     
His Leu Val Phe Ala Asp Ser Leu Gln Glu Val Leu Pro Asp Ile Thr
            660                 665                 670         
Asp Arg Pro Val Pro Ser Asp Pro Gln Ala Glu Leu Gln Phe Tyr Leu
        675                 680                 685             
Val Val Ala Leu Ala Leu Ile Ser Val Leu Phe Leu Leu Ala Val Ile
    690                 695                 700                 
Leu Ala Val Ala Leu Arg Leu Arg Arg Ser Ser Ser Pro Ala Ala Trp
705                 710                 715                 720 
Ser Cys Phe Gln Pro Gly Leu Cys Val Lys Ser Gly Pro Val Val Pro
                725                 730                 735     
Pro Asn Tyr Ser Gln Gly Thr Leu Pro Tyr Ser Tyr Asn Leu Cys Val
            740                 745                 750         
Ala His Thr Gly Lys Thr Glu Phe Asn Phe Leu Lys Cys Ser Glu Gln
        755                 760                 765             
Leu Ser Ser Gly Gln Asp Ile Leu Cys Gly Asp Ser Ser Gly Ala Leu
    770                 775                 780                 
Phe Pro Leu Cys Asn Ser Ser Glu Ser Thr Ser His Pro Glu Leu Gln
785                 790                 795                 800 
Ala Pro Pro Asn Thr Asp Trp Arg Phe Ser Gln Ala Gln Arg Pro Gly
                805                 810                 815     
Thr Ser Gly Ser Gln Asn Gly Asp Asp Thr Gly Thr Trp Pro Asn Asn
            820                 825                 830         
Gln Phe Asp Thr Glu Met Leu Gln Ala Met Ile Leu Ala Ser Ala Ser
        835                 840                 845             
Glu Ala Ala Asp Gly Ser Ser Thr Leu Gly Gly Gly Ala Gly Thr Met
    850                 855                 860                 
Gly Leu Ser Ala Arg Tyr Gly Pro Gln Phe Thr Leu Gln His Val Pro
865                 870                 875                 880 
Asp Tyr Arg Gln Asn Val Tyr Ile Pro Gly Ser Asn Ala Thr Leu Thr
                885                 890                 895     
Asn Ala Ala Gly Lys Arg Asp Gly Lys Ala Pro Ala Gly Gly Asn Gly
            900                 905                 910         
Asn Lys Lys Lys Ser Gly Lys Lys Glu Lys Lys
        915                 920             


<210> 1144
<211> 216
<212> PRT
<213> Homo sapiens

<400> 1144
Ala Ala Gln Cys Val Arg Leu Ala Arg Arg Ser Leu Pro Ala Leu Ala
 1               5                  10                  15      
Leu Ser Leu Arg Pro Ser Pro Arg Leu Leu Cys Thr Ala Thr Lys Gln
            20                  25                  30          
Lys Asn Ser Gly Gln Asn Leu Glu Glu Asp Met Gly Gln Ser Glu Gln
        35                  40                  45              
Lys Ala Asp Pro Pro Ala Thr Glu Lys Thr Leu Leu Glu Glu Lys Val
    50                  55                  60                  
Lys Leu Glu Glu Gln Leu Lys Glu Thr Val Glu Lys Tyr Lys Arg Ala
65                  70                  75                  80  
Leu Ala Asp Thr Glu Asn Leu Arg Gln Arg Ser Gln Lys Leu Val Glu
                85                  90                  95      
Glu Ala Lys Leu Tyr Gly Ile Gln Ala Phe Cys Lys Asp Leu Leu Glu
            100                 105                 110         
Val Ala Asp Val Leu Glu Lys Ala Thr Gln Cys Val Pro Lys Glu Glu
        115                 120                 125             
Ile Lys Asp Asp Asn Pro His Leu Lys Asn Leu Tyr Glu Gly Leu Val
    130                 135                 140                 
Met Thr Glu Val Gln Ile Gln Lys Val Phe Thr Lys His Gly Leu Leu
145                 150                 155                 160 
Lys Leu Asn Pro Val Gly Ala Lys Phe Asp Pro Tyr Glu His Glu Ala
                165                 170                 175     
Leu Phe His Thr Pro Val Glu Gly Lys Glu Pro Gly Thr Val Ala Leu
            180                 185                 190         
Val Ser Lys Val Gly Tyr Lys Leu His Gly Arg Thr Leu Arg Pro Ala
        195                 200                 205             
Leu Val Gly Val Val Lys Glu Ala
    210                 215     


<210> 1145
<211> 580
<212> PRT
<213> Homo sapiens

<400> 1145
Met Ala Phe His Val Glu Gly Leu Ile Ala Ile Ile Val Phe Tyr Leu
 1               5                  10                  15      
Leu Ile Leu Leu Val Gly Ile Trp Ala Ala Trp Arg Thr Lys Asn Ser
            20                  25                  30          
Gly Ser Ala Glu Glu Arg Ser Glu Ala Ile Ile Val Gly Gly Arg Asp
        35                  40                  45              
Ile Gly Leu Leu Val Gly Gly Phe Thr Met Thr Ala Thr Trp Val Gly
    50                  55                  60                  
Gly Gly Tyr Ile Asn Gly Thr Ala Glu Ala Val Tyr Val Pro Gly Tyr
65                  70                  75                  80  
Gly Leu Ala Trp Ala Gln Ala Pro Ile Gly Tyr Ser Leu Ser Leu Ile
                85                  90                  95      
Leu Gly Gly Leu Phe Phe Ala Lys Pro Met Arg Ser Lys Gly Tyr Val
            100                 105                 110         
Thr Met Leu Asp Pro Phe Gln Gln Ile Tyr Gly Lys Arg Met Gly Gly
        115                 120                 125             
Leu Leu Phe Ile Pro Ala Leu Met Gly Glu Met Phe Trp Ala Ala Ala
    130                 135                 140                 
Ile Phe Ser Ala Leu Gly Ala Thr Ile Ser Val Ile Ile Asp Val Asp
145                 150                 155                 160 
Met His Ile Ser Val Ile Ile Ser Ala Leu Ile Ala Thr Leu Tyr Thr
                165                 170                 175     
Leu Val Gly Gly Leu Tyr Ser Val Ala Tyr Thr Asp Val Val Gln Leu
            180                 185                 190         
Phe Cys Ile Phe Val Gly Leu Trp Ile Ser Val Pro Phe Ala Leu Ser
        195                 200                 205             
His Pro Ala Val Ala Asp Ile Gly Phe Thr Ala Val His Ala Lys Tyr
    210                 215                 220                 
Gln Lys Pro Trp Leu Gly Thr Val Asp Ser Ser Glu Val Tyr Ser Trp
225                 230                 235                 240 
Leu Asp Ser Phe Leu Leu Leu Met Leu Gly Gly Ile Pro Trp Gln Ala
                245                 250                 255     
Tyr Phe Gln Arg Val Leu Ser Ser Ser Ser Ala Thr Tyr Ala Gln Val
            260                 265                 270         
Leu Ser Phe Leu Ala Ala Phe Gly Cys Leu Val Met Ala Ile Pro Ala
        275                 280                 285             
Ile Leu Ile Gly Ala Ile Gly Ala Ser Thr Asp Trp Asn Gln Thr Ala
    290                 295                 300                 
Tyr Gly Leu Pro Asp Pro Lys Thr Thr Glu Glu Ala Asp Met Ile Leu
305                 310                 315                 320 
Pro Ile Val Leu Gln Tyr Leu Cys Pro Val Tyr Ile Ser Phe Phe Gly
                325                 330                 335     
Leu Gly Ala Val Ser Ala Ala Val Met Ser Ser Ala Asp Ser Ser Ile
            340                 345                 350         
Leu Ser Ala Ser Ser Met Phe Ala Arg Asn Ile Tyr Gln Leu Ser Phe
        355                 360                 365             
Arg Gln Asn Ala Ser Asp Lys Glu Ile Val Trp Val Met Arg Ile Thr
    370                 375                 380                 
Val Phe Val Phe Gly Ala Ser Ala Thr Ala Met Ala Leu Leu Thr Lys
385                 390                 395                 400 
Thr Val Tyr Gly Leu Trp Tyr Leu Ser Ser Asp Leu Val Tyr Ile Val
                405                 410                 415     
Ile Phe Pro Gln Leu Leu Cys Val Leu Phe Val Lys Gly Thr Asn Thr
            420                 425                 430         
Tyr Gly Ala Val Ala Gly Tyr Val Ser Gly Leu Phe Leu Arg Ile Thr
        435                 440                 445             
Gly Gly Glu Pro Tyr Leu Tyr Leu Gln Pro Leu Ile Phe Tyr Pro Gly
    450                 455                 460                 
Tyr Tyr Pro Asp Asp Asn Gly Ile Tyr Asn Gln Lys Phe Pro Phe Lys
465                 470                 475                 480 
Thr Leu Ala Met Val Thr Ser Phe Leu Thr Asn Ile Cys Ile Ser Tyr
                485                 490                 495     
Leu Ala Lys Tyr Leu Phe Glu Ser Gly Thr Leu Pro Pro Lys Leu Asp
            500                 505                 510         
Val Phe Asp Ala Val Val Ala Arg His Ser Glu Glu Asn Met Asp Lys
        515                 520                 525             
Thr Ile Leu Val Lys Asn Glu Asn Ile Lys Leu Asp Glu Leu Ala Leu
    530                 535                 540                 
Val Lys Pro Arg Gln Ser Met Thr Leu Ser Ser Thr Phe Thr Asn Lys
545                 550                 555                 560 
Glu Ala Phe Leu Asp Val Asp Ser Ser Pro Glu Gly Ser Gly Thr Glu
                565                 570                 575     
Asp Asn Leu Gln
            580 


<210> 1146
<211> 526
<212> PRT
<213> Homo sapiens

<400> 1146
Met Pro Ala Val Ser Gly Pro Gly Pro Leu Phe Cys Leu Leu Leu Leu
 1               5                  10                  15      
Leu Leu Asp Pro His Ser Pro Glu Thr Gly Cys Pro Pro Leu Arg Arg
            20                  25                  30          
Phe Glu Tyr Lys Leu Ser Phe Lys Gly Pro Arg Leu Ala Leu Pro Gly
        35                  40                  45              
Ala Gly Ile Pro Phe Trp Ser His His Gly Asp Ala Ile Leu Gly Leu
    50                  55                  60                  
Glu Glu Val Arg Leu Thr Pro Ser Met Arg Asn Arg Ser Gly Ala Val
65                  70                  75                  80  
Trp Ser Arg Ala Ser Val Pro Phe Ser Ala Trp Glu Val Glu Val Gln
                85                  90                  95      
Met Arg Val Thr Gly Leu Gly Arg Arg Gly Ala His Gly Met Ala Val
            100                 105                 110         
Trp Tyr Thr Arg Gly Arg Gly His Val Gly Ser Val Leu Gly Gly Leu
        115                 120                 125             
Ala Ser Trp Asp Gly Ile Gly Ile Phe Phe Asp Ser Pro Ala Glu Asp
    130                 135                 140                 
Thr Gln Asp Ser Pro Ala Ile Arg Val Leu Ala Ser Asp Gly His Ile
145                 150                 155                 160 
Pro Ser Glu Gln Pro Gly Asp Gly Ala Ser Gln Gly Leu Gly Ser Cys
                165                 170                 175     
His Trp Asp Phe Arg Asn Arg Pro His Pro Phe Arg Ala Arg Ile Thr
            180                 185                 190         
Tyr Trp Gly Gln Arg Leu Arg Met Ser Leu Asn Ser Gly Leu Thr Pro
        195                 200                 205             
Ser Asp Pro Gly Glu Phe Cys Val Asp Val Gly Pro Leu Leu Leu Val
    210                 215                 220                 
Pro Gly Gly Phe Phe Gly Val Ser Ala Ala Thr Gly Thr Leu Ala Asp
225                 230                 235                 240 
Asp His Asp Val Leu Ser Phe Leu Thr Phe Ser Leu Ser Glu Pro Ser
                245                 250                 255     
Pro Glu Val Pro Pro Gln Pro Phe Leu Glu Met Gln Gln Leu Arg Leu
            260                 265                 270         
Ala Arg Gln Leu Glu Gly Leu Trp Ala Arg Leu Gly Leu Gly Thr Arg
        275                 280                 285             
Glu Asp Val Thr Pro Lys Ser Asp Ser Glu Ala Gln Gly Glu Gly Glu
    290                 295                 300                 
Arg Leu Phe Asp Leu Glu Glu Thr Leu Gly Arg His Arg Arg Ile Leu
305                 310                 315                 320 
Gln Ala Leu Arg Gly Leu Ser Lys Gln Leu Ala Gln Ala Glu Arg Gln
                325                 330                 335     
Trp Lys Lys Gln Leu Gly Pro Pro Gly Gln Ala Arg Pro Asp Gly Gly
            340                 345                 350         
Trp Ala Leu Asp Ala Ser Cys Gln Ile Pro Ser Thr Pro Gly Arg Gly
        355                 360                 365             
Gly His Leu Ser Met Ser Leu Asn Lys Asp Ser Ala Lys Val Gly Ala
    370                 375                 380                 
Leu Leu His Gly Gln Trp Thr Leu Leu Gln Ala Leu Gln Glu Met Arg
385                 390                 395                 400 
Asp Ala Ala Val Arg Met Ala Ala Glu Ala Gln Val Ser Tyr Leu Pro
                405                 410                 415     
Val Gly Ile Glu His His Phe Leu Glu Leu Asp His Ile Leu Gly Leu
            420                 425                 430         
Leu Gln Glu Glu Leu Arg Gly Pro Ala Lys Ala Ala Ala Lys Ala Pro
        435                 440                 445             
Arg Pro Pro Gly Gln Pro Pro Arg Ala Ser Ser Cys Leu Gln Pro Gly
    450                 455                 460                 
Ile Phe Leu Phe Tyr Leu Leu Ile Gln Thr Val Gly Phe Phe Gly Tyr
465                 470                 475                 480 
Val His Phe Arg Gln Glu Leu Asn Lys Ser Leu Gln Glu Cys Leu Ser
                485                 490                 495     
Thr Gly Ser Leu Pro Leu Gly Pro Ala Pro His Thr Pro Arg Ala Leu
            500                 505                 510         
Gly Ile Leu Arg Arg Gln Pro Leu Pro Ala Ser Met Pro Ala
        515                 520                 525     


<210> 1147
<211> 198
<212> PRT
<213> Homo sapiens

<400> 1147
Met Leu Pro Ala Ala Ala Arg Pro Leu Trp Gly Pro Cys Leu Gly Leu
 1               5                  10                  15      
Arg Ala Ala Ala Phe Arg Leu Ala Arg Arg Gln Val Pro Cys Val Cys
            20                  25                  30          
Ala Val Arg His Met Arg Ser Ser Gly His Gln Arg Cys Glu Ala Leu
        35                  40                  45              
Ala Gly Ala Pro Leu Asp Asn Ala Pro Lys Glu Tyr Pro Pro Lys Ile
    50                  55                  60                  
Gln Gln Leu Val Gln Asp Ile Ala Ser Leu Thr Leu Leu Glu Ile Ser
65                  70                  75                  80  
Asp Leu Asn Glu Leu Leu Lys Lys Thr Leu Lys Ile Gln Asp Val Gly
                85                  90                  95      
Leu Val Pro Met Gly Gly Val Met Ser Gly Ala Val Pro Ala Ala Ala
            100                 105                 110         
Ala Gln Glu Ala Val Glu Glu Asp Ile Pro Ile Ala Lys Glu Arg Thr
        115                 120                 125             
His Phe Thr Val Arg Leu Thr Glu Ala Lys Pro Val Asp Lys Val Lys
    130                 135                 140                 
Leu Ile Lys Glu Ile Lys Asn Tyr Ile Gln Gly Ile Asn Leu Val Gln
145                 150                 155                 160 
Ala Lys Lys Leu Val Glu Ser Leu Pro Gln Glu Ile Lys Ala Asn Val
                165                 170                 175     
Ala Lys Ala Glu Ala Glu Lys Ile Lys Ala Ala Leu Glu Ala Val Gly
            180                 185                 190         
Gly Thr Val Val Leu Glu
        195             


<210> 1148
<211> 198
<212> PRT
<213> Homo sapiens

<400> 1148
Met Leu Pro Ala Ala Ala Arg Pro Leu Trp Gly Pro Cys Leu Gly Leu
 1               5                  10                  15      
Arg Ala Ala Ala Phe Arg Leu Ala Arg Arg Gln Val Pro Cys Val Cys
            20                  25                  30          
Ala Val Arg His Met Arg Ser Ser Gly His Gln Arg Cys Glu Ala Leu
        35                  40                  45              
Ala Gly Ala Pro Leu Asp Asn Ala Pro Lys Glu Tyr Pro Pro Lys Ile
    50                  55                  60                  
Gln Gln Leu Val Gln Asp Ile Ala Ser Leu Thr Leu Leu Glu Ile Ser
65                  70                  75                  80  
Asp Leu Asn Glu Leu Leu Lys Lys Thr Leu Lys Ile Gln Asp Val Gly
                85                  90                  95      
Leu Val Pro Met Gly Gly Val Met Ser Gly Ala Val Pro Ala Ala Ala
            100                 105                 110         
Ala Gln Glu Ala Val Glu Glu Asp Ile Pro Ile Ala Lys Glu Arg Thr
        115                 120                 125             
His Phe Thr Val Arg Leu Thr Glu Ala Lys Pro Val Asp Lys Val Lys
    130                 135                 140                 
Leu Ile Lys Glu Ile Lys Asn Tyr Ile Gln Gly Ile Asn Leu Val Gln
145                 150                 155                 160 
Ala Lys Lys Leu Val Glu Ser Leu Pro Gln Glu Ile Lys Ala Asn Val
                165                 170                 175     
Ala Lys Ala Glu Ala Glu Lys Ile Lys Ala Ala Leu Glu Ala Val Gly
            180                 185                 190         
Gly Thr Val Val Leu Glu
        195             


<210> 1149
<211> 765
<212> PRT
<213> Homo sapiens

<400> 1149
Met Ser Gly Asp His Leu His Asn Asp Ser Gln Ile Glu Ala Asp Phe
 1               5                  10                  15      
Arg Leu Asn Asp Ser His Lys His Lys Asp Lys His Lys Asp Arg Glu
            20                  25                  30          
His Arg His Lys Glu His Lys Lys Glu Lys Asp Arg Glu Lys Ser Lys
        35                  40                  45              
His Ser Asn Ser Glu His Lys Asp Ser Glu Lys Lys His Lys Glu Lys
    50                  55                  60                  
Glu Lys Thr Lys His Lys Asp Gly Ser Ser Glu Lys His Lys Asp Lys
65                  70                  75                  80  
His Lys Asp Arg Asp Lys Glu Lys Arg Lys Glu Glu Lys Val Arg Ala
                85                  90                  95      
Ser Gly Asp Ala Lys Ile Lys Lys Glu Lys Glu Asn Gly Phe Ser Ser
            100                 105                 110         
Pro Pro Gln Ile Lys Asp Glu Pro Glu Asp Asp Gly Tyr Phe Val Pro
        115                 120                 125             
Pro Lys Glu Asp Ile Lys Pro Leu Lys Arg Pro Arg Asp Glu Asp Asp
    130                 135                 140                 
Ala Asp Tyr Lys Pro Lys Lys Ile Lys Thr Glu Asp Thr Lys Lys Glu
145                 150                 155                 160 
Lys Lys Arg Lys Leu Glu Glu Glu Glu Asp Gly Lys Leu Lys Lys Pro
                165                 170                 175     
Lys Asn Lys Asp Lys Asp Lys Lys Val Pro Glu Pro Asp Asn Lys Lys
            180                 185                 190         
Lys Lys Pro Lys Lys Glu Glu Glu Gln Lys Trp Lys Trp Trp Glu Glu
        195                 200                 205             
Glu Arg Tyr Pro Glu Gly Ile Lys Trp Lys Phe Leu Glu His Lys Gly
    210                 215                 220                 
Pro Val Phe Ala Pro Pro Tyr Glu Pro Leu Pro Glu Asn Val Lys Phe
225                 230                 235                 240 
Tyr Tyr Asp Gly Lys Val Met Lys Leu Ser Pro Lys Ala Glu Glu Val
                245                 250                 255     
Ala Thr Phe Phe Ala Lys Met Leu Asp His Glu Tyr Thr Thr Lys Glu
            260                 265                 270         
Ile Phe Arg Lys Asn Phe Phe Lys Asp Trp Arg Lys Glu Met Thr Asn
        275                 280                 285             
Glu Glu Lys Asn Ile Ile Thr Asn Leu Ser Lys Cys Asp Phe Thr Gln
    290                 295                 300                 
Met Ser Gln Tyr Phe Lys Ala Gln Thr Glu Ala Arg Lys Gln Met Ser
305                 310                 315                 320 
Lys Glu Glu Lys Leu Lys Ile Lys Glu Glu Asn Glu Lys Leu Leu Lys
                325                 330                 335     
Glu Tyr Gly Phe Cys Ile Met Asp Asn His Lys Glu Arg Ile Ala Asn
            340                 345                 350         
Phe Lys Ile Glu Pro Pro Gly Leu Phe Arg Gly Arg Gly Asn His Pro
        355                 360                 365             
Lys Met Gly Met Leu Lys Arg Arg Ile Met Pro Glu Asp Ile Ile Ile
    370                 375                 380                 
Asn Cys Ser Lys Asp Ala Lys Val Pro Ser Pro Pro Pro Gly His Lys
385                 390                 395                 400 
Trp Lys Glu Val Arg His Asp Asn Lys Val Thr Trp Leu Val Ser Trp
                405                 410                 415     
Thr Glu Asn Ile Gln Gly Ser Ile Lys Tyr Ile Met Leu Asn Pro Ser
            420                 425                 430         
Ser Arg Ile Lys Gly Glu Lys Asp Trp Gln Lys Tyr Glu Thr Ala Arg
        435                 440                 445             
Arg Leu Lys Lys Cys Val Asp Lys Ile Arg Asn Gln Tyr Arg Glu Asp
    450                 455                 460                 
Trp Lys Ser Lys Glu Met Lys Val Arg Gln Arg Ala Val Ala Leu Tyr
465                 470                 475                 480 
Phe Ile Asp Lys Leu Ala Leu Arg Ala Gly Asn Glu Lys Glu Glu Gly
                485                 490                 495     
Glu Thr Ala Asp Thr Val Gly Cys Cys Ser Leu Arg Val Glu His Ile
            500                 505                 510         
Asn Leu His Pro Glu Leu Asp Gly Gln Glu Tyr Val Val Glu Phe Asp
        515                 520                 525             
Phe Leu Gly Lys Asp Ser Ile Arg Tyr Tyr Asn Lys Val Pro Val Glu
    530                 535                 540                 
Lys Arg Val Phe Lys Asn Leu Gln Leu Phe Met Glu Asn Lys Gln Pro
545                 550                 555                 560 
Glu Asp Asp Leu Phe Asp Arg Leu Asn Thr Gly Ile Leu Asn Lys His
                565                 570                 575     
Leu Gln Asp Leu Met Glu Gly Leu Thr Ala Lys Val Phe Arg Thr Tyr
            580                 585                 590         
Asn Ala Ser Ile Thr Leu Gln Gln Gln Leu Lys Glu Leu Thr Ala Pro
        595                 600                 605             
Asp Glu Asn Ile Pro Ala Lys Ile Leu Ser Tyr Asn Arg Ala Asn Arg
    610                 615                 620                 
Ala Val Ala Ile Leu Cys Asn His Gln Arg Ala Pro Pro Lys Thr Phe
625                 630                 635                 640 
Glu Lys Ser Met Met Asn Leu Gln Thr Lys Ile Asp Ala Lys Lys Glu
                645                 650                 655     
Gln Leu Ala Asp Ala Arg Arg Asp Leu Lys Ser Ala Lys Ala Asp Ala
            660                 665                 670         
Lys Val Met Lys Asp Ala Lys Thr Lys Lys Val Val Glu Ser Lys Lys
        675                 680                 685             
Lys Ala Val Gln Arg Leu Glu Glu Gln Leu Met Lys Leu Glu Val Gln
    690                 695                 700                 
Ala Thr Asp Arg Glu Glu Asn Lys Gln Ile Ala Leu Gly Thr Ser Lys
705                 710                 715                 720 
Leu Asn Tyr Leu Asp Pro Arg Ile Thr Val Ala Trp Cys Lys Lys Trp
                725                 730                 735     
Gly Val Pro Ile Glu Lys Ile Tyr Asn Lys Thr Gln Arg Glu Lys Phe
            740                 745                 750         
Ala Trp Ala Ile Asp Met Ala Asp Glu Asp Tyr Glu Phe
        755                 760                 765 


<210> 1150
<211> 1165
<212> PRT
<213> Homo sapiens

<400> 1150
Met Gln Asp Val Gln Gly Pro Arg Pro Gly Ser Pro Gly Asp Ala Glu
 1               5                  10                  15      
Asp Arg Arg Glu Leu Gly Leu His Arg Gly Glu Val Asn Phe Gly Gly
            20                  25                  30          
Ser Gly Lys Lys Arg Gly Lys Phe Val Arg Val Pro Ser Gly Val Ala
        35                  40                  45              
Pro Ser Val Leu Phe Asp Leu Leu Leu Ala Glu Trp His Leu Pro Ala
    50                  55                  60                  
Pro Asn Leu Val Val Ser Leu Val Gly Glu Glu Gln Pro Phe Ala Met
65                  70                  75                  80  
Lys Ser Trp Leu Arg Asp Val Leu Arg Lys Gly Leu Val Lys Ala Ala
                85                  90                  95      
Gln Ser Thr Gly Ala Trp Ile Leu Thr Ser Ala Leu Arg Val Gly Leu
            100                 105                 110         
Ala Arg His Val Gly Gln Ala Val Arg Asp His Ser Leu Ala Ser Thr
        115                 120                 125             
Ser Thr Lys Val Arg Val Val Ala Val Gly Met Ala Ser Leu Gly Arg
    130                 135                 140                 
Val Leu His Arg Arg Ile Leu Glu Glu Ala Gln Glu Asp Phe Pro Val
145                 150                 155                 160 
His Tyr Pro Glu Asp Asp Gly Gly Ser Gln Gly Pro Leu Cys Ser Leu
                165                 170                 175     
Asp Ser Asn Leu Ser His Phe Ile Leu Val Glu Pro Gly Pro Pro Gly
            180                 185                 190         
Lys Gly Asp Gly Leu Thr Glu Leu Arg Leu Arg Leu Glu Lys His Ile
        195                 200                 205             
Ser Glu Gln Arg Ala Gly Tyr Gly Gly Thr Gly Ser Ile Glu Ile Pro
    210                 215                 220                 
Val Leu Cys Leu Leu Val Asn Gly Asp Pro Asn Thr Leu Glu Arg Ile
225                 230                 235                 240 
Ser Arg Ala Val Glu Gln Ala Ala Pro Trp Leu Ile Leu Val Gly Ser
                245                 250                 255     
Gly Gly Ile Ala Asp Val Leu Ala Ala Leu Val Asn Gln Pro His Leu
            260                 265                 270         
Leu Val Pro Lys Val Ala Glu Lys Gln Phe Lys Glu Lys Phe Pro Ser
        275                 280                 285             
Lys His Phe Ser Trp Glu Asp Ile Val Arg Trp Thr Lys Leu Leu Gln
    290                 295                 300                 
Asn Ile Thr Ser His Gln His Leu Leu Thr Val Tyr Asp Phe Glu Gln
305                 310                 315                 320 
Glu Gly Ser Glu Glu Leu Asp Thr Val Ile Leu Lys Ala Leu Val Lys
                325                 330                 335     
Ala Cys Lys Ser His Ser Gln Glu Pro Gln Asp Tyr Leu Asp Glu Leu
            340                 345                 350         
Lys Leu Ala Val Ala Trp Asp Arg Val Asp Ile Ala Lys Ser Glu Ile
        355                 360                 365             
Phe Asn Gly Asp Val Glu Trp Lys Ser Cys Asp Leu Glu Glu Val Met
    370                 375                 380                 
Val Asp Ala Leu Val Ser Asn Lys Pro Glu Phe Val Arg Leu Phe Val
385                 390                 395                 400 
Asp Asn Gly Ala Asp Val Ala Asp Phe Leu Thr Tyr Gly Arg Leu Gln
                405                 410                 415     
Glu Leu Tyr Arg Ser Val Ser Arg Lys Ser Leu Leu Phe Asp Leu Leu
            420                 425                 430         
Gln Arg Lys Gln Glu Glu Ala Arg Leu Thr Leu Ala Gly Leu Gly Thr
        435                 440                 445             
Gln Gln Ala Arg Glu Pro Pro Ala Gly Pro Pro Ala Phe Ser Leu His
    450                 455                 460                 
Glu Val Ser Arg Val Leu Lys Asp Phe Leu Gln Asp Ala Cys Arg Gly
465                 470                 475                 480 
Phe Tyr Gln Asp Gly Arg Pro Gly Asp Arg Arg Arg Ala Glu Lys Gly
                485                 490                 495     
Pro Ala Lys Arg Pro Thr Gly Gln Lys Trp Leu Leu Asp Leu Asn Gln
            500                 505                 510         
Lys Ser Glu Asn Pro Trp Arg Asp Leu Phe Leu Trp Ala Val Leu Gln
        515                 520                 525             
Asn Arg His Glu Met Ala Thr Tyr Phe Trp Ala Met Gly Gln Glu Gly
    530                 535                 540                 
Val Ala Ala Ala Leu Ala Ala Cys Lys Ile Leu Lys Glu Met Ser His
545                 550                 555                 560 
Leu Glu Thr Glu Ala Glu Ala Ala Arg Ala Thr Arg Glu Ala Lys Tyr
                565                 570                 575     
Glu Arg Leu Ala Leu Asp Leu Phe Ser Glu Cys Tyr Ser Asn Ser Glu
            580                 585                 590         
Ala Arg Ala Phe Ala Leu Leu Val Arg Arg Asn Arg Cys Trp Ser Lys
        595                 600                 605             
Thr Thr Cys Leu His Leu Ala Thr Glu Ala Asp Ala Lys Ala Phe Phe
    610                 615                 620                 
Ala His Asp Gly Val Gln Ala Phe Leu Thr Arg Ile Trp Trp Gly Asp
625                 630                 635                 640 
Met Ala Ala Gly Thr Pro Ile Leu Arg Leu Leu Gly Ala Phe Leu Cys
                645                 650                 655     
Pro Ala Leu Val Tyr Thr Asn Leu Ile Thr Phe Ser Glu Glu Ala Pro
            660                 665                 670         
Leu Arg Thr Gly Leu Glu Asp Leu Gln Asp Leu Asp Ser Leu Asp Thr
        675                 680                 685             
Glu Lys Ser Pro Leu Tyr Gly Leu Gln Ser Arg Val Glu Glu Leu Val
    690                 695                 700                 
Glu Ala Pro Arg Ala Gln Gly Asp Arg Gly Pro Arg Ala Val Phe Leu
705                 710                 715                 720 
Leu Thr Arg Trp Arg Lys Phe Trp Gly Ala Pro Val Thr Val Phe Leu
                725                 730                 735     
Gly Asn Val Val Met Tyr Phe Ala Phe Leu Phe Leu Phe Thr Tyr Val
            740                 745                 750         
Leu Leu Val Asp Phe Arg Pro Pro Pro Gln Gly Pro Ser Gly Pro Glu
        755                 760                 765             
Val Thr Leu Tyr Phe Trp Val Phe Thr Leu Val Leu Glu Glu Ile Arg
    770                 775                 780                 
Gln Gly Phe Phe Thr Asp Glu Asp Thr His Leu Val Lys Lys Phe Thr
785                 790                 795                 800 
Leu Tyr Val Gly Asp Asn Trp Asn Lys Cys Asp Met Val Ala Ile Phe
                805                 810                 815     
Leu Phe Ile Val Gly Val Thr Cys Arg Met Leu Pro Ser Ala Phe Glu
            820                 825                 830         
Ala Gly Arg Thr Val Leu Ala Met Asp Phe Met Val Phe Thr Leu Arg
        835                 840                 845             
Leu Ile His Ile Phe Ala Ile His Lys Gln Leu Gly Pro Lys Ile Ile
    850                 855                 860                 
Val Val Glu Arg Met Met Lys Asp Val Phe Phe Phe Leu Phe Phe Leu
865                 870                 875                 880 
Ser Val Trp Leu Val Ala Tyr Gly Val Thr Thr Gln Ala Leu Leu His
                885                 890                 895     
Pro His Asp Gly Arg Leu Glu Trp Ile Phe Arg Arg Val Leu Tyr Arg
            900                 905                 910         
Pro Tyr Leu Gln Ile Phe Gly Gln Ile Pro Leu Asp Glu Ile Asp Glu
        915                 920                 925             
Ala Arg Val Asn Cys Ser Thr His Pro Leu Leu Leu Glu Asp Ser Pro
    930                 935                 940                 
Ser Cys Pro Ser Leu Tyr Ala Asn Trp Leu Val Ile Leu Leu Leu Val
945                 950                 955                 960 
Thr Phe Leu Leu Val Thr Asn Val Leu Leu Met Asn Leu Leu Ile Ala
                965                 970                 975     
Met Phe Ser Tyr Thr Phe Gln Val Val Gln Gly Asn Ala Asp Met Phe
            980                 985                 990         
Trp Lys Phe Gln Arg Tyr Asn Leu Ile Val Glu Tyr His Glu Arg Pro
        995                 1000                1005            
Ala Leu Ala Pro Pro Phe Ile Leu Leu Ser His Leu Ser Leu Thr Leu
    1010                1015                1020                
Arg Arg Val Phe Lys Lys Glu Ala Glu His Lys Arg Glu His Leu Glu
1025                1030                1035                1040
Arg Asp Leu Pro Asp Pro Leu Asp Gln Lys Val Val Thr Trp Glu Thr
                1045                1050                1055    
Val Gln Lys Glu Asn Phe Leu Ser Lys Met Glu Lys Arg Arg Arg Asp
            1060                1065                1070        
Ser Glu Gly Glu Val Leu Arg Lys Thr Ala His Arg Val Asp Phe Ile
        1075                1080                1085            
Ala Lys Tyr Leu Gly Gly Leu Arg Glu Gln Glu Lys Arg Ile Lys Cys
    1090                1095                1100                
Leu Glu Ser Gln Ile Asn Tyr Cys Ser Val Leu Val Ser Ser Val Ala
1105                1110                1115                1120
Asp Val Leu Ala Gln Gly Gly Gly Pro Arg Ser Ser Gln His Cys Gly
                1125                1130                1135    
Glu Gly Ser Gln Leu Val Ala Ala Asp His Arg Gly Gly Leu Asp Gly
            1140                1145                1150        
Trp Glu Gln Pro Gly Ala Gly Gln Pro Pro Ser Asp Thr
        1155                1160                1165


<210> 1151
<211> 2041
<212> PRT
<213> Homo sapiens

<400> 1151
Met Asp Glu Val Glu Gln Asp Gln His Glu Ala Arg Leu Lys Glu Leu
 1               5                  10                  15      
Phe Asp Ser Phe Asp Thr Thr Gly Thr Gly Ser Leu Gly Gln Glu Glu
            20                  25                  30          
Leu Thr Asp Leu Cys His Met Leu Ser Leu Glu Glu Val Ala Pro Val
        35                  40                  45              
Leu Gln Gln Thr Leu Leu Gln Asp Asn Leu Leu Gly Arg Val His Phe
    50                  55                  60                  
Asp Gln Phe Lys Glu Ala Leu Ile Leu Ile Leu Ser Arg Thr Leu Ser
65                  70                  75                  80  
Asp Glu Glu His Phe Gln Glu Pro Asp Cys Ser Leu Glu Ala Gln Pro
                85                  90                  95      
Arg Tyr Val Arg Gly Glu Lys Pro Tyr Gly Arg Arg Ser Leu Pro Glu
            100                 105                 110         
Phe Gln Glu Ser Val Glu Glu Phe Pro Glu Val Thr Val Ile Glu Pro
        115                 120                 125             
Leu Asp Glu Glu Ala Arg Pro Ser His Ile Pro Ala Gly Asp Cys Ser
    130                 135                 140                 
Glu His Trp Lys Thr Gln Arg Ser Glu Glu Tyr Glu Ala Glu Gly Gln
145                 150                 155                 160 
Leu Arg Phe Trp Asn Pro Asp Asp Leu Asn Ala Ser Gln Ser Gly Ser
                165                 170                 175     
Ser Pro Pro Gln Asp Trp Ile Glu Glu Lys Leu Gln Gln Val Cys Glu
            180                 185                 190         
Asp Leu Gly Ile Thr Pro Asp Gly His Leu Asn Arg Lys Lys Leu Val
        195                 200                 205             
Ser Ile Cys Glu Gln Tyr Gly Leu Gln Asn Val Asp Gly Glu Met Leu
    210                 215                 220                 
Glu Glu Val Phe His Asn Leu Asp Pro Asp Gly Thr Met Ser Val Glu
225                 230                 235                 240 
Asp Phe Phe Tyr Gly Leu Phe Lys Asn Gly Lys Ser Leu Thr Pro Ser
                245                 250                 255     
Ala Ser Thr Pro Tyr Arg Gln Leu Lys Arg His Leu Ser Met Gln Ser
            260                 265                 270         
Phe Asp Glu Ser Gly Arg Arg Thr Thr Thr Ser Ser Ala Thr Thr Ser
        275                 280                 285             
Thr Ile Gly Phe Arg Val Phe Ser Cys Leu Asp Asp Gly Met Gly His
    290                 295                 300                 
Ala Ser Val Glu Arg Ile Leu Asp Thr Trp Gln Glu Glu Gly Ile Glu
305                 310                 315                 320 
Asn Ser Gln Glu Ile Leu Lys Ala Leu Asp Phe Ser Leu Asp Gly Asn
                325                 330                 335     
Ile Asn Leu Thr Glu Leu Thr Leu Ala Leu Glu Asn Glu Leu Leu Val
            340                 345                 350         
Thr Lys Asn Ser Ile His Gln Ala Ala Leu Ala Ser Phe Lys Ala Glu
        355                 360                 365             
Ile Arg His Leu Leu Glu Arg Val Asp Gln Val Val Arg Glu Lys Arg
    370                 375                 380                 
Ser Tyr Gly Gln Ile Trp Thr Ser Glu Lys Leu Lys Ser Leu Met Ala
385                 390                 395                 400 
Ser Glu Val Asp Asp His His Ala Ala Ile Glu Arg Arg Asn Glu Tyr
                405                 410                 415     
Asn Leu Arg Lys Leu Asp Glu Glu Tyr Lys Glu Arg Ile Ala Ala Leu
            420                 425                 430         
Lys Asn Glu Leu Arg Lys Glu Arg Glu Gln Ile Leu Gln Gln Ala Gly
        435                 440                 445             
Lys Gln Arg Leu Glu Leu Glu Gln Glu Ile Glu Lys Ala Lys Thr Glu
    450                 455                 460                 
Glu Asn Tyr Ile Arg Asp Arg Leu Ala Leu Ser Leu Lys Glu Asn Ser
465                 470                 475                 480 
Arg Leu Glu Asn Glu Leu Leu Glu Asn Ala Glu Lys Leu Ala Glu Tyr
                485                 490                 495     
Glu Asn Leu Thr Asn Lys Leu Gln Arg Asn Leu Glu Asn Val Leu Ala
            500                 505                 510         
Glu Lys Phe Gly Asp Leu Asp Pro Ser Ser Ala Glu Phe Phe Leu Gln
        515                 520                 525             
Glu Glu Arg Leu Thr Gln Met Arg Asn Glu Tyr Glu Arg Gln Cys Arg
    530                 535                 540                 
Val Leu Gln Asp Gln Val Asp Glu Leu Gln Ser Glu Leu Glu Glu Tyr
545                 550                 555                 560 
Arg Ala Gln Gly Arg Val Leu Arg Leu Pro Leu Lys Asn Ser Pro Ser
                565                 570                 575     
Glu Glu Val Glu Ala Asn Ser Gly Gly Ile Glu Pro Glu His Gly Leu
            580                 585                 590         
Gly Ser Glu Glu Cys Asn Pro Leu Asn Met Ser Ile Glu Ala Glu Leu
        595                 600                 605             
Val Ile Glu Gln Met Lys Glu Gln His His Arg Asp Ile Cys Cys Leu
    610                 615                 620                 
Arg Leu Glu Leu Glu Asp Lys Val Arg His Tyr Glu Lys Gln Leu Asp
625                 630                 635                 640 
Glu Thr Val Val Ser Cys Lys Lys Ala Gln Glu Asn Met Lys Gln Arg
                645                 650                 655     
His Glu Asn Glu Thr His Thr Leu Glu Glu Gln Ile Ser Asp Leu Lys
            660                 665                 670         
Met Lys Ile Ala Glu Leu Gln Gly Gln Ala Ala Val Leu Lys Glu Ala
        675                 680                 685             
His His Glu Ala Thr Cys Arg His Glu Glu Glu Lys Lys Gln Leu Gln
    690                 695                 700                 
Val Lys Leu Glu Glu Glu Lys Thr His Leu Gln Glu Lys Leu Arg Leu
705                 710                 715                 720 
Gln His Glu Met Glu Leu Lys Ala Arg Leu Thr Gln Ala Gln Ala Ser
                725                 730                 735     
Phe Gly Arg Glu Arg Glu Gly Leu Gln Ser Ser Ala Trp Thr Glu Glu
            740                 745                 750         
Lys Val Arg Gly Leu Thr Gln Glu Leu Glu Gln Phe His Gln Glu Gln
        755                 760                 765             
Leu Thr Ser Leu Val Glu Lys His Thr Leu Glu Lys Glu Glu Leu Arg
    770                 775                 780                 
Lys Glu Leu Leu Glu Lys His Gln Arg Glu Leu Gln Glu Gly Arg Glu
785                 790                 795                 800 
Lys Met Glu Thr Glu Cys Asn Arg Arg Thr Ser Gln Ile Glu Ala Gln
                805                 810                 815     
Phe Gln Ser Asp Cys Gln Lys Val Thr Glu Arg Cys Glu Ser Ala Leu
            820                 825                 830         
Gln Ser Leu Glu Gly Arg Tyr Arg Gln Glu Leu Lys Asp Leu Gln Glu
        835                 840                 845             
Gln Gln Arg Glu Glu Lys Ser Gln Trp Glu Phe Glu Lys Asp Glu Leu
    850                 855                 860                 
Thr Gln Glu Cys Ala Glu Ala Gln Glu Leu Leu Lys Glu Thr Leu Lys
865                 870                 875                 880 
Arg Glu Lys Thr Thr Ser Leu Val Leu Thr Gln Glu Arg Glu Met Leu
                885                 890                 895     
Glu Lys Thr Tyr Lys Asp His Leu Asn Ser Met Val Val Glu Arg Gln
            900                 905                 910         
Gln Leu Leu Gln Asp Leu Glu Asp Leu Arg Asn Val Ser Glu Thr Gln
        915                 920                 925             
Gln Ser Leu Leu Ser Asp Gln Ile Leu Glu Leu Lys Ser Ser His Lys
    930                 935                 940                 
Arg Glu Leu Arg Glu Arg Glu Glu Val Leu Cys Gln Gln Gly Val Ser
945                 950                 955                 960 
Glu Gln Leu Ala Ser Gln Arg Leu Glu Arg Leu Glu Met Glu His Asp
                965                 970                 975     
Gln Glu Arg Gln Glu Met Met Ser Lys Leu Leu Ala Met Glu Asn Ile
            980                 985                 990         
His Lys Ala Thr Cys Glu Thr Ala Asp Arg Glu Arg Ala Glu Met Ser
        995                 1000                1005            
Thr Glu Ile Ser Arg Leu Gln Ser Lys Ile Lys Glu Met Gln Gln Ala
    1010                1015                1020                
Thr Ser Pro Leu Ser Met Leu Gln Ser Gly Cys Gln Val Ile Gly Glu
1025                1030                1035                1040
Glu Glu Val Glu Gly Asp Gly Ala Leu Ser Leu Leu Gln Lys Gly Glu
                1045                1050                1055    
Gln Leu Leu Glu Glu Asn Gly Asp Val Leu Leu Ser Leu Gln Arg Ala
            1060                1065                1070        
His Glu Gln Ala Val Lys Glu Asn Val Lys Met Ala Thr Glu Ile Ser
        1075                1080                1085            
Arg Leu Gln Gln Arg Leu Gln Lys Leu Glu Pro Gly Leu Val Met Ser
    1090                1095                1100                
Ser Cys Leu Asp Glu Pro Ala Thr Glu Phe Phe Gly Asn Thr Ala Glu
1105                1110                1115                1120
Gln Thr Glu Pro Phe Leu Gln Gln Asn Arg Thr Lys Gln Val Glu Gly
                1125                1130                1135    
Val Thr Arg Arg His Val Leu Ser Asp Leu Glu Asp Asp Glu Val Arg
            1140                1145                1150        
Asp Leu Gly Ser Thr Gly Thr Ser Ser Val Gln Arg Gln Glu Val Lys
        1155                1160                1165            
Ile Glu Glu Ser Glu Ala Ser Val Glu Gly Phe Ser Glu Leu Glu Asn
    1170                1175                1180                
Ser Glu Glu Thr Arg Thr Glu Ser Trp Glu Leu Lys Asn His Ile Ser
1185                1190                1195                1200
Leu Leu Gln Glu Gln Leu Met Met Phe Cys Ala Asp Cys Asp Leu Ala
                1205                1210                1215    
Ser Glu Lys Lys Gln Glu Leu Leu Phe Asp Val Ser Val Leu Lys Lys
            1220                1225                1230        
Lys Leu Lys Ile Leu Glu Arg Ile Pro Glu Ala Ser Pro Arg Tyr Lys
        1235                1240                1245            
Leu Leu Tyr Glu Asp Val Ser Arg Glu Asn Asp Cys Leu Gln Glu Glu
    1250                1255                1260                
Leu Glu Met Met Glu Thr Arg Tyr Asp Glu Ala Leu Glu Asn Asn Lys
1265                1270                1275                1280
Glu Leu Thr Ala Glu Val Phe Arg Leu Gln Asp Glu Leu Lys Lys Met
                1285                1290                1295    
Glu Glu Val Thr Glu Thr Phe Leu Ser Leu Glu Lys Ser Tyr Asp Glu
            1300                1305                1310        
Val Lys Ile Glu Asn Glu Glu Leu Asn Val Leu Val Leu Arg Leu Gln
        1315                1320                1325            
Gly Lys Ile Glu Lys Leu His Glu Ser Val Val Lys Arg Cys Asp Cys
    1330                1335                1340                
Cys Leu Trp Glu Gly Ser Leu Glu Asn Leu Glu Ile Glu Pro Asp Gly
1345                1350                1355                1360
Asn Ile Leu Gln Leu Asn Gln Thr Leu Glu Glu Cys Val Pro Arg Val
                1365                1370                1375    
Arg Ser Val His His Val Ile Glu Glu Cys Lys Gln Glu Asn Gln Tyr
            1380                1385                1390        
Leu Glu Gly Asn Thr Gln Leu Leu Glu Lys Val Lys Ala His Glu Ile
        1395                1400                1405            
Ala Trp Phe His Gly Thr Ile Gln Thr His His Glu Arg Pro Arg Val
    1410                1415                1420                
Gln Asn Gln Phe Ile Leu Glu Glu Asn Thr Thr Leu Leu Gly Phe Gln
1425                1430                1435                1440
Asn Lys His Phe Gln His Gln Ala Thr Leu Pro Asn Leu Glu Leu Glu
                1445                1450                1455    
Lys Gln Asn Phe Gln Glu Leu Thr Arg Asn Leu Arg Glu Lys Phe Pro
            1460                1465                1470        
Ile Leu Ile Tyr Gln Lys Asn Phe Leu Ser Pro Gly Lys Lys Glu Glu
        1475                1480                1485            
Glu Leu Lys Ala Met Met His Asp Leu Gln Ile Pro Cys Ser Glu Met
    1490                1495                1500                
Gln Gln Lys Val Glu Leu Leu Lys Tyr Glu Ser Glu Lys Leu His Gln
1505                1510                1515                1520
Glu Asn Ser Phe Leu Arg Asn Glu Ile Thr Thr Leu Asn Glu Glu Asp
                1525                1530                1535    
Ser Ile Ser Asn Leu Lys Leu Gly Thr Leu Asn Gly Ser Gln Glu Glu
            1540                1545                1550        
Met Trp Gln Lys Thr Glu Ser Val Lys Gln Glu Asn Ala Ala Val Leu
        1555                1560                1565            
Lys Met Val Glu Asn Leu Lys Lys Gln Ile Ser Glu Leu Lys Ile Lys
    1570                1575                1580                
Asn Gln Gln Leu Asp Leu Glu Asn Thr Glu Leu Ser Gln Lys Asn Ser
1585                1590                1595                1600
Pro Asn Gln Glu Lys Leu Gln Glu Leu Asn Gln Leu Leu Thr Glu Met
                1605                1610                1615    
Leu Cys Gln Lys Glu Lys Glu Pro Gly Asn Ser Ala Leu Glu Glu Arg
            1620                1625                1630        
Glu Gln Glu Lys Phe Asn Leu Lys Glu Glu Pro Glu Arg Cys Lys Val
        1635                1640                1645            
Gln Ser Ser Thr Leu Val Ser Ser Leu Glu Ala Glu Leu Ser Glu Val
    1650                1655                1660                
Asn Tyr Arg Thr Pro Ile Val Gln Gln Glu Asn Pro Leu Leu Gln Asp
1665                1670                1675                1680
Glu Leu Glu Lys Met Lys Gln Leu His Arg Cys Pro Asp Leu Ser Asn
                1685                1690                1695    
Phe Gln Gln Lys Ile Ser Ser Val Leu Ser Tyr Asn Glu Lys Leu Leu
            1700                1705                1710        
Lys Glu Lys Glu Ala Leu Ser Glu Glu Leu Asn Ser Cys Val Asp Lys
        1715                1720                1725            
Leu Ala Lys Ser Ser Leu Leu Glu His Arg Ile Ala Thr Met Lys Gln
    1730                1735                1740                
Glu Gln Lys Ser Trp Glu His Gln Ser Ala Ser Leu Lys Thr Gln Leu
1745                1750                1755                1760
Val Ala Ser Gln Glu Lys Val Gln Asn Leu Glu Asp Thr Val Gln Asn
                1765                1770                1775    
Val Asn Leu Gln Met Ser Arg Met Lys Ser Asp Pro Arg Val Thr Gln
            1780                1785                1790        
Gln Glu Lys Glu Ala Leu Lys Gln Glu Val Met Pro Leu His Lys Gln
        1795                1800                1805            
Leu Gln Asn Ser Val Ala Arg Ala Gly Pro Arg Glu Ile Asp His Pro
    1810                1815                1820                
Ser Gly Phe His Asn Gln Gln Lys Arg Leu Ser Trp Asp Lys Leu Asp
1825                1830                1835                1840
Tyr Leu Met Asn Glu Glu Gln Gln Leu Phe Cys Lys Glu Asn Glu Arg
                1845                1850                1855    
Phe Gln Thr Met Val Gln Asn Thr Lys Ala Glu Leu Thr His Ser Arg
            1860                1865                1870        
Glu Lys Phe Arg Gln Leu Glu Ser Asn Leu Leu Pro Lys His Gln Lys
        1875                1880                1885            
Tyr Leu Asn Pro Ser Gly Thr Met Asn Pro Thr Glu Gln Glu Lys Leu
    1890                1895                1900                
Ser Leu Lys Arg Glu Cys Asp Gln Phe Gln Lys Glu Gln Ser Pro Ala
1905                1910                1915                1920
Asn Arg Lys Val Ser Gln Met Asn Ser Leu Glu Gln Glu Leu Lys Thr
                1925                1930                1935    
Ile His Leu Glu Asn Glu Gly Leu Lys Lys Lys Gln Val Lys Leu Asp
            1940                1945                1950        
Glu Gln Leu Met Glu Met Gln His Leu Arg Ser Thr Ala Thr Pro Ser
        1955                1960                1965            
Pro Ser Pro His Ala Trp Asp Leu Gln Leu Leu Gln Gln Gln Ala Cys
    1970                1975                1980                
Arg Met Val Pro Arg Glu Gln Phe Leu Arg Phe Lys Pro Gln Leu Leu
1985                1990                1995                2000
Gln Ala Glu Arg Ile Ser Gln His Leu Gln Gly Glu Phe Glu Asn Arg
                2005                2010                2015    
Thr Ser Glu Thr Asn Thr Pro Arg Gly Asn Arg Glu Gln Leu Val Thr
            2020                2025                2030        
Val Met Gly Gly Thr Asn Asp Arg Ser
        2035                2040    


<210> 1152
<211> 438
<212> PRT
<213> Homo sapiens

<400> 1152
Met Ala Leu Arg Gly Val Ser Val Arg Leu Leu Ser Arg Gly Pro Gly
 1               5                  10                  15      
Leu His Val Leu Arg Thr Trp Val Ser Ser Ala Ala Gln Thr Glu Lys
            20                  25                  30          
Ala Gly Arg Thr Gln Ser Gln Leu Ala Lys Ser Ser Arg Pro Glu Phe
        35                  40                  45              
Asp Trp Gln Asp Pro Leu Val Leu Glu Glu Gln Leu Thr Thr Asp Glu
    50                  55                  60                  
Ile Leu Ile Arg Asp Thr Phe Arg Thr Tyr Cys Gln Glu Arg Leu Met
65                  70                  75                  80  
Pro Arg Ile Leu Leu Ala Asn Arg Asn Glu Val Phe His Arg Glu Ile
                85                  90                  95      
Ile Ser Glu Met Gly Glu Leu Gly Val Leu Gly Pro Thr Ile Lys Gly
            100                 105                 110         
Tyr Gly Cys Ala Gly Val Ser Ser Val Ala Tyr Gly Leu Leu Ala Arg
        115                 120                 125             
Glu Leu Glu Arg Val Asp Ser Gly Tyr Arg Ser Ala Met Ser Val Gln
    130                 135                 140                 
Ser Ser Leu Val Met His Pro Ile Tyr Ala Tyr Gly Ser Glu Glu Gln
145                 150                 155                 160 
Arg Gln Lys Tyr Leu Pro Gln Leu Ala Lys Gly Glu Leu Leu Gly Cys
                165                 170                 175     
Phe Gly Leu Thr Glu Pro Asn Ser Gly Ser Asp Pro Ser Ser Met Glu
            180                 185                 190         
Thr Arg Ala His Tyr Asn Ser Ser Asn Lys Ser Tyr Thr Leu Asn Gly
        195                 200                 205             
Thr Lys Thr Trp Ile Thr Asn Ser Pro Met Ala Asp Leu Phe Val Val
    210                 215                 220                 
Trp Ala Arg Cys Glu Asp Gly Cys Ile Arg Gly Phe Leu Leu Glu Lys
225                 230                 235                 240 
Gly Met Arg Gly Leu Ser Ala Pro Arg Ile Gln Gly Lys Phe Ser Leu
                245                 250                 255     
Arg Ala Ser Ala Thr Gly Met Ile Ile Met Asp Gly Val Glu Val Pro
            260                 265                 270         
Glu Glu Asn Val Leu Pro Gly Ala Ser Ser Leu Gly Gly Pro Phe Gly
        275                 280                 285             
Cys Leu Asn Asn Ala Arg Tyr Gly Ile Ala Trp Gly Val Leu Gly Ala
    290                 295                 300                 
Ser Glu Phe Cys Leu His Thr Ala Arg Gln Tyr Ala Leu Asp Arg Met
305                 310                 315                 320 
Gln Phe Gly Val Pro Leu Ala Arg Asn Gln Leu Ile Gln Lys Lys Leu
                325                 330                 335     
Ala Asp Met Leu Thr Glu Ile Thr Leu Gly Leu His Ala Cys Leu Gln
            340                 345                 350         
Leu Gly Arg Leu Lys Asp Gln Asp Lys Ala Ala Pro Glu Met Val Ser
        355                 360                 365             
Leu Leu Lys Arg Asn Asn Cys Gly Lys Ala Leu Asp Ile Ala Arg Gln
    370                 375                 380                 
Ala Arg Asp Met Leu Gly Gly Asn Gly Ile Ser Asp Glu Tyr His Val
385                 390                 395                 400 
Ile Arg His Ala Met Asn Leu Glu Ala Val Asn Thr Tyr Glu Gly Thr
                405                 410                 415     
His Asp Ile His Ala Leu Ile Leu Gly Arg Ala Ile Thr Gly Ile Gln
            420                 425                 430         
Ala Phe Thr Ala Ser Lys
        435             


<210> 1153
<211> 438
<212> PRT
<213> Homo sapiens

<400> 1153
Met Ala Leu Arg Gly Val Ser Val Arg Leu Leu Ser Arg Gly Pro Gly
 1               5                  10                  15      
Leu His Val Leu Arg Thr Trp Val Ser Ser Ala Ala Gln Thr Glu Lys
            20                  25                  30          
Ala Gly Arg Thr Gln Ser Gln Leu Ala Lys Ser Ser Arg Pro Glu Phe
        35                  40                  45              
Asp Trp Gln Asp Pro Leu Val Leu Glu Glu Gln Leu Thr Thr Asp Glu
    50                  55                  60                  
Ile Leu Ile Arg Asp Thr Phe Arg Thr Tyr Cys Gln Glu Arg Leu Met
65                  70                  75                  80  
Pro Arg Ile Leu Leu Ala Asn Arg Asn Glu Val Phe His Arg Glu Ile
                85                  90                  95      
Ile Ser Glu Met Gly Glu Leu Gly Val Leu Gly Pro Thr Ile Lys Gly
            100                 105                 110         
Tyr Gly Cys Ala Gly Val Ser Ser Val Ala Tyr Gly Leu Leu Ala Arg
        115                 120                 125             
Glu Leu Glu Arg Val Asp Ser Gly Tyr Arg Ser Ala Met Ser Val Gln
    130                 135                 140                 
Ser Ser Leu Val Met His Pro Ile Tyr Ala Tyr Gly Ser Glu Glu Gln
145                 150                 155                 160 
Arg Gln Lys Tyr Leu Pro Gln Leu Ala Lys Gly Glu Leu Leu Gly Cys
                165                 170                 175     
Phe Gly Leu Thr Glu Pro Asn Ser Gly Ser Asp Pro Ser Ser Met Glu
            180                 185                 190         
Thr Arg Ala His Tyr Asn Ser Ser Asn Lys Ser Tyr Thr Leu Asn Gly
        195                 200                 205             
Thr Lys Thr Trp Ile Thr Asn Ser Pro Met Ala Asp Leu Phe Val Val
    210                 215                 220                 
Trp Ala Arg Cys Glu Asp Gly Cys Ile Arg Gly Phe Leu Leu Glu Lys
225                 230                 235                 240 
Gly Met Arg Gly Leu Ser Ala Pro Arg Ile Gln Gly Lys Phe Ser Leu
                245                 250                 255     
Arg Ala Ser Ala Thr Gly Met Ile Ile Met Asp Gly Val Glu Val Pro
            260                 265                 270         
Glu Glu Asn Val Leu Pro Gly Ala Ser Ser Leu Gly Gly Pro Phe Gly
        275                 280                 285             
Cys Leu Asn Asn Ala Arg Tyr Gly Ile Ala Trp Gly Val Leu Gly Ala
    290                 295                 300                 
Ser Glu Phe Cys Leu His Thr Ala Arg Gln Tyr Ala Leu Asp Arg Met
305                 310                 315                 320 
Gln Phe Gly Val Pro Leu Ala Arg Asn Gln Leu Ile Gln Lys Lys Leu
                325                 330                 335     
Ala Asp Met Leu Thr Glu Ile Thr Leu Gly Leu His Ala Cys Leu Gln
            340                 345                 350         
Leu Gly Arg Leu Lys Asp Gln Asp Lys Ala Ala Pro Glu Met Val Ser
        355                 360                 365             
Leu Leu Lys Arg Asn Asn Cys Gly Lys Ala Leu Asp Ile Ala Arg Gln
    370                 375                 380                 
Ala Arg Asp Met Leu Gly Gly Asn Gly Ile Ser Asp Glu Tyr His Val
385                 390                 395                 400 
Ile Arg His Ala Met Asn Leu Glu Ala Val Asn Thr Tyr Glu Gly Thr
                405                 410                 415     
His Asp Ile His Ala Leu Ile Leu Gly Arg Ala Ile Thr Gly Ile Gln
            420                 425                 430         
Ala Phe Thr Ala Ser Lys
        435             


<210> 1154
<211> 819
<212> PRT
<213> Homo sapiens

<400> 1154
Met Ala Glu Val Glu Asp Gln Ala Ala Arg Asp Met Lys Arg Leu Glu
 1               5                  10                  15      
Glu Lys Asp Lys Glu Arg Lys Asn Val Lys Gly Ile Arg Asp Asp Ile
            20                  25                  30          
Glu Glu Glu Asp Asp Gln Glu Ala Tyr Phe Arg Tyr Met Ala Glu Asn
        35                  40                  45              
Pro Thr Ala Gly Val Val Gln Glu Glu Glu Glu Asp Asn Leu Glu Tyr
    50                  55                  60                  
Asp Ser Asp Gly Asn Pro Ile Ala Pro Thr Lys Lys Ile Ile Asp Pro
65                  70                  75                  80  
Leu Pro Pro Ile Asp His Ser Glu Ile Asp Tyr Pro Pro Phe Glu Lys
                85                  90                  95      
Asn Phe Tyr Asn Glu His Glu Glu Ile Thr Asn Leu Thr Pro Gln Gln
            100                 105                 110         
Leu Ile Asp Leu Arg His Lys Leu Asn Leu Arg Val Ser Gly Ala Ala
        115                 120                 125             
Pro Pro Arg Pro Gly Ser Ser Phe Ala His Phe Gly Phe Asp Glu Gln
    130                 135                 140                 
Leu Met His Gln Ile Arg Lys Ser Glu Tyr Thr Gln Pro Thr Pro Ile
145                 150                 155                 160 
Gln Cys Gln Gly Val Pro Val Ala Leu Ser Gly Arg Asp Met Ile Gly
                165                 170                 175     
Ile Ala Lys Thr Gly Ser Gly Lys Thr Ala Ala Phe Ile Trp Pro Met
            180                 185                 190         
Leu Ile His Ile Met Asp Gln Lys Glu Leu Glu Pro Gly Asp Gly Pro
        195                 200                 205             
Ile Ala Val Ile Val Cys Pro Thr Arg Glu Leu Cys Gln Gln Ile His
    210                 215                 220                 
Ala Glu Cys Lys Arg Phe Gly Lys Ala Tyr Asn Leu Arg Ser Val Ala
225                 230                 235                 240 
Val Tyr Gly Gly Gly Ser Met Trp Glu Gln Ala Lys Ala Leu Gln Glu
                245                 250                 255     
Gly Ala Glu Ile Val Val Cys Thr Pro Gly Arg Leu Ile Asp His Val
            260                 265                 270         
Lys Lys Lys Ala Thr Asn Leu Gln Arg Val Ser Tyr Leu Val Phe Asp
        275                 280                 285             
Glu Ala Asp Arg Met Phe Asp Met Gly Phe Glu Tyr Gln Val Arg Ser
    290                 295                 300                 
Ile Ala Ser His Val Arg Pro Asp Arg Gln Thr Leu Leu Phe Ser Ala
305                 310                 315                 320 
Thr Phe Arg Lys Lys Ile Glu Lys Leu Ala Arg Asp Ile Leu Ile Asp
                325                 330                 335     
Pro Ile Arg Val Val Gln Gly Asp Ile Gly Glu Ala Asn Glu Asp Val
            340                 345                 350         
Thr Gln Ile Val Glu Ile Leu His Ser Gly Pro Ser Lys Trp Asn Trp
        355                 360                 365             
Leu Thr Arg Arg Leu Val Glu Phe Thr Ser Ser Gly Ser Val Leu Leu
    370                 375                 380                 
Phe Val Thr Lys Lys Ala Asn Ala Glu Glu Leu Ala Asn Asn Leu Lys
385                 390                 395                 400 
Gln Glu Gly His Asn Leu Gly Leu Leu His Gly Asp Met Asp Gln Ser
                405                 410                 415     
Glu Arg Asn Lys Val Ile Ser Asp Phe Lys Lys Lys Asp Ile Pro Val
            420                 425                 430         
Leu Val Ala Thr Asp Val Ala Ala Arg Gly Leu Asp Ile Pro Ser Ile
        435                 440                 445             
Lys Thr Val Ile Asn Tyr Asp Val Ala Arg Asp Ile Asp Thr His Thr
    450                 455                 460                 
His Arg Ile Gly Arg Thr Gly Arg Ala Gly Glu Lys Gly Val Ala Tyr
465                 470                 475                 480 
Thr Leu Leu Thr Pro Lys Asp Ser Asn Phe Ala Gly Asp Leu Val Arg
                485                 490                 495     
Asn Leu Glu Gly Ala Asn Gln His Val Ser Lys Glu Leu Leu Asp Leu
            500                 505                 510         
Ala Met Gln Asn Ala Trp Phe Arg Lys Ser Arg Phe Lys Gly Gly Lys
        515                 520                 525             
Gly Lys Lys Leu Asn Ile Gly Gly Gly Gly Leu Gly Tyr Arg Glu Arg
    530                 535                 540                 
Pro Gly Leu Gly Ser Glu Asn Met Asp Arg Gly Asn Asn Asn Val Met
545                 550                 555                 560 
Ser Asn Tyr Glu Ala Tyr Lys Pro Ser Thr Gly Ala Met Gly Asp Arg
                565                 570                 575     
Leu Thr Ala Met Lys Ala Ala Phe Gln Ser Gln Tyr Lys Ser His Phe
            580                 585                 590         
Val Ala Ala Ser Leu Ser Asn Gln Lys Ala Gly Ser Ser Ala Ala Gly
        595                 600                 605             
Ala Ser Gly Trp Thr Ser Ala Gly Ser Leu Asn Ser Val Pro Thr Asn
    610                 615                 620                 
Ser Ala Gln Gln Gly His Asn Ser Pro Asp Ser Pro Val Thr Ser Ala
625                 630                 635                 640 
Ala Lys Gly Ile Pro Gly Phe Gly Asn Thr Gly Asn Ile Ser Gly Ala
                645                 650                 655     
Pro Val Thr Tyr Pro Ser Ala Gly Ala Gln Gly Val Asn Asn Thr Ala
            660                 665                 670         
Ser Gly Asn Asn Ser Arg Glu Gly Thr Gly Gly Ser Asn Gly Lys Arg
        675                 680                 685             
Glu Arg Tyr Thr Glu Asn Arg Gly Ser Ser Arg His Ser His Gly Glu
    690                 695                 700                 
Thr Gly Asn Arg His Ser Asp Ser Pro Arg His Gly Asp Gly Gly Arg
705                 710                 715                 720 
His Gly Asp Gly Tyr Arg His Pro Glu Ser Ser Ser Arg His Thr Asp
                725                 730                 735     
Gly His Arg His Gly Glu Asn Arg His Gly Gly Ser Ala Gly Arg His
            740                 745                 750         
Gly Glu Asn Arg Gly Ala Asn Asp Gly Arg Asn Gly Glu Ser Arg Lys
        755                 760                 765             
Glu Ala Phe Asn Arg Glu Ser Lys Met Glu Pro Lys Met Glu Pro Lys
    770                 775                 780                 
Val Asp Ser Ser Lys Met Asp Lys Val Asp Ser Lys Thr Asp Lys Thr
785                 790                 795                 800 
Ala Asp Gly Phe Ala Val Pro Glu Pro Pro Lys Arg Lys Lys Ser Arg
                805                 810                 815     
Trp Asp Ser
            


<210> 1155
<211> 1594
<212> PRT
<213> Homo sapiens

<400> 1155
Met Gly Ala Pro Ser Ala Cys Arg Thr Leu Val Leu Ala Leu Ala Ala
 1               5                  10                  15      
Met Leu Val Val Pro Gln Ala Glu Thr Gln Gly Pro Val Glu Pro Ser
            20                  25                  30          
Trp Gly Asn Ala Gly His Thr Met Asp Gly Gly Ala Pro Thr Ser Ser
        35                  40                  45              
Pro Thr Arg Arg Val Ser Phe Val Pro Pro Val Thr Val Phe Pro Ser
    50                  55                  60                  
Leu Ser Pro Leu Asn Pro Ala His Asn Gly Arg Val Cys Ser Thr Trp
65                  70                  75                  80  
Gly Asp Phe His Tyr Lys Thr Phe Asp Gly Asp Val Phe Arg Phe Pro
                85                  90                  95      
Gly Leu Cys Asn Tyr Val Phe Ser Glu His Cys Arg Ala Ala Tyr Glu
            100                 105                 110         
Asp Phe Asn Val Gln Leu Arg Arg Gly Leu Val Gly Ser Arg Pro Val
        115                 120                 125             
Val Thr Arg Val Val Ile Lys Ala Gln Gly Leu Val Leu Lys Ala Ser
    130                 135                 140                 
Asn Gly Ser Val Leu Ile Asn Gly Gln Arg Glu Glu Leu Pro Tyr Ser
145                 150                 155                 160 
Arg Thr Gly Leu Leu Val Glu Gln Ser Gly Asp Tyr Ile Lys Val Ser
                165                 170                 175     
Ile Arg Leu Val Leu Thr Phe Leu Trp Asn Gly Glu Asp Ser Ala Leu
            180                 185                 190         
Leu Glu Leu Asp Pro Lys Tyr Ala Asn Gln Thr Cys Gly Leu Cys Gly
        195                 200                 205             
Asp Phe Asn Gly Leu Pro Ala Phe Asn Glu Phe Tyr Ala His Asn Ala
    210                 215                 220                 
Arg Leu Thr Pro Leu Gln Phe Gly Asn Leu Gln Lys Leu Asp Gly Pro
225                 230                 235                 240 
Thr Glu Gln Cys Pro Asp Pro Leu Pro Leu Pro Ala Gly Asn Cys Thr
                245                 250                 255     
Asp Glu Glu Gly Ile Cys His Arg Thr Leu Leu Gly Pro Ala Phe Ala
            260                 265                 270         
Glu Cys His Ala Leu Val Asp Ser Thr Ala Tyr Leu Ala Ala Cys Ala
        275                 280                 285             
Gln Asp Leu Cys Arg Cys Pro Thr Cys Pro Cys Ala Thr Phe Val Glu
    290                 295                 300                 
Tyr Ser Arg Gln Cys Ala His Ala Gly Gly Gln Pro Arg Asn Trp Arg
305                 310                 315                 320 
Cys Pro Glu Leu Cys Pro Arg Thr Cys Pro Leu Asn Met Gln His Gln
                325                 330                 335     
Glu Cys Gly Ser Pro Cys Thr Asp Thr Cys Ser Asn Pro Gln Arg Ala
            340                 345                 350         
Gln Leu Cys Glu Asp His Cys Val Asp Gly Cys Phe Cys Pro Pro Gly
        355                 360                 365             
Ser Thr Val Leu Asp Asp Ile Thr His Ser Gly Cys Leu Pro Leu Gly
    370                 375                 380                 
Gln Cys Pro Cys Thr His Gly Gly Arg Thr Tyr Ser Pro Gly Thr Ser
385                 390                 395                 400 
Phe Asn Thr Thr Cys Ser Ser Cys Thr Cys Ser Gly Gly Leu Trp Gln
                405                 410                 415     
Cys Gln Asp Leu Pro Cys Pro Gly Thr Cys Ser Val Gln Gly Gly Ala
            420                 425                 430         
His Ile Ser Thr Tyr Asp Glu Lys Leu Tyr Asp Leu His Gly Asp Cys
        435                 440                 445             
Ser Tyr Val Leu Ser Lys Lys Cys Ala Asp Ser Ser Phe Thr Val Leu
    450                 455                 460                 
Ala Glu Leu Arg Lys Cys Gly Leu Thr Asp Asn Glu Asn Cys Leu Lys
465                 470                 475                 480 
Ala Val Thr Leu Ser Leu Asp Gly Gly Asp Thr Ala Ile Arg Val Gln
                485                 490                 495     
Ala Asp Gly Gly Val Phe Leu Asn Ser Ile Tyr Thr Gln Leu Pro Leu
            500                 505                 510         
Ser Ala Ala Asn Ile Thr Leu Phe Thr Pro Ser Ser Phe Phe Ile Val
        515                 520                 525             
Val Gln Thr Gly Leu Gly Leu Gln Leu Leu Val Gln Leu Val Pro Leu
    530                 535                 540                 
Met Gln Val Phe Val Arg Leu Asp Pro Ala His Gln Gly Gln Met Cys
545                 550                 555                 560 
Gly Leu Cys Gly Asn Phe Asn Gln Asn Gln Ala Asp Asp Phe Thr Ala
                565                 570                 575     
Leu Ser Gly Val Val Glu Ala Thr Gly Ala Ala Phe Ala Asn Thr Trp
            580                 585                 590         
Lys Ala Gln Ala Ala Cys Ala Asn Ala Arg Asn Ser Phe Glu Asp Pro
        595                 600                 605             
Cys Ser Leu Ser Val Glu Asn Glu Asn Tyr Ala Arg His Trp Cys Ser
    610                 615                 620                 
Arg Leu Thr Asp Pro Asn Ser Ala Phe Ser Arg Cys His Ser Ile Ile
625                 630                 635                 640 
Asn Pro Lys Pro Phe His Ser Asn Cys Met Phe Asp Thr Cys Asn Cys
                645                 650                 655     
Glu Arg Ser Glu Asp Cys Leu Cys Ala Ala Leu Ser Ser Tyr Val His
            660                 665                 670         
Ala Cys Ala Ala Lys Gly Val Gln Leu Ser Asp Trp Arg Asp Gly Val
        675                 680                 685             
Cys Thr Lys Tyr Met Gln Asn Cys Pro Lys Ser Gln Arg Tyr Ala Tyr
    690                 695                 700                 
Val Val Asp Ala Cys Gln Pro Thr Cys Arg Gly Leu Ser Glu Ala Asp
705                 710                 715                 720 
Val Thr Cys Ser Val Ser Phe Val Pro Val Asp Gly Cys Thr Cys Pro
                725                 730                 735     
Ala Gly Thr Phe Leu Asn Asp Ala Gly Ala Cys Val Pro Ala Gln Glu
            740                 745                 750         
Cys Pro Cys Tyr Ala His Gly Thr Val Leu Ala Pro Gly Glu Val Val
        755                 760                 765             
His Asp Glu Gly Ala Val Cys Ser Cys Thr Gly Gly Lys Leu Ser Cys
    770                 775                 780                 
Leu Gly Ala Ser Leu Gln Lys Ser Thr Gly Cys Ala Ala Pro Met Val
785                 790                 795                 800 
Tyr Leu Asp Cys Ser Asn Ser Ser Ala Gly Thr Pro Gly Ala Glu Cys
                805                 810                 815     
Leu Arg Ser Cys His Thr Leu Asp Val Gly Cys Phe Ser Thr His Cys
            820                 825                 830         
Val Ser Gly Cys Val Cys Pro Pro Gly Leu Val Ser Asp Gly Ser Gly
        835                 840                 845             
Gly Cys Ile Ala Glu Glu Asp Cys Pro Cys Val His Asn Glu Ala Thr
    850                 855                 860                 
Tyr Lys Pro Gly Glu Thr Ile Arg Val Asp Cys Asn Thr Cys Thr Cys
865                 870                 875                 880 
Arg Asn Arg Arg Trp Glu Cys Ser His Arg Leu Cys Leu Gly Thr Cys
                885                 890                 895     
Val Ala Tyr Gly Asp Gly His Phe Ile Thr Phe Asp Gly Asp Arg Tyr
            900                 905                 910         
Ser Phe Glu Gly Ser Cys Glu Tyr Ile Leu Ala Gln Asp Tyr Cys Gly
        915                 920                 925             
Asp Asn Thr Thr His Gly Thr Phe Arg Ile Val Thr Glu Asn Ile Pro
    930                 935                 940                 
Cys Gly Thr Thr Gly Thr Thr Cys Ser Lys Ala Ile Lys Leu Phe Val
945                 950                 955                 960 
Glu Ser Tyr Glu Leu Ile Leu Gln Glu Gly Thr Phe Lys Ala Val Ala
                965                 970                 975     
Arg Gly Pro Gly Gly Asp Pro Pro Tyr Lys Ile Arg Tyr Met Gly Ile
            980                 985                 990         
Phe Leu Val Ile Glu Thr His Gly Met Ala Val Ser Trp Asp Arg Lys
        995                 1000                1005            
Thr Ser Val Phe Ile Arg Leu His Gln Asp Tyr Lys Gly Arg Val Cys
    1010                1015                1020                
Gly Leu Cys Gly Asn Phe Asp Asp Asn Ala Ile Asn Asp Phe Ala Thr
1025                1030                1035                1040
Arg Ser Arg Ser Val Val Gly Asp Ala Leu Glu Phe Gly Asn Ser Trp
                1045                1050                1055    
Lys Leu Ser Pro Ser Cys Pro Asp Ala Leu Ala Pro Lys Asp Pro Cys
            1060                1065                1070        
Thr Ala Asn Pro Phe Arg Lys Ser Trp Ala Gln Lys Gln Cys Ser Ile
        1075                1080                1085            
Leu His Gly Pro Thr Phe Ala Ala Cys Arg Ser Gln Val Asp Ser Thr
    1090                1095                1100                
Lys Tyr Tyr Glu Ala Cys Val Asn Asp Ala Cys Ala Cys Asp Ser Gly
1105                1110                1115                1120
Gly Asp Cys Glu Cys Phe Cys Thr Ala Val Ala Ala Tyr Ala Gln Ala
                1125                1130                1135    
Cys His Asp Ala Gly Leu Cys Val Ser Trp Arg Thr Pro Asp Thr Cys
            1140                1145                1150        
Pro Leu Phe Cys Asp Phe Tyr Asn Pro His Gly Gly Cys Glu Trp His
        1155                1160                1165            
Tyr Gln Pro Cys Gly Ala Pro Cys Leu Lys Thr Cys Arg Asn Pro Ser
    1170                1175                1180                
Gly His Cys Leu Val Asp Leu Pro Gly Leu Glu Gly Cys Tyr Pro Lys
1185                1190                1195                1200
Cys Pro Pro Ser Gln Pro Phe Phe Asn Glu Asp Gln Met Lys Cys Val
                1205                1210                1215    
Ala Gln Cys Gly Cys Tyr Asp Lys Asp Gly Asn Tyr Tyr Asp Val Gly
            1220                1225                1230        
Ala Arg Val Pro Thr Ala Glu Asn Cys Gln Ser Cys Asn Cys Thr Pro
        1235                1240                1245            
Ser Gly Ile Gln Cys Ala His Ser Leu Glu Ala Cys Thr Cys Thr Tyr
    1250                1255                1260                
Glu Asp Arg Thr Tyr Ser Tyr Gln Asp Val Ile Tyr Asn Thr Thr Asp
1265                1270                1275                1280
Gly Leu Gly Ala Cys Leu Ile Ala Ile Cys Gly Ser Asn Gly Thr Ile
                1285                1290                1295    
Ile Arg Lys Ala Val Ala Cys Pro Gly Thr Pro Ala Thr Thr Pro Phe
            1300                1305                1310        
Thr Phe Thr Thr Ala Trp Val Pro His Ser Thr Thr Ser Pro Ala Leu
        1315                1320                1325            
Pro Val Ser Thr Val Cys Val Arg Glu Val Cys Arg Trp Ser Ser Trp
    1330                1335                1340                
Tyr Asn Gly His Arg Pro Glu Pro Gly Leu Gly Gly Gly Asp Phe Glu
1345                1350                1355                1360
Thr Phe Glu Asn Leu Arg Gln Arg Gly Tyr Gln Val Cys Pro Val Leu
                1365                1370                1375    
Ala Asp Ile Glu Cys Arg Ala Ala Gln Leu Pro Asp Met Pro Leu Glu
            1380                1385                1390        
Glu Leu Gly Gln Gln Val Asp Cys Asp Arg Met Arg Gly Leu Met Cys
        1395                1400                1405            
Ala Asn Ser Gln Gln Ser Pro Pro Leu Cys His Asp Tyr Glu Leu Arg
    1410                1415                1420                
Val Leu Cys Cys Glu Tyr Val Pro Cys Gly Pro Ser Pro Ala Pro Gly
1425                1430                1435                1440
Thr Ser Pro Gln Pro Ser Leu Ser Ala Ser Thr Glu Pro Ala Val Pro
                1445                1450                1455    
Thr Pro Thr Gln Thr Thr Ala Thr Glu Lys Thr Thr Leu Trp Val Thr
            1460                1465                1470        
Pro Ser Ile Arg Ser Thr Ala Ala Leu Thr Ser Gln Thr Gly Ser Ser
        1475                1480                1485            
Ser Gly Pro Val Thr Val Thr Pro Ser Ala Pro Gly Thr Thr Thr Cys
    1490                1495                1500                
Gln Pro Arg Cys Gln Trp Thr Glu Trp Phe Asp Glu Asp Tyr Pro Lys
1505                1510                1515                1520
Ser Glu Gln Leu Gly Gly Asp Val Glu Ser Tyr Asp Lys Ile Arg Ala
                1525                1530                1535    
Ala Gly Gly His Leu Cys Gln Gln Pro Lys Asp Ile Glu Cys Gln Ala
            1540                1545                1550        
Glu Ser Phe Pro Asn Trp Thr Leu Ala Gln Val Gly Gln Lys Val His
        1555                1560                1565            
Cys Asp Val His Phe Gly Leu Val Cys Arg Asn Trp Glu Gln Glu Gly
    1570                1575                1580                
Val Phe Lys Met Cys Tyr Asn Tyr Arg Ile
1585                1590                


<210> 1156
<211> 601
<212> PRT
<213> Homo sapiens

<400> 1156
Met Lys Leu Asp Ile Glu Gln Tyr Arg Met Val Lys Glu Ala Leu His
 1               5                  10                  15      
Glu Arg Ala Asn Leu Leu Glu Ile Ala Pro His Leu Ser Ala Pro Leu
            20                  25                  30          
Pro Ile Met Leu Pro Val Tyr Lys Trp Trp Gln Leu Pro Tyr Tyr Trp
        35                  40                  45              
Val Gly Ile Lys Leu Tyr Asp Leu Val Ala Gly Ser Asn Cys Leu Lys
    50                  55                  60                  
Ser Ser Tyr Val Leu Ser Lys Ser Arg Ala Leu Glu His Phe Pro Met
65                  70                  75                  80  
Leu Gln Lys Asp Lys Leu Val Gly Ala Ile Val Tyr Tyr Asp Gly Gln
                85                  90                  95      
His Asn Asp Ala Arg Met Asn Leu Ala Ile Ala Leu Thr Ala Ala Arg
            100                 105                 110         
Tyr Gly Ala Ala Thr Ala Asn Tyr Met Glu Val Val Ser Leu Leu Lys
        115                 120                 125             
Lys Thr Asp Pro Gln Thr Gly Lys Val His Val Ser Gly Ala Arg Cys
    130                 135                 140                 
Lys Asp Val Leu Thr Gly Gln Glu Phe Asp Val Arg Ala Lys Cys Val
145                 150                 155                 160 
Ile Asn Ala Thr Gly Pro Phe Thr Asp Ser Val Arg Lys Met Asp Asp
                165                 170                 175     
Lys Asp Ala Ala Ala Ile Cys Gln Pro Ser Ala Gly Val His Ile Val
            180                 185                 190         
Met Pro Gly Tyr Tyr Ser Pro Glu Ser Met Gly Leu Leu Asp Pro Ala
        195                 200                 205             
Thr Ser Asp Gly Arg Val Ile Phe Phe Leu Pro Trp Gln Lys Met Thr
    210                 215                 220                 
Ile Ala Gly Thr Thr Asp Thr Pro Thr Asp Val Thr His His Pro Ile
225                 230                 235                 240 
Pro Ser Glu Glu Asp Ile Asn Phe Ile Leu Asn Glu Val Arg Asn Tyr
                245                 250                 255     
Leu Ser Cys Asp Val Glu Val Arg Arg Gly Asp Val Leu Ala Ala Trp
            260                 265                 270         
Ser Gly Ile Arg Pro Leu Val Thr Asp Pro Lys Ser Ala Asp Thr Gln
        275                 280                 285             
Ser Ile Ser Arg Asn His Val Val Asp Ile Ser Glu Ser Gly Leu Ile
    290                 295                 300                 
Thr Ile Ala Gly Gly Lys Trp Thr Thr Tyr Arg Ser Met Ala Glu Asp
305                 310                 315                 320 
Thr Ile Asn Ala Ala Val Lys Thr His Asn Leu Lys Ala Gly Pro Ser
                325                 330                 335     
Arg Thr Val Gly Leu Phe Leu Gln Gly Gly Lys Asp Trp Ser Pro Thr
            340                 345                 350         
Leu Tyr Ile Arg Leu Val Gln Asp Tyr Gly Leu Glu Ser Glu Val Ala
        355                 360                 365             
Gln His Leu Ala Ala Thr Tyr Gly Asp Lys Ala Phe Glu Val Ala Lys
    370                 375                 380                 
Met Ala Ser Val Thr Gly Lys Arg Trp Pro Ile Val Gly Val His Leu
385                 390                 395                 400 
Val Ser Glu Phe Pro Tyr Ile Glu Ala Glu Val Lys Tyr Gly Ile Lys
                405                 410                 415     
Glu Tyr Ala Cys Thr Ala Val Asp Met Ile Ser Arg Arg Thr Arg Leu
            420                 425                 430         
Ala Phe Leu Asn Val Gln Ala Ala Glu Glu Ala Leu Pro Arg Ile Val
        435                 440                 445             
Glu Leu Met Gly Arg Glu Leu Asn Trp Asp Asp Tyr Lys Lys Gln Glu
    450                 455                 460                 
Gln Leu Glu Thr Ala Arg Lys Phe Leu Tyr Tyr Glu Met Gly Tyr Lys
465                 470                 475                 480 
Ser Arg Ser Glu Gln Leu Thr Asp Arg Ser Glu Ile Ser Leu Leu Pro
                485                 490                 495     
Ser Asp Ile Asp Arg Tyr Lys Lys Arg Phe His Lys Phe Asp Ala Asp
            500                 505                 510         
Gln Lys Gly Phe Ile Thr Ile Val Asp Val Gln Arg Val Leu Glu Ser
        515                 520                 525             
Ile Asn Val Gln Met Asp Glu Asn Thr Leu His Glu Ile Leu Asn Glu
    530                 535                 540                 
Val Asp Leu Asn Lys Asn Gly Gln Val Glu Leu Asn Glu Phe Leu Gln
545                 550                 555                 560 
Leu Met Ser Ala Ile Gln Lys Gly Arg Val Ser Gly Ser Arg Leu Ala
                565                 570                 575     
Ile Leu Met Lys Thr Ala Glu Glu Asn Leu Asp Arg Arg Val Pro Ile
            580                 585                 590         
Pro Val Asp Arg Ser Cys Gly Gly Leu
        595                 600     


<210> 1157
<211> 698
<212> PRT
<213> Homo sapiens

<400> 1157
Met Gln Ala His Glu Leu Phe Arg Tyr Phe Arg Met Pro Glu Leu Val
 1               5                  10                  15      
Asp Phe Arg Gln Tyr Val Arg Thr Leu Pro Thr Asn Thr Leu Met Gly
            20                  25                  30          
Phe Gly Ala Phe Ala Ala Leu Thr Thr Phe Trp Tyr Ala Thr Arg Pro
        35                  40                  45              
Lys Pro Leu Lys Pro Pro Cys Asp Leu Ser Met Gln Ser Val Glu Val
    50                  55                  60                  
Ala Gly Ser Gly Gly Ala Arg Arg Ser Ala Leu Leu Asp Ser Asp Glu
65                  70                  75                  80  
Pro Leu Val Tyr Phe Tyr Asp Asp Val Thr Thr Leu Tyr Glu Gly Phe
                85                  90                  95      
Gln Arg Gly Ile Gln Val Ser Asn Asn Gly Pro Cys Leu Gly Ser Arg
            100                 105                 110         
Lys Pro Asp Gln Pro Tyr Glu Trp Leu Ser Tyr Lys Gln Val Ala Glu
        115                 120                 125             
Leu Ser Glu Cys Ile Gly Ser Ala Leu Ile Gln Lys Gly Phe Lys Thr
    130                 135                 140                 
Ala Pro Asp Gln Phe Ile Gly Ile Phe Ala Gln Asn Arg Pro Glu Trp
145                 150                 155                 160 
Val Ile Ile Glu Gln Gly Cys Phe Ala Tyr Ser Met Val Ile Val Pro
                165                 170                 175     
Leu Tyr Asp Thr Leu Gly Asn Glu Ala Ile Thr Tyr Ile Val Asn Lys
            180                 185                 190         
Ala Glu Leu Ser Leu Val Phe Val Asp Lys Pro Glu Lys Ala Lys Leu
        195                 200                 205             
Leu Leu Glu Gly Val Glu Asn Lys Leu Ile Pro Gly Leu Lys Ile Ile
    210                 215                 220                 
Val Val Met Asp Ala Tyr Gly Ser Glu Leu Val Glu Arg Gly Gln Arg
225                 230                 235                 240 
Cys Gly Val Glu Val Thr Ser Met Lys Ala Met Glu Asp Leu Gly Arg
                245                 250                 255     
Ala Asn Arg Arg Lys Pro Lys Pro Pro Ala Pro Glu Asp Leu Ala Val
            260                 265                 270         
Ile Cys Phe Thr Ser Gly Thr Thr Gly Asn Pro Lys Gly Ala Met Val
        275                 280                 285             
Thr His Arg Asn Ile Val Ser Asp Cys Ser Ala Phe Val Lys Ala Thr
    290                 295                 300                 
Glu Asn Thr Val Asn Pro Cys Pro Asp Asp Thr Leu Ile Ser Phe Leu
305                 310                 315                 320 
Pro Leu Ala His Met Phe Glu Arg Val Val Glu Cys Val Met Leu Cys
                325                 330                 335     
His Gly Ala Lys Ile Gly Phe Phe Gln Gly Asp Ile Arg Leu Leu Met
            340                 345                 350         
Asp Asp Leu Lys Val Leu Gln Pro Thr Val Phe Pro Val Val Pro Arg
        355                 360                 365             
Leu Leu Asn Arg Met Phe Asp Arg Ile Phe Gly Gln Ala Asn Thr Thr
    370                 375                 380                 
Leu Lys Arg Trp Leu Leu Asp Phe Ala Ser Lys Arg Lys Glu Ala Glu
385                 390                 395                 400 
Leu Arg Ser Gly Ile Ile Arg Asn Asn Ser Leu Trp Asp Arg Leu Ile
                405                 410                 415     
Phe His Lys Val Gln Ser Ser Leu Gly Gly Arg Val Arg Leu Met Val
            420                 425                 430         
Thr Gly Ala Ala Pro Val Ser Ala Thr Val Leu Thr Phe Leu Arg Ala
        435                 440                 445             
Ala Leu Gly Cys Gln Phe Tyr Glu Gly Tyr Gly Gln Thr Glu Cys Thr
    450                 455                 460                 
Ala Gly Cys Cys Leu Thr Met Pro Gly Asp Trp Thr Ala Gly His Val
465                 470                 475                 480 
Gly Ala Pro Met Pro Cys Asn Leu Ile Lys Leu Val Asp Val Glu Glu
                485                 490                 495     
Met Asn Tyr Met Ala Ala Glu Gly Glu Gly Glu Val Cys Val Lys Gly
            500                 505                 510         
Pro Asn Val Phe Gln Gly Tyr Leu Lys Asp Pro Ala Lys Thr Ala Glu
        515                 520                 525             
Ala Leu Asp Lys Asp Gly Trp Leu His Thr Gly Asp Ile Gly Lys Trp
    530                 535                 540                 
Leu Pro Asn Gly Thr Leu Lys Ile Ile Asp Arg Lys Lys His Ile Phe
545                 550                 555                 560 
Lys Leu Ala Gln Gly Glu Tyr Ile Ala Pro Glu Lys Ile Glu Asn Ile
                565                 570                 575     
Tyr Met Arg Ser Glu Pro Val Ala Gln Val Phe Val His Gly Glu Ser
            580                 585                 590         
Leu Gln Ala Phe Leu Ile Ala Ile Val Val Pro Asp Val Glu Thr Leu
        595                 600                 605             
Cys Ser Trp Ala Gln Lys Arg Gly Phe Glu Gly Ser Phe Glu Glu Leu
    610                 615                 620                 
Cys Arg Asn Lys Asp Val Lys Lys Ala Ile Leu Glu Asp Met Val Arg
625                 630                 635                 640 
Leu Gly Lys Asp Ser Gly Leu Lys Pro Phe Glu Gln Val Lys Gly Ile
                645                 650                 655     
Thr Leu His Pro Glu Leu Phe Ser Ile Asp Asn Gly Leu Leu Thr Pro
            660                 665                 670         
Thr Met Lys Ala Lys Arg Pro Glu Leu Arg Asn Tyr Phe Arg Ser Gln
        675                 680                 685             
Ile Asp Asp Leu Tyr Ser Thr Ile Lys Val
    690                 695             


<210> 1158
<211> 698
<212> PRT
<213> Homo sapiens

<400> 1158
Met Gln Ala His Glu Leu Phe Arg Tyr Phe Arg Met Pro Glu Leu Val
 1               5                  10                  15      
Asp Phe Arg Gln Tyr Val Arg Thr Leu Pro Thr Asn Thr Leu Met Gly
            20                  25                  30          
Phe Gly Ala Phe Ala Ala Leu Thr Thr Phe Trp Tyr Ala Thr Arg Pro
        35                  40                  45              
Lys Pro Leu Lys Pro Pro Cys Asp Leu Ser Met Gln Ser Val Glu Val
    50                  55                  60                  
Ala Gly Ser Gly Gly Ala Arg Arg Ser Ala Leu Leu Asp Ser Asp Glu
65                  70                  75                  80  
Pro Leu Val Tyr Phe Tyr Asp Asp Val Thr Thr Leu Tyr Glu Gly Phe
                85                  90                  95      
Gln Arg Gly Ile Gln Val Ser Asn Asn Gly Pro Cys Leu Gly Ser Arg
            100                 105                 110         
Lys Pro Asp Gln Pro Tyr Glu Trp Leu Ser Tyr Lys Gln Val Ala Glu
        115                 120                 125             
Leu Ser Glu Cys Ile Gly Ser Ala Leu Ile Gln Lys Gly Phe Lys Thr
    130                 135                 140                 
Ala Pro Asp Gln Phe Ile Gly Ile Phe Ala Gln Asn Arg Pro Glu Trp
145                 150                 155                 160 
Val Ile Ile Glu Gln Gly Cys Phe Ala Tyr Ser Met Val Ile Val Pro
                165                 170                 175     
Leu Tyr Asp Thr Leu Gly Asn Glu Ala Ile Thr Tyr Ile Val Asn Lys
            180                 185                 190         
Ala Glu Leu Ser Leu Val Phe Val Asp Lys Pro Glu Lys Ala Lys Leu
        195                 200                 205             
Leu Leu Glu Gly Val Glu Asn Lys Leu Ile Pro Gly Leu Lys Ile Ile
    210                 215                 220                 
Val Val Met Asp Ala Tyr Gly Ser Glu Leu Val Glu Arg Gly Gln Arg
225                 230                 235                 240 
Cys Gly Val Glu Val Thr Ser Met Lys Ala Met Glu Asp Leu Gly Arg
                245                 250                 255     
Ala Asn Arg Arg Lys Pro Lys Pro Pro Ala Pro Glu Asp Leu Ala Val
            260                 265                 270         
Ile Cys Phe Thr Ser Gly Thr Thr Gly Asn Pro Lys Gly Ala Met Val
        275                 280                 285             
Thr His Arg Asn Ile Val Ser Asp Cys Ser Ala Phe Val Lys Ala Thr
    290                 295                 300                 
Glu Asn Thr Val Asn Pro Cys Pro Asp Asp Thr Leu Ile Ser Phe Leu
305                 310                 315                 320 
Pro Leu Ala His Met Phe Glu Arg Val Val Glu Cys Val Met Leu Cys
                325                 330                 335     
His Gly Ala Lys Ile Gly Phe Phe Gln Gly Asp Ile Arg Leu Leu Met
            340                 345                 350         
Asp Asp Leu Lys Val Leu Gln Pro Thr Val Phe Pro Val Val Pro Arg
        355                 360                 365             
Leu Leu Asn Arg Met Phe Asp Arg Ile Phe Gly Gln Ala Asn Thr Thr
    370                 375                 380                 
Leu Lys Arg Trp Leu Leu Asp Phe Ala Ser Lys Arg Lys Glu Ala Glu
385                 390                 395                 400 
Leu Arg Ser Gly Ile Ile Arg Asn Asn Ser Leu Trp Asp Arg Leu Ile
                405                 410                 415     
Phe His Lys Val Gln Ser Ser Leu Gly Gly Arg Val Arg Leu Met Val
            420                 425                 430         
Thr Gly Ala Ala Pro Val Ser Ala Thr Val Leu Thr Phe Leu Arg Ala
        435                 440                 445             
Ala Leu Gly Cys Gln Phe Tyr Glu Gly Tyr Gly Gln Thr Glu Cys Thr
    450                 455                 460                 
Ala Gly Cys Cys Leu Thr Met Pro Gly Asp Trp Thr Ala Gly His Val
465                 470                 475                 480 
Gly Ala Pro Met Pro Cys Asn Leu Ile Lys Leu Val Asp Val Glu Glu
                485                 490                 495     
Met Asn Tyr Met Ala Ala Glu Gly Glu Gly Glu Val Cys Val Lys Gly
            500                 505                 510         
Pro Asn Val Phe Gln Gly Tyr Leu Lys Asp Pro Ala Lys Thr Ala Glu
        515                 520                 525             
Ala Leu Asp Lys Asp Gly Trp Leu His Thr Gly Asp Ile Gly Lys Trp
    530                 535                 540                 
Leu Pro Asn Gly Thr Leu Lys Ile Ile Asp Arg Lys Lys His Ile Phe
545                 550                 555                 560 
Lys Leu Ala Gln Gly Glu Tyr Ile Ala Pro Glu Lys Ile Glu Asn Ile
                565                 570                 575     
Tyr Met Arg Ser Glu Pro Val Ala Gln Val Phe Val His Gly Glu Ser
            580                 585                 590         
Leu Gln Ala Phe Leu Ile Ala Ile Val Val Pro Asp Val Glu Thr Leu
        595                 600                 605             
Cys Ser Trp Ala Gln Lys Arg Gly Phe Glu Gly Ser Phe Glu Glu Leu
    610                 615                 620                 
Cys Arg Asn Lys Asp Val Lys Lys Ala Ile Leu Glu Asp Met Val Arg
625                 630                 635                 640 
Leu Gly Lys Asp Ser Gly Leu Lys Pro Phe Glu Gln Val Lys Gly Ile
                645                 650                 655     
Thr Leu His Pro Glu Leu Phe Ser Ile Asp Asn Gly Leu Leu Thr Pro
            660                 665                 670         
Thr Met Lys Ala Lys Arg Pro Glu Leu Arg Asn Tyr Phe Arg Ser Gln
        675                 680                 685             
Ile Asp Asp Leu Tyr Ser Thr Ile Lys Val
    690                 695             


<210> 1159
<211> 115
<212> PRT
<213> Homo sapiens

<400> 1159
Met Thr Lys Lys Arg Arg Asn Asn Gly Arg Ala Lys Lys Gly Arg Gly
 1               5                  10                  15      
His Val Gln Pro Ile Arg Cys Thr Asn Cys Ala Arg Cys Val Pro Lys
            20                  25                  30          
Asp Lys Ala Ile Lys Lys Phe Val Ile Arg Asn Ile Val Glu Ala Ala
        35                  40                  45              
Ala Val Arg Asp Ile Ser Glu Ala Ser Val Phe Asp Ala Tyr Val Leu
    50                  55                  60                  
Pro Lys Leu Tyr Val Lys Leu His Tyr Cys Val Ser Cys Ala Ile His
65                  70                  75                  80  
Ser Lys Val Val Arg Asn Arg Ser Arg Glu Ala Arg Lys Asp Arg Thr
                85                  90                  95      
Pro Pro Pro Arg Phe Arg Pro Ala Gly Ala Ala Pro Ala Pro Pro Pro
            100                 105                 110         
Lys Pro Met
        115 


<210> 1160
<211> 630
<212> PRT
<213> Homo sapiens

<400> 1160
Gly Arg Val Gly Gly Arg Val Gly Ala Ala Gly Ser Thr Arg Ser Thr
 1               5                  10                  15      
Ala Gly Ala Gly Leu Gly Gln Arg Leu Arg Cys Cys Trp Ile Val Val
            20                  25                  30          
Phe Ser Gly Ile Glu Asp Thr His Gln Lys Pro Lys Met Pro Lys Pro
        35                  40                  45              
Ile Asn Val Arg Val Thr Thr Met Asp Ala Glu Leu Glu Phe Ala Ile
    50                  55                  60                  
Gln Pro Asn Thr Thr Gly Lys Gln Leu Phe Asp Gln Val Val Lys Thr
65                  70                  75                  80  
Ile Gly Leu Arg Glu Val Trp Tyr Phe Gly Leu His Tyr Val Asp Asn
                85                  90                  95      
Lys Gly Phe Pro Thr Trp Leu Lys Leu Asp Lys Lys Val Ser Ala Gln
            100                 105                 110         
Glu Val Arg Lys Glu Asn Pro Leu Gln Phe Lys Phe Arg Ala Lys Phe
        115                 120                 125             
Tyr Pro Glu Asp Val Ala Glu Glu Leu Ile Gln Asp Ile Thr Gln Lys
    130                 135                 140                 
Leu Phe Phe Leu Gln Val Lys Glu Gly Ile Leu Ser Asp Glu Ile Tyr
145                 150                 155                 160 
Cys Pro Pro Glu Thr Ala Val Leu Leu Gly Ser Tyr Ala Val Gln Ala
                165                 170                 175     
Lys Phe Gly Asp Tyr Asn Lys Glu Val His Lys Ser Gly Tyr Leu Ser
            180                 185                 190         
Ser Glu Arg Leu Ile Pro Gln Arg Val Met Asp Gln His Lys Leu Thr
        195                 200                 205             
Arg Asp Gln Trp Glu Asp Arg Ile Gln Val Trp His Ala Glu His Arg
    210                 215                 220                 
Gly Met Leu Lys Asp Asn Ala Met Leu Glu Tyr Leu Lys Ile Ala Gln
225                 230                 235                 240 
Asp Leu Glu Met Tyr Gly Ile Asn Tyr Phe Glu Ile Lys Asn Lys Lys
                245                 250                 255     
Gly Thr Asp Leu Trp Leu Gly Val Asp Ala Leu Gly Leu Asn Ile Tyr
            260                 265                 270         
Glu Lys Asp Asp Lys Leu Thr Pro Lys Ile Gly Phe Pro Trp Ser Glu
        275                 280                 285             
Ile Arg Asn Ile Ser Phe Asn Asp Lys Lys Phe Val Ile Lys Pro Ile
    290                 295                 300                 
Asp Lys Lys Ala Pro Asp Phe Val Phe Tyr Ala Pro Arg Leu Arg Ile
305                 310                 315                 320 
Asn Lys Arg Ile Leu Gln Leu Cys Met Gly Asn His Glu Leu Tyr Met
                325                 330                 335     
Arg Arg Arg Lys Pro Asp Thr Ile Glu Val Gln Gln Met Lys Ala Gln
            340                 345                 350         
Ala Arg Glu Glu Lys His Gln Lys Gln Leu Glu Arg Gln Gln Leu Glu
        355                 360                 365             
Thr Glu Lys Lys Arg Arg Glu Thr Val Glu Arg Glu Lys Glu Gln Met
    370                 375                 380                 
Met Arg Glu Lys Glu Glu Leu Met Leu Arg Leu Gln Asp Tyr Glu Glu
385                 390                 395                 400 
Lys Thr Lys Lys Ala Glu Arg Glu Leu Ser Glu Gln Ile Gln Arg Ala
                405                 410                 415     
Leu Gln Leu Glu Glu Glu Arg Lys Arg Ala Gln Glu Glu Ala Glu Arg
            420                 425                 430         
Leu Glu Ala Asp Arg Met Ala Ala Leu Arg Ala Lys Glu Glu Leu Glu
        435                 440                 445             
Arg Gln Ala Val Asp Gln Ile Lys Ser Gln Glu Gln Leu Ala Ala Glu
    450                 455                 460                 
Leu Ala Glu Tyr Thr Ala Lys Ile Ala Leu Leu Glu Glu Ala Arg Arg
465                 470                 475                 480 
Arg Lys Glu Asp Glu Val Glu Glu Trp Gln His Arg Ala Lys Glu Ala
                485                 490                 495     
Gln Asp Asp Leu Val Lys Thr Lys Glu Glu Leu His Leu Val Met Thr
            500                 505                 510         
Ala Pro Pro Pro Pro Pro Pro Pro Val Tyr Glu Pro Val Ser Tyr His
        515                 520                 525             
Val Gln Glu Ser Leu Gln Asp Glu Gly Ala Glu Pro Thr Gly Tyr Ser
    530                 535                 540                 
Ala Glu Leu Ser Ser Glu Gly Ile Arg Asp Asp Arg Asn Glu Glu Lys
545                 550                 555                 560 
Arg Ile Thr Glu Ala Glu Lys Asn Glu Arg Val Gln Arg Gln Leu Leu
                565                 570                 575     
Thr Leu Ser Ser Glu Leu Ser Gln Ala Arg Asp Glu Asn Lys Arg Thr
            580                 585                 590         
His Asn Asp Ile Ile His Asn Glu Asn Met Arg Gln Gly Arg Asp Lys
        595                 600                 605             
Tyr Lys Thr Leu Arg Gln Ile Arg Gln Gly Asn Thr Lys Gln Arg Ile
    610                 615                 620                 
Asp Glu Phe Glu Ala Leu
625                 630 


<210> 1161
<211> 737
<212> PRT
<213> Homo sapiens

<400> 1161
Met Pro Glu Glu Val His His Gly Glu Glu Glu Val Glu Thr Phe Ala
 1               5                  10                  15      
Phe Gln Ala Glu Ile Ala Gln Leu Met Ser Leu Ile Ile Asn Thr Phe
            20                  25                  30          
Tyr Ser Asn Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ala Ser
        35                  40                  45              
Asp Ala Leu Asp Lys Ile Arg Tyr Glu Ser Leu Thr Asp Pro Ser Lys
    50                  55                  60                  
Leu Asp Ser Gly Lys Glu Leu Lys Ile Asp Ile Ile Pro Asn Pro Gln
65                  70                  75                  80  
Glu Arg Thr Leu Thr Leu Val Asp Thr Gly Ile Gly Met Thr Lys Ala
                85                  90                  95      
Asp Leu Ile Asn Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Lys Ala
            100                 105                 110         
Phe Met Glu Ala Leu Gln Ala Gly Ala Asp Ile Ser Met Ile Gly Gln
        115                 120                 125             
Phe Gly Val Gly Phe Tyr Ser Ala Tyr Leu Val Ala Glu Lys Val Val
    130                 135                 140                 
Val Ile Thr Lys His Asn Asp Asp Glu Gln Tyr Ala Trp Glu Ser Ser
145                 150                 155                 160 
Ala Gly Gly Ser Phe Thr Val Arg Ala Asp His Gly Glu Pro Ile Gly
                165                 170                 175     
Arg Gly Thr Lys Val Ile Leu His Leu Lys Glu Asp Gln Thr Glu Tyr
            180                 185                 190         
Leu Glu Glu Arg Arg Val Lys Glu Val Val Lys Lys His Ser Gln Phe
        195                 200                 205             
Ile Gly Tyr Pro Ile Thr Leu Tyr Leu Glu Lys Glu Arg Glu Lys Glu
    210                 215                 220                 
Ile Ser Asp Asp Glu Ala Glu Glu Glu Lys Gly Glu Lys Glu Glu Glu
225                 230                 235                 240 
Asp Lys Asp Asp Glu Glu Lys Pro Lys Ile Glu Asp Val Gly Ser Asp
                245                 250                 255     
Glu Glu Asp Asp Ser Gly Lys Asp Lys Lys Lys Lys Thr Lys Lys Ile
            260                 265                 270         
Lys Glu Lys Tyr Ile Asp Gln Glu Glu Leu Asn Lys Thr Lys Pro Ile
        275                 280                 285             
Trp Thr Arg Asn Pro Asp Asp Ile Thr Gln Glu Glu Tyr Gly Glu Phe
    290                 295                 300                 
Tyr Lys Ser Leu Thr Asn Asp Trp Glu Asp His Leu Ala Val Lys His
305                 310                 315                 320 
Phe Ser Val Glu Gly Gln Leu Glu Phe Arg Ala Leu Leu Phe Ile Pro
                325                 330                 335     
Arg Arg Ala Pro Phe Asp Leu Phe Glu Asn Lys Lys Lys Lys Asn Asn
            340                 345                 350         
Ile Lys Leu Tyr Val Arg Arg Val Phe Ile Met Asp Ser Cys Asp Glu
        355                 360                 365             
Leu Ile Pro Glu Tyr Leu Asn Phe Ile Arg Gly Val Val Asp Ser Glu
    370                 375                 380                 
Asp Leu Pro Leu Asn Ile Ser Arg Glu Met Leu Gln Gln Ser Lys Ile
385                 390                 395                 400 
Leu Lys Ala Ile Arg Lys Asn Ile Val Lys Lys Cys Leu Glu Leu Phe
                405                 410                 415     
Ser Glu Leu Ala Glu Asp Lys Glu Asn Tyr Lys Lys Phe Tyr Glu Ala
            420                 425                 430         
Phe Ser Lys Asn Leu Lys Leu Gly Ile His Glu Asp Ser Thr Asn Arg
        435                 440                 445             
Arg Arg Leu Ser Glu Leu Leu Arg Tyr His Thr Ser Gln Ser Gly Asp
    450                 455                 460                 
Glu Met Thr Ser Leu Ser Glu Tyr Val Ser Arg Met Lys Glu Thr Gln
465                 470                 475                 480 
Lys Ser Ile Tyr Tyr Ile Thr Gly Glu Ser Lys Glu Gln Val Ala Asn
                485                 490                 495     
Ser Ala Phe Val Glu Arg Val Arg Lys Arg Gly Phe Glu Val Val Tyr
            500                 505                 510         
Met Thr Glu Pro Ile Asp Glu Tyr Cys Val Gln Gln Leu Lys Glu Phe
        515                 520                 525             
Asp Gly Lys Ser Leu Val Ser Val Thr Lys Glu Gly Leu Glu Leu Pro
    530                 535                 540                 
Glu Asp Glu Glu Glu Lys Lys Lys Met Glu Glu Ser Lys Ala Lys Phe
545                 550                 555                 560 
Glu Asn Leu Cys Lys Leu Met Lys Glu Ile Leu Asp Lys Lys Val Glu
                565                 570                 575     
Lys Val Thr Ile Ser Asn Arg Leu Val Ser Ser Pro Cys Cys Ile Val
            580                 585                 590         
Thr Ser Thr Tyr Gly Trp Thr Ala Asn Met Glu Arg Ile Met Lys Ala
        595                 600                 605             
Gln Ala Leu Arg Asp Asn Ser Thr Met Gly Tyr Met Met Ala Lys Lys
    610                 615                 620                 
His Leu Glu Ile Asn Pro Asp His Pro Ile Val Glu Thr Leu Arg Gln
625                 630                 635                 640 
Lys Ala Glu Ala Asp Lys Asn Asp Lys Ala Val Lys Asp Leu Val Val
                645                 650                 655     
Leu Leu Phe Glu Thr Ala Leu Leu Ser Ser Gly Phe Ser Leu Glu Asp
            660                 665                 670         
Pro Gln Thr His Ser Asn Arg Ile Tyr Arg Met Ile Lys Leu Gly Leu
        675                 680                 685             
Gly Ile Asp Glu Asp Glu Val Ala Ala Glu Glu Pro Asn Ala Ala Val
    690                 695                 700                 
Pro Asp Glu Ile Pro Leu Ser Arg Ala Met Arg Met Arg Leu Ala Trp
705                 710                 715                 720 
Lys Lys Ser Ile Arg Leu Gly Val His Ser Trp Lys Thr Cys Ala Leu
                725                 730                 735     
Val
    


<210> 1162
<211> 952
<212> PRT
<213> Homo sapiens

<400> 1162
Glu Asn Lys Ser Lys Trp Thr Cys Thr Gln Ser Ser Ile Ser Pro Gln
 1               5                  10                  15      
Tyr Asn Ile Cys Glu Gln Met Val Gln Ile Arg Asp Asp His Ile Arg
            20                  25                  30          
Phe Ile Ser Glu Leu Ala Arg Tyr Ser Asn Ser Glu Val Val Thr Gly
        35                  40                  45              
Ser Gly Leu Asp Ser Gln Lys Ser Asp Glu Glu Tyr Arg Glu Leu Phe
    50                  55                  60                  
Asp Leu Ala Leu Arg Gly Leu Gln Leu Leu Ser Lys Trp Ser Ala His
65                  70                  75                  80  
Val Met Glu Val Tyr Ser Trp Lys Leu Val His Pro Thr Asp Lys Phe
                85                  90                  95      
Cys Asn Lys Asp Cys Pro Gly Thr Ala Glu Glu Tyr Glu Arg Ala Thr
            100                 105                 110         
Arg Tyr Asn Tyr Thr Ser Glu Glu Lys Phe Ala Phe Val Glu Val Ile
        115                 120                 125             
Ala Met Ile Lys Gly Leu Gln Val Leu Met Gly Arg Met Glu Ser Val
    130                 135                 140                 
Phe Asn Gln Ala Ile Arg Asn Thr Ile Tyr Ala Ala Leu Gln Asp Phe
145                 150                 155                 160 
Ala Gln Val Thr Leu Arg Glu Pro Leu Arg Gln Ala Val Arg Lys Lys
                165                 170                 175     
Lys Asn Val Leu Ile Ser Val Leu Gln Ala Ile Arg Lys Thr Ile Cys
            180                 185                 190         
Asp Trp Glu Gly Gly Arg Glu Pro Pro Asn Asp Pro Cys Leu Arg Gly
        195                 200                 205             
Glu Lys Asp Pro Lys Gly Gly Phe Asp Ile Lys Val Pro Arg Arg Ala
    210                 215                 220                 
Val Gly Pro Ser Ser Thr Gln Ala Cys Gln Trp Ser Pro Arg Ala Leu
225                 230                 235                 240 
Phe His Pro Thr Gly Gly Thr Gln Gly Arg Arg Gly Cys Arg Ser Leu
                245                 250                 255     
Leu Tyr Met Val Arg Thr Met Leu Glu Ser Leu Ile Ala Asp Lys Ser
            260                 265                 270         
Gly Ser Lys Lys Thr Leu Arg Ser Ser Leu Asp Gly Pro Ile Val Leu
        275                 280                 285             
Ala Ile Glu Asp Phe His Lys Gln Ser Phe Phe Phe Thr His Leu Leu
    290                 295                 300                 
Asn Ile Ser Glu Ala Leu Gln Gln Cys Cys Asp Leu Ser Gln Leu Trp
305                 310                 315                 320 
Phe Arg Glu Phe Phe Leu Glu Leu Thr Met Gly Arg Arg Ile Gln Phe
                325                 330                 335     
Pro Ile Glu Met Ser Met Pro Trp Ile Leu Thr Asp His Ile Leu Glu
            340                 345                 350         
Thr Lys Glu Pro Ser Met Met Glu Tyr Val Leu Tyr Pro Leu Asp Leu
        355                 360                 365             
Tyr Asn Asp Ser Ala Tyr Tyr Ala Leu Thr Lys Phe Lys Lys Gln Phe
    370                 375                 380                 
Leu Tyr Asp Glu Ile Glu Ala Glu Val Asn Leu Cys Phe Asp Gln Phe
385                 390                 395                 400 
Val Tyr Lys Leu Ala Asp Gln Ile Phe Ala Tyr Tyr Lys Ala Met Ala
                405                 410                 415     
Gly Ser Val Leu Leu Asp Lys Arg Phe Arg Ala Glu Cys Lys Asn Tyr
            420                 425                 430         
Gly Val Ile Ile Pro Tyr Pro Pro Ser Asn Arg Tyr Glu Thr Leu Leu
        435                 440                 445             
Lys Gln Arg His Val Gln Leu Leu Gly Arg Ser Ile Asp Leu Asn Arg
    450                 455                 460                 
Leu Ile Thr Gln Arg Ile Ser Ala Ala Met Tyr Lys Ser Leu Asp Gln
465                 470                 475                 480 
Ala Ile Ser Arg Phe Glu Ser Glu Asp Leu Thr Ser Ile Val Glu Leu
                485                 490                 495     
Glu Trp Leu Leu Glu Ile Asn Arg Leu Thr His Arg Leu Leu Cys Lys
            500                 505                 510         
His Met Thr Leu Asp Ser Phe Asp Ala Met Phe Arg Glu Ala Asn His
        515                 520                 525             
Asn Val Ser Ala Pro Tyr Gly Arg Ile Thr Leu His Val Phe Trp Glu
    530                 535                 540                 
Leu Asn Phe Asp Phe Leu Pro Asn Tyr Cys Tyr Asn Gly Ser Thr Asn
545                 550                 555                 560 
Arg Phe Val Arg Thr Ala Ile Pro Phe Thr Gln Glu Pro Gln Arg Asp
                565                 570                 575     
Lys Pro Ala Asn Val Gln Pro Tyr Tyr Leu Tyr Gly Ser Lys Pro Leu
            580                 585                 590         
Asn Ile Ala Tyr Ser His Ile Tyr Ser Ser Tyr Arg Asn Phe Val Gly
        595                 600                 605             
Pro Pro His Phe Lys Thr Ile Cys Arg Leu Leu Gly Tyr Gln Gly Ile
    610                 615                 620                 
Ala Val Val Met Glu Glu Leu Leu Lys Ile Val Lys Ser Leu Leu Gln
625                 630                 635                 640 
Gly Thr Ile Leu Gln Tyr Val Lys Thr Leu Ile Glu Val Met Pro Lys
                645                 650                 655     
Ile Cys Arg Leu Pro Arg His Glu Tyr Gly Ser Pro Gly Ile Leu Glu
            660                 665                 670         
Phe Phe His His Gln Leu Lys Asp Ile Ile Glu Tyr Ala Glu Leu Lys
        675                 680                 685             
Thr Asp Val Phe Gln Ser Leu Arg Glu Val Gly Asn Ala Ile Leu Phe
    690                 695                 700                 
Cys Leu Leu Ile Glu Gln Ala Leu Ser Gln Glu Glu Val Cys Asp Leu
705                 710                 715                 720 
Leu His Ala Ala Pro Phe Gln Asn Ile Leu Pro Arg Val Tyr Ile Lys
                725                 730                 735     
Glu Gly Glu Arg Leu Glu Val Arg Met Lys Arg Leu Glu Ala Lys Tyr
            740                 745                 750         
Ala Pro Leu His Leu Val Pro Leu Ile Glu Arg Leu Gly Thr Pro Gln
        755                 760                 765             
Gln Ile Ala Ile Ala Arg Glu Gly Asp Leu Leu Thr Lys Glu Arg Leu
    770                 775                 780                 
Cys Cys Gly Leu Ser Met Phe Glu Val Ile Leu Thr Arg Ile Arg Ser
785                 790                 795                 800 
Tyr Leu Gln Asp Pro Ile Trp Arg Gly Pro Pro Pro Thr Asn Gly Val
                805                 810                 815     
Met His Val Asp Glu Cys Val Glu Phe His Arg Leu Trp Ser Ala Met
            820                 825                 830         
Gln Phe Val Tyr Cys Ile Pro Val Gly Thr Asn Glu Phe Thr Ala Glu
        835                 840                 845             
Gln Cys Phe Gly Asp Gly Leu Asn Trp Ala Gly Cys Ser Ile Ile Val
    850                 855                 860                 
Leu Leu Gly Gln Gln Arg Arg Phe Asp Leu Phe Asp Phe Cys Tyr His
865                 870                 875                 880 
Leu Leu Lys Val Gln Arg Gln Asp Gly Lys Asp Glu Ile Ile Lys Asn
                885                 890                 895     
Val Pro Leu Lys Lys Met Ala Asp Arg Ile Arg Lys Tyr Gln Ile Leu
            900                 905                 910         
Asn Asn Glu Val Phe Ala Ile Leu Asn Lys Tyr Met Lys Ser Val Glu
        915                 920                 925             
Thr Asp Ser Ser Thr Val Glu His Val Arg Cys Phe Gln Pro Pro Ile
    930                 935                 940                 
His Gln Ser Leu Ala Thr Thr Cys
945                 950         


<210> 1163
<211> 184
<212> PRT
<213> Homo sapiens

<400> 1163
Met Val Ser Lys Leu Leu Leu Thr Ile Gln Leu Cys Pro Lys Thr Glu
 1               5                  10                  15      
Phe Gln Pro Ser Glu Lys Phe Gly Glu Asp Leu Ser Asp Asn Thr Trp
            20                  25                  30          
Glu Tyr Ile Phe Ala Ile Asp Leu Leu Cys Cys His Gln Lys Trp Ile
        35                  40                  45              
Trp Thr His Asp Asn Ile Ile Ser Lys Glu Leu Trp Pro Val Met Asp
    50                  55                  60                  
Lys Trp Ile Lys Tyr Arg Lys Gly His Ala Asn Ile Ala Tyr Thr Pro
65                  70                  75                  80  
Asp Ile Ile Ile Ala Ser Ile Leu Arg Leu Ile Gly Arg Leu Gly Gln
                85                  90                  95      
Leu Gly Leu Lys Glu Gly Phe Pro Ser Ala Val Lys Asn Ile Ser Ser
            100                 105                 110         
Val Ile Gly Met Phe Ile Gln His Ala His Asp Glu Asp Ile Pro Trp
        115                 120                 125             
Gly Ile Gln Leu Ala Ala Val Tyr Ala Leu Cys Asp Leu Ser Pro Ser
    130                 135                 140                 
Asn Pro Ala Glu Ile Ser Lys Ile Leu Glu Ala Trp Arg Arg Glu Ala
145                 150                 155                 160 
Ser Lys Ser Val Pro Ser Ala Ile Val Ser Cys Leu Glu Glu Val Ser
                165                 170                 175     
Ala Leu Ser Thr Glu Glu Leu Gly
            180                 


<210> 1164
<211> 348
<212> PRT
<213> Homo sapiens

<400> 1164
Met Ile Pro Leu Leu Leu Ala Ala Leu Leu Cys Val Pro Ala Gly Ala
 1               5                  10                  15      
Leu Thr Cys Tyr Gly Asp Ser Gly Gln Pro Val Asp Trp Phe Val Val
            20                  25                  30          
Tyr Lys Leu Pro Ala Leu Arg Gly Ser Gly Glu Ala Ala Gln Arg Gly
        35                  40                  45              
Leu Gln Tyr Lys Tyr Leu Asp Glu Ser Ser Gly Gly Trp Arg Asp Gly
    50                  55                  60                  
Arg Ala Leu Ile Asn Ser Pro Glu Gly Ala Val Gly Arg Ser Leu Gln
65                  70                  75                  80  
Pro Leu Tyr Arg Ser Asn Thr Ser Gln Leu Ala Phe Leu Leu Tyr Asn
                85                  90                  95      
Asp Gln Pro Pro Gln Pro Ser Lys Ala Gln Asp Ser Ser Met Arg Gly
            100                 105                 110         
His Thr Lys Gly Val Leu Leu Leu Asp His Asp Gly Gly Phe Trp Leu
        115                 120                 125             
Val His Ser Val Pro Asn Phe Pro Pro Pro Ala Ser Ser Ala Ala Tyr
    130                 135                 140                 
Ser Trp Pro His Ser Ala Cys Thr Tyr Gly Gln Thr Leu Leu Cys Lys
145                 150                 155                 160 
Gln Leu Thr Tyr Thr Tyr Pro Trp Val Tyr Asn Tyr Gln Leu Glu Gly
                165                 170                 175     
Ile Phe Ala Gln Glu Phe Pro Asp Leu Glu Asn Val Val Lys Gly His
            180                 185                 190         
His Val Ser Gln Glu Pro Trp Asn Ser Ser Ile Thr Leu Thr Ser Gln
        195                 200                 205             
Ala Gly Ala Val Phe Gln Ser Phe Ala Lys Phe Ser Lys Phe Gly Asp
    210                 215                 220                 
Asp Leu Tyr Ser Gly Trp Leu Ala Ala Ala Leu Gly Thr Asn Leu Gln
225                 230                 235                 240 
Val Gln Phe Trp His Lys Thr Val Gly Ile Leu Pro Ser Asn Cys Ser
                245                 250                 255     
Asp Ile Trp Gln Val Leu Asn Val Asn Gln Ile Ala Phe Pro Gly Pro
            260                 265                 270         
Ala Gly Pro Ser Phe Asn Ser Thr Glu Asp His Ser Lys Trp Cys Val
        275                 280                 285             
Ser Pro Lys Gly Pro Trp Thr Cys Val Gly Asp Met Asn Arg Asn Gln
    290                 295                 300                 
Gly Glu Glu Gln Arg Gly Gly Gly Thr Leu Cys Ala Gln Leu Pro Ala
305                 310                 315                 320 
Leu Trp Lys Ala Phe Gln Pro Leu Val Lys Asn Tyr Gln Pro Cys Asn
                325                 330                 335     
Gly Met Ala Arg Lys Pro Ser Arg Ala Tyr Lys Ile
            340                 345             


<210> 1165
<211> 919
<212> PRT
<213> Homo sapiens

<400> 1165
Met Ala Ala Asp Val Phe Met Cys Ser Pro Arg Arg Pro Arg Ser Arg
 1               5                  10                  15      
Gly Arg Gln Val Leu Leu Lys Pro Gln Val Ser Glu Asp Asp Asp Asp
            20                  25                  30          
Ser Asp Thr Asp Glu Pro Ser Pro Pro Pro Ala Ser Gly Ala Ala Thr
        35                  40                  45              
Pro Ala Arg Ala His Ala Ser Ala Ala Pro Pro Pro Pro Arg Ala Gly
    50                  55                  60                  
Pro Gly Arg Glu Glu Pro Pro Arg Arg Gln Gln Ile Ile His Ser Gly
65                  70                  75                  80  
His Phe Met Val Ser Ser Pro His Arg Glu His Pro Pro Lys Lys Gly
                85                  90                  95      
Tyr Asp Phe Asp Thr Val Asn Lys Gln Thr Cys Gln Thr Tyr Ser Phe
            100                 105                 110         
Gly Lys Thr Ser Ser Cys His Leu Ser Ile Asp Ala Ser Leu Thr Lys
        115                 120                 125             
Leu Phe Glu Cys Met Thr Leu Ala Tyr Ser Gly Lys Leu Val Ser Pro
    130                 135                 140                 
Lys Trp Lys Asn Phe Lys Gly Leu Lys Leu Gln Trp Arg Asp Lys Ile
145                 150                 155                 160 
Arg Leu Asn Asn Ala Ile Trp Arg Ala Trp Tyr Met Gln Tyr Leu Glu
                165                 170                 175     
Lys Arg Lys Asn Pro Val Cys His Phe Val Thr Pro Leu Asp Gly Ser
            180                 185                 190         
Val Asp Val Asp Glu His Arg Arg Pro Glu Ala Ile Thr Thr Glu Gly
        195                 200                 205             
Lys Tyr Trp Lys Ser Arg Ile Glu Ile Val Ile Arg Glu Tyr His Lys
    210                 215                 220                 
Trp Arg Thr Tyr Phe Lys Lys Arg Leu Gln Gln His Lys Asp Glu Asp
225                 230                 235                 240 
Leu Ser Ser Leu Val Gln Asp Asp Asp Met Leu Tyr Trp His Lys His
                245                 250                 255     
Gly Asp Gly Trp Lys Thr Pro Val Pro Met Glu Glu Asp Pro Leu Leu
            260                 265                 270         
Asp Thr Asp Met Leu Met Ser Glu Phe Ser Asp Thr Leu Phe Ser Thr
        275                 280                 285             
Leu Ser Ser His Gln Pro Val Ala Trp Pro Asn Pro Arg Glu Ile Ala
    290                 295                 300                 
His Leu Gly Asn Ala Asp Met Ile Gln Pro Gly Leu Ile Pro Leu Gln
305                 310                 315                 320 
Pro Asn Leu Asp Phe Met Asp Thr Phe Glu Pro Phe Gln Asp Leu Phe
                325                 330                 335     
Ser Ser Ser Arg Ser Ile Phe Gly Ser Met Leu Pro Ala Ser Ala Ser
            340                 345                 350         
Ala Pro Val Pro Asp Pro Asn Asn Pro Pro Ala Gln Glu Ser Ile Leu
        355                 360                 365             
Pro Thr Thr Ala Leu Pro Thr Val Ser Leu Pro Asp Ser Leu Ile Ala
    370                 375                 380                 
Pro Pro Thr Ala Pro Ser Leu Ala His Met Asp Gly Gln Gly Cys Glu
385                 390                 395                 400 
His Thr Ser Arg Thr Glu Asp Pro Phe Ile Gln Pro Thr Asp Phe Gly
                405                 410                 415     
Pro Ser Glu Pro Pro Leu Ser Val Pro Gln Pro Phe Leu Pro Val Phe
            420                 425                 430         
Thr Met Pro Leu Leu Ser Pro Ser Pro Ala Pro Pro Pro Ile Ser Pro
        435                 440                 445             
Val Leu Pro Leu Val Pro Pro Pro Ala Thr Ala Leu Asn Pro Pro Ala
    450                 455                 460                 
Pro Pro Thr Phe His Gln Pro Gln Lys Phe Ala Gly Val Asn Lys Ala
465                 470                 475                 480 
Pro Ser Val Ile Thr His Thr Ala Ser Ala Thr Leu Thr His Asp Ala
                485                 490                 495     
Pro Ala Thr Thr Phe Ser Gln Ser Gln Gly Leu Val Ile Thr Thr His
            500                 505                 510         
His Pro Ala Pro Ser Ala Ala Pro Cys Gly Leu Ala Leu Ser Pro Val
        515                 520                 525             
Thr Arg Pro Pro Gln Pro Arg Leu Thr Phe Val His Pro Lys Pro Val
    530                 535                 540                 
Ser Leu Thr Gly Gly Arg Pro Lys Gln Pro His Lys Ile Val Pro Ala
545                 550                 555                 560 
Pro Lys Pro Glu Pro Val Ser Leu Val Leu Lys Asn Ala Arg Ile Ala
                565                 570                 575     
Pro Ala Ala Phe Ser Gly Gln Pro Gln Ala Val Ile Met Thr Ser Gly
            580                 585                 590         
Pro Leu Lys Arg Glu Gly Met Leu Ala Ser Thr Val Ser Gln Ser Asn
        595                 600                 605             
Val Val Ile Ala Pro Ala Ala Ile Ala Arg Ala Pro Gly Val Pro Glu
    610                 615                 620                 
Phe His Ser Ser Ile Leu Val Thr Asp Leu Gly His Gly Thr Ser Ser
625                 630                 635                 640 
Pro Pro Ala Pro Val Ser Arg Leu Phe Pro Ser Thr Ala Gln Asp Pro
                645                 650                 655     
Leu Gly Lys Gly Glu Gln Val Pro Leu His Gly Gly Ser Pro Gln Val
            660                 665                 670         
Thr Val Thr Gly Pro Ser Arg Asp Cys Pro Asn Ser Gly Gln Ala Ser
        675                 680                 685             
Pro Cys Ala Ser Glu Gln Ser Pro Ser Pro Gln Ser Pro Gln Asn Asn
    690                 695                 700                 
Cys Ser Gly Lys Ser Asp Pro Lys Asn Val Ala Ala Leu Lys Asn Arg
705                 710                 715                 720 
Gln Met Lys His Ile Ser Ala Glu Gln Lys Arg Arg Phe Asn Ile Lys
                725                 730                 735     
Met Cys Phe Asp Met Leu Asn Ser Leu Ile Ser Asn Asn Ser Lys Leu
            740                 745                 750         
Thr Ser His Ala Ile Thr Leu Gln Lys Thr Val Glu Tyr Ile Thr Lys
        755                 760                 765             
Leu Gln Gln Glu Arg Gly Gln Met Gln Glu Glu Ala Arg Arg Leu Arg
    770                 775                 780                 
Glu Glu Ile Glu Glu Leu Asn Ala Thr Ile Ile Ser Cys Gln Gln Leu
785                 790                 795                 800 
Leu Pro Ala Thr Gly Val Pro Val Thr Arg Arg Gln Phe Asp His Met
                805                 810                 815     
Lys Asp Met Phe Asp Glu Tyr Val Lys Thr Arg Thr Leu Gln Asn Trp
            820                 825                 830         
Lys Phe Trp Ile Phe Ser Ile Ile Ile Lys Pro Leu Phe Glu Ser Phe
        835                 840                 845             
Lys Gly Met Val Ser Thr Ser Ser Leu Glu Glu Leu His Arg Thr Ala
    850                 855                 860                 
Leu Ser Trp Leu Asp Gln His Cys Ser Leu Pro Ile Leu Arg Pro Met
865                 870                 875                 880 
Val Leu Ser Thr Leu Arg Gln Leu Ser Thr Ser Thr Ser Ile Leu Thr
                885                 890                 895     
Asp Pro Ala Gln Leu Pro Glu Gln Ala Ser Lys Ala Val Thr Arg Ile
            900                 905                 910         
Gly Lys Arg Leu Gly Glu Ser
        915                 


<210> 1166
<211> 315
<212> PRT
<213> Homo sapiens

<400> 1166
Met Glu Pro Glu Ala Gly Thr Asn Arg Thr Ala Val Ala Glu Phe Ile
 1               5                  10                  15      
Leu Leu Gly Leu Val Gln Thr Glu Glu Met Gln Pro Val Val Phe Val
            20                  25                  30          
Leu Leu Leu Phe Ala Tyr Leu Val Thr Thr Gly Gly Asn Leu Ser Ile
        35                  40                  45              
Leu Ala Ala Val Leu Val Glu Pro Lys Leu His Ala Pro Met Tyr Phe
    50                  55                  60                  
Phe Leu Gly Asn Leu Ser Val Leu Asp Val Gly Cys Ile Thr Val Thr
65                  70                  75                  80  
Val Pro Ala Met Leu Gly Arg Leu Leu Ser His Lys Ser Thr Ile Ser
                85                  90                  95      
Tyr Asp Ala Cys Leu Ser Gln Leu Phe Phe Phe His Leu Leu Ala Gly
            100                 105                 110         
Met Asp Cys Phe Leu Leu Thr Ala Met Ala Tyr Asp Arg Leu Leu Ala
        115                 120                 125             
Ile Cys Gln Pro Leu Thr Tyr Ser Thr Arg Met Ser Gln Thr Val Gln
    130                 135                 140                 
Arg Met Leu Val Ala Ala Ser Leu Ala Cys Ala Phe Thr Asn Ala Leu
145                 150                 155                 160 
Thr His Thr Val Ala Met Ser Thr Leu Asn Phe Cys Gly Pro Asn Glu
                165                 170                 175     
Val Asn His Phe Tyr Cys Asp Leu Pro Gln Leu Phe Gln Leu Ser Cys
            180                 185                 190         
Ser Ser Thr Gln Leu Asn Glu Leu Leu Leu Phe Ala Val Gly Phe Ile
        195                 200                 205             
Met Ala Gly Thr Pro Leu Val Leu Ile Ile Thr Ala Tyr Ser His Val
    210                 215                 220                 
Ala Ala Ala Val Leu Arg Ile Arg Ser Val Glu Gly Arg Lys Lys Ala
225                 230                 235                 240 
Phe Ser Thr Cys Gly Ser His Leu Thr Val Val Cys Leu Phe Phe Gly
                245                 250                 255     
Arg Gly Ile Phe Asn Tyr Met Arg Leu Gly Ser Glu Glu Ala Ser Asp
            260                 265                 270         
Lys Asp Lys Gly Val Gly Val Phe Asn Thr Val Ile Asn Pro Met Leu
        275                 280                 285             
Asn Pro Leu Ile Tyr Ser Leu Arg Asn Pro Asp Val Gln Gly Ala Leu
    290                 295                 300                 
Trp Gln Ile Phe Leu Gly Arg Arg Ser Leu Thr
305                 310                 315 


<210> 1167
<211> 1523
<212> PRT
<213> Homo sapiens

<400> 1167
Met Ala Pro Gly Trp Ala Gly Val Gly Ala Ala Val Arg Ala Arg Leu
 1               5                  10                  15      
Ala Leu Ala Leu Ala Leu Ala Ser Val Leu Ser Gly Pro Pro Ala Val
            20                  25                  30          
Ala Cys Pro Thr Lys Cys Thr Cys Ser Ala Ala Ser Val Asp Cys His
        35                  40                  45              
Gly Leu Gly Leu Arg Ala Val Pro Arg Gly Ile Pro Arg Asn Ala Glu
    50                  55                  60                  
Arg Leu Asp Leu Asp Arg Asn Asn Ile Thr Arg Ile Thr Lys Met Asp
65                  70                  75                  80  
Phe Ala Gly Leu Lys Asn Leu Arg Val Leu His Leu Glu Asp Asn Gln
                85                  90                  95      
Val Ser Val Ile Glu Arg Gly Ala Phe Gln Asp Leu Lys Gln Leu Glu
            100                 105                 110         
Arg Leu Arg Leu Asn Lys Asn Lys Leu Gln Val Leu Pro Glu Leu Leu
        115                 120                 125             
Phe Gln Ser Thr Pro Lys Leu Thr Arg Leu Asp Leu Ser Glu Asn Gln
    130                 135                 140                 
Ile Gln Gly Ile Pro Arg Lys Ala Phe Arg Gly Ile Thr Asp Val Lys
145                 150                 155                 160 
Asn Leu Gln Leu Asp Asn Asn His Ile Ser Cys Ile Glu Asp Gly Ala
                165                 170                 175     
Phe Arg Ala Leu Arg Asp Leu Glu Ile Leu Thr Leu Asn Asn Asn Asn
            180                 185                 190         
Ile Ser Arg Ile Leu Val Thr Ser Phe Asn His Met Pro Lys Ile Arg
        195                 200                 205             
Thr Leu Arg Leu His Ser Asn His Leu Tyr Cys Asp Cys His Leu Ala
    210                 215                 220                 
Trp Leu Ser Asp Trp Leu Arg Gln Arg Arg Thr Val Gly Gln Phe Thr
225                 230                 235                 240 
Leu Cys Met Ala Pro Val His Leu Arg Gly Phe Asn Val Ala Asp Val
                245                 250                 255     
Gln Lys Lys Glu Tyr Val Cys Pro Ala Pro His Ser Glu Pro Pro Ser
            260                 265                 270         
Cys Asn Ala Asn Ser Ile Ser Cys Pro Ser Pro Cys Thr Cys Ser Asn
        275                 280                 285             
Asn Ile Val Asp Cys Arg Gly Lys Gly Leu Met Glu Ile Pro Ala Asn
    290                 295                 300                 
Leu Pro Glu Gly Ile Val Glu Ile Arg Leu Glu Gln Asn Ser Ile Lys
305                 310                 315                 320 
Ala Ile Pro Ala Gly Ala Phe Thr Gln Tyr Lys Lys Leu Lys Arg Ile
                325                 330                 335     
Asp Ile Ser Lys Asn Gln Ile Ser Asp Ile Ala Pro Asp Ala Phe Gln
            340                 345                 350         
Gly Leu Lys Ser Leu Thr Ser Leu Val Leu Tyr Gly Asn Lys Ile Thr
        355                 360                 365             
Glu Ile Ala Lys Gly Leu Phe Asp Gly Leu Val Ser Leu Gln Leu Leu
    370                 375                 380                 
Leu Leu Asn Ala Asn Lys Ile Asn Cys Leu Arg Val Asn Thr Phe Gln
385                 390                 395                 400 
Asp Leu Gln Asn Leu Asn Leu Leu Ser Leu Tyr Asp Asn Lys Leu Gln
                405                 410                 415     
Thr Ile Ser Lys Gly Leu Phe Ala Pro Leu Gln Ser Ile Gln Thr Leu
            420                 425                 430         
His Leu Ala Gln Asn Pro Phe Val Cys Asp Cys His Leu Lys Trp Leu
        435                 440                 445             
Ala Asp Tyr Leu Gln Asp Asn Pro Ile Glu Thr Ser Gly Ala Arg Cys
    450                 455                 460                 
Ser Ser Pro Arg Arg Leu Ala Asn Lys Arg Ile Ser Gln Ile Lys Ser
465                 470                 475                 480 
Lys Lys Phe Arg Cys Ser Gly Ser Glu Asp Tyr Arg Ser Arg Phe Ser
                485                 490                 495     
Ser Glu Cys Phe Met Asp Leu Val Cys Pro Glu Lys Cys Arg Cys Glu
            500                 505                 510         
Gly Thr Ile Val Asp Cys Ser Asn Gln Lys Leu Val Arg Ile Pro Ser
        515                 520                 525             
His Leu Pro Glu Tyr Val Thr Asp Leu Arg Leu Asn Asp Asn Glu Val
    530                 535                 540                 
Ser Val Leu Glu Ala Thr Gly Ile Phe Lys Lys Leu Pro Asn Leu Arg
545                 550                 555                 560 
Lys Ile Asn Leu Ser Asn Asn Lys Ile Lys Glu Val Arg Glu Gly Ala
                565                 570                 575     
Phe Asp Gly Ala Ala Ser Val Gln Glu Leu Met Leu Thr Gly Asn Gln
            580                 585                 590         
Leu Glu Thr Val His Gly Arg Val Phe Arg Gly Leu Ser Gly Leu Lys
        595                 600                 605             
Thr Leu Met Leu Arg Ser Asn Leu Ile Gly Cys Val Ser Asn Asp Thr
    610                 615                 620                 
Phe Ala Gly Leu Ser Ser Val Arg Leu Leu Ser Leu Tyr Asp Asn Arg
625                 630                 635                 640 
Ile Thr Thr Ile Thr Pro Gly Ala Phe Thr Thr Leu Val Ser Leu Ser
                645                 650                 655     
Thr Ile Asn Leu Leu Ser Asn Pro Phe Asn Cys Asn Cys His Leu Ala
            660                 665                 670         
Trp Leu Gly Lys Trp Leu Arg Lys Arg Arg Ile Val Ser Gly Asn Pro
        675                 680                 685             
Arg Cys Gln Lys Pro Phe Phe Leu Lys Glu Ile Pro Ile Gln Asp Val
    690                 695                 700                 
Ala Ile Gln Asp Phe Thr Cys Asp Gly Asn Glu Glu Ser Ser Cys Gln
705                 710                 715                 720 
Leu Ser Pro Arg Cys Pro Glu Gln Cys Thr Cys Met Glu Thr Val Val
                725                 730                 735     
Arg Cys Ser Asn Lys Gly Leu Arg Ala Leu Pro Arg Gly Met Pro Lys
            740                 745                 750         
Asp Val Thr Glu Leu Tyr Leu Glu Gly Asn His Leu Thr Ala Val Pro
        755                 760                 765             
Arg Glu Leu Ser Ala Leu Arg His Leu Thr Leu Ile Asp Leu Ser Asn
    770                 775                 780                 
Asn Ser Ile Ser Met Leu Thr Asn Tyr Thr Phe Ser Asn Met Ser His
785                 790                 795                 800 
Leu Ser Thr Leu Ile Leu Ser Tyr Asn Arg Leu Arg Cys Ile Pro Val
                805                 810                 815     
His Ala Phe Asn Gly Leu Arg Ser Leu Arg Val Leu Thr Leu His Gly
            820                 825                 830         
Asn Asp Ile Ser Ser Val Pro Glu Gly Ser Phe Asn Asp Leu Thr Ser
        835                 840                 845             
Leu Ser His Leu Ala Leu Gly Thr Asn Pro Leu His Cys Asp Cys Ser
    850                 855                 860                 
Leu Arg Trp Leu Ser Glu Trp Val Lys Ala Gly Tyr Lys Glu Pro Gly
865                 870                 875                 880 
Ile Ala Arg Cys Ser Ser Pro Glu Pro Met Ala Asp Arg Leu Leu Leu
                885                 890                 895     
Thr Thr Pro Thr His Arg Phe Gln Cys Lys Gly Pro Val Asp Ile Asn
            900                 905                 910         
Ile Val Ala Lys Cys Asn Ala Cys Leu Ser Ser Pro Cys Lys Asn Asn
        915                 920                 925             
Gly Thr Cys Thr Gln Asp Pro Val Glu Leu Tyr Arg Cys Ala Cys Pro
    930                 935                 940                 
Tyr Ser Tyr Lys Gly Lys Asp Cys Thr Val Pro Ile Asn Thr Cys Ile
945                 950                 955                 960 
Gln Asn Pro Cys Gln His Gly Gly Thr Cys His Leu Ser Asp Ser His
                965                 970                 975     
Lys Asp Gly Phe Ser Cys Ser Cys Pro Leu Gly Phe Glu Gly Gln Arg
            980                 985                 990         
Cys Glu Ile Asn Pro Asp Asp Cys Glu Asp Asn Asp Cys Glu Asn Asn
        995                 1000                1005            
Ala Thr Cys Val Asp Gly Ile Asn Asn Tyr Val Cys Ile Cys Pro Pro
    1010                1015                1020                
Asn Tyr Thr Gly Glu Leu Cys Asp Glu Val Ile Asp His Cys Val Pro
1025                1030                1035                1040
Glu Leu Asn Leu Cys Gln His Glu Ala Lys Cys Ile Pro Leu Asp Lys
                1045                1050                1055    
Gly Phe Ser Cys Glu Cys Val Pro Gly Tyr Ser Gly Lys Leu Cys Glu
            1060                1065                1070        
Thr Asp Asn Asp Asp Cys Val Ala His Lys Cys Arg His Gly Ala Gln
        1075                1080                1085            
Cys Val Asp Thr Ile Asn Gly Tyr Thr Cys Thr Cys Pro Gln Gly Phe
    1090                1095                1100                
Ser Gly Pro Phe Cys Glu His Pro Pro Pro Met Val Leu Leu Gln Thr
1105                1110                1115                1120
Ser Pro Cys Asp Gln Tyr Glu Cys Gln Asn Gly Ala Gln Cys Ile Val
                1125                1130                1135    
Val Gln Gln Glu Pro Thr Cys Arg Cys Pro Pro Gly Phe Ala Gly Pro
            1140                1145                1150        
Arg Cys Glu Lys Leu Ile Thr Val Asn Phe Val Gly Lys Asp Ser Tyr
        1155                1160                1165            
Val Glu Leu Ala Ser Ala Lys Val Arg Pro Gln Ala Asn Ile Ser Leu
    1170                1175                1180                
Gln Val Ala Thr Asp Lys Asp Asn Gly Ile Leu Leu Tyr Lys Gly Asp
1185                1190                1195                1200
Asn Asp Pro Leu Ala Leu Glu Leu Tyr Gln Gly His Val Arg Leu Val
                1205                1210                1215    
Tyr Asp Ser Leu Ser Ser Pro Pro Thr Thr Val Tyr Ser Val Glu Thr
            1220                1225                1230        
Val Asn Asp Gly Gln Phe His Ser Val Glu Leu Val Thr Leu Asn Gln
        1235                1240                1245            
Thr Leu Asn Leu Val Val Asp Lys Gly Thr Pro Lys Ser Leu Gly Lys
    1250                1255                1260                
Leu Gln Lys Gln Pro Ala Val Gly Ile Asn Ser Pro Leu Tyr Leu Gly
1265                1270                1275                1280
Gly Ile Pro Thr Ser Thr Gly Leu Ser Ala Leu Arg Gln Gly Thr Asp
                1285                1290                1295    
Arg Pro Leu Gly Gly Phe His Gly Cys Ile His Glu Val Arg Ile Asn
            1300                1305                1310        
Asn Glu Leu Gln Asp Phe Lys Ala Leu Pro Pro Gln Ser Leu Gly Val
        1315                1320                1325            
Ser Pro Gly Cys Lys Ser Cys Thr Val Cys Lys His Gly Leu Cys Arg
    1330                1335                1340                
Ser Val Glu Lys Asp Ser Val Val Cys Glu Cys Arg Pro Gly Trp Thr
1345                1350                1355                1360
Gly Pro Leu Cys Asp Gln Glu Ala Arg Asp Pro Cys Leu Gly His Arg
                1365                1370                1375    
Cys His His Gly Lys Cys Val Ala Thr Gly Thr Ser Tyr Met Cys Lys
            1380                1385                1390        
Cys Ala Glu Gly Tyr Gly Gly Asp Leu Cys Asp Asn Lys Asn Asp Ser
        1395                1400                1405            
Ala Asn Ala Cys Ser Ala Phe Lys Cys His His Gly Gln Cys His Ile
    1410                1415                1420                
Ser Asp Gln Gly Glu Pro Tyr Cys Leu Cys Gln Pro Gly Phe Ser Gly
1425                1430                1435                1440
Glu His Cys Gln Gln Glu Asn Pro Cys Leu Gly Gln Val Val Arg Glu
                1445                1450                1455    
Val Ile Arg Arg Gln Lys Gly Tyr Ala Ser Cys Ala Thr Ala Ser Lys
            1460                1465                1470        
Val Pro Ile Met Glu Cys Arg Gly Gly Cys Gly Pro Gln Cys Cys Gln
        1475                1480                1485            
Pro Thr Arg Ser Lys Arg Arg Lys Tyr Val Phe Gln Cys Thr Asp Gly
    1490                1495                1500                
Ser Ser Phe Val Glu Glu Val Glu Arg His Leu Glu Cys Gly Cys Leu
1505                1510                1515                1520
Ala Cys Ser
            


<210> 1168
<211> 1938
<212> PRT
<213> Homo sapiens

<400> 1168
Met Ser Ser Asp Ala Glu Met Ala Ile Phe Gly Glu Ala Ala Pro Tyr
 1               5                  10                  15      
Leu Arg Lys Pro Glu Lys Glu Arg Ile Glu Ala Gln Asn Arg Pro Phe
            20                  25                  30          
Asp Ser Lys Lys Ala Cys Phe Val Ala Asp Asn Lys Glu Met Tyr Val
        35                  40                  45              
Lys Gly Met Ile Gln Thr Arg Glu Asn Asp Lys Val Ile Val Lys Thr
    50                  55                  60                  
Leu Asp Asp Arg Met Leu Thr Leu Asn Asn Asp Gln Val Phe Pro Met
65                  70                  75                  80  
Asn Pro Pro Lys Phe Asp Lys Ile Glu Asp Met Ala Met Met Thr His
                85                  90                  95      
Leu His Glu Pro Ala Val Leu Tyr Asn Leu Lys Glu Arg Tyr Ala Ala
            100                 105                 110         
Trp Met Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Thr Val Asn Pro
        115                 120                 125             
Tyr Lys Trp Leu Pro Val Tyr Lys Pro Glu Val Val Ala Ala Tyr Arg
    130                 135                 140                 
Gly Lys Lys Arg Gln Glu Ala Pro Pro His Ile Phe Ser Ile Ser Asp
145                 150                 155                 160 
Asn Ala Tyr Gln Phe Met Leu Thr Asp Arg Asp Asn Gln Ser Ile Leu
                165                 170                 175     
Ile Thr Gly Glu Ser Gly Ala Gly Lys Thr Val Asn Thr Lys Arg Val
            180                 185                 190         
Ile Gln Tyr Phe Ala Thr Ile Ala Val Thr Gly Asp Lys Lys Lys Glu
        195                 200                 205             
Thr Gln Pro Gly Lys Met Gln Gly Thr Leu Glu Asp Gln Ile Ile Gln
    210                 215                 220                 
Ala Asn Pro Leu Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Arg Asn
225                 230                 235                 240 
Asp Asn Ser Ser Arg Phe Gly Lys Phe Ile Arg Ile His Phe Gly Ala
                245                 250                 255     
Thr Gly Lys Leu Ala Ser Ala Asp Ile Glu Thr Tyr Leu Leu Glu Lys
            260                 265                 270         
Ser Arg Val Thr Phe Gln Leu Ser Ser Glu Arg Ser Tyr His Ile Phe
        275                 280                 285             
Tyr Gln Ile Met Ser Asn Lys Lys Pro Glu Leu Ile Asp Leu Leu Leu
    290                 295                 300                 
Ile Ser Thr Asn Pro Phe Asp Phe Pro Phe Val Ser Gln Gly Glu Val
305                 310                 315                 320 
Thr Val Ala Ser Ile Asp Asp Ser Glu Glu Leu Leu Ala Thr Asp Asn
                325                 330                 335     
Ala Ile Asp Ile Leu Gly Phe Ser Ser Glu Glu Lys Val Gly Ile Tyr
            340                 345                 350         
Lys Leu Thr Gly Ala Val Met His Tyr Gly Asn Met Lys Phe Lys Gln
        355                 360                 365             
Lys Gln Arg Glu Glu Gln Ala Glu Pro Asp Gly Thr Glu Val Ala Asp
    370                 375                 380                 
Lys Ala Gly Tyr Leu Met Gly Leu Asn Ser Ala Glu Met Leu Lys Gly
385                 390                 395                 400 
Leu Cys Cys Pro Arg Val Lys Val Gly Asn Glu Tyr Val Thr Lys Gly
                405                 410                 415     
Gln Asn Val Gln Gln Val Thr Asn Ser Val Gly Ala Leu Ala Lys Ala
            420                 425                 430         
Val Tyr Glu Lys Met Phe Leu Trp Met Val Thr Arg Ile Asn Gln Gln
        435                 440                 445             
Leu Asp Thr Lys Gln Pro Arg Gln Tyr Phe Ile Gly Val Leu Asp Ile
    450                 455                 460                 
Ala Gly Phe Glu Ile Phe Asp Phe Asn Ser Leu Glu Gln Leu Cys Ile
465                 470                 475                 480 
Asn Phe Thr Asn Glu Lys Leu Gln Gln Phe Phe Asn His His Met Phe
                485                 490                 495     
Val Leu Glu Gln Glu Glu Tyr Lys Lys Glu Gly Ile Glu Trp Glu Phe
            500                 505                 510         
Ile Asp Phe Gly Met Asp Leu Ala Ala Cys Ile Glu Leu Ile Glu Lys
        515                 520                 525             
Pro Met Gly Ile Phe Ser Ile Leu Glu Glu Glu Cys Met Phe Pro Lys
    530                 535                 540                 
Ala Thr Asp Thr Ser Phe Lys Asn Lys Leu Tyr Asp Gln His Leu Gly
545                 550                 555                 560 
Lys Ser Asn Asn Phe Gln Lys Pro Lys Pro Ala Lys Gly Lys Ala Glu
                565                 570                 575     
Ala His Phe Ser Leu Val His Tyr Ala Gly Thr Val Asp Tyr Asn Ile
            580                 585                 590         
Ala Gly Trp Leu Asp Lys Asn Lys Asp Pro Leu Asn Glu Thr Val Val
        595                 600                 605             
Gly Leu Tyr Gln Lys Ser Ser Leu Lys Leu Leu Ser Phe Leu Phe Ser
    610                 615                 620                 
Asn Tyr Ala Gly Ala Glu Thr Gly Asp Ser Gly Gly Ser Lys Lys Gly
625                 630                 635                 640 
Gly Lys Lys Lys Gly Ser Ser Phe Gln Thr Val Ser Ala Val Phe Arg
                645                 650                 655     
Glu Asn Leu Asn Lys Leu Met Thr Asn Leu Arg Ser Thr His Pro His
            660                 665                 670         
Phe Val Arg Cys Leu Ile Pro Asn Glu Thr Lys Thr Pro Gly Val Met
        675                 680                 685             
Asp His Tyr Leu Val Met His Gln Leu Arg Cys Asn Gly Val Leu Glu
    690                 695                 700                 
Gly Ile Arg Ile Cys Arg Lys Gly Phe Pro Ser Arg Ile Leu Tyr Ala
705                 710                 715                 720 
Asp Phe Lys Gln Arg Tyr Arg Ile Leu Asn Ala Ser Ala Ile Pro Glu
                725                 730                 735     
Gly Gln Phe Ile Asp Ser Lys Asn Ala Ser Glu Lys Leu Leu Asn Ser
            740                 745                 750         
Ile Asp Val Asp Arg Glu Gln Phe Arg Phe Gly Asn Thr Lys Val Phe
        755                 760                 765             
Phe Lys Ala Gly Leu Leu Gly Leu Leu Glu Glu Met Arg Asp Glu Lys
    770                 775                 780                 
Leu Val Thr Leu Met Thr Ser Thr Gln Ala Val Cys Arg Gly Tyr Leu
785                 790                 795                 800 
Met Arg Val Glu Phe Lys Lys Met Met Glu Arg Arg Asp Ser Ile Phe
                805                 810                 815     
Cys Ile Gln Tyr Asn Ile Arg Ser Phe Met Asn Val Lys His Trp Pro
            820                 825                 830         
Trp Met Asn Leu Phe Phe Lys Ile Lys Pro Leu Leu Lys Ser Ala Glu
        835                 840                 845             
Ala Glu Lys Glu Met Ala Thr Met Lys Glu Asp Phe Glu Arg Thr Lys
    850                 855                 860                 
Glu Glu Leu Ala Arg Ser Glu Ala Arg Arg Lys Glu Leu Glu Glu Lys
865                 870                 875                 880 
Met Val Ser Leu Leu Gln Glu Lys Asn Asp Leu Gln Leu Gln Val Gln
                885                 890                 895     
Ser Glu Thr Glu Asn Leu Met Asp Ala Glu Glu Arg Cys Glu Gly Leu
            900                 905                 910         
Ile Lys Ser Lys Ile Leu Leu Glu Ala Lys Val Lys Glu Leu Thr Glu
        915                 920                 925             
Arg Leu Glu Glu Glu Glu Glu Met Asn Ser Glu Leu Val Ala Lys Lys
    930                 935                 940                 
Arg Asn Leu Glu Asp Lys Cys Ser Ser Leu Lys Arg Asp Ile Asp Asp
945                 950                 955                 960 
Leu Glu Leu Thr Leu Thr Lys Val Glu Lys Glu Lys His Ala Thr Glu
                965                 970                 975     
Asn Lys Val Lys Asn Leu Ser Glu Glu Met Thr Ala Leu Glu Glu Asn
            980                 985                 990         
Ile Ser Lys Leu Thr Lys Glu Lys Lys Ser Leu Gln Glu Ala His Gln
        995                 1000                1005            
Gln Thr Leu Asp Asp Leu Gln Val Glu Glu Asp Lys Val Asn Gly Leu
    1010                1015                1020                
Ile Lys Ile Asn Ala Lys Leu Glu Gln Gln Thr Asp Asp Leu Glu Gly
1025                1030                1035                1040
Ser Leu Glu Gln Glu Lys Lys Leu Arg Ala Asp Leu Glu Arg Ala Lys
                1045                1050                1055    
Arg Lys Leu Glu Gly Asp Leu Lys Met Ser Gln Glu Ser Ile Met Asp
            1060                1065                1070        
Leu Glu Asn Glu Lys Gln Gln Ile Glu Glu Lys Leu Lys Lys Lys Glu
        1075                1080                1085            
Phe Glu Leu Ser Gln Leu Gln Ala Arg Ile Asp Asp Glu Gln Val His
    1090                1095                1100                
Ser Leu Gln Phe Gln Lys Lys Ile Lys Glu Leu Gln Ala Arg Ile Glu
1105                1110                1115                1120
Glu Leu Glu Glu Glu Ile Glu Ala Glu His Thr Leu Arg Ala Lys Ile
                1125                1130                1135    
Glu Lys Gln Arg Ser Asp Leu Ala Arg Glu Leu Glu Glu Ile Ser Glu
            1140                1145                1150        
Arg Leu Glu Glu Ala Ser Gly Ala Thr Ser Ala Gln Ile Glu Met Asn
        1155                1160                1165            
Lys Lys Arg Glu Ala Glu Phe Gln Lys Met Arg Arg Asp Leu Glu Glu
    1170                1175                1180                
Ala Thr Leu Gln His Glu Ala Thr Ala Ala Thr Leu Arg Lys Lys Gln
1185                1190                1195                1200
Ala Asp Ser Val Ala Glu Leu Gly Glu Gln Ile Asp Asn Leu Gln Arg
                1205                1210                1215    
Val Lys Gln Lys Leu Glu Lys Glu Lys Ser Glu Leu Lys Met Glu Ile
            1220                1225                1230        
Asp Asp Met Ala Ser Asn Ile Glu Ala Leu Ser Lys Ser Lys Ser Asn
        1235                1240                1245            
Ile Glu Arg Thr Cys Arg Thr Val Glu Asp Gln Phe Ser Glu Ile Lys
    1250                1255                1260                
Ala Lys Asp Glu Gln Gln Thr Gln Leu Ile His Asp Leu Asn Met Gln
1265                1270                1275                1280
Lys Ala Arg Leu Gln Thr Gln Asn Gly Glu Leu Ser His Arg Val Glu
                1285                1290                1295    
Glu Lys Glu Ser Leu Ile Ser Gln Leu Thr Lys Ser Lys Gln Ala Leu
            1300                1305                1310        
Thr Gln Gln Leu Glu Glu Leu Lys Arg Gln Met Glu Glu Glu Thr Lys
        1315                1320                1325            
Ala Lys Asn Ala Met Ala His Ala Leu Gln Ser Ser Arg His Asp Cys
    1330                1335                1340                
Asp Leu Leu Arg Glu Gln Tyr Glu Glu Glu Gln Glu Ala Lys Ala Glu
1345                1350                1355                1360
Leu Gln Arg Ala Leu Ser Lys Ala Asn Ser Glu Val Ala Gln Trp Lys
                1365                1370                1375    
Thr Lys Tyr Glu Thr Asp Ala Ile Gln Arg Thr Glu Glu Leu Glu Glu
            1380                1385                1390        
Ala Lys Lys Lys Leu Ala Gln Arg Leu Gln Glu Ala Glu Glu Lys Thr
        1395                1400                1405            
Glu Thr Ala Asn Ser Lys Cys Ala Ser Leu Glu Lys Thr Lys Gln Arg
    1410                1415                1420                
Leu Gln Gly Glu Val Glu Asp Leu Met Arg Asp Leu Glu Arg Ser His
1425                1430                1435                1440
Thr Ala Cys Ala Thr Leu Asp Lys Lys Gln Arg Asn Phe Asp Lys Val
                1445                1450                1455    
Leu Ala Glu Trp Lys Gln Lys Leu Asp Glu Ser Gln Ala Glu Leu Glu
            1460                1465                1470        
Ala Ala Gln Lys Glu Ser Arg Ser Leu Ser Thr Glu Leu Phe Lys Met
        1475                1480                1485            
Arg Asn Ala Tyr Glu Glu Val Val Asp Gln Leu Glu Thr Leu Arg Arg
    1490                1495                1500                
Glu Asn Lys Asn Leu Gln Glu Glu Ile Ser Asp Leu Thr Glu Gln Ile
1505                1510                1515                1520
Ala Glu Thr Gly Lys Asn Leu Gln Glu Ala Glu Lys Thr Lys Lys Leu
                1525                1530                1535    
Val Glu Gln Glu Lys Ser Asp Leu Gln Val Ala Leu Glu Glu Val Glu
            1540                1545                1550        
Gly Ser Leu Glu His Glu Glu Ser Lys Ile Leu Arg Val Gln Leu Glu
        1555                1560                1565            
Leu Ser Gln Val Lys Ser Glu Leu Asp Arg Lys Val Ile Glu Lys Asp
    1570                1575                1580                
Glu Glu Ile Glu Gln Leu Lys Arg Asn Ser Gln Arg Ala Ala Glu Ala
1585                1590                1595                1600
Leu Gln Ser Val Leu Asp Ala Glu Ile Arg Ser Arg Asn Asp Ala Leu
                1605                1610                1615    
Arg Leu Lys Lys Lys Met Glu Gly Asp Leu Asn Glu Met Glu Ile Gln
            1620                1625                1630        
Leu Gly His Ser Asn Arg Gln Met Ala Glu Thr Gln Arg His Leu Arg
        1635                1640                1645            
Thr Val Gln Gly Gln Leu Lys Asp Ser Gln Leu His Leu Asp Asp Ala
    1650                1655                1660                
Leu Arg Ser Asn Glu Asp Leu Lys Glu Gln Leu Ala Ile Val Glu Arg
1665                1670                1675                1680
Arg Asn Gly Leu Leu Leu Glu Glu Leu Glu Glu Met Lys Val Ala Leu
                1685                1690                1695    
Glu Gln Thr Glu Arg Thr Arg Arg Leu Ser Glu Gln Glu Leu Leu Asp
            1700                1705                1710        
Ala Ser Asp Arg Val Gln Leu Leu His Ser Gln Asn Thr Ser Leu Ile
        1715                1720                1725            
Asn Thr Lys Lys Lys Leu Glu Ala Asp Ile Ala Gln Cys Gln Ala Glu
    1730                1735                1740                
Val Glu Asn Ser Ile Gln Glu Ser Arg Asn Ala Glu Glu Lys Ala Lys
1745                1750                1755                1760
Lys Ala Ile Thr Asp Ala Ala Met Met Ala Glu Glu Leu Lys Lys Glu
                1765                1770                1775    
Gln Asp Thr Ser Ala His Leu Glu Arg Met Lys Lys Asn Leu Glu Gln
            1780                1785                1790        
Thr Val Lys Asp Leu Gln His Arg Leu Asp Glu Ala Glu Gln Leu Ala
        1795                1800                1805            
Leu Lys Gly Gly Lys Lys Gln Ile Gln Lys Leu Glu Asn Arg Val Arg
    1810                1815                1820                
Glu Leu Glu Asn Glu Leu Asp Val Glu Gln Lys Arg Gly Ala Glu Ala
1825                1830                1835                1840
Leu Lys Gly Ala His Lys Tyr Glu Arg Lys Val Lys Glu Met Thr Tyr
                1845                1850                1855    
Gln Ala Glu Glu Asp Arg Lys Asn Ile Leu Arg Leu Gln Asp Leu Val
            1860                1865                1870        
Asp Lys Leu Gln Ala Lys Val Lys Ser Tyr Lys Arg Gln Ala Glu Glu
        1875                1880                1885            
Ala Glu Glu Gln Ala Asn Thr Gln Leu Ser Arg Cys Arg Arg Val Gln
    1890                1895                1900                
His Glu Leu Glu Glu Ala Ala Glu Arg Ala Asp Ile Ala Glu Ser Gln
1905                1910                1915                1920
Val Asn Lys Leu Arg Ala Lys Ser Arg Asp Val Gly Ser Gln Lys Met
                1925                1930                1935    
Glu Glu
        


<210> 1169
<211> 333
<212> PRT
<213> Homo sapiens

<400> 1169
Met Val Ser Gly Ser Ser Gly Leu Ala Ala Ala Arg Leu Leu Ser Arg
 1               5                  10                  15      
Ser Phe Leu Leu Pro Gln Asn Gly Ile Arg His Cys Ser Tyr Thr Ala
            20                  25                  30          
Ser Arg Gln His Leu Tyr Val Asp Lys Asn Thr Lys Ile Ile Cys Gln
        35                  40                  45              
Gly Phe Thr Gly Lys Gln Gly Thr Phe His Ser Gln Gln Ala Leu Glu
    50                  55                  60                  
Tyr Gly Thr Lys Leu Val Gly Gly Thr Leu Pro Gly Lys Gly Gly Gln
65                  70                  75                  80  
Thr His Leu Gly Leu Pro Val Phe Asn Thr Val Lys Glu Ala Lys Glu
                85                  90                  95      
Gln Thr Gly Ala Thr Ala Ser Val Ile Tyr Val Pro Pro Pro Phe Ala
            100                 105                 110         
Ala Ala Ala Ile Asn Glu Ala Ile Glu Ala Glu Ile Pro Leu Val Val
        115                 120                 125             
Cys Ile Thr Glu Gly Ile Pro Gln Gln Asp Met Val Arg Val Lys His
    130                 135                 140                 
Lys Leu Leu Arg Gln Glu Lys Thr Arg Leu Ile Gly Pro Asn Cys Pro
145                 150                 155                 160 
Gly Val Ile Asn Pro Gly Glu Cys Lys Ile Gly Ile Met Pro Gly His
                165                 170                 175     
Ile His Lys Lys Gly Arg Ile Gly Ile Val Ser Arg Ser Gly Thr Leu
            180                 185                 190         
Thr Tyr Glu Ala Val His Gln Thr Thr Gln Val Gly Leu Gly Gln Ser
        195                 200                 205             
Leu Cys Val Gly Ile Gly Gly Asp Pro Phe Asn Gly Thr Asp Phe Ile
    210                 215                 220                 
Asp Cys Leu Glu Ile Phe Leu Asn Asp Ser Ala Thr Glu Gly Ile Ile
225                 230                 235                 240 
Leu Ile Gly Glu Ile Gly Gly Asn Ala Glu Glu Asn Ala Ala Glu Phe
                245                 250                 255     
Leu Lys Gln His Asn Ser Gly Pro Asn Ser Lys Pro Val Val Ser Phe
            260                 265                 270         
Ile Ala Gly Leu Thr Ala Pro Pro Gly Arg Arg Met Gly His Ala Gly
        275                 280                 285             
Ala Ile Ile Ala Gly Gly Lys Gly Gly Ala Lys Glu Lys Ile Ser Ala
    290                 295                 300                 
Leu Gln Ser Ala Gly Val Val Val Ser Met Ser Pro Ala Gln Leu Gly
305                 310                 315                 320 
Thr Thr Ile Tyr Lys Glu Phe Glu Lys Arg Lys Met Leu
                325                 330             


<210> 1170
<211> 463
<212> PRT
<213> Homo sapiens

<400> 1170
Met Ala Ala Ser Met Phe Tyr Gly Arg Leu Val Ala Val Ala Thr Leu
 1               5                  10                  15      
Arg Asn His Arg Pro Arg Thr Ala Gln Arg Ala Ala Ala Gln Val Leu
            20                  25                  30          
Gly Ser Ser Gly Leu Phe Asn Asn His Gly Leu Gln Val Gln Gln Gln
        35                  40                  45              
Gln Gln Arg Asn Leu Ser Leu His Glu Tyr Met Ser Met Glu Leu Leu
    50                  55                  60                  
Gln Glu Ala Gly Val Ser Val Pro Lys Gly Tyr Val Ala Lys Ser Pro
65                  70                  75                  80  
Asp Glu Ala Tyr Ala Ile Ala Lys Lys Leu Gly Ser Lys Asp Val Val
                85                  90                  95      
Ile Lys Ala Gln Val Leu Ala Gly Gly Arg Gly Lys Gly Thr Phe Glu
            100                 105                 110         
Ser Gly Leu Lys Gly Gly Val Lys Ile Val Phe Ser Pro Glu Glu Ala
        115                 120                 125             
Lys Ala Val Ser Ser Gln Met Ile Gly Lys Lys Leu Phe Thr Lys Gln
    130                 135                 140                 
Thr Gly Glu Lys Gly Arg Ile Cys Asn Gln Val Leu Val Cys Glu Arg
145                 150                 155                 160 
Lys Tyr Pro Arg Arg Glu Tyr Tyr Phe Ala Ile Thr Met Glu Arg Ser
                165                 170                 175     
Phe Gln Gly Pro Val Leu Ile Gly Ser Ser His Gly Gly Val Asn Ile
            180                 185                 190         
Glu Asp Val Ala Ala Glu Ser Pro Glu Ala Ile Ile Lys Glu Pro Ile
        195                 200                 205             
Asp Ile Glu Glu Gly Ile Lys Lys Glu Gln Ala Leu Gln Leu Ala Gln
    210                 215                 220                 
Lys Met Gly Phe Pro Pro Asn Ile Val Glu Ser Ala Ala Glu Asn Met
225                 230                 235                 240 
Val Lys Leu Tyr Ser Leu Phe Leu Lys Tyr Asp Ala Thr Met Ile Glu
                245                 250                 255     
Ile Asn Pro Met Val Glu Asp Ser Asp Gly Ala Val Leu Cys Met Asp
            260                 265                 270         
Ala Lys Ile Asn Phe Asp Ser Asn Ser Ala Tyr Arg Gln Lys Lys Ile
        275                 280                 285             
Phe Asp Leu Gln Asp Trp Thr Gln Glu Asp Glu Arg Asp Lys Asp Ala
    290                 295                 300                 
Ala Lys Ala Asn Leu Asn Tyr Ile Gly Leu Asp Gly Asn Ile Gly Cys
305                 310                 315                 320 
Leu Val Asn Gly Ala Gly Leu Ala Met Ala Thr Met Asp Ile Ile Lys
                325                 330                 335     
Leu His Gly Gly Thr Pro Ala Asn Phe Leu Asp Val Gly Gly Gly Ala
            340                 345                 350         
Thr Val His Gln Val Thr Glu Ala Phe Lys Leu Ile Thr Ser Asp Lys
        355                 360                 365             
Lys Val Leu Ala Ile Leu Val Asn Ile Phe Gly Gly Ile Met Arg Cys
    370                 375                 380                 
Asp Val Ile Ala Gln Gly Ile Val Met Ala Val Lys Asp Leu Glu Ile
385                 390                 395                 400 
Lys Ile Pro Val Val Val Arg Leu Gln Gly Thr Arg Val Asp Asp Ala
                405                 410                 415     
Lys Ala Leu Ile Ala Asp Ser Gly Leu Lys Ile Leu Ala Cys Asp Asp
            420                 425                 430         
Leu Asp Glu Ala Ala Arg Met Val Val Lys Leu Ser Glu Ile Val Thr
        435                 440                 445             
Leu Ala Lys Gln Ala His Val Asp Val Lys Phe Gln Leu Pro Ile
    450                 455                 460             


<210> 1171
<211> 331
<212> PRT
<213> Homo sapiens

<400> 1171
Met Arg Phe Arg Phe Gly Val Val Val Pro Pro Ala Val Ala Gly Ala
 1               5                  10                  15      
Arg Pro Glu Leu Leu Val Val Gly Ser Arg Pro Glu Leu Gly Arg Trp
            20                  25                  30          
Glu Pro Arg Gly Ala Val Arg Leu Arg Pro Ala Gly Thr Ala Ala Gly
        35                  40                  45              
Asp Gly Ala Leu Ala Leu Gln Glu Pro Gly Leu Trp Leu Gly Glu Val
    50                  55                  60                  
Glu Leu Ala Ala Glu Glu Ala Ala Gln Asp Gly Ala Glu Pro Gly Arg
65                  70                  75                  80  
Val Asp Thr Phe Trp Tyr Lys Phe Leu Lys Arg Glu Pro Gly Gly Glu
                85                  90                  95      
Leu Ser Trp Glu Gly Asn Gly Pro His His Asp Arg Cys Cys Thr Tyr
            100                 105                 110         
Asn Glu Asn Asn Leu Val Asp Gly Val Tyr Cys Leu Pro Ile Gly His
        115                 120                 125             
Trp Ile Glu Ala Thr Gly His Thr Asn Glu Met Lys His Thr Thr Asp
    130                 135                 140                 
Phe Tyr Phe Asn Ile Ala Gly His Gln Ala Met His Tyr Ser Arg Ile
145                 150                 155                 160 
Leu Pro Asn Ile Trp Leu Gly Ser Cys Pro Arg Gln Val Glu His Val
                165                 170                 175     
Thr Ile Lys Leu Lys His Glu Leu Gly Ile Thr Ala Val Met Asn Phe
            180                 185                 190         
Gln Thr Glu Trp Asp Ile Val Gln Asn Ser Ser Gly Cys Asn Arg Tyr
        195                 200                 205             
Pro Glu Pro Met Thr Pro Asp Thr Met Ile Lys Leu Tyr Arg Glu Glu
    210                 215                 220                 
Gly Leu Ala Tyr Ile Trp Met Pro Thr Pro Asp Met Ser Thr Glu Gly
225                 230                 235                 240 
Arg Val Gln Met Leu Pro Gln Ala Val Cys Leu Leu His Ala Leu Leu
                245                 250                 255     
Glu Lys Gly His Ile Val Tyr Val His Cys Asn Ala Gly Val Gly Arg
            260                 265                 270         
Ser Thr Ala Ala Val Cys Gly Trp Leu Gln Tyr Val Met Gly Trp Asn
        275                 280                 285             
Leu Arg Lys Val Gln Tyr Phe Leu Met Ala Lys Arg Pro Ala Val Tyr
    290                 295                 300                 
Ile Asp Glu Glu Ala Leu Ala Arg Ala Gln Glu Asp Phe Phe Gln Lys
305                 310                 315                 320 
Phe Gly Lys Val Arg Ser Ser Val Cys Ser Leu
                325                 330     


<210> 1172
<211> 722
<212> PRT
<213> Homo sapiens

<400> 1172
Met Ser Leu Ser Met Arg Asp Pro Val Ile Pro Gly Thr Ser Met Ala
 1               5                  10                  15      
Tyr His Pro Phe Leu Pro His Arg Ala Pro Asp Phe Ala Met Ser Ala
            20                  25                  30          
Val Leu Gly His Gln Pro Pro Phe Phe Pro Ala Leu Thr Leu Pro Pro
        35                  40                  45              
Asn Gly Ala Ala Ala Leu Ser Leu Pro Gly Ala Leu Ala Lys Pro Ile
    50                  55                  60                  
Met Asp Gln Leu Val Gly Ala Ala Glu Thr Gly Ile Pro Phe Ser Ser
65                  70                  75                  80  
Leu Gly Pro Gln Ala His Leu Arg Pro Leu Lys Thr Met Glu Pro Glu
                85                  90                  95      
Glu Glu Val Glu Asp Asp Pro Lys Val His Leu Glu Ala Lys Glu Leu
            100                 105                 110         
Trp Asp Gln Phe His Lys Arg Gly Thr Glu Met Val Ile Thr Lys Ser
        115                 120                 125             
Gly Arg Arg Met Phe Pro Pro Phe Lys Val Arg Cys Ser Gly Leu Asp
    130                 135                 140                 
Lys Lys Ala Lys Tyr Ile Leu Leu Met Asp Ile Ile Ala Ala Asp Asp
145                 150                 155                 160 
Cys Arg Tyr Lys Phe His Asn Ser Arg Trp Met Val Ala Gly Lys Ala
                165                 170                 175     
Asp Pro Glu Met Pro Lys Arg Met Tyr Ile His Pro Asp Ser Pro Ala
            180                 185                 190         
Thr Gly Glu Gln Trp Met Ser Lys Val Val Thr Phe His Lys Leu Lys
        195                 200                 205             
Leu Thr Asn Asn Ile Ser Asp Lys His Gly Phe Thr Ile Leu Asn Ser
    210                 215                 220                 
Met His Lys Tyr Gln Pro Arg Phe His Ile Val Arg Ala Asn Asp Ile
225                 230                 235                 240 
Leu Lys Leu Pro Tyr Ser Thr Phe Arg Thr Tyr Leu Phe Pro Glu Thr
                245                 250                 255     
Glu Phe Ile Ala Val Thr Ala Tyr Gln Asn Asp Lys Ile Thr Gln Leu
            260                 265                 270         
Lys Ile Asp Asn Asn Pro Phe Ala Lys Gly Phe Arg Asp Thr Gly Asn
        275                 280                 285             
Gly Arg Arg Glu Lys Arg Lys Gln Leu Thr Leu Gln Ser Met Arg Val
    290                 295                 300                 
Phe Asp Glu Arg His Lys Lys Glu Asn Gly Thr Ser Asp Glu Ser Ser
305                 310                 315                 320 
Ser Glu Gln Ala Ala Phe Asn Cys Phe Ala Gln Ala Ser Ser Pro Ala
                325                 330                 335     
Ala Ser Thr Val Gly Thr Ser Asn Leu Lys Asp Leu Cys Pro Ser Glu
            340                 345                 350         
Gly Glu Ser Asp Ala Glu Ala Glu Ser Lys Glu Glu His Gly Pro Glu
        355                 360                 365             
Ala Cys Asp Ala Ala Lys Ile Ser Thr Thr Thr Ser Glu Glu Pro Cys
    370                 375                 380                 
Arg Asp Lys Gly Ser Pro Ala Val Lys Ala His Leu Phe Ala Ala Glu
385                 390                 395                 400 
Arg Pro Arg Asp Ser Gly Arg Leu Asp Lys Ala Ser Pro Asp Ser Arg
                405                 410                 415     
His Ser Pro Ala Thr Ile Ser Ser Ser Thr Arg Gly Leu Gly Ala Glu
            420                 425                 430         
Glu Arg Arg Ser Pro Val Arg Glu Gly Thr Ala Pro Ala Lys Val Glu
        435                 440                 445             
Glu Ala Arg Ala Leu Pro Gly Lys Glu Ala Phe Ala Pro Leu Thr Val
    450                 455                 460                 
Gln Thr Asp Ala Ala Ala Ala His Leu Ala Gln Gly Pro Leu Pro Gly
465                 470                 475                 480 
Leu Gly Phe Ala Pro Gly Leu Ala Gly Gln Gln Phe Phe Asn Gly His
                485                 490                 495     
Pro Leu Phe Leu His Pro Ser Gln Phe Ala Met Gly Gly Ala Phe Ser
            500                 505                 510         
Ser Met Ala Ala Ala Gly Met Gly Pro Leu Leu Ala Thr Val Ser Gly
        515                 520                 525             
Ala Ser Thr Gly Val Ser Gly Leu Asp Ser Thr Ala Met Ala Ser Ala
    530                 535                 540                 
Ala Ala Ala Gln Gly Leu Ser Gly Ala Ser Ala Ala Thr Leu Pro Phe
545                 550                 555                 560 
His Leu Gln Gln His Val Leu Ala Ser Gln Gly Leu Ala Met Ser Pro
                565                 570                 575     
Phe Gly Ser Leu Phe Pro Tyr Pro Tyr Thr Tyr Met Ala Ala Ala Ala
            580                 585                 590         
Ala Ala Ser Leu Arg Gln Pro Gln Leu Arg Cys Thr Ala Pro Leu Leu
        595                 600                 605             
Asn Leu Asn Thr Met Arg Pro Arg Leu Arg Tyr Ser Pro Tyr Ser Ile
    610                 615                 620                 
Pro Val Pro Val Pro Asp Gly Ser Ser Leu Leu Thr Thr Ala Leu Pro
625                 630                 635                 640 
Ser Met Ala Ala Ala Ala Gly Pro Leu Asp Gly Lys Ala Ala Ala Leu
                645                 650                 655     
Ala Ala Ser Pro Ala Ser Val Ala Val Asp Ser Gly Ser Glu Pro Asn
            660                 665                 670         
Ser Arg Ser Ser Thr Leu Ser Ser Ser Ser Met Ser Leu Ser Pro Lys
        675                 680                 685             
Leu Cys Ala Glu Lys Glu Ala Ala Thr Ser Glu Leu Gln Ser Ile Gln
    690                 695                 700                 
Arg Leu Val Ser Gly Leu Glu Ala Lys Pro Asp Arg Ser Arg Ser Ala
705                 710                 715                 720 
Ser Pro
        


<210> 1173
<211> 147
<212> PRT
<213> Homo sapiens

<400> 1173
Met Ala Ala Thr Thr Gly Ser Gly Val Lys Val Pro Arg Asn Phe Arg
 1               5                  10                  15      
Leu Leu Glu Glu Leu Glu Glu Gly Gln Lys Gly Val Gly Asp Gly Thr
            20                  25                  30          
Val Ser Trp Gly Leu Glu Asp Asp Glu Asp Met Thr Leu Thr Arg Trp
        35                  40                  45              
Thr Gly Met Ile Ile Gly Pro Pro Arg Thr Ile Tyr Glu Asn Arg Ile
    50                  55                  60                  
Tyr Ser Leu Lys Ile Glu Cys Gly Pro Lys Tyr Pro Glu Ala Pro Pro
65                  70                  75                  80  
Phe Val Arg Phe Val Thr Lys Ile Asn Met Asn Gly Val Asn Ser Ser
                85                  90                  95      
Asn Gly Val Val Asp Pro Arg Ala Ile Ser Val Leu Ala Lys Trp Gln
            100                 105                 110         
Asn Ser Tyr Ser Ile Lys Val Val Leu Gln Glu Leu Arg Arg Leu Met
        115                 120                 125             
Met Ser Lys Glu Asn Met Lys Leu Pro Gln Pro Pro Glu Gly Gln Cys
    130                 135                 140                 
Tyr Ser Asn
145         


<210> 1174
<211> 619
<212> PRT
<213> Homo sapiens

<400> 1174
Leu Val Gly Glu Pro Leu Pro Ser Gln Val Pro Pro Gly Cys Cys Pro
 1               5                  10                  15      
Arg Ala Pro Gly Arg Pro Pro Pro Gly Arg Gly Ala Ala Ala Ala Gly
            20                  25                  30          
Ala Gly Asn Arg Ala Ala Val Ala Val Ala Val Ala Arg Ala Asp Glu
        35                  40                  45              
Ala Glu Ala Pro Phe Ala Gly Gln Asn Trp Leu Lys Ser Tyr Gly Tyr
    50                  55                  60                  
Leu Leu Pro Tyr Asp Ser Arg Ala Ser Ala Leu His Ser Ala Lys Ala
65                  70                  75                  80  
Leu Gln Ser Ala Val Ser Thr Met Gln Gln Phe Tyr Gly Ile Pro Val
                85                  90                  95      
Thr Gly Val Leu Asp Gln Thr Thr Ile Glu Trp Met Lys Lys Pro Arg
            100                 105                 110         
Cys Gly Val Pro Asp His Pro His Leu Ser Arg Arg Arg Arg Asn Lys
        115                 120                 125             
Arg Tyr Ala Leu Thr Gly Gln Lys Trp Arg Gln Lys His Ile Thr Tyr
    130                 135                 140                 
Ser Ile His Asn Tyr Thr Pro Lys Val Gly Glu Leu Asp Thr Arg Lys
145                 150                 155                 160 
Ala Ile Arg Gln Ala Phe Asp Val Trp Gln Lys Val Thr Pro Leu Thr
                165                 170                 175     
Phe Glu Glu Val Pro Tyr His Glu Ile Lys Ser Asp Arg Lys Glu Ala
            180                 185                 190         
Asp Ile Met Ile Phe Phe Ala Ser Gly Phe His Gly Asp Ser Ser Pro
        195                 200                 205             
Phe Asp Gly Glu Gly Gly Phe Leu Ala His Ala Tyr Phe Pro Gly Pro
    210                 215                 220                 
Gly Ile Gly Gly Asp Thr His Phe Asp Ser Asp Glu Pro Trp Thr Leu
225                 230                 235                 240 
Gly Asn Ala Asn His Asp Gly Asn Asp Leu Phe Leu Val Ala Val His
                245                 250                 255     
Glu Leu Gly His Ala Leu Gly Leu Glu His Ser Ser Asp Pro Ser Ala
            260                 265                 270         
Ile Met Ala Pro Phe Tyr Gln Tyr Met Glu Thr His Asn Phe Lys Leu
        275                 280                 285             
Pro Gln Asp Asp Leu Gln Gly Ile Gln Lys Ile Tyr Gly Pro Pro Ala
    290                 295                 300                 
Glu Pro Leu Glu Pro Thr Arg Pro Leu Pro Thr Leu Pro Val Arg Arg
305                 310                 315                 320 
Ile His Ser Pro Ser Glu Arg Lys His Glu Arg Gln Pro Arg Pro Pro
                325                 330                 335     
Arg Pro Pro Leu Gly Asp Arg Pro Ser Thr Pro Gly Thr Lys Pro Asn
            340                 345                 350         
Ile Cys Asp Gly Asn Phe Asn Thr Val Ala Leu Phe Arg Gly Glu Met
        355                 360                 365             
Phe Val Phe Lys Asp Arg Trp Phe Trp Arg Leu Arg Asn Asn Arg Val
    370                 375                 380                 
Gln Glu Gly Tyr Pro Met Gln Ile Glu Gln Phe Trp Lys Gly Leu Pro
385                 390                 395                 400 
Ala Arg Ile Asp Ala Ala Tyr Glu Arg Ala Asp Gly Arg Phe Val Phe
                405                 410                 415     
Phe Lys Gly Asp Lys Tyr Trp Val Phe Lys Glu Val Thr Val Glu Pro
            420                 425                 430         
Gly Tyr Pro His Ser Leu Gly Glu Leu Gly Ser Cys Leu Pro Arg Glu
        435                 440                 445             
Gly Ile Asp Thr Ala Leu Arg Trp Glu Pro Val Gly Lys Thr Tyr Phe
    450                 455                 460                 
Phe Lys Gly Glu Arg Tyr Trp Arg Tyr Ser Glu Glu Arg Arg Ala Thr
465                 470                 475                 480 
Asp Pro Gly Tyr Pro Lys Pro Ile Thr Val Trp Lys Gly Ile Pro Gln
                485                 490                 495     
Ala Pro Gln Gly Ala Phe Ile Ser Lys Glu Gly Tyr Tyr Thr Tyr Phe
            500                 505                 510         
Tyr Lys Gly Arg Asp Tyr Trp Lys Phe Asp Asn Gln Lys Leu Ser Val
        515                 520                 525             
Glu Pro Gly Tyr Pro Arg Asn Ile Leu Arg Asp Trp Met Gly Cys Asn
    530                 535                 540                 
Gln Lys Glu Val Glu Arg Arg Lys Glu Arg Arg Leu Pro Gln Asp Asp
545                 550                 555                 560 
Val Asp Ile Met Val Thr Ile Asn Asp Val Pro Gly Ser Val Asn Ala
                565                 570                 575     
Val Ala Val Val Ile Pro Cys Ile Leu Ser Leu Cys Ile Leu Val Leu
            580                 585                 590         
Val Tyr Thr Ile Phe Gln Phe Lys Asn Lys Thr Gly Pro Gln Pro Val
        595                 600                 605             
Thr Tyr Tyr Lys Arg Pro Val Gln Glu Trp Val
    610                 615                 


<210> 1175
<211> 1940
<212> PRT
<213> Homo sapiens

<400> 1175
Met Ser Ser Asp Thr Glu Met Glu Val Phe Gly Ile Ala Ala Pro Phe
 1               5                  10                  15      
Leu Arg Lys Ser Glu Lys Glu Arg Ile Glu Ala Gln Asn Gln Pro Phe
            20                  25                  30          
Asp Ala Lys Thr Tyr Cys Phe Val Val Asp Ser Lys Glu Glu Tyr Ala
        35                  40                  45              
Lys Gly Lys Ile Lys Ser Ser Gln Asp Gly Lys Val Thr Val Glu Thr
    50                  55                  60                  
Glu Asp Asn Arg Thr Leu Val Val Lys Pro Glu Asp Val Tyr Ala Met
65                  70                  75                  80  
Asn Pro Pro Lys Phe Asp Arg Ile Glu Asp Met Ala Met Leu Thr His
                85                  90                  95      
Leu Asn Glu Pro Ala Val Leu Tyr Asn Leu Lys Asp Arg Tyr Thr Ser
            100                 105                 110         
Trp Met Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Thr Val Asn Pro
        115                 120                 125             
Tyr Lys Trp Leu Pro Val Tyr Asn Pro Glu Val Val Glu Gly Tyr Arg
    130                 135                 140                 
Gly Lys Lys Arg Gln Glu Ala Pro Pro His Ile Phe Ser Ile Ser Asp
145                 150                 155                 160 
Asn Ala Tyr Gln Phe Met Leu Thr Asp Arg Glu Asn Gln Ser Ile Leu
                165                 170                 175     
Ile Thr Gly Glu Ser Gly Ala Gly Lys Thr Val Asn Thr Lys Arg Val
            180                 185                 190         
Ile Gln Tyr Phe Ala Thr Ile Ala Ala Thr Gly Asp Leu Ala Lys Lys
        195                 200                 205             
Lys Asp Ser Lys Met Lys Gly Thr Leu Glu Asp Gln Ile Ile Ser Ala
    210                 215                 220                 
Asn Pro Leu Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Arg Asn Asp
225                 230                 235                 240 
Asn Ser Ser Arg Phe Gly Lys Phe Ile Arg Ile His Phe Gly Thr Thr
                245                 250                 255     
Gly Lys Leu Ala Ser Ala Asp Ile Glu Thr Tyr Leu Leu Glu Lys Ser
            260                 265                 270         
Arg Val Thr Phe Gln Leu Lys Ala Glu Arg Ser Tyr His Ile Phe Tyr
        275                 280                 285             
Gln Ile Leu Ser Asn Lys Lys Pro Glu Leu Ile Glu Leu Leu Leu Ile
    290                 295                 300                 
Thr Thr Asn Pro Tyr Asp Tyr Pro Phe Ile Ser Gln Gly Glu Ile Leu
305                 310                 315                 320 
Val Ala Ser Ile Asp Asp Arg Glu Glu Leu Leu Ala Thr Asp Ser Ala
                325                 330                 335     
Ile Asp Ile Leu Gly Phe Thr Pro Glu Glu Lys Ser Gly Leu Tyr Lys
            340                 345                 350         
Leu Thr Gly Ala Val Met His Tyr Gly Asn Met Lys Phe Lys Gln Lys
        355                 360                 365             
Gln Arg Glu Glu Gln Ala Glu Pro Asp Gly Thr Glu Val Ala Asp Lys
    370                 375                 380                 
Thr Ala Tyr Leu Met Gly Leu Asn Ser Ser Asp Leu Leu Lys Ala Leu
385                 390                 395                 400 
Cys Phe Pro Arg Val Lys Val Gly Asn Glu Tyr Val Thr Lys Gly Gln
                405                 410                 415     
Thr Val Asp Gln Val His His Ala Val Asn Ala Leu Ser Lys Ser Val
            420                 425                 430         
Tyr Glu Lys Leu Phe Leu Trp Met Val Thr Arg Ile Asn Gln Gln Leu
        435                 440                 445             
Asp Thr Lys Leu Pro Arg Gln His Phe Ile Gly Val Leu Asp Ile Ala
    450                 455                 460                 
Gly Phe Glu Ile Phe Glu Tyr Asn Ser Leu Glu Gln Leu Cys Ile Asn
465                 470                 475                 480 
Phe Thr Asn Glu Lys Leu Gln Gln Phe Phe Asn His His Met Phe Val
                485                 490                 495     
Leu Glu Gln Glu Glu Tyr Lys Lys Glu Gly Ile Glu Trp Thr Phe Ile
            500                 505                 510         
Asp Phe Gly Met Asp Leu Ala Ala Cys Ile Glu Leu Ile Glu Lys Pro
        515                 520                 525             
Met Gly Ile Phe Ser Ile Leu Glu Glu Glu Cys Met Phe Pro Lys Ala
    530                 535                 540                 
Thr Asp Thr Ser Phe Lys Asn Lys Leu Tyr Asp Gln His Leu Gly Lys
545                 550                 555                 560 
Ser Asn Asn Phe Gln Lys Pro Lys Val Val Lys Gly Arg Ala Glu Ala
                565                 570                 575     
His Phe Ser Leu Ile His Tyr Ala Gly Thr Val Asp Tyr Ser Val Ser
            580                 585                 590         
Gly Trp Leu Glu Lys Asn Lys Asp Pro Leu Asn Glu Thr Val Val Gly
        595                 600                 605             
Leu Tyr Gln Lys Ser Ser Asn Arg Leu Leu Ala His Leu Tyr Ala Thr
    610                 615                 620                 
Phe Ala Thr Ala Asp Ala Asp Ser Gly Lys Lys Lys Val Ala Lys Lys
625                 630                 635                 640 
Lys Gly Ser Ser Phe Gln Thr Val Ser Ala Leu Phe Arg Glu Asn Leu
                645                 650                 655     
Asn Lys Leu Met Ser Asn Leu Arg Thr Thr His Pro His Phe Val Arg
            660                 665                 670         
Cys Ile Ile Pro Asn Glu Thr Lys Thr Pro Gly Ala Met Glu His Ser
        675                 680                 685             
Leu Val Leu His Gln Leu Arg Cys Asn Gly Val Leu Glu Gly Ile Arg
    690                 695                 700                 
Ile Cys Arg Lys Gly Phe Pro Asn Arg Ile Leu Tyr Gly Asp Phe Lys
705                 710                 715                 720 
Gln Arg Tyr Arg Val Leu Asn Ala Ser Ala Ile Leu Glu Gly Gln Phe
                725                 730                 735     
Ile Asp Ser Lys Lys Ala Cys Glu Lys Leu Leu Ala Ser Ile Asp Ile
            740                 745                 750         
Asp His Thr Gln Tyr Lys Phe Gly His Thr Lys Val Phe Phe Lys Ala
        755                 760                 765             
Gly Leu Leu Gly Thr Leu Glu Glu Met Arg Asp Asp Arg Leu Ala Lys
    770                 775                 780                 
Leu Ile Thr Arg Thr Gln Ala Val Cys Arg Gly Phe Leu Met Arg Val
785                 790                 795                 800 
Glu Phe Gln Lys Met Val Gln Arg Arg Glu Ser Ile Phe Cys Ile Gln
                805                 810                 815     
Tyr Asn Ile Arg Ser Phe Met Asn Val Lys His Trp Pro Trp Met Lys
            820                 825                 830         
Leu Phe Phe Lys Ile Lys Pro Leu Leu Lys Ser Ala Glu Thr Glu Lys
        835                 840                 845             
Glu Met Ala Thr Met Lys Glu Glu Phe Gln Lys Thr Lys Asp Glu Leu
    850                 855                 860                 
Ala Lys Ser Glu Ala Lys Arg Lys Glu Leu Glu Glu Lys Leu Val Thr
865                 870                 875                 880 
Leu Val Gln Glu Lys Asn Asp Leu Gln Leu Gln Val Gln Ala Glu Ser
                885                 890                 895     
Glu Asn Leu Leu Asp Ala Glu Glu Arg Cys Asp Gln Leu Ile Lys Ala
            900                 905                 910         
Lys Phe Gln Leu Glu Ala Lys Ile Lys Glu Val Thr Glu Arg Ala Glu
        915                 920                 925             
Asp Glu Glu Glu Ile Asn Ala Glu Leu Thr Ala Lys Lys Arg Lys Leu
    930                 935                 940                 
Glu Asp Glu Cys Ser Glu Leu Lys Lys Asp Ile Asp Asp Leu Glu Leu
945                 950                 955                 960 
Thr Leu Ala Lys Val Glu Lys Glu Lys His Ala Thr Glu Asn Lys Val
                965                 970                 975     
Lys Asn Leu Thr Glu Glu Leu Ser Gly Leu Asp Glu Thr Ile Ala Lys
            980                 985                 990         
Leu Thr Arg Glu Lys Lys Ala Leu Gln Glu Ala His Gln Gln Ala Leu
        995                 1000                1005            
Asp Asp Leu Gln Ala Glu Glu Asp Lys Val Asn Ser Leu Asn Lys Thr
    1010                1015                1020                
Lys Ser Lys Leu Glu Gln Gln Val Glu Asp Leu Glu Ser Ser Leu Glu
1025                1030                1035                1040
Gln Glu Lys Lys Leu Arg Val Asp Leu Glu Arg Asn Lys Arg Lys Leu
                1045                1050                1055    
Glu Gly Asp Leu Lys Leu Ala Gln Glu Ser Ile Leu Asp Leu Glu Asn
            1060                1065                1070        
Asp Lys Gln Gln Leu Asp Glu Arg Leu Lys Lys Lys Asp Phe Glu Tyr
        1075                1080                1085            
Cys Gln Leu Gln Ser Lys Val Glu Asp Glu Gln Thr Leu Gly Leu Gln
    1090                1095                1100                
Phe Gln Lys Lys Ile Lys Glu Leu Gln Ala Arg Ile Glu Glu Leu Glu
1105                1110                1115                1120
Glu Glu Ile Glu Ala Glu Arg Ala Thr Arg Ala Lys Thr Glu Lys Gln
                1125                1130                1135    
Arg Ser Asp Tyr Ala Arg Glu Leu Glu Glu Leu Ser Glu Arg Leu Glu
            1140                1145                1150        
Glu Ala Gly Gly Val Thr Ser Thr Gln Ile Glu Leu Asn Lys Lys Arg
        1155                1160                1165            
Glu Ala Glu Phe Leu Lys Leu Arg Arg Asp Leu Glu Glu Ala Thr Leu
    1170                1175                1180                
Gln His Glu Ala Met Val Ala Thr Leu Arg Lys Lys His Ala Asp Ser
1185                1190                1195                1200
Val Ala Glu Leu Gly Glu Gln Ile Asp Asn Leu Gln Arg Val Lys Gln
                1205                1210                1215    
Lys Leu Glu Lys Glu Lys Ser Glu Phe Lys Leu Glu Ile Asp Asp Leu
            1220                1225                1230        
Ser Ser Ser Met Glu Ser Val Ser Lys Ser Lys Ala Asn Leu Glu Lys
        1235                1240                1245            
Ile Cys Arg Thr Leu Glu Asp Gln Leu Ser Glu Ala Arg Gly Lys Asn
    1250                1255                1260                
Glu Glu Ile Gln Arg Ser Leu Ser Glu Leu Thr Thr Gln Lys Ser Arg
1265                1270                1275                1280
Leu Gln Thr Glu Ala Gly Glu Leu Ser Arg Gln Leu Glu Glu Lys Glu
                1285                1290                1295    
Ser Ile Val Ser Gln Leu Ser Arg Ser Lys Gln Ala Phe Thr Gln Gln
            1300                1305                1310        
Thr Glu Glu Leu Lys Arg Gln Leu Glu Glu Glu Asn Lys Ala Lys Asn
        1315                1320                1325            
Ala Leu Ala His Ala Leu Gln Ser Ser Arg His Asp Cys Asp Leu Leu
    1330                1335                1340                
Arg Glu Gln Tyr Glu Glu Glu Gln Glu Gly Lys Ala Glu Leu Gln Arg
1345                1350                1355                1360
Ala Leu Ser Lys Ala Asn Ser Glu Val Ala Gln Trp Arg Thr Lys Tyr
                1365                1370                1375    
Glu Thr Asp Ala Ile Gln Arg Thr Glu Glu Leu Glu Glu Ala Gln Glu
            1380                1385                1390        
Lys Leu Ala Gln Arg Leu Gln Asp Ser Glu Glu Gln Val Glu Ala Val
        1395                1400                1405            
Asn Ala Lys Cys Ala Ser Leu Glu Lys Thr Lys Gln Arg Leu Gln Gly
    1410                1415                1420                
Glu Val Glu Asp Leu Met Val Asp Val Glu Arg Ala Asn Ser Leu Ala
1425                1430                1435                1440
Ala Ala Leu Asp Lys Lys Gln Arg Asn Phe Asp Lys Val Leu Ala Glu
                1445                1450                1455    
Trp Lys Thr Lys Cys Glu Glu Ser Gln Ala Glu Leu Glu Ala Ser Leu
            1460                1465                1470        
Lys Glu Ser Arg Ser Leu Ser Thr Glu Leu Phe Lys Leu Lys Asn Ala
        1475                1480                1485            
Tyr Glu Glu Ala Leu Asp Gln Leu Glu Thr Val Lys Arg Glu Asn Lys
    1490                1495                1500                
Asn Leu Glu Gln Glu Ile Ala Asp Leu Thr Glu Gln Ile Ala Glu Asn
1505                1510                1515                1520
Gly Lys Thr Ile His Glu Leu Glu Lys Ser Arg Lys Gln Ile Glu Leu
                1525                1530                1535    
Glu Lys Ala Asp Ile Gln Leu Ala Leu Glu Glu Ala Glu Ala Ala Leu
            1540                1545                1550        
Glu His Glu Glu Ala Lys Ile Leu Arg Ile Gln Leu Glu Leu Thr Gln
        1555                1560                1565            
Val Lys Ser Glu Ile Asp Arg Lys Ile Ala Glu Lys Asp Glu Glu Ile
    1570                1575                1580                
Glu Gln Leu Lys Arg Asn Tyr Gln Arg Thr Val Glu Thr Met Gln Ser
1585                1590                1595                1600
Ala Leu Asp Ala Glu Val Arg Ser Arg Asn Glu Ala Ile Arg Leu Lys
                1605                1610                1615    
Lys Lys Met Glu Gly Asp Leu Asn Glu Ile Glu Ile Gln Leu Ser His
            1620                1625                1630        
Ala Asn Arg Gln Ala Ala Glu Thr Leu Lys His Leu Arg Ser Val Gln
        1635                1640                1645            
Gly Gln Leu Lys Asp Thr Gln Leu His Leu Asp Asp Ala Leu Arg Gly
    1650                1655                1660                
Gln Glu Asp Leu Lys Glu Gln Leu Ala Ile Val Glu Arg Arg Ala Asn
1665                1670                1675                1680
Leu Leu Gln Ala Glu Val Glu Glu Leu Arg Ala Thr Leu Glu Gln Thr
                1685                1690                1695    
Glu Arg Ala Arg Lys Leu Ala Glu Gln Glu Leu Leu Asp Ser Asn Glu
            1700                1705                1710        
Arg Val Gln Leu Leu His Thr Gln Asn Thr Ser Leu Ile His Thr Lys
        1715                1720                1725            
Lys Lys Leu Glu Thr Asp Leu Met Gln Leu Gln Ser Glu Val Glu Asp
    1730                1735                1740                
Ala Ser Arg Asp Ala Arg Asn Ala Glu Glu Lys Ala Lys Lys Ala Ile
1745                1750                1755                1760
Thr Asp Ala Ala Met Met Ala Glu Glu Leu Lys Lys Glu Gln Asp Thr
                1765                1770                1775    
Ser Ala His Leu Glu Arg Met Lys Lys Asn Leu Glu Gln Thr Val Lys
            1780                1785                1790        
Asp Leu Gln His Arg Leu Asp Glu Ala Glu Gln Leu Ala Leu Lys Gly
        1795                1800                1805            
Gly Lys Lys Gln Ile Gln Lys Leu Glu Thr Arg Ile Arg Glu Leu Glu
    1810                1815                1820                
Phe Glu Leu Glu Gly Glu Gln Lys Lys Asn Thr Glu Ser Val Lys Gly
1825                1830                1835                1840
Leu Arg Lys Tyr Glu Arg Arg Val Lys Glu Leu Thr Tyr Gln Ser Glu
                1845                1850                1855    
Glu Asp Arg Lys Asn Val Leu Arg Leu Gln Asp Leu Val Asp Lys Leu
            1860                1865                1870        
Gln Val Lys Val Lys Ser Tyr Lys Arg Gln Ala Glu Glu Ala Asp Glu
        1875                1880                1885            
Gln Ala Asn Ala His Leu Thr Lys Phe Arg Lys Ala Gln His Glu Leu
    1890                1895                1900                
Glu Glu Ala Glu Glu Arg Ala Asp Ile Ala Glu Ser Gln Val Asn Lys
1905                1910                1915                1920
Leu Arg Ala Lys Thr Arg Asp Phe Thr Ser Ser Arg Met Val Val His
                1925                1930                1935    
Glu Ser Glu Glu
            1940


<210> 1176
<211> 481
<212> PRT
<213> Homo sapiens

<400> 1176
Met Gly Ala Leu Ala Arg Ala Leu Pro Ser Ile Leu Leu Ala Leu Leu
 1               5                  10                  15      
Leu Thr Ser Thr Pro Glu Ala Leu Gly Ala Asn Pro Gly Leu Val Ala
            20                  25                  30          
Arg Ile Thr Asp Lys Gly Leu Gln Tyr Ala Ala Gln Glu Gly Leu Leu
        35                  40                  45              
Ala Leu Gln Ser Glu Leu Leu Arg Ile Thr Leu Pro Asp Phe Thr Gly
    50                  55                  60                  
Asp Leu Arg Ile Pro His Val Gly Arg Gly Arg Tyr Glu Phe His Ser
65                  70                  75                  80  
Leu Asn Ile His Ser Cys Glu Leu Leu His Ser Ala Leu Arg Pro Val
                85                  90                  95      
Pro Gly Gln Gly Leu Ser Leu Ser Ile Ser Asp Ser Ser Ile Arg Val
            100                 105                 110         
Gln Gly Arg Trp Lys Val Arg Lys Ser Phe Phe Lys Leu Gln Gly Ser
        115                 120                 125             
Phe Asp Val Ser Val Lys Gly Ile Ser Ile Ser Val Asn Leu Leu Leu
    130                 135                 140                 
Gly Ser Glu Ser Ser Gly Arg Pro Thr Val Thr Ala Ser Ser Cys Ser
145                 150                 155                 160 
Ser Asp Ile Ala Asp Val Glu Val Asp Met Ser Gly Asp Leu Gly Trp
                165                 170                 175     
Leu Leu Asn Leu Phe His Asn Gln Ile Glu Ser Lys Phe Gln Lys Val
            180                 185                 190         
Leu Glu Ser Arg Ile Cys Glu Met Ile Gln Lys Ser Val Ser Ser Asp
        195                 200                 205             
Leu Gln Pro Tyr Leu Gln Thr Leu Pro Val Thr Thr Glu Ile Asp Ser
    210                 215                 220                 
Phe Ala Asp Ile Asp Tyr Ser Leu Val Glu Ala Pro Arg Ala Thr Ala
225                 230                 235                 240 
Gln Met Leu Glu Val Met Phe Lys Gly Glu Ile Phe His Arg Asn His
                245                 250                 255     
Arg Ser Pro Val Thr Leu Leu Ala Ala Val Met Ser Leu Pro Glu Glu
            260                 265                 270         
His Asn Lys Met Val Tyr Phe Ala Ile Ser Asp Tyr Val Phe Asn Thr
        275                 280                 285             
Ala Ser Leu Val Tyr His Glu Glu Gly Tyr Leu Asn Phe Ser Ile Thr
    290                 295                 300                 
Asp Asp Met Ile Pro Pro Asp Ser Asn Ile Arg Leu Thr Thr Lys Ser
305                 310                 315                 320 
Phe Arg Pro Phe Val Pro Arg Leu Ala Arg Leu Tyr Pro Asn Met Asn
                325                 330                 335     
Leu Glu Leu Gln Gly Ser Val Pro Ser Ala Pro Leu Leu Asn Phe Ser
            340                 345                 350         
Pro Gly Asn Leu Ser Val Asp Pro Tyr Met Glu Ile Asp Ala Phe Val
        355                 360                 365             
Leu Leu Pro Ser Ser Ser Lys Glu Pro Val Phe Arg Leu Ser Val Ala
    370                 375                 380                 
Thr Asn Val Ser Ala Thr Leu Thr Phe Asn Thr Ser Lys Ile Thr Gly
385                 390                 395                 400 
Phe Leu Lys Pro Gly Lys Val Lys Val Glu Leu Lys Glu Ser Lys Val
                405                 410                 415     
Gly Leu Phe Asn Ala Glu Leu Leu Glu Ala Leu Leu Asn Tyr Tyr Ile
            420                 425                 430         
Leu Asn Thr Leu Tyr Pro Lys Phe Asn Asp Lys Leu Ala Glu Gly Phe
        435                 440                 445             
Pro Leu Pro Leu Leu Lys Arg Val Gln Leu Tyr Asp Leu Gly Leu Gln
    450                 455                 460                 
Ile His Lys Asp Phe Leu Phe Leu Gly Ala Asn Val Gln Tyr Met Arg
465                 470                 475                 480 
Val
    


<210> 1177
<211> 504
<212> PRT
<213> Homo sapiens

<400> 1177
Met Thr Pro Ser Pro Leu Leu Leu Leu Leu Leu Pro Pro Leu Leu Leu
 1               5                  10                  15      
Gly Ala Phe Pro Pro Ala Ala Ala Ala Arg Gly Pro Pro Lys Met Ala
            20                  25                  30          
Asp Lys Val Val Pro Arg Gln Val Ala Arg Leu Gly Arg Thr Val Arg
        35                  40                  45              
Leu Gln Cys Pro Val Glu Gly Asp Pro Pro Pro Leu Thr Met Trp Thr
    50                  55                  60                  
Lys Asp Gly Arg Thr Ile His Ser Gly Trp Ser Arg Phe Arg Val Leu
65                  70                  75                  80  
Pro Gln Gly Leu Lys Val Lys Gln Val Glu Arg Glu Asp Ala Gly Val
                85                  90                  95      
Tyr Val Cys Lys Ala Thr Asn Gly Phe Gly Ser Leu Ser Val Asn Tyr
            100                 105                 110         
Thr Leu Val Val Leu Asp Asp Ile Ser Pro Gly Lys Glu Ser Leu Gly
        115                 120                 125             
Pro Asp Ser Ser Ser Gly Gly Gln Glu Asp Pro Ala Ser Gln Gln Trp
    130                 135                 140                 
Ala Arg Pro Arg Phe Thr Gln Pro Ser Lys Met Arg Arg Arg Val Ile
145                 150                 155                 160 
Ala Arg Pro Val Gly Ser Ser Val Arg Leu Lys Cys Val Ala Ser Gly
                165                 170                 175     
His Pro Arg Pro Asp Ile Thr Trp Met Lys Asp Asp Gln Ala Leu Thr
            180                 185                 190         
Arg Pro Glu Ala Ala Glu Pro Arg Lys Lys Lys Trp Thr Leu Ser Leu
        195                 200                 205             
Lys Asn Leu Arg Pro Glu Asp Ser Gly Lys Tyr Thr Cys Arg Val Ser
    210                 215                 220                 
Asn Arg Ala Gly Ala Ile Asn Ala Thr Tyr Lys Val Asp Val Ile Gln
225                 230                 235                 240 
Arg Thr Arg Ser Lys Pro Val Leu Thr Gly Thr His Pro Val Asn Thr
                245                 250                 255     
Thr Val Asp Phe Gly Gly Thr Thr Ser Phe Gln Cys Lys Val Arg Ser
            260                 265                 270         
Asp Val Lys Pro Val Ile Gln Trp Leu Lys Arg Val Glu Tyr Gly Ala
        275                 280                 285             
Glu Gly Arg His Asn Ser Thr Ile Asp Val Gly Gly Gln Lys Phe Val
    290                 295                 300                 
Val Leu Pro Thr Gly Asp Val Trp Ser Arg Pro Asp Gly Ser Tyr Leu
305                 310                 315                 320 
Asn Lys Leu Leu Ile Thr Arg Ala Arg Gln Asp Asp Ala Gly Met Tyr
                325                 330                 335     
Ile Cys Leu Gly Ala Asn Thr Met Gly Tyr Ser Phe Arg Ser Ala Phe
            340                 345                 350         
Leu Thr Val Leu Pro Asp Pro Lys Pro Gln Gly Pro Pro Val Ala Ser
        355                 360                 365             
Ser Ser Ser Ala Thr Ser Leu Pro Trp Pro Val Val Ile Gly Ile Pro
    370                 375                 380                 
Ala Gly Ala Val Phe Ile Leu Gly Thr Leu Leu Leu Trp Leu Cys Gln
385                 390                 395                 400 
Ala Gln Lys Lys Pro Cys Thr Pro Ala Pro Ala Pro Pro Leu Pro Gly
                405                 410                 415     
His Arg Pro Pro Gly Thr Ala Arg Asp Arg Ser Gly Asp Lys Asp Leu
            420                 425                 430         
Pro Ser Leu Ala Ala Leu Ser Ala Gly Pro Gly Val Gly Leu Cys Glu
        435                 440                 445             
Glu His Gly Ser Pro Ala Ala Pro Gln His Leu Leu Gly Pro Gly Pro
    450                 455                 460                 
Val Ala Gly Pro Lys Leu Tyr Pro Lys Leu Tyr Thr Asp Ile His Thr
465                 470                 475                 480 
His Thr His Thr His Ser His Thr His Ser His Val Glu Gly Lys Val
                485                 490                 495     
His Gln His Ile His Tyr Gln Cys
            500                 


<210> 1178
<211> 437
<212> PRT
<213> Homo sapiens

<400> 1178
Met Ala Thr Arg Ser Cys Arg Glu Lys Ala Gln Lys Leu Asn Glu Gln
 1               5                  10                  15      
His Gln Leu Ile Leu Ser Lys Leu Leu Arg Glu Glu Asp Asn Lys Tyr
            20                  25                  30          
Cys Ala Asp Cys Glu Ala Lys Gly Pro Arg Trp Ala Ser Trp Asn Ile
        35                  40                  45              
Gly Val Phe Ile Cys Ile Arg Cys Ala Gly Ile His Arg Asn Leu Gly
    50                  55                  60                  
Val His Ile Ser Arg Val Lys Ser Val Asn Leu Asp Gln Trp Thr Ala
65                  70                  75                  80  
Glu Gln Ile Gln Cys Met Gln Asp Met Gly Asn Thr Lys Ala Arg Leu
                85                  90                  95      
Leu Tyr Glu Ala Asn Leu Pro Glu Asn Phe Arg Arg Pro Gln Thr Asp
            100                 105                 110         
Gln Ala Val Glu Phe Phe Ile Arg Asp Lys Tyr Glu Lys Lys Lys Tyr
        115                 120                 125             
Tyr Asp Lys Asn Ala Ile Ala Ile Thr Asn Lys Glu Lys Glu Lys Lys
    130                 135                 140                 
Lys Glu Glu Lys Lys Arg Glu Lys Glu Pro Glu Lys Pro Ala Lys Pro
145                 150                 155                 160 
Leu Thr Ala Glu Lys Leu Gln Lys Lys Asp Gln Gln Leu Glu Pro Lys
                165                 170                 175     
Lys Ser Thr Ser Pro Lys Lys Ala Ala Glu Pro Thr Val Asp Leu Leu
            180                 185                 190         
Gly Leu Asp Gly Pro Ala Val Ala Pro Val Thr Asn Gly Asn Thr Thr
        195                 200                 205             
Val Pro Pro Leu Asn Asp Asp Leu Asp Ile Phe Gly Pro Met Ile Ser
    210                 215                 220                 
Asn Pro Leu Pro Ala Thr Val Met Pro Pro Ala Gln Gly Thr Pro Ser
225                 230                 235                 240 
Ala Pro Ala Ala Ala Thr Leu Ser Thr Val Thr Ser Gly Asp Leu Asp
                245                 250                 255     
Leu Phe Thr Glu Gln Thr Thr Lys Ser Glu Glu Val Ala Lys Lys Gln
            260                 265                 270         
Leu Ser Lys Asp Ser Ile Leu Ser Leu Tyr Gly Thr Gly Thr Ile Gln
        275                 280                 285             
Gln Gln Ser Thr Pro Gly Val Phe Met Gly Pro Thr Asn Ile Pro Phe
    290                 295                 300                 
Thr Ser Gln Ala Pro Ala Ala Phe Gln Gly Phe Pro Ser Met Gly Val
305                 310                 315                 320 
Pro Val Pro Ala Ala Pro Gly Leu Ile Gly Asn Val Met Gly Gln Ser
                325                 330                 335     
Pro Ser Met Met Val Gly Met Pro Met Pro Asn Gly Phe Met Gly Asn
            340                 345                 350         
Ala Gln Thr Gly Val Met Pro Leu Pro Gln Asn Val Val Gly Pro Gln
        355                 360                 365             
Gly Gly Met Val Gly Gln Met Gly Ala Pro Gln Ser Lys Phe Gly Leu
    370                 375                 380                 
Pro Gln Ala Gln Gln Pro Gln Trp Ser Leu Ser Gln Ile Met Gln Lys
385                 390                 395                 400 
Gly Asp Ala Val Leu Gln His Ser Ile Ile Ser Ala Ile Tyr Trp Pro
                405                 410                 415     
Thr Thr Arg Trp Leu Lys Cys Pro Leu Val Asp Glu Ser Ala Asp Gly
            420                 425                 430         
Trp His Glu Tyr Gln
        435         


<210> 1179
<211> 2131
<212> PRT
<213> Homo sapiens

<400> 1179
Glu Pro Pro Glu Asp Asp Ala Asn Ile Ile Glu Lys Ile Leu Ala Ser
 1               5                  10                  15      
Lys Thr Val Gln Glu Val His Pro Gly Glu Pro Pro Phe Asp Leu Glu
            20                  25                  30          
Leu Phe Tyr Val Lys Tyr Arg Asn Phe Ser Tyr Leu His Cys Lys Trp
        35                  40                  45              
Ala Thr Met Glu Glu Leu Glu Lys Asp Pro Arg Ile Ala Gln Lys Ile
    50                  55                  60                  
Lys Arg Phe Arg Asn Lys Gln Ala Gln Met Lys His Ile Phe Thr Glu
65                  70                  75                  80  
Pro Asp Glu Asp Leu Phe Asn Pro Asp Tyr Val Glu Val Asp Arg Ile
                85                  90                  95      
Leu Glu Val Ala His Thr Lys Asp Ala Glu Thr Gly Glu Glu Val Thr
            100                 105                 110         
His Tyr Leu Val Lys Trp Cys Ser Leu Pro Tyr Glu Glu Ser Thr Trp
        115                 120                 125             
Glu Leu Glu Glu Asp Val Asp Pro Ala Lys Val Lys Glu Phe Glu Ser
    130                 135                 140                 
Leu Gln Val Leu Pro Glu Ile Lys His Val Glu Arg Pro Ala Ser Asp
145                 150                 155                 160 
Ser Trp Gln Lys Leu Glu Lys Ser Arg Glu Tyr Lys Asn Ser Asn Gln
                165                 170                 175     
Leu Arg Glu Tyr Gln Leu Glu Gly Met Asn Trp Leu Leu Phe Asn Trp
            180                 185                 190         
Tyr Asn Arg Lys Asn Cys Ile Leu Ala Asp Glu Met Gly Leu Gly Lys
        195                 200                 205             
Thr Ile Gln Ser Ile Thr Phe Leu Ser Glu Ile Phe Leu Arg Gly Ile
    210                 215                 220                 
His Gly Pro Phe Leu Ile Ile Ala Pro Leu Ser Thr Ile Thr Asn Trp
225                 230                 235                 240 
Glu Arg Glu Phe Arg Thr Trp Thr Glu Met Asn Ala Ile Val Tyr His
                245                 250                 255     
Gly Ser Gln Ile Ser Arg Gln Met Ile Gln Gln Tyr Glu Met Val Tyr
            260                 265                 270         
Arg Asp Ala Gln Gly Asn Pro Leu Ser Gly Val Phe Lys Phe His Val
        275                 280                 285             
Val Ile Thr Thr Phe Glu Met Ile Leu Ala Asp Cys Pro Glu Leu Lys
    290                 295                 300                 
Lys Ile His Trp Ser Cys Val Ile Ile Asp Glu Ala His Arg Leu Lys
305                 310                 315                 320 
Asn Arg Asn Cys Lys Leu Leu Glu Gly Leu Lys Leu Met Ala Leu Glu
                325                 330                 335     
His Lys Val Leu Leu Thr Gly Thr Pro Leu Gln Asn Ser Val Glu Glu
            340                 345                 350         
Leu Phe Ser Leu Leu Asn Phe Leu Glu Pro Ser Gln Phe Pro Ser Glu
        355                 360                 365             
Thr Ala Phe Leu Glu Glu Phe Gly Asp Leu Lys Thr Glu Glu Gln Val
    370                 375                 380                 
Lys Lys Leu Gln Ser Ile Leu Lys Pro Met Met Leu Arg Arg Leu Lys
385                 390                 395                 400 
Asp Asp Val Glu Lys Asn Leu Ala Pro Lys Gln Glu Thr Ile Ile Glu
                405                 410                 415     
Val Glu Leu Thr Asn Ile Gln Lys Lys Tyr Tyr Arg Ala Ile Leu Glu
            420                 425                 430         
Lys Asn Phe Ser Phe Leu Thr Lys Gly Ala Asn Gln His Asn Met Pro
        435                 440                 445             
Asn Leu Ile Asn Thr Met Met Glu Leu Arg Lys Cys Cys Asn His Pro
    450                 455                 460                 
Tyr Leu Ile Asn Gly Ala Glu Glu Lys Ile Leu Glu Asp Phe Arg Lys
465                 470                 475                 480 
Thr His Ser Pro Asp Ala Pro Asp Phe Gln Leu Gln Ala Met Ile Gln
                485                 490                 495     
Ala Ala Gly Lys Leu Val Leu Ile Asp Lys Leu Leu Pro Lys Leu Ile
            500                 505                 510         
Ala Gly Gly His Lys Val Leu Ile Phe Ser Gln Met Val Arg Cys Leu
        515                 520                 525             
Asp Ile Leu Glu Asp Tyr Leu Ile Gln Arg Arg Tyr Thr Tyr Glu Arg
    530                 535                 540                 
Ile Asp Gly Arg Val Arg Gly Asn Leu Arg Gln Ala Ala Ile Asp Arg
545                 550                 555                 560 
Phe Cys Lys Pro Asp Ser Asp Arg Phe Val Phe Leu Leu Cys Thr Arg
                565                 570                 575     
Ala Gly Gly Leu Gly Ile Asn Leu Thr Ala Ala Asp Thr Cys Ile Ile
            580                 585                 590         
Phe Asp Ser Asp Trp Asn Pro Gln Asn Asp Leu Gln Ala Gln Ala Arg
        595                 600                 605             
Cys His Arg Ile Gly Gln Ser Lys Ala Val Lys Val Tyr Arg Leu Ile
    610                 615                 620                 
Thr Arg Asn Ser Tyr Glu Arg Glu Met Phe Asp Lys Ala Ser Leu Lys
625                 630                 635                 640 
Leu Gly Leu Asp Lys Ala Val Leu Gln Asp Ile Asn Arg Lys Gly Gly
                645                 650                 655     
Thr Asn Gly Val Gln Gln Leu Ser Lys Met Glu Val Glu Asp Leu Leu
            660                 665                 670         
Arg Lys Gly Ala Tyr Gly Ala Leu Met Asp Glu Glu Asp Glu Gly Ser
        675                 680                 685             
Lys Phe Cys Glu Glu Asp Ile Asp Gln Ile Leu Gln Arg Arg Thr His
    690                 695                 700                 
Thr Ile Thr Ile Gln Ser Glu Gly Lys Gly Ser Thr Phe Ala Lys Ala
705                 710                 715                 720 
Ser Phe Val Ala Ser Gly Asn Arg Thr Asp Ile Ser Leu Asp Asp Pro
                725                 730                 735     
Asn Phe Trp Gln Lys Trp Ala Lys Ile Ala Glu Leu Asp Thr Glu Ala
            740                 745                 750         
Lys Asn Glu Lys Glu Ser Leu Val Ile Asp Arg Pro Arg Val Arg Lys
        755                 760                 765             
Gln Thr Lys His Tyr Asn Ser Phe Glu Glu Asp Glu Leu Met Glu Phe
    770                 775                 780                 
Ser Glu Leu Asp Ser Asp Ser Asp Glu Arg Pro Thr Arg Ser Arg Arg
785                 790                 795                 800 
Leu Asn Asp Lys Ala Arg Arg Tyr Leu Arg Ala Glu Cys Phe Arg Val
                805                 810                 815     
Glu Lys Asn Leu Leu Ile Phe Gly Trp Gly Arg Trp Lys Asp Ile Leu
            820                 825                 830         
Thr His Gly Arg Phe Lys Trp His Leu Asn Glu Lys Asp Met Glu Met
        835                 840                 845             
Ile Cys Arg Ala Leu Leu Val Tyr Cys Val Lys His Tyr Lys Gly Asp
    850                 855                 860                 
Glu Lys Ile Lys Ser Phe Ile Trp Glu Leu Ile Thr Pro Thr Lys Asp
865                 870                 875                 880 
Gly Gln Ala Gln Thr Leu Gln Asn His Ser Gly Leu Ser Ala Pro Val
                885                 890                 895     
Pro Arg Gly Arg Lys Gly Lys Lys Thr Lys Asn Gln Leu Leu Ile Pro
            900                 905                 910         
Glu Leu Lys Asp Ala Asp Trp Leu Ala Thr Cys Asn Pro Glu Val Val
        915                 920                 925             
Leu His Asp Asp Gly Tyr Lys Lys His Leu Lys Gln His Cys Asn Lys
    930                 935                 940                 
Val Leu Leu Arg Val Arg Met Leu Tyr Tyr Leu Lys Ala Glu Ile Leu
945                 950                 955                 960 
Gly Glu Ala Ala Glu Lys Ala Phe Glu Gly Ser Pro Ala Arg Glu Leu
                965                 970                 975     
Asp Val Pro Leu Pro Asp Ile Asp Tyr Met Glu Ile Pro Val Asp Trp
            980                 985                 990         
Trp Asp Ala Glu Ala Asp Lys Ser Leu Leu Ile Gly Val Phe Lys His
        995                 1000                1005            
Gly Tyr Glu Arg Tyr Asn Ala Met Arg Ala Asp Pro Ala Leu Cys Phe
    1010                1015                1020                
Leu Glu Lys Val Gly Met Pro Asp Glu Lys Ser Leu Ser Ala Glu Gln
1025                1030                1035                1040
Gly Val Thr Asp Gly Thr Ser Asp Ile Pro Glu Arg Gly Asn Thr Asp
                1045                1050                1055    
Lys Glu Asp Asn Ala Glu Asp Lys Val Asp Gly Leu Gln Lys Gln Thr
            1060                1065                1070        
Glu Ser Ser Ser Asp Gly Gly Asp Gly Val Phe Ser Glu Lys Lys Asp
        1075                1080                1085            
Asp Ser Arg Ala Ala Gln Asp Gly Ser Asp Pro Asp Lys Ser Pro Trp
    1090                1095                1100                
Pro Val Ser Ser Ala Leu Thr Ala Arg Leu Arg Arg Leu Val Thr Val
1105                1110                1115                1120
Tyr Gln Arg Cys Asn Arg Lys Glu Leu Cys Arg Pro Glu Ile Leu Gly
                1125                1130                1135    
Pro Gly Asn Gln Gly Tyr Trp Val Gln Glu Glu Met Phe Arg Arg Thr
            1140                1145                1150        
Ser Glu Met Asp Leu Ile Asn Lys Glu Ala Gln Lys Arg Trp Thr Arg
        1155                1160                1165            
Arg Glu Gln Ala Asp Phe Tyr Arg Thr Val Ser Ser Phe Gly Val Val
    1170                1175                1180                
Tyr Asp Gln Glu Lys Lys Thr Phe Asp Trp Thr Gln Phe Arg Ile Ile
1185                1190                1195                1200
Ser Arg Leu Asp Lys Lys Ser Asp Glu Ser Leu Glu Gln Tyr Phe Tyr
                1205                1210                1215    
Ser Phe Val Ala Met Cys Arg Asn Val Cys Arg Leu Pro Thr Trp Lys
            1220                1225                1230        
Asp Gly Gly Pro Pro Asp Thr Thr Ile Tyr Val Glu Pro Ile Thr Glu
        1235                1240                1245            
Glu Arg Ala Ala Arg Thr Leu Tyr Arg Ile Glu Leu Leu Arg Lys Val
    1250                1255                1260                
Arg Glu Gln Val Leu Lys Cys Pro Gln Leu His Glu Arg Leu Gln Leu
1265                1270                1275                1280
Cys Arg Pro Ser Leu Tyr Leu Pro Val Trp Trp Glu Cys Gly Lys His
                1285                1290                1295    
Asp Arg Asp Leu Leu Ile Gly Thr Ala Lys His Gly Leu Asn Arg Thr
            1300                1305                1310        
Asp Cys Tyr Ile Met Asn Asp Pro Gln Leu Ser Phe Leu Asp Ala Tyr
        1315                1320                1325            
Arg Asn Tyr Ala Gln His Lys Arg Ser Gly Thr Gln Ala Pro Gly Asn
    1330                1335                1340                
Leu Cys Cys Leu Tyr Gln Thr Asn Ser Lys Leu Tyr Glu Ser Leu Thr
1345                1350                1355                1360
Tyr Ser Gln Met Ser Arg Thr Ser Glu Ser Leu Glu Asn Glu Pro Glu
                1365                1370                1375    
Asn Leu Val Arg Val Glu Ser Arg Asp Asp His Leu Ser Leu Pro Asp
            1380                1385                1390        
Val Thr Cys Glu Asn Phe Ile Ser Lys Val Gln Asp Val Ile Ser Ile
        1395                1400                1405            
Asn His Asp Glu Ser Leu Leu Pro Glu Ser Leu Glu Ser Met Met Tyr
    1410                1415                1420                
Gly Lys Lys Val Leu Ser Gln Glu Pro Ser Ser Phe Gln Glu Ser Pro
1425                1430                1435                1440
Ser Thr Asn Thr Glu Ser Arg Lys Asp Val Ile Thr Ile Ser Ile Ser
                1445                1450                1455    
Lys Asp Gly Asn Cys Gln Ser Gly Gly Pro Glu Ala Glu Ile Ala Ser
            1460                1465                1470        
Gly Pro Thr Phe Met Gly Ser Leu Glu Ala Gly Gly Val Ala Gln Ala
        1475                1480                1485            
Asn Ile Lys Asn Gly Lys His Leu Leu Met Ser Ile Ser Lys Glu Gly
    1490                1495                1500                
Glu Leu Cys Cys Ser Glu Ala Gly Gln Arg Pro Glu Asn Ile Gly Gln
1505                1510                1515                1520
Leu Glu Ala Lys Cys Leu Ala Ser Pro Ser Leu Asn Pro Gly Asn Glu
                1525                1530                1535    
Ser Gly Phe Val Asp Met Cys Ser Leu Ser Val Cys Asp Ser Lys Arg
            1540                1545                1550        
Asn Leu Ser Ser Asp Gln Gln Leu Ile Asp Leu Leu Glu Asn Lys Ser
        1555                1560                1565            
Leu Glu Ser Lys Leu Ile Leu Ser Gln Asn His Ser Asp Glu Glu Glu
    1570                1575                1580                
Glu Glu Glu Glu Asn Glu Glu Glu Asn Leu Ala Met Ala Val Gly Met
1585                1590                1595                1600
Gly Glu Arg Pro Glu Val Leu His Leu Thr Glu Pro Thr Thr Asn Ile
                1605                1610                1615    
Ser Arg Glu Lys Asn Gln Gly Phe Gln Asp Glu Thr Lys Lys Gly Ser
            1620                1625                1630        
Leu Glu Val Ala Asn Gln Thr Pro Gly Leu Gln Arg Ala Phe Pro Ala
        1635                1640                1645            
Pro Ala Ala Cys Gln Cys His Cys Lys His Met Glu Arg Trp Met His
    1650                1655                1660                
Gly Leu Glu Asn Asp Glu Phe Glu Ile Glu Lys Pro Lys Ala Tyr Ile
1665                1670                1675                1680
Pro Asp Leu Phe Lys Ser Lys Thr Asn Thr Ile Ala Met Glu Gly Glu
                1685                1690                1695    
Pro Thr Ala Ile Pro Ser Gln Pro Phe Lys Val Lys His Glu Leu Leu
            1700                1705                1710        
Lys Glu Pro Trp Lys Glu Ser Ala Glu Gly Gln Asn Val Phe Pro Thr
        1715                1720                1725            
Tyr Pro Leu Glu Gly Ser Glu Leu Lys Ser Glu Asp Met Asp Phe Glu
    1730                1735                1740                
Asn Lys Asp Asp Tyr Asp Arg Asp Gly Asn Cys His Ser Gln Asp Tyr
1745                1750                1755                1760
Pro Gly Lys Tyr Ser Glu Glu Glu Ser Lys Ser Ser Thr Ser Gly Ile
                1765                1770                1775    
Thr Gly Asp Ile Gly Asp Glu Leu Gln Glu Ala Arg Ala Pro Thr Ile
            1780                1785                1790        
Ala Gln Leu Leu Gln Glu Lys Thr Leu Tyr Ser Phe Ser Glu Trp Pro
        1795                1800                1805            
Lys Asp Arg Val Ile Ile Asn Arg Leu Asp Asn Ile Cys His Val Val
    1810                1815                1820                
Leu Lys Gly Lys Trp Pro Ser Ser Gln Gln Tyr Glu Pro Ser Gly Thr
1825                1830                1835                1840
Leu Pro Thr Pro Val Leu Thr Ser Ser Ala Gly Ser Arg Thr Ser Leu
                1845                1850                1855    
Ser Glu Pro Glu Ala Ala Glu His Ser Phe Ser Asn Gly Ala Ala Leu
            1860                1865                1870        
Ala Ala Gln Ile His Lys Glu Ser Phe Leu Ala Pro Val Phe Thr Lys
        1875                1880                1885            
Asp Glu Gln Lys His Arg Arg Pro Tyr Glu Phe Glu Val Glu Arg Asp
    1890                1895                1900                
Ala Lys Ala Arg Gly Leu Glu Gln Phe Ser Ala Thr His Gly His Thr
1905                1910                1915                1920
Pro Ile Ile Leu Asn Gly Trp His Gly Glu Ser Ala Met Asp Leu Ser
                1925                1930                1935    
Cys Ser Ser Glu Gly Ser Pro Gly Ala Thr Ser Pro Phe Pro Val Ser
            1940                1945                1950        
Ala Ser Thr Pro Lys Ile Gly Ala Ile Ser Ser Leu Gln Gly Ala Leu
        1955                1960                1965            
Gly Met Asp Leu Ser Gly Ile Leu Gln Ala Gly Leu Ile His Pro Val
    1970                1975                1980                
Thr Gly Gln Ile Val Asn Gly Ser Leu Arg Arg Asp Asp Ala Ala Thr
1985                1990                1995                2000
Arg Arg Arg Arg Gly Arg Arg Lys His Val Glu Gly Gly Met Asp Leu
                2005                2010                2015    
Ile Phe Leu Lys Glu Gln Thr Leu Gln Ala Gly Ile Leu Glu Val His
            2020                2025                2030        
Glu Asp Pro Gly Gln Ala Thr Leu Ser Thr Thr His Pro Glu Gly Pro
        2035                2040                2045            
Gly Pro Ala Thr Ser Ala Pro Glu Pro Ala Thr Ala Ala Ser Ser Gln
    2050                2055                2060                
Ala Glu Lys Ser Ile Pro Ser Lys Ser Leu Leu Asp Trp Leu Arg Gln
2065                2070                2075                2080
Gln Ala Asp Tyr Ser Leu Glu Val Pro Gly Phe Gly Ala Asn Phe Ser
                2085                2090                2095    
Asp Lys Pro Lys Gln Arg Arg Pro Arg Cys Lys Glu Pro Gly Lys Leu
            2100                2105                2110        
Asp Val Ser Ser Leu Thr Gly Lys Arg Glu Phe Leu Pro Ser Pro Arg
        2115                2120                2125            
Ser Gln Asp
    2130    


<210> 1180
<211> 562
<212> PRT
<213> Homo sapiens

<400> 1180
Gly Thr Arg Lys Asn Gly Arg Asn Arg Gly Gly Lys Ala Asn Asn Pro
 1               5                  10                  15      
Pro Tyr Leu Pro Pro Glu Ala Glu Asp Gly Asn Ile Glu Tyr Lys Leu
            20                  25                  30          
Lys Leu Val Asn Pro Ser Gln Tyr Arg Phe Glu His Leu Val Thr Gln
        35                  40                  45              
Met Lys Trp Arg Leu Gln Glu Gly Arg Gly Glu Ala Val Tyr Gln Ile
    50                  55                  60                  
Gly Val Glu Asp Asn Gly Leu Leu Val Gly Leu Ala Glu Glu Glu Met
65                  70                  75                  80  
Arg Ala Ser Leu Lys Thr Leu His Arg Met Ala Glu Lys Val Gly Ala
                85                  90                  95      
Asp Ile Thr Val Leu Arg Glu Arg Glu Val Asp Tyr Asp Ser Asp Met
            100                 105                 110         
Pro Arg Lys Ile Thr Glu Val Leu Val Arg Lys Val Pro Asp Asn Gln
        115                 120                 125             
Gln Phe Leu Asp Leu Arg Val Ala Val Leu Gly Asn Val Asp Ser Gly
    130                 135                 140                 
Lys Ser Thr Leu Leu Gly Val Leu Thr Gln Gly Glu Leu Asp Asn Gly
145                 150                 155                 160 
Arg Gly Arg Ala Arg Leu Asn Leu Phe Arg His Leu His Glu Ile Gln
                165                 170                 175     
Ser Gly Arg Thr Ser Ser Ile Ser Phe Glu Ile Leu Gly Phe Asn Ser
            180                 185                 190         
Lys Gly Glu Val Val Asn Tyr Ser Asp Ser Arg Thr Ala Glu Glu Ile
        195                 200                 205             
Cys Glu Ser Ser Ser Lys Met Ile Thr Phe Ile Asp Leu Ala Gly His
    210                 215                 220                 
His Lys Tyr Leu His Thr Thr Ile Phe Gly Leu Thr Ser Tyr Cys Pro
225                 230                 235                 240 
Asp Cys Ala Leu Leu Leu Val Ser Ala Asn Thr Gly Ile Ala Gly Thr
                245                 250                 255     
Thr Arg Glu His Leu Gly Leu Ala Leu Ala Leu Lys Val Pro Phe Phe
            260                 265                 270         
Ile Val Val Ser Lys Ile Asp Leu Cys Ala Lys Thr Thr Val Glu Arg
        275                 280                 285             
Thr Val Arg Gln Leu Glu Arg Val Leu Lys Gln Pro Gly Cys His Lys
    290                 295                 300                 
Val Pro Met Leu Val Thr Ser Glu Asp Asp Ala Val Thr Ala Ala Gln
305                 310                 315                 320 
Gln Phe Ala Gln Ser Pro Asn Val Thr Pro Ile Phe Thr Leu Ser Ser
                325                 330                 335     
Val Ser Gly Glu Ser Leu Asp Leu Leu Lys Val Phe Leu Asn Ile Leu
            340                 345                 350         
Pro Pro Leu Thr Asn Ser Lys Glu Gln Glu Glu Leu Met Gln Gln Leu
        355                 360                 365             
Thr Glu Phe Gln Val Asp Glu Ile Tyr Thr Val Pro Glu Val Gly Thr
    370                 375                 380                 
Val Val Gly Gly Thr Leu Ser Ser Gly Ile Cys Arg Glu Gly Asp Gln
385                 390                 395                 400 
Leu Val Val Gly Pro Thr Asp Asp Gly Cys Phe Leu Glu Leu Arg Val
                405                 410                 415     
Cys Ser Ile Gln Arg Asn Arg Ser Ala Cys Arg Val Leu Arg Ala Gly
            420                 425                 430         
Gln Ala Ala Thr Leu Ala Leu Gly Asp Phe Asp Arg Ala Leu Leu Arg
        435                 440                 445             
Lys Gly Met Val Met Val Ser Pro Glu Met Asn Pro Thr Ile Cys Ser
    450                 455                 460                 
Val Phe Glu Ala Glu Ile Val Leu Leu Phe His Ala Thr Thr Phe Arg
465                 470                 475                 480 
Arg Gly Phe Gln Val Thr Val His Val Gly Asn Val Arg Gln Thr Ala
                485                 490                 495     
Val Val Glu Lys Ile His Ala Lys Asp Lys Leu Arg Thr Gly Glu Lys
            500                 505                 510         
Ala Val Val Arg Phe Arg Phe Leu Lys His Pro Glu Tyr Leu Lys Val
        515                 520                 525             
Gly Ala Lys Leu Leu Phe Arg Glu Gly Val Thr Lys Gly Ile Gly His
    530                 535                 540                 
Val Thr Asp Val Gln Ala Ile Thr Ala Gly Glu Ala Gln Ala Asn Met
545                 550                 555                 560 
Gly Phe
        


<210> 1181
<211> 1027
<212> PRT
<213> Homo sapiens

<400> 1181
Phe Phe Ser Phe Ile Glu Gly Cys Leu Val Lys Asn Tyr Met Gln Arg
 1               5                  10                  15      
Pro Ser Thr Glu Gln Leu Leu Lys His Pro Phe Ile Arg Asp Gln Pro
            20                  25                  30          
Asn Glu Arg Gln Val Arg Ile Gln Leu Lys Asp His Ile Asp Arg Thr
        35                  40                  45              
Arg Lys Lys Arg Gly Glu Lys Asp Glu Thr Glu Tyr Glu Tyr Ser Gly
    50                  55                  60                  
Ser Glu Glu Glu Glu Glu Glu Val Pro Glu Gln Glu Gly Glu Pro Ser
65                  70                  75                  80  
Ser Ile Val Asn Val Pro Gly Glu Ser Thr Leu Arg Arg Asp Phe Leu
                85                  90                  95      
Arg Leu Gln Gln Glu Asn Lys Glu Arg Ser Glu Ala Leu Arg Arg Gln
            100                 105                 110         
Gln Leu Leu Gln Glu Gln Gln Leu Arg Glu Gln Glu Glu Tyr Lys Arg
        115                 120                 125             
Gln Leu Leu Ala Glu Arg Gln Lys Arg Ile Glu Gln Gln Lys Glu Gln
    130                 135                 140                 
Arg Arg Arg Leu Glu Glu Gln Gln Arg Arg Glu Arg Glu Ala Arg Arg
145                 150                 155                 160 
Gln Gln Glu Arg Glu Gln Arg Arg Arg Glu Gln Glu Glu Lys Arg Arg
                165                 170                 175     
Leu Glu Glu Leu Glu Arg Arg Arg Lys Glu Glu Glu Glu Arg Arg Arg
            180                 185                 190         
Ala Glu Glu Glu Lys Arg Arg Val Glu Arg Glu Gln Glu Tyr Ile Arg
        195                 200                 205             
Arg Gln Leu Glu Glu Glu Gln Arg His Leu Glu Val Leu Gln Gln Gln
    210                 215                 220                 
Leu Leu Gln Glu Gln Ala Met Leu Leu Glu Cys Arg Trp Arg Glu Met
225                 230                 235                 240 
Glu Glu His Arg Gln Ala Glu Arg Leu Gln Arg Gln Leu Gln Gln Glu
                245                 250                 255     
Gln Ala Tyr Leu Leu Ser Leu Gln His Asp His Arg Arg Pro His Pro
            260                 265                 270         
Gln His Ser Gln Gln Pro Pro Pro Pro Gln Gln Glu Arg Ser Lys Pro
        275                 280                 285             
Ser Phe His Ala Pro Glu Pro Lys Ala His Tyr Glu Pro Ala Asp Arg
    290                 295                 300                 
Ala Arg Glu Val Glu Asp Arg Phe Arg Lys Thr Asn His Ser Ser Pro
305                 310                 315                 320 
Glu Ala Gln Ser Lys Gln Thr Gly Arg Val Leu Glu Pro Pro Val Pro
                325                 330                 335     
Ser Arg Ser Glu Ser Phe Ser Asn Gly Asn Ser Glu Ser Val His Pro
            340                 345                 350         
Ala Leu Gln Arg Pro Ala Glu Pro Gln Val Gln Trp Ser His Leu Ala
        355                 360                 365             
Ser Leu Lys Asn Asn Val Ser Pro Val Ser Arg Ser His Ser Phe Ser
    370                 375                 380                 
Asp Pro Ser Pro Lys Phe Ala His His His Leu Arg Ser Gln Asp Pro
385                 390                 395                 400 
Cys Pro Pro Ser Arg Ser Glu Val Leu Ser Gln Ser Ser Asp Ser Lys
                405                 410                 415     
Ser Glu Ala Pro Asp Pro Thr Gln Lys Ala Trp Ser Arg Ser Asp Ser
            420                 425                 430         
Asp Glu Val Pro Pro Arg Val Pro Val Arg Thr Thr Ser Arg Ser Pro
        435                 440                 445             
Val Leu Ser Arg Arg Asp Ser Pro Leu Gln Gly Ser Gly Gln Gln Asn
    450                 455                 460                 
Ser Gln Ala Gly Gln Arg Asn Ser Thr Ser Ser Ile Glu Pro Arg Leu
465                 470                 475                 480 
Leu Trp Glu Arg Val Glu Lys Leu Val Pro Arg Pro Gly Ser Gly Ser
                485                 490                 495     
Ser Ser Gly Ser Ser Asn Ser Gly Ser Gln Pro Gly Ser His Pro Gly
            500                 505                 510         
Ser Gln Ser Gly Ser Gly Glu Arg Phe Arg Val Arg Ser Ser Ser Lys
        515                 520                 525             
Ser Glu Gly Ser Pro Ser Gln Arg Leu Glu Asn Ala Val Lys Lys Pro
    530                 535                 540                 
Glu Asp Lys Lys Glu Val Phe Arg Pro Leu Lys Pro Ala Gly Glu Val
545                 550                 555                 560 
Asp Leu Thr Ala Leu Ala Lys Glu Leu Arg Ala Val Glu Asp Val Arg
                565                 570                 575     
Pro Pro His Lys Val Thr Asp Tyr Ser Ser Ser Ser Glu Glu Ser Gly
            580                 585                 590         
Thr Thr Asp Glu Glu Asp Asp Asp Val Glu Gln Glu Gly Ala Asp Glu
        595                 600                 605             
Ser Thr Ser Gly Pro Glu Asp Thr Arg Ala Ala Ser Ser Leu Asn Leu
    610                 615                 620                 
Ser Asn Gly Glu Thr Glu Ser Val Lys Thr Met Ile Val His Asp Asp
625                 630                 635                 640 
Val Glu Ser Glu Pro Ala Met Thr Pro Ser Lys Glu Gly Thr Leu Ile
                645                 650                 655     
Val Arg Gln Thr Gln Ser Ala Ser Ser Thr Leu Gln Lys His Lys Ser
            660                 665                 670         
Ser Ser Ser Phe Thr Pro Phe Ile Asp Pro Arg Leu Leu Gln Ile Ser
        675                 680                 685             
Pro Ser Ser Gly Thr Thr Val Thr Ser Val Val Gly Phe Ser Cys Asp
    690                 695                 700                 
Gly Met Arg Pro Glu Ala Ile Arg Gln Asp Pro Thr Arg Lys Gly Ser
705                 710                 715                 720 
Val Val Asn Val Asn Pro Thr Asn Thr Arg Pro Gln Ser Asp Thr Pro
                725                 730                 735     
Glu Ile Arg Lys Tyr Lys Lys Arg Phe Asn Ser Glu Ile Leu Cys Ala
            740                 745                 750         
Ala Leu Trp Gly Val Asn Leu Leu Val Gly Thr Glu Ser Gly Leu Met
        755                 760                 765             
Leu Leu Asp Arg Ser Gly Gln Gly Lys Val Tyr Pro Leu Ile Asn Arg
    770                 775                 780                 
Arg Arg Phe Gln Gln Met Asp Val Leu Glu Gly Leu Asn Val Leu Val
785                 790                 795                 800 
Thr Ile Ser Gly Lys Lys Asp Lys Leu Arg Val Tyr Tyr Leu Ser Trp
                805                 810                 815     
Leu Arg Asn Lys Ile Leu His Asn Asp Pro Glu Val Glu Lys Lys Gln
            820                 825                 830         
Gly Trp Thr Thr Val Gly Asp Leu Glu Gly Cys Val His Tyr Lys Val
        835                 840                 845             
Val Lys Tyr Glu Arg Ile Lys Phe Leu Val Ile Ala Leu Lys Ser Ser
    850                 855                 860                 
Val Glu Val Tyr Ala Trp Ala Pro Lys Pro Tyr His Lys Phe Met Ala
865                 870                 875                 880 
Phe Lys Ser Phe Gly Glu Leu Val His Lys Pro Leu Leu Val Asp Leu
                885                 890                 895     
Thr Val Glu Glu Gly Gln Arg Leu Lys Val Ile Tyr Gly Ser Cys Ala
            900                 905                 910         
Gly Phe His Ala Val Asp Val Asp Ser Gly Ser Val Tyr Asp Ile Tyr
        915                 920                 925             
Leu Pro Thr His Ile Gln Cys Ser Ile Lys Pro His Ala Ile Ile Ile
    930                 935                 940                 
Leu Pro Asn Thr Asp Gly Met Glu Leu Leu Val Cys Tyr Glu Asp Glu
945                 950                 955                 960 
Gly Val Tyr Val Asn Thr Tyr Gly Arg Ile His Gln Gly Cys Ser Ser
                965                 970                 975     
Thr Val Gly Arg Asp Ala Tyr Ile Ser Ser Ile Tyr Ser Ile Gln Ser
            980                 985                 990         
Asp Asn Gly Leu Gly Arg Glu Gly His Arg Asp Pro Ile Cys Gly Asn
        995                 1000                1005            
Trp Ser Leu Gly Trp Cys Val His Ala Gln Lys Gly Ser Lys Thr Lys
    1010                1015                1020                
Ile Leu Val
1025        


<210> 1182
<211> 254
<212> PRT
<213> Homo sapiens

<400> 1182
Met Arg His Thr Trp Pro Phe Arg Asn Val Pro Phe Gly Cys Cys Thr
 1               5                  10                  15      
Pro Ile His Pro Val Tyr Thr Ser Ser Arg Gly Asp His Leu Gly Cys
            20                  25                  30          
Trp Ala Leu Arg Pro Glu Cys Leu Arg Ile Val Ser Arg Ala Pro Trp
        35                  40                  45              
Thr Ser Thr Ser Val Gly Phe Val Ala Val Gly Pro Gln Cys Leu Pro
    50                  55                  60                  
Val Arg Gly Trp His Ser Ser Arg Pro Val Arg Asp Asp Ser Val Val
65                  70                  75                  80  
Glu Lys Ser Leu Lys Ser Leu Lys Asp Lys Asn Lys Lys Leu Glu Glu
                85                  90                  95      
Gly Gly Pro Val Tyr Ser Pro Pro Ala Glu Val Val Val Lys Lys Ser
            100                 105                 110         
Leu Gly Gln Arg Val Leu Asp Glu Leu Lys His Tyr Tyr His Gly Phe
        115                 120                 125             
Arg Leu Leu Trp Ile Asp Thr Lys Ile Ala Ala Arg Met Leu Trp Arg
    130                 135                 140                 
Ile Leu Asn Gly His Ser Leu Thr Arg Arg Glu Arg Arg Gln Phe Leu
145                 150                 155                 160 
Arg Ile Cys Ala Asp Leu Phe Arg Leu Val Pro Phe Leu Val Phe Val
                165                 170                 175     
Val Val Pro Phe Met Glu Phe Leu Leu Pro Val Ala Val Lys Leu Phe
            180                 185                 190         
Pro Asn Met Leu Pro Ser Thr Phe Glu Thr Gln Ser Leu Lys Glu Glu
        195                 200                 205             
Arg Leu Lys Lys Glu Leu Arg Val Lys Leu Glu Leu Ala Lys Phe Leu
    210                 215                 220                 
Gln Asp Thr Ile Glu Glu Met Ala Leu Lys Asn Lys Ala Ala Lys Gly
225                 230                 235                 240 
Ser Ala Thr Lys Asp Phe Ser Val Phe Phe Gln Lys Val Leu
                245                 250                 


<210> 1183
<211> 308
<212> PRT
<213> Homo sapiens

<400> 1183
Glu Thr Phe Ser Ser Val Ile Ser Leu Leu Asn Glu Asp Pro Leu Ser
 1               5                  10                  15      
Gln Asp Leu Pro Val Lys Met Ala Ser Ile Phe Lys Asn Phe Val Ile
            20                  25                  30          
Thr Tyr Asn Arg Thr Tyr Glu Ser Lys Glu Glu Ala Arg Trp Arg Leu
        35                  40                  45              
Ser Val Phe Val Asn Asn Met Val Arg Ala Gln Lys Ile Gln Ala Leu
    50                  55                  60                  
Asp Arg Gly Thr Ala Gln Tyr Gly Val Thr Lys Phe Ser Asp Leu Thr
65                  70                  75                  80  
Glu Glu Glu Phe Arg Thr Ile Tyr Leu Asn Thr Leu Leu Arg Lys Glu
                85                  90                  95      
Pro Gly Asn Lys Met Lys Gln Ala Lys Ser Val Gly Asp Leu Ala Pro
            100                 105                 110         
Pro Glu Trp Asp Trp Arg Ser Lys Gly Ala Val Thr Lys Val Lys Asp
        115                 120                 125             
Gln Gly Met Cys Gly Ser Cys Trp Ala Phe Ser Val Thr Gly Asn Val
    130                 135                 140                 
Glu Gly Gln Trp Phe Leu Asn Gln Gly Thr Leu Leu Ser Leu Ser Glu
145                 150                 155                 160 
Gln Glu Leu Leu Asp Cys Asp Lys Met Asp Lys Ala Cys Met Gly Gly
                165                 170                 175     
Leu Pro Ser Asn Ala Tyr Ser Ala Ile Lys Asn Leu Gly Gly Leu Glu
            180                 185                 190         
Thr Glu Asp Asp Tyr Ser Tyr Gln Gly His Met Gln Ser Cys Asn Phe
        195                 200                 205             
Ser Ala Glu Lys Ala Lys Val Tyr Ile Asn Asp Ser Val Glu Leu Ser
    210                 215                 220                 
Gln Asn Glu Gln Lys Leu Ala Ala Trp Leu Ala Lys Arg Gly Pro Ile
225                 230                 235                 240 
Ser Val Ala Ile Asn Ala Phe Gly Met Gln Phe Tyr Arg His Gly Ile
                245                 250                 255     
Ser Arg Pro Leu Arg Pro Leu Cys Ser Pro Trp Leu Ile Asp His Ala
            260                 265                 270         
Val Leu Leu Val Gly Tyr Gly Asn Arg Glu Phe Arg Cys Leu Ser Cys
        275                 280                 285             
Ile Gln Pro Gly His Arg Gln Gly Trp Asp His Ser Ile Ser Gly Pro
    290                 295                 300                 
Leu Glu Gly Lys
305             


<210> 1184
<211> 315
<212> PRT
<213> Homo sapiens

<400> 1184
Thr Pro Asp Glu Pro Met Asp Leu Glu Gly Ala Glu Asp Asn His Leu
 1               5                  10                  15      
Ser Leu Leu Glu Ala Pro Gly Gly Gln Pro Arg Lys Ser Leu Arg His
            20                  25                  30          
Ser Thr Arg Lys Lys Glu Trp Gly Lys Lys Glu Pro Val Ala Gly Ser
        35                  40                  45              
Pro Phe Glu Arg Arg Glu Ala Gly Pro Lys Gly Pro Cys Pro Gly Glu
    50                  55                  60                  
Glu Gly Glu Gly Val Gly Asp Arg Val Pro Asn Gly Ile Leu Ala Ser
65                  70                  75                  80  
Gly Ala Gly Pro Ser Gly Pro Tyr Gly Glu Pro Pro Tyr Pro Cys Lys
                85                  90                  95      
Glu Glu Glu Glu Asn Gly Lys Asp Ala Ser Glu Asp Ser Ala Gln Ser
            100                 105                 110         
Gly Ser Glu Gly Gly Ser Gly His Ala Ser Ala His Tyr Met Tyr Arg
        115                 120                 125             
Gln Glu Gly Tyr Glu Thr Val Ser Tyr Gly Asp Asn Leu Tyr Val Cys
    130                 135                 140                 
Ile Pro Cys Ala Lys Gly Phe Pro Ser Ser Glu Gln Leu Asn Ala His
145                 150                 155                 160 
Val Glu Thr His Thr Glu Glu Glu Leu Phe Ile Lys Glu Glu Gly Ala
                165                 170                 175     
Tyr Glu Thr Gly Ser Gly Gly Ala Glu Glu Glu Ala Glu Asp Leu Ser
            180                 185                 190         
Ala Pro Ser Ala Ala Tyr Thr Ala Glu Pro Arg Pro Phe Lys Cys Ser
        195                 200                 205             
Val Cys Glu Lys Thr Tyr Lys Asp Pro Ala Thr Leu Arg Gln His Glu
    210                 215                 220                 
Lys Thr His Trp Leu Thr Arg Pro Phe Pro Cys Asn Ile Cys Gly Lys
225                 230                 235                 240 
Met Phe Thr Gln Arg Gly Thr Met Thr Arg His Met Arg Ser His Leu
                245                 250                 255     
Gly Leu Lys Pro Phe Ala Cys Asp Glu Cys Gly Met Arg Phe Thr Arg
            260                 265                 270         
Gln Tyr Arg Leu Thr Glu His Met Arg Val His Ser Gly Glu Lys Pro
        275                 280                 285             
Tyr Glu Cys Gln Leu Cys Gly Gly Lys Phe Thr Gln Gln Arg Asn Leu
    290                 295                 300                 
Ile Ser His Leu Arg Met His Thr Ser Pro Ser
305                 310                 315 


<210> 1185
<211> 303
<212> PRT
<213> Homo sapiens

<400> 1185
Val Thr Tyr Leu Glu Asp Tyr Ser Ala Glu Tyr Ile Ile Gln Gln Gly
 1               5                  10                  15      
Gly Trp Gly Thr Val Phe Ser Leu Glu Ser Glu Glu Glu Glu Tyr Pro
            20                  25                  30          
Gly Ile Thr Ala Glu Asp Ser Asn Asp Ile Tyr Ile Leu Pro Ser Asp
        35                  40                  45              
Asn Ser Gly Gln Val Ser Pro Pro Glu Ser Pro Thr Val Thr Thr Ser
    50                  55                  60                  
Trp Gln Ser Glu Ser Leu Pro Val Ser Leu Ser Ala Ser Gln Ser Trp
65                  70                  75                  80  
His Thr Glu Ser Leu Pro Val Ser Leu Gly Pro Glu Ser Trp Gln Gln
                85                  90                  95      
Ile Ala Met Asp Pro Glu Glu Val Lys Ser Leu Asp Ser Asn Gly Ala
            100                 105                 110         
Gly Glu Lys Ser Glu Asn Asn Ser Ser Asn Ser Asp Ile Val His Val
        115                 120                 125             
Glu Lys Glu Glu Val Pro Glu Gly Met Glu Glu Ala Ala Val Ala Ser
    130                 135                 140                 
Val Val Leu Pro Ala Arg Glu Leu Gln Glu Ala Leu Pro Glu Ala Pro
145                 150                 155                 160 
Ala Pro Leu Leu Pro His Ile Thr Ala Thr Ser Leu Leu Gly Thr Arg
                165                 170                 175     
Glu Pro Asp Thr Glu Val Ile Thr Val Glu Lys Ser Ser Pro Ala Thr
            180                 185                 190         
Ser Leu Phe Val Glu Leu Asp Glu Glu Glu Val Lys Ala Ala Thr Thr
        195                 200                 205             
Gln Pro Thr Glu Val Glu Glu Val Val Pro Ala Leu Glu Pro Thr Glu
    210                 215                 220                 
Thr Leu Leu Ser Glu Lys Glu Ile Asn Ala Arg Glu Glu Ser Leu Val
225                 230                 235                 240 
Glu Glu Leu Ser Pro Ala Ser Glu Lys Lys Pro Val Pro Pro Ser Glu
                245                 250                 255     
Gly Lys Ser Arg Leu Ser Pro Ala Gly Glu Met Lys Pro Met Pro Leu
            260                 265                 270         
Ser Glu Gly Lys Ser Ile Leu Leu Phe Gly Gly Ala Ala Ala Val Ala
        275                 280                 285             
Ile Leu Ala Val Ala Ile Gly Val Ala Leu Ala Leu Arg Lys Lys
    290                 295                 300             


<210> 1186
<211> 303
<212> PRT
<213> Homo sapiens

<400> 1186
Val Thr Tyr Leu Glu Asp Tyr Ser Ala Glu Tyr Ile Ile Gln Gln Gly
 1               5                  10                  15      
Gly Trp Gly Thr Val Phe Ser Leu Glu Ser Glu Glu Glu Glu Tyr Pro
            20                  25                  30          
Gly Ile Thr Ala Glu Asp Ser Asn Asp Ile Tyr Ile Leu Pro Ser Asp
        35                  40                  45              
Asn Ser Gly Gln Val Ser Pro Pro Glu Ser Pro Thr Val Thr Thr Ser
    50                  55                  60                  
Trp Gln Ser Glu Ser Leu Pro Val Ser Leu Ser Ala Ser Gln Ser Trp
65                  70                  75                  80  
His Thr Glu Ser Leu Pro Val Ser Leu Gly Pro Glu Ser Trp Gln Gln
                85                  90                  95      
Ile Ala Met Asp Pro Glu Glu Val Lys Ser Leu Asp Ser Asn Gly Ala
            100                 105                 110         
Gly Glu Lys Ser Glu Asn Asn Ser Ser Asn Ser Asp Ile Val His Val
        115                 120                 125             
Glu Lys Glu Glu Val Pro Glu Gly Met Glu Glu Ala Ala Val Ala Ser
    130                 135                 140                 
Val Val Leu Pro Ala Arg Glu Leu Gln Glu Ala Leu Pro Glu Ala Pro
145                 150                 155                 160 
Ala Pro Leu Leu Pro His Ile Thr Ala Thr Ser Leu Leu Gly Thr Arg
                165                 170                 175     
Glu Pro Asp Thr Glu Val Ile Thr Val Glu Lys Ser Ser Pro Ala Thr
            180                 185                 190         
Ser Leu Phe Val Glu Leu Asp Glu Glu Glu Val Lys Ala Ala Thr Thr
        195                 200                 205             
Gln Pro Thr Glu Val Glu Glu Val Val Pro Ala Leu Glu Pro Thr Glu
    210                 215                 220                 
Thr Leu Leu Ser Glu Lys Glu Ile Asn Ala Arg Glu Glu Ser Leu Val
225                 230                 235                 240 
Glu Glu Leu Ser Pro Ala Ser Glu Lys Lys Pro Val Pro Pro Ser Glu
                245                 250                 255     
Gly Lys Ser Arg Leu Ser Pro Ala Gly Glu Met Lys Pro Met Pro Leu
            260                 265                 270         
Ser Glu Gly Lys Ser Ile Leu Leu Phe Gly Gly Ala Ala Ala Val Ala
        275                 280                 285             
Ile Leu Ala Val Ala Ile Gly Val Ala Leu Ala Leu Arg Lys Lys
    290                 295                 300             


<210> 1187
<211> 741
<212> PRT
<213> Homo sapiens

<400> 1187
Ser Trp Gly Ser Val Leu Ala Ser His Glu Arg Ser Pro Arg Arg Ala
 1               5                  10                  15      
Ala Ala Leu Gly Glu Ala Lys Arg Pro Thr Arg Lys Thr Leu Glu His
            20                  25                  30          
Asn Cys Ala His Phe Cys Ile Asn Ile Pro Gly Ser Tyr Val Cys Arg
        35                  40                  45              
Cys Lys Gln Gly Tyr Ile Leu Asn Ser Asp Gln Thr Thr Cys Arg Ile
    50                  55                  60                  
Gln Asp Leu Cys Ala Met Glu Asp His Asn Cys Glu Gln Leu Cys Val
65                  70                  75                  80  
Asn Val Pro Gly Ser Phe Val Cys Gln Cys Tyr Ser Gly Tyr Ala Leu
                85                  90                  95      
Ala Glu Asp Gly Lys Arg Cys Val Ala Val Asp Tyr Cys Ala Ser Glu
            100                 105                 110         
Asn His Gly Cys Glu His Glu Cys Val Asn Ala Asp Gly Ser Tyr Leu
        115                 120                 125             
Cys Gln Cys His Glu Gly Phe Ala Leu Asn Pro Asp Glu Lys Thr Cys
    130                 135                 140                 
Thr Lys Ile Asp Tyr Cys Ala Ser Ser Asn His Gly Cys Gln His Glu
145                 150                 155                 160 
Cys Val Asn Thr Asp Asp Ser Tyr Ser Cys His Cys Leu Lys Gly Phe
                165                 170                 175     
Thr Leu Asn Pro Asp Lys Lys Thr Cys Arg Arg Ile Asn Tyr Cys Ala
            180                 185                 190         
Leu Asn Lys Pro Gly Cys Glu His Glu Cys Val Asn Met Glu Glu Ser
        195                 200                 205             
Tyr Tyr Cys Arg Cys His Arg Gly Tyr Thr Leu Asp Pro Asn Gly Lys
    210                 215                 220                 
Thr Cys Ser Arg Val Asp His Cys Ala Gln Gln Asp His Gly Cys Glu
225                 230                 235                 240 
Gln Leu Cys Leu Asn Thr Glu Asp Ser Phe Val Cys Gln Cys Ser Glu
                245                 250                 255     
Gly Phe Leu Ile Asn Glu Asp Leu Lys Thr Cys Ser Arg Val Asp Tyr
            260                 265                 270         
Cys Leu Leu Ser Asp His Gly Cys Glu Tyr Ser Cys Val Asn Met Asp
        275                 280                 285             
Arg Ser Phe Ala Cys Gln Cys Pro Glu Gly His Val Leu Arg Ser Asp
    290                 295                 300                 
Gly Lys Thr Cys Ala Lys Leu Asp Ser Cys Ala Leu Gly Asp His Gly
305                 310                 315                 320 
Cys Glu His Ser Cys Val Ser Ser Glu Asp Ser Phe Val Cys Gln Cys
                325                 330                 335     
Phe Glu Gly Tyr Ile Leu Arg Glu Asp Gly Lys Thr Cys Arg Arg Lys
            340                 345                 350         
Asp Val Cys Gln Ala Ile Asp His Gly Cys Glu His Ile Cys Val Asn
        355                 360                 365             
Ser Asp Asp Ser Tyr Thr Cys Glu Cys Leu Glu Gly Phe Arg Leu Ala
    370                 375                 380                 
Glu Asp Gly Lys Arg Cys Arg Arg Lys Asp Val Cys Lys Ser Thr His
385                 390                 395                 400 
His Gly Cys Glu His Ile Cys Val Asn Asn Gly Asn Ser Tyr Ile Cys
                405                 410                 415     
Lys Cys Ser Glu Gly Phe Val Leu Ala Glu Asp Gly Arg Arg Cys Lys
            420                 425                 430         
Lys Cys Thr Glu Gly Pro Ile Asp Leu Val Phe Val Ile Asp Gly Ser
        435                 440                 445             
Lys Ser Leu Gly Glu Glu Asn Phe Glu Val Val Lys Gln Phe Val Thr
    450                 455                 460                 
Gly Ile Ile Asp Ser Leu Thr Ile Ser Pro Lys Ala Ala Arg Val Gly
465                 470                 475                 480 
Leu Leu Gln Tyr Ser Thr Gln Val His Thr Glu Phe Thr Leu Arg Asn
                485                 490                 495     
Phe Asn Ser Ala Lys Asp Met Lys Lys Ala Val Ala His Met Lys Tyr
            500                 505                 510         
Met Gly Lys Gly Ser Met Thr Gly Leu Ala Leu Lys His Met Phe Glu
        515                 520                 525             
Arg Ser Phe Thr Gln Gly Glu Gly Ala Arg Pro Leu Ser Thr Arg Val
    530                 535                 540                 
Pro Arg Ala Ala Ile Val Phe Thr Asp Gly Arg Ala Gln Asp Asp Val
545                 550                 555                 560 
Ser Glu Trp Ala Ser Lys Ala Lys Ala Asn Gly Ile Thr Met Tyr Ala
                565                 570                 575     
Val Gly Val Gly Lys Ala Ile Glu Glu Glu Leu Gln Glu Ile Ala Ser
            580                 585                 590         
Glu Pro Thr Asn Lys His Leu Phe Tyr Ala Glu Asp Phe Ser Thr Met
        595                 600                 605             
Asp Glu Ile Ser Glu Lys Leu Lys Lys Gly Ile Cys Glu Ala Leu Glu
    610                 615                 620                 
Asp Ser Asp Gly Arg Gln Asp Ser Pro Ala Gly Glu Leu Pro Lys Thr
625                 630                 635                 640 
Val Gln Gln Pro Thr Glu Ser Glu Pro Val Thr Ile Asn Ile Gln Asp
                645                 650                 655     
Leu Leu Ser Cys Ser Asn Phe Ala Val Gln His Arg Tyr Leu Phe Glu
            660                 665                 670         
Glu Asp Asn Leu Leu Arg Ser Thr Gln Lys Leu Ser His Ser Thr Lys
        675                 680                 685             
Pro Ser Gly Ser Pro Leu Glu Glu Lys His Asp Gln Cys Lys Cys Glu
    690                 695                 700                 
Asn Leu Ile Met Phe Gln Asn Leu Ala Asn Glu Glu Val Arg Lys Leu
705                 710                 715                 720 
Thr Gln Arg Leu Glu Glu Met Thr Gln Arg Met Glu Ala Leu Glu Asn
                725                 730                 735     
Arg Leu Arg Tyr Arg
            740     


<210> 1188
<211> 161
<212> PRT
<213> Homo sapiens

<400> 1188
Ser Ala Glu Val Thr Ser Ser Thr Tyr Ser Asp Glu Asp Arg Pro Pro
 1               5                  10                  15      
Lys Val Pro Pro Arg Glu Pro Leu Ser Pro Ser Asn Ser Arg Thr Pro
            20                  25                  30          
Ser Pro Lys Ser Leu Pro Ser Tyr Leu Asn Gly Val Met Pro Pro Thr
        35                  40                  45              
Gln Ser Phe Ala Pro Asp Pro Lys Tyr Val Ser Ser Lys Ala Leu Gln
    50                  55                  60                  
Arg Gln Asn Ser Glu Gly Ser Ala Ser Lys Val Pro Cys Ile Leu Pro
65                  70                  75                  80  
Ile Ile Glu Asn Gly Lys Lys Val Ser Ser Thr His Tyr Tyr Leu Leu
                85                  90                  95      
Pro Glu Arg Pro Pro Tyr Leu Asp Lys Tyr Glu Lys Phe Phe Arg Glu
            100                 105                 110         
Ala Glu Glu Thr Asn Gly Gly Ala Gln Ile Gln Pro Leu Pro Ala Asp
        115                 120                 125             
Cys Gly Ile Ser Ser Ala Thr Glu Lys Pro Asp Ser Lys Thr Lys Met
    130                 135                 140                 
Asp Leu Gly Gly His Val Lys Arg Lys His Leu Ser Tyr Val Val Ser
145                 150                 155                 160 
Pro
    


<210> 1189
<211> 594
<212> PRT
<213> Homo sapiens

<400> 1189
Gly Val Thr Thr Leu Arg Gln Arg Arg Lys Pro Val Phe His Leu Ser
 1               5                  10                  15      
His Glu Glu Arg Val Gln His Arg Asn Ile Lys Asp Leu Lys Leu Ala
            20                  25                  30          
Phe Ser Glu Phe Tyr Leu Ser Leu Ile Leu Leu Gln Asn Tyr Gln Asn
        35                  40                  45              
Leu Asn Phe Thr Gly Phe Arg Lys Ile Leu Lys Lys His Asp Lys Ile
    50                  55                  60                  
Leu Glu Thr Ser Arg Gly Ala Asp Trp Arg Val Ala His Val Glu Val
65                  70                  75                  80  
Ala Pro Phe Tyr Thr Cys Lys Lys Ile Asn Gln Leu Ile Ser Glu Thr
                85                  90                  95      
Glu Ala Val Val Thr Asn Glu Leu Glu Asp Gly Asp Arg Gln Lys Ala
            100                 105                 110         
Met Lys Arg Leu Arg Val Pro Pro Leu Gly Ala Ala Gln Pro Ala Pro
        115                 120                 125             
Ala Trp Thr Thr Phe Arg Val Gly Leu Phe Cys Gly Ile Phe Ile Val
    130                 135                 140                 
Leu Asn Ile Thr Leu Val Leu Ala Ala Val Phe Lys Leu Glu Thr Asp
145                 150                 155                 160 
Arg Ser Ile Trp Pro Leu Ile Arg Ile Tyr Arg Gly Gly Phe Leu Leu
                165                 170                 175     
Ile Glu Phe Leu Phe Leu Leu Gly Ile Asn Thr Tyr Gly Trp Arg Gln
            180                 185                 190         
Ala Gly Val Asn His Val Leu Ile Phe Glu Leu Asn Pro Arg Ser Asn
        195                 200                 205             
Leu Ser His Gln His Leu Phe Glu Ile Ala Gly Phe Leu Gly Ile Leu
    210                 215                 220                 
Trp Cys Leu Ser Leu Leu Ala Cys Phe Phe Ala Pro Ile Ser Val Ile
225                 230                 235                 240 
Pro Thr Tyr Val Tyr Pro Leu Ala Leu Tyr Gly Phe Met Val Phe Phe
                245                 250                 255     
Leu Ile Asn Pro Thr Lys Thr Phe Tyr Tyr Lys Ser Arg Phe Trp Leu
            260                 265                 270         
Leu Lys Leu Leu Phe Arg Val Phe Thr Ala Pro Phe His Lys Val Gly
        275                 280                 285             
Phe Ala Asp Phe Trp Leu Ala Asp Gln Leu Asn Ser Leu Ser Val Ile
    290                 295                 300                 
Leu Met Asp Leu Glu Tyr Met Ile Cys Phe Tyr Ser Leu Glu Leu Lys
305                 310                 315                 320 
Trp Asp Glu Ser Lys Gly Leu Leu Pro Asn Asn Ser Glu Glu Ser Gly
                325                 330                 335     
Ile Cys His Lys Tyr Thr Tyr Gly Val Arg Ala Ile Val Gln Cys Ile
            340                 345                 350         
Pro Ala Trp Leu Arg Phe Ile Gln Cys Leu Arg Arg Tyr Arg Asp Thr
        355                 360                 365             
Lys Arg Ala Phe Pro His Leu Val Asn Ala Gly Lys Tyr Ser Thr Thr
    370                 375                 380                 
Phe Phe Met Val Thr Phe Ala Ala Leu Tyr Ser Thr His Lys Glu Arg
385                 390                 395                 400 
Gly His Ser Asp Thr Met Val Phe Phe Tyr Leu Trp Ile Val Phe Tyr
                405                 410                 415     
Ile Ile Ser Ser Cys Tyr Thr Leu Ile Trp Asp Leu Lys Met Asp Trp
            420                 425                 430         
Gly Leu Phe Asp Lys Asn Ala Gly Glu Asn Thr Phe Leu Arg Glu Glu
        435                 440                 445             
Ile Val Tyr Pro Gln Lys Ala Tyr Tyr Tyr Cys Ala Ile Ile Glu Asp
    450                 455                 460                 
Val Ile Leu Arg Phe Ala Trp Thr Ile Gln Ile Ser Ile Thr Ser Thr
465                 470                 475                 480 
Thr Leu Leu Pro His Ser Gly Asp Ile Ile Ala Thr Val Phe Ala Pro
                485                 490                 495     
Leu Glu Val Phe Arg Arg Phe Val Trp Asn Phe Phe Arg Leu Glu Asn
            500                 505                 510         
Glu His Leu Asn Asn Cys Gly Glu Phe Arg Ala Val Arg Asp Ile Ser
        515                 520                 525             
Val Ala Pro Leu Asn Ala Asp Asp Gln Thr Leu Leu Glu Gln Met Met
    530                 535                 540                 
Asp Gln Asp Asp Gly Val Arg Asn Arg Gln Lys Asn Arg Ser Trp Lys
545                 550                 555                 560 
Tyr Asn Gln Ser Ile Ser Leu Arg Arg Pro Arg Leu Ala Ser Gln Ser
                565                 570                 575     
Lys Ala Arg Asp Thr Lys Val Leu Ile Glu Asp Thr Asp Asp Glu Ala
            580                 585                 590         
Asn Thr
        


<210> 1190
<211> 185
<212> PRT
<213> Homo sapiens

<400> 1190
Pro Thr Ser Ser Asn Asp Asp Ser Lys Ser Asn Leu Asn Thr Ser Gly
 1               5                  10                  15      
Lys Thr Thr Ser Ser Thr Asp Gly Pro Lys Phe Pro Gly Asp Lys Ser
            20                  25                  30          
Ser Thr Thr Gln Asn Asn Asn Gln Gln Lys Lys Gly Ile Gln Val Leu
        35                  40                  45              
Pro Asp Gly Arg Val Thr Asn Ile Pro Gln Gly Met Val Thr Asp Gln
    50                  55                  60                  
Phe Gly Met Ile Gly Leu Leu Thr Phe Ile Arg Ala Ala Glu Thr Asp
65                  70                  75                  80  
Pro Gly Met Val His Leu Ala Leu Gly Ser Asp Leu Thr Thr Leu Gly
                85                  90                  95      
Leu Asn Leu Asn Ser Pro Glu Asn Leu Tyr Pro Lys Phe Ala Ser Pro
            100                 105                 110         
Trp Ala Ser Ser Pro Cys Arg Pro Gln Asp Ile Asp Phe His Val Pro
        115                 120                 125             
Ser Glu Tyr Leu Thr Asn Ile His Ile Arg Asp Lys Leu Ala Ala Ile
    130                 135                 140                 
Lys Leu Gly Arg Tyr Gly Glu Asp Leu Leu Phe Tyr Leu Tyr Tyr Met
145                 150                 155                 160 
Asn Gly Gly Asp Val Leu Gln Leu Leu Ala Ala Val Glu Leu Tyr Val
                165                 170                 175     
Gln Ser Ile Leu Ile Thr Phe Val Leu
            180                 185 


<210> 1191
<211> 240
<212> PRT
<213> Homo sapiens

<400> 1191
Ile Ile Ser Ala Pro Arg His Gly Ser Ile Ile Tyr His Pro Ser Leu
 1               5                  10                  15      
Leu Pro Arg His Arg Gly Ala Ser Ala Ile Asn Trp Thr Leu Ile His
            20                  25                  30          
Gly Asp Lys Lys Gly Gly Phe Ser Ile Phe Trp Ala Asp Asp Gly Leu
        35                  40                  45              
Asp Thr Gly Asp Leu Leu Leu Gln Lys Glu Cys Glu Val Leu Pro Asp
    50                  55                  60                  
Asp Thr Val Ser Thr Leu Tyr Asn Arg Phe Leu Phe Pro Glu Gly Ile
65                  70                  75                  80  
Lys Gly Met Ala Val Arg Leu Ile Ala Glu Gly Lys Ala Pro Arg Leu
                85                  90                  95      
Pro Gln Pro Glu Glu Gly Ala Thr Tyr Glu Gly Ile Gln Lys Lys Glu
            100                 105                 110         
Thr Ala Lys Ile Asn Trp Asp Gln Pro Ala Glu Ala Ile His Asn Trp
        115                 120                 125             
Ile Arg Gly Asn Asp Lys Val Pro Gly Ala Trp Thr Glu Ala Cys Glu
    130                 135                 140                 
Gln Lys Leu Thr Phe Phe Asn Ser Thr Leu Asn Thr Ser Gly Leu Val
145                 150                 155                 160 
Pro Glu Gly Asp Ala Leu Pro Ile Pro Gly Ala His Arg Pro Gly Val
                165                 170                 175     
Val Thr Lys Ala Gly Leu Ile Leu Phe Gly Asn Asp Asp Lys Met Val
            180                 185                 190         
Arg Ala Arg Leu Trp Val Thr Cys Leu Leu Lys Ala Thr His Ala Pro
        195                 200                 205             
Val Leu Gly Leu Arg Pro His Arg Lys Thr Leu Gly Ser Ser Gly Glu
    210                 215                 220                 
Asn Gly Lys Asn Gln Thr Gln Glu Gly Thr Leu Thr Leu Ile Cys Pro
225                 230                 235                 240 


<210> 1192
<211> 240
<212> PRT
<213> Homo sapiens

<400> 1192
Ile Ile Ser Ala Pro Arg His Gly Ser Ile Ile Tyr His Pro Ser Leu
 1               5                  10                  15      
Leu Pro Arg His Arg Gly Ala Ser Ala Ile Asn Trp Thr Leu Ile His
            20                  25                  30          
Gly Asp Lys Lys Gly Gly Phe Ser Ile Phe Trp Ala Asp Asp Gly Leu
        35                  40                  45              
Asp Thr Gly Asp Leu Leu Leu Gln Lys Glu Cys Glu Val Leu Pro Asp
    50                  55                  60                  
Asp Thr Val Ser Thr Leu Tyr Asn Arg Phe Leu Phe Pro Glu Gly Ile
65                  70                  75                  80  
Lys Gly Met Ala Val Arg Leu Ile Ala Glu Gly Lys Ala Pro Arg Leu
                85                  90                  95      
Pro Gln Pro Glu Glu Gly Ala Thr Tyr Glu Gly Ile Gln Lys Lys Glu
            100                 105                 110         
Thr Ala Lys Ile Asn Trp Asp Gln Pro Ala Glu Ala Ile His Asn Trp
        115                 120                 125             
Ile Arg Gly Asn Asp Lys Val Pro Gly Ala Trp Thr Glu Ala Cys Glu
    130                 135                 140                 
Gln Lys Leu Thr Phe Phe Asn Ser Thr Leu Asn Thr Ser Gly Leu Val
145                 150                 155                 160 
Pro Glu Gly Asp Ala Leu Pro Ile Pro Gly Ala His Arg Pro Gly Val
                165                 170                 175     
Val Thr Lys Ala Gly Leu Ile Leu Phe Gly Asn Asp Asp Lys Met Val
            180                 185                 190         
Arg Ala Arg Leu Trp Val Thr Cys Leu Leu Lys Ala Thr His Ala Pro
        195                 200                 205             
Val Leu Gly Leu Arg Pro His Arg Lys Thr Leu Gly Ser Ser Gly Glu
    210                 215                 220                 
Asn Gly Lys Asn Gln Thr Gln Glu Gly Thr Leu Thr Leu Ile Cys Pro
225                 230                 235                 240 


<210> 1193
<211> 540
<212> PRT
<213> Homo sapiens

<400> 1193
Asn Ser Val Arg Leu Trp Lys Ala Ala Val Glu Leu Glu Glu Pro Glu
 1               5                  10                  15      
Asp Ala Arg Ile Met Leu Ser Arg Ala Val Glu Cys Cys Pro Thr Ser
            20                  25                  30          
Val Glu Leu Trp Leu Ala Leu Ala Arg Leu Glu Thr Tyr Glu Asn Ala
        35                  40                  45              
Arg Lys Val Leu Asn Lys Ala Arg Glu Asn Ile Pro Thr Asp Arg His
    50                  55                  60                  
Ile Trp Ile Thr Ala Ala Lys Leu Glu Glu Ala Asn Gly Asn Thr Gln
65                  70                  75                  80  
Met Val Glu Lys Ile Ile Asp Arg Ala Ile Thr Ser Leu Arg Ala Asn
                85                  90                  95      
Gly Val Glu Ile Asn Arg Glu Gln Trp Ile Gln Asp Ala Glu Glu Cys
            100                 105                 110         
Asp Arg Ala Gly Ser Val Ala Thr Cys Gln Ala Val Met Arg Ala Val
        115                 120                 125             
Ile Gly Ile Gly Ile Glu Glu Glu Asp Arg Lys His Thr Trp Met Glu
    130                 135                 140                 
Asp Ala Asp Ser Cys Val Ala His Asn Ala Leu Glu Cys Ala Arg Ala
145                 150                 155                 160 
Ile Tyr Ala Tyr Ala Leu Gln Val Phe Pro Ser Lys Lys Ser Val Trp
                165                 170                 175     
Leu Arg Ala Ala Tyr Phe Glu Lys Asn His Gly Thr Arg Glu Ser Leu
            180                 185                 190         
Glu Ala Leu Leu Gln Arg Ala Val Ala His Cys Pro Lys Ala Glu Val
        195                 200                 205             
Leu Trp Leu Met Gly Ala Lys Ser Lys Trp Leu Ala Gly Asp Val Pro
    210                 215                 220                 
Ala Ala Arg Ser Ile Leu Ala Leu Ala Phe Gln Ala Asn Pro Asn Ser
225                 230                 235                 240 
Glu Glu Ile Trp Leu Ala Ala Val Lys Leu Glu Ser Glu Asn Asp Glu
                245                 250                 255     
Tyr Glu Arg Ala Arg Arg Leu Leu Ala Lys Ala Arg Ser Ser Ala Pro
            260                 265                 270         
Thr Ala Arg Val Phe Met Lys Ser Val Lys Leu Glu Trp Val Gln Asp
        275                 280                 285             
Asn Ile Arg Ala Ala Gln Asp Leu Cys Glu Glu Ala Leu Arg His Tyr
    290                 295                 300                 
Glu Asp Phe Pro Lys Leu Trp Met Met Lys Gly Gln Ile Glu Glu Gln
305                 310                 315                 320 
Lys Glu Met Met Glu Lys Ala Arg Glu Ala Tyr Asn Gln Gly Leu Lys
                325                 330                 335     
Lys Cys Pro His Ser Thr Pro Leu Trp Leu Leu Leu Ser Arg Leu Glu
            340                 345                 350         
Glu Lys Ile Gly Gln Leu Thr Arg Ala Arg Ala Ile Leu Glu Lys Ser
        355                 360                 365             
Arg Leu Lys Asn Pro Lys Asn Pro Gly Leu Trp Leu Glu Ser Val Arg
    370                 375                 380                 
Leu Glu Tyr Arg Ala Gly Leu Lys Asn Ile Ala Asn Thr Leu Met Ala
385                 390                 395                 400 
Lys Ala Leu Gln Glu Cys Pro Asn Ser Gly Ile Leu Trp Ser Glu Ala
                405                 410                 415     
Ile Phe Leu Glu Ala Arg Pro Gln Arg Arg Thr Lys Ser Val Asp Ala
            420                 425                 430         
Leu Lys Lys Cys Glu His Asp Pro His Val Leu Leu Ala Val Ala Lys
        435                 440                 445             
Leu Phe Trp Ser Gln Arg Lys Ile Thr Lys Ala Arg Glu Trp Phe His
    450                 455                 460                 
Arg Thr Val Lys Ile Asp Ser Asp Leu Gly Asp Ala Trp Ala Phe Phe
465                 470                 475                 480 
Tyr Lys Phe Glu Leu Gln His Gly Thr Glu Glu Gln Gln Glu Glu Val
                485                 490                 495     
Arg Lys Arg Cys Glu Ser Ala Glu Pro Arg His Gly Glu Leu Trp Cys
            500                 505                 510         
Ala Val Ser Lys Asp Ile Ala Asn Trp Gln Lys Lys Ile Gly Asp Ile
        515                 520                 525             
Leu Arg Leu Val Ala Gly Arg Ile Lys Asn Thr Phe
    530                 535                 540 


<210> 1194
<211> 877
<212> PRT
<213> Homo sapiens

<400> 1194
Ile Arg Leu Val Pro Cys Pro Pro Val Cys Ser Asp Ala Phe Ala Leu
 1               5                  10                  15      
Val Ser Asn Leu Ser Pro Tyr Ser His Asp Glu Gly Cys Leu Ser Ser
            20                  25                  30          
Ser Gln Asp His Ile Pro Leu Ala Ala Leu Pro Leu Leu Ala Thr Ser
        35                  40                  45              
Ser Pro Gln Tyr Gln Glu Ala Val Ala Thr Val Ile Gln Arg Ala Asn
    50                  55                  60                  
Leu Ala Tyr Gly Asp Phe Ile Lys Ser Gln Glu Gly Met Thr Phe Asn
65                  70                  75                  80  
Gly Gln Val Cys Leu Ile Gly Asp Cys Val Gly Gly Ile Leu Ala Phe
                85                  90                  95      
Asp Ala Leu Cys Tyr Ser Asn Gln Pro Val Ser Glu Ser Gln Ser Ser
            100                 105                 110         
Ser Arg Arg Gly Ser Val Val Ser Met Gln Asp Asn Asp Leu Leu Ser
        115                 120                 125             
Pro Gly Ile Leu Met Asn Ala Ala His Cys Cys Gly Gly Gly Gly Gly
    130                 135                 140                 
Gly Gly Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly Ser Ser Gly Gly
145                 150                 155                 160 
Ser Ser Leu Glu Ser Ser Arg His Leu Ser Arg Ser Asn Val Asp Ile
                165                 170                 175     
Pro Arg Ser Asn Gly Thr Glu Asp Pro Lys Arg Gln Leu Pro Arg Lys
            180                 185                 190         
Arg Ser Asp Ser Ser Thr Tyr Glu Leu Asp Thr Ile Gln Gln His Gln
        195                 200                 205             
Ala Phe Leu Ser Ser Leu His Ala Ser Val Leu Arg Thr Glu Pro Cys
    210                 215                 220                 
Ser Arg His Ser Ser Ser Ser Thr Met Leu Asp Gly Thr Gly Ala Leu
225                 230                 235                 240 
Gly Arg Phe Asp Phe Glu Ile Thr Asp Leu Phe Leu Phe Gly Cys Pro
                245                 250                 255     
Leu Gly Leu Val Leu Ala Leu Arg Lys Thr Val Ile Pro Ala Leu Asp
            260                 265                 270         
Val Phe Gln Leu Arg Pro Ala Cys Gln Gln Val Tyr Asn Leu Phe His
        275                 280                 285             
Pro Ala Asp Pro Ser Ala Ser Arg Leu Glu Pro Leu Leu Glu Arg Arg
    290                 295                 300                 
Phe His Ala Leu Pro Pro Phe Ser Val Pro Arg Tyr Gln Arg Tyr Pro
305                 310                 315                 320 
Leu Gly Asp Gly Cys Ser Thr Leu Leu Ala Asp Val Leu Gln Thr His
                325                 330                 335     
Asn Ala Ala Phe Gln Glu His Gly Ala Pro Ser Ser Pro Gly Thr Ala
            340                 345                 350         
Pro Ala Ser Arg Gly Phe Arg Arg Ala Ser Glu Ile Ser Ile Ala Ser
        355                 360                 365             
Gln Val Ser Gly Met Ala Glu Ser Tyr Thr Ala Ser Ser Ile Ala Gln
    370                 375                 380                 
Lys Ala Pro Asp Ala Leu Ser His Thr Pro Ser Val Arg Arg Leu Ser
385                 390                 395                 400 
Leu Leu Ala Leu Pro Ala Pro Ser Pro Thr Thr Pro Gly Pro His Pro
                405                 410                 415     
Pro Ala Arg Lys Ala Ser Pro Gly Leu Glu Arg Ala Pro Gly Leu Pro
            420                 425                 430         
Glu Leu Asp Ile Gly Glu Val Ala Ala Lys Trp Trp Gly Gln Lys Arg
        435                 440                 445             
Ile Asp Tyr Ala Leu Tyr Cys Pro Asp Ala Leu Thr Ala Phe Pro Thr
    450                 455                 460                 
Val Ala Leu Pro His Leu Phe His Ala Ser Tyr Trp Glu Ser Thr Asp
465                 470                 475                 480 
Val Val Ser Phe Leu Leu Arg Gln Val Met Arg His Asp Asn Ser Ser
                485                 490                 495     
Ile Leu Glu Leu Asp Gly Lys Glu Val Ser Val Phe Thr Pro Ser Lys
            500                 505                 510         
Pro Arg Glu Lys Trp Gln Arg Lys Arg Thr His Val Lys Leu Arg Asn
        515                 520                 525             
Val Thr Ala Asn His Arg Ile Asn Asp Ala Leu Ala Asn Glu Asp Gly
    530                 535                 540                 
Pro Gln Val Leu Thr Gly Arg Phe Met Tyr Gly Pro Leu Asp Met Val
545                 550                 555                 560 
Thr Leu Thr Gly Glu Lys Val Asp Val His Ile Met Thr Gln Pro Pro
                565                 570                 575     
Ser Gly Glu Trp Leu Tyr Leu Asp Thr Leu Val Thr Asn Asn Ser Gly
            580                 585                 590         
Arg Val Ser Tyr Thr Ile Pro Glu Ser His Arg Leu Gly Val Gly Val
        595                 600                 605             
Tyr Pro Ile Lys Met Val Val Arg Gly Asp His Thr Phe Ala Asp Ser
    610                 615                 620                 
Tyr Ile Thr Val Leu Pro Lys Gly Thr Glu Phe Val Val Phe Ser Ile
625                 630                 635                 640 
Asp Gly Ser Phe Ala Ala Ser Val Ser Ile Met Gly Ser Asp Pro Lys
                645                 650                 655     
Val Arg Ala Gly Ala Val Asp Val Val Arg His Trp Gln Asp Leu Gly
            660                 665                 670         
Tyr Leu Ile Ile Tyr Val Thr Gly Arg Pro Asp Met Gln Lys Gln Arg
        675                 680                 685             
Val Val Ala Trp Leu Ala Gln His Asn Phe Pro His Gly Val Val Ser
    690                 695                 700                 
Phe Cys Asp Gly Leu Val His Asp Pro Leu Arg His Lys Ala Asn Phe
705                 710                 715                 720 
Leu Lys Leu Leu Ile Ser Glu Leu His Leu Arg Val His Ala Ala Tyr
                725                 730                 735     
Gly Ser Thr Lys Asp Val Ala Val Tyr Ser Ala Ile Ser Leu Ser Pro
            740                 745                 750         
Met Gln Ile Tyr Ile Val Gly Arg Pro Thr Lys Lys Leu Gln Gln Gln
        755                 760                 765             
Cys Gln Phe Ile Thr Asp Gly Tyr Ala Ala His Leu Ala Gln Leu Lys
    770                 775                 780                 
Tyr Ser His Arg Ala Arg Pro Ala Arg Asn Thr Ala Thr Arg Met Ala
785                 790                 795                 800 
Leu Arg Lys Gly Ser Phe Gly Leu Pro Gly Gln Gly Asp Phe Leu Arg
                805                 810                 815     
Ser Arg Asn His Leu Leu Arg Thr Ile Ser Ala Gln Pro Ser Gly Pro
            820                 825                 830         
Ser His Arg His Glu Arg Thr Gln Ser Gln Ala Asp Gly Glu Gln Arg
        835                 840                 845             
Gly Gln Arg Ser Met Ser Val Ala Ala Gly Cys Trp Gly Arg Ala Met
    850                 855                 860                 
Thr Gly Arg Leu Glu Pro Gly Ala Ala Ala Gly Pro Lys
865                 870                 875         


<210> 1195
<211> 188
<212> PRT
<213> Homo sapiens

<400> 1195
Gly Leu Met Arg Ser Ile Gly Asn Lys Asn Thr Ile Leu Leu Gly Leu
 1               5                  10                  15      
Gly Phe Gln Ile Leu Gln Leu Ala Trp Tyr Gly Phe Gly Ser Glu Pro
            20                  25                  30          
Trp Met Met Trp Ala Ala Gly Ala Val Ala Ala Met Ser Ser Ile Thr
        35                  40                  45              
Phe Pro Ala Val Ser Ala Leu Val Ser Arg Thr Ala Asp Ala Asp Gln
    50                  55                  60                  
Gln Gly Val Val Gln Gly Met Ile Thr Gly Ile Arg Gly Leu Cys Asn
65                  70                  75                  80  
Gly Leu Gly Pro Ala Leu Tyr Gly Phe Ile Phe Tyr Ile Phe His Val
                85                  90                  95      
Glu Leu Lys Glu Leu Pro Ile Thr Gly Thr Asp Leu Gly Thr Asn Thr
            100                 105                 110         
Ser Pro Gln His His Phe Glu Gln Asn Ser Ile Ile Pro Gly Pro Pro
        115                 120                 125             
Phe Leu Phe Gly Ala Cys Ser Val Leu Leu Ala Leu Leu Val Ala Leu
    130                 135                 140                 
Leu Ile Pro Glu His Thr Asn Leu Ser Leu Arg Ser Ser Ser Trp Arg
145                 150                 155                 160 
Lys His Cys Gly Ser His Ser His Pro His Asn Thr Gln Ala Pro Gly
                165                 170                 175     
Glu Ala Lys Glu Pro Leu Leu Gln Asp Thr Asn Val
            180                 185             


<210> 1196
<211> 644
<212> PRT
<213> Homo sapiens

<400> 1196
Val Gln Ala Ser Ser Pro Ala Glu Val Pro Val Ser Gln Pro Asp Pro
 1               5                  10                  15      
Leu Pro Ala Ser Asp His Ser Tyr Glu Leu Arg Asn Gly Glu Ala Ile
            20                  25                  30          
Gly Arg Asp Arg Arg Gly Arg Arg Ala Arg Arg Asn Asn Ser Gly Glu
        35                  40                  45              
Ala Gly Gly Ala Ala Thr Gln Glu Leu Phe Cys Ser Ala Cys Asp Gln
    50                  55                  60                  
Leu Phe Leu Ser Pro His Gln Leu Gln Gln His Leu Arg Ser His Arg
65                  70                  75                  80  
Glu Gly Val Phe Lys Cys Pro Leu Cys Ser Arg Val Phe Pro Ser Pro
                85                  90                  95      
Ser Ser Leu Asp Gln His Leu Gly Asp His Ser Ser Glu Ser His Phe
            100                 105                 110         
Leu Cys Val Asp Cys Gly Leu Ala Phe Gly Thr Glu Ala Leu Leu Leu
        115                 120                 125             
Ala His Arg Arg Ala His Thr Pro Asn Pro Leu His Ser Cys Pro Cys
    130                 135                 140                 
Gly Lys Thr Phe Val Asn Leu Thr Lys Phe Leu Tyr His Arg Arg Thr
145                 150                 155                 160 
His Gly Val Gly Gly Val Pro Leu Pro Thr Thr Pro Val Pro Pro Glu
                165                 170                 175     
Glu Pro Val Ile Gly Phe Pro Glu Pro Ala Pro Ala Glu Thr Gly Glu
            180                 185                 190         
Pro Glu Ala Pro Glu Pro Pro Val Ser Glu Glu Thr Ser Ala Gly Pro
        195                 200                 205             
Ala Ala Pro Gly Thr Tyr Arg Cys Leu Leu Cys Ser Arg Glu Phe Gly
    210                 215                 220                 
Lys Ala Leu Gln Leu Thr Arg His Gln Arg Phe Val His Arg Leu Glu
225                 230                 235                 240 
Arg Arg His Lys Cys Ser Ile Cys Gly Lys Met Phe Lys Lys Lys Ser
                245                 250                 255     
His Val Arg Asn His Leu Arg Thr His Thr Gly Glu Arg Pro Phe Pro
            260                 265                 270         
Cys Pro Asp Cys Ser Lys Pro Phe Asn Ser Pro Ala Asn Leu Ala Arg
        275                 280                 285             
His Arg Leu Thr His Thr Gly Glu Arg Pro Tyr Arg Cys Gly Asp Cys
    290                 295                 300                 
Gly Lys Ala Phe Thr Gln Ser Ser Thr Leu Arg Gln His Arg Leu Val
305                 310                 315                 320 
His Ala Gln His Phe Pro Tyr Arg Cys Gln Glu Cys Gly Val Arg Phe
                325                 330                 335     
His Arg Pro Tyr Arg Leu Leu Met His Arg Tyr His His Thr Gly Glu
            340                 345                 350         
Tyr Pro Tyr Lys Cys Arg Glu Cys Pro Arg Ser Phe Leu Leu Arg Arg
        355                 360                 365             
Leu Leu Glu Val His Gln Leu Val Val His Ala Gly Arg Gln Pro His
    370                 375                 380                 
Arg Cys Pro Ser Cys Gly Ala Ala Phe Pro Ser Ser Leu Arg Leu Arg
385                 390                 395                 400 
Glu His Arg Cys Ala Ala Ala Ala Ala Gln Ala Pro Arg Arg Phe Glu
                405                 410                 415     
Cys Gly Thr Cys Gly Lys Lys Val Gly Ser Ala Ala Arg Leu Gln Ala
            420                 425                 430         
His Glu Ala Ala His Ala Ala Ala Gly Pro Gly Glu Val Leu Ala Lys
        435                 440                 445             
Glu Pro Pro Ala Pro Arg Ala Pro Arg Ala Thr Arg Ala Pro Val Ala
    450                 455                 460                 
Ser Pro Ala Ala Leu Gly Ser Thr Ala Thr Ala Ser Pro Ala Ala Pro
465                 470                 475                 480 
Ala Arg Arg Arg Gly Leu Glu Cys Ser Glu Cys Lys Lys Leu Phe Ser
                485                 490                 495     
Thr Glu Thr Ser Leu Gln Val His Arg Arg Ile His Thr Gly Glu Arg
            500                 505                 510         
Pro Tyr Pro Cys Pro Asp Cys Gly Lys Ala Phe Arg Gln Ser Thr His
        515                 520                 525             
Leu Lys Asp His Arg Arg Leu His Thr Gly Glu Arg Pro Phe Ala Cys
    530                 535                 540                 
Glu Val Cys Gly Lys Ala Phe Ala Ile Ser Met Arg Leu Ala Glu His
545                 550                 555                 560 
Arg Arg Ile His Thr Gly Glu Arg Pro Tyr Ser Cys Pro Asp Cys Gly
                565                 570                 575     
Lys Ser Tyr Arg Ser Phe Ser Asn Leu Trp Lys His Arg Lys Thr His
            580                 585                 590         
Gln Gln Gln His Gln Ala Ala Val Arg Gln Gln Leu Ala Glu Ala Glu
        595                 600                 605             
Ala Ala Val Gly Leu Ala Val Met Glu Thr Ala Val Glu Ala Leu Pro
    610                 615                 620                 
Leu Val Glu Ala Ile Glu Ile Tyr Pro Leu Ala Glu Ala Glu Gly Val
625                 630                 635                 640 
Gln Ile Ser Gly
                


<210> 1197
<211> 252
<212> PRT
<213> Homo sapiens

<400> 1197
Asp Gly Gly Ala Ser Val Ala Ser Asp Arg Ala Glu Gly Arg Pro Ala
 1               5                  10                  15      
Lys Pro Ser Lys Thr Ala Ala Arg Glu Lys Thr Glu Gly Ala Val Ala
            20                  25                  30          
Ala Val Gly Gly Ala Pro Ser Ser Phe Arg Cys Cys Tyr Gly Cys Cys
        35                  40                  45              
His Glu Ala Arg Leu Gly Arg Thr Ser Leu Pro Arg Gly Val Ile Met
    50                  55                  60                  
Leu Thr Glu Ala Ser Leu Ser Ile Trp Gly Trp Gly Ser Leu Gly Ile
65                  70                  75                  80  
Val Leu Phe Leu Ile Thr Phe Gly Pro Phe Val Ile Phe Tyr Leu Thr
                85                  90                  95      
Phe Tyr Ile Leu Cys Phe Val Gly Gly Gly Leu Val Val Thr Leu Leu
            100                 105                 110         
Phe Gly Lys Thr Asn Ser Glu Lys Tyr Leu Glu Gln Cys Glu His Ser
        115                 120                 125             
Phe Leu Pro Pro Thr Ser Pro Gly Val Pro Lys Cys Leu Glu Glu Met
    130                 135                 140                 
Lys Arg Glu Ala Arg Thr Ile Lys Ile Asp Arg Arg Leu Thr Gly Ala
145                 150                 155                 160 
Asn Ile Ile Asp Glu Pro Leu Gln Gln Val Ile Gln Phe Ser Leu Arg
                165                 170                 175     
Asp Tyr Val Gln Tyr Trp Tyr Tyr Thr Leu Ser Asp Asp Glu Ser Phe
            180                 185                 190         
Leu Leu Glu Ile Arg Gln Thr Leu Gln Asn Ala Leu Ile Gln Phe Ala
        195                 200                 205             
Thr Arg Val Ser Pro Cys Arg Pro Gly Trp Ser Thr Met Ala Gln Ser
    210                 215                 220                 
Arg Leu Thr Ala Thr Ser Ala Ser Trp Asn Pro Val Leu Phe Asn Lys
225                 230                 235                 240 
Thr Leu Val Ser Leu Cys Leu Leu Glu Tyr Val Ile
                245                 250         


<210> 1198
<211> 144
<212> PRT
<213> Homo sapiens

<400> 1198
Leu Arg Tyr Met Lys Glu Ser Gln Val Leu Leu Thr Leu Thr Asn Pro
 1               5                  10                  15      
Val Glu Asn Leu Thr His Val Thr Leu Phe Glu Cys Glu Glu Gly Asp
            20                  25                  30          
Pro Asp Asp Ile Asn Ser Thr Ala Lys Val Val Val Pro Pro Lys Glu
        35                  40                  45              
Leu Val Leu Ala Gly Lys Asp Ala Ala Ala Glu Tyr Asp Glu Leu Ala
    50                  55                  60                  
Glu Pro Gln Asp Phe Gln Asp Asp Pro Asp Ile Ile Ala Phe Arg Lys
65                  70                  75                  80  
Ala Asn Lys Val Gly Ile Phe Ile Lys Val Thr Pro Gln Arg Glu Glu
                85                  90                  95      
Gly Glu Val Thr Val Cys Phe Lys Met Lys His Asp Phe Lys Asn Leu
            100                 105                 110         
Ala Ala Pro Ile Arg Pro Ile Glu Glu Ser Asp Gln Gly Thr Glu Val
        115                 120                 125             
Ile Trp Leu Thr Gln His Val Glu Leu Ser Leu Gly Pro Leu Leu Pro
    130                 135                 140                 


<210> 1199
<211> 1410
<212> PRT
<213> Homo sapiens

<400> 1199
Asp Lys Gly Ile Leu Val Phe Gln Leu Lys Arg Arg Pro Pro Asp His
 1               5                  10                  15      
Ile Pro Lys Lys Thr Lys Lys His Leu Glu Gly Lys Thr Pro Lys Gly
            20                  25                  30          
Lys Glu Arg Ala Asp Gly Ser Gly Tyr Gly Ser Thr Leu Pro Pro Glu
        35                  40                  45              
Lys Leu Pro Tyr Leu Val Glu Leu Ser Pro Gly Arg Arg Asn His Phe
    50                  55                  60                  
Ala Tyr Tyr Asn Tyr His Thr Tyr Glu Asp Gly Ser Asp Ser Arg Asp
65                  70                  75                  80  
Lys Pro Lys Leu Tyr Arg Leu Gln Leu Ser Val Thr Glu Val Gly Thr
                85                  90                  95      
Glu Lys Leu Asp Asp Asn Ser Ile Gln Leu Phe Gly Pro Gly Ile Gln
            100                 105                 110         
Pro His His Cys Asp Leu Thr Asn Met Asp Gly Val Val Thr Val Thr
        115                 120                 125             
Pro Arg Ser Met Asp Ala Glu Thr Tyr Val Glu Gly Gln Arg Ile Ser
    130                 135                 140                 
Glu Thr Thr Met Leu Gln Ser Gly Met Lys Val Gln Phe Gly Ala Ser
145                 150                 155                 160 
His Val Phe Lys Phe Val Asp Pro Ser Gln Asp His Ala Leu Ala Lys
                165                 170                 175     
Arg Ser Val Asp Gly Gly Leu Met Val Lys Gly Pro Arg His Lys Pro
            180                 185                 190         
Gly Ile Val Gln Glu Thr Thr Phe Asp Leu Gly Gly Asp Ile His Ser
        195                 200                 205             
Gly Thr Ala Leu Pro Thr Ser Lys Ser Thr Thr Arg Leu Asp Ser Asp
    210                 215                 220                 
Arg Val Ser Ser Ala Ser Ser Thr Ala Glu Arg Gly Met Val Lys Pro
225                 230                 235                 240 
Met Ile Arg Val Glu Gln Gln Pro Asp Tyr Arg Arg Gln Glu Ser Arg
                245                 250                 255     
Thr Gln Asp Ala Ser Gly Pro Glu Leu Ile Leu Pro Ala Ser Ile Glu
            260                 265                 270         
Phe Arg Glu Ser Ser Glu Asp Ser Phe Leu Ser Ala Ile Ile Asn Tyr
        275                 280                 285             
Thr Asn Ser Ser Thr Val His Phe Lys Leu Ser Pro Thr Tyr Val Leu
    290                 295                 300                 
Tyr Met Ala Cys Arg Tyr Val Leu Ser Asn Gln Tyr Arg Pro Asp Ile
305                 310                 315                 320 
Ser Pro Thr Glu Arg Thr His Lys Val Ile Ala Val Val Asn Lys Met
                325                 330                 335     
Val Ser Met Met Glu Gly Val Ile Gln Lys Gln Lys Asn Ile Ala Gly
            340                 345                 350         
Ala Leu Ala Phe Trp Met Ala Asn Ala Ser Glu Leu Leu Asn Phe Ile
        355                 360                 365             
Lys Gln Asp Arg Asp Leu Ser Arg Ile Thr Leu Asp Ala Gln Asp Val
    370                 375                 380                 
Leu Ala His Leu Val Gln Met Ala Phe Lys Tyr Leu Val His Cys Leu
385                 390                 395                 400 
Gln Ser Glu Leu Asn Asn Tyr Met Pro Ala Phe Leu Asp Asp Pro Glu
                405                 410                 415     
Glu Asn Ser Leu Gln Arg Pro Lys Ile Asp Asp Val Leu His Thr Leu
            420                 425                 430         
Thr Gly Ala Met Ser Leu Leu Arg Arg Cys Arg Val Asn Ala Ala Leu
        435                 440                 445             
Thr Ile Gln Leu Phe Ser Gln Leu Phe His Phe Ile Asn Met Trp Leu
    450                 455                 460                 
Phe Asn Arg Leu Val Thr Asp Pro Asp Ser Gly Leu Cys Ser His Tyr
465                 470                 475                 480 
Trp Gly Ala Ile Ile Arg Gln Gln Leu Gly His Ile Glu Ala Trp Ala
                485                 490                 495     
Glu Lys Gln Gly Leu Glu Leu Ala Ala Asp Cys His Leu Ser Arg Ile
            500                 505                 510         
Val Gln Ala Thr Thr Leu Leu Thr Met Asp Lys Tyr Ala Pro Asp Asp
        515                 520                 525             
Ile Pro Asn Ile Asn Ser Thr Cys Phe Lys Leu Asn Ser Leu Gln Leu
    530                 535                 540                 
Gln Ala Leu Leu Gln Asn Tyr His Cys Ala Pro Asp Glu Pro Phe Ile
545                 550                 555                 560 
Pro Thr Asp Leu Ile Glu Asn Val Val Thr Val Ala Glu Asn Thr Ala
                565                 570                 575     
Asp Glu Leu Ala Arg Ser Asp Gly Arg Glu Val Gln Leu Glu Glu Asp
            580                 585                 590         
Pro Asp Leu Gln Leu Pro Phe Leu Leu Pro Glu Asp Gly Tyr Ser Cys
        595                 600                 605             
Asp Val Val Arg Asn Ile Pro Asn Gly Leu Gln Glu Phe Leu Asp Pro
    610                 615                 620                 
Leu Cys Gln Arg Gly Phe Cys Arg Leu Ile Pro His Thr Arg Ser Pro
625                 630                 635                 640 
Gly Thr Trp Thr Ile Tyr Phe Glu Gly Ala Asp Tyr Glu Ser His Leu
                645                 650                 655     
Leu Arg Glu Asn Thr Glu Leu Ala Gln Pro Leu Arg Lys Glu Pro Glu
            660                 665                 670         
Ile Ile Thr Val Thr Leu Lys Lys Gln Asn Gly Met Gly Leu Ser Ile
        675                 680                 685             
Val Ala Ala Lys Gly Ala Gly Gln Asp Lys Leu Gly Ile Tyr Val Lys
    690                 695                 700                 
Ser Val Val Lys Gly Gly Ala Ala Asp Val Asp Gly Arg Leu Ala Ala
705                 710                 715                 720 
Gly Asp Gln Leu Leu Ser Val Asp Gly Arg Ser Leu Val Gly Leu Ser
                725                 730                 735     
Gln Glu Arg Ala Ala Glu Leu Met Thr Arg Thr Ser Ser Val Val Thr
            740                 745                 750         
Leu Glu Val Ala Lys Gln Gly Ala Ile Tyr His Gly Leu Ala Thr Leu
        755                 760                 765             
Leu Asn Gln Pro Ser Pro Met Met Gln Arg Ile Ser Asp Arg Arg Gly
    770                 775                 780                 
Ser Gly Lys Pro Arg Pro Lys Ser Glu Gly Phe Glu Leu Tyr Asn Asn
785                 790                 795                 800 
Ser Thr Gln Asn Gly Ser Pro Glu Ser Pro Gln Leu Pro Trp Ala Glu
                805                 810                 815     
Tyr Ser Glu Pro Lys Lys Leu Pro Gly Asp Asp Arg Leu Met Lys Asn
            820                 825                 830         
Arg Ala Asp His Arg Ser Ser Pro Asn Val Ala Asn Gln Pro Pro Ser
        835                 840                 845             
Pro Gly Gly Lys Ser Ala Tyr Ala Ser Gly Thr Thr Ala Lys Ile Thr
    850                 855                 860                 
Ser Val Ser Thr Gly Asn Leu Cys Thr Glu Glu Gln Thr Pro Pro Pro
865                 870                 875                 880 
Arg Pro Glu Ala Tyr Pro Ile Pro Thr Gln Thr Tyr Thr Arg Glu Tyr
                885                 890                 895     
Phe Thr Phe Pro Ala Ser Lys Ser Gln Asp Arg Met Ala Pro Pro Gln
            900                 905                 910         
Asn Gln Trp Pro Asn Tyr Glu Glu Lys Pro His Met His Thr Asp Ser
        915                 920                 925             
Asn His Ser Ser Ile Ala Ile Gln Arg Val Thr Arg Ser Gln Glu Glu
    930                 935                 940                 
Leu Arg Glu Asp Lys Ala Tyr Gln Leu Glu Arg His Arg Ile Glu Ala
945                 950                 955                 960 
Ala Met Asp Arg Lys Ser Asp Ser Asp Met Trp Ile Asn Gln Ser Ser
                965                 970                 975     
Ser Leu Asp Ser Ser Thr Ser Ser Gln Glu His Leu Asn His Ser Ser
            980                 985                 990         
Lys Ser Val Thr Pro Ala Ser Thr Leu Thr Lys Ser Gly Pro Gly Arg
        995                 1000                1005            
Trp Lys Thr Pro Ala Ala Ile Pro Ala Thr Pro Val Ala Val Ser Gln
    1010                1015                1020                
Pro Ile Arg Thr Asp Leu Pro Pro Pro Pro Pro Pro Pro Pro Val His
1025                1030                1035                1040
Tyr Ala Gly Asp Phe Asp Gly Met Ser Met Asp Leu Pro Leu Pro Pro
                1045                1050                1055    
Pro Pro Ser Ala Asn Gln Ile Gly Leu Pro Ser Ala Gln Val Ala Ala
            1060                1065                1070        
Ala Glu Arg Arg Lys Arg Glu Glu His Gln Arg Trp Tyr Glu Lys Glu
        1075                1080                1085            
Lys Ala Arg Leu Glu Glu Glu Arg Glu Arg Lys Arg Arg Glu Gln Glu
    1090                1095                1100                
Arg Lys Leu Gly Gln Met Arg Thr Gln Ser Leu Asn Pro Ala Pro Phe
1105                1110                1115                1120
Ser Pro Leu Thr Ala Gln Gln Met Lys Pro Glu Lys Pro Ser Thr Leu
                1125                1130                1135    
Gln Arg Pro Gln Glu Thr Val Ile Arg Glu Leu Gln Pro Gln Gln Gln
            1140                1145                1150        
Pro Arg Thr Ile Glu Arg Arg Asp Leu Gln Tyr Ile Thr Val Ser Lys
        1155                1160                1165            
Glu Glu Leu Ser Ser Gly Thr Val Cys Pro Pro Asp Pro Trp Lys Arg
    1170                1175                1180                
Asp Ala Lys Glu Lys Leu Glu Lys Gln Gln Gln Met His Ile Val Asp
1185                1190                1195                1200
Met Leu Ser Lys Glu Ile Gln Glu Leu Gln Ser Lys Pro Asp Arg Ser
                1205                1210                1215    
Ala Glu Glu Ser Asp Arg Leu Arg Lys Leu Met Leu Glu Trp Gln Phe
            1220                1225                1230        
Gln Lys Arg Leu Gln Glu Ser Lys Gln Lys Asp Glu Asp Asp Glu Glu
        1235                1240                1245            
Glu Glu Asp Asp Asp Val Asp Thr Met Leu Ile Met Gln Arg Leu Glu
    1250                1255                1260                
Ala Glu Arg Arg Ala Arg Thr Ala Met Pro Ala Ile Ser Val Leu Asp
1265                1270                1275                1280
Leu Leu Gln Asp Glu Glu Arg Arg Arg Gln Gln Gln Leu Glu Glu Met
                1285                1290                1295    
Arg Lys Arg Glu Ala Glu Asp Arg Ala Arg Gln Glu Glu Glu Arg Arg
            1300                1305                1310        
Arg Gln Glu Glu Glu Arg Thr Lys Arg Asp Ala Glu Glu Lys Arg Arg
        1315                1320                1325            
Gln Glu Glu Gly Tyr Tyr Ser Arg Leu Glu Ala Glu Arg Arg Arg Gln
    1330                1335                1340                
His Asp Glu Ala Ala Arg Arg Leu Leu Glu Pro Glu Ala Pro Gly Leu
1345                1350                1355                1360
Cys Arg Pro Pro Leu Pro Arg Asp Tyr Glu Pro Pro Ser Pro Ser Pro
                1365                1370                1375    
Ala Arg Arg Pro Ser Ser Pro Ala Ser Ala Lys Arg Leu Leu Pro Gln
            1380                1385                1390        
Asn Thr Gly Pro Leu Pro Arg Leu Ala Val His Cys Gln Val Cys Cys
        1395                1400                1405            
Ile Gln
    1410


<210> 1200
<211> 271
<212> PRT
<213> Homo sapiens

<400> 1200
Asp Gly Met Val His Pro Tyr Lys Gly Asp Arg Ala Glu Tyr Cys Lys
 1               5                  10                  15      
Ala Ala Asn Lys Arg Val Met Asp Val Ile Asn Ser Ala Arg Thr Arg
            20                  25                  30          
Gln Gln Met Leu His Ala Gln Thr Phe His Ser Asn Ser Leu Leu Thr
        35                  40                  45              
Gln Glu Asp Ala Ala Ala Ala Gly Asp Arg Arg Pro Ala Pro Asp Thr
    50                  55                  60                  
Trp Ile Tyr Pro Leu Ile Gln Met Lys Pro Phe Glu Ile Gln Ile Asp
65                  70                  75                  80  
Glu Ile Val Thr Glu Thr Leu Leu Thr Glu Ala Glu Arg Gly Ala Lys
                85                  90                  95      
Val Tyr Leu Thr Thr Gly Tyr Phe Asn Leu Thr Gln Ala Tyr Met Asp
            100                 105                 110         
Leu Val Leu Gly Thr Arg Ala Glu Tyr Gln Ile Leu Leu Ala Ser Pro
        115                 120                 125             
Glu Val Asn Gly Phe Phe Gly Ala Lys Gly Val Ala Gly Ala Ile Pro
    130                 135                 140                 
Ala Ala Tyr Val His Ile Glu Arg Gln Phe Phe Ser Glu Val Cys Ser
145                 150                 155                 160 
Leu Gly Gln Gln Glu Arg Val Gln Leu Gln Glu Tyr Trp Arg Arg Gly
                165                 170                 175     
Trp Thr Phe His Ala Lys Gly Leu Trp Leu Tyr Leu Ala Gly Ser Ser
            180                 185                 190         
Leu Pro Cys Leu Thr Leu Ile Gly Ser Pro Asn Phe Gly Tyr Arg Ser
        195                 200                 205             
Val His Arg Asp Leu Glu Ala Gln Ile Ala Ile Val Thr Glu Asn Gln
    210                 215                 220                 
Ala Leu Gln Gln Gln Leu His Gln Glu Gln Glu Gln Leu Tyr Leu Arg
225                 230                 235                 240 
Ser Gly Val Val Ser Ser Ala Thr Phe Glu Gln Pro Ser Arg Gln Val
                245                 250                 255     
Lys Leu Trp Val Lys Met Val Thr Pro Leu Ile Lys Asn Phe Phe
            260                 265                 270     


<210> 1201
<211> 2175
<212> PRT
<213> Homo sapiens

<400> 1201
Met Val Ile Leu Gln Gln Gly Asp His Val Trp Met Asp Leu Arg Ser
 1               5                  10                  15      
Gly Gln Glu Phe Asp Val Pro Ile Gly Ala Val Val Lys Leu Cys Asp
            20                  25                  30          
Ser Gly Gln Val Gln Val Val Asp Asp Glu Asp Asn Glu His Trp Ile
        35                  40                  45              
Ser Pro Gln Asn Ala Thr His Ile Lys Pro Met His Pro Thr Ser Val
    50                  55                  60                  
His Gly Val Glu Asp Met Ile Arg Leu Gly Asp Leu Asn Glu Ala Gly
65                  70                  75                  80  
Ile Leu Arg Asn Leu Leu Ile Arg Tyr Arg Asp His Leu Ile Tyr Thr
                85                  90                  95      
Tyr Thr Gly Ser Ile Leu Val Ala Val Asn Pro Tyr Gln Leu Leu Ser
            100                 105                 110         
Ile Tyr Ser Pro Glu His Ile Arg Gln Tyr Thr Asn Lys Lys Ile Gly
        115                 120                 125             
Glu Met Pro Pro His Ile Phe Ala Ile Ala Asp Asn Cys Tyr Phe Asn
    130                 135                 140                 
Met Lys Arg Asn Ser Arg Asp Gln Cys Cys Ile Ile Ser Gly Glu Ser
145                 150                 155                 160 
Gly Ala Gly Lys Thr Glu Ser Thr Lys Leu Ile Leu Gln Phe Leu Ala
                165                 170                 175     
Ala Ile Ser Gly Gln His Ser Trp Ile Glu Gln Gln Val Leu Glu Ala
            180                 185                 190         
Thr Pro Ile Leu Glu Ala Phe Gly Asn Ala Lys Thr Ile Arg Asn Asp
        195                 200                 205             
Asn Ser Ser Arg Phe Gly Lys Tyr Ile Asp Ile His Phe Asn Lys Arg
    210                 215                 220                 
Gly Ala Ile Glu Gly Ala Lys Ile Glu Gln Tyr Leu Leu Glu Lys Ser
225                 230                 235                 240 
Arg Val Cys Arg Gln Ala Leu Asp Glu Arg Asn Tyr His Val Phe Tyr
                245                 250                 255     
Cys Met Leu Glu Gly Met Ser Glu Asp Gln Lys Lys Lys Leu Gly Leu
            260                 265                 270         
Gly Gln Ala Ser Asp Tyr Asn Tyr Leu Ala Met Gly Asn Cys Ile Thr
        275                 280                 285             
Cys Glu Gly Arg Val Asp Ser Gln Glu Tyr Ala Asn Ile Arg Ser Ala
    290                 295                 300                 
Met Lys Val Leu Met Phe Thr Asp Thr Glu Asn Trp Glu Ile Ser Lys
305                 310                 315                 320 
Leu Leu Ala Ala Ile Leu His Leu Gly Asn Leu Gln Tyr Glu Ala Arg
                325                 330                 335     
Thr Phe Glu Asn Leu Asp Ala Cys Glu Val Leu Phe Ser Pro Ser Leu
            340                 345                 350         
Ala Thr Ala Ala Ser Leu Leu Glu Val Asn Pro Pro Asp Leu Met Ser
        355                 360                 365             
Cys Leu Thr Ser Arg Thr Leu Ile Thr Arg Gly Glu Thr Val Ser Thr
    370                 375                 380                 
Pro Leu Ser Arg Glu Gln Ala Leu Asp Val Arg Asp Ala Phe Val Lys
385                 390                 395                 400 
Gly Ile Tyr Gly Arg Leu Phe Val Trp Ile Val Asp Lys Ile Asn Ala
                405                 410                 415     
Ala Ile Tyr Lys Pro Pro Ser Gln Asp Val Lys Asn Ser Arg Arg Ser
            420                 425                 430         
Ile Gly Leu Leu Asp Ile Phe Gly Phe Glu Asn Phe Ala Val Asn Ser
        435                 440                 445             
Phe Glu Gln Leu Cys Ile Asn Phe Ala Asn Glu His Leu Gln Gln Phe
    450                 455                 460                 
Phe Val Arg His Val Leu Lys Leu Glu Gln Glu Glu Tyr Asp Leu Glu
465                 470                 475                 480 
Ser Ile Asp Trp Leu His Ile Glu Phe Thr Asp Asn Gln Asp Ala Leu
                485                 490                 495     
Asp Met Ile Ala Asn Lys Pro Met Asn Ile Ile Ser Leu Ile Asp Glu
            500                 505                 510         
Glu Ser Lys Phe Pro Lys Gly Thr Asp Thr Thr Met Leu His Lys Leu
        515                 520                 525             
Asn Ser Gln His Lys Leu Asn Ala Asn Tyr Ile Pro Pro Lys Asn Asn
    530                 535                 540                 
His Glu Thr Gln Phe Gly Ile Asn His Phe Ala Gly Ile Val Tyr Tyr
545                 550                 555                 560 
Glu Thr Gln Gly Phe Leu Glu Lys Asn Arg Asp Thr Leu His Gly Asp
                565                 570                 575     
Ile Ile Gln Leu Val His Ser Ser Arg Asn Lys Phe Ile Lys Gln Ile
            580                 585                 590         
Phe Gln Ala Asp Val Ala Met Gly Ala Glu Thr Arg Lys Arg Ser Pro
        595                 600                 605             
Thr Leu Ser Ser Gln Phe Lys Arg Ser Leu Glu Leu Leu Met Arg Thr
    610                 615                 620                 
Leu Gly Ala Cys Gln Pro Phe Phe Val Arg Cys Ile Lys Pro Asn Glu
625                 630                 635                 640 
Phe Lys Lys Pro Met Leu Phe Asp Arg His Leu Cys Val Arg Gln Leu
                645                 650                 655     
Arg Tyr Ser Gly Met Met Glu Thr Ile Arg Ile Arg Arg Ala Gly Tyr
            660                 665                 670         
Pro Ile Arg Tyr Ser Phe Val Glu Phe Val Glu Arg Tyr Arg Val Leu
        675                 680                 685             
Leu Pro Gly Val Lys Pro Ala Tyr Lys Gln Gly Asp Leu Arg Gly Thr
    690                 695                 700                 
Cys Gln Arg Met Ala Glu Ala Val Leu Gly Thr His Asp Asp Trp Gln
705                 710                 715                 720 
Ile Gly Lys Thr Lys Ile Phe Leu Lys Asp His His Asp Met Leu Leu
                725                 730                 735     
Glu Val Glu Arg Asp Lys Ala Ile Thr Asp Arg Val Ile Leu Leu Gln
            740                 745                 750         
Lys Val Ile Arg Gly Phe Lys Asp Arg Ser Asn Phe Leu Lys Leu Lys
        755                 760                 765             
Asn Ala Ala Thr Leu Ile Gln Arg His Trp Arg Gly His Asn Cys Arg
    770                 775                 780                 
Lys Asn Tyr Gly Leu Met Arg Leu Gly Ser Leu Arg Leu Gln Ala Leu
785                 790                 795                 800 
His Arg Ser Arg Lys Leu His Gln Gln Tyr Arg Leu Ala Arg Gln Arg
                805                 810                 815     
Ile Ile Gln Phe Gln Ala Arg Cys Arg Ala Tyr Leu Val Arg Lys Ala
            820                 825                 830         
Phe Arg His Arg Leu Trp Ala Val Leu Thr Val Gln Ala Tyr Ala Arg
        835                 840                 845             
Gly Met Ile Ala Arg Arg Leu His Gln Arg Leu Arg Ala Glu Tyr Leu
    850                 855                 860                 
Trp Arg Leu Glu Ala Glu Lys Met Gln Leu Ala Glu Glu Glu Lys Leu
865                 870                 875                 880 
Arg Lys Glu Met Ser Ala Lys Lys Ala Lys Glu Glu Ala Glu Arg Lys
                885                 890                 895     
His Gln Glu Arg Leu Ala Gln Leu Ala Arg Glu Asp Ala Glu Arg Glu
            900                 905                 910         
Leu Lys Glu Lys Glu Ala Ala Arg Arg Lys Lys Glu Leu Leu Glu Gln
        915                 920                 925             
Met Glu Arg Ala Arg His Glu Pro Val Asn His Ser Asp Met Val Asp
    930                 935                 940                 
Lys Met Phe Gly Phe Leu Gly Thr Ser Gly Gly Leu Pro Gly Gln Glu
945                 950                 955                 960 
Gly Gln Ala Pro Ser Gly Phe Glu Asp Leu Glu Arg Gly Arg Arg Glu
                965                 970                 975     
Met Val Glu Glu Asp Leu Asp Ala Ala Leu Pro Leu Pro Asp Glu Asp
            980                 985                 990         
Glu Glu Asp Leu Ser Glu Tyr Lys Phe Ala Lys Phe Ala Ala Thr Tyr
        995                 1000                1005            
Phe Gln Gly Thr Thr Thr His Ser Tyr Thr Arg Arg Pro Leu Lys Gln
    1010                1015                1020                
Pro Leu Leu Tyr His Asp Asp Glu Gly Asp Gln Leu Ala Ala Leu Ala
1025                1030                1035                1040
Val Trp Ile Thr Ile Leu Arg Phe Met Gly Asp Leu Pro Glu Pro Lys
                1045                1050                1055    
Tyr His Thr Ala Met Ser Asp Gly Ser Glu Lys Ile Pro Val Met Thr
            1060                1065                1070        
Lys Ile Tyr Glu Thr Leu Gly Lys Lys Thr Tyr Lys Arg Glu Leu Gln
        1075                1080                1085            
Ala Leu Gln Gly Glu Gly Glu Ala Gln Leu Pro Glu Gly Gln Lys Lys
    1090                1095                1100                
Ser Ser Val Arg His Lys Leu Val His Leu Thr Leu Lys Lys Lys Ser
1105                1110                1115                1120
Lys Leu Thr Glu Glu Val Thr Lys Arg Leu His Asp Gly Glu Ser Thr
                1125                1130                1135    
Val Gln Gly Asn Ser Met Leu Glu Asp Arg Pro Thr Ser Asn Leu Glu
            1140                1145                1150        
Lys Leu His Phe Ile Ile Gly Asn Gly Ile Leu Arg Pro Ala Leu Arg
        1155                1160                1165            
Asp Glu Ile Tyr Cys Gln Ile Ser Lys Gln Leu Thr His Asn Pro Ser
    1170                1175                1180                
Lys Ser Ser Tyr Ala Arg Gly Trp Ile Leu Val Ser Leu Cys Val Gly
1185                1190                1195                1200
Cys Phe Ala Pro Ser Glu Lys Phe Val Lys Tyr Leu Arg Asn Phe Ile
                1205                1210                1215    
His Gly Gly Pro Pro Gly Tyr Ala Pro Tyr Cys Glu Glu Arg Leu Arg
            1220                1225                1230        
Arg Thr Phe Val Ser Gly Thr Arg Thr Gln Pro Pro Ser Trp Leu Glu
        1235                1240                1245            
Leu Gln Ala Thr Lys Ser Lys Lys Pro Ile Met Leu Pro Val Thr Phe
    1250                1255                1260                
Met Asp Gly Thr Thr Lys Thr Leu Leu Thr Asp Ser Ala Thr Thr Ala
1265                1270                1275                1280
Lys Glu Leu Cys Asn Ala Leu Ala Asp Lys Ile Ser Leu Lys Asp Arg
                1285                1290                1295    
Phe Gly Phe Ser Leu Tyr Ile Ala Leu Phe Asp Lys Val Ser Ser Leu
            1300                1305                1310        
Gly Ser Gly Ser Asp His Val Met Asp Ala Ile Ser Gln Cys Glu Gln
        1315                1320                1325            
Tyr Ala Lys Glu Gln Gly Ala Gln Glu Arg Asn Ala Pro Trp Arg Leu
    1330                1335                1340                
Phe Phe Arg Lys Glu Val Phe Thr Pro Trp His Ser Pro Ser Glu Asp
1345                1350                1355                1360
Asn Val Ala Thr Asn Leu Ile Tyr Gln Gln Val Val Arg Gly Val Lys
                1365                1370                1375    
Phe Gly Glu Tyr Arg Cys Glu Lys Glu Asp Asp Leu Ala Glu Leu Ala
            1380                1385                1390        
Ser Gln Gln Tyr Phe Val Asp Tyr Gly Ser Glu Met Ile Leu Glu Arg
        1395                1400                1405            
Leu Leu Asn Leu Val Pro Thr Tyr Ile Pro Asp Arg Glu Ile Thr Pro
    1410                1415                1420                
Leu Lys Thr Leu Glu Lys Trp Ala Gln Leu Ala Ile Ala Ala His Lys
1425                1430                1435                1440
Lys Gly Ile Tyr Ala Gln Arg Arg Thr Asp Ala Gln Lys Val Lys Glu
                1445                1450                1455    
Asp Val Val Ser Tyr Ala Arg Phe Lys Trp Pro Leu Leu Phe Ser Arg
            1460                1465                1470        
Phe Tyr Glu Ala Tyr Lys Phe Ser Gly Pro Ser Leu Pro Lys Asn Asp
        1475                1480                1485            
Val Ile Val Ala Val Asn Trp Thr Gly Val Tyr Phe Val Asp Glu Gln
    1490                1495                1500                
Glu Gln Val Leu Leu Glu Leu Ser Phe Pro Glu Ile Met Ala Val Ser
1505                1510                1515                1520
Ser Ser Arg Gly Ala Lys Thr Thr Ala Pro Ser Phe Thr Leu Ala Thr
                1525                1530                1535    
Ile Lys Gly Asp Glu Tyr Thr Phe Thr Ser Ser Asn Ala Glu Asp Ile
            1540                1545                1550        
Arg Asp Leu Val Val Thr Phe Leu Glu Gly Leu Arg Lys Arg Ser Lys
        1555                1560                1565            
Tyr Val Val Ala Leu Gln Asp Asn Pro Asn Pro Ala Gly Glu Glu Ser
    1570                1575                1580                
Gly Phe Leu Ser Phe Ala Lys Gly Asp Leu Ile Ile Leu Asp His Asp
1585                1590                1595                1600
Thr Gly Glu Gln Val Met Asn Ser Gly Trp Ala Asn Gly Ile Asn Glu
                1605                1610                1615    
Arg Thr Lys Gln Arg Gly Asp Phe Pro Thr Asp Ser Val Tyr Val Met
            1620                1625                1630        
Pro Thr Val Thr Met Pro Pro Arg Glu Ile Val Ala Leu Val Thr Met
        1635                1640                1645            
Thr Pro Asp Gln Arg Gln Asp Val Val Arg Leu Leu Gln Leu Arg Thr
    1650                1655                1660                
Ala Glu Pro Glu Val Arg Ala Lys Pro Tyr Thr Leu Glu Glu Phe Ser
1665                1670                1675                1680
Tyr Asp Tyr Phe Arg Pro Pro Pro Lys His Thr Leu Ser Arg Val Met
                1685                1690                1695    
Val Ser Lys Ala Arg Gly Lys Asp Arg Leu Trp Ser His Thr Arg Glu
            1700                1705                1710        
Pro Leu Lys Gln Ala Leu Leu Lys Lys Leu Leu Gly Ser Glu Glu Leu
        1715                1720                1725            
Ser Gln Glu Ala Cys Leu Ala Phe Ile Ala Val Leu Lys Tyr Met Gly
    1730                1735                1740                
Asp Tyr Pro Ser Lys Arg Thr Arg Ser Val Asn Glu Leu Thr Asp Gln
1745                1750                1755                1760
Ile Phe Glu Gly Pro Leu Lys Ala Glu Pro Leu Lys Asp Glu Ala Tyr
                1765                1770                1775    
Val Gln Ile Leu Lys Gln Leu Thr Asp Asn His Ile Arg Tyr Ser Glu
            1780                1785                1790        
Glu Arg Gly Trp Glu Leu Leu Trp Leu Cys Thr Gly Leu Phe Pro Pro
        1795                1800                1805            
Ser Asn Ile Leu Leu Pro His Val Gln Arg Phe Leu Gln Ser Arg Lys
    1810                1815                1820                
His Cys Pro Leu Ala Ile Asp Cys Leu Gln Arg Leu Gln Lys Ala Leu
1825                1830                1835                1840
Arg Asn Gly Ser Arg Lys Tyr Pro Pro His Leu Val Glu Val Glu Ala
                1845                1850                1855    
Ile Gln His Lys Thr Thr Gln Ile Phe His Lys Val Tyr Phe Pro Asp
            1860                1865                1870        
Asp Thr Asp Glu Ala Phe Glu Val Glu Ser Ser Thr Lys Ala Lys Asp
        1875                1880                1885            
Phe Cys Gln Asn Ile Ala Thr Arg Leu Leu Leu Lys Ser Ser Glu Gly
    1890                1895                1900                
Phe Ser Leu Phe Val Lys Ile Ala Asp Lys Val Leu Ser Val Pro Glu
1905                1910                1915                1920
Asn Asp Phe Phe Phe Asp Phe Val Arg His Leu Thr Asp Trp Ile Lys
                1925                1930                1935    
Lys Ala Arg Pro Ile Lys Asp Gly Ile Val Pro Ser Leu Thr Tyr Gln
            1940                1945                1950        
Val Phe Phe Met Lys Lys Leu Trp Thr Thr Thr Val Pro Gly Lys Asp
        1955                1960                1965            
Pro Met Ala Asp Ser Ile Phe His Tyr Tyr Gln Glu Leu Pro Lys Tyr
    1970                1975                1980                
Leu Arg Gly Tyr His Lys Cys Thr Arg Glu Glu Val Leu Gln Leu Gly
1985                1990                1995                2000
Ala Leu Ile Tyr Arg Val Lys Phe Glu Glu Asp Lys Ser Tyr Phe Pro
                2005                2010                2015    
Ser Ile Pro Lys Leu Leu Arg Glu Leu Val Pro Gln Asp Leu Ile Arg
            2020                2025                2030        
Gln Val Ser Pro Asp Asp Trp Lys Arg Ser Ile Val Ala Tyr Phe Asn
        2035                2040                2045            
Lys His Ala Gly Lys Ser Lys Glu Glu Ala Lys Leu Ala Phe Leu Lys
    2050                2055                2060                
Leu Ile Phe Lys Trp Pro Thr Phe Gly Ser Ala Phe Phe Glu Gln Thr
2065                2070                2075                2080
Thr Glu Pro Asn Phe Pro Glu Ile Leu Leu Ile Ala Ile Asn Lys Tyr
                2085                2090                2095    
Gly Val Ser Leu Ile Asp Pro Lys Thr Lys Asp Ile Leu Thr Thr His
            2100                2105                2110        
Pro Phe Thr Lys Ile Ser Asn Trp Ser Ser Gly Asn Thr Tyr Phe His
        2115                2120                2125            
Ile Thr Ile Gly Asn Leu Val Arg Gly Ser Lys Leu Leu Cys Glu Thr
    2130                2135                2140                
Ser Leu Gly Tyr Lys Met Asp Asp Leu Leu Thr Ser Tyr Ile Ser Gln
2145                2150                2155                2160
Met Leu Thr Ala Met Ser Lys Gln Arg Gly Ser Arg Ser Gly Lys
                2165                2170                2175


<210> 1202
<211> 469
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 55, 74
<223> Xaa = Any Amino Acid

<400> 1202
Met Ile Thr Glu Gly Ala Gln Ala Pro Arg Leu Leu Leu Pro Pro Leu
 1               5                  10                  15      
Leu Leu Leu Leu Thr Leu Pro Ala Thr Gly Ser Asp Pro Val Leu Cys
            20                  25                  30          
Phe Thr Gln Tyr Glu Glu Ser Ser Gly Lys Cys Lys Gly Leu Leu Gly
        35                  40                  45              
Gly Gly Val Ser Val Glu Xaa Cys Cys Leu Asn Thr Ala Phe Ala Tyr
    50                  55                  60                  
Gln Lys Arg Ser Gly Gly Leu Cys Gln Xaa Cys Arg Ser Pro Arg Trp
65                  70                  75                  80  
Ser Leu Trp Ser Thr Trp Ala Pro Cys Ser Val Thr Cys Ser Glu Gly
                85                  90                  95      
Ser Gln Leu Trp Tyr Arg Arg Cys Val Gly Trp Asn Gly Gln Cys Ser
            100                 105                 110         
Gly Lys Val Ala Pro Gly Thr Leu Glu Trp Gln Leu Gln Ala Cys Glu
        115                 120                 125             
Asp Gln Gln Cys Cys Pro Glu Met Gly Gly Trp Ser Gly Trp Gly Pro
    130                 135                 140                 
Trp Glu Pro Cys Ser Val Thr Cys Ser Lys Gly Thr Arg Thr Arg Arg
145                 150                 155                 160 
Arg Ala Cys Asn His Pro Ala Pro Lys Cys Gly Gly His Cys Pro Gly
                165                 170                 175     
Gln Ala Gln Glu Ser Glu Ala Cys Asp Thr Gln Gln Val Cys Pro Thr
            180                 185                 190         
His Gly Ala Trp Ala Thr Trp Gly Pro Trp Thr Pro Cys Ser Ala Ser
        195                 200                 205             
Cys His Gly Gly Pro His Glu Pro Lys Glu Thr Arg Ser Arg Lys Cys
    210                 215                 220                 
Ser Ala Pro Glu Pro Ser Gln Lys Pro Pro Gly Lys Pro Cys Pro Gly
225                 230                 235                 240 
Leu Ala Tyr Glu Gln Arg Arg Cys Thr Gly Leu Pro Pro Cys Pro Val
                245                 250                 255     
Ala Gly Gly Trp Gly Pro Trp Gly Pro Val Ser Pro Cys Pro Val Thr
            260                 265                 270         
Cys Gly Leu Gly Gln Thr Met Glu Gln Arg Thr Cys Asn His Pro Val
        275                 280                 285             
Pro Gln His Gly Gly Pro Phe Cys Ala Gly Asp Ala Thr Arg Thr His
    290                 295                 300                 
Ile Cys Asn Thr Ala Val Pro Cys Pro Val Asp Gly Glu Trp Asp Ser
305                 310                 315                 320 
Trp Gly Glu Trp Ser Pro Cys Ile Arg Arg Asn Met Lys Ser Ile Ser
                325                 330                 335     
Cys Gln Glu Ile Pro Gly Gln Gln Ser Arg Gly Arg Thr Cys Arg Gly
            340                 345                 350         
Arg Lys Phe Asp Gly His Arg Cys Ala Gly Gln Gln Gln Asp Ile Arg
        355                 360                 365             
His Cys Tyr Ser Ile Gln His Cys Pro Leu Lys Gly Ser Trp Ser Glu
    370                 375                 380                 
Trp Ser Thr Trp Gly Leu Cys Met Pro Pro Cys Gly Pro Asn Pro Thr
385                 390                 395                 400 
Arg Ala Arg Gln Arg Leu Cys Thr Pro Leu Leu Pro Lys Tyr Pro Pro
                405                 410                 415     
Thr Val Ser Met Val Glu Gly Gln Gly Glu Lys Asn Val Thr Phe Trp
            420                 425                 430         
Gly Arg Pro Leu Pro Arg Cys Glu Glu Leu Gln Gly Gln Lys Leu Val
        435                 440                 445             
Val Glu Glu Lys Arg Pro Cys Leu His Val Pro Ala Cys Lys Asp Pro
    450                 455                 460                 
Glu Glu Glu Glu Leu
465                 


<210> 1203
<211> 414
<212> PRT
<213> Homo sapiens

<400> 1203
Met Ser Lys Lys Ile Ser Gly Gly Ser Val Val Glu Met Gln Gly Asp
 1               5                  10                  15      
Glu Met Thr Arg Ile Ile Trp Glu Leu Ile Lys Glu Lys Leu Ile Ile
            20                  25                  30          
Pro Tyr Val Glu Leu Asp Leu His Ser Tyr Asp Leu Gly Ile Glu Asn
        35                  40                  45              
Arg Asp Ala Thr Asn Asp Gln Val Thr Lys Asp Ala Ala Glu Ala Ile
    50                  55                  60                  
Lys Lys His Asn Val Gly Val Lys Cys Ala Thr Ile Thr Pro Asp Glu
65                  70                  75                  80  
Lys Arg Val Glu Glu Phe Lys Leu Lys Gln Met Trp Lys Ser Pro Asn
                85                  90                  95      
Gly Thr Ile Arg Asn Ile Leu Gly Gly Thr Val Phe Arg Glu Ala Ile
            100                 105                 110         
Ile Cys Lys Asn Ile Pro Arg Leu Val Ser Gly Trp Val Glu Pro Ile
        115                 120                 125             
Ile Ile Gly Arg His Ala Tyr Gly Asp Gln Tyr Arg Ala Thr Asp Phe
    130                 135                 140                 
Val Val Pro Gly Pro Gly Lys Val Glu Ile Thr Tyr Thr Pro Ser Asp
145                 150                 155                 160 
Gly Thr Gln Lys Val Thr Tyr Leu Val His Asn Phe Glu Glu Gly Gly
                165                 170                 175     
Gly Val Ala Met Gly Met Tyr Asn Gln Asp Lys Ser Ile Glu Asp Phe
            180                 185                 190         
Ala His Ser Ser Phe Gln Met Ala Leu Ser Lys Gly Trp Pro Leu Tyr
        195                 200                 205             
Leu Ser Thr Lys Asn Thr Ile Leu Lys Lys Tyr Asp Gly Arg Phe Lys
    210                 215                 220                 
Asp Ile Phe Gln Glu Ile Tyr Asp Lys Gln Tyr Lys Ser Gln Phe Glu
225                 230                 235                 240 
Ala Gln Lys Ile Trp Tyr Glu His Arg Leu Ile Asp Asp Met Val Ala
                245                 250                 255     
Gln Ala Met Lys Ser Glu Gly Gly Phe Ile Trp Ala Cys Lys Asn Tyr
            260                 265                 270         
Asp Gly Asp Val Gln Ser Asp Ser Val Ala Gln Gly Tyr Gly Ser Leu
        275                 280                 285             
Gly Met Met Thr Ser Val Leu Val Cys Pro Asp Gly Lys Thr Val Glu
    290                 295                 300                 
Ala Glu Ala Ala His Gly Thr Val Thr Arg His Tyr Arg Met Tyr Gln
305                 310                 315                 320 
Lys Gly Gln Glu Thr Ser Thr Asn Pro Ile Ala Ser Ile Phe Ala Trp
                325                 330                 335     
Thr Arg Gly Leu Ala His Arg Ala Lys Leu Asp Asn Asn Lys Glu Leu
            340                 345                 350         
Ala Phe Phe Ala Asn Ala Leu Glu Glu Val Ser Ile Glu Thr Ile Glu
        355                 360                 365             
Ala Gly Phe Met Thr Lys Asp Leu Ala Ala Cys Ile Lys Gly Leu Pro
    370                 375                 380                 
Asn Val Gln Arg Ser Asp Tyr Leu Asn Thr Phe Glu Phe Met Asp Lys
385                 390                 395                 400 
Leu Gly Glu Asn Leu Lys Ile Lys Leu Ala Gln Ala Lys Leu
                405                 410                 


<210> 1204
<211> 1582
<212> PRT
<213> Homo sapiens

<400> 1204
Met Gly Ser Lys Arg Arg Arg Ala Thr Ser Pro Ser Ser Ser Val Ser
 1               5                  10                  15      
Gly Asp Phe Asp Asp Gly His His Ser Val Ser Thr Pro Gly Pro Ser
            20                  25                  30          
Arg Lys Arg Arg Arg Leu Ser Asn Leu Pro Thr Val Asp Pro Ile Ala
        35                  40                  45              
Val Cys His Glu Leu Tyr Asn Thr Ile Arg Asp Tyr Lys Asp Glu Gln
    50                  55                  60                  
Gly Arg Leu Leu Cys Glu Leu Phe Ile Arg Ala Pro Lys Arg Arg Asn
65                  70                  75                  80  
Gln Pro Asp Tyr Tyr Glu Val Val Ser Gln Pro Ile Asp Leu Met Lys
                85                  90                  95      
Ile Gln Gln Lys Leu Lys Met Glu Glu Tyr Asp Asp Val Asn Leu Leu
            100                 105                 110         
Thr Ala Asp Phe Gln Leu Leu Phe Asn Asn Ala Lys Ser Tyr Tyr Lys
        115                 120                 125             
Pro Asp Ser Pro Glu Tyr Lys Ala Ala Cys Lys Leu Trp Asp Leu Tyr
    130                 135                 140                 
Leu Arg Thr Arg Asn Glu Phe Val Gln Lys Gly Glu Ala Asp Asp Glu
145                 150                 155                 160 
Asp Asp Asp Glu Asp Gly Gln Asp Asn Gln Gly Thr Val Thr Glu Gly
                165                 170                 175     
Ser Ser Pro Ala Tyr Leu Lys Glu Ile Leu Glu Gln Leu Leu Glu Ala
            180                 185                 190         
Ile Val Val Ala Thr Asn Pro Ser Gly Arg Leu Ile Ser Glu Leu Phe
        195                 200                 205             
Gln Lys Leu Pro Ser Lys Val Gln Tyr Pro Asp Tyr Tyr Ala Ile Ile
    210                 215                 220                 
Lys Glu Pro Ile Asp Leu Lys Thr Ile Ala Gln Arg Ile Gln Asn Gly
225                 230                 235                 240 
Ser Tyr Lys Ser Ile His Ala Met Ala Lys Asp Ile Asp Leu Leu Ala
                245                 250                 255     
Lys Asn Ala Lys Thr Tyr Asn Glu Pro Gly Ser Gln Val Phe Lys Asp
            260                 265                 270         
Ala Asn Ser Ile Lys Lys Ile Phe Tyr Met Lys Lys Ala Glu Ile Glu
        275                 280                 285             
His His Glu Met Ala Lys Ser Ser Leu Arg Met Arg Thr Pro Ser Asn
    290                 295                 300                 
Leu Ala Ala Ala Arg Leu Thr Gly Pro Ser His Ser Lys Gly Ser Leu
305                 310                 315                 320 
Gly Glu Glu Arg Asn Pro Thr Ser Lys Tyr Tyr Arg Asn Lys Arg Ala
                325                 330                 335     
Val Gln Gly Gly Arg Leu Ser Ala Ile Thr Met Ala Leu Gln Tyr Gly
            340                 345                 350         
Ser Glu Ser Glu Glu Asp Ala Ala Leu Ala Ala Ala Arg Tyr Glu Glu
        355                 360                 365             
Gly Glu Ser Glu Ala Glu Ser Ile Thr Ser Phe Met Asp Val Ser Asn
    370                 375                 380                 
Pro Phe Tyr Gln Leu Tyr Asp Thr Val Arg Ser Cys Arg Asn Asn Gln
385                 390                 395                 400 
Gly Gln Leu Ile Ala Glu Pro Phe Tyr His Leu Pro Ser Lys Lys Lys
                405                 410                 415     
Tyr Pro Asp Tyr Tyr Gln Gln Ile Lys Met Pro Ile Ser Leu Gln Gln
            420                 425                 430         
Ile Arg Thr Lys Leu Lys Asn Gln Glu Tyr Glu Thr Leu Asp His Leu
        435                 440                 445             
Glu Cys Asp Leu Asn Leu Met Phe Glu Asn Ala Lys Arg Tyr Asn Val
    450                 455                 460                 
Pro Asn Ser Ala Ile Tyr Lys Arg Val Leu Lys Leu Gln Gln Val Met
465                 470                 475                 480 
Gln Ala Lys Lys Lys Glu Leu Ala Arg Arg Asp Asp Ile Glu Asp Gly
                485                 490                 495     
Asp Ser Met Ile Ser Ser Ala Thr Ser Asp Thr Gly Ser Ala Lys Arg
            500                 505                 510         
Lys Ser Lys Lys Asn Ile Arg Lys Gln Arg Met Lys Ile Leu Phe Asn
        515                 520                 525             
Val Val Leu Glu Ala Arg Glu Pro Gly Ser Gly Arg Arg Leu Cys Asp
    530                 535                 540                 
Leu Phe Met Val Lys Pro Ser Lys Arg Asp Tyr Pro Asp Tyr Tyr Lys
545                 550                 555                 560 
Ile Ile Leu Glu Pro Met Asp Leu Lys Ile Ile Glu His Asn Ile Arg
                565                 570                 575     
Asn Asp Lys Tyr Ala Gly Glu Glu Gly Met Ile Glu Asp Met Lys Leu
            580                 585                 590         
Met Phe Arg Asn Ala Arg His Tyr Asn Glu Glu Gly Ser Gln Val Tyr
        595                 600                 605             
Asn Asp Ala His Ile Leu Glu Lys Leu Leu Lys Glu Lys Arg Lys Glu
    610                 615                 620                 
Leu Gly Pro Leu Pro Asp Asp Asp Asp Met Ala Ser Pro Lys Leu Lys
625                 630                 635                 640 
Leu Ser Arg Lys Ser Gly Ile Ser Pro Lys Lys Ser Lys Tyr Met Thr
                645                 650                 655     
Pro Met Gln Gln Lys Leu Asn Glu Val Tyr Glu Ala Val Lys Asn Tyr
            660                 665                 670         
Thr Asp Lys Arg Gly Arg Arg Leu Ser Ala Ile Phe Leu Arg Leu Pro
        675                 680                 685             
Ser Arg Ser Glu Leu Pro Asp Tyr Tyr Leu Thr Ile Lys Lys Pro Met
    690                 695                 700                 
Asp Met Glu Lys Ile Arg Ser His Met Met Ala Asn Lys Tyr Gln Asp
705                 710                 715                 720 
Ile Asp Ser Met Val Glu Asp Phe Val Met Met Phe Asn Asn Ala Cys
                725                 730                 735     
Thr Tyr Asn Glu Pro Glu Ser Leu Ile Tyr Lys Asp Ala Leu Val Leu
            740                 745                 750         
His Lys Val Leu Leu Glu Thr Arg Arg Asp Leu Glu Gly Asp Glu Asp
        755                 760                 765             
Ser His Val Pro Asn Val Thr Leu Leu Ile Gln Glu Leu Ile His Asn
    770                 775                 780                 
Leu Phe Val Ser Val Met Ser His Gln Asp Asp Glu Gly Arg Cys Tyr
785                 790                 795                 800 
Ser Asp Ser Leu Ala Glu Ile Pro Ala Val Asp Pro Asn Phe Pro Asn
                805                 810                 815     
Lys Pro Pro Leu Thr Phe Asp Ile Ile Arg Lys Asn Val Glu Asn Asn
            820                 825                 830         
Arg Tyr Arg Arg Leu Asp Leu Phe Gln Glu His Met Phe Glu Val Leu
        835                 840                 845             
Glu Arg Ala Arg Arg Met Asn Arg Thr Asp Ser Glu Ile Tyr Glu Asp
    850                 855                 860                 
Ala Val Glu Leu Gln Gln Phe Phe Ile Lys Ile Arg Asp Glu Leu Cys
865                 870                 875                 880 
Lys Asn Gly Glu Ile Leu Leu Ser Pro Ala Leu Ser Tyr Thr Thr Lys
                885                 890                 895     
His Leu His Asn Asp Val Glu Lys Glu Arg Lys Glu Lys Leu Pro Lys
            900                 905                 910         
Glu Ile Glu Glu Asp Lys Leu Lys Arg Glu Glu Glu Lys Arg Glu Ala
        915                 920                 925             
Glu Lys Ser Glu Asp Ser Ser Gly Ala Ala Gly Leu Ser Gly Leu His
    930                 935                 940                 
Arg Thr Tyr Ser Gln Asp Cys Ser Phe Lys Asn Ser Met Tyr His Val
945                 950                 955                 960 
Gly Asp Tyr Val Tyr Val Glu Pro Ala Glu Ala Asn Leu Gln Pro His
                965                 970                 975     
Ile Val Cys Ile Glu Arg Leu Trp Glu Asp Ser Ala Glu Lys Glu Val
            980                 985                 990         
Phe Lys Ser Asp Tyr Tyr Asn Lys Val Pro Val Ser Lys Ile Leu Gly
        995                 1000                1005            
Lys Cys Val Val Met Phe Val Lys Glu Tyr Phe Lys Leu Cys Pro Glu
    1010                1015                1020                
Asn Phe Arg Asp Glu Asp Val Phe Val Cys Glu Ser Arg Tyr Ser Ala
1025                1030                1035                1040
Lys Thr Lys Ser Phe Lys Lys Ile Lys Leu Trp Thr Met Pro Ile Ser
                1045                1050                1055    
Ser Val Arg Phe Val Pro Arg Asp Val Pro Leu Pro Val Val Arg Val
            1060                1065                1070        
Ala Ser Val Phe Ala Asn Ala Asp Lys Gly Asp Asp Glu Lys Asn Thr
        1075                1080                1085            
Asp Asn Ser Glu Asp Ser Arg Ala Glu Asp Asn Phe Asn Leu Glu Lys
    1090                1095                1100                
Glu Lys Glu Asp Val Pro Val Glu Met Ser Asn Gly Glu Pro Val Cys
1105                1110                1115                1120
His Tyr Phe Glu Gln Leu His Tyr Asn Asp Met Trp Leu Lys Val Gly
                1125                1130                1135    
Asp Cys Val Phe Ile Lys Ser His Gly Leu Val Arg Pro Arg Val Gly
            1140                1145                1150        
Arg Ile Glu Lys Val Trp Val Arg Asp Gly Ala Ala Tyr Phe Tyr Gly
        1155                1160                1165            
Pro Ile Phe Ile His Pro Glu Glu Thr Glu His Glu Pro Thr Lys Met
    1170                1175                1180                
Phe Tyr Lys Lys Glu Val Phe Leu Ser Asn Leu Glu Glu Thr Cys Pro
1185                1190                1195                1200
Met Thr Cys Ile Leu Gly Lys Cys Ala Val Leu Ser Phe Lys Asp Phe
                1205                1210                1215    
Leu Ser Cys Lys Pro Thr Glu Ile Pro Glu Asn Asp Ile Leu Leu Cys
            1220                1225                1230        
Glu Ser Arg Tyr Asn Glu Ser Asp Lys Gln Met Lys Lys Phe Lys Gly
        1235                1240                1245            
Leu Lys Arg Phe Ser Leu Ser Ala Lys Val Val Asp Asp Glu Ile Tyr
    1250                1255                1260                
Tyr Phe Arg Lys Pro Ile Val Pro Gln Lys Glu Pro Ser Pro Leu Leu
1265                1270                1275                1280
Gly Lys Lys Ile Gln Leu Leu Glu Ala Lys Phe Ala Glu Leu Glu Gly
                1285                1290                1295    
Gly Asp Asp Asp Ile Glu Glu Met Gly Glu Glu Asp Ser Glu Ser Thr
            1300                1305                1310        
Pro Lys Ser Ala Lys Gly Ser Ala Lys Lys Glu Gly Ser Lys Arg Lys
        1315                1320                1325            
Ile Asn Met Ser Gly Tyr Ile Leu Phe Ser Ser Glu Met Arg Ala Val
    1330                1335                1340                
Ile Lys Ala Gln His Pro Asp Tyr Ser Phe Gly Glu Leu Ser Arg Leu
1345                1350                1355                1360
Val Gly Thr Glu Trp Arg Asn Leu Glu Thr Ala Lys Lys Ala Glu Tyr
                1365                1370                1375    
Glu Gly Met Met Gly Gly Tyr Pro Pro Gly Leu Pro Pro Leu Gln Gly
            1380                1385                1390        
Pro Val Asp Gly Leu Val Ser Met Gly Ser Met Gln Pro Leu His Pro
        1395                1400                1405            
Gly Gly Pro Pro Pro His His Leu Pro Pro Gly Val Pro Gly Leu Pro
    1410                1415                1420                
Gly Ile Pro Pro Pro Gly Val Met Asn Gln Gly Val Ala Pro Met Val
1425                1430                1435                1440
Gly Thr Pro Ala Pro Gly Gly Ser Pro Tyr Gly Gln Gln Val Gly Val
                1445                1450                1455    
Leu Gly Pro Pro Arg Gln Gln Ala Pro Pro Pro Tyr Pro Gly Pro His
            1460                1465                1470        
Pro Ala Gly Pro Pro Val Ile Gln Gln Pro Thr Thr Pro Met Phe Val
        1475                1480                1485            
Ala Pro Pro Pro Lys Thr Gln Arg Leu Leu His Ser Glu Ala Tyr Leu
    1490                1495                1500                
Lys Tyr Ile Glu Gly Leu Ser Ala Glu Ser Asn Ser Ile Ser Lys Trp
1505                1510                1515                1520
Asp Gln Thr Leu Ala Ala Arg Arg Arg Asp Val His Leu Ser Lys Glu
                1525                1530                1535    
Gln Glu Ser Arg Leu Pro Ser His Trp Leu Lys Ser Lys Gly Ala His
            1540                1545                1550        
Thr Thr Met Ala Asp Ala Leu Trp Arg Leu Arg Asp Leu Met Leu Arg
        1555                1560                1565            
Asp Thr Leu Asn Ile Arg Gln Ala Tyr Asn Leu Glu Asn Val
    1570                1575                1580        


<210> 1205
<211> 795
<212> PRT
<213> Homo sapiens

<400> 1205
Met Glu Lys Gln Lys Pro Phe Ala Leu Phe Val Pro Pro Arg Ser Ser
 1               5                  10                  15      
Ser Ser Gln Val Ser Ala Val Lys Pro Gln Thr Leu Gly Gly Asp Ser
            20                  25                  30          
Thr Phe Phe Lys Ser Phe Asn Lys Cys Thr Glu Asp Asp Phe Glu Phe
        35                  40                  45              
Pro Phe Ala Lys Thr Asn Leu Ser Lys Asn Gly Glu Asn Ile Asp Ser
    50                  55                  60                  
Asp Pro Ala Leu Gln Lys Val Asn Phe Leu Pro Val Leu Glu Gln Val
65                  70                  75                  80  
Gly Asn Ser Asp Cys His Tyr Gln Glu Gly Leu Lys Asp Ser Asp Leu
                85                  90                  95      
Glu Asn Ser Glu Gly Leu Ser Arg Val Tyr Ser Lys Leu Tyr Lys Glu
            100                 105                 110         
Ala Glu Lys Ile Lys Lys Trp Lys Val Ser Thr Glu Ala Glu Leu Arg
        115                 120                 125             
Gln Lys Glu Ser Lys Leu Gln Glu Asn Arg Lys Ile Ile Glu Ala Gln
    130                 135                 140                 
Arg Lys Ala Ile Gln Glu Leu Gln Phe Gly Asn Glu Lys Val Ser Leu
145                 150                 155                 160 
Lys Leu Glu Glu Gly Ile Gln Glu Asn Lys Asp Leu Ile Lys Glu Asn
                165                 170                 175     
Asn Ala Thr Arg His Leu Cys Asn Leu Leu Lys Glu Thr Cys Ala Arg
            180                 185                 190         
Ser Ala Glu Lys Thr Lys Lys Tyr Glu Tyr Glu Arg Glu Glu Thr Arg
        195                 200                 205             
Gln Val Tyr Met Asp Leu Asn Asn Asn Ile Glu Lys Met Ile Thr Ala
    210                 215                 220                 
Phe Glu Glu Leu Arg Val Gln Ala Glu Asn Ser Arg Leu Glu Met His
225                 230                 235                 240 
Phe Lys Leu Lys Glu Asp Tyr Glu Lys Ile Gln His Leu Glu Gln Glu
                245                 250                 255     
Tyr Lys Lys Glu Ile Asn Asp Lys Glu Lys Gln Val Ser Leu Leu Leu
            260                 265                 270         
Ile Gln Ile Thr Glu Lys Glu Asn Lys Met Lys Asp Leu Thr Phe Leu
        275                 280                 285             
Leu Glu Glu Ser Arg Asp Lys Val Asn Gln Leu Glu Glu Lys Thr Lys
    290                 295                 300                 
Leu Gln Ser Glu Asn Leu Lys Gln Ser Ile Glu Lys Gln His His Leu
305                 310                 315                 320 
Thr Lys Glu Leu Glu Asp Ile Lys Val Ser Leu Gln Arg Ser Val Ser
                325                 330                 335     
Thr Gln Lys Ala Leu Glu Glu Asp Leu Gln Ile Ala Thr Lys Thr Ile
            340                 345                 350         
Cys Gln Leu Thr Glu Glu Lys Glu Thr Gln Met Glu Glu Ser Asn Lys
        355                 360                 365             
Ala Arg Ala Ala His Ser Phe Val Val Thr Glu Phe Glu Thr Thr Val
    370                 375                 380                 
Cys Ser Leu Glu Glu Leu Leu Arg Thr Glu Gln Gln Arg Leu Glu Lys
385                 390                 395                 400 
Asn Glu Asp Gln Leu Lys Ile Leu Thr Met Glu Leu Gln Lys Lys Ser
                405                 410                 415     
Ser Glu Leu Glu Glu Met Thr Lys Leu Thr Asn Asn Lys Glu Val Glu
            420                 425                 430         
Leu Glu Glu Leu Lys Lys Val Leu Gly Glu Lys Glu Thr Leu Leu Tyr
        435                 440                 445             
Glu Asn Lys Gln Phe Glu Lys Ile Ala Glu Glu Leu Lys Gly Thr Glu
    450                 455                 460                 
Gln Glu Leu Ile Gly Leu Leu Gln Ala Arg Glu Lys Glu Val His Asp
465                 470                 475                 480 
Leu Glu Ile Gln Leu Thr Ala Ile Thr Thr Ser Glu Gln Tyr Tyr Ser
                485                 490                 495     
Lys Glu Val Lys Asp Leu Lys Thr Glu Leu Glu Asn Glu Lys Leu Lys
            500                 505                 510         
Asn Thr Glu Leu Thr Ser His Cys Asn Lys Leu Ser Leu Glu Asn Lys
        515                 520                 525             
Glu Leu Thr Gln Glu Thr Ser Asp Met Thr Leu Glu Leu Lys Asn Gln
    530                 535                 540                 
Gln Glu Asp Ile Asn Asn Asn Lys Lys Gln Glu Glu Arg Met Leu Lys
545                 550                 555                 560 
Gln Ile Glu Asn Leu Gln Glu Thr Glu Thr Gln Leu Arg Asn Glu Leu
                565                 570                 575     
Glu Tyr Val Arg Glu Glu Leu Lys Gln Lys Arg Asp Glu Val Lys Cys
            580                 585                 590         
Lys Leu Asp Lys Ser Glu Glu Asn Cys Asn Asn Leu Arg Lys Gln Val
        595                 600                 605             
Glu Asn Lys Asn Lys Tyr Ile Glu Glu Leu Gln Gln Glu Asn Lys Ala
    610                 615                 620                 
Leu Lys Lys Lys Gly Thr Ala Glu Ser Lys Gln Leu Asn Val Tyr Glu
625                 630                 635                 640 
Ile Lys Val Asn Lys Leu Glu Leu Glu Leu Glu Ser Ala Lys Gln Lys
                645                 650                 655     
Phe Gly Glu Ile Thr Asp Thr Tyr Gln Lys Glu Ile Glu Asp Lys Lys
            660                 665                 670         
Ile Ser Glu Glu Asn Leu Leu Glu Glu Val Glu Lys Ala Lys Val Ile
        675                 680                 685             
Ala Asp Glu Ala Val Lys Leu Gln Lys Glu Ile Asp Lys Arg Cys Gln
    690                 695                 700                 
His Lys Ile Ala Glu Met Val Ala Leu Met Glu Lys His Lys His Gln
705                 710                 715                 720 
Tyr Asp Lys Ile Ile Glu Glu Arg Asp Ser Glu Leu Gly Leu Tyr Lys
                725                 730                 735     
Ser Lys Glu Gln Glu Gln Ser Ser Leu Arg Ala Ser Leu Glu Ile Glu
            740                 745                 750         
Leu Ser Asn Leu Lys Ala Glu Leu Leu Ser Val Lys Lys Gln Leu Glu
        755                 760                 765             
Ile Glu Arg Glu Glu Lys Glu Lys Leu Lys Arg Glu Ala Lys Glu Asn
    770                 775                 780                 
Thr Ala Thr Leu Lys Glu Lys Lys Lys Lys Lys
785                 790                 795 


<210> 1206
<211> 1035
<212> PRT
<213> Homo sapiens

<400> 1206
Met Phe Pro Tyr Asp Ser Arg Leu Asp Asp Lys Lys Phe Leu Tyr Ser
 1               5                  10                  15      
Ala Pro Arg Asn Lys Ser His Ile Asp Thr Cys Leu His Ala Tyr Ile
            20                  25                  30          
Phe Arg Pro Glu Val Tyr Gln Leu Pro Ile Cys Lys Leu Lys Glu Leu
        35                  40                  45              
Phe Glu Glu Asn Arg Lys Leu Gln Gln Phe Ser Pro Leu Ser Asp Tyr
    50                  55                  60                  
Glu Gly Gln Glu Glu Glu Met Asn Gly Thr Lys Met Lys Phe Gly Lys
65                  70                  75                  80  
Arg Asn Asn Ser Arg Gly Glu Ala Ile Ile Ser Gly Lys Gln Arg Ser
                85                  90                  95      
Ser His Ser Leu Asp Tyr Asp Lys Asp Arg Val Lys Glu Leu Ile Asn
            100                 105                 110         
Leu Ile Gln Cys Arg Lys Lys Ser Val Gly Gly Asp Ser Asp Thr Glu
        115                 120                 125             
Asp Met Arg Ser Lys Thr Val Leu Lys Arg Lys Leu Glu Asp Leu Pro
    130                 135                 140                 
Glu Asn Met Arg Lys Leu Ala Lys Thr Ser Asn Leu Ser Glu Asn Cys
145                 150                 155                 160 
His Leu Tyr Glu Glu Ser Pro Gln Pro Ile Gly Ser Leu Gly His Asp
                165                 170                 175     
Ala Asp Leu Arg Arg Gln Gln Gln Asp Thr Cys Asn Ser Gly Ile Ala
            180                 185                 190         
Asp Ile His Arg Leu Phe Asn Trp Leu Ser Glu Thr Leu Ala Asn Ala
        195                 200                 205             
Arg His Ser Asp Ala Ser Leu Thr Asp Thr Val Asn Lys Ala Leu Gly
    210                 215                 220                 
Leu Ser Thr Asp Asp Ala Tyr Glu Glu Leu Arg Gln Lys His Glu Tyr
225                 230                 235                 240 
Glu Leu Asn Ser Thr Pro Asp Lys Lys Asp Tyr Glu Gln Pro Thr Cys
                245                 250                 255     
Ala Lys Val Glu Asn Ala Gln Phe Lys Gly Thr Gln Ser Leu Leu Leu
            260                 265                 270         
Glu Val Asp Ala Thr Ser Lys Tyr Ser Val Ala Ile Ser Thr Ser Glu
        275                 280                 285             
Val Gly Thr Asp His Lys Leu His Leu Lys Glu Asp Pro Asn Leu Ile
    290                 295                 300                 
Ser Val Asn Asn Phe Glu Asp Cys Ser Leu Cys Pro Ser Val Pro Ile
305                 310                 315                 320 
Glu His Gly Phe Arg Arg Gln Gln Ser Lys Ser Asn Asn Val Glu Glu
                325                 330                 335     
Thr Glu Ile His Trp Lys Leu Ile Pro Ile Thr Asp Thr Leu Lys Gly
            340                 345                 350         
Thr Thr Glu Asp Asp Val Leu Thr Gly Gln Val Glu Glu Gln Cys Val
        355                 360                 365             
Pro Ala Ala Glu Ala Glu Pro Pro Ala Val Ser Glu Thr Thr Glu Arg
    370                 375                 380                 
Thr Val Leu Gly Glu Tyr Asn Leu Phe Ser Arg Lys Ile Glu Glu Ile
385                 390                 395                 400 
Leu Lys Gln Lys Asn Val Ser Tyr Val Ser Arg Val Ser Thr Pro Ile
                405                 410                 415     
Phe Ser Thr Gln Glu Lys Met Lys Arg Leu Ser Glu Phe Ile Tyr Ser
            420                 425                 430         
Lys Thr Ser Lys Ala Gly Val Gln Glu Phe Val Asp Gly Leu His Glu
        435                 440                 445             
Lys Leu Asn Thr Ile Ile Ile Lys Ala Ser Ala Lys Gly Gly Asn Leu
    450                 455                 460                 
Pro Pro Val Ser Pro Asn Asp Ser Gly Ala Lys Ile Ala Ser Asn Pro
465                 470                 475                 480 
Leu Glu Arg His Val Ile Pro Val Ser Ser Ser Asp Phe Asn Asn Lys
                485                 490                 495     
His Leu Leu Glu Pro Leu Cys Ser Asp Pro Leu Lys Asp Thr Asn Ser
            500                 505                 510         
Asp Glu Gln His Ser Thr Ser Ala Leu Thr Glu Val Glu Met Asn Gln
        515                 520                 525             
Pro Gln His Ala Thr Glu Leu Met Val Thr Ser Asp His Ile Val Pro
    530                 535                 540                 
Gly Asp Met Ala Arg Glu Pro Val Glu Glu Thr Thr Lys Ser Pro Ser
545                 550                 555                 560 
Asp Val Asn Ile Ser Ala Gln Pro Ala Leu Ser Asn Phe Ile Ser Gln
                565                 570                 575     
Leu Glu Pro Glu Val Phe Asn Ser Leu Val Lys Ile Met Lys Asp Val
            580                 585                 590         
Gln Lys Asn Thr Val Lys Phe Tyr Ile His Glu Glu Glu Glu Ser Val
        595                 600                 605             
Leu Cys Lys Glu Ile Lys Glu Tyr Leu Ile Lys Leu Gly Asn Thr Glu
    610                 615                 620                 
Cys His Pro Glu Gln Phe Leu Glu Arg Arg Ser Lys Leu Asp Lys Leu
625                 630                 635                 640 
Leu Ile Ile Ile Gln Asn Glu Asp Ile Ala Gly Phe Ile His Lys Ile
                645                 650                 655     
Pro Gly Leu Val Thr Leu Lys Lys Leu Pro Cys Val Ser Phe Ala Gly
            660                 665                 670         
Val Asp Ser Leu Asp Asp Val Lys Asn His Thr Tyr Asn Glu Leu Phe
        675                 680                 685             
Val Ser Gly Gly Phe Ile Val Ser Asp Glu Ser Ile Leu Asn Pro Glu
    690                 695                 700                 
Val Val Thr Val Glu Asn Leu Lys Asn Phe Leu Thr Phe Leu Glu Glu
705                 710                 715                 720 
Leu Ser Thr Pro Glu Gly Lys Trp Gln Trp Lys Val His Cys Lys Phe
                725                 730                 735     
Gln Lys Lys Leu Lys Glu Leu Gly Arg Leu Asn Ala Lys Ala Leu Ser
            740                 745                 750         
Leu Leu Thr Leu Leu Asn Val Tyr Gln Lys Lys His Leu Val Glu Ile
        755                 760                 765             
Leu Ser Tyr His Asn Cys Asp Ser Gln Thr Arg Asn Ala Pro Glu Leu
    770                 775                 780                 
Asp Cys Leu Ile Arg Leu Gln Ala Gln Asn Ile Gln Gln Arg His Val
785                 790                 795                 800 
Val Phe Leu Thr Glu Lys Asn Ile Lys Met Leu Ser Ser Tyr Thr Asp
                805                 810                 815     
Asn Gly Ile Val Val Ala Thr Ala Glu Asp Phe Met Gln Asn Phe Lys
            820                 825                 830         
Asn Leu Val Gly Tyr His Asn Ser Ile Thr Glu Glu Asn Leu Pro Gln
        835                 840                 845             
Leu Gly Ala Asn Glu Asn Leu Glu Ser Gln Ser Ala Leu Leu Glu Asn
    850                 855                 860                 
Asp Glu Lys Asp Glu Glu Asp Met Ser Leu Asp Ser Gly Asp Glu Ile
865                 870                 875                 880 
Ser His Ile Glu Val Cys Ser Asn Phe His Ser Glu Ile Trp Glu Lys
                885                 890                 895     
Glu Thr Lys Gly Ser Arg Gly Thr Asp Gln Lys Lys Asn Thr Gln Ile
            900                 905                 910         
Glu Leu Gln Ser Ser Pro Asp Val Gln Asn Ser Leu Leu Glu Asp Lys
        915                 920                 925             
Thr Tyr Leu Asp Ser Glu Glu Arg Thr Ser Ile Asp Ile Val Cys Ser
    930                 935                 940                 
Glu Gly Glu Asn Ser Asn Ser Thr Glu Gln Asp Ser Tyr Ser Asn Phe
945                 950                 955                 960 
Gln Val Tyr His Ser Gln Leu Asn Met Ser His Gln Phe Ser His Phe
                965                 970                 975     
Asn Val Leu Thr His Gln Thr Phe Leu Gly Thr Pro Tyr Ala Leu Ser
            980                 985                 990         
Ser Ser Gln Ser Gln Glu Asn Glu Asn Tyr Phe Leu Ser Ala Tyr Thr
        995                 1000                1005            
Glu Ser Leu Asp Arg Asp Lys Ser Pro Pro Pro Leu Ser Trp Gly Lys
    1010                1015                1020                
Ser Asp Ser Ser Arg Pro Tyr Ser Gln Glu Lys
1025                1030                1035


<210> 1207
<211> 524
<212> PRT
<213> Homo sapiens

<400> 1207
Met Tyr Ala Leu Phe Leu Leu Ala Ser Leu Leu Gly Ala Ala Leu Ala
 1               5                  10                  15      
Gly Pro Val Leu Gly Leu Lys Glu Cys Thr Arg Gly Ser Ala Val Trp
            20                  25                  30          
Cys Gln Asn Val Lys Thr Ala Ser Asp Cys Gly Ala Val Lys His Cys
        35                  40                  45              
Leu Gln Thr Val Trp Asn Lys Pro Thr Val Lys Ser Leu Pro Cys Asp
    50                  55                  60                  
Ile Cys Lys Asp Val Val Thr Ala Ala Gly Asp Met Leu Lys Asp Asn
65                  70                  75                  80  
Ala Thr Glu Glu Glu Ile Leu Val Tyr Leu Glu Lys Thr Cys Asp Trp
                85                  90                  95      
Leu Pro Lys Pro Asn Met Ser Ala Ser Cys Lys Glu Ile Val Asp Ser
            100                 105                 110         
Tyr Leu Pro Val Ile Leu Asp Ile Ile Lys Gly Glu Met Ser Arg Pro
        115                 120                 125             
Gly Glu Val Cys Ser Ala Leu Asn Leu Cys Glu Ser Leu Gln Lys His
    130                 135                 140                 
Leu Ala Glu Leu Asn His Gln Lys Gln Leu Glu Ser Asn Lys Ile Pro
145                 150                 155                 160 
Glu Leu Asp Met Thr Glu Val Val Ala Pro Phe Met Ala Asn Ile Pro
                165                 170                 175     
Leu Leu Leu Tyr Pro Gln Asp Gly Pro Arg Ser Lys Pro Gln Pro Lys
            180                 185                 190         
Asp Asn Gly Asp Val Cys Gln Asp Cys Ile Gln Met Val Thr Asp Ile
        195                 200                 205             
Gln Thr Ala Val Arg Thr Asn Ser Thr Phe Val Gln Ala Leu Val Glu
    210                 215                 220                 
His Val Lys Glu Glu Cys Asp Arg Leu Gly Pro Gly Met Ala Asp Ile
225                 230                 235                 240 
Cys Lys Asn Tyr Ile Ser Gln Tyr Ser Glu Ile Ala Ile Gln Met Met
                245                 250                 255     
Met His Met Gln Pro Lys Glu Ile Cys Ala Leu Val Gly Phe Cys Asp
            260                 265                 270         
Glu Val Lys Glu Met Pro Met Gln Thr Leu Val Pro Ala Lys Val Ala
        275                 280                 285             
Ser Lys Asn Val Ile Pro Ala Leu Glu Leu Val Glu Pro Ile Lys Lys
    290                 295                 300                 
His Glu Val Pro Ala Lys Ser Asp Val Tyr Cys Glu Val Cys Glu Phe
305                 310                 315                 320 
Leu Val Lys Glu Val Thr Lys Leu Ile Asp Asn Asn Lys Thr Glu Lys
                325                 330                 335     
Glu Ile Leu Asp Ala Phe Asp Lys Met Cys Ser Lys Leu Pro Lys Ser
            340                 345                 350         
Leu Ser Glu Glu Cys Gln Glu Val Val Asp Thr Tyr Gly Ser Ser Ile
        355                 360                 365             
Leu Ser Ile Leu Leu Glu Glu Val Ser Pro Glu Leu Val Cys Ser Met
    370                 375                 380                 
Leu His Leu Cys Ser Gly Thr Arg Leu Pro Ala Leu Thr Val His Val
385                 390                 395                 400 
Thr Gln Pro Lys Asp Gly Gly Phe Cys Glu Val Cys Lys Lys Leu Val
                405                 410                 415     
Gly Tyr Leu Asp Arg Asn Leu Glu Lys Asn Ser Thr Lys Gln Glu Ile
            420                 425                 430         
Leu Ala Ala Leu Glu Lys Gly Cys Ser Phe Leu Pro Asp Pro Tyr Gln
        435                 440                 445             
Lys Gln Cys Asp Gln Phe Val Ala Glu Tyr Glu Pro Val Leu Ile Glu
    450                 455                 460                 
Ile Leu Val Glu Val Met Asp Pro Ser Phe Val Cys Leu Lys Ile Gly
465                 470                 475                 480 
Ala Cys Pro Ser Ala His Lys Pro Leu Leu Gly Thr Glu Lys Cys Ile
                485                 490                 495     
Trp Gly Pro Ser Tyr Trp Cys Gln Asn Thr Glu Thr Ala Ala Gln Cys
            500                 505                 510         
Asn Ala Val Glu His Cys Lys Arg His Val Trp Asn
        515                 520                 


<210> 1208
<211> 248
<212> PRT
<213> Homo sapiens

<400> 1208
Met Ser Val Gly Ile Asp His Leu Ala Leu Asp Glu Ile Lys Lys Arg
 1               5                  10                  15      
Gly Ile Arg Val Gly Tyr Thr Pro Asp Val Leu Thr Arg Tyr His Arg
            20                  25                  30          
Arg Thr Arg Ser Leu Pro Ala Thr Tyr His Leu Pro Pro Val Ala Gly
        35                  40                  45              
Gly His Arg Gly Ser Glu Glu Trp Trp Trp Thr Ser Trp Lys Pro Leu
    50                  55                  60                  
Trp Leu Cys Gly Tyr Gly Leu Thr Gln Ser Thr Val Gly Ile Ile Gly
65                  70                  75                  80  
Leu Gly Arg Ile Gly Gln Ala Ile Ala Arg Arg Leu Lys Pro Phe Gly
                85                  90                  95      
Val Gln Arg Phe Leu Tyr Thr Gly Arg Gln Pro Arg Pro Glu Glu Ala
            100                 105                 110         
Ala Glu Phe Gln Ala Glu Phe Val Ser Thr Pro Glu Leu Ala Ala Gln
        115                 120                 125             
Ser Asp Phe Ile Val Val Ala Cys Ser Leu Thr Pro Ala Thr Glu Gly
    130                 135                 140                 
Leu Cys Asn Lys Asp Phe Phe Gln Lys Met Lys Glu Thr Ala Val Phe
145                 150                 155                 160 
Ile Asn Ile Ser Arg Gly Asp Val Val Asn Gln Asp Asp Leu Tyr Gln
                165                 170                 175     
Ala Leu Ala Ser Gly Lys Ile Ala Ala Ala Gly Leu Asp Val Thr Ser
            180                 185                 190         
Pro Glu Pro Leu Pro Thr Asn His Pro Leu Leu Thr Leu Lys Asn Cys
        195                 200                 205             
Val Ile Leu Pro His Ile Gly Ser Ala Thr His Arg Thr Arg Asn Thr
    210                 215                 220                 
Met Ser Leu Leu Ala Ala Asn Asn Leu Leu Ala Gly Leu Arg Gly Glu
225                 230                 235                 240 
Pro Met Pro Ser Glu Leu Lys Leu
                245             


<210> 1209
<211> 735
<212> PRT
<213> Homo sapiens

<400> 1209
Met Ala Lys Glu Arg Gly Leu Ile Ser Pro Ser Asp Phe Ala Gln Leu
 1               5                  10                  15      
Gln Lys Tyr Met Glu Tyr Ser Thr Lys Lys Val Ser Asp Val Leu Lys
            20                  25                  30          
Leu Phe Glu Asp Gly Glu Met Ala Lys Tyr Val Gln Gly Asp Ala Ile
        35                  40                  45              
Gly Tyr Glu Gly Phe Gln Gln Phe Leu Lys Ile Tyr Leu Glu Val Asp
    50                  55                  60                  
Asn Val Pro Arg His Leu Ser Leu Ala Leu Phe Gln Ser Phe Glu Thr
65                  70                  75                  80  
Gly His Cys Leu Asn Glu Thr Asn Val Thr Lys Asp Val Val Cys Leu
                85                  90                  95      
Asn Asp Val Ser Cys Tyr Phe Ser Leu Leu Glu Gly Gly Arg Pro Glu
            100                 105                 110         
Asp Lys Leu Glu Phe Thr Phe Lys Leu Tyr Asp Thr Asp Arg Asn Gly
        115                 120                 125             
Ile Leu Asp Ser Ser Glu Val Asp Lys Ile Ile Leu Gln Met Met Arg
    130                 135                 140                 
Val Ala Glu Tyr Leu Asp Trp Asp Val Ser Glu Leu Arg Pro Ile Leu
145                 150                 155                 160 
Gln Glu Met Met Lys Glu Ile Asp Tyr Asp Gly Ser Gly Ser Val Ser
                165                 170                 175     
Gln Ala Glu Trp Val Arg Ala Gly Ala Thr Thr Val Pro Leu Leu Val
            180                 185                 190         
Leu Leu Gly Leu Glu Met Thr Leu Lys Asp Asp Gly Gln His Met Trp
        195                 200                 205             
Arg Pro Lys Arg Phe Pro Arg Pro Val Tyr Cys Asn Leu Cys Glu Ser
    210                 215                 220                 
Ser Ile Gly Leu Gly Lys Gln Gly Leu Ser Cys Asn Leu Cys Lys Tyr
225                 230                 235                 240 
Thr Val His Asp Gln Cys Ala Met Lys Ala Leu Pro Cys Glu Val Ser
                245                 250                 255     
Thr Tyr Ala Lys Ser Arg Lys Asp Ile Gly Val Gln Ser His Val Trp
            260                 265                 270         
Val Arg Gly Gly Cys Glu Ser Gly Arg Cys Asp Arg Cys Gln Lys Lys
        275                 280                 285             
Ile Arg Ile Tyr His Ser Leu Thr Gly Leu His Cys Val Trp Cys His
    290                 295                 300                 
Leu Glu Ile His Asp Asp Cys Leu Gln Ala Val Gly His Glu Cys Asp
305                 310                 315                 320 
Cys Gly Leu Leu Arg Asp His Ile Leu Pro Pro Ser Ser Ile Tyr Pro
                325                 330                 335     
Ser Val Leu Ala Ser Gly Pro Asp Arg Lys Asn Ser Lys Thr Ser Gln
            340                 345                 350         
Lys Thr Met Asp Asp Leu Asn Leu Ser Thr Ser Glu Ala Leu Arg Ile
        355                 360                 365             
Asp Pro Val Pro Asn Thr His Pro Leu Leu Val Phe Val Asn Pro Lys
    370                 375                 380                 
Ser Gly Gly Lys Gln Gly Gln Arg Val Leu Trp Lys Phe Gln Tyr Ile
385                 390                 395                 400 
Leu Asn Pro Arg Gln Val Phe Asn Leu Leu Lys Asp Gly Pro Glu Ile
                405                 410                 415     
Gly Leu Arg Leu Phe Lys Asp Val Pro Asp Ser Arg Ile Leu Val Cys
            420                 425                 430         
Gly Gly Asp Gly Thr Val Gly Trp Ile Leu Glu Thr Ile Asp Lys Ala
        435                 440                 445             
Asn Leu Pro Val Leu Pro Pro Val Ala Val Leu Pro Leu Gly Thr Gly
    450                 455                 460                 
Asn Asp Leu Ala Arg Cys Leu Arg Trp Gly Gly Gly Tyr Glu Gly Gln
465                 470                 475                 480 
Asn Leu Ala Lys Ile Leu Lys Asp Leu Glu Met Ser Lys Val Val His
                485                 490                 495     
Met Asp Arg Trp Ser Val Glu Val Ile Pro Gln Gln Thr Glu Glu Lys
            500                 505                 510         
Ser Asp Pro Val Pro Phe Gln Ile Ile Asn Asn Tyr Phe Ser Ile Gly
        515                 520                 525             
Val Asp Ala Ser Ile Ala His Arg Phe His Ile Met Arg Glu Lys Tyr
    530                 535                 540                 
Pro Glu Lys Phe Asn Ser Arg Met Lys Asn Lys Leu Trp Tyr Phe Glu
545                 550                 555                 560 
Phe Ala Thr Ser Glu Ser Ile Phe Ser Thr Cys Lys Lys Leu Glu Glu
                565                 570                 575     
Ser Leu Thr Val Glu Ile Cys Gly Lys Pro Leu Asp Leu Ser Asn Leu
            580                 585                 590         
Ser Leu Glu Gly Ile Ala Val Leu Asn Ile Pro Ser Met His Gly Gly
        595                 600                 605             
Ser Asn Leu Trp Gly Asp Thr Arg Arg Pro His Gly Asp Ile Tyr Gly
    610                 615                 620                 
Ile Asn Gln Ala Leu Gly Ala Thr Ala Lys Val Ile Thr Asp Pro Asp
625                 630                 635                 640 
Ile Leu Lys Thr Cys Val Pro Asp Leu Ser Asp Lys Arg Leu Glu Val
                645                 650                 655     
Val Gly Leu Glu Gly Ala Ile Glu Met Gly Gln Ile Tyr Thr Lys Leu
            660                 665                 670         
Lys Asn Ala Gly Arg Arg Leu Ala Lys Cys Ser Glu Ile Thr Phe His
        675                 680                 685             
Thr Thr Lys Thr Leu Pro Met Gln Ile Asp Val Glu Pro Trp Met Gln
    690                 695                 700                 
Thr Pro Cys Thr Ile Lys Ile Thr His Lys Asn Gln Met Pro Met Leu
705                 710                 715                 720 
Met Gly Pro Pro Pro Arg Ser Thr Asn Phe Phe Gly Phe Leu Ser
                725                 730                 735 


<210> 1210
<211> 126
<212> PRT
<213> Homo sapiens

<400> 1210
Met Trp Tyr Leu Ala Lys Leu Ile Arg Gly Met Ser Ile Asp Gln Ala
 1               5                  10                  15      
Leu Ala Gln Leu Glu Phe Asn Asp Lys Lys Gly Ala Lys Ile Ile Lys
            20                  25                  30          
Glu Val Leu Leu Glu Ala Gln Asp Met Ala Val Arg Asp His Asn Val
        35                  40                  45              
Glu Phe Arg Ser Asn Leu Tyr Ile Ala Glu Ser Thr Ser Gly Arg Gly
    50                  55                  60                  
Gln Cys Leu Lys Arg Ile Arg Tyr His Gly Arg Gly Arg Phe Gly Ile
65                  70                  75                  80  
Met Glu Lys Val Tyr Cys His Tyr Phe Val Lys Leu Val Glu Gly Pro
                85                  90                  95      
Pro Pro Pro Pro Glu Pro Pro Lys Thr Ala Val Ala His Ala Lys Glu
            100                 105                 110         
Tyr Ile Gln Gln Leu Arg Ser Arg Thr Ile Val His Thr Leu
        115                 120                 125     


<210> 1211
<211> 955
<212> PRT
<213> Homo sapiens

<400> 1211
Met Val Asn Pro Thr Leu Gly Val His Glu Ala Asp Leu Leu Lys Thr
 1               5                  10                  15      
Ser Gly Thr Leu Ile Ser Phe Ile Tyr Pro Ala Gln Asn Pro Glu Leu
            20                  25                  30          
Leu Asn Lys Leu Ser Gln Arg Lys Thr Thr Val Leu Ala Met Asp Gln
        35                  40                  45              
Val Pro Arg Val Thr Ile Ala Gln Gly Tyr Asp Ala Leu Ser Ser Met
    50                  55                  60                  
Ala Asn Ile Ala Gly Tyr Lys Ala Val Val Leu Ala Ala Asn His Phe
65                  70                  75                  80  
Gly Arg Phe Phe Thr Gly Gln Ile Thr Ala Ala Gly Lys Val Pro Pro
                85                  90                  95      
Ala Lys Ile Leu Ile Val Gly Gly Gly Val Ala Gly Leu Ala Ser Ala
            100                 105                 110         
Gly Ala Ala Lys Ser Met Gly Ala Ile Val Arg Gly Phe Asp Thr Arg
        115                 120                 125             
Ala Ala Ala Leu Glu Gln Phe Lys Ser Leu Gly Ala Glu Pro Leu Glu
    130                 135                 140                 
Val Asp Leu Lys Glu Ser Gly Glu Gly Gln Gly Gly Tyr Ala Lys Glu
145                 150                 155                 160 
Met Ser Lys Glu Phe Ile Glu Ala Glu Met Lys Leu Phe Ala Gln Gln
                165                 170                 175     
Cys Lys Glu Val Asp Ile Leu Ile Ser Thr Ala Leu Ile Pro Gly Lys
            180                 185                 190         
Lys Ala Pro Val Leu Phe Asn Lys Glu Met Ile Glu Ser Met Lys Glu
        195                 200                 205             
Gly Ser Val Val Val Asp Leu Ala Ala Glu Ala Gly Gly Asn Phe Glu
    210                 215                 220                 
Thr Thr Lys Pro Gly Glu Leu Tyr Ile His Lys Gly Ile Thr His Ile
225                 230                 235                 240 
Gly Tyr Thr Asp Leu Pro Ser Arg Met Ala Thr Gln Ala Ser Thr Leu
                245                 250                 255     
Tyr Ser Asn Asn Ile Thr Lys Leu Leu Lys Ala Ile Ser Pro Asp Lys
            260                 265                 270         
Asp Asn Phe Tyr Phe Asp Val Lys Asp Asp Phe Asp Phe Gly Thr Met
        275                 280                 285             
Gly His Val Ile Arg Gly Thr Val Val Met Lys Asp Gly Lys Val Ile
    290                 295                 300                 
Phe Pro Ala Pro Thr Pro Lys Asn Ile Pro Gln Gly Ala Pro Val Lys
305                 310                 315                 320 
Gln Lys Thr Val Ala Glu Leu Glu Ala Glu Lys Ala Ala Thr Ile Thr
                325                 330                 335     
Pro Phe Arg Lys Thr Met Ser Thr Ala Ser Ala Tyr Thr Ala Gly Leu
            340                 345                 350         
Thr Gly Ile Leu Gly Leu Gly Ile Ala Ala Pro Asn Leu Ala Phe Ser
        355                 360                 365             
Gln Met Val Thr Thr Phe Gly Leu Ala Gly Ile Val Gly Tyr His Thr
    370                 375                 380                 
Val Trp Gly Val Thr Pro Ala Leu His Ser Pro Leu Met Ser Val Thr
385                 390                 395                 400 
Asn Ala Ile Ser Gly Leu Thr Ala Val Gly Gly Leu Ala Leu Met Gly
                405                 410                 415     
Gly His Leu Tyr Pro Ser Thr Thr Ser Gln Gly Leu Ala Ala Leu Ala
            420                 425                 430         
Ala Phe Ile Ser Ser Val Asn Ile Ala Gly Gly Phe Leu Val Thr Gln
        435                 440                 445             
Arg Met Leu Asp Met Phe Lys Arg Pro Thr Asp Pro Pro Glu Tyr Asn
    450                 455                 460                 
Tyr Leu Tyr Leu Leu Pro Ala Gly Thr Phe Val Gly Gly Tyr Leu Ala
465                 470                 475                 480 
Ala Leu Tyr Ser Gly Tyr Asn Ile Glu Gln Ile Met Tyr Leu Gly Ser
                485                 490                 495     
Gly Leu Cys Cys Val Gly Ala Leu Ala Gly Leu Ser Thr Gln Gly Thr
            500                 505                 510         
Ala Arg Leu Gly Asn Ala Leu Gly Met Ile Gly Val Ala Gly Gly Leu
        515                 520                 525             
Ala Ala Thr Leu Gly Val Leu Lys Pro Gly Pro Glu Leu Leu Ala Gln
    530                 535                 540                 
Met Ser Gly Ala Met Ala Leu Gly Gly Thr Ile Gly Leu Thr Ile Ala
545                 550                 555                 560 
Lys Arg Ile Gln Ile Ser Asp Leu Pro Gln Leu Val Ala Ala Phe His
                565                 570                 575     
Ser Leu Val Gly Leu Ala Ala Val Leu Thr Cys Ile Ala Glu Tyr Ile
            580                 585                 590         
Ile Glu Tyr Pro His Phe Ala Thr Asp Ala Ala Ala Asn Leu Thr Lys
        595                 600                 605             
Ile Val Ala Tyr Leu Gly Thr Tyr Ile Gly Gly Val Thr Phe Ser Gly
    610                 615                 620                 
Ser Leu Ile Ala Tyr Gly Lys Leu Gln Gly Leu Leu Lys Ser Ala Pro
625                 630                 635                 640 
Leu Leu Leu Pro Gly Arg His Leu Leu Asn Ala Gly Leu Leu Ala Ala
                645                 650                 655     
Ser Val Gly Gly Ile Ile Pro Phe Met Val Asp Pro Ser Phe Thr Thr
            660                 665                 670         
Gly Ile Thr Cys Leu Gly Ser Val Ser Ala Leu Ser Ala Val Met Gly
        675                 680                 685             
Val Thr Leu Thr Ala Ala Ile Gly Gly Ala Asp Met Pro Val Val Ile
    690                 695                 700                 
Thr Val Leu Asn Ser Tyr Ser Gly Trp Ala Leu Cys Ala Glu Gly Phe
705                 710                 715                 720 
Leu Leu Asn Asn Asn Leu Leu Thr Ile Val Gly Ala Leu Ile Gly Ser
                725                 730                 735     
Ser Gly Ala Ile Leu Ser Tyr Ile Met Cys Val Ala Met Asn Arg Ser
            740                 745                 750         
Leu Ala Asn Val Ile Leu Gly Gly Tyr Gly Thr Thr Ser Thr Ala Gly
        755                 760                 765             
Gly Lys Pro Met Glu Ile Ser Gly Thr His Thr Glu Ile Asn Leu Asp
    770                 775                 780                 
Asn Ala Ile Asp Met Ile Arg Glu Ala Asn Ser Ile Ile Ile Thr Pro
785                 790                 795                 800 
Gly Tyr Gly Leu Cys Ala Ala Lys Ala Gln Tyr Pro Ile Ala Asp Leu
                805                 810                 815     
Val Lys Met Leu Thr Glu Gln Gly Lys Lys Val Arg Phe Gly Ile His
            820                 825                 830         
Pro Val Ala Gly Arg Met Pro Gly Gln Leu Asn Val Leu Leu Ala Glu
        835                 840                 845             
Ala Gly Val Pro Tyr Asp Ile Val Leu Glu Met Asp Glu Ile Asn His
    850                 855                 860                 
Asp Phe Pro Asp Thr Asp Leu Val Leu Val Ile Gly Ala Asn Asp Thr
865                 870                 875                 880 
Val Asn Ser Ala Ala Gln Glu Asp Pro Asn Ser Ile Ile Ala Gly Met
                885                 890                 895     
Pro Val Leu Glu Val Trp Lys Ser Lys Gln Val Ile Val Met Lys Arg
            900                 905                 910         
Ser Leu Gly Val Gly Tyr Ala Ala Val Asp Asn Pro Ile Phe Tyr Lys
        915                 920                 925             
Pro Asn Thr Ala Met Leu Leu Gly Asp Ala Lys Lys Thr Cys Asp Ala
    930                 935                 940                 
Leu Gln Ala Lys Val Arg Glu Ser Tyr Gln Lys
945                 950                 955 


<210> 1212
<211> 82
<212> PRT
<213> Homo sapiens

<400> 1212
Met Gly Arg Glu Phe Gly Asn Leu Thr Arg Met Arg His Val Ile Ser
 1               5                  10                  15      
Tyr Ser Leu Ser Pro Phe Glu Gln Arg Ala Tyr Pro His Val Phe Thr
            20                  25                  30          
Lys Gly Ile Pro Asn Val Leu Arg Arg Ile Arg Glu Ser Phe Phe Arg
        35                  40                  45              
Val Val Pro Gln Phe Val Val Phe Tyr Leu Ile Tyr Thr Trp Gly Thr
    50                  55                  60                  
Glu Glu Phe Glu Arg Ser Lys Arg Lys Asn Pro Ala Ala Tyr Glu Asn
65                  70                  75                  80  
Asp Lys
        


<210> 1213
<211> 82
<212> PRT
<213> Homo sapiens

<400> 1213
Met Gly Arg Glu Phe Gly Asn Leu Thr Arg Met Arg His Val Ile Ser
 1               5                  10                  15      
Tyr Ser Leu Ser Pro Phe Glu Gln Arg Ala Tyr Pro His Val Phe Thr
            20                  25                  30          
Lys Gly Ile Pro Asn Val Leu Arg Arg Ile Arg Glu Ser Phe Phe Arg
        35                  40                  45              
Val Val Pro Gln Phe Val Val Phe Tyr Leu Ile Tyr Thr Trp Gly Thr
    50                  55                  60                  
Glu Glu Phe Glu Arg Ser Lys Arg Lys Asn Pro Ala Ala Tyr Glu Asn
65                  70                  75                  80  
Asp Lys
        


<210> 1214
<211> 639
<212> PRT
<213> Homo sapiens

<400> 1214
Met Glu Asp Ser Gln Asp Leu Asn Glu Gln Ser Val Lys Lys Thr Cys
 1               5                  10                  15      
Thr Glu Ser Asp Val Ser Gln Ser Gln Asn Ser Arg Ser Met Glu Met
            20                  25                  30          
Gln Asp Leu Ala Ser Pro His Thr Leu Val Gly Gly Gly Asp Thr Pro
        35                  40                  45              
Gly Ser Ser Lys Leu Glu Lys Ser Asn Leu Ser Ser Thr Ser Val Thr
    50                  55                  60                  
Thr Asn Gly Thr Gly Gly Glu Asn Met Thr Val Leu Asn Thr Ala Asp
65                  70                  75                  80  
Trp Leu Leu Ser Cys Asn Thr Pro Ser Ser Ala Thr Met Ser Leu Leu
                85                  90                  95      
Ala Val Lys Thr Glu Pro Leu Asn Ser Ser Glu Thr Thr Ala Thr Thr
            100                 105                 110         
Gly Asp Gly Ala Leu Asp Thr Phe Thr Gly Ser Val Ile Thr Ser Ser
        115                 120                 125             
Gly Tyr Ser Pro Arg Ser Ala His Gln Tyr Ser Pro Gln Leu Tyr Pro
    130                 135                 140                 
Ser Lys Pro Tyr Pro His Ile Leu Ser Thr Pro Ala Ala Gln Thr Met
145                 150                 155                 160 
Ser Ala Tyr Ala Gly Gln Thr Gln Tyr Ser Gly Met Gln Gln Pro Ala
                165                 170                 175     
Val Tyr Thr Ala Tyr Ser Gln Thr Gly Gln Pro Tyr Ser Leu Pro Thr
            180                 185                 190         
Tyr Asp Leu Gly Val Met Leu Pro Ala Ile Lys Thr Glu Ser Gly Leu
        195                 200                 205             
Ser Gln Thr Gln Ser Pro Leu Gln Ser Gly Cys Leu Ser Tyr Ser Pro
    210                 215                 220                 
Gly Phe Ser Thr Pro Gln Pro Gly Gln Thr Pro Tyr Ser Tyr Gln Met
225                 230                 235                 240 
Pro Gly Ser Ser Phe Ala Pro Ser Ser Thr Ile Tyr Ala Asn Asn Ser
                245                 250                 255     
Val Ser Asn Ser Thr Asn Phe Ser Gly Ser Gln Gln Asp Tyr Pro Ser
            260                 265                 270         
Tyr Thr Ala Phe Gly Gln Asn Gln Tyr Ala Gln Tyr Tyr Ser Ala Ser
        275                 280                 285             
Thr Tyr Gly Ala Tyr Met Thr Ser Asn Asn Thr Ala Asp Gly Thr Pro
    290                 295                 300                 
Ser Ser Thr Ser Thr Tyr Gln Leu Gln Glu Ser Leu Pro Gly Leu Thr
305                 310                 315                 320 
Asn Gln Pro Gly Glu Phe Asp Thr Met Gln Ser Pro Ser Thr Pro Ile
                325                 330                 335     
Lys Asp Leu Asp Glu Arg Thr Cys Arg Ser Ser Gly Ser Lys Ser Arg
            340                 345                 350         
Gly Arg Gly Arg Lys Asn Asn Pro Ser Pro Pro Pro Asp Ser Asp Leu
        355                 360                 365             
Glu Arg Val Phe Val Trp Asp Leu Asp Glu Thr Ile Ile Val Phe His
    370                 375                 380                 
Ser Leu Leu Thr Gly Ser Tyr Ala Gln Lys Tyr Gly Lys Asp Pro Pro
385                 390                 395                 400 
Met Ala Val Thr Leu Gly Leu Arg Met Glu Glu Met Ile Phe Asn Leu
                405                 410                 415     
Ala Asp Thr His Leu Phe Phe Asn Asp Leu Glu Glu Cys Asp Gln Val
            420                 425                 430         
His Ile Asp Asp Val Ser Ser Asp Asp Asn Gly Gln Asp Leu Ser Thr
        435                 440                 445             
Tyr Ser Phe Ala Thr Asp Gly Phe His Ala Ala Ala Ser Ser Ala Asn
    450                 455                 460                 
Leu Cys Leu Pro Thr Gly Val Arg Gly Gly Val Asp Trp Met Arg Lys
465                 470                 475                 480 
Leu Ala Phe Arg Tyr Arg Arg Val Lys Glu Leu Tyr Asn Thr Tyr Lys
                485                 490                 495     
Asn Asn Val Gly Gly Leu Leu Gly Pro Ala Lys Arg Asp Ala Trp Leu
            500                 505                 510         
Gln Leu Arg Ala Glu Ile Glu Gly Leu Thr Asp Ser Trp Leu Thr Asn
        515                 520                 525             
Ala Leu Lys Ser Leu Ser Ile Ile Ser Thr Arg Ser Asn Cys Ile Asn
    530                 535                 540                 
Val Leu Val Thr Thr Thr Gln Leu Ile Pro Ala Leu Ala Lys Val Leu
545                 550                 555                 560 
Leu Tyr Ser Leu Gly Gly Ala Phe Pro Ile Glu Asn Ile Tyr Ser Ala
                565                 570                 575     
Thr Lys Ile Gly Lys Glu Ser Cys Phe Glu Arg Ile Met Gln Arg Phe
            580                 585                 590         
Gly Arg Lys Val Val Tyr Val Val Ile Gly Asp Gly Val Glu Glu Glu
        595                 600                 605             
Gln Ala Ala Lys Lys His Asn Met Pro Phe Trp Arg Ile Ser Ser His
    610                 615                 620                 
Ser Asp Leu Leu Ala Leu His Gln Ala Leu Glu Leu Glu Tyr Leu
625                 630                 635                 


<210> 1215
<211> 1327
<212> PRT
<213> Homo sapiens

<400> 1215
Met Glu Ile Glu Glu Glu Ser Ala Glu Lys Ile Gln Phe Leu Lys Ser
 1               5                  10                  15      
Ser Gly Thr Ser Leu Leu Ser Thr Asp Ser Leu Glu Thr Asn Glu Leu
            20                  25                  30          
Val Val Ser Glu Leu Asn His Ser Ser Leu Gly Val Gly Leu Asp Thr
        35                  40                  45              
Leu Glu Glu Gln Glu Glu Lys Glu Gln Phe Phe Ala Arg Leu Glu Lys
    50                  55                  60                  
Gly Leu Thr Ser Ser Ile Asp Tyr Ser Arg Leu Asn Lys Glu Leu Asp
65                  70                  75                  80  
Ser Asn Asp Ser Thr His Phe Lys Ala Leu His Ser Asn Gln Ala Asn
                85                  90                  95      
Ala Glu Leu Thr Asp Asp Glu His Glu Asn Glu Ser Lys His Glu Glu
            100                 105                 110         
Leu Ala Glu Asn Tyr Ser Asp Asp Phe Glu Asp Glu Tyr Val Gly Ala
        115                 120                 125             
Pro Leu Thr Thr Lys Asp Glu Glu Met Pro Ser Lys Glu Asn Ser Lys
    130                 135                 140                 
Ser Glu Lys Ile Ser Val Pro Lys Gln Glu Glu Glu Lys Thr Gly Met
145                 150                 155                 160 
Leu Ala Asn Val Val Leu Leu Asp Ser Leu Asp Ser Val Ala Glu Val
                165                 170                 175     
Asn Leu Asp Glu Gln Asp Lys Ile Thr Pro Lys Pro Arg Cys Leu Pro
            180                 185                 190         
Glu Met Thr Glu Asn Glu Met Thr Gly Thr Gly Val Ser Tyr Gly Gln
        195                 200                 205             
Ser Ser Ser Asp Val Glu Ala Leu His Gln Ala Tyr Cys His Ile Ala
    210                 215                 220                 
His Ser Leu Gly Asp Glu Asp Lys Gln Lys Ile Glu Ser Asn Thr Val
225                 230                 235                 240 
Glu Asp Ile Lys Ser Ser Val Lys Gly His Pro Gln Glu Asn Glu Glu
                245                 250                 255     
Asn Ser Lys Asn Ile Ser Thr Met Glu Ser Asp Leu Pro Thr Val Glu
            260                 265                 270         
Glu Leu Met Lys Pro Ile Arg Ile Asp Ser Phe Gly Ile Ser Gly Phe
        275                 280                 285             
Asp Leu Gln Pro Val Ser Ser Glu Lys Val Ala Glu Arg Lys Glu Thr
    290                 295                 300                 
Glu Phe Phe Ser Ser Leu Pro Leu Lys Met Asn Pro Asn Ile Leu Ser
305                 310                 315                 320 
Gln Asp Ser Gln His Val Asn Leu Phe Phe Asp Lys Asn Asp Glu Asn
                325                 330                 335     
Val Ile Leu Gln Lys Thr Thr Asn Glu Ser Met Glu Asn Ser Cys Pro
            340                 345                 350         
Gln Val Thr Glu Val Thr Ala Thr Glu Glu His Val Asp Lys Met Tyr
        355                 360                 365             
Leu Asn Ile Leu Arg Lys Lys Ile Thr Val Asn Ser Ser Ser Leu Ser
    370                 375                 380                 
Gln Asp Asp Lys Ile Asn Lys Thr Tyr Arg Ser Gln Leu Ser Ser Glu
385                 390                 395                 400 
Glu Glu Gly Ala Val Met Gly Lys Gln Val Pro Tyr Lys Lys Ala Arg
                405                 410                 415     
Ser Ala Pro Pro Leu Leu Lys Arg Lys Pro Gln Ser Gly Leu Tyr Ala
            420                 425                 430         
Ser Val Arg Ser Ser Gly Tyr Gly Lys Pro Ser Ser Pro Leu Lys Met
        435                 440                 445             
Phe Ser Thr Leu Glu Lys Lys Thr Ser Glu Asp Ile Ile Lys Ser Lys
    450                 455                 460                 
Asn Leu Arg Ser Ile Ser Thr Ser Asn Gln Pro Arg Lys Lys Glu Ile
465                 470                 475                 480 
Leu Ser Gly Thr Lys Leu Ile Lys Pro Ala Ala Leu Asp Lys Pro Ala
                485                 490                 495     
His Lys Thr Glu Ser Cys Leu Ser Thr Arg Lys Lys Ser Glu Asn Pro
            500                 505                 510         
Thr Glu Thr Asp Ser Cys Ile Gln Phe Gln Thr Asp Ser Leu Gly Tyr
        515                 520                 525             
Cys Gly Glu Asn Lys Glu Lys Lys Leu Leu Met Phe Lys Arg Val Gln
    530                 535                 540                 
Glu Ala Glu Asp Lys Trp Arg Gly Ala Gln Ala Leu Ile Glu Gln Ile
545                 550                 555                 560 
Lys Ala Thr Phe Ser Glu Lys Glu Lys Glu Leu Glu Asn Lys Leu Glu
                565                 570                 575     
Glu Leu Lys Lys Gln Gln Glu Lys Glu Leu Phe Lys Leu Asn Gln Asp
            580                 585                 590         
Asn Tyr Ile Leu Gln Ala Lys Leu Ser Ser Phe Glu Glu Thr Asn Lys
        595                 600                 605             
Lys Gln Arg Trp Leu His Phe Gly Glu Ala Ala Asp Pro Val Thr Gly
    610                 615                 620                 
Glu Lys Leu Lys Gln Ile Gln Lys Glu Ile Gln Glu Gln Glu Thr Leu
625                 630                 635                 640 
Leu Gln Gly Tyr Gln Gln Glu Asn Glu Arg Leu Tyr Asn Gln Val Lys
                645                 650                 655     
Asp Leu Gln Glu Gln Asn Lys Lys Asn Glu Glu Arg Met Phe Lys Glu
            660                 665                 670         
Asn Gln Ser Leu Phe Ser Glu Val Ala Ser Leu Lys Glu Gln Met His
        675                 680                 685             
Lys Ser Arg Phe Leu Ser Gln Val Val Glu Asp Ser Glu Pro Thr Arg
    690                 695                 700                 
Asn Gln Asn Phe Thr Asp Leu Leu Ala Glu Leu Arg Met Ala Gln Lys
705                 710                 715                 720 
Glu Lys Asp Ser Leu Leu Glu Asp Ile Lys Arg Leu Lys Gln Asp Lys
                725                 730                 735     
Gln Ala Leu Glu Val Asp Phe Glu Lys Met Lys Lys Glu Arg Asp Gln
            740                 745                 750         
Ala Lys Asp Gln Ile Ala Tyr Val Thr Gly Glu Lys Leu Tyr Glu Ile
        755                 760                 765             
Lys Ile Leu Glu Glu Thr His Lys Gln Glu Ile Ser Arg Leu Gln Lys
    770                 775                 780                 
Arg Leu Gln Trp Tyr Ala Glu Asn Gln Glu Leu Leu Asp Lys Asp Ala
785                 790                 795                 800 
Leu Arg Leu Arg Glu Ala Asn Glu Glu Ile Glu Lys Leu Lys Leu Glu
                805                 810                 815     
Ile Glu Lys Leu Lys Ala Glu Ser Gly Asn Pro Ser Ile Arg Gln Lys
            820                 825                 830         
Ile Arg Leu Lys Asp Lys Ala Ala Asp Ala Lys Lys Ile Gln Asp Leu
        835                 840                 845             
Glu Arg Gln Val Lys Glu Met Glu Gly Ile Leu Lys Arg Arg Tyr Pro
    850                 855                 860                 
Asn Ser Leu Pro Ala Leu Ile Leu Ala Ala Ser Ala Ala Gly Asp Thr
865                 870                 875                 880 
Val Asp Lys Asn Thr Val Glu Phe Met Glu Lys Arg Ile Lys Lys Leu
                885                 890                 895     
Glu Ala Asp Leu Glu Gly Lys Asp Glu Asp Ala Lys Lys Ser Leu Arg
            900                 905                 910         
Thr Met Glu Gln Gln Phe Gln Lys Met Lys Ile Gln Tyr Glu Gln Arg
        915                 920                 925             
Leu Glu Gln Gln Glu Gln Leu Leu Ala Cys Lys Leu Asn Gln His Asp
    930                 935                 940                 
Ser Pro Arg Ile Lys Ala Leu Glu Lys Glu Leu Asp Asp Ile Lys Glu
945                 950                 955                 960 
Ala His Gln Ile Thr Val Arg Asn Leu Glu Ala Glu Ile Asp Val Leu
                965                 970                 975     
Lys His Gln Asn Ala Glu Leu Asp Val Lys Lys Asn Asp Lys Asp Asp
            980                 985                 990         
Glu Asp Phe Gln Ser Ile Glu Phe Gln Val Glu Gln Ala His Ala Lys
        995                 1000                1005            
Ala Lys Leu Val Arg Leu Asn Glu Glu Leu Ala Ala Lys Lys Arg Glu
    1010                1015                1020                
Ile Gln Asp Leu Ser Lys Thr Val Glu Arg Leu Gln Lys Asp Arg Arg
1025                1030                1035                1040
Met Met Leu Ser Asn Gln Asn Ser Lys Gly Arg Glu Glu Met Ser Ala
                1045                1050                1055    
Lys Arg Ala Lys Lys Asp Val Leu His Ser Ser Lys Gly Asn Ala Asn
            1060                1065                1070        
Ser Phe Pro Gly Thr Leu Asp Ser Lys Leu Tyr Gln Pro His Thr Phe
        1075                1080                1085            
Thr Asp Ser His Val Ser Glu Val Leu Gln Glu Asn Tyr Arg Leu Lys
    1090                1095                1100                
Asn Glu Leu Glu Gly Leu Ile Ser Glu Lys Asn Glu Leu Lys Met Lys
1105                1110                1115                1120
Ser Glu Ala Val Met Asn Gln Phe Glu Asn Ser Met Arg Arg Val Lys
                1125                1130                1135    
Glu Asp Thr Ala Ala His Ile Ala Ser Leu Lys Ala Ser His Gln Arg
            1140                1145                1150        
Glu Ile Glu Lys Leu Leu Cys Gln Asn Ala Val Glu Asn Ser Ser Ser
        1155                1160                1165            
Lys Val Ala Glu Leu Asn Arg Lys Ile Ala Thr Gln Glu Val Leu Ile
    1170                1175                1180                
Arg His Phe Gln Ser Gln Val Asn Glu Leu Gln Ser Lys Gln Glu Ser
1185                1190                1195                1200
Leu Val Val Ser Glu Val Arg Glu Glu Ile Leu Gln Lys Glu Ile Thr
                1205                1210                1215    
Lys Leu Leu Glu Glu Leu Arg Glu Ala Lys Glu Asn His Thr Pro Glu
            1220                1225                1230        
Met Lys His Phe Val Gly Leu Glu Lys Lys Ile Lys Gln Met Glu Met
        1235                1240                1245            
Arg His Ala Gln Arg Glu Gln Glu Leu Gln Gln Ile Ile Gln Gln Thr
    1250                1255                1260                
His Gln Val Val Glu Thr Glu Gln Asn Lys Glu Val Glu Lys Trp Lys
1265                1270                1275                1280
Arg Leu Ala Gln Leu Lys Asn Arg Glu Leu Glu Lys Phe Arg Thr Glu
                1285                1290                1295    
Leu Asp Ser Ile Leu Asp Val Leu Arg Glu Leu His Arg Gln Gly Val
            1300                1305                1310        
Val Val Pro Val Ala Phe Ala Asp Glu Met Asn Ala Pro Glu Tyr
        1315                1320                1325        


<210> 1216
<211> 1223
<212> PRT
<213> Homo sapiens

<400> 1216
Met Arg Ser Arg Ser Asn Ser Gly Val Arg Leu Asp Gly Tyr Ala Arg
 1               5                  10                  15      
Leu Val Gln Gln Thr Ile Leu Cys His Gln Asn Pro Val Thr Gly Leu
            20                  25                  30          
Leu Pro Ala Ser Tyr Asp Gln Lys Asp Ala Trp Val Arg Asp Asn Val
        35                  40                  45              
Tyr Ser Ile Leu Ala Val Trp Gly Leu Gly Leu Ala Tyr Arg Lys Asn
    50                  55                  60                  
Ala Asp Arg Asp Glu Asp Lys Ala Lys Ala Tyr Glu Leu Glu Gln Ser
65                  70                  75                  80  
Val Val Lys Leu Met Arg Gly Leu Leu His Cys Met Ile Arg Gln Val
                85                  90                  95      
Asp Lys Val Glu Ser Phe Lys Tyr Ser Gln Ser Thr Lys Asp Ser Leu
            100                 105                 110         
His Ala Lys Tyr Asn Thr Lys Thr Cys Ala Thr Val Val Gly Asp Asp
        115                 120                 125             
Gln Trp Gly His Leu Gln Leu Asp Ala Thr Ser Val Tyr Leu Leu Phe
    130                 135                 140                 
Leu Ala Gln Met Thr Ala Ser Gly Leu His Ile Ile His Ser Leu Asp
145                 150                 155                 160 
Glu Val Asn Phe Ile Gln Asn Leu Val Phe Tyr Ile Glu Ala Ala Tyr
                165                 170                 175     
Lys Thr Ala Asp Phe Gly Ile Trp Glu Arg Gly Asp Lys Thr Asn Gln
            180                 185                 190         
Gly Ile Ser Glu Leu Asn Ala Ser Ser Val Gly Met Ala Lys Ala Ala
        195                 200                 205             
Leu Glu Ala Leu Asp Glu Leu Asp Leu Phe Gly Val Lys Gly Gly Pro
    210                 215                 220                 
Gln Ser Val Ile His Val Leu Ala Asp Glu Val Gln His Cys Gln Ser
225                 230                 235                 240 
Ile Leu Asn Ser Leu Leu Pro Arg Ala Ser Thr Ser Lys Glu Val Asp
                245                 250                 255     
Ala Ser Leu Leu Ser Val Val Ser Phe Pro Ala Phe Ala Val Glu Asp
            260                 265                 270         
Ser Gln Leu Val Glu Leu Thr Lys Gln Glu Ile Ile Thr Lys Leu Gln
        275                 280                 285             
Gly Arg Tyr Gly Cys Cys Arg Phe Leu Arg Asp Gly Tyr Lys Thr Pro
    290                 295                 300                 
Lys Glu Asp Pro Asn Arg Leu Tyr Tyr Glu Pro Ala Glu Leu Lys Leu
305                 310                 315                 320 
Phe Glu Asn Ile Glu Cys Glu Trp Pro Leu Phe Trp Thr Tyr Phe Ile
                325                 330                 335     
Leu Asp Gly Val Phe Ser Gly Asn Ala Glu Gln Val Gln Glu Tyr Lys
            340                 345                 350         
Glu Ala Leu Glu Ala Val Leu Ile Lys Gly Lys Asn Gly Val Pro Leu
        355                 360                 365             
Leu Pro Glu Leu Tyr Ser Val Pro Pro Asp Arg Val Asp Glu Glu Tyr
    370                 375                 380                 
Gln Asn Pro His Thr Val Asp Arg Val Pro Met Gly Lys Leu Pro His
385                 390                 395                 400 
Met Trp Gly Gln Ser Leu Tyr Ile Leu Gly Ser Leu Met Ala Glu Gly
                405                 410                 415     
Phe Leu Ala Pro Gly Glu Ile Asp Pro Leu Asn Arg Arg Phe Ser Thr
            420                 425                 430         
Val Pro Lys Pro Asp Val Val Val Gln Val Ser Ile Leu Ala Glu Thr
        435                 440                 445             
Glu Glu Ile Lys Thr Ile Leu Lys Asp Lys Gly Ile Tyr Val Glu Thr
    450                 455                 460                 
Ile Ala Glu Val Tyr Pro Ile Arg Val Gln Pro Ala Arg Ile Leu Ser
465                 470                 475                 480 
His Ile Tyr Ser Ser Leu Gly Cys Asn Asn Arg Met Lys Leu Ser Gly
                485                 490                 495     
Arg Pro Tyr Arg His Met Gly Val Leu Gly Thr Ser Lys Leu Tyr Asp
            500                 505                 510         
Ile Arg Lys Thr Ile Phe Thr Phe Thr Pro Gln Phe Ile Asp Gln Gln
        515                 520                 525             
Gln Phe Tyr Leu Ala Leu Asp Asn Lys Met Ile Val Glu Met Leu Arg
    530                 535                 540                 
Thr Asp Leu Ser Tyr Leu Cys Ser Arg Trp Arg Met Thr Gly Gln Pro
545                 550                 555                 560 
Thr Ile Thr Phe Pro Ile Ser His Ser Met Leu Asp Glu Asp Gly Thr
                565                 570                 575     
Ser Leu Asn Ser Ser Ile Leu Ala Ala Leu Arg Lys Met Gln Asp Gly
            580                 585                 590         
Tyr Phe Gly Gly Ala Arg Val Gln Thr Gly Lys Leu Ser Glu Phe Leu
        595                 600                 605             
Thr Thr Ser Cys Cys Thr His Leu Ser Phe Met Asp Pro Gly Pro Glu
    610                 615                 620                 
Gly Lys Leu Tyr Ser Glu Asp Tyr Asp Asp Asn Tyr Asp Tyr Leu Glu
625                 630                 635                 640 
Ser Gly Asn Trp Met Asn Asp Tyr Asp Ser Thr Ser His Ala Arg Cys
                645                 650                 655     
Gly Asp Glu Val Ala Arg Tyr Leu Asp His Leu Leu Ala His Thr Ala
            660                 665                 670         
Pro His Pro Lys Leu Ala Pro Thr Ser Gln Lys Gly Gly Leu Asp Arg
        675                 680                 685             
Phe Gln Ala Ala Val Gln Thr Thr Cys Asp Leu Met Ser Leu Val Thr
    690                 695                 700                 
Lys Ala Lys Glu Leu His Val Gln Asn Val His Met Tyr Leu Pro Thr
705                 710                 715                 720 
Lys Leu Phe Gln Ala Ser Arg Pro Ser Phe Asn Leu Leu Asp Ser Pro
                725                 730                 735     
His Pro Arg Gln Glu Asn Gln Val Pro Ser Val Arg Val Glu Ile His
            740                 745                 750         
Leu Pro Arg Asp Gln Ser Gly Glu Val Asp Phe Lys Ala Leu Val Leu
        755                 760                 765             
Gln Leu Lys Glu Thr Ser Ser Leu Gln Glu Gln Ala Asp Ile Leu Tyr
    770                 775                 780                 
Met Leu Tyr Thr Met Lys Gly Pro Asp Trp Asn Thr Glu Leu Tyr Asn
785                 790                 795                 800 
Glu Arg Ser Ala Thr Val Arg Glu Leu Leu Thr Glu Leu Tyr Gly Lys
                805                 810                 815     
Val Gly Glu Ile Arg His Trp Gly Leu Ile Arg Tyr Ile Ser Gly Ile
            820                 825                 830         
Leu Arg Lys Lys Val Glu Ala Leu Asp Glu Ala Cys Thr Asp Leu Leu
        835                 840                 845             
Ser His Gln Lys His Leu Thr Val Gly Leu Pro Pro Glu Pro Arg Glu
    850                 855                 860                 
Lys Thr Ile Ser Ala Pro Leu Pro Tyr Glu Ala Leu Thr Gln Leu Ile
865                 870                 875                 880 
Asp Glu Ala Ser Glu Gly Asp Met Ser Ile Ser Ile Leu Thr Gln Glu
                885                 890                 895     
Ile Met Val Tyr Leu Ala Met Tyr Met Arg Thr Gln Pro Gly Leu Phe
            900                 905                 910         
Ala Glu Met Phe Arg Leu Arg Ile Gly Leu Ile Ile Gln Val Met Ala
        915                 920                 925             
Thr Glu Leu Ala His Ser Leu Arg Cys Ser Ala Glu Glu Ala Thr Glu
    930                 935                 940                 
Gly Leu Met Asn Leu Ser Pro Ser Ala Met Lys Asn Leu Leu His His
945                 950                 955                 960 
Ile Leu Ser Gly Lys Glu Phe Gly Val Glu Arg Ser Val Arg Pro Thr
                965                 970                 975     
Asp Ser Asn Val Ser Pro Ala Ile Ser Ile His Glu Ile Gly Ala Val
            980                 985                 990         
Gly Ala Thr Lys Thr Glu Arg Thr Gly Ile Met Gln Leu Lys Ser Glu
        995                 1000                1005            
Ile Lys Gln Val Glu Phe Arg Arg Leu Ser Ile Ser Ala Glu Ser Gln
    1010                1015                1020                
Ser Pro Gly Thr Ser Met Thr Pro Ser Ser Gly Ser Phe Pro Ser Ala
1025                1030                1035                1040
Tyr Asp Gln Gln Ser Ser Lys Asp Ser Arg Gln Gly Gln Trp Gln Arg
                1045                1050                1055    
Arg Arg Arg Leu Asp Gly Ala Leu Asn Arg Val Pro Val Gly Phe Tyr
            1060                1065                1070        
Gln Lys Val Trp Lys Val Leu Gln Lys Cys His Gly Leu Ser Val Glu
        1075                1080                1085            
Gly Phe Val Leu Pro Ser Ser Thr Thr Arg Glu Met Thr Pro Gly Glu
    1090                1095                1100                
Ile Lys Phe Ser Val His Val Glu Ser Val Leu Asn Arg Val Pro Gln
1105                1110                1115                1120
Pro Glu Tyr Arg Gln Leu Leu Val Glu Ala Ile Leu Val Leu Thr Met
                1125                1130                1135    
Leu Ala Asp Ile Glu Ile His Ser Ile Gly Ser Ile Ile Ala Val Glu
            1140                1145                1150        
Lys Ile Val His Ile Ala Asn Asp Leu Phe Leu Gln Glu Gln Lys Thr
        1155                1160                1165            
Leu Gly Ala Asp Asp Thr Met Leu Ala Lys Asp Pro Ala Ser Gly Ile
    1170                1175                1180                
Cys Thr Leu Leu Tyr Asp Ser Ala Pro Ser Gly Arg Phe Gly Thr Met
1185                1190                1195                1200
Thr Tyr Leu Ser Lys Ala Ala Ala Thr Tyr Val Gln Glu Phe Leu Pro
                1205                1210                1215    
His Ser Ile Cys Ala Met Gln
            1220            


<210> 1217
<211> 489
<212> PRT
<213> Homo sapiens

<400> 1217
Met Ala Ala Ala Ala Ala Arg Val Val Leu Ser Ser Ala Ala Arg Arg
 1               5                  10                  15      
Arg Leu Trp Gly Phe Ser Glu Ser Leu Leu Ile Arg Gly Ala Ala Gly
            20                  25                  30          
Arg Ser Leu Tyr Phe Gly Glu Asn Arg Leu Arg Ser Thr Gln Ala Ala
        35                  40                  45              
Thr Gln Val Val Leu Asn Val Pro Glu Thr Arg Val Thr Cys Leu Glu
    50                  55                  60                  
Ser Gly Leu Arg Val Ala Ser Glu Asp Ser Gly Leu Ser Thr Cys Thr
65                  70                  75                  80  
Val Gly Leu Trp Ile Asp Ala Gly Ser Arg Tyr Glu Asn Glu Lys Asn
                85                  90                  95      
Asn Gly Thr Ala His Phe Leu Glu His Met Ala Phe Lys Gly Thr Lys
            100                 105                 110         
Lys Arg Ser Gln Leu Asp Leu Glu Leu Glu Ile Glu Asn Met Gly Ala
        115                 120                 125             
His Leu Asn Ala Tyr Thr Ser Arg Glu Gln Thr Val Tyr Tyr Ala Lys
    130                 135                 140                 
Ala Phe Ser Lys Asp Leu Pro Arg Ala Val Glu Ile Leu Ala Asp Ile
145                 150                 155                 160 
Ile Gln Asn Ser Thr Leu Gly Glu Ala Glu Ile Glu Arg Glu Arg Gly
                165                 170                 175     
Val Ile Leu Arg Glu Met Gln Glu Val Glu Thr Asn Leu Gln Glu Val
            180                 185                 190         
Val Phe Asp Tyr Leu His Ala Thr Ala Tyr Gln Asn Thr Ala Leu Gly
        195                 200                 205             
Arg Thr Ile Leu Gly Pro Thr Glu Asn Ile Lys Ser Ile Ser Arg Lys
    210                 215                 220                 
Asp Leu Val Asp Tyr Ile Thr Thr His Tyr Lys Gly Pro Arg Ile Val
225                 230                 235                 240 
Leu Ala Ala Ala Gly Gly Val Ser His Asp Glu Leu Leu Asp Leu Ala
                245                 250                 255     
Lys Phe His Phe Gly Asp Ser Leu Cys Thr His Lys Gly Glu Ile Pro
            260                 265                 270         
Ala Leu Pro Pro Cys Lys Phe Thr Gly Ser Glu Ile Arg Val Arg Asp
        275                 280                 285             
Asp Lys Met Pro Leu Ala His Leu Ala Ile Ala Val Glu Ala Val Gly
    290                 295                 300                 
Trp Ala His Pro Asp Thr Ile Cys Leu Met Val Ala Asn Thr Leu Ile
305                 310                 315                 320 
Gly Asn Trp Asp Arg Ser Phe Gly Gly Gly Met Asn Leu Ser Ser Lys
                325                 330                 335     
Leu Ala Gln Leu Thr Cys His Gly Asn Leu Cys His Ser Phe Gln Ser
            340                 345                 350         
Phe Asn Thr Ser Tyr Thr Asp Thr Gly Leu Trp Gly Leu Tyr Met Val
        355                 360                 365             
Cys Glu Ser Ser Thr Val Ala Asp Met Leu His Val Val Gln Lys Glu
    370                 375                 380                 
Trp Met Arg Leu Cys Thr Ser Val Thr Glu Ser Glu Val Ala Arg Ala
385                 390                 395                 400 
Arg Asn Leu Leu Lys Thr Asn Met Leu Leu Gln Leu Asp Gly Ser Thr
                405                 410                 415     
Pro Ile Cys Glu Asp Ile Gly Arg Gln Met Leu Cys Tyr Asn Arg Arg
            420                 425                 430         
Ile Pro Ile Pro Glu Leu Glu Ala Arg Ile Asp Ala Val Asn Ala Glu
        435                 440                 445             
Thr Ile Arg Glu Val Cys Thr Lys Tyr Ile Tyr Asn Arg Ser Pro Ala
    450                 455                 460                 
Ile Ala Ala Val Gly Pro Ile Lys Gln Leu Pro Asp Phe Lys Gln Ile
465                 470                 475                 480 
Arg Ser Asn Met Cys Trp Leu Arg Asp
                485                 


<210> 1218
<211> 484
<212> PRT
<213> Homo sapiens

<400> 1218
Met Phe Glu Met Leu Thr Gly Ser Leu Pro Phe Gln Gly Lys Asp Arg
 1               5                  10                  15      
Lys Glu Thr Met Thr Leu Ile Leu Lys Ala Lys Leu Gly Met Pro Gln
            20                  25                  30          
Phe Leu Ser Thr Glu Ala Gln Ser Leu Leu Arg Ala Leu Phe Lys Arg
        35                  40                  45              
Asn Pro Ala Asn Arg Leu Gly Ser Gly Pro Asp Gly Ala Glu Glu Ile
    50                  55                  60                  
Lys Arg His Val Phe Tyr Ser Thr Ile Asp Trp Asn Lys Leu Tyr Arg
65                  70                  75                  80  
Arg Glu Ile Lys Pro Pro Phe Lys Pro Ala Val Ala Gln Pro Asp Asp
                85                  90                  95      
Thr Phe Tyr Phe Asp Thr Glu Phe Thr Ser Arg Thr Pro Lys Asp Ser
            100                 105                 110         
Pro Gly Ile Pro Pro Ser Ala Gly Ala His Gln Leu Phe Arg Gly Phe
        115                 120                 125             
Ser Phe Val Ala Thr Gly Leu Met Glu Asp Asp Gly Lys Pro Arg Ala
    130                 135                 140                 
Pro Gln Ala Pro Leu His Ser Val Val Gln Gln Leu His Gly Lys Asn
145                 150                 155                 160 
Leu Val Phe Ser Asp Gly Tyr Val Val Lys Glu Thr Ile Gly Val Gly
                165                 170                 175     
Ser Tyr Ser Glu Cys Lys Arg Cys Val His Lys Ala Thr Asn Met Glu
            180                 185                 190         
Tyr Ala Val Lys Val Ile Asp Lys Ser Lys Arg Asp Pro Ser Glu Glu
        195                 200                 205             
Ile Glu Ile Leu Leu Arg Tyr Gly Gln His Pro Asn Ile Ile Thr Leu
    210                 215                 220                 
Lys Asp Val Tyr Asp Asp Gly Lys His Val Tyr Leu Val Thr Glu Leu
225                 230                 235                 240 
Met Arg Gly Gly Glu Leu Leu Asp Lys Ile Leu Arg Gln Lys Phe Phe
                245                 250                 255     
Ser Glu Arg Glu Ala Ser Phe Val Leu His Thr Ile Gly Lys Thr Val
            260                 265                 270         
Glu Tyr Leu His Ser Gln Gly Val Val His Arg Asp Leu Lys Pro Ser
        275                 280                 285             
Asn Ile Leu Tyr Val Asp Glu Ser Gly Asn Pro Glu Cys Leu Arg Ile
    290                 295                 300                 
Cys Asp Phe Gly Phe Ala Lys Gln Leu Arg Ala Glu Asn Gly Leu Leu
305                 310                 315                 320 
Met Thr Pro Cys Tyr Thr Ala Asn Phe Val Ala Pro Glu Val Leu Lys
                325                 330                 335     
Arg Gln Gly Tyr Asp Glu Gly Cys Asp Ile Trp Ser Leu Gly Ile Leu
            340                 345                 350         
Leu Tyr Thr Met Leu Ala Gly Tyr Thr Pro Phe Ala Asn Gly Pro Ser
        355                 360                 365             
Asp Thr Pro Glu Glu Ile Leu Thr Arg Ile Gly Ser Gly Lys Phe Thr
    370                 375                 380                 
Leu Ser Gly Gly Asn Trp Asn Thr Val Ser Glu Thr Ala Lys Asp Leu
385                 390                 395                 400 
Val Ser Lys Met Leu His Val Asp Pro His Gln Arg Leu Thr Ala Lys
                405                 410                 415     
Gln Val Leu Gln His Pro Trp Val Thr Gln Lys Asp Lys Leu Pro Gln
            420                 425                 430         
Ser Gln Leu Ser His Gln Asp Leu Gln Leu Val Lys Gly Ala Met Ala
        435                 440                 445             
Ala Thr Tyr Ser Ala Leu Asn Ser Ser Lys Pro Thr Pro Gln Leu Lys
    450                 455                 460                 
Pro Ile Glu Ser Ser Ile Leu Ala Gln Arg Arg Val Arg Lys Leu Pro
465                 470                 475                 480 
Ser Thr Thr Leu
                


<210> 1219
<211> 400
<212> PRT
<213> Homo sapiens

<400> 1219
Met Thr Thr Lys Asn Leu Glu Thr Lys Val Thr Val Thr Ser Ser Pro
 1               5                  10                  15      
Ile Arg Gly Ala Gly Asp Gly Met Glu Thr Glu Glu Pro Pro Lys Ser
            20                  25                  30          
Val Glu Val Thr Ser Gly Val Gln Ser Arg Lys His His Ser Leu Gln
        35                  40                  45              
Ser Pro Trp Lys Lys Ala Val Pro Ser Glu Ser Pro Gly Val Leu Gln
    50                  55                  60                  
Leu Gly Lys Met Leu Thr Glu Lys Ala Met Glu Val Lys Ala Val Arg
65                  70                  75                  80  
Ile Leu Val Pro Lys Ala Ala Ile Thr His Asp Ile Pro Asn Lys Asn
                85                  90                  95      
Thr Lys Val Lys Ser Leu Gly His His Lys Gly Glu Phe Leu Gly Gln
            100                 105                 110         
Ser Glu Gly Val Ile Glu Pro Asn Lys Glu Leu Ser Glu Val Lys Asn
        115                 120                 125             
Val Leu Glu Lys Leu Lys Asn Ser Glu Arg Arg Leu Leu Gln Asp Lys
    130                 135                 140                 
Glu Gly Leu Ser Asn Gln Leu Arg Val Gln Thr Glu Val Asn Arg Glu
145                 150                 155                 160 
Leu Lys Lys Leu Leu Val Ala Ser Val Gly Asp Asp Leu Gln Tyr His
                165                 170                 175     
Phe Glu Arg Leu Ala Arg Glu Lys Asn Gln Leu Ile Leu Glu Asn Glu
            180                 185                 190         
Ala Leu Gly Arg Asn Thr Ala Gln Leu Ser Glu Gln Leu Glu Arg Met
        195                 200                 205             
Ser Ile Gln Cys Asp Val Trp Arg Ser Lys Phe Leu Ala Ser Arg Val
    210                 215                 220                 
Met Ala Asp Glu Leu Thr Asn Ser Arg Ala Ala Leu Gln Arg Gln Asn
225                 230                 235                 240 
Arg Asp Ala His Gly Ala Ile Gln Asp Leu Leu Ser Glu Arg Glu Gln
                245                 250                 255     
Phe Arg Gln Glu Met Ile Ala Thr Gln Lys Leu Leu Glu Glu Leu Leu
            260                 265                 270         
Val Ser Leu Gln Trp Gly Arg Glu Gln Thr Tyr Ser Pro Ser Val Gln
        275                 280                 285             
Pro His Ser Thr Ala Glu Leu Ala Leu Thr Asn His Lys Leu Ala Lys
    290                 295                 300                 
Ala Val Asn Ser His Leu Leu Gly Asn Val Gly Ile Asn Asn Gln Lys
305                 310                 315                 320 
Lys Ile Ala Ser Thr Val Glu Phe Cys Ser Thr Pro Ala Glu Lys Met
                325                 330                 335     
Ala Glu Thr Val Leu Arg Ile Leu Asp Pro Val Thr Cys Lys Glu Ser
            340                 345                 350         
Ser Pro Asp Asn Pro Phe Phe Glu Ser Ser Pro Thr Thr Leu Leu Ala
        355                 360                 365             
Thr Lys Lys Asn Ile Gly Arg Phe His Pro Tyr Thr Arg Tyr Glu Asn
    370                 375                 380                 
Ile Thr Phe Asn Cys Cys Asn His Cys Arg Gly Glu Leu Ile Ala Leu
385                 390                 395                 400 


<210> 1220
<211> 295
<212> PRT
<213> Homo sapiens

<400> 1220
Met Asp Asn Ser Gly Lys Glu Ala Glu Ala Met Ala Leu Leu Ala Glu
 1               5                  10                  15      
Ala Glu Arg Lys Val Lys Asn Ser Gln Ser Phe Phe Ser Gly Leu Phe
            20                  25                  30          
Gly Gly Ser Ser Lys Ile Glu Glu Ala Cys Glu Ile Tyr Ala Arg Ala
        35                  40                  45              
Ala Asn Met Phe Lys Met Ala Lys Asn Trp Ser Ala Ala Gly Asn Ala
    50                  55                  60                  
Phe Cys Gln Ala Ala Gln Leu His Leu Gln Leu Gln Ser Lys His Asp
65                  70                  75                  80  
Ala Ala Thr Cys Phe Val Asp Ala Gly Asn Ala Phe Lys Lys Ala Asp
                85                  90                  95      
Pro Gln Glu Ala Ile Asn Cys Leu Met Arg Ala Ile Glu Ile Tyr Thr
            100                 105                 110         
Asp Met Gly Arg Phe Thr Ile Ala Ala Lys His His Ile Ser Ile Ala
        115                 120                 125             
Glu Ile Tyr Glu Thr Glu Leu Val Asp Ile Glu Lys Ala Ile Ala His
    130                 135                 140                 
Tyr Glu Gln Ser Ala Asp Tyr Tyr Lys Gly Glu Glu Ser Asn Ser Ser
145                 150                 155                 160 
Ala Asn Lys Cys Leu Leu Lys Val Ala Gly Tyr Ala Ala Leu Leu Glu
                165                 170                 175     
Gln Tyr Gln Lys Ala Ile Asp Ile Tyr Glu Gln Val Gly Thr Asn Ala
            180                 185                 190         
Met Asp Ser Pro Leu Leu Lys Tyr Ser Ala Lys Asp Tyr Phe Phe Lys
        195                 200                 205             
Ala Ala Leu Cys His Phe Cys Ile Asp Met Leu Asn Ala Lys Leu Ala
    210                 215                 220                 
Val Gln Lys Tyr Glu Glu Leu Phe Pro Ala Phe Ser Asp Ser Arg Glu
225                 230                 235                 240 
Cys Lys Leu Met Lys Lys Leu Leu Glu Ala His Glu Glu Gln Asn Val
                245                 250                 255     
Asp Ser Tyr Thr Glu Ser Val Lys Glu Tyr Asp Ser Ile Ser Arg Leu
            260                 265                 270         
Asp Gln Trp Leu Thr Thr Met Leu Leu Arg Ile Lys Lys Thr Ile Gln
        275                 280                 285             
Gly Asp Glu Glu Asp Leu Arg
    290                 295 


<210> 1221
<211> 190
<212> PRT
<213> Homo sapiens

<400> 1221
Met Ala Gly Ser Arg Leu Glu Thr Val Gly Ser Ile Phe Ser Arg Thr
 1               5                  10                  15      
Arg Asp Leu Val Arg Ala Gly Val Leu Lys Glu Lys Pro Leu Trp Phe
            20                  25                  30          
Asp Val Tyr Asp Ala Phe Pro Pro Leu Arg Glu Pro Val Phe Gln Arg
        35                  40                  45              
Pro Arg Val Arg Tyr Gly Lys Ala Lys Ala Pro Ile Gln Asp Ile Trp
    50                  55                  60                  
Tyr His Glu Asp Arg Ile Arg Ala Lys Phe Tyr Ser Val Tyr Gly Ser
65                  70                  75                  80  
Gly Gln Arg Ala Phe Asp Leu Phe Asn Pro Asn Phe Lys Ser Thr Cys
                85                  90                  95      
Gln Arg Phe Val Glu Lys Tyr Thr Glu Leu Gln Lys Leu Gly Glu Thr
            100                 105                 110         
Asp Glu Glu Lys Leu Phe Val Glu Thr Gly Lys Ala Leu Leu Ala Glu
        115                 120                 125             
Gly Val Ile Leu Arg Arg Val Gly Glu Ala Arg Thr Gln His Gly Gly
    130                 135                 140                 
Ser His Val Ser Arg Lys Ser Glu His Leu Ser Val Arg Pro Gln Thr
145                 150                 155                 160 
Ala Leu Glu Glu Asn Glu Thr Gln Lys Glu Val Pro Gln Asp Gln His
                165                 170                 175     
Leu Glu Ala Pro Ala Asp Gln Ser Lys Gly Leu Leu Pro Pro
            180                 185                 190 


<210> 1222
<211> 916
<212> PRT
<213> Homo sapiens

<400> 1222
Met Ser Tyr Thr Leu Asp Ser Leu Gly Asn Pro Ser Ala Tyr Arg Arg
 1               5                  10                  15      
Val Thr Glu Thr Arg Ser Ser Phe Ser Arg Val Ser Gly Ser Pro Ser
            20                  25                  30          
Ser Gly Phe Arg Ser Gln Ser Trp Ser Arg Gly Ser Pro Ser Thr Val
        35                  40                  45              
Ser Ser Ser Tyr Lys Arg Ser Met Leu Ala Pro Arg Leu Ala Tyr Ser
    50                  55                  60                  
Ser Ala Met Leu Ser Ser Ala Glu Ser Ser Leu Asp Phe Ser Gln Ser
65                  70                  75                  80  
Ser Ser Leu Leu Asn Gly Gly Ser Gly Pro Gly Gly Asp Tyr Lys Leu
                85                  90                  95      
Ser Arg Ser Asn Glu Lys Glu Gln Leu Gln Gly Leu Asn Asp Arg Phe
            100                 105                 110         
Ala Gly Tyr Ile Glu Lys Val His Tyr Leu Glu Gln Gln Asn Lys Glu
        115                 120                 125             
Ile Glu Ala Glu Ile Gln Ala Leu Arg Gln Lys Gln Ala Ser His Ala
    130                 135                 140                 
Gln Leu Gly Asp Ala Tyr Asp Gln Glu Ile Arg Glu Leu Arg Ala Thr
145                 150                 155                 160 
Leu Glu Met Val Asn His Glu Lys Ala Gln Val Gln Leu Asp Ser Asp
                165                 170                 175     
His Leu Glu Glu Asp Ile His Arg Leu Lys Glu Arg Phe Glu Glu Glu
            180                 185                 190         
Ala Arg Leu Arg Asp Asp Thr Glu Ala Ala Ile Arg Ala Leu Arg Lys
        195                 200                 205             
Asp Ile Glu Glu Ala Ser Leu Val Lys Val Glu Leu Asp Lys Lys Val
    210                 215                 220                 
Gln Ser Leu Gln Asp Glu Val Ala Phe Leu Arg Ser Asn His Glu Glu
225                 230                 235                 240 
Glu Val Ala Asp Leu Leu Ala Gln Ile Gln Ala Ser His Ile Thr Val
                245                 250                 255     
Glu Arg Lys Asp Tyr Leu Lys Thr Asp Ile Ser Thr Ala Leu Lys Glu
            260                 265                 270         
Ile Arg Ser Gln Leu Glu Ser His Ser Asp Gln Asn Met His Gln Ala
        275                 280                 285             
Glu Glu Trp Phe Lys Cys Arg Tyr Ala Lys Leu Thr Glu Ala Ala Glu
    290                 295                 300                 
Gln Asn Lys Glu Ala Ile Arg Ser Ala Lys Glu Glu Ile Ala Glu Tyr
305                 310                 315                 320 
Arg Arg Gln Leu Gln Ser Lys Ser Ile Glu Leu Glu Ser Val Arg Gly
                325                 330                 335     
Thr Lys Glu Ser Leu Glu Arg Gln Leu Ser Asp Ile Glu Glu Arg His
            340                 345                 350         
Asn His Asp Leu Ser Ser Tyr Gln Asp Thr Ile Gln Gln Leu Glu Asn
        355                 360                 365             
Glu Leu Arg Gly Thr Lys Trp Glu Met Ala Arg His Leu Arg Glu Tyr
    370                 375                 380                 
Gln Asp Leu Leu Asn Val Lys Met Ala Leu Asp Ile Glu Ile Ala Ala
385                 390                 395                 400 
Tyr Arg Lys Leu Leu Glu Gly Glu Glu Thr Arg Phe Ser Thr Phe Ala
                405                 410                 415     
Gly Ser Ile Thr Gly Pro Leu Tyr Thr His Arg Pro Pro Ile Thr Ile
            420                 425                 430         
Ser Ser Lys Ile Gln Lys Pro Lys Val Glu Ala Pro Lys Leu Lys Val
        435                 440                 445             
Gln His Lys Phe Val Glu Glu Ile Ile Glu Glu Thr Lys Val Glu Asp
    450                 455                 460                 
Glu Lys Ser Glu Met Glu Glu Ala Leu Thr Ala Ile Thr Glu Glu Leu
465                 470                 475                 480 
Ala Val Ser Met Lys Glu Glu Lys Lys Glu Ala Ala Glu Glu Lys Glu
                485                 490                 495     
Glu Glu Pro Glu Ala Glu Glu Glu Glu Val Ala Ala Lys Lys Ser Pro
            500                 505                 510         
Val Lys Ala Thr Ala Pro Glu Val Lys Glu Glu Glu Gly Glu Lys Glu
        515                 520                 525             
Glu Glu Glu Gly Gln Glu Glu Glu Glu Glu Glu Asp Glu Gly Ala Lys
    530                 535                 540                 
Ser Asp Gln Ala Glu Glu Gly Gly Ser Glu Lys Glu Gly Ser Ser Glu
545                 550                 555                 560 
Lys Glu Glu Gly Glu Gln Glu Glu Gly Glu Thr Glu Ala Glu Ala Glu
                565                 570                 575     
Gly Glu Glu Ala Glu Ala Lys Glu Glu Lys Lys Val Glu Glu Lys Ser
            580                 585                 590         
Glu Glu Val Ala Thr Lys Glu Glu Leu Val Ala Asp Ala Lys Val Glu
        595                 600                 605             
Lys Pro Glu Lys Ala Lys Ser Pro Val Pro Lys Ser Pro Val Glu Glu
    610                 615                 620                 
Lys Gly Lys Ser Pro Val Pro Lys Ser Pro Val Glu Glu Lys Gly Lys
625                 630                 635                 640 
Ser Pro Val Pro Lys Ser Pro Val Glu Glu Lys Gly Lys Ser Pro Val
                645                 650                 655     
Pro Lys Ser Pro Val Glu Glu Lys Gly Lys Ser Pro Val Ser Lys Ser
            660                 665                 670         
Pro Val Glu Glu Lys Ala Lys Ser Pro Val Pro Lys Ser Pro Val Glu
        675                 680                 685             
Glu Ala Lys Ser Lys Ala Glu Val Gly Lys Gly Glu Gln Lys Glu Glu
    690                 695                 700                 
Glu Glu Lys Glu Val Lys Glu Ala Pro Lys Glu Glu Lys Val Glu Lys
705                 710                 715                 720 
Lys Glu Glu Lys Pro Lys Asp Val Pro Glu Lys Lys Lys Ala Glu Ser
                725                 730                 735     
Pro Val Lys Glu Glu Ala Val Ala Glu Val Val Thr Ile Thr Lys Ser
            740                 745                 750         
Val Lys Val His Leu Glu Lys Glu Thr Lys Glu Glu Gly Lys Pro Leu
        755                 760                 765             
Gln Gln Glu Lys Glu Lys Glu Lys Ala Gly Gly Glu Gly Gly Ser Glu
    770                 775                 780                 
Glu Glu Gly Ser Asp Lys Gly Ala Lys Gly Ser Arg Lys Glu Asp Ile
785                 790                 795                 800 
Ala Val Asn Gly Glu Val Glu Gly Lys Glu Glu Val Glu Gln Glu Thr
                805                 810                 815     
Lys Glu Lys Gly Ser Gly Arg Glu Glu Glu Lys Gly Val Val Thr Asn
            820                 825                 830         
Gly Leu Asp Leu Ser Pro Ala Asp Glu Lys Lys Gly Gly Asp Lys Ser
        835                 840                 845             
Glu Glu Lys Val Val Val Thr Lys Thr Val Glu Lys Ile Thr Ser Glu
    850                 855                 860                 
Gly Gly Asp Gly Ala Thr Lys Tyr Ile Thr Lys Ser Val Thr Val Thr
865                 870                 875                 880 
Gln Lys Val Glu Glu His Glu Glu Thr Phe Glu Glu Lys Leu Val Ser
                885                 890                 895     
Thr Lys Lys Val Glu Lys Val Thr Ser His Ala Ile Val Lys Glu Val
            900                 905                 910         
Thr Gln Ser Asp
        915     


<210> 1223
<211> 578
<212> PRT
<213> Homo sapiens

<400> 1223
Met Asn Ile Ser Val Asp Leu Glu Thr Asn Tyr Ala Glu Leu Val Leu
 1               5                  10                  15      
Asp Val Gly Arg Val Thr Leu Gly Glu Asn Ser Arg Lys Lys Met Lys
            20                  25                  30          
Asp Cys Lys Leu Arg Lys Lys Gln Asn Glu Arg Val Ser Arg Ala Met
        35                  40                  45              
Cys Ala Leu Leu Asn Ser Gly Gly Gly Val Ile Lys Ala Glu Ile Glu
    50                  55                  60                  
Asn Glu Asp Tyr Ser Tyr Thr Lys Asp Gly Ile Gly Leu Asp Leu Glu
65                  70                  75                  80  
Asn Ser Phe Ser Asn Ile Leu Leu Phe Val Pro Glu Tyr Leu Asp Phe
                85                  90                  95      
Met Gln Asn Gly Asn Tyr Phe Leu Ile Phe Val Lys Ser Trp Ser Leu
            100                 105                 110         
Asn Thr Ser Gly Leu Arg Ile Thr Thr Leu Ser Ser Asn Leu Tyr Lys
        115                 120                 125             
Arg Asp Ile Thr Ser Ala Lys Val Met Asn Ala Thr Ala Ala Leu Glu
    130                 135                 140                 
Phe Leu Lys Asp Met Lys Lys Thr Arg Gly Arg Leu Tyr Leu Arg Pro
145                 150                 155                 160 
Glu Leu Leu Ala Lys Arg Pro Arg Val Asp Ile Gln Glu Glu Asn Asn
                165                 170                 175     
Met Lys Ala Leu Ala Gly Val Phe Phe Asp Arg Thr Glu Leu Asp Arg
            180                 185                 190         
Lys Glu Lys Leu Thr Phe Thr Glu Ser Thr His Val Glu Ile Lys Asn
        195                 200                 205             
Phe Ser Thr Glu Lys Leu Leu Gln Arg Ile Lys Glu Ile Leu Pro Gln
    210                 215                 220                 
Tyr Val Ser Ala Phe Ala Asn Thr Asp Gly Gly Tyr Leu Phe Ile Gly
225                 230                 235                 240 
Leu Asn Glu Asp Lys Glu Ile Ile Gly Phe Lys Ala Glu Met Ser Asp
                245                 250                 255     
Leu Asp Asp Leu Glu Arg Glu Ile Glu Lys Ser Ile Arg Lys Met Pro
            260                 265                 270         
Val His His Phe Cys Met Glu Lys Lys Lys Ile Asn Tyr Ser Cys Lys
        275                 280                 285             
Phe Leu Gly Val Tyr Asp Lys Gly Ser Leu Cys Gly Tyr Val Cys Ala
    290                 295                 300                 
Leu Arg Val Glu Arg Phe Cys Cys Ala Val Phe Ala Lys Glu Pro Asp
305                 310                 315                 320 
Ser Trp His Val Lys Asp Asn Arg Val Met Gln Leu Thr Arg Lys Glu
                325                 330                 335     
Trp Ile Gln Phe Met Val Glu Ala Glu Pro Lys Phe Ser Ser Ser Tyr
            340                 345                 350         
Glu Glu Val Ile Ser Gln Ile Asn Thr Ser Leu Pro Ala Pro His Ser
        355                 360                 365             
Trp Pro Leu Leu Glu Trp Gln Arg Gln Arg His His Cys Pro Gly Leu
    370                 375                 380                 
Ser Gly Arg Ile Thr Tyr Thr Pro Glu Asn Leu Cys Arg Lys Leu Phe
385                 390                 395                 400 
Leu Gln His Glu Gly Leu Lys Gln Leu Ile Cys Glu Glu Met Asp Ser
                405                 410                 415     
Val Arg Lys Gly Ser Leu Ile Phe Ser Arg Ser Trp Ser Val Asp Leu
            420                 425                 430         
Gly Leu Gln Glu Asn His Lys Val Leu Cys Asp Ala Leu Leu Ile Ser
        435                 440                 445             
Gln Asp Ser Pro Pro Val Leu Tyr Thr Phe His Met Val Gln Asp Glu
    450                 455                 460                 
Glu Phe Lys Gly Tyr Ser Thr Gln Thr Ala Leu Thr Leu Lys Gln Lys
465                 470                 475                 480 
Leu Ala Lys Ile Gly Gly Tyr Thr Lys Lys Val Cys Val Met Thr Lys
                485                 490                 495     
Ile Phe Tyr Leu Ser Pro Glu Gly Met Thr Ser Cys Gln Tyr Asp Leu
            500                 505                 510         
Arg Ser Gln Val Ile Tyr Pro Glu Ser Tyr Tyr Phe Thr Arg Arg Lys
        515                 520                 525             
Tyr Leu Leu Lys Ala Leu Phe Lys Ala Leu Lys Arg Leu Lys Ser Leu
    530                 535                 540                 
Arg Asp Gln Phe Ser Phe Ala Glu Asn Leu Tyr Gln Ile Ile Gly Ile
545                 550                 555                 560 
Asp Cys Phe Gln Lys Asn Asp Lys Lys Met Phe Lys Ser Cys Arg Arg
                565                 570                 575     
Leu Thr
        


<210> 1224
<211> 770
<212> PRT
<213> Homo sapiens

<400> 1224
Met Glu Lys Arg Ala Ala Ala Gly Leu Glu Gly Ala Pro Gly Ala Arg
 1               5                  10                  15      
Ala Gln Leu Ala Val Val Cys Leu Val Asn Ile Phe Leu Thr Gly Arg
            20                  25                  30          
Leu Ser Ser Ala Val Pro Ala Leu Ala Ala Cys Ser Gly Lys Leu Glu
        35                  40                  45              
Gln His Thr Glu Arg Arg Gly Val Ile Tyr Ser Pro Ala Trp Pro Leu
    50                  55                  60                  
Asn Tyr Pro Pro Gly Thr Asn Cys Ser Trp Tyr Ile Gln Gly Asp Arg
65                  70                  75                  80  
Gly Asp Met Ile Thr Ile Ser Phe Arg Asn Phe Asp Val Glu Glu Ser
                85                  90                  95      
His Gln Cys Ser Leu Asp Trp Leu Leu Leu Gly Pro Ala Ala Pro Pro
            100                 105                 110         
Arg Gln Glu Ala Phe Arg Leu Cys Gly Ser Ala Ile Pro Pro Ala Phe
        115                 120                 125             
Ile Ser Ala Arg Asp His Val Trp Ile Phe Phe His Ser Asp Ala Ser
    130                 135                 140                 
Ser Ser Gly Gln Ala Gln Gly Phe Arg Leu Ser Tyr Ile Arg Gly Lys
145                 150                 155                 160 
Leu Gly Gln Ala Ser Cys Gln Ala Asp Glu Phe Arg Cys Asp Asn Gly
                165                 170                 175     
Lys Cys Leu Pro Gly Pro Trp Gln Cys Asn Thr Val Asp Glu Cys Gly
            180                 185                 190         
Asp Gly Ser Asp Glu Gly Asn Cys Ser Ala Pro Ala Ser Glu Pro Pro
        195                 200                 205             
Gly Ser Leu Cys Pro Gly Gly Thr Phe Pro Cys Ser Gly Ala Arg Ser
    210                 215                 220                 
Thr Arg Cys Leu Pro Val Glu Arg Arg Cys Asp Gly Leu Gln Asp Cys
225                 230                 235                 240 
Gly Asp Gly Ser Asp Glu Ala Gly Cys Pro Asp Leu Ala Cys Gly Arg
                245                 250                 255     
Arg Leu Gly Ser Phe Tyr Gly Ser Phe Ala Ser Pro Asp Leu Phe Gly
            260                 265                 270         
Ala Ala Arg Gly Pro Ser Asp Leu His Cys Thr Trp Leu Val Asp Thr
        275                 280                 285             
Gln Asp Ser Arg Arg Val Leu Leu Gln Leu Glu Leu Arg Leu Gly Tyr
    290                 295                 300                 
Asp Asp Tyr Val Gln Val Tyr Glu Gly Leu Gly Glu Arg Gly Asp Arg
305                 310                 315                 320 
Leu Leu Gln Thr Leu Ser Tyr Arg Ser Asn His Arg Pro Val Ser Leu
                325                 330                 335     
Glu Ala Ala Gln Gly Arg Leu Thr Val Ala Tyr His Ala Arg Ala Arg
            340                 345                 350         
Ser Ala Gly His Gly Phe Asn Ala Thr Tyr Gln Val Lys Gly Tyr Cys
        355                 360                 365             
Leu Pro Trp Glu Gln Pro Cys Gly Ser Ser Ser Asp Ser Asp Gly Gly
    370                 375                 380                 
Ser Leu Gly Asp Gln Gly Cys Phe Ser Glu Pro Gln Arg Cys Asp Gly
385                 390                 395                 400 
Trp Trp His Cys Ala Ser Gly Arg Asp Glu Gln Gly Cys Pro Ala Cys
                405                 410                 415     
Pro Pro Asp Gln Tyr Pro Cys Glu Gly Gly Ser Gly Leu Cys Tyr Thr
            420                 425                 430         
Pro Ala Asp Arg Cys Asn Asn Gln Lys Ser Cys Pro Asp Gly Ala Asp
        435                 440                 445             
Glu Lys Asn Cys Phe Ser Cys Gln Pro Gly Thr Phe His Cys Gly Thr
    450                 455                 460                 
Asn Leu Cys Ile Phe Glu Thr Trp Arg Cys Asp Gly Gln Glu Asp Cys
465                 470                 475                 480 
Gln Asp Gly Ser Asp Glu His Gly Cys Leu Ala Ala Val Pro Arg Lys
                485                 490                 495     
Val Ile Thr Ala Ala Leu Ile Gly Ser Leu Val Cys Gly Leu Leu Leu
            500                 505                 510         
Val Ile Ala Leu Gly Cys Ala Phe Lys Leu Tyr Ser Leu Arg Thr Gln
        515                 520                 525             
Glu Tyr Arg Ala Phe Glu Thr Gln Met Thr Arg Leu Glu Ala Glu Phe
    530                 535                 540                 
Val Arg Arg Glu Ala Pro Pro Ser Tyr Gly Gln Leu Ile Ala Gln Gly
545                 550                 555                 560 
Leu Ile Pro Pro Val Glu Asp Phe Pro Val Tyr Ser Ala Ser Gln Ala
                565                 570                 575     
Ser Val Leu Gln Asn Leu Arg Thr Ala Met Arg Arg Gln Met Arg Arg
            580                 585                 590         
His Ala Ser Arg Arg Gly Pro Ser Arg Arg Arg Leu Gly Arg Leu Trp
        595                 600                 605             
Asn Arg Leu Phe His Arg Pro Arg Ala Pro Arg Gly Gln Ile Pro Leu
    610                 615                 620                 
Leu Thr Ala Ala Arg Pro Ser Gln Thr Val Leu Gly Asp Gly Phe Leu
625                 630                 635                 640 
Gln Pro Ala Pro Gly Ala Ala Pro Asp Pro Pro Ala Pro Leu Met Asp
                645                 650                 655     
Thr Gly Ser Thr Arg Ala Ala Gly Asp Arg Pro Pro Ser Ala Pro Gly
            660                 665                 670         
Arg Ala Pro Glu Val Gly Pro Ser Gly Pro Pro Leu Pro Ser Gly Leu
        675                 680                 685             
Arg Asp Pro Glu Cys Arg Pro Val Asp Lys Asp Arg Lys Val Cys Arg
    690                 695                 700                 
Glu Pro Leu Val Asp Gly Pro Ala Pro Ala Asp Ala Pro Arg Glu Pro
705                 710                 715                 720 
Cys Ser Ala Gln Asp Pro His Pro Gln Val Ser Thr Ala Ser Ser Thr
                725                 730                 735     
Leu Gly Pro His Ser Pro Glu Pro Leu Gly Val Cys Arg Asn Pro Pro
            740                 745                 750         
Pro Pro Cys Ser Pro Met Leu Glu Ala Ser Asp Asp Glu Ala Leu Leu
        755                 760                 765             
Val Cys
    770 


<210> 1225
<211> 583
<212> PRT
<213> Homo sapiens

<400> 1225
Met Ser Asp Asn Pro Pro Arg Met Glu Val Cys Pro Tyr Cys Lys Lys
 1               5                  10                  15      
Pro Phe Lys Arg Leu Lys Ser His Leu Pro Tyr Cys Lys Met Ile Gly
            20                  25                  30          
Pro Thr Ile Pro Thr Asp Gln Lys Val Tyr Gln Ser Lys Pro Ala Thr
        35                  40                  45              
Leu Pro Arg Ala Lys Lys Met Lys Gly Pro Ile Lys Asp Leu Ile Lys
    50                  55                  60                  
Ala Lys Gly Lys Glu Leu Glu Thr Glu Asn Glu Glu Arg Asn Ser Lys
65                  70                  75                  80  
Leu Val Val Asp Lys Pro Glu Gln Thr Val Lys Thr Phe Pro Leu Pro
                85                  90                  95      
Ala Val Gly Leu Glu Arg Ala Ala Thr Thr Lys Ala Asp Lys Asp Ile
            100                 105                 110         
Lys Asn Pro Ile Gln Pro Ser Phe Lys Met Leu Lys Asn Thr Lys Pro
        115                 120                 125             
Met Thr Thr Phe Gln Glu Glu Thr Lys Ala Gln Phe Tyr Ala Ser Glu
    130                 135                 140                 
Lys Thr Ser Pro Lys Arg Glu Leu Ala Lys Asp Leu Pro Lys Ser Gly
145                 150                 155                 160 
Glu Ser Arg Cys Asn Pro Ser Glu Ala Gly Ala Ser Leu Leu Val Gly
                165                 170                 175     
Ser Ile Glu Pro Ser Leu Ser Asn Gln Asp Arg Lys Tyr Ser Ser Thr
            180                 185                 190         
Leu Pro Asn Asp Val Gln Thr Thr Ser Gly Asp Leu Lys Leu Asp Lys
        195                 200                 205             
Ile Asp Pro Gln Arg Gln Glu Leu Leu Val Lys Leu Leu Asp Val Pro
    210                 215                 220                 
Thr Gly Asp Cys His Ile Ser Pro Lys Asn Val Ser Asp Gly Val Lys
225                 230                 235                 240 
Arg Val Arg Thr Leu Leu Ser Asn Glu Arg Asp Ser Lys Gly Arg Asp
                245                 250                 255     
His Leu Ser Gly Val Pro Thr Asp Val Thr Val Thr Glu Thr Pro Glu
            260                 265                 270         
Lys Asn Thr Glu Ser Leu Ile Leu Ser Leu Lys Met Ser Ser Leu Gly
        275                 280                 285             
Lys Ile Gln Val Met Glu Lys Gln Glu Lys Gly Leu Thr Leu Gly Val
    290                 295                 300                 
Glu Thr Cys Gly Ser Lys Gly Asn Ala Glu Lys Ser Met Ser Ala Thr
305                 310                 315                 320 
Glu Lys Gln Glu Arg Thr Val Met Ser His Gly Cys Glu Asn Phe Asn
                325                 330                 335     
Thr Arg Asp Ser Val Thr Gly Lys Glu Ser Gln Gly Glu Arg Pro His
            340                 345                 350         
Leu Ser Leu Phe Ile Pro Arg Glu Thr Thr Tyr Gln Phe His Ser Val
        355                 360                 365             
Ser Gln Ser Ser Ser Gln Ser Leu Ala Ser Leu Ala Thr Thr Phe Leu
    370                 375                 380                 
Gln Glu Lys Lys Ala Glu Ala Gln Asn His His Cys Val Pro Asp Val
385                 390                 395                 400 
Lys Ala Leu Met Glu Ser Pro Glu Gly Gln Leu Ser Leu Glu Pro Lys
                405                 410                 415     
Ser Asp Ser Gln Phe Gln Ala Ser His Thr Gly Cys Gln Ser Pro Leu
            420                 425                 430         
Cys Ser Ala Gln Arg His Thr Pro Gln Ser Pro Phe Thr Asn His Ala
        435                 440                 445             
Ala Ala Ala Gly Arg Lys Thr Leu Arg Ser Cys Met Gly Leu Glu Trp
    450                 455                 460                 
Phe Pro Glu Leu Tyr Pro Gly Tyr Leu Gly Leu Gly Val Leu Pro Gly
465                 470                 475                 480 
Lys Pro Gln Cys Trp Asn Ala Met Thr Gln Lys Pro Gln Leu Ile Ser
                485                 490                 495     
Pro Gln Gly Glu Arg Leu Ser Gln Val Ser Leu Leu Glu Arg Ser Ser
            500                 505                 510         
Thr His Ile Arg Ser Leu Glu Pro Pro Ala Gly Leu Thr Thr Ser Asn
        515                 520                 525             
Phe Ser Leu Met Arg Leu Leu Gly Ala Val Gln Lys Gly Trp Ile Arg
    530                 535                 540                 
Cys Asn Thr Thr Ile Arg Lys Ser Gly Phe Gly Gly Ile Thr Met Leu
545                 550                 555                 560 
Phe Thr Gly Tyr Phe Val Leu Cys Cys Ser Trp Ser Phe Arg Arg Leu
                565                 570                 575     
Lys Leu Gln Arg Trp Arg Lys
            580             


<210> 1226
<211> 215
<212> PRT
<213> Homo sapiens

<400> 1226
Met Ala Thr Ala Pro Tyr Asn Tyr Ser Tyr Ile Phe Lys Tyr Ile Ile
 1               5                  10                  15      
Ile Gly Asp Met Gly Val Gly Lys Ser Cys Leu Leu His Gln Phe Thr
            20                  25                  30          
Glu Lys Lys Phe Met Ala Asp Cys Pro His Thr Ile Gly Val Glu Phe
        35                  40                  45              
Gly Thr Arg Ile Ile Glu Val Ser Gly Gln Lys Ile Lys Leu Gln Ile
    50                  55                  60                  
Trp Asp Thr Ala Gly Gln Glu Arg Phe Arg Ala Val Thr Arg Ser Tyr
65                  70                  75                  80  
Tyr Arg Gly Ala Ala Gly Ala Leu Met Val Tyr Asp Ile Thr Arg Arg
                85                  90                  95      
Ser Thr Tyr Asn His Leu Ser Ser Trp Leu Thr Asp Ala Arg Asn Leu
            100                 105                 110         
Thr Asn Pro Asn Thr Val Ile Ile Leu Ile Gly Asn Lys Ala Asp Leu
        115                 120                 125             
Glu Ala Gln Arg Asp Val Thr Tyr Glu Glu Ala Lys Gln Phe Ala Glu
    130                 135                 140                 
Glu Asn Gly Leu Leu Phe Leu Glu Ala Ser Ala Lys Thr Gly Glu Asn
145                 150                 155                 160 
Val Glu Asp Ala Phe Leu Glu Ala Ala Lys Lys Ile Tyr Gln Asn Ile
                165                 170                 175     
Gln Asp Gly Ser Leu Asp Leu Asn Ala Ala Glu Ser Gly Val Gln His
            180                 185                 190         
Lys Pro Ser Ala Pro Gln Gly Gly Arg Leu Thr Ser Glu Pro Gln Pro
        195                 200                 205             
Gln Arg Glu Gly Cys Gly Cys
    210                 215 


<210> 1227
<211> 517
<212> PRT
<213> Homo sapiens

<400> 1227
Met Leu Arg Phe Leu Ala Pro Arg Leu Leu Ser Leu Gln Gly Arg Thr
 1               5                  10                  15      
Ala Arg Tyr Ser Ser Ala Ala Ala Leu Pro Ser Pro Ile Leu Asn Pro
            20                  25                  30          
Asp Ile Pro Tyr Asn Gln Leu Phe Ile Asn Asn Glu Trp Gln Asp Ala
        35                  40                  45              
Val Ser Lys Lys Thr Phe Pro Thr Val Asn Pro Thr Thr Gly Glu Val
    50                  55                  60                  
Ile Gly His Val Ala Glu Gly Asp Arg Ala Asp Val Asp Arg Ala Val
65                  70                  75                  80  
Lys Ala Ala Arg Glu Ala Phe Arg Leu Gly Ser Pro Trp Arg Arg Met
                85                  90                  95      
Asp Ala Ser Glu Arg Gly Arg Leu Leu Asn Arg Leu Ala Asp Leu Val
            100                 105                 110         
Glu Arg Asp Arg Val Tyr Leu Ala Ser Leu Glu Thr Leu Asp Asn Gly
        115                 120                 125             
Lys Pro Phe Gln Glu Ser Tyr Ala Leu Asp Leu Asp Glu Val Ile Lys
    130                 135                 140                 
Val Tyr Arg Tyr Phe Ala Gly Trp Ala Asp Lys Trp His Gly Lys Thr
145                 150                 155                 160 
Ile Pro Met Asp Gly Gln His Phe Cys Phe Thr Arg His Glu Pro Val
                165                 170                 175     
Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Val Met Gln
            180                 185                 190         
Gly Trp Lys Leu Ala Pro Ala Leu Ala Thr Gly Asn Thr Val Val Met
        195                 200                 205             
Lys Val Ala Glu Gln Thr Pro Leu Ser Ala Leu Tyr Leu Ala Ser Leu
    210                 215                 220                 
Ile Lys Glu Ala Gly Phe Pro Pro Gly Val Val Asn Ile Ile Thr Gly
225                 230                 235                 240 
Tyr Gly Pro Thr Ala Gly Ala Ala Ile Ala Gln His Val Asp Val Asp
                245                 250                 255     
Lys Val Ala Phe Thr Gly Ser Thr Glu Val Gly His Leu Ile Gln Lys
            260                 265                 270         
Ala Ala Gly Asp Ser Asn Leu Lys Arg Val Thr Leu Glu Leu Gly Gly
        275                 280                 285             
Lys Ser Pro Ser Ile Val Leu Ala Asp Ala Asp Met Glu His Ala Val
    290                 295                 300                 
Glu Gln Cys His Glu Ala Leu Phe Phe Asn Met Gly Gln Cys Cys Cys
305                 310                 315                 320 
Ala Gly Ser Arg Thr Phe Val Glu Glu Ser Ile Tyr Asn Glu Phe Leu
                325                 330                 335     
Glu Arg Thr Val Glu Lys Ala Lys Gln Arg Lys Val Gly Asn Pro Phe
            340                 345                 350         
Glu Leu Asp Thr Gln Gln Gly Pro Gln Val Asp Lys Glu Gln Phe Glu
        355                 360                 365             
Arg Val Leu Gly Tyr Ile Gln Leu Gly Gln Lys Glu Gly Ala Lys Leu
    370                 375                 380                 
Leu Cys Gly Gly Glu Arg Phe Gly Glu Arg Gly Phe Phe Ile Lys Pro
385                 390                 395                 400 
Thr Val Phe Gly Gly Val Gln Asp Asp Met Arg Ile Ala Lys Glu Glu
                405                 410                 415     
Ile Phe Gly Pro Val Gln Pro Leu Phe Lys Phe Lys Lys Ile Glu Glu
            420                 425                 430         
Val Val Glu Arg Ala Asn Asn Thr Arg Tyr Gly Leu Ala Ala Ala Val
        435                 440                 445             
Phe Thr Arg Asp Leu Asp Lys Ala Met Tyr Phe Thr Gln Ala Leu Gln
    450                 455                 460                 
Ala Gly Thr Val Trp Val Asn Thr Tyr Asn Ile Val Thr Cys His Thr
465                 470                 475                 480 
Pro Phe Gly Gly Phe Lys Glu Ser Gly Asn Gly Arg Glu Leu Gly Glu
                485                 490                 495     
Asp Gly Leu Lys Ala Tyr Thr Glu Val Lys Thr Val Thr Ile Lys Val
            500                 505                 510         
Pro Gln Lys Asn Ser
        515         


<210> 1228
<211> 1347
<212> PRT
<213> Homo sapiens

<400> 1228
Met Pro Ser Glu Gln Lys Gln Leu Phe Cys Asp Glu Lys Gln Thr Thr
 1               5                  10                  15      
Leu Lys Lys Asp Tyr Asp Val Lys Asn Glu Ile Val Asp Arg Ser Ala
            20                  25                  30          
Pro Lys Pro Lys Ile Ser Gly Ser Ile His Tyr Ala Leu Lys Asn Val
        35                  40                  45              
Lys Ile Asp Leu Pro Lys Ile Asn Ile Pro Asn Glu Val Leu Leu Lys
    50                  55                  60                  
His Glu Val Asp Lys Tyr Arg Lys Leu Phe Gln Ser Lys Gln Gln Thr
65                  70                  75                  80  
Ala Arg Lys Ser Ile Ser Ile Lys Thr Val Ser Cys Val Glu Glu Cys
                85                  90                  95      
Thr Leu Leu His Lys Ser Glu Arg Ala Glu Glu Glu Gly Val Lys Met
            100                 105                 110         
Ser Ala Lys Ile Leu Asn Phe Ser Cys Leu Lys Cys Arg Asp Asn Thr
        115                 120                 125             
Arg Tyr Ser Pro Asn Asp Leu Gln Lys His Phe Gln Met Trp His His
    130                 135                 140                 
Gly Glu Leu Pro Ser Tyr Pro Cys Glu Met Cys Asn Phe Ser Ala Asn
145                 150                 155                 160 
Asp Phe Gln Val Phe Lys Gln His Arg Arg Thr His Arg Ser Thr Leu
                165                 170                 175     
Val Lys Cys Asp Ile Cys Asn Asn Glu Ser Val Tyr Thr Leu Leu Asn
            180                 185                 190         
Leu Thr Lys His Phe Thr Ser Thr His Cys Val Asn Gly Asn Phe Gln
        195                 200                 205             
Cys Glu Lys Cys Lys Phe Ser Thr Gln Asp Val Gly Thr Phe Val Gln
    210                 215                 220                 
His Ile His Arg His Asn Glu Ile His Tyr Lys Cys Gly Lys Cys His
225                 230                 235                 240 
His Val Cys Phe Thr Lys Gly Glu Leu Gln Lys His Leu His Ile His
                245                 250                 255     
Ser Gly Thr Phe Pro Phe Thr Cys Gln Tyr Cys Ser Tyr Gly Ala Thr
            260                 265                 270         
Arg Arg Glu His Leu Val Arg His Val Ile Thr Leu His Lys Glu His
        275                 280                 285             
Leu Tyr Ala Lys Glu Lys Leu Glu Lys Asp Lys Tyr Glu Lys Arg Met
    290                 295                 300                 
Ala Lys Thr Ser Ala Gly Leu Lys Leu Ile Leu Lys Arg Tyr Lys Ile
305                 310                 315                 320 
Gly Ala Ser Arg Lys Thr Phe Trp Lys Arg Lys Lys Ile Asn Ser Gly
                325                 330                 335     
Ser Asp Arg Ser Ile Glu Lys Asn Thr Gln Val Leu Lys Lys Met Asn
            340                 345                 350         
Lys Thr Gln Thr Lys Ser Glu Asp Gln Ser His Val Val Gln Glu His
        355                 360                 365             
Leu Ser Glu Glu Lys Asp Glu Arg Leu His Cys Glu Asn Asn Asp Lys
    370                 375                 380                 
Ala Pro Glu Ser Glu Ser Glu Lys Pro Thr Pro Leu Ser Thr Gly Gln
385                 390                 395                 400 
Gly Asn Arg Ala Glu Glu Gly Pro Asn Ala Ser Ser Gly Phe Met Lys
                405                 410                 415     
Thr Ala Val Leu Gly Pro Thr Leu Lys Asn Val Met Met Lys Asn Asn
            420                 425                 430         
Lys Leu Ala Val Ser Pro Asn Tyr Asn Ala Thr Phe Met Gly Phe Lys
        435                 440                 445             
Met Met Asp Gly Lys Gln His Ile Val Leu Lys Leu Val Pro Ile Lys
    450                 455                 460                 
Gln Asn Val Cys Ser Pro Gly Ser Gln Ser Gly Ala Ala Lys Asp Gly
465                 470                 475                 480 
Thr Ala Asn Leu Gln Pro Gln Thr Leu Asp Thr Asn Gly Phe Leu Thr
                485                 490                 495     
Gly Val Thr Thr Glu Leu Asn Asp Thr Val Tyr Met Lys Ala Ala Thr
            500                 505                 510         
Pro Phe Ser Cys Ser Ser Ser Ile Leu Ser Gly Lys Ala Ser Ser Glu
        515                 520                 525             
Lys Glu Met Thr Leu Ile Ser Gln Arg Asn Asn Met Leu Gln Thr Met
    530                 535                 540                 
Asp Tyr Glu Lys Ser Val Ser Ser Leu Ser Ala Thr Ser Glu Leu Val
545                 550                 555                 560 
Thr Ala Ser Val Asn Leu Thr Thr Lys Phe Glu Thr Arg Asp Asn Val
                565                 570                 575     
Asp Phe Trp Gly Asn His Leu Thr Gln Ser His Pro Glu Val Leu Gly
            580                 585                 590         
Thr Thr Ile Lys Ser Pro Asp Lys Val Asn Cys Val Ala Lys Pro Asn
        595                 600                 605             
Ala Tyr Asn Ser Gly Asp Met His Asn Tyr Cys Ile Asn Tyr Gly Asn
    610                 615                 620                 
Cys Glu Leu Pro Val Glu Ser Ser Asn Gln Gly Ser Leu Pro Phe His
625                 630                 635                 640 
Asn Tyr Ser Lys Val Asn Asn Ser Asn Lys Arg Arg Arg Phe Ser Gly
                645                 650                 655     
Thr Ala Val Tyr Glu Asn Pro Gln Arg Glu Ser Ser Ser Ser Lys Thr
            660                 665                 670         
Val Val Gln Gln Pro Ile Ser Glu Ser Phe Leu Ser Leu Val Arg Gln
        675                 680                 685             
Glu Ser Ser Lys Pro Asp Ser Leu Leu Ala Ser Ile Ser Leu Leu Asn
    690                 695                 700                 
Asp Lys Asp Gly Thr Leu Lys Ala Lys Ser Glu Ile Glu Glu Gln Tyr
705                 710                 715                 720 
Val Leu Glu Lys Gly Gln Asn Ile Asp Gly Gln Asn Leu Tyr Ser Asn
                725                 730                 735     
Glu Asn Gln Asn Leu Glu Cys Ala Thr Glu Lys Ser Lys Trp Glu Asp
            740                 745                 750         
Phe Ser Asn Val Asp Ser Pro Met Met Pro Arg Ile Thr Ser Val Phe
        755                 760                 765             
Ser Leu Gln Ser Gln Gln Ala Ser Glu Phe Leu Pro Pro Glu Val Asn
    770                 775                 780                 
Gln Leu Leu Gln Asp Val Leu Lys Ile Lys Pro Asp Val Lys Gln Asp
785                 790                 795                 800 
Ser Ser Asn Thr Pro Asn Lys Gly Leu Pro Leu His Cys Asp Gln Ser
                805                 810                 815     
Phe Gln Lys His Glu Arg Glu Gly Lys Ile Val Glu Ser Ser Lys Asp
            820                 825                 830         
Phe Lys Val Gln Gly Ile Phe Pro Val Pro Pro Gly Ser Val Gly Ile
        835                 840                 845             
Asn Val Pro Thr Asn Asp Leu Asn Leu Lys Phe Gly Lys Glu Lys Gln
    850                 855                 860                 
Val Ser Ser Ile Pro Gln Asp Val Arg Asp Ser Glu Lys Met Pro Arg
865                 870                 875                 880 
Ile Ser Gly Phe Gly Thr Leu Leu Lys Thr Gln Ser Asp Ala Ile Ile
                885                 890                 895     
Thr Gln Gln Leu Val Lys Asp Lys Leu Arg Ala Thr Thr Gln Asn Leu
            900                 905                 910         
Gly Ser Phe Tyr Met Gln Ser Pro Leu Leu Asn Ser Glu Gln Lys Lys
        915                 920                 925             
Thr Ile Ile Val Gln Thr Ser Lys Gly Phe Leu Ile Pro Leu Asn Ile
    930                 935                 940                 
Thr Asn Lys Pro Gly Leu Pro Val Ile Pro Gly Asn Ala Leu Pro Leu
945                 950                 955                 960 
Val Asn Ser Gln Gly Ile Pro Ala Ser Leu Phe Val Asn Lys Lys Pro
                965                 970                 975     
Gly Met Val Leu Thr Leu Asn Asn Gly Lys Leu Glu Gly Val Ser Ala
            980                 985                 990         
Val Lys Thr Glu Gly Ala Pro Ala Arg Gly Thr Val Thr Lys Glu Pro
        995                 1000                1005            
Cys Lys Thr Pro Ile Leu Lys Val Glu Pro Asn Asn Asn Cys Leu Thr
    1010                1015                1020                
Pro Gly Leu Cys Ser Ser Ile Gly Ser Cys Leu Ser Met Lys Ser Ser
1025                1030                1035                1040
Ser Glu Asn Thr Leu Pro Leu Lys Gly Pro Tyr Ile Leu Lys Pro Thr
                1045                1050                1055    
Ser Ser Val Lys Ala Val Leu Ile Pro Asn Met Leu Ser Glu Gln Gln
            1060                1065                1070        
Ser Thr Lys Leu Asn Ile Ser Asp Ser Val Lys Gln Gln Asn Glu Ile
        1075                1080                1085            
Phe Pro Lys Pro Pro Leu Tyr Thr Phe Leu Pro Asp Gly Lys Gln Ala
    1090                1095                1100                
Val Phe Leu Lys Cys Val Met Pro Asn Lys Thr Glu Leu Leu Lys Pro
1105                1110                1115                1120
Lys Leu Val Gln Asn Ser Thr Tyr Gln Asn Ile Gln Pro Lys Lys Pro
                1125                1130                1135    
Glu Gly Thr Pro Gln Arg Ile Leu Leu Lys Ile Phe Asn Pro Val Leu
            1140                1145                1150        
Asn Val Thr Ala Ala Asn Asn Leu Ser Val Ser Asn Ser Ala Ser Ser
        1155                1160                1165            
Leu Gln Lys Asp Asn Val Pro Ser Asn Gln Ile Ile Gly Gly Glu Gln
    1170                1175                1180                
Lys Glu Pro Glu Ser Arg Asp Ala Leu Pro Phe Leu Leu Asp Asp Leu
1185                1190                1195                1200
Met Pro Ala Asn Glu Ile Val Ile Thr Ser Thr Ala Thr Cys Pro Glu
                1205                1210                1215    
Ser Ser Glu Glu Pro Ile Cys Val Ser Asp Cys Ser Glu Ser Arg Val
            1220                1225                1230        
Leu Arg Cys Lys Thr Asn Cys Arg Ile Glu Arg Asn Phe Asn Arg Lys
        1235                1240                1245            
Lys Thr Ser Lys Lys Ile Phe Ser Lys Thr Lys Thr His Gly Ser Lys
    1250                1255                1260                
Asp Ser Glu Thr Ala Phe Val Ser Arg Asn Arg Asn Cys Lys Arg Lys
1265                1270                1275                1280
Cys Arg Asp Ser Tyr Gln Glu Pro Pro Arg Arg Lys Ala Thr Leu His
                1285                1290                1295    
Arg Lys Cys Lys Glu Lys Ala Lys Pro Glu Asp Val Arg Glu Thr Phe
            1300                1305                1310        
Gly Phe Ser Arg Pro Arg Leu Ser Lys Asp Ser Ile Arg Thr Leu Arg
        1315                1320                1325            
Leu Phe Pro Phe Ser Ser Lys Gln Leu Val Lys Cys Leu Gly Glu Thr
    1330                1335                1340                
Asn Gln Leu
1345        


<210> 1229
<211> 811
<212> PRT
<213> Homo sapiens

<400> 1229
Met Glu Ser Glu Val Tyr Asp Thr Pro Glu Asn Ile Val His Gly Ser
 1               5                  10                  15      
Gly Ser Gln Leu Phe Asp His Val Ala Glu Cys Leu Gly Asp Phe Met
            20                  25                  30          
Glu Lys Arg Lys Ile Lys Asp Lys Lys Leu Pro Val Gly Phe Thr Phe
        35                  40                  45              
Ser Phe Pro Cys Gln Gln Ser Lys Ile Asp Glu Ala Ile Leu Ile Thr
    50                  55                  60                  
Trp Thr Lys Arg Phe Lys Ala Ser Gly Val Glu Gly Ala Asp Val Val
65                  70                  75                  80  
Lys Leu Leu Asn Lys Ala Ile Lys Lys Arg Gly Asp Tyr Asp Ala Asn
                85                  90                  95      
Ile Val Ala Val Val Asn Asp Thr Val Gly Thr Met Met Thr Cys Gly
            100                 105                 110         
Tyr Asp Asp Gln His Cys Glu Val Gly Leu Ile Ile Gly Thr Gly Thr
        115                 120                 125             
Asn Ala Cys Tyr Met Glu Glu Leu Arg His Ile Asp Leu Val Glu Gly
    130                 135                 140                 
Asp Glu Gly Arg Met Cys Ile Asn Thr Glu Trp Gly Ala Phe Gly Asp
145                 150                 155                 160 
Asp Gly Ser Leu Glu Asp Ile Arg Thr Glu Phe Asp Arg Glu Ile Asp
                165                 170                 175     
Arg Gly Ser Leu Asn Pro Gly Lys Gln Leu Phe Glu Lys Met Val Ser
            180                 185                 190         
Gly Met Tyr Leu Gly Glu Leu Val Arg Leu Ile Leu Val Lys Met Ala
        195                 200                 205             
Lys Glu Gly Leu Leu Phe Glu Gly Arg Ile Thr Pro Glu Leu Leu Thr
    210                 215                 220                 
Arg Gly Lys Phe Asn Thr Ser Asp Val Ser Ala Ile Glu Lys Asn Lys
225                 230                 235                 240 
Glu Gly Leu His Asn Ala Lys Glu Ile Leu Thr Arg Leu Gly Val Glu
                245                 250                 255     
Pro Ser Asp Asp Asp Cys Val Ser Val Gln His Val Cys Thr Ile Val
            260                 265                 270         
Ser Phe Arg Ser Ala Asn Leu Val Ala Ala Thr Leu Gly Ala Ile Leu
        275                 280                 285             
Asn Arg Leu Arg Asp Asn Lys Gly Thr Pro Arg Leu Arg Thr Thr Val
    290                 295                 300                 
Gly Val Asp Gly Ser Leu Tyr Lys Thr His Pro Gln Tyr Ser Arg Arg
305                 310                 315                 320 
Phe His Lys Thr Leu Arg Arg Leu Val Pro Asp Ser Asp Val Arg Phe
                325                 330                 335     
Leu Leu Ser Glu Ser Gly Ser Gly Lys Gly Ala Ala Met Val Thr Ala
            340                 345                 350         
Val Ala Tyr Arg Leu Ala Glu Gln His Arg Gln Ile Glu Glu Thr Leu
        355                 360                 365             
Ala His Phe His Leu Thr Lys Asp Met Leu Leu Glu Val Lys Lys Arg
    370                 375                 380                 
Met Arg Ala Glu Met Glu Leu Gly Leu Arg Lys Gln Thr His Asn Asn
385                 390                 395                 400 
Ala Val Val Lys Met Leu Pro Ser Phe Val Arg Arg Thr Pro Asp Gly
                405                 410                 415     
Thr Glu Asn Gly Asp Phe Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe
            420                 425                 430         
Arg Val Leu Leu Val Lys Ile Arg Ser Gly Lys Lys Arg Thr Val Glu
        435                 440                 445             
Met His Asn Lys Ile Tyr Ala Ile Pro Ile Glu Ile Met Gln Gly Thr
    450                 455                 460                 
Gly Glu Glu Leu Phe Asp His Ile Val Ser Cys Ile Ser Asp Phe Leu
465                 470                 475                 480 
Asp Tyr Met Gly Ile Lys Gly Pro Arg Met Pro Leu Gly Phe Thr Phe
                485                 490                 495     
Ser Phe Pro Cys Gln Gln Thr Ser Leu Asp Ala Gly Ile Leu Ile Thr
            500                 505                 510         
Trp Thr Lys Gly Phe Lys Ala Thr Asp Cys Val Gly His Asp Val Val
        515                 520                 525             
Thr Leu Leu Arg Asp Ala Ile Lys Arg Arg Glu Glu Phe Asp Leu Asp
    530                 535                 540                 
Val Val Ala Val Val Asn Asp Thr Val Gly Thr Met Met Thr Cys Ala
545                 550                 555                 560 
Tyr Glu Glu Pro Thr Cys Glu Val Gly Leu Ile Val Gly Thr Gly Ser
                565                 570                 575     
Asn Ala Cys Tyr Met Glu Glu Met Lys Asn Val Glu Met Val Glu Gly
            580                 585                 590         
Asp Gln Gly Gln Met Cys Ile Asn Met Glu Trp Gly Ala Phe Gly Asp
        595                 600                 605             
Asn Gly Cys Leu Asp Asp Ile Arg Thr His Tyr Asp Arg Leu Val Asp
    610                 615                 620                 
Glu Tyr Ser Leu Asn Ala Gly Lys Gln Arg Tyr Glu Lys Met Ile Ser
625                 630                 635                 640 
Gly Met Tyr Leu Gly Glu Ile Val Arg Asn Ile Leu Ile Asp Phe Thr
                645                 650                 655     
Lys Lys Gly Phe Leu Phe Arg Gly Gln Ile Ser Glu Thr Leu Lys Thr
            660                 665                 670         
Arg Gly Ile Phe Glu Thr Lys Phe Leu Ser Gln Ile Glu Ser Asp Arg
        675                 680                 685             
Leu Ala Leu Leu Gln Val Arg Ala Ile Leu Gln Gln Leu Gly Leu Asn
    690                 695                 700                 
Ser Thr Cys Asp Asp Ser Ile Leu Val Lys Thr Val Cys Gly Val Val
705                 710                 715                 720 
Ser Arg Arg Ala Ala Gln Leu Cys Gly Ala Gly Met Ala Ala Val Val
                725                 730                 735     
Asp Lys Ile Arg Glu Asn Arg Gly Leu Asp Arg Leu Asn Val Thr Val
            740                 745                 750         
Gly Val Asp Gly Thr Leu Tyr Lys Leu His Pro His Phe Ser Arg Ile
        755                 760                 765             
Met His Gln Thr Val Lys Glu Leu Ser Pro Lys Cys Asn Val Ser Phe
    770                 775                 780                 
Leu Leu Ser Glu Asp Gly Ser Gly Lys Gly Ala Ala Leu Ile Thr Ala
785                 790                 795                 800 
Val Gly Val Arg Leu Arg Thr Glu Ala Ser Ser
                805                 810     


<210> 1230
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1230
Met Leu Arg Ala Pro Gly Cys Leu Leu Arg Thr Ser Val Ala Pro Ala
 1               5                  10                  15      
Ala Ala Leu Ala Ala Ala Leu Leu Ser Ser Leu Ala Arg Cys Ser Leu
            20                  25                  30          
Leu Glu Pro Arg Asp Pro Val Ala Ser Ser Leu Ser Pro Tyr Phe Gly
        35                  40                  45              
Thr Lys Thr Arg Tyr Glu Asp Val Asn Pro Val Leu Leu Ser Gly Pro
    50                  55                  60                  
Glu Ala Pro Trp Arg Asp Pro Glu Leu Leu Glu Gly Thr Cys Thr Pro
65                  70                  75                  80  
Val Gln Leu Val Ala Leu Ile Arg His Gly Thr Arg Tyr Pro Thr Val
                85                  90                  95      
Lys Gln Ile Arg Lys Leu Arg Gln Leu His Gly Leu Leu Gln Ala Arg
            100                 105                 110         
Gly Ser Arg Asp Gly Gly Ala Ser Ser Thr Gly Ser Arg Asp Leu Gly
        115                 120                 125             
Ala Ala Leu Ala Asp Trp Pro Leu Trp Tyr Ala Asp Trp Met Asp Gly
    130                 135                 140                 
Gln Leu Val Glu Lys Gly Arg Gln Asp Met Arg Gln Leu Ala Leu Arg
145                 150                 155                 160 
Leu Ala Ser Leu Phe Pro Ala Leu Phe Ser Arg Glu Asn Tyr Gly Arg
                165                 170                 175     
Leu Arg Leu Ile Thr Ser Ser Lys His Arg Cys Met Asp Ser Ser Ala
            180                 185                 190         
Ala Phe Leu Gln Gly Leu Trp Gln His Tyr His Pro Gly Leu Pro Pro
        195                 200                 205             
Pro Asp Val Ala Asp Met Glu Phe Gly Pro Pro Thr Val Asn Asp Lys
    210                 215                 220                 
Leu Met Arg Phe Phe Asp His Cys Glu Lys Phe Leu Thr Glu Val Glu
225                 230                 235                 240 
Lys Asn Ala Thr Ala Leu Tyr His Val Glu Ala Phe Lys Thr Gly Pro
                245                 250                 255     
Glu Met Gln Asn Ile Leu Lys Lys Val Ala Ala Thr Leu Gln Val Pro
            260                 265                 270         
Val Asn Asp Leu Asn Ala Asp Leu Ile Gln Val Ala Phe Phe Thr Cys
        275                 280                 285             
Ser Phe Asp Leu Ala Ile Lys Gly Val Lys Ser Pro Trp Cys Asp Val
    290                 295                 300                 
Phe Asp Ile Asp Asp Ala Lys Val Leu Glu Tyr Leu Asn Asp Leu Lys
305                 310                 315                 320 
Gln Tyr Trp Lys Arg Gly Tyr Gly Tyr Thr Ile Asn Ser Arg Ser Ser
                325                 330                 335     
Cys Thr Leu Phe Gln Asp Ile Phe Gln His Leu Asp Lys Ala Val Glu
            340                 345                 350         
Gln Lys Gln Arg Ser Gln Pro Ile Ser Ser Pro Val Ile Leu Gln Phe
        355                 360                 365             
Gly His Ala Glu Thr Leu Leu Pro Leu Leu Ser Leu Met Gly Tyr Phe
    370                 375                 380                 
Lys Asp Lys Glu Pro Leu Thr Ala Tyr Asn Tyr Lys Lys Gln Met His
385                 390                 395                 400 
Arg Lys Phe Arg Ser Gly Leu Ile Val Pro Tyr Ala Ser Asn Leu Ile
                405                 410                 415     
Phe Val Leu Tyr His Cys Glu Asn Ala Lys Thr Pro Lys Glu Gln Phe
            420                 425                 430         
Arg Val Gln Met Leu Leu Asn Glu Lys Val Leu Pro Leu Ala Tyr Ser
        435                 440                 445             
Gln Glu Thr Val Ser Phe Tyr Glu Asp Leu Lys Asn His Tyr Lys Asp
    450                 455                 460                 
Ile Leu Gln Ser Cys Gln Thr Ser Glu Glu Cys Glu Leu Ala Arg Ala
465                 470                 475                 480 
Asn Ser Thr Ser Asp Glu Leu
                485         


<210> 1231
<211> 779
<212> PRT
<213> Homo sapiens

<400> 1231
Met Thr His Thr Arg Arg Lys Ser Leu Pro Met Leu Ser Ser Gly Leu
 1               5                  10                  15      
Thr Gly Arg Arg Glu Pro Leu Gln Met Glu Asp Ser Asn Met Glu Gln
            20                  25                  30          
Gly Val Glu Gly Val Glu Pro Gly Met Pro Glu Ser Pro Gly His Leu
        35                  40                  45              
Thr Gly Arg Arg Lys Asn Tyr Pro Leu Arg Lys Arg Pro Leu Val Pro
    50                  55                  60                  
Glu Lys Pro Lys Ala Cys Lys Val Leu Leu Thr Arg Leu Glu Asn Val
65                  70                  75                  80  
Ala Gly Pro Arg Ser Ala Asp Glu Ala Asp Glu Leu Pro Pro Asp Leu
                85                  90                  95      
Pro Lys Pro Pro Ser Pro Ala Pro Ser Ser Glu Asp Pro Gly Leu Ala
            100                 105                 110         
Gln Pro Arg Lys Arg Arg Leu Ala Ser Leu Asn Ala Glu Ala Leu Asn
        115                 120                 125             
Asn Leu Leu Leu Glu Arg Glu Asp Thr Ser Ser Leu Ala Gly Thr Arg
    130                 135                 140                 
Arg Ser Arg Ala Gly Asp Pro His Arg Ser Arg Asp Arg Asp Arg Ala
145                 150                 155                 160 
Thr Gly Gly Trp Ser Ser Ser Lys Lys Arg Pro Arg Leu Gly Asp Leu
                165                 170                 175     
Gly Gly Gly Ser Arg Asp Leu Ser Pro Glu Pro Ala Pro Asp Glu Gly
            180                 185                 190         
Pro Arg Arg Asp Gly Asp Pro Ala Pro Lys Arg Leu Ala Ser Leu Asn
        195                 200                 205             
Ala Ala Ala Phe Leu Lys Leu Ser Gln Glu Arg Glu Leu Pro Leu Arg
    210                 215                 220                 
Leu Pro Arg Ala His Ala Glu Val Asp Gly Arg Ser Thr Glu Pro Pro
225                 230                 235                 240 
Ala Pro Lys Ala Pro Arg Pro Lys Trp Pro Lys Val Asn Gly Lys Asn
                245                 250                 255     
Tyr Pro Lys Ala Trp Gln Gly Ala Ser Ser Gly Glu Ala Ala Gly Pro
            260                 265                 270         
Pro Gly Trp Gln Gly Cys Pro Asp Glu Pro Trp Pro Ser Ala Thr Pro
        275                 280                 285             
Cys Gly Pro Ser Val Gln Pro Ser His Gln Pro Leu Ser Lys Ala Leu
    290                 295                 300                 
Glu Ser Pro Leu Gly Leu Arg Pro His Leu Pro Leu Leu Met Gly Gly
305                 310                 315                 320 
Gln Ala Ala Leu Lys Pro Glu Pro Gly Arg Pro Gly Glu Glu Ser Pro
                325                 330                 335     
Ala Pro Lys Gln Glu Leu His Gln Pro Ser Phe Pro Thr Pro Gln Leu
            340                 345                 350         
Ser Pro Leu Pro Met Pro Gly Asn Pro Ala Asp Tyr Asn Gly Leu Cys
        355                 360                 365             
Val Gly Pro Glu Leu Thr Ala Leu Gly Ser Phe Tyr Leu Tyr Cys Gly
    370                 375                 380                 
Gln Glu Gly Leu Gln Cys Gly Gly Tyr Ser Pro Cys Pro Met Leu Pro
385                 390                 395                 400 
Glu Gly Lys Leu Ser Pro Val Ala Ala Pro His Glu Glu Gly Leu Leu
                405                 410                 415     
Leu Ala Pro Ser Ser Val Pro Ser Gly Thr Pro Phe Gln His Pro Pro
            420                 425                 430         
Trp Gly Ser Ser Arg Tyr Cys Ser Ser Glu Asp Thr Gly Val Asn Gly
        435                 440                 445             
Tyr Ser Ile Cys Gly Val Leu Pro Leu Ser Val Thr His Ala Gly Thr
    450                 455                 460                 
Thr Cys Gly Gly Cys Pro Tyr Lys Met Pro Phe Ala Ala Gly Cys Arg
465                 470                 475                 480 
Ser Leu Gly Gln Leu Glu Phe Pro Leu Pro Glu Ala Gly His Pro Ala
                485                 490                 495     
Ser Pro Ala His Pro Leu Leu Gly Cys Pro Val Pro Ser Val Pro Pro
            500                 505                 510         
Ala Ala Glu Pro Val Pro His Leu Gln Thr Pro Thr Ser Glu Pro Gln
        515                 520                 525             
Thr Val Ala Arg Ala Cys Pro Gln Ser Ala Lys Pro Pro Ser Gly Ser
    530                 535                 540                 
Lys Ser Gly Leu Arg Thr Gly Ser Ser Cys Arg His Thr Ala Arg Ser
545                 550                 555                 560 
Lys Ala Ala Arg Arg Pro Ser His Pro Lys Gln Pro Arg Val Gln Arg
                565                 570                 575     
Pro Arg Pro Arg Arg Arg Arg Arg Arg Arg Thr Asn Gly Trp Val Pro
            580                 585                 590         
Val Gly Ala Ala Cys Glu Lys Ala Val Tyr Val Leu Asp Glu Pro Glu
        595                 600                 605             
Pro Ala Ile Arg Lys Ser Tyr Gln Ala Val Glu Arg His Gly Glu Thr
    610                 615                 620                 
Ile Arg Val Arg Asp Thr Val Leu Leu Lys Ser Gly Pro Arg Lys Thr
625                 630                 635                 640 
Ser Thr Pro Tyr Val Ala Lys Ile Ser Ala Leu Trp Glu Asn Pro Glu
                645                 650                 655     
Ser Gly Glu Leu Met Met Ser Leu Leu Trp Tyr Tyr Arg Pro Glu His
            660                 665                 670         
Leu Gln Gly Gly Arg Ser Pro Ser Met His Glu Pro Leu Gln Asn Glu
        675                 680                 685             
Val Phe Ala Ser Arg His Gln Asp Gln Asn Ser Val Ala Cys Ile Glu
    690                 695                 700                 
Glu Lys Cys Tyr Val Leu Thr Phe Ala Glu Tyr Cys Arg Phe Cys Ala
705                 710                 715                 720 
Met Ala Lys Arg Arg Gly Glu Gly Leu Pro Ser Arg Lys Thr Ala Leu
                725                 730                 735     
Val Pro Pro Ser Ala Asp Tyr Ser Thr Pro Pro His Arg Thr Val Pro
            740                 745                 750         
Glu Asp Thr Asp Pro Glu Leu Val Phe Leu Cys Arg His Val Tyr Asp
        755                 760                 765             
Phe Arg His Gly Arg Ile Leu Lys Asn Pro Gln
    770                 775                 


<210> 1232
<211> 991
<212> PRT
<213> Homo sapiens

<400> 1232
Met Glu Glu Tyr Glu Lys Phe Cys Glu Lys Ser Leu Ala Arg Ile Gln
 1               5                  10                  15      
Glu Ala Ser Leu Ser Thr Glu Ser Phe Leu Pro Ala Gln Ser Glu Ser
            20                  25                  30          
Ile Ser Leu Ile Arg Phe His Gly Val Ala Ile Leu Ser Pro Leu Leu
        35                  40                  45              
Asn Ile Glu Lys Arg Lys Glu Met Gln Gln Glu Lys Gln Lys Ala Leu
    50                  55                  60                  
Asp Val Glu Ala Arg Lys Gln Val Asn Arg Lys Lys Ala Leu Leu Thr
65                  70                  75                  80  
Arg Val Gln Glu Ile Leu Asp Asn Val Gln Val Arg Lys Ala Pro Asn
                85                  90                  95      
Ala Ser Asp Phe Asp Gln Trp Glu Met Glu Thr Val Tyr Ser Asn Ser
            100                 105                 110         
Glu Val Arg Asn Leu Asn Val Pro Ala Thr Phe Pro Asn Ser Phe Pro
        115                 120                 125             
Ser His Thr Glu His Ser Thr Ala Ala Lys Leu Asp Lys Ile Ala Gly
    130                 135                 140                 
Ile Leu Pro Leu Asp Asn Glu Asp Gln Cys Lys Thr Asp Gly Ile Asp
145                 150                 155                 160 
Leu Ala Arg Asp Ser Glu Gly Phe Asn Ser Pro Lys Gln Cys Asp Ser
                165                 170                 175     
Ser Asn Ile Ser His Val Glu Asn Glu Ala Phe Pro Lys Thr Ser Ser
            180                 185                 190         
Ala Thr Pro Gln Glu Thr Leu Ile Ser Asp Gly Pro Phe Ser Val Asn
        195                 200                 205             
Glu Gln Gln Asp Leu Pro Leu Leu Ala Glu Val Ile Pro Asp Pro Tyr
    210                 215                 220                 
Val Met Ser Leu Gln Asn Leu Met Lys Lys Ser Lys Glu Tyr Ile Glu
225                 230                 235                 240 
Arg Glu Gln Ser Arg Arg Ser Leu Arg Gly Ser Met Asn Arg Ile Val
                245                 250                 255     
Asn Glu Ser His Leu Asp Lys Glu His Asp Ala Val Glu Val Ala Asp
            260                 265                 270         
Cys Val Lys Glu Lys Gly Gln Leu Thr Gly Lys His Cys Val Ser Val
        275                 280                 285             
Ile Pro Asp Lys Pro Ser Leu Asn Lys Ser Asn Val Leu Leu Gln Gly
    290                 295                 300                 
Ala Ser Thr Gln Ala Ser Ser Met Ser Met Pro Val Leu Ala Ser Phe
305                 310                 315                 320 
Ser Lys Val Asp Ile Pro Ile Arg Thr Gly His Pro Thr Val Leu Glu
                325                 330                 335     
Ser Asn Ser Asp Phe Lys Val Ile Pro Thr Phe Val Thr Glu Asn Asn
            340                 345                 350         
Val Ile Lys Ser Leu Thr Gly Ser Tyr Ala Lys Leu Pro Ser Pro Glu
        355                 360                 365             
Pro Ser Met Ser Pro Lys Met His Arg Arg Arg Ser Arg Thr Ser Ser
    370                 375                 380                 
Ala Cys His Ile Leu Ile Asn Asn Pro Ile Asn Ala Cys Glu Leu Ser
385                 390                 395                 400 
Pro Lys Gly Lys Glu Gln Ala Met Asp Leu Ile Ile Gln Asp Thr Asp
                405                 410                 415     
Glu Asn Thr Asn Val Pro Glu Ile Met Pro Lys Leu Pro Thr Asp Leu
            420                 425                 430         
Ala Gly Val Cys Ser Ser Lys Val Tyr Val Gly Lys Asn Thr Ser Glu
        435                 440                 445             
Val Lys Glu Asp Val Val Leu Gly Lys Ser Asn Gln Val Cys Gln Ser
    450                 455                 460                 
Ser Gly Asn His Leu Glu Asn Lys Val Thr His Gly Leu Val Thr Val
465                 470                 475                 480 
Glu Gly Gln Leu Thr Ser Asp Glu Arg Gly Ala His Ile Met Asn Ser
                485                 490                 495     
Thr Cys Ala Ala Met Pro Lys Leu His Glu Pro Tyr Ala Ser Ser Gln
            500                 505                 510         
Cys Ile Ala Ser Pro Asn Phe Gly Thr Val Ser Gly Leu Lys Pro Ala
        515                 520                 525             
Ser Met Leu Glu Lys Asn Cys Ser Leu Gln Thr Glu Leu Asn Lys Ser
    530                 535                 540                 
Tyr Asp Val Lys Asn Pro Ser Pro Leu Leu Met Gln Asn Gln Asn Thr
545                 550                 555                 560 
Arg Gln Gln Met Asp Thr Pro Met Val Ser Cys Gly Asn Glu Gln Phe
                565                 570                 575     
Leu Asp Asn Ser Phe Glu Lys Val Lys Arg Arg Leu Asp Leu Asp Ile
            580                 585                 590         
Asp Gly Leu Gln Lys Glu Asn Cys Pro Tyr Val Ile Thr Ser Gly Ile
        595                 600                 605             
Thr Glu Gln Glu Arg Gln His Leu Pro Glu Lys Arg Tyr Pro Lys Gly
    610                 615                 620                 
Ser Gly Phe Val Asn Lys Asn Lys Met Leu Gly Thr Ser Ser Lys Glu
625                 630                 635                 640 
Ser Glu Glu Leu Leu Lys Ser Lys Met Leu Ala Phe Glu Glu Met Arg
                645                 650                 655     
Lys Arg Leu Glu Glu Gln His Ala Gln Gln Leu Ser Leu Leu Ile Ala
            660                 665                 670         
Glu Gln Glu Arg Glu Gln Glu Arg Leu Gln Lys Glu Ile Glu Glu Gln
        675                 680                 685             
Glu Lys Met Leu Lys Glu Lys Lys Ala Met Thr Ala Glu Ala Ser Glu
    690                 695                 700                 
Leu Asp Ile Asn Asn Ala Val Glu Leu Glu Trp Arg Lys Ile Ser Asp
705                 710                 715                 720 
Ser Ser Leu Leu Glu Thr Met Leu Ser Gln Ala Asp Ser Leu His Thr
                725                 730                 735     
Ser Asn Ser Asn Ser Ser Gly Phe Thr Asn Ser Ala Met Gln Tyr Ser
            740                 745                 750         
Phe Val Ser Ala Asn Glu Ala Pro Phe Tyr Leu Trp Gly Ser Ser Thr
        755                 760                 765             
Ser Gly Leu Thr Lys Leu Ser Val Thr Arg Pro Phe Gly Arg Ala Lys
    770                 775                 780                 
Thr Arg Trp Ser Gln Val Phe Ser Leu Glu Ile Gln Ala Lys Phe Asn
785                 790                 795                 800 
Lys Ile Thr Ala Val Ala Lys Gly Phe Leu Thr Arg Arg Leu Met Gln
                805                 810                 815     
Thr Asp Lys Leu Lys Gln Leu Arg Gln Thr Val Lys Asp Thr Met Glu
            820                 825                 830         
Phe Ile Arg Ser Phe Gln Ser Glu Ala Pro Leu Lys Arg Gly Ile Val
        835                 840                 845             
Ser Ala Gln Asp Ala Ser Leu Gln Glu Arg Val Leu Ala Gln Leu Arg
    850                 855                 860                 
Ala Ala Leu Tyr Gly Ile His Asp Ile Phe Phe Val Met Asp Ala Ala
865                 870                 875                 880 
Glu Arg Met Ser Ile Leu His His Asp Arg Glu Val Arg Lys Glu Lys
                885                 890                 895     
Met Leu Arg Gln Met Asp Lys Met Lys Ser Pro Arg Val Ala Leu Ser
            900                 905                 910         
Ala Ala Thr Gln Lys Ser Leu Asp Arg Lys Lys Tyr Met Lys Ala Ala
        915                 920                 925             
Glu Met Gly Met Pro Asn Lys Lys Phe Leu Val Lys Gln Asn Pro Ser
    930                 935                 940                 
Glu Thr Arg Val Leu Gln Pro Asn Gln Gly Gln Asn Ala Pro Val His
945                 950                 955                 960 
Arg Leu Leu Ser Arg Gln Gly Ser Ile Cys Arg Lys Asn Pro Lys Lys
                965                 970                 975     
Ala Ala Lys Cys Cys Asp Asn Leu Arg Arg Gln His Ser Leu Gly
            980                 985                 990     


<210> 1233
<211> 439
<212> PRT
<213> Homo sapiens

<400> 1233
Met Ala Asp Pro Asp Val Leu Thr Glu Val Pro Ala Ala Leu Lys Arg
 1               5                  10                  15      
Leu Ala Lys Tyr Val Ile Arg Gly Phe Tyr Gly Ile Glu His Ala Leu
            20                  25                  30          
Ala Leu Asp Ile Leu Ile Arg Asn Ser Cys Val Lys Glu Glu Asp Met
        35                  40                  45              
Leu Glu Leu Leu Lys Phe Asp Arg Lys Gln Leu Arg Ser Val Leu Asn
    50                  55                  60                  
Asn Leu Lys Gly Asp Lys Phe Ile Lys Cys Arg Met Arg Val Glu Thr
65                  70                  75                  80  
Ala Ala Asp Gly Lys Thr Thr Arg His Asn Tyr Tyr Phe Ile Asn Tyr
                85                  90                  95      
Arg Thr Leu Val Asn Val Val Lys Tyr Lys Leu Asp His Met Arg Arg
            100                 105                 110         
Arg Ile Glu Thr Asp Glu Arg Asp Ser Thr Asn Arg Ala Ser Phe Lys
        115                 120                 125             
Cys Pro Val Cys Ser Ser Thr Phe Thr Asp Leu Glu Ala Asn Gln Leu
    130                 135                 140                 
Phe Asp Pro Met Thr Gly Thr Phe Arg Cys Thr Phe Cys His Thr Glu
145                 150                 155                 160 
Val Glu Glu Asp Glu Ser Ala Met Pro Lys Lys Asp Ala Arg Thr Leu
                165                 170                 175     
Leu Ala Arg Phe Asn Glu Gln Ile Glu Pro Ile Tyr Ala Leu Leu Arg
            180                 185                 190         
Glu Thr Glu Asp Val Asn Leu Ala Tyr Glu Ile Leu Glu Pro Glu Pro
        195                 200                 205             
Thr Glu Ile Pro Ala Leu Lys Gln Ser Lys Asp His Ala Ala Thr Thr
    210                 215                 220                 
Ala Gly Ala Ala Ser Leu Ala Gly Gly His His Arg Glu Ala Trp Ala
225                 230                 235                 240 
Thr Lys Gly Pro Ser Tyr Glu Asp Leu Tyr Thr Gln Asn Val Val Ile
                245                 250                 255     
Asn Met Asp Asp Gln Glu Asp Leu His Arg Ala Ser Leu Glu Gly Lys
            260                 265                 270         
Ser Ala Lys Glu Arg Pro Ile Trp Leu Arg Glu Ser Thr Val Gln Gly
        275                 280                 285             
Ala Tyr Gly Ser Glu Asp Met Lys Glu Gly Gly Ile Asp Met Asp Ala
    290                 295                 300                 
Phe Gln Glu Arg Glu Glu Gly His Ala Gly Pro Asp Asp Asn Glu Glu
305                 310                 315                 320 
Val Met Arg Ala Leu Leu Ile His Glu Lys Lys Thr Ser Ser Ala Met
                325                 330                 335     
Ala Gly Ser Val Gly Ala Ala Ala Pro Val Thr Ala Ala Asn Gly Ser
            340                 345                 350         
Asp Ser Glu Ser Glu Thr Ser Glu Ser Asp Asp Asp Ser Pro Pro Arg
        355                 360                 365             
Pro Ala Ala Val Ala Val His Lys Arg Glu Glu Asp Glu Glu Glu Asp
    370                 375                 380                 
Asp Glu Phe Glu Glu Val Ala Asp Asp Pro Ile Val Met Val Ala Gly
385                 390                 395                 400 
Arg Pro Phe Ser Tyr Ser Glu Val Ser Gln Arg Pro Glu Leu Val Ala
                405                 410                 415     
Gln Met Thr Pro Glu Glu Lys Glu Ala Tyr Ile Ala Met Gly Gln Arg
            420                 425                 430         
Met Phe Glu Asp Leu Phe Glu
        435                 


<210> 1234
<211> 328
<212> PRT
<213> Homo sapiens

<400> 1234
Met Ala Ala Gly Ile Val Ala Ser Arg Arg Leu Arg Asp Leu Leu Thr
 1               5                  10                  15      
Arg Arg Leu Thr Gly Ser Asn Tyr Pro Gly Leu Ser Ile Ser Leu Arg
            20                  25                  30          
Leu Thr Gly Ser Ser Ala Gln Glu Glu Ala Ser Gly Val Ala Leu Gly
        35                  40                  45              
Glu Ala Pro Asp His Ser Tyr Glu Ser Leu Arg Val Thr Ser Ala Gln
    50                  55                  60                  
Lys His Val Leu His Val Gln Leu Asn Arg Pro Asn Lys Arg Asn Ala
65                  70                  75                  80  
Met Asn Lys Val Phe Trp Arg Glu Met Val Glu Cys Phe Asn Lys Ile
                85                  90                  95      
Ser Arg Asp Ala Asp Cys Arg Ala Val Val Ile Ser Gly Ala Gly Lys
            100                 105                 110         
Met Phe Thr Ala Gly Ile Asp Leu Met Asp Met Ala Ser Asp Ile Leu
        115                 120                 125             
Gln Pro Lys Gly Asp Asp Val Ala Arg Ile Ser Trp Tyr Leu Arg Asp
    130                 135                 140                 
Ile Ile Thr Arg Tyr Gln Glu Thr Phe Asn Val Ile Glu Arg Cys Pro
145                 150                 155                 160 
Lys Pro Val Ile Ala Ala Val His Gly Gly Cys Ile Gly Gly Gly Val
                165                 170                 175     
Asp Leu Val Thr Ala Cys Asp Ile Arg Tyr Cys Ala Gln Asp Ala Phe
            180                 185                 190         
Phe Gln Val Lys Glu Val Asp Val Gly Leu Ala Ala Asp Val Gly Thr
        195                 200                 205             
Leu Gln Arg Leu Pro Lys Val Ile Gly Asn Gln Ser Leu Val Asn Glu
    210                 215                 220                 
Leu Ala Phe Thr Ala Arg Lys Met Met Ala Asp Glu Ala Leu Gly Ser
225                 230                 235                 240 
Gly Leu Val Ser Arg Val Phe Pro Asp Lys Glu Val Met Leu Asp Ala
                245                 250                 255     
Ala Leu Ala Leu Ala Ala Glu Ile Ser Ser Lys Ser Pro Val Ala Val
            260                 265                 270         
Gln Ser Thr Lys Val Asn Leu Leu Tyr Ser Arg Asp His Ser Val Ala
        275                 280                 285             
Glu Ser Leu Asn Tyr Val Ala Ser Trp Asn Met Ser Met Leu Gln Thr
    290                 295                 300                 
Gln Asp Leu Val Lys Ser Val Gln Ala Thr Thr Glu Asn Lys Glu Leu
305                 310                 315                 320 
Lys Thr Val Thr Phe Ser Lys Leu
                325             


<210> 1235
<211> 471
<212> PRT
<213> Homo sapiens

<400> 1235
Met Pro Asn Ser Glu Pro Ala Ser Leu Leu Glu Leu Phe Asn Ser Ile
 1               5                  10                  15      
Ala Thr Gln Gly Glu Leu Val Arg Ser Leu Lys Ala Gly Asn Ala Ser
            20                  25                  30          
Lys Asp Glu Ile Asp Ser Ala Val Lys Met Leu Val Ser Leu Lys Met
        35                  40                  45              
Ser Tyr Lys Ala Ala Ala Gly Glu Asp Tyr Lys Ala Asp Cys Pro Pro
    50                  55                  60                  
Gly Asn Pro Ala Pro Thr Ser Asn His Gly Pro Asp Ala Thr Glu Ala
65                  70                  75                  80  
Glu Glu Asp Phe Val Asp Pro Trp Thr Val Gln Thr Ser Ser Ala Lys
                85                  90                  95      
Gly Ile Asp Tyr Asp Lys Leu Ile Val Arg Phe Gly Ser Ser Lys Ile
            100                 105                 110         
Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala Thr Gly Gln Arg Pro
        115                 120                 125             
His His Phe Leu Arg Arg Gly Ile Phe Phe Ser His Arg Asp Met Asn
    130                 135                 140                 
Gln Val Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe Tyr Leu Tyr Thr
145                 150                 155                 160 
Gly Arg Gly Pro Ser Ser Glu Ala Met His Val Gly His Leu Ile Pro
                165                 170                 175     
Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe Asn Val Pro Leu Val
            180                 185                 190         
Ile Gln Met Thr Asp Asp Glu Lys Tyr Leu Trp Lys Asp Leu Thr Leu
        195                 200                 205             
Asp Gln Ala Tyr Ser Tyr Ala Val Glu Asn Ala Lys Asp Ile Ile Ala
    210                 215                 220                 
Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser Asp Leu Asp Tyr
225                 230                 235                 240 
Met Gly Met Ser Ser Gly Phe Tyr Lys Asn Val Val Lys Ile Gln Lys
                245                 250                 255     
His Val Thr Phe Asn Gln Val Lys Gly Ile Phe Gly Phe Thr Asp Ser
            260                 265                 270         
Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala Ile Gln Ala Ala Pro Ser
        275                 280                 285             
Phe Ser Asn Ser Phe Pro Gln Ile Phe Arg Asp Arg Thr Asp Ile Gln
    290                 295                 300                 
Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr Phe Arg Met Thr
305                 310                 315                 320 
Arg Asp Val Ala Pro Arg Ile Gly Tyr Pro Lys Pro Ala Leu Leu His
                325                 330                 335     
Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys Met Ser Ala
            340                 345                 350         
Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala Lys Gln Ile
        355                 360                 365             
Lys Thr Lys Val Asn Lys His Ala Phe Ser Gly Gly Arg Asp Thr Ile
    370                 375                 380                 
Glu Glu His Arg Gln Phe Gly Gly Asn Cys Asp Val Asp Val Ser Phe
385                 390                 395                 400 
Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp Asp Lys Leu Glu Gln Ile
                405                 410                 415     
Arg Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly Glu Leu Lys Lys
            420                 425                 430         
Ala Leu Ile Glu Val Leu Gln Pro Leu Ile Ala Glu His Gln Ala Arg
        435                 440                 445             
Arg Lys Glu Val Thr Asp Glu Ile Val Lys Glu Phe Met Thr Pro Arg
    450                 455                 460                 
Lys Leu Ser Phe Asp Phe Gln
465                 470     


<210> 1236
<211> 567
<212> PRT
<213> Homo sapiens

<400> 1236
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu
 1               5                  10                  15      
Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val
            20                  25                  30          
Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro
        35                  40                  45              
Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln
    50                  55                  60                  
Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro
65                  70                  75                  80  
Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr
                85                  90                  95      
Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile
            100                 105                 110         
Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys
        115                 120                 125             
Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn
    130                 135                 140                 
Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu
145                 150                 155                 160 
Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu
                165                 170                 175     
Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn
            180                 185                 190         
Arg Gln Gln Lys Leu Ser Ser Thr Trp Glu Thr Gly Lys Thr Arg Lys
        195                 200                 205             
Leu Met Glu Phe Ser Glu His Cys Ala Ile Ile Leu Glu Asp Asp Arg
    210                 215                 220                 
Ser Asp Ile Ser Ser Thr Cys Ala Asn Asn Ile Asn His Asn Thr Glu
225                 230                 235                 240 
Leu Leu Pro Ile Glu Leu Asp Thr Leu Val Gly Lys Gly Arg Phe Ala
                245                 250                 255     
Glu Val Tyr Lys Ala Lys Leu Lys Gln Asn Thr Ser Glu Gln Phe Glu
            260                 265                 270         
Thr Val Ala Val Lys Ile Phe Pro Tyr Glu Glu Tyr Ala Ser Trp Lys
        275                 280                 285             
Thr Glu Lys Asp Ile Phe Ser Asp Ile Asn Leu Lys His Glu Asn Ile
    290                 295                 300                 
Leu Gln Phe Leu Thr Ala Glu Glu Arg Lys Thr Glu Leu Gly Lys Gln
305                 310                 315                 320 
Tyr Trp Leu Ile Thr Ala Phe His Ala Lys Gly Asn Leu Gln Glu Tyr
                325                 330                 335     
Leu Thr Arg His Val Ile Ser Trp Glu Asp Leu Arg Lys Leu Gly Ser
            340                 345                 350         
Ser Leu Ala Arg Gly Ile Ala His Leu His Ser Asp His Thr Pro Cys
        355                 360                 365             
Gly Arg Pro Lys Met Pro Ile Val His Arg Asp Leu Lys Ser Ser Asn
    370                 375                 380                 
Ile Leu Val Lys Asn Asp Leu Thr Cys Cys Leu Cys Asp Phe Gly Leu
385                 390                 395                 400 
Ser Leu Arg Leu Asp Pro Thr Leu Ser Val Asp Asp Leu Ala Asn Ser
                405                 410                 415     
Gly Gln Val Gly Thr Ala Arg Tyr Met Ala Pro Glu Val Leu Glu Ser
            420                 425                 430         
Arg Met Asn Leu Glu Asn Val Glu Ser Phe Lys Gln Thr Asp Val Tyr
        435                 440                 445             
Ser Met Ala Leu Val Leu Trp Glu Met Thr Ser Arg Cys Asn Ala Val
    450                 455                 460                 
Gly Glu Val Lys Asp Tyr Glu Pro Pro Phe Gly Ser Lys Val Arg Glu
465                 470                 475                 480 
His Pro Cys Val Glu Ser Met Lys Asp Asn Val Leu Arg Asp Arg Gly
                485                 490                 495     
Arg Pro Glu Ile Pro Ser Phe Trp Leu Asn His Gln Gly Ile Gln Met
            500                 505                 510         
Val Cys Glu Thr Leu Thr Glu Cys Trp Asp His Asp Pro Glu Ala Arg
        515                 520                 525             
Leu Thr Ala Gln Cys Val Ala Glu Arg Phe Ser Glu Leu Glu His Leu
    530                 535                 540                 
Asp Arg Leu Ser Gly Arg Ser Cys Ser Glu Glu Lys Ile Pro Glu Asp
545                 550                 555                 560 
Gly Ser Leu Asn Thr Thr Lys
                565         


<210> 1237
<211> 548
<212> PRT
<213> Homo sapiens

<400> 1237
Met Gln Gly Leu Leu Arg Phe Glu Asp Gln Asp Ser Ala Arg Gly Asp
 1               5                  10                  15      
Gln Asn Ile Ala Met Phe Tyr Pro Thr Ser Thr Gln Met Val Tyr Arg
            20                  25                  30          
Arg Gly Leu Gln Ala Ile Pro Leu Ser Val Asp Leu Trp Ile His Tyr
        35                  40                  45              
Ile Asn Phe Leu Lys Glu Thr Leu Asp Pro Gly Asp Pro Glu Thr Asn
    50                  55                  60                  
Asn Thr Ile Arg Gly Thr Phe Glu His Ala Val Leu Ala Ala Gly Thr
65                  70                  75                  80  
Asp Phe Arg Ser Asp Arg Leu Trp Glu Met Tyr Ile Asn Trp Glu Asn
                85                  90                  95      
Glu Gln Gly Asn Leu Arg Glu Val Thr Ala Ile Tyr Asp Arg Ile Leu
            100                 105                 110         
Gly Ile Pro Thr Gln Leu Tyr Ser His His Phe Gln Arg Phe Lys Glu
        115                 120                 125             
His Val Gln Asn Asn Leu Pro Arg Asp Leu Leu Thr Gly Glu Gln Phe
    130                 135                 140                 
Ile Gln Leu Arg Arg Glu Leu Ala Ser Val Asn Gly His Ser Gly Asp
145                 150                 155                 160 
Asp Gly Pro Pro Gly Asp Asp Leu Pro Ser Gly Ile Glu Asp Ile Thr
                165                 170                 175     
Asp Pro Ala Lys Leu Ile Thr Glu Ile Glu Asn Met Arg His Arg Ile
            180                 185                 190         
Ile Glu Ile His Gln Glu Met Phe Asn Tyr Asn Glu His Glu Val Ser
        195                 200                 205             
Lys Arg Trp Thr Phe Glu Glu Gly Ile Lys Arg Pro Tyr Phe His Val
    210                 215                 220                 
Lys Pro Leu Glu Lys Ala Gln Leu Lys Asn Trp Lys Glu Tyr Leu Glu
225                 230                 235                 240 
Phe Glu Ile Glu Asn Gly Thr His Glu Arg Val Val Val Leu Phe Glu
                245                 250                 255     
Arg Cys Val Ile Ser Cys Ala Leu Tyr Glu Glu Phe Trp Ile Lys Tyr
            260                 265                 270         
Ala Lys Tyr Met Glu Asn His Ser Ile Glu Gly Val Arg His Val Phe
        275                 280                 285             
Ser Arg Ala Cys Thr Ile His Leu Pro Lys Lys Pro Met Val His Met
    290                 295                 300                 
Leu Trp Ala Ala Phe Glu Glu Gln Gln Gly Asn Ile Asn Glu Ala Arg
305                 310                 315                 320 
Asn Ile Leu Lys Thr Phe Glu Glu Cys Val Leu Gly Leu Ala Met Val
                325                 330                 335     
Arg Leu Arg Arg Val Ser Leu Glu Arg Arg His Gly Asn Leu Glu Glu
            340                 345                 350         
Ala Glu His Leu Leu Gln Asp Ala Ile Lys Asn Ala Lys Ser Asn Asn
        355                 360                 365             
Glu Ser Ser Phe Tyr Ala Val Lys Leu Ala Arg His Leu Phe Lys Ile
    370                 375                 380                 
Gln Lys Asn Leu Pro Lys Ser Arg Lys Val Leu Leu Glu Ala Ile Glu
385                 390                 395                 400 
Arg Asp Lys Glu Asn Thr Lys Leu Tyr Leu Asn Leu Leu Glu Met Glu
                405                 410                 415     
Tyr Ser Gly Asp Leu Lys Gln Asn Glu Glu Asn Ile Leu Asn Cys Phe
            420                 425                 430         
Asp Lys Ala Val His Gly Ser Leu Pro Ile Lys Met Arg Ile Thr Phe
        435                 440                 445             
Ser Gln Arg Lys Val Glu Phe Leu Glu Asp Phe Gly Ser Asp Val Asn
    450                 455                 460                 
Lys Leu Leu Asn Ala Tyr Asp Glu His Gln Thr Leu Leu Lys Glu Gln
465                 470                 475                 480 
Asp Ser Leu Lys Arg Lys Ala Glu Asn Gly Ser Glu Glu Pro Glu Glu
                485                 490                 495     
Lys Lys Ala His Thr Glu Asp Thr Thr Ser Ser Ser Thr Gln Met Ile
            500                 505                 510         
Asp Gly Asp Leu Gln Ala Asn Gln Ala Val Tyr Asn Tyr Ser Ala Trp
        515                 520                 525             
Tyr Gln Tyr Asn Tyr Gln Asn Pro Trp Asn Tyr Gly Gln Tyr Tyr Pro
    530                 535                 540                 
Pro Pro Pro Thr
545             


<210> 1238
<211> 468
<212> PRT
<213> Homo sapiens

<400> 1238
Met Ala Ala Arg Leu Val Ser Arg Cys Gly Ala Val Arg Ala Ala Pro
 1               5                  10                  15      
His Ser Gly Pro Leu Val Ser Trp Arg Arg Trp Ser Gly Ala Ser Thr
            20                  25                  30          
Asp Thr Val Tyr Asp Val Val Val Ser Gly Gly Gly Leu Val Gly Ala
        35                  40                  45              
Ala Met Ala Cys Ala Leu Gly Tyr Asp Ile His Phe His Asp Lys Lys
    50                  55                  60                  
Ile Leu Leu Leu Glu Ala Gly Pro Lys Lys Val Leu Glu Lys Leu Ser
65                  70                  75                  80  
Glu Thr Tyr Ser Asn Arg Val Ser Ser Ile Ser Pro Gly Ser Ala Thr
                85                  90                  95      
Leu Leu Ser Ser Phe Gly Ala Trp Asp His Ile Cys Asn Met Arg Tyr
            100                 105                 110         
Arg Ala Phe Arg Arg Met Gln Val Trp Asp Ala Cys Ser Glu Ala Leu
        115                 120                 125             
Ile Met Phe Asp Lys Asp Asn Leu Asp Asp Met Gly Tyr Ile Val Glu
    130                 135                 140                 
Asn Asp Val Ile Met His Ala Leu Thr Lys Gln Leu Glu Ala Val Ser
145                 150                 155                 160 
Asp Arg Val Thr Val Leu Tyr Arg Ser Lys Ala Ile Arg Tyr Thr Trp
                165                 170                 175     
Pro Cys Pro Phe Pro Met Ala Asp Ser Ser Pro Trp Val His Ile Thr
            180                 185                 190         
Leu Gly Asp Gly Ser Thr Phe Gln Thr Lys Leu Leu Ile Gly Ala Asp
        195                 200                 205             
Gly His Asn Ser Gly Val Arg Gln Ala Val Gly Ile Gln Asn Val Ser
    210                 215                 220                 
Trp Asn Tyr Asp Gln Ser Ala Val Val Ala Thr Leu His Leu Ser Glu
225                 230                 235                 240 
Ala Thr Glu Asn Asn Val Ala Trp Gln Arg Phe Leu Pro Ser Gly Pro
                245                 250                 255     
Ile Ala Leu Leu Pro Leu Ser Asp Thr Leu Ser Ser Leu Val Trp Ser
            260                 265                 270         
Thr Ser His Glu His Ala Ala Glu Leu Val Ser Met Asp Glu Glu Lys
        275                 280                 285             
Phe Val Asp Ala Val Asn Ser Ala Phe Trp Ser Asp Ala Asp His Thr
    290                 295                 300                 
Asp Phe Ile Asp Thr Ala Gly Ala Met Leu Gln Tyr Ala Val Ser Leu
305                 310                 315                 320 
Leu Lys Pro Thr Lys Val Ser Ala Arg Gln Leu Pro Pro Ser Val Ala
                325                 330                 335     
Arg Val Asp Ala Lys Ser Arg Val Leu Phe Pro Leu Gly Leu Gly His
            340                 345                 350         
Ala Ala Glu Tyr Val Arg Pro Arg Val Ala Leu Ile Gly Asp Ala Ala
        355                 360                 365             
His Arg Val His Pro Leu Ala Gly Gln Gly Val Asn Met Gly Phe Gly
    370                 375                 380                 
Asp Ile Ser Ser Leu Ala His His Leu Ser Thr Ala Ala Phe Asn Gly
385                 390                 395                 400 
Lys Asp Leu Gly Ser Val Ser His Leu Thr Gly Tyr Glu Thr Glu Arg
                405                 410                 415     
Gln Arg His Asn Thr Ala Leu Leu Ala Ala Thr Asp Leu Leu Lys Arg
            420                 425                 430         
Leu Tyr Ser Thr Ser Ala Ser Pro Leu Val Leu Leu Arg Thr Trp Gly
        435                 440                 445             
Leu Gln Ala Thr Asn Ala Val Ser Pro Leu Lys Glu Gln Ile Met Ala
    450                 455                 460                 
Phe Ala Ser Lys
465             


<210> 1239
<211> 145
<212> PRT
<213> Homo sapiens

<400> 1239
Met Asn Gly Arg Val Asp Tyr Leu Val Thr Glu Glu Glu Ile Asn Leu
 1               5                  10                  15      
Thr Arg Gly Pro Ser Gly Leu Gly Phe Asn Ile Val Gly Gly Thr Asp
            20                  25                  30          
Gln Gln Tyr Val Ser Asn Asp Ser Gly Ile Tyr Val Ser Arg Ile Lys
        35                  40                  45              
Glu Asn Gly Ala Ala Ala Leu Asp Gly Arg Leu Gln Glu Gly Asp Lys
    50                  55                  60                  
Ile Leu Ser Val Asn Gly Gln Asp Leu Lys Asn Leu Leu His Gln Asp
65                  70                  75                  80  
Ala Val Asp Leu Phe Arg Asn Ala Gly Tyr Ala Val Ser Leu Arg Val
                85                  90                  95      
Gln His Arg Leu Gln Val Gln Asn Gly Pro Ile Gly His Arg Gly Glu
            100                 105                 110         
Gly Asp Pro Ser Gly Ile Pro Ile Phe Met Val Leu Val Pro Val Phe
        115                 120                 125             
Ala Leu Thr Met Val Ala Ala Trp Ala Phe Met Arg Tyr Arg Gln Gln
    130                 135                 140                 
Leu
145 


<210> 1240
<211> 879
<212> PRT
<213> Homo sapiens

<400> 1240
Met Arg Leu His Leu Leu Leu Leu Leu Ala Leu Cys Gly Ala Gly Thr
 1               5                  10                  15      
Thr Ala Ala Glu Leu Ser Tyr Ser Leu Arg Gly Asn Trp Ser Ile Cys
            20                  25                  30          
Asn Gly Asn Gly Ser Leu Glu Leu Pro Gly Ala Val Pro Gly Cys Val
        35                  40                  45              
His Ser Ala Leu Phe Gln Gln Gly Leu Ile Gln Asp Ser Tyr Tyr Arg
    50                  55                  60                  
Phe Asn Asp Leu Asn Tyr Arg Trp Val Ser Leu Asp Asn Trp Thr Tyr
65                  70                  75                  80  
Ser Lys Glu Phe Lys Ile Pro Phe Glu Ile Ser Lys Trp Gln Lys Val
                85                  90                  95      
Asn Leu Ile Leu Glu Gly Val Asp Thr Val Ser Lys Ile Leu Phe Asn
            100                 105                 110         
Glu Val Thr Ile Gly Glu Thr Asp Asn Met Phe Asn Arg Tyr Ser Phe
        115                 120                 125             
Asp Ile Thr Asn Val Val Arg Asp Val Asn Ser Ile Glu Leu Arg Phe
    130                 135                 140                 
Gln Ser Ala Val Leu Tyr Ala Ala Gln Gln Ser Lys Ala His Thr Arg
145                 150                 155                 160 
Tyr Gln Val Pro Pro Asp Cys Pro Pro Leu Val Gln Lys Gly Glu Cys
                165                 170                 175     
His Val Asn Phe Val Arg Lys Glu Gln Cys Ser Phe Ser Trp Asp Trp
            180                 185                 190         
Gly Pro Ser Phe Pro Thr Gln Gly Ile Trp Lys Asp Val Arg Ile Glu
        195                 200                 205             
Ala Tyr Asn Ile Cys His Leu Asn Tyr Phe Thr Phe Ser Pro Ile Tyr
    210                 215                 220                 
Asp Lys Ser Ala Gln Glu Trp Asn Leu Glu Ile Glu Ser Thr Phe Asp
225                 230                 235                 240 
Val Val Ser Ser Lys Pro Val Gly Gly Gln Val Ile Val Ala Ile Pro
                245                 250                 255     
Lys Leu Gln Thr Gln Gln Thr Tyr Ser Ile Glu Leu Gln Pro Gly Lys
            260                 265                 270         
Arg Ile Val Glu Leu Phe Val Asn Ile Ser Lys Asn Ile Thr Val Glu
        275                 280                 285             
Thr Trp Trp Pro His Gly His Gly Asn Gln Thr Gly Tyr Asn Met Thr
    290                 295                 300                 
Val Leu Phe Glu Leu Asp Gly Gly Leu Asn Ile Glu Lys Ser Ala Lys
305                 310                 315                 320 
Val Tyr Phe Arg Thr Val Glu Leu Ile Glu Glu Pro Ile Lys Gly Ser
                325                 330                 335     
Pro Gly Leu Ser Phe Tyr Phe Lys Ile Asn Gly Phe Pro Ile Phe Leu
            340                 345                 350         
Lys Gly Ser Asn Trp Ile Pro Ala Asp Ser Phe Gln Asp Arg Val Thr
        355                 360                 365             
Ser Glu Leu Leu Arg Leu Leu Leu Gln Ser Val Val Asp Ala Asn Met
    370                 375                 380                 
Asn Thr Leu Arg Val Trp Gly Gly Gly Ile Tyr Glu Gln Asp Glu Phe
385                 390                 395                 400 
Tyr Glu Leu Cys Asp Glu Leu Gly Ile Met Val Trp Gln Asp Phe Met
                405                 410                 415     
Phe Ala Cys Ala Leu Tyr Pro Thr Asp Gln Gly Phe Leu Asp Ser Val
            420                 425                 430         
Thr Ala Glu Val Ala Tyr Gln Ile Lys Arg Leu Lys Ser His Pro Ser
        435                 440                 445             
Ile Ile Ile Trp Ser Gly Asn Asn Glu Asn Glu Glu Ala Leu Met Met
    450                 455                 460                 
Asn Trp Tyr His Ile Ser Phe Thr Asp Arg Pro Ile Tyr Ile Lys Asp
465                 470                 475                 480 
Tyr Val Thr Leu Tyr Val Lys Asn Ile Arg Glu Leu Val Leu Ala Gly
                485                 490                 495     
Asp Lys Ser Arg Pro Phe Ile Thr Ser Ser Pro Thr Asn Gly Ala Glu
            500                 505                 510         
Thr Val Ala Glu Ala Trp Val Ser Gln Asn Pro Asn Ser Asn Tyr Phe
        515                 520                 525             
Gly Asp Val His Phe Tyr Asp Tyr Ile Ser Asp Cys Trp Asn Trp Lys
    530                 535                 540                 
Val Phe Pro Lys Ala Arg Phe Ala Ser Glu Tyr Gly Tyr Gln Ser Trp
545                 550                 555                 560 
Pro Ser Phe Ser Thr Leu Glu Lys Val Ser Ser Thr Glu Asp Trp Ser
                565                 570                 575     
Phe Asn Ser Lys Phe Ser Leu His Arg Gln His His Glu Gly Gly Asn
            580                 585                 590         
Lys Gln Met Leu Tyr Gln Ala Gly Leu His Phe Lys Leu Pro Gln Ser
        595                 600                 605             
Thr Asp Pro Leu Arg Thr Phe Lys Asp Thr Ile Tyr Leu Thr Gln Val
    610                 615                 620                 
Met Gln Ala Gln Cys Val Lys Thr Glu Thr Glu Phe Tyr Arg Arg Ser
625                 630                 635                 640 
Arg Ser Glu Ile Val Asp Gln Gln Gly His Thr Met Gly Ala Leu Tyr
                645                 650                 655     
Trp Gln Leu Asn Asp Ile Trp Gln Ala Pro Ser Trp Ala Ser Leu Glu
            660                 665                 670         
Tyr Gly Gly Lys Trp Lys Met Leu His Tyr Phe Ala Gln Asn Phe Phe
        675                 680                 685             
Ala Pro Leu Leu Pro Val Gly Phe Glu Asn Glu Asn Thr Phe Tyr Ile
    690                 695                 700                 
Tyr Gly Val Ser Asp Leu His Ser Asp Tyr Ser Met Thr Leu Ser Val
705                 710                 715                 720 
Arg Val His Thr Trp Ser Ser Leu Glu Pro Val Cys Ser Arg Val Thr
                725                 730                 735     
Glu Arg Phe Val Met Lys Gly Gly Glu Ala Val Cys Leu Tyr Glu Glu
            740                 745                 750         
Pro Val Ser Glu Leu Leu Arg Arg Cys Gly Asn Cys Thr Arg Glu Ser
        755                 760                 765             
Cys Val Val Ser Phe Tyr Leu Ser Ala Asp His Glu Leu Leu Ser Pro
    770                 775                 780                 
Thr Asn Tyr His Phe Leu Ser Ser Pro Lys Glu Ala Val Gly Leu Cys
785                 790                 795                 800 
Lys Ala Gln Ile Thr Ala Ile Ile Ser Gln Gln Gly Asp Ile Phe Val
                805                 810                 815     
Phe Asp Leu Glu Thr Ser Ala Val Ala Pro Phe Val Trp Leu Asp Val
            820                 825                 830         
Gly Ser Ile Pro Gly Arg Phe Ser Asp Asn Gly Phe Leu Met Thr Glu
        835                 840                 845             
Lys Thr Arg Thr Ile Leu Phe Tyr Pro Trp Glu Pro Thr Ser Lys Asn
    850                 855                 860                 
Glu Leu Glu Gln Ser Phe His Val Thr Ser Leu Thr Asp Ile Tyr
865                 870                 875                 


<210> 1241
<211> 204
<212> PRT
<213> Homo sapiens

<400> 1241
Met Ala Ala Ala Gly Trp Arg Asp Gly Ser Gly Gln Glu Lys Tyr Arg
 1               5                  10                  15      
Leu Val Val Val Gly Gly Gly Gly Val Gly Lys Ser Ala Leu Thr Ile
            20                  25                  30          
Gln Phe Ile Gln Ser Tyr Phe Val Thr Asp Tyr Asp Pro Thr Ile Glu
        35                  40                  45              
Asp Ser Tyr Thr Lys Gln Cys Val Ile Asp Asp Arg Ala Ala Arg Leu
    50                  55                  60                  
Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Phe Gly Ala Met Arg Glu
65                  70                  75                  80  
Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Leu Val Phe Ser Val Thr
                85                  90                  95      
Asp Arg Gly Ser Phe Glu Glu Ile Tyr Lys Phe Gln Arg Gln Ile Leu
            100                 105                 110         
Arg Val Lys Asp Arg Asp Glu Phe Pro Met Ile Leu Ile Gly Asn Lys
        115                 120                 125             
Ala Asp Leu Asp His Gln Arg Gln Val Thr Gln Glu Glu Gly Gln Gln
    130                 135                 140                 
Leu Ala Arg Gln Leu Lys Val Thr Tyr Met Glu Ala Ser Ala Lys Ile
145                 150                 155                 160 
Arg Met Asn Val Asp Gln Ala Phe His Glu Leu Val Arg Val Ile Arg
                165                 170                 175     
Lys Phe Gln Glu Gln Glu Cys Pro Pro Ser Pro Glu Pro Thr Arg Lys
            180                 185                 190         
Glu Lys Asp Lys Lys Gly Cys His Cys Val Ile Phe
        195                 200                 


<210> 1242
<211> 517
<212> PRT
<213> Homo sapiens

<400> 1242
Met Leu Arg Ala Ala Ala Arg Phe Gly Pro Arg Leu Gly Arg Arg Leu
 1               5                  10                  15      
Leu Ser Ala Ala Ala Thr Gln Ala Val Pro Ala Pro Asn Gln Gln Pro
            20                  25                  30          
Glu Val Phe Cys Asn Gln Ile Phe Ile Asn Asn Glu Trp His Asp Ala
        35                  40                  45              
Val Ser Arg Lys Thr Phe Pro Thr Val Asn Pro Ser Thr Gly Glu Val
    50                  55                  60                  
Ile Cys Gln Val Ala Glu Gly Asp Lys Glu Asp Val Asp Lys Ala Val
65                  70                  75                  80  
Lys Ala Ala Arg Ala Ala Phe Gln Leu Gly Ser Pro Trp Arg Arg Met
                85                  90                  95      
Asp Ala Ser His Arg Gly Arg Leu Leu Asn Arg Leu Ala Asp Leu Ile
            100                 105                 110         
Glu Arg Asp Arg Thr Tyr Leu Ala Ala Leu Glu Thr Leu Asp Asn Gly
        115                 120                 125             
Lys Pro Tyr Val Ile Ser Tyr Leu Val Asp Leu Asp Met Val Leu Lys
    130                 135                 140                 
Cys Leu Arg Tyr Tyr Ala Gly Trp Ala Asp Lys Tyr His Gly Lys Thr
145                 150                 155                 160 
Ile Pro Ile Asp Gly Asp Phe Phe Ser Tyr Thr Arg His Glu Pro Val
                165                 170                 175     
Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Leu Met Gln
            180                 185                 190         
Ala Trp Lys Leu Gly Pro Ala Leu Ala Thr Gly Asn Val Val Val Met
        195                 200                 205             
Lys Val Ala Glu Gln Thr Pro Leu Thr Ala Leu Tyr Val Ala Asn Leu
    210                 215                 220                 
Ile Lys Glu Ala Gly Phe Pro Pro Gly Val Val Asn Ile Val Pro Gly
225                 230                 235                 240 
Phe Gly Pro Thr Ala Gly Ala Ala Ile Ala Ser His Glu Asp Val Asp
                245                 250                 255     
Lys Val Ala Phe Thr Gly Ser Thr Glu Ile Gly Arg Val Ile Gln Val
            260                 265                 270         
Ala Ala Gly Ser Ser Asn Leu Lys Arg Val Thr Leu Glu Leu Gly Gly
        275                 280                 285             
Lys Ser Pro Asn Ile Ile Met Ser Asp Ala Asp Met Asp Trp Ala Val
    290                 295                 300                 
Glu Gln Ala His Phe Ala Leu Phe Phe Asn Gln Gly Gln Cys Cys Cys
305                 310                 315                 320 
Ala Gly Ser Arg Thr Phe Val Gln Glu Asp Ile Tyr Asp Glu Phe Val
                325                 330                 335     
Glu Arg Ser Val Ala Arg Ala Lys Ser Arg Val Val Gly Asn Pro Phe
            340                 345                 350         
Asp Ser Lys Thr Glu Gln Gly Pro Gln Val Asp Glu Thr Gln Phe Lys
        355                 360                 365             
Lys Ile Leu Gly Tyr Ile Asn Thr Gly Lys Gln Glu Gly Ala Lys Leu
    370                 375                 380                 
Leu Cys Gly Gly Gly Ile Ala Ala Asp Arg Gly Tyr Phe Ile Gln Pro
385                 390                 395                 400 
Thr Val Phe Gly Asp Val Gln Asp Gly Met Thr Ile Ala Lys Glu Glu
                405                 410                 415     
Ile Phe Gly Pro Val Met Gln Ile Leu Lys Phe Lys Thr Ile Glu Glu
            420                 425                 430         
Val Val Gly Arg Ala Asn Asn Ser Thr Tyr Gly Leu Ala Ala Ala Val
        435                 440                 445             
Phe Thr Lys Asp Leu Asp Lys Ala Asn Tyr Leu Ser Gln Ala Leu Gln
    450                 455                 460                 
Ala Gly Thr Val Trp Val Asn Cys Tyr Asp Val Phe Gly Ala Gln Ser
465                 470                 475                 480 
Pro Phe Gly Gly Tyr Lys Met Ser Gly Ser Gly Arg Glu Leu Gly Glu
                485                 490                 495     
Tyr Gly Leu Gln Ala Tyr Thr Glu Val Lys Thr Val Thr Val Lys Val
            500                 505                 510         
Pro Gln Lys Asn Ser
        515         


<210> 1243
<211> 924
<212> PRT
<213> Homo sapiens

<400> 1243
Met Glu Ile Lys Glu Glu Gly Ala Ser Glu Glu Gly Gln His Phe Leu
 1               5                  10                  15      
Pro Thr Ala Gln Ala Asn Asp Pro Gly Asp Cys Gln Phe Thr Ser Ile
            20                  25                  30          
Gln Lys Thr Pro Asn Glu Pro Gln Leu Glu Phe Ile Leu Ala Cys Lys
        35                  40                  45              
Asp Leu Val Ala Pro Val Arg Asp Arg Lys Leu Asn Thr Leu Val Gln
    50                  55                  60                  
Ile Ser Val Ile His Pro Val Glu Gln Ser Leu Thr Arg Tyr Ser Ser
65                  70                  75                  80  
Thr Glu Ile Val Glu Gly Thr Arg Asp Pro Leu Phe Leu Thr Gly Val
                85                  90                  95      
Thr Phe Pro Ser Glu Tyr Pro Ile Tyr Glu Glu Thr Lys Ile Lys Leu
            100                 105                 110         
Thr Val Tyr Asp Val Lys Asp Lys Ser His Asp Thr Val Arg Thr Ser
        115                 120                 125             
Val Leu Pro Glu His Lys Asp Pro Pro Pro Glu Val Gly Arg Ser Phe
    130                 135                 140                 
Leu Gly Tyr Ala Ser Phe Lys Val Gly Glu Leu Leu Lys Ser Lys Glu
145                 150                 155                 160 
Gln Leu Leu Val Leu Ser Leu Arg Thr Ser Asp Gly Gly Lys Val Val
                165                 170                 175     
Gly Thr Ile Glu Val Ser Val Val Lys Met Gly Glu Ile Glu Asp Gly
            180                 185                 190         
Glu Ala Asp His Ile Thr Thr Asp Val Gln Gly Gln Lys Cys Ala Leu
        195                 200                 205             
Val Cys Glu Cys Thr Ala Pro Glu Ser Val Ser Gly Lys Asp Asn Leu
    210                 215                 220                 
Pro Phe Leu Asn Ser Val Leu Lys Asn Pro Val Cys Lys Leu Tyr Arg
225                 230                 235                 240 
Phe Pro Thr Ser Asp Asn Lys Trp Met Arg Ile Arg Glu Gln Met Ser
                245                 250                 255     
Glu Ser Ile Leu Ser Phe His Ile Pro Lys Glu Leu Ile Ser Leu His
            260                 265                 270         
Ile Lys Glu Asp Leu Cys Arg Asn Gln Glu Ile Lys Glu Leu Gly Glu
        275                 280                 285             
Leu Ser Pro His Trp Asp Asn Leu Arg Lys Asn Val Leu Thr His Cys
    290                 295                 300                 
Asp Gln Met Val Asn Met Tyr Gln Asp Ile Leu Thr Glu Leu Ser Lys
305                 310                 315                 320 
Glu Thr Gly Ser Ser Phe Lys Ser Ser Ser Ser Lys Gly Glu Lys Thr
                325                 330                 335     
Leu Glu Phe Val Pro Ile Asn Leu His Leu Gln Arg Met Gln Val His
            340                 345                 350         
Ser Pro His Leu Lys Asp Ala Leu Tyr Asp Val Ile Thr Val Gly Ala
        355                 360                 365             
Pro Ala Ala His Phe Gln Gly Phe Lys Asn Gly Gly Leu Arg Lys Leu
    370                 375                 380                 
Leu His Arg Phe Glu Thr Glu Arg Arg Asn Thr Gly Tyr Gln Phe Ile
385                 390                 395                 400 
Tyr Tyr Ser Pro Glu Asn Thr Ala Lys Ala Lys Glu Val Leu Ser Asn
                405                 410                 415     
Ile Asn Gln Leu Gln Pro Leu Ile Ala Thr His Ala Asp Leu Leu Leu
            420                 425                 430         
Asn Ser Ala Ser Gln His Ser Pro Asp Ser Leu Lys Asn Ser Leu Lys
        435                 440                 445             
Met Leu Ser Glu Lys Thr Glu Leu Phe Val His Ala Phe Lys Asp Gln
    450                 455                 460                 
Leu Val Arg Ser Ala Leu Leu Ala Leu Tyr Thr Ala Arg Pro Gly Gly
465                 470                 475                 480 
Ile Leu Lys Lys Pro Pro Ser Pro Lys Ser Ser Thr Glu Glu Ser Ser
                485                 490                 495     
Pro Gln Asp Gln Pro Pro Val Met Arg Gly Gln Asp Ser Ile Pro His
            500                 505                 510         
His Ser Asp Tyr Asp Glu Glu Glu Trp Asp Arg Val Trp Ala Asn Val
        515                 520                 525             
Gly Lys Ser Leu Asn Cys Ile Ile Ala Met Val Asp Lys Leu Ile Glu
    530                 535                 540                 
Arg Asp Gly Gly Ser Glu Gly Ser Gly Gly Asn Asn Asp Gly Glu Lys
545                 550                 555                 560 
Glu Pro Ser Leu Thr Asp Ala Ile Pro Ser His Pro Arg Glu Asp Trp
                565                 570                 575     
Tyr Glu Gln Leu Tyr Pro Leu Ile Leu Thr Leu Lys Asp Cys Met Gly
            580                 585                 590         
Glu Val Val Asn Arg Ala Lys Gln Ser Leu Thr Phe Val Leu Leu Gln
        595                 600                 605             
Glu Leu Ala Tyr Ser Leu Pro Gln Cys Leu Met Leu Thr Leu Arg Arg
    610                 615                 620                 
Asp Ile Val Phe Ser Gln Ala Leu Ala Gly Leu Val Cys Gly Phe Ile
625                 630                 635                 640 
Ile Lys Leu Gln Thr Ser Leu Tyr Asp Pro Gly Phe Leu Gln Gln Leu
                645                 650                 655     
His Thr Val Gly Leu Ile Val Gln Tyr Glu Gly Leu Leu Ser Thr Tyr
            660                 665                 670         
Ser Asp Glu Ile Gly Met Leu Glu Asp Met Ala Val Gly Ile Ser Asp
        675                 680                 685             
Leu Lys Lys Val Ala Phe Lys Ile Ile Glu Ala Lys Ser Asn Asp Val
    690                 695                 700                 
Leu Pro Val Ile Thr Gly Arg Arg Glu His Tyr Val Val Glu Val Lys
705                 710                 715                 720 
Leu Pro Ala Arg Met Phe Glu Ser Leu Pro Leu Gln Ile Lys Glu Gly
                725                 730                 735     
Gln Leu Leu His Val Tyr Pro Val Leu Phe Asn Val Gly Ile Asn Glu
            740                 745                 750         
Gln Gln Thr Leu Ala Glu Arg Phe Gly Asp Val Ser Leu Gln Glu Ser
        755                 760                 765             
Ile Asn Gln Glu Asn Phe Glu Leu Leu Gln Glu Tyr Tyr Lys Ile Phe
    770                 775                 780                 
Met Glu Lys Met Pro Pro Asp Tyr Ile Ser His Phe Gln Glu Gln Asn
785                 790                 795                 800 
Asp Leu Lys Ala Leu Leu Glu Asn Leu Leu Gln Asn Ile Gln Ser Lys
                805                 810                 815     
Lys Arg Lys Asn Val Glu Ile Met Trp Leu Ala Ala Thr Ile Cys Arg
            820                 825                 830         
Lys Leu Asn Gly Ile Arg Phe Thr Cys Cys Lys Ser Ala Lys Asp Arg
        835                 840                 845             
Thr Ser Met Ser Val Thr Leu Glu Gln Cys Ser Ile Leu Arg Asp Glu
    850                 855                 860                 
His Gln Leu His Lys Asp Phe Phe Ile Arg Ala Leu Asp Cys Met Arg
865                 870                 875                 880 
Arg Glu Gly Cys Arg Ile Glu Asn Val Leu Lys Asn Ile Lys Cys Arg
                885                 890                 895     
Lys Tyr Ala Phe Asn Met Leu Gln Leu Met Ala Phe Pro Lys Tyr Tyr
            900                 905                 910         
Arg Pro Pro Glu Gly Thr Tyr Gly Lys Ala Asp Thr
        915                 920                 


<210> 1244
<211> 462
<212> PRT
<213> Homo sapiens

<400> 1244
Met Ala Ala Thr Val Asn Leu Glu Leu Asp Pro Ile Phe Leu Lys Ala
 1               5                  10                  15      
Leu Gly Phe Leu His Ser Lys Ser Lys Asp Ser Ala Glu Lys Leu Lys
            20                  25                  30          
Ala Leu Leu Asp Glu Ser Leu Ala Arg Gly Ile Asp Ser Ser Tyr Arg
        35                  40                  45              
Pro Ser Gln Lys Asp Val Glu Pro Pro Lys Ile Ser Ser Thr Lys Asn
    50                  55                  60                  
Ile Ser Ile Lys Gln Glu Pro Lys Ile Ser Ser Ser Leu Pro Ser Gly
65                  70                  75                  80  
Asn Asn Asn Gly Lys Val Leu Thr Thr Glu Lys Val Lys Lys Glu Ala
                85                  90                  95      
Glu Lys Arg Pro Ala Asp Lys Met Lys Ser Asp Ile Thr Glu Gly Val
            100                 105                 110         
Asp Ile Pro Lys Lys Pro Arg Leu Glu Lys Pro Glu Thr Gln Ser Ser
        115                 120                 125             
Pro Ile Thr Val Gln Ser Ser Lys Asp Leu Pro Met Ala Asp Leu Ser
    130                 135                 140                 
Ser Phe Glu Glu Thr Ser Ala Asp Asp Phe Ala Met Glu Met Gly Leu
145                 150                 155                 160 
Ala Cys Val Val Cys Arg Gln Met Met Val Ala Ser Gly Asn Gln Leu
                165                 170                 175     
Val Glu Cys Gln Glu Cys His Asn Leu Tyr His Arg Asp Cys His Lys
            180                 185                 190         
Pro Gln Val Thr Asp Lys Glu Ala Asn Asp Pro Arg Leu Val Trp Tyr
        195                 200                 205             
Cys Ala Arg Cys Thr Arg Gln Met Lys Arg Met Ala Gln Lys Thr Gln
    210                 215                 220                 
Lys Pro Pro Gln Lys Pro Ala Pro Ala Val Val Ser Val Thr Pro Ala
225                 230                 235                 240 
Val Lys Asp Pro Leu Val Lys Lys Pro Glu Thr Lys Leu Lys Gln Glu
                245                 250                 255     
Thr Thr Phe Leu Ala Phe Lys Arg Thr Glu Val Lys Thr Ser Thr Val
            260                 265                 270         
Ile Ser Gly Asn Ser Ser Ser Ala Ser Val Ser Ser Ser Val Thr Ser
        275                 280                 285             
Gly Leu Thr Gly Trp Ala Ala Phe Ala Ala Lys Thr Ser Ser Ala Gly
    290                 295                 300                 
Pro Ser Thr Ala Lys Leu Ser Ser Thr Thr Gln Asn Asn Thr Gly Lys
305                 310                 315                 320 
Pro Ala Thr Ser Ser Ala Asn Gln Lys Pro Val Gly Leu Thr Gly Leu
                325                 330                 335     
Ala Thr Ser Ser Lys Gly Gly Ile Gly Ser Lys Ile Gly Ser Asn Asn
            340                 345                 350         
Ser Thr Thr Pro Thr Val Pro Leu Lys Pro Pro Pro Pro Leu Thr Leu
        355                 360                 365             
Gly Lys Thr Gly Leu Ser Arg Ser Val Ser Cys Asp Asn Val Ser Lys
    370                 375                 380                 
Val Gly Leu Pro Ser Pro Ser Ser Leu Val Pro Gly Ser Ser Ser Gln
385                 390                 395                 400 
Leu Ser Gly Asn Gly Asn Ser Gly Thr Ser Gly Pro Ser Gly Ser Thr
                405                 410                 415     
Thr Ser Lys Thr Thr Ser Glu Ser Ser Ser Ser Pro Ser Ala Ser Leu
            420                 425                 430         
Lys Gly Pro Thr Ser Gln Glu Ser Gln Leu Asn Ala Met Lys Arg Leu
        435                 440                 445             
Gln Met Val Lys Lys Lys Ala Ala Gln Lys Lys Leu Lys Lys
    450                 455                 460         


<210> 1245
<211> 201
<212> PRT
<213> Homo sapiens

<400> 1245
Met Ala Asn Lys Gly Pro Ser Tyr Gly Met Ser Arg Glu Val Gln Ser
 1               5                  10                  15      
Lys Ile Glu Lys Lys Tyr Asp Glu Glu Leu Glu Glu Arg Leu Val Glu
            20                  25                  30          
Trp Ile Ile Val Gln Cys Gly Pro Asp Val Gly Arg Pro Asp Arg Gly
        35                  40                  45              
Arg Leu Gly Phe Gln Val Trp Leu Lys Asn Gly Val Ile Leu Ser Lys
    50                  55                  60                  
Leu Val Asn Ser Leu Tyr Pro Asp Gly Ser Lys Pro Val Lys Val Pro
65                  70                  75                  80  
Glu Asn Pro Pro Ser Met Val Phe Lys Gln Met Glu Gln Val Ala Gln
                85                  90                  95      
Phe Leu Lys Ala Ala Glu Asp Tyr Gly Val Ile Lys Thr Asp Met Phe
            100                 105                 110         
Gln Thr Val Asp Leu Phe Glu Gly Lys Asp Met Ala Ala Val Gln Arg
        115                 120                 125             
Thr Leu Met Ala Leu Gly Ser Leu Ala Val Thr Lys Asn Asp Gly His
    130                 135                 140                 
Tyr Arg Gly Asp Pro Asn Trp Phe Met Lys Lys Ala Gln Glu His Lys
145                 150                 155                 160 
Arg Glu Phe Thr Glu Ser Gln Leu Gln Glu Gly Lys His Val Ile Gly
                165                 170                 175     
Leu Gln Met Gly Ser Asn Arg Gly Ala Ser Gln Ala Gly Met Thr Gly
            180                 185                 190         
Tyr Gly Arg Pro Arg Gln Ile Ile Ser
        195                 200     


<210> 1246
<211> 392
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 49, 90, 93
<223> Xaa = Any Amino Acid

<400> 1246
Met Glu Lys Leu Leu Glu Thr Ile Asp Gln Leu Gln Leu Glu Phe Ala
 1               5                  10                  15      
Arg Pro Arg Ala Leu Gln Gln Leu Ala Gly Trp Cys Arg Gly Gly Pro
            20                  25                  30          
Ala Gly Arg Val Ala Gly Thr Leu Cys Gly Gly Asp Pro Glu Pro Ala
        35                  40                  45              
Xaa Ser Ala Arg Ser Val Gln Gly Asn Glu Leu Pro Glu Ala Gly Arg
    50                  55                  60                  
Glu Arg Gly Ala Phe Met Gly Ile Gln Gly Glu Ile Gln Lys Phe Cys
65                  70                  75                  80  
Gln Thr Tyr Gly Leu Arg Pro Cys Ser Xaa Asn Pro Xaa Ile Thr Leu
                85                  90                  95      
Ser Pro Gln Asp Ile Asn Thr Lys Trp Asp Met Val Arg Lys Leu Val
            100                 105                 110         
Pro Ser Arg Asp Gln Thr Leu Gln Glu Glu Leu Ala Arg Gln Gln Val
        115                 120                 125             
Asn Glu Arg Leu Arg Arg Gln Phe Ala Ala Gln Ala Asn Ala Ile Gly
    130                 135                 140                 
Pro Trp Ile Gln Ala Lys Val Glu Glu Val Gly Arg Leu Ala Ala Gly
145                 150                 155                 160 
Leu Ala Gly Ser Leu Glu Glu Gln Met Ala Gly Leu Arg Gln Gln Glu
                165                 170                 175     
Gln Asn Ile Ile Asn Tyr Lys Thr Asn Ile Asp Arg Leu Glu Gly Asp
            180                 185                 190         
His Gln Leu Leu Gln Glu Ser Leu Val Phe Asp Asn Lys His Thr Val
        195                 200                 205             
Tyr Ser Met Glu His Ile Arg Val Gly Trp Glu Gln Leu Leu Thr Ser
    210                 215                 220                 
Ile Ala Arg Thr Ile Asn Glu Val Glu Asn Gln Val Leu Thr Arg Asp
225                 230                 235                 240 
Ala Lys Gly Leu Ser Gln Glu Gln Leu Asn Glu Phe Arg Ala Ser Phe
                245                 250                 255     
Asn His Phe Asp Arg Lys Arg Asn Gly Met Met Glu Pro Asp Asp Phe
            260                 265                 270         
Arg Ala Cys Leu Ile Ser Met Gly Tyr Asp Leu Gly Glu Val Glu Phe
        275                 280                 285             
Ala Arg Ile Met Thr Met Val Asp Pro Asn Ala Ala Gly Val Val Thr
    290                 295                 300                 
Phe Gln Ala Phe Ile Asp Phe Met Thr Arg Glu Thr Ala Glu Thr Asp
305                 310                 315                 320 
Thr Thr Glu Gln Val Val Ala Ser Phe Lys Ile Leu Ala Gly Asp Lys
                325                 330                 335     
Asn Tyr Ile Thr Pro Glu Glu Leu Arg Pro Ser Pro Leu Pro Ser Arg
            340                 345                 350         
Pro Ser Thr Ala Ser Ala Val Trp Cys Pro Thr Arg Asp Pro Gly Pro
        355                 360                 365             
Arg Leu Glu Pro Trp Thr Thr Trp Pro Ser Pro Val Pro Ser Met Gly
    370                 375                 380                 
Arg Ala Thr Phe Asp Pro Asn His
385                 390         


<210> 1247
<211> 499
<212> PRT
<213> Homo sapiens

<400> 1247
Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe
 1               5                  10                  15      
Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro
            20                  25                  30          
Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe
        35                  40                  45              
Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr
    50                  55                  60                  
Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr
65                  70                  75                  80  
Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu
                85                  90                  95      
Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu
            100                 105                 110         
Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp
        115                 120                 125             
Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu
    130                 135                 140                 
Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys
145                 150                 155                 160 
His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys
                165                 170                 175     
Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys
            180                 185                 190         
Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu
        195                 200                 205             
Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val
    210                 215                 220                 
Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe
225                 230                 235                 240 
Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser
                245                 250                 255     
Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu
            260                 265                 270         
Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe
        275                 280                 285             
Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln
    290                 295                 300                 
Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala
305                 310                 315                 320 
Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr
                325                 330                 335     
Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys
            340                 345                 350         
Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser
        355                 360                 365             
Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser
    370                 375                 380                 
Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro
385                 390                 395                 400 
Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe
                405                 410                 415     
Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu
            420                 425                 430         
Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys
        435                 440                 445             
His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp
    450                 455                 460                 
Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr
465                 470                 475                 480 
Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala
                485                 490                 495     
Leu Gly Leu
            


<210> 1248
<211> 473
<212> PRT
<213> Homo sapiens

<400> 1248
Met Arg Leu Leu Glu Ser Lys Lys Gly Leu Ser Phe Phe Ala Phe Glu
 1               5                  10                  15      
His Ser Glu Glu Tyr Gln Gln Ala Gln His Lys Phe Leu Val Ala Val
            20                  25                  30          
Glu Ser Met Glu Pro Asn Asn Ile Val Val Leu Leu Gln Thr Ser Pro
        35                  40                  45              
Tyr His Val Asp Ser Leu Leu Gln Leu Ser Asp Ala Cys Arg Phe Gln
    50                  55                  60                  
Glu Asp Gln Glu Met Ala Arg Asp Leu Val Glu Arg Ala Leu Tyr Ser
65                  70                  75                  80  
Met Glu Cys Ala Phe His Pro Leu Phe Ser Leu Thr Ser Gly Ala Cys
                85                  90                  95      
Arg Leu Asp Tyr Arg Arg Pro Glu Asn Arg Ser Phe Tyr Leu Ala Leu
            100                 105                 110         
Tyr Lys Gln Met Ser Phe Leu Glu Lys Arg Gly Cys Pro Arg Thr Ala
        115                 120                 125             
Leu Glu Tyr Cys Lys Leu Ile Leu Ser Leu Glu Pro Asp Glu Asp Pro
    130                 135                 140                 
Leu Cys Met Leu Leu Leu Ile Asp His Leu Ala Leu Arg Ala Arg Asn
145                 150                 155                 160 
Tyr Glu Tyr Leu Ile Arg Leu Phe Gln Glu Trp Glu Ala His Arg Asn
                165                 170                 175     
Leu Ser Gln Leu Pro Asn Phe Ala Phe Ser Val Pro Leu Ala Tyr Phe
            180                 185                 190         
Leu Leu Ser Gln Gln Thr Asp Leu Pro Glu Cys Glu Gln Ser Ser Ala
        195                 200                 205             
Arg Gln Lys Ala Ser Leu Leu Ile Gln Gln Ala Leu Thr Met Phe Pro
    210                 215                 220                 
Gly Val Leu Leu Pro Leu Leu Glu Ser Cys Ser Val Arg Pro Asp Ala
225                 230                 235                 240 
Ser Val Ser Ser His Arg Phe Phe Gly Pro Asn Ala Glu Ile Ser Gln
                245                 250                 255     
Pro Pro Ala Leu Ser Gln Leu Val Asn Leu Tyr Leu Gly Arg Ser His
            260                 265                 270         
Phe Leu Trp Lys Glu Pro Ala Thr Met Ser Trp Leu Glu Glu Asn Val
        275                 280                 285             
His Glu Val Leu Gln Ala Val Asp Ala Gly Asp Pro Ala Val Glu Ala
    290                 295                 300                 
Cys Glu Asn Arg Arg Lys Val Leu Tyr Gln Arg Ala Pro Arg Asn Ile
305                 310                 315                 320 
His Arg His Val Ile Leu Ser Glu Ile Lys Glu Ala Val Ala Ala Leu
                325                 330                 335     
Pro Pro Asp Val Thr Thr Gln Ser Val Met Gly Phe Asp Pro Leu Pro
            340                 345                 350         
Pro Ser Asp Thr Ile Tyr Ser Tyr Val Arg Pro Glu Arg Lys Gly Glu
        355                 360                 365             
Glu Glu Arg Asn Ser Val Ile Trp Gly Ser Gln Leu Cys Val Cys Arg
    370                 375                 380                 
Pro Arg Ser Phe Pro Ser Pro Pro Asn Val Gln Ala Leu Ala Cys Arg
385                 390                 395                 400 
Pro Leu Trp Gln Ala Lys Ser Tyr Gln Pro Trp Lys His His Cys Ser
                405                 410                 415     
Leu Leu Pro Val Thr Val Ala Lys Leu Tyr His Gly Gly Gly Glu Ala
            420                 425                 430         
Arg Gly Arg Ser Gly Trp Gly Ser Glu Pro Gln Pro Gly Pro Glu Gln
        435                 440                 445             
Ala Asp Ala Gly Cys Ala Arg His Asp Gly Gln Leu Pro Pro Gln Arg
    450                 455                 460                 
Pro Gly Gly Ala Ala Arg Gly Arg Arg
465                 470             


<210> 1249
<211> 298
<212> PRT
<213> Homo sapiens

<400> 1249
Met Arg Ala Glu Met Pro Asn Gly Leu Arg Pro Leu Leu Trp Leu Ala
 1               5                  10                  15      
Gly Leu Leu Gly Ala Gly Gly Thr Val Ser Val Val Tyr Ile Phe Gly
            20                  25                  30          
Asn Asn Pro Val Asp Glu Asn Gly Ala Lys Ile Pro Asp Glu Phe Asp
        35                  40                  45              
Asn Asp Pro Ile Leu Val Gln Gln Leu Arg Arg Thr Tyr Lys Tyr Phe
    50                  55                  60                  
Lys Asp Tyr Arg Gln Met Ile Ile Glu Pro Thr Ser Pro Cys Leu Leu
65                  70                  75                  80  
Pro Asp Pro Leu Gln Glu Pro Tyr Tyr Gln Pro Pro Tyr Thr Leu Val
                85                  90                  95      
Leu Glu Leu Thr Gly Val Leu Leu His Pro Glu Trp Ser Leu Ala Thr
            100                 105                 110         
Gly Trp Arg Phe Lys Lys Arg Pro Gly Ile Glu Thr Leu Phe Gln Gln
        115                 120                 125             
Leu Ala Pro Leu Tyr Glu Ile Val Ile Phe Thr Ser Glu Thr Gly Met
    130                 135                 140                 
Thr Ala Phe Pro Leu Ile Asp Ser Val Asp Pro His Gly Phe Ile Ser
145                 150                 155                 160 
Tyr Arg Leu Phe Arg Asp Ala Thr Arg Tyr Met Asp Gly His His Val
                165                 170                 175     
Lys Asp Ile Ser Cys Leu Asn Arg Asp Pro Ala Arg Val Val Val Val
            180                 185                 190         
Asp Cys Lys Lys Glu Ala Phe Arg Leu Gln Pro Tyr Asn Gly Val Ala
        195                 200                 205             
Leu Arg Pro Trp Asp Gly Asn Ser Asp Asp Arg Val Leu Leu Asp Leu
    210                 215                 220                 
Ser Ala Phe Leu Lys Thr Ile Ala Leu Asn Gly Val Glu Asp Val Arg
225                 230                 235                 240 
Thr Val Leu Glu His Tyr Ala Leu Glu Asp Asp Pro Leu Ala Ala Phe
                245                 250                 255     
Lys Gln Arg Gln Ser Arg Leu Glu Gln Glu Glu Gln Gln Arg Leu Ala
            260                 265                 270         
Glu Leu Ser Lys Ser Asn Lys Gln Asn Leu Phe Leu Gly Ser Leu Thr
        275                 280                 285             
Ser Arg Leu Trp Pro Arg Ser Lys Gln Pro
    290                 295             


<210> 1250
<211> 126
<212> PRT
<213> Homo sapiens

<400> 1250
Met Asn Lys His Asn Leu Arg Leu Val Gln Leu Ala Ser Glu Leu Ile
 1               5                  10                  15      
Leu Ile Glu Ile Ile Pro Lys Leu Phe Leu Ser Gln Val Thr Thr Ile
            20                  25                  30          
Ser His Ile Lys Arg Glu Lys Ile Pro Pro Asn His Arg Lys Gly Ile
        35                  40                  45              
Leu Cys Met Phe Pro Trp Gln Cys Val Val Tyr Val Phe Ser Asn Phe
    50                  55                  60                  
Val Trp Leu Val Ile His Arg Phe Ser Asn Gly Phe Ile Gln Phe Leu
65                  70                  75                  80  
Gly Glu Pro Tyr Arg Leu Met Thr Ala Ser Gly Thr His Gly Arg Ile
                85                  90                  95      
Lys Phe Met Val Asp Ile Pro Ile Ile Lys Asn Thr Gln Val Leu Arg
            100                 105                 110         
Ile Pro Val Leu Lys Asp Pro Lys Met Leu Ser Lys Lys His
        115                 120                 125     


<210> 1251
<211> 405
<212> PRT
<213> Homo sapiens

<400> 1251
Met Asp Ser Ala Ile Thr Leu Trp Gln Phe Leu Leu Gln Leu Leu Gln
 1               5                  10                  15      
Lys Pro Gln Asn Lys His Met Ile Cys Trp Thr Ser Asn Asp Gly Gln
            20                  25                  30          
Phe Lys Leu Leu Gln Ala Glu Glu Val Ala Arg Leu Trp Gly Ile Arg
        35                  40                  45              
Lys Asn Lys Pro Asn Met Asn Tyr Asp Lys Leu Ser Arg Ala Leu Arg
    50                  55                  60                  
Tyr Tyr Tyr Val Lys Asn Ile Ile Lys Lys Val Asn Gly Gln Lys Phe
65                  70                  75                  80  
Val Tyr Lys Phe Val Ser Tyr Pro Glu Ile Leu Asn Met Asp Pro Met
                85                  90                  95      
Thr Val Gly Arg Ile Glu Gly Asp Cys Glu Ser Leu Asn Phe Ser Glu
            100                 105                 110         
Val Ser Ser Ser Ser Lys Asp Val Glu Asn Gly Gly Lys Asp Lys Pro
        115                 120                 125             
Pro Gln Pro Gly Ala Lys Thr Ser Ser Arg Asn Asp Tyr Ile His Ser
    130                 135                 140                 
Gly Leu Tyr Ser Ser Phe Thr Leu Asn Ser Leu Asn Ser Ser Asn Val
145                 150                 155                 160 
Lys Leu Phe Lys Leu Ile Lys Thr Glu Asn Pro Ala Glu Lys Leu Ala
                165                 170                 175     
Glu Lys Lys Ser Pro Gln Glu Pro Thr Pro Ser Val Ile Lys Phe Val
            180                 185                 190         
Thr Thr Pro Ser Lys Lys Pro Pro Val Glu Pro Val Ala Ala Thr Ile
        195                 200                 205             
Ser Ile Gly Pro Ser Ile Ser Pro Ser Ser Glu Glu Thr Ile Gln Ala
    210                 215                 220                 
Leu Glu Thr Leu Val Ser Pro Lys Leu Pro Ser Leu Glu Ala Pro Thr
225                 230                 235                 240 
Ser Ala Ser Asn Val Met Thr Ala Phe Ala Thr Thr Pro Pro Ile Ser
                245                 250                 255     
Ser Ile Pro Pro Leu Gln Glu Pro Pro Arg Thr Pro Ser Pro Pro Leu
            260                 265                 270         
Ser Ser His Pro Asp Ile Asp Thr Asp Ile Asp Ser Val Ala Ser Gln
        275                 280                 285             
Pro Met Glu Leu Pro Glu Asn Leu Ser Leu Glu Pro Lys Asp Gln Asp
    290                 295                 300                 
Ser Val Leu Leu Glu Lys Asp Lys Val Asn Asn Ser Ser Arg Ser Lys
305                 310                 315                 320 
Lys Pro Lys Gly Leu Glu Leu Ala Pro Thr Leu Val Ile Thr Ser Ser
                325                 330                 335     
Asp Pro Ser Pro Leu Gly Ile Leu Ser Pro Ser Leu Pro Thr Ala Ser
            340                 345                 350         
Leu Thr Pro Ala Phe Phe Ser Gln Val Ala Cys Ser Leu Phe Met Val
        355                 360                 365             
Ser Pro Leu Leu Ser Phe Ile Cys Pro Phe Lys Gln Ile Gln Asn Leu
    370                 375                 380                 
Tyr Thr Gln Val Cys Phe Leu Leu Leu Arg Phe Val Leu Glu Arg Leu
385                 390                 395                 400 
Cys Val Thr Val Met
                405 


<210> 1252
<211> 820
<212> PRT
<213> Homo sapiens

<400> 1252
Met Lys Met Leu Leu Leu Leu His Cys Leu Gly Val Phe Leu Ser Cys
 1               5                  10                  15      
Ser Gly His Ile Gln Asp Glu His Pro Gln Tyr His Ser Pro Pro Asp
            20                  25                  30          
Val Val Ile Pro Val Arg Ile Thr Gly Thr Thr Arg Gly Met Thr Pro
        35                  40                  45              
Pro Gly Trp Leu Ser Tyr Ile Leu Pro Phe Gly Gly Gln Lys His Ile
    50                  55                  60                  
Ile His Ile Lys Val Lys Lys Leu Leu Phe Ser Lys His Leu Pro Val
65                  70                  75                  80  
Phe Thr Tyr Thr Asp Gln Gly Ala Ile Leu Glu Asp Gln Pro Phe Val
                85                  90                  95      
Gln Asn Asn Cys Tyr Tyr His Gly Tyr Val Glu Gly Asp Pro Glu Ser
            100                 105                 110         
Leu Val Ser Leu Ser Thr Cys Phe Gly Gly Phe Gln Gly Ile Leu Gln
        115                 120                 125             
Ile Asn Asp Phe Ala Tyr Glu Ile Lys Pro Leu Ala Phe Ser Thr Thr
    130                 135                 140                 
Phe Glu His Leu Val Tyr Lys Met Asp Ser Glu Glu Lys Gln Phe Ser
145                 150                 155                 160 
Thr Met Arg Ser Gly Phe Met Gln Asn Glu Ile Thr Cys Arg Met Glu
                165                 170                 175     
Phe Glu Glu Ile Asp Asn Ser Thr Gln Lys Gln Ser Ser Tyr Val Gly
            180                 185                 190         
Trp Trp Ile His Phe Arg Ile Val Glu Ile Val Val Val Ile Asp Asn
        195                 200                 205             
Tyr Leu Tyr Ile Arg Tyr Glu Arg Asn Asp Ser Lys Leu Leu Glu Asp
    210                 215                 220                 
Leu Tyr Val Ile Val Asn Ile Val Asp Ser Ile Leu Asp Val Ile Gly
225                 230                 235                 240 
Val Lys Val Leu Leu Phe Gly Leu Glu Ile Trp Thr Asn Lys Asn Leu
                245                 250                 255     
Ile Val Val Asp Asp Val Arg Lys Ser Val His Leu Tyr Cys Lys Trp
            260                 265                 270         
Lys Ser Glu Asn Ile Thr Pro Arg Met Gln His Asp Thr Ser His Leu
        275                 280                 285             
Phe Thr Thr Leu Gly Leu Arg Gly Leu Ser Gly Ile Gly Ala Phe Arg
    290                 295                 300                 
Gly Met Cys Thr Pro His Arg Ser Cys Ala Ile Val Thr Phe Met Asn
305                 310                 315                 320 
Lys Thr Leu Gly Thr Phe Ser Ile Ala Val Ala His His Leu Gly His
                325                 330                 335     
Asn Leu Gly Met Asn His Asp Glu Asp Thr Cys Arg Cys Ser Gln Pro
            340                 345                 350         
Arg Cys Ile Met His Glu Gly Asn Pro Pro Ile Thr Lys Phe Ser Asn
        355                 360                 365             
Cys Ser Tyr Gly Asp Phe Trp Glu Tyr Thr Val Glu Arg Thr Lys Cys
    370                 375                 380                 
Leu Leu Glu Thr Val His Thr Lys Asp Ile Phe Asn Val Lys Arg Cys
385                 390                 395                 400 
Gly Asn Gly Val Val Glu Glu Gly Glu Glu Cys Asp Cys Gly Pro Leu
                405                 410                 415     
Lys His Cys Ala Lys Asp Pro Cys Cys Leu Ser Asn Cys Thr Leu Thr
            420                 425                 430         
Asp Gly Ser Thr Cys Ala Phe Gly Leu Cys Cys Lys Asp Cys Lys Phe
        435                 440                 445             
Leu Pro Ser Gly Lys Val Cys Arg Lys Glu Val Asn Glu Cys Asp Leu
    450                 455                 460                 
Pro Glu Trp Cys Asn Gly Thr Ser His Lys Cys Pro Asp Asp Phe Tyr
465                 470                 475                 480 
Val Glu Asp Gly Ile Pro Cys Lys Glu Arg Gly Tyr Cys Tyr Glu Lys
                485                 490                 495     
Ser Cys His Asp Arg Asn Glu Gln Cys Arg Arg Ile Phe Gly Ala Gly
            500                 505                 510         
Ala Asn Thr Ala Ser Glu Thr Cys Tyr Lys Glu Leu Asn Thr Leu Gly
        515                 520                 525             
Asp Arg Val Gly His Cys Gly Ile Lys Asn Ala Thr Tyr Ile Lys Cys
    530                 535                 540                 
Asn Ile Ser Asp Val Gln Cys Gly Arg Ile Gln Cys Glu Asn Val Thr
545                 550                 555                 560 
Glu Ile Pro Asn Met Ser Asp His Thr Thr Val His Trp Ala Arg Phe
                565                 570                 575     
Asn Asp Ile Met Cys Trp Ser Thr Asp Tyr His Leu Gly Met Lys Gly
            580                 585                 590         
Pro Asp Ile Gly Glu Val Lys Asp Gly Thr Glu Cys Gly Ile Asp His
        595                 600                 605             
Ile Cys Ile His Arg His Cys Val His Ile Thr Ile Leu Asn Ser Asn
    610                 615                 620                 
Cys Ser Pro Ala Phe Cys Asn Lys Arg Gly Ile Cys Asn Asn Lys His
625                 630                 635                 640 
His Cys His Cys Asn Tyr Leu Trp Asp Pro Pro Asn Cys Leu Ile Lys
                645                 650                 655     
Gly Tyr Gly Gly Ser Val Asp Ser Gly Pro Pro Pro Lys Arg Lys Lys
            660                 665                 670         
Lys Lys Lys Phe Cys Tyr Leu Cys Ile Leu Leu Leu Ile Val Leu Phe
        675                 680                 685             
Ile Leu Leu Cys Cys Leu Tyr Arg Leu Cys Lys Lys Ser Lys Pro Ile
    690                 695                 700                 
Lys Lys Gln Gln Asp Val Gln Thr Pro Ser Ala Lys Glu Glu Glu Lys
705                 710                 715                 720 
Ile Gln Arg Arg Pro His Glu Leu Pro Pro Gln Ser Gln Pro Trp Val
                725                 730                 735     
Met Pro Ser Gln Ser Gln Pro Pro Val Thr Pro Ser Gln Ser His Pro
            740                 745                 750         
Arg Val Met Pro Ser Gln Ser Gln Pro Pro Val Met Pro Ser Gln Ser
        755                 760                 765             
His Pro Gln Leu Thr Pro Ser Gln Ser Gln Pro Pro Val Met Pro Ser
    770                 775                 780                 
Gln Ser His Pro Gln Leu Thr Pro Ser Gln Ser Gln Pro Pro Val Thr
785                 790                 795                 800 
Pro Ser Gln Arg Gln Pro Gln Leu Met Pro Ser Gln Ser Gln Pro Pro
                805                 810                 815     
Val Thr Pro Ser
            820 


<210> 1253
<211> 108
<212> PRT
<213> Homo sapiens

<400> 1253
Met Ile Leu Gln Arg Leu Phe Arg Phe Ser Ser Val Ile Arg Ser Ala
 1               5                  10                  15      
Val Ser Val His Leu Arg Arg Asn Ile Gly Val Thr Ala Val Ala Phe
            20                  25                  30          
Asn Lys Glu Leu Asp Pro Ile Gln Lys Leu Phe Val Asp Lys Ile Arg
        35                  40                  45              
Glu Tyr Lys Ser Lys Arg Gln Thr Ser Gly Gly Pro Val Asp Ala Ser
    50                  55                  60                  
Ser Glu Tyr Gln Gln Glu Leu Glu Arg Glu Leu Phe Lys Leu Lys Gln
65                  70                  75                  80  
Met Phe Gly Asn Ala Asp Met Asn Thr Phe Pro Thr Phe Lys Phe Glu
                85                  90                  95      
Asp Pro Lys Phe Glu Val Ile Glu Lys Pro Gln Ala
            100                 105             


<210> 1254
<211> 210
<212> PRT
<213> Homo sapiens

<400> 1254
Met Trp Thr Leu Gly Arg Arg Ala Val Ala Gly Leu Leu Ala Ser Pro
 1               5                  10                  15      
Ser Pro Ala Gln Ala Gln Thr Leu Thr Arg Val Pro Arg Pro Ala Glu
            20                  25                  30          
Leu Ala Pro Leu Cys Gly Arg Arg Gly Leu Arg Thr Asp Ile Asp Ala
        35                  40                  45              
Thr Cys Thr Pro Arg Arg Ala Ser Ser Asn Gln Arg Gly Leu Asn Gln
    50                  55                  60                  
Ile Trp Asn Val Lys Lys Gln Ser Val Tyr Leu Met Asn Leu Arg Lys
65                  70                  75                  80  
Ser Gly Thr Leu Gly His Pro Gly Ser Leu Asp Glu Thr Thr Tyr Glu
                85                  90                  95      
Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp
            100                 105                 110         
Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly
        115                 120                 125             
Ser Gly Val Leu Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr Val
    130                 135                 140                 
Ile Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro Ser
145                 150                 155                 160 
Ser Gly Pro Lys Arg Tyr Asp Trp Thr Gly Lys Asn Trp Val Tyr Ser
                165                 170                 175     
His Asp Gly Val Ser Leu His Glu Leu Leu Ala Ala Glu Leu Thr Lys
            180                 185                 190         
Ala Leu Lys Thr Lys Leu Asp Leu Ser Ser Leu Ala Tyr Ser Gly Lys
        195                 200                 205             
Asp Ala
    210 


<210> 1255
<211> 442
<212> PRT
<213> Homo sapiens

<400> 1255
Met Ala Gly Ala Ala Thr Gly Ser Arg Thr Pro Gly Arg Ser Glu Leu
 1               5                  10                  15      
Val Glu Gly Cys Gly Trp Arg Cys Pro Glu His Gly Asp Arg Val Ala
            20                  25                  30          
Glu Leu Phe Cys Arg Arg Cys Arg Arg Cys Val Cys Ala Leu Cys Pro
        35                  40                  45              
Val Leu Gly Ala His Arg Gly His Pro Val Gly Leu Ala Leu Glu Ala
    50                  55                  60                  
Ala Val His Val Gln Lys Leu Ser Gln Glu Cys Leu Lys Gln Leu Ala
65                  70                  75                  80  
Ile Lys Lys Gln Gln His Ile Asp Asn Ile Thr Gln Ile Glu Asp Ala
                85                  90                  95      
Thr Glu Lys Leu Lys Ala Asn Ala Glu Ser Ser Lys Thr Trp Leu Lys
            100                 105                 110         
Gly Lys Phe Thr Glu Leu Arg Leu Leu Leu Asp Glu Glu Glu Ala Leu
        115                 120                 125             
Ala Lys Lys Phe Ile Asp Lys Asn Thr Gln Leu Thr Leu Gln Val Tyr
    130                 135                 140                 
Arg Glu Gln Ala Asp Ser Cys Arg Glu Gln Leu Asp Ile Met Asn Asp
145                 150                 155                 160 
Leu Ser Asn Arg Val Trp Ser Ile Ser Gln Glu Pro Asp Pro Val Gln
                165                 170                 175     
Arg Leu Gln Ala Tyr Thr Ala Thr Glu Gln Glu Met Gln Gln Gln Met
            180                 185                 190         
Ser Leu Gly Glu Leu Cys His Pro Val Pro Leu Ser Phe Glu Pro Val
        195                 200                 205             
Lys Ser Phe Phe Lys Gly Leu Val Glu Ala Val Glu Ser Thr Leu Gln
    210                 215                 220                 
Thr Pro Leu Asp Ile Arg Leu Lys Glu Ser Ile Asn Cys Gln Leu Ser
225                 230                 235                 240 
Asp Pro Ser Ser Thr Lys Pro Gly Thr Leu Leu Lys Thr Ser Pro Ser
                245                 250                 255     
Pro Glu Arg Ser Leu Leu Leu Lys Tyr Ala Arg Thr Pro Thr Leu Asp
            260                 265                 270         
Pro Asp Thr Met His Ala Arg Leu Arg Leu Ser Ala Asp Arg Leu Thr
        275                 280                 285             
Val Arg Cys Gly Leu Leu Gly Ser Leu Gly Pro Val Pro Val Leu Arg
    290                 295                 300                 
Phe Asp Ala Leu Trp Gln Val Leu Ala Arg Asp Cys Phe Ala Thr Gly
305                 310                 315                 320 
Arg His Tyr Trp Glu Val Asp Val Gln Glu Ala Gly Ala Gly Trp Trp
                325                 330                 335     
Val Gly Ala Ala Tyr Ala Ser Leu Arg Arg Arg Gly Ala Ser Ala Ala
            340                 345                 350         
Ala Arg Leu Gly Cys Asn Arg Gln Ser Trp Cys Leu Lys Arg Tyr Asp
        355                 360                 365             
Leu Glu Tyr Trp Ala Phe His Asp Gly Gln Arg Ser Arg Leu Arg Pro
    370                 375                 380                 
Arg Asp Asp Leu Asp Arg Leu Gly Val Phe Leu Asp Tyr Glu Ala Gly
385                 390                 395                 400 
Val Leu Ala Phe Tyr Asp Val Thr Gly Gly Met Ser His Leu His Thr
                405                 410                 415     
Phe Arg Ala Thr Phe Gln Glu Pro Leu Tyr Pro Ala Leu Arg Leu Trp
            420                 425                 430         
Glu Gly Ala Ile Ser Ile Pro Arg Leu Pro
        435                 440         


<210> 1256
<211> 493
<212> PRT
<213> Homo sapiens

<400> 1256
Met Ser Lys Gly Pro Ala Val Gly Ile Asp Leu Gly Thr Thr Tyr Ser
 1               5                  10                  15      
Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp
            20                  25                  30          
Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu
        35                  40                  45              
Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Met Asn Pro Thr
    50                  55                  60                  
Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Arg Phe Asp Asp
65                  70                  75                  80  
Ala Val Val Gln Ser Asp Met Lys His Trp Pro Phe Met Val Val Asn
                85                  90                  95      
Asp Ala Gly Arg Pro Lys Val Gln Val Glu Tyr Lys Gly Glu Thr Lys
            100                 105                 110         
Ser Phe Tyr Pro Glu Glu Val Ser Ser Met Val Leu Thr Lys Met Lys
        115                 120                 125             
Glu Ile Ala Glu Ala Tyr Leu Gly Lys Thr Val Thr Asn Ala Val Val
    130                 135                 140                 
Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp
145                 150                 155                 160 
Ala Gly Thr Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro
                165                 170                 175     
Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Lys Lys Val Gly Ala Glu
            180                 185                 190         
Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser
        195                 200                 205             
Ile Leu Thr Ile Glu Asp Gly Ile Phe Glu Val Lys Ser Thr Ala Gly
    210                 215                 220                 
Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Met Val Asn His
225                 230                 235                 240 
Phe Ile Ala Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Glu Asn
                245                 250                 255     
Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg
            260                 265                 270         
Thr Leu Ser Ser Ser Thr Gln Ala Ser Ile Glu Ile Asp Ser Leu Tyr
        275                 280                 285             
Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu
    290                 295                 300                 
Leu Asn Ala Asp Leu Phe Arg Gly Thr Leu Asp Pro Val Glu Lys Ala
305                 310                 315                 320 
Leu Arg Asp Ala Lys Leu Asp Lys Ser Gln Ile His Asp Ile Val Leu
                325                 330                 335     
Val Gly Gly Ser Thr Arg Ile Pro Lys Ile Gln Lys Leu Leu Gln Asp
            340                 345                 350         
Phe Phe Asn Gly Lys Glu Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala
        355                 360                 365             
Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Ser Gly Asp Lys
    370                 375                 380                 
Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Thr Pro Leu Ser
385                 390                 395                 400 
Leu Gly Ile Glu Thr Ala Gly Gly Val Met Thr Val Leu Ile Lys Arg
                405                 410                 415     
Asn Thr Thr Ile Pro Thr Lys Gln Thr Gln Thr Phe Thr Thr Tyr Ser
            420                 425                 430         
Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala
        435                 440                 445             
Met Thr Lys Asp Asn Asn Leu Leu Gly Lys Phe Glu Leu Thr Gly Met
    450                 455                 460                 
Pro Gly Gly Met Pro Gly Gly Phe Pro Gly Gly Gly Ala Pro Pro Ser
465                 470                 475                 480 
Gly Gly Ala Ser Ser Gly Pro Thr Ile Glu Glu Val Asp
                485                 490             


<210> 1257
<211> 334
<212> PRT
<213> Homo sapiens

<400> 1257
Met Ser Ala Leu Leu Arg Leu Leu Arg Thr Val Ala Pro Ala Ala Ala
 1               5                  10                  15      
Cys Leu Arg Leu Gly Thr Ser Ala Gly Thr Gly Ser Arg Arg Ala Met
            20                  25                  30          
Ala Leu Tyr His Thr Glu Glu Arg Gly Gln Pro Cys Ser Gln Asn Tyr
        35                  40                  45              
Arg Leu Phe Phe Lys Asn Val Thr Gly His Tyr Ile Ser Pro Phe His
    50                  55                  60                  
Asp Ile Pro Leu Lys Val Asn Ser Lys Glu Glu Asn Gly Ile Pro Met
65                  70                  75                  80  
Lys Lys Ala Arg Asn Asp Glu Tyr Glu Asn Leu Phe Asn Met Ile Val
                85                  90                  95      
Glu Ile Pro Arg Trp Thr Asn Ala Lys Met Glu Ile Ala Thr Lys Glu
            100                 105                 110         
Pro Met Asn Pro Ile Lys Gln Tyr Val Lys Asp Gly Lys Leu Arg Tyr
        115                 120                 125             
Val Ala Asn Ile Phe Pro Tyr Lys Gly Tyr Ile Trp Asn Tyr Gly Thr
    130                 135                 140                 
Leu Pro Gln Thr Trp Glu Asp Pro His Glu Lys Asp Lys Ser Thr Asn
145                 150                 155                 160 
Cys Phe Gly Asp Asn Asp Pro Ile Asp Val Cys Glu Ile Gly Ser Lys
                165                 170                 175     
Ile Leu Ser Cys Gly Glu Val Ile His Val Lys Ile Leu Gly Ile Leu
            180                 185                 190         
Ala Leu Ile Asp Glu Gly Glu Thr Asp Trp Lys Leu Ile Ala Ile Asn
        195                 200                 205             
Ala Asn Asp Pro Glu Ala Ser Lys Phe His Asp Ile Asp Asp Val Lys
    210                 215                 220                 
Lys Phe Lys Pro Gly Tyr Leu Glu Ala Thr Leu Asn Trp Phe Arg Leu
225                 230                 235                 240 
Tyr Lys Val Pro Asp Gly Lys Pro Glu Asn Gln Phe Ala Phe Asn Gly
                245                 250                 255     
Glu Phe Lys Asn Lys Ala Phe Ala Leu Glu Val Ile Lys Ser Thr His
            260                 265                 270         
Gln Cys Trp Lys Ala Leu Leu Met Lys Lys Cys Asn Gly Gly Ala Ile
        275                 280                 285             
Asn Cys Thr Asn Val Gln Ile Ser Asp Ser Pro Phe Arg Cys Thr Gln
    290                 295                 300                 
Glu Glu Ala Arg Ser Leu Val Glu Ser Val Ser Ser Ser Pro Asn Lys
305                 310                 315                 320 
Glu Ser Asn Glu Glu Glu Gln Val Trp His Phe Leu Gly Lys
                325                 330                 


<210> 1258
<211> 430
<212> PRT
<213> Homo sapiens

<400> 1258
Met Ser Ser Arg Ser Pro Arg Pro Pro Pro Arg Arg Ser Arg Arg Arg
 1               5                  10                  15      
Leu Pro Arg Pro Ser Cys Cys Cys Cys Cys Cys Arg Arg Ser His Leu
            20                  25                  30          
Asn Glu Asp Thr Gly Arg Phe Val Leu Leu Ala Ala Leu Ile Gly Leu
        35                  40                  45              
Tyr Leu Val Ala Gly Ala Thr Val Phe Ser Ala Leu Glu Ser Pro Gly
    50                  55                  60                  
Glu Ala Glu Ala Arg Ala Arg Trp Gly Ala Thr Leu Arg Asn Phe Ser
65                  70                  75                  80  
Ala Ala His Gly Val Ala Glu Pro Glu Leu Arg Ala Phe Leu Arg His
                85                  90                  95      
Tyr Glu Ala Ala Leu Ala Ala Gly Val Arg Ala Asp Ala Leu Arg Pro
            100                 105                 110         
Arg Trp Asp Phe Pro Gly Ala Phe Tyr Phe Val Gly Thr Val Val Ser
        115                 120                 125             
Thr Ile Gly Phe Gly Met Thr Thr Pro Ala Thr Val Gly Gly Lys Ala
    130                 135                 140                 
Phe Leu Ile Ala Tyr Gly Leu Phe Gly Cys Ala Gly Thr Ile Leu Phe
145                 150                 155                 160 
Phe Asn Leu Phe Leu Glu Arg Ile Ile Ser Leu Leu Ala Phe Ile Met
                165                 170                 175     
Arg Ala Cys Arg Glu Arg Gln Leu Arg Arg Ser Gly Leu Leu Pro Ala
            180                 185                 190         
Thr Phe Arg Arg Gly Ser Ala Leu Ser Glu Ala Asp Ser Leu Ala Gly
        195                 200                 205             
Trp Lys Pro Ser Val Tyr His Val Leu Leu Ile Leu Gly Leu Phe Ala
    210                 215                 220                 
Val Leu Leu Ser Cys Cys Ala Ser Ala Met Tyr Thr Ser Val Glu Gly
225                 230                 235                 240 
Trp Asp Tyr Val Asp Ser Leu Tyr Phe Cys Phe Val Thr Phe Ser Thr
                245                 250                 255     
Ile Gly Phe Gly Asp Leu Val Ser Ser Gln His Ala Ala Tyr Arg Asn
            260                 265                 270         
Gln Gly Leu Tyr Arg Leu Gly Asn Phe Leu Phe Ile Leu Leu Gly Val
        275                 280                 285             
Cys Cys Ile Tyr Ser Leu Phe Asn Val Ile Ser Ile Leu Ile Lys Gln
    290                 295                 300                 
Val Leu Asn Trp Met Leu Arg Lys Leu Ser Cys Arg Cys Cys Ala Arg
305                 310                 315                 320 
Cys Cys Pro Ala Pro Gly Ala Pro Leu Ala Arg Arg Asn Ala Ile Thr
                325                 330                 335     
Pro Gly Ser Arg Leu Arg Arg Arg Leu Ala Ala Leu Gly Ala Asp Pro
            340                 345                 350         
Ala Ala Arg Asp Ser Asp Ala Glu Gly Arg Arg Leu Ser Gly Glu Leu
        355                 360                 365             
Ile Ser Met Arg Asp Leu Thr Ala Ser Asn Lys Val Ser Leu Ala Leu
    370                 375                 380                 
Leu Gln Lys Gln Leu Ser Glu Thr Ala Asn Gly Tyr Pro Arg Ser Val
385                 390                 395                 400 
Cys Val Asn Thr Arg Gln Asn Gly Phe Ser Gly Gly Val Gly Ala Leu
                405                 410                 415     
Gly Ile Met Asn Asn Arg Leu Ala Glu Thr Ser Ala Ser Arg
            420                 425                 430 


<210> 1259
<211> 901
<212> PRT
<213> Homo sapiens

<400> 1259
Met Ala Pro Thr Lys Pro Ser Phe Gln Gln Asp Pro Ser Arg Arg Glu
 1               5                  10                  15      
Arg Leu Gln Ala Leu Arg Lys Glu Lys Ser Arg Asp Ala Ala Arg Ser
            20                  25                  30          
Arg Arg Gly Lys Glu Asn Phe Glu Phe Tyr Glu Leu Ala Lys Leu Leu
        35                  40                  45              
Pro Leu Pro Ala Ala Ile Thr Ser Gln Leu Asp Lys Ala Ser Ile Ile
    50                  55                  60                  
Arg Leu Thr Ile Ser Tyr Leu Lys Met Arg Asp Phe Ala Asn Gln Gly
65                  70                  75                  80  
Asp Pro Pro Trp Asn Leu Arg Met Glu Gly Pro Pro Pro Asn Thr Ser
                85                  90                  95      
Val Lys Gly Ala Gln Arg Arg Arg Ser Pro Ser Ala Leu Ala Ile Glu
            100                 105                 110         
Val Phe Glu Ala His Leu Gly Ser His Ile Leu Gln Ser Leu Asp Gly
        115                 120                 125             
Phe Val Phe Ala Leu Asn Gln Glu Gly Lys Phe Leu Tyr Ile Ser Glu
    130                 135                 140                 
Thr Val Ser Ile Tyr Leu Gly Leu Ser Gln Val Glu Leu Thr Gly Ser
145                 150                 155                 160 
Ser Val Phe Asp Tyr Val His Pro Gly Asp His Val Glu Met Ala Glu
                165                 170                 175     
Gln Leu Gly Met Lys Leu Pro Pro Gly Arg Gly Leu Leu Ser Gln Gly
            180                 185                 190         
Thr Ala Glu Asp Gly Ala Ser Ser Ala Ser Ser Ser Ser Gln Ser Glu
        195                 200                 205             
Thr Pro Glu Pro Val Glu Ser Thr Ser Pro Ser Leu Leu Thr Thr Asp
    210                 215                 220                 
Asn Thr Leu Glu Arg Ser Phe Phe Ile Arg Met Lys Ser Thr Leu Thr
225                 230                 235                 240 
Lys Arg Gly Val His Ile Lys Ser Ser Gly Tyr Lys Val Ile His Ile
                245                 250                 255     
Thr Gly Arg Leu Arg Leu Arg Val Ser Leu Ser His Gly Arg Thr Val
            260                 265                 270         
Pro Ser Gln Ile Met Gly Leu Val Val Val Ala His Ala Leu Pro Pro
        275                 280                 285             
Pro Thr Ile Asn Glu Val Arg Ile Asp Cys His Met Phe Val Thr Arg
    290                 295                 300                 
Val Asn Met Asp Leu Asn Ile Ile Tyr Cys Glu Asn Arg Ile Ser Asp
305                 310                 315                 320 
Tyr Met Asp Leu Thr Pro Val Asp Ile Val Gly Lys Arg Cys Tyr His
                325                 330                 335     
Phe Ile His Ala Glu Asp Val Glu Gly Ile Arg His Ser His Leu Asp
            340                 345                 350         
Leu Leu Asn Lys Gly Gln Cys Val Thr Lys Tyr Tyr Arg Trp Met Gln
        355                 360                 365             
Lys Asn Gly Gly Tyr Ile Trp Ile Gln Ser Ser Ala Thr Ile Ala Ile
    370                 375                 380                 
Asn Ala Lys Asn Ala Asn Glu Lys Asn Ile Ile Trp Val Asn Tyr Leu
385                 390                 395                 400 
Leu Ser Asn Pro Glu Tyr Lys Asp Thr Pro Met Asp Ile Ala Gln Leu
                405                 410                 415     
Pro His Leu Pro Glu Lys Thr Ser Glu Ser Ser Glu Thr Ser Asp Ser
            420                 425                 430         
Glu Ser Asp Ser Lys Asp Thr Ser Gly Ile Thr Glu Asp Asn Glu Asn
        435                 440                 445             
Ser Lys Ser Asp Glu Lys Gly Asn Gln Ser Glu Asn Ser Glu Asp Pro
    450                 455                 460                 
Glu Pro Asp Arg Lys Lys Ser Gly Asn Ala Cys Asp Asn Asp Met Asn
465                 470                 475                 480 
Cys Asn Asp Asp Gly His Ser Ser Ser Asn Pro Asp Ser Arg Asp Ser
                485                 490                 495     
Asp Asp Ser Phe Glu His Ser Asp Phe Glu Asn Pro Lys Ala Gly Glu
            500                 505                 510         
Asp Gly Phe Gly Ala Leu Gly Ala Met Gln Ile Lys Val Glu Arg Tyr
        515                 520                 525             
Val Glu Ser Glu Ser Asp Leu Arg Leu Gln Asn Cys Glu Ser Leu Thr
    530                 535                 540                 
Ser Asp Ser Ala Lys Asp Ser Asp Ser Ala Gly Glu Ala Gly Ala Gln
545                 550                 555                 560 
Ala Ser Ser Lys His Gln Lys Arg Lys Lys Arg Arg Lys Arg Gln Lys
                565                 570                 575     
Gly Gly Ser Ala Ser Arg Arg Arg Leu Ser Ser Ala Ser Ser Pro Gly
            580                 585                 590         
Gly Leu Asp Ala Gly Leu Val Glu Pro Pro Arg Leu Leu Ser Ser Pro
        595                 600                 605             
Asn Ser Ala Ser Val Leu Lys Ile Lys Thr Glu Ile Ser Glu Pro Ile
    610                 615                 620                 
Asn Phe Asp Asn Asp Ser Ser Ile Trp Asn Tyr Pro Pro Asn Arg Glu
625                 630                 635                 640 
Ile Ser Arg Asn Glu Ser Pro Tyr Ser Met Thr Lys Pro Pro Ser Ser
                645                 650                 655     
Glu His Phe Pro Ser Pro Gln Gly Gly Gly Gly Gly Gly Gly Gly Gly
            660                 665                 670         
Gly Gly Leu His Val Ala Ile Pro Asp Ser Val Leu Thr Pro Pro Gly
        675                 680                 685             
Ala Asp Gly Ala Ala Ala Arg Lys Thr Gln Phe Gly Ala Ser Ala Thr
    690                 695                 700                 
Ala Ala Leu Ala Pro Val Ala Ser Asp Pro Leu Ser Pro Pro Leu Ser
705                 710                 715                 720 
Ala Ser Pro Arg Asp Lys His Pro Gly Asn Gly Gly Gly Gly Gly Gly
                725                 730                 735     
Gly Gly Gly Gly Ala Gly Gly Gly Gly Pro Ser Ala Ser Asn Ser Leu
            740                 745                 750         
Leu Tyr Thr Gly Asp Leu Glu Ala Leu Gln Arg Leu Gln Ala Gly Asn
        755                 760                 765             
Val Val Leu Pro Leu Val His Arg Val Thr Gly Thr Leu Ala Ala Thr
    770                 775                 780                 
Ser Thr Ala Ala Gln Arg Val Tyr Thr Thr Gly Thr Ile Arg Tyr Ala
785                 790                 795                 800 
Pro Ala Glu Val Thr Leu Ala Met Gln Ser Asn Leu Leu Pro Asn Ala
                805                 810                 815     
His Ala Val Asn Phe Val Asp Val Asn Ser Pro Gly Phe Gly Leu Asp
            820                 825                 830         
Pro Lys Thr Pro Met Glu Met Leu Tyr His His Val His Arg Leu Asn
        835                 840                 845             
Met Ser Gly Pro Phe Gly Gly Ala Val Ser Ala Ala Ser Leu Thr Gln
    850                 855                 860                 
Met Pro Ala Gly Asn Val Phe Thr Thr Ala Glu Gly Leu Phe Ser Thr
865                 870                 875                 880 
Leu Pro Phe Pro Val Tyr Ser Asn Gly Ile His Ala Ala Gln Thr Leu
                885                 890                 895     
Glu Arg Lys Glu Asp
            900     


<210> 1260
<211> 563
<212> PRT
<213> Homo sapiens

<400> 1260
Met Trp Ala Val Leu Arg Leu Ala Leu Arg Pro Cys Ala Arg Ala Ser
 1               5                  10                  15      
Pro Ala Gly Pro Arg Ala Tyr His Gly Asp Ser Val Ala Ser Leu Gly
            20                  25                  30          
Thr Gln Pro Asp Leu Gly Ser Ala Leu Tyr Gln Glu Asn Tyr Lys Gln
        35                  40                  45              
Met Lys Ala Leu Val Asn Gln Leu His Glu Arg Val Glu His Ile Lys
    50                  55                  60                  
Leu Gly Gly Gly Glu Lys Ala Arg Ala Leu His Ile Ser Arg Gly Lys
65                  70                  75                  80  
Leu Leu Pro Arg Glu Arg Ile Asp Asn Leu Ile Asp Pro Gly Ser Pro
                85                  90                  95      
Phe Leu Glu Leu Ser Gln Phe Ala Gly Tyr Gln Leu Tyr Asp Asn Glu
            100                 105                 110         
Glu Val Pro Gly Gly Gly Ile Ile Thr Gly Ile Gly Arg Val Ser Gly
        115                 120                 125             
Val Glu Cys Met Ile Ile Ala Asn Asp Ala Thr Val Lys Gly Gly Ala
    130                 135                 140                 
Tyr Tyr Pro Val Thr Val Lys Lys Gln Leu Arg Ala Gln Glu Ile Ala
145                 150                 155                 160 
Met Gln Asn Arg Leu Pro Cys Ile Tyr Leu Val Asp Ser Gly Gly Ala
                165                 170                 175     
Tyr Leu Pro Arg Gln Ala Asp Val Phe Pro Asp Arg Asp His Phe Gly
            180                 185                 190         
Arg Thr Phe Tyr Asn Gln Ala Ile Met Ser Ser Lys Asn Ile Ala Gln
        195                 200                 205             
Ile Ala Val Val Met Gly Ser Cys Thr Ala Gly Gly Ala Tyr Val Pro
    210                 215                 220                 
Ala Met Ala Asp Glu Asn Ile Ile Val Arg Lys Gln Gly Thr Ile Phe
225                 230                 235                 240 
Leu Ala Gly Pro Pro Leu Val Lys Ala Ala Thr Gly Glu Glu Val Ser
                245                 250                 255     
Ala Glu Asp Leu Gly Gly Ala Asp Leu His Cys Arg Lys Ser Gly Val
            260                 265                 270         
Ser Asp His Trp Ala Leu Asp Asp His His Ala Leu His Leu Thr Arg
        275                 280                 285             
Lys Val Val Arg Asn Leu Asn Tyr Gln Lys Lys Leu Asp Val Thr Ile
    290                 295                 300                 
Glu Pro Ser Glu Glu Pro Leu Phe Pro Ala Asp Glu Leu Tyr Gly Ile
305                 310                 315                 320 
Val Gly Ala Asn Leu Lys Arg Ser Phe Asp Val Arg Glu Val Ile Ala
                325                 330                 335     
Arg Ile Val Asp Gly Ser Arg Phe Thr Glu Phe Lys Ala Phe Tyr Gly
            340                 345                 350         
Asp Thr Leu Val Thr Gly Phe Ala Arg Ile Phe Gly Tyr Pro Val Gly
        355                 360                 365             
Ile Val Gly Asn Asn Gly Val Leu Phe Ser Glu Ser Ala Lys Lys Gly
    370                 375                 380                 
Thr His Phe Val Gln Leu Cys Cys Gln Arg Asn Ile Pro Leu Leu Phe
385                 390                 395                 400 
Leu Gln Asn Ile Thr Gly Phe Met Val Gly Arg Glu Tyr Glu Ala Glu
                405                 410                 415     
Gly Ile Ala Lys Asp Gly Ala Lys Met Val Ala Ala Val Ala Cys Ala
            420                 425                 430         
Gln Val Pro Lys Ile Thr Leu Ile Ile Gly Gly Ser Tyr Gly Ala Gly
        435                 440                 445             
Asn Tyr Gly Met Cys Gly Arg Ala Tyr Ser Pro Arg Phe Leu Tyr Ile
    450                 455                 460                 
Trp Pro Asn Ala Arg Ile Ser Val Met Gly Gly Glu Gln Ala Ala Asn
465                 470                 475                 480 
Val Leu Ala Thr Ile Thr Lys Asp Gln Arg Ala Arg Glu Gly Lys Gln
                485                 490                 495     
Phe Ser Ser Ala Asp Glu Ala Ala Leu Lys Glu Pro Ile Ile Lys Lys
            500                 505                 510         
Phe Glu Glu Glu Gly Asn Pro Tyr Tyr Ser Ser Ala Arg Val Trp Asp
        515                 520                 525             
Asp Gly Ile Ile Asp Pro Ala Asp Thr Arg Leu Val Leu Gly Leu Ser
    530                 535                 540                 
Phe Ser Ala Ala Leu Asn Ala Pro Ile Glu Lys Thr Asp Phe Gly Ile
545                 550                 555                 560 
Phe Arg Met
            


<210> 1261
<211> 366
<212> PRT
<213> Homo sapiens

<400> 1261
Met Ser Ala Asn Ser Ser Arg Val Gly Gln Leu Leu Leu Gln Gly Ser
 1               5                  10                  15      
Ala Cys Ile Arg Trp Lys Gln Asp Val Glu Gly Ala Val Tyr His Leu
            20                  25                  30          
Ala Asn Cys Leu Leu Leu Leu Gly Phe Met Gly Gly Ser Gly Val Tyr
        35                  40                  45              
Gly Cys Phe Tyr Leu Phe Gly Phe Leu Ser Ala Gly Tyr Leu Cys Cys
    50                  55                  60                  
Val Leu Trp Gly Trp Phe Ser Ala Cys Gly Leu Asp Ile Val Leu Trp
65                  70                  75                  80  
Ser Phe Leu Leu Ala Val Val Cys Leu Leu Gln Leu Ala His Leu Val
                85                  90                  95      
Tyr Arg Leu Arg Glu Asp Thr Leu Pro Glu Glu Phe Asp Leu Leu Tyr
            100                 105                 110         
Lys Thr Leu Cys Leu Pro Leu Gln Val Pro Leu Gln Thr Tyr Lys Glu
        115                 120                 125             
Ile Val His Cys Cys Glu Glu Gln Val Leu Thr Leu Ala Thr Glu Gln
    130                 135                 140                 
Thr Tyr Ala Val Glu Gly Glu Thr Pro Ile Asn Arg Leu Ser Leu Leu
145                 150                 155                 160 
Leu Ser Gly Arg Val Arg Val Ser Gln Asp Gly Gln Phe Leu His Tyr
                165                 170                 175     
Ile Phe Pro Tyr Gln Phe Met Asp Ser Pro Glu Trp Glu Ser Leu Gln
            180                 185                 190         
Pro Ser Glu Glu Gly Val Phe Gln Val Thr Leu Thr Ala Glu Thr Ser
        195                 200                 205             
Cys Ser Tyr Ile Ser Trp Pro Arg Lys Ser Leu His Leu Leu Leu Thr
    210                 215                 220                 
Lys Glu Arg Tyr Ile Ser Cys Leu Phe Ser Ala Leu Leu Gly Tyr Asp
225                 230                 235                 240 
Ile Ser Glu Lys Leu Tyr Thr Leu Asn Asp Lys Leu Phe Ala Lys Phe
                245                 250                 255     
Gly Leu Arg Phe Asp Ile Arg Leu Pro Ser Leu Tyr His Val Leu Gly
            260                 265                 270         
Pro Thr Ala Ala Asp Ala Gly Pro Glu Ser Glu Lys Gly Asp Glu Glu
        275                 280                 285             
Val Cys Glu Pro Ala Val Ser Pro Pro Gln Ala Thr Pro Thr Ser Leu
    290                 295                 300                 
Gln Gln Thr Pro Pro Cys Phe Thr Pro Pro Arg Phe Pro Pro Thr Phe
305                 310                 315                 320 
Pro Ala Leu Ser Tyr Arg Gly Gln Val Cys Ser Arg Ala Ser Asn Gly
                325                 330                 335     
Ile Leu Ala Ser Lys Ile Pro Leu Gln Ser Tyr Ser Gln Val Ile Ser
            340                 345                 350         
Arg Gly Gln Ala Pro Leu Ala Pro Thr His Thr Pro Glu Leu
        355                 360                 365     


<210> 1262
<211> 196
<212> PRT
<213> Homo sapiens

<400> 1262
Met Glu Ile Ile Ser Ser Lys Leu Phe Ile Leu Leu Thr Leu Ala Thr
 1               5                  10                  15      
Ser Ser Leu Leu Thr Ser Asn Ile Phe Cys Ala Asp Glu Leu Val Met
            20                  25                  30          
Ser Asn Leu His Ser Lys Glu Asn Tyr Asp Lys Tyr Ser Glu Pro Arg
        35                  40                  45              
Gly Tyr Pro Lys Gly Glu Arg Ser Leu Asn Phe Glu Glu Leu Lys Asp
    50                  55                  60                  
Trp Gly Pro Lys Asn Val Ile Lys Met Ser Thr Pro Ala Val Asn Lys
65                  70                  75                  80  
Met Pro His Ser Phe Ala Asn Leu Pro Leu Arg Phe Gly Arg Asn Val
                85                  90                  95      
Gln Glu Glu Arg Ser Ala Gly Ala Thr Ala Asn Leu Pro Leu Arg Ser
            100                 105                 110         
Gly Arg Asn Met Glu Val Ser Leu Val Arg Arg Val Pro Asn Leu Pro
        115                 120                 125             
Gln Arg Phe Gly Arg Thr Thr Thr Ala Lys Ser Val Cys Arg Met Leu
    130                 135                 140                 
Ser Asp Leu Cys Gln Gly Ser Met His Ser Pro Cys Ala Asn Asp Leu
145                 150                 155                 160 
Phe Tyr Ser Met Thr Cys Gln His Gln Glu Ile Gln Asn Pro Asp Gln
                165                 170                 175     
Lys Gln Ser Arg Arg Leu Leu Phe Lys Lys Ile Asp Asp Ala Glu Leu
            180                 185                 190         
Lys Gln Glu Lys
        195     


<210> 1263
<211> 128
<212> PRT
<213> Homo sapiens

<400> 1263
Met Ala Ala Phe Met Leu Gly Ser Leu Leu Arg Thr Phe Lys Gln Met
 1               5                  10                  15      
Val Pro Ser Ser Ala Ser Gly Gln Val Arg Ser His Tyr Val Asp Trp
            20                  25                  30          
Arg Met Trp Arg Asp Val Lys Arg Arg Lys Met Ala Tyr Glu Tyr Ala
        35                  40                  45              
Asp Glu Arg Leu Arg Ile Asn Ser Leu Arg Lys Asn Thr Ile Leu Pro
    50                  55                  60                  
Lys Ile Leu Gln Asp Val Ala Asp Glu Glu Ile Ala Ala Leu Pro Arg
65                  70                  75                  80  
Asp Ser Cys Pro Val Arg Ile Arg Asn Arg Cys Val Met Thr Ser Arg
                85                  90                  95      
Pro Arg Gly Val Lys Arg Arg Trp Arg Leu Ser Arg Ile Val Phe Arg
            100                 105                 110         
His Leu Ala Asp His Gly Gln Leu Ser Gly Ile Gln Arg Ala Thr Trp
        115                 120                 125             


<210> 1264
<211> 131
<212> PRT
<213> Homo sapiens

<400> 1264
Lys Asp Thr Pro Arg Leu Ser Leu Leu Leu Val Ile Leu Gly Val Ile
 1               5                  10                  15      
Phe Met Asn Gly Asn Arg Ala Ser Glu Ala Val Leu Trp Glu Ala Leu
            20                  25                  30          
Arg Lys Met Gly Leu Arg Pro Gly Val Arg His Pro Phe Leu Gly Asp
        35                  40                  45              
Leu Arg Lys Leu Ile Thr Asp Asp Phe Val Lys Gln Lys Tyr Leu Glu
    50                  55                  60                  
Tyr Lys Lys Ile Pro Asn Ser Asn Pro Pro Glu Tyr Glu Phe Leu Trp
65                  70                  75                  80  
Gly Leu Arg Ala Arg His Glu Thr Ser Lys Met Arg Val Leu Arg Phe
                85                  90                  95      
Ile Ala Gln Asn Gln Asn Arg Asp Pro Arg Glu Trp Lys Ala His Phe
            100                 105                 110         
Leu Glu Ala Val Asp Asp Ala Phe Lys Thr Met Asp Val Asp Met Ala
        115                 120                 125             
Glu Glu His
    130     


<210> 1265
<211> 175
<212> PRT
<213> Homo sapiens

<400> 1265
Met Arg Leu Ser Val Ala Ala Ala Ile Ser His Gly Arg Val Phe Arg
 1               5                  10                  15      
Arg Met Gly Leu Gly Pro Glu Ser Arg Ile His Leu Leu Arg Asn Leu
            20                  25                  30          
Leu Thr Gly Leu Val Arg His Glu Arg Ile Glu Ala Pro Trp Ala Arg
        35                  40                  45              
Val Asp Glu Met Arg Gly Tyr Ala Glu Lys Leu Ile Asp Tyr Gly Lys
    50                  55                  60                  
Leu Gly Asp Thr Asn Glu Arg Ala Met Arg Met Ala Asp Phe Trp Leu
65                  70                  75                  80  
Thr Glu Lys Asp Leu Ile Pro Lys Leu Phe Gln Val Leu Ala Pro Arg
                85                  90                  95      
Tyr Lys Asp Gln Thr Gly Gly Tyr Thr Arg Met Leu Gln Ile Pro Asn
            100                 105                 110         
Arg Ser Leu Asp Arg Ala Lys Met Ala Val Ile Glu Tyr Lys Gly Asn
        115                 120                 125             
Cys Leu Pro Pro Leu Pro Leu Pro Arg Arg Asp Ser His Leu Thr Leu
    130                 135                 140                 
Leu Asn Gln Leu Leu Gln Gly Leu Arg Gln Asp Leu Arg Gln Ser Gln
145                 150                 155                 160 
Glu Ala Ser Asn His Ser Ser His Thr Ala Gln Thr Pro Gly Ile
                165                 170                 175 


<210> 1266
<211> 586
<212> PRT
<213> Homo sapiens

<400> 1266
Met Phe Ala Val Val Phe Phe Ile Leu Ser Leu Met Thr Cys Gln Pro
 1               5                  10                  15      
Gly Val Thr Ala Gln Glu Lys Val Asn Gln Arg Val Arg Arg Ala Ala
            20                  25                  30          
Thr Pro Ala Ala Val Thr Cys Gln Leu Ser Asn Trp Ser Glu Trp Thr
        35                  40                  45              
Asp Cys Phe Pro Cys Gln Asp Lys Lys Tyr Arg His Arg Ser Leu Leu
    50                  55                  60                  
Gln Pro Asn Lys Phe Gly Gly Thr Ile Cys Ser Gly Asp Ile Trp Asp
65                  70                  75                  80  
Gln Ala Ser Cys Ser Ser Ser Thr Thr Cys Val Arg Gln Ala Gln Cys
                85                  90                  95      
Gly Gln Asp Phe Gln Cys Lys Glu Thr Gly Arg Cys Leu Lys Arg His
            100                 105                 110         
Leu Val Cys Asn Gly Asp Gln Asp Cys Leu Asp Gly Ser Asp Glu Asp
        115                 120                 125             
Asp Cys Glu Asp Val Arg Ala Ile Asp Glu Asp Cys Ser Gln Tyr Glu
    130                 135                 140                 
Pro Ile Pro Gly Ser Gln Lys Ala Ala Leu Gly Tyr Asn Ile Leu Thr
145                 150                 155                 160 
Gln Glu Asp Ala Gln Ser Val Tyr Asp Ala Ser Tyr Tyr Gly Gly Gln
                165                 170                 175     
Cys Glu Thr Val Tyr Asn Gly Glu Trp Arg Glu Leu Arg Tyr Asp Ser
            180                 185                 190         
Thr Cys Glu Arg Leu Tyr Tyr Gly Asp Asp Glu Lys Tyr Phe Arg Lys
        195                 200                 205             
Pro Tyr Asn Phe Leu Lys Tyr His Phe Glu Ala Leu Ala Asp Thr Gly
    210                 215                 220                 
Ile Ser Ser Glu Phe Tyr Asp Asn Ala Asn Asp Leu Leu Ser Lys Val
225                 230                 235                 240 
Lys Lys Asp Lys Ser Asp Ser Phe Gly Val Thr Ile Gly Ile Gly Pro
                245                 250                 255     
Ala Gly Ser Pro Leu Leu Lys Phe Ile Phe Thr Arg Ile Phe Thr Lys
            260                 265                 270         
Val Gln Thr Ala His Phe Lys Met Arg Lys Asp Asp Ile Met Leu Asp
        275                 280                 285             
Glu Gly Met Leu Gln Ser Leu Met Glu Leu Pro Asp Gln Tyr Asn Tyr
    290                 295                 300                 
Gly Met Tyr Ala Lys Phe Ile Asn Asp Tyr Gly Thr His Tyr Ile Thr
305                 310                 315                 320 
Ser Gly Ser Met Gly Gly Ile Tyr Glu Tyr Ile Leu Val Ile Asp Lys
                325                 330                 335     
Ala Lys Met Glu Ser Leu Gly Ile Thr Ser Arg Asp Ile Thr Thr Cys
            340                 345                 350         
Phe Gly Gly Ser Leu Gly Ile Gln Tyr Glu Asp Lys Ile Asn Val Gly
        355                 360                 365             
Gly Gly Leu Ser Gly Asp His Cys Lys Lys Phe Gly Glu Arg Ala Arg
    370                 375                 380                 
Lys Ala Met Ala Val Glu Asp Ile Ile Ser Arg Val Arg Gly Gly Ser
385                 390                 395                 400 
Ser Gly Trp Ser Gly Gly Leu Ala Gln Asn Arg Ser Thr Ile Thr Tyr
                405                 410                 415     
Arg Ser Trp Gly Arg Ser Leu Lys Tyr Asn Pro Val Val Ile Asp Phe
            420                 425                 430         
Glu Met Gln Pro Ile His Glu Val Leu Arg His Thr Ser Leu Gly Pro
        435                 440                 445             
Leu Glu Ala Lys Arg Gln Asn Leu Arg Arg Ala Leu Asp Gln Tyr Leu
    450                 455                 460                 
Met Glu Phe Asn Ala Cys Arg Cys Gly Pro Cys Phe Asn Asn Gly Val
465                 470                 475                 480 
Pro Ile Leu Glu Gly Thr Ser Cys Arg Cys Gln Cys Arg Leu Gly Ser
                485                 490                 495     
Leu Gly Ala Ala Cys Glu Gln Thr Gln Thr Glu Gly Lys Glu Pro Lys
            500                 505                 510         
Gln Met Gly Ala Gly Val Ala Gly Ala Pro Gly Leu Tyr Ala Glu Gln
        515                 520                 525             
Ala Ser Arg Lys Gly Glu Glu Ser Val Thr Ile Gln His Leu Arg Met
    530                 535                 540                 
Glu Gly Pro Arg Val Gln Gly Gly Lys Tyr Arg Arg Arg Leu Ala Glu
545                 550                 555                 560 
Gly Leu Trp Thr Gln Ala Gly Pro Asp Ala Val Asp Val Asp Pro Cys
                565                 570                 575     
Thr Asp Tyr Trp Ile Lys Thr Ser Phe Asn
            580                 585     


<210> 1267
<211> 4370
<212> PRT
<213> Homo sapiens

<400> 1267
Val Thr His Gly Leu Arg Ala Tyr Asp Gly Leu Ser Leu Pro Glu Asp
 1               5                  10                  15      
Ile Glu Thr Val Thr Ala Ser Gln Met Arg Trp Thr His Ser Tyr Leu
            20                  25                  30          
Ser Asp Asp Glu Asp Met Leu Ala Asp Ser Ile Ser Gly Asp Asp Leu
        35                  40                  45              
Gly Ser Gly Asp Leu Gly Ser Gly Asp Phe Gln Met Val Tyr Phe Arg
    50                  55                  60                  
Ala Leu Val Asn Phe Thr Arg Ser Ile Glu Tyr Ser Pro Gln Leu Glu
65                  70                  75                  80  
Asp Ala Gly Ser Arg Glu Phe Arg Glu Val Ser Glu Ala Val Val Asp
                85                  90                  95      
Thr Leu Glu Ser Glu Tyr Leu Lys Ile Pro Gly Asp Gln Val Val Ser
            100                 105                 110         
Val Val Phe Ile Lys Glu Leu Asp Gly Trp Val Phe Val Glu Leu Asp
        115                 120                 125             
Val Gly Ser Glu Gly Asn Ala Asp Gly Ala Gln Ile Gln Glu Met Leu
    130                 135                 140                 
Leu Arg Val Ile Ser Ser Gly Ser Val Ala Ser Tyr Val Thr Ser Pro
145                 150                 155                 160 
Gln Gly Phe Gln Phe Arg Arg Leu Gly Thr Val Pro Gln Phe Pro Arg
                165                 170                 175     
Ala Cys Thr Glu Ala Glu Phe Ala Cys His Ser Tyr Asn Glu Cys Val
            180                 185                 190         
Ala Leu Glu Tyr Arg Cys Asp Arg Arg Pro Asp Cys Arg Asp Met Ser
        195                 200                 205             
Asp Glu Leu Asn Cys Glu Glu Pro Val Leu Gly Ile Ser Pro Thr Phe
    210                 215                 220                 
Ser Leu Leu Val Glu Thr Thr Ser Leu Pro Pro Arg Pro Glu Thr Thr
225                 230                 235                 240 
Ile Met Arg Gln Pro Pro Val Thr His Ala Pro Gln Pro Leu Leu Pro
                245                 250                 255     
Gly Ser Val Arg Pro Leu Pro Cys Gly Pro Gln Glu Ala Ala Cys Arg
            260                 265                 270         
Asn Gly His Cys Ile Pro Arg Asp Tyr Leu Cys Asp Gly Gln Glu Asp
        275                 280                 285             
Cys Glu Asp Gly Ser Asp Glu Leu Asp Cys Gly Pro Pro Pro Pro Cys
    290                 295                 300                 
Glu Pro Asn Glu Phe Pro Cys Gly Asn Gly His Cys Ala Leu Lys Leu
305                 310                 315                 320 
Trp Arg Cys Asp Gly Asp Phe Asp Cys Glu Asp Arg Thr Asp Glu Ala
                325                 330                 335     
Asn Cys Pro Thr Lys Arg Pro Glu Glu Val Cys Gly Pro Thr Gln Phe
            340                 345                 350         
Arg Cys Val Ser Thr Asn Met Cys Ile Pro Ala Ser Phe His Cys Asp
        355                 360                 365             
Glu Glu Ser Asp Cys Pro Asp Arg Ser Asp Glu Phe Gly Cys Met Pro
    370                 375                 380                 
Pro Gln Val Val Thr Pro Pro Arg Glu Ser Ile Gln Ala Ser Arg Gly
385                 390                 395                 400 
Gln Thr Val Thr Phe Thr Cys Val Ala Ile Gly Val Pro Thr Pro Ile
                405                 410                 415     
Ile Asn Trp Arg Leu Asn Trp Gly His Ile Pro Ser His Pro Arg Val
            420                 425                 430         
Thr Val Thr Ser Glu Gly Gly Arg Gly Thr Leu Ile Ile Arg Asp Val
        435                 440                 445             
Lys Glu Ser Asp Gln Gly Ala Tyr Thr Cys Glu Ala Met Asn Ala Arg
    450                 455                 460                 
Gly Met Val Phe Gly Ile Pro Asp Gly Val Leu Glu Leu Val Pro Gln
465                 470                 475                 480 
Arg Gly Pro Cys Pro Asp Gly His Phe Tyr Leu Glu His Ser Ala Ala
                485                 490                 495     
Cys Leu Pro Cys Phe Cys Phe Gly Ile Thr Ser Val Cys Gln Ser Thr
            500                 505                 510         
Arg Arg Phe Arg Asp Gln Ile Arg Leu Arg Phe Asp Gln Pro Asp Asp
        515                 520                 525             
Phe Lys Gly Val Asn Val Thr Met Pro Ala Gln Pro Gly Thr Pro Pro
    530                 535                 540                 
Leu Ser Ser Thr Gln Leu Gln Ile Asp Pro Ser Leu His Glu Phe Gln
545                 550                 555                 560 
Leu Val Asp Leu Ser Arg Arg Phe Leu Val His Asp Ser Phe Trp Ala
                565                 570                 575     
Leu Pro Glu Gln Phe Leu Gly Asn Lys Val Asp Ser Tyr Gly Gly Ser
            580                 585                 590         
Leu Arg Tyr Asn Val Arg Tyr Glu Leu Ala Arg Gly Met Leu Glu Pro
        595                 600                 605             
Val Gln Arg Pro Asp Val Val Leu Val Gly Ala Gly Tyr Arg Leu Leu
    610                 615                 620                 
Ser Arg Gly His Thr Pro Thr Gln Pro Gly Ala Leu Asn Gln Arg Gln
625                 630                 635                 640 
Val Gln Phe Ser Glu Glu His Trp Val His Glu Ser Gly Arg Pro Val
                645                 650                 655     
Gln Arg Ala Glu Leu Leu Gln Val Leu Gln Ser Leu Glu Ala Val Leu
            660                 665                 670         
Ile Gln Thr Val Tyr Asn Thr Lys Met Ala Ser Val Gly Leu Ser Asp
        675                 680                 685             
Ile Ala Met Asp Thr Thr Val Thr His Ala Thr Ser His Gly Arg Ala
    690                 695                 700                 
His Ser Val Glu Glu Cys Arg Cys Pro Ile Gly Tyr Ser Gly Leu Ser
705                 710                 715                 720 
Cys Glu Ser Cys Asp Ala His Phe Thr Arg Val Pro Gly Gly Pro Tyr
                725                 730                 735     
Leu Gly Thr Cys Ser Gly Cys Ser Cys Asn Gly His Ala Ser Ser Cys
            740                 745                 750         
Asp Pro Val Tyr Gly His Cys Leu Asn Cys Gln His Asn Thr Glu Gly
        755                 760                 765             
Pro Gln Cys Asn Lys Cys Lys Ala Gly Phe Phe Gly Asp Ala Met Lys
    770                 775                 780                 
Ala Thr Ala Thr Ser Cys Arg Pro Cys Pro Cys Pro Tyr Ile Asp Ala
785                 790                 795                 800 
Ser Arg Arg Phe Ser Asp Thr Cys Phe Leu Asp Thr Asp Gly Gln Ala
                805                 810                 815     
Thr Cys Asp Ala Cys Ala Pro Gly Tyr Thr Gly Arg Arg Cys Glu Ser
            820                 825                 830         
Cys Ala Pro Gly Tyr Glu Gly Asn Pro Ile Gln Pro Gly Gly Lys Cys
        835                 840                 845             
Arg Pro Val Asn Gln Glu Ile Val Arg Cys Asp Glu Arg Gly Ser Met
    850                 855                 860                 
Gly Thr Ser Gly Glu Ala Cys Arg Cys Lys Asn Asn Val Val Gly Arg
865                 870                 875                 880 
Leu Cys Asn Glu Cys Ala Asp Gly Ser Phe His Leu Ser Thr Arg Asn
                885                 890                 895     
Pro Asp Gly Cys Leu Lys Cys Phe Cys Met Gly Val Ser Arg His Cys
            900                 905                 910         
Thr Ser Ser Ser Trp Ser Arg Ala Gln Leu His Gly Ala Ser Glu Glu
        915                 920                 925             
Pro Gly His Phe Ser Leu Thr Asn Ala Ala Ser Thr His Thr Thr Asn
    930                 935                 940                 
Glu Gly Ile Phe Ser Pro Thr Pro Gly Glu Leu Gly Phe Ser Ser Phe
945                 950                 955                 960 
His Arg Leu Leu Ser Gly Pro Tyr Phe Trp Ser Leu Pro Ser Arg Phe
                965                 970                 975     
Leu Gly Asp Lys Val Thr Ser Tyr Gly Gly Glu Leu Arg Phe Thr Val
            980                 985                 990         
Thr Gln Arg Ser Gln Pro Gly Ser Thr Pro Leu His Gly Gln Pro Leu
        995                 1000                1005            
Val Val Leu Gln Gly Asn Asn Ile Ile Leu Glu His His Val Ala Gln
    1010                1015                1020                
Glu Pro Ser Pro Gly Gln Pro Ser Thr Phe Ile Val Pro Phe Arg Glu
1025                1030                1035                1040
Gln Ala Trp Gln Arg Pro Asp Gly Gln Pro Ala Thr Arg Glu His Leu
                1045                1050                1055    
Leu Met Ala Leu Ala Gly Ile Asp Thr Leu Leu Ile Arg Ala Ser Tyr
            1060                1065                1070        
Ala Gln Gln Pro Ala Glu Ser Arg Val Ser Gly Ile Ser Met Asp Val
        1075                1080                1085            
Ala Val Pro Glu Glu Thr Gly Gln Asp Pro Ala Leu Glu Val Glu Gln
    1090                1095                1100                
Cys Ser Cys Pro Pro Gly Tyr Arg Gly Pro Ser Cys Gln Asp Cys Asp
1105                1110                1115                1120
Thr Gly Tyr Thr Arg Thr Pro Ser Gly Leu Tyr Leu Gly Thr Cys Glu
                1125                1130                1135    
Arg Cys Ser Cys His Gly His Ser Glu Ala Cys Glu Pro Glu Thr Gly
            1140                1145                1150        
Ala Cys Gln Gly Cys Gln His His Thr Glu Gly Pro Arg Cys Glu Gln
        1155                1160                1165            
Cys Gln Pro Gly Tyr Tyr Gly Asp Ala Gln Arg Gly Thr Pro Gln Asp
    1170                1175                1180                
Cys Gln Leu Cys Pro Cys Tyr Gly Asp Pro Ala Ala Gly Gln Ala Ala
1185                1190                1195                1200
His Thr Cys Phe Leu Asp Thr Asp Gly His Pro Thr Cys Asp Ala Cys
                1205                1210                1215    
Ser Pro Gly His Ser Gly Arg His Cys Glu Arg Cys Ala Pro Gly Tyr
            1220                1225                1230        
Tyr Gly Asn Pro Ser Gln Gly Gln Pro Cys Gln Arg Asp Ser Gln Val
        1235                1240                1245            
Pro Gly Pro Ile Gly Cys Asn Cys Asp Pro Gln Gly Ser Val Ser Ser
    1250                1255                1260                
Gln Cys Asp Ala Ala Gly Gln Cys Gln Cys Lys Ala Gln Val Glu Gly
1265                1270                1275                1280
Leu Thr Cys Ser His Cys Arg Pro His His Phe His Leu Ser Ala Ser
                1285                1290                1295    
Asn Pro Asp Gly Cys Leu Pro Cys Phe Cys Met Gly Ile Thr Gln Gln
            1300                1305                1310        
Cys Ala Ser Ser Ala Tyr Thr Arg His Leu Ile Ser Thr His Phe Ala
        1315                1320                1325            
Pro Gly Asp Phe Gln Gly Phe Ala Leu Val Asn Pro Gln Arg Asn Ser
    1330                1335                1340                
Arg Leu Thr Gly Glu Phe Thr Val Glu Pro Val Pro Glu Gly Ala Gln
1345                1350                1355                1360
Leu Ser Phe Gly Asn Phe Ala Gln Leu Gly His Glu Ser Phe Tyr Trp
                1365                1370                1375    
Gln Leu Pro Glu Thr Tyr Gln Gly Asp Lys Val Ala Ala Tyr Gly Gly
            1380                1385                1390        
Lys Leu Arg Tyr Thr Leu Ser Tyr Thr Ala Gly Pro Gln Gly Ser Pro
        1395                1400                1405            
Leu Ser Asp Pro Asp Val Gln Ile Thr Gly Asn Asn Ile Met Leu Val
    1410                1415                1420                
Ala Ser Gln Pro Ala Leu Gln Gly Pro Glu Arg Arg Ser Tyr Glu Ile
1425                1430                1435                1440
Met Phe Arg Glu Glu Phe Trp Arg Arg Pro Asp Gly Gln Pro Ala Thr
                1445                1450                1455    
Arg Glu His Leu Leu Met Ala Leu Ala Asp Leu Asp Glu Leu Leu Ile
            1460                1465                1470        
Arg Ala Thr Phe Ser Ser Val Pro Leu Val Ala Ser Ile Ser Ala Val
        1475                1480                1485            
Ser Leu Glu Val Ala Gln Pro Gly Pro Ser Asn Arg Pro Arg Ala Leu
    1490                1495                1500                
Glu Val Glu Glu Cys Arg Cys Pro Pro Gly Tyr Ile Gly Leu Ser Cys
1505                1510                1515                1520
Gln Asp Cys Ala Pro Gly Tyr Thr Arg Thr Gly Ser Gly Leu Tyr Leu
                1525                1530                1535    
Gly His Cys Glu Leu Cys Glu Cys Asn Gly His Ser Asp Leu Cys His
            1540                1545                1550        
Pro Glu Thr Gly Ala Cys Ser Gln Cys Gln His Asn Ala Ala Gly Glu
        1555                1560                1565            
Phe Cys Glu Leu Cys Ala Pro Gly Tyr Tyr Gly Asp Ala Thr Ala Gly
    1570                1575                1580                
Thr Pro Glu Asp Cys Gln Pro Cys Ala Cys Pro Leu Thr Asn Pro Glu
1585                1590                1595                1600
Asn Met Phe Ser Arg Thr Cys Glu Ser Leu Gly Ala Gly Gly Tyr Arg
                1605                1610                1615    
Cys Thr Ala Cys Glu Pro Gly Tyr Thr Gly Gln Tyr Cys Glu Gln Cys
            1620                1625                1630        
Gly Pro Gly Tyr Val Gly Asn Pro Ser Val Gln Gly Gly Gln Cys Leu
        1635                1640                1645            
Pro Glu Thr Asn Gln Ala Pro Leu Val Val Glu Val His Pro Ala Arg
    1650                1655                1660                
Ser Ile Val Pro Gln Gly Gly Ser His Ser Leu Arg Cys Gln Val Ser
1665                1670                1675                1680
Gly Ser Pro Pro His Tyr Phe Tyr Trp Ser Arg Glu Asp Gly Arg Pro
                1685                1690                1695    
Val Pro Ser Gly Thr Gln Gln Arg His Gln Gly Ser Glu Leu His Phe
            1700                1705                1710        
Pro Ser Val Gln Pro Ser Asp Ala Gly Val Tyr Ile Cys Thr Cys Arg
        1715                1720                1725            
Asn Leu His Gln Ser Asn Thr Ser Arg Ala Glu Leu Leu Val Thr Glu
    1730                1735                1740                
Ala Pro Ser Lys Pro Ile Thr Val Thr Val Glu Glu Gln Arg Ser Gln
1745                1750                1755                1760
Ser Val Arg Pro Gly Ala Asp Val Thr Phe Ile Cys Thr Ala Lys Ser
                1765                1770                1775    
Lys Ser Pro Ala Tyr Thr Leu Val Trp Thr Arg Leu His Asn Gly Lys
            1780                1785                1790        
Leu Pro Thr Arg Ala Met Asp Phe Asn Gly Ile Leu Thr Ile Arg Asn
        1795                1800                1805            
Val Gln Leu Ser Asp Ala Gly Thr Tyr Val Cys Thr Gly Ser Asn Met
    1810                1815                1820                
Phe Ala Met Asp Gln Gly Thr Ala Thr Leu His Val Gln Ala Ser Gly
1825                1830                1835                1840
Thr Leu Ser Ala Pro Val Val Ser Ile His Pro Pro Gln Leu Thr Val
                1845                1850                1855    
Gln Pro Gly Gln Leu Ala Glu Phe Arg Cys Ser Ala Thr Gly Ser Pro
            1860                1865                1870        
Thr Pro Thr Leu Glu Trp Thr Gly Gly Pro Gly Gly Gln Leu Pro Ala
        1875                1880                1885            
Lys Ala Gln Ile His Gly Gly Ile Leu Arg Leu Pro Ala Val Glu Pro
    1890                1895                1900                
Thr Asp Gln Ala Gln Tyr Leu Cys Arg Ala His Ser Ser Ala Gly Gln
1905                1910                1915                1920
Gln Val Ala Arg Ala Val Leu His Val His Gly Gly Gly Gly Pro Arg
                1925                1930                1935    
Val Gln Val Ser Pro Glu Arg Thr Gln Val His Ala Gly Arg Thr Val
            1940                1945                1950        
Arg Leu Tyr Cys Arg Ala Ala Gly Val Pro Ser Ala Thr Ile Thr Trp
        1955                1960                1965            
Arg Lys Glu Gly Gly Ser Leu Pro Pro Gln Ala Arg Ser Glu Arg Thr
    1970                1975                1980                
Asp Ile Ala Thr Leu Leu Ile Pro Ala Ile Thr Thr Ala Asp Ala Gly
1985                1990                1995                2000
Phe Tyr Leu Cys Val Ala Thr Ser Pro Ala Gly Thr Ala Gln Ala Arg
                2005                2010                2015    
Ile Gln Val Val Val Leu Ser Ala Ser Asp Ala Ser Pro Pro Pro Val
            2020                2025                2030        
Lys Ile Glu Ser Ser Ser Pro Ser Val Thr Glu Gly Gln Thr Leu Asp
        2035                2040                2045            
Leu Asn Cys Val Val Ala Gly Ser Ala His Ala Gln Val Thr Trp Tyr
    2050                2055                2060                
Arg Arg Gly Gly Ser Leu Pro Pro His Thr Gln Val His Gly Ser Arg
2065                2070                2075                2080
Leu Arg Leu Pro Gln Val Ser Pro Ala Asp Ser Gly Glu Tyr Val Cys
                2085                2090                2095    
Arg Val Glu Asn Gly Ser Gly Pro Lys Glu Ala Ser Ile Thr Val Ser
            2100                2105                2110        
Val Leu His Gly Thr His Ser Gly Pro Ser Tyr Thr Pro Val Pro Gly
        2115                2120                2125            
Ser Thr Arg Pro Ile Arg Ile Glu Pro Ser Ser Ser His Val Ala Glu
    2130                2135                2140                
Gly Gln Thr Leu Asp Leu Asn Cys Val Val Pro Gly Gln Ala His Ala
2145                2150                2155                2160
Gln Val Thr Trp His Lys Arg Gly Gly Ser Leu Pro Ala Arg His Gln
                2165                2170                2175    
Thr His Gly Ser Leu Leu Arg Leu His Gln Val Thr Pro Ala Asp Ser
            2180                2185                2190        
Gly Glu Tyr Val Cys His Val Val Gly Thr Ser Gly Pro Leu Glu Ala
        2195                2200                2205            
Ser Val Leu Val Thr Ile Glu Ala Ser Val Ile Pro Gly Pro Ile Pro
    2210                2215                2220                
Pro Val Arg Ile Glu Ser Ser Ser Ser Thr Val Ala Glu Gly Gln Thr
2225                2230                2235                2240
Leu Asp Leu Ser Cys Val Val Ala Gly Gln Ala His Ala Gln Val Thr
                2245                2250                2255    
Trp Tyr Lys Arg Gly Gly Ser Leu Pro Ala Arg His Gln Val Arg Gly
            2260                2265                2270        
Ser Arg Leu Tyr Ile Phe Gln Ala Ser Pro Ala Asp Ala Gly Gln Tyr
        2275                2280                2285            
Val Cys Arg Ala Ser Asn Gly Met Glu Ala Ser Ile Thr Val Thr Val
    2290                2295                2300                
Thr Gly Thr Gln Gly Ala Asn Leu Ala Tyr Pro Ala Gly Ser Thr Gln
2305                2310                2315                2320
Pro Ile Arg Ile Glu Pro Ser Ser Ser Gln Val Ala Glu Gly Gln Thr
                2325                2330                2335    
Leu Asp Leu Asn Cys Val Val Pro Gly Gln Ser His Ala Gln Val Thr
            2340                2345                2350        
Trp His Lys Arg Gly Gly Ser Leu Pro Val Arg His Gln Thr His Gly
        2355                2360                2365            
Ser Leu Leu Arg Leu Tyr Gln Ala Ser Pro Ala Asp Ser Gly Glu Tyr
    2370                2375                2380                
Val Cys Arg Val Leu Gly Ser Ser Val Pro Leu Glu Ala Ser Val Leu
2385                2390                2395                2400
Val Thr Ile Glu Pro Ala Gly Ser Val Pro Ala Leu Gly Val Thr Pro
                2405                2410                2415    
Thr Val Arg Ile Glu Ser Ser Ser Ser Gln Val Ala Glu Gly Gln Thr
            2420                2425                2430        
Leu Asp Leu Asn Cys Leu Val Ala Gly Gln Ala His Ala Gln Val Thr
        2435                2440                2445            
Trp His Lys Arg Gly Gly Ser Leu Pro Ala Arg His Gln Val His Gly
    2450                2455                2460                
Ser Arg Leu Arg Leu Leu Gln Val Thr Pro Ala Asp Ser Gly Glu Tyr
2465                2470                2475                2480
Val Cys Arg Val Val Gly Ser Ser Gly Thr Gln Glu Ala Ser Val Leu
                2485                2490                2495    
Val Thr Ile Gln Gln Arg Leu Ser Gly Ser His Ser Gln Gly Val Ala
            2500                2505                2510        
Tyr Pro Val Arg Ile Glu Ser Ser Ser Ala Ser Leu Ala Asn Gly His
        2515                2520                2525            
Thr Leu Asp Leu Asn Cys Leu Val Ala Ser Gln Ala Pro His Thr Ile
    2530                2535                2540                
Thr Trp Tyr Lys Arg Gly Gly Ser Leu Pro Ser Arg His Gln Ile Val
2545                2550                2555                2560
Gly Ser Arg Leu Arg Ile Pro Gln Val Thr Pro Ala Asp Ser Gly Glu
                2565                2570                2575    
Tyr Val Cys His Val Ser Asn Gly Ala Gly Ser Arg Glu Thr Ser Leu
            2580                2585                2590        
Ile Val Thr Ile Gln Gly Ser Gly Ser Ser His Val Pro Ser Val Ser
        2595                2600                2605            
Pro Pro Ile Arg Ile Glu Ser Ser Ser Pro Thr Val Val Glu Gly Gln
    2610                2615                2620                
Thr Leu Asp Leu Asn Cys Val Val Ala Arg Gln Pro Gln Ala Ile Ile
2625                2630                2635                2640
Thr Trp Tyr Lys Arg Gly Gly Ser Leu Pro Ser Arg His Gln Thr His
                2645                2650                2655    
Gly Ser His Leu Arg Leu His Gln Met Ser Val Ala Asp Ser Gly Glu
            2660                2665                2670        
Tyr Val Cys Arg Ala Asn Asn Asn Ile Asp Ala Leu Glu Ala Ser Ile
        2675                2680                2685            
Val Ile Ser Val Ser Pro Ser Ala Gly Ser Pro Ser Ala Pro Gly Ser
    2690                2695                2700                
Ser Met Pro Ile Arg Ile Glu Ser Ser Ser Ser His Val Ala Glu Gly
2705                2710                2715                2720
Glu Thr Leu Asp Leu Asn Cys Val Val Pro Gly Gln Ala His Ala Gln
                2725                2730                2735    
Val Thr Trp His Lys Arg Gly Gly Ser Leu Pro Ser His His Gln Thr
            2740                2745                2750        
Arg Gly Ser Arg Leu Arg Leu His His Val Ser Pro Ala Asp Ser Gly
        2755                2760                2765            
Glu Tyr Val Cys Arg Val Met Gly Ser Ser Gly Pro Leu Glu Ala Ser
    2770                2775                2780                
Val Leu Val Thr Ile Glu Ala Ser Gly Ser Ser Ala Val His Val Pro
2785                2790                2795                2800
Ala Pro Gly Gly Ala Pro Pro Ile Arg Ile Glu Pro Ser Ser Ser Arg
                2805                2810                2815    
Val Ala Glu Gly Gln Thr Leu Asp Leu Lys Cys Val Val Pro Gly Gln
            2820                2825                2830        
Ala His Ala Gln Val Thr Trp His Lys Arg Gly Gly Asn Leu Pro Ala
        2835                2840                2845            
Arg His Gln Val His Gly Pro Leu Leu Arg Leu Asn Gln Val Ser Pro
    2850                2855                2860                
Ala Asp Ser Gly Glu Tyr Ser Cys Gln Val Thr Gly Ser Ser Gly Thr
2865                2870                2875                2880
Leu Glu Ala Ser Val Leu Val Thr Ile Glu Pro Ser Ser Pro Gly Pro
                2885                2890                2895    
Ile Pro Ala Pro Gly Leu Ala Gln Pro Ile Tyr Ile Glu Ala Ser Ser
            2900                2905                2910        
Ser His Val Thr Glu Gly Gln Thr Leu Asp Leu Asn Cys Val Val Pro
        2915                2920                2925            
Gly Gln Ala His Ala Gln Val Thr Trp Tyr Lys Arg Gly Gly Ser Leu
    2930                2935                2940                
Pro Ala Arg His Gln Thr His Gly Ser Gln Leu Arg Leu His Leu Val
2945                2950                2955                2960
Ser Pro Ala Asp Ser Gly Glu Tyr Val Cys Arg Ala Ala Ser Gly Pro
                2965                2970                2975    
Gly Pro Glu Gln Glu Ala Ser Phe Thr Val Thr Val Pro Pro Ser Glu
            2980                2985                2990        
Gly Ser Ser Tyr Arg Leu Arg Ser Pro Val Ile Ser Ile Asp Pro Pro
        2995                3000                3005            
Ser Ser Thr Val Gln Gln Gly Gln Asp Ala Ser Phe Lys Cys Leu Ile
    3010                3015                3020                
His Asp Gly Ala Ala Pro Ile Ser Leu Glu Trp Lys Thr Arg Asn Gln
3025                3030                3035                3040
Glu Leu Glu Asp Asn Val His Ile Ser Pro Asn Gly Ser Ile Ile Thr
                3045                3050                3055    
Ile Val Gly Thr Arg Pro Ser Asn His Gly Thr Tyr Arg Cys Val Ala
            3060                3065                3070        
Ser Asn Ala Tyr Gly Val Ala Gln Ser Val Val Asn Leu Ser Val His
        3075                3080                3085            
Gly Pro Pro Thr Val Ser Val Leu Pro Glu Gly Pro Val Trp Val Lys
    3090                3095                3100                
Val Gly Lys Ala Val Thr Leu Glu Cys Val Ser Ala Gly Glu Pro Arg
3105                3110                3115                3120
Ser Ser Ala Arg Trp Thr Arg Ile Ser Ser Thr Pro Ala Lys Leu Glu
                3125                3130                3135    
Gln Arg Thr Tyr Gly Leu Met Asp Ser His Ala Val Leu Gln Ile Ser
            3140                3145                3150        
Ser Ala Lys Pro Ser Asp Ala Gly Thr Tyr Val Cys Leu Ala Gln Asn
        3155                3160                3165            
Ala Leu Gly Thr Ala Gln Lys Gln Val Glu Val Ile Val Asp Thr Gly
    3170                3175                3180                
Ala Met Ala Pro Gly Ala Pro Gln Val Gln Ala Glu Glu Ala Glu Leu
3185                3190                3195                3200
Thr Val Glu Ala Gly His Thr Ala Thr Leu Arg Cys Ser Ala Thr Gly
                3205                3210                3215    
Ser Pro Ala Pro Thr Ile His Trp Ser Lys Leu Arg Ser Pro Leu Pro
            3220                3225                3230        
Trp Gln His Arg Leu Glu Gly Asp Thr Leu Ile Ile Pro Arg Val Ala
        3235                3240                3245            
Gln Gln Asp Ser Gly Gln Tyr Ile Cys Asn Ala Thr Ser Pro Ala Gly
    3250                3255                3260                
His Ala Glu Ala Thr Ile Ile Leu His Val Glu Ser Pro Pro Tyr Ala
3265                3270                3275                3280
Thr Thr Val Pro Glu His Ala Ser Val Gln Ala Gly Glu Thr Val Gln
                3285                3290                3295    
Leu Gln Cys Leu Ala His Gly Thr Pro Pro Leu Thr Phe Gln Trp Ser
            3300                3305                3310        
Arg Val Gly Ser Ser Leu Pro Gly Arg Ala Thr Ala Arg Asn Glu Leu
        3315                3320                3325            
Leu His Phe Glu Arg Ala Ala Pro Glu Asp Ser Gly Arg Tyr Arg Cys
    3330                3335                3340                
Arg Val Thr Asn Lys Val Gly Ser Ala Glu Ala Phe Ala Gln Leu Leu
3345                3350                3355                3360
Val Gln Gly Pro Pro Gly Ser Leu Pro Ala Thr Ser Ile Pro Ala Gly
                3365                3370                3375    
Ser Thr Pro Thr Val Gln Val Thr Pro Gln Leu Glu Thr Lys Ser Ile
            3380                3385                3390        
Gly Ala Ser Val Glu Phe His Cys Ala Val Pro Ser Asp Arg Gly Thr
        3395                3400                3405            
Gln Leu Arg Trp Phe Lys Glu Gly Gly Gln Leu Pro Pro Gly His Ser
    3410                3415                3420                
Val Gln Asp Gly Val Leu Arg Ile Gln Asn Leu Asp Gln Ser Cys Gln
3425                3430                3435                3440
Gly Thr Tyr Ile Cys Gln Ala His Gly Pro Trp Gly Lys Ala Gln Ala
                3445                3450                3455    
Ser Ala Gln Leu Val Ile Gln Ala Leu Pro Ser Val Leu Ile Asn Ile
            3460                3465                3470        
Arg Thr Ser Val Gln Thr Val Val Val Gly His Ala Val Glu Phe Glu
        3475                3480                3485            
Cys Leu Ala Leu Gly Asp Pro Lys Pro Gln Val Thr Trp Ser Lys Val
    3490                3495                3500                
Gly Gly His Leu Arg Pro Gly Ile Val Gln Ser Gly Gly Val Val Arg
3505                3510                3515                3520
Ile Ala His Val Glu Leu Ala Asp Ala Gly Gln Tyr Arg Cys Thr Ala
                3525                3530                3535    
Thr Asn Ala Ala Gly Thr Thr Gln Ser His Val Leu Leu Leu Val Gln
            3540                3545                3550        
Ala Leu Pro Gln Ile Ser Met Pro Gln Glu Val Arg Val Pro Ala Gly
        3555                3560                3565            
Ser Ala Ala Val Phe Pro Cys Ile Ala Ser Gly Tyr Pro Thr Pro Asp
    3570                3575                3580                
Ile Ser Trp Ser Lys Leu Asp Gly Ser Leu Pro Pro Asp Ser Arg Leu
3585                3590                3595                3600
Glu Asn Asn Met Leu Met Leu Pro Ser Val Arg Pro Gln Asp Ala Gly
                3605                3610                3615    
Thr Tyr Val Cys Thr Ala Thr Asn Arg Gln Gly Lys Val Lys Ala Phe
            3620                3625                3630        
Ala His Leu Gln Val Pro Glu Arg Val Val Pro Tyr Phe Thr Gln Thr
        3635                3640                3645            
Pro Tyr Ser Phe Leu Pro Leu Pro Thr Ile Lys Asp Ala Tyr Arg Lys
    3650                3655                3660                
Phe Glu Ile Lys Ile Thr Phe Arg Pro Asp Ser Ala Asp Gly Met Leu
3665                3670                3675                3680
Leu Tyr Asn Gly Gln Lys Arg Val Pro Gly Ser Pro Thr Asn Leu Ala
                3685                3690                3695    
Asn Arg Gln Pro Asp Phe Ile Ser Phe Gly Leu Val Gly Gly Arg Pro
            3700                3705                3710        
Glu Phe Arg Phe Asp Ala Gly Ser Gly Met Ala Thr Ile Arg His Pro
        3715                3720                3725            
Thr Pro Leu Ala Leu Gly His Phe His Thr Val Thr Leu Leu Arg Ser
    3730                3735                3740                
Leu Thr Gln Gly Ser Leu Ile Val Gly Asp Leu Ala Pro Val Asn Gly
3745                3750                3755                3760
Thr Ser Gln Gly Lys Phe Gln Gly Leu Asp Leu Asn Glu Glu Leu Tyr
                3765                3770                3775    
Leu Gly Gly Tyr Pro Asp Tyr Gly Ala Ile Pro Lys Ala Gly Leu Ser
            3780                3785                3790        
Ser Gly Phe Ile Gly Cys Val Arg Glu Leu Arg Ile Gln Gly Glu Glu
        3795                3800                3805            
Ile Val Phe His Asp Leu Asn Leu Thr Ala His Gly Ile Ser His Cys
    3810                3815                3820                
Pro Thr Cys Arg Asp Arg Pro Cys Gln Asn Gly Gly Gln Cys His Asp
3825                3830                3835                3840
Ser Glu Ser Ser Ser Tyr Val Cys Val Cys Pro Ala Gly Phe Thr Gly
                3845                3850                3855    
Ser Arg Cys Glu His Ser Gln Ala Leu His Cys His Pro Glu Ala Cys
            3860                3865                3870        
Gly Pro Asp Ala Thr Cys Val Asn Arg Pro Asp Gly Arg Gly Tyr Thr
        3875                3880                3885            
Cys Arg Cys His Leu Gly Arg Ser Gly Leu Arg Cys Glu Glu Gly Val
    3890                3895                3900                
Thr Val Thr Thr Pro Ser Leu Ser Gly Ala Gly Ser Tyr Leu Ala Leu
3905                3910                3915                3920
Pro Ala Leu Thr Asn Thr His His Glu Leu Arg Leu Asp Val Glu Phe
                3925                3930                3935    
Lys Pro Leu Ala Pro Asp Gly Val Leu Leu Phe Ser Gly Gly Lys Ser
            3940                3945                3950        
Gly Pro Val Glu Asp Phe Val Ser Leu Ala Met Val Gly Gly His Leu
        3955                3960                3965            
Glu Phe Arg Tyr Glu Leu Gly Ser Gly Leu Ala Val Leu Arg Ser Ala
    3970                3975                3980                
Glu Pro Leu Ala Leu Gly Arg Trp His Arg Val Ser Ala Glu Arg Leu
3985                3990                3995                4000
Asn Lys Asp Gly Ser Leu Arg Val Asn Gly Gly Arg Pro Val Leu Arg
                4005                4010                4015    
Ser Ser Pro Gly Lys Ser Gln Gly Leu Asn Leu His Thr Leu Leu Tyr
            4020                4025                4030        
Leu Gly Gly Val Glu Pro Ser Val Pro Leu Ser Pro Ala Thr Asn Met
        4035                4040                4045            
Ser Ala His Phe Arg Gly Cys Val Gly Glu Val Ser Val Asn Gly Lys
    4050                4055                4060                
Arg Leu Asp Leu Thr Tyr Ser Phe Leu Gly Ser Gln Gly Ile Gly Gln
4065                4070                4075                4080
Cys Tyr Asp Ser Ser Pro Cys Glu Arg Gln Pro Cys Gln His Gly Ala
                4085                4090                4095    
Thr Cys Met Pro Ala Gly Glu Tyr Glu Phe Gln Cys Leu Cys Arg Asp
            4100                4105                4110        
Gly Phe Lys Gly Asp Leu Cys Glu His Glu Glu Asn Pro Cys Gln Leu
        4115                4120                4125            
Arg Glu Pro Cys Leu His Gly Gly Thr Cys Gln Gly Thr Arg Cys Leu
    4130                4135                4140                
Cys Leu Pro Gly Phe Ser Gly Pro Arg Cys Gln Gln Gly Ser Gly His
4145                4150                4155                4160
Gly Ile Ala Glu Ser Asp Trp His Leu Glu Gly Ser Gly Gly Asn Asp
                4165                4170                4175    
Ala Pro Gly Gln Tyr Gly Ala Tyr Phe His Asp Asp Gly Phe Leu Ala
            4180                4185                4190        
Phe Pro Gly His Val Phe Ser Arg Ser Leu Pro Glu Val Pro Glu Thr
        4195                4200                4205            
Ile Glu Leu Glu Val Arg Thr Ser Thr Ala Ser Gly Leu Leu Leu Trp
    4210                4215                4220                
Gln Gly Val Glu Val Gly Glu Ala Gly Gln Gly Lys Asp Phe Ile Ser
4225                4230                4235                4240
Leu Gly Leu Gln Asp Gly His Leu Val Phe Arg Tyr Gln Leu Gly Ser
                4245                4250                4255    
Gly Glu Ala Arg Leu Val Ser Glu Asp Pro Ile Asn Asp Gly Glu Trp
            4260                4265                4270        
His Arg Val Thr Ala Leu Arg Glu Gly Arg Arg Gly Ser Ile Gln Val
        4275                4280                4285            
Asp Gly Glu Glu Leu Val Ser Gly Arg Ser Pro Gly Pro Asn Val Ala
    4290                4295                4300                
Val Asn Ala Lys Gly Ser Val Tyr Ile Gly Gly Ala Pro Asp Val Ala
4305                4310                4315                4320
Thr Leu Thr Gly Gly Arg Phe Ser Ser Gly Ile Thr Gly Cys Val Lys
                4325                4330                4335    
Asn Leu Val Leu His Ser Ala Arg Pro Gly Ala Pro Pro Pro Gln Pro
            4340                4345                4350        
Leu Asp Leu Gln His Arg Ala Gln Ala Gly Ala Asn Thr Arg Pro Cys
        4355                4360                4365            
Pro Ser
    4370


<210> 1268
<211> 1001
<212> PRT
<213> Homo sapiens

<400> 1268
Met Gly Asn Ser Tyr Ala Gly Gln Leu Lys Thr Thr Arg Phe Glu Glu
 1               5                  10                  15      
Val Leu His Asn Ser Ile Glu Ala Ser Leu Arg Ser Asn Asn Leu Val
            20                  25                  30          
Pro Arg Pro Ile Phe Ser Gln Leu Tyr Leu Glu Ala Glu Gln Gln Leu
        35                  40                  45              
Ala Ala Leu Glu Gly Gly Ser Arg Val Asp Asn Glu Glu Glu Glu Glu
    50                  55                  60                  
Glu Gly Glu Gly Gly Leu Glu Thr Asn Gly Pro Pro Asn Pro Phe Gln
65                  70                  75                  80  
Leu His Pro Leu Pro Glu Gly Cys Cys Thr Thr Asp Gly Phe Cys Gln
                85                  90                  95      
Ala Gly Lys Asp Leu Arg Leu Val Ser Ile Ser Asn Glu Pro Met Asp
            100                 105                 110         
Val Pro Ala Gly Phe Leu Leu Val Gly Val Lys Ser Pro Ser Leu Pro
        115                 120                 125             
Asp His Leu Leu Val Cys Ala Val Asp Lys Arg Phe Leu Pro Asp Asp
    130                 135                 140                 
Asn Gly His Asn Ala Leu Leu Gly Phe Ser Gly Asn Cys Val Gly Cys
145                 150                 155                 160 
Gly Lys Lys Gly Phe Cys Tyr Phe Thr Glu Phe Ser Asn His Ile Asn
                165                 170                 175     
Leu Lys Leu Thr Thr Gln Pro Lys Lys Gln Lys His Leu Lys Tyr Tyr
            180                 185                 190         
Leu Val Arg Asn Ala Gln Gly Thr Leu Thr Lys Gly Pro Leu Ile Cys
        195                 200                 205             
Trp Lys Gly Ser Glu Phe Arg Ser Arg Gln Ile Pro Ala Ser Thr Cys
    210                 215                 220                 
Ser Ser Ser Leu Phe Pro Ala Leu Glu Ser Thr Ala Ala Phe Pro Ser
225                 230                 235                 240 
Glu Pro Val Pro Gly Thr Asn Pro Ser Ile Leu Met Gly Ala Gln Gln
                245                 250                 255     
Ala Gly Pro Ala Ser Asp His Pro Ser Leu Asn Ala Ala Met Gly Pro
            260                 265                 270         
Ala Val Phe Asn Gly Lys Asp Ser Pro Lys Cys Gln Gln Leu Ala Lys
        275                 280                 285             
Asn Asn Leu Leu Ala Leu Pro Arg Pro Ser Ala Leu Gly Ile Leu Ser
    290                 295                 300                 
Asn Ser Gly Pro Pro Lys Lys Arg His Lys Gly Trp Ser Pro Glu Ser
305                 310                 315                 320 
Pro Ser Ala Pro Asp Gly Gly Cys Pro Gln Gly Gly Gly Asn Arg Ala
                325                 330                 335     
Lys Tyr Glu Ser Ala Gly Met Ser Cys Val Pro Gln Val Gly Leu Val
            340                 345                 350         
Gly Pro Ala Ser Val Thr Phe Pro Val Val Ala Ser Gly Glu Pro Val
        355                 360                 365             
Ser Val Pro Asp Asn Leu Leu Lys Ile Cys Lys Ala Lys Pro Val Ile
    370                 375                 380                 
Phe Lys Gly His Gly Asn Phe Pro Tyr Leu Cys Gly Asn Leu Asn Asp
385                 390                 395                 400 
Val Val Val Ser Pro Leu Leu Tyr Thr Cys Tyr Gln Asn Ser Gln Ser
                405                 410                 415     
Val Ser Arg Ala Tyr Glu Gln Tyr Gly Ala Ser Ala Ile Gln Pro Ile
            420                 425                 430         
Ser Glu Glu Met Gln Leu Leu Leu Thr Val Tyr Tyr Leu Val Gln Leu
        435                 440                 445             
Ala Ala Asp Gln Val Pro Leu Met Glu Asp Leu Glu Gln Ile Phe Leu
    450                 455                 460                 
Arg Ser Trp Arg Glu Ser His Leu Thr Glu Ile Arg Gln Tyr Gln Gln
465                 470                 475                 480 
Ala Pro Pro Gln Pro Phe Pro Pro Ala Pro Ser Ala Ala Ala Pro Val
                485                 490                 495     
Thr Ser Ala Gln Leu Pro Trp Leu Ala Ser Leu Ala Ala Ser Ser Cys
            500                 505                 510         
Asn Asp Ser Val His Val Ile Glu Cys Ala Tyr Ser Leu Ala Glu Gly
        515                 520                 525             
Leu Ser Glu Met Phe Arg Leu Leu Val Glu Gly Lys Leu Ala Lys Thr
    530                 535                 540                 
Asn Tyr Val Val Ile Ile Cys Ala Cys Arg Ser Ala Ala Ile Asp Ser
545                 550                 555                 560 
Cys Ile Ala Val Thr Gly Lys Tyr Gln Ala Arg Ile Leu Ser Glu Ser
                565                 570                 575     
Leu Leu Thr Pro Ala Glu Tyr Gln Lys Glu Val Asn Tyr Glu Leu Val
            580                 585                 590         
Thr Gly Lys Val Asp Ser Leu Gly Ala Phe Phe Ser Thr Leu Cys Pro
        595                 600                 605             
Glu Gly Asp Ile Asp Ile Leu Leu Asp Lys Phe His Gln Glu Asn Gln
    610                 615                 620                 
Gly His Ile Ser Ser Ser Leu Ala Ala Ser Ser Val Thr Lys Ala Ala
625                 630                 635                 640 
Ser Leu Asp Val Ser Gly Thr Pro Val Cys Thr Ser Tyr Asn Leu Glu
                645                 650                 655     
Pro His Ser Ile Arg Pro Phe Gln Leu Ala Val Ala Gln Lys Leu Leu
            660                 665                 670         
Ser His Val Cys Ser Ile Ala Asp Ser Ser Thr Gln Asn Leu Asp Leu
        675                 680                 685             
Gly Ser Phe Glu Lys Val Asp Phe Leu Ile Cys Ile Pro Pro Ser Glu
    690                 695                 700                 
Val Thr Tyr Gln Gln Thr Leu Leu His Val Trp His Ser Gly Val Leu
705                 710                 715                 720 
Leu Glu Leu Gly Leu Lys Lys Glu His Met Thr Lys Gln Arg Val Glu
                725                 730                 735     
Gln Tyr Val Leu Lys Leu Asp Thr Glu Ala Gln Thr Lys Phe Lys Ala
            740                 745                 750         
Phe Leu Gln Asn Ser Phe Gln Asn Pro His Thr Leu Phe Val Leu Ile
        755                 760                 765             
His Asp His Ala His Trp Asp Leu Val Ser Ser Thr Val His Asn Leu
    770                 775                 780                 
Tyr Ser Gln Ser Asp Pro Ser Val Gly Leu Val Asp Arg Leu Leu Asn
785                 790                 795                 800 
Cys Arg Glu Val Lys Glu Ala Pro Asn Ile Val Thr Leu His Val Thr
                805                 810                 815     
Ser Phe Pro Tyr Ala Leu Gln Thr Gln His Thr Leu Ser Ser Pro Tyr
            820                 825                 830         
Asn Glu Ile His Trp Pro Ala Ser Cys Ser Asn Gly Val Asp Leu Tyr
        835                 840                 845             
His Glu Asn Lys Lys Tyr Phe Gly Leu Ser Glu Phe Ile Glu Ser Thr
    850                 855                 860                 
Leu Ser Gly His Ser Leu Pro Leu Leu Arg Tyr Asp Ser Ser Phe Glu
865                 870                 875                 880 
Ala Met Val Thr Ala Leu Gly Lys Arg Phe Pro Arg Leu His Ser Ala
                885                 890                 895     
Val Ile Arg Thr Phe Val Leu Val Gln His Tyr Ala Ala Ala Leu Met
            900                 905                 910         
Ala Val Ser Gly Leu Pro Gln Met Lys Asn Tyr Thr Ser Val Glu Thr
        915                 920                 925             
Leu Glu Ile Thr Gln Asn Leu Leu Asn Ser Pro Lys Gln Cys Pro Cys
    930                 935                 940                 
Gly His Gly Leu Met Val Leu Leu Arg Val Pro Cys Ser Pro Leu Ala
945                 950                 955                 960 
Val Val Ala Tyr Glu Arg Leu Ala His Val Arg Ala Arg Leu Ala Leu
                965                 970                 975     
Glu Glu His Phe Glu Ile Ile Leu Gly Ser Pro Ser Ser Gly Val Thr
            980                 985                 990         
Val Gly Lys His Phe Val Lys Gln Leu
        995                 1000    


<210> 1269
<211> 80
<212> PRT
<213> Homo sapiens

<400> 1269
Met Ala Thr Pro Thr Gln Thr Pro Thr Lys Ala Pro Glu Glu Pro Asp
 1               5                  10                  15      
Pro Phe Tyr Tyr Asp Tyr Asn Thr Val Gln Thr Val Gly Met Thr Leu
            20                  25                  30          
Ala Thr Ile Leu Phe Leu Leu Gly Ile Leu Ile Val Ile Ser Lys Lys
        35                  40                  45              
Val Lys Cys Arg Lys Ala Asp Ser Arg Ser Glu Ser Pro Thr Cys Lys
    50                  55                  60                  
Ser Cys Lys Ser Glu Leu Pro Ser Ser Ala Pro Gly Gly Gly Gly Val
65                  70                  75                  80  


<210> 1270
<211> 92
<212> PRT
<213> Homo sapiens

<400> 1270
Met Ala Ser Leu Gly His Ile Leu Val Phe Cys Val Gly Leu Leu Thr
 1               5                  10                  15      
Met Ala Lys Ala Glu Ser Pro Lys Glu His Asp Pro Phe Thr Tyr Asp
            20                  25                  30          
Tyr Gln Ser Leu Gln Ile Gly Gly Leu Val Ile Ala Gly Ile Leu Phe
        35                  40                  45              
Ile Leu Gly Ile Leu Ile Val Leu Ser Arg Arg Cys Arg Cys Lys Phe
    50                  55                  60                  
Asn Gln Gln Gln Arg Thr Gly Glu Pro Asp Glu Glu Glu Gly Thr Phe
65                  70                  75                  80  
Arg Ser Ser Ile Arg Arg Leu Ser Thr Arg Arg Arg
                85                  90          


<210> 1271
<211> 475
<212> PRT
<213> Homo sapiens

<400> 1271
Met Thr Thr Ile Leu Thr Tyr Pro Phe Lys Asn Leu Pro Thr Ala Ser
 1               5                  10                  15      
Lys Trp Ala Leu Arg Phe Ser Ile Arg Pro Leu Ser Cys Ser Ser Gln
            20                  25                  30          
Leu Arg Ala Ala Pro Ala Val Gln Thr Lys Thr Lys Lys Thr Leu Ala
        35                  40                  45              
Lys Pro Asn Ile Arg Asn Val Val Val Val Asp Gly Val Arg Thr Pro
    50                  55                  60                  
Phe Leu Leu Ser Gly Thr Ser Tyr Lys Asp Leu Met Pro His Asp Leu
65                  70                  75                  80  
Ala Arg Ala Ala Leu Thr Gly Leu Leu His Arg Thr Ser Val Pro Lys
                85                  90                  95      
Glu Val Val Asp Tyr Ile Ile Phe Gly Thr Val Ile Gln Glu Val Lys
            100                 105                 110         
Thr Ser Asn Val Ala Arg Glu Ala Ala Leu Gly Ala Gly Phe Ser Asp
        115                 120                 125             
Lys Thr Pro Ala His Thr Val Thr Met Ala Cys Ile Ser Ala Asn Gln
    130                 135                 140                 
Ala Met Thr Thr Gly Val Gly Leu Ile Ala Ser Gly Gln Cys Asp Val
145                 150                 155                 160 
Ile Val Ala Gly Gly Val Glu Leu Met Ser Asp Val Pro Ile Arg His
                165                 170                 175     
Ser Arg Lys Met Arg Lys Leu Met Leu Asp Leu Asn Lys Ala Lys Ser
            180                 185                 190         
Met Gly Gln Arg Leu Ser Leu Ile Ser Lys Phe Arg Phe Asn Phe Leu
        195                 200                 205             
Ala Pro Glu Leu Pro Ala Val Ser Glu Phe Ser Thr Ser Glu Thr Met
    210                 215                 220                 
Gly His Ser Ala Asp Arg Leu Ala Ala Ala Phe Ala Val Ser Arg Leu
225                 230                 235                 240 
Glu Gln Asp Glu Tyr Ala Leu Arg Ser His Ser Leu Ala Lys Lys Ala
                245                 250                 255     
Gln Asp Glu Gly Leu Leu Ser Asp Val Val Pro Phe Lys Val Pro Gly
            260                 265                 270         
Lys Asp Thr Val Thr Lys Asp Asn Gly Ile Arg Pro Ser Ser Leu Glu
        275                 280                 285             
Gln Met Ala Lys Leu Lys Pro Ala Phe Ile Lys Pro Tyr Gly Thr Val
    290                 295                 300                 
Thr Ala Ala Asn Ser Ser Phe Leu Thr Asp Gly Ala Ser Ala Met Leu
305                 310                 315                 320 
Ile Met Ala Glu Glu Lys Ala Leu Ala Met Gly Tyr Lys Pro Lys Ala
                325                 330                 335     
Tyr Leu Arg Asp Phe Met Tyr Val Ser Gln Asp Pro Lys Asp Gln Leu
            340                 345                 350         
Leu Leu Gly Pro Thr Tyr Ala Thr Pro Lys Val Leu Glu Lys Ala Gly
        355                 360                 365             
Leu Thr Met Asn Asp Ile Asp Ala Phe Glu Phe His Glu Ala Phe Ser
    370                 375                 380                 
Gly Gln Ile Leu Ala Asn Phe Lys Ala Met Asp Ser Asp Trp Phe Ala
385                 390                 395                 400 
Glu Asn Tyr Met Gly Arg Lys Thr Lys Val Gly Leu Pro Pro Leu Glu
                405                 410                 415     
Lys Phe Asn Asn Trp Gly Gly Ser Leu Ser Leu Gly His Pro Phe Gly
            420                 425                 430         
Ala Thr Gly Cys Arg Leu Val Met Ala Ala Ala Asn Arg Leu Arg Lys
        435                 440                 445             
Glu Gly Gly Gln Tyr Gly Leu Val Ala Ala Cys Ala Ala Gly Gly Gln
    450                 455                 460                 
Gly His Ala Met Ile Val Glu Ala Tyr Pro Lys
465                 470                 475 


<210> 1272
<211> 248
<212> PRT
<213> Homo sapiens

<400> 1272
Met Arg Pro Val Arg Leu Met Lys Val Phe Val Thr Arg Arg Ile Pro
 1               5                  10                  15      
Ala Glu Gly Arg Val Ala Leu Ala Arg Ala Ala Asp Cys Glu Val Glu
            20                  25                  30          
Gln Trp Asp Ser Asp Glu Pro Ile Pro Ala Lys Glu Leu Glu Arg Gly
        35                  40                  45              
Val Ala Gly Ala His Gly Leu Leu Cys Leu Leu Ser Asp His Val Asp
    50                  55                  60                  
Lys Arg Ile Leu Asp Ala Ala Gly Ala Asn Leu Lys Val Ile Ser Thr
65                  70                  75                  80  
Met Ser Val Gly Ile Asp His Leu Ala Leu Asp Glu Ile Lys Lys Arg
                85                  90                  95      
Gly Ile Arg Val Gly Tyr Thr Pro Asp Val Leu Thr Asp Thr Thr Ala
            100                 105                 110         
Glu Leu Ala Val Ser Leu Leu Leu Thr Thr Cys Arg Arg Leu Pro Glu
        115                 120                 125             
Ala Ile Glu Glu Val Lys Asn Gly Gly Trp Thr Ser Trp Lys Pro Leu
    130                 135                 140                 
Trp Leu Cys Gly Tyr Gly Leu Thr Gln Ser Thr Val Gly Ile Ile Gly
145                 150                 155                 160 
Leu Gly Arg Ile Gly Gln Ala Ile Ala Arg Arg Leu Lys Pro Phe Gly
                165                 170                 175     
Val Gln Arg Phe Leu Tyr Thr Gly Arg Gln Pro Arg Pro Glu Glu Ala
            180                 185                 190         
Ala Glu Phe Gln Ala Glu Phe Val Ser Thr Pro Glu Leu Ala Ala Gln
        195                 200                 205             
Ser Asp Phe Ile Val Val Ala Cys Ser Leu Thr Pro Ala Thr Glu Gly
    210                 215                 220                 
Leu Cys Asn Lys Asp Phe Phe Gln Lys Met Lys Glu Gln Leu Cys Ser
225                 230                 235                 240 
Ser Thr Ser Ala Gly Ala Thr Ser
                245             


<210> 1273
<211> 366
<212> PRT
<213> Homo sapiens

<400> 1273
Met Leu Pro Ser Leu Gln Glu Ser Met Asp Gly Asp Glu Lys Glu Leu
 1               5                  10                  15      
Glu Ser Ser Glu Glu Gly Gly Ser Ala Glu Glu Arg Arg Leu Glu Pro
            20                  25                  30          
Pro Ser Ser Ser His Tyr Cys Leu Tyr Ser Tyr Arg Gly Ser Arg Leu
        35                  40                  45              
Ala Gln Gln Arg Gly Asp Ser Glu Asp Gly Ser Pro Ser Gly Thr Asn
    50                  55                  60                  
Ala Glu Thr Pro Ser Gly Asp Asp Phe Ser Leu Ser Leu Ala Asp Thr
65                  70                  75                  80  
Asn Leu Pro Ser Glu Val Glu Pro Glu Leu Arg Ser Phe Ile Ala Lys
                85                  90                  95      
Arg Leu Ser Arg Gly Ala Val Phe Glu Gly Leu Gly Asn Val Ala Ser
            100                 105                 110         
Val Glu Leu Lys Ile Pro Gly Tyr Arg Val Gly Cys Tyr Tyr Cys Leu
        115                 120                 125             
Phe Gln Asn Glu Lys Leu Leu Pro Glu Thr Val Thr Ile Asp Ser Glu
    130                 135                 140                 
Arg Asn Pro Ser Glu Tyr Val Val Cys Phe Leu Gly Gly Ser Glu Lys
145                 150                 155                 160 
Gly Leu Glu Leu Phe Arg Leu Glu Leu Asp Lys Tyr Ile Gln Gly Leu
                165                 170                 175     
Lys Asn Asn Met Asn Cys Glu Ala Arg Gly Leu Glu Ser His Ile Lys
            180                 185                 190         
Ser Tyr Leu Ser Ser Trp Phe Glu Asp Val Val Cys Pro Ile Gln Arg
        195                 200                 205             
Val Val Leu Leu Phe Gln Glu Lys Leu Thr Phe Leu Leu His Ala Ala
    210                 215                 220                 
Leu Ser Tyr Thr Pro Val Glu Val Lys Glu Ser Asp Glu Lys Thr Lys
225                 230                 235                 240 
Arg Asp Ile Asn Arg Phe Leu Ser Val Ala Ser Leu Gln Gly Leu Ile
                245                 250                 255     
His Glu Gly Thr Met Thr Ser Leu Cys Met Ala Met Thr Glu Glu Gln
            260                 265                 270         
His Lys Ser Val Val Ile Asp Cys Ser Ser Ser Gln Pro Gln Phe Cys
        275                 280                 285             
Asn Ala Gly Ser Asn Arg Phe Cys Glu Asp Trp Met Gln Ala Phe Leu
    290                 295                 300                 
Asn Gly Ala Lys Gly Gly Asn Pro Phe Phe Phe Arg Gln Val Leu Glu
305                 310                 315                 320 
Asn Phe Lys Leu Lys Ala Ile Gln Asp Thr Asn Asn Leu Lys Arg Phe
                325                 330                 335     
Ile Arg Gln Ala Glu Met Asn His Tyr Ala Leu Phe Lys Cys Tyr Met
            340                 345                 350         
Phe Leu Lys Asn Cys Gly Ser Gly Asp Thr Phe Glu Asp Cys
        355                 360                 365     


<210> 1274
<211> 402
<212> PRT
<213> Homo sapiens

<400> 1274
Met Met Val His Cys Ala Gly Cys Glu Arg Pro Ile Leu Asp Arg Phe
 1               5                  10                  15      
Leu Leu Asn Val Leu Asp Arg Ala Trp His Ile Lys Cys Val Gln Cys
            20                  25                  30          
Cys Glu Cys Lys Thr Asn Leu Ser Glu Lys Cys Phe Ser Arg Glu Gly
        35                  40                  45              
Lys Leu Tyr Cys Lys Asn Asp Phe Phe Arg Arg Phe Gly Thr Lys Cys
    50                  55                  60                  
Ala Gly Cys Ala Gln Gly Ile Ser Pro Ser Asp Leu Val Arg Lys Ala
65                  70                  75                  80  
Arg Ser Lys Val Phe His Leu Asn Cys Phe Thr Cys Met Val Cys Asn
                85                  90                  95      
Lys Gln Leu Ser Thr Gly Glu Glu Leu Tyr Val Ile Asp Glu Asn Lys
            100                 105                 110         
Phe Val Cys Lys Asp Asp Tyr Leu Ser Ser Ser Ser Leu Lys Glu Gly
        115                 120                 125             
Ser Leu Asn Ser Val Ser Ser Cys Thr Asp Arg Ser Leu Ser Pro Asp
    130                 135                 140                 
Leu Gln Asp Ala Leu Gln Asp Asp Pro Lys Glu Thr Asp Asn Ser Thr
145                 150                 155                 160 
Ser Ser Asp Lys Glu Thr Ala Asn Asn Glu Asn Glu Glu Gln Asn Ser
                165                 170                 175     
Gly Thr Lys Arg Arg Gly Pro Arg Thr Thr Ile Lys Ala Lys Gln Leu
            180                 185                 190         
Glu Thr Leu Lys Ala Ala Phe Ala Ala Thr Pro Lys Pro Thr Arg His
        195                 200                 205             
Ile Arg Glu Gln Leu Ala Gln Glu Thr Gly Leu Asn Met Arg Val Ile
    210                 215                 220                 
Gln Val Trp Phe Gln Asn Arg Arg Ser Lys Glu Arg Arg Met Lys Gln
225                 230                 235                 240 
Leu Ser Ala Leu Gly Ala Arg Arg His Ala Phe Phe Arg Ser Pro Arg
                245                 250                 255     
Arg Met Arg Pro Leu Gly Gly Arg Leu Asp Glu Ser Glu Met Leu Gly
            260                 265                 270         
Ser Thr Pro Tyr Thr Tyr Tyr Gly Asp Tyr Gln Gly Asp Tyr Tyr Ala
        275                 280                 285             
Pro Gly Ser Asn Tyr Asp Phe Phe Ala His Gly Pro Pro Ser Gln Ala
    290                 295                 300                 
Gln Ser Pro Ala Asp Ser Ser Phe Leu Ala Ala Ser Gly Pro Gly Ser
305                 310                 315                 320 
Thr Pro Leu Gly Ala Leu Glu Pro Pro Leu Ala Gly Pro His Ala Ala
                325                 330                 335     
Asp Asn Pro Arg Phe Thr Asp Met Ile Ser His Pro Asp Thr Pro Ser
            340                 345                 350         
Pro Glu Pro Gly Leu Pro Gly Thr Leu His Pro Met Pro Gly Glu Val
        355                 360                 365             
Phe Ser Gly Gly Pro Ser Pro Pro Phe Pro Met Ser Gly Thr Ser Gly
    370                 375                 380                 
Tyr Ser Gly Pro Leu Ser His Pro Asn Pro Glu Leu Asn Glu Ala Ala
385                 390                 395                 400 
Val Trp
        


<210> 1275
<211> 580
<212> PRT
<213> Homo sapiens

<400> 1275
Met Glu Val Pro Gln Pro Glu Pro Ala Pro Gly Ser Ala Leu Ser Pro
 1               5                  10                  15      
Ala Gly Val Cys Gly Gly Ala Gln Arg Pro Gly His Leu Pro Gly Leu
            20                  25                  30          
Leu Leu Gly Ser His Gly Leu Leu Gly Ser Pro Val Arg Ala Ala Ala
        35                  40                  45              
Ser Ser Pro Val Thr Thr Leu Thr Gln Thr Met His Asp Leu Ala Gly
    50                  55                  60                  
Leu Gly Ser Glu Thr Pro Lys Ser Gln Val Gly Thr Leu Leu Phe Arg
65                  70                  75                  80  
Ser Arg Ser Arg Leu Thr His Leu Ser Leu Ser Arg Arg Ala Ser Glu
                85                  90                  95      
Ser Ser Leu Ser Ser Glu Ser Ser Glu Ser Ser Asp Ala Gly Leu Cys
            100                 105                 110         
Met Asp Ser Pro Ser Pro Met Asp Pro His Met Ala Glu Gln Thr Phe
        115                 120                 125             
Glu Gln Ala Ile Gln Ala Ala Ser Arg Ile Ile Arg Asn Glu Gln Phe
    130                 135                 140                 
Ala Ile Arg Arg Phe Gln Ser Met Pro Val Arg Leu Leu Gly His Ser
145                 150                 155                 160 
Pro Val Leu Arg Asn Ile Thr Asn Ser Gln Ala Pro Asp Gly Arg Arg
                165                 170                 175     
Lys Ser Glu Ala Gly Ser Gly Ala Ala Ser Ser Ser Gly Glu Asp Lys
            180                 185                 190         
Glu Asn Asp Gly Phe Val Phe Lys Met Pro Trp Lys Pro Thr His Pro
        195                 200                 205             
Ser Ser Thr His Ala Leu Ala Glu Trp Ala Ser Arg Arg Glu Ala Phe
    210                 215                 220                 
Ala Gln Arg Pro Ser Ser Ala Pro Asp Leu Met Cys Leu Ser Pro Asp
225                 230                 235                 240 
Arg Lys Met Glu Val Glu Glu Leu Ser Pro Leu Ala Leu Gly Arg Phe
                245                 250                 255     
Ser Leu Thr Pro Ala Glu Gly Asp Thr Glu Glu Asp Asp Gly Phe Val
            260                 265                 270         
Asp Ile Leu Glu Ser Asp Leu Lys Asp Asp Asp Ala Val Pro Pro Gly
        275                 280                 285             
Met Glu Ser Leu Ile Ser Ala Pro Leu Val Lys Thr Leu Glu Lys Glu
    290                 295                 300                 
Glu Glu Lys Asp Leu Val Met Tyr Ser Lys Cys Gln Arg Leu Phe Arg
305                 310                 315                 320 
Ser Pro Ser Met Pro Cys Ser Val Ile Arg Pro Ile Leu Lys Arg Leu
                325                 330                 335     
Glu Arg Pro Gln Asp Arg Asp Thr Pro Val Gln Asn Lys Arg Arg Arg
            340                 345                 350         
Ser Val Thr Pro Pro Glu Glu Gln Gln Glu Ala Glu Glu Pro Lys Ala
        355                 360                 365             
Arg Val Leu Arg Ser Lys Ser Leu Cys His Asp Glu Ile Glu Asn Leu
    370                 375                 380                 
Leu Asp Ser Asp His Arg Glu Leu Ile Gly Asp Tyr Ser Lys Ala Phe
385                 390                 395                 400 
Leu Leu Gln Thr Val Asp Gly Lys His Gln Asp Leu Lys Tyr Ile Ser
                405                 410                 415     
Pro Glu Thr Met Val Ala Leu Leu Thr Gly Lys Phe Ser Asn Ile Val
            420                 425                 430         
Asp Lys Phe Val Ile Val Asp Cys Arg Tyr Pro Tyr Glu Tyr Glu Gly
        435                 440                 445             
Gly His Ile Lys Thr Ala Val Asn Leu Pro Leu Glu Arg Asp Ala Glu
    450                 455                 460                 
Ser Phe Leu Leu Lys Ser Pro Ile Ala Pro Cys Ser Leu Asp Lys Arg
465                 470                 475                 480 
Val Ile Leu Ile Phe His Cys Glu Phe Ser Ser Glu Arg Gly Pro Arg
                485                 490                 495     
Met Cys Arg Phe Ile Arg Glu Arg Asp Arg Ala Val Asn Asp Tyr Pro
            500                 505                 510         
Ser Leu Tyr Tyr Pro Glu Met Tyr Ile Leu Lys Gly Gly Tyr Lys Glu
        515                 520                 525             
Phe Phe Pro Gln His Pro Asn Phe Cys Glu Pro Gln Asp Tyr Arg Pro
    530                 535                 540                 
Met Asn His Glu Ala Phe Lys Asp Glu Leu Lys Thr Phe Arg Leu Lys
545                 550                 555                 560 
Thr Arg Ser Trp Ala Gly Glu Arg Ser Arg Arg Glu Leu Cys Ser Arg
                565                 570                 575     
Leu Gln Asp Gln
            580 


<210> 1276
<211> 298
<212> PRT
<213> Homo sapiens

<400> 1276
Met Thr Glu Pro Gly Ala Ser Pro Glu Asp Pro Trp Val Lys Ala Ser
 1               5                  10                  15      
Pro Val Gly Ala His Ala Gly Glu Gly Arg Ala Gly Arg Ala Arg Ala
            20                  25                  30          
Arg Arg Gly Ala Gly Arg Arg Gly Ala Ser Leu Leu Ser Pro Lys Ser
        35                  40                  45              
Pro Thr Leu Ser Val Pro Arg Gly Cys Arg Glu Asp Ser Ser His Pro
    50                  55                  60                  
Ala Cys Ala Lys Val Glu Tyr Ala Tyr Ser Asp Asn Ser Leu Asp Pro
65                  70                  75                  80  
Gly Leu Phe Val Glu Ser Thr Arg Lys Gly Ser Val Val Ser Arg Ala
                85                  90                  95      
Asn Ser Ile Gly Ser Thr Ser Ala Ser Ser Val Pro Asn Thr Asp Asp
            100                 105                 110         
Glu Asp Ser Asp Tyr His Gln Glu Ala Tyr Lys Glu Ser Tyr Lys Asp
        115                 120                 125             
Arg Arg Arg Arg Ala His Thr Gln Ala Glu Gln Lys Arg Arg Asp Ala
    130                 135                 140                 
Ile Lys Arg Gly Tyr Asp Asp Leu Gln Thr Ile Val Pro Thr Cys Gln
145                 150                 155                 160 
Gln Gln Asp Phe Ser Ile Gly Ser Gln Lys Leu Ser Lys Ala Ile Val
                165                 170                 175     
Leu Gln Lys Thr Ile Asp Tyr Ile Gln Phe Leu His Lys Glu Lys Lys
            180                 185                 190         
Lys Gln Glu Glu Glu Val Ser Thr Leu Arg Lys Asp Val Thr Ala Leu
        195                 200                 205             
Lys Ile Met Lys Val Asn Tyr Glu Gln Ile Val Lys Ala His Gln Asp
    210                 215                 220                 
Asn Pro His Glu Gly Glu Asp Gln Val Ser Asp Gln Val Lys Phe Asn
225                 230                 235                 240 
Val Phe Gln Gly Ile Met Asp Ser Leu Phe Gln Ser Phe Asn Ala Ser
                245                 250                 255     
Ile Ser Val Ala Ser Phe Gln Glu Leu Ser Ala Cys Val Phe Ser Trp
            260                 265                 270         
Ile Glu Glu His Cys Lys Pro Gln Thr Leu Arg Glu Ile Val Ile Gly
        275                 280                 285             
Val Leu His Gln Leu Lys Asn Gln Leu Tyr
    290                 295             


<210> 1277
<211> 126
<212> PRT
<213> Homo sapiens

<400> 1277
Gly Pro Leu Leu Trp Val Gly Pro Leu Lys Arg Leu Gly Arg His Arg
 1               5                  10                  15      
Gly Arg Leu Glu Ala Leu Leu Pro Gly Gly Asp Thr Gln Ser Arg Arg
            20                  25                  30          
His Arg Gly Ala Gly Cys Val Arg Trp Leu Ala Gly Ala Ala Leu Pro
        35                  40                  45              
Cys Ser Leu Ala Pro Gly Cys Gly Ala Ala Ala Gly Ala Ser Pro Cys
    50                  55                  60                  
Pro Gly Ala Gly Arg Arg Arg Ala Ala Gly Arg Arg Cys Leu Ala Cys
65                  70                  75                  80  
Glu Cys Thr Ser Leu Thr Cys Ala Gly Glu Ser Gly Lys Ser Thr Ile
                85                  90                  95      
Val Lys Gln Met Arg Ile Leu His Val Asn Gly Phe Asn Gly Glu Gly
            100                 105                 110         
Gly Glu Glu Asp Pro Gln Ala Ala Arg Ser Asn Ser Asp Gly
        115                 120                 125     


<210> 1278
<211> 715
<212> PRT
<213> Homo sapiens

<400> 1278
Met Asn Ser Pro Lys Ser Lys Lys Ala Lys Lys Lys Glu Glu Pro Ser
 1               5                  10                  15      
Gln Asn Asp Ile Ser Pro Lys Thr Lys Ser Leu Arg Lys Lys Lys Glu
            20                  25                  30          
Pro Ile Glu Lys Lys Val Val Ser Ser Lys Thr Lys Lys Val Thr Lys
        35                  40                  45              
Asn Glu Glu Pro Ser Glu Glu Glu Ile Asp Ala Pro Lys Pro Lys Lys
    50                  55                  60                  
Met Lys Lys Glu Lys Glu Met Asn Gly Glu Thr Arg Glu Lys Ser Pro
65                  70                  75                  80  
Lys Leu Lys Asn Gly Phe Pro His Pro Glu Pro Asp Cys Asn Pro Ser
                85                  90                  95      
Glu Ala Ala Ser Glu Glu Ser Asn Ser Glu Ile Glu Gln Glu Ile Pro
            100                 105                 110         
Val Glu Gln Lys Glu Gly Ala Phe Ser Asn Phe Pro Ile Ser Glu Glu
        115                 120                 125             
Thr Ile Lys Leu Leu Lys Gly Arg Gly Val Thr Phe Leu Phe Pro Ile
    130                 135                 140                 
Gln Ala Lys Thr Phe His His Val Tyr Ser Gly Lys Asp Leu Ile Ala
145                 150                 155                 160 
Gln Ala Arg Thr Gly Thr Gly Lys Thr Phe Ser Phe Ala Ile Pro Leu
                165                 170                 175     
Ile Glu Lys Leu His Gly Glu Leu Gln Asp Arg Lys Arg Gly Arg Ala
            180                 185                 190         
Pro Gln Val Leu Val Leu Ala Pro Thr Arg Glu Leu Cys Asn Gln Val
        195                 200                 205             
Ser Lys Asp Phe Ser Asp Ile Thr Lys Lys Leu Ser Val Ala Cys Phe
    210                 215                 220                 
Tyr Gly Gly Thr Pro Tyr Gly Gly Gln Phe Glu Arg Met Arg Asn Gly
225                 230                 235                 240 
Ile Asp Ile Leu Val Gly Thr Pro Gly Arg Ile Lys Asp His Ile Gln
                245                 250                 255     
Asn Gly Lys Leu Asp Leu Thr Lys Leu Lys His Val Val Leu Asp Glu
            260                 265                 270         
Val Asp Gln Met Leu Asp Met Gly Phe Ala Asp Gln Val Glu Glu Ile
        275                 280                 285             
Leu Ser Val Ala Tyr Lys Lys Asp Ser Glu Asp Asn Pro Gln Thr Leu
    290                 295                 300                 
Leu Phe Ser Ala Thr Cys Pro His Trp Val Phe Asn Val Ala Lys Lys
305                 310                 315                 320 
Tyr Met Lys Ser Thr Tyr Glu Gln Val Asp Leu Ile Gly Lys Lys Thr
                325                 330                 335     
Gln Lys Thr Ala Ile Thr Val Glu His Leu Ala Ile Lys Cys His Trp
            340                 345                 350         
Thr Gln Arg Ala Ala Val Ile Gly Asp Val Ile Arg Val Tyr Ser Gly
        355                 360                 365             
His Gln Gly Arg Thr Ile Ile Phe Cys Glu Thr Lys Lys Glu Ala Gln
    370                 375                 380                 
Glu Leu Ser Gln Asn Ser Ala Ile Lys Gln Asp Ala Gln Ser Leu His
385                 390                 395                 400 
Gly Asp Ile Pro Gln Lys Gln Arg Glu Ile Thr Leu Lys Gly Phe Arg
                405                 410                 415     
Asn Gly Ser Phe Gly Val Leu Val Ala Thr Asn Val Ala Ala Arg Gly
            420                 425                 430         
Leu Asp Ile Pro Glu Val Asp Leu Val Ile Gln Ser Ser Pro Pro Lys
        435                 440                 445             
Asp Val Glu Ser Tyr Ile His Arg Ser Gly Arg Thr Gly Arg Ala Gly
    450                 455                 460                 
Arg Thr Gly Val Cys Ile Cys Phe Tyr Gln His Lys Glu Glu Tyr Gln
465                 470                 475                 480 
Leu Val Gln Val Glu Gln Lys Ala Gly Ile Lys Phe Lys Arg Ile Gly
                485                 490                 495     
Val Pro Ser Ala Thr Glu Ile Ile Lys Ala Ser Ser Lys Asp Ala Ile
            500                 505                 510         
Arg Leu Leu Asp Ser Val Pro Pro Thr Ala Ile Ser His Phe Lys Gln
        515                 520                 525             
Ser Ala Glu Lys Leu Ile Glu Glu Lys Gly Ala Val Glu Ala Leu Ala
    530                 535                 540                 
Ala Ala Leu Ala His Ile Ser Gly Ala Thr Ser Val Asp Gln Arg Ser
545                 550                 555                 560 
Leu Ile Asn Ser Asn Val Gly Phe Val Thr Met Ile Leu Gln Cys Ser
                565                 570                 575     
Ile Glu Met Pro Asn Ile Ser Tyr Ala Trp Lys Glu Leu Lys Glu Gln
            580                 585                 590         
Leu Gly Glu Glu Ile Asp Ser Lys Val Lys Gly Met Val Phe Leu Lys
        595                 600                 605             
Gly Lys Leu Gly Val Cys Phe Asp Val Pro Thr Ala Ser Val Thr Glu
    610                 615                 620                 
Ile Gln Glu Lys Trp His Asp Ser Arg Arg Trp Gln Leu Ser Val Ala
625                 630                 635                 640 
Thr Glu Gln Pro Glu Leu Glu Gly Pro Arg Glu Gly Tyr Gly Gly Phe
                645                 650                 655     
Arg Gly Gln Arg Glu Gly Ser Arg Gly Phe Arg Gly Gln Arg Asp Gly
            660                 665                 670         
Asn Arg Arg Phe Arg Gly Gln Arg Glu Gly Ser Arg Gly Pro Arg Gly
        675                 680                 685             
Gln Arg Ser Gly Gly Gly Asn Lys Ser Asn Arg Ser Gln Asn Lys Gly
    690                 695                 700                 
Gln Lys Arg Ser Phe Ser Lys Ala Phe Gly Gln
705                 710                 715 


<210> 1279
<211> 470
<212> PRT
<213> Homo sapiens

<400> 1279
Met Ser Gln Ala Tyr Ser Ser Ser Gln Arg Val Ser Ser Tyr Arg Arg
 1               5                  10                  15      
Thr Phe Gly Gly Ala Pro Gly Phe Pro Leu Gly Ser Pro Leu Ser Ser
            20                  25                  30          
Pro Val Phe Pro Arg Ala Gly Phe Gly Ser Lys Gly Ser Ser Ser Ser
        35                  40                  45              
Val Thr Ser Arg Val Tyr Gln Val Ser Arg Thr Ser Gly Gly Ala Gly
    50                  55                  60                  
Gly Leu Gly Ser Leu Arg Ala Ser Arg Leu Gly Thr Thr Arg Thr Pro
65                  70                  75                  80  
Ser Ser Tyr Gly Ala Gly Glu Leu Leu Asp Phe Ser Leu Ala Asp Ala
                85                  90                  95      
Val Asn Gln Glu Phe Leu Thr Thr Arg Thr Asn Glu Lys Val Glu Leu
            100                 105                 110         
Gln Glu Leu Asn Asp Arg Phe Ala Asn Tyr Ile Glu Lys Val Arg Phe
        115                 120                 125             
Leu Glu Gln Gln Asn Ala Ala Leu Ala Ala Glu Val Asn Arg Leu Lys
    130                 135                 140                 
Gly Arg Glu Pro Thr Arg Val Ala Glu Leu Tyr Glu Glu Glu Leu Arg
145                 150                 155                 160 
Glu Leu Arg Arg Gln Val Glu Val Leu Thr Asn Gln Arg Ala Arg Val
                165                 170                 175     
Asp Val Glu Arg Asp Asn Leu Leu Asp Asp Leu Gln Arg Leu Lys Ala
            180                 185                 190         
Lys Leu Gln Glu Glu Ile Gln Leu Lys Glu Glu Ala Glu Asn Asn Leu
        195                 200                 205             
Ala Ala Phe Arg Ala Asp Val Asp Ala Ala Thr Leu Ala Arg Ile Asp
    210                 215                 220                 
Leu Glu Arg Arg Ile Glu Ser Leu Asn Glu Glu Ile Ala Phe Leu Lys
225                 230                 235                 240 
Lys Val His Glu Glu Glu Ile Arg Glu Leu Gln Ala Gln Leu Gln Glu
                245                 250                 255     
Gln Gln Val Gln Val Glu Met Asp Met Ser Lys Pro Asp Leu Thr Ala
            260                 265                 270         
Ala Leu Arg Asp Ile Arg Ala Gln Tyr Glu Thr Ile Ala Ala Lys Asn
        275                 280                 285             
Ile Ser Glu Ala Glu Glu Trp Tyr Lys Ser Lys Val Ser Asp Leu Thr
    290                 295                 300                 
Gln Ala Ala Asn Lys Asn Asn Asp Ala Leu Arg Gln Ala Lys Gln Glu
305                 310                 315                 320 
Met Met Glu Tyr Arg His Gln Ile Gln Ser Tyr Thr Cys Glu Ile Asp
                325                 330                 335     
Ala Leu Lys Gly Thr Asn Asp Ser Leu Met Arg Gln Met Arg Glu Leu
            340                 345                 350         
Glu Asp Arg Phe Ala Ser Glu Ala Ser Gly Tyr Gln Asp Asn Ile Ala
        355                 360                 365             
Arg Leu Glu Glu Glu Ile Arg His Leu Lys Asp Glu Met Ala Arg His
    370                 375                 380                 
Leu Arg Glu Tyr Gln Asp Leu Leu Asn Val Lys Met Ala Leu Asp Val
385                 390                 395                 400 
Glu Ile Ala Thr Tyr Trp Lys Leu Leu Glu Gly Glu Glu Ser Arg Ile
                405                 410                 415     
Asn Leu Pro Ile Gln Thr Tyr Ser Ala Leu Asn Phe Arg Glu Thr Ser
            420                 425                 430         
Pro Glu Gln Arg Gly Ser Glu Val His Thr Lys Lys Thr Val Met Ile
        435                 440                 445             
Lys Thr Ile Glu Thr Arg Asp Gly Glu Val Val Ser Glu Ala Thr Gln
    450                 455                 460                 
Gln Gln His Glu Val Leu
465                 470 


<210> 1280
<211> 740
<212> PRT
<213> Homo sapiens

<400> 1280
Met Ala Thr Ala Asn Ser Ile Ile Val Leu Asp Asp Asp Asp Glu Asp
 1               5                  10                  15      
Glu Ala Ala Ala Gln Pro Gly Pro Ser His Pro Leu Pro Asn Ala Ala
            20                  25                  30          
Ser Pro Gly Ala Glu Ala Pro Ser Ser Ser Glu Pro His Gly Ala Arg
        35                  40                  45              
Gly Ser Ser Ser Ser Gly Gly Lys Lys Cys Tyr Lys Leu Glu Asn Glu
    50                  55                  60                  
Lys Leu Phe Glu Glu Phe Leu Glu Leu Cys Lys Met Gln Thr Ala Asp
65                  70                  75                  80  
His Pro Glu Val Val Pro Phe Leu Tyr Asn Arg Gln Gln Arg Ala His
                85                  90                  95      
Ser Leu Phe Leu Ala Ser Ala Glu Phe Cys Asn Ile Leu Ser Arg Val
            100                 105                 110         
Leu Ser Arg Ala Arg Ser Arg Pro Ala Lys Leu Tyr Val Tyr Ile Asn
        115                 120                 125             
Glu Leu Cys Thr Val Leu Lys Ala His Ser Ala Lys Lys Lys Leu Asn
    130                 135                 140                 
Leu Ala Pro Ala Ala Thr Thr Ser Asn Glu Pro Ser Gly Asn Asn Pro
145                 150                 155                 160 
Pro Thr His Leu Ser Leu Asp Pro Thr Asn Ala Glu Asn Thr Ala Ser
                165                 170                 175     
Arg Ser Pro Arg Thr Arg Gly Ser Arg Arg Gln Ile Gln Arg Leu Glu
            180                 185                 190         
Gln Leu Leu Ala Leu Tyr Val Ala Glu Ile Arg Arg Leu Gln Glu Lys
        195                 200                 205             
Glu Leu Asp Leu Ser Glu Leu Asp Asp Pro Asp Ser Ala Tyr Leu Gln
    210                 215                 220                 
Glu Ala Arg Leu Lys Arg Lys Leu Ile Arg Leu Phe Gly Arg Leu Cys
225                 230                 235                 240 
Glu Leu Lys Asp Cys Ser Ser Leu Thr Gly Arg Val Ile Glu Gln Arg
                245                 250                 255     
Ile Pro Tyr Arg Gly Thr Arg Tyr Pro Glu Val Asn Arg Arg Ile Glu
            260                 265                 270         
Arg Leu Ile Asn Lys Pro Gly Pro Asp Thr Phe Pro Asp Tyr Gly Asp
        275                 280                 285             
Val Leu Arg Ala Val Glu Lys Ala Ala Ala Arg His Ser Leu Gly Leu
    290                 295                 300                 
Pro Arg Gln Gln Leu Gln Leu Met Ala Gln Asp Ala Phe Arg Asp Val
305                 310                 315                 320 
Gly Ile Trp Leu Gln Glu Arg Arg His Leu Asp Leu Ile Tyr Asn Phe
                325                 330                 335     
Gly Cys His Leu Thr Asp Asp Tyr Arg Pro Gly Val Asp Pro Ala Leu
            340                 345                 350         
Ser Asp Pro Val Leu Ala Arg Arg Leu Arg Glu Asn Gln Ser Leu Ala
        355                 360                 365             
Met Ser Arg Leu Asp Glu Val Ile Ser Lys Tyr Ala Met Ser Gln Asp
    370                 375                 380                 
Lys Ser Glu Glu Gly Glu Arg Lys Lys Arg Arg Ala Arg Leu Gln Gly
385                 390                 395                 400 
Thr Ser Ser His Ser Ala Asp Thr Pro Glu Ala Ser Leu Asp Ser Gly
                405                 410                 415     
Glu Gly Pro Ser Gly Met Ala Ser Gln Gly Cys Pro Ser Ala Ser Arg
            420                 425                 430         
Ala Glu Thr Asp Asp Glu Asp Asp Glu Glu Ser Asp Glu Glu Glu Glu
        435                 440                 445             
Glu Glu Glu Glu Glu Glu Glu Glu Glu Ala Thr Asp Ser Glu Glu Glu
    450                 455                 460                 
Glu Asp Leu Glu Gln Met Gln Glu Gly Gln Glu Asp Asp Glu Glu Glu
465                 470                 475                 480 
Asp Glu Glu Glu Glu Ala Ala Ala Gly Lys Asp Gly Asp Lys Ser Pro
                485                 490                 495     
Met Ser Ser Leu Gln Ile Ser Asn Glu Lys Asn Leu Glu Pro Gly Lys
            500                 505                 510         
Gln Ile Ser Arg Ser Ser Gly Glu Gln Gln Asn Lys Gly Arg Ile Val
        515                 520                 525             
Ser Pro Ser Leu Leu Ser Glu Glu Pro Leu Ala Pro Ser Ser Ile Asp
    530                 535                 540                 
Ala Glu Ser Asn Gly Glu Gln Pro Glu Glu Leu Thr Leu Glu Glu Glu
545                 550                 555                 560 
Ser Pro Val Ser Gln Leu Phe Glu Leu Glu Ile Glu Ala Leu Pro Leu
                565                 570                 575     
Asp Thr Pro Ser Ser Val Glu Thr Asp Ile Ser Ser Ser Arg Lys Gln
            580                 585                 590         
Ser Glu Glu Pro Phe Thr Thr Val Leu Glu Asn Gly Ala Gly Met Val
        595                 600                 605             
Ser Ser Thr Ser Phe Asn Gly Gly Val Ser Pro His Asn Trp Gly Asp
    610                 615                 620                 
Ser Gly Pro Pro Cys Lys Lys Ser Arg Lys Glu Lys Lys Gln Thr Gly
625                 630                 635                 640 
Ser Gly Pro Leu Gly Asn Ser Tyr Val Glu Arg Gln Arg Ser Val His
                645                 650                 655     
Glu Lys Asn Gly Lys Lys Ile Cys Thr Leu Pro Ser Pro Pro Ser Pro
            660                 665                 670         
Leu Ala Ser Leu Ala Pro Val Ala Asp Ser Ser Thr Arg Val Asp Ser
        675                 680                 685             
Pro Ser His Gly Leu Val Thr Ser Ser Leu Cys Ile Pro Ser Pro Ala
    690                 695                 700                 
Arg Leu Ser Gln Thr Pro His Ser Gln Pro Pro Arg Pro Gly Thr Cys
705                 710                 715                 720 
Lys Thr Ser Val Ala Thr Gln Cys Asp Pro Glu Glu Ile Ile Val Leu
                725                 730                 735     
Ser Asp Ser Asp
            740 


<210> 1281
<211> 359
<212> PRT
<213> Homo sapiens

<400> 1281
Met Asp Glu Gln Asp Leu Asn Glu Pro Leu Ala Lys Val Ser Leu Leu
 1               5                  10                  15      
Lys Asp Asp Leu Gln Gly Ala Gln Ser Glu Thr Glu Ala Lys Gln Glu
            20                  25                  30          
Ile Gln His Leu Arg Lys Glu Leu Ile Glu Ala Gln Glu Leu Ala Arg
        35                  40                  45              
Ala Ser Lys Gln Lys Cys Phe Glu Leu Gln Ala Leu Leu Glu Glu Glu
    50                  55                  60                  
Arg Lys Ala Tyr Arg Asn Gln Val Glu Glu Ser Thr Lys Gln Ile Gln
65                  70                  75                  80  
Val Leu Gln Ala Gln Leu Gln Arg Leu His Ile Asp Thr Glu Asn Leu
                85                  90                  95      
Arg Glu Glu Lys Asp Ser Glu Ile Thr Ser Thr Arg Asp Glu Leu Leu
            100                 105                 110         
Ser Ala Arg Asp Glu Ile Leu Leu Leu His Gln Ala Ala Ala Lys Val
        115                 120                 125             
Ala Ser Glu Arg Asp Thr Asp Ile Ala Ser Leu Gln Glu Glu Leu Lys
    130                 135                 140                 
Lys Val Arg Ala Glu Leu Glu Arg Trp Arg Lys Ala Ala Ser Glu Tyr
145                 150                 155                 160 
Glu Lys Glu Ile Thr Ser Leu Gln Asn Ser Phe Gln Leu Arg Cys Gln
                165                 170                 175     
Gln Cys Glu Asp Gln Gln Arg Glu Glu Ala Thr Arg Leu Gln Gly Glu
            180                 185                 190         
Leu Glu Lys Leu Arg Lys Glu Trp Asn Ala Leu Glu Thr Glu Cys His
        195                 200                 205             
Ser Leu Lys Arg Glu Asn Val Leu Leu Ser Ser Glu Leu Gln Arg Gln
    210                 215                 220                 
Glu Lys Glu Leu His Asn Ser Gln Lys Gln Ser Leu Glu Leu Thr Ser
225                 230                 235                 240 
Asp Leu Ser Ile Leu Gln Met Ser Arg Lys Glu Leu Glu Asn Gln Val
                245                 250                 255     
Gly Ser Leu Lys Glu Gln His Leu Arg Asp Ser Ala Asp Leu Lys Thr
            260                 265                 270         
Leu Leu Ser Lys Ala Glu Asn Gln Ala Lys Asp Val Gln Lys Glu Tyr
        275                 280                 285             
Glu Lys Thr Gln Thr Val Leu Ser Glu Leu Lys Leu Lys Phe Glu Met
    290                 295                 300                 
Thr Glu Gln Glu Lys Gln Ser Ile Thr Asp Glu Leu Lys Gln Cys Lys
305                 310                 315                 320 
Asn Asn Leu Lys Leu Leu Arg Glu Lys Gly Asn Asn Pro Ser Ile Leu
                325                 330                 335     
Gln Pro Val Pro Ala Val Phe Ile Gly Leu Phe Leu Ala Phe Leu Phe
            340                 345                 350         
Trp Cys Phe Gly Pro Leu Trp
        355                 


<210> 1282
<211> 392
<212> PRT
<213> Homo sapiens

<400> 1282
Met Asp Ala Leu Val Glu Asp Asp Ile Cys Ile Leu Asn His Glu Lys
 1               5                  10                  15      
Ala His Lys Arg Asp Thr Val Thr Pro Val Ser Ile Tyr Ser Gly Asp
            20                  25                  30          
Glu Ser Val Ala Ser His Phe Ala Leu Val Thr Ala Tyr Glu Asp Ile
        35                  40                  45              
Lys Lys Arg Leu Lys Asp Ser Glu Lys Glu Asn Ser Leu Leu Lys Lys
    50                  55                  60                  
Arg Ile Arg Phe Leu Glu Glu Lys Leu Ile Ala Arg Phe Glu Glu Glu
65                  70                  75                  80  
Thr Ser Ser Val Gly Arg Glu Gln Val Asn Lys Ala Tyr His Ala Tyr
                85                  90                  95      
Arg Glu Val Cys Ile Asp Arg Asp Asn Leu Lys Ser Lys Leu Asp Lys
            100                 105                 110         
Met Asn Lys Asp Asn Ser Glu Ser Leu Lys Val Leu Asn Glu Gln Leu
        115                 120                 125             
Gln Ser Lys Glu Val Glu Leu Leu Gln Leu Arg Thr Glu Val Glu Thr
    130                 135                 140                 
Gln Gln Val Met Arg Asn Leu Asn Pro Pro Ser Ser Asn Trp Glu Val
145                 150                 155                 160 
Glu Lys Leu Ser Cys Asp Leu Lys Ile His Gly Leu Glu Gln Glu Leu
                165                 170                 175     
Glu Leu Met Arg Lys Glu Cys Ser Asp Leu Lys Ile Glu Leu Gln Lys
            180                 185                 190         
Ala Lys Gln Thr Asp Pro Tyr Gln Glu Asp Asn Leu Lys Ser Arg Asp
        195                 200                 205             
Leu Gln Lys Leu Ser Ile Ser Ser Asp Asn Met Gln His Ala Tyr Trp
    210                 215                 220                 
Glu Leu Lys Arg Glu Met Ser Asn Leu His Leu Val Thr Gln Val Gln
225                 230                 235                 240 
Ala Glu Leu Leu Arg Lys Leu Lys Thr Ser Thr Ala Ile Lys Lys Ala
                245                 250                 255     
Cys Ala Pro Val Gly Cys Ser Glu Asp Leu Gly Arg Asp Ser Thr Lys
            260                 265                 270         
Leu His Leu Met Asn Phe Thr Ala Thr Tyr Thr Arg His Pro Pro Leu
        275                 280                 285             
Leu Pro Asn Gly Lys Ala Leu Cys His Thr Thr Ser Ser Pro Leu Pro
    290                 295                 300                 
Gly Asp Val Lys Val Leu Ser Glu Lys Ala Ile Leu Gln Ser Trp Thr
305                 310                 315                 320 
Asp Asn Glu Arg Ser Ile Pro Asn Asp Gly Thr Cys Phe Gln Glu His
                325                 330                 335     
Ser Ser Tyr Gly Arg Asn Ser Leu Glu Asp Asn Ser Trp Val Phe Pro
            340                 345                 350         
Ser Pro Pro Lys Ser Ser Glu Thr Ala Phe Gly Glu Thr Lys Thr Lys
        355                 360                 365             
Thr Leu Pro Leu Pro Asn Leu Pro Pro Leu His Tyr Leu Asp Gln His
    370                 375                 380                 
Asn Gln Asn Cys Leu Tyr Lys Asn
385                 390         


<210> 1283
<211> 2161
<212> PRT
<213> Homo sapiens

<400> 1283
Met Thr His Ser Pro Ala Thr Ser Glu Asp Glu Glu Arg His Ser Ala
 1               5                  10                  15      
Ser Glu Cys Pro Glu Gly Gly Ser Glu Ser Asp Ser Ser Pro Asp Gly
            20                  25                  30          
Pro Gly Arg Gly Pro Arg Gly Thr Arg Gly Gln Gly Ser Gly Ala Pro
        35                  40                  45              
Gly Ser Leu Ala Ser Val Arg Gly Leu Gln Gly Arg Ser Met Ser Val
    50                  55                  60                  
Pro Asp Asp Ala His Phe Ser Met Met Val Phe Arg Ile Gly Ile Pro
65                  70                  75                  80  
Asp Leu His Gln Thr Lys Cys Leu Arg Phe Asn Pro Asp Ala Thr Ile
                85                  90                  95      
Trp Thr Ala Lys Gln Gln Val Leu Cys Ala Leu Ser Glu Ser Leu Gln
            100                 105                 110         
Asp Val Leu Asn Tyr Gly Leu Phe Gln Pro Ala Thr Ser Gly Arg Asp
        115                 120                 125             
Ala Asn Phe Leu Glu Glu Glu Arg Leu Leu Arg Glu Tyr Pro Gln Ser
    130                 135                 140                 
Phe Glu Lys Gly Val Pro Tyr Leu Glu Phe Arg Tyr Lys Thr Arg Val
145                 150                 155                 160 
Tyr Lys Gln Thr Asn Leu Asp Glu Lys Gln Leu Ala Lys Leu His Thr
                165                 170                 175     
Lys Thr Gly Leu Lys Lys Phe Leu Glu Tyr Val Gln Leu Gly Thr Ser
            180                 185                 190         
Asp Lys Val Ala Arg Leu Leu Asp Lys Gly Leu Asp Pro Asn Tyr His
        195                 200                 205             
Asp Ser Asp Ser Gly Glu Thr Pro Leu Thr Leu Ala Ala Gln Thr Glu
    210                 215                 220                 
Gly Ser Val Glu Val Ile Arg Thr Leu Cys Leu Gly Gly Ala His Ile
225                 230                 235                 240 
Asp Phe Arg Ala Arg Asp Gly Met Thr Ala Leu His Lys Ala Ala Cys
                245                 250                 255     
Ala Arg His Cys Leu Ala Leu Thr Ala Leu Leu Asp Leu Gly Gly Ser
            260                 265                 270         
Pro Asn Tyr Lys Asp Arg Arg Gly Leu Thr Pro Leu Phe His Thr Ala
        275                 280                 285             
Met Val Gly Gly Asp Pro Arg Cys Cys Glu Leu Leu Leu Phe Asn Arg
    290                 295                 300                 
Ala Gln Leu Gly Ile Ala Asp Glu Asn Gly Trp Gln Glu Ile His Gln
305                 310                 315                 320 
Ala Cys Gln Arg Gly His Ser Gln His Leu Glu His Leu Leu Phe Tyr
                325                 330                 335     
Gly Ala Glu Pro Gly Ala Gln Asn Ala Ser Gly Asn Thr Ala Leu His
            340                 345                 350         
Ile Cys Ala Leu Tyr Asn Lys Glu Thr Cys Ala Arg Ile Leu Leu Tyr
        355                 360                 365             
Arg Gly Ala Asp Lys Asp Val Lys Asn Asn Asn Gly Gln Thr Pro Phe
    370                 375                 380                 
Gln Val Ala Val Ile Ala Gly Asn Phe Glu Leu Gly Glu Leu Ile Arg
385                 390                 395                 400 
Asn His Arg Glu Gln Asp Val Val Pro Phe Gln Glu Ser Pro Lys Tyr
                405                 410                 415     
Ala Ala Arg Arg Arg Gly Pro Pro Gly Thr Gly Leu Thr Val Pro Pro
            420                 425                 430         
Ala Leu Leu Arg Ala Asn Ser Asp Thr Ser Met Ala Leu Pro Asp Trp
        435                 440                 445             
Met Val Phe Ser Ala Pro Gly Ala Ala Ser Ser Gly Ala Pro Gly Pro
    450                 455                 460                 
Thr Ser Gly Ser Gln Gly Gln Ser Gln Pro Ser Ala Pro Thr Thr Lys
465                 470                 475                 480 
Leu Ser Ser Gly Thr Leu Arg Ser Ala Ser Ser Pro Arg Gly Ala Arg
                485                 490                 495     
Ala Arg Ser Pro Ser Arg Gly Arg His Pro Glu Asp Ala Lys Arg Gln
            500                 505                 510         
Pro Arg Gly Arg Pro Ser Ser Ser Gly Thr Pro Arg Glu Gly Pro Ala
        515                 520                 525             
Gly Gly Thr Gly Gly Ser Gly Gly Pro Gly Gly Ser Leu Gly Ser Arg
    530                 535                 540                 
Gly Arg Arg Arg Lys Leu Tyr Ser Ala Val Pro Gly Arg Ser Phe Met
545                 550                 555                 560 
Ala Val Lys Ser Tyr Gln Ala Gln Ala Glu Gly Glu Ile Ser Leu Ser
                565                 570                 575     
Lys Gly Glu Lys Ile Lys Val Leu Ser Ile Gly Glu Gly Gly Phe Trp
            580                 585                 590         
Glu Gly Gln Val Lys Gly Arg Val Gly Trp Phe Pro Ser Asp Cys Leu
        595                 600                 605             
Glu Glu Val Ala Asn Arg Ser Gln Glu Ser Lys Gln Glu Ser Arg Ser
    610                 615                 620                 
Asp Lys Ala Lys Arg Leu Phe Arg His Tyr Thr Val Gly Ser Tyr Asp
625                 630                 635                 640 
Ser Phe Asp Ala Pro Ser Leu Met Asp Gly Ile Gly Pro Gly Ser Asp
                645                 650                 655     
Tyr Ile Ile Lys Glu Lys Thr Val Leu Leu Gln Lys Lys Asp Ser Glu
            660                 665                 670         
Gly Phe Gly Phe Val Leu Arg Gly Ala Lys Ala Gln Thr Pro Ile Glu
        675                 680                 685             
Glu Phe Thr Pro Thr Pro Ala Phe Pro Ala Leu Gln Tyr Leu Glu Ser
    690                 695                 700                 
Val Asp Glu Gly Gly Val Ala Trp Arg Ala Gly Leu Arg Met Gly Asp
705                 710                 715                 720 
Phe Leu Ile Glu Val Asn Gly Gln Asn Val Val Lys Val Gly His Arg
                725                 730                 735     
Gln Val Val Asn Met Ile Arg Gln Gly Gly Asn Thr Leu Met Val Lys
            740                 745                 750         
Val Val Met Val Thr Arg His Pro Asp Met Asp Glu Ala Val His Lys
        755                 760                 765             
Lys Ala Pro Gln Gln Ala Lys Arg Leu Pro Pro Pro Thr Ile Ser Leu
    770                 775                 780                 
Arg Ser Lys Ser Met Thr Ser Glu Leu Glu Glu Met Glu Tyr Glu Gln
785                 790                 795                 800 
Gln Pro Ala Pro Val Pro Ser Met Glu Lys Lys Arg Thr Val Tyr Gln
                805                 810                 815     
Met Ala Leu Asn Lys Leu Asp Glu Ile Leu Ala Ala Ala Gln Gln Thr
            820                 825                 830         
Ile Ser Ala Ser Glu Ser Pro Gly Pro Gly Gly Leu Ala Ser Leu Gly
        835                 840                 845             
Lys His Arg Pro Lys Gly Phe Phe Ala Thr Glu Ser Ser Phe Asp Pro
    850                 855                 860                 
His His Arg Ala Gln Pro Ser Tyr Glu Arg Pro Ser Phe Leu Pro Pro
865                 870                 875                 880 
Gly Pro Gly Leu Met Leu Arg Gln Lys Ser Ile Gly Ala Ala Glu Asp
                885                 890                 895     
Asp Arg Pro Tyr Leu Ala Pro Pro Ala Met Lys Phe Ser Arg Ser Leu
            900                 905                 910         
Ser Val Pro Gly Ser Glu Asp Ile Pro Pro Pro Pro Thr Thr Tyr Pro
        915                 920                 925             
Pro Glu Pro Pro Tyr Ser Thr Pro Thr Val Pro Ser Ser Ser Gly Arg
    930                 935                 940                 
Leu Thr Pro Ser Pro Arg Gly Gly Pro Phe Asn Pro Gly Ser Gly Gly
945                 950                 955                 960 
Pro Leu Pro Ala Ser Ser Pro Ala Thr Phe Asp Gly Pro Ser Pro Pro
                965                 970                 975     
Asp Thr Arg Val Gly Ser Arg Glu Lys Ser Leu Tyr His Ser Gly Pro
            980                 985                 990         
Leu Pro Pro Ala His His His Pro Pro His His His His His His Ala
        995                 1000                1005            
Pro Pro Pro Gln Pro His His His His Ala His Pro Pro His Pro Pro
    1010                1015                1020                
Glu Met Glu Thr Gly Gly Ser Pro Asp Asp Pro Pro Pro Arg Leu Ala
1025                1030                1035                1040
Leu Gly Pro Gln Pro Ser Leu Arg Gly Trp Arg Gly Gly Gly Pro Ser
                1045                1050                1055    
Pro Thr Pro Gly Ala Pro Ser Pro Ser His His Gly Ser Ala Gly Gly
            1060                1065                1070        
Gly Gly Gly Ser Ser Gln Gly Pro Ala Leu Arg Tyr Ile Gln Leu Pro
        1075                1080                1085            
Pro Arg Ala Ala Ser Ala Ala Met Tyr Val Pro Ala Arg Ser Gly Arg
    1090                1095                1100                
Gly Arg Lys Gly Pro Leu Val Lys Gln Thr Lys Val Glu Gly Glu Pro
1105                1110                1115                1120
Gln Lys Gly Gly Gly Leu Pro Pro Ala Pro Ser Pro Ser Ser Pro Ala
                1125                1130                1135    
Ser Pro Gln Pro Pro Pro Ala Val Ala Ala Pro Ser Glu Lys Asn Ser
            1140                1145                1150        
Ile Pro Ile Pro Thr Ile Ile Ile Lys Ala Pro Ser Thr Ser Ser Ser
        1155                1160                1165            
Gly Arg Ser Ser Gln Gly Ser Ser Thr Glu Ala Glu Pro Pro Thr Gln
    1170                1175                1180                
Pro Glu Pro Thr Gly Gly Gly Gly Gly Gly Gly Ser Ser Pro Ser Pro
1185                1190                1195                1200
Ala Pro Ala Met Ser Pro Val Pro Pro Ser Pro Ser Pro Val Pro Thr
                1205                1210                1215    
Pro Ala Ser Pro Ser Gly Pro Ala Thr Leu Asp Phe Thr Ser Gln Phe
            1220                1225                1230        
Gly Ala Ala Leu Val Gly Ala Ala Arg Arg Glu Gly Gly Trp Gln Asn
        1235                1240                1245            
Glu Ala Arg Arg Arg Ser Thr Leu Phe Leu Ser Thr Asp Ala Gly Asp
    1250                1255                1260                
Glu Asp Gly Gly Asp Gly Gly Leu Gly Thr Gly Ala Ala Pro Gly Pro
1265                1270                1275                1280
Arg Leu Arg His Ser Lys Ser Ile Asp Glu Gly Met Phe Ser Ala Glu
                1285                1290                1295    
Pro Tyr Leu Arg Leu Glu Ser Ala Gly Ser Gly Ala Gly Tyr Gly Gly
            1300                1305                1310        
Tyr Gly Ala Gly Ser Arg Ala Tyr Gly Gly Gly Gly Gly Ser Ser Ala
        1315                1320                1325            
Phe Thr Ser Phe Leu Pro Pro Arg Pro Leu Val His Pro Leu Thr Gly
    1330                1335                1340                
Lys Ala Leu Asp Pro Ala Ser Pro Leu Gly Leu Ala Leu Ala Ala Arg
1345                1350                1355                1360
Glu Arg Ala Leu Lys Glu Ser Ser Glu Gly Gly Gly Ala Pro Gln Pro
                1365                1370                1375    
Pro Pro Arg Pro Pro Ser Pro Arg Tyr Glu Ala Pro Pro Pro Thr Pro
            1380                1385                1390        
His His His Ser Pro His Ala His His Glu Pro Val Leu Arg Leu Trp
        1395                1400                1405            
Gly Ala Ser Pro Pro Asp Pro Ala Arg Arg Glu Leu Gly Tyr Arg Ala
    1410                1415                1420                
Gly Leu Gly Ser Gln Glu Lys Ser Leu Pro Ala Ser Pro Pro Ala Ala
1425                1430                1435                1440
Arg Arg Ser Leu Leu His Arg Leu Pro Pro Thr Ala Pro Gly Val Gly
                1445                1450                1455    
Pro Leu Leu Leu Gln Leu Gly Thr Glu Pro Pro Ala Pro His Pro Gly
            1460                1465                1470        
Val Ser Lys Pro Trp Arg Ser Ala Ala Pro Glu Glu Pro Glu Arg Leu
        1475                1480                1485            
Pro Leu His Val Arg Phe Leu Glu Asn Cys Gln Pro Arg Ala Pro Val
    1490                1495                1500                
Thr Ser Gly Arg Gly Pro Pro Ser Glu Asp Gly Pro Gly Val Pro Pro
1505                1510                1515                1520
Pro Ser Pro Arg Arg Ser Val Pro Pro Ser Pro Thr Ser Pro Arg Ala
                1525                1530                1535    
Ser Glu Glu Asn Gly Leu Pro Leu Leu Val Leu Pro Pro Pro Ala Pro
            1540                1545                1550        
Ser Val Asp Val Glu Asp Gly Glu Phe Leu Phe Val Glu Pro Leu Pro
        1555                1560                1565            
Pro Pro Leu Glu Phe Ser Asn Ser Phe Glu Lys Pro Glu Ser Pro Leu
    1570                1575                1580                
Thr Pro Gly Pro Pro His Pro Leu Pro Asp Thr Pro Ala Pro Ala Thr
1585                1590                1595                1600
Pro Leu Pro Pro Val Pro Pro Pro Ala Val Ala Ala Ala Pro Pro Thr
                1605                1610                1615    
Leu Asp Ser Thr Ala Ser Ser Leu Thr Ser Tyr Asp Ser Glu Val Ala
            1620                1625                1630        
Thr Leu Thr Gln Gly Ala Ser Ala Ala Pro Gly Asp Pro His Pro Pro
        1635                1640                1645            
Gly Pro Pro Ala Pro Ala Ala Pro Ala Pro Ala Ala Pro Gln Pro Gly
    1650                1655                1660                
Pro Asp Pro Pro Pro Gly Thr Asp Ser Gly Ile Glu Glu Val Asp Ser
1665                1670                1675                1680
Arg Ser Ser Ser Asp His Pro Leu Glu Thr Ile Ser Ser Ala Ser Thr
                1685                1690                1695    
Leu Ser Ser Leu Ser Ala Glu Gly Gly Gly Ser Ala Gly Gly Gly Gly
            1700                1705                1710        
Gly Ala Gly Ala Gly Val Ala Ser Gly Pro Glu Leu Leu Asp Thr Tyr
        1715                1720                1725            
Val Ala Tyr Leu Asp Gly Gln Ala Phe Gly Gly Ser Ser Thr Pro Gly
    1730                1735                1740                
Pro Pro Tyr Pro Pro Gln Leu Met Thr Pro Ser Lys Leu Arg Gly Arg
1745                1750                1755                1760
Ala Leu Gly Ala Ser Gly Gly Leu Arg Pro Gly Pro Ser Gly Gly Leu
                1765                1770                1775    
Arg Asp Pro Val Thr Pro Thr Ser Pro Thr Val Ser Val Thr Gly Ala
            1780                1785                1790        
Gly Thr Asp Gly Leu Leu Ala Leu Arg Ala Cys Ser Gly Pro Pro Thr
        1795                1800                1805            
Ala Gly Val Ala Gly Gly Pro Val Ala Val Glu Pro Glu Val Pro Pro
    1810                1815                1820                
Val Pro Leu Pro Thr Ala Ser Cys Leu Pro Arg Lys Leu Leu Pro Trp
1825                1830                1835                1840
Glu Glu Gly Pro Gly Pro Pro Pro Pro Pro Leu Pro Gly Pro Leu Ala
                1845                1850                1855    
Gln Pro Gln Ala Ser Ala Leu Ala Thr Val Lys Ala Ser Ile Ile Ser
            1860                1865                1870        
Glu Leu Ser Ser Lys Leu Gln Gln Phe Gly Gly Ser Ser Ala Ala Gly
        1875                1880                1885            
Gly Ala Leu Pro Trp Ala Arg Gly Gly Ser Gly Gly Gly Gly Asp Ser
    1890                1895                1900                
His His Gly Gly Ala Ser Tyr Val Pro Glu Arg Thr Ser Ser Leu Gln
1905                1910                1915                1920
Arg Gln Arg Leu Ser Asp Asp Ser Gln Ser Ser Leu Leu Ser Lys Pro
                1925                1930                1935    
Val Ser Ser Leu Phe Gln Asn Trp Pro Lys Pro Pro Leu Pro Pro Leu
            1940                1945                1950        
Pro Thr Gly Thr Gly Val Ser Pro Thr Ala Ala Ala Ala Pro Gly Ala
        1955                1960                1965            
Thr Ser Pro Ser Ala Ser Ser Ser Ser Thr Ser Thr Arg His Leu Gln
    1970                1975                1980                
Gly Val Glu Phe Glu Met Arg Pro Pro Leu Leu Arg Arg Ala Pro Ser
1985                1990                1995                2000
Pro Ser Leu Leu Pro Ala Ser Glu His Lys Val Ser Pro Ala Pro Arg
                2005                2010                2015    
Pro Ser Ser Leu Pro Ile Leu Pro Ser Gly Pro Leu Tyr Pro Gly Leu
            2020                2025                2030        
Phe Asp Ile Arg Gly Ser Pro Thr Gly Gly Ala Gly Gly Ser Ala Asp
        2035                2040                2045            
Pro Phe Ala Pro Val Phe Val Pro Pro His Pro Gly Ile Ser Gly Gly
    2050                2055                2060                
Leu Gly Gly Ala Leu Ser Gly Ala Ser Arg Ser Leu Ser Pro Thr Arg
2065                2070                2075                2080
Leu Leu Ser Leu Pro Pro Asp Lys Pro Phe Gly Ala Lys Pro Leu Gly
                2085                2090                2095    
Phe Trp Thr Lys Phe Asp Val Ala Asp Trp Leu Glu Trp Leu Gly Leu
            2100                2105                2110        
Ala Glu His Arg Ala Gln Phe Leu Asp His Glu Ile Asp Gly Ser His
        2115                2120                2125            
Leu Pro Ala Leu Thr Lys Glu Asp Tyr Val Asp Leu Gly Val Thr Arg
    2130                2135                2140                
Val Gly His Arg Met Asn Ile Asp Arg Ala Leu Lys Phe Phe Leu Glu
2145                2150                2155                2160
Arg
    


<210> 1284
<211> 417
<212> PRT
<213> Homo sapiens

<400> 1284
Met Ser Leu Ser Lys Lys Leu Thr Leu Asp Lys Leu Asp Val Arg Gly
 1               5                  10                  15      
Lys Arg Val Ile Met Arg Val Asp Phe Asn Val Pro Met Lys Lys Asn
            20                  25                  30          
Gln Ile Thr Asn Asn Gln Arg Ile Lys Ala Ser Ile Pro Ser Ile Lys
        35                  40                  45              
Tyr Cys Leu Asp Asn Gly Ala Lys Ala Val Val Leu Met Ser His Leu
    50                  55                  60                  
Gly Arg Pro Asp Gly Val Pro Met Pro Asp Lys Tyr Ser Leu Ala Pro
65                  70                  75                  80  
Val Ala Val Glu Leu Lys Ser Leu Leu Gly Lys Asp Val Leu Phe Leu
                85                  90                  95      
Lys Asp Cys Val Gly Ala Glu Val Glu Lys Ala Cys Ala Asn Pro Ala
            100                 105                 110         
Pro Gly Ser Val Ile Leu Leu Glu Asn Leu Arg Phe His Val Glu Glu
        115                 120                 125             
Glu Gly Lys Gly Gln Asp Pro Ser Gly Lys Lys Ile Lys Ala Glu Pro
    130                 135                 140                 
Asp Lys Ile Glu Ala Phe Arg Ala Ser Leu Ser Lys Leu Gly Asp Val
145                 150                 155                 160 
Tyr Val Asn Asp Ala Phe Gly Thr Ala His Arg Ala His Ser Ser Met
                165                 170                 175     
Val Gly Val Asn Leu Pro His Lys Ala Ser Gly Phe Leu Met Lys Lys
            180                 185                 190         
Glu Leu Asp Tyr Phe Ala Lys Ala Leu Glu Asn Pro Val Arg Pro Phe
        195                 200                 205             
Leu Ala Ile Leu Gly Gly Ala Lys Val Ala Asp Lys Ile Gln Leu Ile
    210                 215                 220                 
Lys Asn Met Leu Asp Lys Val Asn Glu Met Ile Ile Gly Gly Gly Met
225                 230                 235                 240 
Ala Tyr Thr Phe Leu Lys Val Leu Asn Asn Met Glu Ile Gly Ala Ser
                245                 250                 255     
Leu Phe Asp Glu Glu Gly Ala Lys Ile Val Lys Asp Ile Met Ala Lys
            260                 265                 270         
Ala Gln Lys Asn Gly Val Arg Ile Thr Phe Pro Val Asp Phe Val Thr
        275                 280                 285             
Gly Asp Lys Phe Asp Glu Asn Ala Gln Val Gly Lys Ala Thr Val Ala
    290                 295                 300                 
Ser Gly Ile Ser Pro Gly Trp Met Gly Leu Asp Cys Gly Pro Glu Ser
305                 310                 315                 320 
Asn Lys Asn His Ala Gln Val Val Ala Gln Ala Arg Leu Ile Val Trp
                325                 330                 335     
Asn Gly Pro Leu Gly Val Phe Glu Trp Asp Ala Phe Ala Lys Gly Thr
            340                 345                 350         
Lys Ala Leu Met Asp Glu Ile Val Lys Ala Thr Ser Lys Gly Cys Ile
        355                 360                 365             
Thr Val Ile Gly Gly Gly Asp Thr Ala Thr Cys Cys Ala Lys Trp Asn
    370                 375                 380                 
Thr Glu Asp Lys Val Ser His Val Ser Thr Gly Gly Gly Ala Ser Leu
385                 390                 395                 400 
Glu Leu Leu Glu Gly Lys Ile Leu Pro Gly Val Glu Ala Leu Ser Asn
                405                 410                 415     
Met
    


<210> 1285
<211> 316
<212> PRT
<213> Homo sapiens

<400> 1285
Met Pro Thr Phe Asn Gly Ser Val Phe Met Pro Ser Ala Phe Ile Leu
 1               5                  10                  15      
Ile Gly Ile Pro Gly Leu Glu Ser Val Gln Cys Trp Ile Gly Ile Pro
            20                  25                  30          
Phe Ser Ala Met Tyr Leu Ile Gly Val Ile Gly Asn Ser Leu Ile Leu
        35                  40                  45              
Val Ile Ile Lys Tyr Glu Asn Ser Leu His Ile Pro Met Tyr Ile Phe
    50                  55                  60                  
Leu Ala Met Leu Ala Ala Thr Asp Ile Ala Leu Asn Thr Cys Ile Leu
65                  70                  75                  80  
Pro Lys Met Leu Gly Ile Phe Trp Phe His Leu Pro Glu Ile Ser Phe
                85                  90                  95      
Asp Ala Cys Leu Phe Gln Met Trp Leu Ile His Ser Phe Gln Ala Ile
            100                 105                 110         
Glu Ser Gly Ile Leu Leu Ala Met Ala Leu Asp Arg Tyr Val Ala Ile
        115                 120                 125             
Cys Ile Pro Leu Arg His Ala Thr Ile Phe Ser Gln Gln Phe Leu Thr
    130                 135                 140                 
His Ile Gly Leu Gly Val Thr Leu Arg Ala Ala Ile Leu Ile Ile Pro
145                 150                 155                 160 
Ser Leu Gly Leu Ile Lys Cys Cys Leu Lys His Tyr Arg Thr Thr Val
                165                 170                 175     
Ile Ser His Ser Tyr Cys Glu His Met Ala Ile Val Lys Leu Ala Thr
            180                 185                 190         
Glu Asp Ile Arg Val Asn Lys Ile Tyr Gly Leu Phe Val Ala Phe Ala
        195                 200                 205             
Ile Leu Gly Phe Asp Ile Ile Phe Ile Thr Leu Ser Tyr Val Gln Ile
    210                 215                 220                 
Phe Ile Thr Val Phe Gln Leu Pro Gln Lys Glu Ala Arg Phe Lys Ala
225                 230                 235                 240 
Phe Asn Thr Cys Ile Ala His Ile Cys Val Phe Leu Gln Phe Tyr Leu
                245                 250                 255     
Leu Ala Phe Phe Ser Phe Phe Thr His Arg Phe Gly Ser His Ile Pro
            260                 265                 270         
Pro Tyr Ile His Ile Leu Leu Ser Asn Leu Tyr Leu Leu Val Pro Pro
        275                 280                 285             
Phe Leu Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile Arg Asp
    290                 295                 300                 
His Ile Val Lys Val Phe Phe Phe Lys Lys Val Thr
305                 310                 315     


<210> 1286
<211> 161
<212> PRT
<213> Homo sapiens

<400> 1286
Met Leu Ala Asp Gln Pro Arg Thr Thr Lys Tyr His Ser Val Ile Leu
 1               5                  10                  15      
Gln Asn Lys Glu Ser Leu Arg Ile Lys Ser Ser Trp Thr Trp Ala Val
            20                  25                  30          
Gly Leu Gly Ser Ser Val Ser Ser Val His Thr Met Arg Gly Leu Glu
        35                  40                  45              
Ala Val Tyr Ala Val Glu Ala Ser Glu Met Ala Gln His Thr Gly Gln
    50                  55                  60                  
Leu Val Leu Gln Asn Gly Phe Ala Asp Ile Ile Thr Val Tyr Gln Gln
65                  70                  75                  80  
Lys Val Lys Asp Val Val Leu Pro Glu Lys Val Asp Val Leu Val Ser
                85                  90                  95      
Glu Trp Met Gly Thr Cys Leu Leu Phe Glu Phe Met Ile Glu Ser Ile
            100                 105                 110         
Leu Tyr Ala Arg Asp Ala Trp Leu Lys Glu Thr Gly Ser Phe Gly Pro
        115                 120                 125             
Pro Trp Leu Arg Cys Thr Leu Cys Pro Ala Val Leu Ile Arg Ile Ile
    130                 135                 140                 
Val Ala Arg Cys Ser Ser Gly Thr Thr Arg Thr Ser Ser Thr Ser Ala
145                 150                 155                 160 
Leu
    


<210> 1287
<211> 76
<212> PRT
<213> Homo sapiens

<400> 1287
Met Ser Glu Pro Gln Pro Arg Gly Ala Glu Arg Asp Leu Tyr Arg Asp
 1               5                  10                  15      
Thr Trp Val Arg Tyr Leu Gly Tyr Ala Asn Glu Val Gly Glu Ala Phe
            20                  25                  30          
Arg Ser Leu Val Pro Ala Ala Val Val Trp Leu Ser Tyr Gly Val Ala
        35                  40                  45              
Ser Ser Tyr Val Leu Ala Asp Ala Ile Asp Lys Gly Lys Lys Ala Gly
    50                  55                  60                  
Glu Cys Pro Ala Leu Lys Gln Ala Ala Ala Pro Gly
65                  70                  75      


<210> 1288
<211> 180
<212> PRT
<213> Homo sapiens

<400> 1288
Met Phe Lys Val Ile Gln Arg Ser Val Gly Pro Ala Ser Leu Ser Leu
 1               5                  10                  15      
Leu Thr Phe Lys Val Tyr Ala Ala Pro Lys Lys Asp Ser Pro Pro Lys
            20                  25                  30          
Asn Ser Val Lys Val Asp Glu Leu Ser Leu Tyr Ser Val Pro Glu Gly
        35                  40                  45              
Gln Ser Lys Tyr Val Glu Glu Ala Arg Ser Gln Leu Glu Glu Ser Ile
    50                  55                  60                  
Ser Gln Leu Arg His Tyr Cys Glu Pro Tyr Thr Thr Trp Cys Gln Thr
65                  70                  75                  80  
Ala Met Thr Ile Ser Lys Met His Leu Leu Asp Phe Phe Pro Arg Leu
                85                  90                  95      
Gly Val Ile Gly Phe Ala Gly Leu Ile Gly Leu Leu Leu Ala Arg Gly
            100                 105                 110         
Ser Lys Ile Lys Lys Leu Val Tyr Pro Pro Gly Phe Met Gly Leu Ala
        115                 120                 125             
Ala Ser Leu Tyr Tyr Pro Gln Gln Ala Ile Val Phe Ala Gln Val Ser
    130                 135                 140                 
Gly Glu Arg Leu Tyr Asp Trp Gly Leu Arg Gly Tyr Ile Val Ile Glu
145                 150                 155                 160 
Asp Leu Trp Lys Glu Asn Phe Gln Lys Pro Gly Asn Val Lys Asn Ser
                165                 170                 175     
Pro Gly Thr Lys
            180 


<210> 1289
<211> 168
<212> PRT
<213> Homo sapiens

<400> 1289
Met Ala Pro Leu Gly Thr Thr Val Leu Leu Trp Ser Leu Leu Arg Ser
 1               5                  10                  15      
Ser Pro Gly Val Glu Arg Val Cys Phe Arg Ala Arg Ile Gln Pro Trp
            20                  25                  30          
His Gly Gly Leu Leu Gln Pro Leu Pro Cys Ser Phe Glu Met Gly Leu
        35                  40                  45              
Pro Arg Arg Arg Phe Ser Ser Glu Ala Glu Ser Gly Ser Pro Glu Thr
    50                  55                  60                  
Lys Lys Pro Thr Phe Met Asp Glu Glu Val Gln Ser Ile Leu Thr Lys
65                  70                  75                  80  
Met Thr Gly Leu Asn Leu Gln Lys Thr Phe Lys Pro Ala Ile Gln Glu
                85                  90                  95      
Leu Lys Pro Pro Thr Tyr Lys Leu Met Thr Gln Ala Gln Leu Glu Glu
            100                 105                 110         
Ala Thr Arg Gln Ala Val Glu Ala Ala Lys Val Arg Leu Lys Met Pro
        115                 120                 125             
Pro Val Leu Glu Glu Arg Val Pro Ile Asn Asp Val Leu Ala Glu Asp
    130                 135                 140                 
Lys Ile Leu Glu Gly Thr Glu Thr Thr Lys Tyr Val Phe Thr Asp Ile
145                 150                 155                 160 
Ser Tyr Ser Ile Pro His Arg Cys
                165             


<210> 1290
<211> 227
<212> PRT
<213> Homo sapiens

<400> 1290
Met Glu Lys Leu Phe Asn Glu Asn Glu Gly Met Pro Ser Asn Gln Gly
 1               5                  10                  15      
Lys Ile Asp Asn Glu Glu Gln Pro Pro His Glu Gly Lys Pro Glu Val
            20                  25                  30          
Ala Cys Ile Leu Glu Asp Lys Lys Leu Glu Asn Glu Gly Asn Thr Glu
        35                  40                  45              
Asn Thr Gly Lys Arg Val Glu Glu Pro Leu Lys Asp Lys Glu Lys Pro
    50                  55                  60                  
Glu Ser Ala Gly Lys Ala Lys Gly Glu Gly Lys Ser Glu Arg Lys Gly
65                  70                  75                  80  
Lys Ser Glu Met Gln Gly Gly Ser Lys Thr Glu Gly Lys Pro Glu Arg
                85                  90                  95      
Gly Gly Arg Ala Glu Gly Glu Gly Glu Pro Asp Ser Glu Arg Glu Pro
            100                 105                 110         
Glu Ser Glu Gly Glu Pro Glu Ser Glu Thr Arg Ala Ala Gly Lys Arg
        115                 120                 125             
Pro Ala Glu Asp Asp Ile Pro Arg Lys Ala Lys Arg Lys Thr Asn Lys
    130                 135                 140                 
Gly Leu Ala Gln Tyr Leu Lys Gln Tyr Lys Glu Ala Ile His Asp Met
145                 150                 155                 160 
Asn Phe Ser Asn Glu Asp Met Ile Arg Glu Phe Asp Asn Met Ala Arg
                165                 170                 175     
Val Glu Asp Lys Arg Arg Lys Ser Lys Gln Lys Leu Gly Ala Phe Leu
            180                 185                 190         
Trp Met Gln Arg Asn Leu Gln Asp Pro Phe Tyr Pro Arg Gly Pro Arg
        195                 200                 205             
Glu Phe Arg Gly Gly Cys Arg Ala Pro Arg Arg Asp Thr Glu Asp Ile
    210                 215                 220                 
Pro Tyr Val
225         


<210> 1291
<211> 469
<212> PRT
<213> Homo sapiens

<400> 1291
Met Cys Asp Leu Ile Glu Pro Gln Pro Ala Glu Lys Ile Gly Lys Met
 1               5                  10                  15      
Lys Lys Leu Arg Arg Thr Leu Ser Glu Ser Phe Ser Arg Ile Ala Leu
            20                  25                  30          
Lys Lys Asp Asp Thr Thr Phe Asp Glu Ile Cys Val Thr Lys Met Ser
        35                  40                  45              
Thr Arg Asn Cys Gln Gly Met Asp Ser Val Ile Lys Pro Leu Asp Thr
    50                  55                  60                  
Ile Pro Glu Asp Lys Lys Val Arg Val Gln Arg Thr Gln Ser Thr Phe
65                  70                  75                  80  
Asp Pro Phe Glu Lys Pro Ala Asn Gln Val Lys Arg Val His Ser Glu
                85                  90                  95      
Asn Asn Ala Cys Ile Asn Phe Lys Thr Ser Ser Thr Gly Lys Glu Ser
            100                 105                 110         
Pro Lys Val Arg Arg His Ser Ser Pro Ser Ser Pro Thr Ser Pro Lys
        115                 120                 125             
Phe Gly Lys Ala Asp Ser Tyr Glu Lys Leu Glu Lys Leu Gly Glu Gly
    130                 135                 140                 
Ser Tyr Ala Thr Val Tyr Lys Gly Lys Ser Lys Val Asn Trp Lys Leu
145                 150                 155                 160 
Val Ala Leu Lys Val Ile Arg Leu Gln Glu Glu Glu Gly Thr Pro Phe
                165                 170                 175     
Thr Ala Ile Arg Glu Ala Ser Leu Leu Lys Gly Leu Lys His Ala Asn
            180                 185                 190         
Ile Val Leu Leu His Asp Ile Ile His Thr Lys Glu Thr Leu Thr Leu
        195                 200                 205             
Val Phe Glu Tyr Val His Thr Asp Leu Cys Gln Tyr Met Asp Lys His
    210                 215                 220                 
Pro Gly Gly Leu His Pro Asp Asn Val Lys Leu Phe Leu Phe Gln Leu
225                 230                 235                 240 
Leu Arg Gly Leu Ser Tyr Ile His Gln Arg Tyr Ile Leu His Arg Asp
                245                 250                 255     
Leu Lys Pro Gln Asn Leu Leu Ile Ser Asp Thr Gly Glu Leu Lys Leu
            260                 265                 270         
Ala Asp Phe Gly Leu Ala Arg Ala Lys Ser Val Pro Ser His Thr Tyr
        275                 280                 285             
Ser Asn Glu Val Val Thr Leu Trp Tyr Arg Pro Pro Asp Val Leu Leu
    290                 295                 300                 
Gly Ser Thr Glu Tyr Ser Thr Cys Leu Asp Met Trp Gly Val Gly Cys
305                 310                 315                 320 
Ile Phe Val Glu Met Ile Gln Gly Val Ala Ala Phe Pro Gly Met Lys
                325                 330                 335     
Asp Ile Gln Asp Gln Leu Glu Arg Ile Phe Leu Val Leu Gly Thr Pro
            340                 345                 350         
Asn Glu Asp Thr Trp Pro Gly Val His Ser Leu Pro His Phe Lys Pro
        355                 360                 365             
Glu Arg Phe Thr Leu Tyr Ser Ser Lys Asn Leu Arg Gln Ala Trp Asn
    370                 375                 380                 
Lys Leu Ser Tyr Val Asn His Ala Glu Asp Leu Ala Ser Lys Leu Leu
385                 390                 395                 400 
Gln Cys Ser Pro Lys Asn Arg Leu Ser Ala Gln Ala Ala Leu Ser His
                405                 410                 415     
Glu Tyr Phe Ser Asp Leu Pro Pro Arg Leu Trp Glu Leu Thr Asp Met
            420                 425                 430         
Ser Ser Ile Phe Thr Val Pro Asn Val Arg Leu Gln Pro Glu Ala Gly
        435                 440                 445             
Glu Ser Met Arg Ala Phe Gly Lys Asn Asn Ser Tyr Gly Lys Ser Leu
    450                 455                 460                 
Ser Asn Ser Lys His
465                 


<210> 1292
<211> 539
<212> PRT
<213> Homo sapiens

<400> 1292
Met Gly Phe Glu Glu Leu Leu Glu Gln Val Gly Gly Phe Gly Pro Phe
 1               5                  10                  15      
Gln Leu Arg Asn Val Ala Leu Leu Ala Leu Pro Arg Val Leu Leu Pro
            20                  25                  30          
Leu His Phe Leu Leu Pro Ile Phe Leu Ala Ala Val Pro Ala His Arg
        35                  40                  45              
Cys Ala Leu Pro Gly Ala Pro Ala Asn Phe Ser His Gln Asp Val Trp
    50                  55                  60                  
Leu Glu Ala His Leu Pro Arg Glu Pro Asp Gly Thr Leu Ser Ser Cys
65                  70                  75                  80  
Leu Arg Phe Ala Tyr Pro Gln Ala Leu Pro Asn Thr Thr Leu Gly Glu
                85                  90                  95      
Glu Arg Gln Ser Arg Gly Glu Leu Glu Asp Glu Pro Ala Thr Val Pro
            100                 105                 110         
Cys Ser Gln Gly Trp Glu Tyr Asp His Ser Glu Phe Ser Ser Thr Ile
        115                 120                 125             
Ala Thr Glu Trp Asp Leu Val Cys Glu Gln Lys Gly Leu Asn Arg Ala
    130                 135                 140                 
Ala Ser Thr Phe Phe Phe Ala Gly Val Leu Val Gly Ala Val Ala Phe
145                 150                 155                 160 
Gly Tyr Leu Ser Asp Arg Phe Gly Arg Arg Arg Leu Leu Leu Val Ala
                165                 170                 175     
Tyr Val Ser Thr Leu Val Leu Gly Leu Ala Ser Ala Ala Ser Val Ser
            180                 185                 190         
Tyr Val Met Phe Ala Ile Thr Arg Thr Leu Thr Gly Ser Ala Leu Ala
        195                 200                 205             
Gly Phe Thr Ile Ile Val Met Pro Leu Glu Leu Glu Trp Leu Asp Val
    210                 215                 220                 
Glu His Arg Thr Val Ala Gly Val Leu Ser Ser Thr Phe Trp Thr Gly
225                 230                 235                 240 
Gly Val Met Leu Leu Ala Leu Val Gly Tyr Leu Ile Arg Asp Trp Arg
                245                 250                 255     
Trp Leu Leu Leu Ala Val Thr Leu Pro Cys Ala Pro Gly Ile Leu Ser
            260                 265                 270         
Leu Trp Trp Val Pro Glu Ser Ala Arg Trp Leu Leu Thr Gln Gly His
        275                 280                 285             
Val Lys Glu Ala His Arg Tyr Leu Leu His Cys Ala Arg Pro Asn Gly
    290                 295                 300                 
Arg Pro Val Cys Glu Asp Ser Phe Ser Gln Glu Ala Val Ser Lys Val
305                 310                 315                 320 
Ala Ala Gly Glu Arg Val Val Arg Arg Pro Ser Tyr Leu Asp Leu Phe
                325                 330                 335     
Arg Thr Pro Arg Leu Arg His Ile Ser Leu Cys Cys Val Val Val Trp
            340                 345                 350         
Phe Gly Val Asn Phe Ser Tyr Tyr Gly Leu Ser Leu Asp Val Ser Gly
        355                 360                 365             
Leu Gly Leu Asn Val Tyr Gln Thr Gln Leu Leu Phe Gly Ala Val Glu
    370                 375                 380                 
Leu Pro Ser Lys Leu Leu Val Tyr Leu Ser Val Arg Tyr Ala Gly Arg
385                 390                 395                 400 
Arg Leu Thr Gln Ala Gly Thr Leu Leu Gly Ala Ala Leu Ala Phe Gly
                405                 410                 415     
Thr Arg Leu Leu Val Ser Ser Asp Met Lys Ser Trp Ser Thr Val Leu
            420                 425                 430         
Ala Val Met Gly Lys Ala Phe Ser Glu Ala Ala Phe Thr Thr Ala Tyr
        435                 440                 445             
Leu Phe Thr Ser Glu Leu Tyr Pro Thr Val Leu Arg Gln Thr Gly Met
    450                 455                 460                 
Gly Leu Thr Ala Leu Val Gly Arg Leu Gly Gly Ser Leu Ala Pro Leu
465                 470                 475                 480 
Ala Ala Leu Leu Asp Gly Val Trp Leu Ser Leu Pro Lys Leu Thr Tyr
                485                 490                 495     
Gly Gly Ile Ala Leu Leu Ala Ala Gly Thr Ala Leu Leu Leu Pro Glu
            500                 505                 510         
Thr Arg Gln Ala Gln Leu Pro Glu Thr Ile Gln Asp Val Glu Arg Lys
        515                 520                 525             
Arg Cys Val His Arg Thr Val Ser Val Tyr Val
    530                 535                 


<210> 1293
<211> 211
<212> PRT
<213> Homo sapiens

<400> 1293
Met Ala Glu Lys Leu Ile Thr Gln Thr Phe Ser His His Asn Gln Leu
 1               5                  10                  15      
Ala Gln Lys Thr Arg Arg Glu Lys Arg Ala Arg Gln Glu Ala Glu Arg
            20                  25                  30          
Arg Glu Lys Ala Glu Arg Ala Ala Arg Leu Ala Lys Glu Ala Lys Ser
        35                  40                  45              
Glu Thr Ser Gly Pro Gln Ile Lys Glu Leu Thr Asp Glu Glu Ala Glu
    50                  55                  60                  
Arg Leu Gln Leu Glu Ile Asp Gln Lys Lys Asp Ala Glu Asn His Glu
65                  70                  75                  80  
Ala Gln Leu Lys Asn Gly Ser Leu Asp Ser Pro Gly Lys Gln Asp Thr
                85                  90                  95      
Glu Glu Asp Glu Glu Glu Asp Glu Lys Asp Lys Gly Lys Leu Lys Pro
            100                 105                 110         
Asn Leu Gly Asn Gly Ala Asp Leu Pro Asn Tyr Arg Trp Thr Gln Thr
        115                 120                 125             
Leu Ser Glu Leu Asp Leu Ala Val Pro Phe Cys Val Asn Phe Arg Leu
    130                 135                 140                 
Lys Gly Lys Asp Met Val Val Asp Ile Gln Arg Arg His Leu Arg Val
145                 150                 155                 160 
Gly Leu Lys Gly Gln Pro Ala Ile Ile Asp Gly Glu Leu Tyr Asn Glu
                165                 170                 175     
Val Lys Val Glu Glu Ser Ser Trp Leu Ile Glu Asp Gly Lys Val Val
            180                 185                 190         
Thr Val His Leu Glu Lys Ile Asn Lys Met Glu Trp Trp Ser Arg Leu
        195                 200                 205             
Val Ser Lys
    210     


<210> 1294
<211> 227
<212> PRT
<213> Homo sapiens

<400> 1294
Met Gln Glu Pro Arg Arg Val Thr His Cys Leu Gly Lys Arg Gly Val
 1               5                  10                  15      
Lys Thr Pro Gln Leu Gln Pro Gly Ser Ala Phe Leu Pro Arg Val Arg
            20                  25                  30          
Arg Gln Ser Phe Thr Ala Arg Ser Asp Ser Tyr Thr Thr Val Arg Asp
        35                  40                  45              
Phe Leu Ala Val Pro Arg Thr Ile Ser Ser Ala Ser Ala Thr Leu Ile
    50                  55                  60                  
Met Ala Val Ala Val Ser His Phe Arg Pro Gly Pro Glu Val Trp Asp
65                  70                  75                  80  
Thr Ala Ser Met Ala Ala Ser Lys Val Lys Gln Asp Met Pro Pro Pro
                85                  90                  95      
Gly Gly Tyr Gly Pro Ile Asp Tyr Lys Arg Asn Leu Pro Arg Arg Gly
            100                 105                 110         
Leu Ser Gly Tyr Ser Met Leu Ala Ile Gly Ile Gly Thr Leu Ile Tyr
        115                 120                 125             
Gly His Trp Ser Ile Met Lys Trp Asn Arg Glu Arg Arg Arg Leu Gln
    130                 135                 140                 
Ile Glu Asp Phe Glu Ala Arg Ile Ala Leu Leu Pro Leu Leu Gln Ala
145                 150                 155                 160 
Glu Thr Asp Arg Arg Thr Leu Gln Met Leu Arg Glu Asn Leu Glu Glu
                165                 170                 175     
Glu Ala Ile Ile Met Lys Asp Val Pro Asp Trp Lys Val Gly Glu Ser
            180                 185                 190         
Val Phe His Thr Thr Arg Trp Val Pro Pro Leu Ile Gly Glu Leu Tyr
        195                 200                 205             
Gly Leu Arg Thr Thr Glu Glu Ala Leu His Ala Ser His Gly Phe Met
    210                 215                 220                 
Trp Tyr Thr
225         


<210> 1295
<211> 427
<212> PRT
<213> Homo sapiens

<400> 1295
Met Gly Lys Glu Lys Thr His Ile Asn Ile Val Val Ile Gly His Val
 1               5                  10                  15      
Asp Ser Gly Lys Ser Thr Thr Thr Gly His Leu Ile Tyr Lys Cys Gly
            20                  25                  30          
Gly Ile Asp Lys Arg Thr Ile Glu Lys Phe Glu Lys Glu Ala Ala Glu
        35                  40                  45              
Met Gly Lys Gly Ser Phe Lys Tyr Ala Trp Val Leu Asp Lys Leu Lys
    50                  55                  60                  
Ala Glu Arg Glu Arg Gly Ile Thr Ile Asp Ile Ser Leu Trp Lys Phe
65                  70                  75                  80  
Glu Thr Ser Lys Tyr Tyr Val Thr Ile Ile Asp Ala Pro Gly His Arg
                85                  90                  95      
Asp Phe Ile Lys Asn Met Ile Thr Gly Thr Ser Gln Ala Asp Cys Ala
            100                 105                 110         
Val Leu Ile Val Ala Ala Gly Val Gly Glu Phe Glu Ala Gly Ile Ser
        115                 120                 125             
Lys Asn Gly Gln Thr Arg Glu His Ala Leu Leu Ala Tyr Thr Leu Gly
    130                 135                 140                 
Val Lys Gln Leu Ile Val Gly Val Asn Lys Met Asp Ser Thr Glu Pro
145                 150                 155                 160 
Pro Tyr Ser Gln Lys Arg Tyr Glu Glu Ile Val Lys Glu Val Ser Thr
                165                 170                 175     
Tyr Ile Lys Lys Ile Gly Tyr Asn Pro Asp Thr Val Ala Phe Val Pro
            180                 185                 190         
Ile Ser Gly Trp Asn Gly Asp Asn Met Leu Glu Pro Ser Ala Asn Met
        195                 200                 205             
Pro Trp Phe Lys Gly Trp Lys Val Thr Arg Lys Asp Gly Asn Ala Ser
    210                 215                 220                 
Gly Thr Thr Leu Leu Glu Ala Leu Asp Cys Ile Leu Pro Pro Thr Arg
225                 230                 235                 240 
Pro Thr Asp Lys Pro Leu Arg Leu Pro Leu Gln Asp Val Tyr Lys Ile
                245                 250                 255     
Gly Gly Ile Gly Thr Val Pro Val Gly Pro Ser Gly Asp Trp Cys Ser
            260                 265                 270         
Gln Pro Gly Met Val Val Thr Phe Ala Pro Val Asn Val Thr Thr Glu
        275                 280                 285             
Val Lys Ser Val Glu Met His His Glu Ala Leu Ser Glu Ala Leu Pro
    290                 295                 300                 
Gly Asp Asn Val Gly Phe Asn Val Lys Asn Val Ser Val Lys Asp Val
305                 310                 315                 320 
Arg Arg Gly Asn Val Ala Gly Asp Ser Lys Asn Asp Pro Pro Met Glu
                325                 330                 335     
Ala Ala Gly Phe Thr Ala Gln Val Ile Ile Leu Asn His Pro Gly Gln
            340                 345                 350         
Ile Ser Ala Gly Tyr Ala Pro Val Leu Asp Cys His Thr Ala His Ile
        355                 360                 365             
Ala Cys Lys Phe Ala Glu Leu Lys Glu Lys Ile Asp Arg Arg Ser Gly
    370                 375                 380                 
Lys Lys Leu Glu Asp Gly Pro Lys Phe Leu Lys Ser Gly Asp Ala Ala
385                 390                 395                 400 
Ile Val Asp Met Val Pro Gly Lys Pro Met Cys Val Glu Ser Phe Ser
                405                 410                 415     
Asp Tyr Pro Pro Leu Gly Ser Leu Cys Cys Ser
            420                 425         


<210> 1296
<211> 119
<212> PRT
<213> Homo sapiens

<400> 1296
Met Glu Ser Phe Ser Ser Lys Ser Leu Ala Leu Gln Ala Glu Lys Lys
 1               5                  10                  15      
Leu Leu Ser Lys Met Ala Gly Arg Ser Val Ala His Leu Phe Ile Asp
            20                  25                  30          
Glu Thr Ser Ser Glu Val Leu Asp Glu Leu Tyr Arg Val Ser Lys Glu
        35                  40                  45              
Tyr Thr His Ser Arg Pro Gln Ala Gln Arg Val Ile Lys Asp Leu Ile
    50                  55                  60                  
Lys Val Ala Ile Lys Val Ala Val Leu His Arg Asn Gly Ser Phe Gly
65                  70                  75                  80  
Pro Ser Glu Leu Ala Leu Ala Thr Arg Phe Arg Gln Lys Leu Arg Gln
                85                  90                  95      
Gly Ala Met Thr Ala Leu Ser Phe Gly Glu Val Asp Phe Thr Phe Glu
            100                 105                 110         
Ala Ala Val Leu Leu Ala Cys
        115                 


<210> 1297
<211> 736
<212> PRT
<213> Homo sapiens

<400> 1297
Met Ser Leu Leu Phe Ser Arg Cys Asn Ser Ile Val Thr Val Lys Lys
 1               5                  10                  15      
Asn Lys Arg His Met Ala Glu Val Asn Ala Ser Pro Leu Lys His Phe
            20                  25                  30          
Val Thr Ala Lys Lys Lys Ile Asn Gly Ile Phe Glu Gln Leu Gly Ala
        35                  40                  45              
Tyr Ile Gln Glu Ser Ala Thr Phe Leu Glu Asp Thr Tyr Arg Asn Ala
    50                  55                  60                  
Glu Leu Asp Pro Val Thr Thr Glu Glu Gln Val Leu Asp Val Lys Gly
65                  70                  75                  80  
Tyr Leu Ser Lys Val Arg Gly Ile Ser Glu Val Leu Ala Arg Arg His
                85                  90                  95      
Met Lys Val Ala Phe Phe Gly Arg Thr Ser Asn Gly Lys Ser Thr Val
            100                 105                 110         
Ile Asn Ala Met Leu Trp Asp Lys Val Leu Pro Ser Gly Ile Gly His
        115                 120                 125             
Thr Thr Asn Cys Phe Leu Arg Val Glu Gly Thr Asp Gly His Glu Ala
    130                 135                 140                 
Phe Leu Leu Thr Glu Gly Ser Glu Glu Lys Arg Ser Ala Lys Thr Val
145                 150                 155                 160 
Asn Gln Leu Ala His Ala Leu His Gln Asp Lys Gln Leu His Ala Gly
                165                 170                 175     
Ser Leu Val Ser Val Met Trp Pro Asn Ser Lys Cys Pro Leu Leu Lys
            180                 185                 190         
Asp Asp Leu Val Leu Met Asp Ser Pro Gly Ile Asp Val Thr Thr Glu
        195                 200                 205             
Leu Asp Ser Trp Ile Asp Lys Phe Cys Leu Asp Ala Asp Val Phe Val
    210                 215                 220                 
Leu Val Ala Asn Ser Glu Ser Thr Leu Met Gln Thr Glu Lys His Phe
225                 230                 235                 240 
Phe His Lys Val Arg Arg Gln His Met Glu Arg Cys Thr Ser Phe Leu
                245                 250                 255     
Val Asp Glu Leu Gly Val Val Asp Arg Ser Gln Ala Gly Asp Arg Ile
            260                 265                 270         
Phe Phe Val Ser Ala Lys Glu Val Leu Asn Ala Arg Ile Gln Lys Ala
        275                 280                 285             
Gln Gly Met Pro Glu Gly Gly Gly Ala Leu Ala Glu Gly Phe Gln Val
    290                 295                 300                 
Arg Met Phe Glu Phe Gln Asn Phe Glu Arg Arg Phe Glu Glu Cys Ile
305                 310                 315                 320 
Ser Gln Ser Ala Val Lys Thr Lys Phe Glu Gln His Thr Val Arg Ala
                325                 330                 335     
Lys Gln Ile Ala Glu Ala Val Arg Leu Ile Met Asp Ser Leu His Met
            340                 345                 350         
Ala Ala Arg Glu Gln Gln Val Tyr Cys Glu Glu Met Arg Glu Glu Arg
        355                 360                 365             
Gln Asp Arg Leu Lys Phe Ile Asp Lys Gln Leu Glu Leu Leu Ala Gln
    370                 375                 380                 
Asp Tyr Lys Leu Arg Ile Lys Gln Ile Thr Glu Glu Val Glu Arg Gln
385                 390                 395                 400 
Val Ser Thr Ala Met Ala Glu Glu Ile Arg Arg Leu Ser Val Leu Val
                405                 410                 415     
Asp Asp Tyr Gln Met Asp Phe His Pro Ser Pro Val Val Leu Lys Val
            420                 425                 430         
Tyr Lys Asn Glu Leu His Arg His Ile Glu Glu Gly Leu Gly Arg Asn
        435                 440                 445             
Met Ser Asp Arg Cys Ser Thr Ala Ile Thr Asn Ser Leu Gln Thr Met
    450                 455                 460                 
Gln Gln Asp Met Ile Asp Gly Leu Lys Pro Leu Leu Pro Val Ser Val
465                 470                 475                 480 
Arg Ser Gln Ile Asp Met Leu Val Pro Arg Gln Cys Phe Ser Leu Asn
                485                 490                 495     
Tyr Asp Leu Asn Cys Asp Lys Leu Cys Ala Asp Phe Gln Glu Asp Ile
            500                 505                 510         
Glu Phe His Phe Ser Leu Gly Trp Thr Met Leu Val Asn Arg Phe Leu
        515                 520                 525             
Gly Pro Lys Asn Ser Arg Arg Ala Leu Met Gly Tyr Asn Asp Gln Ala
    530                 535                 540                 
Ser Lys Val Pro His Leu Lys Gly Ile Val Gly Gly Pro Ala Ser His
545                 550                 555                 560 
Pro Ser Asp Ala Ser Gln Pro Gln His Ala Pro Thr Ala Thr Gly Leu
                565                 570                 575     
Ala His Pro Gly Gly Val His Gly Phe His Gly Tyr Arg Pro Gly Leu
            580                 585                 590         
Leu Asp Ile Gln Asp Leu His Gly His Ser Cys Cys Trp Arg Ser Val
        595                 600                 605             
Gly Trp Arg Leu Ile Ala Leu Ser Phe Gly Leu Tyr Gly Leu Leu Tyr
    610                 615                 620                 
Val Tyr Glu Arg Leu Thr Trp Thr Thr Lys Ala Lys Glu Arg Ala Phe
625                 630                 635                 640 
Lys Arg Gln Phe Val Glu His Ala Ser Glu Lys Leu Gln Leu Val Ile
                645                 650                 655     
Ser Tyr Thr Gly Ser Asn Cys Ser His Gln Val Gln Gln Glu Leu Ser
            660                 665                 670         
Gly Thr Phe Ala His Leu Cys Gln Gln Val Asp Val Thr Arg Glu Asn
        675                 680                 685             
Leu Glu Gln Glu Ile Ala Ala Met Asn Lys Lys Ile Glu Val Leu Asp
    690                 695                 700                 
Ser Leu Gln Ser Lys Ala Lys Leu Leu Arg Asn Lys Ala Gly Trp Leu
705                 710                 715                 720 
Asp Ser Glu Leu Asn Met Phe Thr His Gln Tyr Leu Gln Pro Ser Arg
                725                 730                 735     


<210> 1298
<211> 521
<212> PRT
<213> Homo sapiens

<400> 1298
Met Ala Ala Met Ala Val Ala Leu Arg Gly Leu Gly Gly Arg Phe Arg
 1               5                  10                  15      
Trp Arg Thr Gln Ala Val Ala Gly Gly Val Arg Gly Ala Ala Arg Gly
            20                  25                  30          
Ala Ala Gly Gln Arg Asp Tyr Asp Leu Leu Val Val Gly Gly Gly Ser
        35                  40                  45              
Gly Gly Leu Ala Cys Ala Lys Glu Ala Ala Gln Leu Gly Arg Lys Val
    50                  55                  60                  
Ser Val Val Asp Tyr Val Glu Pro Ser Pro Gln Gly Thr Arg Trp Gly
65                  70                  75                  80  
Leu Gly Gly Thr Cys Val Asn Val Gly Cys Ile Pro Lys Lys Leu Met
                85                  90                  95      
His Gln Ala Ala Leu Leu Gly Gly Leu Ile Gln Asp Ala Pro Asn Tyr
            100                 105                 110         
Gly Trp Glu Val Ala Gln Pro Val Pro His Asp Trp Arg Lys Met Ala
        115                 120                 125             
Glu Ala Val Gln Asn His Val Lys Ser Leu Asn Trp Gly His Arg Val
    130                 135                 140                 
Gln Leu Gln Asp Arg Lys Val Lys Tyr Phe Asn Ile Lys Ala Ser Phe
145                 150                 155                 160 
Val Asp Glu His Thr Val Cys Gly Val Ala Lys Gly Gly Lys Glu Ile
                165                 170                 175     
Leu Leu Ser Ala Asp His Ile Ile Ile Ala Thr Gly Gly Arg Pro Arg
            180                 185                 190         
Tyr Pro Thr His Ile Glu Gly Ala Leu Glu Tyr Gly Ile Thr Ser Asp
        195                 200                 205             
Asp Ile Phe Trp Leu Lys Glu Ser Pro Gly Lys Thr Leu Val Val Gly
    210                 215                 220                 
Ala Ser Tyr Val Ala Leu Glu Cys Ala Gly Phe Leu Thr Gly Ile Gly
225                 230                 235                 240 
Leu Asp Thr Thr Ile Met Met Arg Ser Ile Pro Leu Arg Gly Phe Asp
                245                 250                 255     
Gln Gln Met Ser Ser Met Val Ile Glu His Met Ala Ser His Gly Thr
            260                 265                 270         
Arg Phe Leu Arg Gly Cys Ala Pro Ser Arg Val Lys Arg Leu Pro Asp
        275                 280                 285             
Gly Gln Leu Gln Val Thr Trp Glu Asp Ser Thr Thr Gly Lys Glu Asp
    290                 295                 300                 
Thr Gly Thr Phe Asp Thr Val Leu Trp Ala Ile Gly Arg Val Pro Asp
305                 310                 315                 320 
Thr Arg Ser Leu Asn Leu Glu Lys Ala Gly Val Asp Thr Ser Pro Asp
                325                 330                 335     
Thr Gln Lys Ile Leu Val Asp Ser Arg Glu Ala Thr Ser Val Pro His
            340                 345                 350         
Ile Tyr Ala Ile Gly Asp Val Val Glu Gly Arg Pro Glu Leu Thr Pro
        355                 360                 365             
Thr Ala Ile Met Ala Gly Arg Leu Leu Val Gln Arg Leu Phe Gly Gly
    370                 375                 380                 
Ser Ser Asp Leu Met Asp Tyr Asp Asn Val Pro Thr Thr Val Phe Thr
385                 390                 395                 400 
Pro Leu Glu Tyr Gly Cys Val Gly Leu Ser Glu Glu Glu Ala Val Ala
                405                 410                 415     
Arg His Gly Gln Glu His Val Glu Val Tyr His Ala His Tyr Lys Pro
            420                 425                 430         
Leu Glu Phe Thr Val Ala Gly Arg Asp Ala Ser Gln Cys Tyr Val Lys
        435                 440                 445             
Met Val Cys Leu Arg Glu Pro Pro Gln Leu Val Leu Gly Leu His Phe
    450                 455                 460                 
Leu Gly Pro Asn Ala Gly Glu Val Thr Gln Gly Phe Ala Leu Gly Ile
465                 470                 475                 480 
Lys Cys Gly Ala Ser Tyr Ala Gln Val Met Arg Thr Val Gly Ile His
                485                 490                 495     
Pro Thr Cys Ser Glu Glu Val Val Lys Leu Arg Ile Ser Lys Arg Ser
            500                 505                 510         
Gly Leu Asp Pro Thr Val Thr Gly Cys
        515                 520     


<210> 1299
<211> 394
<212> PRT
<213> Homo sapiens

<400> 1299
Met Ala Met Ala Tyr Leu Ala Trp Arg Leu Ala Arg Arg Ser Cys Pro
 1               5                  10                  15      
Ser Ser Leu Gln Val Thr Ser Phe Pro Val Val Gln Leu His Met Asn
            20                  25                  30          
Arg Thr Ala Met Arg Ala Ser Gln Lys Asp Phe Glu Asn Ser Met Asn
        35                  40                  45              
Gln Val Lys Leu Leu Lys Lys Asp Pro Gly Asn Glu Val Lys Leu Lys
    50                  55                  60                  
Leu Tyr Ala Leu Tyr Lys Gln Ala Thr Glu Gly Pro Cys Asn Met Pro
65                  70                  75                  80  
Lys Pro Gly Val Phe Asp Leu Ile Asn Lys Ala Lys Trp Asp Ala Trp
                85                  90                  95      
Asn Ala Leu Gly Ser Leu Pro Lys Glu Ala Ala Arg Gln Asn Tyr Val
            100                 105                 110         
Asp Leu Val Ser Ser Leu Cys Pro Ser Leu Glu Ser Ser Ser Gln Val
        115                 120                 125             
Glu Pro Gly Thr Asp Arg Lys Ser Thr Gly Phe Glu Thr Leu Val Val
    130                 135                 140                 
Thr Ser Glu Asp Gly Ile Thr Lys Ile Met Phe Asn Arg Pro Lys Lys
145                 150                 155                 160 
Lys Asn Ala Ile Asn Thr Glu Met Tyr His Glu Ile Met Arg Ala Leu
                165                 170                 175     
Lys Ala Ala Ser Lys Asp Asp Ser Ile Ile Thr Val Leu Thr Gly Asn
            180                 185                 190         
Gly Asp Tyr Tyr Ser Ser Gly Asn Asp Leu Thr Asn Phe Thr Asp Ile
        195                 200                 205             
Pro Pro Gly Gly Val Glu Glu Lys Ala Lys Asn Asn Ala Val Leu Leu
    210                 215                 220                 
Arg Glu Phe Val Gly Cys Phe Ile Asp Phe Pro Lys Pro Leu Ile Ala
225                 230                 235                 240 
Val Val Asn Gly Pro Ala Val Gly Ile Ser Val Thr Leu Leu Gly Leu
                245                 250                 255     
Phe Asp Ala Val Tyr Ala Ser Asp Arg Ala Thr Phe His Thr Pro Phe
            260                 265                 270         
Ser His Leu Gly Gln Ser Pro Glu Gly Cys Ser Ser Tyr Thr Phe Pro
        275                 280                 285             
Lys Ile Met Ser Pro Ala Lys Ala Thr Glu Met Leu Ile Phe Gly Lys
    290                 295                 300                 
Lys Leu Thr Ala Gly Glu Ala Cys Ala Gln Gly Leu Val Thr Glu Val
305                 310                 315                 320 
Phe Pro Asp Ser Thr Phe Gln Lys Glu Val Trp Thr Arg Leu Lys Ala
                325                 330                 335     
Phe Ala Lys Leu Pro Pro Asn Ala Leu Arg Ile Ser Lys Glu Val Ile
            340                 345                 350         
Arg Lys Arg Glu Arg Glu Lys Leu His Ala Val Asn Ala Glu Glu Cys
        355                 360                 365             
Asn Val Leu Gln Gly Arg Trp Leu Ser Asp Glu Cys Thr Asn Ala Val
    370                 375                 380                 
Val Asn Phe Leu Ser Arg Lys Ser Lys Leu
385                 390                 


<210> 1300
<211> 179
<212> PRT
<213> Homo sapiens

<400> 1300
Met Thr Leu Asp Asn Ile Ser Arg Ala Ala Val Asp Arg Ile Ile Arg
 1               5                  10                  15      
Val Asp His Ala Gly Glu Tyr Gly Ala Asn Arg Ile Tyr Ala Trp Gln
            20                  25                  30          
Met Ala Val Leu Gly Arg Thr Ser Val Gly Pro Val Ile Gln Lys Met
        35                  40                  45              
Trp Asp Gln Glu Lys Asp His Leu Lys Lys Phe Asn Glu Leu Met Val
    50                  55                  60                  
Met Phe Arg Val Arg Pro Thr Val Leu Met Pro Leu Trp Asn Val Leu
65                  70                  75                  80  
Gly Phe Ala Leu Gly Ala Gly Thr Ala Leu Leu Gly Lys Glu Gly Ala
                85                  90                  95      
Met Ala Cys Thr Val Ala Val Glu Glu Ser Ile Ala His His Tyr Asn
            100                 105                 110         
Asn Gln Ile Arg Thr Leu Met Glu Glu Asp Pro Glu Lys Tyr Glu Glu
        115                 120                 125             
Leu Leu Gln Leu Ile Lys Lys Phe Arg Asp Glu Glu Leu Glu His His
    130                 135                 140                 
Asp Ile Gly Leu Asp His Asp Ala Glu Leu Ala Pro Ala Tyr Ala Val
145                 150                 155                 160 
Leu Lys Ser Ile Ile Gln Ala Gly Cys Arg Val Ala Ile Tyr Leu Ser
                165                 170                 175     
Glu Arg Leu
            


<210> 1301
<211> 200
<212> PRT
<213> Homo sapiens

<400> 1301
Met Ala Lys Lys Thr Tyr Asp Leu Leu Phe Lys Leu Leu Leu Ile Gly
 1               5                  10                  15      
Asp Ser Gly Val Gly Lys Thr Cys Val Leu Phe Arg Phe Ser Asp Asp
            20                  25                  30          
Ala Phe Asn Thr Thr Phe Ile Ser Thr Ile Gly Ile Asp Phe Lys Ile
        35                  40                  45              
Lys Thr Val Glu Leu Gln Gly Lys Lys Ile Lys Leu Gln Ile Trp Asp
    50                  55                  60                  
Thr Ala Gly Gln Glu Arg Phe His Thr Ile Thr Thr Ser Tyr Tyr Arg
65                  70                  75                  80  
Gly Ala Met Gly Ile Met Leu Val Tyr Asp Ile Thr Asn Gly Lys Ser
                85                  90                  95      
Phe Glu Asn Ile Ser Lys Trp Leu Arg Asn Ile Asp Glu His Ala Asn
            100                 105                 110         
Glu Asp Val Glu Arg Met Leu Leu Gly Asn Lys Cys Asp Met Asp Asp
        115                 120                 125             
Lys Arg Val Val Pro Lys Gly Lys Gly Gly Gln Ile Ala Arg Glu His
    130                 135                 140                 
Gly Ile Arg Phe Phe Glu Thr Ser Ala Lys Ala Asn Ile Asn Ile Glu
145                 150                 155                 160 
Lys Ala Phe Leu Thr Leu Ala Glu Asp Ile Leu Arg Lys Thr Pro Val
                165                 170                 175     
Lys Glu Pro Asn Ser Glu Asn Val Asp Ile Ser Ser Gly Gly Gly Val
            180                 185                 190         
Thr Gly Trp Lys Ser Lys Cys Cys
        195                 200 


<210> 1302
<211> 541
<212> PRT
<213> Homo sapiens

<400> 1302
Met Leu Ser His Thr Val Arg Lys His Leu Arg Lys Thr Arg Leu Glu
 1               5                  10                  15      
Leu Leu His Lys Glu Tyr Glu Asp Glu Ile Asp Cys Leu Gln Lys Glu
            20                  25                  30          
Val Glu Glu Leu Lys Ser Lys Asn Leu Ser Leu Glu Ser Gln Ile Lys
        35                  40                  45              
Ala Ile Leu Asp Pro Leu Thr Leu Val Gln Gly Asn Gln Asn Glu Asp
    50                  55                  60                  
Lys His Leu Val Thr Asp Asn Pro Ser Ile Ile Asn Pro Glu Thr Val
65                  70                  75                  80  
Ala Glu Trp Lys Lys Lys Leu Arg Thr Ala Asn Glu Ile Tyr Glu Lys
                85                  90                  95      
Val Lys Asp Asp Val Asp Lys Leu Lys Glu Ala Asn Lys Lys Leu Lys
            100                 105                 110         
Leu Glu Asn Gly Gly Leu Val Arg Glu Asn Leu Arg Leu Lys Ala Glu
        115                 120                 125             
Val Asp Asn Arg Ser Pro Gln Lys Phe Gly Arg Phe Ala Val Ala Ala
    130                 135                 140                 
Leu Gln Ser Lys Val Glu Gln Tyr Glu Arg Glu Thr Asn Arg Leu Lys
145                 150                 155                 160 
Lys Ala Leu Glu Arg Ser Asp Lys Tyr Ile Glu Glu Leu Glu Ser Gln
                165                 170                 175     
Val Ala Gln Leu Lys Asn Ser Ser Glu Glu Lys Glu Ala Met Asn Ser
            180                 185                 190         
Ile Cys Gln Thr Ala Leu Ser Ala Asp Gly Lys Gly Ser Lys Gly Ser
        195                 200                 205             
Glu Glu Asp Val Val Ser Lys Asn Gln Gly Asp Ser Ala Arg Lys Gln
    210                 215                 220                 
Pro Gly Ser Ser Thr Ser Ser Ser Ser His Leu Ala Lys Pro Ser Ser
225                 230                 235                 240 
Ser Arg Leu Cys Asp Thr Ser Ser Ala Arg Gln Glu Ser Thr Ser Lys
                245                 250                 255     
Ala Asp Leu Asn Cys Ser Lys Asn Lys Asp Leu Tyr Gln Glu Gln Val
            260                 265                 270         
Glu Val Met Leu Asp Val Thr Asp Thr Ser Met Asp Thr Tyr Leu Glu
        275                 280                 285             
Arg Glu Trp Gly Asn Lys Pro Ser Asp Cys Val Pro Tyr Lys Asp Glu
    290                 295                 300                 
Glu Leu Tyr Asp Phe Pro Ala Pro Cys Thr Pro Leu Ser Leu Ser Cys
305                 310                 315                 320 
Leu Gln Leu Ser Thr Pro Glu Asn Arg Glu Ser Ser Val Val Gln Ala
                325                 330                 335     
Gly Gly Ser Lys Lys His Ser Asn His Leu Arg Lys Leu Val Phe Asp
            340                 345                 350         
Asp Phe Cys Asp Ser Ser Asn Val Ser Asn Lys Asp Ser Ser Glu Asp
        355                 360                 365             
Asp Ile Ser Arg Ser Glu Asn Glu Lys Lys Ser Glu Cys Phe Ser Ser
    370                 375                 380                 
Thr Lys Thr Gly Phe Trp Asp Cys Cys Ser Thr Ser Tyr Ala Gln Asn
385                 390                 395                 400 
Leu Asp Phe Glu Ser Ser Glu Gly Asn Thr Ile Ala Asn Ser Val Gly
                405                 410                 415     
Glu Ile Ser Ser Lys Leu Ser Glu Lys Ser Gly Leu Cys Leu Ser Lys
            420                 425                 430         
Arg Leu Asn Ser Ile Arg Ser Phe Glu Met Asn Arg Thr Arg Thr Ser
        435                 440                 445             
Ser Glu Ala Ser Met Asp Ala Ala Tyr Leu Asp Lys Ile Ser Glu Leu
    450                 455                 460                 
Asp Ser Met Met Ser Glu Ser Asp Asn Ser Lys Ser Pro Cys Asn Asn
465                 470                 475                 480 
Gly Phe Lys Ser Leu Asp Leu Asp Gly Leu Ser Lys Ser Ser Gln Gly
                485                 490                 495     
Ser Glu Phe Leu Glu Glu Pro Asp Lys Leu Glu Glu Lys Thr Glu Leu
            500                 505                 510         
Asn Leu Ser Lys Gly Ser Leu Thr Asn Asp Gln Leu Glu Asn Gly Ser
        515                 520                 525             
Glu Trp Lys Pro Thr Ser Phe Phe Ser Pro Leu Ser Ile
    530                 535                 540     


<210> 1303
<211> 344
<212> PRT
<213> Homo sapiens

<400> 1303
Met Asp Phe Leu Val Leu Phe Leu Phe Tyr Leu Ala Ser Val Leu Met
 1               5                  10                  15      
Gly Leu Val Leu Ile Cys Val Cys Ser Lys Thr His Ser Leu Lys Gly
            20                  25                  30          
Leu Ala Arg Gly Gly Ala Gln Ile Phe Ser Cys Ile Ile Pro Glu Cys
        35                  40                  45              
Leu Gln Arg Ala Val His Gly Leu Leu His Tyr Leu Phe His Thr Arg
    50                  55                  60                  
Asn His Thr Phe Ile Val Leu His Leu Val Leu Gln Gly Met Val Tyr
65                  70                  75                  80  
Thr Glu Tyr Thr Trp Glu Val Phe Gly Tyr Cys Gln Glu Leu Glu Leu
                85                  90                  95      
Ser Leu His Tyr Leu Leu Leu Pro Tyr Leu Leu Leu Gly Val Asn Leu
            100                 105                 110         
Phe Phe Phe Thr Leu Thr Cys Gly Thr Asn Pro Gly Ile Ile Thr Lys
        115                 120                 125             
Ala Asn Glu Leu Leu Phe Leu His Val Tyr Glu Phe Asp Glu Val Met
    130                 135                 140                 
Phe Pro Lys Asn Val Arg Cys Ser Thr Cys Asp Leu Arg Lys Pro Ala
145                 150                 155                 160 
Arg Ser Lys His Cys Ser Val Cys Asn Trp Cys Val His Arg Phe Asp
                165                 170                 175     
His His Cys Val Trp Val Asn Asn Cys Ile Gly Ala Trp Asn Ile Arg
            180                 185                 190         
Tyr Phe Leu Ile Tyr Val Leu Thr Leu Thr Ala Ser Ala Ala Thr Val
        195                 200                 205             
Ala Ile Val Ser Thr Thr Phe Leu Val His Leu Val Val Met Ser Asp
    210                 215                 220                 
Leu Tyr Gln Glu Thr Tyr Ile Asp Asp Leu Gly His Leu His Val Met
225                 230                 235                 240 
Asp Thr Val Ile Leu Ile Gln Tyr Leu Phe Leu Thr Phe Pro Arg Ile
                245                 250                 255     
Val Phe Met Leu Gly Phe Val Val Val Leu Ser Phe Leu Leu Gly Gly
            260                 265                 270         
Tyr Leu Leu Ser Val Leu Tyr Leu Ala Ala Thr Asn Gln Thr Thr Asn
        275                 280                 285             
Glu Trp Tyr Arg Gly Val Trp Ala Trp Cys Gln Arg Cys Pro Leu Val
    290                 295                 300                 
Ala Trp Pro Pro Ser Ala Glu Pro Gln Val His Arg Asn Ile His Ser
305                 310                 315                 320 
His Gly Leu Arg Ser Asn Leu Gln Glu Ile Phe Leu Pro Ala Phe Pro
                325                 330                 335     
Cys His Glu Arg Lys Lys Gln Glu
            340                 


<210> 1304
<211> 286
<212> PRT
<213> Homo sapiens

<400> 1304
Met Ala Met Glu Gly Tyr Arg Arg Phe Leu Ala Leu Leu Gly Ser Ala
 1               5                  10                  15      
Leu Leu Val Gly Phe Leu Ser Val Ile Phe Ala Leu Val Trp Val Leu
            20                  25                  30          
His Tyr Arg Glu Gly Leu Gly Trp Asp Gly Ser Ala Leu Glu Phe Asn
        35                  40                  45              
Trp His Pro Val Leu Met Val Thr Gly Phe Val Phe Ile Gln Gly Ile
    50                  55                  60                  
Ala Ile Ile Val Tyr Arg Leu Pro Trp Thr Trp Lys Cys Ser Lys Leu
65                  70                  75                  80  
Leu Met Lys Ser Ile His Ala Gly Leu Asn Ala Val Ala Ala Ile Leu
                85                  90                  95      
Ala Ile Ile Ser Val Val Ala Val Phe Glu Asn His Asn Val Asn Asn
            100                 105                 110         
Ile Ala Asn Met Tyr Ser Leu His Ser Trp Val Gly Leu Ile Ala Val
        115                 120                 125             
Ile Cys Tyr Leu Leu Gln Leu Leu Ser Gly Phe Ser Val Phe Leu Leu
    130                 135                 140                 
Pro Trp Ala Pro Leu Ser Leu Arg Ala Phe Leu Met Pro Ile His Val
145                 150                 155                 160 
Tyr Ser Gly Ile Val Ile Phe Gly Thr Val Ile Ala Thr Ala Leu Met
                165                 170                 175     
Gly Leu Thr Glu Lys Leu Ile Phe Ser Leu Arg Asp Pro Ala Tyr Ser
            180                 185                 190         
Thr Phe Pro Pro Glu Gly Val Phe Val Asn Thr Leu Gly Leu Leu Ile
        195                 200                 205             
Leu Val Phe Gly Ala Leu Ile Phe Trp Ile Val Thr Arg Pro Gln Trp
    210                 215                 220                 
Lys Arg Pro Lys Glu Pro Asn Ser Thr Ile Leu His Pro Asn Gly Gly
225                 230                 235                 240 
Thr Glu Gln Gly Ala Arg Gly Ser Met Pro Ala Tyr Ser Gly Asn Asn
                245                 250                 255     
Met Asp Lys Ser Asp Ser Glu Leu Asn Asn Glu Val Ala Ala Arg Lys
            260                 265                 270         
Arg Asn Leu Ala Leu Asp Glu Ala Gly Gln Arg Ser Thr Met
        275                 280                 285     


<210> 1305
<211> 369
<212> PRT
<213> Homo sapiens

<400> 1305
Met Trp Ser Gly Arg Lys Leu Gly Ser Ser Gly Gly Trp Phe Leu Arg
 1               5                  10                  15      
Val Leu Gly Pro Val Gly Cys Asn Thr Lys Ala Ala Arg Pro Leu Ile
            20                  25                  30          
Ser Ser Ala Val Tyr Val Lys Asn Gln Leu Ser Gly Thr Leu Gln Ile
        35                  40                  45              
Lys Pro Gly Val Phe Asn Glu Tyr Arg Thr Ile Trp Phe Lys Ser Tyr
    50                  55                  60                  
Arg Thr Ile Phe Ser Cys Leu Asn Arg Ile Lys Ser Phe Arg Tyr Pro
65                  70                  75                  80  
Trp Ala Arg Leu Tyr Ser Thr Ser Gln Thr Thr Val Asp Ser Gly Glu
                85                  90                  95      
Val Lys Thr Phe Leu Ala Leu Ala His Lys Trp Trp Asp Glu Gln Gly
            100                 105                 110         
Val Tyr Ala Pro Leu His Ser Met Asn Asp Leu Arg Val Pro Phe Ile
        115                 120                 125             
Arg Asp Asn Leu Leu Lys Thr Ile Pro Asn His Gln Pro Gly Lys Pro
    130                 135                 140                 
Leu Leu Gly Met Lys Ile Leu Asp Val Gly Cys Gly Gly Gly Leu Leu
145                 150                 155                 160 
Thr Glu Pro Leu Gly Arg Leu Gly Ala Ser Val Ile Gly Ile Asp Pro
                165                 170                 175     
Val Asp Glu Asp Ile Lys Thr Ala Gln Cys His Lys Ser Phe Asp Pro
            180                 185                 190         
Val Leu Asp Lys Arg Ile Glu Tyr Arg Val Cys Ser Leu Glu Glu Ile
        195                 200                 205             
Val Glu Glu Thr Ala Glu Thr Phe Asp Ala Val Val Ala Ser Glu Val
    210                 215                 220                 
Val Glu His Val Ile Asp Leu Glu Thr Phe Leu Gln Cys Cys Cys Gln
225                 230                 235                 240 
Val Leu Lys Pro Gly Gly Ser Leu Phe Ile Thr Thr Ile Asn Lys Thr
                245                 250                 255     
Gln Leu Ser Tyr Ala Leu Gly Ile Val Phe Ser Glu Gln Ile Ala Ser
            260                 265                 270         
Ile Val Pro Lys Gly Thr His Thr Trp Glu Lys Phe Val Ser Pro Glu
        275                 280                 285             
Thr Leu Glu Ser Ile Leu Glu Ser Asn Gly Leu Ser Val Gln Thr Val
    290                 295                 300                 
Val Gly Met Leu Tyr Asn Pro Phe Ser Gly Tyr Trp His Trp Ser Glu
305                 310                 315                 320 
Asn Thr Ser Leu Asn Tyr Ala Ala His Ala Val Lys Ser Arg Val Gln
                325                 330                 335     
Glu His Pro Ala Ser Ala Glu Phe Val Leu Lys Gly Glu Thr Glu Glu
            340                 345                 350         
Leu Gln Ala Asn Ala Cys Thr Asn Pro Ala Val His Glu Lys Leu Lys
        355                 360                 365             
Lys
    


<210> 1306
<211> 494
<212> PRT
<213> Homo sapiens

<400> 1306
Met Met Thr Thr Leu Gln Asn Lys Glu Glu Cys Gly Lys Gly Pro Lys
 1               5                  10                  15      
Arg Ile Phe Ala Pro Pro Ala Gln Lys Ser Tyr Ser Leu Leu Pro Cys
            20                  25                  30          
Ser Pro Asn Ser Pro Lys Glu Glu Thr Pro Gly Ile Ser Ser Pro Glu
        35                  40                  45              
Thr Glu Ala Arg Ile Ser Leu Pro Lys Ala Ser Leu Lys Lys Lys Glu
    50                  55                  60                  
Glu Lys Ala Thr Met Lys Asn Val Pro Ser Arg Glu Gln Glu Lys Lys
65                  70                  75                  80  
Arg Lys Ala Gln Ile Asn Lys Gln Ala Glu Lys Lys Glu Lys Glu Lys
                85                  90                  95      
Ser Ser Leu Thr Asn Ala Glu Phe Glu Glu Ile Val Gln Ile Val Leu
            100                 105                 110         
Gln Lys Ser Leu Gln Glu Cys Leu Gly Met Gly Ser Gly Leu Asp Phe
        115                 120                 125             
Ala Glu Thr Ser Cys Ala Gln Pro Val Val Ser Thr Gln Ser Asp Lys
    130                 135                 140                 
Glu Pro Gly Ile Thr Ala Ser Ala Thr Asp Thr Asp Asn Ala Asn Gly
145                 150                 155                 160 
Glu Glu Val Pro His Thr Gln Glu Ile Ser Val Ser Trp Glu Gly Glu
                165                 170                 175     
Ala Ala Pro Glu Ile Arg Thr Ser Lys Leu Gly Gln Pro Asp Pro Ala
            180                 185                 190         
Pro Ser Lys Lys Lys Ser Asn Arg Leu Thr Leu Ser Lys Arg Lys Lys
        195                 200                 205             
Glu Ala His Glu Lys Val Glu Lys Thr Gln Gly Gly His Glu His Arg
    210                 215                 220                 
Gln Glu Asp Arg Leu Lys Lys Thr Val Gln Asp His Ser Gln Ile Arg
225                 230                 235                 240 
Asp Gln Gln Lys Gly Glu Ile Ser Gly Phe Gly Gln Cys Leu Val Trp
                245                 250                 255     
Val Gln Cys Ser Phe Pro Asn Cys Gly Lys Trp Arg Arg Leu Cys Gly
            260                 265                 270         
Asn Ile Asp Pro Ser Val Leu Pro Asp Asn Trp Ser Cys Asp Gln Asn
        275                 280                 285             
Thr Asp Val Gln Tyr Asn Arg Cys Asp Ile Pro Glu Glu Thr Trp Thr
    290                 295                 300                 
Gly Leu Glu Ser Asp Val Ala Tyr Ala Ser Tyr Ile Pro Gly Ser Ile
305                 310                 315                 320 
Ile Trp Ala Lys Gln Tyr Gly Tyr Pro Trp Trp Pro Gly Met Ile Glu
                325                 330                 335     
Ser Asp Pro Asp Leu Gly Glu Tyr Phe Leu Phe Thr Ser His Leu Asp
            340                 345                 350         
Ser Leu Pro Ser Lys Tyr His Val Thr Phe Phe Gly Glu Thr Val Ser
        355                 360                 365             
Arg Ala Trp Ile Pro Val Asn Met Leu Lys Asn Phe Gln Glu Leu Ser
    370                 375                 380                 
Leu Glu Leu Ser Val Met Lys Lys Arg Arg Asn Asp Cys Ser Gln Lys
385                 390                 395                 400 
Leu Gly Val Ala Leu Met Met Ala Gln Glu Ala Glu Gln Ile Ser Ile
                405                 410                 415     
Gln Glu Arg Val Asn Leu Phe Gly Phe Trp Ser Arg Phe Asn Gly Ser
            420                 425                 430         
Asn Ser Asn Gly Glu Arg Lys Asp Leu Gln Leu Ser Gly Leu Asn Ser
        435                 440                 445             
Pro Gly Ser Cys Leu Glu Lys Lys Glu Lys Glu Glu Glu Leu Glu Lys
    450                 455                 460                 
Glu Glu Gly Glu Lys Thr Asp Pro Ile Leu Pro Ile Arg Lys Arg Val
465                 470                 475                 480 
Lys Ile Gln Thr Gln Lys Asn Gln Ala Lys Arg Ala Trp Gly
                485                 490                 


<210> 1307
<211> 110
<212> PRT
<213> Homo sapiens

<400> 1307
Met Gly Gly Gln Ala Gly Leu Arg Thr Gly Arg Thr Lys Arg Gly Glu
 1               5                  10                  15      
Glu Arg Pro Cys Gln Gly Leu Gln Ala Gly Ser Pro Gln Leu Leu Pro
            20                  25                  30          
Gly Thr Ser Pro Thr Gly Asp Cys Arg Ala Leu Gly Trp Val Thr Pro
        35                  40                  45              
Pro Ala Pro Arg Lys Thr Ser Ser Leu Ala Thr Pro Arg Pro Leu Ser
    50                  55                  60                  
Ser Lys Gln Ser Ala Arg Ser Ser Ser Gly Ser Pro Arg Asn Arg Ala
65                  70                  75                  80  
Pro Cys Arg Thr Ser Thr Ala Asp Arg Pro Arg Leu Ala Asp Leu Pro
                85                  90                  95      
Ser Ile Arg Phe Leu Cys Lys Gln Asp Gln Lys Glu Ile Asn
            100                 105                 110 


<210> 1308
<211> 1196
<212> PRT
<213> Homo sapiens

<400> 1308
Met Pro Thr Ala Glu Ser Glu Ala Lys Val Lys Thr Lys Val Arg Phe
 1               5                  10                  15      
Glu Lys Leu Leu Lys Thr His Ser Asp Leu Met Arg Glu Lys Lys Lys
            20                  25                  30          
Leu Lys Lys Lys Leu Val Arg Ser Glu Glu Asn Ile Ser Pro Asp Thr
        35                  40                  45              
Ile Arg Ser Asn Leu His Tyr Met Lys Glu Thr Thr Ser Asp Asp Pro
    50                  55                  60                  
Asp Thr Ile Arg Ser Asn Leu Pro His Ile Lys Glu Thr Thr Ser Asp
65                  70                  75                  80  
Asp Val Ser Ala Ala Asn Thr Asn Asn Leu Lys Lys Ser Thr Arg Val
                85                  90                  95      
Thr Lys Asn Lys Leu Arg Asn Thr Gln Leu Ala Thr Glu Asn Pro Asn
            100                 105                 110         
Gly Asp Ala Ser Val Glu Glu Asp Lys Gln Gly Lys Pro Asn Lys Lys
        115                 120                 125             
Val Ile Lys Thr Val Pro Gln Leu Thr Thr Gln Asp Leu Lys Pro Glu
    130                 135                 140                 
Thr Pro Glu Asn Lys Val Asp Ser Thr His Gln Lys Thr His Thr Lys
145                 150                 155                 160 
Pro Gln Pro Gly Val Asp His Gln Lys Ser Glu Lys Ala Asn Glu Gly
                165                 170                 175     
Arg Glu Glu Thr Asp Leu Glu Glu Asp Glu Glu Leu Met Gln Ala Tyr
            180                 185                 190         
Gln Cys His Val Thr Glu Glu Met Ala Lys Glu Ile Lys Arg Lys Ile
        195                 200                 205             
Arg Lys Lys Leu Lys Glu Gln Leu Thr Tyr Phe Pro Ser Asp Thr Leu
    210                 215                 220                 
Phe His Asp Asp Lys Leu Ser Ser Glu Lys Arg Lys Lys Lys Lys Glu
225                 230                 235                 240 
Val Pro Val Phe Ser Lys Ala Glu Thr Ser Thr Leu Thr Ile Ser Gly
                245                 250                 255     
Asp Thr Val Glu Gly Glu Gln Lys Lys Glu Ser Ser Val Arg Ser Val
            260                 265                 270         
Ser Ser Asp Ser His Gln Asp Asp Glu Ile Ser Ser Met Glu Gln Ser
        275                 280                 285             
Thr Glu Asp Ser Met Gln Asp Asp Thr Lys Pro Lys Pro Lys Lys Thr
    290                 295                 300                 
Lys Lys Lys Thr Lys Ala Val Ala Asp Asn Asn Glu Asp Val Asp Gly
305                 310                 315                 320 
Asp Gly Val His Glu Ile Thr Ser Arg Asp Ser Pro Val Tyr Pro Lys
                325                 330                 335     
Cys Leu Leu Asp Asp Asp Leu Val Leu Gly Val Tyr Ile His Arg Thr
            340                 345                 350         
Asp Arg Leu Lys Ser Asp Phe Met Ile Ser His Pro Met Val Lys Ile
        355                 360                 365             
His Val Val Asp Glu His Thr Gly Gln Tyr Val Lys Lys Asp Asp Ser
    370                 375                 380                 
Gly Arg Pro Val Ser Ser Tyr Tyr Glu Lys Glu Asn Val Asp Tyr Ile
385                 390                 395                 400 
Leu Pro Ile Met Thr Gln Pro Tyr Asp Phe Lys Gln Leu Lys Ser Arg
                405                 410                 415     
Leu Pro Glu Trp Glu Glu Gln Ile Val Phe Asn Glu Asn Phe Pro Tyr
            420                 425                 430         
Leu Leu Arg Gly Ser Asp Glu Ser Pro Lys Val Ile Leu Phe Phe Glu
        435                 440                 445             
Ile Leu Asp Phe Leu Ser Val Asp Glu Ile Lys Asn Asn Ser Glu Val
    450                 455                 460                 
Gln Asn Gln Glu Cys Gly Phe Arg Lys Ile Ala Trp Ala Phe Leu Lys
465                 470                 475                 480 
Leu Leu Gly Ala Asn Gly Asn Ala Asn Ile Asn Ser Lys Leu Arg Leu
                485                 490                 495     
Gln Leu Tyr Tyr Pro Pro Thr Lys Pro Arg Ser Pro Leu Ser Val Val
            500                 505                 510         
Glu Ala Phe Glu Trp Trp Ser Lys Cys Pro Arg Asn His Tyr Pro Ser
        515                 520                 525             
Thr Leu Tyr Val Thr Val Arg Gly Leu Lys Val Pro Asp Cys Ile Lys
    530                 535                 540                 
Pro Ser Tyr Arg Ser Met Met Ala Leu Gln Glu Glu Lys Gly Lys Pro
545                 550                 555                 560 
Val His Cys Glu Arg His His Glu Ser Ser Ser Val Asp Thr Glu Pro
                565                 570                 575     
Gly Leu Glu Glu Ser Lys Glu Val Ile Lys Trp Lys Arg Leu Pro Gly
            580                 585                 590         
Gln Ala Cys Arg Ile Pro Asn Lys His Leu Phe Ser Leu Asn Ala Gly
        595                 600                 605             
Glu Arg Gly Cys Phe Cys Leu Asp Phe Ser His Asn Gly Arg Ile Leu
    610                 615                 620                 
Ala Ala Ala Cys Ala Ser Arg Asp Gly Tyr Pro Ile Ile Leu Tyr Glu
625                 630                 635                 640 
Ile Pro Ser Gly Arg Phe Met Arg Glu Leu Cys Gly His Leu Asn Ile
                645                 650                 655     
Ile Tyr Asp Leu Ser Trp Ser Lys Asp Asp His Tyr Ile Leu Thr Ser
            660                 665                 670         
Ser Ser Asp Gly Thr Ala Arg Ile Trp Lys Asn Glu Ile Asn Asn Thr
        675                 680                 685             
Asn Thr Phe Arg Val Leu Pro His Pro Ser Phe Val Tyr Thr Ala Lys
    690                 695                 700                 
Phe His Pro Ala Val Arg Glu Leu Val Val Thr Gly Cys Tyr Asp Ser
705                 710                 715                 720 
Met Ile Arg Ile Trp Lys Val Glu Met Arg Glu Asp Ser Ala Ile Leu
                725                 730                 735     
Val Arg Gln Phe Asp Val His Lys Ser Phe Ile Asn Ser Leu Cys Phe
            740                 745                 750         
Asp Thr Glu Gly His His Met Tyr Ser Gly Asp Cys Thr Gly Val Ile
        755                 760                 765             
Val Val Trp Asn Thr Tyr Val Lys Ile Asn Asp Leu Glu His Ser Val
    770                 775                 780                 
His His Trp Thr Ile Asn Lys Glu Ile Lys Glu Thr Glu Phe Lys Gly
785                 790                 795                 800 
Ile Pro Ile Ser Tyr Leu Glu Ile His Pro Asn Gly Lys Arg Leu Leu
                805                 810                 815     
Ile His Thr Lys Asp Ser Thr Leu Arg Ile Met Asp Leu Arg Ile Leu
            820                 825                 830         
Val Ala Arg Lys Phe Val Gly Ala Ala Asn Tyr Arg Glu Lys Ile His
        835                 840                 845             
Ser Thr Leu Thr Pro Cys Gly Thr Phe Leu Phe Ala Gly Ser Glu Asp
    850                 855                 860                 
Gly Ile Val Tyr Val Trp Asn Pro Glu Thr Gly Glu Gln Val Ala Met
865                 870                 875                 880 
Tyr Ser Asp Leu Pro Phe Lys Ser Pro Ile Arg Asp Ile Ser Tyr His
                885                 890                 895     
Pro Phe Glu Asn Met Val Ala Phe Cys Ala Phe Gly Gln Asn Glu Pro
            900                 905                 910         
Ile Leu Leu Tyr Ile Tyr Asp Phe His Val Ala Gln Gln Glu Ala Glu
        915                 920                 925             
Met Phe Lys Arg Tyr Asn Gly Thr Phe Pro Leu Pro Gly Ile His Gln
    930                 935                 940                 
Ser Gln Asp Ala Leu Cys Thr Cys Pro Lys Leu Pro His Gln Gly Ser
945                 950                 955                 960 
Phe Gln Ile Asp Glu Phe Val His Thr Glu Ser Ser Ser Thr Lys Met
                965                 970                 975     
Gln Leu Val Lys Gln Arg Leu Glu Thr Val Thr Glu Val Ile Arg Ser
            980                 985                 990         
Cys Ala Ala Lys Val Asn Lys Asn Leu Ser Phe Thr Ser Pro Pro Ala
        995                 1000                1005            
Val Ser Ser Gln Gln Ser Lys Leu Lys Gln Ser Asn Met Leu Thr Ala
    1010                1015                1020                
Gln Glu Ile Leu His Gln Phe Gly Phe Thr Gln Thr Gly Ile Ile Ser
1025                1030                1035                1040
Ile Glu Arg Lys Pro Cys Asn His Gln Val Asp Thr Ala Pro Thr Val
                1045                1050                1055    
Val Ala Leu Tyr Asp Tyr Thr Ala Asn Arg Ser Asp Glu Leu Thr Ile
            1060                1065                1070        
His Arg Gly Asp Ile Ile Arg Val Phe Phe Lys Asp Asn Glu Asp Trp
        1075                1080                1085            
Trp Tyr Gly Ser Ile Gly Lys Gly Gln Glu Gly Tyr Phe Pro Ala Asn
    1090                1095                1100                
His Val Ala Ser Glu Thr Leu Tyr Gln Glu Leu Pro Pro Glu Ile Lys
1105                1110                1115                1120
Glu Arg Ser Pro Pro Leu Ser Pro Glu Glu Lys Thr Lys Ile Glu Lys
                1125                1130                1135    
Ser Pro Ala Pro Gln Lys Gln Ser Ile Asn Lys Asn Lys Ser Gln Asp
            1140                1145                1150        
Phe Arg Leu Gly Ser Glu Ser Met Thr His Ser Glu Met Arg Lys Glu
        1155                1160                1165            
Gln Ser His Glu Asp Gln Gly His Ile Met Asp Thr Arg Met Arg Lys
    1170                1175                1180                
Asn Lys Gln Ala Gly Arg Lys Val Thr Leu Ile Glu
1185                1190                1195    


<210> 1309
<211> 1514
<212> PRT
<213> Homo sapiens

<400> 1309
Arg Thr Gly Arg Leu Val Ser Leu Ser Ala Cys Gly Arg Thr Ala Arg
 1               5                  10                  15      
Arg Gln Gln Pro Gly Gln Glu Phe Asn His Gly Leu Val Leu Ser Arg
            20                  25                  30          
Glu Pro Leu Arg Asp Gly Arg Val Phe Thr Val Arg Ile Asp Arg Lys
        35                  40                  45              
Val Asn Ser Trp Ser Gly Ser Ile Glu Ile Gly Val Thr Ala Leu Asp
    50                  55                  60                  
Pro Ser Val Leu Asp Phe Pro Ser Ser Ala Thr Gly Leu Lys Gly Gly
65                  70                  75                  80  
Ser Trp Val Val Ser Gly Cys Ser Val Leu Arg Asp Gly Arg Ser Val
                85                  90                  95      
Leu Glu Glu Tyr Gly Gln Asp Leu Asp Gln Leu Gly Glu Gly Asp Arg
            100                 105                 110         
Val Gly Val Glu Arg Thr Val Ala Gly Glu Leu Arg Leu Trp Val Asn
        115                 120                 125             
Gly Arg Asp Cys Gly Val Ala Ala Thr Gly Leu Pro Pro Arg Val Trp
    130                 135                 140                 
Ala Val Val Asp Leu Tyr Gly Lys Cys Thr Gln Ile Thr Val Leu Pro
145                 150                 155                 160 
Pro Glu Pro Gly Phe Ser Pro Pro Thr Pro Ile Pro Thr Pro Pro Leu
                165                 170                 175     
Glu Pro Leu Ala Pro Ser Glu Asp Ser Ala Leu Ala Glu Gln Gly Thr
            180                 185                 190         
Ser Ala Asp Glu Ala Phe Met Val Ser Pro Ala Gln Ala Arg Pro Glu
        195                 200                 205             
Thr Phe Pro Asn Ser Leu Glu Ser His Asn Asp Phe Ala Asn Met Glu
    210                 215                 220                 
Leu Ser Glu Val Val Ser Asn Thr Ile Leu Ser Ala Tyr Asn Gly Gly
225                 230                 235                 240 
Leu Leu Asn Val Asn Leu Ser Ser Pro Pro Ala Gly Glu Gly Leu Gly
                245                 250                 255     
Ser Ser Gly Ala Ala Thr Ser Pro Ile Leu Thr Ser Asn Asp Ala Leu
            260                 265                 270         
Leu Phe His Glu Lys Cys Gly Thr Leu Ile Lys Leu Ser Asn Asn Asn
        275                 280                 285             
Lys Thr Ala Glu Arg Arg Arg Pro Leu Asp Glu Phe Asn Asn Gly Val
    290                 295                 300                 
Val Met Thr Asn Arg Pro Leu Arg Gly Asn Glu Met Phe Glu Ile Arg
305                 310                 315                 320 
Ile Asp Lys Leu Val Asp Lys Trp Ser Gly Ser Ile Glu Ile Gly Val
                325                 330                 335     
Thr Thr His Asn Pro Asn Ser Leu Glu Tyr Pro Ala Thr Met Thr Asn
            340                 345                 350         
Leu Gln Ser Gly Thr Ile Met Met Ser Gly Cys Gly Ile Leu Thr Asn
        355                 360                 365             
Gly Lys Gly Thr Arg Arg Glu Tyr Cys Glu Phe Ser Leu Asp Glu Leu
    370                 375                 380                 
Gln Glu Gly Asp His Ile Gly Leu Thr Arg Lys Ser Asn Ser Ala Leu
385                 390                 395                 400 
His Phe Phe Ile Asn Gly Ile Asp Gln Gly Val Ala Thr Pro Leu Thr
                405                 410                 415     
Pro Pro Val Val Tyr Gly Val Val Asp Leu Tyr Gly Met Ala Val Lys
            420                 425                 430         
Val Thr Ile Val His Asn Asn Asn His Ser Asp Arg Leu Arg Arg Asn
        435                 440                 445             
Asn Ala Ile Leu Arg Ala Leu Ser Pro Glu Gly Ala Leu Arg Arg Ala
    450                 455                 460                 
Ala Pro Ala Ala Gln Ala Glu Pro Glu Arg Leu Leu Phe His Pro Asn
465                 470                 475                 480 
Cys Gly Gln Lys Ala Ala Ile Thr His Glu Gly Arg Thr Ala Leu Arg
                485                 490                 495     
Pro His Ala Thr Asp Asp Phe Asn His Gly Val Val Leu Ser Ser Arg
            500                 505                 510         
Ala Leu Arg Asp Gly Glu Val Phe Gln Val Arg Ile Asp Lys Met Val
        515                 520                 525             
Asp Lys Trp Ala Gly Ser Ile Glu Ile Gly Val Thr Thr His Asn Pro
    530                 535                 540                 
Ala Tyr Leu Gln Leu Pro Ser Thr Met Thr Asn Leu Arg Ser Gly Thr
545                 550                 555                 560 
Trp Met Met Thr Gly Asn Gly Val Met His Asn Gly Thr Thr Ile Leu
                565                 570                 575     
Asp Glu Tyr Gly His Asn Leu Asp Arg Leu Lys Ala Gly Asp Ala Val
            580                 585                 590         
Gly Val Val Arg Arg Glu Asp Gly Thr Leu His Phe Phe Val Asn Gly
        595                 600                 605             
Met Thr Gln Gly Pro Ala Ala Trp Asn Val Pro Pro Gly Val Tyr Ala
    610                 615                 620                 
Val Val Asp Leu Tyr Gly Gln Ala Ala Gln Ala Thr Ile Val Asp Asp
625                 630                 635                 640 
Val Glu Val Ala Pro Val Pro Glu Pro Leu Pro Glu Gly Asn Asn Gln
                645                 650                 655     
Val Ser Pro Ser Ser Pro Ser Ser Gly Ala Gly Gly Ser Asp Leu Arg
            660                 665                 670         
Phe His Gln Leu His Gly Ser Asn Ala Val Ile Thr Asn Gly Gly Arg
        675                 680                 685             
Thr Ala Leu Arg His Asn Cys Arg Ser Glu Phe Asn Asp Ala Ile Val
    690                 695                 700                 
Ile Ser Asn Arg Ala Leu Arg Asp Gly Glu Leu Phe Glu Ile Val Ile
705                 710                 715                 720 
Gln Lys Met Val Asp Arg Trp Ser Gly Ser Ile Glu Ala Gly Val Thr
                725                 730                 735     
Ala Ile Arg Pro Glu Asp Leu Glu Phe Pro Asn Thr Met Thr Asp Ile
            740                 745                 750         
Asp Tyr Asp Thr Trp Met Leu Ser Gly Thr Ala Ile Met Gln Asp Gly
        755                 760                 765             
Asn Thr Met Arg Asn Asn Tyr Gly Cys Asp Leu Asp Ala Leu Gly Thr
    770                 775                 780                 
Gly Ala Arg Ile Gly Met Met Arg Thr Ala Lys Gly Asp Leu His Tyr
785                 790                 795                 800 
Phe Ile Asn Gly Gln Asp Gln Gly Ala Ala Cys Ser Gly Leu Pro Pro
                805                 810                 815     
Glu Val Tyr Ala Val Val Asp Leu Tyr Gly Gln Cys Val Gln Val Ser
            820                 825                 830         
Ile Thr Asn Ala Thr Gly Pro Met Asp Asn Ser Leu Ala Thr Ser Asn
        835                 840                 845             
Thr Ala Thr Glu Lys Ser Phe Pro Leu His Ser Pro Val Ala Gly Val
    850                 855                 860                 
Ala His Arg Phe His Ser Thr Cys Gly Lys Asn Val Thr Leu Glu Glu
865                 870                 875                 880 
Asp Gly Thr Arg Ala Val Arg Ala Ala Gly Tyr Ala His Gly Leu Val
                885                 890                 895     
Phe Ser Thr Lys Glu Leu Arg Ala Glu Glu Val Phe Glu Val Lys Val
            900                 905                 910         
Glu Glu Leu Asp Glu Lys Trp Ala Gly Ser Leu Arg Leu Gly Leu Thr
        915                 920                 925             
Thr Leu Ala Pro Gly Glu Met Gly Pro Gly Ala Gly Gly Gly Gly Pro
    930                 935                 940                 
Gly Leu Pro Pro Ser Leu Pro Glu Leu Arg Thr Lys Thr Thr Trp Met
945                 950                 955                 960 
Val Ser Ser Cys Glu Val Arg Arg Asp Gly Gln Leu Gln Arg Met Asn
                965                 970                 975     
Tyr Gly Arg Asn Leu Glu Arg Leu Gly Val Gly Ser Arg Val Gly Val
            980                 985                 990         
Arg Arg Gly Ala Asp Asp Thr Met His Ile Leu Val Asp Gly Glu Asp
        995                 1000                1005            
Met Gly Pro Ala Ala Thr Gly Ile Ala Lys Asn Val Trp Ala Val Leu
    1010                1015                1020                
Asp Leu Tyr Gly Pro Val Arg Gly Val Ser Ile Val Ser Ser Thr Arg
1025                1030                1035                1040
Leu Glu Glu Ser Glu Gly Thr Gln Pro Pro Ser Pro Ser Ser Asp Thr
                1045                1050                1055    
Gly Ser Glu Gly Glu Glu Asp Asp Glu Gly Glu Glu His Gly Leu Gly
            1060                1065                1070        
Gly Gln Asn Glu Val Gly Ile Ile Pro Thr Thr Leu Glu Phe Leu Glu
        1075                1080                1085            
Asn His Gly Lys Asn Ile Leu Leu Ser Asn Gly Asn Arg Thr Ala Thr
    1090                1095                1100                
Arg Val Ala Ser Tyr Asn Gln Gly Ile Val Val Ile Asn Gln Pro Leu
1105                1110                1115                1120
Val Pro Gln Leu Leu Val Gln Val Arg Ile Asp Phe Leu Asn Arg Gln
                1125                1130                1135    
Trp Thr Ser Ser Leu Val Leu Gly Val Ile Thr Cys Ala Pro Glu Arg
            1140                1145                1150        
Leu Asn Phe Pro Ala Ser Ala Cys Ala Leu Lys Arg Ala Ala Trp Leu
        1155                1160                1165            
Leu Arg Gly Arg Gly Val Phe His Asn Gly Leu Lys Ile Cys Glu Lys
    1170                1175                1180                
Phe Gly Pro Asn Leu Asp Thr Cys Pro Glu Gly Thr Ile Leu Gly Leu
1185                1190                1195                1200
Arg Leu Asp Ser Ser Gly Gly Leu His Leu His Val Asn Gly Val Asp
                1205                1210                1215    
Gln Gly Val Ala Val Pro Asp Val Pro Gln Pro Cys His Ala Leu Val
            1220                1225                1230        
Asp Leu Tyr Gly Gln Cys Glu Gln Val Thr Ile Val Asn Pro Glu Pro
        1235                1240                1245            
Gly Ala Ala Ser Gly Lys Ser Ala Gly Thr Gln Gly Asp Met Glu Lys
    1250                1255                1260                
Ala Asp Met Val Asp Gly Ile Lys Glu Ser Val Cys Trp Gly Pro Pro
1265                1270                1275                1280
Pro Ala Ala Ser Pro Leu Lys Ser Cys Glu Tyr His Ala Leu Cys Ser
                1285                1290                1295    
Arg Phe Gln Glu Leu Leu Leu Leu Pro Glu Asp Tyr Phe Met Pro Pro
            1300                1305                1310        
Pro Lys Arg Ser Leu Cys Tyr Cys Glu Ser Cys Arg Lys Leu Arg Gly
        1315                1320                1325            
Asp Glu Ala His Arg Arg Arg Gly Glu Pro Pro Arg Glu Tyr Ala Leu
    1330                1335                1340                
Pro Phe Gly Trp Cys Arg Phe Asn Leu Arg Val Asn Pro Arg Leu Glu
1345                1350                1355                1360
Ala Gly Thr Leu Thr Lys Lys Trp His Met Ala Tyr His Gly Ser Asn
                1365                1370                1375    
Val Ala Ala Val Arg Arg Val Leu Asp Arg Gly Glu Leu Gly Ala Gly
            1380                1385                1390        
Thr Ala Ser Ile Leu Ser Cys Arg Pro Leu Lys Gly Glu Pro Gly Val
        1395                1400                1405            
Gly Phe Glu Glu Pro Gly Glu Asn Cys Ala Pro Pro Arg Glu Glu Gln
    1410                1415                1420                
Pro Pro Pro Val Leu Leu Ser Pro Ser Leu Gln Tyr Ala Gly Ala Glu
1425                1430                1435                1440
Thr Leu Ala Ser Lys Val Gln Phe Arg Asp Pro Lys Ser Gln Arg Thr
                1445                1450                1455    
His Gln Ala Gln Val Ala Phe Gln Val Cys Val Arg Pro Gly Ser Tyr
            1460                1465                1470        
Thr Pro Gly Pro Pro Ser Ala Ala Leu Gly Glu Pro Pro Asp Pro His
        1475                1480                1485            
Phe Ser Pro Ala Glu Leu Glu Trp Val Thr Lys Glu Lys Gly Ala Thr
    1490                1495                1500                
Leu Leu Cys Ala Leu Leu Val Arg Val Glu
1505                1510                


<210> 1310
<211> 1086
<212> PRT
<213> Homo sapiens

<400> 1310
Met Ile Ala Val Ser Thr Ala Asn Gly Tyr Ile Leu Phe Phe His Ile
 1               5                  10                  15      
Thr Ser Thr Arg Gly Asp Lys Tyr Leu Tyr Glu Pro Val Tyr Pro Lys
            20                  25                  30          
Gly Ser Pro Gln Met Lys Gly Thr Pro His Phe Lys Glu Glu Gln Cys
        35                  40                  45              
Ala Pro Ala Leu Asn Leu Glu Met Arg Lys Ile Leu Asp Leu Gln Ala
    50                  55                  60                  
Pro Ile Met Ser Leu Gln Ser Val Leu Glu Asp Leu Leu Val Ala Thr
65                  70                  75                  80  
Ser Asp Gly Leu Leu His Leu Ile His Trp Glu Gly Met Thr Asn Gly
                85                  90                  95      
Arg Lys Ala Ile Asn Leu Cys Thr Val Pro Phe Ser Val Asp Leu Gln
            100                 105                 110         
Ser Ser Arg Val Gly Ser Phe Leu Gly Phe Thr Asp Val His Ile Arg
        115                 120                 125             
Asp Met Glu Tyr Cys Ala Thr Leu Asp Gly Phe Ala Val Val Phe Asn
    130                 135                 140                 
Asp Gly Lys Val Gly Phe Ile Thr Pro Val Ser Ser Arg Phe Thr Ala
145                 150                 155                 160 
Glu Gln Leu His Gly Val Trp Pro Gln Asp Val Val Asp Gly Thr Cys
                165                 170                 175     
Val Ala Val Asn Asn Lys Tyr Arg Leu Met Ala Phe Gly Cys Val Ser
            180                 185                 190         
Gly Ser Val Gln Val Tyr Thr Ile Asp Asn Ser Thr Gly Ala Met Leu
        195                 200                 205             
Leu Ser His Lys Leu Glu Leu Thr Ala Lys Gln Tyr Pro Asp Ile Trp
    210                 215                 220                 
Asn Lys Thr Gly Ala Val Lys Leu Met Arg Trp Ser Pro Asp Asn Ser
225                 230                 235                 240 
Val Val Ile Val Thr Trp Glu Tyr Gly Gly Leu Ser Leu Trp Ser Val
                245                 250                 255     
Phe Gly Ala Gln Leu Ile Cys Thr Leu Gly Gly Asp Phe Ala Tyr Arg
            260                 265                 270         
Ser Asp Gly Thr Lys Lys Asp Pro Leu Lys Ile Asn Ser Met Ser Trp
        275                 280                 285             
Gly Ala Glu Gly Tyr His Leu Trp Val Ile Ser Gly Phe Gly Ser Gln
    290                 295                 300                 
Asn Thr Glu Ile Glu Ser Asp Leu Arg Ser Val Val Lys Gln Pro Ser
305                 310                 315                 320 
Ile Leu Leu Phe Gln Phe Ile Lys Ser Val Leu Thr Val Asn Pro Cys
                325                 330                 335     
Met Ser Asn Gln Glu Gln Val Leu Leu Gln Gly Glu Asp Arg Leu Tyr
            340                 345                 350         
Leu Asn Cys Gly Glu Ala Ser Gln Thr Gln Asn Pro Arg Ser Ser Ser
        355                 360                 365             
Thr His Ser Glu His Lys Pro Ser Arg Glu Lys Ser Pro Phe Ala Asp
    370                 375                 380                 
Gly Gly Leu Glu Ser Gln Gly Leu Ser Thr Leu Leu Gly His Arg His
385                 390                 395                 400 
Trp His Val Val Gln Ile Ser Ser Thr Tyr Leu Glu Ser Asn Trp Pro
                405                 410                 415     
Ile Arg Phe Ser Ala Ile Asp Lys Leu Gly Gln Asn Ile Ala Val Val
            420                 425                 430         
Gly Lys Phe Gly Phe Ala His Tyr Ser Leu Leu Thr Lys Lys Trp Lys
        435                 440                 445             
Leu Phe Gly Asn Ile Thr Gln Glu Gln Asn Met Ile Val Thr Gly Gly
    450                 455                 460                 
Leu Ala Trp Trp Asn Asp Phe Met Val Leu Ala Cys Tyr Asn Ile Asn
465                 470                 475                 480 
Asp Arg Gln Glu Glu Leu Arg Val Tyr Leu Arg Thr Ser Asn Leu Asp
                485                 490                 495     
Asn Ala Phe Ala His Val Thr Lys Ala Gln Ala Glu Thr Leu Leu Leu
            500                 505                 510         
Ser Val Phe Gln Asp Met Val Ile Val Phe Arg Ala Asp Cys Ser Ile
        515                 520                 525             
Cys Leu Tyr Ser Ile Glu Arg Lys Ser Asp Gly Pro Asn Thr Thr Ala
    530                 535                 540                 
Gly Ile Gln Val Leu Gln Glu Val Ser Met Ser Arg Tyr Ile Pro His
545                 550                 555                 560 
Pro Phe Leu Val Val Ser Val Thr Leu Thr Ser Val Ser Thr Glu Asn
                565                 570                 575     
Gly Ile Thr Leu Lys Met Pro Gln Gln Ala Arg Gly Ala Glu Ser Ile
            580                 585                 590         
Met Leu Asn Leu Ala Gly Gln Leu Ile Met Met Gln Arg Asp Arg Ser
        595                 600                 605             
Gly Pro Gln Ile Arg Glu Lys Asp Ser Asn Pro Asn Asn Gln Arg Lys
    610                 615                 620                 
Leu Leu Pro Phe Cys Pro Pro Val Val Leu Ala Gln Ser Val Glu Asn
625                 630                 635                 640 
Val Trp Thr Thr Cys Arg Ala Asn Lys Gln Lys Arg His Leu Leu Glu
                645                 650                 655     
Ala Leu Trp Leu Ser Cys Gly Gly Ala Gly Met Lys Val Trp Leu Pro
            660                 665                 670         
Leu Phe Pro Arg Asp His Arg Lys Pro His Ser Phe Leu Ser Gln Arg
        675                 680                 685             
Ile Met Leu Pro Phe His Ile Asn Ile Tyr Pro Leu Ala Val Leu Phe
    690                 695                 700                 
Glu Asp Ala Leu Val Leu Gly Ala Val Asn Asp Thr Leu Leu Tyr Asp
705                 710                 715                 720 
Ser Leu Tyr Thr Arg Asn Asn Ala Arg Glu Gln Leu Glu Val Leu Phe
                725                 730                 735     
Pro Phe Cys Val Val Glu Arg Thr Ser Gln Ile Tyr Leu His His Ile
            740                 745                 750         
Leu Arg Gln Leu Leu Val Arg Asn Leu Gly Glu Gln Ala Leu Leu Leu
        755                 760                 765             
Ala Gln Ser Cys Ala Thr Leu Pro Tyr Phe Pro His Val Leu Glu Leu
    770                 775                 780                 
Met Leu His Glu Val Leu Glu Glu Glu Ala Thr Ser Arg Glu Pro Ile
785                 790                 795                 800 
Pro Asp Pro Leu Leu Pro Thr Val Ala Lys Phe Ile Thr Glu Phe Pro
                805                 810                 815     
Leu Phe Leu Gln Thr Val Val His Cys Ala Arg Lys Thr Glu Tyr Ala
            820                 825                 830         
Leu Trp Asn Tyr Leu Phe Ala Ala Val Gly Asn Pro Lys Asp Leu Phe
        835                 840                 845             
Glu Glu Cys Leu Met Ala Gln Asp Leu Asp Thr Ala Ala Ser Tyr Leu
    850                 855                 860                 
Ile Ile Leu Gln Asn Met Glu Val Pro Ala Val Ser Arg Gln His Ala
865                 870                 875                 880 
Thr Leu Leu Phe Asn Thr Ala Leu Glu Gln Gly Lys Trp Asp Leu Cys
                885                 890                 895     
Arg His Met Ile Arg Phe Leu Lys Ala Ile Gly Ser Gly Glu Ser Glu
            900                 905                 910         
Thr Pro Pro Ser Thr Pro Thr Ala Gln Glu Pro Ser Ser Ser Gly Gly
        915                 920                 925             
Phe Glu Phe Phe Arg Asn Arg Ser Ile Ser Leu Ser Gln Ser Ala Glu
    930                 935                 940                 
Asn Val Pro Ala Ser Lys Phe Ser Leu Gln Lys Thr Leu Ser Met Pro
945                 950                 955                 960 
Ser Gly Pro Ser Gly Lys Arg Trp Ser Lys Asp Ser Asp Cys Ala Glu
                965                 970                 975     
Asn Met Tyr Ile Asp Met Met Leu Trp Arg His Ala Arg Arg Leu Leu
            980                 985                 990         
Glu Asp Val Arg Leu Lys Asp Leu Gly Cys Phe Ala Ala Gln Leu Gly
        995                 1000                1005            
Phe Glu Leu Ile Ser Trp Leu Cys Lys Glu Arg Thr Arg Ala Ala Arg
    1010                1015                1020                
Val Asp Asn Phe Val Ile Ala Leu Lys Arg Leu His Lys Asp Phe Leu
1025                1030                1035                1040
Trp Pro Leu Pro Ile Ile Pro Ala Ser Ser Ile Ser Ser Pro Phe Lys
                1045                1050                1055    
Asn Gly Lys Tyr Arg Thr Gly Asn Val Asp Phe Met Ser Leu Val Gln
            1060                1065                1070        
Gly Glu Leu Tyr Phe Thr Pro Cys Ile Tyr Thr Phe Cys Tyr
        1075                1080                1085    


<210> 1311
<211> 1188
<212> PRT
<213> Homo sapiens

<400> 1311
Met Glu Lys Ala Thr Val Pro Val Ala Ala Ala Thr Ala Ala Glu Gly
 1               5                  10                  15      
Glu Gly Ser Pro Pro Ala Val Ala Ala Val Ala Gly Pro Pro Ala Ala
            20                  25                  30          
Ala Glu Val Gly Gly Gly Val Gly Gly Ser Ser Arg Ala Arg Ser Ala
        35                  40                  45              
Ser Ser Pro Arg Gly Met Val Arg Val Cys Asp Leu Leu Leu Lys Lys
    50                  55                  60                  
Lys Pro Pro Gln Gln Gln His His Lys Ala Lys Arg Asn Arg Thr Cys
65                  70                  75                  80  
Arg Pro Pro Ser Ser Ser Glu Ser Ser Ser Asp Ser Asp Asn Ser Gly
                85                  90                  95      
Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Thr Ser
            100                 105                 110         
Ser Asn Asn Ser Glu Glu Glu Glu Asp Asp Asp Asp Glu Glu Glu Glu
        115                 120                 125             
Val Ser Glu Val Glu Ser Phe Ile Leu Asp Gln Asp Asp Leu Glu Asn
    130                 135                 140                 
Pro Met Leu Glu Thr Ala Ser Lys Leu Leu Leu Ser Gly Thr Ala Asp
145                 150                 155                 160 
Gly Ala Asp Leu Arg Thr Val Asp Pro Glu Thr Gln Ala Arg Leu Glu
                165                 170                 175     
Ala Leu Leu Glu Ala Ala Gly Ile Gly Lys Leu Ser Thr Ala Asp Gly
            180                 185                 190         
Lys Ala Phe Ala Asp Pro Glu Val Leu Arg Arg Leu Thr Ser Ser Val
        195                 200                 205             
Ser Cys Ala Leu Asp Glu Ala Ala Ala Ala Leu Thr Arg Met Arg Ala
    210                 215                 220                 
Glu Ser Thr Ala Asn Ala Gly Gln Ser Asp Asn Arg Ser Leu Ala Glu
225                 230                 235                 240 
Ala Cys Ser Glu Gly Asp Val Asn Ala Val Arg Lys Leu Leu Ile Glu
                245                 250                 255     
Gly Arg Ser Val Asn Glu His Thr Glu Glu Gly Glu Ser Leu Leu Cys
            260                 265                 270         
Leu Ala Cys Ser Ala Gly Tyr Tyr Glu Leu Ala Gln Val Leu Leu Ala
        275                 280                 285             
Met His Ala Asn Val Glu Asp Arg Gly Ile Lys Gly Asp Ile Thr Pro
    290                 295                 300                 
Leu Met Ala Ala Ala Asn Gly Gly His Val Lys Ile Val Lys Leu Leu
305                 310                 315                 320 
Leu Ala His Lys Ala Asp Val Asn Ala Gln Ser Ser Thr Gly Asn Thr
                325                 330                 335     
Ala Leu Thr Tyr Ala Cys Ala Gly Gly Tyr Val Asp Val Val Lys Val
            340                 345                 350         
Leu Leu Glu Ser Gly Ala Ser Ile Glu Asp His Asn Glu Asn Gly His
        355                 360                 365             
Thr Pro Leu Met Glu Ala Gly Ser Ala Gly His Val Glu Val Ala Arg
    370                 375                 380                 
Leu Leu Leu Glu Asn Gly Ala Gly Ile Asn Thr His Ser Asn Glu Phe
385                 390                 395                 400 
Lys Glu Ser Ala Leu Thr Leu Ala Cys Tyr Lys Gly His Leu Glu Met
                405                 410                 415     
Val Arg Phe Leu Leu Glu Ala Gly Ala Asp Gln Glu His Lys Thr Asp
            420                 425                 430         
Glu Met His Thr Ala Leu Met Glu Ala Cys Met Asp Gly His Val Glu
        435                 440                 445             
Val Ala Arg Leu Leu Leu Asp Ser Gly Ala Gln Val Asn Met Pro Ala
    450                 455                 460                 
Asp Ser Phe Glu Ser Pro Leu Thr Leu Ala Ala Cys Gly Gly His Val
465                 470                 475                 480 
Glu Leu Ala Ala Leu Leu Ile Glu Arg Gly Ala Ser Leu Glu Glu Val
                485                 490                 495     
Asn Asp Glu Gly Tyr Thr Pro Leu Met Glu Ala Ala Arg Glu Gly His
            500                 505                 510         
Glu Glu Met Val Ala Leu Leu Leu Gly Gln Gly Ala Asn Ile Asn Ala
        515                 520                 525             
Gln Thr Glu Glu Thr Gln Glu Thr Ala Leu Thr Leu Ala Cys Cys Gly
    530                 535                 540                 
Gly Phe Leu Glu Val Ala Asp Phe Leu Ile Lys Ala Gly Ala Asp Ile
545                 550                 555                 560 
Glu Leu Gly Cys Ser Thr Pro Leu Met Glu Ala Ala Gln Glu Gly His
                565                 570                 575     
Leu Glu Leu Val Lys Tyr Leu Leu Ala Ala Gly Ala Asn Val His Ala
            580                 585                 590         
Thr Thr Ala Thr Gly Asp Thr Ala Leu Thr Tyr Ala Cys Glu Asn Gly
        595                 600                 605             
His Thr Asp Val Ala Asp Val Leu Leu Gln Ala Gly Ala Asp Leu Glu
    610                 615                 620                 
His Glu Ser Glu Gly Gly Arg Thr Pro Leu Met Lys Ala Ala Arg Ala
625                 630                 635                 640 
Gly His Val Cys Thr Val Gln Phe Leu Ile Ser Lys Gly Ala Glu Cys
                645                 650                 655     
Glu Ser Glu Pro Gln Leu Ile Met Thr Ile Leu Ser Ala Leu Ala Cys
            660                 665                 670         
Ala Gly Gly His Leu Ala Val Val Glu Leu Leu Leu Ala His Gly Ala
        675                 680                 685             
Asp Pro Thr His Arg Leu Lys Asp Gly Ser Thr Met Leu Ile Glu Ala
    690                 695                 700                 
Pro Lys Gly Gly His Thr Ser Val Gly Cys Tyr Leu Leu Asp Tyr Pro
705                 710                 715                 720 
Asn Asn Leu Leu Ser Ala Pro Pro Pro Asp Val Thr Gln Leu Thr Pro
                725                 730                 735     
Pro Ser His Asp Leu Asn Arg Ala Pro Arg Val Pro Val Gln Ala Leu
            740                 745                 750         
Pro Met Val Val Pro Pro Gln Glu Pro Asp Lys Pro Pro Ala Asn Val
        755                 760                 765             
Ala Thr Thr Leu Pro Ile Arg Asn Lys Ala Ala Ser Lys Gln Lys Ser
    770                 775                 780                 
Ser Ser His Leu Pro Ala Asn Ser Gln Asp Val Gln Gly Tyr Ile Thr
785                 790                 795                 800 
Asn Gln Ser Pro Glu Ser Ile Val Glu Glu Ala Gln Gly Lys Leu Thr
                805                 810                 815     
Glu Leu Glu Gln Arg Ile Lys Glu Ala Ile Glu Lys Asn Ala Gln Leu
            820                 825                 830         
Gln Ser Leu Glu Leu Ala His Ala Asp Gln Leu Thr Lys Glu Lys Ile
        835                 840                 845             
Glu Glu Leu Asn Lys Thr Arg Glu Glu Gln Ile Gln Lys Lys Gln Lys
    850                 855                 860                 
Ile Leu Glu Glu Leu Gln Lys Val Glu Arg Glu Leu Gln Leu Lys Thr
865                 870                 875                 880 
Gln Gln Gln Leu Lys Lys Gln Tyr Leu Glu Val Lys Ala Gln Arg Ile
                885                 890                 895     
Gln Leu Gln Gln Gln Gln Gln Gln Ser Cys Gln His Leu Gly Leu Leu
            900                 905                 910         
Thr Pro Val Gly Val Gly Glu Gln Leu Ser Glu Gly Asp Tyr Ala Arg
        915                 920                 925             
Leu Gln Gln Val Asp Pro Val Leu Leu Lys Asp Glu Pro Gln Gln Thr
    930                 935                 940                 
Ala Ala Gln Met Gly Phe Ala Pro Ile Gln Pro Leu Ala Met Pro Gln
945                 950                 955                 960 
Ala Leu Pro Leu Ala Ala Gly Pro Leu Pro Pro Gly Ser Ile Ala Asn
                965                 970                 975     
Leu Thr Glu Leu Gln Gly Val Ile Val Gly Gln Pro Val Leu Gly Gln
            980                 985                 990         
Ala Gln Leu Ala Gly Leu Gly Gln Gly Ile Leu Thr Glu Thr Gln Gln
        995                 1000                1005            
Gly Leu Met Val Ala Ser Pro Ala Gln Thr Leu Asn Asp Thr Leu Asp
    1010                1015                1020                
Asp Ile Met Ala Ala Val Ser Gly Arg Ala Ser Ala Met Ser Asn Thr
1025                1030                1035                1040
Pro Thr His Ser Ile Ala Ala Ser Ile Ser Gln Pro Gln Thr Pro Thr
                1045                1050                1055    
Pro Ser Pro Ile Ile Ser Pro Ser Ala Met Leu Pro Ile Tyr Pro Ala
            1060                1065                1070        
Ile Asp Ile Asp Ala Gln Thr Glu Ser Asn His Asp Thr Ala Leu Thr
        1075                1080                1085            
Leu Ala Cys Ala Gly Gly His Glu Glu Leu Val Gln Thr Leu Leu Glu
    1090                1095                1100                
Arg Gly Ala Ser Ile Glu His Arg Asp Lys Lys Gly Phe Thr Pro Leu
1105                1110                1115                1120
Ile Leu Ala Ala Thr Ser Trp Ser Cys Trp Cys Cys Gly Asn Ile Ala
                1125                1130                1135    
Gly Gln Trp Cys Ser Thr Leu Lys Pro Ser Leu Lys Glu Pro Arg Thr
            1140                1145                1150        
His His Ser Pro Trp Leu Val Leu Gly Glu Asp Arg Arg Trp Leu Glu
        1155                1160                1165            
Leu Leu Leu Gly Ser Arg Gly Gln Leu Gln Glu His Arg Lys Val Leu
    1170                1175                1180                
Ile Thr His Leu
1185            


<210> 1312
<211> 43
<212> PRT
<213> Homo sapiens

<400> 1312
Ala His Gly Pro Gly Val Glu Pro Thr Ser Arg His Gln Lys Asn Asn
 1               5                  10                  15      
Leu Ser Ser Ser His Thr Val Arg Leu Glu Thr Arg Gly Gln Thr Glu
            20                  25                  30          
Asn Gln Glu Cys Leu Leu Cys Pro His Glu Glu
        35                  40              


<210> 1313
<211> 1917
<212> PRT
<213> Homo sapiens

<400> 1313
Leu Glu Leu Ile Glu Lys Leu Leu Gln Asn Arg Ile Thr Ile Val Asp
 1               5                  10                  15      
Arg Phe Leu Asn Ser Ser Asn Asp His Arg Phe Gln Ala Leu Gln Asp
            20                  25                  30          
Asn Cys Lys Lys Ile Leu Gly Glu Asn Ala Lys Pro Asn Tyr Gly Cys
        35                  40                  45              
Gln Val Thr Ile Gln Ser Glu Gln Glu Lys Gln Leu Met Lys Gln Tyr
    50                  55                  60                  
Arg Arg Glu Glu Lys Arg Ile Ala Arg Arg Glu Lys Lys Ala Gly Glu
65                  70                  75                  80  
Asp Leu Glu Val Ser Glu Gly Leu Met Cys Phe Asp Pro Lys Glu Leu
                85                  90                  95      
Arg Ile Gln Arg Glu Gln Ala Leu Leu Asn Ala Arg Ser Val Pro Ile
            100                 105                 110         
Leu Ser Arg Gln Arg Asp Ala Asp Val Glu Lys Ile His Tyr Pro His
        115                 120                 125             
Val Tyr Asp Ser Gln Ala Glu Ala Met Lys Thr Ser Ala Phe Ile Ala
    130                 135                 140                 
Gly Ala Lys Met Ile Leu Pro Glu Gly Ile Gln Arg Glu Asn Asn Lys
145                 150                 155                 160 
Leu Tyr Glu Glu Val Arg Ile Pro Tyr Ser Glu Pro Met Pro Leu Ser
                165                 170                 175     
Phe Glu Glu Lys Pro Val Tyr Ile Gln Asp Leu Asp Glu Ile Gly Gln
            180                 185                 190         
Leu Ala Phe Lys Gly Met Lys Arg Leu Asn Arg Ile Gln Ser Ile Val
        195                 200                 205             
Phe Glu Thr Ala Tyr Asn Thr Asn Glu Asn Met Leu Ile Cys Ala Pro
    210                 215                 220                 
Thr Gly Ala Gly Lys Thr Asn Ile Ala Met Leu Thr Val Leu His Glu
225                 230                 235                 240 
Ile Arg Gln His Phe Gln Gln Gly Val Ile Lys Lys Asn Glu Phe Lys
                245                 250                 255     
Ile Val Tyr Val Ala Pro Met Lys Ala Leu Ala Ala Glu Met Thr Asp
            260                 265                 270         
Tyr Phe Ser Arg Arg Leu Glu Pro Leu Gly Ile Ile Val Lys Glu Leu
        275                 280                 285             
Thr Gly Asp Met Gln Leu Ser Lys Ser Glu Ile Leu Arg Thr Gln Met
    290                 295                 300                 
Leu Val Thr Thr Pro Glu Lys Trp Asp Val Val Thr Arg Lys Ser Val
305                 310                 315                 320 
Gly Asp Val Ala Leu Ser Gln Ile Val Arg Leu Leu Ile Leu Asp Glu
                325                 330                 335     
Val His Leu Leu His Glu Asp Arg Gly Pro Val Leu Glu Ser Ile Val
            340                 345                 350         
Ala Arg Thr Leu Arg Gln Val Glu Ser Thr Gln Ser Met Ile Arg Ile
        355                 360                 365             
Leu Gly Leu Ser Ala Thr Leu Pro Asn Tyr Leu Asp Val Ala Thr Phe
    370                 375                 380                 
Leu His Val Asn Pro Tyr Ile Gly Leu Phe Phe Phe Asp Gly Arg Phe
385                 390                 395                 400 
Arg Pro Val Pro Leu Gly Gln Thr Phe Leu Gly Ile Lys Cys Ala Asn
                405                 410                 415     
Lys Met Gln Gln Leu Asn Asn Met Asp Glu Val Cys Tyr Glu Asn Val
            420                 425                 430         
Leu Lys Gln Val Lys Ala Gly His Gln Val Met Val Phe Val His Ala
        435                 440                 445             
Arg Asn Ala Thr Val Arg Thr Ala Met Ser Leu Ile Glu Arg Ala Lys
    450                 455                 460                 
Asn Cys Gly His Ile Pro Phe Phe Phe Pro Thr Gln Gly His Asp Tyr
465                 470                 475                 480 
Val Leu Ala Glu Lys Gln Val Gln Arg Ser Arg Asn Lys Gln Val Arg
                485                 490                 495     
Glu Leu Phe Pro Asp Gly Phe Ser Ile His His Ala Gly Met Leu Arg
            500                 505                 510         
Gln Asp Arg Asn Leu Val Glu Asn Leu Phe Ser Asn Gly His Ile Lys
        515                 520                 525             
Val Leu Val Cys Thr Ala Thr Leu Ala Trp Gly Val Asn Leu Pro Ala
    530                 535                 540                 
His Ala Val Ile Ile Lys Gly Thr Gln Ile Tyr Ala Ala Lys Arg Gly
545                 550                 555                 560 
Ser Phe Val Asp Leu Gly Ile Leu Asp Val Met Gln Ile Phe Gly Arg
                565                 570                 575     
Ala Gly Arg Pro Gln Phe Asp Lys Phe Gly Glu Gly Ile Ile Ile Thr
            580                 585                 590         
Thr His Asp Lys Leu Ser His Tyr Leu Thr Leu Leu Thr Gln Arg Asn
        595                 600                 605             
Pro Ile Glu Ser Gln Phe Leu Glu Ser Leu Ala Asp Asn Leu Asn Ala
    610                 615                 620                 
Glu Ile Ala Leu Gly Thr Val Thr Asn Val Glu Glu Ala Val Lys Trp
625                 630                 635                 640 
Ile Ser Tyr Thr Tyr Leu Tyr Val Arg Met Arg Ala Asn Pro Leu Ala
                645                 650                 655     
Tyr Gly Ile Ser His Lys Ala Tyr Gln Ile Asp Pro Thr Leu Arg Lys
            660                 665                 670         
His Arg Glu Gln Leu Val Ile Glu Val Gly Arg Lys Leu Asp Lys Ala
        675                 680                 685             
Gln Met Ile Arg Phe Glu Glu Arg Thr Gly Tyr Phe Ser Ser Thr Asp
    690                 695                 700                 
Leu Gly Arg Thr Ala Ser His Tyr Tyr Ile Lys Tyr Asn Thr Ile Glu
705                 710                 715                 720 
Thr Phe Asn Glu Leu Phe Asp Ala His Lys Thr Glu Gly Asp Ile Phe
                725                 730                 735     
Ala Ile Val Ser Lys Ala Glu Glu Phe Asp Gln Ile Lys Val Arg Glu
            740                 745                 750         
Glu Glu Ile Glu Glu Leu Asp Thr Leu Leu Ser Asn Phe Cys Glu Leu
        755                 760                 765             
Ser Thr Pro Gly Gly Val Glu Asn Ser Tyr Gly Lys Ile Asn Ile Leu
    770                 775                 780                 
Leu Gln Thr Tyr Ile Ser Arg Gly Glu Met Asp Ser Phe Ser Leu Ile
785                 790                 795                 800 
Ser Asp Ser Ala Tyr Val Ala Gln Asn Ala Ala Arg Ile Val Arg Ala
                805                 810                 815     
Leu Phe Glu Ile Ala Leu Arg Lys Arg Trp Pro Thr Met Thr Tyr Arg
            820                 825                 830         
Leu Leu Asn Leu Ser Lys Val Ile Asp Lys Arg Leu Trp Gly Trp Ala
        835                 840                 845             
Ser Pro Leu Arg Gln Phe Ser Ile Leu Pro Pro His Ile Leu Thr Arg
    850                 855                 860                 
Leu Glu Glu Lys Lys Leu Thr Val Asp Lys Leu Lys Asp Met Arg Lys
865                 870                 875                 880 
Asp Glu Ile Gly His Ile Leu His His Val Asn Ile Gly Leu Lys Val
                885                 890                 895     
Lys Gln Cys Val His Gln Ile Pro Ser Val Met Met Glu Ala Ser Ile
            900                 905                 910         
Gln Pro Ile Thr Arg Thr Val Leu Arg Val Thr Leu Ser Ile Tyr Ala
        915                 920                 925             
Asp Phe Thr Trp Asn Asp Gln Val His Gly Thr Val Gly Glu Pro Trp
    930                 935                 940                 
Trp Ile Trp Val Glu Asp Pro Thr Asn Asp His Ile Tyr His Ser Glu
945                 950                 955                 960 
Tyr Phe Leu Ala Leu Lys Lys Gln Val Ile Ser Lys Glu Ala Gln Leu
                965                 970                 975     
Leu Val Phe Thr Ile Pro Ile Phe Glu Pro Leu Pro Ser Gln Tyr Tyr
            980                 985                 990         
Ile Arg Ala Val Ser Asp Arg Trp Leu Gly Ala Glu Ala Val Cys Ile
        995                 1000                1005            
Ile Asn Phe Gln His Leu Ile Leu Pro Glu Arg His Pro Pro His Thr
    1010                1015                1020                
Glu Leu Leu Asp Leu Gln Pro Leu Pro Ile Thr Ala Leu Gly Cys Lys
1025                1030                1035                1040
Ala Tyr Glu Ala Leu Tyr Asn Phe Ser His Phe Asn Pro Val Gln Thr
                1045                1050                1055    
Gln Ile Phe His Thr Leu Tyr His Thr Asp Cys Asn Val Leu Leu Gly
            1060                1065                1070        
Ala Pro Thr Gly Ser Gly Lys Thr Val Ala Ala Glu Leu Ala Ile Phe
        1075                1080                1085            
Arg Val Phe Asn Lys Tyr Pro Thr Ser Lys Ala Val Tyr Ile Ala Pro
    1090                1095                1100                
Leu Lys Ala Leu Val Arg Glu Arg Met Asp Asp Trp Lys Val Arg Ile
1105                1110                1115                1120
Glu Glu Lys Leu Gly Lys Lys Val Ile Glu Leu Thr Gly Asp Val Thr
                1125                1130                1135    
Pro Asp Met Lys Ser Ile Ala Lys Ala Asp Leu Ile Val Thr Thr Pro
            1140                1145                1150        
Glu Lys Trp Asp Gly Val Ser Arg Ser Trp Gln Asn Arg Asn Tyr Val
        1155                1160                1165            
Gln Gln Val Thr Ile Leu Ile Ile Asp Glu Ile His Leu Leu Gly Glu
    1170                1175                1180                
Glu Arg Gly Pro Val Leu Glu Val Ile Val Ser Arg Thr Asn Phe Ile
1185                1190                1195                1200
Ser Ser His Thr Glu Lys Pro Val Arg Ile Val Gly Leu Ser Thr Ala
                1205                1210                1215    
Leu Ala Asn Ala Arg Asp Leu Ala Asp Trp Leu Asn Ile Lys Gln Met
            1220                1225                1230        
Gly Leu Phe Asn Phe Arg Pro Ser Val Arg Pro Val Pro Leu Glu Val
        1235                1240                1245            
His Ile Gln Gly Phe Pro Gly Gln His Tyr Cys Pro Arg Met Ala Ser
    1250                1255                1260                
Met Asn Lys Pro Ala Phe Gln Ala Ile Arg Ser His Ser Pro Ala Lys
1265                1270                1275                1280
Pro Val Leu Ile Phe Val Ser Ser Arg Arg Gln Thr Arg Leu Thr Ala
                1285                1290                1295    
Leu Glu Leu Ile Ala Phe Leu Ala Thr Glu Glu Asp Pro Lys Gln Trp
            1300                1305                1310        
Leu Asn Met Asp Glu Arg Glu Met Glu Asn Ile Ile Ala Thr Val Arg
        1315                1320                1325            
Asp Ser Asn Leu Lys Leu Thr Leu Ala Phe Gly Ile Gly Met His His
    1330                1335                1340                
Ala Gly Leu His Glu Arg Asp Arg Lys Thr Val Glu Glu Leu Phe Val
1345                1350                1355                1360
Asn Cys Lys Val Gln Val Leu Ile Ala Thr Ser Thr Leu Ala Trp Gly
                1365                1370                1375    
Val Asn Phe Pro Ala His Leu Val Ile Ile Lys Gly Thr Glu Tyr Tyr
            1380                1385                1390        
Asp Gly Lys Thr Arg Arg Tyr Val Asp Phe Pro Ile Thr Asp Val Leu
        1395                1400                1405            
Gln Met Met Gly Arg Ala Gly Arg Pro Gln Phe Asp Asp Gln Gly Lys
    1410                1415                1420                
Ala Val Ile Leu Val His Asp Ile Lys Lys Asp Phe Tyr Lys Lys Phe
1425                1430                1435                1440
Leu Tyr Glu Pro Phe Pro Val Glu Ser Ser Leu Leu Gly Val Leu Ser
                1445                1450                1455    
Asp His Leu Asn Ala Glu Ile Ala Gly Gly Thr Ile Thr Ser Lys Gln
            1460                1465                1470        
Asp Ala Leu Asp Tyr Ile Thr Trp Thr Tyr Phe Phe Arg Arg Leu Ile
        1475                1480                1485            
Met Asn Pro Ser Tyr Tyr Asn Leu Gly Asp Val Ser His Asp Ser Val
    1490                1495                1500                
Asn Lys Phe Leu Ser His Leu Ile Glu Lys Ser Leu Ile Glu Leu Glu
1505                1510                1515                1520
Leu Ser Tyr Cys Ile Glu Ile Gly Glu Asp Asn Arg Ser Ile Glu Pro
                1525                1530                1535    
Leu Thr Tyr Gly Arg Ile Ala Ser Tyr Tyr Tyr Leu Lys His Gln Thr
            1540                1545                1550        
Val Lys Met Phe Lys Asp Arg Leu Lys Pro Glu Cys Ser Thr Glu Glu
        1555                1560                1565            
Leu Leu Ser Ile Leu Ser Asp Ala Glu Glu Tyr Thr Asp Leu Pro Val
    1570                1575                1580                
Arg His Asn Glu Asp His Met Asn Ser Glu Leu Ala Lys Cys Leu Pro
1585                1590                1595                1600
Ile Glu Ser Asn Pro His Ser Phe Asp Ser Pro His Thr Lys Ala His
                1605                1610                1615    
Leu Leu Leu Gln Ala His Leu Ser Arg Ala Met Leu Pro Cys Pro Asp
            1620                1625                1630        
Tyr Asp Thr Asp Thr Lys Thr Val Leu Asp Gln Ala Leu Arg Val Cys
        1635                1640                1645            
Gln Ala Met Leu Asp Val Ala Ala Asn Gln Gly Trp Leu Val Thr Val
    1650                1655                1660                
Leu Asn Ile Thr Asn Leu Ile Gln Met Val Ile Gln Gly Arg Trp Leu
1665                1670                1675                1680
Lys Asp Ser Ser Leu Leu Thr Leu Pro Asn Ile Glu Asn His His Leu
                1685                1690                1695    
His Leu Phe Lys Lys Trp Lys Pro Ile Met Lys Gly Pro His Ala Arg
            1700                1705                1710        
Gly Arg Thr Ser Ile Glu Cys Leu Pro Glu Leu Ile His Ala Cys Gly
        1715                1720                1725            
Gly Lys Asp His Val Phe Ser Ser Met Val Glu Ser Glu Leu His Ala
    1730                1735                1740                
Ala Lys Thr Lys Gln Ala Trp Asn Phe Leu Ser His Leu Pro Val Ile
1745                1750                1755                1760
Asn Val Gly Ile Ser Val Lys Gly Ser Trp Asp Asp Leu Val Glu Gly
                1765                1770                1775    
His Asn Glu Leu Ser Val Ser Thr Leu Thr Ala Asp Lys Arg Asp Asp
            1780                1785                1790        
Asn Lys Trp Ile Lys Leu His Ala Asp Gln Glu Tyr Val Leu Gln Val
        1795                1800                1805            
Ser Leu Gln Arg Val His Phe Gly Phe His Lys Gly Lys Pro Glu Ser
    1810                1815                1820                
Cys Ala Val Thr Pro Arg Phe Pro Lys Ser Lys Asp Glu Gly Trp Phe
1825                1830                1835                1840
Leu Ile Leu Gly Glu Val Asp Lys Arg Glu Leu Ile Ala Leu Lys Arg
                1845                1850                1855    
Val Gly Tyr Ile Arg Asn His His Val Ala Ser Leu Ser Phe Tyr Thr
            1860                1865                1870        
Pro Glu Ile Pro Gly Arg Tyr Ile Tyr Thr Leu Tyr Phe Met Ser Asp
        1875                1880                1885            
Cys Tyr Leu Gly Leu Asp Gln Gln Tyr Asp Asn Leu Ser Gln Arg Tyr
    1890                1895                1900                
Thr Ser Glu Ser Phe Cys Thr Gly Gln His Gln Gly Leu
1905                1910                1915        


<210> 1314
<211> 930
<212> PRT
<213> Homo sapiens

<400> 1314
Met Pro Arg Ala Pro His Phe Met Pro Leu Leu Leu Leu Leu Leu Leu
 1               5                  10                  15      
Leu Ser Leu Pro His Thr Gln Ala Ala Phe Pro Gln Asp Pro Leu Pro
            20                  25                  30          
Leu Leu Ile Ser Asp Leu Gln Gly Thr Ser Pro Leu Ser Trp Phe Arg
        35                  40                  45              
Gly Leu Glu Asp Asp Ala Val Ala Ala Glu Leu Gly Leu Asp Phe Gln
    50                  55                  60                  
Arg Phe Leu Thr Leu Asn Arg Thr Leu Leu Val Ala Ala Arg Asp His
65                  70                  75                  80  
Val Phe Ser Phe Asp Leu Gln Ala Glu Glu Glu Gly Glu Gly Leu Val
                85                  90                  95      
Pro Asn Lys Tyr Leu Thr Trp Arg Ser Gln Asp Val Glu Asn Cys Ala
            100                 105                 110         
Val Arg Gly Lys Leu Thr Asp Glu Cys Tyr Asn Tyr Ile Arg Val Leu
        115                 120                 125             
Val Pro Trp Asp Ser Gln Thr Leu Leu Ala Cys Gly Thr Asn Ser Phe
    130                 135                 140                 
Ser Pro Val Cys Arg Ser Tyr Gly Ile Thr Ser Leu Gln Gln Glu Gly
145                 150                 155                 160 
Glu Glu Leu Ser Gly Gln Ala Arg Cys Pro Phe Asp Ala Thr Gln Ser
                165                 170                 175     
Asn Val Ala Ile Phe Ala Glu Gly Ser Leu Tyr Ser Ala Thr Ala Ala
            180                 185                 190         
Asp Phe Gln Ala Ser Asp Ala Val Val Tyr Arg Ser Leu Gly Pro Gln
        195                 200                 205             
Pro Pro Leu Arg Ser Ala Lys Tyr Asp Ser Lys Trp Leu Arg Glu Pro
    210                 215                 220                 
His Phe Val Gln Ala Leu Glu His Gly Asp His Val Tyr Phe Phe Phe
225                 230                 235                 240 
Arg Glu Val Ser Val Glu Asp Ala Arg Leu Gly Lys Val Gln Phe Ser
                245                 250                 255     
Arg Val Ala Arg Val Cys Lys Arg Asp Met Gly Gly Ser Pro Arg Ala
            260                 265                 270         
Leu Asp Arg His Trp Thr Ser Phe Leu Lys Leu Arg Leu Asn Cys Ser
        275                 280                 285             
Val Pro Gly Asp Ser Thr Phe Tyr Phe Asp Val Leu Gln Ala Leu Thr
    290                 295                 300                 
Gly Pro Val Asn Leu His Gly Arg Ser Ala Leu Phe Gly Val Phe Thr
305                 310                 315                 320 
Thr Gln Thr Asn Ser Ile Pro Gly Ser Ala Val Cys Ala Phe Tyr Leu
                325                 330                 335     
Asp Glu Ile Glu Arg Gly Phe Glu Gly Lys Phe Lys Glu Gln Arg Ser
            340                 345                 350         
Leu Asp Gly Ala Trp Thr Pro Val Ser Glu Asp Arg Val Pro Ser Pro
        355                 360                 365             
Arg Pro Gly Ser Cys Ala Gly Val Gly Gly Ala Ala Leu Phe Ser Ser
    370                 375                 380                 
Ser Arg Asp Leu Pro Asp Asp Val Leu Thr Phe Ile Lys Ala His Pro
385                 390                 395                 400 
Leu Leu Asp Pro Ala Val Pro Pro Val Thr His Gln Pro Leu Leu Thr
                405                 410                 415     
Leu Thr Ser Arg Ala Leu Leu Thr Gln Val Ala Val Asp Gly Met Ala
            420                 425                 430         
Gly Pro His Ser Asn Ile Thr Val Met Phe Leu Gly Ser Asn Asp Gly
        435                 440                 445             
Thr Val Leu Lys Val Leu Thr Pro Gly Gly Arg Ser Gly Gly Pro Glu
    450                 455                 460                 
Pro Ile Leu Leu Glu Glu Ile Asp Ala Tyr Ser Pro Ala Arg Cys Ser
465                 470                 475                 480 
Gly Lys Arg Thr Ala Gln Thr Ala Arg Arg Ile Ile Gly Leu Glu Leu
                485                 490                 495     
Asp Thr Glu Gly His Arg Leu Phe Val Ala Phe Ser Gly Cys Ile Val
            500                 505                 510         
Tyr Leu Pro Leu Ser Arg Cys Ala Arg His Gly Ala Cys Gln Arg Ser
        515                 520                 525             
Cys Leu Ala Ser Gln Asp Pro Tyr Cys Gly Trp His Ser Ser Arg Gly
    530                 535                 540                 
Cys Val Asp Ile Arg Gly Ser Gly Gly Thr Asp Val Asp Gln Ala Gly
545                 550                 555                 560 
Asn Gln Glu Ser Met Glu His Gly Asp Cys Gln Asp Gly Ala Thr Gly
                565                 570                 575     
Ser Gln Ser Gly Pro Gly Asp Ser Ala Tyr Gly Val Arg Arg Asp Leu
            580                 585                 590         
Pro Pro Ala Ser Ala Ser Arg Ser Val Pro Ile Pro Leu Leu Leu Ala
        595                 600                 605             
Ser Val Ala Ala Ala Phe Ala Leu Gly Ala Ser Val Ser Gly Leu Leu
    610                 615                 620                 
Val Ser Cys Ala Cys Arg Arg Ala His Arg Arg Arg Gly Lys Asp Ile
625                 630                 635                 640 
Glu Thr Pro Gly Leu Pro Arg Pro Leu Ser Leu Arg Ser Leu Ala Arg
                645                 650                 655     
Leu His Gly Gly Gly Pro Glu Pro Pro Pro Pro Ser Lys Asp Gly Asp
            660                 665                 670         
Ala Val Gln Thr Pro Gln Leu Tyr Thr Thr Phe Leu Pro Pro Pro Glu
        675                 680                 685             
Gly Val Pro Pro Pro Glu Leu Ala Cys Leu Pro Thr Pro Glu Ser Thr
    690                 695                 700                 
Pro Glu Leu Pro Val Lys His Leu Arg Ala Ala Gly Asp Pro Trp Glu
705                 710                 715                 720 
Trp Asn Gln Asn Arg Asn Asn Ala Lys Glu Gly Pro Gly Arg Ser Arg
                725                 730                 735     
Gly Gly His Ala Ala Gly Gly Pro Ala Pro Arg Val Leu Val Arg Pro
            740                 745                 750         
Pro Pro Pro Gly Cys Pro Gly Gln Ala Val Glu Val Thr Thr Leu Glu
        755                 760                 765             
Glu Leu Leu Arg Tyr Leu His Gly Pro Gln Pro Pro Arg Lys Gly Ala
    770                 775                 780                 
Glu Pro Pro Ala Pro Leu Thr Ser Arg Ala Leu Pro Pro Glu Pro Ala
785                 790                 795                 800 
Pro Ala Leu Leu Gly Gly Pro Ser Pro Arg Pro His Glu Cys Ala Ser
                805                 810                 815     
Pro Leu Arg Leu Asp Val Pro Pro Glu Gly Arg Cys Ala Ser Ala Pro
            820                 825                 830         
Ala Arg Pro Ala Leu Ser Ala Pro Ala Pro Arg Leu Gly Val Gly Gly
        835                 840                 845             
Gly Arg Arg Leu Pro Phe Ser Gly His Arg Ala Pro Pro Ala Leu Leu
    850                 855                 860                 
Thr Arg Val Pro Ser Gly Gly Pro Ser Arg Tyr Ser Gly Gly Pro Gly
865                 870                 875                 880 
Lys His Leu Leu Tyr Leu Gly Arg Pro Glu Gly Tyr Arg Gly Arg Ala
                885                 890                 895     
Leu Lys Arg Val Asp Val Glu Lys Pro Gln Leu Ser Leu Lys Pro Pro
            900                 905                 910         
Leu Val Gly Pro Ser Ser Arg Gln Ala Val Pro Asn Gly Gly Arg Phe
        915                 920                 925             
Asn Phe
    930 


<210> 1315
<211> 163
<212> PRT
<213> Homo sapiens

<400> 1315
Met Asn Pro Glu Tyr Asp Tyr Leu Phe Lys Leu Leu Leu Ile Gly Asp
 1               5                  10                  15      
Ser Gly Val Gly Lys Ser Cys Leu Leu Leu Arg Phe Ala Asp Asp Thr
            20                  25                  30          
Tyr Thr Glu Ser Tyr Ile Ser Thr Ile Gly Val Asp Phe Lys Ile Arg
        35                  40                  45              
Thr Ile Glu Leu Asp Gly Lys Thr Ile Lys Leu Gln Ile Trp Asp Thr
    50                  55                  60                  
Ala Gly Gln Glu Arg Phe Arg Thr Ile Thr Ser Ser Tyr Tyr Arg Gly
65                  70                  75                  80  
Ala His Gly Ile Ile Val Val Tyr Asp Val Thr Asp Gln Glu Ser Tyr
                85                  90                  95      
Ala Asn Val Lys Gln Val Ala Ala Gly Arg Leu Thr Ala Met Pro Ala
            100                 105                 110         
Arg Thr Ser Ile Ser Ser Trp Trp Ala Thr Arg Ala Thr Ser Pro Pro
        115                 120                 125             
Arg Arg Trp Trp Thr Thr Pro Gln Pro Arg Ser Leu Gln Thr Leu Trp
    130                 135                 140                 
Ala Ser Pro Ser Trp Arg Arg Ala Pro Arg Met Pro Pro Met Ser Ser
145                 150                 155                 160 
Arg Arg Ser
            


<210> 1316
<211> 505
<212> PRT
<213> Homo sapiens

<400> 1316
Met Thr Ser Ser Leu Tyr Phe Ile Thr Phe Gly Met Gly Ala Ser Pro
 1               5                  10                  15      
Phe Thr Asn Ile Glu Ala Val Lys Val Phe Cys Gln Asn Met Cys Val
            20                  25                  30          
Ser Ile Leu Leu Asn Tyr Phe Tyr Ile Phe Ser Phe Phe Gly Ser Cys
        35                  40                  45              
Leu Val Phe Ala Gly Gln Leu Glu Gln Asn Arg Tyr His Ser Ile Phe
    50                  55                  60                  
Cys Cys Lys Ile Pro Ser Ala Glu Tyr Leu Asp Arg Lys Pro Val Trp
65                  70                  75                  80  
Phe Gln Thr Val Met Ser Asp Gly His Gln Gln Thr Ser His His Glu
                85                  90                  95      
Thr Asn Pro Tyr Gln His His Phe Ile Gln His Phe Leu Arg Glu His
            100                 105                 110         
Tyr Asn Glu Trp Ile Thr Asn Ile Tyr Val Lys Pro Phe Val Val Ile
        115                 120                 125             
Leu Tyr Leu Ile Tyr Ala Ser Phe Ser Phe Met Gly Cys Leu Gln Ile
    130                 135                 140                 
Ser Asp Gly Ala Asn Ile Ile Asn Leu Leu Ala Ser Asp Ser Pro Ser
145                 150                 155                 160 
Val Ser Tyr Ala Met Val Gln Gln Lys Tyr Phe Ser Asn Tyr Ser Pro
                165                 170                 175     
Val Ile Gly Phe Tyr Val Tyr Glu Pro Leu Glu Tyr Trp Asn Ser Ser
            180                 185                 190         
Val Gln Asp Asp Leu Arg Arg Leu Cys Ser Gly Phe Thr Ala Val Ser
        195                 200                 205             
Trp Val Glu Gln Tyr Tyr Gln Phe Leu Lys Val Ser Asn Val Ser Ala
    210                 215                 220                 
Asn Asn Lys Ser Asp Phe Ile Ser Val Leu Gln Ser Ser Phe Leu Lys
225                 230                 235                 240 
Lys Pro Glu Phe Gln His Phe Arg Asn Asp Ile Ile Phe Ser Lys Ala
                245                 250                 255     
Gly Asp Glu Ser Asn Ile Ile Ala Ser Arg Leu Tyr Leu Val Ala Arg
            260                 265                 270         
Thr Ser Arg Asp Lys Gln Lys Glu Ile Thr Glu Val Leu Glu Lys Leu
        275                 280                 285             
Arg Pro Leu Ser Leu Ser Lys Ser Ile Arg Phe Ile Val Phe Asn Pro
    290                 295                 300                 
Ser Phe Val Phe Met Asp His Tyr Ser Leu Ser Val Thr Val Pro Val
305                 310                 315                 320 
Leu Ile Ala Gly Phe Gly Val Leu Leu Val Leu Ile Leu Thr Phe Phe
                325                 330                 335     
Leu Val Ile His Pro Leu Gly Asn Phe Trp Leu Ile Leu Ser Val Thr
            340                 345                 350         
Ser Ile Glu Leu Gly Val Leu Gly Leu Met Thr Leu Trp Asn Val Asp
        355                 360                 365             
Met Asp Cys Ile Ser Ile Leu Cys Leu Ile Tyr Thr Leu Asn Phe Ala
    370                 375                 380                 
Ile Asp His Cys Ala Pro Leu Leu Phe Thr Phe Val Leu Ala Thr Glu
385                 390                 395                 400 
His Thr Arg Thr Gln Cys Ile Lys Ser Ser Leu Gln Asp His Gly Thr
                405                 410                 415     
Ala Ile Leu Gln Asn Val Thr Ser Phe Leu Ile Gly Leu Val Pro Leu
            420                 425                 430         
Leu Phe Val Pro Ser Asn Leu Thr Phe Thr Leu Phe Lys Cys Leu Leu
        435                 440                 445             
Leu Thr Gly Gly Cys Thr Leu Leu His Cys Phe Val Ile Leu Pro Val
    450                 455                 460                 
Phe Leu Thr Phe Phe Pro Pro Ser Lys Lys His His Lys Lys Lys Lys
465                 470                 475                 480 
Arg Ala Lys Arg Lys Glu Arg Glu Glu Ile Glu Cys Ile Glu Ile Gln
                485                 490                 495     
Glu Asn Pro Asp His Val Thr Thr Val
            500                 505 


<210> 1317
<211> 146
<212> PRT
<213> Homo sapiens

<400> 1317
Met Ala Thr Ala Glu Ala Ser Gly Ser Asp Gly Lys Gly Gln Glu Val
 1               5                  10                  15      
Glu Thr Ser Val Thr Tyr Tyr Arg Leu Glu Glu Val Ala Lys Arg Asn
            20                  25                  30          
Ser Leu Lys Glu Leu Trp Leu Val Ile His Gly Arg Val Tyr Asp Val
        35                  40                  45              
Thr Arg Phe Leu Asn Glu His Pro Gly Gly Glu Glu Val Leu Leu Glu
    50                  55                  60                  
Gln Ala Gly Val Asp Ala Ser Glu Ser Phe Glu Asp Val Gly His Ser
65                  70                  75                  80  
Ser Asp Ala Arg Glu Met Leu Lys Gln Tyr Tyr Ile Gly Asp Ile His
                85                  90                  95      
Pro Ser Asp Leu Lys Pro Glu Ser Gly Ser Lys Asp Pro Ser Gln Asn
            100                 105                 110         
Asp Thr Cys Lys Ser Cys Trp Ala Tyr Trp Ile Leu Pro Ile Ile Gly
        115                 120                 125             
Ala Val Leu Leu Gly Phe Leu Tyr Arg Tyr Tyr Thr Ser Glu Ser Lys
    130                 135                 140                 
Ser Ser
145     


<210> 1318
<211> 553
<212> PRT
<213> Homo sapiens

<400> 1318
Met Ala Ala Ser Lys Lys Ala Val Leu Gly Pro Leu Val Gly Ala Val
 1               5                  10                  15      
Asp Gln Gly Thr Ser Ser Thr Arg Phe Leu Val Phe Asn Ser Arg Thr
            20                  25                  30          
Ala Glu Leu Leu Ser His His Gln Val Glu Ile Lys Gln Glu Phe Pro
        35                  40                  45              
Arg Glu Gly Trp Val Glu Gln Asp Pro Lys Glu Ile Leu His Ser Val
    50                  55                  60                  
Tyr Glu Cys Ile Glu Lys Thr Cys Glu Lys Leu Gly Gln Leu Asn Ile
65                  70                  75                  80  
Gly Ile Ser Asn Ile Lys Ala Ile Gly Val Ser Asn Gln Arg Glu Thr
                85                  90                  95      
Thr Val Ala Trp Asp Lys Ile Thr Gly Glu Pro Leu Tyr Asn Ala Val
            100                 105                 110         
Val Trp Leu Asp Leu Arg Thr Gln Ser Thr Val Glu Ser Leu Ser Lys
        115                 120                 125             
Arg Ile Pro Gly Asn Asn Asn Phe Val Lys Ser Lys Thr Gly Leu Pro
    130                 135                 140                 
Leu Ser Thr Tyr Phe Ser Ala Val Lys Leu Arg Trp Leu Leu Asp Asn
145                 150                 155                 160 
Val Arg Lys Val Gln Lys Ala Val Glu Glu Lys Arg Ala Leu Phe Gly
                165                 170                 175     
Thr Ile Asp Ser Trp Leu Ile Trp Ser Leu Thr Gly Gly Val Asn Gly
            180                 185                 190         
Gly Val His Cys Thr Asp Val Thr Asn Ala Ser Arg Thr Met Leu Phe
        195                 200                 205             
Asn Ile His Ser Leu Glu Trp Asp Lys Gln Leu Cys Glu Phe Phe Gly
    210                 215                 220                 
Ile Pro Met Glu Ile Leu Pro His Val Arg Ser Ser Ser Glu Ile Tyr
225                 230                 235                 240 
Gly Leu Met Lys Ala Gly Ala Leu Glu Gly Val Pro Ile Ser Gly Cys
                245                 250                 255     
Leu Gly Asp Gln Ser Ala Ala Leu Val Gly Gln Met Cys Phe Gln Ile
            260                 265                 270         
Gly Gln Ala Lys Asn Thr Tyr Gly Thr Gly Cys Phe Leu Leu Cys Asn
        275                 280                 285             
Thr Gly His Lys Cys Val Phe Ser Asp His Gly Leu Leu Thr Thr Val
    290                 295                 300                 
Ala Tyr Lys Leu Gly Arg Asp Lys Pro Val Tyr Tyr Ala Leu Glu Gly
305                 310                 315                 320 
Ser Val Ala Ile Ala Gly Ala Val Ile Arg Trp Leu Arg Asp Asn Leu
                325                 330                 335     
Gly Ile Ile Lys Thr Ser Glu Glu Ile Glu Lys Leu Ala Lys Glu Val
            340                 345                 350         
Gly Thr Ser Tyr Gly Cys Tyr Phe Val Pro Ala Phe Ser Gly Leu Tyr
        355                 360                 365             
Ala Pro Tyr Trp Glu Pro Ser Ala Arg Gly Ile Ile Cys Gly Leu Thr
    370                 375                 380                 
Gln Phe Thr Asn Lys Cys His Ile Ala Phe Ala Ala Leu Glu Ala Val
385                 390                 395                 400 
Cys Phe Gln Thr Arg Glu Ile Leu Asp Ala Met Asn Arg Asp Cys Gly
                405                 410                 415     
Ile Pro Leu Ser His Leu Gln Val Asp Gly Gly Met Thr Ser Asn Lys
            420                 425                 430         
Ile Leu Met Gln Leu Gln Ala Asp Ile Leu Tyr Ile Pro Val Val Lys
        435                 440                 445             
Pro Leu Met Pro Glu Thr Thr Ala Leu Gly Ala Ala Met Ala Ala Gly
    450                 455                 460                 
Ala Ala Glu Gly Val Asp Val Trp Ser Leu Glu Pro Glu Asp Leu Ser
465                 470                 475                 480 
Ala Val Thr Met Glu Arg Phe Glu Pro Gln Ile Asn Ala Glu Glu Ser
                485                 490                 495     
Glu Ile Arg Tyr Ser Thr Trp Lys Lys Ala Val Met Lys Ser Met Gly
            500                 505                 510         
Trp Val Thr Thr Gln Ser Pro Glu Gly Gly Asp Pro Ser Val Phe Cys
        515                 520                 525             
Ser Leu Pro Leu Gly Phe Phe Ile Val Ser Ser Met Ala Met Leu Ile
    530                 535                 540                 
Gly Ala Arg Tyr Ile Ser Gly Ile Pro
545                 550             


<210> 1319
<211> 997
<212> PRT
<213> Homo sapiens

<400> 1319
Met Asp Asp Gln Pro Gly Glu Lys Glu Leu Val Lys Arg Ser Gln Leu
 1               5                  10                  15      
Asp Gly Glu Gly Asp Gly Pro Leu Ser Asn Gln Leu Ser Ala Ser Ser
            20                  25                  30          
Thr Ile Asn Pro Val Pro Leu Val Gly Leu Gln Lys Pro Glu Met Ser
        35                  40                  45              
Leu Pro Val Lys Pro Gly Gln Gly Asp Ser Glu Ala Ser Ser Pro Phe
    50                  55                  60                  
Thr Pro Val Ala Asp Glu Asp Ser Val Val Phe Ser Lys Leu Thr Tyr
65                  70                  75                  80  
Leu Gly Cys Ala Ser Val Asn Ala Pro Arg Ser Glu Val Glu Ala Leu
                85                  90                  95      
Arg Met Met Ser Ile Leu Arg Ser Gln Cys Gln Ile Ser Leu Asp Val
            100                 105                 110         
Thr Leu Ser Val Pro Asn Val Ser Glu Gly Ile Val Arg Leu Leu Asp
        115                 120                 125             
Pro Gln Thr Asn Thr Glu Ile Ala Asn Tyr Pro Ile Tyr Lys Ile Leu
    130                 135                 140                 
Phe Cys Val Arg Gly His Asp Gly Thr Pro Glu Ser Asp Cys Phe Ala
145                 150                 155                 160 
Phe Thr Glu Ser His Tyr Asn Ala Glu Leu Phe Arg Ile His Val Phe
                165                 170                 175     
Arg Cys Glu Ile Gln Glu Ala Val Ser Arg Ile Leu Tyr Ser Phe Ala
            180                 185                 190         
Thr Ala Phe Arg Arg Ser Ala Lys Gln Thr Pro Leu Ser Ala Thr Ala
        195                 200                 205             
Ala Pro Gln Thr Pro Asp Ser Asp Ile Phe Thr Phe Ser Val Ser Leu
    210                 215                 220                 
Glu Ile Lys Glu Asp Asp Gly Lys Gly Tyr Phe Ser Ala Val Pro Lys
225                 230                 235                 240 
Asp Lys Asp Arg Gln Cys Phe Lys Leu Arg Gln Gly Ile Asp Lys Lys
                245                 250                 255     
Ile Val Ile Tyr Val Gln Gln Thr Thr Asn Lys Glu Leu Ala Ile Glu
            260                 265                 270         
Arg Cys Phe Gly Leu Leu Leu Ser Pro Gly Lys Asp Val Arg Asn Ser
        275                 280                 285             
Asp Met His Leu Leu Asp Leu Glu Ser Met Gly Lys Ser Ser Asp Gly
    290                 295                 300                 
Lys Ser Tyr Val Ile Thr Gly Ser Trp Asn Pro Lys Ser Pro His Phe
305                 310                 315                 320 
Gln Val Val Asn Glu Glu Thr Pro Lys Asp Lys Val Leu Phe Met Thr
                325                 330                 335     
Thr Ala Val Asp Leu Val Ile Thr Glu Val Gln Glu Pro Val Arg Phe
            340                 345                 350         
Leu Leu Glu Thr Lys Val Arg Val Cys Ser Pro Asn Glu Arg Leu Phe
        355                 360                 365             
Trp Pro Phe Ser Lys Arg Ser Thr Thr Glu Asn Phe Phe Leu Lys Leu
    370                 375                 380                 
Lys Gln Ile Lys Gln Arg Glu Arg Lys Asn Asn Thr Asp Thr Leu Tyr
385                 390                 395                 400 
Glu Val Val Cys Leu Glu Ser Glu Ser Glu Arg Glu Arg Arg Lys Thr
                405                 410                 415     
Thr Ala Ser Pro Ser Val Arg Leu Pro Gln Ser Gly Ser Gln Ser Ser
            420                 425                 430         
Val Ile Pro Ser Pro Pro Glu Asp Asp Glu Glu Glu Asp Asn Asp Glu
        435                 440                 445             
Pro Leu Leu Ser Gly Ser Gly Asp Val Ser Lys Glu Cys Ala Glu Lys
    450                 455                 460                 
Ile Leu Glu Thr Trp Gly Glu Leu Leu Ser Lys Trp His Leu Asn Leu
465                 470                 475                 480 
Asn Val Arg Pro Lys Gln Leu Ser Ser Leu Val Arg Asn Gly Val Pro
                485                 490                 495     
Glu Ala Leu Arg Gly Glu Val Trp Gln Leu Leu Ala Gly Cys His Asn
            500                 505                 510         
Asn Asp His Leu Val Glu Lys Tyr Arg Ile Leu Ile Thr Lys Glu Ser
        515                 520                 525             
Pro Gln Asp Ser Ala Ile Thr Arg Asp Ile Asn Arg Thr Phe Pro Ala
    530                 535                 540                 
His Asp Tyr Phe Lys Asp Thr Gly Gly Asp Gly Gln Asp Ser Leu Tyr
545                 550                 555                 560 
Lys Ile Cys Lys Ala Tyr Ser Val Tyr Asp Glu Glu Ile Gly Tyr Cys
                565                 570                 575     
Gln Gly Gln Ser Phe Leu Ala Ala Val Leu Leu Leu His Met Pro Glu
            580                 585                 590         
Glu Gln Ala Phe Ser Val Leu Val Lys Ile Met Phe Asp Tyr Gly Leu
        595                 600                 605             
Arg Glu Leu Phe Lys Gln Asn Phe Glu Asp Leu His Cys Lys Phe Tyr
    610                 615                 620                 
Gln Leu Glu Arg Leu Met Gln Glu Tyr Ile Pro Asp Leu Tyr Asn His
625                 630                 635                 640 
Phe Leu Asp Ile Ser Leu Glu Ala His Met Tyr Ala Ser Gln Trp Phe
                645                 650                 655     
Leu Thr Leu Phe Thr Ala Lys Phe Pro Leu Tyr Met Val Phe His Ile
            660                 665                 670         
Ile Asp Leu Leu Leu Cys Glu Gly Ile Ser Val Ile Phe Asn Val Ala
        675                 680                 685             
Leu Gly Leu Leu Lys Thr Ser Lys Asp Asp Leu Leu Leu Thr Asp Phe
    690                 695                 700                 
Glu Gly Ala Leu Lys Phe Phe Arg Val Gln Leu Pro Lys Arg Tyr Arg
705                 710                 715                 720 
Ser Glu Glu Asn Ala Lys Lys Leu Met Glu Leu Ala Cys Asn Met Lys
                725                 730                 735     
Ile Ser Gln Lys Lys Leu Lys Lys Tyr Glu Lys Glu Tyr His Thr Met
            740                 745                 750         
Arg Glu Gln Gln Ala Gln Gln Glu Asp Pro Ile Glu Arg Phe Glu Arg
        755                 760                 765             
Glu Asn Arg Arg Leu Gln Glu Ala Asn Met Arg Leu Glu Gln Glu Asn
    770                 775                 780                 
Asp Asp Leu Ala His Glu Leu Val Thr Ser Lys Ile Ala Leu Arg Lys
785                 790                 795                 800 
Asp Leu Asp Asn Ala Glu Glu Lys Ala Asp Ala Leu Asn Lys Glu Leu
                805                 810                 815     
Leu Met Thr Lys Gln Lys Leu Ile Asp Ala Glu Glu Glu Lys Arg Arg
            820                 825                 830         
Leu Glu Glu Glu Ser Ala Gln Leu Lys Glu Met Cys Arg Arg Glu Leu
        835                 840                 845             
Asp Lys Ala Glu Ser Glu Ile Lys Lys Asn Ser Ser Ile Ile Gly Asp
    850                 855                 860                 
Tyr Lys Gln Ile Cys Ser Gln Leu Ser Glu Arg Leu Glu Lys Gln Gln
865                 870                 875                 880 
Thr Ala Asn Lys Val Glu Ile Glu Lys Ile Arg Gln Lys Val Asp Asp
                885                 890                 895     
Cys Glu Arg Cys Arg Glu Phe Phe Asn Lys Glu Gly Arg Val Lys Gly
            900                 905                 910         
Ile Ser Ser Thr Lys Glu Val Leu Asp Glu Asp Thr Asp Glu Glu Lys
        915                 920                 925             
Glu Thr Leu Lys Asn Gln Leu Arg Glu Met Glu Leu Glu Leu Ala Gln
    930                 935                 940                 
Thr Lys Leu Gln Leu Val Glu Ala Glu Cys Lys Ile Gln Asp Leu Glu
945                 950                 955                 960 
His His Leu Gly Leu Ala Leu Asn Glu Val Gln Ala Ala Lys Lys Thr
                965                 970                 975     
Trp Phe Asn Arg Thr Leu Ser Ser Ile Lys Thr Ala Thr Gly Val Gln
            980                 985                 990         
Gly Lys Glu Thr Cys
        995         


<210> 1320
<211> 236
<212> PRT
<213> Homo sapiens

<400> 1320
Met Ile Leu Ile Gly Arg Met Ser Ala Gln Val Pro Met Asn Met Thr
 1               5                  10                  15      
Ile Thr Gly Cys Met Met Thr Phe Tyr Arg Thr Thr Pro Ala Val Leu
            20                  25                  30          
Phe Trp Gln Trp Ile Asn Gln Ser Phe Asn Ala Val Val Asn Tyr Thr
        35                  40                  45              
Asn Arg Ser Gly Asp Ala Pro Leu Thr Val Asn Glu Leu Gly Thr Ala
    50                  55                  60                  
Tyr Val Ser Ala Thr Thr Gly Ala Val Ala Thr Ala Leu Gly Leu Asn
65                  70                  75                  80  
Ala Leu Thr Lys His Val Ser Pro Leu Ile Gly Arg Phe Val Pro Phe
                85                  90                  95      
Ala Ala Val Ala Ala Ala Asn Cys Ile Asn Ile Pro Leu Met Arg Gln
            100                 105                 110         
Arg Glu Leu Lys Val Gly Ile Pro Val Thr Asp Glu Asn Gly Asn Arg
        115                 120                 125             
Leu Gly Glu Ser Ala Asn Ala Ala Lys Gln Ala Ile Thr Gln Val Val
    130                 135                 140                 
Val Ser Arg Ile Leu Met Ala Ala Pro Gly Met Ala Ile Pro Pro Phe
145                 150                 155                 160 
Ile Met Asn Thr Leu Glu Lys Lys Ala Phe Leu Lys Arg Phe Pro Trp
                165                 170                 175     
Met Ser Ala Pro Ile Gln Val Gly Leu Val Gly Phe Cys Leu Val Phe
            180                 185                 190         
Ala Thr Pro Leu Cys Cys Ala Leu Phe Pro Gln Lys Ser Ser Met Ser
        195                 200                 205             
Val Thr Ser Leu Glu Ala Glu Leu Gln Ala Lys Ile Gln Glu Ser His
    210                 215                 220                 
Pro Glu Leu Arg Arg Val Tyr Phe Asn Lys Gly Leu
225                 230                 235     


<210> 1321
<211> 570
<212> PRT
<213> Homo sapiens

<400> 1321
Met Gly His Phe Thr Lys Pro Gln Gln Leu Gln Glu Glu Met Lys Glu
 1               5                  10                  15      
Leu Gln Gln Ser Thr Glu Lys Ala Val Ala Ala Arg Asp Lys Leu Met
            20                  25                  30          
Asp Arg His Gln Asp Ile Ser Lys Ala Phe Thr Lys Thr Asp Gln Ser
        35                  40                  45              
Lys Thr Asn Tyr Ile Ser Ile Cys Lys Met His Glu Val Leu Glu Glu
    50                  55                  60                  
Cys Gly Cys Ser Leu Thr Glu Gly Glu Leu Thr His Leu Leu Asn Ser
65                  70                  75                  80  
Trp Gly Val Ser Arg His Asp Asn Ala Ile Asn Tyr Leu Asp Phe Leu
                85                  90                  95      
Arg Ala Val Glu Asn Ser Lys Ser Thr Gly Ala Gln Pro Lys Glu Lys
            100                 105                 110         
Glu Glu Ser Met Pro Ile Asn Phe Ala Thr Leu Asn Pro Gln Glu Val
        115                 120                 125             
Val Arg Lys Ile Gln Glu Val Val Glu Ser Ser Gln Leu Ala Leu Ser
    130                 135                 140                 
Thr Ala Phe Ser Ala Leu Asp Lys Glu Asp Thr Gly Phe Val Lys Ala
145                 150                 155                 160 
Thr Glu Phe Gly Gln Val Leu Lys Asp Phe Cys Tyr Lys Leu Thr Asp
                165                 170                 175     
Asn Gln Tyr His Tyr Phe Leu Arg Lys Leu Arg Ile His Leu Thr Pro
            180                 185                 190         
Tyr Ile Asn Trp Lys Tyr Phe Leu Gln Asn Phe Ser Cys Phe Leu Glu
        195                 200                 205             
Glu Thr Ala Asp Glu Trp Ala Glu Lys Met Pro Lys Gly Pro Pro Pro
    210                 215                 220                 
Thr Ser Pro Lys Ala Thr Ala Asp Arg Asp Ile Leu Ala Arg Leu His
225                 230                 235                 240 
Lys Ala Val Thr Ser His Tyr His Ala Ile Thr Gln Glu Phe Glu Asn
                245                 250                 255     
Phe Asp Thr Met Lys Thr Asn Thr Ile Ser Arg Glu Glu Phe Arg Ala
            260                 265                 270         
Ile Cys Asn Arg Arg Val Gln Ile Leu Thr Asp Glu Gln Phe Asp Arg
        275                 280                 285             
Leu Trp Asn Glu Met Pro Val Asn Ala Lys Gly Arg Leu Lys Tyr Pro
    290                 295                 300                 
Asp Phe Leu Ser Arg Phe Ser Ser Glu Thr Ala Ala Thr Pro Met Ala
305                 310                 315                 320 
Thr Gly Asp Ser Ala Val Ala Gln Arg Gly Ser Ser Val Pro Asp Val
                325                 330                 335     
Ser Glu Gly Thr Arg Ser Ala Leu Ser Leu Pro Thr Gln Glu Leu Arg
            340                 345                 350         
Pro Gly Ser Lys Ser Gln Ser His Pro Cys Thr Pro Ala Ser Thr Thr
        355                 360                 365             
Val Ile Pro Gly Thr Pro Pro Leu Gln Asn Cys Asp Pro Ile Glu Ser
    370                 375                 380                 
Arg Leu Arg Lys Arg Ile Gln Gly Cys Trp Arg Gln Leu Leu Lys Glu
385                 390                 395                 400 
Cys Lys Glu Lys Asp Val Ala Arg Gln Gly Asp Ile Asn Ala Ser Asp
                405                 410                 415     
Phe Leu Ala Leu Val Glu Lys Phe Asn Leu Asp Ile Ser Lys Glu Glu
            420                 425                 430         
Cys Gln Gln Leu Ile Ile Lys Tyr Asp Leu Lys Ser Asn Gly Lys Phe
        435                 440                 445             
Ala Tyr Cys Asp Phe Ile Gln Ser Cys Val Leu Leu Leu Lys Ala Lys
    450                 455                 460                 
Glu Ser Ser Leu Met His Arg Met Lys Ile Gln Asn Ala His Lys Met
465                 470                 475                 480 
Lys Glu Ala Gly Ala Glu Thr Pro Ser Phe Tyr Ser Ala Leu Leu Arg
                485                 490                 495     
Ile Gln Pro Lys Ile Val His Cys Trp Arg Pro Met Arg Arg Thr Phe
            500                 505                 510         
Lys Ser Tyr Asp Glu Ala Gly Thr Gly Leu Leu Ser Val Ala Asp Phe
        515                 520                 525             
Arg Thr Val Leu Arg Gln Tyr Ser Ile Asn Leu Ser Glu Glu Glu Phe
    530                 535                 540                 
Phe His Ile Leu Glu Tyr Tyr Asp Lys Thr Leu Ser Ser Lys Ile Ser
545                 550                 555                 560 
Tyr Asn Asp Phe Leu Arg Ala Phe Leu Gln
                565                 570 


<210> 1322
<211> 191
<212> PRT
<213> Homo sapiens

<400> 1322
Met Lys Arg Met Ala Glu Asn Glu Leu Ser Arg Ser Val Asn Glu Phe
 1               5                  10                  15      
Leu Ser Lys Leu Gln Asp Asp Leu Lys Glu Ala Met Asn Thr Met Met
            20                  25                  30          
Cys Ser Arg Cys Gln Gly Lys His Arg Arg Phe Glu Met Asp Arg Glu
        35                  40                  45              
Pro Lys Ser Ala Arg Tyr Cys Ala Glu Cys Asn Arg Leu His Pro Ala
    50                  55                  60                  
Glu Glu Gly Asp Phe Trp Ala Glu Ser Ser Met Leu Gly Leu Lys Ile
65                  70                  75                  80  
Thr Tyr Phe Ala Leu Met Asp Gly Lys Val Tyr Asp Ile Thr Glu Trp
                85                  90                  95      
Ala Gly Cys Gln Arg Val Gly Ile Ser Pro Asp Thr His Arg Val Pro
            100                 105                 110         
Tyr His Ile Ser Phe Gly Ser Arg Ile Pro Gly Thr Arg Gly Arg Gln
        115                 120                 125             
Arg Ala Thr Pro Asp Ala Pro Pro Ala Asp Leu Gln Asp Phe Leu Ser
    130                 135                 140                 
Arg Ile Phe Gln Val Pro Pro Gly Gln Met Pro Met Gly Thr Ser Leu
145                 150                 155                 160 
Gln Leu Leu Ser Leu Pro Leu Glu Pro Leu Gln Pro Leu Ser Pro Thr
                165                 170                 175     
Ala Gln Tyr Pro Arg Glu Lys Pro Asn Leu Ser Gly Gly Arg Lys
            180                 185                 190     


<210> 1323
<211> 131
<212> PRT
<213> Homo sapiens

<400> 1323
Met Glu Ala Gln Ala Gln Gly Leu Leu Glu Thr Glu Pro Leu Gln Gly
 1               5                  10                  15      
Thr Asp Glu Asp Ala Val Ala Ser Ala Asp Phe Ser Ser Met Leu Ser
            20                  25                  30          
Glu Glu Glu Lys Glu Glu Leu Lys Ala Glu Leu Val Gln Leu Glu Asp
        35                  40                  45              
Glu Ile Thr Thr Leu Arg Gln Val Leu Ser Ala Lys Glu Arg His Leu
    50                  55                  60                  
Val Glu Ile Lys Gln Lys Leu Gly Met Asn Leu Met Asn Glu Leu Lys
65                  70                  75                  80  
Gln Asn Phe Ser Lys Ser Trp His Asp Met Gln Thr Thr Thr Ala Tyr
                85                  90                  95      
Lys Lys Thr His Glu Thr Leu Ser His Ala Gly Gln Lys Ala Thr Ala
            100                 105                 110         
Ala Phe Ser Asn Val Gly Thr Ala Ile Ser Lys Lys Phe Gly Asp Met
        115                 120                 125             
Arg Arg Lys
    130     


<210> 1324
<211> 737
<212> PRT
<213> Homo sapiens

<400> 1324
Met Arg Gly Pro Pro Ala Trp Pro Leu Arg Leu Leu Glu Pro Pro Ser
 1               5                  10                  15      
Pro Ala Glu Pro Gly Arg Leu Leu Pro Val Ala Cys Val Trp Ala Ala
            20                  25                  30          
Ala Ser Arg Val Pro Gly Ser Leu Ser Pro Phe Thr Gly Leu Arg Pro
        35                  40                  45              
Ala Arg Leu Trp Gly Ala Gly Pro Ala Leu Leu Trp Gly Val Gly Ala
    50                  55                  60                  
Ala Arg Arg Trp Arg Ser Gly Cys Arg Gly Gly Gly Pro Gly Ala Ser
65                  70                  75                  80  
Arg Gly Val Leu Gly Leu Ala Arg Leu Leu Gly Leu Trp Ala Arg Gly
                85                  90                  95      
Pro Gly Ser Cys Arg Cys Gly Ala Phe Ala Gly Pro Gly Ala Pro Arg
            100                 105                 110         
Leu Pro Arg Ala Arg Phe Pro Gly Gly Pro Ala Ala Ala Ala Trp Ala
        115                 120                 125             
Gly Asp Glu Ala Trp Arg Arg Gly Pro Ala Ala Pro Pro Gly Asp Lys
    130                 135                 140                 
Gly Arg Leu Arg Pro Ala Ala Ala Gly Leu Pro Glu Ala Arg Lys Leu
145                 150                 155                 160 
Leu Gly Leu Ala Tyr Pro Glu Arg Arg Arg Leu Ala Ala Ala Val Gly
                165                 170                 175     
Phe Leu Thr Met Ser Ser Val Ile Ser Met Ser Ala Pro Phe Phe Leu
            180                 185                 190         
Gly Lys Ile Ile Asp Val Ile Tyr Thr Asn Pro Thr Val Asp Tyr Ser
        195                 200                 205             
Asp Asn Leu Thr Arg Leu Cys Leu Gly Leu Ser Ala Val Phe Leu Cys
    210                 215                 220                 
Gly Ala Ala Ala Asn Ala Ile Arg Val Tyr Leu Met Gln Thr Ser Gly
225                 230                 235                 240 
Gln Arg Ile Val Asn Arg Leu Arg Thr Ser Leu Phe Ser Ser Ile Leu
                245                 250                 255     
Arg Gln Glu Val Ala Phe Phe Asp Lys Thr Arg Thr Gly Glu Leu Ile
            260                 265                 270         
Asn Arg Leu Ser Ser Asp Thr Ala Leu Leu Gly Arg Ser Val Thr Glu
        275                 280                 285             
Asn Leu Ser Asp Gly Leu Arg Ala Gly Ala Gln Ala Ser Val Gly Ile
    290                 295                 300                 
Ser Met Met Phe Phe Val Ser Pro Asn Leu Ala Thr Phe Val Leu Ser
305                 310                 315                 320 
Val Val Pro Pro Val Ser Ile Ile Ala Val Ile Tyr Gly Arg Tyr Leu
                325                 330                 335     
Arg Lys Leu Thr Lys Val Thr Gln Asp Ser Leu Ala Gln Ala Thr Gln
            340                 345                 350         
Leu Ala Glu Glu Arg Ile Gly Asn Val Arg Thr Val Arg Ala Phe Gly
        355                 360                 365             
Lys Glu Met Thr Glu Ile Glu Lys Tyr Ala Ser Lys Val Asp His Val
    370                 375                 380                 
Met Gln Leu Ala Arg Lys Glu Ala Phe Ala Arg Ala Gly Phe Phe Gly
385                 390                 395                 400 
Ala Thr Gly Leu Ser Gly Asn Leu Ile Val Leu Ser Val Leu Tyr Lys
                405                 410                 415     
Gly Gly Leu Leu Met Gly Ser Ala His Met Thr Val Gly Glu Leu Ser
            420                 425                 430         
Ser Phe Leu Met Tyr Ala Phe Trp Val Gly Ile Ser Ile Gly Gly Leu
        435                 440                 445             
Ser Ser Phe Tyr Ser Glu Leu Met Lys Gly Leu Gly Ala Gly Gly Arg
    450                 455                 460                 
Leu Trp Glu Leu Leu Glu Arg Glu Pro Lys Leu Pro Phe Asn Glu Gly
465                 470                 475                 480 
Val Ile Leu Asn Glu Lys Ser Phe Gln Gly Ala Leu Glu Phe Lys Asn
                485                 490                 495     
Val His Phe Ala Tyr Pro Ala Arg Pro Glu Val Pro Ile Phe Gln Asp
            500                 505                 510         
Phe Ser Leu Ser Ile Pro Ser Gly Ser Val Thr Ala Leu Val Gly Pro
        515                 520                 525             
Ser Gly Ser Gly Lys Ser Thr Val Leu Ser Leu Leu Leu Arg Leu Tyr
    530                 535                 540                 
Asp Pro Ala Ser Gly Thr Ile Ser Leu Asp Gly His Asp Ile Arg Gln
545                 550                 555                 560 
Leu Asn Pro Val Trp Leu Arg Ser Lys Ile Gly Thr Val Ser Gln Glu
                565                 570                 575     
Pro Ile Leu Phe Ser Cys Ser Ile Ala Glu Asn Ile Ala Tyr Gly Ala
            580                 585                 590         
Asp Asp Pro Ser Ser Val Thr Ala Glu Glu Ile Gln Arg Gly Leu Lys
        595                 600                 605             
Gly Gln Ala Val Ala Phe Ile Arg Asn Phe Pro Gln Gly Phe Asn Thr
    610                 615                 620                 
Val Val Gly Glu Lys Gly Val Leu Leu Ser Gly Gly Gln Lys Gln Arg
625                 630                 635                 640 
Ile Ala Ile Ala Arg Ala Leu Leu Lys Asn Pro Lys Ile Leu Leu Leu
                645                 650                 655     
Asp Glu Ala Thr Ser Ala Leu Asp Ala Glu Asn Glu Tyr Leu Val Gln
            660                 665                 670         
Glu Ala Leu Asp Arg Leu Met Asp Gly Arg Thr Val Leu Val Ile Ala
        675                 680                 685             
His Arg Leu Ser Thr Ile Lys Asn Ala Asn Met Val Ala Val Leu Asp
    690                 695                 700                 
Gln Gly Lys Ile Thr Glu Tyr Gly Lys His Glu Glu Leu Leu Ser Lys
705                 710                 715                 720 
Pro Asn Gly Ile Tyr Arg Lys Leu Met Asn Lys Gln Ser Phe Ile Ser
                725                 730                 735     
Ala
    


<210> 1325
<211> 1042
<212> PRT
<213> Homo sapiens

<400> 1325
Ile Gln Ser Arg Leu Arg Lys Lys Arg Arg Glu Glu Gly Pro Ala Glu
 1               5                  10                  15      
Thr Val Gly Ser Glu Ala Ser Asp Thr Val Glu Gly Val Leu Pro Ser
            20                  25                  30          
Lys Gln Glu Pro Glu Asn Asp Gln Gly Val Val Ser Gln Ala Gly Lys
        35                  40                  45              
Asp Asp Arg Glu Ser Lys Leu Glu Gly Lys Ala Ala Gln Asp Ile Lys
    50                  55                  60                  
Asp Glu Glu Pro Gly Asp Leu Gly Arg Pro Lys Pro Glu Cys Glu Gly
65                  70                  75                  80  
Tyr Asp Pro Asn Ala Leu Tyr Cys Ile Cys Arg Gln Pro His Asn Asn
                85                  90                  95      
Arg Phe Met Ile Cys Cys Asp Arg Cys Glu Glu Trp Phe His Gly Asp
            100                 105                 110         
Cys Val Gly Ile Ser Glu Ala Arg Gly Arg Leu Leu Glu Arg Asn Gly
        115                 120                 125             
Glu Asp Tyr Ile Cys Pro Asn Cys Thr Ile Leu Gln Val Gln Asp Glu
    130                 135                 140                 
Thr His Ser Glu Thr Ala Asp Gln Gln Glu Ala Lys Trp Arg Pro Gly
145                 150                 155                 160 
Asp Ala Asp Gly Thr Asp Cys Thr Ser Ile Gly Thr Ile Glu Gln Lys
                165                 170                 175     
Ser Ser Glu Asp Gln Gly Ile Lys Gly Arg Ile Glu Lys Ala Ala Asn
            180                 185                 190         
Pro Ser Gly Lys Lys Lys Leu Lys Ile Phe Gln Pro Gly Pro Gly Pro
        195                 200                 205             
Val Pro Thr Gln Leu Pro Val Leu Trp Gln Val Leu Glu Ile Ala Val
    210                 215                 220                 
Ser Arg Ser Ile Ser Ala Phe Thr Leu Leu His Cys Ile Ser Cys Lys
225                 230                 235                 240 
Val Ile Glu Ala Pro Gly Ala Ser Lys Cys Ile Gly Pro Gly Cys Cys
                245                 250                 255     
His Val Ala Gln Pro Asp Ser Val Tyr Cys Ser Asn Asp Cys Ile Leu
            260                 265                 270         
Lys His Ala Ala Ala Thr Met Lys Phe Leu Ser Ser Gly Lys Glu Gln
        275                 280                 285             
Lys Pro Lys Pro Lys Glu Lys Met Lys Met Lys Pro Glu Lys Pro Ser
    290                 295                 300                 
Leu Pro Lys Cys Gly Ala Gln Ala Gly Ile Lys Ile Ser Ser Val His
305                 310                 315                 320 
Lys Arg Pro Ala Pro Glu Lys Lys Glu Thr Thr Val Lys Lys Ala Val
                325                 330                 335     
Val Val Pro Ala Arg Ser Glu Ala Leu Gly Lys Glu Ala Ala Cys Glu
            340                 345                 350         
Ser Ser Thr Pro Ser Trp Ala Ser Asp His Asn Tyr Asn Ala Val Lys
        355                 360                 365             
Pro Glu Lys Thr Ala Ala Pro Ser Pro Ser Leu Leu Tyr Lys Ser Thr
    370                 375                 380                 
Lys Glu Asp Arg Arg Ser Glu Glu Lys Ala Ala Ala Met Ala Ala Ser
385                 390                 395                 400 
Lys Lys Thr Ala Pro Pro Gly Ser Ala Val Gly Lys Gln Pro Ala Pro
                405                 410                 415     
Arg Asn Leu Val Pro Lys Lys Ser Ser Phe Ala Asn Val Ala Ala Ala
            420                 425                 430         
Thr Pro Ala Ile Lys Lys Pro Pro Ser Gly Phe Lys Gly Thr Ile Pro
        435                 440                 445             
Lys Arg Pro Trp Leu Ser Ala Thr Pro Ser Ser Gly Ala Ser Ala Ala
    450                 455                 460                 
Arg Gln Ala Gly Pro Ala Pro Ala Ala Ala Thr Ala Ala Ser Lys Lys
465                 470                 475                 480 
Phe Pro Gly Ser Ala Ala Leu Val Gly Ala Val Arg Lys Pro Val Val
                485                 490                 495     
Pro Ser Val Pro Met Ala Ser Pro Ala Pro Gly Arg Leu Gly Ala Met
            500                 505                 510         
Ser Ala Ala Pro Ser Gln Pro Asn Ser Gln Ile Arg Gln Asn Ile Arg
        515                 520                 525             
Arg Ser Leu Lys Glu Ile Leu Trp Lys Arg Val Asn Asp Ser Asp Asp
    530                 535                 540                 
Leu Ile Met Thr Glu Asn Glu Val Gly Lys Ile Ala Leu His Ile Glu
545                 550                 555                 560 
Lys Glu Met Phe Asn Leu Phe Gln Val Thr Asp Asn Arg Tyr Lys Ser
                565                 570                 575     
Lys Tyr Arg Ser Ile Met Phe Asn Leu Lys Asp Pro Lys Asn Gln Gly
            580                 585                 590         
Leu Phe His Arg Val Leu Arg Glu Glu Ile Ser Leu Ala Lys Leu Val
        595                 600                 605             
Arg Leu Lys Pro Glu Glu Leu Val Ser Lys Glu Leu Ser Thr Trp Lys
    610                 615                 620                 
Glu Arg Pro Ala Arg Ser Val Met Glu Ser Arg Thr Lys Leu His Asn
625                 630                 635                 640 
Glu Ser Lys Lys Thr Ala Pro Arg Gln Glu Ala Ile Pro Asp Leu Glu
                645                 650                 655     
Asp Ser Pro Pro Val Ser Asp Ser Glu Glu Gln Gln Glu Ser Ala Arg
            660                 665                 670         
Ala Val Pro Glu Lys Ser Thr Ala Pro Leu Leu Asp Val Phe Ser Ser
        675                 680                 685             
Met Leu Lys Asp Thr Thr Ser Gln His Arg Ala His Leu Phe Asp Leu
    690                 695                 700                 
Asn Cys Lys Ile Cys Thr Gly Gln Val Pro Ser Ala Glu Asp Glu Pro
705                 710                 715                 720 
Ala Pro Lys Lys Gln Lys Leu Ser Ala Ser Val Lys Lys Glu Asp Leu
                725                 730                 735     
Lys Ser Lys His Asp Ser Ser Ala Pro Asp Pro Ala Pro Asp Ser Ala
            740                 745                 750         
Asp Glu Val Met Pro Glu Ala Val Pro Glu Val Ala Ser Glu Pro Gly
        755                 760                 765             
Leu Glu Ser Ala Ser His Pro Asn Val Asp Arg Thr Tyr Phe Pro Gly
    770                 775                 780                 
Pro Pro Gly Asp Gly His Pro Glu Pro Ser Pro Leu Glu Asp Leu Ser
785                 790                 795                 800 
Pro Cys Pro Ala Ser Cys Gly Ser Gly Val Val Thr Thr Val Thr Val
                805                 810                 815     
Ser Gly Arg Asp Pro Arg Thr Ala Pro Ser Ser Ser Cys Thr Ala Val
            820                 825                 830         
Ala Ser Ala Ala Ser Arg Pro Asp Ser Thr His Met Val Glu Ala Arg
        835                 840                 845             
Gln Asp Val Pro Lys Pro Val Leu Thr Ser Val Met Val Pro Lys Ser
    850                 855                 860                 
Ile Leu Ala Lys Pro Ser Ser Ser Pro Asp Pro Arg Tyr Leu Ser Val
865                 870                 875                 880 
Pro Pro Ser Pro Asn Ile Ser Thr Ser Glu Ser Arg Ser Pro Pro Glu
                885                 890                 895     
Gly Asp Thr Thr Leu Phe Leu Ser Arg Leu Ser Thr Ile Trp Lys Gly
            900                 905                 910         
Phe Ile Asn Met Gln Ser Val Ala Lys Phe Val Thr Lys Ala Tyr Pro
        915                 920                 925             
Val Ser Gly Cys Phe Asp Tyr Leu Ser Glu Asp Leu Pro Asp Thr Ile
    930                 935                 940                 
His Ile Gly Gly Arg Ile Ala Pro Lys Thr Val Trp Asp Tyr Val Gly
945                 950                 955                 960 
Lys Leu Lys Ser Ser Val Ser Lys Glu Leu Cys Leu Ile Arg Phe His
                965                 970                 975     
Pro Ala Thr Glu Glu Glu Glu Val Ala Tyr Ile Ser Leu Tyr Ser Tyr
            980                 985                 990         
Phe Ser Ser Arg Gly Arg Phe Gly Val Val Ala Asn Asn Asn Arg His
        995                 1000                1005            
Val Lys Asp Leu Tyr Leu Ile Pro Leu Ser Ala Gln Asp Pro Val Pro
    1010                1015                1020                
Ser Lys Leu Leu Pro Phe Glu Gly Pro Gly Lys Arg Arg Leu Ser Gly
1025                1030                1035                1040
Trp Arg
        


<210> 1326
<211> 1957
<212> PRT
<213> Homo sapiens

<400> 1326
Val Gly Leu Asp Asp Ile Met Asp Glu Gly Val Val Lys Glu Ser Gly
 1               5                  10                  15      
Asn Asp Thr Ile Asp Glu Glu Glu Leu Ile Leu Pro Asn Arg Asn Leu
            20                  25                  30          
Arg Asp Lys Val Glu Glu Asn Ser Val Arg Ser Pro Arg Lys Ser Pro
        35                  40                  45              
Arg Leu Met Ala Gln Glu Gln Val Arg Ser Leu Arg Gln Ser Thr Ile
    50                  55                  60                  
Ala Lys Arg Ser Asn Ala Ala Pro Leu Ser Asn Thr Lys Lys Ala Ser
65                  70                  75                  80  
Gly Lys Thr Val Ser Thr Ala Lys Ala Gly Val Lys Gln Pro Glu Arg
                85                  90                  95      
Ser Gln Val Lys Glu Glu Val Cys Met Ser Leu Lys Pro Glu Tyr His
            100                 105                 110         
Lys Glu Asn Arg Arg Cys Ser Arg Asn Ser Gly Gln Ile Glu Val Val
        115                 120                 125             
Pro Glu Val Ser Val Ser Ser Ser His Ser Ser Val Ser Ser Cys Leu
    130                 135                 140                 
Glu Met Lys Asp Glu Asp Gly Leu Asp Ser Lys His Lys Cys Asn Asn
145                 150                 155                 160 
Pro Gly Glu Ile Asp Val Pro Ser His Glu Leu Asn Cys Ser Leu Leu
                165                 170                 175     
Ser Glu Thr Cys Val Thr Ile Gly Glu Lys Lys Asn Glu Ala Leu Met
            180                 185                 190         
Glu Cys Lys Ala Lys Pro Val Gly Ser Pro Leu Phe Lys Phe Ser Asp
        195                 200                 205             
Lys Glu Glu His Glu Gln Asn Asp Ser Ile Ser Gly Lys Thr Gly Glu
    210                 215                 220                 
Thr Val Val Glu Glu Met Ile Ala Thr Arg Lys Val Glu Gln Asp Ser
225                 230                 235                 240 
Lys Glu Thr Val Lys Leu Ser His Glu Asp Asp His Ile Leu Glu Asp
                245                 250                 255     
Ala Gly Ser Ser Asp Ile Ser Ser Asp Ala Ala Cys Thr Asn Pro Asn
            260                 265                 270         
Lys Thr Glu Asn Ser Leu Val Gly Leu Pro Ser Cys Val Asp Glu Val
        275                 280                 285             
Thr Glu Cys Asn Leu Glu Leu Lys Asp Thr Met Gly Ile Ala Asp Lys
    290                 295                 300                 
Thr Glu Asn Thr Leu Glu Arg Asn Lys Ile Glu Pro Leu Gly Tyr Cys
305                 310                 315                 320 
Glu Asp Ala Glu Ser Asn Arg Gln Leu Glu Ser Thr Glu Phe Asn Lys
                325                 330                 335     
Ser Asn Leu Glu Val Val Asp Thr Ser Thr Phe Gly Pro Glu Ser Asn
            340                 345                 350         
Ile Leu Glu Asn Ala Ile Cys Asp Val Pro Asp Gln Asn Ser Lys Gln
        355                 360                 365             
Leu Asn Ala Ile Glu Ser Thr Lys Ile Glu Ser His Glu Thr Ala Asn
    370                 375                 380                 
Leu Gln Asp Asp Arg Asn Ser Gln Ser Ser Ser Val Ser Tyr Leu Glu
385                 390                 395                 400 
Ser Lys Ser Val Lys Ser Lys His Thr Lys Pro Val Ile His Ser Lys
                405                 410                 415     
Gln Asn Met Thr Thr Asp Ala Pro Lys Lys Ile Val Ala Ala Lys Tyr
            420                 425                 430         
Glu Val Ile His Ser Lys Thr Lys Val Asn Val Lys Ser Val Lys Arg
        435                 440                 445             
Asn Thr Asp Val Pro Glu Ser Gln Gln Asn Phe His Arg Pro Val Lys
    450                 455                 460                 
Val Arg Lys Lys Gln Ile Asp Lys Glu Pro Lys Ile Gln Ser Cys Asn
465                 470                 475                 480 
Ser Gly Val Lys Ser Val Lys Asn Gln Ala His Ser Val Leu Lys Lys
                485                 490                 495     
Thr Leu Gln Asp Gln Thr Leu Val Gln Ile Phe Lys Pro Leu Thr His
            500                 505                 510         
Ser Leu Ser Asp Lys Ser His Ala His Pro Gly Cys Leu Lys Glu Pro
        515                 520                 525             
His His Pro Ala Gln Thr Gly His Val Ser His Ser Ser Gln Lys Gln
    530                 535                 540                 
Cys His Lys Pro Gln Gln Gln Ala Pro Ala Met Lys Thr Asn Ser His
545                 550                 555                 560 
Val Lys Glu Glu Leu Glu His Pro Gly Val Glu His Phe Lys Glu Glu
                565                 570                 575     
Asp Lys Leu Lys Leu Lys Lys Pro Glu Lys Asn Leu Gln Pro Arg Gln
            580                 585                 590         
Arg Arg Ser Ser Lys Ser Phe Ser Leu Asp Glu Pro Pro Leu Phe Ile
        595                 600                 605             
Pro Asp Asn Ile Ala Thr Ile Arg Arg Glu Gly Ser Asp His Ser Ser
    610                 615                 620                 
Ser Phe Glu Ser Lys Tyr Met Trp Thr Pro Ser Lys Gln Cys Gly Phe
625                 630                 635                 640 
Cys Lys Lys Pro His Gly Asn Arg Phe Met Val Gly Cys Gly Arg Cys
                645                 650                 655     
Asp Asp Trp Phe His Gly Asp Cys Val Gly Leu Ser Leu Ser Gln Ala
            660                 665                 670         
Gln Gln Met Gly Glu Glu Asp Lys Glu Tyr Val Cys Val Lys Cys Cys
        675                 680                 685             
Ala Glu Glu Asp Lys Lys Thr Glu Ile Leu Asp Pro Asp Thr Leu Glu
    690                 695                 700                 
Asn Gln Ala Thr Val Glu Phe His Ser Gly Asp Lys Thr Met Glu Cys
705                 710                 715                 720 
Glu Lys Leu Gly Leu Ser Lys His Thr Thr Asn Asp Arg Thr Lys Tyr
                725                 730                 735     
Ile Asp Asp Thr Val Lys His Lys Val Lys Ile Leu Lys Arg Glu Ser
            740                 745                 750         
Gly Glu Gly Arg Asn Ser Ser Asp Cys Arg Asp Asn Glu Ile Lys Lys
        755                 760                 765             
Trp Gln Leu Ala Pro Leu Arg Lys Met Gly Gln Pro Val Leu Pro Arg
    770                 775                 780                 
Arg Ser Ser Glu Glu Lys Ser Glu Lys Ile Pro Lys Glu Ser Thr Thr
785                 790                 795                 800 
Val Thr Cys Thr Gly Glu Lys Ala Ser Lys Pro Gly Thr His Glu Lys
                805                 810                 815     
Gln Glu Met Lys Lys Lys Lys Val Glu Lys Gly Val Leu Asn Val His
            820                 825                 830         
Pro Ala Ala Ser Ala Ser Lys Pro Ser Ala Asp Gln Ile Arg Gln Ser
        835                 840                 845             
Val Arg His Ser Leu Lys Asp Ile Leu Met Lys Arg Leu Thr Asp Ser
    850                 855                 860                 
Asn Leu Lys Val Pro Glu Glu Lys Ala Ala Lys Val Ala Thr Lys Ile
865                 870                 875                 880 
Glu Lys Glu Leu Phe Ser Phe Phe Arg Asp Thr Asp Ala Lys Tyr Lys
                885                 890                 895     
Asn Lys Tyr Arg Ser Leu Met Phe Asn Leu Lys Asp Pro Lys Asn Asn
            900                 905                 910         
Ile Leu Phe Lys Lys Val Leu Lys Gly Glu Val Thr Pro Asp His Leu
        915                 920                 925             
Ile Arg Met Ser Pro Glu Glu Leu Ala Ser Lys Glu Leu Ala Ala Trp
    930                 935                 940                 
Arg Arg Arg Glu Asn Arg His Thr Ile Glu Met Ile Glu Lys Glu Gln
945                 950                 955                 960 
Arg Glu Val Glu Arg Arg Pro Ile Thr Lys Ile Thr His Lys Gly Glu
                965                 970                 975     
Ile Glu Ile Glu Ser Asp Ala Pro Met Lys Glu Gln Glu Ala Ala Met
            980                 985                 990         
Glu Ile Gln Glu Pro Ala Ala Asn Lys Ser Leu Glu Lys Pro Glu Gly
        995                 1000                1005            
Ser Glu Lys Gln Lys Glu Glu Val Asp Ser Met Ser Lys Asp Thr Thr
    1010                1015                1020                
Ser Gln His Arg Gln His Leu Phe Asp Leu Asn Cys Lys Ile Cys Ile
1025                1030                1035                1040
Gly Arg Met Ala Pro Pro Val Asp Asp Leu Ser Pro Lys Lys Val Lys
                1045                1050                1055    
Val Val Val Gly Val Ala Arg Lys His Ser Asp Asn Glu Ala Glu Ser
            1060                1065                1070        
Ile Ala Asp Ala Leu Ser Ser Thr Ser Asn Ile Leu Ala Ser Glu Phe
        1075                1080                1085            
Phe Glu Glu Glu Lys Gln Glu Ser Pro Lys Ser Thr Phe Ser Pro Ala
    1090                1095                1100                
Pro Arg Pro Glu Met Pro Gly Thr Val Glu Val Glu Ser Thr Phe Leu
1105                1110                1115                1120
Ala Arg Leu Asn Phe Ile Trp Lys Gly Phe Ile Asn Met Pro Ser Val
                1125                1130                1135    
Ala Lys Phe Val Thr Lys Ala Tyr Pro Val Ser Gly Ser Pro Glu Tyr
            1140                1145                1150        
Leu Thr Glu Asp Leu Pro Asp Ser Ile Gln Val Gly Gly Arg Ile Ser
        1155                1160                1165            
Pro Gln Thr Val Trp Asp Tyr Val Glu Lys Ile Lys Ala Ser Gly Thr
    1170                1175                1180                
Lys Glu Ile Cys Val Val Arg Phe Thr Pro Val Thr Glu Glu Asp Gln
1185                1190                1195                1200
Ile Ser Tyr Thr Leu Leu Phe Ala Tyr Phe Ser Ser Arg Lys Arg Tyr
                1205                1210                1215    
Gly Val Ala Ala Asn Asn Met Lys Gln Val Lys Asp Met Tyr Leu Ile
            1220                1225                1230        
Pro Leu Gly Ala Thr Asp Lys Ile Pro His Pro Leu Val Pro Phe Asp
        1235                1240                1245            
Gly Pro Gly Leu Glu Leu His Arg Pro Asn Leu Leu Leu Gly Leu Ile
    1250                1255                1260                
Ile Arg Gln Lys Leu Lys Arg Gln His Ser Ala Cys Ala Ser Thr Ser
1265                1270                1275                1280
His Ile Ala Glu Thr Pro Glu Ser Ala Pro Pro Ile Ala Leu Pro Pro
                1285                1290                1295    
Asp Lys Lys Ser Lys Ile Glu Val Ser Thr Glu Glu Ala Pro Glu Glu
            1300                1305                1310        
Glu Asn Asp Phe Phe Asn Ser Phe Thr Thr Val Leu His Lys Gln Arg
        1315                1320                1325            
Asn Lys Pro Gln Gln Asn Leu Gln Glu Asp Leu Pro Thr Ala Val Glu
    1330                1335                1340                
Pro Leu Met Glu Val Thr Lys Gln Glu Pro Pro Lys Pro Leu Arg Phe
1345                1350                1355                1360
Leu Pro Gly Val Leu Ile Gly Trp Glu Asn Gln Pro Thr Thr Leu Glu
                1365                1370                1375    
Leu Ala Asn Lys Pro Leu Pro Val Asp Asp Ile Leu Gln Ser Leu Leu
            1380                1385                1390        
Gly Thr Thr Gly Gln Val Tyr Asp Gln Ala Gln Ser Val Met Glu Gln
        1395                1400                1405            
Asn Thr Val Lys Glu Ile Pro Phe Leu Asn Glu Gln Thr Asn Ser Lys
    1410                1415                1420                
Ile Glu Lys Thr Asp Asn Val Glu Val Thr Asp Gly Glu Asn Lys Glu
1425                1430                1435                1440
Ile Lys Val Lys Val Asp Asn Ile Ser Glu Ser Thr Asp Lys Ser Ala
                1445                1450                1455    
Glu Ile Glu Thr Ser Val Val Gly Ser Ser Ser Ile Ser Ala Gly Ser
            1460                1465                1470        
Leu Thr Ser Leu Ser Leu Arg Gly Lys Pro Pro Asp Val Ser Thr Glu
        1475                1480                1485            
Ala Phe Leu Thr Asn Leu Ser Ile Gln Ser Lys Gln Glu Glu Thr Val
    1490                1495                1500                
Glu Ser Lys Glu Lys Thr Leu Lys Arg Gln Leu Gln Glu Asp Gln Glu
1505                1510                1515                1520
Asn Asn Leu Gln Asp Asn Gln Thr Ser Asn Ser Ser Pro Cys Arg Ser
                1525                1530                1535    
Asn Val Gly Lys Gly Asn Ile Asp Gly Asn Val Ser Cys Ser Glu Asn
            1540                1545                1550        
Leu Val Ala Asn Thr Ala Arg Ser Pro Gln Phe Ile Asn Leu Lys Arg
        1555                1560                1565            
Asp Pro Arg Gln Ala Ala Gly Arg Ser Gln Pro Val Thr Thr Ser Glu
    1570                1575                1580                
Ser Lys Asp Gly Asp Ser Cys Arg Asn Gly Glu Lys His Met Leu Pro
1585                1590                1595                1600
Gly Leu Ser His Asn Lys Glu His Leu Thr Glu Gln Ile Asn Val Glu
                1605                1610                1615    
Glu Lys Leu Cys Ser Ala Glu Lys Asn Ser Cys Val Gln Gln Ser Asp
            1620                1625                1630        
Asn Leu Lys Val Ala Gln Asn Ser Pro Ser Val Glu Asn Ile Gln Thr
        1635                1640                1645            
Ser Gln Ala Glu Gln Ala Lys Pro Leu Gln Glu Asp Ile Leu Met Gln
    1650                1655                1660                
Asn Ile Glu Thr Val His Pro Phe Arg Arg Gly Ser Ala Val Ala Thr
1665                1670                1675                1680
Ser His Phe Glu Val Gly Asn Thr Cys Pro Ser Glu Phe Pro Ser Lys
                1685                1690                1695    
Ser Ile Thr Phe Thr Ser Arg Ser Thr Ser Pro Arg Thr Ser Thr Asn
            1700                1705                1710        
Phe Ser Pro Met Arg Pro Gln Gln Pro Asn Leu Gln His Leu Lys Ser
        1715                1720                1725            
Ser Pro Pro Gly Phe Pro Phe Pro Gly Pro Pro Asn Phe Pro Pro Gln
    1730                1735                1740                
Ser Met Phe Gly Phe Pro Pro His Leu Pro Pro Pro Leu Leu Pro Pro
1745                1750                1755                1760
Pro Gly Phe Gly Phe Ala Gln Asn Pro Met Val Pro Trp Pro Pro Val
                1765                1770                1775    
Val His Leu Pro Gly Gln Pro Gln Arg Met Met Gly Pro Leu Ser Gln
            1780                1785                1790        
Ala Ser Arg Tyr Ile Gly Pro Gln Asn Phe Tyr Gln Val Lys Asp Ile
        1795                1800                1805            
Arg Arg Pro Glu Arg Arg His Ser Asp Pro Trp Gly Arg Gln Asp Gln
    1810                1815                1820                
Gln Gln Leu Asp Arg Pro Phe Asn Arg Gly Lys Gly Asp Arg Gln Arg
1825                1830                1835                1840
Phe Tyr Ser Asp Ser His His Leu Lys Arg Glu Arg His Glu Lys Glu
                1845                1850                1855    
Trp Glu Gln Glu Ser Glu Arg His Arg Arg Arg Asp Arg Ser Gln Asp
            1860                1865                1870        
Lys Asp Arg Asp Arg Lys Ser Arg Glu Glu Gly His Lys Asp Lys Glu
        1875                1880                1885            
Arg Ala Arg Leu Ser His Gly Asp Arg Gly Thr Asp Gly Lys Ala Ser
    1890                1895                1900                
Arg Asp Ser Arg Asn Val Asp Lys Lys Pro Asp Lys Pro Lys Ser Glu
1905                1910                1915                1920
Asp Tyr Glu Lys Asp Lys Glu Arg Glu Lys Ser Lys His Arg Glu Gly
                1925                1930                1935    
Glu Lys Asp Arg Asp Arg Tyr His Lys Asp Arg Asp His Thr Asp Arg
            1940                1945                1950        
Thr Lys Ser Lys Arg
        1955        


<210> 1327
<211> 178
<212> PRT
<213> Homo sapiens

<400> 1327
Met Ala Phe Ala Gly Leu Thr Ala Asp Ala Arg Ile Val Ile Asn Arg
 1               5                  10                  15      
Ala Arg Val Glu Cys Gln Ser His Arg Leu Thr Val Glu Asp Pro Val
            20                  25                  30          
Thr Val Glu Tyr Ile Thr Arg Tyr Ile Ala Ser Leu Lys Gln Arg Tyr
        35                  40                  45              
Thr Gln Ser Asn Gly Arg Arg Pro Phe Gly Ile Ser Ala Leu Ile Val
    50                  55                  60                  
Gly Phe Asp Phe Asp Gly Thr Pro Arg Leu Tyr Gln Thr Asp Pro Ser
65                  70                  75                  80  
Gly Thr Tyr His Ala Trp Lys Ala Asn Ala Ile Gly Arg Gly Ala Lys
                85                  90                  95      
Ser Val Arg Glu Phe Leu Glu Lys Asn Tyr Thr Asp Glu Ala Ile Glu
            100                 105                 110         
Thr Asp Asp Leu Thr Ile Lys Leu Val Ile Lys Ala Leu Leu Glu Val
        115                 120                 125             
Val Gln Ser Gly Gly Lys Asn Ile Glu Leu Ala Val Met Arg Arg Asp
    130                 135                 140                 
Gln Ser Leu Lys Ile Leu Asn Pro Glu Glu Ile Glu Lys Tyr Val Ala
145                 150                 155                 160 
Glu Ile Glu Lys Glu Lys Glu Glu Asn Glu Lys Lys Lys Gln Lys Lys
                165                 170                 175     
Ala Ser
        


<210> 1328
<211> 1454
<212> PRT
<213> Homo sapiens

<400> 1328
Ile Glu Asp Gly Gly Lys Ala Ala Leu Ser Gln Lys Met Arg Thr Gly
 1               5                  10                  15      
Asp Glu Leu Val Asn Ile Asn Gly Thr Pro Leu Tyr Gly Ser Arg Gln
            20                  25                  30          
Glu Ala Leu Ile Leu Ile Lys Gly Ser Phe Arg Ile Leu Lys Leu Ile
        35                  40                  45              
Val Arg Arg Arg Asn Ala Pro Val Ser Arg Pro His Ser Trp His Val
    50                  55                  60                  
Ala Lys Leu Leu Glu Gly Cys Pro Glu Ala Ala Thr Thr Met His Phe
65                  70                  75                  80  
Pro Ser Glu Ala Phe Ser Leu Ser Trp His Ser Gly Cys Asn Thr Ser
                85                  90                  95      
Asp Val Cys Val Gln Trp Cys Pro Leu Ser Arg His Cys Ser Thr Glu
            100                 105                 110         
Lys Ser Ser Ser Ile Gly Ser Met Glu Ser Leu Glu Gln Pro Gly Gln
        115                 120                 125             
Ala Thr Tyr Glu Ser His Leu Leu Pro Ile Asp Gln Asn Met Tyr Pro
    130                 135                 140                 
Asn Gln Arg Asp Ser Ala Tyr Ser Ser Phe Ser Ala Ser Ser Asn Ala
145                 150                 155                 160 
Ser Asp Cys Ala Leu Ser Leu Arg Pro Glu Glu Pro Ala Ser Thr Asp
                165                 170                 175     
Cys Ile Met Gln Gly Pro Gly Pro Thr Lys Ala Pro Ser Gly Arg Pro
            180                 185                 190         
Asn Val Ala Glu Thr Ser Gly Gly Ser Arg Arg Thr Asn Gly Gly His
        195                 200                 205             
Leu Thr Pro Ser Ser Gln Met Ser Ser Arg Pro Gln Glu Gly Tyr Gln
    210                 215                 220                 
Ser Gly Pro Ala Lys Ala Val Arg Gly Pro Pro Gln Pro Pro Val Arg
225                 230                 235                 240 
Arg Asp Ser Leu Gln Ala Ser Arg Ala Gln Leu Leu Asn Gly Glu Gln
                245                 250                 255     
Arg Arg Ala Ser Glu Pro Val Val Pro Leu Pro Gln Lys Glu Lys Leu
            260                 265                 270         
Ser Leu Glu Pro Val Leu Pro Ala Arg Asn Pro Asn Arg Phe Cys Cys
        275                 280                 285             
Leu Ser Gly His Asp Gln Val Thr Ser Glu Gly His Gln Asn Cys Glu
    290                 295                 300                 
Phe Ser Gln Pro Pro Glu Ser Ser Gln Gln Gly Ser Glu His Leu Leu
305                 310                 315                 320 
Met Gln Ala Ser Thr Lys Ala Val Gly Ser Pro Lys Ala Cys Asp Arg
                325                 330                 335     
Ala Ser Ser Val Asp Ser Asn Pro Leu Asn Glu Ala Ser Ala Glu Leu
            340                 345                 350         
Ala Lys Ala Ser Phe Gly Arg Pro Pro His Leu Ile Gly Pro Thr Gly
        355                 360                 365             
His Arg His Ser Ala Pro Glu Gln Leu Leu Ala Ser His Leu Gln His
    370                 375                 380                 
Val His Leu Asp Thr Arg Gly Ser Lys Gly Met Glu Leu Pro Pro Val
385                 390                 395                 400 
Gln Asp Gly His Gln Trp Thr Leu Ser Pro Leu His Ser Ser His Lys
                405                 410                 415     
Gly Lys Lys Ser Pro Cys Pro Pro Thr Gly Gly Thr His Asp Gln Ser
            420                 425                 430         
Ser Lys Glu Arg Lys Thr Arg Gln Val Asp Asp Arg Ser Leu Val Leu
        435                 440                 445             
Gly His Gln Ser Gln Ser Ser Pro Pro His Gly Glu Ala Asp Gly His
    450                 455                 460                 
Pro Ser Glu Lys Gly Phe Leu Asp Pro Asn Arg Thr Ser Arg Ala Ala
465                 470                 475                 480 
Ser Glu Leu Ala Asn Gln Gln Pro Ser Ala Ser Gly Ser Leu Val Gln
                485                 490                 495     
Gln Ala Thr Asp Cys Ser Ser Thr Thr Lys Ala Ala Ser Gly Thr Glu
            500                 505                 510         
Ala Gly Glu Glu Gly Asp Ser Glu Pro Lys Glu Cys Ser Arg Met Gly
        515                 520                 525             
Gly Arg Arg Ser Gly Gly Thr Arg Gly Arg Ser Ile Gln Asn Arg Arg
    530                 535                 540                 
Lys Ser Glu Arg Phe Ala Thr Asn Leu Arg Asn Glu Ile Gln Arg Arg
545                 550                 555                 560 
Lys Ala Gln Leu Gln Lys Ser Lys Gly Pro Leu Ser Gln Leu Cys Asp
                565                 570                 575     
Thr Lys Glu Pro Val Glu Glu Thr Gln Glu Pro Pro Glu Ser Pro Pro
            580                 585                 590         
Leu Thr Ala Ser Asn Thr Ser Leu Leu Ser Ser Cys Lys Lys Pro Pro
        595                 600                 605             
Ser Pro Arg Asp Lys Leu Phe Asn Lys Ser Met Met Leu Arg Ala Arg
    610                 615                 620                 
Ser Ser Glu Cys Leu Ser Gln Ala Pro Glu Ser His Glu Ser Arg Thr
625                 630                 635                 640 
Gly Leu Glu Gly Arg Ile Ser Pro Gly Gln Arg Pro Gly Gln Ser Ser
                645                 650                 655     
Leu Gly Leu Asn Thr Trp Trp Lys Ala Pro Asp Pro Ser Ser Ser Asp
            660                 665                 670         
Pro Glu Lys Ala His Ala His Cys Gly Val Arg Gly Gly His Trp Arg
        675                 680                 685             
Trp Ser Pro Glu His Asn Ser Gln Pro Leu Val Ala Ala Ala Met Glu
    690                 695                 700                 
Gly Pro Ser Asn Pro Gly Asp Asn Lys Glu Leu Lys Ala Ser Thr Ala
705                 710                 715                 720 
Gln Ala Gly Glu Asp Ala Ile Leu Leu Pro Phe Ala Asp Arg Arg Lys
                725                 730                 735     
Phe Phe Glu Glu Ser Ser Lys Ser Leu Ser Thr Ser His Leu Pro Gly
            740                 745                 750         
Leu Thr Thr His Ser Asn Lys Thr Phe Thr Gln Arg Pro Lys Pro Ile
        755                 760                 765             
Asp Gln Asn Phe Gln Pro Met Ser Ser Ser Cys Arg Glu Leu Arg Arg
    770                 775                 780                 
His Pro Met Asp Gln Ser Tyr His Ser Ala Asp Gln Pro Tyr His Ala
785                 790                 795                 800 
Thr Asp Gln Ser Tyr His Ser Met Ser Pro Leu Gln Ser Glu Thr Pro
                805                 810                 815     
Thr Tyr Ser Glu Cys Phe Ala Ser Lys Gly Leu Glu Asn Ser Met Cys
            820                 825                 830         
Cys Lys Pro Leu His Cys Gly Asp Phe Asp Tyr His Arg Thr Cys Ser
        835                 840                 845             
Tyr Ser Cys Ser Val Gln Gly Ala Leu Val His Asp Pro Cys Ile Tyr
    850                 855                 860                 
Cys Ser Gly Glu Ile Cys Pro Ala Leu Leu Lys Arg Asn Met Met Pro
865                 870                 875                 880 
Asn Cys Tyr Asn Cys Arg Cys His His His Gln Cys Ile Arg Cys Ser
                885                 890                 895     
Val Cys Tyr His Asn Pro Gln His Ser Ala Leu Glu Asp Ser Ser Leu
            900                 905                 910         
Ala Pro Gly Asn Thr Trp Lys Pro Arg Lys Leu Thr Val Gln Glu Phe
        915                 920                 925             
Pro Gly Asp Lys Trp Asn Pro Ile Thr Gly Asn Arg Lys Thr Ser Gln
    930                 935                 940                 
Ser Gly Arg Glu Met Ala His Ser Lys Thr Ser Phe Ser Trp Ala Thr
945                 950                 955                 960 
Pro Phe His Pro Cys Leu Glu Asn Pro Ala Leu Asp Leu Ser Ser Tyr
                965                 970                 975     
Arg Ala Ile Ser Ser Leu Asp Leu Leu Gly Asp Phe Lys His Ala Leu
            980                 985                 990         
Lys Lys Ser Glu Glu Thr Ser Val Tyr Glu Glu Gly Ser Ser Leu Ala
        995                 1000                1005            
Ser Met Pro His Pro Leu Arg Ser Arg Ala Phe Ser Glu Ser His Ile
    1010                1015                1020                
Ser Leu Ala Pro Gln Ser Thr Arg Ala Trp Gly Gln His Arg Arg Glu
1025                1030                1035                1040
Leu Phe Ser Lys Gly Asp Glu Thr Gln Ser Asp Leu Leu Gly Ala Arg
                1045                1050                1055    
Lys Lys Ala Phe Pro Pro Pro Arg Pro Pro Pro Pro Asn Trp Glu Lys
            1060                1065                1070        
Tyr Arg Leu Phe Arg Ala Ala Gln Gln Gln Lys Gln Gln Gln Gln Gln
        1075                1080                1085            
Gln Lys Gln Gln Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
    1090                1095                1100                
Glu Glu Glu Glu Glu Glu Glu Glu Ala Glu Glu Glu Glu Glu Glu Leu
1105                1110                1115                1120
Pro Pro Gln Tyr Phe Ser Ser Glu Thr Ser Gly Ser Cys Ala Leu Asn
                1125                1130                1135    
Pro Glu Glu Val Leu Glu Gln Pro Gln Pro Leu Ser Phe Gly His Leu
            1140                1145                1150        
Glu Gly Ser Arg Gln Gly Ser Gln Ser Val Pro Ala Glu Gln Glu Ser
        1155                1160                1165            
Phe Ala Leu His Ser Ser Asp Phe Leu Pro Pro Ile Arg Gly His Leu
    1170                1175                1180                
Gly Ser Gln Pro Glu Gln Ala Gln Pro Pro Cys Tyr Tyr Gly Ile Gly
1185                1190                1195                1200
Gly Leu Trp Arg Thr Ser Gly Gln Glu Ala Thr Glu Ser Ala Lys Gln
                1205                1210                1215    
Glu Phe Gln His Phe Ser Pro Pro Ser Gly Ala Pro Gly Ile Pro Thr
            1220                1225                1230        
Ser Tyr Ser Ala Tyr Tyr Asn Ile Ser Val Ala Lys Ala Glu Leu Leu
        1235                1240                1245            
Asn Lys Leu Lys Asp Gln Pro Glu Met Ala Glu Ile Gly Leu Gly Glu
    1250                1255                1260                
Glu Glu Val Asp His Glu Leu Ala Gln Lys Lys Ile Gln Leu Ile Glu
1265                1270                1275                1280
Ser Ile Ser Arg Lys Leu Ser Val Leu Arg Glu Ala Gln Arg Gly Leu
                1285                1290                1295    
Leu Glu Asp Ile Asn Ala Asn Ser Ala Leu Gly Glu Glu Val Glu Ala
            1300                1305                1310        
Asn Leu Lys Ala Val Cys Lys Ser Asn Glu Phe Glu Lys Tyr His Leu
        1315                1320                1325            
Phe Val Gly Asp Leu Asp Lys Val Val Asn Leu Leu Leu Ser Leu Ser
    1330                1335                1340                
Gly Arg Leu Ala Arg Val Glu Asn Ala Leu Asn Ser Ile Asp Ser Glu
1345                1350                1355                1360
Ala Asn Gln Glu Lys Leu Val Leu Ile Glu Lys Lys Gln Gln Leu Thr
                1365                1370                1375    
Gly Gln Leu Ala Asp Ala Lys Glu Leu Lys Glu His Val Asp Arg Arg
            1380                1385                1390        
Glu Lys Leu Val Phe Gly Met Val Ser Arg Tyr Leu Pro Gln Asp Gln
        1395                1400                1405            
Leu Gln Asp Tyr Gln His Phe Val Lys Met Lys Ser Ala Leu Ile Ile
    1410                1415                1420                
Glu Gln Arg Glu Leu Glu Glu Lys Ile Lys Leu Gly Glu Glu Gln Leu
1425                1430                1435                1440
Lys Cys Leu Arg Glu Ser Leu Leu Leu Gly Pro Ser Asn Phe
                1445                1450                


<210> 1329
<211> 120
<212> PRT
<213> Homo sapiens

<400> 1329
Met Glu Arg Gln Leu Ile Met Gln Ser Glu Met Arg Glu Arg Gln Met
 1               5                  10                  15      
Ala Met Gln Ile Ala Trp Ser Arg Glu Phe Leu Lys Tyr Phe Gly Thr
            20                  25                  30          
Phe Phe Gly Leu Ala Ala Ile Ser Leu Thr Ala Gly Ala Ile Lys Lys
        35                  40                  45              
Lys Lys Pro Ala Phe Leu Val Pro Ile Val Pro Leu Ser Phe Ile Leu
    50                  55                  60                  
Thr Tyr Gln Tyr Asp Leu Gly Tyr Gly Thr Leu Leu Glu Arg Met Lys
65                  70                  75                  80  
Gly Glu Ala Glu Asp Ile Leu Glu Thr Glu Lys Ser Lys Leu Gln Leu
                85                  90                  95      
Pro Arg Gly Met Ile Thr Phe Glu Ser Ile Glu Lys Ala Arg Lys Glu
            100                 105                 110         
Gln Ser Arg Phe Phe Ile Asp Lys
        115                 120 


<210> 1330
<211> 371
<212> PRT
<213> Homo sapiens

<400> 1330
Glu Glu Asn Glu Asp Arg Leu Ile Asp Arg Ile Thr Leu Tyr Gln His
 1               5                  10                  15      
Leu Lys Ser Ser Leu Asn Glu Tyr Gln Pro Lys Leu Tyr Gln Val Leu
            20                  25                  30          
Asp Asp Gly Lys Arg Leu Leu Ile Ser Ile Ser Cys Ser Asp Leu Glu
        35                  40                  45              
Ser Gln Leu Asn Gln Leu Gly Glu Cys Trp Leu Ser Asn Thr Asn Lys
    50                  55                  60                  
Met Ser Lys Glu Leu His Arg Leu Glu Thr Ile Leu Lys His Trp Thr
65                  70                  75                  80  
Arg Tyr Gln Ser Glu Ser Ala Asp Leu Ile His Trp Leu Gln Ser Ala
                85                  90                  95      
Lys Asp Arg Leu Glu Phe Trp Thr Gln Gln Ser Val Thr Val Pro Gln
            100                 105                 110         
Glu Leu Asp Thr Gly Asn Gln Leu Leu Arg Leu Lys Lys Val Asp Thr
        115                 120                 125             
Ala Thr Leu Arg Ser Glu Leu Ser Arg Ile Asp Ser Gln Trp Thr Asp
    130                 135                 140                 
Leu Leu Thr Asn Ile Pro Ala Val Gln Glu Lys Leu His Gln Leu Gln
145                 150                 155                 160 
Met Asp Lys Leu Pro Ser Arg His Ala Ile Ser Glu Val Met Ser Trp
                165                 170                 175     
Ile Ser Leu Met Glu Asn Val Ile Gln Lys Asp Glu Asp Asn Ile Lys
            180                 185                 190         
Asn Ser Ile Gly Tyr Lys Ala Ile His Glu Tyr Leu Gln Lys Tyr Lys
        195                 200                 205             
Gly Phe Lys Ile Asp Ile Asn Cys Lys Gln Leu Thr Val Asp Phe Val
    210                 215                 220                 
Asn Gln Ser Val Leu Gln Ile Ser Ser Gln Asp Val Glu Ser Lys Arg
225                 230                 235                 240 
Ser Asp Lys Thr Asp Phe Ala Glu Gln Leu Gly Ala Met Asn Lys Ser
                245                 250                 255     
Trp Gln Ile Leu Gln Gly Leu Val Thr Glu Lys Ile Gln Leu Leu Glu
            260                 265                 270         
Gly Leu Leu Glu Ser Trp Ser Glu Tyr Glu Asn Asn Val Gln Cys Leu
        275                 280                 285             
Lys Thr Trp Phe Glu Thr Gln Glu Lys Arg Leu Lys Gln Gln His Arg
    290                 295                 300                 
Ile Gly Asp Gln Ala Ser Val Gln Asn Ala Leu Lys Asp Cys Gln Asp
305                 310                 315                 320 
Leu Glu Asp Leu Ile Lys Ala Lys Glu Lys Glu Val Glu Lys Ile Glu
                325                 330                 335     
Gln Asn Gly Leu Ala Leu Ile Gln Asn Lys Lys Glu Asp Val Ser Ser
            340                 345                 350         
Ile Val Met Ser Thr Leu Arg Glu Leu Gly Gln Thr Trp Ala Asn Leu
        355                 360                 365             
Asp His Met
    370     


<210> 1331
<211> 1117
<212> PRT
<213> Homo sapiens

<400> 1331
Met Arg Lys Leu Leu Ser Phe Gly Arg Arg Leu Gly Gln Ala Leu Leu
 1               5                  10                  15      
Ser Ser Met Asp Gln Glu Tyr Ala Gly Arg Gly Tyr His Ile Arg Asp
            20                  25                  30          
Trp Glu Leu Arg Lys Ile His Arg Ala Ala Ile Lys Gly Asp Ala Ala
        35                  40                  45              
Glu Val Glu His Cys Leu Thr Arg Arg Phe Arg Asp Leu Asp Val Arg
    50                  55                  60                  
Asp Arg Lys Asp Arg Thr Val Leu His Leu Ala Cys Ala His Gly Arg
65                  70                  75                  80  
Val Gln Val Val Thr Leu Leu Leu Asp Arg Lys Cys Gln Ile Asn Ile
                85                  90                  95      
Cys Asp Arg Leu Asn Arg Thr Pro Leu Met Lys Ala Val His Cys Gln
            100                 105                 110         
Glu Glu Ala Cys Ala Ile Ile Leu Leu Lys Arg Gly Ala Asn Pro Asn
        115                 120                 125             
Ile Lys Asp Ile Tyr Gly Asn Thr Ala Leu His Tyr Ala Val Tyr Asn
    130                 135                 140                 
Glu Gly Thr Ser Leu Ala Glu Arg Leu Leu Ser His His Ala Asn Ile
145                 150                 155                 160 
Glu Ala Leu Asn Lys Glu Gly Asn Thr Pro Leu Leu Phe Ala Ile Asn
                165                 170                 175     
Ser Arg Arg Gln His Met Val Glu Phe Leu Leu Lys Asn Gln Ala Asn
            180                 185                 190         
Ile His Ala Val Asp Asn Phe Lys Arg Thr Ala Leu Ile Leu Ala Val
        195                 200                 205             
Gln His Asn Leu Ser Ser Ile Val Thr Leu Leu Leu Gln Gln Asn Ile
    210                 215                 220                 
His Ile Ser Ser Gln Asp Met Phe Gly Gln Thr Ala Glu Asp Tyr Ala
225                 230                 235                 240 
Phe Cys Cys Asp Leu Arg Ser Ile Gln Gln Gln Ile Leu Glu His Lys
                245                 250                 255     
Asn Lys Met Leu Lys Asn His Leu Arg Asn Asp Asn Gln Glu Ala Ala
            260                 265                 270         
Ala Met Lys Asn Glu Ser Phe Lys Thr Gln Gly Ala Ser Ser Lys Val
        275                 280                 285             
Ser Leu Tyr His Gln Ser Gly Val Gln Trp His Asp Leu Arg Leu Leu
    290                 295                 300                 
Gln Pro Ser Pro Pro Arg Phe Lys Gln Phe Ser Cys Leu Ser Leu Pro
305                 310                 315                 320 
Arg Ser Trp Asp Asn Arg His Met Arg Pro Cys Pro Glu Thr Ala Ala
                325                 330                 335     
Met Lys Pro Glu Asn Leu Lys Lys Arg Lys Lys Arg Lys Lys Leu Lys
            340                 345                 350         
Lys Arg Lys Glu Gly Ala Lys Glu His Asn Leu Lys Val Ala Ser Glu
        355                 360                 365             
Glu Lys Gln Glu Arg Leu Glu Arg Ser Glu Asn Lys Gln Pro Gln Asp
    370                 375                 380                 
Ser Gln Ser Tyr Gly Lys Lys Lys Asp Glu Met Phe Gly Asn Phe Met
385                 390                 395                 400 
Leu Lys Arg Asp Ile Ala Met Leu Lys Glu Glu Leu Tyr Ala Ile Lys
                405                 410                 415     
Asn Asp Ser Leu Arg Lys Glu Lys Lys Tyr Ile Gln Glu Ile Lys Ser
            420                 425                 430         
Ile Thr Glu Ile Asn Ala Asn Phe Glu Lys Ser Val Arg Leu Asn Glu
        435                 440                 445             
Glu Met Ile Thr Lys Lys Val Ala Gln Tyr Ser Gln Gln Leu Asn Asp
    450                 455                 460                 
Leu Lys Ala Glu Asn Ala Arg Leu Asn Ser Lys Leu Glu Lys Glu Lys
465                 470                 475                 480 
His Asn Lys Glu Arg Leu Glu Ala Glu Val Glu Ser Leu His Ser Asn
                485                 490                 495     
Leu Ala Thr Ala Ile Asn Glu Tyr Asn Glu Ile Leu Glu Arg Lys Asp
            500                 505                 510         
Leu Glu Leu Val Leu Trp Arg Ala Asp Asp Val Ser Arg His Glu Thr
        515                 520                 525             
Met Gly Ser Asn Ile Ser Gln Leu Thr Asp Lys Asn Glu Leu Leu Thr
    530                 535                 540                 
Glu Gln Val His Lys Ala Arg Val Lys Phe Asn Thr Leu Lys Gly Lys
545                 550                 555                 560 
Leu Arg Glu Thr Arg Asp Ala Leu Arg Glu Lys Thr Leu Ala Leu Glu
                565                 570                 575     
Ser Val Gln Leu Asp Leu Lys Gln Ala Gln His Arg Ile Lys Glu Met
            580                 585                 590         
Lys Gln Met His Pro Asn Gly Glu Ala Lys Glu Ser Gln Ser Ile Gly
        595                 600                 605             
Lys Gln Asn Ser Ser Glu Glu Arg Ile Arg Gln Arg Glu Leu Glu Asn
    610                 615                 620                 
Leu Leu Leu Glu Arg Gln Leu Glu Asp Ala Arg Lys Glu Gly Asp Asn
625                 630                 635                 640 
Lys Glu Ile Val Ile Asn Ile His Arg Asp Cys Leu Glu Asn Gly Lys
                645                 650                 655     
Glu Asp Leu Leu Glu Glu Arg Asn Lys Glu Leu Met Asn Glu Tyr Asn
            660                 665                 670         
Tyr Leu Lys Glu Lys Leu Leu Gln Tyr Glu Lys Glu Lys Ala Glu Arg
        675                 680                 685             
Glu Val Ile Val Arg Glu Phe Gln Glu Glu Leu Val Asp His Leu Lys
    690                 695                 700                 
Lys Phe Ser Met Ser Glu Ser Pro Leu Glu Gly Thr Ser His Cys His
705                 710                 715                 720 
Ile Asn Leu Asp Glu Thr Trp Thr Ser Lys Lys Lys Leu Phe Gln Val
                725                 730                 735     
Glu Ile Gln Pro Glu Glu Lys His Glu Glu Phe Arg Lys Val Phe Glu
            740                 745                 750         
Leu Ile Ser Leu Leu Asn Tyr Thr Ala Asp Gln Ile Arg Lys Lys Asn
        755                 760                 765             
Arg Glu Leu Glu Glu Glu Ala Thr Gly Tyr Lys Lys Cys Leu Glu Met
    770                 775                 780                 
Thr Ile Asn Met Leu Asn Ala Phe Ala Asn Glu Asp Phe Ser Cys His
785                 790                 795                 800 
Gly Asp Leu Asn Thr Asp Gln Leu Lys Met Asp Ile Leu Phe Lys Lys
                805                 810                 815     
Leu Lys Gln Lys Phe Asp Asp Leu Met Ala Glu Lys Glu Ala Val Ser
            820                 825                 830         
Ser Lys Cys Val Asn Leu Ala Lys Asp Asn Glu Val Leu His Gln Glu
        835                 840                 845             
Leu Leu Ser Met Gly Lys Val Gln Glu Lys Cys Glu Lys Leu Glu Lys
    850                 855                 860                 
Asp Lys Lys Met Leu Glu Glu Lys Val Leu Asn Leu Lys Thr His Met
865                 870                 875                 880 
Glu Lys Asp Met Val Glu Leu Gly Lys Val Gln Glu Tyr Lys Ser Glu
                885                 890                 895     
Leu Asp Glu Arg Ala Met Gln Ala Ile Glu Lys Leu Glu Glu Ile His
            900                 905                 910         
Leu Gln Lys Gln Ala Glu Tyr Glu Lys Gln Leu Glu Gln Leu Asn Lys
        915                 920                 925             
Asp Asn Thr Ala Ser Leu Lys Lys Lys Glu Leu Thr Leu Lys Asp Val
    930                 935                 940                 
Glu Cys Lys Phe Ser Lys Met Lys Thr Ala Tyr Glu Asp Val Thr Thr
945                 950                 955                 960 
Glu Leu Glu Glu Tyr Lys Glu Ala Phe Ala Val Ala Leu Lys Ala Asn
                965                 970                 975     
Ser Ser Met Ser Glu Lys Ile Thr Lys Ser Asp Lys Lys Ile Ala Val
            980                 985                 990         
Ile Ser Thr Lys Leu Phe Met Glu Lys Glu Arg Met Glu Tyr Phe Leu
        995                 1000                1005            
Ser Thr Leu Pro Met Arg Pro Asp Pro Glu Leu Pro Cys Val Glu Asn
    1010                1015                1020                
Leu Asn Ser Ile Glu Leu Asn Arg Lys Tyr Ile Pro Lys Met Ala Ile
1025                1030                1035                1040
Arg Ile Pro Thr Ser Asn Pro Gln Thr Ser Asn Asn Cys Lys Asn Ser
                1045                1050                1055    
Leu Thr Glu Met Glu Leu Asp Cys Ala Glu Gln Ile Ile Thr Glu Thr
            1060                1065                1070        
Lys Lys Ile Ile Asn Leu Cys Ile Pro Ser Thr Arg Lys Pro Met Ile
        1075                1080                1085            
Leu Thr Gln Asn Phe Cys Cys Val Gly Pro Leu Leu Leu Ser Thr Phe
    1090                1095                1100                
Phe Ser Arg Ile His Cys Pro Arg Met Ser Asn Phe Ser
1105                1110                1115        


<210> 1332
<211> 903
<212> PRT
<213> Homo sapiens

<400> 1332
Met Ala Pro Thr Lys Pro Ser Phe Gln Gln Asp Pro Ser Arg Arg Glu
 1               5                  10                  15      
Arg Leu Gln Ala Leu Arg Lys Glu Lys Ser Arg Asp Ala Ala Arg Ser
            20                  25                  30          
Arg Arg Gly Lys Glu Asn Phe Glu Phe Tyr Glu Leu Ala Lys Leu Leu
        35                  40                  45              
Pro Leu Pro Ala Ala Ile Thr Ser Gln Leu Asp Lys Ala Ser Ile Ile
    50                  55                  60                  
Arg Leu Thr Ile Ser Tyr Leu Lys Met Arg Asp Phe Ala Asn Gln Gly
65                  70                  75                  80  
Asp Pro Pro Trp Asn Leu Arg Met Glu Gly Pro Pro Pro Asn Thr Ser
                85                  90                  95      
Val Lys Val Ile Gly Ala Gln Arg Arg Arg Ser Pro Ser Ala Leu Ala
            100                 105                 110         
Ile Glu Val Phe Glu Ala His Leu Gly Ser His Ile Leu Gln Ser Leu
        115                 120                 125             
Asp Gly Phe Val Phe Ala Leu Asn Gln Glu Gly Lys Phe Leu Tyr Ile
    130                 135                 140                 
Ser Glu Thr Val Ser Ile Tyr Leu Gly Leu Ser Gln Val Glu Leu Thr
145                 150                 155                 160 
Gly Ser Ser Val Phe Asp Tyr Val His Pro Gly Asp His Val Glu Met
                165                 170                 175     
Ala Glu Gln Leu Gly Met Lys Leu Pro Pro Gly Arg Gly Leu Leu Ser
            180                 185                 190         
Gln Gly Thr Ala Glu Asp Gly Ala Ser Ser Ala Ser Ser Ser Ser Gln
        195                 200                 205             
Ser Glu Thr Pro Glu Pro Val Glu Ser Thr Ser Pro Ser Leu Leu Thr
    210                 215                 220                 
Thr Asp Asn Thr Leu Glu Arg Ser Phe Phe Ile Arg Met Lys Ser Thr
225                 230                 235                 240 
Leu Thr Lys Arg Gly Val His Ile Lys Ser Ser Gly Tyr Lys Val Ile
                245                 250                 255     
His Ile Thr Gly Arg Leu Arg Leu Arg Val Ser Leu Ser His Gly Arg
            260                 265                 270         
Thr Val Pro Ser Gln Ile Met Gly Leu Val Val Val Ala His Ala Leu
        275                 280                 285             
Pro Pro Pro Thr Ile Asn Glu Val Arg Ile Asp Cys His Met Phe Val
    290                 295                 300                 
Thr Arg Val Asn Met Asp Leu Asn Ile Ile Tyr Cys Glu Asn Arg Ile
305                 310                 315                 320 
Ser Asp Tyr Met Asp Leu Thr Pro Val Asp Ile Val Gly Lys Arg Cys
                325                 330                 335     
Tyr His Phe Ile His Ala Glu Asp Val Glu Gly Ile Arg His Ser His
            340                 345                 350         
Leu Asp Leu Leu Asn Lys Gly Gln Cys Val Thr Lys Tyr Tyr Arg Trp
        355                 360                 365             
Met Gln Lys Asn Gly Gly Tyr Ile Trp Ile Gln Ser Ser Ala Thr Ile
    370                 375                 380                 
Ala Ile Asn Ala Lys Asn Ala Asn Glu Lys Asn Ile Ile Trp Val Asn
385                 390                 395                 400 
Tyr Leu Leu Ser Asn Pro Glu Tyr Lys Asp Thr Pro Met Asp Ile Ala
                405                 410                 415     
Gln Leu Pro His Leu Pro Glu Lys Thr Ser Glu Ser Ser Glu Thr Ser
            420                 425                 430         
Asp Ser Glu Ser Asp Ser Lys Asp Thr Ser Gly Ile Thr Glu Asp Asn
        435                 440                 445             
Glu Asn Ser Lys Ser Asp Glu Lys Gly Asn Gln Ser Glu Asn Ser Glu
    450                 455                 460                 
Asp Pro Glu Pro Asp Arg Lys Lys Ser Gly Asn Ala Cys Asp Asn Asp
465                 470                 475                 480 
Met Asn Cys Asn Asp Asp Gly His Ser Ser Ser Asn Pro Asp Ser Arg
                485                 490                 495     
Asp Ser Asp Asp Ser Phe Glu His Ser Asp Phe Glu Asn Pro Lys Ala
            500                 505                 510         
Gly Glu Asp Gly Phe Gly Ala Leu Gly Ala Met Gln Ile Lys Val Glu
        515                 520                 525             
Arg Tyr Val Glu Ser Glu Ser Asp Leu Arg Leu Gln Asn Cys Glu Ser
    530                 535                 540                 
Leu Thr Ser Asp Ser Ala Lys Asp Ser Asp Ser Ala Gly Glu Ala Gly
545                 550                 555                 560 
Ala Gln Ala Ser Ser Lys His Gln Lys Arg Lys Lys Arg Arg Lys Arg
                565                 570                 575     
Gln Lys Gly Gly Ser Ala Ser Arg Arg Arg Leu Ser Ser Ala Ser Ser
            580                 585                 590         
Pro Gly Gly Leu Asp Ala Gly Leu Val Glu Pro Pro Arg Leu Leu Ser
        595                 600                 605             
Ser Pro Asn Ser Ala Ser Val Leu Lys Ile Lys Thr Glu Ile Ser Glu
    610                 615                 620                 
Pro Ile Asn Phe Asp Asn Asp Ser Ser Ile Trp Asn Tyr Pro Pro Asn
625                 630                 635                 640 
Arg Glu Ile Ser Arg Asn Glu Ser Pro Tyr Ser Met Thr Lys Pro Pro
                645                 650                 655     
Ser Ser Glu His Phe Pro Ser Pro Gln Gly Gly Gly Gly Gly Gly Gly
            660                 665                 670         
Gly Gly Gly Gly Leu His Val Ala Ile Pro Asp Ser Val Leu Thr Pro
        675                 680                 685             
Pro Gly Ala Asp Gly Ala Ala Ala Arg Lys Thr Gln Phe Gly Ala Ser
    690                 695                 700                 
Ala Thr Ala Ala Leu Ala Pro Val Ala Ser Asp Pro Leu Ser Pro Pro
705                 710                 715                 720 
Leu Ser Ala Ser Pro Arg Asp Lys His Pro Gly Asn Gly Gly Gly Gly
                725                 730                 735     
Gly Gly Gly Gly Gly Gly Ala Gly Gly Gly Gly Pro Ser Ala Ser Asn
            740                 745                 750         
Ser Leu Leu Tyr Thr Gly Asp Leu Glu Ala Leu Gln Arg Leu Gln Ala
        755                 760                 765             
Gly Asn Val Val Leu Pro Leu Val His Arg Val Thr Gly Thr Leu Ala
    770                 775                 780                 
Ala Thr Ser Thr Ala Ala Gln Arg Val Tyr Thr Thr Gly Thr Ile Arg
785                 790                 795                 800 
Tyr Ala Pro Ala Glu Val Thr Leu Ala Met Gln Ser Asn Leu Leu Pro
                805                 810                 815     
Asn Ala His Ala Val Asn Phe Val Asp Val Asn Ser Pro Gly Phe Gly
            820                 825                 830         
Leu Asp Pro Lys Thr Pro Met Glu Met Leu Tyr His His Val His Arg
        835                 840                 845             
Leu Asn Met Ser Gly Pro Phe Gly Gly Ala Val Ser Ala Ala Ser Leu
    850                 855                 860                 
Thr Gln Met Pro Ala Gly Asn Val Phe Thr Thr Ala Glu Gly Leu Phe
865                 870                 875                 880 
Ser Thr Leu Pro Phe Pro Val Tyr Ser Asn Gly Ile His Ala Ala Gln
                885                 890                 895     
Thr Leu Glu Arg Lys Glu Asp
            900             


<210> 1333
<211> 1147
<212> PRT
<213> Homo sapiens

<400> 1333
Met Asp Asp Tyr Met Glu Thr Leu Lys Asp Glu Glu Asp Ala Leu Trp
 1               5                  10                  15      
Glu Asn Val Glu Cys Asn Arg His Met Leu Ser Arg Tyr Ile Asn Pro
            20                  25                  30          
Ala Lys Leu Thr Pro Tyr Leu Arg Gln Cys Lys Val Ile Asp Glu Gln
        35                  40                  45              
Asp Glu Asp Glu Val Leu Asn Ala Pro Met Leu Pro Ser Lys Ile Asn
    50                  55                  60                  
Arg Ala Gly Arg Leu Leu Asp Ile Leu His Thr Lys Gly Gln Arg Gly
65                  70                  75                  80  
Tyr Val Val Phe Leu Glu Ser Leu Glu Phe Tyr Tyr Pro Glu Leu Tyr
                85                  90                  95      
Lys Leu Val Thr Gly Lys Glu Pro Thr Arg Arg Phe Ser Thr Ile Val
            100                 105                 110         
Val Glu Glu Gly His Glu Gly Leu Thr His Phe Leu Met Asn Glu Val
        115                 120                 125             
Ile Lys Leu Gln Gln Gln Met Lys Ala Lys Asp Leu Gln Arg Cys Glu
    130                 135                 140                 
Leu Leu Ala Arg Leu Arg Gln Leu Glu Asp Glu Lys Lys Gln Met Thr
145                 150                 155                 160 
Leu Thr Arg Val Glu Leu Leu Thr Phe Gln Glu Arg Tyr Tyr Lys Met
                165                 170                 175     
Lys Glu Glu Arg Asp Ser Tyr Asn Asp Glu Leu Val Lys Val Lys Asp
            180                 185                 190         
Asp Asn Tyr Asn Leu Ala Met Arg Tyr Ala Gln Leu Ser Glu Glu Lys
        195                 200                 205             
Asn Met Ala Val Met Arg Ser Arg Asp Leu Gln Leu Glu Ile Asp Gln
    210                 215                 220                 
Leu Lys His Arg Leu Asn Lys Met Glu Glu Glu Cys Lys Leu Glu Arg
225                 230                 235                 240 
Asn Gln Ser Leu Lys Leu Lys Asn Asp Ile Glu Asn Arg Pro Lys Lys
                245                 250                 255     
Glu Gln Val Leu Glu Leu Glu Arg Glu Asn Glu Met Leu Lys Thr Lys
            260                 265                 270         
Asn Gln Glu Leu Gln Ser Ile Ile Gln Ala Gly Lys Arg Ser Leu Pro
        275                 280                 285             
Asp Ser Asp Lys Ala Ile Leu Asp Ile Leu Glu His Asp Arg Lys Glu
    290                 295                 300                 
Ala Leu Glu Asp Arg Gln Glu Leu Val Asn Arg Ile Tyr Asn Leu Gln
305                 310                 315                 320 
Glu Glu Ala Arg Gln Ala Glu Glu Leu Arg Asp Lys Tyr Leu Glu Glu
                325                 330                 335     
Lys Glu Asp Leu Glu Leu Lys Cys Ser Thr Leu Gly Lys Asp Cys Glu
            340                 345                 350         
Met Tyr Lys His Arg Met Asn Thr Val Met Leu Gln Leu Glu Glu Val
        355                 360                 365             
Glu Arg Glu Arg Asp Gln Ala Phe His Ser Arg Asp Glu Ala Gln Thr
    370                 375                 380                 
Gln Tyr Ser Gln Cys Leu Ile Glu Lys Asp Lys Tyr Arg Lys Gln Ile
385                 390                 395                 400 
Arg Glu Leu Glu Glu Lys Asn Asp Glu Met Arg Ile Glu Met Val Arg
                405                 410                 415     
Arg Glu Ala Cys Ile Val Asn Leu Glu Ser Lys Leu Arg Arg Leu Ser
            420                 425                 430         
Lys Asp Ser Asn Asn Leu Asp Gln Ser Leu Pro Arg Asn Leu Pro Val
        435                 440                 445             
Thr Ile Ile Ser Gln Asp Phe Gly Asp Ala Ser Pro Arg Thr Asn Gly
    450                 455                 460                 
Gln Glu Ala Asp Asp Ser Ser Thr Ser Glu Glu Ser Pro Glu Asp Ser
465                 470                 475                 480 
Lys Tyr Phe Leu Pro Tyr His Pro Pro Gln Arg Arg Met Asn Leu Lys
                485                 490                 495     
Gly Ile Gln Leu Gln Arg Ala Lys Ser Pro Ile Ser Leu Lys Arg Thr
            500                 505                 510         
Ser Asp Phe Gln Ala Lys Gly His Glu Glu Glu Gly Thr Asp Ala Ser
        515                 520                 525             
Pro Ser Ser Cys Gly Ser Leu Pro Ile Thr Asn Ser Phe Thr Lys Met
    530                 535                 540                 
Gln Pro Pro Arg Ser Arg Ser Ser Ile Met Ser Ile Thr Ala Glu Pro
545                 550                 555                 560 
Pro Gly Asn Asp Ser Ile Val Arg Arg Tyr Lys Glu Asp Ala Pro His
                565                 570                 575     
Arg Ser Thr Val Glu Glu Asp Asn Asp Ser Gly Gly Phe Asp Ala Leu
            580                 585                 590         
Asp Leu Asp Asp Asp Ser His Glu Arg Tyr Ser Phe Gly Pro Ser Ser
        595                 600                 605             
Ile His Ser Ser Ser Ser Ser His Gln Ser Glu Gly Leu Asp Ala Tyr
    610                 615                 620                 
Asp Leu Glu Gln Val Asn Leu Met Phe Arg Lys Phe Ser Leu Glu Arg
625                 630                 635                 640 
Pro Phe Arg Pro Ser Val Thr Ser Val Gly His Val Arg Gly Pro Gly
                645                 650                 655     
Pro Ser Val Gln His Thr Thr Leu Asn Gly Asp Ser Leu Thr Ser Gln
            660                 665                 670         
Leu Thr Leu Leu Gly Gly Asn Ala Arg Gly Ser Phe Val His Ser Val
        675                 680                 685             
Lys Pro Gly Ser Leu Ala Glu Lys Ala Gly Leu Arg Glu Gly His Gln
    690                 695                 700                 
Leu Leu Leu Leu Glu Gly Cys Ile Arg Gly Glu Arg Gln Ser Val Pro
705                 710                 715                 720 
Leu Asp Thr Cys Thr Lys Glu Glu Ala His Trp Thr Ile Gln Arg Cys
                725                 730                 735     
Ser Gly Pro Val Thr Leu His Tyr Lys Val Asn His Glu Gly Tyr Arg
            740                 745                 750         
Lys Leu Val Lys Asp Met Glu Asp Gly Leu Ile Thr Ser Gly Asp Ser
        755                 760                 765             
Phe Tyr Ile Arg Leu Asn Leu Asn Ile Ser Ser Gln Leu Asp Ala Cys
    770                 775                 780                 
Thr Met Ser Leu Lys Cys Asp Asp Val Val His Val Arg Asp Thr Met
785                 790                 795                 800 
Tyr Gln Asp Arg His Glu Trp Pro Cys Ala Arg Val Asp Pro Phe Thr
                805                 810                 815     
Asp His Asp Leu Asp Met Gly Thr Ile Pro Ser Tyr Ser Arg Ala Gln
            820                 825                 830         
Gln Leu Leu Leu Val Lys Leu Gln Arg Leu Met His Arg Gly Ser Arg
        835                 840                 845             
Glu Glu Val Asp Gly Thr His His Thr Leu Arg Ala Leu Arg Asn Thr
    850                 855                 860                 
Leu Gln Pro Glu Glu Ala Leu Ser Thr Ser Asp Pro Arg Val Ser Pro
865                 870                 875                 880 
Arg Leu Ser Arg Ala Ser Phe Leu Phe Gly Gln Leu Leu Gln Phe Val
                885                 890                 895     
Ser Arg Ser Glu Asn Lys Tyr Lys Arg Met Asn Ser Asn Glu Arg Val
            900                 905                 910         
Arg Ile Ile Ser Gly Ser Pro Leu Gly Ser Leu Ala Arg Ser Ser Leu
        915                 920                 925             
Asp Ala Thr Lys Leu Leu Thr Glu Lys Gln Glu Glu Leu Asp Pro Glu
    930                 935                 940                 
Ser Glu Leu Gly Lys Asn Leu Ser Leu Ile Pro Tyr Ser Leu Val Arg
945                 950                 955                 960 
Ala Phe Tyr Cys Glu Arg Arg Arg Pro Val Leu Phe Thr Pro Thr Val
                965                 970                 975     
Leu Ala Lys Thr Leu Val Gln Arg Leu Leu Asn Ser Gly Gly Ala Met
            980                 985                 990         
Glu Phe Thr Ile Cys Lys Ser Asp Ile Val Thr Arg Asp Glu Phe Leu
        995                 1000                1005            
Arg Arg Gln Lys Thr Glu Thr Ile Ile Tyr Ser Arg Glu Lys Asn Pro
    1010                1015                1020                
Asn Ala Phe Glu Cys Ile Ala Pro Ala Asn Ile Glu Ala Val Ala Ala
1025                1030                1035                1040
Lys Asn Lys His Cys Leu Leu Glu Ala Gly Ile Gly Cys Thr Arg Asp
                1045                1050                1055    
Leu Ile Lys Ser Asn Ile Tyr Pro Ile Val Leu Phe Ile Arg Val Cys
            1060                1065                1070        
Glu Lys Asn Ile Lys Arg Phe Arg Lys Leu Leu Pro Arg Pro Glu Thr
        1075                1080                1085            
Glu Glu Glu Phe Leu Arg Val Cys Arg Leu Lys Glu Lys Glu Leu Glu
    1090                1095                1100                
Ala Leu Pro Cys Leu Tyr Ala Thr Val Glu Pro Asp Met Trp Gly Ser
1105                1110                1115                1120
Val Glu Glu Leu Leu Arg Val Val Lys Asp Lys Ile Gly Glu Glu Gln
                1125                1130                1135    
Arg Lys Thr Ile Trp Val Asp Glu Asp Gln Leu
            1140                1145        


<210> 1334
<211> 842
<212> PRT
<213> Homo sapiens

<400> 1334
Met Asp Phe Gln Glu Arg Asp Pro Pro Phe Leu Pro Glu Ser Ala Gln
 1               5                  10                  15      
Ser Ser Lys Pro Ser Ser Ala Gln Gln Ala Ser Glu Leu Trp Glu Val
            20                  25                  30          
Val Glu Glu Pro Arg Val Arg Leu Gly Thr Glu Gly Val Met Pro Glu
        35                  40                  45              
Arg Gln Glu Gly His Leu Leu Lys Lys Arg Lys Trp Pro Leu Lys Gly
    50                  55                  60                  
Trp His Lys Arg Tyr Phe Val Leu Glu Asp Gly Ile Leu His Tyr Ala
65                  70                  75                  80  
Thr Thr Arg Gln Asp Ile Thr Lys Gly Lys Leu His Gly Ser Ile Asp
                85                  90                  95      
Val Arg Leu Ser Val Met Ser Ile Asn Lys Lys Ala Gln Arg Ile Asp
            100                 105                 110         
Leu Asp Thr Glu Asp Asn Ile Tyr His Leu Lys Ile Lys Ser Gln Asp
        115                 120                 125             
Leu Phe Gln Ser Trp Val Ala Gln Leu Arg Ala His Arg Leu Ala His
    130                 135                 140                 
Arg Leu Asp Met Pro Arg Gly Ser Leu Pro Ser Thr Ala His Arg Lys
145                 150                 155                 160 
Val Pro Gly Ala Gln Leu Pro Thr Ala Ala Thr Ala Ser Ala Leu Pro
                165                 170                 175     
Gly Leu Gly Pro Arg Glu Lys Val Ser Ser Trp Leu Arg Asp Ser Asp
            180                 185                 190         
Gly Leu Asp Arg Cys Ser His Glu Leu Ser Glu Cys Gln Gly Lys Leu
        195                 200                 205             
Gln Glu Leu His Arg Leu Leu Gln Ser Leu Glu Ser Leu His Arg Ile
    210                 215                 220                 
Pro Ser Ala Pro Val Ile Pro Thr His Gln Ala Ser Val Thr Thr Glu
225                 230                 235                 240 
Arg Pro Lys Lys Gly Lys Arg Thr Ser Arg Met Trp Cys Thr Gln Ser
                245                 250                 255     
Phe Ala Lys Asp Asp Thr Ile Gly Arg Val Gly Arg Leu His Gly Ser
            260                 265                 270         
Val Pro Asn Leu Ser Arg Tyr Leu Glu Ser Arg Asp Ser Ser Gly Thr
        275                 280                 285             
Arg Gly Leu Pro Pro Thr Asp Tyr Ala His Leu Gln Arg Ser Phe Trp
    290                 295                 300                 
Ala Leu Ala Gln Lys Val His Ser Ser Leu Ser Ser Val Leu Ala Ala
305                 310                 315                 320 
Leu Thr Met Glu Arg Asp Gln Leu Arg Asp Met His Gln Gly Ser Glu
                325                 330                 335     
Leu Ser Arg Met Gly Val Ser Glu Ala Ser Thr Gly Gln Arg Arg Leu
            340                 345                 350         
His Ser Leu Ser Thr Ser Ser Asp Thr Thr Ala Asp Ser Phe Ser Ser
        355                 360                 365             
Leu Asn Pro Glu Glu Gln Glu Ala Leu Tyr Met Lys Gly Arg Glu Leu
    370                 375                 380                 
Thr Pro Gln Leu Ser Gln Thr Ser Ile Leu Ser Leu Ala Asp Ser His
385                 390                 395                 400 
Thr Glu Phe Phe Asp Ala Cys Glu Val Leu Leu Ser Ala Ser Ser Ser
                405                 410                 415     
Glu Asn Glu Gly Ser Glu Glu Glu Glu Ser Cys Thr Ser Glu Ile Thr
            420                 425                 430         
Thr Ser Leu Ser Glu Glu Met Leu Asp Leu Arg Gly Ala Glu Arg Cys
        435                 440                 445             
Gln Lys Gly Gly Cys Val Pro Gly Arg Pro Met Gly Pro Pro Arg Arg
    450                 455                 460                 
Arg Cys Leu Pro Ala Ala Ser Gly Pro Gly Ala Asp Val Ser Leu Trp
465                 470                 475                 480 
Asn Ile Leu Arg Asn Asn Ile Gly Lys Asp Leu Ser Lys Val Ser Met
                485                 490                 495     
Pro Val Gln Leu Asn Glu Pro Leu Asn Thr Leu Gln Arg Leu Cys Glu
            500                 505                 510         
Glu Leu Glu Tyr Ser Ser Leu Leu Asp Gln Ala Ser Arg Ile Ala Asp
        515                 520                 525             
Pro Cys Glu Arg Met Val Tyr Ile Ala Ala Phe Ala Val Ser Ala Tyr
    530                 535                 540                 
Ser Ser Thr Tyr His Arg Ala Gly Cys Lys Pro Phe Asn Pro Val Leu
545                 550                 555                 560 
Gly Glu Thr Tyr Glu Cys Glu Arg Pro Asp Arg Gly Phe Arg Phe Ile
                565                 570                 575     
Ser Glu Gln Val Ser His His Pro Pro Ile Ser Ala Cys His Ala Glu
            580                 585                 590         
Ser Glu Asn Phe Ala Phe Trp Gln Asp Met Lys Trp Lys Asn Lys Phe
        595                 600                 605             
Trp Gly Lys Ser Leu Glu Ile Val Pro Val Gly Thr Val Asn Val Ser
    610                 615                 620                 
Leu Pro Arg Phe Gly Asp His Phe Glu Trp Asn Lys Val Thr Ser Cys
625                 630                 635                 640 
Ile His Asn Val Leu Ser Gly Gln Arg Trp Ile Glu His Tyr Gly Glu
                645                 650                 655     
Val Leu Ile Arg Asn Thr Gln Asp Ser Ser Cys His Cys Lys Ile Thr
            660                 665                 670         
Phe Cys Lys Ala Lys Tyr Trp Ser Ser Asn Val His Glu Val Gln Gly
        675                 680                 685             
Ala Val Leu Ser Arg Ser Gly Arg Val Leu His Arg Leu Phe Gly Lys
    690                 695                 700                 
Trp His Glu Gly Leu Tyr Arg Gly Pro Thr Pro Gly Gly Gln Cys Ile
705                 710                 715                 720 
Trp Lys Pro Asn Ser Met Pro Pro Asp His Glu Arg Asn Phe Gly Phe
                725                 730                 735     
Thr Gln Phe Ala Leu Glu Leu Asn Glu Leu Thr Ala Glu Leu Lys Arg
            740                 745                 750         
Ser Leu Pro Ser Thr Asp Thr Arg Leu Arg Pro Asp Gln Arg Tyr Leu
        755                 760                 765             
Glu Glu Gly Asn Ile Gln Ala Ala Glu Ala Gln Lys Arg Arg Ile Glu
    770                 775                 780                 
Gln Leu Gln Arg Asp Arg Arg Lys Val Met Glu Glu Asn Asn Ile Val
785                 790                 795                 800 
His Gln Ala Arg Phe Phe Arg Arg Gln Thr Asp Ser Ser Gly Lys Glu
                805                 810                 815     
Trp Trp Val Thr Asn Asn Thr Tyr Trp Arg Leu Arg Ala Glu Pro Gly
            820                 825                 830         
Tyr Gly Asn Met Asp Gly Ala Val Leu Trp
        835                 840         


<210> 1335
<211> 852
<212> PRT
<213> Homo sapiens

<400> 1335
Met Leu Pro Gly Thr Ser Thr Gly Asn Asn Gln Ser Thr Ile Thr Leu
 1               5                  10                  15      
Ser Val Ala Ser Gln Asn Leu Thr Phe Thr Ser Ser Ser Ser Pro Pro
            20                  25                  30          
Asn Gly Asp Ser Ile Asn Lys Asp Pro Lys Leu Cys Thr Lys Ser Pro
        35                  40                  45              
Arg Lys Arg Leu Ser Ser Thr Leu Gln Glu Thr Gln Val Pro Pro Val
    50                  55                  60                  
Lys Lys Pro Ile Val Glu Gln Leu Ser Ala Ala Thr Ile Glu Gly Gln
65                  70                  75                  80  
Lys Gln Gly Ser Val Lys Lys Asp Gln Lys Val Pro His Ser Gly Lys
                85                  90                  95      
Thr Glu Gly Ser Thr Ala Gly Ala Gln Ile Pro Ser Lys Val Ser Val
            100                 105                 110         
Asn Val Ser Ser His Ile Gly Ala Asn Gln Pro Leu Asn Ser Ser Ala
        115                 120                 125             
Leu Val Ile Ser Asp Ser Ala Leu Glu Gln Gln Thr Thr Pro Ser Ser
    130                 135                 140                 
Ser Pro Asp Ile Lys Val Lys Leu Glu Gly Ser Val Phe Leu Leu Asp
145                 150                 155                 160 
Ser Asp Ser Lys Ser Val Gly Ser Phe Asn Pro Asn Gly Trp Gln Gln
                165                 170                 175     
Ile Thr Lys Asp Ser Glu Phe Ile Ser Ala Ser Cys Glu Gln Gln Gln
            180                 185                 190         
Asp Ile Ser Val Met Thr Ile Pro Glu His Ser Asp Ile Asn Asp Leu
        195                 200                 205             
Glu Lys Ser Val Trp Glu Leu Glu Gly Met Pro Gln Asp Thr Tyr Ser
    210                 215                 220                 
Gln Gln Leu His Ser Gln Ile Gln Glu Ser Ser Leu Asn Gln Ile Gln
225                 230                 235                 240 
Ala His Ser Ser Asp Gln Leu Pro Leu Gln Ser Glu Leu Lys Glu Phe
                245                 250                 255     
Glu Pro Ser Val Ser Gln Thr Asn Glu Ser Tyr Phe Pro Phe Asp Asp
            260                 265                 270         
Glu Leu Thr Gln Asp Ser Ile Val Glu Glu Leu Val Leu Met Glu Gln
        275                 280                 285             
Gln Met Ser Met Asn Asn Ser His Ser Tyr Gly Asn Cys Leu Gly Met
    290                 295                 300                 
Thr Leu Gln Ser Gln Ser Val Thr Pro Gly Ala Pro Met Ser Ser His
305                 310                 315                 320 
Thr Ser Ser Thr His Phe Tyr His Pro Ile His Ser Asn Gly Thr Pro
                325                 330                 335     
Ile His Thr Pro Thr Pro Thr Pro Thr Pro Thr Pro Thr Pro Thr Pro
            340                 345                 350         
Thr Pro Thr Pro Thr Ser Glu Met Ile Ala Gly Ser Gln Ser Leu Ser
        355                 360                 365             
Arg Glu Ser Pro Cys Ser Arg Leu Ala Gln Thr Thr Pro Val Asp Ser
    370                 375                 380                 
Ala Leu Gly Ser Ser Arg His Thr Pro Ile Gly Thr Pro His Ser Asn
385                 390                 395                 400 
Cys Ser Ser Ser Val Pro Pro Ser Pro Val Glu Cys Arg Asn Pro Phe
                405                 410                 415     
Ala Phe Thr Pro Ile Ser Ser Ser Met Ala Tyr His Asp Ala Ser Ile
            420                 425                 430         
Val Ser Ser Ser Pro Val Lys Pro Met Gln Arg Pro Met Ala Thr His
        435                 440                 445             
Pro Asp Lys Thr Lys Leu Glu Trp Met Asn Asn Gly Tyr Ser Gly Val
    450                 455                 460                 
Gly Asn Ser Ser Val Ser Gly His Gly Ile Leu Pro Ser Tyr Gln Glu
465                 470                 475                 480 
Leu Val Glu Asp Arg Phe Arg Lys Pro His Ala Phe Ala Val Pro Gly
                485                 490                 495     
Gln Ser Tyr Gln Ser Gln Ser Arg His His Asp Thr His Phe Gly Arg
            500                 505                 510         
Leu Thr Pro Val Ser Pro Val Gln His Gln Gly Ala Thr Val Asn Asn
        515                 520                 525             
Thr Asn Lys Gln Glu Gly Phe Ala Val Pro Ala Pro Leu Asp Asn Lys
    530                 535                 540                 
Gly Thr Asn Ser Ser Ala Ser Ser Asn Phe Arg Cys Arg Ser Val Ser
545                 550                 555                 560 
Pro Ala Val His Arg Gln Arg Asn Leu Ser Gly Ser Thr Leu Tyr Pro
                565                 570                 575     
Val Ser Asn Ile Pro Arg Ser Asn Val Thr Pro Phe Gly Ser Pro Val
            580                 585                 590         
Thr Pro Glu Val His Val Phe Thr Asn Val His Thr Asp Ala Cys Ala
        595                 600                 605             
Asn Asn Ile Ala Gln Arg Ser Gln Ser Val Pro Leu Thr Val Met Met
    610                 615                 620                 
Gln Thr Ala Phe Pro Asn Ala Leu Gln Lys Gln Ala Asn Ser Lys Lys
625                 630                 635                 640 
Ile Thr Asn Val Leu Leu Ser Lys Leu Asp Ser Asp Asn Asp Asp Ala
                645                 650                 655     
Val Arg Gly Leu Gly Met Asn Asn Leu Pro Ser Asn Tyr Thr Ala Arg
            660                 665                 670         
Met Asn Leu Thr Gln Ile Leu Glu Pro Ser Thr Val Phe Pro Ser Ala
        675                 680                 685             
Asn Pro Gln Asn Met Ile Asp Ser Ser Thr Ser Val Tyr Glu Phe Gln
    690                 695                 700                 
Thr Pro Ser Tyr Leu Thr Lys Ser Asn Ser Thr Gly Gln Ile Asn Phe
705                 710                 715                 720 
Ser Pro Gly Asp Asn Gln Ala Gln Ser Glu Ile Gly Glu Gln Gln Leu
                725                 730                 735     
Asp Phe Asn Ser Thr Val Lys Asp Leu Leu Ser Gly Asp Ser Leu Gln
            740                 745                 750         
Thr Asn Gln Gln Leu Val Gly Gln Gly Ala Ser Asp Leu Thr Asn Thr
        755                 760                 765             
Ala Ser Asp Phe Ser Ser Asp Ile Arg Leu Ser Ser Glu Leu Ser Gly
    770                 775                 780                 
Ser Ile Asn Asp Leu Asn Thr Leu Asp Pro Asn Leu Leu Phe Asp Pro
785                 790                 795                 800 
Gly Arg Gln Gln Gly Gln Asp Asp Glu Ala Thr Leu Glu Glu Leu Lys
                805                 810                 815     
Asn Asp Pro Leu Phe Gln Gln Ile Cys Ser Glu Ser Met Asn Ser Met
            820                 825                 830         
Thr Ser Ser Gly Phe Glu Trp Ile Glu Ser Lys Asp His Pro Thr Val
        835                 840                 845             
Glu Met Leu Gly
    850         


<210> 1336
<211> 664
<212> PRT
<213> Homo sapiens

<400> 1336
Met Glu Glu Met Glu Glu Glu Leu Lys Cys Pro Val Cys Gly Ser Phe
 1               5                  10                  15      
Tyr Arg Glu Pro Ile Ile Leu Pro Cys Ser His Asn Leu Cys Gln Ala
            20                  25                  30          
Cys Ala Arg Asn Ile Leu Val Gln Thr Pro Glu Ser Glu Ser Pro Gln
        35                  40                  45              
Ser His Arg Ala Ala Gly Ser Gly Val Ser Asp Tyr Asp Tyr Leu Asp
    50                  55                  60                  
Leu Asp Lys Met Ser Leu Tyr Ser Glu Ala Asp Ser Gly Tyr Gly Ser
65                  70                  75                  80  
Tyr Gly Gly Phe Ala Ser Ala Pro Thr Thr Pro Cys Gln Lys Ser Pro
                85                  90                  95      
Asn Gly Val Arg Val Phe Pro Pro Ala Met Pro Pro Pro Ala Thr His
            100                 105                 110         
Leu Ser Pro Ala Leu Ala Pro Val Pro Arg Asn Ser Cys Ile Thr Cys
        115                 120                 125             
Pro Gln Cys His Arg Ser Leu Ile Leu Asp Asp Arg Gly Leu Arg Gly
    130                 135                 140                 
Phe Pro Lys Asn Arg Val Leu Glu Gly Val Ile Asp Arg Tyr Gln Gln
145                 150                 155                 160 
Ser Lys Ala Ala Ala Leu Lys Cys Gln Leu Cys Glu Lys Ala Pro Lys
                165                 170                 175     
Glu Ala Thr Val Met Cys Glu Gln Cys Asp Val Phe Tyr Cys Asp Pro
            180                 185                 190         
Cys Arg Leu Arg Cys His Pro Pro Arg Gly Pro Leu Ala Lys His Arg
        195                 200                 205             
Leu Val Pro Pro Ala Gln Gly Arg Val Ser Arg Arg Leu Ser Pro Arg
    210                 215                 220                 
Lys Val Ser Thr Cys Thr Asp His Glu Leu Glu Asn His Ser Met Tyr
225                 230                 235                 240 
Cys Val Gln Cys Lys Met Pro Val Cys Tyr Gln Cys Leu Glu Glu Gly
                245                 250                 255     
Lys His Ser Ser His Glu Val Lys Ala Leu Gly Ala Met Trp Lys Leu
            260                 265                 270         
His Lys Ser Gln Leu Ser Gln Ala Leu Asn Gly Leu Ser Asp Arg Ala
        275                 280                 285             
Lys Glu Ala Lys Glu Phe Leu Val Gln Leu Arg Asn Met Val Gln Gln
    290                 295                 300                 
Ile Gln Glu Asn Ser Val Glu Phe Glu Ala Cys Leu Val Ala Gln Cys
305                 310                 315                 320 
Asp Ala Leu Ile Asp Ala Leu Asn Arg Arg Lys Ala Gln Leu Leu Ala
                325                 330                 335     
Arg Val Asn Lys Glu His Glu His Lys Leu Lys Val Val Arg Asp Gln
            340                 345                 350         
Ile Ser His Cys Thr Val Lys Leu Arg Gln Thr Thr Gly Leu Met Glu
        355                 360                 365             
Tyr Cys Leu Glu Val Ile Lys Glu Asn Asp Pro Ser Gly Phe Leu Gln
    370                 375                 380                 
Ile Ser Asp Ala Leu Ile Arg Arg Val His Leu Thr Glu Asp Gln Trp
385                 390                 395                 400 
Gly Lys Gly Thr Leu Thr Pro Arg Met Thr Thr Asp Phe Asp Leu Ser
                405                 410                 415     
Leu Asp Asn Ser Pro Leu Leu Gln Ser Ile His Gln Leu Asp Phe Val
            420                 425                 430         
Gln Val Lys Ala Ser Ser Pro Val Pro Ala Thr Pro Ile Leu Gln Leu
        435                 440                 445             
Glu Glu Cys Cys Thr His Asn Asn Ser Ala Thr Leu Ser Trp Lys Gln
    450                 455                 460                 
Pro Pro Leu Ser Thr Val Pro Ala Asp Gly Tyr Ile Leu Glu Leu Asp
465                 470                 475                 480 
Asp Gly Asn Gly Gly Gln Phe Arg Glu Val Tyr Val Gly Lys Glu Thr
                485                 490                 495     
Met Cys Thr Val Asp Gly Leu His Phe Asn Ser Thr Tyr Asn Ala Arg
            500                 505                 510         
Val Lys Ala Phe Asn Lys Thr Gly Val Ser Pro Tyr Ser Lys Thr Leu
        515                 520                 525             
Val Leu Gln Thr Ser Glu Val Ala Trp Phe Ala Phe Asp Pro Gly Ser
    530                 535                 540                 
Ala His Ser Asp Ile Ile Leu Ser Asn Asp Asn Leu Thr Val Thr Cys
545                 550                 555                 560 
Ser Ser Tyr Asp Asp Arg Val Val Leu Gly Lys Thr Gly Phe Ser Lys
                565                 570                 575     
Gly Ile His Tyr Trp Glu Leu Thr Val Asp Arg Tyr Asp Asn His Pro
            580                 585                 590         
Asp Pro Ala Phe Gly Val Ala Arg Met Asp Val Met Lys Asp Val Met
        595                 600                 605             
Leu Gly Lys Asp Asp Lys Ala Trp Ala Met Tyr Val Asp Asn Asn Arg
    610                 615                 620                 
Ser Trp Phe Met His Asn Asn Ser His Thr Asn Arg Thr Glu Gly Gly
625                 630                 635                 640 
Ile Thr Lys Gly Ala Thr Ile Gly Val Leu Leu Asp Phe Asn Arg Lys
                645                 650                 655     
Asn Leu Thr Phe Phe Tyr Gln Arg
            660                 


<210> 1337
<211> 714
<212> PRT
<213> Homo sapiens

<400> 1337
Met Ser Glu Glu Ile Ile Thr Pro Val Tyr Cys Thr Gly Val Ser Ala
 1               5                  10                  15      
Gln Val Gln Lys Gln Arg Ala Arg Glu Leu Gly Leu Gly Arg His Glu
            20                  25                  30          
Asn Ala Ile Lys Tyr Leu Gly Gln Asp Tyr Glu Gln Leu Arg Val Arg
        35                  40                  45              
Cys Leu Gln Ser Gly Thr Leu Phe Arg Asp Glu Ala Phe Pro Pro Val
    50                  55                  60                  
Pro Gln Ser Leu Gly Tyr Lys Asp Leu Gly Pro Asn Ser Ser Lys Thr
65                  70                  75                  80  
Tyr Gly Ile Lys Trp Lys Arg Pro Thr Glu Leu Leu Ser Asn Pro Gln
                85                  90                  95      
Phe Ile Val Asp Gly Ala Thr Arg Thr Asp Ile Cys Gln Gly Ala Leu
            100                 105                 110         
Gly Asp Cys Trp Leu Leu Ala Ala Ile Ala Ser Leu Thr Leu Asn Asp
        115                 120                 125             
Thr Leu Leu His Arg Val Val Pro His Gly Gln Ser Phe Gln Asn Gly
    130                 135                 140                 
Tyr Ala Gly Ile Phe His Phe Gln Leu Trp Gln Phe Gly Glu Trp Val
145                 150                 155                 160 
Asp Val Val Val Asp Asp Leu Leu Pro Ile Lys Asp Gly Lys Leu Val
                165                 170                 175     
Phe Val His Ser Ala Glu Gly Asn Glu Phe Trp Ser Ala Leu Leu Glu
            180                 185                 190         
Lys Ala Tyr Ala Lys Val Asn Gly Ser Tyr Glu Ala Leu Ser Gly Gly
        195                 200                 205             
Ser Thr Ser Glu Gly Phe Glu Asp Phe Thr Gly Gly Val Thr Glu Trp
    210                 215                 220                 
Tyr Glu Leu Arg Lys Ala Pro Ser Asp Leu Tyr Gln Ile Ile Leu Lys
225                 230                 235                 240 
Ala Leu Glu Arg Gly Ser Leu Leu Gly Cys Ser Ile Asp Ile Ser Ser
                245                 250                 255     
Val Leu Asp Met Glu Ala Ile Thr Phe Lys Lys Leu Val Lys Gly His
            260                 265                 270         
Ala Tyr Ser Val Thr Gly Ala Lys Gln Val Asn Tyr Arg Gly Gln Val
        275                 280                 285             
Val Ser Leu Ile Arg Met Arg Asn Pro Trp Gly Glu Val Glu Trp Thr
    290                 295                 300                 
Gly Ala Trp Ser Asp Ser Ser Ser Glu Trp Asn Asn Val Asp Pro Tyr
305                 310                 315                 320 
Glu Arg Asp Gln Leu Arg Val Lys Met Glu Asp Gly Glu Phe Trp Met
                325                 330                 335     
Ser Phe Arg Asp Phe Met Arg Glu Phe Thr Arg Leu Glu Ile Cys Asn
            340                 345                 350         
Leu Thr Pro Asp Ala Leu Lys Ser Arg Thr Ile Arg Lys Trp Asn Thr
        355                 360                 365             
Thr Leu Tyr Glu Gly Thr Trp Arg Arg Gly Ser Thr Ala Gly Gly Cys
    370                 375                 380                 
Arg Asn Tyr Pro Ala Thr Phe Trp Val Asn Pro Gln Phe Lys Ile Arg
385                 390                 395                 400 
Leu Asp Glu Thr Asp Asp Pro Asp Asp Tyr Gly Asp Arg Glu Ser Gly
                405                 410                 415     
Cys Ser Phe Val Leu Ala Leu Met Gln Lys His Arg Arg Arg Glu Arg
            420                 425                 430         
Arg Phe Gly Arg Asp Met Glu Thr Ile Gly Phe Ala Val Tyr Glu Val
        435                 440                 445             
Pro Pro Glu Leu Val Gly Gln Pro Ala Val His Leu Lys Arg Asp Phe
    450                 455                 460                 
Phe Leu Ala Asn Ala Ser Arg Ala Arg Ser Glu Gln Phe Ile Asn Leu
465                 470                 475                 480 
Arg Glu Val Ser Thr Arg Phe Arg Leu Pro Pro Gly Glu Tyr Val Val
                485                 490                 495     
Val Pro Ser Thr Phe Glu Pro Asn Lys Glu Gly Asp Phe Val Leu Arg
            500                 505                 510         
Phe Phe Ser Glu Lys Ser Ala Gly Thr Val Glu Leu Asp Asp Gln Ile
        515                 520                 525             
Gln Ala Asn Leu Pro Asp Glu Gln Val Leu Ser Glu Glu Glu Ile Asp
    530                 535                 540                 
Glu Asn Phe Lys Ala Leu Phe Arg Gln Leu Ala Gly Glu Asp Met Glu
545                 550                 555                 560 
Ile Ser Val Lys Glu Leu Arg Thr Ile Leu Asn Arg Ile Ile Ser Lys
                565                 570                 575     
His Lys Asp Leu Arg Thr Lys Gly Phe Ser Leu Glu Ser Cys Arg Ser
            580                 585                 590         
Met Val Asn Leu Met Asp Arg Asp Gly Asn Gly Lys Leu Gly Leu Val
        595                 600                 605             
Glu Phe Asn Ile Leu Trp Asn Arg Ile Arg Asn Tyr Leu Ser Ile Phe
    610                 615                 620                 
Arg Lys Phe Asp Leu Asp Lys Ser Gly Ser Met Ser Ala Tyr Glu Met
625                 630                 635                 640 
Arg Met Ala Ile Glu Ser Ala Gly Phe Lys Leu Asn Lys Lys Leu Tyr
                645                 650                 655     
Glu Leu Ile Ile Thr Arg Tyr Ser Glu Pro Asp Leu Ala Val Asp Phe
            660                 665                 670         
Asp Asn Phe Val Cys Cys Leu Val Arg Leu Glu Thr Met Phe Arg Phe
        675                 680                 685             
Phe Lys Thr Leu Asp Thr Asp Leu Asp Gly Val Val Thr Phe Asp Leu
    690                 695                 700                 
Phe Lys Trp Leu Gln Leu Thr Met Phe Ala
705                 710                 


<210> 1338
<211> 247
<212> PRT
<213> Homo sapiens

<400> 1338
Met Glu Glu Gln Pro Gln Met Gln Asp Ala Asp Glu Pro Ala Asp Ser
 1               5                  10                  15      
Gly Gly Glu Gly Arg Ala Gly Gly Pro Pro Gln Val Ala Gly Ala Gln
            20                  25                  30          
Ala Ala Cys Ser Glu Asp Arg Met Thr Leu Leu Leu Arg Leu Arg Ala
        35                  40                  45              
Gln Thr Lys Gln Gln Leu Leu Glu Tyr Lys Ser Met Val Asp Ala Ser
    50                  55                  60                  
Glu Glu Lys Thr Pro Glu Gln Ile Met Gln Glu Lys Gln Ile Glu Ala
65                  70                  75                  80  
Lys Ile Glu Asp Leu Glu Asn Glu Ile Glu Glu Val Lys Val Ala Phe
                85                  90                  95      
Glu Ile Lys Lys Leu Ala Leu Asp Arg Met Arg Leu Ser Thr Ala Leu
            100                 105                 110         
Lys Lys Asn Leu Glu Lys Ile Ser Arg Gln Ser Ser Val Leu Met Asp
        115                 120                 125             
Asn Met Lys His Leu Leu Glu Leu Asn Lys Leu Ile Met Lys Ser Gln
    130                 135                 140                 
Gln Glu Ser Trp Asp Leu Glu Glu Lys Leu Leu Asp Ile Arg Lys Lys
145                 150                 155                 160 
Arg Leu Gln Leu Lys Gln Ala Ser Glu Ser Lys Leu Leu Glu Ile Gln
                165                 170                 175     
Thr Glu Lys Asn Lys Gln Lys Ile Asp Leu Asp Ser Met Glu Asn Ser
            180                 185                 190         
Glu Arg Ile Lys Ile Ile Arg Gln Asn Leu Gln Met Glu Ile Lys Ile
        195                 200                 205             
Thr Thr Val Ile Gln His Val Phe Gln Asn Leu Ile Leu Gly Ser Lys
    210                 215                 220                 
Val Asn Trp Ala Glu Asp Pro Ala Leu Lys Glu Ile Val Leu Gln Leu
225                 230                 235                 240 
Glu Lys Asn Val Asp Met Met
                245         


<210> 1339
<211> 900
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 31, 120
<223> Xaa = Any Amino Acid

<400> 1339
Met Ser Ser Lys Glu Ser Cys Gly Lys Lys Glu Thr Ser Gln Arg Lys
 1               5                  10                  15      
Asp Thr Thr Thr Ser Ser Pro Asn Phe Gly Glu Lys Asp Lys Xaa Glu
            20                  25                  30          
Arg Lys Thr Pro Ala Ser Ser Thr Ser Ser Ser Ser Ile Arg Ser Val
        35                  40                  45              
Ser Ser Glu Lys Arg Lys Leu Lys Ser Asp His Thr Asp Val Leu Tyr
    50                  55                  60                  
Tyr Asn Ile Lys Arg Arg Gln Gly Leu Lys Arg Leu Ser Val Glu Ile
65                  70                  75                  80  
Asp Thr Leu Arg Arg Arg Pro Lys Ile Gly Ser Ser Ser Gln Arg Pro
                85                  90                  95      
Ile Lys Leu Lys Glu Ala Ser Tyr Ser Asn Asp Asn Gln Ile Ile Leu
            100                 105                 110         
Gln Ser Pro Ser Ser Asn Gly Xaa Lys Lys Asp Ile His Lys Cys Val
        115                 120                 125             
Asp Phe Lys Pro Lys Asp Ile Lys Leu Thr Asn Ala Gly Ser Lys Leu
    130                 135                 140                 
Asp His Gly Ile Lys Ser Leu Ser Ser Pro Lys Ile Ala Ser Asp Val
145                 150                 155                 160 
Lys Pro Lys Ala Glu Gly Gln Ala Ser Glu Asn Lys Trp Ser His Leu
                165                 170                 175     
Leu Val Gln Arg Glu Lys Met Lys Glu Leu Lys Lys Gly Arg Asn Ser
            180                 185                 190         
Lys Phe Arg Asp Asn Ser Glu Lys Cys Val Leu Glu Lys Trp Lys Arg
        195                 200                 205             
Asn Gln Phe Ser Gln Asp Tyr Asn Ser Asn Lys Ile Ile Lys Glu Pro
    210                 215                 220                 
Leu Gly Ser Arg Arg Gln Lys Ile Ser Phe Lys Ile Pro Ile Lys Ser
225                 230                 235                 240 
Arg Asp Thr Leu Gln Lys Leu Val Glu Glu Asn Val Phe Asn Ile Asp
                245                 250                 255     
Ser Asn Asn Ser Lys Thr Lys Gln Glu Glu Arg Glu Tyr Leu Glu Ser
            260                 265                 270         
Ser Gln Val Ser Leu Asn Val Thr Arg Gln Lys Thr Glu His Leu Leu
        275                 280                 285             
Ser Asp Phe Thr Tyr Lys Arg Thr Val His Glu Trp Lys Arg Lys His
    290                 295                 300                 
His Tyr Asp His Gln Glu Ser Asn Asp Ser His Ser Arg Glu Asn Leu
305                 310                 315                 320 
Thr Gln Ser Phe Glu Ala Pro Cys Cys Ser Val Ser Ser Glu Ser Ile
                325                 330                 335     
Gln Asp Ala Asp Gln Glu Met Gln Ile Val Glu Glu Leu His Ala Ala
            340                 345                 350         
Arg Val Gly Lys Ser Val Asp Leu Pro Gly Glu Leu Met Ser Met Glu
        355                 360                 365             
Ile Asp Leu Glu Asp Asp Val His Ser Ser Ser Ala Asn Asn Thr Ser
    370                 375                 380                 
Asp Arg Lys Leu Leu Ile Val Ile Asp Thr Asn Ile Leu Met Asn His
385                 390                 395                 400 
Leu Lys Phe Val Arg Ile Leu Lys Thr Thr Glu Val Pro Gly Phe Asp
                405                 410                 415     
Lys Leu Val Leu Ile Ile Pro Trp Val Val Met Gln Glu Val Asp Arg
            420                 425                 430         
Met Lys Glu Gly Lys Leu Leu Lys Arg Ala Gln His Lys Ala Ile Pro
        435                 440                 445             
Ala Val His Phe Ile Asn Asp Ser Leu Lys Asn Gln Asp Arg Lys Leu
    450                 455                 460                 
Trp Gly Gln Ser Ile Gln Leu Ala Ser Gln Lys His Tyr Gly Leu Ser
465                 470                 475                 480 
Asp Glu Asn Asn Asp Asp Arg Val Leu Lys Cys Cys Leu Gln His Gln
                485                 490                 495     
Glu Leu Phe Pro Cys Ser Phe Val Ile Leu Cys Thr Asp Asp Arg Asn
            500                 505                 510         
Leu Arg Asn Lys Gly Leu Ile Ser Gly Val Lys Ser Leu Ser Lys Glu
        515                 520                 525             
Glu Leu Ser Ala Glu Leu Leu His Leu Ser Leu Asn Thr Asp Val Cys
    530                 535                 540                 
His Gln Pro Cys Ile Pro Lys Gln Gln Leu Lys Ala Glu Thr Thr Pro
545                 550                 555                 560 
Leu Lys Glu Ser Tyr Lys Glu Glu Ser Thr Asn Ser Gly Leu Ser Ile
                565                 570                 575     
Leu Leu Glu Ser Ile Val Ser Asp Leu Glu Lys Ser Leu Gly Thr Gly
            580                 585                 590         
Leu Ser Ser Ile Leu Glu Thr Glu Met Lys Ile Ala Phe Gly Asn Leu
        595                 600                 605             
Trp Met Glu Ile Leu Tyr Leu Lys Pro Pro Trp Thr Leu Leu His Leu
    610                 615                 620                 
Leu Gln Cys Phe Lys Lys His Trp Leu Ala Val Phe Gly Leu Val Met
625                 630                 635                 640 
Glu Lys Asn Leu Leu Leu Thr Ile Glu Ser Leu Tyr Lys Asn Leu Arg
                645                 650                 655     
Lys Ala Asn Lys Ala Val Asp Phe Thr Thr Val Lys Phe Leu Leu Gln
            660                 665                 670         
Asp Ser Arg Ser Leu Leu His Ala Phe Ser Thr Arg Ser Asn Tyr Asp
        675                 680                 685             
Gly Ile Leu Pro Gln Thr Phe Ala Gln Val Asn Asn Leu Leu Gln Thr
    690                 695                 700                 
Phe Ala Glu Val Lys Thr Lys Leu Lys Pro Asn Ser Ser Glu Asn Thr
705                 710                 715                 720 
Val Thr Lys Lys Gln Glu Gly Thr Ser Leu Lys Asn Ser His Asn Gln
                725                 730                 735     
Glu Ile Thr Val Phe Ser Ser Ser His Leu Pro Gln Pro Ser Arg His
            740                 745                 750         
Gln Glu Ile Trp Ser Ile Leu Glu Ser Val Trp Ile Thr Ile Tyr Gln
        755                 760                 765             
Asn Ser Thr Asp Val Phe Gln Arg Leu Gly Ser Asn Ser Ala Leu Thr
    770                 775                 780                 
Thr Ser Asn Ile Ala Ser Phe Glu Glu Ala Phe Ile Cys Leu Gln Lys
785                 790                 795                 800 
Leu Met Ala Ala Val Arg Asp Ile Leu Glu Gly Ile Gln Arg Ile Leu
                805                 810                 815     
Ala Pro Asn Ser Asx Tyr Gln Asp Val Glu Thr Leu Tyr Asn Phe Leu
            820                 825                 830         
Ile Lys Tyr Glu Val Asn Lys Asn Val Lys Phe Thr Ala Gln Glu Ile
        835                 840                 845             
Tyr Asp Cys Val Ser Gln Thr Glu Tyr Arg Glu Lys Leu Thr Ile Gly
    850                 855                 860                 
Cys Arg Gln Leu Val Glu Met Glu Tyr Thr Met Gln Gln Cys Asn Ala
865                 870                 875                 880 
Ser Val Tyr Met Glu Ala Lys Asn Arg Gly Trp Cys Glu Asp Met Leu
                885                 890                 895     
Asn Tyr Arg Ile
            900 


<210> 1340
<211> 53
<212> PRT
<213> Homo sapiens

<400> 1340
Gln Val Val Leu Glu Glu Gly Thr Ile Ala Phe Lys Asn Trp Val Lys
 1               5                  10                  15      
Thr Gly Thr Glu Val Tyr Arg Gln Phe Trp Ile Phe Asp Val Gln Asn
            20                  25                  30          
Pro Gln Glu Val Met Met Asn Ser Ser Asn Ile Gln Val Lys Gln Arg
        35                  40                  45              
Gly Pro Tyr Thr Tyr
    50              


<210> 1341
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1341
Tyr Asn Asn Thr Ala Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp
 1               5                  10                  15      
Asn Ile Ser Lys Val Ala Ile Ile Asp Thr Tyr Lys Gly Lys
            20                  25                  30  


<210> 1342
<211> 1102
<212> PRT
<213> Homo sapiens

<400> 1342
Met Glu Leu Glu Asn Tyr Lys Gln Pro Val Val Leu Arg Glu Asp Asn
 1               5                  10                  15      
Cys Arg Arg Arg Arg Arg Met Lys Pro Arg Ser Ala Ala Ala Ser Leu
            20                  25                  30          
Ser Ser Met Glu Leu Ile Pro Ile Glu Phe Val Leu Pro Thr Ser Gln
        35                  40                  45              
Arg Lys Cys Lys Ser Pro Glu Thr Ala Leu Leu His Val Ala Gly His
    50                  55                  60                  
Gly Asn Val Glu Gln Met Lys Ala Gln Val Trp Leu Arg Ala Leu Glu
65                  70                  75                  80  
Thr Ser Val Ala Ala Asp Phe Tyr His Arg Leu Gly Pro His His Phe
                85                  90                  95      
Leu Leu Leu Tyr Gln Lys Lys Gly Gln Trp Tyr Glu Ile Tyr Asp Lys
            100                 105                 110         
Tyr Gln Val Val Gln Thr Leu Asp Cys Leu Arg Tyr Trp Lys Ala Thr
        115                 120                 125             
His Arg Ser Pro Gly Gln Ile His Leu Val Gln Arg His Pro Pro Ser
    130                 135                 140                 
Glu Glu Ser Gln Ala Phe Gln Arg Gln Leu Thr Ala Leu Ile Gly Tyr
145                 150                 155                 160 
Asp Val Thr Asp Val Ser Asn Val His Asp Asp Glu Leu Glu Phe Thr
                165                 170                 175     
Arg Arg Gly Leu Val Thr Pro Arg Met Ala Glu Val Ala Ser Arg Asp
            180                 185                 190         
Pro Lys Leu Tyr Ala Met His Pro Trp Val Thr Ser Lys Pro Leu Pro
        195                 200                 205             
Glu Tyr Leu Trp Lys Lys Ile Ala Asn Asn Cys Ile Phe Ile Val Ile
    210                 215                 220                 
His Arg Ser Thr Thr Ser Gln Thr Ile Lys Val Ser Pro Asp Asp Thr
225                 230                 235                 240 
Pro Gly Ala Ile Leu Gln Ser Phe Phe Thr Lys Met Ala Lys Lys Lys
                245                 250                 255     
Ser Leu Met Asp Ile Pro Glu Ser Gln Ser Glu Gln Asp Phe Val Leu
            260                 265                 270         
Arg Val Cys Gly Arg Asp Glu Tyr Leu Val Gly Glu Thr Pro Ile Lys
        275                 280                 285             
Asn Phe Gln Trp Val Arg His Cys Leu Lys Asn Gly Glu Glu Ile His
    290                 295                 300                 
Val Val Leu Asp Thr Pro Pro Asp Pro Ala Leu Asp Glu Val Arg Lys
305                 310                 315                 320 
Glu Glu Trp Pro Leu Val Asp Asp Cys Thr Gly Val Thr Gly Tyr His
                325                 330                 335     
Glu Gln Leu Thr Ile His Gly Lys Asp His Glu Ser Val Phe Thr Val
            340                 345                 350         
Ser Leu Trp Asp Cys Asp Arg Lys Phe Arg Val Lys Ile Arg Gly Ile
        355                 360                 365             
Asp Ile Pro Val Leu Pro Arg Asn Thr Asp Leu Thr Val Phe Val Glu
    370                 375                 380                 
Ala Asn Ile Gln His Gly Gln Gln Val Leu Cys Gln Arg Arg Thr Ser
385                 390                 395                 400 
Pro Lys Pro Phe Thr Glu Glu Val Leu Trp Asn Val Trp Leu Glu Phe
                405                 410                 415     
Ser Ile Lys Ile Lys Asp Leu Pro Lys Gly Ala Leu Leu Asn Leu Gln
            420                 425                 430         
Ile Tyr Cys Gly Lys Ala Pro Ala Leu Ser Ser Lys Ala Ser Ala Glu
        435                 440                 445             
Ser Pro Ser Ser Glu Ser Lys Gly Lys Val Arg Leu Leu Tyr Tyr Val
    450                 455                 460                 
Asn Leu Leu Leu Ile Asp His Arg Phe Leu Leu Arg Arg Gly Glu Tyr
465                 470                 475                 480 
Val Leu His Met Trp Gln Ile Ser Gly Lys Gly Glu Asp Gln Gly Ser
                485                 490                 495     
Phe Asn Ala Asp Lys Leu Thr Ser Ala Thr Asn Pro Asp Lys Glu Asn
            500                 505                 510         
Ser Met Ser Ile Ser Ile Leu Leu Asp Asn Tyr Cys His Pro Ile Ala
        515                 520                 525             
Leu Pro Lys His Gln Pro Thr Pro Asp Pro Glu Gly Asp Arg Val Arg
    530                 535                 540                 
Ala Glu Met Pro Asn Gln Leu Arg Lys Gln Leu Glu Ala Ile Ile Ala
545                 550                 555                 560 
Thr Asp Pro Leu Asn Pro Leu Thr Ala Glu Asp Lys Glu Leu Leu Trp
                565                 570                 575     
His Phe Arg Tyr Glu Ser Leu Lys His Pro Lys Ala Tyr Pro Lys Leu
            580                 585                 590         
Phe Ser Ser Val Lys Trp Gly Gln Gln Glu Ile Val Ala Lys Thr Tyr
        595                 600                 605             
Gln Leu Leu Ala Arg Arg Glu Val Trp Asp Gln Ser Ala Leu Asp Val
    610                 615                 620                 
Gly Leu Thr Met Gln Leu Leu Asp Cys Asn Phe Ser Asp Glu Asn Val
625                 630                 635                 640 
Arg Ala Ile Ala Val Gln Lys Leu Glu Ser Leu Glu Asp Asp Asp Val
                645                 650                 655     
Leu His Tyr Leu Leu Gln Leu Val Gln Ala Val Lys Phe Glu Pro Tyr
            660                 665                 670         
His Asp Ser Ala Leu Ala Arg Phe Leu Leu Lys Arg Gly Leu Arg Asn
        675                 680                 685             
Lys Arg Ile Gly His Phe Leu Phe Trp Phe Leu Arg Ser Glu Ile Ala
    690                 695                 700                 
Gln Ser Arg His Tyr Gln Gln Arg Phe Ala Val Ile Leu Glu Ala Tyr
705                 710                 715                 720 
Leu Arg Gly Cys Gly Thr Ala Met Leu His Asp Phe Thr Gln Gln Val
                725                 730                 735     
Gln Val Ile Glu Met Leu Gln Lys Val Thr Leu Asp Ile Lys Ser Leu
            740                 745                 750         
Ser Ala Glu Lys Tyr Asp Val Ser Ser Gln Val Ile Ser Gln Leu Lys
        755                 760                 765             
Gln Lys Leu Glu Asn Leu Gln Asn Ser Gln Leu Pro Glu Ser Phe Arg
    770                 775                 780                 
Val Pro Tyr Asp Pro Gly Leu Lys Ala Gly Ala Leu Ala Ile Glu Lys
785                 790                 795                 800 
Cys Lys Val Met Ala Ser Lys Lys Lys Pro Leu Trp Leu Glu Phe Lys
                805                 810                 815     
Cys Ala Asp Pro Thr Ala Leu Ser Asn Glu Thr Ile Gly Ile Ile Phe
            820                 825                 830         
Lys His Gly Asp Asp Leu Arg Gln Asp Met Leu Ile Leu Gln Ile Leu
        835                 840                 845             
Arg Ile Met Glu Ser Ile Trp Glu Thr Glu Ser Leu Asp Leu Cys Leu
    850                 855                 860                 
Leu Pro Tyr Gly Cys Ile Ser Thr Gly Asp Lys Ile Gly Met Ile Glu
865                 870                 875                 880 
Ile Val Lys Asp Ala Thr Thr Ile Ala Lys Ile Gln Gln Ser Thr Val
                885                 890                 895     
Gly Asn Thr Gly Ala Phe Lys Asp Glu Val Leu Asn His Trp Leu Lys
            900                 905                 910         
Glu Lys Ser Pro Thr Glu Glu Lys Phe Gln Ala Ala Val Glu Arg Phe
        915                 920                 925             
Val Tyr Ser Cys Ala Gly Tyr Cys Val Ala Thr Phe Val Leu Gly Ile
    930                 935                 940                 
Gly Asp Arg His Asn Asp Asn Ile Met Ile Thr Glu Thr Gly Asn Leu
945                 950                 955                 960 
Phe His Ile Asp Phe Gly His Ile Leu Gly Asn Tyr Lys Ser Phe Leu
                965                 970                 975     
Gly Ile Asn Lys Glu Arg Val Pro Phe Val Leu Thr Pro Asp Phe Leu
            980                 985                 990         
Phe Val Met Gly Thr Ser Gly Lys Lys Thr Ser Pro His Phe Gln Lys
        995                 1000                1005            
Phe Gln Asp Ile Cys Val Lys Ala Tyr Leu Ala Leu Arg His His Thr
    1010                1015                1020                
Asn Leu Leu Ile Ile Leu Phe Ser Met Met Leu Met Thr Gly Met Pro
1025                1030                1035                1040
Gln Leu Thr Ser Lys Glu Asp Ile Glu Tyr Ile Arg Asp Ala Leu Thr
                1045                1050                1055    
Val Gly Lys Asn Glu Glu Asp Ala Lys Lys Tyr Phe Leu Asp Gln Ile
            1060                1065                1070        
Glu Val Cys Arg Asp Lys Gly Trp Thr Val Gln Phe Asn Trp Phe Leu
        1075                1080                1085            
His Leu Val Leu Gly Ile Lys Gln Gly Glu Lys His Ser Ala
    1090                1095                1100        


<210> 1343
<211> 267
<212> PRT
<213> Homo sapiens

<400> 1343
Met Lys Arg Leu Val Cys Val Leu Leu Val Cys Ser Ser Ala Val Ala
 1               5                  10                  15      
Gln Leu His Lys Asp Pro Thr Leu Asp His His Trp His Leu Trp Lys
            20                  25                  30          
Lys Thr Tyr Gly Lys Gln Tyr Lys Glu Lys Asn Glu Glu Ala Val Arg
        35                  40                  45              
Arg Leu Ile Trp Glu Lys Asn Leu Lys Phe Val Met Leu His Asn Leu
    50                  55                  60                  
Glu His Ser Met Gly Met His Ser Tyr Asp Leu Gly Met Asn His Leu
65                  70                  75                  80  
Gly Asp Met Thr Ser Glu Glu Val Met Ser Leu Thr Ser Ser Leu Arg
                85                  90                  95      
Val Pro Ser Gln Trp Gln Arg Asn Ile Thr Tyr Lys Ser Asn Pro Asn
            100                 105                 110         
Arg Ile Leu Pro Asp Ser Val Asp Trp Arg Glu Lys Gly Cys Val Thr
        115                 120                 125             
Glu Val Lys Tyr Gln Gly Ser Cys Gly Ala Cys Trp Ala Phe Ser Ala
    130                 135                 140                 
Val Gly Ala Leu Glu Ala Gln Leu Lys Leu Lys Thr Gly Lys Leu Val
145                 150                 155                 160 
Thr Leu Ser Ala Gln Asn Leu Val Asp Cys Ser Thr Glu Lys Tyr Gly
                165                 170                 175     
Asn Lys Gly Cys Asn Gly Gly Phe Met Thr Thr Ala Phe Gln Tyr Ile
            180                 185                 190         
Ile Asp Asn Lys Gly Ile Asp Ser Asp Ala Ser Tyr Pro Tyr Lys Ala
        195                 200                 205             
Met Asp Gln Lys Cys Gln Tyr Asp Ser Lys Tyr Arg Ala Ala Thr Cys
    210                 215                 220                 
Ser Lys Tyr Thr Glu Leu Pro Tyr Gly Arg Glu Asp Val Leu Lys Glu
225                 230                 235                 240 
Ala Val Ala Asn Lys Gly Pro Val Ser Val Gly Val Asp Ala Arg His
                245                 250                 255     
Pro Ser Phe Phe Leu Tyr Arg Ser Gly Val Tyr
            260                 265         


<210> 1344
<211> 201
<212> PRT
<213> Homo sapiens

<400> 1344
Met Gly Ala Gly Ala Glu Thr Gly Arg Gly Gln Arg Ala Ala Ala Pro
 1               5                  10                  15      
Glu Arg Arg His Gly Arg Leu Leu Trp Leu Leu Arg Gly Leu Thr Leu
            20                  25                  30          
Gly Thr Ala Pro Arg Arg Ala Val Arg Gly Gln Ala Gly Gly Gly Gly
        35                  40                  45              
Pro Gly Thr Ala Gly Ile Val Gly Glu Ala Gly Ser Leu Ala Thr Cys
    50                  55                  60                  
Glu Leu Pro Leu Ala Lys Ser Glu Trp Gln Lys Lys Leu Thr Pro Glu
65                  70                  75                  80  
Gln Phe Tyr Val Thr Arg Glu Lys Gly Thr Glu Pro Pro Phe Ser Gly
                85                  90                  95      
Ile Tyr Leu Asn Asn Lys Glu Ala Gly Met Tyr His Cys Val Cys Cys
            100                 105                 110         
Asp Ser Pro Leu Phe Ser Ser Glu Lys Lys Tyr Cys Ser Gly Thr Gly
        115                 120                 125             
Trp Pro Ser Phe Ser Glu Ala His Gly Thr Ser Gly Ser Asp Glu Ser
    130                 135                 140                 
His Thr Gly Ile Leu Arg Arg Leu Asp Thr Ser Leu Gly Ser Ala Arg
145                 150                 155                 160 
Thr Glu Val Val Cys Lys Gln Cys Glu Ala His Leu Gly His Val Phe
                165                 170                 175     
Pro Asp Gly Pro Gly Pro Asn Gly Gln Arg Phe Cys Ile Asn Ser Val
            180                 185                 190         
Ala Leu Lys Phe Lys Pro Arg Lys His
        195                 200     


<210> 1345
<211> 898
<212> PRT
<213> Homo sapiens

<400> 1345
Met Phe Ser Gln Gln Gln Gln Gln Gln Leu Gln Gln Gln Gln Gln Gln
 1               5                  10                  15      
Leu Gln Gln Leu Gln Gln Gln Gln Leu Gln Gln Gln Gln Leu Gln Gln
            20                  25                  30          
Gln Gln Leu Leu Gln Leu Gln Gln Leu Leu Gln Gln Ser Pro Pro Gln
        35                  40                  45              
Ala Pro Leu Pro Met Ala Val Ser Arg Gly Leu Pro Pro Gln Gln Pro
    50                  55                  60                  
Gln Gln Pro Leu Leu Asn Leu Gln Gly Thr Asn Ser Ala Ser Leu Leu
65                  70                  75                  80  
Asn Gly Ser Met Leu Gln Arg Ala Leu Leu Leu Gln Gln Leu Gln Gly
                85                  90                  95      
Leu Asp Gln Phe Ala Met Pro Pro Ala Thr Tyr Asp Thr Ala Gly Leu
            100                 105                 110         
Thr Met Pro Thr Ala Thr Leu Gly Asn Leu Arg Gly Tyr Gly Met Ala
        115                 120                 125             
Ser Pro Gly Leu Ala Ala Pro Ser Leu Thr Pro Pro Gln Leu Ala Thr
    130                 135                 140                 
Pro Asn Leu Gln Gln Phe Phe Pro Gln Ala Thr Arg Gln Ser Leu Leu
145                 150                 155                 160 
Gly Pro Pro Pro Val Gly Val Pro Met Asn Pro Ser Gln Phe Asn Leu
                165                 170                 175     
Ser Gly Arg Asn Pro Gln Lys Gln Ala Arg Thr Ser Ser Ser Thr Thr
            180                 185                 190         
Pro Asn Arg Lys Asp Ser Ser Ser Gln Thr Met Pro Val Glu Asp Lys
        195                 200                 205             
Ser Asp Pro Pro Glu Gly Ser Glu Glu Ala Ala Glu Pro Arg Met Asp
    210                 215                 220                 
Thr Pro Glu Asp Gln Asp Leu Leu Pro Cys Pro Glu Asp Ile Ala Lys
225                 230                 235                 240 
Glu Lys Arg Thr Pro Ala Pro Glu Pro Glu Pro Cys Glu Ala Ser Glu
                245                 250                 255     
Leu Pro Ala Lys Arg Leu Arg Ser Ser Glu Glu Pro Thr Glu Lys Glu
            260                 265                 270         
Pro Pro Gly Gln Leu Gln Val Lys Ala Gln Pro Gln Ala Arg Met Thr
        275                 280                 285             
Val Pro Lys Gln Thr Gln Thr Pro Asp Leu Leu Pro Glu Ala Leu Glu
    290                 295                 300                 
Ala Gln Val Leu Pro Arg Phe Gln Pro Arg Val Leu Gln Val Gln Ala
305                 310                 315                 320 
Gln Val Gln Ser Gln Thr Gln Pro Arg Ile Pro Ser Thr Asp Thr Gln
                325                 330                 335     
Val Gln Pro Lys Leu Gln Lys Gln Ala Gln Thr Gln Thr Ser Pro Glu
            340                 345                 350         
His Leu Val Leu Gln Gln Lys Gln Val Gln Pro Gln Leu Gln Gln Glu
        355                 360                 365             
Ala Glu Pro Gln Lys Gln Val Gln Pro Gln Val Gln Pro Gln Ala His
    370                 375                 380                 
Ser Gln Gly Pro Arg Gln Val Gln Leu Gln Gln Glu Ala Glu Pro Leu
385                 390                 395                 400 
Lys Gln Val Gln Pro Gln Val Gln Pro Gln Ala His Ser Gln Pro Pro
                405                 410                 415     
Arg Gln Val Gln Leu Gln Leu Gln Lys Gln Val Gln Thr Gln Thr Tyr
            420                 425                 430         
Pro Gln Val His Thr Gln Ala Gln Pro Ser Val Gln Pro Gln Glu His
        435                 440                 445             
Pro Pro Ala Gln Val Ser Val Gln Pro Pro Glu Gln Thr His Glu Gln
    450                 455                 460                 
Pro His Thr Gln Pro Gln Val Ser Leu Leu Ala Pro Glu Gln Thr Pro
465                 470                 475                 480 
Val Val Val His Val Cys Gly Leu Glu Met Pro Pro Asp Ala Val Glu
                485                 490                 495     
Ala Gly Gly Gly Met Glu Lys Thr Leu Pro Glu Pro Val Gly Thr Gln
            500                 505                 510         
Val Ser Met Glu Glu Ile Gln Asn Glu Ser Ala Cys Gly Leu Asp Val
        515                 520                 525             
Gly Glu Cys Glu Asn Arg Ala Arg Glu Met Pro Gly Val Trp Gly Ala
    530                 535                 540                 
Gly Gly Ser Leu Lys Val Thr Ile Leu Gln Gly Ser Asp Ser Arg Ala
545                 550                 555                 560 
Phe Ser Thr Val Pro Leu Thr Pro Val Pro Arg Pro Ser Asp Ser Val
                565                 570                 575     
Ser Ser Thr Pro Ala Ala Thr Ser Thr Pro Ser Lys Gln Ala Leu Gln
            580                 585                 590         
Phe Phe Cys Tyr Ile Cys Lys Ala Ser Cys Ser Ser Gln Gln Glu Phe
        595                 600                 605             
Gln Asp His Met Ser Glu Pro Gln His Gln Gln Arg Leu Gly Glu Ile
    610                 615                 620                 
Gln His Met Ser Gln Ala Cys Leu Leu Ser Leu Leu Pro Val Pro Arg
625                 630                 635                 640 
Asp Val Leu Glu Thr Glu Asp Glu Glu Pro Pro Pro Arg Arg Trp Cys
                645                 650                 655     
Asn Thr Cys Gln Leu Tyr Tyr Met Gly Asp Leu Ile Gln His Arg Arg
            660                 665                 670         
Thr Gln Asp His Lys Ile Ala Lys Gln Ser Leu Arg Pro Phe Cys Thr
        675                 680                 685             
Val Cys Asn Arg Tyr Phe Lys Thr Pro Arg Lys Phe Val Glu His Val
    690                 695                 700                 
Lys Ser Gln Gly His Lys Asp Lys Ala Lys Glu Leu Lys Ser Leu Glu
705                 710                 715                 720 
Lys Glu Ile Ala Gly Gln Asp Glu Asp His Phe Ile Thr Val Asp Ala
                725                 730                 735     
Val Gly Cys Phe Glu Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Asp
            740                 745                 750         
Glu Glu Glu Ile Glu Val Glu Glu Glu Leu Cys Lys Gln Val Arg Ser
        755                 760                 765             
Arg Asp Ile Ser Arg Glu Glu Trp Lys Gly Ser Glu Thr Tyr Ser Pro
    770                 775                 780                 
Asn Thr Ala Tyr Gly Val Asp Phe Leu Val Pro Val Met Gly Tyr Ile
785                 790                 795                 800 
Cys Arg Ile Cys His Lys Phe Tyr His Ser Asn Ser Gly Ala Gln Leu
                805                 810                 815     
Ser His Cys Lys Ser Leu Gly His Phe Glu Asn Leu Gln Lys Tyr Lys
            820                 825                 830         
Ala Ala Lys Asn Pro Ser Pro Thr Thr Arg Pro Val Ser Arg Arg Cys
        835                 840                 845             
Ala Ile Asn Ala Arg Asn Ala Leu Thr Ala Leu Phe Thr Ser Ser Gly
    850                 855                 860                 
Arg Pro Pro Ser Gln Pro Asn Thr Gln Asp Lys Thr Pro Ser Lys Val
865                 870                 875                 880 
Thr Ala Arg Pro Ser Gln Pro Pro Leu Pro Arg Arg Ser Thr Arg Leu
                885                 890                 895     
Lys Thr
        


<210> 1346
<211> 469
<212> PRT
<213> Homo sapiens

<400> 1346
Met Gly Thr Val His Ala Arg Ser Leu Glu Pro Leu Pro Ser Ser Gly
 1               5                  10                  15      
Pro Asp Phe Gly Gly Leu Gly Glu Glu Ala Glu Phe Val Glu Val Glu
            20                  25                  30          
Pro Glu Ala Lys Gln Glu Ile Leu Glu Asn Lys Asp Val Val Val Gln
        35                  40                  45              
His Val His Phe Asp Gly Leu Gly Arg Thr Lys Asp Asp Ile Ile Ile
    50                  55                  60                  
Cys Glu Ile Gly Asp Val Phe Lys Ala Lys Asn Leu Ile Glu Val Met
65                  70                  75                  80  
Arg Lys Ser His Glu Ala Arg Glu Lys Leu Leu Arg Leu Gly Ile Phe
                85                  90                  95      
Arg Gln Val Asp Val Leu Ile Asp Thr Cys Gln Gly Asp Asp Ala Leu
            100                 105                 110         
Pro Asn Gly Leu Asp Val Thr Phe Glu Val Thr Glu Leu Arg Arg Leu
        115                 120                 125             
Thr Gly Ser Tyr Asn Thr Met Val Gly Asn Asn Glu Gly Ser Met Val
    130                 135                 140                 
Leu Gly Leu Lys Leu Pro Asn Leu Leu Gly Arg Ala Glu Lys Val Thr
145                 150                 155                 160 
Phe Gln Phe Ser Tyr Gly Thr Lys Glu Thr Ser Tyr Gly Leu Ser Phe
                165                 170                 175     
Phe Lys Pro Arg Pro Gly Asn Phe Glu Arg Asn Phe Ser Val Asn Leu
            180                 185                 190         
Tyr Lys Val Thr Gly Gln Phe Pro Trp Ser Ser Leu Arg Glu Thr Asp
        195                 200                 205             
Arg Gly Met Ser Ala Glu Tyr Ser Phe Pro Ile Trp Lys Thr Ser His
    210                 215                 220                 
Thr Val Lys Trp Glu Gly Val Trp Arg Glu Leu Gly Cys Leu Ser Arg
225                 230                 235                 240 
Thr Ala Ser Phe Ala Val Arg Lys Glu Ser Gly His Ser Leu Lys Ser
                245                 250                 255     
Ser Leu Ser His Ala Met Val Ile Asp Ser Arg Asn Ser Ser Ile Leu
            260                 265                 270         
Pro Arg Arg Gly Ala Leu Leu Lys Val Asn Gln Glu Leu Ala Gly Tyr
        275                 280                 285             
Thr Gly Gly Asp Val Ser Phe Ile Lys Glu Asp Phe Glu Leu Gln Leu
    290                 295                 300                 
Asn Lys Gln Leu Ile Phe Asp Ser Val Phe Ser Ala Ser Phe Trp Gly
305                 310                 315                 320 
Gly Met Leu Val Pro Ile Gly Asp Lys Pro Ser Ser Ile Ala Asp Arg
                325                 330                 335     
Phe Tyr Leu Gly Gly Pro Thr Ser Ile Arg Gly Phe Ser Met His Ser
            340                 345                 350         
Ile Gly Pro Gln Ser Glu Gly Asp Tyr Leu Gly Gly Glu Ala Tyr Trp
        355                 360                 365             
Ala Gly Gly Leu His Leu Tyr Thr Pro Leu Pro Phe Arg Pro Gly Gln
    370                 375                 380                 
Gly Gly Phe Gly Glu Leu Phe Arg Thr His Phe Phe Leu Asn Ala Gly
385                 390                 395                 400 
Asn Leu Cys Asn Leu Asn Tyr Gly Glu Gly Pro Lys Ala His Ile Arg
                405                 410                 415     
Lys Leu Ala Glu Cys Ile Arg Trp Ser Tyr Gly Ala Gly Ile Val Leu
            420                 425                 430         
Arg Leu Gly Asn Ile Ala Arg Leu Glu Leu Asn Tyr Cys Val Pro Met
        435                 440                 445             
Gly Val Gln Thr Gly Asp Arg Ile Cys Asp Gly Val Gln Phe Gly Ala
    450                 455                 460                 
Gly Ile Arg Phe Leu
465                 


<210> 1347
<211> 501
<212> PRT
<213> Homo sapiens

<400> 1347
Met Ala Ala Ser Trp Arg Leu Gly Cys Asp Pro Arg Leu Leu Arg Tyr
 1               5                  10                  15      
Leu Val Gly Phe Pro Gly Arg Arg Ser Val Gly Leu Val Lys Gly Ala
            20                  25                  30          
Leu Gly Trp Ser Val Ser Arg Gly Ala Asn Trp Arg Trp Phe His Ser
        35                  40                  45              
Thr Gln Trp Leu Arg Gly Asp Pro Ile Lys Ile Leu Met Pro Ser Leu
    50                  55                  60                  
Ser Pro Thr Met Glu Glu Gly Asn Ile Val Lys Trp Leu Lys Lys Glu
65                  70                  75                  80  
Gly Glu Ala Val Ser Ala Gly Asp Ala Leu Cys Glu Ile Glu Thr Asp
                85                  90                  95      
Lys Ala Val Val Thr Leu Asp Ala Ser Asp Asp Gly Ile Leu Ala Lys
            100                 105                 110         
Ile Val Val Glu Glu Gly Ser Lys Asn Ile Arg Leu Gly Ser Leu Ile
        115                 120                 125             
Gly Leu Ile Val Glu Glu Gly Glu Asp Trp Lys His Val Glu Ile Pro
    130                 135                 140                 
Lys Asp Val Gly Pro Pro Pro Pro Val Ser Lys Pro Ser Glu Pro Arg
145                 150                 155                 160 
Pro Ser Pro Glu Pro Gln Ile Ser Ile Pro Val Lys Lys Glu His Ile
                165                 170                 175     
Pro Gly Thr Leu Arg Phe Arg Leu Ser Pro Ala Ala Arg Asn Ile Leu
            180                 185                 190         
Glu Lys His Ser Leu Asp Ala Ser Gln Gly Thr Ala Thr Gly Pro Arg
        195                 200                 205             
Gly Ile Phe Thr Lys Glu Asp Ala Leu Lys Leu Val Gln Leu Lys Gln
    210                 215                 220                 
Thr Gly Lys Ile Thr Glu Ser Arg Pro Thr Pro Ala Pro Thr Ala Thr
225                 230                 235                 240 
Pro Thr Ala Pro Ser Pro Leu Gln Ala Thr Ala Gly Pro Ser Tyr Pro
                245                 250                 255     
Arg Pro Val Ile Pro Pro Val Ser Thr Pro Gly Gln Pro Asn Ala Val
            260                 265                 270         
Gly Thr Phe Thr Glu Ile Pro Ala Ser Asn Ile Arg Arg Val Ile Ala
        275                 280                 285             
Lys Arg Leu Thr Glu Ser Lys Ser Thr Val Pro His Ala Tyr Ala Thr
    290                 295                 300                 
Ala Asp Cys Asp Leu Gly Ala Val Leu Lys Val Arg Gln Asp Leu Val
305                 310                 315                 320 
Lys Asp Asp Ile Lys Val Ser Val Asn Asp Phe Ile Ile Lys Ala Ala
                325                 330                 335     
Ala Val Thr Leu Lys Gln Met Pro Asp Val Asn Val Ser Trp Asp Gly
            340                 345                 350         
Glu Gly Pro Lys Gln Leu Pro Phe Ile Asp Ile Ser Val Ala Val Ala
        355                 360                 365             
Thr Asp Lys Gly Leu Leu Thr Pro Ile Ile Lys Asp Ala Ala Ala Lys
    370                 375                 380                 
Gly Ile Gln Glu Ile Ala Asp Ser Val Lys Ala Leu Ser Lys Lys Ala
385                 390                 395                 400 
Arg Asp Gly Lys Leu Leu Pro Glu Glu Tyr Gln Gly Gly Ser Phe Ser
                405                 410                 415     
Ile Ser Asn Leu Gly Met Phe Gly Ile Asp Glu Phe Thr Ala Val Ile
            420                 425                 430         
Asn Pro Pro Gln Ala Cys Ile Leu Ala Val Gly Arg Phe Arg Pro Val
        435                 440                 445             
Leu Lys Leu Thr Glu Asp Glu Glu Gly Asn Ala Lys Leu Gln Gln Arg
    450                 455                 460                 
Gln Leu Ile Thr Val Thr Met Ser Ser Asp Ser Arg Val Val Asp Asp
465                 470                 475                 480 
Glu Leu Ala Thr Arg Phe Leu Lys Ser Phe Lys Ala Asn Leu Glu Asn
                485                 490                 495     
Pro Ile Arg Leu Ala
            500     


<210> 1348
<211> 837
<212> PRT
<213> Homo sapiens

<400> 1348
Met Ser Gln Thr Gly Ser His Pro Gly Arg Gly Leu Ala Gly Arg Trp
 1               5                  10                  15      
Leu Trp Gly Ala Gln Pro Cys Leu Leu Leu Pro Ile Val Pro Leu Ser
            20                  25                  30          
Trp Leu Val Trp Leu Leu Leu Leu Leu Leu Ala Ser Leu Leu Pro Ser
        35                  40                  45              
Ala Arg Leu Ala Ser Pro Leu Pro Arg Glu Glu Glu Ile Val Phe Pro
    50                  55                  60                  
Glu Lys Leu Asn Gly Ser Val Leu Pro Gly Ser Gly Ala Pro Ala Arg
65                  70                  75                  80  
Leu Leu Cys Arg Leu Gln Ala Phe Gly Glu Thr Leu Leu Leu Glu Leu
                85                  90                  95      
Glu Gln Asp Ser Gly Val Gln Val Glu Gly Leu Thr Val Gln Tyr Leu
            100                 105                 110         
Gly Gln Ala Pro Glu Leu Leu Gly Gly Ala Glu Pro Gly Thr Tyr Leu
        115                 120                 125             
Thr Gly Thr Ile Asn Gly Asp Pro Glu Ser Val Ala Ser Leu His Trp
    130                 135                 140                 
Asp Gly Gly Ala Leu Leu Gly Val Leu Gln Tyr Arg Gly Ala Glu Leu
145                 150                 155                 160 
His Leu Gln Pro Leu Glu Gly Gly Thr Pro Asn Ser Ala Gly Gly Pro
                165                 170                 175     
Gly Ala His Ile Leu Arg Arg Lys Ser Pro Ala Ser Gly Gln Gly Pro
            180                 185                 190         
Met Cys Asn Val Lys Ala Pro Leu Gly Ser Pro Ser Pro Arg Pro Arg
        195                 200                 205             
Arg Ala Lys Arg Phe Ala Ser Leu Ser Arg Phe Val Glu Thr Leu Val
    210                 215                 220                 
Val Ala Asp Asp Lys Met Ala Ala Phe His Gly Ala Gly Leu Lys Arg
225                 230                 235                 240 
Tyr Leu Leu Thr Val Met Ala Ala Ala Ala Lys Ala Phe Lys His Pro
                245                 250                 255     
Ser Ile Arg Asn Pro Val Ser Leu Val Val Thr Arg Leu Val Ile Leu
            260                 265                 270         
Gly Ser Gly Glu Glu Gly Pro Gln Val Gly Pro Ser Ala Ala Gln Thr
        275                 280                 285             
Leu Arg Ser Phe Cys Ala Trp Gln Arg Gly Leu Asn Thr Pro Glu Asp
    290                 295                 300                 
Ser Asp Pro Asp His Phe Asp Thr Ala Ile Leu Phe Thr Arg Gln Asp
305                 310                 315                 320 
Leu Cys Gly Val Ser Thr Cys Asp Thr Leu Gly Met Ala Asp Val Gly
                325                 330                 335     
Thr Val Cys Asp Pro Ala Arg Ser Cys Ala Ile Val Glu Asp Asp Gly
            340                 345                 350         
Leu Gln Ser Ala Phe Thr Ala Ala His Glu Leu Gly His Val Phe Asn
        355                 360                 365             
Met Leu His Asp Asn Ser Lys Pro Cys Ile Ser Leu Asn Gly Pro Leu
    370                 375                 380                 
Ser Thr Ser Arg His Val Met Ala Pro Val Met Ala His Val Asp Pro
385                 390                 395                 400 
Glu Glu Pro Trp Ser Pro Cys Ser Ala Arg Phe Ile Thr Asp Phe Leu
                405                 410                 415     
Asp Asn Gly Tyr Gly His Cys Leu Leu Asp Lys Pro Glu Ala Pro Leu
            420                 425                 430         
His Leu Pro Val Thr Phe Pro Gly Lys Asp Tyr Asp Ala Asp Arg Gln
        435                 440                 445             
Cys Gln Leu Thr Phe Gly Pro Asp Ser Arg His Cys Pro Gln Leu Pro
    450                 455                 460                 
Pro Pro Cys Ala Ala Leu Trp Cys Ser Gly His Leu Asn Gly His Ala
465                 470                 475                 480 
Met Cys Gln Thr Lys His Ser Pro Trp Ala Asp Gly Thr Pro Cys Gly
                485                 490                 495     
Pro Ala Gln Ala Cys Met Gly Gly Arg Cys Leu His Met Asp Gln Leu
            500                 505                 510         
Gln Asp Phe Asn Ile Pro Gln Ala Gly Gly Trp Gly Pro Trp Gly Pro
        515                 520                 525             
Trp Gly Asp Cys Ser Arg Thr Cys Gly Gly Gly Val Gln Phe Ser Ser
    530                 535                 540                 
Arg Asp Cys Thr Arg Pro Val Pro Arg Asn Gly Gly Lys Tyr Cys Glu
545                 550                 555                 560 
Gly Arg Arg Thr Arg Phe Arg Ser Cys Asn Thr Glu Asp Cys Pro Thr
                565                 570                 575     
Gly Ser Ala Leu Thr Phe Arg Glu Glu Gln Cys Ala Ala Tyr Asn His
            580                 585                 590         
Arg Thr Asp Leu Phe Lys Ser Phe Pro Gly Pro Met Asp Trp Val Pro
        595                 600                 605             
Arg Tyr Thr Gly Val Ala Pro Gln Asp Gln Cys Lys Leu Thr Cys Gln
    610                 615                 620                 
Ala Arg Ala Leu Gly Tyr Tyr Tyr Val Leu Glu Pro Arg Val Val Asp
625                 630                 635                 640 
Gly Thr Pro Cys Ser Pro Asp Ser Ser Ser Val Cys Val Gln Gly Arg
                645                 650                 655     
Cys Ile His Ala Gly Cys Asp Arg Ile Ile Gly Ser Lys Lys Lys Phe
            660                 665                 670         
Asp Lys Cys Met Val Cys Gly Gly Asp Gly Ser Gly Cys Ser Lys Gln
        675                 680                 685             
Ser Gly Ser Phe Arg Lys Phe Arg Tyr Gly Tyr Asn Asn Val Val Thr
    690                 695                 700                 
Ile Pro Ala Gly Ala Thr His Ile Leu Val Arg Gln Gln Gly Asn Pro
705                 710                 715                 720 
Gly His Arg Ser Ile Tyr Leu Ala Leu Lys Leu Pro Asp Gly Ser Tyr
                725                 730                 735     
Ala Leu Asn Gly Glu Tyr Thr Leu Met Pro Ser Pro Thr Asp Val Val
            740                 745                 750         
Leu Pro Gly Ala Val Ser Leu Arg Tyr Ser Gly Ala Thr Ala Ala Ser
        755                 760                 765             
Glu Thr Leu Ser Gly His Gly Pro Leu Ala Gln Pro Leu Thr Leu Gln
    770                 775                 780                 
Val Leu Val Ala Gly Asn Pro Gln Asp Thr Arg Leu Arg Tyr Ser Phe
785                 790                 795                 800 
Phe Val Pro Arg Pro Thr Pro Ser Thr Pro Arg Pro Thr Pro Gln Asp
                805                 810                 815     
Trp Leu His Arg Arg Ala Gln Ile Leu Glu Ile Leu Arg Arg Arg Pro
            820                 825                 830         
Trp Ala Gly Arg Lys
        835         


<210> 1349
<211> 2485
<212> PRT
<213> Homo sapiens

<400> 1349
Met His Val Ser Leu Ala Glu Ala Leu Glu Val Arg Gly Gly Pro Leu
 1               5                  10                  15      
Gln Glu Glu Glu Ile Trp Ala Val Leu Asn Gln Ser Ala Glu Ser Leu
            20                  25                  30          
Gln Glu Leu Phe Arg Lys Val Ser Leu Ala Asp Pro Ala Ala Leu Gly
        35                  40                  45              
Phe Ile Ile Ser Pro Trp Ser Leu Leu Leu Leu Pro Ser Gly Ser Val
    50                  55                  60                  
Ser Phe Thr Asp Glu Asn Ile Ser Asn Gln Asp Leu Arg Ala Phe Thr
65                  70                  75                  80  
Ala Pro Glu Val Leu Gln Asn Gln Ser Leu Thr Ser Leu Ser Asp Val
                85                  90                  95      
Glu Lys Ile His Ile Tyr Ser Leu Gly Met Thr Leu Tyr Trp Gly Ala
            100                 105                 110         
Asp Tyr Glu Val Pro Gln Ser Gln Pro Ile Lys Leu Gly Asp His Leu
        115                 120                 125             
Asn Ser Ile Leu Leu Gly Met Cys Glu Asp Val Ile Tyr Ala Arg Val
    130                 135                 140                 
Ser Val Arg Thr Val Leu Asp Ala Cys Ser Ala His Ile Arg Asn Ser
145                 150                 155                 160 
Asn Cys Ala Pro Ser Phe Ser Tyr Val Lys His Leu Val Lys Leu Val
                165                 170                 175     
Leu Gly Asn Leu Ser Gly Thr Asp Gln Leu Ser Cys Asn Ser Glu Gln
            180                 185                 190         
Lys Pro Asp Arg Ser Gln Ala Ile Arg Asp Arg Leu Arg Gly Lys Gly
        195                 200                 205             
Leu Pro Thr Gly Arg Ser Ser Thr Ser Asp Val Leu Asp Ile Gln Lys
    210                 215                 220                 
Pro Pro Leu Ser His Gln Thr Phe Leu Asn Lys Gly Leu Ser Lys Ser
225                 230                 235                 240 
Met Gly Phe Leu Ser Ile Lys Asp Thr Gln Asp Glu Asn Tyr Phe Lys
                245                 250                 255     
Asp Ile Leu Ser Asp Asn Ser Gly Arg Glu Asp Ser Glu Asn Thr Phe
            260                 265                 270         
Ser Pro Tyr Gln Phe Lys Thr Ser Gly Pro Glu Lys Lys Pro Ile Pro
        275                 280                 285             
Gly Ile Asp Val Leu Ser Lys Lys Lys Ile Trp Ala Ser Ser Met Asp
    290                 295                 300                 
Leu Leu Cys Thr Ala Asp Arg Asp Phe Ser Ser Gly Glu Thr Ala Thr
305                 310                 315                 320 
Tyr Arg Arg Cys His Pro Glu Ala Val Thr Val Arg Thr Ser Thr Thr
                325                 330                 335     
Pro Arg Lys Lys Glu Ala Arg Tyr Ser Asp Gly Ser Ile Ala Leu Asp
            340                 345                 350         
Ile Phe Gly Pro Gln Lys Met Asp Pro Ile Tyr His Thr Arg Glu Leu
        355                 360                 365             
Pro Thr Ser Ser Ala Ile Ser Ser Ala Leu Asp Arg Ile Arg Glu Arg
    370                 375                 380                 
Gln Lys Lys Leu Gln Val Leu Arg Glu Ala Met Asn Val Glu Glu Pro
385                 390                 395                 400 
Val Arg Arg Tyr Lys Thr Tyr His Gly Asp Val Phe Ser Thr Ser Ser
                405                 410                 415     
Glu Ser Pro Ser Ile Ile Ser Ser Glu Ser Asp Phe Arg Gln Val Arg
            420                 425                 430         
Arg Ser Glu Ala Ser Lys Arg Phe Glu Ser Ser Ser Gly Leu Pro Gly
        435                 440                 445             
Val Asp Glu Thr Leu Ser Gln Gly Gln Ser Gln Arg Pro Ser Arg Gln
    450                 455                 460                 
Tyr Glu Thr Pro Phe Glu Gly Asn Leu Ile Asn Gln Glu Ile Met Leu
465                 470                 475                 480 
Lys Arg Gln Glu Glu Glu Leu Met Gln Leu Gln Ala Lys Met Ala Leu
                485                 490                 495     
Arg Gln Ser Arg Leu Ser Leu Tyr Pro Gly Asp Thr Ile Lys Ala Ser
            500                 505                 510         
Met Leu Asp Ile Thr Arg Asp Pro Leu Arg Glu Ile Ala Leu Glu Thr
        515                 520                 525             
Ala Met Thr Gln Arg Lys Leu Arg Asn Phe Phe Gly Pro Glu Phe Val
    530                 535                 540                 
Lys Met Thr Ile Glu Pro Phe Ile Ser Leu Asp Leu Pro Arg Ser Ile
545                 550                 555                 560 
Leu Thr Lys Lys Gly Lys Asn Glu Asp Asn Arg Arg Lys Val Asn Ile
                565                 570                 575     
Met Leu Leu Asn Gly Gln Arg Leu Glu Leu Thr Cys Asp Thr Lys Thr
            580                 585                 590         
Ile Cys Lys Asp Val Phe Asp Met Val Val Ala His Ile Gly Leu Val
        595                 600                 605             
Glu His His Leu Phe Ala Leu Ala Thr Leu Lys Asp Asn Glu Tyr Phe
    610                 615                 620                 
Phe Val Asp Pro Asp Leu Lys Leu Thr Lys Val Ala Pro Glu Gly Trp
625                 630                 635                 640 
Lys Glu Glu Pro Lys Lys Lys Thr Lys Ala Thr Val Asn Phe Thr Leu
                645                 650                 655     
Phe Phe Arg Ile Lys Phe Phe Met Asp Asp Val Ser Leu Ile Gln His
            660                 665                 670         
Thr Leu Thr Cys His Gln Tyr Tyr Leu Gln Leu Arg Lys Asp Ile Leu
        675                 680                 685             
Glu Glu Arg Met His Cys Asp Asp Glu Thr Ser Leu Leu Leu Ala Ser
    690                 695                 700                 
Leu Ala Leu Gln Ala Glu Tyr Gly Asp Tyr Gln Pro Glu Val His Gly
705                 710                 715                 720 
Val Ser Tyr Phe Arg Met Glu His Tyr Leu Pro Ala Arg Val Met Glu
                725                 730                 735     
Lys Leu Asp Leu Ser Tyr Ile Lys Glu Glu Leu Pro Lys Leu His Asn
            740                 745                 750         
Thr Tyr Val Gly Ala Ser Glu Lys Glu Thr Glu Leu Glu Phe Leu Lys
        755                 760                 765             
Val Cys Gln Arg Leu Thr Glu Tyr Gly Val His Phe His Arg Val His
    770                 775                 780                 
Pro Glu Lys Lys Ser Gln Thr Gly Ile Leu Leu Gly Val Cys Ser Lys
785                 790                 795                 800 
Gly Val Leu Val Phe Glu Val His Asn Gly Val Arg Thr Leu Val Leu
                805                 810                 815     
Arg Phe Pro Trp Arg Glu Thr Lys Lys Ile Ser Phe Ser Lys Lys Lys
            820                 825                 830         
Ile Thr Leu Gln Asn Thr Ser Asp Gly Ile Lys His Gly Phe Gln Thr
        835                 840                 845             
Asp Asn Ser Lys Ile Cys Gln Tyr Leu Leu His Leu Cys Ser Tyr Gln
    850                 855                 860                 
His Lys Phe Gln Leu Gln Met Arg Ala Arg Gln Ser Asn Gln Asp Ala
865                 870                 875                 880 
Gln Asp Ile Glu Arg Ala Ser Phe Arg Ser Leu Asn Leu Gln Ala Glu
                885                 890                 895     
Ser Val Arg Gly Phe Asn Met Gly Arg Ala Ile Ser Thr Gly Ser Leu
            900                 905                 910         
Ala Ser Ser Thr Leu Asn Lys Leu Ala Val Arg Pro Leu Ser Val Gln
        915                 920                 925             
Ala Glu Ile Leu Lys Arg Leu Ser Cys Ser Glu Leu Ser Leu Tyr Gln
    930                 935                 940                 
Pro Leu Gln Asn Ser Ser Lys Glu Lys Asn Asp Lys Ala Ser Trp Glu
945                 950                 955                 960 
Glu Lys Pro Arg Glu Met Ser Lys Ser Tyr His Asp Leu Ser Gln Ala
                965                 970                 975     
Ser Leu Tyr Pro His Arg Lys Asn Val Ile Val Asn Met Glu Pro Pro
            980                 985                 990         
Pro Gln Thr Val Ala Glu Leu Val Gly Lys Pro Ser His Gln Met Ser
        995                 1000                1005            
Arg Ser Asp Ala Glu Ser Leu Ala Gly Val Thr Lys Leu Asn Asn Ser
    1010                1015                1020                
Lys Ser Val Ala Ser Leu Asn Arg Ser Pro Glu Arg Arg Lys His Glu
1025                1030                1035                1040
Ser Asp Ser Ser Ser Ile Glu Asp Pro Gly Gln Ala Tyr Val Leu Gly
                1045                1050                1055    
Met Thr Met His Ser Ser Gly Asn Ser Ser Ser Gln Val Pro Leu Lys
            1060                1065                1070        
Glu Asn Asp Val Leu His Lys Arg Trp Ser Ile Val Ser Ser Pro Glu
        1075                1080                1085            
Arg Glu Ile Thr Leu Val Asn Leu Lys Lys Asp Ala Lys Tyr Gly Leu
    1090                1095                1100                
Gly Phe Gln Ile Ile Gly Gly Glu Lys Met Gly Arg Leu Asp Leu Gly
1105                1110                1115                1120
Ile Phe Ile Ser Ser Val Ala Pro Gly Gly Pro Ala Asp Leu Asp Gly
                1125                1130                1135    
Cys Leu Lys Pro Gly Asp Arg Leu Ile Ser Val Asn Ser Val Ser Leu
            1140                1145                1150        
Glu Gly Val Ser His His Ala Ala Ile Glu Ile Leu Gln Asn Ala Pro
        1155                1160                1165            
Glu Asp Val Thr Leu Val Ile Ser Gln Pro Lys Glu Lys Ile Ser Lys
    1170                1175                1180                
Val Pro Ser Thr Pro Val His Leu Thr Asn Glu Met Lys Asn Tyr Met
1185                1190                1195                1200
Lys Lys Ser Ser Tyr Met Gln Asp Ser Ala Ile Asp Ser Ser Ser Lys
                1205                1210                1215    
Asp His His Trp Ser Arg Gly Thr Leu Arg His Ile Ser Glu Asn Ser
            1220                1225                1230        
Phe Gly Pro Ser Gly Gly Leu Arg Glu Gly Ser Leu Ser Ser Gln Asp
        1235                1240                1245            
Ser Arg Thr Glu Ser Ala Ser Leu Ser Gln Ser Gln Val Asn Gly Phe
    1250                1255                1260                
Phe Ala Ser His Leu Gly Asp Gln Thr Trp Gln Glu Ser Gln His Gly
1265                1270                1275                1280
Ser Pro Ser Pro Ser Val Ile Ser Lys Ala Thr Glu Lys Glu Thr Phe
                1285                1290                1295    
Thr Asp Ser Asn Gln Ser Lys Thr Lys Lys Pro Gly Ile Ser Asp Val
            1300                1305                1310        
Thr Asp Tyr Ser Asp Arg Gly Asp Ser Asp Met Asp Glu Ala Thr Tyr
        1315                1320                1325            
Ser Ser Ser Gln Asp His Gln Thr Pro Lys Gln Glu Ser Ser Ser Ser
    1330                1335                1340                
Val Asn Thr Ser Asn Lys Met Asn Phe Lys Thr Phe Ser Ser Ser Pro
1345                1350                1355                1360
Pro Lys Pro Gly Asp Ile Phe Glu Val Glu Leu Ala Lys Asn Asp Asn
                1365                1370                1375    
Ser Leu Gly Ile Ser Val Thr Gly Gly Val Asn Thr Ser Val Arg His
            1380                1385                1390        
Gly Gly Ile Tyr Val Lys Ala Val Ile Pro Gln Gly Ala Ala Glu Ser
        1395                1400                1405            
Asp Gly Arg Ile His Lys Gly Asp Arg Val Leu Ala Val Asn Gly Val
    1410                1415                1420                
Ser Leu Glu Gly Ala Thr His Lys Gln Ala Val Glu Thr Leu Arg Asn
1425                1430                1435                1440
Thr Gly Gln Val Val His Leu Leu Leu Glu Lys Gly Gln Ser Pro Thr
                1445                1450                1455    
Ser Lys Glu His Val Pro Val Thr Pro Gln Cys Thr Leu Ser Asp Gln
            1460                1465                1470        
Asn Ala Gln Gly Gln Gly Pro Glu Lys Val Lys Lys Thr Thr Gln Val
        1475                1480                1485            
Lys Asp Tyr Ser Phe Val Thr Glu Glu Asn Thr Phe Glu Val Lys Leu
    1490                1495                1500                
Phe Lys Asn Ser Ser Gly Leu Gly Phe Ser Phe Ser Arg Glu Asp Asn
1505                1510                1515                1520
Leu Ile Pro Glu Gln Ile Asn Ala Ser Ile Val Arg Val Lys Lys Leu
                1525                1530                1535    
Phe Pro Gly Gln Pro Ala Ala Glu Ser Gly Lys Ile Asp Val Gly Asp
            1540                1545                1550        
Val Ile Leu Lys Val Asn Gly Ala Ser Leu Lys Gly Leu Ser Gln Gln
        1555                1560                1565            
Glu Val Ile Ser Ala Leu Arg Gly Thr Ala Pro Glu Val Phe Leu Leu
    1570                1575                1580                
Leu Cys Arg Pro Pro Pro Gly Val Leu Pro Glu Ile Asp Thr Ala Leu
1585                1590                1595                1600
Leu Thr Pro Leu Gln Ser Pro Ala Gln Val Leu Pro Asn Ser Ser Lys
                1605                1610                1615    
Asp Ser Ser Gln Pro Ser Cys Val Glu Gln Ser Thr Ser Ser Asp Glu
            1620                1625                1630        
Asn Glu Met Ser Asp Lys Ser Lys Lys Gln Cys Lys Ser Pro Ser Arg
        1635                1640                1645            
Arg Asp Ser Tyr Ser Asp Ser Ser Gly Ser Gly Glu Asp Asp Leu Val
    1650                1655                1660                
Thr Ala Pro Ala Asn Ile Ser Asn Ser Thr Trp Ser Ser Ala Leu His
1665                1670                1675                1680
Gln Thr Leu Ser Asn Met Val Ser Gln Ala Gln Ser His His Glu Ala
                1685                1690                1695    
Pro Lys Ser Gln Glu Asp Thr Ile Cys Thr Met Phe Tyr Tyr Pro Gln
            1700                1705                1710        
Lys Ile Pro Asn Lys Pro Glu Phe Glu Asp Ser Asn Pro Ser Pro Leu
        1715                1720                1725            
Pro Pro Asp Met Ala Pro Gly Gln Ser Tyr Gln Pro Gln Ser Glu Ser
    1730                1735                1740                
Ala Ser Ser Ser Ser Met Asp Lys Tyr His Ile His His Ile Ser Glu
1745                1750                1755                1760
Pro Thr Arg Gln Glu Asn Trp Thr Pro Leu Lys Asn Asp Leu Glu Asn
                1765                1770                1775    
His Leu Glu Asp Phe Glu Leu Glu Val Glu Leu Leu Ile Thr Leu Ile
            1780                1785                1790        
Lys Ser Glu Lys Gly Ser Leu Gly Phe Thr Val Thr Lys Gly Asn Gln
        1795                1800                1805            
Arg Ile Gly Cys Tyr Val His Asp Val Ile Gln Asp Pro Ala Lys Ser
    1810                1815                1820                
Asp Gly Arg Leu Lys Pro Gly Asp Arg Leu Ile Lys Val Asn Asp Thr
1825                1830                1835                1840
Asp Val Thr Asn Met Thr His Thr Asp Ala Val Asn Leu Leu Arg Ala
                1845                1850                1855    
Ala Ser Lys Thr Val Arg Leu Val Ile Gly Arg Val Leu Glu Leu Pro
            1860                1865                1870        
Arg Ile Pro Met Leu Pro His Leu Leu Pro Asp Ile Thr Leu Thr Cys
        1875                1880                1885            
Asn Lys Glu Glu Leu Gly Phe Ser Leu Cys Gly Gly His Asp Ser Leu
    1890                1895                1900                
Tyr Gln Val Val Tyr Ile Ser Asp Ile Asn Pro Arg Ser Val Ala Ala
1905                1910                1915                1920
Ile Glu Gly Asn Leu Gln Leu Leu Asp Val Ile His Tyr Val Asn Gly
                1925                1930                1935    
Val Ser Thr Gln Gly Met Thr Leu Glu Glu Val Asn Arg Ala Leu Asp
            1940                1945                1950        
Met Ser Leu Pro Ser Leu Val Leu Lys Ala Thr Arg Asn Asp Leu Pro
        1955                1960                1965            
Val Val Pro Ser Ser Lys Arg Ser Ala Val Ser Ala Pro Lys Ser Thr
    1970                1975                1980                
Lys Gly Asn Gly Ser Tyr Ser Val Gly Ser Cys Ser Gln Pro Ala Leu
1985                1990                1995                2000
Thr Pro Asn Asp Ser Phe Ser Thr Val Ala Gly Glu Glu Ile Asn Glu
                2005                2010                2015    
Ile Ser Tyr Pro Lys Gly Lys Cys Ser Thr Tyr Gln Ile Lys Gly Ser
            2020                2025                2030        
Pro Asn Leu Thr Leu Pro Lys Glu Ser Tyr Ile Gln Glu Asp Asp Ile
        2035                2040                2045            
Tyr Asp Asp Ser Gln Glu Ala Glu Val Ile Gln Ser Leu Leu Asp Val
    2050                2055                2060                
Val Asp Glu Glu Ala Gln Asn Leu Leu Asn Glu Asn Asn Ala Ala Gly
2065                2070                2075                2080
Tyr Ser Cys Gly Pro Gly Thr Leu Lys Met Asn Gly Lys Leu Ser Glu
                2085                2090                2095    
Glu Arg Thr Glu Asp Thr Asp Cys Asp Gly Ser Pro Leu Pro Glu Tyr
            2100                2105                2110        
Phe Thr Glu Ala Thr Lys Met Asn Gly Cys Glu Glu Tyr Cys Glu Glu
        2115                2120                2125            
Lys Val Lys Ser Glu Ser Leu Ile Gln Lys Pro Gln Glu Lys Lys Thr
    2130                2135                2140                
Asp Asp Asp Glu Ile Thr Trp Gly Asn Asp Glu Leu Pro Ile Glu Arg
2145                2150                2155                2160
Thr Asn His Glu Asp Ser Asp Lys Asp His Ser Phe Leu Thr Asn Asp
                2165                2170                2175    
Glu Leu Ala Val Leu Pro Val Val Lys Val Leu Pro Ser Gly Lys Tyr
            2180                2185                2190        
Thr Gly Ala Asn Leu Lys Ser Val Ile Arg Val Leu Arg Gly Leu Leu
        2195                2200                2205            
Asp Gln Gly Ile Pro Ser Lys Glu Leu Glu Asn Leu Gln Glu Leu Lys
    2210                2215                2220                
Pro Leu Asp Gln Cys Leu Ile Gly Gln Thr Lys Glu Asn Arg Arg Lys
2225                2230                2235                2240
Asn Arg Tyr Lys Asn Ile Leu Pro Tyr Asp Ala Thr Arg Val Pro Leu
                2245                2250                2255    
Gly Asp Glu Gly Gly Tyr Ile Asn Ala Ser Phe Ile Lys Ile Pro Val
            2260                2265                2270        
Gly Lys Glu Glu Phe Val Tyr Ile Ala Cys Gln Gly Pro Leu Pro Thr
        2275                2280                2285            
Thr Val Gly Asp Phe Trp Gln Met Ile Trp Glu Gln Lys Ser Thr Val
    2290                2295                2300                
Ile Ala Met Met Thr Gln Glu Val Glu Gly Glu Lys Ile Lys Cys Gln
2305                2310                2315                2320
Arg Tyr Trp Pro Asn Ile Leu Gly Lys Thr Thr Met Val Ser Asn Arg
                2325                2330                2335    
Leu Arg Leu Ala Leu Val Arg Met Gln Gln Leu Lys Gly Phe Val Val
            2340                2345                2350        
Arg Ala Met Thr Leu Glu Asp Ile Gln Thr Arg Glu Val Arg His Ile
        2355                2360                2365            
Ser His Leu Asn Phe Thr Ala Trp Pro Asp His Asp Thr Pro Ser Gln
    2370                2375                2380                
Pro Asp Asp Leu Leu Thr Phe Ile Ser Tyr Met Arg His Ile His Arg
2385                2390                2395                2400
Ser Gly Pro Ile Ile Thr His Cys Ser Ala Gly Ile Gly Arg Ser Gly
                2405                2410                2415    
Thr Leu Ile Cys Ile Asp Val Val Leu Gly Leu Ile Ser Gln Asp Leu
            2420                2425                2430        
Asp Phe Asp Ile Ser Asp Leu Val Arg Cys Met Arg Leu Gln Arg His
        2435                2440                2445            
Gly Met Val Gln Thr Glu Asp Gln Tyr Ile Phe Cys Tyr Gln Val Ile
    2450                2455                2460                
Leu Tyr Val Leu Thr Arg Leu Gln Ala Glu Glu Glu Gln Lys Gln Gln
2465                2470                2475                2480
Pro Gln Leu Leu Lys
                2485


<210> 1350
<211> 897
<212> PRT
<213> Homo sapiens

<400> 1350
Met Asn Ile Leu Gly Ser Ser Cys Gly Ser Pro Asn Ser Ala Asp Thr
 1               5                  10                  15      
Ser Ser Asp Phe Lys Asp Leu Trp Thr Lys Leu Lys Glu Cys His Asp
            20                  25                  30          
Arg Glu Val Gln Gly Leu Gln Val Lys Val Thr Lys Leu Lys Gln Glu
        35                  40                  45              
Arg Ile Leu Asp Ala Gln Arg Leu Glu Glu Phe Phe Thr Lys Asn Gln
    50                  55                  60                  
Gln Leu Arg Glu Gln Gln Lys Val Leu His Glu Thr Ile Lys Val Leu
65                  70                  75                  80  
Glu Asp Arg Leu Arg Ala Gly Leu Cys Asp Arg Cys Ala Val Thr Glu
                85                  90                  95      
Glu His Met Arg Lys Lys Gln Gln Glu Phe Glu Asn Ile Arg Gln Gln
            100                 105                 110         
Asn Leu Lys Leu Ile Thr Glu Leu Met Asn Glu Arg Asn Thr Leu Gln
        115                 120                 125             
Glu Glu Asn Lys Lys Leu Ser Glu Gln Leu Gln Gln Lys Ile Glu Asn
    130                 135                 140                 
Asp Gln Gln His Gln Ala Ala Glu Leu Glu Cys Glu Glu Asp Val Ile
145                 150                 155                 160 
Pro Asp Ser Pro Ile Thr Ala Phe Ser Phe Ser Gly Val Asn Arg Leu
                165                 170                 175     
Arg Arg Lys Glu Asn Pro His Val Arg Tyr Ile Glu Gln Thr His Thr
            180                 185                 190         
Lys Leu Glu His Ser Val Cys Ala Asn Glu Met Arg Lys Val Ser Lys
        195                 200                 205             
Ser Ser Thr His Pro Gln His Asn Pro Asn Glu Asn Glu Ile Leu Val
    210                 215                 220                 
Ala Asp Thr Tyr Asp Gln Ser Gln Ser Pro Met Ala Lys Ala His Gly
225                 230                 235                 240 
Thr Ser Ser Tyr Thr Pro Asp Lys Ser Ser Phe Asn Leu Ala Thr Val
                245                 250                 255     
Val Ala Glu Thr Leu Gly Leu Gly Val Gln Glu Glu Ser Glu Thr Gln
            260                 265                 270         
Gly Pro Met Ser Pro Leu Gly Asp Glu Leu Tyr His Cys Leu Glu Gly
        275                 280                 285             
Asn His Lys Lys Gln Pro Phe Glu Glu Ser Thr Arg Asn Thr Glu Asp
    290                 295                 300                 
Ser Leu Arg Phe Ser Asp Ser Thr Ser Lys Thr Pro Pro Gln Glu Glu
305                 310                 315                 320 
Leu Pro Thr Arg Val Ser Ser Pro Val Phe Gly Ala Thr Ser Ser Ile
                325                 330                 335     
Lys Ser Gly Leu Asp Leu Asn Thr Ser Leu Ser Pro Ser Leu Leu Gln
            340                 345                 350         
Pro Gly Lys Lys Lys His Leu Lys Thr Leu Pro Phe Ser Asn Thr Cys
        355                 360                 365             
Ile Ser Arg Leu Glu Lys Thr Arg Ser Lys Ser Glu Asp Ser Ala Leu
    370                 375                 380                 
Phe Thr His His Ser Leu Gly Ser Glu Val Asn Lys Ile Ile Ile Gln
385                 390                 395                 400 
Ser Ser Asn Lys Gln Ile Leu Ile Asn Lys Asn Ile Ser Glu Ser Leu
                405                 410                 415     
Gly Glu Gln Asn Arg Thr Glu Tyr Gly Lys Asp Ser Asn Thr Asp Lys
            420                 425                 430         
His Leu Glu Pro Leu Lys Ser Leu Gly Gly Arg Thr Ser Lys Arg Lys
        435                 440                 445             
Lys Thr Glu Glu Glu Ser Glu His Glu Val Ser Cys Pro Gln Ala Ser
    450                 455                 460                 
Phe Asp Lys Glu Asn Ala Phe Pro Phe Pro Met Asp Asn Gln Phe Ser
465                 470                 475                 480 
Met Asn Gly Asp Cys Val Met Asp Lys Pro Leu Asp Leu Ser Asp Arg
                485                 490                 495     
Phe Ser Ala Ile Gln Arg Gln Glu Lys Ser Gln Gly Ser Glu Thr Ser
            500                 505                 510         
Lys Asn Lys Phe Arg Gln Val Thr Leu Tyr Glu Ala Leu Lys Thr Ile
        515                 520                 525             
Pro Lys Gly Phe Ser Ser Ser Arg Lys Ala Ser Asp Gly Asn Cys Thr
    530                 535                 540                 
Leu Pro Lys Asp Ser Pro Gly Glu Pro Cys Ser Gln Glu Cys Ile Ile
545                 550                 555                 560 
Leu Gln Pro Leu Asn Lys Cys Ser Pro Asp Asn Lys Pro Ser Leu Gln
                565                 570                 575     
Ile Lys Glu Glu Asn Ala Val Phe Lys Ile Pro Leu Arg Pro Arg Glu
            580                 585                 590         
Ser Leu Glu Thr Glu Asn Val Leu Asp Asp Ile Lys Ser Ala Gly Ser
        595                 600                 605             
His Glu Pro Ile Lys Ile Gln Thr Arg Ser Asp His Gly Gly Cys Glu
    610                 615                 620                 
Leu Ala Ser Val Leu Gln Leu Asn Pro Cys Arg Thr Gly Lys Ile Lys
625                 630                 635                 640 
Ser Leu Gln Asn Asn Gln Asp Val Ser Phe Glu Asn Ile Gln Trp Ser
                645                 650                 655     
Ile Asp Pro Gly Ala Asp Leu Ser Gln Tyr Lys Met Asp Val Thr Val
            660                 665                 670         
Ile Asp Thr Lys Asp Gly Ser Gln Ser Lys Leu Gly Gly Glu Thr Val
        675                 680                 685             
Asp Met Asp Cys Thr Leu Val Ser Glu Thr Val Leu Leu Lys Met Lys
    690                 695                 700                 
Lys Gln Glu Gln Lys Gly Glu Lys Ser Ser Asn Glu Glu Arg Lys Met
705                 710                 715                 720 
Asn Asp Ser Leu Glu Asp Met Phe Asp Arg Thr Thr His Glu Glu Tyr
                725                 730                 735     
Glu Ser Cys Leu Ala Asp Ser Phe Ser Gln Ala Ala Asp Glu Glu Glu
            740                 745                 750         
Glu Leu Ser Thr Ala Thr Lys Lys Leu His Thr His Gly Asp Lys Gln
        755                 760                 765             
Asp Lys Val Lys Gln Lys Ala Phe Val Glu Pro Tyr Phe Lys Gly Asp
    770                 775                 780                 
Glu Arg Glu Thr Ser Leu Gln Asn Phe Pro His Ile Glu Val Val Arg
785                 790                 795                 800 
Lys Lys Glu Glu Arg Arg Lys Leu Leu Gly His Thr Cys Lys Glu Cys
                805                 810                 815     
Glu Ile Tyr Tyr Ala Asp Met Pro Ala Glu Glu Arg Glu Lys Lys Leu
            820                 825                 830         
Ala Ser Cys Ser Arg His Arg Phe Arg Tyr Ile Pro Pro Asn Thr Pro
        835                 840                 845             
Glu Asn Phe Trp Glu Val Gly Phe Pro Ser Thr Gln Thr Cys Met Glu
    850                 855                 860                 
Arg Gly Tyr Ile Lys Glu Asp Leu Asp Pro Cys Pro Arg Pro Lys Arg
865                 870                 875                 880 
Arg Gln Pro Tyr Asn Ala Ile Phe Ser Pro Lys Gly Lys Glu Gln Lys
                885                 890                 895     
Thr
    


<210> 1351
<211> 1845
<212> PRT
<213> Homo sapiens

<400> 1351
Met Gly Leu Cys Gly Leu Leu Glu Arg Cys Trp Leu His His Asp Pro
 1               5                  10                  15      
Asp Gly Val Leu Thr Leu Asn Ala Glu Asn Thr Asn Tyr Ala Tyr Gln
            20                  25                  30          
Val Pro Asn Phe His Lys Cys Glu Ile Cys Leu Leu Ser Phe Pro Lys
        35                  40                  45              
Glu Ser Gln Phe Gln Arg His Met Arg Asp His Glu Arg Asn Asp Lys
    50                  55                  60                  
Pro His Arg Cys Asp Gln Cys Pro Gln Thr Phe Asn Val Glu Phe Asn
65                  70                  75                  80  
Leu Thr Leu His Lys Cys Thr His Ser Gly Glu Asp Pro Thr Cys Pro
                85                  90                  95      
Val Cys Asn Lys Lys Phe Ser Arg Val Ala Ser Leu Lys Ala His Ile
            100                 105                 110         
Met Leu His Glu Lys Glu Glu Asn Leu Ile Cys Ser Glu Cys Gly Asp
        115                 120                 125             
Glu Phe Thr Leu Gln Ser Gln Leu Ala Val His Met Glu Glu His Arg
    130                 135                 140                 
Gln Glu Leu Ala Gly Thr Arg Gln His Ala Cys Lys Ala Cys Lys Lys
145                 150                 155                 160 
Glu Phe Glu Thr Ser Ser Glu Leu Lys Glu His Met Lys Thr His Tyr
                165                 170                 175     
Lys Ile Arg Val Ser Ser Thr Arg Ser Tyr Asn Arg Asn Ile Asp Arg
            180                 185                 190         
Ser Gly Phe Thr Tyr Ser Cys Pro His Cys Gly Lys Thr Phe Gln Lys
        195                 200                 205             
Pro Ser Gln Leu Thr Arg His Ile Arg Ile His Thr Gly Glu Arg Pro
    210                 215                 220                 
Phe Lys Cys Ser Glu Cys Gly Lys Ala Phe Asn Gln Lys Gly Ala Leu
225                 230                 235                 240 
Gln Thr His Met Ile Lys His Thr Gly Glu Lys Pro His Ala Cys Ala
                245                 250                 255     
Phe Cys Pro Ala Ala Phe Ser Gln Lys Gly Asn Leu Gln Ser His Val
            260                 265                 270         
Gln Arg Val His Ser Glu Val Lys Asn Gly Pro Thr Tyr Asn Cys Thr
        275                 280                 285             
Glu Cys Ser Cys Val Phe Lys Ser Leu Gly Ser Leu Asn Thr His Ile
    290                 295                 300                 
Ser Lys Met His Met Gly Gly Pro Gln Asn Ser Thr Ser Ser Thr Glu
305                 310                 315                 320 
Thr Ala His Val Leu Thr Ala Thr Leu Phe Gln Thr Leu Pro Leu Gln
                325                 330                 335     
Gln Thr Glu Ala Gln Ala Thr Ser Ala Ser Ser Gln Pro Ser Ser Gln
            340                 345                 350         
Ala Val Ser Asp Val Ile Gln Gln Leu Leu Glu Leu Ser Glu Pro Ala
        355                 360                 365             
Pro Val Glu Ser Gly Gln Ser Pro Gln Pro Gly Gln Gln Leu Ser Ile
    370                 375                 380                 
Thr Val Gly Ile Asn Gln Asp Ile Leu Gln Gln Ala Leu Glu Asn Ser
385                 390                 395                 400 
Gly Leu Ser Ser Ile Pro Ala Ala Ala His Pro Asn Asp Ser Cys His
                405                 410                 415     
Ala Lys Thr Ser Ala Pro His Ala Gln Asn Pro Asp Val Ser Ser Val
            420                 425                 430         
Ser Asn Glu Gln Thr Asp Pro Thr Asp Ala Glu Gln Glu Lys Glu Gln
        435                 440                 445             
Glu Ser Pro Glu Lys Leu Asp Lys Lys Glu Lys Lys Met Ile Lys Lys
    450                 455                 460                 
Lys Ser Pro Phe Leu Pro Gly Ser Ile Arg Glu Glu Asn Gly Val Arg
465                 470                 475                 480 
Trp His Val Cys Pro Tyr Cys Ala Lys Glu Phe Arg Lys Pro Ser Asp
                485                 490                 495     
Leu Val Arg His Ile Arg Ile His Thr His Glu Lys Pro Phe Lys Cys
            500                 505                 510         
Pro Gln Cys Phe Arg Ala Phe Ala Val Lys Ser Thr Leu Thr Ala His
        515                 520                 525             
Ile Lys Thr His Thr Gly Ile Lys Ala Phe Lys Cys Gln Tyr Cys Met
    530                 535                 540                 
Lys Ser Phe Ser Thr Ser Gly Ser Leu Lys Val His Ile Arg Leu His
545                 550                 555                 560 
Thr Gly Val Arg Pro Phe Ala Cys Pro His Cys Asp Lys Lys Phe Arg
                565                 570                 575     
Thr Ser Gly His Arg Lys Thr His Ile Ala Ser His Phe Lys His Thr
            580                 585                 590         
Glu Leu Arg Lys Met Arg His Gln Arg Lys Pro Ala Lys Val Arg Val
        595                 600                 605             
Gly Lys Thr Asn Val Pro Val Pro Asp Ile Pro Leu Gln Glu Pro Ile
    610                 615                 620                 
Leu Ile Thr Asp Leu Gly Leu Ile Gln Pro Ile Pro Lys Asn Gln Phe
625                 630                 635                 640 
Phe Gln Ser Tyr Phe Asn Asn Asn Phe Val Asn Glu Ala Asp Arg Pro
                645                 650                 655     
Tyr Lys Cys Phe Tyr Cys His Arg Ala Tyr Lys Lys Ser Cys His Leu
            660                 665                 670         
Lys Gln His Ile Arg Ser His Thr Gly Glu Lys Pro Phe Lys Cys Ser
        675                 680                 685             
Gln Cys Gly Arg Gly Phe Val Ser Ala Gly Val Leu Lys Ala His Ile
    690                 695                 700                 
Arg Thr His Thr Gly Leu Lys Ser Phe Lys Cys Leu Ile Cys Asn Gly
705                 710                 715                 720 
Ala Phe Thr Thr Gly Gly Ser Leu Arg Arg His Met Gly Ile His Asn
                725                 730                 735     
Asp Leu Arg Pro Tyr Met Cys Pro Tyr Cys Gln Lys Thr Phe Lys Thr
            740                 745                 750         
Ser Leu Asn Cys Lys Lys His Met Lys Thr His Arg Tyr Glu Leu Ala
        755                 760                 765             
Gln Gln Leu Gln Gln His Gln Gln Ala Ala Ser Ile Asp Asp Ser Thr
    770                 775                 780                 
Val Asp Gln Gln Ser Met Gln Ala Ser Thr Gln Met Gln Val Glu Ile
785                 790                 795                 800 
Glu Ser Asp Glu Leu Pro Gln Thr Ala Glu Val Val Ala Ala Asn Pro
                805                 810                 815     
Glu Ala Met Leu Asp Leu Glu Pro Gln His Val Val Gly Thr Glu Glu
            820                 825                 830         
Ala Gly Leu Gly Gln Gln Leu Ala Asp Gln Pro Leu Glu Ala Asp Glu
        835                 840                 845             
Asp Gly Phe Val Ala Pro Gln Asp Pro Leu Arg Gly His Val Asp Gln
    850                 855                 860                 
Phe Glu Glu Gln Ser Pro Ala Gln Gln Ser Phe Glu Pro Ala Gly Leu
865                 870                 875                 880 
Pro Gln Gly Phe Thr Val Thr Asp Thr Tyr His Gln Gln Pro Gln Phe
                885                 890                 895     
Pro Pro Val Gln Gln Leu Gln Asp Ser Ser Thr Leu Glu Ser Gln Ala
            900                 905                 910         
Leu Ser Thr Ser Phe His Gln Gln Ser Leu Leu Gln Ala Pro Ser Ser
        915                 920                 925             
Asp Gly Met Asn Val Thr Thr Arg Leu Ile Gln Glu Ser Ser Gln Glu
    930                 935                 940                 
Glu Leu Asp Leu Gln Ala Gln Gly Ser Gln Phe Leu Glu Asp Asn Glu
945                 950                 955                 960 
Asp Gln Ser Arg Arg Ser Tyr Arg Cys Asp Tyr Cys Asn Lys Gly Phe
                965                 970                 975     
Lys Lys Ser Ser His Leu Lys Gln His Val Arg Ser His Thr Gly Glu
            980                 985                 990         
Lys Pro Tyr Lys Cys Lys Leu Cys Gly Arg Gly Phe Val Ser Ser Gly
        995                 1000                1005            
Val Leu Lys Ser His Glu Lys Thr His Thr Gly Val Lys Ala Phe Ser
    1010                1015                1020                
Cys Ser Val Cys Asn Ala Ser Phe Thr Thr Asn Gly Ser Leu Thr Arg
1025                1030                1035                1040
His Met Ala Thr His Met Ser Met Lys Pro Tyr Lys Cys Pro Phe Cys
                1045                1050                1055    
Glu Glu Gly Phe Arg Thr Thr Val His Cys Lys Lys His Met Lys Arg
            1060                1065                1070        
His Gln Thr Val Pro Ser Ala Val Ser Ala Thr Gly Glu Thr Glu Gly
        1075                1080                1085            
Gly Asp Ile Cys Met Glu Glu Glu Glu Glu His Ser Asp Arg Asn Ala
    1090                1095                1100                
Ser Arg Lys Ser Arg Pro Glu Val Ile Thr Phe Thr Glu Glu Glu Thr
1105                1110                1115                1120
Ala Gln Leu Ala Lys Ile Arg Pro Gln Glu Ser Ala Thr Val Ser Glu
                1125                1130                1135    
Lys Val Leu Val Gln Ser Ala Ala Glu Lys Asp Arg Ile Ser Glu Leu
            1140                1145                1150        
Arg Asp Lys Gln Ala Glu Leu Gln Asp Glu Pro Lys His Ala Asn Cys
        1155                1160                1165            
Cys Thr Tyr Cys Pro Lys Ser Phe Lys Lys Pro Ser Asp Leu Val Arg
    1170                1175                1180                
His Val Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys
1185                1190                1195                1200
Gly Lys Ser Phe Thr Val Lys Ser Thr Leu Asp Cys His Val Lys Thr
                1205                1210                1215    
His Thr Gly Gln Lys Leu Phe Ser Cys His Val Cys Ser Asn Ala Phe
            1220                1225                1230        
Ser Thr Lys Gly Ser Leu Lys Val His Met Arg Leu His Thr Gly Ala
        1235                1240                1245            
Lys Pro Phe Lys Cys Pro His Cys Glu Leu Arg Phe Arg Thr Ser Gly
    1250                1255                1260                
Arg Arg Lys Thr His Met Gln Phe His Tyr Lys Pro Asp Pro Lys Lys
1265                1270                1275                1280
Ala Arg Lys Pro Met Thr Arg Ser Ser Ser Glu Gly Leu Gln Pro Val
                1285                1290                1295    
Asn Leu Leu Asn Ser Ser Ser Thr Asp Pro Asn Val Phe Ile Met Asn
            1300                1305                1310        
Asn Ser Val Leu Thr Gly Gln Phe Asp Gln Asn Leu Leu Gln Pro Gly
        1315                1320                1325            
Leu Val Gly Gln Ala Ile Leu Pro Ala Ser Val Ser Ala Gly Gly Asp
    1330                1335                1340                
Leu Thr Val Ser Leu Thr Asp Gly Ser Leu Ala Thr Leu Glu Gly Ile
1345                1350                1355                1360
Gln Leu Gln Leu Ala Ala Asn Leu Val Gly Pro Asn Val Gln Ile Ser
                1365                1370                1375    
Gly Ile Asp Ala Ala Ser Ile Asn Asn Ile Thr Leu Gln Ile Asp Pro
            1380                1385                1390        
Ser Ile Leu Gln Gln Thr Leu Gln Gln Gly Asn Leu Leu Ala Gln Gln
        1395                1400                1405            
Leu Thr Gly Glu Pro Gly Leu Ala Pro Gln Asn Ser Ser Leu Gln Thr
    1410                1415                1420                
Ser Asp Ser Thr Val Pro Ala Ser Val Val Ile Gln Pro Ile Ser Gly
1425                1430                1435                1440
Leu Ser Leu Gln Pro Thr Val Thr Ser Ala Asn Leu Thr Ile Gly Pro
                1445                1450                1455    
Leu Ser Glu Gln Asp Ser Val Leu Thr Thr Asn Ser Ser Gly Thr Gln
            1460                1465                1470        
Asp Leu Thr Gln Val Met Thr Ser Gln Gly Leu Val Ser Pro Ser Gly
        1475                1480                1485            
Gly Pro His Glu Ile Thr Leu Thr Ile Asn Asn Ser Ser Leu Ser Gln
    1490                1495                1500                
Val Leu Ala Gln Ala Ala Gly Pro Thr Ala Thr Ser Ser Ser Gly Ser
1505                1510                1515                1520
Pro Gln Glu Ile Thr Leu Thr Ile Ser Glu Leu Asn Thr Thr Ser Gly
                1525                1530                1535    
Ser Leu Pro Ser Thr Thr Pro Thr Ser Pro Ser Ala Ile Ser Thr Gln
            1540                1545                1550        
Asn Leu Val Met Ser Ser Ser Gly Val Gly Gly Asp Ala Ser Val Thr
        1555                1560                1565            
Leu Thr Leu Ala Asp Thr Gln Gly Met Leu Ser Gly Gly Leu Asp Thr
    1570                1575                1580                
Val Thr Leu Asn Ile Thr Ser Gln Gly Gln Gln Phe Pro Ala Leu Leu
1585                1590                1595                1600
Thr Asp Pro Ser Leu Ser Gly Gln Gly Gly Ala Gly Ser Pro Gln Val
                1605                1610                1615    
Ile Leu Val Ser His Thr Pro Gln Ser Ala Ser Ala Ala Cys Glu Glu
            1620                1625                1630        
Ile Ala Tyr Gln Val Ala Gly Val Ser Gly Asn Leu Ala Pro Gly Asn
        1635                1640                1645            
Gln Pro Glu Lys Glu Gly Arg Ala His Gln Cys Leu Glu Cys Asp Arg
    1650                1655                1660                
Ala Phe Ser Ser Ala Ala Val Leu Met His His Ser Lys Glu Val His
1665                1670                1675                1680
Gly Arg Glu Arg Ile His Gly Cys Pro Val Cys Arg Lys Ala Phe Lys
                1685                1690                1695    
Arg Ala Thr His Leu Lys Glu His Met Gln Thr His Gln Ala Gly Pro
            1700                1705                1710        
Ser Leu Ser Ser Gln Lys Pro Arg Val Phe Lys Cys Asp Thr Cys Glu
        1715                1720                1725            
Lys Ala Phe Ala Lys Pro Ser Gln Leu Glu Arg His Ser Arg Ile His
    1730                1735                1740                
Thr Gly Glu Arg Pro Phe His Cys Thr Leu Cys Glu Lys Ala Phe Asn
1745                1750                1755                1760
Gln Lys Ser Ala Leu Gln Val His Met Lys Lys His Thr Gly Glu Arg
                1765                1770                1775    
Pro Tyr Lys Cys Ala Tyr Cys Val Met Gly Phe Thr Gln Lys Ser Asn
            1780                1785                1790        
Met Lys Leu His Met Lys Arg Ala His Ser Tyr Ala Gly Ala Leu Gln
        1795                1800                1805            
Glu Ser Ala Gly His Pro Glu Gln Asp Gly Glu Glu Leu Ser Arg Thr
    1810                1815                1820                
Leu His Leu Glu Glu Val Val Gln Glu Ala Ala Gly Glu Trp Gln Ala
1825                1830                1835                1840
Leu Thr His Val Phe
                1845


<210> 1352
<211> 1816
<212> PRT
<213> Homo sapiens

<400> 1352
Met Ser Ala Gly Gly Arg Asp Glu Glu Arg Arg Lys Leu Ala Asp Ile
 1               5                  10                  15      
Ile His His Trp Asn Ala Asn Arg Leu Asp Leu Phe Glu Ile Ser Gln
            20                  25                  30          
Pro Thr Glu Asp Leu Glu Phe His Gly Val Met Arg Phe Tyr Phe Gln
        35                  40                  45              
Asp Lys Ala Ala Gly Asn Phe Ala Thr Lys Cys Ile Arg Val Ser Ser
    50                  55                  60                  
Thr Ala Thr Thr Gln Asp Val Ile Glu Thr Leu Ala Glu Lys Phe Arg
65                  70                  75                  80  
Pro Asp Met Arg Met Leu Ser Ser Pro Lys Tyr Ser Leu Tyr Glu Val
                85                  90                  95      
His Val Ser Gly Glu Arg Arg Leu Asp Ile Asp Glu Lys Pro Leu Val
            100                 105                 110         
Val Gln Leu Asn Trp Asn Lys Asp Asp Arg Glu Gly Arg Phe Val Leu
        115                 120                 125             
Lys Asn Glu Asn Asp Ala Ile Pro Pro Lys Ala Gln Ser Asn Gly Pro
    130                 135                 140                 
Glu Lys Gln Glu Lys Glu Gly Val Ile Gln Asn Phe Lys Arg Thr Leu
145                 150                 155                 160 
Ser Lys Lys Glu Lys Lys Glu Lys Lys Lys Arg Glu Lys Glu Ala Leu
                165                 170                 175     
Arg Gln Ala Ser Asp Lys Asp Asp Arg Pro Phe Gln Gly Glu Asp Val
            180                 185                 190         
Glu Asn Ser Arg Leu Ala Ala Glu Val Tyr Lys Asp Met Pro Glu Thr
        195                 200                 205             
Ser Phe Thr Arg Thr Ile Ser Asn Pro Glu Val Val Met Lys Arg Arg
    210                 215                 220                 
Arg Gln Gln Lys Leu Glu Lys Arg Met Gln Glu Phe Arg Ser Ser Asp
225                 230                 235                 240 
Gly Arg Pro Asp Ser Gly Gly Thr Leu Arg Ile Tyr Ala Asp Ser Leu
                245                 250                 255     
Lys Pro Asn Ile Pro Tyr Lys Thr Ile Leu Leu Ser Thr Thr Asp Pro
            260                 265                 270         
Ala Asp Phe Ala Val Ala Glu Ala Leu Glu Lys Tyr Gly Leu Glu Lys
        275                 280                 285             
Glu Asn Pro Lys Asp Tyr Cys Ile Ala Arg Val Met Leu Pro Pro Gly
    290                 295                 300                 
Ala Gln His Ser Asp Glu Lys Gly Ala Lys Glu Ile Ile Leu Asp Asp
305                 310                 315                 320 
Asp Glu Cys Pro Leu Gln Ile Phe Arg Glu Trp Pro Ser Asp Lys Gly
                325                 330                 335     
Ile Leu Val Phe Gln Leu Lys Arg Arg Pro Pro Asp His Ile Pro Lys
            340                 345                 350         
Lys Thr Lys Lys His Leu Glu Gly Lys Thr Pro Lys Gly Lys Glu Arg
        355                 360                 365             
Ala Asp Gly Ser Gly Tyr Gly Ser Thr Leu Pro Pro Glu Lys Leu Pro
    370                 375                 380                 
Tyr Leu Val Glu Leu Ser Pro Asp Gly Ser Asp Ser Arg Asp Lys Pro
385                 390                 395                 400 
Lys Leu Tyr Arg Leu Gln Leu Ser Val Thr Glu Val Gly Thr Glu Lys
                405                 410                 415     
Leu Asp Asp Asn Ser Ile Gln Leu Phe Gly Pro Gly Ile Gln Pro His
            420                 425                 430         
His Cys Asp Leu Thr Asn Met Asp Gly Val Val Thr Val Thr Pro Arg
        435                 440                 445             
Ser Met Asp Ala Glu Thr Tyr Val Glu Gly Gln Arg Ile Ser Glu Thr
    450                 455                 460                 
Thr Met Leu Gln Ser Gly Met Lys Val Gln Phe Gly Ala Ser His Val
465                 470                 475                 480 
Phe Lys Phe Val Asp Pro Ser Gln Asp His Ala Leu Ala Lys Arg Ser
                485                 490                 495     
Val Asp Gly Gly Leu Met Val Lys Gly Pro Arg His Lys Pro Gly Ile
            500                 505                 510         
Val Gln Glu Thr Thr Phe Asp Leu Gly Gly Asp Ile His Ser Gly Thr
        515                 520                 525             
Ala Leu Pro Thr Ser Lys Ser Thr Thr Arg Leu Asp Ser Asp Arg Val
    530                 535                 540                 
Ser Ser Ala Ser Ser Thr Ala Glu Arg Gly Met Val Lys Pro Met Ile
545                 550                 555                 560 
Arg Val Glu Gln Gln Pro Asp Tyr Arg Arg Gln Glu Ser Arg Thr Gln
                565                 570                 575     
Asp Ala Ser Gly Pro Glu Leu Ile Leu Pro Ala Ser Ile Glu Phe Arg
            580                 585                 590         
Glu Ser Ser Glu Asp Ser Phe Leu Ser Ala Ile Ile Asn Tyr Thr Asn
        595                 600                 605             
Ser Ser Thr Val His Phe Lys Leu Ser Pro Thr Tyr Val Leu Tyr Met
    610                 615                 620                 
Ala Cys Arg Tyr Val Leu Ser Asn Gln Tyr Arg Pro Asp Ile Ser Pro
625                 630                 635                 640 
Thr Glu Arg Thr His Lys Val Ile Ala Val Val Asn Lys Met Val Ser
                645                 650                 655     
Met Met Glu Gly Val Ile Gln Lys Gln Lys Asn Ile Ala Gly Ala Leu
            660                 665                 670         
Ala Phe Trp Met Ala Asn Ala Ser Glu Leu Leu Asn Phe Ile Lys Gln
        675                 680                 685             
Asp Arg Asp Leu Ser Arg Ile Thr Leu Asp Ala Gln Asp Val Leu Ala
    690                 695                 700                 
His Leu Val Gln Met Ala Phe Lys Tyr Leu Val His Cys Leu Gln Ser
705                 710                 715                 720 
Glu Leu Asn Asn Tyr Met Pro Ala Phe Leu Asp Asp Pro Glu Glu Asn
                725                 730                 735     
Ser Leu Gln Arg Pro Lys Ile Asp Asp Val Leu His Thr Leu Thr Gly
            740                 745                 750         
Ala Met Ser Leu Leu Arg Arg Cys Arg Val Asn Ala Ala Leu Thr Ile
        755                 760                 765             
Gln Leu Phe Ser Gln Leu Phe His Phe Ile Asn Met Trp Leu Phe Asn
    770                 775                 780                 
Arg Leu Val Thr Asp Pro Asp Ser Gly Leu Cys Ser His Tyr Trp Gly
785                 790                 795                 800 
Ala Ile Ile Arg Gln Gln Leu Gly His Ile Glu Ala Trp Ala Glu Lys
                805                 810                 815     
Gln Gly Leu Glu Leu Ala Ala Asp Cys His Leu Ser Arg Ile Val Gln
            820                 825                 830         
Ala Thr Thr Leu Leu Thr Met Asp Lys Tyr Ala Pro Asp Asp Ile Pro
        835                 840                 845             
Asn Ile Asn Ser Thr Cys Phe Lys Leu Asn Ser Leu Gln Leu Gln Ala
    850                 855                 860                 
Leu Leu Gln Asn Tyr His Cys Ala Pro Asp Glu Pro Phe Ile Pro Thr
865                 870                 875                 880 
Asp Leu Ile Glu Asn Val Val Thr Val Ala Glu Asn Thr Ala Asp Glu
                885                 890                 895     
Leu Ala Arg Ser Asp Gly Arg Glu Val Gln Leu Glu Glu Asp Pro Asp
            900                 905                 910         
Leu Gln Leu Pro Phe Leu Leu Pro Glu Asp Gly Tyr Ser Cys Asp Val
        915                 920                 925             
Val Arg Asn Ile Pro Asn Gly Leu Gln Glu Phe Leu Asp Pro Leu Cys
    930                 935                 940                 
Gln Arg Gly Phe Cys Arg Leu Ile Pro His Thr Arg Ser Pro Gly Thr
945                 950                 955                 960 
Trp Thr Ile Tyr Phe Glu Gly Ala Asp Tyr Glu Ser His Leu Leu Arg
                965                 970                 975     
Glu Asn Thr Glu Leu Ala Gln Pro Leu Arg Lys Glu Pro Glu Ile Ile
            980                 985                 990         
Thr Val Thr Leu Lys Lys Gln Asn Gly Met Gly Leu Ser Ile Val Ala
        995                 1000                1005            
Ala Lys Gly Ala Gly Gln Asp Lys Leu Gly Ile Tyr Val Lys Ser Val
    1010                1015                1020                
Val Lys Gly Gly Ala Ala Asp Asp Gly Arg Leu Ala Ala Gly Asp Gln
1025                1030                1035                1040
Leu Leu Ser Val Asp Gly Arg Ser Leu Val Gly Leu Ser Gln Glu Arg
                1045                1050                1055    
Ala Ala Glu Leu Met Thr Arg Thr Ser Ser Val Val Thr Leu Glu Val
            1060                1065                1070        
Ala Lys Gln Gly Ala Ile Tyr His Gly Leu Ala Thr Leu Leu Asn Gln
        1075                1080                1085            
Pro Ser Pro Met Met Gln Arg Ile Ser Asp Arg Arg Gly Ser Gly Lys
    1090                1095                1100                
Pro Arg Pro Lys Ser Glu Gly Phe Glu Leu Tyr Asn Asn Ser Thr Gln
1105                1110                1115                1120
Asn Gly Ser Pro Glu Ser Pro Gln Leu Pro Trp Ala Glu Tyr Ser Glu
                1125                1130                1135    
Pro Lys Lys Leu Pro Gly Asp Asp Arg Leu Met Lys Asn Arg Ala Asp
            1140                1145                1150        
His Arg Ser Ser Pro Asn Val Ala Asn Gln Pro Pro Ser Pro Gly Gly
        1155                1160                1165            
Lys Ser Ala Tyr Ala Ser Gly Thr Thr Ala Lys Ile Thr Ser Val Ser
    1170                1175                1180                
Thr Gly Asn Leu Cys Thr Glu Glu Gln Thr Pro Pro Pro Arg Pro Glu
1185                1190                1195                1200
Ala Tyr Pro Ile Pro Thr Gln Thr Tyr Thr Arg Glu Tyr Phe Thr Phe
                1205                1210                1215    
Pro Ala Ser Lys Ser Gln Asp Arg Met Ala Pro Pro Gln Asn Gln Trp
            1220                1225                1230        
Pro Asn Tyr Glu Glu Lys Pro His Met His Thr Asp Ser Asn His Ser
        1235                1240                1245            
Ser Ile Ala Ile Gln Arg Val Thr Arg Ser Gln Glu Glu Leu Arg Glu
    1250                1255                1260                
Asp Lys Ala Tyr Gln Leu Glu Arg His Arg Ile Glu Ala Ala Met Asp
1265                1270                1275                1280
Arg Lys Ser Asp Ser Asp Met Trp Ile Asn Gln Ser Ser Ser Leu Asp
                1285                1290                1295    
Ser Ser Thr Ser Ser Gln Glu His Leu Asn His Ser Ser Lys Ser Val
            1300                1305                1310        
Thr Pro Ala Ser Thr Leu Thr Lys Ser Gly Pro Gly Arg Trp Lys Thr
        1315                1320                1325            
Pro Ala Ala Ile Pro Ala Thr Pro Val Ala Val Ser Gln Pro Ile Arg
    1330                1335                1340                
Thr Asp Leu Pro Pro Pro Pro Pro Pro Pro Pro Val His Tyr Ala Gly
1345                1350                1355                1360
Asp Phe Asp Gly Met Ser Met Asp Leu Pro Leu Pro Pro Pro Pro Ser
                1365                1370                1375    
Ala Asn Gln Ile Gly Leu Pro Ser Ala Gln Val Ala Ala Ala Glu Arg
            1380                1385                1390        
Arg Lys Arg Glu Glu His Gln Arg Trp Tyr Glu Lys Glu Lys Ala Arg
        1395                1400                1405            
Leu Glu Glu Glu Arg Glu Arg Lys Arg Arg Glu Gln Glu Arg Lys Leu
    1410                1415                1420                
Gly Gln Met Arg Thr Gln Ser Leu Asn Pro Ala Pro Phe Ser Pro Leu
1425                1430                1435                1440
Thr Ala Gln Gln Met Lys Pro Glu Lys Pro Ser Thr Leu Gln Arg Pro
                1445                1450                1455    
Gln Glu Thr Val Ile Arg Glu Leu Gln Pro Gln Gln Gln Pro Arg Thr
            1460                1465                1470        
Ile Glu Arg Arg Asp Leu Gln Tyr Ile Thr Val Ser Lys Glu Glu Leu
        1475                1480                1485            
Ser Ser Gly Asp Ser Leu Ser Pro Asp Pro Trp Lys Arg Asp Ala Lys
    1490                1495                1500                
Glu Lys Leu Glu Lys Gln Gln Gln Met His Ile Val Asp Met Leu Ser
1505                1510                1515                1520
Lys Glu Ile Gln Glu Leu Gln Ser Lys Pro Asp Arg Ser Ala Glu Glu
                1525                1530                1535    
Ser Asp Arg Leu Arg Lys Leu Met Leu Glu Trp Gln Phe Gln Lys Arg
            1540                1545                1550        
Leu Gln Glu Ser Lys Gln Lys Asp Glu Asp Asp Glu Glu Glu Glu Asp
        1555                1560                1565            
Asp Asp Val Asp Thr Met Leu Ile Met Gln Arg Leu Glu Ala Glu Arg
    1570                1575                1580                
Arg Ala Arg Leu Gln Asp Glu Glu Arg Arg Arg Gln Gln Gln Leu Glu
1585                1590                1595                1600
Glu Met Arg Lys Arg Glu Ala Glu Asp Arg Ala Arg Gln Glu Glu Glu
                1605                1610                1615    
Arg Arg Arg Gln Glu Glu Glu Arg Thr Lys Arg Asp Ala Glu Glu Lys
            1620                1625                1630        
Arg Arg Gln Glu Glu Gly Tyr Tyr Ser Arg Leu Glu Ala Glu Arg Arg
        1635                1640                1645            
Arg Gln His Asp Glu Ala Ala Arg Arg Leu Leu Glu Pro Glu Ala Pro
    1650                1655                1660                
Gly Leu Cys Arg Pro Pro Leu Pro Arg Asp Tyr Glu Pro Pro Ser Pro
1665                1670                1675                1680
Ser Pro Ala Pro Gly Ala Pro Pro Pro Pro Pro Gln Arg Asn Ala Ser
                1685                1690                1695    
Tyr Leu Lys Thr Gln Val Leu Ser Pro Asp Ser Leu Phe Thr Ala Lys
            1700                1705                1710        
Phe Val Ala Tyr Asn Glu Glu Glu Glu Glu Glu Asp Cys Ser Leu Ala
        1715                1720                1725            
Gly Gln Asp Lys Tyr Ser Ser Thr Arg Lys Ser His Gly Asp Leu Leu
    1730                1735                1740                
Pro Ala Pro Leu Lys Pro Arg Pro Pro Pro Cys Gln Pro Arg Pro Ala
1745                1750                1755                1760
Ser Asp Gly Val Phe Leu Ser Asn Ser Phe Gln Pro Pro Ser Ala Lys
                1765                1770                1775    
Ala Asn Ser Thr Ala His Lys Lys Gly Gln Pro Leu Pro Pro Pro Lys
            1780                1785                1790        
Lys Ser Ser Ser Tyr His Pro Ser His Cys Lys Gly Arg Gly Lys Arg
        1795                1800                1805            
Val Thr Asn Gln Leu Ser Leu Ser
    1810                1815    


<210> 1353
<211> 501
<212> PRT
<213> Homo sapiens

<400> 1353
Gly Ala Ser Pro Leu Ala Ser Pro Gly Gly Ser Pro Lys Gly Ser Pro
 1               5                  10                  15      
Ala Arg Ser Leu Ala Arg Pro Gly Thr Pro Leu Pro Ser Pro Gln Ala
            20                  25                  30          
Pro Arg Val Asp Leu Gln Gly Ala Glu Leu Trp Lys Arg Phe His Glu
        35                  40                  45              
Ile Gly Thr Glu Met Ile Ile Thr Lys Ala Gly Arg Arg Met Phe Pro
    50                  55                  60                  
Ala Met Arg Val Lys Ile Ser Gly Leu Asp Pro His Gln Gln Tyr Tyr
65                  70                  75                  80  
Ile Ala Met Asp Ile Val Pro Val Asp Asn Lys Arg Tyr Arg Tyr Val
                85                  90                  95      
Tyr His Ser Ser Lys Trp Met Val Ala Gly Asn Ala Asp Ser Pro Val
            100                 105                 110         
Pro Pro Arg Val Tyr Ile His Pro Asp Ser Pro Ala Ser Gly Glu Thr
        115                 120                 125             
Trp Met Arg Gln Val Ile Ser Phe Asp Lys Leu Lys Leu Thr Asn Asn
    130                 135                 140                 
Glu Leu Asp Asp Gln Gly His Ile Ile Leu His Ser Met His Lys Tyr
145                 150                 155                 160 
Gln Pro Arg Val His Val Ile Arg Lys Asp Cys Gly Asp Asp Leu Ser
                165                 170                 175     
Pro Ile Lys Pro Val Pro Ser Gly Glu Gly Val Lys Ala Phe Ser Phe
            180                 185                 190         
Pro Glu Thr Val Phe Thr Thr Val Thr Ala Tyr Gln Asn Gln Gln Ile
        195                 200                 205             
Thr Arg Leu Lys Ile Asp Arg Asn Pro Phe Ala Lys Gly Phe Arg Asp
    210                 215                 220                 
Ser Gly Arg Asn Arg Met Gly Leu Glu Ala Leu Val Glu Ser Tyr Ala
225                 230                 235                 240 
Phe Trp Arg Pro Ser Leu Arg Thr Leu Thr Phe Glu Asp Ile Pro Gly
                245                 250                 255     
Ile Pro Lys Gln Gly Asn Ala Ser Ser Ser Thr Leu Leu Gln Gly Thr
            260                 265                 270         
Gly Asn Gly Val Pro Ala Thr His Pro His Leu Leu Ser Gly Ser Ser
        275                 280                 285             
Cys Ser Ser Pro Ala Phe His Leu Gly Pro Asn Thr Ser Gln Leu Cys
    290                 295                 300                 
Ser Leu Ala Pro Ala Asp Tyr Ser Ala Cys Ala Arg Ser Gly Leu Thr
305                 310                 315                 320 
Leu Asn Arg Tyr Ser Thr Ser Leu Ala Glu Thr Tyr Asn Arg Leu Thr
                325                 330                 335     
Asn Gln Ala Gly Glu Thr Phe Ala Pro Pro Arg Thr Pro Ser Tyr Val
            340                 345                 350         
Gly Val Ser Ser Ser Thr Ser Val Asn Met Ser Met Gly Gly Thr Asp
        355                 360                 365             
Gly Asp Thr Phe Ser Cys Pro Gln Thr Ser Leu Ser Met Gln Ile Ser
    370                 375                 380                 
Gly Met Ser Pro Gln Leu Gln Tyr Ile Met Pro Ser Pro Ser Ser Asn
385                 390                 395                 400 
Ala Phe Ala Thr Asn Gln Thr His Gln Gly Ser Tyr Asn Thr Phe Arg
                405                 410                 415     
Leu His Ser Pro Cys Ala Leu Tyr Gly Tyr Asn Phe Ser Thr Ser Pro
            420                 425                 430         
Lys Leu Ala Ala Ser Pro Glu Lys Ile Val Ser Ser Gln Gly Ser Phe
        435                 440                 445             
Leu Gly Ser Ser Pro Ser Gly Thr Met Thr Asp Arg Gln Met Leu Pro
    450                 455                 460                 
Pro Val Glu Gly Val His Leu Leu Ser Ser Gly Gly Gln Gln Ser Phe
465                 470                 475                 480 
Phe Asp Ser Arg Thr Leu Gly Ser Leu Thr Leu Ser Ser Ser Gln Val
                485                 490                 495     
Ser Ala His Met Val
            500     


<210> 1354
<211> 953
<212> PRT
<213> Homo sapiens

<400> 1354
Met Thr Ala Ala Glu Asn Val Cys Tyr Thr Leu Ile Asn Val Pro Met
 1               5                  10                  15      
Asp Ser Glu Pro Pro Ser Glu Ile Ser Leu Lys Asn Asp Leu Glu Lys
            20                  25                  30          
Gly Asp Val Lys Ser Lys Thr Glu Ala Leu Lys Lys Val Ile Ile Met
        35                  40                  45              
Ile Leu Asn Gly Glu Lys Leu Pro Gly Leu Leu Met Thr Ile Ile Arg
    50                  55                  60                  
Phe Val Leu Pro Leu Gln Asp His Thr Ile Lys Lys Leu Leu Leu Val
65                  70                  75                  80  
Phe Trp Glu Ile Val Pro Lys Thr Thr Pro Asp Gly Arg Leu Leu His
                85                  90                  95      
Glu Met Ile Leu Val Cys Asp Ala Tyr Arg Lys Asp Leu Gln His Pro
            100                 105                 110         
Asn Glu Phe Ile Arg Gly Ser Thr Leu Arg Phe Leu Cys Lys Leu Lys
        115                 120                 125             
Glu Ala Glu Leu Leu Glu Pro Leu Met Pro Ala Ile Arg Ala Cys Leu
    130                 135                 140                 
Glu His Arg His Ser Tyr Val Arg Arg Asn Ala Val Leu Ala Ile Tyr
145                 150                 155                 160 
Thr Ile Tyr Arg Asn Phe Glu His Leu Ile Pro Asp Ala Pro Glu Leu
                165                 170                 175     
Ile His Asp Phe Leu Val Asn Glu Lys Asp Ala Ser Cys Lys Arg Asn
            180                 185                 190         
Ala Phe Met Met Leu Ile His Ala Asp Gln Asp Arg Ala Leu Asp Tyr
        195                 200                 205             
Leu Ser Thr Cys Ile Asp Gln Val Gln Thr Phe Gly Asp Ile Leu Gln
    210                 215                 220                 
Leu Val Ile Val Glu Leu Ile Tyr Lys Val Cys His Ala Asn Pro Ser
225                 230                 235                 240 
Glu Arg Ala Arg Phe Ile Arg Cys Ile Tyr Asn Leu Leu Gln Ser Ser
                245                 250                 255     
Ser Pro Ala Val Lys Tyr Glu Ala Ala Gly Thr Leu Val Thr Leu Ser
            260                 265                 270         
Ser Ala Pro Thr Ala Ile Lys Ala Ala Ala Gln Cys Tyr Ile Asp Leu
        275                 280                 285             
Ile Ile Lys Glu Ser Asp Asn Asn Val Lys Leu Ile Val Leu Asp Arg
    290                 295                 300                 
Leu Ile Glu Leu Lys Glu His Pro Ala His Glu Arg Val Leu Gln Asp
305                 310                 315                 320 
Leu Val Met Asp Ile Leu Arg Val Leu Ser Thr Pro Asp Leu Glu Val
                325                 330                 335     
Arg Lys Lys Thr Leu Gln Leu Ala Leu Asp Leu Val Ser Ser Arg Asn
            340                 345                 350         
Val Glu Glu Leu Val Ile Val Leu Lys Lys Glu Val Ile Lys Thr Asn
        355                 360                 365             
Asn Val Ser Glu His Glu Asp Thr Asp Lys Tyr Arg Gln Leu Leu Val
    370                 375                 380                 
Arg Thr Leu His Ser Cys Ser Val Arg Phe Pro Asp Met Ala Ala Asn
385                 390                 395                 400 
Val Ile Pro Val Leu Met Glu Phe Leu Ser Asp Asn Asn Glu Ala Ala
                405                 410                 415     
Ala Ala Asp Val Leu Glu Phe Val Arg Glu Ala Ile Gln Arg Phe Asp
            420                 425                 430         
Asn Leu Arg Met Leu Ile Val Glu Lys Met Leu Glu Val Phe His Ala
        435                 440                 445             
Ile Lys Ser Val Lys Ile Tyr Arg Gly Ala Leu Trp Ile Leu Gly Glu
    450                 455                 460                 
Tyr Cys Ser Thr Lys Glu Asp Ile Gln Ser Val Met Thr Glu Ile Arg
465                 470                 475                 480 
Arg Ser Leu Gly Glu Ile Pro Ile Val Glu Ser Glu Ile Lys Lys Glu
                485                 490                 495     
Ala Gly Glu Leu Lys Pro Glu Glu Glu Ile Thr Val Gly Pro Val Gln
            500                 505                 510         
Lys Leu Val Thr Glu Met Gly Thr Tyr Ala Thr Gln Ser Ala Leu Ser
        515                 520                 525             
Ser Ser Arg Pro Thr Lys Lys Glu Glu Asp Arg Pro Pro Leu Arg Gly
    530                 535                 540                 
Phe Leu Leu Asp Gly Asp Phe Phe Val Ala Ala Ser Leu Ala Thr Thr
545                 550                 555                 560 
Leu Thr Lys Ile Ala Leu Arg Tyr Val Ala Leu Val Gln Glu Lys Lys
                565                 570                 575     
Lys Gln Asn Ser Phe Val Ala Glu Ala Met Leu Leu Met Ala Thr Ile
            580                 585                 590         
Leu His Leu Gly Lys Ser Ser Leu Pro Lys Lys Pro Ile Thr Asp Asp
        595                 600                 605             
Asp Val Asp Arg Ile Ser Leu Cys Leu Lys Val Leu Ser Glu Cys Ser
    610                 615                 620                 
Pro Leu Met Asn Asp Ile Phe Asn Lys Glu Cys Arg Gln Ser Leu Ser
625                 630                 635                 640 
His Met Leu Ser Ala Lys Leu Glu Glu Glu Lys Leu Ser Gln Lys Lys
                645                 650                 655     
Glu Ser Glu Lys Arg Asn Val Thr Val Gln Pro Asp Asp Pro Ile Ser
            660                 665                 670         
Phe Met Gln Leu Thr Ala Lys Asn Glu Met Asn Cys Lys Glu Asp Gln
        675                 680                 685             
Phe Gln Leu Ser Leu Leu Ala Ala Met Gly Asn Thr Gln Arg Lys Glu
    690                 695                 700                 
Ala Ala Asp Pro Leu Ala Ser Lys Leu Asn Lys Val Thr Gln Leu Thr
705                 710                 715                 720 
Gly Phe Ser Asp Pro Val Tyr Ala Glu Ala Tyr Val His Val Asn Gln
                725                 730                 735     
Tyr Asp Ile Val Leu Asp Val Leu Val Val Asn Gln Thr Ser Asp Thr
            740                 745                 750         
Leu Gln Asn Cys Thr Leu Glu Leu Ala Thr Leu Gly Asp Leu Lys Leu
        755                 760                 765             
Val Glu Lys Pro Ser Pro Leu Thr Leu Ala Pro His Asp Phe Ala Asn
    770                 775                 780                 
Ile Lys Ala Asn Val Lys Val Ala Ser Thr Glu Asn Gly Ile Ile Phe
785                 790                 795                 800 
Gly Asn Ile Val Tyr Asp Val Ser Gly Ala Ala Ser Asp Arg Asn Cys
                805                 810                 815     
Val Val Leu Ser Asp Ile His Ile Glu Ile Met Asp Tyr Ile Gln Pro
            820                 825                 830         
Ala Thr Cys Thr Asp Ala Glu Phe Arg Gln Met Trp Ala Glu Leu Glu
        835                 840                 845             
Trp Glu Asn Lys Val Thr Val Asn Thr Asn Met Val Asp Leu Asn Asp
    850                 855                 860                 
Tyr Leu Gln His Ile Leu Lys Ser Thr Asn Met Lys Cys Leu Thr Pro
865                 870                 875                 880 
Glu Lys Ala Leu Ser Gly Tyr Cys Gly Phe Met Ala Ala Asn Leu Tyr
                885                 890                 895     
Ala Arg Ser Ile Phe Gly Glu Asp Ala Leu Ala Asn Val Ser Ser Glu
            900                 905                 910         
Lys Pro Leu His Gln Gly Pro Asp Ala Ala Val Thr Val His Ile Arg
        915                 920                 925             
Ile Arg Ala Lys Ser Gln Gly Met Ala Leu Ser Leu Gly Asp Lys Ile
    930                 935                 940                 
Asn Leu Ser Gln Lys Glu Thr Ser Ile
945                 950             


<210> 1355
<211> 803
<212> PRT
<213> Homo sapiens

<400> 1355
Met Glu Ile Pro Lys Leu Leu Pro Ala Arg Gly Thr Leu Gln Gly Gly
 1               5                  10                  15      
Gly Gly Gly Gly Ile Pro Ala Gly Gly Gly Arg Val His Arg Gly Pro
            20                  25                  30          
Asp Ser Pro Ala Gly Gln Val Pro Thr Arg Arg Leu Leu Leu Leu Arg
        35                  40                  45              
Gly Pro Gln Asp Gly Gly Pro Gly Arg Arg Arg Glu Glu Ala Ser Thr
    50                  55                  60                  
Ala Ser Arg Gly Pro Gly Pro Ser Leu Leu Ala Pro Arg Thr Asp Gln
65                  70                  75                  80  
Pro Ser Gly Gly Gly Gly Gly Gly Gly Asp Asp Phe Phe Leu Val Leu
                85                  90                  95      
Leu Asp Pro Val Gly Gly Asp Val Glu Thr Ala Gly Ser Gly Gln Ala
            100                 105                 110         
Ala Gly Pro Val Leu Arg Glu Glu Ala Glu Glu Gly Pro Gly Leu Gln
        115                 120                 125             
Gly Gly Glu Ser Gly Ala Asn Pro Ala Gly Pro Thr Ala Leu Gly Pro
    130                 135                 140                 
Arg Cys Leu Ser Ala Val Pro Thr Pro Ala Pro Ile Ser Ala Pro Gly
145                 150                 155                 160 
Pro Ala Ala Ala Phe Ala Gly Thr Val Thr Ile His Asn Gln Asp Leu
                165                 170                 175     
Leu Leu Arg Phe Glu Asn Gly Val Leu Thr Leu Ala Thr Pro Pro Pro
            180                 185                 190         
His Ala Trp Glu Pro Gly Ala Ala Pro Ala Gln Gln Pro Gly Cys Leu
        195                 200                 205             
Ile Ala Pro Gln Ala Gly Phe Pro His Ala Ala His Pro Gly Asp Cys
    210                 215                 220                 
Pro Glu Leu Pro Pro Asp Leu Leu Leu Ala Glu Pro Ala Glu Pro Ala
225                 230                 235                 240 
Pro Ala Pro Ala Pro Glu Glu Glu Ala Glu Gly Pro Ala Ala Ala Leu
                245                 250                 255     
Gly Pro Arg Gly Pro Leu Gly Ser Gly Pro Gly Val Val Leu Tyr Leu
            260                 265                 270         
Cys Pro Glu Ala Gln Cys Gly Gln Thr Phe Ala Lys Lys His Gln Leu
        275                 280                 285             
Lys Val His Leu Leu Thr His Ser Ser Ser Gln Gly Gln Arg Pro Phe
    290                 295                 300                 
Lys Cys Pro Leu Gly Gly Cys Gly Trp Thr Phe Thr Thr Ser Tyr Lys
305                 310                 315                 320 
Leu Lys Arg His Leu Gln Ser His Asp Lys Leu Arg Pro Phe Gly Cys
                325                 330                 335     
Pro Ala Glu Gly Cys Gly Lys Ser Phe Thr Thr Val Tyr Asn Leu Lys
            340                 345                 350         
Ala His Met Lys Gly His Glu Gln Glu Asn Ser Phe Lys Cys Glu Val
        355                 360                 365             
Cys Glu Glu Ser Phe Pro Thr Gln Ala Lys Leu Ser Ala His Gln Arg
    370                 375                 380                 
Ser His Phe Glu Pro Glu Arg Pro Tyr Gln Cys Ala Phe Ser Gly Cys
385                 390                 395                 400 
Lys Lys Thr Phe Ile Thr Val Ser Ala Leu Phe Ser His Asn Arg Ala
                405                 410                 415     
His Phe Arg Glu Gln Glu Leu Phe Ser Cys Ser Phe Pro Gly Cys Ser
            420                 425                 430         
Lys Gln Tyr Asp Lys Ala Cys Arg Leu Lys Ile His Leu Arg Ser His
        435                 440                 445             
Thr Gly Glu Arg Pro Phe Leu Cys Asp Phe Asp Gly Cys Gly Trp Asn
    450                 455                 460                 
Phe Thr Ser Met Ser Lys Leu Leu Arg His Lys Arg Lys His Asp Asp
465                 470                 475                 480 
Asp Arg Arg Phe Met Cys Pro Val Glu Gly Cys Gly Lys Ser Phe Thr
                485                 490                 495     
Arg Ala Glu His Leu Lys Gly His Ser Ile Thr His Leu Gly Thr Lys
            500                 505                 510         
Pro Phe Val Cys Pro Val Ala Gly Cys Cys Ala Arg Phe Ser Ala Arg
        515                 520                 525             
Ser Ser Leu Tyr Ile His Ser Lys Lys His Leu Gln Asp Val Asp Thr
    530                 535                 540                 
Trp Lys Ser Arg Cys Pro Ile Ser Ser Cys Asn Lys Leu Phe Thr Ser
545                 550                 555                 560 
Lys His Ser Met Lys Thr His Met Val Lys Arg His Lys Val Gly Gln
                565                 570                 575     
Asp Leu Leu Ala Gln Leu Glu Ala Ala Asn Ser Leu Thr Pro Ser Ser
            580                 585                 590         
Glu Leu Thr Ser Gln Arg Gln Asn Asp Leu Ser Asp Ala Glu Ile Val
        595                 600                 605             
Ser Leu Phe Ser Asp Val Pro Asp Ser Thr Ser Ala Ala Leu Leu Asp
    610                 615                 620                 
Thr Ala Leu Val Asn Ser Gly Ile Leu Thr Ile Asp Val Ala Ser Val
625                 630                 635                 640 
Ser Ser Thr Leu Ala Gly His Leu Pro Ala Asn Asn Asn Asn Ser Val
                645                 650                 655     
Gly Gln Ala Val Asp Pro Pro Ser Leu Met Ala Thr Ser Asp Pro Pro
            660                 665                 670         
Gln Ser Leu Asp Thr Ser Leu Phe Phe Gly Thr Ala Ala Thr Gly Phe
        675                 680                 685             
Gln Gln Ser Ser Leu Asn Met Asp Glu Val Ser Ser Val Ser Val Gly
    690                 695                 700                 
Pro Leu Gly Ser Leu Asp Ser Leu Ala Met Lys Asn Ser Ser Pro Glu
705                 710                 715                 720 
Pro Gln Ala Leu Thr Pro Ser Ser Lys Leu Thr Val Asp Thr Asp Ala
                725                 730                 735     
Leu Thr Pro Ser Ser Thr Leu Cys Glu Asn Ser Val Ser Glu Leu Leu
            740                 745                 750         
Thr Pro Thr Lys Ala Glu Trp Asn Val His Pro Asp Ser Asp Phe Phe
        755                 760                 765             
Gly Gln Glu Gly Glu Thr Gln Phe Gly Phe Pro Asn Ala Ala Gly Asn
    770                 775                 780                 
His Gly Ser Gln Lys Glu Thr Asp Leu Ile Thr Val Thr Gly Ser Ser
785                 790                 795                 800 
Phe Leu Val
            


<210> 1356
<211> 731
<212> PRT
<213> Homo sapiens

<400> 1356
Met Val Lys Pro Lys Tyr Lys Gly Arg Ser Thr Ile Asn Pro Ser Lys
 1               5                  10                  15      
Ala Ser Thr Asn Pro Asp Arg Val Gln Gly Ala Gly Gly Gln Asn Met
            20                  25                  30          
Arg Asp Arg Ala Thr Ile Arg Arg Leu Asn Met Tyr Arg Gln Lys Glu
        35                  40                  45              
Arg Arg Asn Ser Arg Gly Lys Ile Ile Lys Pro Leu Gln Tyr Gln Ser
    50                  55                  60                  
Thr Val Ala Ser Gly Thr Val Ala Arg Val Glu Pro Asn Ile Lys Trp
65                  70                  75                  80  
Phe Gly Asn Thr Arg Val Ile Lys Gln Ser Ser Leu Gln Lys Phe Gln
                85                  90                  95      
Glu Glu Met Asp Thr Val Met Lys Asp Pro Tyr Lys Val Val Met Lys
            100                 105                 110         
Gln Ser Lys Leu Pro Met Ser Leu Leu His Asp Arg Ile Arg Pro His
        115                 120                 125             
Asn Leu Lys Val His Ile Leu Asp Thr Glu Ser Phe Glu Thr Thr Phe
    130                 135                 140                 
Gly Pro Lys Ser Gln Arg Lys Arg Pro Asn Leu Phe Ala Ser Asp Met
145                 150                 155                 160 
Gln Ser Leu Ile Glu Asn Ala Glu Met Ser Thr Glu Ser Tyr Asp Gln
                165                 170                 175     
Gly Lys Asp Arg Asp Leu Val Thr Glu Asp Thr Gly Val Arg Asn Glu
            180                 185                 190         
Ala Gln Glu Glu Ile Tyr Lys Lys Gly Gln Ser Lys Arg Ile Trp Gly
        195                 200                 205             
Glu Leu Tyr Lys Val Ile Asp Ser Ser Asp Val Val Val Gln Val Leu
    210                 215                 220                 
Asp Ala Arg Asp Pro Met Gly Thr Arg Ser Pro His Ile Glu Thr Tyr
225                 230                 235                 240 
Leu Lys Lys Glu Lys Pro Trp Lys His Leu Ile Phe Val Leu Asn Lys
                245                 250                 255     
Cys Asp Leu Val Pro Thr Trp Ala Thr Lys Arg Trp Val Ala Val Leu
            260                 265                 270         
Ser Gln Asp Tyr Pro Thr Leu Ala Phe His Ala Ile Leu Thr Asn Pro
        275                 280                 285             
Phe Gly Lys Gly Ala Phe Ile Gln Leu Leu Arg Gln Phe Gly Lys Leu
    290                 295                 300                 
His Thr Asp Lys Lys Gln Ile Ser Val Gly Phe Ile Gly Tyr Pro Asn
305                 310                 315                 320 
Val Gly Lys Ser Ser Val Ile Asn Thr Leu Arg Ser Lys Lys Val Cys
                325                 330                 335     
Asn Val Ala Pro Ile Ala Gly Glu Thr Lys Val Trp Gln Tyr Ile Thr
            340                 345                 350         
Leu Met Arg Arg Ile Phe Leu Ile Asp Cys Pro Gly Val Val Tyr Pro
        355                 360                 365             
Ser Glu Asp Ser Glu Thr Asp Ile Val Leu Lys Gly Val Val Gln Val
    370                 375                 380                 
Glu Lys Ile Lys Ser Pro Glu Asp His Ile Gly Ala Val Leu Glu Arg
385                 390                 395                 400 
Ala Lys Pro Glu Tyr Ile Ser Lys Thr Tyr Lys Ile Asp Ser Trp Glu
                405                 410                 415     
Asn Ala Glu Asp Phe Leu Glu Lys Leu Ala Phe Arg Thr Gly Lys Leu
            420                 425                 430         
Leu Lys Gly Gly Glu Pro Asp Leu Gln Thr Val Gly Lys Met Val Leu
        435                 440                 445             
Asn Asp Trp Gln Arg Gly Arg Ile Pro Phe Phe Val Lys Pro Pro Asn
    450                 455                 460                 
Ala Glu Pro Leu Val Ala Pro Gln Leu Leu Pro Ser Ser Ser Leu Glu
465                 470                 475                 480 
Val Val Pro Glu Ala Ala Gln Asn Asn Pro Gly Glu Glu Val Thr Glu
                485                 490                 495     
Thr Ala Gly Glu Gly Ser Glu Ser Ile Ile Lys Glu Glu Thr Glu Glu
            500                 505                 510         
Asn Ser His Cys Asp Ala Asn Thr Glu Met Gln Gln Ile Leu Thr Arg
        515                 520                 525             
Val Arg Gln Asn Phe Gly Lys Ile Asn Val Val Pro Gln Phe Ser Gly
    530                 535                 540                 
Asp Asp Leu Val Pro Val Glu Val Ser Asp Leu Glu Glu Glu Leu Glu
545                 550                 555                 560 
Ser Phe Ser Asp Glu Glu Glu Glu Glu Gln Glu Gln Gln Arg Asp Asp
                565                 570                 575     
Ala Glu Glu Ser Ser Ser Glu Pro Glu Glu Glu Asn Val Gly Asn Asp
            580                 585                 590         
Thr Lys Ala Val Ile Lys Ala Leu Asp Glu Lys Ile Ala Lys Tyr Gln
        595                 600                 605             
Lys Phe Leu Asp Lys Ala Lys Ala Lys Lys Phe Ser Ala Val Arg Ile
    610                 615                 620                 
Ser Lys Gly Leu Ser Glu Lys Ile Phe Ala Lys Pro Glu Glu Gln Arg
625                 630                 635                 640 
Lys Thr Leu Glu Glu Asp Val Asp Asp Arg Ala Pro Ser Lys Lys Gly
                645                 650                 655     
Lys Lys Arg Lys Ala Gln Arg Glu Glu Glu Gln Glu His Ser Asn Lys
            660                 665                 670         
Ala Pro Arg Ala Leu Thr Ser Lys Glu Arg Arg Arg Ala Val Arg Gln
        675                 680                 685             
Gln Arg Pro Lys Lys Val Gly Val Arg Tyr Tyr Glu Thr His Asn Val
    690                 695                 700                 
Lys Asn Arg Asn Arg Asn Lys Lys Lys Thr Asn Asp Ser Glu Gly Gln
705                 710                 715                 720 
Lys His Lys Arg Lys Lys Phe Arg Gln Lys Gln
                725                 730     


<210> 1357
<211> 574
<212> PRT
<213> Homo sapiens

<400> 1357
Met Val Asp Asp Glu Glu Leu Ala Gln His Pro Ala Thr Thr Glu Asp
 1               5                  10                  15      
Ile Arg Val Cys Cys Gln Asp Ile Arg Val Leu Gly Arg Lys Glu Leu
            20                  25                  30          
Arg Ser Leu Leu Asn Trp Arg Thr Lys Leu Arg Arg Tyr Val Ala Lys
        35                  40                  45              
Lys Leu Lys Glu Gln Ala Lys Ala Leu Asp Ile Ser Leu Ser Ser Gly
    50                  55                  60                  
Glu Glu Asp Glu Gly Asp Glu Glu Asp Ser Thr Ala Gly Thr Thr Lys
65                  70                  75                  80  
Gln Pro Ser Lys Glu Glu Glu Glu Glu Glu Glu Glu Glu Gln Leu Asn
                85                  90                  95      
Gln Thr Leu Ala Glu Met Lys Ala Gln Glu Val Ala Glu Leu Lys Arg
            100                 105                 110         
Lys Lys Lys Lys Leu Leu Arg Glu Gln Arg Lys Gln Arg Glu Arg Val
        115                 120                 125             
Glu Leu Lys Met Asp Leu Pro Gly Val Ser Ile Ala Asp Glu Gly Glu
    130                 135                 140                 
Thr Gly Met Phe Ser Leu Cys Thr Ile Arg Gly His Gln Leu Leu Glu
145                 150                 155                 160 
Glu Val Thr Gln Gly Asp Met Ser Ala Ala Asp Thr Phe Leu Ser Asp
                165                 170                 175     
Leu Pro Arg Asp Asp Ile Tyr Val Ser Asp Val Glu Asp Asp Gly Asp
            180                 185                 190         
Asp Thr Ser Leu Asp Ser Asp Leu Asp Pro Glu Glu Leu Ala Gly Val
        195                 200                 205             
Arg Gly His Gln Gly Leu Arg Asp Gln Lys Arg Met Arg Leu Thr Glu
    210                 215                 220                 
Val Gln Asp Asp Lys Glu Glu Glu Glu Glu Glu Asn Pro Leu Leu Val
225                 230                 235                 240 
Pro Leu Glu Glu Lys Ala Val Leu Gln Glu Glu Gln Ala Asn Leu Trp
                245                 250                 255     
Phe Ser Lys Gly Ser Phe Ala Gly Ile Glu Asp Asp Ala Asp Glu Ala
            260                 265                 270         
Leu Glu Ile Ser Gln Ala Gln Leu Leu Phe Glu Asn Arg Arg Lys Gly
        275                 280                 285             
Arg Gln Gln Gln Gln Lys Gln Gln Leu Pro Gln Thr Pro Pro Ser Cys
    290                 295                 300                 
Leu Lys Thr Glu Ile Met Ser Pro Leu Tyr Gln Asp Glu Ala Pro Lys
305                 310                 315                 320 
Gly Thr Glu Ala Ser Ser Gly Thr Glu Ala Ala Thr Gly Leu Glu Gly
                325                 330                 335     
Glu Glu Lys Asp Gly Ile Ser Asp Ser Asp Ser Ser Thr Ser Ser Glu
            340                 345                 350         
Glu Glu Glu Ser Trp Glu Pro Leu Arg Gly Lys Lys Arg Ser Arg Gly
        355                 360                 365             
Pro Lys Ser Asp Asp Asp Gly Phe Glu Ile Val Pro Ile Glu Asp Pro
    370                 375                 380                 
Ala Lys His Arg Ile Leu Asp Pro Glu Gly Leu Ala Leu Gly Ala Val
385                 390                 395                 400 
Ile Ala Ser Ser Lys Lys Ala Lys Arg Asp Leu Ile Asp Asn Ser Phe
                405                 410                 415     
Asn Arg Tyr Thr Phe Asn Glu Asp Glu Gly Glu Leu Pro Glu Trp Phe
            420                 425                 430         
Val Gln Glu Glu Lys Gln His Arg Ile Arg Gln Leu Pro Val Gly Lys
        435                 440                 445             
Lys Glu Val Glu His Tyr Arg Lys Arg Trp Arg Glu Ile Asn Ala Arg
    450                 455                 460                 
Pro Ile Lys Lys Val Ala Glu Ala Lys Ala Arg Lys Lys Arg Arg Met
465                 470                 475                 480 
Leu Lys Arg Leu Glu Gln Thr Arg Lys Lys Ala Glu Ala Val Val Asn
                485                 490                 495     
Thr Val Asp Ile Ser Glu Arg Glu Lys Val Ala Gln Leu Arg Ser Leu
            500                 505                 510         
Tyr Lys Lys Ala Gly Leu Gly Lys Glu Lys Arg His Val Thr Tyr Val
        515                 520                 525             
Val Ala Lys Lys Gly Val Gly Arg Lys Val Arg Arg Pro Ala Gly Val
    530                 535                 540                 
Arg Gly His Phe Lys Val Val Asp Ser Arg Met Lys Lys Asp Gln Arg
545                 550                 555                 560 
Ala Gln Gln Arg Lys Glu Gln Lys Lys Lys His Lys Arg Lys
                565                 570                 


<210> 1358
<211> 647
<212> PRT
<213> Homo sapiens

<400> 1358
Met Ala Arg Ala Gly Pro Arg Leu Val Leu Ser Glu Glu Ala Val Arg
 1               5                  10                  15      
Ala Lys Ser Gly Leu Gly Pro His Arg Asp Leu Ala Glu Leu Gln Ser
            20                  25                  30          
Leu Ser Ile Pro Gly Thr Tyr Gln Glu Lys Ile Thr His Leu Gly His
        35                  40                  45              
Ser Leu Met Ser Leu Thr Gly Leu Lys Ser Leu Asp Leu Ser Arg Asn
    50                  55                  60                  
Ser Leu Val Ser Leu Glu Gly Ile Gln Tyr Leu Thr Ala Leu Glu Ser
65                  70                  75                  80  
Leu Asn Leu Tyr Tyr Asn Cys Ile Ser Ser Leu Ala Glu Val Phe Arg
                85                  90                  95      
Leu His Ala Leu Thr Glu Leu Val Asp Val Asp Phe Arg Leu Asn Pro
            100                 105                 110         
Val Val Lys Val Glu Pro Asp Tyr Arg Leu Phe Val Val His Leu Leu
        115                 120                 125             
Pro Lys Leu Gln Gln Leu Asp Asp Arg Pro Val Arg Ala Ser Glu Arg
    130                 135                 140                 
Lys Ala Ser Arg Leu His Phe Ala Ser Glu Asp Ser Leu Asp Ser Lys
145                 150                 155                 160 
Glu Ser Val Pro Ala Ser Leu Lys Glu Gly Arg Pro His His Pro Arg
                165                 170                 175     
Ala Lys Cys Thr Glu Ala Leu Ala Lys Gln Ser Leu Val Met Asp Ala
            180                 185                 190         
Asp Asp Glu Ala Val Leu Asn Leu Ile Ala Glu Cys Glu Trp Asp Leu
        195                 200                 205             
Gly Arg Pro Pro Gly Ser Thr Ser Phe Ser Gln Lys Gly Arg Glu Ala
    210                 215                 220                 
Asp Ser Arg Gly Ser Gln Glu Ser Arg His Leu Leu Ser Pro Gln Leu
225                 230                 235                 240 
Val Gln Tyr Gln Cys Gly Asp Ser Gly Lys Gln Gly Arg Glu Thr Arg
                245                 250                 255     
Arg Ser Ser Cys Arg Gly Cys Cys Leu Glu Lys Met Pro Trp Ser Gln
            260                 265                 270         
Leu Cys Gly Glu Leu Pro Pro Leu Tyr Gly Ala Glu Pro Glu Ala Ser
        275                 280                 285             
Arg Ala Pro Arg Pro His Thr Tyr Phe Thr Pro His Pro Asp Ser Met
    290                 295                 300                 
Asp Thr Glu Asp Ser Ala Ser Ser Gln Lys Leu Asp Leu Ser Gly Glu
305                 310                 315                 320 
Met Val Pro Gly Pro Leu Pro Ala Pro Gly Lys Cys Arg Lys Arg Arg
                325                 330                 335     
Met Pro Val Gly Arg Phe Gln Thr Phe Ser Asp Gln Glu Gly Leu Gly
            340                 345                 350         
Cys Pro Glu Arg Thr His Gly Ser Ser Val Pro Lys Glu Ser Leu Ser
        355                 360                 365             
Arg Gln Asp Ser Ser Glu Ser Arg Asn Gly Arg Thr Leu Ser Gln Pro
    370                 375                 380                 
Glu Ala Ser Glu Thr Glu Glu Gln Arg Ser Arg Gly Val Thr Asp Thr
385                 390                 395                 400 
Arg Glu Pro Ser Pro Gly Ser His Ser Ala Leu Pro Gly Lys Lys Thr
                405                 410                 415     
Ala Leu Gln Ala Ala Leu Leu Glu Thr Leu Leu Asp Leu Val Asp Arg
            420                 425                 430         
Ser Trp Gly Gly Cys Arg Ser Leu His Ser Asn Glu Ala Phe Leu Ala
        435                 440                 445             
Gln Ala Arg His Ile Leu Ser Ser Val Glu Glu Phe Thr Ala Ala Gln
    450                 455                 460                 
Asp Ser Ser Ala Met Val Gly Glu Asp Val Gly Ser Leu Ala Leu Glu
465                 470                 475                 480 
Ser Lys Ser Leu Gln Ser Arg Leu Ala Glu Gln Gln Gln Gln His Ala
                485                 490                 495     
Arg Glu Met Ser Glu Val Thr Ala Glu Leu His His Thr His Lys Glu
            500                 505                 510         
Leu Asp Asp Leu Arg Gln His Leu Asp Lys Ser Leu Glu Glu Asn Ser
        515                 520                 525             
Arg Leu Lys Ser Leu Leu Leu Ser Met Lys Lys Glu Val Lys Ser Ala
    530                 535                 540                 
Asp Thr Ala Ala Thr Leu Asn Leu Gln Ile Ala Gly Leu Gln Thr Ser
545                 550                 555                 560 
Val Lys Arg Leu Cys Gly Glu Ile Val Glu Leu Lys Gln His Leu Glu
                565                 570                 575     
His Tyr Asp Lys Ile Gln Glu Leu Thr Gln Met Leu Gln Glu Ser His
            580                 585                 590         
Ser Ser Leu Val Ser Thr Asn Glu His Leu Leu Gln Glu Leu Ser Gln
        595                 600                 605             
Val Arg Ala Gln His Arg Ala Glu Val Glu Gln Met His Trp Ser Tyr
    610                 615                 620                 
Gln Glu Leu Lys Lys Thr Met Ala Leu Phe Pro His Ser Ser Ala Ser
625                 630                 635                 640 
His Gly Gly Cys Gln Ala Cys
                645         


<210> 1359
<211> 555
<212> PRT
<213> Homo sapiens

<400> 1359
Pro Arg Val Arg Ala His Ser Ala Ala Met Glu Gln Arg Arg Val Thr
 1               5                  10                  15      
Asp Phe Phe Ala Arg Arg Arg Pro Gly Pro Pro Arg Ile Ala Pro Pro
            20                  25                  30          
Lys Leu Ala Cys Arg Thr Pro Ser Pro Ala Arg Pro Ala Leu Arg Ala
        35                  40                  45              
Pro Ala Ser Ala Thr Ser Gly Ser Arg Lys Arg Ala Arg Pro Pro Ala
    50                  55                  60                  
Ala Pro Gly Arg Asp Gln Ala Arg Pro Pro Ala Arg Arg Arg Leu Arg
65                  70                  75                  80  
Leu Ser Val Asp Glu Val Ser Ser Pro Ser Thr Pro Glu Ala Pro Asp
                85                  90                  95      
Ile Pro Ala Cys Pro Ser Pro Gly Gln Lys Ile Lys Lys Ser Thr Pro
            100                 105                 110         
Ala Ala Gly Gln Pro Pro His Leu Thr Ser Ala Gln Asp Gln Asp Thr
        115                 120                 125             
Ile Ser Glu Leu Ala Ser Cys Leu Gln Arg Ala Arg Glu Leu Gly Ala
    130                 135                 140                 
Arg Val Arg Ala Leu Lys Ala Ser Ala Gln Asp Ala Gly Glu Ser Cys
145                 150                 155                 160 
Thr Pro Glu Ala Glu Gly Arg Pro Glu Glu Pro Cys Gly Glu Lys Ala
                165                 170                 175     
Pro Ala Tyr Gln Arg Phe His Ala Leu Ala Gln Pro Gly Leu Pro Gly
            180                 185                 190         
Leu Val Leu Pro Tyr Lys Tyr Gln Val Leu Ala Glu Met Phe Arg Ser
        195                 200                 205             
Met Asp Thr Ile Val Gly Met Leu His Asn Arg Ser Glu Thr Pro Thr
    210                 215                 220                 
Phe Ala Lys Val Gln Arg Gly Val Gln Asp Met Met Arg Arg Arg Phe
225                 230                 235                 240 
Glu Glu Arg Asn Val Gly Gln Ile Lys Thr Val Tyr Pro Ala Ser Tyr
                245                 250                 255     
Arg Phe Arg Gln Glu Arg Ser Val Pro Thr Phe Lys Asp Gly Thr Arg
            260                 265                 270         
Arg Ser Asp Tyr Gln Leu Thr Ile Glu Pro Leu Leu Glu Gln Glu Ala
        275                 280                 285             
Asp Gly Ala Ala Pro Gln Leu Thr Ala Ser Arg Leu Leu Gln Arg Arg
    290                 295                 300                 
Gln Ile Phe Ser Gln Lys Leu Val Glu His Val Lys Glu His His Lys
305                 310                 315                 320 
Ala Phe Leu Ala Ser Leu Ser Pro Ala Met Val Val Pro Glu Asp Gln
                325                 330                 335     
Leu Thr Arg Trp His Pro Arg Phe Asn Val Asp Glu Val Pro Asp Ile
            340                 345                 350         
Glu Pro Ala Ala Leu Pro Gln Pro Pro Ala Thr Glu Lys Leu Thr Thr
        355                 360                 365             
Ala Gln Glu Val Leu Ala Arg Ala Arg Asn Leu Ile Ser Pro Arg Met
    370                 375                 380                 
Glu Lys Ala Leu Ser Gln Leu Ala Leu Arg Ser Ala Ala Pro Ser Ser
385                 390                 395                 400 
Pro Gly Ser Pro Arg Pro Ala Leu Pro Ala Thr Pro Pro Ala Thr Pro
                405                 410                 415     
Pro Ala Ala Ser Pro Ser Ala Leu Lys Gly Val Ser Gln Asp Leu Leu
            420                 425                 430         
Glu Arg Ile Arg Ala Lys Glu Ala Gln Lys Gln Leu Ala Gln Met Thr
        435                 440                 445             
Arg Cys Pro Glu Gln Glu Gln Arg Leu Gln Arg Leu Glu Arg Leu Pro
    450                 455                 460                 
Glu Leu Ala Arg Val Leu Arg Ser Val Phe Val Ser Glu Arg Lys Pro
465                 470                 475                 480 
Ala Leu Ser Met Glu Val Ala Cys Ala Arg Met Val Gly Ser Cys Cys
                485                 490                 495     
Thr Ile Met Ser Pro Gly Glu Met Glu Lys His Leu Leu Leu Leu Ser
            500                 505                 510         
Glu Leu Leu Pro Asp Trp Leu Ser Leu His Arg Ile Arg Thr Asp Thr
        515                 520                 525             
Tyr Val Lys Leu Asp Lys Ala Ala Asp Leu Ala His Ile Thr Ala Arg
    530                 535                 540                 
Leu Ala His Gln Thr Arg Ala Glu Glu Gly Leu
545                 550                 555 


<210> 1360
<211> 433
<212> PRT
<213> Homo sapiens

<400> 1360
Met Ser Gly Arg Pro Arg Thr Thr Ser Phe Ala Glu Ser Cys Lys Pro
 1               5                  10                  15      
Val Gln Gln Pro Ser Ala Phe Gly Ser Met Lys Val Ser Arg Asp Lys
            20                  25                  30          
Asp Gly Ser Lys Val Thr Thr Val Val Ala Thr Pro Gly Gln Gly Pro
        35                  40                  45              
Asp Arg Pro Gln Glu Val Ser Tyr Thr Asp Thr Lys Val Ile Gly Asn
    50                  55                  60                  
Gly Ser Phe Gly Val Val Tyr Gln Ala Lys Leu Cys Asp Ser Gly Glu
65                  70                  75                  80  
Leu Val Ala Ile Lys Lys Val Leu Gln Asp Lys Arg Phe Lys Asn Arg
                85                  90                  95      
Glu Leu Gln Ile Met Arg Lys Leu Asp His Cys Asn Ile Val Arg Leu
            100                 105                 110         
Arg Tyr Phe Phe Tyr Ser Ser Gly Glu Lys Lys Asp Glu Val Tyr Leu
        115                 120                 125             
Asn Leu Val Leu Asp Tyr Val Pro Glu Thr Val Tyr Arg Val Ala Arg
    130                 135                 140                 
His Tyr Ser Arg Ala Lys Gln Thr Leu Pro Val Ile Tyr Val Lys Leu
145                 150                 155                 160 
Tyr Met Tyr Gln Leu Phe Arg Ser Leu Ala Tyr Ile His Ser Phe Gly
                165                 170                 175     
Ile Cys His Arg Asp Ile Lys Pro Gln Asn Leu Leu Leu Asp Pro Asp
            180                 185                 190         
Thr Ala Val Leu Lys Leu Cys Asp Phe Gly Ser Ala Lys Gln Leu Val
        195                 200                 205             
Arg Gly Glu Pro Asn Val Ser Tyr Ile Cys Ser Arg Tyr Tyr Arg Ala
    210                 215                 220                 
Pro Glu Leu Ile Phe Gly Ala Thr Asp Tyr Thr Ser Ser Ile Asp Val
225                 230                 235                 240 
Trp Ser Ala Gly Cys Val Leu Ala Glu Leu Leu Leu Gly Gln Pro Ile
                245                 250                 255     
Phe Pro Gly Asp Ser Gly Val Asp Gln Leu Val Glu Ile Ile Lys Val
            260                 265                 270         
Leu Gly Thr Pro Thr Arg Glu Gln Ile Arg Glu Met Asn Pro Asn Tyr
        275                 280                 285             
Thr Glu Phe Lys Phe Pro Gln Ile Lys Ala His Pro Trp Thr Lys Asp
    290                 295                 300                 
Ser Ser Gly Thr Gly His Phe Thr Ser Gly Val Arg Val Phe Arg Pro
305                 310                 315                 320 
Arg Thr Pro Pro Glu Ala Ile Ala Leu Cys Ser Arg Leu Leu Glu Tyr
                325                 330                 335     
Thr Pro Thr Ala Arg Leu Thr Pro Leu Glu Ala Cys Ala His Ser Phe
            340                 345                 350         
Phe Asp Glu Leu Arg Asp Pro Asn Val Lys Leu Pro Asn Gly Arg Asp
        355                 360                 365             
Thr Pro Ala Leu Phe Asn Phe Thr Thr Gln Glu Leu Ser Ser Asn Pro
    370                 375                 380                 
Pro Leu Ala Thr Ile Leu Ile Pro Pro His Ala Arg Ile Gln Ala Ala
385                 390                 395                 400 
Ala Ser Thr Pro Thr Asn Ala Thr Ala Ala Ser Asp Ala Asn Thr Gly
                405                 410                 415     
Asp Arg Gly Gln Thr Asn Asn Ala Ala Ser Ala Ser Ala Ser Asn Ser
            420                 425                 430         
Thr
    


<210> 1361
<211> 151
<212> PRT
<213> Homo sapiens

<400> 1361
Met Ala Ala Ser Ser Gln Gly Asn Phe Glu Gly Asn Phe Glu Ser Leu
 1               5                  10                  15      
Asp Leu Ala Glu Phe Ala Lys Lys Gln Pro Trp Trp Arg Lys Leu Phe
            20                  25                  30          
Gly Gln Glu Ser Gly Pro Ser Ala Glu Lys Tyr Ser Val Ala Thr Gln
        35                  40                  45              
Leu Phe Ile Gly Gly Val Thr Gly Trp Cys Thr Gly Phe Ile Phe Gln
    50                  55                  60                  
Lys Val Gly Lys Leu Ala Ala Thr Ala Val Gly Gly Gly Phe Phe Leu
65                  70                  75                  80  
Leu Gln Leu Ala Asn His Thr Gly Tyr Ile Lys Val Asp Trp Gln Arg
                85                  90                  95      
Val Glu Lys Asp Met Lys Lys Ala Lys Glu Gln Leu Lys Ile Arg Lys
            100                 105                 110         
Ser Asn Gln Ile Pro Thr Glu Val Arg Ser Lys Ala Glu Glu Val Val
        115                 120                 125             
Ser Phe Val Lys Lys Asn Val Leu Val Thr Gly Gly Phe Phe Gly Gly
    130                 135                 140                 
Phe Leu Leu Gly Met Ala Ser
145                 150     


<210> 1362
<211> 243
<212> PRT
<213> Homo sapiens

<400> 1362
Met Ala Ala Lys Val Asp Leu Ser Thr Ser Thr Asp Trp Lys Glu Ala
 1               5                  10                  15      
Lys Ser Phe Leu Lys Gly Leu Ser Asp Lys Gln Arg Glu Glu His Tyr
            20                  25                  30          
Phe Cys Lys Asp Phe Val Arg Leu Lys Lys Ile Pro Thr Trp Lys Glu
        35                  40                  45              
Met Ala Lys Gly Val Ala Val Lys Val Glu Glu Pro Arg Tyr Lys Lys
    50                  55                  60                  
Asp Lys Gln Leu Asn Glu Lys Ile Ser Leu Leu Arg Ser Asp Ile Thr
65                  70                  75                  80  
Lys Leu Glu Val Asp Ala Ile Val Asn Ala Ala Asn Ser Ser Leu Leu
                85                  90                  95      
Gly Gly Gly Gly Val Asp Gly Cys Ile His Arg Ala Ala Gly Pro Leu
            100                 105                 110         
Leu Thr Asp Glu Cys Arg Thr Leu Gln Ser Cys Lys Thr Gly Lys Ala
        115                 120                 125             
Lys Ile Thr Gly Gly Tyr Arg Leu Pro Ala Lys Tyr Val Ile His Thr
    130                 135                 140                 
Val Gly Pro Ile Ala Tyr Gly Glu Pro Ser Ala Ser Gln Ala Ala Glu
145                 150                 155                 160 
Leu Arg Ser Cys Tyr Leu Ser Ser Leu Asp Leu Leu Leu Glu His Arg
                165                 170                 175     
Leu Arg Ser Val Ala Phe Pro Cys Ile Ser Thr Gly Val Phe Gly Tyr
            180                 185                 190         
Pro Cys Glu Ala Ala Ala Glu Ile Val Leu Ala Thr Leu Arg Glu Trp
        195                 200                 205             
Leu Glu Gln His Lys Asp Lys Val Asp Arg Leu Ile Ile Cys Val Phe
    210                 215                 220                 
Leu Glu Lys Asp Glu Asp Ile Tyr Arg Ser Arg Leu Pro His Tyr Phe
225                 230                 235                 240 
Pro Val Ala
            


<210> 1363
<211> 254
<212> PRT
<213> Homo sapiens

<400> 1363
Met Ala Ala Tyr Lys Leu Val Leu Ile Arg His Gly Glu Ser Ala Trp
 1               5                  10                  15      
Asn Leu Glu Asn Arg Phe Ser Gly Trp Tyr Asp Ala Asp Leu Ser Pro
            20                  25                  30          
Ala Gly His Glu Glu Ala Lys Arg Gly Gly Gln Ala Leu Arg Asp Ala
        35                  40                  45              
Gly Tyr Glu Phe Asp Ile Cys Phe Thr Ser Val Gln Lys Arg Ala Ile
    50                  55                  60                  
Arg Thr Leu Trp Thr Val Leu Asp Ala Ile Asp Gln Met Trp Leu Pro
65                  70                  75                  80  
Val Val Arg Thr Trp Arg Leu Asn Glu Arg His Tyr Gly Gly Leu Thr
                85                  90                  95      
Gly Leu Asn Lys Ala Glu Thr Ala Ala Lys His Gly Glu Ala Gln Val
            100                 105                 110         
Lys Ile Trp Arg Arg Ser Tyr Asp Val Pro Pro Pro Pro Met Glu Pro
        115                 120                 125             
Asp His Pro Phe Tyr Ser Asn Ile Ser Lys Asp Arg Arg Tyr Ala Asp
    130                 135                 140                 
Leu Thr Glu Asp Gln Leu Pro Ser Cys Glu Ser Leu Lys Asp Thr Ile
145                 150                 155                 160 
Ala Arg Ala Leu Pro Phe Trp Asn Glu Glu Thr Val Pro Gln Ile Lys
                165                 170                 175     
Glu Gly Lys Arg Val Leu Ile Ala Ala His Gly Asn Ser Leu Arg Gly
            180                 185                 190         
Ile Val Lys His Leu Glu Gly Leu Ser Glu Glu Ala Ile Met Glu Leu
        195                 200                 205             
Asn Leu Pro Thr Gly Ile Pro Ile Val Tyr Glu Leu Asp Lys Asn Leu
    210                 215                 220                 
Lys Pro Ile Lys Pro Met Gln Phe Leu Gly Asp Glu Glu Thr Val Arg
225                 230                 235                 240 
Lys Ala Met Glu Ala Val Ala Ala Gln Gly Lys Ala Lys Lys
                245                 250                 


<210> 1364
<211> 430
<212> PRT
<213> Homo sapiens

<400> 1364
Met Ala Leu Leu His Ser Gly Arg Val Leu Pro Gly Ile Ala Ala Ala
 1               5                  10                  15      
Phe His Pro Gly Leu Ala Ala Ala Ala Ser Ala Arg Ala Ser Ser Trp
            20                  25                  30          
Trp Thr His Val Glu Met Gly Pro Pro Asp Pro Ile Leu Gly Val Thr
        35                  40                  45              
Glu Ala Phe Lys Arg Asp Thr Asn Ser Lys Lys Met Asn Leu Gly Val
    50                  55                  60                  
Gly Ala Tyr Arg Asp Asp Asn Gly Lys Pro Tyr Val Leu Pro Ser Val
65                  70                  75                  80  
Arg Lys Ala Glu Ala Gln Ile Ala Ala Lys Asn Leu Asp Lys Glu Tyr
                85                  90                  95      
Leu Pro Ile Gly Gly Leu Ala Glu Phe Cys Lys Ala Ser Ala Glu Leu
            100                 105                 110         
Ala Leu Gly Glu Asn Ser Glu Val Leu Lys Ser Gly Arg Phe Val Thr
        115                 120                 125             
Val Gln Thr Ile Ser Gly Thr Gly Ala Leu Arg Ile Gly Ala Ser Phe
    130                 135                 140                 
Leu Gln Arg Phe Phe Lys Phe Ser Arg Asp Val Phe Leu Pro Lys Pro
145                 150                 155                 160 
Thr Trp Gly Asn His Thr Pro Ile Phe Arg Asp Ala Gly Met Gln Leu
                165                 170                 175     
Gln Gly Tyr Arg Tyr Tyr Asp Pro Lys Thr Cys Gly Phe Asp Phe Thr
            180                 185                 190         
Gly Ala Val Glu Asp Ile Ser Lys Ile Pro Glu Gln Ser Val Leu Leu
        195                 200                 205             
Leu His Ala Cys Ala His Asn Pro Thr Gly Val Asp Pro Arg Pro Glu
    210                 215                 220                 
Gln Trp Lys Glu Ile Ala Thr Val Val Lys Lys Arg Asn Leu Phe Ala
225                 230                 235                 240 
Phe Phe Asp Met Ala Tyr Gln Gly Phe Ala Ser Gly Asp Gly Asp Lys
                245                 250                 255     
Asp Ala Trp Ala Val Arg His Phe Ile Glu Gln Gly Ile Asn Val Cys
            260                 265                 270         
Leu Cys Gln Ser Tyr Ala Lys Asn Met Gly Leu Tyr Gly Glu Arg Val
        275                 280                 285             
Gly Ala Phe Thr Met Val Cys Lys Asp Ala Asp Glu Ala Lys Arg Val
    290                 295                 300                 
Glu Ser Gln Leu Lys Ile Leu Ile Arg Pro Met Tyr Ser Asn Pro Pro
305                 310                 315                 320 
Leu Asn Gly Ala Arg Ile Ala Ala Ala Ile Leu Asn Thr Pro Asp Leu
                325                 330                 335     
Arg Lys Gln Trp Leu Gln Glu Val Lys Val Met Ala Asp Arg Ile Ile
            340                 345                 350         
Gly Met Arg Thr Gln Leu Val Ser Asn Leu Lys Lys Glu Gly Ser Thr
        355                 360                 365             
His Asn Trp Gln His Ile Thr Asp Gln Ile Gly Met Phe Cys Phe Thr
    370                 375                 380                 
Gly Leu Lys Pro Glu Gln Val Glu Arg Leu Ile Lys Glu Phe Ser Ile
385                 390                 395                 400 
Tyr Met Thr Lys Asp Gly Arg Ile Ser Val Ala Gly Val Thr Ser Ser
                405                 410                 415     
Asn Val Gly Tyr Leu Ala His Ala Ile His Gln Ala Thr Lys
            420                 425                 430 


<210> 1365
<211> 164
<212> PRT
<213> Homo sapiens

<400> 1365
His Glu Gly Glu Pro Ser Gly Ala Ala Val Ser Arg Ser Pro Leu Ser
 1               5                  10                  15      
Pro Pro Ser Arg Pro Phe Ala Ser Arg Glu Pro Ala Gly Phe Arg Ala
            20                  25                  30          
Ala Leu Ala Asp Pro Pro Gly Met Pro Arg Tyr Glu Leu Ala Leu Ile
        35                  40                  45              
Leu Lys Ala Met Gln Arg Pro Glu Thr Ala Ala Thr Leu Lys Arg Thr
    50                  55                  60                  
Ile Glu Ala Leu Met Asp Arg Gly Ala Ile Val Arg Asp Leu Glu Asn
65                  70                  75                  80  
Leu Gly Glu Arg Ala Leu Pro Tyr Arg Ile Ser Ala His Ser Gln Gln
                85                  90                  95      
His Asn Arg Gly Gly Tyr Phe Leu Val Asp Phe Tyr Ala Pro Thr Ala
            100                 105                 110         
Ala Val Glu Ser Met Val Glu His Leu Ser Arg Asp Ile Asp Val Ile
        115                 120                 125             
Arg Gly Asn Ile Val Lys His Pro Leu Thr Gln Glu Leu Lys Glu Cys
    130                 135                 140                 
Glu Gly Ile Val Pro Val Pro Leu Ala Glu Lys Leu Tyr Ser Thr Lys
145                 150                 155                 160 
Lys Arg Lys Lys
                


<210> 1366
<211> 219
<212> PRT
<213> Homo sapiens

<400> 1366
His Glu Ala Glu Gln Gly Gly Gly Gly Gly Gly Thr Cys Gly Ala Gly
 1               5                  10                  15      
Ala Arg Ala Met Gly Arg Leu His Cys Thr Glu Asp Pro Val Pro Glu
            20                  25                  30          
Ala Val Gly Gly Asp Met Gln Gln Leu Asn Gln Leu Gly Ala Gln Gln
        35                  40                  45              
Phe Ser Ala Leu Thr Glu Val Leu Phe His Phe Leu Thr Glu Pro Lys
    50                  55                  60                  
Glu Val Glu Arg Phe Leu Ala Gln Leu Ser Glu Phe Ala Thr Thr Asn
65                  70                  75                  80  
Gln Ile Ser Leu Gly Ser Leu Arg Ser Ile Val Lys Ser Leu Leu Leu
                85                  90                  95      
Val Pro Asn Gly Ala Leu Lys Lys Ser Leu Thr Ala Lys Gln Val Gln
            100                 105                 110         
Ala Asp Phe Ile Thr Leu Gly Leu Ser Glu Glu Lys Ala Thr Tyr Phe
        115                 120                 125             
Ser Glu Lys Trp Lys Gln Asn Ala Pro Thr Leu Ala Arg Trp Ala Ile
    130                 135                 140                 
Gly Gln Thr Leu Met Ile Asn Gln Leu Ile Asp Met Glu Trp Lys Phe
145                 150                 155                 160 
Gly Val Thr Ser Gly Ser Ser Glu Leu Glu Lys Val Gly Ser Ile Phe
                165                 170                 175     
Leu Gln Leu Lys Leu Val Val Lys Lys Gly Asn Gln Thr Glu Asn Val
            180                 185                 190         
Tyr Ile Glu Leu Thr Leu Pro Gln Phe Tyr Ser Phe Leu His Glu Met
        195                 200                 205             
Glu Arg Val Arg Thr Ser Met Glu Cys Phe Cys
    210                 215                 


<210> 1367
<211> 401
<212> PRT
<213> Homo sapiens

<400> 1367
Met Pro Lys Ile Val Leu Asn Gly Val Thr Val Asp Phe Pro Phe Gln
 1               5                  10                  15      
Pro Tyr Lys Cys Gln Gln Glu Tyr Met Thr Lys Val Leu Glu Cys Leu
            20                  25                  30          
Gln Gln Lys Val Asn Gly Ile Leu Glu Ser Pro Thr Gly Thr Gly Lys
        35                  40                  45              
Thr Leu Cys Leu Leu Cys Thr Thr Leu Ala Trp Arg Glu His Leu Arg
    50                  55                  60                  
Asp Gly Ile Ser Ala Arg Lys Ile Ala Glu Arg Ala Gln Gly Glu Leu
65                  70                  75                  80  
Phe Pro Asp Arg Ala Leu Ser Ser Trp Gly Asn Ala Ala Ala Ala Val
                85                  90                  95      
Gly Asp Pro Ile Ala Cys Tyr Thr Asp Ile Pro Lys Ile Ile Tyr Ala
            100                 105                 110         
Ser Arg Thr His Ser Gln Leu Thr Gln Val Ile Asn Glu Leu Arg Asn
        115                 120                 125             
Thr Ser Tyr Arg Ser Leu Leu Arg Pro Gly His Val Ser Val Met Leu
    130                 135                 140                 
Thr Ser Ser Asp Arg Arg Gly Ser Cys Val Ser Pro Tyr Ser Ser Arg
145                 150                 155                 160 
Cys Arg Ala Thr Leu Trp Val Leu Glu Thr Ala Pro Pro Arg Pro Thr
                165                 170                 175     
Val Leu Ser Pro Thr Arg Pro Lys Val Cys Val Leu Gly Ser Arg Glu
            180                 185                 190         
Gln Leu Cys Ile His Pro Glu Val Lys Lys Gln Glu Ser Asn His Leu
        195                 200                 205             
Gln Ile His Leu Cys Arg Lys Lys Val Ala Ser Arg Ser Cys His Phe
    210                 215                 220                 
Tyr Asn Asn Val Glu Glu Lys Ser Leu Glu Gln Glu Leu Ala Ser Pro
225                 230                 235                 240 
Ile Leu Asp Ile Asp Asp Leu Val Lys Ser Gly Ser Lys His Arg Val
                245                 250                 255     
Cys Pro Tyr Tyr Leu Ser Arg Asn Leu Lys Gln Gln Ala Asp Ile Ile
            260                 265                 270         
Phe Met Pro Tyr Asn Tyr Leu Leu Asp Ala Lys Ser Arg Arg Ala His
        275                 280                 285             
Asn Ile Asp Leu Lys Gly Thr Val Val Ile Phe Asp Glu Ala His Asn
    290                 295                 300                 
Val Glu Lys Met Cys Glu Glu Ser Ala Ser Phe Asp Leu Thr Pro His
305                 310                 315                 320 
Asp Leu Ala Ser Gly Leu Asp Val Ile Asp Gln Val Leu Glu Glu Gln
                325                 330                 335     
Thr Lys Ala Ala Gln Gln Gly Glu Pro His Pro Glu Phe Ser Ala Asp
            340                 345                 350         
Ser Pro Ser Pro Gly Cys Pro Gln Cys Cys Gln Cys Leu Ser Ala Asp
        355                 360                 365             
Trp Leu Pro Asn Cys Cys Ile Ser Thr Pro Phe Tyr His Gln Arg Val
    370                 375                 380                 
Gln Thr Ser Pro Gly Leu Val Cys Gly Asp Gly Leu His Leu Pro Thr
385                 390                 395                 400 
Cys
    


<210> 1368
<211> 308
<212> PRT
<213> Homo sapiens

<400> 1368
Met Asp Gly Gly Ser Gly Gly Leu Gly Ser Gly Asp Asn Ala Pro Thr
 1               5                  10                  15      
Thr Glu Ala Leu Phe Val Ala Leu Gly Ala Gly Val Thr Ala Leu Ser
            20                  25                  30          
His Pro Leu Leu Tyr Val Lys Leu Leu Ile Gln Val Gly His Glu Pro
        35                  40                  45              
Met Pro Pro Thr Leu Gly Thr Asn Val Leu Gly Arg Lys Val Leu Tyr
    50                  55                  60                  
Leu Pro Ser Phe Phe Thr Tyr Ala Lys Tyr Ile Val Gln Val Asp Gly
65                  70                  75                  80  
Lys Ile Gly Leu Phe Arg Gly Leu Ser Pro Arg Leu Met Ser Asn Ala
                85                  90                  95      
Leu Ser Thr Val Thr Arg Gly Ser Met Lys Lys Val Phe Pro Pro Asp
            100                 105                 110         
Glu Ile Glu Gln Val Ser Asn Lys Asp Asp Met Lys Thr Ser Leu Lys
        115                 120                 125             
Lys Val Val Lys Glu Thr Ser Tyr Glu Met Met Met Gln Cys Val Ser
    130                 135                 140                 
Arg Met Leu Ala His Pro Leu His Val Ile Ser Met Arg Cys Met Val
145                 150                 155                 160 
Gln Phe Val Gly Arg Glu Ala Lys Tyr Ser Gly Val Leu Ser Ser Ile
                165                 170                 175     
Gly Lys Ile Phe Lys Glu Glu Gly Leu Leu Gly Phe Phe Val Gly Leu
            180                 185                 190         
Ile Pro His Leu Leu Gly Asp Val Val Phe Leu Trp Gly Cys Asn Leu
        195                 200                 205             
Leu Ala His Phe Ile Asn Ala Tyr Leu Val Asp Asp Ser Phe Ser Gln
    210                 215                 220                 
Ala Leu Ala Ile Arg Ser Tyr Thr Lys Phe Val Met Gly Ile Ala Val
225                 230                 235                 240 
Ser Met Leu Thr Tyr Pro Phe Leu Leu Val Gly Asp Leu Met Ala Val
                245                 250                 255     
Asn Asn Cys Gly Leu Gln Ala Gly Leu Pro Pro Tyr Ser Pro Val Phe
            260                 265                 270         
Lys Ser Trp Ile His Cys Trp Lys Tyr Leu Ser Val Gln Gly Gln Leu
        275                 280                 285             
Phe Arg Gly Ser Ser Leu Leu Phe Arg Arg Val Ser Ser Gly Ser Cys
    290                 295                 300                 
Phe Ala Leu Glu
305             


<210> 1369
<211> 401
<212> PRT
<213> Homo sapiens

<400> 1369
Met Ala Asp Pro Lys Tyr Ala Asp Leu Pro Gly Ile Ala Arg Asn Glu
 1               5                  10                  15      
Pro Asp Val Tyr Glu Thr Ser Asp Leu Pro Glu Asp Asp Gln Ala Glu
            20                  25                  30          
Phe Asp Ala Glu Glu Leu Thr Ser Thr Ser Val Glu His Ile Ile Val
        35                  40                  45              
Asn Pro Asn Ala Ala Tyr Asp Lys Phe Lys Asp Lys Arg Val Gly Thr
    50                  55                  60                  
Lys Gly Leu Asp Phe Ser Asp Arg Ile Gly Lys Thr Lys Arg Thr Gly
65                  70                  75                  80  
Tyr Glu Ser Gly Glu Tyr Glu Met Leu Gly Glu Gly Leu Gly Val Lys
                85                  90                  95      
Glu Thr Pro Gln Gln Lys Tyr Gln Arg Leu Leu His Glu Val Gln Glu
            100                 105                 110         
Leu Thr Thr Glu Val Glu Lys Ile Lys Thr Thr Val Lys Glu Ser Ala
        115                 120                 125             
Thr Glu Glu Lys Leu Thr Pro Val Leu Leu Ala Lys Gln Leu Ala Ala
    130                 135                 140                 
Leu Lys Gln Gln Leu Val Ala Ser His Leu Glu Lys Leu Leu Gly Pro
145                 150                 155                 160 
Asp Ala Ala Ile Asn Leu Thr Asp Pro Asp Gly Ala Leu Ala Lys Arg
                165                 170                 175     
Leu Leu Leu Gln Leu Glu Ala Thr Lys Asn Ser Lys Gly Gly Ser Gly
            180                 185                 190         
Gly Lys Thr Thr Gly Thr Pro Pro Asp Ser Ser Leu Val Thr Tyr Glu
        195                 200                 205             
Leu His Ser Arg Pro Glu Gln Asp Lys Phe Ser Gln Ala Ala Lys Val
    210                 215                 220                 
Ala Glu Leu Glu Lys Arg Leu Thr Glu Leu Glu Thr Ala Val Arg Cys
225                 230                 235                 240 
Asp Gln Asp Ala Gln Asn Pro Leu Ser Ala Gly Leu Gln Gly Ala Cys
                245                 250                 255     
Leu Met Glu Thr Val Glu Leu Leu Gln Ala Lys Val Ser Ala Leu Asp
            260                 265                 270         
Leu Ala Val Leu Asp Gln Val Glu Ala Arg Leu Gln Ser Val Leu Gly
        275                 280                 285             
Lys Val Asn Glu Ile Ala Lys His Lys Ala Ser Val Glu Asp Ala Asp
    290                 295                 300                 
Thr Gln Ser Lys Val His Gln Leu Tyr Glu Thr Ile Gln Arg Trp Ser
305                 310                 315                 320 
Pro Ile Ala Ser Thr Leu Pro Glu Leu Val Gln Arg Leu Val Thr Ile
                325                 330                 335     
Lys Gln Leu His Glu Gln Ala Met Gln Phe Gly Gln Leu Leu Thr His
            340                 345                 350         
Leu Asp Thr Thr Gln Gln Met Ile Ala Asn Ser Leu Lys Asp Asn Thr
        355                 360                 365             
Thr Leu Leu Thr Gln Val Gln Thr Thr Met Arg Glu Asn Leu Ala Thr
    370                 375                 380                 
Val Glu Gly Asn Phe Ala Ser Ile Asp Glu Arg Met Lys Lys Leu Gly
385                 390                 395                 400 
Lys
    


<210> 1370
<211> 230
<212> PRT
<213> Homo sapiens

<400> 1370
Glu Met Pro Glu Asp Thr Glu Asp Leu Asp His Tyr Glu Met Lys Glu
 1               5                  10                  15      
Glu Glu Pro Ala Glu Gly Lys Lys Ser Glu Asp Asp Gly Ile Gly Lys
            20                  25                  30          
Glu Asn Leu Ala Ile Leu Glu Lys Ile Lys Lys Asn Gln Arg Gln Asp
        35                  40                  45              
Tyr Leu Asn Gly Ala Val Ser Gly Ser Val Gln Ala Thr Asp Arg Leu
    50                  55                  60                  
Met Lys Glu Leu Arg Asp Ile Tyr Arg Ser Gln Ser Phe Lys Gly Gly
65                  70                  75                  80  
Asn Tyr Ala Val Glu Leu Val Asn Asp Ser Leu Tyr Asp Trp Asn Val
                85                  90                  95      
Lys Leu Leu Lys Val Asp Gln Asp Ser Ala Leu His Asn Asp Leu Gln
            100                 105                 110         
Ile Leu Lys Glu Lys Glu Gly Ala Asp Phe Ile Leu Leu Asn Phe Ser
        115                 120                 125             
Phe Lys Asp Asn Phe Pro Phe Asp Pro Pro Phe Val Arg Val Val Ser
    130                 135                 140                 
Pro Val Leu Ser Gly Gly Tyr Val Leu Gly Gly Gly Ala Ile Cys Met
145                 150                 155                 160 
Glu Leu Leu Thr Lys Gln Gly Trp Ser Ser Ala Tyr Ser Ile Glu Ser
                165                 170                 175     
Val Ile Met Gln Ile Ser Ala Thr Leu Val Lys Gly Lys Ala Arg Val
            180                 185                 190         
Gln Phe Gly Ala Asn Lys Ser Gln Tyr Ser Leu Thr Arg Ala Gln Gln
        195                 200                 205             
Ser Tyr Lys Ser Leu Val Gln Ile His Glu Lys Asn Gly Trp Tyr Thr
    210                 215                 220                 
Pro Pro Lys Glu Asp Gly
225                 230 


<210> 1371
<211> 248
<212> PRT
<213> Homo sapiens

<400> 1371
Met Ile Cys Thr Phe Leu Arg Ala Val Gln Tyr Thr Glu Lys Leu His
 1               5                  10                  15      
Arg Ser Ser Ala Lys Arg Leu Leu Leu Pro Tyr Ile Val Leu Asn Lys
            20                  25                  30          
Ala Cys Leu Lys Thr Glu Pro Ser Leu Arg Cys Gly Leu Gln Tyr Gln
        35                  40                  45              
Lys Lys Thr Leu Arg Pro Arg Cys Ile Leu Gly Val Thr Gln Lys Thr
    50                  55                  60                  
Ile Trp Thr Gln Gly Pro Ser Pro Arg Lys Ala Lys Glu Asp Gly Ser
65                  70                  75                  80  
Lys Gln Val Ser Val His Arg Ser Gln Arg Gly Gly Thr Ala Val Pro
                85                  90                  95      
Thr Ser Gln Lys Val Lys Glu Ala Gly Arg Asp Phe Thr Tyr Leu Ile
            100                 105                 110         
Val Val Leu Phe Gly Ile Ser Ile Thr Gly Gly Leu Phe Tyr Thr Ile
        115                 120                 125             
Phe Lys Glu Leu Phe Ser Ser Ser Ser Pro Ser Lys Ile Tyr Gly Arg
    130                 135                 140                 
Ala Leu Glu Lys Cys Arg Ser His Pro Glu Val Ile Gly Val Phe Gly
145                 150                 155                 160 
Glu Ser Val Lys Gly Tyr Gly Glu Val Thr Arg Arg Gly Arg Arg Gln
                165                 170                 175     
His Val Arg Phe Thr Glu Tyr Val Lys Asp Gly Leu Lys His Thr Cys
            180                 185                 190         
Val Lys Phe Tyr Ile Glu Gly Ser Glu Pro Gly Lys Gln Gly Thr Val
        195                 200                 205             
Tyr Ala Gln Val Lys Glu Asn Pro Gly Ser Gly Glu Tyr Asp Phe Arg
    210                 215                 220                 
Tyr Ile Phe Val Glu Ile Glu Ser Tyr Pro Arg Arg Thr Ile Ile Ile
225                 230                 235                 240 
Glu Asp Asn Arg Ser Gln Asp Asp
                245             


<210> 1372
<211> 633
<212> PRT
<213> Homo sapiens

<400> 1372
Ala Ala Leu Gly Ser Ser Ser Gly Ser Ala Ser Pro Ala Val Ala Glu
 1               5                  10                  15      
Leu Cys Gln Asn Thr Pro Glu Thr Phe Leu Glu Ala Ser Lys Leu Leu
            20                  25                  30          
Leu Thr Tyr Ala Asp Asn Ile Leu Arg Asn Pro Asn Asp Glu Lys Tyr
        35                  40                  45              
Arg Ser Ile Arg Ile Gly Asn Thr Ala Phe Ser Thr Arg Leu Leu Pro
    50                  55                  60                  
Val Arg Gly Ala Val Glu Cys Leu Phe Glu Met Gly Phe Glu Glu Gly
65                  70                  75                  80  
Glu Thr His Leu Ile Phe Pro Lys Lys Ala Ser Val Glu Gln Leu Gln
                85                  90                  95      
Lys Ile Arg Asp Leu Ile Ala Ile Glu Arg Ser Ser Arg Leu Asp Gly
            100                 105                 110         
Ser Asn Lys Ser His Lys Val Lys Ser Ser Gln Gln Pro Ala Ala Ser
        115                 120                 125             
Thr Gln Leu Pro Thr Thr Pro Ser Ser Asn Pro Ser Gly Leu Asn Gln
    130                 135                 140                 
His Thr Arg Asn Arg Gln Gly Gln Ser Ser Asp Pro Pro Ser Ala Ser
145                 150                 155                 160 
Thr Val Ala Ala Asp Ser Ala Ile Leu Glu Val Leu Gln Ser Asn Ile
                165                 170                 175     
Gln His Val Leu Val Tyr Glu Asn Pro Ala Leu Gln Glu Lys Ala Leu
            180                 185                 190         
Ala Cys Ile Pro Val Gln Glu Leu Lys Arg Lys Ser Gln Glu Lys Leu
        195                 200                 205             
Ser Arg Ala Arg Lys Leu Asp Lys Gly Ile Asn Ile Ser Asp Glu Asp
    210                 215                 220                 
Phe Leu Leu Leu Glu Leu Leu His Trp Phe Lys Glu Glu Phe Phe His
225                 230                 235                 240 
Trp Val Asn Asn Val Leu Cys Ser Lys Cys Gly Gly Gln Thr Arg Ser
                245                 250                 255     
Arg Asp Arg Ser Leu Leu Pro Ser Asp Asp Glu Leu Lys Trp Gly Ala
            260                 265                 270         
Lys Glu Val Glu Asp His Tyr Cys Asp Ala Cys Gln Phe Ser Asn Arg
        275                 280                 285             
Phe Pro Arg Tyr Asn Asn Pro Glu Lys Leu Leu Glu Thr Arg Cys Gly
    290                 295                 300                 
Arg Cys Gly Glu Trp Ala Asn Cys Phe Thr Leu Cys Cys Arg Ala Val
305                 310                 315                 320 
Gly Phe Glu Ala Arg Tyr Val Trp Asp Tyr Thr Glu Leu Gln Arg Thr
                325                 330                 335     
Leu Ser Leu Lys Leu Thr Thr Leu Lys Glu Ile Gly Lys Thr Phe Leu
            340                 345                 350         
Arg Ile Ser Lys Arg Gln Lys Leu Ile Gln Val Val Asp Val Thr Trp
        355                 360                 365             
Arg Tyr Ser Cys Lys His Glu Glu Val Ile Ala Arg Arg Thr Lys Val
    370                 375                 380                 
Lys Glu Ala Leu Leu Arg Asp Thr Ile Asn Gly Leu Asn Lys Gln Arg
385                 390                 395                 400 
Gln Leu Phe Leu Ser Glu Asn Arg Arg Lys Glu Leu Leu Gln Arg Ile
                405                 410                 415     
Ile Val Glu Leu Val Glu Phe Ile Ser Pro Lys Thr Pro Lys Pro Gly
            420                 425                 430         
Glu Leu Gly Gly Arg Ile Ser Gly Ser Val Ala Trp Arg Val Ala Arg
        435                 440                 445             
Gly Glu Met Gly Leu Gln Arg Lys Glu Thr Leu Phe Ile Pro Cys Glu
    450                 455                 460                 
Asn Glu Lys Ile Ser Lys Gln Leu His Leu Cys Tyr Asn Ile Val Lys
465                 470                 475                 480 
Asp Arg Tyr Val Arg Val Ser Asn Asn Asn Gln Thr Ile Ser Gly Trp
                485                 490                 495     
Glu Asn Gly Val Trp Lys Met Glu Ser Ile Phe Arg Lys Val Glu Thr
            500                 505                 510         
Asp Trp His Met Val Tyr Leu Ala Arg Lys Glu Gly Ser Ser Phe Ala
        515                 520                 525             
Tyr Ile Ser Trp Lys Phe Glu Cys Gly Ser Val Gly Leu Lys Val Asp
    530                 535                 540                 
Ser Ile Ser Ile Arg Thr Ser Ser Gln Thr Phe Gln Thr Gly Thr Val
545                 550                 555                 560 
Glu Trp Lys Leu Arg Ser Asp Thr Ala Gln Val Glu Leu Thr Gly Asp
                565                 570                 575     
Asn Ser Leu His Ser Tyr Ala Asp Phe Ser Gly Ala Thr Glu Val Ile
            580                 585                 590         
Leu Glu Ala Glu Leu Ser Arg Gly Asp Gly Asp Val Ala Trp Gln His
        595                 600                 605             
Thr Gln Leu Phe Arg Gln Ser Leu Asn Asp His Glu Glu Asn Cys Leu
    610                 615                 620                 
Glu Ile Ile Ile Lys Phe Ser Asp Leu
625                 630             


<210> 1373
<211> 399
<212> PRT
<213> Homo sapiens

<400> 1373
Met Gln Ser Leu Ser Leu Gly Gln Thr Ser Ile Ser Lys Gly Leu Asn
 1               5                  10                  15      
Tyr Leu Thr Ile Met Ala Pro Gly Asn Leu Trp His Met Arg Asn Asn
            20                  25                  30          
Phe Leu Phe Gly Ser Arg Cys Trp Met Thr Arg Phe Ser Ala Glu Asn
        35                  40                  45              
Ile Phe Lys Ser Val Ser Phe Arg Leu Phe Gly Val Lys Cys His Asn
    50                  55                  60                  
Thr Asp Ser Glu Pro Leu Lys Asn Glu Asp Leu Leu Lys Asn Leu Leu
65                  70                  75                  80  
Thr Met Gly Val Asp Ile Asp Met Ala Arg Lys Arg Gln Pro Gly Val
                85                  90                  95      
Phe His Arg Met Ile Thr Asn Glu Gln Asp Leu Lys Met Phe Leu Leu
            100                 105                 110         
Ser Lys Gly Ala Ser Lys Glu Val Ile Ala Ser Ile Ile Ser Arg Tyr
        115                 120                 125             
Pro Arg Ala Ile Thr Arg Thr Pro Glu Asn Leu Ser Lys Arg Trp Asp
    130                 135                 140                 
Leu Trp Arg Lys Ile Val Thr Ser Asp Leu Glu Ile Val Asn Ile Leu
145                 150                 155                 160 
Glu Arg Ser Pro Glu Ser Phe Phe Arg Ser Asn Asn Asn Leu Asn Leu
                165                 170                 175     
Glu Asn Asn Ile Lys Phe Leu Tyr Ser Val Gly Leu Thr Arg Lys Cys
            180                 185                 190         
Leu Cys Arg Leu Leu Thr Asn Ala Pro Arg Thr Phe Ser Asn Ser Leu
        195                 200                 205             
Asp Leu Asn Lys Gln Met Val Glu Phe Leu Gln Ala Ala Gly Leu Ser
    210                 215                 220                 
Leu Gly His Asn Asp Pro Thr Asp Phe Val Arg Lys Ile Ile Phe Lys
225                 230                 235                 240 
Asn Pro Phe Ile Leu Ile Gln Ser Thr Lys Arg Val Lys Ala Asn Ile
                245                 250                 255     
Glu Phe Leu Arg Ser Thr Phe Asn Leu Asn Ser Glu Glu Leu Leu Val
            260                 265                 270         
Leu Ile Cys Gly Pro Gly Ala Glu Ile Leu Asp Leu Ser Asn Asp Tyr
        275                 280                 285             
Ala Arg Arg Ser Tyr Ala Asn Ile Lys Glu Lys Leu Phe Ser Leu Gly
    290                 295                 300                 
Cys Thr Glu Glu Glu Val Gln Lys Phe Val Leu Ser Tyr Pro Asp Val
305                 310                 315                 320 
Ile Phe Leu Ala Glu Lys Lys Phe Asn Asp Lys Ile Asp Cys Leu Met
                325                 330                 335     
Glu Glu Asn Ile Ser Ile Ser Gln Ile Ile Glu Asn Pro Arg Val Leu
            340                 345                 350         
Asp Ser Ser Ile Ser Thr Leu Lys Ser Arg Ile Lys Glu Leu Val Asn
        355                 360                 365             
Ala Gly Cys Asn Leu Ser Thr Leu Asn Ile Thr Leu Leu Ser Trp Ser
    370                 375                 380                 
Lys Lys Arg Tyr Glu Ala Lys Leu Lys Lys Leu Ser Arg Phe Ala
385                 390                 395                 


<210> 1374
<211> 293
<212> PRT
<213> Homo sapiens

<400> 1374
Met Arg Val Leu Val Gly Gly Gly Thr Gly Phe Ile Gly Thr Ala Leu
 1               5                  10                  15      
Thr Gln Leu Leu Asn Ala Arg Gly His Glu Val Thr Leu Val Ser Arg
            20                  25                  30          
Lys Pro Gly Pro Gly Arg Ile Thr Trp Asp Glu Leu Ala Ala Ser Gly
        35                  40                  45              
Leu Pro Ser Cys Asp Ala Ala Val Asn Leu Ala Gly Glu Asn Ile Leu
    50                  55                  60                  
Asn Pro Leu Arg Arg Trp Asn Glu Thr Phe Gln Lys Glu Val Leu Gly
65                  70                  75                  80  
Ser Arg Leu Glu Thr Thr Gln Leu Leu Ala Lys Ala Ile Thr Lys Ala
                85                  90                  95      
Pro Gln Pro Pro Lys Ala Trp Val Leu Val Thr Gly Val Ala Tyr Tyr
            100                 105                 110         
Gln Pro Ser Leu Thr Ala Glu Tyr Asp Glu Asp Ser Pro Gly Gly Asp
        115                 120                 125             
Phe Asp Phe Phe Ser Asn Leu Val Thr Lys Trp Glu Ala Ala Ala Arg
    130                 135                 140                 
Leu Pro Gly Asp Ser Thr Arg Gln Val Val Val Arg Ser Gly Val Val
145                 150                 155                 160 
Leu Gly Arg Gly Gly Gly Ala Met Gly His Met Leu Leu Pro Phe Arg
                165                 170                 175     
Leu Gly Leu Gly Gly Pro Ile Gly Ser Gly His Gln Phe Phe Pro Trp
            180                 185                 190         
Ile His Ile Gly Asp Leu Ala Gly Ile Leu Thr His Ala Leu Glu Ala
        195                 200                 205             
Asn His Val His Gly Val Leu Asn Gly Val Ala Pro Ser Ser Ala Thr
    210                 215                 220                 
Asn Ala Glu Phe Ala Gln Thr Phe Gly Ala Ala Leu Gly Arg Arg Ala
225                 230                 235                 240 
Phe Ile Pro Leu Pro Ser Ala Val Val Gln Ala Val Phe Gly Arg Gln
                245                 250                 255     
Arg Ala Ile Met Leu Leu Glu Gly Gln Lys Val Ile Pro Arg Arg Thr
            260                 265                 270         
Leu Ala Thr Gly Tyr Gln Tyr Ser Phe Pro Glu Leu Gly Ala Ala Leu
        275                 280                 285             
Lys Glu Ile Val Ala
    290             


<210> 1375
<211> 344
<212> PRT
<213> Homo sapiens

<400> 1375
Met Ala Ala Ile Tyr Gly Gly Val Glu Gly Gly Gly Thr Arg Ser Glu
 1               5                  10                  15      
Val Leu Leu Val Ser Glu Asp Gly Lys Ile Leu Ala Glu Ala Asp Gly
            20                  25                  30          
Leu Ser Thr Asn His Trp Leu Ile Gly Thr Asp Lys Cys Val Glu Arg
        35                  40                  45              
Ile Asn Glu Met Val Asn Arg Ala Lys Arg Lys Ala Gly Val Asp Pro
    50                  55                  60                  
Leu Val Pro Leu Arg Ser Leu Gly Leu Ser Leu Ser Gly Gly Asp Gln
65                  70                  75                  80  
Glu Asp Ala Gly Arg Ile Leu Ile Glu Glu Leu Arg Asp Arg Phe Pro
                85                  90                  95      
Tyr Leu Ser Glu Ser Tyr Leu Ile Thr Thr Asp Ala Ala Gly Ser Ile
            100                 105                 110         
Ala Thr Ala Thr Pro Asp Gly Gly Val Val Leu Ile Ser Gly Thr Gly
        115                 120                 125             
Ser Asn Cys Arg Leu Ile Asn Pro Asp Gly Ser Glu Ser Gly Cys Gly
    130                 135                 140                 
Gly Trp Gly His Met Met Gly Asp Glu Gly Ser Ala Tyr Trp Ile Ala
145                 150                 155                 160 
His Gln Ala Val Lys Ile Val Phe Asp Ser Ile Asp Asn Leu Glu Ala
                165                 170                 175     
Ala Pro His Asp Ile Gly Tyr Val Lys Gln Ala Met Phe His Tyr Phe
            180                 185                 190         
Gln Val Pro Asp Arg Leu Gly Ile Leu Thr His Leu Tyr Arg Asp Phe
        195                 200                 205             
Asp Lys Cys Arg Phe Ala Gly Phe Cys Arg Lys Ile Ala Glu Gly Ala
    210                 215                 220                 
Gln Gln Gly Asp Pro Leu Ser Arg Tyr Ile Phe Arg Lys Ala Gly Glu
225                 230                 235                 240 
Met Leu Gly Arg His Ile Val Ala Val Leu Pro Glu Ile Asp Pro Val
                245                 250                 255     
Leu Phe Gln Gly Lys Ile Gly Leu Pro Ile Leu Cys Val Gly Ser Val
            260                 265                 270         
Trp Lys Ser Trp Glu Leu Leu Lys Glu Gly Phe Leu Leu Ala Leu Thr
        275                 280                 285             
Gln Gly Arg Glu Ile Gln Ala Gln Asn Phe Phe Ser Ser Phe Thr Leu
    290                 295                 300                 
Met Lys Leu Arg His Ser Ser Ala Leu Gly Gly Ala Ser Leu Gly Ala
305                 310                 315                 320 
Arg His Ile Gly His Leu Leu Pro Met Asp Tyr Ser Ala Asn Ala Ile
                325                 330                 335     
Ala Phe Tyr Ser Tyr Thr Phe Ser
            340                 


<210> 1376
<211> 287
<212> PRT
<213> Homo sapiens

<400> 1376
Phe Leu Arg Arg Gly Pro Trp Ala Gln Leu Pro Ala Arg Phe Cys Ser
 1               5                  10                  15      
Arg Asp Pro Ala Gly Ala Gly Arg Arg Glu Ser Glu Pro Arg Pro Thr
            20                  25                  30          
Ser Ala Arg Gln Leu Asp Gly Ile Arg Asn Ile Val Leu Ser Asn Pro
        35                  40                  45              
Lys Lys Arg Asn Thr Leu Ser Leu Ala Met Leu Lys Ser Leu Gln Ser
    50                  55                  60                  
Asp Ile Leu His Asp Ala Asp Ser Asn Asp Leu Lys Val Ile Ile Ile
65                  70                  75                  80  
Ser Ala Glu Gly Pro Val Phe Ser Ser Gly His Asp Leu Lys Glu Leu
                85                  90                  95      
Thr Glu Glu Gln Gly Arg Asp Tyr His Ala Glu Val Phe Gln Thr Cys
            100                 105                 110         
Ser Lys Val Met Met His Ile Arg Asn His Pro Val Pro Val Ile Ala
        115                 120                 125             
Met Val Asn Gly Leu Ala Thr Ala Ala Gly Cys Gln Leu Val Ala Ser
    130                 135                 140                 
Cys Asp Ile Ala Val Ala Ser Asp Lys Ser Ser Phe Ala Thr Pro Gly
145                 150                 155                 160 
Val Asn Val Gly Leu Phe Cys Ser Thr Pro Gly Val Ala Leu Ala Arg
                165                 170                 175     
Ala Val Pro Arg Lys Val Ala Leu Glu Met Leu Phe Thr Gly Glu Pro
            180                 185                 190         
Ile Ser Ala Gln Glu Ala Leu Leu His Gly Leu Leu Ser Lys Val Val
        195                 200                 205             
Pro Glu Ala Glu Leu Gln Glu Glu Thr Met Arg Ile Ala Arg Lys Ile
    210                 215                 220                 
Ala Ser Leu Ser Arg Pro Val Val Ser Leu Gly Lys Ala Thr Phe Tyr
225                 230                 235                 240 
Lys Gln Leu Pro Gln Asp Leu Gly Thr Ala Tyr Tyr Leu Thr Ser Gln
                245                 250                 255     
Ala Met Val Asp Asn Leu Ala Leu Arg Asp Gly Gln Glu Gly Ile Thr
            260                 265                 270         
Ala Phe Leu Gln Lys Arg Lys Pro Val Trp Ser His Glu Pro Val
        275                 280                 285         


<210> 1377
<211> 534
<212> PRT
<213> Homo sapiens

<400> 1377
Met Arg Pro Asp Asp Lys Tyr His Glu Lys Gln Ala Gln Val Glu Ala
 1               5                  10                  15      
Thr Lys Leu Lys Gln Lys Val Glu Ala Leu Ser Pro Gly Asp Arg Gln
            20                  25                  30          
Gln Ile Tyr Glu Lys Gly Leu Glu Leu Arg Ser Gln Gln Ser Lys Pro
        35                  40                  45              
Gln Asp Ala Ser Cys Leu Pro Ala Leu Lys Val Ser Asp Ile Glu Pro
    50                  55                  60                  
Thr Ile Pro Val Thr Glu Leu Asp Val Val Leu Thr Ala Gly Asp Ile
65                  70                  75                  80  
Pro Val Gln Tyr Cys Ala Gln Pro Thr Asn Gly Met Val Tyr Phe Arg
                85                  90                  95      
Ala Phe Ser Ser Leu Asn Thr Leu Pro Glu Glu Leu Arg Pro Tyr Val
            100                 105                 110         
Pro Leu Phe Cys Ser Val Leu Thr Lys Leu Gly Cys Gly Leu Leu Asp
        115                 120                 125             
Tyr Arg Glu Gln Ala Gln Gln Ile Glu Leu Lys Thr Gly Gly Met Ser
    130                 135                 140                 
Ala Ser Pro His Val Leu Pro Asp Asp Ser His Met Asp Thr Tyr Glu
145                 150                 155                 160 
Gln Gly Val Leu Phe Ser Ser Leu Cys Leu Asp Arg Asn Leu Pro Asp
                165                 170                 175     
Met Met Gln Leu Trp Ser Glu Ile Phe Asn Asn Pro Cys Phe Glu Glu
            180                 185                 190         
Glu Glu His Phe Lys Val Leu Val Lys Met Thr Ala Gln Glu Leu Ala
        195                 200                 205             
Asn Gly Ile Pro Asp Ser Gly His Leu Tyr Ala Ser Ile Arg Ala Gly
    210                 215                 220                 
Arg Thr Leu Thr Pro Ala Gly Asp Leu Gln Glu Thr Phe Ser Gly Met
225                 230                 235                 240 
Asp Gln Val Arg Leu Met Lys Arg Ile Ala Glu Met Thr Asp Ile Lys
                245                 250                 255     
Pro Ile Leu Arg Lys Leu Pro Arg Ile Lys Lys His Leu Leu Asn Gly
            260                 265                 270         
Asp Asn Met Arg Cys Ser Val Asn Ala Thr Pro Gln Gln Met Pro Gln
        275                 280                 285             
Thr Glu Lys Ala Val Glu Asp Phe Leu Arg Ser Ile Gly Arg Ser Lys
    290                 295                 300                 
Lys Glu Arg Arg Pro Val Arg Pro His Thr Val Glu Lys Pro Val Pro
305                 310                 315                 320 
Ser Ser Ser Gly Gly Asp Ala His Val Pro His Gly Ser Gln Val Ile
                325                 330                 335     
Arg Lys Leu Val Met Glu Pro Thr Phe Lys Pro Trp Gln Met Lys Thr
            340                 345                 350         
His Phe Leu Met Pro Phe Pro Val Asn Tyr Val Gly Glu Cys Ile Arg
        355                 360                 365             
Thr Val Pro Tyr Thr Asp Pro Asp His Ala Ser Leu Lys Ile Leu Ala
    370                 375                 380                 
Arg Leu Met Thr Ala Lys Phe Leu His Thr Glu Ile Arg Glu Lys Gly
385                 390                 395                 400 
Gly Ala Tyr Gly Gly Gly Ala Lys Leu Ser His Asn Gly Ile Phe Thr
                405                 410                 415     
Leu Tyr Ser Tyr Arg Asp Pro Asn Thr Ile Glu Thr Leu Gln Ser Phe
            420                 425                 430         
Gly Lys Ala Val Asp Trp Ala Lys Ser Gly Lys Phe Thr Gln Gln Asp
        435                 440                 445             
Ile Asp Glu Ala Lys Leu Ser Val Phe Ser Thr Val Asp Ala Pro Val
    450                 455                 460                 
Ala Pro Ser Asp Lys Gly Met Asp His Phe Leu Tyr Gly Leu Ser Asp
465                 470                 475                 480 
Glu Met Lys Gln Ala His Arg Glu Gln Leu Phe Ala Val Ser His Asp
                485                 490                 495     
Lys Leu Leu Ala Val Ser Asp Arg Tyr Leu Gly Thr Gly Lys Ser Thr
            500                 505                 510         
His Gly Leu Ala Ile Leu Gly Pro Glu Asn Pro Lys Ile Ala Lys Asp
        515                 520                 525             
Pro Ser Trp Ile Ile Arg
    530                 


<210> 1378
<211> 427
<212> PRT
<213> Homo sapiens

<400> 1378
Met Arg His Leu Gly Ala Phe Leu Phe Leu Leu Gly Val Leu Gly Ala
 1               5                  10                  15      
Leu Thr Glu Met Cys Glu Ile Pro Glu Met Asp Ser His Leu Val Glu
            20                  25                  30          
Lys Leu Gly Gln His Leu Leu Pro Trp Met Asp Arg Leu Ser Leu Glu
        35                  40                  45              
His Leu Asn Pro Ser Ile Tyr Val Gly Leu Arg Leu Ser Ser Leu Gln
    50                  55                  60                  
Ala Gly Thr Lys Glu Asp Leu Tyr Leu His Ser Leu Lys Leu Gly Tyr
65                  70                  75                  80  
Gln Gln Cys Leu Leu Gly Ser Ala Phe Ser Glu Asp Asp Gly Asp Cys
                85                  90                  95      
Gln Gly Lys Pro Ser Met Gly Gln Leu Ala Leu Tyr Leu Leu Ala Leu
            100                 105                 110         
Arg Ala Asn Cys Glu Phe Val Arg Gly His Lys Gly Asp Arg Leu Val
        115                 120                 125             
Ser Gln Leu Lys Trp Phe Leu Glu Asp Glu Lys Arg Ala Ile Gly His
    130                 135                 140                 
Asp His Lys Gly His Pro His Thr Ser Tyr Tyr Gln Tyr Gly Leu Gly
145                 150                 155                 160 
Ile Leu Ala Leu Cys Leu His Gln Lys Arg Val His Asp Ser Val Val
                165                 170                 175     
Asp Lys Leu Leu Tyr Ala Val Glu Pro Phe His Gln Gly His His Ser
            180                 185                 190         
Val Asp Thr Ala Ala Met Ala Gly Leu Ala Phe Thr Cys Leu Lys Arg
        195                 200                 205             
Ser Asn Phe Asn Pro Gly Arg Arg Gln Arg Ile Thr Met Ala Ile Arg
    210                 215                 220                 
Thr Val Gln Glu Glu Ile Leu Lys Ala Gln Thr Pro Glu Gly His Phe
225                 230                 235                 240 
Gly Asn Val Tyr Ser Thr Pro Leu Ala Leu Gln Phe Leu Met Thr Ser
                245                 250                 255     
Pro Met Arg Gly Ala Glu Leu Gly Thr Ala Cys Leu Lys Ala Arg Val
            260                 265                 270         
Ala Leu Leu Ala Ser Leu Gln Asp Gly Ala Phe Gln Asn Ala Leu Met
        275                 280                 285             
Ile Ser Gln Leu Leu Pro Val Leu Asn His Lys Thr Tyr Ile Asp Leu
    290                 295                 300                 
Ile Phe Pro Asp Cys Leu Ala Pro Arg Val Met Leu Glu Pro Ala Ala
305                 310                 315                 320 
Glu Thr Ile Pro Gln Thr Gln Glu Ile Ile Ser Val Thr Leu Gln Val
                325                 330                 335     
Leu Ser Leu Leu Pro Pro Tyr Arg Gln Ser Ile Ser Val Leu Ala Gly
            340                 345                 350         
Ser Thr Val Glu Asp Val Leu Lys Lys Ala His Glu Leu Gly Gly Phe
        355                 360                 365             
Thr Tyr Glu Thr Gln Ala Ser Leu Ser Gly Pro Tyr Leu Thr Ser Val
    370                 375                 380                 
Met Gly Lys Ala Ala Gly Glu Arg Glu Phe Trp Gln Leu Leu Arg Asp
385                 390                 395                 400 
Pro Asn Thr Pro Leu Leu Gln Gly Ile Ala Asp Tyr Arg Pro Lys Asp
                405                 410                 415     
Gly Glu Thr Ile Glu Leu Arg Leu Val Ser Trp
            420                 425         


<210> 1379
<211> 373
<212> PRT
<213> Homo sapiens

<400> 1379
Met Trp Val Cys Ser Thr Leu Trp Arg Val Arg Thr Pro Ala Arg Gln
 1               5                  10                  15      
Trp Arg Gly Leu Leu Pro Ala Ser Gly Cys His Gly Pro Ala Ala Ser
            20                  25                  30          
Ser Tyr Ser Ala Ser Ala Glu Pro Ala Arg Val Arg Ala Leu Val Tyr
        35                  40                  45              
Gly His His Gly Asp Pro Ala Lys Val Val Glu Leu Lys Asn Leu Glu
    50                  55                  60                  
Leu Ala Ala Val Arg Gly Ser Asp Val Arg Val Lys Met Leu Ala Ala
65                  70                  75                  80  
Pro Ile Asn Pro Ser Asp Ile Asn Met Ile Gln Gly Asn Tyr Gly Leu
                85                  90                  95      
Leu Pro Glu Leu Pro Ala Val Gly Gly Asn Glu Gly Val Ala Gln Val
            100                 105                 110         
Val Ala Val Gly Ser Asn Val Thr Gly Leu Lys Pro Gly Asp Trp Val
        115                 120                 125             
Ile Pro Ala Asn Ala Gly Leu Gly Thr Trp Arg Thr Glu Ala Val Phe
    130                 135                 140                 
Ser Glu Glu Ala Leu Ile Gln Val Pro Ser Asp Ile Pro Leu Gln Ser
145                 150                 155                 160 
Ala Ala Thr Leu Gly Val Asn Pro Cys Thr Ala Tyr Arg Met Leu Met
                165                 170                 175     
Asp Phe Glu Gln Leu Gln Pro Gly Asp Ser Val Ile Gln Asn Ala Ser
            180                 185                 190         
Asn Ser Gly Val Gly Gln Ala Val Ile Gln Ile Ala Ala Ala Leu Gly
        195                 200                 205             
Leu Arg Thr Ile Asn Val Val Arg Asp Arg Pro Asp Ile Gln Lys Leu
    210                 215                 220                 
Ser Asp Arg Leu Lys Ser Leu Gly Ala Glu His Val Ile Thr Glu Glu
225                 230                 235                 240 
Glu Leu Arg Arg Pro Glu Met Lys Asn Phe Phe Lys Asp Met Pro Gln
                245                 250                 255     
Pro Arg Leu Ala Leu Asn Cys Val Gly Gly Lys Ser Ser Thr Glu Leu
            260                 265                 270         
Leu Arg Gln Leu Ala Arg Gly Gly Thr Met Val Thr Tyr Gly Gly Met
        275                 280                 285             
Ala Lys Gln Pro Val Val Ala Ser Val Ser Leu Leu Ile Phe Lys Asp
    290                 295                 300                 
Leu Lys Leu Arg Gly Phe Trp Leu Ser Gln Trp Lys Lys Asp His Ser
305                 310                 315                 320 
Pro Asp Gln Phe Lys Glu Leu Ile Leu Thr Leu Cys Asp Leu Ile Arg
                325                 330                 335     
Arg Gly Gln Leu Thr Ala Pro Ala Cys Ser Gln Val Pro Leu Gln Asp
            340                 345                 350         
Tyr Gln Ser Ala Leu Glu Ala Ser Met Lys Pro Phe Ile Ser Ser Lys
        355                 360                 365             
Gln Ile Leu Thr Met
    370             


<210> 1380
<211> 313
<212> PRT
<213> Homo sapiens

<400> 1380
Met Glu Thr Arg Ser Pro Gly Leu Asn Asn Met Lys Pro Gln Ser Leu
 1               5                  10                  15      
Gln Leu Val Leu Glu Glu Gln Val Leu Ala Leu Gln Gln Gln Met Ala
            20                  25                  30          
Glu Asn Gln Ala Ala Ser Trp Arg Lys Leu Lys Asn Ser Gln Glu Ala
        35                  40                  45              
Gln Gln Arg Gln Ala Thr Leu Val Arg Lys Leu Gln Ala Lys Val Leu
    50                  55                  60                  
Gln Tyr Arg Ser Trp Cys Gln Glu Leu Glu Lys Arg Leu Glu Ala Thr
65                  70                  75                  80  
Gly Gly Pro Ile Pro Gln Arg Trp Glu Asn Val Glu Glu Pro Asn Leu
                85                  90                  95      
Asp Glu Leu Leu Val Arg Leu Glu Glu Glu Gln Gln Arg Cys Glu Ser
            100                 105                 110         
Leu Ala Glu Val Asn Thr Gln Leu Arg Leu His Met Glu Lys Ala Asp
        115                 120                 125             
Val Val Asn Lys Ala Leu Arg Glu Asp Val Glu Lys Leu Thr Val Asp
    130                 135                 140                 
Trp Ser Arg Ala Arg Asp Glu Leu Met Arg Lys Glu Ser Gln Trp Gln
145                 150                 155                 160 
Met Glu Gln Glu Phe Phe Lys Gly Tyr Leu Lys Gly Glu His Gly Arg
                165                 170                 175     
Leu Leu Ser Leu Trp Arg Glu Val Val Thr Phe Arg Arg His Phe Leu
            180                 185                 190         
Glu Met Lys Ser Ala Thr Asp Arg Asp Leu Met Glu Leu Lys Ala Glu
        195                 200                 205             
His Val Arg Leu Ser Gly Ser Leu Leu Thr Cys Cys Leu Arg Leu Thr
    210                 215                 220                 
Val Gly Ala Gln Ser Arg Glu Pro Asn Gly Ser Gly Arg Met Asp Gly
225                 230                 235                 240 
Arg Glu Pro Ala Gln Leu Leu Leu Leu Leu Ala Lys Thr Gln Glu Leu
                245                 250                 255     
Glu Lys Glu Ala His Glu Arg Ser Gln Glu Leu Ile Gln Leu Lys Ser
            260                 265                 270         
Gln Gly Asp Leu Glu Lys Ala Glu Leu Gln Asp Arg Val Thr Glu Leu
        275                 280                 285             
Ser Ala Leu Leu Thr Gln Ser Gln Lys Gln Asn Glu Asp Tyr Glu Lys
    290                 295                 300                 
Met Ile Lys Ala Leu Arg Glu Thr Phe
305                 310             


<210> 1381
<211> 702
<212> PRT
<213> Homo sapiens

<400> 1381
His Glu Val Arg Ala Leu Leu Leu Trp Gly Arg Arg Leu Arg Pro Leu
 1               5                  10                  15      
Leu Arg Ala Pro Ala Leu Ala Ala Val Pro Gly Gly Lys Pro Ile Leu
            20                  25                  30          
Cys Pro Arg Arg Thr Thr Ala Gln Leu Gly Pro Arg Arg Asn Pro Ala
        35                  40                  45              
Trp Ser Leu Gln Ala Gly Arg Leu Phe Ser Thr Gln Thr Ala Glu Asp
    50                  55                  60                  
Lys Glu Glu Pro Leu His Ser Ile Ile Ser Ser Thr Glu Ser Val Gln
65                  70                  75                  80  
Gly Ser Thr Ser Lys His Glu Phe Gln Ala Glu Thr Lys Lys Leu Leu
                85                  90                  95      
Asp Ile Val Ala Arg Ser Leu Tyr Ser Glu Lys Glu Val Phe Ile Arg
            100                 105                 110         
Glu Leu Ile Ser Asn Ala Ser Asp Ala Leu Glu Lys Leu Arg His Lys
        115                 120                 125             
Leu Val Ser Asp Gly Gln Ala Leu Pro Glu Met Glu Ile His Leu Gln
    130                 135                 140                 
Thr Asn Ala Glu Lys Gly Thr Ile Thr Ile Gln Asp Thr Gly Ile Gly
145                 150                 155                 160 
Met Thr Gln Glu Glu Leu Val Ser Asn Leu Gly Thr Ile Ala Arg Ser
                165                 170                 175     
Gly Ser Lys Ala Phe Leu Asp Ala Leu Gln Asn Gln Ala Glu Ala Ser
            180                 185                 190         
Ser Lys Ile Ile Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala Phe Met
        195                 200                 205             
Val Ala Asp Arg Val Glu Val Tyr Ser Arg Ser Ala Ala Pro Gly Ser
    210                 215                 220                 
Leu Gly Tyr Gln Trp Leu Ser Asp Gly Ser Gly Val Phe Glu Ile Ala
225                 230                 235                 240 
Glu Ala Ser Gly Val Arg Thr Gly Thr Lys Ile Ile Ile His Leu Lys
                245                 250                 255     
Ser Asp Cys Lys Glu Phe Ser Ser Glu Ala Arg Val Arg Asp Val Val
            260                 265                 270         
Thr Lys Tyr Ser Asn Phe Val Ser Phe Pro Leu Tyr Leu Asn Gly Arg
        275                 280                 285             
Arg Met Asn Thr Leu Gln Ala Ile Trp Met Met Asp Pro Lys Asp Val
    290                 295                 300                 
Gly Glu Trp Gln His Glu Glu Phe Tyr Arg Tyr Val Ala Gln Ala His
305                 310                 315                 320 
Asp Lys Pro Arg Tyr Thr Leu His Tyr Lys Thr Asp Ala Pro Leu Asn
                325                 330                 335     
Ile Arg Ser Ile Phe Tyr Val Pro Asp Met Lys Pro Ser Met Phe Asp
            340                 345                 350         
Val Ser Arg Glu Leu Gly Ser Ser Val Ala Leu Tyr Ser Arg Lys Val
        355                 360                 365             
Leu Ile Gln Thr Lys Ala Thr Asp Ile Leu Pro Lys Trp Leu Arg Phe
    370                 375                 380                 
Ile Arg Gly Val Val Asp Ser Glu Asp Ile Pro Leu Asn Leu Ser Arg
385                 390                 395                 400 
Glu Leu Leu Gln Glu Ser Ala Leu Ile Arg Lys Leu Arg Asp Val Leu
                405                 410                 415     
Gln Gln Arg Leu Ile Lys Phe Phe Ile Asp Gln Ser Lys Lys Asp Ala
            420                 425                 430         
Glu Lys Tyr Ala Lys Phe Phe Glu Asp Tyr Gly Leu Phe Met Arg Glu
        435                 440                 445             
Gly Ile Val Thr Ala Thr Glu Gln Glu Val Lys Glu Asp Ile Ala Lys
    450                 455                 460                 
Leu Leu Arg Tyr Glu Ser Ser Ala Leu Pro Ser Gly Gln Leu Thr Ser
465                 470                 475                 480 
Leu Ser Glu Tyr Ala Ser Arg Met Arg Ala Gly Thr Arg Asn Ile Tyr
                485                 490                 495     
Tyr Leu Cys Ala Pro Asn Arg His Leu Ala Glu His Ser Pro Tyr Tyr
            500                 505                 510         
Glu Ala Met Lys Lys Lys Asp Thr Glu Val Leu Phe Cys Phe Glu Gln
        515                 520                 525             
Phe Asp Glu Leu Thr Leu Leu His Leu Arg Glu Phe Asp Lys Lys Lys
    530                 535                 540                 
Leu Ile Ser Val Glu Thr Asp Ile Val Val Asp His Tyr Lys Glu Glu
545                 550                 555                 560 
Lys Phe Glu Asp Arg Ser Pro Ala Ala Glu Cys Leu Ser Glu Lys Glu
                565                 570                 575     
Thr Glu Glu Leu Met Ala Trp Met Arg Asn Val Leu Gly Ser Arg Val
            580                 585                 590         
Thr Asn Val Lys Val Thr Leu Arg Leu Asp Thr His Pro Ala Met Val
        595                 600                 605             
Thr Val Leu Glu Met Gly Ala Ala Arg His Phe Leu Arg Met Gln Gln
    610                 615                 620                 
Leu Ala Lys Thr Gln Glu Glu Arg Ala Gln Leu Leu Gln Pro Thr Leu
625                 630                 635                 640 
Glu Ile Asn Pro Arg His Ala Leu Ile Lys Lys Leu Asn Gln Leu Cys
                645                 650                 655     
Ala Ser Glu Pro Gly Leu Ala Gln Leu Leu Val Asp Gln Ile Tyr Glu
            660                 665                 670         
Asn Ala Met Ile Ala Ala Gly Leu Val Asp Asp Pro Arg Ala Met Val
        675                 680                 685             
Gly Arg Leu Asn Glu Leu Leu Val Lys Ala Leu Glu Arg His
    690                 695                 700         


<210> 1382
<211> 30
<212> PRT
<213> Homo sapiens

<400> 1382
Cys His Leu Gly Gln Ala Pro Tyr Trp Ile Lys Thr Phe Ala Lys Gly
 1               5                  10                  15      
Thr Arg Leu Ile Val Thr Ser Pro Gly Asn Lys Gln Leu Asp
            20                  25                  30  


<210> 1383
<211> 1539
<212> PRT
<213> Homo sapiens

<400> 1383
Thr Leu Phe Lys Asp Ala Ser Gly Asn Leu Asp Lys Asn Ala Arg Phe
 1               5                  10                  15      
Ser Ala Ile Tyr Arg Gln Asp Ser Asn Lys Leu Ser Asn Asp Asp Met
            20                  25                  30          
Leu Lys Leu Leu Ala Asp Phe Arg Lys Pro Glu Lys Met Ala Lys Leu
        35                  40                  45              
Pro Val Ile Leu Gly Asn Leu Asp Ile Thr Ile Asp Asn Val Ser Ser
    50                  55                  60                  
Asp Phe Pro Asn Tyr Val Asn Ser Ser Tyr Ile Pro Thr Lys Gln Phe
65                  70                  75                  80  
Glu Thr Cys Ser Lys Thr Pro Ile Thr Phe Glu Val Glu Glu Phe Val
                85                  90                  95      
Pro Cys Ile Pro Lys His Thr Gln Pro Tyr Thr Ile Tyr Thr Asn His
            100                 105                 110         
Leu Tyr Val Tyr Pro Lys Tyr Leu Lys Tyr Asp Ser Gln Lys Ser Phe
        115                 120                 125             
Ala Lys Ala Arg Asn Ile Ala Ile Cys Ile Glu Phe Lys Asp Ser Asp
    130                 135                 140                 
Glu Glu Asp Ser Gln Pro Leu Lys Cys Ile Tyr Gly Arg Pro Gly Gly
145                 150                 155                 160 
Pro Val Phe Thr Arg Ser Ala Phe Ala Ala Val Leu His His His Gln
                165                 170                 175     
Asn Pro Glu Phe Tyr Asp Glu Ile Lys Ile Glu Leu Pro Thr Gln Leu
            180                 185                 190         
His Glu Lys His His Leu Leu Leu Thr Phe Phe His Val Ser Cys Asp
        195                 200                 205             
Asn Ser Ser Lys Gly Ser Thr Lys Lys Arg Asp Val Val Glu Thr Gln
    210                 215                 220                 
Val Gly Tyr Ser Trp Leu Pro Leu Leu Lys Asp Gly Arg Val Val Thr
225                 230                 235                 240 
Ser Glu Gln His Ile Pro Val Ser Ala Asn Leu Pro Ser Gly Tyr Leu
                245                 250                 255     
Gly Tyr Gln Glu Leu Gly Met Gly Arg His Tyr Gly Pro Glu Ile Lys
            260                 265                 270         
Trp Val Asp Gly Gly Lys Pro Leu Leu Lys Ile Ser Thr His Leu Val
        275                 280                 285             
Ser Thr Val Tyr Thr Gln Asp Gln His Leu His Asn Phe Phe Gln Tyr
    290                 295                 300                 
Cys Gln Lys Thr Glu Ser Gly Ala Gln Ala Leu Gly Asn Glu Leu Val
305                 310                 315                 320 
Lys Tyr Leu Lys Ser Leu His Ala Met Glu Gly His Val Met Ile Ala
                325                 330                 335     
Phe Leu Pro Thr Ile Leu Asn Gln Leu Phe Arg Val Leu Thr Arg Ala
            340                 345                 350         
Thr Gln Glu Glu Val Ala Val Asn Val Thr Arg Val Ile Ile His Val
        355                 360                 365             
Val Ala Gln Cys His Glu Glu Gly Leu Glu Ser His Leu Arg Ser Tyr
    370                 375                 380                 
Val Lys Tyr Ala Tyr Lys Ala Glu Pro Tyr Val Ala Ser Glu Tyr Lys
385                 390                 395                 400 
Thr Val His Glu Glu Leu Thr Lys Ser Met Thr Thr Ile Leu Lys Pro
                405                 410                 415     
Ser Ala Asp Phe Leu Thr Ser Asn Lys Leu Leu Lys Tyr Ser Trp Phe
            420                 425                 430         
Phe Phe Asp Val Leu Ile Lys Ser Met Ala Gln His Leu Ile Glu Asn
        435                 440                 445             
Ser Lys Val Lys Leu Leu Arg Asn Gln Arg Phe Pro Ala Ser Tyr His
    450                 455                 460                 
His Ala Val Glu Thr Val Val Asn Met Leu Met Pro His Ile Thr Gln
465                 470                 475                 480 
Lys Phe Arg Asp Asn Pro Glu Ala Ser Lys Asn Ala Asn His Ser Leu
                485                 490                 495     
Ala Val Phe Ile Lys Arg Cys Phe Thr Phe Met Asp Arg Gly Phe Val
            500                 505                 510         
Phe Lys Gln Ile Asn Asn Tyr Ile Ser Cys Phe Ala Pro Gly Asp Pro
        515                 520                 525             
Lys Thr Leu Phe Glu Tyr Lys Phe Glu Phe Leu Arg Val Val Cys Asn
    530                 535                 540                 
His Glu His Tyr Ile Pro Leu Asn Leu Pro Met Pro Phe Gly Lys Gly
545                 550                 555                 560 
Arg Ile Gln Arg Tyr Gln Asp Leu Gln Leu Asp Tyr Ser Leu Thr Asp
                565                 570                 575     
Glu Phe Cys Arg Asn His Phe Leu Val Gly Leu Leu Leu Arg Glu Val
            580                 585                 590         
Gly Thr Ala Leu Gln Glu Phe Arg Glu Val Arg Leu Ile Ala Ile Ser
        595                 600                 605             
Val Leu Lys Asn Leu Leu Ile Lys His Ser Phe Asp Asp Arg Tyr Ala
    610                 615                 620                 
Ser Arg Ser His Gln Ala Arg Ile Ala Thr Leu Tyr Leu Pro Leu Phe
625                 630                 635                 640 
Gly Leu Leu Ile Glu Asn Val Gln Arg Ile Asn Val Arg Asp Val Ser
                645                 650                 655     
Pro Phe Pro Val Asn Ala Gly Met Thr Val Lys Asp Glu Ser Leu Ala
            660                 665                 670         
Leu Pro Ala Val Asn Pro Leu Val Thr Pro Gln Lys Gly Ser Thr Leu
        675                 680                 685             
Asp Asn Ser Leu His Lys Asp Leu Leu Gly Ala Ile Ser Gly Ile Ala
    690                 695                 700                 
Ser Pro Tyr Thr Thr Ser Thr Pro Asn Ile Asn Ser Val Arg Asn Ala
705                 710                 715                 720 
Asp Ser Arg Gly Ser Leu Ile Ser Thr Asp Ser Gly Asn Ser Leu Pro
                725                 730                 735     
Glu Arg Asn Ser Glu Lys Ser Asn Ser Leu Asp Lys His Gln Gln Ser
            740                 745                 750         
Ser Thr Leu Gly Asn Ser Val Val Arg Cys Asp Lys Leu Asp Gln Ser
        755                 760                 765             
Glu Ile Lys Ser Leu Leu Met Cys Phe Leu Tyr Ile Leu Lys Ser Met
    770                 775                 780                 
Ser Asp Asp Ala Leu Phe Thr Tyr Trp Asn Lys Ala Ser Thr Ser Glu
785                 790                 795                 800 
Leu Met Asp Phe Phe Thr Ile Ser Glu Val Cys Leu His Gln Phe Gln
                805                 810                 815     
Tyr Met Gly Lys Arg Tyr Ile Ala Arg Thr Gly Met Met His Ala Arg
            820                 825                 830         
Leu Gln Gln Leu Gly Ser Leu Asp Asn Ser Leu Thr Phe Asn His Ser
        835                 840                 845             
Tyr Gly His Ser Asp Ala Asp Val Leu His Gln Ser Leu Leu Glu Ala
    850                 855                 860                 
Asn Ile Ala Thr Glu Val Cys Leu Thr Ala Leu Asp Thr Leu Ser Leu
865                 870                 875                 880 
Phe Thr Leu Ala Phe Lys Asn Gln Leu Leu Ala Asp His Gly His Asn
                885                 890                 895     
Pro Leu Met Lys Lys Val Phe Asp Val Tyr Leu Cys Phe Leu Gln Lys
            900                 905                 910         
His Gln Ser Glu Thr Ala Leu Lys Asn Val Phe Thr Ala Leu Arg Ser
        915                 920                 925             
Leu Ile Tyr Lys Phe Pro Ser Thr Phe Tyr Glu Gly Arg Ala Asp Met
    930                 935                 940                 
Cys Ala Ala Leu Cys Tyr Glu Ile Leu Lys Cys Cys Asn Ser Lys Leu
945                 950                 955                 960 
Ser Ser Ile Arg Thr Glu Ala Ser Gln Leu Leu Tyr Phe Leu Met Arg
                965                 970                 975     
Asn Asn Phe Asp Tyr Thr Gly Lys Lys Ser Phe Val Arg Thr His Leu
            980                 985                 990         
Gln Val Ile Ile Ser Val Ser Gln Leu Ile Ala Asp Val Val Gly Ile
        995                 1000                1005            
Gly Gly Thr Arg Phe Gln Gln Ser Leu Ser Ile Ile Asn Asn Cys Ala
    1010                1015                1020                
Asn Ser Asp Arg Leu Ile Lys His Thr Ser Phe Ser Ser Asp Val Lys
1025                1030                1035                1040
Asp Leu Thr Lys Arg Ile Arg Thr Val Leu Met Ala Thr Ala Gln Met
                1045                1050                1055    
Lys Glu His Glu Asn Asp Pro Glu Met Leu Val Asp Leu Gln Tyr Ser
            1060                1065                1070        
Leu Ala Lys Ser Tyr Ala Ser Thr Pro Glu Leu Arg Lys Thr Trp Leu
        1075                1080                1085            
Asp Ser Met Ala Arg Ile His Val Lys Asn Gly Asp Leu Ser Glu Ala
    1090                1095                1100                
Ala Met Cys Tyr Val His Val Thr Ala Leu Val Ala Glu Tyr Leu Thr
1105                1110                1115                1120
Arg Lys Glu Ala Val Gln Trp Glu Pro Pro Leu Leu Pro His Ser His
                1125                1130                1135    
Ser Ala Cys Leu Arg Arg Ser Arg Gly Gly Val Phe Arg Gln Gly Cys
            1140                1145                1150        
Thr Ala Phe Arg Val Ile Thr Pro Asn Ile Asp Glu Glu Ala Ser Met
        1155                1160                1165            
Met Glu Asp Val Gly Met Gln Asp Val His Phe Asn Glu Asp Val Leu
    1170                1175                1180                
Met Glu Leu Leu Glu Gln Cys Ala Asp Gly Leu Trp Lys Ala Glu Arg
1185                1190                1195                1200
Tyr Glu Leu Ile Ala Asp Ile Tyr Lys Leu Ile Ile Pro Ile Tyr Glu
                1205                1210                1215    
Lys Arg Arg Asp Phe Glu Arg Leu Ala His Leu Tyr Asp Thr Leu His
            1220                1225                1230        
Arg Ala Tyr Ser Lys Val Thr Glu Val Met His Ser Gly Arg Arg Leu
        1235                1240                1245            
Leu Gly Thr Tyr Phe Arg Val Ala Phe Phe Gly Gln Ala Ala Gln Tyr
    1250                1255                1260                
Gln Phe Thr Asp Ser Glu Thr Asp Val Glu Gly Phe Phe Glu Asp Glu
1265                1270                1275                1280
Asp Gly Lys Glu Tyr Ile Tyr Lys Glu Pro Lys Leu Thr Pro Leu Ser
                1285                1290                1295    
Glu Ile Ser Gln Arg Leu Leu Lys Leu Tyr Ser Asp Lys Phe Gly Ser
            1300                1305                1310        
Glu Asn Val Lys Met Ile Gln Asp Ser Gly Lys Val Asn Pro Lys Asp
        1315                1320                1325            
Leu Asp Ser Lys Tyr Ala Tyr Ile Gln Val Thr His Val Ile Pro Phe
    1330                1335                1340                
Phe Asp Glu Lys Glu Leu Gln Glu Arg Lys Thr Glu Phe Glu Arg Ser
1345                1350                1355                1360
His Asn Ile Arg Arg Phe Met Phe Glu Met Pro Phe Thr Gln Thr Gly
                1365                1370                1375    
Lys Arg Gln Gly Gly Val Glu Glu Gln Cys Lys Arg Arg Thr Ile Leu
            1380                1385                1390        
Thr Ala Ile His Cys Phe Pro Tyr Val Lys Lys Arg Ile Pro Val Met
        1395                1400                1405            
Tyr Gln His His Thr Asp Leu Asn Pro Ile Glu Val Ala Ile Asp Glu
    1410                1415                1420                
Met Ser Lys Lys Val Ala Glu Leu Arg Gln Leu Cys Ser Ser Ala Glu
1425                1430                1435                1440
Val Asp Met Ile Lys Leu Gln Leu Lys Leu Gln Gly Ser Val Ser Val
                1445                1450                1455    
Gln Val Asn Ala Gly Pro Leu Ala Tyr Ala Arg Ala Phe Leu Asp Asp
            1460                1465                1470        
Thr Asn Thr Lys Arg Tyr Pro Asp Asn Lys Val Lys Leu Leu Lys Glu
        1475                1480                1485            
Val Phe Arg Gln Phe Val Glu Ala Cys Gly Gln Ala Leu Ala Val Asn
    1490                1495                1500                
Glu Arg Leu Ile Lys Glu Asp Gln Leu Glu Tyr Gln Glu Glu Met Lys
1505                1510                1515                1520
Ala Asn Tyr Arg Glu Met Ala Lys Glu Leu Ser Glu Ile Met His Glu
                1525                1530                1535    
Gln Leu Gly
            


<210> 1384
<211> 878
<212> PRT
<213> Homo sapiens

<400> 1384
Met Ala Thr Ala Pro Ser Tyr Pro Ala Gly Leu Pro Gly Ser Pro Gly
 1               5                  10                  15      
Pro Gly Ser Pro Pro Pro Pro Gly Gly Leu Glu Leu Gln Ser Pro Pro
            20                  25                  30          
Pro Leu Leu Pro Gln Ile Pro Ala Pro Gly Ser Gly Val Ser Phe His
        35                  40                  45              
Ile Gln Ile Gly Leu Thr Arg Glu Phe Val Leu Leu Pro Ala Ala Ser
    50                  55                  60                  
Glu Leu Ala His Val Lys Gln Leu Ala Cys Ser Ile Val Asp Gln Lys
65                  70                  75                  80  
Phe Pro Glu Cys Gly Phe Tyr Gly Leu Tyr Asp Lys Ile Leu Leu Phe
                85                  90                  95      
Lys His Asp Pro Thr Ser Ala Asn Leu Leu Gln Leu Val Arg Ser Ser
            100                 105                 110         
Gly Asp Ile Gln Glu Gly Asp Leu Val Glu Val Val Leu Ser Ala Ser
        115                 120                 125             
Ala Thr Phe Glu Asp Phe Gln Ile Arg Pro His Ala Leu Thr Val His
    130                 135                 140                 
Ser Tyr Arg Ala Pro Ala Phe Cys Asp His Cys Gly Glu Met Leu Phe
145                 150                 155                 160 
Gly Leu Val Arg Gln Gly Leu Lys Cys Asp Gly Cys Gly Leu Asn Tyr
                165                 170                 175     
His Lys Arg Cys Ala Phe Ser Ile Pro Asn Asn Cys Ser Gly Ala Arg
            180                 185                 190         
Lys Arg Arg Leu Ser Ser Thr Ser Leu Ala Ser Gly His Ser Val Arg
        195                 200                 205             
Leu Gly Thr Ser Glu Ser Leu Pro Cys Thr Ala Glu Glu Leu Ser Arg
    210                 215                 220                 
Ser Thr Thr Glu Leu Leu Pro Arg Arg Pro Pro Ser Ser Ser Ser Ser
225                 230                 235                 240 
Ser Ser Ala Ser Ser Tyr Thr Gly Arg Pro Ile Glu Leu Asp Lys Met
                245                 250                 255     
Leu Leu Ser Lys Val Lys Val Pro His Thr Phe Leu Ile His Ser Tyr
            260                 265                 270         
Thr Arg Pro Thr Val Cys Gln Ala Cys Lys Lys Leu Leu Lys Gly Leu
        275                 280                 285             
Phe Arg Gln Gly Leu Gln Cys Lys Asp Cys Lys Phe Asn Cys His Lys
    290                 295                 300                 
Arg Cys Ala Thr Arg Val Pro Asn Asp Cys Leu Gly Glu Ala Leu Ile
305                 310                 315                 320 
Asn Gly Asp Val Pro Met Glu Glu Ala Thr Asp Phe Ser Glu Ala Asp
                325                 330                 335     
Lys Ser Ala Leu Met Asp Glu Ser Glu Asp Ser Gly Val Ile Pro Gly
            340                 345                 350         
Ser His Ser Glu Asn Ala Leu His Ala Ser Glu Glu Glu Glu Gly Glu
        355                 360                 365             
Gly Gly Lys Ala Gln Ser Ser Leu Gly Tyr Ile Pro Leu Met Arg Val
    370                 375                 380                 
Val Gln Ser Val Arg His Thr Thr Arg Lys Ser Ser Thr Thr Leu Arg
385                 390                 395                 400 
Glu Gly Trp Val Val His Tyr Ser Asn Lys Asp Thr Leu Arg Lys Arg
                405                 410                 415     
His Tyr Trp Arg Leu Asp Cys Lys Cys Ile Thr Leu Phe Gln Asn Asn
            420                 425                 430         
Thr Thr Asn Arg Tyr Tyr Lys Glu Ile Pro Leu Ser Glu Ile Leu Thr
        435                 440                 445             
Val Glu Ser Ala Gln Asn Phe Ser Leu Val Pro Pro Gly Thr Asn Pro
    450                 455                 460                 
His Cys Phe Glu Ile Val Thr Ala Asn Ala Thr Tyr Phe Val Gly Glu
465                 470                 475                 480 
Met Pro Gly Gly Thr Pro Gly Gly Pro Ser Gly Gln Gly Ala Glu Ala
                485                 490                 495     
Ala Arg Gly Trp Glu Thr Ala Ile Arg Gln Ala Leu Met Pro Val Ile
            500                 505                 510         
Leu Gln Asp Ala Pro Ser Ala Pro Gly His Ala Pro His Arg Gln Ala
        515                 520                 525             
Ser Leu Ser Ile Ser Val Ser Asn Ser Gln Ile Gln Glu Asn Val Asp
    530                 535                 540                 
Ile Ala Thr Val Tyr Gln Ile Phe Pro Asp Glu Val Leu Gly Ser Gly
545                 550                 555                 560 
Gln Phe Gly Val Val Tyr Gly Gly Lys His Arg Lys Thr Gly Arg Asp
                565                 570                 575     
Val Ala Val Lys Val Ile Asp Lys Leu Arg Phe Pro Thr Lys Gln Glu
            580                 585                 590         
Ser Gln Leu Arg Asn Glu Val Ala Ile Leu Gln Ser Leu Arg His Pro
        595                 600                 605             
Gly Ile Val Asn Leu Glu Cys Met Phe Glu Thr Pro Glu Lys Val Phe
    610                 615                 620                 
Val Val Met Glu Lys Leu His Gly Asp Met Leu Glu Met Ile Leu Ser
625                 630                 635                 640 
Ser Glu Lys Gly Arg Leu Pro Glu Arg Leu Thr Lys Phe Leu Ile Thr
                645                 650                 655     
Gln Ile Leu Val Ala Leu Arg His Leu His Phe Lys Asn Ile Val His
            660                 665                 670         
Cys Asp Leu Lys Pro Glu Asn Val Leu Leu Ala Ser Ala Asp Pro Phe
        675                 680                 685             
Pro Gln Val Lys Leu Cys Asp Phe Gly Phe Ala Arg Ile Ile Gly Glu
    690                 695                 700                 
Lys Ser Phe Arg Arg Ser Val Val Gly Thr Pro Ala Tyr Leu Ala Pro
705                 710                 715                 720 
Glu Val Leu Leu Asn Gln Gly Tyr Asn Arg Ser Leu Asp Met Trp Ser
                725                 730                 735     
Val Gly Val Ile Met Tyr Val Ser Leu Ser Gly Thr Phe Pro Phe Asn
            740                 745                 750         
Glu Asp Glu Asp Ile Asn Asp Gln Ile Gln Asn Ala Ala Phe Met Tyr
        755                 760                 765             
Pro Ala Ser Pro Trp Ser His Ile Ser Ala Gly Ala Ile Asp Leu Ile
    770                 775                 780                 
Asn Asn Leu Leu Gln Val Lys Met Arg Lys Arg Tyr Ser Val Asp Lys
785                 790                 795                 800 
Ser Leu Ser His Pro Trp Leu Gln Glu Tyr Gln Thr Trp Leu Asp Leu
                805                 810                 815     
Arg Glu Leu Glu Gly Lys Met Gly Glu Arg Tyr Ile Thr His Glu Ser
            820                 825                 830         
Asp Asp Ala Arg Trp Glu Gln Phe Ala Ala Glu His Pro Leu Pro Gly
        835                 840                 845             
Ser Gly Leu Pro Thr Asp Arg Asp Leu Gly Gly Ala Cys Pro Pro Gln
    850                 855                 860                 
Asp His Asp Met Gln Gly Leu Ala Glu Arg Ile Ser Val Leu
865                 870                 875             


<210> 1385
<211> 711
<212> PRT
<213> Homo sapiens

<400> 1385
Met Lys Leu Lys Leu Asn Val Leu Thr Ile Ile Leu Leu Pro Val His
 1               5                  10                  15      
Leu Leu Ile Thr Ile Tyr Ser Ala Leu Ile Phe Ile Pro Trp Tyr Phe
            20                  25                  30          
Leu Thr Asn Ala Lys Lys Lys Asn Ala Met Ala Lys Arg Ile Lys Ala
        35                  40                  45              
Lys Pro Thr Ser Asp Lys Pro Gly Ser Pro Tyr Arg Ser Val Thr His
    50                  55                  60                  
Phe Asp Ser Leu Ala Val Ile Asp Ile Pro Gly Ala Asp Thr Leu Asp
65                  70                  75                  80  
Lys Leu Phe Asp His Ala Val Ser Lys Phe Gly Lys Lys Asp Ser Leu
                85                  90                  95      
Gly Thr Arg Glu Ile Leu Ser Glu Glu Asn Glu Met Gln Pro Asn Gly
            100                 105                 110         
Lys Val Phe Lys Lys Leu Ile Leu Gly Asn Tyr Lys Trp Met Asn Tyr
        115                 120                 125             
Leu Glu Val Asn Arg Arg Val Asn Asn Phe Gly Ser Gly Leu Thr Ala
    130                 135                 140                 
Leu Gly Leu Lys Pro Lys Asn Thr Ile Ala Ile Phe Cys Glu Thr Arg
145                 150                 155                 160 
Ala Glu Trp Met Ile Ala Ala Gln Thr Cys Phe Lys Tyr Asn Phe Pro
                165                 170                 175     
Leu Val Thr Leu Tyr Ala Thr Leu Gly Lys Glu Ala Val Val His Gly
            180                 185                 190         
Leu Asn Glu Ser Glu Ala Ser Tyr Leu Ile Thr Ser Val Glu Leu Leu
        195                 200                 205             
Glu Ser Lys Leu Lys Thr Ala Leu Leu Asp Ile Ser Cys Val Lys His
    210                 215                 220                 
Ile Ile Tyr Val Asp Asn Lys Ala Ile Asn Lys Ala Glu Tyr Pro Glu
225                 230                 235                 240 
Gly Phe Glu Ile His Ser Met Gln Ser Val Glu Glu Leu Gly Ser Asn
                245                 250                 255     
Pro Glu Asn Leu Gly Ile Pro Pro Ser Arg Pro Thr Pro Ser Asp Met
            260                 265                 270         
Ala Ile Val Met Tyr Thr Ser Gly Ser Thr Gly Arg Pro Lys Gly Val
        275                 280                 285             
Met Met His His Ser Asn Leu Ile Ala Gly Met Thr Gly Gln Cys Glu
    290                 295                 300                 
Arg Ile Pro Gly Leu Gly Pro Lys Asp Thr Tyr Ile Gly Tyr Leu Pro
305                 310                 315                 320 
Leu Ala His Val Leu Glu Leu Thr Ala Glu Ile Ser Cys Phe Thr Tyr
                325                 330                 335     
Gly Cys Arg Ile Gly Tyr Ser Ser Pro Leu Thr Leu Ser Asp Gln Ser
            340                 345                 350         
Ser Lys Ile Lys Lys Gly Ser Lys Gly Asp Cys Thr Val Leu Lys Pro
        355                 360                 365             
Thr Leu Met Ala Ala Val Pro Glu Ile Met Asp Arg Ile Tyr Lys Asn
    370                 375                 380                 
Val Met Ser Lys Val Gln Glu Met Asn Tyr Ile Gln Lys Thr Leu Phe
385                 390                 395                 400 
Lys Ile Gly Tyr Asp Tyr Lys Leu Glu Gln Ile Lys Lys Gly Tyr Asp
                405                 410                 415     
Ala Pro Leu Cys Asn Leu Leu Leu Phe Lys Lys Val Lys Ala Leu Leu
            420                 425                 430         
Gly Gly Asn Val Arg Met Met Leu Ser Gly Gly Ala Pro Leu Ser Pro
        435                 440                 445             
Gln Thr His Arg Phe Met Asn Val Cys Phe Cys Cys Pro Ile Gly Gln
    450                 455                 460                 
Gly Tyr Gly Leu Thr Glu Ser Cys Gly Ala Gly Thr Val Thr Glu Val
465                 470                 475                 480 
Thr Asp Tyr Thr Thr Gly Arg Val Gly Ala Pro Leu Ile Cys Cys Glu
                485                 490                 495     
Ile Lys Leu Lys Asp Trp Gln Glu Gly Gly Tyr Thr Ile Asn Asp Lys
            500                 505                 510         
Pro Asn Pro Arg Gly Glu Ile Val Ile Gly Gly Gln Asn Ile Ser Met
        515                 520                 525             
Gly Tyr Phe Lys Asn Glu Glu Lys Thr Ala Glu Asp Tyr Ser Val Asp
    530                 535                 540                 
Glu Asn Gly Gln Arg Trp Phe Cys Thr Gly Asp Ile Gly Glu Phe His
545                 550                 555                 560 
Pro Asp Gly Cys Leu Gln Ile Ile Asp Arg Lys Lys Asp Leu Val Lys
                565                 570                 575     
Leu Gln Ala Gly Glu Tyr Val Ser Leu Gly Lys Val Glu Ala Ala Leu
            580                 585                 590         
Lys Asn Cys Pro Leu Ile Asp Asn Ile Cys Ala Phe Ala Lys Ser Asp
        595                 600                 605             
Gln Ser Tyr Val Ile Ser Phe Val Val Pro Asn Gln Lys Arg Leu Thr
    610                 615                 620                 
Leu Leu Ala Gln Gln Lys Gly Val Glu Gly Thr Trp Val Asp Ile Cys
625                 630                 635                 640 
Asn Asn Pro Ala Met Glu Ala Glu Ile Leu Lys Glu Ile Arg Glu Ala
                645                 650                 655     
Ala Asn Ala Met Lys Leu Glu Arg Phe Glu Ile Pro Ile Lys Val Arg
            660                 665                 670         
Leu Ser Pro Glu Pro Trp Thr Pro Glu Thr Gly Leu Val Thr Asp Ala
        675                 680                 685             
Phe Lys Leu Lys Arg Lys Glu Leu Arg Asn His Tyr Leu Lys Asp Ile
    690                 695                 700                 
Glu Arg Met Tyr Gly Gly Lys
705                 710     


<210> 1386
<211> 1437
<212> PRT
<213> Homo sapiens

<400> 1386
Met Asp Phe Ser Phe Ser Phe Met Gln Gly Ile Met Gly Asn Thr Ile
 1               5                  10                  15      
Gln Gln Pro Pro Gln Leu Ile Asp Ser Ala Asn Ile Arg Gln Glu Asp
            20                  25                  30          
Ala Phe Asp Asn Asn Ser Asp Ile Ala Glu Asp Gly Gly Gln Thr Pro
        35                  40                  45              
Tyr Glu Ala Thr Leu Gln Gln Gly Phe Gln Tyr Pro Ala Thr Thr Glu
    50                  55                  60                  
Asp Leu Pro Pro Leu Thr Asn Gly Tyr Pro Ser Ser Ile Ser Val Tyr
65                  70                  75                  80  
Glu Thr Gln Thr Lys Tyr Gln Ser Tyr Asn Gln Tyr Pro Asn Gly Ser
                85                  90                  95      
Ala Asn Gly Phe Gly Ala Val Arg Asn Phe Ser Pro Thr Asp Tyr Tyr
            100                 105                 110         
His Ser Glu Ile Pro Asn Thr Arg Pro His Glu Ile Leu Glu Lys Pro
        115                 120                 125             
Ser Pro Pro Gln Pro Pro Pro Pro Pro Ser Val Pro Gln Thr Val Ile
    130                 135                 140                 
Pro Lys Lys Thr Gly Ser Pro Glu Ile Lys Leu Lys Ile Thr Lys Thr
145                 150                 155                 160 
Ile Gln Asn Gly Arg Glu Leu Phe Glu Ser Ser Leu Cys Gly Asp Leu
                165                 170                 175     
Leu Asn Glu Val Gln Ala Ser Glu His Thr Lys Ser Lys His Glu Ser
            180                 185                 190         
Arg Lys Glu Lys Arg Lys Lys Ser Asn Lys His Asp Ser Ser Arg Ser
        195                 200                 205             
Glu Glu Arg Lys Ser His Lys Ile Pro Lys Leu Glu Pro Glu Glu Gln
    210                 215                 220                 
Asn Arg Pro Asn Glu Arg Val Asp Thr Val Ser Glu Lys Pro Arg Glu
225                 230                 235                 240 
Glu Pro Val Leu Lys Glu Glu Ala Pro Val Gln Pro Ile Leu Ser Ser
                245                 250                 255     
Val Pro Thr Thr Glu Val Ser Thr Gly Val Lys Phe Gln Val Gly Asp
            260                 265                 270         
Leu Val Trp Ser Lys Val Gly Thr Tyr Pro Trp Trp Pro Cys Met Val
        275                 280                 285             
Ser Ser Asp Pro Gln Leu Glu Val His Thr Lys Ile Asn Thr Arg Gly
    290                 295                 300                 
Ala Arg Glu Tyr His Val Gln Phe Phe Ser Asn Gln Pro Glu Arg Ala
305                 310                 315                 320 
Trp Val His Glu Lys Arg Val Arg Glu Tyr Lys Gly His Lys Gln Tyr
                325                 330                 335     
Glu Glu Leu Leu Ala Glu Ala Thr Lys Gln Ala Ser Asn His Ser Glu
            340                 345                 350         
Lys Gln Lys Ile Arg Lys Pro Arg Pro Gln Arg Glu Arg Ala Gln Trp
        355                 360                 365             
Asp Ile Gly Ile Ala His Ala Glu Lys Ala Leu Lys Met Thr Arg Glu
    370                 375                 380                 
Glu Arg Ile Glu Gln Tyr Thr Phe Ile Tyr Ile Asp Lys Gln Pro Glu
385                 390                 395                 400 
Glu Ala Leu Ser Gln Ala Lys Lys Ser Val Ala Ser Lys Thr Glu Val
                405                 410                 415     
Lys Lys Thr Arg Arg Pro Arg Ser Val Leu Asn Thr Gln Pro Glu Gln
            420                 425                 430         
Thr Asn Ala Gly Glu Val Ala Ser Ser Leu Ser Ser Thr Glu Ile Arg
        435                 440                 445             
Arg His Ser Gln Arg Arg His Thr Ser Ala Glu Glu Glu Glu Pro Pro
    450                 455                 460                 
Pro Val Lys Ile Ala Trp Lys Thr Ala Ala Ala Arg Lys Ser Leu Pro
465                 470                 475                 480 
Ala Ser Ile Thr Met His Lys Gly Ser Leu Asp Leu Gln Lys Cys Asn
                485                 490                 495     
Met Ser Pro Val Val Lys Ile Glu Gln Val Phe Ala Leu Gln Asn Ala
            500                 505                 510         
Thr Gly Asp Gly Lys Phe Ile Asp Gln Phe Val Tyr Ser Thr Lys Gly
        515                 520                 525             
Ile Gly Asn Lys Thr Glu Ile Ser Val Arg Gly Gln Asp Arg Leu Ile
    530                 535                 540                 
Ile Ser Thr Pro Asn Gln Arg Asn Glu Lys Pro Thr Gln Ser Val Ser
545                 550                 555                 560 
Ser Pro Glu Ala Thr Ser Gly Ser Thr Gly Ser Val Glu Lys Lys Gln
                565                 570                 575     
Gln Arg Arg Ser Ile Arg Thr Arg Ser Glu Ser Glu Lys Ser Thr Glu
            580                 585                 590         
Val Val Pro Lys Lys Lys Ile Lys Lys Glu Gln Val Glu Thr Val Pro
        595                 600                 605             
Gln Ala Thr Val Lys Thr Gly Leu Gln Lys Gly Ala Ser Glu Ile Ser
    610                 615                 620                 
Asp Ser Cys Lys Pro Leu Lys Lys Arg Ser Arg Ala Ser Thr Asp Val
625                 630                 635                 640 
Glu Met Thr Ser Ser Ala Tyr Arg Asp Thr Ser Asp Ser Asp Ser Arg
                645                 650                 655     
Gly Leu Ser Asp Leu Gln Val Gly Phe Gly Lys Gln Val Asp Ser Pro
            660                 665                 670         
Ser Ala Thr Ala Asp Ala Asp Val Ser Asp Val Gln Ser Met Asp Ser
        675                 680                 685             
Ser Leu Ser Arg Arg Gly Thr Gly Met Ser Lys Lys Asp Thr Val Cys
    690                 695                 700                 
Gln Ile Cys Glu Ser Ser Gly Asp Ser Leu Ile Pro Cys Glu Gly Glu
705                 710                 715                 720 
Cys Cys Lys His Phe His Leu Glu Cys Leu Gly Leu Ala Ser Leu Pro
                725                 730                 735     
Asp Ser Lys Phe Ile Cys Met Glu Cys Lys Thr Gly Gln His Pro Cys
            740                 745                 750         
Phe Ser Cys Lys Val Ser Gly Lys Asp Val Lys Arg Cys Ser Val Gly
        755                 760                 765             
Ala Cys Gly Lys Phe Tyr His Glu Ala Cys Val Arg Lys Phe Pro Thr
    770                 775                 780                 
Ala Ile Phe Glu Ser Lys Gly Phe Arg Cys Pro Gln His Cys Cys Ser
785                 790                 795                 800 
Ala Cys Ser Met Glu Lys Asp Ile His Lys Ala Ser Lys Gly Arg Met
                805                 810                 815     
Met Arg Cys Leu Arg Cys Pro Val Ala Tyr His Ser Glu Asp Ala Cys
            820                 825                 830         
Ile Ala Ala Gly Ser Met Leu Val Ser Ser Tyr Ile Leu Ile Cys Ser
        835                 840                 845             
Asn His Ser Lys Arg Ser Ser Asn Ser Ser Ala Val Asn Val Gly Phe
    850                 855                 860                 
Cys Phe Val Cys Ala Arg Gly Leu Ile Val Gln Asp His Ser Asp Pro
865                 870                 875                 880 
Met Phe Ser Ser Tyr Ala Tyr Lys Ser His Tyr Leu Leu Asn Glu Ser
                885                 890                 895     
Asn Arg Ala Glu Leu Met Lys Leu Pro Met Ile Pro Ser Ser Ser Ala
            900                 905                 910         
Ser Lys Lys Lys Cys Glu Lys Gly Gly Arg Leu Leu Cys Cys Glu Ser
        915                 920                 925             
Cys Pro Ala Ser Phe His Pro Glu Cys Leu Ser Ile Glu Met Pro Glu
    930                 935                 940                 
Gly Cys Trp Asn Cys Asn Asp Cys Lys Ala Gly Lys Lys Leu His Tyr
945                 950                 955                 960 
Lys Gln Ile Val Trp Val Lys Leu Gly Asn Tyr Arg Trp Trp Pro Ala
                965                 970                 975     
Glu Ile Cys Asn Pro Arg Ser Val Pro Leu Asn Ile Gln Gly Leu Lys
            980                 985                 990         
His Asp Leu Gly Asp Phe Pro Val Phe Phe Phe Gly Ser His Asp Tyr
        995                 1000                1005            
Tyr Trp Val His Gln Gly Arg Val Phe Pro Tyr Val Glu Gly Asp Lys
    1010                1015                1020                
Ser Phe Ala Glu Gly Gln Thr Ser Ile Asn Lys Thr Phe Lys Lys Ala
1025                1030                1035                1040
Leu Glu Glu Ala Ala Lys Arg Phe Gln Glu Leu Lys Ala Gln Arg Glu
                1045                1050                1055    
Ser Lys Glu Ala Leu Glu Ile Glu Lys Asn Ser Arg Lys Pro Pro Pro
            1060                1065                1070        
Tyr Lys His Ile Lys Ala Asn Lys Val Ile Gly Lys Val Gln Ile Gln
        1075                1080                1085            
Val Ala Asp Leu Ser Glu Ile Pro Arg Cys Asn Cys Lys Pro Ala Asp
    1090                1095                1100                
Glu Asn Pro Cys Gly Leu Glu Ser Glu Cys Leu Asn Arg Met Leu Gln
1105                1110                1115                1120
Tyr Glu Cys His Pro Gln Val Cys Pro Ala Gly Asp Arg Cys Gln Asn
                1125                1130                1135    
Gln Cys Phe Thr Lys Arg Leu Tyr Pro Asp Ala Glu Ile Ile Lys Thr
            1140                1145                1150        
Glu Arg Arg Gly Trp Gly Leu Arg Thr Lys Arg Ser Ile Lys Lys Gly
        1155                1160                1165            
Glu Phe Val Asn Glu Tyr Val Gly Glu Leu Ile Asp Glu Glu Glu Cys
    1170                1175                1180                
Arg Leu Arg Ile Lys Arg Ala His Glu Asn Ser Val Thr Asn Phe Tyr
1185                1190                1195                1200
Met Leu Thr Val Thr Lys Asp Arg Ile Ile Asp Ala Gly Pro Lys Gly
                1205                1210                1215    
Asn Tyr Ser Arg Phe Met Asn His Ser Cys Asn Pro Asn Cys Glu Thr
            1220                1225                1230        
Gln Lys Trp Thr Val Asn Gly Asp Val Arg Val Gly Leu Phe Ala Leu
        1235                1240                1245            
Cys Asp Ile Pro Ala Gly Met Glu Leu Thr Phe Asn Tyr Asn Leu Asp
    1250                1255                1260                
Cys Leu Gly Asn Gly Arg Thr Glu Cys His Cys Gly Ala Asp Asn Cys
1265                1270                1275                1280
Ser Gly Phe Leu Gly Val Arg Pro Lys Ser Ala Cys Ala Ser Thr Asn
                1285                1290                1295    
Glu Glu Lys Ala Lys Asn Ala Lys Leu Lys Gln Lys Arg Arg Lys Ile
            1300                1305                1310        
Lys Thr Glu Pro Lys Gln Met His Glu Asp Tyr Cys Phe Gln Cys Gly
        1315                1320                1325            
Asp Gly Gly Glu Leu Val Met Cys Asp Lys Lys Asp Cys Pro Lys Ala
    1330                1335                1340                
Tyr His Leu Leu Cys Leu Asn Leu Thr Gln Pro Pro Tyr Gly Lys Trp
1345                1350                1355                1360
Glu Cys Pro Trp His Gln Cys Asp Glu Cys Ser Ser Ala Ala Val Ser
                1365                1370                1375    
Phe Cys Glu Phe Cys Pro His Ser Phe Cys Lys Asp His Glu Lys Gly
            1380                1385                1390        
Ala Leu Val Pro Ser Ala Leu Glu Gly Arg Leu Cys Cys Ser Glu His
        1395                1400                1405            
Asp Pro Met Ala Pro Val Ser Pro Glu Tyr Trp Ser Lys Ile Lys Cys
    1410                1415                1420                
Lys Trp Glu Ser Gln Asp His Gly Glu Glu Val Lys Glu
1425                1430                1435        


<210> 1387
<211> 276
<212> PRT
<213> Homo sapiens

<400> 1387
Ala Asp Leu Ser Val Thr Glu Ala Ser Ser Ser Asp Ser Arg Gly Glu
 1               5                  10                  15      
Arg Ala Glu Leu Tyr Ala Gln Val Glu Glu Gly Leu Leu Gly Gly Glu
            20                  25                  30          
Ala Ser Tyr Leu Gly Pro Pro Leu Thr Pro Glu Lys Asp Asp Ala Leu
        35                  40                  45              
His Gln Ala Thr Ala Val Ala Asn Leu Arg Ala Ala Leu Met Ser Lys
    50                  55                  60                  
Asn Ser Leu Leu Ser Leu Lys Ala Asp Val Leu Gly Asp Asp Gly Ser
65                  70                  75                  80  
Leu Leu Phe Glu Tyr Leu Pro Arg Gly Ala His Ser Leu Ser Leu Asn
                85                  90                  95      
Glu Phe Thr Val Ile Arg Lys Lys Phe Lys Cys Pro Tyr Cys Ser Phe
            100                 105                 110         
Ser Ala Met His Gln Cys Ile Leu Lys Arg His Met Arg Ser His Thr
        115                 120                 125             
Gly Glu Arg Pro Tyr Pro Cys Glu Ile Cys Gly Lys Lys Phe Thr Arg
    130                 135                 140                 
Arg Glu His Met Lys Arg His Thr Leu Val His Ser Lys Asp Lys Lys
145                 150                 155                 160 
Tyr Val Cys Lys Val Cys Ser Arg Val Phe Met Ser Ala Ala Ser Val
                165                 170                 175     
Gly Ile Arg His Gly Ser Arg Arg His Gly Val Cys Thr Asp Cys Ala
            180                 185                 190         
Gly Arg Gly Met Ala Gly Pro Leu Asp His Gly Gly Gly Gly Gly Glu
        195                 200                 205             
Gly Ser Pro Glu Ala Leu Phe Pro Gly Asp Gly Pro Tyr Leu Glu Asp
    210                 215                 220                 
Pro Glu Asp Pro Arg Gly Glu Ala Glu Glu Leu Gly Glu Asp Asp Glu
225                 230                 235                 240 
Gly Leu Ala Pro Glu Asp Ala Leu Leu Ala Asp Asp Lys Asp Glu Glu
                245                 250                 255     
Asp Ser Pro Arg Pro Arg Ser Pro Pro Gly Gly Pro Asp Lys Asp Phe
            260                 265                 270         
Ala Trp Leu Ser
        275     


<210> 1388
<211> 216
<212> PRT
<213> Homo sapiens

<400> 1388
Met Lys Ser Ile Ser Leu Leu Arg Tyr Gln Glu Glu Ser Lys Thr Leu
 1               5                  10                  15      
Ser Leu Val Ser Arg Asp Ala Lys Pro Leu Glu Val Tyr Ser Val Asp
            20                  25                  30          
Phe Met Val Asp Asn Ala Gln Leu Gly Phe Leu Val Ser Asp Arg Asp
        35                  40                  45              
Arg Asn Leu Met Val Tyr Met Tyr Leu Pro Glu Ala Lys Glu Ser Phe
    50                  55                  60                  
Gly Gly Met Arg Leu Leu Arg Arg Ala Asp Phe His Val Gly Ala His
65                  70                  75                  80  
Val Asn Thr Phe Trp Arg Thr Pro Cys Arg Gly Ala Thr Glu Gly Leu
                85                  90                  95      
Ser Lys Lys Ser Val Val Trp Glu Asn Lys His Ile Thr Trp Phe Ala
            100                 105                 110         
Thr Leu Asp Gly Gly Ile Gly Leu Leu Leu Pro Met Gln Glu Lys Thr
        115                 120                 125             
Tyr Arg Arg Leu Leu Met Leu Gln Asn Ala Leu Thr Thr Met Leu Pro
    130                 135                 140                 
His His Ala Gly Leu Asn Pro Arg Ala Phe Arg Met Leu His Val Asp
145                 150                 155                 160 
Arg Arg Thr Leu Gln Asn Ala Val Arg Asn Val Leu Asp Gly Glu Leu
                165                 170                 175     
Leu Asn Arg Tyr Leu Tyr Leu Ser Thr Met Glu Arg Ser Glu Leu Ala
            180                 185                 190         
Lys Lys Ile Gly Thr Thr Pro Asp Ile Ile Leu Asp Asp Leu Leu Glu
        195                 200                 205             
Thr Asp Arg Val Thr Ala His Phe
    210                 215     


<210> 1389
<211> 521
<212> PRT
<213> Homo sapiens

<400> 1389
His Val Leu Gln Phe Met Tyr Tyr Gly Thr Ile Glu Leu Ser Met Asn
 1               5                  10                  15      
Thr Val His Glu Ile Leu Gln Ala Ala Met Tyr Val Gln Leu Ile Glu
            20                  25                  30          
Val Val Lys Phe Cys Cys Ser Phe Leu Leu Ala Lys Ile Cys Leu Glu
        35                  40                  45              
Asn Cys Ala Glu Ile Met Arg Leu Leu Asp Asp Phe Gly Val Asn Ile
    50                  55                  60                  
Glu Gly Val Arg Glu Lys Leu Asp Thr Phe Leu Leu Asp Asn Phe Val
65                  70                  75                  80  
Pro Leu Met Ser Arg Pro Asp Phe Leu Ser Tyr Leu Ser Phe Glu Lys
                85                  90                  95      
Leu Met Ser Tyr Leu Asp Asn Asp His Leu Ser Arg Phe Pro Glu Ile
            100                 105                 110         
Glu Leu Tyr Glu Ala Val Gln Ser Trp Leu Arg His Asp Arg Arg Arg
        115                 120                 125             
Trp Arg His Thr Asp Thr Ile Ile Gln Asn Ile Arg Phe Cys Leu Met
    130                 135                 140                 
Thr Pro Thr Ser Val Phe Glu Lys Val Lys Thr Ser Glu Phe Tyr Arg
145                 150                 155                 160 
Tyr Ser Arg Gln Leu Arg Tyr Glu Val Asp Gln Ala Leu Asn Tyr Phe
                165                 170                 175     
Gln Asn Val His Gln Gln Pro Leu Leu Asp Met Lys Ser Ser Arg Ile
            180                 185                 190         
Arg Ser Ala Lys Pro Gln Thr Thr Val Phe Arg Gly Met Ile Gly His
        195                 200                 205             
Ser Met Val Asn Ser Lys Ile Leu Leu Leu Lys Lys Pro Arg Val Trp
    210                 215                 220                 
Trp Glu Leu Glu Gly Pro Gln Val Pro Leu Arg Pro Asp Cys Leu Ala
225                 230                 235                 240 
Ile Val Asn Asn Phe Val Phe Leu Leu Gly Gly Glu Glu Leu Gly Pro
                245                 250                 255     
Asp Gly Glu Phe His Ala Ser Ser Lys Val Phe Arg Tyr Asp Pro Arg
            260                 265                 270         
Gln Asn Ser Trp Leu Gln Met Ala Asp Met Ser Val Pro Arg Ser Glu
        275                 280                 285             
Phe Ala Val Gly Val Ile Gly Lys Phe Ile Tyr Ala Val Ala Gly Arg
    290                 295                 300                 
Thr Arg Asp Glu Thr Phe Tyr Ser Thr Glu Arg Tyr Asp Ile Thr Asn
305                 310                 315                 320 
Asp Lys Trp Glu Phe Val Asp Pro Tyr Pro Val Asn Lys Tyr Gly His
                325                 330                 335     
Glu Gly Thr Val Leu Asn Asn Lys Leu Phe Ile Thr Gly Gly Ile Thr
            340                 345                 350         
Ser Ser Ser Thr Ser Lys Gln Val Cys Val Phe Asp Pro Ser Lys Glu
        355                 360                 365             
Gly Thr Ile Glu Gln Arg Thr Arg Arg Thr Gln Val Val Thr Asn Cys
    370                 375                 380                 
Trp Glu Asn Lys Ser Lys Met Asn Tyr Ala Arg Cys Phe His Lys Met
385                 390                 395                 400 
Ile Ser Tyr Asn Gly Lys Leu Tyr Val Phe Gly Gly Val Cys Val Ile
                405                 410                 415     
Leu Arg Ala Ser Phe Glu Ser Gln Gly Cys Pro Ser Thr Glu Val Tyr
            420                 425                 430         
Asn Pro Glu Thr Asp Gln Trp Thr Ile Leu Ala Ser Met Pro Ile Gly
        435                 440                 445             
Arg Ser Gly His Gly Val Thr Val Leu Asp Lys Gln Ile Met Val Leu
    450                 455                 460                 
Gly Gly Leu Cys Tyr Asn Gly His Tyr Ser Asp Ser Ile Leu Thr Phe
465                 470                 475                 480 
Asp Pro Asp Glu Asn Lys Trp Lys Glu Asp Glu Tyr Pro Arg Met Pro
                485                 490                 495     
Cys Lys Leu Asp Gly Leu Gln Val Cys Asn Leu His Phe Pro Asp Tyr
            500                 505                 510         
Val Leu Asp Glu Val Arg Arg Cys Asn
        515                 520     


<210> 1390
<211> 1536
<212> PRT
<213> Homo sapiens

<400> 1390
Gly Trp Thr Ser His Leu Ser Asn Cys Gly Glu Ser Asn Arg Pro Pro
 1               5                  10                  15      
Lys Glu Arg Ser Cys Phe Arg Val Cys Asp Trp His Ser Asp Leu Phe
            20                  25                  30          
Gln Trp Glu Val Ser Asp Trp His His Cys Val Leu Val Pro Tyr Ala
        35                  40                  45              
Arg Gly Glu Val Lys Pro Arg Thr Ala Glu Cys Val Thr Ala Gln His
    50                  55                  60                  
Gly Leu Gln His Arg Met Val Arg Cys Ile Gln Lys Leu Asn Arg Thr
65                  70                  75                  80  
Val Val Ala Asn Glu Ile Cys Glu His Phe Ala Leu Gln Pro Pro Thr
                85                  90                  95      
Glu Gln Ala Cys Leu Ile Pro Cys Pro Arg Asp Cys Val Val Ser Glu
            100                 105                 110         
Phe Leu Pro Trp Ser Asn Cys Ser Lys Gly Cys Gly Lys Lys Leu Gln
        115                 120                 125             
His Arg Thr Arg Ala Val Ile Ala Pro Pro Leu Phe Gly Gly Leu Gln
    130                 135                 140                 
Cys Pro Asn Leu Thr Glu Ser Arg Ala Cys Asp Ala Pro Ile Ser Cys
145                 150                 155                 160 
Pro Leu Gly Glu Glu Glu Tyr Thr Phe Ser Leu Lys Val Gly Pro Trp
                165                 170                 175     
Ser Lys Cys Arg Leu Pro His Leu Lys Glu Ile Asn Pro Ser Gly Arg
            180                 185                 190         
Thr Val Leu Asp Phe Asn Ser Asp Ser Asn Glu Arg Val Thr Phe Lys
        195                 200                 205             
His Gln Ser Tyr Lys Ala His His His Ser Lys Ser Trp Ala Ile Glu
    210                 215                 220                 
Ile Gly Tyr Gln Thr Arg Gln Val Ser Cys Thr Arg Ser Asp Gly Gln
225                 230                 235                 240 
Asn Ala Met Leu Ser Leu Cys Leu Gln Asp Ser Phe Pro Leu Thr Val
                245                 250                 255     
Gln Ser Cys Ile Met Pro Lys Asp Cys Glu Thr Ser Gln Trp Ser Ser
            260                 265                 270         
Trp Ser Pro Cys Ser Lys Thr Cys Arg Ser Gly Ser Leu Leu Pro Gly
        275                 280                 285             
Phe Arg Ser Arg Ser Arg Asn Val Lys His Met Ala Ile Gly Gly Gly
    290                 295                 300                 
Lys Glu Cys Pro Glu Leu Leu Glu Lys Glu Ala Cys Ile Val Glu Gly
305                 310                 315                 320 
Glu Leu Leu Gln Gln Cys Pro Arg Tyr Ser Trp Arg Thr Ser Glu Trp
                325                 330                 335     
Lys Glu Cys Gln Val Ser Leu Leu Leu Glu Gln Gln Asp Pro His Trp
            340                 345                 350         
His Val Thr Gly Pro Val Cys Gly Gly Gly Ile Gln Thr Arg Glu Val
        355                 360                 365             
Tyr Cys Ala Gln Ser Val Pro Ala Ala Ala Ala Leu Arg Ala Lys Glu
    370                 375                 380                 
Val Ser Arg Pro Val Glu Lys Ala Leu Cys Val Gly Pro Ala Pro Leu
385                 390                 395                 400 
Pro Ser Gln Leu Cys Asn Ile Pro Cys Ser Thr Asp Cys Ile Val Ser
                405                 410                 415     
Ser Trp Ser Ala Trp Gly Leu Cys Ile His Glu Asn Cys His Glu Pro
            420                 425                 430         
Gln Gly Lys Lys Gly Phe Arg Thr Arg Gln Arg His Val Leu Met Glu
        435                 440                 445             
Ser Thr Gly Pro Ala Gly His Cys Pro His Leu Val Glu Ser Val Pro
    450                 455                 460                 
Cys Glu Asp Pro Met Cys Tyr Arg Trp Leu Ala Ser Glu Gly Ile Cys
465                 470                 475                 480 
Phe Pro Asp His Gly Lys Cys Gly Leu Gly His Arg Ile Leu Lys Ala
                485                 490                 495     
Val Cys Gln Asn Asp Arg Gly Glu Asp Val Ser Gly Ser Leu Cys Pro
            500                 505                 510         
Val Pro Pro Pro Pro Glu Arg Lys Ser Cys Glu Ile Pro Cys Arg Met
        515                 520                 525             
Asp Cys Val Leu Ser Glu Trp Thr Glu Trp Ser Ser Cys Ser Gln Ser
    530                 535                 540                 
Cys Ser Asn Lys Asn Ser Asp Gly Lys Gln Thr Arg Ser Arg Thr Ile
545                 550                 555                 560 
Leu Ala Leu Ala Gly Glu Gly Gly Lys Pro Cys Pro Pro Ser Gln Ala
                565                 570                 575     
Leu Gln Glu His Arg Leu Cys Asn Asp His Ser Cys Met Gln Leu His
            580                 585                 590         
Trp Glu Thr Ser Pro Trp Gly Pro Cys Ser Glu Asp Thr Leu Val Thr
        595                 600                 605             
Ala Leu Asn Ala Thr Ile Gly Trp Asn Gly Glu Ala Thr Cys Gly Val
    610                 615                 620                 
Gly Ile Gln Thr Arg Arg Val Phe Cys Val Lys Ser His Val Gly Gln
625                 630                 635                 640 
Val Met Thr Lys Arg Cys Pro Asp Ser Thr Arg Pro Glu Thr Val Arg
                645                 650                 655     
Pro Cys Phe Leu Pro Cys Lys Lys Asp Cys Ile Val Thr Ala Phe Ser
            660                 665                 670         
Glu Trp Thr Pro Cys Pro Arg Met Cys Gln Ala Gly Asn Ala Thr Val
        675                 680                 685             
Lys Gln Ser Arg Tyr Arg Ile Ile Ile Gln Glu Ala Ala Asn Gly Gly
    690                 695                 700                 
Gln Glu Cys Pro Asp Thr Leu Tyr Glu Glu Arg Glu Cys Glu Asp Val
705                 710                 715                 720 
Ser Leu Cys Pro Val Tyr Arg Trp Lys Pro Gln Lys Trp Ser Pro Cys
                725                 730                 735     
Ile Leu Val Pro Glu Ser Val Trp Gln Gly Ile Thr Gly Ser Ser Glu
            740                 745                 750         
Ala Cys Gly Lys Gly Leu Gln Thr Arg Ala Val Ser Cys Ile Ser Asp
        755                 760                 765             
Asp Asn Arg Ser Ala Glu Met Met Glu Cys Leu Lys Gln Thr Asn Gly
    770                 775                 780                 
Met Pro Leu Leu Val Gln Glu Cys Thr Val Pro Cys Arg Glu Asp Cys
785                 790                 795                 800 
Thr Phe Thr Ala Trp Ser Lys Phe Thr Pro Cys Ser Thr Asn Cys Glu
                805                 810                 815     
Ala Thr Lys Ser Arg Arg Arg Gln Leu Thr Gly Lys Ser Arg Lys Lys
            820                 825                 830         
Glu Lys Cys Gln Asp Ser Asp Leu Tyr Pro Leu Val Glu Thr Glu Leu
        835                 840                 845             
Cys Pro Cys Asp Glu Phe Ile Ser Gln Pro Tyr Gly Asn Trp Ser Asp
    850                 855                 860                 
Cys Ile Leu Pro Glu Gly Arg Arg Glu Pro His Arg Gly Leu Arg Val
865                 870                 875                 880 
Gln Ala Asp Ser Lys Glu Cys Gly Glu Gly Leu Arg Phe Arg Ala Val
                885                 890                 895     
Ala Cys Ser Asp Lys Asn Gly Arg Pro Val Asp Pro Ser Phe Cys Ser
            900                 905                 910         
Ser Ser Gly Tyr Ile Gln Glu Lys Cys Val Ile Pro Cys Pro Phe Asp
        915                 920                 925             
Cys Lys Leu Ser Asp Trp Ser Ser Trp Gly Ser Cys Ser Ser Ser Cys
    930                 935                 940                 
Gly Ile Gly Val Arg Ile Arg Ser Lys Trp Leu Lys Glu Lys Pro Tyr
945                 950                 955                 960 
Asn Gly Gly Arg Pro Cys Pro Lys Leu Asp Leu Lys Asn Gln Ala Gln
                965                 970                 975     
Val His Glu Ala Val Pro Cys Tyr Ser Glu Cys Asn Gln Tyr Ser Trp
            980                 985                 990         
Val Val Glu His Trp Ser Ser Cys Lys Ile Asn Asn Glu Leu Arg Ser
        995                 1000                1005            
Leu Arg Cys Gly Gly Gly Thr Gln Ser Arg Lys Ile Arg Cys Val Asn
    1010                1015                1020                
Thr Ala Asp Gly Glu Gly Gly Ala Val Asp Ser Asn Leu Cys Asn Gln
1025                1030                1035                1040
Asp Glu Ile Pro Pro Glu Thr Gln Ser Cys Ser Leu Met Cys Pro Asn
                1045                1050                1055    
Glu Cys Val Met Ser Glu Trp Gly Leu Trp Ser Lys Cys Pro Gln Ser
            1060                1065                1070        
Cys Asp Pro His Thr Met Gln Arg Arg Thr Arg His Leu Leu Arg Pro
        1075                1080                1085            
Ser Leu Asn Ser Arg Thr Cys Ala Glu Asp Ser Gln Val Gln Pro Cys
    1090                1095                1100                
Leu Leu Asn Glu Asn Cys Phe Gln Phe Gln Tyr Asn Leu Thr Glu Trp
1105                1110                1115                1120
Ser Thr Cys Gln Leu Ser Glu Asn Ala Pro Cys Gly Gln Gly Val Arg
                1125                1130                1135    
Thr Arg Leu Leu Ser Cys Val Cys Ser Asp Gly Lys Pro Val Ser Met
            1140                1145                1150        
Asp Gln Cys Glu Gln His Asn Leu Glu Lys Pro Gln Arg Met Ser Ile
        1155                1160                1165            
Pro Cys Leu Val Glu Cys Val Val Asn Cys Gln Leu Ser Gly Trp Thr
    1170                1175                1180                
Ala Trp Thr Glu Cys Ser Gln Thr Cys Gly His Gly Gly Arg Met Ser
1185                1190                1195                1200
Arg Thr Arg Phe Ile Ile Met Pro Thr Gln Gly Glu Gly Arg Pro Cys
                1205                1210                1215    
Pro Thr Glu Leu Thr Gln Glu Lys Thr Cys Pro Val Thr Pro Cys Tyr
            1220                1225                1230        
Ser Trp Val Leu Gly Asn Trp Ser Ala Cys Lys Leu Glu Gly Gly Asp
        1235                1240                1245            
Cys Gly Glu Gly Val Gln Ile Arg Ser Leu Ser Cys Met Val His Ser
    1250                1255                1260                
Gly Ser Ile Ser His Ala Ala Gly Arg Val Glu Asp Ala Leu Cys Gly
1265                1270                1275                1280
Glu Met Pro Phe Gln Asp Ser Ile Leu Lys Gln Leu Cys Ser Val Pro
                1285                1290                1295    
Cys Pro Gly Asp Cys His Leu Thr Glu Trp Ser Glu Trp Ser Thr Cys
            1300                1305                1310        
Glu Leu Thr Cys Ile Asp Gly Arg Ser Phe Glu Thr Val Gly Arg Gln
        1315                1320                1325            
Ser Arg Ser Arg Thr Phe Ile Ile Gln Ser Phe Glu Asn Gln Asp Ser
    1330                1335                1340                
Cys Pro Gln Gln Val Leu Glu Thr Arg Pro Cys Thr Gly Gly Lys Cys
1345                1350                1355                1360
Tyr His Tyr Thr Trp Lys Ala Ser Leu Trp Asn Asn Asn Glu Arg Thr
                1365                1370                1375    
Val Trp Cys Gln Arg Ser Asp Gly Val Asn Val Thr Gly Gly Cys Ser
            1380                1385                1390        
Pro Gln Ala Arg Pro Ala Ala Ile Arg Gln Cys Ile Pro Ala Cys Arg
        1395                1400                1405            
Lys Pro Phe Ser Tyr Cys Thr Gln Gly Gly Val Cys Gly Cys Glu Lys
    1410                1415                1420                
Gly Tyr Thr Glu Ile Met Arg Ser Asn Gly Phe Leu Asp Tyr Cys Met
1425                1430                1435                1440
Lys Val Pro Gly Ser Glu Asp Lys Lys Ala Asp Val Lys Asn Leu Ser
                1445                1450                1455    
Gly Lys Asn Arg Pro Val Asn Ser Lys Ile His Asp Ile Phe Lys Gly
            1460                1465                1470        
Trp Ser Leu Gln Pro Leu Asp Pro Asp Gly Arg Val Lys Ile Trp Val
        1475                1480                1485            
Tyr Gly Val Ser Gly Gly Ala Phe Leu Ile Met Ile Phe Leu Ile Phe
    1490                1495                1500                
Thr Ser Tyr Leu Val Cys Lys Lys Pro Lys Pro His Gln Ser Thr Pro
1505                1510                1515                1520
Pro Gln Gln Lys Pro Leu Thr Leu Ala Tyr Asp Gly Asp Leu Asp Met
                1525                1530                1535    


<210> 1391
<211> 570
<212> PRT
<213> Homo sapiens

<400> 1391
Asp Phe Asp Leu Gly His Ile Glu Asn Gln Gly Gln Asp Trp Thr Gly
 1               5                  10                  15      
Pro Tyr Asn Trp Ala Ser Thr Met Ala Gly Thr Lys Asn Lys Thr Arg
            20                  25                  30          
Ala Gln Ala Lys Thr Glu Lys Lys Ala Ala Ile Gln Ala Lys Ala Gly
        35                  40                  45              
Ala Glu Arg Glu Ala Thr Gly Val Val Arg Pro Val Ala Lys Thr Arg
    50                  55                  60                  
Ala Lys Ala Lys Ala Lys Thr Gly Ser Lys Thr Asp Ala Val Ala Glu
65                  70                  75                  80  
Met Lys Ala Val Ser Lys Asn Lys Val Val Ala Glu Thr Lys Glu Gly
                85                  90                  95      
Ala Leu Ser Glu Pro Lys Thr Leu Gly Lys Ala Met Gly Asp Phe Thr
            100                 105                 110         
Pro Lys Ala Gly Asn Glu Ser Thr Ser Ser Thr Cys Lys Asn Glu Ala
        115                 120                 125             
Gly Thr Asp Ala Trp Phe Trp Ala Gly Glu Glu Ala Thr Ile Asn Ser
    130                 135                 140                 
Trp Phe Trp Asn Gly Glu Glu Ala Gly Asn Ser Phe Ser Thr Lys Asn
145                 150                 155                 160 
Asp Lys Pro Glu Ile Gly Ala Gln Val Cys Ala Glu Glu Leu Glu Pro
                165                 170                 175     
Ala Ala Gly Ala Asp Cys Lys Pro Arg Ser Gly Ala Glu Glu Glu Glu
            180                 185                 190         
Glu Glu Asn Val Ile Gly Asn Trp Phe Trp Glu Gly Asp Asp Thr Ser
        195                 200                 205             
Phe Asp Pro Asn Pro Lys Pro Val Ser Arg Ile Val Lys Pro Gln Pro
    210                 215                 220                 
Val Tyr Glu Ile Asn Glu Lys Asn Arg Pro Lys Asp Trp Ser Glu Val
225                 230                 235                 240 
Thr Ile Trp Pro Asn Ala Pro Ala Val Thr Pro Ala Val Leu Gly Phe
                245                 250                 255     
Arg Ser Gln Ala Pro Ser Glu Ala Ser Pro Pro Ser Tyr Ile Val Leu
            260                 265                 270         
Ala Ser Ala Glu Glu Asn Ala Cys Ser Leu Pro Val Ala Thr Ala Cys
        275                 280                 285             
Arg Pro Ser Arg Asn Thr Arg Ser Cys Ser Gln Pro Ile Pro Glu Cys
    290                 295                 300                 
Arg Phe Asp Ser Asp Pro Cys Ile Gln Thr Ile Asp Glu Ile Arg Arg
305                 310                 315                 320 
Gln Ile Arg Ile Arg Glu Val Asn Gly Ile Lys Pro Phe Ala Cys Pro
                325                 330                 335     
Cys Lys Met Glu Cys Tyr Met Asp Ser Glu Glu Phe Glu Lys Leu Val
            340                 345                 350         
Ser Leu Leu Lys Ser Thr Thr Asp Pro Leu Ile His Lys Ile Ala Arg
        355                 360                 365             
Ile Ala Met Gly Val His Asn Val His Pro Phe Ala Gln Glu Phe Ile
    370                 375                 380                 
Asn Glu Val Gly Val Val Thr Leu Ile Glu Ser Leu Leu Ser Phe Pro
385                 390                 395                 400 
Ser Pro Glu Met Arg Lys Lys Thr Val Ile Thr Leu Asn Pro Pro Ser
                405                 410                 415     
Gly Asp Glu Arg Gln Arg Lys Ile Glu Leu His Val Lys His Met Cys
            420                 425                 430         
Lys Glu Thr Met Ser Phe Pro Leu Asn Ser Pro Gly Gln Gln Ser Gly
        435                 440                 445             
Leu Lys Ile Leu Gly Gln Leu Thr Thr Asp Phe Val His His Tyr Ile
    450                 455                 460                 
Val Ala Asn Tyr Phe Ser Glu Leu Phe His Leu Leu Ser Ser Gly Asn
465                 470                 475                 480 
Cys Lys Thr Arg Asn Leu Val Leu Lys Leu Leu Leu Asn Met Ser Glu
                485                 490                 495     
Asn Pro Thr Ala Ala Arg Asp Met Ile Asn Met Lys Ala Leu Ala Ala
            500                 505                 510         
Leu Lys Leu Ile Phe Asn Gln Lys Glu Ala Lys Ala Asn Leu Val Ser
        515                 520                 525             
Gly Val Ala Ile Phe Ile Asn Ile Lys Glu His Ile Arg Lys Gly Ser
    530                 535                 540                 
Ile Val Val Val Asp His Leu Ser Tyr Asn Thr Leu Met Ala Ile Phe
545                 550                 555                 560 
Arg Glu Val Lys Glu Ile Ile Glu Thr Met
                565                 570 


<210> 1392
<211> 1165
<212> PRT
<213> Homo sapiens

<400> 1392
Glu Ala Gly Ser Ala Asp Met Ser Lys Asn Ile Ile Met Pro Glu Glu
 1               5                  10                  15      
Glu His Gln Gln Asn Ser Glu Glu Phe Gln Ile Ile Ser Gly Gln Pro
            20                  25                  30          
Ser Asp Thr Leu Lys Ser Arg Asn Ala Ala Asp Cys Ser Ile Leu Asn
        35                  40                  45              
Glu Asn Thr Asn Leu Asp Met Ser Lys Val Leu Cys Ala Ala Asp Ser
    50                  55                  60                  
Val Glu Val Glu Thr Glu Glu Glu Ser Asn Phe Asn Glu Asp His Ser
65                  70                  75                  80  
Phe Cys Glu Thr Phe Gln Gln Ala Pro Val Lys Asp Lys Val Arg Lys
                85                  90                  95      
Pro Glu Glu Met Met Ser Leu Thr Met Ser Ser Asn Tyr Gly Ser Pro
            100                 105                 110         
Ser Arg Phe Gln Asn Glu Asn Ser Gly Ser Ser Ala Leu Asn Cys Glu
        115                 120                 125             
Thr Ala Lys Lys Asn His Glu Ile Ser Asn Asp Ala Gly Glu Leu Arg
    130                 135                 140                 
Val His Cys Glu Gly Glu Gly Gly Asn Ala Gly Asp Gly Gly Gly Val
145                 150                 155                 160 
Val Pro His Arg His Leu Cys Pro Val Thr Leu Asp Gly Glu Arg Ser
                165                 170                 175     
Ala Glu Ser Pro Val Leu Val Val Thr Arg Ile Thr Arg Glu Gln Gly
            180                 185                 190         
Asn Leu Glu Ser Gly Gly Gln Asn Arg Val Ala Arg Gly His Gly Leu
        195                 200                 205             
Glu Asp Leu Lys Gly Val Gln Glu Asp Pro Val Leu Gly Asn Lys Glu
    210                 215                 220                 
Ile Leu Met Asn Ser Gln His Glu Thr Glu Phe Ile Leu Glu Glu Asp
225                 230                 235                 240 
Gly Pro Ala Ser Asp Ser Thr Val Glu Ser Ser Asp Val Tyr Glu Thr
                245                 250                 255     
Ile Ile Ser Ile Asp Asp Lys Gly Gln Ala Met Tyr Ser Phe Gly Arg
            260                 265                 270         
Phe Asp Ser Ser Ile Ile Arg Ile Lys Asn Pro Glu Asp Gly Glu Leu
        275                 280                 285             
Ile Asp Gln Ser Glu Glu Gly Leu Ile Ala Thr Gly Val Arg Ile Ser
    290                 295                 300                 
Glu Leu Pro Leu Lys Asp Cys Ala Gln Gly Val Lys Lys Lys Lys Ser
305                 310                 315                 320 
Glu Gly Ser Ser Ile Gly Glu Ser Thr Arg Ile Arg Cys Asp Asp Cys
                325                 330                 335     
Gly Phe Leu Ala Asp Gly Leu Ser Gly Leu Asn Val His Ile Ala Met
            340                 345                 350         
Lys His Pro Thr Lys Glu Lys His Phe His Cys Leu Leu Cys Gly Lys
        355                 360                 365             
Ser Phe Tyr Thr Glu Ser Asn Leu His Gln His Leu Ala Ser Ala Gly
    370                 375                 380                 
His Met Arg Asn Glu Gln Ala Ser Val Glu Glu Leu Pro Glu Gly Gly
385                 390                 395                 400 
Ala Thr Phe Lys Cys Val Lys Cys Thr Glu Pro Phe Asp Ser Glu Gln
                405                 410                 415     
Asn Leu Phe Leu His Ile Lys Gly Gln His Glu Glu Leu Leu Arg Glu
            420                 425                 430         
Val Asn Lys Tyr Ile Val Glu Asp Thr Glu Gln Ile Asn Arg Glu Arg
        435                 440                 445             
Glu Glu Asn Gln Gly Asn Val Cys Lys Tyr Cys Gly Lys Met Cys Arg
    450                 455                 460                 
Ser Ser Asn Ser Met Ala Phe Leu Ala His Ile Arg Thr His Thr Gly
465                 470                 475                 480 
Ser Lys Pro Phe Lys Cys Lys Ile Cys His Phe Ala Thr Ala Gln Leu
                485                 490                 495     
Gly Asp Ala Arg Asn His Val Lys Arg His Leu Gly Met Arg Glu Tyr
            500                 505                 510         
Lys Cys His Val Cys Gly Val Ala Phe Val Met Lys Lys His Leu Asn
        515                 520                 525             
Thr His Leu Leu Gly Lys His Gly Val Gly Thr Pro Lys Glu Arg Lys
    530                 535                 540                 
Phe Thr Cys His Leu Cys Asp Arg Ser Phe Thr Glu Lys Trp Ala Leu
545                 550                 555                 560 
Asn Asn His Met Lys Leu His Thr Gly Glu Lys Pro Phe Lys Cys Thr
                565                 570                 575     
Trp Pro Thr Cys His Tyr Ser Phe Leu Thr Ala Ser Ala Met Lys Asp
            580                 585                 590         
His Tyr Arg Thr His Thr Gly Glu Lys Ser Phe Leu Cys Asp Leu Cys
        595                 600                 605             
Gly Phe Ala Gly Gly Thr Arg His Ala Leu Thr Lys His Arg Arg Gln
    610                 615                 620                 
His Thr Gly Glu Lys Pro Phe Lys Cys Asp Glu Cys Asn Phe Ala Ser
625                 630                 635                 640 
Thr Thr Gln Ser His Leu Thr Arg His Lys Arg Val His Thr Gly Glu
                645                 650                 655     
Lys Pro Tyr Arg Cys Pro Trp Cys Asp Tyr Arg Ser Asn Cys Ala Glu
            660                 665                 670         
Asn Ile Arg Lys His Ile Leu His Thr Gly Lys His Glu Gly Val Lys
        675                 680                 685             
Met Tyr Asn Cys Pro Lys Cys Asp Tyr Gly Thr Asn Val Pro Val Glu
    690                 695                 700                 
Phe Arg Asn His Leu Lys Glu Gln His Pro Asp Ile Glu Asn Pro Asp
705                 710                 715                 720 
Leu Ala Tyr Leu His Ala Gly Ile Val Ser Lys Ser Tyr Glu Cys Arg
                725                 730                 735     
Leu Lys Gly Gln Gly Ala Thr Phe Val Glu Thr Asp Ser Pro Phe Thr
            740                 745                 750         
Ala Ala Ala Leu Ala Glu Glu Pro Leu Val Lys Glu Lys Pro Leu Arg
        755                 760                 765             
Ser Ser Arg Arg Pro Ala Pro Pro Pro Glu Gln Val Gln Gln Val Ile
    770                 775                 780                 
Ile Phe Gln Gly Tyr Asp Gly Glu Phe Ala Leu Asp Pro Ser Val Glu
785                 790                 795                 800 
Glu Thr Ala Ala Ala Thr Leu Gln Thr Leu Ala Met Ala Gly Gln Val
                805                 810                 815     
Ala Arg Val Val His Ile Thr Glu Asp Gly Gln Val Ile Ala Thr Ser
            820                 825                 830         
Gln Ser Gly Ala His Val Gly Ser Val Val Pro Gly Pro Ile Leu Pro
        835                 840                 845             
Glu Gln Leu Ala Asp Gly Ala Thr Gln Val Val Val Val Gly Gly Ser
    850                 855                 860                 
Met Glu Gly His Gly Met Asp Glu Ser Leu Ser Pro Gly Gly Ala Val
865                 870                 875                 880 
Ile Gln Gln Val Thr Lys Gln Glu Ile Leu Asn Leu Ser Glu Ala Gly
                885                 890                 895     
Val Ala Pro Pro Glu Ala Ser Ser Ala Leu Asp Ala Leu Leu Cys Ala
            900                 905                 910         
Val Thr Glu Leu Gly Glu Val Glu Gly Arg Ala Gly Leu Glu Glu Gln
        915                 920                 925             
Gly Arg Pro Gly Ala Lys Asp Val Leu Ile Gln Leu Pro Gly Gln Glu
    930                 935                 940                 
Val Ser His Val Ala Ala Asp Pro Glu Ala Pro Glu Ile Gln Met Phe
945                 950                 955                 960 
Pro Gln Ala Gln Glu Ser Pro Ala Ala Val Glu Val Leu Thr Gln Val
                965                 970                 975     
Val His Pro Ser Ala Ala Met Ala Ser Gln Glu Arg Ala Gln Val Ala
            980                 985                 990         
Phe Lys Lys Met Val Gln Gly Val Leu Gln Phe Ala Val Cys Asp Thr
        995                 1000                1005            
Ala Ala Ala Gly Gln Leu Val Lys Asp Gly Val Thr Gln Val Val Val
    1010                1015                1020                
Ser Glu Glu Gly Ala Val His Met Val Ala Gly Glu Gly Ala Gln Ile
1025                1030                1035                1040
Ile Met Gln Glu Ala Gln Gly Glu His Met Asp Leu Val Glu Ser Asp
                1045                1050                1055    
Gly Glu Ile Ser Gln Ile Ile Val Thr Glu Glu Leu Val Gln Ala Met
            1060                1065                1070        
Val Gln Glu Ser Ser Gly Gly Phe Ser Glu Gly Thr Thr His Tyr Ile
        1075                1080                1085            
Leu Thr Glu Leu Pro Pro Gly Val Gln Asp Glu Pro Gly Leu Tyr Ser
    1090                1095                1100                
His Thr Val Leu Glu Thr Ala Asp Ser Gln Glu Leu Leu Gln Ala Gly
1105                1110                1115                1120
Ala Thr Leu Gly Thr Glu Ala Gly Ala Pro Ser Arg Ala Glu Gln Leu
                1125                1130                1135    
Ala Ser Val Val Ile Tyr Thr Gln Glu Gly Ser Ser Ala Ala Ala Ala
            1140                1145                1150        
Ile Gln Ser Gln Arg Glu Ser Ser Glu Leu Gln Glu Ala
        1155                1160                1165


<210> 1393
<211> 573
<212> PRT
<213> Homo sapiens

<400> 1393
Ser Trp Arg Thr Met Gly Ser Thr Leu Gly Cys His Arg Ser Ile Pro
 1               5                  10                  15      
Arg Asp Pro Ser Asp Leu Ser His Ser Arg Lys Phe Ser Ala Ala Cys
            20                  25                  30          
Asn Phe Ser Asn Ile Leu Val Asn Gln Glu Arg Leu Asn Ile Asn Thr
        35                  40                  45              
Ala Thr Glu Glu Glu Leu Met Thr Leu Pro Gly Val Thr Arg Ala Val
    50                  55                  60                  
Ala Arg Ser Ile Val Glu Tyr Arg Glu Tyr Ile Gly Gly Phe Lys Lys
65                  70                  75                  80  
Val Glu Asp Leu Ala Leu Val Ser Gly Val Gly Ala Thr Lys Leu Glu
                85                  90                  95      
Gln Val Lys Phe Glu Ile Cys Val Ser Ser Lys Gly Ser Ser Ala Gln
            100                 105                 110         
His Ser Pro Ser Ser Leu Arg Arg Asp Leu Leu Ala Glu Gln Gln Pro
        115                 120                 125             
His His Leu Ala Thr Ala Val Pro Leu Thr Pro Arg Val Asn Ile Asn
    130                 135                 140                 
Thr Ala Thr Pro Ala Gln Leu Met Ser Val Arg Gly Leu Ser Glu Lys
145                 150                 155                 160 
Met Ala Leu Ser Ile Val Asp Phe Arg Arg Glu His Gly Pro Phe Arg
                165                 170                 175     
Ser Val Glu Asp Leu Val Arg Met Asp Gly Ile Asn Ala Ala Phe Leu
            180                 185                 190         
Asp Arg Ile Arg His Gln Val Phe Ala Glu Arg Ser Arg Pro Pro Ser
        195                 200                 205             
Thr His Thr Asn Gly Gly Leu Thr Phe Thr Ala Lys Pro His Pro Ser
    210                 215                 220                 
Pro Thr Ser Leu Ser Leu Gln Ser Glu Asp Leu Asp Leu Pro Pro Gly
225                 230                 235                 240 
Gly Pro Thr Gln Ile Ile Ser Thr Arg Pro Ser Val Glu Ala Phe Gly
                245                 250                 255     
Gly Thr Arg Asp Gly Arg Pro Val Leu Arg Leu Ala Thr Trp Asn Leu
            260                 265                 270         
Gln Gly Cys Ser Val Glu Lys Ala Asn Asn Pro Gly Val Arg Glu Val
        275                 280                 285             
Val Cys Met Thr Leu Leu Glu Asn Ser Ile Lys Leu Leu Ala Val Gln
    290                 295                 300                 
Glu Leu Leu Asp Arg Glu Ala Leu Glu Lys Phe Cys Thr Glu Leu Asn
305                 310                 315                 320 
Gln Pro Thr Leu Pro Asn Ile Arg Lys Trp Lys Gly Pro Arg Gly Cys
                325                 330                 335     
Trp Lys Ala Val Val Ala Glu Lys Pro Ser Asn Gln Leu Gln Lys Gly
            340                 345                 350         
Ala Gly Tyr Ala Gly Phe Leu Trp Asp Ala Ala Ala Gly Met Glu Leu
        355                 360                 365             
Arg Asp Ala Gly Ser Gln Glu Ser Ser Pro Ser Asn Gly His Gly Lys
    370                 375                 380                 
Leu Ala Gly Pro Ser Pro Tyr Leu Gly Arg Phe Lys Val Gly Ser His
385                 390                 395                 400 
Asp Leu Thr Leu Val Asn Leu His Leu Ala Ala Leu Thr Leu Leu Gly
                405                 410                 415     
Ser Glu Asn Pro Ser Lys Asn His Ser Asp Gly His Arg Leu Ala Ser
            420                 425                 430         
Phe Ala Gln Thr Leu Gln Glu Thr Leu Lys Gly Glu Lys Asp Val Ile
        435                 440                 445             
Ile Leu Gly Asp Phe Gly Gln Gly Pro Asp Ser Asn Asp Tyr Asp Ile
    450                 455                 460                 
Leu Arg Lys Glu Lys Phe His His Leu Ile Pro Ala His Thr Phe Thr
465                 470                 475                 480 
Asn Ile Ser Thr Lys Asn Pro Gln Gly Ser Lys Ser Leu Asp Asn Ile
                485                 490                 495     
Trp Ile Ser Lys Ser Leu Lys Lys Val Phe Thr Gly His Trp Ala Val
            500                 505                 510         
Val Arg Glu Gly Leu Thr Asn Pro Trp Ile Pro Asp Asn Trp Ser Trp
        515                 520                 525             
Gly Gly Val Ala Ser Glu His Cys Pro Val Leu Ala Glu Phe Tyr Thr
    530                 535                 540                 
Glu Lys Asp Trp Ser Lys Lys Asp Ala Pro Arg Asn Gly Ser Gly Val
545                 550                 555                 560 
Ala Leu Glu Arg Ser Glu Ala Asn Ile Lys His Glu Arg
                565                 570             


<210> 1394
<211> 896
<212> PRT
<213> Homo sapiens

<400> 1394
Asp Val Ser Leu Tyr Lys Glu Gly Asn Ser Phe Gly Phe Val Leu Arg
 1               5                  10                  15      
Gly Gly Ala His Glu Asp Gly His Lys Ser Arg Pro Leu Val Leu Thr
            20                  25                  30          
Tyr Val Arg Pro Gly Gly Pro Ala Asp Arg Glu Gly Ser Leu Lys Val
        35                  40                  45              
Gly Asp Arg Leu Leu Ser Val Asp Gly Ile Pro Leu His Gly Ala Ser
    50                  55                  60                  
His Ala Thr Ala Leu Ala Thr Leu Arg Gln Cys Ser His Glu Ala Leu
65                  70                  75                  80  
Phe Gln Val Glu Tyr Asp Val Ala Thr Pro Asp Thr Val Ala Asn Ala
                85                  90                  95      
Ser Gly Pro Leu Met Val Glu Ile Val Lys Thr Pro Gly Ser Ala Leu
            100                 105                 110         
Gly Ile Ser Leu Thr Thr Thr Ser Leu Arg Asn Lys Ser Val Ile Thr
        115                 120                 125             
Ile Asp Arg Ile Lys Pro Ala Ser Val Val Asp Arg Ser Gly Ala Leu
    130                 135                 140                 
His Pro Gly Asp His Ile Leu Ser Ile Asp Gly Thr Ser Met Glu His
145                 150                 155                 160 
Cys Ser Leu Leu Glu Ala Thr Lys Leu Leu Ala Ser Ile Ser Glu Lys
                165                 170                 175     
Val Arg Leu Glu Ile Leu Pro Val Pro Gln Ser Gln Arg Pro Leu Arg
            180                 185                 190         
Pro Ser Glu Ala Val Lys Val Gln Arg Ser Glu Gln Leu His Arg Trp
        195                 200                 205             
Asp Pro Cys Val Pro Ser Cys His Ser Pro Arg Pro Gly His Cys Arg
    210                 215                 220                 
Met Pro Thr Trp Ala Thr Pro Ala Gly Gln Asp Gln Ser Arg Ser Leu
225                 230                 235                 240 
Ser Ser Thr Pro Phe Ser Ser Pro Thr Leu Asn His Ala Phe Ser Cys
                245                 250                 255     
Asn Asn Pro Ser Thr Leu Pro Arg Gly Ser Gln Pro Met Ser Pro Arg
            260                 265                 270         
Thr Thr Met Gly Arg Arg Arg Gln Arg Arg Arg Glu His Lys Ser Ser
        275                 280                 285             
Leu Ser Leu Ala Ser Ser Thr Val Gly Pro Gly Gly Gln Ile Val His
    290                 295                 300                 
Thr Glu Thr Thr Glu Val Val Leu Cys Gly Asp Pro Leu Ser Gly Phe
305                 310                 315                 320 
Gly Leu Gln Leu Gln Gly Gly Ile Phe Ala Thr Glu Thr Leu Ser Ser
                325                 330                 335     
Pro Pro Leu Val Cys Phe Ile Glu Pro Asp Ser Pro Ala Glu Arg Cys
            340                 345                 350         
Gly Leu Leu Gln Val Gly Asp Arg Val Leu Ser Ile Asn Gly Ile Ala
        355                 360                 365             
Thr Glu Asp Gly Thr Met Glu Glu Ala Asn Gln Leu Leu Arg Asp Ala
    370                 375                 380                 
Ala Leu Ala His Lys Val Val Leu Glu Val Glu Phe Asp Val Ala Glu
385                 390                 395                 400 
Ser Val Ile Pro Ser Ser Gly Thr Phe His Val Lys Leu Pro Lys Lys
                405                 410                 415     
Arg Ser Val Glu Leu Gly Ile Thr Ile Ser Ser Ala Ser Arg Lys Arg
            420                 425                 430         
Gly Glu Pro Leu Ile Ile Ser Asp Ile Lys Lys Gly Ser Val Ala His
        435                 440                 445             
Arg Thr Gly Thr Leu Glu Pro Gly Asp Lys Leu Leu Ala Ile Asp Asn
    450                 455                 460                 
Ile Arg Leu Asp Asn Cys Pro Met Glu Asp Ala Val Gln Ile Leu Arg
465                 470                 475                 480 
Gln Cys Glu Asp Leu Val Lys Leu Lys Ile Arg Lys Asp Glu Asp Asn
                485                 490                 495     
Ser Asp Glu Leu Glu Thr Thr Gly Ala Val Ser Tyr Thr Val Glu Leu
            500                 505                 510         
Lys Arg Tyr Gly Gly Pro Leu Gly Ile Thr Ile Ser Gly Thr Glu Glu
        515                 520                 525             
Pro Phe Asp Pro Ile Val Ile Ser Gly Leu Thr Lys Arg Gly Leu Ala
    530                 535                 540                 
Glu Arg Thr Gly Ala Ile His Val Gly Asp Arg Ile Leu Ala Ile Asn
545                 550                 555                 560 
Asn Val Ser Leu Lys Gly Arg Pro Leu Ser Glu Ala Ile His Leu Leu
                565                 570                 575     
Gln Val Ala Gly Glu Thr Val Thr Leu Lys Ile Lys Lys Gln Leu Asp
            580                 585                 590         
Arg Pro Leu Leu Pro Arg Lys Ser Gly Ser Leu Ser Glu Thr Ser Asp
        595                 600                 605             
Ala Asp Glu Asp Pro Ala Asp Ala Leu Lys Gly Gly Leu Pro Ala Ala
    610                 615                 620                 
Arg Phe Ser Pro Ala Val Pro Ser Val Asp Ser Ala Val Glu Ser Trp
625                 630                 635                 640 
Asp Ser Ser Ala Thr Glu Gly Gly Phe Gly Gly Pro Gly Ser Tyr Thr
                645                 650                 655     
Pro Gln Ala Ala Ala Arg Gly Thr Thr Pro Gln Glu Arg Arg Pro Gly
            660                 665                 670         
Trp Leu Arg Gly Ser Pro Pro Pro Thr Glu Pro Arg Arg Thr Ser Tyr
        675                 680                 685             
Thr Pro Thr Pro Ala Asp Glu Ser Phe Pro Glu Glu Glu Glu Gly Asp
    690                 695                 700                 
Asp Trp Glu Pro Pro Thr Ser Pro Ala Pro Gly Pro Ala Arg Glu Glu
705                 710                 715                 720 
Gly Phe Trp Arg Met Phe Gly Glu Ala Leu Glu Asp Leu Glu Ser Cys
                725                 730                 735     
Gly Gln Ser Glu Leu Leu Arg Glu Leu Glu Ala Ser Ile Met Thr Gly
            740                 745                 750         
Thr Val Gln Arg Val Ala Leu Glu Gly Arg Pro Gly His Arg Pro Trp
        755                 760                 765             
Gln Arg Gly Arg Glu Val Arg Ala Ser Pro Ala Glu Met Glu Glu Leu
    770                 775                 780                 
Leu Leu Pro Thr Pro Leu Glu Met His Lys Val Thr Leu His Lys Asp
785                 790                 795                 800 
Pro Met Arg His Asp Phe Gly Phe Ser Val Ser Asp Gly Leu Leu Glu
                805                 810                 815     
Lys Gly Val Tyr Val His Thr Val Arg Pro Asp Gly Pro Ala His Arg
            820                 825                 830         
Gly Gly Leu Gln Pro Phe Asp Arg Val Leu Gln Val Asn His Val Arg
        835                 840                 845             
Thr Arg Asp Phe Asp Cys Cys Leu Ala Val Pro Leu Leu Ala Glu Ala
    850                 855                 860                 
Gly Asp Val Leu Glu Leu Ile Ile Ser Arg Lys Pro His Thr Ala His
865                 870                 875                 880 
Ser Ser Arg Ala Pro Arg Ser Pro Gly Pro Ser Ser Pro Arg Met Leu
                885                 890                 895     


<210> 1395
<211> 1554
<212> PRT
<213> Homo sapiens

<400> 1395
Asn Asn Leu Ser Ser Ser Ser Ile Ser Phe Thr Leu Ile Trp Asn Ile
 1               5                  10                  15      
Ser Leu Cys Leu Leu Leu Asn Tyr Asp Asp Met Ser Val Ala Ile Arg
            20                  25                  30          
Lys Arg Ser Trp Glu Glu His Val Thr His Trp Met Gly Gln Pro Phe
        35                  40                  45              
Asn Ser Asp Asp Arg Asn Thr Ala Cys His His Gly Leu Val Ala Asp
    50                  55                  60                  
Ser Leu Gln Ala Ser Met Glu Lys Asp Ala Thr Leu Asn Val Asp Arg
65                  70                  75                  80  
Lys Glu Lys Cys Val Ser Leu Pro Asp Cys Cys His Gly Ser Glu Leu
                85                  90                  95      
Arg Asp Phe Pro Gly Arg Pro Met Gly His Leu Ser Lys Asp Val Asp
            100                 105                 110         
Glu Asn Asp Ser His Glu Gly Glu Asp Gln Phe Leu Ser Leu Glu Ala
        115                 120                 125             
Ser Thr Glu Thr Leu Val His Val Ser Asp Glu Asp Asn Asn Ala Asp
    130                 135                 140                 
Leu Cys Leu Thr Asp Asp Lys Gln Val Leu Asn Thr Gln Gly Gln Lys
145                 150                 155                 160 
Thr Ser Gly Gln His Met Ile Gln Gly Ala Gly Ser Leu Glu Lys Ala
                165                 170                 175     
Leu Pro Ile Ile Gln Ser Asn Gln Val Ser Ser Asn Ser Trp Gly Ile
            180                 185                 190         
Ala Gly Glu Thr Glu Leu Ala Leu Val Lys Glu Ser Gly Glu Arg Lys
        195                 200                 205             
Val Thr Asp Ser Ile Ser Lys Ser Leu Glu Leu Cys Asn Glu Ile Ser
    210                 215                 220                 
Leu Ser Glu Ile Lys Asp Ala Pro Lys Val Asn Ala Val Asp Thr Leu
225                 230                 235                 240 
Asn Val Lys Asp Ile Ala Pro Glu Lys Gln Leu Leu Asn Ser Ala Val
                245                 250                 255     
Ile Ala Gln Gln Arg Arg Lys Pro Asp Pro Pro Lys Asp Glu Asn Glu
            260                 265                 270         
Arg Ser Thr Cys Asn Val Val His Asp Glu Phe Leu Asp Ile Pro Cys
        275                 280                 285             
Thr Asn Arg Gly Leu Pro Leu Leu Lys Thr Asp Phe Gly Ser Cys Leu
    290                 295                 300                 
Leu Gln Pro Pro Ser Cys Pro Asn Gly Met Ser Ala Glu Asn Gly Leu
305                 310                 315                 320 
Glu Lys Ser Gly Phe Ser Gln His Gln Asn Lys Ser Pro Pro Lys Val
                325                 330                 335     
Lys Ala Glu Asp Gly Met Gln Cys Leu Gln Leu Lys Glu Thr Leu Ala
            340                 345                 350         
Thr Gln Glu Pro Thr Asp Asn Gln Val Arg Leu Arg Lys Arg Lys Glu
        355                 360                 365             
Ile Arg Glu Asp Arg Asp Arg Ala Arg Leu Asp Ser Met Val Leu Leu
    370                 375                 380                 
Ile Met Lys Leu Asp Gln Leu Asp Gln Asp Ile Glu Asn Ala Leu Ser
385                 390                 395                 400 
Thr Ser Ser Ser Pro Ser Gly Thr Pro Thr Asn Leu Arg Arg His Val
                405                 410                 415     
Pro Asp Leu Glu Ser Gly Ser Glu Ser Gly Ala Asp Thr Ile Ser Val
            420                 425                 430         
Asn Gln Thr Arg Val Asn Leu Ser Ser Asp Thr Glu Ser Thr Asp Leu
        435                 440                 445             
Pro Ser Ser Thr Pro Val Ala Asn Ser Gly Thr Lys Pro Lys Thr Thr
    450                 455                 460                 
Ala Ile Gln Gly Ile Ser Glu Lys Glu Lys Ala Glu Ile Glu Ala Lys
465                 470                 475                 480 
Glu Ala Cys Asp Trp Leu Arg Ala Thr Gly Phe Pro Gln Tyr Ala Gln
                485                 490                 495     
Leu Tyr Glu Asp Phe Leu Phe Pro Ile Asp Ile Ser Leu Val Lys Arg
            500                 505                 510         
Glu His Asp Phe Leu Asp Arg Asp Ala Ile Glu Ala Leu Cys Arg Arg
        515                 520                 525             
Leu Asn Thr Leu Asn Lys Cys Ala Val Met Lys Leu Glu Ile Ser Pro
    530                 535                 540                 
His Arg Lys Arg Ser Asp Asp Ser Asp Glu Asp Glu Pro Cys Ala Ile
545                 550                 555                 560 
Ser Gly Lys Trp Thr Phe Gln Arg Asp Ser Lys Arg Trp Ser Arg Leu
                565                 570                 575     
Glu Glu Phe Asp Val Phe Ser Pro Lys Gln Asp Leu Val Pro Gly Ser
            580                 585                 590         
Pro Asp Asp Ser Leu Pro Lys Asp Gly Pro Ser Pro Gly Gly Thr Leu
        595                 600                 605             
Met Asp Leu Ser Glu Arg Gln Glu Val Ser Ser Val Arg Ser Leu Ser
    610                 615                 620                 
Ser Thr Gly Ser Leu Pro Ser His Ala Pro Pro Ser Glu Asp Ala Ala
625                 630                 635                 640 
Thr Pro Arg Thr Asn Ser Val Ile Ser Val Cys Ser Ser Ser Asn Leu
                645                 650                 655     
Ala Gly Asn Asp Asp Ser Phe Gly Ser Leu Pro Ser Pro Lys Glu Leu
            660                 665                 670         
Ser Ser Phe Ser Phe Ser Met Lys Gly His Glu Lys Thr Ala Lys Ser
        675                 680                 685             
Lys Thr Arg Ser Leu Leu Lys Arg Met Glu Ser Leu Lys Leu Lys Ser
    690                 695                 700                 
Ser His His Ser Lys His Lys Ala Pro Ser Lys Leu Gly Leu Ile Ile
705                 710                 715                 720 
Ser Gly Pro Ile Leu Gln Glu Gly Met Asp Glu Glu Lys Leu Lys Gln
                725                 730                 735     
Leu Asn Cys Val Glu Ile Ser Ala Leu Asn Gly Asn Arg Ile Asn Val
            740                 745                 750         
Pro Met Val Arg Lys Arg Ser Val Ser Asn Ser Thr Gln Thr Ser Ser
        755                 760                 765             
Ser Ser Ser Gln Ser Glu Thr Ser Ser Ala Val Ser Thr Pro Ser Pro
    770                 775                 780                 
Val Thr Arg Thr Arg Ser Leu Ser Ala Cys Asn Lys Arg Val Gly Met
785                 790                 795                 800 
Tyr Leu Glu Gly Phe Asp Pro Phe Asn Gln Ser Thr Phe Asn Asn Val
                805                 810                 815     
Met Glu Gln Asn Phe Lys Asn Arg Glu Ser Tyr Pro Glu Asp Thr Val
            820                 825                 830         
Phe Tyr Ile Pro Glu Asp His Lys Pro Gly Thr Phe Pro Lys Ala Leu
        835                 840                 845             
Thr Asn Gly Ser Phe Ser Pro Ser Gly Asn Asn Gly Ser Val Asn Trp
    850                 855                 860                 
Arg Thr Gly Ser Phe His Gly Pro Gly His Ile Ser Leu Arg Arg Glu
865                 870                 875                 880 
Asn Ser Ser Asp Ser Pro Lys Glu Leu Lys Arg Arg Asn Ser Ser Ser
                885                 890                 895     
Ser Met Ser Ser Arg Leu Ser Ile Tyr Asp Asn Val Pro Gly Ser Ile
            900                 905                 910         
Leu Tyr Ser Ser Ser Gly Asp Leu Ala Asp Leu Glu Asn Glu Asp Ile
        915                 920                 925             
Phe Pro Glu Leu Asp Asp Ile Leu Tyr His Val Lys Gly Met Gln Arg
    930                 935                 940                 
Ile Val Asn Gln Trp Ser Glu Lys Phe Ser Asp Glu Gly Asp Ser Asp
945                 950                 955                 960 
Ser Ala Leu Asp Ser Val Ser Pro Cys Pro Ser Ser Pro Lys Gln Ile
                965                 970                 975     
His Leu Asp Val Asp Asn Asp Arg Thr Thr Pro Ser Asp Leu Asp Ser
            980                 985                 990         
Thr Gly Asn Ser Leu Asn Glu Pro Glu Glu Pro Ser Glu Ile Pro Glu
        995                 1000                1005            
Arg Arg Asp Ser Gly Val Gly Ala Ser Leu Thr Arg Ser Asn Arg His
    1010                1015                1020                
Arg Leu Arg Trp His Ser Phe Gln Ser Ser His Arg Pro Ser Leu Asn
1025                1030                1035                1040
Ser Val Ser Leu Gln Ile Asn Cys Gln Ser Val Ala Gln Met Asn Leu
                1045                1050                1055    
Leu Gln Lys Tyr Ser Leu Leu Lys Leu Thr Ala Leu Leu Glu Lys Tyr
            1060                1065                1070        
Thr Pro Ser Asn Lys His Gly Phe Ser Trp Ala Val Pro Lys Phe Met
        1075                1080                1085            
Lys Arg Ile Lys Val Pro Asp Tyr Lys Asp Arg Ser Val Phe Gly Val
    1090                1095                1100                
Pro Leu Thr Val Asn Val Gln Arg Thr Gly Gln Pro Leu Pro Gln Ser
1105                1110                1115                1120
Ile Gln Gln Ala Met Arg Tyr Leu Arg Asn His Cys Leu Asp Gln Val
                1125                1130                1135    
Gly Leu Phe Arg Lys Ser Gly Val Lys Ser Arg Ile Gln Ala Leu Arg
            1140                1145                1150        
Gln Met Asn Glu Gly Ala Ile Asp Cys Val Asn Tyr Glu Gly Gln Ser
        1155                1160                1165            
Ala Tyr Asp Val Ala Asp Met Leu Lys Gln Tyr Phe Arg Asp Leu Pro
    1170                1175                1180                
Glu Pro Leu Met Thr Asn Lys Leu Ser Glu Thr Phe Leu Gln Ile Tyr
1185                1190                1195                1200
Gln Tyr Val Pro Lys Asp Gln Arg Leu Gln Ala Ile Lys Ala Ala Ile
                1205                1210                1215    
Met Leu Leu Pro Asp Glu Asn Arg Glu Val Leu Gln Thr Leu Leu Tyr
            1220                1225                1230        
Phe Leu Ser Asp Val Thr Ala Ala Val Lys Glu Asn Gln Met Thr Pro
        1235                1240                1245            
Thr Asn Leu Ala Val Cys Leu Ala Pro Ser Leu Phe His Leu Asn Thr
    1250                1255                1260                
Leu Lys Arg Glu Asn Ser Ser Pro Arg Val Met Gln Arg Lys Gln Ser
1265                1270                1275                1280
Leu Gly Lys Pro Asp Gln Lys Asp Leu Asn Glu Asn Leu Ala Ala Thr
                1285                1290                1295    
Gln Gly Leu Ala His Met Ile Ala Glu Cys Lys Lys Leu Phe Gln Val
            1300                1305                1310        
Pro Glu Glu Met Ser Arg Cys Arg Asn Ser Tyr Thr Glu Gln Glu Leu
        1315                1320                1325            
Lys Pro Leu Thr Leu Glu Ala Leu Gly His Leu Gly Asn Asp Asp Ser
    1330                1335                1340                
Ala Asp Tyr Gln His Phe Leu Gln Asp Cys Val Asp Gly Leu Phe Lys
1345                1350                1355                1360
Glu Val Lys Glu Lys Phe Lys Gly Trp Val Ser Tyr Ser Thr Ser Glu
                1365                1370                1375    
Gln Ala Glu Leu Ser Tyr Lys Lys Val Ser Glu Gly Pro Pro Leu Arg
            1380                1385                1390        
Leu Trp Arg Ser Val Ile Glu Val Pro Ala Val Pro Glu Glu Ile Leu
        1395                1400                1405            
Lys Arg Leu Leu Lys Glu Gln His Leu Trp Asp Val Asp Leu Leu Asp
    1410                1415                1420                
Ser Lys Val Ile Glu Ile Leu Asp Ser Gln Thr Glu Ile Tyr Gln Tyr
1425                1430                1435                1440
Val Gln Asn Ser Met Ala Pro His Pro Ala Arg Asp Tyr Val Val Leu
                1445                1450                1455    
Arg Thr Trp Arg Thr Asn Leu Pro Lys Gly Ala Cys Ala Leu Leu Leu
            1460                1465                1470        
Thr Ser Val Asp His Asp Arg Ala Pro Val Val Gly Val Arg Val Asn
        1475                1480                1485            
Val Leu Leu Ser Arg Tyr Leu Ile Glu Pro Cys Gly Pro Gly Lys Ser
    1490                1495                1500                
Lys Leu Thr Tyr Met Cys Arg Val Asp Leu Arg Gly His Met Pro Glu
1505                1510                1515                1520
Trp Tyr Thr Lys Ser Phe Gly His Leu Cys Ala Ala Glu Val Val Lys
                1525                1530                1535    
Ile Arg Asp Ser Phe Ser Asn Gln Asn Thr Glu Thr Lys Asp Thr Lys
            1540                1545                1550        
Ser Arg
        


<210> 1396
<211> 1042
<212> PRT
<213> Homo sapiens

<400> 1396
Lys Lys His Gly Ser Lys Cys Leu Val His Cys Lys Met Gly Val Ser
 1               5                  10                  15      
Arg Ser Ala Ser Thr Val Ile Ala Tyr Ala Met Lys Glu Tyr Gly Trp
            20                  25                  30          
Asn Leu Asp Arg Ala Tyr Asp Tyr Val Lys Glu Arg Arg Thr Val Thr
        35                  40                  45              
Lys Pro Asn Pro Ser Phe Met Arg Gln Leu Glu Glu Tyr Gln Gly Ile
    50                  55                  60                  
Leu Leu Ala Ser Lys Gln Arg His Asn Lys Leu Trp Arg Ser His Ser
65                  70                  75                  80  
Asp Ser Asp Leu Ser Asp His His Glu Pro Ile Cys Lys Pro Gly Leu
                85                  90                  95      
Glu Leu Asn Lys Lys Asp Ile Thr Thr Ser Ala Asp Gln Ile Ala Glu
            100                 105                 110         
Val Lys Thr Met Glu Ser His Pro Pro Ile Pro Pro Val Phe Val Glu
        115                 120                 125             
His Met Val Pro Gln Asp Ala Asn Gln Lys Gly Leu Cys Thr Lys Glu
    130                 135                 140                 
Arg Met Ile Cys Leu Glu Phe Thr Ser Arg Glu Phe His Ala Gly Gln
145                 150                 155                 160 
Ile Glu Asp Glu Leu Asn Leu Asn Asp Ile Asn Gly Cys Ser Ser Gly
                165                 170                 175     
Cys Cys Leu Asn Glu Ser Lys Phe Pro Leu Asp Asn Cys His Ala Ser
            180                 185                 190         
Lys Ala Leu Ile Gln Pro Gly His Val Pro Glu Met Ala Asn Lys Phe
        195                 200                 205             
Pro Asp Leu Thr Val Glu Asp Leu Glu Thr Asp Ala Leu Lys Ala Asp
    210                 215                 220                 
Met Asn Val His Leu Leu Pro Met Glu Glu Leu Thr Ser Pro Leu Lys
225                 230                 235                 240 
Asp Pro Pro Met Ser Pro Asp Pro Glu Ser Pro Ser Pro Gln Pro Ser
                245                 250                 255     
Cys Gln Thr Glu Ile Ser Asp Phe Ser Thr Asp Arg Ile Asp Phe Phe
            260                 265                 270         
Ser Ala Leu Glu Lys Phe Val Glu Leu Ser Gln Glu Thr Arg Ser Arg
        275                 280                 285             
Ser Phe Ser His Ser Arg Met Glu Glu Leu Gly Gly Gly Arg Asn Glu
    290                 295                 300                 
Ser Cys Arg Leu Ser Val Val Glu Val Ala Pro Ser Lys Val Thr Ala
305                 310                 315                 320 
Asp Asp Gln Arg Ser Ser Ser Leu Ser Asn Thr Pro His Ala Ser Glu
                325                 330                 335     
Glu Ser Ser Met Asp Glu Glu Gln Ser Lys Ala Ile Ser Glu Leu Val
            340                 345                 350         
Ser Pro Asp Ile Phe Met Gln Ser His Ser Glu Asn Ala Ile Ser Val
        355                 360                 365             
Lys Glu Ile Val Thr Glu Ile Glu Ser Ile Ser Gln Gly Val Gly Gln
    370                 375                 380                 
Ile Gln Leu Lys Gly Asp Ile Leu Pro Asn Pro Cys His Thr Pro Lys
385                 390                 395                 400 
Lys Asn Ser Ile His Glu Leu Leu Leu Glu Arg Ala Gln Thr Pro Glu
                405                 410                 415     
Asn Lys Pro Gly His Met Glu Gln Asp Glu Asp Ser Cys Thr Ala Gln
            420                 425                 430         
Pro Glu Leu Ala Lys Asp Ser Gly Met Cys Asn Pro Glu Gly Cys Leu
        435                 440                 445             
Thr Thr His Ser Ser Ile Ala Asp Leu Glu Glu Gly Glu Pro Ala Glu
    450                 455                 460                 
Gly Glu Gln Glu Leu Gln Gly Ser Gly Met His Pro Gly Ala Lys Trp
465                 470                 475                 480 
Tyr Pro Gly Ser Val Arg Arg Ala Thr Leu Glu Phe Glu Glu Arg Leu
                485                 490                 495     
Arg Gln Glu Gln Glu His His Gly Ala Ala Pro Thr Cys Thr Ser Leu
            500                 505                 510         
Ser Thr Arg Lys Asn Ser Lys Asn Asp Ser Ser Val Ala Asp Leu Ala
        515                 520                 525             
Pro Lys Gly Lys Ser Asp Glu Ala Pro Pro Glu His Ser Phe Val Leu
    530                 535                 540                 
Lys Glu Pro Glu Met Ser Lys Gly Lys Gly Lys Tyr Ser Gly Ser Glu
545                 550                 555                 560 
Ala Gly Ser Leu Ser His Ser Glu Gln Asn Ala Thr Val Pro Ala Pro
                565                 570                 575     
Arg Val Leu Glu Phe Asp His Leu Pro Asp Pro Gln Glu Gly Pro Gly
            580                 585                 590         
Ser Asp Thr Gly Thr Gln Gln Glu Gly Val Leu Lys Asp Leu Arg Thr
        595                 600                 605             
Val Ile Pro Tyr Gln Glu Ser Glu Thr Gln Ala Val Pro Leu Pro Leu
    610                 615                 620                 
Pro Lys Arg Val Glu Ile Ile Glu Tyr Thr His Ile Val Thr Ser Pro
625                 630                 635                 640 
Asn His Thr Gly Pro Gly Ser Glu Ile Ala Thr Ser Glu Lys Ser Gly
                645                 650                 655     
Glu Gln Gly Leu Arg Lys Val Asn Met Glu Lys Ser Val Thr Val Leu
            660                 665                 670         
Cys Thr Leu Asp Glu Asn Leu Asn Arg Thr Leu Asp Pro Asn Gln Val
        675                 680                 685             
Ser Leu His Pro Gln Val Leu Pro Leu Pro His Ser Ser Ser Pro Glu
    690                 695                 700                 
His Asn Arg Pro Thr Asp His Pro Thr Ser Ile Leu Ser Ser Pro Glu
705                 710                 715                 720 
Asp Arg Gly Ser Ser Leu Ser Thr Ala Leu Glu Thr Ala Ala Pro Phe
                725                 730                 735     
Val Ser His Thr Thr His Leu Leu Ser Ala Ser Leu Asp Tyr Leu His
            740                 745                 750         
Pro Gln Thr Met Val His Leu Glu Gly Phe Thr Glu Gln Ser Ser Thr
        755                 760                 765             
Thr Asp Glu Pro Ser Ala Glu Gln Val Ser Trp Glu Glu Ser Gln Glu
    770                 775                 780                 
Ser Pro Leu Ser Ser Gly Ser Glu Val Pro Tyr Lys Asp Ser Gln Leu
785                 790                 795                 800 
Ser Ser Ala Asp Leu Ser Leu Ile Ser Lys Leu Gly Asp Asn Thr Gly
                805                 810                 815     
Glu Leu Gln Glu Lys Met Asp Pro Leu Pro Val Ala Cys Arg Leu Pro
            820                 825                 830         
His Ser Ser Ser Ser Glu Asn Ile Lys Ser Leu Ser His Ser Pro Gly
        835                 840                 845             
Val Val Lys Glu Arg Ala Lys Glu Ile Glu Ser Arg Val Val Phe Gln
    850                 855                 860                 
Ala Gly Leu Thr Lys Pro Ser Gln Met Arg Arg Ser Ala Ser Leu Ala
865                 870                 875                 880 
Lys Leu Gly Tyr Leu Asp Leu Cys Lys Asp Cys Leu Pro Glu Arg Glu
                885                 890                 895     
Pro Ala Ser Cys Glu Ser Pro His Leu Lys Leu Leu Gln Pro Phe Leu
            900                 905                 910         
Arg Thr Asp Ser Gly Met His Ala Met Glu Asp Gln Glu Ser Leu Glu
        915                 920                 925             
Asn Pro Gly Ala Pro His Asn Pro Glu Pro Thr Lys Ser Phe Val Glu
    930                 935                 940                 
Gln Leu Thr Thr Thr Glu Cys Ile Val Gln Ser Lys Pro Val Glu Arg
945                 950                 955                 960 
Pro Leu Val Gln Tyr Ala Lys Glu Phe Gly Ser Ser Gln Gln Tyr Leu
                965                 970                 975     
Leu Pro Arg Ala Gly Leu Glu Leu Thr Ser Ser Glu Gly Gly Leu Pro
            980                 985                 990         
Val Leu Gln Thr Gln Gly Leu Gln Cys Ala Cys Pro Ala Pro Gly Leu
        995                 1000                1005            
Ala Val Ala Pro Arg Gln Gln His Gly Arg Thr His Pro Leu Arg Arg
    1010                1015                1020                
Leu Lys Lys Ala Asn Asp Lys Lys Arg Thr Thr Asn Pro Phe Tyr Asn
1025                1030                1035                1040
Thr Met
        


<210> 1397
<211> 1098
<212> PRT
<213> Homo sapiens

<400> 1397
Tyr Thr Pro Val Met Ala Ala Arg Gln Ala Val Gly Ser Gly Ala Gln
 1               5                  10                  15      
Glu Thr Cys Gly Leu Asp Arg Ile Leu Glu Ala Leu Lys Leu Leu Leu
            20                  25                  30          
Ser Pro Gly Gly Ser Gly Ser Ser Ser Leu Gln Val Thr Lys His Asp
        35                  40                  45              
Val Leu Leu Ala Thr Leu Lys Ser Asn Leu Ser Ala Leu Glu Asp Lys
    50                  55                  60                  
Phe Leu Lys Asp Pro Gln Trp Lys Asn Leu Lys Leu Leu Arg Asp Glu
65                  70                  75                  80  
Ile Ala Asp Lys Ala Glu Trp Pro Gln Asn Ser Val Asp Val Thr Trp
                85                  90                  95      
Ser Phe Thr Ser Gln Thr Leu Leu Leu Leu Leu Cys Leu Lys Glu Thr
            100                 105                 110         
Met Ile Arg Leu Ala Ala Asn Phe Asn Pro Gly Lys Pro Asn Pro Arg
        115                 120                 125             
Thr Pro Glu Val Ala Pro Ala Leu Ser Pro Asp Ala Leu Ser Ile Ser
    130                 135                 140                 
Gln Gln Lys Thr Val Gln Phe Val Leu Gln Phe Val Val Thr Leu Gly
145                 150                 155                 160 
Ile Cys Pro Tyr Leu Met Pro Gly Val Gly Val Pro Leu Arg Tyr Arg
                165                 170                 175     
Thr Glu Phe Gly Ala Val Val Gln Asp Val Val Cys Phe Asp Ala Ala
            180                 185                 190         
Pro Asp Ala Thr Arg Arg Leu Tyr Thr Ser Cys Lys Ala Leu Leu Asn
        195                 200                 205             
Val Ala Gln His Thr Ser Leu Gly Ser Leu Ile Phe Cys His His Phe
    210                 215                 220                 
Gly Asp Ile Ala Ala Gly Leu Cys Gln Leu Gly Phe Cys Pro Thr Lys
225                 230                 235                 240 
Arg Lys Leu Leu Thr Pro Ala Glu Glu Val Leu Thr Glu Glu Glu Arg
                245                 250                 255     
Thr Leu Ser Arg Gly Ala Leu Arg Asp Met Leu Asp Gln Val Tyr Gln
            260                 265                 270         
Pro Leu Ala Val Arg Glu Leu Leu Ile Leu Gln Gly Gly Pro Pro Gln
        275                 280                 285             
Ser Cys Thr Asp Val Lys Thr Gln Met Arg Cys Arg Ala Pro Ala Trp
    290                 295                 300                 
Leu Arg Arg Leu Cys Gly Gln Leu Leu Ser Glu Arg Leu Met Arg Pro
305                 310                 315                 320 
Asn Gly Val Gln Ala Val Val Arg Gly Ile Leu Glu Gly Ala Gly Ala
                325                 330                 335     
Gly Ala Ala Gly Gly Ser Asp Ala Glu Val Thr Ala Ala Asp Trp Lys
            340                 345                 350         
Lys Cys Asp Leu Ile Ala Lys Ile Leu Ala Ser Cys Pro Gln Gln Ser
        355                 360                 365             
Leu Ser Pro Glu Asn Tyr Tyr Arg Asp Ile Cys Pro Gln Val Leu Asp
    370                 375                 380                 
Leu Phe His Phe Gln Asp Lys Leu Thr Ala Arg Gln Phe Gln Arg Val
385                 390                 395                 400 
Ala Thr Thr Thr Phe Ile Thr Leu Ser Arg Glu Arg Pro His Leu Ala
                405                 410                 415     
Ala Lys Tyr Leu Leu Gln Pro Val Leu Ala Pro Leu His Arg Cys Leu
            420                 425                 430         
Asn Thr Ala Glu Leu Ser Glu Ser Asp Met Val Pro Gly Thr Ile Leu
        435                 440                 445             
Val Thr Glu Glu Glu Leu Ser Arg Cys Ile Glu Asp Val Phe Lys Val
    450                 455                 460                 
Tyr Val Val Gly Asn Glu Pro Leu Thr Val Leu Met Asp Ser Leu Leu
465                 470                 475                 480 
Pro Val Leu Gly Val Leu Phe Leu Leu Tyr Cys Phe Thr Lys Gln Ser
                485                 490                 495     
Val Ser His Ile Arg Ser Leu Cys Gln Glu Ile Leu Leu Trp Ile Leu
            500                 505                 510         
Gly Lys Leu Glu Arg Lys Lys Ala Ile Ala Ser Leu Lys Gly Phe Ala
        515                 520                 525             
Gly Leu Asp Lys Ala Val Pro Ser Leu His Ser Leu Cys Gln Phe Arg
    530                 535                 540                 
Val Ala Thr Gln Gly Gly Ile Met Ile Thr Ile Lys Glu Ala Ile Ser
545                 550                 555                 560 
Asp Glu Asp Glu Asp Glu Ala Leu Tyr Gln Lys Val Ser Ser Glu Gln
                565                 570                 575     
Gly Arg Val Glu His Leu Gly Asp Leu Leu Ser His Cys Gln Glu Cys
            580                 585                 590         
Gly Leu Ala Gly Asp Phe Phe Ile Phe Cys Leu Lys Glu Leu Thr His
        595                 600                 605             
Val Ala Ser Glu Asn Glu Thr Glu Leu Lys Thr Glu Pro Phe Ser Ser
    610                 615                 620                 
Lys Ser Leu Leu Glu Leu Glu Gln His Gln Thr Leu Leu Val Glu Gly
625                 630                 635                 640 
Gln Glu Arg Lys Leu Leu Val Leu Gln Leu Met Ala Val Leu Cys Glu
                645                 650                 655     
Arg Met Ser Glu Gln Ile Phe Thr Asn Val Thr Gln Val Val Asp Phe
            660                 665                 670         
Val Ala Ala Thr Leu Gln Arg Ala Cys Ala Ser Leu Ala His Gln Ala
        675                 680                 685             
Glu Ser Thr Val Glu Ser Gln Thr Leu Ser Met Ser Met Gly Leu Val
    690                 695                 700                 
Ala Val Met Leu Gly Gly Ala Val Gln Leu Lys Ser Ser Asp Phe Ala
705                 710                 715                 720 
Val Leu Lys Gln Leu Leu Pro Leu Leu Glu Lys Val Ser Asn Thr Tyr
                725                 730                 735     
Pro Asp Pro Val Ile Gln Glu Leu Ala Val Asp Leu Arg Ile Thr Ile
            740                 745                 750         
Ser Thr His Gly Ala Phe Ala Thr Glu Ala Val Ser Met Ala Ala Gln
        755                 760                 765             
Ser Thr Leu Asn Arg Lys Asp Leu Glu Gly Lys Ile Glu Glu Gln Gln
    770                 775                 780                 
Gln Thr Ser His Glu Arg Pro Thr Asp Val Ala His Ser His Leu Glu
785                 790                 795                 800 
Gln Gln Gln Ser His Glu Thr Ala Pro Gln Thr Gly Leu Gln Ser Asn
                805                 810                 815     
Ala Pro Ile Ile Pro Gln Gly Val Asn Glu Pro Ser Thr Thr Thr Ser
            820                 825                 830         
Gln Lys Ser Gly Ser Val Thr Thr Glu Gln Leu Gln Glu Val Leu Leu
        835                 840                 845             
Ser Ala Tyr Asp Pro Gln Ile Pro Thr Arg Ala Ala Ala Leu Arg Thr
    850                 855                 860                 
Leu Ser His Trp Ile Glu Gln Arg Glu Ala Lys Ala Leu Glu Met Gln
865                 870                 875                 880 
Glu Lys Leu Leu Lys Ile Phe Leu Glu Asn Leu Glu His Glu Asp Thr
                885                 890                 895     
Phe Val Tyr Leu Ser Ala Ile Gln Gly Val Ala Leu Leu Ser Asp Val
            900                 905                 910         
Tyr Pro Glu Lys Ile Leu Pro Asp Leu Leu Ala Gln Tyr Asp Ser Ser
        915                 920                 925             
Lys Asp Lys His Thr Pro Glu Thr Arg Met Lys Val Gly Glu Val Leu
    930                 935                 940                 
Met Arg Ile Val Arg Ala Leu Gly Asp Met Val Ser Lys Tyr Arg Glu
945                 950                 955                 960 
Pro Leu Ile His Thr Phe Leu Arg Gly Val Arg Asp Pro Asp Gly Ala
                965                 970                 975     
His Arg Ala Ser Ser Leu Ala Asn Leu Gly Glu Leu Cys Gln Arg Leu
            980                 985                 990         
Asp Phe Leu Leu Gly Ser Val Val His Glu Val Thr Ala Cys Leu Ile
        995                 1000                1005            
Ala Val Ala Lys Thr Asp Gly Glu Val Gln Val Arg Arg Ala Ala Ile
    1010                1015                1020                
His Val Val Val Leu Leu Leu Arg Gly Leu Ser Gln Lys Ala Thr Glu
1025                1030                1035                1040
Val Leu Ser Ala Val Leu Lys Asp Leu Tyr His Leu Leu Lys His Val
                1045                1050                1055    
Val Cys Leu Glu Pro Asp Asp Val Ala Lys Leu His Ala Gln Leu Ala
            1060                1065                1070        
Leu Glu Glu Leu Asp Asp Ile Met Lys Asn Phe Leu Phe Pro Pro Gln
        1075                1080                1085            
Lys Leu Glu Lys Lys Ile Met Val Leu Pro
    1090                1095            


<210> 1398
<211> 360
<212> PRT
<213> Homo sapiens

<400> 1398
Arg Trp His Leu Gly Lys Thr Ile Glu Lys Leu Gln Lys Glu Met Ala
 1               5                  10                  15      
Asp Ile Val Glu Ala Ser Arg Thr Ser Thr Leu Glu Leu Gln Asn Gln
            20                  25                  30          
Leu Asp Glu Tyr Lys Glu Lys Asn Arg Arg Glu Leu Ala Glu Met Gln
        35                  40                  45              
Arg Gln Leu Lys Glu Lys Thr Leu Glu Ala Glu Lys Ser Arg Leu Thr
    50                  55                  60                  
Ala Met Lys Met Gln Asp Glu Met Arg Leu Met Glu Glu Glu Leu Arg
65                  70                  75                  80  
Asp Tyr Gln Arg Ala Gln Asp Glu Ala Leu Thr Lys Arg Gln Leu Leu
                85                  90                  95      
Glu Gln Thr Leu Lys Asp Leu Glu Tyr Glu Leu Glu Ala Lys Ser His
            100                 105                 110         
Leu Lys Asp Asp Arg Ser Arg Leu Val Lys Gln Met Glu Asp Lys Val
        115                 120                 125             
Ser Gln Leu Glu Met Glu Leu Glu Glu Glu Arg Asn Asn Ser Asp Leu
    130                 135                 140                 
Leu Ser Glu Arg Ile Ser Arg Ser Arg Glu Gln Met Glu Gln Val Arg
145                 150                 155                 160 
Asn Glu Leu Leu Gln Glu Arg Ala Ala Arg Gln Asp Leu Glu Cys Asp
                165                 170                 175     
Lys Ile Ser Leu Glu Arg Gln Asn Lys Asp Leu Lys Ser Arg Ile Ile
            180                 185                 190         
His Leu Glu Gly Ser Tyr Arg Ser Ser Lys Glu Gly Leu Val Val Gln
        195                 200                 205             
Met Glu Ala Arg Ile Ala Glu Leu Glu Asp Arg Leu Glu Ser Glu Glu
    210                 215                 220                 
Arg Asp Arg Ala Asn Leu Gln Leu Ser Asn Arg Arg Leu Glu Arg Lys
225                 230                 235                 240 
Val Lys Glu Leu Val Met Gln Val Asp Asp Glu His Leu Ser Leu Thr
                245                 250                 255     
Asp Gln Lys Asp Gln Leu Ser Leu Arg Leu Lys Ala Met Lys Arg Gln
            260                 265                 270         
Val Glu Glu Ala Glu Glu Glu Ile Asp Arg Leu Glu Ser Ser Lys Lys
        275                 280                 285             
Lys Leu Gln Arg Glu Leu Glu Glu Gln Met Asp Met Asn Glu His Leu
    290                 295                 300                 
Gln Gly Gln Leu Asn Ser Met Lys Lys Asp Leu Arg Leu Lys Lys Leu
305                 310                 315                 320 
Pro Ser Lys Val Leu Asp Asp Met Asp Asp Asp Asp Asp Leu Ser Thr
                325                 330                 335     
Asp Gly Gly Ser Leu Tyr Glu Ala Pro Val Ser Tyr Thr Phe Ser Lys
            340                 345                 350         
Asp Ser Thr Val Ala Ser Gln Ile
        355                 360 


<210> 1399
<211> 1001
<212> PRT
<213> Homo sapiens

<400> 1399
Gln Arg Lys Leu Glu Gln His Lys Asp Leu Leu Gln Asn Thr Asp Ala
 1               5                  10                  15      
His Lys Arg Ala Phe His Glu Ile Tyr Arg Thr Arg Ser Val Asn Gly
            20                  25                  30          
Ile Pro Val Pro Pro Asp Gln Leu Glu Asp Met Ala Glu Arg Phe His
        35                  40                  45              
Phe Val Ser Ser Thr Ser Glu Leu His Leu Met Lys Met Glu Phe Leu
    50                  55                  60                  
Glu Leu Lys Tyr Arg Leu Leu Ser Leu Leu Val Leu Ala Glu Ser Lys
65                  70                  75                  80  
Leu Lys Ser Trp Ile Ile Lys Tyr Gly Arg Arg Glu Ser Val Glu Gln
                85                  90                  95      
Leu Leu Gln Asn Tyr Val Ser Phe Ile Glu Asn Ser Lys Phe Phe Glu
            100                 105                 110         
Gln Tyr Glu Val Thr Tyr Gln Ile Leu Lys Gln Thr Ala Glu Met Tyr
        115                 120                 125             
Val Lys Ala Asp Gly Ser Val Glu Glu Ala Glu Asn Val Met Lys Phe
    130                 135                 140                 
Met Asn Glu Thr Thr Ala Gln Trp Arg Asn Leu Ser Val Glu Val Arg
145                 150                 155                 160 
Ser Val Arg Ser Met Leu Glu Glu Val Ile Ser Asn Trp Asp Arg Tyr
                165                 170                 175     
Gly Asn Thr Val Ala Ser Leu Gln Ala Trp Leu Glu Asp Ala Glu Lys
            180                 185                 190         
Met Leu Asn Gln Ser Glu Asn Ala Lys Lys Asp Phe Phe Arg Asn Leu
        195                 200                 205             
Pro His Trp Ile Gln Gln His Thr Ala Met Asn Asp Ala Gly Asn Phe
    210                 215                 220                 
Leu Ile Glu Thr Cys Asp Glu Met Val Ser Arg Asp Leu Lys Gln Gln
225                 230                 235                 240 
Leu Leu Leu Leu Asn Gly Arg Trp Arg Glu Leu Phe Met Glu Val Lys
                245                 250                 255     
Gln Tyr Ala Gln Ala Asp Glu Met Asp Arg Met Lys Lys Glu Tyr Thr
            260                 265                 270         
Asp Cys Val Val Thr Leu Ser Ala Phe Ala Thr Glu Ala His Lys Lys
        275                 280                 285             
Leu Ser Glu Pro Leu Glu Val Ser Phe Met Asn Val Lys Leu Leu Ile
    290                 295                 300                 
Gln Asp Leu Glu Asp Ile Glu Gln Arg Val Pro Val Met Asp Ala Gln
305                 310                 315                 320 
Tyr Lys Ile Ile Thr Lys Thr Ala His Leu Ile Thr Lys Glu Ser Pro
                325                 330                 335     
Gln Glu Glu Gly Lys Glu Met Phe Ala Thr Met Ser Lys Leu Lys Glu
            340                 345                 350         
Gln Leu Thr Lys Val Lys Glu Cys Tyr Ser Pro Leu Leu Tyr Glu Ser
        355                 360                 365             
Gln Gln Leu Leu Ile Pro Leu Glu Glu Leu Glu Lys Gln Met Thr Ser
    370                 375                 380                 
Phe Tyr Asp Ser Leu Gly Lys Ile Asn Glu Ile Ile Thr Val Leu Glu
385                 390                 395                 400 
Arg Glu Ala Gln Ser Ser Ala Leu Phe Lys Gln Lys His Gln Glu Leu
                405                 410                 415     
Leu Ala Cys Gln Glu Asn Cys Lys Lys Thr Leu Thr Leu Ile Glu Lys
            420                 425                 430         
Gly Ser Gln Ser Val Gln Lys Phe Val Thr Leu Ser Asn Val Leu Lys
        435                 440                 445             
His Phe Asp Gln Thr Arg Leu Gln Arg Gln Ile Ala Asp Ile His Val
    450                 455                 460                 
Ala Phe Gln Ser Met Val Lys Lys Thr Gly Asp Trp Lys Lys His Val
465                 470                 475                 480 
Glu Thr Asn Ser Arg Leu Met Lys Lys Phe Glu Glu Ser Arg Ala Glu
                485                 490                 495     
Leu Glu Lys Val Leu Arg Ile Ala Gln Glu Gly Leu Glu Glu Lys Gly
            500                 505                 510         
Asp Pro Glu Glu Leu Leu Arg Arg His Thr Glu Phe Phe Ser Gln Leu
        515                 520                 525             
Asp Gln Arg Val Leu Asn Ala Phe Leu Lys Ala Cys Asp Glu Leu Thr
    530                 535                 540                 
Asp Ile Leu Pro Glu Gln Glu Gln Gln Gly Leu Gln Glu Ala Val Arg
545                 550                 555                 560 
Lys Leu His Lys Gln Trp Lys Asp Leu Gln Gly Glu Ala Pro Tyr His
                565                 570                 575     
Leu Leu His Leu Lys Ile Asp Val Glu Lys Asn Arg Phe Leu Ala Ser
            580                 585                 590         
Val Glu Glu Cys Arg Thr Glu Leu Asp Arg Glu Thr Lys Leu Met Pro
        595                 600                 605             
Gln Glu Gly Ser Glu Lys Ile Ile Lys Glu His Arg Val Phe Phe Ser
    610                 615                 620                 
Asp Lys Gly Pro His His Leu Cys Glu Lys Arg Leu Gln Leu Ile Glu
625                 630                 635                 640 
Glu Leu Cys Val Lys Leu Pro Val Arg Asp Pro Val Arg Asp Thr Pro
                645                 650                 655     
Gly Thr Cys His Val Thr Leu Lys Glu Leu Arg Ala Ala Ile Asp Ser
            660                 665                 670         
Thr Tyr Arg Lys Leu Met Glu Asp Pro Asp Lys Trp Lys Asp Tyr Thr
        675                 680                 685             
Ser Arg Phe Ser Glu Phe Ser Ser Trp Ile Ser Thr Asn Glu Thr Gln
    690                 695                 700                 
Leu Lys Gly Ile Lys Gly Glu Ala Ile Asp Thr Ala Asn His Gly Glu
705                 710                 715                 720 
Val Lys Arg Ala Val Glu Glu Ile Arg Asn Gly Val Thr Lys Arg Gly
                725                 730                 735     
Glu Thr Leu Ser Trp Leu Lys Ser Arg Leu Lys Val Leu Thr Glu Val
            740                 745                 750         
Ser Ser Glu Asn Glu Ala Gln Lys Gln Gly Asp Glu Leu Ala Lys Leu
        755                 760                 765             
Ser Ser Ser Phe Lys Ala Leu Val Thr Leu Leu Ser Glu Val Glu Lys
    770                 775                 780                 
Met Leu Ser Asn Phe Gly Asp Cys Val Gln Tyr Lys Glu Ile Val Lys
785                 790                 795                 800 
Asn Ser Leu Glu Glu Leu Ile Ser Gly Ser Lys Glu Val Gln Glu Gln
                805                 810                 815     
Ala Glu Lys Ile Leu Asp Thr Glu Asn Leu Phe Glu Ala Gln Gln Leu
            820                 825                 830         
Leu Leu His His Gln Gln Lys Thr Lys Arg Ile Ser Ala Lys Lys Arg
        835                 840                 845             
Asp Val Gln Gln Gln Ile Ala Gln Ala Gln Gln Gly Glu Gly Gly Leu
    850                 855                 860                 
Pro Asp Arg Gly His Glu Glu Leu Arg Lys Leu Glu Ser Thr Leu Asp
865                 870                 875                 880 
Gly Leu Glu Arg Ser Arg Glu Arg Gln Glu Arg Arg Ile Gln Val Thr
                885                 890                 895     
Leu Arg Lys Trp Glu Arg Phe Glu Thr Asn Lys Glu Thr Val Val Arg
            900                 905                 910         
Tyr Leu Phe Gln Thr Gly Ser Ser His Glu Arg Phe Leu Ser Phe Ser
        915                 920                 925             
Ser Leu Glu Ser Leu Ser Ser Glu Leu Glu Gln Thr Lys Glu Phe Ser
    930                 935                 940                 
Lys Arg Thr Glu Ser Ile Ala Val Gln Ala Glu Asn Leu Val Lys Glu
945                 950                 955                 960 
Ala Ser Glu Ile Pro Leu Gly Pro Gln Asn Lys Gln Leu Leu Gln Gln
                965                 970                 975     
Gln Ala Lys Ser Ile Lys Glu Gln Val Lys Lys Leu Glu Asp Thr Leu
            980                 985                 990         
Glu Glu Glu Tyr Val Ile Asp Lys Ser
        995                 1000    


<210> 1400
<211> 1460
<212> PRT
<213> Homo sapiens

<400> 1400
Asp Lys Pro Ser Gly Ser Pro Gly Gln Pro Pro Ser Pro Ala Pro Ser
 1               5                  10                  15      
Pro Val Pro Glu Pro Asp Ala Gln Ala Glu Asp Val Ala Pro Pro Pro
            20                  25                  30          
Thr Met Ala Glu Glu Glu Glu Gly Thr Thr Gly Glu Leu Arg Ser Ala
        35                  40                  45              
Glu Pro Ala Pro Ala Asp Ser Arg His Pro Leu Thr Tyr Arg Lys Thr
    50                  55                  60                  
Thr Asn Phe Ala Leu Asp Lys Phe Leu Asp Pro Ala Arg Pro Tyr Lys
65                  70                  75                  80  
Cys Thr Val Cys Lys Glu Ser Phe Thr Gln Lys Asn Ile Leu Leu Val
                85                  90                  95      
His Tyr Asn Ser Val Ser His Leu His Lys Met Lys Lys Ala Ala Ile
            100                 105                 110         
Asp Pro Ser Ala Pro Ala Arg Gly Glu Ala Gly Ala Pro Pro Thr Thr
        115                 120                 125             
Thr Ala Ala Thr Asp Lys Pro Phe Lys Cys Thr Val Cys Arg Val Ser
    130                 135                 140                 
Tyr Asn Gln Ser Ser Thr Leu Glu Ile His Met Arg Ser Val Leu His
145                 150                 155                 160 
Gln Thr Arg Ser Arg Gly Thr Lys Thr Asp Ser Lys Ile Glu Gly Pro
                165                 170                 175     
Glu Arg Ser Gln Glu Glu Pro Lys Glu Gly Glu Thr Glu Gly Glu Val
            180                 185                 190         
Gly Thr Glu Lys Lys Gly Pro Asp Thr Ser Gly Phe Ile Ser Gly Leu
        195                 200                 205             
Pro Phe Leu Ser Pro Pro Pro Pro Pro Leu Asp Leu His Arg Phe Pro
    210                 215                 220                 
Ala Pro Leu Phe Thr Pro Pro Val Leu Pro Pro Phe Pro Leu Val Pro
225                 230                 235                 240 
Glu Ser Leu Leu Lys Leu Gln Gln Gln Gln Leu Leu Leu Pro Phe Tyr
                245                 250                 255     
Leu His Asp Leu Lys Val Gly Pro Lys Leu Thr Leu Ala Gly Pro Ala
            260                 265                 270         
Pro Val Leu Ser Leu Pro Ala Ala Thr Pro Pro Pro Pro Pro Gln Pro
        275                 280                 285             
Pro Lys Ala Glu Leu Ala Glu Arg Glu Trp Glu Arg Pro Pro Met Ala
    290                 295                 300                 
Lys Glu Gly Asn Glu Ala Gly Pro Ser Ser Pro Pro Asp Pro Leu Pro
305                 310                 315                 320 
Asn Glu Ala Ala Arg Thr Ala Ala Lys Ala Leu Leu Glu Asn Phe Gly
                325                 330                 335     
Phe Glu Leu Val Ile Gln Tyr Asn Glu Gly Lys Gln Ala Val Pro Pro
            340                 345                 350         
Pro Pro Thr Pro Pro Pro Pro Glu Ala Leu Gly Gly Gly Asp Lys Leu
        355                 360                 365             
Ala Cys Gly Ala Cys Gly Lys Leu Phe Ser Asn Met Leu Ile Leu Lys
    370                 375                 380                 
Thr His Glu Glu His Val His Arg Arg Phe Leu Pro Phe Glu Ala Leu
385                 390                 395                 400 
Ser Arg Tyr Ala Ala Gln Phe Arg Lys Ser Tyr Asp Ser Leu Tyr Pro
                405                 410                 415     
Pro Leu Ala Glu Pro Pro Lys Pro Pro Asp Gly Ser Leu Asp Ser Pro
            420                 425                 430         
Val Pro His Leu Gly Pro Pro Phe Leu Val Pro Glu Pro Glu Ala Gly
        435                 440                 445             
Gly Thr Arg Ala Pro Glu Glu Arg Ser Arg Ala Gly Gly His Trp Pro
    450                 455                 460                 
Ile Glu Glu Glu Glu Ser Ser Arg Gly Asn Leu Pro Pro Leu Val Pro
465                 470                 475                 480 
Ala Gly Arg Arg Phe Ser Arg Thr Lys Phe Thr Glu Phe Gln Thr Gln
                485                 490                 495     
Ala Leu Gln Ser Phe Phe Glu Thr Ser Ala Tyr Pro Lys Asp Gly Glu
            500                 505                 510         
Val Glu Arg Leu Ala Ser Leu Leu Gly Leu Ala Ser Arg Val Val Val
        515                 520                 525             
Val Trp Phe Gln Asn Ala Arg Gln Lys Ala Arg Lys Asn Ala Cys Glu
    530                 535                 540                 
Gly Gly Ser Met Pro Thr Gly Gly Gly Thr Gly Gly Ala Ser Gly Cys
545                 550                 555                 560 
Arg Arg Cys His Ala Thr Phe Ser Cys Val Phe Glu Leu Val Arg His
                565                 570                 575     
Leu Lys Lys Cys Tyr Asp Asp Gln Thr Leu Glu Glu Glu Glu Glu Glu
            580                 585                 590         
Ala Glu Arg Gly Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Val Glu
        595                 600                 605             
Glu Glu Gln Gly Leu Glu Pro Pro Ala Gly Pro Glu Gly Pro Leu Pro
    610                 615                 620                 
Glu Pro Pro Asp Gly Glu Glu Leu Ser Gln Ala Glu Ala Thr Lys Ala
625                 630                 635                 640 
Gly Gly Lys Glu Pro Glu Glu Lys Ala Thr Pro Ser Pro Ser Pro Ala
                645                 650                 655     
His Thr Cys Asp Gln Cys Ala Ile Ser Phe Ser Ser Gln Asp Leu Leu
            660                 665                 670         
Thr Ser His Arg Arg Leu His Phe Leu Pro Ser Leu Gln Pro Ser Ala
        675                 680                 685             
Pro Pro Gln Leu Leu Asp Leu Pro Leu Leu Val Phe Gly Glu Arg Asn
    690                 695                 700                 
Pro Leu Val Ala Ala Thr Ser Pro Met Pro Gly Pro Pro Leu Lys Arg
705                 710                 715                 720 
Lys His Glu Asp Gly Ser Leu Ser Pro Thr Gly Ser Glu Ala Gly Gly
                725                 730                 735     
Gly Gly Glu Gly Glu Pro Pro Arg Asp Lys Arg Leu Arg Thr Thr Ile
            740                 745                 750         
Leu Pro Glu Gln Leu Glu Ile Leu Tyr Arg Trp Tyr Met Gln Asp Ser
        755                 760                 765             
Asn Pro Thr Arg Lys Met Leu Asp Cys Ile Ser Glu Glu Val Gly Leu
    770                 775                 780                 
Lys Lys Arg Val Val Gln Val Trp Phe Gln Asn Thr Arg Ala Arg Glu
785                 790                 795                 800 
Arg Lys Gly Gln Phe Arg Ser Thr Pro Gly Gly Val Pro Ser Pro Ala
                805                 810                 815     
Val Lys Pro Pro Ala Thr Ala Thr Pro Ala Ser Leu Pro Lys Phe Asn
            820                 825                 830         
Leu Leu Leu Gly Lys Val Asp Asp Gly Thr Gly Arg Glu Ala Pro Lys
        835                 840                 845             
Arg Glu Ala Pro Ala Phe Pro Tyr Pro Thr Ala Thr Leu Ala Ser Gly
    850                 855                 860                 
Pro Gln Pro Phe Leu Pro Pro Gly Lys Glu Ala Thr Thr Pro Thr Pro
865                 870                 875                 880 
Glu Pro Pro Leu Pro Leu Leu Pro Pro Pro Pro Pro Ser Glu Glu Glu
                885                 890                 895     
Gly Pro Glu Glu Pro Pro Lys Ala Ser Pro Glu Ser Glu Ala Cys Ser
            900                 905                 910         
Leu Ser Ala Gly Asp Leu Ser Asp Ser Ser Ala Ser Ser Leu Ala Glu
        915                 920                 925             
Pro Glu Ser Pro Gly Ala Gly Gly Thr Ser Gly Gly Pro Gly Gly Gly
    930                 935                 940                 
Thr Gly Val Pro Asp Gly Met Gly Gln Arg Arg Tyr Arg Thr Gln Met
945                 950                 955                 960 
Ser Ser Leu Gln Leu Lys Ile Met Lys Ala Cys Tyr Glu Ala Tyr Arg
                965                 970                 975     
Thr Pro Thr Met Gln Glu Cys Glu Val Leu Gly Glu Glu Ile Gly Leu
            980                 985                 990         
Pro Lys Arg Val Ile Gln Val Trp Phe Gln Asn Ala Arg Ala Lys Glu
        995                 1000                1005            
Lys Lys Ala Lys Leu Gln Gly Thr Ala Ala Gly Ser Thr Gly Gly Ser
    1010                1015                1020                
Ser Glu Gly Leu Leu Ala Ala Gln Arg Thr Asp Cys Pro Tyr Cys Asp
1025                1030                1035                1040
Val Lys Tyr Asp Phe Tyr Val Ser Cys Arg Gly His Leu Phe Ser Arg
                1045                1050                1055    
Gln His Leu Ala Lys Leu Lys Glu Ala Val Arg Ala Gln Leu Lys Ser
            1060                1065                1070        
Glu Ser Lys Cys Tyr Asp Leu Ala Pro Ala Pro Glu Ala Pro Pro Ala
        1075                1080                1085            
Leu Lys Ala Pro Pro Ala Thr Thr Pro Ala Ser Met Pro Leu Gly Ala
    1090                1095                1100                
Ala Pro Thr Leu Pro Arg Leu Ala Pro Val Leu Leu Ser Gly Pro Ala
1105                1110                1115                1120
Leu Ala Gln Pro Pro Leu Gly Asn Leu Ala Pro Phe Asn Ser Gly Pro
                1125                1130                1135    
Ala Ala Ser Ser Gly Leu Leu Gly Leu Ala Thr Ser Val Leu Pro Thr
            1140                1145                1150        
Thr Thr Val Val Gln Thr Ala Gly Pro Gly Arg Pro Leu Pro Gln Arg
        1155                1160                1165            
Pro Met Pro Asp Gln Thr Asn Thr Ser Thr Ala Gly Thr Thr Asp Pro
    1170                1175                1180                
Val Pro Gly Pro Pro Thr Glu Pro Leu Gly Asp Lys Val Ser Ser Glu
1185                1190                1195                1200
Arg Lys Pro Val Ala Gly Pro Thr Ser Ser Ser Asn Asp Ala Leu Lys
                1205                1210                1215    
Asn Leu Lys Ala Leu Lys Thr Thr Val Pro Ala Leu Leu Gly Gly Gln
            1220                1225                1230        
Phe Leu Pro Phe Pro Leu Pro Pro Ala Gly Gly Thr Ala Pro Pro Ala
        1235                1240                1245            
Val Phe Gly Pro Gln Leu Gln Gly Ala Tyr Phe Gln Gln Leu Tyr Gly
    1250                1255                1260                
Met Lys Lys Gly Leu Phe Pro Met Asn Pro Met Ile Pro Gln Thr Leu
1265                1270                1275                1280
Ile Gly Leu Leu Pro Asn Ala Leu Leu Gln Pro Pro Pro Gln Pro Pro
                1285                1290                1295    
Glu Pro Thr Ala Thr Ala Pro Pro Lys Pro Pro Glu Leu Pro Ala Pro
            1300                1305                1310        
Gly Glu Gly Glu Ala Gly Glu Val Asp Glu Leu Leu Thr Gly Ser Thr
        1315                1320                1325            
Gly Ile Ser Thr Val Asp Val Thr His Arg Tyr Leu Cys Arg Gln Cys
    1330                1335                1340                
Lys Met Ala Phe Asp Gly Glu Ala Pro Ala Thr Ala His Gln Arg Ser
1345                1350                1355                1360
Phe Cys Phe Phe Gly Arg Gly Ser Gly Gly Ser Met Pro Pro Pro Leu
                1365                1370                1375    
Arg Val Pro Ile Cys Thr Tyr His Cys Leu Ala Cys Glu Val Leu Leu
            1380                1385                1390        
Ser Gly Arg Glu Ala Leu Ala Ser His Leu Arg Ser Ser Ala His Arg
        1395                1400                1405            
Arg Lys Ala Ala Pro Pro Gln Gly Gly Pro Pro Ile Ser Ile Thr Asn
    1410                1415                1420                
Ala Ala Thr Ala Ala Ser Ala Ala Val Ala Phe Ala Lys Glu Glu Ala
1425                1430                1435                1440
Arg Leu Pro His Thr Asp Ser Asn Pro Lys Thr Thr Thr Thr Ser Thr
                1445                1450                1455    
Leu Leu Ala Leu
            1460


<210> 1401
<211> 608
<212> PRT
<213> Homo sapiens

<400> 1401
Ser Arg Leu Phe Ser Lys Ala Leu Lys Gly Asp His Arg Cys Gly Glu
 1               5                  10                  15      
Thr Glu Thr Pro Lys Ser Cys Ser Glu Val Ala Gly Cys Lys Ala Ala
            20                  25                  30          
Met Arg His Gln Gly Lys Ile Pro Glu Glu Leu Ser Leu Asp Asp Arg
        35                  40                  45              
Ala Arg Thr Gln Lys Lys Trp Gly Arg Gly Lys Trp Glu Pro Glu Pro
    50                  55                  60                  
Ser Ser Lys Pro Pro Arg Glu Ala Thr Leu Glu Glu Arg His Ala Arg
65                  70                  75                  80  
Gly Glu Lys His Leu Gly Val Glu Ile Glu Lys Thr Ser Gly Glu Ile
                85                  90                  95      
Ile Arg Cys Glu Lys Cys Lys Arg Glu Arg Glu Leu Gln Gln Ser Leu
            100                 105                 110         
Glu Arg Glu Arg Leu Ser Leu Gly Thr Ser Glu Leu Asp Met Gly Lys
        115                 120                 125             
Gly Pro Met Tyr Asp Val Glu Lys Leu Val Arg Thr Arg Ser Cys Arg
    130                 135                 140                 
Arg Ser Pro Glu Ala Asn Pro Ala Ser Gly Glu Glu Gly Trp Lys Gly
145                 150                 155                 160 
Asp Ser His Arg Ser Ser Pro Arg Asn Pro Thr Gln Glu Leu Arg Arg
                165                 170                 175     
Pro Ser Lys Ser Met Asp Lys Lys Glu Asp Arg Gly Pro Glu Asp Gln
            180                 185                 190         
Glu Ser His Ala Gln Gly Ala Ala Lys Ala Lys Lys Asp Leu Val Glu
        195                 200                 205             
Val Leu Pro Val Thr Glu Glu Gly Leu Arg Glu Val Lys Lys Asp Thr
    210                 215                 220                 
Arg Pro Met Ser Arg Ser Lys His Gly Gly Trp Leu Leu Arg Glu His
225                 230                 235                 240 
Gln Ala Gly Phe Glu Lys Leu Arg Arg Thr Arg Gly Glu Glu Lys Glu
                245                 250                 255     
Ala Glu Lys Glu Lys Lys Pro Cys Met Ser Gly Gly Arg Arg Met Thr
            260                 265                 270         
Leu Arg Asp Asp Gln Pro Ala Lys Leu Glu Lys Glu Pro Lys Thr Arg
        275                 280                 285             
Pro Glu Glu Asn Lys Pro Glu Arg Pro Ser Gly Arg Lys Pro Arg Pro
    290                 295                 300                 
Met Gly Ile Ile Ala Ala Asn Val Glu Lys His Tyr Glu Thr Gly Arg
305                 310                 315                 320 
Val Ile Gly Asp Gly Asn Phe Ala Val Val Lys Glu Cys Arg His Arg
                325                 330                 335     
Glu Thr Arg Gln Ala Tyr Ala Met Lys Ile Ile Asp Lys Ser Arg Leu
            340                 345                 350         
Lys Gly Lys Glu Asp Met Val Asp Ser Glu Ile Leu Ile Ile Gln Ser
        355                 360                 365             
Leu Ser His Pro Asn Ile Val Lys Leu His Glu Val Tyr Glu Thr Asp
    370                 375                 380                 
Met Glu Ile Tyr Leu Ile Leu Glu Tyr Val Gln Gly Gly Asp Leu Phe
385                 390                 395                 400 
Asp Ala Ile Ile Glu Ser Val Lys Phe Pro Glu Pro Asp Ala Ala Leu
                405                 410                 415     
Met Ile Met Asp Leu Cys Lys Ala Leu Val His Met His Asp Lys Ser
            420                 425                 430         
Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Val Gln Arg Asn
        435                 440                 445             
Glu Asp Lys Ser Thr Thr Leu Lys Leu Ala Asp Phe Gly Leu Ala Lys
    450                 455                 460                 
His Val Val Arg Pro Ile Phe Thr Val Cys Gly Thr Pro Thr Tyr Val
465                 470                 475                 480 
Ala Pro Glu Ile Leu Ser Glu Lys Gly Tyr Gly Leu Glu Val Asp Met
                485                 490                 495     
Trp Ala Ala Gly Val Ile Leu Tyr Ile Leu Leu Cys Gly Phe Pro Pro
            500                 505                 510         
Phe Arg Ser Pro Glu Arg Asp Gln Asp Glu Leu Phe Asn Ile Ile Gln
        515                 520                 525             
Leu Gly His Phe Glu Phe Leu Pro Pro Tyr Trp Asp Asn Ile Ser Asp
    530                 535                 540                 
Ala Ala Lys Asp Leu Val Ser Arg Leu Leu Val Val Asp Pro Lys Lys
545                 550                 555                 560 
Arg Tyr Thr Ala His Gln Val Leu Gln His Pro Trp Ile Glu Thr Ala
                565                 570                 575     
Gly Lys Thr Asn Thr Val Lys Arg Gln Lys Gln Val Ser Pro Ser Ser
            580                 585                 590         
Glu Gly His Phe Arg Ser Gln His Lys Arg Val Val Glu Gln Val Ser
        595                 600                 605             


<210> 1402
<211> 258
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 10, 258
<223> Xaa = Any Amino Acid

<400> 1402
Asp Tyr Leu Asn Gly Pro Phe Thr Val Xaa Val Lys Glu Ser Cys Asp
 1               5                  10                  15      
Gly Met Gly Asp Val Ser Glu Lys His Gly Ser Gly Pro Val Val Pro
            20                  25                  30          
Glu Lys Ala Val Arg Phe Ser Phe Thr Ile Met Lys Ile Thr Ile Ala
        35                  40                  45              
His Ser Ser Gln Asn Val Lys Val Phe Glu Glu Ala Lys Pro Asn Ser
    50                  55                  60                  
Glu Leu Cys Cys Lys Pro Leu Cys Leu Met Leu Ala Asp Glu Ser Asp
65                  70                  75                  80  
His Glu Thr Leu Thr Ala Ile Leu Ser Pro Leu Ile Ala Glu Arg Glu
                85                  90                  95      
Ala Met Lys Ser Ser Glu Leu Met Leu Glu Leu Gly Gly Ile Leu Arg
            100                 105                 110         
Thr Phe Lys Phe Ile Phe Arg Gly Thr Gly Tyr Asp Glu Lys Leu Val
        115                 120                 125             
Arg Glu Val Glu Gly Leu Glu Ala Ser Gly Ser Val Tyr Ile Cys Thr
    130                 135                 140                 
Leu Cys Asp Ala Thr Arg Leu Glu Ala Ser Gln Asn Leu Val Phe His
145                 150                 155                 160 
Ser Ile Thr Arg Ser His Ala Glu Asn Leu Glu Arg Tyr Glu Val Trp
                165                 170                 175     
Arg Ser Asn Pro Tyr His Glu Ser Val Glu Glu Leu Arg Asp Arg Val
            180                 185                 190         
Lys Gly Val Ser Ala Lys Pro Phe Ile Glu Thr Val Pro Ser Ile Asp
        195                 200                 205             
Ala Leu His Cys Asp Ile Gly Asn Ala Ala Glu Phe Tyr Lys Ile Phe
    210                 215                 220                 
Gln Leu Glu Ile Gly Glu Val Tyr Lys Asn Pro Asn Ala Ser Lys Glu
225                 230                 235                 240 
Glu Arg Lys Arg Trp Gln Ala Thr Leu Asp Lys His Leu Arg Lys Lys
                245                 250                 255     
Met Xaa
        


<210> 1403
<211> 290
<212> PRT
<213> Homo sapiens

<400> 1403
Met Ala Ala Leu Arg Val Leu Leu Ser Cys Ala Arg Gly Pro Leu Arg
 1               5                  10                  15      
Pro Pro Val Arg Cys Pro Ala Trp Arg Pro Phe Ala Ser Gly Ala Asn
            20                  25                  30          
Phe Glu Tyr Ile Ile Ala Glu Lys Arg Gly Lys Asn Asn Thr Val Gly
        35                  40                  45              
Leu Ile Gln Leu Asn Arg Pro Lys Ala Leu Asn Ala Leu Cys Asp Gly
    50                  55                  60                  
Leu Ile Asp Glu Leu Asn Gln Ala Leu Lys Ile Phe Glu Glu Asp Pro
65                  70                  75                  80  
Ala Val Gly Ala Ile Val Leu Thr Gly Gly Asp Lys Ala Phe Ala Ala
                85                  90                  95      
Gly Ala Asp Ile Lys Glu Met Gln Asn Leu Ser Phe Gln Asp Cys Tyr
            100                 105                 110         
Ser Ser Lys Phe Leu Lys His Trp Asp His Leu Thr Gln Val Lys Lys
        115                 120                 125             
Pro Val Ile Ala Ala Val Asn Gly Tyr Ala Phe Gly Gly Gly Cys Glu
    130                 135                 140                 
Leu Ala Met Met Cys Asp Ile Ile Tyr Ala Gly Glu Lys Ala Gln Phe
145                 150                 155                 160 
Ala Gln Pro Glu Ile Leu Ile Gly Thr Ile Pro Gly Ala Gly Gly Thr
                165                 170                 175     
Gln Arg Leu Thr Arg Ala Val Gly Lys Ser Leu Ala Met Glu Met Val
            180                 185                 190         
Leu Thr Gly Asp Arg Ile Ser Ala Gln Asp Ala Lys Gln Ala Gly Leu
        195                 200                 205             
Val Ser Lys Ile Cys Pro Val Glu Thr Leu Val Glu Glu Ala Ile Gln
    210                 215                 220                 
Cys Ala Glu Lys Ile Ala Ser Asn Ser Lys Ile Val Val Ala Met Ala
225                 230                 235                 240 
Lys Glu Ser Val Asn Ala Ala Phe Glu Met Thr Leu Thr Glu Gly Ser
                245                 250                 255     
Lys Leu Glu Lys Lys Leu Phe Tyr Ser Thr Phe Ala Thr Asp Asp Arg
            260                 265                 270         
Lys Glu Gly Met Thr Ala Phe Val Glu Lys Arg Lys Ala Asn Phe Lys
        275                 280                 285             
Asp Gln
    290 


<210> 1404
<211> 2382
<212> PRT
<213> Homo sapiens

<400> 1404
Met Ser Gly Gly Ala Ala Glu Lys Gln Ser Ser Thr Pro Gly Ser Leu
 1               5                  10                  15      
Phe Leu Ser Pro Pro Ala Pro Ala Pro Lys Asn Gly Ser Ser Ser Asp
            20                  25                  30          
Ser Ser Val Gly Glu Lys Leu Gly Ala Ala Ala Ala Asp Ala Val Thr
        35                  40                  45              
Gly Arg Thr Glu Glu Tyr Arg Arg Arg Arg His Thr Met Asp Lys Asp
    50                  55                  60                  
Ser Arg Gly Ala Ala Ala Thr Thr Thr Thr Thr Glu His Arg Phe Phe
65                  70                  75                  80  
Arg Arg Ser Val Ile Cys Asp Ser Asn Ala Thr Ala Leu Glu Leu Pro
                85                  90                  95      
Gly Leu Pro Leu Ser Leu Pro Gln Pro Ser Ile Pro Ala Ala Val Pro
            100                 105                 110         
Gln Ser Ala Pro Pro Glu Pro His Arg Glu Glu Thr Val Thr Ala Thr
        115                 120                 125             
Ala Thr Ser Gln Val Ala Gln Gln Pro Pro Ala Ala Ala Ala Pro Gly
    130                 135                 140                 
Glu Gln Ala Val Ala Gly Pro Ala Pro Ser Thr Val Pro Ser Ser Thr
145                 150                 155                 160 
Ser Lys Asp Arg Pro Val Ser Gln Pro Ser Leu Val Gly Ser Lys Glu
                165                 170                 175     
Glu Pro Pro Pro Ala Arg Ser Gly Ser Gly Gly Gly Ser Ala Lys Glu
            180                 185                 190         
Pro Gln Glu Glu Arg Ser Gln Gln Gln Asp Asp Ile Glu Glu Leu Glu
        195                 200                 205             
Thr Lys Ala Val Gly Met Ser Asn Asp Gly Arg Phe Leu Lys Phe Asp
    210                 215                 220                 
Ile Glu Ile Gly Arg Gly Ser Phe Lys Thr Val Tyr Lys Gly Leu Asp
225                 230                 235                 240 
Thr Glu Thr Thr Val Glu Val Ala Trp Cys Glu Leu Gln Asp Arg Lys
                245                 250                 255     
Leu Thr Lys Ser Glu Arg Gln Arg Phe Lys Glu Glu Ala Glu Met Leu
            260                 265                 270         
Lys Gly Leu Gln His Pro Asn Ile Val Arg Phe Tyr Asp Ser Trp Glu
        275                 280                 285             
Ser Thr Val Lys Gly Lys Lys Cys Ile Val Leu Val Thr Glu Leu Met
    290                 295                 300                 
Thr Ser Gly Thr Leu Lys Thr Tyr Leu Lys Arg Phe Lys Val Met Lys
305                 310                 315                 320 
Ile Lys Val Leu Arg Ser Trp Cys Arg Gln Ile Leu Lys Gly Leu Gln
                325                 330                 335     
Phe Leu His Thr Arg Thr Pro Pro Ile Ile His Arg Asp Leu Lys Cys
            340                 345                 350         
Asp Asn Ile Phe Ile Thr Gly Pro Thr Gly Ser Val Lys Ile Gly Asp
        355                 360                 365             
Leu Gly Leu Ala Thr Leu Lys Arg Ala Ser Phe Ala Lys Ser Val Ile
    370                 375                 380                 
Gly Thr Pro Glu Phe Met Ala Pro Glu Met Tyr Glu Glu Lys Tyr Asp
385                 390                 395                 400 
Glu Ser Val Asp Val Tyr Ala Phe Gly Met Cys Met Leu Glu Met Ala
                405                 410                 415     
Thr Ser Glu Tyr Pro Tyr Ser Glu Cys Gln Asn Ala Ala Gln Ile Tyr
            420                 425                 430         
Arg Arg Val Thr Ser Gly Val Lys Pro Ala Ser Phe Asp Lys Val Ala
        435                 440                 445             
Ile Pro Glu Val Lys Glu Ile Ile Glu Gly Cys Ile Arg Gln Asn Lys
    450                 455                 460                 
Asp Glu Arg Tyr Ser Ile Lys Asp Leu Leu Asn His Ala Phe Phe Gln
465                 470                 475                 480 
Glu Glu Thr Gly Val Arg Val Glu Leu Ala Glu Glu Asp Asp Gly Glu
                485                 490                 495     
Lys Ile Ala Ile Lys Leu Trp Leu Arg Ile Glu Asp Ile Lys Lys Leu
            500                 505                 510         
Lys Gly Lys Tyr Lys Asp Asn Glu Ala Ile Glu Phe Ser Phe Asp Leu
        515                 520                 525             
Glu Arg Asp Val Pro Glu Asp Val Ala Gln Glu Met Val Glu Ser Gly
    530                 535                 540                 
Tyr Val Cys Glu Gly Asp His Lys Thr Met Ala Lys Ala Ile Lys Asp
545                 550                 555                 560 
Arg Val Ser Leu Ile Lys Arg Lys Arg Glu Gln Arg Gln Leu Val Arg
                565                 570                 575     
Glu Glu Gln Glu Lys Lys Lys Gln Glu Glu Ser Ser Leu Lys Gln Gln
            580                 585                 590         
Val Glu Gln Ser Ser Ala Ser Gln Thr Gly Ile Lys Gln Leu Pro Ser
        595                 600                 605             
Ala Ser Thr Gly Ile Pro Thr Ala Ser Thr Thr Ser Ala Ser Val Ser
    610                 615                 620                 
Thr Gln Val Glu Pro Glu Glu Pro Glu Ala Asp Gln His Gln Gln Leu
625                 630                 635                 640 
Gln Tyr Gln Gln Pro Ser Ile Ser Val Leu Ser Asp Gly Thr Val Asp
                645                 650                 655     
Ser Gly Gln Gly Ser Ser Val Phe Thr Glu Ser Arg Val Ser Ser Gln
            660                 665                 670         
Gln Thr Val Ser Tyr Gly Ser Gln His Glu Gln Ala His Ser Thr Gly
        675                 680                 685             
Thr Val Pro Gly His Ile Pro Ser Thr Val Gln Ala Gln Ser Gln Pro
    690                 695                 700                 
His Gly Val Tyr Pro Pro Ser Ser Val Ala Gln Gly Gln Ser Gln Gly
705                 710                 715                 720 
Gln Pro Ser Ser Ser Ser Leu Thr Gly Val Ser Ser Ser Gln Pro Ile
                725                 730                 735     
Gln His Pro Gln Gln Gln Gln Gly Ile Gln Gln Thr Ala Pro Pro Gln
            740                 745                 750         
Gln Thr Val Gln Tyr Ser Leu Ser Gln Thr Ser Thr Ser Ser Glu Ala
        755                 760                 765             
Thr Thr Ala Gln Pro Val Ser Gln Pro Gln Ala Pro Gln Val Leu Pro
    770                 775                 780                 
Gln Val Ser Ala Gly Lys Gln Leu Pro Val Ser Gln Pro Val Pro Thr
785                 790                 795                 800 
Ile Gln Gly Glu Pro Gln Ile Pro Val Ala Thr Gln Pro Ser Val Val
                805                 810                 815     
Pro Val His Ser Gly Ala His Phe Leu Pro Val Gly Gln Pro Leu Pro
            820                 825                 830         
Thr Pro Leu Leu Pro Gln Tyr Pro Val Ser Gln Ile Pro Ile Ser Thr
        835                 840                 845             
Pro His Val Ser Thr Ala Gln Thr Gly Phe Ser Ser Leu Pro Ile Thr
    850                 855                 860                 
Met Ala Ala Gly Ile Thr Gln Pro Leu Leu Thr Leu Ala Ser Ser Ala
865                 870                 875                 880 
Thr Thr Ala Ala Ile Pro Gly Val Ser Thr Val Val Pro Ser Gln Leu
                885                 890                 895     
Pro Thr Leu Leu Gln Pro Val Thr Gln Leu Pro Ser Gln Val His Pro
            900                 905                 910         
Gln Leu Leu Gln Pro Ala Val Gln Ser Met Gly Ile Pro Ala Asn Leu
        915                 920                 925             
Gly Gln Ala Ala Glu Val Pro Leu Ser Ser Gly Asp Val Leu Tyr Gln
    930                 935                 940                 
Gly Phe Pro Pro Arg Leu Pro Pro Gln Tyr Pro Gly Asp Ser Asn Ile
945                 950                 955                 960 
Ala Pro Ser Ser Asn Val Ala Ser Val Cys Ile His Ser Thr Val Leu
                965                 970                 975     
Ser Pro Pro Met Pro Thr Glu Val Leu Ala Thr Pro Gly Tyr Phe Pro
            980                 985                 990         
Thr Val Val Gln Pro Tyr Val Glu Ser Asn Leu Leu Val Pro Met Gly
        995                 1000                1005            
Gly Val Gly Gly Gln Val Gln Val Ser Gln Pro Gly Gly Ser Leu Ala
    1010                1015                1020                
Gln Ala Pro Thr Thr Ser Ser Gln Gln Ala Val Leu Glu Ser Thr Gln
1025                1030                1035                1040
Gly Val Ser Gln Val Ala Pro Ala Glu Pro Val Ala Val Ala Gln Pro
                1045                1050                1055    
Gln Ala Thr Gln Pro Thr Thr Leu Ala Ser Ser Val Asp Ser Ala His
            1060                1065                1070        
Ser Asp Val Ala Ser Gly Met Ser Asp Gly Asn Glu Asn Val Pro Ser
        1075                1080                1085            
Ser Ser Gly Arg His Glu Gly Arg Thr Thr Lys Arg His Tyr Arg Lys
    1090                1095                1100                
Ser Val Arg Ser Arg Ser Arg His Glu Lys Thr Ser Arg Pro Lys Leu
1105                1110                1115                1120
Arg Ile Leu Asn Val Ser Asn Lys Gly Asp Arg Val Val Glu Cys Gln
                1125                1130                1135    
Leu Glu Thr His Asn Arg Lys Met Val Thr Phe Lys Phe Asp Leu Asp
            1140                1145                1150        
Gly Asp Asn Pro Glu Glu Ile Ala Thr Ile Met Val Asn Asn Asp Phe
        1155                1160                1165            
Ile Leu Ala Ile Glu Arg Glu Ser Phe Val Asp Gln Val Arg Glu Ile
    1170                1175                1180                
Ile Glu Lys Ala Asp Glu Met Leu Ser Glu Asp Val Ser Val Glu Pro
1185                1190                1195                1200
Glu Gly Asp Gln Gly Leu Glu Ser Leu Gln Gly Lys Asp Asp Tyr Gly
                1205                1210                1215    
Phe Ser Gly Ser Gln Lys Leu Glu Gly Glu Phe Lys Gln Pro Ile Pro
            1220                1225                1230        
Ala Ser Ser Met Pro Gln Gln Ile Gly Ile Pro Thr Ser Ser Leu Thr
        1235                1240                1245            
Gln Val Val His Ser Ala Gly Arg Arg Phe Ile Val Ser Pro Val Pro
    1250                1255                1260                
Glu Ser Arg Leu Arg Glu Ser Lys Val Phe Pro Ser Glu Ile Thr Asp
1265                1270                1275                1280
Thr Val Ala Ala Ser Thr Ala Gln Ser Pro Gly Met Asn Leu Ser His
                1285                1290                1295    
Ser Ala Ser Ser Leu Ser Leu Gln Gln Ala Phe Ser Glu Leu Arg Arg
            1300                1305                1310        
Ala Gln Met Thr Glu Gly Pro Asn Thr Ala Pro Pro Asn Phe Ser His
        1315                1320                1325            
Thr Gly Pro Thr Phe Pro Val Val Pro Pro Phe Leu Ser Ser Ile Ala
    1330                1335                1340                
Gly Val Pro Thr Thr Ala Ala Ala Thr Ala Pro Val Pro Ala Thr Ser
1345                1350                1355                1360
Ser Pro Pro Asn Asp Ile Ser Thr Ser Val Ile Gln Ser Glu Val Thr
                1365                1370                1375    
Val Pro Thr Glu Glu Gly Ile Ala Gly Val Ala Thr Ser Thr Gly Val
            1380                1385                1390        
Val Thr Ser Gly Gly Leu Pro Ile Pro Pro Val Ser Glu Ser Pro Val
        1395                1400                1405            
Leu Ser Ser Val Val Ser Ser Ile Thr Ile Pro Ala Val Val Ser Ile
    1410                1415                1420                
Ser Thr Thr Ser Pro Ser Leu Gln Val Pro Thr Ser Thr Ser Glu Ile
1425                1430                1435                1440
Val Val Ser Ser Thr Ala Leu Tyr Pro Ser Val Thr Val Ser Ala Thr
                1445                1450                1455    
Ser Ala Ser Ala Gly Gly Ser Thr Ala Thr Pro Gly Pro Lys Pro Pro
            1460                1465                1470        
Ala Val Val Ser Gln Gln Ala Ala Gly Ser Thr Thr Val Gly Ala Thr
        1475                1480                1485            
Leu Thr Ser Val Ser Thr Thr Thr Ser Phe Pro Ser Thr Ala Ser Gln
    1490                1495                1500                
Leu Ser Ile Gln Leu Ser Ser Ser Thr Ser Thr Pro Thr Leu Ala Glu
1505                1510                1515                1520
Thr Val Val Val Ser Ala His Ser Leu Asp Lys Thr Ser His Ser Ser
                1525                1530                1535    
Thr Thr Gly Leu Ala Phe Ser Leu Ser Ala Pro Ser Ser Ser Ser Ser
            1540                1545                1550        
Pro Gly Ala Gly Val Ser Ser Tyr Ile Ser Gln Pro Gly Gly Leu His
        1555                1560                1565            
Pro Leu Val Ile Pro Ser Val Ile Ala Ser Thr Pro Ile Leu Pro Gln
    1570                1575                1580                
Ala Ala Gly Pro Thr Ser Thr Pro Leu Leu Pro Gln Val Pro Ser Ile
1585                1590                1595                1600
Pro Pro Leu Val Gln Pro Val Ala Asn Val Pro Ala Val Gln Gln Thr
                1605                1610                1615    
Leu Ile His Ser Gln Pro Gln Pro Ala Leu Leu Pro Asn Gln Pro His
            1620                1625                1630        
Thr His Cys Pro Glu Val Asp Ser Asp Thr Gln Pro Lys Ala Pro Gly
        1635                1640                1645            
Ile Asp Asp Ile Lys Thr Leu Glu Glu Lys Leu Arg Ser Leu Phe Ser
    1650                1655                1660                
Glu His Ser Ser Ser Gly Ala Gln His Ala Ser Val Ser Leu Glu Thr
1665                1670                1675                1680
Ser Leu Val Ile Glu Ser Thr Val Thr Pro Gly Ile Pro Thr Thr Ala
                1685                1690                1695    
Val Ala Pro Ser Lys Leu Leu Thr Ser Thr Thr Ser Thr Cys Leu Pro
            1700                1705                1710        
Pro Thr Asn Leu Pro Leu Gly Thr Val Ala Leu Pro Val Thr Pro Val
        1715                1720                1725            
Val Thr Pro Gly Gln Val Ser Thr Pro Val Ser Thr Thr Thr Ser Gly
    1730                1735                1740                
Val Lys Pro Gly Thr Ala Pro Ser Lys Pro Pro Leu Thr Lys Ala Pro
1745                1750                1755                1760
Val Leu Pro Val Gly Thr Glu Leu Pro Ala Gly Thr Leu Pro Ser Glu
                1765                1770                1775    
Gln Leu Pro Pro Phe Pro Gly Pro Ser Leu Thr Gln Ser Gln Gln Pro
            1780                1785                1790        
Leu Glu Asp Leu Asp Ala Gln Leu Arg Arg Thr Leu Ser Pro Glu Ile
        1795                1800                1805            
Ile Thr Val Thr Ser Ala Val Gly Pro Val Ser Met Ala Ala Pro Thr
    1810                1815                1820                
Ala Ile Thr Glu Ala Gly Thr Gln Pro Gln Lys Gly Val Ser Gln Val
1825                1830                1835                1840
Lys Glu Gly Pro Val Leu Ala Thr Ser Ser Gly Ala Gly Val Phe Lys
                1845                1850                1855    
Met Gly Arg Phe Gln Val Ser Val Ala Ala Asp Gly Ala Gln Lys Glu
            1860                1865                1870        
Gly Lys Asn Lys Ser Glu Asp Ala Lys Ser Val His Phe Glu Ser Ser
        1875                1880                1885            
Thr Ser Glu Ser Ser Val Leu Ser Ser Ser Ser Pro Glu Ser Thr Leu
    1890                1895                1900                
Val Lys Pro Glu Pro Asn Gly Ile Thr Ile Pro Gly Ile Ser Ser Asp
1905                1910                1915                1920
Val Pro Glu Ser Ala His Lys Thr Thr Ala Ser Glu Ala Lys Ser Asp
                1925                1930                1935    
Thr Gly Gln Pro Thr Lys Val Gly Arg Phe Gln Val Thr Thr Thr Ala
            1940                1945                1950        
Asn Lys Val Gly Arg Phe Ser Val Ser Lys Thr Glu Asp Lys Ile Thr
        1955                1960                1965            
Asp Thr Lys Lys Glu Gly Pro Val Ala Ser Pro Pro Phe Met Asp Leu
    1970                1975                1980                
Glu Gln Ala Val Leu Pro Ala Val Ile Pro Lys Lys Glu Lys Pro Glu
1985                1990                1995                2000
Leu Ser Glu Pro Ser His Leu Asn Gly Pro Ser Ser Asp Pro Glu Ala
                2005                2010                2015    
Ala Phe Leu Ser Arg Asp Val Asp Asp Gly Ser Gly Ser Pro His Ser
            2020                2025                2030        
Pro His Gln Leu Ser Ser Lys Ser Leu Pro Ser Gln Asn Leu Ser Gln
        2035                2040                2045            
Ser Leu Ser Asn Ser Phe Asn Ser Ser Tyr Met Ser Ser Asp Asn Glu
    2050                2055                2060                
Ser Asp Ile Glu Asp Glu Asp Leu Lys Leu Glu Leu Arg Arg Leu Arg
2065                2070                2075                2080
Asp Lys His Leu Lys Glu Ile Gln Asp Leu Gln Ser Arg Gln Lys His
                2085                2090                2095    
Glu Ile Glu Ser Leu Tyr Thr Lys Leu Gly Lys Val Pro Pro Ala Val
            2100                2105                2110        
Ile Ile Pro Pro Ala Ala Pro Leu Ser Gly Arg Arg Arg Arg Pro Thr
        2115                2120                2125            
Lys Ser Lys Gly Ser Lys Ser Ser Arg Ser Ser Ser Leu Gly Asn Lys
    2130                2135                2140                
Ser Pro Gln Leu Ser Gly Asn Leu Ser Gly Gln Ser Ala Ala Ser Val
2145                2150                2155                2160
Leu His Pro Gln Gln Thr Leu His Pro Pro Gly Asn Ile Pro Glu Ser
                2165                2170                2175    
Gly Gln Asn Gln Leu Leu Gln Pro Leu Lys Pro Ser Pro Ser Ser Asp
            2180                2185                2190        
Asn Leu Tyr Ser Ala Phe Thr Ser Asp Gly Ala Ile Ser Val Pro Ser
        2195                2200                2205            
Leu Ser Ala Pro Gly Gln Gly Thr Ser Ser Thr Asn Thr Val Gly Ala
    2210                2215                2220                
Thr Val Asn Ser Gln Ala Ala Gln Ala Gln Pro Pro Ala Met Thr Ser
2225                2230                2235                2240
Ser Arg Lys Gly Thr Phe Thr Asp Asp Leu His Lys Leu Val Asp Asn
                2245                2250                2255    
Trp Ala Arg Asp Ala Met Asn Leu Ser Gly Arg Arg Gly Ser Lys Gly
            2260                2265                2270        
His Met Asn Tyr Glu Gly Pro Gly Met Ala Arg Lys Phe Ser Ala Pro
        2275                2280                2285            
Gly Gln Leu Cys Ile Ser Met Thr Ser Asn Leu Gly Gly Ser Ala Pro
    2290                2295                2300                
Ile Ser Ala Ala Ser Ala Thr Ser Leu Gly His Phe Thr Lys Ser Met
2305                2310                2315                2320
Cys Pro Pro Gln Gln Tyr Gly Phe Pro Ala Thr Pro Phe Gly Ala Gln
                2325                2330                2335    
Trp Ser Gly Thr Gly Gly Pro Ala Pro Gln Pro Leu Gly Gln Phe Gln
            2340                2345                2350        
Pro Val Gly Thr Ala Ser Leu Gln Asn Phe Asn Ile Ser Asn Leu Gln
        2355                2360                2365            
Lys Ser Ile Ser Asn Pro Pro Gly Ser Asn Leu Arg Thr Thr
    2370                2375                2380        


<210> 1405
<211> 335
<212> PRT
<213> Homo sapiens

<400> 1405
Met Ala Gly Ser Pro Thr Cys Leu Thr Leu Ile Tyr Ile Leu Trp Gln
 1               5                  10                  15      
Leu Thr Gly Ser Ala Ala Ser Gly Pro Val Lys Glu Leu Val Gly Ser
            20                  25                  30          
Val Gly Gly Ala Val Thr Phe Pro Leu Lys Ser Lys Val Lys Gln Val
        35                  40                  45              
Asp Ser Ile Val Trp Thr Phe Asn Thr Thr Pro Leu Val Thr Ile Gln
    50                  55                  60                  
Pro Glu Gly Gly Thr Ile Ile Val Thr Gln Asn Arg Asn Arg Glu Arg
65                  70                  75                  80  
Val Asp Phe Pro Asp Gly Gly Tyr Ser Leu Lys Leu Ser Lys Leu Lys
                85                  90                  95      
Lys Asn Asp Ser Gly Ile Tyr Tyr Val Gly Ile Tyr Ser Ser Ser Leu
            100                 105                 110         
Gln Gln Pro Ser Thr Gln Glu Tyr Val Leu His Val Tyr Glu His Leu
        115                 120                 125             
Ser Lys Pro Lys Val Thr Leu Gly Leu Gln Ser Asn Lys Asn Gly Thr
    130                 135                 140                 
Cys Val Thr Asn Leu Thr Cys Cys Met Glu His Gly Glu Glu Asp Val
145                 150                 155                 160 
Ile Tyr Thr Trp Lys Ala Leu Gly Gln Ala Ala Asn Glu Ser His Asn
                165                 170                 175     
Gly Ser Ile Leu Pro Ile Ser Trp Arg Trp Gly Glu Ser Asp Met Thr
            180                 185                 190         
Phe Ile Cys Val Ala Arg Asn Pro Val Ser Arg Asn Phe Ser Ser Pro
        195                 200                 205             
Ile Leu Ala Arg Lys Leu Cys Glu Gly Ala Ala Asp Asp Pro Asp Ser
    210                 215                 220                 
Ser Met Val Leu Leu Cys Leu Leu Leu Val Pro Leu Leu Leu Ser Leu
225                 230                 235                 240 
Phe Val Leu Gly Leu Phe Leu Trp Phe Leu Lys Arg Glu Arg Gln Glu
                245                 250                 255     
Glu Tyr Ile Glu Glu Lys Lys Arg Val Asp Ile Cys Arg Glu Thr Pro
            260                 265                 270         
Asn Ile Cys Pro His Ser Gly Glu Asn Thr Glu Tyr Asp Thr Ile Pro
        275                 280                 285             
His Thr Asn Arg Thr Ile Leu Lys Glu Asp Pro Ala Asn Thr Val Tyr
    290                 295                 300                 
Ser Thr Val Glu Ile Pro Lys Lys Met Glu Asn Pro His Ser Leu Leu
305                 310                 315                 320 
Thr Met Pro Asp Thr Pro Arg Leu Phe Ala Tyr Glu Asn Val Ile
                325                 330                 335 


<210> 1406
<211> 470
<212> PRT
<213> Homo sapiens

<400> 1406
Met Lys Glu Glu Lys Glu His Arg Pro Lys Glu Lys Arg Val Thr Leu
 1               5                  10                  15      
Leu Thr Pro Ala Gly Ala Thr Gly Ser Gly Gly Gly Thr Ser Gly Asp
            20                  25                  30          
Ser Ser Lys Gly Glu Asp Lys Gln Asp Arg Asn Lys Glu Lys Lys Glu
        35                  40                  45              
Ala Leu Ser Lys Val Val Ile Arg Arg Leu Pro Pro Thr Leu Thr Lys
    50                  55                  60                  
Glu Gln Leu Gln Glu His Leu Gln Pro Met Pro Glu His Asp Tyr Phe
65                  70                  75                  80  
Glu Phe Phe Ser Asn Asp Thr Ser Leu Tyr Pro His Met Tyr Ala Arg
                85                  90                  95      
Ala Tyr Ile Asn Phe Lys Asn Gln Glu Asp Ile Ile Leu Phe Arg Asp
            100                 105                 110         
Arg Phe Asp Gly Tyr Val Phe Leu Asp Asn Lys Gly Gln Glu Tyr Pro
        115                 120                 125             
Ala Ile Val Glu Phe Ala Pro Phe Gln Lys Ala Ala Lys Lys Lys Thr
    130                 135                 140                 
Lys Lys Arg Asp Thr Lys Val Gly Thr Ile Asp Asp Asp Pro Glu Tyr
145                 150                 155                 160 
Arg Lys Phe Leu Glu Ser Tyr Ala Thr Asp Asn Glu Lys Met Thr Ser
                165                 170                 175     
Thr Pro Glu Thr Leu Leu Glu Glu Ile Glu Ala Lys Asn Arg Glu Leu
            180                 185                 190         
Ile Ala Lys Lys Thr Thr Pro Leu Leu Ser Phe Leu Lys Asn Lys Gln
        195                 200                 205             
Arg Met Arg Glu Glu Lys Arg Glu Glu Arg Arg Arg Arg Glu Ile Glu
    210                 215                 220                 
Arg Lys Arg Gln Arg Glu Glu Glu Arg Arg Lys Trp Lys Glu Glu Glu
225                 230                 235                 240 
Lys Arg Lys Arg Lys Asp Ile Glu Lys Leu Lys Lys Ile Asp Arg Ile
                245                 250                 255     
Pro Glu Arg Asp Lys Leu Lys Asp Glu Pro Lys Ile Lys Leu Leu Lys
            260                 265                 270         
Lys Pro Glu Lys Gly Asp Glu Lys Glu Leu Asp Lys Arg Glu Lys Ala
        275                 280                 285             
Lys Lys Leu Asp Lys Glu Asn Leu Ser Asp Glu Arg Ala Ser Gly Gln
    290                 295                 300                 
Ser Cys Thr Leu Pro Lys Arg Ser Asp Ser Glu Leu Lys Asp Glu Lys
305                 310                 315                 320 
Pro Lys Arg Pro Glu Asp Glu Ser Gly Arg Asp Tyr Arg Glu Arg Glu
                325                 330                 335     
Arg Glu Tyr Glu Arg Asp Gln Glu Arg Ile Leu Arg Glu Arg Glu Arg
            340                 345                 350         
Leu Lys Arg Gln Glu Glu Glu Arg Arg Arg Gln Lys Glu Arg Tyr Glu
        355                 360                 365             
Lys Glu Lys Thr Phe Lys Arg Lys Glu Glu Glu Met Lys Lys Glu Lys
    370                 375                 380                 
Asp Thr Leu Arg Asp Lys Gly Lys Lys Ala Glu Ser Thr Glu Ser Ile
385                 390                 395                 400 
Gly Ser Ser Glu Lys Thr Glu Lys Lys Glu Glu Val Val Lys Arg Asp
                405                 410                 415     
Arg Ile Arg Asn Lys Asp Arg Pro Ala Met Gln Leu Tyr Gln Pro Gly
            420                 425                 430         
Ala Arg Ser Arg Asn Arg Leu Cys Pro Pro Asp Asp Ser Thr Lys Ser
        435                 440                 445             
Gly Asp Ser Ala Ala Glu Arg Lys Gln Glu Ser Gly Ile Ser His Arg
    450                 455                 460                 
Lys Glu Gly Gly Glu Glu
465                 470 


<210> 1407
<211> 1014
<212> PRT
<213> Homo sapiens

<400> 1407
Met Ala Glu Ser Ser Asp Lys Leu Tyr Arg Val Glu Tyr Ala Lys Ser
 1               5                  10                  15      
Gly Arg Ala Ser Cys Lys Lys Cys Ser Glu Ser Ile Pro Lys Asp Ser
            20                  25                  30          
Leu Arg Met Ala Ile Met Val Gln Ser Pro Met Phe Asp Gly Lys Val
        35                  40                  45              
Pro His Trp Tyr His Phe Ser Cys Phe Trp Lys Val Gly His Ser Ile
    50                  55                  60                  
Arg His Pro Asp Val Glu Val Asp Gly Phe Ser Glu Leu Arg Trp Asp
65                  70                  75                  80  
Asp Gln Gln Lys Val Lys Lys Thr Ala Glu Ala Gly Gly Val Thr Gly
                85                  90                  95      
Lys Gly Gln Asp Gly Ile Gly Ser Lys Ala Glu Lys Thr Leu Gly Asp
            100                 105                 110         
Phe Ala Ala Glu Tyr Ala Lys Ser Asn Arg Ser Thr Cys Lys Gly Cys
        115                 120                 125             
Met Glu Lys Ile Glu Lys Gly Gln Val Arg Leu Ser Lys Lys Met Val
    130                 135                 140                 
Asp Pro Glu Lys Pro Gln Leu Gly Met Ile Asp Arg Trp Tyr His Pro
145                 150                 155                 160 
Gly Cys Phe Val Lys Asn Arg Glu Glu Leu Gly Phe Arg Pro Glu Tyr
                165                 170                 175     
Ser Ala Ser Gln Leu Lys Gly Phe Ser Leu Leu Ala Thr Glu Asp Lys
            180                 185                 190         
Glu Ala Leu Lys Lys Gln Leu Pro Gly Val Lys Ser Glu Gly Lys Arg
        195                 200                 205             
Lys Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys Lys Ser
    210                 215                 220                 
Lys Lys Glu Lys Asp Lys Asp Ser Lys Leu Glu Lys Ala Leu Lys Ala
225                 230                 235                 240 
Gln Asn Asp Leu Ile Trp Asn Ile Lys Asp Glu Leu Lys Lys Val Cys
                245                 250                 255     
Ser Thr Asn Asp Leu Lys Glu Leu Leu Ile Phe Asn Lys Gln Gln Val
            260                 265                 270         
Pro Ser Gly Glu Ser Ala Ile Leu Asp Arg Val Ala Asp Gly Met Val
        275                 280                 285             
Phe Gly Ala Leu Leu Pro Cys Glu Glu Cys Ser Gly Gln Leu Val Phe
    290                 295                 300                 
Lys Ser Asp Ala Tyr Tyr Cys Thr Gly Asp Val Thr Ala Trp Thr Lys
305                 310                 315                 320 
Cys Met Val Lys Thr Gln Thr Pro Asn Arg Lys Glu Trp Val Thr Pro
                325                 330                 335     
Lys Glu Phe Arg Glu Ile Ser Tyr Leu Lys Lys Leu Lys Val Lys Lys
            340                 345                 350         
Gln Asp Arg Ile Phe Pro Pro Glu Thr Ser Ala Ser Val Ala Ala Thr
        355                 360                 365             
Pro Pro Pro Ser Thr Ala Ser Ala Pro Ala Ala Val Asn Ser Ser Ala
    370                 375                 380                 
Ser Ala Asp Lys Pro Leu Ser Asn Met Lys Ile Leu Thr Leu Gly Lys
385                 390                 395                 400 
Leu Ser Arg Asn Lys Asp Glu Val Lys Ala Met Ile Glu Lys Leu Gly
                405                 410                 415     
Gly Lys Leu Thr Gly Thr Ala Asn Lys Ala Ser Leu Cys Ile Ser Thr
            420                 425                 430         
Lys Lys Glu Val Glu Lys Met Asn Lys Lys Met Glu Glu Val Lys Glu
        435                 440                 445             
Ala Asn Ile Arg Val Val Ser Glu Asp Phe Leu Gln Asp Val Ser Ala
    450                 455                 460                 
Ser Thr Lys Ser Leu Gln Glu Leu Phe Leu Ala His Ile Leu Ser Pro
465                 470                 475                 480 
Trp Gly Ala Glu Val Lys Ala Glu Pro Val Glu Val Val Ala Pro Arg
                485                 490                 495     
Gly Lys Ser Gly Ala Ala Leu Ser Lys Lys Ser Lys Gly Gln Val Lys
            500                 505                 510         
Glu Glu Gly Ile Asn Lys Ser Glu Lys Arg Met Lys Leu Thr Leu Lys
        515                 520                 525             
Gly Gly Ala Ala Val Asp Pro Asp Ser Gly Leu Glu His Ser Ala His
    530                 535                 540                 
Val Leu Glu Lys Gly Gly Lys Val Phe Ser Ala Thr Leu Gly Leu Val
545                 550                 555                 560 
Asp Ile Val Lys Gly Thr Asn Ser Tyr Tyr Lys Leu Gln Leu Leu Glu
                565                 570                 575     
Asp Asp Lys Glu Asn Arg Tyr Trp Ile Phe Arg Ser Trp Gly Arg Val
            580                 585                 590         
Gly Thr Val Ile Gly Ser Asn Lys Leu Glu Gln Met Pro Ser Lys Glu
        595                 600                 605             
Asp Ala Ile Glu His Phe Met Lys Leu Tyr Glu Glu Lys Thr Gly Asn
    610                 615                 620                 
Ala Trp His Ser Lys Asn Phe Thr Lys Tyr Pro Lys Lys Phe Tyr Pro
625                 630                 635                 640 
Leu Glu Ile Asp Tyr Gly Gln Asp Glu Glu Ala Val Lys Lys Leu Thr
                645                 650                 655     
Val Asn Pro Gly Thr Lys Ser Lys Leu Pro Lys Pro Val Gln Asp Leu
            660                 665                 670         
Ile Lys Met Ile Phe Asp Val Glu Ser Met Lys Lys Ala Met Val Glu
        675                 680                 685             
Tyr Glu Ile Asp Leu Gln Lys Met Pro Leu Gly Lys Leu Ser Lys Arg
    690                 695                 700                 
Gln Ile Gln Ala Ala Tyr Ser Ile Leu Ser Glu Val Gln Gln Ala Val
705                 710                 715                 720 
Ser Gln Gly Ser Ser Asp Ser Gln Ile Leu Asp Leu Ser Asn Arg Phe
                725                 730                 735     
Tyr Thr Leu Ile Pro His Asp Phe Gly Met Lys Lys Pro Pro Leu Leu
            740                 745                 750         
Asn Asn Ala Asp Ser Val Gln Ala Lys Val Glu Met Leu Asp Asn Leu
        755                 760                 765             
Leu Asp Ile Glu Val Ala Tyr Ser Leu Leu Arg Gly Gly Ser Asp Asp
    770                 775                 780                 
Ser Ser Lys Asp Pro Ile Asp Val Asn Tyr Glu Lys Leu Lys Thr Asp
785                 790                 795                 800 
Ile Lys Val Val Asp Arg Asp Ser Glu Glu Ala Glu Ile Ile Arg Lys
                805                 810                 815     
Tyr Val Lys Asn Thr His Ala Thr Thr His Asn Ala Tyr Asp Leu Glu
            820                 825                 830         
Val Ile Asp Ile Phe Lys Ile Glu Arg Glu Gly Glu Cys Gln Arg Tyr
        835                 840                 845             
Lys Pro Phe Lys Gln Leu His Asn Arg Arg Leu Leu Trp His Gly Ser
    850                 855                 860                 
Arg Thr Thr Asn Phe Ala Gly Ile Leu Ser Gln Gly Leu Arg Ile Ala
865                 870                 875                 880 
Pro Pro Glu Ala Pro Val Thr Gly Tyr Met Phe Gly Lys Gly Ile Tyr
                885                 890                 895     
Phe Ala Asp Met Val Ser Lys Ser Ala Asn Tyr Cys His Thr Ser Gln
            900                 905                 910         
Gly Asp Pro Ile Gly Leu Ile Leu Leu Gly Glu Val Ala Leu Gly Asn
        915                 920                 925             
Met Tyr Glu Leu Lys His Ala Ser His Ile Ser Lys Leu Pro Lys Gly
    930                 935                 940                 
Lys His Ser Val Lys Gly Leu Gly Lys Thr Thr Pro Asp Pro Ser Ala
945                 950                 955                 960 
Asn Ile Ser Leu Asp Gly Val Asp Val Pro Leu Gly Thr Gly Ile Ser
                965                 970                 975     
Ser Gly Val Asn Asp Thr Ser Leu Leu Tyr Asn Glu Tyr Ile Val Tyr
            980                 985                 990         
Asp Ile Ala Gln Val Asn Leu Lys Tyr Leu Leu Lys Leu Lys Phe Asn
        995                 1000                1005            
Phe Lys Thr Ser Leu Trp
    1010                


<210> 1408
<211> 1224
<212> PRT
<213> Homo sapiens

<400> 1408
Met Glu Pro Leu Leu Leu Gly Arg Gly Leu Ile Val Tyr Leu Met Phe
 1               5                  10                  15      
Leu Leu Leu Lys Phe Ser Lys Ala Ile Glu Ile Pro Ser Ser Val Gln
            20                  25                  30          
Gln Val Pro Thr Ile Ile Lys Gln Ser Lys Val Gln Val Ala Phe Pro
        35                  40                  45              
Phe Asp Glu Tyr Phe Gln Ile Glu Cys Glu Ala Lys Gly Asn Pro Glu
    50                  55                  60                  
Pro Thr Phe Ser Trp Thr Lys Asp Gly Asn Pro Phe Tyr Phe Thr Asp
65                  70                  75                  80  
His Arg Ile Ile Pro Ser Asn Asn Ser Gly Thr Phe Arg Ile Pro Asn
                85                  90                  95      
Glu Gly His Ile Ser His Phe Gln Gly Lys Tyr Arg Cys Phe Ala Ser
            100                 105                 110         
Asn Lys Leu Gly Ile Ala Met Ser Glu Glu Ile Glu Phe Ile Val Pro
        115                 120                 125             
Ser Val Pro Lys Phe Pro Lys Glu Lys Ile Asp Pro Leu Glu Val Glu
    130                 135                 140                 
Glu Gly Asp Pro Ile Val Leu Pro Cys Asn Pro Pro Lys Gly Leu Pro
145                 150                 155                 160 
Pro Leu His Ile Tyr Trp Met Asn Ile Glu Leu Glu His Ile Glu Gln
                165                 170                 175     
Asp Glu Arg Val Tyr Met Ser Gln Lys Gly Asp Leu Tyr Phe Ala Asn
            180                 185                 190         
Val Glu Glu Lys Asp Ser Arg Asn Asp Tyr Cys Cys Phe Ala Ala Phe
        195                 200                 205             
Pro Arg Leu Arg Thr Ile Val Gln Lys Met Pro Met Lys Leu Thr Val
    210                 215                 220                 
Asn Ser Leu Lys His Ala Asn Asp Ser Ser Ser Ser Thr Glu Ile Gly
225                 230                 235                 240 
Ser Lys Ala Asn Ser Ile Lys Gln Arg Lys Pro Lys Leu Leu Leu Pro
                245                 250                 255     
Pro Thr Glu Ser Gly Ser Glu Ser Ser Ile Thr Ile Leu Lys Gly Glu
            260                 265                 270         
Ile Leu Leu Leu Glu Cys Phe Ala Glu Gly Leu Pro Thr Pro Gln Val
        275                 280                 285             
Asp Trp Asn Lys Ile Gly Gly Asp Leu Pro Lys Gly Arg Glu Thr Lys
    290                 295                 300                 
Glu Asn Tyr Gly Lys Thr Leu Lys Ile Glu Asn Val Ser Tyr Gln Asp
305                 310                 315                 320 
Lys Gly Asn Tyr Arg Cys Thr Ala Ser Asn Phe Leu Gly Thr Ala Thr
                325                 330                 335     
His Asp Phe His Val Ile Val Glu Glu Pro Pro Arg Trp Thr Lys Lys
            340                 345                 350         
Pro Gln Ser Ala Val Tyr Ser Thr Gly Ser Asn Gly Ile Leu Leu Cys
        355                 360                 365             
Glu Ala Glu Gly Glu Pro Gln Pro Thr Ile Lys Trp Arg Val Asn Gly
    370                 375                 380                 
Ser Pro Val Asp Asn His Pro Phe Ala Gly Asp Val Val Phe Pro Arg
385                 390                 395                 400 
Glu Ile Ser Phe Thr Asn Leu Gln Pro Asn His Thr Ala Val Tyr Gln
                405                 410                 415     
Cys Glu Ala Ser Asn Val His Gly Thr Ile Leu Ala Asn Ala Asn Ile
            420                 425                 430         
Asp Val Val Asp Val Arg Pro Leu Ile Gln Thr Lys Asp Gly Glu Asn
        435                 440                 445             
Tyr Ala Thr Val Val Gly Tyr Ser Ala Phe Leu His Cys Glu Phe Phe
    450                 455                 460                 
Ala Ser Pro Glu Ala Val Val Ser Trp Gln Lys Val Glu Glu Val Lys
465                 470                 475                 480 
Pro Leu Glu Gly Arg Arg Tyr His Ile Tyr Glu Asn Gly Thr Leu Gln
                485                 490                 495     
Ile Asn Arg Thr Thr Glu Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val
            500                 505                 510         
Glu Asn Ala Ile Gly Lys Thr Ala Val Thr Ala Asn Leu Asp Ile Arg
        515                 520                 525             
Asn Ala Thr Lys Leu Arg Val Ser Pro Lys Asn Pro Arg Ile Pro Lys
    530                 535                 540                 
Leu His Met Leu Glu Leu His Cys Glu Ser Lys Cys Asp Ser His Leu
545                 550                 555                 560 
Lys His Ser Leu Lys Leu Ser Trp Ser Lys Asp Gly Glu Ala Phe Glu
                565                 570                 575     
Ile Asn Gly Thr Glu Asp Gly Arg Ile Ile Ile Asp Gly Ala Asn Leu
            580                 585                 590         
Thr Ile Ser Asn Val Thr Leu Glu Asp Gln Gly Ile Tyr Cys Cys Ser
        595                 600                 605             
Ala His Thr Ala Leu Asp Ser Ala Ala Asp Ile Thr Gln Val Thr Val
    610                 615                 620                 
Leu Asp Val Pro Asp Pro Pro Glu Asn Leu His Leu Ser Glu Arg Gln
625                 630                 635                 640 
Asn Arg Ser Val Arg Leu Thr Trp Glu Ala Gly Ala Asp His Asn Ser
                645                 650                 655     
Asn Ile Ser Glu Tyr Ile Val Glu Phe Glu Gly Asn Lys Glu Glu Pro
            660                 665                 670         
Gly Arg Trp Glu Glu Leu Thr Arg Val Gln Gly Lys Lys Thr Thr Val
        675                 680                 685             
Ile Leu Pro Leu Ala Pro Phe Val Arg Tyr Gln Phe Arg Val Ile Ala
    690                 695                 700                 
Val Asn Glu Val Gly Arg Ser Gln Pro Ser Gln Pro Ser Asp His His
705                 710                 715                 720 
Glu Thr Pro Pro Ala Ala Pro Asp Arg Asn Pro Gln Asn Ile Arg Val
                725                 730                 735     
Gln Ala Ser Gln Pro Lys Glu Met Ile Ile Lys Trp Glu Pro Leu Lys
            740                 745                 750         
Ser Met Glu Gln Asn Gly Pro Gly Leu Glu Tyr Arg Val Thr Trp Lys
        755                 760                 765             
Pro Gln Gly Ala Pro Val Glu Trp Glu Glu Glu Thr Val Thr Asn His
    770                 775                 780                 
Thr Leu Arg Val Met Thr Pro Ala Val Tyr Ala Pro Tyr Asp Val Lys
785                 790                 795                 800 
Val Gln Ala Ile Asn Gln Leu Gly Ser Gly Pro Asp Pro Gln Ser Val
                805                 810                 815     
Thr Leu Tyr Ser Gly Glu Asp Tyr Pro Asp Thr Ala Pro Val Ile His
            820                 825                 830         
Gly Val Asp Val Ile Asn Ser Thr Leu Val Lys Val Thr Trp Ser Thr
        835                 840                 845             
Val Pro Lys Asp Arg Val His Gly Arg Leu Lys Gly Tyr Gln Ile Asn
    850                 855                 860                 
Trp Trp Lys Thr Lys Ser Leu Leu Asp Gly Arg Thr His Pro Lys Glu
865                 870                 875                 880 
Val Asn Ile Leu Arg Phe Ser Gly Gln Arg Asn Ser Gly Met Val Pro
                885                 890                 895     
Ser Leu Asp Ala Phe Ser Glu Phe His Leu Thr Val Leu Ala Tyr Asn
            900                 905                 910         
Ser Lys Gly Ala Gly Pro Glu Ser Glu Pro Tyr Ile Phe Gln Thr Pro
        915                 920                 925             
Glu Gly Val Pro Glu Gln Pro Thr Phe Leu Lys Val Ile Lys Val Asp
    930                 935                 940                 
Lys Asp Thr Ala Thr Leu Ser Trp Gly Leu Pro Lys Lys Leu Asn Gly
945                 950                 955                 960 
Asn Leu Thr Gly Tyr Leu Leu Gln Tyr Gln Ile Ile Asn Asp Thr Tyr
                965                 970                 975     
Glu Ile Gly Glu Leu Asn Asp Ile Asn Ile Thr Thr Pro Ser Lys Pro
            980                 985                 990         
Ser Trp His Leu Ser Asn Leu Asn Ala Thr Thr Lys Tyr Lys Phe Tyr
        995                 1000                1005            
Leu Arg Ala Cys Thr Ser Gln Gly Cys Gly Lys Pro Ile Thr Glu Glu
    1010                1015                1020                
Ser Ser Thr Leu Gly Glu Gly Ser Lys Gly Ile Gly Lys Ile Ser Gly
1025                1030                1035                1040
Val Asn Leu Thr Gln Lys Thr His Pro Ile Glu Val Phe Glu Pro Gly
                1045                1050                1055    
Ala Glu His Ile Val Arg Leu Met Thr Lys Asn Trp Gly Asp Asn Asp
            1060                1065                1070        
Ser Ile Phe Gln Asp Val Ile Glu Thr Arg Gly Arg Glu Tyr Ala Gly
        1075                1080                1085            
Leu Tyr Asp Asp Ile Ser Thr Gln Gly Trp Phe Ile Gly Leu Met Cys
    1090                1095                1100                
Ala Ile Ala Leu Leu Thr Leu Leu Leu Leu Thr Val Cys Phe Val Lys
1105                1110                1115                1120
Arg Asn Arg Gly Gly Lys Tyr Ser Val Lys Glu Lys Glu Asp Leu His
                1125                1130                1135    
Pro Asp Pro Glu Ile Gln Ser Val Lys Asp Glu Thr Phe Gly Glu Tyr
            1140                1145                1150        
Ser Asp Ser Asp Glu Lys Pro Leu Lys Gly Ser Leu Arg Ser Leu Asn
        1155                1160                1165            
Arg Asp Met Gln Pro Thr Glu Ser Ala Asp Ser Leu Val Glu Tyr Gly
    1170                1175                1180                
Glu Gly Asp His Gly Leu Phe Ser Glu Asp Gly Ser Phe Ile Gly Ala
1185                1190                1195                1200
Tyr Ala Gly Ser Lys Glu Lys Gly Ser Val Glu Ser Asn Gly Ser Ser
                1205                1210                1215    
Thr Ala Thr Phe Pro Leu Arg Ala
            1220                


<210> 1409
<211> 481
<212> PRT
<213> Homo sapiens

<400> 1409
Met Asp Asp Phe Glu Arg Arg Arg Glu Leu Arg Arg Gln Lys Arg Glu
 1               5                  10                  15      
Glu Met Arg Leu Glu Ala Glu Arg Ile Ala Tyr Gln Arg Asn Asp Asp
            20                  25                  30          
Asp Glu Glu Glu Ala Ala Arg Glu Arg Arg Arg Arg Ala Arg Gln Glu
        35                  40                  45              
Arg Leu Arg Gln Lys Gln Glu Glu Glu Ser Leu Gly Gln Val Thr Asp
    50                  55                  60                  
Gln Val Glu Val Asn Ala Gln Asn Ser Val Pro Asp Glu Glu Ala Lys
65                  70                  75                  80  
Thr Thr Thr Thr Asn Thr Gln Val Glu Gly Asp Asp Glu Ala Ala Phe
                85                  90                  95      
Leu Glu Arg Leu Ala Arg Arg Glu Glu Arg Arg Gln Lys Arg Leu Gln
            100                 105                 110         
Glu Ala Leu Glu Arg Gln Lys Glu Phe Asp Pro Thr Ile Thr Asp Ala
        115                 120                 125             
Ser Leu Ser Leu Pro Ser Arg Arg Met Gln Asn Asp Thr Ala Glu Asn
    130                 135                 140                 
Glu Thr Thr Glu Lys Glu Glu Lys Ser Glu Ser Arg Gln Glu Arg Tyr
145                 150                 155                 160 
Glu Ile Glu Glu Thr Glu Thr Val Thr Lys Ser Tyr Gln Lys Asn Asp
                165                 170                 175     
Trp Arg Asp Ala Glu Glu Asn Lys Lys Glu Asp Lys Glu Lys Glu Glu
            180                 185                 190         
Glu Glu Glu Glu Lys Pro Lys Arg Gly Ser Ile Gly Glu Asn Gln Ile
        195                 200                 205             
Lys Asp Glu Lys Ile Lys Lys Asp Lys Glu Pro Lys Glu Glu Val Lys
    210                 215                 220                 
Ser Phe Met Asp Arg Lys Lys Gly Phe Thr Glu Val Lys Ser Gln Asn
225                 230                 235                 240 
Gly Glu Phe Met Thr His Lys Leu Lys His Thr Glu Asn Thr Phe Ser
                245                 250                 255     
Arg Pro Gly Gly Arg Ala Ser Val Asp Thr Lys Glu Ala Glu Gly Ala
            260                 265                 270         
Pro Gln Val Glu Ala Gly Lys Arg Leu Glu Glu Leu Arg Arg Arg Arg
        275                 280                 285             
Gly Glu Thr Glu Ser Glu Glu Phe Glu Lys Leu Lys Gln Lys Gln Gln
    290                 295                 300                 
Glu Ala Ala Leu Glu Leu Glu Glu Leu Lys Lys Lys Arg Glu Glu Arg
305                 310                 315                 320 
Arg Lys Val Leu Glu Glu Glu Glu Gln Arg Arg Lys Gln Glu Glu Ala
                325                 330                 335     
Asp Arg Lys Leu Arg Glu Glu Glu Glu Lys Arg Arg Leu Lys Glu Glu
            340                 345                 350         
Ile Glu Arg Arg Arg Ala Glu Ala Ala Glu Lys Arg Gln Lys Met Pro
        355                 360                 365             
Glu Asp Gly Leu Ser Asp Asp Lys Lys Pro Phe Lys Cys Phe Thr Pro
    370                 375                 380                 
Lys Gly Ser Ser Leu Lys Ile Glu Glu Arg Ala Glu Phe Leu Asn Lys
385                 390                 395                 400 
Ser Val Gln Lys Ser Ser Gly Val Lys Ser Thr His Gln Ala Ala Ile
                405                 410                 415     
Val Ser Lys Ile Asp Ser Arg Leu Glu Gln Tyr Thr Ser Ala Ile Glu
            420                 425                 430         
Gly Thr Lys Ser Ala Lys Pro Thr Lys Pro Ala Ala Ser Asp Leu Pro
        435                 440                 445             
Val Pro Ala Glu Gly Val Arg Asn Ile Lys Ser Met Trp Glu Lys Gly
    450                 455                 460                 
Asn Val Phe Ser Ser Pro Thr Ala Ala Gly Thr Pro Asn Lys Val Ser
465                 470                 475                 480 
Ile
    


<210> 1410
<211> 567
<212> PRT
<213> Homo sapiens

<400> 1410
Met Leu Glu Arg Arg Cys Arg Gly Pro Leu Ala Met Gly Leu Ala Gln
 1               5                  10                  15      
Pro Arg Leu Leu Ser Gly Pro Ser Gln Glu Ser Pro Gln Thr Leu Gly
            20                  25                  30          
Lys Glu Ser Arg Gly Leu Arg Gln Gln Gly Thr Ser Val Ala Gln Ser
        35                  40                  45              
Gly Ala Gln Ala Pro Gly Arg Ala His Arg Cys Ala His Cys Arg Arg
    50                  55                  60                  
His Phe Pro Gly Trp Val Ala Leu Trp Leu His Thr Arg Arg Cys Gln
65                  70                  75                  80  
Ala Arg Leu Pro Leu Pro Cys Pro Glu Cys Gly Arg Arg Phe Arg His
                85                  90                  95      
Ala Pro Phe Leu Ala Leu His Arg Gln Val His Ala Ala Ala Thr Pro
            100                 105                 110         
Asp Leu Gly Phe Ala Cys His Leu Cys Gly Gln Ser Phe Arg Gly Trp
        115                 120                 125             
Val Ala Leu Val Leu His Leu Arg Ala His Ser Ala Ala Lys Arg Pro
    130                 135                 140                 
Ile Ala Cys Pro Lys Cys Glu Arg Arg Phe Trp Arg Arg Lys Gln Leu
145                 150                 155                 160 
Arg Ala His Leu Arg Arg Cys His Pro Pro Ala Pro Glu Ala Arg Pro
                165                 170                 175     
Phe Ile Cys Gly Asn Cys Gly Arg Ser Phe Ala Gln Trp Asp Gln Leu
            180                 185                 190         
Val Ala His Lys Arg Val His Val Ala Glu Ala Leu Glu Glu Ala Ala
        195                 200                 205             
Ala Lys Ala Leu Gly Pro Arg Pro Arg Gly Arg Pro Ala Val Thr Ala
    210                 215                 220                 
Pro Arg Pro Gly Gly Asp Ala Val Asp Arg Pro Phe Gln Cys Ala Cys
225                 230                 235                 240 
Cys Gly Lys Arg Phe Arg His Lys Pro Asn Leu Ile Ala His Arg Arg
                245                 250                 255     
Val His Thr Gly Glu Arg Pro His Gln Cys Pro Glu Cys Gly Lys Arg
            260                 265                 270         
Phe Thr Asn Lys Pro Tyr Leu Thr Ser His Arg Arg Ile His Thr Gly
        275                 280                 285             
Glu Lys Pro Tyr Pro Cys Lys Glu Cys Gly Arg Arg Phe Arg His Lys
    290                 295                 300                 
Pro Asn Leu Leu Ser His Ser Lys Ile His Lys Arg Ser Glu Gly Ser
305                 310                 315                 320 
Ala Gln Ala Ala Pro Gly Pro Gly Ser Pro Gln Leu Pro Ala Gly Pro
                325                 330                 335     
Gln Glu Ser Ala Ala Glu Pro Thr Pro Ala Val Pro Leu Lys Pro Ala
            340                 345                 350         
Gln Glu Pro Pro Pro Gly Ala Pro Pro Glu His Pro Gln Asp Pro Ile
        355                 360                 365             
Glu Ala Pro Pro Ser Leu Tyr Ser Cys Asp Asp Cys Gly Arg Ser Phe
    370                 375                 380                 
Arg Leu Glu Arg Phe Leu Arg Ala His Gln Arg Gln His Thr Gly Glu
385                 390                 395                 400 
Arg Pro Phe Thr Cys Ala Glu Cys Gly Lys Asn Phe Gly Lys Lys Thr
                405                 410                 415     
His Leu Val Ala His Ser Arg Val His Ser Gly Glu Arg Pro Phe Ala
            420                 425                 430         
Cys Glu Glu Cys Gly Arg Arg Phe Ser Gln Gly Ser His Leu Ala Ala
        435                 440                 445             
His Arg Arg Asp His Ala Pro Asp Arg Pro Phe Val Cys Pro Asp Cys
    450                 455                 460                 
Gly Lys Ala Phe Arg His Lys Pro Tyr Leu Ala Ala His Arg Arg Ile
465                 470                 475                 480 
His Thr Gly Glu Lys Pro Tyr Val Cys Pro Asp Cys Gly Lys Ala Phe
                485                 490                 495     
Ser Gln Lys Ser Asn Leu Val Ser His Arg Arg Ile His Thr Gly Glu
            500                 505                 510         
Arg Pro Tyr Ala Cys Pro Asp Cys Asp Arg Ser Phe Ser Gln Lys Ser
        515                 520                 525             
Asn Leu Ile Thr His Arg Lys Ser His Ile Arg Asp Gly Ala Phe Cys
    530                 535                 540                 
Cys Ala Ile Cys Gly Gln Thr Phe Asp Asp Glu Glu Arg Leu Leu Ala
545                 550                 555                 560 
His Gln Lys Lys His Asp Val
                565         


<210> 1411
<211> 316
<212> PRT
<213> Homo sapiens

<400> 1411
Met Gly Asn Arg His Ala Lys Ala Ser Ser Pro Gln Gly Phe Asp Val
 1               5                  10                  15      
Asp Arg Asp Ala Lys Lys Leu Asn Lys Ala Cys Lys Gly Met Gly Thr
            20                  25                  30          
Asn Glu Ala Ala Ile Ile Glu Ile Leu Ser Gly Arg Thr Ser Asp Glu
        35                  40                  45              
Arg Gln Gln Ile Lys Gln Lys Tyr Lys Ala Thr Tyr Gly Lys Glu Leu
    50                  55                  60                  
Glu Glu Val Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Lys Thr Ala
65                  70                  75                  80  
Leu Ala Leu Leu Asp Arg Pro Ser Glu Tyr Ala Ala Arg Gln Leu Gln
                85                  90                  95      
Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Ser Val Leu Ile Glu Val
            100                 105                 110         
Leu Cys Thr Arg Thr Asn Lys Glu Ile Ile Ala Ile Lys Glu Ala Tyr
        115                 120                 125             
Gln Arg Leu Phe Asp Arg Ser Leu Glu Ser Asp Val Lys Gly Asp Thr
    130                 135                 140                 
Ser Gly Asn Leu Lys Lys Ile Leu Val Ser Leu Leu Gln Ala Asn Arg
145                 150                 155                 160 
Asn Glu Gly Asp Asp Val Asp Lys Asp Leu Ala Gly Gln Asp Ala Lys
                165                 170                 175     
Asp Leu Tyr Asp Ala Gly Glu Gly Arg Trp Gly Thr Asp Glu Leu Ala
            180                 185                 190         
Phe Asn Glu Val Leu Ala Lys Arg Ser Tyr Lys Gln Leu Arg Ala Thr
        195                 200                 205             
Phe Gln Ala Tyr Gln Ile Leu Ile Gly Lys Asp Ile Glu Glu Ala Ile
    210                 215                 220                 
Glu Glu Glu Thr Ser Gly Asp Leu Gln Lys Ala Tyr Leu Thr Leu Val
225                 230                 235                 240 
Arg Ser Ala Gln Asp Cys Glu Asp Tyr Phe Ala Glu Arg Leu Tyr Lys
                245                 250                 255     
Ser Met Lys Gly Ala Gly Thr Asp Glu Glu Thr Leu Ile Arg Ile Ile
            260                 265                 270         
Val Thr Arg Ala Glu Val Asp Leu Gln Gly Ile Lys Ala Lys Phe Gln
        275                 280                 285             
Lys Lys Tyr Gln Lys Ser Leu Ser Asp Met Val Arg Ser Asp Thr Ser
    290                 295                 300                 
Gly Asp Phe Arg Lys Leu Leu Val Ala Leu Leu His
305                 310                 315     


<210> 1412
<211> 522
<212> PRT
<213> Homo sapiens

<400> 1412
Met Ala Ser Ser Arg Ala Ser Ser Thr Gln Ala Thr Lys Thr Lys Ala
 1               5                  10                  15      
Pro Asp Asp Leu Val Ala Pro Val Val Lys Lys Pro His Ile Tyr Tyr
            20                  25                  30          
Gly Ser Leu Glu Glu Lys Glu Arg Glu Arg Leu Ala Lys Gly Glu Ser
        35                  40                  45              
Gly Ile Leu Gly Lys Asp Gly Leu Lys Ala Gly Ile Glu Ala Gly Asn
    50                  55                  60                  
Ile Asn Ile Thr Ser Gly Glu Val Phe Glu Ile Glu Glu His Ile Ser
65                  70                  75                  80  
Glu Arg Gln Ala Glu Val Leu Ala Glu Phe Glu Arg Arg Lys Arg Ala
                85                  90                  95      
Arg Gln Ile Asn Val Ser Thr Asp Asp Ser Glu Val Lys Ala Cys Leu
            100                 105                 110         
Arg Ala Leu Gly Glu Pro Ile Thr Leu Phe Gly Glu Gly Pro Ala Glu
        115                 120                 125             
Arg Arg Glu Arg Leu Arg Asn Ile Leu Ser Val Val Gly Thr Asp Ala
    130                 135                 140                 
Leu Lys Lys Thr Lys Lys Asp Asp Glu Lys Ser Lys Lys Ser Lys Glu
145                 150                 155                 160 
Glu Tyr Gln Gln Thr Trp Tyr His Glu Gly Pro Asn Ser Leu Lys Val
                165                 170                 175     
Ala Arg Leu Trp Ile Ala Asn Tyr Ser Leu Pro Arg Ala Met Lys Arg
            180                 185                 190         
Leu Glu Glu Ala Arg Leu His Lys Glu Ile Pro Glu Thr Thr Arg Thr
        195                 200                 205             
Ser Gln Met Gln Glu Leu His Lys Ser Leu Arg Ser Leu Asn Asn Phe
    210                 215                 220                 
Cys Ser Gln Ile Gly Asp Asp Arg Pro Ile Ser Tyr Cys His Phe Ser
225                 230                 235                 240 
Pro Asn Ser Lys Met Leu Ala Thr Ala Cys Trp Ser Gly Leu Cys Lys
                245                 250                 255     
Leu Trp Ser Val Pro Asp Cys Asn Leu Leu His Thr Leu Arg Gly His
            260                 265                 270         
Asn Thr Asn Val Gly Ala Ile Val Phe His Pro Lys Ser Thr Val Ser
        275                 280                 285             
Leu Asp Pro Lys Asp Val Asn Leu Ala Ser Cys Ala Ala Asp Gly Ser
    290                 295                 300                 
Val Lys Leu Trp Ser Leu Asp Ser Asp Glu Pro Val Ala Asp Ile Glu
305                 310                 315                 320 
Gly His Thr Val Arg Val Ala Arg Val Met Trp His Pro Ser Gly Arg
                325                 330                 335     
Phe Leu Gly Thr Thr Cys Tyr Asp Arg Ser Trp Arg Leu Trp Asp Leu
            340                 345                 350         
Glu Ala Gln Glu Glu Ile Leu His Gln Glu Gly His Ser Met Gly Val
        355                 360                 365             
Tyr Asp Ile Ala Phe His Gln Asp Gly Ser Leu Ala Gly Thr Gly Gly
    370                 375                 380                 
Leu Asp Ala Phe Gly Arg Val Trp Asp Leu Arg Thr Gly Arg Cys Ile
385                 390                 395                 400 
Met Phe Leu Glu Gly His Leu Lys Glu Ile Tyr Gly Ile Asn Phe Ser
                405                 410                 415     
Pro Asn Gly Tyr His Ile Ala Thr Gly Ser Gly Asp Asn Thr Cys Lys
            420                 425                 430         
Val Trp Asp Leu Arg Gln Arg Arg Cys Val Tyr Thr Ile Pro Ala His
        435                 440                 445             
Gln Asn Leu Val Thr Gly Val Lys Phe Glu Pro Ile His Gly Asn Phe
    450                 455                 460                 
Leu Leu Thr Gly Ala Tyr Asp Asn Thr Ala Lys Ile Trp Thr His Pro
465                 470                 475                 480 
Gly Trp Ser Pro Leu Lys Thr Leu Ala Gly His Glu Gly Lys Val Met
                485                 490                 495     
Gly Leu Asp Ile Ser Ser Asp Gly Gln Leu Ile Ala Thr Cys Ser Tyr
            500                 505                 510         
Asp Arg Thr Phe Lys Leu Trp Met Ala Glu
        515                 520         


<210> 1413
<211> 361
<212> PRT
<213> Homo sapiens

<400> 1413
Met Ala Ser Leu Leu Ala Lys Asp Ala Tyr Leu Gln Ser Leu Ala Lys
 1               5                  10                  15      
Lys Ile Cys Ser His Ser Ala Pro Glu Gln Gln Ala Arg Thr Arg Ala
            20                  25                  30          
Gly Lys Thr Gln Gly Ser Glu Thr Ala Gly Pro Pro Lys Lys Lys Arg
        35                  40                  45              
Lys Lys Thr Gln Lys Lys Phe Arg Lys Arg Glu Glu Lys Ala Ala Glu
    50                  55                  60                  
His Lys Ala Lys Ser Leu Gly Glu Lys Ser Pro Ala Ala Ser Gly Ala
65                  70                  75                  80  
Arg Arg Pro Glu Ala Ala Lys Glu Glu Ala Ala Trp Ala Ser Ser Ser
                85                  90                  95      
Ala Gly Asn Pro Ala Asp Gly Leu Ala Thr Glu Pro Glu Ser Val Phe
            100                 105                 110         
Ala Leu Asp Val Leu Arg Gln Arg Leu His Glu Lys Ile Gln Glu Ala
        115                 120                 125             
Arg Gly Gln Gly Ser Ala Lys Glu Leu Ser Pro Ala Ala Leu Glu Lys
    130                 135                 140                 
Arg Arg Arg Arg Lys Gln Glu Arg Asp Arg Lys Lys Arg Lys Arg Lys
145                 150                 155                 160 
Glu Leu Arg Ala Lys Glu Lys Ala Arg Lys Ala Glu Glu Ala Thr Glu
                165                 170                 175     
Ala Gln Glu Val Val Glu Ala Thr Pro Glu Gly Ala Cys Thr Glu Pro
            180                 185                 190         
Arg Glu Pro Pro Gly Leu Ile Phe Asn Lys Val Glu Val Ser Glu Asp
        195                 200                 205             
Glu Pro Ala Ser Lys Ala Gln Arg Arg Lys Glu Lys Arg Gln Arg Val
    210                 215                 220                 
Lys Gly Asn Leu Thr Pro Leu Thr Gly Arg Asn Tyr Arg Gln Leu Leu
225                 230                 235                 240 
Glu Arg Leu Gln Ala Arg Gln Ser Arg Leu Asp Glu Leu Arg Gly Gln
                245                 250                 255     
Asp Glu Gly Lys Ala Gln Glu Leu Glu Ala Lys Met Lys Trp Thr Asn
            260                 265                 270         
Leu Leu Tyr Lys Ala Glu Gly Val Lys Ile Arg Asp Asp Glu Arg Leu
        275                 280                 285             
Leu Gln Glu Ala Leu Lys Arg Lys Glu Lys Arg Arg Ala Gln Arg Gln
    290                 295                 300                 
Arg Arg Trp Glu Lys Arg Thr Ala Gly Val Val Glu Lys Met Gln Gln
305                 310                 315                 320 
Arg Gln Asp Arg Arg Arg Gln Asn Leu Arg Arg Lys Lys Ala Ala Arg
                325                 330                 335     
Ala Glu Arg Arg Leu Leu Arg Ala Arg Lys Lys Gly Arg Ile Leu Pro
            340                 345                 350         
Gln Asp Leu Glu Arg Ala Gly Leu Val
        355                 360     


<210> 1414
<211> 227
<212> PRT
<213> Homo sapiens

<400> 1414
Met Gly Ala Ser Ala Arg Leu Leu Arg Ala Val Ile Met Gly Ala Pro
 1               5                  10                  15      
Gly Ser Gly Lys Gly Thr Val Ser Ser Arg Ile Thr Thr His Phe Glu
            20                  25                  30          
Leu Lys His Leu Ser Ser Gly Asp Leu Leu Arg Asp Asn Met Leu Arg
        35                  40                  45              
Gly Thr Glu Ile Gly Val Leu Ala Lys Ala Phe Ile Asp Gln Gly Lys
    50                  55                  60                  
Leu Ile Pro Asp Asp Val Met Thr Arg Leu Ala Leu His Glu Leu Lys
65                  70                  75                  80  
Asn Leu Thr Gln Tyr Ser Trp Leu Leu Asp Gly Phe Pro Arg Thr Leu
                85                  90                  95      
Pro Gln Ala Glu Ala Leu Asp Arg Ala Tyr Gln Ile Asp Thr Val Ile
            100                 105                 110         
Asn Leu Asn Val Pro Phe Glu Val Ile Lys Gln Arg Leu Thr Ala Arg
        115                 120                 125             
Trp Ile His Pro Ala Ser Gly Arg Val Tyr Asn Ile Glu Phe Asn Pro
    130                 135                 140                 
Pro Lys Thr Val Gly Ile Asp Asp Leu Thr Gly Glu Pro Leu Ile Gln
145                 150                 155                 160 
Arg Glu Asp Asp Lys Pro Glu Thr Val Ile Lys Arg Leu Lys Ala Tyr
                165                 170                 175     
Glu Asp Gln Thr Lys Pro Val Leu Glu Tyr Tyr Gln Lys Lys Gly Val
            180                 185                 190         
Leu Glu Thr Phe Ser Gly Thr Glu Thr Asn Lys Ile Trp Pro Tyr Val
        195                 200                 205             
Tyr Ala Phe Leu Gln Thr Lys Val Pro Gln Arg Ser Gln Lys Ala Ser
    210                 215                 220                 
Val Thr Pro
225         


<210> 1415
<211> 335
<212> PRT
<213> Homo sapiens

<400> 1415
Met Ala Ala Gly Ala Ala Glu Ala Ala Val Ala Ala Val Glu Glu Val
 1               5                  10                  15      
Gly Ser Ala Gly Gln Phe Glu Glu Leu Leu Arg Leu Lys Ala Lys Ser
            20                  25                  30          
Leu Leu Val Val His Phe Trp Ala Pro Trp Ala Pro Gln Cys Ala Gln
        35                  40                  45              
Met Asn Glu Val Met Ala Glu Leu Ala Lys Glu Leu Pro Gln Val Ser
    50                  55                  60                  
Phe Val Lys Leu Glu Ala Glu Gly Val Pro Glu Val Ser Glu Lys Tyr
65                  70                  75                  80  
Glu Ile Ser Ser Val Pro Thr Phe Leu Phe Phe Lys Asn Ser Gln Lys
                85                  90                  95      
Ile Asp Arg Leu Asp Gly Ala His Ala Pro Glu Leu Thr Lys Lys Val
            100                 105                 110         
Gln Arg His Ala Ser Ser Gly Ser Phe Leu Pro Ser Ala Asn Glu His
        115                 120                 125             
Leu Lys Glu Asp Leu Asn Leu Arg Leu Lys Lys Leu Thr His Ala Ala
    130                 135                 140                 
Pro Cys Met Leu Phe Met Lys Gly Thr Pro Gln Glu Pro Arg Cys Gly
145                 150                 155                 160 
Phe Ser Lys Gln Met Val Glu Ile Leu His Lys His Asn Ile Gln Phe
                165                 170                 175     
Ser Ser Phe Asp Ile Phe Ser Asp Glu Glu Val Arg Gln Gly Leu Lys
            180                 185                 190         
Ala Tyr Ser Ser Trp Pro Thr Tyr Pro Gln Leu Tyr Val Ser Gly Glu
        195                 200                 205             
Leu Ile Gly Gly Leu Asp Ile Ile Lys Glu Leu Glu Ala Ser Glu Glu
    210                 215                 220                 
Leu Asp Thr Ile Cys Pro Lys Ala Pro Lys Leu Glu Glu Arg Leu Lys
225                 230                 235                 240 
Val Leu Thr Asn Lys Ala Ser Val Met Leu Phe Met Lys Gly Asn Lys
                245                 250                 255     
Gln Glu Ala Lys Cys Gly Phe Ser Lys Gln Ile Leu Glu Ile Leu Asn
            260                 265                 270         
Ser Thr Gly Val Glu Tyr Glu Thr Phe Asp Ile Leu Glu Asp Glu Glu
        275                 280                 285             
Val Arg Gln Gly Leu Lys Ala Tyr Ser Asn Trp Pro Thr Tyr Pro Gln
    290                 295                 300                 
Leu Tyr Val Lys Gly Glu Leu Val Gly Gly Leu Asp Ile Val Lys Glu
305                 310                 315                 320 
Leu Lys Glu Asn Gly Glu Leu Leu Pro Ile Leu Arg Gly Glu Asn
                325                 330                 335 


<210> 1416
<211> 1012
<212> PRT
<213> Homo sapiens

<400> 1416
Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser
 1               5                  10                  15      
Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg
            20                  25                  30          
Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro
        35                  40                  45              
Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly
    50                  55                  60                  
Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp
65                  70                  75                  80  
Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His
                85                  90                  95      
Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly
            100                 105                 110         
Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser
        115                 120                 125             
Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val
    130                 135                 140                 
Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly
145                 150                 155                 160 
Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu
                165                 170                 175     
Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr
            180                 185                 190         
His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala
        195                 200                 205             
Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe
    210                 215                 220                 
Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro
225                 230                 235                 240 
Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly
                245                 250                 255     
Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu
            260                 265                 270         
Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro
        275                 280                 285             
Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn
    290                 295                 300                 
Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu
305                 310                 315                 320 
Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp
                325                 330                 335     
Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe
            340                 345                 350         
Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala
        355                 360                 365             
Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met
    370                 375                 380                 
Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp
385                 390                 395                 400 
Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly
                405                 410                 415     
Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr
            420                 425                 430         
Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp
        435                 440                 445             
Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe
    450                 455                 460                 
Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp
465                 470                 475                 480 
Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe
                485                 490                 495     
Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn
            500                 505                 510         
Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val
        515                 520                 525             
Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu
    530                 535                 540                 
Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val
545                 550                 555                 560 
Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala
                565                 570                 575     
Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His
            580                 585                 590         
Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln
        595                 600                 605             
Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser
    610                 615                 620                 
Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro
625                 630                 635                 640 
Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala
                645                 650                 655     
Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu
            660                 665                 670         
Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn
        675                 680                 685             
Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu
    690                 695                 700                 
Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His
705                 710                 715                 720 
Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu
                725                 730                 735     
Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val
            740                 745                 750         
Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly
        755                 760                 765             
Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe
    770                 775                 780                 
Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr
785                 790                 795                 800 
Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser
                805                 810                 815     
Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu
            820                 825                 830         
Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val
        835                 840                 845             
Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly
    850                 855                 860                 
Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His
865                 870                 875                 880 
Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn
                885                 890                 895     
Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr
            900                 905                 910         
Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr
        915                 920                 925             
Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr
    930                 935                 940                 
Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu
945                 950                 955                 960 
Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe
                965                 970                 975     
His Thr Arg Lys Ser Leu Leu Ala Phe Ile Ala Phe Leu Phe Phe Ala
            980                 985                 990         
Ser Ile Ile Ser Leu Ser Leu Ile Phe Tyr Tyr Ser Lys Lys Gly Arg
        995                 1000                1005            
Arg Ser Tyr Lys
    1010        


<210> 1417
<211> 441
<212> PRT
<213> Homo sapiens

<400> 1417
Met Leu Gln Cys Pro Ser Val Glu Val Ser Phe Leu Pro Leu Ile Val
 1               5                  10                  15      
Asn Thr Val Ala Leu Pro Asp Glu Leu Ser Tyr Ile Cys Thr His Gly
            20                  25                  30          
Glu Asp Trp Asp Val Ala Tyr Ile Ile His Leu Tyr Pro Ser Leu Thr
        35                  40                  45              
Leu Arg Asn Leu Leu Pro Tyr Ser Leu Arg Tyr Leu Leu Glu Gly Thr
    50                  55                  60                  
Ala Glu Thr His Glu Leu Ala Glu Gly Ser Thr Ala Asp Val Leu His
65                  70                  75                  80  
Ser Arg Ile Ser Gly Glu Ile Met Glu Leu Val Leu Val Lys Tyr Gln
                85                  90                  95      
Gly Lys Asn Trp Asn Gly His Phe Arg Ile Arg Asp Thr Leu Pro Glu
            100                 105                 110         
Phe Phe Pro Val Cys Phe Ser Ser Asp Ser Thr Glu Val Thr Thr Val
        115                 120                 125             
Asp Leu Ser Val His Val Arg Arg Ile Gly Ser Arg Met Val Leu Ser
    130                 135                 140                 
Val Phe Ser Pro Tyr Trp Leu Ile Asn Lys Thr Thr Arg Val Leu Gln
145                 150                 155                 160 
Tyr Arg Ser Glu Asp Ile His Val Lys His Pro Ala Asp Phe Arg Asp
                165                 170                 175     
Ile Ile Leu Phe Ser Phe Lys Lys Lys Asn Ile Phe Thr Lys Asn Lys
            180                 185                 190         
Val Gln Leu Lys Ile Ser Thr Ser Ala Trp Ser Ser Ser Phe Ser Leu
        195                 200                 205             
Asp Thr Val Gly Ser Tyr Gly Cys Val Lys Cys Pro Ala Asn Asn Met
    210                 215                 220                 
Glu Tyr Leu Val Gly Val Ser Ile Lys Met Ser Ser Phe Asn Leu Ser
225                 230                 235                 240 
Arg Ile Val Thr Leu Thr Pro Phe Cys Thr Ile Ala Asn Lys Ser Ser
                245                 250                 255     
Leu Glu Leu Glu Val Gly Glu Ile Ala Ser Asp Gly Ser Met Pro Thr
            260                 265                 270         
Asn Lys Trp Asn Tyr Ile Ala Ser Ser Glu Cys Leu Pro Phe Trp Pro
        275                 280                 285             
Glu Ser Leu Ser Gly Lys Leu Cys Val Arg Val Val Gly Cys Glu Gly
    290                 295                 300                 
Ser Ser Lys Pro Phe Phe Tyr Asn Arg Gln Asp Asn Gly Thr Leu Leu
305                 310                 315                 320 
Ser Leu Glu Asp Leu Asn Gly Gly Ile Leu Val Asp Val Asn Thr Ala
                325                 330                 335     
Glu His Ser Thr Val Ile Thr Phe Ser Asp Tyr His Glu Gly Ser Ala
            340                 345                 350         
Pro Ala Leu Ile Met Asn His Thr Pro Trp Asp Ile Leu Thr Tyr Lys
        355                 360                 365             
Gln Ser Gly Ser Pro Glu Glu Met Val Leu Leu Pro Arg Gln Ala Arg
    370                 375                 380                 
Leu Phe Ala Trp Ala Asp Pro Thr Gly Thr Arg Lys Leu Thr Trp Thr
385                 390                 395                 400 
Tyr Ala Ala Asn Val Gly Glu His Asp Leu Leu Lys Val Ser Phe Asp
                405                 410                 415     
Val Asn Glu Cys Tyr Met Ser Tyr Leu Thr Val Lys Glu Val Glu Lys
            420                 425                 430         
Leu Ser Ser Leu Thr Pro Cys Pro Asn
        435                 440     


<210> 1418
<211> 662
<212> PRT
<213> Homo sapiens

<400> 1418
Met Arg Gly Ala Gly Pro Ser Pro Arg Gln Ser Pro Arg Thr Leu Arg
 1               5                  10                  15      
Pro Asp Pro Gly Pro Ala Met Ser Phe Phe Arg Arg Lys Val Lys Gly
            20                  25                  30          
Lys Glu Gln Glu Lys Thr Ser Asp Val Lys Ser Ile Lys Ala Ser Ile
        35                  40                  45              
Ser Val His Ser Pro Gln Lys Ser Thr Lys Asn His Ala Leu Leu Glu
    50                  55                  60                  
Ala Ala Gly Pro Ser His Val Ala Ile Asn Ala Ile Ser Ala Asn Met
65                  70                  75                  80  
Asp Ser Phe Ser Ser Ser Arg Thr Ala Thr Leu Lys Lys Gln Pro Ser
                85                  90                  95      
His Met Glu Ala Ala His Phe Gly Asp Leu Gly Arg Ser Cys Leu Asp
            100                 105                 110         
Tyr Gln Thr Gln Glu Thr Lys Ser Ser Leu Ser Lys Thr Leu Glu Gln
        115                 120                 125             
Val Leu His Asp Thr Ile Val Leu Pro Tyr Phe Ile Gln Phe Met Glu
    130                 135                 140                 
Leu Arg Arg Met Glu His Leu Val Lys Phe Trp Leu Glu Ala Glu Ser
145                 150                 155                 160 
Phe His Ser Thr Thr Trp Ser Arg Ile Arg Ala His Ser Leu Asn Thr
                165                 170                 175     
Val Lys Gln Ser Ser Leu Ala Glu Pro Val Ser Pro Ser Lys Lys His
            180                 185                 190         
Glu Thr Thr Ala Ser Phe Leu Thr Asp Ser Leu Asp Lys Arg Leu Glu
        195                 200                 205             
Asp Ser Gly Ser Ala Gln Leu Phe Met Thr His Ser Glu Gly Ile Asp
    210                 215                 220                 
Leu Asn Asn Arg Thr Asn Ser Thr Gln Asn His Leu Leu Leu Ser Gln
225                 230                 235                 240 
Glu Cys Asp Ser Ala His Ser Leu Arg Leu Glu Met Ala Arg Ala Gly
                245                 250                 255     
Thr His Gln Val Ser Met Glu Thr Gln Glu Ser Ser Ser Thr Leu Thr
            260                 265                 270         
Val Ala Ser Arg Asn Ser Pro Ala Ser Pro Leu Lys Glu Leu Ser Gly
        275                 280                 285             
Lys Leu Met Lys Ser Ile Glu Gln Asp Ala Val Asn Thr Phe Thr Lys
    290                 295                 300                 
Tyr Ile Ser Pro Asp Ala Ala Lys Pro Ile Pro Ile Thr Glu Ala Met
305                 310                 315                 320 
Arg Asn Asp Ile Ile Ala Arg Ile Cys Gly Glu Asp Gly Gln Val Asp
                325                 330                 335     
Pro Asn Cys Phe Val Leu Ala Gln Ser Ile Val Phe Ser Ala Met Glu
            340                 345                 350         
Gln Glu His Phe Ser Glu Phe Leu Arg Ser His His Phe Cys Lys Tyr
        355                 360                 365             
Gln Ile Glu Val Leu Thr Ser Gly Thr Val Tyr Leu Ala Asp Ile Leu
    370                 375                 380                 
Phe Cys Glu Ser Ala Leu Phe Tyr Phe Ser Glu Tyr Met Glu Lys Glu
385                 390                 395                 400 
Asp Ala Val Asn Ile Leu Gln Phe Trp Leu Ala Ala Asp Asn Phe Gln
                405                 410                 415     
Ser Gln Leu Ala Ala Lys Lys Gly Gln Tyr Asp Gly Gln Glu Ala Gln
            420                 425                 430         
Asn Asp Ala Met Ile Leu Tyr Asp Lys Tyr Phe Ser Leu Gln Ala Thr
        435                 440                 445             
His Pro Leu Gly Phe Asp Asp Val Val Arg Leu Glu Ile Glu Ser Asn
    450                 455                 460                 
Ile Cys Arg Glu Gly Gly Pro Leu Pro Asn Cys Phe Thr Thr Pro Leu
465                 470                 475                 480 
Arg Gln Ala Trp Thr Thr Met Glu Lys Val Phe Leu Pro Gly Phe Leu
                485                 490                 495     
Ser Ser Asn Leu Tyr Tyr Lys Tyr Leu Asn Asp Leu Ile His Ser Val
            500                 505                 510         
Arg Gly Asp Glu Phe Leu Gly Gly Asn Val Ser Leu Thr Ala Pro Gly
        515                 520                 525             
Ser Val Gly Pro Pro Asp Glu Ser His Pro Gly Ser Ser Asp Ser Ser
    530                 535                 540                 
Ala Ser Gln Ser Ser Val Lys Lys Ala Ser Ile Lys Ile Leu Lys Asn
545                 550                 555                 560 
Phe Asp Glu Ala Ile Ile Val Asp Ala Ala Ser Leu Asp Pro Glu Ser
                565                 570                 575     
Leu Tyr Gln Arg Thr Tyr Ala Gly Lys Met Thr Phe Gly Arg Val Ser
            580                 585                 590         
Asp Leu Gly Gln Phe Ile Arg Glu Ser Glu Pro Glu Pro Asp Val Arg
        595                 600                 605             
Lys Ser Lys Gly Ser Met Phe Ser Gln Ala Met Lys Lys Trp Val Gln
    610                 615                 620                 
Gly Asn Thr Asp Glu Ala Gln Glu Glu Leu Ala Trp Lys Ile Ala Lys
625                 630                 635                 640 
Met Ile Val Ser Asp Ile Met Gln Gln Ala Gln Tyr Asp Gln Pro Leu
                645                 650                 655     
Glu Lys Ser Thr Lys Leu
            660         


<210> 1419
<211> 382
<212> PRT
<213> Homo sapiens

<400> 1419
Met Ser Val Leu Arg Arg Met Met Arg Val Ser Asn Arg Ser Leu Leu
 1               5                  10                  15      
Ala Phe Ile Phe Phe Phe Ser Leu Ser Ser Ser Cys Leu Tyr Phe Ile
            20                  25                  30          
Tyr Val Ala Pro Gly Ile Ala Asn Thr Tyr Leu Phe Met Val Gln Ala
        35                  40                  45              
Arg Gly Ile Met Leu Arg Glu Asn Val Lys Thr Ile Gly His Met Ile
    50                  55                  60                  
Arg Leu Tyr Thr Asn Lys Asn Ser Thr Leu Asn Gly Thr Asp Tyr Pro
65                  70                  75                  80  
Glu Gly Asn Asn Ser Ser Asp Tyr Leu Val Gln Thr Thr Thr Tyr Leu
                85                  90                  95      
Pro Glu Asn Phe Thr Tyr Ser Pro Tyr Leu Pro Cys Pro Glu Lys Leu
            100                 105                 110         
Pro Tyr Met Arg Gly Phe Leu Asn Val Asn Val Ser Glu Val Ser Phe
        115                 120                 125             
Asp Glu Ile His Gln Leu Phe Ser Lys Asp Leu Asp Ile Glu Pro Gly
    130                 135                 140                 
Gly His Trp Arg Pro Lys Asp Cys Lys Pro Arg Trp Lys Val Ala Val
145                 150                 155                 160 
Leu Ile Pro Phe Arg Asn Arg His Glu His Leu Pro Ile Phe Phe Leu
                165                 170                 175     
His Leu Ile Pro Met Leu Gln Lys Gln Arg Leu Glu Phe Ala Phe Tyr
            180                 185                 190         
Val Ile Glu Gln Thr Gly Thr Gln Pro Phe Asn Arg Ala Met Leu Phe
        195                 200                 205             
Asn Val Gly Phe Lys Glu Ala Met Lys Asp Ser Val Trp Asp Cys Val
    210                 215                 220                 
Ile Phe His Asp Val Asp His Leu Pro Glu Asn Asp Arg Asn Tyr Tyr
225                 230                 235                 240 
Gly Cys Gly Glu Met Pro Arg His Phe Ala Ala Lys Leu Asp Lys Tyr
                245                 250                 255     
Met Tyr Ile Leu Pro Tyr Lys Glu Phe Phe Gly Gly Val Ser Gly Leu
            260                 265                 270         
Thr Val Glu Gln Phe Arg Lys Ile Asn Gly Phe Pro Asn Ala Phe Trp
        275                 280                 285             
Gly Trp Gly Gly Glu Asp Asp Asp Leu Trp Asn Arg Val His Tyr Ala
    290                 295                 300                 
Gly Tyr Asn Val Thr Arg Pro Glu Gly Asp Leu Gly Lys Tyr Lys Ser
305                 310                 315                 320 
Ile Pro His His His Arg Gly Glu Val Gln Phe Leu Gly Arg Tyr Lys
                325                 330                 335     
Leu Leu Arg Tyr Ser Lys Glu Arg Gln Tyr Ile Asp Gly Leu Asn Asn
            340                 345                 350         
Leu Ile Tyr Arg Pro Lys Ile Leu Val Asp Arg Leu Tyr Thr Asn Ile
        355                 360                 365             
Ser Val Asn Leu Met Pro Glu Leu Ala Pro Ile Glu Asp Tyr
    370                 375                 380         


<210> 1420
<211> 227
<212> PRT
<213> Homo sapiens

<400> 1420
Met Phe Glu Pro Val Ser Cys Thr Phe Thr Tyr Leu Leu Gly Asp Arg
 1               5                  10                  15      
Glu Ser Arg Glu Ala Val Leu Ile Asp Pro Val Leu Glu Thr Ala Pro
            20                  25                  30          
Arg Asp Ala Gln Leu Ile Lys Glu Leu Gly Leu Arg Leu Leu Tyr Ala
        35                  40                  45              
Val Asn Thr His Cys His Ala Asp His Ile Thr Gly Ser Gly Leu Leu
    50                  55                  60                  
Arg Ser Leu Leu Pro Gly Cys Gln Ser Val Ile Ser Arg Leu Ser Gly
65                  70                  75                  80  
Ala Gln Ala Asp Leu His Ile Glu Asp Gly Asp Ser Ile Arg Phe Gly
                85                  90                  95      
Arg Phe Ala Leu Glu Thr Arg Ala Ser Pro Gly His Thr Pro Gly Cys
            100                 105                 110         
Val Thr Phe Val Leu Asn Asp His Ser Met Ala Phe Thr Gly Asp Ala
        115                 120                 125             
Leu Leu Ile Arg Gly Cys Gly Arg Thr Asp Phe Gln Gln Gly Cys Ala
    130                 135                 140                 
Lys Thr Leu Tyr His Ser Val His Glu Lys Ile Phe Thr Leu Pro Gly
145                 150                 155                 160 
Asp Cys Leu Ile Tyr Pro Ala His Asp Tyr His Gly Phe Thr Val Ser
                165                 170                 175     
Thr Val Glu Glu Glu Arg Thr Leu Asn Pro Arg Leu Thr Leu Ser Cys
            180                 185                 190         
Glu Glu Phe Val Lys Ile Met Gly Asn Leu Asn Leu Pro Lys Pro Gln
        195                 200                 205             
Gln Ile Asp Phe Ala Val Pro Ala Asn Met Arg Cys Gly Val Gln Thr
    210                 215                 220                 
Pro Thr Ala
225         


<210> 1421
<211> 1321
<212> PRT
<213> Homo sapiens

<400> 1421
Met Gly Ala Pro Phe Val Trp Ala Leu Gly Leu Leu Met Leu Gln Met
 1               5                  10                  15      
Leu Leu Phe Val Ala Gly Glu Gln Gly Thr Gln Asp Ile Thr Asp Ala
            20                  25                  30          
Ser Glu Arg Gly Leu His Met Gln Lys Leu Gly Ser Gly Ser Val Gln
        35                  40                  45              
Ala Ala Leu Ala Glu Leu Val Ala Leu Pro Cys Leu Phe Thr Leu Gln
    50                  55                  60                  
Pro Arg Pro Ser Ala Ala Arg Asp Ala Pro Arg Ile Lys Trp Thr Lys
65                  70                  75                  80  
Val Arg Thr Ala Ser Gly Gln Arg Gln Asp Leu Pro Ile Leu Val Ala
                85                  90                  95      
Lys Asp Asn Val Val Arg Val Ala Lys Ser Trp Gln Gly Arg Val Ser
            100                 105                 110         
Leu Pro Ser Tyr Pro Arg Arg Arg Ala Asn Ala Thr Leu Leu Leu Gly
        115                 120                 125             
Pro Leu Arg Ala Ser Asp Ser Gly Leu Tyr Arg Cys Gln Val Val Arg
    130                 135                 140                 
Gly Ile Glu Asp Glu Gln Asp Leu Val Pro Leu Glu Val Thr Gly Val
145                 150                 155                 160 
Val Phe His Tyr Arg Ser Ala Arg Asp Arg Tyr Ala Leu Thr Phe Ala
                165                 170                 175     
Glu Ala Gln Glu Ala Cys Arg Leu Ser Ser Ala Ile Ile Ala Ala Pro
            180                 185                 190         
Arg His Leu Gln Ala Ala Phe Glu Asp Gly Phe Asp Asn Cys Asp Ala
        195                 200                 205             
Gly Trp Leu Ser Asp Arg Thr Val Arg Tyr Pro Ile Thr Gln Ser Arg
    210                 215                 220                 
Pro Gly Cys Tyr Gly Asp Arg Ser Ser Leu Pro Gly Val Arg Ser Tyr
225                 230                 235                 240 
Gly Arg Arg Asn Pro Gln Glu Leu Tyr Asp Val Tyr Cys Phe Ala Arg
                245                 250                 255     
Glu Leu Gly Gly Glu Val Phe Tyr Val Gly Pro Ala Arg Arg Leu Thr
            260                 265                 270         
Leu Ala Gly Ala Arg Ala Gln Cys Arg Arg Gln Gly Ala Ala Leu Ala
        275                 280                 285             
Ser Val Gly Gln Leu His Leu Ala Trp His Glu Gly Leu Asp Gln Cys
    290                 295                 300                 
Asp Pro Gly Trp Leu Ala Asp Gly Ser Val Arg Tyr Pro Ile Gln Thr
305                 310                 315                 320 
Pro Arg Arg Arg Cys Gly Gly Pro Ala Pro Gly Val Arg Thr Val Tyr
                325                 330                 335     
Arg Phe Ala Asn Arg Thr Gly Phe Pro Ser Pro Ala Glu Arg Phe Asp
            340                 345                 350         
Ala Tyr Cys Phe Arg Ala His His Pro Thr Ser Gln His Gly Asp Leu
        355                 360                 365             
Glu Thr Pro Ser Ser Gly Asp Glu Gly Glu Ile Leu Ser Ala Glu Gly
    370                 375                 380                 
Pro Pro Val Arg Glu Leu Glu Pro Thr Leu Glu Glu Glu Glu Val Val
385                 390                 395                 400 
Thr Pro Asp Phe Gln Glu Pro Leu Val Ser Ser Gly Glu Glu Glu Thr
                405                 410                 415     
Leu Ile Leu Glu Glu Lys Gln Glu Ser Gln Gln Thr Leu Ser Pro Thr
            420                 425                 430         
Pro Gly Asp Pro Met Leu Ala Ser Trp Pro Thr Gly Glu Val Trp Leu
        435                 440                 445             
Ser Thr Val Ala Pro Ser Pro Ser Asp Met Gly Ala Gly Thr Ala Ala
    450                 455                 460                 
Ser Ser His Thr Glu Val Ala Pro Thr Asp Pro Met Pro Arg Arg Arg
465                 470                 475                 480 
Gly Arg Phe Lys Gly Leu Asn Gly Arg Tyr Phe Gln Gln Gln Glu Pro
                485                 490                 495     
Glu Pro Gly Leu Gln Gly Gly Met Glu Ala Ser Ala Gln Pro Pro Thr
            500                 505                 510         
Ser Glu Ala Ala Val Asn Gln Met Glu Pro Pro Leu Ala Met Ala Val
        515                 520                 525             
Thr Glu Met Leu Gly Ser Gly Gln Ser Arg Ser Pro Trp Ala Asp Leu
    530                 535                 540                 
Thr Asn Glu Val Asp Met Pro Gly Ala Gly Ser Ala Gly Gly Lys Ser
545                 550                 555                 560 
Ser Pro Glu Pro Trp Leu Trp Pro Pro Thr Met Val Pro Pro Ser Ile
                565                 570                 575     
Ser Gly His Ser Arg Ala Pro Val Leu Glu Leu Glu Lys Ala Glu Gly
            580                 585                 590         
Pro Ser Ala Arg Pro Ala Thr Pro Asp Leu Phe Trp Ser Pro Leu Glu
        595                 600                 605             
Ala Thr Val Ser Ala Pro Ser Pro Ala Pro Trp Glu Ala Phe Pro Val
    610                 615                 620                 
Ala Thr Ser Pro Asp Leu Pro Met Met Ala Met Leu Arg Gly Pro Lys
625                 630                 635                 640 
Glu Trp Met Leu Pro His Pro Thr Pro Ile Ser Thr Glu Ala Asn Arg
                645                 650                 655     
Val Glu Ala His Gly Glu Ala Thr Ala Thr Ala Pro Pro Ser Pro Ala
            660                 665                 670         
Ala Glu Thr Lys Val Tyr Ser Leu Pro Leu Ser Leu Thr Pro Thr Gly
        675                 680                 685             
Gln Gly Gly Glu Ala Met Pro Thr Thr Pro Glu Ser Pro Arg Ala Asp
    690                 695                 700                 
Phe Arg Glu Thr Gly Glu Thr Ser Pro Ala Gln Val Asn Lys Ala Glu
705                 710                 715                 720 
His Ser Ser Ser Ser Pro Trp Pro Ser Val Asn Arg Asn Val Ala Val
                725                 730                 735     
Gly Phe Val Pro Thr Glu Thr Ala Thr Glu Pro Thr Gly Leu Arg Gly
            740                 745                 750         
Ile Pro Gly Ser Glu Ser Gly Val Phe Asp Thr Ala Glu Ser Pro Thr
        755                 760                 765             
Ser Gly Leu Gln Ala Thr Val Asp Glu Val Gln Asp Pro Trp Pro Ser
    770                 775                 780                 
Val Tyr Ser Lys Gly Leu Asp Ala Ser Ser Pro Ser Ala Pro Leu Gly
785                 790                 795                 800 
Ser Pro Gly Val Phe Leu Val Pro Lys Val Thr Pro Asn Leu Glu Pro
                805                 810                 815     
Trp Val Ala Thr Asp Glu Gly Pro Thr Val Asn Pro Met Asp Ser Thr
            820                 825                 830         
Val Thr Pro Ala Pro Ser Asp Ala Ser Gly Ile Trp Glu Pro Gly Ser
        835                 840                 845             
Gln Val Phe Glu Glu Ala Glu Ser Thr Thr Leu Ser Pro Gln Val Ala
    850                 855                 860                 
Leu Asp Thr Ser Ile Val Thr Pro Leu Thr Thr Leu Glu Gln Gly Asp
865                 870                 875                 880 
Lys Val Gly Val Pro Ala Met Ser Thr Leu Gly Ser Ser Ser Ser Gln
                885                 890                 895     
Pro His Pro Glu Pro Glu Asp Gln Val Glu Thr Gln Gly Thr Ser Gly
            900                 905                 910         
Ala Ser Val Pro Pro His Gln Ser Ser Pro Leu Gly Lys Pro Ala Val
        915                 920                 925             
Pro Pro Gly Thr Pro Thr Ala Ala Ser Val Gly Glu Ser Ala Ser Val
    930                 935                 940                 
Ser Ser Gly Glu Pro Thr Val Pro Trp Asp Pro Ser Ser Thr Leu Leu
945                 950                 955                 960 
Pro Val Thr Leu Gly Ile Glu Asp Phe Glu Leu Glu Val Leu Ala Gly
                965                 970                 975     
Ser Pro Gly Val Glu Ser Phe Trp Glu Glu Val Ala Ser Gly Glu Glu
            980                 985                 990         
Pro Ala Leu Pro Gly Thr Pro Met Asn Ala Gly Ala Glu Glu Val His
        995                 1000                1005            
Ser Asp Pro Cys Glu Asn Asn Pro Cys Leu His Gly Gly Thr Cys Asn
    1010                1015                1020                
Ala Asn Gly Thr Met Tyr Gly Cys Ser Cys Asp Gln Gly Phe Ala Gly
1025                1030                1035                1040
Glu Asn Cys Glu Ile Asp Ile Asp Asp Cys Leu Cys Ser Pro Cys Glu
                1045                1050                1055    
Asn Gly Gly Thr Cys Ile Asp Glu Val Asn Gly Phe Val Cys Leu Cys
            1060                1065                1070        
Leu Pro Ser Tyr Gly Gly Ser Phe Cys Glu Lys Asp Thr Glu Gly Cys
        1075                1080                1085            
Asp Arg Gly Trp His Lys Phe Gln Gly His Cys Tyr Arg Tyr Phe Ala
    1090                1095                1100                
His Arg Arg Ala Trp Glu Asp Ala Glu Lys Asp Cys Arg Arg Arg Ser
1105                1110                1115                1120
Gly His Leu Thr Ser Val His Ser Pro Glu Glu His Ser Phe Ile Asn
                1125                1130                1135    
Ser Phe Gly His Glu Asn Thr Trp Ile Gly Leu Asn Asp Arg Ile Val
            1140                1145                1150        
Glu Arg Asp Phe Gln Trp Thr Asp Asn Thr Gly Leu Gln Phe Glu Asn
        1155                1160                1165            
Trp Arg Glu Asn Gln Pro Asp Asn Phe Phe Ala Gly Gly Glu Asp Cys
    1170                1175                1180                
Val Val Met Val Ala His Glu Ser Gly Arg Trp Asn Asp Val Pro Cys
1185                1190                1195                1200
Asn Tyr Asn Leu Pro Tyr Val Cys Lys Lys Gly Thr Val Leu Cys Gly
                1205                1210                1215    
Pro Pro Pro Ala Val Glu Asn Ala Ser Leu Ile Gly Ala Arg Lys Ala
            1220                1225                1230        
Lys Tyr Asn Val His Ala Thr Val Arg Tyr Gln Cys Asn Glu Gly Phe
        1235                1240                1245            
Ala Gln His His Val Ala Thr Ile Arg Cys Arg Ser Asn Gly Lys Trp
    1250                1255                1260                
Asp Arg Pro Gln Ile Val Cys Thr Lys Pro Arg Arg Ser His Arg Met
1265                1270                1275                1280
Arg Arg His His His His His Gln His His His Gln His His His His
                1285                1290                1295    
Lys Ser Arg Lys Glu Arg Arg Lys His Lys Lys His Pro Thr Glu Asp
            1300                1305                1310        
Trp Glu Lys Asp Glu Gly Asn Phe Cys
        1315                1320    


<210> 1422
<211> 652
<212> PRT
<213> Homo sapiens

<400> 1422
Met Ala Thr Ser Met Gly Leu Leu Leu Leu Leu Leu Leu Leu Leu Thr
 1               5                  10                  15      
Gln Pro Gly Ala Gly Thr Gly Ala Asp Thr Glu Ala Val Val Cys Val
            20                  25                  30          
Gly Thr Ala Cys Tyr Thr Ala His Ser Gly Lys Leu Ser Ala Ala Glu
        35                  40                  45              
Ala Gln Asn His Cys Asn Gln Asn Gly Gly Asn Leu Ala Thr Val Lys
    50                  55                  60                  
Ser Lys Glu Glu Ala Gln His Val Gln Arg Val Leu Ala Gln Leu Leu
65                  70                  75                  80  
Arg Arg Glu Ala Ala Leu Thr Ala Arg Met Ser Lys Phe Trp Ile Gly
                85                  90                  95      
Leu Gln Arg Glu Lys Gly Lys Cys Leu Asp Pro Ser Leu Pro Leu Lys
            100                 105                 110         
Gly Phe Ser Trp Val Gly Gly Gly Glu Asp Thr Pro Tyr Ser Asn Trp
        115                 120                 125             
His Lys Glu Leu Arg Asn Ser Cys Ile Ser Lys Arg Cys Val Ser Leu
    130                 135                 140                 
Leu Leu Asp Leu Ser Gln Pro Leu Leu Pro Ser Arg Leu Pro Lys Trp
145                 150                 155                 160 
Ser Glu Gly Pro Cys Gly Ser Pro Gly Ser Pro Gly Ser Asn Ile Glu
                165                 170                 175     
Gly Phe Val Cys Lys Phe Ser Phe Lys Gly Met Cys Arg Pro Leu Ala
            180                 185                 190         
Leu Gly Gly Pro Gly Gln Val Thr Tyr Thr Thr Pro Phe Gln Thr Thr
        195                 200                 205             
Ser Ser Ser Leu Glu Ala Val Pro Phe Ala Ser Ala Ala Asn Val Ala
    210                 215                 220                 
Cys Gly Glu Gly Asp Lys Asp Glu Thr Gln Ser His Tyr Phe Leu Cys
225                 230                 235                 240 
Lys Glu Lys Ala Pro Asp Val Phe Asp Trp Gly Ser Ser Gly Pro Leu
                245                 250                 255     
Cys Val Ser Pro Lys Tyr Gly Cys Asn Phe Asn Asn Gly Gly Cys His
            260                 265                 270         
Gln Asp Cys Phe Glu Gly Gly Asp Gly Ser Phe Leu Cys Gly Cys Arg
        275                 280                 285             
Pro Gly Phe Arg Leu Leu Asp Asp Leu Val Thr Cys Ala Ser Arg Asn
    290                 295                 300                 
Pro Cys Ser Ser Ser Pro Cys Arg Gly Gly Ala Thr Cys Val Leu Gly
305                 310                 315                 320 
Pro His Gly Lys Asn Tyr Thr Cys Arg Cys Pro Gln Gly Tyr Gln Leu
                325                 330                 335     
Asp Ser Ser Gln Leu Asp Cys Val Asp Val Asp Glu Cys Gln Asp Ser
            340                 345                 350         
Pro Cys Ala Gln Glu Cys Val Asn Thr Pro Gly Gly Phe Arg Cys Glu
        355                 360                 365             
Cys Trp Val Gly Tyr Glu Pro Gly Gly Pro Gly Glu Gly Ala Cys Gln
    370                 375                 380                 
Asp Val Asp Glu Cys Ala Leu Gly Arg Ser Pro Cys Ala Gln Gly Cys
385                 390                 395                 400 
Thr Asn Thr Asp Gly Ser Phe His Cys Ser Cys Glu Glu Gly Tyr Val
                405                 410                 415     
Leu Ala Gly Glu Asp Gly Thr Gln Cys Gln Asp Val Asp Glu Cys Val
            420                 425                 430         
Gly Pro Gly Gly Pro Leu Cys Asp Ser Leu Cys Phe Asn Thr Gln Gly
        435                 440                 445             
Ser Phe His Cys Gly Cys Leu Pro Gly Trp Val Leu Ala Pro Asn Gly
    450                 455                 460                 
Val Ser Cys Thr Met Gly Pro Val Ser Leu Gly Pro Pro Ser Gly Pro
465                 470                 475                 480 
Pro Asp Glu Glu Asp Lys Gly Glu Lys Glu Gly Ser Thr Val Pro Arg
                485                 490                 495     
Ala Ala Thr Ala Ser Pro Thr Arg Gly Pro Glu Gly Thr Pro Lys Ala
            500                 505                 510         
Thr Pro Thr Thr Ser Arg Pro Ser Leu Ser Ser Asp Ala Pro Ile Thr
        515                 520                 525             
Ser Ala Pro Leu Lys Met Leu Ala Pro Ser Gly Ser Pro Gly Val Trp
    530                 535                 540                 
Arg Glu Pro Ser Ile His His Ala Thr Ala Ala Ser Gly Pro Gln Glu
545                 550                 555                 560 
Pro Ala Gly Gly Asp Ser Ser Val Ala Thr Gln Asn Asn Asp Gly Thr
                565                 570                 575     
Asp Gly Gln Lys Leu Leu Leu Phe Tyr Ile Leu Gly Thr Val Val Ala
            580                 585                 590         
Ile Leu Leu Leu Leu Ala Leu Ala Leu Gly Leu Leu Val Tyr Arg Lys
        595                 600                 605             
Arg Arg Ala Lys Arg Glu Glu Lys Lys Glu Lys Lys Pro Gln Asn Ala
    610                 615                 620                 
Ala Asp Ser Tyr Ser Trp Val Pro Glu Arg Ala Glu Ser Arg Ala Met
625                 630                 635                 640 
Glu Asn Gln Tyr Ser Pro Thr Pro Gly Thr Asp Cys
                645                 650         


<210> 1423
<211> 153
<212> PRT
<213> Homo sapiens

<400> 1423
Met Arg Glu Tyr Lys Leu Val Val Leu Gly Ser Gly Gly Val Gly Lys
 1               5                  10                  15      
Ser Ala Leu Thr Val Gln Phe Val Gln Gly Ile Phe Val Glu Lys Tyr
            20                  25                  30          
Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Glu Val Asp Ala
        35                  40                  45              
Gln Gln Cys Met Leu Glu Ile Leu Asp Thr Ala Gly Thr Glu Gln Phe
    50                  55                  60                  
Thr Ala Met Arg Asp Leu Tyr Met Lys Asn Gly Gln Gly Phe Ala Leu
65                  70                  75                  80  
Val Tyr Ser Ile Thr Ala Gln Ser Thr Phe Asn Asp Leu Gln Asp Leu
                85                  90                  95      
Arg Glu Gln Ile Leu Arg Val Lys Asp Thr Asp Asp Val Pro Met Ile
            100                 105                 110         
Leu Val Gly Asn Lys Cys Asp Leu Glu Asp Glu Arg Val Val Gly Lys
        115                 120                 125             
Glu Gln Gly Gln Asn Leu Ala Asp Asn Gly Thr Thr Val His Ser Tyr
    130                 135                 140                 
Glu Ser Phe Gly Asn Ser Lys Asn Lys
145                 150             


<210> 1424
<211> 69
<212> PRT
<213> Homo sapiens

<400> 1424
Glu Ala Glu Ala Ala Lys Met Leu Gly Glu Ala Leu Ser Lys Asn Pro
 1               5                  10                  15      
Gly Tyr Ile Lys Leu Arg Lys Ile Arg Ala Ala Gln Asn Ile Ser Lys
            20                  25                  30          
Thr Ile Ala Thr Ser Gln Asn Arg Ile Tyr Leu Thr Ala Asp Asn Leu
        35                  40                  45              
Val Leu Asn Leu Gln Asp Glu Ser Phe Thr Arg Gly Ser Asp Ser Leu
    50                  55                  60                  
Ile Lys Gly Lys Lys
65                  


<210> 1425
<211> 2641
<212> PRT
<213> Homo sapiens

<400> 1425
Met Pro Ile Thr Gln Asp Asn Ala Val Leu His Leu Pro Leu Leu Tyr
 1               5                  10                  15      
Gln Trp Leu Gln Asn Ser Leu Gln Glu Gly Gly Asp Gly Pro Glu Gln
            20                  25                  30          
Arg Leu Cys Gln Ala Ala Ile Gln Lys Leu Gln Glu Tyr Ile Gln Leu
        35                  40                  45              
Asn Phe Ala Val Asp Glu Ser Thr Val Pro Pro Asp His Ser Pro Pro
    50                  55                  60                  
Glu Met Glu Ile Cys Thr Val Tyr Leu Thr Lys Glu Leu Gly Asp Thr
65                  70                  75                  80  
Glu Thr Val Gly Leu Ser Phe Gly Asn Ile Pro Val Phe Gly Asp Tyr
                85                  90                  95      
Gly Glu Lys Arg Arg Gly Gly Lys Lys Arg Lys Thr His Gln Gly Pro
            100                 105                 110         
Val Leu Asp Val Gly Cys Ile Trp Val Thr Glu Leu Arg Lys Asn Ser
        115                 120                 125             
Pro Ala Gly Lys Ser Gly Lys Val Arg Leu Arg Asp Glu Ile Leu Ser
    130                 135                 140                 
Leu Asn Gly Gln Leu Met Val Gly Val Asp Val Ser Gly Ala Ser Tyr
145                 150                 155                 160 
Leu Ala Glu Gln Cys Trp Asn Gly Gly Phe Ile Tyr Leu Ile Met Leu
                165                 170                 175     
Arg Arg Phe Lys His Lys Ala His Ser Thr Tyr Asn Gly Asn Ser Ser
            180                 185                 190         
Asn Ser Ser Glu Pro Gly Glu Thr Pro Thr Leu Glu Leu Gly Asp Arg
        195                 200                 205             
Thr Ala Lys Lys Gly Lys Arg Thr Arg Lys Phe Gly Val Ile Ser Arg
    210                 215                 220                 
Pro Pro Ala Asn Lys Ala Pro Glu Glu Ser Lys Gly Ser Ala Gly Cys
225                 230                 235                 240 
Glu Val Ser Ser Asp Pro Ser Thr Glu Leu Glu Asn Gly Ala Asp Pro
                245                 250                 255     
Glu Leu Gly Asn Gly His Val Phe Gln Leu Glu Asn Gly Pro Asp Ser
            260                 265                 270         
Leu Lys Glu Val Ala Gly Pro His Leu Glu Arg Ser Glu Val Asp Arg
        275                 280                 285             
Gly Thr Glu His Arg Ile Pro Lys Thr Asp Ala Pro Leu Thr Thr Ser
    290                 295                 300                 
Asn Asp Lys Arg Arg Phe Ser Lys Gly Gly Lys Thr Asp Phe Gln Ser
305                 310                 315                 320 
Ser Asp Cys Leu Ala Arg Gln Glu Glu Val Gly Arg Ile Trp Lys Met
                325                 330                 335     
Glu Leu Leu Lys Glu Ser Asp Gly Leu Gly Ile Gln Val Ser Gly Gly
            340                 345                 350         
Arg Gly Ser Lys Arg Ser Pro His Ala Ile Val Val Thr Gln Val Lys
        355                 360                 365             
Glu Gly Gly Ala Ala His Arg Glu Tyr His Ile Val Lys Lys Ser Thr
    370                 375                 380                 
Arg Ser Leu Ser Thr Thr Gln Val Glu Ser Pro Trp Arg Leu Ile Arg
385                 390                 395                 400 
Pro Ser Val Ile Ser Ile Ile Gly Leu Tyr Lys Glu Lys Gly Lys Gly
                405                 410                 415     
Leu Gly Phe Ser Ile Ala Gly Gly Arg Asp Cys Ile Arg Gly Gln Met
            420                 425                 430         
Gly Ile Phe Val Lys Thr Ile Phe Pro Asn Gly Ser Ala Ala Glu Asp
        435                 440                 445             
Gly Arg Leu Lys Glu Gly Asp Glu Ile Leu Asp Val Asn Gly Ile Pro
    450                 455                 460                 
Ile Lys Gly Leu Thr Phe Gln Glu Ala Ile His Thr Phe Lys Gln Ile
465                 470                 475                 480 
Arg Ser Gly Leu Phe Val Leu Thr Val Arg Thr Lys Leu Val Ser Pro
                485                 490                 495     
Ser Leu Thr Pro Cys Ser Thr Pro Thr His Met Ser Arg Ser Ala Ser
            500                 505                 510         
Pro Asn Phe Asn Thr Ser Gly Gly Ala Ser Ala Gly Gly Ser Asp Glu
        515                 520                 525             
Gly Ser Ser Ser Ser Leu Gly Arg Lys Thr Pro Gly Pro Lys Asp Arg
    530                 535                 540                 
Ile Val Met Glu Val Thr Leu Asn Lys Glu Pro Arg Val Gly Leu Gly
545                 550                 555                 560 
Ile Gly Ala Cys Cys Leu Ala Leu Glu Asn Ser Pro Pro Gly Ile Tyr
                565                 570                 575     
Ile His Ser Leu Ala Pro Gly Ser Val Ala Lys Met Glu Ser Asn Leu
            580                 585                 590         
Ser Arg Gly Asp Gln Ile Leu Glu Val Asn Ser Val Asn Val Arg His
        595                 600                 605             
Ala Ala Leu Ser Lys Val His Ala Ile Leu Ser Lys Cys Pro Val Ser
    610                 615                 620                 
Glu Gln Glu Met Asp Glu Val Ile Ala Arg Ser Thr Tyr Gln Glu Ser
625                 630                 635                 640 
Lys Glu Ala Asn Ser Ser Pro Gly Leu Gly Thr Pro Leu Lys Ser Pro
                645                 650                 655     
Ser Leu Ala Lys Lys Asp Ser Leu Ile Ser Glu Ser Glu Leu Ser Gln
            660                 665                 670         
Tyr Phe Ala His Asp Val Pro Gly Pro Leu Ser Asp Phe Met Val Ala
        675                 680                 685             
Gly Ser Glu Asp Glu Asp His Pro Gly Ser Gly Cys Ser Thr Ser Glu
    690                 695                 700                 
Glu Gly Ser Leu Pro Pro Ser Thr Ser Ser Glu Pro Gly Lys Pro Arg
705                 710                 715                 720 
Ala Asn Ser Leu Val Thr Leu Gly Ser His Arg Ala Ser Gly Leu Phe
                725                 730                 735     
His Lys Gln Val Thr Val Ala Arg Gln Ala Ser Leu Pro Gly Ser Pro
            740                 745                 750         
Gln Ala Leu Arg Asn Pro Leu Leu Arg Gln Arg Lys Val Gly Cys Tyr
        755                 760                 765             
Asp Ala Asn Asp Ala Ser Asp Glu Glu Glu Phe Asp Arg Glu Gly Asp
    770                 775                 780                 
Cys Ile Ser Leu Pro Gly Ala Leu Pro Gly Pro Ile Arg Pro Leu Ser
785                 790                 795                 800 
Glu Asp Asp Pro Arg Arg Val Ser Ile Ser Ser Ser Lys Gly Met Asp
                805                 810                 815     
Val His Asn Gln Glu Glu Arg Pro Arg Lys Thr Leu Val Ser Lys Ala
            820                 825                 830         
Ile Ser Ala Pro Leu Leu Gly Ser Ser Val Asp Leu Glu Glu Ser Ile
        835                 840                 845             
Pro Glu Gly Met Val Asp Ala Ala Ser Tyr Ala Ala Asn Leu Thr Asp
    850                 855                 860                 
Ser Ala Glu Ala Pro Lys Gly Ser Pro Gly Ser Trp Trp Lys Lys Glu
865                 870                 875                 880 
Leu Ser Gly Ser Ser Ser Ala Pro Lys Leu Glu Tyr Thr Val Arg Thr
                885                 890                 895     
Asp Thr Gln Ser Pro Thr Asn Thr Gly Ser Pro Ser Ser Pro Gln Gln
            900                 905                 910         
Lys Ser Glu Gly Leu Gly Ser Arg His Arg Pro Val Ala Arg Val Ser
        915                 920                 925             
Pro His Cys Lys Arg Ser Glu Ala Glu Ala Lys Pro Ser Gly Ser Gln
    930                 935                 940                 
Thr Val Asn Leu Thr Gly Arg Ala Asn Asp Pro Cys Asp Leu Asp Ser
945                 950                 955                 960 
Arg Val Gln Ala Thr Ser Val Lys Val Thr Val Ala Gly Phe Gln Pro
                965                 970                 975     
Gly Gly Ala Val Glu Lys Leu Cys Gln Glu Ser Leu Gly Lys Leu Thr
            980                 985                 990         
Thr Gly Asp Ala Cys Val Ser Thr Ser Cys Glu Leu Ala Ser Ala Leu
        995                 1000                1005            
Ser His Leu Asp Ala Ser His Leu Thr Glu Asn Leu Pro Lys Ala Ala
    1010                1015                1020                
Ser Glu Leu Gly Gln Gln Pro Met Thr Ser Ser Asp Leu Ile Ser Ser
1025                1030                1035                1040
Pro Gly Lys Lys Gly Ala Ala His Pro Asp Pro Ser Lys Thr Ser Val
                1045                1050                1055    
Asp Thr Gly Gln Val Ser Arg Pro Glu Asn Pro Ser Gln Pro Ala Ser
            1060                1065                1070        
Pro Arg Val Thr Lys Cys Lys Ala Arg Ser Pro Val Arg Leu Pro His
        1075                1080                1085            
Glu Gly Ser Pro Ser Pro Gly Glu Lys Ala Ala Ala Pro Pro Asp Tyr
    1090                1095                1100                
Ser Lys Thr Arg Ser Ala Ser Glu Thr Ser Thr Pro His Asn Thr Arg
1105                1110                1115                1120
Arg Val Ala Ala Leu Arg Gly Ala Gly Pro Gly Ala Glu Gly Met Thr
                1125                1130                1135    
Pro Ala Gly Ala Val Leu Pro Gly Asp Pro Leu Thr Ser Gln Glu Gln
            1140                1145                1150        
Arg Gln Gly Ala Pro Gly Asn His Ser Lys Ala Leu Glu Met Thr Gly
        1155                1160                1165            
Ile His Ala Pro Glu Ser Ser Gln Glu Pro Ser Leu Leu Glu Gly Ala
    1170                1175                1180                
Asp Ser Val Ser Ser Arg Ala Pro Gln Ala Ser Leu Ser Met Leu Pro
1185                1190                1195                1200
Ser Thr Asp Asn Thr Lys Glu Ala Cys Gly His Val Ser Gly His Cys
                1205                1210                1215    
Cys Pro Gly Gly Ser Arg Glu Ser Pro Val Thr Asp Ile Asp Ser Phe
            1220                1225                1230        
Ile Lys Glu Leu Asp Ala Ser Ala Ala Arg Ser Pro Ser Ser Gln Thr
        1235                1240                1245            
Gly Asp Ser Gly Ser Gln Glu Gly Ser Ala Gln Gly His Pro Pro Ala
    1250                1255                1260                
Gly Ala Gly Gly Gly Ser Ser Cys Arg Ala Glu Pro Val Pro Gly Gly
1265                1270                1275                1280
Gln Thr Ser Ser Pro Arg Arg Ala Trp Ala Ala Gly Ala Pro Ala Tyr
                1285                1290                1295    
Pro Gln Trp Ala Ser Gln Pro Ser Val Leu Asp Ser Ile Asn Pro Asp
            1300                1305                1310        
Lys His Phe Thr Val Asn Lys Asn Phe Leu Ser Asn Tyr Ser Arg Asn
        1315                1320                1325            
Phe Ser Ser Phe His Glu Asp Ser Thr Ser Leu Ser Gly Leu Gly Asp
    1330                1335                1340                
Ser Thr Glu Pro Ser Leu Ser Ser Met Tyr Gly Asp Ala Glu Asp Ser
1345                1350                1355                1360
Ser Ser Asp Pro Glu Ser Leu Thr Glu Ala Pro Arg Ala Ser Ala Arg
                1365                1370                1375    
Asp Gly Trp Ser Pro Pro Arg Ser Arg Val Ser Leu His Lys Glu Asp
            1380                1385                1390        
Pro Ser Glu Ser Glu Glu Glu Gln Ile Glu Ile Cys Ser Thr Arg Gly
        1395                1400                1405            
Cys Pro Asn Pro Pro Ser Ser Pro Ala His Leu Pro Thr Gln Ala Ala
    1410                1415                1420                
Ile Cys Pro Ala Ser Ala Lys Val Leu Ser Leu Lys Tyr Ser Thr Pro
1425                1430                1435                1440
Arg Glu Ser Val Ala Ser Pro Arg Glu Lys Ala Ala Cys Leu Pro Gly
                1445                1450                1455    
Ser Tyr Thr Ser Gly Pro Asp Ser Ser Gln Pro Ser Ser Leu Leu Glu
            1460                1465                1470        
Met Ser Ser Gln Glu His Glu Thr His Ala Asp Ile Ser Thr Ser Gln
        1475                1480                1485            
Asn His Arg Pro Ser Cys Ala Glu Glu Thr Thr Glu Val Thr Ser Ala
    1490                1495                1500                
Ser Ser Ala Met Glu Asn Ser Pro Leu Ser Lys Val Ala Arg His Phe
1505                1510                1515                1520
His Ser Pro Pro Ile Ile Leu Ser Ser Pro Asn Met Val Asn Gly Leu
                1525                1530                1535    
Glu His Asp Leu Leu Asp Asp Glu Thr Leu Asn Gln Tyr Glu Thr Ser
            1540                1545                1550        
Ile Asn Ala Ala Ala Ser Leu Ser Ser Phe Ser Val Asp Val Pro Lys
        1555                1560                1565            
Asn Gly Glu Ser Val Leu Glu Asn Leu His Ile Ser Glu Ser Gln Asp
    1570                1575                1580                
Leu Asp Asp Leu Leu Gln Lys Pro Lys Met Ile Ala Arg Arg Pro Ile
1585                1590                1595                1600
Met Ala Trp Phe Lys Glu Ile Asn Lys His Asn Gln Gly Thr His Leu
                1605                1610                1615    
Arg Ser Lys Thr Glu Lys Glu Gln Pro Leu Met Pro Ala Arg Ser Pro
            1620                1625                1630        
Asp Ser Lys Ile Gln Met Val Ser Ser Ser Gln Lys Lys Gly Val Thr
        1635                1640                1645            
Val Pro His Ser Pro Pro Gln Pro Lys Thr Asn Leu Glu Asn Lys Asp
    1650                1655                1660                
Leu Ser Lys Lys Ser Pro Ala Glu Met Leu Leu Thr Asn Gly Gln Lys
1665                1670                1675                1680
Ala Lys Cys Gly Pro Lys Leu Lys Arg Leu Ser Leu Lys Gly Lys Ala
                1685                1690                1695    
Lys Val Asn Ser Glu Ala Pro Ala Ala Asn Ala Val Lys Ala Gly Gly
            1700                1705                1710        
Thr Asp His Arg Lys Pro Leu Ile Ser Pro Gln Thr Ser His Lys Thr
        1715                1720                1725            
Leu Ser Lys Ala Val Ser Gln Arg Leu His Val Ala Asp His Glu Asp
    1730                1735                1740                
Pro Asp Arg Asn Thr Thr Ala Ala Pro Arg Ser Pro Gln Cys Val Leu
1745                1750                1755                1760
Glu Ser Lys Pro Pro Leu Ala Thr Ser Gly Pro Leu Lys Pro Ser Val
                1765                1770                1775    
Ser Asp Thr Ser Ile Arg Thr Phe Val Ser Pro Leu Thr Ser Pro Lys
            1780                1785                1790        
Pro Val Pro Glu Gln Gly Met Trp Ser Arg Phe His Met Ala Val Leu
        1795                1800                1805            
Ser Glu Pro Asp Arg Gly Cys Pro Thr Thr Pro Lys Ser Pro Lys Cys
    1810                1815                1820                
Arg Ala Glu Gly Arg Ala Pro Arg Ala Asp Ser Gly Pro Val Ser Pro
1825                1830                1835                1840
Ala Ala Ser Arg Asn Gly Met Ser Val Ala Gly Asn Arg Gln Ser Glu
                1845                1850                1855    
Pro Arg Leu Ala Ser His Val Ala Ala Asp Thr Ala Gln Pro Arg Pro
            1860                1865                1870        
Thr Gly Glu Lys Gly Gly Asn Ile Met Ala Ser Asp Arg Leu Glu Arg
        1875                1880                1885            
Thr Asn Gln Leu Lys Ile Val Glu Ile Ser Ala Glu Ala Val Ser Glu
    1890                1895                1900                
Thr Val Cys Gly Asn Lys Pro Ala Glu Ser Asp Arg Arg Gly Gly Cys
1905                1910                1915                1920
Leu Ala Gln Gly Asn Cys Gln Glu Lys Ser Glu Ile Arg Leu Tyr Arg
                1925                1930                1935    
Gln Val Ala Glu Ser Ser Thr Ser His Pro Ser Ser Leu Pro Ser His
            1940                1945                1950        
Ala Ser Gln Ala Glu Gln Glu Met Ser Arg Ser Phe Ser Met Ala Lys
        1955                1960                1965            
Leu Ala Ser Ser Ser Ser Ser Leu Gln Thr Ala Ile Arg Lys Ala Glu
    1970                1975                1980                
Tyr Ser Gln Gly Lys Ser Ser Leu Met Ser Asp Ser Arg Gly Val Pro
1985                1990                1995                2000
Arg Asn Ser Ile Pro Gly Gly Pro Ser Gly Glu Asp His Leu Tyr Phe
                2005                2010                2015    
Thr Pro Arg Pro Ala Thr Arg Thr Tyr Ser Met Pro Ala Gln Phe Ser
            2020                2025                2030        
Ser His Phe Gly Arg Glu Gly His Pro Pro His Ser Leu Gly Arg Ser
        2035                2040                2045            
Arg Asp Ser Gln Val Pro Val Thr Ser Ser Val Val Pro Glu Ala Lys
    2050                2055                2060                
Ala Ser Arg Gly Gly Leu Pro Ser Leu Ala Asn Gly Gln Gly Ile Tyr
2065                2070                2075                2080
Ser Val Lys Pro Leu Leu Asp Thr Ser Arg Asn Leu Pro Ala Thr Asp
                2085                2090                2095    
Glu Gly Asp Ile Ile Ser Val Gln Glu Thr Ser Cys Leu Val Thr Asp
            2100                2105                2110        
Lys Ile Lys Val Thr Arg Arg His Tyr Cys Tyr Glu Gln Asn Trp Pro
        2115                2120                2125            
His Glu Ser Thr Ser Phe Phe Ser Val Lys Gln Arg Ile Lys Ser Phe
    2130                2135                2140                
Glu Asn Leu Ala Asn Ala Asp Arg Pro Val Ala Lys Ser Gly Ala Ser
2145                2150                2155                2160
Pro Phe Leu Ser Val Ser Ser Lys Pro Pro Ile Gly Arg Arg Ser Ser
                2165                2170                2175    
Gly Ser Ile Val Ser Gly Ser Leu Gly His Pro Gly Asp Ala Ala Ala
            2180                2185                2190        
Arg Leu Leu Arg Arg Ser Leu Ser Ser Cys Ser Glu Asn Gln Ser Glu
        2195                2200                2205            
Ala Gly Thr Leu Leu Pro Gln Met Ala Lys Ser Pro Ser Ile Met Thr
    2210                2215                2220                
Leu Thr Ile Ser Arg Gln Asn Pro Pro Glu Thr Ser Ser Lys Gly Ser
2225                2230                2235                2240
Asp Ser Glu Leu Lys Lys Ser Leu Gly Pro Leu Gly Ile Pro Thr Pro
                2245                2250                2255    
Thr Met Thr Leu Ala Ser Pro Val Lys Arg Asn Lys Ser Ser Val Arg
            2260                2265                2270        
His Thr Gln Pro Ser Pro Val Ser Arg Ser Lys Leu Gln Glu Leu Arg
        2275                2280                2285            
Ala Leu Ser Met Pro Asp Leu Asp Lys Leu Cys Ser Glu Asp Tyr Ser
    2290                2295                2300                
Ala Gly Pro Ser Ala Val Leu Phe Lys Thr Glu Leu Glu Ile Thr Pro
2305                2310                2315                2320
Arg Arg Ser Pro Gly Pro Pro Ala Gly Gly Val Ser Cys Pro Glu Lys
                2325                2330                2335    
Gly Gly Asn Arg Ala Cys Pro Gly Gly Ser Gly Pro Lys Thr Ser Ala
            2340                2345                2350        
Ala Glu Thr Pro Ser Ser Ala Ser Asp Thr Gly Glu Ala Ala Gln Asp
        2355                2360                2365            
Leu Pro Phe Arg Arg Ser Trp Ser Val Lys Leu Asp Gln Leu Leu Val
    2370                2375                2380                
Ser Ala Gly Asp Gln Gln Arg Leu Gln Ser Val Leu Ser Ser Val Gly
2385                2390                2395                2400
Ser Lys Ser Thr Ile Leu Thr Leu Ile Gln Glu Ala Lys Ala Gln Ser
                2405                2410                2415    
Glu Asn Glu Glu Asp Val Cys Phe Ile Val Leu Asn Arg Lys Glu Gly
            2420                2425                2430        
Ser Gly Leu Gly Phe Ser Val Ala Gly Gly Thr Asp Val Glu Pro Lys
        2435                2440                2445            
Ser Ile Thr Val His Arg Val Phe Ser Gln Gly Ala Ala Ser Gln Glu
    2450                2455                2460                
Gly Thr Met Asn Arg Gly Asp Phe Leu Leu Ser Val Asn Gly Ala Ser
2465                2470                2475                2480
Leu Ala Gly Leu Ala His Gly Asn Val Leu Lys Val Leu His Gln Ala
                2485                2490                2495    
Gln Leu His Lys Asp Ala Leu Val Val Ile Lys Lys Gly Met Asp Gln
            2500                2505                2510        
Pro Arg Pro Ser Ala Arg Gln Glu Pro Pro Thr Ala Asn Gly Lys Gly
        2515                2520                2525            
Leu Leu Ser Arg Lys Thr Ile Pro Leu Glu Pro Gly Ile Gly Arg Ser
    2530                2535                2540                
Val Ala Val His Asp Ala Leu Cys Val Glu Val Leu Lys Thr Ser Ala
2545                2550                2555                2560
Gly Leu Gly Leu Ser Leu Asp Gly Gly Lys Ser Ser Val Thr Gly Asp
                2565                2570                2575    
Gly Pro Leu Val Ile Lys Arg Val Tyr Lys Gly Gly Ala Ala Glu Gln
            2580                2585                2590        
Ala Gly Ile Ile Glu Ala Gly Asp Glu Ile Leu Ala Ile Asn Gly Lys
        2595                2600                2605            
Pro Leu Val Gly Leu Met His Phe Asp Ala Trp Asn Ile Met Lys Ser
    2610                2615                2620                
Val Pro Glu Gly Pro Val Gln Leu Leu Ile Arg Lys His Arg Asn Ser
2625                2630                2635                2640
Ser
    


<210> 1426
<211> 196
<212> PRT
<213> Homo sapiens

<400> 1426
Gly Thr Arg Pro Arg Ala Ala Gln Ile Leu Ala Ala Glu Ala Gly Leu
 1               5                  10                  15      
Pro Ser Ser Arg Ser Phe Met Gly Phe Ala Ala Pro Phe Thr Asn Lys
            20                  25                  30          
Arg Lys Ala Tyr Ser Glu Arg Arg Ile Met Gly Tyr Ser Met Gln Glu
        35                  40                  45              
Met Tyr Glu Val Val Ser Asn Val Gln Glu Tyr Arg Glu Phe Val Pro
    50                  55                  60                  
Trp Cys Lys Lys Ser Leu Val Val Ser Ser Arg Lys Gly His Leu Lys
65                  70                  75                  80  
Ala Gln Leu Glu Val Gly Phe Pro Pro Val Met Glu Arg Tyr Thr Ser
                85                  90                  95      
Ala Val Ser Met Val Lys Pro His Met Val Lys Ala Val Cys Thr Asp
            100                 105                 110         
Gly Lys Leu Phe Asn His Leu Glu Thr Ile Trp Arg Phe Ser Pro Gly
        115                 120                 125             
Ile Pro Ala Tyr Pro Arg Thr Cys Thr Val Asp Phe Ser Ile Ser Phe
    130                 135                 140                 
Glu Phe Arg Ser Leu Leu His Ser Gln Leu Ala Thr Met Phe Phe Asp
145                 150                 155                 160 
Glu Val Val Lys Gln Asn Val Ala Ala Phe Glu Arg Arg Ala Ala Thr
                165                 170                 175     
Lys Phe Gly Pro Glu Thr Ala Ile Pro Arg Glu Leu Met Phe His Glu
            180                 185                 190         
Val His Gln Thr
        195     


<210> 1427
<211> 284
<212> PRT
<213> Homo sapiens

<400> 1427
Met Cys Asn Thr Pro Thr Tyr Cys Asp Leu Gly Lys Ala Ala Lys Asp
 1               5                  10                  15      
Val Phe Asn Lys Gly Tyr Gly Phe Gly Met Val Lys Ile Asp Leu Lys
            20                  25                  30          
Thr Lys Ser Cys Ser Gly Val Met Glu Phe Ser Thr Ser Gly His Ala
        35                  40                  45              
Tyr Thr Asp Thr Gly Lys Ala Ser Gly Asn Leu Glu Thr Lys Tyr Lys
    50                  55                  60                  
Val Cys Asn Tyr Gly Leu Thr Phe Thr Gln Lys Trp Asn Thr Asp Asn
65                  70                  75                  80  
Thr Leu Gly Thr Glu Ile Ser Trp Glu Asn Lys Leu Ala Glu Gly Leu
                85                  90                  95      
Lys Leu Thr Leu Asp Thr Ile Phe Val Pro Asn Thr Gly Lys Lys Ser
            100                 105                 110         
Gly Lys Leu Lys Ala Ser Tyr Lys Arg Asp Cys Phe Ser Val Gly Ser
        115                 120                 125             
Asn Val Asp Ile Asp Phe Ser Gly Pro Thr Ile Tyr Gly Trp Ala Val
    130                 135                 140                 
Leu Ala Phe Glu Gly Trp Leu Ala Gly Tyr Gln Met Ser Phe Asp Thr
145                 150                 155                 160 
Ala Lys Ser Lys Leu Ser Gln Asn Asn Phe Ala Leu Gly Tyr Lys Ala
                165                 170                 175     
Ala Asp Phe Gln Leu His Thr His Val Asn Asp Gly Thr Glu Phe Gly
            180                 185                 190         
Gly Ser Ile Tyr Gln Lys Val Asn Glu Lys Ile Glu Thr Ser Ile Asn
        195                 200                 205             
Leu Ala Trp Thr Ala Gly Ser Asn Asn Thr Arg Phe Gly Ile Ala Ala
    210                 215                 220                 
Lys Tyr Met Leu Asp Cys Arg Thr Ser Leu Ser Ala Lys Val Asn Asn
225                 230                 235                 240 
Ala Ser Leu Ile Gly Leu Gly Tyr Thr Gln Thr Leu Arg Pro Gly Val
                245                 250                 255     
Lys Leu Thr Leu Ser Ala Leu Ile Asp Gly Lys Asn Phe Ser Ala Gly
            260                 265                 270         
Gly His Lys Val Gly Leu Gly Phe Glu Leu Glu Ala
        275                 280                 


<210> 1428
<211> 345
<212> PRT
<213> Homo sapiens

<400> 1428
Met Leu Pro Cys Phe Gln Leu Leu Arg Ile Gly Gly Gly Arg Gly Gly
 1               5                  10                  15      
Asp Leu Tyr Thr Phe His Pro Pro Ala Gly Ala Gly Cys Thr Tyr Arg
            20                  25                  30          
Leu Gly His Arg Ala Asp Leu Cys Asp Val Ala Leu Arg Pro Gln Gln
        35                  40                  45              
Glu Pro Gly Leu Ile Ser Gly Ile His Ala Glu Leu His Ala Glu Pro
    50                  55                  60                  
Arg Gly Asp Asp Trp Arg Val Ser Leu Glu Asp His Ser Ser Gln Gly
65                  70                  75                  80  
Thr Leu Val Asn Asn Val Arg Leu Pro Arg Gly His Arg Leu Glu Leu
                85                  90                  95      
Ser Asp Gly Asp Leu Leu Thr Phe Gly Pro Glu Gly Pro Pro Gly Thr
            100                 105                 110         
Ser Pro Ser Glu Phe Tyr Phe Met Phe Gln Gln Val Arg Val Lys Pro
        115                 120                 125             
Gln Asp Phe Ala Ala Ile Thr Ile Pro Arg Ser Arg Gly Glu Ala Arg
    130                 135                 140                 
Val Gly Ala Gly Phe Arg Pro Met Leu Pro Ser Gln Gly Ala Pro Gln
145                 150                 155                 160 
Arg Pro Leu Ser Thr Phe Ser Pro Ala Pro Lys Ala Thr Leu Ile Leu
                165                 170                 175     
Asn Ser Ile Gly Ser Leu Ser Lys Leu Arg Pro Gln Pro Leu Thr Phe
            180                 185                 190         
Ser Pro Ser Trp Gly Gly Pro Lys Ser Leu Pro Val Pro Ala Pro Pro
        195                 200                 205             
Gly Glu Val Gly Thr Thr Pro Ser Ala Pro Pro Gln Arg Asn Arg Arg
    210                 215                 220                 
Lys Ser Val His Arg Val Leu Ala Glu Leu Asp Asp Glu Ser Glu Pro
225                 230                 235                 240 
Leu Glu Asn Pro Pro Pro Val Leu Met Glu Pro Arg Lys Lys Leu Arg
                245                 250                 255     
Val Asp Lys Ala Pro Leu Thr Pro Thr Gly Asn Arg Arg Gly Arg Pro
            260                 265                 270         
Arg Lys Tyr Pro Val Ser Ala Pro Met Ala Pro Pro Ala Val Gly Gly
        275                 280                 285             
Gly Glu Pro Cys Ala Ala Pro Cys Cys Cys Leu Pro Gln Glu Glu Thr
    290                 295                 300                 
Val Ala Trp Val Gln Cys Asp Gly Cys Asp Val Trp Phe His Val Ala
305                 310                 315                 320 
Cys Val Gly Cys Ser Ile Gln Ala Ala Arg Glu Ala Asp Phe Arg Cys
                325                 330                 335     
Pro Gly Cys Arg Ala Gly Ile Gln Thr
            340                 345 


<210> 1429
<211> 511
<212> PRT
<213> Homo sapiens

<400> 1429
Met Ser Thr Leu Leu Ile Asn Gln Pro Gln Tyr Ala Trp Leu Lys Glu
 1               5                  10                  15      
Leu Gly Leu Arg Glu Glu Asn Glu Gly Val Tyr Asn Gly Ser Trp Gly
            20                  25                  30          
Gly Arg Gly Glu Val Ile Thr Thr Tyr Cys Pro Ala Asn Asn Glu Pro
        35                  40                  45              
Ile Ala Arg Val Arg Gln Ala Ser Val Ala Asp Tyr Glu Glu Thr Val
    50                  55                  60                  
Lys Lys Ala Arg Glu Ala Trp Lys Ile Trp Ala Asp Ile Pro Ala Pro
65                  70                  75                  80  
Lys Arg Gly Glu Ile Val Arg Gln Ile Gly Asp Ala Leu Arg Glu Lys
                85                  90                  95      
Ile Gln Val Leu Gly Ser Leu Val Ser Leu Glu Met Gly Lys Ile Leu
            100                 105                 110         
Val Glu Gly Val Gly Glu Val Gln Glu Tyr Val Asp Ile Cys Asp Tyr
        115                 120                 125             
Ala Val Gly Leu Ser Arg Met Ile Gly Gly Pro Ile Leu Pro Ser Glu
    130                 135                 140                 
Arg Ser Gly His Ala Leu Ile Glu Gln Trp Asn Pro Val Gly Leu Val
145                 150                 155                 160 
Gly Ile Ile Thr Ala Phe Asn Phe Pro Val Ala Val Tyr Gly Trp Asn
                165                 170                 175     
Asn Ala Ile Ala Met Ile Cys Gly Asn Val Cys Leu Trp Lys Gly Ala
            180                 185                 190         
Pro Thr Thr Ser Leu Ile Ser Val Ala Val Thr Lys Ile Ile Ala Lys
        195                 200                 205             
Val Leu Glu Asp Asn Lys Leu Pro Gly Ala Ile Cys Ser Leu Thr Cys
    210                 215                 220                 
Gly Gly Ala Asp Ile Gly Thr Ala Met Ala Lys Asp Glu Arg Val Asn
225                 230                 235                 240 
Leu Leu Ser Phe Thr Gly Ser Thr Gln Val Gly Lys Gln Val Gly Leu
                245                 250                 255     
Met Val Gln Glu Arg Phe Gly Arg Ser Leu Leu Glu Leu Gly Gly Asn
            260                 265                 270         
Asn Ala Ile Ile Ala Phe Glu Asp Ala Asp Leu Ser Leu Val Val Pro
        275                 280                 285             
Ser Ala Leu Phe Ala Ala Val Gly Thr Ala Gly Gln Arg Cys Thr Thr
    290                 295                 300                 
Ala Arg Arg Leu Phe Ile His Glu Ser Ile His Asp Glu Val Val Asn
305                 310                 315                 320 
Arg Leu Lys Lys Ala Tyr Ala Gln Ile Arg Val Gly Asn Pro Trp Asp
                325                 330                 335     
Pro Asn Val Leu Tyr Gly Pro Leu His Thr Lys Gln Ala Val Ser Met
            340                 345                 350         
Phe Leu Gly Ala Val Glu Glu Ala Lys Lys Glu Gly Gly Thr Val Val
        355                 360                 365             
Tyr Gly Gly Lys Val Met Asp Arg Pro Gly Asn Tyr Val Glu Pro Thr
    370                 375                 380                 
Ile Val Thr Gly Leu Gly His Asp Ala Ser Ile Ala His Thr Glu Thr
385                 390                 395                 400 
Phe Ala Pro Ile Leu Tyr Val Phe Lys Phe Gln Asn Glu Glu Glu Val
                405                 410                 415     
Phe Ala Trp Asn Asn Glu Val Lys Gln Gly Leu Ser Ser Ser Ile Phe
            420                 425                 430         
Thr Lys Asp Leu Gly Arg Ile Phe Arg Trp Leu Gly Pro Lys Gly Ser
        435                 440                 445             
Asp Cys Gly Ile Val Asn Val Asn Ile Pro Thr Ser Gly Ala Glu Ile
    450                 455                 460                 
Gly Gly Ala Phe Gly Gly Glu Lys His Thr Gly Gly Gly Arg Glu Ser
465                 470                 475                 480 
Gly Ser Asp Ala Trp Lys Gln Tyr Met Arg Arg Ser Thr Cys Thr Ile
                485                 490                 495     
Asn Tyr Ser Lys Asp Leu Pro Leu Ala Gln Gly Ile Lys Phe Gln
            500                 505                 510     


<210> 1430
<211> 199
<212> PRT
<213> Homo sapiens

<400> 1430
Met Ala Asn Arg Gly Pro Ala Tyr Gly Leu Ser Arg Glu Val Gln Gln
 1               5                  10                  15      
Lys Ile Glu Lys Gln Tyr Asp Ala Asp Leu Glu Gln Ile Leu Ile Gln
            20                  25                  30          
Trp Ile Thr Thr Gln Cys Arg Lys Asp Val Gly Arg Pro Gln Pro Gly
        35                  40                  45              
Arg Glu Asn Phe Gln Asn Trp Leu Lys Asp Gly Thr Val Leu Cys Glu
    50                  55                  60                  
Leu Ile Asn Ala Gln Tyr Pro Glu Gly Gln Ala Pro Val Lys Lys Ile
65                  70                  75                  80  
Gln Ala Ser Thr Met Ala Phe Lys Gln Met Glu Gln Ile Ser Gln Phe
                85                  90                  95      
Leu Gln Ala Ala Glu Arg Tyr Gly Ile Asn Thr Thr Asp Ile Phe Gln
            100                 105                 110         
Thr Val Asp Leu Trp Glu Gly Lys Asn Met Ala Cys Val Gln Arg Thr
        115                 120                 125             
Leu Met Asn Leu Gly Gly Leu Ala Val Ala Arg Asp Asp Gly Leu Phe
    130                 135                 140                 
Ser Gly Asp Pro Asn Trp Phe Pro Lys Lys Ser Lys Glu Asn Pro Arg
145                 150                 155                 160 
Asn Phe Ser Asp Asn Gln Leu Gln Glu Gly Lys Asn Val Ile Gly Leu
                165                 170                 175     
Gln Met Gly Thr Asn Arg Gly Ala Ser Gln Ala Gly Met Thr Gly Tyr
            180                 185                 190         
Gly Met Pro Arg Gln Ile Leu
        195                 


<210> 1431
<211> 382
<212> PRT
<213> Homo sapiens

<400> 1431
Met Ser His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly
 1               5                  10                  15      
Tyr Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe
            20                  25                  30          
Ala Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala Pro Ala Ser
        35                  40                  45              
Val Leu Pro Ala Ala Thr Pro Arg Gln Ser Leu Gly His Pro Pro Pro
    50                  55                  60                  
Glu Pro Gly Pro Asp Arg Val Ala Asp Ala Lys Gly Asp Ser Glu Ser
65                  70                  75                  80  
Glu Glu Asp Glu Asp Leu Glu Val Pro Val Pro Ser Arg Phe Asn Arg
                85                  90                  95      
Arg Val Ser Val Cys Ala Glu Thr Tyr Asn Pro Asp Glu Glu Glu Glu
            100                 105                 110         
Asp Thr Asp Pro Arg Val Ile His Pro Lys Thr Asp Glu Gln Arg Cys
        115                 120                 125             
Arg Leu Gln Glu Ala Cys Lys Asp Ile Leu Leu Phe Lys Asn Leu Asp
    130                 135                 140                 
Gln Glu Gln Leu Ser Gln Val Leu Asp Ala Met Phe Glu Arg Ile Val
145                 150                 155                 160 
Lys Ala Asp Glu His Val Ile Asp Gln Gly Asp Asp Gly Asp Asn Phe
                165                 170                 175     
Tyr Val Ile Glu Arg Gly Thr Tyr Asp Ile Leu Val Thr Lys Asp Asn
            180                 185                 190         
Gln Thr Arg Ser Val Gly Gln Tyr Asp Asn Arg Gly Ser Phe Gly Glu
        195                 200                 205             
Leu Ala Leu Met Tyr Asn Thr Pro Arg Ala Ala Thr Ile Val Ala Thr
    210                 215                 220                 
Ser Glu Gly Ser Leu Trp Gly Leu Asp Arg Val Thr Phe Arg Arg Ile
225                 230                 235                 240 
Ile Val Lys Asn Asn Ala Lys Lys Arg Lys Met Phe Glu Ser Phe Ile
                245                 250                 255     
Glu Ser Val Pro Leu Leu Lys Ser Leu Glu Val Ser Glu Arg Met Lys
            260                 265                 270         
Ile Val Asp Val Ile Gly Glu Lys Ile Tyr Lys Asp Gly Glu Arg Ile
        275                 280                 285             
Ile Thr Gln Thr Lys Ser Asn Lys Asp Gly Gly Asn Gln Glu Val Glu
    290                 295                 300                 
Ile Ala Arg Cys His Lys Gly Gln Tyr Phe Gly Glu Leu Ala Leu Val
305                 310                 315                 320 
Thr Asn Lys Pro Arg Ala Ala Ser Ala Tyr Ala Val Gly Asp Val Lys
                325                 330                 335     
Cys Leu Val Met Asp Val Gln Ala Phe Glu Arg Leu Leu Gly Pro Cys
            340                 345                 350         
Met Asp Ile Met Lys Arg Asn Ile Ser His Tyr Glu Glu Gln Leu Val
        355                 360                 365             
Lys Met Phe Gly Ser Ser Val Asp Leu Gly Asn Leu Gly Gln
    370                 375                 380         


<210> 1432
<211> 212
<212> PRT
<213> Homo sapiens

<400> 1432
Arg Met Cys Met Arg His Arg Ser Ile Glu Thr Lys Leu Arg Gln Phe
 1               5                  10                  15      
Thr Asn Ala Leu Leu Glu Ser Leu Ile Asn Pro Leu Gln Glu Arg Ile
            20                  25                  30          
Glu Asp Trp Lys Lys Ala Ala Asn Gln Leu Asp Lys Asp His Ala Lys
        35                  40                  45              
Glu Tyr Lys Arg Ala Arg His Glu Ile Lys Lys Lys Ser Ser Asp Thr
    50                  55                  60                  
Leu Lys Leu Gln Lys Lys Ala Arg Lys Gly Lys Gly Asp Leu Gln Pro
65                  70                  75                  80  
Gln Leu Asp Ser Ala Leu Gln Asp Val Asn Asp Met Tyr Leu Leu Leu
                85                  90                  95      
Glu Glu Thr Glu Lys Gln Ala Val Arg Arg Ala Leu Ile Glu Glu Arg
            100                 105                 110         
Gly Arg Phe Cys Thr Phe Ile Thr Phe Leu Gln Pro Val Val Asn Gly
        115                 120                 125             
Glu Leu Thr Met Leu Gly Glu Ile Thr His Leu Gln Gly Ile Ile Asp
    130                 135                 140                 
Asp Leu Val Val Leu Thr Ala Glu Pro His Lys Leu Pro Pro Ala Ser
145                 150                 155                 160 
Glu Gln Val Ile Lys Asp Leu Lys Gly Ser Asp Tyr Ser Trp Ser Tyr
                165                 170                 175     
Gln Thr Pro Pro Ser Val Pro Ser Glu Pro Phe Val Ser Phe Leu Ser
            180                 185                 190         
Val Arg Phe Trp Lys Asn Ser Pro Leu Leu Pro Ala Pro Ser Thr Pro
        195                 200                 205             
Ser Ser Pro Ile
    210         


<210> 1433
<211> 562
<212> PRT
<213> Homo sapiens

<400> 1433
Met Val Lys Ser Arg Leu Asn Ser Trp Phe Gln His Arg Pro Pro Gly
 1               5                  10                  15      
Ala Ser Pro Glu Arg Tyr Leu Gly Leu Pro Gly Ser Leu Lys Trp Glu
            20                  25                  30          
Asp Arg Gly Pro Ser Gly Gln Gly Gln Gly Gln Phe Leu Ile Gln Gln
        35                  40                  45              
Val Thr Leu Lys Ile Pro Ile Ser Ile Glu Phe Val Phe Glu Ser Gly
    50                  55                  60                  
Ser Ala Gln Ala Gly Gly Asn Gln Ala Leu Pro Arg Leu Ala Gly Ser
65                  70                  75                  80  
Leu Leu Thr Gln Ala Leu Glu Ser His Ala Glu Gly Phe Arg Glu Arg
                85                  90                  95      
Phe Glu Lys Thr Phe Gln Leu Lys Glu Lys Gly Leu Ser Ser Gly Glu
            100                 105                 110         
Gln Val Leu Gly Gln Ala Ala Leu Ser Gly Leu Leu Gly Gly Ile Gly
        115                 120                 125             
Tyr Phe Tyr Gly Gln Gly Leu Val Leu Pro Asp Ile Gly Val Glu Gly
    130                 135                 140                 
Ser Glu Gln Lys Val Asp Pro Ala Leu Phe Pro Pro Val Pro Leu Phe
145                 150                 155                 160 
Thr Ala Val Pro Ser Arg Ser Phe Phe Pro Arg Gly Phe Leu Trp Asp
                165                 170                 175     
Glu Gly Phe His Gln Leu Val Val Gln Arg Trp Asp Pro Ser Leu Thr
            180                 185                 190         
Arg Glu Ala Leu Gly His Trp Leu Gly Leu Leu Asn Ala Asp Gly Trp
        195                 200                 205             
Ile Gly Arg Glu Gln Ile Leu Gly Asp Glu Ala Arg Ala Arg Val Pro
    210                 215                 220                 
Pro Glu Phe Leu Val Gln Arg Ala Val His Ala Asn Pro Pro Thr Leu
225                 230                 235                 240 
Leu Leu Pro Val Ala His Met Leu Glu Val Gly Asp Pro Asp Asp Leu
                245                 250                 255     
Ala Phe Leu Arg Lys Ala Leu Pro Arg Leu His Ala Trp Phe Ser Trp
            260                 265                 270         
Leu His Gln Ser Gln Ala Gly Pro Leu Pro Leu Ser Tyr Arg Trp Arg
        275                 280                 285             
Gly Arg Asp Pro Ala Leu Pro Thr Leu Leu Asn Pro Lys Thr Leu Pro
    290                 295                 300                 
Ser Gly Leu Asp Asp Tyr Pro Arg Ala Ser His Pro Ser Val Thr Glu
305                 310                 315                 320 
Arg His Leu Asp Leu Arg Cys Trp Val Ala Leu Gly Ala Arg Val Leu
                325                 330                 335     
Thr Arg Leu Ala Glu His Leu Gly Glu Ala Glu Val Ala Ala Glu Leu
            340                 345                 350         
Gly Pro Leu Ala Ala Ser Leu Glu Ala Ala Glu Ser Leu Asp Glu Leu
        355                 360                 365             
His Trp Ala Pro Glu Leu Gly Val Phe Ala Asp Phe Gly Asn His Thr
    370                 375                 380                 
Lys Ala Val Gln Leu Lys Pro Arg Pro Pro Gln Gly Leu Val Arg Val
385                 390                 395                 400 
Val Gly Arg Pro Gln Pro Gln Leu Gln Tyr Val Asp Ala Leu Gly Tyr
                405                 410                 415     
Val Ser Leu Phe Pro Leu Leu Leu Arg Leu Leu Asp Pro Thr Ser Ser
            420                 425                 430         
Arg Leu Gly Pro Leu Leu Asp Ile Leu Ala Asp Ser Arg His Leu Trp
        435                 440                 445             
Ser Pro Phe Gly Leu Arg Ser Leu Ala Ala Ser Ser Ser Phe Tyr Gly
    450                 455                 460                 
Gln Arg Asn Ser Glu His Asp Pro Pro Tyr Trp Arg Gly Ala Val Trp
465                 470                 475                 480 
Leu Asn Val Asn Tyr Leu Ala Leu Gly Ala Leu His His Tyr Gly His
                485                 490                 495     
Leu Glu Gly Pro His Gln Ala Arg Ala Ala Lys Leu His Gly Glu Leu
            500                 505                 510         
Arg Ala Asn Val Val Gly Asn Val Trp Arg Gln Tyr Gln Ala Thr Gly
        515                 520                 525             
Phe Leu Trp Glu Gln Tyr Ser Asp Arg Asp Gly Arg Gly Met Gly Cys
    530                 535                 540                 
Arg Pro Phe His Gly Trp Thr Ser Leu Val Leu Leu Ala Met Ala Glu
545                 550                 555                 560 
Asp Tyr
        


<210> 1434
<211> 184
<212> PRT
<213> Homo sapiens

<400> 1434
Met Ala Thr Ala Leu Ala Leu Arg Ser Leu Tyr Arg Ala Arg Pro Ser
 1               5                  10                  15      
Leu Arg Cys Pro Pro Val Glu Leu Pro Trp Ala Pro Arg Arg Gly His
            20                  25                  30          
Arg Leu Ser Pro Ala Asp Asp Glu Leu Tyr Gln Arg Thr Arg Ile Ser
        35                  40                  45              
Leu Leu Gln Arg Glu Ala Ala Gln Ala Met Tyr Ile Asp Ser Tyr Asn
    50                  55                  60                  
Ser Arg Gly Phe Met Ile Asn Gly Asn Arg Val Leu Gly Pro Cys Ala
65                  70                  75                  80  
Leu Leu Pro His Ser Val Val Gln Trp Asn Val Gly Ser His Gln Asp
                85                  90                  95      
Ile Thr Glu Asp Ser Phe Ser Leu Phe Trp Leu Leu Glu Pro Arg Ile
            100                 105                 110         
Glu Ile Val Val Val Gly Thr Gly Asp Arg Thr Glu Arg Leu Gln Ser
        115                 120                 125             
Gln Val Leu Gln Ala Met Arg Gln Arg Gly Ile Ala Val Glu Val Gln
    130                 135                 140                 
Asp Thr Pro Asn Ala Cys Ala Thr Phe Asn Phe Leu Cys His Glu Gly
145                 150                 155                 160 
Arg Val Thr Gly Ala Ala Leu Ile Pro Pro Pro Gly Gly Thr Ser Leu
                165                 170                 175     
Thr Ser Leu Gly Gln Ala Ala Gln
            180                 


<210> 1435
<211> 314
<212> PRT
<213> Homo sapiens

<400> 1435
Ala Arg Gly Gly Ile Ile Arg Arg Ile Gln Thr Arg Gly Glu Gly Tyr
 1               5                  10                  15      
Ala Lys Pro Asn Glu Gly Ala Ile Val Glu Val Ala Leu Glu Gly Tyr
            20                  25                  30          
Tyr Lys Asp Lys Leu Phe Asp Gln Arg Glu Leu Arg Phe Glu Ile Gly
        35                  40                  45              
Glu Gly Glu Asn Leu Asp Leu Pro Tyr Gly Leu Glu Arg Ala Ile Gln
    50                  55                  60                  
Arg Met Glu Lys Gly Glu His Ser Ile Val Tyr Leu Lys Pro Ser Tyr
65                  70                  75                  80  
Ala Phe Gly Ser Val Gly Lys Glu Lys Phe Gln Ile Pro Pro Asn Ala
                85                  90                  95      
Glu Leu Lys Tyr Glu Leu His Leu Lys Ser Phe Glu Lys Ala Lys Glu
            100                 105                 110         
Ser Trp Glu Met Asn Ser Glu Glu Lys Leu Glu Gln Ser Thr Ile Val
        115                 120                 125             
Lys Glu Arg Gly Thr Val Tyr Phe Lys Glu Gly Lys Tyr Lys Gln Ala
    130                 135                 140                 
Leu Leu Gln Tyr Lys Lys Ile Val Ser Trp Leu Glu Tyr Glu Ser Ser
145                 150                 155                 160 
Phe Ser Asn Glu Glu Ala Gln Lys Ala Gln Ala Leu Arg Leu Ala Ser
                165                 170                 175     
His Leu Asn Leu Ala Met Cys His Leu Lys Leu Gln Ala Phe Ser Ala
            180                 185                 190         
Ala Ile Glu Ser Cys Asn Lys Ala Leu Glu Leu Asp Ser Asn Asn Glu
        195                 200                 205             
Lys Gly Leu Phe Arg Arg Gly Glu Ala His Leu Ala Val Asn Asp Phe
    210                 215                 220                 
Glu Leu Ala Arg Ala Asp Phe Gln Lys Val Leu Gln Leu Tyr Pro Asn
225                 230                 235                 240 
Asn Lys Ala Ala Lys Thr Gln Leu Ala Val Cys Gln Gln Arg Ile Arg
                245                 250                 255     
Arg Gln Leu Ala Arg Glu Lys Lys Leu Tyr Ala Asn Met Phe Glu Arg
            260                 265                 270         
Leu Ala Glu Glu Glu Asn Lys Ala Lys Ala Glu Ala Ser Ser Gly Asp
        275                 280                 285             
His Pro Thr Asp Thr Glu Met Lys Glu Glu Gln Lys Ser Asn Thr Ala
    290                 295                 300                 
Gly Ser Gln Ser Gln Val Glu Thr Glu Ala
305                 310                 


<210> 1436
<211> 597
<212> PRT
<213> Homo sapiens

<400> 1436
Met Asp Asp Lys Gly Glu Val Lys Cys Ile Lys Phe Ser Leu Glu Asn
 1               5                  10                  15      
Lys Ile Leu Ala Val Gln Arg Thr Ser Lys Thr Val Asp Phe Cys Asn
            20                  25                  30          
Phe Ile Pro Asp Asn Ser Gln Leu Glu Tyr Thr Gln Glu Cys Lys Thr
        35                  40                  45              
Lys Asn Ala Asn Ile Leu Gly Phe Cys Trp Thr Ser Ser Thr Glu Ile
    50                  55                  60                  
Val Phe Ile Thr Asp Gln Gly Ile Glu Phe Tyr Gln Val Leu Pro Glu
65                  70                  75                  80  
Lys Arg Ser Leu Lys Leu Leu Lys Ser His Asn Leu Asn Val Asn Trp
                85                  90                  95      
Tyr Met Tyr Cys Pro Glu Ser Ala Val Ile Leu Leu Ser Thr Thr Val
            100                 105                 110         
Leu Glu Asn Val Leu Gln Pro Phe His Phe Arg Ala Gly Thr Met Ser
        115                 120                 125             
Lys Leu Pro Lys Phe Glu Ile Glu Leu Pro Ala Ala Pro Lys Ser Thr
    130                 135                 140                 
Lys Pro Ser Leu Ser Glu Arg Asp Ile Ala Met Ala Thr Ile Tyr Gly
145                 150                 155                 160 
Gln Leu Tyr Val Leu Phe Leu Arg His His Ser Arg Thr Ser Asn Ser
                165                 170                 175     
Thr Gly Ala Glu Val Val Leu Tyr His Leu Pro Arg Glu Gly Ala Cys
            180                 185                 190         
Lys Lys Met His Ile Leu Lys Leu Asn Arg Thr Gly Lys Phe Ala Leu
        195                 200                 205             
Asn Val Val Asp Asn Leu Val Val Val His His Gln Asp Thr Glu Thr
    210                 215                 220                 
Ser Val Ile Phe Asp Ile Lys Leu Arg Gly Glu Phe Asp Gly Ser Val
225                 230                 235                 240 
Thr Phe His His Pro Val Leu Pro Ala Arg Ser Ile Gln Pro Tyr Gln
                245                 250                 255     
Ile Pro Ile Thr Gly Pro Ala Ala Val Thr Ser Gln Ser Pro Val Pro
            260                 265                 270         
Cys Lys Leu Tyr Ser Ser Ser Trp Ile Val Phe Gln Pro Asp Ile Ile
        275                 280                 285             
Ile Ser Ala Ser Gln Gly Tyr Leu Trp Asn Leu Gln Val Lys Leu Glu
    290                 295                 300                 
Pro Ile Val Asn Leu Leu Pro Asp Lys Gly Arg Leu Met Asp Phe Leu
305                 310                 315                 320 
Leu Gln Arg Lys Glu Cys Lys Met Val Ile Leu Ser Val Cys Ser Gln
                325                 330                 335     
Met Leu Ser Glu Ser Asp Arg Ala Ser Leu Pro Val Ile Ala Thr Val
            340                 345                 350         
Phe Asp Lys Leu Asn His Glu Tyr Lys Lys Tyr Leu Asp Ala Glu Gln
        355                 360                 365             
Ser Tyr Ala Met Ala Val Glu Ala Gly Gln Ser Arg Ser Ser Pro Leu
    370                 375                 380                 
Leu Lys Arg Pro Val Arg Thr Gln Ala Val Leu Asp Gln Ser Asp Val
385                 390                 395                 400 
Tyr Thr His Val Leu Ser Ala Phe Val Glu Lys Lys Glu Met Pro His
                405                 410                 415     
Lys Phe Val Ile Ala Val Leu Met Glu Tyr Ile Arg Ser Leu Asn Gln
            420                 425                 430         
Phe Gln Ile Ala Val Gln His Tyr Leu His Glu Leu Val Ile Lys Thr
        435                 440                 445             
Leu Val Gln His Asn Leu Phe Tyr Met Leu His Gln Phe Leu Gln Tyr
    450                 455                 460                 
His Val Leu Ser Asp Ser Lys Pro Leu Ala Cys Leu Leu Leu Ser Leu
465                 470                 475                 480 
Glu Ser Phe Tyr Pro Pro Ala His Gln Leu Ser Leu Asp Met Leu Lys
                485                 490                 495     
Arg Leu Ser Thr Ala Asn Asp Glu Ile Val Glu Val Leu Leu Ser Lys
            500                 505                 510         
His Gln Val Leu Ala Ala Leu Arg Phe Ile Arg Gly Ile Gly Gly His
        515                 520                 525             
Asp Asn Ile Ser Ala Arg Lys Phe Leu Asp Ala Ala Lys Gln Thr Glu
    530                 535                 540                 
Asp Asn Met Leu Phe Tyr Thr Ile Phe Arg Phe Phe Glu Gln Arg Asn
545                 550                 555                 560 
Gln Arg Leu Arg Gly Ser Pro Asn Phe Thr Pro Gly Glu His Cys Glu
                565                 570                 575     
Glu His Val Ala Phe Phe Lys Gln Ile Phe Gly Asp Gln Ala Leu Met
            580                 585                 590         
Arg Pro Thr Thr Phe
        595         


<210> 1437
<211> 539
<212> PRT
<213> Homo sapiens

<400> 1437
Ser Met Gly Thr Leu Ala Phe Asp Glu Tyr Gly Arg Pro Phe Leu Ile
 1               5                  10                  15      
Ile Lys Asp Gln Asp Arg Lys Ser Arg Leu Met Gly Leu Glu Ala Leu
            20                  25                  30          
Lys Ser His Ile Met Ala Ala Lys Ala Val Ala Asn Thr Met Arg Thr
        35                  40                  45              
Ser Leu Gly Pro Asn Gly Leu Asp Lys Met Met Val Asp Lys Asp Gly
    50                  55                  60                  
Asp Val Thr Val Thr Asn Asp Gly Ala Thr Ile Leu Ser Met Met Asp
65                  70                  75                  80  
Val Asp His Gln Ile Ala Lys Leu Met Val Glu Leu Ser Lys Ser Gln
                85                  90                  95      
Asp Asp Glu Ile Gly Asp Gly Thr Thr Gly Val Val Val Leu Ala Gly
            100                 105                 110         
Ala Leu Leu Glu Glu Ala Glu Gln Leu Leu Asp Arg Gly Ile His Pro
        115                 120                 125             
Ile Arg Ile Ala Asp Gly Tyr Glu Gln Ala Ala Arg Val Ala Ile Glu
    130                 135                 140                 
His Leu Asp Lys Ile Ser Asp Ser Val Leu Val Asp Ile Lys Asp Thr
145                 150                 155                 160 
Glu Pro Leu Ile Gln Thr Ala Lys Thr Thr Leu Gly Ser Lys Val Val
                165                 170                 175     
Asn Ser Cys His Arg Gln Met Ala Glu Ile Ala Val Asn Ala Val Leu
            180                 185                 190         
Thr Val Ala Asp Met Glu Arg Arg Asp Val Asp Phe Glu Leu Ile Lys
        195                 200                 205             
Val Glu Gly Lys Val Gly Gly Arg Leu Glu Asp Thr Lys Leu Ile Lys
    210                 215                 220                 
Gly Val Ile Val Asp Lys Asp Phe Ser His Pro Gln Met Pro Lys Lys
225                 230                 235                 240 
Val Glu Asp Ala Lys Ile Ala Ile Leu Thr Cys Pro Phe Glu Pro Pro
                245                 250                 255     
Lys Pro Lys Thr Lys His Lys Leu Asp Val Thr Ser Val Glu Asp Tyr
            260                 265                 270         
Lys Ala Leu Gln Lys Tyr Glu Lys Glu Lys Phe Glu Glu Met Ile Gln
        275                 280                 285             
Gln Ile Lys Glu Thr Gly Ala Asn Leu Ala Ile Cys Gln Trp Gly Phe
    290                 295                 300                 
Asp Asp Glu Ala Asn His Leu Leu Leu Gln Asn Asn Leu Pro Ala Val
305                 310                 315                 320 
Arg Trp Val Gly Gly Pro Glu Ile Glu Leu Ile Ala Ile Ala Thr Gly
                325                 330                 335     
Gly Arg Ile Val Pro Arg Phe Ser Glu Leu Thr Ala Glu Lys Leu Gly
            340                 345                 350         
Phe Ala Gly Leu Val Gln Glu Ile Ser Phe Gly Thr Thr Lys Asp Lys
        355                 360                 365             
Met Leu Val Ile Glu Gln Cys Lys Asn Ser Arg Ala Val Thr Ile Phe
    370                 375                 380                 
Ile Arg Gly Gly Asn Lys Met Ile Ile Glu Glu Ala Lys Arg Ser Leu
385                 390                 395                 400 
His Asp Ala Leu Cys Val Ile Arg Asn Leu Ile Arg Asp Asn Arg Val
                405                 410                 415     
Val Tyr Gly Gly Gly Ala Ala Glu Ile Ser Cys Ala Leu Ala Val Ser
            420                 425                 430         
Gln Glu Ala Asp Lys Cys Pro Thr Leu Glu Gln Tyr Ala Met Arg Ala
        435                 440                 445             
Phe Ala Asp Ala Leu Glu Val Ile Pro Met Ala Leu Ser Glu Asn Ser
    450                 455                 460                 
Gly Met Asn Pro Ile Gln Thr Met Thr Glu Val Arg Ala Arg Gln Val
465                 470                 475                 480 
Lys Glu Met Asn Pro Ala Leu Gly Ile Asp Cys Leu His Lys Gly Thr
                485                 490                 495     
Asn Asp Met Lys Gln Gln His Val Ile Glu Thr Leu Ile Gly Lys Lys
            500                 505                 510         
Gln Gln Ile Ser Leu Ala Thr Gln Met Val Arg Met Ile Leu Lys Ile
        515                 520                 525             
Asp Asp Ile Arg Lys Pro Gly Glu Ser Glu Glu
    530                 535                 


<210> 1438
<211> 475
<212> PRT
<213> Homo sapiens

<400> 1438
Glu Thr Pro Gly Ala Ser Ala Ser Ser Leu Leu Leu Pro Ala Ala Ser
 1               5                  10                  15      
Arg Pro Pro Arg Lys Arg Glu Ala Gly Glu Ala Gly Ala Ala Thr Ser
            20                  25                  30          
Lys Gln Arg Val Leu Asp Glu Glu Glu Tyr Ile Glu Gly Leu Gln Thr
        35                  40                  45              
Val Ile Gln Arg Asp Phe Phe Pro Asp Val Glu Lys Leu Gln Ala Gln
    50                  55                  60                  
Lys Glu Tyr Leu Glu Ala Glu Glu Asn Gly Asp Leu Glu Arg Met Arg
65                  70                  75                  80  
Gln Ile Ala Ile Lys Phe Gly Ser Ala Leu Gly Lys Met Ser Arg Glu
                85                  90                  95      
Pro Pro Pro Pro Tyr Val Thr Pro Ala Thr Phe Glu Thr Pro Glu Val
            100                 105                 110         
His Ala Gly Thr Gly Val Val Gly Asn Lys Pro Arg Pro Arg Gly Arg
        115                 120                 125             
Gly Leu Glu Asp Gly Glu Ala Gly Glu Glu Glu Glu Lys Glu Pro Leu
    130                 135                 140                 
Pro Ser Leu Asp Val Phe Leu Ser Arg Tyr Thr Ser Glu Asp Asn Ala
145                 150                 155                 160 
Ser Phe Gln Glu Ile Met Glu Val Ala Lys Glu Arg Ser Arg Ala Arg
                165                 170                 175     
His Ala Trp Leu Tyr Gln Ala Glu Glu Glu Phe Glu Lys Arg Gln Lys
            180                 185                 190         
Asp Asn Leu Glu Leu Pro Ser Ala Glu His Gln Ala Ile Glu Ser Ser
        195                 200                 205             
Gln Ala Ser Val Glu Thr Trp Lys Tyr Lys Ala Lys Asn Ser Leu Met
    210                 215                 220                 
Tyr Tyr Pro Glu Gly Val Pro Asp Glu Glu Gln Leu Phe Lys Lys Pro
225                 230                 235                 240 
Arg Gln Val Val His Lys Asn Thr Arg Phe Leu Arg Asp Pro Phe Ser
                245                 250                 255     
Gln Ala Leu Ser Arg Cys Gln Leu Gln Gln Ala Ala Ala Leu Asn Ala
            260                 265                 270         
Gln His Lys Gln Gly Lys Val Gly Pro Asp Gly Lys Glu Leu Ile Pro
        275                 280                 285             
Gln Glu Ser Pro Arg Val Gly Gly Phe Gly Phe Val Ala Thr Pro Ser
    290                 295                 300                 
Pro Ala Pro Gly Val Asn Glu Ser Pro Met Met Thr Trp Gly Glu Val
305                 310                 315                 320 
Glu Asn Thr Pro Leu Arg Val Glu Gly Ser Glu Thr Pro Tyr Val Asp
                325                 330                 335     
Arg Thr Pro Gly Pro Ala Phe Lys Ile Leu Glu Pro Gly Arg Arg Glu
            340                 345                 350         
Arg Leu Gly Leu Lys Met Ala Asn Glu Ala Ala Ala Lys Asn Arg Ala
        355                 360                 365             
Lys Lys Gln Glu Ala Leu Arg Arg Val Thr Glu Asn Leu Ala Ser Leu
    370                 375                 380                 
Thr Pro Lys Gly Leu Ser Pro Ala Met Ser Pro Ala Leu Gln Arg Leu
385                 390                 395                 400 
Val Ser Arg Thr Ala Ser Lys Tyr Thr Asp Arg Ala Leu Arg Ala Ser
                405                 410                 415     
Tyr Thr Pro Ser Pro Ala Arg Ser Thr His Leu Lys Thr Pro Ala Ser
            420                 425                 430         
Gly Leu Gln Thr Pro Thr Ser Thr Pro Ala Pro Gly Ser Ala Thr Arg
        435                 440                 445             
Thr Pro Leu Thr Gln Asp Pro Ala Ser Ile Thr Asp Asn Leu Leu Gln
    450                 455                 460                 
Leu Pro Ala Arg Arg Lys Ala Ser Asp Phe Phe
465                 470                 475 


<210> 1439
<211> 243
<212> PRT
<213> Homo sapiens

<400> 1439
Glu Leu Phe Leu Ala Gly Arg Arg Val Leu Val Thr Gly Ala Gly Lys
 1               5                  10                  15      
Gly Ile Gly Arg Gly Thr Val Gln Ala Leu His Ala Thr Gly Ala Arg
            20                  25                  30          
Val Val Ala Val Ser Arg Thr Gln Ala Asp Leu Asp Ser Leu Val Arg
        35                  40                  45              
Glu Cys Pro Gly Ile Glu Pro Val Cys Val Asp Leu Gly Asp Trp Glu
    50                  55                  60                  
Ala Thr Glu Arg Ala Leu Gly Ser Val Gly Pro Val Asp Leu Leu Val
65                  70                  75                  80  
Asn Asn Ala Ala Val Ala Leu Leu Gln Pro Phe Leu Glu Val Thr Lys
                85                  90                  95      
Glu Ala Phe Asp Arg Ser Phe Glu Val Asn Leu Arg Ala Val Ile Gln
            100                 105                 110         
Val Ser Gln Ile Val Ala Arg Gly Leu Ile Ala Arg Gly Val Pro Gly
        115                 120                 125             
Ala Ile Val Asn Val Ser Ser Gln Cys Ser Gln Arg Ala Val Thr Asn
    130                 135                 140                 
His Ser Val Tyr Cys Ser Thr Lys Gly Ala Leu Asp Met Leu Thr Lys
145                 150                 155                 160 
Val Met Ala Leu Glu Leu Gly Pro His Lys Ile Arg Val Asn Ala Val
                165                 170                 175     
Asn Pro Thr Val Val Met Thr Ser Met Gly Gln Ala Thr Trp Ser Asp
            180                 185                 190         
Pro His Lys Ala Lys Thr Met Leu Asn Arg Ile Pro Leu Gly Lys Phe
        195                 200                 205             
Ala Glu Val Glu His Val Val Asn Ala Ile Leu Phe Leu Leu Ser Asp
    210                 215                 220                 
Arg Ser Gly Met Thr Thr Gly Ser Thr Leu Pro Val Glu Gly Gly Phe
225                 230                 235                 240 
Trp Ala Cys
            


<210> 1440
<211> 402
<212> PRT
<213> Homo sapiens

<400> 1440
His Ala Asp Val Tyr Thr Phe Asn Ala Leu Ile Glu Ala Thr Val Cys
 1               5                  10                  15      
Ala Ile Asn Glu Lys Phe Glu Glu Lys Trp Ser Lys Ile Leu Glu Leu
            20                  25                  30          
Leu Arg His Met Val Ala Gln Lys Val Lys Pro Asn Leu Gln Thr Phe
        35                  40                  45              
Asn Thr Ile Leu Lys Cys Leu Arg Arg Phe His Val Phe Ala Arg Ser
    50                  55                  60                  
Pro Ala Leu Gln Val Leu Arg Glu Met Lys Ala Ile Gly Ile Glu Pro
65                  70                  75                  80  
Ser Leu Ala Thr Tyr His His Ile Ile Arg Leu Phe Asp Gln Pro Gly
                85                  90                  95      
Asp Pro Leu Lys Arg Ser Ser Phe Ile Ile Tyr Asp Ile Met Asn Glu
            100                 105                 110         
Leu Met Gly Lys Arg Phe Ser Pro Lys Asp Pro Asp Asp Asp Lys Phe
        115                 120                 125             
Phe Gln Ser Ala Met Ser Ile Cys Ser Ser Leu Arg Asp Leu Glu Leu
    130                 135                 140                 
Ala Tyr Gln Val His Gly Leu Leu Lys Thr Gly Asp Asn Trp Lys Phe
145                 150                 155                 160 
Ile Gly Pro Asp Gln His Arg Asn Phe Tyr Tyr Ser Lys Phe Phe Asp
                165                 170                 175     
Leu Ile Cys Leu Met Glu Gln Ile Asp Val Thr Leu Lys Trp Tyr Glu
            180                 185                 190         
Asp Leu Ile Pro Ser Ala Tyr Phe Leu His Ser Gln Thr Met Ile His
        195                 200                 205             
Leu Leu Gln Ala Leu Asp Val Ala Asn Arg Leu Glu Val Ile Pro Lys
    210                 215                 220                 
Ile Trp Lys Asp Ser Lys Glu Tyr Gly His Thr Phe Arg Ser Asp Leu
225                 230                 235                 240 
Arg Glu Glu Ile Leu Met Leu Met Ala Arg Asp Lys His Pro Pro Glu
                245                 250                 255     
Leu Gln Val Ala Phe Ala Asp Cys Ala Ala Asp Ile Lys Ser Ala Tyr
            260                 265                 270         
Glu Ser Gln Pro Ile Arg Gln Thr Ala Gln Asp Trp Pro Ala Thr Ser
        275                 280                 285             
Leu Asn Cys Ile Ala Ile Leu Phe Leu Arg Ala Gly Arg Thr Gln Glu
    290                 295                 300                 
Ala Trp Lys Met Leu Gly Leu Phe Arg Lys His Asn Lys Ile Pro Arg
305                 310                 315                 320 
Ser Glu Leu Leu Asn Glu Leu Met Asp Ser Ala Lys Val Ser Asn Ser
                325                 330                 335     
Pro Ser Gln Ala Ile Glu Val Val Glu Leu Ala Ser Ala Phe Ser Leu
            340                 345                 350         
Pro Ile Cys Glu Gly Leu Thr Gln Arg Val Met Ser Asp Phe Ala Ile
        355                 360                 365             
Asn Gln Glu Gln Lys Glu Ala Leu Ser Asn Leu Thr Ala Leu Thr Ser
    370                 375                 380                 
Asp Ser Asp Thr Asp Ser Ser Ser Asp Ser Asp Ser Asp Thr Ser Glu
385                 390                 395                 400 
Gly Lys
        


<210> 1441
<211> 198
<212> PRT
<213> Homo sapiens

<400> 1441
Glu Phe Gln Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu
 1               5                  10                  15      
Ala Thr Tyr Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln
            20                  25                  30          
Leu Ser Val Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln
        35                  40                  45              
Met Val Lys Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu
    50                  55                  60                  
Leu Tyr Arg Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala
65                  70                  75                  80  
Thr Ile Lys Thr Lys Arg Ser Ile Gln Phe Val Asp Trp Cys Pro Thr
                85                  90                  95      
Gly Phe Lys Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly
            100                 105                 110         
Gly Asp Leu Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr
        115                 120                 125             
Thr Ala Ile Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu
    130                 135                 140                 
Met Tyr Ala Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met
145                 150                 155                 160 
Glu Glu Gly Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu
                165                 170                 175     
Lys Asp Tyr Glu Glu Val Gly Val Asp Ser Val Glu Gly Glu Gly Glu
            180                 185                 190         
Glu Glu Gly Glu Glu Tyr
        195             


<210> 1442
<211> 188
<212> PRT
<213> Homo sapiens

<400> 1442
Met Tyr Ile Ala Leu Thr Gly Leu Gln His Ala Gly Arg Ile Leu Thr
 1               5                  10                  15      
Thr Arg Ile His Glu Leu Lys Gln Ala Lys Val Ser Thr Val Met Asp
            20                  25                  30          
Thr Val Gly Arg Arg Leu Arg Asp Ser Leu Gly Arg Thr Val Asp Leu
        35                  40                  45              
Gly Leu Thr Gly Asn His Gly Val Val His Pro Ser Leu Ala Asp Ser
    50                  55                  60                  
Ala Asn Lys Phe Glu Glu Asn Thr Tyr Cys Phe Gly Arg Thr Val Glu
65                  70                  75                  80  
Thr Leu Leu Leu Arg Phe Gly Lys Thr Ile Met Glu Glu Gln Leu Val
                85                  90                  95      
Leu Lys Arg Val Ala Asn Ile Leu Ile Asn Leu Tyr Gly Met Thr Ala
            100                 105                 110         
Val Leu Ser Arg Ala Ser Arg Ser Ile Arg Ile Gly Leu Arg Asn His
        115                 120                 125             
Asp His Glu Val Leu Leu Ala Asn Thr Phe Cys Val Glu Ala Tyr Leu
    130                 135                 140                 
Gln Asn Leu Phe Ser Leu Ser Gln Leu Asp Lys Tyr Ala Pro Glu Asn
145                 150                 155                 160 
Leu Asp Glu Gln Ile Lys Lys Val Ser Gln Gln Ile Leu Glu Lys Arg
                165                 170                 175     
Ala Tyr Ile Cys Ala His Pro Leu Asp Arg Thr Cys
            180                 185             


<210> 1443
<211> 132
<212> PRT
<213> Homo sapiens

<400> 1443
His Glu Ala Glu Ala Glu Arg Val Leu Arg Tyr Leu Val Glu Val Glu
 1               5                  10                  15      
Glu Leu Ala Glu Glu Val Leu Ala Asp Lys Arg Gln Ile Val Asp Leu
            20                  25                  30          
Asp Thr Lys Arg Asn Gln Asn Arg Glu Gly Leu Arg Ala Leu Gln Lys
        35                  40                  45              
Asp Leu Ser Leu Ser Glu Asp Val Met Val Cys Phe Gly Asn Met Phe
    50                  55                  60                  
Ile Lys Met Pro His Pro Glu Thr Lys Glu Met Ile Glu Lys Asp Gln
65                  70                  75                  80  
Asp His Leu Asp Lys Glu Ile Glu Lys Leu Arg Lys Gln Leu Lys Val
                85                  90                  95      
Lys Val Asn Arg Leu Phe Glu Ala Gln Gly Lys Pro Glu Leu Lys Gly
            100                 105                 110         
Phe Asn Leu Asn Pro Leu Asn Gln Asp Glu Leu Lys Ala Leu Lys Val
        115                 120                 125             
Ile Leu Lys Gly
    130         


<210> 1444
<211> 392
<212> PRT
<213> Homo sapiens

<400> 1444
Met Ala Ala Ala Ala Leu Gly Gln Ile Trp Ala Arg Lys Leu Leu Ser
 1               5                  10                  15      
Val Pro Trp Leu Leu Cys Gly Pro Arg Arg Tyr Ala Ser Ser Ser Phe
            20                  25                  30          
Lys Ala Ala Asp Leu Gln Leu Glu Met Thr Gln Lys Pro His Lys Lys
        35                  40                  45              
Pro Gly Pro Gly Glu Pro Leu Val Phe Gly Lys Thr Phe Thr Asp His
    50                  55                  60                  
Met Leu Met Val Glu Trp Asn Asp Lys Gly Trp Gly Gln Pro Arg Ile
65                  70                  75                  80  
Gln Pro Phe Gln Asn Leu Thr Leu His Pro Ala Ser Ser Ser Leu His
                85                  90                  95      
Tyr Ser Leu Gln Leu Phe Glu Gly Met Lys Ala Phe Lys Gly Lys Asp
            100                 105                 110         
Gln Gln Val Arg Leu Phe Arg Pro Trp Leu Asn Met Asp Arg Met Leu
        115                 120                 125             
Arg Ser Ala Met Arg Leu Cys Leu Pro Ser Phe Asp Lys Leu Glu Leu
    130                 135                 140                 
Leu Glu Cys Ile Arg Arg Leu Ile Glu Val Asp Lys Asp Trp Val Pro
145                 150                 155                 160 
Asp Ala Ala Gly Thr Ser Leu Tyr Val Arg Pro Val Leu Ile Gly Asn
                165                 170                 175     
Glu Pro Ser Leu Gly Val Ser Gln Pro Thr Arg Ala Leu Leu Phe Val
            180                 185                 190         
Ile Leu Cys Pro Val Gly Ala Tyr Phe Pro Gly Gly Ser Val Thr Pro
        195                 200                 205             
Val Ser Leu Leu Ala Asp Pro Ala Phe Ile Arg Ala Trp Val Gly Gly
    210                 215                 220                 
Val Gly Asn Tyr Lys Leu Gly Gly Asn Tyr Gly Pro Thr Val Leu Val
225                 230                 235                 240 
Gln Gln Glu Ala Leu Lys Arg Gly Cys Glu Gln Val Leu Trp Leu Tyr
                245                 250                 255     
Gly Pro Asp His Gln Leu Thr Glu Val Gly Thr Met Asn Ile Phe Val
            260                 265                 270         
Tyr Trp Thr His Glu Asp Gly Val Leu Glu Leu Val Thr Pro Pro Leu
        275                 280                 285             
Asn Gly Val Ile Leu Pro Gly Val Val Arg Gln Ser Leu Leu Asp Met
    290                 295                 300                 
Ala Gln Thr Trp Gly Glu Phe Arg Val Val Glu Arg Thr Ile Thr Met
305                 310                 315                 320 
Lys Gln Leu Leu Arg Ala Leu Glu Glu Gly Arg Val Arg Glu Val Phe
                325                 330                 335     
Gly Ser Gly Thr Ala Cys Gln Val Cys Pro Val His Arg Ile Leu Tyr
            340                 345                 350         
Lys Asp Arg Asn Leu His Ile Pro Thr Met Glu Asn Gly Pro Glu Leu
        355                 360                 365             
Ile Leu Arg Phe Gln Lys Glu Leu Lys Glu Ile Gln Tyr Gly Ile Arg
    370                 375                 380                 
Ala His Glu Trp Met Phe Pro Val
385                 390         


<210> 1445
<211> 393
<212> PRT
<213> Homo sapiens

<400> 1445
Met Ala Leu Lys Val Ala Thr Val Ala Gly Ser Ala Ala Lys Ala Val
 1               5                  10                  15      
Leu Gly Pro Ala Leu Leu Cys Arg Pro Trp Glu Val Leu Gly Ala His
            20                  25                  30          
Glu Val Pro Ser Arg Asn Ile Phe Ser Glu Gln Thr Ile Pro Pro Ser
        35                  40                  45              
Ala Lys Tyr Gly Gly Arg His Thr Val Thr Met Ile Pro Gly Asp Gly
    50                  55                  60                  
Ile Gly Pro Glu Leu Met Leu His Val Lys Ser Val Phe Arg His Ala
65                  70                  75                  80  
Cys Val Pro Val Asp Phe Glu Glu Val His Val Ser Ser Asn Ala Asp
                85                  90                  95      
Glu Glu Asp Ile Arg Asn Ala Ile Met Ala Ile Arg Arg Asn Arg Val
            100                 105                 110         
Ala Leu Lys Gly Asn Ile Glu Thr Asn His Asn Leu Pro Pro Ser His
        115                 120                 125             
Lys Ser Arg Asn Asn Ile Leu Arg Thr Ser Leu Asp Leu Tyr Ala Asn
    130                 135                 140                 
Val Ile His Cys Lys Ser Leu Pro Gly Val Val Thr Arg His Lys Asp
145                 150                 155                 160 
Ile Asp Ile Leu Ile Val Arg Glu Asn Thr Glu Gly Glu Tyr Ser Ser
                165                 170                 175     
Leu Glu His Glu Ser Val Ala Gly Val Val Glu Ser Leu Lys Ile Ile
            180                 185                 190         
Thr Lys Ala Lys Ser Leu Arg Ile Ala Glu Tyr Ala Phe Lys Leu Ala
        195                 200                 205             
Gln Glu Ser Gly Arg Lys Lys Val Thr Ala Val His Lys Ala Asn Ile
    210                 215                 220                 
Met Lys Leu Gly Asp Gly Leu Phe Leu Gln Cys Cys Arg Glu Val Ala
225                 230                 235                 240 
Ala Arg Tyr Pro Gln Ile Thr Phe Glu Asn Met Ile Val Asp Asn Thr
                245                 250                 255     
Thr Met Gln Leu Val Ser Arg Pro Gln Gln Leu Asp Val Met Val Met
            260                 265                 270         
Pro Asn Leu Tyr Gly Asn Ile Val Asn Asn Val Cys Ala Gly Leu Val
        275                 280                 285             
Gly Gly Pro Gly Leu Val Ala Gly Ala Asn Tyr Gly His Val Tyr Ala
    290                 295                 300                 
Val Phe Glu Thr Ala Thr Arg Asn Thr Gly Lys Ser Ile Ala Asn Lys
305                 310                 315                 320 
Asn Ile Ala Asn Pro Thr Ala Thr Leu Leu Ala Ser Cys Met Met Leu
                325                 330                 335     
Asp His Leu Lys Leu His Ser Tyr Ala Thr Ser Ile Arg Lys Ala Val
            340                 345                 350         
Leu Ala Ser Met Asp Asn Glu Asn Met His Thr Pro Asp Ile Gly Gly
        355                 360                 365             
Gln Gly Thr Thr Ser Glu Ala Ile Gln Asp Val Ile Arg His Ile Arg
    370                 375                 380                 
Val Ile Asn Gly Arg Ala Val Glu Ala
385                 390             


<210> 1446
<211> 415
<212> PRT
<213> Homo sapiens

<400> 1446
Met Leu Trp Ser Gly Cys Arg Arg Phe Gly Ala Arg Leu Gly Cys Leu
 1               5                  10                  15      
Pro Gly Gly Leu Arg Val Leu Val Gln Thr Gly His Arg Ser Leu Thr
            20                  25                  30          
Ser Cys Ile Asp Pro Ser Met Gly Leu Asn Glu Glu Gln Lys Glu Phe
        35                  40                  45              
Gln Lys Val Ala Phe Asp Phe Ala Ala Arg Glu Met Ala Pro Asn Met
    50                  55                  60                  
Ala Glu Trp Asp Gln Lys Glu Leu Phe Pro Val Asp Val Met Arg Lys
65                  70                  75                  80  
Ala Ala Gln Leu Gly Phe Gly Gly Val Tyr Ile Gln Thr Asp Val Gly
                85                  90                  95      
Gly Ser Gly Leu Ser Arg Leu Asp Thr Ser Val Ile Phe Glu Ala Leu
            100                 105                 110         
Ala Thr Gly Cys Thr Ser Thr Thr Ala Tyr Ile Ser Ile His Asn Met
        115                 120                 125             
Cys Ala Trp Met Ile Asp Ser Phe Gly Asn Glu Glu Gln Arg His Lys
    130                 135                 140                 
Phe Cys Pro Pro Leu Cys Thr Met Glu Lys Phe Ala Ser Tyr Cys Leu
145                 150                 155                 160 
Thr Glu Pro Gly Ser Gly Ser Asp Ala Ala Ser Leu Leu Thr Ser Ala
                165                 170                 175     
Lys Lys Gln Gly Asp His Tyr Ile Leu Asn Gly Ser Lys Ala Phe Ile
            180                 185                 190         
Ser Gly Ala Gly Glu Ser Asp Ile Tyr Val Val Met Cys Arg Thr Gly
        195                 200                 205             
Gly Leu Gly Pro Lys Gly Ile Ser Cys Ile Val Val Glu Lys Gly Thr
    210                 215                 220                 
Pro Gly Leu Ser Phe Gly Lys Lys Glu Lys Lys Val Gly Trp Asn Ser
225                 230                 235                 240 
Gln Pro Thr Arg Ala Val Ile Phe Glu Asp Cys Ala Val Pro Val Ala
                245                 250                 255     
Asn Arg Ile Gly Ser Glu Gly Gln Gly Phe Leu Ile Ala Val Arg Gly
            260                 265                 270         
Leu Asn Gly Gly Arg Ile Asn Ile Ala Ser Cys Ser Leu Gly Ala Ala
        275                 280                 285             
His Ala Ser Val Ile Leu Thr Arg Asp His Leu Asn Val Arg Lys Gln
    290                 295                 300                 
Phe Gly Glu Pro Leu Ala Ser Asn Gln Tyr Leu Gln Phe Thr Leu Ala
305                 310                 315                 320 
Asp Met Ala Thr Arg Leu Val Ala Ala Arg Leu Met Val Arg Asn Ala
                325                 330                 335     
Ala Val Ala Leu Gln Glu Glu Arg Lys Asp Ala Val Ala Leu Cys Ser
            340                 345                 350         
Met Ala Lys Leu Phe Ala Thr Asp Glu Cys Phe Ala Ile Cys Asn Gln
        355                 360                 365             
Ala Leu Gln Met His Gly Gly Tyr Gly Tyr Leu Lys Asp Tyr Ala Val
    370                 375                 380                 
Gln Gln Tyr Val Arg Asp Ser Arg Val His Gln Ile Leu Glu Gly Ser
385                 390                 395                 400 
Asn Glu Val Met Arg Ile Leu Ile Ser Arg Ser Leu Leu Gln Glu
                405                 410                 415 


<210> 1447
<211> 494
<212> PRT
<213> Homo sapiens

<400> 1447
Ser Thr Ser Gly Ser Gln Gly His Lys Lys Gly Ala Arg Thr Pro Lys
 1               5                  10                  15      
Val Pro Lys Gln Gly Gly Met Asn Trp Ala Asp Leu Leu Pro Pro Pro
            20                  25                  30          
Pro Ala His Pro Pro Pro His Ser Asn Ser Glu Glu Tyr Asn Ile Ser
        35                  40                  45              
Val Asp Glu Ser Tyr Asp Gln Glu Met Pro Cys Pro Val Pro Pro Ala
    50                  55                  60                  
Arg Met Tyr Leu Gln Gln Asp Glu Leu Glu Glu Glu Glu Asp Glu Arg
65                  70                  75                  80  
Gly Pro Thr Pro Pro Val Arg Gly Ala Ala Ser Ser Pro Ala Ala Val
                85                  90                  95      
Ser Tyr Ser His Gln Ser Thr Ala Thr Leu Thr Pro Ser Pro Gln Glu
            100                 105                 110         
Glu Leu Gln Pro Met Leu Gln Asp Cys Pro Glu Glu Thr Gly His Met
        115                 120                 125             
Gln His Gln Pro Asp Arg Arg Arg Gln Pro Val Ser Pro Pro Pro Pro
    130                 135                 140                 
Pro Arg Pro Ile Ser Pro Pro His Thr Tyr Gly Tyr Ile Ser Gly Pro
145                 150                 155                 160 
Leu Val Ser Asp Met Asp Thr Asp Ala Pro Glu Glu Glu Glu Asp Glu
                165                 170                 175     
Ala Asp Met Glu Val Ala Lys Met Gln Thr Arg Arg Leu Leu Leu Arg
            180                 185                 190         
Gly Leu Glu Gln Thr Pro Ala Ser Ser Val Gly Asp Leu Glu Ser Ser
        195                 200                 205             
Val Thr Gly Ser Met Ile Asn Gly Trp Gly Ser Ala Ser Glu Glu Asp
    210                 215                 220                 
Asn Ile Ser Ser Gly Arg Ser Ser Val Ser Ser Ser Asp Gly Ser Phe
225                 230                 235                 240 
Phe Thr Asp Ala Asp Phe Ala Gln Ala Val Ala Ala Ala Ala Glu Tyr
                245                 250                 255     
Ala Gly Leu Lys Val Ala Arg Arg Gln Met Gln Asp Ala Ala Gly Arg
            260                 265                 270         
Arg His Phe His Ala Ser Gln Cys Pro Arg Pro Thr Ser Pro Val Ser
        275                 280                 285             
Thr Asp Ser Asn Met Ser Ala Ala Val Met Gln Lys Thr Arg Pro Ala
    290                 295                 300                 
Lys Lys Leu Lys His Gln Pro Gly His Leu Arg Arg Glu Thr Tyr Thr
305                 310                 315                 320 
Asp Asp Leu Pro Pro Pro Pro Val Pro Pro Pro Ala Ile Lys Ser Pro
                325                 330                 335     
Thr Ala Gln Ser Lys Thr Gln Leu Glu Val Arg Pro Val Val Val Pro
            340                 345                 350         
Lys Leu Pro Ser Met Asp Ala Arg Thr Asp Arg Ser Ser Asp Arg Lys
        355                 360                 365             
Gly Ser Ser Tyr Lys Gly Arg Glu Val Leu Asp Gly Arg Gln Val Val
    370                 375                 380                 
Asp Met Arg Thr Asn Pro Gly Asp Pro Arg Glu Ala Gln Glu Gln Gln
385                 390                 395                 400 
Asn Asp Gly Lys Gly Arg Gly Asn Lys Ala Ala Lys Arg Asp Leu Pro
                405                 410                 415     
Pro Ala Lys Thr His Leu Ile Gln Glu Asp Ile Leu Pro Tyr Cys Arg
            420                 425                 430         
Pro Thr Phe Pro Thr Ser Asn Asn Pro Arg Asp Pro Ser Ser Ser Ser
        435                 440                 445             
Ser Met Ser Ser Arg Gly Ser Gly Ser Arg Gln Arg Glu Gln Ala Asn
    450                 455                 460                 
Val Gly Arg Arg Asn Ile Ala Glu Met Gln Val Leu Gly Gly Tyr Glu
465                 470                 475                 480 
Arg Gly Glu Asp Asn Asn Glu Glu Leu Glu Glu Thr Glu Ser
                485                 490                 


<210> 1448
<211> 514
<212> PRT
<213> Homo sapiens

<400> 1448
Met Ala Asp Ser Gly Leu Asp Lys Lys Ser Thr Lys Cys Pro Asp Cys
 1               5                  10                  15      
Ser Ser Ala Ser Gln Lys Asp Val Leu Cys Val Cys Ser Ser Lys Thr
            20                  25                  30          
Arg Val Pro Pro Val Leu Val Val Glu Met Ser Gln Thr Ser Ser Ile
        35                  40                  45              
Gly Ser Ala Glu Ser Leu Ile Ser Leu Glu Arg Lys Lys Glu Lys Asn
    50                  55                  60                  
Ile Asn Arg Asp Ile Thr Ser Arg Lys Asp Leu Pro Ser Arg Thr Ser
65                  70                  75                  80  
Asn Val Glu Arg Lys Ala Ser Gln Gln Gln Trp Gly Arg Gly Asn Phe
                85                  90                  95      
Thr Glu Gly Lys Val Pro His Ile Arg Ile Glu Asn Gly Ala Ala Ile
            100                 105                 110         
Glu Glu Ile Tyr Thr Phe Gly Arg Ile Leu Gly Lys Gly Ser Phe Gly
        115                 120                 125             
Ile Val Ile Glu Ala Thr Asp Lys Glu Thr Glu Thr Lys Trp Ala Ile
    130                 135                 140                 
Lys Lys Val Asn Lys Glu Lys Ala Gly Ser Ser Ala Val Lys Leu Leu
145                 150                 155                 160 
Glu Arg Glu Val Asn Ile Leu Lys Ser Val Lys His Glu His Ile Ile
                165                 170                 175     
His Leu Glu Gln Val Phe Glu Thr Pro Lys Lys Met Tyr Leu Val Met
            180                 185                 190         
Glu Leu Cys Glu Asp Gly Glu Leu Lys Glu Ile Leu Asp Arg Lys Gly
        195                 200                 205             
His Phe Ser Glu Asn Glu Thr Arg Trp Ile Ile Gln Ser Leu Ala Ser
    210                 215                 220                 
Ala Ile Ala Tyr Leu His Asn Asn Asp Ile Val His Arg Asp Leu Lys
225                 230                 235                 240 
Leu Glu Asn Ile Met Val Lys Ser Ser Leu Ile Asp Asp Asn Asn Glu
                245                 250                 255     
Ile Asn Leu Asn Ile Lys Val Thr Asp Phe Gly Leu Ala Val Lys Lys
            260                 265                 270         
Gln Ser Arg Ser Glu Ala Met Leu Gln Ala Thr Cys Gly Thr Pro Ile
        275                 280                 285             
Tyr Met Ala Pro Glu Val Ile Ser Ala His Asp Tyr Ser Gln Gln Cys
    290                 295                 300                 
Asp Ile Trp Ser Ile Gly Val Val Met Tyr Met Leu Leu Arg Gly Glu
305                 310                 315                 320 
Pro Pro Phe Leu Ala Ser Ser Glu Glu Lys Leu Phe Glu Leu Ile Arg
                325                 330                 335     
Lys Gly Glu Leu His Phe Glu Asn Ala Val Trp Asn Ser Ile Ser Asp
            340                 345                 350         
Cys Ala Lys Ser Val Leu Lys Gln Leu Met Lys Val Asp Pro Ala His
        355                 360                 365             
Arg Ile Thr Ala Lys Glu Leu Leu Asp Asn Gln Trp Leu Thr Gly Asn
    370                 375                 380                 
Lys Leu Ser Ser Val Arg Pro Thr Asn Val Leu Glu Met Met Lys Glu
385                 390                 395                 400 
Trp Lys Asn Asn Pro Glu Ser Val Glu Glu Asn Thr Thr Glu Glu Lys
                405                 410                 415     
Asn Lys Pro Ser Thr Glu Glu Lys Leu Lys Ser Tyr Gln Pro Trp Gly
            420                 425                 430         
Asn Val Pro Asp Ala Asn Tyr Thr Ser Asp Glu Glu Glu Glu Lys Gln
        435                 440                 445             
Ser Thr Ala Tyr Glu Lys Gln Phe Pro Ala Thr Ser Lys Asp Asn Phe
    450                 455                 460                 
Asp Met Cys Ser Ser Ser Phe Thr Ser Ser Lys Leu Leu Pro Ala Glu
465                 470                 475                 480 
Ile Lys Gly Glu Met Glu Lys Thr Pro Val Thr Pro Ser Gln Gly Thr
                485                 490                 495     
Ala Thr Lys Tyr Pro Ala Lys Ser Gly Ala Leu Ser Arg Thr Lys Lys
            500                 505                 510         
Lys Leu
        


<210> 1449
<211> 1336
<212> PRT
<213> Homo sapiens

<400> 1449
Met Ala Thr Glu Ile Gly Ser Pro Pro Arg Phe Phe His Met Pro Arg
 1               5                  10                  15      
Phe Gln His Gln Ala Pro Arg Gln Leu Phe Tyr Lys Arg Pro Asp Phe
            20                  25                  30          
Ala Gln Gln Gln Ala Met Gln Gln Leu Thr Phe Asp Gly Lys Arg Met
        35                  40                  45              
Arg Lys Ala Val Asn Arg Lys Thr Ile Asp Tyr Asn Pro Ser Val Ile
    50                  55                  60                  
Lys Tyr Leu Glu Asn Arg Ile Trp Gln Arg Asp Gln Arg Asp Met Arg
65                  70                  75                  80  
Ala Ile Gln Pro Asp Ala Gly Tyr Tyr Asn Asp Leu Val Pro Pro Ile
                85                  90                  95      
Gly Met Leu Asn Asn Pro Met Asn Ala Val Thr Thr Lys Phe Val Arg
            100                 105                 110         
Thr Ser Thr Asn Lys Val Lys Cys Pro Val Phe Val Val Arg Trp Thr
        115                 120                 125             
Pro Glu Gly Arg Arg Leu Val Thr Gly Ala Ser Ser Gly Glu Phe Thr
    130                 135                 140                 
Leu Trp Asn Gly Leu Thr Phe Asn Phe Glu Thr Ile Leu Gln Ala His
145                 150                 155                 160 
Asp Ser Pro Val Arg Ala Met Thr Trp Ser His Asn Asp Met Trp Met
                165                 170                 175     
Leu Thr Ala Asp His Gly Gly Tyr Val Lys Tyr Trp Gln Ser Asn Met
            180                 185                 190         
Asn Asn Val Lys Met Phe Gln Ala His Lys Glu Ala Ile Arg Glu Ala
        195                 200                 205             
Ser Phe Ser Pro Thr Asp Asn Lys Phe Ala Thr Cys Ser Asp Asp Gly
    210                 215                 220                 
Thr Val Arg Ile Trp Asp Phe Leu Arg Cys His Glu Glu Arg Ile Leu
225                 230                 235                 240 
Arg Gly His Gly Ala Asp Val Lys Cys Val Asp Trp His Pro Thr Lys
                245                 250                 255     
Gly Leu Val Val Ser Gly Ser Lys Asp Ser Gln Gln Pro Ile Lys Phe
            260                 265                 270         
Trp Asp Pro Lys Thr Gly Gln Ser Leu Ala Thr Leu His Ala His Lys
        275                 280                 285             
Asn Thr Val Met Glu Val Lys Leu Asn Leu Asn Gly Asn Trp Leu Leu
    290                 295                 300                 
Thr Ala Ser Arg Asp His Leu Cys Lys Leu Phe Asp Ile Arg Asn Leu
305                 310                 315                 320 
Lys Glu Glu Leu Gln Val Phe Arg Gly His Lys Lys Glu Ala Thr Ala
                325                 330                 335     
Val Ala Trp His Pro Val His Glu Gly Leu Phe Ala Ser Gly Gly Ser
            340                 345                 350         
Asp Gly Ser Leu Leu Phe Trp His Val Gly Val Glu Lys Glu Val Gly
        355                 360                 365             
Gly Met Glu Met Ala His Glu Gly Met Ile Trp Ser Leu Ala Trp His
    370                 375                 380                 
Pro Leu Gly His Ile Leu Cys Ser Gly Ser Asn Asp His Thr Ser Lys
385                 390                 395                 400 
Phe Trp Thr Arg Asn Arg Pro Gly Asp Lys Met Arg Asp Arg Tyr Asn
                405                 410                 415     
Leu Asn Leu Leu Pro Gly Met Ser Glu Asp Gly Val Glu Tyr Asp Asp
            420                 425                 430         
Leu Glu Pro Asn Ser Leu Ala Val Ile Pro Gly Met Gly Ile Pro Glu
        435                 440                 445             
Gln Leu Lys Leu Ala Met Glu Gln Glu Gln Met Gly Lys Asp Glu Ser
    450                 455                 460                 
Asn Glu Ile Glu Met Thr Ile Pro Gly Leu Asp Trp Gly Met Glu Glu
465                 470                 475                 480 
Val Met Gln Lys Asp Gln Lys Lys Val Pro Gln Lys Lys Val Pro Tyr
                485                 490                 495     
Ala Lys Pro Ile Pro Ala Gln Phe Gln Gln Ala Trp Met Gln Asn Lys
            500                 505                 510         
Val Pro Ile Pro Ala Pro Asn Glu Val Leu Asn Asp Arg Lys Glu Asp
        515                 520                 525             
Ile Lys Leu Glu Glu Lys Lys Lys Thr Gln Ala Glu Ile Glu Gln Glu
    530                 535                 540                 
Met Ala Thr Leu Gln Tyr Thr Asn Pro Gln Leu Leu Glu Gln Leu Lys
545                 550                 555                 560 
Ile Glu Arg Leu Ala Gln Lys Gln Val Glu Gln Ile Gln Pro Pro Pro
                565                 570                 575     
Ser Ser Gly Thr Pro Leu Leu Gly Pro Gln Pro Phe Pro Gly Gln Gly
            580                 585                 590         
Pro Met Ser Gln Ile Pro Gln Gly Phe Gln Gln Pro His Pro Ser Gln
        595                 600                 605             
Gln Met Pro Met Asn Met Ala Gln Met Gly Pro Pro Gly Pro Gln Gly
    610                 615                 620                 
Gln Phe Arg Pro Pro Gly Pro Gln Gly Gln Met Gly Pro Gln Gly Pro
625                 630                 635                 640 
Pro Leu His Gln Gly Gly Gly Gly Pro Gln Gly Phe Met Gly Pro Gln
                645                 650                 655     
Gly Pro Gln Gly Pro Pro Gln Gly Leu Pro Arg Pro Gln Asp Met His
            660                 665                 670         
Gly Pro Gln Gly Met Gln Arg His Pro Gly Pro His Gly Pro Leu Gly
        675                 680                 685             
Pro Gln Gly Pro Pro Gly Pro Gln Gly Ser Ser Gly Pro Gln Gly His
    690                 695                 700                 
Met Gly Pro Gln Gly Pro Pro Gly Pro Gln Ser His Ile Gly Pro Gln
705                 710                 715                 720 
Gly Pro Pro Gly Pro Gln Gly His Leu Gly Pro Gln Gly Pro Pro Gly
                725                 730                 735     
Thr Gln Gly Met Gln Gly Pro Pro Gly Pro Arg Gly Met Gln Gly Pro
            740                 745                 750         
Pro His Pro His Gly Ile Gln Gly Gly Pro Gly Ser Gln Gly Ile Gln
        755                 760                 765             
Gly Pro Val Ser Gln Gly Pro Leu Met Gly Leu Asn Pro Arg Gly Met
    770                 775                 780                 
Gln Gly Pro Pro Gly Pro Arg Glu Asn Gln Gly Pro Ala Pro Gln Gly
785                 790                 795                 800 
Met Ile Met Gly His Pro Pro Gln Glu Met Arg Gly Pro His Pro Pro
                805                 810                 815     
Gly Gly Leu Leu Gly His Gly Pro Gln Glu Met Arg Gly Pro Gln Glu
            820                 825                 830         
Ile Arg Gly Met Gln Gly Pro Pro Pro Gln Gly Ser Met Leu Gly Pro
        835                 840                 845             
Pro Gln Glu Leu Arg Gly Pro Pro Gly Ser Gln Ser Gln Gln Gly Pro
    850                 855                 860                 
Pro Gln Gly Ser Leu Gly Pro Pro Pro Gln Gly Gly Met Gln Gly Pro
865                 870                 875                 880 
Pro Gly Pro Gln Gly Gln Gln Asn Pro Ala Arg Gly Pro His Pro Ser
                885                 890                 895     
Gln Gly Pro Ile Pro Phe Gln Gln Gln Lys Thr Pro Leu Leu Gly Asp
            900                 905                 910         
Gly Pro Arg Ala Pro Phe Asn Gln Glu Gly Gln Ser Thr Gly Pro Pro
        915                 920                 925             
Pro Leu Ile Pro Gly Leu Gly Gln Gln Gly Ala Gln Gly Arg Ile Pro
    930                 935                 940                 
Pro Leu Asn Pro Gly Gln Gly Pro Gly Pro Asn Lys Gly Asp Ser Arg
945                 950                 955                 960 
Gly Pro Pro Asn His His Met Gly Pro Met Ser Glu Arg Arg His Glu
                965                 970                 975     
Gln Ser Gly Gly Pro Glu His Gly Pro Glu Arg Gly Pro Phe Arg Gly
            980                 985                 990         
Gly Gln Asp Cys Arg Gly Pro Pro Asp Arg Arg Gly Pro His Pro Asp
        995                 1000                1005            
Phe Pro Asp Asp Phe Ser Arg Pro Asp Asp Phe His Pro Asp Lys Arg
    1010                1015                1020                
Phe Gly His Arg Leu Arg Glu Phe Glu Gly Arg Gly Gly Pro Leu Pro
1025                1030                1035                1040
Gln Glu Glu Lys Trp Arg Arg Gly Gly Pro Gly Pro Pro Phe Pro Pro
                1045                1050                1055    
Asp His Arg Glu Phe Ser Glu Gly Asp Gly Arg Gly Ala Ala Arg Gly
            1060                1065                1070        
Pro Pro Gly Ala Trp Glu Gly Arg Arg Pro Gly Asp Glu Arg Phe Pro
        1075                1080                1085            
Arg Asp Pro Glu Asp Pro Arg Phe Arg Gly Arg Arg Glu Glu Ser Phe
    1090                1095                1100                
Arg Arg Gly Ala Pro Pro Arg His Glu Gly Arg Ala Pro Pro Arg Gly
1105                1110                1115                1120
Arg Asp Gly Phe Pro Gly Pro Glu Asp Phe Gly Pro Glu Glu Asn Phe
                1125                1130                1135    
Asp Ala Ser Glu Glu Ala Ala Arg Gly Arg Asp Leu Arg Gly Arg Gly
            1140                1145                1150        
Arg Gly Thr Pro Arg Gly Gly Arg Lys Gly Leu Leu Pro Thr Pro Asp
        1155                1160                1165            
Glu Phe Pro Arg Phe Glu Gly Gly Arg Lys Pro Asp Ser Trp Asp Gly
    1170                1175                1180                
Asn Arg Glu Pro Gly Pro Gly His Glu His Phe Arg Asp Thr Pro Arg
1185                1190                1195                1200
Pro Asp His Pro Pro His Asp Gly His Ser Pro Ala Ser Arg Glu Arg
                1205                1210                1215    
Ser Ser Ser Leu Gln Gly Met Asp Met Ala Ser Leu Pro Pro Arg Lys
            1220                1225                1230        
Arg Pro Trp His Asp Gly Pro Gly Thr Ser Glu His Arg Glu Met Glu
        1235                1240                1245            
Ala Pro Gly Gly Pro Ser Glu Asp Arg Gly Gly Lys Gly Arg Gly Gly
    1250                1255                1260                
Pro Gly Pro Ala Gln Arg Val Pro Lys Ser Gly Arg Ser Ser Ser Leu
1265                1270                1275                1280
Asp Gly Glu His His Asp Gly Tyr His Arg Asp Glu Pro Phe Gly Gly
                1285                1290                1295    
Pro Pro Gly Ser Gly Thr Pro Ser Arg Gly Gly Arg Ser Gly Ser Asn
            1300                1305                1310        
Trp Gly Arg Gly Ser Asn Met Asn Ser Gly Pro Pro Arg Arg Gly Ala
        1315                1320                1325            
Ser Arg Gly Gly Gly Arg Gly Arg
    1330                1335    


<210> 1450
<211> 442
<212> PRT
<213> Homo sapiens

<400> 1450
Met Gly Leu Ala Met Glu His Gly Gly Ser Tyr Ala Arg Ala Gly Gly
 1               5                  10                  15      
Ser Ser Arg Gly Cys Trp Tyr Tyr Leu Arg Tyr Phe Phe Leu Phe Val
            20                  25                  30          
Ser Leu Ile Gln Phe Leu Ile Ile Leu Gly Leu Val Leu Phe Met Val
        35                  40                  45              
Tyr Gly Asn Val His Val Ser Thr Glu Ser Asn Leu Gln Ala Thr Glu
    50                  55                  60                  
Arg Arg Ala Glu Gly Leu Tyr Ser Gln Leu Leu Gly Leu Thr Ala Ser
65                  70                  75                  80  
Gln Ser Asn Leu Thr Lys Glu Leu Asn Phe Thr Thr Arg Ala Lys Asp
                85                  90                  95      
Ala Ile Met Gln Met Trp Leu Asn Ala Arg Arg Asp Leu Asp Arg Ile
            100                 105                 110         
Asn Ala Ser Phe Arg Gln Cys Gln Gly Asp Arg Val Ile Tyr Thr Asn
        115                 120                 125             
Asn His Arg Tyr Met Ala Ala Ile Ile Leu Ser Glu Lys Gln Cys Arg
    130                 135                 140                 
Asp Gln Phe Lys Asp Met Asn Lys Ser Cys Asp Ala Leu Leu Phe Met
145                 150                 155                 160 
Leu Asn Gln Lys Val Lys Thr Leu Glu Val Glu Ile Ala Lys Glu Lys
                165                 170                 175     
Thr Ile Cys Thr Lys Asp Lys Glu Ser Val Leu Leu Asn Lys Arg Val
            180                 185                 190         
Ala Glu Glu Gln Leu Val Glu Cys Val Lys Thr Arg Glu Leu Gln His
        195                 200                 205             
Gln Glu Arg Gln Leu Ala Lys Glu Gln Leu Gln Lys Val Gln Ala Leu
    210                 215                 220                 
Cys Leu Pro Leu Asp Lys Asp Lys Phe Glu Met Asp Leu Arg Asn Leu
225                 230                 235                 240 
Trp Arg Asp Ser Ile Ile Pro Arg Ser Leu Asp Asn Leu Gly Tyr Asn
                245                 250                 255     
Leu Tyr His Pro Leu Gly Ser Glu Leu Ala Ser Ile Arg Arg Ala Cys
            260                 265                 270         
Asp His Met Pro Ser Leu Met Ser Ser Lys Val Glu Glu Leu Ala Arg
        275                 280                 285             
Ser Leu Arg Ala Asp Ile Glu Arg Val Ala Arg Glu Asn Ser Asp Leu
    290                 295                 300                 
Gln Arg Gln Lys Leu Glu Ala Gln Gln Gly Leu Arg Ala Ser Gln Glu
305                 310                 315                 320 
Ala Lys Gln Lys Val Glu Lys Glu Ala Gln Ala Arg Glu Ala Lys Leu
                325                 330                 335     
Gln Ala Glu Cys Ser Arg Gln Thr Gln Leu Ala Leu Glu Glu Lys Ala
            340                 345                 350         
Val Leu Arg Lys Glu Arg Asp Asn Leu Ala Lys Glu Leu Glu Glu Lys
        355                 360                 365             
Lys Arg Glu Ala Glu Gln Leu Arg Met Glu Leu Ala Ile Arg Asn Ser
    370                 375                 380                 
Ala Leu Asp Thr Cys Ile Lys Thr Lys Ser Gln Pro Met Met Pro Val
385                 390                 395                 400 
Ser Arg Pro Met Gly Pro Val Pro Asn Pro Gln Pro Ile Asp Pro Ala
                405                 410                 415     
Ser Leu Glu Glu Phe Lys Arg Lys Ile Leu Glu Ser Gln Arg Pro Pro
            420                 425                 430         
Ala Gly Ile Pro Val Ala Pro Ser Ser Gly
        435                 440         


<210> 1451
<211> 218
<212> PRT
<213> Homo sapiens

<400> 1451
Met Ala Arg Lys Lys Val Arg Pro Arg Leu Ile Ala Glu Leu Ala Arg
 1               5                  10                  15      
Arg Val Arg Ala Leu Arg Glu Gln Leu Asn Arg Pro Arg Asp Ser Gln
            20                  25                  30          
Leu Tyr Ala Val Asp Tyr Glu Thr Leu Thr Arg Pro Phe Ser Gly Arg
        35                  40                  45              
Arg Leu Pro Val Arg Ala Trp Ala Asp Val Arg Arg Glu Ser Arg Leu
    50                  55                  60                  
Leu Gln Leu Leu Gly Arg Leu Pro Leu Phe Gly Leu Gly Arg Leu Val
65                  70                  75                  80  
Thr Arg Lys Ser Trp Leu Trp Gln His Asp Glu Pro Cys Tyr Trp Arg
                85                  90                  95      
Leu Thr Arg Val Arg Pro Asp Tyr Thr Ala Gln Asn Leu Asp His Gly
            100                 105                 110         
Lys Ala Trp Gly Ile Leu Thr Phe Lys Gly Lys Thr Glu Ser Glu Ala
        115                 120                 125             
Arg Glu Ile Glu His Val Met Tyr His Asp Trp Arg Leu Val Pro Lys
    130                 135                 140                 
His Glu Glu Glu Ala Phe Thr Ala Phe Thr Pro Ala Pro Glu Asp Ser
145                 150                 155                 160 
Leu Ala Ser Val Pro Tyr Pro Pro Leu Leu Arg Ala Met Ile Ile Ala
                165                 170                 175     
Glu Arg Gln Lys Asn Gly Asp Thr Ser Thr Glu Glu Pro Met Leu Asn
            180                 185                 190         
Val Gln Arg Ile Arg Met Glu Pro Trp Asp Tyr Pro Ala Lys Gln Glu
        195                 200                 205             
Asp Lys Gly Arg Ala Lys Gly Thr Pro Val
    210                 215             


<210> 1452
<211> 601
<212> PRT
<213> Homo sapiens

<400> 1452
Met Pro Glu Arg Glu Leu Trp Pro Ala Gly Thr Gly Ser Glu Pro Val
 1               5                  10                  15      
Thr Arg Val Gly Ser Cys Asp Ser Met Met Ser Ser Thr Ser Thr Arg
            20                  25                  30          
Ser Gly Ser Ser Asp Ser Ser Tyr Asp Phe Leu Ser Thr Glu Glu Lys
        35                  40                  45              
Glu Cys Leu Leu Phe Leu Glu Glu Thr Ile Gly Ser Leu Asp Thr Glu
    50                  55                  60                  
Ala Asp Ser Gly Leu Ser Thr Asp Glu Ser Glu Pro Ala Thr Thr Pro
65                  70                  75                  80  
Arg Gly Phe Arg Ala Leu Pro Ile Thr Gln Pro Thr Pro Arg Gly Gly
                85                  90                  95      
Pro Glu Glu Thr Ile Thr Gln Gln Gly Arg Thr Pro Arg Thr Val Thr
            100                 105                 110         
Glu Ser Ser Ser Ser His Pro Pro Glu Pro Gln Gly Leu Gly Leu Arg
        115                 120                 125             
Ser Gly Ser Tyr Ser Leu Pro Arg Asn Ile His Ile Ala Arg Ser Gln
    130                 135                 140                 
Asn Phe Arg Lys Ser Thr Thr Gln Ala Ser Ser His Asn Pro Gly Glu
145                 150                 155                 160 
Pro Gly Arg Leu Ala Pro Glu Pro Glu Lys Glu Gln Val Ser Gln Ser
                165                 170                 175     
Ser Gln Pro Arg Gln Ala Pro Ala Ser Pro Gln Glu Ala Ala Leu Asp
            180                 185                 190         
Leu Asp Val Val Leu Ile Pro Pro Pro Glu Ala Phe Arg Asp Thr Gln
        195                 200                 205             
Pro Glu Gln Cys Arg Glu Ala Ser Leu Pro Glu Gly Pro Gly Gln Gln
    210                 215                 220                 
Gly His Thr Pro Gln Leu His Thr Pro Ser Ser Ser Gln Glu Arg Glu
225                 230                 235                 240 
Gln Thr Pro Ser Glu Ala Met Ser Gln Lys Ala Lys Glu Thr Val Ser
                245                 250                 255     
Thr Arg Tyr Thr Gln Pro Gln Pro Pro Pro Ala Gly Leu Pro Gln Asn
            260                 265                 270         
Ala Arg Ala Glu Asp Ala Pro Leu Ser Ser Gly Glu Asp Pro Asn Ser
        275                 280                 285             
Arg Leu Ala Pro Leu Thr Thr Pro Lys Pro Arg Lys Leu Pro Pro Asn
    290                 295                 300                 
Ile Val Leu Lys Ser Ser Arg Ser Ser Phe His Ser Asp Pro Gln His
305                 310                 315                 320 
Trp Leu Ser Arg His Thr Glu Ala Ala Pro Gly Asp Ser Gly Leu Ile
                325                 330                 335     
Ser Cys Ser Leu Gln Glu Gln Arg Lys Ala Arg Lys Glu Ala Leu Glu
            340                 345                 350         
Lys Leu Gly Leu Pro Gln Asp Gln Asp Glu Pro Gly Leu His Leu Ser
        355                 360                 365             
Lys Pro Thr Ser Ser Ile Arg Pro Lys Glu Thr Arg Ala Gln His Leu
    370                 375                 380                 
Ser Pro Ala Pro Gly Leu Ala Gln Pro Ala Ala Pro Ala Gln Ala Ser
385                 390                 395                 400 
Ala Ala Ile Pro Ala Ala Gly Lys Ala Leu Ala Gln Ala Pro Ala Pro
                405                 410                 415     
Ala Pro Gly Pro Ala Gln Gly Pro Leu Pro Met Lys Ser Pro Ala Pro
            420                 425                 430         
Gly Asn Val Ala Ala Ser Lys Ser Met Pro Ile Pro Ile Pro Lys Ala
        435                 440                 445             
Pro Arg Ala Asn Ser Ala Leu Thr Pro Pro Lys Pro Glu Ser Gly Leu
    450                 455                 460                 
Thr Leu Gln Glu Ser Asn Thr Pro Gly Leu Arg Gln Met Asn Phe Lys
465                 470                 475                 480 
Ser Asn Thr Leu Glu Arg Ser Gly Val Gly Leu Ser Ser Tyr Leu Ser
                485                 490                 495     
Thr Glu Lys Asp Ala Ser Pro Lys Thr Ser Thr Ser Leu Gly Lys Gly
            500                 505                 510         
Ser Phe Leu Asp Lys Ile Ser Pro Ser Val Leu Arg Asn Ser Arg Pro
        515                 520                 525             
Arg Pro Ala Ser Leu Gly Thr Gly Lys Asp Phe Ala Gly Ile Gln Val
    530                 535                 540                 
Gly Lys Leu Ala Asp Leu Glu Gln Glu Gln Ser Ser Lys Arg Leu Ser
545                 550                 555                 560 
Tyr Gln Gly Gln Ser Arg Asp Lys Leu Pro Arg Pro Pro Cys Val Ser
                565                 570                 575     
Val Lys Ile Ser Pro Lys Gly Val Pro Asn Glu His Arg Arg Glu Ala
            580                 585                 590         
Leu Lys Lys Leu Gly Leu Leu Lys Glu
        595                 600     


<210> 1453
<211> 926
<212> PRT
<213> Homo sapiens

<400> 1453
Met Leu Gln Val His Arg Thr Gly Leu Gly Arg Leu Gly Val Ser Leu
 1               5                  10                  15      
Ser Lys Gly Leu His His Lys Ala Val Leu Ala Val Arg Arg Glu Asp
            20                  25                  30          
Val Asn Ala Trp Glu Arg Arg Ala Pro Leu Ala Pro Lys His Ile Lys
        35                  40                  45              
Gly Ile Thr Asn Leu Gly Tyr Lys Val Leu Ile Gln Pro Ser Asn Arg
    50                  55                  60                  
Arg Ala Ile His Asp Lys Asp Tyr Val Lys Ala Gly Gly Ile Leu Gln
65                  70                  75                  80  
Glu Asp Ile Ser Glu Ala Cys Leu Ile Leu Gly Val Lys Arg Pro Pro
                85                  90                  95      
Glu Glu Lys Leu Met Ser Arg Lys Thr Tyr Ala Phe Phe Ser His Thr
            100                 105                 110         
Ile Lys Ala Gln Glu Ala Asn Met Gly Leu Leu Asp Glu Ile Leu Lys
        115                 120                 125             
Gln Glu Ile Arg Leu Ile Asp Tyr Glu Lys Met Val Asp His Arg Gly
    130                 135                 140                 
Val Arg Val Val Ala Phe Gly Gln Trp Ala Gly Val Ala Gly Met Ile
145                 150                 155                 160 
Asn Ile Leu His Gly Met Gly Leu Arg Leu Leu Ala Leu Gly His His
                165                 170                 175     
Thr Pro Phe Met His Ile Gly Met Ala His Asn Tyr Arg Asn Ser Ser
            180                 185                 190         
Gln Ala Val Gln Ala Val Arg Asp Ala Gly Tyr Glu Ile Ser Leu Gly
        195                 200                 205             
Leu Met Pro Lys Ser Ile Gly Pro Leu Thr Phe Val Phe Thr Gly Thr
    210                 215                 220                 
Gly Asn Val Ser Lys Gly Ala Gln Ala Ile Phe Asn Glu Leu Pro Cys
225                 230                 235                 240 
Glu Tyr Val Glu Pro His Glu Leu Lys Glu Val Ser Gln Thr Gly Asp
                245                 250                 255     
Leu Arg Lys Val Tyr Gly Thr Val Leu Ser Arg His His His Leu Val
            260                 265                 270         
Arg Lys Thr Asp Ala Val Tyr Asp Pro Ala Glu Tyr Asp Lys His Pro
        275                 280                 285             
Glu Arg Tyr Ile Ser Arg Phe Asn Thr Asp Ile Ala Pro Tyr Thr Thr
    290                 295                 300                 
Cys Leu Ile Asn Gly Ile Tyr Trp Glu Gln Asn Thr Pro Arg Leu Leu
305                 310                 315                 320 
Thr Arg Gln Asp Ala Gln Ser Leu Leu Ala Pro Gly Lys Phe Ser Pro
                325                 330                 335     
Ala Gly Val Glu Gly Cys Pro Ala Leu Pro His Lys Leu Val Ala Ile
            340                 345                 350         
Cys Asp Ile Ser Ala Asp Thr Gly Gly Ser Ile Glu Phe Met Thr Glu
        355                 360                 365             
Cys Thr Thr Ile Glu His Pro Phe Cys Met Tyr Asp Ala Asp Gln His
    370                 375                 380                 
Ile Ile His Asp Ser Val Glu Gly Ser Gly Ile Leu Met Cys Ser Ile
385                 390                 395                 400 
Asp Asn Leu Pro Ala Gln Leu Pro Ile Glu Ala Thr Glu Cys Phe Gly
                405                 410                 415     
Asp Met Leu Tyr Pro Tyr Val Glu Glu Met Ile Leu Ser Asp Ala Thr
            420                 425                 430         
Gln Pro Leu Glu Ser Gln Asn Phe Ser Pro Val Val Arg Asp Ala Val
        435                 440                 445             
Ile Thr Ser Asn Gly Thr Leu Pro Asp Lys Tyr Lys Tyr Ile Gln Thr
    450                 455                 460                 
Leu Arg Glu Ser Arg Glu Arg Ala Gln Ser Leu Ser Met Gly Thr Arg
465                 470                 475                 480 
Arg Lys Val Leu Val Leu Gly Ser Gly Tyr Ile Ser Glu Pro Val Leu
                485                 490                 495     
Glu Tyr Leu Ser Arg Asp Gly Asn Ile Glu Ile Thr Val Gly Ser Asp
            500                 505                 510         
Met Lys Asn Gln Ile Glu Gln Leu Gly Lys Lys Tyr Asn Ile Asn Pro
        515                 520                 525             
Val Ser Met Asp Ile Cys Lys Gln Glu Glu Lys Leu Gly Phe Leu Val
    530                 535                 540                 
Ala Lys Gln Asp Leu Val Ile Ser Leu Leu Pro Tyr Val Leu His Pro
545                 550                 555                 560 
Leu Val Ala Lys Ala Cys Ile Thr Asn Lys Val Asn Met Val Thr Ala
                565                 570                 575     
Ser Tyr Ile Thr Pro Ala Leu Lys Glu Leu Glu Lys Ser Val Glu Asp
            580                 585                 590         
Ala Gly Ile Thr Ile Ile Gly Glu Leu Gly Leu Asp Pro Gly Leu Asp
        595                 600                 605             
His Met Leu Ala Met Glu Thr Ile Asp Lys Ala Lys Glu Val Gly Ala
    610                 615                 620                 
Thr Ile Glu Ser Tyr Ile Ser Tyr Cys Gly Gly Leu Pro Ala Pro Glu
625                 630                 635                 640 
His Ser Asn Asn Pro Leu Arg Tyr Lys Phe Ser Trp Ser Pro Val Gly
                645                 650                 655     
Val Leu Met Asn Val Met Gln Ser Ala Thr Tyr Leu Leu Asp Gly Lys
            660                 665                 670         
Val Val Asn Val Ala Gly Gly Ile Ser Phe Leu Asp Ala Val Thr Ser
        675                 680                 685             
Met Asp Phe Phe Pro Gly Leu Asn Leu Glu Gly Tyr Pro Asn Arg Asp
    690                 695                 700                 
Ser Thr Lys Tyr Ala Glu Ile Tyr Gly Ile Ser Ser Ala His Thr Leu
705                 710                 715                 720 
Leu Arg Gly Thr Leu Arg Tyr Lys Gly Tyr Met Lys Ala Leu Asn Gly
                725                 730                 735     
Phe Val Lys Leu Gly Leu Ile Asn Arg Glu Ala Leu Pro Ala Phe Arg
            740                 745                 750         
Pro Glu Ala Asn Pro Leu Thr Trp Lys Gln Leu Leu Cys Asp Leu Val
        755                 760                 765             
Gly Ile Ser Pro Ser Ser Glu His Asp Val Leu Lys Glu Ala Val Leu
    770                 775                 780                 
Lys Lys Leu Gly Gly Asp Asn Thr Gln Leu Glu Ala Ala Glu Trp Leu
785                 790                 795                 800 
Gly Leu Leu Gly Asp Glu Gln Val Pro Gln Ala Glu Ser Ile Leu Asp
                805                 810                 815     
Ala Leu Ser Lys His Leu Val Met Lys Leu Ser Tyr Gly Pro Glu Glu
            820                 825                 830         
Lys Asp Met Ile Val Met Arg Asp Ser Phe Gly Ile Arg His Pro Ser
        835                 840                 845             
Gly His Leu Glu His Lys Thr Ile Asp Leu Val Ala Tyr Gly Asp Ile
    850                 855                 860                 
Asn Gly Phe Ser Ala Met Ala Lys Thr Val Gly Leu Pro Thr Ala Met
865                 870                 875                 880 
Ala Ala Lys Met Leu Leu Asp Gly Glu Ile Gly Ala Lys Gly Leu Met
                885                 890                 895     
Gly Pro Phe Ser Lys Glu Ile Tyr Gly Pro Ile Leu Glu Arg Ile Lys
            900                 905                 910         
Ala Glu Gly Ile Ile Tyr Thr Thr Gln Ser Thr Ile Lys Pro
        915                 920                 925     


<210> 1454
<211> 187
<212> PRT
<213> Homo sapiens

<400> 1454
Met Asn Gly Arg Ala Asp Phe Arg Glu Pro Asn Ala Glu Val Pro Arg
 1               5                  10                  15      
Pro Ile Pro His Ile Gly Pro Asp Tyr Ile Pro Thr Glu Glu Glu Arg
            20                  25                  30          
Arg Val Phe Ala Glu Cys Asn Asp Glu Ser Phe Trp Phe Arg Ser Val
        35                  40                  45              
Pro Leu Ala Ala Thr Ser Met Leu Ile Thr Gln Gly Leu Ile Ser Lys
    50                  55                  60                  
Gly Ile Leu Ser Ser His Pro Lys Tyr Gly Ser Ile Pro Lys Leu Ile
65                  70                  75                  80  
Leu Ala Cys Ile Met Gly Tyr Phe Ala Gly Lys Leu Ser Tyr Val Lys
                85                  90                  95      
Thr Cys Gln Glu Lys Phe Lys Lys Leu Glu Asn Ser Pro Leu Gly Glu
            100                 105                 110         
Ala Leu Arg Ser Gly Gln Ala Arg Arg Ser Ser Pro Pro Gly His Tyr
        115                 120                 125             
Tyr Gln Lys Ser Lys Tyr Asp Ser Ser Val Ser Gly Gln Ser Ser Phe
    130                 135                 140                 
Val Thr Ser Pro Ala Ala Asp Asn Ile Glu Met Leu Pro His Tyr Glu
145                 150                 155                 160 
Pro Ile Pro Phe Ser Ser Ser Met Asn Glu Ser Ala Pro Thr Gly Ile
                165                 170                 175     
Thr Asp His Ile Val Gln Gly Arg Asn Phe Ser
            180                 185         


<210> 1455
<211> 162
<212> PRT
<213> Homo sapiens

<400> 1455
Ala Val Pro Ile Ala Gln Lys Ser Glu Pro His Ser Leu Ser Ser Glu
 1               5                  10                  15      
Ala Leu Met Arg Arg Ala Val Ser Leu Val Thr Asp Ser Thr Ser Thr
            20                  25                  30          
Asp Leu Ser Gln Thr Thr Tyr Ala Leu Ile Glu Ala Ile Thr Glu Tyr
        35                  40                  45              
Thr Lys Ala Val Tyr Thr Leu Thr Ser Leu Tyr Arg Gln Tyr Thr Ser
    50                  55                  60                  
Leu Leu Gly Lys Met Asn Ser Glu Glu Glu Asp Glu Val Trp Gln Val
65                  70                  75                  80  
Ile Ile Gly Ala Arg Ala Glu Met Thr Ser Lys His Gln Glu Tyr Leu
                85                  90                  95      
Lys Leu Glu Thr Thr Trp Met Thr Ala Val Gly Leu Ser Glu Met Ala
            100                 105                 110         
Ala Glu Ala Ala Tyr Gln Thr Gly Ala Asp Gln Ala Ser Ile Thr Ala
        115                 120                 125             
Arg Asn His Ile Gln Leu Val Lys Leu Gln Val Glu Glu Val His Gln
    130                 135                 140                 
Leu Ser Arg Lys Ala Glu Thr Lys Leu Ala Glu Ala Gln Ile Glu Glu
145                 150                 155                 160 
Leu Arg
        


<210> 1456
<211> 965
<212> PRT
<213> Homo sapiens

<400> 1456
Ser Glu Glu Ser Gln Ala Phe Gln Arg Gln Leu Thr Ala Leu Ile Gly
 1               5                  10                  15      
Tyr Asp Val Thr Asp Val Ser Asn Val His Asp Asp Glu Leu Glu Phe
            20                  25                  30          
Thr Arg Arg Gly Leu Val Thr Pro Arg Met Ala Glu Val Ala Ser Arg
        35                  40                  45              
Asp Pro Lys Leu Tyr Ala Met His Pro Trp Val Thr Ser Lys Pro Leu
    50                  55                  60                  
Pro Glu Tyr Leu Trp Lys Lys Ile Ala Asn Asn Cys Ile Phe Ile Lys
65                  70                  75                  80  
Ile His Arg Ser Thr Thr Ser Gln Thr Ile Lys Val Ser Pro Asp Asp
                85                  90                  95      
Thr Pro Gly Ala Ile Leu Gln Ser Phe Phe Thr Lys Met Ala Lys Lys
            100                 105                 110         
Lys Ser Leu Met Asp Ile Pro Glu Ser Gln Ser Glu Gln Asp Phe Val
        115                 120                 125             
Leu Arg Val Cys Gly Arg Asp Glu Tyr Leu Val Gly Glu Thr Pro Ile
    130                 135                 140                 
Lys Asn Phe Gln Trp Val Arg His Cys Leu Lys Asn Gly Glu Glu Ile
145                 150                 155                 160 
His Val Val Leu Asp Thr Pro Pro Asp Pro Ala Leu Asp Glu Val Arg
                165                 170                 175     
Lys Glu Glu Trp Pro Leu Ala Asp Asp Cys Thr Gly Val Thr Gly Tyr
            180                 185                 190         
His Glu Gln Leu Thr Ile His Gly Lys Asp His Glu Ser Val Phe Thr
        195                 200                 205             
Val Ser Leu Trp Asp Cys Asp Arg Lys Phe Arg Val Lys Ile Arg Gly
    210                 215                 220                 
Ile Asp Ile Pro Val Leu Pro Arg Asn Thr Asp Leu Thr Val Phe Val
225                 230                 235                 240 
Glu Ala Asn Ile Gln His Gly Gln Gln Val Leu Cys Gln Arg Arg Thr
                245                 250                 255     
Ser Pro Lys Pro Phe Thr Glu Glu Val Leu Trp Asn Val Trp Leu Glu
            260                 265                 270         
Phe Ser Ile Lys Ile Lys Asp Leu Pro Lys Gly Ala Leu Leu Asn Leu
        275                 280                 285             
Gln Ile Tyr Cys Gly Lys Ala Pro Ala Leu Ser Ser Lys Ala Ser Ala
    290                 295                 300                 
Glu Ser Pro Ser Ser Glu Ser Lys Gly Lys Val Arg Leu Leu Tyr Tyr
305                 310                 315                 320 
Val Asn Leu Leu Leu Ile Asp His Arg Phe Leu Leu Arg Arg Gly Glu
                325                 330                 335     
Tyr Val Leu His Met Trp Gln Ile Ser Gly Lys Gly Glu Asp Gln Gly
            340                 345                 350         
Ser Phe Asn Ala Asp Lys Leu Thr Ser Ala Thr Asn Pro Asp Lys Glu
        355                 360                 365             
Asn Ser Met Ser Ile Ser Ile Leu Leu Asp Asn Tyr Cys His Pro Ile
    370                 375                 380                 
Ala Leu Pro Lys His Gln Pro Thr Pro Asp Pro Glu Gly Asp Arg Val
385                 390                 395                 400 
Arg Ala Glu Met Pro Asn Gln Leu Arg Lys Gln Leu Glu Ala Ile Ile
                405                 410                 415     
Ala Thr Asp Pro Leu Asn Pro Leu Thr Ala Glu Asp Lys Glu Leu Leu
            420                 425                 430         
Trp His Phe Arg Tyr Glu Ser Leu Lys His Pro Lys Ala Tyr Pro Lys
        435                 440                 445             
Leu Phe Ser Ser Val Lys Trp Gly Gln Gln Glu Ile Val Ala Lys Thr
    450                 455                 460                 
Tyr Gln Leu Leu Ala Arg Arg Glu Val Trp Asp Gln Ser Ala Leu Asp
465                 470                 475                 480 
Val Gly Leu Thr Met Gln Leu Leu Asp Cys Asn Phe Ser Asp Glu Asn
                485                 490                 495     
Val Arg Ala Ile Ala Val Gln Lys Leu Glu Ser Leu Glu Asp Asp Asp
            500                 505                 510         
Val Leu His Tyr Leu Leu Gln Leu Val Gln Ala Val Lys Phe Glu Pro
        515                 520                 525             
Tyr His Asp Ser Ala Leu Ala Arg Phe Leu Leu Lys Arg Gly Leu Arg
    530                 535                 540                 
Asn Lys Arg Ile Gly His Phe Leu Phe Trp Phe Leu Arg Ser Glu Ile
545                 550                 555                 560 
Ala Gln Ser Arg His Tyr Gln Gln Arg Phe Ala Val Ile Leu Glu Ala
                565                 570                 575     
Tyr Leu Arg Gly Cys Gly Thr Ala Met Leu His Asp Phe Thr Gln Gln
            580                 585                 590         
Val Gln Val Ile Glu Met Leu Gln Lys Val Thr Leu Asp Ile Lys Ser
        595                 600                 605             
Leu Ser Ala Glu Lys Tyr Asp Val Ser Ser Gln Val Ile Ser Gln Leu
    610                 615                 620                 
Lys Gln Lys Leu Glu Asn Leu Gln Asn Ser Gln Leu Pro Glu Ser Phe
625                 630                 635                 640 
Arg Val Pro Tyr Asp Pro Gly Leu Lys Ala Gly Ala Leu Ala Ile Glu
                645                 650                 655     
Lys Cys Lys Val Met Ala Ser Lys Lys Lys Pro Leu Trp Leu Glu Phe
            660                 665                 670         
Lys Cys Ala Asp Pro Thr Ala Leu Ser Asn Glu Thr Ile Gly Ile Ile
        675                 680                 685             
Phe Lys His Gly Asp Asp Leu Arg Gln Asp Met Leu Ile Leu Gln Ile
    690                 695                 700                 
Leu Arg Ile Met Glu Ser Ile Trp Glu Thr Glu Ser Leu Asp Leu Cys
705                 710                 715                 720 
Leu Leu Pro Tyr Gly Cys Ile Ser Thr Gly Asp Lys Ile Gly Met Ile
                725                 730                 735     
Glu Ile Val Lys Asp Ala Thr Thr Ile Ala Lys Ile Gln Gln Ser Thr
            740                 745                 750         
Val Gly Asn Thr Gly Ala Phe Lys Asp Glu Val Leu Asn His Trp Leu
        755                 760                 765             
Lys Glu Lys Ser Pro Thr Glu Glu Lys Phe Gln Ala Ala Val Glu Arg
    770                 775                 780                 
Phe Val Tyr Ser Cys Ala Gly Tyr Cys Val Ala Thr Phe Val Leu Gly
785                 790                 795                 800 
Ile Gly Asp Arg His Asn Asp Asn Ile Met Ile Thr Glu Thr Gly Asn
                805                 810                 815     
Leu Phe His Ile Asp Phe Gly His Ile Leu Gly Asn Tyr Lys Ser Phe
            820                 825                 830         
Leu Gly Ile Asn Lys Glu Arg Val Pro Phe Val Leu Thr Pro Asp Phe
        835                 840                 845             
Leu Phe Val Met Gly Thr Ser Gly Lys Lys Thr Ser Pro His Phe Gln
    850                 855                 860                 
Lys Phe Gln Asp Ile Cys Val Lys Ala Tyr Leu Ala Leu Arg His His
865                 870                 875                 880 
Thr Asn Leu Leu Ile Ile Leu Phe Ser Met Met Leu Met Thr Gly Met
                885                 890                 895     
Pro Gln Leu Thr Ser Lys Glu Asp Ile Glu Tyr Ile Arg Asp Ala Leu
            900                 905                 910         
Thr Val Gly Lys Asn Glu Glu Asp Ala Lys Lys Tyr Phe Leu Asp Gln
        915                 920                 925             
Ile Glu Val Cys Arg Asp Lys Gly Trp Thr Val Gln Phe Asn Trp Phe
    930                 935                 940                 
Leu His Leu Val Leu Gly Ile Lys Gln Gly Glu Lys His Ser Ala His
945                 950                 955                 960 
His His His His His
                965 


<210> 1457
<211> 338
<212> PRT
<213> Homo sapiens

<400> 1457
Leu Met Pro His Gly Lys Gly Gly Arg Ser Ser Val Ser Gly Ile Val
 1               5                  10                  15      
Ala Thr Val Phe Gly Ala Thr Gly Phe Leu Gly Arg Tyr Val Val Asn
            20                  25                  30          
His Leu Gly Arg Met Gly Ser Gln Val Ile Ile Pro Tyr Arg Cys Asp
        35                  40                  45              
Lys Tyr Asp Ile Met His Leu Arg Pro Met Gly Asp Leu Gly Gln Leu
    50                  55                  60                  
Leu Phe Leu Glu Trp Asp Ala Arg Asp Lys Asp Ser Ile Arg Arg Val
65                  70                  75                  80  
Val Gln His Ser Asn Val Val Ile Asn Leu Ile Gly Arg Asp Trp Glu
                85                  90                  95      
Thr Lys Asn Phe Asp Phe Glu Asp Val Phe Val Lys Ile Pro Gln Ala
            100                 105                 110         
Ile Ala Gln Leu Ser Lys Glu Ala Gly Val Glu Lys Phe Ile His Val
        115                 120                 125             
Ser His Leu Asn Ala Asn Ile Lys Ser Ser Ser Arg Tyr Leu Arg Asn
    130                 135                 140                 
Lys Ala Val Gly Glu Lys Val Val Arg Asp Ala Phe Pro Glu Ala Ile
145                 150                 155                 160 
Ile Val Lys Pro Ser Asp Ile Phe Gly Arg Glu Asp Arg Phe Leu Asn
                165                 170                 175     
Ser Phe Ala Ser Met His Arg Phe Gly Pro Ile Pro Leu Gly Ser Leu
            180                 185                 190         
Gly Trp Lys Thr Val Lys Gln Pro Val Tyr Val Val Asp Val Ser Lys
        195                 200                 205             
Gly Ile Val Asn Ala Val Lys Asp Pro Asp Ala Asn Gly Lys Ser Phe
    210                 215                 220                 
Ala Phe Val Gly Pro Ser Arg Tyr Leu Leu Phe His Leu Val Lys Tyr
225                 230                 235                 240 
Ile Phe Ala Val Ala His Arg Leu Phe Leu Pro Phe Pro Leu Pro Leu
                245                 250                 255     
Phe Ala Tyr Arg Trp Val Ala Arg Val Phe Glu Ile Ser Pro Phe Glu
            260                 265                 270         
Pro Trp Ile Thr Arg Asp Lys Val Glu Arg Met His Ile Thr Asp Met
        275                 280                 285             
Lys Leu Pro His Leu Pro Gly Leu Glu Asp Leu Gly Ile Gln Ala Thr
    290                 295                 300                 
Pro Leu Glu Leu Lys Ala Ile Glu Val Leu Arg Arg His Arg Thr Tyr
305                 310                 315                 320 
Arg Trp Leu Ser Ala Glu Ile Glu Asp Val Lys Pro Ala Lys Thr Val
                325                 330                 335     
Asn Ile
        


<210> 1458
<211> 74
<212> PRT
<213> Homo sapiens

<400> 1458
Met Asn Phe Lys Trp Ser Arg Arg Ser Leu Arg Val Ser Val Leu Thr
 1               5                  10                  15      
Phe Ser Pro Arg Pro Ser Cys His His Ile Thr Gly Cys His Trp Arg
            20                  25                  30          
Val Ala Val Asn Val Leu Arg Cys Tyr Ile Arg Ile Ser Ala Val Gln
        35                  40                  45              
Ala Ser Lys Pro Val Gln Cys Ile Arg Ala Thr Gly Ser Gly Gly Ala
    50                  55                  60                  
Cys Leu Ser Val Cys Pro Ala Gly Glu Leu
65                  70                  


<210> 1459
<211> 749
<212> PRT
<213> Homo sapiens

<400> 1459
Met Ala Ala Ala Gly Ser Arg Lys Arg Arg Leu Ala Glu Leu Thr Val
 1               5                  10                  15      
Asp Glu Phe Leu Ala Ser Gly Phe Asp Ser Glu Ser Glu Ser Glu Ser
            20                  25                  30          
Glu Asn Ser Pro Gln Ala Glu Thr Arg Glu Ala Arg Glu Ala Ala Arg
        35                  40                  45              
Ser Pro Asp Lys Pro Gly Gly Ser Pro Ser Ala Ser Arg Arg Lys Gly
    50                  55                  60                  
Arg Ala Ser Glu His Lys Asp Gln Leu Ser Arg Leu Lys Asp Arg Asp
65                  70                  75                  80  
Pro Glu Phe Tyr Lys Phe Leu Gln Glu Asn Asp Gln Ser Leu Leu Asn
                85                  90                  95      
Phe Ser Asp Ser Asp Ser Ser Glu Glu Glu Glu Gly Pro Phe His Ser
            100                 105                 110         
Leu Pro Asp Val Leu Glu Glu Ala Ser Glu Glu Glu Asp Gly Ala Glu
        115                 120                 125             
Glu Gly Glu Asp Gly Asp Arg Val Pro Arg Gly Leu Lys Gly Lys Lys
    130                 135                 140                 
Asn Ser Val Pro Val Thr Val Ala Met Val Glu Arg Trp Lys Gln Ala
145                 150                 155                 160 
Ala Lys Gln Arg Leu Thr Pro Lys Leu Phe His Glu Val Val Gln Ala
                165                 170                 175     
Phe Arg Ala Ala Val Ala Thr Thr Arg Gly Asp Gln Glu Ser Ala Glu
            180                 185                 190         
Ala Asn Lys Phe Gln Val Thr Asp Ser Ala Ala Phe Asn Ala Leu Val
        195                 200                 205             
Thr Phe Cys Ile Arg Asp Leu Ile Gly Cys Leu Gln Lys Leu Leu Phe
    210                 215                 220                 
Gly Lys Val Ala Lys Asp Ser Ser Arg Met Leu Gln Pro Ser Ser Ser
225                 230                 235                 240 
Pro Leu Trp Gly Lys Leu Arg Val Asp Ile Lys Ala Tyr Leu Gly Ser
                245                 250                 255     
Ala Ile Gln Leu Val Ser Cys Leu Ser Glu Thr Thr Val Leu Ala Ala
            260                 265                 270         
Val Leu Arg His Ile Ser Val Leu Val Pro Cys Phe Leu Thr Phe Pro
        275                 280                 285             
Lys Gln Cys Arg Met Leu Leu Lys Arg Met Val Val Val Trp Ser Thr
    290                 295                 300                 
Gly Glu Glu Ser Leu Arg Val Leu Ala Phe Leu Val Leu Ser Arg Val
305                 310                 315                 320 
Cys Arg His Lys Lys Asp Thr Phe Leu Gly Pro Val Leu Lys Gln Met
                325                 330                 335     
Tyr Ile Thr Tyr Val Arg Asn Cys Lys Phe Thr Ser Pro Gly Ala Leu
            340                 345                 350         
Pro Phe Ile Ser Phe Met Gln Trp Thr Leu Thr Glu Leu Leu Ala Leu
        355                 360                 365             
Glu Pro Gly Val Ala Tyr Gln His Ala Phe Leu Tyr Ile Arg Gln Leu
    370                 375                 380                 
Ala Ile His Leu Arg Asn Ala Met Thr Thr Arg Lys Lys Glu Thr Tyr
385                 390                 395                 400 
Gln Ser Val Tyr Asn Trp Gln Tyr Val His Cys Leu Phe Leu Trp Cys
                405                 410                 415     
Arg Val Leu Ser Thr Ala Gly Pro Ser Glu Ala Leu Gln Pro Leu Val
            420                 425                 430         
Tyr Pro Leu Ala Gln Val Ile Ile Gly Cys Ile Lys Leu Ile Pro Thr
        435                 440                 445             
Ala Arg Phe Tyr Pro Leu Arg Met His Cys Ile Arg Ala Leu Thr Leu
    450                 455                 460                 
Leu Ser Gly Ser Ser Gly Ala Phe Ile Pro Val Leu Pro Phe Ile Leu
465                 470                 475                 480 
Glu Met Phe Gln Gln Val Asp Phe Asn Arg Lys Pro Gly Arg Met Ser
                485                 490                 495     
Ser Lys Pro Ile Asn Phe Ser Val Ile Leu Lys Leu Ser Asn Val Asn
            500                 505                 510         
Leu Gln Glu Lys Ala Tyr Arg Asp Gly Leu Val Glu Gln Leu Tyr Asp
        515                 520                 525             
Leu Thr Leu Glu Tyr Leu His Ser Gln Ala His Cys Ile Gly Phe Pro
    530                 535                 540                 
Glu Leu Val Leu Pro Val Val Leu Gln Leu Lys Ser Phe Leu Arg Glu
545                 550                 555                 560 
Cys Lys Val Ala Asn Tyr Cys Arg Gln Val Gln Gln Leu Leu Gly Lys
                565                 570                 575     
Val Gln Glu Asn Ser Ala Tyr Ile Cys Ser Arg Arg Gln Arg Val Ser
            580                 585                 590         
Phe Gly Val Ser Glu Gln Gln Ala Val Glu Ala Trp Glu Lys Leu Thr
        595                 600                 605             
Arg Glu Glu Gly Thr Pro Leu Thr Leu Tyr Tyr Ser His Trp Arg Lys
    610                 615                 620                 
Leu Arg Asp Arg Glu Ile Gln Leu Glu Ile Ser Gly Lys Glu Arg Leu
625                 630                 635                 640 
Glu Asp Leu Asn Phe Pro Glu Ile Lys Arg Arg Lys Met Ala Asp Arg
                645                 650                 655     
Lys Asp Glu Asp Arg Lys Gln Phe Lys Asp Leu Phe Asp Leu Asn Ser
            660                 665                 670         
Ser Glu Glu Asp Asp Thr Glu Gly Phe Ser Glu Arg Gly Ile Leu Arg
        675                 680                 685             
Pro Leu Ser Thr Arg His Gly Val Glu Asp Asp Glu Glu Asp Glu Glu
    690                 695                 700                 
Glu Gly Glu Glu Asp Ser Ser Asn Ser Glu Asp Gly Asp Pro Asp Ala
705                 710                 715                 720 
Glu Ala Gly Leu Ala Pro Gly Glu Leu Gln Gln Leu Ala Gln Gly Pro
                725                 730                 735     
Glu Asp Glu Leu Glu Asp Leu Gln Leu Ser Glu Asp Asp
            740                 745                 


<210> 1460
<211> 544
<212> PRT
<213> Homo sapiens

<400> 1460
Met Leu Ala Phe Ala Ala Arg Thr Val Val Lys Pro Leu Gly Phe Leu
 1               5                  10                  15      
Lys Pro Phe Ser Leu Met Lys Ala Ser Ser Arg Phe Lys Ala His Gln
            20                  25                  30          
Asp Ala Leu Pro Arg Leu Pro Val Pro Pro Leu Gln Gln Ser Leu Asp
        35                  40                  45              
His Tyr Leu Lys Ala Leu Gln Pro Ile Val Ser Glu Glu Glu Trp Ala
    50                  55                  60                  
His Thr Lys Gln Leu Val Asp Glu Phe Gln Ala Ser Gly Gly Val Gly
65                  70                  75                  80  
Glu Arg Leu Gln Lys Gly Leu Glu Arg Arg Ala Arg Lys Thr Glu Asn
                85                  90                  95      
Trp Leu Ser Glu Trp Trp Leu Lys Thr Ala Tyr Leu Gln Tyr Arg Gln
            100                 105                 110         
Pro Val Val Ile Tyr Ser Ser Pro Gly Val Met Leu Pro Lys Gln Asp
        115                 120                 125             
Phe Val Asp Leu Gln Gly Gln Leu Arg Phe Ala Ala Lys Leu Ile Glu
    130                 135                 140                 
Gly Val Leu Asp Phe Lys Val Met Ile Asp Asn Glu Thr Leu Pro Val
145                 150                 155                 160 
Glu Tyr Leu Gly Gly Lys Pro Leu Cys Met Asn Gln Tyr Tyr Gln Ile
                165                 170                 175     
Leu Ser Ser Cys Arg Val Pro Gly Pro Lys Gln Asp Thr Val Ser Asn
            180                 185                 190         
Phe Ser Lys Thr Lys Lys Pro Pro Thr His Ile Thr Val Val His Asn
        195                 200                 205             
Tyr Gln Phe Phe Glu Leu Asp Val Tyr His Ser Asp Gly Thr Pro Leu
    210                 215                 220                 
Thr Ala Asp Gln Ile Phe Val Gln Leu Glu Lys Ile Trp Asn Ser Ser
225                 230                 235                 240 
Leu Gln Thr Asn Lys Glu Pro Val Gly Ile Leu Thr Ser Asn His Arg
                245                 250                 255     
Asn Ser Trp Ala Lys Ala Tyr Asn Thr Leu Ile Lys Asp Lys Val Asn
            260                 265                 270         
Arg Asp Ser Val Arg Ser Ile Gln Lys Lys Pro Glu Leu Val Arg Ser
        275                 280                 285             
Pro Met Val Pro Leu Pro Met Pro Lys Lys Leu Arg Phe Asn Ile Thr
    290                 295                 300                 
Pro Glu Ile Lys Ser Asp Ile Glu Lys Ala Lys Gln Asn Leu Ser Ile
305                 310                 315                 320 
Met Ile Gln Asp Leu Asp Ile Thr Val Met Val Phe His His Phe Gly
                325                 330                 335     
Lys Asp Phe Pro Lys Ser Glu Lys Leu Ser Pro Asp Ala Phe Ile Gln
            340                 345                 350         
Met Ala Leu Gln Leu Ala Tyr Tyr Arg Ile Tyr Gly Gln Ala Cys Ala
        355                 360                 365             
Thr Tyr Glu Ser Ala Ser Leu Arg Met Phe His Leu Gly Arg Thr Asp
    370                 375                 380                 
Thr Ile Arg Ser Ala Ser Met Asp Ser Leu Thr Phe Val Lys Ala Met
385                 390                 395                 400 
Asp Asp Ser Ser Val Thr Glu His Gln Lys Val Glu Leu Leu Arg Lys
                405                 410                 415     
Ala Val Gln Ala His Arg Gly Tyr Thr Asp Arg Ala Ile Arg Gly Glu
            420                 425                 430         
Ala Phe Asp Arg His Leu Leu Gly Leu Lys Leu Gln Ala Ile Glu Asp
        435                 440                 445             
Leu Val Ser Met Pro Asp Ile Phe Met Asp Thr Ser Tyr Ala Ile Ala
    450                 455                 460                 
Met His Phe His Leu Ser Thr Ser Gln Val Pro Ala Lys Thr Asp Cys
465                 470                 475                 480 
Val Met Phe Phe Gly Pro Val Val Pro Asp Gly Tyr Gly Val Cys Tyr
                485                 490                 495     
Asn Pro Met Glu Ala His Ile Asn Phe Ser Leu Ser Ala Tyr Asn Ser
            500                 505                 510         
Cys Ala Glu Thr Asn Ala Ala Arg Leu Ala His Tyr Leu Glu Lys Ala
        515                 520                 525             
Leu Leu Asp Met Arg Ala Leu Leu Gln Ser His Pro Arg Ala Lys Leu
    530                 535                 540                 


<210> 1461
<211> 489
<212> PRT
<213> Homo sapiens

<400> 1461
Met Val Pro Ser Ser Pro Ala Val Glu Lys Gln Val Pro Val Glu Pro
 1               5                  10                  15      
Gly Pro Asp Pro Glu Leu Arg Ser Trp Arg Arg Leu Val Cys Tyr Leu
            20                  25                  30          
Cys Phe Tyr Gly Phe Met Ala Gln Ile Arg Pro Gly Glu Ser Phe Ile
        35                  40                  45              
Thr Pro Tyr Leu Leu Gly Pro Asp Lys Asn Phe Thr Arg Glu Gln Val
    50                  55                  60                  
Thr Asn Glu Ile Thr Pro Val Leu Ser Tyr Ser Tyr Leu Ala Val Leu
65                  70                  75                  80  
Val Pro Val Phe Leu Leu Thr Asp Tyr Leu Arg Tyr Thr Pro Val Leu
                85                  90                  95      
Leu Leu Gln Gly Leu Ser Phe Val Ser Val Trp Leu Leu Leu Leu Leu
            100                 105                 110         
Gly His Ser Val Ala His Met Gln Leu Met Glu Leu Phe Tyr Ser Val
        115                 120                 125             
Thr Met Ala Ala Arg Ile Ala Tyr Ser Ser Tyr Ile Phe Ser Leu Val
    130                 135                 140                 
Arg Pro Ala Arg Tyr Gln Arg Val Ala Gly Tyr Ser Arg Ala Ala Val
145                 150                 155                 160 
Leu Leu Gly Val Phe Thr Ser Ser Val Leu Gly Gln Leu Leu Val Thr
                165                 170                 175     
Val Gly Arg Val Ser Phe Ser Thr Leu Asn Tyr Ile Ser Leu Ala Phe
            180                 185                 190         
Leu Thr Phe Ser Val Val Leu Ala Leu Phe Leu Lys Arg Pro Lys Arg
        195                 200                 205             
Ser Leu Phe Phe Asn Arg Asp Asp Arg Gly Arg Cys Glu Thr Ser Ala
    210                 215                 220                 
Ser Glu Leu Glu Arg Met Asn Pro Gly Pro Gly Gly Lys Leu Gly His
225                 230                 235                 240 
Ala Leu Arg Val Ala Cys Gly Asp Ser Val Leu Ala Arg Met Leu Arg
                245                 250                 255     
Glu Leu Gly Asp Ser Leu Arg Arg Pro Gln Leu Arg Leu Trp Ser Leu
            260                 265                 270         
Trp Trp Val Phe Asn Ser Ala Gly Tyr Tyr Leu Val Val Tyr Tyr Val
        275                 280                 285             
His Ile Leu Trp Asn Glu Val Asp Pro Thr Thr Asn Ser Ala Arg Val
    290                 295                 300                 
Tyr Asn Gly Ala Ala Asp Ala Ala Ser Thr Leu Leu Gly Ala Ile Thr
305                 310                 315                 320 
Ser Phe Ala Ala Gly Phe Val Lys Ile Arg Trp Ala Arg Trp Ser Lys
                325                 330                 335     
Leu Leu Ile Ala Gly Val Thr Ala Thr Gln Ala Gly Leu Val Phe Leu
            340                 345                 350         
Leu Ala His Thr Arg His Pro Ser Ser Ile Trp Leu Cys Tyr Ala Ala
        355                 360                 365             
Phe Val Leu Phe Arg Gly Ser Tyr Gln Phe Leu Val Pro Ile Ala Thr
    370                 375                 380                 
Phe Gln Ile Ala Ser Ser Leu Ser Lys Glu Leu Cys Ala Leu Val Phe
385                 390                 395                 400 
Gly Val Asn Thr Phe Phe Ala Thr Ile Val Lys Thr Ile Ile Thr Phe
                405                 410                 415     
Ile Val Ser Asp Val Arg Gly Leu Gly Leu Pro Val Arg Lys Gln Asn
            420                 425                 430         
Glu Glu Leu His Val Ala Ser Leu Ser Leu Trp Lys Ser His Leu Arg
        435                 440                 445             
Leu Ala Ala Asp Thr Leu Ser Ser Glu Gly Ser Ser Gly Ser Gly Pro
    450                 455                 460                 
Arg Ser Trp Phe Leu Ser Pro Thr Leu Arg Ala Ala Leu His Gly Pro
465                 470                 475                 480 
Val Cys Pro Ser Glu Val Cys Pro Ser
                485                 


<210> 1462
<211> 217
<212> PRT
<213> Homo sapiens

<400> 1462
Met Ser Cys Ala Gly Ala Ala Ala Ala Pro Arg Leu Trp Arg Leu Arg
 1               5                  10                  15      
Pro Gly Ala Arg Arg Ser Leu Ser Ala Tyr Gly Arg Arg Thr Ser Val
            20                  25                  30          
Arg Phe Arg Ser Ser Gly Met Thr Leu Asp Asn Ile Ser Arg Ala Ala
        35                  40                  45              
Val Asp Arg Ile Ile Arg Val Asp His Ala Gly Glu Tyr Gly Ala Asn
    50                  55                  60                  
Arg Ile Tyr Ala Gly Gln Met Ala Val Leu Gly Arg Thr Ser Val Gly
65                  70                  75                  80  
Pro Val Ile Gln Lys Met Trp Asp Gln Glu Lys Asp His Leu Lys Lys
                85                  90                  95      
Phe Asn Glu Leu Met Val Thr Phe Arg Val Arg Pro Thr Val Leu Met
            100                 105                 110         
Pro Leu Trp Asn Val Leu Gly Phe Ala Leu Gly Ala Gly Thr Ala Leu
        115                 120                 125             
Leu Gly Lys Glu Gly Ala Met Ala Cys Thr Val Ala Val Glu Glu Ser
    130                 135                 140                 
Ile Ala His His Tyr Asn Asn Gln Ile Arg Thr Leu Met Glu Glu Asp
145                 150                 155                 160 
Pro Glu Lys Tyr Glu Glu Leu Leu Gln Leu Ile Lys Lys Phe Arg Asp
                165                 170                 175     
Glu Glu Leu Glu His His Asp Ile Gly Leu Asp His Asp Ala Glu Leu
            180                 185                 190         
Ala Pro Ala Tyr Ala Val Leu Lys Ser Ile Ile Gln Ala Gly Cys Arg
        195                 200                 205             
Val Ala Ile Tyr Leu Ser Glu Arg Leu
    210                 215         


<210> 1463
<211> 514
<212> PRT
<213> Homo sapiens

<400> 1463
Gly Gly Gly Phe Ala Ala Ser Val Asp Tyr Phe Pro Ser Glu Asp Phe
 1               5                  10                  15      
Tyr Arg Cys Gly Tyr Cys Lys Asn Glu Ser Gly Ser Arg Ser Asn Gly
            20                  25                  30          
Met Trp Ala His Ser Met Thr Val Gln Asp Tyr Gln Asp Leu Ile Asp
        35                  40                  45              
Arg Gly Trp Arg Arg Ser Gly Lys Tyr Val Tyr Lys Pro Val Met Asn
    50                  55                  60                  
Gln Thr Cys Cys Pro Gln Tyr Thr Ile Arg Cys Arg Pro Leu Gln Phe
65                  70                  75                  80  
Gln Pro Ser Lys Ser His Lys Lys Val Leu Lys Lys Met Leu Lys Phe
                85                  90                  95      
Leu Ala Lys Gly Glu Val Pro Lys Gly Ser Cys Glu Asp Glu Pro Met
            100                 105                 110         
Asp Ser Thr Met Asp Asp Ala Val Ala Gly Asp Phe Ala Leu Ile Asn
        115                 120                 125             
Lys Leu Asp Ile Gln Cys Asp Leu Lys Thr Leu Ser Asp Asp Ile Lys
    130                 135                 140                 
Glu Ser Leu Glu Ser Glu Gly Lys Asn Ser Lys Lys Glu Glu Pro Gln
145                 150                 155                 160 
Glu Leu Leu Gln Ser Gln Asp Phe Val Gly Glu Lys Leu Gly Ser Gly
                165                 170                 175     
Glu Pro Ser His Ser Val Lys Val His Thr Val Pro Lys Pro Gly Lys
            180                 185                 190         
Gly Ala Asp Leu Ser Lys Pro Pro Cys Arg Lys Ala Lys Glu Ile Arg
        195                 200                 205             
Lys Glu Arg Lys Arg Leu Lys Leu Met Gln Gln Asn Pro Ala Gly Glu
    210                 215                 220                 
Leu Glu Gly Phe Gln Ala Gln Gly His Pro Pro Ser Leu Phe Pro Pro
225                 230                 235                 240 
Lys Ala Lys Ser Asn Gln Pro Lys Ser Leu Glu Asp Leu Ile Phe Glu
                245                 250                 255     
Ser Leu Pro Glu Asn Ala Ser His Lys Leu Glu Val Arg Val Val Arg
            260                 265                 270         
Ser Ser Pro Pro Ser Ser Gln Phe Lys Ala Thr Leu Leu Glu Ser Tyr
        275                 280                 285             
Gln Val Tyr Lys Arg Tyr Gln Met Val Ile His Lys Asn Pro Pro Asp
    290                 295                 300                 
Thr Pro Thr Glu Ser Gln Phe Thr Arg Phe Leu Cys Ser Ser Pro Leu
305                 310                 315                 320 
Glu Ala Glu Thr Pro Pro Asn Gly Pro Asp Cys Gly Tyr Gly Ser Phe
                325                 330                 335     
His Gln Gln Tyr Trp Leu Asp Gly Lys Ile Ile Ala Val Gly Val Ile
            340                 345                 350         
Asp Ile Leu Pro Asn Cys Val Ser Ser Val Tyr Leu Tyr Tyr Asp Pro
        355                 360                 365             
Asp Tyr Ser Phe Leu Ser Leu Gly Val Tyr Ser Ala Leu Arg Glu Ile
    370                 375                 380                 
Ala Phe Thr Arg Gln Leu His Glu Lys Thr Ser Gln Leu Ser Tyr Tyr
385                 390                 395                 400 
Tyr Met Gly Phe Tyr Ile His Ser Cys Pro Lys Met Lys Tyr Lys Gly
                405                 410                 415     
Gln Tyr Arg Pro Ser Asp Leu Leu Cys Pro Glu Thr Tyr Val Trp Val
            420                 425                 430         
Pro Ile Glu Gln Cys Leu Pro Ser Leu Glu Asn Ser Lys Tyr Cys Arg
        435                 440                 445             
Phe Asn Gln Asp Pro Glu Ala Val Asp Glu Asp Arg Ser Thr Glu Pro
    450                 455                 460                 
Asp Arg Leu Gln Val Phe His Lys Arg Ala Ile Met Pro Tyr Gly Val
465                 470                 475                 480 
Tyr Lys Lys Gln Gln Lys Asp Pro Ser Glu Glu Ala Ala Val Leu Gln
                485                 490                 495     
Tyr Ala Ser Leu Val Gly Gln Lys Cys Ser Glu Arg Met Leu Leu Phe
            500                 505                 510         
Arg Asn
        


<210> 1464
<211> 551
<212> PRT
<213> Homo sapiens

<400> 1464
Arg Pro Arg Pro Gly Leu Arg Gly Gly Arg Ala Pro Cys Glu Val Thr
 1               5                  10                  15      
Met Glu Ala Gly Gly Leu Pro Leu Glu Leu Trp Arg Met Ile Leu Ala
            20                  25                  30          
Tyr Leu His Leu Pro Asp Leu Gly Arg Cys Ser Leu Val Cys Arg Ala
        35                  40                  45              
Trp Tyr Glu Leu Ile Leu Ser Leu Asp Ser Thr Arg Trp Arg Gln Leu
    50                  55                  60                  
Cys Leu Gly Cys Thr Glu Cys Arg His Pro Asn Trp Pro Asn Gln Pro
65                  70                  75                  80  
Asp Val Glu Pro Glu Ser Trp Arg Glu Ala Phe Lys Gln His Tyr Leu
                85                  90                  95      
Ala Ser Lys Thr Trp Thr Lys Asn Ala Leu Asp Leu Glu Ser Ser Ile
            100                 105                 110         
Cys Phe Ser Leu Phe Arg Arg Arg Arg Glu Arg Arg Thr Leu Ser Val
        115                 120                 125             
Gly Pro Gly Arg Glu Phe Asp Ser Leu Gly Ser Ala Leu Ala Met Ala
    130                 135                 140                 
Ser Leu Tyr Asp Arg Ile Val Leu Phe Pro Gly Val Tyr Glu Glu Gln
145                 150                 155                 160 
Gly Glu Ile Ile Leu Lys Val Pro Val Glu Ile Val Gly Gln Gly Lys
                165                 170                 175     
Leu Gly Glu Val Ala Leu Leu Ala Ser Ile Asp Gln His Cys Ser Thr
            180                 185                 190         
Thr Arg Leu Cys Asn Leu Val Phe Thr Pro Ala Trp Phe Ser Pro Ile
        195                 200                 205             
Met Tyr Lys Thr Thr Ser Gly His Val Gln Phe Asp Asn Cys Asn Phe
    210                 215                 220                 
Glu Asn Gly His Ile Gln Val His Gly Pro Gly Thr Cys Gln Val Lys
225                 230                 235                 240 
Phe Cys Thr Phe Lys Asn Thr His Ile Phe Leu His Asn Val Pro Leu
                245                 250                 255     
Cys Val Leu Glu Asn Cys Glu Phe Val Gly Ser Glu Asn Asn Ser Val
            260                 265                 270         
Thr Val Glu Gly His Pro Ser Ala Asp Lys Asn Trp Ala Tyr Lys Tyr
        275                 280                 285             
Leu Leu Gly Leu Ile Lys Ser Ser Pro Thr Phe Leu Pro Thr Glu Asp
    290                 295                 300                 
Ser Asp Phe Leu Met Ser Leu Asp Leu Glu Ser Arg Asp Gln Ala Trp
305                 310                 315                 320 
Ser Pro Lys Thr Cys Asp Ile Val Ile Glu Gly Ser Gln Ser Pro Thr
                325                 330                 335     
Ser Pro Ala Ser Ser Ser Pro Lys Pro Gly Ser Lys Ala Gly Ser Gln
            340                 345                 350         
Glu Ala Glu Val Gly Ser Asp Gly Glu Arg Val Ala Gln Thr Pro Asp
        355                 360                 365             
Ser Ser Asp Gly Gly Leu Ser Pro Ser Gly Glu Asp Glu Asp Glu Asp
    370                 375                 380                 
Gln Leu Met Tyr Arg Leu Ser Tyr Gln Val Gln Gly Pro Arg Pro Val
385                 390                 395                 400 
Leu Gly Gly Ser Phe Leu Gly Pro Pro Leu Pro Gly Ala Ser Ile Gln
                405                 410                 415     
Leu Pro Ser Cys Leu Val Leu Asn Ser Leu Gln Gln Glu Leu Gln Lys
            420                 425                 430         
Asp Lys Glu Ala Met Ala Leu Ala Asn Ser Val Gln Gly Cys Leu Ile
        435                 440                 445             
Arg Lys Cys Leu Phe Arg Asp Gly Lys Gly Gly Val Phe Val Cys Ser
    450                 455                 460                 
His Gly Arg Ala Lys Met Glu Gly Asn Ile Phe Arg Asn Leu Thr Tyr
465                 470                 475                 480 
Ala Val Arg Cys Ile His Asn Ser Lys Ile Ile Met Leu Arg Asn Asp
                485                 490                 495     
Ile Tyr Arg Cys Arg Ala Ser Gly Ile Phe Leu Arg Leu Glu Gly Gly
            500                 505                 510         
Gly Leu Ile Ala Gly Asn Asn Ile Tyr His Asn Ala Glu Ala Gly Val
        515                 520                 525             
Asp Ile Arg Lys Lys Ser Asn Pro Leu Gln Ile Gly Asn Pro Arg Ala
    530                 535                 540                 
Glu Phe Leu Ala Ser Arg Ala
545                 550     


<210> 1465
<211> 393
<212> PRT
<213> Homo sapiens

<400> 1465
Met Gly Lys Ser Asp Phe Leu Thr Pro Lys Ala Ile Ala Asn Arg Ile
 1               5                  10                  15      
Lys Ser Lys Gly Leu Gln Lys Leu Arg Trp Tyr Cys Gln Met Cys Gln
            20                  25                  30          
Lys Gln Cys Arg Asp Glu Asn Gly Phe Lys Cys His Cys Met Ser Glu
        35                  40                  45              
Ser His Gln Arg Gln Leu Leu Leu Ala Ser Glu Asn Pro Gln Gln Phe
    50                  55                  60                  
Met Asp Tyr Phe Ser Glu Glu Phe Arg Asn Asp Phe Leu Glu Leu Leu
65                  70                  75                  80  
Arg Arg Arg Phe Gly Thr Lys Arg Val His Asn Asn Ile Val Tyr Asn
                85                  90                  95      
Glu Tyr Ile Ser His Arg Glu His Ile His Met Asn Ala Thr Gln Trp
            100                 105                 110         
Glu Thr Leu Thr Asp Phe Thr Lys Trp Leu Gly Arg Glu Gly Leu Cys
        115                 120                 125             
Lys Val Asp Glu Thr Pro Lys Gly Trp Tyr Ile Gln Tyr Ile Asp Arg
    130                 135                 140                 
Asp Pro Glu Thr Ile Arg Arg Gln Leu Glu Leu Glu Lys Lys Lys Lys
145                 150                 155                 160 
Gln Asp Leu Asp Asp Glu Glu Lys Thr Ala Lys Phe Ile Glu Glu Gln
                165                 170                 175     
Val Arg Arg Gly Leu Glu Gly Lys Glu Gln Glu Val Pro Thr Phe Thr
            180                 185                 190         
Glu Leu Ser Arg Glu Asn Asp Glu Glu Lys Val Thr Phe Asn Leu Ser
        195                 200                 205             
Lys Gly Ala Cys Ser Ser Ser Gly Ala Thr Ser Ser Lys Ser Ser Thr
    210                 215                 220                 
Leu Gly Pro Ser Ala Leu Lys Thr Ile Gly Ser Ser Ala Ser Val Lys
225                 230                 235                 240 
Arg Lys Glu Ser Ser Gln Ser Ser Thr Gln Ser Lys Glu Lys Lys Lys
                245                 250                 255     
Lys Lys Ser Ala Leu Asp Glu Ile Met Glu Ile Glu Glu Glu Lys Lys
            260                 265                 270         
Arg Thr Ala Arg Thr Asp Tyr Trp Leu Gln Pro Glu Ile Ile Val Lys
        275                 280                 285             
Ile Ile Thr Lys Lys Leu Gly Glu Lys Tyr His Lys Lys Lys Ala Ile
    290                 295                 300                 
Val Lys Glu Val Ile Asp Lys Tyr Thr Ala Val Val Lys Met Ile Asp
305                 310                 315                 320 
Ser Gly Asp Lys Leu Lys Leu Asp Gln Thr His Leu Glu Thr Val Ile
                325                 330                 335     
Pro Ala Pro Gly Lys Arg Ile Leu Val Leu Asn Gly Gly Tyr Arg Gly
            340                 345                 350         
Asn Glu Gly Thr Leu Glu Ser Ile Asn Glu Lys Thr Phe Ser Ala Thr
        355                 360                 365             
Ile Val Ile Glu Thr Gly Pro Leu Lys Gly Arg Arg Val Glu Gly Ile
    370                 375                 380                 
Gln Tyr Glu Asp Ile Ser Lys Leu Ala
385                 390             


<210> 1466
<211> 176
<212> PRT
<213> Homo sapiens

<400> 1466
Met Ala Ala Arg Gly Arg Arg Ala Glu Pro Gln Gly Arg Glu Ala Pro
 1               5                  10                  15      
Gly Pro Ala Gly Gly Gly Gly Gly Gly Ser Arg Trp Ala Glu Ser Gly
            20                  25                  30          
Ser Gly Thr Ser Pro Glu Ser Gly Asp Glu Glu Val Ser Gly Ala Gly
        35                  40                  45              
Ser Ser Pro Val Ser Gly Gly Val Asn Leu Phe Ala Asn Asp Gly Ser
    50                  55                  60                  
Phe Leu Glu Leu Phe Lys Arg Lys Met Glu Glu Glu Gln Arg Gln Arg
65                  70                  75                  80  
Gln Glu Glu Pro Pro Pro Gly Pro Gln Arg Pro Asp Gln Ser Ala Ala
                85                  90                  95      
Ala Ala Gly Pro Gly Asp Pro Lys Arg Lys Gly Gly Pro Gly Ser Thr
            100                 105                 110         
Leu Ser Phe Val Gly Lys Arg Arg Gly Gly Asn Lys Leu Ala Leu Lys
        115                 120                 125             
Thr Gly Ile Val Ala Lys Lys Gln Lys Thr Glu Asp Glu Val Leu Thr
    130                 135                 140                 
Ser Lys Gly Asp Ala Trp Ala Lys Tyr Met Ala Glu Val Lys Lys Tyr
145                 150                 155                 160 
Lys Ala His Gln Cys Gly Asp Asp Asp Lys Thr Arg Pro Leu Val Lys
                165                 170                 175     


<210> 1467
<211> 230
<212> PRT
<213> Homo sapiens

<400> 1467
Met Ser Phe Lys Arg Glu Gly Asp Asp Trp Ser Gln Leu Asn Val Leu
 1               5                  10                  15      
Lys Lys Arg Arg Val Gly Asp Leu Leu Ala Ser Tyr Ile Pro Glu Asp
            20                  25                  30          
Glu Ala Leu Met Leu Arg Asp Gly Arg Phe Ala Cys Ala Ile Cys Pro
        35                  40                  45              
His Arg Pro Val Leu Asp Thr Leu Ala Met Leu Thr Ala His Arg Ala
    50                  55                  60                  
Gly Lys Lys His Leu Ser Ser Leu Gln Leu Phe Tyr Gly Lys Lys Gln
65                  70                  75                  80  
Pro Gly Lys Glu Arg Lys Gln Asn Pro Lys His Gln Asn Glu Leu Arg
                85                  90                  95      
Arg Glu Glu Thr Lys Ala Glu Ala Pro Leu Leu Thr Gln Thr Arg Leu
            100                 105                 110         
Ile Thr Gln Ser Ala Leu His Arg Ala Pro His Tyr Asn Ser Cys Cys
        115                 120                 125             
Arg Arg Lys Tyr Arg Pro Glu Ala Pro Gly Pro Ser Val Ser Leu Ser
    130                 135                 140                 
Pro Met Pro Pro Ser Glu Val Lys Leu Gln Ser Gly Lys Ile Ser Arg
145                 150                 155                 160 
Glu Pro Glu Pro Ala Ala Gly Pro Gln Ala Glu Glu Ser Ala Thr Val
                165                 170                 175     
Ser Ala Pro Ala Pro Met Ser Pro Thr Arg Arg Arg Ala Leu Asp His
            180                 185                 190         
Tyr Leu Thr Leu Arg Ser Ser Gly Trp Ile Pro Asp Gly Arg Gly Arg
        195                 200                 205             
Trp Val Lys Asp Glu Asn Val Glu Phe Asp Ser Asp Glu Glu Glu Pro
    210                 215                 220                 
Pro Asp Leu Pro Leu Asp
225                 230 


<210> 1468
<211> 83
<212> PRT
<213> Homo sapiens

<400> 1468
Met Gly Leu Met Thr Ala Pro His Thr His Gln Arg Gly Leu Gln Ile
 1               5                  10                  15      
Val Arg Asp Glu Arg Lys Ile Ser Gly Pro Gly Asp Ser Ile Ile Lys
            20                  25                  30          
Arg Lys Arg Met Arg Lys Lys Ile Ala Asp Glu Lys Asn Gln Pro Asn
        35                  40                  45              
Ser Gly Ser Trp Lys Ala Asp Ala Arg Arg Pro Leu Asn Asp Ala Ser
    50                  55                  60                  
Thr Leu Ile Leu Asp Phe Pro Ala Ser Arg Thr Met Ser Gln Tyr Ile
65                  70                  75                  80  
Ser Val Pro
            


<210> 1469
<211> 37
<212> PRT
<213> Homo sapiens

<400> 1469
Met Leu Pro Leu Lys Val Lys Gly Arg Arg Phe Tyr Phe Leu Leu Asp
 1               5                  10                  15      
Lys Thr Gly His Phe Pro Asn Thr Lys Leu Phe Asp Asn Thr Val Gly
            20                  25                  30          
Ala Tyr Arg Ser Leu
        35          


<210> 1470
<211> 243
<212> PRT
<213> Homo sapiens

<400> 1470
Met Ala Ala Ser Ser Ile Ser Ser Pro Trp Gly Lys His Val Phe Lys
 1               5                  10                  15      
Ala Ile Leu Met Val Leu Val Ala Leu Ile Leu Leu His Ser Ala Leu
            20                  25                  30          
Ala Gln Ser Arg Arg Asp Phe Ala Pro Pro Gly Gln Gln Lys Arg Glu
        35                  40                  45              
Ala Pro Val Asp Val Leu Thr Gln Ile Gly Arg Ser Val Arg Gly Thr
    50                  55                  60                  
Leu Asp Ala Trp Ile Gly Pro Glu Thr Met His Leu Val Ser Glu Ser
65                  70                  75                  80  
Ser Ser Gln Val Leu Trp Ala Ile Ser Ser Ala Ile Ser Val Ala Phe
                85                  90                  95      
Phe Ala Leu Ser Gly Ile Ala Ala Gln Leu Leu Asn Ala Leu Gly Leu
            100                 105                 110         
Ala Gly Asp Tyr Leu Ala Gln Gly Leu Lys Leu Ser Pro Gly Gln Val
        115                 120                 125             
Gln Thr Phe Leu Leu Trp Gly Ala Gly Ala Leu Val Val Tyr Trp Leu
    130                 135                 140                 
Leu Ser Leu Leu Leu Gly Leu Val Leu Ala Leu Leu Gly Arg Ile Leu
145                 150                 155                 160 
Trp Gly Leu Lys Leu Val Ile Phe Leu Ala Gly Phe Val Ala Leu Met
                165                 170                 175     
Arg Ser Val Pro Asp Pro Ser Thr Arg Ala Leu Leu Leu Leu Ala Leu
            180                 185                 190         
Leu Ile Leu Tyr Ala Leu Leu Ser Arg Leu Thr Gly Ser Arg Ala Ser
        195                 200                 205             
Gly Ala Gln Leu Glu Ala Lys Val Arg Gly Leu Glu Arg Gln Val Glu
    210                 215                 220                 
Glu Leu Arg Trp Arg Gln Arg Arg Ala Ala Lys Gly Ala Arg Ser Val
225                 230                 235                 240 
Glu Glu Glu
            


<210> 1471
<211> 158
<212> PRT
<213> Homo sapiens

<400> 1471
Met Phe Gly Gly Asp Thr Leu Tyr Glu Leu Arg Cys Ser Leu Gln Leu
 1               5                  10                  15      
Ala Glu Thr Glu Arg Glu Gly Gly Phe Ser Pro His Ile Ser Pro Phe
            20                  25                  30          
Thr Ala Val Asn Asp Leu Gly His Leu Leu Gly Arg Ala Gly Phe Asn
        35                  40                  45              
Thr Leu Thr Val Asp Thr Asp Glu Ile Gln Val Asn Tyr Pro Gly Met
    50                  55                  60                  
Phe Glu Leu Met Glu Asp Leu Gln Gly Met Gly Glu Ser Asn Cys Ala
65                  70                  75                  80  
Trp Asn Arg Lys Ala Leu Leu His Arg Asp Thr Met Leu Ala Ala Ala
                85                  90                  95      
Ala Val Tyr Arg Glu Met Tyr Arg Asn Glu Asp Gly Ser Val Pro Ala
            100                 105                 110         
Thr Tyr Gln Ile Tyr Tyr Met Ile Gly Trp Lys Tyr His Glu Ser Gln
        115                 120                 125             
Ala Arg Pro Ala Glu Arg Gly Ser Ala Thr Val Ser Phe Gly Glu Leu
    130                 135                 140                 
Gly Lys Ile Asn Asn Leu Met Pro Pro Gly Lys Lys Ser Gln
145                 150                 155             


<210> 1472
<211> 220
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 18
<223> Xaa = Any Amino Acid

<400> 1472
Thr Ser Trp Arg Arg Gly Glu Val Thr Pro Arg Arg Gly Ser Gly Gly
 1               5                  10                  15      
Gly Xaa Glu Thr Ile Gly Ala Lys Gln Gly Arg Thr Gln Leu Ser Ser
            20                  25                  30          
Gly Phe Val Asn Ser Thr Met Glu Glu Ala Gly Leu Cys Gly Leu Arg
        35                  40                  45              
Glu Lys Ala Asp Met Leu Cys Asn Ser Glu Ser His Asp Ile Leu Gln
    50                  55                  60                  
His Gln Asp Ser Asn Cys Ser Ala Thr Ser Asn Lys His Leu Leu Glu
65                  70                  75                  80  
Asp Glu Glu Gly Arg Asp Phe Ile Thr Lys Asn Arg Ser Trp Val Ser
                85                  90                  95      
Pro Val His Cys Thr Gln Glu Ser Arg Arg Glu Leu Pro Glu Gln Glu
            100                 105                 110         
Val Ala Pro Pro Ser Gly Gln Gln Ala Leu Gln Leu Gln Gln Glu Gln
        115                 120                 125             
Arg Lys Ser Leu Arg Lys Arg Ser Phe Ile Ile Asp Ala Ser Pro Lys
    130                 135                 140                 
His Ser Phe Arg Leu Gln Arg Arg Ser Trp Gln Leu Ser Val Arg Asn
145                 150                 155                 160 
Met Leu Ile Leu Glu Ile His Leu Phe Tyr Arg Arg Val Cys Phe Glu
                165                 170                 175     
Leu Tyr Asp Leu Lys Gln Asn Ser Phe Phe Gly Asp Tyr Gly Asn Ile
            180                 185                 190         
Leu Asn Arg Glu Thr Leu Leu Asp Phe Val Lys Gln Ile Met Glu Lys
        195                 200                 205             
Ile Gln Asn Phe Leu Lys Asn His Gly Lys Phe Leu
    210                 215                 220 


<210> 1473
<211> 83
<212> PRT
<213> Homo sapiens

<400> 1473
Met Ile Leu Lys His His Phe Asn Pro Val Phe Pro Leu Leu Thr Lys
 1               5                  10                  15      
Thr Asn Ser Gly Ile Lys Gly Thr Leu His Leu Gly Leu Lys Cys Leu
            20                  25                  30          
Ser Leu Leu Pro Val Leu Ser Pro Pro Phe Arg Ser Asp Arg Thr Thr
        35                  40                  45              
Gln Ser Pro Thr Leu Val Arg Leu Ile Leu Leu Leu Pro Phe Phe Ser
    50                  55                  60                  
Arg Asn Pro Ser Leu Asp Leu Arg Asn Ser Thr Ser His Leu Lys Val
65                  70                  75                  80  
Thr Val His
            


<210> 1474
<211> 335
<212> PRT
<213> Homo sapiens

<400> 1474
Met Pro Arg Pro Arg Leu Leu Ala Ala Leu Cys Gly Ala Leu Leu Cys
 1               5                  10                  15      
Ala Pro Ser Leu Leu Val Ala Leu Asp Ile Cys Ser Lys Asn Pro Cys
            20                  25                  30          
His Asn Gly Gly Leu Cys Glu Glu Ile Ser Gln Glu Val Arg Gly Asp
        35                  40                  45              
Val Phe Pro Ser Tyr Thr Cys Thr Cys Leu Lys Gly Tyr Ala Gly Asn
    50                  55                  60                  
His Cys Glu Thr Lys Cys Val Glu Pro Leu Gly Met Glu Asn Gly Asn
65                  70                  75                  80  
Ile Ala Asn Ser Gln Ile Ala Ala Ser Ser Val Arg Val Thr Phe Leu
                85                  90                  95      
Gly Leu Gln His Trp Val Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly
            100                 105                 110         
Met Val Asn Ala Trp Thr Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile
        115                 120                 125             
Gln Val Asn Leu Leu Arg Arg Met Trp Val Thr Gly Val Val Thr Gln
    130                 135                 140                 
Gly Ala Ser Arg Leu Ala Ser His Glu Tyr Leu Lys Ala Phe Lys Val
145                 150                 155                 160 
Ala Tyr Ser Leu Asn Gly His Glu Phe Asp Phe Ile His Asp Val Asn
                165                 170                 175     
Lys Lys His Lys Glu Phe Val Gly Asn Trp Asn Lys Asn Ala Val His
            180                 185                 190         
Val Asn Leu Phe Glu Thr Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr
        195                 200                 205             
Pro Thr Ser Cys His Thr Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly
    210                 215                 220                 
Cys Glu Leu Asn Gly Cys Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser
225                 230                 235                 240 
Ile Pro Asp Lys Gln Ile Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly
                245                 250                 255     
Leu His Leu Phe Ser Trp Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln
            260                 265                 270         
Gly Asn Phe Asn Ala Trp Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp
        275                 280                 285             
Leu Gln Ile Phe Pro Gly Asn Trp Asp Asn His Ser His Lys Lys Asn
    290                 295                 300                 
Leu Phe Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg Ile Leu Pro Val
305                 310                 315                 320 
Ala Trp His Asn Arg Ile Ala Leu Arg Leu Glu Leu Leu Gly Cys
                325                 330                 335 


<210> 1475
<211> 327
<212> PRT
<213> Homo sapiens

<400> 1475
His Glu Gly Lys Gln Leu Asp Thr Leu Gly Asn Asp Lys Gly Arg Leu
 1               5                  10                  15      
Gln Ser Glu Leu Lys Thr Met Gln Asp Ser Val Glu Tyr Phe Lys Thr
            20                  25                  30          
Lys Tyr Glu Glu Glu Ile Asn Lys Arg Thr Ala Ala Glu Asn Asp Phe
        35                  40                  45              
Val Val Leu Lys Lys Asp Val Asp Ala Ala Tyr Leu Asn Lys Val Glu
    50                  55                  60                  
Leu Glu Ala Lys Val Asp Ser Leu Asn Asp Glu Ile Asn Phe Leu Lys
65                  70                  75                  80  
Val Leu Tyr Asp Ala Glu Leu Ser Gln Met Gln Thr His Val Ser Asp
                85                  90                  95      
Thr Ser Val Val Leu Ser Met Asp Asn Asn Arg Asn Leu Asp Leu Asp
            100                 105                 110         
Ser Ile Ile Ala Glu Val Arg Ala Gln Tyr Glu Glu Ile Ala Gln Arg
        115                 120                 125             
Ser Lys Ala Glu Ala Glu Ala Leu Tyr Gln Thr Lys Val Gln Gln Leu
    130                 135                 140                 
Gln Ile Ser Val Asp Gln His Gly Asp Asn Leu Lys Asn Thr Lys Ser
145                 150                 155                 160 
Glu Ile Ala Glu Leu Asn Arg Met Ile Gln Arg Leu Arg Ala Glu Ile
                165                 170                 175     
Glu Asn Ile Lys Lys Gln Cys Gln Thr Leu Gln Val Ser Val Ala Asp
            180                 185                 190         
Ala Glu Gln Arg Gly Glu Asn Ala Leu Lys Asp Ala His Ser Lys Arg
        195                 200                 205             
Val Glu Leu Glu Ala Ala Leu Gln Gln Ala Lys Glu Glu Leu Ala Arg
    210                 215                 220                 
Met Leu Arg Glu Tyr Gln Glu Leu Met Ser Val Lys Leu Ala Leu Asp
225                 230                 235                 240 
Ile Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Tyr Arg
                245                 250                 255     
Met Ser Gly Glu Cys Gln Ser Ala Val Ser Ile Ser Val Val Ser Gly
            260                 265                 270         
Ser Thr Ser Thr Gly Gly Ile Ser Gly Gly Leu Gly Ser Gly Ser Gly
        275                 280                 285             
Phe Gly Leu Ser Ser Gly Phe Gly Ser Gly Ser Gly Ser Gly Phe Gly
    290                 295                 300                 
Phe Gly Gly Ser Val Ser Gly Ser Ser Ser Ser Lys Ile Ile Ser Thr
305                 310                 315                 320 
Thr Thr Leu Asn Lys Arg Arg
                325         


<210> 1476
<211> 586
<212> PRT
<213> Homo sapiens

<400> 1476
Met Glu Pro Ala Ala Ala Leu His Phe Ser Arg Pro Ala Ser Leu Leu
 1               5                  10                  15      
Leu Leu Leu Ser Leu Cys Ala Leu Val Ser Ala Gln Val Thr Val Val
            20                  25                  30          
Gly Pro Thr Asp Pro Ile Leu Ala Met Val Gly Glu Asn Thr Thr Leu
        35                  40                  45              
Arg Cys Cys Leu Ser Pro Glu Glu Asn Ala Glu Asp Met Glu Val Arg
    50                  55                  60                  
Trp Phe Gln Ser Gln Phe Ser Pro Ala Val Phe Val Tyr Lys Gly Gly
65                  70                  75                  80  
Arg Glu Arg Thr Glu Glu Gln Lys Glu Glu Tyr Arg Gly Arg Thr Thr
                85                  90                  95      
Phe Val Ser Lys Asp Ser Arg Gly Ser Val Ala Leu Ile Ile His Asn
            100                 105                 110         
Val Thr Ala Glu Asp Asn Gly Ile Tyr Gln Cys Tyr Phe Gln Glu Gly
        115                 120                 125             
Arg Ser Cys Asn Glu Ala Ile Leu His Leu Val Val Ala Gly Leu Asp
    130                 135                 140                 
Ser Glu Pro Val Ile Glu Met Arg Asp His Glu Asp Gly Gly Ile Gln
145                 150                 155                 160 
Leu Glu Cys Ile Ser Gly Gly Trp Tyr Pro Lys Pro Leu Thr Val Trp
                165                 170                 175     
Arg Asp Pro Tyr Gly Glu Val Val Pro Ala Leu Lys Glu Val Ser Thr
            180                 185                 190         
Pro Asp Ala Asp Ser Leu Phe Met Val Thr Thr Ala Val Ile Ile Arg
        195                 200                 205             
Asp Lys Ser Val Arg Asn Val Ser Cys Ser Ile Asn Asp Thr Leu Leu
    210                 215                 220                 
Gly Gln Lys Lys Glu Ser Val Ile Phe Ile Pro Glu Ser Phe Met Pro
225                 230                 235                 240 
Ser Arg Ser Pro Cys Val Val Ile Leu Pro Val Ile Met Ile Ile Leu
                245                 250                 255     
Met Ile Pro Ile Ala Ile Cys Ile Tyr Trp Ile Asn Asn Leu Gln Lys
            260                 265                 270         
Glu Lys Lys Asp Ser His Leu Met Thr Phe Asn Leu Cys Leu Ser Leu
        275                 280                 285             
Ala Gly Trp Arg Arg Thr Phe Leu His Ala Ala Asn Val Val Leu Asp
    290                 295                 300                 
Gln Asp Thr Gly His Pro Tyr Leu Phe Val Ser Glu Asp Lys Arg Ser
305                 310                 315                 320 
Val Thr Leu Asp Pro Ser Arg Glu Ser Ile Pro Gly Asn Pro Glu Arg
                325                 330                 335     
Phe Asp Ser Gln Leu Cys Val Leu Gly Gln Glu Ser Phe Ala Ser Gly
            340                 345                 350         
Lys His Tyr Leu Glu Val Asp Val Glu Asn Val Ile Glu Trp Thr Val
        355                 360                 365             
Gly Ile Cys Arg Asp Asn Val Glu Arg Lys Trp Glu Val Pro Leu Leu
    370                 375                 380                 
Pro Gln Asn Gly Phe Trp Thr Leu Glu Met His Lys Arg Lys Tyr Trp
385                 390                 395                 400 
Ala Leu Thr Ser Leu Lys Trp Ile Leu Ser Leu Glu Glu Pro Leu Cys
                405                 410                 415     
Gln Val Gly Ile Phe Leu Asp Tyr Glu Ala Gly Asp Val Ser Phe Tyr
            420                 425                 430         
Asn Met Arg Asp Arg Ser His Ile Tyr Thr Phe Pro His Ser Ala Phe
        435                 440                 445             
Ser Val Pro Val Arg Pro Phe Phe Ser Leu Gly Ser Tyr Asp Ser Gln
    450                 455                 460                 
Ile Leu Ile Cys Ser Ala Phe Thr Gly Ala Ser Gly Val Thr Val Pro
465                 470                 475                 480 
Glu Glu Gly Trp Thr Leu His Arg Ala Gly Thr His His Ser Pro Gln
                485                 490                 495     
Asn Gln Phe Pro Ser Leu Thr Ala Met Glu Thr Ser Pro Gly His Leu
            500                 505                 510         
Ser Ser His Cys Thr Met Pro Leu Val Glu Asp Thr Pro Ser Ser Pro
        515                 520                 525             
Leu Val Thr Gln Glu Asn Ile Phe Gln Leu Pro Leu Ser His Pro Leu
    530                 535                 540                 
Gln Thr Ser Ala Pro Val His Leu Leu Ile Arg Cys Gly Phe Ser Ser
545                 550                 555                 560 
Ser Phe Gly Cys Asn Tyr Gly Met Glu Ser Arg His Arg Glu Leu Val
                565                 570                 575     
Val Pro Gln Leu Pro Ala Arg Lys Lys Val
            580                 585     


<210> 1477
<211> 1826
<212> PRT
<213> Homo sapiens

<400> 1477
Met Gly Asp Ser Lys Val Lys Val Ala Val Arg Ile Arg Pro Met Asn
 1               5                  10                  15      
Arg Arg Glu Thr Asp Leu His Thr Lys Cys Val Val Asp Val Asp Ala
            20                  25                  30          
Asn Lys Val Ile Leu Asn Pro Val Asn Thr Asn Leu Ser Lys Gly Asp
        35                  40                  45              
Ala Arg Gly Gln Pro Lys Cys Phe Ala Tyr Asp His Cys Phe Trp Ser
    50                  55                  60                  
Met Asp Glu Ser Val Lys Glu Lys Tyr Ala Gly Gln Asp Ile Val Phe
65                  70                  75                  80  
Lys Cys Leu Gly Glu Asn Ile Leu Gln Asn Ala Phe Asp Gly Tyr Asn
                85                  90                  95      
Ala Cys Ile Phe Ala Tyr Gly Gln Thr Gly Ser Gly Lys Ser Tyr Thr
            100                 105                 110         
Met Met Gly Thr Ala Asp Gln Pro Gly Leu Ile Pro Arg Leu Cys Ser
        115                 120                 125             
Gly Leu Phe Glu Arg Thr Gln Lys Glu Glu Asn Glu Glu Gln Ser Phe
    130                 135                 140                 
Lys Val Glu Val Ser Tyr Met Glu Ile Tyr Asn Glu Lys Val Arg Asp
145                 150                 155                 160 
Leu Leu Asp Pro Lys Gly Ser Arg Gln Thr Leu Lys Val Arg Glu His
                165                 170                 175     
Ser Val Leu Gly Pro Tyr Val Asp Gly Leu Ser Lys Leu Ala Ala Thr
            180                 185                 190         
Ser Tyr Lys Asp Ile Glu Ser Leu Met Ser Glu Gly Asn Lys Ser Arg
        195                 200                 205             
Thr Val Ala Ala Thr Asn Met Asn Glu Glu Ser Ser Arg Ser His Ala
    210                 215                 220                 
Val Leu Lys Ile Thr Leu Thr His Thr Leu Tyr Asp Ala Lys Ser Gly
225                 230                 235                 240 
Thr Ser Gly Glu Lys Val Gly Lys Leu Ser Leu Val Asp Leu Ala Gly
                245                 250                 255     
Ser Glu Arg Ala Thr Lys Thr Gly Ala Ala Gly Asp Arg Leu Lys Glu
            260                 265                 270         
Gly Ser Asn Ile Asn Glu Ser Leu Thr Thr Leu Gly Leu Val Ile Ser
        275                 280                 285             
Ala Leu Ala Asp Gln Ser Ala Gly Lys Asn Lys Asn Lys Phe Val Pro
    290                 295                 300                 
Tyr Arg Asp Ser Val Leu Thr Trp Leu Leu Lys Asp Ser Leu Gly Gly
305                 310                 315                 320 
Asn Ser Lys Thr Ala Met Val Ala Thr Val Ser Pro Ala Ala Asp Asn
                325                 330                 335     
Tyr Asp Glu Thr Leu Ser Thr Leu Arg Tyr Ala Asp Arg Ala Lys His
            340                 345                 350         
Ile Val Asn Asn Ala Val Val Asn Glu Asp Pro Asn Ala Arg Ile Ile
        355                 360                 365             
Arg Asp Leu Arg Glu Glu Val Glu Lys Leu Arg Glu Gln Leu Thr Lys
    370                 375                 380                 
Ala Glu Ala Met Lys Ser Pro Glu Leu Lys Asp Arg Leu Glu Glu Ser
385                 390                 395                 400 
Glu Lys Leu Ile Gln Glu Met Thr Val Thr Trp Glu Glu Lys Leu Arg
                405                 410                 415     
Lys Thr Glu Glu Ile Ala Gln Glu Arg Gln Lys Gln Leu Glu Ser Leu
            420                 425                 430         
Gly Ile Ser Leu Gln Ser Ser Gly Ile Lys Val Gly Asp Asp Lys Cys
        435                 440                 445             
Phe Leu Val Asn Leu Asn Ala Asp Pro Ala Leu Asn Glu Leu Leu Val
    450                 455                 460                 
Tyr Tyr Leu Lys Glu His Thr Leu Ile Gly Ser Ala Asn Ser Gln Asp
465                 470                 475                 480 
Ile Gln Leu Cys Gly Met Gly Ile Leu Pro Glu His Cys Ile Ile Asp
                485                 490                 495     
Ile Thr Ser Glu Gly Gln Val Met Leu Thr Pro Gln Lys Asn Thr Arg
            500                 505                 510         
Thr Phe Val Asn Gly Ser Ser Val Ser Ser Pro Ile Gln Leu His His
        515                 520                 525             
Gly Asp Arg Ile Leu Trp Gly Asn Asn His Phe Phe Arg Leu Asn Leu
    530                 535                 540                 
Pro Lys Lys Lys Lys Lys Ala Glu Arg Glu Asp Glu Asp Gln Asp Pro
545                 550                 555                 560 
Ser Met Lys Asn Glu Asn Ser Ser Glu Gln Leu Asp Val Asp Gly Asp
                565                 570                 575     
Ser Ser Ser Glu Val Ser Ser Glu Val Asn Phe Asn Tyr Glu Tyr Ala
            580                 585                 590         
Gln Met Glu Val Thr Met Lys Ala Leu Gly Ser Asn Asp Pro Met Gln
        595                 600                 605             
Ser Ile Leu Asn Ser Leu Glu Gln Gln His Glu Glu Glu Lys Arg Ser
    610                 615                 620                 
Ala Leu Glu Arg Gln Arg Leu Met Tyr Glu His Glu Leu Glu Gln Leu
625                 630                 635                 640 
Arg Arg Arg Leu Ser Pro Glu Lys Gln Asn Cys Arg Ser Met Asp Arg
                645                 650                 655     
Phe Ser Phe His Ser Pro Ser Ala Gln Gln Arg Leu Arg Gln Trp Ala
            660                 665                 670         
Glu Glu Arg Glu Ala Thr Leu Asn Asn Ser Leu Met Arg Leu Arg Glu
        675                 680                 685             
Gln Ile Val Lys Ala Asn Leu Leu Val Arg Glu Ala Asn Tyr Ile Ala
    690                 695                 700                 
Glu Glu Leu Asp Lys Arg Thr Glu Tyr Lys Val Thr Leu Gln Ile Pro
705                 710                 715                 720 
Ala Ser Ser Leu Asp Ala Asn Arg Lys Arg Gly Ser Leu Leu Ser Glu
                725                 730                 735     
Pro Ala Ile Gln Val Arg Arg Lys Gly Lys Gly Lys Gln Ile Trp Ser
            740                 745                 750         
Leu Glu Lys Leu Asp Asn Arg Leu Leu Asp Met Arg Asp Leu Tyr Gln
        755                 760                 765             
Glu Trp Lys Glu Cys Glu Glu Asp Asn Pro Val Ile Arg Ser Tyr Phe
    770                 775                 780                 
Lys Arg Ala Asp Pro Phe Tyr Asp Glu Gln Glu Asn Leu Ser Leu Ile
785                 790                 795                 800 
Gly Val Ala Asn Val Phe Leu Glu Ser Leu Phe Tyr Asp Val Lys Leu
                805                 810                 815     
Gln Tyr Ala Val Pro Ile Ile Asn Gln Lys Gly Glu Val Ala Gly Arg
            820                 825                 830         
Leu His Val Glu Val Met Arg Leu Ser Gly Asp Val Gly Glu Arg Ile
        835                 840                 845             
Ala Gly Gly Asp Glu Val Ala Glu Val Pro Phe Glu Lys Glu Thr Gln
    850                 855                 860                 
Glu Asn Lys Leu Val Cys Met Val Lys Ile Leu Gln Ala Thr Gly Leu
865                 870                 875                 880 
Pro Gln His Leu Ser His Phe Val Phe Cys Lys Tyr Ser Phe Trp Asp
                885                 890                 895     
Gln Gln Glu Pro Val Ile Val Ala Pro Glu Val Asp Thr Ser Ser Ser
            900                 905                 910         
Ser Val Ser Lys Glu Pro His Cys Met Val Val Phe Asp His Cys Asn
        915                 920                 925             
Glu Phe Ser Val Asn Ile Thr Glu Asp Phe Ile Glu His Leu Ser Glu
    930                 935                 940                 
Gly Ala Leu Ala Ile Glu Val Tyr Gly His Lys Ile Asn Asp Pro Arg
945                 950                 955                 960 
Lys Asn Pro Ala Leu Trp Asp Leu Gly Ile Ile Gln Ala Lys Thr Arg
                965                 970                 975     
Ser Leu Arg Asp Arg Trp Ser Glu Val Thr Arg Lys Leu Glu Phe Trp
            980                 985                 990         
Val Gln Ile Leu Glu Gln Asn Glu Asn Gly Glu Tyr Cys Pro Val Glu
        995                 1000                1005            
Val Ile Ser Ala Lys Asp Val Pro Thr Gly Gly Ile Phe Gln Leu Arg
    1010                1015                1020                
Gln Gly Gln Ser Arg Arg Val Gln Val Glu Val Lys Ser Val Gln Glu
1025                1030                1035                1040
Ser Gly Thr Leu Pro Leu Met Glu Glu Cys Ile Leu Ser Val Gly Ile
                1045                1050                1055    
Gly Cys Val Lys Val Arg Pro Leu Arg Ala Pro Arg Thr His Glu Thr
            1060                1065                1070        
Phe His Glu Glu Glu Glu Asp Met Asp Ser Tyr Gln Asp Arg Asp Leu
        1075                1080                1085            
Glu Arg Leu Arg Arg Lys Trp Leu Asn Ala Leu Thr Lys Arg Gln Glu
    1090                1095                1100                
Tyr Leu Asp Gln Gln Leu Gln Lys Leu Val Ser Lys Arg Asp Lys Thr
1105                1110                1115                1120
Glu Asp Asp Ala Asp Arg Glu Ala Gln Leu Leu Glu Met Arg Leu Thr
                1125                1130                1135    
Leu Thr Glu Glu Arg Asn Ala Val Met Val Pro Ser Ala Gly Ser Gly
            1140                1145                1150        
Ile Pro Gly Ala Pro Ala Glu Trp Thr Pro Val Pro Gly Met Glu Thr
        1155                1160                1165            
His Ile Pro Val Ile Phe Leu Asp Leu Asn Ala Asp Asp Phe Ser Ser
    1170                1175                1180                
Gln Asp Asn Leu Asp Asp Pro Glu Ala Gly Gly Trp Asp Ala Thr Leu
1185                1190                1195                1200
Thr Gly Glu Glu Glu Glu Glu Phe Phe Glu Leu Gln Ile Val Lys Gln
                1205                1210                1215    
His Asp Gly Glu Val Lys Ala Glu Ala Ser Trp Asp Ser Ala Val His
            1220                1225                1230        
Gly Cys Pro Gln Leu Ser Arg Gly Thr Pro Val Asp Glu Arg Leu Phe
        1235                1240                1245            
Leu Ile Val Arg Val Thr Val Gln Leu Ser His Pro Ala Asp Met Gln
    1250                1255                1260                
Leu Val Leu Arg Lys Arg Ile Cys Val Asn Val His Gly Arg Gln Gly
1265                1270                1275                1280
Phe Ala Gln Ser Leu Leu Lys Lys Met Ser His Arg Ser Ser Ile Pro
                1285                1290                1295    
Gly Cys Gly Val Thr Phe Glu Ile Val Ser Asn Ile Pro Glu Asp Ala
            1300                1305                1310        
Gln Gly Val Glu Glu Arg Glu Ala Leu Ala Arg Met Ala Ala Asn Val
        1315                1320                1325            
Glu Asn Pro Ala Ser Ala Asp Ser Glu Ala Tyr Ile Glu Lys Tyr Leu
    1330                1335                1340                
Arg Ser Val Leu Ala Val Glu Asn Leu Leu Thr Leu Asp Arg Leu Arg
1345                1350                1355                1360
Gln Glu Val Ala Val Lys Glu Gln Leu Thr Gly Lys Gly Lys Leu Ser
                1365                1370                1375    
Arg Arg Ser Ile Ser Ser Pro Asn Val Asn Arg Leu Ser Gly Ser Arg
            1380                1385                1390        
Gln Asp Leu Ile Pro Ser Tyr Ser Leu Gly Ser Asn Lys Gly Arg Trp
        1395                1400                1405            
Glu Ser Gln Gln Asp Val Ser Gln Thr Thr Val Ser Arg Gly Ile Ala
    1410                1415                1420                
Pro Ala Pro Ala Leu Ser Val Ser Pro Gln Asn Asn His Ser Pro Asp
1425                1430                1435                1440
Pro Gly Leu Ser Asn Leu Ala Ala Ser Tyr Leu Asn Pro Val Lys Ser
                1445                1450                1455    
Phe Val Pro Gln Met Pro Lys Leu Leu Lys Ser Leu Phe Pro Val Arg
            1460                1465                1470        
Asp Glu Lys Arg Gly Lys Arg Pro Ser Pro Leu Ala His Gln Pro Val
        1475                1480                1485            
Pro Arg Ile Met Val Gln Ser Ala Ser Pro Asp Ile Arg Val Thr Arg
    1490                1495                1500                
Met Glu Glu Ala Gln Pro Glu Met Gly Pro Asp Val Leu Val Gln Thr
1505                1510                1515                1520
Met Gly Ala Pro Ala Leu Lys Ile Cys Asp Lys Pro Ala Lys Val Pro
                1525                1530                1535    
Ser Pro Pro Pro Val Ile Ala Val Thr Ala Val Thr Pro Ala Pro Glu
            1540                1545                1550        
Ala Gln Asp Gly Pro Pro Ser Pro Leu Ser Glu Ala Ser Ser Gly Tyr
        1555                1560                1565            
Phe Ser His Ser Val Ser Thr Ala Thr Leu Ser Asp Ala Leu Gly Pro
    1570                1575                1580                
Gly Leu Asp Ala Ala Ala Pro Pro Gly Ser Met Pro Thr Ala Pro Glu
1585                1590                1595                1600
Ala Glu Pro Glu Ala Pro Ile Ser His Pro Pro Pro Pro Thr Ala Val
                1605                1610                1615    
Pro Ala Glu Glu Pro Pro Gly Pro Gln Gln Leu Val Ser Pro Gly Arg
            1620                1625                1630        
Glu Arg Pro Asp Leu Glu Ala Pro Ala Pro Gly Ser Pro Phe Arg Val
        1635                1640                1645            
Arg Arg Val Arg Ala Ser Glu Leu Arg Ser Phe Ser Arg Met Leu Ala
    1650                1655                1660                
Gly Asp Pro Gly Cys Ser Pro Gly Ala Glu Gly Asn Ala Pro Ala Pro
1665                1670                1675                1680
Gly Ala Gly Gly Gln Ala Leu Ala Ser Asp Ser Glu Glu Ala Asp Glu
                1685                1690                1695    
Val Pro Glu Trp Leu Arg Glu Gly Glu Phe Val Thr Val Gly Ala His
            1700                1705                1710        
Lys Thr Gly Val Val Arg Tyr Val Gly Pro Ala Asp Phe Gln Glu Gly
        1715                1720                1725            
Thr Trp Val Gly Val Glu Leu Asp Leu Pro Ser Gly Lys Asn Asp Gly
    1730                1735                1740                
Ser Ile Gly Gly Lys Gln Tyr Phe Arg Cys Asn Pro Gly Tyr Gly Leu
1745                1750                1755                1760
Leu Val Arg Pro Ser Arg Val Arg Arg Ala Thr Gly Pro Val Arg Arg
                1765                1770                1775    
Arg Ser Thr Gly Leu Arg Leu Gly Ala Pro Glu Ala Arg Arg Ser Ala
            1780                1785                1790        
Thr Leu Ser Gly Ser Ala Thr Asn Leu Ala Ser Leu Thr Ala Ala Leu
        1795                1800                1805            
Ala Lys Ala Asp Arg Ser His Lys Asn Pro Glu Asn Arg Lys Ser Trp
    1810                1815                1820                
Ala Ser
1825    


<210> 1478
<211> 190
<212> PRT
<213> Homo sapiens

<400> 1478
Met Ser Cys Gln Val Leu Gln Trp Gln Lys Gln His Gln Asn Asp Leu
 1               5                  10                  15      
Lys Met Leu Ala Ala Lys Glu Glu Gln Leu Arg Glu Phe Gln Glu Glu
            20                  25                  30          
Met Ala Ala Leu Lys Glu Asn Leu Leu Glu Asp Asp Lys Glu Pro Cys
        35                  40                  45              
Cys Leu Pro Gln Trp Ser Val Pro Lys Asp Thr Cys Arg Leu Tyr Arg
    50                  55                  60                  
Gly Asn Asp Gln Ile Met Thr Asn Leu Glu Gln Trp Ala Lys Gln Gln
65                  70                  75                  80  
Lys Val Ala Asn Glu Lys Leu Gly Asn Gln Leu Arg Glu Gln Val Asn
                85                  90                  95      
Tyr Ile Ala Lys Leu Ser Gly Glu Lys Asp His Leu His Ser Val Met
            100                 105                 110         
Val His Leu Gln Gln Glu Asn Lys Lys Leu Lys Lys Glu Ile Glu Glu
        115                 120                 125             
Lys Lys Met Lys Ala Glu Asn Thr Arg Leu Cys Thr Lys Ala Leu Gly
    130                 135                 140                 
Pro Ser Arg Thr Glu Ser Thr Gln Arg Glu Lys Val Cys Gly Thr Leu
145                 150                 155                 160 
Gly Trp Lys Gly Leu Pro Gln Asp Met Gly Gln Arg Met Asp Leu Thr
                165                 170                 175     
Lys Tyr Ile Gly Met Pro His Cys Pro Gly Ser Ser Tyr Cys
            180                 185                 190 


<210> 1479
<211> 329
<212> PRT
<213> Homo sapiens

<400> 1479
Met Ala Thr Gly Gln Lys Leu Met Arg Ala Val Arg Val Phe Glu Phe
 1               5                  10                  15      
Gly Gly Pro Glu Val Leu Lys Leu Arg Ser Asp Ile Ala Val Pro Ile
            20                  25                  30          
Pro Lys Asp His Gln Val Leu Ile Lys Val His Ala Cys Gly Val Asn
        35                  40                  45              
Pro Val Glu Thr Tyr Ile Arg Ser Gly Thr Tyr Ser Arg Lys Pro Leu
    50                  55                  60                  
Leu Pro Tyr Thr Pro Gly Ser Asp Val Ala Gly Val Ile Glu Ala Val
65                  70                  75                  80  
Gly Asp Asn Ala Ser Ala Phe Lys Lys Gly Asp Arg Val Phe Thr Ser
                85                  90                  95      
Ser Thr Ile Ser Gly Gly Tyr Ala Glu Tyr Ala Leu Ala Ala Asp His
            100                 105                 110         
Thr Val Tyr Lys Leu Pro Glu Lys Leu Asp Phe Lys Gln Gly Ala Ala
        115                 120                 125             
Ile Gly Ile Pro Tyr Phe Thr Ala Tyr Arg Ala Leu Ile His Ser Ala
    130                 135                 140                 
Cys Val Lys Ala Gly Glu Ser Val Leu Val His Gly Ala Ser Gly Gly
145                 150                 155                 160 
Val Gly Leu Ala Ala Cys Gln Ile Ala Arg Ala Tyr Gly Leu Lys Ile
                165                 170                 175     
Leu Gly Thr Ala Gly Thr Glu Glu Gly Gln Lys Ile Val Leu Gln Asn
            180                 185                 190         
Gly Ala His Glu Val Phe Asn His Arg Glu Val Asn Tyr Ile Asp Lys
        195                 200                 205             
Ile Lys Lys Tyr Val Gly Glu Lys Gly Ile Asp Ile Ile Ile Glu Met
    210                 215                 220                 
Leu Ala Asn Val Asn Leu Ser Lys Asp Leu Ser Leu Leu Ser His Gly
225                 230                 235                 240 
Gly Arg Val Ile Val Val Gly Ser Arg Gly Thr Ile Glu Ile Asn Pro
                245                 250                 255     
Arg Asp Thr Met Ala Lys Glu Ser Ser Ile Ile Gly Val Thr Leu Phe
            260                 265                 270         
Ser Ser Thr Lys Glu Glu Phe Gln Gln Tyr Ala Ala Ala Leu Gln Ala
        275                 280                 285             
Gly Met Glu Ile Gly Trp Leu Lys Pro Val Ile Gly Ser Gln Tyr Pro
    290                 295                 300                 
Leu Glu Lys Val Ala Glu Ala His Glu Asn Ile Ile His Gly Ser Gly
305                 310                 315                 320 
Ala Thr Gly Lys Met Ile Leu Leu Leu
                325                 


<210> 1480
<211> 263
<212> PRT
<213> Homo sapiens

<400> 1480
Met Phe Gly Ser Ser Arg Gly Gly Val Arg Gly Gly Gln Asp Gln Phe
 1               5                  10                  15      
Asn Trp Glu Asp Val Lys Thr Asp Lys Gln Arg Glu Asn Tyr Leu Gly
            20                  25                  30          
Asn Ser Leu Met Ala Pro Val Gly Arg Trp Gln Lys Gly Arg Asp Leu
        35                  40                  45              
Thr Trp Tyr Ala Lys Gly Arg Ala Pro Cys Ala Gly Pro Ser Arg Glu
    50                  55                  60                  
Glu Glu Leu Ala Ala Val Arg Glu Ala Glu Arg Glu Ala Leu Leu Ala
65                  70                  75                  80  
Ala Leu Gly Tyr Lys Asn Val Lys Lys Gln Pro Thr Gly Leu Ser Lys
                85                  90                  95      
Glu Asp Phe Ala Glu Val Cys Lys Arg Glu Gly Gly Asp Pro Glu Glu
            100                 105                 110         
Lys Gly Val Asp Arg Leu Leu Gly Leu Gly Ser Ala Ser Gly Ser Val
        115                 120                 125             
Gly Arg Val Ala Met Ser Arg Glu Asp Lys Glu Ala Ala Lys Leu Gly
    130                 135                 140                 
Leu Ser Val Phe Thr His His Arg Val Glu Ser Gly Gly Pro Gly Thr
145                 150                 155                 160 
Ser Ala Ala Ser Ala Arg Arg Lys Pro Arg Ala Glu Asp Gln Thr Glu
                165                 170                 175     
Ser Ser Cys Glu Ser His Arg Lys Ser Lys Lys Glu Lys Lys Lys Lys
            180                 185                 190         
Lys Lys Arg Lys His Lys Lys Glu Lys Lys Lys Lys Asp Lys Glu His
        195                 200                 205             
Arg Arg Pro Ala Glu Ala Thr Ser Ser Pro Thr Ser Pro Glu Arg Pro
    210                 215                 220                 
Arg His His His His Asp Ser Asp Ser Asn Ser Pro Cys Cys Lys Arg
225                 230                 235                 240 
Arg Lys Arg Gly His Ser Gly Asp Arg Arg Ser Pro Ser Arg Arg Trp
                245                 250                 255     
His Asp Arg Gly Ser Glu Ala
            260             


<210> 1481
<211> 1024
<212> PRT
<213> Homo sapiens

<400> 1481
Met Ala Glu Ala Pro Pro Val Ser Gly Thr Phe Lys Phe Asn Thr Asp
 1               5                  10                  15      
Ala Ala Glu Phe Ile Pro Gln Glu Lys Lys Asn Ser Gly Leu Asn Cys
            20                  25                  30          
Gly Thr Gln Arg Arg Leu Asp Ser Asn Arg Ile Gly Arg Arg Asn Tyr
        35                  40                  45              
Ser Ser Pro Pro Pro Cys His Leu Ser Arg Gln Val Pro Tyr Asp Glu
    50                  55                  60                  
Ile Ser Ala Val His Gln His Ser Tyr His Pro Ser Gly Ser Lys Pro
65                  70                  75                  80  
Lys Ser Gln Gln Thr Ser Phe Gln Ser Ser Pro Cys Asn Lys Ser Pro
                85                  90                  95      
Lys Ser His Gly Leu Gln Asn Gln Pro Trp Gln Lys Leu Arg Asn Glu
            100                 105                 110         
Lys His His Ile Arg Val Lys Lys Ala Gln Ser Leu Ala Glu Gln Thr
        115                 120                 125             
Ser Asp Thr Ala Gly Leu Glu Ser Ser Thr Arg Ser Glu Ser Gly Thr
    130                 135                 140                 
Asp Leu Arg Glu His Ser Pro Ser Glu Ser Glu Lys Glu Val Val Gly
145                 150                 155                 160 
Ala Asp Pro Arg Gly Ala Lys Pro Lys Lys Ala Thr Gln Phe Val Tyr
                165                 170                 175     
Ser Tyr Gly Arg Gly Pro Lys Val Lys Gly Lys Leu Lys Cys Glu Trp
            180                 185                 190         
Ser Asn Arg Thr Thr Pro Lys Pro Glu Asp Ala Gly Pro Glu Ser Thr
        195                 200                 205             
Lys Pro Val Gly Val Phe His Pro Asp Ser Ser Glu Ala Ser Ser Arg
    210                 215                 220                 
Lys Gly Val Leu Asp Gly Tyr Gly Ala Arg Arg Asn Glu Gln Arg Arg
225                 230                 235                 240 
Tyr Pro Gln Lys Arg Pro Pro Trp Glu Val Glu Gly Ala Arg Pro Arg
                245                 250                 255     
Pro Gly Arg Asn Pro Pro Lys Gln Glu Gly His Arg His Thr Asn Ala
            260                 265                 270         
Gly His Arg Asn Asn Met Gly Pro Ile Pro Lys Asp Asp Leu Asn Glu
        275                 280                 285             
Arg Pro Ala Lys Ser Thr Cys Asp Ser Glu Asn Leu Ala Val Ile Asn
    290                 295                 300                 
Lys Ser Ser Arg Arg Val Asp Gln Glu Lys Cys Thr Val Arg Arg Gln
305                 310                 315                 320 
Asp Pro Gln Val Val Ser Pro Phe Ser Arg Gly Lys Gln Asn His Val
                325                 330                 335     
Leu Lys Asn Val Glu Thr His Thr Gly Ser Leu Ile Glu Gln Leu Thr
            340                 345                 350         
Thr Glu Lys Tyr Glu Cys Met Val Cys Cys Glu Leu Val Arg Val Thr
        355                 360                 365             
Ala Pro Val Trp Ser Cys Gln Ser Cys Tyr His Val Phe His Leu Asn
    370                 375                 380                 
Cys Ile Lys Lys Trp Ala Arg Ser Pro Ala Ser Gln Ala Asp Gly Gln
385                 390                 395                 400 
Ser Gly Trp Arg Cys Pro Ala Cys Gln Asn Val Ser Ala His Val Pro
                405                 410                 415     
Asn Thr Tyr Thr Cys Phe Cys Gly Lys Val Lys Asn Pro Glu Trp Ser
            420                 425                 430         
Arg Asn Glu Ile Pro His Ser Cys Gly Glu Val Cys Arg Lys Lys Gln
        435                 440                 445             
Pro Gly Gln Asp Cys Pro His Ser Cys Asn Leu Leu Cys His Pro Gly
    450                 455                 460                 
Pro Cys Pro Pro Cys Pro Ala Phe Met Thr Lys Thr Cys Glu Cys Gly
465                 470                 475                 480 
Arg Thr Arg His Thr Val Arg Cys Gly Gln Ala Val Ser Val His Cys
                485                 490                 495     
Ser Asn Pro Cys Glu Asn Ile Leu Asn Cys Gly Gln His Gln Cys Ala
            500                 505                 510         
Glu Leu Cys His Gly Gly Gln Cys Gln Pro Cys Gln Ile Ile Leu Asn
        515                 520                 525             
Gln Val Cys Tyr Cys Gly Ser Thr Ser Arg Asp Val Leu Cys Gly Thr
    530                 535                 540                 
Asp Val Gly Lys Ser Asp Gly Phe Gly Asp Phe Ser Cys Leu Lys Ile
545                 550                 555                 560 
Cys Gly Lys Asp Leu Lys Cys Gly Asn His Thr Cys Ser Gln Val Cys
                565                 570                 575     
His Pro Gln Pro Cys Gln Gln Cys Pro Arg Leu Pro Gln Leu Val Arg
            580                 585                 590         
Cys Cys Pro Cys Gly Gln Thr Pro Leu Ser Gln Leu Leu Glu Leu Gly
        595                 600                 605             
Ser Ser Ser Arg Lys Thr Cys Met Asp Pro Val Pro Ser Cys Gly Lys
    610                 615                 620                 
Val Cys Gly Lys Pro Leu Pro Cys Gly Ser Leu Asp Phe Ile His Thr
625                 630                 635                 640 
Cys Glu Lys Leu Cys His Glu Gly Asp Cys Gly Pro Cys Ser Arg Thr
                645                 650                 655     
Ser Val Ile Ser Cys Arg Cys Ser Phe Arg Thr Lys Glu Leu Pro Cys
            660                 665                 670         
Thr Ser Leu Lys Ser Glu Asp Ala Thr Phe Met Cys Asp Lys Arg Cys
        675                 680                 685             
Asn Lys Lys Arg Leu Cys Gly Arg His Lys Cys Asn Glu Ile Cys Cys
    690                 695                 700                 
Val Asp Lys Glu His Lys Cys Pro Leu Ile Cys Gly Arg Lys Leu Arg
705                 710                 715                 720 
Cys Gly Leu His Arg Cys Glu Glu Pro Cys His Arg Gly Asn Cys Gln
                725                 730                 735     
Thr Cys Trp Gln Ala Ser Phe Asp Glu Leu Thr Cys His Cys Gly Ala
            740                 745                 750         
Ser Val Ile Tyr Pro Pro Val Pro Cys Gly Thr Arg Pro Pro Glu Cys
        755                 760                 765             
Thr Gln Thr Cys Ala Arg Val His Glu Cys Asp His Pro Val Tyr His
    770                 775                 780                 
Ser Cys His Ser Glu Glu Lys Cys Pro Pro Cys Thr Phe Leu Thr Gln
785                 790                 795                 800 
Lys Trp Cys Met Gly Lys His Glu Phe Arg Ser Asn Ile Pro Cys His
                805                 810                 815     
Leu Val Asp Ile Ser Cys Gly Leu Pro Cys Ser Ala Thr Leu Pro Cys
            820                 825                 830         
Gly Met His Lys Cys Gln Arg Leu Cys His Lys Gly Glu Cys Leu Val
        835                 840                 845             
Asp Glu Pro Cys Lys Gln Pro Cys Thr Thr Pro Arg Ala Asp Cys Gly
    850                 855                 860                 
His Pro Cys Met Ala Pro Cys His Thr Ser Ser Pro Cys Pro Val Thr
865                 870                 875                 880 
Ala Cys Lys Ala Lys Val Glu Leu Gln Cys Glu Cys Gly Arg Arg Lys
                885                 890                 895     
Glu Met Val Ile Cys Ser Glu Ala Ser Ser Thr Tyr Gln Arg Ile Ala
            900                 905                 910         
Ala Ile Ser Met Ala Ser Lys Ile Thr Asp Met Gln Leu Gly Gly Ser
        915                 920                 925             
Val Glu Ile Ser Lys Leu Ile Thr Lys Lys Glu Val His Gln Ala Arg
    930                 935                 940                 
Leu Glu Cys Asp Glu Glu Cys Ser Ala Leu Glu Arg Lys Lys Arg Leu
945                 950                 955                 960 
Ala Glu Ala Phe His Ile Ser Glu Asp Ser Asp Pro Phe Asn Ile Arg
                965                 970                 975     
Ser Ser Gly Ser Lys Phe Ser Asp Ser Leu Lys Glu Asp Ala Arg Lys
            980                 985                 990         
Asp Leu Lys Phe Val Ser Asp Val Glu Lys Glu Met Glu Thr Leu Val
        995                 1000                1005            
Glu Ala Val Asn Lys Val Glu Val Glu Thr Ser His Trp Thr Phe Leu
    1010                1015                1020                


<210> 1482
<211> 911
<212> PRT
<213> Homo sapiens

<400> 1482
Met Ala Glu Lys Ala Pro Pro Gly Leu Asn Arg Lys Thr Ser Arg Ser
 1               5                  10                  15      
Thr Leu Ser Leu Pro Pro Glu Pro Val Asp Ile Ile Arg Ser Lys Thr
            20                  25                  30          
Cys Ser Arg Arg Val Lys Ile Asn Val Gly Gly Leu Asn His Glu Val
        35                  40                  45              
Leu Trp Arg Thr Leu Asp Arg Leu Pro Arg Thr Arg Leu Gly Lys Leu
    50                  55                  60                  
Arg Asp Cys Asn Thr His Glu Ser Leu Leu Glu Val Cys Asp Asp Tyr
65                  70                  75                  80  
Asn Leu Asn Glu Asn Glu Tyr Phe Phe Asp Arg His Pro Gly Ala Phe
                85                  90                  95      
Thr Ser Ile Leu Asn Phe Tyr Arg Thr Gly Lys Leu His Met Met Glu
            100                 105                 110         
Glu Met Cys Ala Leu Ser Phe Gly Gln Glu Leu Asp Tyr Trp Gly Ile
        115                 120                 125             
Asp Glu Ile Tyr Leu Glu Ser Cys Cys Gln Ala Arg Tyr His Gln Lys
    130                 135                 140                 
Lys Glu Gln Met Asn Glu Glu Leu Arg Arg Glu Ala Glu Thr Met Arg
145                 150                 155                 160 
Glu Arg Glu Gly Glu Glu Phe Asp Asn Thr Cys Cys Pro Asp Lys Arg
                165                 170                 175     
Lys Lys Leu Trp Asp Leu Leu Glu Lys Pro Asn Ser Ser Val Ala Ala
            180                 185                 190         
Lys Ile Leu Ala Ile Val Ser Ile Leu Phe Ile Val Leu Ser Thr Ile
        195                 200                 205             
Ala Leu Ser Leu Asn Thr Leu Pro Glu Leu Gln Glu Thr Asp Glu Phe
    210                 215                 220                 
Gly Gln Leu Asn Asp Asn Arg Gln Leu Ala His Val Glu Ala Val Cys
225                 230                 235                 240 
Ile Ala Trp Phe Thr Met Glu Tyr Leu Leu Arg Phe Leu Ser Ser Pro
                245                 250                 255     
Asn Lys Trp Lys Phe Phe Lys Gly Pro Leu Asn Val Ile Asp Leu Leu
            260                 265                 270         
Ala Ile Leu Pro Tyr Tyr Val Thr Ile Phe Leu Thr Glu Ser Asn Lys
        275                 280                 285             
Ser Val Leu Gln Phe Gln Asn Val Arg Arg Val Val Gln Ile Phe Arg
    290                 295                 300                 
Ile Met Arg Ile Leu Arg Ile Leu Lys Leu Ala Arg His Ser Thr Gly
305                 310                 315                 320 
Leu Gln Ser Leu Gly Phe Thr Leu Arg Arg Ser Tyr Asn Glu Leu Gly
                325                 330                 335     
Leu Leu Ile Leu Phe Leu Ala Met Gly Ile Met Ile Phe Ser Ser Leu
            340                 345                 350         
Val Phe Phe Ala Glu Lys Asp Glu Asp Ala Thr Lys Phe Thr Ser Ile
        355                 360                 365             
Pro Ala Ser Phe Trp Trp Ala Thr Ile Thr Met Thr Thr Val Gly Tyr
    370                 375                 380                 
Gly Asp Ile Tyr Pro Lys Thr Leu Leu Gly Lys Ile Val Gly Gly Leu
385                 390                 395                 400 
Cys Cys Ile Ala Gly Val Leu Val Ile Ala Leu Pro Ile Pro Ile Ile
                405                 410                 415     
Val Asn Asn Phe Ser Glu Phe Tyr Lys Glu Gln Lys Arg Gln Glu Lys
            420                 425                 430         
Ala Ile Lys Arg Arg Glu Ala Leu Glu Arg Ala Lys Arg Asn Gly Ser
        435                 440                 445             
Ile Val Ser Met Asn Leu Lys Asp Ala Phe Ala Arg Ser Met Glu Leu
    450                 455                 460                 
Ile Asp Val Ala Val Glu Lys Ala Gly Glu Ser Ala Asn Thr Lys Asp
465                 470                 475                 480 
Ser Ala Asp Asp Asn His Leu Ser Pro Ser Arg Trp Lys Trp Ala Arg
                485                 490                 495     
Lys Ala Leu Ser Glu Thr Ser Ser Asn Lys Ser Phe Glu Asn Lys Tyr
            500                 505                 510         
Gln Glu Val Ser Gln Lys Asp Ser His Glu Gln Leu Asn Asn Thr Ser
        515                 520                 525             
Ser Ser Ser Pro Gln His Leu Ser Ala Gln Lys Leu Glu Met Leu Tyr
    530                 535                 540                 
Asn Glu Ile Thr Lys Thr Gln Pro His Ser His Pro Asn Pro Asp Cys
545                 550                 555                 560 
Gln Glu Lys Pro Glu Arg Pro Ser Ala Tyr Glu Glu Glu Ile Glu Met
                565                 570                 575     
Glu Glu Val Val Cys Pro Gln Glu Gln Leu Ala Val Ala Gln Thr Glu
            580                 585                 590         
Val Ile Val Asp Met Lys Ser Thr Ser Ser Ile Asp Ser Phe Thr Ser
        595                 600                 605             
Cys Ala Thr Asp Phe Thr Glu Thr Glu Arg Ser Pro Leu Pro Pro Pro
    610                 615                 620                 
Ser Ala Ser His Leu Gln Met Lys Phe Pro Thr Asp Leu Pro Gly Thr
625                 630                 635                 640 
Glu Glu His Gln Arg Ala Arg Gly Pro Pro Phe Leu Thr Leu Ser Arg
                645                 650                 655     
Glu Lys Gly Pro Ala Ala Arg Asp Gly Thr Leu Glu Tyr Ala Pro Val
            660                 665                 670         
Asp Ile Thr Val Asn Leu Asp Ala Ser Gly Ser Gln Cys Gly Leu His
        675                 680                 685             
Ser Pro Leu Gln Ser Asp Asn Ala Thr Asp Ser Pro Lys Ser Ser Leu
    690                 695                 700                 
Lys Gly Ser Asn Pro Leu Lys Ser Arg Ser Leu Lys Val Asn Phe Lys
705                 710                 715                 720 
Glu Asn Arg Gly Ser Ala Pro Gln Thr Pro Pro Ser Thr Ala Arg Pro
                725                 730                 735     
Leu Pro Val Thr Thr Ala Asp Phe Ser Leu Thr Thr Pro Gln His Ile
            740                 745                 750         
Ser Thr Ile Leu Leu Glu Glu Thr Pro Ser Gln Gly Asp Arg Pro Leu
        755                 760                 765             
Leu Gly Thr Glu Val Ser Ala Pro Cys Gln Gly Pro Ser Lys Gly Leu
    770                 775                 780                 
Ser Pro Arg Phe Pro Lys Gln Lys Leu Phe Pro Phe Ser Ser Arg Glu
785                 790                 795                 800 
Arg Arg Ser Phe Thr Glu Ile Asp Thr Gly Asp Asp Glu Asp Phe Leu
                805                 810                 815     
Glu Leu Pro Gly Ala Arg Glu Glu Lys Gln Val Asp Ser Ser Pro Asn
            820                 825                 830         
Cys Phe Ala Asp Lys Pro Ser Asp Gly Arg Asp Pro Leu Arg Glu Glu
        835                 840                 845             
Gly Ser Val Gly Ser Ser Ser Pro Gln Asp Thr Gly His Asn Cys Arg
    850                 855                 860                 
Gln Asp Ile Tyr His Ala Val Ser Glu Val Lys Lys Asp Ser Ser Gln
865                 870                 875                 880 
Glu Gly Cys Lys Met Glu Asn His Leu Phe Ala Pro Glu Ile His Ser
                885                 890                 895     
Asn Pro Gly Asp Thr Gly Tyr Cys Pro Thr Arg Glu Thr Ser Met
            900                 905                 910     


<210> 1483
<211> 117
<212> PRT
<213> Homo sapiens

<400> 1483
Met Ser Asn Lys Phe Leu Gly Thr Trp Lys Leu Val Ser Ser Glu Asn
 1               5                  10                  15      
Phe Asp Asp Tyr Met Lys Ala Leu Gly Gly Val Gly Leu Ala Thr Arg
            20                  25                  30          
Lys Leu Gly Asn Leu Ala Lys Pro Thr Val Ile Ile Ser Lys Lys Gly
        35                  40                  45              
Asp Ile Ile Thr Ile Arg Thr Glu Ser Thr Phe Lys Asn Thr Glu Ile
    50                  55                  60                  
Ser Phe Lys Leu Gly Gln Glu Phe Glu Glu Thr Thr Ala Asp Asn Arg
65                  70                  75                  80  
Lys Thr Lys Ser Ile Val Thr Leu Gln Arg Gly Ser Leu Asn Gln Val
                85                  90                  95      
Gln Arg Trp Asp Gly Lys Glu Thr Thr Ile Lys Arg Lys Leu Val Asn
            100                 105                 110         
Gly Lys Met Val Ala
        115         


<210> 1484
<211> 968
<212> PRT
<213> Homo sapiens

<400> 1484
Met Lys Phe Phe Val Phe Lys Ser Phe Leu Ser Asp Cys Tyr Arg Ser
 1               5                  10                  15      
Leu Leu Asp Lys Ser Gln Leu Pro Ala Pro Arg Ser Arg Leu Pro Ala
            20                  25                  30          
Pro Gly Ala Arg Arg Gly Ala Val Pro Gln Thr Thr Arg Ser Arg Gly
        35                  40                  45              
Gly Trp Val Trp Gly Arg Gly Ser Gln Cys Arg Arg Ile Gly Pro Gln
    50                  55                  60                  
Ser Ala Val Leu Leu Ser Pro Glu Ala Ala Trp Met Glu Pro Pro Leu
65                  70                  75                  80  
Pro Val Gly Ala Gln Pro Leu Ala Thr Val Glu Gly Met Glu Met Lys
                85                  90                  95      
Gly Pro Leu Arg Glu Pro Cys Ala Leu Thr Leu Ala Gln Arg Asn Gly
            100                 105                 110         
Gln Tyr Glu Leu Ile Ile Gln Leu His Glu Lys Glu Gln His Val Gln
        115                 120                 125             
Asp Ile Ile Pro Ile Asn Ser His Phe Arg Cys Val Gln Glu Ala Glu
    130                 135                 140                 
Glu Thr Leu Leu Ile Asp Ile Ala Ser Asn Ser Gly Cys Lys Ile Arg
145                 150                 155                 160 
Val Gln Gly Asp Trp Ile Arg Glu Arg Arg Phe Glu Ile Pro Asp Glu
                165                 170                 175     
Glu His Cys Leu Lys Phe Leu Ser Ala Val Leu Ala Ala Gln Lys Ala
            180                 185                 190         
Gln Ser Gln Leu Leu Val Pro Glu Gln Lys Asp Ser Ser Ser Trp Tyr
        195                 200                 205             
Gln Lys Leu Asp Thr Lys Asp Lys Pro Ser Val Phe Ser Gly Leu Leu
    210                 215                 220                 
Gly Phe Glu Asp Asn Phe Ser Ser Met Asn Leu Asp Lys Lys Ile Asn
225                 230                 235                 240 
Ser Gln Asn Gln Pro Thr Gly Ile His Arg Glu Pro Pro Pro Pro Pro
                245                 250                 255     
Phe Ser Val Asn Lys Met Leu Pro Arg Glu Lys Glu Ala Ser Asn Lys
            260                 265                 270         
Glu Gln Pro Lys Val Thr Asn Thr Met Arg Lys Leu Phe Val Pro Asn
        275                 280                 285             
Thr Gln Ser Gly Gln Arg Glu Gly Leu Ile Lys His Ile Leu Ala Lys
    290                 295                 300                 
Arg Glu Lys Glu Tyr Val Asn Ile Gln Thr Phe Arg Phe Phe Val Gly
305                 310                 315                 320 
Thr Trp Asn Val Asn Gly Gln Ser Pro Asp Ser Gly Leu Glu Pro Trp
                325                 330                 335     
Leu Asn Cys Asp Pro Asn Pro Pro Asp Ile Tyr Cys Ile Gly Phe Gln
            340                 345                 350         
Glu Leu Asp Leu Ser Thr Glu Ala Phe Phe Tyr Phe Glu Ser Val Lys
        355                 360                 365             
Glu Gln Glu Trp Ser Met Ala Val Glu Arg Gly Leu His Ser Lys Ala
    370                 375                 380                 
Lys Tyr Lys Lys Val Gln Leu Val Arg Leu Val Gly Met Met Leu Leu
385                 390                 395                 400 
Ile Phe Ala Arg Lys Asp Gln Cys Arg Tyr Ile Arg Asp Ile Ala Thr
                405                 410                 415     
Glu Thr Val Gly Thr Gly Ile Met Gly Lys Met Gly Asn Lys Gly Gly
            420                 425                 430         
Val Ala Val Arg Phe Val Phe His Asn Thr Thr Phe Cys Ile Val Asn
        435                 440                 445             
Ser His Leu Ala Ala His Val Glu Asp Phe Glu Arg Arg Asn Gln Asp
    450                 455                 460                 
Tyr Lys Asp Ile Cys Ala Arg Met Ser Phe Val Val Pro Asn Gln Thr
465                 470                 475                 480 
Leu Pro Gln Leu Asn Ile Met Lys His Glu Val Val Ile Trp Leu Gly
                485                 490                 495     
Asp Leu Asn Tyr Arg Leu Cys Met Pro Asp Ala Asn Glu Val Lys Ser
            500                 505                 510         
Leu Ile Asn Lys Lys Asp Leu Gln Arg Leu Leu Lys Phe Asp Gln Leu
        515                 520                 525             
Asn Ile Gln Arg Thr Gln Lys Lys Ala Phe Val Asp Phe Asn Glu Gly
    530                 535                 540                 
Glu Ile Lys Phe Ile Pro Thr Tyr Lys Tyr Asp Ser Lys Thr Asp Arg
545                 550                 555                 560 
Trp Asp Ser Ser Gly Lys Cys Arg Val Pro Ala Trp Cys Asp Arg Ile
                565                 570                 575     
Leu Trp Arg Gly Thr Asn Val Asn Gln Leu Asn Tyr Arg Ser His Met
            580                 585                 590         
Glu Leu Lys Thr Ser Asp His Lys Pro Val Ser Ala Leu Phe His Ile
        595                 600                 605             
Gly Val Lys Val Val Asp Glu Arg Arg Tyr Arg Lys Val Phe Glu Asp
    610                 615                 620                 
Ser Val Arg Ile Met Asp Arg Met Glu Asn Asp Phe Leu Pro Ser Leu
625                 630                 635                 640 
Glu Leu Ser Arg Arg Glu Phe Val Phe Glu Asn Val Lys Phe Arg Gln
                645                 650                 655     
Leu Gln Lys Glu Lys Phe Gln Ile Ser Asn Asn Gly Gln Val Pro Cys
            660                 665                 670         
His Phe Ser Phe Ile Pro Lys Leu Asn Asp Ser Gln Tyr Cys Lys Pro
        675                 680                 685             
Trp Leu Arg Ala Glu Pro Phe Glu Gly Tyr Leu Glu Pro Asn Glu Thr
    690                 695                 700                 
Val Asp Ile Ser Leu Asp Val Tyr Val Ser Lys Asp Ser Val Thr Ile
705                 710                 715                 720 
Leu Asn Ser Gly Glu Asp Lys Ile Glu Asp Ile Leu Val Leu His Leu
                725                 730                 735     
Asp Arg Gly Lys Asp Tyr Phe Leu Thr Ile Ser Gly Asn Tyr Leu Pro
            740                 745                 750         
Ser Cys Phe Gly Thr Ser Leu Glu Ala Leu Cys Arg Met Lys Arg Pro
        755                 760                 765             
Ile Arg Glu Val Pro Val Thr Lys Leu Ile Asp Leu Glu Lys Ser Leu
    770                 775                 780                 
Leu Gln Met Val Pro Leu Asp Glu Gly Ala Ser Glu Arg Pro Leu Gln
785                 790                 795                 800 
Val Pro Lys Glu Ile Trp Leu Leu Val Asp His Leu Phe Lys Tyr Ala
                805                 810                 815     
Cys His Gln Glu Asp Leu Phe Gln Thr Pro Gly Met Gln Glu Glu Leu
            820                 825                 830         
Gln Gln Ile Ile Asp Cys Leu Asp Thr Ser Ile Pro Glu Thr Ile Pro
        835                 840                 845             
Gly Ser Asn His Ser Val Ala Glu Ala Leu Leu Ile Phe Leu Glu Ala
    850                 855                 860                 
Leu Pro Glu Pro Val Ile Cys Tyr Glu Leu Tyr Gln Arg Cys Leu Asp
865                 870                 875                 880 
Ser Ala Tyr Asp Pro Arg Ile Cys Arg Gln Val Ile Ser Gln Leu Pro
                885                 890                 895     
Arg Cys His Arg Asn Val Phe Arg Tyr Leu Met Ala Phe Leu Arg Glu
            900                 905                 910         
Leu Leu Lys Phe Ser Glu Tyr Asn Ser Val Asn Ala Asn Met Ile Ala
        915                 920                 925             
Thr Leu Phe Thr Ser Leu Leu Leu Arg Pro Pro Pro Asn Leu Met Ala
    930                 935                 940                 
Arg Gln Thr Pro Ser Asp Arg Gln Arg Ala Ile Gln Phe Leu Leu Gly
945                 950                 955                 960 
Phe Leu Leu Gly Ser Glu Glu Asp
                965             


<210> 1485
<211> 782
<212> PRT
<213> Homo sapiens

<400> 1485
Met Ala Glu Glu Ser Ser Ser Ser Ser Ser Ser Ser Ser Pro Thr Ala
 1               5                  10                  15      
Ala Thr Ser Gln Gln Gln Gln Leu Lys Asn Lys Ser Ile Leu Ile Ser
            20                  25                  30          
Ser Val Ala Ser Val His His Ala Asn Gly Leu Ala Lys Ser Ser Thr
        35                  40                  45              
Thr Val Ser Ser Phe Ala Asn Ser Lys Pro Gly Ser Ala Lys Asn Leu
    50                  55                  60                  
Val Ile Lys Asn Phe Lys Asp Lys Pro Lys Leu Pro Glu Asn Tyr Thr
65                  70                  75                  80  
Asp Glu Thr Trp Gln Lys Leu Lys Glu Ala Val Glu Ala Ile Gln Asn
                85                  90                  95      
Ser Thr Ser Ile Lys Tyr Asn Leu Glu Glu Leu Tyr Gln Ala Val Glu
            100                 105                 110         
Asn Leu Cys Ser Tyr Lys Ile Ser Ala Asn Leu Tyr Lys Gln Leu Arg
        115                 120                 125             
Gln Ile Cys Glu Asp His Met Lys Ala Gln Ile His Gln Phe Arg Glu
    130                 135                 140                 
Asp Ser Leu Asp Ser Val Leu Phe Leu Lys Lys Ile Asp Arg Cys Trp
145                 150                 155                 160 
Gln Asn His Cys Arg Gln Met Ile Met Ile Arg Ser Ile Phe Leu Phe
                165                 170                 175     
Leu Asp Arg Thr Tyr Val Leu Gln Asn Ser Met Leu Pro Ser Ile Trp
            180                 185                 190         
Asp Met Gly Leu Glu Leu Phe Arg Ala His Ile Ile Ser Asp Gln Lys
        195                 200                 205             
Val Gln Asn Lys Thr Ile Asp Gly Ile Leu Leu Leu Ile Glu Arg Glu
    210                 215                 220                 
Arg Asn Gly Glu Ala Ile Asp Arg Ser Leu Leu Arg Ser Leu Leu Ser
225                 230                 235                 240 
Met Leu Ser Asp Leu Gln Ile Tyr Gln Asp Ser Phe Glu Gln Arg Phe
                245                 250                 255     
Leu Glu Glu Thr Asn Arg Leu Tyr Ala Ala Glu Gly Gln Lys Leu Met
            260                 265                 270         
Gln Glu Arg Glu Val Pro Glu Tyr Leu His His Val Asn Lys Arg Leu
        275                 280                 285             
Glu Glu Glu Ala Asp Arg Leu Ile Thr Tyr Leu Asp Gln Thr Thr Gln
    290                 295                 300                 
Lys Ser Leu Ile Ala Thr Val Glu Lys Gln Leu Leu Gly Glu His Leu
305                 310                 315                 320 
Thr Ala Ile Leu Gln Lys Gly Leu Asn Asn Leu Leu Asp Glu Asn Arg
                325                 330                 335     
Ile Gln Asp Leu Ser Leu Leu Tyr Gln Leu Phe Ser Arg Val Arg Gly
            340                 345                 350         
Gly Val Gln Val Leu Leu Gln Gln Trp Ile Glu Tyr Ile Lys Ala Phe
        355                 360                 365             
Gly Ser Thr Ile Val Ile Asn Pro Glu Lys Asp Lys Thr Met Val Gln
    370                 375                 380                 
Glu Leu Leu Asp Phe Lys Asp Lys Val Asp His Ile Ile Asp Ile Cys
385                 390                 395                 400 
Phe Leu Lys Asn Glu Lys Phe Ile Asn Ala Met Lys Glu Ala Phe Glu
                405                 410                 415     
Thr Phe Ile Asn Lys Arg Pro Asn Lys Pro Ala Glu Leu Ile Ala Lys
            420                 425                 430         
Tyr Val Asp Ser Lys Leu Arg Ala Gly Asn Lys Glu Ala Thr Asp Glu
        435                 440                 445             
Glu Leu Glu Lys Met Leu Asp Lys Ile Met Ile Ile Phe Arg Phe Ile
    450                 455                 460                 
Tyr Gly Lys Asp Val Phe Glu Ala Phe Tyr Lys Lys Asp Leu Ala Lys
465                 470                 475                 480 
Arg Leu Leu Val Gly Lys Ser Ala Ser Val Asp Ala Glu Lys Ser Met
                485                 490                 495     
Leu Ser Lys Leu Lys His Glu Cys Gly Ala Ala Phe Thr Ser Lys Leu
            500                 505                 510         
Glu Gly Met Phe Lys Asp Met Glu Leu Ser Lys Asp Ile Met Ile Gln
        515                 520                 525             
Phe Lys Gln Val Lys Tyr Met Gln Asn Gln Asn Val Pro Gly Asn Ile
    530                 535                 540                 
Glu Leu Thr Val Asn Ile Leu Thr Met Gly Tyr Trp Pro Thr Tyr Val
545                 550                 555                 560 
Pro Met Glu Val His Leu Pro Pro Glu Met Val Lys Leu Gln Glu Ile
                565                 570                 575     
Phe Lys Thr Phe Tyr Leu Gly Lys His Ser Gly Arg Lys Leu Gln Trp
            580                 585                 590         
Gln Ser Thr Leu Gly His Cys Val Leu Lys Ala Glu Phe Lys Glu Gly
        595                 600                 605             
Lys Lys Glu Leu Gln Val Ser Leu Phe Gln Thr Leu Val Leu Leu Met
    610                 615                 620                 
Phe Asn Glu Gly Glu Glu Phe Ser Leu Glu Glu Ile Lys Gln Ala Thr
625                 630                 635                 640 
Gly Ile Glu Asp Gly Glu Leu Arg Arg Thr Leu Gln Ser Leu Ala Cys
                645                 650                 655     
Gly Lys Ala Arg Val Leu Ala Lys Asn Pro Lys Gly Lys Asp Ile Glu
            660                 665                 670         
Asp Gly Asp Lys Phe Ile Cys Asn Asp Asp Phe Lys His Lys Leu Phe
        675                 680                 685             
Arg Ile Lys Ile Asn Gln Ile Gln Met Lys Glu Thr Val Glu Glu Gln
    690                 695                 700                 
Ala Ser Thr Thr Glu Arg Val Phe Gln Asp Arg Gln Tyr Gln Ile Asp
705                 710                 715                 720 
Ala Ala Ile Val Arg Ile Met Lys Met Arg Lys Thr Leu Ser His Asn
                725                 730                 735     
Leu Leu Val Ser Glu Val Tyr Asn Gln Leu Lys Phe Pro Val Lys Pro
            740                 745                 750         
Ala Asp Leu Lys Lys Arg Ile Glu Ser Leu Ile Asp Arg Asp Tyr Met
        755                 760                 765             
Glu Arg Asp Lys Glu Asn Pro Asn Gln Tyr Asn Tyr Ile Ala
    770                 775                 780         


<210> 1486
<211> 1257
<212> PRT
<213> Homo sapiens

<400> 1486
Met Lys Ala Ala Asp Glu Pro Ala Tyr Leu Thr Val Gly Thr Asp Val
 1               5                  10                  15      
Ser Ala Lys Tyr Arg Gly Ala Phe Cys Glu Ala Lys Ile Lys Thr Val
            20                  25                  30          
Lys Arg Leu Val Lys Val Lys Val Leu Leu Lys Gln Asp Asn Thr Thr
        35                  40                  45              
Gln Leu Val Gln Asp Asp Gln Val Lys Gly Pro Leu Arg Val Gly Ala
    50                  55                  60                  
Ile Val Glu Thr Arg Thr Ser Asp Gly Ser Phe Gln Glu Ala Ile Ile
65                  70                  75                  80  
Ser Lys Leu Thr Asp Ala Ser Trp Tyr Thr Val Val Phe Asp Asp Gly
                85                  90                  95      
Asp Glu Arg Thr Leu Arg Arg Thr Ser Leu Cys Leu Lys Gly Glu Arg
            100                 105                 110         
His Phe Ala Glu Ser Glu Thr Leu Asp Gln Leu Pro Leu Thr Asn Pro
        115                 120                 125             
Glu His Phe Gly Thr Pro Val Ile Ala Lys Lys Thr Asn Arg Gly Arg
    130                 135                 140                 
Arg Ser Ser Leu Pro Val Thr Glu Asp Glu Lys Glu Glu Glu Ser Ser
145                 150                 155                 160 
Glu Glu Glu Asp Glu Asp Lys Arg Arg Leu Asn Asp Glu Leu Leu Gly
                165                 170                 175     
Lys Val Val Ser Val Val Ser Ala Thr Glu Arg Thr Glu Trp Tyr Pro
            180                 185                 190         
Ala Leu Val Ile Ser Pro Ser Cys Asn Asp Asp Ile Thr Val Lys Lys
        195                 200                 205             
Asp Gln Cys Leu Val Arg Ser Phe Ile Asp Ser Lys Phe Tyr Ser Ile
    210                 215                 220                 
Ala Arg Lys Asp Ile Lys Glu Val Asp Ile Leu Asn Leu Pro Glu Ser
225                 230                 235                 240 
Glu Leu Ser Thr Lys Pro Gly Leu Gln Lys Ala Ser Ile Phe Leu Lys
                245                 250                 255     
Thr Arg Val Val Pro Asp Asn Trp Lys Met Asp Ile Ser Glu Ile Leu
            260                 265                 270         
Glu Ser Ser Ser Ser Asp Asp Glu Asp Gly Pro Ala Glu Glu Asn Asp
        275                 280                 285             
Glu Glu Lys Glu Lys Glu Ala Lys Lys Thr Glu Glu Glu Val Pro Glu
    290                 295                 300                 
Glu Glu Leu Asp Pro Glu Glu Arg Asp Asn Phe Leu Gln Gln Leu Tyr
305                 310                 315                 320 
Lys Phe Met Glu Asp Arg Gly Thr Pro Ile Asn Lys Pro Pro Val Leu
                325                 330                 335     
Gly Tyr Lys Asp Leu Asn Leu Phe Lys Leu Phe Arg Leu Val Tyr His
            340                 345                 350         
Gln Gly Gly Cys Asp Asn Ile Asp Ser Gly Ala Val Trp Lys Gln Ile
        355                 360                 365             
Tyr Met Asp Leu Gly Ile Pro Ile Leu Asn Ser Ala Ala Ser Tyr Asn
    370                 375                 380                 
Val Lys Thr Ala Tyr Arg Lys Tyr Leu Tyr Gly Phe Glu Glu Tyr Cys
385                 390                 395                 400 
Arg Ser Ala Asn Ile Gln Phe Arg Thr Val His His His Glu Pro Lys
                405                 410                 415     
Val Lys Glu Glu Lys Lys Asp Leu Glu Glu Ser Met Glu Glu Ala Leu
            420                 425                 430         
Lys Leu Asp Gln Glu Met Pro Leu Thr Glu Val Lys Ser Glu Pro Glu
        435                 440                 445             
Glu Asn Ile Asp Ser Asn Ser Glu Ser Glu Arg Glu Glu Ile Glu Leu
    450                 455                 460                 
Lys Ser Pro Arg Gly Arg Arg Arg Ile Ala Arg Asp Val Asn Ser Ile
465                 470                 475                 480 
Lys Lys Glu Ile Glu Glu Glu Lys Thr Glu Asp Lys Leu Lys Asp Asn
                485                 490                 495     
Asp Thr Glu Asn Lys Asp Val Asp Asp Asp Tyr Glu Thr Ala Glu Lys
            500                 505                 510         
Lys Glu Asn Glu Leu Leu Leu Gly Arg Lys Asn Thr Pro Lys Gln Lys
        515                 520                 525             
Glu Lys Lys Ile Lys Lys Gln Glu Asp Ser Asp Lys Asp Ser Asp Glu
    530                 535                 540                 
Glu Glu Glu Lys Ser Gln Glu Arg Glu Glu Thr Glu Ser Lys Cys Asp
545                 550                 555                 560 
Ser Glu Gly Glu Glu Asp Glu Glu Asp Met Glu Pro Cys Leu Thr Gly
                565                 570                 575     
Thr Lys Val Lys Val Lys Tyr Gly Arg Gly Lys Thr Gln Lys Ile Tyr
            580                 585                 590         
Glu Ala Ser Ile Lys Ser Thr Glu Ile Asp Asp Gly Glu Val Leu Tyr
        595                 600                 605             
Leu Val His Tyr Tyr Gly Trp Asn Val Arg Tyr Asp Glu Trp Val Lys
    610                 615                 620                 
Ala Asp Arg Ile Ile Trp Pro Leu Asp Lys Gly Gly Pro Lys Lys Lys
625                 630                 635                 640 
Gln Lys Lys Lys Ala Lys Asn Lys Glu Asp Ser Glu Val Asp Glu Lys
                645                 650                 655     
Arg Asp Glu Glu Arg Gln Lys Ser Lys Arg Gly Arg Pro Pro Leu Lys
            660                 665                 670         
Ser Thr Leu Ser Ser Asn Met Pro Tyr Gly Leu Ser Lys Thr Ala Asn
        675                 680                 685             
Ser Glu Gly Lys Ser Asp Ser Cys Ser Ser Asp Ser Glu Thr Glu Asp
    690                 695                 700                 
Ala Leu Glu Lys Asn Leu Ile Asn Glu Glu Leu Ser Leu Lys Asp Glu
705                 710                 715                 720 
Leu Glu Lys Asn Glu Asn Leu Asn Asp Asp Lys Leu Asp Glu Glu Asn
                725                 730                 735     
Pro Lys Ile Ser Ala His Ile Leu Lys Glu Asn Asp Arg Thr Gln Met
            740                 745                 750         
Gln Pro Leu Glu Thr Leu Lys Leu Glu Val Gly Glu Asn Glu Gln Ile
        755                 760                 765             
Val Gln Ile Phe Gly Asn Lys Met Glu Lys Thr Glu Glu Val Lys Lys
    770                 775                 780                 
Glu Ala Glu Lys Ser Pro Lys Gly Lys Gly Arg Arg Ser Lys Thr Lys
785                 790                 795                 800 
Asp Leu Ser Leu Glu Ile Ile Lys Ile Ser Ser Phe Gly Gln Asn Glu
                805                 810                 815     
Ala Gly Ser Glu Pro His Ile Glu Ala His Ser Leu Glu Leu Ser Ser
            820                 825                 830         
Leu Asp Asn Lys Asn Phe Ser Ser Ala Thr Glu Asp Glu Ile Asp Gln
        835                 840                 845             
Cys Val Lys Glu Lys Lys Leu Lys Arg Lys Ile Leu Gly Gln Ser Ser
    850                 855                 860                 
Pro Glu Lys Lys Ile Arg Ile Glu Asn Gly Met Glu Met Thr Asn Thr
865                 870                 875                 880 
Val Ser Gln Glu Arg Thr Ser Asp Cys Ile Gly Ser Glu Gly Met Lys
                885                 890                 895     
Asn Leu Asn Phe Glu Gln His Phe Glu Arg Glu Asn Glu Gly Met Pro
            900                 905                 910         
Ser Leu Ile Ala Glu Ser Asn Gln Cys Ile Gln Gln Leu Thr Ser Glu
        915                 920                 925             
Arg Phe Asp Ser Pro Ala Glu Glu Thr Val Asn Ile Pro Leu Lys Glu
    930                 935                 940                 
Asp Glu Asp Ala Met Pro Leu Ile Gly Pro Glu Thr Leu Val Cys His
945                 950                 955                 960 
Glu Val Asp Leu Asp Asp Leu Asp Glu Lys Asp Lys Thr Ser Ile Glu
                965                 970                 975     
Asp Val Ala Val Glu Ser Ser Glu Ser Asn Ser Leu Val Ser Ile Pro
            980                 985                 990         
Pro Ala Leu Pro Pro Val Val Gln His Asn Phe Ser Val Ala Ser Pro
        995                 1000                1005            
Leu Thr Leu Ser Gln Asp Glu Ser Arg Ser Val Lys Ser Glu Ser Asp
    1010                1015                1020                
Ile Thr Ile Glu Val Asp Ser Ile Ala Glu Glu Ser Gln Glu Gly Leu
1025                1030                1035                1040
Cys Glu Arg Glu Ser Ala Asn Gly Phe Glu Thr Asn Val Ala Ser Gly
                1045                1050                1055    
Thr Cys Ser Ile Ile Val Gln Glu Arg Glu Ser Arg Glu Lys Gly Gln
            1060                1065                1070        
Lys Arg Pro Ser Asp Gly Asn Ser Gly Leu Met Ala Lys Lys Gln Lys
        1075                1080                1085            
Arg Thr Pro Lys Arg Thr Ser Ala Ala Ala Lys Asn Glu Lys Asn Gly
    1090                1095                1100                
Thr Gly Gln Ser Ser Asp Ser Glu Asp Leu Pro Val Leu Asp Asn Ser
1105                1110                1115                1120
Ser Lys Cys Thr Pro Val Lys His Leu Asn Val Ser Lys Pro Gln Lys
                1125                1130                1135    
Leu Ala Arg Ser Pro Ala Arg Ile Ser Pro His Ile Lys Asp Gly Glu
            1140                1145                1150        
Lys Asp Lys His Arg Glu Lys His Pro Asn Ser Ser Pro Arg Thr Tyr
        1155                1160                1165            
Lys Trp Ser Phe Gln Leu Asn Glu Leu Asp Asn Met Asn Ser Thr Glu
    1170                1175                1180                
Arg Ile Ser Phe Leu Gln Glu Lys Leu Gln Glu Ile Arg Lys Tyr Tyr
1185                1190                1195                1200
Met Ser Leu Lys Ser Glu Val Ala Thr Ile Asp Arg Arg Arg Lys Arg
                1205                1210                1215    
Leu Lys Lys Lys Asp Arg Glu Val Ser His Ala Gly Ala Ser Met Ser
            1220                1225                1230        
Ser Ala Ser Ser Asp Thr Gly Met Ser Pro Ser Ser Ser Ser Pro Pro
        1235                1240                1245            
Gln Asn Val Leu Ala Val Glu Cys Arg
    1250                1255        


<210> 1487
<211> 603
<212> PRT
<213> Homo sapiens

<400> 1487
Met Thr Met His Thr Thr Met Ala Thr Leu Thr Leu Thr Ser Leu Ile
 1               5                  10                  15      
Pro Pro Ile Leu Thr Thr Leu Val Asn Pro Asn Lys Lys Asn Ser Tyr
            20                  25                  30          
Pro His Tyr Val Lys Ser Ile Val Ala Ser Thr Phe Ile Ile Ser Leu
        35                  40                  45              
Phe Pro Thr Thr Met Phe Met Cys Leu Asp Gln Glu Val Ile Ile Ser
    50                  55                  60                  
Asn Trp His Trp Ala Thr Thr Gln Thr Thr Gln Leu Ser Leu Ser Phe
65                  70                  75                  80  
Lys Leu Asp Tyr Phe Ser Met Met Phe Ile Pro Val Ala Leu Phe Val
                85                  90                  95      
Thr Trp Ser Ile Met Glu Phe Ser Leu Trp Tyr Met Asn Ser Asp Pro
            100                 105                 110         
Asn Ile Asn Gln Phe Phe Lys Tyr Leu Leu Ile Phe Leu Ile Thr Met
        115                 120                 125             
Leu Ile Leu Val Thr Ala Asn Asn Leu Phe Gln Leu Phe Ile Gly Trp
    130                 135                 140                 
Glu Gly Val Gly Ile Met Ser Phe Leu Leu Ile Ser Trp Trp Tyr Ala
145                 150                 155                 160 
Arg Ala Asp Ala Asn Thr Ala Ala Ile Gln Ala Ile Leu Tyr Asn Arg
                165                 170                 175     
Ile Gly Asp Ile Gly Phe Ile Leu Ala Leu Ala Trp Phe Ile Leu His
            180                 185                 190         
Ser Asn Ser Trp Asp Pro Gln Gln Met Ala Leu Leu Asn Ala Asn Pro
        195                 200                 205             
Ser Leu Thr Pro Leu Leu Gly Leu Leu Leu Ala Ala Ala Gly Lys Ser
    210                 215                 220                 
Ala Gln Leu Gly Leu His Pro Trp Leu Pro Ser Ala Met Glu Gly Pro
225                 230                 235                 240 
Thr Pro Val Ser Ala Leu Leu His Ser Ser Thr Met Val Val Ala Gly
                245                 250                 255     
Ile Phe Leu Leu Ile Arg Phe His Pro Leu Ala Glu Asn Ser Pro Leu
            260                 265                 270         
Ile Gln Thr Leu Thr Leu Cys Leu Gly Ala Ile Thr Thr Leu Phe Ala
        275                 280                 285             
Ala Val Cys Ala Leu Thr Gln Asn Asp Ile Lys Lys Ile Val Ala Phe
    290                 295                 300                 
Ser Thr Ser Ser Gln Leu Gly Leu Met Met Val Thr Ile Gly Ile Asn
305                 310                 315                 320 
Gln Pro His Leu Ala Phe Leu His Ile Cys Thr His Ala Phe Phe Lys
                325                 330                 335     
Ala Met Leu Phe Met Cys Ser Gly Ser Ile Ile His Asn Leu Asn Asn
            340                 345                 350         
Glu Gln Asp Ile Arg Lys Met Gly Gly Leu Leu Lys Thr Met Pro Leu
        355                 360                 365             
Thr Ser Thr Ser Leu Thr Ile Gly Ser Leu Ala Leu Ala Gly Met Pro
    370                 375                 380                 
Phe Leu Thr Gly Phe Tyr Ser Lys Asp His Ile Ile Glu Thr Ala Asn
385                 390                 395                 400 
Met Ser Tyr Thr Asn Ala Trp Ala Leu Ser Ile Thr Leu Ile Ala Thr
                405                 410                 415     
Ser Leu Thr Gly Ala Tyr Ser Thr Arg Met Ile Leu Leu Thr Leu Thr
            420                 425                 430         
Gly Gln Pro Arg Phe Pro Thr Leu Thr Asn Ile Asn Glu Asn Asn Pro
        435                 440                 445             
Thr Leu Leu Asn Pro Ile Lys Arg Leu Ala Ala Gly Ser Leu Phe Ala
    450                 455                 460                 
Gly Phe Leu Ile Thr Asn Asn Ile Ser Pro Ala Ser Pro Phe Gln Thr
465                 470                 475                 480 
Thr Ile Pro Leu Tyr Leu Lys Leu Thr Ala Leu Ala Val Thr Phe Leu
                485                 490                 495     
Gly Leu Leu Thr Ala Leu Asp Leu Asn Tyr Leu Thr Asn Lys Leu Lys
            500                 505                 510         
Met Lys Ser Pro Leu Cys Thr Phe Tyr Phe Ser Asn Met Leu Gly Phe
        515                 520                 525             
Tyr Pro Ser Ile Thr His Arg Thr Ile Pro Tyr Leu Gly Leu Leu Thr
    530                 535                 540                 
Ser Gln Asn Leu Pro Leu Leu Leu Leu Asp Leu Thr Trp Leu Glu Lys
545                 550                 555                 560 
Leu Leu Pro Lys Thr Ile Ser Gln His Gln Ile Ser Thr Ser Ile Ile
                565                 570                 575     
Thr Ser Thr Gln Lys Gly Met Ile Lys Leu Tyr Phe Leu Ser Phe Phe
            580                 585                 590         
Phe Pro Leu Ile Leu Thr Leu Leu Leu Ile Thr
        595                 600             


<210> 1488
<211> 174
<212> PRT
<213> Homo sapiens

<400> 1488
Met Met Tyr Ala Leu Phe Leu Leu Ser Val Gly Leu Val Met Gly Phe
 1               5                  10                  15      
Val Gly Phe Ser Ser Lys Pro Ser Pro Ile Tyr Gly Gly Leu Val Leu
            20                  25                  30          
Ile Val Ser Gly Val Val Gly Cys Val Ile Ile Leu Asn Phe Gly Gly
        35                  40                  45              
Gly Tyr Met Gly Leu Met Val Phe Leu Ile Tyr Leu Gly Gly Met Met
    50                  55                  60                  
Val Val Phe Gly Tyr Thr Thr Ala Met Ala Ile Glu Glu Tyr Pro Glu
65                  70                  75                  80  
Ala Trp Gly Ser Gly Val Glu Val Leu Val Ser Val Leu Val Gly Leu
                85                  90                  95      
Gly Met Glu Val Gly Leu Val Leu Trp Val Lys Glu Tyr Asp Gly Val
            100                 105                 110         
Val Val Val Val Asn Phe Asn Ser Val Gly Ser Trp Met Ile Tyr Glu
        115                 120                 125             
Gly Glu Gly Ser Gly Leu Ile Arg Glu Asp Pro Ile Gly Ala Gly Ala
    130                 135                 140                 
Leu Tyr Asp Tyr Gly Arg Trp Leu Val Val Val Thr Gly Trp Thr Leu
145                 150                 155                 160 
Phe Val Gly Val Tyr Ile Val Ile Glu Ile Ala Arg Gly Asn
                165                 170                 


<210> 1489
<211> 603
<212> PRT
<213> Homo sapiens

<400> 1489
Met Thr Met His Thr Thr Met Thr Thr Leu Thr Leu Thr Ser Leu Ile
 1               5                  10                  15      
Pro Pro Ile Leu Thr Thr Leu Val Asn Pro Asn Lys Lys Asn Ser Tyr
            20                  25                  30          
Pro His Tyr Val Lys Ser Ile Val Ala Ser Thr Phe Ile Ile Ser Leu
        35                  40                  45              
Phe Pro Thr Thr Met Phe Met Cys Leu Asp Gln Glu Val Ile Ile Ser
    50                  55                  60                  
Asn Trp His Trp Ala Thr Thr Gln Thr Thr Gln Leu Ser Leu Ser Phe
65                  70                  75                  80  
Lys Leu Asp Tyr Phe Ser Met Met Phe Ile Pro Val Ala Leu Phe Val
                85                  90                  95      
Thr Trp Ser Ile Met Glu Phe Ser Leu Trp Tyr Met Asn Ser Asp Pro
            100                 105                 110         
Asn Ile Asn Gln Phe Phe Lys Tyr Leu Leu Ile Phe Leu Ile Thr Met
        115                 120                 125             
Leu Ile Leu Val Thr Ala Asn Asn Leu Phe Gln Leu Phe Ile Gly Trp
    130                 135                 140                 
Glu Gly Val Gly Ile Met Ser Phe Leu Leu Ile Ser Trp Trp Tyr Ala
145                 150                 155                 160 
Arg Ala Asp Ala Asn Thr Ala Ala Ile Gln Ala Ile Leu Tyr Asn Arg
                165                 170                 175     
Ile Gly Asp Ile Gly Phe Ile Leu Ala Leu Ala Trp Phe Ile Leu His
            180                 185                 190         
Ser Asn Ser Trp Asp Pro Gln Gln Met Ala Leu Leu Asn Ala Asn Pro
        195                 200                 205             
Ser Leu Thr Pro Leu Leu Gly Leu Leu Leu Ala Ala Ala Gly Lys Ser
    210                 215                 220                 
Ala Gln Leu Gly Leu His Pro Trp Leu Pro Ser Ala Met Glu Gly Pro
225                 230                 235                 240 
Thr Pro Val Ser Ala Leu Leu His Ser Ser Thr Met Val Val Ala Gly
                245                 250                 255     
Ile Phe Leu Leu Ile Arg Phe His Pro Leu Ala Glu Asn Asn Pro Leu
            260                 265                 270         
Ile Gln Thr Leu Thr Leu Cys Leu Gly Ala Ile Thr Thr Leu Phe Ala
        275                 280                 285             
Ala Val Cys Ala Leu Thr Gln Asn Asp Ile Lys Lys Ile Val Ala Phe
    290                 295                 300                 
Ser Thr Ser Ser Gln Leu Gly Leu Met Met Val Thr Ile Gly Ile Asn
305                 310                 315                 320 
Gln Pro His Leu Ala Phe Leu His Ile Cys Thr His Ala Phe Phe Lys
                325                 330                 335     
Ala Met Leu Phe Met Cys Ser Gly Ser Ile Ile His Asn Leu Asn Asn
            340                 345                 350         
Glu Gln Asp Ile Arg Lys Met Gly Gly Leu Leu Lys Thr Met Pro Leu
        355                 360                 365             
Thr Ser Thr Ser Leu Thr Ile Gly Ser Leu Ala Leu Ala Gly Met Pro
    370                 375                 380                 
Phe Leu Thr Gly Phe Tyr Ser Lys Asp His Ile Ile Glu Thr Ala Asn
385                 390                 395                 400 
Met Ser Tyr Thr Asn Ala Trp Ala Leu Ser Ile Thr Leu Ile Ala Thr
                405                 410                 415     
Ser Leu Thr Ser Ala Tyr Ser Thr Arg Met Ile Leu Leu Thr Leu Thr
            420                 425                 430         
Gly Gln Pro Arg Phe Pro Thr Leu Thr Asp Ile Asn Glu Asn Asn Pro
        435                 440                 445             
Thr Leu Leu Asn Pro Ile Lys Arg Leu Ala Ala Gly Ser Leu Phe Ala
    450                 455                 460                 
Gly Phe Leu Ile Thr Asn Asn Ile Ser Pro Ala Ser Pro Phe Gln Thr
465                 470                 475                 480 
Thr Ile Pro Leu Tyr Leu Lys Leu Thr Ala Leu Ala Val Thr Phe Leu
                485                 490                 495     
Gly Leu Leu Thr Ala Leu Asp Leu Asn Tyr Leu Thr Asn Lys Leu Lys
            500                 505                 510         
Met Lys Ser Pro Leu Cys Thr Phe Tyr Phe Ser Asn Met Leu Gly Phe
        515                 520                 525             
Tyr Pro Ser Ile Thr His Arg Thr Ile Pro Tyr Leu Gly Leu Leu Thr
    530                 535                 540                 
Ser Gln Asn Leu Pro Leu Leu Leu Leu Asp Leu Thr Trp Leu Glu Lys
545                 550                 555                 560 
Leu Leu Pro Lys Thr Ile Ser Gln His Gln Ile Ser Thr Ser Ile Ile
                565                 570                 575     
Thr Ser Thr Gln Lys Gly Met Ile Lys Leu Tyr Phe Leu Ser Phe Phe
            580                 585                 590         
Phe Pro Leu Ile Leu Thr Leu Leu Leu Ile Thr
        595                 600             


<210> 1490
<211> 318
<212> PRT
<213> Homo sapiens

<400> 1490
Met Pro Met Thr Asn Leu Leu Leu Leu Ile Val Pro Ile Leu Ile Ala
 1               5                  10                  15      
Met Ala Phe Leu Met Leu Thr Glu Arg Lys Ile Leu Gly Tyr Met Gln
            20                  25                  30          
Leu Arg Lys Gly Pro Asn Val Val Gly Pro Tyr Gly Leu Leu Gln Pro
        35                  40                  45              
Phe Ala Asp Ala Met Lys Leu Phe Thr Lys Glu Pro Leu Lys Pro Ala
    50                  55                  60                  
Thr Ser Thr Ile Thr Leu Tyr Ile Thr Ala Pro Thr Leu Ala Leu Thr
65                  70                  75                  80  
Ile Ala Leu Leu Leu Trp Thr Pro Leu Pro Met Pro Asn Pro Leu Val
                85                  90                  95      
Asn Leu Asn Leu Gly Leu Leu Phe Ile Leu Ala Thr Ser Ser Leu Ala
            100                 105                 110         
Val Tyr Ser Ile Leu Trp Ser Gly Trp Ala Ser Asn Ser Asn Tyr Ala
        115                 120                 125             
Leu Ile Gly Ala Leu Arg Ala Val Ala Gln Thr Ile Ser Tyr Glu Val
    130                 135                 140                 
Thr Leu Ala Ile Ile Leu Leu Ser Thr Leu Leu Met Ser Gly Ser Phe
145                 150                 155                 160 
Asn Leu Ser Thr Leu Ile Thr Thr Gln Glu His Leu Trp Leu Leu Leu
                165                 170                 175     
Pro Ser Trp Pro Leu Ala Met Met Trp Phe Ile Ser Thr Leu Ala Glu
            180                 185                 190         
Thr Asn Arg Thr Pro Phe Asp Leu Ala Glu Gly Glu Ser Glu Leu Val
        195                 200                 205             
Ser Gly Phe Asn Ile Glu Tyr Ala Ala Gly Pro Phe Ala Leu Phe Phe
    210                 215                 220                 
Met Ala Glu Tyr Thr Asn Ile Ile Met Met Asn Thr Leu Thr Thr Thr
225                 230                 235                 240 
Ile Phe Leu Gly Thr Thr Tyr Asp Ala Leu Ser Pro Glu Leu Tyr Thr
                245                 250                 255     
Thr Tyr Phe Val Thr Lys Thr Leu Leu Leu Thr Ser Leu Phe Leu Trp
            260                 265                 270         
Ile Arg Thr Ala Tyr Pro Arg Phe Arg Tyr Asp Gln Leu Met His Leu
        275                 280                 285             
Leu Trp Lys Asn Phe Leu Pro Leu Thr Leu Ala Leu Leu Met Trp Tyr
    290                 295                 300                 
Val Ser Met Pro Ile Thr Ile Ser Ser Ile Pro Pro Gln Thr
305                 310                 315             


<210> 1491
<211> 68
<212> PRT
<213> Homo sapiens

<400> 1491
Met Pro Gln Leu Asn Thr Thr Val Trp Pro Thr Met Ile Thr Pro Met
 1               5                  10                  15      
Phe Leu Thr Leu Phe Leu Ile Thr Gln Leu Lys Met Leu Asn Thr Asn
            20                  25                  30          
Tyr His Leu Pro Pro Ser Pro Lys Pro Met Lys Met Lys Asn Tyr Asn
        35                  40                  45              
Lys Pro Trp Glu Pro Lys Trp Thr Lys Ile Cys Ser Leu His Ser Leu
    50                  55                  60                  
Pro Pro Gln Ser
65              


<210> 1492
<211> 227
<212> PRT
<213> Homo sapiens

<400> 1492
Met Ala His Ala Ala Gln Val Gly Leu Gln Asp Ala Thr Ser Pro Ile
 1               5                  10                  15      
Met Glu Glu Leu Ile Thr Phe His Asp His Ala Leu Met Val Ile Phe
            20                  25                  30          
Leu Ile Cys Phe Leu Val Leu Tyr Ala Leu Phe Leu Thr Leu Thr Thr
        35                  40                  45              
Lys Leu Thr Asn Thr Asn Ile Ser Asp Ala Gln Glu Met Glu Thr Val
    50                  55                  60                  
Trp Thr Ile Leu Pro Ala Ile Ile Leu Val Leu Ile Ala Leu Pro Ser
65                  70                  75                  80  
Leu Arg Ile Leu Tyr Met Thr Asp Glu Val Asn Asp Pro Ser Leu Thr
                85                  90                  95      
Ile Lys Ser Ile Gly His Gln Trp Tyr Trp Thr Tyr Glu Tyr Thr Asp
            100                 105                 110         
Tyr Gly Gly Leu Ile Phe Asn Ser Tyr Met Leu Pro Pro Leu Phe Leu
        115                 120                 125             
Glu Pro Gly Asp Leu Arg Leu Leu Asp Val Asp Asn Arg Val Val Leu
    130                 135                 140                 
Pro Ile Glu Ala Pro Ile Arg Met Met Ile Thr Ser Gln Asp Val Leu
145                 150                 155                 160 
His Ser Trp Ala Val Pro Thr Leu Gly Leu Lys Thr Asp Ala Ile Pro
                165                 170                 175     
Gly Arg Leu Asn Gln Thr Thr Phe Thr Ala Thr Arg Pro Gly Val Tyr
            180                 185                 190         
Tyr Gly Gln Cys Ser Glu Ile Cys Gly Ala Asn His Ser Phe Met Pro
        195                 200                 205             
Ile Val Leu Glu Leu Ile Pro Leu Lys Ile Phe Glu Met Gly Pro Val
    210                 215                 220                 
Phe Thr Leu
225         


<210> 1493
<211> 1028
<212> PRT
<213> Homo sapiens

<400> 1493
Ala Phe Leu His Arg Ile Arg Gln Asn Val Ala Asp Ser Val Glu Lys
 1               5                  10                  15      
Gly Leu Thr Glu Glu Asn Val Lys Val Leu Phe Ser Asn Ile Glu Asp
            20                  25                  30          
Ile Leu Glu Val His Lys Asp Phe Leu Ala Ala Leu Glu Tyr Cys Leu
        35                  40                  45              
His Pro Glu Pro Gln Ser Gln His Glu Leu Gly Asn Val Phe Leu Lys
    50                  55                  60                  
Phe Lys Asp Lys Phe Cys Val Tyr Glu Glu Tyr Cys Ser Asn His Glu
65                  70                  75                  80  
Lys Ala Leu Arg Leu Leu Val Glu Leu Asn Lys Ile Pro Thr Val Arg
                85                  90                  95      
Ala Phe Leu Leu Ser Cys Met Leu Leu Gly Gly Arg Lys Thr Thr Asp
            100                 105                 110         
Ile Pro Leu Glu Gly Tyr Leu Leu Ser Pro Ile Gln Arg Ile Cys Lys
        115                 120                 125             
Tyr Pro Leu Leu Leu Lys Glu Leu Ala Lys Arg Thr Pro Gly Lys His
    130                 135                 140                 
Pro Asp His Pro Ala Val Gln Ser Ala Leu Gln Ala Met Lys Thr Val
145                 150                 155                 160 
Cys Ser Asn Ile Asn Glu Thr Lys Arg Gln Met Glu Lys Leu Glu Ala
                165                 170                 175     
Leu Glu Gln Leu Gln Ser His Ile Glu Gly Trp Glu Gly Ser Asn Leu
            180                 185                 190         
Thr Asp Ile Cys Thr Gln Leu Leu Leu Gln Gly Thr Leu Leu Lys Ile
        195                 200                 205             
Ser Ala Gly Asn Ile Gln Glu Arg Ala Phe Phe Leu Phe Asp Asn Leu
    210                 215                 220                 
Leu Val Tyr Cys Lys Arg Lys Ser Arg Val Thr Gly Ser Lys Lys Ser
225                 230                 235                 240 
Thr Lys Arg Thr Lys Ser Ile Asn Gly Ser Leu Tyr Ile Phe Arg Gly
                245                 250                 255     
Arg Ile Asn Thr Glu Val Met Glu Val Glu Asn Val Glu Asp Gly Thr
            260                 265                 270         
Ala Asp Tyr His Ser Asn Gly Tyr Thr Val Thr Asn Gly Trp Lys Ile
        275                 280                 285             
His Asn Thr Ala Lys Asn Lys Trp Phe Val Cys Met Ala Lys Thr Ala
    290                 295                 300                 
Glu Glu Lys Gln Lys Trp Leu Asp Ala Ile Ile Arg Glu Arg Glu Gln
305                 310                 315                 320 
Arg Glu Ser Leu Lys Leu Gly Met Glu Arg Asp Ala Tyr Val Met Ile
                325                 330                 335     
Ala Glu Lys Gly Glu Lys Leu Tyr His Met Met Met Asn Lys Lys Val
            340                 345                 350         
Asn Leu Ile Lys Asp Arg Arg Arg Lys Leu Ser Thr Val Pro Lys Cys
        355                 360                 365             
Phe Leu Gly Asn Glu Phe Val Ala Trp Leu Leu Glu Ile Gly Glu Ile
    370                 375                 380                 
Ser Lys Thr Glu Glu Gly Val Asn Leu Gly Gln Ala Leu Leu Glu Asn
385                 390                 395                 400 
Gly Ile Ile His His Val Ser Asp Lys His Gln Phe Lys Asn Glu Gln
                405                 410                 415     
Val Met Tyr Arg Phe Arg Tyr Asp Asp Gly Thr Tyr Lys Ala Arg Ser
            420                 425                 430         
Glu Leu Glu Asp Ile Met Ser Lys Gly Val Arg Leu Tyr Cys Arg Leu
        435                 440                 445             
His Ser Leu Tyr Thr Pro Val Ile Lys Asp Arg Asp Tyr His Leu Lys
    450                 455                 460                 
Thr Tyr Lys Ser Val Leu Pro Gly Ser Lys Leu Val Asp Trp Leu Leu
465                 470                 475                 480 
Ala Gln Gly Asp Cys Gln Thr Arg Glu Glu Ala Val Ala Leu Gly Val
                485                 490                 495     
Gly Leu Cys Asn Asn Gly Phe Met His His Val Leu Glu Lys Ser Glu
            500                 505                 510         
Phe Arg Asp Glu Ser Gln Tyr Phe Arg Phe His Ala Asp Glu Glu Met
        515                 520                 525             
Glu Gly Thr Ser Ser Lys Asn Lys Gln Leu Arg Asn Asp Phe Lys Leu
    530                 535                 540                 
Val Glu Asn Ile Leu Ala Lys Arg Leu Leu Ile Leu Pro Gln Glu Glu
545                 550                 555                 560 
Asp Tyr Gly Phe Asp Ile Glu Glu Lys Asn Lys Ala Val Val Val Lys
                565                 570                 575     
Ser Val Gln Arg Gly Ser Leu Ala Glu Val Ala Gly Leu Gln Val Gly
            580                 585                 590         
Arg Lys Ile Tyr Ser Ile Asn Glu Asp Leu Val Phe Leu Arg Pro Phe
        595                 600                 605             
Ser Glu Val Glu Ser Ile Leu Asn Gln Ser Phe Cys Ser Arg Arg Pro
    610                 615                 620                 
Leu Arg Leu Leu Val Ala Thr Lys Ala Lys Glu Ile Ile Lys Ile Pro
625                 630                 635                 640 
Asp Gln Pro Asp Thr Leu Cys Phe Gln Ile Arg Gly Ala Ala Pro Pro
                645                 650                 655     
Tyr Val Tyr Ala Val Gly Arg Gly Ser Glu Ala Met Ala Ala Gly Leu
            660                 665                 670         
Cys Ala Gly Gln Cys Ile Leu Lys Val Asn Gly Ser Asn Val Met Asn
        675                 680                 685             
Asp Gly Ala Pro Glu Val Leu Glu His Phe Gln Ala Phe Arg Ser Arg
    690                 695                 700                 
Arg Glu Glu Ala Leu Gly Leu Tyr Gln Trp Ile Tyr His Thr His Glu
705                 710                 715                 720 
Asp Ala Gln Glu Ala Arg Ala Ser Gln Glu Ala Ser Thr Glu Asp Pro
                725                 730                 735     
Ser Gly Glu Gln Ala Gln Glu Glu Asp Gln Ala Asp Ser Ala Phe Pro
            740                 745                 750         
Leu Leu Ser Leu Gly Pro Arg Leu Ser Leu Cys Glu Asp Ser Pro Met
        755                 760                 765             
Val Thr Leu Thr Val Asp Asn Val His Leu Glu His Gly Val Val Tyr
    770                 775                 780                 
Glu Tyr Val Ser Thr Ala Gly Val Arg Cys His Val Leu Glu Lys Ile
785                 790                 795                 800 
Val Glu Pro Arg Gly Cys Phe Gly Leu Thr Ala Lys Ile Leu Glu Ala
                805                 810                 815     
Phe Ala Ala Asn Asp Ser Val Phe Val Glu Asn Cys Arg Arg Leu Met
            820                 825                 830         
Ala Leu Ser Ser Ala Ile Val Thr Met Pro His Phe Glu Phe Arg Asn
        835                 840                 845             
Ile Cys Asp Thr Lys Leu Glu Ser Ile Gly Gln Arg Ile Ala Cys Tyr
    850                 855                 860                 
Gln Glu Phe Ala Ala Gln Leu Lys Ser Arg Val Ser Pro Pro Phe Lys
865                 870                 875                 880 
Gln Ala Pro Leu Glu Pro His Pro Leu Cys Gly Leu Asp Phe Cys Pro
                885                 890                 895     
Thr Asn Cys His Ile Asn Leu Met Glu Val Ser Tyr Pro Lys Thr Thr
            900                 905                 910         
Pro Ser Val Gly Arg Ser Phe Ser Ile Arg Phe Gly Arg Lys Pro Ser
        915                 920                 925             
Leu Ile Gly Leu Asp Pro Glu Gln Gly His Leu Asn Pro Met Ser Tyr
    930                 935                 940                 
Thr Gln His Cys Ile Thr Thr Met Ala Ala Pro Ser Trp Lys Cys Leu
945                 950                 955                 960 
Pro Ala Ala Glu Gly Asp Pro Gln Gly Gln Gly Leu His Asp Gly Ser
                965                 970                 975     
Phe Gly Pro Ala Ser Gly Thr Leu Gly Gln Glu Asp Arg Gly Leu Ser
            980                 985                 990         
Phe Leu Leu Lys Gln Glu Asp Arg Glu Ile Gln Asp Ala Tyr Leu Gln
        995                 1000                1005            
Leu Phe Thr Lys Leu Asp Val Ala Leu Lys Glu Met Lys Gln Tyr Val
    1010                1015                1020                
Thr Gln Ile Asn
1025            


<210> 1494
<211> 289
<212> PRT
<213> Homo sapiens

<400> 1494
Met Pro Val Asp Asn Arg Asn His Asn Glu Gly Met Val Thr Arg Cys
 1               5                  10                  15      
Ile Ile Glu Val Leu Ser Asn Ala Leu Ser Lys Ser Ser Ala Pro Pro
            20                  25                  30          
Ile Thr Pro Glu Cys Arg Gln Val Leu Lys Thr Ser Arg Lys Asp Val
        35                  40                  45              
Lys Asp Lys Glu Thr Thr Glu Asn Glu Asn Thr Lys Phe Glu Val Arg
    50                  55                  60                  
Leu Leu Arg Asp Pro Ala Asp Ala Ser Glu Ala His Glu Ser Ser Ser
65                  70                  75                  80  
Arg Gly Glu Ala Gly Ala Pro Gly Glu Glu Asp Ile Gln Gly Pro Thr
                85                  90                  95      
Lys Ala Asp Thr Glu Lys Trp Ala Glu Gly Gly Gly His Ser Arg Glu
            100                 105                 110         
Arg Ala Asp Glu Pro Gln Trp Ser Leu Tyr Pro Ser Asp Ser Gln Val
        115                 120                 125             
Ser Glu Glu Val Lys Thr Arg His Ser Glu Lys Ser Gln Arg Glu Asp
    130                 135                 140                 
Glu Glu Glu Glu Glu Gly Glu Asn Tyr Gln Lys Gly Glu Arg Gly Glu
145                 150                 155                 160 
Asp Ser Ser Glu Glu Lys His Leu Glu Glu Pro Gly Glu Thr Gln Asn
                165                 170                 175     
Ala Phe Leu Asn Glu Arg Lys Gln Ala Ser Ala Ile Lys Lys Glu Glu
            180                 185                 190         
Leu Val Ala Arg Ser Glu Thr His Ala Ala Gly His Ser Gln Glu Lys
        195                 200                 205             
Thr His Ser Arg Glu Lys Ser Ser Gln Glu Ser Gly Glu Glu Thr Gly
    210                 215                 220                 
Ser Gln Glu Asn His Pro Gln Glu Ser Lys Gly Gln Pro Arg Ser Gln
225                 230                 235                 240 
Glu Glu Ser Glu Glu Gly Glu Glu Asp Ala Thr Ser Glu Val Asp Lys
                245                 250                 255     
Arg Arg Thr Arg Pro Arg His His His Gly Arg Ser Arg Pro Asp Arg
            260                 265                 270         
Ser Ser Gln Gly Gly Ser Leu Pro Ser Glu Glu Lys Gly His Pro Gln
        275                 280                 285             
Glu
    


<210> 1495
<211> 747
<212> PRT
<213> Homo sapiens

<400> 1495
Met Phe Gly Gly Pro Gly Pro Gly Val Leu Gly Ala Gln Gly Met Ala
 1               5                  10                  15      
Gly Pro Leu Arg Gly Arg Val Glu Glu Leu Lys Leu Pro Trp Trp Arg
            20                  25                  30          
Glu Ser Ser Pro Leu Val Leu Arg His Ser Glu Ala Ala Arg Leu Ala
        35                  40                  45              
Ala Asp Ala Leu Leu Glu Arg Gly Glu Ala Ala Tyr Leu Arg Val Ile
    50                  55                  60                  
Ser Glu Glu Arg Glu Leu Pro Phe Leu Ser Ala Leu Asp Val Asp Tyr
65                  70                  75                  80  
Met Thr Ser His Val Arg Gly Gly Pro Glu Leu Ser Glu Ala Gln Gly
                85                  90                  95      
Gln Glu Ala Ser Gly Pro Asp Arg Leu Ser Leu Leu Ser Glu Val Thr
            100                 105                 110         
Ser Gly Thr Tyr Phe Pro Met Ala Ser Asp Ile Asp Pro Pro Asp Leu
        115                 120                 125             
Asp Leu Gly Trp Pro Glu Val Pro Gln Ala Thr Gly Phe Ser Pro Thr
    130                 135                 140                 
Gln Ala Val Val His Phe Gln Arg Asp Lys Ala Lys Asn Ile Lys Asp
145                 150                 155                 160 
Leu Leu Arg Phe Leu Phe Ser Gln Ala His Thr Val Val Ala Val Val
                165                 170                 175     
Met Asp Ile Phe Thr Asp Met Glu Leu Leu Cys Asp Leu Met Glu Ala
            180                 185                 190         
Ser Ser Arg Arg Gly Val Pro Val Tyr Leu Leu Leu Ala Gln Glu His
        195                 200                 205             
Leu Arg His Phe Leu Glu Met Cys Tyr Lys Met Asp Leu Asn Gly Glu
    210                 215                 220                 
His Leu Pro Asn Met Arg Val Arg Ser Thr Cys Gly Asp Thr Tyr Cys
225                 230                 235                 240 
Ser Lys Ala Gly Arg Arg Phe Thr Gly Gln Ala Leu Glu Lys Phe Val
                245                 250                 255     
Leu Ile Asp Cys Glu Gln Val Val Ala Gly Ser Tyr Ser Phe Thr Trp
            260                 265                 270         
Leu Cys Ser Gln Ala His Thr Ser Met Val Leu Gln Leu Arg Gly Arg
        275                 280                 285             
Ile Val Glu Asp Phe Asp Arg Glu Phe Arg Cys Leu Tyr Ala Glu Ser
    290                 295                 300                 
Gln Pro Val Glu Gly Phe Cys Gly Gly Glu Asp Pro Leu Ser Pro Arg
305                 310                 315                 320 
Ala Leu Arg Pro Pro Pro Val Ala Leu Ala Phe Arg Pro Asp Val Pro
                325                 330                 335     
Ser Pro Thr Ser Ser Leu Pro Ser Ser Thr Ser Leu Ser Ser Ile Lys
            340                 345                 350         
Gln Ser Pro Leu Met Gly Arg Ser Ser Tyr Leu Ala Leu Pro Gly Gly
        355                 360                 365             
Gly Asp Cys Ser Asp Thr Gly Val Val Ser Ser Ser Leu Gly Pro Ala
    370                 375                 380                 
Arg Arg Glu Ala Ser Gly Gln Pro Ser Leu His Arg Gln Leu Ser Asp
385                 390                 395                 400 
Pro Asn His Gly Ser Pro Pro Gly Leu Tyr Arg Ala Asn Leu Gly Lys
                405                 410                 415     
Leu Gly Ala Tyr Pro Trp Ser Gln Ser Ser Pro Ala Leu Asn His Asn
            420                 425                 430         
Ser Thr Ser Pro Leu Thr Leu Ala Val Gly Ser Pro Leu Leu Pro Arg
        435                 440                 445             
Ser Arg Pro Leu Leu Gln Phe His Arg Gly Ala Pro Ala Leu Ser Arg
    450                 455                 460                 
Phe Pro Glu Asn Gly Leu Pro Gly Ser Gln Glu Pro Ser Pro Leu Arg
465                 470                 475                 480 
Gly Arg Trp Val Pro Gly Thr Thr Leu Glu Thr Val Glu Glu Lys Glu
                485                 490                 495     
Lys Lys Ala Ser Pro Ser Gln Ser Arg Gly Gln Leu Asp Leu Leu Val
            500                 505                 510         
Pro Phe Pro Arg Ala Arg Glu Val Gly Asp Pro Asp Ser Gly Val Thr
        515                 520                 525             
Pro Asn Ser Gly Pro Leu Arg Pro Gly Glu Gln Ala Pro Glu Asp Arg
    530                 535                 540                 
Arg Leu Ser Pro Ser Gln Ala Asp Ser Gln Leu Asp Leu Leu Ser Arg
545                 550                 555                 560 
Ala Leu Gly Thr Gly Gly Ala Pro Glu Leu Gly Ser Leu Arg Pro Gly
                565                 570                 575     
Asp Arg Ala Leu Glu Asp Arg Arg Leu Ser Leu Asn Gln Ser Arg Gly
            580                 585                 590         
Gln Ser Asp Leu Leu Met Gln Tyr Pro Lys Ala Gln Gly Ser Arg Val
        595                 600                 605             
Pro Leu Glu Thr Asn Ser Ser Ala Arg Pro Ala Arg Arg Ala Pro Asp
    610                 615                 620                 
Glu Arg Arg Gln Thr Leu Gly His Ser Gln Leu Asp Leu Ile Thr Lys
625                 630                 635                 640 
Phe Gly Pro Phe Arg Gly Glu Gly Pro Gly Pro Asn Gly Leu Pro Ile
                645                 650                 655     
Ser Ser Pro Ala Arg Thr Ala Gly Ala Gly Ser Gly Asp Glu Lys Arg
            660                 665                 670         
Leu Thr Leu Gly His Ser Lys Leu Asp Leu Ile Thr Lys Tyr His Gln
        675                 680                 685             
Leu His Gly Ala Arg Gln Gly Thr Glu Pro Gly Gly Pro Lys Gly Gly
    690                 695                 700                 
His Leu Asn Gly Gly Asn Ser Asp Leu Val Arg Asp Glu Lys Arg Leu
705                 710                 715                 720 
Thr Leu Gly His Ser Lys Leu Asp Leu Ile Thr Lys Tyr Asn Lys Ser
                725                 730                 735     
Lys Phe Lys Gln Leu Arg Ser Arg Phe Glu Ser
            740                 745         


<210> 1496
<211> 254
<212> PRT
<213> Homo sapiens

<400> 1496
Met His Arg Leu Phe Thr Pro Gln Ser Gly Phe Glu Asn Gln Met Arg
 1               5                  10                  15      
Leu Cys Trp Arg Arg Pro Cys Gly Asn Glu Glu Arg Cys Ser Val Cys
            20                  25                  30          
Trp Ser Leu Phe Leu Pro Pro Gly Lys Gln Leu Cys Glu Glu Glu Arg
        35                  40                  45              
Arg Ala Met Gln Ala Ala Leu Asp Ser Val Val Cys His Thr Pro Leu
    50                  55                  60                  
Asn Asn Leu Gly Phe Ser Arg Lys Gly Ser Ala Leu Thr Phe Ser Val
65                  70                  75                  80  
Ala Phe Gln Ala Leu Arg Thr Gly Leu Phe Glu Leu Ser Gln His Met
                85                  90                  95      
Lys Leu Lys Leu Gln Phe Thr Ala Ser Val Ser His Pro Pro Pro Glu
            100                 105                 110         
Ala Arg Pro Leu Ser Arg Lys Ser Ser Pro Arg Ser Pro Ala Val Arg
        115                 120                 125             
Asp Leu Val Glu Arg His Gln Ala Ser Leu Gly Arg Ser Gln Ser Phe
    130                 135                 140                 
Ser His Gln Gln Pro Ser Arg Ser His Leu Met Arg Ser Gly Ser Val
145                 150                 155                 160 
Met Glu Arg Arg Ala Ser Arg Pro Leu Trp Pro Leu Leu Leu Ala Ala
                165                 170                 175     
Pro Ser Thr Cys Pro Arg Thr Arg Leu Cys Cys Leu Trp Thr Arg Leu
            180                 185                 190         
Pro Ser Ala Ser Ala Arg Ser Trp Trp Trp Asn Pro Ser Ser Ser Thr
        195                 200                 205             
Val Pro Ala Leu Phe Pro Leu Thr Leu Gln Arg Pro Asn Ala Pro Arg
    210                 215                 220                 
Gly Tyr Pro Cys Ser Arg Ala Val Pro Pro Leu Gly Cys Leu Pro Asp
225                 230                 235                 240 
Gly Gly Glu Glu Ala Trp Gln Ser Cys Leu Ser Cys Val Cys
                245                 250                 


<210> 1497
<211> 325
<212> PRT
<213> Homo sapiens

<400> 1497
Met Val Ser Pro Ala Thr Arg Lys Ser Leu Pro Lys Val Lys Ala Met
 1               5                  10                  15      
Asp Phe Ile Thr Ser Thr Ala Ile Leu Pro Leu Leu Phe Gly Cys Leu
            20                  25                  30          
Gly Val Phe Gly Leu Phe Arg Leu Leu Gln Trp Val Arg Gly Lys Ala
        35                  40                  45              
Tyr Leu Arg Asn Ala Val Val Val Ile Thr Gly Ala Thr Ser Gly Leu
    50                  55                  60                  
Gly Lys Glu Cys Ala Lys Val Phe Tyr Ala Ala Gly Ala Lys Leu Val
65                  70                  75                  80  
Leu Cys Gly Arg Asn Gly Gly Ala Leu Glu Glu Leu Ile Arg Glu Leu
                85                  90                  95      
Thr Ala Ser His Ala Thr Lys Val Gln Thr His Lys Pro Tyr Leu Val
            100                 105                 110         
Thr Phe Asp Leu Thr Asp Ser Gly Ala Ile Val Ala Ala Ala Ala Glu
        115                 120                 125             
Ile Leu Gln Cys Phe Gly Tyr Val Asp Ile Leu Val Asn Asn Ala Gly
    130                 135                 140                 
Ile Ser Tyr Arg Gly Thr Ile Met Asp Thr Thr Val Asp Val Asp Lys
145                 150                 155                 160 
Arg Val Met Glu Thr Asn Tyr Phe Gly Pro Val Ala Leu Thr Lys Ala
                165                 170                 175     
Leu Leu Pro Ser Met Ile Lys Arg Arg Gln Gly His Ile Val Ala Ile
            180                 185                 190         
Ser Ser Ile Gln Gly Lys Met Ser Ile Pro Phe Arg Ser Ala Tyr Ala
        195                 200                 205             
Ala Ser Lys His Ala Thr Gln Ala Phe Phe Asp Cys Leu Arg Ala Glu
    210                 215                 220                 
Met Glu Gln Tyr Glu Ile Glu Val Thr Val Ile Ser Pro Gly Tyr Ile
225                 230                 235                 240 
His Thr Asn Leu Ser Val Asn Ala Ile Thr Ala Asp Gly Ser Arg Tyr
                245                 250                 255     
Gly Val Met Asp Thr Thr Thr Ala Gln Gly Arg Ser Pro Val Glu Val
            260                 265                 270         
Ala Gln Asp Val Leu Ala Ala Val Gly Lys Lys Lys Lys Asp Val Ile
        275                 280                 285             
Leu Ala Asp Leu Leu Pro Ser Leu Ala Val Tyr Leu Arg Thr Leu Ala
    290                 295                 300                 
Pro Gly Leu Phe Phe Ser Leu Met Ala Ser Arg Ala Arg Lys Glu Arg
305                 310                 315                 320 
Lys Ser Lys Asn Ser
                325 


<210> 1498
<211> 378
<212> PRT
<213> Homo sapiens

<400> 1498
Met Val Leu Leu Trp Leu Thr Leu Leu Leu Ile Ala Leu Pro Cys Leu
 1               5                  10                  15      
Leu Gln Thr Lys Glu Asp Pro Asn Pro Pro Ile Thr Asn Leu Arg Met
            20                  25                  30          
Lys Ala Lys Ala Gln Gln Leu Thr Trp Asp Leu Asn Arg Asn Val Thr
        35                  40                  45              
Asp Ile Glu Cys Val Lys Asp Ala Asp Tyr Ser Met Pro Ala Val Asn
    50                  55                  60                  
Asn Ser Tyr Cys Gln Phe Gly Ala Ile Ser Leu Cys Glu Val Thr Asn
65                  70                  75                  80  
Tyr Thr Val Arg Val Ala Asn Pro Pro Phe Ser Thr Trp Ile Leu Phe
                85                  90                  95      
Pro Glu Asn Ser Gly Lys Pro Trp Ala Gly Ala Glu Asn Leu Thr Cys
            100                 105                 110         
Trp Ile His Asp Val Asp Phe Leu Ser Cys Ser Trp Ala Val Gly Pro
        115                 120                 125             
Gly Ala Pro Ala Asp Val Gln Tyr Asp Leu Tyr Leu Asn Val Ala Asn
    130                 135                 140                 
Arg Arg Gln Gln Tyr Glu Cys Leu His Tyr Lys Thr Asp Ala Gln Gly
145                 150                 155                 160 
Thr Arg Ile Gly Cys Arg Phe Asp Asp Ile Ser Arg Leu Ser Ser Gly
                165                 170                 175     
Ser Gln Ser Ser His Ile Leu Val Arg Gly Arg Ser Ala Ala Phe Gly
            180                 185                 190         
Ile Pro Cys Thr Asp Lys Phe Val Val Phe Ser Gln Ile Glu Ile Leu
        195                 200                 205             
Thr Pro Pro Asn Met Thr Ala Lys Cys Asn Lys Thr His Ser Phe Met
    210                 215                 220                 
His Trp Lys Met Arg Ser His Phe Asn Arg Lys Phe Arg Tyr Glu Leu
225                 230                 235                 240 
Gln Ile Gln Lys Arg Met Gln Pro Val Ile Thr Glu Gln Val Arg Asp
                245                 250                 255     
Arg Thr Ser Phe Gln Leu Leu Asn Pro Gly Thr Tyr Thr Val Gln Ile
            260                 265                 270         
Arg Ala Arg Glu Arg Val Tyr Glu Phe Leu Ser Ala Trp Ser Thr Pro
        275                 280                 285             
Gln Arg Phe Glu Cys Asp Gln Glu Glu Gly Ala Asn Thr Arg Ala Trp
    290                 295                 300                 
Arg Thr Ser Leu Leu Ile Ala Leu Gly Thr Leu Leu Ala Leu Val Cys
305                 310                 315                 320 
Val Phe Val Ile Cys Arg Arg Tyr Leu Val Met Gln Arg Leu Phe Pro
                325                 330                 335     
Arg Ile Pro His Met Lys Asp Pro Ile Gly Asp Ser Phe Gln Asn Asp
            340                 345                 350         
Lys Leu Val Val Trp Glu Ala Gly Lys Ala Gly Leu Glu Glu Cys Leu
        355                 360                 365             
Val Thr Glu Val Gln Val Val Gln Lys Thr
    370                 375             


<210> 1499
<211> 3312
<212> PRT
<213> Homo sapiens

<400> 1499
Met Met Ala Arg Arg Pro Pro Trp Arg Gly Leu Gly Glu Arg Ser Thr
 1               5                  10                  15      
Pro Ile Leu Leu Leu Leu Leu Leu Ser Leu Phe Pro Leu Ser Gln Glu
            20                  25                  30          
Glu Leu Gly Gly Gly Gly His Gln Gly Trp Asp Pro Gly Leu Ala Ala
        35                  40                  45              
Thr Thr Gly Pro Arg Ala His Ile Gly Gly Gly Ala Leu Ala Leu Cys
    50                  55                  60                  
Pro Glu Ser Ser Gly Val Arg Glu Asp Gly Gly Pro Gly Leu Gly Val
65                  70                  75                  80  
Arg Glu Pro Ile Phe Val Gly Leu Arg Gly Arg Arg Gln Ser Ala Arg
                85                  90                  95      
Asn Ser Arg Gly Pro Pro Glu Gln Pro Asn Glu Glu Leu Gly Ile Glu
            100                 105                 110         
His Gly Val Gln Pro Leu Gly Ser Arg Glu Arg Glu Thr Gly Gln Gly
        115                 120                 125             
Pro Gly Ser Val Leu Tyr Trp Arg Pro Glu Val Ser Ser Cys Gly Arg
    130                 135                 140                 
Thr Gly Pro Leu Gln Arg Gly Ser Leu Ser Pro Gly Ala Leu Ser Ser
145                 150                 155                 160 
Gly Val Pro Gly Ser Gly Asn Ser Ser Pro Leu Pro Ser Asp Phe Leu
                165                 170                 175     
Ile Arg His His Gly Pro Lys Pro Val Ser Ser Gln Arg Asn Ala Gly
            180                 185                 190         
Thr Gly Ser Arg Lys Arg Val Gly Thr Ala Arg Cys Cys Gly Glu Leu
        195                 200                 205             
Trp Ala Thr Gly Ser Lys Gly Gln Gly Glu Arg Ala Thr Thr Ser Gly
    210                 215                 220                 
Ala Glu Arg Thr Ala Pro Arg Arg Asn Cys Leu Pro Gly Ala Ser Gly
225                 230                 235                 240 
Ser Gly Pro Glu Leu Asp Ser Ala Pro Arg Thr Ala Arg Thr Ala Pro
                245                 250                 255     
Ala Ser Gly Ser Ala Pro Arg Glu Ser Arg Thr Ala Pro Glu Pro Ala
            260                 265                 270         
Pro Lys Arg Met Arg Ser Arg Gly Leu Phe Arg Cys Arg Phe Leu Pro
        275                 280                 285             
Gln Arg Pro Gly Pro Arg Pro Pro Gly Leu Pro Ala Arg Pro Glu Ala
    290                 295                 300                 
Arg Lys Val Thr Ser Ala Asn Arg Ala Arg Phe Arg Arg Ala Ala Asn
305                 310                 315                 320 
Arg His Pro Gln Phe Pro Gln Tyr Asn Tyr Gln Thr Leu Val Pro Glu
                325                 330                 335     
Asn Glu Ala Ala Gly Thr Ala Val Leu Arg Val Val Ala Gln Asp Pro
            340                 345                 350         
Asp Ala Gly Glu Ala Gly Arg Leu Val Tyr Ser Leu Ala Ala Leu Met
        355                 360                 365             
Asn Ser Arg Ser Leu Glu Leu Phe Ser Ile Asp Pro Gln Ser Gly Leu
    370                 375                 380                 
Ile Arg Thr Ala Ala Ala Leu Asp Arg Glu Ser Met Glu Arg His Tyr
385                 390                 395                 400 
Leu Arg Val Thr Ala Gln Asp His Gly Ser Pro Arg Leu Ser Ala Thr
                405                 410                 415     
Thr Met Val Ala Val Thr Val Ala Asp Arg Asn Asp His Ser Pro Val
            420                 425                 430         
Phe Glu Gln Ala Gln Tyr Arg Glu Thr Leu Arg Glu Asn Val Glu Glu
        435                 440                 445             
Gly Tyr Pro Ile Leu Gln Leu Arg Ala Thr Asp Gly Asp Ala Pro Pro
    450                 455                 460                 
Asn Ala Asn Leu Arg Tyr Arg Phe Val Gly Pro Pro Ala Ala Arg Ala
465                 470                 475                 480 
Ala Ala Ala Ala Ala Phe Glu Ile Asp Pro Arg Ser Gly Leu Ile Ser
                485                 490                 495     
Thr Ser Gly Arg Val Asp Arg Glu His Met Glu Ser Tyr Glu Leu Val
            500                 505                 510         
Val Glu Ala Ser Asp Gln Gly Gln Glu Pro Gly Pro Arg Ser Ala Thr
        515                 520                 525             
Val Arg Val His Ile Thr Val Leu Asp Glu Asn Asp Asn Ala Pro Gln
    530                 535                 540                 
Phe Ser Glu Lys Arg Tyr Val Ala Gln Val Arg Glu Asp Val Arg Pro
545                 550                 555                 560 
His Thr Val Val Leu Arg Val Thr Ala Thr Asp Arg Asp Lys Asp Ala
                565                 570                 575     
Asn Gly Leu Val His Tyr Asn Ile Ile Ser Gly Asn Ser Arg Gly His
            580                 585                 590         
Phe Ala Ile Asp Ser Leu Thr Gly Glu Ile Gln Val Val Ala Pro Leu
        595                 600                 605             
Asp Phe Glu Ala Glu Arg Glu Tyr Ala Leu Arg Ile Arg Ala Gln Asp
    610                 615                 620                 
Ala Gly Arg Pro Pro Leu Ser Asn Asn Thr Gly Leu Ala Ser Ile Gln
625                 630                 635                 640 
Val Val Asp Ile Asn Asp His Ile Pro Ile Phe Val Ser Thr Pro Phe
                645                 650                 655     
Gln Val Ser Val Leu Glu Asn Ala Pro Leu Gly His Ser Val Ile His
            660                 665                 670         
Ile Gln Ala Val Asp Ala Asp His Gly Glu Asn Ala Arg Leu Glu Tyr
        675                 680                 685             
Ser Leu Thr Gly Val Ala Pro Asp Thr Pro Phe Val Ile Asn Ser Ala
    690                 695                 700                 
Thr Gly Trp Val Ser Val Ser Gly Pro Leu Asp Arg Glu Ser Val Glu
705                 710                 715                 720 
His Tyr Phe Phe Gly Val Glu Ala Arg Asp His Gly Ser Pro Pro Leu
                725                 730                 735     
Ser Ala Ser Ala Ser Val Thr Val Thr Val Leu Asp Val Asn Asp Asn
            740                 745                 750         
Arg Pro Glu Phe Thr Met Lys Glu Tyr His Leu Arg Leu Asn Glu Asp
        755                 760                 765             
Ala Ala Val Gly Thr Ser Val Val Ser Val Thr Ala Val Asp Arg Asp
    770                 775                 780                 
Ala Asn Ser Ala Ile Ser Tyr Gln Ile Thr Gly Gly Asn Thr Arg Asn
785                 790                 795                 800 
Arg Phe Ala Ile Ser Thr Gln Gly Gly Val Gly Leu Val Thr Leu Ala
                805                 810                 815     
Leu Pro Leu Asp Tyr Lys Gln Glu Arg Tyr Phe Lys Leu Val Leu Thr
            820                 825                 830         
Ala Ser Asp Arg Ala Leu His Asp His Cys Tyr Val His Ile Asn Ile
        835                 840                 845             
Thr Asp Ala Asn Thr His Arg Pro Val Phe Gln Ser Ala His Tyr Ser
    850                 855                 860                 
Val Ser Val Asn Glu Asp Arg Pro Met Gly Ser Thr Ile Val Val Ile
865                 870                 875                 880 
Ser Ala Ser Asp Asp Asp Val Gly Glu Asn Ala Arg Ile Thr Tyr Leu
                885                 890                 895     
Leu Glu Asp Asn Leu Pro Gln Phe Arg Ile Asp Ala Asp Ser Gly Ala
            900                 905                 910         
Ile Thr Leu Gln Ala Pro Leu Asp Tyr Glu Asp Gln Val Thr Tyr Thr
        915                 920                 925             
Leu Ala Ile Thr Ala Arg Asp Asn Gly Ile Pro Gln Lys Ala Asp Thr
    930                 935                 940                 
Thr Tyr Val Glu Val Met Val Asn Asp Val Asn Asp Asn Ala Pro Gln
945                 950                 955                 960 
Phe Val Ala Ser His Tyr Thr Gly Leu Val Ser Glu Asp Ala Pro Pro
                965                 970                 975     
Phe Thr Ser Val Leu Gln Ile Ser Ala Thr Asp Arg Asp Ala His Ala
            980                 985                 990         
Asn Gly Arg Val Gln Tyr Thr Phe Gln Asn Gly Glu Asp Gly Asp Gly
        995                 1000                1005            
Asp Phe Thr Ile Glu Pro Thr Ser Gly Ile Val Arg Thr Val Arg Arg
    1010                1015                1020                
Leu Asp Arg Glu Ala Val Ser Val Tyr Glu Leu Thr Ala Tyr Ala Val
1025                1030                1035                1040
Asp Arg Gly Val Pro Pro Leu Arg Thr Pro Val Ser Ile Gln Val Met
                1045                1050                1055    
Val Gln Asp Val Asn Asp Asn Ala Pro Val Phe Pro Ala Glu Glu Phe
            1060                1065                1070        
Glu Val Arg Val Lys Glu Asn Ser Ile Val Gly Ser Val Val Ala Gln
        1075                1080                1085            
Ile Thr Ala Val Asp Pro Asp Glu Gly Pro Asn Ala His Ile Met Tyr
    1090                1095                1100                
Gln Ile Val Glu Gly Asn Ile Pro Glu Leu Phe Gln Met Asp Ile Phe
1105                1110                1115                1120
Ser Gly Glu Leu Thr Ala Leu Ile Asp Leu Asp Tyr Glu Ala Arg Gln
                1125                1130                1135    
Glu Tyr Val Ile Val Val Gln Ala Thr Ser Ala Pro Leu Val Ser Arg
            1140                1145                1150        
Ala Thr Val His Val Arg Leu Val Asp Gln Asn Asp Asn Ser Pro Val
        1155                1160                1165            
Leu Asn Asn Phe Gln Ile Leu Phe Asn Asn Tyr Val Ser Asn Arg Ser
    1170                1175                1180                
Asp Thr Phe Pro Ser Gly Ile Ile Gly Arg Ile Pro Ala Tyr Asp Pro
1185                1190                1195                1200
Asp Val Ser Asp His Leu Phe Tyr Ser Phe Glu Arg Gly Asn Glu Leu
                1205                1210                1215    
Gln Leu Leu Val Val Asn Gln Thr Ser Gly Glu Leu Arg Leu Ser Arg
            1220                1225                1230        
Lys Leu Asp Asn Asn Arg Pro Leu Val Ala Ser Met Leu Val Thr Val
        1235                1240                1245            
Thr Asp Gly Leu His Ser Val Thr Ala Gln Cys Val Leu Arg Val Val
    1250                1255                1260                
Ile Ile Thr Glu Glu Leu Leu Ala Asn Ser Leu Thr Val Arg Leu Glu
1265                1270                1275                1280
Asn Met Trp Gln Glu Arg Phe Leu Ser Pro Leu Leu Gly Arg Phe Leu
                1285                1290                1295    
Glu Gly Val Ala Ala Val Leu Ala Thr Pro Ala Glu Asp Val Phe Ile
            1300                1305                1310        
Phe Asn Ile Gln Asn Asp Thr Asp Val Gly Gly Thr Val Leu Asn Val
        1315                1320                1325            
Ser Phe Ser Ala Leu Ala Pro Arg Gly Ala Gly Ala Gly Ala Ala Gly
    1330                1335                1340                
Pro Trp Phe Ser Ser Glu Glu Leu Gln Glu Gln Leu Tyr Val Arg Arg
1345                1350                1355                1360
Ala Ala Leu Ala Ala Arg Ser Leu Leu Asp Val Leu Pro Phe Asp Asp
                1365                1370                1375    
Asn Val Cys Leu Arg Glu Pro Cys Glu Asn Tyr Met Lys Cys Val Ser
            1380                1385                1390        
Val Leu Arg Phe Asp Ser Ser Ala Pro Phe Leu Ala Ser Ala Ser Thr
        1395                1400                1405            
Leu Phe Arg Pro Ile Gln Pro Ile Ala Gly Leu Arg Cys Arg Cys Pro
    1410                1415                1420                
Pro Gly Phe Thr Gly Asp Phe Cys Glu Thr Glu Leu Asp Leu Cys Tyr
1425                1430                1435                1440
Ser Asn Pro Cys Arg Asn Gly Gly Ala Cys Ala Arg Arg Glu Gly Gly
                1445                1450                1455    
Tyr Thr Cys Val Cys Arg Pro Arg Phe Thr Gly Glu Asp Cys Glu Leu
            1460                1465                1470        
Asp Thr Glu Ala Gly Arg Cys Val Pro Gly Val Cys Arg Asn Gly Gly
        1475                1480                1485            
Thr Cys Thr Asp Ala Pro Asn Gly Gly Phe Arg Cys Gln Cys Pro Ala
    1490                1495                1500                
Gly Gly Ala Phe Glu Gly Pro Arg Cys Glu Val Ala Ala Arg Ser Phe
1505                1510                1515                1520
Pro Pro Ser Ser Phe Val Met Phe Arg Gly Leu Arg Gln Arg Phe His
                1525                1530                1535    
Leu Thr Leu Ser Leu Ser Phe Ala Thr Val Gln Gln Ser Gly Leu Leu
            1540                1545                1550        
Phe Tyr Asn Gly Arg Leu Asn Glu Lys His Asp Phe Leu Ala Leu Glu
        1555                1560                1565            
Leu Val Ala Gly Gln Val Arg Leu Thr Tyr Ser Thr Gly Glu Ser Asn
    1570                1575                1580                
Thr Val Val Ser Pro Thr Val Pro Gly Gly Leu Ser Asp Gly Gln Trp
1585                1590                1595                1600
His Thr Val His Leu Arg Tyr Tyr Asn Lys Pro Arg Thr Asp Ala Leu
                1605                1610                1615    
Gly Gly Ala Gln Gly Pro Ser Lys Asp Lys Val Ala Val Leu Ser Val
            1620                1625                1630        
Asp Asp Cys Asp Val Ala Val Ala Leu Gln Phe Gly Ala Glu Ile Gly
        1635                1640                1645            
Asn Tyr Ser Cys Ala Ala Ala Gly Val Gln Thr Ser Ser Lys Lys Ser
    1650                1655                1660                
Leu Asp Leu Thr Gly Pro Leu Leu Leu Gly Gly Val Pro Asn Leu Pro
1665                1670                1675                1680
Glu Asn Phe Pro Val Ser His Lys Asp Phe Ile Gly Cys Met Arg Asp
                1685                1690                1695    
Leu His Ile Asp Gly Arg Arg Val Asp Met Ala Ala Phe Val Ala Asn
            1700                1705                1710        
Asn Gly Thr Met Ala Gly Cys Gln Ala Lys Leu His Phe Cys Asp Ser
        1715                1720                1725            
Gly Pro Cys Lys Asn Ser Gly Phe Cys Ser Glu Arg Trp Gly Ser Phe
    1730                1735                1740                
Ser Cys Asp Cys Pro Val Gly Phe Gly Gly Lys Asp Cys Gln Leu Thr
1745                1750                1755                1760
Met Ala His Pro His His Phe Arg Gly Asn Gly Thr Leu Ser Trp Asn
                1765                1770                1775    
Phe Gly Ser Asp Met Ala Val Ser Val Pro Trp Tyr Leu Gly Leu Ala
            1780                1785                1790        
Phe Arg Thr Arg Ala Thr Gln Gly Val Leu Met Gln Val Gln Ala Gly
        1795                1800                1805            
Pro His Ser Thr Leu Leu Cys Gln Leu Asp Arg Gly Leu Leu Ser Val
    1810                1815                1820                
Thr Val Thr Arg Gly Ser Gly Arg Ala Ser His Leu Leu Leu Asp Gln
1825                1830                1835                1840
Val Thr Val Ser Asp Gly Arg Trp His Asp Leu Arg Leu Glu Leu Gln
                1845                1850                1855    
Glu Glu Pro Gly Gly Arg Arg Gly His His Val Leu Met Val Ser Leu
            1860                1865                1870        
Asp Phe Ser Leu Phe Gln Asp Thr Met Ala Val Gly Ser Glu Leu Gln
        1875                1880                1885            
Gly Leu Lys Val Lys Gln Leu His Val Gly Gly Leu Pro Pro Gly Ser
    1890                1895                1900                
Ala Glu Glu Ala Pro Gln Gly Leu Val Gly Cys Ile Gln Gly Val Trp
1905                1910                1915                1920
Leu Gly Ser Thr Pro Ser Gly Ser Pro Ala Leu Leu Pro Pro Ser His
                1925                1930                1935    
Arg Val Asn Ala Glu Pro Gly Cys Val Val Thr Asn Ala Cys Ala Ser
            1940                1945                1950        
Gly Pro Cys Pro Pro His Ala Asp Cys Arg Asp Leu Trp Gln Thr Phe
        1955                1960                1965            
Ser Cys Thr Cys Gln Pro Gly Tyr Tyr Gly Pro Gly Cys Val Asp Ala
    1970                1975                1980                
Cys Leu Leu Asn Pro Cys Gln Asn Gln Gly Ser Cys Arg His Leu Pro
1985                1990                1995                2000
Gly Ala Pro His Gly Tyr Thr Cys Asp Cys Val Gly Gly Tyr Phe Gly
                2005                2010                2015    
His His Cys Glu His Arg Met Asp Gln Gln Cys Pro Arg Gly Trp Trp
            2020                2025                2030        
Gly Ser Pro Thr Cys Gly Pro Cys Asn Cys Asp Val His Lys Gly Phe
        2035                2040                2045            
Asp Pro Asn Cys Asn Lys Thr Asn Gly Gln Cys His Cys Lys Glu Phe
    2050                2055                2060                
His Tyr Arg Pro Arg Gly Ser Asp Ser Cys Leu Pro Cys Asp Cys Tyr
2065                2070                2075                2080
Pro Val Gly Ser Thr Ser Arg Ser Cys Ala Pro His Ser Gly Gln Cys
                2085                2090                2095    
Pro Cys Arg Pro Gly Ala Leu Gly Arg Gln Cys Asn Ser Cys Asp Ser
            2100                2105                2110        
Pro Phe Ala Glu Val Thr Ala Ser Gly Cys Arg Val Leu Tyr Asp Ala
        2115                2120                2125            
Cys Pro Lys Ser Leu Arg Ser Gly Val Trp Trp Pro Gln Thr Lys Phe
    2130                2135                2140                
Gly Val Leu Ala Thr Val Pro Cys Pro Arg Gly Ala Leu Gly Ala Ala
2145                2150                2155                2160
Val Arg Leu Cys Asp Glu Ala Gln Gly Trp Leu Glu Pro Asp Leu Phe
                2165                2170                2175    
Asn Cys Thr Ser Pro Ala Phe Arg Glu Leu Ser Leu Leu Leu Asp Gly
            2180                2185                2190        
Leu Glu Leu Asn Lys Thr Ala Leu Asp Thr Met Glu Ala Lys Lys Leu
        2195                2200                2205            
Ala Gln Arg Leu Arg Glu Val Thr Gly His Thr Asp His Tyr Phe Ser
    2210                2215                2220                
Gln Asp Val Arg Val Thr Ala Arg Leu Leu Ala His Leu Leu Ala Phe
2225                2230                2235                2240
Glu Ser His Gln Gln Gly Phe Gly Leu Thr Ala Thr Gln Asp Ala His
                2245                2250                2255    
Phe Asn Glu Asn Leu Leu Trp Ala Gly Ser Ala Leu Leu Ala Pro Glu
            2260                2265                2270        
Thr Gly Asp Leu Trp Ala Ala Leu Gly Gln Arg Ala Pro Gly Gly Ser
        2275                2280                2285            
Pro Gly Ser Ala Gly Leu Val Arg His Leu Glu Glu Tyr Ala Ala Thr
    2290                2295                2300                
Leu Ala Arg Asn Met Glu Leu Thr Tyr Leu Asn Pro Met Gly Leu Val
2305                2310                2315                2320
Thr Pro Asn Ile Met Leu Ser Ile Asp Arg Met Glu His Pro Ser Ser
                2325                2330                2335    
Pro Arg Gly Ala Arg Arg Tyr Pro Arg Tyr His Ser Asn Leu Phe Arg
            2340                2345                2350        
Gly Gln Asp Ala Trp Asp Pro His Thr His Val Leu Leu Pro Ser Gln
        2355                2360                2365            
Ser Pro Arg Pro Ser Pro Ser Glu Val Leu Pro Thr Ser Ser Ser Ile
    2370                2375                2380                
Glu Asn Ser Thr Thr Ser Ser Val Val Pro Pro Pro Ala Pro Pro Glu
2385                2390                2395                2400
Pro Glu Pro Gly Ile Ser Ile Ile Ile Leu Leu Val Tyr Arg Thr Leu
                2405                2410                2415    
Gly Gly Leu Leu Pro Ala Gln Phe Gln Ala Glu Arg Arg Gly Ala Arg
            2420                2425                2430        
Leu Pro Gln Asn Pro Val Met Asn Ser Pro Val Val Ser Val Ala Val
        2435                2440                2445            
Phe His Gly Arg Asn Phe Leu Arg Gly Ile Leu Glu Ser Pro Ile Ser
    2450                2455                2460                
Leu Glu Phe Arg Leu Leu Gln Thr Ala Asn Arg Ser Lys Ala Ile Cys
2465                2470                2475                2480
Val Gln Trp Asp Pro Pro Gly Leu Ala Glu Gln His Gly Val Trp Thr
                2485                2490                2495    
Ala Arg Asp Cys Glu Leu Val His Arg Asn Gly Ser His Ala Arg Cys
            2500                2505                2510        
Arg Cys Ser Arg Thr Gly Thr Phe Gly Val Leu Met Asp Ala Ser Pro
        2515                2520                2525            
Arg Glu Arg Leu Glu Gly Asp Leu Glu Leu Leu Ala Val Phe Thr His
    2530                2535                2540                
Val Val Val Ala Val Ser Val Ala Ala Leu Val Leu Thr Ala Ala Ile
2545                2550                2555                2560
Leu Leu Ser Leu Arg Ser Leu Lys Ser Asn Val Arg Gly Ile His Ala
                2565                2570                2575    
Asn Val Ala Ala Ala Leu Gly Val Ala Glu Leu Leu Phe Leu Leu Gly
            2580                2585                2590        
Ile His Arg Thr His Asn Gln Leu Val Cys Thr Ala Val Ala Ile Leu
        2595                2600                2605            
Leu His Tyr Phe Phe Leu Ser Thr Phe Ala Trp Leu Phe Val Gln Gly
    2610                2615                2620                
Leu His Leu Tyr Arg Met Gln Val Glu Pro Arg Asn Val Asp Arg Gly
2625                2630                2635                2640
Ala Met Arg Phe Tyr His Ala Leu Gly Trp Gly Val Pro Ala Val Leu
                2645                2650                2655    
Leu Gly Leu Ala Val Gly Leu Asp Pro Glu Gly Tyr Gly Asn Pro Asp
            2660                2665                2670        
Phe Cys Trp Ile Ser Val His Glu Pro Leu Ile Trp Ser Phe Ala Gly
        2675                2680                2685            
Pro Val Val Leu Val Ile Val Met Asn Gly Thr Met Phe Leu Leu Ala
    2690                2695                2700                
Ala Arg Thr Ser Cys Ser Thr Gly Gln Arg Glu Ala Lys Lys Thr Ser
2705                2710                2715                2720
Ala Leu Thr Leu Arg Ser Ser Phe Leu Leu Leu Leu Leu Val Ser Ala
                2725                2730                2735    
Ser Trp Leu Phe Gly Leu Leu Ala Val Asn His Ser Ile Leu Ala Phe
            2740                2745                2750        
His Tyr Leu His Ala Gly Leu Cys Gly Leu Gln Gly Leu Ala Val Leu
        2755                2760                2765            
Leu Leu Phe Cys Val Leu Asn Ala Asp Ala Arg Ala Ala Trp Met Pro
    2770                2775                2780                
Ala Cys Leu Gly Arg Lys Ala Ala Pro Glu Glu Ala Arg Pro Ala Pro
2785                2790                2795                2800
Gly Leu Gly Pro Gly Ala Tyr Asn Asn Thr Ala Leu Phe Glu Glu Ser
                2805                2810                2815    
Gly Leu Ile Arg Ile Thr Leu Gly Ala Ser Thr Val Ser Ser Val Ser
            2820                2825                2830        
Ser Ala Arg Ser Gly Arg Thr Gln Asp Gln Asp Ser Gln Arg Gly Arg
        2835                2840                2845            
Ser Tyr Leu Arg Asp Asn Val Leu Val Arg His Gly Ser Ala Ala Asp
    2850                2855                2860                
His Thr Asp His Ser Leu Gln Ala His Ala Gly Pro Thr Asp Leu Asp
2865                2870                2875                2880
Val Ala Met Phe His Arg Asp Ala Gly Ala Asp Ser Asp Ser Asp Ser
                2885                2890                2895    
Asp Leu Ser Leu Glu Glu Glu Arg Ser Leu Ser Ile Pro Ser Ser Glu
            2900                2905                2910        
Ser Glu Asp Asn Gly Arg Thr Arg Gly Arg Phe Gln Arg Pro Leu Cys
        2915                2920                2925            
Arg Ala Ala Gln Ser Glu Arg Leu Leu Thr His Pro Lys Asp Val Asp
    2930                2935                2940                
Gly Asn Asp Leu Leu Ser Tyr Trp Pro Ala Leu Gly Glu Cys Glu Ala
2945                2950                2955                2960
Ala Pro Cys Ala Leu Gln Thr Trp Gly Ser Glu Arg Arg Leu Gly Leu
                2965                2970                2975    
Asp Thr Ser Lys Asp Ala Ala Asn Asn Asn Gln Pro Asp Pro Ala Leu
            2980                2985                2990        
Thr Ser Gly Asp Glu Thr Ser Leu Gly Arg Ala Gln Arg Gln Arg Lys
        2995                3000                3005            
Gly Ile Leu Lys Asn Arg Leu Gln Tyr Pro Leu Val Pro Gln Thr Arg
    3010                3015                3020                
Gly Ala Pro Glu Leu Ser Trp Cys Arg Ala Ala Thr Leu Gly His Arg
3025                3030                3035                3040
Ala Val Pro Ala Ala Ser Tyr Gly Arg Ile Tyr Ala Gly Gly Gly Thr
                3045                3050                3055    
Gly Ser Leu Ser Gln Pro Ala Ser Arg Tyr Ser Ser Arg Glu Gln Leu
            3060                3065                3070        
Asp Leu Leu Leu Arg Arg Gln Leu Ser Arg Glu Arg Leu Glu Glu Ala
        3075                3080                3085            
Pro Ala Pro Val Leu Arg Pro Leu Ser Arg Pro Gly Ser Gln Glu Cys
    3090                3095                3100                
Met Asp Ala Ala Pro Gly Arg Leu Glu Pro Lys Asp Arg Gly Ser Thr
3105                3110                3115                3120
Leu Pro Arg Arg Gln Pro Pro Arg Asp Tyr Pro Gly Ala Met Ala Gly
                3125                3130                3135    
Arg Phe Gly Ser Arg Asp Ala Leu Asp Leu Gly Ala Pro Arg Glu Trp
            3140                3145                3150        
Leu Ser Thr Leu Pro Pro Pro Arg Arg Thr Arg Asp Leu Asp Pro Gln
        3155                3160                3165            
Pro Pro Pro Leu Pro Leu Ser Pro Gln Arg Gln Leu Ser Arg Asp Pro
    3170                3175                3180                
Leu Leu Pro Ser Arg Pro Leu Asp Ser Leu Ser Arg Ser Ser Asn Ser
3185                3190                3195                3200
Arg Glu Gln Leu Asp Gln Val Pro Ser Arg His Pro Ser Arg Glu Ala
                3205                3210                3215    
Leu Gly Pro Leu Pro Gln Leu Leu Arg Ala Arg Glu Asp Ser Val Ser
            3220                3225                3230        
Gly Pro Ser His Gly Pro Ser Thr Glu Gln Leu Asp Ile Leu Ser Ser
        3235                3240                3245            
Ile Leu Ala Ser Phe Asn Ser Ser Ala Leu Ser Ser Val Gln Ser Ser
    3250                3255                3260                
Ser Thr Pro Leu Gly Pro His Thr Thr Ala Thr Pro Ser Ala Thr Ala
3265                3270                3275                3280
Ser Val Leu Gly Pro Ser Thr Pro Arg Ser Ala Thr Ser His Ser Ile
                3285                3290                3295    
Ser Glu Leu Ser Pro Asp Ser Glu Val Pro Arg Ser Glu Gly His Ser
            3300                3305                3310        


<210> 1500
<211> 409
<212> PRT
<213> Homo sapiens

<400> 1500
Ala Asp Ser Ser Gly Arg Gly Ala Gly Lys Pro Ala Thr Gly Pro Thr
 1               5                  10                  15      
Asn Ser Ser Ser Ala Lys Lys Lys Asp Lys Arg Val Gln Gly Gly Arg
            20                  25                  30          
Val Ile Glu Ser Pro Tyr Leu Gln Tyr Glu Lys Lys Thr Thr Gln Lys
        35                  40                  45              
Ala Pro Ala Gly Asp Gly Ser Gln Thr Arg Gly Lys Met Ser Glu Gly
    50                  55                  60                  
Gly Arg Lys Ser Ser Leu Leu Gln Lys Ser Lys Ala Asp Ser Ser Gly
65                  70                  75                  80  
Val Arg Lys Gly Asp Leu Gln Ser Thr Leu Leu Glu Gly His Gly Thr
                85                  90                  95      
Ala Pro Pro Asp Leu Asp Leu Ser Ala Ile Asn Asp Lys Ser Ile Val
            100                 105                 110         
Lys Lys Thr Pro Gln Leu Ala Lys Thr Ile Ser Lys Lys Pro Glu Ser
        115                 120                 125             
Thr Ser Phe Ser Ala Pro Arg Lys Lys Ser Pro Asp Leu Ser Glu Ala
    130                 135                 140                 
Met Glu Met Met Glu Ser Gln Thr Leu Leu Leu Thr Leu Leu Ser Val
145                 150                 155                 160 
Lys Met Glu Asn Asn Leu Ala Glu Phe Glu Arg Arg Ala Glu Lys Asn
                165                 170                 175     
Leu Leu Ile Met Cys Lys Glu Lys Glu Lys Leu Gln Lys Lys Ala His
            180                 185                 190         
Glu Leu Lys Arg Arg Leu Leu Leu Ser Gln Arg Lys Arg Glu Leu Ala
        195                 200                 205             
Asp Val Leu Asp Ala Gln Ile Glu Met Leu Ser Pro Phe Glu Ala Val
    210                 215                 220                 
Ala Thr Arg Phe Lys Glu Gln Tyr Arg Thr Phe Ala Thr Ala Leu Asp
225                 230                 235                 240 
Thr Thr Arg His Glu Leu Pro Val Arg Ser Ile His Leu Glu Gly Asp
                245                 250                 255     
Gly Gln Gln Leu Leu Asp Ala Leu Gln His Glu Leu Val Thr Thr Gln
            260                 265                 270         
Arg Leu Leu Gly Glu Leu Asp Val Gly Asp Ser Glu Glu Asn Val Gln
        275                 280                 285             
Val Leu Asp Leu Leu Ser Glu Leu Lys Asp Val Thr Ala Lys Lys Asp
    290                 295                 300                 
Leu Glu Leu Arg Arg Ser Phe Ala Gln Val Leu Glu Leu Ser Ala Glu
305                 310                 315                 320 
Ala Ser Lys Glu Ala Ala Leu Ala Asn Gln Glu Val Trp Glu Glu Thr
                325                 330                 335     
Gln Gly Met Ala Pro Pro Ser Arg Trp Tyr Phe Asn Gln Asp Ser Ala
            340                 345                 350         
Cys Arg Glu Ser Gly Gly Ala Pro Lys Asn Thr Pro Leu Ser Glu Asp
        355                 360                 365             
Asp Asn Pro Gly Ala Ser Ser Ala Pro Ala Gln Ala Thr Phe Ile Ser
    370                 375                 380                 
Pro Ser Glu Asp Phe Ser Ser Ser Ser Gln Ala Glu Val Pro Pro Ser
385                 390                 395                 400 
Leu Ser Arg Ser Gly Arg Asp Leu Ser
                405                 


<210> 1501
<211> 334
<212> PRT
<213> Homo sapiens

<400> 1501
His Glu Ala Pro Cys Asp His Met Ala Tyr Ala Val Asn Cys Gln Val
 1               5                  10                  15      
Ile Thr Trp Gln Arg Ile Ile Ser His Phe Asp Ile Phe Ala Phe Gly
            20                  25                  30          
His Phe Trp Gly Trp Ala Met Lys Ala Leu Leu Ile Arg Ser Tyr Gly
        35                  40                  45              
Leu Cys Trp Thr Ile Ser Ile Thr Trp Glu Leu Thr Glu Leu Phe Phe
    50                  55                  60                  
Met His Leu Leu Pro Asn Phe Ala Glu Cys Trp Trp Asp Gln Val Ile
65                  70                  75                  80  
Leu Asp Ile Leu Leu Cys Asn Gly Gly Gly Ile Trp Leu Gly Met Val
                85                  90                  95      
Val Cys Arg Phe Leu Glu Met Arg Thr Tyr His Trp Ala Ser Phe Lys
            100                 105                 110         
Asp Ile His Thr Thr Thr Gly Lys Ile Lys Arg Ala Val Leu Gln Phe
        115                 120                 125             
Thr Pro Ala Ser Trp Thr Tyr Val Arg Trp Phe Asp Pro Lys Ser Ser
    130                 135                 140                 
Phe Gln Arg Val Ala Gly Val Tyr Leu Phe Met Ile Ile Trp Gln Leu
145                 150                 155                 160 
Thr Glu Leu Asn Thr Phe Phe Leu Lys His Ile Phe Val Phe Gln Ala
                165                 170                 175     
Ser His Pro Leu Ser Trp Gly Arg Ile Leu Phe Ile Gly Gly Ile Thr
            180                 185                 190         
Ala Pro Thr Val Arg Gln Tyr Tyr Ala Tyr Leu Thr Asp Thr Gln Cys
        195                 200                 205             
Lys Arg Val Gly Thr Gln Cys Trp Val Phe Gly Val Ile Gly Phe Leu
    210                 215                 220                 
Glu Ala Ile Val Cys Ile Lys Phe Gly Gln Asp Leu Phe Ser Lys Thr
225                 230                 235                 240 
Gln Ile Leu Tyr Val Val Leu Trp Leu Leu Cys Val Ala Phe Thr Thr
                245                 250                 255     
Phe Leu Cys Leu Tyr Gly Met Ile Trp Tyr Ala Glu His Tyr Gly His
            260                 265                 270         
Arg Glu Lys Thr Tyr Ser Glu Cys Glu Asp Gly Thr Tyr Ser Pro Glu
        275                 280                 285             
Ile Ser Trp His His Arg Lys Gly Thr Lys Gly Ser Glu Asp Ser Pro
    290                 295                 300                 
Pro Lys His Ala Gly Asn Asn Glu Ser His Ser Ser Arg Arg Arg Asn
305                 310                 315                 320 
Arg His Ser Lys Ser Lys Val Thr Asn Gly Val Gly Lys Lys
                325                 330                 


<210> 1502
<211> 900
<212> PRT
<213> Homo sapiens

<400> 1502
Ser Arg Gly Leu Ser Ser Leu Phe Thr Val Val Pro Cys Leu Ser Cys
 1               5                  10                  15      
His Thr Ala Ala Pro Gly Met Ser Ala Ser Thr Ser Gly Ser Gly Pro
            20                  25                  30          
Glu Pro Lys Pro Gln Pro Gln Pro Val Pro Glu Pro Glu Arg Gly Pro
        35                  40                  45              
Leu Ser Glu Gln Val Ser Glu Ala Val Ser Glu Ala Val Pro Arg Ser
    50                  55                  60                  
Glu Pro Val Ser Glu Thr Thr Ser Glu Pro Glu Pro Gly Ala Gly Gln
65                  70                  75                  80  
Pro Ser Glu Leu Leu Gln Gly Ser Arg Pro Gly Ser Glu Ser Ser Ser
                85                  90                  95      
Gly Val Gly Ala Gly Pro Phe Thr Lys Ala Ala Ser Glu Pro Leu Ser
            100                 105                 110         
Arg Ala Val Gly Ser Ala Thr Phe Leu Arg Pro Glu Ser Gly Ser Leu
        115                 120                 125             
Pro Ala Leu Lys Pro Leu Pro Leu Leu Arg Pro Gly Gln Ala Lys Thr
    130                 135                 140                 
Pro Leu Gly Val Pro Met Ser Gly Thr Gly Thr Thr Ser Ser Ala Pro
145                 150                 155                 160 
Leu Ala Leu Leu Pro Leu Asp Ser Phe Glu Gly Trp Leu Leu Lys Trp
                165                 170                 175     
Thr Asn Tyr Leu Lys Gly Tyr Gln Arg Arg Trp Phe Val Leu Gly Asn
            180                 185                 190         
Gly Leu Leu Ser Tyr Tyr Arg Asn Gln Gly Glu Met Ala His Thr Cys
        195                 200                 205             
Arg Gly Thr Ile Asn Leu Ser Thr Ala His Ile Asp Thr Glu Asp Ser
    210                 215                 220                 
Cys Gly Ile Leu Leu Thr Ser Gly Ala Arg Ser Tyr His Leu Lys Ala
225                 230                 235                 240 
Ser Ser Glu Val Asp Arg Gln Gln Trp Ile Thr Ala Leu Glu Leu Ala
                245                 250                 255     
Lys Ala Lys Ala Val Arg Val Met Asn Thr His Ser Asp Asp Ser Gly
            260                 265                 270         
Asp Asp Asp Glu Ala Thr Thr Pro Ala Asp Lys Ser Glu Leu His His
        275                 280                 285             
Thr Leu Lys Asn Leu Ser Leu Lys Leu Asp Asp Leu Ser Thr Cys Asn
    290                 295                 300                 
Asp Leu Ile Ala Lys His Gly Ala Ala Leu Gln Arg Ser Leu Thr Glu
305                 310                 315                 320 
Leu Asp Gly Leu Lys Ile Pro Ser Glu Ser Gly Glu Lys Leu Lys Val
                325                 330                 335     
Val Asn Glu Arg Ala Thr Leu Phe Arg Ile Thr Ser Asn Ala Met Ile
            340                 345                 350         
Asn Ala Cys Arg Asp Phe Leu Glu Leu Ala Glu Ile His Ser Arg Lys
        355                 360                 365             
Trp Gln Arg Ala Leu Gln Tyr Glu Gln Glu Gln Arg Val His Leu Glu
    370                 375                 380                 
Glu Thr Ile Glu Gln Leu Ala Lys Gln His Asn Ser Leu Glu Arg Ala
385                 390                 395                 400 
Phe His Ser Ala Pro Gly Arg Pro Ala Asn Pro Ser Lys Ser Phe Ile
                405                 410                 415     
Glu Gly Ser Leu Leu Thr Pro Lys Gly Glu Asp Ser Glu Glu Asp Glu
            420                 425                 430         
Asp Thr Glu Tyr Phe Asp Ala Met Glu Asp Ser Thr Ser Phe Ile Thr
        435                 440                 445             
Val Ile Thr Glu Ala Lys Glu Asp Ser Arg Lys Ala Glu Gly Ser Thr
    450                 455                 460                 
Gly Thr Ser Ser Val Asp Trp Ser Ser Ala Asp Asn Val Leu Asp Gly
465                 470                 475                 480 
Ala Ser Leu Val Pro Lys Gly Ser Ser Lys Val Lys Arg Arg Val Arg
                485                 490                 495     
Ile Pro Asn Lys Pro Asn Tyr Ser Leu Asn Leu Trp Ser Ile Met Lys
            500                 505                 510         
Asn Cys Ile Gly Arg Glu Leu Ser Arg Ile Pro Met Pro Val Asn Phe
        515                 520                 525             
Asn Glu Pro Leu Ser Met Leu Gln Arg Leu Thr Glu Asp Leu Glu Tyr
    530                 535                 540                 
His His Leu Leu Asp Lys Ala Val His Cys Thr Ser Ser Val Glu Gln
545                 550                 555                 560 
Met Cys Leu Val Ala Ala Phe Ser Val Ser Ser Tyr Ser Thr Thr Val
                565                 570                 575     
His Arg Ile Ala Lys Pro Phe Asn Pro Met Leu Gly Glu Thr Phe Glu
            580                 585                 590         
Leu Asp Arg Leu Asp Asp Met Gly Leu Arg Ser Leu Cys Glu Gln Val
        595                 600                 605             
Ser His His Pro Pro Ser Ala Ala His Tyr Val Phe Ser Lys His Gly
    610                 615                 620                 
Trp Ser Leu Trp Gln Glu Ile Thr Ile Ser Ser Lys Phe Arg Gly Lys
625                 630                 635                 640 
Tyr Ile Ser Ile Met Pro Leu Gly Ala Ile His Leu Glu Phe Gln Ala
                645                 650                 655     
Ser Gly Asn His Tyr Val Trp Arg Lys Ser Thr Ser Thr Val His Asn
            660                 665                 670         
Ile Ile Val Gly Lys Leu Trp Ile Asp Gln Ser Gly Asp Ile Glu Ile
        675                 680                 685             
Val Asn His Lys Thr Asn Asp Arg Cys Gln Leu Lys Phe Leu Pro Tyr
    690                 695                 700                 
Ser Tyr Phe Ser Lys Glu Ala Ala Arg Lys Val Thr Gly Val Val Ser
705                 710                 715                 720 
Asp Ser Gln Gly Lys Ala His Tyr Val Leu Ser Gly Ser Trp Asp Glu
                725                 730                 735     
Gln Met Glu Cys Ser Lys Val Met His Ser Ser Pro Ser Ser Pro Ser
            740                 745                 750         
Ser Asp Gly Lys Gln Lys Thr Val Tyr Gln Thr Leu Ser Ala Lys Leu
        755                 760                 765             
Leu Trp Lys Lys Tyr Pro Leu Pro Glu Asn Ala Glu Asn Met Tyr Tyr
    770                 775                 780                 
Phe Ser Glu Leu Ala Leu Thr Leu Asn Glu His Glu Glu Gly Val Ala
785                 790                 795                 800 
Pro Thr Asp Ser Arg Leu Arg Pro Asp Gln Arg Leu Met Glu Lys Gly
                805                 810                 815     
Arg Trp Asp Glu Ala Asn Thr Glu Lys Gln Arg Leu Glu Glu Lys Gln
            820                 825                 830         
Arg Leu Ser Arg Arg Arg Arg Leu Glu Ala Cys Gly Pro Gly Ser Ser
        835                 840                 845             
Cys Ser Ser Glu Glu Glu Lys Glu Ala Asp Ala Tyr Thr Pro Leu Trp
    850                 855                 860                 
Phe Glu Lys Arg Leu Asp Pro Leu Thr Gly Glu Met Ala Cys Val Tyr
865                 870                 875                 880 
Lys Gly Gly Tyr Trp Glu Ala Lys Glu Lys Gln Asp Trp His Met Cys
                885                 890                 895     
Pro Asn Ile Phe
            900 


<210> 1503
<211> 421
<212> PRT
<213> Homo sapiens

<400> 1503
Met Ala Ala Thr Leu Ile Leu Glu Pro Ala Gly Arg Cys Cys Trp Asp
 1               5                  10                  15      
Glu Pro Val Arg Ile Ala Val Arg Gly Leu Ala Pro Glu Gln Pro Val
            20                  25                  30          
Thr Leu Arg Ala Ser Leu Arg Asp Glu Lys Gly Ala Leu Phe Gln Ala
        35                  40                  45              
His Ala Arg Tyr Arg Ala Asp Thr Leu Gly Glu Leu Asp Leu Glu Arg
    50                  55                  60                  
Ala Pro Ala Leu Gly Gly Ser Phe Ala Gly Leu Glu Pro Met Gly Leu
65                  70                  75                  80  
Leu Trp Ala Leu Glu Pro Glu Lys Pro Leu Val Arg Leu Val Lys Arg
                85                  90                  95      
Asp Val Arg Thr Pro Leu Ala Val Glu Leu Glu Val Leu Asp Gly His
            100                 105                 110         
Asp Pro Asp Pro Gly Arg Leu Leu Cys Gln Thr Arg His Glu Arg Tyr
        115                 120                 125             
Phe Leu Pro Pro Gly Val Arg Arg Glu Pro Val Arg Val Gly Arg Val
    130                 135                 140                 
Arg Gly Thr Leu Phe Leu Pro Pro Glu Pro Gly Pro Phe Pro Gly Ile
145                 150                 155                 160 
Val Asp Met Phe Gly Thr Gly Gly Gly Leu Leu Glu Tyr Arg Ala Ser
                165                 170                 175     
Leu Leu Ala Gly Lys Gly Phe Ala Val Met Ala Leu Ala Tyr Tyr Asn
            180                 185                 190         
Tyr Glu Asp Leu Pro Lys Thr Met Glu Thr Leu His Leu Glu Tyr Phe
        195                 200                 205             
Glu Glu Ala Met Asn Tyr Leu Leu Ser His Pro Glu Val Lys Gly Pro
    210                 215                 220                 
Gly Val Gly Leu Leu Gly Ile Ser Lys Gly Gly Glu Leu Cys Leu Ser
225                 230                 235                 240 
Met Ala Ser Phe Leu Lys Gly Ile Thr Ala Ala Val Val Ile Asn Gly
                245                 250                 255     
Ser Val Ala Asn Val Gly Gly Thr Leu Arg Tyr Lys Gly Glu Thr Leu
            260                 265                 270         
Pro Pro Val Gly Val Asn Arg Asn Arg Ile Lys Val Thr Lys Asp Gly
        275                 280                 285             
Tyr Ala Asp Ile Val Asp Val Leu Asn Ser Pro Leu Glu Gly Pro Asp
    290                 295                 300                 
Gln Lys Ser Phe Ile Pro Val Glu Arg Ala Glu Ser Thr Phe Leu Phe
305                 310                 315                 320 
Leu Val Gly Gln Asp Asp His Asn Trp Lys Ser Glu Phe Tyr Ala Asn
                325                 330                 335     
Glu Ala Cys Lys Arg Leu Gln Ala His Gly Arg Arg Lys Pro Gln Ile
            340                 345                 350         
Ile Cys Tyr Pro Glu Thr Gly His Tyr Ile Glu Pro Pro Tyr Phe Pro
        355                 360                 365             
Leu Cys Arg Ala Ser Leu His Ala Leu Val Gly Ser Pro Ile Ile Trp
    370                 375                 380                 
Gly Gly Glu Pro Arg Ala His Ala Met Ala Gln Val Asp Ala Trp Lys
385                 390                 395                 400 
Gln Leu Gln Thr Phe Phe His Lys His Leu Gly Gly Arg Glu Gly Thr
                405                 410                 415     
Ile Pro Ser Lys Val
            420     


<210> 1504
<211> 2406
<212> PRT
<213> Homo sapiens

<400> 1504
Met Asp Pro Glu Gln Ser Val Lys Gly Thr Lys Lys Ala Glu Gly Ser
 1               5                  10                  15      
Pro Arg Lys Arg Leu Thr Lys Gly Glu Ala Ile Gln Thr Ser Val Ser
            20                  25                  30          
Ser Ser Val Pro Tyr Pro Gly Ser Gly Thr Ala Pro Thr Gln Glu Ser
        35                  40                  45              
Pro Ala Gln Glu Leu Leu Ala Pro Gln Pro Phe Pro Gly Pro Ser Ser
    50                  55                  60                  
Val Leu Arg Glu Gly Ser Gln Glu Lys Thr Gly Gln Gln Gln Lys Pro
65                  70                  75                  80  
Pro Lys Arg Pro Pro Ile Glu Ala Ser Val His Ile Ser His Val Pro
                85                  90                  95      
Gln His Pro Leu Thr Pro Ala Phe Met Ser Pro Gly Lys Pro Glu His
            100                 105                 110         
Leu Leu Glu Gly Ser Thr Trp Gln Leu Val Ser Pro Met Arg Leu Gly
        115                 120                 125             
Pro Ser Gly Ser Leu Leu Ala Pro Gly Leu His Pro Gln Ser Gln Leu
    130                 135                 140                 
Leu Pro Ser His Ala Ser Ile Ile Pro Pro Glu Asp Leu Pro Gly Val
145                 150                 155                 160 
Pro Lys Val Phe Val Pro Arg Pro Ser Gln Val Ser Leu Lys Pro Thr
                165                 170                 175     
Glu Glu Ala His Lys Lys Glu Arg Lys Pro Gln Lys Pro Gly Lys Tyr
            180                 185                 190         
Ile Cys Gln Tyr Cys Ser Arg Pro Cys Ala Lys Pro Ser Val Leu Gln
        195                 200                 205             
Lys His Ile Arg Ser His Thr Gly Glu Arg Pro Tyr Pro Cys Gly Pro
    210                 215                 220                 
Cys Gly Phe Ser Phe Lys Thr Lys Ser Asn Leu Tyr Lys His Arg Lys
225                 230                 235                 240 
Ser His Ala His Arg Ile Lys Ala Gly Leu Ala Ser Gly Met Gly Gly
                245                 250                 255     
Glu Met Tyr Pro His Gly Leu Glu Met Glu Arg Ile Pro Gly Glu Glu
            260                 265                 270         
Phe Glu Glu Pro Thr Glu Gly Glu Ser Thr Asp Ser Glu Glu Glu Thr
        275                 280                 285             
Ser Ala Thr Ser Gly His Pro Ala Glu Leu Ser Pro Arg Pro Lys Gln
    290                 295                 300                 
Pro Leu Leu Ser Ser Gly Leu Tyr Ser Ser Gly Ser His Ser Ser Ser
305                 310                 315                 320 
His Glu Arg Cys Ser Leu Ser Gln Ser Ser Thr Ala Gln Ser Leu Glu
                325                 330                 335     
Asp Pro Pro Pro Phe Val Glu Pro Ser Ser Glu His Pro Leu Ser His
            340                 345                 350         
Lys Pro Glu Asp Thr His Thr Ile Lys Gln Lys Leu Ala Leu Arg Leu
        355                 360                 365             
Ser Glu Arg Lys Lys Val Ile Asp Glu Gln Ala Phe Leu Ser Pro Gly
    370                 375                 380                 
Ser Lys Gly Ser Thr Glu Ser Gly Tyr Phe Ser Arg Ser Glu Ser Ala
385                 390                 395                 400 
Glu Gln Gln Val Ser Pro Pro Asn Thr Asn Ala Lys Ser Tyr Ala Glu
                405                 410                 415     
Ile Ile Phe Gly Lys Cys Gly Arg Ile Gly Gln Arg Thr Ala Met Leu
            420                 425                 430         
Thr Ala Thr Ser Thr Gln Pro Leu Leu Pro Leu Ser Thr Glu Asp Lys
        435                 440                 445             
Pro Ser Leu Val Pro Leu Ser Val Pro Arg Thr Gln Val Ile Glu His
    450                 455                 460                 
Ile Thr Lys Leu Ile Thr Ile Asn Glu Ala Val Val Asp Thr Ser Glu
465                 470                 475                 480 
Ile Asp Ser Val Lys Pro Arg Arg Ser Ser Leu Ser Arg Arg Ser Ser
                485                 490                 495     
Met Glu Ser Pro Lys Ser Ser Leu Tyr Arg Glu Pro Leu Ser Ser His
            500                 505                 510         
Ser Glu Lys Thr Lys Pro Glu Gln Ser Leu Leu Ser Leu Gln His Pro
        515                 520                 525             
Pro Ser Thr Ala Pro Pro Val Pro Leu Leu Arg Ser His Ser Met Pro
    530                 535                 540                 
Ser Ala Ala Cys Thr Ile Ser Thr Pro His His Pro Phe Arg Gly Ser
545                 550                 555                 560 
Tyr Ser Phe Asp Asp His Ile Thr Asp Ser Glu Ala Leu Ser Arg Ser
                565                 570                 575     
Ser His Val Phe Thr Ser His Pro Arg Met Leu Lys Pro Gln Pro Ala
            580                 585                 590         
Ile Glu Leu Pro Leu Gly Gly Glu Tyr Ser Ser Glu Glu Pro Gly Pro
        595                 600                 605             
Ser Ser Lys Asp Thr Ala Ser Lys Pro Ser Asp Glu Val Glu Pro Lys
    610                 615                 620                 
Glu Ser Glu Leu Thr Lys Lys Thr Lys Lys Gly Leu Lys Thr Lys Gly
625                 630                 635                 640 
Val Ile Tyr Glu Cys Asn Ile Cys Gly Ala Arg Tyr Lys Lys Arg Asp
                645                 650                 655     
Asn Tyr Glu Ala His Lys Lys Tyr Tyr Cys Ser Glu Leu Gln Ile Ala
            660                 665                 670         
Lys Pro Ile Ser Ala Gly Thr His Thr Ser Pro Glu Ala Glu Lys Ser
        675                 680                 685             
Gln Ile Glu His Glu Pro Trp Ser Gln Met Met His Tyr Lys Leu Gly
    690                 695                 700                 
Thr Thr Leu Glu Leu Thr Pro Leu Arg Lys Arg Arg Lys Glu Lys Ser
705                 710                 715                 720 
Leu Gly Asp Glu Glu Glu Pro Pro Ala Phe Glu Ser Thr Lys Ser Gln
                725                 730                 735     
Phe Gly Ser Pro Gly Pro Ser Asp Ala Ala Arg Asn Leu Pro Leu Glu
            740                 745                 750         
Ser Thr Lys Ser Pro Ala Glu Pro Ser Lys Ser Val Pro Ser Leu Glu
        755                 760                 765             
Gly Pro Thr Gly Phe Gln Pro Arg Thr Pro Lys Pro Gly Ser Gly Ser
    770                 775                 780                 
Glu Ser Gly Lys Glu Arg Arg Thr Thr Ser Lys Glu Ile Ser Val Ile
785                 790                 795                 800 
Gln His Thr Ser Ser Phe Glu Lys Ser Asp Ser Leu Glu Gln Pro Ser
                805                 810                 815     
Gly Leu Glu Gly Glu Asp Lys Pro Leu Ala Gln Phe Pro Ser Pro Pro
            820                 825                 830         
Pro Ala Pro His Gly Arg Ser Ala His Ser Leu Gln Pro Lys Leu Val
        835                 840                 845             
Arg Gln Pro Asn Ile Gln Val Pro Glu Ile Leu Val Thr Glu Glu Pro
    850                 855                 860                 
Asp Arg Pro Asp Thr Glu Pro Glu Pro Pro Pro Lys Glu Pro Glu Lys
865                 870                 875                 880 
Thr Glu Glu Phe Gln Trp Pro Gln Arg Ser Gln Thr Leu Ala Gln Leu
                885                 890                 895     
Pro Ala Glu Lys Ala Pro Pro Lys Lys Lys Arg Leu Arg Leu Ala Glu
            900                 905                 910         
Met Ala Gln Ser Ser Gly Glu Ser Ser Phe Glu Ser Ser Val Pro Leu
        915                 920                 925             
Ser Arg Ser Pro Ser Gln Glu Ser Asn Val Ser Leu Ser Gly Ser Ser
    930                 935                 940                 
Arg Ser Ala Ser Phe Glu Arg Asp Asp His Gly Lys Ala Glu Ala Pro
945                 950                 955                 960 
Asp Pro Ser Ser Asp Met Arg Pro Lys Pro Leu Gly Thr His Met Leu
                965                 970                 975     
Thr Val Pro Ser His His Pro His Ala Arg Glu Met Arg Arg Ser Ala
            980                 985                 990         
Ser Glu Gln Ser Pro Asn Val Ser His Ser Ala His Met Thr Glu Thr
        995                 1000                1005            
Arg Ser Lys Ser Phe Asp Tyr Gly Ser Leu Ser Leu Thr Gly Pro Ser
    1010                1015                1020                
Ala Pro Ala Pro Val Ala Pro Pro Ala Gly Glu Ala Pro Pro Glu Arg
1025                1030                1035                1040
Arg Lys Cys Phe Leu Val Arg Ser Pro Ser Leu Ser Arg Pro Pro Glu
                1045                1050                1055    
Ser Glu Leu Glu Val Ala Pro Lys Gly Arg Gln Glu Ser Glu Glu Pro
            1060                1065                1070        
Gln Pro Ser Ser Ser Lys Pro Ser Ala Lys Ser Ser Leu Ser Gln Ile
        1075                1080                1085            
Ser Ser Ala Ala Thr Ser His Gly Gly Pro Pro Gly Gly Lys Gly Pro
    1090                1095                1100                
Gly Gln Asp Arg Pro Ala Leu Gly Pro Thr Val Pro Tyr Thr Glu Ala
1105                1110                1115                1120
Leu Gln Val Phe His His Pro Val Ala Gln Thr Pro Leu His Glu Lys
                1125                1130                1135    
Pro Tyr Leu Pro Pro Pro Val Ser Leu Phe Ser Phe Gln His Leu Val
            1140                1145                1150        
Gln His Glu Pro Gly Gln Ser Pro Glu Phe Phe Ser Thr Gln Ala Met
        1155                1160                1165            
Ser Ser Leu Leu Ser Ser Pro Tyr Ser Met Pro Pro Leu Pro Pro Ser
    1170                1175                1180                
Leu Phe Gln Ala Pro Pro Leu Pro Leu Gln Pro Thr Val Leu His Pro
1185                1190                1195                1200
Gly Gln Leu His Leu Pro Gln Leu Met Pro His Pro Ala Asn Ile Pro
                1205                1210                1215    
Phe Arg Gln Pro Pro Ser Phe Leu Pro Met Pro Tyr Pro Thr Ser Ser
            1220                1225                1230        
Ala Leu Ser Ser Gly Phe Phe Leu Pro Leu Gln Ser Gln Phe Ala Leu
        1235                1240                1245            
Gln Leu Pro Gly Asp Val Glu Ser His Leu Pro Gln Ile Lys Thr Ser
    1250                1255                1260                
Leu Ala Pro Leu Ala Thr Gly Ser Ala Gly Leu Ser Pro Ser Gln Glu
1265                1270                1275                1280
Tyr Ser Ser Asp Ile Arg Leu Pro Pro Val Ala Pro Pro Ala Ser Ser
                1285                1290                1295    
Ser Ala Pro Thr Ser Ala Pro Pro Leu Ala Leu Pro Ala Cys Pro Asp
            1300                1305                1310        
Thr Met Val Ser Leu Val Val Pro Val Arg Val Gln Thr Asn Met Pro
        1315                1320                1325            
Ser Tyr Gly Ser Ala Met Tyr Thr Thr Leu Ser Gln Ile Leu Val Thr
    1330                1335                1340                
Gln Ser Gln Gly Ser Ser Ala Thr Val Ala Leu Pro Lys Phe Glu Glu
1345                1350                1355                1360
Pro Pro Ser Lys Gly Thr Thr Val Cys Gly Ala Asp Val His Glu Val
                1365                1370                1375    
Gly Pro Gly Pro Ser Gly Leu Ser Glu Glu Gln Ser Arg Ala Phe Pro
            1380                1385                1390        
Thr Pro Tyr Leu Arg Val Pro Val Thr Leu Pro Glu Arg Lys Gly Thr
        1395                1400                1405            
Ser Leu Ser Ser Glu Ser Ile Leu Ser Leu Glu Gly Ser Ser Ser Thr
    1410                1415                1420                
Ala Gly Gly Ser Lys Arg Val Leu Ser Pro Ala Gly Ser Leu Glu Leu
1425                1430                1435                1440
Thr Met Glu Thr Gln Gln Gln Lys Arg Val Lys Glu Glu Glu Ala Ser
                1445                1450                1455    
Lys Ala Asp Glu Lys Leu Glu Leu Val Lys Pro Cys Ser Val Val Leu
            1460                1465                1470        
Thr Ser Thr Glu Asp Gly Lys Arg Pro Glu Lys Ser His Leu Gly Asn
        1475                1480                1485            
Gln Gly Gln Gly Arg Arg Glu Leu Glu Met Leu Ser Ser Leu Ser Ser
    1490                1495                1500                
Asp Pro Ser Asp Thr Lys Glu Ile Pro Pro Leu Pro His Pro Ala Leu
1505                1510                1515                1520
Ser His Gly Gln Ala Pro Gly Ser Glu Ala Leu Lys Glu Tyr Pro Gln
                1525                1530                1535    
Pro Ser Gly Lys Pro His Arg Arg Gly Leu Thr Pro Leu Ser Val Lys
            1540                1545                1550        
Lys Glu Asp Ser Lys Glu Gln Pro Asp Leu Pro Ser Leu Ala Pro Pro
        1555                1560                1565            
Ser Ser Leu Pro Leu Ser Glu Thr Ser Ser Arg Pro Ala Lys Ser Gln
    1570                1575                1580                
Glu Gly Thr Asp Ser Lys Lys Val Leu Gln Phe Pro Ser Leu His Thr
1585                1590                1595                1600
Thr Thr Asn Val Ser Trp Cys Tyr Leu Asn Tyr Ile Lys Pro Asn His
                1605                1610                1615    
Ile Gln His Ala Asp Arg Arg Ser Ser Val Tyr Ala Gly Trp Cys Ile
            1620                1625                1630        
Ser Leu Tyr Asn Pro Asn Leu Pro Gly Val Ser Thr Lys Ala Ala Leu
        1635                1640                1645            
Ser Leu Leu Arg Ser Lys Gln Lys Val Ser Lys Glu Thr Tyr Thr Met
    1650                1655                1660                
Ala Thr Ala Pro His Pro Glu Ala Gly Arg Leu Val Pro Ser Ser Ser
1665                1670                1675                1680
Arg Lys Pro Arg Met Thr Glu Val His Leu Pro Ser Leu Val Ser Pro
                1685                1690                1695    
Glu Gly Gln Lys Asp Leu Ala Arg Val Glu Lys Glu Glu Glu Arg Arg
            1700                1705                1710        
Gly Glu Pro Glu Glu Asp Ala Pro Ala Ser Gln Arg Gly Glu Pro Ala
        1715                1720                1725            
Arg Ile Lys Ile Phe Glu Gly Gly Tyr Lys Ser Asn Glu Glu Tyr Val
    1730                1735                1740                
Tyr Val Arg Gly Arg Gly Arg Gly Lys Tyr Val Cys Glu Glu Cys Gly
1745                1750                1755                1760
Ile Arg Cys Lys Lys Pro Ser Met Leu Lys Lys His Ile Arg Thr His
                1765                1770                1775    
Thr Asp Val Arg Pro Tyr Val Cys Lys His Cys His Phe Ala Phe Lys
            1780                1785                1790        
Thr Lys Gly Asn Leu Thr Lys His Met Lys Ser Lys Ala His Ser Lys
        1795                1800                1805            
Lys Cys Gln Glu Thr Gly Val Leu Glu Glu Leu Glu Ala Glu Glu Gly
    1810                1815                1820                
Thr Ser Asp Asp Leu Phe Gln Asp Ser Glu Gly Arg Glu Gly Ser Glu
1825                1830                1835                1840
Ala Val Glu Glu His Gln Phe Ser Asp Leu Glu Asp Ser Asp Ser Asp
                1845                1850                1855    
Ser Asp Leu Asp Glu Asp Glu Asp Glu Asp Glu Glu Glu Ser Gln Asp
            1860                1865                1870        
Glu Leu Ser Arg Pro Ser Ser Glu Ala Pro Pro Pro Gly Pro Pro His
        1875                1880                1885            
Ala Leu Arg Ala Asp Ser Ser Pro Ile Leu Gly Pro Gln Pro Pro Asp
    1890                1895                1900                
Ala Pro Ala Ser Gly Thr Glu Ala Thr Arg Gly Ser Ser Val Ser Glu
1905                1910                1915                1920
Ala Glu Arg Leu Thr Ala Ser Ser Cys Ser Met Ser Ser Gln Ser Met
                1925                1930                1935    
Pro Gly Leu Pro Trp Leu Gly Pro Ala Pro Leu Gly Ser Val Glu Lys
            1940                1945                1950        
Asp Thr Gly Ser Ala Leu Ser Tyr Lys Pro Val Ser Pro Arg Arg Pro
        1955                1960                1965            
Trp Ser Pro Ser Lys Glu Ala Gly Ser Arg Pro Pro Leu Ala Arg Lys
    1970                1975                1980                
His Ser Leu Thr Lys Asn Asp Ser Ser Pro Gln Arg Cys Ser Pro Ala
1985                1990                1995                2000
Arg Glu Pro Gln Ala Ser Ala Pro Ser Pro Pro Gly Leu His Val Asp
                2005                2010                2015    
Pro Gly Arg Gly Met Gly Pro Leu Pro Cys Gly Ser Pro Arg Leu Gln
            2020                2025                2030        
Leu Ser Pro Leu Thr Leu Cys Pro Leu Gly Arg Glu Leu Ala Pro Arg
        2035                2040                2045            
Ala His Val Leu Ser Lys Leu Glu Gly Thr Thr Asp Pro Gly Leu Pro
    2050                2055                2060                
Arg Tyr Ser Pro Thr Arg Arg Trp Ser Pro Gly Gln Ala Glu Ser Pro
2065                2070                2075                2080
Pro Arg Ser Ala Pro Pro Gly Lys Trp Ala Leu Ala Gly Pro Gly Ser
                2085                2090                2095    
Pro Ser Ala Gly Glu His Gly Pro Gly Leu Gly Leu Ala Pro Arg Val
            2100                2105                2110        
Leu Phe Pro Pro Ala Pro Leu Pro His Lys Leu Leu Ser Arg Ser Pro
        2115                2120                2125            
Glu Thr Cys Ala Ser Pro Trp Gln Lys Ala Glu Ser Arg Ser Pro Ser
    2130                2135                2140                
Cys Ser Pro Gly Pro Ala His Pro Leu Ser Ser Arg Pro Phe Ser Ala
2145                2150                2155                2160
Leu His Asp Phe His Gly His Ile Leu Ala Arg Thr Glu Glu Asn Ile
                2165                2170                2175    
Phe Ser His Leu Pro Leu His Ser Gln His Leu Thr Arg Ala Pro Cys
            2180                2185                2190        
Pro Leu Ile Pro Ile Gly Gly Ile Gln Met Val Gln Ala Arg Pro Gly
        2195                2200                2205            
Ala His Pro Thr Leu Leu Pro Gly Pro Thr Ala Ala Trp Val Ser Gly
    2210                2215                2220                
Phe Ser Gly Gly Gly Ser Asp Leu Thr Gly Ala Arg Glu Ala Gln Glu
2225                2230                2235                2240
Arg Gly Arg Trp Ser Pro Thr Glu Ser Ser Ser Ala Ser Val Ser Pro
                2245                2250                2255    
Val Ala Lys Val Ser Lys Phe Thr Leu Ser Ser Glu Leu Glu Gly Arg
            2260                2265                2270        
Asp Tyr Pro Lys Glu Arg Glu Arg Thr Gly Gly Gly Pro Gly Arg Pro
        2275                2280                2285            
Pro Asp Trp Thr Pro His Gly Thr Gly Ala Pro Ala Glu Pro Thr Pro
    2290                2295                2300                
Thr His Ser Pro Cys Thr Pro Pro Asp Thr Leu Pro Arg Pro Pro Gln
2305                2310                2315                2320
Gly Arg Arg Ala Ala Gln Ser Trp Ser Pro Arg Leu Glu Ser Pro Arg
                2325                2330                2335    
Ala Pro Ala Asn Pro Glu Pro Ser Ala Thr Pro Pro Leu Asp Arg Ser
            2340                2345                2350        
Ser Ser Val Gly Cys Leu Ala Glu Ala Ser Ala Arg Phe Pro Ala Arg
        2355                2360                2365            
Thr Arg Asn Leu Ser Gly Glu Ser Arg Thr Arg Gln Asp Ser Pro Lys
    2370                2375                2380                
Pro Ser Gly Ser Gly Glu Pro Arg Ala His Pro His Gln Pro Glu Asp
2385                2390                2395                2400
Arg Val Pro Pro Asn Ala
                2405    


<210> 1505
<211> 557
<212> PRT
<213> Homo sapiens

<400> 1505
Met Arg Arg Leu Thr Arg Arg Leu Val Leu Pro Val Phe Gly Val Leu
 1               5                  10                  15      
Trp Ile Thr Val Leu Leu Phe Phe Trp Val Thr Lys Arg Lys Leu Glu
            20                  25                  30          
Val Pro Thr Gly Pro Glu Val Gln Thr Pro Lys Val Trp Ser Leu Phe
        35                  40                  45              
Phe Lys Val Ala Gly Met Ser Pro Trp Ala Pro Gln Val Pro Val Ser
    50                  55                  60                  
Pro Thr Pro Pro Tyr Gln Arg Gly His Leu Pro Thr Gly Gly His Leu
65                  70                  75                  80  
Ala Val Cys His Phe Pro Cys Leu Leu Gln Glu Ala Gln Phe His Leu
                85                  90                  95      
Gln Thr Gln Val Phe Leu Gln Val Arg Cys Thr Leu Leu Val Tyr Cys
            100                 105                 110         
Thr Asp Leu Pro Pro Thr Ser Ile Ile Ile Thr Phe His Asn Glu Ala
        115                 120                 125             
Arg Ser Thr Leu Leu Arg Thr Ile Arg Ser Val Leu Asn Arg Thr Pro
    130                 135                 140                 
Thr His Leu Ile Arg Glu Ile Ile Leu Val Asp Asp Phe Ser Asn Asp
145                 150                 155                 160 
Pro Asp Asp Cys Lys Gln Leu Ile Lys Leu Pro Lys Val Lys Cys Leu
                165                 170                 175     
Arg Asn Asn Glu Arg Gln Gly Leu Val Arg Ser Arg Ile Arg Gly Ala
            180                 185                 190         
Asp Ile Ala Gln Gly Thr Thr Leu Thr Phe Leu Asp Ser His Cys Glu
        195                 200                 205             
Val Asn Arg Asp Trp Leu Gln Pro Leu Leu His Arg Val Lys Glu Asp
    210                 215                 220                 
Tyr Thr Arg Val Val Cys Pro Val Ile Asp Ile Ile Asn Leu Asp Thr
225                 230                 235                 240 
Phe Thr Tyr Ile Glu Ser Ala Ser Glu Leu Arg Gly Gly Phe Asp Trp
                245                 250                 255     
Ser Leu His Phe Gln Trp Glu Gln Leu Ser Pro Glu Gln Lys Ala Arg
            260                 265                 270         
Arg Leu Asp Pro Thr Glu Pro Ile Arg Thr Pro Ile Ile Ala Gly Gly
        275                 280                 285             
Leu Phe Val Ile Asp Lys Ala Trp Phe Asp Tyr Leu Gly Lys Tyr Asp
    290                 295                 300                 
Met Asp Met Asp Ile Trp Gly Gly Glu Asn Phe Glu Ile Ser Phe Arg
305                 310                 315                 320 
Val Trp Met Cys Gly Gly Ser Leu Glu Ile Val Pro Cys Ser Arg Val
                325                 330                 335     
Gly His Val Phe Arg Lys Lys His Pro Tyr Val Phe Pro Asp Gly Asn
            340                 345                 350         
Ala Asn Thr Tyr Ile Lys Asn Thr Lys Arg Thr Ala Glu Val Trp Met
        355                 360                 365             
Asp Glu Tyr Lys Gln Tyr Tyr Tyr Ala Ala Arg Pro Phe Ala Leu Glu
    370                 375                 380                 
Arg Pro Phe Gly Asn Val Glu Ser Arg Leu Asp Leu Arg Lys Asn Leu
385                 390                 395                 400 
Arg Cys Gln Ser Phe Lys Trp Tyr Leu Glu Asn Ile Tyr Pro Glu Leu
                405                 410                 415     
Ser Ile Pro Lys Glu Ser Ser Ile Gln Lys Gly Asn Ile Arg Gln Arg
            420                 425                 430         
Gln Lys Cys Leu Glu Ser Gln Arg Gln Asn Asn Gln Glu Thr Pro Asn
        435                 440                 445             
Leu Lys Leu Ser Pro Cys Ala Lys Val Lys Gly Glu Asp Ala Lys Ser
    450                 455                 460                 
Gln Val Trp Ala Phe Thr Tyr Thr Gln Gln Ile Leu Gln Glu Glu Leu
465                 470                 475                 480 
Cys Leu Ser Val Ile Thr Leu Phe Pro Gly Ala Pro Val Val Leu Val
                485                 490                 495     
Leu Cys Lys Asn Gly Asp Asp Arg Gln Gln Trp Thr Lys Thr Gly Ser
            500                 505                 510         
His Ile Glu His Ile Ala Ser His Leu Cys Leu Asp Thr Asp Met Phe
        515                 520                 525             
Gly Asp Gly Thr Glu Asn Gly Lys Glu Ile Val Val Asn Pro Cys Glu
    530                 535                 540                 
Ser Ser Leu Met Ser Gln His Trp Asp Met Val Ser Ser
545                 550                 555         


<210> 1506
<211> 665
<212> PRT
<213> Homo sapiens

<400> 1506
Met Thr Ser Ala Asn Lys Ala Ile Glu Leu Gln Leu Gln Val Lys Gln
 1               5                  10                  15      
Asn Ala Glu Glu Leu Gln Asp Phe Met Arg Asp Leu Glu Asn Trp Glu
            20                  25                  30          
Lys Asp Ile Lys Gln Lys Asp Met Glu Leu Arg Arg Gln Asn Gly Val
        35                  40                  45              
Pro Glu Glu Asn Leu Pro Pro Ile Arg Asn Gly Asn Phe Arg Lys Lys
    50                  55                  60                  
Lys Lys Gly Lys Ala Lys Glu Ser Ser Lys Lys Thr Arg Glu Glu Asn
65                  70                  75                  80  
Thr Lys Asn Arg Ile Lys Ser Tyr Asp Tyr Glu Ala Trp Ala Lys Leu
                85                  90                  95      
Asp Val Asp Arg Ile Leu Asp Glu Leu Asp Lys Asp Asp Ser Thr His
            100                 105                 110         
Glu Ser Leu Ser Gln Glu Ser Glu Ser Glu Glu Asp Gly Ile His Val
        115                 120                 125             
Asp Ser Gln Lys Ala Leu Val Leu Lys Glu Lys Gly Asn Lys Tyr Phe
    130                 135                 140                 
Lys Gln Gly Lys Tyr Asp Glu Ala Ile Asp Cys Tyr Thr Lys Gly Met
145                 150                 155                 160 
Asp Ala Asp Pro Tyr Asn Pro Val Leu Pro Thr Asn Arg Ala Ser Ala
                165                 170                 175     
Tyr Phe Arg Leu Lys Lys Phe Ala Val Ala Glu Ser Asp Cys Asn Leu
            180                 185                 190         
Ala Val Ala Leu Asn Arg Ser Tyr Thr Lys Ala Tyr Ser Arg Arg Gly
        195                 200                 205             
Ala Ala Arg Phe Ala Leu Gln Lys Leu Glu Glu Ala Lys Lys Asp Tyr
    210                 215                 220                 
Glu Arg Val Leu Glu Leu Glu Pro Asn Asn Phe Glu Ala Thr Asn Glu
225                 230                 235                 240 
Leu Arg Lys Ile Ser Gln Ala Leu Ala Ser Lys Glu Asn Ser Tyr Pro
                245                 250                 255     
Lys Glu Ala Asp Ile Val Ile Lys Ser Thr Glu Gly Glu Arg Lys Gln
            260                 265                 270         
Ile Glu Ala Gln Gln Asn Lys Gln Gln Ala Ile Ser Glu Lys Asp Arg
        275                 280                 285             
Gly Asn Gly Phe Phe Lys Glu Gly Lys Tyr Glu Arg Ala Ile Glu Cys
    290                 295                 300                 
Tyr Thr Arg Gly Ile Ala Ala Asp Gly Ala Asn Ala Leu Leu Pro Ala
305                 310                 315                 320 
Asn Arg Ala Met Ala Tyr Leu Lys Ile Gln Lys Tyr Glu Glu Ala Glu
                325                 330                 335     
Lys Asp Cys Thr Gln Ala Ile Leu Leu Asp Gly Ser Tyr Ser Lys Ala
            340                 345                 350         
Phe Ala Arg Arg Gly Thr Ala Arg Thr Phe Leu Gly Lys Leu Asn Glu
        355                 360                 365             
Ala Lys Gln Asp Phe Glu Thr Val Leu Leu Leu Glu Pro Gly Asn Lys
    370                 375                 380                 
Gln Ala Val Thr Glu Leu Ser Lys Ile Lys Lys Glu Leu Ile Glu Lys
385                 390                 395                 400 
Gly His Trp Asp Asp Val Phe Leu Asp Ser Thr Gln Arg Gln Asn Val
                405                 410                 415     
Val Lys Pro Ile Asp Asn Pro Pro His Pro Gly Ser Thr Lys Pro Leu
            420                 425                 430         
Lys Lys Val Ile Ile Glu Glu Thr Gly Asn Leu Ile Gln Thr Ile Asp
        435                 440                 445             
Val Pro Asp Ser Thr Thr Ala Ala Ala Pro Glu Asn Asn Pro Ile Asn
    450                 455                 460                 
Leu Ala Asn Val Ile Ala Ala Thr Gly Thr Thr Ser Lys Lys Asn Ser
465                 470                 475                 480 
Ser Gln Asp Val Leu Phe Pro Thr Ser Asp Thr Pro Arg Ala Lys Val
                485                 490                 495     
Leu Lys Ile Glu Glu Val Ser Asp Thr Ser Ser Leu Gln Pro Gln Ala
            500                 505                 510         
Ser Leu Lys Gln Asp Val Cys Gln Ser Tyr Ser Glu Lys Met Pro Ile
        515                 520                 525             
Glu Ile Glu Gln Lys Pro Ala Gln Phe Ala Thr Thr Val Leu Pro Pro
    530                 535                 540                 
Ile Pro Ala Asn Ser Phe Gln Leu Glu Ser Asp Phe Arg Gln Leu Lys
545                 550                 555                 560 
Ser Ser Pro Asp Met Leu Tyr Gln Tyr Leu Lys Gln Ile Glu Pro Ser
                565                 570                 575     
Leu Tyr Pro Lys Leu Phe Gln Lys Asn Leu Asp Pro Asp Val Phe Asn
            580                 585                 590         
Gln Ile Val Lys Ile Leu His Asp Phe Tyr Ile Glu Lys Glu Lys Pro
        595                 600                 605             
Leu Leu Ile Phe Glu Ile Leu Gln Arg Leu Ser Glu Leu Lys Arg Phe
    610                 615                 620                 
Asp Met Ala Val Met Phe Met Ser Glu Thr Glu Lys Lys Ile Ala Arg
625                 630                 635                 640 
Ala Leu Phe Asn His Ile Asp Lys Ser Gly Leu Lys Asp Ser Ser Val
                645                 650                 655     
Glu Glu Leu Lys Lys Arg Tyr Gly Gly
            660                 665 


<210> 1507
<211> 390
<212> PRT
<213> Homo sapiens

<400> 1507
Met Pro Glu Gly Pro Glu Leu His Leu Ala Ser Gln Phe Val Asn Glu
 1               5                  10                  15      
Ala Cys Arg Ala Leu Val Phe Gly Gly Cys Val Glu Lys Ser Ser Val
            20                  25                  30          
Ser Arg Asn Pro Glu Val Pro Phe Glu Ser Ser Ala Tyr Arg Ile Ser
        35                  40                  45              
Ala Ser Ala Arg Gly Lys Glu Leu Arg Leu Ile Leu Ser Pro Leu Pro
    50                  55                  60                  
Gly Ala Gln Pro Gln Gln Glu Pro Leu Ala Leu Val Phe Arg Phe Gly
65                  70                  75                  80  
Met Ser Gly Ser Phe Gln Leu Val Pro Arg Glu Glu Leu Pro Arg His
                85                  90                  95      
Ala His Leu Arg Phe Tyr Thr Ala Pro Pro Gly Pro Arg Leu Ala Leu
            100                 105                 110         
Cys Phe Val Asp Ile Arg Arg Phe Gly Arg Trp Asp Leu Gly Gly Lys
        115                 120                 125             
Trp Gln Pro Gly Arg Gly Pro Cys Val Leu Gln Glu Tyr Gln Gln Phe
    130                 135                 140                 
Arg Glu Ser Val Leu Arg Asn Leu Ala Asp Lys Ala Phe Asp Arg Pro
145                 150                 155                 160 
Ile Cys Glu Ala Leu Leu Asp Gln Arg Phe Phe Asn Gly Ile Gly Asn
                165                 170                 175     
Tyr Leu Arg Ala Glu Ile Leu Tyr Arg Leu Lys Ile Pro Pro Phe Glu
            180                 185                 190         
Lys Ala Arg Ser Val Leu Glu Ala Leu Gln Gln His Arg Pro Ser Pro
        195                 200                 205             
Glu Leu Thr Leu Ser Gln Lys Ile Arg Thr Lys Leu Gln Asn Pro Asp
    210                 215                 220                 
Leu Leu Glu Leu Cys His Ser Val Pro Lys Glu Val Val Gln Leu Gly
225                 230                 235                 240 
Gly Arg Gly Tyr Gly Ser Glu Ser Gly Glu Glu Asp Phe Ala Ala Phe
                245                 250                 255     
Arg Ala Trp Leu Arg Cys Tyr Gly Met Pro Gly Met Ser Ser Leu Gln
            260                 265                 270         
Asp Arg His Gly Arg Thr Ile Trp Phe Gln Gly Asp Pro Gly Pro Leu
        275                 280                 285             
Ala Pro Lys Gly Arg Lys Ser Arg Lys Lys Lys Ser Lys Ala Thr Gln
    290                 295                 300                 
Leu Ser Pro Glu Asp Arg Val Glu Asp Ala Leu Pro Pro Ser Lys Ala
305                 310                 315                 320 
Pro Ser Arg Thr Arg Arg Ala Lys Arg Asp Leu Pro Lys Arg Thr Ala
                325                 330                 335     
Thr Gln Arg Pro Glu Gly Thr Ser Leu Gln Gln Asp Pro Glu Ala Pro
            340                 345                 350         
Thr Val Pro Lys Lys Gly Arg Arg Lys Gly Arg Gln Ala Ala Ser Gly
        355                 360                 365             
His Cys Arg Pro Arg Lys Val Lys Ala Asp Ile Pro Ser Leu Glu Pro
    370                 375                 380                 
Glu Gly Thr Ser Ala Ser
385                 390 


<210> 1508
<211> 554
<212> PRT
<213> Homo sapiens

<400> 1508
Met Ala Tyr Ala Ala Arg Thr Met Gly Lys Leu Ala Tyr Glu Gly Val
 1               5                  10                  15      
Ser Ser Arg Lys Thr Tyr Phe Ser Glu Glu Asp Val Cys Gly Cys Leu
            20                  25                  30          
Glu Ala Gly Ile Arg Thr Glu Glu Glu Phe Gln Leu Leu His Ile Phe
        35                  40                  45              
Arg Arg Asp Ala Leu Arg Phe Phe Leu Ala Pro Cys Val Glu Pro Gly
    50                  55                  60                  
Arg Ala Gly Thr Phe Val Phe Thr Val Pro Ala Met Gln Glu Tyr Leu
65                  70                  75                  80  
Ala Ala Leu Tyr Ile Val Leu Gly Leu Arg Lys Thr Thr Leu Gln Lys
                85                  90                  95      
Val Gly Lys Glu Val Ala Glu Leu Val Gly Arg Val Gly Glu Asp Val
            100                 105                 110         
Ser Leu Val Leu Gly Ile Met Ala Lys Leu Leu Pro Leu Arg Ala Leu
        115                 120                 125             
Pro Leu Leu Phe Asn Leu Ile Lys Val Val Pro Arg Val Phe Gly Arg
    130                 135                 140                 
Met Val Gly Lys Ser Arg Glu Ala Val Ala Gln Ala Met Val Leu Glu
145                 150                 155                 160 
Met Phe Arg Glu Glu Asp Tyr Tyr Asn Asp Asp Val Leu Asp Gln Met
                165                 170                 175     
Gly Ala Ser Ile Leu Gly Val Glu Gly Pro Arg Arg His Pro Asp Glu
            180                 185                 190         
Pro Pro Glu Asp Glu Val Phe Glu Leu Phe Pro Met Phe Met Gly Gly
        195                 200                 205             
Leu Leu Ser Ala His Asn Arg Ala Val Leu Ala Gln Leu Gly Cys Pro
    210                 215                 220                 
Ile Lys Asn Leu Asp Ala Leu Glu Asn Ala Gln Ala Ile Lys Lys Lys
225                 230                 235                 240 
Leu Gly Lys Leu Gly Arg Gln Val Leu Pro Pro Ser Glu Leu Leu Asp
                245                 250                 255     
His Leu Phe Phe His Tyr Glu Phe Gln Asn Gln Arg Phe Ser Ala Glu
            260                 265                 270         
Val Leu Ser Ser Leu Arg Gln Leu Asn Leu Ala Gly Val Arg Met Thr
        275                 280                 285             
Pro Val Lys Cys Thr Val Val Ala Ala Val Leu Gly Ser Gly Arg His
    290                 295                 300                 
Ala Leu Asp Glu Val Asn Leu Ala Ser Cys Gln Leu Asp Pro Ala Gly
305                 310                 315                 320 
Leu Arg Thr Leu Leu Pro Val Phe Leu Arg Ala Arg Lys Leu Gly Leu
                325                 330                 335     
Gln Leu Asn Ser Leu Gly Pro Glu Ala Cys Lys Asp Leu Arg Asp Leu
            340                 345                 350         
Leu Leu His Asp Gln Cys Gln Ile Thr Thr Leu Arg Leu Ser Asn Asn
        355                 360                 365             
Pro Leu Thr Glu Ala Gly Val Ala Val Leu Met Glu Gly Leu Ala Gly
    370                 375                 380                 
Asn Thr Ser Val Thr His Leu Ser Leu Leu His Thr Gly Leu Gly Asp
385                 390                 395                 400 
Glu Gly Leu Glu Leu Leu Ala Ala Gln Leu Asp Arg Asn Arg Gln Leu
                405                 410                 415     
Gln Glu Leu Asn Val Ala Tyr Asn Gly Ala Gly Asp Thr Ala Ala Leu
            420                 425                 430         
Ala Leu Ala Arg Ala Ala Arg Glu His Pro Ser Leu Glu Leu Leu His
        435                 440                 445             
Leu Tyr Phe Asn Glu Leu Ser Ser Glu Gly Arg Gln Val Leu Arg Asp
    450                 455                 460                 
Leu Gly Gly Ala Ala Glu Gly Gly Ala Arg Val Val Val Ser Leu Thr
465                 470                 475                 480 
Glu Gly Thr Ala Val Ser Glu Tyr Trp Ser Val Ile Leu Ser Glu Val
                485                 490                 495     
Gln Arg Asn Leu Asn Ser Trp Asp Arg Ala Arg Val Gln Arg His Leu
            500                 505                 510         
Glu Leu Leu Leu Arg Asp Leu Glu Asp Ser Arg Gly Ala Thr Leu Asn
        515                 520                 525             
Pro Trp Arg Lys Ala Gln Leu Leu Arg Val Glu Gly Glu Val Arg Ala
    530                 535                 540                 
Leu Leu Glu Gln Leu Gly Ser Ser Gly Ser
545                 550                 


<210> 1509
<211> 415
<212> PRT
<213> Homo sapiens

<400> 1509
Met Lys Leu Ser Leu Thr Lys Val Val Asn Gly Cys Arg Leu Gly Lys
 1               5                  10                  15      
Ile Lys Asn Leu Gly Lys Thr Gly Asp His Thr Met Asp Ile Pro Gly
            20                  25                  30          
Cys Leu Leu Tyr Thr Lys Thr Gly Ser Ala Pro His Leu Thr His His
        35                  40                  45              
Thr Leu His Asn Ile His Gly Val Pro Ala Met Ala Gln Leu Thr Leu
    50                  55                  60                  
Ser Ser Leu Ala Glu His His Glu Val Leu Thr Glu Tyr Lys Glu Gly
65                  70                  75                  80  
Val Gly Lys Phe Ile Gly Met Pro Glu Ser Leu Leu Tyr Cys Ser Leu
                85                  90                  95      
His Asp Pro Val Ser Pro Cys Pro Ala Gly Tyr Val Thr Asn Lys Ser
            100                 105                 110         
Val Ser Val Trp Ser Val Ala Gly Arg Val Glu Met Thr Val Ser Lys
        115                 120                 125             
Phe Met Ala Ile Gln Lys Ala Leu Gln Pro Asp Trp Phe Gln Cys Leu
    130                 135                 140                 
Ser Asp Gly Glu Val Ser Cys Lys Glu Ala Thr Ser Ile Lys Arg Val
145                 150                 155                 160 
Arg Lys Ser Val Asp Arg Ser Leu Leu Phe Leu Asp Asn Cys Leu Arg
                165                 170                 175     
Leu Gln Glu Glu Ser Glu Val Leu Gln Lys Ser Val Ile Ile Gly Val
            180                 185                 190         
Ile Glu Gly Gly Asp Val Met Glu Glu Arg Leu Arg Ser Ala Arg Glu
        195                 200                 205             
Thr Ala Lys Arg Pro Val Gly Gly Phe Leu Leu Asp Gly Phe Gln Gly
    210                 215                 220                 
Asn Pro Thr Thr Leu Glu Ala Arg Leu Arg Leu Leu Ser Ser Val Thr
225                 230                 235                 240 
Ala Glu Leu Pro Glu Asp Lys Pro Arg Leu Ile Ser Gly Val Ser Arg
                245                 250                 255     
Pro Asp Glu Val Leu Glu Cys Ile Glu Arg Gly Val Asp Leu Phe Glu
            260                 265                 270         
Ser Phe Phe Pro Tyr Gln Val Thr Glu Arg Gly Cys Ala Leu Thr Phe
        275                 280                 285             
Ser Phe Asp Tyr Gln Pro Asn Pro Glu Glu Thr Leu Leu Gln Gln Asn
    290                 295                 300                 
Gly Thr Gln Glu Glu Ile Lys Cys Met Asp Gln Ile Lys Lys Ile Glu
305                 310                 315                 320 
Thr Thr Gly Cys Asn Gln Glu Ile Thr Ser Phe Glu Ile Asn Leu Lys
                325                 330                 335     
Glu Lys Lys Tyr Gln Glu Asp Phe Asn Pro Leu Val Arg Gly Cys Ser
            340                 345                 350         
Cys Tyr Cys Cys Lys Asn His Thr Arg Ala Tyr Ile His His Leu Leu
        355                 360                 365             
Val Thr Asn Glu Leu Leu Ala Gly Val Leu Leu Met Met His Asn Phe
    370                 375                 380                 
Glu His Tyr Phe Gly Phe Phe His Tyr Ile Arg Glu Ala Leu Lys Ser
385                 390                 395                 400 
Asp Lys Leu Ala Gln Leu Lys Glu Leu Ile His Arg Gln Ala Ser
                405                 410                 415 


<210> 1510
<211> 520
<212> PRT
<213> Homo sapiens

<400> 1510
Met Arg Ser Pro Glu Gly Tyr Leu Arg Gly Asn Met Ser Glu Asn Glu
 1               5                  10                  15      
Glu Glu Glu Ile Ser Gln Gln Glu Gly Ser Gly Asp Tyr Glu Val Glu
            20                  25                  30          
Glu Ile Pro Phe Gly Leu Glu Pro Gln Ser Pro Gly Phe Glu Pro Gln
        35                  40                  45              
Ser Pro Glu Phe Glu Pro Gln Ser Pro Arg Phe Glu Pro Glu Ser Pro
    50                  55                  60                  
Gly Phe Glu Ser Arg Ser Pro Gly Leu Val Pro Pro Ser Pro Glu Phe
65                  70                  75                  80  
Ala Pro Arg Ser Pro Glu Ser Asp Ser Gln Ser Pro Glu Phe Glu Ser
                85                  90                  95      
Gln Ser Pro Arg Tyr Glu Pro Gln Ser Pro Gly Tyr Glu Pro Arg Ser
            100                 105                 110         
Pro Gly Tyr Glu Pro Arg Ser Pro Gly Tyr Glu Ser Glu Ser Ser Arg
        115                 120                 125             
Tyr Glu Ser Gln Asn Thr Glu Leu Lys Thr Gln Ser Pro Glu Phe Glu
    130                 135                 140                 
Ala Gln Ser Ser Lys Phe Gln Glu Gly Ala Glu Met Leu Leu Asn Pro
145                 150                 155                 160 
Glu Glu Lys Ser Pro Leu Asn Ile Ser Val Gly Val His Pro Leu Asp
                165                 170                 175     
Ser Phe Thr Gln Gly Phe Gly Glu Gln Pro Thr Gly Asp Leu Pro Ile
            180                 185                 190         
Gly Pro Pro Phe Glu Met Pro Thr Gly Ala Leu Leu Ser Thr Pro Gln
        195                 200                 205             
Phe Glu Met Leu Gln Asn Pro Leu Gly Leu Thr Gly Ala Leu Arg Gly
    210                 215                 220                 
Pro Gly Arg Arg Gly Gly Arg Ala Arg Gly Gly Gln Gly Pro Arg Pro
225                 230                 235                 240 
Asn Ile Cys Gly Ile Cys Gly Lys Ser Phe Gly Arg Gly Ser Thr Leu
                245                 250                 255     
Ile Gln His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu
            260                 265                 270         
Val Cys Ser Lys Ala Phe Ser Gln Ser Ser Asp Leu Ile Lys His Gln
        275                 280                 285             
Arg Thr His Thr Gly Glu Arg Pro Tyr Lys Cys Pro Arg Cys Gly Lys
    290                 295                 300                 
Ala Phe Ala Asp Ser Ser Tyr Leu Leu Arg His Gln Arg Thr His Ser
305                 310                 315                 320 
Gly Gln Lys Pro Tyr Lys Cys Pro His Cys Gly Lys Ala Phe Gly Asp
                325                 330                 335     
Ser Ser Tyr Leu Leu Arg His Gln Arg Thr His Ser His Glu Arg Pro
            340                 345                 350         
Tyr Ser Cys Thr Glu Cys Gly Lys Cys Tyr Ser Gln Asn Ser Ser Leu
        355                 360                 365             
Arg Ser His Gln Arg Val His Thr Gly Gln Arg Pro Phe Ser Cys Gly
    370                 375                 380                 
Ile Cys Gly Lys Ser Phe Ser Gln Arg Ser Ala Leu Ile Pro His Ala
385                 390                 395                 400 
Arg Ser His Ala Arg Glu Lys Pro Phe Lys Cys Pro Glu Cys Gly Lys
                405                 410                 415     
Arg Phe Gly Gln Ser Ser Val Leu Ala Ile His Ala Arg Thr His Leu
            420                 425                 430         
Pro Gly Arg Thr Tyr Ser Cys Pro Asp Cys Gly Lys Thr Phe Asn Arg
        435                 440                 445             
Ser Ser Thr Leu Ile Gln His Gln Arg Ser His Thr Gly Glu Arg Pro
    450                 455                 460                 
Tyr Arg Cys Ala Val Cys Gly Lys Gly Phe Cys Arg Ser Ser Thr Leu
465                 470                 475                 480 
Leu Gln His His Arg Val His Ser Gly Glu Arg Pro Tyr Lys Cys Asp
                485                 490                 495     
Asp Cys Gly Lys Ala Phe Ser Gln Ser Ser Asp Leu Ile Arg His Gln
            500                 505                 510         
Arg Thr His Ala Ala Gly Arg Arg
        515                 520 


<210> 1511
<211> 590
<212> PRT
<213> Homo sapiens

<400> 1511
Met Leu Ser Leu Lys Gln Leu Leu Ser Phe Leu Ser Ile Thr Asp Phe
 1               5                  10                  15      
Gln Leu Pro Asp Glu Asp Phe Gly Pro Leu Lys Leu Glu Lys Val Lys
            20                  25                  30          
Ser Cys Ser Glu Lys Pro Val Glu Pro Phe Glu Ser Lys Met Phe Gly
        35                  40                  45              
Glu Arg His Leu Lys Glu Gly Ser Cys Ile Phe Pro Glu Glu Leu Ser
    50                  55                  60                  
Pro Lys Arg Met Asp Thr Glu Met Glu Asp Leu Glu Glu Asp Leu Ile
65                  70                  75                  80  
Val Leu Pro Gly Lys Ser His Pro Lys Arg Pro Asn Ser Gln Ser Gln
                85                  90                  95      
His Thr Lys Thr Gly Leu Ser Ser Ser Ile Leu Leu Tyr Thr Pro Leu
            100                 105                 110         
Asn Thr Val Ala Pro Asp Asp Asn Asp Arg Pro Thr Thr Asp Met Cys
        115                 120                 125             
Ser Pro Ala Phe Pro Ile Leu Gly Thr Thr Pro Ala Phe Gly Pro Gln
    130                 135                 140                 
Gly Ser Tyr Glu Lys Ala Ser Thr Glu Val Ala Gly Arg Thr Cys Cys
145                 150                 155                 160 
Thr Pro Gln Leu Ala His Leu Lys Asp Ser Val Cys Leu Ala Ser Asp
                165                 170                 175     
Thr Lys Gln Phe Asp Ser Ser Gly Ser Pro Ala Lys Pro His Thr Thr
            180                 185                 190         
Leu Gln Val Ser Gly Arg Gln Gly Gln Pro Thr Cys Asp Cys Asp Ser
        195                 200                 205             
Val Pro Pro Gly Thr Pro Pro Pro Ile Glu Ser Phe Thr Phe Lys Glu
    210                 215                 220                 
Asn Gln Leu Cys Arg Asn Thr Cys Gln Glu Leu His Lys His Ser Val
225                 230                 235                 240 
Glu Gln Thr Glu Thr Ala Glu Leu Pro Ala Ser Asp Ser Ile Asn Pro
                245                 250                 255     
Gly Asn Leu Gln Leu Val Ser Glu Leu Lys Asn Pro Ser Gly Ser Cys
            260                 265                 270         
Ser Val Asp Val Ser Ala Met Phe Trp Glu Arg Ala Gly Cys Lys Glu
        275                 280                 285             
Pro Cys Ile Ile Thr Ala Cys Glu Asp Val Val Ser Leu Trp Lys Ala
    290                 295                 300                 
Leu Asp Ala Trp Gln Trp Glu Lys Leu Tyr Thr Trp His Phe Ala Glu
305                 310                 315                 320 
Val Pro Val Leu Gln Ile Val Pro Val Pro Asp Val Tyr Asn Leu Val
                325                 330                 335     
Cys Val Ala Leu Gly Asn Leu Glu Ile Arg Glu Ile Arg Ala Leu Phe
            340                 345                 350         
Cys Ser Ser Asp Asp Glu Ser Glu Lys Gln Val Leu Leu Lys Ser Gly
        355                 360                 365             
Asn Ile Lys Ala Val Leu Gly Leu Thr Lys Arg Arg Leu Val Ser Ser
    370                 375                 380                 
Ser Gly Thr Leu Ser Asp Gln Gln Val Glu Val Met Thr Phe Ala Glu
385                 390                 395                 400 
Asp Gly Gly Gly Lys Glu Asn Gln Phe Leu Met Pro Pro Glu Glu Thr
                405                 410                 415     
Ile Leu Thr Phe Ala Glu Val Gln Gly Met Gln Glu Ala Leu Leu Gly
            420                 425                 430         
Thr Thr Ile Met Asn Asn Ile Val Ile Trp Asn Leu Lys Thr Gly Gln
        435                 440                 445             
Leu Leu Lys Lys Met His Ile Asp Asp Ser Tyr Gln Ala Ser Val Cys
    450                 455                 460                 
His Lys Ala Tyr Ser Glu Met Gly Leu Leu Phe Ile Val Leu Ser His
465                 470                 475                 480 
Pro Cys Ala Lys Glu Ser Glu Ser Leu Arg Ser Pro Val Phe Gln Leu
                485                 490                 495     
Ile Val Ile Asn Pro Lys Thr Thr Leu Ser Val Gly Val Met Leu Tyr
            500                 505                 510         
Cys Leu Pro Pro Gly Gln Ala Gly Arg Phe Leu Glu Gly Asp Val Lys
        515                 520                 525             
Asp His Cys Ala Ala Ala Ile Leu Thr Ser Gly Thr Ile Ala Ile Trp
    530                 535                 540                 
Asp Leu Leu Leu Gly Gln Cys Thr Ala Leu Leu Pro Pro Val Ser Asp
545                 550                 555                 560 
Gln His Trp Ser Phe Val Lys Trp Ser Gly Thr Asp Ser His Leu Leu
                565                 570                 575     
Ala Gly Gln Lys Asp Gly Asn Ile Phe Val Tyr His Tyr Ser
            580                 585                 590 


<210> 1512
<211> 207
<212> PRT
<213> Homo sapiens

<400> 1512
Met Lys Cys Thr Leu Val Arg Gly Asp Ser Ser Pro Arg Gln Ala Glu
 1               5                  10                  15      
Leu Lys Ser Gly Pro Ala Ser Arg Pro Ala Leu Glu Lys Pro His Pro
            20                  25                  30          
His Glu Glu Ala Thr Thr Leu Pro Glu Glu Ala Pro Ser Asn Asp Glu
        35                  40                  45              
Arg Thr Pro Glu Glu Glu Ala Pro Pro Asn Glu Gln Arg Pro Leu Arg
    50                  55                  60                  
Glu Glu Val Leu Pro Lys Glu Gly Val Ala Ser Lys Glu Glu Val Thr
65                  70                  75                  80  
Leu Lys Glu Glu Leu Pro Pro Lys Glu Glu Val Ala Pro Lys Glu Glu
                85                  90                  95      
Val Pro Pro Ile Glu Arg Ala Phe Ala Gln Lys Thr Arg Pro Ile Lys
            100                 105                 110         
Pro Pro Pro Asp Ser Gln Glu Thr Leu Ala Leu Pro Ser Leu Val Pro
        115                 120                 125             
Gln Asn Tyr Thr Glu Asn Lys Asn Glu Gly Val Asp Val Thr Ser Leu
    130                 135                 140                 
Arg Gly Glu Val Glu Ser Leu Arg Arg Ala Leu Glu Leu Met Glu Val
145                 150                 155                 160 
Gln Leu Glu Arg Lys Leu Thr Asp Ile Trp Glu Glu Leu Lys Ser Glu
                165                 170                 175     
Lys Glu Gln Arg Arg Arg Leu Glu Val Gln Val Met Gln Gly Thr Gln
            180                 185                 190         
Lys Ser Gln Thr Pro Arg Val Ile His Thr Gln Thr Gln Thr Tyr
        195                 200                 205         


<210> 1513
<211> 221
<212> PRT
<213> Homo sapiens

<400> 1513
Met Ala Ala Ala Arg Pro Ser Leu Gly Arg Val Leu Pro Gly Ser Ser
 1               5                  10                  15      
Val Leu Phe Leu Cys Asp Met Gln Glu Lys Phe Arg His Asn Ile Ala
            20                  25                  30          
Tyr Phe Pro Gln Ile Val Ser Val Ala Ala Arg Met Leu Lys Val Ala
        35                  40                  45              
Arg Leu Leu Glu Val Pro Val Met Leu Thr Glu Gln Tyr Pro Gln Gly
    50                  55                  60                  
Leu Gly Pro Thr Val Pro Glu Leu Gly Thr Glu Gly Leu Arg Pro Leu
65                  70                  75                  80  
Ala Lys Thr Cys Phe Ser Met Val Pro Ala Leu Gln Gln Glu Leu Asp
                85                  90                  95      
Ser Arg Pro Gln Leu Arg Ser Val Leu Leu Cys Gly Ile Glu Ala Gln
            100                 105                 110         
Ala Cys Ile Leu Asp Pro Arg Ser Tyr Pro Gly Leu Ala Leu Thr Ser
        115                 120                 125             
Leu Tyr Pro Gln Asn Thr Thr Leu Asp Leu Leu Asp Arg Gly Leu Gln
    130                 135                 140                 
Val His Val Val Val Asp Ala Cys Ser Ser Arg Ser Gln Val Asp Arg
145                 150                 155                 160 
Leu Val Ala Leu Ala Arg Met Arg Gln Ser Gly Ala Phe Leu Ser Thr
                165                 170                 175     
Ser Glu Gly Leu Ile Leu Gln Leu Val Gly Asp Ala Val His Pro Gln
            180                 185                 190         
Phe Lys Glu Ile Gln Lys Leu Ile Lys Glu Pro Ala Pro Asp Ser Gly
        195                 200                 205             
Leu Leu Gly Leu Phe Gln Gly Gln Asn Ser Leu Leu His
    210                 215                 220     


<210> 1514
<211> 607
<212> PRT
<213> Homo sapiens

<400> 1514
Met Ile Phe Ala Arg Glu Val Ile Ser Arg Asn Gly Leu Gln Ile Leu
 1               5                  10                  15      
Gly Thr Ile Ile Glu Asp Gly Asp Asp Leu Gly Glu Val Leu Ala Leu
            20                  25                  30          
Ser Leu Arg Ala Phe Ser Glu Leu Met Glu His Gly Val Val Ser Trp
        35                  40                  45              
Glu Thr Leu Ser Ile Pro Phe Val Arg Lys Val Val Cys Tyr Val Asn
    50                  55                  60                  
Met Asn Leu Met Asp Ala Ser Val Pro Pro Leu Ala Leu Gly Leu Leu
65                  70                  75                  80  
Glu Ser Val Thr Leu Ser Ser Pro Ala Leu Gly Gln Leu Val Lys Ser
                85                  90                  95      
Glu Val Pro Leu Asp Arg Leu Leu Val His Leu Gln Val Met Asn Gln
            100                 105                 110         
Gln Leu Gln Thr Lys Ala Met Ala Leu Leu Thr Ala Leu Leu Gln Gly
        115                 120                 125             
Ala Ser Pro Val Glu Arg Lys His Met Leu Asp Tyr Leu Trp Gln Arg
    130                 135                 140                 
Asn Leu Arg Gln Phe Ile Tyr Lys Asn Ile Ile His Ser Ala Ala Pro
145                 150                 155                 160 
Met Gly Asp Glu Met Ala His His Leu Tyr Val Leu Gln Ala Leu Met
                165                 170                 175     
Leu Gly Leu Leu Glu Pro Arg Met Arg Thr Pro Leu Asp Pro Tyr Ser
            180                 185                 190         
Gln Glu Gln Arg Glu Gln Leu Gln Val Leu Arg Gln Ala Ala Phe Glu
        195                 200                 205             
Val Glu Gly Glu Ser Ser Gly Ala Gly Leu Ser Ala Asp Arg Arg Arg
    210                 215                 220                 
Ser Leu Cys Ala Arg Glu Phe Arg Lys Leu Gly Phe Ser Asn Ser Asn
225                 230                 235                 240 
Pro Ala Gln Asp Leu Glu Arg Val Pro Pro Gly Leu Leu Ala Leu Asp
                245                 250                 255     
Asn Met Leu Tyr Phe Ser Arg Asn Ala Pro Ser Ala Tyr Ser Arg Phe
            260                 265                 270         
Val Leu Glu Asn Ser Ser Arg Glu Asp Lys His Glu Cys Pro Phe Ala
        275                 280                 285             
Arg Gly Ser Ile Gln Leu Thr Val Leu Leu Cys Glu Leu Leu Arg Val
    290                 295                 300                 
Gly Glu Pro Cys Ser Glu Thr Ala Gln Asp Phe Ser Pro Met Phe Phe
305                 310                 315                 320 
Gly Gln Asp Gln Ser Phe His Glu Leu Phe Cys Val Gly Ile Gln Leu
                325                 330                 335     
Leu Asn Lys Thr Trp Lys Glu Met Arg Ala Thr Gln Glu Asp Phe Asp
            340                 345                 350         
Lys Val Met Gln Val Val Arg Glu Gln Leu Ala Arg Thr Leu Ala Leu
        355                 360                 365             
Lys Pro Thr Ser Leu Glu Leu Phe Arg Thr Lys Val Asn Ala Leu Thr
    370                 375                 380                 
Tyr Gly Glu Val Leu Arg Leu Arg Gln Thr Glu Arg Leu His Gln Glu
385                 390                 395                 400 
Gly Thr Leu Ala Pro Pro Ile Leu Glu Leu Arg Glu Lys Leu Lys Pro
                405                 410                 415     
Glu Leu Met Gly Leu Ile Arg Gln Gln Arg Leu Leu Arg Leu Cys Glu
            420                 425                 430         
Gly Thr Leu Phe Arg Lys Ile Ser Ser Arg Arg Arg Gln Asp Lys Leu
        435                 440                 445             
Trp Phe Cys Cys Leu Ser Pro Asn His Lys Leu Leu Gln Tyr Gly Asp
    450                 455                 460                 
Met Glu Glu Gly Ala Ser Pro Pro Thr Leu Glu Ser Leu Pro Glu Gln
465                 470                 475                 480 
Leu Pro Val Ala Asp Met Arg Ala Leu Leu Thr Gly Lys Asp Cys Pro
                485                 490                 495     
His Val Arg Glu Lys Gly Ser Gly Lys Gln Asn Lys Asp Leu Tyr Glu
            500                 505                 510         
Leu Ala Phe Ser Ile Ser Tyr Asp Arg Gly Glu Glu Glu Ala Tyr Leu
        515                 520                 525             
Asn Phe Ile Ala Pro Ser Lys Arg Glu Phe Tyr Leu Trp Thr Asp Gly
    530                 535                 540                 
Leu Ser Ala Leu Leu Gly Ser Pro Met Gly Ser Glu Gln Thr Arg Leu
545                 550                 555                 560 
Asp Leu Glu Gln Leu Leu Thr Met Glu Thr Lys Leu Arg Leu Leu Glu
                565                 570                 575     
Leu Glu Asn Val Pro Ile Pro Glu Arg Pro Pro Pro Val Pro Pro Pro
            580                 585                 590         
Pro Thr Asn Phe Asn Phe Cys Tyr Asp Cys Ser Ile Ala Glu Pro
        595                 600                 605         


<210> 1515
<211> 321
<212> PRT
<213> Homo sapiens

<400> 1515
Met Ala Ala Asp Val Thr Gly Lys Ser Asp Pro Phe Cys Val Val Glu
 1               5                  10                  15      
Leu Asn Asn Asp Arg Leu Leu Thr His Thr Val Tyr Lys Asn Leu Asn
            20                  25                  30          
Pro Glu Trp Asn Lys Val Phe Thr Phe Asn Ile Lys Asp Ile His Ser
        35                  40                  45              
Val Leu Glu Val Thr Val Tyr Asp Glu Asp Arg Asp Arg Ser Ala Asp
    50                  55                  60                  
Phe Leu Gly Lys Val Ala Ile Pro Leu Leu Ser Ile Gln Asn Gly Glu
65                  70                  75                  80  
Gln Lys Ala Tyr Val Leu Lys Asn Arg Gln Leu Thr Gly Pro Thr Lys
                85                  90                  95      
Gly Val Ile Tyr Leu Glu Ile Asp Val Ile Phe Asn Ala Val Lys Ala
            100                 105                 110         
Ser Leu Arg Thr Leu Ile Pro Lys Glu Gln Lys Tyr Ile Glu Glu Glu
        115                 120                 125             
Asn Arg Leu Ser Lys Gln Leu Leu Leu Arg Asn Phe Ile Arg Met Lys
    130                 135                 140                 
Arg Cys Val Met Val Leu Val Asn Ala Ala Tyr Tyr Val Asn Ser Cys
145                 150                 155                 160 
Phe Asp Trp Asp Ser Pro Pro Arg Ser Leu Ala Ala Phe Val Val Val
                165                 170                 175     
Glu Asp Met Leu Glu Asp Glu Glu Glu Glu Asp Asp Lys Asp Asp Lys
            180                 185                 190         
Asp Ser Glu Lys Lys Gly Phe Ile Asn Lys Ile Tyr Ala Ile Gln Glu
        195                 200                 205             
Val Cys Val Ser Val Gln Asn Ile Leu Asp Glu Val Ala Ser Phe Gly
    210                 215                 220                 
Glu Arg Ile Lys Ser Thr Phe Asn Trp Thr Val Pro Phe Leu Ser Trp
225                 230                 235                 240 
Leu Ala Ile Val Ala Leu Cys Val Phe Thr Ala Ile Leu Tyr Cys Ile
                245                 250                 255     
Pro Leu Arg Tyr Ile Val Leu Val Trp Gly Ile Asn Lys Phe Thr Lys
            260                 265                 270         
Lys Leu Arg Ser Pro Tyr Ala Ile Asp Asn Asn Glu Leu Leu Asp Phe
        275                 280                 285             
Leu Ser Arg Val Pro Ser Asp Val Gln Val Val Gln Tyr Gln Glu Leu
    290                 295                 300                 
Lys Pro Asp Pro Ser His Ser Pro Tyr Lys Arg Lys Lys Asn Asn Leu
305                 310                 315                 320 
Gly
    


<210> 1516
<211> 363
<212> PRT
<213> Homo sapiens

<400> 1516
Met Arg Gln Glu Leu Lys Asn Leu Lys Leu Ala Val Asp Arg Glu Arg
 1               5                  10                  15      
Glu Arg Pro Val Lys Ala Gly Lys Lys Lys Asp Lys Lys Gly Lys Lys
            20                  25                  30          
Gly Lys Lys Lys Glu Lys Lys Ala Lys Lys Asp Lys Asp Leu Thr Ala
        35                  40                  45              
Asp Arg Thr Ile Glu Ser Leu Tyr Lys Glu Leu Val Glu Glu Gly Leu
    50                  55                  60                  
Leu Ile Gln Ala Leu Lys Val Asn Leu Ser Asp Tyr Ile Gly Glu Tyr
65                  70                  75                  80  
Ser Tyr Leu Gly Thr Thr Leu Arg Gln Val Ser Ile Glu Pro Met Pro
                85                  90                  95      
Ser Leu Leu Asp Val Arg Gln Leu Ile Thr Leu Tyr Gly Ile Trp Pro
            100                 105                 110         
Leu Gly Ser Ala Ala Val His Glu Lys Ala Pro Leu Val Lys Ser Leu
        115                 120                 125             
Leu Leu Ala Gly Pro Ser Gly Val Gly Lys Lys Met Leu Val His Ala
    130                 135                 140                 
Ile Cys Thr Glu Thr Gly Ala Asn Leu Phe Asn Leu Ser Ser Ser Asn
145                 150                 155                 160 
Ile Ala Gly Lys Tyr Pro Gly Lys Asn Gly Leu Gln Met Met Leu His
                165                 170                 175     
Ala Val Phe Lys Val Ala Arg Gln Leu Gln Pro Ser Val Val Trp Ile
            180                 185                 190         
Glu Asp Thr Glu Lys Thr Phe Tyr Lys Lys Val Pro Asn Ala Glu Lys
        195                 200                 205             
Met Asn Glu Pro Lys Arg Leu Lys Lys His Leu Pro Gln Ile Leu Lys
    210                 215                 220                 
Leu Leu Lys Pro Asp Asp Arg Ile Leu Ile Val Gly Thr Thr Arg Arg
225                 230                 235                 240 
Pro Phe Asp Ala Glu Leu Gln Ser Phe Cys Lys Val Tyr Gln Lys Ile
                245                 250                 255     
Ile Leu Val Pro Arg Pro Asp Tyr Ala Ser Arg Tyr Val Leu Trp Lys
            260                 265                 270         
Gln Ile Ile Glu Arg Asn Gly Gly Val Leu Thr Ser Ala Leu Asn Val
        275                 280                 285             
Ser Cys Leu Ala Lys Val Thr Asp Gly Phe Thr Gln Gly His Ile Val
    290                 295                 300                 
Glu Val Val Lys Gly Val Leu Thr Asp Gln Arg Ile Arg Arg Gln Ile
305                 310                 315                 320 
His Lys Pro Leu Thr Ala Val Glu Phe Ile Thr Ala Ile Thr Ser Met
                325                 330                 335     
Asn Pro Val Tyr Lys Glu Glu Glu Glu Ser Phe Lys Asn Trp Tyr Ala
            340                 345                 350         
Lys Thr Pro Leu Gly Lys Asn Val Pro Trp Arg
        355                 360             


<210> 1517
<211> 613
<212> PRT
<213> Homo sapiens

<400> 1517
Met Gly Glu Ala Phe Tyr Thr Val Lys Leu Glu Arg Leu Glu Ser Cys
 1               5                  10                  15      
Asp Thr Ala Gly Leu Ser Phe Gln Glu Val Gln Lys Asn Thr Tyr Asp
            20                  25                  30          
Phe Glu Cys Gln Trp Lys Asp Asp Glu Gly Asn Tyr Lys Thr Val Leu
        35                  40                  45              
Met Leu Gln Lys Glu Asn Leu Pro Gly Arg Arg Ala Gln Arg Asp Arg
    50                  55                  60                  
Arg Ala Ala Gly Asn Arg His Ile Glu Asn Gln Leu Gly Val Ser Phe
65                  70                  75                  80  
Gln Ser His Leu Pro Glu Leu Gln Gln Phe Gln Arg Glu Gly Lys Ile
                85                  90                  95      
Tyr Glu Tyr Asn Gln Val Glu Lys Ser Pro Asn Asn Arg Gly Lys His
            100                 105                 110         
Tyr Lys Cys Asp Glu Cys Gly Lys Val Phe Ser Gln Asn Ser Arg Leu
        115                 120                 125             
Thr Ser His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Gln Cys Asn
    130                 135                 140                 
Lys Cys Gly Lys Ala Phe Thr Val Arg Ser Asn Leu Thr Ile His Gln
145                 150                 155                 160 
Val Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys
                165                 170                 175     
Val Phe Ser Gln Pro Ser Asn Leu Ala Gly His Gln Arg Ile His Thr
            180                 185                 190         
Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Ala Phe Arg Ala
        195                 200                 205             
His Ser Lys Leu Thr Thr His Gln Val Ile His Thr Gly Glu Lys Pro
    210                 215                 220                 
Tyr Lys Cys Lys Glu Cys Gly Lys Cys Phe Thr Gln Asn Ser His Leu
225                 230                 235                 240 
Ala Ser His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asn
                245                 250                 255     
Glu Cys Gly Lys Ala Phe Ser Val Arg Ser Ser Leu Thr Thr His Gln
            260                 265                 270         
Thr Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys
        275                 280                 285             
Val Phe Arg His Asn Ser Tyr Leu Ala Lys His Arg Arg Ile His Thr
    290                 295                 300                 
Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Ala Phe Ser Met
305                 310                 315                 320 
His Ser Asn Leu Thr Lys His Gln Ile Ile His Thr Gly Glu Lys Pro
                325                 330                 335     
Phe Lys Cys Asn Glu Cys Val Lys Val Phe Thr Gln Tyr Ser His Leu
            340                 345                 350         
Ala Asn His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Arg Cys Asp
        355                 360                 365             
Glu Cys Gly Lys Ala Phe Ser Val Arg Ser Ser Leu Thr Thr His Gln
    370                 375                 380                 
Ala Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Asp Cys Gly Lys
385                 390                 395                 400 
Val Phe Thr Gln Asn Ser His Leu Ala Ser His Arg Gly Ile His Ser
                405                 410                 415     
Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Ala Phe Ser Gln
            420                 425                 430         
Thr Ser Gln Leu Ala Arg His Trp Arg Val His Thr Gly Glu Lys Pro
        435                 440                 445             
Tyr Lys Cys Asn Glu Cys Gly Lys Ala Phe Ser Val His Ser Ser Leu
    450                 455                 460                 
Thr Ile His Gln Thr Ile His Thr Gly Gln Lys Pro Tyr Lys Cys Asn
465                 470                 475                 480 
Asp Cys Gly Lys Val Phe Arg His Asn Ser Tyr Leu Ala Ile His Gln
                485                 490                 495     
Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys
            500                 505                 510         
Ala Phe Ser Val His Ser Asn Leu Ala Thr His Gln Val Ile His Thr
        515                 520                 525             
Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Val Phe Thr Gln
    530                 535                 540                 
Asn Ser His Leu Ala Asn His Arg Arg Ile His Thr Gly Glu Lys Pro
545                 550                 555                 560 
Tyr Arg Cys Asn Glu Cys Gly Lys Ala Phe Ser Val Arg Ser Thr Leu
                565                 570                 575     
Thr Thr His Met Ala Ile His Thr Gly Asp Lys Pro Tyr Lys Cys Asn
            580                 585                 590         
Gln Cys Gly Lys Val Phe Thr Gln Asn Ser Asn Leu Ala Lys His Arg
        595                 600                 605             
Arg Ile His Ser Gly
    610             


<210> 1518
<211> 825
<212> PRT
<213> Homo sapiens

<400> 1518
Met Ala Ala Asp Glu Gly Ser Ala Glu Lys Gln Ala Gly Glu Ala His
 1               5                  10                  15      
Met Ala Ala Asp Gly Glu Thr Asn Gly Ser Cys Glu Asn Ser Asp Ala
            20                  25                  30          
Ser Ser His Ala Asn Ala Ala Lys His Thr Gln Asp Ser Ala Arg Val
        35                  40                  45              
Asn Pro Gln Asp Gly Thr Asn Thr Leu Thr Arg Ile Ala Glu Asn Gly
    50                  55                  60                  
Val Ser Glu Arg Asp Ser Glu Ala Ala Lys Gln Asn His Val Thr Ala
65                  70                  75                  80  
Asp Asp Phe Val Gln Thr Ser Val Ile Gly Ser Asn Gly Tyr Ile Leu
                85                  90                  95      
Asn Lys Pro Ala Leu Gln Ala Gln Pro Leu Arg Thr Thr Ser Thr Leu
            100                 105                 110         
Ala Ser Ser Leu Pro Gly His Ala Ala Lys Thr Leu Pro Gly Gly Ala
        115                 120                 125             
Gly Lys Gly Arg Thr Pro Ser Ala Phe Pro Gln Thr Pro Ala Ala Pro
    130                 135                 140                 
Pro Ala Thr Leu Gly Glu Gly Ser Ala Asp Thr Glu Asp Arg Lys Leu
145                 150                 155                 160 
Pro Ala Pro Gly Ala Asp Val Lys Val His Arg Ala Arg Lys Thr Met
                165                 170                 175     
Pro Lys Ser Val Val Gly Leu His Ala Ala Ser Lys Asp Pro Arg Glu
            180                 185                 190         
Val Arg Glu Ala Arg Asp His Lys Glu Pro Lys Glu Glu Ile Asn Lys
        195                 200                 205             
Asn Ile Ser Asp Phe Gly Arg Gln Gln Leu Leu Pro Pro Phe Pro Ser
    210                 215                 220                 
Leu His Gln Ser Leu Pro Gln Asn Gln Cys Tyr Met Ala Thr Thr Lys
225                 230                 235                 240 
Ser Gln Thr Ala Cys Leu Pro Phe Val Leu Ala Ala Ala Val Ser Arg
                245                 250                 255     
Lys Lys Lys Arg Arg Met Gly Thr Tyr Ser Leu Val Pro Lys Lys Lys
            260                 265                 270         
Thr Lys Val Leu Lys Gln Arg Thr Val Ile Glu Met Phe Lys Ser Ile
        275                 280                 285             
Thr His Ser Thr Val Gly Ser Lys Gly Glu Lys Asp Leu Gly Ala Ser
    290                 295                 300                 
Ser Leu His Val Asn Gly Glu Ser Leu Glu Met Asp Ser Asp Glu Asp
305                 310                 315                 320 
Asp Ser Glu Glu Leu Glu Glu Asp Asp Gly His Gly Ala Glu Gln Ala
                325                 330                 335     
Ala Ala Phe Pro Thr Glu Asp Ser Arg Thr Ser Lys Glu Ser Met Ser
            340                 345                 350         
Glu Ala Asp Arg Ala Gln Lys Met Asp Gly Glu Ser Glu Glu Glu Gln
        355                 360                 365             
Glu Ser Val Asp Thr Gly Glu Glu Glu Glu Gly Gly Asp Glu Ser Asp
    370                 375                 380                 
Leu Ser Ser Glu Ser Ser Ile Lys Lys Lys Phe Leu Lys Arg Lys Gly
385                 390                 395                 400 
Lys Thr Asp Ser Pro Trp Ile Lys Pro Ala Arg Lys Arg Arg Arg Arg
                405                 410                 415     
Ser Arg Lys Lys Pro Ser Gly Ala Leu Gly Ser Glu Ser Tyr Lys Ser
            420                 425                 430         
Ser Ala Gly Ser Ala Glu Gln Thr Ala Pro Gly Asp Ser Thr Gly Tyr
        435                 440                 445             
Met Glu Val Ser Leu Asp Ser Leu Asp Leu Arg Val Lys Gly Ile Leu
    450                 455                 460                 
Ser Ser Gln Ala Glu Gly Leu Ala Asn Gly Pro Asp Val Leu Glu Thr
465                 470                 475                 480 
Asp Gly Leu Gln Glu Val Pro Leu Cys Ser Cys Arg Met Glu Thr Pro
                485                 490                 495     
Lys Ser Arg Glu Ile Thr Thr Leu Ala Asn Asn Gln Cys Met Ala Thr
            500                 505                 510         
Glu Ser Val Asp His Glu Leu Gly Arg Cys Thr Asn Ser Val Val Lys
        515                 520                 525             
Tyr Gly Leu Met Arg Pro Ser Asn Lys Ala Pro Leu Leu Val Leu Cys
    530                 535                 540                 
Glu Asp His Arg Gly Arg Met Val Lys His Gln Cys Cys Pro Gly Cys
545                 550                 555                 560 
Gly Tyr Phe Cys Thr Ala Gly Asn Phe Met Glu Cys Gln Pro Glu Ser
                565                 570                 575     
Ser Ile Ser His Arg Phe His Lys Asp Cys Ala Ser Arg Val Asn Asn
            580                 585                 590         
Ala Ser Tyr Cys Pro His Cys Gly Glu Glu Ser Ser Lys Ala Lys Glu
        595                 600                 605             
Val Thr Ile Ala Lys Ala Asp Thr Thr Ser Thr Val Thr Pro Val Pro
    610                 615                 620                 
Gly Gln Glu Lys Gly Ser Ala Leu Glu Gly Arg Ala Asp Thr Thr Thr
625                 630                 635                 640 
Gly Ser Ala Ala Gly Pro Pro Leu Ser Glu Asp Asp Lys Leu Gln Gly
                645                 650                 655     
Ala Ala Ser His Val Pro Glu Gly Phe Asp Pro Thr Gly Pro Ala Gly
            660                 665                 670         
Leu Gly Arg Pro Thr Pro Gly Leu Ser Gln Gly Pro Gly Lys Glu Thr
        675                 680                 685             
Leu Glu Ser Ala Leu Ile Ala Leu Asp Ser Glu Lys Pro Lys Lys Leu
    690                 695                 700                 
Arg Phe His Pro Lys Gln Leu Tyr Phe Ser Ala Arg Gln Gly Glu Leu
705                 710                 715                 720 
Gln Lys Val Leu Leu Met Leu Val Asp Gly Ile Asp Pro Asn Phe Lys
                725                 730                 735     
Met Glu His Gln Asn Lys Arg Ser Pro Leu His Ala Ala Ala Glu Ala
            740                 745                 750         
Gly His Val Asp Ile Cys His Met Leu Val Gln Ala Gly Ala Asn Ile
        755                 760                 765             
Asp Thr Cys Ser Glu Asp Gln Arg Thr Pro Leu Met Glu Ala Ala Glu
    770                 775                 780                 
Asn Asn His Leu Glu Ala Val Lys Tyr Leu Ile Lys Ala Gly Ala Leu
785                 790                 795                 800 
Val Asp Pro Lys Ile Gln Lys Thr Ser Lys Val Tyr Thr Glu Ser Gln
                805                 810                 815     
Glu Thr Gln Arg Ser Gln Thr Ile Leu
            820                 825 


<210> 1519
<211> 507
<212> PRT
<213> Homo sapiens

<400> 1519
Met Lys His Lys Arg Lys Asn Leu Gln Pro Phe Phe Ile Val Leu Trp
 1               5                  10                  15      
Asn Gly Gly Asp Leu Leu Met Ile Ile Ser Lys Lys Arg Trp Ser Trp
            20                  25                  30          
Gly Gly Ser Ala Met Ala Asn Ser Glu Ser Lys Thr Ala Asn Lys Arg
        35                  40                  45              
Ser Ala Ser Thr Glu Lys Leu Glu Gln Gly Thr Ser Ala Leu Ile Arg
    50                  55                  60                  
Gln Met Pro Leu Ser Ser Ala Gly Leu Gln Asn Ser Val Ala Lys Arg
65                  70                  75                  80  
Lys Thr Asp Lys Glu Arg Ser Ser Ser Leu Asn Arg Arg Asp Ser Asn
                85                  90                  95      
Leu His Ser Ser Thr Asp Lys Glu Gln Ala Glu Arg Lys Pro Arg Val
            100                 105                 110         
Thr Gly Val Thr Asn Tyr Val Met Gln Tyr Val Thr Val Pro Leu Arg
        115                 120                 125             
Lys Cys Thr Ser Asp Glu Leu Arg Ala Val Met Phe Pro Met Ser Thr
    130                 135                 140                 
Met Lys Ile Pro Pro Gln Thr Lys Val Glu Glu Ser Pro Leu Glu Lys
145                 150                 155                 160 
Val Glu Thr Pro Pro Lys Ala Ser Val Asp Ala Pro Pro Gln Val Asn
                165                 170                 175     
Val Glu Val Phe Cys Asn Thr Ser Met Glu Ala Ser Pro Lys Ala Gly
            180                 185                 190         
Val Gly Met Ala Pro Glu Val Ser Thr Asp Ser Phe Pro Val Val Ser
        195                 200                 205             
Val Asp Val Ser Pro Val Val Ser Thr Tyr Asp Ser Glu Met Ser Met
    210                 215                 220                 
Asp Ala Ser Pro Glu Leu Ser Ile Glu Ala Leu Pro Lys Val Asp Leu
225                 230                 235                 240 
Glu Thr Val Pro Lys Val Ser Ile Val Ala Ser Pro Glu Ala Ser Leu
                245                 250                 255     
Glu Ala Pro Pro Glu Val Ser Leu Glu Ala Leu Pro Glu Val Ser Val
            260                 265                 270         
Glu Ala Ala Pro Glu Gly Ser Leu Glu Ala Pro Pro Lys Gly Ser Ala
        275                 280                 285             
Glu Val Ala Pro Lys Glu Ser Val Lys Gly Ser Pro Lys Glu Ser Met
    290                 295                 300                 
Glu Ala Ser Pro Glu Ala Met Val Lys Ala Ser Pro Lys Thr Ser Leu
305                 310                 315                 320 
Glu Ala Ser Met Glu Ala Ser Pro Lys Ala Lys Ala Arg Asp Ala Pro
                325                 330                 335     
Lys Lys Ser Glu Met Asp Lys Gln Ala Leu Ile Pro Ile Ala Lys Lys
            340                 345                 350         
Arg Leu Ser Ser Tyr Thr Glu Cys Tyr Lys Trp Ser Ser Ser Pro Glu
        355                 360                 365             
Asn Ala Cys Gly Leu Pro Ser Pro Ile Ser Thr Asn Arg Gln Ile Gln
    370                 375                 380                 
Lys Asn Cys Pro Pro Ser Pro Leu Pro Leu Ile Ser Lys Gln Ser Pro
385                 390                 395                 400 
Gln Thr Ser Phe Pro Tyr Lys Ile Met Pro Ile Gln His Thr Leu Ser
                405                 410                 415     
Val Gln Ser Ala Ser Ser Thr Val Lys Lys Lys Lys Glu Thr Val Ser
            420                 425                 430         
Lys Thr Thr Asn Arg Cys Glu Ala Leu Ser Gln Arg His Met Ile Tyr
        435                 440                 445             
Glu Glu Ser Gly Asn Lys Ser Thr Ala Gly Ile Met Asn Ala Glu Ala
    450                 455                 460                 
Ala Thr Lys Ile Leu Thr Glu Leu Arg Arg Leu Ala Asp Asp Gly Gly
465                 470                 475                 480 
Arg Arg Arg Ser Trp Arg Trp Arg Gln Pro Ile Leu Glu Arg Ala Ala
                485                 490                 495     
Gly Thr Asp Gly Cys Cys Ser Lys Arg Asp Cys
            500                 505         


<210> 1520
<211> 325
<212> PRT
<213> Homo sapiens

<400> 1520
Met Lys Gly Phe Leu Asp Phe Ile Leu Ser Asn Ser Pro Asp Ala Gln
 1               5                  10                  15      
Leu Leu Arg Asp Ile Phe Val Phe Lys Val Leu Pro Met Leu Asn Pro
            20                  25                  30          
Asp Gly Val Ile Val Gly Asn Tyr Arg Cys Ser Leu Ala Gly Arg Asp
        35                  40                  45              
Leu Asn Arg His Tyr Lys Thr Ile Leu Lys Glu Ser Phe Pro Cys Ile
    50                  55                  60                  
Trp Tyr Thr Arg Asn Met Ile Lys Arg Leu Leu Glu Glu Arg Glu Val
65                  70                  75                  80  
Leu Leu Tyr Cys Asp Phe His Gly His Ser Arg Lys Asn Asn Ile Phe
                85                  90                  95      
Leu Tyr Gly Cys Asn Asn Asn Asn Arg Lys Tyr Trp Leu His Glu Arg
            100                 105                 110         
Val Phe Pro Leu Met Leu Cys Lys Asn Ala Pro Asp Lys Phe Ser Phe
        115                 120                 125             
His Ser Cys Asn Phe Lys Val Gln Lys Cys Lys Glu Gly Thr Gly Arg
    130                 135                 140                 
Val Val Met Trp Arg Met Gly Ile Leu Asn Ser Tyr Thr Met Glu Ser
145                 150                 155                 160 
Thr Phe Gly Gly Ser Thr Leu Gly Asn Lys Arg Asp Thr His Phe Thr
                165                 170                 175     
Ile Glu Asp Leu Lys Ser Leu Gly Tyr His Val Cys Asp Thr Leu Leu
            180                 185                 190         
Asp Phe Cys Asp Pro Asp Gln Ile Lys Phe Thr Gln Cys Leu Ala Glu
        195                 200                 205             
Leu Lys Glu Leu Leu Arg Gln Glu Ile His Lys Lys Phe His Glu Leu
    210                 215                 220                 
Gly Gln Asp Val Asp Leu Glu Gly Ser Trp Ser Asp Ile Ser Leu Ser
225                 230                 235                 240 
Asp Ile Glu Ser Ser Thr Ser Gly Ser Asp Ser Ser Leu Ser Asp Gly
                245                 250                 255     
Leu Pro Val His Leu Ala Asn Ile Ala Asp Glu Leu Thr Gln Lys Lys
            260                 265                 270         
Lys Met Phe Lys Lys Lys Lys Lys Lys Ser Leu Gln Thr Arg Lys Gln
        275                 280                 285             
Arg Asn Glu Gln Tyr Gln Lys Lys Asn Leu Met Gln Lys Leu Lys Leu
    290                 295                 300                 
Thr Glu Asp Thr Ser Glu Lys Ala Gly Phe Ala Ser Thr Leu Gln Lys
305                 310                 315                 320 
Gln Pro Thr Phe Phe
                325 


<210> 1521
<211> 801
<212> PRT
<213> Homo sapiens

<400> 1521
Met Lys Ala Phe Arg Gln Pro Ala Ser Asp Ala Leu Lys Asn Gly Val
 1               5                  10                  15      
Lys Lys Ser Ser Asp Lys Gln Lys Asp Leu Asn Glu Lys Cys Leu Tyr
            20                  25                  30          
Glu Val Gly Arg Asp Asp Asn Ser Lys Lys Ile Met Glu Asn Ser Gly
        35                  40                  45              
Ile Gln Met Val Ser Lys Asn Gly Asn Leu Gln Leu His Thr Asp Lys
    50                  55                  60                  
Gly Ser Phe Leu Lys Glu Lys Asp Lys Lys Leu Lys Lys Lys Asn Lys
65                  70                  75                  80  
Lys Thr Leu Asp Thr Gly Ala Ile Pro Gly Lys Asn Arg Glu Gly Asn
                85                  90                  95      
Thr Gln Lys Lys Glu Thr Thr Phe Phe Leu Lys Glu Lys Gln Tyr Gln
            100                 105                 110         
Asn Arg Met Ser Leu Arg Gln Arg Lys Thr Glu Phe Phe Lys Ser Ser
        115                 120                 125             
Thr Leu Phe Asn Asn Glu Ser Leu Val Tyr Glu Asp Ile Ala Asn Asp
    130                 135                 140                 
Asp Leu Leu Lys Val Ser Ser Leu Cys Asn Asn Asn Lys Leu Ser Arg
145                 150                 155                 160 
Lys Thr Ser Ile Pro Val Lys Asp Ile Lys Leu Thr Gln Ser Lys Ala
                165                 170                 175     
Glu Ser Glu Ala Ser Leu Leu Asn Val Ser Thr Pro Lys Ser Thr Arg
            180                 185                 190         
Arg Ser Gly Arg Ile Ser Ser Thr Pro Thr Thr Glu Thr Ile Arg Gly
        195                 200                 205             
Ile Asp Ser Asp Asp Val Gln Asp Asn Ser Gln Leu Lys Ala Ser Thr
    210                 215                 220                 
Gln Lys Ala Ala Asn Leu Ser Glu Lys His Ser Leu Tyr Thr Ala Glu
225                 230                 235                 240 
Leu Ile Thr Val Pro Phe Asp Ser Glu Ser Pro Ile Arg Met Lys Phe
                245                 250                 255     
Thr Arg Ile Ser Thr Pro Lys Lys Ser Lys Lys Lys Ser Asn Lys Arg
            260                 265                 270         
Ser Glu Lys Ser Glu Ala Thr Asp Gly Gly Phe Thr Ser Gln Ile Arg
        275                 280                 285             
Lys Ala Ser Asn Thr Ser Lys Asn Ile Ser Lys Ala Lys Gln Leu Ile
    290                 295                 300                 
Glu Lys Ala Lys Ala Leu His Ile Ser Arg Ser Lys Val Thr Glu Glu
305                 310                 315                 320 
Ile Ala Ile Pro Leu Arg Arg Ser Ser Arg His Gln Thr Leu Pro Glu
                325                 330                 335     
Arg Lys Lys Leu Ser Glu Thr Glu Asp Ser Val Ile Ile Ile Asp Ser
            340                 345                 350         
Ser Pro Thr Ala Leu Lys His Pro Glu Lys Asn Gln Lys Lys Leu Gln
        355                 360                 365             
Cys Leu Asn Asp Val Leu Gly Lys Lys Leu Asn Thr Ser Thr Lys Asn
    370                 375                 380                 
Val Pro Gly Lys Met Lys Val Ala Pro Leu Phe Leu Val Arg Lys Ala
385                 390                 395                 400 
Gln Lys Ala Ala Asp Pro Val Pro Ser Phe Asp Glu Ser Ser Gln Asp
                405                 410                 415     
Thr Ser Glu Lys Ser Gln Asp Cys Asp Val Gln Cys Lys Ala Lys Arg
            420                 425                 430         
Asp Phe Leu Met Ser Gly Leu Pro Asp Leu Leu Lys Arg Gln Ile Ala
        435                 440                 445             
Lys Lys Ala Ala Ala Leu Asp Val Tyr Asn Ala Val Ser Thr Ser Phe
    450                 455                 460                 
Gln Arg Val Val His Val Gln Gln Lys Asp Asp Gly Cys Cys Leu Trp
465                 470                 475                 480 
His Leu Lys Pro Pro Ser Cys Pro Leu Leu Thr Lys Phe Lys Glu Leu
                485                 490                 495     
Asn Thr Lys Val Ile Asp Leu Ser Lys Cys Gly Ile Ala Leu Gly Glu
            500                 505                 510         
Phe Ser Thr Leu Asn Ser Lys Leu Lys Ser Gly Asn Ser Ala Ala Val
        515                 520                 525             
Phe Met Arg Thr Arg Lys Glu Phe Thr Glu Glu Val Arg Asn Leu Leu
    530                 535                 540                 
Leu Glu Glu Ile Arg Trp Ser Asn Pro Glu Phe Ser Leu Lys Lys Tyr
545                 550                 555                 560 
Phe Pro Leu Leu Leu Lys Lys Gln Ile Glu His Gln Val Leu Ser Ser
                565                 570                 575     
Glu Cys His Ser Lys Gln Glu Leu Glu Ala Asp Val Ser His Lys Glu
            580                 585                 590         
Thr Lys Arg Lys Leu Val Glu Ala Glu Asn Ser Lys Ser Lys Arg Lys
        595                 600                 605             
Lys Pro Asn Glu Tyr Ser Lys Asn Leu Glu Lys Thr Asn Arg Lys Ser
    610                 615                 620                 
Glu Glu Leu Ser Lys Arg Asn Asn Ser Ser Gly Ile Lys Leu Asp Ser
625                 630                 635                 640 
Ser Lys Asp Ser Gly Thr Glu Asp Met Leu Trp Thr Glu Lys Tyr Gln
                645                 650                 655     
Pro Gln Thr Ala Ser Glu Leu Ile Gly Asn Glu Leu Ala Ile Lys Lys
            660                 665                 670         
Leu His Ser Trp Leu Lys Asp Trp Lys Arg Arg Ala Glu Leu Glu Glu
        675                 680                 685             
Arg Gln Asn Leu Lys Gly Lys Arg Asp Glu Lys His Glu Asp Phe Ser
    690                 695                 700                 
Gly Gly Ile Asp Phe Lys Gly Ser Ser Asp Asp Glu Glu Glu Ser Arg
705                 710                 715                 720 
Leu Cys Asn Thr Val Leu Ile Thr Gly Pro Thr Gly Val Gly Lys Thr
                725                 730                 735     
Ala Ala Val Tyr Ala Cys Ala Gln Glu Leu Gly Phe Lys Ile Phe Glu
            740                 745                 750         
Val Asn Ala Ser Ser Gln Arg Ser Gly Arg Gln Ile Leu Ser Gln Leu
        755                 760                 765             
Lys Glu Ala Thr Gln Ser His Gln Val Asp Lys Gln Gly Val Asn Ser
    770                 775                 780                 
Gln Lys Pro Cys Phe Phe Asn Ser Tyr Tyr Ile Gly Lys Ser Pro Ser
785                 790                 795                 800 
Lys
    


<210> 1522
<211> 463
<212> PRT
<213> Homo sapiens

<400> 1522
Met Val Pro Ala Leu Arg Tyr Leu Val Gly Ala Cys Gly Arg Ala Arg
 1               5                  10                  15      
Gly Leu Phe Ala Gly Gly Ser Pro Gly Ala Cys Gly Phe Ala Ser Gly
            20                  25                  30          
Arg Pro Arg Pro Leu Cys Gly Gly Ser Arg Ser Ala Ser Thr Ser Ser
        35                  40                  45              
Phe Asp Ile Val Ile Val Gly Gly Gly Ile Val Gly Leu Ala Ser Ala
    50                  55                  60                  
Arg Ala Leu Ile Leu Arg His Pro Ser Leu Ser Ile Gly Val Leu Glu
65                  70                  75                  80  
Lys Glu Lys Asp Leu Ala Val His Gln Thr Gly His Asn Ser Gly Val
                85                  90                  95      
Ile His Ser Gly Ile Tyr Tyr Lys Pro Glu Ser Leu Lys Ala Lys Leu
            100                 105                 110         
Cys Val Gln Gly Ala Ala Leu Leu Tyr Glu Tyr Cys Gln Gln Lys Gly
        115                 120                 125             
Ile Ser Tyr Lys Gln Cys Gly Lys Leu Ile Val Ala Val Glu Gln Glu
    130                 135                 140                 
Glu Ile Pro Arg Leu Gln Ala Leu Tyr Glu Lys Gly Leu Gln Asn Gly
145                 150                 155                 160 
Val Pro Gly Leu Arg Leu Ile Gln Gln Glu Asp Ile Lys Lys Lys Glu
                165                 170                 175     
Pro Tyr Cys Arg Gly Leu Met Ala Ile Asp Cys Pro His Thr Gly Ile
            180                 185                 190         
Val Asp Tyr Arg Gln Val Ala Leu Ser Phe Ala Gln Asp Phe Gln Glu
        195                 200                 205             
Ala Gly Gly Ser Val Leu Thr Asn Phe Glu Val Lys Gly Ile Glu Met
    210                 215                 220                 
Ala Lys Glu Ser Pro Ser Arg Ser Ile Asp Gly Met Gln Tyr Pro Ile
225                 230                 235                 240 
Val Ile Lys Asn Thr Lys Gly Glu Glu Ile Arg Cys Gln Tyr Val Val
                245                 250                 255     
Thr Cys Ala Gly Leu Tyr Ser Asp Arg Ile Ser Glu Leu Ser Gly Cys
            260                 265                 270         
Thr Pro Asp Pro Arg Ile Val Pro Phe Arg Gly Asp Tyr Leu Leu Leu
        275                 280                 285             
Lys Pro Glu Lys Cys Tyr Leu Val Lys Gly Asn Ile Tyr Pro Val Pro
    290                 295                 300                 
Asp Ser Arg Phe Pro Phe Leu Gly Val His Phe Thr Pro Arg Met Asp
305                 310                 315                 320 
Gly Ser Ile Trp Leu Gly Pro Asn Ala Val Leu Ala Phe Lys Arg Glu
                325                 330                 335     
Gly Tyr Arg Pro Phe Asp Phe Ser Ala Thr Asp Val Met Asp Ile Ile
            340                 345                 350         
Ile Asn Ser Gly Leu Ile Lys Leu Ala Ser Gln Asn Phe Ser Tyr Gly
        355                 360                 365             
Val Thr Glu Met Tyr Lys Ala Cys Phe Leu Gly Ala Thr Val Lys Tyr
    370                 375                 380                 
Leu Gln Lys Phe Ile Pro Glu Ile Thr Ile Ser Asp Ile Leu Arg Gly
385                 390                 395                 400 
Pro Ala Gly Val Arg Ala Gln Ala Leu Asp Arg Asp Gly Asn Leu Val
                405                 410                 415     
Glu Asp Phe Val Phe Asp Ala Gly Val Gly Asp Ile Gly Asn Arg Ile
            420                 425                 430         
Leu His Val Arg Asn Ala Pro Ser Pro Ala Ala Thr Ser Ser Ile Ala
        435                 440                 445             
Ile Ser Gly Met Ile Ala Asp Glu Val Gln Gln Arg Phe Glu Leu
    450                 455                 460             


<210> 1523
<211> 228
<212> PRT
<213> Homo sapiens

<400> 1523
Met Val Cys Pro Pro Gly Glu Val Pro Val Phe Trp Pro Ser Pro Leu
 1               5                  10                  15      
Thr Ser Leu Gly Ala Val Ser Ser Cys Glu Thr Pro Leu Ala Phe Ala
            20                  25                  30          
Ser Ile Pro Gly Cys Thr Val Met Thr Asp Leu Lys Asp Ala Lys Ala
        35                  40                  45              
Pro Pro Gly Cys Leu Thr Pro Glu Arg Ile Pro Glu Val His His Ile
    50                  55                  60                  
Ser Gln Asp Pro Leu His Tyr Ser Ile Ala Ser Val Ser Ala Ser Gln
65                  70                  75                  80  
Lys Ile Arg Glu Leu Glu Ser Met Ile Gly Ile Asp Pro Gly Asn Arg
                85                  90                  95      
Gly Ile Gly His Leu Leu Cys Lys Asp Glu Leu Leu Lys Ala Ser Leu
            100                 105                 110         
Ser Leu Ser His Ala Arg Ser Val Leu Ile Thr Thr Gly Phe Pro Thr
        115                 120                 125             
His Phe Asn His Glu Pro Pro Val Glu Thr Asp Gly Pro Pro Gly Ala
    130                 135                 140                 
Val Ala Leu Val Ala Phe Leu Gln Ala Leu Glu Lys Glu Val Ala Ile
145                 150                 155                 160 
Ile Val Asp Gln Arg Ala Trp Asn Leu His Gln Lys Ile Val Glu Asp
                165                 170                 175     
Ala Val Glu Gln Gly Val Leu Lys Thr Gln Ile Pro Ile Leu Thr Tyr
            180                 185                 190         
Gln Gly Gly Ser Val Glu Ala Ala Gln Ala Phe Leu Cys Lys Asn Gly
        195                 200                 205             
Asp Pro Gln Thr Pro Arg Phe Asp His Leu Val Ala Ile Glu Gln Cys
    210                 215                 220                 
Arg Lys Ser Cys
225             


<210> 1524
<211> 487
<212> PRT
<213> Homo sapiens

<400> 1524
Met Gln Glu Phe Ala Arg Arg Tyr Phe Arg Arg Ser Gln Ala Leu Leu
 1               5                  10                  15      
Gly Gln Thr Asp Gly Gly Ala Ala Gly Lys Asp Thr Asp Ser Leu Val
            20                  25                  30          
Gln Tyr Thr Lys Ala Pro Ile Gln Glu Ser Leu Leu Ser Leu Ser Asp
        35                  40                  45              
Asp Val Ser Lys Leu Ala Val Ala Ser Phe Leu Ala Leu Met Arg Phe
    50                  55                  60                  
Met Gly Asp Gln Ser Lys Pro Arg Gly Lys Asp Glu Met Asp Leu Leu
65                  70                  75                  80  
Tyr Glu Leu Leu Lys Leu Cys Gln Gln Glu Lys Leu Arg Asp Glu Ile
                85                  90                  95      
Tyr Cys Gln Val Ile Lys Gln Val Thr Gly His Pro Arg Pro Glu His
            100                 105                 110         
Cys Thr Arg Gly Trp Ser Phe Leu Ser Leu Leu Thr Gly Phe Phe Pro
        115                 120                 125             
Pro Ser Thr Arg Leu Met Pro Tyr Leu Thr Lys Phe Leu Gln Asp Ser
    130                 135                 140                 
Gly Pro Ser Gln Glu Leu Ala Arg Ser Ser Gln Glu His Leu Gln Arg
145                 150                 155                 160 
Thr Val Lys Tyr Gly Gly Arg Arg Arg Met Pro Pro Pro Gly Glu Met
                165                 170                 175     
Lys Ala Phe Leu Lys Gly Gln Ala Ile Arg Leu Leu Leu Ile His Leu
            180                 185                 190         
Pro Gly Gly Val Asp Tyr Arg Thr Asn Ile Gln Thr Phe Thr Val Ala
        195                 200                 205             
Ala Glu Val Gln Glu Glu Leu Cys Arg Gln Met Gly Ile Thr Glu Pro
    210                 215                 220                 
Gln Glu Val Gln Glu Phe Ala Leu Phe Leu Ile Lys Glu Lys Ser Gln
225                 230                 235                 240 
Leu Val Arg Pro Leu Gln Pro Ala Glu Cys Leu Asn Ser Val Val Val
                245                 250                 255     
Asp Gln Asp Val Ser Leu His Ser Arg Arg Leu His Trp Glu Thr Pro
            260                 265                 270         
Leu His Phe Asp Asn Ser Thr Tyr Ile Ser Thr His Tyr Ser Gln Val
        275                 280                 285             
Leu Trp Asp Tyr Leu Gln Gly Lys Leu Pro Val Ser Ala Lys Ala Asp
    290                 295                 300                 
Ala Gln Leu Ala Arg Leu Ala Ala Leu Gln His Leu Ser Lys Ala Asn
305                 310                 315                 320 
Arg Asn Thr Pro Ser Gly Gln Asp Leu Leu Ala Tyr Val Pro Lys Gln
                325                 330                 335     
Leu Gln Arg Gln Val Asn Thr Ala Ser Ile Lys Asn Leu Met Gly Gln
            340                 345                 350         
Glu Leu Arg Arg Leu Glu Gly His Ser Pro Gln Glu Ala Gln Ile Ser
        355                 360                 365             
Phe Ile Glu Ala Met Ser Gln Leu Pro Leu Phe Gly Tyr Thr Val Tyr
    370                 375                 380                 
Gly Val Leu Arg Val Ser Met Gln Ala Leu Ser Gly Pro Thr Leu Leu
385                 390                 395                 400 
Gly Leu Asn Arg Gln His Leu Ile Leu Met Asp Pro Ser Ser Gln Ser
                405                 410                 415     
Leu Tyr Cys Arg Ile Ala Leu Lys Ser Leu Gln Arg Leu His Leu Leu
            420                 425                 430         
Ser Pro Leu Glu Glu Lys Gly Pro Pro Gly Leu Glu Val Asn Tyr Gly
        435                 440                 445             
Ser Ala Asp Asn Pro Gln Thr Ile Trp Phe Glu Leu Pro Gln Ala Gln
    450                 455                 460                 
Glu Leu Leu Tyr Thr Thr Val Phe Leu Ile Asp Ser Ser Ala Ser Cys
465                 470                 475                 480 
Thr Glu Trp Pro Ser Ile Asn
                485         


<210> 1525
<211> 135
<212> PRT
<213> Homo sapiens

<400> 1525
Met Asp Ala Leu Leu Gly Thr Gly Pro Arg Arg Ala Arg Gly Cys Leu
 1               5                  10                  15      
Gly Ala Ala Gly Pro Thr Ser Ser Gly Arg Ala Ala Arg Thr Pro Ala
            20                  25                  30          
Ala Pro Trp Ala Arg Phe Ser Ala Trp Leu Glu Cys Val Cys Val Val
        35                  40                  45              
Thr Phe Asp Leu Glu Leu Gly Gln Ala Leu Glu Val Ser Gly Arg Glu
    50                  55                  60                  
Arg Gly Arg Gly Arg Val Gly Arg Ala Ala Pro Leu Gly Ala Ser Pro
65                  70                  75                  80  
Ala Ser Leu Gly Ala Leu Gly Arg Pro Ala Leu Ser Leu Ala Phe Gly
                85                  90                  95      
Arg Arg Leu Leu Glu Gly Pro Leu Leu Arg Ala Pro Glu Ala Leu Pro
            100                 105                 110         
Arg Pro Arg Arg Glu Gly Glu Leu Leu Gly Val Gly Ser Cys Leu His
        115                 120                 125             
Ile Gly Met Glu His Phe Ala
    130                 135 


<210> 1526
<211> 147
<212> PRT
<213> Homo sapiens

<400> 1526
Met Asn Glu Ser Trp Ala Gly Pro Gly Pro Ala Glu Arg Ala Glu Glu
 1               5                  10                  15      
Ala Val Ser Gly Val Gly Val Glu Ala Lys Thr Gln His Ala Gly Gln
            20                  25                  30          
Gly Ala Gln Pro Gly Gly Met Gly Cys Gly Phe Ser Ser Gly Pro Ile
        35                  40                  45              
Gly Met Ala Leu Gly Leu Gly Leu Val Gly Thr Ala Ala Thr Arg Gly
    50                  55                  60                  
Gly Ser Ser Ala Trp Pro Asp Ser Thr Cys Asn Val Gly Arg Gln Trp
65                  70                  75                  80  
Ala Pro Pro Gly Gly Arg Asn Thr Val Arg Ser Met Gln Arg Ala Gly
                85                  90                  95      
Asp His Gly Ala Cys Asp Leu Arg Ala His Pro Gly Gln Thr Trp Val
            100                 105                 110         
Arg Gly Gly Leu Gly Arg Gln Asp Gly Glu Gly Leu Gln Gly Val Phe
        115                 120                 125             
Val Leu Cys Pro Tyr Thr Gly Asp Leu His Gly Arg Val Arg Ser Ile
    130                 135                 140                 
Arg Met Leu
145         


<210> 1527
<211> 377
<212> PRT
<213> Homo sapiens

<400> 1527
Met Asp Pro Ala Ala Arg Val Val Arg Ala Leu Trp Pro Gly Gly Cys
 1               5                  10                  15      
Ala Leu Ala Trp Arg Leu Gly Gly Arg Pro Gln Pro Leu Leu Pro Thr
            20                  25                  30          
Gln Ser Arg Ala Gly Phe Ala Gly Ala Ala Gly Gly Pro Ser Pro Val
        35                  40                  45              
Ala Ala Ala Arg Lys Gly Ser Pro Arg Leu Leu Gly Ala Ala Ala Leu
    50                  55                  60                  
Ala Leu Gly Gly Ala Leu Gly Leu Tyr His Thr Ala Arg Trp His Leu
65                  70                  75                  80  
Arg Ala Gln Asp Leu His Ala Glu Arg Ser Ala Ala Gln Leu Ser Leu
                85                  90                  95      
Ser Ser Arg Leu Gln Leu Thr Leu Tyr Gln Tyr Lys Thr Cys Pro Phe
            100                 105                 110         
Cys Ser Lys Val Arg Ala Phe Leu Asp Phe His Ala Leu Pro Tyr Gln
        115                 120                 125             
Val Val Glu Val Asn Pro Val Arg Arg Ala Glu Ile Lys Phe Ser Ser
    130                 135                 140                 
Tyr Arg Lys Val Pro Ile Leu Val Ala Gln Glu Gly Glu Ser Ser Gln
145                 150                 155                 160 
Gln Leu Asn Asp Ser Ser Val Ile Ile Ser Ala Leu Lys Thr Tyr Leu
                165                 170                 175     
Val Ser Gly Gln Pro Leu Glu Glu Ile Ile Thr Tyr Tyr Pro Ala Met
            180                 185                 190         
Lys Ala Val Asn Glu Gln Gly Lys Glu Val Thr Glu Phe Gly Asn Lys
        195                 200                 205             
Tyr Trp Leu Met Leu Asn Glu Lys Glu Ala Gln Gln Val Tyr Gly Gly
    210                 215                 220                 
Lys Glu Ala Arg Thr Glu Glu Met Lys Trp Arg Gln Trp Ala Asp Asp
225                 230                 235                 240 
Trp Leu Val His Leu Ile Ser Pro Asn Val Tyr Arg Thr Pro Thr Glu
                245                 250                 255     
Ala Leu Ala Ser Phe Asp Tyr Ile Val Arg Glu Gly Lys Phe Gly Ala
            260                 265                 270         
Val Glu Gly Ala Val Ala Lys Tyr Met Gly Ala Ala Ala Met Tyr Leu
        275                 280                 285             
Ile Ser Lys Arg Leu Lys Ser Arg His Arg Leu Gln Asp Asn Val Arg
    290                 295                 300                 
Glu Asp Leu Tyr Glu Ala Ala Asp Lys Trp Val Ala Ala Val Gly Lys
305                 310                 315                 320 
Asp Arg Pro Phe Met Gly Gly Gln Lys Pro Asn Leu Ala Asp Leu Ala
                325                 330                 335     
Val Tyr Gly Val Leu Arg Val Met Glu Gly Leu Asp Ala Phe Asp Asp
            340                 345                 350         
Leu Met Gln His Thr His Ile Gln Pro Trp Tyr Leu Arg Val Glu Arg
        355                 360                 365             
Ala Ile Thr Glu Ala Ser Pro Ala His
    370                 375         


<210> 1528
<211> 526
<212> PRT
<213> Homo sapiens

<400> 1528
Met Pro Ala Val Ser Leu Pro Pro Lys Glu Asn Ala Leu Phe Lys Arg
 1               5                  10                  15      
Ile Leu Arg Cys Tyr Glu His Lys Gln Tyr Arg Asn Gly Leu Lys Phe
            20                  25                  30          
Cys Lys Gln Ile Leu Ser Asn Pro Lys Phe Ala Glu His Gly Glu Thr
        35                  40                  45              
Leu Ala Met Lys Gly Leu Thr Leu Asn Cys Leu Gly Lys Lys Glu Glu
    50                  55                  60                  
Ala Tyr Glu Leu Val Arg Arg Gly Leu Arg Asn Asp Leu Lys Ser His
65                  70                  75                  80  
Val Cys Trp His Val Tyr Gly Leu Leu Gln Arg Ser Asp Lys Lys Tyr
                85                  90                  95      
Asp Glu Ala Ile Lys Cys Tyr Arg Asn Ala Leu Lys Trp Asp Lys Asp
            100                 105                 110         
Asn Leu Gln Ile Leu Arg Asp Leu Ser Leu Leu Gln Ile Gln Met Arg
        115                 120                 125             
Asp Leu Glu Gly Tyr Arg Glu Thr Arg Tyr Gln Leu Leu Gln Leu Arg
    130                 135                 140                 
Pro Ala Gln Arg Ala Ser Trp Ile Gly Tyr Ala Ile Ala Tyr His Leu
145                 150                 155                 160 
Leu Glu Asp Tyr Glu Met Ala Ala Lys Ile Leu Glu Glu Phe Arg Lys
                165                 170                 175     
Thr Gln Gln Thr Ser Pro Asp Lys Val Asp Tyr Glu Tyr Ser Glu Leu
            180                 185                 190         
Leu Leu Tyr Gln Asn Gln Val Leu Arg Glu Ala Gly Leu Tyr Arg Glu
        195                 200                 205             
Ala Leu Glu His Leu Cys Thr Tyr Glu Lys Gln Ile Cys Asp Lys Leu
    210                 215                 220                 
Ala Val Glu Glu Thr Lys Gly Glu Leu Leu Leu Gln Leu Cys Arg Leu
225                 230                 235                 240 
Glu Asp Ala Ala Asp Val Tyr Arg Gly Leu Gln Glu Arg Asn Pro Glu
                245                 250                 255     
Asn Trp Ala Tyr Tyr Lys Gly Leu Glu Lys Ala Leu Lys Pro Ala Asn
            260                 265                 270         
Met Leu Glu Arg Leu Lys Ile Tyr Glu Glu Ala Trp Thr Lys Tyr Pro
        275                 280                 285             
Arg Gly Leu Val Pro Arg Arg Leu Pro Leu Asn Phe Leu Ser Gly Glu
    290                 295                 300                 
Lys Phe Lys Glu Cys Leu Asp Lys Phe Leu Arg Met Asn Phe Ser Lys
305                 310                 315                 320 
Gly Cys Pro Pro Val Phe Asn Thr Leu Arg Ser Leu Tyr Lys Asp Lys
                325                 330                 335     
Glu Lys Val Ala Ile Ile Glu Glu Leu Val Val Gly Tyr Glu Thr Ser
            340                 345                 350         
Leu Lys Ser Cys Arg Leu Phe Asn Pro Asn Asp Asp Gly Lys Glu Glu
        355                 360                 365             
Pro Pro Thr Thr Leu Leu Trp Val Gln Tyr Tyr Leu Ala Gln His Tyr
    370                 375                 380                 
Asp Lys Ile Gly Gln Pro Ser Ile Ala Leu Glu Tyr Ile Asn Thr Ala
385                 390                 395                 400 
Ile Glu Ser Thr Pro Thr Leu Ile Glu Leu Phe Leu Val Lys Ala Lys
                405                 410                 415     
Ile Tyr Lys His Ala Gly Asn Ile Lys Glu Ala Ala Arg Trp Met Asp
            420                 425                 430         
Glu Ala Gln Ala Leu Asp Thr Ala Asp Arg Phe Ile Asn Ser Lys Cys
        435                 440                 445             
Ala Lys Tyr Met Leu Lys Ala Asn Leu Ile Lys Glu Ala Glu Glu Met
    450                 455                 460                 
Cys Ser Lys Phe Thr Arg Glu Gly Thr Ser Ala Val Glu Asn Leu Asn
465                 470                 475                 480 
Glu Met Gln Cys Met Trp Phe Gln Thr Glu Cys Ala Gln Ala Tyr Lys
                485                 490                 495     
Ala Met Asn Lys Phe Gly Glu Ala Leu Lys Lys Cys His Glu Ile Glu
            500                 505                 510         
Arg Lys Ser Leu Met Thr Ser Leu Thr Phe Ile His Thr Val
        515                 520                 525     


<210> 1529
<211> 284
<212> PRT
<213> Homo sapiens

<400> 1529
Met Val Glu Phe Ala Pro Leu Phe Met Pro Trp Glu Arg Arg Leu Gln
 1               5                  10                  15      
Thr Leu Ala Val Leu Gln Phe Val Phe Ser Phe Leu Ala Leu Ala Glu
            20                  25                  30          
Ile Cys Thr Val Gly Phe Ile Ala Leu Leu Phe Thr Arg Phe Trp Leu
        35                  40                  45              
Leu Thr Val Leu Tyr Ala Ala Trp Trp Tyr Leu Asp Arg Asp Lys Pro
    50                  55                  60                  
Arg Gln Gly Gly Arg His Ile Gln Ala Ile Arg Cys Trp Thr Ile Trp
65                  70                  75                  80  
Lys Tyr Met Lys Asp Tyr Phe Pro Ile Ser Leu Val Lys Thr Ala Glu
                85                  90                  95      
Leu Asp Pro Ser Arg Asn Tyr Ile Ala Gly Phe His Pro His Gly Val
            100                 105                 110         
Leu Ala Val Gly Ala Phe Ala Asn Leu Cys Thr Glu Ser Thr Gly Phe
        115                 120                 125             
Ser Ser Ile Phe Pro Gly Ile Arg Pro His Leu Met Met Pro Thr Leu
    130                 135                 140                 
Trp Phe Arg Ala Pro Phe Phe Arg Asp Tyr Ile Met Ser Ala Gly Leu
145                 150                 155                 160 
Val Thr Ser Glu Lys Glu Ser Ala Ala His Ile Leu Asn Arg Lys Gly
                165                 170                 175     
Gly Gly Asn Leu Leu Gly Ile Ile Val Gly Gly Ala Gln Glu Ala Leu
            180                 185                 190         
Asp Ala Arg Pro Gly Ser Phe Thr Leu Leu Leu Arg Asn Arg Lys Gly
        195                 200                 205             
Phe Val Arg Leu Ala Leu Thr His Gly Tyr Gln Ala Ser Gly Lys Ser
    210                 215                 220                 
Thr Leu Gly Ser Val Gly Asn Trp Gln Gly Phe Tyr Phe Gly Gly Lys
225                 230                 235                 240 
Met Ala Glu Thr Asn Ala Asp Ser Ile Leu Val Glu Ile Phe Ser Pro
                245                 250                 255     
Phe Thr Ile Lys Ile Ile Phe Trp Cys Leu Met Pro Lys Tyr Leu Glu
            260                 265                 270         
Lys Phe Pro Gln Arg Arg Leu Ser Asp Leu Arg Asn
        275                 280                 


<210> 1530
<211> 179
<212> PRT
<213> Homo sapiens

<400> 1530
Met Val Val Gly Ala Phe Pro Met Ala Lys Leu Leu Tyr Leu Gly Ile
 1               5                  10                  15      
Arg Gln Val Ser Lys Pro Leu Ala Asn Arg Ile Lys Glu Ala Ala Arg
            20                  25                  30          
Arg Ser Glu Phe Phe Lys Thr Tyr Ile Cys Leu Pro Pro Ala Gln Leu
        35                  40                  45              
Tyr His Trp Val Glu Met Arg Thr Lys Met Arg Ile Met Gly Phe Arg
    50                  55                  60                  
Gly Thr Val Ile Lys Pro Leu Asn Glu Glu Ala Ala Ala Glu Leu Gly
65                  70                  75                  80  
Ala Glu Leu Leu Gly Glu Ala Thr Ile Phe Ile Val Gly Gly Gly Cys
                85                  90                  95      
Leu Val Leu Glu Tyr Trp Arg His Gln Ala Gln Gln Arg His Lys Glu
            100                 105                 110         
Glu Glu Gln Arg Ala Ala Trp Asn Ala Leu Arg Asp Glu Val Gly His
        115                 120                 125             
Leu Ala Leu Ala Leu Glu Ala Leu Gln Ala Gln Val Gln Ala Ala Pro
    130                 135                 140                 
Pro Gln Gly Ala Leu Glu Glu Leu Arg Thr Glu Leu Gln Glu Val Arg
145                 150                 155                 160 
Ala Gln Leu Cys Asn Pro Gly Arg Ser Ala Ser His Ala Val Pro Ala
                165                 170                 175     
Ser Lys Lys
            


<210> 1531
<211> 615
<212> PRT
<213> Homo sapiens

<400> 1531
Met Ala Val Tyr Val Gly Met Leu Arg Leu Gly Arg Leu Cys Ala Gly
 1               5                  10                  15      
Ser Ser Gly Val Leu Gly Ala Arg Ala Ala Leu Ser Arg Ser Trp Gln
            20                  25                  30          
Glu Ala Arg Leu Gln Gly Val Arg Phe Leu Ser Ser Arg Glu Val Asp
        35                  40                  45              
Arg Met Val Ser Thr Pro Ile Gly Gly Leu Ser Tyr Val Gln Gly Cys
    50                  55                  60                  
Thr Lys Lys His Leu Asn Ser Lys Thr Val Gly Gln Cys Leu Glu Thr
65                  70                  75                  80  
Thr Ala Gln Arg Val Pro Glu Arg Glu Ala Leu Val Val Leu His Glu
                85                  90                  95      
Asp Val Arg Leu Thr Phe Ala Gln Leu Lys Glu Glu Val Asp Lys Ala
            100                 105                 110         
Ala Ser Gly Leu Leu Ser Ile Gly Leu Cys Lys Gly Asp Arg Leu Gly
        115                 120                 125             
Met Trp Gly Pro Asn Ser Tyr Ala Trp Val Leu Met Gln Leu Ala Thr
    130                 135                 140                 
Ala Gln Ala Gly Ile Ile Leu Val Ser Val Asn Pro Ala Tyr Gln Ala
145                 150                 155                 160 
Met Glu Leu Glu Tyr Val Leu Lys Lys Val Gly Cys Lys Ala Leu Val
                165                 170                 175     
Phe Pro Lys Gln Phe Lys Thr Gln Gln Tyr Tyr Asn Val Leu Lys Gln
            180                 185                 190         
Ile Cys Pro Glu Val Glu Asn Ala Gln Pro Gly Ala Leu Lys Ser Gln
        195                 200                 205             
Arg Leu Pro Asp Leu Thr Thr Val Ile Ser Val Asp Ala Pro Leu Pro
    210                 215                 220                 
Gly Thr Leu Leu Leu Asp Glu Val Val Ala Ala Gly Ser Thr Arg Gln
225                 230                 235                 240 
His Leu Asp Gln Leu Gln Tyr Asn Gln Gln Phe Leu Ser Cys His Asp
                245                 250                 255     
Pro Ile Asn Ile Gln Phe Thr Ser Gly Thr Thr Gly Ser Pro Lys Gly
            260                 265                 270         
Ala Thr Leu Ser His Tyr Asn Ile Val Asn Asn Ser Asn Ile Leu Gly
        275                 280                 285             
Glu Arg Leu Lys Leu His Glu Lys Thr Pro Glu Gln Leu Arg Met Ile
    290                 295                 300                 
Leu Pro Asn Pro Leu Tyr His Cys Leu Gly Ser Val Ala Gly Thr Met
305                 310                 315                 320 
Met Cys Leu Met Tyr Gly Ala Thr Leu Ile Leu Ala Ser Pro Ile Phe
                325                 330                 335     
Asn Gly Lys Lys Ala Leu Glu Ala Ile Ser Arg Glu Arg Gly Thr Phe
            340                 345                 350         
Leu Tyr Gly Thr Pro Thr Met Phe Val Asp Ile Leu Asn Gln Pro Asp
        355                 360                 365             
Phe Ser Ser Tyr Asp Ile Ser Thr Met Cys Gly Gly Val Ile Ala Gly
    370                 375                 380                 
Ser Pro Ala Pro Pro Glu Leu Ile Arg Ala Ile Ile Asn Lys Ile Asn
385                 390                 395                 400 
Met Lys Asp Leu Val Val Ala Tyr Gly Thr Thr Glu Asn Ser Pro Val
                405                 410                 415     
Thr Phe Ala His Phe Pro Glu Asp Thr Val Glu Gln Lys Ala Glu Ser
            420                 425                 430         
Val Gly Arg Ile Met Pro His Thr Glu Ala Arg Ile Met Asn Met Glu
        435                 440                 445             
Ala Gly Thr Leu Ala Lys Leu Asn Thr Pro Gly Glu Leu Cys Ile Arg
    450                 455                 460                 
Gly Tyr Cys Val Met Leu Gly Tyr Trp Gly Glu Pro Gln Lys Thr Glu
465                 470                 475                 480 
Glu Ala Val Asp Gln Asp Lys Trp Tyr Trp Thr Gly Asp Val Ala Thr
                485                 490                 495     
Met Asn Glu Gln Gly Phe Cys Lys Ile Val Gly Arg Ser Lys Asp Met
            500                 505                 510         
Ile Ile Arg Gly Gly Glu Asn Ile Tyr Pro Ala Glu Leu Glu Asp Phe
        515                 520                 525             
Phe His Thr His Pro Lys Val Gln Glu Val Gln Val Val Gly Val Lys
    530                 535                 540                 
Asp Asp Arg Met Gly Glu Glu Ile Cys Ala Cys Ile Arg Leu Lys Asp
545                 550                 555                 560 
Gly Glu Glu Thr Thr Val Glu Glu Ile Lys Ala Phe Cys Lys Gly Lys
                565                 570                 575     
Ile Ser His Phe Lys Ile Pro Lys Tyr Ile Val Phe Val Thr Asn Tyr
            580                 585                 590         
Pro Leu Thr Ile Ser Gly Lys Ile Gln Lys Phe Lys Leu Arg Glu Gln
        595                 600                 605             
Met Glu Arg His Leu Asn Leu
    610                 615 


<210> 1532
<211> 289
<212> PRT
<213> Homo sapiens

<400> 1532
Met Val Cys Gly Arg Gln Leu Ser Gly Ala Gly Ser Glu Thr Leu Lys
 1               5                  10                  15      
Gln Arg Arg Thr Gln Ile Met Ser Arg Gly Leu Pro Lys Gln Lys Pro
            20                  25                  30          
Ile Glu Gly Val Lys Gln Val Ile Val Val Ala Ser Gly Lys Gly Gly
        35                  40                  45              
Val Gly Lys Ser Thr Thr Ala Val Asn Leu Ala Leu Ala Leu Ala Ala
    50                  55                  60                  
Asn Asp Ser Ser Lys Ala Ile Gly Leu Leu Asp Val Asp Val Tyr Gly
65                  70                  75                  80  
Pro Ser Val Pro Lys Met Met Asn Leu Lys Gly Asn Pro Glu Leu Ser
                85                  90                  95      
Gln Ser Asn Leu Met Arg Pro Leu Leu Asn Tyr Gly Ile Ala Cys Met
            100                 105                 110         
Ser Met Gly Phe Leu Val Glu Glu Ser Glu Pro Val Val Trp Arg Gly
        115                 120                 125             
Leu Met Val Met Ser Ala Ile Glu Lys Leu Leu Arg Gln Val Asp Trp
    130                 135                 140                 
Gly Gln Leu Asp Tyr Leu Val Val Asp Met Pro Pro Gly Thr Gly Asp
145                 150                 155                 160 
Val Gln Leu Ser Val Ser Gln Asn Ile Pro Ile Thr Gly Ala Val Ile
                165                 170                 175     
Val Ser Thr Pro Gln Asp Ile Ala Leu Met Asp Ala His Lys Gly Ala
            180                 185                 190         
Glu Met Phe Arg Arg Val His Val Pro Val Leu Gly Leu Val Gln Asn
        195                 200                 205             
Met Ser Val Phe Gln Cys Pro Lys Cys Lys His Lys Thr His Ile Phe
    210                 215                 220                 
Gly Ala Asp Gly Ala Arg Lys Leu Ala Gln Thr Leu Gly Leu Glu Val
225                 230                 235                 240 
Leu Gly Asp Ile Pro Leu His Leu Asn Ile Arg Glu Ala Ser Asp Thr
                245                 250                 255     
Gly Gln Pro Ile Val Phe Ser Gln Pro Glu Ser Asp Glu Ala Lys Ala
            260                 265                 270         
Tyr Leu Arg Ile Ala Val Glu Val Val Arg Arg Leu Pro Ser Pro Ser
        275                 280                 285             
Glu
    


<210> 1533
<211> 501
<212> PRT
<213> Homo sapiens

<400> 1533
Met Lys Lys Glu Gly Arg Lys Arg Trp Lys Arg Lys Glu Asp Lys Lys
 1               5                  10                  15      
Arg Val Val Val Ser Asn Leu Leu Phe Glu Gly Trp Ser His Lys Glu
            20                  25                  30          
Asn Pro Asn Arg His His Arg Gly Asn Gln Ile Lys Thr Ser Lys Tyr
        35                  40                  45              
Thr Val Leu Ser Phe Val Pro Lys Asn Ile Phe Glu Gln Leu His Arg
    50                  55                  60                  
Phe Ala Asn Leu Tyr Phe Val Gly Ile Ala Val Leu Asn Phe Ile Pro
65                  70                  75                  80  
Val Val Asn Ala Phe Gln Pro Glu Val Ser Met Ile Pro Ile Cys Val
                85                  90                  95      
Ile Leu Ala Val Thr Ala Ile Lys Asp Ala Trp Glu Asp Leu Arg Arg
            100                 105                 110         
Tyr Lys Ser Asp Lys Val Ile Asn Asn Arg Glu Cys Leu Ile Tyr Ser
        115                 120                 125             
Arg Lys Glu Gln Thr Tyr Val Gln Lys Cys Trp Lys Asp Val Arg Val
    130                 135                 140                 
Gly Asp Phe Ile Gln Met Lys Cys Asn Glu Ile Val Pro Ala Asp Ile
145                 150                 155                 160 
Leu Leu Leu Phe Ser Ser Asp Pro Asn Gly Ile Cys His Leu Glu Thr
                165                 170                 175     
Ala Ser Leu Asp Gly Glu Thr Asn Leu Lys Gln Arg Arg Val Val Lys
            180                 185                 190         
Gly Phe Ser Gln Gln Glu Val Gln Phe Glu Pro Glu Leu Phe His Asn
        195                 200                 205             
Thr Ile Val Cys Glu Lys Pro Asn Asn His Leu Asn Lys Phe Lys Gly
    210                 215                 220                 
Tyr Met Glu His Pro Asp Gln Thr Arg Thr Gly Phe Gly Cys Glu Ser
225                 230                 235                 240 
Leu Leu Leu Arg Gly Cys Thr Ile Arg Asn Thr Glu Met Ala Val Gly
                245                 250                 255     
Ile Val Ile Tyr Ala Gly His Glu Thr Lys Ala Met Leu Asn Asn Ser
            260                 265                 270         
Gly Pro Arg Tyr Lys Arg Ser Lys Ile Glu Arg Arg Met Asn Ile Asp
        275                 280                 285             
Ile Phe Phe Cys Ile Gly Ile Leu Ile Leu Met Cys Leu Ile Gly Ala
    290                 295                 300                 
Val Gly His Ser Ile Trp Asn Gly Thr Phe Glu Glu His Pro Pro Phe
305                 310                 315                 320 
Asp Val Pro Asp Ala Asn Gly Ser Phe Leu Pro Ser Ala Leu Gly Gly
                325                 330                 335     
Phe Tyr Met Phe Leu Thr Met Ile Ile Leu Leu Gln Val Leu Ile Pro
            340                 345                 350         
Ile Ser Leu Tyr Val Ser Ile Glu Leu Val Lys Leu Gly Gln Val Phe
        355                 360                 365             
Phe Leu Ser Asn Asp Leu Asp Leu Tyr Asp Glu Glu Thr Asp Leu Ser
    370                 375                 380                 
Ile Gln Cys Arg Ala Leu Asn Ile Ala Glu Asp Leu Gly Gln Ile Gln
385                 390                 395                 400 
Tyr Ile Phe Ser Asp Lys Thr Gly Thr Leu Thr Glu Asn Lys Met Val
                405                 410                 415     
Phe Arg Arg Cys Thr Ile Met Gly Ser Glu Tyr Ser His Gln Glu Asn
            420                 425                 430         
Gly Ile Glu Ala Pro Lys Gly Ser Ile Pro Leu Ser Lys Arg Lys Tyr
        435                 440                 445             
Pro Ala Leu Leu Arg Asn Glu Glu Ile Lys Asp Ile Leu Leu Ala Leu
    450                 455                 460                 
Leu Glu Ala Val Trp His Phe His Lys Leu Leu Pro Val Ser Leu Trp
465                 470                 475                 480 
Ser Ser Leu Ser Gln Ile Arg Ala Val Pro Ile Thr Cys Lys Leu Ser
                485                 490                 495     
Phe Val Tyr Lys Gly
            500     


<210> 1534
<211> 251
<212> PRT
<213> Homo sapiens

<400> 1534
Met Lys Ile Arg Arg Glu Val Val Glu His Val Glu Pro Leu Arg Pro
 1               5                  10                  15      
Tyr Glu Ser Leu Asp Thr Leu Lys Gln Phe Leu Gln Tyr His Gly Lys
            20                  25                  30          
Ile Leu Cys Phe Phe Cys Leu Trp Asp Asp Ser Val Ser Met Phe Gly
        35                  40                  45              
Asp Arg Arg Glu Leu Ile Leu His Tyr Phe Leu Cys Asp Asp Thr Ile
    50                  55                  60                  
Glu Ile Lys Glu Leu Leu Pro His Ser Ser Gly Arg Asp Ala Leu Lys
65                  70                  75                  80  
Met Phe Leu Arg Arg Ser Lys Leu Pro Lys Asn Cys Pro Pro Arg Val
                85                  90                  95      
Tyr Gln Pro Gly Gln Ile Thr Asp Arg Ala Val Leu Asn Ser Tyr Gly
            100                 105                 110         
Asp Phe Ile Lys Asn Gln Ala Asp Gly Tyr Leu Phe Asp Arg Tyr Lys
        115                 120                 125             
Leu Gly Lys Val Asp Gln Glu Phe Tyr Lys Asp Ser Asp Leu Ser Leu
    130                 135                 140                 
Gly Val Thr Ile Asn Val Trp Gly Arg Lys Val Leu Leu Tyr Asp Cys
145                 150                 155                 160 
Asp Glu Phe Thr Lys Ser Tyr Tyr Lys Ser Lys Tyr Gly Ile Glu Asn
                165                 170                 175     
Phe Thr Ser Val Ser Cys Lys Pro Pro Ser Pro Pro Pro Lys Ile Glu
            180                 185                 190         
Arg Lys Phe Pro Pro Tyr Asn Gly Phe Gly Ser Glu Glu Asp Ser Leu
        195                 200                 205             
Arg Asn Cys Ile Asp Leu Lys Pro Thr Pro His Arg Arg Asn Phe Lys
    210                 215                 220                 
Lys Phe Met Glu Lys Asp Ser Tyr Gly Ser Lys Ser Asn Ile Leu Arg
225                 230                 235                 240 
Phe Phe Cys Lys Thr Ser His Arg Gln Met Cys
                245                 250     


<210> 1535
<211> 202
<212> PRT
<213> Homo sapiens

<400> 1535
Met Ser Ala Ser Thr Ser Ser His Arg Pro Ile Lys Gly Ile Leu Lys
 1               5                  10                  15      
Asn Lys Ser Ser Ser Gly Ser Ser Val Ala Thr Ser Gly Gln Gln Ser
            20                  25                  30          
Gly Gly Thr Ile Gln Asp Val Lys Arg Lys Lys Ser Gln Lys Trp Asp
        35                  40                  45              
Glu Ser Ser Ile Leu Ala Ala His Arg Ala Thr Tyr Arg Asp Tyr Asp
    50                  55                  60                  
Leu Met Lys Ala Asn Glu Pro Gly Thr Ser Tyr Met Ser Val Gln Asp
65                  70                  75                  80  
Asn Gly Glu Asp Ser Val Arg Asp Val Glu Gly Glu Asp Ser Val Arg
                85                  90                  95      
Gly Val Glu Gly Lys Glu Ala Thr Asp Ala Ser Asp His Ser Cys Glu
            100                 105                 110         
Val Asp Glu Gln Glu Ser Ser Glu Ala Tyr Met Arg Lys Ile Leu Leu
        115                 120                 125             
His Lys Gln Glu Lys Lys Arg Gln Phe Glu Met Arg Arg Arg Leu His
    130                 135                 140                 
Tyr Asn Glu Glu Leu Asn Ile Lys Leu Ala Arg Gln Leu Met Trp Lys
145                 150                 155                 160 
Glu Leu Gln Ser Glu Asp Asn Glu Asn Glu Glu Thr Pro Gln Gly Thr
                165                 170                 175     
Asn Glu Glu Lys Thr Ala Ala Glu Glu Ser Glu Glu Ala Pro Leu Thr
            180                 185                 190         
Gly Gly Leu Gln Thr Gln Ser Cys Asp Pro
        195                 200         


<210> 1536
<211> 244
<212> PRT
<213> Homo sapiens

<400> 1536
Met Ala Ala Ala Ala Ser Pro Ala Phe Leu Leu Cys Leu Pro Leu Leu
 1               5                  10                  15      
His Leu Leu Ser Gly Trp Ser Arg Ala Gly Trp Val Asp Thr His Cys
            20                  25                  30          
Leu Cys Tyr Asp Phe Ile Ile Thr Pro Lys Ser Arg Pro Glu Pro Gln
        35                  40                  45              
Trp Cys Glu Val Gln Gly Leu Val Asp Glu Arg Pro Phe Leu His Tyr
    50                  55                  60                  
Asp Cys Val Asn His Lys Ala Lys Ala Phe Ala Ser Leu Gly Lys Lys
65                  70                  75                  80  
Val Asn Val Thr Lys Thr Trp Glu Glu Gln Thr Glu Thr Leu Arg Asp
                85                  90                  95      
Val Val Asp Phe Leu Lys Gly Gln Leu Leu Asp Ile Gln Val Glu Asn
            100                 105                 110         
Leu Ile Pro Ile Glu Pro Leu Thr Leu Gln Ala Arg Met Ser Cys Glu
        115                 120                 125             
His Glu Ala His Gly His Gly Arg Gly Ser Trp Gln Phe Leu Phe Asn
    130                 135                 140                 
Gly Gln Lys Phe Leu Leu Phe Asp Ser Asn Asn Arg Lys Trp Thr Ala
145                 150                 155                 160 
Leu His Pro Gly Ala Lys Lys Met Thr Glu Lys Trp Glu Lys Asn Arg
                165                 170                 175     
Asp Val Thr Met Phe Phe Gln Lys Ile Ser Leu Gly Asp Cys Lys Met
            180                 185                 190         
Trp Leu Glu Glu Phe Leu Met Tyr Trp Glu Gln Met Leu Asp Pro Thr
        195                 200                 205             
Lys Pro Pro Ser Leu Ala Pro Gly Thr Thr Gln Pro Lys Ala Met Ala
    210                 215                 220                 
Thr Thr Leu Ser Pro Trp Ser Leu Leu Ile Ile Phe Leu Cys Phe Ile
225                 230                 235                 240 
Leu Ala Gly Arg
                


<210> 1537
<211> 441
<212> PRT
<213> Homo sapiens

<400> 1537
Met Lys Lys Phe Phe Gln Glu Phe Lys Ala Asp Ile Lys Phe Lys Ser
 1               5                  10                  15      
Ala Gly Pro Gly Gln Lys Leu Lys Glu Ser Val Gly Glu Lys Ala His
            20                  25                  30          
Lys Glu Lys Pro Asn Gln Pro Ala Pro Arg Pro Pro Arg Gln Gly Pro
        35                  40                  45              
Thr Asn Glu Ala Gln Met Ala Ala Ala Ala Ala Leu Ala Arg Leu Glu
    50                  55                  60                  
Gln Lys Gln Ser Arg Ala Trp Gly Pro Thr Ser Gln Asp Thr Ile Arg
65                  70                  75                  80  
Asn Gln Val Arg Lys Glu Leu Gln Ala Glu Ala Thr Val Ser Gly Ser
                85                  90                  95      
Pro Glu Ala Pro Gly Thr Asn Val Val Ser Glu Pro Arg Glu Glu Gly
            100                 105                 110         
Ser Ala His Leu Ala Val Pro Gly Val Tyr Phe Thr Cys Pro Leu Thr
        115                 120                 125             
Gly Ala Thr Leu Arg Lys Asp Gln Arg Asp Ala Cys Ile Lys Glu Ala
    130                 135                 140                 
Ile Leu Leu His Phe Ser Thr Asp Pro Val Ala Ala Ser Ile Met Lys
145                 150                 155                 160 
Ile Tyr Thr Phe Asn Lys Asp Gln Asp Arg Val Lys Leu Gly Val Asp
                165                 170                 175     
Thr Ile Ala Lys Tyr Leu Asp Asn Ile His Leu His Pro Glu Glu Glu
            180                 185                 190         
Lys Tyr Arg Lys Ile Lys Leu Gln Asn Lys Val Phe Gln Glu Arg Ile
        195                 200                 205             
Asn Cys Leu Glu Gly Thr His Glu Phe Phe Glu Ala Ile Gly Phe Gln
    210                 215                 220                 
Lys Val Leu Leu Pro Ala Gln Asp Gln Glu Asp Pro Glu Glu Phe Tyr
225                 230                 235                 240 
Val Leu Ser Glu Thr Thr Leu Ala Gln Pro Gln Ser Leu Glu Arg His
                245                 250                 255     
Lys Glu Gln Leu Leu Ala Ala Glu Pro Val Arg Ala Lys Leu Asp Arg
            260                 265                 270         
Gln Arg Arg Val Phe Gln Pro Ser Pro Leu Ala Ser Gln Phe Glu Leu
        275                 280                 285             
Pro Gly Asp Phe Phe Asn Leu Thr Ala Glu Glu Ile Lys Arg Glu Gln
    290                 295                 300                 
Arg Leu Arg Ser Glu Ala Val Glu Arg Leu Ser Val Leu Arg Thr Lys
305                 310                 315                 320 
Ala Met Arg Glu Lys Glu Glu Gln Arg Gly Leu Arg Lys Tyr Asn Tyr
                325                 330                 335     
Thr Leu Leu Arg Val Arg Leu Pro Asp Gly Cys Leu Leu Gln Gly Thr
            340                 345                 350         
Phe Tyr Ala Arg Glu Arg Leu Gly Ala Val Tyr Gly Phe Val Arg Glu
        355                 360                 365             
Ala Leu Gln Ser Asp Trp Leu Pro Phe Glu Leu Leu Ala Ser Gly Gly
    370                 375                 380                 
Gln Lys Leu Ser Glu Asp Glu Asn Leu Ala Leu Asn Glu Cys Gly Leu
385                 390                 395                 400 
Val Pro Ser Ala Leu Leu Thr Phe Ser Trp Asp Met Ala Val Leu Glu
                405                 410                 415     
Asp Ile Lys Ala Ala Gly Ala Glu Pro Asp Ser Ile Leu Lys Pro Glu
            420                 425                 430         
Leu Leu Ser Ala Ile Glu Lys Leu Leu
        435                 440     


<210> 1538
<211> 605
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 604
<223> Xaa = Any Amino Acid

<400> 1538
Met Gln Cys Cys Gly Leu Val His Arg Arg Arg Val Arg Val Ser Tyr
 1               5                  10                  15      
Gly Ser Ala Asp Ser Tyr Thr Ser Arg Pro Ser Asp Ser Asp Val Ser
            20                  25                  30          
Leu Glu Glu Asp Arg Glu Ala Val Arg Arg Glu Ala Glu Arg Gln Ala
        35                  40                  45              
Gln Ala Gln Leu Glu Lys Ala Lys Thr Lys Pro Val Ala Phe Ala Val
    50                  55                  60                  
Arg Thr Asn Val Ser Tyr Ser Ala Ala His Glu Asp Asp Val Pro Val
65                  70                  75                  80  
Pro Gly Met Ala Ile Ser Phe Glu Ala Lys Asp Phe Leu His Val Lys
                85                  90                  95      
Glu Lys Phe Asn Asn Asp Trp Trp Ile Gly Arg Leu Val Lys Glu Gly
            100                 105                 110         
Cys Glu Ile Gly Phe Ile Pro Ser Pro Val Lys Leu Glu Asn Met Arg
        115                 120                 125             
Leu Gln His Glu Gln Arg Ala Lys Gln Gly Lys Phe Tyr Ser Ser Lys
    130                 135                 140                 
Ser Gly Gly Asn Ser Ser Ser Ser Leu Gly Asp Ile Val Pro Ser Ser
145                 150                 155                 160 
Arg Lys Ser Thr Pro Pro Ser Ser Ala Ile Asp Ile Asp Ala Thr Gly
                165                 170                 175     
Leu Asp Ala Glu Glu Asn Asp Ile Pro Ala Asn His Arg Ser Pro Lys
            180                 185                 190         
Pro Ser Ala Asn Ser Val Thr Ser Pro His Ser Lys Glu Lys Arg Met
        195                 200                 205             
Pro Phe Phe Lys Lys Thr Glu His Thr Pro Pro Tyr Asp Val Val Pro
    210                 215                 220                 
Ser Met Arg Pro Val Val Leu Val Gly Pro Ser Leu Lys Gly Tyr Glu
225                 230                 235                 240 
Val Thr Asp Met Met Gln Lys Ala Leu Phe Asp Phe Leu Lys His Arg
                245                 250                 255     
Phe Glu Gly Arg Ile Ser Ile Thr Arg Val Thr Ala Asp Ile Ser Leu
            260                 265                 270         
Ala Lys Arg Ser Val Leu Asn Asn Pro Ser Lys His Ala Ile Ile Glu
        275                 280                 285             
Arg Ser Asn Thr Arg Ser Ser Leu Ala Glu Val Gln Ser Glu Ile Glu
    290                 295                 300                 
Arg Ile Phe Glu Leu Ala Arg Thr Leu Gln Leu Val Val Leu Asp Ala
305                 310                 315                 320 
Asp Thr Ile Asn His Pro Ala Gln Leu Ser Lys Thr Ser Leu Ala Pro
                325                 330                 335     
Ile Ile Val Tyr Val Lys Ile Ser Ser Pro Lys Val Leu Gln Arg Leu
            340                 345                 350         
Ile Lys Ser Arg Gly Lys Ser Gln Ala Lys His Leu Asn Val Gln Met
        355                 360                 365             
Val Ala Ala Asp Lys Leu Ala Gln Cys Pro Pro Glu Leu Phe Asp Val
    370                 375                 380                 
Ile Leu Asp Glu Asn Gln Leu Glu Asp Ala Cys Glu His Leu Ala Asp
385                 390                 395                 400 
Tyr Leu Glu Ala Tyr Trp Lys Ala Thr His Pro Pro Ser Ser Ser Leu
                405                 410                 415     
Pro Asn Pro Leu Leu Ser Arg Thr Leu Ala Thr Ser Ser Leu Pro Leu
            420                 425                 430         
Ser Pro Thr Leu Ala Ser Asn Ser Gln Gly Ser Gln Gly Asp Gln Arg
        435                 440                 445             
Thr Asp Arg Ser Ala Pro Ile Arg Ser Ala Ser Gln Ala Glu Glu Glu
    450                 455                 460                 
Pro Ser Val Glu Pro Val Lys Lys Ser Gln His Arg Ser Ser Ser Ser
465                 470                 475                 480 
Ala Pro His His Asn His Arg Ser Gly Thr Ser Arg Gly Leu Ser Arg
                485                 490                 495     
Gln Glu Thr Phe Asp Ser Glu Thr Gln Glu Ser Arg Asp Ser Ala Tyr
            500                 505                 510         
Val Glu Pro Lys Glu Asp Tyr Ser His Asp His Val Asp His Tyr Ala
        515                 520                 525             
Ser His Arg Asp His Asn His Arg Asp Glu Thr His Gly Ser Ser Asp
    530                 535                 540                 
His Arg His Arg Glu Ser Arg His Arg Ser Arg Asp Val Asp Arg Glu
545                 550                 555                 560 
Gln Asp His Asn Glu Cys Asn Lys Gln Arg Ser Arg His Lys Ser Lys
                565                 570                 575     
Asp Arg Tyr Cys Glu Lys Asp Gly Glu Val Ile Ser Lys Lys Arg Asn
            580                 585                 590         
Glu Ala Gly Glu Trp Asn Arg Asp Val Tyr Ile Xaa Gln
        595                 600                 605 


<210> 1539
<211> 571
<212> PRT
<213> Homo sapiens

<400> 1539
Met Ala Ala Arg Trp Ser Ser Glu Asn Val Val Val Glu Phe Arg Asp
 1               5                  10                  15      
Ser Gln Ala Thr Ala Met Ser Val Asp Cys Leu Gly Gln His Ala Val
            20                  25                  30          
Leu Ser Gly Arg Arg Phe Leu Tyr Ile Val Asn Leu Asp Ala Pro Phe
        35                  40                  45              
Glu Gly His Arg Lys Ile Ser Arg Gln Ser Lys Trp Asp Ile Gly Ala
    50                  55                  60                  
Val Gln Trp Asn Pro His Asp Ser Phe Ala His Tyr Phe Ala Ala Ser
65                  70                  75                  80  
Ser Asn Gln Arg Val Asp Leu Tyr Lys Trp Lys Asp Gly Ser Gly Glu
                85                  90                  95      
Val Gly Thr Thr Leu Gln Gly His Thr Arg Val Ile Ser Asp Leu Asp
            100                 105                 110         
Trp Ala Val Phe Glu Pro Asp Leu Leu Val Thr Ser Ser Val Asp Thr
        115                 120                 125             
Tyr Ile Tyr Ile Trp Asp Ile Lys Asp Thr Arg Lys Pro Thr Val Ala
    130                 135                 140                 
Leu Ser Ala Val Ala Gly Ala Ser Gln Val Lys Trp Asn Lys Lys Asn
145                 150                 155                 160 
Ala Asn Cys Leu Ala Thr Ser His Asp Gly Asp Val Arg Ile Trp Asp
                165                 170                 175     
Lys Arg Lys Pro Ser Thr Ala Val Glu Tyr Leu Ala Ala His Leu Ser
            180                 185                 190         
Lys Ile His Gly Leu Asp Trp His Pro Asp Ser Glu His Ile Leu Ala
        195                 200                 205             
Thr Ser Ser Gln Asp Asn Ser Val Lys Phe Trp Asp Tyr Arg Gln Pro
    210                 215                 220                 
Arg Lys Tyr Leu Asn Ile Leu Pro Cys Gln Val Pro Val Trp Lys Ala
225                 230                 235                 240 
Arg Tyr Thr Pro Phe Ser Asn Gly Leu Val Thr Val Met Val Pro Gln
                245                 250                 255     
Leu Arg Arg Glu Asn Ser Leu Leu Leu Trp Asn Val Phe Asp Leu Asn
            260                 265                 270         
Thr Pro Val His Thr Phe Val Gly His Asp Asp Val Val Leu Glu Phe
        275                 280                 285             
Gln Trp Arg Lys Gln Lys Glu Gly Ser Lys Asp Tyr Gln Leu Val Thr
    290                 295                 300                 
Trp Ser Arg Asp Gln Thr Leu Arg Met Trp Arg Val Asp Ser Gln Met
305                 310                 315                 320 
Gln Arg Leu Cys Ala Asn Asp Ile Leu Asp Gly Val Asp Glu Phe Ile
                325                 330                 335     
Glu Ser Ile Ser Leu Leu Pro Glu Pro Glu Lys Thr Leu His Thr Glu
            340                 345                 350         
Asp Thr Asp His Gln His Thr Ala Ser His Gly Glu Glu Glu Ala Leu
        355                 360                 365             
Lys Glu Asp Pro Pro Arg Asn Leu Leu Glu Glu Arg Lys Ser Asp Gln
    370                 375                 380                 
Leu Gly Leu Pro Gln Thr Leu Gln Gln Glu Phe Ser Leu Ile Asn Val
385                 390                 395                 400 
Gln Ile Arg Asn Val Asn Val Glu Met Asp Ala Ala Asp Arg Ser Cys
                405                 410                 415     
Thr Val Ser Val His Cys Ser Asn His Arg Val Lys Met Leu Val Lys
            420                 425                 430         
Phe Pro Ala Gln Tyr Pro Asn Asn Ala Ala Pro Ser Phe Gln Phe Ile
        435                 440                 445             
Asn Pro Thr Thr Ile Thr Ser Thr Met Lys Ala Lys Leu Leu Lys Ile
    450                 455                 460                 
Leu Lys Asp Thr Ala Leu Gln Lys Val Lys Arg Gly Gln Ser Cys Leu
465                 470                 475                 480 
Glu Pro Cys Leu Arg Gln Leu Val Ser Cys Leu Glu Ser Phe Val Asn
                485                 490                 495     
Gln Glu Asp Ser Ala Ser Ser Asn Pro Phe Ala Leu Pro Asn Ser Val
            500                 505                 510         
Thr Pro Pro Leu Pro Thr Phe Ala Arg Val Thr Thr Ala Tyr Gly Ser
        515                 520                 525             
Tyr Gln Asp Ala Asn Ile Pro Phe Pro Arg Thr Ser Gly Ala Arg Phe
    530                 535                 540                 
Cys Gly Ala Gly Tyr Leu Val Tyr Phe Thr Arg Pro Met Thr Met His
545                 550                 555                 560 
Arg Ala Val Ser Pro Thr Glu Pro Thr Pro Arg
                565                 570     


<210> 1540
<211> 122
<212> PRT
<213> Homo sapiens

<400> 1540
Pro Met Phe Ile Val Asn Thr Asn Val Pro Arg Ala Ser Val Pro Asp
 1               5                  10                  15      
Gly Phe Leu Ser Glu Leu Thr Gln Gln Leu Ala Gln Ala Thr Gly Lys
            20                  25                  30          
Pro Pro Gln Tyr Ile Ala Val His Val Val Pro Asp Gln Leu Met Ala
        35                  40                  45              
Phe Gly Gly Ser Ser Glu Pro Cys Ala Leu Cys Ser Leu His Ser Ile
    50                  55                  60                  
Gly Lys Ile Gly Gly Ala Gln Asn Arg Ser Tyr Ser Lys Leu Leu Cys
65                  70                  75                  80  
Gly Leu Leu Ala Glu Arg Leu Arg Ile Ser Pro Asp Arg Val Tyr Ile
                85                  90                  95      
Asn Tyr Tyr Asp Met Asn Ala Ala Asn Val Gly Trp Asn Asn Ser Thr
            100                 105                 110         
Phe Ala Leu Glu His His His His His His
        115                 120         


<210> 1541
<211> 795
<212> PRT
<213> Homo sapiens

<400> 1541
Met Ala Val Leu Leu Leu Leu Leu Arg Ala Leu Gly Arg Gly Pro Gly
 1               5                  10                  15      
Pro Gly Pro Arg Pro Leu Trp Gly Pro Gly Pro Ala Trp Ser Pro Gly
            20                  25                  30          
Phe Pro Ala Arg Pro Gly Arg Gly Arg Pro Tyr Met Ala Ser Arg Pro
        35                  40                  45              
Pro Gly Asp Leu Ala Glu Ala Gly Gly Arg Ala Leu Gln Ser Leu Gln
    50                  55                  60                  
Leu Arg Leu Leu Thr Pro Thr Phe Glu Gly Ile Asn Gly Leu Leu Leu
65                  70                  75                  80  
Lys Gln His Leu Val Gln Asn Pro Val Arg Leu Trp Gln Leu Leu Gly
                85                  90                  95      
Gly Thr Phe Tyr Phe Asn Thr Ser Arg Leu Lys Gln Lys Asn Lys Glu
            100                 105                 110         
Lys Asp Lys Ser Lys Gly Lys Ala Pro Glu Glu Asp Glu Glu Glu Arg
        115                 120                 125             
Arg Arg Arg Glu Arg Asp Asp Gln Met Tyr Arg Glu Arg Leu Arg Thr
    130                 135                 140                 
Leu Leu Val Ile Ala Val Val Met Ser Leu Leu Asn Ala Leu Ser Thr
145                 150                 155                 160 
Ser Gly Gly Ser Ile Ser Trp Asn Asp Phe Val His Glu Met Leu Ala
                165                 170                 175     
Lys Gly Glu Val Gln Arg Val Gln Val Val Pro Glu Ser Asp Val Val
            180                 185                 190         
Glu Val Tyr Leu His Pro Gly Ala Val Val Phe Gly Arg Pro Arg Leu
        195                 200                 205             
Ala Leu Met Tyr Arg Met Gln Val Ala Asn Ile Asp Lys Phe Glu Glu
    210                 215                 220                 
Lys Leu Arg Ala Ala Glu Asp Glu Leu Asn Ile Glu Ala Lys Asp Arg
225                 230                 235                 240 
Ile Pro Val Ser Tyr Lys Arg Thr Gly Phe Phe Gly Asn Ala Leu Tyr
                245                 250                 255     
Ser Val Gly Met Thr Ala Val Gly Leu Ala Ile Leu Trp Tyr Val Phe
            260                 265                 270         
Arg Leu Ala Gly Met Thr Gly Arg Glu Gly Gly Phe Ser Ala Phe Asn
        275                 280                 285             
Gln Leu Lys Met Ala Arg Phe Thr Ile Val Asp Gly Lys Met Gly Lys
    290                 295                 300                 
Gly Val Ser Phe Lys Asp Val Ala Gly Met His Glu Ala Lys Leu Glu
305                 310                 315                 320 
Val Arg Glu Phe Val Asp Tyr Leu Lys Ser Pro Glu Arg Phe Leu Gln
                325                 330                 335     
Leu Gly Ala Lys Val Pro Lys Gly Ala Leu Leu Leu Gly Pro Pro Gly
            340                 345                 350         
Cys Gly Lys Thr Leu Leu Ala Lys Ala Val Ala Thr Glu Ala Gln Val
        355                 360                 365             
Pro Phe Leu Ala Met Ala Gly Pro Glu Phe Val Glu Val Ile Gly Gly
    370                 375                 380                 
Leu Gly Ala Ala Arg Val Arg Ser Leu Phe Lys Glu Ala Arg Ala Arg
385                 390                 395                 400 
Ala Pro Cys Ile Val Tyr Ile Asp Glu Ile Asp Ala Val Gly Lys Lys
                405                 410                 415     
Arg Ser Thr Thr Met Ser Gly Phe Ser Asn Thr Glu Glu Glu Gln Thr
            420                 425                 430         
Leu Asn Gln Leu Leu Val Glu Met Asp Gly Met Gly Thr Thr Asp His
        435                 440                 445             
Val Ile Val Leu Ala Ser Thr Asn Arg Ala Asp Ile Leu Asp Gly Ala
    450                 455                 460                 
Leu Met Arg Pro Gly Arg Leu Asp Arg His Val Phe Ile Asp Leu Pro
465                 470                 475                 480 
Thr Leu Gln Glu Arg Arg Glu Ile Phe Glu Gln His Leu Lys Ser Leu
                485                 490                 495     
Lys Leu Thr Gln Ser Ser Thr Phe Tyr Ser Gln Arg Leu Ala Glu Leu
            500                 505                 510         
Thr Pro Gly Phe Ser Gly Ala Asp Ile Ala Asn Ile Cys Asn Glu Ala
        515                 520                 525             
Ala Leu His Ala Ala Arg Glu Gly His Thr Ser Val His Thr Leu Asn
    530                 535                 540                 
Phe Glu Tyr Ala Val Glu Arg Val Leu Ala Gly Thr Ala Lys Lys Ser
545                 550                 555                 560 
Lys Ile Leu Ser Lys Glu Glu Gln Lys Val Val Ala Phe His Glu Ser
                565                 570                 575     
Gly His Ala Leu Val Gly Trp Met Leu Glu His Thr Glu Ala Val Met
            580                 585                 590         
Lys Val Ser Ile Thr Pro Arg Thr Asn Ala Ala Leu Gly Phe Ala Gln
        595                 600                 605             
Met Leu Pro Arg Asp Gln His Leu Phe Thr Lys Glu Gln Leu Phe Glu
    610                 615                 620                 
Arg Met Cys Met Ala Leu Gly Gly Arg Ala Ser Glu Ala Leu Ser Phe
625                 630                 635                 640 
Asn Glu Val Thr Ser Gly Ala Gln Asp Asp Leu Arg Lys Val Thr Arg
                645                 650                 655     
Ile Ala Tyr Ser Met Val Lys Gln Phe Gly Met Ala Pro Gly Ile Gly
            660                 665                 670         
Pro Ile Ser Phe Pro Glu Ala Gln Glu Gly Leu Met Gly Ile Gly Arg
        675                 680                 685             
Arg Pro Phe Ser Gln Gly Leu Gln Gln Met Met Asp His Glu Ala Arg
    690                 695                 700                 
Leu Leu Val Ala Lys Ala Tyr Arg His Thr Glu Lys Val Leu Gln Asp
705                 710                 715                 720 
Asn Leu Asp Lys Leu Gln Ala Leu Ala Asn Ala Leu Leu Glu Lys Glu
                725                 730                 735     
Val Ile Asn Tyr Glu Asp Ile Glu Ala Leu Ile Gly Pro Pro Pro His
            740                 745                 750         
Gly Pro Lys Lys Met Ile Ala Pro Gln Arg Trp Ile Asp Ala Gln Arg
        755                 760                 765             
Glu Lys Gln Asp Leu Gly Glu Glu Glu Thr Glu Glu Thr Gln Gln Pro
    770                 775                 780                 
Pro Leu Gly Gly Glu Glu Pro Thr Trp Pro Lys
785                 790                 795 


<210> 1542
<211> 1654
<212> PRT
<213> Homo sapiens

<400> 1542
Gly Trp Glu His Arg His Phe Arg Ser Trp Ser Arg His Cys Arg Arg
 1               5                  10                  15      
His Phe Val Ser Val Glu Lys Glu Ala Ser Val Ala Ala Gly Ser Gly
            20                  25                  30          
Arg Arg Ser Pro Ala Arg Arg Arg Arg Phe Ile Pro Glu Val Pro Pro
        35                  40                  45              
Val Ser Ser Pro Ile Pro Pro Pro Arg Ser Ala Cys Gly Glu Ala Gly
    50                  55                  60                  
Ala Ala Arg Glu Pro Gly Arg Gly Arg Gly Val Gly Arg Glu Ala Gly
65                  70                  75                  80  
Tyr Pro Glu Arg Leu Gln Leu Gln Leu Gln Arg Thr Ser Glu Gly Gly
                85                  90                  95      
Arg Gly Ala Met Ser Glu Gln Thr Pro Ala Glu Ala Gly Ala Ala Gly
            100                 105                 110         
Ala Arg Glu Asp Ala Cys Arg Asp Tyr Gln Ser Ser Leu Glu Asp Leu
        115                 120                 125             
Thr Phe Asn Ser Lys Pro His Ile Asn Met Leu Thr Ile Leu Ala Glu
    130                 135                 140                 
Glu Asn Leu Pro Phe Ala Lys Glu Ile Val Ser Leu Ile Glu Ala Gln
145                 150                 155                 160 
Thr Ala Lys Ala Pro Ser Ser Glu Lys Leu Pro Val Met Tyr Leu Met
                165                 170                 175     
Asp Ser Ile Val Lys Asn Val Gly Arg Glu Tyr Leu Thr Ala Phe Thr
            180                 185                 190         
Lys Asn Leu Val Ala Thr Phe Ile Cys Val Phe Glu Lys Val Asp Glu
        195                 200                 205             
Asn Thr Arg Lys Ser Leu Phe Lys Leu Arg Ser Thr Trp Asp Glu Ile
    210                 215                 220                 
Phe Pro Leu Lys Lys Leu Tyr Ala Leu Asp Val Arg Val Asn Ser Leu
225                 230                 235                 240 
Asp Pro Ala Trp Pro Ile Lys Pro Leu Pro Pro Asn Val Asn Thr Ser
                245                 250                 255     
Ser Ile His Val Asn Pro Lys Phe Leu Asn Lys Ser Pro Glu Glu Pro
            260                 265                 270         
Ser Thr Pro Gly Thr Val Val Ser Ser Pro Ser Ile Ser Thr Pro Pro
        275                 280                 285             
Ile Val Pro Asp Ile Gln Lys Asn Leu Thr Gln Glu Gln Leu Ile Arg
    290                 295                 300                 
Gln Gln Leu Leu Ala Lys Gln Lys Gln Leu Leu Glu Leu Gln Gln Lys
305                 310                 315                 320 
Lys Leu Glu Leu Glu Leu Glu Gln Ala Lys Ala Gln Leu Ala Val Ser
                325                 330                 335     
Leu Ser Val Gln Gln Glu Thr Ser Asn Leu Gly Pro Gly Ser Ala Pro
            340                 345                 350         
Ser Lys Leu His Val Ser Gln Ile Pro Pro Met Ala Val Lys Ala Pro
        355                 360                 365             
His Gln Val Pro Val Gln Ser Glu Lys Ser Arg Pro Gly Pro Ser Leu
    370                 375                 380                 
Gln Ile Gln Asp Leu Lys Gly Thr Asn Arg Asp Pro Arg Leu Asn Arg
385                 390                 395                 400 
Ile Ser Gln His Ser His Gly Lys Asp Gln Ser His Arg Lys Glu Phe
                405                 410                 415     
Leu Met Asn Thr Leu Asn Gln Ser Asp Thr Lys Thr Ser Lys Thr Ile
            420                 425                 430         
Pro Ser Glu Lys Leu Asn Ser Ser Lys Gln Glu Lys Ser Lys Ser Gly
        435                 440                 445             
Glu Lys Ile Thr Lys Lys Glu Leu Asp Gln Leu Asp Ser Lys Ser Lys
    450                 455                 460                 
Ser Lys Ser Lys Ser Pro Ser Pro Leu Lys Asn Lys Leu Ser His Thr
465                 470                 475                 480 
Lys Asp Leu Lys Asn Gln Glu Ser Glu Ser Met Arg Leu Ser Asp Met
                485                 490                 495     
Asn Lys Arg Asp Pro Arg Leu Lys Lys His Leu Gln Asp Lys Thr Asp
            500                 505                 510         
Gly Lys Asp Asp Asp Val Lys Glu Lys Arg Lys Thr Ala Glu Lys Lys
        515                 520                 525             
Asp Lys Asp Glu His Met Lys Ser Ser Glu His Arg Leu Ala Gly Ser
    530                 535                 540                 
Arg Asn Lys Ile Ile Asn Gly Ile Val Gln Lys Gln Asp Thr Ile Thr
545                 550                 555                 560 
Glu Glu Ser Glu Lys Gln Gly Thr Lys Pro Gly Arg Ser Ser Thr Arg
                565                 570                 575     
Lys Arg Ser Arg Ser Arg Ser Pro Lys Ser Arg Ser Pro Ile Ile His
            580                 585                 590         
Ser Pro Lys Arg Arg Asp Arg Arg Ser Pro Lys Arg Arg Gln Arg Ser
        595                 600                 605             
Met Ser Pro Thr Ser Thr Pro Lys Ala Gly Lys Ile Arg Gln Ser Gly
    610                 615                 620                 
Ala Lys Gln Ser His Met Glu Glu Phe Thr Pro Pro Ser Arg Glu Asp
625                 630                 635                 640 
Arg Asn Ala Lys Arg Ser Thr Lys Gln Asp Ile Arg Asp Pro Arg Arg
                645                 650                 655     
Met Lys Lys Thr Glu Glu Glu Arg Pro Gln Glu Thr Thr Asn Gln His
            660                 665                 670         
Ser Thr Lys Ser Gly Thr Glu Pro Lys Glu Asn Val Glu Asn Trp Gln
        675                 680                 685             
Ser Ser Lys Ser Ala Lys Arg Trp Lys Ser Gly Trp Glu Glu Asn Lys
    690                 695                 700                 
Ser Leu Gln Gln Val Asp Glu His Ser Lys Pro Pro His Leu Arg His
705                 710                 715                 720 
Arg Glu Ser Trp Ser Ser Thr Lys Gly Ile Leu Ser Pro Arg Ala Pro
                725                 730                 735     
Lys Gln Gln Gln His Arg Leu Ser Val Asp Ala Asn Leu Gln Ile Pro
            740                 745                 750         
Lys Glu Leu Thr Leu Ala Ser Lys Arg Glu Leu Leu Gln Lys Thr Ser
        755                 760                 765             
Glu Arg Leu Ala Ser Gly Glu Ile Thr Gln Asp Asp Phe Leu Val Val
    770                 775                 780                 
Val His Gln Ile Arg Gln Leu Phe Gln Tyr Gln Glu Gly Val Arg Glu
785                 790                 795                 800 
Glu Gln Arg Ser Pro Phe Asn Asp Arg Phe Pro Leu Lys Arg Pro Arg
                805                 810                 815     
Tyr Glu Asp Ser Asp Lys Pro Phe Val Asp Ser Pro Ala Ser Arg Phe
            820                 825                 830         
Ala Gly Leu Asp Thr Asn Gln Arg Leu Thr Ala Leu Ala Glu Asp Arg
        835                 840                 845             
Pro Leu Phe Asp Gly Pro Ser Arg Pro Ser Val Ala Arg Asp Gly Pro
    850                 855                 860                 
Thr Lys Met Ile Phe Glu Gly Pro Asn Lys Leu Ser Pro Arg Ile Asp
865                 870                 875                 880 
Gly Pro Pro Thr Pro Ala Ser Leu Arg Phe Asp Gly Ser Pro Gly Gln
                885                 890                 895     
Met Gly Gly Gly Gly Pro Leu Arg Phe Glu Gly Pro Gln Gly Gln Leu
            900                 905                 910         
Gly Gly Gly Cys Pro Leu Arg Phe Glu Gly Pro Pro Gly Pro Val Gly
        915                 920                 925             
Thr Pro Leu Arg Phe Glu Gly Pro Ile Gly Gln Ala Gly Gly Gly Gly
    930                 935                 940                 
Phe Arg Phe Glu Gly Ser Pro Gly Leu Arg Phe Glu Gly Ser Pro Gly
945                 950                 955                 960 
Gly Leu Arg Phe Glu Gly Pro Gly Gly Gln Pro Val Gly Gly Leu Arg
                965                 970                 975     
Phe Glu Gly His Arg Gly Gln Pro Val Gly Gly Leu Arg Phe Glu Gly
            980                 985                 990         
Pro His Gly Gln Pro Val Gly Gly Leu Arg Phe Asp Asn Pro Arg Gly
        995                 1000                1005            
Gln Pro Val Gly Gly Leu Arg Phe Glu Gly Gly His Gly Pro Ser Gly
    1010                1015                1020                
Ala Ala Ile Arg Phe Asp Gly Pro His Gly Gln Pro Gly Gly Gly Ile
1025                1030                1035                1040
Arg Phe Glu Gly Pro Leu Leu Gln Gln Gly Val Gly Met Arg Phe Glu
                1045                1050                1055    
Gly Pro His Gly Gln Ser Val Ala Gly Leu Arg Phe Glu Gly Gln His
            1060                1065                1070        
Asn Gln Leu Gly Gly Asn Leu Arg Phe Glu Gly Pro His Gly Gln Pro
        1075                1080                1085            
Gly Val Gly Ile Arg Phe Glu Gly Pro Leu Val Gln Gln Gly Gly Gly
    1090                1095                1100                
Met Arg Phe Glu Gly Pro Ser Val Pro Gly Gly Gly Leu Arg Ile Glu
1105                1110                1115                1120
Gly Pro Leu Gly Gln Gly Gly Pro Arg Phe Glu Gly Cys His Ala Leu
                1125                1130                1135    
Arg Phe Asp Gly Gln Pro Gly Gln Pro Ser Leu Leu Pro Arg Phe Asp
            1140                1145                1150        
Gly Leu His Gly Gln Pro Gly Pro Arg Phe Glu Arg Thr Pro Gly Gln
        1155                1160                1165            
Pro Gly Pro Gln Arg Phe Asp Gly Pro Pro Gly Gln Gln Val Gln Pro
    1170                1175                1180                
Arg Phe Asp Gly Val Pro Gln Arg Phe Asp Gly Pro Gln His Gln Gln
1185                1190                1195                1200
Ala Ser Arg Phe Asp Ile Pro Leu Gly Leu Gln Gly Thr Arg Phe Asp
                1205                1210                1215    
Asn His Pro Ser Gln Arg Leu Glu Ser Val Ser Phe Asn Gln Thr Gly
            1220                1225                1230        
Pro Tyr Asn Asp Pro Pro Gly Asn Ala Phe Asn Ala Pro Ser Gln Gly
        1235                1240                1245            
Leu Gln Phe Gln Arg His Glu Gln Ile Phe Asp Ser Pro Gln Gly Pro
    1250                1255                1260                
Asn Phe Asn Gly Pro His Gly Pro Gly Asn Gln Ser Phe Ser Asn Pro
1265                1270                1275                1280
Leu Asn Arg Ala Ser Gly His Tyr Phe Asp Glu Lys Asn Leu Gln Ser
                1285                1290                1295    
Ser Gln Phe Gly Asn Phe Gly Asn Ile Pro Ala Pro Met Thr Val Gly
            1300                1305                1310        
Asn Ile Gln Ala Ser Gln Gln Val Leu Ser Gly Val Ala Gln Pro Val
        1315                1320                1325            
Ala Phe Gly Gln Gly Gln Gln Phe Leu Pro Val His Pro Gln Asn Pro
    1330                1335                1340                
Gly Phe Val Gln Asn Pro Ser Gly Ala Leu Pro Lys Ala Tyr Pro Asp
1345                1350                1355                1360
Asn His Leu Ser Gln Val Asp Val Asn Glu Leu Phe Ser Lys Leu Leu
                1365                1370                1375    
Lys Thr Gly Ile Leu Lys Leu Ser Gln Thr Asp Ser Ala Thr Thr Gln
            1380                1385                1390        
Val Ser Glu Val Thr Ala Gln Pro Pro Pro Glu Glu Glu Glu Asp Gln
        1395                1400                1405            
Asn Glu Asp Gln Asp Val Pro Asp Leu Thr Asn Phe Thr Val Glu Glu
    1410                1415                1420                
Leu Lys Gln Arg Tyr Asp Ser Val Ile Asn Arg Leu Tyr Thr Gly Ile
1425                1430                1435                1440
Gln Cys Tyr Ser Cys Gly Met Arg Phe Thr Thr Ser Gln Thr Asp Val
                1445                1450                1455    
Tyr Ala Asp His Leu Asp Trp His Tyr Arg Gln Asn Arg Thr Glu Lys
            1460                1465                1470        
Asp Val Ser Arg Lys Val Thr His Arg Arg Trp Tyr Tyr Ser Leu Thr
        1475                1480                1485            
Asp Trp Ile Glu Phe Glu Glu Ile Ala Asp Leu Glu Glu Arg Ala Lys
    1490                1495                1500                
Ser Gln Phe Phe Glu Lys Val His Glu Glu Val Val Leu Lys Thr Gln
1505                1510                1515                1520
Glu Ala Ala Lys Glu Lys Glu Phe Gln Ser Val Pro Ala Gly Pro Ala
                1525                1530                1535    
Gly Ala Val Glu Ser Cys Glu Ile Cys Gln Glu Gln Phe Glu Gln Tyr
            1540                1545                1550        
Trp Asp Glu Glu Glu Glu Glu Trp His Leu Lys Asn Ala Ile Arg Val
        1555                1560                1565            
Asp Gly Lys Ile Tyr His Pro Ser Cys Tyr Glu Asp Tyr Gln Asn Thr
    1570                1575                1580                
Ser Ser Phe Asp Cys Thr Pro Ser Pro Ser Lys Thr Pro Val Glu Asn
1585                1590                1595                1600
Pro Leu Asn Ile Met Leu Asn Ile Val Lys Asn Glu Leu Gln Glu Pro
                1605                1610                1615    
Cys Asp Ser Pro Lys Val Lys Glu Glu Arg Ile Asp Thr Pro Pro Ala
            1620                1625                1630        
Cys Thr Glu Glu Ser Ile Ala Thr Pro Ser Glu Ile Lys Thr Glu Asn
        1635                1640                1645            
Asp Thr Val Glu Ser Val
    1650                


<210> 1543
<211> 914
<212> PRT
<213> Homo sapiens

<400> 1543
Met Ser Ser Pro Glu His Asn Gln Pro Pro Val Ala Leu Leu Asp Thr
 1               5                  10                  15      
Glu Glu Met Ser Val Pro Gln Asp Cys His Leu Leu Pro Ser Thr Glu
            20                  25                  30          
Ser Phe Ser Gly Gly Val Ser Glu Asp Val Ile Ser Arg Pro His Ser
        35                  40                  45              
Pro Pro Glu Ile Val Ser Arg Glu Glu Ser Pro Gln Cys Ser Glu Asn
    50                  55                  60                  
Gln Ser Ser Pro Met Gly Leu Glu Pro Pro Met Ser Leu Gly Lys Ala
65                  70                  75                  80  
Glu Asp Asn Gln Ser Ile Ser Ala Glu Val Glu Ser Gly Asp Thr Gln
                85                  90                  95      
Glu Leu Asn Val Asp Pro Leu Leu Lys Glu Ser Ser Thr Phe Thr Asp
            100                 105                 110         
Glu Asn Pro Ser Glu Thr Glu Glu Ser Glu Ala Ala Gly Gly Ile Gly
        115                 120                 125             
Lys Leu Glu Gly Glu Asp Gly Asp Val Lys Cys Leu Ser Glu Lys Asp
    130                 135                 140                 
Thr Tyr Asp Thr Ser Ile Asp Ser Leu Glu Glu Asn Leu Asp Lys Lys
145                 150                 155                 160 
Lys Lys Gly Lys Lys Phe Pro Glu Ala Ser Asp Arg Cys Leu Arg Ser
                165                 170                 175     
Gln Leu Ser Asp Ser Ser Ser Ala Asp Arg Cys Leu Arg Asn Gln Ser
            180                 185                 190         
Ser Asp Ser Ser Ser Ala Cys Leu Glu Ile Lys Val Pro Lys Asn Pro
        195                 200                 205             
Ser Ala Lys Arg Ser Lys Lys Glu Gly His Pro Gly Gly Thr Thr Pro
    210                 215                 220                 
Lys Gly Leu Leu Pro Asp Ser Phe His Thr Glu Thr Leu Glu Asp Thr
225                 230                 235                 240 
Glu Lys Pro Ser Val Asn Glu Arg Pro Ser Glu Lys Asp Ala Glu Gln
                245                 250                 255     
Glu Gly Glu Gly Gly Gly Ile Ile Thr Arg Gln Thr Leu Lys Asn Met
            260                 265                 270         
Leu Asp Lys Glu Val Lys Gly Leu Arg Gly Glu Ile Phe Pro Ser Arg
        275                 280                 285             
Asp Pro Ile Thr Thr Ala Gly Gln Pro Leu Pro Gly Glu Arg Leu Glu
    290                 295                 300                 
Ile Tyr Val Gln Ser Lys Met Asp Glu Lys Asn Ala His Ile Pro Ser
305                 310                 315                 320 
Glu Ser Ile Ala Cys Lys Arg Asp Pro Glu Gln Ala Lys Glu Glu Pro
                325                 330                 335     
Gly His Ile Pro Thr Gln His Val Glu Glu Ala Val Asn Glu Val Asp
            340                 345                 350         
Asn Glu Asn Thr Gln Gln Lys Asp Asp Glu Ser Asp Ala Pro Cys Ser
        355                 360                 365             
Ser Leu Gly Leu Ser Ser Ser Gly Ser Gly Asp Ala Ala Arg Ala Pro
    370                 375                 380                 
Lys Ser Val Pro Arg Pro Lys Arg Leu Thr Ser Ser Thr Tyr Asn Leu
385                 390                 395                 400 
Arg His Ala His Ser Leu Gly Ser Leu Asp Ala Ser Lys Val Thr Ser
                405                 410                 415     
Glu Lys Glu Ala Ala Gln Val Asn Pro Ile Met Pro Lys Glu Asn Gly
            420                 425                 430         
Ala Ser Glu Ser Gly Asp Pro Leu Asp Glu Asp Asp Val Asp Thr Val
        435                 440                 445             
Val Asp Glu Gln Pro Lys Phe Met Glu Trp Cys Ala Glu Glu Glu Asn
    450                 455                 460                 
Gln Glu Leu Ile Ala Asn Phe Asn Ala Gln Tyr Met Lys Val Gln Lys
465                 470                 475                 480 
Gly Trp Ile Gln Leu Glu Lys Glu Gly Gln Pro Thr Pro Arg Ala Arg
                485                 490                 495     
Asn Lys Ser Asp Lys Leu Lys Glu Ile Trp Lys Ser Lys Lys Arg Ser
            500                 505                 510         
Arg Lys Cys Arg Ser Ser Leu Glu Ser Gln Lys Cys Ser Pro Val Gln
        515                 520                 525             
Met Leu Phe Met Thr Asn Phe Lys Leu Ser Asn Val Cys Lys Trp Phe
    530                 535                 540                 
Leu Glu Thr Thr Glu Thr Arg Ser Leu Val Ile Val Lys Lys Leu Asn
545                 550                 555                 560 
Thr Arg Leu Pro Gly Gly Val Pro Pro Val Lys His Pro Leu Gln Lys
                565                 570                 575     
Tyr Ala Pro Ser Ser Leu Tyr Pro Ser Ser Leu Gln Ala Glu Arg Leu
            580                 585                 590         
Lys Lys His Leu Lys Lys Phe Pro Gly Ala Thr Pro Ala Lys Asn Asn
        595                 600                 605             
Trp Lys Met Gln Lys Leu Trp Ala Lys Phe Arg Glu Asn Pro Asp Gln
    610                 615                 620                 
Val Glu Pro Glu Asp Gly Ser Asp Val Ser Pro Gly Pro Asn Ser Glu
625                 630                 635                 640 
Asp Ser Ile Glu Glu Val Lys Glu Asp Arg Asn Ser His Pro Pro Ala
                645                 650                 655     
Asn Leu Pro Thr Pro Ala Ser Thr Arg Ile Leu Arg Lys Tyr Ser Asn
            660                 665                 670         
Ile Arg Gly Lys Leu Arg Ala Gln Gln Arg Leu Ile Lys Asn Glu Lys
        675                 680                 685             
Met Glu Cys Pro Asp Ala Leu Ala Val Glu Ser Lys Pro Ser Arg Lys
    690                 695                 700                 
Ser Val Cys Ile Asn Pro Leu Met Ser Pro Lys Leu Ala Leu Gln Val
705                 710                 715                 720 
Asp Ala Asp Gly Phe Pro Val Lys Pro Lys Ser Thr Glu Gly Met Lys
                725                 730                 735     
Gly Arg Lys Gly Lys Gln Val Ser Glu Ile Leu Pro Lys Ala Glu Val
            740                 745                 750         
Gln Ser Lys Arg Lys Arg Thr Glu Gly Ser Ser Pro Pro Asp Ser Lys
        755                 760                 765             
Asn Lys Gly Pro Thr Val Lys Ala Ser Lys Glu Lys His Ala Asp Gly
    770                 775                 780                 
Ala Thr Lys Thr Pro Ala Ala Lys Arg Pro Ala Ala Arg Asp Arg Ser
785                 790                 795                 800 
Ser Gln Pro Pro Lys Lys Thr Ser Leu Lys Glu Asn Lys Val Lys Ile
                805                 810                 815     
Pro Lys Lys Ser Ala Gly Lys Ser Cys Pro Pro Ser Arg Lys Glu Lys
            820                 825                 830         
Glu Asn Thr Asn Lys Arg Pro Ser Gln Ser Ile Ala Ser Glu Thr Leu
        835                 840                 845             
Thr Lys Pro Ala Lys Gln Lys Gly Ala Gly Glu Ser Ser Ser Arg Pro
    850                 855                 860                 
Gln Lys Ala Thr Asn Arg Lys Gln Ser Ser Gly Lys Thr Arg Ala Arg
865                 870                 875                 880 
Pro Ser Thr Lys Thr Pro Glu Ser Ser Ala Ala Gln Arg Lys Arg Lys
                885                 890                 895     
Leu Lys Ala Lys Leu Asp Cys Ser His Ser Lys Arg Arg Arg Leu Asp
            900                 905                 910         
Ala Lys
        


<210> 1544
<211> 491
<212> PRT
<213> Homo sapiens

<400> 1544
Met Ala Ser Arg Cys Trp Arg Trp Trp Gly Trp Ser Ala Trp Pro Arg
 1               5                  10                  15      
Thr Arg Leu Pro Pro Ala Gly Ser Thr Pro Ser Phe Cys His His Phe
            20                  25                  30          
Ser Thr Gln Glu Lys Thr Pro Gln Ile Cys Val Val Gly Ser Gly Pro
        35                  40                  45              
Ala Gly Phe Tyr Thr Ala Gln His Leu Leu Lys His Pro Gln Ala His
    50                  55                  60                  
Val Asp Ile Tyr Glu Lys Gln Pro Val Pro Phe Gly Leu Val Arg Phe
65                  70                  75                  80  
Gly Val Ala Pro Asp His Pro Glu Val Lys Asn Val Ile Asn Thr Phe
                85                  90                  95      
Thr Gln Thr Ala His Ser Gly Arg Cys Ala Phe Trp Gly Asn Val Glu
            100                 105                 110         
Val Gly Arg Asp Val Thr Val Pro Glu Leu Gln Glu Ala Tyr His Ala
        115                 120                 125             
Val Val Leu Ser Tyr Gly Ala Glu Asp His Arg Ala Leu Glu Ile Pro
    130                 135                 140                 
Gly Glu Glu Leu Pro Gly Val Cys Ser Ala Arg Ala Phe Val Gly Trp
145                 150                 155                 160 
Tyr Asn Gly Leu Pro Glu Asn Gln Glu Leu Glu Pro Asp Leu Ser Cys
                165                 170                 175     
Asp Thr Ala Val Ile Leu Gly Gln Gly Asn Val Ala Leu Asp Val Ala
            180                 185                 190         
Arg Ile Leu Leu Thr Pro Pro Glu His Leu Glu Arg Thr Asp Ile Thr
        195                 200                 205             
Lys Ala Ala Leu Gly Val Leu Arg Gln Ser Arg Val Lys Thr Val Trp
    210                 215                 220                 
Leu Val Gly Arg Arg Gly Pro Leu Gln Val Ala Phe Thr Ile Lys Glu
225                 230                 235                 240 
Leu Arg Glu Met Ile Gln Leu Pro Gly Ala Arg Pro Ile Leu Asp Pro
                245                 250                 255     
Val Asp Phe Leu Gly Leu Gln Asp Lys Ile Lys Glu Val Pro Arg Pro
            260                 265                 270         
Arg Lys Arg Leu Thr Glu Leu Leu Leu Arg Thr Ala Thr Glu Lys Pro
        275                 280                 285             
Gly Pro Ala Glu Ala Ala Arg Gln Ala Ser Ala Ser Arg Ala Trp Gly
    290                 295                 300                 
Leu Arg Phe Phe Arg Ser Pro Gln Gln Val Leu Pro Ser Pro Asp Gly
305                 310                 315                 320 
Arg Arg Ala Ala Gly Val Arg Leu Ala Val Thr Arg Leu Glu Gly Val
                325                 330                 335     
Asp Glu Ala Thr Arg Ala Val Pro Thr Gly Asp Met Glu Asp Leu Pro
            340                 345                 350         
Cys Gly Leu Val Leu Ser Ser Ile Gly Tyr Lys Ser Arg Pro Val Asp
        355                 360                 365             
Pro Ser Val Pro Phe Asp Ser Lys Leu Gly Val Ile Pro Asn Val Glu
    370                 375                 380                 
Gly Arg Val Met Asp Val Pro Gly Leu Tyr Cys Ser Gly Trp Val Lys
385                 390                 395                 400 
Arg Gly Pro Thr Gly Val Ile Ala Thr Thr Met Thr Asp Ser Phe Leu
                405                 410                 415     
Thr Gly Gln Met Leu Leu Gln Asp Leu Lys Ala Gly Leu Leu Pro Ser
            420                 425                 430         
Gly Pro Arg Pro Gly Tyr Ala Ala Ile Gln Ala Leu Leu Ser Ser Arg
        435                 440                 445             
Gly Val Arg Pro Val Ser Phe Ser Asp Trp Glu Lys Leu Asp Ala Glu
    450                 455                 460                 
Glu Val Ala Arg Gly Gln Gly Thr Gly Lys Pro Arg Glu Lys Leu Val
465                 470                 475                 480 
Asp Pro Gln Glu Met Leu Arg Leu Leu Gly His
                485                 490     


<210> 1545
<211> 686
<212> PRT
<213> Homo sapiens

<400> 1545
Met Ala Ala Ala Gln Glu Ala Asp Gly Ala Arg Ser Ala Val Val Ala
 1               5                  10                  15      
Ala Gly Gly Gly Ser Ser Gly Gln Val Thr Ser Asn Gly Ser Ile Gly
            20                  25                  30          
Arg Asp Pro Pro Ala Glu Thr Gln Pro Gln Asn Pro Pro Ala Gln Pro
        35                  40                  45              
Ala Pro Asn Ala Trp Gln Val Ile Lys Gly Val Leu Phe Arg Ile Phe
    50                  55                  60                  
Ile Ile Trp Ala Ile Ser Ser Trp Phe Arg Arg Gly Pro Ala Pro Gln
65                  70                  75                  80  
Asp Gln Ala Gly Pro Gly Gly Ala Pro Arg Val Ala Ser Arg Asn Leu
                85                  90                  95      
Phe Pro Lys Asp Thr Leu Met Asn Leu His Val Tyr Ile Ser Glu His
            100                 105                 110         
Glu His Phe Thr Asp Phe Asn Ala Thr Ser Ala Leu Phe Trp Glu Gln
        115                 120                 125             
His Asp Leu Val Tyr Gly Asp Trp Thr Ser Gly Glu Asn Ser Asp Gly
    130                 135                 140                 
Cys Tyr Glu His Phe Ala Glu Leu Asp Ile Pro Gln Ser Val Gln Gln
145                 150                 155                 160 
Asn Gly Ser Ile Tyr Ile His Val Tyr Phe Thr Lys Ser Gly Phe His
                165                 170                 175     
Pro Asp Pro Arg Gln Lys Ala Leu Tyr Arg Arg Leu Ala Thr Val His
            180                 185                 190         
Met Ser Arg Met Ile Asn Lys Tyr Lys Arg Arg Arg Phe Gln Lys Thr
        195                 200                 205             
Lys Asn Leu Leu Thr Gly Glu Thr Glu Ala Asp Pro Glu Met Ile Lys
    210                 215                 220                 
Arg Ala Glu Asp Tyr Gly Pro Val Glu Val Ile Ser His Trp His Pro
225                 230                 235                 240 
Asn Ile Thr Ile Asn Ile Val Asp Asp His Thr Pro Trp Val Lys Gly
                245                 250                 255     
Ser Val Pro Pro Pro Leu Asp Gln Tyr Val Lys Phe Asp Ala Val Ser
            260                 265                 270         
Gly Asp Tyr Tyr Pro Ile Ile Tyr Phe Asn Asp Tyr Trp Asn Leu Gln
        275                 280                 285             
Lys Asp Tyr Tyr Pro Ile Asn Glu Ser Leu Ala Ser Leu Pro Leu Arg
    290                 295                 300                 
Val Ser Phe Cys Pro Leu Ser Leu Trp Arg Trp Gln Leu Tyr Ala Ala
305                 310                 315                 320 
Gln Ser Thr Lys Ser Pro Trp Asn Phe Leu Gly Asp Glu Leu Tyr Glu
                325                 330                 335     
Gln Ser Asp Glu Glu Gln Asp Ser Val Lys Val Ala Leu Leu Glu Thr
            340                 345                 350         
Asn Pro Tyr Leu Leu Ala Leu Thr Ile Ile Val Ser Ile Val His Ser
        355                 360                 365             
Val Phe Glu Phe Leu Ala Phe Lys Asn Asp Ile Gln Phe Trp Asn Ser
    370                 375                 380                 
Arg Gln Ser Leu Glu Gly Leu Ser Val Arg Ser Val Phe Phe Gly Val
385                 390                 395                 400 
Phe Gln Ser Phe Val Val Leu Leu Tyr Ile Leu Asp Asn Glu Thr Asn
                405                 410                 415     
Phe Val Val Gln Val Ser Val Phe Ile Gly Val Leu Ile Asp Leu Trp
            420                 425                 430         
Lys Ile Thr Lys Val Met Asp Val Arg Leu Asp Arg Glu His Arg Val
        435                 440                 445             
Ala Gly Ile Phe Pro Arg Leu Ser Phe Lys Asp Lys Ser Thr Tyr Ile
    450                 455                 460                 
Glu Ser Ser Thr Lys Val Tyr Asp Asp Met Ala Phe Arg Tyr Leu Ser
465                 470                 475                 480 
Trp Ile Leu Phe Pro Leu Leu Gly Cys Tyr Ala Val Tyr Ser Leu Leu
                485                 490                 495     
Tyr Leu Glu His Lys Gly Trp Tyr Ser Trp Val Leu Ser Met Leu Tyr
            500                 505                 510         
Gly Phe Leu Leu Thr Phe Gly Phe Ile Thr Met Thr Pro Gln Leu Phe
        515                 520                 525             
Ile Asn Tyr Lys Leu Lys Ser Val Ala His Leu Pro Trp Arg Met Leu
    530                 535                 540                 
Thr Tyr Lys Ala Leu Asn Thr Phe Ile Asp Asp Leu Phe Ala Phe Val
545                 550                 555                 560 
Ile Lys Met Pro Val Met Tyr Arg Ile Gly Cys Leu Arg Asp Asp Val
                565                 570                 575     
Val Phe Phe Ile Tyr Leu Tyr Gln Arg Trp Ile Tyr Arg Val Asp Pro
            580                 585                 590         
Thr Arg Val Asn Glu Phe Gly Met Ser Gly Glu Asp Pro Thr Ala Ala
        595                 600                 605             
Ala Pro Val Ala Glu Val Pro Thr Ala Ala Gly Ala Leu Thr Pro Thr
    610                 615                 620                 
Pro Ala Pro Thr Thr Thr Thr Ala Thr Arg Glu Glu Ala Ser Thr Ser
625                 630                 635                 640 
Leu Pro Thr Lys Pro Thr Gln Gly Ala Ser Ser Ala Ser Glu Pro Gln
                645                 650                 655     
Gly Leu Phe Val Glu Ala Leu Ser Val Pro Leu Ser Leu Cys Val Ser
            660                 665                 670         
Ser His Leu Ala Leu Pro Ala Gln His His Trp Glu Ser Trp
        675                 680                 685     


<210> 1546
<211> 157
<212> PRT
<213> Homo sapiens

<400> 1546
Ala Arg Gly Leu Phe Ile Ser Arg Asn Arg Gln Phe Ser Tyr Leu Ile
 1               5                  10                  15      
Glu Asn Met Ala Arg Asp Cys Gly Glu Tyr Ala His Thr Arg Tyr Phe
            20                  25                  30          
Arg Gly Gly Met Leu Thr Asn Ala Arg Leu Leu Phe Gly Pro Thr Val
        35                  40                  45              
Arg Leu Pro Asp Leu Ile Ile Phe Leu His Thr Leu Asn Asn Ile Phe
    50                  55                  60                  
Glu Pro His Val Ala Val Arg Asp Ala Ala Lys Met Asn Ile Pro Thr
65                  70                  75                  80  
Val Gly Ile Val Asp Thr Asn Cys Asn Pro Cys Leu Ile Thr Tyr Pro
                85                  90                  95      
Val Pro Gly Asn Asp Asp Ser Pro Leu Ala Val His Leu Tyr Cys Arg
            100                 105                 110         
Leu Phe Gln Thr Ala Ile Thr Arg Ala Lys Glu Lys Arg Gln Gln Val
        115                 120                 125             
Glu Ala Leu Tyr Arg Leu Gln Gly Gln Lys Glu Pro Gly Asp Gln Gly
    130                 135                 140                 
Pro Ala His Pro Pro Gly Ala Asp Met Ser His Ser Leu
145                 150                 155         


<210> 1547
<211> 177
<212> PRT
<213> Homo sapiens

<400> 1547
Met Gly Arg Ala Cys Thr Ile Thr Ser Pro Ala Ser Arg Ser Cys Ala
 1               5                  10                  15      
Gly Ser Arg Gly Ala Arg Asn Ser Arg Arg Phe Pro Thr Phe Thr Asn
            20                  25                  30          
Thr Ser Ala Ser Pro Leu Lys Thr Lys Arg Thr Ser Gly Gln Lys Ala
        35                  40                  45              
Glu Ala Gln Ala Arg Lys Trp Ile Ser Leu Ser Val Arg Leu Lys Lys
    50                  55                  60                  
Val Ser Ser Lys Ala Gln Ser Arg Met Ser Ala Tyr Ala Arg Leu Ser
65                  70                  75                  80  
Ala Arg Ser Arg Ala Arg Gln Trp Val Arg Ala Pro Ser Pro Thr Ser
                85                  90                  95      
Ser Ala Pro Pro Glu Pro Ala Pro Leu Gly Thr Pro Ser Lys Asn Thr
            100                 105                 110         
Arg Arg Thr Ser Ala Pro Cys Thr Arg Pro Ser Ala Pro His Val Trp
        115                 120                 125             
Arg Thr Ala Trp Arg Arg Ser Lys Ser Ser Ala Thr Asp Leu Thr Ala
    130                 135                 140                 
Ile Ser Arg Ser Gly Arg Pro Pro Gly Ala Pro Ser Pro Arg His Leu
145                 150                 155                 160 
Cys Gly Trp Leu Met Ser Ser Gly Asn Arg Arg Trp Ser Leu Ala Arg
                165                 170                 175     
Lys
    


<210> 1548
<211> 517
<212> PRT
<213> Homo sapiens

<400> 1548
Ser Lys Leu Gly Leu Leu Asp Asn His Ser Ser Glu Phe Asn Val Thr
 1               5                  10                  15      
Arg Asn Tyr Leu Asp Trp Leu Thr Ser Ile Pro Trp Gly Lys Tyr Ser
            20                  25                  30          
Asn Glu Asn Leu Asp Leu Ala Arg Ala Gln Ala Val Leu Glu Glu Asp
        35                  40                  45              
His Tyr Gly Met Glu Asp Val Lys Lys Arg Ile Leu Glu Phe Ile Ala
    50                  55                  60                  
Val Ser Gln Leu Arg Gly Ser Thr Gln Gly Lys Ile Leu Cys Phe Tyr
65                  70                  75                  80  
Gly Pro Pro Gly Val Gly Lys Thr Ser Ile Ala Arg Ser Ile Ala Arg
                85                  90                  95      
Ala Leu Asn Arg Glu Tyr Phe Arg Phe Ser Val Gly Gly Met Thr Asp
            100                 105                 110         
Val Ala Glu Ile Lys Gly His Arg Arg Thr Tyr Val Gly Ala Met Pro
        115                 120                 125             
Gly Lys Ile Ile Gln Cys Leu Lys Lys Thr Lys Thr Glu Asn Pro Leu
    130                 135                 140                 
Ile Leu Ile Asp Glu Val Asp Lys Ile Gly Arg Gly Tyr Gln Gly Asp
145                 150                 155                 160 
Pro Ser Ser Ala Leu Leu Glu Leu Leu Asp Pro Glu Gln Asn Ala Asn
                165                 170                 175     
Phe Leu Asp His Tyr Leu Asp Val Pro Val Asp Leu Ser Lys Val Leu
            180                 185                 190         
Phe Ile Cys Thr Ala Asn Val Thr Asp Thr Ile Pro Glu Pro Leu Arg
        195                 200                 205             
Asp Arg Met Glu Met Ile Asn Val Ser Gly Tyr Val Ala Gln Glu Lys
    210                 215                 220                 
Leu Ala Ile Ala Glu Arg Tyr Leu Val Pro Gln Ala Arg Ala Leu Cys
225                 230                 235                 240 
Gly Leu Asp Glu Ser Lys Ala Lys Leu Ser Ser Asp Val Leu Thr Leu
                245                 250                 255     
Leu Ile Lys Gln Tyr Cys Arg Glu Ser Gly Val Arg Asn Leu Gln Lys
            260                 265                 270         
Gln Val Glu Lys Val Leu Arg Lys Ser Ala Tyr Lys Ile Val Ser Gly
        275                 280                 285             
Glu Ala Glu Ser Val Glu Val Thr Pro Glu Asn Leu Gln Asp Phe Val
    290                 295                 300                 
Gly Lys Pro Val Phe Thr Val Glu Arg Met Tyr Asp Val Thr Pro Pro
305                 310                 315                 320 
Gly Val Val Met Gly Leu Ala Trp Thr Ala Met Gly Gly Ser Thr Leu
                325                 330                 335     
Phe Val Glu Thr Ser Leu Arg Arg Pro Gln Asp Lys Asp Ala Lys Gly
            340                 345                 350         
Asp Lys Asp Gly Ser Leu Glu Val Thr Gly Gln Leu Gly Glu Val Met
        355                 360                 365             
Lys Glu Ser Ala Arg Ile Ala Tyr Thr Phe Ala Arg Ala Phe Leu Met
    370                 375                 380                 
Gln His Ala Pro Ala Asn Asp Tyr Leu Val Thr Ser His Ile His Leu
385                 390                 395                 400 
His Val Pro Glu Gly Ala Thr Pro Lys Asp Gly Pro Ser Ala Gly Cys
                405                 410                 415     
Thr Ile Val Thr Ala Leu Leu Ser Leu Ala Met Gly Arg Pro Val Arg
            420                 425                 430         
Gln Asn Leu Ala Met Thr Gly Glu Val Ser Leu Thr Gly Lys Ile Leu
        435                 440                 445             
Pro Val Gly Gly Ile Lys Glu Lys Thr Ile Ala Ala Lys Arg Ala Gly
    450                 455                 460                 
Val Thr Cys Ile Val Leu Pro Ala Glu Asn Lys Lys Asp Phe Tyr Asp
465                 470                 475                 480 
Leu Ala Ala Phe Ile Thr Glu Gly Leu Glu Val His Phe Val Glu His
                485                 490                 495     
Tyr Arg Glu Ile Phe Asp Ile Ala Phe Pro Asp Glu Gln Ala Glu Ala
            500                 505                 510         
Leu Ala Val Glu Arg
        515         


<210> 1549
<211> 170
<212> PRT
<213> Homo sapiens

<400> 1549
Ile Ala Met Arg Arg Asp Arg Gly Pro Lys Pro Ala Leu Gly Gly Ala
 1               5                  10                  15      
Gly Glu Val Glu Pro Gly Gly Met Ala Ala Ser Pro Thr Gly Arg Pro
            20                  25                  30          
Arg Arg Leu Gln Arg Tyr Leu Gln Ser Gly Glu Phe Asp Gln Phe Arg
        35                  40                  45              
Asp Phe Pro Ile Phe Glu Ser Asn Phe Val Gln Val Thr Arg Leu Gly
    50                  55                  60                  
Glu Val Ala Asn Glu Val Thr Met Gly Val Ala Ala Ser Ser Pro Ala
65                  70                  75                  80  
Leu Glu Leu Pro Asp Leu Leu Leu Leu Ala Gly Pro Ala Lys Glu Asn
                85                  90                  95      
Gly His Leu Gln Leu Phe Gly Leu Phe Pro Leu Lys Phe Val Gln Leu
            100                 105                 110         
Phe Val His Asp Lys Ser Arg Cys Gln Leu Glu Val Lys Leu Asn Thr
        115                 120                 125             
Ser Arg Thr Phe Tyr Leu Gln Leu Arg Ala Pro Leu Lys Thr Arg Asp
    130                 135                 140                 
Arg Glu Phe Gly Gln Trp Val Arg Leu Leu Tyr Arg Leu Arg Phe Leu
145                 150                 155                 160 
Ser Ala Ser Ala Val Pro Phe Thr Gln Glu
                165                 170 


<210> 1550
<211> 298
<212> PRT
<213> Homo sapiens

<400> 1550
Phe Glu Thr Thr Asp Glu Ser Leu Arg Ser His Phe Glu Gln Trp Gly
 1               5                  10                  15      
Thr Leu Thr Asp Cys Val Val Met Arg Asp Pro Asn Thr Lys Arg Ser
            20                  25                  30          
Arg Gly Phe Gly Phe Val Thr Tyr Ala Thr Val Glu Glu Val Asp Ala
        35                  40                  45              
Ala Met Asn Ala Arg Pro His Lys Val Asp Gly Arg Val Val Glu Pro
    50                  55                  60                  
Lys Arg Ala Val Ser Arg Glu Asp Ser Gln Arg Pro Gly Ala His Leu
65                  70                  75                  80  
Thr Val Lys Lys Ile Phe Val Gly Gly Ile Lys Glu Asp Thr Glu Glu
                85                  90                  95      
His His Leu Arg Asp Tyr Phe Glu Gln Tyr Gly Lys Ile Glu Val Ile
            100                 105                 110         
Glu Ile Met Thr Asp Arg Gly Ser Gly Lys Lys Arg Gly Phe Ala Phe
        115                 120                 125             
Val Thr Phe Asp Asp His Asp Ser Val Asp Lys Ile Val Ile Gln Lys
    130                 135                 140                 
Tyr His Thr Val Asn Gly His Asn Cys Glu Val Arg Lys Ala Leu Ser
145                 150                 155                 160 
Lys Gln Glu Met Ala Ser Ala Ser Ser Ser Gln Arg Gly Arg Ser Gly
                165                 170                 175     
Ser Gly Asn Phe Gly Gly Gly Arg Gly Gly Gly Phe Gly Gly Asn Asp
            180                 185                 190         
Asn Phe Gly Arg Gly Gly Asn Phe Ser Gly Arg Gly Gly Phe Gly Gly
        195                 200                 205             
Ser Arg Gly Gly Gly Gly Tyr Gly Gly Ser Gly Asp Gly Tyr Asn Gly
    210                 215                 220                 
Phe Gly Asn Asp Gly Ser Asn Phe Gly Gly Gly Gly Ser Tyr Asn Asp
225                 230                 235                 240 
Phe Gly Asn Tyr Asn Asn Gln Ser Ser Asn Phe Gly Pro Met Lys Gly
                245                 250                 255     
Gly Asn Phe Gly Gly Arg Ser Ser Gly Pro Tyr Gly Gly Gly Gly Gln
            260                 265                 270         
Tyr Phe Ala Lys Pro Arg Asn Gln Gly Gly Tyr Gly Gly Ser Ser Ser
        275                 280                 285             
Ser Ser Ser Tyr Gly Ser Gly Arg Arg Phe
    290                 295             


<210> 1551
<211> 87
<212> PRT
<213> Homo sapiens

<400> 1551
Met Gln Ala Arg Gly Phe Gly Ser Asp Gln Ser Glu Asn Val Asp Arg
 1               5                  10                  15      
Gly Ala Gly Ser Ile Arg Glu Ala Gly Gly Ala Phe Gly Lys Arg Glu
            20                  25                  30          
Gln Ala Glu Glu Glu Arg Tyr Phe Arg Ala Gln Ser Arg Glu Gln Leu
        35                  40                  45              
Ala Ala Leu Lys Lys His His Glu Glu Glu Ile Val His His Lys Lys
    50                  55                  60                  
Glu Ile Glu Arg Leu Gln Lys Glu Ile Glu Arg His Lys Gln Lys Ile
65                  70                  75                  80  
Lys Met Leu Lys His Asp Asp
                85          


<210> 1552
<211> 162
<212> PRT
<213> Homo sapiens

<400> 1552
Trp Glu Pro Ser Gly Ala Ala Val Ser Arg Ser Pro Leu Ser Pro Pro
 1               5                  10                  15      
Ser Arg Pro Phe Ala Ser Arg Glu Pro Ala Gly Phe Arg Ala Ala Leu
            20                  25                  30          
Ala Asp Pro Pro Gly Met Pro Arg Tyr Glu Leu Ala Leu Ile Leu Lys
        35                  40                  45              
Ala Met Gln Arg Pro Glu Thr Ala Ala Thr Leu Lys Arg Thr Ile Glu
    50                  55                  60                  
Ala Leu Met Asp Arg Gly Ala Ile Val Arg Asp Leu Glu Asn Leu Gly
65                  70                  75                  80  
Glu Arg Ala Leu Pro Tyr Arg Ile Ser Ala His Ser Gln Gln His Asn
                85                  90                  95      
Arg Gly Gly Tyr Phe Leu Val Asp Phe Tyr Ala Pro Thr Ala Ala Val
            100                 105                 110         
Glu Ser Met Val Glu His Leu Ser Arg Asp Ile Asp Val Ile Arg Gly
        115                 120                 125             
Asn Ile Val Lys His Pro Leu Thr Gln Glu Leu Lys Glu Cys Glu Gly
    130                 135                 140                 
Ile Val Pro Val Pro Leu Ala Glu Lys Leu Tyr Ser Thr Lys Lys Arg
145                 150                 155                 160 
Lys Lys
        


<210> 1553
<211> 558
<212> PRT
<213> Homo sapiens

<400> 1553
Met Ala Ala Leu Thr Arg Asp Pro Gln Phe Gln Lys Leu Gln Gln Trp
 1               5                  10                  15      
Tyr Arg Glu His Arg Ser Glu Leu Asn Leu Arg Arg Leu Phe Asp Ala
            20                  25                  30          
Asn Lys Asp Arg Phe Asn His Phe Ser Leu Thr Leu Asn Thr Asn His
        35                  40                  45              
Gly His Ile Leu Val Asp Tyr Ser Lys Asn Leu Val Thr Glu Asp Val
    50                  55                  60                  
Met Arg Met Leu Val Asp Leu Ala Lys Ser Arg Gly Val Glu Ala Ala
65                  70                  75                  80  
Arg Glu Arg Met Phe Asn Gly Glu Lys Ile Asn Tyr Thr Glu Gly Arg
                85                  90                  95      
Ala Val Leu His Val Ala Leu Arg Asn Arg Ser Asn Thr Pro Ile Leu
            100                 105                 110         
Val Asp Gly Lys Asp Val Met Pro Glu Val Asn Lys Val Leu Asp Lys
        115                 120                 125             
Met Lys Ser Phe Cys Gln Arg Val Arg Ser Gly Asp Trp Lys Gly Tyr
    130                 135                 140                 
Thr Gly Lys Thr Ile Thr Asp Val Ile Asn Ile Gly Ile Gly Gly Ser
145                 150                 155                 160 
Asp Leu Gly Pro Leu Met Val Thr Glu Ala Leu Lys Pro Tyr Ser Ser
                165                 170                 175     
Gly Gly Pro Arg Val Trp Tyr Val Ser Asn Ile Asp Gly Thr His Ile
            180                 185                 190         
Ala Lys Thr Leu Ala Gln Leu Asn Pro Glu Ser Ser Leu Phe Ile Ile
        195                 200                 205             
Ala Ser Lys Thr Phe Thr Thr Gln Glu Thr Ile Thr Asn Ala Glu Thr
    210                 215                 220                 
Ala Lys Glu Trp Phe Leu Gln Ala Ala Lys Asp Pro Ser Ala Val Ala
225                 230                 235                 240 
Lys His Phe Val Ala Leu Ser Thr Asn Thr Thr Lys Val Lys Glu Phe
                245                 250                 255     
Gly Ile Asp Pro Gln Asn Met Phe Glu Phe Trp Asp Trp Val Gly Gly
            260                 265                 270         
Arg Tyr Ser Leu Trp Ser Ala Ile Gly Leu Ser Ile Ala Leu His Val
        275                 280                 285             
Gly Phe Asp Asn Phe Glu Gln Leu Leu Ser Gly Ala His Trp Met Asp
    290                 295                 300                 
Gln His Phe Arg Thr Thr Pro Leu Glu Lys Asn Ala Pro Val Leu Leu
305                 310                 315                 320 
Ala Leu Leu Gly Ile Trp Tyr Ile Asn Cys Phe Gly Cys Glu Thr His
                325                 330                 335     
Ala Met Leu Pro Tyr Asp Gln Tyr Leu His Arg Phe Ala Ala Tyr Phe
            340                 345                 350         
Gln Gln Gly Asp Met Glu Ser Asn Gly Lys Tyr Ile Thr Lys Ser Gly
        355                 360                 365             
Thr Arg Val Asp His Gln Thr Gly Pro Ile Val Trp Gly Glu Pro Gly
    370                 375                 380                 
Thr Asn Gly Gln His Ala Phe Tyr Gln Leu Ile His Gln Gly Thr Lys
385                 390                 395                 400 
Met Ile Pro Cys Asp Phe Leu Ile Pro Val Gln Thr Gln His Pro Ile
                405                 410                 415     
Arg Lys Gly Leu His His Lys Ile Leu Leu Ala Asn Phe Leu Ala Gln
            420                 425                 430         
Thr Glu Ala Leu Met Arg Gly Lys Ser Thr Glu Glu Ala Arg Lys Glu
        435                 440                 445             
Leu Gln Ala Ala Gly Lys Ser Pro Glu Asp Leu Glu Arg Leu Leu Pro
    450                 455                 460                 
His Lys Val Phe Glu Gly Asn Arg Pro Thr Asn Ser Ile Val Phe Thr
465                 470                 475                 480 
Lys Leu Thr Pro Phe Met Leu Gly Ala Leu Val Ala Met Tyr Glu His
                485                 490                 495     
Lys Ile Phe Val Gln Gly Ile Ile Trp Asp Ile Asn Ser Phe Asp Gln
            500                 505                 510         
Trp Gly Val Glu Leu Gly Lys Gln Leu Ala Lys Lys Ile Glu Pro Glu
        515                 520                 525             
Leu Asp Gly Ser Ala Gln Val Thr Ser His Asp Ala Ser Thr Asn Gly
    530                 535                 540                 
Leu Ile Asn Phe Ile Lys Gln Gln Arg Glu Ala Arg Val Gln
545                 550                 555             


<210> 1554
<211> 484
<212> PRT
<213> Homo sapiens

<400> 1554
Met Asp Leu Gly Lys Asp Gln Ser His Leu Lys His His Gln Thr Pro
 1               5                  10                  15      
Asp Pro His Gln Glu Glu Asn His Ser Pro Glu Val Ile Gly Thr Trp
            20                  25                  30          
Ser Leu Arg Asn Arg Glu Leu Leu Arg Lys Arg Lys Ala Glu Val His
        35                  40                  45              
Glu Lys Glu Thr Ser Gln Trp Leu Phe Gly Glu Gln Lys Lys Arg Lys
    50                  55                  60                  
Gln Gln Arg Thr Gly Lys Gly Asn Arg Arg Gly Arg Lys Arg Gln Gln
65                  70                  75                  80  
Asn Thr Glu Leu Lys Val Glu Pro Gln Pro Gln Ile Glu Lys Glu Ile
                85                  90                  95      
Val Glu Lys Ala Leu Ala Pro Ile Glu Lys Lys Thr Glu Pro Pro Gly
            100                 105                 110         
Ser Ile Thr Lys Val Phe Pro Ser Val Ala Ser Pro Gln Lys Val Val
        115                 120                 125             
Pro Glu Glu His Phe Ser Glu Ile Cys Gln Glu Ser Asn Ile Tyr Gln
    130                 135                 140                 
Glu Asn Phe Ser Glu Tyr Gln Glu Ile Ala Val Gln Asn His Ser Ser
145                 150                 155                 160 
Glu Thr Cys Gln His Val Ser Glu Pro Glu Asp Leu Ser Pro Lys Met
                165                 170                 175     
Tyr Gln Glu Ile Ser Val Leu Gln Asp Asn Ser Ser Lys Ile Cys Gln
            180                 185                 190         
Asp Met Lys Glu Pro Glu Asp Asn Ser Pro Asn Thr Cys Gln Val Ile
        195                 200                 205             
Ser Val Ile Gln Asp His Pro Phe Lys Met Tyr Gln Asp Met Ala Lys
    210                 215                 220                 
Arg Glu Asp Leu Ala Pro Lys Met Cys Gln Glu Ala Ala Val Pro Lys
225                 230                 235                 240 
Ile Leu Pro Cys Pro Thr Ser Glu Asp Thr Ala Asp Leu Ala Gly Cys
                245                 250                 255     
Ser Leu Gln Ala Tyr Pro Lys Pro Asp Val Pro Lys Gly Tyr Ile Leu
            260                 265                 270         
Asp Thr Asp Gln Asn Pro Ala Glu Pro Glu Glu Tyr Asn Glu Thr Asp
        275                 280                 285             
Gln Gly Ile Ala Glu Thr Glu Gly Leu Phe Pro Lys Ile Gln Glu Ile
    290                 295                 300                 
Ala Glu Pro Lys Asp Leu Ser Thr Lys Thr His Gln Glu Ser Ala Glu
305                 310                 315                 320 
Pro Lys Tyr Leu Pro His Lys Thr Cys Asn Glu Ile Ile Val Pro Lys
                325                 330                 335     
Ala Pro Ser His Lys Thr Ile Gln Glu Thr Pro His Ser Glu Asp Tyr
            340                 345                 350         
Ser Ile Glu Ile Asn Gln Glu Thr Pro Gly Ser Glu Lys Tyr Ser Pro
        355                 360                 365             
Glu Thr Tyr Gln Glu Ile Pro Gly Leu Glu Glu Tyr Ser Pro Glu Ile
    370                 375                 380                 
Tyr Gln Glu Thr Ser Gln Leu Glu Glu Tyr Ser Pro Glu Ile Tyr Gln
385                 390                 395                 400 
Glu Thr Pro Gly Pro Glu Asp Leu Ser Thr Glu Thr Tyr Lys Asn Lys
                405                 410                 415     
Asp Val Pro Lys Glu Cys Phe Pro Glu Pro His Gln Glu Thr Gly Gly
            420                 425                 430         
Pro Gln Gly Gln Asp Pro Lys Ala His Gln Glu Asp Ala Lys Asp Ala
        435                 440                 445             
Tyr Thr Phe Pro Gln Glu Met Lys Glu Lys Pro Lys Glu Glu Pro Gly
    450                 455                 460                 
Ile Pro Ala Ile Leu Asn Glu Ser His Pro Glu Asn Asp Val Tyr Ser
465                 470                 475                 480 
Tyr Val Leu Phe
                


<210> 1555
<211> 305
<212> PRT
<213> Homo sapiens

<400> 1555
Met Ala Ser Arg Gln Pro Glu Val Pro Ala Leu Glu Ala Ser Ala Pro
 1               5                  10                  15      
Leu Gly Lys Met Ser Leu Pro Ile Gly Ile Tyr Arg Arg Ala Val Ser
            20                  25                  30          
Tyr Asp Asp Thr Leu Glu Asp Pro Ala Pro Met Thr Pro Pro Pro Ser
        35                  40                  45              
Asp Met Gly Ser Val Pro Trp Arg Pro Val Ile Pro Glu Arg Lys Tyr
    50                  55                  60                  
Gln His Leu Ala Lys Val Glu Glu Gly Glu Ala Ser Leu Pro Ser Pro
65                  70                  75                  80  
Ala Met Thr Leu Ser Ser Ala Ile Asp Ser Val Asp Lys Val Pro Val
                85                  90                  95      
Val Lys Ala Lys Ala Thr His Val Ile Met Asn Ser Leu Ile Thr Lys
            100                 105                 110         
Gln Thr Gln Glu Ser Ile Gln His Phe Glu Arg Gln Ala Gly Leu Arg
        115                 120                 125             
Asp Ala Gly Tyr Thr Pro His Lys Gly Leu Thr Thr Glu Glu Thr Lys
    130                 135                 140                 
Tyr Leu Arg Val Ala Glu Ala Leu His Lys Leu Lys Leu Gln Ser Gly
145                 150                 155                 160 
Glu Val Thr Lys Glu Glu Arg Gln Pro Ala Ser Ala Gln Ser Thr Pro
                165                 170                 175     
Ser Thr Thr Pro His Ser Ser Pro Lys Gln Arg Pro Arg Gly Trp Phe
            180                 185                 190         
Thr Ser Gly Ser Ser Thr Ala Leu Pro Gly Pro Asn Pro Ser Thr Met
        195                 200                 205             
Asp Ser Gly Ser Gly Asp Lys Asp Arg Asn Leu Ser Asp Lys Trp Ser
    210                 215                 220                 
Leu Phe Gly Pro Arg Ser Leu Gln Lys Tyr Asp Ser Gly Ser Phe Ala
225                 230                 235                 240 
Thr Gln Ala Tyr Arg Gly Ala Gln Lys Pro Ser Pro Leu Glu Leu Ile
                245                 250                 255     
Arg Ala Gln Ala Asn Arg Met Ala Glu Asp Pro Ala Ala Leu Lys Pro
            260                 265                 270         
Pro Lys Met Asp Ile Pro Val Met Glu Gly Lys Lys Gln Pro Pro Arg
        275                 280                 285             
Ala His Asn Leu Lys Pro Arg Asp Leu Asn Val Leu Thr Pro Thr Gly
    290                 295                 300                 
Phe
305 


<210> 1556
<211> 167
<212> PRT
<213> Homo sapiens

<400> 1556
Met Asn Val Val Lys Ala Ser Pro Gln Ser Ala Leu Leu Leu Tyr Ile
 1               5                  10                  15      
Ser Glu Leu Ile Gln Glu Lys Asn Pro Met Asn Ala Met Asn Val Val
            20                  25                  30          
Lys Pro Ser Ala Arg Lys Tyr Ala Ser Tyr Asn Met Arg Asp Val Ile
        35                  40                  45              
Gln Glu Arg Leu Pro Leu Tyr Val Pro Ser Ala Glu Asn Pro Ile His
    50                  55                  60                  
Thr Asn Met Ala Ser Leu Pro Ile Arg Glu Phe Thr Gln Glu Arg Asn
65                  70                  75                  80  
Leu Met Ser Ala Met Asn Val Glu Arg Pro Ser Pro Gln Ser Gln Tyr
                85                  90                  95      
Ser Met Tyr Ile Lys Glu Arg Ile Gln Glu Arg Gly Arg Met Asp Ala
            100                 105                 110         
Val Ile Val Arg Lys Pro Ser Pro Thr Tyr Gln Thr Leu Ser Asn Ile
        115                 120                 125             
Arg Lys Cys Thr Gln Glu Lys Trp Val Glu Ser Val Lys Leu Lys Thr
    130                 135                 140                 
Pro Val Met Glu Ser His Ser Ser Phe Leu Ile Ser Glu Leu Met Gln
145                 150                 155                 160 
Lys Lys Thr Leu Leu Val Pro
                165         


<210> 1557
<211> 1011
<212> PRT
<213> Homo sapiens

<400> 1557
Met Val Ala Thr Leu Leu Ser Tyr Gly Ala Val Ile Glu Val Gln Asn
 1               5                  10                  15      
Lys Ala Ser Leu Thr Pro Leu Leu Leu Ala Ile Gln Lys Arg Ser Lys
            20                  25                  30          
Gln Thr Val Glu Phe Leu Leu Thr Lys Asn Ala Asn Ala Asn Ala Phe
        35                  40                  45              
Asn Glu Ser Lys Cys Thr Ala Leu Met Leu Ala Ile Cys Glu Gly Ser
    50                  55                  60                  
Ser Glu Ile Val Gly Met Leu Leu Gln Gln Asn Val Asp Val Phe Ala
65                  70                  75                  80  
Glu Asp Ile His Gly Ile Thr Ala Glu Arg Tyr Ala Ala Ala Arg Gly
                85                  90                  95      
Val Asn Tyr Ile His Gln Gln Leu Leu Glu His Ile Arg Lys Leu Pro
            100                 105                 110         
Lys Asn Pro Gln Asn Thr Asn Pro Glu Gly Thr Ser Thr Gly Thr Pro
        115                 120                 125             
Asp Glu Ala Ala Pro Leu Ala Glu Arg Thr Pro Asp Thr Ala Glu Ser
    130                 135                 140                 
Leu Leu Glu Lys Thr Pro Asp Glu Ala Ala Arg Leu Val Glu Gly Thr
145                 150                 155                 160 
Ser Ala Lys Ile Gln Cys Leu Gly Lys Ala Thr Ser Gly Lys Phe Glu
                165                 170                 175     
Gln Ser Thr Glu Glu Thr Pro Arg Lys Ile Leu Arg Pro Thr Lys Glu
            180                 185                 190         
Thr Ser Glu Lys Phe Ser Trp Pro Ala Lys Glu Arg Ser Arg Lys Ile
        195                 200                 205             
Thr Trp Glu Glu Lys Glu Thr Ser Val Lys Thr Glu Cys Val Ala Gly
    210                 215                 220                 
Val Thr Pro Asn Lys Thr Glu Val Leu Glu Lys Gly Thr Ser Asn Met
225                 230                 235                 240 
Ile Ala Cys Pro Thr Lys Glu Thr Ser Thr Lys Ala Ser Thr Asn Val
                245                 250                 255     
Asp Val Ser Ser Val Glu Pro Ile Phe Ser Leu Phe Gly Thr Arg Thr
            260                 265                 270         
Ile Glu Asn Ser Gln Cys Thr Lys Val Glu Glu Asp Phe Asn Leu Ala
        275                 280                 285             
Thr Lys Ile Ile Ser Lys Ser Ala Ala Gln Asn Tyr Thr Cys Leu Pro
    290                 295                 300                 
Asp Ala Thr Tyr Gln Lys Asp Ile Lys Thr Ile Asn His Lys Ile Glu
305                 310                 315                 320 
Asp Gln Met Phe Pro Ser Glu Ser Lys Arg Glu Glu Asp Glu Glu Tyr
                325                 330                 335     
Ser Trp Asp Ser Gly Ser Leu Phe Glu Ser Ser Ala Lys Thr Gln Val
            340                 345                 350         
Cys Ile Pro Glu Ser Met Tyr Gln Lys Val Met Glu Ile Asn Arg Glu
        355                 360                 365             
Val Glu Glu Leu Pro Glu Lys Pro Ser Ala Phe Lys Pro Ala Val Glu
    370                 375                 380                 
Met Gln Lys Thr Val Pro Asn Lys Ala Phe Glu Leu Lys Asn Glu Gln
385                 390                 395                 400 
Thr Leu Arg Ala Ala Gln Met Phe Pro Ser Glu Ser Lys Gln Lys Asp
                405                 410                 415     
Asp Glu Glu Asn Ser Trp Asp Ser Glu Ser Pro Cys Glu Thr Val Ser
            420                 425                 430         
Gln Lys Asp Val Tyr Leu Pro Lys Ala Thr His Gln Lys Glu Phe Asp
        435                 440                 445             
Thr Leu Ser Gly Lys Leu Glu Glu Ser Pro Val Lys Asp Gly Leu Leu
    450                 455                 460                 
Lys Pro Thr Cys Gly Arg Lys Val Ser Leu Pro Asn Lys Ala Leu Glu
465                 470                 475                 480 
Leu Lys Asp Arg Glu Thr Phe Lys Ala Glu Ser Pro Asp Lys Asp Gly
                485                 490                 495     
Leu Leu Lys Pro Thr Cys Gly Arg Lys Val Ser Leu Pro Asn Lys Ala
            500                 505                 510         
Leu Glu Leu Lys Asp Arg Glu Thr Leu Lys Ala Glu Ser Pro Asp Asn
        515                 520                 525             
Asp Gly Leu Leu Lys Pro Thr Cys Gly Arg Lys Val Ser Leu Pro Asn
    530                 535                 540                 
Lys Ala Leu Glu Leu Lys Asp Arg Glu Thr Phe Lys Ala Ala Gln Met
545                 550                 555                 560 
Phe Pro Ser Glu Ser Lys Gln Lys Asp Asp Glu Glu Asn Ser Trp Asp
                565                 570                 575     
Phe Glu Ser Phe Leu Glu Thr Leu Leu Gln Asn Asp Val Cys Leu Pro
            580                 585                 590         
Lys Ala Thr His Gln Lys Glu Phe Asp Thr Leu Ser Gly Lys Leu Glu
        595                 600                 605             
Glu Ser Pro Asp Lys Asp Gly Leu Leu Lys Pro Thr Cys Gly Met Lys
    610                 615                 620                 
Ile Ser Leu Pro Asn Lys Ala Leu Glu Leu Lys Asp Arg Glu Thr Phe
625                 630                 635                 640 
Lys Ala Glu Asp Val Ser Ser Val Glu Ser Thr Phe Ser Leu Phe Gly
                645                 650                 655     
Lys Pro Thr Thr Glu Asn Ser Gln Ser Thr Lys Val Glu Glu Asp Phe
            660                 665                 670         
Asn Leu Thr Thr Lys Glu Gly Ala Thr Lys Thr Val Thr Gly Gln Gln
        675                 680                 685             
Glu Arg Asp Ile Gly Ile Ile Glu Arg Ala Pro Gln Asp Gln Thr Asn
    690                 695                 700                 
Lys Met Pro Thr Ser Glu Leu Gly Arg Lys Glu Asp Thr Lys Ser Thr
705                 710                 715                 720 
Ser Asp Ser Glu Ile Ile Ser Val Ser Asp Thr Gln Asn Tyr Glu Cys
                725                 730                 735     
Leu Pro Glu Ala Thr Tyr Gln Lys Glu Ile Lys Thr Thr Asn Gly Lys
            740                 745                 750         
Ile Glu Glu Ser Pro Glu Lys Pro Ser His Phe Glu Pro Ala Thr Glu
        755                 760                 765             
Met Gln Asn Ser Val Pro Asn Lys Gly Leu Glu Trp Lys Asn Lys Gln
    770                 775                 780                 
Thr Leu Arg Ala Asp Ser Thr Thr Leu Ser Lys Ile Leu Asp Ala Leu
785                 790                 795                 800 
Pro Ser Cys Glu Arg Gly Arg Glu Leu Lys Lys Asp Asn Cys Glu Gln
                805                 810                 815     
Ile Thr Ala Lys Met Glu Gln Met Lys Asn Lys Phe Cys Val Leu Gln
            820                 825                 830         
Lys Glu Leu Ser Glu Ala Lys Glu Ile Lys Ser Gln Leu Glu Asn Gln
        835                 840                 845             
Lys Ala Lys Trp Glu Gln Glu Leu Cys Ser Val Arg Leu Pro Leu Asn
    850                 855                 860                 
Gln Glu Glu Glu Lys Arg Arg Asn Val Asp Ile Leu Lys Glu Lys Ile
865                 870                 875                 880 
Arg Pro Glu Glu Gln Leu Arg Lys Lys Leu Glu Val Lys His Gln Leu
                885                 890                 895     
Glu Gln Thr Leu Arg Ile Gln Asp Ile Glu Leu Lys Ser Val Thr Ser
            900                 905                 910         
Asn Leu Asn Gln Val Ser His Thr His Glu Ser Glu Asn Asp Leu Phe
        915                 920                 925             
His Glu Asn Cys Met Leu Lys Lys Glu Ile Ala Met Leu Lys Leu Glu
    930                 935                 940                 
Val Ala Thr Leu Lys His Gln His Gln Val Lys Glu Asn Lys Tyr Phe
945                 950                 955                 960 
Glu Asp Ile Lys Ile Leu Gln Glu Lys Asn Ala Glu Leu Gln Met Thr
                965                 970                 975     
Leu Lys Leu Lys Gln Lys Thr Val Thr Lys Arg Ala Ser Gln Tyr Arg
            980                 985                 990         
Glu Gln Leu Lys Val Leu Thr Ala Glu Asn Thr Met Leu Thr Ser Lys
        995                 1000                1005            
Leu Lys Glu
    1010    


<210> 1558
<211> 433
<212> PRT
<213> Homo sapiens

<400> 1558
Met Pro Cys Gly Lys Gln Gly Asn Leu Gln Val Pro Gly Ser Lys Val
 1               5                  10                  15      
Leu Pro Gly Leu Gly Glu Gly Cys Lys Glu Met Trp Leu Arg Lys Val
            20                  25                  30          
Ile Tyr Gly Gly Glu Val Trp Gly Lys Ser Pro Glu Pro Glu Phe Pro
        35                  40                  45              
Ser Leu Val Asn Leu Cys Gln Ser Trp Lys Ile Asn Asn Leu Met Ser
    50                  55                  60                  
Thr Val His Ser Asp Glu Ala Gly Met Leu Ser Tyr Phe Leu Phe Glu
65                  70                  75                  80  
Glu Leu Met Arg Cys Asp Lys Asp Ser Met Pro Asp Gly Asn Leu Ser
                85                  90                  95      
Glu Glu Glu Lys Leu Phe Leu Ser Tyr Phe Pro Leu His Lys Phe Glu
            100                 105                 110         
Leu Glu Gln Asn Ile Lys Glu Leu Asn Thr Leu Ala Asp Gln Val Asp
        115                 120                 125             
Thr Thr His Glu Leu Leu Thr Lys Thr Ser Leu Val Ala Ser Ser Ser
    130                 135                 140                 
Gly Ala Val Ser Gly Val Met Asn Ile Leu Gly Leu Ala Leu Ala Pro
145                 150                 155                 160 
Val Thr Ala Gly Gly Ser Leu Met Leu Ser Ala Thr Gly Thr Gly Leu
                165                 170                 175     
Gly Ala Ala Ala Ala Ile Thr Asn Ile Val Thr Asn Val Leu Glu Asn
            180                 185                 190         
Arg Ser Asn Ser Ala Ala Arg Asp Lys Ala Ser Arg Leu Gly Pro Leu
        195                 200                 205             
Thr Thr Ser His Glu Ala Phe Gly Gly Ile Asn Trp Ser Glu Ile Glu
    210                 215                 220                 
Ala Ala Gly Phe Cys Val Asn Lys Cys Val Lys Ala Ile Gln Gly Ile
225                 230                 235                 240 
Lys Asp Leu His Ala Tyr Gln Met Ala Lys Ser Asn Ser Gly Phe Met
                245                 250                 255     
Ala Met Val Lys Asn Phe Val Ala Lys Arg His Ile Pro Phe Trp Thr
            260                 265                 270         
Ala Arg Gly Val Gln Arg Ala Phe Glu Gly Thr Thr Leu Ala Met Thr
        275                 280                 285             
Asn Gly Ala Trp Val Met Gly Ala Ala Gly Ala Gly Phe Leu Leu Met
    290                 295                 300                 
Lys Asp Met Ser Ser Phe Leu Gln Ser Trp Lys His Leu Glu Asp Gly
305                 310                 315                 320 
Ala Arg Thr Glu Thr Ala Glu Glu Leu Arg Ala Leu Ala Lys Lys Leu
                325                 330                 335     
Glu Gln Glu Leu Asp Arg Leu Thr Gln His His Arg His Leu Pro Gln
            340                 345                 350         
Lys Ala Ser Gln Thr Cys Ser Ser Ser Arg Gly Arg Ala Val Arg Gly
        355                 360                 365             
Ser Arg Val Val Lys Pro Glu Gly Ser Arg Ser Pro Leu Pro Trp Pro
    370                 375                 380                 
Val Val Glu His Gln Pro Arg Leu Gly Pro Gly Val Ala Leu Arg Thr
385                 390                 395                 400 
Pro Lys Arg Thr Val Ser Ala Pro Arg Met Leu Gly His Gln Pro Ala
                405                 410                 415     
Pro Pro Ala Pro Ala Arg Lys Gly Arg Gln Ala Pro Gly Arg His Arg
            420                 425                 430         
Gln
    


<210> 1559
<211> 56
<212> PRT
<213> Homo sapiens

<400> 1559
Leu Cys Met Pro Leu Pro Pro Arg Ala Ala Glu Leu Ser Trp Gly Asp
 1               5                  10                  15      
Pro Glu Ser His Pro Ala Ala Pro Cys Arg Pro Arg Ser Ser Ser Pro
            20                  25                  30          
Pro Pro Ala Gln Gln Cys Ser Arg Ser Val Trp Pro Leu Val Val Gly
        35                  40                  45              
Arg Arg Lys Gly Leu Asn Arg Gly
    50                  55      


<210> 1560
<211> 144
<212> PRT
<213> Homo sapiens

<400> 1560
Met Asp Ser Glu Glu Glu Glu Glu Val Pro Gln Pro Met Pro Ser Ile
 1               5                  10                  15      
Pro Glu Asp Leu Glu Ser Gln Lys Ala Met Val Ala Phe Phe Asn Ser
            20                  25                  30          
Ala Val Ala Ser Ala Glu Glu Glu Gln Ala Arg Leu Cys Gly Gln Leu
        35                  40                  45              
Lys Glu Cys Thr Ala Ser Ala Trp Leu Ile Cys Trp Pro Arg Pro Arg
    50                  55                  60                  
Arg Asn Leu Arg Gln Gln Pro Gln Pro Gln Glu Leu Gly Val Ile Pro
65                  70                  75                  80  
Cys Val Gly Arg Pro Thr Arg Pro Cys Arg Gly Pro Trp Arg Ser Cys
                85                  90                  95      
Gly Arg Val His Arg Thr Val Pro Glu Pro Glu Gly Ser Ala Glu Gly
            100                 105                 110         
Gly Gly Val His Gln Gln Ala Gly Pro Gly Gln Gly Arg Gly Glu Gly
        115                 120                 125             
Glu Ala Ala Gly Ala Gly Val Ala Cys Gly Arg Leu Gln Gln Val Ala
    130                 135                 140                 


<210> 1561
<211> 379
<212> PRT
<213> Homo sapiens

<400> 1561
Met Glu Gln Leu Ser Ser Ala Asn Thr Arg Phe Ala Leu Asp Leu Phe
 1               5                  10                  15      
Leu Ala Leu Ser Glu Asn Asn Pro Ala Gly Asn Ile Phe Ile Ser Pro
            20                  25                  30          
Phe Ser Ile Ser Ser Ala Met Ala Met Val Phe Leu Gly Thr Arg Gly
        35                  40                  45              
Asn Thr Ala Ala Gln Leu Ser Lys Thr Phe His Phe Asn Thr Val Glu
    50                  55                  60                  
Glu Val His Ser Arg Phe Gln Ser Leu Asn Ala Asp Ile Asn Lys Arg
65                  70                  75                  80  
Gly Ala Ser Tyr Ile Leu Lys Leu Ala Asn Arg Leu Tyr Gly Glu Lys
                85                  90                  95      
Thr Tyr Asn Phe Leu Pro Glu Phe Leu Val Ser Thr Gln Lys Thr Tyr
            100                 105                 110         
Gly Ala Asp Leu Ala Ser Val Asp Phe Gln His Ala Ser Glu Asp Ala
        115                 120                 125             
Arg Lys Thr Ile Asn Gln Trp Val Lys Gly Gln Thr Glu Gly Lys Ile
    130                 135                 140                 
Pro Glu Leu Leu Ala Ser Gly Met Val Asp Asn Met Thr Lys Leu Val
145                 150                 155                 160 
Leu Val Asn Ala Ile Tyr Phe Lys Gly Asn Trp Lys Asp Lys Phe Met
                165                 170                 175     
Lys Glu Ala Thr Thr Asn Ala Pro Phe Arg Leu Asn Lys Lys Asp Arg
            180                 185                 190         
Lys Thr Val Lys Met Met Tyr Gln Lys Lys Lys Phe Ala Tyr Gly Tyr
        195                 200                 205             
Ile Glu Asp Leu Lys Cys Arg Val Leu Glu Leu Pro Tyr Gln Gly Glu
    210                 215                 220                 
Glu Leu Ser Met Val Ile Leu Leu Pro Asp Asp Ile Glu Asp Glu Ser
225                 230                 235                 240 
Thr Gly Leu Lys Lys Ile Glu Glu Gln Leu Thr Leu Glu Lys Leu His
                245                 250                 255     
Glu Trp Thr Lys Pro Glu Asn Leu Asp Phe Ile Glu Val Asn Val Ser
            260                 265                 270         
Leu Pro Arg Phe Lys Leu Glu Glu Ser Tyr Thr Leu Asn Ser Asp Leu
        275                 280                 285             
Ala Arg Leu Gly Val Gln Asp Leu Phe Asn Ser Ser Lys Ala Asp Leu
    290                 295                 300                 
Ser Gly Met Ser Gly Ala Arg Asp Ile Phe Ile Ser Lys Ile Val His
305                 310                 315                 320 
Lys Ser Phe Val Glu Val Asn Glu Glu Gly Thr Glu Ala Ala Ala Ala
                325                 330                 335     
Thr Ala Gly Ile Ala Thr Phe Cys Met Leu Met Pro Glu Glu Asn Phe
            340                 345                 350         
Thr Ala Asp His Pro Phe Leu Phe Phe Ile Arg His Asn Ser Ser Gly
        355                 360                 365             
Ser Ile Leu Phe Leu Gly Arg Phe Ser Ser Pro
    370                 375                 


<210> 1562
<211> 1709
<212> PRT
<213> Homo sapiens

<400> 1562
Met Gly Phe Leu Pro Lys Leu Leu Leu Leu Ala Ser Phe Phe Pro Ala
 1               5                  10                  15      
Gly Gln Ala Ser Trp Gly Val Ser Ser Pro Gln Asp Val Gln Gly Val
            20                  25                  30          
Lys Gly Ser Cys Leu Leu Ile Pro Cys Ile Phe Ser Phe Pro Ala Asp
        35                  40                  45              
Val Glu Val Pro Asp Gly Ile Thr Ala Ile Trp Tyr Tyr Asp Tyr Ser
    50                  55                  60                  
Gly Gln Arg Gln Val Val Ser His Ser Ala Asp Pro Lys Leu Val Glu
65                  70                  75                  80  
Ala Arg Phe Arg Gly Arg Thr Glu Phe Met Gly Asn Pro Glu His Arg
                85                  90                  95      
Val Cys Asn Leu Leu Leu Lys Asp Leu Gln Pro Glu Asp Ser Gly Ser
            100                 105                 110         
Tyr Asn Phe Arg Phe Glu Ile Ser Glu Val Asn Arg Trp Ser Asp Val
        115                 120                 125             
Lys Gly Thr Leu Val Thr Val Thr Glu Glu Pro Arg Val Pro Thr Ile
    130                 135                 140                 
Ala Ser Pro Val Glu Leu Leu Glu Gly Thr Glu Val Asp Phe Asn Cys
145                 150                 155                 160 
Ser Thr Pro Tyr Val Cys Leu Gln Glu Gln Val Arg Leu Gln Trp Gln
                165                 170                 175     
Gly Gln Asp Pro Ala Arg Ser Val Thr Phe Asn Ser Gln Lys Phe Glu
            180                 185                 190         
Pro Thr Gly Val Gly His Leu Glu Thr Leu His Met Ala Met Ser Trp
        195                 200                 205             
Gln Asp His Gly Arg Ile Leu Arg Cys Gln Leu Ser Val Ala Asn His
    210                 215                 220                 
Arg Ala Gln Ser Glu Ile His Leu Gln Val Lys Tyr Ala Pro Lys Gly
225                 230                 235                 240 
Val Lys Ile Leu Leu Ser Pro Ser Gly Arg Asn Ile Leu Pro Gly Glu
                245                 250                 255     
Leu Val Thr Leu Thr Cys Gln Val Asn Ser Ser Tyr Pro Ala Val Ser
            260                 265                 270         
Ser Ile Lys Trp Leu Lys Asp Gly Val Arg Leu Gln Thr Lys Thr Gly
        275                 280                 285             
Val Leu His Leu Pro Gln Ala Ala Trp Ser Asp Ala Gly Val Tyr Thr
    290                 295                 300                 
Cys Gln Ala Glu Asn Gly Val Gly Ser Leu Val Ser Pro Pro Ile Ser
305                 310                 315                 320 
Leu His Ile Phe Met Ala Glu Val Gln Val Ser Pro Ala Gly Pro Ile
                325                 330                 335     
Leu Glu Asn Gln Thr Val Thr Leu Val Cys Asn Thr Pro Asn Glu Ala
            340                 345                 350         
Pro Ser Asp Leu Arg Tyr Ser Trp Tyr Lys Asn His Val Leu Leu Glu
        355                 360                 365             
Asp Ala His Ser His Thr Leu Arg Leu His Leu Ala Thr Arg Ala Asp
    370                 375                 380                 
Thr Gly Phe Tyr Phe Cys Glu Val Gln Asn Val His Gly Ser Glu Arg
385                 390                 395                 400 
Ser Gly Pro Val Ser Val Val Val Asn His Pro Pro Leu Thr Pro Val
                405                 410                 415     
Leu Thr Ala Phe Leu Glu Thr Gln Ala Gly Leu Val Gly Ile Leu His
            420                 425                 430         
Cys Ser Val Val Ser Glu Pro Leu Ala Thr Leu Val Leu Ser His Gly
        435                 440                 445             
Gly His Ile Leu Ala Ser Thr Ser Gly Asp Ser Asp His Ser Pro Arg
    450                 455                 460                 
Phe Ser Gly Thr Ser Gly Pro Asn Ser Leu Arg Leu Glu Ile Arg Asp
465                 470                 475                 480 
Leu Glu Glu Thr Asp Ser Gly Glu Tyr Lys Cys Ser Ala Thr Asn Ser
                485                 490                 495     
Leu Gly Asn Ala Thr Ser Thr Leu Asp Phe His Ala Asn Ala Ala Arg
            500                 505                 510         
Leu Leu Ile Ser Pro Ala Ala Glu Val Val Glu Gly Gln Ala Val Thr
        515                 520                 525             
Leu Ser Cys Arg Ser Gly Leu Ser Pro Thr Pro Asp Ala Arg Phe Ser
    530                 535                 540                 
Trp Tyr Leu Asn Gly Ala Leu Leu His Glu Gly Pro Gly Ser Ser Leu
545                 550                 555                 560 
Leu Leu Pro Ala Ala Ser Ser Thr Asp Ala Gly Ser Tyr His Cys Arg
                565                 570                 575     
Ala Arg Asp Gly His Ser Ala Ser Gly Pro Ser Ser Pro Ala Val Leu
            580                 585                 590         
Thr Val Leu Tyr Pro Pro Arg Gln Pro Thr Phe Thr Thr Arg Leu Asp
        595                 600                 605             
Leu Asp Ala Ala Gly Ala Gly Ala Gly Arg Arg Gly Leu Leu Leu Cys
    610                 615                 620                 
Arg Val Asp Ser Asp Pro Pro Ala Arg Leu Gln Leu Leu His Lys Asp
625                 630                 635                 640 
Arg Val Val Ala Thr Ser Leu Pro Ser Gly Gly Gly Cys Ser Thr Cys
                645                 650                 655     
Gly Gly Cys Ser Pro Arg Met Lys Val Thr Lys Ala Pro Asn Leu Leu
            660                 665                 670         
Arg Val Glu Ile His Asn Pro Leu Leu Glu Glu Glu Gly Leu Tyr Leu
        675                 680                 685             
Cys Glu Ala Ser Asn Ala Leu Gly Asn Ala Ser Thr Ser Ala Thr Phe
    690                 695                 700                 
Asn Gly Gln Ala Thr Val Leu Ala Ile Ala Pro Ser His Thr Leu Gln
705                 710                 715                 720 
Glu Gly Thr Glu Ala Asn Leu Thr Cys Asn Val Ser Arg Glu Ala Ala
                725                 730                 735     
Gly Ser Pro Ala Asn Phe Ser Trp Phe Arg Asn Gly Val Leu Trp Ala
            740                 745                 750         
Gln Gly Pro Leu Glu Thr Val Thr Leu Leu Pro Val Ala Arg Thr Asp
        755                 760                 765             
Ala Ala Leu Tyr Ala Cys Arg Ile Leu Thr Glu Ala Gly Ala Gln Leu
    770                 775                 780                 
Ser Thr Pro Val Leu Leu Ser Val Leu Tyr Pro Pro Asp Arg Pro Lys
785                 790                 795                 800 
Leu Ser Ala Leu Leu Asp Met Gly Gln Gly His Met Ala Leu Phe Ile
                805                 810                 815     
Cys Thr Val Asp Ser Arg Pro Leu Ala Leu Leu Ala Leu Phe His Gly
            820                 825                 830         
Glu His Leu Leu Ala Thr Ser Leu Gly Pro Gln Val Pro Ser His Gly
        835                 840                 845             
Arg Phe Gln Ala Lys Ala Glu Ala Asn Ser Leu Lys Leu Glu Val Arg
    850                 855                 860                 
Glu Leu Gly Leu Gly Asp Ser Gly Ser Tyr Arg Cys Glu Ala Thr Asn
865                 870                 875                 880 
Val Leu Gly Ser Ser Asn Thr Ser Leu Phe Phe Gln Val Arg Gly Ala
                885                 890                 895     
Trp Val Gln Val Ser Pro Ser Pro Glu Leu Gln Glu Gly Gln Ala Val
            900                 905                 910         
Val Leu Ser Cys Gln Val His Thr Gly Val Pro Glu Gly Thr Ser Tyr
        915                 920                 925             
Arg Trp Tyr Arg Asp Gly Gln Pro Leu Gln Glu Ser Thr Ser Ala Thr
    930                 935                 940                 
Leu Arg Phe Ala Ala Ile Thr Leu Thr Gln Ala Gly Ala Tyr His Cys
945                 950                 955                 960 
Gln Ala Gln Ala Pro Gly Ser Ala Thr Thr Ser Leu Ala Ala Pro Ile
                965                 970                 975     
Ser Leu His Val Ser Tyr Ala Pro Arg His Val Thr Leu Thr Thr Leu
            980                 985                 990         
Met Asp Thr Gly Pro Gly Arg Leu Gly Leu Leu Leu Cys Arg Val Asp
        995                 1000                1005            
Ser Asp Pro Pro Ala Gln Leu Arg Leu Leu His Gly Asp Arg Leu Val
    1010                1015                1020                
Ala Ser Thr Leu Gln Gly Val Gly Gly Pro Glu Gly Ser Ser Pro Arg
1025                1030                1035                1040
Leu His Val Ala Val Ala Pro Asn Thr Leu Arg Leu Glu Ile His Gly
                1045                1050                1055    
Ala Met Leu Glu Asp Glu Gly Val Tyr Ile Cys Glu Ala Ser Asn Thr
            1060                1065                1070        
Leu Gly Gln Ala Ser Ala Ser Ala Asp Phe Asp Ala Gln Ala Val Asn
        1075                1080                1085            
Val Gln Val Trp Pro Gly Ala Thr Val Arg Glu Gly Gln Leu Val Asn
    1090                1095                1100                
Leu Thr Cys Leu Val Trp Thr Thr His Pro Ala Gln Leu Thr Tyr Thr
1105                1110                1115                1120
Trp Tyr Gln Asp Gly Gln Gln Arg Leu Asp Ala His Ser Ile Pro Leu
                1125                1130                1135    
Pro Asn Val Thr Val Arg Asp Ala Thr Ser Tyr Arg Cys Gly Val Gly
            1140                1145                1150        
Pro Pro Gly Arg Ala Pro Arg Leu Ser Arg Pro Ile Thr Leu Asp Val
        1155                1160                1165            
Leu Tyr Ala Pro Arg Asn Leu Arg Leu Thr Tyr Leu Leu Glu Ser His
    1170                1175                1180                
Gly Gly Gln Leu Ala Leu Val Leu Cys Thr Val Asp Ser Arg Pro Pro
1185                1190                1195                1200
Ala Gln Leu Ala Leu Ser His Ala Gly Arg Leu Leu Ala Ser Ser Thr
                1205                1210                1215    
Ala Ala Ser Val Pro Asn Thr Leu Arg Leu Glu Leu Arg Gly Pro Gln
            1220                1225                1230        
Pro Arg Asp Glu Gly Phe Tyr Ser Cys Ser Ala Arg Ser Pro Leu Gly
        1235                1240                1245            
Gln Ala Asn Thr Ser Leu Glu Leu Arg Leu Glu Gly Val Arg Val Ile
    1250                1255                1260                
Leu Ala Pro Glu Ala Ala Val Pro Glu Gly Ala Pro Ile Thr Val Thr
1265                1270                1275                1280
Cys Ala Asp Pro Ala Ala His Ala Pro Thr Leu Tyr Thr Trp Tyr His
                1285                1290                1295    
Asn Gly Arg Trp Leu Gln Glu Gly Pro Ala Ala Ser Leu Ser Phe Leu
            1300                1305                1310        
Val Ala Thr Arg Ala His Ala Gly Ala Tyr Ser Cys Gln Ala Gln Asp
        1315                1320                1325            
Ala Gln Gly Thr Arg Ser Ser Arg Pro Ala Ala Leu Gln Val Leu Tyr
    1330                1335                1340                
Ala Pro Gln Asp Ala Val Leu Ser Ser Phe Arg Asp Ser Arg Ala Arg
1345                1350                1355                1360
Ser Met Ala Val Ile Gln Cys Thr Val Asp Ser Glu Pro Pro Ala Glu
                1365                1370                1375    
Leu Ala Leu Ser His Asp Gly Lys Val Leu Ala Thr Ser Ser Gly Val
            1380                1385                1390        
His Ser Leu Ala Ser Gly Thr Gly His Val Gln Val Ala Arg Asn Ala
        1395                1400                1405            
Leu Arg Leu Gln Val Gln Asp Val Pro Ala Gly Asp Asp Thr Tyr Val
    1410                1415                1420                
Cys Thr Ala Gln Asn Leu Leu Gly Ser Ile Ser Thr Ile Gly Arg Leu
1425                1430                1435                1440
Gln Val Glu Gly Ala Arg Val Val Ala Glu Pro Gly Leu Asp Val Pro
                1445                1450                1455    
Glu Gly Ala Ala Leu Asn Leu Ser Cys Arg Leu Leu Gly Gly Pro Gly
            1460                1465                1470        
Pro Val Gly Asn Ser Thr Phe Ala Trp Phe Trp Asn Asp Arg Arg Leu
        1475                1480                1485            
His Ala Glu Pro Val Pro Thr Leu Ala Phe Thr His Val Ala Arg Ala
    1490                1495                1500                
Gln Ala Gly Met Tyr His Cys Leu Ala Glu Leu Pro Thr Gly Ala Ala
1505                1510                1515                1520
Ala Ser Ala Pro Val Met Leu Arg Val Leu Tyr Pro Pro Lys Thr Pro
                1525                1530                1535    
Thr Met Met Val Phe Val Glu Pro Glu Gly Gly Leu Arg Gly Ile Leu
            1540                1545                1550        
Asp Cys Arg Val Asp Ser Glu Pro Leu Ala Ser Leu Thr Leu His Leu
        1555                1560                1565            
Gly Ser Arg Leu Val Ala Ser Ser Gln Pro Gln Gly Ala Pro Ala Glu
    1570                1575                1580                
Pro His Ile His Val Leu Ala Ser Pro Asn Ala Leu Arg Val Asp Ile
1585                1590                1595                1600
Glu Ala Leu Arg Pro Ser Asp Gln Gly Glu Tyr Ile Cys Ser Ala Ser
                1605                1610                1615    
Asn Val Leu Gly Ser Ala Ser Thr Ser Thr Tyr Phe Gly Val Arg Ala
            1620                1625                1630        
Leu His Arg Leu His Gln Phe Gln Gln Leu Leu Trp Val Leu Gly Leu
        1635                1640                1645            
Leu Val Gly Leu Leu Leu Leu Leu Leu Gly Leu Gly Ala Cys Tyr Thr
    1650                1655                1660                
Trp Arg Arg Arg Arg Val Cys Lys Gln Ser Met Gly Glu Asn Ser Val
1665                1670                1675                1680
Glu Met Ala Phe Gln Lys Glu Thr Thr Gln Leu Ile Asp Pro Asp Ala
                1685                1690                1695    
Ala Thr Cys Glu Thr Ser Thr Cys Ala Pro Pro Leu Gly
            1700                1705                


<210> 1563
<211> 441
<212> PRT
<213> Homo sapiens

<400> 1563
Met Ile Ile Pro Ser Leu Glu Glu Leu Asp Ser Leu Lys Tyr Ser Asp
 1               5                  10                  15      
Leu Gln Asn Leu Ala Lys Ser Leu Gly Leu Arg Ala Asn Leu Arg Ala
            20                  25                  30          
Thr Lys Leu Leu Lys Ala Leu Lys Gly Tyr Ile Lys His Glu Ala Arg
        35                  40                  45              
Lys Gly Asn Glu Asn Gln Asp Glu Ser Gln Thr Ser Ala Ser Ser Cys
    50                  55                  60                  
Asp Glu Thr Glu Ile Gln Ile Ser Asn Gln Glu Glu Ala Glu Arg Gln
65                  70                  75                  80  
Pro Leu Gly His Val Thr Lys Thr Arg Arg Arg Cys Lys Thr Val Arg
                85                  90                  95      
Val Asp Pro Asp Ser Gln Gln Asn His Ser Glu Ile Lys Ile Ser Asn
            100                 105                 110         
Pro Thr Glu Phe Gln Asn His Glu Lys Gln Glu Ser Gln Asp Leu Arg
        115                 120                 125             
Ala Thr Ala Lys Val Pro Ser Pro Pro Asp Glu His Gln Glu Ala Glu
    130                 135                 140                 
Asn Ala Val Ser Ser Gly Asn Arg Asp Ser Lys Val Pro Ser Glu Gly
145                 150                 155                 160 
Lys Lys Ser Leu Tyr Thr Asp Glu Ser Ser Lys Pro Gly Lys Asn Lys
                165                 170                 175     
Arg Thr Ala Ile Thr Thr Pro Asn Phe Lys Lys Leu His Glu Ala His
            180                 185                 190         
Phe Lys Glu Met Glu Ser Ile Asp Gln Tyr Ile Glu Arg Lys Lys Lys
        195                 200                 205             
His Phe Glu Glu His Asn Ser Met Asn Glu Leu Lys Gln Gln Pro Ile
    210                 215                 220                 
Asn Lys Gly Gly Val Arg Thr Pro Val Pro Pro Arg Gly Arg Leu Ser
225                 230                 235                 240 
Val Ala Ser Thr Pro Ile Ser Gln Arg Arg Ser Gln Gly Arg Ser Cys
                245                 250                 255     
Gly Pro Ala Ser Gln Ser Thr Leu Gly Leu Lys Gly Ser Leu Lys Arg
            260                 265                 270         
Ser Ala Ile Ser Ala Ala Lys Thr Gly Val Arg Phe Ser Ala Ala Thr
        275                 280                 285             
Lys Asp Asn Glu His Lys Arg Ser Leu Thr Lys Thr Pro Ala Arg Lys
    290                 295                 300                 
Ser Ala His Val Thr Val Ser Gly Gly Thr Pro Lys Gly Glu Ala Val
305                 310                 315                 320 
Leu Gly Thr His Lys Leu Lys Thr Ile Thr Gly Asn Ser Ala Ala Val
                325                 330                 335     
Ile Thr Pro Phe Lys Leu Thr Thr Glu Ala Thr Gln Thr Pro Val Ser
            340                 345                 350         
Asn Lys Lys Pro Val Phe Asp Leu Lys Ala Ser Leu Ser Arg Pro Leu
        355                 360                 365             
Asn Tyr Glu Pro His Lys Gly Lys Leu Lys Pro Trp Gly Gln Ser Lys
    370                 375                 380                 
Glu Asn Asn Tyr Leu Asn Gln His Val Asn Arg Ile Asn Phe Tyr Lys
385                 390                 395                 400 
Lys Thr Tyr Lys Gln Pro His Leu Gln Thr Lys Glu Glu Gln Arg Lys
                405                 410                 415     
Lys Arg Glu Gln Glu Arg Lys Glu Lys Lys Ala Lys Val Leu Gly Met
            420                 425                 430         
Arg Arg Gly Leu Ile Leu Ala Glu Asp
        435                 440     


<210> 1564
<211> 185
<212> PRT
<213> Homo sapiens

<400> 1564
Ala His Phe Arg Met His Thr Gln Ile Lys Asn Gln Thr Ala Ala Leu
 1               5                  10                  15      
Ile Ser Gly Phe Arg Ser Ile Ile Lys Pro Glu Trp Ile Arg Met Phe
            20                  25                  30          
Ser Thr Pro Glu Leu Gln Arg Leu Ile Ser Gly Asp Asn Ala Glu Ile
        35                  40                  45              
Asp Leu Glu Asp Leu Lys Lys His Thr Val Tyr Tyr Gly Gly Phe His
    50                  55                  60                  
Gly Ser His Arg Val Ile Ile Trp Leu Trp Asp Ile Leu Ala Ser Asp
65                  70                  75                  80  
Phe Thr Pro Asp Glu Arg Ala Met Phe Leu Lys Phe Val Thr Ser Cys
                85                  90                  95      
Ser Arg Pro Pro Leu Leu Gly Phe Ala Tyr Leu Lys Pro Pro Phe Ser
            100                 105                 110         
Ile Arg Cys Val Glu Val Ser Asp Asp Gln Asp Thr Gly Asp Thr Leu
        115                 120                 125             
Gly Ser Val Leu Arg Gly Phe Phe Thr Ile Arg Lys Arg Glu Pro Gly
    130                 135                 140                 
Gly Arg Leu Pro Thr Ser Ser Thr Cys Phe Asn Leu Leu Lys Leu Pro
145                 150                 155                 160 
Asn Tyr Ser Lys Lys Ser Val Leu Arg Glu Lys Leu Arg Tyr Ala Ile
                165                 170                 175     
Ser Met Asn Thr Gly Phe Glu Leu Ser
            180                 185 


<210> 1565
<211> 1137
<212> PRT
<213> Homo sapiens

<400> 1565
Met Thr Met Thr Ala Asn Lys Asn Ser Ser Ile Thr His Gly Ala Gly
 1               5                  10                  15      
Gly Thr Lys Ala Pro Arg Gly Thr Leu Ser Arg Ser Gln Ser Val Ser
            20                  25                  30          
Pro Pro Pro Val Leu Ser Pro Pro Arg Ser Pro Ile Tyr Pro Leu Ser
        35                  40                  45              
Asp Ser Glu Thr Ser Ala Cys Arg Tyr Pro Ser His Ser Ser Ser Arg
    50                  55                  60                  
Val Leu Leu Lys Asp Arg His Pro Pro Ala Pro Ser Pro Gln Asn Pro
65                  70                  75                  80  
Gln Asp Pro Ser Pro Asp Thr Ser Pro Pro Thr Cys Pro Phe Lys Thr
                85                  90                  95      
Ala Ser Phe Gly Tyr Leu Asp Arg Ser Pro Ser Ala Cys Lys Arg Asp
            100                 105                 110         
Ala Gln Lys Glu Ser Val Gln Gly Ala Ala Gln Asp Val Ala Gly Val
        115                 120                 125             
Ala Ala Cys Leu Pro Leu Ala Gln Ser Thr Pro Phe Pro Gly Pro Ala
    130                 135                 140                 
Ala Gly Pro Arg Gly Val Leu Leu Thr Arg Thr Gly Thr Arg Ala His
145                 150                 155                 160 
Ser Leu Gly Ile Arg Glu Lys Ile Ser Ala Trp Glu Gly Arg Arg Glu
                165                 170                 175     
Ala Ser Pro Arg Met Ser Met Cys Gly Glu Lys Arg Glu Gly Ser Gly
            180                 185                 190         
Ser Glu Trp Ala Ala Ser Glu Gly Cys Pro Ser Leu Gly Cys Pro Ser
        195                 200                 205             
Val Val Pro Ser Pro Cys Ser Ser Glu Lys Thr Phe Asp Phe Lys Gly
    210                 215                 220                 
Leu Arg Arg Met Ser Arg Thr Phe Ser Glu Cys Ser Tyr Pro Glu Thr
225                 230                 235                 240 
Glu Glu Glu Gly Glu Ala Leu Pro Val Arg Asp Ser Phe Tyr Arg Leu
                245                 250                 255     
Glu Lys Arg Leu Gly Arg Ser Glu Pro Ser Ala Phe Leu Arg Gly His
            260                 265                 270         
Gly Ser Arg Lys Glu Ser Ser Ala Val Leu Ser Arg Ile Gln Lys Ile
        275                 280                 285             
Glu Gln Val Leu Lys Glu Gln Pro Gly Arg Gly Leu Pro Gln Leu Pro
    290                 295                 300                 
Ser Ser Cys Tyr Ser Val Asp Arg Gly Lys Arg Lys Thr Gly Thr Leu
305                 310                 315                 320 
Gly Ser Leu Glu Glu Pro Ala Gly Gly Ala Ser Val Ser Ala Gly Ser
                325                 330                 335     
Arg Ala Val Gly Val Ala Gly Val Ala Gly Glu Ala Gly Pro Pro Pro
            340                 345                 350         
Glu Arg Glu Gly Ser Gly Ser Thr Lys Pro Gly Thr Pro Gly Asn Ser
        355                 360                 365             
Pro Ser Ser Gln Arg Leu Pro Ser Lys Ser Ser Leu Asp Pro Ala Val
    370                 375                 380                 
Asn Pro Val Pro Lys Pro Lys Arg Thr Phe Glu Tyr Glu Ala Glu Lys
385                 390                 395                 400 
Asn Pro Lys Ser Lys Pro Ser Asn Gly Leu Pro Pro Ser Pro Thr Pro
                405                 410                 415     
Ala Ala Pro Pro Pro Leu Pro Ser Thr Pro Ala Pro Pro Val Thr Arg
            420                 425                 430         
Arg Pro Lys Lys Asp Met Arg Gly His Arg Lys Ser Gln Ser Arg Lys
        435                 440                 445             
Ser Phe Glu Phe Glu Asp Ala Ser Ser Leu Gln Ser Leu Tyr Pro Ser
    450                 455                 460                 
Ser Pro Thr Glu Asn Gly Thr Glu Asn Gln Pro Lys Phe Gly Ser Lys
465                 470                 475                 480 
Ser Thr Leu Glu Glu Asn Ala Tyr Glu Asp Ile Val Gly Asp Leu Pro
                485                 490                 495     
Lys Glu Asn Pro Tyr Glu Asp Val Asp Leu Lys Ser Arg Arg Ala Gly
            500                 505                 510         
Arg Lys Ser Gln Gln Leu Ser Glu Asn Ser Leu Asp Ser Leu His Arg
        515                 520                 525             
Met Trp Ser Pro Gln Asp Arg Lys Tyr Asn Ser Pro Pro Thr Gln Leu
    530                 535                 540                 
Ser Leu Lys Pro Asn Ser Gln Ser Leu Arg Ser Gly Asn Trp Ser Glu
545                 550                 555                 560 
Arg Lys Ser His Arg Leu Pro Arg Leu Pro Lys Arg His Ser His Asp
                565                 570                 575     
Asp Met Leu Leu Leu Ala Gln Leu Ser Leu Pro Ser Ser Pro Ser Ser
            580                 585                 590         
Leu Asn Glu Asp Ser Leu Ser Thr Thr Ser Glu Leu Leu Ser Ser Arg
        595                 600                 605             
Arg Ala Arg Arg Ile Pro Lys Leu Val Gln Arg Ile Asn Ser Ile Tyr
    610                 615                 620                 
Asn Ala Lys Arg Gly Lys Lys Arg Leu Lys Lys Leu Ser Met Ser Ser
625                 630                 635                 640 
Ile Glu Thr Ala Ser Leu Arg Asp Glu Asn Ser Glu Ser Glu Ser Asp
                645                 650                 655     
Ser Asp Asp Arg Phe Lys Ala His Thr Gln Arg Leu Val His Ile Gln
            660                 665                 670         
Ser Met Leu Lys Arg Ala Pro Ser Tyr Arg Thr Leu Glu Leu Glu Leu
        675                 680                 685             
Leu Glu Trp Gln Glu Arg Glu Leu Phe Glu Tyr Phe Val Val Val Ser
    690                 695                 700                 
Leu Lys Lys Lys Pro Ser Arg Asn Thr Tyr Leu Pro Glu Val Ser Tyr
705                 710                 715                 720 
Gln Phe Pro Lys Leu Asp Arg Pro Thr Lys Gln Met Arg Glu Ala Glu
                725                 730                 735     
Glu Arg Leu Lys Ala Ile Pro Gln Phe Cys Phe Pro Asp Ala Lys Asp
            740                 745                 750         
Trp Leu Pro Val Ser Glu Tyr Ser Ser Glu Thr Phe Ser Phe Met Leu
        755                 760                 765             
Thr Gly Glu Asp Gly Ser Arg Arg Phe Gly Tyr Cys Arg Arg Leu Leu
    770                 775                 780                 
Pro Ser Gly Lys Gly Pro Arg Leu Pro Glu Val Tyr Cys Val Ile Ser
785                 790                 795                 800 
Arg Leu Gly Cys Phe Gly Leu Phe Ser Lys Val Leu Asp Glu Val Glu
                805                 810                 815     
Arg Arg Arg Gly Ile Ser Ala Ala Leu Val Tyr Pro Phe Met Arg Ser
            820                 825                 830         
Leu Met Glu Ser Pro Phe Pro Ala Pro Gly Lys Thr Ile Lys Val Lys
        835                 840                 845             
Thr Phe Leu Pro Gly Ala Gly Asn Glu Val Leu Glu Leu Arg Arg Pro
    850                 855                 860                 
Met Asp Ser Arg Leu Glu His Val Asp Phe Glu Cys Leu Phe Thr Cys
865                 870                 875                 880 
Leu Ser Val Arg Gln Leu Ile Arg Ile Phe Ala Ser Leu Leu Leu Glu
                885                 890                 895     
Arg Arg Val Ile Phe Val Ala Asp Lys Leu Ser Thr Leu Ser Ser Cys
            900                 905                 910         
Ser His Ala Val Val Ala Leu Leu Tyr Pro Phe Ser Trp Gln His Thr
        915                 920                 925             
Phe Ile Pro Val Leu Pro Ala Ser Met Ile Asp Ile Val Cys Cys Pro
    930                 935                 940                 
Thr Pro Phe Leu Val Gly Leu Leu Ser Ser Ser Leu Pro Lys Leu Lys
945                 950                 955                 960 
Glu Leu Pro Val Glu Glu Ala Leu Met Val Asn Leu Gly Ser Asp Arg
                965                 970                 975     
Phe Ile Arg Gln Met Asp Asp Glu Asp Thr Leu Leu Pro Arg Lys Leu
            980                 985                 990         
Gln Ala Ala Leu Glu Gln Ala Leu Glu Arg Lys Asn Glu Leu Ile Ser
        995                 1000                1005            
Gln Asp Ser Asp Ser Asp Ser Asp Asp Glu Cys Asn Thr Leu Asn Gly
    1010                1015                1020                
Leu Val Ser Glu Val Phe Ile Arg Phe Phe Val Glu Thr Val Gly His
1025                1030                1035                1040
Tyr Ser Leu Phe Leu Thr Gln Ser Glu Lys Gly Glu Arg Ala Phe Gln
                1045                1050                1055    
Arg Glu Ala Phe Arg Lys Ser Val Ala Ser Lys Ser Ile Arg Arg Phe
            1060                1065                1070        
Leu Glu Val Phe Met Glu Ser Gln Met Phe Ala Gly Phe Ile Gln Asp
        1075                1080                1085            
Arg Glu Leu Arg Lys Cys Arg Ala Lys Gly Leu Phe Glu Gln Arg Val
    1090                1095                1100                
Glu Gln Tyr Leu Glu Glu Leu Pro Asp Thr Glu Gln Ser Gly Met Asn
1105                1110                1115                1120
Lys Phe Leu Arg Gly Leu Gly Asn Lys Met Lys Phe Leu His Lys Lys
                1125                1130                1135    
Asn
    


<210> 1566
<211> 875
<212> PRT
<213> Homo sapiens

<400> 1566
Met Gly Lys Thr Ala Asn Ser Pro Gly Ser Gly Ala Arg Pro Asp Pro
 1               5                  10                  15      
Val Arg Ser Phe Asn Arg Trp Lys Lys Lys His Ser His Arg Gln Asn
            20                  25                  30          
Lys Lys Lys Gln Leu Arg Lys Gln Leu Lys Lys Pro Glu Trp Gln Val
        35                  40                  45              
Glu Arg Glu Ser Ile Ser Arg Leu Met Gln Asn Tyr Glu Lys Ile Asn
    50                  55                  60                  
Val Asn Glu Ile Thr Arg Phe Ser Asp Phe Pro Leu Ser Lys Lys Thr
65                  70                  75                  80  
Leu Lys Gly Leu Gln Glu Ala Gln Tyr Arg Leu Val Thr Glu Ile Gln
                85                  90                  95      
Lys Gln Thr Ile Gly Leu Ala Leu Gln Gly Lys Asp Val Leu Gly Ala
            100                 105                 110         
Ala Lys Thr Gly Ser Gly Lys Thr Leu Ala Phe Leu Val Pro Val Leu
        115                 120                 125             
Glu Ala Leu Tyr Arg Leu Gln Trp Thr Ser Thr Asp Gly Leu Gly Val
    130                 135                 140                 
Leu Ile Ile Ser Pro Thr Arg Glu Leu Ala Tyr Gln Thr Phe Glu Val
145                 150                 155                 160 
Leu Arg Lys Val Gly Lys Asn His Asp Phe Ser Ala Gly Leu Ile Ile
                165                 170                 175     
Gly Gly Lys Asp Leu Lys His Glu Ala Glu Arg Ile Asn Asn Ile Asn
            180                 185                 190         
Ile Leu Val Cys Thr Pro Gly Arg Leu Leu Gln His Met Asp Glu Thr
        195                 200                 205             
Val Ser Phe His Ala Thr Asp Leu Gln Met Leu Val Leu Asp Glu Ala
    210                 215                 220                 
Asp Arg Ile Leu Asp Met Gly Phe Ala Asp Thr Met Asn Ala Val Ile
225                 230                 235                 240 
Glu Asn Leu Pro Lys Lys Arg Gln Thr Leu Leu Phe Ser Ala Thr Gln
                245                 250                 255     
Thr Lys Ser Val Lys Asp Leu Ala Arg Leu Ser Leu Lys Asn Pro Glu
            260                 265                 270         
Tyr Val Trp Val His Glu Lys Ala Lys Tyr Ser Thr Pro Ala Thr Leu
        275                 280                 285             
Glu Gln Asn Tyr Ile Val Cys Glu Leu Gln Gln Lys Ile Ser Val Leu
    290                 295                 300                 
Tyr Ser Phe Leu Arg Ser His Leu Lys Lys Lys Ser Ile Val Phe Phe
305                 310                 315                 320 
Ser Ser Cys Lys Glu Val Gln Tyr Leu Tyr Arg Val Phe Cys Arg Leu
                325                 330                 335     
Arg Pro Gly Val Ser Ile Leu Ala Leu His Gly Arg Gln Gln Gln Met
            340                 345                 350         
Arg Arg Met Glu Val Tyr Asn Glu Phe Val Arg Lys Arg Ala Ala Val
        355                 360                 365             
Leu Phe Ala Thr Asp Ile Ala Ala Arg Gly Leu Asp Phe Pro Ala Val
    370                 375                 380                 
Asn Trp Val Leu Gln Phe Asp Cys Pro Glu Asp Ala Asn Thr Tyr Ile
385                 390                 395                 400 
His Arg Ala Gly Arg Thr Ala Arg Tyr Lys Glu Asp Gly Glu Ala Leu
                405                 410                 415     
Leu Ile Leu Leu Pro Ser Glu Lys Ala Met Val Gln Gln Leu Leu Gln
            420                 425                 430         
Lys Lys Val Pro Val Lys Glu Ile Lys Ile Asn Pro Glu Lys Leu Ile
        435                 440                 445             
Asp Val Gln Lys Lys Leu Glu Ser Ile Leu Ala Gln Asp Gln Asp Leu
    450                 455                 460                 
Lys Glu Arg Ala Gln Arg Cys Phe Val Ser Tyr Val Arg Ser Val Tyr
465                 470                 475                 480 
Leu Met Lys Asp Lys Glu Val Phe Asp Val Ser Lys Leu Pro Ile Pro
                485                 490                 495     
Glu Tyr Ala Leu Ser Leu Gly Leu Ala Val Ala Pro Arg Val Arg Phe
            500                 505                 510         
Leu Gln Lys Met Gln Lys Gln Pro Thr Lys Glu Leu Val Arg Ser Gln
        515                 520                 525             
Ala Asp Lys Val Ile Glu Pro Arg Ala Pro Ser Leu Thr Asn Asp Glu
    530                 535                 540                 
Val Glu Glu Phe Arg Ala Tyr Phe Asn Glu Lys Met Ser Ile Leu Gln
545                 550                 555                 560 
Lys Gly Gly Lys Arg Leu Glu Gly Thr Glu His Arg Gln Asp Asn Asp
                565                 570                 575     
Thr Gly Asn Glu Glu Gln Glu Glu Glu Glu Asp Asp Glu Glu Glu Met
            580                 585                 590         
Glu Glu Lys Leu Ala Lys Ala Lys Gly Ser Gln Ala Pro Ser Leu Pro
        595                 600                 605             
Asn Thr Ser Glu Ala Gln Lys Ile Lys Glu Val Pro Thr Gln Phe Leu
    610                 615                 620                 
Asp Arg Asp Glu Glu Glu Glu Asp Ala Asp Phe Leu Lys Val Lys Arg
625                 630                 635                 640 
His Asn Val Phe Gly Leu Asp Leu Lys Asp Glu Lys Thr Leu Gln Lys
                645                 650                 655     
Lys Glu Pro Ser Lys Ser Ser Ile Lys Lys Lys Met Thr Lys Val Ala
            660                 665                 670         
Glu Ala Lys Lys Val Met Lys Arg Asn Phe Lys Val Asn Lys Lys Ile
        675                 680                 685             
Thr Phe Thr Asp Glu Gly Glu Leu Val Gln Gln Trp Pro Gln Met Gln
    690                 695                 700                 
Lys Ser Ala Ile Lys Asp Ala Glu Glu Asp Asp Asp Thr Gly Gly Ile
705                 710                 715                 720 
Asn Leu His Lys Ala Lys Glu Arg Leu Gln Glu Glu Asp Lys Phe Asp
                725                 730                 735     
Lys Glu Glu Tyr Arg Lys Lys Ile Lys Ala Lys His Arg Glu Lys Arg
            740                 745                 750         
Leu Lys Glu Arg Glu Ala Arg Arg Glu Ala Asn Lys Arg Gln Ala Lys
        755                 760                 765             
Ala Lys Asp Glu Glu Glu Ala Phe Leu Asp Trp Ser Asp Asp Asp Asp
    770                 775                 780                 
Asp Asp Asp Asp Gly Phe Asp Pro Ser Thr Leu Pro Asp Pro Asp Lys
785                 790                 795                 800 
Tyr Arg Ser Ser Glu Asp Ser Asp Ser Glu Asp Met Glu Asn Lys Ile
                805                 810                 815     
Ser Asp Thr Lys Lys Lys Gln Gly Met Lys Lys Arg Ser Asn Ser Glu
            820                 825                 830         
Val Glu Asp Val Gly Pro Thr Ser His Asn Arg Lys Lys Ala Arg Trp
        835                 840                 845             
Asp Thr Leu Glu Pro Leu Asp Thr Gly Leu Ser Leu Ala Glu Asp Glu
    850                 855                 860                 
Glu Leu Val Leu His Leu Leu Arg Ser Gln Ser
865                 870                 875 


<210> 1567
<211> 1338
<212> PRT
<213> Homo sapiens

<400> 1567
Met Asp Arg Ala Ser Glu Leu Leu Phe Tyr Val Asn Gly Arg Lys Val
 1               5                  10                  15      
Ile Glu Lys Asn Val Asp Pro Glu Thr Met Leu Leu Pro Tyr Leu Arg
            20                  25                  30          
Lys Lys Leu Arg Leu Thr Gly Thr Lys Tyr Gly Cys Gly Gly Gly Gly
        35                  40                  45              
Cys Gly Ala Cys Thr Val Met Ile Ser Arg Tyr Asn Pro Ile Thr Lys
    50                  55                  60                  
Arg Ile Arg His His Pro Ala Asn Ala Cys Leu Ile Pro Ile Cys Ser
65                  70                  75                  80  
Leu Tyr Gly Ala Ala Val Thr Thr Val Glu Gly Ile Gly Ser Thr His
                85                  90                  95      
Thr Arg Ile His Pro Val Gln Glu Arg Ile Ala Lys Cys His Gly Thr
            100                 105                 110         
Gln Cys Gly Phe Cys Thr Pro Gly Met Val Met Ser Ile Tyr Thr Leu
        115                 120                 125             
Leu Arg Asn His Pro Glu Pro Thr Leu Asp Gln Leu Thr Asp Ala Leu
    130                 135                 140                 
Gly Gly Asn Leu Cys Arg Cys Thr Gly Tyr Arg Pro Ile Ile Asp Ala
145                 150                 155                 160 
Cys Lys Thr Phe Cys Lys Thr Ser Gly Cys Cys Gln Ser Lys Glu Asn
                165                 170                 175     
Gly Val Cys Cys Leu Asp Gln Gly Ile Asn Gly Leu Pro Glu Phe Glu
            180                 185                 190         
Glu Gly Ser Lys Thr Ser Pro Lys Leu Phe Ala Glu Glu Glu Phe Leu
        195                 200                 205             
Pro Leu Asp Pro Thr Gln Glu Leu Ile Phe Pro Pro Glu Leu Met Ile
    210                 215                 220                 
Met Ala Glu Lys Gln Ser Gln Arg Thr Arg Val Phe Gly Ser Glu Arg
225                 230                 235                 240 
Met Met Trp Phe Ser Pro Val Thr Leu Lys Glu Leu Leu Glu Phe Lys
                245                 250                 255     
Phe Lys Tyr Pro Gln Ala Pro Val Ile Met Gly Asn Thr Ser Val Gly
            260                 265                 270         
Pro Glu Val Lys Phe Lys Gly Val Phe His Pro Val Ile Ile Ser Pro
        275                 280                 285             
Asp Arg Ile Glu Glu Leu Ser Val Val Asn His Ala Tyr Asn Gly Leu
    290                 295                 300                 
Thr Leu Gly Ala Gly Leu Ser Leu Ala Gln Val Lys Asp Ile Leu Ala
305                 310                 315                 320 
Asp Val Val Gln Lys Leu Pro Glu Glu Lys Thr Gln Met Tyr His Ala
                325                 330                 335     
Leu Leu Lys His Leu Gly Thr Leu Ala Gly Ser Gln Ile Arg Asn Met
            340                 345                 350         
Ala Ser Leu Gly Gly His Ile Ile Ser Arg His Pro Asp Ser Asp Leu
        355                 360                 365             
Asn Pro Ile Leu Ala Val Gly Asn Cys Thr Leu Asn Leu Leu Ser Lys
    370                 375                 380                 
Glu Gly Lys Arg Gln Ile Pro Leu Asn Glu Gln Phe Leu Ser Lys Cys
385                 390                 395                 400 
Pro Asn Ala Asp Leu Lys Pro Gln Glu Ile Leu Val Ser Val Asn Ile
                405                 410                 415     
Pro Tyr Ser Arg Lys Trp Glu Phe Val Ser Ala Phe Arg Gln Ala Gln
            420                 425                 430         
Arg Gln Glu Asn Ala Leu Ala Ile Val Asn Ser Gly Met Arg Val Phe
        435                 440                 445             
Phe Gly Glu Gly Asp Gly Ile Ile Arg Glu Leu Cys Ile Ser Tyr Gly
    450                 455                 460                 
Gly Val Gly Pro Ala Thr Ile Cys Ala Lys Asn Ser Cys Gln Lys Leu
465                 470                 475                 480 
Ile Gly Arg His Trp Asn Glu Gln Met Leu Asp Ile Ala Cys Arg Leu
                485                 490                 495     
Ile Leu Asn Glu Val Ser Leu Leu Gly Ser Ala Pro Gly Gly Lys Val
            500                 505                 510         
Glu Phe Lys Arg Thr Leu Ile Ile Ser Phe Leu Phe Lys Phe Tyr Leu
        515                 520                 525             
Glu Val Ser Gln Ile Leu Lys Lys Met Asp Pro Val His Tyr Pro Ser
    530                 535                 540                 
Leu Ala Asp Lys Tyr Glu Ser Ala Leu Glu Asp Leu His Ser Lys His
545                 550                 555                 560 
His Cys Ser Thr Leu Lys Tyr Gln Asn Ile Gly Pro Lys Gln His Pro
                565                 570                 575     
Glu Asp Pro Ile Gly His Pro Ile Met His Leu Ser Gly Val Lys His
            580                 585                 590         
Ala Thr Gly Glu Ala Ile Tyr Cys Asp Asp Met Pro Leu Val Asp Gln
        595                 600                 605             
Glu Leu Phe Leu Thr Phe Val Thr Ser Ser Arg Ala His Ala Lys Ile
    610                 615                 620                 
Val Ser Ile Asp Leu Ser Glu Ala Leu Ser Met Pro Gly Val Val Asp
625                 630                 635                 640 
Ile Met Thr Ala Glu His Leu Ser Asp Val Asn Ser Phe Cys Phe Phe
                645                 650                 655     
Thr Glu Ala Glu Lys Phe Leu Ala Thr Asp Lys Val Phe Cys Val Gly
            660                 665                 670         
Gln Leu Val Cys Ala Val Leu Ala Asp Ser Glu Val Gln Ala Lys Arg
        675                 680                 685             
Ala Ala Lys Arg Val Lys Ile Val Tyr Gln Asp Leu Glu Pro Leu Ile
    690                 695                 700                 
Leu Thr Ile Glu Glu Ser Ile Gln His Asn Ser Ser Phe Lys Pro Glu
705                 710                 715                 720 
Arg Lys Leu Glu Tyr Gly Asn Val Asp Glu Ala Phe Lys Val Val Asp
                725                 730                 735     
Gln Ile Leu Glu Gly Glu Ile His Met Gly Gly Gln Glu His Phe Tyr
            740                 745                 750         
Met Glu Thr Gln Ser Met Leu Val Val Pro Lys Gly Glu Asp Gln Glu
        755                 760                 765             
Met Asp Val Tyr Val Ser Thr Gln Phe Pro Lys Tyr Ile Gln Asp Ile
    770                 775                 780                 
Val Ala Ser Thr Leu Lys Leu Pro Ala Asn Lys Val Met Cys His Val
785                 790                 795                 800 
Arg Arg Val Gly Gly Ala Phe Gly Gly Lys Val Leu Lys Thr Gly Ile
                805                 810                 815     
Ile Ala Ala Val Thr Ala Phe Ala Ala Asn Lys His Gly Arg Ala Val
            820                 825                 830         
Arg Cys Val Leu Glu Arg Gly Glu Asp Met Leu Ile Thr Gly Gly Arg
        835                 840                 845             
His Pro Tyr Leu Gly Lys Tyr Lys Ala Gly Phe Met Asn Asp Gly Arg
    850                 855                 860                 
Ile Leu Ala Leu Asp Met Glu His Tyr Ser Asn Ala Gly Ala Ser Leu
865                 870                 875                 880 
Asp Glu Ser Leu Phe Val Ile Glu Met Gly Leu Leu Lys Met Asp Asn
                885                 890                 895     
Ala Tyr Lys Phe Pro Asn Leu Arg Cys Arg Gly Trp Ala Cys Arg Thr
            900                 905                 910         
Asn Leu Pro Ser Asn Thr Ala Phe Arg Gly Phe Gly Phe Pro Gln Ala
        915                 920                 925             
Ala Leu Ile Thr Glu Ser Cys Ile Thr Glu Val Ala Ala Lys Cys Gly
    930                 935                 940                 
Leu Ser Pro Glu Lys Val Arg Ile Ile Asn Met Tyr Lys Glu Ile Asp
945                 950                 955                 960 
Gln Thr Pro Tyr Lys Gln Glu Ile Asn Ala Lys Asn Leu Ile Gln Cys
                965                 970                 975     
Trp Arg Glu Cys Met Ala Met Ser Ser Tyr Ser Leu Arg Lys Val Ala
            980                 985                 990         
Val Glu Lys Phe Asn Ala Glu Asn Tyr Trp Lys Lys Lys Gly Leu Ala
        995                 1000                1005            
Met Val Pro Leu Lys Phe Pro Val Gly Leu Gly Ser Arg Ala Ala Gly
    1010                1015                1020                
Gln Ala Ala Ala Leu Val His Ile Tyr Leu Asp Gly Ser Val Leu Val
1025                1030                1035                1040
Thr His Gly Gly Ile Glu Met Gly Gln Gly Val His Thr Lys Met Ile
                1045                1050                1055    
Gln Val Val Ser Arg Glu Leu Arg Met Pro Met Ser Asn Val His Leu
            1060                1065                1070        
Arg Gly Thr Ser Thr Glu Thr Val Pro Asn Ala Asn Ile Ser Gly Gly
        1075                1080                1085            
Ser Val Val Ala Asp Leu Asn Gly Leu Ala Val Lys Asp Ala Cys Gln
    1090                1095                1100                
Thr Leu Leu Lys Arg Leu Glu Pro Ile Ile Ser Lys Asn Pro Lys Gly
1105                1110                1115                1120
Thr Trp Lys Asp Trp Ala Gln Thr Ala Phe Asp Glu Ser Ile Asn Leu
                1125                1130                1135    
Ser Ala Val Gly Tyr Phe Arg Gly Tyr Glu Ser Asp Met Asn Trp Glu
            1140                1145                1150        
Lys Gly Glu Gly Gln Pro Phe Glu Tyr Phe Val Tyr Gly Ala Ala Cys
        1155                1160                1165            
Ser Glu Val Glu Ile Asp Cys Leu Thr Gly Asp His Lys Asn Ile Arg
    1170                1175                1180                
Thr Asp Ile Val Met Asp Val Gly Cys Ser Ile Asn Pro Ala Ile Asp
1185                1190                1195                1200
Ile Gly Gln Ile Glu Gly Ala Phe Ile Gln Gly Met Gly Leu Tyr Thr
                1205                1210                1215    
Ile Glu Glu Leu Asn Tyr Ser Pro Gln Gly Ile Leu His Thr Arg Gly
            1220                1225                1230        
Pro Asp Gln Tyr Lys Ile Pro Ala Ile Cys Asp Met Pro Thr Glu Leu
        1235                1240                1245            
His Ile Ala Leu Leu Pro Pro Ser Gln Asn Ser Asn Thr Leu Tyr Ser
    1250                1255                1260                
Ser Lys Gly Leu Gly Glu Ser Gly Val Phe Leu Gly Cys Ser Val Phe
1265                1270                1275                1280
Phe Ala Ile His Asp Ala Val Ser Ala Ala Arg Gln Glu Arg Gly Leu
                1285                1290                1295    
His Gly Pro Leu Thr Leu Asn Ser Pro Leu Thr Pro Glu Lys Ile Arg
            1300                1305                1310        
Met Ala Cys Glu Asp Lys Phe Thr Lys Met Ile Pro Arg Asp Glu Pro
        1315                1320                1325            
Gly Ser Tyr Val Pro Trp Asn Val Pro Ile
    1330                1335            


<210> 1568
<211> 725
<212> PRT
<213> Homo sapiens

<400> 1568
Met Ala Ala Ala Ser Ala Val Ser Val Leu Leu Val Ala Ala Glu Arg
 1               5                  10                  15      
Asn Arg Trp His Arg Leu Pro Ser Leu Leu Leu Pro Pro Arg Thr Trp
            20                  25                  30          
Val Trp Arg Gln Arg Thr Met Lys Tyr Thr Thr Ala Thr Gly Arg Asn
        35                  40                  45              
Ile Thr Lys Val Leu Ile Ala Asn Arg Gly Glu Ile Ala Cys Arg Val
    50                  55                  60                  
Met Arg Thr Ala Lys Lys Leu Gly Val Gln Thr Val Ala Val Tyr Ser
65                  70                  75                  80  
Glu Ala Asp Arg Asn Ser Met His Val Asp Met Ala Asp Glu Ala Tyr
                85                  90                  95      
Ser Ile Gly Pro Ala Pro Ser Gln Gln Ser Tyr Leu Ser Met Glu Lys
            100                 105                 110         
Ile Ile Gln Val Ala Lys Thr Ser Ala Ala Gln Ala Ile His Pro Gly
        115                 120                 125             
Cys Gly Phe Leu Ser Glu Asn Met Glu Phe Ala Glu Leu Cys Lys Gln
    130                 135                 140                 
Glu Gly Ile Ile Phe Ile Gly Pro Pro Pro Ser Ala Ile Arg Asp Met
145                 150                 155                 160 
Gly Ile Lys Ser Thr Ser Lys Ser Ile Met Ala Ala Ala Gly Val Pro
                165                 170                 175     
Val Val Glu Gly Tyr His Gly Glu Asp Gln Ser Asp Gln Cys Leu Lys
            180                 185                 190         
Glu His Ala Arg Arg Ile Gly Tyr Pro Val Met Ile Lys Ala Val Arg
        195                 200                 205             
Gly Gly Gly Gly Lys Gly Met Arg Ile Val Arg Ser Glu Gln Glu Phe
    210                 215                 220                 
Gln Glu Gln Leu Glu Ser Ala Arg Arg Glu Ala Lys Lys Ser Phe Asn
225                 230                 235                 240 
Asp Asp Ala Met Leu Ile Glu Lys Phe Val Asp Thr Pro Arg His Val
                245                 250                 255     
Glu Val Gln Val Phe Gly Asp His His Gly Asn Ala Val Tyr Leu Phe
            260                 265                 270         
Glu Arg Asp Cys Ser Val Gln Arg Arg His Gln Lys Ile Ile Glu Glu
        275                 280                 285             
Ala Pro Ala Pro Gly Ile Lys Ser Glu Val Arg Lys Lys Leu Gly Glu
    290                 295                 300                 
Ala Ala Val Arg Ala Ala Lys Ala Val Asn Tyr Val Gly Ala Gly Thr
305                 310                 315                 320 
Val Glu Phe Ile Met Asp Ser Lys His Asn Phe Cys Phe Met Glu Met
                325                 330                 335     
Asn Thr Arg Leu Gln Val Glu His Pro Val Thr Glu Met Ile Thr Gly
            340                 345                 350         
Thr Asp Leu Val Glu Trp Gln Leu Arg Ile Ala Ala Gly Glu Lys Ile
        355                 360                 365             
Pro Leu Ser Gln Glu Glu Ile Thr Leu Gln Gly His Ala Phe Glu Ala
    370                 375                 380                 
Arg Ile Tyr Ala Glu Asp Pro Ser Asn Asn Phe Met Pro Val Ala Gly
385                 390                 395                 400 
Pro Leu Val His Leu Ser Thr Pro Arg Ala Asp Pro Ser Thr Arg Ile
                405                 410                 415     
Glu Thr Gly Val Arg Gln Gly Asp Glu Val Ser Val His Tyr Asp Pro
            420                 425                 430         
Met Ile Ala Lys Leu Val Val Trp Ala Ala Asp Arg Gln Ala Ala Leu
        435                 440                 445             
Thr Lys Leu Arg Tyr Ser Leu Arg Gln Tyr Asn Ile Val Gly Leu Pro
    450                 455                 460                 
Thr Asn Ile Asp Phe Leu Leu Asn Leu Ser Gly His Pro Glu Phe Glu
465                 470                 475                 480 
Ala Gly Asn Val His Thr Asp Phe Ile Pro Gln His His Lys Gln Leu
                485                 490                 495     
Leu Leu Ser Arg Lys Ala Ala Ala Lys Glu Ser Leu Cys Gln Ala Ala
            500                 505                 510         
Leu Gly Leu Ile Leu Lys Glu Lys Ala Met Thr Asp Thr Phe Thr Leu
        515                 520                 525             
Gln Ala His Asp Gln Phe Ser Pro Phe Ser Ser Ser Ser Gly Arg Arg
    530                 535                 540                 
Leu Asn Ile Ser Tyr Thr Arg Asn Met Thr Leu Lys Asp Gly Lys Asn
545                 550                 555                 560 
Asn Val Ala Ile Ala Val Thr Tyr Asn His Asp Gly Ser Tyr Ser Met
                565                 570                 575     
Gln Ile Glu Asp Lys Thr Phe Gln Val Leu Gly Asn Leu Tyr Ser Glu
            580                 585                 590         
Gly Asp Cys Thr Tyr Leu Lys Cys Ser Val Asn Gly Val Ala Ser Lys
        595                 600                 605             
Ala Lys Leu Ile Ile Leu Glu Asn Thr Ile Tyr Leu Phe Ser Lys Glu
    610                 615                 620                 
Gly Ser Ile Glu Ile Asp Ile Pro Val Pro Lys Tyr Leu Ser Ser Val
625                 630                 635                 640 
Ser Ser Gln Glu Thr Gln Gly Gly Pro Leu Ala Pro Met Thr Gly Thr
                645                 650                 655     
Ile Glu Lys Val Phe Val Lys Ala Gly Asp Lys Val Lys Ala Gly Asp
            660                 665                 670         
Ser Leu Met Val Met Ile Ala Met Lys Met Glu His Thr Ile Lys Ser
        675                 680                 685             
Pro Lys Asp Gly Thr Val Lys Lys Val Phe Tyr Arg Glu Gly Ala Gln
    690                 695                 700                 
Ala Asn Arg His Thr Pro Leu Val Glu Phe Glu Glu Glu Glu Ser Asp
705                 710                 715                 720 
Lys Arg Glu Ser Glu
                725 


<210> 1569
<211> 333
<212> PRT
<213> Homo sapiens

<400> 1569
Met Cys Arg Gly Gly Arg Met Phe Ala Pro Thr Lys Thr Trp Arg Arg
 1               5                  10                  15      
Trp His Arg Arg Val Asn Thr Thr Gln Lys Arg Tyr Ala Ile Cys Ser
            20                  25                  30          
Ala Leu Ala Ala Ser Ala Leu Pro Ala Leu Val Met Ser Lys Gly His
        35                  40                  45              
Arg Ile Glu Glu Val Pro Glu Leu Pro Leu Val Val Glu Asp Lys Val
    50                  55                  60                  
Glu Gly Tyr Lys Lys Thr Lys Glu Ala Val Leu Leu Leu Lys Lys Leu
65                  70                  75                  80  
Lys Ala Trp Asn Asp Ile Lys Lys Val Tyr Ala Ser Gln Arg Met Arg
                85                  90                  95      
Ala Gly Lys Gly Lys Met Arg Asn Arg Arg Arg Ile Gln Arg Arg Gly
            100                 105                 110         
Pro Cys Ile Ile Tyr Asn Glu Asp Asn Gly Ile Ile Lys Ala Phe Arg
        115                 120                 125             
Asn Ile Pro Gly Ile Thr Leu Leu Asn Val Ser Lys Leu Asn Ile Leu
    130                 135                 140                 
Lys Leu Ala Pro Gly Gly His Val Gly Arg Phe Cys Ile Trp Thr Glu
145                 150                 155                 160 
Ser Ala Phe Arg Lys Leu Asp Glu Leu Tyr Gly Thr Trp Arg Lys Ala
                165                 170                 175     
Ala Ser Leu Lys Ser Asn Tyr Asn Leu Pro Met His Lys Met Ile Asn
            180                 185                 190         
Thr Asp Leu Ser Arg Ile Leu Lys Ser Pro Glu Ile Gln Arg Ala Leu
        195                 200                 205             
Arg Ala Pro Arg Lys Lys Ile His Arg Arg Val Leu Lys Lys Asn Pro
    210                 215                 220                 
Leu Lys Asn Leu Arg Ile Met Leu Lys Leu Asn Pro Tyr Ala Lys Thr
225                 230                 235                 240 
Met Arg Arg Asn Thr Ile Leu Arg Gln Ala Arg Asn His Lys Leu Arg
                245                 250                 255     
Val Asp Lys Ala Ala Ala Ala Ala Ala Ala Leu Gln Ala Lys Ser Asp
            260                 265                 270         
Glu Lys Ala Ala Val Ala Gly Lys Lys Pro Val Val Gly Lys Lys Gly
        275                 280                 285             
Lys Lys Ala Ala Val Gly Val Lys Lys Gln Lys Lys Pro Leu Val Gly
    290                 295                 300                 
Lys Lys Ala Ala Ala Thr Lys Lys Pro Ala Pro Glu Lys Lys Pro Ala
305                 310                 315                 320 
Glu Lys Lys Pro Thr Thr Glu Glu Lys Lys Pro Ala Ala
                325                 330             


<210> 1570
<211> 175
<212> PRT
<213> Homo sapiens

<400> 1570
Met Ala Ala Val Ser Met Ser Val Val Leu Arg Gln Thr Leu Trp Arg
 1               5                  10                  15      
Arg Arg Ala Val Ala Val Ala Ala Leu Ser Val Ser Arg Val Pro Thr
            20                  25                  30          
Arg Ser Leu Arg Thr Ser Ser Trp Arg Leu Ala Gln Asp Gln Thr Gln
        35                  40                  45              
Asp Thr Gln Leu Ile Thr Val Asp Glu Lys Leu Asp Ile Thr Thr Leu
    50                  55                  60                  
Thr Gly Val Pro Glu Glu His Ile Lys Thr Arg Lys Val Arg Ile Phe
65                  70                  75                  80  
Val Pro Ala Arg Asn Asn Met Gln Ser Gly Val Asn Asn Thr Lys Lys
                85                  90                  95      
Trp Lys Met Glu Phe Asp Thr Arg Glu Arg Trp Glu Asn Pro Leu Met
            100                 105                 110         
Gly Trp Ala Ser Thr Ala Asp Pro Leu Ser Asn Met Val Leu Thr Phe
        115                 120                 125             
Ser Thr Lys Glu Asp Ala Val Ser Phe Ala Glu Lys Asn Gly Trp Ser
    130                 135                 140                 
Tyr Asp Ile Glu Glu Arg Lys Val Pro Lys Pro Lys Ser Lys Ser Tyr
145                 150                 155                 160 
Gly Ala Asn Phe Ser Trp Asn Lys Arg Thr Arg Val Ser Thr Lys
                165                 170                 175 


<210> 1571
<211> 159
<212> PRT
<213> Homo sapiens

<400> 1571
Met Val Pro Ser Ala Gly Gln Leu Ala Leu Phe Ala Leu Gly Ile Val
 1               5                  10                  15      
Leu Ala Ala Cys Gln Ala Leu Glu Asn Ser Thr Ser Pro Leu Ser Asp
            20                  25                  30          
Pro Pro Val Ala Ala Ala Val Val Ser His Phe Asn Asp Cys Pro Asp
        35                  40                  45              
Ser His Thr Gln Phe Cys Phe His Gly Thr Cys Arg Phe Leu Val Gln
    50                  55                  60                  
Glu Asp Lys Pro Ala Cys Val Cys His Ser Gly Tyr Val Gly Ala Arg
65                  70                  75                  80  
Cys Glu His Ala Asp Leu Leu Ala Val Val Ala Ala Ser Gln Lys Lys
                85                  90                  95      
Gln Ala Ile Thr Ala Leu Val Val Val Ser Ile Val Ala Leu Ala Val
            100                 105                 110         
Leu Ile Ile Thr Cys Val Leu Ile His Cys Cys Gln Val Arg Lys His
        115                 120                 125             
Cys Glu Trp Cys Arg Ala Leu Ile Cys Arg His Glu Lys Pro Ser Ala
    130                 135                 140                 
Leu Leu Lys Gly Arg Thr Ala Cys Cys His Ser Glu Thr Val Val
145                 150                 155                 


<210> 1572
<211> 258
<212> PRT
<213> Homo sapiens

<400> 1572
Met Ala Ala Ser Val Leu Asn Thr Val Leu Arg Arg Leu Pro Met Leu
 1               5                  10                  15      
Ser Leu Phe Arg Gly Ser His Arg Val Gln Val Pro Leu Gln Thr Leu
            20                  25                  30          
Cys Thr Lys Ala Pro Ser Glu Glu Asp Ser Leu Ser Ser Val Pro Ile
        35                  40                  45              
Ser Pro Tyr Lys Asp Glu Pro Trp Lys Tyr Leu Glu Ser Glu Glu Tyr
    50                  55                  60                  
Gln Glu Arg Tyr Gly Ser Arg Pro Val Trp Ala Asp Tyr Arg Arg Asn
65                  70                  75                  80  
His Lys Gly Gly Val Pro Pro Gln Arg Thr Arg Lys Thr Cys Ile Arg
                85                  90                  95      
Arg Asn Lys Val Val Gly Asn Pro Cys Pro Ile Cys Arg Asp His Lys
            100                 105                 110         
Leu His Val Asp Phe Arg Asn Val Lys Leu Leu Glu Gln Phe Val Cys
        115                 120                 125             
Ala His Thr Gly Ile Ile Phe Tyr Ala Pro Tyr Thr Gly Val Cys Val
    130                 135                 140                 
Lys Gln His Lys Arg Leu Thr Gln Ala Ile Gln Lys Ala Arg Asp His
145                 150                 155                 160 
Gly Leu Leu Ile Tyr His Ile Pro Gln Val Glu Pro Arg Asp Leu Asp
                165                 170                 175     
Phe Ser Thr Ser His Gly Ala Val Ser Ala Thr Pro Pro Ala Pro Thr
            180                 185                 190         
Leu Val Ser Ser Asp Pro Trp Tyr Pro Trp Tyr Asn Trp Lys Gln Pro
        195                 200                 205             
Pro Glu Arg Glu Leu Ser Arg Leu Arg Arg Leu Tyr Gln Gly His Leu
    210                 215                 220                 
Gln Glu Glu Ser Gly Pro Pro Pro Glu Ser Met Pro Lys Met Pro Pro
225                 230                 235                 240 
Arg Thr Pro Ala Glu Ala Ser Ser Thr Gly Gln Thr Gly Pro Gln Ser
                245                 250                 255     
Ala Leu
        


<210> 1573
<211> 316
<212> PRT
<213> Homo sapiens

<400> 1573
Met Ala Ser Arg Leu Leu Leu Asn Asn Gly Ala Lys Met Pro Ile Leu
 1               5                  10                  15      
Gly Leu Gly Thr Trp Lys Ser Pro Pro Gly Gln Val Thr Glu Ala Val
            20                  25                  30          
Lys Val Ala Ile Asp Val Gly Tyr Arg His Ile Asp Cys Ala His Val
        35                  40                  45              
Tyr Gln Asn Glu Asn Glu Val Gly Val Ala Ile Gln Glu Lys Leu Arg
    50                  55                  60                  
Glu Gln Val Val Lys Arg Glu Glu Leu Phe Ile Val Ser Lys Leu Trp
65                  70                  75                  80  
Cys Thr Tyr His Glu Lys Gly Leu Val Lys Gly Ala Cys Gln Lys Thr
                85                  90                  95      
Leu Ser Asp Leu Lys Leu Asp Tyr Leu Asp Leu Tyr Leu Ile His Trp
            100                 105                 110         
Pro Thr Gly Phe Lys Pro Gly Lys Glu Phe Phe Pro Leu Asp Glu Ser
        115                 120                 125             
Gly Asn Val Val Pro Ser Asp Thr Asn Ile Leu Asp Thr Arg Ala Ala
    130                 135                 140                 
Met Glu Glu Leu Val Asp Glu Gly Leu Val Lys Ala Ile Gly Ile Ser
145                 150                 155                 160 
Asn Phe Asn His Leu Gln Val Glu Met Ile Leu Asn Lys Pro Gly Leu
                165                 170                 175     
Lys Tyr Lys Pro Ala Val Asn Gln Ile Glu Cys His Pro Tyr Leu Thr
            180                 185                 190         
Gln Glu Lys Leu Ile Gln Tyr Cys Gln Ser Lys Gly Ile Val Val Thr
        195                 200                 205             
Ala Tyr Ser Pro Leu Gly Ser Pro Asp Arg Pro Trp Ala Lys Pro Glu
    210                 215                 220                 
Asp Pro Ser Leu Leu Glu Asp Pro Arg Ile Lys Ala Ile Ala Ala Lys
225                 230                 235                 240 
His Asn Lys Thr Thr Ala Gln Val Leu Ile Arg Phe Pro Met Gln Arg
                245                 250                 255     
Asn Leu Val Val Ile Pro Lys Ser Val Thr Pro Glu Arg Ile Ala Glu
            260                 265                 270         
Asn Phe Lys Val Phe Asp Phe Glu Leu Ser Ser Gln Asp Met Thr Thr
        275                 280                 285             
Leu Leu Ser Tyr Asn Arg Asn Trp Arg Val Cys Ala Leu Leu Ser Cys
    290                 295                 300                 
Thr Ser His Lys Asp Tyr Pro Phe His Glu Glu Phe
305                 310                 315     


<210> 1574
<211> 338
<212> PRT
<213> Homo sapiens

<400> 1574
Met Asn Ser Leu Ser Glu Ala Asn Thr Lys Phe Met Phe Asp Leu Phe
 1               5                  10                  15      
Gln Gln Phe Arg Lys Ser Lys Glu Asn Asn Ile Phe Tyr Ser Pro Ile
            20                  25                  30          
Ser Ile Thr Ser Ala Leu Gly Met Val Leu Leu Gly Ala Lys Asp Asn
        35                  40                  45              
Thr Ala Gln Gln Ile Lys Lys Val Leu His Phe Asp Gln Val Thr Glu
    50                  55                  60                  
Asn Thr Thr Gly Lys Ala Ala Thr Tyr His Val Asp Arg Ser Gly Asn
65                  70                  75                  80  
Val His His Gln Phe Gln Lys Leu Leu Thr Glu Phe Asn Lys Ser Thr
                85                  90                  95      
Asp Ala Tyr Glu Leu Lys Ile Ala Asn Lys Leu Phe Gly Glu Lys Thr
            100                 105                 110         
Tyr Leu Phe Leu Gln Glu Tyr Leu Asp Ala Ile Lys Lys Phe Tyr Gln
        115                 120                 125             
Thr Ser Val Glu Ser Val Asp Phe Ala Asn Ala Pro Glu Glu Ser Arg
    130                 135                 140                 
Lys Lys Ile Asn Ser Trp Val Glu Ser Gln Thr Asn Glu Lys Ile Lys
145                 150                 155                 160 
Asn Leu Ile Pro Glu Gly Asn Ile Gly Ser Asn Thr Thr Leu Val Leu
                165                 170                 175     
Val Asn Ala Ile Tyr Phe Lys Gly Gln Trp Glu Lys Lys Phe Asn Lys
            180                 185                 190         
Glu Asp Thr Lys Glu Glu Lys Phe Trp Pro Asn Lys Leu Glu Glu Lys
        195                 200                 205             
Leu Thr Ala Glu Lys Leu Met Glu Trp Thr Ser Leu Gln Asn Met Arg
    210                 215                 220                 
Glu Thr Arg Val Asp Leu His Leu Pro Arg Phe Lys Val Glu Glu Ser
225                 230                 235                 240 
Tyr Asp Leu Lys Asp Thr Leu Arg Thr Met Gly Met Val Asp Ile Phe
                245                 250                 255     
Asn Gly Asp Ala Asp Leu Ser Gly Met Thr Gly Ser Arg Gly Leu Val
            260                 265                 270         
Leu Ser Gly Val Leu His Lys Ala Phe Val Glu Val Thr Glu Glu Gly
        275                 280                 285             
Ala Glu Ala Ala Ala Ala Thr Ala Val Val Gly Phe Gly Ser Ser Pro
    290                 295                 300                 
Ala Ser Thr Asn Glu Glu Phe His Cys Asn His Pro Phe Leu Phe Phe
305                 310                 315                 320 
Ile Arg Gln Asn Lys Thr Asn Ser Ile Leu Phe Tyr Gly Arg Phe Ser
                325                 330                 335     
Ser Pro
        


<210> 1575
<211> 122
<212> PRT
<213> Homo sapiens

<400> 1575
Met Lys Leu Leu Thr Gly Leu Val Phe Cys Ser Leu Val Leu Ser Val
 1               5                  10                  15      
Ser Ser Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala
            20                  25                  30          
Arg Asp Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile
        35                  40                  45              
Gly Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys
    50                  55                  60                  
Arg Gly Pro Gly Gly Ala Trp Ala Ala Glu Val Ile Ser Asn Ala Arg
65                  70                  75                  80  
Glu Asn Ile Gln Arg Leu Thr Gly His Gly Ala Glu Asp Ser Leu Ala
                85                  90                  95      
Asp Gln Ala Ala Asn Lys Trp Gly Arg Ser Gly Arg Asp Pro Asn His
            100                 105                 110         
Phe Arg Pro Ala Gly Leu Pro Glu Lys Tyr
        115                 120         


<210> 1576
<211> 355
<212> PRT
<213> Homo sapiens

<400> 1576
Met Glu Pro His Leu Leu Gly Leu Leu Leu Gly Leu Leu Leu Gly Gly
 1               5                  10                  15      
Thr Arg Val Leu Ala Gly Tyr Pro Ile Trp Trp Ser Leu Ala Leu Gly
            20                  25                  30          
Gln Gln Tyr Thr Ser Leu Gly Ser Gln Pro Leu Leu Cys Gly Ser Ile
        35                  40                  45              
Pro Gly Leu Val Pro Lys Gln Leu Arg Phe Cys Arg Asn Tyr Ile Glu
    50                  55                  60                  
Ile Met Pro Ser Val Ala Glu Gly Val Lys Leu Gly Ile Gln Glu Cys
65                  70                  75                  80  
Gln His Gln Phe Arg Gly Arg Arg Trp Asn Cys Thr Thr Ile Asp Asp
                85                  90                  95      
Ser Leu Ala Ile Phe Gly Pro Val Leu Asp Lys Ala Thr Arg Glu Ser
            100                 105                 110         
Ala Phe Val His Ala Ile Ala Ser Ala Gly Val Ala Phe Ala Val Thr
        115                 120                 125             
Arg Ser Cys Ala Glu Gly Thr Ser Thr Ile Cys Gly Cys Asp Ser His
    130                 135                 140                 
His Lys Gly Pro Pro Gly Glu Gly Trp Lys Trp Gly Gly Cys Ser Glu
145                 150                 155                 160 
Asp Ala Asp Phe Gly Val Leu Val Ser Arg Glu Phe Ala Asp Ala Arg
                165                 170                 175     
Glu Asn Arg Pro Asp Ala Arg Ser Ala Met Asn Lys His Asn Asn Glu
            180                 185                 190         
Ala Gly Arg Thr Thr Ile Leu Asp His Met His Leu Lys Cys Lys Cys
        195                 200                 205             
His Gly Leu Ser Gly Ser Cys Glu Val Lys Thr Cys Trp Trp Ala Gln
    210                 215                 220                 
Pro Asp Phe Arg Ala Ile Gly Asp Phe Leu Lys Asp Lys Tyr Asp Ser
225                 230                 235                 240 
Ala Ser Glu Met Val Val Glu Lys His Arg Glu Ser Arg Gly Trp Val
                245                 250                 255     
Glu Thr Leu Arg Ala Lys Tyr Ser Leu Phe Lys Pro Pro Thr Glu Arg
            260                 265                 270         
Asp Leu Val Tyr Tyr Glu Asn Ser Pro Asn Phe Cys Glu Pro Asn Pro
        275                 280                 285             
Glu Thr Gly Ser Phe Gly Thr Arg Asp Arg Thr Cys Asn Val Thr Ser
    290                 295                 300                 
His Gly Ile Asp Gly Cys Asp Leu Leu Cys Cys Gly Arg Gly His Asn
305                 310                 315                 320 
Thr Arg Thr Glu Lys Arg Lys Glu Lys Cys His Cys Ile Phe His Trp
                325                 330                 335     
Cys Cys Tyr Val Ser Cys Gln Glu Cys Ile Arg Ile Tyr Asp Val His
            340                 345                 350         
Thr Cys Lys
        355 


<210> 1577
<211> 444
<212> PRT
<213> Homo sapiens

<400> 1577
Met Cys Pro Gly Ser Val Pro Ala Pro Pro Val Gly Gln Arg Thr Leu
 1               5                  10                  15      
Arg Pro Trp Arg Arg Glu Met Gln Arg Val Leu Ser Ala Gln Met Leu
            20                  25                  30          
Ala Val Thr Gly Pro Arg Asn Ser Gln Arg Arg Thr Ser Arg Cys Ser
        35                  40                  45              
Asp Glu Glu Arg Pro Ser Thr Ser Arg Ala Cys Val Val Asn Gly Pro
    50                  55                  60                  
Asp Gly Thr Arg Ser Ala Phe Ser Phe Arg Thr Leu Pro Gln Gly Gly
65                  70                  75                  80  
Ser Ser Gly Pro Ala His Asp Glu Arg Thr Asn Gly Ser Gly Ser Gly
                85                  90                  95      
Ala Thr Gly Glu Asp Arg Arg Gly Ser Ser Gln Pro Glu Ser Cys Asp
            100                 105                 110         
Val Gln Ser Asn Glu Asp Tyr Pro Arg Arg Pro Leu Thr Arg Ala Arg
        115                 120                 125             
Ser Arg Leu Ser His Val Leu Leu Val Ser Glu Ser Glu Val Ala Lys
    130                 135                 140                 
Thr Lys Pro Arg His Ala Met Lys Arg Lys Arg Thr Ala Asp Lys Ser
145                 150                 155                 160 
Thr Ser Thr Ser Asp Pro Val Ile Glu Asp Asp His Val Gln Val Leu
                165                 170                 175     
Val Leu Lys Ser Lys Asn Leu Val Gly Val Thr Met Thr Asn Cys Gly
            180                 185                 190         
Ile Thr Asp Leu Val Leu Lys Asp Cys Pro Lys Met Met Phe Ile His
        195                 200                 205             
Ala Thr Arg Cys Arg Val Leu Lys His Leu Lys Val Glu Asn Ala Pro
    210                 215                 220                 
Ile Val Asn Arg Phe Asp Tyr Ala Gln Cys Lys Lys Leu Asn Met Asp
225                 230                 235                 240 
Gln Val Leu Asp Gln Ile Leu Arg Met Pro Pro Glu Arg Asn Arg Ile
                245                 250                 255     
Ile Tyr Leu Arg Pro Met Gln Gln Val Asp Thr Leu Thr Leu Glu Gln
            260                 265                 270         
Lys Leu Phe Ser Gly Pro Tyr Pro Tyr His Ile Cys Ile Ile His Glu
        275                 280                 285             
Phe Ser Asn Pro Pro Asn Val Arg Asn Lys Val Arg Ile Arg Ser Trp
    290                 295                 300                 
Met Asp Thr Ile Ala Asn Ile Asn Gln Glu Leu Ile Lys Tyr Glu Phe
305                 310                 315                 320 
Phe Pro Glu Ala Thr Arg Ser Glu Glu Asp Leu Lys Lys Tyr Pro Lys
                325                 330                 335     
Tyr Pro Trp Gly Arg Glu Ile Tyr Thr Leu Glu Gly Val Val Asp Gly
            340                 345                 350         
Ala Pro Tyr Ser Met Ile Ser Asp Phe Pro Trp Leu Arg Ser Leu Arg
        355                 360                 365             
Ala Ala Glu Pro Asn Ser Phe Ala Arg Tyr Asp Phe Glu Asp Asp Glu
    370                 375                 380                 
Glu Ser Thr Ile Tyr Ala Pro Arg Arg Lys Gly Gln Leu Ser Ala Asp
385                 390                 395                 400 
Ile Cys Met Glu Thr Ile Gly Glu Glu Ile Ser Glu Met Arg Gln Met
                405                 410                 415     
Lys Lys Gly Val Phe Gln Arg Val Val Ala Ile Phe Ile His Tyr Cys
            420                 425                 430         
Asp Val Asn Gly Glu Pro Val Glu Asp Asp Tyr Ile
        435                 440                 


<210> 1578
<211> 651
<212> PRT
<213> Homo sapiens

<400> 1578
Met Leu Arg Leu Gln Met Thr Asp Gly His Ile Ser Cys Thr Ala Val
 1               5                  10                  15      
Glu Phe Ser Tyr Met Ser Lys Ile Ser Leu Asn Thr Pro Pro Gly Thr
            20                  25                  30          
Lys Val Lys Leu Ser Gly Ile Val Asp Ile Lys Asn Gly Phe Leu Leu
        35                  40                  45              
Leu Asn Asp Ser Asn Thr Thr Val Leu Gly Gly Glu Val Glu His Leu
    50                  55                  60                  
Ile Glu Lys Trp Glu Leu Gln Arg Ser Leu Ser Lys His Asn Arg Ser
65                  70                  75                  80  
Asn Ile Gly Thr Glu Gly Gly Pro Pro Pro Phe Val Pro Phe Gly Gln
                85                  90                  95      
Lys Cys Val Ser His Val Gln Val Asp Ser Arg Glu Leu Asp Arg Arg
            100                 105                 110         
Lys Thr Leu Gln Val Thr Met Pro Val Lys Pro Thr Asn Asp Asn Asp
        115                 120                 125             
Glu Phe Glu Lys Gln Arg Thr Ala Ala Ile Ala Glu Val Ala Lys Ser
    130                 135                 140                 
Lys Glu Thr Lys Thr Phe Gly Gly Gly Gly Gly Gly Ala Arg Ser Asn
145                 150                 155                 160 
Leu Asn Met Asn Ala Ala Gly Asn Arg Asn Arg Glu Val Leu Gln Lys
                165                 170                 175     
Glu Lys Ser Thr Lys Ser Glu Gly Lys His Glu Gly Val Tyr Arg Glu
            180                 185                 190         
Leu Val Asp Glu Lys Ala Leu Lys His Ile Thr Glu Met Gly Phe Ser
        195                 200                 205             
Lys Glu Ala Ser Arg Gln Ala Leu Met Asp Asn Gly Asn Asn Leu Glu
    210                 215                 220                 
Ala Ala Leu Asn Val Leu Leu Thr Ser Asn Lys Gln Lys Pro Val Met
225                 230                 235                 240 
Gly Pro Pro Leu Arg Gly Arg Gly Lys Gly Arg Gly Arg Ile Arg Ser
                245                 250                 255     
Glu Asp Glu Glu Asp Leu Gly Asn Ala Arg Pro Ser Ala Pro Ser Thr
            260                 265                 270         
Leu Phe Asp Phe Leu Glu Ser Lys Met Gly Thr Leu Asn Val Glu Glu
        275                 280                 285             
Pro Lys Ser Gln Pro Gln Gln Leu His Gln Gly Gln Tyr Arg Ser Ser
    290                 295                 300                 
Asn Thr Glu Gln Asn Gly Val Lys Asp Asn Asn His Leu Arg His Pro
305                 310                 315                 320 
Pro Arg Asn Asp Thr Arg Gln Pro Arg Asn Glu Lys Pro Pro Arg Phe
                325                 330                 335     
Gln Arg Asp Ser Gln Asn Ser Lys Ser Val Leu Glu Gly Ser Gly Leu
            340                 345                 350         
Pro Arg Asn Arg Gly Ser Glu Arg Pro Ser Thr Ser Ser Val Ser Glu
        355                 360                 365             
Val Trp Ala Glu Asp Arg Ile Lys Cys Asp Arg Pro Tyr Ser Arg Tyr
    370                 375                 380                 
Asp Arg Thr Lys Asp Thr Ser Tyr Pro Leu Gly Ser Gln His Ser Asp
385                 390                 395                 400 
Gly Ala Phe Lys Lys Arg Asp Asn Ser Met Gln Ser Arg Ser Gly Lys
                405                 410                 415     
Gly Pro Ser Phe Ala Glu Ala Lys Glu Asn Pro Leu Pro Gln Gly Ser
            420                 425                 430         
Val Asp Tyr Asn Asn Gln Lys Arg Gly Lys Arg Glu Ser Gln Thr Ser
        435                 440                 445             
Ile Pro Asp Tyr Phe Tyr Asp Arg Lys Ser Gln Thr Ile Asn Asn Glu
    450                 455                 460                 
Ala Phe Ser Gly Ile Lys Ile Glu Lys His Phe Asn Val Asn Thr Asp
465                 470                 475                 480 
Tyr Gln Asn Pro Val Arg Ser Asn Ser Phe Ile Gly Val Pro Asn Gly
                485                 490                 495     
Glu Val Glu Met Pro Leu Lys Gly Arg Arg Ile Gly Pro Ile Lys Pro
            500                 505                 510         
Ala Gly Pro Val Thr Ala Val Pro Cys Asp Asp Lys Ile Phe Tyr Asn
        515                 520                 525             
Ser Gly Pro Lys Arg Arg Ser Gly Pro Ile Lys Pro Glu Lys Ile Leu
    530                 535                 540                 
Glu Ser Ser Ile Pro Met Glu Tyr Ala Lys Met Trp Lys Pro Gly Asp
545                 550                 555                 560 
Glu Cys Phe Ala Leu Tyr Trp Glu Asp Asn Lys Phe Tyr Arg Ala Glu
                565                 570                 575     
Val Glu Ala Leu His Ser Ser Gly Met Thr Ala Val Val Lys Phe Ile
            580                 585                 590         
Asp Tyr Gly Asn Tyr Glu Glu Val Leu Leu Ser Asn Ile Lys Pro Ile
        595                 600                 605             
Gln Thr Glu Ala Trp Glu Glu Glu Gly Thr Tyr Asp Gln Thr Leu Glu
    610                 615                 620                 
Phe Arg Arg Gly Gly Asp Gly Gln Pro Arg Arg Ser Thr Arg Pro Thr
625                 630                 635                 640 
Gln Gln Phe Tyr Gln Pro Pro Arg Ala Arg Asn
                645                 650     


<210> 1579
<211> 453
<212> PRT
<213> Homo sapiens

<400> 1579
Met Ala Gly Ala Ala Ala Gly Gly Arg Gly Gly Gly Ala Trp Gly Pro
 1               5                  10                  15      
Gly Arg Gly Gly Ala Gly Gly Leu Arg Arg Gly Cys Ser Pro Pro Ala
            20                  25                  30          
Pro Ala Gly Ser Pro Arg Ala Gly Leu Gln Pro Leu Arg Ala Thr Ile
        35                  40                  45              
Pro Phe Gln Leu Gln Gln Pro His Gln Arg Arg Asp Gly Gly Gly Arg
    50                  55                  60                  
Ala Ala Ser Val Pro Cys Ser Val Ala Pro Glu Lys Ser Val Cys Arg
65                  70                  75                  80  
Pro Gln Pro Leu Gln Val Arg Arg Thr Phe Ser Leu Asp Thr Ile Leu
                85                  90                  95      
Ser Ser Tyr Leu Leu Gly Gln Trp Pro Arg Asp Ala Asp Gly Ala Phe
            100                 105                 110         
Thr Cys Cys Thr Asn Asp Lys Ala Thr Gln Thr Pro Leu Ser Trp Gln
        115                 120                 125             
Glu Leu Glu Gly Glu Arg Ala Ser Ser Cys Ala His Lys Arg Ser Ala
    130                 135                 140                 
Ser Trp Gly Ser Thr Asp His Arg Lys Glu Ile Ser Lys Leu Lys Gln
145                 150                 155                 160 
Gln Leu Gln Arg Thr Lys Leu Ser Arg Ser Gly Lys Glu Lys Glu Arg
                165                 170                 175     
Gly Ser Pro Leu Leu Gly Asp His Ala Val Arg Gly Ala Leu Arg Ala
            180                 185                 190         
Ser Pro Pro Ser Phe Pro Ser Gly Ser Pro Val Leu Arg Leu Ser Pro
        195                 200                 205             
Cys Leu His Arg Ser Leu Glu Gly Leu Asn Gln Glu Leu Glu Glu Val
    210                 215                 220                 
Phe Val Lys Glu Gln Gly Glu Glu Glu Leu Leu Arg Ile Leu Asp Ile
225                 230                 235                 240 
Pro Asp Gly His Arg Ala Pro Ala Pro Pro Gln Ser Gly Ser Cys Asp
                245                 250                 255     
His Pro Leu Leu Leu Leu Glu Pro Gly Asn Leu Ala Ser Ser Pro Ser
            260                 265                 270         
Met Ser Leu Ala Ser Pro Gln Pro Cys Gly Leu Ala Ser His Glu Glu
        275                 280                 285             
His Arg Gly Ala Ala Glu Glu Leu Ala Ser Thr Pro Asn Asp Lys Ala
    290                 295                 300                 
Ser Ser Pro Gly His Pro Ala Phe Leu Glu Asp Gly Ser Pro Ser Pro
305                 310                 315                 320 
Val Leu Ala Phe Ala Ala Ser Pro Arg Pro Asn His Ser Tyr Ile Phe
                325                 330                 335     
Lys Arg Glu Pro Pro Glu Gly Cys Glu Lys Val Arg Val Phe Glu Glu
            340                 345                 350         
Ala Thr Ser Pro Gly Pro Asp Leu Ala Phe Leu Thr Ser Cys Pro Asp
        355                 360                 365             
Lys Asn Lys Val His Phe Asn Pro Thr Gly Ser Ala Phe Cys Pro Val
    370                 375                 380                 
Asn Leu Met Lys Pro Leu Phe Pro Gly Met Gly Phe Ile Phe Arg Asn
385                 390                 395                 400 
Cys Pro Ser Asn Pro Gly Ser Pro Leu Pro Pro Ala Ser Pro Arg Pro
                405                 410                 415     
Pro Pro Arg Lys Asp Pro Glu Ala Ser Lys Ala Ser Pro Leu Pro Phe
            420                 425                 430         
Glu Pro Trp Gln Arg Thr Pro Pro Ser Glu Glu Pro Val Leu Phe Gln
        435                 440                 445             
Ser Ser Leu Met Val
    450             


<210> 1580
<211> 707
<212> PRT
<213> Homo sapiens

<400> 1580
Met Leu Gly Ser Leu Val Leu Arg Arg Lys Ala Leu Ala Pro Arg Leu
 1               5                  10                  15      
Leu Leu Arg Leu Leu Arg Ser Pro Thr Leu Arg Gly His Gly Gly Ala
            20                  25                  30          
Ser Gly Arg Asn Val Thr Thr Gly Ser Leu Gly Glu Pro Gln Trp Leu
        35                  40                  45              
Arg Val Ala Thr Gly Gly Arg Pro Gly Thr Ser Pro Ala Leu Phe Ser
    50                  55                  60                  
Gly Arg Gly Ala Ala Thr Gly Gly Arg Gln Gly Gly Arg Phe Asp Thr
65                  70                  75                  80  
Lys Cys Leu Ala Ala Ala Thr Trp Gly Arg Leu Pro Gly Pro Glu Glu
                85                  90                  95      
Thr Leu Pro Gly Gln Asp Ser Trp Asn Gly Val Pro Ser Arg Ala Gly
            100                 105                 110         
Leu Gly Met Cys Ala Leu Ala Ala Ala Leu Val Val His Cys Tyr Ser
        115                 120                 125             
Lys Ser Pro Ser Asn Lys Asp Ala Ala Leu Leu Glu Ala Ala Arg Ala
    130                 135                 140                 
Asn Asn Met Gln Glu Val Ser Arg Leu Leu Ser Glu Gly Ala Asp Val
145                 150                 155                 160 
Asn Ala Lys His Arg Leu Gly Trp Thr Ala Leu Met Val Ala Ala Ile
                165                 170                 175     
Asn Arg Asn Asn Ser Val Val Gln Val Leu Leu Ala Ala Gly Ala Asp
            180                 185                 190         
Pro Asn Leu Gly Asp Asp Phe Ser Ser Val Tyr Lys Thr Ala Lys Glu
        195                 200                 205             
Gln Gly Ile His Ser Leu Glu Asp Gly Gly Gln Asp Gly Ala Ser Arg
    210                 215                 220                 
His Ile Thr Asn Gln Trp Thr Ser Ala Leu Glu Phe Arg Arg Trp Leu
225                 230                 235                 240 
Gly Leu Pro Ala Gly Val Leu Ile Thr Arg Glu Asp Asp Phe Asn Asn
                245                 250                 255     
Arg Leu Asn Asn Arg Ala Ser Phe Lys Gly Cys Thr Ala Leu His Tyr
            260                 265                 270         
Ala Val Leu Ala Asp Asp Tyr Arg Thr Val Lys Glu Leu Leu Asp Gly
        275                 280                 285             
Gly Ala Asn Pro Leu Gln Arg Asn Glu Met Gly His Thr Pro Leu Asp
    290                 295                 300                 
Tyr Ala Arg Glu Gly Glu Val Met Lys Leu Leu Arg Thr Ser Glu Ala
305                 310                 315                 320 
Lys Tyr Gln Glu Lys Gln Arg Lys Arg Glu Ala Glu Glu Arg Arg Arg
                325                 330                 335     
Phe Pro Leu Glu Gln Arg Leu Lys Glu His Ile Ile Gly Gln Glu Ser
            340                 345                 350         
Ala Ile Ala Thr Val Gly Ala Ala Ile Arg Arg Lys Glu Asn Gly Trp
        355                 360                 365             
Tyr Asp Glu Glu His Pro Leu Val Phe Leu Phe Leu Gly Ser Ser Gly
    370                 375                 380                 
Ile Gly Lys Thr Glu Leu Ala Lys Gln Thr Ala Lys Tyr Met His Lys
385                 390                 395                 400 
Asp Ala Lys Lys Gly Phe Ile Arg Leu Asp Met Ser Glu Phe Gln Glu
                405                 410                 415     
Arg His Glu Val Ala Lys Phe Ile Gly Ser Pro Pro Gly Tyr Val Gly
            420                 425                 430         
His Glu Glu Gly Gly Gln Leu Thr Lys Lys Leu Lys Gln Cys Pro Asn
        435                 440                 445             
Ala Val Val Leu Phe Asp Glu Val Asp Lys Ala His Pro Asp Val Leu
    450                 455                 460                 
Thr Ile Met Leu Gln Leu Phe Asp Glu Gly Arg Leu Thr Asp Gly Lys
465                 470                 475                 480 
Gly Lys Thr Ile Asp Cys Lys Asp Ala Ile Phe Ile Met Thr Ser Asn
                485                 490                 495     
Val Ala Ser Asp Glu Ile Ala Gln His Ala Leu Gln Leu Arg Gln Glu
            500                 505                 510         
Ala Leu Glu Met Ser Arg Asn Arg Ile Ala Glu Asn Leu Gly Asp Val
        515                 520                 525             
Gln Ile Ser Asp Lys Ile Thr Ile Ser Lys Asn Phe Lys Glu Asn Val
    530                 535                 540                 
Ile Arg Pro Ile Leu Lys Ala His Phe Arg Arg Asp Glu Phe Leu Gly
545                 550                 555                 560 
Arg Ile Asn Glu Ile Val Tyr Phe Leu Pro Phe Cys His Ser Glu Leu
                565                 570                 575     
Ile Gln Leu Val Asn Lys Glu Leu Asn Phe Trp Ala Lys Arg Ala Lys
            580                 585                 590         
Gln Arg His Asn Ile Thr Leu Leu Trp Asp Arg Glu Val Ala Asp Val
        595                 600                 605             
Leu Val Asp Gly Tyr Asn Val His Tyr Gly Ala Arg Ser Ile Lys His
    610                 615                 620                 
Glu Val Glu Arg Arg Val Val Asn Gln Leu Ala Ala Ala Tyr Glu Gln
625                 630                 635                 640 
Asp Leu Leu Pro Gly Gly Cys Thr Leu Arg Ile Thr Val Glu Asp Ser
                645                 650                 655     
Asp Lys Gln Leu Leu Lys Ser Pro Glu Leu Pro Ser Pro Gln Ala Glu
            660                 665                 670         
Lys Arg Leu Pro Lys Leu Arg Leu Glu Ile Ile Asp Lys Asp Ser Lys
        675                 680                 685             
Thr Arg Arg Leu Asp Ile Arg Ala Pro Leu His Pro Glu Lys Val Cys
    690                 695                 700                 
Asn Thr Ile
705         


<210> 1581
<211> 515
<212> PRT
<213> Homo sapiens

<400> 1581
Gly Thr Arg Lys His Pro Ala Thr Lys Asp Leu Ala Ala Ala Ala Ala
 1               5                  10                  15      
Gln Gly Pro Gln Leu Pro Pro Pro Gln Ala Gln Pro Gln Pro Ser Gly
            20                  25                  30          
Thr Gly Gly Gly Val Ser Gly Gln Asp Arg Tyr Asp Arg Ala Thr Ser
        35                  40                  45              
Ser Gly Arg Leu Pro Leu Pro Ser Pro Ala Leu Glu Tyr Thr Leu Gly
    50                  55                  60                  
Ser Arg Leu Ala Asn Gly Leu Gly Arg Glu Glu Ala Val Ala Glu Gly
65                  70                  75                  80  
Ala Arg Arg Ala Leu Leu Gly Ser Met Pro Gly Leu Met Pro Pro Gly
                85                  90                  95      
Leu Leu Ala Ala Ala Val Ser Gly Leu Gly Ser Arg Gly Leu Thr Leu
            100                 105                 110         
Ala Pro Gly Leu Ser Pro Ala Arg Pro Leu Phe Gly Ser Asp Phe Glu
        115                 120                 125             
Lys Glu Lys Gln Gln Arg Asn Ala Asp Cys Leu Ala Glu Leu Asn Glu
    130                 135                 140                 
Ala Met Arg Gly Arg Ala Glu Glu Trp His Gly Arg Pro Lys Ala Val
145                 150                 155                 160 
Arg Glu Gln Leu Leu Ala Leu Ser Ala Cys Ala Pro Phe Asn Val Arg
                165                 170                 175     
Phe Lys Lys Asp His Gly Leu Val Gly Arg Val Phe Ala Phe Asp Ala
            180                 185                 190         
Thr Ala Arg Pro Pro Gly Tyr Glu Phe Glu Leu Lys Leu Phe Thr Glu
        195                 200                 205             
Tyr Pro Cys Gly Ser Gly Asn Val Tyr Ala Gly Val Leu Ala Val Ala
    210                 215                 220                 
Arg Gln Met Phe His Asp Ala Leu Arg Glu Pro Gly Lys Ala Leu Ala
225                 230                 235                 240 
Ser Ser Gly Phe Lys Tyr Leu Glu Tyr Glu Arg Arg His Gly Ser Gly
                245                 250                 255     
Glu Trp Arg Gln Leu Gly Glu Leu Leu Thr Asp Gly Val Arg Ser Phe
            260                 265                 270         
Arg Glu Pro Ala Pro Ala Glu Ala Leu Pro Gln Gln Tyr Pro Glu Pro
        275                 280                 285             
Ala Pro Ala Ala Leu Cys Gly Pro Pro Pro Arg Ala Pro Ser Arg Asn
    290                 295                 300                 
Leu Ala Pro Thr Pro Arg Arg Arg Lys Ala Ser Pro Glu Pro Glu Gly
305                 310                 315                 320 
Glu Ala Ala Gly Lys Met Thr Thr Glu Glu Gln Gln Gln Arg His Trp
                325                 330                 335     
Val Ala Pro Gly Gly Pro Tyr Ser Ala Glu Thr Pro Gly Val Pro Ser
            340                 345                 350         
Pro Ile Ala Ala Leu Lys Asn Val Ala Glu Ala Leu Gly His Ser Pro
        355                 360                 365             
Lys Asp Pro Gly Gly Gly Gly Gly Pro Val Arg Ala Gly Gly Ala Ser
    370                 375                 380                 
Pro Ala Ala Ser Ser Thr Ala Gln Pro Pro Thr Gln His Arg Leu Val
385                 390                 395                 400 
Ala Arg Asn Gly Glu Ala Glu Val Ser Pro Thr Ala Gly Ala Glu Ala
                405                 410                 415     
Val Ser Gly Gly Gly Ser Gly Thr Gly Ala Thr Pro Gly Ala Pro Leu
            420                 425                 430         
Cys Cys Thr Leu Cys Arg Glu Arg Leu Glu Asp Thr His Phe Val Gln
        435                 440                 445             
Cys Pro Ser Val Pro Gly His Lys Phe Cys Phe Pro Cys Ser Arg Glu
    450                 455                 460                 
Phe Ile Lys Ala Gln Gly Pro Ala Gly Glu Val Tyr Cys Pro Ser Gly
465                 470                 475                 480 
Asp Lys Cys Pro Leu Val Gly Ser Ser Val Pro Trp Ala Phe Met Gln
                485                 490                 495     
Gly Glu Ile Ala Thr Ile Leu Ala Gly Asp Ile Lys Val Lys Lys Glu
            500                 505                 510         
Arg Asp Pro
        515 


<210> 1582
<211> 821
<212> PRT
<213> Homo sapiens

<400> 1582
His Glu Gly Thr Ser Ser Pro Leu Pro Ala Pro Lys Lys Pro Thr Gly
 1               5                  10                  15      
Val Asp Leu Leu Thr Pro Gly Ser Arg Ala Pro Glu Leu Lys Gly Arg
            20                  25                  30          
Ala Arg Gly Lys Pro Ser Leu Leu Ala Ala Ala Arg Pro Met Arg Ala
        35                  40                  45              
Ile Leu Pro Ala Pro Val Asn Val Gly Arg Gly Ser Ser Met Gly Leu
    50                  55                  60                  
Pro Arg Ala Arg Gln Ala Phe Ser Leu Ser Asp Lys Thr Pro Ser Val
65                  70                  75                  80  
Arg Thr Cys Gly Leu Lys Pro Ser Thr Leu Lys Gln Leu Gly Gln Pro
                85                  90                  95      
Ile Gln Gln Pro Ser Gly Pro Gly Glu Val Lys Leu Pro Ser Gly Pro
            100                 105                 110         
Ser Asn Arg Thr Ser Gln Val Lys Val Val Glu Val Lys Pro Asp Met
        115                 120                 125             
Phe Pro Pro Tyr Lys Tyr Ser Cys Thr Val Thr Leu Asp Leu Gly Leu
    130                 135                 140                 
Ala Thr Ser Arg Gly Arg Gly Lys Cys Lys Asn Pro Ser Cys Ser Tyr
145                 150                 155                 160 
Val Tyr Thr Asn Arg His Lys Pro Arg Ile Cys Pro Ser Cys Gly Val
                165                 170                 175     
Asn Leu Ala Lys Asp Arg Thr Glu Lys Thr Thr Lys Ala Ile Glu Val
            180                 185                 190         
Ser Ser Pro Leu Pro Asp Val Leu Asn Ala Thr Glu Pro Leu Ser Thr
        195                 200                 205             
Ala Gln Arg Glu Ile Gln Arg Gln Ser Thr Leu Gln Leu Leu Arg Lys
    210                 215                 220                 
Val Leu Gln Ile Pro Glu Asn Glu Ser Glu Leu Ala Glu Val Phe Ala
225                 230                 235                 240 
Leu Ile His Glu Leu Asn Ser Ser Arg Leu Ile Leu Ser Asn Val Ser
                245                 250                 255     
Glu Glu Thr Val Thr Ile Glu Gln Thr Ser Trp Ser Asn Tyr Tyr Glu
            260                 265                 270         
Ser Pro Ser Thr Gln Cys Leu Leu Cys Ser Ser Pro Leu Phe Lys Gly
        275                 280                 285             
Gly Gln Asn Ser Leu Ala Gly Pro Gln Glu Cys Trp Leu Leu Thr Ala
    290                 295                 300                 
Ser Arg Leu Gln Thr Val Thr Ala Gln Val Lys Met Cys Leu Asn Pro
305                 310                 315                 320 
His Cys Leu Ala Leu His Ser Phe Ile Asp Ile Tyr Thr Gly Leu Phe
                325                 330                 335     
Asn Val Gly Asn Lys Leu Leu Val Ser Leu Asp Leu Leu Phe Ala Ile
            340                 345                 350         
Arg Asn Gln Ile Lys Leu Gly Glu Asp Pro Arg Val Ser Ile Asn Val
        355                 360                 365             
Val Leu Lys Ser Val Gln Glu Gln Thr Glu Lys Thr Leu Thr Ser Glu
    370                 375                 380                 
Glu Leu Ser Gln Leu Gln Glu Leu Leu Cys Asn Gly Tyr Trp Ala Phe
385                 390                 395                 400 
Glu Cys Leu Thr Val Arg Asp Tyr Asn Asp Met Ile Cys Gly Ile Cys
                405                 410                 415     
Gly Val Ala Pro Lys Val Glu Met Ala Gln Arg Ser Glu Gln Asn Val
            420                 425                 430         
Leu Ala Leu Lys Ser Val Glu Phe Thr Trp Pro Glu Phe Leu Gly Ser
        435                 440                 445             
Asn Glu Val Asn Val Glu Asp Phe Trp Ala Thr Met Glu Thr Glu Val
    450                 455                 460                 
Ile Glu Gln Val Ala Phe Pro Ala Ser Ile Pro Ile Thr Lys Phe Asp
465                 470                 475                 480 
Ala Ser Val Ile Ala Pro Phe Phe Pro Pro Leu Met Arg Gly Ala Val
                485                 490                 495     
Val Val Asn Thr Glu Lys Asp Lys Asn Leu Asp Val Gln Pro Val Pro
            500                 505                 510         
Gly Ser Gly Ser Ala Leu Val Arg Leu Leu Gln Glu Gly Thr Cys Lys
        515                 520                 525             
Leu Asp Glu Ile Gly Ser Tyr Ser Glu Glu Lys Leu Gln His Leu Leu
    530                 535                 540                 
Arg Gln Cys Gly Ile Pro Phe Gly Ala Glu Asp Ser Lys Asp Gln Leu
545                 550                 555                 560 
Cys Phe Ser Leu Leu Ala Leu Tyr Glu Ser Val Gln Asn Gly Ala Arg
                565                 570                 575     
Ala Ile Arg Pro Pro Arg His Phe Thr Gly Gly Lys Ile Tyr Lys Val
            580                 585                 590         
Cys Pro His Gln Val Val Cys Gly Ser Lys Tyr Leu Val Arg Gly Glu
        595                 600                 605             
Ser Ala Arg Asp His Val Asp Leu Leu Ala Ser Ser Arg His Trp Pro
    610                 615                 620                 
Pro Val Tyr Val Val Asp Met Ala Thr Ser Val Ala Leu Cys Ala Asp
625                 630                 635                 640 
Leu Cys Tyr Pro Glu Leu Thr Asn Gln Met Trp Gly Arg Asn Gln Gly
                645                 650                 655     
Cys Phe Ser Ser Pro Thr Glu Pro Pro Val Ser Val Ser Cys Pro Glu
            660                 665                 670         
Leu Leu Asp Gln His Tyr Thr Val Asp Met Thr Glu Thr Glu His Ser
        675                 680                 685             
Ile Gln His Pro Val Thr Lys Thr Ala Thr Arg Arg Ile Val His Ala
    690                 695                 700                 
Gly Leu Gln Pro Asn Pro Gly Asp Pro Ser Ala Gly His His Ser Leu
705                 710                 715                 720 
Ala Leu Cys Pro Glu Leu Ala Pro Tyr Ala Thr Ile Leu Ala Ser Ile
                725                 730                 735     
Val Asp Ser Lys Pro Asn Gly Val Arg Gln Arg Pro Ile Ala Phe Asp
            740                 745                 750         
Asn Ala Thr His Tyr Tyr Leu Tyr Asn Arg Leu Met Asp Phe Leu Thr
        755                 760                 765             
Ser Arg Glu Ile Val Asn Arg Gln Ile His Asp Ile Val Gln Ser Cys
    770                 775                 780                 
Gln Pro Gly Glu Val Val Ile Arg Asp Thr Leu Tyr Arg Leu Gly Val
785                 790                 795                 800 
Ala Gln Ile Lys Thr Glu Thr Glu Glu Glu Gly Glu Glu Glu Glu Val
                805                 810                 815     
Ala Ala Val Ala Glu
            820     


<210> 1583
<211> 256
<212> PRT
<213> Homo sapiens

<400> 1583
Met Leu Ser Arg Val Val Leu Ser Ala Ala Ala Thr Ala Ala Pro Ser
 1               5                  10                  15      
Leu Lys Asn Ala Ala Phe Leu Gly Pro Gly Val Leu Gln Ala Thr Arg
            20                  25                  30          
Thr Phe His Thr Gly Gln Pro His Leu Val Pro Val Pro Pro Leu Pro
        35                  40                  45              
Glu Tyr Gly Gly Lys Val Arg Tyr Gly Leu Ile Pro Glu Glu Phe Phe
    50                  55                  60                  
Gln Phe Leu Tyr Pro Lys Thr Gly Val Thr Gly Pro Tyr Val Leu Gly
65                  70                  75                  80  
Thr Gly Leu Ile Leu Tyr Ala Leu Ser Lys Gly Ile Tyr Val Ile Ser
                85                  90                  95      
Ala Glu Thr Phe Thr Ala Leu Ser Val Leu Gly Val Met Val Tyr Gly
            100                 105                 110         
Ile Lys Lys Tyr Gly Pro Phe Val Ala Asp Phe Ala Asp Lys Leu Asn
        115                 120                 125             
Glu Gln Lys Leu Ala Gln Leu Glu Glu Ala Lys Gln Ala Ser Ile Gln
    130                 135                 140                 
His Ile Gln Asn Ala Ile Asp Thr Glu Lys Ser Gln Gln Ala Leu Val
145                 150                 155                 160 
Gln Lys Arg His Tyr Leu Phe Asp Val Gln Arg Asn Asn Ile Ala Met
                165                 170                 175     
Ala Leu Glu Val Thr Tyr Arg Glu Arg Leu Tyr Arg Val Tyr Lys Glu
            180                 185                 190         
Val Arg Asn Arg Leu Asp Tyr His Ile Ser Val Gln Asn Met Met Arg
        195                 200                 205             
Arg Lys Glu Gln Glu His Met Ile Asn Trp Val Glu Lys His Val Val
    210                 215                 220                 
Gln Ser Ile Ser Thr Gln Gln Glu Lys Glu Thr Ile Ala Lys Cys Ile
225                 230                 235                 240 
Ala Asp Leu Lys Leu Leu Ala Lys Lys Ala Gln Ala Gln Pro Val Met
                245                 250                 255     


<210> 1584
<211> 89
<212> PRT
<213> Homo sapiens

<400> 1584
Val Gly Asn Leu Val Ser Glu Ser Ala Gly Arg Ser Ala Gly Gln Gly
 1               5                  10                  15      
Ser Pro Gly Pro Asp Ala Met Ser Arg Asn Leu Arg Thr Ala Leu Ile
            20                  25                  30          
Phe Gly Gly Phe Ile Ser Leu Ile Gly Ala Ala Phe Tyr Pro Ile Tyr
        35                  40                  45              
Phe Arg Pro Leu Met Arg Leu Glu Glu Tyr Lys Lys Glu Gln Ala Ile
    50                  55                  60                  
Asn Arg Ala Gly Ile Val Gln Glu Asp Val Gln Pro Pro Gly Leu Lys
65                  70                  75                  80  
Val Trp Ser Asp Pro Phe Gly Arg Lys
                85                  


<210> 1585
<211> 931
<212> PRT
<213> Homo sapiens

<400> 1585
Met Ala Ala Arg Asp Ser Asp Ser Glu Glu Asp Leu Val Ser Tyr Gly
 1               5                  10                  15      
Thr Gly Leu Glu Pro Leu Glu Glu Gly Glu Arg Pro Lys Lys Pro Ile
            20                  25                  30          
Pro Leu Gln Asp Gln Thr Val Arg Asp Glu Lys Gly Arg Tyr Lys Arg
        35                  40                  45              
Phe His Gly Ala Phe Ser Gly Gly Phe Ser Ala Gly Tyr Phe Asn Thr
    50                  55                  60                  
Val Gly Ser Lys Glu Gly Trp Thr Pro Ser Thr Phe Val Ser Ser Arg
65                  70                  75                  80  
Gln Asn Arg Ala Asp Lys Ser Val Leu Gly Pro Glu Asp Phe Met Asp
                85                  90                  95      
Glu Glu Asp Leu Ser Glu Phe Gly Ile Ala Pro Lys Ala Ile Val Thr
            100                 105                 110         
Thr Asp Asp Phe Ala Ser Lys Thr Lys Asp Arg Ile Arg Glu Lys Ala
        115                 120                 125             
Arg Gln Leu Ala Ala Ala Thr Ala Pro Ile Pro Gly Ala Thr Leu Leu
    130                 135                 140                 
Asp Asp Leu Ile Thr Pro Ala Lys Leu Ser Val Gly Phe Glu Leu Leu
145                 150                 155                 160 
Arg Lys Met Gly Trp Lys Glu Gly Gln Gly Val Gly Pro Arg Val Lys
                165                 170                 175     
Arg Arg Pro Arg Arg Gln Lys Pro Asp Pro Gly Val Lys Ile Tyr Gly
            180                 185                 190         
Cys Ala Leu Pro Pro Gly Ser Ser Glu Gly Ser Glu Gly Glu Asp Asp
        195                 200                 205             
Asp Tyr Leu Pro Asp Asn Val Thr Phe Ala Pro Lys Asp Val Thr Pro
    210                 215                 220                 
Val Asp Phe Thr Pro Lys Asp Asn Val His Gly Leu Ala Tyr Lys Gly
225                 230                 235                 240 
Leu Asp Pro His Gln Ala Leu Phe Gly Thr Ser Gly Glu His Phe Asn
                245                 250                 255     
Leu Phe Ser Gly Gly Ser Glu Arg Ala Gly Asp Leu Gly Glu Ile Gly
            260                 265                 270         
Leu Asn Lys Gly Arg Lys Leu Gly Ile Ser Gly Gln Ala Phe Gly Val
        275                 280                 285             
Gly Ala Leu Glu Glu Glu Asp Asp Asp Ile Tyr Ala Thr Glu Thr Leu
    290                 295                 300                 
Ser Lys Tyr Asp Thr Val Leu Lys Asp Glu Glu Pro Gly Asp Gly Leu
305                 310                 315                 320 
Tyr Gly Trp Thr Ala Pro Arg Gln Tyr Lys Asn Gln Lys Glu Ser Glu
                325                 330                 335     
Lys Asp Leu Arg Tyr Val Gly Lys Ile Leu Asp Gly Phe Ser Leu Ala
            340                 345                 350         
Ser Lys Pro Leu Ser Ser Lys Lys Ile Tyr Pro Pro Pro Glu Leu Pro
        355                 360                 365             
Arg Asp Tyr Arg Pro Val His Tyr Phe Arg Pro Met Val Ala Ala Thr
    370                 375                 380                 
Ser Glu Asn Ser His Leu Leu Gln Val Leu Ser Glu Ser Ala Gly Lys
385                 390                 395                 400 
Ala Thr Pro Asp Pro Gly Thr His Ser Lys His Gln Leu Asn Ala Ser
                405                 410                 415     
Lys Arg Ala Glu Leu Leu Gly Glu Thr Pro Ile Gln Gly Ser Ala Thr
            420                 425                 430         
Ser Val Leu Glu Phe Leu Ser Gln Lys Asp Lys Glu Arg Ile Lys Glu
        435                 440                 445             
Met Lys Gln Ala Thr Asp Leu Lys Ala Ala Gln Leu Lys Ala Arg Ser
    450                 455                 460                 
Leu Ala Gln Asn Ala Gln Ser Ser Arg Ala Gln Leu Ser Pro Ala Ala
465                 470                 475                 480 
Ala Ala Gly His Cys Ser Trp Asn Met Ala Leu Gly Gly Gly Thr Ala
                485                 490                 495     
Thr Leu Lys Ala Ser Asn Phe Lys Pro Phe Ala Lys Asp Pro Glu Lys
            500                 505                 510         
Gln Lys Arg Tyr Asp Glu Phe Leu Val His Met Lys Gln Gly Gln Lys
        515                 520                 525             
Asp Ala Leu Glu Arg Cys Leu Asp Pro Ser Met Thr Glu Trp Glu Arg
    530                 535                 540                 
Gly Arg Glu Arg Asp Glu Phe Ala Arg Ala Ala Leu Leu Tyr Ala Ser
545                 550                 555                 560 
Ser His Ser Thr Leu Ser Ser Arg Phe Thr His Ala Lys Glu Glu Asp
                565                 570                 575     
Asp Ser Asp Gln Val Glu Val Pro Arg Asp Gln Glu Asn Asp Val Gly
            580                 585                 590         
Asp Lys Gln Ser Ala Val Lys Met Lys Met Phe Gly Lys Leu Thr Arg
        595                 600                 605             
Asp Thr Phe Glu Trp His Pro Asp Lys Leu Leu Cys Lys Arg Phe Asn
    610                 615                 620                 
Val Pro Asp Pro Tyr Pro Asp Ser Thr Leu Val Gly Leu Pro Arg Val
625                 630                 635                 640 
Lys Arg Asp Lys Tyr Ser Val Phe Asn Phe Leu Thr Leu Pro Glu Thr
                645                 650                 655     
Ala Ser Leu Pro Thr Thr Gln Ala Ser Ser Glu Lys Val Ser Gln His
            660                 665                 670         
Arg Gly Pro Asp Lys Ser Arg Lys Pro Ser Arg Trp Asp Thr Ser Lys
        675                 680                 685             
His Glu Lys Lys Glu Asp Ser Ile Ser Glu Phe Leu Ser Leu Ala Arg
    690                 695                 700                 
Ser Lys Ala Glu Pro Pro Lys Gln Gln Ser Ser Pro Leu Val Asn Lys
705                 710                 715                 720 
Glu Glu Glu His Ala Pro Glu Leu Ser Ala Asn Gln Thr Val Asn Lys
                725                 730                 735     
Asp Val Asp Ala Gln Ala Glu Gly Glu Gly Ser Arg Pro Ser Met Asp
            740                 745                 750         
Leu Phe Arg Ala Ile Phe Ala Ser Ser Ser Asp Glu Lys Ser Ser Ser
        755                 760                 765             
Ser Glu Asp Glu Gln Gly Asp Ser Glu Asp Asp Gln Ala Gly Ser Gly
    770                 775                 780                 
Glu Ala Asn Phe Gln Ser Ser Gln Asp Thr Asp Leu Gly Glu Thr Ser
785                 790                 795                 800 
Ser Val Ala His Ala Leu Val Pro Ala Pro Gln Glu Pro Pro Pro Ser
                805                 810                 815     
Phe Pro Ile Gln Lys Met Gln Ile Asp Glu Arg Glu Glu Phe Gly Pro
            820                 825                 830         
Arg Leu Pro Pro Val Phe Cys Pro Asn Ala Arg Gln Thr Leu Glu Val
        835                 840                 845             
Pro Gln Lys Glu Lys His Lys Lys Asn Lys Asp Lys His Lys Ala Lys
    850                 855                 860                 
Lys Glu His Arg Arg Lys Lys Glu Lys Lys Lys Lys His Arg Lys His
865                 870                 875                 880 
Lys His Lys Gly Lys Gln Lys Asn Lys Lys Pro Glu Lys Ser Ser Ser
                885                 890                 895     
Ser Glu Ser Ser Asp Ser Ser Asp Ser Gln Ser Asp Glu Glu Thr Ala
            900                 905                 910         
Asp Val Ser Pro Gln Glu Leu Leu Arg Arg Leu Lys Ser Leu Pro Leu
        915                 920                 925             
Arg Arg Gln
    930     


<210> 1586
<211> 242
<212> PRT
<213> Homo sapiens

<400> 1586
Leu Lys Gln Leu Leu Ser Arg Leu Cys Gly Leu Leu Leu Glu Glu Gly
 1               5                  10                  15      
Ser His Pro Gly Ala Pro Ala Lys Pro Val Asp Leu Ala Pro Val Glu
            20                  25                  30          
Ala Pro Gly Pro Leu Ala Pro Val Pro Ser Thr Val Cys Pro Leu Arg
        35                  40                  45              
Arg Lys Leu Trp Gln Asn Tyr Arg Asn Leu Thr Phe Asp Pro Val Ser
    50                  55                  60                  
Ala Asn Arg His Phe Tyr Leu Ser Arg Gln Asp Gln Gln Val Lys His
65                  70                  75                  80  
Cys Arg Gln Ser Arg Gly Pro Gly Gly Pro Gly Ser Phe Glu Leu Trp
                85                  90                  95      
Gln Val Gln Cys Ala Gln Ser Phe Gln Ala Gly His His Tyr Trp Glu
            100                 105                 110         
Val Arg Ala Ser Asp His Ser Val Thr Leu Gly Val Ser Tyr Pro Gln
        115                 120                 125             
Leu Pro Arg Cys Arg Leu Gly Pro His Thr Asp Asn Ile Gly Arg Gly
    130                 135                 140                 
Pro Cys Ser Trp Gly Leu Cys Val Gln Glu Asp Ser Leu Gln Ala Trp
145                 150                 155                 160 
His Asn Gly Glu Ala Gln Arg Leu Pro Gly Val Ser Gly Arg Leu Leu
                165                 170                 175     
Gly Met Asp Leu Asp Leu Ala Ser Gly Cys Leu Thr Phe Tyr Ser Leu
            180                 185                 190         
Glu Pro Gln Thr Gln Pro Leu Tyr Thr Phe His Ala Leu Phe Asn Gln
        195                 200                 205             
Pro Leu Thr Pro Val Phe Trp Leu Leu Glu Gly Arg Thr Leu Thr Leu
    210                 215                 220                 
Cys His Gln Pro Gly Ala Val Phe Pro Leu Gly Pro Gln Glu Glu Val
225                 230                 235                 240 
Leu Ser
        


<210> 1587
<211> 259
<212> PRT
<213> Homo sapiens

<400> 1587
Phe Val Ile Pro His Gln Phe Ile His Arg Ile Cys Asp Glu Ile Thr
 1               5                  10                  15      
Gly Arg Val Pro Lys Lys Ala Leu Gly Ile Thr Leu Ile Lys Gly Ile
            20                  25                  30          
Asp Glu Gly Pro Glu Gly Leu Lys Leu Ile Ser Asp Ile Ile Arg Glu
        35                  40                  45              
Lys Met Gly Ile Asp Ile Ser Val Leu Met Gly Ala Asn Ile Ala Asn
    50                  55                  60                  
Glu Val Ala Ala Glu Lys Phe Cys Glu Thr Thr Ile Gly Ser Lys Val
65                  70                  75                  80  
Met Glu Asn Gly Leu Leu Phe Lys Glu Leu Leu Gln Thr Pro Asn Phe
                85                  90                  95      
Arg Ile Thr Val Val Asp Asp Ala Asp Thr Val Glu Leu Cys Gly Ala
            100                 105                 110         
Leu Lys Asn Ile Val Ala Val Gly Ala Gly Phe Cys Asp Gly Leu Arg
        115                 120                 125             
Cys Gly Asp Asn Thr Lys Ala Ala Val Ile Arg Leu Gly Leu Met Glu
    130                 135                 140                 
Met Ile Ala Phe Ala Arg Ile Phe Cys Lys Gly Gln Val Ser Thr Ala
145                 150                 155                 160 
Thr Phe Leu Glu Ser Cys Gly Val Ala Asp Leu Ile Thr Thr Cys Tyr
                165                 170                 175     
Gly Gly Arg Asn Arg Arg Val Ala Glu Ala Phe Ala Arg Thr Gly Lys
            180                 185                 190         
Thr Ile Glu Glu Leu Glu Lys Glu Met Leu Asn Gly Gln Lys Leu Gln
        195                 200                 205             
Gly Pro Gln Thr Ser Ala Glu Val Tyr Arg Ile Leu Lys Gln Lys Gly
    210                 215                 220                 
Leu Leu Asp Lys Phe Pro Leu Phe Thr Ala Val Tyr Gln Ile Cys Tyr
225                 230                 235                 240 
Glu Ser Arg Pro Val Gln Glu Met Leu Ser Cys Leu Gln Ser His Pro
                245                 250                 255     
Glu His Thr
            


<210> 1588
<211> 505
<212> PRT
<213> Homo sapiens

<400> 1588
Ala Leu Gly Phe Leu Ser Ser Tyr Gly Ile Gly Met Glu Tyr Asp Gln
 1               5                  10                  15      
Ala Lys Ala Leu Ile Tyr Tyr Thr Phe Gly Ser Ala Gly Gly Asn Met
            20                  25                  30          
Met Ser Gln Met Ile Leu Gly Tyr Arg Tyr Leu Ser Gly Ile Asn Val
        35                  40                  45              
Leu Gln Asn Cys Glu Val Ala Leu Ser Tyr Tyr Lys Lys Val Ala Asp
    50                  55                  60                  
Tyr Ile Ala Asp Thr Phe Glu Lys Ser Glu Gly Val Pro Val Glu Lys
65                  70                  75                  80  
Val Arg Leu Thr Glu Arg Pro Glu Asn Leu Ser Ser Asn Ser Glu Ile
                85                  90                  95      
Leu Asp Trp Asp Ile Tyr Gln Tyr Tyr Lys Phe Leu Ala Glu Arg Gly
            100                 105                 110         
Asp Val Gln Ile Gln Val Ser Leu Gly Gln Leu His Leu Ile Gly Arg
        115                 120                 125             
Lys Gly Leu Asp Gln Asp Tyr Tyr Lys Ala Leu His Tyr Phe Leu Lys
    130                 135                 140                 
Ala Ala Lys Ala Gly Ser Ala Asn Ala Met Ala Phe Ile Gly Lys Met
145                 150                 155                 160 
Tyr Leu Glu Gly Asn Ala Ala Val Pro Gln Asn Asn Ala Thr Ala Phe
                165                 170                 175     
Lys Tyr Phe Ser Met Ala Ala Ser Lys Gly Asn Ala Ile Gly Leu His
            180                 185                 190         
Gly Leu Gly Leu Leu Tyr Phe His Gly Lys Gly Val Pro Leu Asn Tyr
        195                 200                 205             
Ala Glu Ala Leu Lys Tyr Phe Gln Lys Ala Ala Glu Lys Gly Trp Pro
    210                 215                 220                 
Asp Ala Gln Phe Gln Leu Gly Phe Met Tyr Tyr Ser Gly Ser Gly Ile
225                 230                 235                 240 
Trp Lys Asp Tyr Lys Leu Ala Phe Lys Tyr Phe Tyr Leu Ala Ser Gln
                245                 250                 255     
Ser Gly Gln Pro Leu Ala Ile Tyr Tyr Leu Ala Lys Met Tyr Ala Thr
            260                 265                 270         
Gly Thr Gly Val Val Arg Ser Cys Arg Thr Ala Val Glu Leu Tyr Lys
        275                 280                 285             
Gly Val Cys Glu Leu Gly His Trp Ala Glu Lys Phe Leu Thr Ala Tyr
    290                 295                 300                 
Phe Ala Tyr Lys Asp Gly Asp Ile Asp Ser Ser Leu Val Gln Tyr Ala
305                 310                 315                 320 
Leu Leu Ala Glu Met Gly Tyr Glu Val Ala Gln Ser Asn Ser Ala Phe
                325                 330                 335     
Ile Leu Glu Ser Lys Lys Ala Asn Ile Leu Glu Lys Glu Lys Met Tyr
            340                 345                 350         
Pro Met Ala Leu Leu Leu Trp Asn Arg Ala Ala Ile Gln Gly Asn Ala
        355                 360                 365             
Phe Ala Arg Val Lys Ile Gly Asp Tyr His Tyr Tyr Gly Tyr Gly Thr
    370                 375                 380                 
Lys Lys Asp Tyr Gln Thr Ala Ala Thr His Tyr Ser Ile Ala Ala Asn
385                 390                 395                 400 
Lys Tyr His Asn Ala Gln Ala Met Phe Asn Leu Ala Tyr Met Tyr Glu
                405                 410                 415     
His Gly Leu Gly Ile Thr Lys Asp Ile His Leu Ala Arg Arg Leu Tyr
            420                 425                 430         
Asp Met Ala Ala Gln Thr Ser Pro Asp Ala His Ile Pro Val Leu Phe
        435                 440                 445             
Ala Val Met Lys Leu Glu Thr Thr His Leu Leu Arg Asp Ile Leu Phe
    450                 455                 460                 
Phe Asn Phe Thr Thr Arg Trp Asn Trp Leu Lys Leu Asp Asn Thr Ile
465                 470                 475                 480 
Gly Pro His Trp Asp Leu Phe Val Ile Gly Leu Ile Val Pro Gly Leu
                485                 490                 495     
Ile Leu Leu Leu Arg Asn His His Gly
            500                 505 


<210> 1589
<211> 267
<212> PRT
<213> Homo sapiens

<400> 1589
Met Ala Ala Pro Val Val Thr Ala Pro Gly Arg Ala Leu Leu Arg Ala
 1               5                  10                  15      
Gly Ala Gly Arg Leu Leu Arg Gly Gly Val Gln Glu Leu Leu Arg Pro
            20                  25                  30          
Arg His Glu Gly Asn Ala Pro Asp Leu Ala Cys Asn Phe Ser Leu Ser
        35                  40                  45              
Gln Asn Arg Gly Thr Val Ile Val Glu Arg Trp Trp Lys Val Pro Leu
    50                  55                  60                  
Ala Gly Glu Gly Arg Lys Pro Arg Leu His Arg Arg His Arg Val Tyr
65                  70                  75                  80  
Lys Leu Val Glu Asp Thr Lys His Arg Pro Lys Glu Asn Leu Glu Leu
                85                  90                  95      
Ile Leu Thr Gln Ser Val Glu Asn Val Gly Val Arg Gly Asp Leu Val
            100                 105                 110         
Ser Val Lys Lys Ser Leu Gly Arg Asn Arg Leu Leu Pro Gln Gly Leu
        115                 120                 125             
Ala Val Tyr Ala Ser Pro Glu Asn Lys Lys Leu Phe Glu Glu Glu Lys
    130                 135                 140                 
Leu Leu Arg Gln Glu Gly Lys Leu Glu Lys Ile Gln Thr Lys Ala Gly
145                 150                 155                 160 
Glu Ala Thr Val Lys Phe Leu Lys Ser Cys Arg Leu Glu Val Gly Met
                165                 170                 175     
Lys Asn Asn Val Lys Trp Glu Leu Asn Pro Glu Ile Val Ala Arg His
            180                 185                 190         
Phe Phe Lys Asn Leu Gly Val Val Val Ala Pro His Thr Leu Lys Leu
        195                 200                 205             
Pro Ala Glu Pro Ile Thr Arg Trp Gly Glu Tyr Trp Cys Glu Val Thr
    210                 215                 220                 
Val Asn Gly Leu Asp Thr Val Arg Val Pro Met Ser Val Val Asn Phe
225                 230                 235                 240 
Glu Lys Pro Lys Thr Lys Arg Tyr Lys Tyr Trp Leu Ala Gln Gln Ala
                245                 250                 255     
Ala Lys Ala Met Ala Pro Thr Ser Pro Gln Ile
            260                 265         


<210> 1590
<211> 197
<212> PRT
<213> Homo sapiens

<400> 1590
Met Thr Ala Arg Gly Thr Pro Ser Arg Phe Leu Ala Ser Val Leu His
 1               5                  10                  15      
Asn Gly Leu Gly Arg Tyr Val Gln Gln Leu Gln Arg Leu Ser Phe Ser
            20                  25                  30          
Val Ser Arg Asp Gly Ala Ser Ser Arg Gly Ala Arg Glu Phe Val Glu
        35                  40                  45              
Arg Glu Val Ile Asp Phe Ala Arg Arg Asn Pro Gly Val Val Ile Tyr
    50                  55                  60                  
Val Asn Ser Arg Pro Cys Cys Val Pro Arg Val Val Ala Glu Tyr Leu
65                  70                  75                  80  
Asn Gly Ala Val Arg Glu Glu Ser Ile His Cys Lys Ser Val Glu Glu
                85                  90                  95      
Ile Ser Thr Leu Val Gln Lys Leu Ala Asp Gln Ser Gly Leu Asp Val
            100                 105                 110         
Ile Arg Ile Arg Lys Pro Phe His Thr Asp Asn Pro Ser Ile Gln Gly
        115                 120                 125             
Gln Trp Thr Pro Ser Pro Thr Ser Arg Pro Arg Ser Ala Gly Tyr Ala
    130                 135                 140                 
Pro Glu Arg Phe Arg Ile Leu Pro Gln Pro Arg Cys Lys His Ser Glu
145                 150                 155                 160 
Glu Leu Pro His Gln Leu Gln Pro Gln Ala Leu Asp Cys Tyr Ser Gly
                165                 170                 175     
Lys Gly Gly Ser Ser Pro Leu Gly Phe Gln Ala Gln Ala Asn Gly Thr
            180                 185                 190         
His Gln Trp Ala Ser
        195         


<210> 1591
<211> 1207
<212> PRT
<213> Homo sapiens

<400> 1591
Met Ser Ser Gly Asp Pro Ala His Leu Gly Leu Cys Leu Trp Leu Trp
 1               5                  10                  15      
Leu Gly Ala Thr Leu Gly Arg Glu Gln Val Gln Ala Ser Gly Leu Leu
            20                  25                  30          
Arg Leu Ala Val Leu Pro Glu Asp Arg Leu Gln Met Lys Trp Arg Glu
        35                  40                  45              
Ser Glu Gly Ser Gly Leu Gly Tyr Leu Val Gln Val Lys Pro Met Ala
    50                  55                  60                  
Gly Asp Ser Glu Gln Glu Val Ile Leu Thr Thr Lys Thr Pro Lys Ala
65                  70                  75                  80  
Thr Val Gly Gly Leu Ser Pro Ser Lys Gly Tyr Thr Leu Gln Ile Phe
                85                  90                  95      
Glu Leu Thr Gly Ser Gly Arg Phe Leu Leu Ala Arg Arg Glu Phe Val
            100                 105                 110         
Ile Glu Asp Leu Lys Ser Ser Ser Leu Asp Arg Ser Ser Gln Arg Pro
        115                 120                 125             
Leu Gly Ser Gly Ala Pro Glu Pro Thr Pro Ser His Thr Gly Ser Pro
    130                 135                 140                 
Asp Pro Glu Gln Ala Ser Glu Pro Gln Val Ala Phe Thr Pro Ser Gln
145                 150                 155                 160 
Asp Pro Arg Thr Pro Gly Gly Ser Glu Trp Arg Glu Thr Gly Pro Gln
                165                 170                 175     
Phe Arg Cys Leu Pro Pro Val Pro Ala Asp Met Val Phe Leu Val Asp
            180                 185                 190         
Gly Ser Trp Ser Ile Gly His Ser His Phe Gln Gln Val Lys Asp Phe
        195                 200                 205             
Leu Ala Ser Val Ile Ala Pro Phe Glu Ile Gly Pro Asp Lys Val Gln
    210                 215                 220                 
Val Gly Leu Thr Gln Tyr Ser Gly Asp Ala Gln Thr Glu Trp Asp Leu
225                 230                 235                 240 
Asn Ser Leu Ser Thr Lys Glu Gln Val Leu Ala Ala Val Arg Arg Leu
                245                 250                 255     
Arg Tyr Lys Gly Gly Asn Thr Phe Thr Gly Leu Ala Leu Thr His Val
            260                 265                 270         
Leu Gly Gln Asn Leu Gln Pro Ala Ala Gly Leu Arg Pro Glu Ala Ala
        275                 280                 285             
Lys Val Val Ile Leu Val Thr Asp Gly Lys Ser Gln Asp Asp Val His
    290                 295                 300                 
Thr Ala Ala Arg Val Leu Lys Asp Leu Gly Val Asn Val Phe Ala Val
305                 310                 315                 320 
Gly Val Lys Asn Ala Asp Glu Ala Glu Leu Arg Leu Leu Ala Ser Pro
                325                 330                 335     
Pro Arg Asp Ile Thr Val His Ser Val Leu Asp Phe Leu Gln Leu Gly
            340                 345                 350         
Ala Leu Ala Gly Leu Leu Ser Arg Leu Ile Cys Gln Arg Leu Gln Gly
        355                 360                 365             
Gly Ser Pro Arg Gln Gly Pro Ala Ala Ala Pro Ala Leu Asp Thr Leu
    370                 375                 380                 
Pro Ala Pro Thr Ser Leu Val Leu Ser Gln Val Thr Ser Ser Ser Ile
385                 390                 395                 400 
Arg Leu Ser Trp Thr Pro Ala Pro Arg His Pro Leu Lys Tyr Leu Ile
                405                 410                 415     
Val Trp Arg Ala Ser Arg Gly Gly Thr Pro Arg Glu Val Val Val Glu
            420                 425                 430         
Gly Pro Ala Ala Ser Thr Glu Leu His Asn Leu Ala Ser Arg Thr Glu
        435                 440                 445             
Tyr Leu Val Ser Val Phe Pro Ile Tyr Glu Gly Gly Val Gly Glu Gly
    450                 455                 460                 
Leu Arg Gly Leu Val Thr Thr Ala Pro Leu Pro Pro Pro Arg Ala Leu
465                 470                 475                 480 
Thr Leu Ala Ala Val Thr Pro Arg Thr Val His Leu Thr Trp Gln Pro
                485                 490                 495     
Ser Ala Gly Ala Thr His Tyr Leu Val Arg Cys Ser Pro Ala Ser Pro
            500                 505                 510         
Lys Gly Glu Glu Glu Glu Arg Glu Val Gln Val Gly Arg Pro Glu Val
        515                 520                 525             
Leu Leu Asp Gly Leu Glu Pro Gly Arg Asp Tyr Glu Val Ser Val Gln
    530                 535                 540                 
Ser Leu Arg Gly Pro Glu Gly Ser Glu Ala Arg Gly Ile Arg Ala Arg
545                 550                 555                 560 
Thr Pro Thr Leu Ala Pro Pro Arg His Leu Gly Phe Ser Asp Val Ser
                565                 570                 575     
His Asp Ala Ala Arg Val Phe Trp Glu Gly Ala Pro Arg Pro Val Arg
            580                 585                 590         
Leu Val Arg Val Thr Tyr Val Ser Ser Glu Gly Gly His Ser Gly Gln
        595                 600                 605             
Thr Glu Ala Pro Gly Asn Ala Thr Ser Ala Thr Leu Gly Pro Leu Ser
    610                 615                 620                 
Ser Ser Thr Thr Tyr Thr Val Arg Val Thr Cys Leu Tyr Pro Gly Gly
625                 630                 635                 640 
Gly Ser Ser Thr Leu Thr Gly Arg Val Thr Thr Lys Lys Ala Pro Ser
                645                 650                 655     
Pro Ser Gln Leu Ser Met Thr Glu Leu Pro Gly Asp Ala Val Gln Leu
            660                 665                 670         
Ala Trp Val Ala Ala Ala Pro Ser Gly Val Leu Val Tyr Gln Ile Thr
        675                 680                 685             
Trp Thr Pro Leu Gly Glu Gly Lys Ala His Glu Ile Ser Val Pro Gly
    690                 695                 700                 
Asn Leu Gly Thr Ala Val Leu Pro Gly Leu Gly Arg His Thr Glu Tyr
705                 710                 715                 720 
Asp Val Thr Ile Leu Ala Tyr Tyr Arg Asp Gly Ala Arg Ser Asp Pro
                725                 730                 735     
Val Ser Leu Arg Tyr Thr Pro Ser Thr Val Ser Arg Ser Pro Pro Ser
            740                 745                 750         
Asn Leu Ala Leu Ala Ser Glu Thr Pro Asp Ser Leu Gln Val Ser Trp
        755                 760                 765             
Thr Pro Pro Leu Gly Arg Val Leu His Tyr Trp Leu Thr Tyr Ala Pro
    770                 775                 780                 
Ala Ser Gly Leu Gly Pro Glu Lys Ser Val Ser Val Pro Gly Ala Arg
785                 790                 795                 800 
Ser His Val Thr Leu Pro Asp Leu Gln Ala Ala Thr Lys Tyr Arg Val
                805                 810                 815     
Leu Val Ser Ala Ile Tyr Ala Ala Gly Arg Ser Glu Ala Val Ser Ala
            820                 825                 830         
Thr Gly Gln Thr Ala Cys Pro Ala Leu Arg Pro Asp Gly Ser Leu Pro
        835                 840                 845             
Gly Phe Asp Leu Met Val Ala Phe Ser Leu Val Glu Lys Ala Tyr Ala
    850                 855                 860                 
Ser Ile Arg Gly Val Ala Met Glu Pro Ser Ala Phe Gly Gly Thr Pro
865                 870                 875                 880 
Thr Phe Thr Leu Phe Lys Asp Ala Gln Leu Thr Arg Arg Val Ser Asp
                885                 890                 895     
Val Tyr Pro Ala Pro Leu Pro Pro Glu His Thr Ile Val Phe Leu Val
            900                 905                 910         
Arg Leu Leu Pro Glu Thr Pro Arg Glu Ala Phe Ala Leu Trp Gln Met
        915                 920                 925             
Thr Ala Glu Asp Phe Gln Pro Leu Leu Gly Val Leu Leu Asp Ala Gly
    930                 935                 940                 
Lys Lys Ser Leu Thr Tyr Phe His Arg Asp Pro Arg Ala Ala Leu Gln
945                 950                 955                 960 
Glu Ala Thr Phe Asp Pro Gln Glu Val Arg Lys Ile Phe Phe Gly Ser
                965                 970                 975     
Phe His Lys Val His Val Ala Val Gly Arg Ser Lys Val Arg Leu Tyr
            980                 985                 990         
Val Asp Cys Arg Lys Val Ala Glu Arg Pro Leu Gly Glu Met Gly Ser
        995                 1000                1005            
Pro Pro Ala Ala Gly Phe Val Thr Leu Gly Arg Leu Ala Lys Ala Arg
    1010                1015                1020                
Gly Pro Arg Ser Ser Ser Ala Ala Phe Gln Leu Gln Met Leu Gln Ile
1025                1030                1035                1040
Val Cys Ser Asp Thr Trp Ala Asp Glu Asp Arg Cys Cys Glu Leu Pro
                1045                1050                1055    
Ala Ser Arg Asp Gly Glu Thr Cys Pro Ala Phe Val Ser Ala Cys Ser
            1060                1065                1070        
Cys Ser Ser Glu Thr Pro Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly
        1075                1080                1085            
Leu Pro Gly Arg Asn Gly Thr Pro Gly Glu Gln Gly Phe Pro Gly Pro
    1090                1095                1100                
Arg Gly Pro Pro Gly Val Lys Gly Glu Lys Gly Asp His Gly Leu Pro
1105                1110                1115                1120
Gly Leu Gln Gly His Pro Gly His Gln Gly Ile Pro Gly Arg Val Gly
                1125                1130                1135    
Leu Gln Gly Pro Lys Gly Met Arg Gly Leu Glu Gly Thr Ala Gly Leu
            1140                1145                1150        
Pro Gly Pro Leu Ala Pro Gly Gly Ser Arg Ala Trp Gln Gly Pro Gly
        1155                1160                1165            
Ala Leu Val Glu Ser Glu Asp Leu Gln Gly Pro Trp Gly Pro Gln Asp
    1170                1175                1180                
Cys Gln Gly Pro Lys Gly Asn Glu Glu Arg Arg Ala Ser Arg Ser Pro
1185                1190                1195                1200
Leu Pro Pro Ser Thr Ser Leu
                1205        


<210> 1592
<211> 521
<212> PRT
<213> Homo sapiens

<400> 1592
Met Ala Ala His Leu Val Lys Arg Cys Thr Cys Leu Leu Arg Glu Ala
 1               5                  10                  15      
Ala Arg Gln Ala Pro Ala Met Ala Pro Val Gly Arg Leu Arg Leu Ala
            20                  25                  30          
Trp Val Ala His Lys Thr Leu Thr Ser Ser Ala Thr Ser Pro Ile Ser
        35                  40                  45              
His Leu Pro Gly Ser Leu Met Glu Pro Val Glu Lys Glu Arg Ala Ser
    50                  55                  60                  
Thr Pro Tyr Ile Glu Lys Gln Val Asp His Leu Ile Lys Lys Ala Thr
65                  70                  75                  80  
Arg Pro Glu Glu Leu Leu Glu Leu Leu Gly Gly Ser His Asp Leu Asp
                85                  90                  95      
Ser Asn Gln Ala Ala Met Val Leu Ile Arg Leu Ser His Leu Leu Ser
            100                 105                 110         
Glu Lys Pro Glu Asp Lys Gly Leu Leu Ile Gln Asp Ala His Phe His
        115                 120                 125             
Gln Leu Leu Cys Leu Leu Asn Ser Gln Ile Ala Ser Val Trp His Gly
    130                 135                 140                 
Thr Leu Ser Lys Leu Leu Gly Ser Leu Tyr Ala Leu Gly Ile Pro Lys
145                 150                 155                 160 
Ala Ser Lys Glu Leu Gln Ser Val Glu Gln Glu Val Arg Trp Arg Met
                165                 170                 175     
Arg Lys Leu Lys Tyr Lys His Leu Ala Phe Leu Ala Glu Ser Cys Ala
            180                 185                 190         
Thr Leu Ser Gln Glu Gln His Ser Gln Glu Leu Leu Ala Glu Leu Leu
        195                 200                 205             
Thr His Leu Glu Arg Arg Trp Thr Glu Ile Glu Asp Ser His Thr Leu
    210                 215                 220                 
Val Thr Val Met Met Lys Val Gly His Leu Ser Glu Pro Leu Met Asn
225                 230                 235                 240 
Arg Leu Glu Asp Lys His Val Leu Asn Arg Ala Gln Asp Ile Thr Leu
                245                 250                 255     
Pro His Leu Cys Ser Val Leu Leu Ala Phe Ala Arg Leu Asn Phe His
            260                 265                 270         
Pro Asp Gln Glu Asp Gln Phe Phe Ser Leu Val His Glu Lys Leu Gly
        275                 280                 285             
Ser Glu Leu Pro Gly Leu Glu Pro Ala Leu Gln Val Asp Leu Val Trp
    290                 295                 300                 
Ala Leu Cys Val Leu Gln Gln Ala Arg Glu Ala Glu Leu Gln Ala Val
305                 310                 315                 320 
Leu His Pro Glu Phe His Ile Gln Phe Leu Gly Gly Lys Ser Gln Lys
                325                 330                 335     
Asp Gln Asn Thr Phe Gln Lys Leu Leu His Ile Asn Ala Thr Ala Leu
            340                 345                 350         
Leu Glu Tyr Pro Glu Tyr Ser Gly Pro Leu Leu Pro Ala Ser Ala Val
        355                 360                 365             
Ala Pro Gly Pro Ser Ala Leu Asp Arg Lys Val Thr Pro Leu Gln Lys
    370                 375                 380                 
Glu Leu Gln Glu Thr Leu Lys Gly Leu Leu Gly Ser Ala Asp Lys Gly
385                 390                 395                 400 
Ser Leu Glu Val Ala Thr Gln Tyr Gly Trp Val Leu Asp Ala Glu Val
                405                 410                 415     
Leu Leu Asp Ser Asp Gly Glu Phe Leu Pro Val Arg Asp Phe Val Ala
            420                 425                 430         
Pro His Leu Ala Gln Pro Thr Gly Ser Gln Ser Pro Pro Pro Gly Ser
        435                 440                 445             
Lys Arg Leu Ala Phe Leu Arg Trp Glu Phe Pro Asn Phe Asn Ser Arg
    450                 455                 460                 
Ser Lys Asp Leu Leu Gly Arg Phe Val Leu Ala Arg Arg His Ile Val
465                 470                 475                 480 
Ala Ala Gly Phe Leu Ile Val Asp Val Pro Phe Tyr Glu Trp Leu Glu
                485                 490                 495     
Leu Lys Ser Glu Trp Gln Lys Gly Ala Tyr Leu Lys Asp Lys Met Arg
            500                 505                 510         
Lys Ala Val Ala Glu Glu Leu Ala Lys
        515                 520     


<210> 1593
<211> 774
<212> PRT
<213> Homo sapiens

<400> 1593
Met Glu Pro Glu Arg Glu Gly Thr Glu Arg His Pro Arg Lys Val Arg
 1               5                  10                  15      
Glu Gly Arg Gln Ala Pro Asn Lys Leu Val Gly Ala Ala Glu Ala Met
            20                  25                  30          
Lys Ala Gly Trp Asp Leu Glu Glu Ser Gln Pro Glu Ala Lys Lys Ala
        35                  40                  45              
Arg Leu Ser Thr Ile Leu Phe Thr Asp Asn Cys Glu Val Thr His Asp
    50                  55                  60                  
Gln Leu Cys Glu Leu Leu Lys Tyr Ala Val Leu Gly Lys Ser Asn Val
65                  70                  75                  80  
Pro Lys Pro Ser Trp Cys Gln Leu Phe His Gln Asn His Leu Asn Asn
                85                  90                  95      
Val Val Val Phe Val Leu Gln Gly Met Ser Gln Leu His Phe Tyr Arg
            100                 105                 110         
Phe Tyr Leu Glu Phe Gly Cys Leu Arg Lys Ala Phe Arg His Lys Phe
        115                 120                 125             
Arg Leu Pro Pro Pro Ser Ser Asp Phe Leu Ala Asp Val Val Gly Leu
    130                 135                 140                 
Gln Thr Glu Gln Arg Ala Gly Asp Leu Pro Lys Thr Met Glu Gly Pro
145                 150                 155                 160 
Leu Pro Ser Asn Ala Lys Ala Ala Ile Asn Leu Gln Asp Asp Pro Ile
                165                 170                 175     
Ile Gln Lys Tyr Gly Ser Lys Lys Val Gly Leu Thr Arg Cys Leu Leu
            180                 185                 190         
Thr Lys Glu Glu Met Arg Thr Phe His Phe Pro Leu Gln Gly Phe Pro
        195                 200                 205             
Asp Cys Glu Asn Phe Leu Leu Thr Lys Cys Asn Gly Ser Ile Ala Asp
    210                 215                 220                 
Asn Ser Pro Leu Phe Gly Leu Asp Cys Glu Met Cys Leu Thr Ser Lys
225                 230                 235                 240 
Gly Arg Glu Leu Thr Arg Ile Ser Leu Val Ala Glu Gly Gly Cys Cys
                245                 250                 255     
Val Met Asp Glu Leu Val Lys Pro Glu Asn Lys Ile Leu Asp Tyr Leu
            260                 265                 270         
Thr Ser Phe Ser Gly Ile Thr Lys Lys Ile Leu Asn Pro Val Thr Thr
        275                 280                 285             
Lys Leu Lys Asp Val Gln Arg Gln Leu Lys Ala Leu Leu Pro Pro Asp
    290                 295                 300                 
Ala Val Leu Val Gly His Ser Leu Asp Leu Asp Leu Arg Ala Leu Lys
305                 310                 315                 320 
Met Ile His Pro Tyr Val Ile Asp Thr Ser Leu Leu Tyr Val Arg Glu
                325                 330                 335     
Gln Gly Arg Arg Phe Lys Leu Lys Phe Leu Ala Lys Val Ile Leu Gly
            340                 345                 350         
Lys Asp Ile Gln Cys Pro Asp Arg Leu Gly His Asp Ala Thr Glu Asp
        355                 360                 365             
Ala Arg Thr Ile Leu Glu Leu Ala Arg Tyr Phe Leu Lys His Gly Pro
    370                 375                 380                 
Lys Lys Ile Ala Glu Leu Asn Leu Glu Ala Leu Ala Asn His Gln Glu
385                 390                 395                 400 
Ile Gln Ala Ala Gly Gln Glu Pro Lys Asn Thr Ala Glu Val Leu Gln
                405                 410                 415     
His Pro Asn Thr Ser Val Leu Glu Cys Leu Asp Ser Val Gly Gln Lys
            420                 425                 430         
Leu Leu Phe Leu Thr Arg Glu Thr Asp Ala Gly Glu Leu Pro Ser Ser
        435                 440                 445             
Arg Asn Cys Gln Thr Ile Lys Cys Leu Ser Asn Lys Glu Val Leu Glu
    450                 455                 460                 
Gln Ala Arg Val Glu Ile Pro Leu Phe Pro Phe Ser Ile Val Gln Phe
465                 470                 475                 480 
Ser Phe Lys Ala Phe Ser Pro Val Leu Thr Glu Glu Met Asn Lys Arg
                485                 490                 495     
Met Arg Ile Lys Trp Thr Glu Ile Ser Thr Val Tyr Ala Gly Pro Phe
            500                 505                 510         
Ser Lys Asn Cys Asn Leu Arg Ala Leu Lys Arg Leu Phe Lys Ser Phe
        515                 520                 525             
Gly Pro Val Gln Ser Met Thr Phe Val Leu Glu Thr Arg Gln Pro His
    530                 535                 540                 
Leu Cys Ile Gln Tyr Glu Val Leu Glu Ala Ala Gln Leu Ala Ile Glu
545                 550                 555                 560 
Ser Leu Asp Gly Ile Leu Val Asp Gly Ile Cys Ile Lys Val Gln Arg
                565                 570                 575     
Pro Val Thr Glu Leu Thr Leu Asp Cys Asp Thr Leu Val Asn Glu Leu
            580                 585                 590         
Glu Gly Asp Ser Glu Asn Gln Gly Ser Ile Tyr Leu Ser Gly Val Ser
        595                 600                 605             
Glu Thr Phe Lys Glu Gln Leu Leu Gln Glu Pro Arg Leu Phe Leu Gly
    610                 615                 620                 
Leu Glu Ala Val Ile Leu Pro Lys Asp Leu Lys Ser Gly Lys Gln Lys
625                 630                 635                 640 
Lys Tyr Cys Phe Leu Lys Phe Lys Ser Phe Gly Ser Ala Gln Gln Ala
                645                 650                 655     
Leu Asn Ile Leu Thr Gly Lys Asp Trp Lys Leu Lys Gly Arg His Ala
            660                 665                 670         
Leu Thr Pro Arg His Leu His Ala Trp Leu Arg Gly Leu Pro Pro Glu
        675                 680                 685             
Ser Thr Arg Leu Pro Gly Leu Arg Val Val Pro Pro Pro Phe Glu Gln
    690                 695                 700                 
Glu Ala Leu Gln Thr Leu Lys Leu Asp His Pro Lys Ile Ala Ala Trp
705                 710                 715                 720 
Arg Trp Ser Arg Lys Ile Gly Lys Leu Tyr Asn Ser Leu Cys Pro Gly
                725                 730                 735     
Thr Leu Cys Leu Ile Leu Leu Pro Gly Thr Lys Ser Thr His Gly Ser
            740                 745                 750         
Leu Ser Gly Leu Gly Leu Met Gly Ile Lys Glu Glu Glu Glu Ser Ala
        755                 760                 765             
Gly Pro Gly Leu Cys Ser
    770                 


<210> 1594
<211> 811
<212> PRT
<213> Homo sapiens

<400> 1594
Met Arg Leu Ile Arg Asn Ile Tyr Ile Phe Cys Ser Ile Val Met Thr
 1               5                  10                  15      
Ala Glu Gly Asp Ala Pro Glu Leu Pro Glu Glu Arg Glu Leu Met Thr
            20                  25                  30          
Asn Cys Ser Asn Met Ser Leu Arg Lys Val Pro Ala Asp Leu Thr Pro
        35                  40                  45              
Ala Thr Thr Thr Leu Asp Leu Ser Tyr Asn Leu Leu Phe Gln Leu Gln
    50                  55                  60                  
Ser Ser Asp Phe His Ser Val Ser Lys Leu Arg Val Leu Ile Leu Cys
65                  70                  75                  80  
His Asn Arg Ile Gln Gln Leu Asp Leu Lys Thr Phe Glu Phe Asn Lys
                85                  90                  95      
Glu Leu Arg Tyr Leu Asp Leu Ser Asn Asn Arg Leu Lys Ser Val Thr
            100                 105                 110         
Trp Tyr Leu Leu Ala Gly Leu Arg Tyr Leu Asp Leu Ser Phe Asn Asp
        115                 120                 125             
Phe Asp Thr Met Pro Ile Cys Glu Glu Ala Gly Asn Met Ser His Leu
    130                 135                 140                 
Glu Ile Leu Gly Leu Ser Gly Ala Lys Ile Gln Lys Ser Asp Phe Gln
145                 150                 155                 160 
Lys Ile Ala His Leu His Leu Asn Thr Val Phe Leu Gly Phe Arg Thr
                165                 170                 175     
Leu Pro His Tyr Glu Glu Gly Ser Leu Pro Ile Leu Asn Thr Thr Lys
            180                 185                 190         
Leu His Ile Val Leu Pro Met Asp Thr Asn Phe Trp Val Leu Leu Arg
        195                 200                 205             
Asp Gly Ile Lys Thr Ser Lys Ile Leu Glu Met Thr Asn Ile Asp Gly
    210                 215                 220                 
Lys Ser Gln Phe Val Ser Tyr Glu Met Gln Arg Asn Leu Ser Leu Glu
225                 230                 235                 240 
Asn Ala Lys Thr Ser Val Leu Leu Leu Asn Lys Val Asp Leu Leu Trp
                245                 250                 255     
Asp Asp Leu Phe Leu Ile Leu Gln Phe Val Trp His Thr Ser Val Glu
            260                 265                 270         
His Phe Gln Ile Arg Asn Val Thr Phe Gly Gly Lys Ala Tyr Leu Asp
        275                 280                 285             
His Asn Ser Phe Asp Tyr Ser Asn Thr Val Met Arg Thr Ile Lys Leu
    290                 295                 300                 
Glu His Val His Phe Arg Val Phe Tyr Ile Gln Gln Asp Lys Ile Tyr
305                 310                 315                 320 
Leu Leu Leu Thr Lys Met Asp Ile Glu Asn Leu Thr Ile Ser Asn Ala
                325                 330                 335     
Gln Met Pro His Met Leu Phe Pro Asn Tyr Pro Thr Lys Phe Gln Tyr
            340                 345                 350         
Leu Asn Phe Ala Asn Asn Ile Leu Thr Asp Glu Leu Phe Lys Arg Thr
        355                 360                 365             
Ile Gln Leu Pro His Leu Lys Thr Leu Ile Leu Asn Gly Asn Lys Leu
    370                 375                 380                 
Glu Thr Leu Ser Leu Val Ser Cys Phe Ala Asn Asn Thr Pro Leu Glu
385                 390                 395                 400 
His Leu Asp Leu Ser Gln Asn Leu Leu Gln His Lys Asn Asp Glu Asn
                405                 410                 415     
Cys Ser Trp Pro Glu Thr Val Val Asn Met Asn Leu Ser Tyr Asn Lys
            420                 425                 430         
Leu Ser Asp Ser Val Phe Arg Cys Leu Pro Lys Ser Ile Gln Ile Leu
        435                 440                 445             
Asp Leu Asn Asn Asn Gln Ile Gln Thr Val Pro Lys Glu Thr Ile His
    450                 455                 460                 
Leu Met Ala Leu Arg Glu Leu Asn Ile Ala Phe Asn Phe Leu Thr Asp
465                 470                 475                 480 
Leu Pro Gly Cys Ser His Phe Ser Arg Leu Ser Val Leu Asn Ile Glu
                485                 490                 495     
Met Asn Phe Ile Leu Ser Pro Ser Leu Asp Phe Val Gln Ser Cys Gln
            500                 505                 510         
Glu Val Lys Thr Leu Asn Ala Gly Arg Asn Pro Phe Arg Cys Thr Cys
        515                 520                 525             
Glu Leu Lys Asn Phe Ile Gln Leu Glu Thr Tyr Ser Glu Val Met Met
    530                 535                 540                 
Val Gly Trp Ser Asp Ser Tyr Thr Cys Glu Tyr Pro Leu Asn Leu Arg
545                 550                 555                 560 
Gly Ile Arg Leu Lys Asp Val His Leu His Glu Leu Ser Cys Asn Thr
                565                 570                 575     
Ala Leu Leu Ile Val Thr Ile Val Val Ile Met Leu Val Leu Gly Leu
            580                 585                 590         
Ala Val Ala Phe Cys Cys Leu His Phe Asp Leu Pro Trp Tyr Leu Arg
        595                 600                 605             
Met Leu Gly Gln Cys Thr Gln Thr Trp His Arg Val Arg Lys Thr Thr
    610                 615                 620                 
Gln Glu Gln Leu Lys Arg Asn Val Arg Phe His Ala Phe Ile Ser Tyr
625                 630                 635                 640 
Ser Glu His Asp Ser Leu Trp Val Lys Asn Glu Leu Ile Pro Asn Leu
                645                 650                 655     
Glu Lys Glu Asp Gly Ser Ile Leu Ile Cys Leu Tyr Glu Ser Tyr Phe
            660                 665                 670         
Asp Pro Gly Lys Ser Ile Ser Glu Asn Ile Val Ser Phe Ile Glu Lys
        675                 680                 685             
Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro Asn Phe Val Gln Asn Glu
    690                 695                 700                 
Trp Cys His Tyr Glu Phe Tyr Phe Ala His His Asn Leu Phe His Glu
705                 710                 715                 720 
Asn Ser Asp His Ile Ile Leu Ile Leu Leu Glu Pro Ile Pro Phe Tyr
                725                 730                 735     
Cys Ile Pro Thr Arg Tyr His Lys Leu Lys Ala Leu Leu Glu Lys Lys
            740                 745                 750         
Ala Tyr Leu Glu Trp Pro Lys Asp Arg Arg Lys Cys Gly Leu Phe Trp
        755                 760                 765             
Ala Asn Leu Arg Ala Ala Ile Asn Val Asn Val Leu Ala Thr Arg Glu
    770                 775                 780                 
Met Tyr Glu Leu Gln Thr Phe Thr Glu Leu Asn Glu Glu Ser Arg Gly
785                 790                 795                 800 
Ser Thr Ile Ser Leu Met Arg Thr Asp Cys Leu
                805                 810     


<210> 1595
<211> 715
<212> PRT
<213> Homo sapiens

<400> 1595
Met Val Pro Gly Ser Glu Gly Pro Ala Arg Ala Gly Ser Val Val Ala
 1               5                  10                  15      
Asp Val Val Phe Val Ile Glu Gly Thr Ala Asn Leu Gly Pro Tyr Phe
            20                  25                  30          
Glu Gly Leu Arg Lys His Tyr Leu Leu Pro Ala Ile Glu Tyr Phe Asn
        35                  40                  45              
Gly Gly Pro Pro Ala Glu Thr Asp Phe Gly Gly Asp Tyr Gly Gly Thr
    50                  55                  60                  
Gln Tyr Ser Leu Val Val Phe Asn Thr Val Asp Cys Ala Pro Glu Ser
65                  70                  75                  80  
Tyr Val Gln Cys His Ala Pro Thr Ser Ser Ala Tyr Glu Phe Val Thr
                85                  90                  95      
Trp Leu Asp Gly Ile Lys Phe Met Gly Gly Gly Gly Glu Ser Cys Ser
            100                 105                 110         
Leu Ile Ala Glu Gly Leu Ser Thr Ala Leu Gln Leu Phe Asp Asp Phe
        115                 120                 125             
Lys Lys Met Arg Glu Gln Ile Gly Gln Thr His Arg Val Cys Leu Leu
    130                 135                 140                 
Ile Cys Asn Ser Pro Pro Tyr Leu Leu Pro Ala Val Glu Ser Thr Thr
145                 150                 155                 160 
Tyr Ser Gly Cys Thr Thr Glu Asn Leu Val Gln Gln Ile Gly Glu Arg
                165                 170                 175     
Gly Ile His Phe Ser Ile Val Ser Pro Arg Lys Leu Pro Ala Leu Arg
            180                 185                 190         
Leu Leu Phe Glu Lys Ala Ala Pro Pro Ala Leu Leu Glu Pro Leu Gln
        195                 200                 205             
Pro Pro Thr Asp Val Ser Gln Asp Pro Arg His Met Val Leu Val Arg
    210                 215                 220                 
Gly Leu Val Leu Pro Val Gly Gly Gly Ser Ala Leu Gly Pro Leu Gln
225                 230                 235                 240 
Ser Lys Gln Pro Val Pro Leu Pro Pro Ala Ala Pro Ser Gly Ala Thr
                245                 250                 255     
Leu Ser Ala Ala Pro Gln Gln Pro Leu Pro Pro Val Pro Pro Gln Tyr
            260                 265                 270         
Gln Val Pro Gly Asn Leu Ser Ala Ala Gln Val Ala Ala Gln Asn Ala
        275                 280                 285             
Val Glu Ala Ala Lys Asn Gln Lys Ala Gly Leu Gly Pro Arg Phe Ser
    290                 295                 300                 
Pro Ile Thr Pro Leu Gln Gln Ala Ala Pro Gly Val Gly Pro Pro Phe
305                 310                 315                 320 
Ser Gln Ala Pro Ala Pro Gln Leu Pro Pro Gly Pro Pro Gly Ala Pro
                325                 330                 335     
Lys Pro Pro Pro Ala Ser Gln Pro Ser Leu Val Ser Thr Val Ala Pro
            340                 345                 350         
Gly Ser Gly Leu Ala Pro Thr Ala Gln Pro Gly Ala Pro Ser Met Ala
        355                 360                 365             
Gly Thr Val Ala Pro Gly Gly Val Ser Gly Pro Ser Pro Ala Gln Leu
    370                 375                 380                 
Gly Ala Pro Ala Leu Gly Gly Gln Gln Ser Val Ser Asn Lys Leu Leu
385                 390                 395                 400 
Ala Trp Ser Gly Val Leu Glu Trp Gln Glu Lys Pro Lys Pro Ala Ser
                405                 410                 415     
Val Asp Ala Asn Thr Lys Leu Thr Arg Ser Leu Pro Cys Gln Val Tyr
            420                 425                 430         
Val Asn His Gly Glu Asn Leu Lys Thr Glu Gln Trp Pro Gln Lys Leu
        435                 440                 445             
Ile Met Gln Leu Ile Pro Gln Gln Leu Leu Thr Thr Leu Gly Pro Leu
    450                 455                 460                 
Phe Arg Asn Ser Arg Met Val Gln Phe His Phe Thr Asn Lys Asp Leu
465                 470                 475                 480 
Glu Ser Leu Lys Gly Leu Tyr Arg Ile Met Gly Asn Gly Phe Ala Gly
                485                 490                 495     
Cys Val His Phe Pro His Thr Ala Pro Cys Glu Val Arg Val Leu Met
            500                 505                 510         
Leu Leu Tyr Ser Ser Lys Lys Lys Ile Phe Met Gly Leu Ile Pro Tyr
        515                 520                 525             
Asp Gln Ser Gly Phe Val Asn Gly Ile Arg Gln Val Ile Thr Asn His
    530                 535                 540                 
Lys Gln Val Gln Gln Gln Lys Leu Glu Gln Gln Gln Arg Gly Met Gly
545                 550                 555                 560 
Gly Gln Gln Ala Pro Pro Arg Ala Gly Ala His Ser Gly Gly Pro Ser
                565                 570                 575     
Gln Ala Leu Thr Glu Ser Ala Pro Ala Pro Pro Thr Ala Ala Pro Ala
            580                 585                 590         
Ser Gly Tyr Arg Arg Gly Leu Trp Gly His Gly Ala Ala Pro Ala Pro
        595                 600                 605             
Arg Tyr Cys Pro Ala Pro Ala Arg Cys Pro Ser Arg Pro Ser Trp Ser
    610                 615                 620                 
Ser Phe Trp Pro Thr Pro Ser Trp Thr His Pro Ser Ala Pro Glu Pro
625                 630                 635                 640 
Trp Gly Gln Pro Ser Ala Ala Lys Pro Pro Pro Gln Pro Thr Thr Ala
                645                 650                 655     
Ala Asp Trp Gly Ala Pro Thr Pro Gly Leu Pro Pro Pro Pro Ala Gln
            660                 665                 670         
Ser Trp Pro Ala Gln Leu Pro Pro Arg Ala Pro Leu Pro Gly Lys Gly
        675                 680                 685             
Thr Arg Gly Arg Ala Glu Val Trp Thr Glu Cys Pro Ser Ser Ser Trp
    690                 695                 700                 
Ala Arg Ala Pro Arg Pro Ser Ala Pro Gly Lys
705                 710                 715 


<210> 1596
<211> 201
<212> PRT
<213> Homo sapiens

<400> 1596
Met Asn Pro Glu Tyr Asp Tyr Leu Phe Lys Leu Leu Leu Ile Gly Asp
 1               5                  10                  15      
Ser Gly Val Gly Lys Ser Cys Leu Leu Leu Arg Phe Ala Asp Asp Thr
            20                  25                  30          
Tyr Thr Glu Ser Tyr Ile Ser Thr Ile Gly Val Asp Phe Lys Ile Arg
        35                  40                  45              
Thr Ile Glu Leu Asp Gly Lys Thr Ile Lys Leu Gln Ile Trp Asp Thr
    50                  55                  60                  
Ala Gly Gln Glu Arg Phe Arg Thr Ile Thr Ser Ser Tyr Tyr Arg Gly
65                  70                  75                  80  
Ala His Gly Ile Ile Val Val Tyr Asp Val Thr Asp Gln Glu Ser Tyr
                85                  90                  95      
Ala Asn Val Lys Gln Trp Leu Gln Glu Ile Asp Arg Tyr Ala Ser Glu
            100                 105                 110         
Asn Val Asn Lys Leu Leu Val Gly Asn Lys Ser Asp Leu Thr Thr Lys
        115                 120                 125             
Lys Val Val Asp Asn Thr Thr Ala Lys Glu Phe Ala Asp Ser Leu Gly
    130                 135                 140                 
Ile Pro Phe Leu Glu Thr Ser Ala Lys Asn Ala Thr Asn Val Glu Gln
145                 150                 155                 160 
Ala Phe Met Thr Met Ala Ala Glu Ile Lys Lys Arg Met Gly Pro Gly
                165                 170                 175     
Ala Ala Ser Gly Gly Glu Arg Pro Asn Leu Lys Ile Asp Ser Thr Pro
            180                 185                 190         
Val Lys Pro Ala Gly Gly Gly Cys Cys
        195                 200     


<210> 1597
<211> 434
<212> PRT
<213> Homo sapiens

<400> 1597
Ala Lys Gln Gln Leu Asn Leu Arg Thr His Met Ala Asp Glu Asn Lys
 1               5                  10                  15      
Asn Glu Tyr Ala Ala Gln Leu Gln Asn Phe Asn Gly Glu Gln His Lys
            20                  25                  30          
His Phe Tyr Val Val Ile Pro Gln Ile Tyr Lys Gln Leu Gln Glu Met
        35                  40                  45              
Asp Glu Arg Arg Thr Ile Lys Leu Ser Glu Cys Tyr Arg Gly Phe Ala
    50                  55                  60                  
Asp Ser Glu Arg Lys Val Ile Pro Ile Ile Ser Lys Cys Leu Glu Gly
65                  70                  75                  80  
Met Ile Leu Ala Ala Lys Ser Val Asp Glu Arg Arg Asp Ser Gln Met
                85                  90                  95      
Val Val Asp Ser Phe Lys Ser Gly Phe Glu Pro Pro Gly Asp Phe Pro
            100                 105                 110         
Phe Glu Asp Tyr Ser Gln His Ile Tyr Arg Thr Ile Ser Asp Gly Thr
        115                 120                 125             
Ile Ser Ala Ser Lys Gln Glu Ser Gly Lys Met Asp Ala Lys Thr Thr
    130                 135                 140                 
Val Gly Lys Ala Lys Gly Lys Leu Trp Leu Phe Gly Lys Lys Pro Lys
145                 150                 155                 160 
Pro Gln Ser Pro Pro Leu Thr Pro Thr Ser Leu Phe Thr Ser Ser Thr
                165                 170                 175     
Pro Asn Gly Ser Gln Phe Leu Thr Phe Ser Ile Glu Pro Val His Tyr
            180                 185                 190         
Cys Met Asn Glu Ile Lys Thr Gly Lys Pro Arg Ile Pro Ser Phe Arg
        195                 200                 205             
Ser Leu Lys Arg Gly Gly Pro Ala Leu Glu Asp Phe Ser His Leu Pro
    210                 215                 220                 
Pro Glu Gln Arg Arg Lys Lys Leu Gln Gln Arg Ile Asp Glu Leu Asn
225                 230                 235                 240 
Arg Glu Leu Gln Lys Glu Ser Asp Gln Lys Asp Ala Leu Asn Lys Met
                245                 250                 255     
Lys Asp Val Tyr Glu Lys Asn Pro Gln Met Gly Asp Pro Gly Ser Leu
            260                 265                 270         
Gln Pro Lys Leu Ala Glu Thr Met Asn Asn Ile Asp Arg Leu Arg Met
        275                 280                 285             
Glu Ile His Lys Asn Glu Ala Trp Leu Ser Glu Val Glu Gly Lys Thr
    290                 295                 300                 
Gly Gly Arg Gly Asp Arg Arg His Ser Ser Asp Ile Asn His Leu Val
305                 310                 315                 320 
Thr Gln Gly Arg Glu Ser Pro Glu Gly Ser Tyr Thr Asp Asp Ala Asn
                325                 330                 335     
Gln Glu Val Arg Gly Pro Pro Gln Gln His Gly His His Asn Glu Phe
            340                 345                 350         
Asp Asp Glu Phe Glu Asp Asp Asp Pro Leu Pro Ala Ile Gly His Cys
        355                 360                 365             
Lys Ala Ile Tyr Pro Phe Asp Gly His Asn Glu Gly Thr Leu Ala Met
    370                 375                 380                 
Lys Glu Gly Glu Val Leu Tyr Ile Ile Glu Glu Asp Lys Gly Asp Gly
385                 390                 395                 400 
Trp Thr Arg Ala Arg Arg Gln Asn Gly Glu Glu Gly Tyr Val Pro Thr
                405                 410                 415     
Ser Tyr Ile Asp Val Thr Leu Glu Lys Asn Ser Lys Gly Ala Val Thr
            420                 425                 430         
Tyr Ile
        


<210> 1598
<211> 4097
<212> PRT
<213> Homo sapiens

<400> 1598
Met Ala Gly Ser Gly Ala Gly Val Arg Cys Ser Leu Leu Arg Leu Gln
 1               5                  10                  15      
Glu Thr Leu Ser Ala Ala Asp Arg Cys Gly Ala Ala Leu Ala Gly His
            20                  25                  30          
Gln Leu Ile Arg Gly Leu Gly Gln Glu Cys Val Leu Ser Ser Ser Pro
        35                  40                  45              
Ala Val Leu Ala Leu Gln Thr Ser Leu Val Phe Ser Arg Asp Phe Gly
    50                  55                  60                  
Leu Leu Val Phe Val Arg Lys Ser Leu Asn Ser Ile Glu Phe Arg Glu
65                  70                  75                  80  
Cys Arg Glu Glu Ile Leu Lys Phe Leu Cys Ile Phe Leu Glu Lys Met
                85                  90                  95      
Gly Gln Lys Ile Ala Pro Tyr Ser Val Glu Ile Lys Asn Thr Cys Thr
            100                 105                 110         
Ser Val Tyr Thr Lys Asp Arg Ala Ala Lys Cys Lys Ile Pro Ala Leu
        115                 120                 125             
Asp Leu Leu Ile Lys Leu Leu Gln Thr Phe Arg Ser Ser Arg Leu Met
    130                 135                 140                 
Asp Glu Phe Lys Ile Gly Glu Leu Phe Ser Lys Phe Tyr Gly Glu Leu
145                 150                 155                 160 
Ala Leu Lys Lys Lys Ile Pro Asp Thr Val Leu Glu Lys Val Tyr Glu
                165                 170                 175     
Leu Leu Gly Leu Leu Gly Glu Val His Pro Ser Glu Met Ile Asn Asn
            180                 185                 190         
Ala Glu Asn Leu Phe Arg Ala Phe Leu Gly Glu Leu Lys Thr Gln Met
        195                 200                 205             
Thr Ser Ala Val Arg Glu Pro Lys Leu Pro Val Leu Ala Gly Cys Leu
    210                 215                 220                 
Lys Gly Leu Ser Ser Leu Leu Cys Asn Phe Thr Lys Ser Met Glu Glu
225                 230                 235                 240 
Asp Pro Gln Thr Ser Arg Glu Ile Phe Asn Phe Val Leu Lys Ala Ile
                245                 250                 255     
Arg Pro Gln Ile Asp Leu Lys Arg Tyr Ala Val Pro Ser Ala Gly Leu
            260                 265                 270         
Arg Leu Phe Ala Leu His Ala Ser Gln Phe Ser Thr Cys Leu Leu Asp
        275                 280                 285             
Asn Tyr Val Ser Leu Phe Glu Val Leu Leu Lys Trp Cys Ala His Thr
    290                 295                 300                 
Asn Val Glu Leu Lys Lys Ala Ala Leu Ser Ala Leu Glu Ser Phe Leu
305                 310                 315                 320 
Lys Gln Val Ser Asn Met Val Ala Lys Asn Ala Glu Met His Lys Asn
                325                 330                 335     
Lys Leu Gln Tyr Phe Met Glu Gln Phe Tyr Gly Ile Ile Arg Asn Val
            340                 345                 350         
Asp Ser Asn Asn Lys Glu Leu Ser Ile Ala Ile Arg Gly Tyr Gly Leu
        355                 360                 365             
Phe Ala Gly Pro Cys Lys Val Ile Asn Ala Lys Asp Val Asp Phe Met
    370                 375                 380                 
Tyr Val Glu Leu Ile Gln Arg Cys Lys Gln Met Phe Leu Thr Gln Thr
385                 390                 395                 400 
Asp Thr Gly Asp Tyr Arg Val Tyr Gln Met Pro Ser Phe Leu Gln Ser
                405                 410                 415     
Val Ala Ser Val Leu Leu Tyr Leu Asp Thr Val Pro Glu Val Tyr Thr
            420                 425                 430         
Pro Val Leu Glu His Leu Val Val Met Gln Ile Asp Ser Phe Pro Gln
        435                 440                 445             
Tyr Ser Pro Lys Met Gln Leu Val Cys Cys Arg Ala Ile Val Lys Val
    450                 455                 460                 
Phe Leu Ala Leu Ala Ala Lys Gly Pro Val Leu Arg Asn Cys Ile Ser
465                 470                 475                 480 
Thr Val Val His Gln Gly Leu Ile Arg Ile Cys Ser Lys Pro Val Val
                485                 490                 495     
Leu Pro Lys Gly Pro Glu Ser Glu Ser Glu Asp His Arg Ala Ser Gly
            500                 505                 510         
Glu Val Arg Thr Gly Lys Trp Lys Val Pro Thr Tyr Lys Asp Tyr Val
        515                 520                 525             
Asp Leu Phe Arg His Leu Leu Ser Ser Asp Gln Met Met Asp Ser Ile
    530                 535                 540                 
Leu Ala Asp Glu Ala Phe Phe Ser Val Asn Ser Ser Ser Glu Ser Leu
545                 550                 555                 560 
Asn His Leu Leu Tyr Asp Glu Phe Val Lys Ser Val Leu Lys Ile Val
                565                 570                 575     
Glu Lys Leu Asp Leu Thr Leu Glu Ile Gln Thr Val Gly Glu Gln Glu
            580                 585                 590         
Asn Gly Asp Glu Ala Pro Gly Val Trp Met Ile Pro Thr Ser Asp Pro
        595                 600                 605             
Ala Ala Asn Leu His Pro Ala Lys Pro Lys Asp Phe Ser Ala Phe Ile
    610                 615                 620                 
Asn Leu Val Glu Phe Cys Arg Glu Ile Leu Pro Glu Lys Gln Ala Glu
625                 630                 635                 640 
Phe Phe Glu Pro Trp Val Tyr Ser Phe Ser Tyr Glu Leu Ile Leu Gln
                645                 650                 655     
Ser Thr Arg Leu Pro Leu Ile Ser Gly Phe Tyr Lys Leu Leu Ser Ile
            660                 665                 670         
Thr Val Arg Asn Ala Lys Lys Ile Lys Tyr Phe Glu Gly Val Ser Pro
        675                 680                 685             
Lys Ser Leu Lys His Ser Pro Glu Asp Pro Glu Lys Tyr Ser Cys Phe
    690                 695                 700                 
Ala Leu Phe Val Lys Phe Gly Lys Glu Val Ala Val Lys Met Lys Gln
705                 710                 715                 720 
Tyr Lys Asp Glu Leu Leu Ala Ser Cys Leu Thr Phe Leu Leu Ser Leu
                725                 730                 735     
Pro His Asn Ile Ile Glu Leu Asp Val Arg Ala Tyr Val Pro Ala Leu
            740                 745                 750         
Gln Met Ala Phe Lys Leu Gly Leu Ser Tyr Thr Pro Leu Ala Glu Val
        755                 760                 765             
Gly Leu Asn Ala Leu Glu Glu Trp Ser Ile Tyr Ile Asp Arg His Val
    770                 775                 780                 
Met Gln Pro Tyr Tyr Lys Asp Ile Leu Pro Cys Leu Asp Gly Tyr Leu
785                 790                 795                 800 
Lys Thr Ser Ala Leu Ser Asp Glu Thr Lys Asn Asn Trp Glu Val Ser
                805                 810                 815     
Ala Leu Ser Arg Ala Ala Gln Lys Gly Phe Asn Lys Val Val Leu Lys
            820                 825                 830         
His Leu Lys Lys Thr Lys Asn Leu Ser Ser Asn Glu Ala Ile Ser Leu
        835                 840                 845             
Glu Glu Ile Arg Ile Arg Val Val Gln Met Leu Gly Ser Leu Gly Gly
    850                 855                 860                 
Gln Ile Asn Lys Asn Leu Leu Thr Val Thr Ser Ser Asp Glu Met Met
865                 870                 875                 880 
Lys Ser Tyr Val Ala Trp Asp Arg Glu Lys Arg Leu Ser Phe Ala Val
                885                 890                 895     
Pro Phe Arg Glu Met Lys Pro Val Ile Phe Leu Asp Val Phe Leu Pro
            900                 905                 910         
Arg Val Thr Glu Leu Ala Leu Thr Ala Ser Asp Arg Gln Thr Lys Val
        915                 920                 925             
Ala Ala Cys Glu Leu Leu His Ser Met Val Met Phe Met Leu Gly Lys
    930                 935                 940                 
Ala Thr Gln Met Pro Glu Gly Gly Gln Gly Ala Pro Pro Met Tyr Gln
945                 950                 955                 960 
Leu Tyr Lys Arg Thr Phe Pro Val Leu Leu Arg Leu Ala Cys Asp Val
                965                 970                 975     
Asp Gln Val Thr Arg Gln Leu Tyr Glu Pro Leu Val Met Gln Leu Ile
            980                 985                 990         
His Trp Phe Thr Asn Asn Lys Lys Phe Glu Ser Gln Asp Thr Val Ser
        995                 1000                1005            
Leu Leu Glu Ala Ile Leu Asp Gly Ile Val Asp Pro Val Asp Ser Thr
    1010                1015                1020                
Leu Arg Asp Phe Cys Gly Arg Cys Ile Arg Glu Phe Leu Lys Trp Ser
1025                1030                1035                1040
Ile Lys Gln Ile Thr Pro Gln Gln Gln Glu Lys Ser Pro Val Asn Thr
                1045                1050                1055    
Lys Ser Leu Phe Lys Arg Leu Tyr Ser Leu Ala Leu His Pro Asn Ala
            1060                1065                1070        
Phe Lys Arg Leu Gly Ala Ser Leu Ala Phe Asn Asn Ile Tyr Arg Glu
        1075                1080                1085            
Phe Arg Glu Glu Glu Ser Leu Val Glu Gln Phe Val Phe Glu Ala Leu
    1090                1095                1100                
Val Ile Tyr Met Glu Ser Leu Ala Leu Ala His Ala Asp Glu Lys Ser
1105                1110                1115                1120
Leu Gly Thr Ile Gln Gln Cys Cys Asp Ala Ile Asp His Leu Cys Arg
                1125                1130                1135    
Ile Ile Glu Lys Lys His Val Ser Leu Asn Lys Ala Lys Lys Arg Arg
            1140                1145                1150        
Leu Pro Arg Gly Phe Pro Pro Ser Ala Ser Leu Cys Leu Leu Asp Leu
        1155                1160                1165            
Val Lys Trp Leu Leu Ala His Cys Gly Arg Pro Gln Thr Glu Cys Arg
    1170                1175                1180                
His Lys Ser Ile Glu Leu Phe Tyr Lys Phe Val Pro Leu Leu Pro Gly
1185                1190                1195                1200
Asn Arg Ser Pro Asn Leu Trp Leu Lys Asp Val Leu Lys Glu Glu Gly
                1205                1210                1215    
Val Ser Phe Leu Ile Asn Thr Phe Glu Gly Gly Gly Cys Gly Gln Pro
            1220                1225                1230        
Ser Gly Ile Leu Ala Gln Pro Thr Leu Leu Tyr Leu Arg Gly Pro Phe
        1235                1240                1245            
Ser Leu Gln Ala Thr Leu Cys Trp Leu Asp Leu Leu Leu Ala Ala Leu
    1250                1255                1260                
Glu Cys Tyr Asn Thr Phe Ile Gly Glu Arg Thr Val Gly Ala Leu Gln
1265                1270                1275                1280
Val Leu Gly Thr Glu Ala Gln Ser Ser Leu Leu Lys Ala Val Ala Phe
                1285                1290                1295    
Phe Leu Glu Ser Ile Ala Met His Asp Ile Ile Ala Ala Glu Lys Cys
            1300                1305                1310        
Phe Gly Thr Gly Ala Ala Gly Asn Arg Thr Ser Pro Gln Glu Gly Glu
        1315                1320                1325            
Arg Tyr Asn Tyr Ser Lys Cys Thr Val Val Val Arg Ile Met Glu Phe
    1330                1335                1340                
Thr Thr Thr Leu Leu Asn Thr Ser Pro Glu Gly Trp Lys Leu Leu Lys
1345                1350                1355                1360
Lys Asp Leu Cys Asn Thr His Leu Met Arg Val Leu Val Gln Thr Leu
                1365                1370                1375    
Cys Glu Pro Ala Ser Ile Gly Phe Asn Ile Gly Asp Val Gln Val Met
            1380                1385                1390        
Ala His Leu Pro Asp Val Cys Val Asn Leu Met Lys Ala Leu Lys Met
        1395                1400                1405            
Ser Pro Tyr Lys Asp Ile Leu Glu Thr His Leu Arg Glu Lys Ile Thr
    1410                1415                1420                
Ala Gln Ser Ile Glu Glu Leu Cys Ala Val Asn Leu Tyr Gly Pro Asp
1425                1430                1435                1440
Ala Gln Val Asp Arg Ser Arg Leu Ala Ala Val Val Ser Ala Cys Lys
                1445                1450                1455    
Gln Leu His Arg Ala Gly Leu Leu His Asn Ile Leu Pro Ser Gln Ser
            1460                1465                1470        
Thr Asp Leu His His Ser Val Gly Thr Glu Leu Leu Ser Leu Val Tyr
        1475                1480                1485            
Lys Gly Ile Ala Pro Gly Asp Glu Arg Gln Cys Leu Pro Ser Leu Asp
    1490                1495                1500                
Leu Ser Cys Lys Gln Leu Ala Ser Gly Leu Leu Glu Leu Ala Phe Ala
1505                1510                1515                1520
Phe Gly Gly Leu Cys Glu Arg Leu Val Ser Leu Leu Leu Asn Pro Ala
                1525                1530                1535    
Val Leu Ser Thr Ala Ser Leu Gly Ser Ser Gln Gly Ser Val Ile His
            1540                1545                1550        
Phe Ser His Gly Glu Tyr Phe Tyr Ser Leu Phe Ser Glu Thr Ile Asn
        1555                1560                1565            
Thr Glu Leu Leu Lys Asn Leu Asp Leu Ala Val Leu Glu Leu Met Gln
    1570                1575                1580                
Ser Ser Val Asp Asn Thr Lys Met Val Ser Ala Val Leu Asn Gly Met
1585                1590                1595                1600
Leu Asp Gln Ser Phe Arg Glu Arg Ala Asn Gln Lys His Gln Gly Leu
                1605                1610                1615    
Lys Leu Ala Thr Thr Ile Leu Gln His Trp Lys Lys Cys Asp Ser Trp
            1620                1625                1630        
Trp Ala Lys Asp Ser Pro Leu Glu Thr Lys Met Ala Val Leu Ala Leu
        1635                1640                1645            
Leu Ala Lys Ile Leu Gln Ile Asp Ser Ser Val Ser Phe Asn Thr Ser
    1650                1655                1660                
His Gly Ser Phe Pro Glu Val Phe Thr Thr Tyr Ile Ser Leu Leu Ala
1665                1670                1675                1680
Asp Thr Lys Leu Asp Leu His Leu Lys Gly Gln Ala Val Thr Leu Leu
                1685                1690                1695    
Pro Phe Phe Thr Ser Leu Thr Gly Gly Ser Leu Glu Glu Leu Arg Arg
            1700                1705                1710        
Val Leu Glu Gln Leu Ile Val Ala His Phe Pro Met Gln Ser Arg Glu
        1715                1720                1725            
Phe Pro Pro Gly Thr Pro Arg Phe Asn Asn Tyr Val Asp Cys Met Lys
    1730                1735                1740                
Lys Phe Leu Asp Ala Leu Glu Leu Ser Gln Ser Pro Met Leu Leu Glu
1745                1750                1755                1760
Leu Met Thr Glu Val Leu Cys Arg Glu Gln Gln His Val Met Glu Glu
                1765                1770                1775    
Leu Phe Gln Ser Ser Phe Arg Arg Ile Ala Arg Arg Gly Ser Cys Val
            1780                1785                1790        
Thr Gln Val Gly Leu Leu Glu Ser Val Tyr Glu Met Phe Arg Lys Asp
        1795                1800                1805            
Asp Pro Arg Leu Ser Phe Thr Arg Gln Ser Phe Val Asp Arg Ser Leu
    1810                1815                1820                
Leu Thr Leu Leu Trp His Cys Ser Leu Asp Ala Leu Arg Glu Phe Phe
1825                1830                1835                1840
Ser Thr Ile Val Val Asp Ala Ile Asp Val Leu Lys Ser Arg Phe Thr
                1845                1850                1855    
Lys Leu Asn Glu Ser Thr Phe Asp Thr Gln Ile Thr Lys Lys Met Gly
            1860                1865                1870        
Tyr Tyr Lys Ile Leu Asp Val Met Tyr Ser Arg Leu Pro Lys Asp Asp
        1875                1880                1885            
Val His Ala Lys Glu Ser Lys Ile Asn Gln Val Phe His Gly Ser Cys
    1890                1895                1900                
Ile Thr Glu Gly Asn Glu Leu Thr Lys Thr Leu Ile Lys Leu Cys Tyr
1905                1910                1915                1920
Asp Ala Phe Thr Glu Asn Met Ala Gly Glu Asn Gln Leu Leu Glu Arg
                1925                1930                1935    
Arg Arg Leu Tyr His Cys Ala Ala Tyr Asn Cys Ala Ile Ser Val Ile
            1940                1945                1950        
Cys Cys Val Phe Asn Glu Leu Lys Phe Tyr Gln Gly Phe Leu Phe Ser
        1955                1960                1965            
Glu Lys Pro Glu Lys Asn Leu Leu Ile Phe Glu Asn Leu Ile Asp Leu
    1970                1975                1980                
Lys Arg Arg Tyr Asn Phe Pro Val Glu Val Glu Val Pro Met Glu Arg
1985                1990                1995                2000
Lys Lys Lys Tyr Ile Glu Ile Arg Lys Glu Ala Arg Glu Ala Ala Asn
                2005                2010                2015    
Gly Asp Ser Asp Gly Pro Ser Tyr Met Ser Ser Leu Ser Tyr Leu Ala
            2020                2025                2030        
Asp Ser Thr Leu Ser Glu Glu Met Ser Gln Phe Asp Phe Ser Thr Gly
        2035                2040                2045            
Val Gln Ser Tyr Ser Tyr Ser Ser Gln Asp Pro Arg Pro Ala Thr Gly
    2050                2055                2060                
Arg Phe Arg Arg Arg Glu Gln Arg Asp Pro Thr Val His Asp Asp Val
2065                2070                2075                2080
Leu Glu Leu Glu Met Asp Glu Leu Asn Arg His Glu Cys Met Ala Pro
                2085                2090                2095    
Leu Thr Ala Leu Val Lys His Met His Arg Ser Leu Gly Pro Pro Gln
            2100                2105                2110        
Gly Glu Glu Asp Ser Val Pro Arg Asp Leu Pro Ser Trp Met Lys Phe
        2115                2120                2125            
Leu His Gly Lys Leu Gly Asn Pro Ile Val Pro Leu Asn Ile Arg Leu
    2130                2135                2140                
Phe Leu Ala Lys Leu Val Ile Asn Thr Glu Glu Val Phe Arg Pro Tyr
2145                2150                2155                2160
Ala Lys His Trp Leu Ser Pro Leu Leu Gln Leu Ala Ala Ser Glu Asn
                2165                2170                2175    
Asn Gly Gly Glu Gly Ile His Tyr Met Val Val Glu Ile Val Ala Thr
            2180                2185                2190        
Ile Leu Ser Trp Thr Gly Leu Ala Thr Pro Thr Gly Val Pro Lys Asp
        2195                2200                2205            
Glu Val Leu Ala Asn Arg Leu Leu Asn Phe Leu Met Lys His Val Phe
    2210                2215                2220                
His Pro Lys Arg Ala Val Phe Arg His Asn Leu Glu Ile Ile Lys Thr
2225                2230                2235                2240
Leu Val Glu Cys Trp Lys Asp Cys Leu Ser Ile Pro Tyr Arg Leu Ile
                2245                2250                2255    
Phe Glu Lys Phe Ser Gly Lys Asp Pro Asn Ser Lys Asp Asn Ser Val
            2260                2265                2270        
Gly Ile Gln Leu Leu Gly Ile Val Met Ala Asn Asp Leu Pro Pro Tyr
        2275                2280                2285            
Asp Pro Gln Cys Gly Ile Gln Ser Ser Glu Tyr Phe Gln Ala Leu Val
    2290                2295                2300                
Asn Asn Met Ser Phe Val Arg Tyr Lys Glu Val Tyr Ala Ala Ala Ala
2305                2310                2315                2320
Glu Val Leu Gly Leu Ile Leu Arg Tyr Val Met Glu Arg Lys Asn Ile
                2325                2330                2335    
Leu Glu Glu Ser Leu Cys Glu Leu Val Ala Lys Gln Leu Lys Gln His
            2340                2345                2350        
Gln Asn Thr Met Glu Asp Lys Phe Ile Val Cys Leu Asn Lys Val Thr
        2355                2360                2365            
Lys Ser Phe Pro Pro Leu Ala Asp Arg Phe Met Asn Ala Val Phe Phe
    2370                2375                2380                
Leu Leu Pro Lys Phe His Gly Val Leu Lys Thr Leu Cys Leu Glu Val
2385                2390                2395                2400
Val Leu Cys Arg Val Glu Gly Met Thr Glu Leu Tyr Phe Gln Leu Lys
                2405                2410                2415    
Ser Lys Asp Phe Val Gln Val Met Arg His Arg Asp Asp Glu Arg Gln
            2420                2425                2430        
Lys Val Cys Leu Asp Ile Ile Tyr Lys Met Met Pro Lys Leu Lys Pro
        2435                2440                2445            
Val Glu Leu Arg Glu Leu Leu Asn Pro Val Val Glu Phe Val Ser His
    2450                2455                2460                
Pro Ser Thr Thr Cys Arg Glu Gln Met Tyr Asn Ile Leu Met Trp Ile
2465                2470                2475                2480
His Asp Asn Tyr Arg Asp Pro Glu Ser Glu Thr Asp Asn Asp Ser Gln
                2485                2490                2495    
Glu Ile Phe Lys Leu Ala Lys Asp Val Leu Ile Gln Gly Leu Ile Asp
            2500                2505                2510        
Glu Asn Pro Gly Leu Gln Leu Ile Ile Arg Asn Phe Trp Ser His Glu
        2515                2520                2525            
Thr Arg Leu Pro Ser Asn Thr Leu Asp Arg Leu Leu Ala Leu Asn Ser
    2530                2535                2540                
Leu Tyr Ser Pro Lys Ile Glu Val His Phe Leu Ser Leu Ala Thr Asn
2545                2550                2555                2560
Phe Leu Leu Glu Met Thr Ser Met Ser Pro Asp Tyr Pro Asn Pro Met
                2565                2570                2575    
Phe Glu His Pro Leu Ser Glu Cys Glu Phe Gln Glu Tyr Thr Ile Asp
            2580                2585                2590        
Ser Asp Trp Arg Phe Arg Ser Thr Val Leu Thr Pro Met Phe Val Glu
        2595                2600                2605            
Thr Gln Ala Ser Gln Gly Thr Leu Gln Thr Arg Thr Gln Glu Gly Ser
    2610                2615                2620                
Leu Ser Ala Arg Trp Pro Val Ala Gly Gln Ile Arg Ala Thr Gln Gln
2625                2630                2635                2640
Gln His Asp Phe Thr Leu Thr Gln Thr Ala Asp Gly Arg Ser Ser Phe
                2645                2650                2655    
Asp Trp Leu Thr Gly Ser Ser Thr Asp Pro Leu Val Asp His Thr Ser
            2660                2665                2670        
Pro Ser Ser Asp Ser Leu Leu Phe Ala His Lys Arg Ser Glu Arg Leu
        2675                2680                2685            
Gln Arg Ala Pro Leu Lys Ser Val Gly Pro Asp Phe Gly Lys Lys Arg
    2690                2695                2700                
Leu Gly Leu Pro Gly Asp Glu Val Asp Asn Lys Val Lys Gly Ala Ala
2705                2710                2715                2720
Gly Arg Thr Asp Leu Leu Arg Leu Arg Arg Arg Phe Met Arg Asp Gln
                2725                2730                2735    
Glu Lys Leu Ser Leu Met Tyr Ala Arg Lys Gly Val Ala Glu Gln Lys
            2740                2745                2750        
Arg Glu Lys Glu Ile Lys Ser Glu Leu Lys Met Lys Gln Asp Ala Gln
        2755                2760                2765            
Val Val Leu Tyr Arg Ser Tyr Arg His Gly Asp Leu Pro Asp Ile Gln
    2770                2775                2780                
Ile Lys His Ser Ser Leu Ile Thr Pro Leu Gln Ala Val Ala Gln Arg
2785                2790                2795                2800
Asp Pro Ile Ile Ala Lys Gln Leu Phe Ser Ser Leu Phe Ser Gly Ile
                2805                2810                2815    
Leu Lys Glu Met Asp Lys Phe Lys Thr Leu Ser Glu Lys Asn Asn Ile
            2820                2825                2830        
Thr Gln Lys Leu Leu Gln Asp Phe Asn Arg Phe Leu Asn Thr Thr Phe
        2835                2840                2845            
Ser Phe Phe Pro Pro Phe Val Ser Cys Ile Gln Asp Ile Ser Cys Gln
    2850                2855                2860                
His Ala Ala Leu Leu Ser Leu Asp Pro Ala Ala Val Ser Ala Gly Cys
2865                2870                2875                2880
Leu Ala Ser Leu Gln Gln Pro Val Gly Ile Arg Leu Leu Glu Glu Ala
                2885                2890                2895    
Leu Leu Arg Leu Leu Pro Ala Glu Leu Pro Ala Lys Arg Val Arg Gly
            2900                2905                2910        
Lys Ala Arg Leu Pro Pro Asp Val Leu Arg Trp Val Glu Leu Ala Lys
        2915                2920                2925            
Leu Tyr Arg Ser Ile Gly Glu Tyr Asp Val Leu Arg Gly Ile Phe Thr
    2930                2935                2940                
Ser Glu Ile Gly Thr Lys Gln Ile Thr Gln Ser Ala Leu Leu Ala Glu
2945                2950                2955                2960
Ala Arg Ser Asp Tyr Ser Glu Ala Ala Lys Gln Tyr Asp Glu Ala Leu
                2965                2970                2975    
Asn Lys Gln Asp Trp Val Asp Gly Glu Pro Thr Glu Ala Glu Lys Asp
            2980                2985                2990        
Phe Trp Glu Leu Ala Ser Leu Asp Cys Tyr Asn His Leu Ala Glu Trp
        2995                3000                3005            
Lys Ser Leu Glu Tyr Cys Ser Thr Ala Ser Ile Asp Ser Glu Asn Pro
    3010                3015                3020                
Pro Asp Leu Asn Lys Ile Trp Ser Glu Pro Phe Tyr Gln Glu Thr Tyr
3025                3030                3035                3040
Leu Pro Tyr Met Ile Arg Ser Lys Leu Lys Leu Leu Leu Gln Gly Glu
                3045                3050                3055    
Ala Asp Gln Ser Leu Leu Thr Phe Ile Asp Lys Ala Met His Gly Glu
            3060                3065                3070        
Leu Gln Lys Ala Ile Leu Glu Leu His Tyr Ser Gln Glu Leu Ser Leu
        3075                3080                3085            
Leu Tyr Leu Leu Gln Asp Asp Val Asp Arg Ala Lys Tyr Tyr Ile Gln
    3090                3095                3100                
Asn Gly Ile Gln Ser Phe Met Gln Asn Tyr Ser Ser Ile Asp Val Leu
3105                3110                3115                3120
Leu His Gln Ser Arg Leu Thr Lys Leu Gln Ser Val Gln Ala Leu Thr
                3125                3130                3135    
Glu Ile Gln Glu Phe Ile Ser Phe Ile Ser Lys Gln Gly Asn Leu Ser
            3140                3145                3150        
Ser Gln Val Pro Leu Lys Arg Leu Leu Asn Thr Trp Thr Asn Arg Tyr
        3155                3160                3165            
Pro Asp Ala Lys Met Asp Pro Met Asn Ile Trp Asp Asp Ile Ile Thr
    3170                3175                3180                
Asn Arg Cys Phe Phe Leu Ser Lys Ile Glu Glu Lys Leu Thr Pro Leu
3185                3190                3195                3200
Pro Glu Asp Asn Ser Met Asn Val Asp Gln Asp Gly Asp Pro Ser Asp
                3205                3210                3215    
Arg Met Glu Val Gln Glu Gln Glu Glu Asp Ile Ser Ser Leu Ile Arg
            3220                3225                3230        
Ser Cys Lys Phe Ser Met Lys Met Lys Met Ile Asp Ser Ala Arg Lys
        3235                3240                3245            
Gln Asn Asn Phe Ser Leu Ala Met Lys Leu Leu Lys Glu Leu His Lys
    3250                3255                3260                
Glu Ser Lys Thr Arg Asp Asp Trp Leu Val Ser Trp Val Gln Ser Tyr
3265                3270                3275                3280
Cys Arg Leu Ser His Cys Arg Ser Arg Ser Gln Gly Cys Ser Glu Gln
                3285                3290                3295    
Val Leu Thr Val Leu Lys Thr Val Ser Leu Leu Asp Glu Asn Asn Val
            3300                3305                3310        
Ser Ser Tyr Leu Ser Lys Asn Ile Leu Ala Phe Arg Asp Gln Asn Ile
        3315                3320                3325            
Leu Leu Gly Thr Thr Tyr Arg Ile Ile Ala Asn Ala Leu Ser Ser Glu
    3330                3335                3340                
Pro Ala Cys Leu Ala Glu Ile Glu Glu Asp Lys Ala Arg Arg Ile Leu
3345                3350                3355                3360
Glu Leu Ser Gly Ser Ser Ser Glu Asp Ser Glu Lys Val Ile Ala Gly
                3365                3370                3375    
Leu Tyr Gln Arg Ala Phe Gln His Leu Ser Glu Ala Val Gln Ala Ala
            3380                3385                3390        
Glu Glu Glu Ala Gln Pro Pro Ser Trp Ser Cys Gly Pro Ala Ala Gly
        3395                3400                3405            
Val Ile Asp Ala Tyr Met Thr Leu Ala Asp Phe Cys Asp Gln Gln Leu
    3410                3415                3420                
Arg Lys Glu Glu Glu Asn Ala Ser Val Ile Asp Ser Ala Glu Leu Gln
3425                3430                3435                3440
Ala Tyr Pro Ala Leu Val Val Glu Lys Met Leu Lys Ala Leu Lys Leu
                3445                3450                3455    
Asn Ser Asn Glu Ala Arg Leu Lys Phe Pro Arg Leu Leu Gln Ile Ile
            3460                3465                3470        
Glu Arg Tyr Pro Glu Glu Thr Leu Ser Leu Met Thr Lys Glu Ile Ser
        3475                3480                3485            
Ser Val Pro Cys Trp Gln Phe Ile Ser Trp Ile Ser His Met Val Ala
    3490                3495                3500                
Leu Leu Asp Lys Asp Gln Ala Val Ala Val Gln His Ser Val Glu Glu
3505                3510                3515                3520
Ile Thr Asp Asn Tyr Pro Gln Ala Ile Val Tyr Pro Phe Ile Ile Ser
                3525                3530                3535    
Ser Glu Ser Tyr Ser Phe Lys Asp Thr Ser Thr Gly His Lys Asn Lys
            3540                3545                3550        
Glu Phe Val Ala Arg Ile Lys Ser Lys Leu Asp Gln Gly Gly Val Ile
        3555                3560                3565            
Gln Asp Phe Ile Asn Ala Leu Asp Gln Leu Ser Asn Pro Glu Leu Leu
    3570                3575                3580                
Phe Lys Asp Trp Ser Asn Asp Val Arg Ala Glu Leu Ala Lys Thr Pro
3585                3590                3595                3600
Val Asn Lys Lys Asn Ile Glu Lys Met Tyr Glu Arg Met Tyr Ala Ala
                3605                3610                3615    
Leu Gly Asp Pro Lys Ala Pro Gly Leu Gly Ala Phe Arg Arg Lys Phe
            3620                3625                3630        
Ile Gln Thr Phe Gly Lys Glu Phe Asp Lys His Phe Gly Lys Gly Gly
        3635                3640                3645            
Ser Lys Leu Leu Arg Met Lys Leu Ser Asp Phe Asn Asp Ile Thr Asn
    3650                3655                3660                
Met Leu Leu Leu Lys Met Asn Lys Asp Ser Lys Pro Pro Gly Asn Leu
3665                3670                3675                3680
Lys Glu Cys Ser Pro Trp Met Ser Asp Phe Lys Val Glu Phe Leu Arg
                3685                3690                3695    
Asn Glu Leu Glu Ile Pro Gly Gln Tyr Asp Gly Arg Gly Lys Pro Leu
            3700                3705                3710        
Pro Glu Tyr His Val Arg Ile Ala Gly Phe Asp Glu Arg Val Thr Val
        3715                3720                3725            
Met Ala Ser Leu Arg Arg Pro Lys Arg Ile Ile Ile Arg Gly His Asp
    3730                3735                3740                
Glu Arg Glu His Pro Phe Leu Val Lys Gly Gly Glu Asp Leu Arg Gln
3745                3750                3755                3760
Asp Gln Arg Val Glu Gln Leu Phe Gln Val Met Asn Gly Ile Leu Ala
                3765                3770                3775    
Gln Asp Ser Ala Cys Ser Gln Arg Ala Leu Gln Leu Arg Thr Tyr Ser
            3780                3785                3790        
Val Val Pro Met Thr Ser Ser Asp Pro Arg Ala Pro Pro Cys Glu Tyr
        3795                3800                3805            
Lys Asp Trp Leu Thr Lys Met Ser Gly Lys His Asp Val Gly Ala Tyr
    3810                3815                3820                
Met Leu Met Tyr Lys Gly Ala Asn Arg Thr Glu Thr Val Thr Ser Phe
3825                3830                3835                3840
Arg Lys Arg Glu Ser Lys Val Pro Ala Asp Leu Leu Lys Arg Ala Phe
                3845                3850                3855    
Val Arg Met Ser Thr Ser Pro Glu Ala Phe Leu Ala Leu Arg Ser His
            3860                3865                3870        
Phe Ala Ser Ser His Ala Leu Ile Cys Ile Ser His Trp Ile Leu Gly
        3875                3880                3885            
Ile Gly Asp Arg His Leu Asn Asn Phe Met Val Ala Met Glu Thr Gly
    3890                3895                3900                
Gly Val Ile Gly Ile Asp Phe Gly His Ala Phe Gly Ser Ala Thr Gln
3905                3910                3915                3920
Phe Leu Pro Val Pro Glu Leu Met Pro Phe Arg Leu Thr Arg Gln Phe
                3925                3930                3935    
Ile Asn Leu Met Leu Pro Met Lys Glu Thr Gly Leu Met Tyr Ser Ile
            3940                3945                3950        
Met Val His Ala Leu Arg Ala Phe Arg Ser Asp Pro Gly Leu Leu Thr
        3955                3960                3965            
Asn Thr Met Asp Val Phe Val Lys Glu Pro Ser Phe Asp Trp Lys Asn
    3970                3975                3980                
Phe Glu Gln Lys Met Leu Lys Lys Gly Gly Ser Trp Ile Gln Glu Ile
3985                3990                3995                4000
Asn Val Ala Glu Lys Asn Trp Tyr Pro Arg Gln Lys Ile Cys Tyr Ala
                4005                4010                4015    
Lys Arg Lys Leu Ala Gly Ala Asn Pro Ala Val Ile Thr Cys Asp Glu
            4020                4025                4030        
Leu Leu Leu Gly His Glu Lys Ala Pro Ala Phe Arg Asp Tyr Val Ala
        4035                4040                4045            
Val Ala Arg Gly Ser Lys Asp His Asn Ile Arg Ala Gln Glu Pro Glu
    4050                4055                4060                
Ser Gly Leu Ser Glu Glu Thr Gln Val Lys Cys Leu Met Asp Gln Ala
4065                4070                4075                4080
Thr Asp Pro Asn Ile Leu Gly Arg Thr Trp Glu Gly Trp Glu Pro Trp
                4085                4090                4095    
Met
    


<210> 1599
<211> 166
<212> PRT
<213> Homo sapiens

<400> 1599
Ala Phe Ala Ala Trp Glu Pro Ser Gly Ala Ala Val Ser Arg Ser Pro
 1               5                  10                  15      
Leu Ser Pro Pro Ser Arg Pro Phe Ala Ser Arg Glu Pro Ala Gly Phe
            20                  25                  30          
Arg Ala Ala Leu Ala Asp Pro Pro Gly Met Pro Arg Tyr Glu Leu Ala
        35                  40                  45              
Leu Ile Leu Lys Ala Met Gln Arg Pro Glu Thr Ala Ala Thr Leu Lys
    50                  55                  60                  
Arg Thr Ile Glu Ala Leu Met Asp Arg Gly Ala Ile Val Arg Asp Leu
65                  70                  75                  80  
Glu Asn Leu Gly Glu Arg Ala Leu Pro Tyr Arg Ile Ser Ala His Ser
                85                  90                  95      
Gln Gln His Asn Arg Gly Gly Tyr Phe Leu Val Asp Phe Tyr Ala Pro
            100                 105                 110         
Thr Ala Ala Val Glu Ser Met Val Glu His Leu Ser Arg Asp Ile Asp
        115                 120                 125             
Val Ile Arg Gly Asn Ile Val Lys His Pro Leu Thr Gln Glu Leu Lys
    130                 135                 140                 
Glu Cys Glu Gly Ile Val Pro Val Pro Leu Ala Glu Lys Leu Tyr Ser
145                 150                 155                 160 
Thr Lys Lys Arg Lys Lys
                165     


<210> 1600
<211> 337
<212> PRT
<213> Homo sapiens

<400> 1600
Gly Thr Arg His Phe Gln Ser Pro Pro Pro Val Pro Gly Glu Val Leu
 1               5                  10                  15      
Lys Leu Asp Asp Val Ile Asp Asn Ile Met Arg Leu Asp Asp Val Leu
            20                  25                  30          
Gly Tyr Ile Asn Pro Glu Met Gln Met Pro Asn Thr Leu Pro Leu Ser
        35                  40                  45              
Ser Ser His Leu Asn Val Tyr Ser Ser Asp Pro Gln Val Thr Ala Ser
    50                  55                  60                  
Leu Val Gly Val Thr Ser Ser Ser Cys Pro Ala Asp Leu Thr Gln Lys
65                  70                  75                  80  
Arg Glu Leu Thr Asp Ala Glu Ser Arg Ala Leu Ala Lys Glu Arg Gln
                85                  90                  95      
Lys Lys Asp Asn His Asn Leu Ile Glu Arg Arg Arg Arg Phe Asn Ile
            100                 105                 110         
Asn Asp Arg Ile Lys Glu Leu Gly Met Leu Ile Pro Lys Ala Asn Asp
        115                 120                 125             
Leu Asp Val Arg Trp Asn Lys Gly Thr Ile Leu Lys Ala Ser Val Asp
    130                 135                 140                 
Tyr Ile Arg Arg Met Gln Lys Asp Leu Gln Lys Ser Arg Glu Leu Glu
145                 150                 155                 160 
Asn His Ser Arg Arg Leu Glu Met Thr Asn Lys Gln Leu Trp Leu Arg
                165                 170                 175     
Ile Gln Glu Leu Glu Met Gln Ala Arg Val His Gly Leu Pro Thr Thr
            180                 185                 190         
Ser Pro Ser Gly Met Asn Met Ala Glu Leu Ala Gln Gln Val Val Lys
        195                 200                 205             
Gln Glu Leu Pro Ser Glu Glu Gly Pro Gly Glu Ala Leu Met Leu Gly
    210                 215                 220                 
Ala Glu Val Pro Asp Pro Glu Pro Leu Pro Ala Leu Pro Pro Gln Ala
225                 230                 235                 240 
Pro Leu Pro Leu Pro Thr Gln Pro Pro Ser Pro Phe His His Leu Asp
                245                 250                 255     
Phe Ser His Ser Leu Ser Phe Gly Gly Arg Glu Asp Glu Gly Pro Pro
            260                 265                 270         
Gly Tyr Pro Glu Pro Leu Ala Pro Gly His Gly Ser Pro Phe Pro Ser
        275                 280                 285             
Leu Ser Lys Lys Asp Leu Asp Leu Met Leu Leu Asp Asp Ser Leu Leu
    290                 295                 300                 
Pro Leu Ala Ser Asp Pro Leu Leu Ser Thr Met Ser Pro Glu Ala Ser
305                 310                 315                 320 
Lys Ala Ser Ser Arg Arg Ser Ser Phe Ser Met Glu Glu Gly Asp Val
                325                 330                 335     
Leu
    


<210> 1601
<211> 542
<212> PRT
<213> Homo sapiens

<400> 1601
His Glu Gly Arg Met Ala Ala Glu Gln Asp Pro Glu Ala Arg Ala Ala
 1               5                  10                  15      
Ala Arg Pro Leu Leu Thr Asp Leu Tyr Gln Ala Thr Met Ala Leu Gly
            20                  25                  30          
Tyr Trp Arg Ala Gly Arg Ala Arg Asp Ala Ala Glu Phe Glu Leu Phe
        35                  40                  45              
Phe Arg Arg Cys Pro Phe Gly Gly Ala Phe Ala Leu Ala Ala Gly Leu
    50                  55                  60                  
Arg Asp Cys Val Arg Phe Leu Arg Ala Phe Arg Leu Arg Asp Ala Asp
65                  70                  75                  80  
Val Gln Phe Leu Ala Ser Val Leu Pro Pro Asp Thr Asp Pro Ala Phe
                85                  90                  95      
Phe Glu His Leu Arg Ala Leu Asp Cys Ser Glu Val Thr Val Arg Ala
            100                 105                 110         
Leu Pro Glu Gly Ser Leu Ala Phe Pro Gly Val Pro Leu Leu Gln Val
        115                 120                 125             
Ser Gly Pro Leu Leu Val Val Gln Leu Leu Glu Thr Pro Leu Leu Cys
    130                 135                 140                 
Leu Val Ser Tyr Ala Ser Leu Val Ala Thr Asn Ala Ala Arg Leu Arg
145                 150                 155                 160 
Leu Ile Ala Gly Pro Glu Lys Arg Leu Leu Glu Met Gly Leu Arg Arg
                165                 170                 175     
Ala Gln Gly Pro Asp Gly Gly Leu Thr Ala Ser Thr Tyr Ser Tyr Leu
            180                 185                 190         
Gly Gly Phe Asp Ser Ser Ser Asn Val Leu Ala Gly Gln Leu Arg Gly
        195                 200                 205             
Val Pro Val Ala Gly Thr Leu Ala His Ser Phe Val Thr Ser Phe Ser
    210                 215                 220                 
Gly Ser Glu Val Pro Pro Asp Pro Met Leu Ala Pro Ala Ala Gly Glu
225                 230                 235                 240 
Gly Pro Gly Val Asp Leu Ala Ala Lys Ala Gln Val Trp Leu Glu Gln
                245                 250                 255     
Val Cys Ala His Leu Gly Leu Gly Val Gln Glu Pro His Pro Gly Glu
            260                 265                 270         
Arg Ala Ala Phe Val Ala Tyr Ala Leu Ala Phe Pro Arg Ala Phe Gln
        275                 280                 285             
Gly Leu Leu Asp Thr Tyr Ser Val Trp Arg Ser Gly Leu Pro Asn Phe
    290                 295                 300                 
Leu Ala Val Ala Leu Ala Leu Gly Glu Leu Gly Tyr Arg Ala Val Gly
305                 310                 315                 320 
Val Arg Leu Asp Ser Gly Asp Leu Leu Gln Gln Ala Gln Glu Ile Arg
                325                 330                 335     
Lys Val Phe Arg Ala Ala Ala Ala Gln Phe Gln Val Pro Trp Leu Glu
            340                 345                 350         
Ser Val Leu Ile Val Val Ser Asn Asn Ile Asp Glu Glu Ala Leu Ala
        355                 360                 365             
Arg Leu Ala Gln Glu Gly Ser Glu Val Asn Val Ile Gly Ile Gly Thr
    370                 375                 380                 
Ser Val Val Thr Cys Pro Gln Gln Pro Ser Leu Gly Gly Val Tyr Lys
385                 390                 395                 400 
Leu Val Ala Val Gly Gly Gln Pro Arg Met Lys Leu Thr Glu Asp Pro
                405                 410                 415     
Glu Lys Gln Thr Leu Pro Gly Ser Lys Ala Ala Phe Arg Leu Leu Gly
            420                 425                 430         
Ser Asp Gly Ser Pro Leu Met Asp Met Leu Gln Leu Ala Glu Glu Pro
        435                 440                 445             
Val Pro Gln Ala Gly Gln Glu Leu Arg Val Trp Pro Pro Gly Ala Gln
    450                 455                 460                 
Glu Pro Cys Thr Val Arg Pro Ala Gln Val Glu Pro Leu Leu Arg Leu
465                 470                 475                 480 
Cys Leu Gln Gln Gly Gln Leu Cys Glu Pro Leu Pro Ser Leu Ala Glu
                485                 490                 495     
Ser Arg Ala Leu Ala Gln Leu Ser Leu Ser Arg Leu Ser Pro Glu His
            500                 505                 510         
Arg Arg Leu Arg Ser Pro Ala Gln Tyr Gln Val Val Leu Ser Glu Arg
        515                 520                 525             
Leu Gln Ala Leu Val Asn Ser Leu Cys Ala Gly Gln Ser Pro
    530                 535                 540         


<210> 1602
<211> 483
<212> PRT
<213> Homo sapiens

<400> 1602
Met Ser Asn Lys Leu Leu Ser Pro His Pro His Ser Val Val Leu Arg
 1               5                  10                  15      
Ser Glu Phe Lys Met Ala Ser Ser Pro Ala Val Leu Arg Ala Ser Arg
            20                  25                  30          
Leu Tyr Gln Trp Ser Leu Lys Ser Ser Ala Gln Phe Leu Gly Ser Pro
        35                  40                  45              
Gln Leu Arg Gln Val Gly Gln Ile Ile Arg Val Pro Ala Arg Met Ala
    50                  55                  60                  
Ala Thr Leu Ile Leu Glu Pro Ala Gly Arg Cys Cys Trp Asp Glu Pro
65                  70                  75                  80  
Val Arg Ile Ala Val Arg Gly Leu Ala Pro Glu Gln Pro Val Thr Leu
                85                  90                  95      
Arg Ala Ser Leu Arg Asp Glu Lys Gly Ala Leu Phe Gln Ala His Ala
            100                 105                 110         
Arg Tyr Arg Ala Asp Thr Leu Gly Glu Leu Asp Leu Glu Arg Ala Pro
        115                 120                 125             
Ala Leu Gly Gly Ser Phe Ala Gly Leu Glu Pro Met Gly Leu Leu Trp
    130                 135                 140                 
Ala Leu Glu Pro Glu Lys Pro Leu Val Arg Leu Val Lys Arg Asp Val
145                 150                 155                 160 
Arg Thr Pro Leu Ala Val Glu Leu Glu Val Leu Asp Gly His Asp Pro
                165                 170                 175     
Asp Pro Gly Arg Leu Leu Cys Gln Thr Arg His Glu Arg Tyr Phe Leu
            180                 185                 190         
Pro Pro Gly Val Arg Arg Glu Pro Val Arg Val Gly Arg Val Arg Gly
        195                 200                 205             
Thr Leu Phe Leu Pro Pro Glu Pro Gly Pro Phe Pro Gly Ile Val Asp
    210                 215                 220                 
Met Phe Gly Thr Gly Gly Gly Leu Leu Glu Tyr Arg Ala Ser Leu Leu
225                 230                 235                 240 
Ala Gly Lys Gly Phe Ala Val Met Ala Leu Ala Tyr Tyr Asn Tyr Glu
                245                 250                 255     
Asp Leu Pro Lys Thr Met Glu Thr Leu His Leu Glu Tyr Phe Glu Glu
            260                 265                 270         
Ala Met Asn Tyr Leu Leu Ser His Pro Glu Val Lys Gly Pro Gly Val
        275                 280                 285             
Gly Leu Leu Gly Ile Ser Lys Gly Gly Glu Leu Cys Leu Ser Met Ala
    290                 295                 300                 
Ser Phe Leu Lys Gly Ile Thr Ala Ala Val Val Ile Asn Gly Ser Val
305                 310                 315                 320 
Ala Asn Val Gly Gly Thr Leu Arg Tyr Lys Gly Glu Thr Leu Pro Pro
                325                 330                 335     
Val Gly Val Asn Arg Asn Arg Ile Lys Val Thr Lys Asp Gly Tyr Ala
            340                 345                 350         
Asp Ile Val Asp Val Leu Asn Ser Pro Leu Glu Gly Pro Asp Gln Lys
        355                 360                 365             
Ser Phe Ile Pro Val Glu Arg Ala Glu Ser Thr Phe Leu Phe Leu Val
    370                 375                 380                 
Gly Gln Asp Asp His Asn Trp Lys Ser Glu Phe Tyr Ala Asn Glu Ala
385                 390                 395                 400 
Cys Lys Arg Leu Gln Ala His Gly Arg Arg Lys Pro Gln Ile Ile Cys
                405                 410                 415     
Tyr Pro Glu Thr Gly His Tyr Ile Glu Pro Pro Tyr Phe Pro Leu Cys
            420                 425                 430         
Arg Ala Ser Leu His Ala Leu Val Gly Ser Pro Ile Ile Trp Gly Gly
        435                 440                 445             
Glu Pro Arg Ala His Val Met Ala Gln Val Asp Ala Trp Lys Gln Leu
    450                 455                 460                 
Gln Thr Phe Phe His Lys His Leu Gly Gly His Glu Gly Thr Ile Pro
465                 470                 475                 480 
Ser Lys Val
            


<210> 1603
<211> 311
<212> PRT
<213> Homo sapiens

<400> 1603
His Glu Ala Arg Tyr Ser Val Gln Leu Met Ser Phe Val Tyr Asn Leu
 1               5                  10                  15      
Ser Asp Thr His Leu Phe Pro Asn Ala Ser Ser Lys Glu Ile Lys Thr
            20                  25                  30          
Val Glu Ser Ile Thr Asp Ile Arg Ala Asp Ile Asp Lys Lys Tyr Arg
        35                  40                  45              
Cys Val Ser Gly Thr Gln Val His Met Asn Asn Val Thr Val Thr Leu
    50                  55                  60                  
His Asp Ala Thr Ile Gln Ala Tyr Leu Ser Asn Ser Ser Phe Ser Arg
65                  70                  75                  80  
Gly Glu Thr Arg Cys Glu Gln Asp Arg Pro Ser Pro Thr Thr Ala Pro
                85                  90                  95      
Pro Ala Pro Pro Ser Pro Ser Pro Ser Pro Val Pro Lys Ser Pro Ser
            100                 105                 110         
Val Asp Lys Tyr Asn Val Ser Gly Thr Asn Gly Thr Cys Leu Leu Ala
        115                 120                 125             
Ser Met Gly Leu Gln Leu Asn Leu Thr Tyr Glu Arg Lys Asp Asn Thr
    130                 135                 140                 
Thr Val Thr Arg Leu Leu Asn Ile Asn Pro Asn Lys Thr Ser Ala Ser
145                 150                 155                 160 
Gly Ser Cys Gly Ala His Leu Val Thr Leu Glu Leu His Ser Glu Gly
                165                 170                 175     
Thr Thr Val Leu Leu Phe Gln Phe Gly Met Asn Ala Ser Ser Ser Arg
            180                 185                 190         
Phe Phe Leu Gln Gly Ile Gln Leu Asn Thr Ile Leu Pro Asp Ala Arg
        195                 200                 205             
Asp Pro Ala Phe Lys Ala Ala Asn Gly Ser Leu Arg Ala Leu Gln Ala
    210                 215                 220                 
Thr Val Gly Asn Ser Tyr Lys Cys Asn Ala Glu Glu His Val Arg Val
225                 230                 235                 240 
Thr Lys Ala Phe Ser Val Asn Ile Phe Lys Val Trp Val Gln Ala Phe
                245                 250                 255     
Lys Val Glu Gly Gly Gln Phe Gly Ser Val Glu Glu Cys Leu Leu Asp
            260                 265                 270         
Glu Asn Ser Met Leu Ile Pro Ile Ala Val Gly Gly Ala Leu Ala Gly
        275                 280                 285             
Leu Val Leu Ile Val Leu Ile Ala Tyr Leu Val Gly Arg Lys Arg Ser
    290                 295                 300                 
His Ala Gly Tyr Gln Thr Ile
305                 310     


<210> 1604
<211> 361
<212> PRT
<213> Homo sapiens

<400> 1604
Met Gly Asn Val Leu Ala Ala Ser Ser Pro Pro Ala Gly Pro Pro Pro
 1               5                  10                  15      
Pro Pro Ala Pro Ala Leu Val Gly Leu Pro Pro Pro Pro Pro Ser Pro
            20                  25                  30          
Pro Gly Phe Thr Leu Pro Pro Leu Gly Gly Ser Leu Gly Ala Gly Thr
        35                  40                  45              
Arg Thr Ser Arg Ser Ser Glu Arg Thr Pro Gly Ala Ala Thr Ala Ser
    50                  55                  60                  
Ala Ser Gly Ala Ala Glu Asp Gly Ala Cys Gly Cys Leu Pro Asn Pro
65                  70                  75                  80  
Gly Thr Phe Glu Glu Cys His Arg Lys Cys Lys Glu Leu Phe Pro Ile
                85                  90                  95      
Gln Met Glu Gly Val Lys Leu Thr Val Asn Lys Gly Leu Ser Asn His
            100                 105                 110         
Phe Gln Val Asn His Thr Val Ala Leu Ser Thr Ile Gly Glu Ser Asn
        115                 120                 125             
Tyr His Phe Gly Val Thr Tyr Val Gly Thr Lys Gln Leu Ser Pro Thr
    130                 135                 140                 
Glu Ala Phe Pro Val Leu Val Gly Asp Met Asp Asn Ser Gly Ser Leu
145                 150                 155                 160 
Asn Ala Gln Val Ile His Gln Leu Gly Pro Gly Leu Arg Ser Lys Met
                165                 170                 175     
Ala Ile Gln Thr Gln Gln Ser Lys Phe Val Asn Trp Gln Val Asp Gly
            180                 185                 190         
Glu Tyr Arg Gly Ser Asp Phe Thr Ala Ala Val Thr Leu Gly Asn Pro
        195                 200                 205             
Asp Val Leu Val Gly Ser Gly Ile Leu Val Ala His Tyr Leu Gln Ser
    210                 215                 220                 
Ile Thr Pro Cys Leu Ala Leu Gly Gly Glu Leu Val Tyr His Arg Arg
225                 230                 235                 240 
Pro Gly Glu Glu Gly Thr Val Met Ser Leu Ala Gly Lys Tyr Thr Leu
                245                 250                 255     
Asn Asn Trp Leu Ala Thr Val Thr Leu Gly Gln Ala Gly Met His Ala
            260                 265                 270         
Thr Tyr Tyr His Lys Ala Ser Asp Gln Leu Gln Val Gly Val Glu Phe
        275                 280                 285             
Glu Ala Ser Thr Arg Met Gln Asp Thr Ser Val Ser Phe Gly Tyr Gln
    290                 295                 300                 
Leu Asp Leu Pro Lys Ala Asn Leu Leu Phe Lys Gly Ser Val Asp Ser
305                 310                 315                 320 
Asn Trp Ile Val Gly Ala Thr Leu Glu Lys Lys Leu Pro Pro Leu Pro
                325                 330                 335     
Leu Thr Leu Ala Leu Gly Ala Phe Leu Asn His Arg Lys Asn Lys Phe
            340                 345                 350         
Gln Cys Gly Phe Gly Leu Thr Ile Gly
        355                 360     


<210> 1605
<211> 396
<212> PRT
<213> Homo sapiens

<400> 1605
Arg Trp Thr Arg Arg Leu Arg Ala Ser Leu Ala Gly Gln Val Gly Gly
 1               5                  10                  15      
Thr Gly Leu Arg Ile Pro Arg Pro Arg Phe Gly Pro Ala Gly Asp Met
            20                  25                  30          
Ala Ser Ser Gly Glu Asp Ile Ser Asn Asp Asp Asp Asp Met His Pro
        35                  40                  45              
Ala Ala Ala Gly Met Ala Asp Gly Val His Leu Leu Gly Phe Ser Asp
    50                  55                  60                  
Glu Ile Leu Leu His Ile Leu Ser His Val Pro Ser Thr Asp Leu Ile
65                  70                  75                  80  
Leu Asn Val Arg Arg Thr Cys Arg Lys Leu Ala Ala Leu Cys Leu Asp
                85                  90                  95      
Lys Ser Leu Ile His Thr Val Leu Leu Gln Lys Asp Tyr Gln Ala Ser
            100                 105                 110         
Glu Asp Lys Val Arg Gln Leu Val Lys Glu Ile Gly Arg Glu Ile Gln
        115                 120                 125             
Gln Leu Ser Met Ala Gly Cys Tyr Trp Leu Pro Gly Ser Thr Val Glu
    130                 135                 140                 
His Val Ala Arg Cys Arg Ser Leu Val Lys Val Asn Leu Ser Gly Cys
145                 150                 155                 160 
His Leu Thr Ser Leu Arg Leu Ser Lys Met Leu Ser Ala Leu Gln His
                165                 170                 175     
Leu Arg Ser Leu Ala Ile Asp Val Ser Pro Gly Phe Asp Ala Ser Gln
            180                 185                 190         
Leu Ser Ser Glu Cys Lys Ala Thr Leu Ser Arg Val Arg Glu Leu Lys
        195                 200                 205             
Gln Thr Leu Phe Thr Pro Ser Tyr Gly Val Val Pro Cys Cys Thr Ser
    210                 215                 220                 
Leu Glu Lys Leu Leu Leu Tyr Phe Glu Ile Leu Asp Arg Thr Arg Glu
225                 230                 235                 240 
Gly Ala Ile Leu Ser Gly Gln Leu Met Val Gly Gln Ser Asn Val Pro
                245                 250                 255     
His Tyr Gln Asn Leu Arg Val Phe Tyr Ala Arg Leu Ala Pro Gly Tyr
            260                 265                 270         
Ile Asn Gln Glu Val Val Arg Leu Tyr Leu Ala Val Leu Ser Asp Arg
        275                 280                 285             
Thr Pro Gln Asn Leu His Ala Phe Leu Ile Ser Val Pro Gly Ser Phe
    290                 295                 300                 
Ala Glu Ser Gly Ala Thr Lys Asn Leu Leu Asp Ser Met Ala Arg Asn
305                 310                 315                 320 
Val Val Leu Asp Ala Leu Gln Leu Pro Lys Ser Trp Leu Asn Gly Ser
                325                 330                 335     
Ser Leu Leu Gln His Met Lys Phe Asn Asn Pro Phe Tyr Phe Ser Phe
            340                 345                 350         
Ser Arg Cys Thr Leu Ser Gly Gly His Leu Ile Gln Gln Val Ile Asn
        355                 360                 365             
Gly Gly Lys Asp Leu Arg Ser Leu Ala Ser Leu Asn Leu Ser Gly Cys
    370                 375                 380                 
Val His Cys Leu Ser Pro Asp Ser Leu Leu Cys Arg
385                 390                 395     


<210> 1606
<211> 575
<212> PRT
<213> Homo sapiens

<400> 1606
Asn Ile Glu Glu Ser Gln Ala Val Glu Ala Ala Met Ala Asn Val Pro
 1               5                  10                  15      
Trp Ala Glu Val Cys Glu Lys Phe Gln Ala Ala Leu Ala Leu Ser Arg
            20                  25                  30          
Val Glu Leu His Lys Asn Pro Glu Lys Glu Pro Tyr Lys Ser Lys Tyr
        35                  40                  45              
Ser Ala Arg Ala Leu Leu Glu Glu Val Lys Ala Leu Leu Gly Pro Ala
    50                  55                  60                  
Pro Glu Asp Glu Asp Glu Arg Pro Glu Ala Glu Asp Gly Pro Gly Ala
65                  70                  75                  80  
Gly Asp His Ala Leu Gly Leu Pro Ala Glu Val Val Glu Pro Glu Gly
                85                  90                  95      
Pro Val Ala Gln Arg Ala Val Arg Leu Ala Val Ile Glu Phe His Leu
            100                 105                 110         
Gly Val Asn His Ile Asp Thr Glu Glu Leu Ser Ala Gly Glu Glu His
        115                 120                 125             
Leu Val Lys Cys Leu Arg Leu Leu Arg Arg Tyr Arg Leu Ser His Asp
    130                 135                 140                 
Cys Ile Ser Leu Cys Ile Gln Ala Gln Asn Asn Leu Gly Ile Leu Trp
145                 150                 155                 160 
Ser Glu Arg Glu Glu Ile Glu Thr Ala Gln Ala Tyr Leu Glu Ser Ser
                165                 170                 175     
Glu Ala Leu Tyr Asn Gln Tyr Met Lys Glu Val Gly Ser Pro Pro Leu
            180                 185                 190         
Asp Pro Thr Glu Arg Phe Leu Pro Glu Glu Glu Lys Leu Thr Glu Gln
        195                 200                 205             
Glu Arg Ser Lys Arg Phe Glu Lys Val Tyr Thr His Asn Leu Tyr Tyr
    210                 215                 220                 
Leu Ala Gln Val Tyr Gln His Leu Glu Met Phe Glu Lys Ala Ala His
225                 230                 235                 240 
Tyr Cys His Ser Thr Leu Lys Arg Gln Leu Glu His Asn Ala Tyr His
                245                 250                 255     
Pro Ile Glu Trp Ala Ile Asn Ala Ala Thr Leu Ser Gln Phe Tyr Ile
            260                 265                 270         
Asn Lys Leu Cys Phe Met Glu Ala Arg His Cys Leu Ser Ala Ala Asn
        275                 280                 285             
Val Ile Phe Gly Gln Thr Gly Lys Ile Ser Ala Thr Glu Asp Thr Pro
    290                 295                 300                 
Glu Ala Glu Gly Glu Val Pro Glu Leu Tyr His Gln Arg Lys Gly Glu
305                 310                 315                 320 
Ile Ala Arg Cys Trp Ile Lys Tyr Cys Leu Thr Leu Met Gln Asn Ala
                325                 330                 335     
Gln Leu Ser Met Gln Asp Asn Ile Gly Glu Leu Asp Leu Asp Lys Gln
            340                 345                 350         
Ser Glu Leu Arg Ala Leu Arg Lys Lys Glu Leu Asp Glu Glu Glu Ser
        355                 360                 365             
Ile Arg Lys Lys Ala Val Gln Phe Gly Thr Gly Glu Leu Cys Asp Ala
    370                 375                 380                 
Ile Ser Ala Val Glu Glu Lys Val Ser Tyr Leu Arg Pro Leu Asp Phe
385                 390                 395                 400 
Glu Glu Ala Arg Glu Leu Phe Leu Leu Gly Gln His Tyr Val Phe Glu
                405                 410                 415     
Ala Lys Glu Phe Phe Gln Ile Asp Gly Tyr Val Thr Asp His Ile Glu
            420                 425                 430         
Val Val Gln Asp His Ser Ala Leu Phe Lys Val Leu Ala Phe Phe Glu
        435                 440                 445             
Thr Asp Met Glu Arg Arg Cys Lys Met His Lys Arg Arg Ile Ala Met
    450                 455                 460                 
Leu Glu Pro Leu Thr Val Asp Leu Asn Pro Gln Tyr Tyr Leu Leu Val
465                 470                 475                 480 
Asn Arg Gln Ile Gln Phe Glu Ile Ala His Ala Tyr Tyr Asp Met Met
                485                 490                 495     
Asp Leu Lys Val Ala Ile Ala Asp Arg Leu Arg Asp Pro Asp Ser His
            500                 505                 510         
Ile Val Lys Lys Ile Asn Asn Leu Asn Lys Ser Ala Leu Lys Tyr Tyr
        515                 520                 525             
Gln Leu Phe Leu Asp Ser Leu Arg Asp Pro Asn Lys Val Phe Pro Glu
    530                 535                 540                 
His Ile Gly Glu Asp Val Leu Arg Pro Ala Met Leu Ala Lys Phe Arg
545                 550                 555                 560 
Val Ala Arg Leu Tyr Gly Lys Ile Ile Thr Ala Asp Pro Lys Lys
                565                 570                 575 


<210> 1607
<211> 1016
<212> PRT
<213> Homo sapiens

<400> 1607
Ala Gly Gly Ser Glu Arg Glu Leu Gly Leu Ala Asp Gly Met Glu Asp
 1               5                  10                  15      
Tyr Glu Gln Glu Leu Cys Gly Val Glu Asp Asp Phe His Asn Gln Phe
            20                  25                  30          
Ala Ala Glu Leu Glu Val Leu Ala Glu Leu Glu Gly Ala Ser Thr Pro
        35                  40                  45              
Ser Pro Ser Gly Val Pro Leu Phe Thr Ala Gly Arg Pro Pro Arg Thr
    50                  55                  60                  
Phe Glu Glu Ala Leu Ala Arg Gly Asp Ala Ala Ser Ser Pro Ala Pro
65                  70                  75                  80  
Ala Ala Ser Val Gly Ser Ser Gln Gly Gly Ala Arg Lys Arg Gln Val
                85                  90                  95      
Asp Ala Asp Leu Gln Pro Ala Gly Ser Leu Pro His Gly Arg Leu Ala
            100                 105                 110         
Ala Leu Pro Gln Gly Leu Arg Ser Gly Arg Glu Ala Glu Glu Ala Ser
        115                 120                 125             
Gly Ser Leu His Val Ser Pro Pro Ala Pro Arg Ile Lys Arg Pro Arg
    130                 135                 140                 
Leu Gln Val Val Lys Arg Leu Asn Phe Arg Ser Glu Glu Met Glu Glu
145                 150                 155                 160 
Pro Pro Pro Pro Asp Ser Ser Pro Thr Asp Ile Thr Pro Pro Pro Ser
                165                 170                 175     
Pro Glu Asp Leu Ala Glu Leu Trp Gly His Gly Val Ser Glu Ala Ala
            180                 185                 190         
Ala Asp Val Gly Leu Thr Arg Ala Ser Pro Ala Ala Arg Asn Pro Val
        195                 200                 205             
Leu Arg Arg Pro Pro Ile Leu Glu Asp Tyr Val His Val Thr Ser Thr
    210                 215                 220                 
Glu Gly Val Arg Ala Tyr Leu Val Leu Arg Ala Asp Pro Met Ala Pro
225                 230                 235                 240 
Gly Val Gln Gly Ser Leu Leu His Val Pro Trp Arg Gly Gly Gly Gln
                245                 250                 255     
Leu Asp Leu Leu Gly Val Ser Leu Ala Ser Leu Lys Lys Gln Val Asp
            260                 265                 270         
Gly Glu Arg Arg Glu Arg Leu Leu Gln Glu Ala Gln Lys Leu Ser Asp
        275                 280                 285             
Thr Leu His Ser Leu Arg Ser Gly Glu Glu Glu Ala Ala Gln Pro Leu
    290                 295                 300                 
Gly Ala Pro Glu Glu Glu Pro Thr Asp Gly Gln Asp Ala Ser Ser His
305                 310                 315                 320 
Cys Leu Trp Val Asp Glu Phe Ala Pro Arg His Tyr Thr Glu Leu Leu
                325                 330                 335     
Ser Asp Asp Phe Thr Asn Arg Cys Leu Leu Lys Trp Leu Lys Leu Trp
            340                 345                 350         
Asp Leu Val Val Phe Gly His Glu Arg Pro Ser Arg Lys Pro Arg Pro
        355                 360                 365             
Ser Val Glu Pro Ala Arg Val Ser Lys Glu Ala Thr Ala Pro Gly Lys
    370                 375                 380                 
Trp Lys Ser His Glu Gln Val Leu Glu Glu Met Leu Glu Ala Gly Leu
385                 390                 395                 400 
Asp Pro Ser Gln Arg Pro Lys Gln Lys Val Ala Leu Leu Cys Gly Pro
                405                 410                 415     
Pro Gly Leu Gly Lys Thr Thr Leu Ala His Val Ile Ala Arg His Ala
            420                 425                 430         
Gly Tyr Ser Val Val Glu Met Asn Ala Ser Asp Asp Arg Ser Pro Glu
        435                 440                 445             
Val Phe Arg Thr Arg Ile Glu Ala Ala Thr Gln Met Glu Ser Val Leu
    450                 455                 460                 
Gly Ala Gly Gly Lys Pro Asn Cys Leu Val Ile Asp Glu Ile Asp Gly
465                 470                 475                 480 
Ala Pro Val Ala Ala Ile Asn Val Leu Leu Ser Ile Leu Asn Arg Lys
                485                 490                 495     
Gly Pro Gln Glu Val Gly Pro Gln Gly Pro Ala Val Pro Ser Gly Gly
            500                 505                 510         
Gly Arg Arg Arg Arg Ala Glu Gly Gly Leu Leu Met Arg Pro Ile Ile
        515                 520                 525             
Cys Ile Cys Asn Asp Gln Phe Ala Pro Ser Leu Arg Gln Leu Lys Gln
    530                 535                 540                 
Gln Ala Phe Leu Leu His Phe Pro Pro Thr Leu Pro Ser Arg Leu Val
545                 550                 555                 560 
Gln Arg Leu Gln Glu Val Ser Leu Arg Gln Gly Met Arg Ala Asp Pro
                565                 570                 575     
Gly Val Leu Ala Ala Leu Cys Glu Lys Thr Asp Asn Asp Ile Arg Ala
            580                 585                 590         
Cys Ile Asn Thr Leu Gln Phe Leu Tyr Ser Arg Gly Gln Arg Glu Leu
        595                 600                 605             
Ser Val Arg Asp Val Gln Ala Thr Arg Val Gly Leu Lys Asp Gln Arg
    610                 615                 620                 
Arg Gly Leu Phe Ser Val Trp Gln Glu Val Phe Gln Leu Pro Arg Ala
625                 630                 635                 640 
Gln Arg Arg Arg Val Gly Gln Asp Pro Ala Leu Pro Ala Asp Thr Leu
                645                 650                 655     
Leu Leu Gly Asp Gly Asp Ala Gly Ser Leu Thr Ser Ala Ser Gln Arg
            660                 665                 670         
Phe Tyr Arg Val Leu His Ala Ala Ala Ser Ala Gly Glu His Glu Lys
        675                 680                 685             
Val Val Gln Gly Leu Phe Asp Asn Phe Leu Arg Leu Arg Leu Arg Asp
    690                 695                 700                 
Ser Ser Leu Gly Ala Val Cys Val Ala Leu Asp Trp Leu Ala Phe Asp
705                 710                 715                 720 
Asp Leu Leu Ala Gly Ala Ala His His Ser Gln Ser Phe Gln Leu Leu
                725                 730                 735     
Arg Tyr Pro Pro Phe Leu Pro Val Ala Phe His Val Leu Phe Ala Ser
            740                 745                 750         
Ser His Thr Pro Arg Ile Thr Phe Pro Ser Ser Gln Gln Glu Ala Gln
        755                 760                 765             
Asn Arg Met Ser Gln Met Arg Asn Leu Ile Gln Thr Leu Val Ser Gly
    770                 775                 780                 
Ile Ala Pro Ala Thr Arg Ser Arg Ala Thr Pro Gln Ala Leu Leu Leu
785                 790                 795                 800 
Asp Ala Leu Cys Leu Leu Leu Asp Ile Leu Ala Pro Lys Leu Arg Pro
                805                 810                 815     
Val Ser Thr Gln Leu Tyr Ser Thr Arg Glu Lys Gln Gln Leu Ala Ser
            820                 825                 830         
Leu Val Gly Thr Met Leu Ala Tyr Ser Leu Thr Tyr Arg Gln Glu Arg
        835                 840                 845             
Thr Pro Asp Gly Gln Tyr Ile Tyr Arg Leu Glu Pro Asn Val Glu Glu
    850                 855                 860                 
Leu Cys Arg Phe Pro Glu Leu Pro Ala Arg Lys Pro Leu Thr Tyr Gln
865                 870                 875                 880 
Thr Lys Gln Leu Ile Ala Arg Glu Ile Glu Val Glu Lys Met Arg Arg
                885                 890                 895     
Ala Glu Ala Ser Ala Arg Val Glu Asn Ser Pro Gln Val Asp Gly Ser
            900                 905                 910         
Pro Pro Gly Leu Glu Gly Leu Leu Gly Gly Ile Gly Glu Lys Gly Val
        915                 920                 925             
His Arg Pro Ala Pro Arg Asn His Glu Gln Arg Leu Glu His Ile Met
    930                 935                 940                 
Arg Arg Ala Ala Arg Glu Glu Gln Pro Glu Lys Asp Phe Phe Gly Arg
945                 950                 955                 960 
Val Val Val Arg Ser Thr Ala Val Pro Ser Ala Gly Asp Thr Ala Pro
                965                 970                 975     
Glu Gln Asp Ser Val Glu Arg Arg Met Gly Thr Ala Val Gly Arg Ser
            980                 985                 990         
Glu Val Trp Phe Arg Phe Asn Glu Gly Val Ser Asn Ala Val Arg Arg
        995                 1000                1005            
Ser Leu Tyr Ile Arg Asp Leu Leu
    1010                1015    


<210> 1608
<211> 231
<212> PRT
<213> Homo sapiens

<400> 1608
Met Phe Leu Val Gly Leu Thr Gly Gly Ile Ala Ser Gly Lys Ser Ser
 1               5                  10                  15      
Val Ile Gln Val Phe Gln Gln Leu Gly Cys Ala Val Ile Asp Val Asp
            20                  25                  30          
Val Met Ala Arg His Val Val Gln Pro Gly Tyr Pro Ala His Arg Arg
        35                  40                  45              
Ile Val Glu Val Phe Gly Thr Glu Val Leu Leu Glu Asn Gly Asp Ile
    50                  55                  60                  
Asn Arg Lys Val Leu Gly Asp Leu Ile Phe Asn Gln Pro Asp Arg Arg
65                  70                  75                  80  
Gln Leu Leu Ile Ala Ile Thr His Pro Glu Ile Arg Lys Glu Met Met
                85                  90                  95      
Lys Glu Thr Phe Lys Tyr Phe Leu Arg Gly Tyr Arg Tyr Val Ile Leu
            100                 105                 110         
Asp Ile Pro Leu Leu Phe Glu Thr Lys Lys Leu Leu Lys Tyr Met Lys
        115                 120                 125             
His Thr Val Val Val Tyr Cys Asp Arg Asp Thr Gln Leu Ala Arg Leu
    130                 135                 140                 
Met Arg Arg Asn Ser Leu Asn Arg Lys Asp Ala Glu Ala Arg Ile Asn
145                 150                 155                 160 
Ala Gln Leu Pro Leu Thr Asp Lys Ala Arg Met Ala Arg His Val Leu
                165                 170                 175     
Asp Asn Ser Gly Glu Trp Ser Val Thr Lys Arg Gln Val Ile Leu Leu
            180                 185                 190         
His Thr Glu Leu Glu Arg Ser Leu Glu Tyr Leu Pro Leu Arg Phe Gly
        195                 200                 205             
Val Leu Thr Gly Leu Ala Ala Ile Ala Ser Leu Leu Tyr Leu Leu Thr
    210                 215                 220                 
His Tyr Leu Leu Pro Tyr Ala
225                 230     


<210> 1609
<211> 1027
<212> PRT
<213> Homo sapiens

<400> 1609
Ala Asp Lys Thr Pro Gly Gly Ser Gln Lys Ala Ser Ser Lys Thr Arg
 1               5                  10                  15      
Ser Ser Asp Val His Ser Ser Gly Ser Ser Asp Ala His Met Asp Ala
            20                  25                  30          
Ser Gly Pro Ser Asp Ser Asp Met Pro Ser Arg Thr Arg Pro Lys Ser
        35                  40                  45              
Pro Arg Lys His Asn Tyr Arg Asn Glu Ser Ala Arg Glu Ser Leu Cys
    50                  55                  60                  
Asp Ser Pro His Gln Asn Leu Ser Arg Pro Leu Leu Glu Asn Lys Leu
65                  70                  75                  80  
Lys Ala Phe Ser Ile Gly Lys Met Ser Thr Ala Lys Arg Thr Leu Ser
                85                  90                  95      
Lys Lys Glu Gln Glu Glu Leu Lys Lys Lys Glu Asp Glu Lys Ala Ala
            100                 105                 110         
Ala Glu Ile Tyr Glu Glu Phe Leu Ala Ala Phe Glu Gly Ser Asp Gly
        115                 120                 125             
Asn Lys Val Lys Thr Phe Val Arg Gly Gly Val Val Asn Ala Ala Lys
    130                 135                 140                 
Glu Glu His Glu Thr Asp Glu Lys Arg Gly Lys Ile Tyr Lys Pro Ser
145                 150                 155                 160 
Ser Arg Phe Ala Asp Gln Lys Asn Pro Pro Asn Gln Ser Ser Asn Glu
                165                 170                 175     
Arg Pro Pro Ser Leu Leu Val Ile Glu Thr Lys Lys Pro Pro Leu Lys
            180                 185                 190         
Lys Gly Glu Lys Glu Lys Lys Lys Ser Asn Leu Glu Leu Phe Lys Glu
        195                 200                 205             
Glu Leu Lys Gln Ile Gln Glu Glu Arg Asp Glu Arg His Lys Thr Lys
    210                 215                 220                 
Gly Arg Leu Ser Arg Phe Glu Pro Pro Gln Ser Asp Ser Asp Gly Gln
225                 230                 235                 240 
Arg Arg Ser Met Asp Ala Pro Ser Arg Arg Asn Arg Ser Ser Val Leu
                245                 250                 255     
Asp Asp Tyr Ala Pro Gly Ser His Asp Val Gly Asp Pro Ser Thr Thr
            260                 265                 270         
Asn Leu Tyr Leu Gly Asn Ile Asn Pro Gln Met Asn Glu Glu Met Leu
        275                 280                 285             
Cys Gln Glu Phe Gly Arg Phe Gly Pro Leu Ala Ser Val Lys Ile Met
    290                 295                 300                 
Trp Pro Arg Thr Asp Glu Glu Arg Ala Arg Glu Arg Asn Cys Gly Phe
305                 310                 315                 320 
Val Ala Phe Met Asn Arg Arg Asp Ala Glu Arg Ala Leu Lys Asn Leu
                325                 330                 335     
Asn Gly Lys Met Ile Met Ser Phe Glu Met Lys Leu Gly Trp Gly Lys
            340                 345                 350         
Ala Val Pro Ile Pro Pro His Pro Ile Tyr Ile Pro Pro Ser Met Met
        355                 360                 365             
Glu His Thr Leu Pro Pro Pro Pro Ser Gly Leu Pro Phe Asn Ala Gln
    370                 375                 380                 
Pro Arg Glu Arg Leu Lys Asn Pro Asn Ala Pro Met Leu Pro Pro Pro
385                 390                 395                 400 
Lys Asn Lys Glu Asp Phe Glu Lys Thr Leu Ser Gln Ala Ile Val Lys
                405                 410                 415     
Val Val Ile Pro Thr Glu Arg Asn Leu Leu Ala Leu Ile His Arg Met
            420                 425                 430         
Ile Glu Phe Val Val Arg Glu Gly Pro Met Phe Glu Ala Met Ile Met
        435                 440                 445             
Asn Arg Glu Ile Asn Asn Pro Met Phe Arg Phe Leu Phe Glu Asn Gln
    450                 455                 460                 
Thr Pro Ala His Val Tyr Tyr Arg Trp Lys Leu Tyr Ser Ile Leu Gln
465                 470                 475                 480 
Gly Asp Ser Pro Thr Lys Trp Arg Thr Glu Asp Phe Arg Met Phe Lys
                485                 490                 495     
Asn Gly Ser Phe Trp Arg Pro Pro Pro Leu Asn Pro Tyr Leu His Gly
            500                 505                 510         
Met Ser Glu Glu Gln Glu Thr Glu Ala Phe Val Glu Glu Pro Ser Lys
        515                 520                 525             
Lys Gly Ala Leu Lys Glu Glu Gln Arg Asp Lys Leu Glu Glu Ile Leu
    530                 535                 540                 
Arg Gly Leu Thr Pro Arg Lys Asn Asp Ile Gly Asp Ala Met Val Phe
545                 550                 555                 560 
Cys Leu Asn Asn Ala Glu Ala Ala Glu Glu Ile Val Asp Cys Ile Thr
                565                 570                 575     
Glu Ser Leu Ser Ile Leu Lys Thr Pro Leu Pro Lys Lys Ile Ala Arg
            580                 585                 590         
Leu Tyr Leu Val Ser Asp Val Leu Tyr Asn Ser Ser Ala Lys Val Ala
        595                 600                 605             
Asn Ala Ser Tyr Tyr Arg Lys Phe Phe Glu Thr Lys Leu Cys Gln Ile
    610                 615                 620                 
Phe Ser Asp Leu Asn Ala Thr Tyr Arg Thr Ile Gln Gly His Leu Gln
625                 630                 635                 640 
Ser Glu Asn Phe Lys Gln Arg Val Met Thr Cys Phe Arg Ala Trp Glu
                645                 650                 655     
Asp Trp Ala Ile Tyr Pro Glu Pro Phe Leu Ile Lys Leu Gln Asn Ile
            660                 665                 670         
Phe Leu Gly Leu Val Asn Ile Ile Glu Glu Lys Glu Thr Glu Asp Val
        675                 680                 685             
Pro Asp Asp Leu Asp Gly Ala Pro Ile Glu Glu Glu Leu Asp Gly Ala
    690                 695                 700                 
Pro Leu Glu Asp Val Asp Gly Ile Pro Ile Asp Ala Thr Pro Ile Asp
705                 710                 715                 720 
Asp Leu Asp Gly Val Pro Ile Lys Ser Leu Asp Asp Asp Leu Asp Gly
                725                 730                 735     
Val Pro Leu Asp Ala Thr Glu Asp Ser Lys Lys Asn Glu Pro Ile Phe
            740                 745                 750         
Lys Val Ala Pro Ser Lys Trp Glu Ala Val Asp Glu Ser Glu Leu Glu
        755                 760                 765             
Ala Gln Ala Val Thr Thr Ser Lys Trp Glu Leu Phe Asp Gln His Glu
    770                 775                 780                 
Glu Ser Glu Glu Glu Glu Asn Gln Asn Gln Glu Glu Glu Ser Glu Asp
785                 790                 795                 800 
Glu Glu Asp Thr Gln Ser Ser Lys Ser Glu Glu His His Leu Tyr Ser
                805                 810                 815     
Asn Pro Ile Lys Glu Glu Met Thr Glu Ser Lys Phe Ser Lys Tyr Ser
            820                 825                 830         
Glu Met Ser Glu Glu Lys Arg Ala Lys Leu Arg Glu Ile Glu Leu Lys
        835                 840                 845             
Val Met Lys Phe Gln Asp Glu Leu Glu Ser Gly Lys Arg Pro Lys Lys
    850                 855                 860                 
Pro Gly Gln Ser Phe Gln Glu Gln Val Glu His Tyr Arg Asp Lys Leu
865                 870                 875                 880 
Leu Gln Arg Glu Lys Glu Lys Glu Leu Glu Arg Glu Arg Glu Arg Asp
                885                 890                 895     
Lys Lys Asp Lys Glu Lys Leu Glu Ser Arg Ser Lys Asp Lys Lys Glu
            900                 905                 910         
Lys Asp Glu Cys Thr Pro Thr Arg Lys Glu Arg Lys Arg Arg His Ser
        915                 920                 925             
Thr Ser Pro Ser Pro Ser Arg Ser Ser Ser Gly Arg Arg Val Lys Ser
    930                 935                 940                 
Pro Ser Pro Lys Ser Glu Arg Ser Glu Arg Ser Glu Arg Ser His Lys
945                 950                 955                 960 
Glu Ser Ser Arg Ser Arg Ser Ser His Lys Asp Ser Pro Arg Asp Val
                965                 970                 975     
Ser Lys Lys Ala Lys Arg Ser Pro Ser Gly Ser Arg Thr Pro Lys Arg
            980                 985                 990         
Ser Arg Arg Ser Arg Ser Arg Ser Pro Lys Lys Ser Gly Lys Lys Ser
        995                 1000                1005            
Arg Ser Gln Ser Arg Ser Pro His Arg Ser His Lys Lys Ser Lys Lys
    1010                1015                1020                
Asn Lys His
1025        


<210> 1610
<211> 1629
<212> PRT
<213> Homo sapiens

<400> 1610
Met Gln Phe Val Ser Trp Ala Thr Leu Leu Thr Leu Leu Val Arg Asp
 1               5                  10                  15      
Leu Ala Glu Met Gly Ser Pro Asp Ala Ala Ala Ala Val Arg Lys Asp
            20                  25                  30          
Arg Leu His Pro Arg Gln Val Lys Leu Leu Glu Thr Leu Gly Glu Tyr
        35                  40                  45              
Glu Ile Val Ser Pro Ile Arg Val Asn Ala Leu Gly Glu Pro Phe Pro
    50                  55                  60                  
Thr Asn Val His Phe Lys Arg Thr Arg Arg Ser Ile Asn Ser Ala Thr
65                  70                  75                  80  
Asp Pro Trp Pro Ala Phe Ala Ser Ser Ser Ser Ser Ser Thr Ser Ser
                85                  90                  95      
Gln Ala His Tyr Arg Leu Ser Ala Phe Gly Gln Gln Phe Leu Phe Asn
            100                 105                 110         
Leu Thr Ala Asn Ala Gly Phe Ile Ala Pro Leu Phe Thr Val Thr Leu
        115                 120                 125             
Leu Gly Thr Pro Gly Val Asn Gln Thr Lys Phe Tyr Ser Glu Glu Glu
    130                 135                 140                 
Ala Glu Leu Lys His Cys Phe Tyr Lys Gly Tyr Val Asn Thr Asn Ser
145                 150                 155                 160 
Glu His Thr Ala Val Ile Ser Leu Cys Ser Gly Met Leu Gly Thr Phe
                165                 170                 175     
Arg Ser His Asp Gly Asp Tyr Phe Ile Glu Pro Leu Gln Ser Met Asp
            180                 185                 190         
Glu Gln Glu Asp Glu Glu Glu Gln Asn Lys Pro His Ile Ile Tyr Arg
        195                 200                 205             
Arg Ser Ala Pro Gln Arg Glu Pro Ser Thr Gly Arg His Ala Cys Asp
    210                 215                 220                 
Thr Ser Glu His Lys Asn Arg His Ser Lys Asp Lys Lys Lys Thr Arg
225                 230                 235                 240 
Ala Arg Lys Trp Gly Glu Arg Ile Asn Leu Ala Gly Asp Val Ala Ala
                245                 250                 255     
Leu Asn Ser Gly Leu Ala Thr Glu Ala Phe Ser Ala Tyr Gly Asn Lys
            260                 265                 270         
Thr Asp Asn Thr Arg Glu Lys Arg Thr His Arg Arg Thr Lys Arg Phe
        275                 280                 285             
Leu Ser Tyr Pro Arg Phe Val Glu Val Leu Val Val Ala Asp Asn Arg
    290                 295                 300                 
Met Val Ser Tyr His Gly Glu Asn Leu Gln His Tyr Ile Leu Thr Leu
305                 310                 315                 320 
Met Ser Ile Val Ala Ser Ile Tyr Lys Asp Pro Ser Ile Gly Asn Leu
                325                 330                 335     
Ile Asn Ile Val Ile Val Asn Leu Ile Val Ile His Asn Glu Gln Asp
            340                 345                 350         
Gly Pro Ser Ile Ser Phe Asn Ala Gln Thr Thr Leu Lys Asn Phe Cys
        355                 360                 365             
Gln Trp Gln His Ser Lys Asn Ser Pro Gly Gly Ile His His Asp Thr
    370                 375                 380                 
Ala Val Leu Leu Thr Arg Gln Asp Ile Cys Arg Ala His Asp Lys Cys
385                 390                 395                 400 
Asp Thr Leu Gly Leu Ala Glu Leu Gly Thr Ile Cys Asp Pro Tyr Arg
                405                 410                 415     
Ser Cys Ser Ile Ser Glu Asp Ser Gly Leu Ser Thr Ala Phe Thr Ile
            420                 425                 430         
Ala His Glu Leu Gly His Val Phe Asn Met Pro His Asp Asp Asn Asn
        435                 440                 445             
Lys Cys Lys Glu Glu Gly Val Lys Ser Pro Gln His Val Met Ala Pro
    450                 455                 460                 
Thr Leu Asn Phe Tyr Thr Asn Pro Trp Met Trp Ser Lys Cys Ser Arg
465                 470                 475                 480 
Lys Tyr Ile Thr Glu Phe Leu Asp Thr Gly Tyr Gly Glu Cys Leu Leu
                485                 490                 495     
Asn Glu Pro Glu Ser Arg Pro Tyr Pro Leu Pro Val Gln Leu Pro Gly
            500                 505                 510         
Ile Leu Tyr Asn Val Asn Lys Gln Cys Glu Leu Ile Phe Gly Pro Gly
        515                 520                 525             
Ser Gln Val Cys Pro Tyr Met Met Gln Cys Arg Arg Leu Trp Cys Asn
    530                 535                 540                 
Asn Val Asn Gly Val His Lys Gly Cys Arg Thr Gln His Thr Pro Trp
545                 550                 555                 560 
Ala Asp Gly Thr Glu Cys Glu Pro Gly Lys His Cys Lys Tyr Gly Phe
                565                 570                 575     
Cys Val Pro Lys Glu Met Asp Val Pro Val Thr Asp Gly Ser Trp Gly
            580                 585                 590         
Ser Trp Ser Pro Phe Gly Thr Cys Ser Arg Thr Cys Gly Gly Gly Ile
        595                 600                 605             
Lys Thr Ala Ile Arg Glu Cys Asn Arg Pro Glu Pro Lys Asn Gly Gly
    610                 615                 620                 
Lys Tyr Cys Val Gly Arg Arg Met Lys Phe Lys Ser Cys Asn Thr Glu
625                 630                 635                 640 
Pro Cys Leu Lys Gln Lys Arg Asp Phe Arg Asp Glu Gln Cys Ala His
                645                 650                 655     
Phe Asp Gly Lys His Phe Asn Ile Asn Gly Leu Leu Pro Asn Val Arg
            660                 665                 670         
Trp Val Pro Lys Tyr Ser Gly Ile Leu Met Lys Asp Arg Cys Lys Leu
        675                 680                 685             
Phe Cys Arg Val Ala Gly Asn Thr Ala Tyr Tyr Gln Leu Arg Asp Arg
    690                 695                 700                 
Val Ile Asp Gly Thr Pro Cys Gly Gln Asp Thr Asn Asp Ile Cys Val
705                 710                 715                 720 
Gln Gly Leu Cys Arg Gln Ala Gly Cys Asp His Val Leu Asn Ser Lys
                725                 730                 735     
Ala Arg Arg Asp Lys Cys Gly Val Cys Gly Gly Asp Asn Ser Ser Cys
            740                 745                 750         
Lys Thr Val Ala Gly Thr Phe Asn Thr Val His Tyr Gly Tyr Asn Thr
        755                 760                 765             
Val Val Arg Ile Pro Ala Gly Ala Thr Asn Ile Asp Val Arg Gln His
    770                 775                 780                 
Ser Phe Ser Gly Glu Thr Asp Asp Asp Asn Tyr Leu Ala Leu Ser Ser
785                 790                 795                 800 
Ser Lys Gly Glu Phe Leu Leu Asn Gly Asn Phe Val Val Thr Met Ala
                805                 810                 815     
Lys Arg Glu Ile Arg Ile Gly Asn Ala Val Val Glu Tyr Ser Gly Ser
            820                 825                 830         
Glu Thr Ala Val Glu Arg Ile Asn Ser Thr Asp Arg Ile Glu Gln Glu
        835                 840                 845             
Leu Leu Leu Gln Val Leu Ser Val Gly Lys Leu Tyr Asn Pro Asp Val
    850                 855                 860                 
Arg Tyr Ser Phe Asn Ile Pro Ile Glu Asp Lys Pro Gln Gln Phe Tyr
865                 870                 875                 880 
Trp Asn Ser His Gly Pro Trp Gln Ala Cys Ser Lys Pro Cys Gln Gly
                885                 890                 895     
Glu Arg Lys Arg Lys Leu Val Cys Thr Arg Glu Ser Asp Gln Leu Thr
            900                 905                 910         
Val Ser Asp Gln Arg Cys Asp Arg Leu Pro Gln Pro Gly His Ile Thr
        915                 920                 925             
Glu Pro Cys Gly Thr Asp Cys Asp Leu Arg Trp His Val Ala Ser Arg
    930                 935                 940                 
Ser Glu Cys Ser Ala Gln Cys Gly Leu Gly Tyr Arg Thr Leu Asp Ile
945                 950                 955                 960 
Tyr Cys Ala Lys Tyr Ser Arg Leu Asp Gly Lys Thr Glu Lys Val Asp
                965                 970                 975     
Asp Gly Phe Cys Ser Ser His Pro Lys Pro Ser Asn Arg Glu Lys Cys
            980                 985                 990         
Ser Gly Glu Cys Asn Thr Gly Gly Trp Arg Tyr Ser Ala Trp Thr Glu
        995                 1000                1005            
Cys Ser Lys Ser Cys Asp Gly Gly Thr Gln Arg Arg Arg Ala Ile Cys
    1010                1015                1020                
Val Asn Thr Arg Asn Asp Val Leu Asp Asp Ser Lys Cys Thr His Gln
1025                1030                1035                1040
Glu Lys Val Thr Ile Gln Arg Cys Ser Glu Phe Pro Cys Pro Gln Trp
                1045                1050                1055    
Lys Ser Gly Asp Trp Ser Glu Cys Leu Val Thr Cys Gly Lys Gly His
            1060                1065                1070        
Lys His Arg Gln Val Trp Cys Gln Phe Gly Glu Asp Arg Leu Asn Asp
        1075                1080                1085            
Arg Met Cys Asp Pro Glu Thr Lys Pro Thr Ser Met Gln Thr Cys Gln
    1090                1095                1100                
Gln Pro Glu Cys Ala Ser Trp Gln Ala Gly Pro Trp Gly Gln Cys Ser
1105                1110                1115                1120
Val Thr Cys Gly Gln Gly Tyr Gln Leu Arg Ala Val Lys Cys Ile Ile
                1125                1130                1135    
Gly Thr Tyr Met Ser Val Val Asp Asp Asn Asp Cys Asn Ala Ala Thr
            1140                1145                1150        
Arg Pro Thr Asp Thr Gln Asp Cys Glu Leu Pro Ser Cys His Pro Pro
        1155                1160                1165            
Pro Ala Ala Pro Glu Thr Arg Arg Ser Thr Tyr Ser Ala Pro Arg Thr
    1170                1175                1180                
Gln Trp Arg Phe Gly Ser Trp Thr Pro Cys Ser Ala Thr Cys Gly Lys
1185                1190                1195                1200
Gly Thr Arg Met Arg Tyr Val Ser Cys Arg Asp Glu Asn Gly Ser Val
                1205                1210                1215    
Ala Asp Glu Ser Ala Cys Ala Thr Leu Pro Arg Pro Val Ala Lys Glu
            1220                1225                1230        
Glu Cys Ser Val Thr Pro Cys Gly Gln Trp Lys Ala Leu Asp Trp Ser
        1235                1240                1245            
Ser Cys Ser Val Thr Cys Gly Gln Gly Arg Ala Thr Arg Gln Val Met
    1250                1255                1260                
Cys Val Asn Tyr Ser Asp His Val Ile Asp Arg Ser Glu Cys Asp Gln
1265                1270                1275                1280
Asp Tyr Ile Pro Glu Thr Asp Gln Asp Cys Ser Met Ser Pro Cys Pro
                1285                1290                1295    
Gln Arg Thr Pro Asp Ser Gly Leu Ala Gln His Pro Phe Gln Asn Glu
            1300                1305                1310        
Asp Tyr Arg Pro Arg Ser Ala Ser Pro Ser Arg Thr His Val Leu Gly
        1315                1320                1325            
Gly Asn Gln Trp Arg Thr Gly Pro Trp Gly Ala Cys Ser Ser Thr Cys
    1330                1335                1340                
Ala Gly Gly Ser Gln Arg Arg Val Val Val Cys Gln Asp Glu Asn Gly
1345                1350                1355                1360
Tyr Thr Ala Asn Asp Cys Val Glu Arg Ile Lys Pro Asp Glu Gln Arg
                1365                1370                1375    
Ala Cys Glu Ser Gly Pro Cys Pro Gln Trp Ala Tyr Gly Asn Trp Gly
            1380                1385                1390        
Glu Cys Thr Lys Leu Cys Gly Gly Gly Ile Arg Thr Arg Leu Val Val
        1395                1400                1405            
Cys Gln Arg Ser Asn Gly Glu Arg Phe Pro Asp Leu Ser Cys Glu Ile
    1410                1415                1420                
Leu Asp Lys Pro Pro Asp Arg Glu Gln Cys Asn Thr His Ala Cys Pro
1425                1430                1435                1440
His Asp Ala Ala Trp Ser Thr Gly Pro Trp Ser Ser Cys Ser Val Ser
                1445                1450                1455    
Cys Gly Arg Gly His Lys Gln Arg Asn Val Tyr Cys Met Ala Lys Asp
            1460                1465                1470        
Gly Ser His Leu Glu Ser Asp Tyr Cys Lys His Leu Ala Lys Pro His
        1475                1480                1485            
Gly His Arg Lys Cys Arg Gly Gly Arg Cys Pro Lys Trp Lys Ala Gly
    1490                1495                1500                
Ala Trp Ser Gln Cys Ser Val Ser Cys Gly Arg Gly Val Gln Gln Arg
1505                1510                1515                1520
His Val Gly Cys Gln Ile Gly Thr His Lys Ile Ala Arg Glu Thr Glu
                1525                1530                1535    
Cys Asn Pro Tyr Thr Arg Pro Glu Ser Glu Arg Asp Cys Gln Gly Pro
            1540                1545                1550        
Arg Cys Pro Leu Tyr Thr Trp Arg Ala Glu Glu Trp Gln Glu Cys Thr
        1555                1560                1565            
Lys Thr Cys Gly Glu Gly Ser Arg Tyr Arg Lys Val Val Cys Val Asp
    1570                1575                1580                
Asp Asn Lys Asn Glu Val His Gly Ala Arg Cys Asp Val Ser Lys Arg
1585                1590                1595                1600
Pro Val Asp Arg Glu Ser Cys Ser Leu Gln Pro Cys Glu Tyr Val Trp
                1605                1610                1615    
Ile Thr Gly Glu Trp Ser Glu Val Pro Ser Trp Glu Leu
            1620                1625                


<210> 1611
<211> 331
<212> PRT
<213> Homo sapiens

<400> 1611
Met Ser Arg Gln Leu Ser Arg Ala Arg Pro Ala Thr Val Leu Gly Ala
 1               5                  10                  15      
Met Glu Met Gly Arg Arg Met Asp Ala Pro Thr Ser Ala Ala Val Thr
            20                  25                  30          
Arg Ala Phe Leu Glu Arg Gly His Thr Glu Ile Asp Thr Ala Phe Val
        35                  40                  45              
Tyr Ser Glu Gly Gln Ser Glu Thr Ile Leu Gly Gly Leu Gly Leu Arg
    50                  55                  60                  
Leu Gly Gly Ser Asp Cys Arg Val Lys Ile Asp Thr Lys Ala Ile Pro
65                  70                  75                  80  
Leu Phe Gly Asn Ser Leu Lys Pro Asp Ser Leu Arg Phe Gln Leu Glu
                85                  90                  95      
Thr Ser Leu Lys Arg Leu Gln Cys Pro Arg Val Asp Leu Phe Tyr Leu
            100                 105                 110         
His Met Pro Asp His Ser Thr Pro Val Glu Glu Thr Leu Arg Ala Cys
        115                 120                 125             
His Gln Leu His Gln Glu Gly Lys Phe Val Glu Leu Gly Leu Ser Asn
    130                 135                 140                 
Tyr Ala Ala Trp Glu Val Ala Glu Ile Cys Thr Leu Cys Lys Ser Asn
145                 150                 155                 160 
Gly Trp Ile Leu Pro Thr Val Tyr Gln Gly Met Tyr Asn Ala Ile Thr
                165                 170                 175     
Arg Gln Val Glu Thr Glu Leu Phe Pro Cys Leu Arg His Phe Gly Leu
            180                 185                 190         
Arg Phe Tyr Ala Phe Asn Pro Leu Ala Gly Gly Leu Leu Thr Gly Lys
        195                 200                 205             
Tyr Lys Tyr Glu Asp Lys Asn Gly Lys Gln Pro Val Gly Arg Phe Phe
    210                 215                 220                 
Gly Asn Thr Trp Ala Glu Met Tyr Arg Asn Arg Tyr Trp Lys Glu His
225                 230                 235                 240 
His Phe Glu Gly Ile Ala Leu Val Glu Lys Ala Leu Gln Ala Ala Tyr
                245                 250                 255     
Gly Ala Ser Ala Pro Ser Met Thr Ser Ala Thr Leu Arg Trp Met Tyr
            260                 265                 270         
His His Ser Gln Leu Gln Gly Ala His Gly Asp Ala Val Ile Leu Gly
        275                 280                 285             
Met Ser Ser Leu Glu Gln Leu Glu Gln Asn Leu Ala Ala Ala Glu Glu
    290                 295                 300                 
Gly Pro Leu Glu Pro Ala Val Val Asp Ala Phe Asn Gln Ala Trp His
305                 310                 315                 320 
Leu Val Thr His Glu Cys Pro Asn Tyr Phe Arg
                325                 330     


<210> 1612
<211> 1023
<212> PRT
<213> Homo sapiens

<400> 1612
Met Phe His Leu Arg Thr Cys Ala Ala Lys Leu Arg Pro Leu Thr Ala
 1               5                  10                  15      
Ser Gln Thr Val Lys Thr Phe Ser Gln Asn Arg Pro Ala Ala Ala Arg
            20                  25                  30          
Thr Phe Gln Gln Ile Arg Cys Tyr Ser Ala Pro Val Ala Ala Glu Pro
        35                  40                  45              
Phe Leu Ser Gly Thr Ser Ser Asn Tyr Val Glu Glu Met Tyr Cys Ala
    50                  55                  60                  
Trp Leu Glu Asn Pro Lys Ser Val His Lys Ser Trp Asp Ile Phe Phe
65                  70                  75                  80  
Arg Asn Thr Asn Ala Gly Ala Pro Pro Gly Thr Ala Tyr Gln Ser Pro
                85                  90                  95      
Leu Pro Leu Ser Arg Gly Ser Leu Ala Ala Val Ala His Ala Gln Ser
            100                 105                 110         
Leu Val Glu Ala Gln Pro Asn Val Asp Lys Leu Val Glu Asp His Leu
        115                 120                 125             
Ala Val Gln Ser Leu Ile Arg Ala Tyr Gln Ile Arg Gly His His Val
    130                 135                 140                 
Ala Gln Leu Asp Pro Leu Gly Ile Leu Asp Ala Asp Leu Asp Ser Ser
145                 150                 155                 160 
Val Pro Ala Asp Ile Ile Ser Ser Thr Asp Lys Leu Gly Phe Tyr Gly
                165                 170                 175     
Leu Asp Glu Ser Asp Leu Asp Lys Val Phe His Leu Pro Thr Thr Thr
            180                 185                 190         
Phe Ile Gly Gly Gln Glu Ser Ala Leu Pro Leu Arg Glu Ile Ile Arg
        195                 200                 205             
Arg Leu Glu Met Ala Tyr Cys Gln His Ile Gly Val Glu Phe Met Phe
    210                 215                 220                 
Ile Asn Asp Leu Glu Gln Cys Gln Trp Ile Arg Gln Lys Phe Glu Thr
225                 230                 235                 240 
Pro Gly Ile Met Gln Phe Thr Asn Glu Glu Lys Arg Thr Leu Leu Ala
                245                 250                 255     
Arg Leu Val Arg Ser Thr Arg Phe Glu Glu Phe Leu Gln Arg Lys Trp
            260                 265                 270         
Ser Ser Glu Lys Arg Phe Gly Leu Glu Gly Cys Glu Val Leu Ile Pro
        275                 280                 285             
Ala Leu Lys Thr Ile Ile Asp Lys Ser Ser Glu Asn Gly Val Asp Tyr
    290                 295                 300                 
Val Ile Met Gly Met Pro His Arg Gly Arg Leu Asn Val Leu Ala Asn
305                 310                 315                 320 
Val Ile Arg Lys Glu Leu Glu Gln Ile Phe Cys Gln Phe Asp Ser Lys
                325                 330                 335     
Leu Glu Ala Ala Asp Glu Gly Ser Gly Asp Val Lys Tyr His Leu Gly
            340                 345                 350         
Met Tyr His Arg Arg Ile Asn Arg Val Thr Asp Arg Asn Ile Thr Leu
        355                 360                 365             
Ser Leu Val Ala Asn Pro Ser His Leu Glu Ala Ala Asp Pro Val Val
    370                 375                 380                 
Met Gly Lys Thr Lys Ala Glu Gln Phe Tyr Cys Gly Asp Thr Glu Gly
385                 390                 395                 400 
Lys Lys Val Met Ser Ile Leu Leu His Gly Asp Ala Ala Phe Ala Gly
                405                 410                 415     
Gln Gly Ile Val Tyr Glu Thr Phe His Leu Ser Asp Leu Pro Ser Tyr
            420                 425                 430         
Thr Thr His Gly Thr Val His Val Val Val Asn Asn Gln Ile Gly Phe
        435                 440                 445             
Thr Thr Asp Pro Arg Met Ala Arg Ser Ser Pro Tyr Pro Thr Asp Val
    450                 455                 460                 
Ala Arg Val Val Asn Ala Pro Ile Phe His Val Asn Ser Asp Asp Pro
465                 470                 475                 480 
Glu Ala Val Met Tyr Val Cys Lys Val Ala Ala Glu Trp Arg Ser Thr
                485                 490                 495     
Phe His Lys Asp Val Val Val Asp Leu Val Cys Tyr Arg Arg Asn Gly
            500                 505                 510         
His Asn Glu Met Asp Glu Pro Met Phe Thr Gln Pro Leu Met Tyr Lys
        515                 520                 525             
Gln Ile Arg Lys Gln Lys Pro Val Leu Gln Lys Tyr Ala Glu Leu Leu
    530                 535                 540                 
Val Ser Gln Gly Val Val Asn Gln Pro Glu Tyr Glu Glu Glu Ile Ser
545                 550                 555                 560 
Lys Tyr Asp Lys Ile Cys Glu Glu Ala Phe Ala Arg Ser Lys Asp Glu
                565                 570                 575     
Lys Ile Leu His Ile Lys His Trp Leu Asp Ser Pro Trp Pro Gly Phe
            580                 585                 590         
Phe Thr Leu Asp Gly Gln Pro Arg Ser Met Ser Cys Pro Ser Thr Gly
        595                 600                 605             
Leu Thr Glu Asp Ile Leu Thr His Ile Gly Asn Val Ala Ser Ser Val
    610                 615                 620                 
Pro Val Glu Asn Phe Thr Ile His Gly Gly Leu Ser Arg Ile Leu Lys
625                 630                 635                 640 
Thr Arg Gly Glu Met Val Lys Asn Arg Thr Val Asp Trp Ala Leu Ala
                645                 650                 655     
Glu Tyr Met Ala Phe Gly Ser Leu Leu Lys Glu Gly Ile His Ile Arg
            660                 665                 670         
Leu Ser Gly Gln Asp Val Glu Arg Gly Thr Phe Ser His Arg His His
        675                 680                 685             
Val Leu His Asp Gln Asn Val Asp Lys Arg Thr Cys Ile Pro Met Asn
    690                 695                 700                 
His Leu Trp Pro Asn Gln Ala Pro Tyr Thr Val Cys Asn Ser Ser Leu
705                 710                 715                 720 
Ser Glu Tyr Gly Val Leu Gly Phe Glu Leu Gly Phe Ala Met Ala Ser
                725                 730                 735     
Pro Asn Ala Leu Val Leu Trp Glu Ala Gln Phe Gly Asp Phe His Asn
            740                 745                 750         
Thr Ala Gln Cys Ile Ile Asp Gln Phe Ile Cys Pro Gly Gln Ala Lys
        755                 760                 765             
Trp Val Arg Gln Asn Gly Ile Val Leu Leu Leu Pro His Gly Met Glu
    770                 775                 780                 
Gly Met Gly Pro Glu His Ser Ser Ala Arg Pro Glu Arg Phe Leu Gln
785                 790                 795                 800 
Met Cys Asn Asp Asp Pro Asp Val Leu Pro Asp Leu Lys Glu Ala Asn
                805                 810                 815     
Phe Asp Ile Asn Gln Leu Tyr Asp Cys Asn Trp Val Val Val Asn Cys
            820                 825                 830         
Ser Thr Pro Gly Asn Phe Phe His Val Leu Arg Arg Gln Ile Leu Leu
        835                 840                 845             
Pro Phe Arg Lys Pro Leu Ile Ile Phe Thr Pro Lys Ser Leu Leu Arg
    850                 855                 860                 
His Pro Glu Ala Arg Ser Ser Phe Asp Glu Met Leu Pro Gly Thr His
865                 870                 875                 880 
Phe Gln Arg Val Ile Pro Glu Asp Gly Pro Ala Ala Gln Asn Pro Glu
                885                 890                 895     
Asn Val Lys Arg Leu Leu Phe Cys Thr Gly Lys Val Tyr Tyr Asp Leu
            900                 905                 910         
Thr Arg Glu Arg Lys Ala Arg Asp Met Val Gly Gln Val Ala Ile Thr
        915                 920                 925             
Arg Ile Glu Gln Leu Ser Pro Phe Pro Phe Asp Leu Leu Leu Lys Glu
    930                 935                 940                 
Val Gln Lys Tyr Pro Asn Ala Glu Leu Ala Trp Cys Gln Glu Glu His
945                 950                 955                 960 
Lys Asn Gln Gly Tyr Tyr Asp Tyr Val Lys Pro Arg Leu Arg Thr Thr
                965                 970                 975     
Ile Ser Arg Ala Lys Pro Val Trp Tyr Ala Gly Arg Asp Pro Ala Ala
            980                 985                 990         
Ala Pro Ala Thr Gly Asn Lys Lys Thr His Leu Thr Glu Leu Gln Arg
        995                 1000                1005            
Leu Leu Asp Thr Ala Phe Asp Leu Asp Val Phe Lys Asn Phe Ser
    1010                1015                1020            


<210> 1613
<211> 725
<212> PRT
<213> Homo sapiens

<400> 1613
Met Ala Asp Glu Asp Leu Ile Phe Arg Leu Glu Gly Val Asp Gly Gly
 1               5                  10                  15      
Gln Ser Pro Arg Ala Gly His Asp Gly Asp Ser Asp Gly Asp Ser Asp
            20                  25                  30          
Asp Glu Glu Gly Tyr Phe Ile Cys Pro Ile Thr Asp Asp Pro Ser Ser
        35                  40                  45              
Asn Gln Asn Val Asn Ser Lys Val Asn Lys Tyr Tyr Ser Asn Leu Thr
    50                  55                  60                  
Lys Ser Glu Arg Tyr Ser Ser Ser Gly Ser Pro Ala Asn Ser Phe His
65                  70                  75                  80  
Phe Lys Glu Ala Trp Lys His Ala Ile Gln Lys Ala Lys His Met Pro
                85                  90                  95      
Asp Pro Trp Ala Glu Phe His Leu Glu Asp Ile Ala Thr Glu Arg Ala
            100                 105                 110         
Thr Arg His Arg Tyr Asn Ala Val Thr Gly Glu Trp Leu Asp Asp Glu
        115                 120                 125             
Val Leu Ile Lys Met Ala Ser Gln Pro Phe Gly Arg Gly Ala Met Arg
    130                 135                 140                 
Glu Cys Phe Arg Thr Lys Lys Leu Ser Asn Phe Leu His Ala Gln Gln
145                 150                 155                 160 
Trp Lys Gly Ala Ser Asn Tyr Val Ala Lys Arg Tyr Ile Glu Pro Val
                165                 170                 175     
Asp Arg Asp Val Tyr Phe Glu Asp Val Arg Leu Gln Met Glu Ala Lys
            180                 185                 190         
Leu Trp Gly Glu Glu Tyr Asn Arg His Lys Pro Pro Lys Gln Val Asp
        195                 200                 205             
Ile Met Gln Met Cys Ile Ile Glu Leu Lys Asp Arg Pro Gly Lys Pro
    210                 215                 220                 
Leu Phe His Leu Glu His Tyr Ile Glu Gly Lys Tyr Ile Lys Tyr Asn
225                 230                 235                 240 
Ser Asn Ser Gly Phe Val Arg Asp Asp Asn Ile Arg Leu Thr Pro Gln
                245                 250                 255     
Ala Phe Ser His Phe Thr Phe Glu Arg Ser Gly His Gln Leu Ile Val
            260                 265                 270         
Val Asp Ile Gln Gly Val Gly Asp Leu Tyr Thr Asp Pro Gln Ile His
        275                 280                 285             
Thr Glu Thr Gly Thr Asp Phe Gly Asp Gly Asn Leu Gly Val Arg Gly
    290                 295                 300                 
Met Ala Leu Phe Phe Tyr Ser His Ala Cys Asn Arg Ile Cys Glu Ser
305                 310                 315                 320 
Met Gly Leu Ala Pro Phe Asp Leu Ser Pro Arg Glu Arg Asp Ala Val
                325                 330                 335     
Asn Gln Asn Thr Lys Leu Leu Gln Ser Ala Lys Thr Ile Leu Arg Gly
            340                 345                 350         
Thr Glu Glu Lys Cys Gly Ser Pro Gln Val Arg Thr Leu Ser Gly Ser
        355                 360                 365             
Arg Pro Pro Leu Leu Arg Pro Leu Ser Glu Asn Ser Gly Asp Glu Asn
    370                 375                 380                 
Met Ser Asp Val Thr Phe Asp Ser Leu Pro Ser Ser Pro Ser Ser Ala
385                 390                 395                 400 
Thr Pro His Ser Gln Lys Leu Asp His Leu His Trp Pro Val Phe Ser
                405                 410                 415     
Asp Leu Asp Asn Met Ala Ser Arg Asp His Asp His Leu Asp Asn His
            420                 425                 430         
Arg Glu Ser Glu Asn Ser Gly Asp Ser Gly Tyr Pro Ser Glu Lys Arg
        435                 440                 445             
Gly Glu Leu Asp Asp Pro Glu Pro Arg Glu His Gly His Ser Tyr Ser
    450                 455                 460                 
Asn Arg Lys Tyr Glu Ser Asp Glu Asp Ser Leu Gly Ser Ser Gly Arg
465                 470                 475                 480 
Val Cys Val Glu Lys Trp Asn Leu Leu Asn Ser Ser Arg Leu His Leu
                485                 490                 495     
Pro Arg Ala Ser Ala Val Ala Leu Glu Val Gln Arg Leu Asn Ala Leu
            500                 505                 510         
Asp Leu Glu Lys Lys Ile Gly Lys Ser Ile Leu Gly Lys Val His Leu
        515                 520                 525             
Ala Met Val Arg Tyr His Glu Gly Gly Arg Phe Cys Glu Lys Gly Glu
    530                 535                 540                 
Glu Trp Asp Gln Glu Ser Ala Val Phe His Leu Glu His Ala Ala Asn
545                 550                 555                 560 
Leu Gly Glu Leu Glu Ala Ile Val Gly Leu Gly Leu Met Tyr Ser Gln
                565                 570                 575     
Leu Pro His His Ile Leu Ala Asp Val Ser Leu Lys Glu Thr Glu Glu
            580                 585                 590         
Asn Lys Thr Lys Gly Phe Asp Tyr Leu Leu Lys Ala Ala Glu Ala Gly
        595                 600                 605             
Asp Arg Gln Ser Met Ile Leu Val Ala Arg Ala Phe Asp Ser Gly Gln
    610                 615                 620                 
Asn Leu Ser Pro Asp Arg Cys Gln Asp Trp Leu Glu Ala Leu His Trp
625                 630                 635                 640 
Tyr Asn Thr Ala Leu Glu Met Thr Asp Cys Asp Glu Gly Gly Glu Tyr
                645                 650                 655     
Asp Gly Met Gln Asp Glu Pro Arg Tyr Met Met Leu Ala Arg Glu Ala
            660                 665                 670         
Glu Met Leu Phe Thr Gly Gly Tyr Gly Leu Glu Lys Asp Pro Gln Arg
        675                 680                 685             
Ser Gly Asp Leu Tyr Thr Gln Ala Ala Glu Ala Ala Met Glu Ala Met
    690                 695                 700                 
Lys Gly Arg Leu Ala Asn Gln Tyr Tyr Gln Lys Ala Glu Glu Ala Trp
705                 710                 715                 720 
Ala Gln Met Glu Glu
                725 


<210> 1614
<211> 64
<212> PRT
<213> Homo sapiens

<400> 1614
Met Ala Lys Tyr Tyr Ala Ser Glu Ile Ala Gly Gln Thr Thr Ser Lys
 1               5                  10                  15      
Cys Ile Glu Trp Met Gly Gly Val Gly Tyr Thr Lys Asp Tyr Pro Val
            20                  25                  30          
Glu Lys Tyr Phe Arg Asp Ala Lys Ile Gly Thr Ile Tyr Glu Gly Ala
        35                  40                  45              
Ser Asn Ile Gln Leu Asn Thr Ile Ala Lys His Ile Asp Ala Glu Tyr
    50                  55                  60                  


<210> 1615
<211> 713
<212> PRT
<213> Homo sapiens

<400> 1615
Met Gly Arg Gly Ala Gly Arg Glu Tyr Ser Pro Ala Ala Thr Thr Ala
 1               5                  10                  15      
Glu Asn Gly Gly Gly Lys Lys Lys Gln Lys Glu Lys Glu Leu Asp Glu
            20                  25                  30          
Leu Lys Lys Glu Val Ala Met Asp Asp His Lys Leu Ser Leu Asp Glu
        35                  40                  45              
Leu Gly Arg Lys Tyr Gln Val Asp Leu Ser Lys Gly Leu Thr Asn Gln
    50                  55                  60                  
Arg Ala Gln Asp Val Leu Ala Arg Asp Gly Pro Asn Ala Leu Thr Pro
65                  70                  75                  80  
Pro Pro Thr Thr Pro Glu Trp Val Lys Phe Cys Arg Gln Leu Phe Gly
                85                  90                  95      
Gly Phe Ser Ile Leu Leu Trp Ile Gly Ala Ile Leu Cys Phe Leu Ala
            100                 105                 110         
Tyr Gly Ile Gln Ala Ala Met Glu Asp Glu Pro Ser Asn Asp Asn Leu
        115                 120                 125             
Tyr Leu Gly Val Val Leu Ala Ala Val Val Ile Val Thr Gly Cys Phe
    130                 135                 140                 
Ser Tyr Tyr Gln Glu Ala Lys Ser Ser Lys Ile Met Asp Ser Phe Lys
145                 150                 155                 160 
Asn Met Val Pro Gln Gln Ala Leu Val Ile Arg Glu Gly Glu Lys Met
                165                 170                 175     
Gln Ile Asn Ala Glu Glu Val Val Val Gly Asp Leu Val Glu Val Lys
            180                 185                 190         
Gly Gly Asp Arg Val Pro Ala Asp Leu Arg Ile Ile Ser Ser His Gly
        195                 200                 205             
Cys Lys Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro Gln Thr
    210                 215                 220                 
Arg Ser Pro Glu Phe Thr His Glu Asn Pro Leu Glu Thr Arg Asn Ile
225                 230                 235                 240 
Cys Phe Phe Ser Thr Asn Cys Val Glu Gly Thr Ala Arg Gly Ile Val
                245                 250                 255     
Ile Ala Thr Gly Asp Arg Thr Val Met Gly Arg Ile Ala Thr Leu Ala
            260                 265                 270         
Ser Gly Leu Glu Val Gly Arg Thr Pro Ile Ala Met Glu Ile Glu His
        275                 280                 285             
Phe Ile Gln Leu Ile Thr Gly Val Ala Val Phe Leu Gly Val Ser Phe
    290                 295                 300                 
Phe Val Leu Ser Leu Ile Leu Gly Tyr Ser Trp Leu Glu Ala Val Ile
305                 310                 315                 320 
Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly Leu Leu Ala
                325                 330                 335     
Thr Val Thr Val Cys Leu Thr Leu Thr Ala Lys Arg Met Ala Arg Lys
            340                 345                 350         
Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly Ser Thr
        355                 360                 365             
Ser Thr Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn Arg Met
    370                 375                 380                 
Thr Val Ala His Met Trp Phe Asp Asn Gln Ile His Glu Ala Asp Thr
385                 390                 395                 400 
Thr Glu Asp Gln Ser Gly Ala Thr Phe Asp Lys Arg Ser Pro Thr Trp
                405                 410                 415     
Thr Ala Leu Ser Arg Ile Ala Gly Leu Cys Asn Arg Ala Val Phe Lys
            420                 425                 430         
Ala Gly Gln Glu Asn Ile Ser Val Ser Lys Arg Asp Thr Ala Gly Asp
        435                 440                 445             
Ala Ser Glu Ser Ala Leu Leu Lys Cys Ile Glu Leu Ser Cys Gly Ser
    450                 455                 460                 
Val Arg Lys Met Arg Asp Arg Asn Pro Lys Val Ala Glu Ile Pro Phe
465                 470                 475                 480 
Asn Ser Thr Asn Lys Tyr Gln Leu Ser Ile His Glu Arg Glu Asp Ser
                485                 490                 495     
Pro Gln Ser His Val Leu Val Met Lys Gly Ala Pro Glu Arg Ile Leu
            500                 505                 510         
Asp Arg Cys Ser Thr Ile Leu Val Gln Gly Lys Glu Ile Pro Leu Asp
        515                 520                 525             
Lys Glu Met Gln Asp Ala Phe Gln Asn Ala Tyr Met Glu Leu Gly Gly
    530                 535                 540                 
Leu Gly Glu Arg Val Leu Gly Phe Cys Gln Leu Asn Leu Pro Ser Gly
545                 550                 555                 560 
Lys Phe Pro Arg Gly Phe Lys Phe Asp Thr Asp Glu Leu Asn Phe Pro
                565                 570                 575     
Thr Glu Lys Leu Cys Phe Val Gly Leu Met Ser Met Ile Asp Pro Pro
            580                 585                 590         
Arg Ala Ala Val Pro Asp Ala Val Gly Lys Cys Arg Ser Ala Gly Ile
        595                 600                 605             
Lys Val Ile Met Val Thr Gly Asp His Pro Ile Thr Ala Lys Ala Ile
    610                 615                 620                 
Ala Lys Gly Val Gly Ile Ile Ser Glu Gly Asn Glu Thr Val Glu Asp
625                 630                 635                 640 
Ile Ala Ala Arg Leu Asn Ile Pro Met Ser Gln Val Asn Pro Arg Glu
                645                 650                 655     
Ala Lys Ala Cys Val Val His Gly Ser Asp Leu Lys Asp Met Thr Ser
            660                 665                 670         
Glu Gln Leu Asp Glu Ile Leu Lys Asn His Thr Glu Ile Val Phe Ala
        675                 680                 685             
Arg Thr Ser Pro Gln Gln Lys Leu Ile Ile Val Glu Gly Cys Gln Arg
    690                 695                 700                 
Gln Gly Ser His Cys Gly Arg Asp Gly
705                 710             


<210> 1616
<211> 925
<212> PRT
<213> Homo sapiens

<400> 1616
Met Pro His Lys Ile Gly Phe Val Val Val Ser Ser Ser Gly His Glu
 1               5                  10                  15      
Asp Gly Phe Ser Ala Arg Glu Leu Met Ile His Ala Pro Thr Val Ser
            20                  25                  30          
Gly Trp Arg Ser Pro Arg Phe Cys Gln Phe Pro Gln Glu Ile Val Leu
        35                  40                  45              
Gln Met Val Glu Arg Cys Arg Ile Arg Lys Leu Gln Leu Leu Ala His
    50                  55                  60                  
Gln Tyr Met Ile Ser Ser Lys Ile Glu Phe Tyr Ile Ser Glu Ser Leu
65                  70                  75                  80  
Pro Glu Tyr Phe Ala Pro Tyr Gln Ala Glu Arg Phe Arg Arg Leu Gly
                85                  90                  95      
Tyr Val Ser Leu Cys Asp Asn Glu Lys Thr Gly Cys Lys Ala Arg Glu
            100                 105                 110         
Leu Lys Ser Val Tyr Val Asp Ala Val Gly Gln Phe Leu Lys Leu Ile
        115                 120                 125             
Phe His Gln Asn His Val Asn Lys Tyr Asn Ile Tyr Asn Gln Val Ala
    130                 135                 140                 
Leu Val Ala Ile Asn Ile Ile Gly Asp Pro Ala Asp Phe Ser Asp Glu
145                 150                 155                 160 
Ser Asn Thr Ala Ser Arg Glu Lys Leu Ile Asp His Tyr Leu Gly His
                165                 170                 175     
Asn Ser Glu Asp Pro Ala Leu Glu Gly Thr Tyr Ala Arg Lys Ser Asp
            180                 185                 190         
Tyr Ile Ser Pro Leu Asp Asp Leu Ala Phe Asp Met Tyr Gln Asp Pro
        195                 200                 205             
Glu Val Ala Gln Ile Ile Arg Lys Leu Asp Glu Arg Lys Arg Glu Ala
    210                 215                 220                 
Val Gln Lys Glu Arg Tyr Asp Tyr Ala Lys Lys Leu Lys Gln Ala Ile
225                 230                 235                 240 
Ala Asp Leu Gln Lys Val Gly Glu Arg Leu Gly Arg Tyr Glu Val Glu
                245                 250                 255     
Lys Arg Cys Ala Val Glu Lys Glu Asp Tyr Asp Leu Ala Lys Glu Lys
            260                 265                 270         
Lys Gln Gln Met Glu Gln Tyr Arg Ala Glu Val Tyr Glu Gln Leu Glu
        275                 280                 285             
Leu His Ser Leu Leu Asp Ala Glu Leu Met Arg Arg Pro Phe Asp Leu
    290                 295                 300                 
Pro Leu Gln Pro Leu Ala Arg Ser Gly Ser Pro Cys His Gln Lys Pro
305                 310                 315                 320 
Met Pro Ser Leu Pro Gln Leu Glu Glu Arg Gly Thr Glu Asn Gln Phe
                325                 330                 335     
Ala Glu Pro Phe Leu Gln Glu Lys Pro Ser Ser Tyr Ser Leu Thr Ile
            340                 345                 350         
Ser Pro Gln His Ser Ala Val Asp Pro Leu Leu Pro Ala Thr Asp Pro
        355                 360                 365             
His Pro Lys Ile Asn Ala Glu Ser Leu Pro Tyr Asp Glu Arg Pro Leu
    370                 375                 380                 
Pro Ala Ile Arg Lys His Tyr Gly Glu Ala Val Val Glu Pro Glu Met
385                 390                 395                 400 
Ser Asn Ala Asp Ile Ser Asp Ala Arg Arg Gly Gly Met Ile Gly Glu
                405                 410                 415     
Pro Glu Pro Leu Thr Glu Lys Ala Leu Arg Glu Ala Ser Ser Ala Ile
            420                 425                 430         
Asp Val Leu Gly Glu Thr Leu Val Ala Glu Ala Tyr Cys Lys Thr Trp
        435                 440                 445             
Ser Tyr Arg Glu Asp Ala Leu Leu Ala Leu Ser Lys Lys Leu Met Glu
    450                 455                 460                 
Met Pro Val Gly Thr Pro Lys Glu Asp Leu Lys Asn Thr Leu Arg Ala
465                 470                 475                 480 
Ser Val Phe Leu Val Arg Arg Ala Ile Lys Asp Ile Val Thr Ser Val
                485                 490                 495     
Phe Gln Ala Ser Leu Lys Leu Leu Lys Met Ile Ile Thr Gln Tyr Ile
            500                 505                 510         
Pro Lys His Lys Leu Ser Lys Leu Glu Thr Ala His Cys Val Glu Arg
        515                 520                 525             
Thr Ile Pro Val Leu Leu Thr Arg Thr Gly Asp Ser Ser Ala Arg Leu
    530                 535                 540                 
Arg Val Thr Ala Ala Asn Phe Ile Gln Glu Met Ala Leu Phe Lys Glu
545                 550                 555                 560 
Val Lys Ser Leu Gln Ile Ile Pro Ser Tyr Leu Val Gln Pro Leu Lys
                565                 570                 575     
Ala Asn Ser Ser Val His Leu Ala Met Ser Gln Met Gly Leu Leu Ala
            580                 585                 590         
Arg Leu Leu Lys Asp Leu Gly Thr Gly Ser Ser Gly Phe Thr Ile Asp
        595                 600                 605             
Asn Val Met Lys Phe Ser Val Ser Ala Leu Glu His Arg Val Tyr Glu
    610                 615                 620                 
Val Arg Glu Thr Ala Val Arg Ile Ile Leu Asp Met Tyr Arg Gln His
625                 630                 635                 640 
Gln Ala Ser Ile Leu Glu Tyr Leu Pro Pro Asp Asp Ser Asn Thr Arg
                645                 650                 655     
Arg Asn Ile Leu Tyr Lys Thr Ile Phe Glu Gly Phe Ala Lys Ile Asp
            660                 665                 670         
Gly Arg Ala Thr Asp Ala Glu Met Arg Ala Arg Arg Lys Ala Ala Thr
        675                 680                 685             
Glu Glu Ala Glu Lys Gln Lys Lys Glu Glu Ile Lys Ala Leu Gln Gly
    690                 695                 700                 
Gln Leu Ala Ala Leu Lys Glu Ile Gln Ala Glu Val Gln Glu Lys Glu
705                 710                 715                 720 
Ser Asp Ala Val Lys Pro Lys Asn Gln Asp Ile Gln Gly Gly Lys Ala
                725                 730                 735     
Ala Pro Ala Glu Ala Leu Gly Ile Pro Asp Glu His Tyr Leu Asp Asn
            740                 745                 750         
Leu Cys Ile Phe Cys Gly Glu Arg Ser Glu Ser Phe Thr Glu Glu Gly
        755                 760                 765             
Leu Asp Leu His Tyr Trp Lys His Cys Leu Met Leu Thr Arg Cys Asp
    770                 775                 780                 
His Cys Lys Gln Val Val Glu Ile Ser Ser Leu Thr Glu His Leu Leu
785                 790                 795                 800 
Thr Glu Cys Asp Lys Lys Asp Gly Phe Gly Lys Cys Tyr Arg Cys Ser
                805                 810                 815     
Glu Ala Val Phe Lys Glu Glu Leu Pro Arg His Ile Lys His Lys Asp
            820                 825                 830         
Cys Asn Pro Ala Lys Pro Glu Lys Leu Ala Asn Arg Cys Pro Leu Cys
        835                 840                 845             
His Glu Asn Phe Ser Pro Gly Glu Glu Ala Trp Lys Ala His Leu Met
    850                 855                 860                 
Gly Pro Ala Gly Cys Thr Met Asn Leu Arg Lys Thr His Ile Leu Gln
865                 870                 875                 880 
Lys Ala Pro Ala Leu Gln Pro Gly Lys Ser Ser Ala Val Ala Ala Ser
                885                 890                 895     
Gly Pro Leu Gly Ser Lys Ala Gly Ser Lys Ile Pro Thr Pro Lys Gly
            900                 905                 910         
Gly Leu Ser Lys Ser Ser Ser Arg Thr Tyr Ala Lys Arg
        915                 920                 925 


<210> 1617
<211> 146
<212> PRT
<213> Homo sapiens

<400> 1617
Met Val Ser Val Val Lys Ser Glu Asp Phe Ser Leu Pro Ala Tyr Met
 1               5                  10                  15      
Asp Arg Arg Asp His Pro Leu Pro Glu Val Ala His Val Lys His Leu
            20                  25                  30          
Ser Ala Ser Gln Lys Ala Leu Lys Glu Lys Glu Lys Ala Ser Trp Ser
        35                  40                  45              
Ser Leu Ser Met Asp Glu Lys Val Glu Leu Tyr Arg Ile Lys Phe Lys
    50                  55                  60                  
Glu Ser Phe Ala Glu Met Asn Arg Gly Ser Asn Glu Trp Lys Thr Val
65                  70                  75                  80  
Val Gly Gly Ala Met Phe Phe Ile Gly Phe Thr Ala Leu Val Ile Met
                85                  90                  95      
Trp Gln Lys His Tyr Val Tyr Gly Pro Leu Pro Gln Ser Phe Asp Lys
            100                 105                 110         
Glu Trp Val Ala Lys Gln Thr Lys Arg Met Leu Asp Met Lys Val Asn
        115                 120                 125             
Pro Ile Gln Gly Leu Ala Ser Lys Trp Asp Tyr Glu Lys Asn Glu Trp
    130                 135                 140                 
Lys Lys
145     


<210> 1618
<211> 961
<212> PRT
<213> Homo sapiens

<400> 1618
Met His Gly His Arg Ala Pro Gly Gly Ala Gly Pro Ser Glu Pro Glu
 1               5                  10                  15      
His Pro Ala Thr Asn Pro Pro Gly Ala Ala Pro Pro Ala Cys Ala Asp
            20                  25                  30          
Ser Asp Pro Gly Ala Ser Glu Pro Gly Leu Leu Ala Arg Arg Gly Ser
        35                  40                  45              
Gly Ser Ala Leu Gly Gly Pro Leu Asp Pro Gln Phe Val Gly Pro Ser
    50                  55                  60                  
Asp Thr Ser Leu Gly Ala Ala Pro Gly His Arg Val Leu Pro Cys Gly
65                  70                  75                  80  
Pro Ser Pro Gln His His Arg Ala Leu Arg Phe Ser Tyr His Leu Glu
                85                  90                  95      
Gly Ser Gln Pro Arg Pro Gly Leu His Gln Gly Asn Arg Ile Leu Val
            100                 105                 110         
Lys Ser Leu Ser Leu Asp Pro Gly Gln Ser Leu Glu Pro His Pro Glu
        115                 120                 125             
Gly Pro Gln Arg Leu Arg Ser Asp Pro Gly Pro Pro Thr Glu Thr Pro
    130                 135                 140                 
Ser Gln Arg Pro Ser Pro Leu Lys Arg Ala Pro Gly Pro Lys Pro Gln
145                 150                 155                 160 
Val Pro Pro Lys Pro Ser Tyr Leu Gln Met Pro Arg Met Pro Pro Pro
                165                 170                 175     
Leu Glu Pro Ile Pro Pro Pro Pro Ser Arg Pro Leu Pro Ala Asp Pro
            180                 185                 190         
Arg Val Ala Lys Gly Leu Ala Pro Arg Ala Glu Ala Ser Pro Ser Ser
        195                 200                 205             
Ala Ala Val Ser Ser Leu Ile Glu Lys Phe Glu Arg Glu Pro Val Ile
    210                 215                 220                 
Val Ala Ser Asp Arg Pro Val Pro Gly Pro Ser Pro Gly Pro Pro Glu
225                 230                 235                 240 
Pro Val Met Leu Pro Gln Pro Thr Ser Gln Pro Pro Val Pro Gln Leu
                245                 250                 255     
Pro Glu Gly Glu Ala Ser Arg Cys Leu Phe Leu Leu Ala Pro Gly Pro
            260                 265                 270         
Arg Asp Gly Glu Lys Val Pro Asn Arg Asp Ser Gly Ile Asp Ser Ile
        275                 280                 285             
Ser Ser Pro Ser Asn Ser Glu Glu Thr Cys Phe Val Ser Asp Asp Gly
    290                 295                 300                 
Pro Pro Ser His Ser Leu Cys Pro Gly Pro Pro Ala Leu Ala Ser Val
305                 310                 315                 320 
Pro Val Ala Leu Ala Asp Pro His Arg Pro Gly Ser Gln Glu Val Asp
                325                 330                 335     
Ser Asp Leu Glu Glu Glu Asp Asp Glu Glu Glu Glu Glu Glu Lys Asp
            340                 345                 350         
Arg Glu Ile Pro Val Pro Leu Met Glu Arg Gln Glu Ser Val Glu Leu
        355                 360                 365             
Thr Val Gln Gln Lys Val Phe His Ile Ala Asn Glu Leu Leu Gln Thr
    370                 375                 380                 
Glu Lys Ala Tyr Val Ser Arg Leu His Leu Leu Asp Gln Val Phe Cys
385                 390                 395                 400 
Ala Arg Leu Leu Glu Glu Ala Arg Asn Arg Ser Ser Phe Pro Ala Asp
                405                 410                 415     
Val Val His Gly Ile Phe Ser Asn Ile Cys Ser Ile Tyr Cys Phe His
            420                 425                 430         
Gln Gln Phe Leu Leu Pro Glu Leu Glu Lys Arg Met Glu Glu Trp Asp
        435                 440                 445             
Arg Tyr Pro Arg Ile Gly Asp Ile Leu Gln Lys Leu Ala Pro Phe Leu
    450                 455                 460                 
Lys Met Tyr Gly Glu Tyr Val Lys Asn Phe Asp Arg Ala Val Glu Leu
465                 470                 475                 480 
Val Asn Thr Trp Thr Glu Arg Ser Thr Gln Phe Lys Val Ile Ile His
                485                 490                 495     
Glu Val Gln Lys Glu Glu Ala Cys Gly Asn Leu Thr Leu Gln His His
            500                 505                 510         
Met Leu Glu Pro Val Gln Arg Ile Pro Arg Tyr Glu Leu Leu Leu Lys
        515                 520                 525             
Asp Tyr Leu Leu Lys Leu Pro His Gly Ser Pro Asp Ser Lys Asp Ala
    530                 535                 540                 
Gln Lys Ser Leu Glu Leu Ile Ala Thr Ala Ala Glu His Ser Asn Ala
545                 550                 555                 560 
Ala Ile Arg Lys Met Glu Arg Met His Lys Leu Leu Lys Val Tyr Glu
                565                 570                 575     
Leu Leu Gly Gly Glu Glu Asp Ile Val Ser Pro Thr Lys Glu Leu Ile
            580                 585                 590         
Lys Glu Gly His Ile Leu Lys Leu Ser Ala Lys Asn Gly Thr Thr Gln
        595                 600                 605             
Asp Arg Tyr Leu Ile Leu Phe Asn Asp Arg Leu Leu Tyr Cys Val Pro
    610                 615                 620                 
Arg Leu Arg Leu Leu Gly Gln Lys Phe Ser Val Arg Ala Arg Ile Asp
625                 630                 635                 640 
Val Asp Gly Met Glu Leu Lys Glu Ser Ser Asn Leu Asn Leu Pro Arg
                645                 650                 655     
Thr Phe Leu Val Ser Gly Lys Gln Arg Ser Leu Glu Leu Gln Ala Arg
            660                 665                 670         
Thr Glu Glu Glu Lys Lys Asp Trp Val Gln Ala Ile Asn Ser Thr Leu
        675                 680                 685             
Leu Lys His Glu Gln Thr Leu Glu Thr Phe Lys Leu Leu Asn Ser Thr
    690                 695                 700                 
Asn Arg Glu Asp Glu Asp Thr Pro Pro Asn Ser Pro Asn Val Asp Leu
705                 710                 715                 720 
Gly Lys Arg Ala Pro Thr Pro Ile Arg Glu Lys Glu Val Thr Met Cys
                725                 730                 735     
Met Arg Cys Gln Glu Pro Phe Asn Ser Ile Thr Lys Arg Arg His His
            740                 745                 750         
Cys Lys Ala Cys Gly His Val Val Cys Gly Lys Cys Ser Glu Phe Arg
        755                 760                 765             
Ala Arg Leu Val Tyr Asp Asn Asn Arg Ser Asn Arg Val Cys Thr Asp
    770                 775                 780                 
Cys Tyr Val Ala Leu His Gly Val Pro Gly Ser Ser Pro Ala Cys Ser
785                 790                 795                 800 
Gln His Thr Pro Gln Arg Arg Arg Ser Ile Leu Glu Lys Gln Ala Ser
                805                 810                 815     
Val Ala Ala Glu Asn Ser Val Ile Cys Ser Phe Leu His Tyr Met Glu
            820                 825                 830         
Lys Gly Gly Lys Gly Trp His Lys Ala Trp Phe Val Val Pro Glu Asn
        835                 840                 845             
Glu Pro Leu Val Leu Tyr Ile Tyr Gly Ala Pro Gln Asp Val Lys Ala
    850                 855                 860                 
Gln Arg Ser Leu Pro Leu Ile Gly Phe Glu Val Gly Pro Pro Glu Ala
865                 870                 875                 880 
Gly Glu Arg Pro Asp Arg Arg His Val Phe Lys Ile Thr Gln Ser His
                885                 890                 895     
Leu Ser Trp Tyr Phe Ser Pro Glu Thr Glu Glu Leu Gln Arg Arg Trp
            900                 905                 910         
Met Ala Val Leu Gly Arg Ala Gly Arg Gly Asp Thr Phe Cys Pro Gly
        915                 920                 925             
Pro Thr Leu Ser Glu Asp Arg Glu Met Glu Glu Ala Pro Val Ala Ala
    930                 935                 940                 
Leu Gly Ala Thr Ala Glu Pro Pro Glu Ser Pro Gln Thr Arg Asp Lys
945                 950                 955                 960 
Thr
    


<210> 1619
<211> 474
<212> PRT
<213> Homo sapiens

<400> 1619
Met Ala Tyr Ile Gln Leu Glu Pro Leu Asn Glu Gly Phe Leu Ser Arg
 1               5                  10                  15      
Ile Ser Gly Leu Leu Leu Cys Arg Trp Thr Cys Arg His Cys Cys Gln
            20                  25                  30          
Lys Cys Tyr Glu Ser Ser Cys Cys Gln Ser Ser Glu Asp Glu Val Glu
        35                  40                  45              
Ile Leu Gly Pro Phe Pro Ala Gln Thr Pro Pro Trp Leu Met Ala Ser
    50                  55                  60                  
Arg Ser Ser Asp Lys Asp Gly Asp Ser Val His Thr Ala Ser Glu Val
65                  70                  75                  80  
Pro Leu Thr Pro Arg Thr Asn Ser Pro Asp Gly Arg Arg Ser Ser Ser
                85                  90                  95      
Asp Thr Ser Lys Ser Thr Tyr Ser Leu Thr Arg Arg Ile Ser Ser Leu
            100                 105                 110         
Glu Ser Arg Arg Pro Ser Ser Pro Leu Ile Asp Ile Lys Pro Ile Glu
        115                 120                 125             
Phe Gly Val Leu Ser Ala Lys Lys Glu Pro Ile Gln Pro Ser Val Leu
    130                 135                 140                 
Arg Arg Thr Tyr Asn Pro Asp Asp Tyr Phe Arg Lys Phe Glu Pro His
145                 150                 155                 160 
Leu Tyr Ser Leu Asp Ser Asn Ser Asp Asp Val Asp Ser Leu Thr Asp
                165                 170                 175     
Glu Glu Ile Leu Ser Lys Tyr Gln Leu Gly Met Leu His Phe Ser Thr
            180                 185                 190         
Gln Tyr Asp Leu Leu His Asn His Leu Thr Val Arg Val Ile Glu Ala
        195                 200                 205             
Arg Asp Leu Pro Pro Pro Ile Ser His Asp Gly Ser Arg Gln Asp Met
    210                 215                 220                 
Ala His Ser Asn Pro Tyr Val Lys Ile Cys Leu Leu Pro Asp Gln Lys
225                 230                 235                 240 
Asn Ser Lys Gln Thr Gly Val Lys Arg Lys Thr Gln Lys Pro Val Phe
                245                 250                 255     
Glu Glu Arg Tyr Thr Phe Glu Ile Pro Phe Leu Glu Ala Gln Arg Arg
            260                 265                 270         
Thr Leu Leu Leu Thr Val Val Asp Phe Asp Lys Phe Ser Arg His Cys
        275                 280                 285             
Val Ile Gly Lys Val Ser Val Pro Leu Cys Glu Val Asp Leu Val Lys
    290                 295                 300                 
Gly Gly His Trp Trp Lys Ala Leu Ile Pro Ser Ser Gln Asn Glu Val
305                 310                 315                 320 
Glu Leu Gly Glu Leu Leu Leu Ser Leu Asn Tyr Leu Pro Ser Ala Gly
                325                 330                 335     
Arg Leu Asn Val Asp Val Ile Arg Ala Lys Gln Leu Leu Gln Thr Asp
            340                 345                 350         
Val Ser Gln Gly Ser Asp Pro Phe Val Lys Ile Gln Leu Val His Gly
        355                 360                 365             
Leu Lys Leu Val Lys Thr Lys Lys Thr Ser Phe Leu Arg Gly Thr Ile
    370                 375                 380                 
Asp Pro Phe Tyr Asn Glu Ser Phe Ser Phe Lys Val Pro Gln Glu Glu
385                 390                 395                 400 
Leu Glu Asn Ala Ser Leu Val Phe Thr Val Phe Gly His Asn Met Lys
                405                 410                 415     
Ser Ser Asn Asp Phe Ile Gly Arg Ile Val Ile Gly Gln Tyr Ser Ser
            420                 425                 430         
Gly Pro Ser Glu Thr Asn His Trp Arg Arg Met Leu Asn Thr His Arg
        435                 440                 445             
Thr Ala Val Glu Gln Trp His Ser Leu Arg Ser Arg Ala Glu Cys Asp
    450                 455                 460                 
Arg Val Ser Pro Ala Ser Leu Glu Val Thr
465                 470                 


<210> 1620
<211> 438
<212> PRT
<213> Homo sapiens

<400> 1620
Met Gly Asp Trp His Ser Gln Gly Arg Leu Leu Thr Val Phe Val Gln
 1               5                  10                  15      
Cys Arg His Pro Pro Ala Leu Arg Gly Lys Tyr Leu Asp Tyr Leu Asp
            20                  25                  30          
Asp Gln Gln Leu Gln Asn Gly Ser Cys Ala Asp Pro Ser Pro Ser Ala
        35                  40                  45              
Ser Leu Thr Ala Asp Arg Arg Arg Gln Pro Leu Pro Thr Ala Ala Gly
    50                  55                  60                  
Glu Glu Met Thr Pro Pro Ala Gly Leu Ala Glu Glu Leu Pro Pro Gln
65                  70                  75                  80  
Pro Gln Leu Gln Gln Gln Gly Arg Phe Leu Ala Gly Val Ala Trp Asp
                85                  90                  95      
Gly Ala Ala Arg Glu Leu Val Gly Asn Arg Ser Ala Leu Arg Leu Ser
            100                 105                 110         
Arg Arg Gly Pro Gly Leu Gln Gln Pro Ser Pro Ser Val Ala Ala Ala
        115                 120                 125             
Ala Gly Pro Ala Pro Gln Ser Leu Asp Leu His Lys Lys Pro Gln Arg
    130                 135                 140                 
Gly Arg Pro Thr Arg Ala Asp Pro Ala Leu Ala Glu Pro Thr Pro Thr
145                 150                 155                 160 
Ala Ser Pro Gly Ser Ala Pro Ser Pro Ala Gly Asp Pro Trp Gln Arg
                165                 170                 175     
Ala Thr Lys His Arg Leu Gly Thr Glu His Gln Glu Arg Ala Ala Gln
            180                 185                 190         
Ser Asp Gly Gly Ala Gly Leu Pro Pro Leu Val Ser Asp Pro Cys Asp
        195                 200                 205             
Phe Asn Lys Phe Ile Leu Cys Asn Leu Thr Val Glu Ala Val Gly Ala
    210                 215                 220                 
Asp Ser Ala Ser Val Arg Trp Ala Val Arg Glu His Arg Ser Pro Arg
225                 230                 235                 240 
Pro Leu Gly Gly Ala Arg Phe Arg Leu Leu Phe Asp Arg Phe Gly Gln
                245                 250                 255     
Gln Pro Lys Phe His Arg Phe Val Tyr Leu Pro Glu Ser Ser Asp Ser
            260                 265                 270         
Ala Thr Leu Arg Glu Leu Arg Gly Asp Thr Pro Tyr Leu Val Cys Val
        275                 280                 285             
Glu Gly Val Leu Gly Gly Arg Val Cys Pro Val Ala Pro Arg Asp His
    290                 295                 300                 
Cys Ala Gly Leu Val Thr Leu Pro Glu Ala Gly Ser Arg Gly Gly Val
305                 310                 315                 320 
Asp Tyr Gln Leu Leu Thr Leu Ala Leu Leu Thr Val Asn Ala Leu Leu
                325                 330                 335     
Val Leu Leu Ala Leu Ala Ala Trp Ala Ser Arg Trp Leu Arg Arg Lys
            340                 345                 350         
Leu Arg Ala Arg Arg Lys Gly Gly Ala Pro Val His Val Arg His Met
        355                 360                 365             
Tyr Ser Thr Arg Arg Pro Leu Arg Ser Met Gly Thr Gly Val Ser Ala
    370                 375                 380                 
Asp Phe Ser Gly Phe Gln Ser His Arg Pro Arg Thr Thr Val Cys Ala
385                 390                 395                 400 
Leu Ser Glu Ala Asp Leu Ile Glu Phe Pro Cys Asp Arg Phe Met Asp
                405                 410                 415     
Ser Ala Gly Gly Gly Ala Gly Gly Ser Leu Arg Arg Glu Asp Arg Leu
            420                 425                 430         
Leu Gln Arg Phe Ala Asp
        435             


<210> 1621
<211> 326
<212> PRT
<213> Homo sapiens

<400> 1621
Met Ile Thr Arg Lys Val Gly Ala Ala Leu Ala Ala Gly Cys Thr Val
 1               5                  10                  15      
Val Val Lys Pro Ala Glu Asp Thr Pro Phe Ser Ala Leu Ala Leu Ala
            20                  25                  30          
Glu Leu Ala Ser Gln Ala Gly Ile Pro Ser Gly Val Tyr Asn Val Ile
        35                  40                  45              
Pro Cys Ser Arg Lys Asn Ala Lys Glu Val Gly Glu Ala Ile Cys Thr
    50                  55                  60                  
Asp Pro Leu Val Ser Lys Ile Ser Phe Thr Gly Ser Thr Thr Thr Gly
65                  70                  75                  80  
Lys Ile Leu Leu His His Ala Ala Asn Ser Val Lys Arg Val Ser Met
                85                  90                  95      
Glu Leu Gly Gly Leu Ala Pro Phe Ile Val Phe Asp Ser Ala Asn Val
            100                 105                 110         
Asp Gln Ala Val Ala Gly Ala Met Ala Ser Lys Phe Arg Asn Thr Gly
        115                 120                 125             
Gln Thr Cys Val Cys Ser Asn Gln Phe Leu Val Gln Arg Gly Ile His
    130                 135                 140                 
Asp Ala Phe Val Lys Ala Phe Ala Glu Ala Met Lys Lys Asn Leu Arg
145                 150                 155                 160 
Val Gly Asn Gly Phe Glu Glu Gly Thr Thr Gln Gly Pro Leu Ile Asn
                165                 170                 175     
Glu Lys Ala Val Glu Lys Val Glu Lys Gln Val Asn Asp Ala Val Ser
            180                 185                 190         
Lys Gly Ala Thr Val Val Thr Gly Gly Lys Arg His Gln Leu Gly Lys
        195                 200                 205             
Asn Phe Phe Glu Pro Thr Leu Leu Cys Asn Val Thr Gln Asp Met Leu
    210                 215                 220                 
Cys Thr His Glu Glu Thr Phe Gly Pro Leu Ala Pro Val Ile Lys Phe
225                 230                 235                 240 
Asp Thr Glu Glu Glu Ala Ile Ala Ile Ala Asn Ala Ala Asp Val Gly
                245                 250                 255     
Leu Ala Gly Tyr Phe Tyr Ser Gln Asp Pro Ala Gln Ile Trp Arg Val
            260                 265                 270         
Ala Glu Gln Leu Glu Val Gly Met Val Gly Val Asn Glu Gly Leu Ile
        275                 280                 285             
Ser Ser Val Glu Cys Pro Phe Gly Gly Val Lys Gln Ser Gly Leu Gly
    290                 295                 300                 
Arg Glu Gly Ser Lys Tyr Gly Ile Asp Glu Tyr Leu Glu Leu Lys Tyr
305                 310                 315                 320 
Val Cys Tyr Gly Gly Leu
                325     


<210> 1622
<211> 1072
<212> PRT
<213> Homo sapiens

<400> 1622
Met Ala Pro Pro Thr Gly Val Leu Ser Ser Leu Leu Leu Leu Val Thr
 1               5                  10                  15      
Ile Ala Gly Cys Ala Arg Lys Gln Cys Ser Glu Gly Arg Thr Tyr Ser
            20                  25                  30          
Asn Ala Val Ile Ser Pro Asn Leu Glu Thr Thr Arg Ile Met Arg Val
        35                  40                  45              
Ser His Thr Phe Pro Val Val Asp Cys Thr Ala Ala Cys Cys Asp Leu
    50                  55                  60                  
Ser Ser Cys Asp Leu Ala Trp Trp Phe Glu Gly Arg Cys Tyr Leu Val
65                  70                  75                  80  
Ser Cys Pro His Lys Glu Asn Cys Glu Pro Lys Lys Met Gly Pro Ile
                85                  90                  95      
Arg Ser Tyr Leu Thr Phe Val Leu Arg Pro Val Gln Arg Pro Ala Gln
            100                 105                 110         
Leu Leu Asp Tyr Gly Asp Met Met Leu Asn Arg Gly Ser Pro Ser Gly
        115                 120                 125             
Ile Trp Gly Asp Ser Pro Glu Asp Ile Arg Lys Asp Leu Thr Phe Leu
    130                 135                 140                 
Gly Lys Asp Trp Gly Leu Glu Glu Met Ser Glu Tyr Ser Asp Asp Tyr
145                 150                 155                 160 
Arg Glu Leu Glu Lys Asp Leu Leu Gln Pro Ser Gly Lys Gln Glu Pro
                165                 170                 175     
Arg Gly Ser Ala Glu Tyr Thr Asp Trp Gly Leu Leu Pro Gly Ser Glu
            180                 185                 190         
Gly Ala Phe Asn Ser Ser Val Gly Asp Ser Pro Ala Val Pro Ala Glu
        195                 200                 205             
Thr Gln Gln Asp Pro Glu Leu His Tyr Leu Asn Glu Ser Ala Ser Thr
    210                 215                 220                 
Pro Ala Pro Lys Leu Pro Glu Arg Ser Val Leu Leu Pro Leu Pro Thr
225                 230                 235                 240 
Thr Pro Ser Ser Gly Glu Val Leu Glu Lys Glu Lys Ala Ser Gln Leu
                245                 250                 255     
Gln Glu Gln Ser Ser Asn Ser Ser Gly Lys Glu Val Leu Met Pro Ser
            260                 265                 270         
His Ser Leu Pro Pro Ala Ser Leu Glu Leu Ser Ser Val Thr Val Glu
        275                 280                 285             
Lys Ser Pro Val Leu Thr Val Thr Pro Gly Ser Thr Glu His Ser Ile
    290                 295                 300                 
Pro Thr Pro Pro Thr Ser Ala Ala Pro Ser Glu Ser Thr Pro Ser Glu
305                 310                 315                 320 
Leu Pro Ile Ser Pro Thr Thr Ala Pro Arg Thr Val Lys Glu Leu Thr
                325                 330                 335     
Val Ser Ala Gly Asp Asn Leu Ile Ile Thr Leu Pro Asp Asn Glu Val
            340                 345                 350         
Glu Leu Lys Ala Phe Val Ala Pro Ala Pro Pro Val Glu Thr Thr Tyr
        355                 360                 365             
Asn Tyr Glu Trp Asn Leu Ile Ser His Pro Thr Asp Tyr Gln Gly Glu
    370                 375                 380                 
Ile Lys Gln Gly His Lys Gln Thr Leu Asn Leu Ser Gln Leu Ser Val
385                 390                 395                 400 
Gly Leu Tyr Val Phe Lys Val Thr Val Ser Ser Glu Asn Ala Phe Gly
                405                 410                 415     
Glu Gly Phe Val Asn Val Thr Val Lys Pro Ala Arg Arg Val Asn Leu
            420                 425                 430         
Pro Pro Val Ala Val Val Ser Pro Gln Leu Gln Glu Leu Thr Leu Pro
        435                 440                 445             
Leu Thr Ser Ala Leu Ile Asp Gly Ser Gln Ser Thr Asp Asp Thr Glu
    450                 455                 460                 
Ile Val Ser Tyr His Trp Glu Glu Ile Asn Gly Pro Phe Ile Glu Glu
465                 470                 475                 480 
Lys Thr Ser Val Asp Ser Pro Val Leu Arg Leu Ser Asn Leu Asp Pro
                485                 490                 495     
Gly Asn Tyr Ser Phe Arg Leu Thr Val Thr Asp Ser Asp Gly Ala Thr
            500                 505                 510         
Asn Ser Thr Thr Ala Ala Leu Ile Val Asn Asn Ala Val Asp Tyr Pro
        515                 520                 525             
Pro Val Ala Asn Ala Gly Pro Asn His Thr Ile Thr Leu Pro Gln Asn
    530                 535                 540                 
Ser Ile Thr Leu Asn Gly Asn Gln Ser Ser Asp Asp His Gln Ile Val
545                 550                 555                 560 
Leu Tyr Glu Trp Ser Leu Gly Pro Gly Ser Glu Gly Lys His Val Val
                565                 570                 575     
Met Gln Gly Val Gln Thr Pro Tyr Leu His Leu Ser Ala Met Gln Glu
            580                 585                 590         
Gly Asp Tyr Thr Phe Gln Leu Lys Val Thr Asp Ser Ser Arg Gln Gln
        595                 600                 605             
Ser Thr Ala Val Val Thr Val Ile Val Gln Pro Glu Asn Asn Arg Pro
    610                 615                 620                 
Pro Val Ala Val Ala Gly Pro Asp Lys Glu Leu Ile Phe Pro Val Glu
625                 630                 635                 640 
Ser Ala Thr Leu Asp Gly Ser Ser Ser Ser Asp Asp His Gly Ile Val
                645                 650                 655     
Phe Tyr His Trp Glu His Val Arg Gly Pro Ser Ala Val Glu Met Glu
            660                 665                 670         
Asn Ile Asp Lys Ala Ile Ala Thr Val Thr Gly Leu Gln Val Gly Thr
        675                 680                 685             
Tyr His Phe Arg Leu Thr Val Lys Asp Gln Gln Gly Leu Ser Ser Thr
    690                 695                 700                 
Ser Thr Leu Thr Val Ala Val Lys Lys Glu Asn Asn Ser Pro Pro Arg
705                 710                 715                 720 
Ala Arg Ala Gly Gly Arg His Val Leu Val Leu Pro Asn Asn Ser Ile
                725                 730                 735     
Thr Leu Asp Gly Ser Arg Ser Thr Asp Asp Gln Arg Ile Val Ser Tyr
            740                 745                 750         
Leu Trp Ile Arg Asp Gly Gln Ser Pro Ala Ala Gly Asp Val Ile Asp
        755                 760                 765             
Gly Ser Asp His Ser Val Ala Leu Gln Leu Thr Asn Leu Val Glu Gly
    770                 775                 780                 
Val Tyr Thr Phe His Leu Arg Val Thr Asp Ser Gln Gly Ala Ser Asp
785                 790                 795                 800 
Thr Asp Thr Ala Thr Val Glu Val Gln Pro Asp Pro Arg Lys Ser Gly
                805                 810                 815     
Leu Val Glu Leu Thr Leu Gln Val Gly Val Gly Gln Leu Thr Glu Gln
            820                 825                 830         
Arg Lys Asp Thr Leu Val Arg Gln Leu Ala Val Leu Leu Asn Val Leu
        835                 840                 845             
Asp Ser Asp Ile Lys Val Gln Lys Ile Arg Ala His Ser Asp Leu Ser
    850                 855                 860                 
Thr Val Ile Val Phe Tyr Val Gln Ser Arg Pro Pro Phe Lys Val Leu
865                 870                 875                 880 
Lys Ala Ala Glu Val Ala Arg Asn Leu His Met Arg Leu Ser Lys Glu
                885                 890                 895     
Lys Ala Asp Phe Leu Leu Phe Lys Val Leu Arg Val Asp Thr Ala Gly
            900                 905                 910         
Cys Leu Leu Lys Cys Ser Gly His Gly His Cys Asp Pro Leu Thr Lys
        915                 920                 925             
Arg Cys Ile Cys Ser His Leu Trp Met Glu Asn Leu Ile Gln Arg Tyr
    930                 935                 940                 
Ile Trp Asp Gly Glu Ser Asn Cys Glu Trp Ser Ile Phe Tyr Val Thr
945                 950                 955                 960 
Val Leu Ala Phe Thr Leu Ile Val Leu Thr Gly Gly Phe Thr Trp Leu
                965                 970                 975     
Cys Ile Cys Cys Cys Lys Arg Gln Lys Arg Thr Lys Ile Arg Lys Lys
            980                 985                 990         
Thr Lys Tyr Thr Ile Leu Asp Asn Met Asp Glu Gln Glu Arg Met Glu
        995                 1000                1005            
Leu Arg Pro Lys Tyr Gly Ile Lys His Arg Ser Thr Glu His Asn Ser
    1010                1015                1020                
Ser Leu Met Val Ser Glu Ser Glu Phe Asp Ser Asp Gln Asp Thr Ile
1025                1030                1035                1040
Phe Ser Arg Glu Lys Met Glu Arg Gly Asn Pro Lys Val Ser Met Asn
                1045                1050                1055    
Gly Ser Ile Arg Asn Gly Ala Ser Phe Ser Tyr Cys Ser Lys Asp Arg
            1060                1065                1070        


<210> 1623
<211> 418
<212> PRT
<213> Homo sapiens

<400> 1623
Met Ser Ile Glu Ile Pro Ala Gly Leu Thr Glu Leu Leu Gln Gly Phe
 1               5                  10                  15      
Thr Val Glu Val Leu Arg His Gln Pro Ala Asp Leu Leu Glu Phe Ala
            20                  25                  30          
Leu Gln His Phe Thr Arg Leu Gln Gln Glu Asn Glu Arg Lys Gly Thr
        35                  40                  45              
Ala Arg Phe Gly His Glu Gly Arg Thr Trp Gly Asp Leu Gly Ala Ala
    50                  55                  60                  
Ala Gly Gly Gly Thr Pro Ser Lys Gly Val Asn Phe Ala Glu Glu Pro
65                  70                  75                  80  
Met Gln Ser Asp Ser Glu Asp Gly Glu Glu Glu Glu Ala Ala Pro Ala
                85                  90                  95      
Asp Ala Gly Ala Phe Asn Ala Pro Val Ile Asn Arg Phe Thr Arg Arg
            100                 105                 110         
Ala Ser Val Cys Ala Glu Ala Tyr Asn Pro Asp Glu Glu Glu Asp Asp
        115                 120                 125             
Ala Glu Ser Arg Ile Ile His Pro Lys Thr Asp Asp Gln Arg Asn Arg
    130                 135                 140                 
Leu Gln Glu Ala Cys Lys Asp Ile Leu Leu Phe Lys Asn Leu Asp Pro
145                 150                 155                 160 
Glu Gln Met Ser Gln Val Leu Asp Ala Met Phe Glu Lys Leu Val Lys
                165                 170                 175     
Asp Gly Glu His Val Ile Asp Gln Gly Asp Asp Gly Asp Asn Phe Tyr
            180                 185                 190         
Val Ile Asp Arg Gly Thr Phe Asp Ile Tyr Val Lys Cys Asp Gly Val
        195                 200                 205             
Gly Arg Cys Val Gly Asn Tyr Asp Asn Arg Gly Ser Phe Gly Glu Leu
    210                 215                 220                 
Ala Leu Met Tyr Asn Thr Pro Arg Ala Ala Thr Ile Thr Ala Thr Ser
225                 230                 235                 240 
Pro Gly Ala Leu Trp Gly Leu Asp Arg Val Thr Phe Arg Arg Ile Ile
                245                 250                 255     
Val Lys Asn Asn Ala Lys Lys Arg Lys Met Tyr Glu Ser Phe Ile Glu
            260                 265                 270         
Ser Leu Pro Phe Leu Lys Ser Leu Glu Phe Ser Glu Arg Leu Lys Val
        275                 280                 285             
Val Asp Val Ile Gly Thr Lys Val Tyr Asn Asp Gly Glu Gln Ile Ile
    290                 295                 300                 
Ala Gln Gly Asp Ser Ala Asp Ser Phe Phe Ile Val Glu Ser Gly Glu
305                 310                 315                 320 
Val Lys Ile Thr Met Lys Arg Lys Gly Lys Ser Glu Val Glu Glu Asn
                325                 330                 335     
Gly Ala Val Glu Ile Ala Arg Cys Ser Arg Gly Gln Tyr Phe Gly Glu
            340                 345                 350         
Leu Ala Leu Val Thr Asn Lys Pro Arg Ala Ala Ser Ala His Ala Ile
        355                 360                 365             
Gly Thr Val Lys Cys Leu Ala Met Asp Val Gln Ala Phe Glu Arg Leu
    370                 375                 380                 
Leu Gly Pro Cys Met Glu Ile Met Lys Arg Asn Ile Ala Thr Tyr Glu
385                 390                 395                 400 
Glu Gln Leu Val Ala Leu Phe Gly Thr Asn Met Asp Ile Val Glu Pro
                405                 410                 415     
Thr Ala
        


<210> 1624
<211> 3427
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124,
125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136,
137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148,
149, 150, 151, 152, 153, 154, 155, 156, 157, 158
<223> Xaa = Any Amino Acid

<400> 1624
Met Glu Arg Ser Gly Trp Ala Arg Gln Thr Phe Leu Leu Ala Leu Leu
 1               5                  10                  15      
Leu Gly Ala Thr Leu Arg Ala Arg Ala Ala Ala Gly Tyr Tyr Pro Arg
            20                  25                  30          
Phe Ser Pro Phe Phe Phe Leu Cys Thr His His Gly Glu Leu Glu Gly
        35                  40                  45              
Asp Gly Glu Gln Gly Glu Val Leu Ile Ser Leu His Ile Ala Gly Asn
    50                  55                  60                  
Pro Thr Tyr Tyr Val Pro Gly Gln Glu Tyr His Val Thr Ile Ser Thr
65                  70                  75                  80  
Ser Thr Phe Phe Asp Gly Leu Leu Val Thr Gly Leu Tyr Thr Ser Thr
                85                  90                  95      
Ser Val Gln Ala Ser Gln Ser Ile Gly Gly Ser Ser Ala Phe Gly Phe
            100                 105                 110         
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
        115                 120                 125             
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    130                 135                 140                 
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Thr
145                 150                 155                 160 
Ala Thr His Arg Gly Gln Val Ile Phe Lys Asp Ala Leu Ala Gln Gln
                165                 170                 175     
Leu Cys Glu Gln Gly Ala Pro Thr Asp Val Thr Val His Pro His Leu
            180                 185                 190         
Ala Glu Ile His Ser Asp Ser Ile Ile Leu Arg Asp Asp Phe Asp Ser
        195                 200                 205             
Tyr His Gln Leu Gln Leu Asn Pro Asn Ile Trp Val Glu Cys Asn Asn
    210                 215                 220                 
Cys Glu Thr Gly Glu Gln Cys Gly Ala Ile Met His Gly Asn Ala Val
225                 230                 235                 240 
Thr Phe Cys Glu Pro Tyr Gly Pro Arg Glu Leu Ile Thr Thr Gly Leu
                245                 250                 255     
Asn Thr Thr Thr Ala Ser Val Leu Gln Phe Ser Ile Gly Ser Gly Ser
            260                 265                 270         
Cys Arg Phe Ser Tyr Ser Asp Pro Ser Ile Ile Val Leu Tyr Ala Lys
        275                 280                 285             
Asn Asn Ser Ala Asp Trp Ile Gln Leu Glu Lys Ile Arg Ala Pro Ser
    290                 295                 300                 
Asn Val Ser Thr Ile Ile His Ile Leu Tyr Leu Pro Glu Asp Ala Lys
305                 310                 315                 320 
Gly Glu Asn Val Gln Phe Gln Trp Lys Gln Glu Asn Leu Arg Val Gly
                325                 330                 335     
Glu Val Tyr Glu Ala Cys Trp Ala Leu Asp Asn Ile Leu Ile Ile Asn
            340                 345                 350         
Ser Ala His Arg Gln Val Val Leu Glu Asp Ser Leu Asp Pro Val Asp
        355                 360                 365             
Thr Gly Asn Trp Leu Phe Phe Pro Gly Ala Thr Val Lys His Ser Cys
    370                 375                 380                 
Gln Ser Asp Gly Asn Ser Ile Tyr Phe His Gly Asn Glu Gly Ser Glu
385                 390                 395                 400 
Phe Asn Phe Ala Thr Thr Arg Asp Val Asp Leu Ser Thr Glu Asp Ile
                405                 410                 415     
Gln Glu Gln Trp Ser Glu Glu Phe Glu Ser Gln Pro Thr Gly Trp Asp
            420                 425                 430         
Val Leu Gly Ala Val Ile Gly Thr Glu Cys Gly Thr Ile Glu Ser Gly
        435                 440                 445             
Leu Ser Met Val Phe Leu Lys Asp Gly Glu Arg Lys Leu Cys Thr Pro
    450                 455                 460                 
Ser Met Asp Thr Thr Gly Tyr Gly Asn Leu Arg Phe Tyr Phe Val Met
465                 470                 475                 480 
Gly Gly Ile Cys Asp Pro Gly Asn Ser His Glu Asn Asp Ile Ile Leu
                485                 490                 495     
Tyr Ala Lys Ile Glu Gly Arg Lys Glu His Ile Thr Leu Asp Thr Leu
            500                 505                 510         
Ser Tyr Ser Ser Tyr Lys Val Pro Ser Leu Val Ser Val Val Ile Asn
        515                 520                 525             
Pro Glu Leu Gln Thr Pro Ala Thr Lys Phe Cys Leu Arg Gln Lys Asn
    530                 535                 540                 
His Gln Gly His Asn Arg Asn Val Trp Ala Val Asp Phe Phe His Val
545                 550                 555                 560 
Leu Pro Val Leu Pro Ser Thr Met Ser His Met Ile Gln Phe Ser Ile
                565                 570                 575     
Asn Leu Gly Cys Gly Thr His Gln Pro Gly Asn Ser Val Ser Leu Glu
            580                 585                 590         
Phe Ser Thr Asn His Gly Arg Ser Trp Ser Leu Leu His Thr Glu Cys
        595                 600                 605             
Leu Pro Glu Ile Cys Ala Gly Pro His Leu Pro His Ser Thr Val Tyr
    610                 615                 620                 
Ser Ser Glu Asn Tyr Ser Gly Trp Asn Arg Ile Thr Ile Pro Leu Pro
625                 630                 635                 640 
Asn Ala Ala Leu Thr Arg Asn Thr Arg Ile Arg Trp Arg Gln Thr Gly
                645                 650                 655     
Pro Ile Leu Gly Asn Met Trp Ala Ile Asp Asn Val Tyr Ile Gly Pro
            660                 665                 670         
Ser Cys Leu Lys Phe Cys Ser Gly Arg Gly Gln Cys Thr Arg His Gly
        675                 680                 685             
Cys Lys Cys Asp Pro Gly Phe Ser Gly Pro Ala Cys Glu Met Ala Ser
    690                 695                 700                 
Gln Thr Phe Pro Met Phe Ile Ser Glu Ser Phe Gly Ser Ser Arg Leu
705                 710                 715                 720 
Ser Ser Tyr His Asn Phe Tyr Ser Ile Arg Gly Ala Glu Val Ser Phe
                725                 730                 735     
Gly Cys Gly Val Leu Ala Ser Gly Lys Ala Leu Val Phe Asn Lys Asp
            740                 745                 750         
Gly Arg Arg Gln Leu Ile Thr Ser Phe Leu Asp Ser Ser Gln Ser Arg
        755                 760                 765             
Phe Leu Gln Phe Thr Leu Arg Leu Gly Ser Lys Ser Val Leu Ser Thr
    770                 775                 780                 
Cys Arg Ala Pro Asp Gln Pro Gly Glu Gly Val Leu Leu His Tyr Ser
785                 790                 795                 800 
Tyr Asp Asn Gly Ile Thr Trp Lys Leu Leu Glu His Tyr Ser Tyr Leu
                805                 810                 815     
Ser Tyr His Glu Pro Arg Ile Ile Ser Val Glu Leu Pro Gly Asp Ala
            820                 825                 830         
Lys Gln Phe Gly Ile Gln Phe Arg Trp Trp Gln Pro Tyr His Ser Ser
        835                 840                 845             
Gln Arg Glu Asp Val Trp Ala Ile Asp Glu Ile Ile Met Thr Ser Val
    850                 855                 860                 
Leu Phe Asn Ser Ile Ser Leu Asp Phe Thr Asn Leu Val Glu Val Thr
865                 870                 875                 880 
Gln Ser Leu Gly Phe Tyr Leu Gly Asn Val Gln Pro Tyr Cys Gly His
                885                 890                 895     
Asp Trp Thr Leu Cys Phe Thr Gly Asp Ser Lys Leu Ala Ser Ser Met
            900                 905                 910         
Arg Tyr Val Glu Thr Gln Ser Met Gln Ile Gly Ala Ser Tyr Met Ile
        915                 920                 925             
Gln Phe Ser Leu Val Met Gly Cys Gly Gln Lys Tyr Thr Pro His Met
    930                 935                 940                 
Asp Asn Gln Val Lys Leu Glu Tyr Ser Thr Asn His Gly Leu Thr Trp
945                 950                 955                 960 
His Leu Val Gln Glu Glu Cys Leu Pro Ser Met Pro Ser Cys Gln Glu
                965                 970                 975     
Phe Thr Ser Ala Ser Ile Tyr His Ala Ser Glu Phe Thr Gln Trp Arg
            980                 985                 990         
Arg Val Ile Val Leu Leu Pro Gln Lys Thr Trp Ser Ser Ala Thr Arg
        995                 1000                1005            
Phe Arg Trp Ser Gln Ser Tyr Tyr Thr Ala Gln Asp Glu Trp Ala Leu
    1010                1015                1020                
Asp Ser Ile Tyr Ile Gly Gln Gln Cys Pro Asn Met Cys Ser Gly His
1025                1030                1035                1040
Gly Ser Cys Asp His Gly Ile Cys Arg Cys Asp Gln Gly Tyr Gln Gly
                1045                1050                1055    
Thr Glu Cys His Pro Glu Ala Ala Leu Pro Ser Thr Ile Met Ser Asp
            1060                1065                1070        
Phe Glu Asn Gln Asn Gly Trp Glu Ser Asp Trp Gln Glu Val Ile Gly
        1075                1080                1085            
Gly Glu Ile Val Lys Pro Glu Gln Gly Cys Gly Val Ile Ser Ser Gly
    1090                1095                1100                
Ser Ser Leu Tyr Phe Ser Lys Ala Gly Lys Arg Gln Leu Val Ser Trp
1105                1110                1115                1120
Asp Leu Asp Thr Ser Trp Val Asp Phe Val Gln Phe Tyr Ile Gln Ile
                1125                1130                1135    
Gly Gly Glu Ser Ala Ser Cys Asn Lys Pro Asp Ser Arg Glu Glu Gly
            1140                1145                1150        
Val Leu Leu Gln Tyr Ser Asn Asn Gly Gly Ile Gln Trp His Leu Leu
        1155                1160                1165            
Ala Glu Met Tyr Phe Ser Asp Phe Ser Lys Pro Arg Phe Val Tyr Leu
    1170                1175                1180                
Glu Leu Pro Ala Ala Ala Lys Thr Pro Cys Thr Arg Phe Arg Trp Trp
1185                1190                1195                1200
Gln Pro Val Phe Ser Gly Glu Asp Tyr Asp Gln Trp Ala Val Asp Asp
                1205                1210                1215    
Ile Ile Ile Leu Ser Glu Lys Gln Lys Gln Ile Ile Pro Val Ile Asn
            1220                1225                1230        
Pro Thr Leu Pro Gln Asn Phe Tyr Glu Lys Pro Ala Phe Asp Tyr Pro
        1235                1240                1245            
Met Asn Gln Met Ser Val Trp Leu Met Leu Ala Asn Glu Gly Met Val
    1250                1255                1260                
Lys Asn Glu Thr Phe Cys Ala Ala Thr Pro Ser Ala Met Ile Phe Gly
1265                1270                1275                1280
Lys Ser Asp Gly Asp Arg Phe Ala Val Thr Arg Asp Leu Thr Leu Lys
                1285                1290                1295    
Pro Gly Tyr Val Leu Gln Phe Lys Leu Asn Ile Gly Cys Ala Asn Gln
            1300                1305                1310        
Phe Ser Ser Thr Ala Pro Val Leu Leu Gln Tyr Ser His Asp Ala Gly
        1315                1320                1325            
Met Ser Trp Phe Leu Val Lys Glu Gly Cys Tyr Pro Ala Ser Ala Gly
    1330                1335                1340                
Lys Gly Cys Glu Gly Asn Ser Arg Glu Leu Ser Glu Pro Thr Met Tyr
1345                1350                1355                1360
His Thr Gly Asp Phe Glu Glu Trp Thr Arg Ile Thr Ile Val Ile Pro
                1365                1370                1375    
Arg Ser Leu Ala Ser Ser Lys Thr Arg Phe Arg Trp Ile Gln Glu Ser
            1380                1385                1390        
Ser Ser Gln Lys Asn Val Pro Pro Phe Gly Leu Asp Gly Val Tyr Ile
        1395                1400                1405            
Ser Glu Pro Cys Pro Ser Tyr Cys Ser Gly His Gly Asp Cys Ile Ser
    1410                1415                1420                
Gly Val Cys Phe Cys Asp Leu Gly Tyr Thr Ala Ala Gln Gly Thr Cys
1425                1430                1435                1440
Val Ser Asn Val Pro Asn His Asn Glu Met Phe Asp Arg Phe Glu Gly
                1445                1450                1455    
Lys Leu Ser Pro Leu Trp Tyr Lys Ile Thr Gly Ala Gln Val Gly Thr
            1460                1465                1470        
Gly Cys Gly Thr Leu Asn Asp Gly Lys Ser Leu Tyr Phe Asn Gly Pro
        1475                1480                1485            
Gly Lys Arg Glu Ala Arg Thr Val Pro Leu Asp Thr Arg Asn Ile Arg
    1490                1495                1500                
Leu Val Gln Phe Tyr Ile Gln Ile Gly Ser Lys Thr Ser Gly Ile Thr
1505                1510                1515                1520
Cys Ile Lys Pro Arg Thr Arg Asn Glu Gly Leu Ile Val Gln Tyr Ser
                1525                1530                1535    
Asn Asp Asn Gly Ile Leu Trp His Leu Leu Arg Glu Leu Asp Phe Met
            1540                1545                1550        
Ser Phe Leu Glu Pro Gln Ile Ile Ser Ile Asp Leu Pro Gln Asp Ala
        1555                1560                1565            
Lys Thr Pro Ala Thr Ala Phe Arg Trp Trp Gln Pro Gln His Gly Lys
    1570                1575                1580                
His Ser Ala Gln Trp Ala Leu Asp Asp Val Leu Ile Gly Met Asn Asp
1585                1590                1595                1600
Ser Ser Gln Thr Gly Phe Gln Asp Lys Phe Asp Gly Ser Ile Asp Leu
                1605                1610                1615    
Gln Ala Asn Trp Tyr Arg Ile Gln Gly Gly Gln Val Asp Ile Asp Cys
            1620                1625                1630        
Leu Ser Met Asp Thr Ala Leu Ile Phe Thr Glu Asn Ile Gly Lys Pro
        1635                1640                1645            
Arg Tyr Ala Glu Thr Trp Asp Phe His Val Ser Ala Ser Thr Phe Leu
    1650                1655                1660                
Gln Phe Glu Met Ser Met Gly Cys Ser Lys Pro Phe Ser Asn Ser His
1665                1670                1675                1680
Ser Val Gln Leu Gln Tyr Ser Leu Asn Asn Gly Lys Asp Trp His Leu
                1685                1690                1695    
Val Thr Glu Glu Cys Val Pro Pro Thr Ile Gly Cys Leu His Tyr Thr
            1700                1705                1710        
Glu Ser Ser Ile Tyr Thr Ser Glu Arg Phe Gln Asn Trp Lys Arg Ile
        1715                1720                1725            
Thr Val Tyr Leu Pro Leu Ser Thr Ile Ser Pro Arg Thr Arg Phe Arg
    1730                1735                1740                
Trp Ile Gln Ala Asn Tyr Thr Val Gly Ala Asp Ser Trp Ala Ile Asp
1745                1750                1755                1760
Asn Val Val Leu Ala Ser Gly Cys Pro Trp Met Cys Ser Gly Arg Gly
                1765                1770                1775    
Ile Cys Asp Ala Gly Arg Cys Val Cys Asp Arg Gly Phe Gly Gly Pro
            1780                1785                1790        
Tyr Cys Val Pro Val Val Pro Leu Pro Ser Ile Leu Lys Asp Asp Phe
        1795                1800                1805            
Asn Gly Asn Leu His Pro Asp Leu Trp Pro Glu Val Tyr Gly Ala Glu
    1810                1815                1820                
Arg Gly Asn Leu Asn Gly Glu Thr Ile Lys Ser Gly Thr Ser Leu Ile
1825                1830                1835                1840
Phe Lys Gly Glu Gly Leu Arg Met Leu Ile Ser Arg Asp Leu Asp Cys
                1845                1850                1855    
Thr Asn Thr Met Tyr Val Gln Phe Ser Leu Arg Phe Ile Ala Lys Ser
            1860                1865                1870        
Thr Pro Glu Arg Ser His Ser Ile Leu Leu Gln Phe Ser Ile Ser Gly
        1875                1880                1885            
Gly Ile Thr Trp His Leu Met Asp Glu Phe Tyr Phe Pro Gln Thr Thr
    1890                1895                1900                
Asn Ile Leu Phe Ile Asn Val Pro Leu Pro Tyr Thr Ala Gln Thr Asn
1905                1910                1915                1920
Ala Thr Arg Phe Arg Leu Trp Gln Pro Tyr Asn Asn Gly Lys Lys Glu
                1925                1930                1935    
Glu Ile Trp Ile Val Asp Asp Phe Ile Ile Asp Gly Asn Asn Val Asn
            1940                1945                1950        
Asn Pro Val Met Leu Leu Asp Thr Phe Asp Phe Gly Pro Arg Glu Asp
        1955                1960                1965            
Asn Trp Phe Phe Tyr Pro Gly Gly Asn Ile Gly Leu Tyr Cys Pro Tyr
    1970                1975                1980                
Ser Ser Lys Gly Ala Pro Glu Glu Asp Ser Ala Met Val Phe Val Ser
1985                1990                1995                2000
Asn Glu Val Gly Glu His Ser Ile Thr Thr Arg Asp Leu Asn Val Asn
                2005                2010                2015    
Glu Asn Thr Ile Ile Gln Phe Glu Ile Asn Val Gly Cys Ser Thr Asp
            2020                2025                2030        
Ser Ser Ser Ala Asp Pro Val Arg Leu Glu Phe Ser Arg Asp Phe Gly
        2035                2040                2045            
Ala Thr Trp His Leu Leu Leu Pro Leu Cys Tyr His Ser Ser Ser His
    2050                2055                2060                
Val Ser Ser Leu Cys Ser Thr Glu His His Pro Ser Ser Thr Tyr Tyr
2065                2070                2075                2080
Ala Gly Thr Met Gln Gly Trp Arg Arg Glu Val Val His Phe Gly Lys
                2085                2090                2095    
Leu His Leu Cys Gly Ser Val Arg Phe Arg Trp Tyr Gln Gly Phe Tyr
            2100                2105                2110        
Pro Ala Gly Ser Gln Pro Val Thr Trp Ala Ile Asp Asn Val Tyr Ile
        2115                2120                2125            
Gly Pro Gln Cys Glu Glu Met Cys Asn Gly Gln Gly Ser Cys Ile Asn
    2130                2135                2140                
Gly Thr Lys Cys Ile Cys Asp Pro Gly Tyr Ser Gly Pro Thr Cys Lys
2145                2150                2155                2160
Ile Ser Thr Lys Asn Pro Asp Phe Leu Lys Asp Asp Phe Glu Gly Gln
                2165                2170                2175    
Leu Glu Ser Asp Arg Phe Leu Leu Met Ser Gly Gly Lys Pro Ser Arg
            2180                2185                2190        
Lys Cys Gly Ile Leu Ser Ser Gly Asn Asn Leu Phe Phe Asn Glu Asp
        2195                2200                2205            
Gly Leu Arg Met Leu Met Thr Arg Asp Leu Asp Leu Ser His Ala Arg
    2210                2215                2220                
Phe Val Gln Phe Phe Met Arg Leu Gly Cys Gly Lys Gly Val Pro Asp
2225                2230                2235                2240
Pro Arg Ser Gln Pro Val Leu Leu Gln Tyr Ser Leu Asn Gly Gly Leu
                2245                2250                2255    
Ser Trp Ser Leu Leu Gln Glu Phe Leu Phe Ser Asn Ser Ser Asn Val
            2260                2265                2270        
Gly Arg Tyr Ile Ala Leu Glu Ile Pro Leu Lys Ala Arg Ser Gly Ser
        2275                2280                2285            
Thr Arg Leu Arg Trp Trp Gln Pro Ser Glu Asn Gly His Phe Tyr Ser
    2290                2295                2300                
Pro Trp Val Ile Asp Gln Ile Leu Ile Gly Gly Asn Ile Ser Gly Asn
2305                2310                2315                2320
Thr Val Leu Glu Asp Asp Phe Thr Thr Leu Asp Ser Arg Lys Trp Leu
                2325                2330                2335    
Leu His Pro Gly Gly Thr Lys Met Pro Val Cys Gly Ser Thr Gly Asp
            2340                2345                2350        
Ala Leu Val Phe Ile Glu Lys Ala Ser Thr Arg Tyr Val Val Ser Thr
        2355                2360                2365            
Asp Val Ala Val Asn Glu Asp Ser Phe Leu Gln Ile Asp Phe Ala Ala
    2370                2375                2380                
Ser Cys Ser Val Thr Asp Ser Cys Tyr Ala Ile Glu Leu Glu Tyr Ser
2385                2390                2395                2400
Val Asp Leu Gly Leu Ser Trp His Pro Leu Val Arg Asp Cys Leu Pro
                2405                2410                2415    
Thr Asn Val Glu Cys Ser Arg Tyr His Leu Gln Arg Ile Leu Val Ser
            2420                2425                2430        
Asp Thr Phe Asn Lys Trp Thr Arg Ile Thr Leu Pro Leu Pro Pro Tyr
        2435                2440                2445            
Thr Arg Ser Gln Ala Thr Arg Phe Arg Trp His Gln Pro Ala Pro Phe
    2450                2455                2460                
Asp Lys Gln Gln Thr Trp Ala Ile Asp Asn Val Tyr Ile Gly Asp Gly
2465                2470                2475                2480
Cys Ile Asp Met Cys Ser Gly His Gly Arg Cys Ile Gln Gly Asn Cys
                2485                2490                2495    
Val Cys Asp Glu Gln Trp Gly Gly Leu Tyr Cys Asp Asp Pro Glu Thr
            2500                2505                2510        
Ser Leu Pro Thr Gln Leu Lys Asp Asn Phe Asn Arg Ala Pro Ser Ser
        2515                2520                2525            
Gln Asn Trp Leu Thr Val Asn Gly Gly Lys Leu Ser Thr Val Cys Gly
    2530                2535                2540                
Ala Val Ala Ser Gly Met Ala Leu His Phe Ser Gly Gly Cys Ser Arg
2545                2550                2555                2560
Leu Leu Val Thr Val Asp Leu Asn Leu Thr Asn Ala Glu Phe Ile Gln
                2565                2570                2575    
Phe Tyr Phe Met Tyr Gly Cys Leu Ile Thr Pro Asn Asn Arg Asn Gln
            2580                2585                2590        
Gly Val Leu Leu Glu Tyr Ser Val Asn Gly Gly Ile Thr Trp Asn Leu
        2595                2600                2605            
Leu Met Glu Ile Phe Tyr Asp Gln Tyr Ser Lys Pro Gly Phe Val Asn
    2610                2615                2620                
Ile Leu Leu Pro Pro Asp Ala Lys Glu Ile Ala Thr Arg Phe Arg Trp
2625                2630                2635                2640
Trp Gln Pro Arg His Asp Gly Leu Asp Gln Asn Asp Trp Ala Ile Asp
                2645                2650                2655    
Asn Val Leu Ile Ser Gly Ser Ala Asp Gln Arg Thr Val Met Leu Asp
            2660                2665                2670        
Thr Phe Ser Ser Ala Pro Val Pro Gln His Glu Arg Ser Pro Ala Asp
        2675                2680                2685            
Ala Gly Pro Val Gly Arg Ile Ala Phe Asp Met Phe Met Glu Asp Lys
    2690                2695                2700                
Thr Ser Val Asn Glu His Trp Leu Phe His Asp Asp Cys Thr Val Glu
2705                2710                2715                2720
Arg Phe Cys Asp Ser Pro Asp Gly Val Met Leu Cys Gly Ser His Asp
                2725                2730                2735    
Gly Arg Glu Val Tyr Ala Val Thr His Asp Leu Thr Pro Thr Glu Gly
            2740                2745                2750        
Trp Ile Met Gln Phe Lys Ile Ser Val Gly Cys Lys Val Ser Glu Lys
        2755                2760                2765            
Ile Ala Gln Asn Gln Ile His Val Gln Tyr Ser Thr Asp Phe Gly Val
    2770                2775                2780                
Ser Trp Asn Tyr Leu Val Pro Gln Cys Leu Pro Ala Asp Pro Lys Cys
2785                2790                2795                2800
Ser Gly Ser Val Ser Gln Pro Ser Val Phe Phe Pro Thr Lys Gly Trp
                2805                2810                2815    
Lys Arg Ile Thr Tyr Pro Leu Pro Glu Ser Leu Val Gly Asn Pro Val
            2820                2825                2830        
Arg Phe Arg Phe Tyr Gln Lys Tyr Ser Asp Met Gln Trp Ala Ile Asp
        2835                2840                2845            
Asn Phe Tyr Leu Gly Pro Gly Cys Leu Asp Asn Cys Arg Gly His Gly
    2850                2855                2860                
Asp Cys Leu Arg Glu Gln Cys Ile Cys Asp Pro Gly Tyr Ser Gly Pro
2865                2870                2875                2880
Asn Cys Tyr Leu Thr His Thr Leu Lys Thr Phe Leu Lys Glu Arg Phe
                2885                2890                2895    
Asp Ser Glu Glu Ile Lys Pro Asp Leu Trp Met Ser Leu Glu Gly Gly
            2900                2905                2910        
Ser Thr Cys Thr Glu Cys Gly Ile Leu Ala Glu Asp Thr Ala Leu Tyr
        2915                2920                2925            
Phe Gly Gly Ser Thr Val Arg Gln Ala Val Thr Gln Asp Leu Asp Leu
    2930                2935                2940                
Arg Gly Ala Lys Phe Leu Gln Tyr Trp Gly Arg Ile Gly Ser Glu Asn
2945                2950                2955                2960
Asn Met Thr Ser Cys His Arg Pro Ile Cys Arg Lys Glu Gly Val Leu
                2965                2970                2975    
Leu Asp Tyr Ser Thr Asp Gly Gly Ile Thr Trp Thr Leu Leu His Glu
            2980                2985                2990        
Met Asp Tyr Gln Lys Tyr Ile Ser Val Arg His Asp Tyr Ile Leu Leu
        2995                3000                3005            
Pro Glu Asp Ala Leu Thr Asn Thr Thr Arg Leu Arg Trp Trp Gln Pro
    3010                3015                3020                
Phe Val Ile Ser Asn Gly Ile Val Val Ser Gly Val Glu Arg Ala Gln
3025                3030                3035                3040
Trp Ala Leu Asp Asn Ile Leu Ile Gly Gly Ala Glu Ile Asn Pro Ser
                3045                3050                3055    
Gln Leu Val Asp Thr Phe Asp Asp Glu Gly Thr Ser His Glu Glu Asn
            3060                3065                3070        
Trp Ser Phe Tyr Pro Asn Ala Val Arg Thr Ala Gly Phe Cys Gly Asn
        3075                3080                3085            
Pro Ser Phe His Leu Tyr Trp Pro Asn Lys Lys Lys Asp Lys Thr His
    3090                3095                3100                
Asn Ala Leu Ser Ser Arg Glu Leu Ile Ile Gln Pro Gly Tyr Met Met
3105                3110                3115                3120
Gln Phe Lys Ile Val Val Gly Cys Glu Ala Thr Ser Cys Gly Asp Leu
                3125                3130                3135    
His Ser Val Met Leu Glu Tyr Thr Lys Asp Ala Arg Ser Asp Ser Trp
            3140                3145                3150        
Gln Leu Val Gln Thr Gln Cys Leu Pro Ser Ser Ser Asn Ser Ile Gly
        3155                3160                3165            
Cys Ser Pro Phe Gln Phe His Glu Ala Thr Ile Tyr Asn Ser Val Asn
    3170                3175                3180                
Ser Ser Ser Trp Lys Arg Ile Thr Ile Gln Leu Pro Asp His Val Ser
3185                3190                3195                3200
Ser Ser Ala Thr Gln Phe Arg Trp Ile Gln Lys Gly Glu Glu Thr Glu
                3205                3210                3215    
Lys Gln Ser Trp Ala Ile Asp His Val Tyr Ile Gly Glu Ala Cys Pro
            3220                3225                3230        
Lys Leu Cys Ser Gly His Gly Tyr Cys Thr Thr Gly Ala Ile Cys Ile
        3235                3240                3245            
Cys Asp Glu Ser Phe Gln Gly Asp Asp Cys Ser Val Phe Ser His Asp
    3250                3255                3260                
Leu Pro Ser Tyr Ile Lys Asp Asn Phe Glu Ser Ala Arg Val Thr Glu
3265                3270                3275                3280
Ala Asn Trp Glu Thr Ile Gln Gly Gly Val Ile Gly Ser Gly Cys Gly
                3285                3290                3295    
Gln Leu Ala Pro Tyr Ala His Gly Asp Ser Leu Tyr Phe Asn Gly Cys
            3300                3305                3310        
Gln Ile Arg Gln Ala Ala Thr Lys Pro Leu Asp Leu Thr Arg Ala Ser
        3315                3320                3325            
Lys Ile Met Phe Val Leu Gln Ile Gly Ser Met Ser Gln Thr Asp Ser
    3330                3335                3340                
Cys Asn Ser Asp Leu Ser Gly Pro His Ala Val Asp Lys Ala Val Leu
3345                3350                3355                3360
Leu Gln Tyr Ser Val Asn Asn Gly Ile Thr Trp His Val Ile Ala Gln
                3365                3370                3375    
His Gln Pro Lys Asp Phe Thr Gln Ala Gln Arg Val Ser Tyr Asn Val
            3380                3385                3390        
Pro Leu Glu Ala Arg Met Lys Gly Val Leu Leu Arg Trp Trp Gln Pro
        3395                3400                3405            
Arg His Asn Gly Thr Gly His Asp Gln Trp Ala Leu Asp His Val Glu
    3410                3415                3420                
Val Val Leu
3425        


<210> 1625
<211> 198
<212> PRT
<213> Homo sapiens

<400> 1625
Met Ala Ser Gly Asn Ala Arg Ile Gly Lys Pro Ala Pro Asp Phe Lys
 1               5                  10                  15      
Ala Thr Ala Val Val Asp Gly Ala Phe Lys Glu Val Lys Leu Ser Asp
            20                  25                  30          
Tyr Lys Gly Lys Tyr Val Val Leu Phe Phe Tyr Pro Leu Asp Phe Thr
        35                  40                  45              
Phe Val Cys Pro Thr Glu Ile Ile Ala Phe Ser Asn Arg Ala Glu Asp
    50                  55                  60                  
Phe Arg Lys Leu Gly Cys Glu Val Leu Gly Val Ser Val Asp Ser Gln
65                  70                  75                  80  
Phe Thr His Leu Ala Trp Ile Asn Thr Pro Arg Lys Glu Gly Gly Leu
                85                  90                  95      
Gly Pro Leu Asn Ile Pro Leu Leu Ala Asp Val Thr Arg Arg Leu Ser
            100                 105                 110         
Glu Asp Tyr Gly Val Leu Lys Thr Asp Glu Gly Ile Ala Tyr Arg Gly
        115                 120                 125             
Leu Phe Ile Ile Asp Gly Lys Gly Val Leu Arg Gln Ile Thr Val Asn
    130                 135                 140                 
Asp Leu Pro Val Gly Arg Ser Val Asp Glu Ala Leu Arg Leu Val Gln
145                 150                 155                 160 
Ala Phe Gln Tyr Thr Asp Glu His Gly Glu Val Cys Pro Ala Gly Trp
                165                 170                 175     
Lys Pro Gly Ser Asp Thr Ile Lys Pro Asn Val Asp Asp Ser Lys Glu
            180                 185                 190         
Tyr Phe Ser Lys His Asn
        195             


<210> 1626
<211> 242
<212> PRT
<213> Homo sapiens

<400> 1626
Met Ala Ala Pro Ala Val Lys Val Ala Arg Gly Trp Ser Gly Leu Ala
 1               5                  10                  15      
Leu Gly Val Arg Arg Ala Val Leu Gln Leu Pro Gly Leu Thr Gln Val
            20                  25                  30          
Arg Trp Ser Arg Tyr Ser Pro Glu Phe Lys Asp Pro Leu Ile Asp Lys
        35                  40                  45              
Glu Tyr Tyr Arg Lys Pro Val Glu Glu Leu Thr Glu Glu Glu Lys Tyr
    50                  55                  60                  
Val Arg Glu Leu Lys Lys Thr Gln Leu Ile Lys Ala Ala Pro Ala Gly
65                  70                  75                  80  
Lys Thr Ser Ser Val Phe Glu Asp Pro Val Ile Ser Lys Phe Thr Asn
                85                  90                  95      
Met Met Met Ile Gly Gly Asn Lys Val Leu Ala Arg Ser Leu Met Ile
            100                 105                 110         
Gln Thr Leu Glu Ala Val Lys Arg Lys Gln Phe Glu Lys Tyr His Ala
        115                 120                 125             
Ala Ser Ala Glu Glu Gln Ala Thr Ile Glu Arg Asn Pro Tyr Thr Ile
    130                 135                 140                 
Phe His Gln Ala Leu Lys Asn Cys Glu Pro Met Ile Gly Leu Val Pro
145                 150                 155                 160 
Ile Leu Lys Gly Gly Arg Phe Tyr Gln Val Pro Val Pro Leu Pro Asp
                165                 170                 175     
Arg Arg Arg Arg Phe Leu Ala Met Lys Trp Met Ile Thr Glu Cys Arg
            180                 185                 190         
Asp Lys Lys His Gln Arg Thr Leu Met Pro Glu Lys Leu Ser His Lys
        195                 200                 205             
Leu Leu Glu Ala Phe His Asn Gln Gly Pro Val Ile Lys Arg Lys His
    210                 215                 220                 
Asp Leu His Lys Met Ala Glu Ala Asn Arg Ala Leu Ala His Tyr Arg
225                 230                 235                 240 
Trp Trp
        


<210> 1627
<211> 274
<212> PRT
<213> Homo sapiens

<400> 1627
Met Leu Ser Val Ala Ser Arg Ser Gly Pro Phe Ala Pro Val Leu Ser
 1               5                  10                  15      
Ala Thr Ser Arg Gly Val Ala Gly Ala Leu Arg Pro Leu Val Gln Ala
            20                  25                  30          
Thr Val Pro Ala Thr Pro Glu Gln Pro Val Leu Asp Leu Lys Arg Pro
        35                  40                  45              
Phe Leu Ser Arg Glu Ser Leu Ser Gly Gln Ala Val Arg Arg Pro Leu
    50                  55                  60                  
Val Ala Ser Val Gly Leu Asn Val Pro Ala Ser Val Cys Tyr Ser His
65                  70                  75                  80  
Thr Asp Ile Lys Val Pro Asp Phe Ser Glu Tyr Arg Arg Leu Glu Val
                85                  90                  95      
Leu Asp Ser Thr Lys Ser Ser Arg Glu Ser Ser Glu Ala Arg Lys Gly
            100                 105                 110         
Phe Ser Tyr Leu Val Thr Gly Val Thr Thr Val Gly Val Ala Tyr Ala
        115                 120                 125             
Ala Lys Asn Ala Val Thr Gln Phe Val Ser Ser Met Ser Ala Ser Ala
    130                 135                 140                 
Asp Val Leu Ala Leu Ala Lys Ile Glu Ile Lys Leu Ser Asp Ile Pro
145                 150                 155                 160 
Glu Gly Lys Asn Met Ala Phe Lys Trp Arg Gly Lys Pro Leu Phe Val
                165                 170                 175     
Arg His Arg Thr Gln Lys Glu Ile Glu Gln Glu Ala Ala Val Glu Leu
            180                 185                 190         
Ser Gln Leu Arg Asp Pro Gln His Asp Leu Asp Arg Val Lys Lys Pro
        195                 200                 205             
Glu Trp Val Ile Leu Ile Gly Val Cys Thr His Leu Gly Cys Val Pro
    210                 215                 220                 
Ile Ala Asn Ala Gly Asp Phe Gly Gly Tyr Tyr Cys Pro Cys His Gly
225                 230                 235                 240 
Ser His Tyr Asp Ala Ser Gly Arg Ile Arg Leu Gly Pro Ala Pro Leu
                245                 250                 255     
Asn Leu Glu Val Pro Thr Tyr Glu Phe Thr Ser Asp Asp Met Val Ile
            260                 265                 270         
Val Gly
        


<210> 1628
<211> 495
<212> PRT
<213> Homo sapiens

<400> 1628
Met Glu Phe Arg Lys Leu Arg Gly Met Glu Thr Arg Pro Pro Ala Asn
 1               5                  10                  15      
Thr Ala Arg Leu Gln Pro Pro Arg Asp Leu Arg Ser Ser Ser Pro Arg
            20                  25                  30          
Lys Gln Leu Ser Glu Ser Ser Asp Asp Asp Tyr Asp Asp Val Asp Ile
        35                  40                  45              
Pro Thr Pro Ala Glu Asp Thr Pro Pro Pro Leu Pro Pro Lys Pro Lys
    50                  55                  60                  
Phe Arg Ser Pro Ser Asp Glu Gly Pro Gly Ser Met Gly Asp Asp Gly
65                  70                  75                  80  
Gln Leu Ser Pro Gly Val Leu Val Arg Cys Ala Ser Gly Pro Pro Pro
                85                  90                  95      
Asn Ser Pro Arg Pro Gly Pro Pro Pro Ser Thr Ser Ser Pro His Leu
            100                 105                 110         
Thr Ala His Ser Glu Pro Ser Leu Trp Asn Pro Pro Ser Arg Glu Leu
        115                 120                 125             
Asp Lys Pro Pro Leu Leu Pro Pro Lys Lys Glu Lys Met Lys Arg Lys
    130                 135                 140                 
Gly Cys Ala Leu Leu Val Lys Leu Phe Asn Gly Cys Pro Leu Arg Ile
145                 150                 155                 160 
His Ser Thr Ala Ala Trp Thr His Pro Ser Thr Lys Asp Gln His Leu
                165                 170                 175     
Leu Leu Gly Ala Glu Glu Gly Ile Phe Ile Leu Asn Arg Asn Asp Gln
            180                 185                 190         
Glu Ala Thr Leu Glu Met Leu Phe Pro Ser Arg Thr Thr Trp Val Tyr
        195                 200                 205             
Ser Ile Asn Asn Val Leu Met Ser Leu Ser Gly Lys Thr Pro His Leu
    210                 215                 220                 
Tyr Ser His Ser Ile Leu Gly Leu Leu Glu Arg Lys Glu Thr Arg Ala
225                 230                 235                 240 
Gly Asn Pro Ile Ala His Ile Ser Pro His Arg Leu Leu Ala Arg Lys
                245                 250                 255     
Asn Met Val Ser Thr Lys Ile Gln Asp Thr Lys Gly Cys Arg Ala Cys
            260                 265                 270         
Cys Val Ala Glu Gly Ala Ser Ser Gly Gly Pro Phe Leu Cys Gly Ala
        275                 280                 285             
Leu Glu Thr Ser Val Val Leu Leu Gln Trp Tyr Gln Pro Met Asn Lys
    290                 295                 300                 
Phe Leu Leu Val Arg Gln Val Leu Phe Pro Leu Pro Thr Pro Leu Ser
305                 310                 315                 320 
Val Phe Ala Leu Leu Thr Gly Pro Gly Ser Glu Leu Pro Ala Val Cys
                325                 330                 335     
Ile Gly Val Ser Pro Gly Arg Pro Gly Lys Ser Val Leu Phe His Thr
            340                 345                 350         
Val Arg Phe Gly Ala Leu Ser Cys Trp Leu Gly Glu Met Ser Thr Glu
        355                 360                 365             
His Arg Gly Pro Val Gln Val Thr Gln Val Glu Glu Asp Met Val Met
    370                 375                 380                 
Val Leu Met Asp Gly Ser Val Lys Leu Val Thr Pro Glu Gly Ser Pro
385                 390                 395                 400 
Val Arg Gly Leu Arg Thr Pro Glu Ile Pro Met Thr Glu Ala Val Glu
                405                 410                 415     
Ala Val Ala Met Val Gly Gly Gln Leu Gln Ala Phe Trp Lys His Gly
            420                 425                 430         
Val Gln Val Trp Ala Leu Gly Ser Asp Gln Leu Leu Gln Glu Leu Arg
        435                 440                 445             
Asp Pro Thr Leu Thr Phe Arg Leu Leu Gly Ser Pro Arg Leu Glu Cys
    450                 455                 460                 
Ser Gly Thr Ile Ser Pro His Cys Asn Leu Leu Leu Pro Gly Ser Ser
465                 470                 475                 480 
Asn Ser Pro Ala Ser Ala Ser Arg Val Ala Gly Ile Thr Gly Leu
                485                 490                 495 


<210> 1629
<211> 1938
<212> PRT
<213> Homo sapiens

<400> 1629
Met Ser Ser Asp Ala Glu Met Ala Ile Phe Gly Glu Ala Ala Pro Tyr
 1               5                  10                  15      
Leu Arg Lys Pro Glu Lys Glu Arg Ile Glu Ala Gln Asn Arg Pro Phe
            20                  25                  30          
Asp Ser Lys Lys Ala Cys Phe Val Ala Asp Asn Lys Glu Met Tyr Val
        35                  40                  45              
Lys Gly Met Ile Gln Thr Arg Glu Asn Asp Lys Val Ile Val Lys Thr
    50                  55                  60                  
Leu Asp Asp Arg Met Leu Thr Leu Asn Asn Asp Gln Val Phe Pro Met
65                  70                  75                  80  
Asn Pro Pro Lys Phe Asp Lys Ile Glu Asp Met Ala Met Met Thr His
                85                  90                  95      
Leu His Glu Pro Ala Val Leu Tyr Asn Leu Lys Glu Arg Tyr Ala Ala
            100                 105                 110         
Trp Met Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Thr Val Asn Pro
        115                 120                 125             
Tyr Lys Trp Leu Pro Val Tyr Lys Pro Glu Val Val Ala Ala Tyr Arg
    130                 135                 140                 
Gly Lys Lys Arg Gln Glu Ala Pro Pro His Ile Phe Ser Ile Ser Asp
145                 150                 155                 160 
Asn Ala Tyr Gln Phe Met Leu Thr Asp Arg Asp Asn Gln Ser Ile Leu
                165                 170                 175     
Ile Thr Gly Glu Ser Gly Ala Gly Lys Thr Val Asn Thr Lys Arg Val
            180                 185                 190         
Ile Gln Tyr Phe Ala Thr Ile Ala Val Thr Gly Asp Lys Lys Lys Glu
        195                 200                 205             
Thr Gln Pro Gly Lys Met Gln Gly Thr Leu Glu Asp Gln Ile Ile Gln
    210                 215                 220                 
Ala Asn Pro Leu Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Arg Asn
225                 230                 235                 240 
Asp Asn Ser Ser Arg Phe Gly Lys Phe Ile Arg Ile His Phe Gly Ala
                245                 250                 255     
Thr Gly Lys Leu Ala Ser Ala Asp Ile Glu Thr Tyr Leu Leu Glu Lys
            260                 265                 270         
Ser Arg Val Thr Phe Gln Leu Ser Ser Glu Arg Ser Tyr His Ile Phe
        275                 280                 285             
Tyr Gln Ile Met Ser Asn Lys Lys Pro Glu Leu Ile Asp Leu Leu Leu
    290                 295                 300                 
Ile Ser Thr Asn Pro Phe Asp Phe Pro Phe Val Ser Gln Gly Glu Val
305                 310                 315                 320 
Thr Val Ala Ser Ile Asp Asp Ser Glu Glu Leu Leu Ala Thr Asp Asn
                325                 330                 335     
Ala Ile Asp Ile Leu Gly Phe Ser Ser Glu Glu Lys Val Gly Ile Tyr
            340                 345                 350         
Lys Leu Thr Gly Ala Val Met His Tyr Gly Asn Met Lys Phe Lys Gln
        355                 360                 365             
Lys Gln Arg Glu Glu Gln Ala Glu Pro Asp Gly Thr Glu Val Ala Asp
    370                 375                 380                 
Lys Ala Gly Tyr Leu Met Gly Leu Asn Ser Ala Glu Met Leu Lys Gly
385                 390                 395                 400 
Leu Cys Cys Pro Arg Val Lys Val Gly Asn Glu Tyr Val Thr Lys Gly
                405                 410                 415     
Gln Asn Val Gln Gln Val Thr Asn Ser Val Gly Ala Leu Ala Lys Ala
            420                 425                 430         
Val Tyr Glu Lys Met Phe Leu Trp Met Val Thr Arg Ile Asn Gln Gln
        435                 440                 445             
Leu Asp Thr Lys Gln Pro Arg Gln Tyr Phe Ile Gly Val Leu Asp Ile
    450                 455                 460                 
Ala Gly Phe Glu Ile Phe Asp Phe Asn Ser Leu Glu Gln Leu Cys Ile
465                 470                 475                 480 
Asn Phe Thr Asn Glu Lys Leu Gln Gln Phe Phe Asn His His Met Phe
                485                 490                 495     
Val Leu Glu Gln Glu Glu Tyr Lys Lys Glu Gly Ile Glu Trp Glu Phe
            500                 505                 510         
Ile Asp Phe Gly Met Asp Leu Ala Ala Cys Ile Glu Leu Ile Glu Lys
        515                 520                 525             
Pro Met Gly Ile Phe Ser Ile Leu Glu Glu Glu Cys Met Phe Pro Lys
    530                 535                 540                 
Ala Thr Asp Thr Ser Phe Lys Asn Lys Leu Tyr Asp Gln His Leu Gly
545                 550                 555                 560 
Lys Ser Asn Asn Phe Gln Lys Pro Lys Pro Ala Lys Gly Lys Ala Glu
                565                 570                 575     
Ala His Phe Ser Leu Val His Tyr Ala Gly Thr Val Asp Tyr Asn Ile
            580                 585                 590         
Ala Gly Trp Leu Asp Lys Asn Lys Asp Pro Leu Asn Glu Thr Val Val
        595                 600                 605             
Gly Leu Tyr Gln Lys Ser Ser Leu Lys Leu Leu Ser Phe Leu Phe Ser
    610                 615                 620                 
Asn Tyr Ala Gly Ala Glu Thr Gly Asp Ser Gly Gly Ser Lys Lys Gly
625                 630                 635                 640 
Gly Lys Lys Lys Gly Ser Ser Phe Gln Thr Val Ser Ala Val Phe Arg
                645                 650                 655     
Glu Asn Leu Asn Lys Leu Met Thr Asn Leu Arg Ser Thr His Pro His
            660                 665                 670         
Phe Val Arg Cys Leu Ile Pro Asn Glu Thr Lys Thr Pro Gly Val Met
        675                 680                 685             
Asp His Tyr Leu Val Met His Gln Leu Arg Cys Asn Gly Val Leu Glu
    690                 695                 700                 
Gly Ile Arg Ile Cys Arg Lys Gly Phe Pro Ser Arg Ile Leu Tyr Ala
705                 710                 715                 720 
Asp Phe Lys Gln Arg Tyr Arg Ile Leu Asn Ala Ser Ala Ile Pro Glu
                725                 730                 735     
Gly Gln Phe Ile Asp Ser Lys Asn Ala Ser Glu Lys Leu Leu Asn Ser
            740                 745                 750         
Ile Asp Val Asp Arg Glu Gln Phe Arg Phe Gly Asn Thr Lys Val Phe
        755                 760                 765             
Phe Lys Ala Gly Leu Leu Gly Leu Leu Glu Glu Met Arg Asp Glu Lys
    770                 775                 780                 
Leu Val Thr Leu Met Thr Ser Thr Gln Ala Val Cys Arg Gly Tyr Leu
785                 790                 795                 800 
Met Arg Val Glu Phe Lys Lys Met Met Glu Arg Arg Asp Ser Ile Phe
                805                 810                 815     
Cys Ile Gln Tyr Asn Ile Arg Ser Phe Met Asn Val Lys His Trp Pro
            820                 825                 830         
Trp Met Asn Leu Phe Phe Lys Ile Lys Pro Leu Leu Lys Ser Ala Glu
        835                 840                 845             
Ala Glu Lys Glu Met Ala Thr Met Lys Glu Asp Phe Glu Arg Thr Lys
    850                 855                 860                 
Glu Glu Leu Ala Arg Ser Glu Ala Arg Arg Lys Glu Leu Glu Glu Lys
865                 870                 875                 880 
Met Val Ser Leu Leu Gln Glu Lys Asn Asp Leu Gln Leu Gln Val Gln
                885                 890                 895     
Ser Glu Thr Glu Asn Leu Met Asp Ala Glu Glu Arg Cys Glu Gly Leu
            900                 905                 910         
Ile Lys Ser Lys Ile Leu Leu Glu Ala Lys Val Lys Glu Leu Thr Glu
        915                 920                 925             
Arg Leu Glu Glu Glu Glu Glu Met Asn Ser Glu Leu Val Ala Lys Lys
    930                 935                 940                 
Arg Asn Leu Glu Asp Lys Cys Ser Ser Leu Lys Arg Asp Ile Asp Asp
945                 950                 955                 960 
Leu Glu Leu Thr Leu Thr Lys Val Glu Lys Glu Lys His Ala Thr Glu
                965                 970                 975     
Asn Lys Val Lys Asn Leu Ser Glu Glu Met Thr Ala Leu Glu Glu Asn
            980                 985                 990         
Ile Ser Lys Leu Thr Lys Glu Lys Lys Ser Leu Gln Glu Ala His Gln
        995                 1000                1005            
Gln Thr Leu Asp Asp Leu Gln Val Glu Glu Asp Lys Val Asn Gly Leu
    1010                1015                1020                
Ile Lys Ile Asn Ala Lys Leu Glu Gln Gln Thr Asp Asp Leu Glu Gly
1025                1030                1035                1040
Ser Leu Glu Gln Glu Lys Lys Leu Arg Ala Asp Leu Glu Arg Ala Lys
                1045                1050                1055    
Arg Lys Leu Glu Gly Asp Leu Lys Met Ser Gln Glu Ser Ile Met Asp
            1060                1065                1070        
Leu Glu Asn Asp Lys Gln Gln Ile Glu Glu Lys Leu Lys Lys Lys Glu
        1075                1080                1085            
Phe Glu Leu Ser Gln Leu Gln Ala Lys Ile Asp Asp Glu Gln Val His
    1090                1095                1100                
Ser Leu Gln Phe Gln Lys Lys Ile Lys Glu Leu Gln Ala Arg Ile Glu
1105                1110                1115                1120
Glu Leu Glu Glu Glu Ile Glu Ala Glu His Thr Leu Arg Ala Lys Ile
                1125                1130                1135    
Glu Lys Gln Arg Ser Asp Leu Ala Arg Glu Leu Glu Glu Ile Ser Glu
            1140                1145                1150        
Arg Leu Glu Glu Ala Ser Gly Ala Thr Ser Ala Gln Ile Glu Met Asn
        1155                1160                1165            
Lys Lys Arg Glu Ala Glu Phe Gln Lys Met Arg Arg Asp Leu Glu Glu
    1170                1175                1180                
Ala Thr Leu Gln His Glu Ala Thr Ala Ala Thr Leu Arg Lys Lys Gln
1185                1190                1195                1200
Ala Asp Ser Val Ala Glu Leu Gly Glu Gln Ile Asp Asn Leu Gln Arg
                1205                1210                1215    
Val Lys Gln Lys Leu Glu Lys Glu Lys Ser Glu Leu Lys Met Glu Ile
            1220                1225                1230        
Asp Asp Met Ala Ser Asn Ile Glu Ala Leu Ser Lys Ser Lys Ser Asn
        1235                1240                1245            
Ile Glu Arg Thr Cys Arg Thr Val Glu Asp Gln Phe Ser Glu Ile Lys
    1250                1255                1260                
Ala Lys Asp Glu Gln Gln Thr Gln Leu Ile His Asp Leu Asn Met Gln
1265                1270                1275                1280
Lys Ala Arg Leu Gln Thr Gln Asn Gly Glu Leu Ser His Arg Val Glu
                1285                1290                1295    
Glu Lys Glu Ser Leu Ile Ser Gln Leu Thr Lys Ser Lys Gln Ala Leu
            1300                1305                1310        
Thr Gln Gln Leu Glu Glu Leu Lys Arg Gln Met Glu Glu Glu Thr Lys
        1315                1320                1325            
Ala Lys Asn Ala Met Ala His Ala Leu Gln Ser Ser Arg His Asp Cys
    1330                1335                1340                
Asp Leu Leu Arg Glu Gln Tyr Glu Glu Glu Gln Glu Ala Lys Ala Glu
1345                1350                1355                1360
Leu Gln Arg Ala Leu Ser Lys Ala Asn Ser Glu Val Ala Gln Trp Arg
                1365                1370                1375    
Thr Lys Tyr Glu Thr Asp Ala Ile Gln Arg Thr Glu Glu Leu Glu Glu
            1380                1385                1390        
Ala Lys Lys Lys Leu Ala Gln Arg Leu Gln Glu Ala Glu Glu Asn Thr
        1395                1400                1405            
Glu Thr Ala Asn Ser Lys Cys Ala Ser Leu Glu Lys Thr Lys Gln Arg
    1410                1415                1420                
Leu Gln Gly Glu Val Glu Asp Leu Met Arg Asp Leu Glu Arg Ser His
1425                1430                1435                1440
Thr Ala Cys Ala Thr Leu Asp Lys Lys Gln Arg Asn Phe Asp Lys Val
                1445                1450                1455    
Leu Ala Glu Trp Lys Gln Lys Leu Asp Glu Ser Gln Ala Glu Leu Glu
            1460                1465                1470        
Ala Ala Gln Lys Glu Ser Arg Ser Leu Ser Thr Glu Leu Phe Lys Met
        1475                1480                1485            
Arg Asn Ala Tyr Glu Glu Val Val Asp Gln Leu Glu Thr Leu Arg Arg
    1490                1495                1500                
Glu Asn Lys Asn Leu Gln Glu Glu Ile Ser Asp Leu Thr Glu Gln Ile
1505                1510                1515                1520
Ala Glu Thr Gly Lys Asn Leu Gln Glu Ala Glu Lys Thr Lys Lys Leu
                1525                1530                1535    
Val Glu Gln Glu Lys Ser Asp Leu Gln Val Ala Leu Glu Glu Val Glu
            1540                1545                1550        
Gly Ser Leu Glu His Glu Glu Ser Lys Ile Leu Arg Val Gln Leu Glu
        1555                1560                1565            
Leu Ser Gln Val Lys Ser Glu Leu Asp Arg Lys Val Ile Glu Lys Asp
    1570                1575                1580                
Glu Glu Ile Glu Gln Leu Lys Arg Asn Ser Gln Arg Ala Ala Glu Ala
1585                1590                1595                1600
Leu Gln Ser Val Leu Asp Ala Glu Ile Arg Ser Arg Asn Asp Ala Leu
                1605                1610                1615    
Arg Leu Lys Lys Lys Met Glu Gly Asp Leu Asn Glu Met Glu Ile Gln
            1620                1625                1630        
Leu Gly His Ser Asn Arg Gln Met Ala Glu Thr Gln Lys His Leu Arg
        1635                1640                1645            
Thr Val Gln Gly Gln Leu Lys Asp Ser Gln Leu His Leu Asp Asp Ala
    1650                1655                1660                
Leu Arg Ser Asn Glu Asp Leu Lys Glu Gln Leu Ala Ile Val Glu Arg
1665                1670                1675                1680
Arg Asn Gly Leu Leu Leu Glu Glu Leu Glu Glu Met Lys Val Ala Leu
                1685                1690                1695    
Glu Gln Thr Glu Arg Thr Arg Arg Leu Ser Glu Gln Glu Leu Leu Asp
            1700                1705                1710        
Ala Ser Asp Arg Val Gln Leu Leu His Ser Gln Asn Thr Ser Leu Ile
        1715                1720                1725            
Asn Thr Lys Lys Lys Leu Glu Ala Asp Ile Ala Gln Cys Gln Ala Glu
    1730                1735                1740                
Val Glu Asn Ser Ile Gln Glu Ser Arg Asn Ala Glu Glu Lys Ala Lys
1745                1750                1755                1760
Lys Ala Ile Thr Asp Ala Ala Met Met Ala Glu Glu Leu Lys Lys Glu
                1765                1770                1775    
Gln Asp Thr Ser Ala His Leu Glu Arg Met Lys Lys Asn Leu Glu Gln
            1780                1785                1790        
Thr Val Lys Asp Leu Gln His Arg Leu Asp Glu Ala Glu Gln Leu Ala
        1795                1800                1805            
Leu Lys Gly Gly Lys Lys Gln Ile Gln Lys Leu Glu Asn Arg Val Arg
    1810                1815                1820                
Glu Leu Glu Asn Glu Leu Asp Val Glu Gln Lys Arg Gly Ala Glu Ala
1825                1830                1835                1840
Leu Lys Gly Ala His Lys Tyr Glu Arg Lys Val Lys Glu Met Thr Tyr
                1845                1850                1855    
Gln Ala Glu Glu Asp His Lys Asn Ile Leu Arg Leu Gln Asp Leu Val
            1860                1865                1870        
Asp Lys Leu Gln Ala Lys Val Lys Ser Tyr Lys Arg Gln Ala Glu Glu
        1875                1880                1885            
Ala Glu Glu Gln Ala Asn Thr Gln Leu Ser Arg Cys Arg Arg Val Gln
    1890                1895                1900                
His Glu Leu Glu Glu Ala Ala Glu Arg Ala Asp Ile Ala Glu Ser Gln
1905                1910                1915                1920
Val Asn Lys Leu Arg Ala Lys Ser Arg Asp Val Gly Ser Gln Lys Met
                1925                1930                1935    
Glu Glu
        


<210> 1630
<211> 373
<212> PRT
<213> Homo sapiens

<400> 1630
Met Lys Pro Val Pro Gly Thr Pro Pro Ser Ser Lys Ala Lys Ser Pro
 1               5                  10                  15      
Ile Ser Ser Gly Ser Gly Gly Ser His Met Ser Gly Thr Ser Ser Ser
            20                  25                  30          
Ser Gly Met Lys Ser Ser Ser Gly Leu Gly Ser Ser Gly Ser Leu Ser
        35                  40                  45              
Gln Lys Thr Pro Pro Ser Ser Asn Ser Cys Thr Ala Ser Ser Ser Ser
    50                  55                  60                  
Phe Ser Ser Ser Gly Ser Ser Met Ser Ser Ser Gln Asn Gln His Gly
65                  70                  75                  80  
Ser Ser Lys Gly Lys Ser Pro Ser Arg Asn Lys Lys Pro Ser Leu Thr
                85                  90                  95      
Ala Val Ile Asp Lys Leu Lys His Gly Val Val Thr Ser Gly Pro Gly
            100                 105                 110         
Gly Glu Asp Pro Leu Asp Gly Gln Met Gly Val Ser Thr Asn Ser Ser
        115                 120                 125             
Ser His Pro Met Ser Ser Lys His Asn Met Ser Gly Gly Glu Phe Gln
    130                 135                 140                 
Gly Lys Arg Glu Lys Ser Asp Lys Asp Lys Ser Lys Val Ser Thr Ser
145                 150                 155                 160 
Gly Ser Ser Val Asp Ser Ser Lys Lys Thr Ser Glu Ser Lys Asn Val
                165                 170                 175     
Gly Ser Thr Gly Val Ala Lys Ile Ile Ile Ser Lys His Asp Gly Gly
            180                 185                 190         
Ser Pro Ser Ile Lys Ala Lys Val Thr Leu Gln Lys Pro Gly Glu Ser
        195                 200                 205             
Ser Gly Glu Gly Leu Arg Pro Gln Met Ala Ser Ser Lys Asn Tyr Gly
    210                 215                 220                 
Ser Pro Leu Ile Ser Gly Ser Thr Pro Lys His Glu Arg Gly Ser Pro
225                 230                 235                 240 
Ser His Ser Lys Ser Pro Ala Tyr Thr Pro Gln Asn Leu Asp Ser Glu
                245                 250                 255     
Ser Glu Ser Gly Ser Ser Ile Ala Glu Lys Ser Tyr Gln Asn Ser Pro
            260                 265                 270         
Ser Ser Asp Asp Gly Ile Arg Pro Leu Pro Glu Tyr Ser Thr Glu Lys
        275                 280                 285             
His Lys Lys His Lys Lys Glu Lys Lys Lys Val Lys Asp Lys Asp Arg
    290                 295                 300                 
Asp Arg Asp Arg Asp Lys Asp Arg Asp Lys Lys Lys Ser His Ser Ile
305                 310                 315                 320 
Lys Pro Glu Ser Trp Ser Lys Ser Pro Ile Ser Ser Asp Gln Ser Leu
                325                 330                 335     
Ser Met Thr Ser Asn Thr Ile Leu Ser Ala Asp Arg Pro Ser Arg Leu
            340                 345                 350         
Ser Pro Asp Phe Met Ile Gly Glu Glu Asp Asp Asp Leu Met Asp Val
        355                 360                 365             
Ala Leu Ile Gly Asn
    370             


<210> 1631
<211> 298
<212> PRT
<213> Homo sapiens

<400> 1631
Met Thr Asp Ala Ala Val Ser Phe Ala Lys Asp Phe Leu Ala Gly Gly
 1               5                  10                  15      
Val Ala Ala Ala Ile Ser Lys Thr Ala Val Ala Pro Ile Glu Arg Val
            20                  25                  30          
Lys Leu Leu Leu Gln Val Gln His Ala Ser Lys Gln Ile Thr Ala Asp
        35                  40                  45              
Lys Gln Tyr Lys Gly Ile Ile Asp Cys Val Val Arg Ile Pro Lys Glu
    50                  55                  60                  
Gln Gly Val Leu Ser Phe Trp Arg Gly Asn Leu Ala Asn Val Ile Arg
65                  70                  75                  80  
Tyr Phe Pro Thr Gln Ala Leu Asn Phe Ala Phe Lys Asp Lys Tyr Lys
                85                  90                  95      
Gln Ile Phe Leu Gly Gly Val Asp Lys Arg Thr Gln Phe Trp Leu Tyr
            100                 105                 110         
Phe Ala Gly Asn Leu Ala Ser Gly Gly Ala Ala Gly Ala Thr Ser Leu
        115                 120                 125             
Cys Phe Val Tyr Pro Leu Asp Phe Ala Arg Thr Arg Leu Ala Ala Asp
    130                 135                 140                 
Val Gly Lys Ala Gly Ala Glu Arg Glu Phe Arg Gly Leu Gly Asp Cys
145                 150                 155                 160 
Leu Val Lys Ile Tyr Lys Ser Asp Gly Ile Lys Gly Leu Tyr Gln Gly
                165                 170                 175     
Phe Asn Val Ser Val Gln Gly Ile Ile Ile Tyr Arg Ala Ala Tyr Phe
            180                 185                 190         
Gly Ile Tyr Asp Thr Ala Lys Gly Met Leu Pro Asp Pro Lys Asn Thr
        195                 200                 205             
His Ile Val Ile Ser Trp Met Ile Ala Gln Thr Val Thr Ala Val Ala
    210                 215                 220                 
Gly Leu Thr Ser Tyr Pro Phe Asp Thr Val Arg Arg Arg Met Met Met
225                 230                 235                 240 
Gln Ser Gly Arg Lys Gly Thr Asp Ile Met Tyr Thr Gly Thr Leu Asp
                245                 250                 255     
Cys Trp Arg Lys Ile Ala Arg Asp Glu Gly Gly Lys Ala Phe Phe Lys
            260                 265                 270         
Gly Ala Trp Ser Asn Val Leu Arg Gly Met Gly Gly Ala Phe Val Leu
        275                 280                 285             
Val Leu Tyr Asp Glu Ile Lys Lys Tyr Thr
    290                 295             


<210> 1632
<211> 562
<212> PRT
<213> Homo sapiens

<400> 1632
Met Val Lys Ile Val Thr Val Lys Thr Gln Ala Tyr Gln Asp Gln Lys
 1               5                  10                  15      
Pro Gly Thr Ser Gly Leu Arg Lys Arg Val Lys Val Phe Gln Ser Ser
            20                  25                  30          
Ala Asn Tyr Ala Glu Asn Phe Ile Gln Ser Ile Ile Ser Thr Val Glu
        35                  40                  45              
Pro Ala Gln Arg Gln Glu Ala Thr Leu Val Val Gly Gly Asp Gly Arg
    50                  55                  60                  
Phe Tyr Met Lys Glu Ala Ile Gln Leu Ile Ala Arg Ile Ala Ala Ala
65                  70                  75                  80  
Asn Gly Ile Gly Arg Leu Val Ile Gly Gln Asn Gly Ile Leu Ser Thr
                85                  90                  95      
Pro Ala Val Ser Cys Ile Ile Arg Lys Ile Lys Ala Ile Gly Gly Ile
            100                 105                 110         
Ile Leu Thr Ala Ser His Asn Pro Gly Gly Pro Asn Gly Asp Phe Gly
        115                 120                 125             
Ile Lys Phe Asn Ile Ser Asn Gly Gly Pro Ala Pro Glu Ala Ile Thr
    130                 135                 140                 
Asp Lys Ile Phe Gln Ile Ser Lys Thr Ile Glu Glu Tyr Ala Val Cys
145                 150                 155                 160 
Pro Asp Leu Lys Val Asp Leu Gly Val Leu Gly Lys Gln Gln Phe Asp
                165                 170                 175     
Leu Glu Asn Lys Phe Lys Pro Phe Thr Val Glu Ile Val Asp Ser Val
            180                 185                 190         
Glu Ala Tyr Ala Thr Met Leu Arg Ser Ile Phe Asp Phe Ser Ala Leu
        195                 200                 205             
Lys Glu Leu Leu Ser Gly Pro Asn Arg Leu Lys Ile Arg Ile Asp Ala
    210                 215                 220                 
Met His Gly Val Val Gly Pro Tyr Val Lys Lys Ile Leu Cys Glu Glu
225                 230                 235                 240 
Leu Gly Ala Pro Ala Asn Ser Ala Val Asn Cys Val Pro Leu Glu Asp
                245                 250                 255     
Phe Gly Gly His His Pro Asp Pro Asn Leu Thr Tyr Ala Ala Asp Leu
            260                 265                 270         
Val Glu Thr Met Lys Ser Gly Glu His Asp Phe Gly Ala Ala Phe Asp
        275                 280                 285             
Gly Asp Gly Asp Arg Asn Met Ile Leu Gly Lys His Gly Phe Phe Val
    290                 295                 300                 
Asn Pro Ser Asp Ser Val Ala Val Ile Ala Ala Asn Ile Phe Ser Ile
305                 310                 315                 320 
Pro Tyr Phe Gln Gln Thr Gly Val Arg Gly Phe Ala Arg Ser Met Pro
                325                 330                 335     
Thr Ser Gly Ala Leu Asp Arg Val Ala Ser Ala Thr Lys Ile Ala Leu
            340                 345                 350         
Tyr Glu Thr Pro Thr Gly Trp Lys Phe Phe Gly Asn Leu Met Asp Ala
        355                 360                 365             
Ser Lys Leu Ser Leu Cys Gly Glu Glu Ser Phe Gly Thr Gly Ser Asp
    370                 375                 380                 
His Ile Arg Glu Lys Asp Gly Leu Trp Ala Val Leu Ala Trp Leu Ser
385                 390                 395                 400 
Ile Leu Ala Thr Arg Lys Gln Ser Val Glu Asp Ile Leu Lys Asp His
                405                 410                 415     
Trp Gln Lys Tyr Gly Arg Asn Phe Phe Thr Arg Tyr Asp Tyr Glu Glu
            420                 425                 430         
Val Glu Ala Glu Gly Ala Asn Lys Met Met Lys Asp Leu Glu Ala Leu
        435                 440                 445             
Met Phe Asp Arg Ser Phe Val Gly Lys Gln Phe Ser Ala Asn Asp Lys
    450                 455                 460                 
Val Tyr Thr Val Glu Lys Ala Asp Asn Phe Glu Tyr Ser Asp Pro Val
465                 470                 475                 480 
Asp Gly Ser Ile Ser Arg Asn Gln Gly Leu Arg Leu Ile Phe Thr Asp
                485                 490                 495     
Gly Ser Arg Ile Val Phe Arg Leu Ser Gly Thr Gly Ser Ala Gly Ala
            500                 505                 510         
Thr Ile Arg Leu Tyr Ile Asp Ser Tyr Glu Lys Asp Val Ala Lys Ile
        515                 520                 525             
Asn Gln Asp Pro Gln Val Met Leu Ala Pro Leu Ile Ser Ile Ala Leu
    530                 535                 540                 
Lys Val Ser Gln Leu Gln Glu Arg Thr Gly Arg Thr Ala Pro Thr Val
545                 550                 555                 560 
Ile Thr
        


<210> 1633
<211> 477
<212> PRT
<213> Homo sapiens

<400> 1633
Met Thr Cys Ser Lys Leu Leu Val Met Glu Leu Cys Phe Gly Lys Met
 1               5                  10                  15      
Ile Asn Leu Ser Val Pro Asp Thr Ile Asp Glu Arg Ala Ile Asn Lys
            20                  25                  30          
Lys Lys Leu Thr Pro Phe Ile Ile Gln Glu Asn Leu Asn Leu Ala Leu
        35                  40                  45              
Asn Ser Ala Ser Ala Ile Gly Cys His Val Val Asn Ile Gly Ala Glu
    50                  55                  60                  
Asp Leu Arg Ala Gly Lys Pro His Leu Val Leu Gly Leu Leu Trp Gln
65                  70                  75                  80  
Ile Ile Lys Ile Gly Leu Phe Ala Asp Ile Glu Leu Ser Arg Asn Glu
                85                  90                  95      
Ala Leu Ala Ala Leu Leu Arg Asp Gly Glu Thr Leu Glu Glu Leu Met
            100                 105                 110         
Lys Leu Ser Pro Glu Glu Leu Leu Leu Arg Trp Ala Asn Phe His Leu
        115                 120                 125             
Glu Asn Ser Gly Trp Gln Lys Ile Asn Asn Phe Ser Ala Asp Ile Lys
    130                 135                 140                 
Asp Ser Lys Ala Tyr Phe His Leu Leu Asn Gln Ile Ala Pro Lys Gly
145                 150                 155                 160 
Gln Lys Glu Gly Glu Pro Arg Ile Asp Ile Asn Met Ser Gly Phe Asn
                165                 170                 175     
Glu Thr Asp Asp Leu Lys Arg Ala Glu Ser Met Leu Gln Gln Ala Asp
            180                 185                 190         
Lys Leu Gly Cys Arg Gln Phe Val Thr Pro Ala Asp Val Val Ser Gly
        195                 200                 205             
Asn Pro Lys Leu Asn Leu Ala Phe Val Ala Asn Leu Phe Asn Lys Tyr
    210                 215                 220                 
Pro Ala Leu Thr Lys Pro Glu Asn Gln Asp Ile Asp Trp Thr Leu Leu
225                 230                 235                 240 
Glu Gly Glu Thr Arg Glu Glu Arg Thr Phe Arg Asn Trp Met Asn Ser
                245                 250                 255     
Leu Gly Val Asn Pro His Val Asn His Leu Tyr Ala Asp Leu Gln Asp
            260                 265                 270         
Ala Leu Val Ile Leu Gln Leu Tyr Glu Arg Ile Lys Val Pro Val Asp
        275                 280                 285             
Trp Ser Lys Val Asn Lys Pro Pro Tyr Pro Lys Leu Gly Ala Asn Met
    290                 295                 300                 
Lys Lys Leu Glu Asn Cys Asn Tyr Ala Val Glu Leu Gly Lys His Pro
305                 310                 315                 320 
Ala Lys Phe Ser Leu Val Gly Ile Gly Gly Gln Asp Leu Asn Asp Gly
                325                 330                 335     
Asn Gln Thr Leu Thr Leu Ala Leu Val Trp Gln Leu Met Arg Arg Tyr
            340                 345                 350         
Thr Leu Asn Val Leu Glu Asp Leu Gly Asp Gly Gln Lys Ala Asn Asp
        355                 360                 365             
Asp Ile Ile Val Asn Trp Val Asn Arg Thr Leu Ser Glu Ala Gly Lys
    370                 375                 380                 
Ser Thr Ser Ile Gln Ser Phe Lys Asp Lys Thr Ile Ser Ser Ser Leu
385                 390                 395                 400 
Ala Val Val Asp Leu Ile Asp Ala Ile Gln Pro Gly Cys Ile Asn Tyr
                405                 410                 415     
Asp Leu Val Lys Ser Gly Asn Leu Thr Glu Asp Asp Lys His Asn Asn
            420                 425                 430         
Ala Lys Tyr Ala Val Ser Met Ala Arg Arg Ile Gly Ala Arg Val Tyr
        435                 440                 445             
Ala Leu Pro Glu Asp Leu Val Glu Val Lys Pro Lys Met Val Met Thr
    450                 455                 460                 
Val Phe Ala Cys Leu Met Gly Arg Gly Met Lys Arg Val
465                 470                 475         


<210> 1634
<211> 2321
<212> PRT
<213> Homo sapiens

<400> 1634
Met Gly Pro Gly Ala Arg Gly Arg Arg Arg Arg Arg Arg Pro Met Ser
 1               5                  10                  15      
Pro Pro Pro Pro Pro Pro Pro Val Arg Ala Leu Pro Leu Leu Leu Leu
            20                  25                  30          
Leu Ala Gly Pro Gly Ala Ala Ala Pro Pro Cys Leu Asp Gly Ser Pro
        35                  40                  45              
Cys Ala Asn Gly Gly Arg Cys Thr Gln Leu Pro Ser Arg Glu Ala Ala
    50                  55                  60                  
Cys Leu Cys Pro Pro Gly Trp Val Gly Glu Arg Cys Gln Leu Glu Asp
65                  70                  75                  80  
Pro Cys His Ser Gly Pro Cys Ala Gly Arg Gly Val Cys Gln Ser Ser
                85                  90                  95      
Val Val Ala Gly Thr Ala Arg Phe Ser Cys Arg Cys Pro Arg Gly Phe
            100                 105                 110         
Arg Gly Pro Asp Cys Ser Leu Pro Asp Pro Cys Leu Ser Ser Pro Cys
        115                 120                 125             
Ala His Gly Ala Arg Cys Ser Val Gly Pro Asp Gly Arg Phe Leu Cys
    130                 135                 140                 
Ser Cys Pro Pro Gly Tyr Gln Gly Arg Ser Cys Arg Ser Asp Val Asp
145                 150                 155                 160 
Glu Cys Arg Val Gly Glu Pro Cys Arg His Gly Gly Thr Cys Leu Asn
                165                 170                 175     
Thr Pro Gly Ser Phe Arg Cys Gln Cys Pro Ala Gly Tyr Thr Gly Pro
            180                 185                 190         
Leu Cys Glu Asn Pro Ala Val Pro Cys Ala Pro Ser Pro Cys Arg Asn
        195                 200                 205             
Gly Gly Thr Cys Arg Gln Ser Gly Asp Leu Thr Tyr Asp Cys Ala Cys
    210                 215                 220                 
Leu Pro Gly Phe Glu Gly Gln Asn Cys Glu Val Asn Val Asp Asp Cys
225                 230                 235                 240 
Pro Gly His Arg Cys Leu Asn Gly Gly Thr Cys Val Asp Gly Val Asn
                245                 250                 255     
Thr Tyr Asn Cys Gln Cys Pro Pro Glu Trp Thr Gly Gln Phe Cys Thr
            260                 265                 270         
Glu Asp Val Asp Glu Cys Gln Leu Gln Pro Asn Ala Cys His Asn Gly
        275                 280                 285             
Gly Thr Cys Phe Asn Thr Leu Gly Gly His Ser Cys Val Cys Val Asn
    290                 295                 300                 
Gly Trp Thr Gly Glu Ser Cys Ser Gln Asn Ile Asp Asp Cys Ala Thr
305                 310                 315                 320 
Ala Val Cys Phe His Gly Ala Thr Cys His Asp Arg Val Ala Ser Phe
                325                 330                 335     
Tyr Cys Ala Cys Pro Met Gly Lys Thr Gly Leu Leu Cys His Leu Asp
            340                 345                 350         
Asp Ala Cys Val Ser Asn Pro Cys His Glu Asp Ala Ile Cys Asp Thr
        355                 360                 365             
Asn Pro Val Asn Gly Arg Ala Ile Cys Thr Cys Pro Pro Gly Phe Thr
    370                 375                 380                 
Gly Gly Ala Cys Asp Gln Asp Val Asp Glu Cys Ser Ile Gly Ala Asn
385                 390                 395                 400 
Pro Cys Glu His Leu Gly Arg Cys Val Asn Thr Gln Gly Ser Phe Leu
                405                 410                 415     
Cys Gln Cys Gly Arg Gly Tyr Thr Gly Pro Arg Cys Glu Thr Asp Val
            420                 425                 430         
Asn Glu Cys Leu Ser Gly Pro Cys Arg Asn Gln Ala Thr Cys Leu Asp
        435                 440                 445             
Arg Ile Gly Gln Phe Thr Cys Ile Cys Met Ala Gly Phe Thr Gly Thr
    450                 455                 460                 
Tyr Cys Glu Val Asp Ile Asp Glu Cys Gln Ser Ser Pro Cys Val Asn
465                 470                 475                 480 
Gly Gly Val Cys Lys Asp Arg Val Asn Gly Phe Ser Cys Thr Cys Pro
                485                 490                 495     
Ser Gly Phe Ser Gly Ser Thr Cys Gln Leu Asp Val Asp Glu Cys Ala
            500                 505                 510         
Ser Thr Pro Cys Arg Asn Gly Ala Lys Cys Val Asp Gln Pro Asp Gly
        515                 520                 525             
Tyr Glu Cys Arg Cys Ala Glu Gly Phe Glu Gly Thr Leu Cys Asp Arg
    530                 535                 540                 
Asn Val Asp Asp Cys Ser Pro Asp Pro Cys His His Gly Arg Cys Val
545                 550                 555                 560 
Asp Gly Ile Ala Ser Phe Ser Cys Ala Cys Ala Pro Gly Tyr Thr Gly
                565                 570                 575     
Thr Arg Cys Glu Ser Gln Val Asp Glu Cys Arg Ser Gln Pro Cys Arg
            580                 585                 590         
His Gly Gly Lys Cys Leu Asp Leu Val Asp Lys Tyr Leu Cys Arg Cys
        595                 600                 605             
Pro Ser Gly Thr Thr Gly Val Asn Cys Glu Val Asn Ile Asp Asp Cys
    610                 615                 620                 
Ala Ser Asn Pro Cys Thr Phe Gly Val Cys Arg Asp Gly Ile Asn Arg
625                 630                 635                 640 
Tyr Asp Cys Val Cys Gln Pro Gly Phe Thr Gly Pro Leu Cys Asn Val
                645                 650                 655     
Glu Ile Asn Glu Cys Ala Ser Ser Pro Cys Gly Glu Gly Gly Ser Cys
            660                 665                 670         
Val Asp Gly Glu Asn Gly Phe Arg Cys Leu Cys Pro Pro Gly Ser Leu
        675                 680                 685             
Pro Pro Leu Cys Leu Pro Pro Ser His Pro Cys Ala His Glu Pro Cys
    690                 695                 700                 
Ser His Gly Ile Cys Tyr Asp Ala Pro Gly Gly Phe Arg Cys Val Cys
705                 710                 715                 720 
Glu Pro Gly Trp Ser Gly Pro Arg Cys Ser Gln Ser Leu Ala Arg Asp
                725                 730                 735     
Ala Cys Glu Ser Gln Pro Cys Arg Ala Gly Gly Thr Cys Ser Ser Asp
            740                 745                 750         
Gly Met Gly Phe His Cys Thr Cys Pro Pro Gly Val Gln Gly Arg Gln
        755                 760                 765             
Cys Glu Leu Leu Ser Pro Cys Thr Pro Asn Pro Cys Glu His Gly Gly
    770                 775                 780                 
Arg Cys Glu Ser Ala Pro Gly Gln Leu Pro Val Cys Ser Cys Pro Gln
785                 790                 795                 800 
Gly Trp Gln Gly Pro Arg Cys Gln Gln Asp Val Asp Glu Cys Ala Gly
                805                 810                 815     
Pro Ala Pro Cys Gly Pro His Gly Ile Cys Thr Asn Leu Ala Gly Ser
            820                 825                 830         
Phe Ser Cys Thr Cys His Gly Gly Tyr Thr Gly Pro Ser Cys Asp Gln
        835                 840                 845             
Asp Ile Asn Asp Cys Asp Pro Asn Pro Cys Leu Asn Gly Gly Ser Cys
    850                 855                 860                 
Gln Asp Gly Val Gly Ser Phe Ser Cys Ser Cys Leu Pro Gly Phe Ala
865                 870                 875                 880 
Gly Pro Arg Cys Ala Arg Asp Val Asp Glu Cys Leu Ser Asn Pro Cys
                885                 890                 895     
Gly Pro Gly Thr Cys Thr Asp His Val Ala Ser Phe Thr Cys Thr Cys
            900                 905                 910         
Pro Pro Gly Tyr Gly Gly Phe His Cys Glu Gln Asp Leu Pro Asp Cys
        915                 920                 925             
Ser Pro Ser Ser Cys Phe Asn Gly Gly Thr Cys Val Asp Gly Val Asn
    930                 935                 940                 
Ser Phe Ser Cys Leu Cys Arg Pro Gly Tyr Thr Gly Ala His Cys Gln
945                 950                 955                 960 
His Glu Ala Asp Pro Cys Leu Ser Arg Pro Cys Leu His Gly Gly Val
                965                 970                 975     
Cys Ser Ala Ala His Pro Gly Phe Arg Cys Thr Cys Leu Glu Ser Phe
            980                 985                 990         
Thr Gly Pro Gln Cys Gln Thr Leu Val Asp Trp Cys Ser Arg Gln Pro
        995                 1000                1005            
Cys Gln Asn Gly Gly Arg Cys Val Gln Thr Gly Ala Tyr Cys Leu Cys
    1010                1015                1020                
Pro Pro Gly Trp Ser Gly Arg Leu Cys Asp Ile Arg Ser Leu Pro Cys
1025                1030                1035                1040
Arg Glu Ala Ala Ala Gln Ile Gly Val Arg Leu Glu Gln Leu Cys Gln
                1045                1050                1055    
Ala Gly Gly Gln Cys Val Asp Glu Asp Ser Ser His Tyr Cys Val Cys
            1060                1065                1070        
Pro Glu Gly Arg Thr Gly Ser His Cys Glu Gln Glu Val Asp Pro Cys
        1075                1080                1085            
Leu Ala Gln Pro Cys Gln His Gly Gly Thr Cys Arg Gly Tyr Met Gly
    1090                1095                1100                
Gly Tyr Met Cys Glu Cys Leu Pro Gly Tyr Asn Gly Asp Asn Cys Glu
1105                1110                1115                1120
Asp Asp Val Asp Glu Cys Ala Ser Gln Pro Cys Gln His Gly Gly Ser
                1125                1130                1135    
Cys Ile Asp Leu Val Ala Arg Tyr Leu Cys Ser Cys Pro Pro Gly Thr
            1140                1145                1150        
Leu Gly Val Leu Cys Glu Ile Asn Glu Asp Asp Cys Gly Pro Gly Pro
        1155                1160                1165            
Pro Leu Asp Ser Gly Pro Arg Cys Leu His Asn Gly Thr Cys Val Asp
    1170                1175                1180                
Leu Val Gly Gly Phe Arg Cys Thr Cys Pro Pro Gly Tyr Thr Gly Leu
1185                1190                1195                1200
Arg Cys Glu Ala Asp Ile Asn Glu Cys Arg Ser Gly Ala Cys His Ala
                1205                1210                1215    
Ala His Thr Arg Asp Cys Leu Gln Asp Pro Gly Gly Gly Phe Arg Cys
            1220                1225                1230        
Leu Cys His Ala Gly Phe Ser Gly Pro Arg Cys Gln Thr Val Leu Ser
        1235                1240                1245            
Pro Cys Glu Ser Gln Pro Cys Gln His Gly Gly Gln Cys Arg Pro Ser
    1250                1255                1260                
Pro Gly Pro Gly Gly Gly Leu Thr Phe Thr Cys His Cys Ala Gln Pro
1265                1270                1275                1280
Phe Trp Gly Pro Arg Cys Glu Arg Val Ala Arg Ser Cys Arg Glu Leu
                1285                1290                1295    
Gln Cys Pro Val Gly Val Pro Cys Gln Gln Thr Pro Arg Gly Pro Arg
            1300                1305                1310        
Cys Ala Cys Pro Pro Gly Leu Ser Gly Pro Ser Cys Arg Ser Phe Pro
        1315                1320                1325            
Gly Ser Pro Pro Gly Ala Ser Asn Ala Ser Cys Ala Ala Ala Pro Cys
    1330                1335                1340                
Leu His Gly Gly Ser Cys Arg Pro Ala Pro Leu Ala Pro Phe Phe Arg
1345                1350                1355                1360
Cys Ala Cys Ala Gln Gly Trp Thr Gly Pro Arg Cys Glu Ala Pro Ala
                1365                1370                1375    
Ala Ala Pro Glu Val Ser Glu Glu Pro Arg Cys Pro Arg Ala Ala Cys
            1380                1385                1390        
Gln Ala Lys Arg Gly Asp Gln Arg Cys Asp Arg Glu Cys Asn Ser Pro
        1395                1400                1405            
Gly Cys Gly Trp Asp Gly Gly Asp Cys Ser Leu Ser Val Gly Asp Pro
    1410                1415                1420                
Trp Arg Gln Cys Glu Ala Leu Gln Cys Trp Arg Leu Phe Asn Asn Ser
1425                1430                1435                1440
Arg Cys Asp Pro Ala Cys Ser Ser Pro Ala Cys Leu Tyr Asp Asn Phe
                1445                1450                1455    
Asp Cys His Ala Gly Gly Arg Glu Arg Thr Cys Asn Pro Val Tyr Glu
            1460                1465                1470        
Lys Tyr Cys Ala Asp His Phe Ala Asp Gly Arg Cys Asp Gln Gly Cys
        1475                1480                1485            
Asn Thr Glu Glu Cys Gly Trp Asp Gly Leu Asp Cys Ala Ser Glu Val
    1490                1495                1500                
Pro Ala Leu Leu Ala Arg Gly Val Leu Val Leu Thr Val Leu Leu Pro
1505                1510                1515                1520
Pro Glu Glu Leu Leu Arg Ser Ser Ala Asp Phe Leu Gln Arg Leu Ser
                1525                1530                1535    
Ala Ile Leu Arg Thr Ser Leu Arg Phe Arg Leu Asp Ala His Gly Gln
            1540                1545                1550        
Ala Met Val Phe Pro Tyr His Arg Pro Ser Pro Gly Ser Glu Pro Arg
        1555                1560                1565            
Ala Arg Arg Glu Leu Ala Pro Glu Val Ile Gly Ser Val Val Met Leu
    1570                1575                1580                
Glu Ile Asp Asn Arg Leu Cys Leu Gln Ser Pro Glu Asn Asp His Cys
1585                1590                1595                1600
Phe Pro Asp Ala Gln Ser Ala Ala Asp Tyr Leu Gly Ala Leu Ser Ala
                1605                1610                1615    
Val Glu Arg Leu Asp Phe Pro Tyr Pro Leu Arg Asp Val Arg Gly Glu
            1620                1625                1630        
Pro Leu Glu Pro Pro Glu Pro Ser Val Pro Leu Leu Pro Leu Leu Val
        1635                1640                1645            
Ala Gly Ala Val Leu Leu Leu Val Ile Leu Val Leu Gly Val Met Val
    1650                1655                1660                
Ala Arg Arg Lys Arg Glu His Ser Thr Leu Trp Phe Pro Glu Gly Phe
1665                1670                1675                1680
Ser Leu His Lys Asp Val Ala Ser Gly His Lys Gly Arg Arg Glu Pro
                1685                1690                1695    
Val Gly Gln Asp Ala Leu Gly Met Lys Asn Met Ala Lys Gly Glu Ser
            1700                1705                1710        
Leu Met Gly Glu Val Ala Thr Asp Trp Met Asp Thr Glu Cys Pro Glu
        1715                1720                1725            
Ala Lys Arg Leu Lys Val Glu Glu Pro Gly Met Gly Ala Glu Glu Ala
    1730                1735                1740                
Val Asp Cys Arg Gln Trp Thr Gln His His Leu Val Ala Ala Asp Ile
1745                1750                1755                1760
Arg Val Ala Pro Ala Met Ala Leu Thr Pro Pro Gln Gly Asp Ala Asp
                1765                1770                1775    
Ala Asp Gly Met Asp Val Asn Val Arg Gly Pro Asp Gly Phe Thr Pro
            1780                1785                1790        
Leu Met Leu Ala Ser Phe Cys Gly Gly Ala Leu Glu Pro Met Pro Thr
        1795                1800                1805            
Glu Glu Asp Glu Ala Asp Asp Thr Ser Ala Ser Ile Ile Ser Asp Leu
    1810                1815                1820                
Ile Cys Gln Gly Ala Gln Leu Gly Ala Arg Thr Asp Arg Thr Gly Glu
1825                1830                1835                1840
Thr Ala Leu His Leu Ala Ala Arg Tyr Ala Arg Ala Asp Ala Ala Lys
                1845                1850                1855    
Arg Leu Leu Asp Ala Gly Ala Asp Thr Asn Ala Gln Asp His Ser Gly
            1860                1865                1870        
Arg Thr Pro Leu His Thr Ala Val Thr Ala Asp Ala Gln Gly Val Phe
        1875                1880                1885            
Gln Ile Leu Ile Arg Asn Arg Ser Thr Asp Leu Asp Ala Arg Met Ala
    1890                1895                1900                
Asp Gly Ser Thr Ala Leu Ile Leu Ala Ala Arg Leu Ala Val Glu Gly
1905                1910                1915                1920
Met Val Glu Glu Leu Ile Ala Ser His Ala Asp Val Asn Ala Val Asp
                1925                1930                1935    
Glu Leu Gly Lys Ser Ala Leu His Trp Ala Ala Ala Val Asn Asn Val
            1940                1945                1950        
Glu Ala Thr Leu Ala Leu Leu Lys Asn Gly Ala Asn Lys Asp Met Gln
        1955                1960                1965            
Asp Ser Lys Glu Glu Thr Pro Leu Phe Leu Ala Ala Arg Glu Gly Ser
    1970                1975                1980                
Tyr Glu Ala Ala Lys Leu Leu Leu Asp His Phe Ala Asn Arg Glu Ile
1985                1990                1995                2000
Thr Asp His Leu Asp Arg Leu Pro Arg Asp Val Ala Gln Glu Arg Leu
                2005                2010                2015    
His Gln Asp Ile Val Arg Leu Leu Asp Gln Pro Ser Gly Pro Arg Ser
            2020                2025                2030        
Pro Pro Gly Pro His Gly Leu Gly Pro Leu Leu Cys Pro Pro Gly Ala
        2035                2040                2045            
Phe Leu Pro Gly Leu Lys Ala Ala Gln Ser Gly Ser Lys Lys Ser Arg
    2050                2055                2060                
Arg Pro Pro Gly Lys Ala Gly Leu Gly Pro Gln Gly Pro Arg Gly Arg
2065                2070                2075                2080
Gly Lys Lys Leu Thr Leu Ala Cys Pro Gly Pro Leu Ala Asp Ser Ser
                2085                2090                2095    
Val Thr Leu Ser Pro Val Asp Ser Leu Asp Ser Pro Arg Pro Phe Gly
            2100                2105                2110        
Gly Pro Pro Ala Ser Pro Gly Gly Phe Pro Leu Glu Gly Pro Tyr Ala
        2115                2120                2125            
Ala Ala Thr Ala Thr Ala Val Ser Leu Ala Gln Leu Gly Gly Pro Gly
    2130                2135                2140                
Arg Ala Gly Leu Gly Arg Gln Pro Pro Gly Gly Cys Val Leu Ser Leu
2145                2150                2155                2160
Gly Leu Leu Asn Pro Val Ala Val Pro Leu Asp Trp Ala Arg Leu Pro
                2165                2170                2175    
Pro Pro Ala Pro Pro Gly Pro Ser Phe Leu Leu Pro Leu Ala Pro Gly
            2180                2185                2190        
Pro Gln Leu Leu Asn Pro Gly Thr Pro Val Ser Pro Gln Glu Arg Pro
        2195                2200                2205            
Pro Pro Tyr Leu Ala Val Pro Gly His Gly Glu Glu Tyr Pro Ala Ala
    2210                2215                2220                
Gly Ala His Ser Ser Pro Pro Lys Ala Arg Phe Leu Arg Val Pro Ser
2225                2230                2235                2240
Glu His Pro Tyr Leu Thr Pro Ser Pro Glu Ser Pro Glu His Trp Ala
                2245                2250                2255    
Ser Pro Ser Pro Pro Ser Leu Ser Asp Trp Ser Glu Ser Thr Pro Ser
            2260                2265                2270        
Pro Ala Thr Ala Thr Gly Ala Met Ala Thr Thr Thr Gly Ala Leu Pro
        2275                2280                2285            
Ala Gln Pro Leu Pro Leu Ser Val Pro Ser Ser Leu Ala Gln Ala Gln
    2290                2295                2300                
Thr Gln Leu Gly Pro Gln Pro Glu Val Thr Pro Lys Arg Gln Val Leu
2305                2310                2315                2320
Ala
    


<210> 1635
<211> 1583
<212> PRT
<213> Homo sapiens

<400> 1635
Met Lys Gln Glu Val Glu Asp Ser Val Thr Lys Met Gly Asp Ala His
 1               5                  10                  15      
Lys Glu Leu Glu Gln Ser His Ile Asn Tyr Val Lys Glu Ile Glu Asn
            20                  25                  30          
Leu Lys Asn Glu Leu Met Ala Val Arg Ser Lys Tyr Ser Glu Asp Lys
        35                  40                  45              
Ala Asn Leu Gln Lys Gln Leu Glu Glu Ala Met Asn Thr Gln Leu Glu
    50                  55                  60                  
Leu Ser Glu Gln Leu Lys Phe Gln Asn Asn Ser Glu Asp Asn Val Lys
65                  70                  75                  80  
Lys Leu Gln Glu Glu Ile Glu Lys Ile Arg Pro Gly Phe Glu Glu Gln
                85                  90                  95      
Ile Leu Tyr Leu Gln Lys Gln Leu Asp Ala Thr Thr Asp Glu Lys Lys
            100                 105                 110         
Glu Thr Val Thr Gln Leu Gln Asn Ile Ile Glu Ala Asn Ser Gln His
        115                 120                 125             
Tyr Gln Lys Asn Ile Asn Ser Leu Gln Glu Glu Leu Leu Gln Leu Lys
    130                 135                 140                 
Ala Ile His Gln Glu Glu Val Lys Glu Leu Met Cys Gln Ile Glu Ala
145                 150                 155                 160 
Ser Ala Lys Glu His Glu Ala Glu Ile Asn Lys Leu Asn Glu Leu Lys
                165                 170                 175     
Glu Asn Leu Val Lys Gln Cys Glu Ala Ser Glu Lys Asn Ile Gln Lys
            180                 185                 190         
Lys Tyr Glu Cys Glu Leu Glu Asn Leu Arg Lys Ala Thr Ser Asn Ala
        195                 200                 205             
Asn Gln Asp Asn Gln Ile Cys Ser Ile Leu Leu Gln Glu Asn Thr Phe
    210                 215                 220                 
Val Glu Gln Val Val Asn Glu Lys Val Lys His Leu Glu Asp Thr Leu
225                 230                 235                 240 
Lys Glu Leu Glu Ser Gln His Ser Ile Leu Lys Asp Glu Val Thr Tyr
                245                 250                 255     
Met Asn Asn Leu Lys Leu Lys Leu Glu Met Asp Ala Gln His Ile Lys
            260                 265                 270         
Asp Glu Phe Phe His Glu Arg Glu Asp Leu Glu Phe Lys Ile Asn Glu
        275                 280                 285             
Leu Leu Leu Ala Lys Glu Glu Gln Gly Cys Val Ile Glu Lys Leu Lys
    290                 295                 300                 
Ser Glu Leu Ala Gly Leu Asn Lys Gln Phe Cys Tyr Thr Val Glu Gln
305                 310                 315                 320 
His Asn Arg Glu Val Gln Ser Leu Lys Glu Gln His Gln Lys Glu Ile
                325                 330                 335     
Ser Glu Leu Asn Glu Thr Phe Leu Ser Asp Ser Glu Lys Glu Lys Leu
            340                 345                 350         
Thr Leu Met Phe Glu Ile Gln Gly Leu Lys Glu Gln Cys Glu Asn Leu
        355                 360                 365             
Gln Gln Glu Lys Gln Glu Ala Ile Leu Asn Tyr Glu Ser Leu Arg Glu
    370                 375                 380                 
Ile Met Glu Ile Leu Gln Thr Glu Leu Gly Glu Ser Ala Gly Lys Ile
385                 390                 395                 400 
Ser Gln Glu Phe Glu Ser Met Lys Gln Gln Gln Ala Ser Asp Val His
                405                 410                 415     
Glu Leu Gln Gln Lys Leu Arg Thr Ala Phe Thr Glu Lys Asp Ala Leu
            420                 425                 430         
Leu Glu Thr Val Asn Arg Leu Gln Gly Glu Asn Glu Lys Leu Leu Ser
        435                 440                 445             
Gln Gln Glu Leu Val Pro Glu Leu Glu Asn Thr Ile Lys Asn Leu Gln
    450                 455                 460                 
Glu Lys Asn Gly Val Tyr Leu Leu Ser Leu Ser Gln Arg Asp Thr Met
465                 470                 475                 480 
Leu Lys Glu Leu Glu Gly Lys Ile Asn Ser Leu Thr Glu Glu Lys Asp
                485                 490                 495     
Asp Phe Ile Asn Lys Leu Lys Asn Ser His Glu Glu Met Asp Asn Phe
            500                 505                 510         
His Lys Lys Cys Glu Arg Glu Glu Arg Leu Ile Leu Glu Leu Gly Lys
        515                 520                 525             
Lys Val Glu Gln Thr Ile Gln Tyr Asn Ser Glu Leu Glu Gln Lys Val
    530                 535                 540                 
Asn Glu Leu Thr Gly Gly Leu Glu Glu Thr Leu Lys Glu Lys Asp Gln
545                 550                 555                 560 
Asn Asp Gln Lys Leu Glu Lys Leu Met Val Gln Met Lys Val Leu Ser
                565                 570                 575     
Glu Asp Lys Glu Val Leu Ser Ala Glu Val Lys Ser Leu Tyr Glu Glu
            580                 585                 590         
Asn Asn Lys Leu Ser Ser Glu Lys Lys Gln Leu Ser Arg Asp Leu Glu
        595                 600                 605             
Val Phe Leu Ser Gln Lys Glu Asp Val Ile Leu Lys Glu His Ile Thr
    610                 615                 620                 
Gln Leu Glu Lys Lys Leu Gln Leu Met Val Glu Glu Gln Asp Asn Leu
625                 630                 635                 640 
Asn Lys Leu Leu Glu Asn Glu Gln Val Gln Lys Leu Phe Val Lys Thr
                645                 650                 655     
Gln Leu Tyr Gly Phe Leu Lys Glu Met Gly Ser Glu Val Ser Glu Asp
            660                 665                 670         
Ser Glu Glu Lys Asp Val Val Asn Val Leu Gln Ala Val Gly Glu Ser
        675                 680                 685             
Leu Ala Lys Ile Asn Glu Glu Lys Cys Asn Leu Ala Phe Gln Arg Asp
    690                 695                 700                 
Glu Lys Val Leu Glu Leu Glu Lys Glu Ile Lys Cys Leu Gln Glu Glu
705                 710                 715                 720 
Ser Val Val Gln Cys Glu Glu Leu Lys Ser Leu Leu Arg Asp Tyr Glu
                725                 730                 735     
Gln Glu Lys Val Leu Leu Arg Lys Glu Leu Glu Glu Ile Gln Ser Glu
            740                 745                 750         
Lys Glu Ala Leu Gln Ser Asp Leu Leu Glu Met Lys Asn Ala Asn Glu
        755                 760                 765             
Lys Thr Arg Leu Glu Asn Gln Asn Leu Leu Ile Gln Val Glu Glu Val
    770                 775                 780                 
Ser Gln Thr Cys Ser Lys Ser Glu Ile His Asn Glu Lys Glu Lys Cys
785                 790                 795                 800 
Phe Ile Lys Glu His Glu Asn Leu Lys Pro Leu Leu Glu Gln Lys Glu
                805                 810                 815     
Leu Arg Asp Arg Arg Ala Glu Leu Ile Leu Leu Lys Asp Ser Leu Ala
            820                 825                 830         
Lys Ser Pro Ser Val Lys Asn Asp Pro Leu Ser Ser Val Lys Glu Leu
        835                 840                 845             
Glu Glu Lys Ile Glu Asn Leu Glu Lys Glu Cys Lys Glu Lys Glu Glu
    850                 855                 860                 
Lys Ile Asn Lys Ile Lys Leu Val Ala Val Lys Ala Lys Lys Glu Leu
865                 870                 875                 880 
Asp Ser Ser Arg Lys Glu Thr Gln Thr Val Lys Glu Glu Leu Glu Ser
                885                 890                 895     
Leu Arg Ser Glu Lys Asp Gln Leu Ser Ala Ser Met Arg Asp Leu Ile
            900                 905                 910         
Gln Gly Ala Glu Ser Tyr Lys Asn Leu Leu Leu Glu Tyr Glu Lys Gln
        915                 920                 925             
Ser Glu Gln Leu Asp Val Glu Lys Glu Arg Ala Asn Asn Phe Glu His
    930                 935                 940                 
Arg Ile Glu Asp Leu Thr Arg Gln Leu Arg Asn Ser Thr Leu Gln Cys
945                 950                 955                 960 
Glu Thr Ile Asn Ser Asp Asn Glu Asp Leu Leu Ala Arg Ile Glu Thr
                965                 970                 975     
Leu Gln Ser Asn Ala Lys Leu Leu Glu Val Gln Ile Leu Glu Val Gln
            980                 985                 990         
Arg Ala Lys Ala Met Val Asp Lys Glu Leu Glu Ala Glu Lys Leu Gln
        995                 1000                1005            
Lys Glu Gln Lys Ile Lys Glu His Ala Thr Thr Val Asn Glu Leu Glu
    1010                1015                1020                
Glu Leu Gln Val Gln Leu Gln Lys Gln Lys Lys Gln Leu Gln Lys Thr
1025                1030                1035                1040
Met Gln Glu Leu Glu Leu Val Lys Lys Asp Ala Gln Gln Thr Thr Leu
                1045                1050                1055    
Met Asn Met Glu Ile Ala Asp Tyr Glu Arg Leu Met Lys Glu Leu Asn
            1060                1065                1070        
Gln Lys Leu Thr Asn Lys Asn Asn Lys Ile Glu Asp Leu Glu Gln Glu
        1075                1080                1085            
Ile Lys Ile Gln Lys Gln Lys Gln Glu Thr Leu Gln Glu Glu Ile Thr
    1090                1095                1100                
Ser Leu Gln Ser Ser Val Gln Gln Tyr Glu Glu Lys Asn Thr Lys Ile
1105                1110                1115                1120
Lys Gln Leu Leu Val Lys Thr Lys Lys Glu Leu Ala Asp Ser Lys Gln
                1125                1130                1135    
Ala Glu Thr Asp His Leu Ile Leu Gln Ala Ser Leu Lys Gly Glu Leu
            1140                1145                1150        
Glu Ala Ser Gln Gln Gln Val Glu Val Tyr Lys Ile Gln Leu Ala Glu
        1155                1160                1165            
Ile Thr Ser Glu Lys His Lys Ile His Glu His Leu Lys Thr Ser Ala
    1170                1175                1180                
Glu Gln His Gln Arg Thr Leu Ser Ala Tyr Gln Gln Arg Val Thr Ala
1185                1190                1195                1200
Leu Gln Glu Glu Cys Arg Ala Ala Lys Ala Glu Gln Ala Thr Val Thr
                1205                1210                1215    
Ser Glu Phe Glu Ser Tyr Lys Val Arg Val His Asn Val Leu Lys Gln
            1220                1225                1230        
Gln Lys Asn Lys Ser Met Ser Gln Ala Glu Thr Glu Gly Ala Lys Gln
        1235                1240                1245            
Glu Arg Glu His Leu Glu Met Leu Ile Asp Gln Leu Lys Ile Lys Leu
    1250                1255                1260                
Gln Asp Ser Gln Asn Asn Leu Gln Ile Asn Val Ser Glu Leu Gln Thr
1265                1270                1275                1280
Leu Gln Ser Glu His Asp Thr Leu Leu Glu Arg His Asn Lys Met Leu
                1285                1290                1295    
Gln Glu Thr Val Ser Lys Glu Ala Glu Leu Arg Glu Lys Leu Cys Ser
            1300                1305                1310        
Ile Gln Ser Glu Asn Met Met Met Lys Ser Glu His Thr Gln Thr Val
        1315                1320                1325            
Ser Gln Leu Thr Ser Gln Asn Glu Val Leu Arg Asn Ser Phe Arg Asp
    1330                1335                1340                
Gln Val Arg His Leu Gln Glu Glu His Arg Lys Thr Val Glu Thr Leu
1345                1350                1355                1360
Gln Gln Gln Leu Ser Lys Met Glu Ala Gln Leu Phe Gln Leu Lys Asn
                1365                1370                1375    
Glu Pro Thr Thr Arg Ser Pro Val Ser Ser Gln Gln Ser Leu Lys Asn
            1380                1385                1390        
Leu Arg Glu Arg Arg Asn Thr Asp Leu Pro Leu Leu Asp Met His Thr
        1395                1400                1405            
Val Thr Arg Glu Glu Gly Glu Gly Met Glu Thr Thr Asp Thr Glu Ser
    1410                1415                1420                
Val Ser Ser Ala Ser Thr Tyr Thr Gln Ser Leu Glu Gln Leu Leu Asn
1425                1430                1435                1440
Ser Pro Glu Thr Lys Leu Glu Pro Pro Leu Trp His Ala Glu Phe Thr
                1445                1450                1455    
Lys Glu Glu Leu Val Gln Lys Leu Ser Ser Thr Thr Lys Ser Ala Asp
            1460                1465                1470        
His Leu Asn Gly Leu Leu Arg Glu Thr Glu Ala Thr Asn Ala Ile Leu
        1475                1480                1485            
Met Glu Gln Ile Lys Leu Leu Lys Ser Glu Ile Arg Arg Leu Glu Arg
    1490                1495                1500                
Asn Gln Glu Arg Glu Lys Ser Ala Ala Asn Leu Glu Tyr Leu Lys Asn
1505                1510                1515                1520
Val Leu Leu Gln Phe Ile Phe Leu Lys Pro Gly Ser Glu Arg Glu Arg
                1525                1530                1535    
Leu Leu Pro Val Ile Asn Thr Met Leu Gln Leu Ser Pro Glu Glu Lys
            1540                1545                1550        
Gly Lys Leu Ala Ala Val Ala Gln Gly Glu Glu Glu Asn Ala Ser Arg
        1555                1560                1565            
Ser Ser Gly Trp Ala Ser Tyr Leu His Ser Trp Ser Gly Leu Arg
    1570                1575                1580            


<210> 1636
<211> 157
<212> PRT
<213> Homo sapiens

<400> 1636
Met Ala Ala Cys Met Lys Ser Val Thr Lys Gln Gly Ala Glu Leu Ser
 1               5                  10                  15      
Asn Glu Glu Arg Asn Leu Leu Ser Val Ala Tyr Lys Asn Val Val Gly
            20                  25                  30          
Ala Arg Lys Ser Ser Trp Arg Val Val Ser Ser Ile Glu Gln Lys Thr
        35                  40                  45              
Glu Gly Ala Glu Lys Lys Gln Gln Met Ala Arg Glu His Arg Glu Lys
    50                  55                  60                  
Ile Glu Thr Glu Leu Arg Asp Ile Cys Asn Asp Val Leu Ser Leu Leu
65                  70                  75                  80  
Glu Lys Phe Leu Ile Pro Asn Ala Ser Gln Ala Glu Ser Lys Val Phe
                85                  90                  95      
Tyr Leu Lys Met Lys Gly Asp Tyr Tyr Arg Tyr Leu Thr Glu Val Thr
            100                 105                 110         
Ala Gly Asp Asp Lys Ile Gly Ile Val Asp Gln Ser Gln Gln Ala Tyr
        115                 120                 125             
Gln Glu Ala Phe Glu Ile Ser Lys Lys Glu Met Gln Pro Thr His Pro
    130                 135                 140                 
Val Arg Leu Gly Leu Ala Leu Asn Phe Cys Val Leu Leu
145                 150                 155         


<210> 1637
<211> 301
<212> PRT
<213> Homo sapiens

<400> 1637
Met Glu Pro Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
 1               5                  10                  15      
Gln Gln Gln Lys Gln Pro His Leu Ala Pro Leu Gln Met Asp Ala Arg
            20                  25                  30          
Glu Lys Gln Gly Gln Gln Met Arg Glu Ala Gln Phe Leu Tyr Ala Gln
        35                  40                  45              
Lys Leu Val Thr Gln Pro Thr Leu Phe Ser Ala Thr Ala Gly Arg Pro
    50                  55                  60                  
Ser Gly Ser Thr Pro Leu Gly Pro Leu Ala Arg Val Pro Pro Thr Ala
65                  70                  75                  80  
Ala Val Ala Gln Val Phe Glu Arg Gly Asn Met Asn Ser Glu Pro Glu
                85                  90                  95      
Glu Glu Asp Gly Gly Leu Glu Asp Glu Asp Gly Asp Asp Glu Val Ala
            100                 105                 110         
Glu Val Ala Glu Lys Glu Thr Gln Ala Ala Ser Lys Tyr Phe His Val
        115                 120                 125             
Gln Lys Val Ala Arg Gln Asp Pro Arg Val Ala Pro Met Ser Asn Leu
    130                 135                 140                 
Leu Pro Ala Pro Gly Leu Pro Pro His Gly Gln Gln Ala Lys Glu Asp
145                 150                 155                 160 
His Thr Lys Asp Ala Ser Lys Ala Ser Ser Ser Val Ser Thr Ala Gly
                165                 170                 175     
Gln Leu Asn Trp Asn Leu Asp Glu Gln Leu Lys Gln Asn Gly Gly Leu
            180                 185                 190         
Ala Trp Ser Asp Asp Ala Asp Gly Gly Arg Gly Arg Glu Ile Ser Arg
        195                 200                 205             
Asp Phe Ala Lys Leu Tyr Glu Leu Asp Gly Asp Pro Glu Arg Lys Glu
    210                 215                 220                 
Phe Leu Asp Asp Leu Phe Val Phe Met Gln Lys Arg Arg Thr Pro Ile
225                 230                 235                 240 
Asn Arg Ile Pro Ile Met Ala Lys Gln Ile Leu Asp Leu Tyr Met Leu
                245                 250                 255     
Tyr Lys Leu Val Thr Glu Lys Gly Gly Leu Val Glu Ile Ile Asn Lys
            260                 265                 270         
Lys Ile Trp Arg Glu Ile Thr Lys Gly Leu Asn Leu Pro Thr Ser Ile
        275                 280                 285             
Thr Ser Ala Ala Phe Thr Leu Ser Ser Gly Arg Ser Thr
    290                 295                 300     


<210> 1638
<211> 386
<212> PRT
<213> Homo sapiens

<400> 1638
Met Gly Gln Arg Glu Met Trp Arg Leu Met Ser Arg Phe Asn Ala Phe
 1               5                  10                  15      
Lys Arg Thr Asn Thr Ile Leu His His Leu Arg Met Ser Lys His Thr
            20                  25                  30          
Asp Ala Ala Glu Glu Val Leu Leu Glu Lys Lys Gly Cys Thr Gly Val
        35                  40                  45              
Ile Thr Leu Asn Arg Pro Lys Phe Leu Asn Ala Leu Thr Leu Asn Met
    50                  55                  60                  
Ile Arg Gln Ile Tyr Pro Gln Leu Lys Lys Trp Glu Gln Asp Pro Glu
65                  70                  75                  80  
Thr Phe Leu Ile Ile Ile Lys Gly Ala Gly Gly Lys Ala Phe Cys Ala
                85                  90                  95      
Gly Gly Asp Ile Arg Val Ile Ser Glu Ala Glu Lys Ala Lys Gln Lys
            100                 105                 110         
Ile Ala Pro Val Phe Phe Arg Glu Glu Tyr Met Leu Asn Asn Ala Val
        115                 120                 125             
Gly Ser Cys Gln Lys Pro Tyr Val Ala Leu Ile His Gly Ile Thr Met
    130                 135                 140                 
Gly Gly Gly Val Gly Leu Ser Val His Gly Gln Phe Arg Val Ala Thr
145                 150                 155                 160 
Glu Lys Cys Leu Phe Ala Met Pro Glu Thr Ala Ile Gly Leu Phe Pro
                165                 170                 175     
Asp Val Gly Gly Gly Tyr Phe Leu Pro Arg Leu Gln Gly Lys Leu Gly
            180                 185                 190         
Tyr Phe Leu Ala Leu Thr Gly Phe Arg Leu Lys Gly Arg Asp Val Tyr
        195                 200                 205             
Arg Ala Gly Ile Ala Thr His Phe Val Asp Ser Glu Lys Leu Ala Met
    210                 215                 220                 
Leu Glu Glu Asp Leu Leu Ala Leu Lys Ser Pro Ser Lys Glu Asn Ile
225                 230                 235                 240 
Ala Ser Val Leu Glu Asn Tyr His Thr Glu Ser Lys Ile Asp Arg Asp
                245                 250                 255     
Lys Ser Phe Ile Leu Glu Glu His Met Asp Lys Ile Asn Ser Cys Phe
            260                 265                 270         
Ser Ala Asn Thr Val Glu Glu Ile Ile Glu Asn Leu Gln Gln Asp Gly
        275                 280                 285             
Ser Ser Phe Ala Leu Glu Gln Leu Lys Val Ile Asn Lys Met Ser Pro
    290                 295                 300                 
Thr Ser Leu Lys Ile Thr Leu Arg Gln Leu Met Glu Gly Ser Ser Lys
305                 310                 315                 320 
Thr Leu Gln Glu Val Leu Thr Met Glu Tyr Arg Leu Ser Gln Ala Cys
                325                 330                 335     
Met Arg Gly His Asp Phe His Glu Gly Val Arg Ala Val Leu Ile Asp
            340                 345                 350         
Lys Asp Gln Ser Pro Lys Trp Lys Pro Ala Asp Leu Lys Glu Val Thr
        355                 360                 365             
Glu Glu Asp Leu Asn Asn His Phe Lys Ser Leu Gly Ser Ser Asp Leu
    370                 375                 380                 
Lys Phe
385     


<210> 1639
<211> 261
<212> PRT
<213> Homo sapiens

<400> 1639
Met Ser Gly Ala Leu Asp Val Leu Gln Met Lys Glu Glu Asp Val Leu
 1               5                  10                  15      
Lys Phe Leu Ala Ala Gly Thr His Leu Gly Gly Thr Asn Leu Asp Phe
            20                  25                  30          
Gln Met Glu Gln Tyr Ile Tyr Lys Arg Lys Ser Asp Gly Ile Tyr Ile
        35                  40                  45              
Ile Asn Leu Lys Arg Thr Trp Glu Lys Leu Leu Leu Ala Ala Arg Ala
    50                  55                  60                  
Ile Val Ala Ile Glu Asn Pro Ala Asp Val Ser Val Ile Ser Ser Arg
65                  70                  75                  80  
Asn Thr Gly Gln Arg Ala Val Leu Lys Phe Ala Ala Ala Thr Gly Ala
                85                  90                  95      
Thr Pro Ile Ala Gly Arg Phe Thr Pro Gly Thr Phe Ala Asn Gln Ile
            100                 105                 110         
Gln Ala Ala Phe Arg Glu Pro Arg Leu Leu Val Val Thr Asp Pro Arg
        115                 120                 125             
Ala Asp His Gln Pro Leu Met Glu Ala Ser Tyr Val Asn Leu Pro Thr
    130                 135                 140                 
Ile Ala Leu Cys Asn Thr Asp Ser Pro Leu His Tyr Val Asp Ile Ala
145                 150                 155                 160 
Ile Pro Cys Asn Asn Lys Gly Ala His Ser Val Gly Leu Met Trp Trp
                165                 170                 175     
Met Leu Ala Arg Glu Val Leu Arg Met Arg Gly Thr Ile Ser Cys Glu
            180                 185                 190         
His Pro Trp Glu Val Met Pro Asp Leu Tyr Phe Tyr Arg Asp Pro Glu
        195                 200                 205             
Glu Ile Glu Arg Glu Glu Gln Ala Ala Ala Glu Lys Ala Val Thr Lys
    210                 215                 220                 
Glu Glu Phe Gln Gly Glu Trp Thr Ala Pro Ala Pro Glu Phe Thr Val
225                 230                 235                 240 
Thr Gln Pro Glu Val Ala Asp Trp Ser Glu Gly Val Gln Val Pro Ser
                245                 250                 255     
Val Pro Ile Pro Tyr
            260     


<210> 1640
<211> 192
<212> PRT
<213> Homo sapiens

<400> 1640
Met Gly Phe Gly Asp Leu Lys Ser Pro Ala Gly Leu Gln Val Leu Asn
 1               5                  10                  15      
Asp Tyr Leu Val Asp Lys Ser Tyr Ile Glu Gly Tyr Val Pro Ser Gln
            20                  25                  30          
Ala Asp Val Ala Ile Phe Glu Ala Val Ser Gly Pro Gln Pro Ala Gly
        35                  40                  45              
Leu Cys His Ala Leu Arg Trp Tyr Asn His Val Lys Ser Tyr Glu Lys
    50                  55                  60                  
Glu Lys Ala Ser Leu Pro Gly Val Lys Lys Ala Leu Gly Lys Tyr Gly
65                  70                  75                  80  
Pro Ala Asn Val Glu Asp Ala Thr Gly Ser Gly Gly Thr Asp Ser Lys
                85                  90                  95      
Asp Asp Asp Asp Ile Asp Leu Phe Gly Ser Asp Asp Glu Glu Glu Ser
            100                 105                 110         
Glu Glu Ala Lys Arg Leu Arg Glu Glu Ser Leu Ala Gln Tyr Glu Ser
        115                 120                 125             
Lys Leu Ala Lys Asn Pro Ala Leu Val Ala Lys Ser Ser Ile Leu Leu
    130                 135                 140                 
Asn Val Lys Pro Trp Asp Lys Glu Thr Asp Leu Ala Lys Leu Glu Glu
145                 150                 155                 160 
Cys Val Arg Ser Ile Gln Ala Asp Gly Leu Val Trp Gly Ser Ser Lys
                165                 170                 175     
Leu Val Pro Val Gly Tyr Arg Ile Lys Lys Pro Asn Thr Val Cys Ser
            180                 185                 190         


<210> 1641
<211> 408
<212> PRT
<213> Homo sapiens

<400> 1641
Met Asn Ala Glu Glu Asp Ser Glu Glu Met Pro Ser Leu Leu Thr Ser
 1               5                  10                  15      
Thr Val Gln Val Ala Ser Asp Asn Leu Ile Pro Gln Ile Arg Asp Lys
            20                  25                  30          
Glu Asp Pro Gln Glu Met Pro His Ser Pro Leu Gly Ser Met Pro Glu
        35                  40                  45              
Ile Arg Asp Asn Ser Pro Glu Pro Asn Asp Pro Glu Glu Pro Gln Glu
    50                  55                  60                  
Val Ser Ser Thr Pro Ser Asp Lys Lys Gly Lys Lys Arg Lys Arg Cys
65                  70                  75                  80  
Ile Trp Ser Thr Pro Lys Arg Arg His Lys Lys Lys Ser Leu Pro Gly
                85                  90                  95      
Gly Thr Ala Ser Ser Arg His Gly Ile Gln Lys Lys Leu Lys Arg Val
            100                 105                 110         
Asp Gln Val Pro Gln Lys Lys Asp Asp Ser Thr Cys Asn Ser Thr Val
        115                 120                 125             
Glu Thr Arg Ala Gln Lys Ala Arg Thr Glu Cys Ala Arg Lys Ser Arg
    130                 135                 140                 
Ser Glu Glu Ile Ile Asp Gly Thr Ser Glu Met Asn Glu Gly Lys Arg
145                 150                 155                 160 
Ser Gln Lys Thr Pro Ser Thr Pro Arg Arg Val Thr Gln Gly Ala Ala
                165                 170                 175     
Ser Pro Gly His Gly Ile Gln Glu Lys Leu Gln Val Val Asp Lys Val
            180                 185                 190         
Thr Gln Arg Lys Asp Asp Ser Thr Trp Asn Ser Glu Val Met Met Arg
        195                 200                 205             
Val Gln Lys Ala Arg Thr Lys Cys Ala Arg Lys Ser Arg Leu Lys Glu
    210                 215                 220                 
Lys Lys Lys Glu Lys Asp Ile Cys Ser Ser Ser Lys Arg Arg Phe Gln
225                 230                 235                 240 
Lys Asn Ile His Arg Arg Gly Lys Pro Lys Ser Asp Thr Val Asp Phe
                245                 250                 255     
His Cys Ser Lys Leu Pro Val Thr Cys Gly Glu Ala Lys Gly Ile Leu
            260                 265                 270         
Tyr Lys Lys Lys Met Lys His Gly Ser Ser Val Lys Cys Ile Arg Asn
        275                 280                 285             
Glu Asp Gly Thr Trp Leu Thr Pro Asn Glu Phe Glu Val Glu Gly Lys
    290                 295                 300                 
Gly Arg Asn Ala Lys Asn Trp Lys Arg Asn Ile Arg Cys Glu Gly Met
305                 310                 315                 320 
Thr Leu Gly Glu Leu Leu Lys Arg Lys Asn Ser Asp Glu Cys Glu Val
                325                 330                 335     
Cys Cys Gln Gly Gly Gln Leu Leu Cys Cys Gly Thr Cys Pro Arg Val
            340                 345                 350         
Phe His Glu Asp Cys His Ile Pro Pro Val Glu Ala Lys Arg Met Leu
        355                 360                 365             
Trp Ser Cys Thr Phe Cys Arg Met Lys Arg Ser Ser Gly Ser Gln Gln
    370                 375                 380                 
Cys His His Val Ser Lys Thr Leu Glu Arg Gln Met Gln Pro Gln Asp
385                 390                 395                 400 
Gln Leu Asn Val Ser Ser Ser Ser
                405             


<210> 1642
<211> 218
<212> PRT
<213> Homo sapiens

<400> 1642
Met Val Lys Tyr Phe Leu Gly Gln Ser Val Leu Arg Ser Ser Trp Asp
 1               5                  10                  15      
Gln Val Phe Ala Ala Phe Trp Gln Arg Tyr Pro Asn Pro Tyr Ser Lys
            20                  25                  30          
His Val Leu Thr Glu Asp Ile Val His Arg Glu Val Thr Pro Asp Gln
        35                  40                  45              
Lys Leu Leu Ser Arg Arg Leu Leu Thr Lys Thr Asn Arg Met Pro Arg
    50                  55                  60                  
Trp Ala Lys Gln Leu Phe Pro Ala Asn Val Ala His Ser Val Tyr Ile
65                  70                  75                  80  
Leu Glu Asp Ser Ile Val Asp Pro Gln Asn Gln Thr Met Thr Thr Phe
                85                  90                  95      
Thr Trp Asn Ile Asn His Ala Arg Leu Met Val Val Glu Glu Arg Cys
            100                 105                 110         
Val Tyr Cys Val Asn Ser Asp Asn Ser Gly Trp Thr Glu Ile Arg Arg
        115                 120                 125             
Glu Ala Trp Val Ser Ser Ser Leu Phe Gly Val Ser Arg Ala Val Gln
    130                 135                 140                 
Glu Phe Gly Leu Ala Gln Phe Lys Ser Asn Val Thr Lys Thr Met Lys
145                 150                 155                 160 
Gly Phe Glu Tyr Ile Leu Thr Lys Leu Gln Gly Glu Ala Pro Ser Lys
                165                 170                 175     
Thr Leu Glu Thr Ala Lys Glu Ala Lys Glu Lys Ala Glu Glu Thr Ala
            180                 185                 190         
Leu Ala Ala Thr Glu Lys Ala Lys Asp Leu Ala Ser Lys Ala Ala Thr
        195                 200                 205             
Lys Lys Gln Gln Gln Gln Gln Gln Phe Val
    210                 215             


<210> 1643
<211> 54
<212> PRT
<213> Homo sapiens

<400> 1643
Met Ala Leu Leu Leu Asn Ser Ser Trp Ser Thr Ser Pro Asp Leu Leu
 1               5                  10                  15      
Thr Ser Pro Ser Ser Phe Thr Lys Gln Lys Leu Gly Val Ala Gly Ser
            20                  25                  30          
Gln Pro Ser Ala His Thr Ala Arg Ser Lys Ala Ser Arg Lys Gln Gln
        35                  40                  45              
Met Arg Leu Ser Val Ser
    50                  


<210> 1644
<211> 161
<212> PRT
<213> Homo sapiens

<400> 1644
Met Ser Gly Lys Gln Lys Ser Lys Phe Asp Glu Met Ala Lys Ala Asp
 1               5                  10                  15      
Lys Val Arg Tyr Asp Arg Glu Met Lys Asp Tyr Gly Pro Ala Lys Gly
            20                  25                  30          
Gly Lys Lys Lys Lys Asp Pro Asn Ala Pro Lys Arg Pro Pro Ser Gly
        35                  40                  45              
Phe Phe Leu Phe Cys Ser Glu Phe His Pro Lys Ile Lys Ser Thr Asn
    50                  55                  60                  
Pro Gly Ile Ser Ile Gly Asp Val Ala Lys Asn Leu Ser Glu Met Trp
65                  70                  75                  80  
Asn Asn Leu Asn Asp Ser Glu Lys Gln Pro Tyr Ile Thr Lys Ala Ala
                85                  90                  95      
Lys Leu Lys Glu Lys Tyr Glu Lys Asp Val Ala Asp Tyr Lys Ser Lys
            100                 105                 110         
Gly Lys Phe Asp Gly Ala Lys Val Leu Leu Lys Leu Pro Gly Lys Arg
        115                 120                 125             
Trp Lys Arg Lys Arg Lys Arg Arg Arg Lys Lys Arg Arg Arg Arg Arg
    130                 135                 140                 
Met Arg Arg Arg Arg Asn Lys Glu Thr Val Tyr Arg Leu Leu Val Asn
145                 150                 155                 160 
Thr
    


<210> 1645
<211> 926
<212> PRT
<213> Homo sapiens

<400> 1645
Met Ser Arg Arg Arg Lys His Asp Asp Ser Pro Ser Pro Lys Lys Thr
 1               5                  10                  15      
Pro His Lys Thr Val Ala Ala Glu Glu Cys Gly Ser Val Val Glu Pro
            20                  25                  30          
Gly Arg Arg Arg Leu Arg Ser Ala Arg Gly Ser Trp Pro Cys Gly Ala
        35                  40                  45              
Arg Glu Gly Pro Pro Gly Pro Val Arg Gln Arg Glu Gln Pro Pro Thr
    50                  55                  60                  
Ala Ala Leu Cys Ser Lys Ser Asn Pro Glu Glu Arg Tyr Glu Thr Pro
65                  70                  75                  80  
Lys Arg Ala Leu Lys Met Asp Ser Leu Ser Ser Ser Phe Ser Ser Pro
                85                  90                  95      
Asn Asp Pro Asp Gly Gln Asn Asp Ile Phe Trp Asp Gln Asn Ser Pro
            100                 105                 110         
Leu Thr Lys Gln Leu Gly Lys Gly Arg Lys Lys Gln Ile Tyr Thr Thr
        115                 120                 125             
Asp Ser Asp Glu Ile Ser His Ile Val Asn Arg Ile Ala Pro Gln Asp
    130                 135                 140                 
Glu Lys Pro Thr Thr Asn Ser Met Leu Asp Met Trp Ile Gly Glu Thr
145                 150                 155                 160 
Ala Ile Pro Cys Thr Pro Ser Val Ala Lys Gly Lys Ser Arg Ala Lys
                165                 170                 175     
Ile Ser Cys Thr Lys Leu Lys Thr Gln Ser Gln Glu Glu Glu Leu Met
            180                 185                 190         
Lys Leu Ala Lys Gln Phe Asp Lys Asn Met Glu Glu Leu Asp Val Ile
        195                 200                 205             
Gln Glu Gln Asn Lys Arg Asn Tyr Asp Phe Thr Gln Met Ile Ser Glu
    210                 215                 220                 
Thr Glu Ile Leu Ser Asn Tyr Lys Asp Asn Ile Gln Met Trp Ser Leu
225                 230                 235                 240 
His Asn Ile Val Pro Glu Ile Asp Asn Ala Thr Lys Lys Pro Ile Lys
                245                 250                 255     
Gly Asn Thr Lys Ile Ser Val Ala Asn Asn Gln Asn Ser Ser Gln Lys
            260                 265                 270         
Pro Phe Asp Gln Ile Ala Glu Ala Ala Phe Asn Ala Ile Phe Asp Gly
        275                 280                 285             
Ser Thr Gln Lys Cys Ser Gly Gln Leu Ser Gln Glu Leu Pro Glu Ala
    290                 295                 300                 
Phe Trp Ser Thr Ser Asn Thr Thr Phe Val Lys Thr Asn Ala Leu Lys
305                 310                 315                 320 
Glu Glu Lys Ile Ile Thr Asn Glu Thr Leu Val Ile Glu Lys Leu Ser
                325                 330                 335     
Asn Lys Thr Pro Arg Ser Leu Ser Ser Gln Val Asp Thr Pro Ile Met
            340                 345                 350         
Thr Lys Ser Cys Val Thr Ser Cys Thr Lys Glu Pro Glu Thr Ser Asn
        355                 360                 365             
Lys Tyr Ile Asp Ala Phe Thr Thr Ser Asp Phe Glu Asp Asp Trp Glu
    370                 375                 380                 
Asn Leu Leu Gly Ser Glu Pro Phe Ala Met Gln Asn Ile Asp Met Pro
385                 390                 395                 400 
Glu Leu Phe Pro Ser Lys Thr Ala His Val Thr Asp Gln Lys Glu Ile
                405                 410                 415     
Cys Thr Phe Asn Ser Lys Thr Val Lys Asn Thr Ser Arg Ala Asn Thr
            420                 425                 430         
Ser Pro Asp Ala Arg Leu Gly Asp Ser Lys Val Leu Gln Asp Leu Ser
        435                 440                 445             
Ser Lys Thr Tyr Asp Arg Glu Leu Ile Asp Ala Glu Tyr Arg Phe Ser
    450                 455                 460                 
Pro Asn Ser Asn Lys Ser Asn Lys Leu Ser Thr Gly Asn Lys Met Lys
465                 470                 475                 480 
Phe Glu Asn Ser Ser Asn Lys Ile Val Ile Gln Asp Glu Ile Gln Asn
                485                 490                 495     
Cys Ile Val Thr Ser Asn Leu Thr Lys Ile Lys Glu Asp Ile Leu Thr
            500                 505                 510         
Asn Ser Thr Glu Ala Ser Glu Arg Lys Ser Ala Leu Asn Thr Arg Tyr
        515                 520                 525             
Ser Asn Glu Gln Lys Asn Lys Cys Ile Leu Asn Gln Ser Ile Lys Ala
    530                 535                 540                 
Pro Val Asn Thr Asp Leu Phe Gly Ser Ala Asn Leu Gly Ser Lys Thr
545                 550                 555                 560 
Ser Val Ser Asn Pro Asn Gln Thr Ser Ala Ser Lys Val Gly Ser Phe
                565                 570                 575     
Phe Asp Asp Trp Asn Asp Pro Ser Phe Ala Asn Glu Ile Ile Lys Ala
            580                 585                 590         
Cys His Gln Leu Asp Asn Thr Trp Glu Ala Asp Asp Val Asp Asp Asp
        595                 600                 605             
Leu Leu Tyr Gln Ala Cys Asp Asp Ile Glu Arg Leu Thr Gln Gln Gln
    610                 615                 620                 
Asp Ile Arg Lys Asp Ser Lys Thr Ser Glu Ser Ile Cys Glu Ile Asn
625                 630                 635                 640 
Asn Asn Ser Glu His Gly Ala Lys Leu Thr Gln Gln Gln Asp Ile Arg
                645                 650                 655     
Lys Asp Ser Lys Thr Ser Glu Ser Ile Cys Glu Ile Asn Asn Asn Ser
            660                 665                 670         
Glu His Gly Ala Lys Asn Met Phe Ala Ile Ser Lys Gln Gly Ser Asn
        675                 680                 685             
Leu Val Gln Ser Lys His Leu Asn Pro Gly Ser Ile Ser Val Gln Thr
    690                 695                 700                 
Ser Leu Thr Asn Ser Ser Gln Ile Asp Lys Pro Met Lys Met Glu Lys
705                 710                 715                 720 
Gly Glu Met Tyr Gly Asn Ser Pro Arg Phe Leu Gly Ala Thr Asn Leu
                725                 730                 735     
Thr Met Tyr Ser Lys Ile Ser Asn Cys Gln Ile Asn Asn Leu His Val
            740                 745                 750         
Ser Tyr Thr Asn Thr Asp Val Pro Ile Gln Val Asn Ser Ser Lys Leu
        755                 760                 765             
Val Leu Pro Gly Ser Ser Ser Leu Asn Val Thr Ser Asp His Met Asn
    770                 775                 780                 
Thr Glu Ile Thr Thr Tyr Lys Lys Lys Leu Ser Thr Asn Gln Pro Cys
785                 790                 795                 800 
His Lys Thr Val Thr Asp Glu Ala Gln Ser Asn Leu Asn Thr Thr Val
                805                 810                 815     
Gly Phe Ser Lys Phe Thr Phe Thr Arg Met Lys Asn Ser Gln Ile Leu
            820                 825                 830         
Ser Gln Phe Asn Gln Asn Cys Ile Thr Gly Ser Met Ser Asp Thr Lys
        835                 840                 845             
Ile Thr Gln Gly Val Glu Lys Lys Lys Gly Val Asn Pro Leu Leu Glu
    850                 855                 860                 
Glu Ala Val Gly Gln Gln Ser Leu Val Lys Leu Ser Glu Ser Leu Lys
865                 870                 875                 880 
Gln Ser Ser Lys Glu Glu Glu Glu Lys Asn Arg Lys Cys Ser Pro Glu
                885                 890                 895     
Glu Ile Gln Arg Lys Arg Gln Glu Ala Leu Val Arg Arg Met Ala Lys
            900                 905                 910         
Ala Arg Ala Ser Ser Val Asn Ala Ala Pro Thr Ser Phe Leu
        915                 920                 925     


<210> 1646
<211> 727
<212> PRT
<213> Homo sapiens

<400> 1646
Met Leu Arg Ile Pro Val Arg Lys Ala Leu Val Gly Leu Ser Lys Ser
 1               5                  10                  15      
Pro Lys Gly Cys Val Arg Thr Thr Ala Thr Ala Ala Ser Asn Leu Ile
            20                  25                  30          
Glu Val Phe Val Asp Gly Gln Ser Val Met Val Glu Pro Gly Thr Thr
        35                  40                  45              
Val Leu Gln Ala Cys Glu Lys Val Gly Met Gln Ile Pro Arg Phe Cys
    50                  55                  60                  
Tyr His Glu Arg Leu Ser Val Ala Gly Asn Cys Arg Met Cys Leu Val
65                  70                  75                  80  
Glu Ile Glu Lys Ala Pro Lys Val Val Ala Ala Cys Ala Met Pro Val
                85                  90                  95      
Met Lys Gly Trp Asn Ile Leu Thr Asn Ser Glu Lys Ser Lys Lys Ala
            100                 105                 110         
Arg Glu Gly Val Met Glu Phe Leu Leu Ala Asn His Pro Leu Asp Cys
        115                 120                 125             
Pro Ile Cys Asp Gln Gly Gly Glu Cys Asp Leu Gln Asp Gln Ser Met
    130                 135                 140                 
Met Phe Gly Asn Asp Arg Ser Arg Phe Leu Glu Gly Lys Arg Ala Val
145                 150                 155                 160 
Glu Asp Lys Asn Ile Gly Pro Leu Val Lys Thr Ile Met Thr Arg Cys
                165                 170                 175     
Ile Gln Cys Thr Arg Cys Ile Arg Phe Ala Ser Glu Ile Ala Gly Val
            180                 185                 190         
Asp Asp Leu Gly Thr Thr Gly Arg Gly Asn Asp Met Gln Val Gly Thr
        195                 200                 205             
Tyr Ile Glu Lys Met Phe Met Ser Glu Leu Ser Gly Asn Ile Ile Asp
    210                 215                 220                 
Ile Cys Pro Val Gly Ala Leu Thr Ser Lys Pro Tyr Ala Phe Thr Ala
225                 230                 235                 240 
Arg Pro Trp Glu Thr Arg Lys Thr Glu Ser Ile Asp Val Met Asp Ala
                245                 250                 255     
Val Gly Ser Asn Ile Val Val Ser Thr Arg Thr Gly Glu Val Met Arg
            260                 265                 270         
Ile Leu Pro Arg Met His Glu Asp Ile Asn Glu Glu Trp Ile Ser Asp
        275                 280                 285             
Lys Thr Arg Phe Ala Tyr Asp Gly Leu Lys Arg Gln Arg Leu Thr Glu
    290                 295                 300                 
Pro Met Val Arg Asn Glu Lys Gly Leu Leu Thr Tyr Thr Ser Trp Glu
305                 310                 315                 320 
Asp Ala Leu Ser Arg Val Ala Gly Met Leu Gln Ser Phe Gln Gly Lys
                325                 330                 335     
Asp Val Ala Ala Ile Ala Gly Gly Leu Val Asp Ala Glu Ala Leu Val
            340                 345                 350         
Ala Leu Lys Asp Leu Leu Asn Arg Val Asp Ser Asp Thr Leu Cys Thr
        355                 360                 365             
Glu Glu Val Phe Pro Thr Ala Gly Ala Gly Thr Asp Leu Arg Ser Asn
    370                 375                 380                 
Tyr Leu Leu Asn Thr Thr Ile Ala Gly Val Glu Glu Ala Asp Val Val
385                 390                 395                 400 
Leu Leu Val Gly Thr Asn Pro Arg Phe Glu Ala Pro Leu Phe Asn Ala
                405                 410                 415     
Arg Ile Arg Lys Ser Trp Leu His Asn Asp Leu Lys Val Ala Leu Ile
            420                 425                 430         
Gly Ser Pro Val Asp Leu Thr Tyr Thr Tyr Asp His Leu Gly Asp Ser
        435                 440                 445             
Pro Lys Ile Leu Gln Asp Ile Ala Ser Gly Ser His Pro Phe Ser Gln
    450                 455                 460                 
Val Leu Lys Glu Ala Lys Lys Pro Met Val Val Leu Gly Ser Ser Ala
465                 470                 475                 480 
Leu Gln Arg Asn Asp Gly Ala Ala Ile Leu Ala Ala Val Ser Ser Ile
                485                 490                 495     
Ala Gln Lys Ile Arg Met Thr Ser Gly Val Thr Gly Asp Trp Lys Val
            500                 505                 510         
Met Asn Ile Leu His Arg Ile Ala Ser Gln Val Ala Ala Leu Asp Leu
        515                 520                 525             
Gly Tyr Lys Pro Gly Val Glu Ala Ile Arg Lys Asn Pro Pro Lys Val
    530                 535                 540                 
Leu Phe Leu Leu Gly Ala Asp Gly Gly Cys Ile Thr Arg Gln Asp Leu
545                 550                 555                 560 
Pro Lys Asp Cys Phe Ile Ile Tyr Gln Gly His His Gly Asp Val Gly
                565                 570                 575     
Ala Pro Ile Ala Asp Val Ile Leu Pro Gly Ala Ala Tyr Thr Glu Lys
            580                 585                 590         
Ser Ala Thr Tyr Val Asn Thr Glu Gly Arg Ala Gln Gln Thr Lys Val
        595                 600                 605             
Ala Val Thr Pro Pro Gly Leu Ala Arg Glu Asp Trp Lys Ile Ile Arg
    610                 615                 620                 
Ala Leu Ser Glu Ile Ala Gly Met Thr Leu Pro Tyr Asp Thr Leu Asp
625                 630                 635                 640 
Gln Val Arg Asn Arg Leu Glu Glu Val Ser Pro Asn Leu Val Arg Tyr
                645                 650                 655     
Asp Asp Ile Glu Gly Ala Asn Tyr Phe Gln Gln Ala Asn Glu Leu Ser
            660                 665                 670         
Lys Leu Val Asn Gln Gln Leu Leu Ala Asp Pro Leu Val Pro Pro Gln
        675                 680                 685             
Leu Thr Ile Lys Asp Phe Tyr Met Thr Asp Ser Ile Ser Arg Ala Ser
    690                 695                 700                 
Gln Thr Met Ala Lys Cys Val Lys Ala Val Thr Glu Gly Ala Gln Ala
705                 710                 715                 720 
Val Glu Glu Pro Ser Ile Cys
                725         


<210> 1647
<211> 293
<212> PRT
<213> Homo sapiens

<400> 1647
Met Ala Thr His Gly Gln Thr Cys Ala Arg Pro Met Cys Ile Pro Pro
 1               5                  10                  15      
Ser Tyr Ala Asp Leu Gly Lys Ala Ala Arg Asp Ile Phe Asn Lys Gly
            20                  25                  30          
Phe Gly Phe Gly Leu Val Lys Leu Asp Val Lys Thr Lys Ser Cys Ser
        35                  40                  45              
Gly Val Glu Phe Ser Thr Ser Gly Ser Ser Asn Thr Asp Thr Gly Lys
    50                  55                  60                  
Val Thr Gly Thr Leu Glu Thr Lys Tyr Lys Trp Cys Glu Tyr Gly Leu
65                  70                  75                  80  
Thr Phe Thr Glu Lys Trp Asn Thr Asp Asn Thr Leu Gly Thr Glu Ile
                85                  90                  95      
Ala Ile Glu Asp Gln Ile Cys Gln Gly Leu Lys Leu Thr Phe Asp Thr
            100                 105                 110         
Thr Phe Ser Pro Asn Thr Gly Lys Lys Ser Gly Lys Ile Lys Ser Tyr
        115                 120                 125             
Lys Arg Glu Cys Ile Asn Leu Gly Cys Asp Val Asp Phe Asp Phe Ala
    130                 135                 140                 
Gly Pro Ala Ile His Gly Ser Ala Val Phe Gly Tyr Glu Gly Trp Leu
145                 150                 155                 160 
Ala Gly Tyr Gln Met Thr Phe Asp Ser Ala Lys Ser Lys Leu Thr Arg
                165                 170                 175     
Asn Asn Phe Ala Val Gly Tyr Arg Thr Gly Asp Phe Gln Leu His Thr
            180                 185                 190         
Asn Val Asn Asp Gly Thr Glu Phe Gly Gly Ser Ile Tyr Gln Lys Val
        195                 200                 205             
Cys Glu Asp Leu Asp Thr Ser Val Asn Leu Ala Trp Thr Ser Gly Thr
    210                 215                 220                 
Asn Cys Thr Arg Phe Gly Ile Ala Ala Lys Tyr Gln Leu Asp Pro Thr
225                 230                 235                 240 
Ala Ser Ile Ser Ala Lys Val Asn Asn Ser Ser Leu Ile Gly Val Gly
                245                 250                 255     
Tyr Thr Gln Thr Leu Arg Pro Gly Val Lys Leu Thr Leu Ser Ala Leu
            260                 265                 270         
Val Asp Gly Lys Ser Ile Asn Ala Gly Gly His Lys Val Gly Leu Ala
        275                 280                 285             
Leu Glu Leu Glu Ala
    290             


<210> 1648
<211> 173
<212> PRT
<213> Homo sapiens

<400> 1648
Met Ala Leu Arg Val Val Arg Ser Val Arg Ala Leu Leu Cys Thr Leu
 1               5                  10                  15      
Arg Ala Val Pro Ser Pro Ala Ala Pro Cys Pro Pro Arg Pro Trp Gln
            20                  25                  30          
Leu Gly Val Gly Ala Val Arg Thr Leu Arg Thr Gly Pro Ala Leu Leu
        35                  40                  45              
Ser Val Arg Lys Phe Thr Glu Lys His Glu Trp Val Thr Thr Glu Asn
    50                  55                  60                  
Gly Ile Gly Thr Val Gly Ile Ser Asn Phe Ala Gln Glu Ala Leu Gly
65                  70                  75                  80  
Asp Val Val Tyr Cys Ser Leu Pro Glu Val Gly Thr Lys Leu Asn Lys
                85                  90                  95      
Gln Asp Glu Phe Gly Ala Leu Glu Ser Val Lys Ala Ala Ser Glu Leu
            100                 105                 110         
Tyr Ser Pro Leu Ser Gly Glu Val Thr Glu Ile Asn Glu Ala Leu Ala
        115                 120                 125             
Glu Asn Pro Gly Leu Val Asn Lys Ser Cys Tyr Glu Asp Gly Trp Leu
    130                 135                 140                 
Ile Lys Met Thr Leu Ser Asn Pro Ser Glu Leu Asp Glu Leu Met Ser
145                 150                 155                 160 
Glu Glu Ala Tyr Glu Lys Tyr Ile Lys Ser Ile Glu Glu
                165                 170             


<210> 1649
<211> 375
<212> PRT
<213> Homo sapiens

<400> 1649
Met Ala Val Thr Glu Ala Ser Leu Leu Arg Gln Cys Pro Leu Leu Leu
 1               5                  10                  15      
Pro Gln Asn Arg Ser Lys Thr Val Tyr Glu Gly Phe Ile Ser Ala Gln
            20                  25                  30          
Gly Arg Asp Phe His Leu Arg Ile Val Leu Pro Glu Asp Leu Gln Leu
        35                  40                  45              
Lys Asn Ala Arg Leu Leu Cys Ser Trp Gln Leu Arg Thr Ile Leu Ser
    50                  55                  60                  
Gly Tyr His Arg Ile Val Gln Gln Arg Met Gln His Ser Pro Asp Leu
65                  70                  75                  80  
Met Ser Phe Met Met Glu Leu Lys Met Leu Leu Glu Val Ala Leu Lys
                85                  90                  95      
Asn Arg Gln Glu Leu Tyr Ala Leu Pro Pro Pro Pro Gln Phe Tyr Ser
            100                 105                 110         
Ser Leu Ile Glu Glu Ile Gly Thr Leu Gly Trp Asp Lys Leu Val Tyr
        115                 120                 125             
Ala Asp Thr Cys Phe Ser Thr Ile Lys Leu Lys Ala Glu Asp Ala Ser
    130                 135                 140                 
Gly Arg Glu His Leu Ile Thr Leu Lys Leu Lys Ala Lys Tyr Pro Ala
145                 150                 155                 160 
Glu Ser Pro Asp Tyr Phe Val Asp Phe Pro Val Pro Phe Cys Ala Ser
                165                 170                 175     
Trp Thr Pro Gln Ser Ser Leu Ile Ser Ile Tyr Ser Gln Phe Leu Ala
            180                 185                 190         
Ala Ile Glu Ser Leu Lys Ala Phe Trp Asp Val Met Asp Glu Ile Asp
        195                 200                 205             
Glu Lys Thr Trp Val Leu Glu Pro Glu Lys Pro Pro Arg Ser Ala Thr
    210                 215                 220                 
Ala Arg Arg Ile Ala Leu Gly Asn Asn Val Ser Ile Asn Ile Glu Val
225                 230                 235                 240 
Asp Pro Arg His Pro Thr Met Leu Pro Glu Cys Phe Phe Leu Gly Ala
                245                 250                 255     
Asp His Val Val Lys Pro Leu Gly Ile Lys Leu Ser Arg Asn Ile His
            260                 265                 270         
Leu Trp Asp Pro Glu Asn Ser Val Leu Gln Asn Leu Lys Asp Val Leu
        275                 280                 285             
Glu Ile Asp Phe Pro Ala Arg Ala Ile Leu Glu Lys Ser Asp Phe Thr
    290                 295                 300                 
Met Asp Cys Gly Ile Cys Tyr Ala Tyr Gln Leu Asp Gly Thr Ile Pro
305                 310                 315                 320 
Asp Gln Val Cys Asp Asn Ser Gln Cys Gly Gln Pro Phe His Gln Ile
                325                 330                 335     
Cys Leu Tyr Glu Trp Leu Arg Gly Leu Leu Thr Ser Arg Gln Ser Phe
            340                 345                 350         
Asn Ile Ile Phe Gly Glu Cys Pro Tyr Cys Ser Lys Pro Ile Thr Leu
        355                 360                 365             
Lys Met Ser Gly Arg Lys His
    370                 375 


<210> 1650
<211> 1222
<212> PRT
<213> Homo sapiens

<400> 1650
Met Ser Arg Gln Ser Thr Leu Tyr Ser Phe Phe Pro Lys Ser Pro Ala
 1               5                  10                  15      
Leu Ser Asp Ala Asn Lys Ala Ser Ala Arg Ala Ser Arg Glu Gly Gly
            20                  25                  30          
Arg Ala Ala Ala Ala Pro Gly Ala Ser Pro Ser Pro Gly Gly Asp Ala
        35                  40                  45              
Ala Trp Ser Glu Ala Gly Pro Gly Pro Arg Pro Leu Ala Arg Ser Ala
    50                  55                  60                  
Ser Pro Pro Lys Ala Lys Asn Leu Asn Gly Gly Leu Arg Arg Ser Val
65                  70                  75                  80  
Ala Pro Ala Ala Pro Thr Ser Cys Asp Phe Ser Pro Gly Asp Leu Val
                85                  90                  95      
Trp Ala Lys Met Glu Gly Tyr Pro Trp Trp Pro Cys Leu Val Tyr Asn
            100                 105                 110         
His Pro Phe Asp Gly Thr Phe Ile Arg Glu Lys Gly Lys Ser Val Arg
        115                 120                 125             
Val His Val Gln Phe Phe Asp Asp Ser Pro Thr Arg Gly Trp Val Ser
    130                 135                 140                 
Lys Arg Leu Leu Lys Pro Tyr Thr Gly Ser Lys Ser Lys Glu Ala Gln
145                 150                 155                 160 
Lys Gly Gly His Phe Tyr Ser Ala Lys Pro Glu Ile Leu Arg Ala Met
                165                 170                 175     
Gln Arg Ala Asp Glu Ala Leu Asn Lys Asp Lys Ile Lys Arg Leu Glu
            180                 185                 190         
Leu Ala Val Cys Asp Glu Pro Ser Glu Pro Glu Glu Glu Glu Glu Met
        195                 200                 205             
Glu Val Gly Thr Thr Tyr Val Thr Asp Lys Ser Glu Glu Asp Asn Glu
    210                 215                 220                 
Ile Glu Ser Glu Glu Glu Val Gln Pro Lys Thr Gln Gly Ser Arg Arg
225                 230                 235                 240 
Ser Ser Arg Gln Ile Lys Lys Arg Arg Val Ile Ser Asp Ser Glu Ser
                245                 250                 255     
Asp Ile Gly Gly Ser Asp Val Glu Phe Lys Pro Asp Thr Lys Glu Glu
            260                 265                 270         
Gly Ser Ser Asp Glu Ile Ser Ser Gly Val Gly Asp Ser Glu Ser Glu
        275                 280                 285             
Gly Leu Asn Ser Pro Val Lys Val Ala Arg Lys Arg Lys Arg Met Val
    290                 295                 300                 
Thr Gly Asn Gly Ser Leu Lys Arg Lys Ser Ser Arg Lys Glu Thr Pro
305                 310                 315                 320 
Ser Ala Thr Lys Gln Ala Thr Ser Ile Ser Ser Glu Thr Lys Asn Thr
                325                 330                 335     
Leu Arg Ala Phe Ser Ala Pro Gln Asn Ser Glu Ser Gln Ala His Val
            340                 345                 350         
Ser Gly Gly Gly Asp Asp Ser Ser Arg Pro Thr Val Trp Tyr His Glu
        355                 360                 365             
Thr Leu Glu Trp Leu Lys Glu Glu Lys Arg Arg Asp Glu His Arg Arg
    370                 375                 380                 
Arg Pro Asp His Pro Asp Phe Asp Ala Ser Thr Leu Tyr Val Pro Glu
385                 390                 395                 400 
Asp Phe Leu Asn Ser Cys Thr Pro Gly Met Arg Lys Trp Trp Gln Ile
                405                 410                 415     
Lys Ser Gln Asn Phe Asp Leu Val Ile Cys Tyr Lys Val Gly Lys Phe
            420                 425                 430         
Tyr Glu Leu Tyr His Met Asp Ala Leu Ile Gly Val Ser Glu Leu Gly
        435                 440                 445             
Leu Val Phe Met Lys Gly Asn Trp Ala His Ser Gly Phe Pro Glu Ile
    450                 455                 460                 
Ala Phe Gly Arg Tyr Ser Asp Ser Leu Val Gln Lys Gly Tyr Lys Val
465                 470                 475                 480 
Ala Arg Val Glu Gln Thr Glu Thr Pro Glu Met Met Glu Ala Arg Cys
                485                 490                 495     
Arg Lys Met Ala His Ile Ser Lys Tyr Asp Arg Val Val Arg Arg Glu
            500                 505                 510         
Ile Cys Arg Ile Ile Thr Lys Gly Thr Gln Thr Tyr Ser Val Leu Glu
        515                 520                 525             
Gly Asp Pro Ser Glu Asn Tyr Ser Lys Tyr Leu Leu Ser Leu Lys Glu
    530                 535                 540                 
Lys Glu Glu Asp Ser Ser Gly His Thr Arg Ala Tyr Gly Val Cys Phe
545                 550                 555                 560 
Val Asp Thr Ser Leu Gly Lys Phe Phe Ile Gly Gln Phe Ser Asp Asp
                565                 570                 575     
Arg His Cys Ser Arg Phe Arg Thr Leu Val Ala His Tyr Pro Pro Val
            580                 585                 590         
Gln Val Leu Phe Glu Lys Gly Asn Leu Ser Lys Glu Thr Lys Thr Ile
        595                 600                 605             
Leu Lys Ser Ser Leu Ser Cys Ser Leu Gln Glu Gly Leu Ile Pro Gly
    610                 615                 620                 
Ser Gln Phe Trp Asp Ala Ser Lys Thr Leu Arg Thr Leu Leu Glu Glu
625                 630                 635                 640 
Glu Tyr Phe Arg Glu Lys Leu Ser Asp Gly Ile Gly Val Met Leu Pro
                645                 650                 655     
Gln Val Leu Lys Gly Met Thr Ser Glu Ser Asp Ser Ile Gly Leu Thr
            660                 665                 670         
Pro Gly Glu Lys Ser Glu Leu Ala Leu Ser Ala Leu Gly Gly Cys Val
        675                 680                 685             
Phe Tyr Leu Lys Lys Cys Leu Ile Asp Gln Glu Leu Leu Ser Met Ala
    690                 695                 700                 
Asn Phe Glu Glu Tyr Ile Pro Leu Asp Ser Asp Thr Val Ser Thr Thr
705                 710                 715                 720 
Arg Ser Gly Ala Ile Phe Thr Lys Ala Tyr Gln Arg Met Val Leu Asp
                725                 730                 735     
Ala Val Thr Leu Asn Asn Leu Glu Ile Phe Leu Asn Gly Thr Asn Gly
            740                 745                 750         
Ser Thr Glu Gly Thr Leu Leu Glu Arg Val Asp Thr Cys His Thr Pro
        755                 760                 765             
Phe Gly Lys Arg Leu Leu Lys Gln Trp Leu Cys Ala Pro Leu Cys Asn
    770                 775                 780                 
His Tyr Ala Ile Asn Asp Arg Leu Asp Ala Ile Glu Asp Leu Met Val
785                 790                 795                 800 
Val Pro Asp Lys Ile Ser Glu Val Val Glu Leu Leu Lys Lys Leu Pro
                805                 810                 815     
Asp Leu Glu Arg Leu Leu Ser Lys Ile His Asn Val Gly Ser Pro Leu
            820                 825                 830         
Lys Ser Gln Asn His Pro Asp Ser Arg Ala Ile Met Tyr Glu Glu Thr
        835                 840                 845             
Thr Tyr Ser Lys Lys Lys Ile Ile Asp Phe Leu Ser Ala Leu Glu Gly
    850                 855                 860                 
Phe Lys Val Met Cys Lys Ile Ile Gly Ile Met Glu Glu Val Ala Asp
865                 870                 875                 880 
Gly Phe Lys Ser Lys Ile Leu Lys Gln Val Ile Ser Leu Gln Thr Lys
                885                 890                 895     
Asn Pro Glu Gly Arg Phe Pro Asp Leu Thr Val Glu Leu Asn Arg Trp
            900                 905                 910         
Asp Thr Ala Phe Asp His Glu Lys Ala Arg Lys Thr Gly Leu Ile Thr
        915                 920                 925             
Pro Lys Ala Gly Phe Asp Ser Asp Tyr Asp Gln Ala Leu Ala Asp Ile
    930                 935                 940                 
Arg Glu Asn Glu Gln Ser Leu Leu Glu Tyr Leu Glu Lys Gln Arg Asn
945                 950                 955                 960 
Arg Ile Gly Cys Arg Thr Ile Val Tyr Trp Gly Ile Gly Arg Asn Arg
                965                 970                 975     
Tyr Gln Leu Glu Ile Pro Glu Asn Phe Thr Thr Arg Asn Leu Pro Glu
            980                 985                 990         
Glu Tyr Glu Leu Lys Ser Thr Lys Lys Gly Cys Lys Arg Tyr Trp Thr
        995                 1000                1005            
Lys Thr Ile Glu Lys Lys Leu Ala Asn Leu Ile Asn Ala Glu Glu Arg
    1010                1015                1020                
Arg Asp Val Ser Leu Lys Asp Cys Met Arg Arg Leu Phe Tyr Asn Phe
1025                1030                1035                1040
Asp Lys Asn Tyr Lys Asp Trp Gln Ser Ala Val Glu Cys Ile Ala Val
                1045                1050                1055    
Leu Asp Val Leu Leu Cys Leu Ala Asn Tyr Ser Arg Gly Gly Asp Gly
            1060                1065                1070        
Pro Met Cys Arg Pro Val Ile Leu Leu Pro Glu Asp Thr Pro Pro Phe
        1075                1080                1085            
Leu Glu Leu Lys Gly Ser Arg His Pro Cys Ile Thr Lys Thr Phe Phe
    1090                1095                1100                
Gly Asp Asp Phe Ile Pro Asn Asp Ile Leu Ile Gly Cys Glu Glu Glu
1105                1110                1115                1120
Glu Gln Glu Asn Gly Lys Ala Tyr Cys Val Leu Val Thr Gly Pro Asn
                1125                1130                1135    
Met Gly Gly Lys Ser Thr Leu Met Arg Gln Ala Gly Leu Leu Ala Val
            1140                1145                1150        
Met Ala Gln Met Gly Cys Tyr Val Pro Ala Glu Val Cys Arg Leu Thr
        1155                1160                1165            
Pro Ile Asp Arg Val Phe Thr Arg Leu Gly Ala Ser Asp Arg Ile Met
    1170                1175                1180                
Ser Gly Glu Ser Thr Phe Phe Val Glu Leu Ser Glu Thr Ala Ser Ile
1185                1190                1195                1200
Leu Met His Ala Thr Ala His Ser Leu Val Leu Val Asp Glu Leu Gly
                1205                1210                1215    
Lys Arg Tyr Cys Asn Ile
            1220        


<210> 1651
<211> 114
<212> PRT
<213> Homo sapiens

<400> 1651
Met Tyr Tyr Lys Phe Ser Gly Phe Thr Gln Lys Leu Ala Gly Ala Trp
 1               5                  10                  15      
Ala Ser Glu Ala Tyr Ser Pro Gln Gly Leu Lys Pro Val Val Ser Thr
            20                  25                  30          
Glu Ala Pro Pro Ile Ile Phe Ala Thr Pro Thr Lys Leu Thr Ser Asp
        35                  40                  45              
Ser Thr Val Tyr Asp Tyr Ala Gly Lys Asn Lys Val Pro Glu Leu Gln
    50                  55                  60                  
Lys Phe Phe Gln Lys Ala Asp Gly Val Pro Val Tyr Leu Lys Arg Gly
65                  70                  75                  80  
Leu Pro Asp Gln Met Leu Tyr Arg Thr Thr Met Ala Leu Thr Val Gly
                85                  90                  95      
Gly Thr Ile Tyr Cys Leu Ile Ala Leu Tyr Met Ala Ser Gln Pro Lys
            100                 105                 110         
Asn Lys
        


<210> 1652
<211> 218
<212> PRT
<213> Homo sapiens

<400> 1652
Met Pro Met Thr Leu Gly Tyr Trp Asp Ile Arg Gly Leu Ala His Ala
 1               5                  10                  15      
Ile Arg Leu Leu Leu Glu Tyr Thr Asp Ser Ser Tyr Val Glu Lys Lys
            20                  25                  30          
Tyr Thr Leu Gly Asp Ala Pro Asp Tyr Asp Arg Ser Gln Trp Leu Asn
        35                  40                  45              
Glu Lys Phe Lys Leu Gly Leu Asp Phe Pro Asn Leu Pro Tyr Leu Ile
    50                  55                  60                  
Asp Gly Ala His Lys Ile Thr Gln Ser Asn Ala Ile Leu Arg Tyr Ile
65                  70                  75                  80  
Ala Arg Lys His Asn Leu Cys Gly Glu Thr Glu Glu Glu Lys Ile Arg
                85                  90                  95      
Val Asp Ile Leu Glu Asn Gln Val Met Asp Asn His Met Glu Leu Val
            100                 105                 110         
Arg Leu Cys Tyr Asp Pro Asp Phe Glu Lys Leu Lys Pro Lys Tyr Leu
        115                 120                 125             
Glu Glu Leu Pro Glu Lys Leu Lys Leu Tyr Ser Glu Phe Leu Gly Lys
    130                 135                 140                 
Arg Pro Trp Phe Ala Gly Asp Lys Ile Thr Phe Val Asp Phe Leu Ala
145                 150                 155                 160 
Tyr Asp Val Leu Asp Met Lys Arg Ile Phe Glu Pro Lys Cys Leu Asp
                165                 170                 175     
Ala Phe Leu Asn Leu Lys Asp Phe Ile Ser Arg Phe Glu Gly Leu Lys
            180                 185                 190         
Lys Ile Ser Ala Tyr Met Lys Ser Ser Gln Phe Leu Arg Gly Leu Leu
        195                 200                 205             
Phe Gly Lys Ser Ala Thr Trp Asn Ser Lys
    210                 215             


<210> 1653
<211> 497
<212> PRT
<213> Homo sapiens

<400> 1653
Met Ala Asp Pro Glu Val Val Val Ser Ser Cys Ser Ser His Glu Glu
 1               5                  10                  15      
Glu Asn Arg Cys Asn Phe Asn Gln Gln Thr Ser Pro Ser Glu Glu Leu
            20                  25                  30          
Leu Leu Glu Asp Gln Met Arg Arg Lys Leu Lys Phe Phe Phe Met Asn
        35                  40                  45              
Pro Cys Glu Lys Phe Trp Ala Arg Gly Arg Lys Pro Trp Lys Leu Ala
    50                  55                  60                  
Ile Gln Ile Leu Lys Ile Ala Met Val Thr Ile Gln Tyr Leu Gln Leu
65                  70                  75                  80  
Tyr Asn Val Ser Val Gly Asn His Ala Tyr Glu Asn Lys Gly Thr Lys
                85                  90                  95      
Gln Ser Ala Met Ala Ile Cys Gln His Phe Tyr Lys Arg Gly Asn Ile
            100                 105                 110         
Tyr Pro Gly Asn Asp Thr Phe Asp Ile Asp Pro Glu Ile Glu Thr Glu
        115                 120                 125             
Cys Phe Phe Val Glu Pro Asp Glu Pro Phe His Ile Gly Thr Pro Ala
    130                 135                 140                 
Glu Asn Lys Leu Asn Leu Thr Leu Asp Phe His Arg Leu Leu Thr Val
145                 150                 155                 160 
Glu Leu Gln Phe Lys Leu Lys Ala Ile Asn Leu Gln Thr Val Arg His
                165                 170                 175     
Gln Glu Leu Pro Asp Cys Tyr Asp Phe Thr Leu Thr Ile Thr Phe Asp
            180                 185                 190         
Asn Lys Ala His Ser Gly Arg Ile Lys Ile Ser Leu Asp Asn Asp Ile
        195                 200                 205             
Ser Ile Arg Glu Cys Lys Asp Trp His Val Ser Gly Ser Ile Gln Lys
    210                 215                 220                 
Asn Thr His Tyr Met Met Ile Phe Asp Ala Phe Val Ile Leu Thr Cys
225                 230                 235                 240 
Leu Val Ser Leu Ile Leu Cys Ile Arg Ser Val Ile Arg Gly Leu Gln
                245                 250                 255     
Leu Gln Gln Glu Phe Val Asn Phe Phe Leu Leu His Tyr Lys Lys Glu
            260                 265                 270         
Val Ser Val Ser Asp Gln Met Glu Phe Val Asn Gly Trp Tyr Ile Met
        275                 280                 285             
Ile Ile Ile Ser Asp Ile Leu Thr Ile Ile Gly Ser Ile Leu Lys Met
    290                 295                 300                 
Glu Ile Gln Ala Lys Ser Leu Thr Ser Tyr Asp Val Cys Ser Ile Leu
305                 310                 315                 320 
Leu Gly Thr Ser Thr Met Leu Val Trp Leu Gly Val Ile Arg Tyr Leu
                325                 330                 335     
Gly Phe Phe Ala Lys Tyr Asn Leu Leu Ile Leu Thr Leu Gln Ala Ala
            340                 345                 350         
Leu Pro Asn Val Ile Arg Phe Cys Cys Cys Ala Ala Met Ile Tyr Leu
        355                 360                 365             
Gly Tyr Cys Phe Cys Gly Trp Ile Val Leu Gly Pro Tyr His Asp Lys
    370                 375                 380                 
Phe Arg Ser Leu Asn Met Val Ser Glu Cys Leu Phe Ser Leu Ile Asn
385                 390                 395                 400 
Gly Asp Asp Met Phe Ala Thr Phe Ala Lys Met Gln Gln Lys Ser Tyr
                405                 410                 415     
Leu Val Trp Leu Phe Ser Arg Ile Tyr Leu Tyr Ser Phe Ile Ser Leu
            420                 425                 430         
Phe Ile Tyr Met Ile Leu Ser Leu Phe Ile Ala Leu Ile Thr Asp Thr
        435                 440                 445             
Tyr Glu Thr Ile Lys Gln Tyr Gln Gln Asp Gly Phe Pro Glu Thr Glu
    450                 455                 460                 
Leu Arg Thr Phe Ile Ser Glu Cys Lys Asp Leu Pro Asn Ser Gly Lys
465                 470                 475                 480 
Tyr Arg Leu Glu Asp Asp Pro Pro Val Ser Leu Phe Cys Cys Cys Lys
                485                 490                 495     
Lys
    


<210> 1654
<211> 352
<212> PRT
<213> Homo sapiens

<400> 1654
Met Thr Gly Thr His Leu His Arg Thr Ile Lys Thr Tyr Leu Gln Gln
 1               5                  10                  15      
Ile Gly Val Asp Met Asp Lys Ile His Gly Gln Ala Tyr Asp Ser Thr
            20                  25                  30          
Thr Asn Leu Lys Ile Lys Phe Asn Lys Ile Ala Ala Glu Phe Lys Lys
        35                  40                  45              
Glu Glu Pro Arg Ala Leu Tyr Ile His Cys Tyr Ala His Phe Leu Asp
    50                  55                  60                  
Leu Ser Ile Ile Arg Phe Cys Lys Glu Val Lys Glu Leu Arg Ser Ala
65                  70                  75                  80  
Leu Lys Thr Leu Ser Ser Leu Phe Asn Thr Ile Cys Met Ser Gly Glu
                85                  90                  95      
Met Leu Ala Asn Phe Arg Asn Ile Tyr Arg Leu Ser Gln Asn Lys Thr
            100                 105                 110         
Cys Lys Lys His Ile Ser Gln Ser Cys Trp Thr Val His Asp Arg Thr
        115                 120                 125             
Leu Leu Ser Val Ile Asp Ser Leu Pro Glu Ile Ile Glu Thr Leu Glu
    130                 135                 140                 
Val Ile Ala Ser His Ser Ser Asn Thr Ser Phe Ala Asp Glu Leu Ser
145                 150                 155                 160 
His Leu Leu Thr Leu Val Ser Lys Phe Glu Phe Val Phe Cys Leu Lys
                165                 170                 175     
Phe Leu Tyr Arg Val Leu Ser Val Thr Gly Ile Leu Ser Lys Glu Leu
            180                 185                 190         
Gln Asn Lys Thr Ile Asp Ile Phe Ser Leu Ser Ser Lys Ile Glu Ala
        195                 200                 205             
Ile Leu Glu Cys Leu Ser Ser Glu Arg Asn Asp Val Tyr Phe Lys Thr
    210                 215                 220                 
Ile Trp Asp Gly Thr Glu Glu Ile Cys Gln Lys Ile Thr Cys Lys Gly
225                 230                 235                 240 
Phe Lys Val Glu Lys Pro Ser Leu Gln Lys Arg Arg Lys Ile Gln Lys
                245                 250                 255     
Ser Val Asp Leu Gly Asn Ser Asp Met Phe Phe Pro Thr Ser Thr Glu
            260                 265                 270         
Glu Gln Tyr Lys Ile Asn Ile Tyr Tyr Gln Gly Leu Asp Thr Ile Leu
        275                 280                 285             
Gln Asn Leu Lys Leu Cys Phe Ser Glu Phe Asp Tyr Cys Lys Ile Lys
    290                 295                 300                 
Gln Ile Ser Glu Leu Leu Phe Lys Trp Asn Asp Pro Leu Asn Asp Thr
305                 310                 315                 320 
Thr Ala Lys His Gly Ser Gly His Phe Ile Ile Leu Asp Glu Asp Ile
                325                 330                 335     
Ile Pro Glu Leu Arg Phe Tyr Arg Pro His Ala His Leu Thr Leu Ser
            340                 345                 350         


<210> 1655
<211> 1042
<212> PRT
<213> Homo sapiens

<400> 1655
Met Ala Gln Lys Leu Val Gln Ala Glu Arg Glu Ala Gln Ala Ser Leu
 1               5                  10                  15      
Arg Glu Gln Arg Ala Ala His Glu Glu Asp Leu Gln Arg Leu Gln Arg
            20                  25                  30          
Glu Lys Glu Ala Ala Trp Arg Glu Leu Glu Ala Glu Arg Ala Gln Leu
        35                  40                  45              
Gln Ser Gln Leu Gln Arg Glu Gln Glu Glu Leu Leu Ala Arg Leu Glu
    50                  55                  60                  
Ala Glu Lys Glu Glu Leu Ser Glu Glu Ile Ala Ala Leu Gln Gln Glu
65                  70                  75                  80  
Arg Asp Glu Gly Leu Leu Leu Ala Glu Ser Glu Lys Gln Gln Ala Leu
                85                  90                  95      
Ser Leu Lys Glu Ser Glu Lys Thr Ala Leu Ser Glu Lys Leu Met Gly
            100                 105                 110         
Thr Arg His Ser Leu Ala Thr Ile Ser Leu Glu Met Glu Arg Gln Lys
        115                 120                 125             
Arg Asp Ala Gln Ser Arg Gln Glu Gln Asp Arg Ser Thr Val Asn Ala
    130                 135                 140                 
Leu Thr Ser Glu Leu Arg Asp Leu Arg Ala Gln Arg Glu Glu Ala Ala
145                 150                 155                 160 
Ala Ala His Ala Gln Glu Val Arg Arg Leu Gln Glu Gln Ala Arg Asp
                165                 170                 175     
Leu Gly Lys Gln Arg Asp Ser Cys Leu Arg Glu Ala Glu Glu Leu Arg
            180                 185                 190         
Thr Gln Leu Arg Leu Leu Glu Asp Ala Arg Asp Gly Leu Arg Arg Glu
        195                 200                 205             
Leu Leu Glu Ala Gln Arg Lys Leu Arg Glu Ser Gln Glu Gly Arg Glu
    210                 215                 220                 
Val Gln Arg Gln Glu Ala Gly Glu Leu Arg Arg Ser Leu Gly Glu Gly
225                 230                 235                 240 
Ala Lys Glu Arg Glu Ala Leu Arg Arg Ser Asn Glu Glu Leu Arg Ser
                245                 250                 255     
Ala Val Lys Lys Ala Glu Ser Glu Arg Ile Ser Leu Lys Leu Ala Asn
            260                 265                 270         
Glu Asp Lys Glu Gln Lys Leu Ala Leu Leu Glu Glu Ala Arg Thr Ala
        275                 280                 285             
Val Gly Lys Glu Ala Gly Glu Leu Arg Thr Gly Leu Gln Glu Val Glu
    290                 295                 300                 
Arg Ser Arg Leu Glu Ala Arg Arg Glu Leu Gln Glu Leu Arg Arg Gln
305                 310                 315                 320 
Met Lys Met Leu Asp Ser Glu Asn Thr Arg Leu Gly Arg Glu Leu Ala
                325                 330                 335     
Glu Leu Gln Gly Arg Leu Ala Leu Gly Glu Arg Ala Glu Lys Glu Ser
            340                 345                 350         
Arg Arg Glu Thr Leu Gly Leu Arg Gln Arg Leu Leu Lys Gly Glu Ala
        355                 360                 365             
Ser Leu Glu Val Met Arg Gln Glu Leu Gln Val Ala Gln Arg Lys Leu
    370                 375                 380                 
Gln Glu Gln Glu Gly Glu Phe Arg Thr Arg Glu Arg Arg Leu Leu Gly
385                 390                 395                 400 
Ser Leu Glu Glu Ala Arg Gly Thr Glu Lys Gln Gln Leu Asp His Ala
                405                 410                 415     
Arg Gly Leu Glu Leu Lys Leu Glu Ala Ala Arg Ala Glu Ala Ala Glu
            420                 425                 430         
Leu Gly Leu Arg Leu Ser Ala Ala Glu Gly Arg Ala Gln Gly Leu Glu
        435                 440                 445             
Ala Glu Leu Ala Arg Val Glu Val Gln Arg Arg Ala Ala Glu Ala Gln
    450                 455                 460                 
Leu Gly Gly Leu Arg Ser Ala Leu Arg Arg Gly Leu Gly Leu Gly Arg
465                 470                 475                 480 
Ala Pro Ser Pro Ala Pro Arg Pro Val Pro Gly Ser Pro Ala Arg Asp
                485                 490                 495     
Ala Pro Ala Glu Gly Ser Gly Glu Gly Leu Asn Ser Pro Ser Thr Leu
            500                 505                 510         
Glu Cys Ser Pro Gly Ser Gln Pro Pro Ser Pro Gly Pro Ala Thr Ser
        515                 520                 525             
Pro Ala Ser Pro Asp Leu Asp Pro Glu Ala Val Arg Gly Ala Leu Arg
    530                 535                 540                 
Glu Phe Leu Gln Glu Leu Arg Ser Ala Gln Arg Glu Arg Asp Glu Leu
545                 550                 555                 560 
Arg Thr Gln Thr Ser Ala Leu Asn Arg Gln Leu Ala Glu Met Glu Ala
                565                 570                 575     
Glu Arg Asp Ser Ala Thr Ser Arg Ala Arg Gln Leu Gln Lys Ala Val
            580                 585                 590         
Ala Glu Ser Glu Glu Ala Arg Arg Ser Val Asp Gly Arg Leu Ser Gly
        595                 600                 605             
Val Gln Ala Glu Leu Ala Leu Gln Glu Glu Ser Val Arg Arg Ser Glu
    610                 615                 620                 
Arg Glu Arg Arg Ala Thr Leu Asp Gln Val Ala Thr Leu Glu Arg Ser
625                 630                 635                 640 
Leu Gln Ala Thr Glu Ser Glu Leu Arg Ala Ser Gln Glu Lys Ile Ser
                645                 650                 655     
Lys Met Lys Ala Asn Glu Thr Lys Leu Glu Gly Asp Lys Arg Arg Leu
            660                 665                 670         
Lys Glu Val Leu Asp Ala Ser Glu Ser Arg Thr Val Lys Leu Glu Leu
        675                 680                 685             
Gln Arg Arg Ser Leu Glu Gly Glu Leu Gln Arg Ser Arg Leu Gly Leu
    690                 695                 700                 
Ser Asp Arg Glu Ala Gln Ala Gln Ala Leu Gln Asp Arg Val Asp Ser
705                 710                 715                 720 
Leu Gln Arg Gln Val Ala Asp Ser Glu Val Lys Ala Gly Thr Leu Gln
                725                 730                 735     
Leu Thr Val Glu Arg Leu Asn Gly Ala Leu Ala Lys Val Glu Glu Ser
            740                 745                 750         
Glu Gly Ala Leu Arg Asp Lys Val Arg Gly Leu Thr Glu Ala Leu Ala
        755                 760                 765             
Gln Ser Ser Ala Ser Leu Asn Ser Thr Arg Asp Lys Asn Leu His Leu
    770                 775                 780                 
Gln Lys Ala Leu Thr Ala Cys Glu His Asp Arg Gln Val Leu Gln Glu
785                 790                 795                 800 
Arg Leu Asp Ala Ala Arg Gln Ala Leu Ser Glu Ala Arg Lys Gln Ser
                805                 810                 815     
Ser Ser Leu Gly Glu Gln Val Gln Thr Leu Arg Gly Glu Val Ala Asp
            820                 825                 830         
Leu Glu Leu Gln Arg Val Glu Ala Glu Gly Gln Leu Gln Gln Leu Arg
        835                 840                 845             
Glu Val Leu Arg Gln Arg Gln Glu Gly Glu Ala Ala Ala Leu Asn Thr
    850                 855                 860                 
Val Gln Lys Leu Gln Asp Glu Arg Arg Leu Leu Gln Glu Arg Leu Gly
865                 870                 875                 880 
Ser Leu Gln Arg Ala Leu Ala Gln Leu Glu Ala Glu Lys Arg Glu Val
                885                 890                 895     
Glu Arg Ser Ala Leu Arg Leu Glu Lys Asp Arg Val Ala Leu Arg Arg
            900                 905                 910         
Thr Leu Asp Lys Val Glu Arg Glu Lys Leu Arg Ser His Glu Asp Thr
        915                 920                 925             
Val Arg Leu Ser Ala Glu Lys Gly Arg Leu Asp Arg Thr Leu Thr Gly
    930                 935                 940                 
Ala Glu Leu Glu Leu Ala Glu Ala Gln Arg Gln Ile Gln Gln Leu Glu
945                 950                 955                 960 
Ala Gln Val Val Val Leu Glu Gln Ser His Ser Pro Ala Gln Leu Glu
                965                 970                 975     
Val Asp Ala Gln Gln Gln Gln Leu Glu Leu Gln Gln Glu Val Glu Arg
            980                 985                 990         
Leu Arg Ser Ala Gln Ala Gln Thr Glu Arg Thr Leu Glu Ala Arg Glu
        995                 1000                1005            
Arg Ala His Arg Gln Arg Val Ser Thr Leu Lys Gly Gln Leu Gln Gln
    1010                1015                1020                
Glu Leu Arg Arg Ser Ser Ala Pro Phe Ser Pro Pro Ser Gly Pro Pro
1025                1030                1035                1040
Glu Lys
        


<210> 1656
<211> 280
<212> PRT
<213> Homo sapiens

<400> 1656
Met Ala Ala Val Val Ala Leu Ser Leu Arg Arg Arg Leu Pro Ala Thr
 1               5                  10                  15      
Thr Leu Gly Gly Ala Cys Leu Gln Ala Ser Arg Gly Ala Gln Thr Ala
            20                  25                  30          
Ala Ala Thr Ala Pro Arg Ile Lys Lys Phe Ala Ile Tyr Arg Trp Asp
        35                  40                  45              
Pro Asp Lys Ala Gly Asp Lys Pro His Met Gln Thr Tyr Glu Val Asp
    50                  55                  60                  
Leu Asn Lys Cys Gly Pro Met Val Leu Asp Ala Leu Ile Lys Ile Lys
65                  70                  75                  80  
Asn Glu Val Asp Ser Thr Leu Thr Phe Arg Arg Ser Cys Arg Glu Gly
                85                  90                  95      
Ile Cys Gly Ser Cys Ala Met Asn Ile Asn Gly Gly Asn Thr Leu Ala
            100                 105                 110         
Cys Thr Arg Arg Ile Asp Thr Asn Leu Asn Lys Val Ser Lys Ile Tyr
        115                 120                 125             
Pro Leu Pro His Met Tyr Val Ile Lys Asp Leu Val Pro Asp Leu Ser
    130                 135                 140                 
Asn Phe Tyr Ala Gln Tyr Lys Ser Ile Glu Pro Tyr Leu Lys Lys Lys
145                 150                 155                 160 
Asp Glu Ser Gln Glu Gly Lys Gln Gln Tyr Leu Gln Ser Ile Glu Glu
                165                 170                 175     
Arg Glu Lys Leu Asp Gly Leu Tyr Glu Cys Ile Leu Cys Ala Cys Cys
            180                 185                 190         
Ser Thr Ser Cys Pro Ser Tyr Trp Trp Asn Gly Asp Lys Tyr Leu Gly
        195                 200                 205             
Pro Ala Val Leu Met Gln Ala Tyr Arg Trp Met Ile Asp Ser Arg Asp
    210                 215                 220                 
Asp Phe Thr Glu Glu Arg Leu Ala Lys Leu Gln Asp Pro Phe Ser Leu
225                 230                 235                 240 
Tyr Arg Cys His Thr Ile Met Asn Cys Thr Arg Thr Cys Pro Lys Gly
                245                 250                 255     
Leu Asn Pro Gly Lys Ala Ile Ala Glu Ile Lys Lys Met Met Ala Thr
            260                 265                 270         
Tyr Lys Glu Lys Lys Ala Ser Val
        275                 280 


<210> 1657
<211> 220
<212> PRT
<213> Homo sapiens

<400> 1657
Met Ile Glu Ala Glu Ile Ser Phe Val Asp Ser Leu Gln Asp Leu Met
 1               5                  10                  15      
Gln Val Ile Glu Glu Leu Phe Lys Ala Thr Thr Met Met Val Leu Ser
            20                  25                  30          
Lys Cys Pro Glu Asp Val Glu Leu Cys His Lys Phe Ile Ala Pro Gly
        35                  40                  45              
Gln Lys Asp Arg Leu Glu His Met Leu Lys Asn Asn Phe Leu Ile Ile
    50                  55                  60                  
Ser Tyr Thr Glu Ala Val Glu Ile Leu Lys Gln Ala Ser Gln Asn Phe
65                  70                  75                  80  
Thr Phe Thr Pro Glu Trp Gly Ala Asp Leu Arg Thr Glu His Glu Lys
                85                  90                  95      
Tyr Leu Val Lys His Cys Gly Asn Ile Pro Val Phe Val Ile Asn Tyr
            100                 105                 110         
Pro Leu Thr Leu Lys Pro Phe Tyr Met Arg Asp Asn Glu Asp Gly Pro
        115                 120                 125             
Gln His Thr Val Ala Ala Val Asp Leu Leu Val Pro Gly Val Gly Glu
    130                 135                 140                 
Leu Phe Gly Gly Gly Leu Arg Glu Glu Arg Tyr His Phe Leu Glu Glu
145                 150                 155                 160 
Arg Leu Ala Arg Ser Gly Leu Thr Glu Val Tyr Gln Trp Tyr Leu Asp
                165                 170                 175     
Leu Arg Arg Phe Gly Ser Val Pro His Gly Gly Phe Gly Met Gly Phe
            180                 185                 190         
Glu Arg Tyr Leu Gln Cys Ile Leu Gly Val Asp Asn Ile Lys Asp Val
        195                 200                 205             
Ile Pro Phe Pro Arg Phe Pro His Ser Cys Leu Leu
    210                 215                 220 


<210> 1658
<211> 176
<212> PRT
<213> Homo sapiens

<400> 1658
Met Gln Lys Lys Ser Ser Ala Met Glu Gly Val Ser Thr Arg Arg Val
 1               5                  10                  15      
Ser Thr Ala Trp Pro Ala Gly Arg Leu Leu Thr Ala Arg Gln Ser Arg
            20                  25                  30          
Leu Met Ser Arg Arg Ser Thr Ala Arg Cys Ala Met Gly Ala Asp Met
        35                  40                  45              
Ala Pro Lys Gly Ser Gly Met Asp Lys Ala Leu Ala Val Ser Ala Gln
    50                  55                  60                  
Thr Arg Ala Ser Ile Ser Ala Cys Ser Ser Asn Arg Ser Pro Lys Pro
65                  70                  75                  80  
Ala Arg Ser Val Thr Thr Ser Asn Pro Ser Lys Phe Thr Ala Lys Phe
                85                  90                  95      
Gly Glu Ser Glu Lys Cys Pro Arg Cys Gly Lys Ser Val Tyr Ala Ala
            100                 105                 110         
Glu Lys Val Met Gly Gly Gly Lys Pro Trp His Lys Thr Cys Phe Arg
        115                 120                 125             
Cys Ala Ile Cys Gly Lys Ser Leu Glu Ser Thr Asn Val Thr Asp Lys
    130                 135                 140                 
Asp Gly Glu Leu Tyr Cys Lys Val Cys Tyr Ala Lys Asn Phe Gly Pro
145                 150                 155                 160 
Thr Gly Ile Gly Phe Gly Gly Leu Thr Gln Gln Val Glu Lys Lys Glu
                165                 170                 175     


<210> 1659
<211> 337
<212> PRT
<213> Homo sapiens

<400> 1659
Met Gly Asn Val Leu Gln Gly Gly Glu Gly Gln Ala Pro Thr Arg Gln
 1               5                  10                  15      
Ala Val Leu Gly Ala Gly Leu Pro Ile Ser Thr Pro Cys Thr Thr Ile
            20                  25                  30          
Asn Lys Val Cys Ala Ser Gly Met Lys Ala Ile Met Met Ala Ser Gln
        35                  40                  45              
Ser Leu Met Cys Gly His Gln Asp Val Met Val Ala Gly Gly Met Glu
    50                  55                  60                  
Ser Met Ser Asn Val Pro Tyr Val Met Asn Arg Gly Ser Thr Pro Tyr
65                  70                  75                  80  
Gly Gly Val Lys Leu Glu Asp Leu Ile Val Lys Asp Gly Leu Thr Asp
                85                  90                  95      
Val Tyr Asn Lys Ile His Met Gly Ser Cys Ala Glu Asn Thr Ala Lys
            100                 105                 110         
Lys Leu Asn Ile Ala Arg Asn Glu Gln Asp Ala Tyr Ala Ile Asn Ser
        115                 120                 125             
Tyr Thr Arg Ser Lys Ala Ala Trp Glu Ala Gly Lys Phe Gly Asn Glu
    130                 135                 140                 
Val Ile Pro Val Thr Val Thr Val Lys Gly Gln Pro Asp Val Val Val
145                 150                 155                 160 
Lys Glu Asp Glu Glu Tyr Lys Arg Val Asp Phe Ser Lys Val Pro Lys
                165                 170                 175     
Leu Lys Thr Val Phe Gln Lys Glu Asn Gly Thr Val Thr Ala Ala Asn
            180                 185                 190         
Ala Ser Thr Leu Asn Asp Gly Ala Ala Ala Leu Val Leu Met Thr Ala
        195                 200                 205             
Asp Ala Ala Lys Arg Leu Asn Val Thr Pro Leu Ala Arg Ile Val Ala
    210                 215                 220                 
Phe Ala Asp Ala Ala Val Glu Pro Ile Asp Phe Pro Ile Ala Pro Val
225                 230                 235                 240 
Tyr Ala Ala Ser Met Val Leu Lys Asp Val Gly Leu Lys Lys Glu Asp
                245                 250                 255     
Ile Ala Met Trp Glu Val Asn Glu Ala Phe Ser Leu Val Val Leu Ala
            260                 265                 270         
Asn Ile Lys Met Leu Glu Ile Asp Pro Gln Lys Val Asn Ile Asn Gly
        275                 280                 285             
Gly Ala Val Ser Leu Gly His Pro Ile Gly Met Ser Gly Ala Arg Ile
    290                 295                 300                 
Val Gly His Leu Thr His Ala Leu Lys Gln Gly Glu Tyr Gly Leu Ala
305                 310                 315                 320 
Ser Ile Cys Asn Gly Gly Gly Gly Ala Ser Ala Met Leu Ile Gln Lys
                325                 330                 335     
Leu
    


<210> 1660
<211> 494
<212> PRT
<213> Homo sapiens

<400> 1660
Met Thr Leu Gln Asp Arg Asn Glu Lys Leu Phe Tyr Arg Val Leu Thr
 1               5                  10                  15      
Ser Asp Val Glu Lys Phe Met Pro Ile Val Tyr Thr Pro Thr Val Gly
            20                  25                  30          
Leu Ala Cys Gln His Tyr Gly Leu Thr Phe Arg Arg Pro Arg Gly Leu
        35                  40                  45              
Phe Ile Thr Ile His Asp Lys Gly His Leu Ala Thr Met Leu Asn Ser
    50                  55                  60                  
Trp Pro Glu Asp Asn Ile Lys Ala Val Val Val Thr Asp Gly Glu Arg
65                  70                  75                  80  
Ile Leu Gly Leu Gly Asp Leu Gly Cys Tyr Gly Met Gly Ile Pro Val
                85                  90                  95      
Gly Lys Leu Ala Leu Tyr Thr Ala Cys Gly Gly Val Asn Pro Gln Gln
            100                 105                 110         
Cys Leu Pro Val Leu Leu Asp Val Gly Thr Asn Asn Glu Glu Leu Leu
        115                 120                 125             
Arg Asp Pro Leu Tyr Ile Gly Leu Lys His Gln Arg Val His Gly Lys
    130                 135                 140                 
Ala Tyr Asp Asp Leu Leu Asp Glu Phe Met Gln Ala Val Thr Asp Lys
145                 150                 155                 160 
Phe Gly Ile Asn Cys Leu Ile Gln Phe Glu Asp Phe Ala Asn Ala Asn
                165                 170                 175     
Ala Phe Arg Leu Leu Asn Lys Tyr Arg Asn Lys Tyr Cys Met Phe Asn
            180                 185                 190         
Asp Asp Ile Gln Gly Thr Ala Ser Val Ala Val Ala Gly Ile Leu Ala
        195                 200                 205             
Ala Leu Arg Ile Thr Lys Asn Lys Leu Ser Asn His Val Phe Val Phe
    210                 215                 220                 
Gln Gly Ala Gly Glu Ala Ala Met Gly Ile Ala His Leu Leu Val Met
225                 230                 235                 240 
Ala Leu Glu Lys Glu Gly Val Pro Lys Ala Glu Ala Thr Arg Lys Ile
                245                 250                 255     
Trp Met Val Asp Ser Lys Gly Leu Ile Val Lys Gly Arg Ser His Leu
            260                 265                 270         
Asn His Glu Lys Glu Met Phe Ala Gln Asp His Pro Glu Val Asn Ser
        275                 280                 285             
Leu Glu Glu Val Val Arg Leu Val Lys Pro Thr Ala Ile Ile Gly Val
    290                 295                 300                 
Ala Ala Ile Ala Gly Ala Phe Thr Glu Gln Ile Leu Arg Asp Met Ala
305                 310                 315                 320 
Ser Phe His Glu Arg Pro Ile Ile Phe Ala Leu Ser Asn Pro Thr Ser
                325                 330                 335     
Lys Ala Glu Cys Thr Ala Glu Lys Cys Tyr Arg Val Thr Glu Gly Arg
            340                 345                 350         
Gly Ile Phe Ala Ser Gly Ser Pro Phe Lys Ser Val Thr Leu Glu Asp
        355                 360                 365             
Gly Lys Thr Phe Ile Pro Gly Gln Gly Asn Asn Ala Tyr Val Phe Pro
    370                 375                 380                 
Gly Val Ala Leu Gly Val Ile Ala Gly Gly Ile Arg His Ile Pro Asp
385                 390                 395                 400 
Glu Ile Phe Leu Leu Thr Ala Glu Gln Ile Ala Gln Glu Val Ser Glu
                405                 410                 415     
Gln His Leu Ser Gln Gly Arg Leu Tyr Pro Pro Leu Ser Thr Ile Arg
            420                 425                 430         
Asp Val Ser Leu Arg Ile Ala Ile Lys Val Leu Asp Tyr Ala Tyr Lys
        435                 440                 445             
His Asn Leu Ala Ser Tyr Tyr Pro Glu Pro Lys Asp Lys Glu Ala Phe
    450                 455                 460                 
Val Arg Ser Leu Val Tyr Thr Pro Asp Tyr Asp Ser Phe Thr Leu Asp
465                 470                 475                 480 
Ser Tyr Thr Trp Pro Lys Glu Ala Met Asn Val Gln Thr Val
                485                 490                 


<210> 1661
<211> 1019
<212> PRT
<213> Homo sapiens

<400> 1661
Met Ala Gln Ile Ser Ser Asn Ser Gly Phe Lys Glu Cys Pro Ser Ser
 1               5                  10                  15      
His Pro Glu Pro Thr Arg Ala Lys Asp Val Asp Lys Glu Glu Ala Leu
            20                  25                  30          
Gln Met Glu Ala Glu Ala Leu Ala Lys Leu Gln Lys Asp Arg Gln Val
        35                  40                  45              
Thr Asp Asn Gln Arg Gly Phe Glu Leu Ser Ser Ser Thr Arg Lys Lys
    50                  55                  60                  
Ala Gln Val Tyr Asn Lys Gln Asp Tyr Asp Leu Met Val Phe Pro Glu
65                  70                  75                  80  
Ser Asp Ser Gln Lys Arg Ala Leu Asp Ile Asp Val Glu Lys Leu Thr
                85                  90                  95      
Gln Ala Glu Leu Glu Lys Leu Leu Leu Asp Asp Ser Phe Glu Thr Lys
            100                 105                 110         
Lys Thr Pro Val Leu Pro Val Thr Pro Ile Leu Ser Pro Ser Phe Ser
        115                 120                 125             
Ala Gln Leu Tyr Phe Arg Pro Thr Ile Gln Arg Gly Gln Trp Pro Pro
    130                 135                 140                 
Gly Leu Pro Gly Pro Ser Thr Tyr Ala Leu Pro Ser Ile Tyr Pro Ser
145                 150                 155                 160 
Thr Tyr Ser Lys Gln Ala Ala Phe Gln Asn Gly Phe Asn Pro Arg Met
                165                 170                 175     
Pro Thr Phe Pro Ser Thr Glu Pro Ile Tyr Leu Ser Leu Pro Gly Gln
            180                 185                 190         
Ser Pro Tyr Phe Ser Tyr Pro Leu Thr Pro Ala Thr Pro Phe His Pro
        195                 200                 205             
Gln Gly Ser Leu Pro Ile Tyr Arg Pro Val Val Ser Thr Asp Met Ala
    210                 215                 220                 
Lys Leu Phe Asp Lys Ile Ala Ser Thr Ser Glu Phe Leu Lys Asn Gly
225                 230                 235                 240 
Lys Ala Arg Thr Asp Leu Glu Ile Thr Asp Ser Lys Val Ser Asn Leu
                245                 250                 255     
Gln Val Ser Pro Lys Ser Glu Asp Ile Ser Lys Phe Asp Trp Leu Asp
            260                 265                 270         
Leu Asp Pro Leu Ser Lys Pro Lys Val Asp Asn Val Glu Val Leu Asp
        275                 280                 285             
His Glu Glu Glu Lys Asn Val Ser Ser Leu Leu Ala Lys Asp Pro Trp
    290                 295                 300                 
Asp Ala Val Leu Leu Glu Glu Arg Ser Thr Ala Asn Cys His Leu Glu
305                 310                 315                 320 
Arg Lys Val Asn Gly Lys Ser Leu Ser Val Ala Thr Val Thr Arg Ser
                325                 330                 335     
Gln Ser Leu Asn Ile Arg Thr Thr Gln Leu Ala Lys Ala Gln Gly His
            340                 345                 350         
Ile Ser Gln Lys Asp Pro Asn Gly Thr Ser Ser Leu Pro Thr Gly Ser
        355                 360                 365             
Ser Leu Leu Gln Glu Val Glu Val Gln Asn Glu Glu Met Ala Ala Phe
    370                 375                 380                 
Cys Arg Ser Ile Thr Lys Leu Lys Thr Lys Phe Pro Tyr Thr Asn His
385                 390                 395                 400 
Arg Thr Asn Pro Gly Tyr Leu Leu Ser Pro Val Thr Ala Gln Arg Asn
                405                 410                 415     
Ile Cys Gly Glu Asn Ala Ser Val Lys Val Ser Ile Asp Ile Glu Gly
            420                 425                 430         
Phe Gln Leu Pro Val Thr Phe Thr Cys Asp Val Ser Ser Thr Val Glu
        435                 440                 445             
Ile Ile Ile Met Gln Ala Leu Cys Trp Val His Asp Asp Leu Asn Gln
    450                 455                 460                 
Val Asp Val Gly Ser Tyr Val Leu Lys Val Cys Gly Gln Glu Glu Val
465                 470                 475                 480 
Leu Gln Asn Asn His Cys Leu Gly Ser His Glu His Ile Gln Asn Cys
                485                 490                 495     
Arg Lys Trp Asp Thr Glu Ile Arg Leu Gln Leu Leu Thr Phe Ser Ala
            500                 505                 510         
Met Cys Gln Asn Leu Ala Arg Thr Ala Glu Asp Asp Glu Thr Pro Val
        515                 520                 525             
Asp Leu Asn Lys His Leu Tyr Gln Ile Glu Lys Pro Cys Lys Glu Ala
    530                 535                 540                 
Met Thr Arg His Pro Val Glu Glu Leu Leu Asp Ser Tyr His Asn Gln
545                 550                 555                 560 
Val Glu Leu Ala Leu Gln Ile Glu Asn Gln His Arg Ala Val Asp Gln
                565                 570                 575     
Val Ile Lys Ala Val Arg Lys Ile Cys Ser Ala Leu Asp Gly Val Glu
            580                 585                 590         
Thr Leu Ala Ile Thr Glu Ser Val Lys Lys Leu Lys Arg Ala Val Asn
        595                 600                 605             
Leu Pro Arg Ser Lys Thr Ala Asp Val Thr Ser Leu Phe Gly Gly Glu
    610                 615                 620                 
Asp Thr Ser Arg Ser Ser Thr Arg Gly Ser Leu Asn Pro Glu Asn Pro
625                 630                 635                 640 
Val Gln Val Ser Ile Asn Gln Leu Thr Ala Ala Ile Tyr Asp Leu Leu
                645                 650                 655     
Arg Leu His Ala Asn Ser Gly Arg Ser Pro Thr Asp Cys Ala Gln Ser
            660                 665                 670         
Ser Lys Ser Val Lys Glu Ala Trp Thr Thr Thr Glu Gln Leu Gln Phe
        675                 680                 685             
Thr Ile Phe Ala Ala His Gly Ile Ser Ser Asn Trp Val Ser Asn Tyr
    690                 695                 700                 
Glu Lys Tyr Tyr Leu Ile Cys Ser Leu Ser His Asn Gly Lys Asp Leu
705                 710                 715                 720 
Phe Lys Pro Ile Gln Ser Lys Lys Val Gly Thr Tyr Lys Asn Phe Phe
                725                 730                 735     
Tyr Leu Ile Lys Trp Asp Glu Leu Ile Ile Phe Pro Ile Gln Ile Ser
            740                 745                 750         
Gln Leu Pro Leu Glu Ser Val Leu His Leu Thr Leu Phe Gly Ile Leu
        755                 760                 765             
Asn Gln Ser Ser Gly Ser Ser Pro Asp Ser Asn Lys Gln Arg Lys Gly
    770                 775                 780                 
Pro Glu Ala Leu Gly Lys Val Ser Leu Pro Leu Phe Asp Phe Lys Arg
785                 790                 795                 800 
Phe Leu Thr Cys Gly Thr Lys Leu Leu Tyr Leu Trp Thr Ser Ser His
                805                 810                 815     
Thr Asn Ser Val Pro Gly Thr Val Thr Lys Lys Gly Tyr Val Met Glu
            820                 825                 830         
Arg Ile Val Leu Gln Val Asp Phe Pro Ser Pro Ala Phe Asp Ile Ile
        835                 840                 845             
Tyr Thr Thr Pro Gln Val Asp Arg Ser Ile Ile Gln Gln His Asn Leu
    850                 855                 860                 
Glu Thr Leu Glu Asn Asp Ile Lys Gly Lys Leu Leu Asp Ile Leu His
865                 870                 875                 880 
Lys Asp Ser Ser Leu Gly Leu Ser Lys Glu Asp Lys Ala Phe Leu Trp
                885                 890                 895     
Glu Lys Arg Tyr Tyr Cys Phe Lys His Pro Asn Cys Leu Pro Lys Ile
            900                 905                 910         
Leu Ala Ser Ala Pro Asn Trp Lys Trp Val Asn Leu Ala Lys Thr Tyr
        915                 920                 925             
Ser Leu Leu His Gln Trp Pro Ala Leu Tyr Pro Leu Ile Ala Leu Glu
    930                 935                 940                 
Leu Leu Asp Ser Lys Phe Ala Asp Gln Glu Val Arg Ser Leu Ala Val
945                 950                 955                 960 
Thr Trp Ile Glu Ala Ile Ser Asp Asp Glu Leu Thr Asp Leu Leu Pro
                965                 970                 975     
Gln Phe Val Gln Ala Leu Lys Tyr Glu Ile Tyr Leu Asn Ser Ser Leu
            980                 985                 990         
Val Gln Phe Leu Leu Ser Arg Ala Leu Gly Asn Ile Gln Ile Ala His
        995                 1000                1005            
Asn Leu Tyr Trp Ala Ser Gln Arg Cys Pro Ala
    1010                1015                


<210> 1662
<211> 185
<212> PRT
<213> Homo sapiens

<400> 1662
Met Ser Ser Ser Cys Ser Gly Leu Ser Arg Val Leu Val Ala Val Ala
 1               5                  10                  15      
Thr Ala Leu Val Ser Ala Ser Ser Pro Cys Pro Gln Ala Trp Gly Pro
            20                  25                  30          
Pro Gly Val Gln Tyr Gly Gln Pro Gly Arg Ser Val Lys Leu Cys Cys
        35                  40                  45              
Pro Gly Val Thr Ala Gly Asp Pro Val Ser Trp Phe Arg Asp Gly Glu
    50                  55                  60                  
Pro Lys Leu Leu Gln Gly Pro Asp Ser Gly Leu Gly His Glu Leu Val
65                  70                  75                  80  
Leu Ala Gln Ala Asp Ser Thr Asp Glu Gly Thr Tyr Ile Cys Gln Thr
                85                  90                  95      
Leu Asp Gly Ala Leu Gly Gly Thr Val Thr Leu Gln Leu Gly Tyr Pro
            100                 105                 110         
Pro Ala Arg Pro Val Val Ser Cys Gln Ala Ala Asp Tyr Glu Asn Phe
        115                 120                 125             
Ser Cys Thr Trp Ser Pro Ser Gln Ile Ser Gly Leu Pro Thr Arg Tyr
    130                 135                 140                 
Leu Thr Ser Tyr Arg Lys Lys Thr Val Leu Gly Ala Asp Ser Gln Arg
145                 150                 155                 160 
Glu Glu Ser Ile His Arg Ala Leu Ala Met Pro Thr Gly Ser Pro Arg
                165                 170                 175     
Gly Cys Pro Leu Cys Cys Pro Arg Gly
            180                 185 


<210> 1663
<211> 346
<212> PRT
<213> Homo sapiens

<400> 1663
Met Gly Pro Ala Val Ser Pro Trp Thr Arg Arg Ala Pro Cys Arg Gly
 1               5                  10                  15      
Leu Pro Asp Pro Arg Cys Pro Gly His Ser Gly Gly Ser Arg Gly Gln
            20                  25                  30          
Gln Leu Pro Val Ser Ser Phe Arg Gly Ile Lys Gly Gly Arg Arg Ser
        35                  40                  45              
Ile Ser Phe Ser Val Gly Ala Ser Ser Val Val Gly Ser Gly Gly Ser
    50                  55                  60                  
Ser Asp Lys Gly Lys Leu Ser Leu Gln Asp Val Ala Glu Leu Ile Arg
65                  70                  75                  80  
Ala Arg Ala Cys Gln Arg Val Val Val Met Val Gly Ala Gly Ile Ser
                85                  90                  95      
Thr Pro Ser Gly Ile Pro Asp Phe Arg Ser Pro Gly Ser Gly Leu Tyr
            100                 105                 110         
Ser Asn Leu Gln Gln Tyr Asp Leu Pro Tyr Pro Glu Ala Ile Phe Glu
        115                 120                 125             
Leu Pro Phe Phe Phe His Asn Pro Lys Pro Phe Phe Thr Leu Ala Lys
    130                 135                 140                 
Glu Leu Tyr Pro Gly Asn Tyr Lys Pro Asn Val Thr His Tyr Phe Leu
145                 150                 155                 160 
Arg Leu Leu His Asp Lys Gly Leu Leu Leu Arg Leu Tyr Thr Gln Asn
                165                 170                 175     
Ile Asp Gly Leu Glu Arg Val Ser Gly Ile Pro Ala Ser Lys Leu Val
            180                 185                 190         
Glu Ala His Gly Thr Phe Ala Ser Ala Thr Cys Thr Val Cys Gln Arg
        195                 200                 205             
Pro Phe Pro Gly Glu Asp Ile Arg Ala Asp Val Met Ala Asp Arg Val
    210                 215                 220                 
Pro Arg Cys Pro Val Cys Thr Gly Val Val Lys Pro Asp Ile Val Phe
225                 230                 235                 240 
Phe Gly Glu Pro Leu Pro Gln Arg Phe Leu Leu His Val Val Asp Phe
                245                 250                 255     
Pro Met Ala Asp Leu Leu Leu Ile Leu Gly Asn Ser Leu Glu Val Glu
            260                 265                 270         
Pro Phe Ala Ser Leu Thr Glu Ala Val Arg Ser Ser Val Pro Arg Leu
        275                 280                 285             
Leu Ile Asn Arg Asp Leu Val Gly Pro Leu Ala Trp His Pro Arg Ser
    290                 295                 300                 
Arg Asp Val Ala Gln Leu Gly Asp Val Val His Gly Val Glu Ser Leu
305                 310                 315                 320 
Val Glu Leu Leu Gly Trp Thr Glu Glu Met Arg Asp Leu Val Gln Arg
                325                 330                 335     
Glu Thr Gly Lys Leu Asp Gly Pro Asp Lys
            340                 345     


<210> 1664
<211> 672
<212> PRT
<213> Homo sapiens

<400> 1664
Met Cys Tyr Lys Gln Ala Val Ser Val Asp Glu Met Arg Gly Thr Ile
 1               5                  10                  15      
Thr Val His Lys Thr Asp Ser Ser Asn Glu Pro Pro Lys Thr Phe Thr
            20                  25                  30          
Phe Asp Thr Val Phe Gly Pro Glu Ser Lys Gln Leu Asp Val Tyr Asn
        35                  40                  45              
Leu Thr Ala Arg Pro Ile Ile Asp Ser Val Leu Glu Gly Tyr Asn Gly
    50                  55                  60                  
Thr Ile Phe Ala Tyr Gly Gln Thr Gly Thr Gly Lys Thr Phe Thr Met
65                  70                  75                  80  
Glu Gly Val Arg Ala Ile Pro Glu Leu Arg Gly Ile Ile Pro Asn Ser
                85                  90                  95      
Phe Ala His Ile Phe Gly His Ile Ala Lys Ala Glu Gly Asp Thr Arg
            100                 105                 110         
Phe Leu Val Arg Val Ser Tyr Leu Glu Ile Tyr Asn Glu Glu Val Arg
        115                 120                 125             
Asp Leu Leu Gly Lys Asp Gln Thr Gln Arg Leu Glu Val Lys Glu Arg
    130                 135                 140                 
Pro Asp Val Gly Val Tyr Ile Lys Asp Leu Ser Ala Tyr Val Val Asn
145                 150                 155                 160 
Asn Ala Asp Asp Met Asp Arg Ile Met Thr Leu Gly His Lys Asn Arg
                165                 170                 175     
Ser Val Gly Ala Thr Asn Met Asn Glu His Ser Ser Arg Ser His Ala
            180                 185                 190         
Ile Phe Thr Ile Thr Ile Glu Cys Ser Glu Lys Gly Ile Asp Gly Asn
        195                 200                 205             
Met His Val Arg Met Gly Lys Leu His Leu Val Asp Leu Ala Gly Ser
    210                 215                 220                 
Glu Arg Gln Ala Lys Thr Gly Ala Thr Gly Gln Arg Leu Lys Glu Ala
225                 230                 235                 240 
Thr Lys Ile Asn Leu Ser Leu Ser Thr Leu Gly Asn Val Ile Ser Ala
                245                 250                 255     
Leu Val Asp Gly Lys Ser Thr His Val Pro Tyr Arg Asn Ser Lys Leu
            260                 265                 270         
Thr Arg Leu Leu Gln Asp Ser Leu Gly Gly Asn Ser Lys Thr Met Met
        275                 280                 285             
Cys Ala Asn Ile Gly Pro Ala Asp Tyr Asn Tyr Asp Glu Thr Ile Ser
    290                 295                 300                 
Thr Leu Arg Tyr Ala Asn Arg Ala Lys Asn Ile Lys Asn Lys Ala Arg
305                 310                 315                 320 
Ile Asn Glu Asp Pro Lys Asp Ala Leu Leu Arg Gln Phe Gln Lys Glu
                325                 330                 335     
Ile Glu Glu Leu Lys Lys Lys Leu Glu Glu Gly Glu Glu Ile Ser Gly
            340                 345                 350         
Ser Asp Ile Ser Gly Ser Glu Glu Asp Asp Asp Glu Glu Gly Glu Val
        355                 360                 365             
Gly Glu Asp Gly Glu Lys Arg Lys Lys Arg Arg Ile Gln Ile Gly Lys
    370                 375                 380                 
Lys Lys Val Ser Pro Asp Lys Met Ile Glu Met Gln Ala Lys Ile Asp
385                 390                 395                 400 
Glu Glu Arg Lys Ala Leu Glu Thr Lys Leu Asp Met Glu Glu Glu Glu
                405                 410                 415     
Arg Asn Lys Ala Arg Ala Glu Leu Glu Lys Arg Glu Lys Asp Leu Leu
            420                 425                 430         
Lys Ala Gln Gln Glu His Gln Ser Leu Leu Glu Lys Leu Ser Ala Leu
        435                 440                 445             
Glu Lys Lys Val Ile Val Gly Gly Val Asp Leu Leu Ala Lys Ala Glu
    450                 455                 460                 
Glu Gln Glu Lys Leu Leu Glu Glu Ser Asn Met Glu Leu Glu Glu Arg
465                 470                 475                 480 
Arg Lys Arg Ala Glu Gln Leu Arg Arg Glu Leu Glu Glu Lys Glu Gln
                485                 490                 495     
Glu Arg Leu Asp Ile Glu Glu Lys Tyr Thr Ser Leu Gln Glu Glu Ala
            500                 505                 510         
Gln Gly Lys Thr Lys Lys Leu Lys Lys Val Trp Thr Met Leu Met Ala
        515                 520                 525             
Ala Lys Ser Glu Met Ala Asp Leu Gln Gln Glu His Gln Arg Glu Ile
    530                 535                 540                 
Glu Gly Leu Leu Glu Asn Ile Arg Gln Leu Ser Arg Glu Leu Arg Leu
545                 550                 555                 560 
Gln Met Leu Ile Ile Asp Asn Phe Ile Pro Arg Asp Tyr Gln Glu Met
                565                 570                 575     
Ile Glu Asn Tyr Val His Trp Asn Glu Asp Ile Gly Glu Trp Gln Leu
            580                 585                 590         
Lys Cys Val Ala Tyr Thr Gly Asn Asn Met Arg Lys Gln Thr Pro Val
        595                 600                 605             
Pro Asp Lys Lys Glu Lys Asp Pro Phe Glu Val Asp Leu Ser His Val
    610                 615                 620                 
Tyr Leu Ala Tyr Thr Glu Glu Ser Leu Arg Gln Ser Leu Met Lys Leu
625                 630                 635                 640 
Glu Arg Pro Arg Thr Ser Lys Gly Lys Ala Arg Pro Lys Thr Gly Arg
                645                 650                 655     
Arg Lys Arg Ser Ala Lys Pro Glu Thr Val Ile Asp Ser Leu Leu Gln
            660                 665                 670         


<210> 1665
<211> 81
<212> PRT
<213> Homo sapiens

<400> 1665
Met Pro Asn Thr Gly Tyr Gly Ser Asn Lys Lys Thr Lys His Met Leu
 1               5                  10                  15      
Pro Ser Gly Phe Arg Lys Phe Leu Val His Asn Val Lys Glu Leu Glu
            20                  25                  30          
Val Leu Leu Met Cys Asn Asn Arg Thr Cys Ala Glu Ile Ala His Asn
        35                  40                  45              
Val Ser Ser Lys Asn Arg Lys Ala Ile Val Glu Arg Ala Ala Gln Leu
    50                  55                  60                  
Ala Ile Thr Val Thr Asn Pro Ser Ala Arg Leu Cys Ser Glu Glu Asn
65                  70                  75                  80  
Glu
    


<210> 1666
<211> 250
<212> PRT
<213> Homo sapiens

<400> 1666
Met Asn Asp Leu Arg Val Pro Phe Ile Arg Asp Asn Leu Leu Lys Thr
 1               5                  10                  15      
Ile Pro Asn His Gln Pro Gly Lys Pro Leu Leu Gly Met Lys Ile Leu
            20                  25                  30          
Asp Val Gly Cys Gly Gly Gly Leu Leu Thr Glu Pro Leu Gly Arg Leu
        35                  40                  45              
Gly Ala Ser Val Ile Gly Ile Asp Pro Val Asp Glu Asn Ile Lys Thr
    50                  55                  60                  
Ala Gln Cys His Lys Ser Phe Asp Pro Val Leu Asp Lys Arg Ile Glu
65                  70                  75                  80  
Tyr Arg Val Cys Ser Leu Glu Glu Ile Val Glu Glu Thr Ala Glu Thr
                85                  90                  95      
Phe Asp Ala Val Val Ala Ser Glu Val Val Glu His Val Ile Asp Leu
            100                 105                 110         
Glu Thr Phe Leu Gln Cys Cys Cys Gln Val Leu Lys Pro Gly Gly Ser
        115                 120                 125             
Leu Phe Ile Thr Thr Ile Asn Lys Thr Gln Leu Ser Tyr Ala Leu Gly
    130                 135                 140                 
Ile Val Phe Ser Glu Gln Ile Ala Ser Ile Val Pro Lys Gly Thr His
145                 150                 155                 160 
Thr Trp Glu Lys Phe Val Ser Pro Glu Thr Leu Glu Ser Ile Leu Glu
                165                 170                 175     
Ser Asn Gly Leu Ser Val Gln Thr Val Val Gly Met Leu Tyr Asn Pro
            180                 185                 190         
Phe Ser Gly Tyr Trp His Trp Ser Glu Asn Thr Ser Leu Asn Tyr Ala
        195                 200                 205             
Ala Tyr Ala Val Lys Ser Arg Val Gln Glu His Pro Ala Ser Ala Glu
    210                 215                 220                 
Phe Val Leu Lys Gly Glu Thr Glu Glu Leu Gln Ala Asn Ala Cys Thr
225                 230                 235                 240 
Asn Pro Ala Val His Glu Lys Leu Lys Lys
                245                 250 


<210> 1667
<211> 165
<212> PRT
<213> Homo sapiens

<400> 1667
Met Pro Pro Lys Phe Asp Pro Asn Glu Ile Lys Val Val Tyr Leu Arg
 1               5                  10                  15      
Cys Thr Gly Gly Glu Val Gly Ala Thr Ser Ala Leu Ala Pro Lys Ile
            20                  25                  30          
Gly Pro Leu Gly Leu Ser Pro Lys Lys Val Gly Asp Asp Ile Ala Lys
        35                  40                  45              
Ala Thr Gly Asp Trp Lys Gly Leu Arg Ile Thr Val Lys Leu Thr Ile
    50                  55                  60                  
Gln Asn Arg Gln Ala Gln Ile Glu Val Val Pro Ser Ala Ser Ala Leu
65                  70                  75                  80  
Ile Ile Lys Ala Leu Lys Glu Pro Pro Arg Asp Arg Lys Lys Gln Lys
                85                  90                  95      
Asn Ile Lys His Ser Gly Asn Ile Thr Phe Asp Glu Ile Val Asn Ile
            100                 105                 110         
Val Arg Gln Met Arg His Arg Ser Leu Ala Arg Glu Leu Ser Gly Thr
        115                 120                 125             
Ile Lys Glu Ile Leu Gly Thr Ala Gln Ser Val Gly Cys Asn Val Asp
    130                 135                 140                 
Gly Arg His Pro His Asp Ile Ile Asp Asp Ile Asn Ser Gly Ala Val
145                 150                 155                 160 
Glu Cys Pro Ala Ser
                165 


<210> 1668
<211> 91
<212> PRT
<213> Homo sapiens

<400> 1668
Met Ala Cys Thr Thr Pro Val Arg Ile Ile Ser Gly Pro Ala Ser Arg
 1               5                  10                  15      
Thr Leu Cys Ala Pro Ser Phe Leu Gly Ile Asn Trp Lys Thr Arg Ile
            20                  25                  30          
Pro Ala Cys Thr Phe Pro Pro Gly Arg Ser Glu Met Pro Thr Pro Ala
        35                  40                  45              
Ser Thr Lys Ala Arg Ser Ala Ala Trp Ser Pro Ala Ser Ile Ser Pro
    50                  55                  60                  
Phe Ala Arg Lys Thr Ala Ser Lys Ser Thr Tyr Thr His Ser Lys Lys
65                  70                  75                  80  
Gly Arg Lys Ser Pro Lys Val Thr Lys Thr Phe
                85                  90      


<210> 1669
<211> 372
<212> PRT
<213> Homo sapiens

<400> 1669
Met Leu Pro Lys Ser Gln Val Thr Asp Thr Leu Ala Lys Glu Gly Pro
 1               5                  10                  15      
Ser Tyr Pro Ser Tyr Asp Trp Phe Gln Thr Asp Ser Leu Val Thr Ile
            20                  25                  30          
Ala Ile Tyr Thr Lys Gln Lys Asp Ile Asn Leu Asp Ser Ile Ile Val
        35                  40                  45              
Asp His Gln Asn Asp Ser Phe Arg Ala Glu Thr Ile Ile Lys Asp Cys
    50                  55                  60                  
Leu Tyr Leu Ile His Ile Gly Leu Ser His Glu Val Gln Glu Asp Phe
65                  70                  75                  80  
Ser Val Arg Val Val Glu Ser Val Gly Lys Ile Glu Ile Val Leu Gln
                85                  90                  95      
Lys Lys Glu Asn Thr Ser Trp Asp Phe Leu Gly His Pro Leu Lys Asn
            100                 105                 110         
His Asn Ser Leu Ile Pro Arg Lys Asp Thr Gly Leu Tyr Tyr Arg Lys
        115                 120                 125             
Cys Gln Leu Ile Ser Lys Glu Asp Val Thr His Asp Thr Arg Leu Phe
    130                 135                 140                 
Cys Leu Met Leu Pro Pro Ser Thr His Leu Gln Val Pro Ile Gly Gln
145                 150                 155                 160 
His Val Tyr Leu Lys Leu Pro Ile Thr Gly Thr Glu Ile Val Lys Pro
                165                 170                 175     
Tyr Thr Pro Val Ser Gly Ser Leu Leu Ser Glu Phe Lys Glu Pro Val
            180                 185                 190         
Leu Pro Asn Asn Lys Tyr Ile Tyr Phe Leu Ile Lys Ile Tyr Pro Thr
        195                 200                 205             
Gly Leu Phe Thr Pro Glu Leu Asp Arg Leu Gln Ile Gly Asp Phe Val
    210                 215                 220                 
Ser Val Ser Ser Pro Glu Gly Asn Phe Lys Ile Ser Lys Phe Gln Glu
225                 230                 235                 240 
Leu Glu Asp Leu Phe Leu Leu Ala Ala Gly Thr Gly Phe Thr Pro Met
                245                 250                 255     
Val Lys Ile Leu Asn Tyr Ala Leu Thr Asp Ile Pro Ser Leu Arg Lys
            260                 265                 270         
Val Lys Leu Met Phe Phe Asn Lys Thr Glu Asp Asp Ile Ile Trp Arg
        275                 280                 285             
Ser Gln Leu Glu Lys Leu Ala Phe Lys Asp Lys Arg Leu Asp Val Glu
    290                 295                 300                 
Phe Val Leu Ser Ala Pro Ile Ser Glu Trp Asn Gly Lys Gln Gly His
305                 310                 315                 320 
Ile Ser Pro Ala Leu Leu Ser Glu Phe Leu Lys Arg Asn Leu Asp Lys
                325                 330                 335     
Ser Lys Val Leu Val Cys Ile Cys Gly Pro Val Pro Phe Thr Glu Gln
            340                 345                 350         
Gly Val Arg Leu Leu His Asp Leu Asn Phe Ser Lys Asn Glu Ile His
        355                 360                 365             
Ser Phe Thr Ala
    370         


<210> 1670
<211> 344
<212> PRT
<213> Homo sapiens

<400> 1670
Met Leu Glu Arg Ile Lys His Glu Lys Thr Val Asp Ile Tyr Gly His
 1               5                  10                  15      
Val Thr Leu Met Arg Ala Gln Arg Asn Tyr Met Val Gln Thr Glu Asp
            20                  25                  30          
Gln Tyr Ile Phe Ile His Asp Ala Leu Leu Glu Ala Val Thr Cys Gly
        35                  40                  45              
Asn Thr Glu Val Pro Ala Arg Asn Leu Tyr Ala Tyr Ile Gln Lys Leu
    50                  55                  60                  
Thr Gln Ile Glu Thr Gly Glu Asn Val Thr Gly Met Glu Leu Glu Phe
65                  70                  75                  80  
Lys Arg Leu Ala Ser Ser Lys Ala His Thr Ser Arg Phe Ile Ser Ala
                85                  90                  95      
Asn Leu Pro Cys Asn Lys Phe Lys Asn Arg Leu Val Asn Ile Met Pro
            100                 105                 110         
Tyr Glu Ser Thr Arg Val Cys Leu Gln Pro Ile Arg Gly Val Glu Gly
        115                 120                 125             
Ser Asp Tyr Ile Asn Ala Ser Phe Ile Asp Gly Tyr Arg Gln Gln Lys
    130                 135                 140                 
Ala Tyr Ile Ala Thr Gln Gly Pro Leu Ala Glu Thr Thr Glu Asp Phe
145                 150                 155                 160 
Trp Arg Met Leu Trp Glu His Asn Ser Thr Ile Val Val Met Leu Thr
                165                 170                 175     
Lys Leu Arg Glu Met Gly Arg Glu Lys Cys His Gln Tyr Trp Pro Ala
            180                 185                 190         
Glu Arg Ser Ala Arg Tyr Gln Tyr Phe Val Val Asp Pro Met Ala Glu
        195                 200                 205             
Tyr Asn Met Pro Gln Tyr Ile Leu Arg Glu Phe Lys Val Thr Asp Ala
    210                 215                 220                 
Arg Asp Gly Gln Ser Arg Thr Val Arg Gln Phe Gln Phe Thr Asp Trp
225                 230                 235                 240 
Pro Glu Gln Gly Val Pro Lys Ser Gly Glu Gly Phe Ile Asp Phe Ile
                245                 250                 255     
Gly Gln Val His Lys Thr Lys Glu Gln Phe Gly Gln Asp Gly Pro Ile
            260                 265                 270         
Ser Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Val Phe Ile Thr
        275                 280                 285             
Leu Ser Ile Val Leu Glu Arg Met Arg Tyr Glu Gly Val Val Asp Ile
    290                 295                 300                 
Phe Gln Thr Val Lys Met Leu Arg Thr Gln Arg Pro Ala Met Val Gln
305                 310                 315                 320 
Thr Glu Asp Gln Tyr Gln Phe Ser Tyr Arg Ala Ala Leu Glu Tyr Leu
                325                 330                 335     
Gly Ser Phe Asp His Tyr Ala Thr
            340                 


<210> 1671
<211> 953
<212> PRT
<213> Homo sapiens

<400> 1671
Met Ile Thr Ser Ala Ala Gly Ile Ile Ser Leu Leu Asp Glu Asp Glu
 1               5                  10                  15      
Pro Gln Leu Lys Glu Phe Ala Leu His Lys Leu Asn Ala Val Val Asn
            20                  25                  30          
Asp Phe Trp Ala Glu Ile Ser Glu Ser Val Asp Lys Ile Glu Val Leu
        35                  40                  45              
Tyr Glu Asp Glu Gly Phe Arg Ser Arg Gln Phe Ala Ala Leu Val Ala
    50                  55                  60                  
Ser Lys Val Phe Tyr His Leu Gly Ala Phe Glu Glu Ser Leu Asn Tyr
65                  70                  75                  80  
Ala Leu Gly Ala Gly Asp Leu Phe Asn Val Asn Asp Asn Ser Glu Tyr
                85                  90                  95      
Val Glu Thr Ile Ile Ala Lys Cys Ile Asp His Tyr Thr Lys Gln Cys
            100                 105                 110         
Val Glu Asn Ala Asp Leu Pro Glu Gly Glu Lys Lys Pro Ile Asp Gln
        115                 120                 125             
Arg Leu Glu Gly Ile Val Asn Lys Met Phe Gln Arg Cys Leu Asp Asp
    130                 135                 140                 
His Lys Tyr Lys Gln Ala Ile Gly Ile Ala Leu Glu Thr Arg Arg Leu
145                 150                 155                 160 
Asp Val Phe Glu Lys Thr Ile Leu Glu Ser Asn Asp Val Pro Gly Met
                165                 170                 175     
Leu Ala Tyr Ser Leu Lys Leu Cys Met Ser Leu Met Gln Asn Lys Gln
            180                 185                 190         
Phe Arg Asn Lys Val Leu Arg Val Leu Val Lys Ile Tyr Met Asn Leu
        195                 200                 205             
Glu Lys Pro Asp Phe Ile Asn Val Cys Gln Cys Leu Ile Phe Leu Asp
    210                 215                 220                 
Asp Pro Gln Ala Val Ser Asp Ile Leu Glu Lys Leu Val Lys Glu Asp
225                 230                 235                 240 
Asn Leu Leu Met Ala Tyr Gln Ile Cys Phe Asp Leu Tyr Glu Ser Ala
                245                 250                 255     
Ser Gln Gln Phe Leu Ser Ser Val Ile Gln Asn Leu Arg Thr Val Gly
            260                 265                 270         
Thr Pro Ile Ala Ser Val Pro Gly Ser Thr Asn Thr Gly Thr Val Pro
        275                 280                 285             
Gly Ser Glu Lys Asp Ser Asp Ser Met Glu Thr Glu Glu Lys Thr Ser
    290                 295                 300                 
Ser Ala Phe Val Gly Lys Thr Pro Glu Ala Ser Pro Glu Pro Lys Asp
305                 310                 315                 320 
Gln Thr Leu Lys Met Ile Lys Ile Leu Ser Gly Glu Met Ala Ile Glu
                325                 330                 335     
Leu His Leu Gln Phe Leu Ile Arg Asn Asn Asn Thr Asp Leu Met Ile
            340                 345                 350         
Leu Lys Asn Thr Lys Asp Ala Val Arg Asn Ser Val Cys His Thr Ala
        355                 360                 365             
Thr Val Ile Ala Asn Ser Phe Met His Cys Gly Thr Thr Ser Asp Gln
    370                 375                 380                 
Phe Leu Arg Asp Asn Leu Glu Trp Leu Ala Arg Ala Thr Asn Trp Ala
385                 390                 395                 400 
Lys Phe Thr Ala Thr Ala Ser Leu Gly Val Ile His Lys Gly His Glu
                405                 410                 415     
Lys Glu Ala Leu Gln Leu Met Ala Thr Tyr Leu Pro Lys Asp Thr Ser
            420                 425                 430         
Pro Gly Ser Ala Tyr Gln Glu Gly Gly Gly Leu Tyr Ala Leu Gly Leu
        435                 440                 445             
Ile His Ala Asn His Gly Gly Asp Ile Ile Asp Tyr Leu Leu Asn Gln
    450                 455                 460                 
Leu Lys Asn Ala Ser Asn Asp Ile Val Arg His Gly Gly Ser Leu Gly
465                 470                 475                 480 
Leu Gly Leu Ala Ala Met Gly Thr Ala Arg Gln Asp Val Tyr Asp Leu
                485                 490                 495     
Leu Lys Thr Asn Leu Tyr Gln Asp Asp Ala Val Thr Gly Glu Ala Ala
            500                 505                 510         
Gly Leu Ala Leu Gly Leu Val Met Leu Gly Ser Lys Asn Ala Gln Ala
        515                 520                 525             
Ile Glu Asp Met Val Gly Tyr Ala Gln Glu Thr Gln His Glu Lys Ile
    530                 535                 540                 
Leu Arg Gly Leu Ala Val Gly Ile Ala Leu Val Met Tyr Gly Arg Met
545                 550                 555                 560 
Glu Glu Ala Asp Ala Leu Ile Glu Ser Leu Cys Arg Asp Lys Asp Pro
                565                 570                 575     
Ile Leu Arg Arg Ser Gly Met Tyr Thr Val Ala Met Ala Tyr Cys Gly
            580                 585                 590         
Ser Gly Asn Asn Lys Ala Ile Arg Arg Leu Leu His Val Ala Val Ser
        595                 600                 605             
Asp Val Asn Asp Asp Val Arg Arg Ala Ala Val Glu Ser Leu Gly Phe
    610                 615                 620                 
Ile Leu Phe Arg Thr Pro Glu Gln Cys Pro Ser Val Val Ser Leu Leu
625                 630                 635                 640 
Ser Glu Ser Tyr Asn Pro His Val Arg Tyr Gly Ala Ala Met Ala Leu
                645                 650                 655     
Gly Ile Cys Cys Ala Gly Thr Gly Asn Lys Glu Ala Ile Asn Leu Leu
            660                 665                 670         
Glu Pro Met Thr Asn Asp Pro Val Asn Tyr Val Arg Gln Gly Ala Leu
        675                 680                 685             
Ile Ala Ser Ala Leu Ile Met Ile Gln Gln Thr Glu Ile Thr Cys Pro
    690                 695                 700                 
Lys Val Asn Gln Phe Arg Gln Leu Tyr Ser Lys Val Ile Asn Asp Lys
705                 710                 715                 720 
His Asp Asp Val Met Ala Lys Phe Gly Ala Ile Leu Ala Gln Gly Ile
                725                 730                 735     
Leu Asp Ala Gly Gly His Asn Val Thr Ile Ser Leu Gln Ser Arg Thr
            740                 745                 750         
Gly His Thr His Met Pro Ser Val Val Gly Val Leu Val Phe Thr Gln
        755                 760                 765             
Phe Trp Phe Trp Phe Pro Leu Ser His Phe Leu Ser Leu Ala Tyr Thr
    770                 775                 780                 
Pro Thr Cys Val Ile Gly Leu Asn Lys Asp Leu Lys Met Pro Lys Val
785                 790                 795                 800 
Gln Tyr Lys Ser Asn Cys Lys Pro Ser Thr Phe Ala Tyr Pro Ala Pro
                805                 810                 815     
Leu Glu Val Pro Lys Glu Lys Glu Lys Glu Lys Val Ser Thr Ala Val
            820                 825                 830         
Leu Ser Ile Thr Ala Lys Ala Lys Lys Lys Glu Lys Glu Lys Glu Lys
        835                 840                 845             
Lys Glu Glu Glu Lys Met Glu Val Asp Glu Ala Glu Lys Lys Glu Glu
    850                 855                 860                 
Lys Glu Lys Lys Lys Glu Pro Glu Pro Asn Phe Gln Leu Leu Asp Asn
865                 870                 875                 880 
Pro Ala Arg Val Met Pro Ala Gln Leu Lys Val Leu Thr Met Pro Glu
                885                 890                 895     
Thr Cys Arg Tyr Gln Pro Phe Lys Pro Leu Ser Ile Gly Gly Ile Ile
            900                 905                 910         
Ile Leu Lys Asp Thr Ser Glu Asp Ile Glu Glu Leu Val Glu Pro Val
        915                 920                 925             
Ala Ala His Gly Pro Lys Ile Glu Glu Glu Glu Gln Glu Pro Glu Pro
    930                 935                 940                 
Pro Glu Pro Phe Glu Tyr Ile Asp Asp
945                 950             


<210> 1672
<211> 407
<212> PRT
<213> Homo sapiens

<400> 1672
Met Gln Gln Lys Ala Phe Glu Glu Ser Arg Tyr Pro Trp Gln Glu Ser
 1               5                  10                  15      
Phe Glu Asn Val Ala Val Cys Leu Pro Leu Arg Cys Pro Arg Cys Gly
            20                  25                  30          
Asp His Thr Arg Phe Arg Ser Leu Ser Ser Leu Arg Ala His Leu Glu
        35                  40                  45              
Phe Ser His Ser Tyr Glu Glu Arg Thr Leu Leu Thr Lys Cys Ser Leu
    50                  55                  60                  
Phe Pro Ser Leu Lys Asp Thr Asp Leu Val Thr Ser Ser Glu Leu Leu
65                  70                  75                  80  
Lys Pro Gly Lys Leu Gln Ser Ser Gly Asn Val Val Lys Gln Lys Pro
                85                  90                  95      
Ser Tyr Val Asn Leu Tyr Ser Ile Ser His Glu His Ser Lys Asp Arg
            100                 105                 110         
Lys Pro Phe Glu Val Val Ala Glu Arg Pro Val Ser Tyr Val Gln Thr
        115                 120                 125             
Tyr Thr Ala Met Asp Leu His Ala Asp Ser Leu Asp Gly Thr Arg Ser
    130                 135                 140                 
Gly Pro Gly Leu Pro Thr Ser Asp Thr Lys Ala Ser Phe Glu Ala His
145                 150                 155                 160 
Val Arg Glu Lys Phe Asn Arg Met Val Glu Ala Val Asp Arg Thr Ile
                165                 170                 175     
Glu Lys Arg Ile Asp Lys Leu Thr Lys Glu Leu Ala Gln Lys Thr Ala
            180                 185                 190         
Glu Leu Leu Glu Val Arg Ala Ala Phe Val Gln Leu Thr Gln Lys Lys
        195                 200                 205             
Gln Glu Val Gln Arg Arg Glu Arg Ala Leu Asn Arg Gln Val Asp Val
    210                 215                 220                 
Ala Val Glu Met Ile Ala Val Leu Arg Gln Arg Leu Thr Glu Ser Glu
225                 230                 235                 240 
Glu Glu Leu Leu Arg Lys Glu Glu Glu Val Val Thr Phe Asn His Phe
                245                 250                 255     
Leu Glu Ala Ala Ala Glu Lys Glu Val Gln Gly Lys Ala Arg Leu Gln
            260                 265                 270         
Asp Phe Ile Glu Asn Leu Leu Gln Arg Val Glu Leu Ala Glu Lys Gln
        275                 280                 285             
Leu Glu Tyr Tyr Gln Ser Gln Gln Ala Ser Gly Phe Val Arg Asp Leu
    290                 295                 300                 
Ser Gly His Val Leu Thr Asp Ile Ser Ser Asn Arg Lys Pro Lys Cys
305                 310                 315                 320 
Leu Ser Arg Gly His Pro His Ser Val Cys Asn His Pro Asp Leu Lys
                325                 330                 335     
Ala His Phe His Pro Lys Gly Arg Asn His Leu Lys Lys Ala Lys Asp
            340                 345                 350         
Asp Arg Ala Ser Met Gln Pro Ala Lys Ala Ile His Glu Gln Ala Glu
        355                 360                 365             
Ser Ser Arg Asp Leu Cys Arg Pro Pro Lys Lys Gly Glu Leu Leu Gly
    370                 375                 380                 
Phe Gly Arg Lys Gly Asn Ile Arg Pro Lys Met Ala Lys Lys Lys Pro
385                 390                 395                 400 
Thr Ala Ile Val Asn Ile Ile
                405         


<210> 1673
<211> 526
<212> PRT
<213> Homo sapiens

<400> 1673
Met Ala Val Phe Pro Ser Ser Gly Leu Pro Arg Cys Leu Leu Thr Leu
 1               5                  10                  15      
Ile Leu Leu Gln Leu Pro Lys Leu Asp Ser Ala Pro Phe Asp Val Ile
            20                  25                  30          
Gly Pro Pro Glu Pro Ile Leu Ala Val Val Gly Glu Asp Ala Glu Leu
        35                  40                  45              
Pro Cys Arg Leu Ser Pro Asn Ala Ser Ala Glu His Leu Glu Leu Arg
    50                  55                  60                  
Trp Phe Arg Lys Lys Val Ser Pro Ala Val Leu Val His Arg Asp Gly
65                  70                  75                  80  
Arg Glu Gln Glu Ala Glu Gln Met Pro Glu Tyr Arg Gly Arg Ala Thr
                85                  90                  95      
Leu Val Gln Asp Gly Ile Ala Lys Gly Arg Val Ala Leu Arg Ile Arg
            100                 105                 110         
Gly Val Arg Val Ser Asp Asp Gly Glu Tyr Thr Cys Phe Phe Arg Glu
        115                 120                 125             
Asp Gly Ser Tyr Glu Glu Ala Leu Val His Leu Lys Val Ala Ala Leu
    130                 135                 140                 
Gly Ser Asp Pro His Ile Ser Met Gln Val Gln Glu Asn Gly Glu Ile
145                 150                 155                 160 
Cys Leu Glu Cys Thr Ser Val Gly Trp Tyr Pro Glu Pro Gln Val Gln
                165                 170                 175     
Trp Arg Thr Ser Lys Gly Glu Lys Phe Pro Ser Thr Ser Glu Ser Arg
            180                 185                 190         
Asn Pro Asp Glu Glu Gly Leu Phe Thr Val Ala Ala Ser Val Ile Ile
        195                 200                 205             
Arg Asp Thr Ser Ala Lys Asn Val Ser Cys Tyr Ile Gln Asn Leu Leu
    210                 215                 220                 
Leu Gly Gln Glu Lys Lys Val Glu Ile Ser Ile Pro Ala Ser Ser Leu
225                 230                 235                 240 
Pro Arg Leu Thr Pro Trp Ile Val Ala Val Ala Val Ile Leu Met Val
                245                 250                 255     
Leu Gly Leu Leu Thr Ile Gly Ser Ile Phe Phe Thr Trp Arg Leu Tyr
            260                 265                 270         
Asn Glu Arg Pro Arg Glu Arg Arg Asn Glu Phe Ser Ser Lys Glu Arg
        275                 280                 285             
Leu Leu Glu Glu Leu Lys Trp Lys Lys Ala Thr Leu His Ala Val Asp
    290                 295                 300                 
Val Thr Leu Asp Pro Asp Thr Ala His Pro His Leu Phe Leu Tyr Glu
305                 310                 315                 320 
Asp Ser Lys Ser Val Arg Leu Glu Asp Ser Arg Gln Lys Leu Pro Glu
                325                 330                 335     
Lys Thr Glu Arg Phe Asp Ser Trp Pro Cys Val Leu Gly Arg Glu Thr
            340                 345                 350         
Phe Thr Ser Gly Arg His Tyr Trp Glu Val Glu Val Gly Asp Arg Thr
        355                 360                 365             
Asp Trp Ala Ile Gly Val Cys Arg Glu Asn Val Met Lys Lys Gly Phe
    370                 375                 380                 
Asp Pro Met Thr Pro Glu Asn Gly Phe Trp Ala Val Glu Leu Tyr Gly
385                 390                 395                 400 
Asn Gly Tyr Trp Ala Leu Thr Pro Leu Arg Thr Pro Leu Pro Leu Ala
                405                 410                 415     
Gly Pro Pro Arg Arg Val Gly Ile Phe Leu Asp Tyr Glu Ser Gly Asp
            420                 425                 430         
Ile Ser Phe Tyr Asn Met Asn Asp Gly Ser Asp Ile Tyr Thr Phe Ser
        435                 440                 445             
Asn Val Thr Phe Ser Gly Pro Leu Arg Pro Phe Phe Cys Leu Trp Ser
    450                 455                 460                 
Ser Gly Lys Lys Pro Leu Thr Ile Cys Pro Ile Ala Asp Gly Pro Glu
465                 470                 475                 480 
Arg Val Thr Val Ile Ala Asn Ala Gln Asp Leu Ser Lys Glu Ile Pro
                485                 490                 495     
Leu Ser Pro Met Gly Glu Asp Ser Ala Pro Arg Asp Ala Asp Thr Leu
            500                 505                 510         
His Ser Lys Leu Ile Pro Thr Gln Pro Ser Gln Gly Ala Pro
        515                 520                 525     


<210> 1674
<211> 2060
<212> PRT
<213> Homo sapiens

<400> 1674
Met Gly Lys Gln Thr Gly Ala Val Arg Pro Gln Glu Phe Arg Cys Leu
 1               5                  10                  15      
Asn Arg Ser Ala Ala Gly Ile Ala Ala Thr Ala Gly Phe Thr Asp Ala
            20                  25                  30          
Cys Leu Gln Pro Ala Glu Thr Thr Pro Ser Ser Pro Arg Asp Thr Pro
        35                  40                  45              
Leu Val Pro Ser Gly Val Lys Ser Trp Ala Gln Ala Ser Val Thr His
    50                  55                  60                  
Gly Ala His Gly Asp Gly Gly Arg Ala Ser Ser Leu Leu Ser Arg Phe
65                  70                  75                  80  
Ser Arg Glu Glu Phe Pro Thr Leu Gln Ala Ala Gly Asp Gln Asp Lys
                85                  90                  95      
Ala Ala Lys Glu Arg Glu Ser Ala Glu Gln Ser Ser Gly Pro Gly Pro
            100                 105                 110         
Ser Leu Arg Pro Gln Asn Ser Thr Thr Trp Arg Asp Gly Gly Gly Arg
        115                 120                 125             
Gly Pro Asp Glu Leu Glu Gly Pro Asp Ser Lys Leu His His Gly His
    130                 135                 140                 
Asp Pro Arg Gly Gly Leu Gln Pro Ser Gly Pro Pro Gln Phe Pro Pro
145                 150                 155                 160 
Tyr Arg Gly Met Met Pro Pro Phe Met Tyr Pro Pro Tyr Leu Pro Phe
                165                 170                 175     
Pro Pro Pro Tyr Gly Pro Gln Gly Pro Tyr Arg Tyr Pro Thr Pro Asp
            180                 185                 190         
Gly Pro Ser Arg Phe Pro Arg Val Ala Gly Pro Arg Gly Ser Gly Pro
        195                 200                 205             
Pro Met Arg Leu Val Glu Pro Val Gly Arg Pro Ser Ile Leu Lys Glu
    210                 215                 220                 
Asp Asn Leu Lys Glu Phe Asp Gln Leu Asp Gln Glu Asn Asp Asp Gly
225                 230                 235                 240 
Trp Ala Gly Ala His Glu Glu Val Asp Tyr Thr Glu Lys Leu Lys Phe
                245                 250                 255     
Ser Asp Glu Glu Asp Gly Arg Asp Ser Asp Glu Glu Gly Ala Glu Gly
            260                 265                 270         
His Arg Asp Ser Gln Ser Ala Ser Gly Glu Glu Arg Pro Pro Glu Ala
        275                 280                 285             
Asp Gly Lys Lys Gly Asn Ser Pro Asn Ser Glu Pro Pro Thr Pro Lys
    290                 295                 300                 
Thr Ala Trp Ala Glu Thr Ser Arg Pro Pro Glu Thr Glu Pro Gly Pro
305                 310                 315                 320 
Pro Ala Pro Lys Pro Pro Leu Pro Pro Gly Asp Tyr Pro Asp Arg Gly
                325                 330                 335     
Gly Pro Pro Cys Lys Pro Pro Ala Pro Glu Asp Glu Asp Glu Ala Trp
            340                 345                 350         
Arg Gln Arg Arg Lys Gln Ser Ser Ser Glu Ile Ser Leu Ala Val Glu
        355                 360                 365             
Arg Ala Arg Arg Arg Arg Glu Glu Glu Glu Arg Arg Met Gln Glu Glu
    370                 375                 380                 
Arg Arg Ala Ala Cys Ala Glu Lys Leu Lys Arg Leu Asp Glu Lys Phe
385                 390                 395                 400 
Gly Ala Pro Asp Lys Arg Leu Lys Ala Glu Pro Ala Ala Pro Pro Ala
                405                 410                 415     
Ala Pro Ser Thr Pro Ala Pro Pro Pro Ala Val Pro Lys Glu Leu Pro
            420                 425                 430         
Ala Pro Pro Ala Pro Pro Pro Ala Ser Ala Pro Thr Pro Glu Lys Glu
        435                 440                 445             
Pro Glu Glu Pro Ala Gln Ala Pro Pro Ala Gln Ser Thr Pro Thr Pro
    450                 455                 460                 
Gly Val Ala Ala Ala Pro Thr Leu Val Ser Gly Gly Gly Ser Thr Ser
465                 470                 475                 480 
Ser Thr Ser Ser Gly Ser Phe Glu Ala Ser Pro Val Glu Pro Gln Leu
                485                 490                 495     
Pro Ser Lys Glu Gly Pro Glu Pro Pro Glu Glu Val Pro Pro Pro Thr
            500                 505                 510         
Thr Pro Pro Val Pro Lys Val Glu Pro Lys Gly Asp Gly Ile Gly Pro
        515                 520                 525             
Thr Arg Gln Pro Pro Ser Gln Gly Leu Gly Tyr Pro Lys Tyr Gln Lys
    530                 535                 540                 
Ser Leu Pro Pro Arg Phe Gln Arg Gln Gln Gln Glu Gln Leu Leu Lys
545                 550                 555                 560 
Gln Gln Gln Gln His Gln Trp Gln Gln His Gln Gln Gly Ser Ala Pro
                565                 570                 575     
Pro Thr Pro Val Pro Pro Ser Pro Pro Gln Pro Val Thr Leu Gly Ala
            580                 585                 590         
Val Pro Ala Pro Gln Ala Pro Pro Pro Pro Pro Lys Ala Leu Tyr Pro
        595                 600                 605             
Gly Ala Leu Gly Arg Pro Pro Pro Met Pro Pro Met Asn Phe Asp Pro
    610                 615                 620                 
Arg Trp Met Met Ile Pro Pro Tyr Val Asp Pro Arg Leu Leu Gln Gly
625                 630                 635                 640 
Arg Pro Pro Leu Asp Phe Tyr Pro Pro Gly Val His Pro Ser Gly Leu
                645                 650                 655     
Val Pro Arg Glu Arg Ser Asp Ser Gly Gly Ser Ser Ser Glu Pro Phe
            660                 665                 670         
Asp Arg His Ala Pro Ala Met Leu Arg Glu Arg Gly Thr Pro Pro Val
        675                 680                 685             
Asp Pro Lys Leu Ala Trp Val Gly Asp Val Phe Thr Ala Thr Pro Ala
    690                 695                 700                 
Glu Pro Arg Pro Leu Thr Ser Pro Leu Arg Gln Ala Ala Asp Glu Asp
705                 710                 715                 720 
Asp Lys Gly Met Arg Ser Glu Thr Pro Pro Val Pro Pro Pro Pro Pro
                725                 730                 735     
Tyr Leu Ala Ser Tyr Pro Gly Phe Pro Glu Asn Gly Ala Pro Gly Pro
            740                 745                 750         
Pro Ile Ser Arg Phe Pro Leu Glu Glu Pro Gly Pro Arg Pro Leu Pro
        755                 760                 765             
Trp Pro Pro Gly Ser Asp Glu Val Ala Lys Ile Gln Thr Pro Pro Pro
    770                 775                 780                 
Lys Lys Glu Pro Pro Lys Glu Glu Thr Ala Gln Leu Thr Gly Pro Glu
785                 790                 795                 800 
Ala Gly Arg Lys Pro Ala Arg Gly Val Gly Ser Gly Gly Gln Gly Pro
                805                 810                 815     
Pro Pro Pro Arg Arg Glu Ser Arg Thr Glu Thr Arg Trp Gly Pro Arg
            820                 825                 830         
Pro Gly Ser Ser Arg Arg Gly Ile Pro Pro Glu Glu Pro Gly Ala Pro
        835                 840                 845             
Pro Arg Arg Ala Gly Pro Ile Lys Lys Pro Pro Pro Pro Thr Lys Val
    850                 855                 860                 
Glu Glu Leu Pro Pro Lys Pro Leu Glu Gln Gly Asp Glu Thr Pro Lys
865                 870                 875                 880 
Pro Pro Lys Pro Asp Pro Leu Lys Ile Thr Lys Gly Lys Leu Gly Gly
                885                 890                 895     
Pro Lys Glu Thr Pro Pro Asn Gly Asn Leu Ser Pro Ala Pro Arg Leu
            900                 905                 910         
Arg Arg Asp Tyr Ser Tyr Glu Arg Val Gly Pro Thr Ser Cys Arg Gly
        915                 920                 925             
Arg Gly Arg Gly Glu Tyr Phe Ala Arg Gly Arg Gly Phe Arg Gly Thr
    930                 935                 940                 
Tyr Gly Gly Arg Gly Arg Gly Ala Arg Ser Arg Glu Phe Arg Ser Tyr
945                 950                 955                 960 
Arg Glu Phe Arg Gly Asp Asp Gly Arg Gly Gly Gly Thr Gly Gly Pro
                965                 970                 975     
Asn His Pro Pro Ala Pro Arg Gly Arg Thr Ala Ser Glu Thr Arg Ser
            980                 985                 990         
Glu Gly Ser Glu Tyr Glu Glu Ile Pro Lys Arg Arg Arg Gln Arg Gly
        995                 1000                1005            
Ser Glu Thr Gly Ser Glu Thr His Glu Ser Asp Leu Ala Pro Ser Asp
    1010                1015                1020                
Lys Glu Ala Pro Thr Pro Lys Glu Gly Thr Leu Thr Gln Val Pro Leu
1025                1030                1035                1040
Ala Pro Pro Pro Pro Gly Ala Pro Pro Ser Pro Ala Pro Ala Arg Phe
                1045                1050                1055    
Thr Ala Arg Gly Gly Arg Val Phe Thr Pro Arg Gly Val Pro Ser Arg
            1060                1065                1070        
Arg Gly Arg Gly Gly Gly Arg Pro Pro Pro Gln Val Cys Pro Gly Trp
        1075                1080                1085            
Ser Pro Pro Ala Lys Ser Leu Ala Pro Lys Lys Pro Pro Thr Gly Pro
    1090                1095                1100                
Leu Pro Pro Ser Lys Glu Pro Leu Lys Glu Lys Leu Ile Pro Gly Pro
1105                1110                1115                1120
Leu Ser Pro Val Ala Arg Gly Gly Ser Asn Gly Gly Ser Asn Val Gly
                1125                1130                1135    
Met Glu Asp Gly Glu Arg Pro Arg Arg Arg Arg His Gly Arg Ala Gln
            1140                1145                1150        
Gln Gln Asp Lys Pro Pro Arg Phe Arg Arg Leu Lys Gln Glu Arg Glu
        1155                1160                1165            
Asn Ala Ala Arg Gly Ser Glu Gly Lys Pro Ser Leu Thr Leu Pro Ala
    1170                1175                1180                
Ser Ala Pro Ala Pro Glu Glu Ala Leu Thr Thr Val Thr Val Ala Pro
1185                1190                1195                1200
Ala Pro Arg Arg Ala Ala Ala Lys Ser Pro Asp Leu Ser Asn Gln Asn
                1205                1210                1215    
Ser Asp Gln Ala Asn Glu Glu Trp Glu Thr Ala Ser Glu Ser Ser Asp
            1220                1225                1230        
Phe Thr Ser Glu Arg Arg Gly Asp Lys Glu Ala Pro Pro Pro Val Leu
        1235                1240                1245            
Leu Thr Pro Lys Ala Val Gly Thr Pro Gly Gly Gly Gly Gly Gly Ala
    1250                1255                1260                
Val Pro Gly Ile Ser Ala Met Ser Arg Gly Asp Leu Ser Gln Arg Ala
1265                1270                1275                1280
Lys Asp Leu Ser Lys Arg Ser Phe Ser Ser Gln Arg Pro Gly Met Glu
                1285                1290                1295    
Arg Gln Asn Arg Arg Pro Gly Pro Gly Gly Lys Ala Gly Ser Ser Gly
            1300                1305                1310        
Ser Ser Ser Gly Gly Gly Gly Gly Gly Pro Gly Gly Arg Thr Gly Pro
        1315                1320                1325            
Gly Arg Gly Asp Lys Arg Ser Trp Pro Ser Pro Lys Asn Arg Ser Arg
    1330                1335                1340                
Pro Pro Glu Glu Arg Pro Pro Gly Leu Pro Leu Pro Pro Pro Pro Pro
1345                1350                1355                1360
Ser Ser Ser Ala Val Phe Arg Leu Asp Gln Val Ile His Ser Asn Pro
                1365                1370                1375    
Ala Gly Ile Gln Gln Ala Leu Ala Gln Leu Ser Ser Arg Gln Gly Ser
            1380                1385                1390        
Val Thr Ala Pro Gly Gly His Pro Arg His Lys Pro Gly Pro Pro Gln
        1395                1400                1405            
Ala Pro Gln Gly Pro Ser Pro Arg Pro Pro Thr Arg Tyr Glu Pro Gln
    1410                1415                1420                
Arg Val Asn Ser Gly Leu Ser Ser Asp Pro His Phe Glu Glu Pro Gly
1425                1430                1435                1440
Pro Met Val Arg Gly Val Gly Gly Thr Pro Arg Asp Ser Ala Gly Val
                1445                1450                1455    
Ser Pro Phe Pro Pro Lys Arg Arg Glu Arg Pro Pro Arg Lys Pro Glu
            1460                1465                1470        
Leu Leu Gln Glu Glu Ser Leu Pro Pro Pro His Ser Ser Gly Phe Leu
        1475                1480                1485            
Gly Ser Lys Pro Glu Gly Pro Gly Pro Gln Ala Glu Ser Arg Asp Thr
    1490                1495                1500                
Gly Thr Glu Ala Leu Thr Pro His Ile Trp Asn Arg Leu His Thr Ala
1505                1510                1515                1520
Thr Ser Arg Lys Ser Tyr Arg Pro Ser Ser Met Glu Pro Trp Met Glu
                1525                1530                1535    
Pro Leu Ser Pro Phe Glu Asp Val Ala Gly Thr Glu Met Ser Gln Ser
            1540                1545                1550        
Asp Ser Gly Val Asp Leu Ser Gly Asp Ser Gln Val Ser Ser Gly Pro
        1555                1560                1565            
Cys Ser Gln Arg Ser Ser Pro Asp Gly Gly Leu Lys Gly Ala Ala Glu
    1570                1575                1580                
Gly Pro Pro Lys Arg Pro Gly Gly Ser Ser Pro Leu Asn Ala Val Pro
1585                1590                1595                1600
Cys Glu Gly Pro Pro Gly Ser Glu Pro Pro Arg Arg Pro Pro Pro Ala
                1605                1610                1615    
Pro His Asp Gly Asp Arg Lys Glu Leu Pro Arg Glu Gln Pro Leu Pro
            1620                1625                1630        
Pro Gly Pro Ile Gly Thr Glu Arg Ser Gln His Thr Asp Arg Gly Thr
        1635                1640                1645            
Glu Pro Gly Pro Ile Arg Pro Ser His Arg Pro Gly Pro Pro Val Gln
    1650                1655                1660                
Phe Gly Thr Ser Asp Lys Asp Ser Asp Leu Arg Leu Val Val Gly Asp
1665                1670                1675                1680
Ser Leu Lys Ala Glu Lys Glu Leu Thr Ala Ser Val Thr Glu Ala Ile
                1685                1690                1695    
Pro Val Ser Arg Asp Trp Glu Leu Leu Pro Ser Ala Ala Ala Ser Ala
            1700                1705                1710        
Glu Pro Gln Ser Lys Asn Leu Asp Ser Gly His Cys Val Pro Glu Pro
        1715                1720                1725            
Ser Ser Ser Gly Gln Arg Leu Tyr Pro Glu Val Phe Tyr Gly Ser Ala
    1730                1735                1740                
Gly Pro Ser Ser Ser Gln Ile Ser Gly Gly Ala Met Asp Ser Gln Leu
1745                1750                1755                1760
His Pro Asn Ser Gly Gly Phe Arg Pro Gly Thr Pro Ser Leu His Pro
                1765                1770                1775    
Tyr Arg Ser Gln Pro Leu Tyr Leu Pro Pro Gly Pro Ala Pro Pro Ser
            1780                1785                1790        
Ala Leu Leu Ser Gly Val Ala Leu Lys Gly Gln Phe Leu Asp Phe Ser
        1795                1800                1805            
Thr Met Gln Ala Thr Glu Leu Gly Lys Leu Pro Ala Gly Gly Val Leu
    1810                1815                1820                
Tyr Pro Pro Pro Ser Phe Leu Tyr Ser Pro Ala Phe Cys Pro Ser Pro
1825                1830                1835                1840
Leu Pro Asp Thr Ser Leu Leu Gln Val Arg Gln Asp Leu Pro Ser Pro
                1845                1850                1855    
Ser Asp Phe Tyr Ser Thr Pro Leu Gln Pro Gly Gly Gln Ser Gly Phe
            1860                1865                1870        
Leu Pro Ser Gly Ala Pro Ala Gln Gln Met Leu Leu Pro Met Val Asp
        1875                1880                1885            
Ser Gln Leu Pro Val Val Asn Phe Gly Ser Leu Pro Pro Ala Pro Pro
    1890                1895                1900                
Pro Ala Pro Pro Pro Leu Ser Leu Leu Pro Val Gly Pro Ala Leu Gln
1905                1910                1915                1920
Pro Pro Ser Leu Ala Val Arg Pro Pro Pro Ala Pro Ala Thr Arg Val
                1925                1930                1935    
Leu Pro Ser Pro Ala Arg Pro Phe Pro Ala Ser Leu Gly Arg Ala Glu
            1940                1945                1950        
Leu His Pro Val Glu Leu Lys Pro Phe Gln Asp Tyr Gln Lys Leu Ser
        1955                1960                1965            
Ser Asn Leu Gly Gly Pro Gly Ser Ser Arg Thr Pro Pro Thr Gly Arg
    1970                1975                1980                
Ser Phe Ser Gly Leu Asn Ser Arg Leu Lys Ala Thr Pro Ser Thr Tyr
1985                1990                1995                2000
Ser Gly Val Phe Arg Thr Gln Arg Val Asp Leu Tyr Gln Gln Ala Ser
                2005                2010                2015    
Pro Pro Asp Ala Leu Arg Trp Ile Pro Lys Pro Trp Glu Arg Thr Gly
            2020                2025                2030        
Leu Pro Pro Arg Glu Gly Pro Ser Arg Arg Ala Glu Glu Pro Gly Ser
        2035                2040                2045            
Arg Gly Asp Lys Glu Pro Gly Leu Pro Pro Pro Arg
    2050                2055                2060


<210> 1675
<211> 641
<212> PRT
<213> Homo sapiens

<400> 1675
Met Ala Thr Ala Lys Gly Ile Ala Ile Gly Ile Asp Leu Gly Thr Thr
 1               5                  10                  15      
Tyr Ser Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala
            20                  25                  30          
Asn Asp Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp
        35                  40                  45              
Thr Glu Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Met Asn
    50                  55                  60                  
Pro Gln Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe
65                  70                  75                  80  
Asn Asp Pro Val Val Gln Ala Asp Met Lys Leu Trp Pro Phe Gln Val
                85                  90                  95      
Ile Asn Glu Gly Gly Lys Pro Lys Val Leu Val Ser Tyr Lys Gly Glu
            100                 105                 110         
Asn Lys Ala Phe Tyr Pro Glu Glu Ile Ser Ser Met Val Leu Thr Lys
        115                 120                 125             
Leu Lys Glu Thr Ala Glu Ala Phe Leu Gly His Pro Val Thr Asn Ala
    130                 135                 140                 
Val Ile Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr
145                 150                 155                 160 
Lys Asp Ala Gly Val Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn
                165                 170                 175     
Glu Pro Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Lys Gly Gly Gln
            180                 185                 190         
Gly Glu Arg His Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp
        195                 200                 205             
Val Ser Ile Leu Thr Ile Asp Asp Gly Ile Phe Glu Val Lys Ala Thr
    210                 215                 220                 
Ala Gly Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val
225                 230                 235                 240 
Ser His Phe Val Glu Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser
                245                 250                 255     
Gln Asn Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala
            260                 265                 270         
Lys Arg Thr Leu Ser Ser Ser Thr Gln Ala Asn Leu Glu Ile Asp Ser
        275                 280                 285             
Leu Tyr Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe
    290                 295                 300                 
Glu Glu Leu Cys Ala Asp Leu Phe Arg Gly Thr Leu Glu Pro Val Glu
305                 310                 315                 320 
Lys Ala Leu Arg Asp Ala Lys Met Asp Lys Ala Lys Ile His Asp Ile
                325                 330                 335     
Val Leu Val Gly Gly Ser Thr Arg Ile Pro Lys Val Gln Arg Leu Leu
            340                 345                 350         
Gln Asp Tyr Phe Asn Gly Arg Asp Leu Asn Lys Ser Ile Asn Pro Asp
        355                 360                 365             
Glu Ala Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Met Gly
    370                 375                 380                 
Asp Lys Ser Glu Lys Val Gln Asp Leu Leu Leu Leu Asp Val Ala Pro
385                 390                 395                 400 
Leu Ser Leu Gly Leu Glu Thr Ala Gly Gly Val Met Thr Ala Leu Ile
                405                 410                 415     
Lys Arg Asn Ser Thr Ile Pro Thr Lys Gln Thr Gln Ile Phe Thr Thr
            420                 425                 430         
Tyr Ser Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu
        435                 440                 445             
Arg Ala Met Thr Lys Asp Asn Asn Leu Leu Gly Arg Phe Asp Leu Thr
    450                 455                 460                 
Gly Ile Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe
465                 470                 475                 480 
Asp Ile Asp Ala Asn Gly Ile Leu Asn Val Thr Ala Met Asp Lys Ser
                485                 490                 495     
Thr Gly Lys Val Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu
            500                 505                 510         
Ser Lys Glu Glu Ile Glu Arg Met Val Leu Asp Ala Glu Lys Tyr Lys
        515                 520                 525             
Ala Glu Asp Glu Val Gln Arg Glu Lys Ile Ala Ala Lys Asn Ala Leu
    530                 535                 540                 
Glu Ser Tyr Ala Phe Asn Met Lys Ser Val Val Ser Asp Glu Gly Leu
545                 550                 555                 560 
Lys Gly Lys Ile Ser Glu Ser Asp Lys Asn Lys Ile Leu Asp Lys Cys
                565                 570                 575     
Asn Glu Leu Leu Ser Trp Leu Glu Val Asn Gln Leu Ala Glu Lys Asp
            580                 585                 590         
Glu Phe Asp His Lys Arg Lys Glu Leu Glu Gln Met Cys Asn Pro Ile
        595                 600                 605             
Ile Thr Lys Leu Tyr Gln Gly Gly Cys Thr Gly Pro Ala Cys Gly Thr
    610                 615                 620                 
Gly Tyr Val Pro Gly Arg Pro Ala Thr Gly Pro Thr Ile Glu Glu Val
625                 630                 635                 640 
Asp
    


<210> 1676
<211> 532
<212> PRT
<213> Homo sapiens

<400> 1676
Met Glu Asp Gly Leu Ile Lys Gln Ile Gly Asp Asn Leu Ile Val Pro
 1               5                  10                  15      
Gly Gly Val Lys Thr Ile Glu Ala Asn Gly Lys Met Val Ile Pro Gly
            20                  25                  30          
Gly Ile Asp Val His Thr His Phe Gln Met Pro Tyr Lys Gly Met Thr
        35                  40                  45              
Thr Val Asp Asp Phe Phe Gln Gly Thr Lys Ala Ala Leu Ala Gly Gly
    50                  55                  60                  
Thr Thr Met Ile Ile Asp His Val Val Pro Glu Pro Glu Ser Ser Leu
65                  70                  75                  80  
Thr Glu Ala Tyr Glu Lys Trp Arg Glu Trp Ala Asp Gly Lys Ser Cys
                85                  90                  95      
Cys Asp Tyr Ala Leu His Val Asp Ile Thr His Trp Asn Asp Ser Val
            100                 105                 110         
Lys Gln Glu Val Gln Asn Leu Ile Lys Asp Lys Gly Val Asn Ser Phe
        115                 120                 125             
Met Val Tyr Met Ala Tyr Lys Asp Leu Tyr Gln Val Ser Asn Thr Glu
    130                 135                 140                 
Leu Tyr Glu Ile Phe Thr Cys Leu Gly Glu Leu Gly Ala Ile Ala Gln
145                 150                 155                 160 
Val His Ala Glu Asn Gly Asp Ile Ile Ala Gln Glu Gln Thr Arg Met
                165                 170                 175     
Leu Glu Met Gly Ile Thr Gly Pro Glu Gly His Val Leu Ser Arg Pro
            180                 185                 190         
Glu Glu Leu Glu Ala Glu Ala Val Phe Arg Ala Ile Thr Ile Ala Ser
        195                 200                 205             
Gln Thr Asn Cys Pro Leu Tyr Val Thr Lys Val Met Ser Lys Ser Ala
    210                 215                 220                 
Ala Asp Leu Ile Ser Gln Ala Arg Lys Lys Gly Asn Val Val Phe Gly
225                 230                 235                 240 
Glu Pro Ile Thr Ala Ser Leu Gly Ile Asp Gly Thr His Tyr Trp Ser
                245                 250                 255     
Lys Asn Trp Ala Lys Ala Ala Ala Phe Val Thr Ser Pro Pro Leu Ser
            260                 265                 270         
Pro Asp Pro Thr Thr Pro Asp Tyr Ile Asn Ser Leu Leu Ala Ser Gly
        275                 280                 285             
Asp Leu Gln Leu Ser Gly Ser Ala His Cys Thr Phe Ser Thr Ala Gln
    290                 295                 300                 
Lys Ala Ile Gly Lys Asp Asn Phe Thr Ala Ile Pro Glu Gly Thr Asn
305                 310                 315                 320 
Gly Val Glu Glu Arg Met Ser Val Ile Trp Asp Lys Ala Val Ala Thr
                325                 330                 335     
Gly Lys Met Asp Glu Asn Gln Phe Val Ala Val Thr Ser Thr Asn Ala
            340                 345                 350         
Ala Lys Ile Phe Asn Leu Tyr Pro Arg Lys Gly Arg Ile Ser Val Gly
        355                 360                 365             
Ser Asp Ser Asp Leu Val Ile Trp Asp Pro Asp Ala Val Lys Ile Val
    370                 375                 380                 
Ser Ala Lys Asn His Gln Ser Ala Ala Glu Tyr Asn Ile Phe Glu Gly
385                 390                 395                 400 
Met Glu Leu Arg Gly Ala Pro Leu Val Val Ile Cys Gln Gly Lys Ile
                405                 410                 415     
Met Leu Glu Asp Gly Asn Leu His Val Thr Gln Gly Ala Gly Arg Phe
            420                 425                 430         
Ile Pro Cys Ser Pro Phe Ser Asp Tyr Val Tyr Lys Arg Ile Lys Ala
        435                 440                 445             
Arg Arg Lys Met Ala Asp Leu His Ala Val Pro Arg Gly Met Tyr Asp
    450                 455                 460                 
Gly Pro Val Phe Asp Leu Thr Thr Thr Pro Lys Gly Gly Thr Pro Ala
465                 470                 475                 480 
Gly Ser Ala Arg Gly Ser Pro Thr Arg Pro Asn Pro Pro Val Arg Asn
                485                 490                 495     
Leu His Gln Ser Gly Phe Ser Leu Ser Ala Pro Lys Trp Met Arg Gly
            500                 505                 510         
Phe Ala Gln Pro Ala Ser Ala Ser Trp Arg Pro Gln Ala Ala Val Leu
        515                 520                 525             
Ile Ser His Leu
    530         


<210> 1677
<211> 419
<212> PRT
<213> Homo sapiens

<400> 1677
Met Ala Ser Ile Phe Ser Lys Leu Leu Thr Gly Arg Asn Ala Ser Leu
 1               5                  10                  15      
Leu Phe Ala Thr Met Gly Thr Ser Val Leu Thr Thr Gly Tyr Leu Leu
            20                  25                  30          
Asn Arg Gln Lys Val Cys Ala Glu Val Arg Glu Gln Pro Arg Leu Phe
        35                  40                  45              
Pro Pro Ser Ala Asp Tyr Pro Asp Leu Arg Lys His Asn Asn Cys Met
    50                  55                  60                  
Ala Glu Cys Leu Thr Pro Ala Ile Tyr Ala Lys Leu Arg Asn Lys Val
65                  70                  75                  80  
Thr Pro Asn Gly Tyr Thr Leu Asp Gln Cys Ile Gln Thr Gly Val Asp
                85                  90                  95      
Asn Pro Gly His Pro Phe Ile Lys Thr Val Gly Met Val Ala Gly Asp
            100                 105                 110         
Glu Glu Ser Tyr Glu Val Phe Ala Asp Leu Phe Asp Pro Val Ile Lys
        115                 120                 125             
Leu Arg His Asn Gly Tyr Asp Pro Arg Val Met Lys His Thr Thr Asp
    130                 135                 140                 
Leu Asp Ala Ser Lys Ile Thr Gln Gly Gln Phe Asp Glu His Tyr Val
145                 150                 155                 160 
Leu Ser Ser Arg Val Arg Thr Gly Arg Ser Ile Arg Gly Leu Ser Leu
                165                 170                 175     
Pro Pro Ala Cys Thr Arg Ala Glu Arg Arg Glu Val Glu Asn Val Ala
            180                 185                 190         
Ile Thr Ala Leu Glu Gly Leu Lys Gly Asp Leu Ala Gly Arg Tyr Tyr
        195                 200                 205             
Lys Leu Ser Glu Met Thr Glu Gln Asp Gln Gln Arg Leu Ile Asp Asp
    210                 215                 220                 
His Phe Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Thr Cys Ala Gly
225                 230                 235                 240 
Met Ala Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Tyr Asp
                245                 250                 255     
Lys Thr Phe Leu Ile Trp Ile Asn Glu Glu Asp His Thr Arg Val Ile
            260                 265                 270         
Ser Met Glu Lys Gly Gly Asn Met Lys Arg Val Phe Glu Arg Phe Cys
        275                 280                 285             
Arg Gly Leu Lys Glu Val Glu Arg Leu Ile Gln Glu Arg Gly Trp Glu
    290                 295                 300                 
Phe Met Trp Asn Glu Arg Leu Gly Tyr Ile Leu Thr Cys Pro Ser Asn
305                 310                 315                 320 
Leu Gly Thr Gly Leu Arg Ala Gly Val His Val Arg Ile Pro Lys Leu
                325                 330                 335     
Ser Lys Asp Pro Arg Phe Ser Lys Ile Leu Glu Asn Leu Arg Leu Gln
            340                 345                 350         
Lys Arg Gly Thr Gly Gly Val Asp Thr Ala Ala Val Ala Asp Val Tyr
        355                 360                 365             
Asp Ile Ser Asn Ile Asp Arg Ile Gly Arg Ser Glu Val Glu Leu Val
    370                 375                 380                 
Gln Ile Val Ile Asp Gly Val Asn Tyr Leu Val Asp Cys Glu Lys Lys
385                 390                 395                 400 
Leu Glu Arg Gly Gln Asp Ile Lys Val Pro Pro Pro Leu Pro Gln Phe
                405                 410                 415     
Gly Lys Lys
            


<210> 1678
<211> 244
<212> PRT
<213> Homo sapiens

<400> 1678
Met Ala Ala Ala Ala Ala Ala Gly Glu Ala Arg Arg Val Leu Val Tyr
 1               5                  10                  15      
Gly Gly Arg Gly Ala Leu Gly Ser Arg Cys Val Gln Ala Phe Arg Ala
            20                  25                  30          
Arg Asn Trp Trp Val Ala Ser Val Asp Val Val Glu Asn Glu Glu Ala
        35                  40                  45              
Ser Ala Ser Ile Ile Val Lys Met Thr Asp Ser Phe Thr Glu Gln Ala
    50                  55                  60                  
Asp Gln Val Thr Ala Glu Val Gly Lys Leu Leu Gly Glu Glu Lys Val
65                  70                  75                  80  
Asp Ala Ile Leu Cys Val Ala Gly Gly Trp Ala Gly Gly Asn Ala Lys
                85                  90                  95      
Ser Lys Ser Leu Phe Lys Asn Cys Asp Leu Met Trp Lys Gln Ser Ile
            100                 105                 110         
Trp Thr Ser Thr Ile Ser Ser His Leu Ala Thr Lys His Leu Lys Glu
        115                 120                 125             
Gly Gly Leu Leu Thr Leu Ala Gly Ala Lys Ala Ala Leu Asp Gly Thr
    130                 135                 140                 
Pro Gly Met Ile Gly Tyr Gly Met Ala Lys Gly Ala Val His Gln Leu
145                 150                 155                 160 
Cys Gln Ser Leu Ala Gly Lys Asn Ser Gly Met Pro Pro Gly Ala Ala
                165                 170                 175     
Ala Ile Ala Val Leu Pro Val Thr Leu Asp Thr Pro Met Asn Arg Lys
            180                 185                 190         
Ser Met Pro Glu Ala Asp Phe Ser Ser Trp Thr Pro Leu Glu Phe Leu
        195                 200                 205             
Val Glu Thr Phe His Asp Trp Ile Thr Gly Lys Asn Arg Pro Ser Ser
    210                 215                 220                 
Gly Ser Leu Ile Gln Val Val Thr Thr Glu Gly Arg Thr Glu Leu Thr
225                 230                 235                 240 
Pro Ala Tyr Phe
                


<210> 1679
<211> 314
<212> PRT
<213> Homo sapiens

<400> 1679
Met Ala Phe Val Thr Arg Gln Phe Met Arg Ser Val Ser Ser Ser Ser
 1               5                  10                  15      
Thr Ala Ser Ala Ser Ala Lys Lys Ile Ile Val Lys His Val Thr Val
            20                  25                  30          
Ile Gly Gly Gly Leu Met Gly Ala Gly Ile Ala Gln Val Ala Ala Ala
        35                  40                  45              
Thr Gly His Thr Val Val Leu Val Asp Gln Thr Glu Asp Ile Leu Ala
    50                  55                  60                  
Lys Ser Lys Lys Gly Ile Glu Glu Ser Leu Arg Lys Val Ala Lys Lys
65                  70                  75                  80  
Lys Phe Ala Glu Asn Pro Lys Ala Gly Asp Glu Phe Val Glu Lys Thr
                85                  90                  95      
Leu Ser Thr Ile Ala Thr Ser Thr Asp Ala Ala Ser Val Val His Ser
            100                 105                 110         
Thr Asp Leu Val Val Glu Ala Ile Val Glu Asn Leu Lys Val Lys Asn
        115                 120                 125             
Glu Leu Phe Lys Arg Leu Asp Lys Phe Ala Ala Glu His Thr Ile Phe
    130                 135                 140                 
Ala Ser Asn Thr Ser Ser Leu Gln Ile Thr Ser Ile Ala Asn Ala Thr
145                 150                 155                 160 
Thr Arg Gln Asp Arg Phe Ala Gly Leu His Phe Phe Asn Pro Val Pro
                165                 170                 175     
Val Met Lys Leu Val Glu Val Ile Lys Thr Pro Met Thr Ser Gln Lys
            180                 185                 190         
Thr Phe Glu Ser Leu Val Asp Phe Ser Lys Ala Leu Gly Lys His Pro
        195                 200                 205             
Val Ser Cys Lys Asp Thr Pro Gly Phe Ile Val Asn Arg Leu Leu Val
    210                 215                 220                 
Pro Tyr Leu Met Glu Ala Ile Arg Leu Tyr Glu Arg Gly Asp Ala Ser
225                 230                 235                 240 
Lys Glu Asp Ile Asp Thr Ala Met Lys Leu Gly Ala Gly Tyr Pro Met
                245                 250                 255     
Gly Pro Phe Glu Leu Leu Asp Tyr Val Gly Leu Asp Thr Thr Lys Phe
            260                 265                 270         
Ile Val Asp Gly Trp His Glu Met Asp Ala Glu Asn Pro Leu His Gln
        275                 280                 285             
Pro Ser Pro Ser Leu Asn Lys Leu Val Ala Glu Asn Lys Phe Gly Lys
    290                 295                 300                 
Lys Thr Gly Glu Gly Phe Tyr Lys Tyr Lys
305                 310                 


<210> 1680
<211> 298
<212> PRT
<213> Homo sapiens

<400> 1680
Met Gly Asp His Ala Trp Ser Phe Leu Lys Asp Phe Leu Ala Gly Gly
 1               5                  10                  15      
Val Ala Ala Ala Val Ser Lys Thr Ala Val Ala Pro Ile Glu Arg Val
            20                  25                  30          
Lys Leu Leu Leu Gln Val Gln His Ala Ser Lys Gln Ile Ser Ala Glu
        35                  40                  45              
Lys Gln Tyr Lys Gly Ile Ile Asp Cys Val Val Arg Ile Pro Lys Glu
    50                  55                  60                  
Gln Gly Phe Leu Ser Phe Trp Arg Gly Asn Leu Ala Asn Val Ile Arg
65                  70                  75                  80  
Tyr Phe Pro Thr Gln Ala Leu Asn Phe Ala Phe Lys Asp Lys Tyr Lys
                85                  90                  95      
Gln Leu Phe Leu Gly Gly Val Asp Arg His Lys Gln Phe Trp Arg Tyr
            100                 105                 110         
Phe Ala Gly Asn Leu Ala Ser Gly Gly Ala Ala Gly Ala Thr Ser Leu
        115                 120                 125             
Cys Phe Val Tyr Pro Leu Asp Phe Ala Arg Thr Arg Leu Ala Ala Asp
    130                 135                 140                 
Val Gly Lys Gly Ala Ala Gln Arg Glu Phe His Gly Leu Gly Asp Cys
145                 150                 155                 160 
Ile Ile Lys Ile Phe Lys Ser Asp Gly Leu Arg Gly Leu Tyr Gln Gly
                165                 170                 175     
Phe Asn Val Ser Val Gln Gly Ile Ile Ile Tyr Arg Ala Ala Tyr Phe
            180                 185                 190         
Gly Val Tyr Asp Thr Ala Lys Gly Met Leu Pro Asp Pro Lys Asn Val
        195                 200                 205             
His Ile Phe Val Ser Trp Met Ile Ala Gln Ser Val Thr Ala Val Ala
    210                 215                 220                 
Gly Leu Val Ser Tyr Pro Phe Asp Thr Val Arg Arg Arg Met Met Met
225                 230                 235                 240 
Gln Ser Gly Arg Lys Gly Ala Asp Ile Met Tyr Thr Gly Thr Val Asp
                245                 250                 255     
Cys Trp Arg Lys Ile Ala Lys Asp Glu Gly Ala Lys Ala Phe Phe Lys
            260                 265                 270         
Gly Ala Trp Ser Asn Val Leu Arg Gly Met Gly Gly Ala Phe Val Leu
        275                 280                 285             
Val Leu Tyr Asp Glu Ile Lys Lys Tyr Val
    290                 295             


<210> 1681
<211> 569
<212> PRT
<213> Homo sapiens

<400> 1681
Met Lys Lys Lys Leu Val Val Leu Gly Leu Leu Ala Val Val Leu Val
 1               5                  10                  15      
Leu Val Ile Val Gly Leu Cys Leu Trp Leu Pro Ser Ala Ser Lys Glu
            20                  25                  30          
Pro Asp Asn His Val Tyr Thr Arg Ala Ala Val Ala Ala Asp Ala Lys
        35                  40                  45              
Gln Cys Ser Lys Ile Gly Arg Asp Ala Leu Arg Asp Gly Gly Ser Ala
    50                  55                  60                  
Val Asp Ala Ala Ile Ala Ala Leu Leu Cys Val Gly Leu Met Asn Ala
65                  70                  75                  80  
His Ser Met Gly Ile Gly Gly Gly Leu Phe Leu Thr Ile Tyr Asn Ser
                85                  90                  95      
Thr Thr Arg Lys Ala Glu Val Ile Asn Ala Arg Glu Val Ala Pro Arg
            100                 105                 110         
Leu Ala Phe Ala Thr Met Phe Asn Ser Ser Glu Gln Ser Gln Lys Gly
        115                 120                 125             
Gly Leu Ser Val Ala Val Pro Gly Glu Ile Arg Gly Tyr Glu Leu Ala
    130                 135                 140                 
His Gln Arg His Gly Arg Leu Pro Trp Ala Arg Leu Phe Gln Pro Ser
145                 150                 155                 160 
Ile Gln Leu Ala Arg Gln Gly Phe Pro Val Gly Lys Gly Leu Ala Ala
                165                 170                 175     
Ala Leu Glu Asn Lys Arg Thr Val Ile Glu Gln Gln Pro Val Leu Cys
            180                 185                 190         
Glu Val Phe Cys Arg Asp Arg Lys Val Leu Arg Glu Gly Glu Arg Leu
        195                 200                 205             
Thr Leu Pro Gln Leu Ala Asp Thr Tyr Glu Thr Leu Ala Ile Glu Gly
    210                 215                 220                 
Ala Gln Ala Phe Tyr Asn Gly Ser Leu Thr Ala Gln Ile Val Lys Asp
225                 230                 235                 240 
Ile Gln Ala Ala Gly Gly Ile Val Thr Ala Glu Asp Leu Asn Asn Tyr
                245                 250                 255     
Arg Ala Glu Leu Ile Glu His Pro Leu Asn Ile Ser Leu Gly Asp Val
            260                 265                 270         
Val Leu Tyr Met Pro Ser Ala Pro Leu Ser Gly Pro Val Leu Ala Leu
        275                 280                 285             
Ile Leu Asn Ile Leu Lys Gly Tyr Asn Phe Ser Arg Glu Ser Val Glu
    290                 295                 300                 
Ser Pro Glu Gln Lys Gly Leu Thr Tyr His Arg Ile Val Glu Ala Phe
305                 310                 315                 320 
Arg Phe Ala Tyr Ala Lys Arg Thr Leu Leu Gly Asp Pro Lys Phe Val
                325                 330                 335     
Asp Val Thr Glu Val Val Arg Asn Met Thr Ser Glu Phe Phe Ala Ala
            340                 345                 350         
Gln Leu Arg Ala Gln Ile Ser Asp Asp Thr Thr His Pro Ile Ser Tyr
        355                 360                 365             
Tyr Lys Pro Glu Phe Tyr Thr Pro Asp Asp Gly Gly Thr Ala His Leu
    370                 375                 380                 
Ser Val Val Ala Glu Asp Gly Ser Ala Val Ser Ala Thr Ser Thr Ile
385                 390                 395                 400 
Asn Leu Tyr Phe Gly Ser Lys Val Arg Ser Pro Val Ser Gly Ile Leu
                405                 410                 415     
Phe Asn Asn Glu Met Asp Asp Phe Ser Ser Pro Ser Ile Thr Asn Glu
            420                 425                 430         
Phe Gly Val Pro Pro Ser Pro Ala Asn Phe Ile Gln Pro Gly Lys Gln
        435                 440                 445             
Pro Leu Ser Ser Met Cys Pro Thr Ile Met Val Gly Gln Asp Gly Gln
    450                 455                 460                 
Val Arg Met Val Val Gly Ala Ala Gly Gly Thr Gln Ile Thr Thr Ala
465                 470                 475                 480 
Thr Ala Leu Ala Ile Ile Tyr Asn Leu Trp Phe Gly Tyr Asp Val Lys
                485                 490                 495     
Arg Ala Val Glu Glu Pro Arg Leu His Asn Gln Leu Leu Pro Asn Val
            500                 505                 510         
Thr Thr Val Glu Arg Asn Ile Asp Gln Ala Val Thr Ala Ala Leu Glu
        515                 520                 525             
Thr Arg His His His Thr Gln Ile Ala Ser Thr Phe Ile Ala Val Val
    530                 535                 540                 
Gln Ala Ile Val Arg Thr Ala Gly Gly Trp Ala Ala Ala Ser Asp Ser
545                 550                 555                 560 
Arg Lys Gly Gly Glu Pro Ala Gly Tyr
                565                 


<210> 1682
<211> 455
<212> PRT
<213> Homo sapiens

<400> 1682
Met Ser Glu Ala Ser Ser Glu Asp Leu Val Pro Pro Leu Glu Ala Gly
 1               5                  10                  15      
Ala Ala Pro Tyr Arg Glu Glu Glu Glu Ala Ala Lys Lys Lys Lys Glu
            20                  25                  30          
Lys Lys Lys Lys Ser Lys Gly Leu Ala Asn Val Phe Cys Val Phe Thr
        35                  40                  45              
Lys Gly Lys Lys Lys Lys Gly Gln Pro Ser Ser Ala Glu Pro Glu Asp
    50                  55                  60                  
Ala Ala Gly Ser Arg Gln Gly Leu Asp Gly Pro Pro Pro Thr Val Glu
65                  70                  75                  80  
Glu Leu Lys Ala Ala Leu Glu Arg Gly Gln Leu Glu Ala Ala Arg Pro
                85                  90                  95      
Leu Leu Ala Leu Glu Arg Glu Leu Ala Ala Ala Ala Ala Ala Gly Gly
            100                 105                 110         
Val Ser Glu Glu Glu Leu Val Arg Arg Gln Ser Lys Val Glu Ala Leu
        115                 120                 125             
Tyr Glu Leu Leu Arg Asp Gln Val Leu Gly Val Leu Arg Arg Pro Leu
    130                 135                 140                 
Glu Ala Pro Pro Glu Arg Leu Arg Gln Ala Leu Ala Val Val Ala Glu
145                 150                 155                 160 
Gln Glu Arg Glu Asp Arg Gln Ala Ala Ala Ala Gly Pro Gly Thr Ser
                165                 170                 175     
Gly Leu Ala Ala Thr Arg Pro Arg Arg Trp Leu Gln Leu Trp Arg Arg
            180                 185                 190         
Gly Val Ala Glu Ala Ala Glu Glu Arg Met Gly Gln Arg Pro Ala Ala
        195                 200                 205             
Gly Ala Glu Val Pro Glu Ser Val Phe Leu His Leu Gly Arg Thr Met
    210                 215                 220                 
Lys Glu Asp Leu Glu Ala Val Val Glu Arg Leu Lys Pro Leu Phe Pro
225                 230                 235                 240 
Ala Glu Phe Gly Val Val Ala Ala Tyr Ala Glu Ser Tyr His Gln His
                245                 250                 255     
Phe Ala Ala His Leu Ala Ala Val Ala Gln Phe Glu Leu Cys Glu Arg
            260                 265                 270         
Asp Thr Tyr Met Leu Leu Leu Trp Val Gln Asn Leu Tyr Pro Asn Asp
        275                 280                 285             
Ile Ile Asn Ser Pro Lys Leu Val Gly Glu Leu Gln Gly Met Gly Leu
    290                 295                 300                 
Gly Ser Leu Leu Pro Pro Arg Gln Ile Arg Leu Leu Glu Ala Thr Phe
305                 310                 315                 320 
Leu Ser Ser Glu Ala Ala Asn Val Arg Glu Leu Met Asp Arg Ala Leu
                325                 330                 335     
Glu Leu Glu Ala Arg Arg Trp Ala Glu Asp Val Pro Pro Gln Arg Leu
            340                 345                 350         
Asp Gly His Cys His Ser Glu Leu Ala Ile Asp Ile Ile Gln Ile Thr
        355                 360                 365             
Ser Gln Ala Gln Ala Lys Ala Glu Ser Ile Thr Leu Asp Leu Gly Ser
    370                 375                 380                 
Gln Ile Lys Arg Val Leu Leu Val Glu Leu Pro Ala Phe Leu Arg Ser
385                 390                 395                 400 
Tyr Gln Arg Ala Phe Asn Glu Phe Leu Glu Arg Gly Lys Gln Leu Thr
                405                 410                 415     
Asn Tyr Arg Ala Asn Val Ile Ala Asn Ile Asn Asn Cys Leu Ser Phe
            420                 425                 430         
Arg Asp Val His Gly Ala Glu Leu Ala Gly Thr Pro Gly His Pro Glu
        435                 440                 445             
Pro Pro Ala Gly Pro Pro Gly
    450                 455 


<210> 1683
<211> 1051
<212> PRT
<213> Homo sapiens

<400> 1683
Met Asp Arg Asn Arg Glu Ala Glu Met Glu Leu Arg Arg Gly Pro Ser
 1               5                  10                  15      
Pro Thr Arg Ala Gly Arg Gly His Glu Val Asp Gly Asp Lys Ala Thr
            20                  25                  30          
Cys His Thr Cys Cys Ile Cys Gly Lys Ser Phe Pro Phe Gln Ser Ser
        35                  40                  45              
Leu Ser Gln His Met Arg Lys His Thr Gly Glu Lys Pro Tyr Lys Cys
    50                  55                  60                  
Pro Tyr Cys Asp His Arg Ala Ser Gln Lys Gly Asn Leu Lys Ile His
65                  70                  75                  80  
Ile Arg Ser His Arg Thr Gly Thr Leu Ile Gln Gly His Glu Pro Glu
                85                  90                  95      
Ala Gly Glu Ala Pro Leu Gly Glu Met Arg Ala Ser Glu Gly Leu Asp
            100                 105                 110         
Ala Cys Ala Ser Pro Thr Lys Ser Ala Ser Ala Cys Asn Arg Leu Leu
        115                 120                 125             
Asn Gly Ala Ser Gln Ala Asp Gly Ala Arg Val Leu Asn Gly Ala Ser
    130                 135                 140                 
Gln Ala Asp Ser Gly Arg Val Leu Leu Arg Ser Ser Lys Lys Gly Ala
145                 150                 155                 160 
Glu Gly Ser Ala Cys Ala Pro Gly Glu Ala Lys Ala Ala Val Gln Cys
                165                 170                 175     
Ser Phe Cys Lys Ser Gln Phe Glu Arg Lys Lys Asp Leu Glu Leu His
            180                 185                 190         
Val His Gln Ala His Lys Pro Phe Lys Cys Arg Leu Cys Ser Tyr Ala
        195                 200                 205             
Thr Leu Arg Glu Glu Ser Leu Leu Ser His Ile Glu Arg Asp His Ile
    210                 215                 220                 
Thr Ala Gln Gly Pro Gly Ser Gly Glu Ala Cys Val Glu Asn Gly Lys
225                 230                 235                 240 
Pro Glu Leu Ser Pro Gly Glu Phe Pro Cys Glu Val Cys Gly Gln Ala
                245                 250                 255     
Phe Ser Gln Thr Trp Phe Leu Lys Ala His Met Lys Lys His Arg Gly
            260                 265                 270         
Ser Phe Asp His Gly Cys His Ile Cys Gly Arg Arg Phe Lys Glu Pro
        275                 280                 285             
Trp Phe Leu Lys Asn His Met Lys Ala His Gly Pro Lys Thr Gly Ser
    290                 295                 300                 
Lys Asn Arg Pro Lys Ser Glu Leu Asp Pro Ile Ala Thr Ile Asn Asn
305                 310                 315                 320 
Val Val Gln Glu Glu Val Ile Val Ala Gly Leu Ser Leu Tyr Glu Val
                325                 330                 335     
Cys Ala Lys Cys Gly Asn Leu Phe Thr Asn Leu Asp Ser Leu Asn Ala
            340                 345                 350         
His Asn Ala Ile His Arg Arg Val Glu Ala Ser Arg Thr Arg Ala Pro
        355                 360                 365             
Ala Glu Glu Gly Ala Glu Gly Pro Ser Asp Thr Lys Gln Phe Phe Leu
    370                 375                 380                 
Gln Cys Leu Asn Leu Arg Pro Ser Ala Ala Gly Asp Ser Cys Pro Gly
385                 390                 395                 400 
Thr Gln Ala Gly Arg Arg Val Ala Glu Leu Asp Pro Val Asn Ser Tyr
                405                 410                 415     
Gln Ala Trp Gln Leu Ala Thr Arg Gly Lys Val Ala Glu Pro Ala Glu
            420                 425                 430         
Tyr Leu Lys Tyr Gly Ala Trp Asp Glu Ala Leu Ala Gly Asp Val Ala
        435                 440                 445             
Phe Asp Lys Asp Arg Arg Glu Tyr Val Leu Val Ser Gln Glu Lys Arg
    450                 455                 460                 
Lys Arg Glu Gln Asp Ala Pro Ala Ala Gln Gly Pro Pro Arg Lys Arg
465                 470                 475                 480 
Ala Ser Gly Pro Gly Asp Pro Ala Pro Ala Gly His Leu Asp Pro Arg
                485                 490                 495     
Ser Ala Ala Arg Pro Asn Arg Arg Ala Ala Ala Thr Thr Gly Gln Gly
            500                 505                 510         
Lys Ser Ser Glu Cys Phe Glu Cys Gly Lys Ile Phe Arg Thr Tyr His
        515                 520                 525             
Gln Met Val Leu His Ser Arg Val His Arg Arg Ala Arg Arg Glu Arg
    530                 535                 540                 
Asp Ser Asp Gly Asp Arg Ala Ala Arg Ala Arg Cys Gly Ser Leu Ser
545                 550                 555                 560 
Glu Gly Asp Ser Ala Ser Gln Pro Ser Ser Pro Gly Ser Ala Cys Ala
                565                 570                 575     
Ala Ala Asp Ser Pro Gly Ser Gly Leu Ala Asp Glu Ala Ala Glu Asp
            580                 585                 590         
Ser Gly Glu Glu Gly Ala Pro Glu Pro Ala Pro Gly Gly Gln Pro Arg
        595                 600                 605             
Arg Cys Cys Phe Ser Glu Glu Val Thr Ser Thr Glu Leu Ser Ser Gly
    610                 615                 620                 
Asp Gln Ser His Lys Met Gly Asp Asn Ala Ser Glu Arg Asp Thr Gly
625                 630                 635                 640 
Glu Ser Lys Ala Gly Ile Ala Ala Ser Val Ser Ile Leu Glu Asn Ser
                645                 650                 655     
Ser Arg Glu Thr Ser Arg Arg Gln Glu Gln His Arg Phe Ser Met Asp
            660                 665                 670         
Leu Lys Met Pro Ala Phe His Pro Lys Gln Glu Val Pro Val Pro Gly
        675                 680                 685             
Asp Gly Val Glu Phe Pro Ser Ser Thr Gly Ala Glu Gly Gln Thr Gly
    690                 695                 700                 
His Pro Ala Glu Lys Leu Ser Asp Leu His Asn Lys Glu His Ser Gly
705                 710                 715                 720 
Gly Gly Lys Arg Ala Leu Ala Pro Asp Leu Met Pro Leu Asp Leu Ser
                725                 730                 735     
Ala Arg Ser Thr Arg Asp Asp Pro Ser Asn Lys Glu Thr Ala Ser Ser
            740                 745                 750         
Leu Gln Ala Ala Leu Val Val His Pro Cys Pro Tyr Cys Ser His Lys
        755                 760                 765             
Thr Tyr Tyr Pro Glu Val Leu Trp Met His Lys Arg Ile Trp His Arg
    770                 775                 780                 
Val Ser Cys Asn Ser Val Ala Pro Pro Trp Ile Gln Pro Asn Gly Tyr
785                 790                 795                 800 
Lys Ser Ile Arg Ser Asn Leu Val Phe Leu Ser Arg Ser Gly Arg Thr
                805                 810                 815     
Gly Pro Pro Pro Ala Leu Gly Gly Lys Glu Cys Gln Pro Leu Leu Leu
            820                 825                 830         
Ala Arg Phe Thr Arg Thr Gln Val Pro Gly Gly Met Pro Gly Ser Lys
        835                 840                 845             
Ser Gly Ser Ser Pro Leu Gly Val Val Thr Lys Ala Ala Ser Met Pro
    850                 855                 860                 
Lys Asn Lys Glu Ser His Ser Gly Gly Pro Cys Ala Leu Trp Ala Pro
865                 870                 875                 880 
Gly Pro Asp Gly Tyr Arg Gln Thr Lys Pro Cys His Gly Gln Glu Pro
                885                 890                 895     
His Gly Ala Ala Thr Gln Gly Pro Leu Ala Lys Pro Arg Gln Glu Ala
            900                 905                 910         
Ser Ser Lys Pro Val Pro Ala Pro Gly Gly Gly Gly Phe Ser Arg Ser
        915                 920                 925             
Ala Thr Pro Thr Pro Thr Val Ile Ala Arg Ala Gly Ala Gln Pro Ser
    930                 935                 940                 
Ala Asn Ser Lys Pro Val Glu Lys Phe Gly Val Pro Pro Ala Gly Ala
945                 950                 955                 960 
Gly Phe Ala Pro Thr Asn Lys His Ser Ala Pro Asp Ser Leu Lys Ala
                965                 970                 975     
Lys Phe Ser Ala Gln Pro Gln Gly Pro Pro Pro Ala Lys Gly Glu Gly
            980                 985                 990         
Gly Ala Pro Pro Leu Pro Pro Arg Glu Pro Pro Ser Lys Ala Ala Gln
        995                 1000                1005            
Glu Leu Arg Thr Leu Ala Thr Cys Ala Ala Gly Ser Arg Gly Asp Ala
    1010                1015                1020                
Ala Leu Gln Ala Gln Pro Gly Val Ala Gly Ala Pro Pro Arg Pro Thr
1025                1030                1035                1040
Leu His Gln Thr Gly Ala Gly Gly Arg Gly Ala
                1045                1050    


<210> 1684
<211> 266
<212> PRT
<213> Homo sapiens

<400> 1684
Met Leu Leu Leu Thr Arg Ser Pro Thr Ala Trp His Arg Leu Ser Gln
 1               5                  10                  15      
Leu Lys Pro Arg Val Leu Pro Gly Thr Leu Gly Gly Gln Ala Leu His
            20                  25                  30          
Leu Arg Ser Trp Leu Leu Ser Arg Gln Gly Pro Ala Glu Thr Gly Gly
        35                  40                  45              
Gln Gly Gln Pro Gln Gly Pro Gly Leu Arg Thr Arg Leu Leu Ile Thr
    50                  55                  60                  
Gly Leu Phe Gly Ala Gly Leu Gly Gly Ala Trp Leu Ala Leu Arg Ala
65                  70                  75                  80  
Glu Lys Glu Arg Leu Gln Gln Gln Lys Arg Thr Glu Ala Leu Arg Gln
                85                  90                  95      
Ala Ala Val Gly Gln Gly Asp Phe His Leu Leu Asp His Arg Gly Arg
            100                 105                 110         
Ala Arg Cys Lys Ala Asp Phe Arg Gly Gln Trp Val Leu Met Tyr Phe
        115                 120                 125             
Gly Phe Thr His Cys Pro Asp Ile Cys Pro Asp Glu Leu Glu Lys Leu
    130                 135                 140                 
Val Gln Val Val Arg Gln Leu Glu Ala Glu Pro Gly Leu Pro Pro Val
145                 150                 155                 160 
Gln Pro Val Phe Ile Thr Val Asp Pro Glu Arg Asp Asp Val Glu Ala
                165                 170                 175     
Met Ala Arg Tyr Val Gln Asp Phe His Pro Arg Leu Leu Gly Leu Thr
            180                 185                 190         
Gly Ser Thr Lys Gln Val Ala Gln Ala Ser His Ser Tyr Arg Val Tyr
        195                 200                 205             
Tyr Asn Ala Gly Pro Lys Asp Glu Asp Gln Asp Tyr Ile Val Asp His
    210                 215                 220                 
Ser Ile Ala Ile Tyr Leu Leu Asn Pro Asp Gly Leu Phe Thr Asp Tyr
225                 230                 235                 240 
Tyr Gly Arg Ser Arg Ser Ala Glu Gln Ile Ser Asp Ser Val Arg Arg
                245                 250                 255     
His Met Ala Ala Phe Arg Ser Val Leu Ser
            260                 265     


<210> 1685
<211> 841
<212> PRT
<213> Homo sapiens

<400> 1685
Met Pro Leu Ala Ala Tyr Cys Tyr Leu Arg Val Val Gly Lys Gly Ser
 1               5                  10                  15      
Tyr Gly Glu Val Thr Leu Val Lys His Arg Arg Asp Gly Lys Gln Tyr
            20                  25                  30          
Val Ile Lys Lys Leu Asn Leu Arg Asn Ala Ser Ser Arg Glu Arg Arg
        35                  40                  45              
Ala Ala Glu Gln Glu Ala Gln Leu Leu Ser Gln Leu Lys His Pro Asn
    50                  55                  60                  
Ile Val Thr Tyr Lys Glu Ser Trp Glu Gly Gly Asp Gly Leu Leu Tyr
65                  70                  75                  80  
Ile Val Met Gly Phe Cys Glu Gly Gly Asp Leu Tyr Arg Lys Leu Lys
                85                  90                  95      
Glu Gln Lys Gly Gln Leu Leu Pro Glu Asn Gln Val Val Glu Trp Phe
            100                 105                 110         
Val Gln Ile Ala Met Ala Leu Gln Tyr Leu His Glu Lys His Ile Leu
        115                 120                 125             
His Arg Asp Leu Lys Thr Gln Asn Val Phe Leu Thr Arg Thr Asn Ile
    130                 135                 140                 
Ile Lys Val Gly Asp Leu Gly Ile Ala Arg Val Leu Glu Asn His Cys
145                 150                 155                 160 
Asp Met Ala Ser Thr Leu Ile Gly Thr Pro Tyr Tyr Met Ser Pro Glu
                165                 170                 175     
Leu Phe Ser Asn Lys Pro Tyr Asn Tyr Lys Ser Asp Val Trp Ala Leu
            180                 185                 190         
Gly Cys Cys Val Tyr Glu Met Ala Thr Leu Lys His Ala Phe Asn Ala
        195                 200                 205             
Lys Asp Met Asn Ser Leu Val Tyr Arg Ile Ile Glu Gly Lys Leu Pro
    210                 215                 220                 
Pro Met Pro Arg Asp Tyr Ser Pro Glu Leu Ala Glu Leu Ile Arg Thr
225                 230                 235                 240 
Met Leu Ser Lys Arg Pro Glu Glu Arg Pro Ser Val Arg Ser Ile Leu
                245                 250                 255     
Arg Gln Pro Tyr Ile Lys Arg Gln Ile Ser Phe Phe Leu Glu Ala Thr
            260                 265                 270         
Lys Ile Lys Thr Ser Lys Asn Asn Ile Lys Asn Gly Asp Ser Gln Ser
        275                 280                 285             
Lys Pro Phe Ala Thr Val Val Ser Gly Glu Ala Glu Ser Asn His Glu
    290                 295                 300                 
Val Ile His Pro Gln Pro Leu Ser Ser Glu Gly Ser Gln Thr Tyr Ile
305                 310                 315                 320 
Met Gly Glu Gly Lys Cys Leu Ser Gln Glu Lys Pro Arg Ala Ser Gly
                325                 330                 335     
Leu Leu Lys Ser Pro Ala Ser Leu Lys Ala His Thr Cys Lys Gln Asp
            340                 345                 350         
Leu Ser Asn Thr Thr Glu Leu Ala Thr Ile Ser Ser Val Asn Ile Asp
        355                 360                 365             
Ile Leu Pro Ala Lys Gly Arg Asp Ser Val Ser Asp Gly Phe Val Gln
    370                 375                 380                 
Glu Asn Gln Pro Arg Tyr Leu Asp Ala Ser Asn Glu Leu Gly Gly Ile
385                 390                 395                 400 
Cys Ser Ile Ser Gln Val Glu Glu Glu Met Leu Gln Asp Asn Thr Lys
                405                 410                 415     
Ser Ser Ala Gln Pro Glu Asn Leu Ile Pro Met Trp Ser Ser Asp Ile
            420                 425                 430         
Val Thr Gly Glu Lys Asn Glu Pro Val Lys Pro Leu Gln Pro Leu Ile
        435                 440                 445             
Lys Glu Gln Lys Pro Lys Asp Gln Ser Leu Ala Leu Ser Pro Lys Leu
    450                 455                 460                 
Glu Cys Ser Gly Thr Ile Leu Ala His Ser Asn Leu Arg Leu Leu Gly
465                 470                 475                 480 
Ser Ser Asp Ser Pro Ala Ser Ala Ser Arg Val Ala Gly Ile Thr Gly
                485                 490                 495     
Val Cys His His Ala Gln Asp Gln Val Ala Gly Glu Cys Ile Ile Glu
            500                 505                 510         
Lys Gln Gly Arg Ile His Pro Asp Leu Gln Pro His Asn Ser Gly Ser
        515                 520                 525             
Glu Pro Ser Leu Ser Arg Gln Arg Arg Gln Lys Arg Arg Glu Gln Thr
    530                 535                 540                 
Glu His Arg Gly Glu Lys Arg Gln Val Arg Arg Asp Leu Phe Ala Phe
545                 550                 555                 560 
Gln Glu Ser Pro Pro Arg Phe Leu Pro Ser His Pro Ile Val Gly Lys
                565                 570                 575     
Val Asp Val Thr Ser Thr Gln Lys Glu Ala Glu Asn Gln Arg Arg Val
            580                 585                 590         
Val Thr Gly Ser Val Ser Ser Ser Arg Ser Ser Glu Met Ser Ser Ser
        595                 600                 605             
Lys Asp Arg Pro Leu Ser Ala Arg Glu Arg Arg Arg Leu Lys Gln Ser
    610                 615                 620                 
Gln Glu Glu Met Ser Ser Ser Gly Pro Ser Val Arg Lys Ala Ser Leu
625                 630                 635                 640 
Ser Val Ala Gly Pro Gly Lys Pro Gln Glu Glu Asp Gln Pro Leu Pro
                645                 650                 655     
Ala Arg Arg Leu Ser Ser Asp Cys Ser Val Thr Gln Glu Arg Lys Gln
            660                 665                 670         
Ile His Cys Leu Ser Glu Asp Glu Leu Ser Ser Ser Thr Ser Ser Thr
        675                 680                 685             
Asp Lys Ser Asp Gly Asp Tyr Gly Glu Gly Lys Gly Gln Thr Asn Glu
    690                 695                 700                 
Ile Asn Ala Leu Val Gln Leu Met Thr Gln Thr Leu Lys Leu Asp Ser
705                 710                 715                 720 
Lys Glu Ser Cys Glu Asp Val Pro Val Ala Asn Pro Val Ser Glu Phe
                725                 730                 735     
Lys Leu His Arg Lys Tyr Arg Asp Thr Leu Ile Leu His Gly Lys Val
            740                 745                 750         
Ala Glu Glu Ala Glu Glu Ile His Phe Lys Glu Leu Pro Ser Ala Ile
        755                 760                 765             
Met Pro Gly Ser Glu Lys Ile Arg Arg Leu Val Glu Val Leu Arg Thr
    770                 775                 780                 
Asp Val Ile Arg Gly Leu Gly Val Gln Leu Leu Glu Gln Val Tyr Asp
785                 790                 795                 800 
Leu Leu Glu Glu Glu Asp Glu Phe Asp Arg Glu Val Arg Leu Arg Glu
                805                 810                 815     
His Met Gly Glu Lys Tyr Thr Thr Tyr Ser Val Lys Ala Arg Gln Leu
            820                 825                 830         
Lys Phe Phe Glu Glu Asn Met Asn Phe
        835                 840     


<210> 1686
<211> 968
<212> PRT
<213> Homo sapiens

<400> 1686
Met Asp Ser Thr Leu Thr Ala Ser Glu Ile Arg Gln Arg Phe Ile Asp
 1               5                  10                  15      
Phe Phe Lys Arg Asn Glu His Thr Tyr Val His Ser Ser Ala Thr Ile
            20                  25                  30          
Pro Leu Asp Asp Pro Thr Leu Leu Phe Ala Asn Ala Gly Met Asn Gln
        35                  40                  45              
Phe Lys Pro Ile Phe Leu Asn Thr Ile Asp Pro Ser His Pro Met Ala
    50                  55                  60                  
Lys Leu Ser Arg Ala Ala Asn Thr Gln Lys Cys Ile Arg Ala Gly Gly
65                  70                  75                  80  
Lys His Asn Asp Leu Asp Asp Val Gly Lys Asp Val Tyr His His Thr
                85                  90                  95      
Phe Phe Glu Met Leu Gly Ser Trp Ser Phe Gly Asp Tyr Phe Lys Glu
            100                 105                 110         
Leu Ala Cys Lys Met Ala Leu Glu Leu Leu Thr Gln Glu Phe Gly Ile
        115                 120                 125             
Pro Ile Glu Arg Leu Tyr Val Thr Tyr Phe Gly Gly Asp Glu Ala Ala
    130                 135                 140                 
Gly Leu Glu Ala Asp Leu Glu Cys Lys Gln Ile Trp Gln Asn Leu Gly
145                 150                 155                 160 
Leu Asp Asp Thr Lys Ile Leu Pro Gly Asn Met Lys Asp Asn Phe Trp
                165                 170                 175     
Glu Met Gly Asp Thr Gly Pro Cys Gly Pro Cys Ser Glu Ile His Tyr
            180                 185                 190         
Asp Arg Ile Gly Gly Arg Asp Ala Ala His Leu Val Asn Gln Asp Asp
        195                 200                 205             
Pro Asn Val Leu Glu Ile Trp Asn Leu Val Phe Ile Gln Tyr Asn Arg
    210                 215                 220                 
Glu Ala Asp Gly Ile Leu Lys Pro Leu Pro Lys Lys Ser Ile Asp Thr
225                 230                 235                 240 
Gly Met Gly Leu Glu Arg Leu Val Ser Val Leu Gln Asn Lys Met Ser
                245                 250                 255     
Asn Tyr Asp Thr Asp Leu Phe Val Pro Tyr Phe Glu Ala Ile Gln Lys
            260                 265                 270         
Gly Thr Gly Ala Arg Pro Tyr Thr Gly Lys Val Gly Ala Glu Asp Ala
        275                 280                 285             
Asp Gly Ile Asp Met Ala Tyr Arg Val Leu Ala Asp His Ala Arg Thr
    290                 295                 300                 
Ile Thr Val Ala Leu Ala Asp Gly Gly Arg Pro Asp Asn Thr Gly Arg
305                 310                 315                 320 
Gly Tyr Val Leu Arg Arg Ile Leu Arg Arg Ala Val Arg Tyr Ala His
                325                 330                 335     
Glu Lys Leu Asn Ala Ser Arg Gly Phe Phe Ala Thr Leu Val Asp Val
            340                 345                 350         
Val Val Gln Ser Leu Gly Asp Ala Phe Pro Glu Leu Lys Lys Asp Pro
        355                 360                 365             
Asp Met Val Lys Asp Ile Ile Asn Glu Glu Glu Val Gln Phe Leu Lys
    370                 375                 380                 
Thr Leu Ser Arg Gly Arg Arg Ile Leu Asp Arg Lys Ile Gln Ser Leu
385                 390                 395                 400 
Gly Asp Ser Lys Thr Ile Pro Gly Asp Thr Ala Trp Leu Leu Tyr Asp
                405                 410                 415     
Thr Tyr Gly Phe Pro Val Asp Leu Thr Gly Leu Ile Ala Glu Glu Lys
            420                 425                 430         
Gly Leu Val Val Asp Met Asp Gly Phe Glu Glu Glu Arg Lys Leu Ala
        435                 440                 445             
Gln Leu Lys Ser Gln Gly Lys Gly Ala Gly Gly Glu Asp Leu Ile Met
    450                 455                 460                 
Leu Asp Ile Tyr Ala Ile Glu Glu Leu Arg Ala Arg Gly Leu Glu Val
465                 470                 475                 480 
Thr Asp Asp Ser Pro Lys Tyr Asn Tyr His Leu Asp Ser Ser Gly Ser
                485                 490                 495     
Tyr Val Phe Glu Asn Thr Val Ala Thr Val Met Ala Leu Arg Arg Glu
            500                 505                 510         
Lys Met Phe Val Glu Glu Val Ser Thr Gly Gln Glu Cys Gly Val Val
        515                 520                 525             
Leu Asp Lys Thr Cys Phe Tyr Ala Glu Gln Gly Gly Gln Ile Tyr Asp
    530                 535                 540                 
Glu Gly Tyr Leu Val Lys Val Asp Asp Ser Ser Glu Asp Lys Thr Glu
545                 550                 555                 560 
Phe Thr Val Lys Asn Ala Gln Val Arg Gly Gly Tyr Val Leu His Ile
                565                 570                 575     
Gly Thr Ile Tyr Gly Asp Leu Lys Val Gly Asp Gln Val Trp Leu Phe
            580                 585                 590         
Ile Asp Glu Pro Arg Arg Arg Pro Ile Met Ser Asn His Thr Ala Thr
        595                 600                 605             
His Ile Leu Asn Phe Ala Leu Arg Ser Val Leu Gly Glu Ala Asp Gln
    610                 615                 620                 
Lys Gly Ser Leu Val Ala Pro Asp Arg Leu Arg Phe Asp Phe Thr Ala
625                 630                 635                 640 
Lys Gly Ala Met Ser Thr Gln Gln Ile Lys Lys Ala Glu Glu Ile Ala
                645                 650                 655     
Asn Glu Met Ile Glu Ala Ala Lys Ala Val Tyr Thr Gln Asp Cys Pro
            660                 665                 670         
Leu Ala Ala Ala Lys Ala Ile Gln Gly Leu Arg Ala Val Phe Asp Glu
        675                 680                 685             
Thr Tyr Pro Asp Pro Val Arg Val Val Ser Ile Gly Val Pro Val Ser
    690                 695                 700                 
Glu Leu Leu Asp Asp Pro Ser Gly Pro Ala Gly Ser Leu Thr Ser Val
705                 710                 715                 720 
Glu Phe Cys Gly Gly Thr His Leu Arg Asn Ser Ser His Ala Gly Ala
                725                 730                 735     
Phe Val Ile Val Thr Glu Glu Ala Ile Ala Lys Gly Ile Arg Arg Ile
            740                 745                 750         
Val Ala Val Thr Gly Ala Glu Ala Gln Lys Ala Leu Arg Lys Ala Glu
        755                 760                 765             
Ser Leu Lys Lys Cys Leu Ser Val Met Glu Ala Lys Val Lys Ala Gln
    770                 775                 780                 
Thr Ala Pro Asn Lys Asp Val Gln Arg Glu Ile Ala Asp Leu Gly Glu
785                 790                 795                 800 
Ala Leu Ala Thr Ala Val Ile Pro Gln Trp Gln Lys Asp Glu Leu Arg
                805                 810                 815     
Glu Thr Leu Lys Ser Leu Lys Lys Val Met Asp Asp Leu Asp Arg Ala
            820                 825                 830         
Ser Lys Ala Asp Val Gln Lys Arg Val Leu Glu Lys Thr Lys Gln Phe
        835                 840                 845             
Ile Asp Ser Asn Pro Asn Gln Pro Leu Val Ile Leu Glu Met Glu Ser
    850                 855                 860                 
Gly Ala Ser Ala Lys Ala Leu Asn Glu Ala Leu Lys Leu Phe Lys Met
865                 870                 875                 880 
His Ser Pro Gln Thr Ser Ala Met Leu Phe Thr Val Asp Asn Glu Ala
                885                 890                 895     
Gly Lys Ile Thr Cys Leu Cys Gln Val Pro Gln Asn Ala Ala Asn Arg
            900                 905                 910         
Gly Leu Lys Ala Ser Glu Trp Val Gln Gln Val Ser Gly Leu Met Asp
        915                 920                 925             
Gly Lys Gly Gly Gly Lys Asp Val Ser Ala Gln Ala Thr Gly Lys Asn
    930                 935                 940                 
Val Gly Cys Leu Gln Glu Ala Leu Gln Leu Ala Thr Ser Phe Ala Gln
945                 950                 955                 960 
Leu Arg Leu Gly Asp Val Lys Asn
                965             


<210> 1687
<211> 2725
<212> PRT
<213> Homo sapiens

<400> 1687
Met Glu Gln Thr Asp Cys Lys Pro Tyr Gln Pro Leu Pro Lys Val Lys
 1               5                  10                  15      
His Glu Met Asp Leu Ala Tyr Thr Ser Ser Ser Asp Glu Ser Glu Asp
            20                  25                  30          
Gly Arg Lys Pro Arg Gln Ser Tyr Asn Ser Arg Glu Thr Leu His Glu
        35                  40                  45              
Tyr Asn Gln Glu Leu Arg Met Asn Tyr Asn Ser Gln Ser Arg Lys Arg
    50                  55                  60                  
Lys Glu Val Glu Lys Ser Thr Gln Glu Met Glu Phe Cys Glu Thr Ser
65                  70                  75                  80  
His Thr Leu Cys Ser Gly Tyr Gln Thr Asp Met His Ser Val Ser Arg
                85                  90                  95      
His Gly Tyr Gln Leu Glu Met Gly Ser Asp Val Asp Thr Glu Thr Glu
            100                 105                 110         
Gly Ala Ala Ser Pro Asp His Ala Leu Arg Met Trp Ile Arg Gly Met
        115                 120                 125             
Lys Ser Glu His Ser Ser Cys Leu Ser Ser Arg Ala Asn Ser Ala Leu
    130                 135                 140                 
Ser Leu Thr Asp Thr Asp His Glu Arg Lys Ser Asp Gly Glu Asn Gly
145                 150                 155                 160 
Phe Lys Phe Ser Pro Val Cys Cys Asp Met Glu Ala Gln Ala Gly Ser
                165                 170                 175     
Thr Gln Asp Val Gln Ser Ser Pro His Asn Gln Phe Thr Phe Arg Pro
            180                 185                 190         
Leu Pro Pro Pro Pro Pro Pro Pro His Ala Cys Thr Cys Ala Arg Lys
        195                 200                 205             
Pro Pro Pro Ala Ala Asp Ser Leu Gln Arg Arg Ser Met Thr Thr Arg
    210                 215                 220                 
Ser Gln Pro Ser Pro Ala Ala Pro Ala Pro Pro Thr Ser Thr Gln Asp
225                 230                 235                 240 
Ser Val His Leu His Asn Ser Trp Val Leu Asn Ser Asn Ile Pro Leu
                245                 250                 255     
Glu Thr Arg His Phe Leu Phe Lys His Gly Ser Gly Ser Ser Ala Ile
            260                 265                 270         
Phe Ser Ala Ala Ser Gln Asn Tyr Pro Leu Thr Ser Asn Thr Val Tyr
        275                 280                 285             
Ser Pro Pro Pro Arg Pro Leu Pro Arg Ser Thr Phe Ser Arg Pro Ala
    290                 295                 300                 
Phe Thr Phe Asn Lys Pro Tyr Arg Cys Cys Asn Trp Lys Cys Thr Ala
305                 310                 315                 320 
Leu Ser Ala Thr Ala Ile Thr Val Thr Leu Ala Leu Leu Leu Ala Tyr
                325                 330                 335     
Val Ile Ala Val His Leu Phe Gly Leu Thr Trp Gln Leu Gln Pro Val
            340                 345                 350         
Glu Gly Glu Leu Tyr Ala Asn Gly Val Ser Lys Gly Asn Arg Gly Thr
        355                 360                 365             
Glu Ser Met Asp Thr Thr Tyr Ser Pro Ile Gly Gly Lys Val Ser Asp
    370                 375                 380                 
Lys Ser Glu Lys Lys Val Phe Gln Lys Gly Arg Ala Ile Asp Thr Gly
385                 390                 395                 400 
Glu Val Asp Ile Gly Ala Gln Val Met Gln Thr Ile Pro Pro Gly Leu
                405                 410                 415     
Phe Trp Arg Phe Gln Ile Thr Ile His His Pro Ile Tyr Leu Lys Phe
            420                 425                 430         
Asn Ile Ser Leu Ala Lys Asp Ser Leu Leu Gly Ile Tyr Gly Arg Arg
        435                 440                 445             
Asn Ile Pro Pro Thr His Thr Gln Phe Asp Phe Val Lys Leu Met Asp
    450                 455                 460                 
Gly Lys Gln Leu Val Lys Gln Asp Ser Lys Gly Ser Asp Asp Thr Gln
465                 470                 475                 480 
His Ser Pro Arg Asn Leu Ile Leu Thr Ser Leu Gln Glu Thr Gly Phe
                485                 490                 495     
Ile Glu Tyr Met Asp Gln Gly Pro Trp Tyr Leu Ala Phe Tyr Asn Asp
            500                 505                 510         
Gly Lys Lys Met Glu Gln Val Phe Val Leu Thr Thr Ala Ile Glu Ile
        515                 520                 525             
Met Asp Asp Cys Ser Thr Asn Cys Asn Gly Asn Gly Glu Cys Ile Ser
    530                 535                 540                 
Gly His Cys His Cys Phe Pro Gly Phe Leu Gly Pro Asp Cys Ala Arg
545                 550                 555                 560 
Asp Ser Cys Pro Val Leu Cys Gly Gly Asn Gly Glu Tyr Glu Lys Gly
                565                 570                 575     
His Cys Val Cys Arg His Gly Trp Lys Gly Pro Glu Cys Asp Val Pro
            580                 585                 590         
Glu Glu Gln Cys Ile Asp Pro Thr Cys Phe Gly His Gly Thr Cys Ile
        595                 600                 605             
Met Gly Val Cys Ile Cys Val Pro Gly Tyr Lys Gly Glu Ile Cys Glu
    610                 615                 620                 
Glu Glu Asp Cys Leu Asp Pro Met Cys Ser Asn His Gly Ile Cys Val
625                 630                 635                 640 
Lys Gly Glu Cys His Cys Ser Thr Gly Trp Gly Gly Val Asn Cys Glu
                645                 650                 655     
Thr Pro Leu Pro Val Cys Gln Glu Gln Cys Ser Gly His Gly Thr Phe
            660                 665                 670         
Leu Leu Asp Ala Gly Val Cys Ser Cys Asp Pro Lys Trp Thr Gly Ser
        675                 680                 685             
Asp Cys Ser Thr Glu Leu Cys Thr Met Glu Cys Gly Ser His Gly Val
    690                 695                 700                 
Cys Ser Arg Gly Ile Cys Gln Cys Glu Glu Gly Trp Val Gly Pro Thr
705                 710                 715                 720 
Cys Glu Glu Arg Ser Cys His Ser His Cys Thr Glu His Gly Gln Cys
                725                 730                 735     
Lys Asp Gly Lys Cys Glu Cys Ser Pro Gly Trp Glu Gly Asp His Cys
            740                 745                 750         
Thr Ile Ala His Tyr Leu Asp Ala Val Arg Asp Gly Cys Pro Gly Leu
        755                 760                 765             
Cys Phe Gly Asn Gly Arg Cys Thr Leu Asp Gln Asn Gly Trp His Cys
    770                 775                 780                 
Val Cys Gln Val Gly Trp Ser Gly Thr Gly Cys Asn Val Val Met Glu
785                 790                 795                 800 
Met Leu Cys Gly Asp Asn Leu Asp Asn Asp Gly Asp Gly Leu Thr Asp
                805                 810                 815     
Cys Val Asp Pro Asp Cys Cys Gln Gln Ser Asn Cys Tyr Ile Ser Pro
            820                 825                 830         
Leu Cys Gln Gly Ser Pro Asp Pro Leu Asp Leu Ile Gln Gln Ser Gln
        835                 840                 845             
Thr Leu Phe Ser Gln His Thr Ser Arg Leu Phe Tyr Asp Arg Ile Lys
    850                 855                 860                 
Phe Leu Ile Gly Lys Asp Ser Thr His Val Ile Pro Pro Glu Val Ser
865                 870                 875                 880 
Phe Asp Ser Arg Arg Ala Cys Val Ile Arg Gly Gln Val Val Ala Ile
                885                 890                 895     
Asp Gly Thr Pro Leu Val Gly Val Asn Val Ser Phe Leu His His Ser
            900                 905                 910         
Asp Tyr Gly Phe Thr Ile Ser Arg Gln Asp Gly Ser Phe Asp Leu Val
        915                 920                 925             
Ala Ile Gly Gly Ile Ser Val Ile Leu Ile Phe Asp Arg Ser Pro Phe
    930                 935                 940                 
Leu Pro Glu Lys Arg Thr Leu Trp Leu Pro Trp Asn Gln Phe Ile Val
945                 950                 955                 960 
Val Glu Lys Val Thr Met Gln Arg Val Val Ser Asp Pro Pro Ser Cys
                965                 970                 975     
Asp Ile Ser Asn Phe Ile Ser Pro Asn Pro Ile Val Leu Pro Ser Pro
            980                 985                 990         
Leu Thr Ser Phe Gly Gly Ser Cys Pro Glu Arg Gly Thr Ile Val Pro
        995                 1000                1005            
Glu Leu Gln Val Val Gln Glu Glu Ile Pro Ile Pro Ser Ser Phe Val
    1010                1015                1020                
Arg Leu Ser Tyr Leu Ser Ser Arg Thr Pro Gly Tyr Lys Thr Leu Leu
1025                1030                1035                1040
Arg Ile Leu Leu Thr His Ser Thr Ile Pro Val Gly Met Ile Lys Val
                1045                1050                1055    
His Leu Thr Val Ala Val Glu Gly Arg Leu Thr Gln Lys Trp Phe Pro
            1060                1065                1070        
Ala Ala Ile Asn Leu Val Tyr Thr Phe Ala Trp Asn Lys Thr Asp Ile
        1075                1080                1085            
Tyr Gly Gln Lys Val Trp Gly Leu Ala Glu Ala Leu Val Ser Val Gly
    1090                1095                1100                
Tyr Glu Tyr Glu Thr Cys Pro Asp Phe Ile Leu Trp Glu Gln Arg Thr
1105                1110                1115                1120
Val Val Leu Gln Gly Phe Glu Met Asp Ala Ser Asn Leu Gly Gly Trp
                1125                1130                1135    
Ser Leu Asn Lys His His Ile Leu Asn Pro Gln Ser Gly Ile Ile His
            1140                1145                1150        
Lys Gly Asn Gly Glu Asn Met Phe Ile Ser Gln Gln Pro Pro Val Ile
        1155                1160                1165            
Ser Thr Ile Met Gly Asn Gly His Gln Arg Ser Val Ala Cys Thr Asn
    1170                1175                1180                
Cys Asn Gly Pro Ala His Asn Asn Lys Leu Phe Ala Pro Val Ala Leu
1185                1190                1195                1200
Ala Ser Gly Pro Asp Gly Ser Val Tyr Val Gly Asp Phe Asn Phe Val
                1205                1210                1215    
Arg Arg Ile Phe Pro Ser Gly Asn Ser Val Ser Ile Leu Glu Leu Ser
            1220                1225                1230        
Thr Ser Pro Ala His Lys Tyr Tyr Leu Ala Met Asp Pro Val Ser Glu
        1235                1240                1245            
Ser Leu Tyr Leu Ser Asp Thr Asn Thr Arg Lys Val Tyr Lys Leu Lys
    1250                1255                1260                
Ser Leu Val Glu Thr Lys Asp Leu Ser Lys Asn Phe Glu Val Val Ala
1265                1270                1275                1280
Gly Thr Gly Asp Gln Cys Leu Pro Phe Asp Gln Ser His Cys Gly Asp
                1285                1290                1295    
Gly Gly Arg Ala Ser Glu Ala Ser Leu Asn Ser Pro Arg Gly Ile Thr
            1300                1305                1310        
Val Asp Arg His Gly Phe Ile Tyr Phe Val Asp Gly Thr Met Ile Arg
        1315                1320                1325            
Lys Ile Asp Glu Asn Ala Val Ile Thr Thr Val Ile Gly Ser Asn Gly
    1330                1335                1340                
Leu Thr Ser Thr Gln Pro Leu Ser Cys Asp Ser Gly Met Asp Ile Thr
1345                1350                1355                1360
Gln Val Arg Leu Glu Trp Pro Thr Asp Leu Ala Val Asn Pro Met Asp
                1365                1370                1375    
Asn Ser Leu Tyr Val Leu Asp Asn Asn Ile Val Leu Gln Ile Ser Glu
            1380                1385                1390        
Asn Arg Arg Val Arg Ile Ile Ala Gly Arg Pro Ile His Cys Gln Val
        1395                1400                1405            
Pro Gly Ile Asp His Phe Leu Val Ser Lys Val Ala Ile His Ser Thr
    1410                1415                1420                
Leu Glu Ser Ala Arg Ala Ile Ser Val Ser His Ser Gly Leu Leu Phe
1425                1430                1435                1440
Ile Ala Glu Thr Asp Glu Arg Lys Val Asn Arg Ile Gln Gln Val Thr
                1445                1450                1455    
Thr Asn Gly Glu Ile Tyr Ile Ile Ala Gly Ala Pro Thr Asp Cys Asp
            1460                1465                1470        
Cys Lys Ile Asp Pro Asn Cys Asp Cys Phe Ser Gly Asp Gly Gly Tyr
        1475                1480                1485            
Ala Lys Asp Ala Lys Met Lys Ala Pro Ser Ser Leu Ala Val Ser Pro
    1490                1495                1500                
Asp Gly Thr Leu Tyr Val Ala Asp Leu Gly Asn Val Arg Ile Arg Thr
1505                1510                1515                1520
Ile Ser Arg Asn Gln Ala His Leu Asn Asp Met Asn Ile Tyr Glu Ile
                1525                1530                1535    
Ala Ser Pro Ala Asp Gln Glu Leu Tyr Gln Phe Thr Val Asn Gly Thr
            1540                1545                1550        
His Leu His Thr Leu Asn Leu Ile Thr Arg Asp Tyr Val Tyr Asn Phe
        1555                1560                1565            
Thr Tyr Asn Ser Glu Gly Asp Leu Gly Ala Ile Thr Ser Ser Asn Gly
    1570                1575                1580                
Asn Ser Val His Ile Arg Arg Asp Ala Gly Gly Met Pro Leu Trp Leu
1585                1590                1595                1600
Val Val Pro Gly Gly Gln Val Tyr Trp Leu Thr Ile Ser Ser Asn Gly
                1605                1610                1615    
Val Leu Lys Arg Val Ser Ala Gln Gly Tyr Asn Leu Ala Leu Met Thr
            1620                1625                1630        
Tyr Pro Gly Asn Thr Gly Leu Leu Ala Thr Lys Ser Asn Glu Asn Gly
        1635                1640                1645            
Trp Thr Thr Val Tyr Glu Tyr Asp Pro Glu Gly His Leu Thr Asn Ala
    1650                1655                1660                
Thr Phe Pro Thr Gly Glu Val Ser Ser Phe His Ser Asp Leu Glu Lys
1665                1670                1675                1680
Leu Thr Lys Val Glu Leu Asp Thr Ser Asn Arg Glu Asn Val Leu Met
                1685                1690                1695    
Ser Thr Asn Leu Thr Ala Thr Ser Thr Ile Tyr Ile Leu Lys Gln Glu
            1700                1705                1710        
Asn Thr Gln Ser Thr Tyr Arg Val Asn Pro Asp Gly Ser Leu Arg Val
        1715                1720                1725            
Thr Phe Ala Ser Gly Met Glu Ile Gly Leu Ser Ser Glu Pro His Ile
    1730                1735                1740                
Leu Ala Gly Ala Val Asn Pro Thr Leu Gly Lys Cys Asn Ile Ser Leu
1745                1750                1755                1760
Pro Gly Glu His Asn Ala Asn Leu Ile Glu Trp Arg Gln Arg Lys Glu
                1765                1770                1775    
Gln Asn Lys Gly Asn Val Ser Ala Phe Glu Arg Arg Leu Arg Ala His
            1780                1785                1790        
Asn Arg Asn Leu Leu Ser Ile Asp Phe Asp His Ile Thr Arg Thr Gly
        1795                1800                1805            
Lys Ile Tyr Asp Asp His Arg Lys Phe Thr Leu Arg Ile Leu Tyr Asp
    1810                1815                1820                
Gln Thr Gly Arg Pro Ile Leu Trp Ser Pro Val Ser Arg Tyr Asn Glu
1825                1830                1835                1840
Val Asn Ile Thr Tyr Ser Pro Ser Gly Leu Val Thr Phe Ile Gln Arg
                1845                1850                1855    
Gly Thr Trp Asn Glu Lys Met Glu Tyr Asp Gln Ser Gly Lys Ile Ile
            1860                1865                1870        
Ser Arg Thr Trp Ala Asp Gly Lys Ile Trp Ser Tyr Thr Tyr Leu Glu
        1875                1880                1885            
Lys Ser Val Met Leu Leu Leu His Ser Gln Arg Arg Tyr Ile Phe Glu
    1890                1895                1900                
Tyr Asp Gln Pro Asp Cys Leu Leu Ser Val Thr Met Pro Ser Met Val
1905                1910                1915                1920
Arg His Ser Leu Gln Thr Met Leu Ser Val Gly Tyr Tyr Arg Asn Ile
                1925                1930                1935    
Tyr Thr Pro Pro Asp Ser Ser Thr Ser Phe Ile Gln Asp Tyr Ser Arg
            1940                1945                1950        
Asp Gly Arg Leu Leu Gln Thr Leu His Leu Gly Thr Gly Arg Arg Val
        1955                1960                1965            
Leu Tyr Lys Tyr Thr Lys Gln Ala Arg Leu Ser Glu Val Leu Tyr Asp
    1970                1975                1980                
Thr Thr Gln Val Thr Leu Thr Tyr Glu Glu Ser Ser Gly Val Ile Lys
1985                1990                1995                2000
Thr Ile His Leu Met His Asp Gly Phe Ile Cys Thr Ile Arg Tyr Arg
                2005                2010                2015    
Gln Thr Gly Pro Leu Ile Gly Arg Gln Ile Phe Arg Phe Ser Glu Glu
            2020                2025                2030        
Gly Leu Val Asn Ala Arg Phe Asp Tyr Ser Tyr Asn Asn Phe Arg Val
        2035                2040                2045            
Thr Ser Met Gln Ala Val Ile Asn Glu Thr Pro Leu Pro Ile Asp Leu
    2050                2055                2060                
Tyr Arg Tyr Val Asp Val Ser Gly Arg Thr Glu Gln Phe Gly Lys Phe
2065                2070                2075                2080
Ser Val Ile Asn Tyr Asp Leu Asn Gln Val Ile Thr Thr Thr Val Met
                2085                2090                2095    
Lys His Thr Lys Ile Phe Ser Ala Asn Gly Gln Val Ile Glu Val Gln
            2100                2105                2110        
Tyr Glu Ile Leu Lys Ala Ile Ala Tyr Trp Met Thr Ile Gln Tyr Asp
        2115                2120                2125            
Asn Val Gly Arg Met Val Ile Cys Asp Ile Arg Val Gly Val Asp Ala
    2130                2135                2140                
Asn Ile Thr Arg Tyr Phe Tyr Glu Tyr Asp Ala Asp Gly Gln Leu Gln
2145                2150                2155                2160
Thr Val Ser Val Asn Asp Lys Thr Gln Trp Arg Tyr Ser Tyr Asp Leu
                2165                2170                2175    
Asn Gly Asn Ile Asn Leu Leu Ser His Gly Lys Ser Ala Arg Leu Thr
            2180                2185                2190        
Pro Leu Arg Tyr Asp Leu Arg Asp Arg Ile Thr Arg Leu Gly Glu Ile
        2195                2200                2205            
Gln Tyr Lys Met Asp Glu Asp Gly Phe Leu Arg Gln Arg Gly Asn Asp
    2210                2215                2220                
Ile Phe Glu Tyr Asn Ser Asn Gly Leu Leu Gln Lys Ala Tyr Asn Lys
2225                2230                2235                2240
Ala Ser Gly Trp Thr Val Gln Tyr Tyr Tyr Asp Gly Leu Gly Arg Arg
                2245                2250                2255    
Val Ala Ser Lys Ser Ser Leu Gly Gln His Leu Gln Phe Phe Tyr Ala
            2260                2265                2270        
Asp Leu Thr Asn Pro Ile Arg Val Thr His Leu Tyr Asn His Thr Ser
        2275                2280                2285            
Ser Glu Ile Thr Ser Leu Tyr Tyr Asp Leu Gln Gly His Leu Ile Ala
    2290                2295                2300                
Met Glu Leu Ser Ser Gly Glu Glu Tyr Tyr Val Ala Cys Asp Asn Thr
2305                2310                2315                2320
Gly Thr Pro Leu Ala Val Phe Ser Ser Arg Gly Gln Val Ile Lys Glu
                2325                2330                2335    
Ile Leu Tyr Thr Pro Tyr Gly Asp Ile Tyr His Asp Thr Tyr Pro Asp
            2340                2345                2350        
Phe Gln Val Ile Ile Gly Phe His Gly Gly Leu Tyr Asp Phe Leu Thr
        2355                2360                2365            
Lys Leu Val His Leu Gly Gln Arg Asp Tyr Asp Val Val Ala Gly Arg
    2370                2375                2380                
Trp Thr Thr Pro Asn His His Ile Trp Lys Gln Leu Asn Leu Leu Pro
2385                2390                2395                2400
Lys Pro Phe Asn Leu Tyr Ser Phe Glu Asn Asn Tyr Pro Val Gly Lys
                2405                2410                2415    
Ile Gln Asp Val Ala Lys Tyr Thr Thr Asp Ile Arg Ser Trp Leu Glu
            2420                2425                2430        
Leu Phe Gly Phe Gln Leu His Asn Val Leu Pro Gly Phe Pro Lys Pro
        2435                2440                2445            
Glu Leu Glu Asn Leu Glu Leu Thr Tyr Glu Leu Leu Arg Leu Gln Thr
    2450                2455                2460                
Lys Thr Gln Glu Trp Asp Pro Gly Lys Thr Ile Leu Gly Ile Gln Cys
2465                2470                2475                2480
Glu Leu Gln Lys Gln Leu Arg Asn Phe Ile Ser Leu Asp Gln Leu Pro
                2485                2490                2495    
Met Thr Pro Arg Tyr Asn Asp Gly Arg Cys Leu Glu Gly Gly Lys Gln
            2500                2505                2510        
Pro Arg Phe Ala Ala Val Pro Ser Val Phe Gly Lys Gly Ile Lys Phe
        2515                2520                2525            
Ala Ile Lys Asp Gly Ile Val Thr Ala Asp Ile Ile Gly Val Ala Asn
    2530                2535                2540                
Glu Asp Ser Arg Arg Leu Ala Ala Ile Leu Asn Asn Ala His Tyr Leu
2545                2550                2555                2560
Glu Asn Leu His Phe Thr Ile Glu Gly Arg Asp Thr His Tyr Phe Ile
                2565                2570                2575    
Lys Leu Gly Ser Leu Glu Glu Asp Leu Val Leu Ile Gly Asn Thr Gly
            2580                2585                2590        
Gly Arg Arg Ile Leu Glu Asn Gly Val Asn Val Thr Val Ser Gln Met
        2595                2600                2605            
Thr Ser Val Leu Asn Gly Arg Thr Arg Arg Phe Ala Asp Ile Gln Leu
    2610                2615                2620                
Gln His Gly Ala Leu Cys Phe Asn Ile Arg Tyr Gly Thr Thr Val Glu
2625                2630                2635                2640
Glu Glu Lys Asn His Val Leu Glu Ile Ala Arg Gln Arg Ala Val Ala
                2645                2650                2655    
Gln Ala Trp Thr Lys Glu Gln Arg Arg Leu Gln Glu Gly Glu Glu Gly
            2660                2665                2670        
Ile Arg Ala Trp Thr Glu Gly Glu Lys Gln Gln Leu Leu Ser Thr Gly
        2675                2680                2685            
Arg Val Gln Gly Tyr Asp Gly Tyr Phe Val Leu Ser Val Glu Gln Tyr
    2690                2695                2700                
Leu Glu Leu Ser Asp Ser Ala Asn Asn Ile His Phe Met Arg Gln Ser
2705                2710                2715                2720
Glu Ile Gly Arg Arg
                2725


<210> 1688
<211> 1001
<212> PRT
<213> Homo sapiens

<400> 1688
Met Ala Thr Arg Thr Arg Gln Glu Tyr Leu Lys Asp Leu Ala Glu Lys
 1               5                  10                  15      
Asn Val Thr Asn Thr Pro Ile Asp Pro Ser Gly Lys Phe Pro Phe Ile
            20                  25                  30          
Ser Leu Ala Ser Lys Lys Lys Glu Lys Ser Lys Pro Tyr Pro Gly Ala
        35                  40                  45              
Glu Leu Ser Ser Met Gly Ala Ile Val Trp Ala Val Arg Ala Glu Asp
    50                  55                  60                  
Tyr Asn Lys Ala Met Glu Leu Asp Cys Leu Leu Gly Ile Ser Asn Glu
65                  70                  75                  80  
Phe Ile Val Leu Ile Glu Gln Glu Thr Lys Ser Val Val Phe Asn Cys
                85                  90                  95      
Ser Cys Arg Asp Val Ile Gly Trp Thr Ser Thr Asp Thr Ser Leu Lys
            100                 105                 110         
Ile Phe Tyr Glu Arg Gly Glu Cys Val Ser Val Gly Ser Phe Ile Asn
        115                 120                 125             
Ile Glu Glu Ile Lys Glu Ile Val Lys Arg Leu Gln Phe Val Ser Lys
    130                 135                 140                 
Gly Cys Glu Ser Val Glu Met Thr Leu Arg Arg Asn Gly Leu Gly Gln
145                 150                 155                 160 
Leu Gly Phe His Val Asn Tyr Glu Gly Ile Val Ala Asp Val Glu Pro
                165                 170                 175     
Tyr Gly Tyr Ala Trp Gln Ala Gly Leu Arg Gln Gly Ser Arg Leu Val
            180                 185                 190         
Glu Ile Cys Lys Val Ala Val Ala Thr Leu Ser His Glu Gln Met Ile
        195                 200                 205             
Asp Leu Leu Arg Thr Ser Val Thr Val Lys Val Val Ile Ile Pro Pro
    210                 215                 220                 
His Asp Asp Cys Thr Pro Arg Arg Ser Cys Ser Glu Thr Tyr Arg Met
225                 230                 235                 240 
Pro Val Met Glu Tyr Lys Met Asn Glu Gly Val Ser Tyr Glu Phe Lys
                245                 250                 255     
Phe Pro Phe Arg Asn Asn Asn Lys Trp Gln Arg Asn Ala Ser Lys Gly
            260                 265                 270         
Pro His Ser Pro Gln Val Pro Ser Gln Val Gln Ser Pro Met Thr Ser
        275                 280                 285             
Arg Leu Asn Ala Gly Lys Gly Asp Gly Lys Met Pro Pro Pro Glu Arg
    290                 295                 300                 
Ala Ala Asn Ile Pro Arg Ser Ile Ser Ser Asp Gly Arg Pro Leu Glu
305                 310                 315                 320 
Arg Arg Leu Ser Pro Gly Ser Asp Ile Tyr Val Thr Val Ser Ser Met
                325                 330                 335     
Ala Leu Ala Arg Ser Gln Cys Arg Asn Ser Pro Ser Asn Leu Ser Ser
            340                 345                 350         
Ser Ser Asp Thr Gly Ser Val Gly Gly Thr Tyr Arg Gln Lys Ser Met
        355                 360                 365             
Pro Glu Gly Phe Gly Val Ser Arg Arg Ser Pro Ala Ser Ile Asp Arg
    370                 375                 380                 
Gln Asn Thr Gln Ser Asp Ile Gly Gly Ser Gly Lys Ser Thr Pro Ser
385                 390                 395                 400 
Trp Gln Arg Ser Glu Asp Ser Ile Ala Asp Gln Met Ala Tyr Ser Tyr
                405                 410                 415     
Arg Gly Pro Gln Asp Phe Asn Ser Phe Val Leu Glu Gln His Glu Tyr
            420                 425                 430         
Thr Glu Pro Thr Cys His Leu Pro Ala Val Ser Lys Val Leu Pro Ala
        435                 440                 445             
Phe Arg Glu Ser Pro Ser Gly Arg Leu Met Arg Gln Asp Pro Val Val
    450                 455                 460                 
His Leu Ser Pro Asn Lys Gln Gly His Ser Asp Ser His Tyr Ser Ser
465                 470                 475                 480 
His Ser Ser Ser Asn Thr Leu Ser Ser Asn Ala Ser Ser Ala His Ser
                485                 490                 495     
Asp Glu Lys Trp Tyr Asp Gly Asp Arg Thr Glu Ser Glu Leu Asn Ser
            500                 505                 510         
Tyr Asn Tyr Leu Gln Gly Thr Ser Ala Asp Ser Gly Ile Asp Thr Thr
        515                 520                 525             
Ser Tyr Gly Pro Ser His Gly Ser Thr Ala Ser Leu Gly Ala Ala Thr
    530                 535                 540                 
Ser Ser Pro Arg Ser Gly Pro Gly Lys Glu Lys Val Ala Pro Leu Trp
545                 550                 555                 560 
His Ser Ser Ser Glu Val Ile Ser Met Ala Asp Arg Thr Leu Glu Thr
                565                 570                 575     
Glu Ser His Gly Leu Asp Arg Lys Thr Glu Ser Ser Leu Ser Leu Asp
            580                 585                 590         
Ile His Ser Lys Ser Gln Ala Gly Ser Thr Pro Leu Thr Arg Glu Asn
        595                 600                 605             
Ser Thr Phe Ser Ile Asn Asp Ala Ala Ser His Thr Ser Thr Met Ser
    610                 615                 620                 
Ser Arg His Ser Ala Ser Pro Val Val Phe Thr Ser Ala Arg Ser Ser
625                 630                 635                 640 
Pro Lys Glu Glu Leu His Pro Ala Ala Pro Ser Gln Leu Ala Pro Ser
                645                 650                 655     
Phe Ser Ser Ser Ser Ser Ser Ser Ser Gly Pro Arg Ser Phe Tyr Pro
            660                 665                 670         
Arg Gln Gly Ala Thr Ser Lys Tyr Leu Ile Gly Trp Lys Lys Pro Glu
        675                 680                 685             
Gly Thr Ile Asn Ser Val Gly Phe Met Asp Thr Arg Lys Arg His Gln
    690                 695                 700                 
Ser Asp Gly Asn Glu Ile Ala His Thr Arg Leu Arg Ala Ser Thr Arg
705                 710                 715                 720 
Asp Leu Arg Ala Ser Pro Lys Pro Thr Ser Lys Ser Thr Ile Glu Glu
                725                 730                 735     
Asp Leu Lys Lys Leu Ile Asp Leu Glu Ser Pro Thr Pro Glu Ser Gln
            740                 745                 750         
Lys Ser Phe Lys Phe His Ala Leu Ser Ser Pro Gln Ser Pro Phe Pro
        755                 760                 765             
Ser Thr Pro Thr Ser Arg Arg Ala Leu His Arg Thr Leu Ser Asp Glu
    770                 775                 780                 
Ser Ile Tyr Asn Ser Gln Arg Glu His Phe Phe Thr Ser Arg Ala Ser
785                 790                 795                 800 
Leu Leu Asp Gln Ala Leu Pro Asn Asp Val Leu Phe Ser Ser Thr Tyr
                805                 810                 815     
Pro Ser Leu Pro Lys Ser Leu Pro Leu Arg Arg Pro Ser Tyr Thr Leu
            820                 825                 830         
Gly Met Lys Ser Leu His Gly Glu Phe Ser Ala Ser Asp Ser Ser Leu
        835                 840                 845             
Thr Asp Ile Gln Glu Thr Arg Arg Gln Pro Met Pro Asp Pro Gly Leu
    850                 855                 860                 
Met Pro Leu Pro Asp Thr Ala Ala Asp Leu Asp Trp Ser Asn Leu Val
865                 870                 875                 880 
Asp Ala Ala Lys Ala Tyr Glu Val Gln Arg Ala Ser Phe Phe Ala Ala
                885                 890                 895     
Ser Asp Glu Asn His Arg Pro Leu Ser Ala Ala Ser Asn Ser Asp Gln
            900                 905                 910         
Leu Glu Asp Gln Ala Leu Ala Gln Met Lys Pro Tyr Ser Ser Ser Lys
        915                 920                 925             
Asp Ser Ser Pro Thr Leu Ala Ser Lys Val Asp Gln Leu Glu Gly Met
    930                 935                 940                 
Leu Lys Met Leu Arg Glu Asp Leu Lys Lys Glu Lys Glu Asp Lys Ala
945                 950                 955                 960 
His Leu Gln Ala Glu Val Gln His Leu Arg Glu Asp Asn Leu Arg Leu
                965                 970                 975     
Gln Glu Glu Ser Gln Asn Ala Ser Asp Lys Leu Lys Lys Phe Thr Glu
            980                 985                 990         
Trp Val Phe Asn Thr Ile Asp Met Ser
        995                 1000    


<210> 1689
<211> 1871
<212> PRT
<213> Homo sapiens

<400> 1689
Met Pro Ser Val Cys Leu Leu Leu Leu Leu Phe Leu Ala Val Gly Gly
 1               5                  10                  15      
Ala Leu Gly Asn Arg Pro Phe Arg Ala Phe Val Val Thr Asp Thr Thr
            20                  25                  30          
Leu Thr His Leu Ala Val His Arg Val Thr Gly Glu Val Phe Val Gly
        35                  40                  45              
Ala Val Asn Arg Val Phe Lys Leu Ala Pro Asn Leu Thr Glu Leu Arg
    50                  55                  60                  
Ala His Val Thr Gly Pro Val Glu Asp Asn Ala Arg Cys Tyr Pro Pro
65                  70                  75                  80  
Pro Ser Met Arg Val Cys Ala His Arg Leu Ala Pro Val Asp Asn Ile
                85                  90                  95      
Asn Lys Leu Leu Leu Ile Asp Tyr Ala Ala Arg Arg Leu Val Ala Cys
            100                 105                 110         
Gly Ser Ile Trp Gln Gly Ile Cys Gln Phe Leu Arg Leu Asp Asp Leu
        115                 120                 125             
Phe Lys Leu Gly Glu Pro His His Arg Lys Glu His Tyr Leu Ser Gly
    130                 135                 140                 
Ala Gln Glu Pro Asp Ser Met Ala Gly Val Ile Val Glu Gln Gly Gln
145                 150                 155                 160 
Gly Pro Ser Lys Leu Phe Val Gly Thr Ala Val Asp Gly Lys Ser Glu
                165                 170                 175     
Tyr Phe Pro Thr Leu Ser Ser Arg Lys Leu Ile Ser Asp Glu Asp Ser
            180                 185                 190         
Ala Asp Met Phe Ser Leu Val Tyr Gln Asp Glu Phe Val Ser Ser Gln
        195                 200                 205             
Ile Lys Ile Pro Ser Asp Thr Leu Ser Leu Tyr Pro Ala Phe Asp Ile
    210                 215                 220                 
Tyr Tyr Ile Tyr Gly Phe Val Ser Ala Ser Phe Val Tyr Phe Leu Thr
225                 230                 235                 240 
Leu Gln Leu Asp Thr Gln Gln Thr Leu Leu Asp Thr Ala Gly Glu Lys
                245                 250                 255     
Phe Phe Thr Ser Lys Ile Val Arg Met Cys Ala Gly Asp Ser Glu Phe
            260                 265                 270         
Tyr Ser Tyr Val Glu Phe Pro Ile Gly Cys Ser Trp Arg Gly Val Glu
        275                 280                 285             
Tyr Arg Leu Val Gln Ser Ala His Leu Ala Lys Pro Gly Leu Leu Leu
    290                 295                 300                 
Ala Gln Ala Leu Gly Val Pro Ala Asp Glu Asp Val Leu Phe Thr Ile
305                 310                 315                 320 
Phe Ser Gln Gly Gln Lys Asn Arg Ala Ser Pro Pro Arg Gln Thr Ile
                325                 330                 335     
Leu Cys Leu Phe Thr Leu Ser Asn Ile Asn Ala His Ile Arg Arg Arg
            340                 345                 350         
Ile Gln Ser Cys Tyr Arg Gly Glu Gly Thr Leu Ala Leu Pro Trp Leu
        355                 360                 365             
Leu Asn Lys Glu Leu Pro Cys Ile Asn Thr Pro Met Gln Ile Asn Gly
    370                 375                 380                 
Asn Phe Cys Gly Leu Val Leu Asn Gln Pro Leu Gly Gly Leu His Val
385                 390                 395                 400 
Ile Glu Gly Leu Pro Leu Leu Ala Asp Ser Thr Asp Gly Met Ala Ser
                405                 410                 415     
Val Ala Ala Tyr Thr Tyr Arg Gln His Ser Val Val Phe Ile Gly Thr
            420                 425                 430         
Arg Ser Gly Ser Leu Lys Lys Val Arg Val Asp Gly Phe Gln Asp Ala
        435                 440                 445             
His Leu Tyr Glu Thr Val Pro Val Val Asp Gly Ser Pro Ile Leu Arg
    450                 455                 460                 
Asp Leu Leu Phe Ser Pro Asp His Arg His Ile Tyr Leu Leu Ser Glu
465                 470                 475                 480 
Lys Gln Val Ser Gln Leu Pro Val Glu Thr Cys Glu Gln Tyr Gln Ser
                485                 490                 495     
Cys Ala Ala Cys Leu Gly Ser Gly Asp Pro His Cys Gly Trp Cys Val
            500                 505                 510         
Leu Arg His Arg Cys Cys Arg Glu Gly Ala Cys Leu Gly Ala Ser Ala
        515                 520                 525             
Pro His Gly Phe Ala Glu Glu Leu Ser Lys Cys Val Gln Val Arg Val
    530                 535                 540                 
Arg Pro Asn Asn Val Ser Val Thr Ser Pro Gly Val Gln Leu Thr Val
545                 550                 555                 560 
Thr Leu His Asn Val Pro Asp Leu Ser Ala Gly Val Ser Cys Ala Phe
                565                 570                 575     
Glu Ala Ala Ala Glu Asn Glu Ala Val Leu Leu Pro Ser Gly Glu Leu
            580                 585                 590         
Leu Cys Pro Ser Pro Ser Leu Gln Glu Leu Arg Ala Leu Thr Arg Gly
        595                 600                 605             
His Gly Ala Thr Arg Thr Val Arg Leu Gln Leu Leu Ser Lys Glu Thr
    610                 615                 620                 
Gly Val Arg Phe Ala Gly Ala Asp Phe Val Phe Tyr Asn Cys Ser Val
625                 630                 635                 640 
Leu Gln Ser Cys Met Ser Cys Val Gly Ser Pro Tyr Pro Cys His Trp
                645                 650                 655     
Cys Lys Tyr Arg His Thr Cys Thr Ser Arg Pro His Glu Cys Ser Phe
            660                 665                 670         
Gln Glu Gly Arg Val His Ser Pro Glu Gly Cys Pro Glu Ile Leu Pro
        675                 680                 685             
Ser Gly Asp Leu Leu Ile Pro Val Gly Val Met Gln Pro Leu Thr Leu
    690                 695                 700                 
Arg Ala Lys Asn Leu Pro Gln Pro Gln Ser Gly Gln Lys Asn Tyr Glu
705                 710                 715                 720 
Cys Val Val Arg Val Gln Gly Arg Gln Gln Arg Val Pro Ala Val Arg
                725                 730                 735     
Phe Asn Ser Ser Ser Val Gln Cys Gln Asn Ala Ser Tyr Ser Tyr Glu
            740                 745                 750         
Gly Asp Glu His Gly Asp Thr Glu Leu Asp Phe Ser Val Val Trp Asp
        755                 760                 765             
Gly Asp Phe Pro Ile Asp Lys Pro Pro Ser Phe Arg Ala Leu Leu Tyr
    770                 775                 780                 
Lys Cys Trp Ala Gln Arg Pro Ser Cys Gly Leu Cys Leu Lys Ala Asp
785                 790                 795                 800 
Pro Arg Phe Asn Cys Gly Trp Cys Ile Ser Glu His Arg Cys Gln Leu
                805                 810                 815     
Arg Thr His Cys Pro Ala Pro Lys Thr Asn Trp Met His Leu Ser Gln
            820                 825                 830         
Lys Gly Thr Arg Cys Ser His Pro Arg Ile Thr Gln Ile His Pro Leu
        835                 840                 845             
Val Gly Pro Lys Glu Gly Gly Thr Arg Val Thr Ile Val Gly Asp Asn
    850                 855                 860                 
Leu Gly Leu Leu Ser Arg Glu Val Gly Leu Arg Val Ala Gly Val Arg
865                 870                 875                 880 
Cys Asn Ser Ile Pro Ala Glu Tyr Ile Ser Ala Glu Arg Ile Val Cys
                885                 890                 895     
Glu Met Glu Glu Ser Leu Val Pro Ser Pro Pro Pro Gly Pro Val Glu
            900                 905                 910         
Leu Cys Val Gly Asp Cys Ser Ala Asp Phe Arg Thr Gln Ser Glu Gln
        915                 920                 925             
Val Tyr Ser Phe Val Thr Pro Thr Phe Asp Gln Val Ser Pro Ser Arg
    930                 935                 940                 
Gly Pro Ala Ser Gly Gly Thr Arg Leu Thr Ile Ser Gly Ser Ser Leu
945                 950                 955                 960 
Asp Ala Gly Ser Arg Val Thr Val Thr Val Arg Asp Ser Glu Cys Gln
                965                 970                 975     
Phe Val Arg Arg Asp Ala Lys Ala Ile Val Cys Ile Ser Pro Leu Ser
            980                 985                 990         
Thr Leu Gly Pro Ser Gln Ala Pro Ile Thr Leu Ala Ile Asp Arg Ala
        995                 1000                1005            
Asn Ile Ser Ser Pro Gly Leu Ile Tyr Thr Tyr Thr Gln Asp Pro Thr
    1010                1015                1020                
Val Thr Arg Leu Glu Pro Thr Trp Ser Ile Ile Asn Gly Ser Thr Ala
1025                1030                1035                1040
Ile Thr Val Ser Gly Thr His Leu Leu Thr Val Gln Glu Pro Arg Val
                1045                1050                1055    
Arg Ala Lys Tyr Arg Gly Ile Glu Thr Thr Asn Thr Cys Gln Val Ile
            1060                1065                1070        
Asn Asp Thr Ala Met Leu Cys Lys Ala Pro Gly Ile Phe Leu Gly Arg
        1075                1080                1085            
Pro Gln Pro Arg Ala Gln Gly Glu His Pro Asp Glu Phe Gly Phe Leu
    1090                1095                1100                
Leu Asp His Val Gln Thr Ala Arg Ser Leu Asn Arg Ser Ser Phe Thr
1105                1110                1115                1120
Tyr Tyr Pro Asp Pro Ser Phe Glu Pro Leu Gly Pro Ser Gly Val Leu
                1125                1130                1135    
Asp Val Lys Pro Gly Ser His Val Val Leu Lys Gly Lys Asn Leu Ile
            1140                1145                1150        
Pro Ala Ala Ala Gly Ser Ser Arg Leu Asn Tyr Thr Val Leu Ile Gly
        1155                1160                1165            
Gly Gln Pro Cys Ser Leu Thr Val Ser Asp Thr Gln Leu Leu Cys Asp
    1170                1175                1180                
Ser Pro Ser Gln Thr Gly Arg Gln Pro Val Met Val Leu Val Gly Gly
1185                1190                1195                1200
Leu Glu Phe Trp Leu Gly Thr Leu His Ile Ser Ala Glu Arg Ala Leu
                1205                1210                1215    
Thr Leu Pro Ala Met Met Gly Leu Ala Ala Gly Gly Gly Leu Leu Leu
            1220                1225                1230        
Leu Ala Ile Thr Ala Val Leu Val Ala Tyr Lys Arg Lys Thr Gln Asp
        1235                1240                1245            
Ala Asp Arg Thr Leu Lys Arg Leu Gln Leu Gln Met Asp Asn Leu Glu
    1250                1255                1260                
Ser Arg Val Ala Leu Glu Cys Lys Glu Ala Phe Ala Glu Leu Gln Thr
1265                1270                1275                1280
Asp Ile Asn Glu Leu Thr Asn His Met Asp Glu Val Gln Ile Pro Phe
                1285                1290                1295    
Leu Asp Tyr Arg Thr Tyr Ala Val Arg Val Leu Phe Pro Gly Ile Glu
            1300                1305                1310        
Ala His Pro Val Leu Lys Glu Leu Asp Thr Pro Pro Asn Val Glu Lys
        1315                1320                1325            
Ala Leu Arg Leu Phe Gly Gln Leu Leu His Ser Arg Ala Phe Val Leu
    1330                1335                1340                
Thr Phe Ile His Thr Leu Glu Ala Gln Ser Ser Phe Ser Met Arg Asp
1345                1350                1355                1360
Arg Gly Thr Val Ala Ser Leu Thr Met Val Ala Leu Gln Ser Arg Leu
                1365                1370                1375    
Asp Tyr Ala Thr Gly Leu Leu Lys Gln Leu Leu Ala Asp Leu Ile Glu
            1380                1385                1390        
Lys Asn Leu Glu Ser Lys Asn His Pro Lys Leu Leu Leu Arg Arg Thr
        1395                1400                1405            
Glu Ser Val Ala Glu Lys Met Leu Thr Asn Trp Phe Thr Phe Leu Leu
    1410                1415                1420                
His Lys Phe Leu Lys Glu Cys Ala Gly Glu Pro Leu Phe Leu Leu Tyr
1425                1430                1435                1440
Cys Ala Ile Lys Gln Gln Met Glu Lys Gly Pro Ile Asp Ala Ile Thr
                1445                1450                1455    
Gly Glu Ala Arg Tyr Ser Leu Ser Glu Asp Lys Leu Ile Arg Gln Gln
            1460                1465                1470        
Ile Asp Tyr Lys Thr Leu Thr Leu His Cys Val Cys Pro Glu Asn Glu
        1475                1480                1485            
Gly Ser Ala Gln Val Pro Val Lys Val Leu Asn Cys Asp Ser Ile Thr
    1490                1495                1500                
Gln Ala Lys Asp Lys Leu Leu Asp Thr Val Tyr Lys Gly Ile Pro Tyr
1505                1510                1515                1520
Ser Gln Arg Pro Lys Ala Glu Asp Met Asp Leu Glu Trp Arg Gln Gly
                1525                1530                1535    
Arg Met Thr Arg Ile Ile Leu Gln Asp Glu Asp Val Thr Thr Lys Ile
            1540                1545                1550        
Glu Cys Asp Trp Lys Arg Leu Asn Ser Leu Ala His Tyr Gln Val Thr
        1555                1560                1565            
Asp Gly Ser Leu Val Ala Leu Val Pro Lys Gln Val Ser Ala Tyr Asn
    1570                1575                1580                
Met Ala Asn Ser Phe Thr Phe Thr Arg Ser Leu Ser Arg Tyr Glu Ser
1585                1590                1595                1600
Leu Leu Arg Thr Ala Ser Ser Pro Asp Ser Leu Arg Ser Arg Ala Pro
                1605                1610                1615    
Met Ile Thr Pro Asp Gln Glu Thr Gly Thr Lys Leu Trp His Leu Val
            1620                1625                1630        
Lys Asn His Asp His Ala Asp His Arg Glu Gly Asp Arg Gly Ser Lys
        1635                1640                1645            
Met Val Ser Glu Ile Tyr Leu Thr Arg Leu Leu Ala Thr Lys Gly Thr
    1650                1655                1660                
Leu Gln Lys Phe Val Asp Asp Leu Phe Glu Thr Val Phe Ser Thr Ala
1665                1670                1675                1680
His Arg Gly Ser Ala Leu Pro Leu Ala Ile Lys Tyr Met Phe Asp Phe
                1685                1690                1695    
Leu Asp Glu Gln Ala Asp Gln Arg Gln Ile Ser Asp Pro Asp Val Arg
            1700                1705                1710        
His Thr Trp Lys Ser Asn Cys Leu Pro Leu Arg Phe Trp Val Asn Val
        1715                1720                1725            
Ile Lys Asn Pro Gln Phe Val Phe Asp Ile His Lys Asn Ser Ile Thr
    1730                1735                1740                
Asp Ala Cys Leu Ser Val Val Ala Gln Thr Phe Met Asp Ser Cys Ser
1745                1750                1755                1760
Thr Ser Glu His Arg Leu Gly Lys Asp Ser Pro Ser Asn Lys Leu Leu
                1765                1770                1775    
Tyr Ala Lys Asp Ile Pro Asn Tyr Lys Ser Trp Val Glu Arg Tyr Tyr
            1780                1785                1790        
Arg Asp Ile Ala Lys Met Ala Ser Ile Ser Asp Gln Asp Met Asp Ala
        1795                1800                1805            
Tyr Leu Val Glu Gln Ser Arg Leu His Ala Ser Asp Phe Ser Val Leu
    1810                1815                1820                
Ser Ala Leu Asn Glu Leu Tyr Phe Tyr Val Thr Lys Tyr Arg Gln Glu
1825                1830                1835                1840
Ile Leu Thr Ala Leu Asp Arg Asp Ala Ser Cys Arg Lys His Lys Leu
                1845                1850                1855    
Arg Gln Lys Leu Glu Gln Ile Ile Ser Leu Val Ser Ser Asp Ser
            1860                1865                1870    


<210> 1690
<211> 248
<212> PRT
<213> Homo sapiens

<400> 1690
Met Arg Met Asp Trp Asn Leu Gln Ala Gln Ala Gln Pro Thr Gln Thr
 1               5                  10                  15      
Thr Lys Val Thr Gly Ser Leu Glu Thr Lys Tyr Arg Trp Thr Glu Tyr
            20                  25                  30          
Gly Leu Thr Phe Thr Glu Lys Trp Asn Thr Asp Asn Thr Leu Gly Thr
        35                  40                  45              
Lys Ile Thr Val Glu Asp Gln Leu Ala Arg Gly Leu Lys Leu Thr Phe
    50                  55                  60                  
Asp Ser Ser Phe Ser Pro Asn Thr Gly Lys Lys Asn Ala Lys Ile Lys
65                  70                  75                  80  
Thr Gly Tyr Lys Arg Glu His Ile Asn Leu Gly Cys Asp Met Val Phe
                85                  90                  95      
Asp Ile Val Gly Pro Ser Ile Arg Gly Ala Leu Val Leu Gly Tyr Glu
            100                 105                 110         
Gly Trp Leu Ala Gly Tyr Gln Met Asn Phe Glu Thr Thr Lys Ser Arg
        115                 120                 125             
Val Thr Gln Ser Asn Phe Ala Ile Gly Tyr Lys Thr Asp Glu Phe Gln
    130                 135                 140                 
Leu His Thr Asn Val Asn Asp Gly Thr Glu Phe Gly Gly Ser Ile Tyr
145                 150                 155                 160 
Gln Lys Val Asn Lys Lys Leu Glu Thr Thr Val Asn Leu Ala Trp Thr
                165                 170                 175     
Ala Gly Asn Ser Asn Thr Arg Phe Gly Ile Ala Ala Lys Tyr Gln Ile
            180                 185                 190         
Asp Pro Asp Ala Cys Phe Ser Ala Lys Val Asn Asn Ser Ser Leu Ile
        195                 200                 205             
Gly Leu Gly Tyr Thr Gln Thr Leu Lys Pro Gly Ile Lys Leu Thr Leu
    210                 215                 220                 
Ser Ala Leu Leu Asp Gly Lys Asn Val Asn Ala Gly Gly His Lys Leu
225                 230                 235                 240 
Gly Leu Gly Leu Glu Phe Gln Ala
                245             


<210> 1691
<211> 129
<212> PRT
<213> Homo sapiens

<400> 1691
Met Asn Phe Glu Thr Ala Lys Ser Arg Val Thr Gln Ser Asn Phe Ala
 1               5                  10                  15      
Val Gly Tyr Glu Thr Asp Glu Phe Trp Leu His Thr Asn Val Asn Asp
            20                  25                  30          
Gly Thr Glu Phe Gly Ser Leu Ile Tyr Gln Lys Val Asn Lys Lys Leu
        35                  40                  45              
Glu Thr Ala Val Asn Leu Ala Trp Thr Ala Gly Asn Ser Asn Thr Arg
    50                  55                  60                  
Phe Gly Ile Ala Ala Lys Tyr Gln Ile Asp Pro Asp Ala Cys Phe Ser
65                  70                  75                  80  
Ala Lys Val Asn Asn Ser Ser Leu Ile Gly Leu Gly Tyr Thr Gln Thr
                85                  90                  95      
Leu Lys Pro Gly Ile Lys Leu Thr Leu Ser Ala Leu Leu Asp Gly Lys
            100                 105                 110         
Asn Val Asn Ala Gly Gly His Lys Leu Gly Leu Gly Leu Glu Phe Gln
        115                 120                 125             
Ala
    


<210> 1692
<211> 111
<212> PRT
<213> Homo sapiens

<400> 1692
Met Ala Gly Lys Gln Ala Ile Ser Ala Ser Gly Lys Trp Leu Asp Gly
 1               5                  10                  15      
Ile Arg Lys Trp Tyr Tyr Asn Thr Ala Gly Phe Asn Lys Leu Gly Leu
            20                  25                  30          
Met Arg Asp Asp Thr Ile Tyr Glu Asp Glu Asp Ile Lys Glu Ala Ile
        35                  40                  45              
Arg Arg Leu Pro Glu Asn Leu Tyr Asn Asp Arg Met Cys His Ile Lys
    50                  55                  60                  
Ser Ala Leu Asp Leu Thr Met Lys His Gln Ile Leu Pro Lys Glu Gln
65                  70                  75                  80  
Trp Thr Lys Tyr Glu Glu Glu Asn Phe Tyr Leu Glu Leu Tyr Val Gln
                85                  90                  95      
Glu Val Ile Arg Glu Arg Lys Glu Arg Glu Glu Trp Ala Lys Lys
            100                 105                 110     


<210> 1693
<211> 639
<212> PRT
<213> Homo sapiens

<400> 1693
Met Ser Ala Arg Gly Pro Ala Ile Gly Ile Asp Leu Gly Thr Thr Tyr
 1               5                  10                  15      
Ser Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn
            20                  25                  30          
Asp Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr
        35                  40                  45              
Glu Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Met Asn Pro
    50                  55                  60                  
Thr Asn Thr Ile Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe Glu
65                  70                  75                  80  
Asp Ala Thr Val Gln Ser Asp Met Lys His Trp Pro Phe Arg Val Val
                85                  90                  95      
Ser Glu Gly Gly Lys Pro Lys Val Gln Val Glu Tyr Lys Gly Glu Thr
            100                 105                 110         
Lys Thr Phe Phe Pro Glu Glu Ile Ser Ser Met Val Leu Thr Lys Met
        115                 120                 125             
Lys Glu Ile Ala Glu Ala Tyr Leu Gly Gly Lys Val His Ser Ala Val
    130                 135                 140                 
Ile Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys
145                 150                 155                 160 
Asp Ala Gly Thr Ile Thr Gly Leu Asn Val Leu Arg Ile Ile Asn Glu
                165                 170                 175     
Pro Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Lys Lys Gly Cys Ala
            180                 185                 190         
Gly Gly Glu Lys Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe
        195                 200                 205             
Asp Val Ser Ile Leu Thr Ile Glu Asp Gly Ile Phe Glu Val Lys Ser
    210                 215                 220                 
Thr Ala Gly Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Met
225                 230                 235                 240 
Val Ser His Leu Ala Glu Glu Phe Lys Arg Lys His Lys Lys Asp Ile
                245                 250                 255     
Gly Pro Asn Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg
            260                 265                 270         
Ala Lys Arg Thr Leu Ser Ser Ser Thr Gln Ala Ser Ile Glu Ile Asp
        275                 280                 285             
Ser Leu Tyr Glu Gly Val Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg
    290                 295                 300                 
Phe Glu Glu Leu Asn Ala Asp Leu Phe Arg Gly Thr Leu Glu Pro Val
305                 310                 315                 320 
Glu Lys Ala Leu Arg Asp Ala Lys Leu Asp Lys Gly Gln Ile Gln Glu
                325                 330                 335     
Ile Val Leu Val Gly Gly Ser Thr Arg Ile Pro Lys Ile Gln Lys Leu
            340                 345                 350         
Leu Gln Asp Phe Phe Asn Gly Lys Glu Leu Asn Lys Ser Ile Asn Pro
        355                 360                 365             
Asp Glu Ala Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Ile
    370                 375                 380                 
Gly Asp Lys Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Thr
385                 390                 395                 400 
Pro Leu Ser Leu Gly Ile Glu Thr Ala Gly Gly Val Met Thr Pro Leu
                405                 410                 415     
Ile Lys Arg Asn Thr Thr Ile Pro Thr Lys Gln Thr Gln Thr Phe Thr
            420                 425                 430         
Thr Tyr Ser Asp Asn Gln Ser Ser Val Leu Val Gln Val Tyr Glu Gly
        435                 440                 445             
Glu Arg Ala Met Thr Lys Asp Asn Asn Leu Leu Gly Lys Phe Asp Leu
    450                 455                 460                 
Thr Gly Ile Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr
465                 470                 475                 480 
Phe Asp Ile Asp Ala Asn Gly Ile Leu Asn Val Thr Ala Ala Asp Lys
                485                 490                 495     
Ser Thr Gly Lys Glu Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg
            500                 505                 510         
Leu Ser Lys Asp Asp Ile Asp Arg Met Val Gln Glu Ala Glu Arg Tyr
        515                 520                 525             
Lys Ser Glu Asp Glu Ala Asn Arg Asp Arg Val Ala Ala Lys Asn Ala
    530                 535                 540                 
Leu Glu Ser Tyr Thr Tyr Asn Ile Lys Gln Thr Val Glu Asp Glu Lys
545                 550                 555                 560 
Leu Arg Gly Lys Ile Ser Glu Gln Asp Lys Asn Lys Ile Leu Asp Lys
                565                 570                 575     
Cys Gln Glu Val Ile Asn Trp Leu Asp Arg Asn Gln Met Ala Glu Lys
            580                 585                 590         
Asp Glu Tyr Glu His Lys Gln Lys Glu Leu Glu Arg Val Cys Asn Pro
        595                 600                 605             
Ile Ile Ser Lys Leu Tyr Gln Gly Gly Pro Gly Gly Gly Ser Gly Gly
    610                 615                 620                 
Gly Gly Ser Gly Ala Ser Gly Gly Pro Thr Ile Glu Glu Val Asp
625                 630                 635                 


<210> 1694
<211> 558
<212> PRT
<213> Homo sapiens

<400> 1694
Met Tyr Arg Tyr Leu Ala Lys Ala Leu Leu Pro Ser Arg Ala Gly Pro
 1               5                  10                  15      
Ala Ala Leu Gly Ser Ala Ala Asn His Ser Ala Ala Leu Leu Gly Arg
            20                  25                  30          
Gly Arg Gly Gln Pro Ala Ala Ala Ser Gln Pro Gly Leu Ala Leu Ala
        35                  40                  45              
Ala Arg Arg His Tyr Ser Glu Leu Val Ala Asp Arg Glu Asp Asp Pro
    50                  55                  60                  
Asn Phe Phe Lys Met Val Glu Gly Phe Phe Asp Arg Gly Ala Ser Ile
65                  70                  75                  80  
Val Glu Asp Lys Leu Val Lys Asp Leu Arg Thr Gln Glu Ser Glu Glu
                85                  90                  95      
Gln Lys Arg Asn Arg Val Arg Gly Ile Leu Arg Ile Ile Lys Pro Cys
            100                 105                 110         
Asn His Val Leu Ser Leu Ser Phe Pro Ile Arg Arg Asp Asp Gly Ser
        115                 120                 125             
Trp Glu Val Ile Glu Gly Tyr Arg Ala Gln His Ser Gln His Arg Thr
    130                 135                 140                 
Pro Cys Lys Gly Gly Ile Arg Tyr Ser Thr Asp Val Ser Val Asp Glu
145                 150                 155                 160 
Val Lys Ala Leu Ala Ser Leu Met Thr Tyr Lys Cys Ala Val Val Asp
                165                 170                 175     
Val Pro Phe Gly Gly Ala Lys Ala Gly Val Lys Ile Asn Pro Lys Asn
            180                 185                 190         
Tyr Thr Glu Asn Glu Leu Glu Lys Ile Thr Arg Arg Phe Thr Met Glu
        195                 200                 205             
Leu Ala Lys Lys Gly Phe Ile Gly Pro Gly Val Asp Val Pro Ala Pro
    210                 215                 220                 
Asp Met Asn Thr Gly Glu Arg Glu Met Ser Trp Ile Ala Asp Thr Tyr
225                 230                 235                 240 
Ala Ser Thr Ile Gly His Tyr Asp Ile Asn Ala His Ala Cys Val Thr
                245                 250                 255     
Gly Lys Pro Ile Ser Gln Gly Gly Ile His Gly Arg Ile Ser Ala Thr
            260                 265                 270         
Gly Arg Gly Val Phe His Gly Ile Glu Asn Phe Ile Asn Glu Ala Ser
        275                 280                 285             
Tyr Met Ser Ile Leu Gly Met Thr Pro Gly Phe Arg Asp Lys Thr Phe
    290                 295                 300                 
Val Val Gln Gly Phe Gly Asn Val Gly Leu His Ser Met Arg Tyr Leu
305                 310                 315                 320 
His Arg Phe Gly Ala Lys Cys Ile Ala Val Gly Glu Ser Asp Gly Ser
                325                 330                 335     
Ile Trp Asn Pro Asp Gly Ile Asp Pro Lys Glu Leu Glu Asp Phe Lys
            340                 345                 350         
Leu Gln His Gly Ser Ile Leu Gly Phe Pro Lys Ala Lys Pro Tyr Glu
        355                 360                 365             
Gly Ser Ile Leu Glu Val Asp Cys Asp Ile Leu Ile Pro Ala Ala Thr
    370                 375                 380                 
Glu Lys Gln Leu Thr Lys Ser Asn Ala Pro Arg Val Lys Ala Lys Ile
385                 390                 395                 400 
Ile Ala Glu Gly Ala Asn Gly Pro Thr Thr Pro Glu Ala Asp Lys Ile
                405                 410                 415     
Phe Leu Glu Arg Asn Ile Leu Val Ile Pro Asp Leu Tyr Leu Asn Ala
            420                 425                 430         
Gly Gly Val Thr Val Ser Tyr Phe Glu Trp Leu Lys Asn Leu Asn His
        435                 440                 445             
Val Ser Tyr Gly Arg Leu Thr Phe Lys Tyr Glu Arg Asp Ser Asn Tyr
    450                 455                 460                 
His Leu Leu Leu Ser Val Gln Glu Ser Leu Glu Arg Lys Phe Gly Lys
465                 470                 475                 480 
His Gly Gly Thr Ile Pro Ile Val Pro Thr Ala Glu Phe Gln Asp Ser
                485                 490                 495     
Ile Ser Gly Ala Ser Glu Lys Asp Ile Val His Ser Ala Leu Ala Tyr
            500                 505                 510         
Thr Met Glu Arg Ser Ala Arg Gln Ile Met His Thr Ala Met Lys Tyr
        515                 520                 525             
Asn Leu Gly Leu Asp Leu Arg Thr Ala Ala Tyr Val Asn Ala Ile Glu
    530                 535                 540                 
Lys Val Phe Lys Val Tyr Ser Glu Ala Gly Val Thr Phe Thr
545                 550                 555             


<210> 1695
<211> 347
<212> PRT
<213> Homo sapiens

<400> 1695
Met Pro Arg Gly Gln Lys Ser Lys Leu Arg Ala Arg Glu Lys Arg Arg
 1               5                  10                  15      
Lys Ala Arg Glu Glu Thr Gln Gly Leu Lys Val Ala His Ala Thr Ala
            20                  25                  30          
Ala Glu Lys Glu Glu Cys Pro Ser Ser Ser Pro Val Leu Gly Asp Thr
        35                  40                  45              
Pro Thr Ser Ser Pro Ala Ala Gly Ile Pro Gln Lys Pro Gln Gly Ala
    50                  55                  60                  
Pro Pro Thr Thr Thr Ala Ala Ala Ala Val Ser Cys Thr Glu Ser Asp
65                  70                  75                  80  
Glu Gly Ala Lys Cys Gln Gly Glu Glu Asn Ala Ser Phe Ser Gln Ala
                85                  90                  95      
Thr Thr Ser Thr Glu Ser Ser Val Lys Asp Pro Val Ala Trp Glu Ala
            100                 105                 110         
Gly Met Leu Met His Phe Ile Leu Arg Lys Tyr Lys Met Arg Glu Pro
        115                 120                 125             
Ile Met Lys Ala Asp Met Leu Lys Val Val Asp Glu Lys Tyr Lys Asp
    130                 135                 140                 
His Phe Thr Glu Ile Leu Asn Gly Ala Ser Arg Arg Leu Glu Leu Val
145                 150                 155                 160 
Phe Gly Leu Asp Leu Lys Glu Asp Asn Pro Ser Gly His Thr Tyr Thr
                165                 170                 175     
Leu Val Ser Lys Leu Asn Leu Thr Asn Asp Gly Asn Leu Ser Asn Asp
            180                 185                 190         
Trp Asp Phe Pro Arg Asn Gly Leu Leu Met Pro Leu Leu Gly Val Ile
        195                 200                 205             
Phe Leu Lys Gly Asn Ser Ala Thr Glu Glu Glu Ile Trp Lys Phe Met
    210                 215                 220                 
Asn Val Leu Gly Ala Tyr Asp Gly Glu Glu His Leu Ile Tyr Gly Glu
225                 230                 235                 240 
Pro Arg Lys Phe Ile Thr Gln Asp Leu Val Gln Glu Lys Tyr Leu Lys
                245                 250                 255     
Tyr Glu Gln Val Pro Asn Ser Asp Pro Pro Arg Tyr Gln Phe Leu Trp
            260                 265                 270         
Gly Pro Arg Ala Tyr Ala Glu Thr Thr Lys Met Lys Val Leu Glu Phe
        275                 280                 285             
Leu Ala Lys Met Asn Gly Ala Thr Pro Arg Asp Phe Pro Ser His Tyr
    290                 295                 300                 
Glu Glu Ala Leu Arg Asp Glu Glu Glu Arg Ala Gln Val Arg Ser Ser
305                 310                 315                 320 
Val Arg Ala Arg Arg Arg Thr Thr Ala Thr Thr Phe Arg Ala Arg Ser
                325                 330                 335     
Arg Ala Pro Phe Ser Arg Ser Ser His Pro Met
            340                 345         


<210> 1696
<211> 1893
<212> PRT
<213> Homo sapiens

<400> 1696
Met Gly Ser Gln Arg Val Ala Ala Cys Arg Leu Leu Ala Glu Ser Leu
 1               5                  10                  15      
Leu Glu Arg Gly His Ser Ala Gly Pro Met Val Arg Gln Arg Gln Gln
            20                  25                  30          
Asp Leu Gln Thr Ala Trp Ser Glu Leu Trp Glu Leu Thr Gln Ala Arg
        35                  40                  45              
Gly His Ala Leu Arg Asp Thr Glu Thr Thr Leu Arg Val His Arg Asp
    50                  55                  60                  
Leu Leu Glu Val Leu Thr Gln Val Gln Glu Lys Ala Thr Ser Leu Pro
65                  70                  75                  80  
Asn Asn Val Ala Arg Asp Leu Cys Gly Leu Glu Ala Gln Leu Arg Ser
                85                  90                  95      
His Gln Gly Leu Glu Arg Glu Leu Val Gly Thr Glu Arg Gln Leu Gln
            100                 105                 110         
Glu Leu Leu Glu Thr Ala Gly Arg Val Gln Lys Leu Cys Pro Gly Pro
        115                 120                 125             
Gln Ala His Ala Val Gln Gln Arg Gln Gln Ala Val Thr Gln Ala Trp
    130                 135                 140                 
Ala Val Leu Gln Arg Arg Met Glu Gln Arg Arg Ala Gln Leu Glu Arg
145                 150                 155                 160 
Ala Arg Leu Leu Ala Arg Phe Arg Thr Ala Val Arg Asp Tyr Ala Ser
                165                 170                 175     
Trp Ala Ala Arg Val Arg Gln Asp Leu Gln Val Glu Glu Ser Ser Gln
            180                 185                 190         
Glu Pro Ser Ser Gly Pro Leu Lys Leu Ser Ala His Gln Trp Leu Arg
        195                 200                 205             
Ala Glu Leu Glu Ala Arg Glu Lys Leu Trp Gln Gln Ala Thr Gln Leu
    210                 215                 220                 
Gly Gln Gln Ala Leu Leu Ala Ala Gly Thr Pro Thr Lys Glu Val Gln
225                 230                 235                 240 
Glu Glu Leu Arg Ala Leu Gln Asp Gln Arg Asp Gln Val Tyr Gln Thr
                245                 250                 255     
Trp Ala Arg Lys Gln Glu Arg Leu Gln Ala Glu Gln Gln Glu Gln Leu
            260                 265                 270         
Phe Leu Arg Glu Cys Gly Arg Leu Glu Glu Ile Leu Ala Ala Gln Glu
        275                 280                 285             
Val Ser Leu Lys Thr Ser Ala Leu Gly Ser Ser Val Glu Glu Val Glu
    290                 295                 300                 
Gln Leu Ile Arg Lys His Glu Val Phe Leu Lys Val Leu Thr Ala Gln
305                 310                 315                 320 
Asp Lys Lys Glu Ala Ala Leu Arg Glu Arg Leu Lys Thr Leu Arg Arg
                325                 330                 335     
Pro Arg Val Arg Asp Arg Leu Pro Ile Leu Leu Gln Arg Arg Met Arg
            340                 345                 350         
Val Lys Glu Leu Ala Glu Ser Arg Gly His Ala Leu His Ala Ser Leu
        355                 360                 365             
Leu Met Ala Ser Phe Thr Gln Ala Ala Thr Gln Ala Glu Asp Trp Ile
    370                 375                 380                 
Gln Ala Trp Ala Gln Gln Leu Lys Glu Pro Val Pro Pro Gly Asp Leu
385                 390                 395                 400 
Arg Asp Lys Leu Lys Pro Leu Leu Lys His Gln Ala Phe Glu Ala Glu
                405                 410                 415     
Val Gln Ala His Glu Glu Val Met Thr Ser Val Ala Lys Lys Gly Glu
            420                 425                 430         
Ala Leu Leu Ala Gln Ser His Pro Arg Ala Gly Glu Val Ser Gln Arg
        435                 440                 445             
Leu Gln Gly Leu Arg Lys His Trp Glu Asp Leu Arg Gln Ala Met Ala
    450                 455                 460                 
Leu Arg Gly Gln Glu Leu Glu Asp Arg Arg Asn Phe Leu Glu Phe Leu
465                 470                 475                 480 
Gln Arg Val Asp Leu Ala Glu Ala Trp Ile Gln Glu Lys Glu Val Lys
                485                 490                 495     
Met Asn Val Gly Asp Leu Gly Gln Asp Leu Glu His Cys Leu Gln Leu
            500                 505                 510         
Arg Arg Arg Leu Arg Glu Phe Arg Gly Asn Ser Ala Gly Asp Thr Val
        515                 520                 525             
Gly Asp Ala Cys Ile Arg Ser Ile Ser Asp Leu Ser Leu Gln Leu Lys
    530                 535                 540                 
Asn Arg Asp Pro Glu Glu Val Lys Ile Ile Cys Gln Arg Arg Ser Gln
545                 550                 555                 560 
Leu Asn Asn Arg Trp Ala Ser Phe His Gly Asn Leu Leu Arg Tyr Gln
                565                 570                 575     
Gln Gln Leu Glu Gly Ala Leu Glu Ile His Val Leu Ser Arg Glu Leu
            580                 585                 590         
Asp Asn Val Thr Lys Arg Ile Gln Glu Lys Glu Ala Leu Ile Gln Ala
        595                 600                 605             
Leu Asp Cys Gly Lys Asp Leu Glu Ser Val Gln Arg Leu Leu Arg Lys
    610                 615                 620                 
His Glu Glu Leu Glu Arg Glu Val His Pro Ile Gln Ala Gln Val Glu
625                 630                 635                 640 
Ser Leu Glu Arg Glu Val Gly Arg Leu Cys Gln Arg Ser Pro Glu Ala
                645                 650                 655     
Ala His Gly Leu Arg His Arg Gln Gln Glu Val Ala Glu Ser Trp Trp
            660                 665                 670         
Gln Leu Arg Ser Arg Ala Gln Lys Arg Arg Glu Ala Leu Asp Ala Leu
        675                 680                 685             
His Gln Ala Gln Lys Leu Gln Ala Met Leu Gln Glu Leu Leu Val Ser
    690                 695                 700                 
Ala Gln Arg Leu Arg Ala Gln Met Asp Thr Ser Pro Ala Pro Arg Ser
705                 710                 715                 720 
Pro Val Glu Ala Arg Arg Met Leu Glu Glu His Gln Glu Cys Lys Ala
                725                 730                 735     
Glu Leu Asp Ser Trp Thr Asp Ser Ile Ser Leu Ala Arg Ser Thr Gly
            740                 745                 750         
Gln Gln Leu Leu Thr Ala Gly His Pro Phe Ser Ser Asp Ile Arg Gln
        755                 760                 765             
Val Leu Ala Gly Leu Glu Gln Glu Leu Ser Ser Leu Glu Gly Ala Trp
    770                 775                 780                 
Gln Glu His Gln Leu Gln Leu Gln Gln Ala Leu Glu Leu Gln Leu Phe
785                 790                 795                 800 
Leu Ser Ser Val Glu Lys Met Glu Arg Trp Leu Cys Ser Lys Glu Asp
                805                 810                 815     
Ser Leu Ala Ser Glu Gly Leu Trp Asp Pro Leu Ala Pro Met Glu Pro
            820                 825                 830         
Leu Leu Trp Lys His Lys Met Leu Glu Trp Asp Leu Glu Val Gln Ala
        835                 840                 845             
Gly Lys Ile Ser Ala Leu Glu Ala Thr Ala Arg Gly Leu His Gln Gly
    850                 855                 860                 
Gly His Pro Glu Ala Gln Ser Ala Leu Gly Arg Cys Gln Ala Met Leu
865                 870                 875                 880 
Leu Arg Lys Glu Ala Leu Phe Arg Gln Ala Gly Thr Arg Arg His Arg
                885                 890                 895     
Leu Glu Glu Leu Arg Gln Leu Gln Ala Phe Leu Gln Asp Ser Gln Glu
            900                 905                 910         
Val Ala Ala Trp Leu Arg Glu Lys Asn Leu Val Ala Leu Glu Glu Gly
        915                 920                 925             
Leu Leu Asp Thr Ala Met Leu Pro Ala Gln Leu Gln Lys Gln Gln Asn
    930                 935                 940                 
Phe Gln Ala Glu Leu Asp Ala Ser Met His Gln Gln Gln Glu Leu Gln
945                 950                 955                 960 
Arg Glu Gly Gln Arg Leu Leu Gln Gly Gly His Pro Ala Ser Glu Ala
                965                 970                 975     
Ile Gln Glu Arg Leu Glu Glu Leu Gly Ala Leu Trp Gly Glu Leu Gln
            980                 985                 990         
Asp Asn Ser Gln Lys Lys Val Ala Lys Leu Gln Lys Ala Cys Glu Ala
        995                 1000                1005            
Leu Arg Leu Arg Arg Ser Met Glu Glu Leu Glu Asn Trp Leu Glu Pro
    1010                1015                1020                
Ile Glu Val Glu Leu Arg Ala Pro Thr Val Gly Gln Ala Leu Pro Gly
1025                1030                1035                1040
Val Gly Glu Leu Leu Gly Thr Gln Arg Glu Leu Glu Ala Ala Val Asp
                1045                1050                1055    
Lys Lys Ala Arg Gln Ala Glu Ala Leu Leu Gly Gln Ala Gln Ala Phe
            1060                1065                1070        
Val Arg Glu Gly His Cys Leu Ala Gln Asp Val Glu Glu Gln Ala Arg
        1075                1080                1085            
Arg Leu Leu Gln Arg Phe Lys Ser Leu Arg Glu Pro Leu Gln Glu Arg
    1090                1095                1100                
Arg Thr Ala Leu Glu Ala Arg Ser Leu Leu Leu Lys Phe Phe Arg Asp
1105                1110                1115                1120
Ala Asp Glu Glu Met Ala Trp Val Gln Glu Lys Leu Pro Leu Ala Ala
                1125                1130                1135    
Ala Gln Asp Tyr Gly Gln Ser Leu Ser Ala Val Arg His Leu Gln Glu
            1140                1145                1150        
Gln His Gln Asn Leu Glu Ser Glu Met Ser Ser His Glu Ala Leu Thr
        1155                1160                1165            
Arg Val Val Leu Gly Thr Gly Tyr Lys Leu Val Gln Ala Gly His Phe
    1170                1175                1180                
Ala Ala His Glu Val Ala Ala Arg Val Gln Gln Leu Glu Lys Ala Met
1185                1190                1195                1200
Ala His Leu Arg Ala Glu Ala Ala Arg Arg Arg Leu Leu Leu Gln Gln
                1205                1210                1215    
Ala Gln Glu Ala Gln Gln Phe Leu Thr Glu Leu Leu Glu Ala Gly Ser
            1220                1225                1230        
Trp Leu Ala Glu Arg Gly His Val Leu Asp Ser Glu Asp Met Gly His
        1235                1240                1245            
Ser Ala Glu Ala Thr Gln Ala Leu Leu Arg Arg Leu Glu Ala Thr Lys
    1250                1255                1260                
Arg Asp Leu Glu Ala Phe Ser Pro Arg Ile Glu Arg Leu Gln Gln Thr
1265                1270                1275                1280
Ala Ala Leu Leu Glu Ser Arg Lys Asn Pro Glu Ser Pro Lys Val Leu
                1285                1290                1295    
Ala Gln Leu Gln Ala Val Arg Glu Ala His Ala Glu Leu Leu Arg Arg
            1300                1305                1310        
Ala Glu Ala Arg Gly His Gly Leu Gln Glu Gln Leu Gln Leu His Gln
        1315                1320                1325            
Leu Glu Arg Glu Thr Leu Leu Leu Asp Ala Trp Leu Thr Thr Lys Ala
    1330                1335                1340                
Ala Thr Ala Glu Ser Gln Asp Tyr Gly Gln Asp Leu Glu Gly Val Lys
1345                1350                1355                1360
Val Leu Glu Glu Lys Phe Asp Ala Phe Arg Lys Glu Val Gln Ser Leu
                1365                1370                1375    
Gly Gln Ala Lys Val Tyr Ala Leu Arg Lys Leu Ala Gly Thr Leu Glu
            1380                1385                1390        
Arg Gly Ala Pro Arg Arg Tyr Pro His Ile Gln Ala Gln Arg Ser Arg
        1395                1400                1405            
Ile Glu Ala Ala Trp Glu Arg Leu Asp Gln Ala Ile Lys Ala Arg Thr
    1410                1415                1420                
Glu Asn Leu Ala Ala Ala His Glu Val His Ser Phe Gln Gln Ala Ala
1425                1430                1435                1440
Ala Glu Leu Gln Gly Arg Met Gln Glu Lys Thr Ala Leu Met Lys Gly
                1445                1450                1455    
Glu Asp Gly Gly His Ser Leu Ser Ser Val Arg Thr Leu Gln Gln Gln
            1460                1465                1470        
His Arg Arg Leu Glu Arg Glu Leu Glu Ala Met Glu Lys Glu Val Ala
        1475                1480                1485            
Arg Leu Gln Thr Glu Ala Cys Arg Leu Gly Gln Leu His Pro Ala Ala
    1490                1495                1500                
Pro Gly Gly Leu Ala Lys Val Gln Glu Ala Trp Ala Thr Leu Gln Ala
1505                1510                1515                1520
Lys Ala Gln Glu Arg Gly Gln Trp Leu Ala Gln Ala Ala Gln Gly His
                1525                1530                1535    
Ala Phe Leu Gly Arg Cys Gln Glu Leu Leu Ala Trp Ala Gln Glu Arg
            1540                1545                1550        
Gln Glu Leu Ala Ser Ser Glu Glu Leu Ala Glu Asp Val Ala Gly Ala
        1555                1560                1565            
Glu Gln Leu Leu Gly Gln His Glu Glu Leu Gly Gln Glu Ile Arg Glu
    1570                1575                1580                
Cys Arg Leu Gln Ala Gln Asp Leu Arg Gln Glu Gly Gln Gln Leu Val
1585                1590                1595                1600
Asp Asn Ser His Phe Met Ser Ala Glu Val Thr Glu Cys Leu Gln Glu
                1605                1610                1615    
Leu Glu Gly Arg Leu Gln Glu Leu Glu Glu Ala Trp Ala Leu Arg Trp
            1620                1625                1630        
Gln Arg Cys Ala Glu Ser Trp Gly Leu Gln Lys Leu Arg Gln Arg Leu
        1635                1640                1645            
Glu Gln Ala Glu Ala Trp Leu Ala Cys Trp Glu Gly Leu Leu Leu Lys
    1650                1655                1660                
Pro Asp Tyr Gly His Ser Val Ser Asp Val Glu Leu Leu Leu His Arg
1665                1670                1675                1680
His Gln Asp Leu Glu Lys Leu Leu Ala Ala Gln Glu Glu Lys Phe Ala
                1685                1690                1695    
Gln Met Gln Lys Thr Glu Met Glu Gln Glu Leu Leu Leu Gln Pro Gln
            1700                1705                1710        
Glu Leu Lys Pro Gly Arg Ala Gly Ser Ser Leu Thr Ser Phe Gln Trp
        1715                1720                1725            
Arg Pro Ser Gly His Gln Gly Leu Gly Ala Gln Leu Ala Glu Thr Arg
    1730                1735                1740                
Asp Pro Gln Asp Ala Lys Gly Thr Pro Thr Met Glu Gly Ser Leu Glu
1745                1750                1755                1760
Phe Lys Gln His Leu Leu Pro Gly Gly Arg Gln Pro Ser Ser Ser Ser
                1765                1770                1775    
Trp Asp Ser Cys Arg Gly Asn Leu Gln Gly Ser Ser Leu Ser Leu Phe
            1780                1785                1790        
Leu Asp Glu Arg Met Ala Ala Glu Lys Val Ala Ser Ile Ala Leu Leu
        1795                1800                1805            
Asp Leu Thr Gly Ala Arg Cys Glu Arg Leu Arg Gly Arg His Gly Arg
    1810                1815                1820                
Lys His Thr Phe Ser Leu Arg Leu Thr Ser Gly Ala Glu Ile Leu Phe
1825                1830                1835                1840
Ala Ala Pro Ser Glu Glu Gln Ala Glu Ser Trp Trp Arg Ala Leu Gly
                1845                1850                1855    
Ser Thr Ala Ala Gln Ser Leu Ser Pro Lys Leu Lys Ala Lys Pro Val
            1860                1865                1870        
Ser Ser Leu Asn Glu Cys Thr Thr Lys Asp Ala Arg Pro Gly Cys Leu
        1875                1880                1885            
Leu Arg Ser Asp Pro
    1890            


<210> 1697
<211> 112
<212> PRT
<213> Homo sapiens

<400> 1697
Met Asp Gly Glu Glu Lys Thr Tyr Gly Gly Cys Glu Gly Pro Asp Ala
 1               5                  10                  15      
Thr Tyr Val Lys Leu Ile Ser Ser Asp Gly His Glu Phe Ile Val Lys
            20                  25                  30          
Arg Glu His Ala Leu Thr Ser Gly Thr Ile Lys Ala Met Leu Ser Gly
        35                  40                  45              
Pro Gly Gln Phe Ala Glu Asn Glu Thr Asn Glu Val Asn Phe Arg Glu
    50                  55                  60                  
Ile Pro Ser His Val Leu Ser Lys Val Cys Met Tyr Phe Thr Tyr Lys
65                  70                  75                  80  
Val Arg Tyr Thr Asn Ser Ser Ile Glu Ile Pro Glu Phe Pro Ile Ala
                85                  90                  95      
Pro Glu Ile Val Leu Glu Leu Leu Met Ala Ala Asn Phe Leu Asp Cys
            100                 105                 110         


<210> 1698
<211> 206
<212> PRT
<213> Homo sapiens

<400> 1698
Met Pro Pro Trp Arg Glu Thr Leu Ala Ser Arg Val Ser Pro Arg Trp
 1               5                  10                  15      
Pro Leu Gly Glu Gly Gly Val Leu Ala Arg Ala Ala Val Ala Gln Arg
            20                  25                  30          
Pro Arg Glu Val Ser Leu Ser Ala Thr Asp Cys Tyr Ile Val His Glu
        35                  40                  45              
Ile Tyr Asn Gly Glu Asn Ala Gln Asp Gln Phe Glu Tyr Glu Leu Glu
    50                  55                  60                  
Gln Ala Leu Glu Ala Gln Tyr Lys Tyr Ile Val Ile Glu Pro Thr Arg
65                  70                  75                  80  
Ile Gly Asp Glu Thr Ala Arg Trp Ile Thr Val Gly Asn Cys Leu His
                85                  90                  95      
Lys Thr Ala Val Leu Ala Gly Thr Ala Cys Leu Phe Thr Pro Leu Ala
            100                 105                 110         
Leu Pro Leu Asp Tyr Ser His Tyr Ile Ser Leu Pro Ala Gly Val Leu
        115                 120                 125             
Ser Leu Ala Cys Cys Thr Leu Tyr Gly Ile Ser Trp Gln Phe Asp Pro
    130                 135                 140                 
Cys Cys Lys Tyr Gln Val Glu Tyr Asp Ala Tyr Lys Leu Ser Arg Leu
145                 150                 155                 160 
Pro Leu His Thr Leu Thr Ser Ser Thr Pro Val Val Leu Val Arg Lys
                165                 170                 175     
Asp Asp Leu His Arg Lys Arg Leu His Asn Thr Ile Ala Leu Ala Ala
            180                 185                 190         
Leu Val Tyr Cys Val Lys Lys Ile Tyr Glu Leu Tyr Ala Val
        195                 200                 205     


<210> 1699
<211> 136
<212> PRT
<213> Homo sapiens

<400> 1699
Met Pro Arg Pro Pro Arg Gly Tyr Pro Ala Cys Arg Ser Arg Ala Ala
 1               5                  10                  15      
Ala Pro Gly Trp Arg Trp Gly Arg Ala Glu Ala Ala Glu Val Leu Arg
            20                  25                  30          
Ala Thr Gly Gly Trp Gln Trp Ala Gly Glu Arg Gly Arg Gln Ala Arg
        35                  40                  45              
Leu Gly Leu Gly Leu Trp Arg Arg Gly Thr Leu Cys Leu Gly Ser Leu
    50                  55                  60                  
Thr Ala Pro Pro Gly Ser Pro Glu Arg Gly Thr Gly Gly Glu Gly Gly
65                  70                  75                  80  
Gly Ser Trp Ala Pro Cys Ala Ala Gly Pro Arg Gly Ala Arg Val Ala
                85                  90                  95      
Ala Gly Ser Ala Gly Pro Asp Arg Val Asn Gly Arg Ala Trp Pro Val
            100                 105                 110         
Pro Arg Gly Ala Pro Ala Ala Thr Ala Leu Ala Ala Gly Thr Gly Val
        115                 120                 125             
Leu Arg Gly Arg Ser Leu Pro Phe
    130                 135     


<210> 1700
<211> 1167
<212> PRT
<213> Homo sapiens

<400> 1700
Met Gly Ser Asp Ile Leu Ser Thr Gln Lys Ala Ala Val Glu Thr Ser
 1               5                  10                  15      
Phe Leu Asp Tyr Gly Glu Asn Leu Val Gln Lys Trp Gln Val Leu Ser
            20                  25                  30          
Glu Val Leu Ser Cys Ser Glu Lys Leu Val Cys His Leu Gly Arg Leu
        35                  40                  45              
Gly Ser Val Ser Glu Ala Lys Ala Phe Cys Leu Glu Ala Leu Lys Leu
    50                  55                  60                  
Thr Thr Lys Leu Gln Ile Pro Arg Gln Cys Ala Leu Phe Leu Val Leu
65                  70                  75                  80  
Lys Gly Glu Leu Glu Leu Ala Arg Asn Asp Ile Asp Leu Cys Gln Ser
                85                  90                  95      
Asp Leu Gln Gln Val Leu Phe Leu Leu Glu Ser Cys Thr Glu Phe Gly
            100                 105                 110         
Gly Val Thr Gln His Leu Asp Ser Val Lys Lys Val His Leu Gln Lys
        115                 120                 125             
Gly Lys Gln Gln Ala Gln Val Pro Cys Pro Pro Gln Leu Pro Glu Glu
    130                 135                 140                 
Glu Leu Phe Leu Arg Gly Pro Ala Leu Glu Leu Val Ala Thr Val Ala
145                 150                 155                 160 
Lys Glu Pro Gly Pro Ile Ala Pro Ser Thr Asn Ser Ser Pro Val Leu
                165                 170                 175     
Lys Thr Lys Pro Gln Pro Ile Pro Asn Phe Leu Ser His Ser Pro Thr
            180                 185                 190         
Cys Asp Cys Ser Leu Cys Ala Ser Pro Val Leu Thr Ala Val Cys Leu
        195                 200                 205             
Arg Trp Val Leu Val Thr Ala Gly Val Arg Leu Ala Met Gly His Gln
    210                 215                 220                 
Ala Gln Gly Leu Asp Leu Leu Gln Val Val Leu Lys Gly Cys Pro Glu
225                 230                 235                 240 
Ala Ala Glu Arg Leu Thr Gln Ala Leu Gln Ala Ser Leu Asn His Lys
                245                 250                 255     
Thr Pro Pro Ser Leu Val Pro Ser Leu Leu Asp Glu Ile Leu Ala Gln
            260                 265                 270         
Ala Tyr Thr Leu Leu Ala Leu Glu Gly Leu Asn Gln Pro Ser Asn Glu
        275                 280                 285             
Ser Leu Gln Lys Val Leu Gln Ser Gly Leu Lys Phe Val Ala Ala Arg
    290                 295                 300                 
Ile Pro His Leu Glu Pro Trp Arg Ala Ser Leu Leu Leu Ile Trp Ala
305                 310                 315                 320 
Leu Thr Lys Leu Gly Gly Leu Ser Cys Cys Thr Thr Gln Leu Phe Ala
                325                 330                 335     
Ser Ser Trp Gly Trp Gln Pro Pro Leu Ile Lys Ser Val Pro Gly Ser
            340                 345                 350         
Glu Pro Ser Lys Thr Gln Gly Gln Lys Arg Ser Gly Arg Gly Arg Gln
        355                 360                 365             
Lys Leu Ala Ser Ala Pro Leu Arg Leu Asn Asn Thr Ser Gln Lys Gly
    370                 375                 380                 
Leu Glu Gly Arg Gly Leu Pro Cys Thr Pro Lys Pro Pro Asp Arg Ile
385                 390                 395                 400 
Arg Gln Ala Gly Pro His Val Pro Phe Thr Val Phe Glu Glu Val Cys
                405                 410                 415     
Pro Thr Glu Ser Lys Pro Glu Val Pro Gln Ala Pro Arg Val Gln Gln
            420                 425                 430         
Arg Val Gln Thr Arg Leu Lys Val Asn Phe Ser Asp Asp Ser Asp Leu
        435                 440                 445             
Glu Asp Pro Val Ser Ala Glu Ala Trp Leu Ala Glu Glu Pro Lys Arg
    450                 455                 460                 
Arg Gly Thr Ala Ser Arg Gly Arg Gly Arg Ala Arg Lys Gly Leu Ser
465                 470                 475                 480 
Leu Lys Thr Asp Ala Val Val Ala Pro Gly Ser Ala Pro Gly Asn Pro
                485                 490                 495     
Gly Leu Asn Gly Arg Ser Arg Arg Ala Lys Lys Val Ala Ser Arg His
            500                 505                 510         
Cys Glu Glu Arg Arg Pro Gln Arg Ala Ser Asp Gln Ala Arg Pro Gly
        515                 520                 525             
Pro Glu Ile Met Arg Thr Ile Pro Glu Glu Glu Leu Thr Asp Asn Trp
    530                 535                 540                 
Arg Lys Met Ser Phe Glu Ile Leu Arg Gly Ser Asp Gly Glu Asp Ser
545                 550                 555                 560 
Ala Ser Gly Gly Lys Thr Pro Ala Pro Gly Pro Glu Ala Ala Ser Gly
                565                 570                 575     
Glu Trp Glu Leu Leu Arg Leu Asp Ser Ser Lys Lys Lys Leu Pro Ser
            580                 585                 590         
Pro Cys Pro Asp Lys Glu Ser Asp Lys Asp Leu Gly Pro Arg Leu Arg
        595                 600                 605             
Leu Pro Ser Ala Pro Val Ala Thr Gly Leu Ser Thr Leu Asp Ser Ile
    610                 615                 620                 
Cys Asp Ser Leu Ser Val Ala Phe Arg Gly Ile Ser His Cys Pro Pro
625                 630                 635                 640 
Ser Gly Leu Tyr Ala His Leu Cys Arg Phe Leu Ala Leu Cys Leu Gly
                645                 650                 655     
His Arg Asp Pro Tyr Ala Thr Ala Phe Leu Val Thr Glu Ser Val Ser
            660                 665                 670         
Ile Thr Cys Arg His Gln Leu Leu Thr His Leu His Arg Gln Leu Ser
        675                 680                 685             
Lys Ala Gln Lys His Arg Gly Ser Leu Glu Ile Ala Asp Gln Leu Gln
    690                 695                 700                 
Gly Leu Ser Leu Gln Glu Met Pro Gly Asp Val Pro Leu Ala Arg Ile
705                 710                 715                 720 
Gln Arg Leu Phe Ser Phe Arg Ala Leu Glu Ser Gly His Phe Pro Gln
                725                 730                 735     
Pro Glu Lys Glu Ser Phe Gln Glu Arg Leu Ala Leu Ile Pro Ser Gly
            740                 745                 750         
Val Thr Val Cys Val Leu Ala Leu Ala Thr Leu Gln Pro Gly Thr Val
        755                 760                 765             
Gly Asn Thr Leu Leu Leu Thr Arg Leu Glu Lys Asp Ser Pro Pro Val
    770                 775                 780                 
Ser Val Gln Ile Pro Thr Gly Gln Asn Lys Leu His Leu Arg Ser Val
785                 790                 795                 800 
Leu Asn Glu Phe Asp Ala Ile Gln Lys Ala Gln Lys Glu Asn Ser Ser
                805                 810                 815     
Cys Thr Asp Lys Arg Glu Trp Trp Thr Gly Arg Leu Ala Leu Asp His
            820                 825                 830         
Arg Met Glu Val Leu Ile Ala Ser Leu Glu Lys Ser Val Leu Gly Cys
        835                 840                 845             
Trp Lys Gly Leu Leu Leu Pro Ser Ser Glu Glu Pro Gly Pro Ala Gln
    850                 855                 860                 
Glu Ala Ser Arg Leu Gln Glu Leu Leu Gln Asp Cys Gly Trp Lys Tyr
865                 870                 875                 880 
Pro Asp Arg Thr Leu Leu Lys Ile Met Leu Ser Gly Ala Gly Ala Leu
                885                 890                 895     
Thr Pro Gln Asp Ile Gln Ala Leu Ala Tyr Gly Leu Cys Pro Thr Gln
            900                 905                 910         
Pro Glu Arg Ala Gln Glu Leu Leu Asn Glu Ala Val Gly Arg Leu Gln
        915                 920                 925             
Gly Leu Thr Val Pro Ser Asn Ser His Leu Val Leu Val Leu Asp Lys
    930                 935                 940                 
Asp Leu Gln Lys Leu Pro Trp Glu Ser Met Pro Ser Leu Gln Ala Leu
945                 950                 955                 960 
Pro Val Thr Arg Leu Pro Ser Phe Arg Phe Leu Leu Ser Tyr Ser Ile
                965                 970                 975     
Ile Lys Glu Tyr Gly Ala Ser Pro Val Leu Ser Gln Gly Val Asp Pro
            980                 985                 990         
Arg Ser Thr Phe Tyr Val Leu Asn Pro His Asn Asn Leu Ser Ser Thr
        995                 1000                1005            
Glu Glu Gln Phe Arg Ala Asn Phe Ser Ser Glu Ala Gly Trp Arg Gly
    1010                1015                1020                
Val Val Gly Glu Val Pro Arg Pro Glu Gln Val Gln Glu Ala Leu Thr
1025                1030                1035                1040
Lys His Asp Leu Tyr Ile Tyr Ala Gly His Gly Ala Gly Ala Arg Phe
                1045                1050                1055    
Leu Asp Gly Gln Ala Val Leu Arg Leu Ser Cys Arg Ala Val Ala Leu
            1060                1065                1070        
Leu Phe Gly Cys Ser Ser Ala Ala Leu Ala Val Arg Gly Asn Leu Glu
        1075                1080                1085            
Gly Ala Gly Ile Val Leu Lys Tyr Ile Met Ala Gly Cys Pro Leu Phe
    1090                1095                1100                
Leu Gly Asn Leu Trp Asp Val Thr Asp Arg Asp Ile Asp Arg Tyr Thr
1105                1110                1115                1120
Glu Ala Leu Leu Gln Gly Trp Leu Gly Ala Gly Pro Gly Ala Pro Leu
                1125                1130                1135    
Leu Tyr Tyr Val Asn Gln Ala Arg Gln Ala Pro Arg Leu Lys Tyr Leu
            1140                1145                1150        
Ile Gly Ala Ala Pro Ile Ala Tyr Gly Leu Pro Val Ser Leu Arg
        1155                1160                1165        


<210> 1701
<211> 448
<212> PRT
<213> Homo sapiens

<400> 1701
Met Ile Pro Thr Phe Thr Ala Leu Leu Cys Leu Gly Leu Ser Leu Gly
 1               5                  10                  15      
Pro Arg Thr His Met Gln Ala Gly Pro Leu Pro Lys Pro Thr Leu Trp
            20                  25                  30          
Ala Glu Pro Gly Ser Val Ile Ser Trp Gly Asn Ser Val Thr Ile Trp
        35                  40                  45              
Cys Gln Gly Thr Leu Glu Ala Arg Glu Tyr Arg Leu Asp Lys Glu Glu
    50                  55                  60                  
Ser Pro Ala Pro Trp Asp Arg Gln Asn Pro Leu Glu Pro Lys Asn Lys
65                  70                  75                  80  
Ala Arg Phe Ser Ile Pro Ser Met Thr Glu Asp Tyr Ala Gly Arg Tyr
                85                  90                  95      
Arg Cys Tyr Tyr Arg Ser Pro Val Gly Trp Ser Gln Pro Ser Asp Pro
            100                 105                 110         
Leu Glu Leu Val Met Thr Gly Ala Tyr Ser Lys Pro Thr Leu Ser Ala
        115                 120                 125             
Leu Pro Ser Pro Leu Val Thr Ser Gly Lys Ser Val Thr Leu Leu Cys
    130                 135                 140                 
Gln Ser Arg Ser Pro Met Asp Thr Phe Leu Leu Ile Lys Glu Arg Ala
145                 150                 155                 160 
Ala His Pro Leu Leu His Leu Arg Ser Glu His Gly Ala Gln Gln His
                165                 170                 175     
Gln Ala Glu Phe Pro Met Ser Pro Val Thr Ser Val His Gly Gly Thr
            180                 185                 190         
Tyr Arg Cys Phe Ser Ser His Gly Phe Ser His Tyr Leu Leu Ser His
        195                 200                 205             
Pro Ser Asp Pro Leu Glu Leu Ile Val Ser Gly Ser Leu Glu Asp Pro
    210                 215                 220                 
Arg Pro Ser Pro Thr Arg Ser Val Ser Thr Ala Ala Gly Pro Glu Asp
225                 230                 235                 240 
Gln Pro Leu Met Pro Thr Gly Ser Val Pro His Ser Gly Leu Arg Arg
                245                 250                 255     
His Trp Glu Val Leu Ile Gly Val Leu Val Val Ser Ile Leu Leu Leu
            260                 265                 270         
Ser Leu Leu Leu Phe Leu Leu Leu Gln His Trp Arg Gln Gly Lys His
        275                 280                 285             
Arg Thr Leu Ala Gln Arg Gln Ala Asp Phe Gln Arg Pro Pro Gly Ala
    290                 295                 300                 
Ala Glu Pro Glu Pro Lys Asp Gly Gly Leu Gln Arg Arg Ser Ser Pro
305                 310                 315                 320 
Ala Ala Asp Val Gln Gly Glu Asn Phe Cys Ala Ala Val Lys Asn Thr
                325                 330                 335     
Gln Pro Glu Asp Gly Val Glu Met Asp Thr Arg Gln Ser Pro His Asp
            340                 345                 350         
Glu Asp Pro Gln Ala Val Thr Tyr Ala Lys Val Lys His Ser Arg Pro
        355                 360                 365             
Arg Arg Glu Met Ala Ser Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu
    370                 375                 380                 
Asp Thr Lys Asp Arg Gln Ala Glu Glu Asp Arg Gln Met Asp Thr Glu
385                 390                 395                 400 
Ala Ala Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu His
                405                 410                 415     
Ser Phe Thr Leu Arg Gln Lys Ala Thr Glu Pro Pro Pro Ser Gln Glu
            420                 425                 430         
Gly Ala Ser Pro Ala Glu Pro Ser Val Tyr Ala Thr Leu Ala Ile His
        435                 440                 445             


<210> 1702
<211> 409
<212> PRT
<213> Homo sapiens

<400> 1702
Met Ser Gly Arg Ser Val Arg Leu Arg Ser Val Pro Ile Gln Ser Leu
 1               5                  10                  15      
Ser Glu Leu Glu Arg Ala Arg Leu Gln Glu Val Ala Phe Tyr Gln Leu
            20                  25                  30          
Gln Gln Asp Cys Asp Leu Ser Cys Gln Ile Thr Ile Pro Lys Asp Gly
        35                  40                  45              
Gln Lys Arg Lys Lys Ser Leu Arg Lys Lys Leu Asp Ser Leu Gly Lys
    50                  55                  60                  
Glu Lys Asn Lys Asp Lys Glu Phe Ile Pro Gln Ala Phe Gly Met Pro
65                  70                  75                  80  
Leu Ser Gln Val Ile Ala Asn Asp Arg Ala Tyr Lys Leu Lys Gln Asp
                85                  90                  95      
Leu Gln Arg Asp Glu Gln Lys Asp Ala Ser Asp Phe Val Ala Ser Leu
            100                 105                 110         
Leu Pro Phe Gly Asn Lys Arg Gln Asn Lys Glu Leu Ser Ser Ser Asn
        115                 120                 125             
Ser Ser Leu Ser Ser Thr Ser Glu Thr Pro Asn Glu Ser Thr Ser Pro
    130                 135                 140                 
Asn Thr Pro Glu Pro Ala Pro Arg Ala Arg Arg Arg Gly Ala Met Ser
145                 150                 155                 160 
Val Asp Ser Ile Thr Asp Leu Asp Asp Asn Gln Ser Arg Leu Leu Glu
                165                 170                 175     
Ala Leu Gln Leu Ser Leu Pro Ala Glu Ala Gln Ser Lys Lys Glu Lys
            180                 185                 190         
Ala Arg Asp Lys Lys Leu Ser Leu Asn Pro Ile Tyr Arg Gln Val Pro
        195                 200                 205             
Arg Leu Val Asp Ser Cys Cys Gln His Leu Glu Lys His Gly Leu Gln
    210                 215                 220                 
Thr Val Gly Ile Phe Arg Val Gly Ser Ser Lys Lys Arg Val Arg Gln
225                 230                 235                 240 
Leu Arg Glu Glu Phe Asp Arg Gly Ile Asp Val Ser Leu Glu Glu Glu
                245                 250                 255     
His Ser Val His Asp Val Ala Ala Leu Leu Lys Glu Phe Leu Arg Asp
            260                 265                 270         
Met Pro Asp Pro Leu Leu Thr Arg Glu Leu Tyr Thr Ala Phe Ile Asn
        275                 280                 285             
Thr Leu Leu Leu Glu Pro Glu Glu Gln Leu Gly Thr Leu Gln Leu Leu
    290                 295                 300                 
Ile Tyr Leu Leu Pro Pro Cys Asn Cys Asp Thr Leu His Arg Leu Leu
305                 310                 315                 320 
Gln Phe Leu Ser Ile Val Ala Arg His Ala Asp Asp Asn Ile Ser Lys
                325                 330                 335     
Asp Gly Gln Glu Val Thr Gly Asn Lys Met Thr Ser Leu Asn Leu Ala
            340                 345                 350         
Thr Ile Phe Gly Pro Asn Leu Leu His Lys Gln Lys Ser Ser Asp Lys
        355                 360                 365             
Glu Phe Ser Val Gln Ser Ser Ala Arg Ala Glu Glu Ser Thr Ala Ile
    370                 375                 380                 
Ile Ala Val Val Gln Lys Met Ile Glu Asn Tyr Glu Ala Leu Phe Met
385                 390                 395                 400 
Phe Pro Gln Ile Ser Arg Thr Lys Cys
                405                 


<210> 1703
<211> 1189
<212> PRT
<213> Homo sapiens

<400> 1703
Met Asp Arg Asn Pro Asn Asn Asp Gln Val Phe Pro Asn Gly Thr Leu
 1               5                  10                  15      
Ala Pro Ser Ile Pro Ile Trp Gly Gly Ser Trp Arg Ala Pro Gly Trp
            20                  25                  30          
Asp Pro Leu Cys Trp Asp Glu Cys Arg Gly Ser Cys Pro Thr Cys Pro
        35                  40                  45              
Glu Asp Arg Leu Glu Gln Tyr Glu Gly Pro Gly Phe Cys Gly Pro Leu
    50                  55                  60                  
Ser Ser Gly Thr Gly Gly Pro Phe Thr Thr Cys His Ala His Val Pro
65                  70                  75                  80  
Pro Glu Ser Phe Phe Lys Gly Cys Val Leu Asp Val Cys Met Gly Gly
                85                  90                  95      
Gly Asp Arg Asp Ile Leu Cys Lys Ala Leu Ala Ser Tyr Val Ala Ala
            100                 105                 110         
Cys Gln Ala Ala Gly Val Val Ile Glu Asp Trp Arg Ala Gln Val Gly
        115                 120                 125             
Cys Glu Ile Thr Cys Pro Glu Asn Ser His Tyr Glu Val Cys Gly Pro
    130                 135                 140                 
Pro Cys Pro Ala Ser Cys Pro Ser Pro Ala Pro Leu Thr Thr Pro Ala
145                 150                 155                 160 
Val Cys Glu Gly Pro Cys Val Glu Gly Cys Gln Cys Asp Ala Gly Phe
                165                 170                 175     
Val Leu Ser Ala Asp Arg Cys Val Pro Leu Asn Asn Gly Cys Gly Cys
            180                 185                 190         
Trp Ala Asn Gly Thr Tyr His Glu Ala Gly Ser Glu Phe Trp Ala Asp
        195                 200                 205             
Gly Thr Cys Ser Gln Trp Cys Arg Cys Gly Pro Gly Gly Gly Ser Leu
    210                 215                 220                 
Val Cys Thr Pro Ala Ser Cys Gly Leu Gly Glu Val Cys Gly Leu Leu
225                 230                 235                 240 
Pro Ser Gly Gln His Gly Cys Gln Pro Val Ser Thr Ala Glu Cys Gln
                245                 250                 255     
Ala Trp Gly Asp Pro His Tyr Val Thr Leu Asp Gly His Arg Phe Asp
            260                 265                 270         
Phe Gln Gly Thr Cys Glu Tyr Leu Leu Ser Ala Pro Cys His Gly Pro
        275                 280                 285             
Pro Leu Gly Ala Glu Asn Phe Thr Val Thr Val Ala Asn Glu His Arg
    290                 295                 300                 
Gly Ser Gln Ala Val Ser Tyr Thr Arg Ser Val Thr Leu Gln Ile Tyr
305                 310                 315                 320 
Asn His Ser Leu Thr Leu Ser Ala Arg Trp Pro Arg Lys Leu Gln Val
                325                 330                 335     
Asp Gly Val Phe Val Ala Leu Pro Phe Gln Leu Asp Ser Leu Leu His
            340                 345                 350         
Ala His Leu Ser Gly Ala Asp Val Val Val Thr Thr Thr Ser Gly Leu
        355                 360                 365             
Ser Leu Ala Phe Asp Gly Asp Ser Phe Val Arg Leu Arg Val Pro Ala
    370                 375                 380                 
Ala Tyr Ala Ala Ser Leu Cys Gly Leu Cys Gly Asn Tyr Asn Gln Asp
385                 390                 395                 400 
Pro Ala Asp Asp Leu Lys Ala Val Gly Gly Lys Pro Ala Gly Trp Gln
                405                 410                 415     
Val Gly Gly Ala Gln Gly Cys Gly Glu Cys Val Ser Lys Pro Cys Pro
            420                 425                 430         
Ser Pro Cys Thr Pro Glu Gln Gln Glu Ser Phe Gly Gly Pro Asp Ala
        435                 440                 445             
Cys Gly Val Ile Ser Ala Ile Ser Ala Thr Asp Gly Pro Leu Ala Pro
    450                 455                 460                 
Cys His Gly Leu Val Pro Pro Ala Gln Tyr Phe Gln Gly Cys Leu Leu
465                 470                 475                 480 
Asp Ala Cys Gln Val Gln Gly His Pro Gly Gly Leu Cys Pro Ala Val
                485                 490                 495     
Ala Thr Tyr Val Ala Ala Cys Gln Ala Ala Gly Ala Gln Leu Gly Glu
            500                 505                 510         
Trp Arg Arg Pro Asp Phe Cys Pro Leu Gln Cys Pro Ala His Ser His
        515                 520                 525             
Tyr Glu Leu Cys Gly Asp Ser Cys Pro Val Ser Cys Pro Ser Leu Ser
    530                 535                 540                 
Ala Pro Glu Gly Cys Glu Ser Ala Cys Arg Glu Gly Cys Val Cys Asp
545                 550                 555                 560 
Ala Gly Phe Val Leu Ser Gly Asp Thr Cys Val Pro Val Gly Gln Cys
                565                 570                 575     
Gly Cys Leu His Asp Gly Arg Tyr Tyr Pro Leu Gly Glu Val Phe Tyr
            580                 585                 590         
Pro Gly Pro Glu Cys Glu Arg Arg Cys Glu Cys Gly Pro Gly Gly His
        595                 600                 605             
Val Thr Cys Gln Glu Gly Ala Ala Cys Gly Pro His Glu Glu Cys Arg
    610                 615                 620                 
Leu Glu Asp Gly Val Gln Ala Cys His Ala Thr Gly Cys Gly Arg Cys
625                 630                 635                 640 
Leu Ala Asn Gly Gly Ile His Tyr Ile Thr Leu Asp Gly Arg Val Tyr
                645                 650                 655     
Asp Leu His Gly Ser Cys Ser Tyr Val Leu Ala Gln Val Cys His Pro
            660                 665                 670         
Lys Pro Gly Asp Glu Asp Phe Ser Ile Val Leu Glu Lys Asn Ala Ala
        675                 680                 685             
Gly Asp Leu Gln Arg Leu Leu Val Thr Val Ala Gly Gln Val Val Ser
    690                 695                 700                 
Leu Ala Gln Gly Gln Gln Val Thr Val Asp Gly Glu Ala Val Ala Leu
705                 710                 715                 720 
Pro Val Ala Val Gly Arg Val Arg Val Thr Ala Glu Gly Arg Asn Met
                725                 730                 735     
Val Leu Gln Thr Thr Lys Gly Leu Arg Leu Leu Phe Asp Gly Asp Ala
            740                 745                 750         
His Leu Leu Met Ser Ile Pro Ser Pro Phe Arg Gly Arg Leu Cys Gly
        755                 760                 765             
Leu Cys Gly Asn Phe Asn Gly Asn Trp Ser Asp Asp Phe Val Leu Pro
    770                 775                 780                 
Asn Gly Ser Ala Ala Ser Ser Val Glu Thr Phe Gly Ala Ala Trp Arg
785                 790                 795                 800 
Ala Pro Gly Ser Ser Lys Gly Cys Gly Glu Gly Cys Gly Pro Gln Gly
                805                 810                 815     
Cys Pro Val Cys Leu Ala Glu Glu Thr Ala Pro Tyr Glu Ser Asn Glu
            820                 825                 830         
Ala Cys Gly Gln Leu Arg Asn Pro Gln Gly Pro Phe Ala Thr Cys Gln
        835                 840                 845             
Ala Val Leu Ser Pro Ser Glu Tyr Phe Arg Gln Cys Val Tyr Asp Leu
    850                 855                 860                 
Cys Ala Gln Lys Gly Asp Lys Ala Phe Leu Cys Arg Ser Leu Ala Ala
865                 870                 875                 880 
Tyr Thr Ala Ala Cys Gln Ala Ala Gly Val Ala Val Lys Pro Trp Arg
                885                 890                 895     
Thr Asp Ser Phe Cys Pro Leu His Cys Pro Ala His Ser His Tyr Ser
            900                 905                 910         
Ile Cys Thr Arg Thr Cys Gln Gly Ser Cys Ala Ala Leu Ser Gly Leu
        915                 920                 925             
Thr Gly Cys Thr Thr Arg Cys Phe Glu Gly Cys Glu Cys Asp Asp Arg
    930                 935                 940                 
Phe Leu Leu Ser Gln Gly Val Cys Ile Pro Val Gln Asp Cys Gly Cys
945                 950                 955                 960 
Thr His Asn Gly Arg Tyr Leu Pro Val Asn Ser Ser Leu Leu Thr Ser
                965                 970                 975     
Asp Cys Ser Glu Arg Cys Ser Cys Ser Ser Ser Ser Gly Leu Thr Cys
            980                 985                 990         
Gln Ala Ala Gly Cys Pro Pro Gly Arg Val Cys Glu Val Lys Ala Glu
        995                 1000                1005            
Ala Arg Asn Cys Trp Ala Thr Arg Gly Leu Cys Val Leu Ser Val Gly
    1010                1015                1020                
Ala Asn Leu Thr Thr Phe Asp Gly Ala Arg Gly Ala Thr Thr Ser Pro
1025                1030                1035                1040
Gly Val Tyr Glu Leu Ser Ser Arg Cys Pro Gly Leu Gln Asn Thr Ile
                1045                1050                1055    
Pro Trp Tyr Arg Val Val Ala Glu Val Gln Ile Cys His Gly Lys Thr
            1060                1065                1070        
Glu Ala Val Gly Gln Val His Ile Phe Phe Gln Asp Gly Met Val Thr
        1075                1080                1085            
Leu Thr Pro Asn Lys Gly Val Trp Val Asn Gly Leu Arg Val Asp Leu
    1090                1095                1100                
Pro Ala Glu Lys Leu Ala Ser Val Ser Val Ser Arg Thr Pro Asp Gly
1105                1110                1115                1120
Ser Leu Leu Val Arg Gln Lys Ala Gly Val Gln Val Trp Leu Gly Ala
                1125                1130                1135    
Asn Gly Lys Val Ala Val Ile Val Ser Asn Asp His Ala Gly Lys Leu
            1140                1145                1150        
Cys Gly Ala Cys Gly Asn Phe Asp Gly Asp Gln Thr Asn Asp Trp His
        1155                1160                1165            
Asp Ser Gln Glu Lys Pro Ala Met Glu Lys Trp Arg Ala Gln Asp Phe
    1170                1175                1180                
Ser Pro Cys Tyr Gly
1185                


<210> 1704
<211> 846
<212> PRT
<213> Homo sapiens

<400> 1704
Met Lys Lys Phe Thr Gln Val Leu Glu Asp Asp Glu Lys Ile Arg Lys
 1               5                  10                  15      
Gln Leu Glu Val Leu Val Ser Pro Thr Cys Ser Cys Lys Gln Ala Glu
            20                  25                  30          
Gly Cys Val Arg Glu Ile Thr Lys Lys Leu Gly Asn Pro Lys Gln Pro
        35                  40                  45              
Thr Asn Pro Phe Leu Glu Met Ile Lys Phe Leu Leu Glu Arg Ile Ala
    50                  55                  60                  
Pro Val His Ile Asp Thr Glu Ser Ile Ser Ala Leu Ile Lys Gln Val
65                  70                  75                  80  
Asn Lys Ser Ile Asp Gly Thr Ala Asp Asp Glu Asp Glu Gly Val Pro
                85                  90                  95      
Thr Asp Gln Ala Ile Arg Ala Gly Leu Glu Leu Leu Lys Val Leu Ser
            100                 105                 110         
Phe Thr His Pro Ile Ser Phe His Ser Ala Glu Thr Phe Glu Ser Leu
        115                 120                 125             
Leu Ala Cys Leu Lys Met Asp Asp Glu Lys Val Ala Glu Ala Ala Leu
    130                 135                 140                 
Gln Ile Phe Lys Asn Thr Gly Ser Lys Ile Glu Glu Asp Phe Pro His
145                 150                 155                 160 
Ile Arg Ser Ala Leu Leu Pro Val Leu His His Lys Ser Lys Lys Gly
                165                 170                 175     
Pro Pro Arg Gln Ala Lys Tyr Ala Ile His Cys Ile His Ala Ile Phe
            180                 185                 190         
Ser Ser Lys Glu Thr Gln Phe Ala Gln Ile Phe Glu Pro Leu His Lys
        195                 200                 205             
Ser Leu Asp Pro Ser Asn Leu Glu His Leu Ile Thr Pro Leu Val Thr
    210                 215                 220                 
Ile Gly His Ile Ala Leu Leu Ala Pro Asp Gln Phe Ala Ala Pro Leu
225                 230                 235                 240 
Lys Ser Leu Val Ala Thr Phe Ile Val Lys Asp Leu Leu Met Asn Asp
                245                 250                 255     
Arg Leu Pro Gly Lys Lys Thr Thr Lys Leu Trp Val Pro Asp Glu Glu
            260                 265                 270         
Val Ser Pro Glu Thr Met Val Lys Ile Gln Ala Ile Lys Met Met Val
        275                 280                 285             
Arg Trp Leu Leu Gly Met Lys Asn Asn His Ser Lys Ser Gly Thr Ser
    290                 295                 300                 
Thr Leu Arg Leu Leu Thr Thr Ile Leu His Ser Asp Gly Asp Leu Thr
305                 310                 315                 320 
Glu Gln Gly Lys Ile Ser Lys Pro Asp Met Ser Arg Leu Arg Leu Ala
                325                 330                 335     
Ala Gly Ser Ala Ile Val Lys Leu Ala Gln Glu Pro Cys Tyr His Glu
            340                 345                 350         
Ile Ile Thr Leu Glu Gln Tyr Gln Leu Cys Ala Leu Ala Ile Asn Asp
        355                 360                 365             
Glu Cys Tyr Gln Val Arg Gln Val Phe Ala Gln Lys Leu His Lys Gly
    370                 375                 380                 
Leu Ser Arg Leu Arg Leu Pro Leu Glu Tyr Met Ala Ile Cys Ala Leu
385                 390                 395                 400 
Cys Ala Lys Asp Pro Val Lys Glu Arg Arg Ala His Ala Arg Gln Cys
                405                 410                 415     
Leu Val Lys Asn Ile Asn Val Arg Arg Glu Tyr Leu Lys Gln His Ala
            420                 425                 430         
Ala Val Ser Glu Lys Leu Leu Ser Leu Leu Pro Glu Tyr Val Val Pro
        435                 440                 445             
Tyr Thr Ile His Leu Leu Ala His Asp Pro Asp Tyr Val Lys Val Gln
    450                 455                 460                 
Asp Ile Glu Gln Leu Lys Asp Val Lys Glu Cys Leu Trp Phe Val Leu
465                 470                 475                 480 
Glu Ile Leu Met Ala Lys Asn Glu Asn Asn Ser His Ala Phe Ile Arg
                485                 490                 495     
Lys Met Val Glu Asn Ile Lys Gln Thr Lys Asp Ala Gln Gly Pro Asp
            500                 505                 510         
Asp Ala Lys Met Asn Glu Lys Leu Tyr Thr Val Cys Asp Val Ala Met
        515                 520                 525             
Asn Ile Ile Met Ser Lys Ser Thr Thr Tyr Ser Leu Glu Ser Pro Lys
    530                 535                 540                 
Asp Pro Val Leu Pro Ala Arg Phe Phe Thr Gln Pro Asp Lys Asn Phe
545                 550                 555                 560 
Ser Asn Thr Lys Asn Tyr Leu Pro Pro Glu Met Lys Ser Phe Phe Thr
                565                 570                 575     
Pro Gly Lys Pro Lys Thr Thr Asn Val Leu Gly Ala Val Asn Lys Pro
            580                 585                 590         
Leu Ser Ser Ala Gly Lys Gln Ser Gln Thr Lys Ser Ser Arg Met Glu
        595                 600                 605             
Thr Val Ser Asn Ala Ser Ser Ser Ser Asn Pro Ser Ser Pro Gly Arg
    610                 615                 620                 
Ile Lys Gly Arg Leu Asp Ser Ser Glu Met Asp His Ser Glu Asn Glu
625                 630                 635                 640 
Asp Tyr Thr Met Ser Ser Pro Leu Pro Gly Lys Lys Ser Asp Lys Arg
                645                 650                 655     
Asp Asp Ser Asp Leu Val Arg Ser Glu Leu Glu Lys Pro Arg Gly Arg
            660                 665                 670         
Lys Lys Thr Pro Val Thr Glu Gln Glu Glu Lys Leu Gly Met Asp Asp
        675                 680                 685             
Leu Thr Lys Leu Val Gln Glu Gln Lys Pro Lys Gly Ser Gln Arg Ser
    690                 695                 700                 
Arg Lys Arg Gly His Thr Ala Ser Glu Ser Asp Glu Gln Gln Trp Pro
705                 710                 715                 720 
Glu Glu Lys Arg Leu Lys Glu Asp Ile Leu Glu Asn Glu Asp Glu Gln
                725                 730                 735     
Asn Ser Pro Pro Lys Lys Gly Lys Arg Gly Arg Pro Pro Lys Pro Leu
            740                 745                 750         
Gly Gly Gly Thr Pro Lys Glu Glu Pro Thr Met Lys Thr Ser Lys Lys
        755                 760                 765             
Gly Ser Lys Lys Lys Ser Gly Pro Pro Ala Pro Glu Glu Glu Glu Glu
    770                 775                 780                 
Glu Glu Arg Gln Ser Gly Asn Thr Glu Gln Lys Ser Lys Ser Lys Gln
785                 790                 795                 800 
His Arg Val Ser Arg Arg Ala Gln Gln Arg Ala Glu Ser Pro Glu Ser
                805                 810                 815     
Ser Ala Ile Glu Ser Thr Gln Ser Thr Pro Gln Lys Gly Arg Gly Arg
            820                 825                 830         
Pro Ser Lys Thr Pro Ser Pro Ser Gln Pro Lys Lys Asn Val
        835                 840                 845     


<210> 1705
<211> 693
<212> PRT
<213> Homo sapiens

<400> 1705
Met Trp Pro Gln Pro Tyr Leu Pro Pro His Pro Met Met Leu Glu Glu
 1               5                  10                  15      
Ser Arg Gln Asn Lys Leu Ala Ala Ala Lys Lys Lys Leu Lys Glu Tyr
            20                  25                  30          
Gln Gln Arg Lys Ser Pro Gly Ile Pro Ala Gly Ala Lys Thr Lys Lys
        35                  40                  45              
Lys Lys Thr Asp Ser Ser Pro Glu Thr Thr Thr Ser Gly Gly Gly His
    50                  55                  60                  
Ser Pro Gly Asp Ser Gln Tyr Gln Glu Leu Ala Val Ala Leu Glu Ser
65                  70                  75                  80  
Ser Ser Val Thr Ile Asn Gln Leu Asn Glu Asn Ile Glu Ser Leu Lys
                85                  90                  95      
Gln Gln Lys Lys Gln Val Glu His Gln Leu Glu Glu Ala Lys Lys Thr
            100                 105                 110         
Asn Asn Glu Ile His Lys Ala Gln Met Glu Gln Leu Glu Thr Ile Asn
        115                 120                 125             
Ile Leu Thr Leu Glu Lys Ala Asp Leu Lys Thr Thr Leu Tyr His Thr
    130                 135                 140                 
Lys Arg Ala Ala Arg His Phe Glu Glu Glu Ser Lys Asp Leu Ala Gly
145                 150                 155                 160 
Arg Leu Gln Tyr Ser Leu Gln His Ile Gln Glu Leu Glu Arg Ala Leu
                165                 170                 175     
Cys Ala Val Ser Thr Gln Gln Gln Glu Glu Asp Arg Ser Ser Ser Cys
            180                 185                 190         
Arg Glu Ala Val Leu Gln Arg Arg Leu Gln Gln Thr Ile Lys Glu Arg
        195                 200                 205             
Ala Leu Leu Asn Ala His Val Thr Gln Val Thr Glu Ser Leu Lys Gln
    210                 215                 220                 
Val Gln Leu Glu Arg Asp Glu Tyr Ala Lys His Ile Lys Gly Glu Arg
225                 230                 235                 240 
Ala Arg Trp Gln Glu Arg Met Trp Lys Met Ser Val Glu Ala Arg Thr
                245                 250                 255     
Leu Lys Glu Glu Lys Lys Arg Asp Ile His Arg Ile Gln Glu Leu Glu
            260                 265                 270         
Arg Ser Leu Ser Glu Leu Lys Asn Gln Met Ala Glu Pro Pro Ser Leu
        275                 280                 285             
Ala Pro Pro Ala Val Thr Ser Val Val Glu Gln Leu Gln Asp Glu Ala
    290                 295                 300                 
Lys His Leu Arg Gln Glu Val Glu Gly Leu Glu Gly Lys Leu Gln Ser
305                 310                 315                 320 
Gln Val Glu Asn Asn Gln Ala Leu Ser Leu Leu Ser Lys Glu Gln Lys
                325                 330                 335     
Gln Arg Leu Gln Glu Gln Glu Glu Met Leu Arg Glu Gln Glu Ala Gln
            340                 345                 350         
Arg Val Arg Glu Gln Glu Arg Leu Cys Glu Gln Asn Glu Arg Leu Arg
        355                 360                 365             
Glu Gln Gln Lys Thr Leu Gln Glu Gln Gly Glu Arg Leu Arg Lys Gln
    370                 375                 380                 
Glu Gln Arg Leu Arg Lys Gln Glu Glu Arg Leu Arg Lys Glu Glu Glu
385                 390                 395                 400 
Arg Leu Gln Lys Gln Glu Lys Arg Leu Trp Asp Gln Glu Glu Arg Leu
                405                 410                 415     
Trp Lys Lys Glu Glu Arg Leu Gln Lys Gln Glu Glu Arg Leu Ala Leu
            420                 425                 430         
Ser Gln Asn His Lys Leu Asp Lys Gln Leu Ala Glu Pro Gln Cys Ser
        435                 440                 445             
Phe Glu Asp Leu Asn Asn Glu Lys Lys Ser Ala Leu Gln Leu Glu Gln
    450                 455                 460                 
Gln Val Lys Glu Leu Gln Glu Lys Leu Asp Glu Glu His Leu Glu Ala
465                 470                 475                 480 
Ala Ser Gln Arg Asn Gln Gln Leu Glu Thr Gln Leu Ser Leu Val Ala
                485                 490                 495     
Leu Pro Gly Glu Gly Asp Gly Gly Gln His Leu Asp Ser Glu Glu Glu
            500                 505                 510         
Glu Ala Pro Arg Pro Thr Pro Asn Ile Pro Glu Asp Leu Glu Ser Arg
        515                 520                 525             
Glu Ala Thr Ser Ser Phe Met Asp Leu Pro Lys Glu Lys Ala Asp Gly
    530                 535                 540                 
Thr Glu Gln Val Glu Arg Arg Glu Leu Gly Phe Val Gln Pro Ser Gly
545                 550                 555                 560 
Val Thr Asp Gly Met Arg Glu Ser Phe Thr Val Tyr Glu Ser Gln Gly
                565                 570                 575     
Ala Val Pro Asn Thr Arg His Gln Glu Met Glu Asp Val Ile Arg Leu
            580                 585                 590         
Ala Gln Lys Glu Glu Glu Met Lys Val Lys Leu Leu Glu Leu Gln Glu
        595                 600                 605             
Leu Val Leu Pro Leu Val Gly Asn His Glu Gly His Gly Lys Phe Leu
    610                 615                 620                 
Ile Ala Ala Gln Asn Pro Ala Asp Glu Pro Thr Pro Gly Ala Pro Ala
625                 630                 635                 640 
Pro Gln Glu Leu Gly Ala Ala Gly Glu Gln Asp Val Phe Tyr Glu Val
                645                 650                 655     
Ser Leu Asp Asn Asn Val Glu Pro Ala Pro Gly Val Ala Arg Glu Gly
            660                 665                 670         
Ser Pro His Asn Asn Pro Thr Val Gln Gln Ile Val Gln Leu Ser Pro
        675                 680                 685             
Val Met Gln Asp Thr
    690             


<210> 1706
<211> 935
<212> PRT
<213> Homo sapiens

<400> 1706
Met Ser Val Glu Ala Tyr Gly Pro Ser Ser Gln Thr Leu Thr Phe Leu
 1               5                  10                  15      
Asp Thr Glu Glu Ala Glu Leu Leu Gly Ala Asp Thr Gln Gly Ser Glu
            20                  25                  30          
Phe Glu Phe Thr Asp Phe Thr Leu Pro Ser Gln Thr Gln Thr Pro Pro
        35                  40                  45              
Gly Gly Pro Gly Gly Pro Gly Gly Gly Gly Ala Gly Gly Pro Gly Gly
    50                  55                  60                  
Ala Gly Ala Gly Ala Ala Ala Gly Gln Leu Asp Ala Gln Val Gly Pro
65                  70                  75                  80  
Glu Gly Ile Leu Gln Asn Gly Ala Val Asp Asp Ser Val Ala Lys Thr
                85                  90                  95      
Ser Gln Leu Leu Ala Glu Leu Asn Phe Glu Glu Asp Glu Glu Asp Thr
            100                 105                 110         
Tyr Tyr Thr Lys Asp Leu Pro Ile His Ala Cys Ser Tyr Cys Gly Ile
        115                 120                 125             
His Asp Pro Ala Cys Val Val Tyr Cys Asn Thr Ser Lys Lys Trp Phe
    130                 135                 140                 
Cys Asn Gly Arg Gly Asn Thr Ser Gly Ser His Ile Val Asn His Leu
145                 150                 155                 160 
Val Arg Ala Lys Cys Lys Glu Val Thr Leu His Lys Asp Gly Pro Leu
                165                 170                 175     
Gly Glu Thr Val Leu Glu Cys Tyr Asn Cys Gly Cys Arg Asn Val Phe
            180                 185                 190         
Leu Leu Gly Phe Ile Pro Ala Lys Ala Asp Ser Val Val Val Leu Leu
        195                 200                 205             
Cys Arg Gln Pro Cys Ala Ser Gln Ser Ser Leu Lys Asp Ile Asn Trp
    210                 215                 220                 
Asp Ser Ser Gln Trp Gln Pro Leu Ile Gln Asp Arg Cys Phe Leu Ser
225                 230                 235                 240 
Trp Leu Val Lys Ile Pro Ser Glu Gln Glu Gln Leu Arg Ala Arg Gln
                245                 250                 255     
Ile Thr Ala Gln Gln Ile Asn Lys Leu Glu Glu Leu Trp Lys Glu Asn
            260                 265                 270         
Pro Ser Ala Thr Leu Glu Asp Leu Glu Lys Pro Gly Val Asp Glu Glu
        275                 280                 285             
Pro Gln His Val Leu Leu Arg Tyr Glu Asp Ala Tyr Gln Tyr Gln Asn
    290                 295                 300                 
Ile Phe Gly Pro Leu Val Lys Leu Glu Ala Asp Tyr Asp Lys Lys Leu
305                 310                 315                 320 
Lys Glu Ser Gln Thr Gln Asp Asn Ile Thr Val Arg Trp Asp Leu Gly
                325                 330                 335     
Leu Asn Lys Lys Arg Ile Ala Tyr Phe Thr Leu Pro Lys Thr Asp Ser
            340                 345                 350         
Asp Met Arg Leu Met Gln Gly Asp Glu Ile Cys Leu Arg Tyr Lys Gly
        355                 360                 365             
Asp Leu Ala Pro Leu Trp Lys Gly Ile Gly His Val Ile Lys Val Pro
    370                 375                 380                 
Asp Asn Tyr Gly Asp Glu Ile Ala Ile Glu Leu Arg Ser Ser Val Gly
385                 390                 395                 400 
Ala Pro Val Glu Val Thr His Asn Phe Gln Val Asp Phe Val Trp Lys
                405                 410                 415     
Ser Thr Ser Phe Asp Arg Met Gln Ser Ala Leu Lys Thr Phe Ala Val
            420                 425                 430         
Asp Glu Thr Ser Val Ser Gly Tyr Ile Tyr His Lys Leu Leu Gly His
        435                 440                 445             
Glu Val Glu Asp Val Ile Ile Lys Cys Gln Leu Pro Lys Arg Phe Thr
    450                 455                 460                 
Ala Gln Gly Leu Pro Asp Leu Asn His Ser Gln Val Tyr Ala Val Lys
465                 470                 475                 480 
Thr Val Leu Gln Arg Pro Leu Ser Leu Ile Gln Gly Pro Pro Gly Thr
                485                 490                 495     
Gly Lys Thr Val Thr Ser Ala Thr Ile Val Tyr His Leu Ala Arg Gln
            500                 505                 510         
Gly Asn Gly Pro Val Leu Val Cys Ala Pro Ser Asn Ile Ala Val Asp
        515                 520                 525             
Gln Leu Thr Glu Lys Ile His Gln Thr Gly Leu Lys Val Val Arg Leu
    530                 535                 540                 
Cys Ala Lys Ser Arg Glu Ala Ile Asp Ser Pro Val Ser Phe Leu Ala
545                 550                 555                 560 
Leu His Asn Gln Ile Arg Asn Met Asp Ser Met Pro Glu Leu Gln Lys
                565                 570                 575     
Leu Gln Gln Leu Lys Asp Glu Thr Gly Glu Leu Ser Ser Ala Asp Glu
            580                 585                 590         
Lys Arg Tyr Arg Ala Leu Lys Arg Thr Ala Glu Arg Glu Leu Leu Met
        595                 600                 605             
Asn Ala Asp Val Ile Cys Cys Thr Cys Val Gly Ala Gly Asp Pro Arg
    610                 615                 620                 
Leu Ala Lys Met Gln Phe Arg Ser Ile Leu Ile Asp Glu Ser Thr Gln
625                 630                 635                 640 
Ala Thr Glu Pro Glu Cys Met Val Pro Val Val Leu Gly Ala Lys Gln
                645                 650                 655     
Leu Ile Leu Val Gly Asp His Cys Gln Leu Gly Pro Val Val Met Cys
            660                 665                 670         
Lys Lys Ala Ala Lys Ala Gly Leu Ser Gln Ser Leu Phe Glu Arg Leu
        675                 680                 685             
Val Val Leu Gly Ile Arg Pro Ile Arg Leu Gln Val Gln Tyr Arg Met
    690                 695                 700                 
His Pro Ala Leu Ser Ala Phe Pro Ser Asn Ile Phe Tyr Glu Gly Ser
705                 710                 715                 720 
Leu Gln Asn Gly Val Thr Ala Ala Asp Arg Val Lys Lys Gly Phe Asp
                725                 730                 735     
Phe Gln Trp Pro Gln Pro Asp Lys Pro Met Phe Phe Tyr Val Thr Gln
            740                 745                 750         
Gly Gln Glu Glu Ile Ala Ser Ser Gly Thr Ser Tyr Leu Asn Arg Thr
        755                 760                 765             
Glu Ala Ala Asn Val Glu Lys Ile Thr Thr Lys Leu Leu Lys Ala Gly
    770                 775                 780                 
Ala Lys Pro Asp Gln Ile Gly Ile Ile Thr Pro Tyr Glu Gly Gln Arg
785                 790                 795                 800 
Ser Tyr Leu Val Gln Tyr Met Gln Phe Ser Gly Ser Leu His Thr Lys
                805                 810                 815     
Leu Tyr Gln Glu Val Glu Ile Ala Ser Val Asp Ala Phe Gln Gly Arg
            820                 825                 830         
Glu Lys Asp Phe Ile Ile Leu Ser Cys Val Arg Ala Asn Glu His Gln
        835                 840                 845             
Gly Ile Gly Phe Leu Asn Asp Pro Arg Arg Leu Asn Val Ala Leu Thr
    850                 855                 860                 
Arg Ala Arg Tyr Gly Val Ile Ile Val Gly Asn Pro Lys Ala Leu Ser
865                 870                 875                 880 
Lys Gln Pro Leu Trp Asn His Leu Leu Asn Tyr Tyr Lys Glu Gln Lys
                885                 890                 895     
Val Leu Val Glu Gly Pro Leu Asn Asn Leu Arg Glu Ser Leu Met Gln
            900                 905                 910         
Phe Ser Lys Pro Arg Lys Leu Val Asn Thr Ile Asn Pro Gly Ser Pro
        915                 920                 925             
Leu His Asp His Ser His Val
    930                 935 


<210> 1707
<211> 82
<212> PRT
<213> Homo sapiens

<400> 1707
Met Thr Ala Lys Met Val Glu Val Met Arg Ser Gly Lys Ile Lys Ala
 1               5                  10                  15      
Leu Arg Thr Ala Pro Leu Ala Arg Tyr Leu Lys Gly Lys Ala Leu Leu
            20                  25                  30          
Thr Ala Arg Arg Thr Leu Ser Arg Glu Asp Arg Asn Gln Lys Thr Lys
        35                  40                  45              
Leu Pro Leu Gln Glu Lys Met Leu Pro Asn Val Leu Tyr Cys Pro Thr
    50                  55                  60                  
Gln Phe Leu Gly Thr Ser Pro Lys Ser Phe Gln Met Leu Tyr Val Glu
65                  70                  75                  80  
Phe Val
        


<210> 1708
<211> 183
<212> PRT
<213> Homo sapiens

<400> 1708
Met Ala Arg Ser Arg Thr Ser Ser Ser Pro Ala Ile Ser Gln Ala Leu
 1               5                  10                  15      
Leu Glu Leu Glu Met Asn Ser Asp Leu Lys Ala Gln Leu Arg Glu Leu
            20                  25                  30          
Asn Ile Thr Ala Ala Lys Glu Thr Glu Val Gly Gly Gly Arg Lys Ala
        35                  40                  45              
Ile Ile Ile Phe Val Pro Val Pro Gln Leu Lys Ser Phe Gln Lys Ile
    50                  55                  60                  
Gln Val Arg Leu Val Arg Glu Leu Glu Lys Lys Phe Ser Gly Lys His
65                  70                  75                  80  
Val Val Phe Ile Ala Gln Arg Arg Ile Leu Pro Lys Pro Thr Gln Lys
                85                  90                  95      
Ser Arg Thr Lys Asn Lys Gln Lys Cys Pro Arg Ser Arg Thr Leu Thr
            100                 105                 110         
Ala Val His Asp Ala Phe Leu Glu Asp Leu Val Phe Pro Ser Glu Ile
        115                 120                 125             
Val Gly Lys Arg Ile Pro Val Lys Leu Asp Ser Ser Arg Leu Ile Lys
    130                 135                 140                 
Val His Leu Asp Lys Ala Gln Gln Asn Asn Val Glu His Lys Val Glu
145                 150                 155                 160 
Thr Phe Ser Gly Val Tyr Lys Lys Leu Thr Gly Lys Asp Val Asn Phe
                165                 170                 175     
Glu Phe Pro Glu Phe Gln Leu
            180             


<210> 1709
<211> 125
<212> PRT
<213> Homo sapiens

<400> 1709
Met Gly Asn Ile Phe Glu Lys Leu Phe Lys Ser Leu Leu Gly Lys Lys
 1               5                  10                  15      
Lys Met Arg Ile Leu Ile Leu Ser Leu Asp Thr Ala Gly Lys Thr Thr
            20                  25                  30          
Ile Leu Tyr Lys Leu Lys Leu Gly Glu Thr Val Pro Ala Val Pro Thr
        35                  40                  45              
Val Gly Phe Cys Val Glu Thr Val Glu Tyr Lys Asn Asn Thr Phe Ala
    50                  55                  60                  
Val Trp Asp Val Gly Ser His Phe Lys Ile Arg Pro Leu Trp Gln His
65                  70                  75                  80  
Phe Phe Gln Asn Thr Lys Glu Leu Ser Ala Ser Gln Phe Ala Gln Phe
                85                  90                  95      
Ile Lys Lys Leu Cys Gly Val Thr Gly Thr Asn Asp Glu Ala Ser Pro
            100                 105                 110         
Gly Ser Leu Thr Ser Tyr Pro Ser His Leu Leu Asp Arg
        115                 120                 125 


<210> 1710
<211> 216
<212> PRT
<213> Homo sapiens

<400> 1710
Met Ala Gly Arg Gly Gly Ala Ala Arg Pro Asn Gly Pro Ala Ala Gly
 1               5                  10                  15      
Asn Lys Ile Cys Gln Phe Lys Leu Val Leu Leu Gly Glu Ser Ala Val
            20                  25                  30          
Gly Lys Ser Ser Leu Val Leu Arg Phe Val Lys Gly Gln Phe His Glu
        35                  40                  45              
Tyr Gln Glu Ser Thr Ile Gly Ala Ala Phe Leu Thr Gln Thr Val Cys
    50                  55                  60                  
Leu Asp Asp Thr Thr Val Lys Phe Glu Ile Trp Asp Thr Ala Gly Gln
65                  70                  75                  80  
Glu Arg Tyr His Ser Leu Ala Pro Met Tyr Tyr Arg Gly Ala Gln Ala
                85                  90                  95      
Ala Ile Val Val Tyr Asp Ile Thr Asn Thr Asp Thr Phe Ala Arg Ala
            100                 105                 110         
Lys Asn Trp Val Lys Glu Leu Gln Arg Gln Ala Ser Pro Asn Ile Val
        115                 120                 125             
Ile Ala Leu Ala Gly Asn Lys Ala Asp Leu Ala Ser Lys Arg Ala Val
    130                 135                 140                 
Glu Phe Gln Glu Ala Gln Ala Tyr Ala Asp Asp Asn Ser Leu Leu Phe
145                 150                 155                 160 
Met Glu Thr Ser Ala Lys Thr Ala Met Asn Val Asn Glu Ile Phe Met
                165                 170                 175     
Ala Ile Ala Lys Lys Leu Pro Lys Asn Glu Pro Gln Asn Ala Thr Gly
            180                 185                 190         
Ala Pro Gly Arg Asn Arg Gly Val Asp Leu Gln Glu Asn Asn Pro Ala
        195                 200                 205             
Ser Arg Ser Gln Cys Cys Ser Asn
    210                 215     


<210> 1711
<211> 592
<212> PRT
<213> Homo sapiens

<400> 1711
Met Met His Pro Gly Gln Pro Pro Ser Ser Cys Glu Lys Thr Thr Val
 1               5                  10                  15      
Ile Ser Cys Val Trp Thr Ser Arg Thr Ser Thr Val Ser Ser Arg Met
            20                  25                  30          
Trp Arg Gln Arg Pro Cys Gly Trp Lys Asn Met Ala Lys Trp Cys Trp
        35                  40                  45              
Cys Trp Arg Glu Pro Leu Arg Ala Pro Ala Leu Pro Asp Pro Gln Pro
    50                  55                  60                  
Gln Ala Gly Thr Gly Tyr Thr Val Met Ser Gly Thr Pro Glu Lys Ile
65                  70                  75                  80  
Leu Glu Leu Leu Leu Glu Ala Met Gly Pro Asp Ser Ser Ala His Asp
                85                  90                  95      
Pro Thr Glu Thr Phe Leu Ser Asp Phe Leu Leu Thr His Arg Val Phe
            100                 105                 110         
Met Pro Ser Ala Gln Leu Cys Ala Ala Leu Leu His His Phe His Val
        115                 120                 125             
Glu Pro Ala Gly Gly Ser Glu Gln Glu Arg Ser Thr Tyr Val Cys Asn
    130                 135                 140                 
Lys Arg Gln Gln Ile Leu Arg Leu Val Ser Gln Trp Val Ala Leu Tyr
145                 150                 155                 160 
Gly Ser Met Leu His Thr Asp Pro Val Ala Thr Ser Phe Leu Gln Lys
                165                 170                 175     
Leu Ser Asp Leu Val Gly Arg Asp Thr Arg Leu Ser Asn Leu Leu Arg
            180                 185                 190         
Glu Gln Trp Pro Glu Arg Arg Arg Cys His Arg Leu Glu Asn Gly Cys
        195                 200                 205             
Gly Asn Ala Ser Pro Gln Met Lys Ala Arg Asn Leu Pro Val Trp Leu
    210                 215                 220                 
Pro Asn Gln Asp Glu Pro Leu Pro Gly Ser Ser Cys Ala Ile Gln Val
225                 230                 235                 240 
Gly Asp Lys Val Pro Tyr Asp Ile Cys Arg Pro Asp His Ser Val Leu
                245                 250                 255     
Thr Leu Gln Leu Pro Val Thr Ala Ser Val Arg Glu Val Met Ala Ala
            260                 265                 270         
Leu Ala Gln Glu Asp Gly Trp Thr Lys Gly Gln Val Leu Val Lys Val
        275                 280                 285             
Asn Ser Ala Gly Asp Ala Ile Gly Leu Gln Pro Asp Ala Arg Gly Val
    290                 295                 300                 
Ala Thr Ser Leu Gly Leu Asn Glu Arg Leu Phe Val Val Asn Pro Gln
305                 310                 315                 320 
Glu Val His Glu Leu Ile Pro His Pro Asp Gln Leu Gly Pro Thr Val
                325                 330                 335     
Gly Ser Ala Glu Gly Leu Asp Leu Val Ser Ala Lys Asp Leu Ala Gly
            340                 345                 350         
Gln Leu Thr Asp His Asp Trp Ser Leu Phe Asn Ser Ile His Gln Val
        355                 360                 365             
Glu Leu Ile His Tyr Val Leu Gly Pro Gln His Leu Arg Asp Val Thr
    370                 375                 380                 
Thr Ala Asn Leu Glu Arg Phe Met Arg Arg Phe Asn Glu Leu Gln Tyr
385                 390                 395                 400 
Trp Val Ala Thr Glu Leu Cys Leu Cys Pro Val Pro Gly Pro Arg Ala
                405                 410                 415     
Gln Leu Leu Arg Lys Phe Ile Lys Leu Ala Ala His Leu Lys Glu Gln
            420                 425                 430         
Lys Asn Leu Asn Ser Phe Phe Ala Val Met Phe Gly Leu Ser Asn Ser
        435                 440                 445             
Ala Ile Ser Arg Leu Ala His Thr Trp Glu Arg Leu Pro His Lys Val
    450                 455                 460                 
Arg Lys Leu Tyr Ser Ala Leu Glu Arg Leu Leu Asp Pro Ser Trp Asn
465                 470                 475                 480 
His Arg Val Tyr Arg Leu Ala Leu Ala Lys Leu Ser Pro Pro Val Ile
                485                 490                 495     
Pro Phe Met Pro Leu Leu Leu Lys Asp Met Thr Phe Ile His Glu Gly
            500                 505                 510         
Asn His Thr Leu Val Glu Asn Leu Ile Asn Phe Glu Lys Met Arg Met
        515                 520                 525             
Met Ala Arg Ala Ala Arg Met Leu His His Cys Arg Ser His Asn Pro
    530                 535                 540                 
Val Pro Leu Ser Pro Leu Arg Ser Arg Val Ser His Leu His Glu Asp
545                 550                 555                 560 
Ser Gln Val Ala Arg Ile Ser Thr Trp Leu Gly Ala Val Pro Glu His
                565                 570                 575     
Pro Glu Ser Ser Gln His Leu Gly Leu Cys Pro Ala Ala Glu Gly His
            580                 585                 590         


<210> 1712
<211> 373
<212> PRT
<213> Homo sapiens

<400> 1712
Met Leu Leu Gln Thr Cys Arg Asp Phe Ala Glu Lys Glu Leu Phe Pro
 1               5                  10                  15      
Ile Ala Ala Gln Val Asp Lys Glu His Leu Phe Pro Ala Ala Gln Val
            20                  25                  30          
Lys Lys Met Gly Gly Leu Gly Leu Leu Ala Met Asp Val Pro Glu Glu
        35                  40                  45              
Leu Gly Gly Ala Gly Leu Asp Tyr Leu Ala Tyr Ala Ile Ala Met Glu
    50                  55                  60                  
Glu Ile Ser Arg Gly Cys Ala Ser Thr Gly Val Ile Met Ser Val Asn
65                  70                  75                  80  
Asn Ser Leu Tyr Leu Gly Pro Ile Leu Lys Phe Gly Ser Lys Glu Gln
                85                  90                  95      
Lys Gln Ala Trp Val Thr Pro Phe Thr Ser Gly Asp Lys Ile Gly Cys
            100                 105                 110         
Phe Ala Leu Ser Glu Pro Gly Asn Gly Ser Asp Ala Gly Ala Ala Ser
        115                 120                 125             
Thr Thr Ala Arg Ala Glu Gly Asp Ser Trp Val Leu Asn Gly Thr Lys
    130                 135                 140                 
Ala Trp Ile Thr Asn Ala Trp Glu Ala Ser Ala Ala Val Val Phe Ala
145                 150                 155                 160 
Ser Thr Asp Arg Ala Leu Gln Asn Lys Gly Ile Ser Ala Phe Leu Val
                165                 170                 175     
Pro Met Pro Thr Pro Gly Leu Thr Leu Gly Lys Lys Glu Asp Lys Leu
            180                 185                 190         
Gly Ile Arg Gly Ser Ser Thr Ala Asn Leu Ile Phe Glu Asp Cys Arg
        195                 200                 205             
Ile Pro Lys Asp Ser Ile Leu Gly Glu Pro Gly Met Gly Phe Lys Ile
    210                 215                 220                 
Ala Met Gln Thr Leu Asp Met Gly Arg Ile Gly Ile Ala Ser Gln Ala
225                 230                 235                 240 
Leu Gly Ile Ala Gln Thr Ala Leu Asp Cys Ala Val Asn Tyr Ala Glu
                245                 250                 255     
Asn Arg Met Ala Phe Gly Ala Pro Leu Thr Lys Leu Gln Val Ile Gln
            260                 265                 270         
Phe Lys Leu Ala Asp Met Ala Leu Ala Leu Glu Ser Ala Arg Leu Leu
        275                 280                 285             
Thr Trp Arg Ala Ala Met Leu Lys Asp Asn Lys Lys Pro Phe Ile Lys
    290                 295                 300                 
Glu Ala Ala Met Ala Lys Leu Ala Ala Ser Glu Ala Ala Thr Ala Ile
305                 310                 315                 320 
Ser His Gln Ala Ile Gln Ile Leu Gly Gly Met Gly Tyr Val Thr Glu
                325                 330                 335     
Met Pro Ala Glu Arg His Tyr Arg Asp Ala Arg Ile Thr Glu Ile Tyr
            340                 345                 350         
Glu Gly Thr Ser Glu Ile Gln Arg Leu Val Ile Ala Gly His Leu Leu
        355                 360                 365             
Arg Ser Tyr Arg Ser
    370             


<210> 1713
<211> 667
<212> PRT
<213> Homo sapiens

<400> 1713
Met Phe Gln Gly Arg Pro Cys Lys Asn Met Tyr Pro Asn Glu Tyr Phe
 1               5                  10                  15      
Pro His Gly Ile Thr Asn Gly Ala Ser Trp Tyr Asn Val Pro Gly Gly
            20                  25                  30          
Met Gln Asp Trp Asn Tyr Leu Gln Thr Asn Cys Phe Glu Val Thr Ile
        35                  40                  45              
Glu Leu Gly Cys Val Lys Tyr Pro Leu Glu Lys Glu Leu Pro Asn Phe
    50                  55                  60                  
Trp Glu Gln Asn Arg Arg Ser Leu Ile Gln Phe Met Lys Gln Val His
65                  70                  75                  80  
Gln Gly Val Arg Gly Phe Val Leu Asp Ala Thr Asp Gly Arg Gly Ile
                85                  90                  95      
Leu Asn Ala Thr Ile Ser Val Ala Glu Ile Asn His Pro Val Thr Thr
            100                 105                 110         
Tyr Lys Thr Gly Asp Tyr Trp Arg Leu Leu Val Pro Gly Thr Tyr Lys
        115                 120                 125             
Ile Thr Ala Ser Ala Arg Gly Tyr Asn Pro Val Thr Lys Asn Val Thr
    130                 135                 140                 
Val Lys Ser Glu Gly Ala Ile Gln Val Asn Phe Thr Leu Val Arg Ser
145                 150                 155                 160 
Ser Thr Asp Ser Asn Asn Glu Ser Lys Lys Gly Lys Gly Ala Ser Ser
                165                 170                 175     
Ser Thr Asn Asp Ala Ser Asp Pro Thr Thr Lys Glu Phe Glu Thr Leu
            180                 185                 190         
Ile Lys Asp Leu Ser Ala Glu Asn Gly Leu Glu Ser Leu Met Leu Arg
        195                 200                 205             
Ser Ser Ser Asn Leu Ala Leu Ala Leu Tyr Arg Tyr His Ser Tyr Lys
    210                 215                 220                 
Asp Leu Ser Glu Phe Leu Arg Gly Leu Val Met Asn Tyr Pro His Ile
225                 230                 235                 240 
Thr Asn Leu Thr Asn Leu Gly Gln Ser Thr Glu Tyr Arg His Ile Trp
                245                 250                 255     
Ser Leu Glu Ile Ser Asn Lys Pro Asn Val Ser Glu Pro Glu Glu Pro
            260                 265                 270         
Lys Ile Arg Phe Val Ala Gly Ile His Gly Asn Ala Pro Val Gly Thr
        275                 280                 285             
Glu Leu Leu Leu Ala Leu Ala Glu Phe Leu Cys Leu Asn Tyr Lys Lys
    290                 295                 300                 
Asn Pro Ala Val Thr Gln Leu Val Asp Arg Thr Arg Ile Val Ile Val
305                 310                 315                 320 
Pro Ser Leu Asn Pro Asp Gly Arg Glu Arg Ala Gln Glu Lys Asp Cys
                325                 330                 335     
Thr Ser Lys Ile Gly Gln Thr Asn Ala Arg Gly Lys Asp Leu Asp Thr
            340                 345                 350         
Asp Phe Thr Asn Asn Ala Ser Gln Pro Glu Thr Lys Ala Ile Ile Glu
        355                 360                 365             
Asn Leu Ile Gln Lys Gln Asp Phe Ser Leu Ser Val Ala Leu Asp Gly
    370                 375                 380                 
Gly Ser Met Leu Val Thr Tyr Pro Tyr Asp Lys Pro Val Gln Thr Val
385                 390                 395                 400 
Glu Asn Lys Glu Thr Leu Lys His Leu Ala Ser Leu Tyr Ala Asn Asn
                405                 410                 415     
His Pro Ser Met His Met Gly Gln Pro Ser Cys Pro Asn Lys Ser Asp
            420                 425                 430         
Glu Asn Ile Pro Gly Gly Val Met Arg Gly Ala Glu Trp His Ser His
        435                 440                 445             
Leu Gly Ser Met Lys Asp Tyr Ser Val Thr Tyr Gly His Cys Pro Glu
    450                 455                 460                 
Ile Thr Val Tyr Thr Ser Cys Cys Tyr Phe Pro Ser Ala Ala Arg Leu
465                 470                 475                 480 
Pro Ser Leu Trp Ala Asp Asn Lys Arg Ser Leu Leu Ser Met Leu Val
                485                 490                 495     
Glu Val His Lys Gly Val His Gly Phe Val Lys Asp Lys Thr Gly Lys
            500                 505                 510         
Pro Ile Ser Lys Ala Val Ile Val Leu Asn Glu Gly Ile Lys Val Gln
        515                 520                 525             
Thr Lys Glu Gly Gly Tyr Phe His Val Leu Leu Ala Pro Gly Val His
    530                 535                 540                 
Asn Ile Ile Ala Ile Ala Asp Gly Tyr Gln Gln Gln His Ser Gln Val
545                 550                 555                 560 
Phe Val His His Asp Ala Ala Ser Ser Val Val Ile Val Phe Asp Thr
                565                 570                 575     
Asp Asn Arg Ile Phe Gly Leu Pro Arg Glu Leu Val Val Thr Val Ser
            580                 585                 590         
Gly Ala Thr Met Ser Ala Leu Ile Leu Thr Ala Cys Ile Ile Trp Cys
        595                 600                 605             
Ile Cys Ser Ile Lys Ser Asn Arg His Lys Asp Gly Phe His Arg Leu
    610                 615                 620                 
Arg Gln His His Asp Glu Tyr Glu Asp Glu Ile Arg Met Met Ser Thr
625                 630                 635                 640 
Gly Ser Lys Lys Ser Leu Leu Ser His Glu Phe Gln Asp Glu Thr Asp
                645                 650                 655     
Thr Glu Glu Glu Thr Leu Tyr Ser Ser Lys His
            660                 665         


<210> 1714
<211> 224
<212> PRT
<213> Homo sapiens

<400> 1714
Met Gly Ile Met Ala Ala Ser Arg Pro Leu Ser Arg Phe Trp Glu Trp
 1               5                  10                  15      
Gly Lys Asn Ile Val Cys Val Gly Arg Asn Tyr Ala Asp His Val Arg
            20                  25                  30          
Glu Met Arg Ser Ala Val Leu Ser Glu Pro Val Leu Phe Leu Lys Pro
        35                  40                  45              
Ser Thr Ala Tyr Ala Pro Glu Gly Ser Pro Ile Leu Met Pro Ala Tyr
    50                  55                  60                  
Thr Arg Asn Leu His His Glu Leu Glu Leu Gly Val Val Met Gly Lys
65                  70                  75                  80  
Arg Cys Arg Ala Val Pro Glu Ala Ala Ala Met Asp Tyr Val Gly Gly
                85                  90                  95      
Tyr Ala Leu Cys Leu Asp Met Thr Ala Arg Asp Val Gln Asp Glu Cys
            100                 105                 110         
Lys Lys Lys Gly Leu Pro Trp Thr Leu Ala Lys Ser Phe Thr Ala Ser
        115                 120                 125             
Cys Pro Val Ser Ala Phe Val Pro Lys Glu Lys Ile Pro Asp Pro His
    130                 135                 140                 
Lys Leu Lys Leu Trp Leu Lys Val Asn Gly Glu Leu Arg Gln Glu Gly
145                 150                 155                 160 
Glu Thr Ser Ser Met Ile Phe Ser Ile Pro Tyr Ile Ile Ser Tyr Val
                165                 170                 175     
Ser Lys Ile Ile Thr Leu Glu Glu Gly Asp Ile Ile Leu Thr Gly Thr
            180                 185                 190         
Pro Lys Gly Val Gly Pro Val Lys Glu Asn Asp Glu Ile Glu Ala Gly
        195                 200                 205             
Ile His Gly Leu Val Ser Met Thr Phe Lys Val Glu Lys Pro Glu Tyr
    210                 215                 220                 


<210> 1715
<211> 109
<212> PRT
<213> Homo sapiens

<400> 1715
Met Ala Ala Ser Ala Ala Arg Gly Ala Ala Ala Leu Arg Arg Ser Ile
 1               5                  10                  15      
Asn Gln Pro Val Ala Phe Val Arg Arg Ile Pro Trp Thr Ala Ala Ser
            20                  25                  30          
Ser Gln Leu Lys Glu His Phe Ala Gln Phe Gly His Val Arg Arg Cys
        35                  40                  45              
Ile Leu Pro Phe Asp Lys Glu Thr Gly Phe His Arg Gly Leu Gly Trp
    50                  55                  60                  
Val Gln Phe Ser Ser Glu Glu Gly Leu Arg Asn Ala Leu Gln Gln Glu
65                  70                  75                  80  
Asn His Ile Ile Asp Gly Val Lys Val Gln Val His Thr Arg Arg Pro
                85                  90                  95      
Lys Leu Pro Gln Thr Ser Asp Asp Glu Lys Lys Asp Phe
            100                 105                 


<210> 1716
<211> 251
<212> PRT
<213> Homo sapiens

<400> 1716
Met Ala His Arg Leu Gln Ile Arg Leu Leu Thr Trp Asp Val Lys Asp
 1               5                  10                  15      
Thr Leu Leu Arg Leu Arg His Pro Leu Gly Glu Ala Tyr Ala Thr Lys
            20                  25                  30          
Ala Arg Ala His Gly Leu Glu Val Glu Pro Ser Ala Leu Glu Gln Gly
        35                  40                  45              
Phe Arg Gln Ala Tyr Arg Ala Gln Ser His Ser Phe Pro Asn Tyr Gly
    50                  55                  60                  
Leu Ser His Gly Leu Thr Ser Arg Gln Trp Trp Leu Asp Val Val Leu
65                  70                  75                  80  
Gln Thr Phe His Leu Ala Gly Val Gln Asp Ala Gln Ala Val Ala Pro
                85                  90                  95      
Ile Ala Glu Gln Leu Tyr Lys Asp Phe Ser His Pro Cys Thr Trp Gln
            100                 105                 110         
Val Leu Asp Gly Ala Glu Asp Thr Leu Arg Glu Cys Arg Thr Arg Gly
        115                 120                 125             
Leu Arg Leu Ala Val Ile Ser Asn Phe Asp Arg Arg Leu Glu Gly Ile
    130                 135                 140                 
Leu Gly Gly Leu Gly Leu Arg Glu His Phe Asp Phe Val Leu Thr Ser
145                 150                 155                 160 
Glu Ala Ala Gly Trp Pro Lys Pro Asp Pro Arg Ile Phe Gln Glu Ala
                165                 170                 175     
Leu Arg Leu Ala His Met Glu Pro Val Val Ala Ala His Val Gly Asp
            180                 185                 190         
Asn Tyr Leu Cys Asp Tyr Gln Gly Pro Arg Ala Val Gly Met His Ser
        195                 200                 205             
Phe Leu Val Val Gly Pro Gln Ala Leu Asp Pro Val Val Arg Asp Ser
    210                 215                 220                 
Val Pro Lys Glu His Ile Leu Pro Ser Leu Ala His Leu Leu Pro Ala
225                 230                 235                 240 
Leu Asp Cys Leu Glu Gly Ser Thr Pro Gly Leu
                245                 250     


<210> 1717
<211> 127
<212> PRT
<213> Homo sapiens

<400> 1717
Met Leu Leu Leu Glu Ile Leu His Glu Ile Lys Ser Phe Pro Leu His
 1               5                  10                  15      
Phe Asp Glu Asn Ser Phe Phe Ala Gly Asp Lys Lys Glu Ala His Lys
            20                  25                  30          
Leu Lys Glu Asp Phe Arg Leu His Phe Arg Asn Ile Ser Arg Ile Met
        35                  40                  45              
Asp Cys Val Gly Cys Phe Lys Cys Arg Leu Trp Gly Lys Leu Gln Thr
    50                  55                  60                  
Gln Gly Leu Gly Thr Ala Leu Lys Ile Leu Phe Ser Glu Lys Leu Ile
65                  70                  75                  80  
Ala Asn Met Pro Glu Ser Gly Pro Ser Tyr Glu Phe His Leu Thr Arg
                85                  90                  95      
Gln Glu Ile Val Ser Leu Phe Asn Ala Phe Gly Arg Ile Ser Thr Ser
            100                 105                 110         
Val Lys Glu Leu Glu Asn Phe Arg Asn Leu Leu Gln Asn Ile His
        115                 120                 125         


<210> 1718
<211> 1388
<212> PRT
<213> Homo sapiens

<400> 1718
Met Thr Pro Leu Asn Lys Thr Lys Thr Ala Leu Gly Phe Leu Leu Trp
 1               5                  10                  15      
Ile Val Cys Trp Ala Asp Leu Phe Tyr Ser Phe Trp Glu Arg Ser Arg
            20                  25                  30          
Gly Ile Phe Leu Ala Pro Val Phe Leu Val Ser Pro Thr Leu Leu Gly
        35                  40                  45              
Ile Thr Met Leu Leu Ala Thr Phe Leu Ile Gln Leu Glu Arg Arg Lys
    50                  55                  60                  
Gly Val Gln Ser Ser Gly Ile Met Leu Thr Phe Trp Leu Val Ala Leu
65                  70                  75                  80  
Val Cys Ala Leu Ala Ile Leu Arg Ser Lys Ile Met Thr Ala Leu Lys
                85                  90                  95      
Glu Asn Pro Cys Pro Glu Ser Ser Ala Ser Phe Leu Ser Arg Ile Thr
            100                 105                 110         
Phe Trp Trp Ile Thr Gly Leu Ile Val Arg Gly Tyr Arg Gln Pro Leu
        115                 120                 125             
Glu Gly Ser Asp Leu Trp Ser Leu Asn Lys Glu Asp Thr Ser Glu Gln
    130                 135                 140                 
Val Val Pro Val Leu Val Lys Asn Trp Lys Lys Glu Cys Ala Lys Thr
145                 150                 155                 160 
Arg Lys Gln Pro Val Lys Val Val Tyr Ser Ser Lys Asp Pro Ala Gln
                165                 170                 175     
Pro Lys Glu Ser Ser Lys Val Asp Ala Asn Glu Glu Val Glu Ala Leu
            180                 185                 190         
Ile Val Lys Ser Pro Gln Lys Glu Trp Asn Pro Ser Leu Phe Lys Val
        195                 200                 205             
Leu Tyr Lys Thr Phe Gly Pro Tyr Phe Leu Met Ser Phe Phe Phe Lys
    210                 215                 220                 
Ala Ile His Asp Leu Met Met Phe Ser Gly Pro Gln Ile Leu Lys Leu
225                 230                 235                 240 
Leu Ile Lys Phe Val Asn Asp Thr Lys Ala Pro Asp Trp Gln Gly Tyr
                245                 250                 255     
Phe Tyr Thr Val Leu Leu Phe Val Thr Ala Cys Leu Gln Thr Leu Val
            260                 265                 270         
Leu His Gln Tyr Phe His Ile Cys Phe Val Ser Gly Met Arg Ile Lys
        275                 280                 285             
Thr Ala Val Ile Gly Ala Val Tyr Arg Lys Ala Leu Val Ile Thr Asn
    290                 295                 300                 
Ser Ala Arg Lys Ser Ser Thr Val Gly Glu Ile Val Asn Leu Met Ser
305                 310                 315                 320 
Val Asp Ala Gln Arg Phe Met Asp Leu Ala Thr Tyr Ile Asn Met Ile
                325                 330                 335     
Trp Ser Ala Pro Leu Gln Val Ile Leu Ala Leu Tyr Leu Leu Trp Leu
            340                 345                 350         
Asn Leu Gly Pro Ser Val Leu Ala Gly Val Ala Val Met Val Leu Met
        355                 360                 365             
Val Pro Val Asn Ala Val Met Ala Met Lys Thr Lys Thr Tyr Gln Val
    370                 375                 380                 
Ala His Met Lys Ser Lys Asp Asn Arg Ile Lys Leu Met Asn Glu Ile
385                 390                 395                 400 
Leu Asn Gly Ile Lys Val Leu Lys Leu Tyr Ala Trp Glu Leu Ala Phe
                405                 410                 415     
Lys Asp Lys Val Leu Ala Ile Arg Gln Glu Glu Leu Lys Val Leu Lys
            420                 425                 430         
Lys Ser Ala Tyr Leu Ser Ala Val Gly Thr Phe Thr Trp Val Cys Thr
        435                 440                 445             
Pro Phe Leu Val Ala Leu Cys Thr Phe Ala Val Tyr Val Thr Ile Asp
    450                 455                 460                 
Glu Asn Asn Ile Leu Asp Ala Gln Thr Ala Phe Val Ser Leu Ala Leu
465                 470                 475                 480 
Phe Asn Ile Leu Arg Phe Pro Leu Asn Ile Leu Pro Met Val Ile Ser
                485                 490                 495     
Ser Ile Val Gln Ala Ser Val Ser Leu Lys Arg Leu Arg Ile Phe Leu
            500                 505                 510         
Ser His Glu Glu Leu Glu Pro Asp Ser Ile Glu Arg Arg Pro Val Lys
        515                 520                 525             
Asp Gly Gly Gly Thr Asn Ser Ile Thr Val Arg Asn Ala Thr Phe Thr
    530                 535                 540                 
Trp Ala Arg Ser Asp Pro Pro Thr Leu Asn Gly Ile Thr Phe Ser Ile
545                 550                 555                 560 
Pro Glu Gly Ala Leu Val Ala Val Val Gly Gln Val Gly Cys Gly Lys
                565                 570                 575     
Ser Ser Leu Leu Ser Ala Leu Leu Ala Glu Met Asp Lys Val Glu Gly
            580                 585                 590         
His Val Ala Ile Lys Gly Ser Val Ala Tyr Val Pro Gln Gln Ala Trp
        595                 600                 605             
Ile Gln Asn Asp Ser Leu Arg Glu Asn Ile Leu Phe Gly Cys Gln Leu
    610                 615                 620                 
Glu Glu Pro Tyr Tyr Arg Ser Val Ile Gln Ala Cys Ala Leu Leu Pro
625                 630                 635                 640 
Asp Leu Glu Ile Leu Pro Ser Gly Asp Arg Thr Glu Ile Gly Glu Lys
                645                 650                 655     
Gly Val Asn Leu Ser Gly Gly Gln Lys Gln Arg Val Ser Leu Ala Arg
            660                 665                 670         
Ala Val Tyr Ser Asn Ala Asp Ile Tyr Leu Phe Asp Asp Pro Leu Ser
        675                 680                 685             
Ala Val Asp Ala His Val Gly Lys His Ile Phe Glu Asn Val Ile Gly
    690                 695                 700                 
Pro Lys Gly Met Leu Lys Asn Lys Thr Arg Ile Leu Val Thr His Ser
705                 710                 715                 720 
Met Ser Tyr Leu Pro Gln Val Asp Val Ile Ile Val Met Ser Gly Gly
                725                 730                 735     
Lys Ile Ser Glu Met Gly Ser Tyr Gln Glu Leu Leu Ala Arg Asp Gly
            740                 745                 750         
Ala Phe Ala Glu Phe Leu Arg Thr Tyr Ala Ser Thr Glu Gln Glu Gln
        755                 760                 765             
Asp Ala Glu Glu Asn Gly Val Thr Gly Val Ser Gly Pro Gly Lys Glu
    770                 775                 780                 
Ala Lys Gln Met Glu Asn Gly Met Leu Val Thr Asp Ser Ala Gly Lys
785                 790                 795                 800 
Gln Leu Gln Arg Gln Leu Ser Ser Ser Ser Ser Tyr Ser Gly Asp Ile
                805                 810                 815     
Ser Arg His His Asn Ser Thr Ala Glu Leu Gln Lys Ala Glu Ala Lys
            820                 825                 830         
Lys Glu Glu Thr Trp Lys Leu Met Glu Ala Asp Lys Ala Gln Thr Gly
        835                 840                 845             
Gln Val Lys Leu Ser Val Tyr Trp Asp Tyr Met Lys Ala Ile Gly Leu
    850                 855                 860                 
Phe Ile Ser Phe Leu Ser Ile Phe Leu Phe Met Cys Asn His Val Ser
865                 870                 875                 880 
Ala Leu Ala Ser Asn Tyr Trp Leu Ser Leu Trp Thr Asp Asp Pro Ile
                885                 890                 895     
Val Asn Gly Thr Gln Glu His Thr Lys Val Arg Leu Ser Val Tyr Gly
            900                 905                 910         
Ala Leu Gly Ile Ser Gln Gly Ile Ala Val Phe Gly Tyr Ser Met Ala
        915                 920                 925             
Val Ser Ile Gly Gly Ile Leu Ala Ser Arg Cys Leu His Val Asp Leu
    930                 935                 940                 
Leu His Ser Ile Leu Arg Ser Pro Met Ser Phe Phe Glu Arg Thr Pro
945                 950                 955                 960 
Ser Gly Asn Leu Val Asn Arg Phe Ser Lys Glu Leu Asp Thr Val Asp
                965                 970                 975     
Ser Met Ile Pro Glu Val Ile Lys Met Phe Met Gly Ser Leu Phe Asn
            980                 985                 990         
Val Ile Gly Ala Cys Ile Val Ile Leu Leu Ala Thr Pro Ile Ala Ala
        995                 1000                1005            
Ile Ile Ile Pro Pro Leu Gly Leu Ile Tyr Phe Phe Val Gln Arg Phe
    1010                1015                1020                
Tyr Val Ala Ser Ser Arg Gln Leu Lys Arg Leu Glu Ser Val Ser Arg
1025                1030                1035                1040
Ser Pro Val Tyr Ser His Phe Asn Glu Thr Leu Leu Gly Val Ser Val
                1045                1050                1055    
Ile Arg Ala Phe Glu Glu Gln Glu Arg Phe Ile His Gln Ser Asp Leu
            1060                1065                1070        
Lys Val Asp Glu Asn Gln Lys Ala Tyr Tyr Pro Ser Ile Val Ala Asn
        1075                1080                1085            
Arg Trp Leu Ala Val Arg Leu Glu Cys Val Gly Asn Cys Ile Val Leu
    1090                1095                1100                
Phe Ala Ala Leu Phe Ala Val Ile Ser Arg His Ser Leu Ser Ala Gly
1105                1110                1115                1120
Leu Val Gly Leu Ser Val Ser Tyr Ser Leu Gln Val Thr Thr Tyr Leu
                1125                1130                1135    
Asn Trp Leu Val Arg Met Ser Ser Glu Met Glu Thr Asn Ile Val Ala
            1140                1145                1150        
Val Glu Arg Leu Lys Glu Tyr Ser Glu Thr Glu Lys Glu Ala Pro Trp
        1155                1160                1165            
Gln Ile Gln Glu Thr Ala Pro Pro Ser Ser Trp Pro Gln Val Gly Arg
    1170                1175                1180                
Val Glu Phe Arg Asn Tyr Cys Leu Arg Tyr Arg Glu Asp Leu Asp Phe
1185                1190                1195                1200
Val Leu Arg His Ile Asn Val Thr Ile Asn Gly Gly Glu Lys Val Gly
                1205                1210                1215    
Ile Val Gly Arg Thr Gly Ala Gly Lys Ser Ser Leu Thr Leu Gly Leu
            1220                1225                1230        
Phe Arg Ile Asn Glu Ser Ala Glu Gly Glu Ile Ile Ile Asp Gly Ile
        1235                1240                1245            
Asn Ile Ala Lys Ile Gly Leu His Asp Leu Arg Phe Lys Ile Thr Ile
    1250                1255                1260                
Ile Pro Gln Asp Pro Val Leu Phe Ser Gly Ser Leu Arg Met Asn Leu
1265                1270                1275                1280
Asp Pro Phe Ser Gln Tyr Ser Asp Glu Glu Val Trp Thr Ser Leu Glu
                1285                1290                1295    
Leu Ala His Leu Lys Asp Phe Val Ser Ala Leu Pro Asp Lys Leu Asp
            1300                1305                1310        
His Glu Cys Ala Glu Gly Gly Glu Asn Leu Ser Val Gly Gln Arg Gln
        1315                1320                1325            
Leu Val Cys Leu Ala Arg Ala Leu Leu Arg Lys Thr Lys Ile Leu Val
    1330                1335                1340                
Leu Asp Glu Ala Thr Ala Ala Val Asp Leu Glu Thr Asp Asp Leu Ile
1345                1350                1355                1360
Gln Ser Thr Ile Arg Thr Gln Phe Glu Asp Cys Thr Val Leu Thr Ile
                1365                1370                1375    
Ala His Arg Leu Asn Thr Ile Met Asp Tyr Thr Arg
            1380                1385            


<210> 1719
<211> 135
<212> PRT
<213> Homo sapiens

<400> 1719
Met Ser Ala Ser Ala Asp Val Leu Ala Leu Ala Lys Ile Glu Ile Lys
 1               5                  10                  15      
Leu Ser Asp Ile Pro Glu Gly Lys Asn Met Ala Phe Lys Trp Arg Gly
            20                  25                  30          
Lys Pro Leu Phe Val Arg His Arg Thr Gln Lys Glu Ile Lys Gln Glu
        35                  40                  45              
Ala Ala Val Glu Leu Ser Gln Leu Arg Asp Pro Gln His Asp Leu Asp
    50                  55                  60                  
Arg Val Lys Lys Pro Glu Trp Val Ile Leu Ile Gly Val Cys Thr His
65                  70                  75                  80  
Leu Gly Cys Val Pro Ile Ala Asn Ala Gly Asp Phe Gly Gly Tyr Tyr
                85                  90                  95      
Cys Pro Cys His Gly Ser His Tyr Asp Ala Ser Gly Arg Ile Arg Leu
            100                 105                 110         
Gly Pro Ala Thr Leu Asn Leu Glu Val Pro Thr Tyr Glu Phe Thr Ser
        115                 120                 125             
Asp Asp Met Val Ile Val Gly
    130                 135 


<210> 1720
<211> 543
<212> PRT
<213> Homo sapiens

<400> 1720
Met Phe Ser Trp Leu Lys Arg Gly Gly Ala Arg Gly Gln Gln Pro Glu
 1               5                  10                  15      
Ala Ile Arg Thr Val Thr Ser Ala Leu Lys Glu Leu Tyr Arg Thr Lys
            20                  25                  30          
Leu Leu Pro Leu Glu Glu His Tyr Arg Phe Gly Ala Phe His Ser Pro
        35                  40                  45              
Ala Leu Glu Asp Ala Asp Phe Asp Gly Lys Pro Met Val Leu Val Ala
    50                  55                  60                  
Gly Gln Tyr Ser Thr Gly Lys Thr Ser Phe Ile Gln Tyr Leu Leu Glu
65                  70                  75                  80  
Gln Glu Val Pro Gly Ser Arg Val Gly Pro Glu Pro Thr Thr Asp Cys
                85                  90                  95      
Phe Val Ala Val Met His Gly Asp Thr Glu Gly Thr Val Pro Gly Asn
            100                 105                 110         
Ala Leu Val Val Asp Pro Asp Lys Pro Phe Arg Lys Leu Asn Pro Phe
        115                 120                 125             
Gly Asn Thr Phe Leu Asn Arg Phe Met Cys Ala Gln Leu Pro Asn Gln
    130                 135                 140                 
Val Leu Glu Ser Ile Ser Ile Ile Asp Thr Pro Gly Ile Leu Ser Gly
145                 150                 155                 160 
Ala Lys Gln Arg Val Ser Arg Gly Tyr Asp Phe Pro Ala Val Leu Arg
                165                 170                 175     
Trp Phe Ala Glu Arg Val Asp Leu Ile Ile Leu Leu Phe Asp Ala His
            180                 185                 190         
Lys Leu Glu Ile Ser Asp Glu Phe Ser Glu Ala Ile Gly Ala Leu Arg
        195                 200                 205             
Gly His Glu Asp Lys Ile Arg Val Val Leu Asn Lys Ala Asp Met Val
    210                 215                 220                 
Glu Thr Gln Gln Leu Met Arg Val Tyr Gly Ala Leu Met Trp Ala Leu
225                 230                 235                 240 
Gly Lys Val Val Gly Thr Pro Glu Val Leu Arg Val Tyr Ile Gly Ser
                245                 250                 255     
Phe Trp Ser Gln Pro Leu Leu Val Pro Asp Asn Arg Arg Leu Phe Glu
            260                 265                 270         
Leu Glu Glu Gln Asp Leu Phe Arg Asp Ile Gln Gly Leu Pro Arg His
        275                 280                 285             
Ala Ala Leu Arg Lys Leu Asn Asp Leu Val Lys Arg Ala Arg Leu Val
    290                 295                 300                 
Arg Val His Ala Tyr Ile Ile Ser Tyr Leu Lys Lys Glu Met Pro Ser
305                 310                 315                 320 
Val Phe Gly Lys Glu Asn Lys Lys Lys Gln Leu Ile Leu Lys Leu Pro
                325                 330                 335     
Val Ile Phe Ala Lys Ile Gln Leu Glu His His Ile Ser Pro Gly Asp
            340                 345                 350         
Phe Pro Asp Cys Gln Lys Met Gln Glu Leu Leu Met Ala His Asp Phe
        355                 360                 365             
Thr Lys Phe His Ser Leu Lys Pro Lys Leu Leu Glu Ala Leu Asp Glu
    370                 375                 380                 
Met Leu Thr His Asp Ile Ala Lys Leu Met Pro Leu Leu Arg Gln Glu
385                 390                 395                 400 
Glu Leu Glu Ser Thr Glu Val Gly Val Gln Gly Gly Ala Phe Glu Gly
                405                 410                 415     
Thr His Met Gly Pro Phe Val Glu Arg Gly Pro Asp Glu Ala Met Glu
            420                 425                 430         
Asp Gly Glu Glu Gly Ser Asp Asp Glu Ala Glu Trp Val Val Thr Lys
        435                 440                 445             
Asp Lys Ser Lys Tyr Asp Glu Ile Phe Tyr Asn Leu Ala Pro Ala Asp
    450                 455                 460                 
Gly Lys Leu Ser Gly Ser Lys Ala Lys Thr Trp Met Val Gly Thr Lys
465                 470                 475                 480 
Leu Pro Asn Ser Val Leu Gly Arg Ile Trp Lys Leu Ser Asp Val Asp
                485                 490                 495     
Arg Asp Gly Met Leu Asp Asp Glu Glu Phe Ala Leu Ala Ser His Leu
            500                 505                 510         
Ile Glu Ala Lys Leu Glu Gly His Gly Leu Pro Ala Asn Leu Pro Arg
        515                 520                 525             
Arg Leu Val Pro Pro Ser Lys Arg Arg His Lys Gly Ser Ala Glu
    530                 535                 540             


<210> 1721
<211> 50
<212> PRT
<213> Homo sapiens

<400> 1721
Met Arg Ala Asp Gln Pro Ala Thr Pro Gly Leu Pro Leu Ser Pro His
 1               5                  10                  15      
Leu Asp Ala Gly Ala Val Ala Ala Pro Gln Pro Arg Ser Leu Ala Ala
            20                  25                  30          
Ala Thr Arg Pro Gln Ala Ser Gly Ala Gly Gly Gly Pro Arg Ser Pro
        35                  40                  45              
Trp Gly
    50  


<210> 1722
<211> 463
<212> PRT
<213> Homo sapiens

<400> 1722
Met Ala Ser Ser Pro Ala Val Leu Arg Ala Ser Arg Leu Tyr Gln Trp
 1               5                  10                  15      
Ser Leu Lys Ser Ser Ala Gln Phe Leu Gly Ser Pro Gln Leu Arg Gln
            20                  25                  30          
Val Gly Gln Ile Ile Arg Val Pro Ala Arg Met Ala Ala Thr Leu Ile
        35                  40                  45              
Leu Glu Pro Ala Gly Arg Cys Cys Trp Asp Glu Pro Val Arg Ile Ala
    50                  55                  60                  
Val Arg Gly Leu Ala Pro Glu Gln Pro Val Thr Leu Arg Ala Ser Leu
65                  70                  75                  80  
Arg Asp Glu Lys Gly Ala Leu Phe Gln Ala His Ala Arg Tyr Arg Ala
                85                  90                  95      
Asp Thr Leu Gly Glu Leu Asp Leu Glu Arg Ala Pro Ala Leu Gly Gly
            100                 105                 110         
Ser Phe Ala Gly Leu Glu Pro Met Gly Leu Leu Trp Ala Leu Glu Pro
        115                 120                 125             
Glu Lys Pro Leu Val Arg Leu Val Lys Arg Asp Val Arg Thr Pro Leu
    130                 135                 140                 
Ala Val Glu Leu Glu Val Leu Asp Gly His Asp Pro Asp Pro Gly Arg
145                 150                 155                 160 
Leu Leu Cys Gln Thr Arg His Glu Arg Tyr Phe Leu Pro Pro Gly Val
                165                 170                 175     
Arg Arg Glu Pro Val Arg Val Gly Arg Val Arg Gly Thr Leu Phe Leu
            180                 185                 190         
Pro Pro Glu Pro Gly Pro Phe Pro Gly Ile Val Asp Met Phe Gly Thr
        195                 200                 205             
Gly Gly Gly Leu Leu Glu Tyr Arg Ala Ser Leu Leu Ala Gly Lys Gly
    210                 215                 220                 
Phe Ala Val Met Ala Leu Ala Tyr Tyr Asn Tyr Glu Asp Leu Pro Lys
225                 230                 235                 240 
Thr Met Glu Thr Leu His Leu Glu Tyr Phe Glu Glu Ala Met Asn Tyr
                245                 250                 255     
Leu Leu Ser His Pro Glu Val Lys Gly Pro Gly Val Gly Leu Leu Gly
            260                 265                 270         
Ile Ser Lys Gly Gly Glu Leu Cys Leu Ser Met Ala Ser Phe Leu Lys
        275                 280                 285             
Gly Ile Thr Ala Ala Val Val Ile Asn Gly Ser Val Ala Asn Val Gly
    290                 295                 300                 
Gly Thr Leu Arg Tyr Lys Gly Glu Thr Leu Pro Pro Val Gly Val Asn
305                 310                 315                 320 
Arg Asn Arg Ile Lys Val Thr Lys Asp Gly Tyr Ala Asp Ile Val Asp
                325                 330                 335     
Val Leu Asn Ser Pro Leu Glu Gly Pro Asp Gln Lys Ser Phe Ile Pro
            340                 345                 350         
Val Glu Arg Ala Glu Ser Thr Phe Leu Phe Leu Val Gly Gln Asp Asp
        355                 360                 365             
His Asn Trp Lys Ser Glu Phe Tyr Ala Asn Glu Ala Cys Lys Arg Leu
    370                 375                 380                 
Gln Ala His Gly Arg Arg Lys Pro Gln Ile Ile Cys Tyr Pro Glu Thr
385                 390                 395                 400 
Gly His Tyr Ile Glu Pro Pro Tyr Phe Pro Leu Cys Arg Ala Ser Leu
                405                 410                 415     
His Ala Leu Val Gly Ser Pro Ile Ile Trp Gly Gly Glu Pro Arg Ala
            420                 425                 430         
His Ala Met Ala Gln Val Asp Ala Trp Lys Gln Leu Gln Thr Phe Phe
        435                 440                 445             
His Lys His Leu Gly Gly Arg Glu Gly Thr Ile Pro Ser Lys Val
    450                 455                 460             


<210> 1723
<211> 639
<212> PRT
<213> Homo sapiens

<400> 1723
Met Ser Ala Arg Gly Pro Ala Ile Gly Ile Asp Leu Gly Thr Thr Tyr
 1               5                  10                  15      
Ser Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn
            20                  25                  30          
Asp Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr
        35                  40                  45              
Glu Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Met Asn Pro
    50                  55                  60                  
Thr Asn Thr Ile Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe Glu
65                  70                  75                  80  
Asp Ala Thr Val Gln Ser Asp Met Lys His Trp Pro Phe Arg Val Val
                85                  90                  95      
Ser Glu Gly Gly Lys Pro Lys Val Gln Val Glu Tyr Lys Gly Glu Thr
            100                 105                 110         
Lys Thr Phe Phe Pro Glu Glu Ile Ser Ser Met Val Leu Thr Lys Met
        115                 120                 125             
Lys Glu Ile Ala Glu Ala Tyr Leu Gly Gly Lys Val His Ser Ala Val
    130                 135                 140                 
Ile Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys
145                 150                 155                 160 
Asp Ala Gly Thr Ile Thr Gly Leu Asn Val Leu Arg Ile Ile Asn Glu
                165                 170                 175     
Pro Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Lys Lys Gly Cys Ala
            180                 185                 190         
Gly Gly Glu Lys Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe
        195                 200                 205             
Asp Val Ser Ile Leu Thr Ile Glu Asp Gly Ile Phe Glu Val Lys Ser
    210                 215                 220                 
Thr Ala Gly Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Met
225                 230                 235                 240 
Val Ser His Leu Ala Glu Glu Phe Lys Arg Lys His Lys Lys Asp Ile
                245                 250                 255     
Gly Pro Asn Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg
            260                 265                 270         
Ala Lys Arg Thr Leu Ser Ser Ser Thr Gln Ala Ser Ile Glu Ile Asp
        275                 280                 285             
Ser Leu Tyr Glu Gly Val Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg
    290                 295                 300                 
Phe Glu Glu Leu Asn Ala Asp Leu Phe Arg Gly Thr Leu Glu Pro Val
305                 310                 315                 320 
Glu Lys Ala Leu Arg Asp Ala Lys Leu Asp Lys Gly Gln Ile Gln Glu
                325                 330                 335     
Ile Val Leu Val Gly Gly Ser Thr Arg Ile Pro Lys Ile Gln Lys Leu
            340                 345                 350         
Leu Gln Asp Phe Phe Asn Gly Lys Glu Leu Asn Lys Ser Ile Asn Pro
        355                 360                 365             
Asp Glu Ala Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Ile
    370                 375                 380                 
Gly Asp Lys Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Thr
385                 390                 395                 400 
Pro Leu Ser Leu Gly Ile Glu Thr Ala Gly Gly Val Met Thr Pro Leu
                405                 410                 415     
Ile Lys Arg Asn Thr Thr Ile Pro Thr Lys Gln Thr Gln Thr Phe Thr
            420                 425                 430         
Thr Tyr Ser Asp Asn Gln Ser Ser Val Leu Val Gln Val Tyr Glu Gly
        435                 440                 445             
Glu Arg Ala Met Thr Lys Asp Asn Asn Leu Leu Gly Lys Phe Asp Leu
    450                 455                 460                 
Thr Gly Ile Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr
465                 470                 475                 480 
Phe Asp Ile Asp Ala Asn Gly Ile Leu Asn Val Thr Ala Ala Asp Lys
                485                 490                 495     
Ser Thr Gly Lys Glu Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg
            500                 505                 510         
Leu Ser Lys Asp Asp Ile Asp Arg Met Val Gln Glu Ala Glu Arg Tyr
        515                 520                 525             
Lys Ser Glu Asp Glu Ala Asn Arg Asp Arg Val Ala Ala Lys Asn Ala
    530                 535                 540                 
Leu Glu Ser Tyr Thr Tyr Asn Ile Lys Gln Thr Val Glu Asp Glu Lys
545                 550                 555                 560 
Leu Arg Gly Lys Ile Ser Glu Gln Asp Lys Asn Lys Ile Leu Asp Lys
                565                 570                 575     
Cys Gln Glu Val Ile Asn Trp Leu Asp Arg Asn Gln Met Ala Glu Lys
            580                 585                 590         
Asp Glu Tyr Glu His Lys Gln Lys Glu Leu Glu Arg Val Cys Asn Pro
        595                 600                 605             
Ile Ile Ser Lys Leu Tyr Gln Gly Gly Pro Gly Gly Gly Ser Gly Gly
    610                 615                 620                 
Gly Gly Ser Gly Ala Ser Gly Gly Pro Thr Ile Glu Glu Val Asp
625                 630                 635                 


<210> 1724
<211> 1437
<212> PRT
<213> Homo sapiens

<400> 1724
Met Asp Phe Ser Phe Ser Phe Met Gln Gly Ile Met Gly Asn Thr Ile
 1               5                  10                  15      
Gln Gln Pro Pro Gln Leu Ile Asp Ser Ala Asn Ile Arg Gln Glu Asp
            20                  25                  30          
Ala Phe Asp Asn Asn Ser Asp Ile Ala Glu Asp Gly Gly Gln Thr Pro
        35                  40                  45              
Tyr Glu Ala Thr Leu Gln Gln Gly Phe Gln Tyr Pro Ala Thr Thr Glu
    50                  55                  60                  
Asp Leu Pro Pro Leu Thr Asn Gly Tyr Pro Ser Ser Ile Ser Val Tyr
65                  70                  75                  80  
Glu Thr Gln Thr Lys Tyr Gln Ser Tyr Asn Gln Tyr Pro Asn Gly Ser
                85                  90                  95      
Ala Asn Gly Phe Gly Ala Val Arg Asn Phe Ser Pro Thr Asp Tyr Tyr
            100                 105                 110         
His Ser Glu Ile Pro Asn Thr Arg Pro His Glu Ile Leu Glu Lys Pro
        115                 120                 125             
Ser Pro Pro Gln Pro Pro Pro Pro Pro Ser Val Pro Gln Thr Val Ile
    130                 135                 140                 
Pro Lys Lys Thr Gly Ser Pro Glu Ile Lys Leu Lys Ile Thr Lys Thr
145                 150                 155                 160 
Ile Gln Asn Gly Arg Glu Leu Phe Glu Ser Ser Leu Cys Gly Asp Leu
                165                 170                 175     
Leu Asn Glu Val Gln Ala Ser Glu His Thr Lys Ser Lys His Glu Ser
            180                 185                 190         
Arg Lys Glu Lys Arg Lys Lys Ser Asn Lys His Asp Ser Ser Arg Ser
        195                 200                 205             
Glu Glu Arg Lys Ser His Lys Ile Pro Lys Leu Glu Pro Glu Glu Gln
    210                 215                 220                 
Asn Arg Pro Asn Glu Arg Val Asp Thr Val Ser Glu Lys Pro Arg Glu
225                 230                 235                 240 
Glu Pro Val Leu Lys Glu Glu Ala Pro Val Gln Pro Ile Leu Ser Ser
                245                 250                 255     
Val Pro Thr Thr Glu Val Ser Thr Gly Val Lys Phe Gln Val Gly Asp
            260                 265                 270         
Leu Val Trp Ser Lys Val Gly Thr Tyr Pro Trp Trp Pro Cys Met Val
        275                 280                 285             
Ser Ser Asp Pro Gln Leu Glu Val His Thr Lys Ile Asn Thr Arg Gly
    290                 295                 300                 
Ala Arg Glu Tyr His Val Gln Phe Phe Ser Asn Gln Pro Glu Arg Ala
305                 310                 315                 320 
Trp Val His Glu Lys Arg Val Arg Glu Tyr Lys Gly His Lys Gln Tyr
                325                 330                 335     
Glu Glu Leu Leu Ala Glu Ala Thr Lys Gln Ala Ser Asn His Ser Glu
            340                 345                 350         
Lys Gln Lys Ile Arg Lys Pro Arg Pro Gln Arg Glu Arg Ala Gln Trp
        355                 360                 365             
Asp Ile Gly Ile Ala His Ala Glu Lys Ala Leu Lys Met Thr Arg Glu
    370                 375                 380                 
Glu Arg Ile Glu Gln Tyr Thr Phe Ile Tyr Ile Asp Lys Gln Pro Glu
385                 390                 395                 400 
Glu Ala Leu Ser Gln Ala Lys Lys Ser Val Ala Ser Lys Thr Glu Val
                405                 410                 415     
Lys Lys Thr Arg Arg Pro Arg Ser Val Leu Asn Thr Gln Pro Glu Gln
            420                 425                 430         
Thr Asn Ala Gly Glu Val Ala Ser Ser Leu Ser Ser Thr Glu Ile Arg
        435                 440                 445             
Arg His Ser Gln Arg Arg His Thr Ser Ala Glu Glu Glu Glu Pro Pro
    450                 455                 460                 
Pro Val Lys Ile Ala Trp Lys Thr Ala Ala Ala Arg Lys Ser Leu Pro
465                 470                 475                 480 
Ala Ser Ile Thr Met His Lys Gly Ser Leu Asp Leu Gln Lys Cys Asn
                485                 490                 495     
Met Ser Pro Val Val Lys Ile Glu Gln Val Phe Ala Leu Gln Asn Ala
            500                 505                 510         
Thr Gly Asp Gly Lys Phe Ile Asp Gln Phe Val Tyr Ser Thr Lys Gly
        515                 520                 525             
Ile Gly Asn Lys Thr Glu Ile Ser Val Arg Gly Gln Asp Arg Leu Ile
    530                 535                 540                 
Ile Ser Thr Pro Asn Gln Arg Asn Glu Lys Pro Thr Gln Ser Val Ser
545                 550                 555                 560 
Ser Pro Glu Ala Thr Ser Gly Ser Thr Gly Ser Val Glu Lys Lys Gln
                565                 570                 575     
Gln Arg Arg Ser Ile Arg Thr Arg Ser Glu Ser Glu Lys Ser Thr Glu
            580                 585                 590         
Val Val Pro Lys Lys Lys Ile Lys Lys Glu Gln Val Glu Thr Val Pro
        595                 600                 605             
Gln Ala Thr Val Lys Thr Gly Leu Gln Lys Gly Ala Ser Glu Ile Ser
    610                 615                 620                 
Asp Ser Cys Lys Pro Leu Lys Lys Arg Ser Arg Ala Ser Thr Asp Val
625                 630                 635                 640 
Glu Met Thr Ser Ser Ala Tyr Arg Asp Thr Ser Asp Ser Asp Ser Arg
                645                 650                 655     
Gly Leu Ser Asp Leu Gln Val Gly Phe Gly Lys Gln Val Asp Ser Pro
            660                 665                 670         
Ser Ala Thr Ala Asp Ala Asp Val Ser Asp Val Gln Ser Met Asp Ser
        675                 680                 685             
Ser Leu Ser Arg Arg Gly Thr Gly Met Ser Lys Lys Asp Thr Val Cys
    690                 695                 700                 
Gln Ile Cys Glu Ser Ser Gly Asp Ser Leu Ile Pro Cys Glu Gly Glu
705                 710                 715                 720 
Cys Cys Lys His Phe His Leu Glu Cys Leu Gly Leu Ala Ser Leu Pro
                725                 730                 735     
Asp Ser Lys Phe Ile Cys Met Glu Cys Lys Thr Gly Gln His Pro Cys
            740                 745                 750         
Phe Ser Cys Lys Val Ser Gly Lys Asp Val Lys Arg Cys Ser Val Gly
        755                 760                 765             
Ala Cys Gly Lys Phe Tyr His Glu Ala Cys Val Arg Lys Phe Pro Thr
    770                 775                 780                 
Ala Ile Phe Glu Ser Lys Gly Phe Arg Cys Pro Gln His Cys Cys Ser
785                 790                 795                 800 
Ala Cys Ser Met Glu Lys Asp Ile His Lys Ala Ser Lys Gly Arg Met
                805                 810                 815     
Met Arg Cys Leu Arg Cys Pro Val Ala Tyr His Ser Gly Asp Ala Cys
            820                 825                 830         
Ile Ala Ala Gly Ser Met Leu Val Ser Ser Tyr Ile Leu Ile Cys Ser
        835                 840                 845             
Asn His Ser Lys Arg Ser Ser Asn Ser Ser Ala Val Asn Val Gly Phe
    850                 855                 860                 
Cys Phe Val Cys Ala Arg Gly Leu Ile Val Gln Asp His Ser Asp Pro
865                 870                 875                 880 
Met Phe Ser Ser Tyr Ala Tyr Lys Ser His Tyr Leu Leu Asn Glu Ser
                885                 890                 895     
Asn Arg Ala Glu Leu Met Lys Leu Pro Met Ile Pro Ser Ser Ser Ala
            900                 905                 910         
Ser Lys Lys Lys Cys Glu Lys Gly Gly Arg Leu Leu Cys Cys Glu Ser
        915                 920                 925             
Cys Pro Ala Ser Phe His Pro Glu Cys Leu Ser Ile Glu Met Pro Glu
    930                 935                 940                 
Gly Cys Trp Asn Cys Asn Asp Cys Lys Ala Gly Lys Lys Leu His Tyr
945                 950                 955                 960 
Lys Gln Ile Val Trp Val Lys Leu Gly Asn Tyr Arg Trp Trp Pro Ala
                965                 970                 975     
Glu Ile Cys Asn Pro Arg Ser Val Pro Leu Asn Ile Gln Gly Leu Lys
            980                 985                 990         
His Asp Leu Gly Asp Phe Pro Val Phe Phe Phe Gly Ser His Asp Tyr
        995                 1000                1005            
Tyr Trp Val His Gln Gly Arg Val Phe Pro Tyr Val Glu Gly Asp Lys
    1010                1015                1020                
Ser Phe Ala Glu Gly Gln Thr Ser Ile Asn Lys Thr Phe Lys Lys Ala
1025                1030                1035                1040
Leu Glu Glu Ala Ala Lys Arg Phe Gln Glu Leu Lys Ala Gln Arg Glu
                1045                1050                1055    
Ser Lys Glu Ala Leu Glu Ile Glu Lys Asn Ser Arg Lys Pro Pro Pro
            1060                1065                1070        
Tyr Lys His Ile Lys Ala Asn Lys Val Ile Gly Lys Val Gln Ile Gln
        1075                1080                1085            
Val Ala Asp Leu Ser Glu Ile Pro Arg Cys Asn Cys Lys Pro Ala Asp
    1090                1095                1100                
Glu Asn Pro Cys Gly Leu Glu Ser Glu Cys Leu Asn Arg Met Leu Gln
1105                1110                1115                1120
Tyr Glu Cys His Pro Gln Val Cys Pro Ala Gly Asp Arg Cys Gln Asn
                1125                1130                1135    
Gln Cys Phe Thr Lys Arg Leu Tyr Pro Asp Ala Glu Ile Ile Lys Thr
            1140                1145                1150        
Glu Arg Arg Gly Trp Gly Leu Arg Thr Lys Arg Ser Ile Lys Lys Gly
        1155                1160                1165            
Glu Phe Val Asn Glu Tyr Val Gly Glu Leu Ile Asp Glu Glu Glu Cys
    1170                1175                1180                
Arg Leu Arg Ile Lys Arg Ala His Glu Asn Ser Val Thr Asn Phe Tyr
1185                1190                1195                1200
Met Leu Thr Val Thr Lys Asp Arg Ile Ile Asp Ala Gly Pro Lys Gly
                1205                1210                1215    
Asn Tyr Ser Arg Phe Met Asn His Ser Cys Asn Pro Asn Cys Glu Thr
            1220                1225                1230        
Gln Lys Trp Thr Val Asn Gly Asp Val Arg Val Gly Leu Phe Ala Leu
        1235                1240                1245            
Cys Asp Ile Pro Ala Gly Met Glu Leu Thr Phe Asn Tyr Asn Leu Asp
    1250                1255                1260                
Cys Leu Gly Asn Gly Arg Thr Glu Cys His Cys Gly Ala Asp Asn Cys
1265                1270                1275                1280
Ser Gly Phe Leu Gly Val Arg Pro Lys Ser Ala Cys Ala Ser Thr Asn
                1285                1290                1295    
Glu Glu Lys Ala Lys Asn Ala Lys Leu Lys Gln Lys Arg Arg Lys Ile
            1300                1305                1310        
Lys Thr Glu Pro Lys Gln Met His Glu Asp Tyr Cys Phe Gln Cys Gly
        1315                1320                1325            
Asp Gly Gly Glu Leu Val Met Cys Asp Lys Lys Asp Cys Pro Lys Ala
    1330                1335                1340                
Tyr His Leu Leu Cys Leu Asn Leu Thr Gln Pro Pro Tyr Gly Lys Trp
1345                1350                1355                1360
Glu Cys Pro Trp His Gln Cys Asp Glu Cys Ser Ser Ala Ala Val Ser
                1365                1370                1375    
Phe Cys Glu Phe Cys Pro His Ser Phe Cys Lys Asp His Glu Lys Gly
            1380                1385                1390        
Ala Leu Val Pro Ser Ala Leu Glu Gly Arg Leu Cys Cys Ser Glu His
        1395                1400                1405            
Asp Pro Met Ala Pro Val Ser Pro Glu Tyr Trp Ser Lys Ile Lys Cys
    1410                1415                1420                
Lys Trp Glu Ser Gln Asp His Gly Glu Glu Val Lys Glu
1425                1430                1435        


<210> 1725
<211> 697
<212> PRT
<213> Homo sapiens

<400> 1725
Met Gly Glu Arg Ala Gly Ser Pro Gly Thr Asp Gln Glu Arg Lys Ala
 1               5                  10                  15      
Gly Lys His His Tyr Ser Tyr Leu Ser Asp Phe Glu Thr Pro Gln Ser
            20                  25                  30          
Ser Gly Arg Ser Ser Leu Val Ser Ser Ser Pro Ala Ser Val Arg Arg
        35                  40                  45              
Lys Asn Pro Lys Arg Gln Thr Ser Asp Gly Gln Val His His Gln Ala
    50                  55                  60                  
Pro Arg Lys Pro Ser Pro Lys Gly Leu Pro Asn Arg Lys Gly Val Arg
65                  70                  75                  80  
Val Gly Phe Arg Ser Gln Ser Leu Asn Arg Glu Pro Leu Arg Lys Asp
                85                  90                  95      
Thr Asp Leu Val Thr Lys Arg Ile Leu Ser Ala Arg Leu Leu Lys Ile
            100                 105                 110         
Asn Glu Leu Gln Asn Glu Val Ser Glu Leu Gln Val Lys Leu Ala Glu
        115                 120                 125             
Leu Leu Lys Glu Asn Lys Ser Leu Lys Arg Leu Gln Tyr Arg Gln Glu
    130                 135                 140                 
Lys Ala Leu Asn Lys Phe Glu Asp Ala Glu Asn Glu Ile Ser Gln Leu
145                 150                 155                 160 
Ile Phe Arg His Asn Asn Glu Ile Thr Ala Leu Lys Glu Arg Leu Arg
                165                 170                 175     
Lys Ser Gln Glu Lys Glu Arg Ala Thr Glu Lys Arg Val Lys Asp Thr
            180                 185                 190         
Glu Ser Glu Leu Phe Arg Thr Lys Phe Ser Leu Gln Lys Leu Lys Glu
        195                 200                 205             
Ile Ser Glu Ala Arg His Leu Pro Glu Arg Asp Asp Leu Ala Lys Lys
    210                 215                 220                 
Leu Val Ser Ala Glu Leu Lys Leu Asp Asp Thr Glu Arg Arg Ile Lys
225                 230                 235                 240 
Glu Leu Ser Lys Asn Leu Glu Leu Ser Thr Asn Ser Phe Gln Arg Gln
                245                 250                 255     
Leu Leu Ala Glu Arg Lys Arg Ala Tyr Glu Ala His Asp Glu Asn Lys
            260                 265                 270         
Val Leu Gln Lys Glu Val Gln Arg Leu Tyr His Lys Leu Lys Glu Lys
        275                 280                 285             
Glu Arg Glu Leu Asp Ile Lys Asn Ile Tyr Ser Asn Arg Leu Pro Lys
    290                 295                 300                 
Ser Ser Pro Asn Lys Glu Lys Glu Leu Ala Leu Arg Lys Asn Ala Ala
305                 310                 315                 320 
Cys Gln Ser Asp Phe Ala Asp Leu Cys Thr Lys Gly Val Gln Thr Met
                325                 330                 335     
Glu Asp Phe Lys Pro Glu Glu Tyr Pro Leu Thr Pro Glu Thr Ile Met
            340                 345                 350         
Cys Tyr Glu Asn Lys Trp Glu Glu Pro Gly His Leu Thr Leu Asp Leu
        355                 360                 365             
Gln Ser Gln Lys Gln Asp Arg His Gly Glu Ala Gly Ile Leu Asn Pro
    370                 375                 380                 
Ile Met Glu Arg Glu Glu Lys Phe Val Thr Asp Glu Glu Leu His Val
385                 390                 395                 400 
Val Lys Gln Glu Val Glu Lys Leu Glu Asp Glu Trp Glu Arg Glu Glu
                405                 410                 415     
Leu Asp Lys Lys Gln Lys Glu Lys Ala Ser Leu Leu Glu Arg Glu Glu
            420                 425                 430         
Lys Pro Glu Trp Glu Thr Gly Arg Tyr Gln Leu Gly Met Tyr Pro Ile
        435                 440                 445             
Gln Asn Met Asp Lys Leu Gln Gly Glu Glu Glu Glu Arg Leu Lys Arg
    450                 455                 460                 
Glu Met Leu Leu Ala Lys Leu Asn Glu Ile Asp Arg Glu Leu Gln Asp
465                 470                 475                 480 
Ser Arg Asn Leu Lys Tyr Pro Val Leu Pro Leu Leu Pro Asp Phe Glu
                485                 490                 495     
Ser Lys Leu His Ser Pro Glu Arg Ser Pro Lys Thr Tyr Arg Phe Ser
            500                 505                 510         
Glu Ser Ser Glu Arg Leu Phe Asn Gly His His Leu Gln Asp Ile Ser
        515                 520                 525             
Phe Ser Thr Pro Lys Gly Glu Gly Gln Asn Ser Gly Asn Val Arg Ser
    530                 535                 540                 
Pro Ala Ser Pro Asn Glu Phe Ala Phe Gly Ser Tyr Val Pro Ser Phe
545                 550                 555                 560 
Ala Lys Thr Ser Glu Arg Ser Asn Pro Phe Ser Gln Lys Ser Ser Phe
                565                 570                 575     
Leu Asp Phe Gln Arg Asn Ser Met Glu Lys Leu Ser Lys Asp Gly Val
            580                 585                 590         
Asp Leu Ile Thr Arg Lys Glu Lys Lys Ala Asn Leu Met Glu Gln Leu
        595                 600                 605             
Phe Gly Ala Ser Gly Ser Ser Thr Ile Ser Ser Lys Ser Ser Asp Pro
    610                 615                 620                 
Asn Ser Val Ala Ser Ser Lys Gly Asp Ile Asp Pro Leu Asn Phe Leu
625                 630                 635                 640 
Pro Gly Asn Lys Gly Ser Arg Asp Gln Glu His Asp Glu Asp Glu Gly
                645                 650                 655     
Phe Phe Leu Ser Glu Gly Arg Ser Phe Asn Pro Asn Arg His Arg Leu
            660                 665                 670         
Lys His Ala Asp Asp Lys Pro Ala Val Lys Ala Ala Asp Ser Val Glu
        675                 680                 685             
Asp Glu Ile Glu Glu Val Ala Leu Arg
    690                 695         


<210> 1726
<211> 565
<212> PRT
<213> Homo sapiens

<400> 1726
Gly Lys Asn Val Asp Asn Asn Lys Arg Ile Ser Thr Gly Lys Lys Met
 1               5                  10                  15      
Ser Gln Thr Ser Leu Lys Gln Lys Lys Asn Glu Pro Gly Met Arg Ser
            20                  25                  30          
Ser Lys Glu Ser Leu Glu Ala Glu Lys Arg Lys Glu Ser Asp Lys Thr
        35                  40                  45              
Gly Val Arg Leu Ser Asn Gln Gly Ser Gln Glu Ser Ser Leu Arg Lys
    50                  55                  60                  
Thr Asp Ser Arg Gly Tyr Leu Val Arg Ser Gln Trp Ser Arg Ile Ser
65                  70                  75                  80  
Arg Ser Pro Ser Thr Lys Ala Pro Ser Ile Asp Glu Pro Arg Ser Arg
                85                  90                  95      
Asn Thr Ser Ala Lys Leu Pro Ser Ser Ser Thr Ser Ser Arg Thr Pro
            100                 105                 110         
Ser Thr Ser Pro Ser Leu His Asp Ser Ser Pro Pro Pro Leu Ser Gly
        115                 120                 125             
Gln Pro Ser Leu Gln Pro Pro Ala Ser Pro Gln Leu Pro Arg Ser Leu
    130                 135                 140                 
Asp Ser Arg Pro Pro Thr Pro Pro Glu Pro Asp Pro Gly Ser Arg Arg
145                 150                 155                 160 
Ser Thr Lys Met Gln Glu Asn Pro Glu Ala Trp Ala Gln Gly Ile Val
                165                 170                 175     
Arg Glu Ile Arg Gln Thr Arg Asp Ser Gln Pro Leu Glu Tyr Ser Arg
            180                 185                 190         
Thr Ser Pro Thr Glu Trp Lys Ser Ser Ser Gln Arg Arg Gly Ile Tyr
        195                 200                 205             
Pro Ala Ser Thr Gln Leu Asp Arg Asn Ser Leu Ser Glu Gln Gln Gln
    210                 215                 220                 
Gln Gln Arg Glu Asp Glu Asp Asp Tyr Glu Ala Ala Tyr Trp Ala Ser
225                 230                 235                 240 
Met Lys Ser Phe Tyr Glu Lys Asn Pro Ser Cys Trp Arg Pro Trp Pro
                245                 250                 255     
Pro Lys Pro Lys Asn Ala Ile Thr Ile Ala Leu Ser Ser Cys Ala Leu
            260                 265                 270         
Phe Asn Met Val Asp Gly Arg Lys Ile Tyr Glu Gln Glu Gly Leu Glu
        275                 280                 285             
Lys Tyr Met Glu Tyr Gln Leu Thr Asn Glu Asn Val Ile Leu Thr Pro
    290                 295                 300                 
Gly Pro Ala Phe Arg Phe Val Lys Ala Leu Gln Tyr Val Asn Ala Arg
305                 310                 315                 320 
Leu Arg Asp Leu Tyr Pro Asp Glu Gln Asp Leu Phe Asp Ile Val Leu
                325                 330                 335     
Met Thr Asn Asn His Ala Gln Val Gly Val Arg Leu Ile Asn Ser Val
            340                 345                 350         
Asn His Tyr Gly Leu Leu Ile Asp Arg Phe Cys Leu Thr Gly Gly Lys
        355                 360                 365             
Asp Pro Ile Gly Tyr Leu Lys Ala Tyr Leu Thr Asn Leu Tyr Ile Ala
    370                 375                 380                 
Ala Asp Ser Glu Lys Val Gln Glu Ala Ile Gln Glu Gly Ile Ala Ser
385                 390                 395                 400 
Ala Thr Met Phe Asp Gly Ala Lys Asp Met Ala Tyr Cys Asp Thr Gln
                405                 410                 415     
Leu Arg Val Ala Phe Asp Gly Asp Ala Val Leu Phe Ser Asp Glu Ser
            420                 425                 430         
Glu His Phe Thr Lys Glu His Gly Leu Asp Lys Phe Phe Gln Tyr Asp
        435                 440                 445             
Thr Leu Cys Glu Ser Lys Pro Leu Ala Gln Gly Pro Leu Lys Gly Phe
    450                 455                 460                 
Leu Glu Asp Leu Gly Arg Leu Gln Lys Lys Phe Tyr Ala Lys Asn Glu
465                 470                 475                 480 
Arg Leu Leu Cys Pro Ile Arg Thr Tyr Leu Val Thr Ala Arg Ser Ala
                485                 490                 495     
Ala Ser Ser Gly Ala Arg Val Leu Lys Thr Phe Arg Arg Trp Gly Leu
            500                 505                 510         
Glu Ile Asp Glu Ala Leu Phe Leu Ala Gly Ala Pro Lys Ser Pro Ile
        515                 520                 525             
Leu Val Lys Ile Arg Pro His Ile Phe Phe Asp Asp His Met Phe His
    530                 535                 540                 
Ile Glu Gly Ala Gln Arg Leu Gly Ser Ile Ala Ala Tyr Gly Phe Asn
545                 550                 555                 560 
Lys Lys Phe Ser Ser
                565 


<210> 1727
<211> 614
<212> PRT
<213> Homo sapiens

<400> 1727
Met Gly Gly Ser Ser Pro Val Thr Ser Lys Ala Ile Val Asp Ala Asp
 1               5                  10                  15      
Gly Arg Ile Tyr Ile Arg Asn Trp Gln Gly Gly Ile Leu Ser Gly Gly
            20                  25                  30          
Phe Glu Lys Asn Pro Lys Pro Ile Phe Thr Glu Gly Lys Asn Gln Leu
        35                  40                  45              
Glu Ile Gln Asn Leu Gln Glu Asp Trp Asp His Phe Glu Pro Leu Leu
    50                  55                  60                  
Ser Ser Leu Leu Arg Arg Met Pro Glu Leu Glu Thr Leu Glu Ile Met
65                  70                  75                  80  
Lys Leu Val Asn Cys Pro Glu Thr Phe Thr Pro Asp Met Arg Cys Ile
                85                  90                  95      
Met Gly Glu Ser Pro Ala Val Gln Gly Tyr Phe Val Leu Ala Gly Met
            100                 105                 110         
Asn Ser Ala Gly Leu Ser Phe Gly Gly Gly Ala Gly Lys Tyr Leu Ala
        115                 120                 125             
Glu Trp Met Val His Gly Tyr Pro Ser Glu Asn Val Trp Glu Leu Asp
    130                 135                 140                 
Leu Lys Arg Phe Gly Ala Leu Gln Ser Ser Arg Thr Phe Leu Arg His
145                 150                 155                 160 
Arg Ala Ile Glu Val Met Pro Leu Met Tyr Asp Leu Lys Val Pro Arg
                165                 170                 175     
Trp Asp Phe Gln Thr Gly Arg Gln Leu Arg Thr Ser Pro Leu Tyr Asp
            180                 185                 190         
Arg Leu Asp Ala Gln Gly Ala Arg Trp Met Glu Lys His Gly Phe Glu
        195                 200                 205             
Arg Pro Lys Tyr Phe Val Pro Pro Asp Lys Asp Leu Leu Ala Leu Glu
    210                 215                 220                 
Gln Ser Lys Thr Phe Tyr Lys Pro Asp Trp Phe Asp Ile Val Glu Ser
225                 230                 235                 240 
Glu Val Lys Cys Cys Lys Glu Ala Val Cys Val Ile Asp Met Ser Ser
                245                 250                 255     
Phe Thr Lys Phe Glu Ile Thr Ser Thr Gly Asp Gln Ala Leu Glu Val
            260                 265                 270         
Leu Gln Tyr Leu Phe Ser Ser Asp Leu Asp Val Pro Val Gly His Ile
        275                 280                 285             
Val His Thr Gly Met Leu Asn Glu Gly Gly Gly Tyr Glu Asn Asp Cys
    290                 295                 300                 
Ser Ile Ala Arg Leu Asn Lys Arg Ser Phe Phe Met Ile Ser Pro Thr
305                 310                 315                 320 
Asp Gln Gln Val His Cys Trp Ala Trp Leu Lys Lys His Met Pro Lys
                325                 330                 335     
Asp Ser Asn Leu Leu Leu Glu Asp Val Thr Trp Lys Tyr Thr Ala Leu
            340                 345                 350         
Asn Leu Ile Gly Pro Arg Ala Val Asp Val Leu Ser Glu Leu Ser Tyr
        355                 360                 365             
Ala Pro Met Thr Pro Asp His Phe Pro Ser Leu Phe Cys Lys Glu Met
    370                 375                 380                 
Ser Val Gly Tyr Ala Lys Gly Ile Arg Val Met Ser Met Thr His Thr
385                 390                 395                 400 
Gly Glu Pro Gly Phe Met Leu Tyr Ile Pro Ile Glu Gly Met Asp Phe
                405                 410                 415     
Ile Gly Arg Asp Ala Leu Leu Gln Gln Lys Gln Asn Gly Val Tyr Lys
            420                 425                 430         
Arg Leu Thr Met Phe Ile Leu Asp Asp His Asp Ser Asp Leu Asp Leu
        435                 440                 445             
Trp Pro Trp Trp Gly Glu Pro Ile Tyr Arg Asn Gly Gln Tyr Val Gly
    450                 455                 460                 
Lys Thr Thr Ser Ser Ala Tyr Ser Tyr Ser Leu Glu Arg His Val Cys
465                 470                 475                 480 
Leu Gly Phe Val His Asn Phe Ser Glu Asp Thr Gly Glu Glu Gln Val
                485                 490                 495     
Val Thr Ala Asp Phe Ile Asn Arg Gly Glu Tyr Glu Ile Asp Ile Ala
            500                 505                 510         
Gly Tyr Arg Phe Gln Ala Lys Ala Lys Leu Tyr Pro Val Ala Ser Leu
        515                 520                 525             
Phe Thr Gln Lys Arg Arg Lys Asp Asp Met Glu Leu Ser Asp Phe Leu
    530                 535                 540                 
Ala Leu Pro Pro Pro Pro Pro Asn Ile His Ser Gly Leu Phe Phe Pro
545                 550                 555                 560 
Ser His Pro Ser Leu Ser Cys Ser Trp Trp Gln Glu Val Cys Leu Thr
                565                 570                 575     
Gly Gln Lys Gln Ala Pro His His Leu Val Leu Glu Trp Ala Ser Pro
            580                 585                 590         
Trp Ser Phe Ser Ser Phe Arg Leu Cys Ser Ser Ser Gly Ala Phe Ala
        595                 600                 605             
Ser His Leu Leu Ser Pro
    610                 


<210> 1728
<211> 151
<212> PRT
<213> Homo sapiens

<400> 1728
Met Leu Gln Arg Leu Gln Ile Ile Gly Glu Ser Ile Met Lys Arg Asp
 1               5                  10                  15      
Leu Thr Ser Val Ile Asn Val Ala Asn Phe Ser Glu Ile Val His Ile
            20                  25                  30          
Leu Gln Val Ile Gly Glu Leu Ile Leu Glu Arg Asn Leu Thr Asn Val
        35                  40                  45              
Met Thr Val Pro Arg Ser Ser Val Lys Leu His Pro Met Gln Asn Ile
    50                  55                  60                  
Gly Glu Phe Ile Gln Glu Arg Asn Leu Thr Ser Val Met Ile Val Ala
65                  70                  75                  80  
Lys Pro Leu Leu His Val His Thr Ser Leu Asp Ile Arg Glu Ser Ile
                85                  90                  95      
Leu Asp Arg Asn Leu Thr Asn Val Ile Ser Val Ala Arg Ser Ser Val
            100                 105                 110         
Gln Asp His Ser Met Gln Asn Ile Arg Lys Phe Ile Phe Glu Ile Thr
        115                 120                 125             
Val Pro Asn Glu Met Ser Ile Ala Asn His Gln Ala Leu Ile Asp Ile
    130                 135                 140                 
Gly Val Asn Ser Ala Leu Thr
145                 150     


<210> 1729
<211> 653
<212> PRT
<213> Homo sapiens

<400> 1729
Met Ala Ala Glu Ala Ser Lys Thr Gly Pro Ser Arg Ser Ser Tyr Gln
 1               5                  10                  15      
Arg Met Gly Arg Lys Ser Gln Pro Trp Gly Ala Ala Glu Ile Gln Cys
            20                  25                  30          
Thr Arg Cys Gly Arg Arg Val Ser Arg Ser Ser Gly His His Cys Glu
        35                  40                  45              
Leu Gln Cys Gly His Ala Phe Cys Glu Leu Cys Leu Leu Met Thr Glu
    50                  55                  60                  
Glu Cys Thr Thr Ile Ile Cys Pro Asp Cys Glu Val Ala Thr Ala Val
65                  70                  75                  80  
Asn Thr Arg Gln Arg Tyr Tyr Pro Met Ala Gly Tyr Ile Lys Glu Asp
                85                  90                  95      
Ser Ile Met Glu Lys Leu Gln Pro Lys Thr Ile Lys Asn Cys Ser Gln
            100                 105                 110         
Asp Phe Lys Lys Thr Ala Asp Gln Leu Thr Thr Gly Leu Glu Arg Ser
        115                 120                 125             
Ala Ser Thr Asp Lys Thr Leu Leu Asn Ser Ser Ala Val Met Leu Asp
    130                 135                 140                 
Thr Asn Thr Ala Glu Glu Ile Asp Glu Ala Leu Asn Thr Ala His His
145                 150                 155                 160 
Ser Phe Glu Gln Leu Ser Ile Ala Gly Lys Ala Leu Glu His Met Gln
                165                 170                 175     
Lys Gln Thr Ile Glu Glu Arg Glu Arg Val Ile Glu Val Val Glu Lys
            180                 185                 190         
Gln Phe Asp Gln Leu Leu Ala Phe Phe Asp Ser Arg Lys Lys Asn Leu
        195                 200                 205             
Cys Glu Glu Phe Ala Arg Thr Thr Asp Asp Tyr Leu Ser Asn Leu Ile
    210                 215                 220                 
Lys Ala Lys Ser Tyr Ile Glu Glu Lys Lys Asn Asn Leu Asn Ala Ala
225                 230                 235                 240 
Met Asn Ile Ala Arg Ala Leu Gln Leu Ser Pro Ser Leu Arg Thr Tyr
                245                 250                 255     
Cys Asp Leu Asn Gln Ile Ile Arg Thr Leu Gln Leu Thr Ser Asp Ser
            260                 265                 270         
Glu Leu Ala Gln Val Ser Ser Pro Gln Leu Arg Asn Pro Pro Arg Leu
        275                 280                 285             
Ser Val Asn Cys Ser Glu Ile Ile Cys Met Phe Asn Asn Met Gly Lys
    290                 295                 300                 
Ile Glu Phe Arg Asp Ser Thr Lys Cys Tyr Pro Gln Glu Asn Glu Ile
305                 310                 315                 320 
Arg Gln Asn Val Gln Lys Lys Tyr Asn Asn Lys Lys Glu Leu Ser Cys
                325                 330                 335     
Tyr Asp Thr Tyr Pro Pro Leu Glu Lys Lys Lys Val Asp Met Ser Val
            340                 345                 350         
Leu Thr Ser Glu Ala Pro Pro Pro Ser Leu Gln Pro Glu Thr Asn Asp
        355                 360                 365             
Val His Leu Glu Ala Lys Asn Phe Gln Pro Gln Lys Asp Val Ala Thr
    370                 375                 380                 
Ala Ser Pro Lys Thr Ile Ala Val Leu Pro Gln Met Gly Ser Ser Pro
385                 390                 395                 400 
Asp Val Ile Ile Glu Glu Ile Ile Glu Asp Asn Val Glu Ser Ser Ala
                405                 410                 415     
Glu Leu Val Phe Val Ser His Val Ile Asp Pro Cys His Phe Tyr Ile
            420                 425                 430         
Arg Lys Tyr Ser Gln Ile Lys Asp Ala Lys Val Leu Glu Lys Lys Val
        435                 440                 445             
Asn Glu Phe Cys Asn Arg Ser Ser His Leu Asp Pro Ser Asp Ile Leu
    450                 455                 460                 
Glu Leu Gly Ala Arg Ile Phe Val Ser Ser Ile Lys Asn Gly Met Trp
465                 470                 475                 480 
Cys Arg Gly Thr Ile Thr Glu Leu Ile Pro Ile Glu Gly Arg Asn Thr
                485                 490                 495     
Arg Lys Pro Cys Ser Pro Thr Arg Leu Phe Val His Glu Val Ala Leu
            500                 505                 510         
Ile Gln Ile Phe Met Val Asp Phe Gly Asn Ser Glu Val Leu Ile Val
        515                 520                 525             
Thr Gly Val Val Asp Thr His Val Arg Pro Glu His Ser Ala Lys Gln
    530                 535                 540                 
His Ile Ala Leu Asn Asp Leu Cys Leu Val Leu Arg Lys Ser Glu Pro
545                 550                 555                 560 
Tyr Thr Glu Gly Leu Leu Lys Asp Ile Gln Pro Leu Ala Gln Pro Cys
                565                 570                 575     
Ser Leu Lys Asp Ile Val Pro Gln Asn Ser Asn Glu Gly Trp Glu Glu
            580                 585                 590         
Glu Ala Lys Val Glu Phe Leu Lys Met Val Asn Asn Lys Ala Val Ser
        595                 600                 605             
Met Lys Val Phe Arg Glu Glu Asp Gly Val Leu Ile Val Asp Leu Gln
    610                 615                 620                 
Lys Pro Pro Pro Asn Lys Ile Ser Ser Asp Met Pro Val Ser Leu Arg
625                 630                 635                 640 
Asp Ala Leu Val Phe Met Glu Leu Ala Lys Asp Leu Ile
                645                 650             


<210> 1730
<211> 315
<212> PRT
<213> Homo sapiens

<400> 1730
Met His Arg Glu Pro Ala Lys Lys Lys Ala Glu Lys Arg Leu Phe Asp
 1               5                  10                  15      
Ala Ser Ser Phe Gly Lys Asp Leu Leu Ala Gly Gly Val Ala Ala Ala
            20                  25                  30          
Val Ser Lys Thr Ala Val Ala Pro Ile Glu Arg Val Lys Leu Leu Leu
        35                  40                  45              
Gln Val Gln Ala Ser Ser Lys Gln Ile Ser Pro Glu Ala Arg Tyr Lys
    50                  55                  60                  
Gly Met Val Asp Cys Leu Val Arg Ile Pro Arg Glu Gln Gly Phe Phe
65                  70                  75                  80  
Ser Phe Trp Arg Gly Asn Leu Ala Asn Val Ile Arg Tyr Phe Pro Thr
                85                  90                  95      
Gln Ala Leu Asn Phe Ala Phe Lys Asp Lys Tyr Lys Gln Leu Phe Met
            100                 105                 110         
Ser Gly Val Asn Lys Glu Lys Gln Phe Trp Arg Trp Phe Leu Ala Asn
        115                 120                 125             
Leu Ala Ser Gly Gly Ala Ala Gly Ala Thr Ser Leu Cys Val Val Tyr
    130                 135                 140                 
Pro Leu Asp Phe Ala Arg Thr Arg Leu Gly Val Asp Ile Gly Lys Gly
145                 150                 155                 160 
Pro Glu Glu Arg Gln Phe Lys Gly Leu Gly Asp Cys Ile Met Lys Ile
                165                 170                 175     
Ala Lys Ser Asp Gly Ile Ala Gly Leu Tyr Gln Gly Phe Gly Val Ser
            180                 185                 190         
Val Gln Gly Ile Ile Val Tyr Arg Ala Ser Tyr Phe Gly Ala Tyr Asp
        195                 200                 205             
Thr Val Lys Gly Leu Leu Pro Lys Pro Lys Lys Thr Pro Phe Leu Val
    210                 215                 220                 
Ser Phe Phe Ile Ala Gln Val Val Thr Thr Cys Ser Gly Ile Leu Ser
225                 230                 235                 240 
Tyr Pro Phe Asp Thr Val Arg Arg Arg Met Met Met Gln Ser Gly Glu
                245                 250                 255     
Ala Lys Arg Gln Tyr Lys Gly Thr Leu Asp Cys Phe Val Lys Ile Tyr
            260                 265                 270         
Gln His Glu Gly Ile Ser Ser Phe Phe Arg Gly Ala Phe Ser Asn Val
        275                 280                 285             
Leu Arg Gly Thr Gly Gly Ala Leu Val Leu Val Leu Tyr Asp Lys Ile
    290                 295                 300                 
Lys Glu Phe Phe His Ile Asp Ile Gly Gly Arg
305                 310                 315 


<210> 1731
<211> 701
<212> PRT
<213> Homo sapiens

<400> 1731
Met Glu Glu Asp Thr Asp Tyr Arg Ile Arg Phe Ser Ser Leu Cys Phe
 1               5                  10                  15      
Phe Asn Asp His Val Gly Phe His Gly Thr Ile Lys Ser Ser Pro Ser
            20                  25                  30          
Asp Phe Ile Val Ile Glu Ile Asp Glu Gln Gly Gln Leu Val Asn Lys
        35                  40                  45              
Thr Ile Asp Glu Pro Ile Phe Lys Ile Ser Glu Ile Gln Leu Glu Pro
    50                  55                  60                  
Asn Asn Phe Pro Lys Lys Pro Lys Leu Asp Leu Gln Asn Leu Ser Leu
65                  70                  75                  80  
Glu Asp Gly Arg Asn Gln Glu Val His Thr Leu Ile Lys Tyr Thr Asp
                85                  90                  95      
Gly Asp Gln Asn His Gln Ser Gly Ser Glu Lys Glu Asp Thr Ile Val
            100                 105                 110         
Asp Gly Thr Ser Lys Cys Glu Glu Lys Ala Asp Val Leu Ser Ser Phe
        115                 120                 125             
Leu Asp Glu Lys Thr His Glu Leu Leu Asn Asn Phe Ala Cys Asp Val
    130                 135                 140                 
Arg Glu Lys Trp Leu Ser Lys Thr Glu Leu Ile Gly Leu Pro Pro Glu
145                 150                 155                 160 
Phe Ser Ile Gly Arg Ile Leu Asp Lys Asn Gln Arg Ala Ser Leu His
                165                 170                 175     
Ser Ala Ile Arg Gln Lys Phe Pro Phe Leu Val Thr Val Gly Lys Asn
            180                 185                 190         
Ser Glu Ile Val Val Lys Pro Asn Leu Glu Tyr Lys Glu Leu Cys His
        195                 200                 205             
Leu Val Ser Glu Glu Glu Ala Phe Asp Phe Phe Lys Tyr Leu Asp Ala
    210                 215                 220                 
Lys Lys Glu Asn Ser Lys Phe Thr Phe Lys Pro Asp Thr Asn Lys Asp
225                 230                 235                 240 
His Arg Lys Ala Val His His Phe Val Asn Lys Lys Phe Gly Asn Leu
                245                 250                 255     
Val Glu Thr Lys Ser Phe Ser Lys Met Asn Cys Ser Ala Gly Asn Pro
            260                 265                 270         
Asn Val Val Val Thr Val Arg Phe Arg Glu Lys Ala His Lys Arg Gly
        275                 280                 285             
Lys Arg Pro Leu Ser Glu Cys Gln Glu Gly Lys Val Ile Tyr Thr Ala
    290                 295                 300                 
Phe Thr Leu Arg Lys Glu Asn Leu Glu Met Phe Glu Ala Ile Gly Phe
305                 310                 315                 320 
Leu Ala Ile Lys Leu Gly Val Ile Pro Ser Asp Phe Ser Tyr Ala Gly
                325                 330                 335     
Leu Lys Asp Lys Lys Ala Ile Thr Tyr Gln Ala Met Val Val Arg Lys
            340                 345                 350         
Val Thr Pro Glu Arg Leu Lys Asn Ile Glu Lys Glu Ile Glu Lys Lys
        355                 360                 365             
Arg Met Asn Val Phe Asn Ile Arg Ser Val Asp Asp Ser Leu Arg Leu
    370                 375                 380                 
Gly Gln Leu Lys Gly Asn His Phe Asp Ile Val Ile Arg Asn Leu Lys
385                 390                 395                 400 
Lys Gln Ile Asn Asp Ser Ala Asn Leu Arg Glu Arg Ile Met Glu Ala
                405                 410                 415     
Ile Glu Asn Val Lys Lys Lys Gly Phe Val Asn Tyr Tyr Gly Pro Gln
            420                 425                 430         
Arg Phe Gly Lys Gly Arg Lys Val His Thr Asp Gln Ile Gly Leu Ala
        435                 440                 445             
Leu Leu Lys Asn Glu Met Met Lys Ala Ile Lys Leu Phe Leu Thr Pro
    450                 455                 460                 
Glu Asp Leu Asp Asp Pro Val Asn Arg Ala Lys Lys Tyr Phe Leu Gln
465                 470                 475                 480 
Thr Glu Asp Ala Lys Gly Thr Leu Ser Leu Met Pro Glu Phe Lys Val
                485                 490                 495     
Arg Glu Arg Ala Leu Leu Glu Ala Leu His Arg Phe Gly Met Thr Glu
            500                 505                 510         
Glu Gly Cys Ile Gln Ala Trp Phe Ser Leu Pro His Ser Met Arg Ile
        515                 520                 525             
Phe Tyr Val His Ala Tyr Thr Ser Lys Ile Trp Asn Glu Ala Val Ser
    530                 535                 540                 
Tyr Arg Leu Glu Thr Tyr Gly Ala Arg Val Val Gln Gly Asp Leu Val
545                 550                 555                 560 
Cys Leu Asp Glu Asp Ile Asp Asp Glu Asn Phe Pro Asn Ser Lys Ile
                565                 570                 575     
His Leu Val Thr Glu Glu Glu Gly Ser Ala Asn Met Tyr Ala Ile His
            580                 585                 590         
Gln Val Val Leu Pro Val Leu Gly Tyr Asn Ile Gln Tyr Pro Lys Asn
        595                 600                 605             
Lys Val Gly Gln Trp Tyr His Asp Ile Leu Ser Arg Asp Gly Leu Gln
    610                 615                 620                 
Thr Cys Arg Phe Lys Val Pro Thr Leu Lys Leu Asn Ile Pro Gly Cys
625                 630                 635                 640 
Tyr Arg Gln Ile Leu Lys His Pro Cys Asn Leu Ser Tyr Gln Leu Met
                645                 650                 655     
Glu Asp His Asp Ile Asp Val Lys Thr Lys Gly Ser His Ile Asp Glu
            660                 665                 670         
Thr Ala Leu Ser Leu Leu Ile Ser Phe Asp Leu Asp Ala Ser Cys Tyr
        675                 680                 685             
Ala Thr Val Cys Leu Lys Glu Ile Met Lys His Asp Val
    690                 695                 700     


<210> 1732
<211> 132
<212> PRT
<213> Homo sapiens

<400> 1732
Met Arg Ala Ile Asn Ile Ala Asp Glu Leu Pro Arg Ser Arg Ala Arg
 1               5                  10                  15      
Lys Leu Ala Asp Glu Gln Leu Ser Ser Val Ile Gln Asp Met Ala Val
            20                  25                  30          
Arg Gln His Leu Leu Thr Asn Leu Val Glu Val Asp Gly Arg Phe Val
        35                  40                  45              
Trp Arg Val Asn Leu Asp Ala Leu Thr Gln His Leu Asp Lys Ile Leu
    50                  55                  60                  
Ala Phe Pro Gln Arg Gln Glu Ser Tyr Leu Gly Pro Thr Leu Phe Leu
65                  70                  75                  80  
Leu Gly Gly Asn Ser Gln Phe Val His Pro Ser His His Pro Glu Ile
                85                  90                  95      
Met Arg Leu Phe Pro Arg Ala Gln Met Gln Thr Val Pro Asn Ala Gly
            100                 105                 110         
His Trp Ile His Ala Asp Arg Pro Gln Asp Phe Ile Ala Ala Ile Arg
        115                 120                 125             
Gly Phe Leu Val
    130         


<210> 1733
<211> 580
<212> PRT
<213> Homo sapiens

<400> 1733
Met Phe Val Pro Arg Ser Leu Lys Ile Lys Arg Asn Ala Asn Asp Asp
 1               5                  10                  15      
Gly Lys Ser Cys Val Ala Lys Ile Ile Lys Pro Asp Pro Glu Asp Leu
            20                  25                  30          
Gln Leu Asp Lys Ser Arg Asp Val Pro Val Asp Ala Val Ala Thr Glu
        35                  40                  45              
Ala Ala Thr Ile Asp Arg His Ile Ser Glu Ser Cys Pro Phe Pro Ser
    50                  55                  60                  
Pro Gly Gly Gln Leu Ala Glu Val His Ser Val Ser Pro Glu Gln Gly
65                  70                  75                  80  
Ala Lys Asp Ser His Pro Ser Glu Glu Pro Val Lys Ser Phe Ser Lys
                85                  90                  95      
Thr Gln Arg Trp Ala Glu Pro Gly Glu Pro Ile Cys Val Val Cys Gly
            100                 105                 110         
Arg Tyr Gly Glu Tyr Ile Cys Asp Lys Thr Asp Glu Asp Val Cys Ser
        115                 120                 125             
Leu Glu Cys Lys Ala Lys His Leu Leu Gln Val Lys Glu Lys Glu Glu
    130                 135                 140                 
Lys Ser Lys Leu Ser Asn Pro Gln Lys Ala Asp Ser Glu Pro Glu Ser
145                 150                 155                 160 
Pro Leu Asn Ala Ser Tyr Val Tyr Lys Glu His Pro Phe Ile Leu Asn
                165                 170                 175     
Leu Gln Glu Asp Gln Ile Glu Asn Leu Lys Gln Gln Leu Gly Ile Leu
            180                 185                 190         
Val Gln Gly Gln Glu Val Thr Arg Pro Ile Ile Asp Phe Glu His Cys
        195                 200                 205             
Ser Leu Pro Glu Val Leu Asn His Asn Leu Lys Lys Ser Gly Tyr Glu
    210                 215                 220                 
Val Pro Thr Pro Ile Gln Met Gln Met Ile Pro Val Gly Leu Leu Gly
225                 230                 235                 240 
Arg Asp Ile Leu Ala Ser Ala Asp Thr Gly Ser Gly Lys Thr Ala Ala
                245                 250                 255     
Phe Leu Leu Pro Val Ile Met Arg Ala Leu Phe Glu Ser Lys Thr Pro
            260                 265                 270         
Ser Ala Leu Ile Leu Thr Pro Thr Arg Glu Leu Ala Ile Gln Ile Glu
        275                 280                 285             
Arg Gln Ala Lys Glu Leu Met Ser Gly Leu Pro Arg Met Lys Thr Val
    290                 295                 300                 
Leu Leu Val Gly Gly Leu Pro Leu Pro Pro Gln Leu Tyr Arg Leu Gln
305                 310                 315                 320 
Gln His Val Lys Val Ile Ile Ala Thr Pro Gly Arg Leu Leu Asp Ile
                325                 330                 335     
Ile Lys Gln Ser Ser Val Glu Leu Cys Gly Val Lys Ile Val Val Val
            340                 345                 350         
Asp Glu Ala Asp Thr Met Leu Lys Met Gly Phe Gln Gln Gln Val Leu
        355                 360                 365             
Asp Ile Leu Glu Asn Ile Pro Asn Asp Cys Gln Thr Ile Leu Val Ser
    370                 375                 380                 
Ala Thr Ile Pro Thr Ser Ile Glu Gln Leu Ala Ser Gln Leu Leu His
385                 390                 395                 400 
Asn Pro Val Arg Ile Ile Thr Gly Glu Lys Asn Leu Pro Cys Ala Asn
                405                 410                 415     
Val Arg Gln Ile Ile Leu Trp Val Glu Asp Pro Ala Lys Lys Lys Lys
            420                 425                 430         
Leu Phe Glu Ile Leu Asn Asp Lys Lys Leu Phe Lys Pro Pro Val Leu
        435                 440                 445             
Val Phe Val Asp Cys Lys Leu Gly Ala Asp Leu Leu Ser Glu Ala Val
    450                 455                 460                 
Gln Lys Ile Thr Gly Leu Lys Ser Ile Ser Ile His Ser Glu Lys Ser
465                 470                 475                 480 
Gln Ile Glu Arg Lys Asn Ile Leu Lys Gly Leu Leu Glu Gly Asp Tyr
                485                 490                 495     
Glu Val Val Val Ser Thr Gly Val Leu Gly Arg Gly Leu Asp Leu Ile
            500                 505                 510         
Ser Val Arg Leu Val Val Asn Phe Asp Met Pro Ser Ser Met Asp Glu
        515                 520                 525             
Tyr Val His Gln Glu Asn Thr Tyr Lys Ser Thr Trp Arg Asn Pro Gln
    530                 535                 540                 
His Phe Gln Gln Asp Val Arg Met Thr Leu Gly Tyr Val Gly Lys Ala
545                 550                 555                 560 
Gln Trp Glu Glu Asp Asn Gln Leu Lys Val Lys Leu Gly Leu Lys Lys
                565                 570                 575     
Asn Cys Ser Ser
            580 


<210> 1734
<211> 526
<212> PRT
<213> Homo sapiens

<400> 1734
Pro Val Glu Glu Glu Asp Val Gly Ser Ser Glu Lys Leu Gly Arg Glu
 1               5                  10                  15      
Thr Glu Glu Gln Asp Ser Asp Ser Ala Glu Gln Gly Asp Pro Ala Gly
            20                  25                  30          
Glu Gly Lys Glu Val Leu Cys Asp Phe Cys Leu Asp Asp Thr Arg Arg
        35                  40                  45              
Val Lys Ala Val Lys Ser Cys Leu Thr Cys Met Val Asn Tyr Cys Glu
    50                  55                  60                  
Glu His Leu Gln Pro His Gln Val Asn Ile Lys Leu Gln Ser His Leu
65                  70                  75                  80  
Leu Thr Glu Pro Val Lys Asp His Asn Trp Arg Tyr Cys Pro Ala His
                85                  90                  95      
His Ser Pro Leu Ser Ala Phe Cys Cys Pro Asp Gln Gln Cys Ile Cys
            100                 105                 110         
Gln Asp Cys Cys Gln Glu His Ser Gly His Thr Ile Val Ser Leu Asp
        115                 120                 125             
Ala Ala Arg Arg Asp Lys Glu Ala Glu Leu Gln Cys Thr Gln Leu Asp
    130                 135                 140                 
Leu Glu Arg Lys Leu Lys Leu Asn Glu Asn Ala Ile Ser Arg Leu Gln
145                 150                 155                 160 
Ala Asn Gln Lys Ser Val Leu Val Ser Val Ser Glu Val Lys Ala Val
                165                 170                 175     
Ala Glu Met Gln Phe Gly Glu Leu Leu Ala Ala Val Arg Lys Ala Gln
            180                 185                 190         
Ala Asn Val Met Leu Phe Leu Glu Glu Lys Glu Gln Ala Ala Leu Ser
        195                 200                 205             
Gln Ala Asn Gly Ile Lys Ala His Leu Glu Tyr Arg Ser Ala Glu Met
    210                 215                 220                 
Glu Lys Ser Lys Gln Glu Leu Glu Arg Met Ala Ala Ile Ser Asn Thr
225                 230                 235                 240 
Val Gln Phe Leu Glu Glu Tyr Cys Lys Phe Lys Asn Thr Glu Asp Ile
                245                 250                 255     
Thr Phe Pro Ser Val Tyr Val Gly Leu Lys Asp Lys Leu Ser Gly Ile
            260                 265                 270         
Arg Lys Val Ile Thr Glu Ser Thr Val His Leu Ile Gln Leu Leu Glu
        275                 280                 285             
Asn Tyr Lys Lys Lys Leu Gln Glu Phe Ser Lys Glu Glu Glu Tyr Asp
    290                 295                 300                 
Ile Arg Thr Gln Val Ser Ala Val Val Gln Arg Lys Tyr Trp Thr Ser
305                 310                 315                 320 
Lys Pro Glu Pro Ser Thr Arg Glu Gln Phe Leu Gln Tyr Ala Tyr Asp
                325                 330                 335     
Ile Thr Phe Asp Pro Asp Thr Ala His Lys Tyr Leu Arg Leu Gln Glu
            340                 345                 350         
Glu Asn Arg Lys Val Thr Asn Thr Thr Pro Trp Glu His Pro Tyr Pro
        355                 360                 365             
Asp Leu Pro Ser Arg Phe Leu His Trp Arg Gln Val Leu Ser Gln Gln
    370                 375                 380                 
Ser Leu Tyr Leu His Arg Tyr Tyr Phe Glu Val Glu Ile Phe Gly Ala
385                 390                 395                 400 
Gly Thr Tyr Val Gly Leu Thr Cys Lys Gly Ile Asp Arg Lys Gly Glu
                405                 410                 415     
Glu Arg Asn Ser Cys Ile Ser Gly Asn Asn Leu Ser Trp Ser Leu Gln
            420                 425                 430         
Trp Asn Gly Lys Glu Phe Thr Ala Trp Tyr Ser Asp Met Glu Thr Pro
        435                 440                 445             
Leu Lys Ala Gly Pro Phe Arg Arg Leu Gly Val Tyr Ile Asp Phe Pro
    450                 455                 460                 
Gly Gly Ile Leu Ser Phe Tyr Gly Val Glu Tyr Asp Thr Met Thr Leu
465                 470                 475                 480 
Val His Lys Phe Ala Cys Lys Phe Ser Glu Pro Val Tyr Ala Ala Phe
                485                 490                 495     
Trp Leu Ser Lys Lys Glu Asn Ala Ile Arg Ile Val Asp Leu Gly Glu
            500                 505                 510         
Glu Pro Glu Lys Pro Ala Pro Ser Leu Val Gly Thr Ala Pro
        515                 520                 525     


<210> 1735
<211> 229
<212> PRT
<213> Homo sapiens

<400> 1735
Met Ala Glu Glu Met Glu Ser Ser Leu Glu Ala Ser Phe Ser Ser Ser
 1               5                  10                  15      
Gly Ala Val Ser Gly Ala Ser Gly Phe Leu Pro Pro Ala Arg Ser Arg
            20                  25                  30          
Ile Phe Lys Ile Ile Val Ile Gly Asp Ser Asn Val Gly Lys Thr Cys
        35                  40                  45              
Leu Thr Tyr Arg Phe Cys Ala Gly Arg Phe Pro Asp Arg Thr Glu Ala
    50                  55                  60                  
Thr Ile Gly Val Asp Phe Arg Glu Arg Ala Val Glu Ile Asp Gly Glu
65                  70                  75                  80  
Arg Ile Lys Ile Gln Leu Trp Asp Thr Ala Gly Gln Glu Arg Phe Arg
                85                  90                  95      
Lys Ser Met Val Gln His Tyr Tyr Arg Asn Val His Ala Val Val Phe
            100                 105                 110         
Val Tyr Asp Met Thr Asn Met Ala Ser Phe His Ser Leu Pro Ser Trp
        115                 120                 125             
Ile Glu Glu Cys Lys Gln His Leu Leu Ala Asn Asp Ile Pro Arg Ile
    130                 135                 140                 
Leu Val Gly Asn Lys Cys Asp Leu Arg Ser Ala Ile Gln Val Pro Thr
145                 150                 155                 160 
Asp Leu Ala Gln Lys Phe Ala Asp Thr His Ser Met Pro Leu Phe Glu
                165                 170                 175     
Thr Ser Ala Lys Asn Pro Asn Asp Asn Asp His Val Glu Ala Ile Phe
            180                 185                 190         
Met Thr Leu Ala His Lys Leu Lys Ser His Lys Pro Leu Met Leu Ser
        195                 200                 205             
Gln Pro Pro Asp Asn Gly Ile Ile Leu Lys Pro Glu Pro Lys Pro Ala
    210                 215                 220                 
Met Thr Cys Trp Cys
225                 


<210> 1736
<211> 333
<212> PRT
<213> Homo sapiens

<400> 1736
Ala Thr Leu Lys Glu Lys Leu Ile Ala Pro Val Ala Glu Glu Glu Ala
 1               5                  10                  15      
Thr Val Pro Asn Asn Lys Ile Thr Val Val Gly Val Gly Gln Val Gly
            20                  25                  30          
Met Ala Cys Ala Ile Ser Ile Leu Gly Lys Ser Leu Ala Asp Glu Leu
        35                  40                  45              
Ala Leu Val Asp Val Leu Glu Asp Lys Leu Lys Gly Glu Met Met Asp
    50                  55                  60                  
Leu Gln His Gly Ser Leu Phe Leu Gln Thr Pro Lys Ile Val Ala Asp
65                  70                  75                  80  
Lys Asp Tyr Ser Val Thr Ala Asn Ser Lys Ile Val Val Val Thr Ala
                85                  90                  95      
Gly Val Arg Gln Gln Glu Gly Glu Ser Arg Leu Asn Leu Val Gln Arg
            100                 105                 110         
Asn Val Asn Val Phe Lys Phe Ile Ile Pro Gln Ile Val Lys Tyr Ser
        115                 120                 125             
Pro Asp Cys Ile Ile Ile Val Val Ser Asn Pro Val Asp Ile Leu Thr
    130                 135                 140                 
Tyr Val Thr Trp Lys Leu Ser Gly Leu Pro Lys His Arg Val Ile Gly
145                 150                 155                 160 
Ser Gly Cys Asn Leu Asp Ser Ala Arg Phe Arg Tyr Leu Met Ala Glu
                165                 170                 175     
Lys Leu Gly Ile His Pro Ser Ser Cys His Gly Trp Ile Leu Gly Glu
            180                 185                 190         
His Gly Asp Ser Ser Val Ala Val Trp Ser Gly Val Asn Val Ala Gly
        195                 200                 205             
Val Ser Leu Gln Glu Leu Asn Pro Glu Met Gly Thr Asp Asn Asp Ser
    210                 215                 220                 
Glu Asn Trp Lys Glu Val His Lys Met Val Val Glu Ser Ala Tyr Glu
225                 230                 235                 240 
Val Ile Lys Leu Lys Gly Tyr Thr Asn Trp Ala Ile Gly Leu Ser Val
                245                 250                 255     
Ala Asp Leu Ile Glu Ser Met Leu Lys Asn Leu Ser Arg Ile His Pro
            260                 265                 270         
Val Ser Thr Met Val Lys Gly Met Tyr Gly Ile Glu Asn Glu Val Phe
        275                 280                 285             
Leu Ser Leu Pro Cys Ile Leu Asn Ala Arg Gly Leu Thr Ser Val Ile
    290                 295                 300                 
Asn Gln Lys Leu Lys Asp Asp Glu Val Ala Gln Leu Lys Lys Ser Ala
305                 310                 315                 320 
Asp Thr Leu Trp Asp Ile Gln Lys Asp Leu Lys Asp Leu
                325                 330             


<210> 1737
<211> 906
<212> PRT
<213> Homo sapiens

<400> 1737
Met Ala Asn Glu Thr Gln Lys Val Gly Ala Ile His Phe Pro Phe Pro
 1               5                  10                  15      
Phe Thr Pro Tyr Ser Ile Gln Glu Asp Phe Met Ala Glu Leu Tyr Arg
            20                  25                  30          
Val Leu Glu Ala Gly Lys Ile Gly Ile Phe Glu Ser Pro Thr Gly Thr
        35                  40                  45              
Gly Lys Ser Leu Ser Leu Ile Cys Gly Ala Leu Ser Trp Leu Arg Asp
    50                  55                  60                  
Phe Glu Gln Lys Lys Arg Glu Glu Glu Ala Arg Leu Leu Glu Thr Gly
65                  70                  75                  80  
Thr Gly Pro Leu His Asp Glu Lys Asp Glu Ser Leu Cys Leu Ser Ser
                85                  90                  95      
Ser Cys Glu Gly Ala Ala Gly Thr Pro Arg Pro Ala Gly Glu Pro Ala
            100                 105                 110         
Trp Val Thr Gln Phe Val Gln Lys Lys Glu Glu Arg Asp Leu Val Asp
        115                 120                 125             
Arg Leu Lys Ala Glu Gln Ala Arg Arg Lys Gln Arg Glu Glu Arg Leu
    130                 135                 140                 
Gln Gln Leu Gln His Arg Val Gln Leu Lys Tyr Ala Ala Lys Arg Leu
145                 150                 155                 160 
Arg Gln Glu Glu Glu Glu Arg Glu Asn Leu Leu Arg Leu Ser Arg Glu
                165                 170                 175     
Met Leu Glu Thr Gly Pro Glu Ala Glu Arg Leu Glu Gln Leu Glu Ser
            180                 185                 190         
Gly Glu Glu Glu Leu Val Leu Ala Glu Tyr Glu Ser Asp Glu Glu Lys
        195                 200                 205             
Lys Val Ala Ser Arg Val Asp Glu Asp Glu Asp Asp Leu Glu Glu Glu
    210                 215                 220                 
His Ile Thr Lys Ile Tyr Tyr Cys Ser Arg Thr His Ser Gln Leu Ala
225                 230                 235                 240 
Gln Phe Val His Glu Val Lys Lys Ser Pro Phe Gly Lys Asp Val Arg
                245                 250                 255     
Leu Val Ser Leu Gly Ser Arg Gln Asn Leu Cys Val Asn Glu Asp Val
            260                 265                 270         
Lys Ser Leu Gly Ser Val Gln Leu Ile Asn Asp Arg Cys Val Asp Met
        275                 280                 285             
Gln Arg Ser Arg His Glu Lys Lys Lys Gly Ala Glu Glu Glu Lys Pro
    290                 295                 300                 
Lys Arg Arg Arg Gln Glu Lys Gln Ala Ala Cys Pro Phe Tyr Asn His
305                 310                 315                 320 
Glu Gln Met Gly Leu Leu Arg Asp Glu Ala Leu Ala Glu Val Lys Asp
                325                 330                 335     
Met Glu Gln Leu Leu Ala Leu Gly Lys Glu Ala Arg Ala Cys Pro Tyr
            340                 345                 350         
Tyr Gly Ser Arg Leu Ala Ile Pro Ala Ala Gln Leu Val Val Leu Pro
        355                 360                 365             
Tyr Gln Met Leu Leu His Ala Ala Thr Arg Gln Ala Ala Gly Ile Arg
    370                 375                 380                 
Leu Gln Asp Gln Val Val Ile Ile Asp Glu Ala His Asn Leu Ile Asp
385                 390                 395                 400 
Thr Ile Thr Gly Met His Ser Val Glu Val Ser Gly Ser Gln Leu Cys
                405                 410                 415     
Gln Ala His Ser Gln Leu Leu Gln Tyr Val Glu Arg Tyr Gly Lys Arg
            420                 425                 430         
Leu Lys Ala Lys Asn Leu Met Tyr Leu Lys Gln Ile Leu Tyr Leu Leu
        435                 440                 445             
Glu Lys Phe Val Ala Val Leu Gly Gly Asn Ile Lys Gln Asn Pro Asn
    450                 455                 460                 
Thr Gln Ser Leu Ser Gln Thr Gly Thr Glu Leu Lys Thr Ile Asn Asp
465                 470                 475                 480 
Phe Leu Phe Gln Ser Gln Ile Asp Asn Ile Asn Leu Phe Lys Val Gln
                485                 490                 495     
Arg Tyr Cys Glu Lys Ser Met Ile Ser Arg Lys Leu Phe Gly Phe Thr
            500                 505                 510         
Glu Arg Tyr Gly Ala Val Phe Ser Ser Arg Glu Gln Pro Lys Leu Ala
        515                 520                 525             
Gly Phe Gln Gln Phe Leu Gln Ser Leu Gln Pro Arg Thr Thr Glu Ala
    530                 535                 540                 
Leu Ala Ala Pro Ala Asp Glu Ser Gln Ala Ser Thr Leu Arg Pro Ala
545                 550                 555                 560 
Ser Pro Leu Met His Ile Glu Gly Phe Leu Ala Ala Leu Thr Thr Ala
                565                 570                 575     
Asn Gln Asp Gly Arg Val Ile Leu Ser Arg Gln Gly Ser Leu Ser Gln
            580                 585                 590         
Ser Thr Leu Lys Phe Leu Leu Leu Asn Pro Ala Val His Phe Ala Gln
        595                 600                 605             
Val Val Lys Glu Cys Arg Ala Val Val Ile Ala Gly Gly Thr Met Gln
    610                 615                 620                 
Pro Val Ser Asp Phe Arg Gln Gln Leu Leu Ala Cys Ala Gly Val Glu
625                 630                 635                 640 
Ala Glu Arg Val Val Glu Phe Ser Cys Gly His Val Ile Pro Pro Asp
                645                 650                 655     
Asn Ile Leu Pro Leu Val Ile Cys Ser Gly Ile Ser Asn Gln Pro Leu
            660                 665                 670         
Glu Phe Thr Phe Gln Lys Arg Glu Leu Pro Gln Met Met Asp Glu Val
        675                 680                 685             
Gly Arg Ile Leu Cys Asn Leu Cys Gly Val Val Pro Gly Gly Val Val
    690                 695                 700                 
Cys Phe Phe Pro Ser Tyr Glu Tyr Leu Arg Gln Val His Ala His Trp
705                 710                 715                 720 
Glu Lys Gly Gly Leu Leu Gly Arg Leu Ala Ala Arg Lys Lys Ile Phe
                725                 730                 735     
Gln Glu Pro Lys Ser Ala His Gln Val Glu Gln Val Leu Leu Ala Tyr
            740                 745                 750         
Ser Arg Cys Ile Gln Ala Cys Gly Gln Glu Arg Gly Gln Val Thr Gly
        755                 760                 765             
Ala Leu Leu Leu Ser Val Val Gly Gly Lys Met Ser Glu Gly Ile Asn
    770                 775                 780                 
Phe Ser Asp Asn Leu Gly Arg Cys Val Val Met Val Gly Met Pro Phe
785                 790                 795                 800 
Pro Asn Ile Arg Ser Ala Glu Leu Gln Glu Lys Met Ala Tyr Leu Asp
                805                 810                 815     
Gln Thr Leu Pro Arg Ala Pro Gly Gln Ala Pro Pro Gly Lys Ala Leu
            820                 825                 830         
Val Glu Asn Leu Cys Met Lys Ala Val Asn Gln Ser Ile Gly Arg Ala
        835                 840                 845             
Ile Arg His Gln Lys Asp Phe Ala Ser Ile Val Leu Leu Asp Gln Arg
    850                 855                 860                 
Tyr Ala Arg Pro Pro Val Leu Ala Lys Leu Pro Ala Trp Ile Arg Ala
865                 870                 875                 880 
Arg Val Glu Val Lys Ala Thr Phe Gly Pro Ala Ile Ala Ala Val Gln
                885                 890                 895     
Lys Phe His Arg Glu Lys Ser Ala Ser Ser
            900                 905     


<210> 1738
<211> 299
<212> PRT
<213> Homo sapiens

<400> 1738
Met Arg Pro Leu Gln Ile Val Pro Ser Arg Leu Ile Ser Gln Leu Tyr
 1               5                  10                  15      
Cys Gly Leu Lys Pro Pro Ala Ser Thr Arg Asn Gln Ile Cys Leu Lys
            20                  25                  30          
Met Ala Arg Pro Ser Ser Ser Met Ala Asp Phe Arg Lys Phe Phe Ala
        35                  40                  45              
Lys Ala Lys His Ile Val Ile Ile Ser Gly Ala Gly Val Ser Ala Glu
    50                  55                  60                  
Ser Gly Val Pro Thr Phe Arg Gly Ala Gly Gly Tyr Trp Arg Lys Trp
65                  70                  75                  80  
Gln Ala Gln Asp Leu Ala Thr Pro Leu Ala Phe Ala His Asn Pro Ser
                85                  90                  95      
Arg Val Trp Glu Phe Tyr His Tyr Arg Arg Glu Val Met Gly Ser Lys
            100                 105                 110         
Glu Pro Asn Ala Gly His Arg Ala Ile Ala Glu Cys Glu Thr Arg Leu
        115                 120                 125             
Gly Lys Gln Gly Arg Arg Val Val Val Ile Thr Gln Asn Ile Asp Glu
    130                 135                 140                 
Leu His Arg Lys Ala Gly Thr Lys Asn Leu Leu Glu Ile His Gly Ser
145                 150                 155                 160 
Leu Phe Lys Thr Arg Cys Thr Ser Cys Gly Val Val Ala Glu Asn Tyr
                165                 170                 175     
Lys Ser Pro Ile Cys Pro Ala Leu Ser Gly Lys Gly Ala Pro Glu Pro
            180                 185                 190         
Gly Thr Gln Asp Ala Ser Ile Pro Val Glu Lys Leu Pro Arg Cys Glu
        195                 200                 205             
Glu Ala Gly Cys Gly Gly Leu Leu Arg Pro His Val Val Trp Phe Gly
    210                 215                 220                 
Glu Asn Leu Asp Pro Ala Ile Leu Glu Glu Val Asp Arg Glu Leu Ala
225                 230                 235                 240 
His Cys Asp Leu Cys Leu Val Val Gly Thr Ser Ser Val Val Tyr Pro
                245                 250                 255     
Ala Ala Met Phe Ala Pro Gln Val Ala Ala Arg Gly Val Pro Val Ala
            260                 265                 270         
Glu Phe Asn Thr Glu Thr Thr Pro Ala Thr Asn Arg Phe Ser His Leu
        275                 280                 285             
Ile Ser Ile Ser Ser Leu Ile Ile Ile Lys Asn
    290                 295                 


<210> 1739
<211> 4349
<212> PRT
<213> Homo sapiens

<400> 1739
Met Thr Ile Ala Leu Leu Gly Phe Ala Ile Phe Leu Leu His Cys Ala
 1               5                  10                  15      
Thr Cys Glu Lys Pro Leu Glu Gly Ile Leu Ser Ser Ser Ala Trp His
            20                  25                  30          
Phe Thr His Ser His Tyr Asn Ala Thr Ile Tyr Glu Asn Ser Ser Pro
        35                  40                  45              
Lys Thr Tyr Val Glu Ser Phe Glu Lys Met Gly Ile Tyr Leu Ala Glu
    50                  55                  60                  
Pro Gln Trp Ala Val Arg Tyr Arg Ile Ile Ser Gly Asp Val Ala Asn
65                  70                  75                  80  
Val Phe Lys Thr Glu Glu Tyr Val Val Gly Asn Phe Cys Phe Leu Arg
                85                  90                  95      
Ile Arg Thr Lys Ser Ser Asn Thr Ala Leu Leu Asn Arg Glu Val Arg
            100                 105                 110         
Asp Ser Tyr Thr Leu Ile Ile Gln Ala Thr Glu Lys Thr Leu Glu Leu
        115                 120                 125             
Glu Ala Leu Thr Arg Val Val Val His Ile Leu Asp Gln Asn Asp Leu
    130                 135                 140                 
Lys Pro Leu Phe Ser Pro Pro Ser Tyr Arg Val Thr Ile Ser Glu Asp
145                 150                 155                 160 
Met Pro Leu Lys Ser Pro Ile Cys Lys Val Thr Ala Thr Asp Ala Asp
                165                 170                 175     
Leu Gly Gln Asn Ala Glu Phe Tyr Tyr Ala Phe Asn Thr Arg Ser Glu
            180                 185                 190         
Met Phe Ala Ile His Pro Thr Ser Gly Val Val Thr Val Ala Gly Lys
        195                 200                 205             
Leu Asn Val Thr Trp Arg Gly Lys His Glu Leu Gln Val Leu Ala Val
    210                 215                 220                 
Asp Arg Met Arg Lys Ile Ser Glu Gly Asn Gly Phe Gly Ser Leu Ala
225                 230                 235                 240 
Ala Leu Val Val His Val Glu Pro Ala Leu Arg Lys Pro Pro Ala Ile
                245                 250                 255     
Ala Ser Val Val Val Thr Pro Pro Asp Ser Asn Asp Gly Thr Thr Tyr
            260                 265                 270         
Ala Thr Val Leu Val Asp Ala Asn Ser Ser Gly Ala Glu Val Glu Ser
        275                 280                 285             
Val Glu Val Val Gly Gly Asp Pro Gly Lys His Phe Lys Ala Ile Lys
    290                 295                 300                 
Ser Tyr Ala Arg Ser Asn Glu Phe Ser Leu Val Ser Val Lys Asp Ile
305                 310                 315                 320 
Asn Trp Met Glu Tyr Leu His Gly Phe Asn Leu Ser Leu Gln Ala Arg
                325                 330                 335     
Ser Gly Ser Gly Pro Tyr Phe Tyr Ser Gln Ile Arg Gly Phe His Leu
            340                 345                 350         
Pro Pro Ser Lys Leu Ser Ser Leu Lys Phe Glu Lys Ala Val Tyr Arg
        355                 360                 365             
Val Gln Leu Ser Glu Phe Ser Pro Pro Gly Ser Arg Val Val Met Val
    370                 375                 380                 
Arg Val Thr Pro Ala Phe Pro Asn Leu Gln Tyr Val Leu Lys Pro Ser
385                 390                 395                 400 
Ser Glu Asn Val Gly Phe Lys Leu Asn Ala Arg Thr Gly Leu Ile Thr
                405                 410                 415     
Thr Thr Lys Leu Met Asp Phe His Asp Arg Ala His Tyr Gln Leu His
            420                 425                 430         
Ile Arg Thr Ser Pro Gly Gln Ala Ser Thr Val Val Val Ile Asp Ile
        435                 440                 445             
Val Asp Cys Asn Asn His Ala Pro Leu Phe Asn Arg Ser Ser Tyr Asp
    450                 455                 460                 
Gly Thr Leu Asp Glu Asn Ile Pro Pro Gly Thr Ser Val Leu Ala Val
465                 470                 475                 480 
Thr Ala Thr Asp Arg Asp His Gly Glu Asn Gly Tyr Val Thr Tyr Ser
                485                 490                 495     
Ile Ala Gly Pro Lys Ala Leu Pro Phe Ser Ile Asp Pro Tyr Leu Gly
            500                 505                 510         
Ile Ile Ser Thr Ser Lys Pro Met Asp Tyr Glu Leu Met Lys Arg Ile
        515                 520                 525             
Tyr Thr Phe Arg Val Arg Ala Ser Asp Trp Gly Ser Pro Phe Arg Arg
    530                 535                 540                 
Glu Lys Glu Val Ser Ile Phe Leu Gln Leu Arg Asn Leu Asn Asp Asn
545                 550                 555                 560 
Gln Pro Met Phe Glu Glu Val Asn Cys Thr Gly Ser Ile Arg Gln Asp
                565                 570                 575     
Trp Pro Val Gly Lys Ser Ile Met Thr Met Ser Ala Ile Asp Val Asp
            580                 585                 590         
Glu Leu Gln Asn Leu Lys Tyr Glu Ile Val Ser Gly Asn Glu Leu Glu
        595                 600                 605             
Tyr Phe Asp Leu Asn His Phe Ser Gly Val Ile Ser Leu Lys Arg Pro
    610                 615                 620                 
Phe Ile Asn Leu Thr Ala Gly Gln Pro Thr Ser Tyr Ser Leu Lys Ile
625                 630                 635                 640 
Thr Ala Ser Asp Gly Lys Asn Tyr Ala Ser Pro Thr Thr Leu Asn Ile
                645                 650                 655     
Thr Val Val Lys Asp Pro His Phe Glu Val Pro Val Thr Cys Asp Lys
            660                 665                 670         
Thr Gly Val Leu Thr Gln Phe Thr Lys Thr Ile Leu His Phe Ile Gly
        675                 680                 685             
Leu Gln Asn Gln Glu Ser Ser Asp Glu Glu Phe Thr Ser Leu Ser Thr
    690                 695                 700                 
Tyr Gln Ile Asn His Tyr Thr Pro Gln Phe Glu Asp His Phe Pro Gln
705                 710                 715                 720 
Ser Ile Asp Val Leu Glu Ser Val Pro Ile Asn Thr Pro Leu Ala Arg
                725                 730                 735     
Leu Ala Ala Thr Asp Pro Asp Ala Gly Phe Asn Gly Lys Leu Val Tyr
            740                 745                 750         
Val Ile Ala Asp Gly Asn Glu Glu Gly Cys Phe Asp Ile Glu Leu Glu
        755                 760                 765             
Thr Gly Leu Leu Thr Val Ala Ala Pro Leu Asp Tyr Glu Ala Thr Asn
    770                 775                 780                 
Phe Tyr Ile Leu Asn Val Thr Val Tyr Asp Leu Gly Thr Pro Gln Lys
785                 790                 795                 800 
Ser Ser Trp Lys Leu Leu Thr Val Asn Val Lys Asp Trp Asn Asp Asn
                805                 810                 815     
Ala Pro Arg Phe Pro Pro Gly Gly Tyr Gln Leu Thr Ile Ser Glu Asp
            820                 825                 830         
Thr Glu Val Gly Thr Thr Ile Ala Glu Leu Thr Thr Lys Asp Ala Asp
        835                 840                 845             
Ser Glu Asp Asn Gly Arg Val Arg Tyr Thr Leu Leu Ser Pro Thr Glu
    850                 855                 860                 
Lys Phe Ser Leu His Pro Leu Thr Gly Glu Leu Val Val Thr Gly His
865                 870                 875                 880 
Leu Asp Arg Glu Ser Glu Pro Arg Tyr Ile Leu Lys Val Glu Ala Arg
                885                 890                 895     
Asp Gln Pro Ser Lys Gly His Gln Leu Phe Ser Val Thr Asp Leu Ile
            900                 905                 910         
Ile Thr Leu Glu Asp Val Asn Asp Asn Ser Pro Gln Cys Ile Thr Glu
        915                 920                 925             
His Asn Arg Leu Lys Val Pro Glu Asp Leu Pro Pro Gly Thr Val Leu
    930                 935                 940                 
Thr Phe Leu Asp Ala Ser Asp Pro Asp Leu Gly Pro Ala Gly Glu Val
945                 950                 955                 960 
Arg Tyr Val Leu Met Asp Gly Ala His Gly Thr Phe Arg Val Asp Leu
                965                 970                 975     
Met Thr Gly Ala Leu Ile Leu Glu Arg Glu Leu Asp Phe Glu Arg Arg
            980                 985                 990         
Ala Gly Tyr Asn Leu Ser Leu Trp Ala Ser Asp Gly Gly Arg Pro Leu
        995                 1000                1005            
Ala Arg Arg Thr Leu Cys His Val Glu Val Ile Val Leu Asp Val Asn
    1010                1015                1020                
Glu Asn Leu His Pro Pro His Phe Ala Ser Phe Val His Gln Gly Gln
1025                1030                1035                1040
Val Gln Glu Asn Ser Pro Ser Gly Thr Gln Val Ile Val Val Ala Ala
                1045                1050                1055    
Gln Asp Asp Asp Ser Gly Leu Asp Gly Glu Leu Gln Tyr Phe Leu Arg
            1060                1065                1070        
Ala Gly Thr Gly Leu Ala Ala Phe Ser Ile Asn Gln Asp Thr Gly Met
        1075                1080                1085            
Ile Gln Thr Leu Ala Pro Leu Asp Arg Glu Phe Ala Ser Tyr Tyr Trp
    1090                1095                1100                
Leu Thr Val Leu Ala Val Asp Arg Gly Ser Val Pro Leu Ser Ser Val
1105                1110                1115                1120
Thr Glu Val Tyr Ile Glu Val Thr Asp Ala Asn Asp Asn Pro Pro Gln
                1125                1130                1135    
Met Ser Gln Ala Val Phe Tyr Pro Ser Ile Gln Glu Asp Ala Pro Val
            1140                1145                1150        
Gly Thr Ser Val Leu Gln Leu Asp Ala Trp Asp Pro Asp Ser Ser Ser
        1155                1160                1165            
Lys Gly Lys Leu Thr Phe Asn Ile Thr Ser Gly Asn Tyr Met Gly Phe
    1170                1175                1180                
Phe Met Ile His Pro Val Thr Gly Leu Leu Ser Thr Ala Gln Gln Leu
1185                1190                1195                1200
Asp Arg Glu Asn Lys Asp Glu His Ile Leu Glu Val Thr Val Leu Asp
                1205                1210                1215    
Asn Gly Glu Pro Ser Leu Lys Ser Thr Ser Arg Val Val Val Gly Ile
            1220                1225                1230        
Leu Asp Val Asn Asp Asn Pro Pro Ile Phe Ser His Lys Leu Phe Asn
        1235                1240                1245            
Val Arg Leu Pro Glu Arg Leu Ser Pro Val Ser Pro Gly Pro Val Tyr
    1250                1255                1260                
Arg Leu Val Ala Ser Asp Leu Asp Glu Gly Leu Asn Gly Arg Val Thr
1265                1270                1275                1280
Tyr Ser Ile Glu Asp Ser Asp Glu Glu Ala Phe Ser Ile Asp Leu Val
                1285                1290                1295    
Thr Gly Val Val Ser Ser Ser Ser Thr Phe Thr Ala Gly Glu Tyr Asn
            1300                1305                1310        
Ile Leu Thr Ile Lys Ala Thr Asp Ser Gly Gln Pro Pro Leu Ser Ala
        1315                1320                1325            
Ser Val Arg Leu His Ile Glu Trp Ile Pro Trp Pro Arg Pro Ser Ser
    1330                1335                1340                
Ile Pro Leu Ala Phe Asp Glu Thr Tyr Tyr Ser Phe Thr Val Met Glu
1345                1350                1355                1360
Thr Asp Pro Val Asn His Met Val Gly Val Ile Ser Val Glu Gly Arg
                1365                1370                1375    
Pro Gly Leu Phe Trp Phe Asn Ile Ser Gly Gly Asp Lys Asp Met Asp
            1380                1385                1390        
Phe Asp Ile Glu Lys Thr Thr Gly Ser Ile Val Ile Ala Arg Pro Leu
        1395                1400                1405            
Asp Thr Arg Arg Arg Ser Asn Tyr Asn Leu Thr Val Glu Val Thr Asp
    1410                1415                1420                
Gly Ser Arg Thr Ile Ala Thr Gln Val His Ile Phe Met Ile Ala Asn
1425                1430                1435                1440
Ile Asn His His Arg Pro Gln Phe Leu Glu Thr Arg Tyr Glu Val Arg
                1445                1450                1455    
Val Pro Gln Asp Thr Val Pro Gly Val Glu Leu Leu Arg Val Gln Ala
            1460                1465                1470        
Ile Asp Gln Asp Lys Gly Lys Ser Leu Ile Tyr Thr Ile His Gly Ser
        1475                1480                1485            
Gln Asp Pro Gly Ser Ala Ser Leu Phe Gln Leu Asp Pro Ser Ser Gly
    1490                1495                1500                
Val Leu Val Thr Val Gly Lys Leu Asp Leu Gly Ser Gly Pro Ser Gln
1505                1510                1515                1520
His Thr Leu Thr Val Met Val Arg Asp Gln Glu Ile Pro Ile Lys Arg
                1525                1530                1535    
Asn Phe Val Trp Val Thr Ile His Val Glu Asp Gly Asn Leu His Pro
            1540                1545                1550        
Pro Arg Phe Thr Gln Leu His Tyr Glu Ala Ser Val Pro Asp Thr Ile
        1555                1560                1565            
Ala Pro Gly Thr Glu Leu Leu Gln Val Arg Ala Met Asp Ala Asp Arg
    1570                1575                1580                
Gly Val Asn Ala Glu Val His Tyr Ser Leu Leu Lys Gly Asn Ser Glu
1585                1590                1595                1600
Gly Phe Phe Asn Ile Asn Ala Leu Leu Gly Ile Ile Thr Leu Ala Gln
                1605                1610                1615    
Lys Leu Asp Gln Ala Asn His Ala Pro His Thr Leu Thr Val Lys Ala
            1620                1625                1630        
Glu Asp Gln Gly Ser Pro Gln Trp His Asp Leu Ala Thr Val Ile Ile
        1635                1640                1645            
His Val Tyr Pro Ser Asp Arg Ser Ala Pro Ile Phe Ser Lys Ser Glu
    1650                1655                1660                
Tyr Phe Val Glu Ile Pro Glu Ser Ile Pro Val Gly Ser Pro Ile Leu
1665                1670                1675                1680
Leu Val Ser Ala Met Ser Pro Ser Glu Val Thr Tyr Glu Leu Arg Glu
                1685                1690                1695    
Gly Asn Lys Asp Gly Val Phe Ser Met Asn Ser Tyr Ser Gly Leu Ile
            1700                1705                1710        
Ser Thr Gln Lys Lys Leu Asp His Glu Lys Ile Ser Ser Tyr Gln Leu
        1715                1720                1725            
Lys Ile Arg Gly Ser Asn Met Ala Gly Ala Phe Thr Asp Val Met Val
    1730                1735                1740                
Val Val Asp Ile Ile Asp Glu Asn Asp Asn Ala Pro Met Phe Leu Lys
1745                1750                1755                1760
Ser Thr Phe Val Gly Gln Ile Ser Glu Ala Ala Pro Leu Tyr Ser Met
                1765                1770                1775    
Ile Met Asp Lys Asn Asn Asn Pro Phe Val Ile His Ala Ser Asp Ser
            1780                1785                1790        
Asp Lys Glu Ala Asn Ser Leu Leu Val Tyr Lys Ile Leu Glu Pro Glu
        1795                1800                1805            
Ala Leu Lys Phe Phe Lys Ile Asp Pro Ser Met Gly Thr Leu Thr Ile
    1810                1815                1820                
Val Ser Glu Met Asp Tyr Glu Ser Met Pro Ser Phe Gln Phe Cys Val
1825                1830                1835                1840
Tyr Val His Asp Gln Gly Ser Pro Val Leu Phe Ala Pro Arg Pro Ala
                1845                1850                1855    
Gln Val Ile Ile His Val Arg Asp Val Asn Asp Ser Pro Pro Arg Phe
            1860                1865                1870        
Ser Glu Gln Ile Tyr Glu Val Ala Ile Val Gly Pro Ile His Pro Gly
        1875                1880                1885            
Met Glu Leu Leu Met Val Arg Ala Ser Asp Glu Asp Ser Glu Val Asn
    1890                1895                1900                
Tyr Ser Ile Lys Thr Gly Asn Ala Asp Glu Ala Val Thr Ile His Pro
1905                1910                1915                1920
Val Thr Gly Ser Ile Ser Val Leu Asn Pro Ala Phe Leu Gly Leu Ser
                1925                1930                1935    
Arg Lys Leu Thr Ile Arg Ala Ser Asp Gly Leu Tyr Gln Asp Thr Ala
            1940                1945                1950        
Leu Val Lys Ile Ser Leu Thr Gln Val Leu Asp Lys Ser Leu Gln Phe
        1955                1960                1965            
Asp Gln Asp Val Tyr Trp Ala Ala Val Lys Glu Asn Leu Gln Asp Arg
    1970                1975                1980                
Lys Ala Leu Val Ile Leu Gly Ala Gln Gly Asn His Leu Asn Asp Thr
1985                1990                1995                2000
Leu Ser Tyr Phe Leu Leu Asn Gly Thr Asp Met Phe His Met Val Gln
                2005                2010                2015    
Ser Ala Gly Val Leu Gln Thr Arg Gly Val Ala Phe Asp Arg Glu Gln
            2020                2025                2030        
Gln Asp Thr His Glu Leu Ala Val Glu Val Arg Asp Asn Arg Thr Pro
        2035                2040                2045            
Gln Arg Val Ala Gln Gly Leu Val Arg Val Ser Ile Glu Asp Val Asn
    2050                2055                2060                
Asp Asn Pro Pro Lys Phe Lys His Leu Pro Tyr Tyr Thr Ile Ile Gln
2065                2070                2075                2080
Asp Gly Thr Glu Pro Gly Asp Val Leu Phe Gln Val Ser Ala Thr Asp
                2085                2090                2095    
Glu Asp Leu Gly Thr Asn Gly Ala Val Thr Tyr Glu Phe Ala Glu Asp
            2100                2105                2110        
Tyr Thr Tyr Phe Arg Ile Asp Pro Tyr Leu Gly Asp Ile Ser Leu Lys
        2115                2120                2125            
Lys Pro Phe Asp Tyr Gln Ala Leu Asn Lys Tyr His Leu Lys Val Ile
    2130                2135                2140                
Ala Arg Asp Gly Gly Thr Pro Ser Leu Gln Ser Glu Glu Glu Val Leu
2145                2150                2155                2160
Val Thr Val Arg Asn Lys Ser Asn Pro Leu Phe Gln Ser Pro Tyr Tyr
                2165                2170                2175    
Lys Val Arg Val Pro Glu Asn Ile Thr Leu Tyr Thr Pro Ile Leu His
            2180                2185                2190        
Thr Gln Ala Arg Ser Pro Glu Gly Leu Arg Leu Ile Tyr Asn Ile Val
        2195                2200                2205            
Glu Glu Glu Pro Leu Met Leu Phe Thr Thr Asp Phe Lys Thr Gly Val
    2210                2215                2220                
Leu Thr Val Thr Gly Pro Leu Asp Tyr Glu Ser Lys Thr Lys His Val
2225                2230                2235                2240
Phe Thr Val Arg Ala Thr Asp Thr Ala Leu Gly Ser Phe Ser Glu Ala
                2245                2250                2255    
Thr Val Glu Val Leu Val Glu Asp Val Asn Asp Asn Pro Pro Thr Phe
            2260                2265                2270        
Ser Gln Leu Val Tyr Thr Thr Ser Ile Ser Glu Gly Leu Pro Ala Gln
        2275                2280                2285            
Thr Pro Val Ile Gln Leu Leu Ala Ser Asp Gln Asp Ser Gly Arg Asn
    2290                2295                2300                
Arg Asp Val Ser Tyr Gln Ile Val Glu Asp Gly Ser Asp Val Ser Lys
2305                2310                2315                2320
Phe Phe Gln Ile Asn Gly Ser Thr Gly Glu Met Ser Thr Val Gln Glu
                2325                2330                2335    
Leu Asp Tyr Glu Ala Gln Gln His Phe His Val Lys Val Arg Ala Met
            2340                2345                2350        
Asp Lys Gly Asp Pro Pro Leu Thr Gly Glu Thr Leu Val Val Val Asn
        2355                2360                2365            
Val Ser Asp Ile Asn Asp Asn Pro Pro Glu Phe Arg Gln Pro Gln Tyr
    2370                2375                2380                
Glu Ala Asn Val Ser Glu Leu Ala Thr Cys Gly His Leu Val Leu Lys
2385                2390                2395                2400
Val Gln Ala Ile Asp Pro Asp Ser Arg Asp Thr Ser Arg Leu Glu Tyr
                2405                2410                2415    
Leu Ile Leu Ser Gly Asn Gln Asp Arg His Phe Phe Ile Asn Ser Ser
            2420                2425                2430        
Ser Gly Ile Ile Ser Met Phe Asn Leu Cys Lys Lys His Leu Asp Ser
        2435                2440                2445            
Ser Tyr Asn Leu Arg Val Gly Ala Ser Asp Gly Val Phe Arg Ala Thr
    2450                2455                2460                
Val Pro Val Tyr Ile Asn Thr Thr Asn Ala Asn Lys Tyr Ser Pro Glu
2465                2470                2475                2480
Phe Gln Gln His Leu Tyr Glu Ala Glu Leu Ala Glu Asn Ala Met Val
                2485                2490                2495    
Gly Thr Lys Val Ile Asp Leu Leu Ala Ile Asp Lys Asp Ser Gly Pro
            2500                2505                2510        
Tyr Gly Thr Ile Asp Tyr Thr Ile Ile Asn Lys Leu Ala Ser Glu Lys
        2515                2520                2525            
Phe Ser Ile Asn Pro Asn Gly Gln Ile Ala Thr Leu Gln Lys Leu Asp
    2530                2535                2540                
Arg Glu Asn Ser Thr Glu Arg Val Ile Ala Ile Lys Val Met Ala Arg
2545                2550                2555                2560
Asp Gly Gly Gly Arg Val Ala Phe Cys Thr Val Lys Ile Ile Leu Thr
                2565                2570                2575    
Asp Glu Asn Asp Asn Pro Pro Gln Phe Lys Ala Ser Glu Tyr Thr Val
            2580                2585                2590        
Ser Ile Gln Ser Asn Val Ser Lys Asp Ser Pro Val Ile Gln Val Leu
        2595                2600                2605            
Ala Tyr Asp Ala Asp Glu Gly Gln Asn Ala Asp Val Thr Tyr Ser Val
    2610                2615                2620                
Asn Pro Glu Asp Leu Val Lys Asp Val Ile Glu Ile Asn Pro Val Thr
2625                2630                2635                2640
Gly Val Val Lys Val Lys Asp Ser Leu Val Gly Leu Glu Asn Gln Thr
                2645                2650                2655    
Leu Asp Phe Phe Ile Lys Ala Gln Asp Gly Gly Pro Pro His Trp Asn
            2660                2665                2670        
Ser Leu Val Pro Val Arg Leu Gln Val Val Pro Lys Lys Val Ser Leu
        2675                2680                2685            
Pro Lys Phe Ser Glu Pro Leu Tyr Thr Phe Ser Ala Pro Glu Asp Leu
    2690                2695                2700                
Pro Glu Gly Ser Glu Ile Gly Ile Val Lys Ala Val Ala Ala Gln Asp
2705                2710                2715                2720
Pro Val Ile Tyr Ser Leu Val Arg Gly Thr Thr Pro Glu Ser Asn Lys
                2725                2730                2735    
Asp Gly Val Phe Ser Leu Asp Pro Asp Thr Gly Val Ile Lys Val Arg
            2740                2745                2750        
Lys Pro Met Asp His Glu Ser Thr Lys Leu Tyr Gln Ile Asp Val Met
        2755                2760                2765            
Ala His Cys Leu Gln Asn Thr Asp Val Val Ser Leu Val Ser Val Asn
    2770                2775                2780                
Ile Gln Val Gly Asp Val Asn Asp Asn Arg Pro Val Phe Glu Ala Asp
2785                2790                2795                2800
Pro Tyr Lys Ala Val Leu Thr Glu Asn Met Pro Val Gly Thr Ser Val
                2805                2810                2815    
Ile Gln Val Thr Ala Ile Asp Lys Asp Thr Gly Arg Asp Gly Gln Val
            2820                2825                2830        
Ser Tyr Arg Leu Ser Ala Asp Pro Gly Ser Asn Val His Glu Leu Phe
        2835                2840                2845            
Ala Ile Asp Ser Glu Ser Gly Trp Ile Thr Thr Leu Gln Glu Leu Asp
    2850                2855                2860                
Cys Glu Thr Cys Gln Thr Tyr His Phe His Val Val Ala Tyr Asp His
2865                2870                2875                2880
Gly Gln Thr Ile Gln Leu Ser Ser Gln Ala Leu Val Gln Val Ser Ile
                2885                2890                2895    
Thr Asp Glu Asn Asp Asn Ala Pro Arg Phe Ala Ser Glu Glu Tyr Arg
            2900                2905                2910        
Gly Ser Val Val Glu Asn Ser Glu Pro Gly Glu Leu Val Ala Thr Leu
        2915                2920                2925            
Lys Thr Leu Asp Ala Asp Ile Ser Glu Gln Asn Arg Gln Val Thr Cys
    2930                2935                2940                
Tyr Ile Thr Glu Gly Asp Pro Leu Gly Gln Phe Gly Ile Ser Gln Val
2945                2950                2955                2960
Gly Asp Glu Trp Arg Ile Ser Ser Arg Lys Thr Leu Asp Arg Glu His
                2965                2970                2975    
Thr Ala Lys Tyr Leu Leu Arg Val Thr Ala Ser Asp Gly Lys Phe Gln
            2980                2985                2990        
Ala Ser Val Thr Val Glu Ile Phe Val Leu Asp Val Asn Asp Asn Ser
        2995                3000                3005            
Pro Gln Cys Ser Gln Leu Leu Tyr Thr Gly Lys Val His Glu Asp Val
    3010                3015                3020                
Phe Pro Gly His Phe Ile Leu Lys Val Ser Ala Thr Asp Leu Asp Thr
3025                3030                3035                3040
Asp Thr Asn Ala Gln Ile Thr Tyr Ser Leu His Gly Pro Gly Ala His
                3045                3050                3055    
Glu Phe Lys Leu Asp Pro His Thr Gly Glu Leu Thr Thr Leu Thr Ala
            3060                3065                3070        
Leu Asp Arg Glu Arg Lys Asp Val Phe Asn Leu Val Ala Lys Ala Thr
        3075                3080                3085            
Asp Gly Gly Gly Arg Ser Cys Gln Ala Asp Ile Thr Leu His Val Glu
    3090                3095                3100                
Asp Val Asn Asp Asn Ala Pro Arg Phe Phe Pro Ser His Cys Ala Val
3105                3110                3115                3120
Ala Val Phe Asp Asn Thr Thr Val Lys Thr Pro Val Ala Val Val Phe
                3125                3130                3135    
Ala Arg Asp Pro Asp Gln Gly Ala Asn Ala Gln Val Val Tyr Ser Leu
            3140                3145                3150        
Pro Asp Ser Ala Glu Gly His Phe Ser Ile Asp Ala Thr Thr Gly Val
        3155                3160                3165            
Ile Arg Leu Glu Lys Pro Leu Gln Val Arg Pro Gln Ala Pro Leu Glu
    3170                3175                3180                
Leu Thr Val Arg Ala Ser Asp Leu Gly Thr Pro Ile Pro Leu Ser Thr
3185                3190                3195                3200
Leu Gly Thr Val Thr Val Ser Val Val Gly Leu Glu Asp Tyr Leu Pro
                3205                3210                3215    
Val Phe Leu Asn Thr Glu His Ser Val Gln Val Pro Glu Asp Ala Pro
            3220                3225                3230        
Pro Gly Thr Glu Val Leu Gln Leu Ala Thr Leu Thr Arg Pro Gly Ala
        3235                3240                3245            
Glu Lys Thr Gly Tyr Arg Val Val Ser Gly Asn Glu Gln Gly Arg Phe
    3250                3255                3260                
Arg Leu Asp Ala Arg Thr Gly Ile Leu Tyr Val Asn Ala Ser Leu Asp
3265                3270                3275                3280
Phe Glu Thr Ser Pro Lys Tyr Phe Leu Ser Ile Glu Cys Ser Arg Lys
                3285                3290                3295    
Ser Ser Ser Ser Leu Ser Asp Val Thr Thr Val Met Val Asn Ile Thr
            3300                3305                3310        
Asp Val Asn Glu His Arg Pro Gln Phe Pro Gln Asp Pro Tyr Ser Thr
        3315                3320                3325            
Arg Val Leu Glu Asn Ala Leu Val Gly Asp Val Ile Leu Thr Val Ser
    3330                3335                3340                
Ala Thr Asp Glu Asp Gly Pro Leu Asn Ser Asp Ile Thr Tyr Ser Leu
3345                3350                3355                3360
Ile Gly Gly Asn Gln Leu Gly His Phe Thr Ile His Pro Lys Lys Gly
                3365                3370                3375    
Glu Leu Gln Val Ala Lys Ala Leu Asp Arg Glu Gln Ala Ser Ser Tyr
            3380                3385                3390        
Ser Leu Lys Leu Arg Ala Thr Asp Ser Gly Gln Pro Pro Leu His Glu
        3395                3400                3405            
Asp Thr Asp Ile Ala Ile Gln Val Ala Asp Val Asn Asp Asn Pro Pro
    3410                3415                3420                
Arg Phe Phe Gln Leu Asn Tyr Ser Thr Thr Val Gln Glu Asn Ser Pro
3425                3430                3435                3440
Ile Gly Ser Lys Val Leu Gln Leu Ile Leu Ser Asp Pro Asp Ser Pro
                3445                3450                3455    
Glu Asn Gly Pro Pro Tyr Ser Phe Arg Ile Thr Lys Gly Asn Asn Gly
            3460                3465                3470        
Ser Ala Phe Arg Val Thr Pro Asp Gly Trp Leu Val Thr Ala Glu Gly
        3475                3480                3485            
Leu Ser Arg Arg Ala Gln Glu Trp Tyr Gln Leu Gln Ile Gln Ala Ser
    3490                3495                3500                
Asp Ser Gly Ile Pro Pro Leu Ser Ser Leu Thr Ser Val Arg Val His
3505                3510                3515                3520
Val Thr Glu Gln Ser His Tyr Ala Pro Ser Ala Leu Pro Leu Glu Ile
                3525                3530                3535    
Phe Ile Thr Val Gly Glu Asp Glu Phe Gln Gly Gly Met Val Gly Lys
            3540                3545                3550        
Ile His Ala Thr Asp Arg Asp Pro Gln Asp Thr Leu Thr Tyr Ser Leu
        3555                3560                3565            
Ala Glu Glu Glu Thr Leu Gly Arg His Phe Ser Val Gly Ala Pro Asp
    3570                3575                3580                
Gly Lys Ile Ile Ala Ala Gln Gly Leu Pro Arg Gly His Tyr Ser Phe
3585                3590                3595                3600
Asn Val Thr Val Ser Asp Gly Thr Phe Thr Thr Thr Ala Gly Val His
                3605                3610                3615    
Val Tyr Val Trp His Val Gly Gln Glu Ala Leu Gln Gln Ala Met Trp
            3620                3625                3630        
Met Gly Phe Tyr Gln Leu Thr Pro Glu Glu Leu Val Ser Asp His Trp
        3635                3640                3645            
Arg Asn Leu Gln Arg Phe Leu Ser His Lys Leu Asp Ile Lys Arg Ala
    3650                3655                3660                
Asn Ile His Leu Ala Ser Leu Gln Pro Ala Glu Ala Val Ala Gly Val
3665                3670                3675                3680
Asp Val Leu Leu Val Phe Glu Gly His Ser Gly Thr Phe Tyr Glu Phe
                3685                3690                3695    
Gln Glu Leu Ala Ser Ile Ile Thr His Ser Ala Lys Glu Met Glu His
            3700                3705                3710        
Ser Val Gly Val Gln Met Arg Ser Ala Met Pro Met Val Pro Cys Gln
        3715                3720                3725            
Gly Pro Thr Cys Gln Gly Gln Ile Cys His Asn Thr Val His Leu Asp
    3730                3735                3740                
Pro Lys Val Gly Pro Thr Tyr Ser Thr Ala Arg Leu Ser Ile Leu Thr
3745                3750                3755                3760
Pro Arg His His Leu Gln Arg Ser Cys Ser Cys Asn Gly Thr Ala Thr
                3765                3770                3775    
Arg Phe Ser Gly Gln Ser Tyr Val Arg Tyr Arg Ala Pro Ala Ala Arg
            3780                3785                3790        
Asn Trp His Ile His Phe Tyr Leu Lys Thr Leu Gln Pro Gln Ala Ile
        3795                3800                3805            
Leu Leu Phe Thr Asn Glu Thr Ala Ser Val Ser Leu Lys Leu Ala Ser
    3810                3815                3820                
Gly Val Pro Gln Leu Glu Tyr His Cys Leu Gly Gly Phe Tyr Gly Asn
3825                3830                3835                3840
Leu Ser Ser Gln Arg His Val Asn Asp His Glu Trp His Ser Ile Leu
                3845                3850                3855    
Val Glu Glu Met Asp Ala Ser Ile Arg Leu Met Val Asp Ser Met Gly
            3860                3865                3870        
Asn Thr Ser Leu Val Val Pro Glu Asn Cys Arg Gly Leu Arg Pro Glu
        3875                3880                3885            
Arg His Leu Leu Leu Gly Gly Leu Ile Leu Leu His Ser Ser Ser Asn
    3890                3895                3900                
Val Ser Gln Gly Phe Glu Gly Cys Leu Asp Ala Val Val Val Asn Glu
3905                3910                3915                3920
Glu Ala Leu Asp Leu Leu Ala Pro Gly Lys Thr Val Ala Gly Leu Leu
                3925                3930                3935    
Glu Thr Gln Ala Leu Thr Gln Cys Cys Leu His Ser Asp Tyr Cys Ser
            3940                3945                3950        
Gln Asn Thr Cys Leu Asn Gly Gly Lys Cys Ser Trp Thr His Gly Ala
        3955                3960                3965            
Gly Tyr Val Cys Lys Cys Pro Pro Gln Phe Ser Gly Lys His Cys Glu
    3970                3975                3980                
Gln Gly Arg Glu Asn Cys Thr Phe Ala Pro Cys Leu Glu Gly Gly Thr
3985                3990                3995                4000
Cys Ile Leu Ser Pro Lys Gly Ala Ser Cys Asn Cys Pro His Pro Tyr
                4005                4010                4015    
Thr Gly Asp Arg Cys Glu Met Glu Ala Arg Gly Cys Ser Glu Gly His
            4020                4025                4030        
Cys Leu Val Thr Pro Glu Ile Gln Arg Gly Asp Trp Gly Gln Gln Glu
        4035                4040                4045            
Leu Leu Ile Ile Thr Val Ala Val Ala Phe Ile Ile Ile Ser Thr Val
    4050                4055                4060                
Gly Leu Leu Phe Tyr Cys Arg Arg Cys Lys Ser His Lys Pro Val Ala
4065                4070                4075                4080
Met Glu Asp Pro Asp Leu Leu Ala Arg Ser Val Gly Val Asp Thr Gln
                4085                4090                4095    
Ala Met Pro Ala Ile Glu Leu Asn Pro Leu Ser Ala Ser Ser Cys Asn
            4100                4105                4110        
Asn Leu Asn Gln Pro Glu Pro Ser Lys Ala Ser Val Pro Asn Glu Leu
        4115                4120                4125            
Val Thr Phe Gly Pro Asn Ser Lys Gln Arg Pro Val Val Cys Ser Val
    4130                4135                4140                
Pro Pro Arg Leu Pro Pro Ala Ala Val Pro Ser His Ser Asp Asn Glu
4145                4150                4155                4160
Pro Val Ile Lys Arg Thr Trp Ser Ser Glu Glu Met Val Tyr Pro Gly
                4165                4170                4175    
Gly Ala Met Val Trp Pro Pro Thr Tyr Ser Arg Asn Glu Arg Trp Glu
            4180                4185                4190        
Tyr Pro His Ser Glu Val Thr Gln Gly Pro Leu Pro Pro Ser Ala His
        4195                4200                4205            
Arg His Ser Thr Pro Val Val Met Pro Glu Pro Asn Gly Leu Tyr Gly
    4210                4215                4220                
Gly Phe Pro Phe Pro Leu Glu Met Glu Asn Lys Arg Ala Pro Leu Pro
4225                4230                4235                4240
Pro Arg Tyr Ser Asn Gln Asn Leu Glu Asp Leu Met Pro Ser Arg Pro
                4245                4250                4255    
Pro Ser Pro Arg Glu Arg Leu Val Ala Pro Cys Leu Asn Glu Tyr Thr
            4260                4265                4270        
Ala Ile Ser Tyr Tyr His Ser Gln Phe Arg Gln Gly Gly Gly Gly Pro
        4275                4280                4285            
Cys Leu Ala Asp Gly Gly Tyr Lys Gly Val Gly Met Arg Leu Ser Arg
    4290                4295                4300                
Ala Gly Pro Ser Tyr Ala Val Cys Glu Val Glu Gly Ala Pro Leu Ala
4305                4310                4315                4320
Gly Gln Gly Gln Pro Arg Val Pro Pro Asn Tyr Glu Gly Ser Asp Met
                4325                4330                4335    
Val Glu Ser Asp Tyr Gly Ser Cys Glu Glu Val Met Phe
            4340                4345                


<210> 1740
<211> 207
<212> PRT
<213> Homo sapiens

<400> 1740
Met Thr Ser Arg Lys Lys Val Leu Leu Lys Val Ile Ile Leu Gly Asp
 1               5                  10                  15      
Ser Gly Val Gly Lys Thr Ser Leu Met Asn Gln Tyr Val Asn Lys Lys
            20                  25                  30          
Phe Ser Asn Gln Tyr Lys Ala Thr Ile Gly Ala Asp Phe Leu Thr Lys
        35                  40                  45              
Glu Val Met Val Asp Asp Arg Leu Val Thr Met Gln Ile Trp Asp Thr
    50                  55                  60                  
Ala Gly Gln Glu Arg Phe Gln Ser Leu Gly Val Ala Phe Tyr Arg Gly
65                  70                  75                  80  
Ala Asp Cys Cys Val Leu Val Phe Asp Val Thr Ala Pro Asn Thr Phe
                85                  90                  95      
Lys Thr Leu Asp Ser Trp Arg Asp Glu Phe Leu Val Gln Ala Ser Pro
            100                 105                 110         
Arg Asp Pro Glu Asn Phe Pro Phe Val Val Leu Gly Asn Lys Val Asp
        115                 120                 125             
Leu Glu Asn Arg Gln Val Ala Thr Lys Arg Ala Gln Ala Trp Cys Tyr
    130                 135                 140                 
Ser Lys Asn Asn Ile Pro Tyr Phe Glu Thr Ser Ala Lys Glu Ala Ile
145                 150                 155                 160 
Asn Val Glu Gln Ala Phe Gln Thr Ile Ala Arg Asn Ala Leu Lys Gln
                165                 170                 175     
Glu Thr Glu Val Glu Leu Tyr Asn Glu Phe Pro Glu Pro Ile Lys Leu
            180                 185                 190         
Asp Lys Asn Asp Arg Ala Lys Ala Ser Ala Glu Ser Cys Ser Cys
        195                 200                 205         


<210> 1741
<211> 673
<212> PRT
<213> Homo sapiens

<400> 1741
Ser Leu Asn Pro Leu Cys Phe Glu Cys Gly Gln Gln His Trp Thr Arg
 1               5                  10                  15      
Glu Asn His Leu Tyr Asn Tyr Gln Asn Glu Val Asp Asp Asp Leu Val
            20                  25                  30          
Cys His Ile Cys Leu Gln Pro Leu Leu Gln Pro Leu Asp Thr Pro Cys
        35                  40                  45              
Gly His Thr Phe Cys Tyr Lys Cys Leu Arg Asn Phe Leu Gln Glu Lys
    50                  55                  60                  
Asp Phe Cys Pro Leu Asp Arg Lys Arg Leu His Phe Lys Leu Cys Lys
65                  70                  75                  80  
Lys Ser Ser Ile Leu Val His Lys Leu Leu Asp Lys Leu Leu Val Leu
                85                  90                  95      
Cys Pro Phe Ser Ser Val Cys Lys Asp Val Met Gln Arg Cys Asp Leu
            100                 105                 110         
Glu Ala His Leu Lys Asn Arg Cys Pro Gly Ala Ser His Arg Arg Val
        115                 120                 125             
Ala Leu Glu Arg Arg Lys Thr Ser Arg Thr Gln Ala Glu Ile Glu Asn
    130                 135                 140                 
Glu Asn Gly Pro Thr Leu Leu Asp Pro Ala Gly Thr Leu Ser Pro Glu
145                 150                 155                 160 
Ala Asp Cys Leu Gly Thr Gly Ala Val Pro Val Glu Arg His Leu Thr
                165                 170                 175     
Ser Ala Ser Leu Ser Thr Trp Ser Glu Glu Pro Gly Leu Asp Asn Pro
            180                 185                 190         
Ala Phe Glu Glu Ser Ala Gly Ala Asp Thr Thr Gln Gln Pro Leu Ser
        195                 200                 205             
Leu Pro Glu Gly Glu Ile Thr Thr Ile Glu Ile His Arg Ser Asn Pro
    210                 215                 220                 
Tyr Ile Gln Leu Gly Ile Ser Ile Val Gly Gly Asn Glu Thr Pro Leu
225                 230                 235                 240 
Ile Asn Ile Val Ile Gln Glu Val Tyr Arg Asp Gly Val Ile Ala Arg
                245                 250                 255     
Asp Gly Arg Leu Leu Ala Gly Asp Gln Ile Leu Gln Val Asn Asn Tyr
            260                 265                 270         
Asn Ile Ser Asn Val Ser His Asn Tyr Ala Arg Ala Val Leu Ser Gln
        275                 280                 285             
Pro Cys Asn Thr Leu His Leu Thr Val Leu Arg Glu Arg Arg Phe Gly
    290                 295                 300                 
Asn Arg Ala His Asn His Ser Asp Ser Asn Ser Pro Arg Glu Glu Ile
305                 310                 315                 320 
Phe Gln Val Ala Leu His Lys Arg Asp Ser Gly Glu Gln Leu Gly Ile
                325                 330                 335     
Lys Leu Val Arg Arg Thr Asp Glu Pro Gly Val Phe Ile Leu Asp Leu
            340                 345                 350         
Leu Glu Gly Gly Leu Ala Ala Gln Asp Gly Arg Leu Ser Ser Asn Asp
        355                 360                 365             
Arg Val Leu Ala Ile Asn Gly His Asp Leu Lys Tyr Gly Thr Pro Glu
    370                 375                 380                 
Leu Ala Ala Gln Ile Ile Gln Ala Ser Gly Glu Arg Val Asn Leu Thr
385                 390                 395                 400 
Ile Ala Arg Pro Gly Lys Pro Gln Pro Gly Asn Thr Ile Arg Glu Ala
                405                 410                 415     
Gly Asn His Ser Ser Ser Ser Gln His His Thr Pro Pro Pro Tyr Tyr
            420                 425                 430         
Ser Arg Pro Ser Ser His Lys Asp Leu Thr Gln Cys Val Thr Cys Gln
        435                 440                 445             
Glu Lys His Ile Thr Val Lys Lys Glu Pro His Glu Ser Leu Gly Met
    450                 455                 460                 
Thr Val Ala Gly Gly Arg Gly Ser Lys Ser Gly Glu Leu Pro Ile Phe
465                 470                 475                 480 
Val Thr Ser Val Pro Pro His Gly Cys Leu Ala Arg Asp Gly Arg Ile
                485                 490                 495     
Lys Arg Gly Asp Val Leu Leu Asn Ile Asn Gly Ile Asp Leu Thr Asn
            500                 505                 510         
Leu Ser His Ser Glu Ala Val Ala Met Leu Lys Ala Ser Ala Ala Ser
        515                 520                 525             
Pro Ala Val Ala Leu Lys Ala Leu Glu Val Gln Ile Val Glu Glu Ala
    530                 535                 540                 
Thr Gln Asn Ala Glu Glu Gln Pro Ser Thr Phe Ser Glu Asn Glu Tyr
545                 550                 555                 560 
Asp Ala Ser Trp Ser Pro Ser Trp Val Met Trp Leu Gly Leu Pro Ser
                565                 570                 575     
Thr Leu His Ser Cys His Asp Ile Val Leu Arg Arg Ser Tyr Leu Gly
            580                 585                 590         
Ser Trp Gly Phe Ser Ile Val Gly Gly Tyr Glu Glu Asn His Thr Asn
        595                 600                 605             
Gln Pro Phe Phe Ile Lys Thr Ile Val Leu Gly Thr Pro Ala Tyr Tyr
    610                 615                 620                 
Asp Gly Arg Leu Lys Cys Gly Asp Met Ile Val Ala Val Asn Gly Leu
625                 630                 635                 640 
Ser Thr Val Gly Met Ser His Ser Ala Leu Val Pro Met Leu Lys Glu
                645                 650                 655     
Gln Arg Asn Lys Val Thr Leu Thr Val Ile Cys Trp Pro Gly Ser Leu
            660                 665                 670         
Val
    


<210> 1742
<211> 484
<212> PRT
<213> Homo sapiens

<400> 1742
Met Asn Gln Val Val Gln Pro Leu Met Ser Arg His Ser Ala Cys Arg
 1               5                  10                  15      
Gly Ser Gln Ala His Leu Ser Trp Val Asp Lys Gly Asp Leu Val Ala
            20                  25                  30          
Leu Ser Leu Pro Ala Gly His Gly Asp Thr Asp Gly Pro Ile Ser Leu
        35                  40                  45              
Asp Val Pro Asp Gly Ala Pro Asp Pro Gln Arg Thr Lys Ala Ala Ile
    50                  55                  60                  
Asp His Leu His Gln Lys Ile Leu Lys Ile Thr Glu Gln Ile Lys Ile
65                  70                  75                  80  
Glu Gln Glu Ala Arg Asp Asp Asn Val Ala Glu Tyr Leu Lys Leu Ala
                85                  90                  95      
Asn Asn Ala Asp Lys Gln Gln Val Ser Arg Ile Lys Gln Val Phe Glu
            100                 105                 110         
Lys Lys Asn Gln Lys Ser Ala Gln Thr Ile Ala Gln Leu His Lys Lys
        115                 120                 125             
Leu Glu His Tyr Arg Arg Arg Leu Lys Glu Ile Glu Gln Asn Gly Pro
    130                 135                 140                 
Ser Arg Gln Pro Lys Asp Val Leu Arg Asp Met Gln Gln Gly Leu Lys
145                 150                 155                 160 
Asp Val Gly Ala Asn Val Arg Ala Gly Ile Ser Gly Phe Gly Gly Gly
                165                 170                 175     
Val Val Glu Gly Val Lys Gly Ser Leu Ser Gly Leu Ser Gln Ala Thr
            180                 185                 190         
His Thr Ala Val Val Ser Lys Pro Arg Glu Phe Ala Ser Leu Ile Arg
        195                 200                 205             
Asn Lys Phe Gly Ser Ala Asp Asn Ile Ala His Leu Lys Asp Pro Leu
    210                 215                 220                 
Glu Asp Gly Pro Pro Glu Glu Ala Ala Arg Ala Leu Ser Gly Ser Ala
225                 230                 235                 240 
Thr Leu Val Ser Ser Pro Lys Tyr Gly Ser Asp Asp Glu Cys Ser Ser
                245                 250                 255     
Ala Ser Ala Ser Ser Ala Gly Ala Gly Ser Asn Ser Gly Ala Gly Pro
            260                 265                 270         
Gly Gly Ala Leu Gly Ser Pro Lys Ser Asn Ala Leu Tyr Gly Ala Pro
        275                 280                 285             
Gly Asn Leu Asp Ala Leu Leu Glu Glu Leu Arg Glu Ile Lys Glu Gly
    290                 295                 300                 
Gln Ser His Leu Glu Asp Ser Met Glu Asp Leu Lys Thr Gln Leu Gln
305                 310                 315                 320 
Arg Asp Tyr Thr Tyr Met Thr Gln Cys Leu Gln Glu Glu Arg Tyr Arg
                325                 330                 335     
Tyr Glu Arg Leu Glu Glu Gln Leu Asn Asp Leu Thr Glu Leu His Gln
            340                 345                 350         
Asn Glu Met Thr Asn Leu Lys Gln Glu Leu Ala Ser Met Glu Glu Lys
        355                 360                 365             
Val Ala Tyr Gln Ser Tyr Glu Arg Ala Arg Asp Ile Gln Glu Ala Val
    370                 375                 380                 
Glu Ser Cys Leu Thr Arg Val Thr Lys Leu Glu Leu Gln Gln Gln Gln
385                 390                 395                 400 
Gln Gln Val Val Gln Leu Glu Gly Val Glu Asn Ala Asn Ala Arg Ala
                405                 410                 415     
Leu Leu Gly Lys Phe Ile Asn Val Ile Leu Ala Leu Met Ala Val Leu
            420                 425                 430         
Leu Val Phe Val Ser Thr Ile Ala Asn Phe Ile Thr Pro Leu Met Lys
        435                 440                 445             
Thr Arg Leu Arg Ile Thr Ser Thr Thr Leu Leu Val Leu Val Leu Phe
    450                 455                 460                 
Leu Leu Trp Lys His Trp Asp Ser Leu Thr Tyr Leu Leu Glu His Val
465                 470                 475                 480 
Leu Leu Pro Ser
                


<210> 1743
<211> 5065
<212> PRT
<213> Homo sapiens

<400> 1743
Met Ala Ala Thr Leu Gly Ala Gly Thr Pro Pro Arg Pro Gln Ala Arg
 1               5                  10                  15      
Ser Ile Ala Gly Val Tyr Val Glu Ala Ser Gly Gln Ala Gln Ser Val
            20                  25                  30          
Tyr Ala Ala Met Glu Gln Gly Leu Leu Pro Ala Gly Leu Gly Gln Ala
        35                  40                  45              
Leu Leu Glu Ala Gln Ala Ala Thr Gly Gly Leu Val Asp Leu Ala Arg
    50                  55                  60                  
Gly Gln Leu Leu Pro Val Ser Lys Ala Leu Gln Gln Gly Leu Val Gly
65                  70                  75                  80  
Leu Glu Leu Lys Glu Lys Leu Leu Ala Ala Glu Arg Ala Thr Thr Gly
                85                  90                  95      
Tyr Pro Asp Pro Tyr Gly Gly Glu Lys Leu Ala Leu Phe Gln Ala Ile
            100                 105                 110         
Gly Lys Glu Val Val Asp Arg Ala Leu Gly Gln Ser Trp Leu Glu Val
        115                 120                 125             
Gln Leu Ala Thr Gly Gly Leu Val Asp Pro Ala Gln Gly Val Leu Val
    130                 135                 140                 
Ala Pro Glu Pro Ala Cys His Gln Gly Leu Leu Asp Arg Glu Thr Trp
145                 150                 155                 160 
His Lys Leu Ser Glu Leu Glu Pro Gly Thr Gly Asp Leu Arg Phe Leu
                165                 170                 175     
Asn Pro Asn Thr Leu Glu Arg Leu Thr Tyr His Gln Leu Leu Glu Arg
            180                 185                 190         
Cys Val Arg Ala Pro Gly Ser Gly Leu Ala Leu Leu Pro Leu Lys Ile
        195                 200                 205             
Thr Phe Arg Ser Met Gly Gly Ala Val Ser Ala Ala Glu Leu Leu Glu
    210                 215                 220                 
Val Gly Ile Leu Asp Glu Gln Ala Val Gln Gly Leu Arg Glu Gly Arg
225                 230                 235                 240 
Leu Ala Ala Val Asp Val Ser Ala Arg Ala Glu Val Arg Arg Tyr Leu
                245                 250                 255     
Glu Gly Thr Gly Ser Val Ala Gly Val Val Leu Leu Pro Glu Gly His
            260                 265                 270         
Lys Lys Ser Phe Phe Gln Ala Ala Thr Glu His Leu Leu Pro Met Gly
        275                 280                 285             
Thr Ala Leu Pro Leu Leu Glu Ala Gln Ala Ala Thr His Thr Leu Val
    290                 295                 300                 
Asp Pro Ile Thr Gly Gln Arg Leu Trp Val Asp Glu Ala Val Arg Ala
305                 310                 315                 320 
Gly Leu Val Ser Pro Glu Leu His Glu Gln Leu Leu Val Ala Glu Gln
                325                 330                 335     
Ala Val Thr Gly His His Asp Pro Phe Ser Gly Ser Gln Ile Pro Leu
            340                 345                 350         
Phe Gln Ala Met Lys Lys Gly Leu Val Asp Arg Pro Leu Ala Leu Arg
        355                 360                 365             
Leu Leu Asp Ala Gln Leu Ala Thr Gly Gly Leu Val Cys Pro Ala Arg
    370                 375                 380                 
Arg Leu Arg Leu Pro Leu Glu Ala Ala Leu Arg Cys Gly Cys Leu Asp
385                 390                 395                 400 
Glu Asp Thr Gln Arg Gln Leu Ser Gln Ala Gly Ser Phe Ser Asp Gly
                405                 410                 415     
Thr His Gly Gly Leu Arg Tyr Glu Gln Leu Leu Ala Leu Cys Val Thr
            420                 425                 430         
Asp Pro Glu Thr Gly Leu Ala Phe Leu Pro Leu Ser Gly Gly Pro Arg
        435                 440                 445             
Gly Gly Glu Pro Gln Gly Pro Pro Phe Ile Lys Tyr Ser Thr Arg Gln
    450                 455                 460                 
Ala Leu Ser Thr Ala Thr Ala Thr Val Ser Val Gly Lys Phe Arg Gly
465                 470                 475                 480 
Arg Pro Val Ser Leu Trp Glu Leu Leu Phe Ser Glu Ala Ile Ser Ser
                485                 490                 495     
Glu Gln Arg Ala Met Leu Ala Gln Gln Tyr Gln Glu Gly Thr Leu Ser
            500                 505                 510         
Val Glu Lys Leu Ala Ala Glu Leu Ser Ala Thr Leu Glu Gln Ala Ala
        515                 520                 525             
Ala Thr Ala Arg Val Thr Phe Ser Gly Leu Arg Asp Thr Val Thr Pro
    530                 535                 540                 
Gly Glu Leu Leu Lys Ala Glu Ile Ile Asp Gln Asp Leu Tyr Glu Arg
545                 550                 555                 560 
Leu Glu His Gly Gln Ala Thr Ala Lys Asp Val Gly Ser Leu Ala Ser
                565                 570                 575     
Ala Gln Arg Tyr Leu Gln Gly Thr Gly Cys Ile Ala Gly Leu Leu Leu
            580                 585                 590         
Pro Gly Ser Gln Glu Arg Leu Ser Ile Tyr Glu Ala Arg Cys Lys Gly
        595                 600                 605             
Leu Leu Arg Pro Gly Thr Ala Leu Ile Leu Leu Glu Ala Gln Ala Ala
    610                 615                 620                 
Thr Gly Phe Ile Ile Asp Pro Lys Ala Asn Lys Gly His Ser Val Glu
625                 630                 635                 640 
Glu Ala Leu Arg Ala Ala Val Ile Gly Pro Asp Val Phe Ala Lys Leu
                645                 650                 655     
Leu Ser Ala Glu Arg Ala Val Thr Gly Tyr Thr Asp Pro Tyr Thr Gly
            660                 665                 670         
Gln Gln Ile Ser Leu Phe Gln Ala Met Gln Lys Gly Leu Ile Val Arg
        675                 680                 685             
Glu His Gly Ile Arg Leu Leu Glu Ala Gln Ile Ala Thr Gly Gly Val
    690                 695                 700                 
Ile Asp Pro Val His Ser His Arg Val Pro Val Asp Val Ala Tyr Arg
705                 710                 715                 720 
Arg Gly Tyr Phe Asp Gln Met Leu Asn Leu Ile Leu Leu Asp Pro Ser
                725                 730                 735     
Asp Asp Thr Lys Gly Phe Phe Asp Pro Asn Thr His Glu Asn Leu Thr
            740                 745                 750         
Tyr Leu Gln Leu Leu Glu Arg Cys Val Arg Asp Pro Glu Thr Gly Leu
        755                 760                 765             
Tyr Leu Leu Pro Leu Ser Ser Thr Gln Ser Pro Leu Val Asp Ser Ala
    770                 775                 780                 
Thr Gln Gln Ala Phe Gln Asn Leu Leu Leu Ser Val Lys Tyr Gly Arg
785                 790                 795                 800 
Phe Gln Gly Gln Arg Val Ser Ala Trp Glu Leu Ile Asn Ser Glu Tyr
                805                 810                 815     
Phe Ser Glu Gly Arg Arg Arg Gln Leu Leu Arg Arg Tyr Arg Gln Arg
            820                 825                 830         
Glu Val Thr Leu Gly Gln Val Ala Lys Leu Leu Glu Ala Glu Thr Gln
        835                 840                 845             
Arg Gln Ala Asp Ile Met Leu Pro Ala Leu Arg Ser Arg Val Thr Val
    850                 855                 860                 
His Gln Leu Leu Glu Ala Gly Ile Ile Asp Gln Gln Leu Leu Asp Gln
865                 870                 875                 880 
Val Leu Ala Gly Thr Ile Ser Pro Glu Ala Leu Leu Leu Met Asp Gly
                885                 890                 895     
Val Arg Arg Tyr Leu Cys Gly Leu Gly Ala Val Gly Gly Val Arg Leu
            900                 905                 910         
Leu Pro Ser Gly Gln Arg Leu Ser Leu Tyr Gln Ala Met Arg Gln Lys
        915                 920                 925             
Leu Leu Gly Pro Arg Val Ala Leu Ala Leu Leu Glu Ala Gln Ala Ala
    930                 935                 940                 
Thr Gly Thr Ile Met Asp Pro His Ser Pro Glu Ser Leu Ser Val Asp
945                 950                 955                 960 
Glu Ala Val Arg Arg Gly Val Val Gly Pro Glu Leu Tyr Gly Arg Leu
                965                 970                 975     
Lys Arg Ala Glu Gly Ala Ile Ala Gly Phe Arg Asp Pro Phe Ser Gly
            980                 985                 990         
Lys Gln Val Ser Val Phe Gln Ala Met Lys Lys Gly Leu Ile Pro Trp
        995                 1000                1005            
Glu Gln Ala Ala Arg Leu Leu Glu Ala Gln Val Ala Thr Gly Gly Ile
    1010                1015                1020                
Ile Asp Pro Thr Ser His His His Leu Pro Met Pro Val Ala Ile Gln
1025                1030                1035                1040
Arg Gly Tyr Val Asp Gln Glu Met Glu Thr Ala Leu Ser Ser Ser Ser
                1045                1050                1055    
Glu Thr Phe Pro Thr Pro Asp Gly Gln Gly Arg Thr Ser Tyr Ala Gln
            1060                1065                1070        
Leu Leu Glu Glu Cys Pro Arg Asp Glu Thr Ser Gly Leu His Leu Leu
        1075                1080                1085            
Pro Leu Pro Glu Ser Ala Pro Ala Leu Pro Thr Glu Glu Gln Val Gln
    1090                1095                1100                
Arg Ser Leu Gln Ala Val Pro Gly Ala Lys Asp Gly Thr Ser Leu Trp
1105                1110                1115                1120
Asp Leu Leu Ser Ser Cys His Phe Thr Glu Glu Gln Arg Arg Gly Leu
                1125                1130                1135    
Leu Glu Asp Val Gln Glu Gly Arg Thr Thr Val Pro Gln Leu Leu Ala
            1140                1145                1150        
Ser Val Gln Arg Trp Val Gln Glu Thr Lys Leu Leu Ala Gln Ala Arg
        1155                1160                1165            
Val Met Val Pro Gly Pro Arg Gly Glu Val Pro Ala Val Trp Leu Leu
    1170                1175                1180                
Asp Ala Gly Ile Ile Thr Gln Glu Thr Leu Glu Ala Leu Ala Gln Gly
1185                1190                1195                1200
Thr Gln Ser Pro Ala Gln Val Ala Glu Gln Pro Ala Val Lys Ala Cys
                1205                1210                1215    
Leu Trp Gly Thr Gly Cys Val Ala Gly Val Leu Leu Gln Pro Ser Gly
            1220                1225                1230        
Ala Lys Ala Ser Ile Ala Gln Ala Val Arg Asp Gly Leu Leu Pro Thr
        1235                1240                1245            
Gly Leu Gly Gln Arg Leu Leu Glu Ala Gln Val Ala Ser Gly Phe Leu
    1250                1255                1260                
Val Asp Pro Leu Asn Asn Gln Arg Leu Ser Val Glu Asp Ala Val Lys
1265                1270                1275                1280
Val Gly Leu Val Gly Arg Glu Leu Ser Glu Gln Leu Gly Gln Ala Glu
                1285                1290                1295    
Arg Ala Ala Ala Gly Tyr Pro Asp Pro Tyr Ser Arg Ala Ser Leu Ser
            1300                1305                1310        
Leu Trp Gln Ala Met Glu Lys Gly Leu Val Pro Gln Asn Glu Gly Leu
        1315                1320                1325            
Pro Leu Leu Gln Val Gln Leu Ala Thr Gly Gly Val Val Asp Pro Val
    1330                1335                1340                
His Gly Val His Leu Pro Gln Ala Ala Ala Cys Arg Leu Gly Leu Leu
1345                1350                1355                1360
Asp Thr Gln Thr Ser Gln Val Leu Thr Ala Val Asp Lys Asp Asn Lys
                1365                1370                1375    
Phe Phe Phe Asp Pro Ser Ala Arg Asp Gln Val Thr Tyr Gln Gln Leu
            1380                1385                1390        
Arg Glu Arg Cys Val Cys Asp Ser Glu Thr Gly Leu Leu Leu Leu Pro
        1395                1400                1405            
Leu Pro Ser Asp Thr Val Leu Glu Val Asp Asp His Thr Ala Val Ala
    1410                1415                1420                
Leu Arg Ala Met Lys Val Pro Val Ser Thr Gly Arg Phe Lys Gly Cys
1425                1430                1435                1440
Ser Val Ser Leu Trp Asp Leu Leu Leu Ser Glu Tyr Val Gly Ala Asp
                1445                1450                1455    
Lys Arg Arg Glu Leu Val Ala Leu Cys Arg Ser Gly Arg Ala Ala Ala
            1460                1465                1470        
Leu Arg Gln Val Val Ser Ala Val Thr Ala Leu Val Glu Ala Ala Glu
        1475                1480                1485            
Arg Gln Pro Leu Gln Ala Thr Phe Arg Gly Leu Arg Lys Gln Val Ser
    1490                1495                1500                
Ala Arg Asp Leu Phe Arg Ala Gln Leu Ile Ser Arg Lys Thr Leu Asp
1505                1510                1515                1520
Glu Leu Ser Gln Gly Thr Thr Thr Val Lys Glu Val Ala Glu Met Asp
                1525                1530                1535    
Ser Val Lys Arg Ser Leu Glu Gly Gly Asn Phe Ile Ala Gly Val Leu
            1540                1545                1550        
Ile Gln Gly Thr Gln Glu Arg Met Ser Ile Pro Glu Ala Leu Arg Arg
        1555                1560                1565            
His Ile Leu Arg Pro Gly Thr Ala Leu Val Leu Leu Glu Ala Gln Ala
    1570                1575                1580                
Ala Thr Gly Phe Ile Ile Asp Pro Ala Glu Asn Arg Lys Leu Thr Val
1585                1590                1595                1600
Glu Glu Ala Phe Lys Ala Gly Met Phe Gly Lys Glu Thr Tyr Val Lys
                1605                1610                1615    
Leu Leu Ser Ala Glu Arg Ala Val Thr Gly Tyr Thr Asp Pro Tyr Thr
            1620                1625                1630        
Gly Gln Gln Ile Ser Leu Phe Gln Ala Met Gln Lys Asp Leu Ile Val
        1635                1640                1645            
Arg Glu His Gly Ile Arg Leu Leu Glu Ala Gln Ile Ala Thr Gly Gly
    1650                1655                1660                
Ile Ile Asp Pro Val His Ser His Arg Val Pro Val Asp Val Ala Tyr
1665                1670                1675                1680
Arg Cys Gly Tyr Phe Asp Glu Glu Met Asn Arg Ile Leu Ala Asp Pro
                1685                1690                1695    
Ser Asp Asp Thr Lys Gly Phe Phe Asp Pro Asn Thr His Glu Asn Leu
            1700                1705                1710        
Thr Tyr Leu Gln Leu Leu Glu Arg Cys Val Glu Asp Pro Glu Thr Gly
        1715                1720                1725            
Leu Tyr Leu Leu Gln Ile Ile Lys Lys Gly Glu Asn Tyr Val Tyr Ile
    1730                1735                1740                
Asn Glu Ala Thr Arg His Val Leu Gln Ser Arg Thr Ala Lys Met Arg
1745                1750                1755                1760
Val Gly Arg Phe Ala Asp Gln Val Val Ser Phe Trp Asp Leu Leu Ser
                1765                1770                1775    
Ser Pro Tyr Phe Thr Glu Asp Arg Lys Arg Glu Leu Ile Gln Glu Tyr
            1780                1785                1790        
Gly Ala Gln Ser Gly Gly Leu Glu Lys Leu Leu Glu Ile Ile Thr Thr
        1795                1800                1805            
Thr Ile Glu Glu Thr Glu Thr Gln Asn Gln Gly Ile Lys Val Ala Ala
    1810                1815                1820                
Ile Arg Gly Glu Val Thr Ala Ala Asp Leu Phe Asn Ser Arg Val Ile
1825                1830                1835                1840
Asp Gln Lys Thr Leu His Thr Leu Arg Val Gly Arg Thr Gly Gly Gln
                1845                1850                1855    
Ala Leu Ser Thr Leu Glu Cys Val Lys Pro Tyr Leu Glu Gly Ser Asp
            1860                1865                1870        
Cys Ile Ala Gly Val Thr Val Pro Ser Thr Arg Glu Val Met Ser Leu
        1875                1880                1885            
His Glu Ala Ser Arg Lys Glu Leu Ile Pro Ala Ala Phe Ala Thr Trp
    1890                1895                1900                
Leu Leu Glu Ala Gln Ala Ala Thr Gly Phe Leu Leu Asp Pro Cys Thr
1905                1910                1915                1920
Arg Gln Lys Leu Ser Val Asp Glu Ala Val Asp Val Gly Leu Val Asn
                1925                1930                1935    
Glu Glu Leu Arg Glu Arg Leu Leu Lys Ala Glu Arg Ala Ala Thr Gly
            1940                1945                1950        
Tyr Arg Asp Pro Ala Thr Gly Asp Thr Ile Pro Leu Phe Gln Ala Met
        1955                1960                1965            
Gln Lys Gln Leu Ile Glu Lys Ala Glu Ala Leu Arg Leu Leu Glu Val
    1970                1975                1980                
Gln Val Ala Thr Gly Gly Val Ile Asp Pro Gln His His His Arg Leu
1985                1990                1995                2000
Pro Leu Glu Thr Ala Tyr Arg Arg Gly Cys Leu His Lys Asp Ile Tyr
                2005                2010                2015    
Ala Leu Ile Ser Asp Gln Lys His Met Arg Lys Arg Phe Val Asp Pro
            2020                2025                2030        
Asn Thr Gln Glu Lys Val Ser Tyr Arg Glu Leu Gln Glu Arg Cys Arg
        2035                2040                2045            
Pro Gln Glu Asp Thr Gly Trp Val Leu Phe Pro Val Asn Lys Ala Ala
    2050                2055                2060                
Arg Asp Ser Glu His Ile Asp Asp Glu Thr Arg Arg Ala Leu Glu Ala
2065                2070                2075                2080
Glu Gln Val Glu Ile Thr Val Gly Arg Phe Arg Gly Gln Lys Pro Thr
                2085                2090                2095    
Leu Trp Ala Leu Leu Asn Ser Glu Tyr Val Thr Glu Glu Lys Lys Leu
            2100                2105                2110        
Gln Leu Val Arg Met Tyr Arg Thr His Thr Arg Arg Ala Leu Gln Thr
        2115                2120                2125            
Val Ala Gln Leu Ile Leu Glu Leu Ile Glu Lys Gln Glu Thr Ser Asn
    2130                2135                2140                
Lys His Leu Trp Phe Gln Gly Ile Arg Arg Gln Ile Thr Ala Ser Glu
2145                2150                2155                2160
Leu Leu Ser Ser Ala Ile Ile Thr Glu Glu Met Leu Gln Asp Leu Glu
                2165                2170                2175    
Thr Gly Arg Ser Thr Thr Gln Glu Leu Met Glu Asp Asp Arg Val Lys
            2180                2185                2190        
Arg Tyr Leu Glu Gly Thr Ser Cys Ile Ala Gly Val Leu Val Pro Ala
        2195                2200                2205            
Lys Asp Gln Pro Gly Arg Gln Glu Lys Met Ser Ile Tyr Gln Ala Met
    2210                2215                2220                
Trp Lys Gly Val Leu Arg Pro Gly Thr Ala Leu Val Leu Leu Glu Ala
2225                2230                2235                2240
Gln Ala Ala Thr Gly Phe Val Ile Asp Pro Val Arg Asn Leu Arg Leu
                2245                2250                2255    
Ser Val Glu Glu Pro Val Pro Ala Gly Val Val Gly Ser Glu Ile Gln
            2260                2265                2270        
Glu Lys Leu Leu Ser Ala Glu Arg Ala Val Thr Gly Tyr Thr Asp Pro
        2275                2280                2285            
Tyr Thr Gly Gln Gln Ile Ser Leu Phe Gln Ala Met Gln Lys Asp Leu
    2290                2295                2300                
Ile Val Arg Glu His Gly Ile Arg Leu Leu Glu Ala Gln Ile Ala Thr
2305                2310                2315                2320
Gly Gly Val Ile Asp Pro Val His Ser His Arg Val Pro Val Asp Val
                2325                2330                2335    
Ala Tyr Arg Arg Gly Tyr Phe Asp Glu Glu Met Asn Arg Val Leu Ala
            2340                2345                2350        
Asp Pro Ser Asp Asp Thr Lys Gly Phe Phe Asp Pro Asn Thr His Glu
        2355                2360                2365            
Asn Leu Thr Tyr Val Gln Leu Leu Arg Arg Cys Val Pro Asp Pro Asp
    2370                2375                2380                
Thr Gly Leu Tyr Met Leu Gln Leu Ala Gly Arg Gly Ser Ala Val His
2385                2390                2395                2400
Gln Leu Ser Glu Glu Leu Arg Cys Ala Leu Arg Asp Ala Arg Val Thr
                2405                2410                2415    
Pro Gly Ser Gly Ala Leu Gln Gly Gln Ser Val Ser Val Trp Glu Leu
            2420                2425                2430        
Leu Phe Tyr Arg Glu Val Ser Glu Asp Arg Arg Gln Asp Leu Leu Ser
        2435                2440                2445            
Arg Tyr Arg Ala Gly Thr Leu Thr Val Glu Glu Leu Gly Ala Thr Leu
    2450                2455                2460                
Thr Ser Leu Leu Ala Gln Ala Gln Ala Gln Ala Arg Ala Glu Ala Glu
2465                2470                2475                2480
Ala Gly Ser Pro Arg Pro Asp Pro Arg Glu Ala Leu Arg Ala Ala Thr
                2485                2490                2495    
Met Glu Val Lys Val Gly Arg Leu Arg Gly Arg Ala Val Pro Val Trp
            2500                2505                2510        
Asp Val Leu Ala Ser Gly Tyr Val Ser Arg Ala Ala Arg Glu Glu Leu
        2515                2520                2525            
Leu Ala Glu Phe Gly Ser Gly Thr Leu Asp Leu Pro Ala Leu Thr Arg
    2530                2535                2540                
Arg Leu Thr Ala Ile Ile Glu Glu Ala Glu Glu Ala Pro Gly Ala Arg
2545                2550                2555                2560
Pro Gln Leu Gln Asp Ala Arg Arg Gly Pro Arg Glu Pro Gly Pro Ala
                2565                2570                2575    
Gly Arg Gly Asp Gly Asp Ser Gly Arg Ser Gln Arg Glu Gly Gln Gly
            2580                2585                2590        
Glu Gly Glu Thr Gln Glu Ala Ala Ala Ala Ala Ala Ala Ala Arg Arg
        2595                2600                2605            
Gln Glu Gln Thr Leu Arg Asp Ala Thr Met Glu Val Gln Arg Gly Gln
    2610                2615                2620                
Phe Gln Gly Arg Pro Val Ser Val Trp Asp Val Leu Phe Ser Ser Tyr
2625                2630                2635                2640
Leu Ser Glu Ala Arg Arg Asp Glu Leu Leu Ala Gln His Ala Ala Gly
                2645                2650                2655    
Ala Leu Gly Leu Pro Asp Leu Val Ala Val Leu Thr Arg Val Ile Glu
            2660                2665                2670        
Glu Thr Glu Glu Arg Leu Ser Lys Val Ser Phe Arg Gly Leu Arg Arg
        2675                2680                2685            
Gln Val Ser Ala Ser Glu Leu His Thr Ser Gly Ile Leu Gly Pro Glu
    2690                2695                2700                
Thr Leu Arg Asp Leu Ala Gln Gly Thr Lys Thr Leu Gln Glu Val Thr
2705                2710                2715                2720
Glu Met Asp Ser Val Lys Arg Tyr Leu Glu Gly Thr Ser Cys Ile Ala
                2725                2730                2735    
Gly Val Leu Val Pro Ala Lys Asp Gln Pro Gly Arg Gln Glu Lys Met
            2740                2745                2750        
Ser Ile Tyr Gln Ala Met Trp Lys Gly Val Leu Arg Pro Gly Thr Ala
        2755                2760                2765            
Leu Val Leu Leu Glu Ala Gln Ala Ala Thr Gly Phe Val Ile Asp Pro
    2770                2775                2780                
Val Arg Asn Leu Arg Leu Ser Val Glu Glu Ala Val Ala Ala Gly Val
2785                2790                2795                2800
Val Gly Gly Glu Ile Gln Glu Lys Leu Leu Ser Ala Glu Arg Ala Val
                2805                2810                2815    
Thr Gly Tyr Thr Asp Pro Tyr Thr Gly Gln Gln Ile Ser Leu Phe Gln
            2820                2825                2830        
Ala Met Gln Lys Asp Leu Ile Val Arg Glu His Gly Ile Arg Leu Leu
        2835                2840                2845            
Glu Ala Gln Ile Ala Thr Gly Gly Val Ile Asp Pro Val His Ser His
    2850                2855                2860                
Arg Val Pro Val Asp Val Ala Tyr Arg Arg Gly Tyr Phe Asp Glu Glu
2865                2870                2875                2880
Met Asn Arg Val Leu Ala Asp Pro Ser Asp Asp Thr Lys Gly Phe Phe
                2885                2890                2895    
Asp Pro Asn Thr His Glu Asn Leu Thr Tyr Val Gln Leu Leu Arg Arg
            2900                2905                2910        
Cys Val Pro Asp Pro Asp Thr Gly Leu Tyr Met Leu Gln Leu Ala Gly
        2915                2920                2925            
Arg Gly Ser Ala Val His Gln Leu Ser Glu Glu Leu Arg Cys Ala Leu
    2930                2935                2940                
Arg Asp Ala Arg Val Thr Pro Gly Ser Gly Ala Leu Gln Gly Gln Ser
2945                2950                2955                2960
Val Ser Val Trp Glu Leu Leu Phe Tyr Arg Glu Val Ser Glu Asp Arg
                2965                2970                2975    
Arg Gln Asp Leu Leu Ser Arg Tyr Arg Ala Gly Thr Leu Thr Val Glu
            2980                2985                2990        
Glu Leu Gly Ala Thr Leu Thr Ser Leu Leu Ala Gln Ala Gln Ala Gln
        2995                3000                3005            
Ala Arg Ala Glu Ala Glu Ala Gly Ser Pro Arg Pro Asp Pro Arg Glu
    3010                3015                3020                
Ala Leu Arg Ala Ala Thr Met Glu Val Lys Val Gly Arg Leu Arg Gly
3025                3030                3035                3040
Arg Ala Val Pro Val Trp Asp Val Leu Ala Ser Gly Tyr Val Ser Gly
                3045                3050                3055    
Ala Ala Arg Glu Glu Leu Leu Ala Glu Phe Gly Ser Gly Thr Leu Asp
            3060                3065                3070        
Leu Pro Ala Leu Thr Arg Arg Leu Thr Ala Ile Ile Glu Glu Ala Glu
        3075                3080                3085            
Glu Ala Pro Gly Ala Arg Pro Gln Leu Gln Asp Ala Trp Arg Gly Pro
    3090                3095                3100                
Arg Glu Pro Gly Pro Ala Gly Arg Gly Asp Gly Asp Ser Gly Arg Ser
3105                3110                3115                3120
Gln Arg Glu Gly Gln Gly Glu Gly Glu Thr Gln Glu Ala Ala Ala Ala
                3125                3130                3135    
Ala Ala Ala Ala Arg Arg Gln Glu Gln Thr Leu Arg Asp Ala Thr Met
            3140                3145                3150        
Glu Val Gln Arg Gly Gln Phe Gln Gly Arg Pro Val Ser Val Trp Asp
        3155                3160                3165            
Val Leu Phe Ser Ser Tyr Leu Ser Glu Ala Arg Arg Asp Glu Leu Leu
    3170                3175                3180                
Ala Gln His Ala Ala Gly Ala Leu Gly Leu Pro Asp Leu Val Ala Val
3185                3190                3195                3200
Leu Thr Arg Val Ile Glu Glu Thr Glu Glu Arg Leu Ser Lys Val Ser
                3205                3210                3215    
Phe Arg Gly Leu Arg Arg Gln Val Ser Ala Ser Glu Leu His Thr Ser
            3220                3225                3230        
Gly Ile Leu Gly Pro Glu Thr Leu Arg Asp Leu Ala Gln Gly Thr Lys
        3235                3240                3245            
Thr Leu Gln Glu Val Thr Glu Met Asp Ser Val Lys Arg Tyr Leu Glu
    3250                3255                3260                
Gly Thr Ser Cys Ile Ala Gly Val Leu Val Pro Ala Lys Asp Gln Pro
3265                3270                3275                3280
Gly Arg Gln Glu Lys Met Ser Ile Tyr Gln Ala Met Trp Lys Gly Val
                3285                3290                3295    
Leu Arg Pro Gly Thr Ala Leu Val Leu Leu Glu Ala Gln Ala Ala Thr
            3300                3305                3310        
Gly Phe Val Ile Asp Pro Val Arg Asn Leu Arg Leu Ser Val Glu Glu
        3315                3320                3325            
Ala Val Ala Ala Gly Val Val Gly Gly Glu Ile Gln Glu Lys Leu Leu
    3330                3335                3340                
Ser Ala Glu Arg Ala Val Thr Gly Tyr Thr Asp Pro Tyr Thr Gly Gln
3345                3350                3355                3360
Gln Ile Ser Leu Phe Gln Ala Met Gln Lys Asp Leu Ile Val Arg Glu
                3365                3370                3375    
His Gly Ile Arg Leu Leu Glu Ala Gln Ile Ala Thr Gly Gly Val Ile
            3380                3385                3390        
Asp Pro Val His Ser His Arg Val Pro Val Asp Val Ala Tyr Arg Arg
        3395                3400                3405            
Gly Tyr Phe Asp Glu Glu Met Asn Arg Val Leu Ala Asp Pro Ser Asp
    3410                3415                3420                
Asp Thr Lys Gly Phe Phe Asp Pro Asn Thr His Glu Asn Leu Thr Tyr
3425                3430                3435                3440
Val Gln Leu Leu Arg Arg Cys Val Pro Asp Pro Asp Thr Gly Leu Tyr
                3445                3450                3455    
Met Leu Gln Leu Ala Gly Arg Gly Ser Ala Val His Gln Leu Ser Glu
            3460                3465                3470        
Glu Leu Arg Cys Ala Leu Arg Asp Ala Arg Val Thr Pro Gly Ser Gly
        3475                3480                3485            
Ala Leu Gln Gly Gln Ser Val Ser Val Trp Glu Leu Leu Phe Tyr Arg
    3490                3495                3500                
Glu Val Ser Glu Asp Arg Arg Gln Asp Leu Leu Ser Arg Tyr Arg Ala
3505                3510                3515                3520
Gly Thr Leu Thr Val Glu Glu Leu Gly Ala Thr Leu Thr Ser Leu Leu
                3525                3530                3535    
Ala Gln Ala Gln Ala Gln Ala Arg Ala Glu Ala Glu Ala Gly Ser Pro
            3540                3545                3550        
Arg Pro Asp Pro Arg Glu Ala Leu Arg Ala Ala Thr Met Glu Val Lys
        3555                3560                3565            
Val Gly Arg Leu Arg Gly Arg Ala Val Pro Val Trp Asp Val Leu Ala
    3570                3575                3580                
Ser Gly Tyr Val Ser Gly Ala Ala Arg Glu Glu Leu Leu Ala Glu Phe
3585                3590                3595                3600
Gly Ser Gly Thr Leu Asp Leu Pro Ala Leu Thr Arg Arg Leu Thr Ala
                3605                3610                3615    
Ile Ile Glu Glu Ala Glu Glu Ala Pro Gly Ala Arg Pro Gln Leu Gln
            3620                3625                3630        
Asp Ala Trp Arg Gly Pro Arg Glu Pro Gly Pro Ala Gly Arg Gly Asp
        3635                3640                3645            
Gly Asp Ser Gly Arg Ser Gln Arg Glu Gly Gln Gly Glu Gly Glu Thr
    3650                3655                3660                
Gln Glu Ala Ala Ala Ala Ala Ala Ala Ala Arg Arg Gln Glu Gln Thr
3665                3670                3675                3680
Leu Arg Asp Ala Thr Met Glu Val Gln Arg Gly Gln Phe Gln Gly Arg
                3685                3690                3695    
Pro Val Ser Val Trp Asp Val Leu Phe Ser Ser Tyr Leu Ser Glu Ala
            3700                3705                3710        
Arg Arg Asp Glu Leu Leu Ala Gln His Ala Ala Gly Ala Leu Gly Leu
        3715                3720                3725            
Pro Asp Leu Val Ala Val Leu Thr Arg Val Ile Glu Glu Thr Glu Glu
    3730                3735                3740                
Arg Leu Ser Lys Val Ser Phe Arg Gly Leu Arg Arg Gln Val Ser Ala
3745                3750                3755                3760
Ser Glu Leu His Thr Ser Gly Ile Leu Gly Pro Glu Thr Leu Arg Asp
                3765                3770                3775    
Leu Ala Gln Gly Thr Lys Thr Leu Gln Glu Val Thr Glu Met Asp Ser
            3780                3785                3790        
Val Lys Arg Tyr Leu Glu Gly Thr Ser Cys Ile Ala Gly Val Leu Val
        3795                3800                3805            
Pro Ala Lys Asp Gln Pro Gly Arg Gln Glu Lys Met Ser Ile Tyr Gln
    3810                3815                3820                
Ala Met Trp Lys Gly Val Leu Arg Pro Gly Thr Ala Leu Val Leu Leu
3825                3830                3835                3840
Glu Ala Gln Ala Ala Thr Gly Phe Val Ile Asp Pro Val Arg Asn Leu
                3845                3850                3855    
Arg Leu Ser Val Glu Glu Ala Val Ala Ala Gly Val Val Gly Gly Glu
            3860                3865                3870        
Ile Gln Glu Lys Leu Leu Ser Ala Glu Arg Ala Val Thr Gly Tyr Thr
        3875                3880                3885            
Asp Pro Tyr Thr Gly Gln Gln Ile Ser Leu Phe Gln Ala Met Gln Lys
    3890                3895                3900                
Asp Leu Ile Val Arg Glu His Gly Ile Arg Leu Leu Glu Ala Gln Ile
3905                3910                3915                3920
Ala Thr Gly Gly Val Ile Asp Pro Val His Ser His Arg Val Pro Val
                3925                3930                3935    
Asp Val Ala Tyr Arg Arg Gly Tyr Phe Asp Glu Glu Met Asn Arg Val
            3940                3945                3950        
Leu Ala Asp Pro Ser Asp Asp Thr Lys Gly Phe Phe Asp Pro Asn Thr
        3955                3960                3965            
His Glu Asn Leu Thr Tyr Val Gln Leu Leu Arg Arg Cys Val Pro Asp
    3970                3975                3980                
Pro Asp Thr Gly Leu Tyr Met Leu Gln Leu Ala Gly Arg Gly Ser Ala
3985                3990                3995                4000
Val His Gln Leu Ser Glu Glu Leu Arg Cys Ala Leu Arg Asp Ala Arg
                4005                4010                4015    
Val Thr Pro Gly Ser Gly Ala Leu Gln Gly Gln Ser Val Ser Val Trp
            4020                4025                4030        
Glu Leu Leu Phe Tyr Arg Glu Val Ser Glu Asp Arg Arg Gln Asp Leu
        4035                4040                4045            
Leu Ser Arg Tyr Arg Ala Ser Thr Leu Thr Val Glu Glu Leu Gly Ala
    4050                4055                4060                
Thr Leu Thr Ser Leu Leu Ala Gln Ala Gln Ala Gln Ala Arg Ala Glu
4065                4070                4075                4080
Ala Glu Ala Gly Ser Pro Arg Pro Asp Pro Arg Glu Ala Leu Arg Ala
                4085                4090                4095    
Ala Thr Met Glu Val Lys Val Gly Arg Leu Arg Gly Arg Ala Val Pro
            4100                4105                4110        
Val Trp Asp Val Leu Ala Ser Gly Tyr Val Ser Arg Ala Ala Arg Glu
        4115                4120                4125            
Glu Leu Leu Ala Glu Phe Gly Ser Gly Thr Leu Asp Leu Pro Ala Leu
    4130                4135                4140                
Thr Arg Arg Leu Thr Ala Ile Ile Glu Glu Ala Glu Glu Ala Pro Gly
4145                4150                4155                4160
Ala Arg Pro Gln Leu Gln Asp Ala Trp Arg Gly Pro Arg Glu Pro Gly
                4165                4170                4175    
Pro Ala Gly Arg Gly Asp Gly Asp Ser Gly Arg Ser Gln Arg Glu Gly
            4180                4185                4190        
Gln Gly Glu Gly Glu Thr Gln Glu Ala Ala Ala Ala Thr Ala Ala Ala
        4195                4200                4205            
Arg Arg Gln Glu Gln Thr Leu Arg Asp Ala Thr Met Glu Val Gln Arg
    4210                4215                4220                
Gly Gln Phe Gln Gly Arg Pro Val Ser Val Trp Asp Val Leu Phe Ser
4225                4230                4235                4240
Ser Tyr Leu Ser Glu Ala Arg Arg Asp Glu Leu Leu Ala Gln His Ala
                4245                4250                4255    
Ala Gly Ala Leu Gly Leu Pro Asp Leu Val Ala Val Leu Thr Arg Val
            4260                4265                4270        
Ile Glu Glu Thr Glu Glu Arg Leu Ser Lys Val Ser Phe Arg Gly Leu
        4275                4280                4285            
Arg Arg Gln Val Ser Ala Ser Glu Leu His Thr Ser Gly Ile Leu Gly
    4290                4295                4300                
Pro Glu Thr Leu Arg Asp Leu Ala Gln Gly Thr Lys Thr Leu Gln Glu
4305                4310                4315                4320
Val Thr Glu Met Asp Ser Val Lys Arg Tyr Leu Glu Gly Thr Ser Cys
                4325                4330                4335    
Ile Ala Gly Val Leu Val Pro Ala Lys Asp Gln Pro Gly Arg Gln Glu
            4340                4345                4350        
Lys Met Ser Ile Tyr Gln Ala Met Trp Lys Gly Val Leu Arg Pro Gly
        4355                4360                4365            
Thr Ala Leu Val Leu Leu Glu Ala Gln Ala Ala Thr Gly Phe Val Ile
    4370                4375                4380                
Asp Pro Val Arg Asn Leu Arg Leu Ser Val Glu Glu Ala Val Ala Ala
4385                4390                4395                4400
Gly Val Val Gly Gly Glu Ile Gln Glu Lys Leu Leu Ser Ala Glu Arg
                4405                4410                4415    
Ala Val Thr Gly Tyr Thr Asp Pro Tyr Thr Gly Gln Gln Ile Ser Leu
            4420                4425                4430        
Phe Gln Ala Met Gln Lys Asp Leu Ile Val Arg Glu His Gly Ile Arg
        4435                4440                4445            
Leu Leu Glu Ala Gln Ile Ala Thr Gly Gly Val Ile Asp Pro Val His
    4450                4455                4460                
Ser His Arg Val Pro Val Asp Val Ala Tyr Arg Arg Gly Tyr Phe Asp
4465                4470                4475                4480
Glu Glu Met Asn Arg Val Leu Ala Asp Pro Ser Asp Asp Thr Lys Gly
                4485                4490                4495    
Phe Phe Asp Pro Asn Thr His Glu Asn Leu Thr Tyr Val Gln Leu Leu
            4500                4505                4510        
Arg Arg Cys Val Pro Asp Pro Asp Thr Gly Leu Tyr Met Leu Gln Leu
        4515                4520                4525            
Ala Gly Arg Gly Ser Ala Val His Gln Leu Ser Glu Glu Leu Arg Cys
    4530                4535                4540                
Ala Leu Arg Asp Ala Arg Val Thr Pro Gly Ser Gly Ala Leu Gln Gly
4545                4550                4555                4560
Gln Ser Val Ser Val Trp Glu Leu Leu Phe Tyr Arg Glu Val Ser Glu
                4565                4570                4575    
Asp Arg Arg Gln Asp Leu Leu Ser Arg Tyr Arg Ala Gly Thr Leu Thr
            4580                4585                4590        
Val Glu Glu Leu Gly Ala Thr Leu Thr Ser Leu Leu Ala Gln Ala Gln
        4595                4600                4605            
Ala Gln Ala Arg Ala Glu Ala Glu Ala Gly Ser Pro Arg Pro Asp Pro
    4610                4615                4620                
Arg Glu Ala Leu Arg Ala Ala Thr Met Glu Val Lys Val Gly Arg Leu
4625                4630                4635                4640
Arg Gly Arg Ala Val Pro Val Trp Asp Val Leu Ala Ser Gly Tyr Val
                4645                4650                4655    
Ser Gly Ala Ala Arg Glu Glu Leu Leu Ala Glu Phe Gly Ser Gly Thr
            4660                4665                4670        
Leu Asp Leu Pro Ala Leu Thr Arg Arg Leu Thr Ala Ile Ile Glu Glu
        4675                4680                4685            
Ala Glu Glu Ala Pro Gly Ala Arg Pro Gln Leu Gln Asp Ala Trp Arg
    4690                4695                4700                
Gly Pro Arg Glu Pro Gly Pro Ala Gly Arg Gly Asp Gly Asp Ser Gly
4705                4710                4715                4720
Arg Ser Gln Arg Glu Gly Gln Gly Glu Gly Glu Thr Gln Glu Ala Ala
                4725                4730                4735    
Ala Ala Ala Ala Ala Ala Arg Arg Gln Glu Gln Thr Leu Arg Asp Ala
            4740                4745                4750        
Thr Met Glu Val Gln Arg Gly Gln Phe Gln Gly Arg Pro Val Ser Val
        4755                4760                4765            
Trp Asp Val Leu Phe Ser Ser Tyr Leu Ser Glu Ala Arg Arg Asp Glu
    4770                4775                4780                
Leu Leu Ala Gln His Ala Ala Gly Ala Leu Gly Leu Pro Asp Leu Val
4785                4790                4795                4800
Ala Val Leu Thr Arg Val Ile Glu Glu Thr Glu Glu Arg Leu Ser Lys
                4805                4810                4815    
Val Ser Phe Arg Gly Leu Arg Arg Gln Val Ser Ala Ser Glu Leu His
            4820                4825                4830        
Thr Ser Gly Ile Leu Gly Pro Glu Thr Leu Arg Asp Leu Ala Gln Gly
        4835                4840                4845            
Thr Lys Thr Leu Gln Glu Val Thr Glu Met Asp Ser Val Lys Arg Tyr
    4850                4855                4860                
Leu Glu Gly Thr Ser Cys Ile Ala Gly Val Leu Val Pro Ala Lys Asp
4865                4870                4875                4880
Gln Pro Gly Arg Gln Glu Lys Met Ser Ile Tyr Gln Ala Met Trp Lys
                4885                4890                4895    
Gly Val Leu Arg Pro Gly Thr Ala Leu Val Leu Leu Glu Ala Gln Ala
            4900                4905                4910        
Ala Thr Gly Phe Val Ile Asp Pro Val Arg Asn Leu Arg Leu Ser Val
        4915                4920                4925            
Glu Glu Ala Val Ala Ala Gly Val Val Gly Gly Glu Ile Gln Glu Lys
    4930                4935                4940                
Leu Leu Ser Ala Glu Arg Ala Val Thr Gly Tyr Thr Asp Pro Tyr Thr
4945                4950                4955                4960
Gly Gln Gln Ile Ser Leu Phe Gln Ala Met Gln Lys Asp Leu Ile Val
                4965                4970                4975    
Arg Glu His Gly Ile Arg Leu Leu Glu Ala Gln Ile Ala Thr Gly Gly
            4980                4985                4990        
Val Ile Asp Pro Val His Ser His Arg Val Pro Val Asp Val Ala Tyr
        4995                5000                5005            
Arg Arg Gly Tyr Phe Asp Glu Glu Met Asn Arg Val Leu Ala Asp Pro
    5010                5015                5020                
Ser Asp Asp Thr Lys Gly Phe Phe Asp Pro Asn Thr His Glu Asn Leu
5025                5030                5035                5040
Thr Tyr Leu Gln Leu Leu Gln Arg Ala Thr Leu Asp Pro Glu Thr Gly
                5045                5050                5055    
Leu Leu Phe Leu Ser Leu Ser Leu Gln
            5060                5065


<210> 1744
<211> 267
<212> PRT
<213> Homo sapiens

<400> 1744
Met Ala Ala Pro Val Val Thr Ala Pro Gly Arg Ala Leu Leu Arg Ala
 1               5                  10                  15      
Gly Ala Gly Arg Leu Leu Arg Gly Gly Val Gln Glu Leu Leu Arg Pro
            20                  25                  30          
Arg His Glu Gly Asn Ala Pro Asp Leu Ala Cys Asn Phe Ser Leu Ser
        35                  40                  45              
Gln Asn Arg Gly Thr Val Ile Val Glu Arg Trp Trp Lys Val Pro Leu
    50                  55                  60                  
Ala Gly Glu Gly Arg Lys Pro Arg Leu His Arg Arg His Arg Val Tyr
65                  70                  75                  80  
Lys Leu Val Glu Asp Thr Lys His Arg Pro Lys Glu Asn Leu Glu Leu
                85                  90                  95      
Ile Leu Thr Gln Ser Val Glu Asn Val Gly Val Arg Gly Asp Leu Val
            100                 105                 110         
Ser Val Lys Lys Ser Leu Gly Arg Asn Arg Leu Leu Pro Gln Gly Leu
        115                 120                 125             
Ala Val Tyr Ala Ser Pro Glu Asn Lys Lys Leu Phe Glu Glu Glu Lys
    130                 135                 140                 
Leu Leu Arg Gln Glu Gly Lys Leu Glu Lys Ile Gln Thr Lys Ala Gly
145                 150                 155                 160 
Glu Ala Thr Val Lys Phe Leu Lys Ser Cys Arg Leu Glu Val Gly Met
                165                 170                 175     
Lys Asn Asn Val Lys Trp Glu Leu Asn Pro Glu Ile Val Ala Arg His
            180                 185                 190         
Phe Phe Lys Asn Leu Gly Val Val Val Ala Pro His Thr Leu Lys Leu
        195                 200                 205             
Pro Glu Glu Pro Ile Thr Arg Trp Gly Glu Tyr Trp Cys Glu Val Thr
    210                 215                 220                 
Val Asn Gly Leu Asp Thr Val Arg Val Pro Met Ser Val Val Asn Phe
225                 230                 235                 240 
Glu Lys Pro Lys Thr Lys Arg Tyr Lys Tyr Trp Leu Ala Gln Gln Ala
                245                 250                 255     
Ala Lys Ala Met Ala Pro Thr Ser Pro Gln Ile
            260                 265         


<210> 1745
<211> 444
<212> PRT
<213> Homo sapiens

<400> 1745
Met Glu Glu Glu Gly Lys Lys Gly Lys Lys Pro Gly Ile Val Ser Pro
 1               5                  10                  15      
Phe Lys Arg Val Phe Leu Lys Gly Glu Lys Ser Arg Asp Lys Lys Ala
            20                  25                  30          
His Glu Lys Val Thr Glu Arg Arg Pro Leu His Thr Val Val Leu Ser
        35                  40                  45              
Leu Pro Glu Arg Val Glu Pro Asp Arg Leu Leu Ser Asp Tyr Ile Glu
    50                  55                  60                  
Lys Glu Val Lys Tyr Leu Gly Gln Leu Thr Ser Ile Pro Gly Tyr Leu
65                  70                  75                  80  
Asn Pro Ser Ser Arg Thr Glu Ile Leu His Phe Ile Asp Asn Ala Lys
                85                  90                  95      
Arg Ala His Gln Leu Pro Gly His Leu Thr Gln Glu His Asp Ala Val
            100                 105                 110         
Leu Ser Leu Ser Ala Tyr Asn Val Lys Leu Ala Trp Arg Asp Gly Glu
        115                 120                 125             
Asp Ile Ile Leu Arg Val Pro Ile His Asp Ile Ala Ala Val Ser Tyr
    130                 135                 140                 
Val Arg Asp Asp Ala Ala His Leu Val Val Leu Lys Thr Ala Gln Asp
145                 150                 155                 160 
Pro Gly Ile Ser Pro Ser Gln Ser Leu Cys Ala Glu Ser Ser Arg Gly
                165                 170                 175     
Leu Ser Ala Gly Ser Leu Ser Glu Ser Ala Val Gly Pro Val Glu Ala
            180                 185                 190         
Cys Cys Leu Val Ile Leu Ala Ala Glu Ser Lys Val Ala Ala Glu Glu
        195                 200                 205             
Leu Cys Cys Leu Leu Gly Gln Val Phe Gln Val Val Tyr Thr Glu Ser
    210                 215                 220                 
Thr Ile Asp Phe Leu Asp Arg Ala Ile Phe Asp Gly Ala Ser Thr Pro
225                 230                 235                 240 
Thr His His Leu Ser Leu His Ser Asp Asp Ser Ser Thr Lys Val Asp
                245                 250                 255     
Ile Lys Glu Thr Tyr Glu Val Glu Ala Ser Thr Phe Cys Phe Pro Glu
            260                 265                 270         
Ser Val Asp Val Gly Gly Ala Ser Pro His Ser Lys Thr Ile Ser Glu
        275                 280                 285             
Ser Glu Leu Ser Ala Ser Ala Thr Glu Leu Leu Gln Asp Tyr Met Leu
    290                 295                 300                 
Thr Leu Arg Thr Lys Leu Ser Ser Gln Glu Ile Gln Gln Phe Ala Ala
305                 310                 315                 320 
Leu Leu His Glu Tyr Arg Asn Gly Ala Ser Ile His Glu Phe Cys Ile
                325                 330                 335     
Asn Leu Arg Gln Leu Tyr Gly Asp Ser Arg Lys Phe Leu Leu Leu Gly
            340                 345                 350         
Leu Arg Pro Phe Ile Pro Glu Lys Asp Ser Gln His Phe Glu Asn Phe
        355                 360                 365             
Leu Glu Thr Ile Gly Val Lys Asp Gly Arg Gly Ile Ile Thr Asp Ser
    370                 375                 380                 
Phe Gly Arg His Arg Arg Ala Leu Ser Thr Thr Ser Ser Ser Thr Thr
385                 390                 395                 400 
Asn Gly Asn Arg Ala Thr Gly Ser Ser Asp Asp Arg Ser Ala Pro Ser
                405                 410                 415     
Glu Gly Asp Glu Trp Asp Arg Met Ile Ser Asp Ile Ser Ser Asp Ile
            420                 425                 430         
Glu Ala Leu Gly Cys Ser Met Asp Gln Asp Ser Ala
        435                 440                 


<210> 1746
<211> 802
<212> PRT
<213> Homo sapiens

<400> 1746
Met Gly Tyr Leu Arg Ile Phe Ser Pro His Pro Ala Lys Thr Gly Asp
 1               5                  10                  15      
Gly Ala Gln Ala Glu Asp Leu Leu Leu Glu Val Asp Leu Arg Asp Pro
            20                  25                  30          
Val Leu Gln Val Glu Val Gly Lys Phe Val Ser Gly Thr Glu Met Leu
        35                  40                  45              
His Leu Ala Val Leu His Ser Arg Lys Leu Cys Val Tyr Ser Val Ser
    50                  55                  60                  
Gly Thr Leu Gly Asn Val Glu His Gly Asn Gln Cys Gln Met Lys Leu
65                  70                  75                  80  
Met Tyr Glu His Asn Leu Gln Arg Thr Ala Cys Asn Met Thr Tyr Gly
                85                  90                  95      
Ser Phe Gly Gly Val Lys Gly Arg Asp Leu Ile Cys Ile Gln Ser Met
            100                 105                 110         
Asp Gly Met Leu Met Val Phe Glu Gln Glu Ser Tyr Ala Phe Gly Arg
        115                 120                 125             
Phe Leu Pro Gly Phe Leu Leu Pro Gly Pro Leu Ala Tyr Ser Ser Arg
    130                 135                 140                 
Thr Asp Ser Phe Leu Thr Val Ser Ser Cys Gln Gln Val Glu Ser Tyr
145                 150                 155                 160 
Lys Tyr Gln Val Leu Ala Phe Ala Thr Asp Ala Asp Lys Arg Gln Glu
                165                 170                 175     
Thr Glu Gln Gln Lys Leu Gly Ser Gly Lys Arg Leu Val Val Asp Trp
            180                 185                 190         
Thr Leu Asn Ile Gly Glu Gln Ala Leu Asp Ile Cys Ile Val Ser Phe
        195                 200                 205             
Asn Gln Ser Ala Ser Ser Val Phe Val Leu Gly Glu Arg Asn Phe Phe
    210                 215                 220                 
Cys Leu Lys Asp Asn Gly Gln Ile Arg Phe Met Lys Arg Leu Asp Trp
225                 230                 235                 240 
Ser Pro Ser Cys Phe Leu Pro Tyr Cys Ser Val Ser Glu Gly Thr Ile
                245                 250                 255     
Asn Thr Leu Ile Gly Asn His Asn Asn Met Leu His Ile Tyr Gln Asp
            260                 265                 270         
Val Thr Leu Lys Trp Ala Thr Gln Leu Pro His Ile Pro Val Ala Val
        275                 280                 285             
Arg Val Gly Cys Leu His Asp Leu Lys Gly Val Ile Val Thr Leu Ser
    290                 295                 300                 
Asp Asp Gly His Leu Gln Cys Ser Tyr Leu Gly Thr Asp Pro Ser Leu
305                 310                 315                 320 
Phe Gln Ala Pro Asn Val Gln Ser Arg Glu Leu Asn Tyr Asp Glu Leu
                325                 330                 335     
Asp Val Glu Met Lys Glu Leu Gln Lys Ile Ile Lys Asp Val Asn Lys
            340                 345                 350         
Ser Gln Gly Val Trp Pro Met Thr Glu Arg Glu Asp Asp Leu Asn Val
        355                 360                 365             
Ser Val Val Val Ser Pro Asn Phe Asp Ser Val Ser Gln Ala Thr Asp
    370                 375                 380                 
Val Glu Val Gly Thr Asp Leu Val Pro Ser Val Thr Val Lys Val Thr
385                 390                 395                 400 
Leu Gln Asn Arg Val Ile Leu Gln Lys Ala Lys Leu Ser Val Tyr Val
                405                 410                 415     
Gln Pro Pro Leu Glu Leu Thr Cys Asp Gln Phe Thr Phe Glu Phe Met
            420                 425                 430         
Ser Ile Pro Arg Val Ile Gln Cys Lys Phe Arg Leu Pro Leu Lys Leu
        435                 440                 445             
Ile Cys Leu Pro Gly Gln Pro Ser Lys Thr Ala Ser His Lys Ile Thr
    450                 455                 460                 
Ile Asp Thr Asn Lys Ser Pro Val Ser Leu Leu Ser Leu Phe Pro Gly
465                 470                 475                 480 
Phe Ala Ser Gln Ser Asp Asp Asp Gln Val Asn Val Met Gly Phe His
                485                 490                 495     
Phe Leu Gly Gly Ala Arg Ile Thr Val Leu Ala Ser Lys Thr Ser Gln
            500                 505                 510         
Arg Tyr Arg Ile Gln Ser Glu Gln Phe Glu Asp Leu Trp Leu Ile Thr
        515                 520                 525             
Asn Glu Leu Ile Leu Arg Leu Gln Glu Tyr Phe Glu Lys Gln Gly Val
    530                 535                 540                 
Lys Asp Phe Ala Cys Ser Phe Ser Gly Ser Ile Pro Leu Gln Glu Tyr
545                 550                 555                 560 
Phe Glu Leu Ile Asp His His Phe Glu Leu Arg Ile Asn Gly Glu Lys
                565                 570                 575     
Leu Glu Glu Leu Leu Ser Glu Arg Ala Val Gln Phe Arg Ala Ile Gln
            580                 585                 590         
Arg Arg Leu Leu Ala Arg Phe Lys Asp Lys Thr Pro Ala Pro Leu Gln
        595                 600                 605             
His Leu Asp Thr Leu Leu Asp Gly Thr Tyr Lys Gln Val Ile Ala Leu
    610                 615                 620                 
Ala Asp Ala Val Glu Glu Asn Gln Gly Asn Leu Phe Gln Ser Phe Thr
625                 630                 635                 640 
Arg Leu Lys Ser Ala Thr His Leu Val Ile Leu Leu Ile Ala Leu Trp
                645                 650                 655     
Gln Lys Leu Ser Ala Asp Gln Val Ala Ile Leu Glu Ala Ala Phe Leu
            660                 665                 670         
Pro Leu Gln Glu Asp Thr Gln Glu Leu Gly Trp Glu Glu Thr Val Asp
        675                 680                 685             
Ala Ala Ile Ser His Leu Leu Lys Thr Cys Leu Ser Lys Ser Ser Lys
    690                 695                 700                 
Glu Gln Ala Leu Asn Leu Asn Ser Gln Leu Asn Ile Pro Lys Asp Thr
705                 710                 715                 720 
Ser Gln Leu Lys Lys His Ile Thr Leu Leu Cys Asp Arg Leu Ser Lys
                725                 730                 735     
Gly Gly Arg Leu Cys Leu Ser Thr Asp Ala Ala Ala Pro Gln Thr Met
            740                 745                 750         
Val Met Pro Gly Gly Cys Thr Thr Ile Pro Glu Ser Asp Leu Glu Glu
        755                 760                 765             
Arg Ser Val Glu Gln Asp Ser Thr Glu Leu Phe Thr Asn His Arg His
    770                 775                 780                 
Leu Thr Ala Glu Thr Pro Arg Pro Glu Val Ser Pro Leu Gln Gly Val
785                 790                 795                 800 
Ser Glu
        


<210> 1747
<211> 384
<212> PRT
<213> Homo sapiens

<400> 1747
Met Ala Ala Thr Ala Ser Pro Gln Pro Leu Ala Thr Glu Asp Ala Asp
 1               5                  10                  15      
Ser Glu Asn Ser Ser Phe Tyr Tyr Tyr Asp Tyr Leu Asp Glu Val Ala
            20                  25                  30          
Phe Met Leu Cys Arg Lys Asp Ala Val Val Ser Phe Gly Lys Val Phe
        35                  40                  45              
Leu Pro Val Phe Tyr Ser Leu Ile Phe Val Leu Gly Leu Ser Gly Asn
    50                  55                  60                  
Leu Leu Leu Leu Met Val Leu Leu Arg Tyr Val Pro Arg Arg Arg Met
65                  70                  75                  80  
Val Glu Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asn Leu Leu Phe Leu
                85                  90                  95      
Val Thr Leu Pro Phe Trp Gly Ile Ser Val Ala Trp His Trp Val Phe
            100                 105                 110         
Gly Ser Phe Leu Cys Lys Met Val Ser Thr Leu Tyr Thr Ile Asn Phe
        115                 120                 125             
Tyr Ser Gly Ile Phe Phe Ile Ser Cys Met Ser Leu Asp Lys Tyr Leu
    130                 135                 140                 
Glu Ile Val His Ala Gln Pro Tyr His Arg Leu Arg Thr Arg Ala Lys
145                 150                 155                 160 
Ser Leu Leu Leu Ala Thr Ile Val Trp Ala Val Ser Leu Ala Val Ser
                165                 170                 175     
Ile Pro Asp Met Val Phe Val Gln Thr His Glu Asn Pro Lys Gly Val
            180                 185                 190         
Trp Asn Cys His Ala Asp Phe Gly Gly His Gly Thr Ile Trp Lys Leu
        195                 200                 205             
Phe Leu Arg Phe Gln Gln Asn Leu Leu Gly Phe Leu Leu Pro Leu Leu
    210                 215                 220                 
Ala Met Ile Phe Phe Tyr Ser Arg Ile Gly Cys Val Leu Val Arg Leu
225                 230                 235                 240 
Arg Pro Ala Gly Gln Gly Arg Ala Leu Lys Ile Ala Ala Ala Leu Val
                245                 250                 255     
Val Ala Phe Phe Val Leu Trp Phe Pro Tyr Asn Leu Thr Leu Phe Leu
            260                 265                 270         
His Thr Leu Leu Asp Leu Gln Val Phe Gly Asn Cys Glu Val Ser Gln
        275                 280                 285             
His Leu Asp Tyr Ala Leu Gln Val Thr Glu Ser Ile Ala Phe Leu His
    290                 295                 300                 
Cys Cys Phe Ser Pro Ile Leu Tyr Ala Phe Ser Ser His Arg Phe Arg
305                 310                 315                 320 
Gln Tyr Leu Lys Ala Phe Leu Ala Ala Val Leu Gly Trp His Leu Ala
                325                 330                 335     
Pro Gly Thr Ala Gln Ala Ser Leu Ser Ser Cys Ser Glu Ser Ser Ile
            340                 345                 350         
Leu Thr Ala Gln Glu Glu Met Thr Gly Met Asn Asp Leu Gly Glu Arg
        355                 360                 365             
Gln Ser Glu Asn Tyr Pro Asn Lys Glu Asp Val Gly Asn Lys Ser Ala
    370                 375                 380                 


<210> 1748
<211> 295
<212> PRT
<213> Homo sapiens

<400> 1748
Met Pro Val His Thr Leu Ser Pro Gly Ala Pro Ser Ala Pro Ala Leu
 1               5                  10                  15      
Pro Cys Arg Leu Arg Thr Arg Val Pro Gly Tyr Leu Leu Arg Gly Pro
            20                  25                  30          
Ala Asp Gly Gly Ala Arg Lys Pro Ser Ala Val Glu Arg Leu Glu Ala
        35                  40                  45              
Asp Lys Ala Lys Tyr Val Lys Ser Leu His Val Ala Asn Thr Arg Gln
    50                  55                  60                  
Glu Pro Val Gln Pro Leu Leu Ser Lys Gln Pro Leu Phe Ser Pro Glu
65                  70                  75                  80  
Thr Arg Arg Thr Val Leu Thr Pro Ser Arg Arg Ala Leu Pro Gly Pro
                85                  90                  95      
Cys Arg Arg Pro Gln Leu Asp Leu Asp Ile Leu Ser Ser Leu Ile Asp
            100                 105                 110         
Leu Cys Asp Ser Pro Val Ser Pro Ala Glu Ala Ser Arg Thr Pro Gly
        115                 120                 125             
Arg Ala Glu Gly Ala Gly Arg Pro Pro Pro Ala Thr Pro Pro Arg Pro
    130                 135                 140                 
Pro Pro Ser Thr Ser Ala Val Arg Arg Val Asp Val Arg Pro Leu Pro
145                 150                 155                 160 
Ala Ser Pro Ala Arg Pro Cys Pro Ser Pro Gly Pro Ala Ala Ala Ser
                165                 170                 175     
Ser Pro Ala Arg Pro Pro Gly Leu Gln Arg Ser Lys Ser Asp Leu Ser
            180                 185                 190         
Glu Arg Phe Ser Arg Ala Ala Ala Asp Leu Glu Arg Phe Phe Asn Phe
        195                 200                 205             
Cys Gly Leu Asp Pro Glu Glu Ala Arg Gly Leu Gly Val Ala His Leu
    210                 215                 220                 
Ala Arg Ala Ser Ser Asp Ile Val Ser Leu Ala Gly Pro Ser Ala Gly
225                 230                 235                 240 
Pro Gly Ser Ser Glu Gly Gly Cys Ser Arg Arg Ser Ser Val Thr Val
                245                 250                 255     
Glu Glu Arg Ala Arg Glu Arg Val Pro Tyr Gly Val Ser Val Val Glu
            260                 265                 270         
Arg Asn Ala Arg Val Ile Lys Trp Leu Tyr Gly Leu Arg Gln Ala Arg
        275                 280                 285             
Glu Ser Pro Ala Ala Glu Gly
    290                 295 


<210> 1749
<211> 334
<212> PRT
<213> Homo sapiens

<400> 1749
Met Gly Arg Arg Ser Ser Asp Thr Glu Glu Glu Ser Arg Ser Lys Arg
 1               5                  10                  15      
Lys Lys Lys His Arg Arg Arg Ser Ser Ser Ser Ser Ser Ser Asp Ser
            20                  25                  30          
Arg Thr Tyr Ser Arg Lys Lys Gly Gly Arg Lys Ser Arg Ser Lys Ser
        35                  40                  45              
Arg Ser Trp Ser Arg Asp Leu Gln Pro Arg Ser His Ser Tyr Asp Arg
    50                  55                  60                  
Arg Arg Arg His Arg Ser Ser Ser Ser Ser Ser Tyr Gly Ser Arg Arg
65                  70                  75                  80  
Lys Arg Ser Arg Ser Arg Ser Arg Gly Arg Gly Lys Ser Tyr Arg Val
                85                  90                  95      
Gln Arg Ser Arg Ser Lys Ser Arg Thr Arg Arg Ser Arg Ser Arg Pro
            100                 105                 110         
Arg Leu Arg Ser His Ser Arg Ser Ser Glu Arg Ser Ser His Arg Arg
        115                 120                 125             
Thr Arg Ser Arg Ser Arg Asp Arg Glu Arg Arg Lys Gly Arg Asp Lys
    130                 135                 140                 
Glu Lys Arg Glu Lys Glu Lys Asp Lys Gly Lys Asp Lys Glu Leu His
145                 150                 155                 160 
Asn Ile Lys Arg Gly Glu Ser Gly Asn Ile Lys Ala Gly Leu Glu His
                165                 170                 175     
Leu Pro Pro Ala Glu Gln Ala Lys Ala Arg Leu Gln Leu Val Leu Glu
            180                 185                 190         
Ala Ala Ala Lys Ala Asp Glu Ala Leu Lys Ala Lys Glu Arg Asn Glu
        195                 200                 205             
Glu Glu Ala Lys Arg Arg Lys Glu Glu Asp Gln Ala Thr Leu Val Glu
    210                 215                 220                 
Gln Val Lys Arg Val Lys Glu Ile Glu Ala Ile Glu Ser Asp Ser Phe
225                 230                 235                 240 
Val Gln Gln Thr Phe Arg Ser Ser Lys Glu Val Lys Lys Ser Val Glu
                245                 250                 255     
Pro Ser Glu Val Lys Gln Ala Thr Ser Thr Ser Gly Pro Ala Ser Ala
            260                 265                 270         
Val Ala Asp Pro Pro Ser Thr Glu Lys Glu Ile Asp Pro Thr Ser Ile
        275                 280                 285             
Pro Thr Ala Ile Lys Tyr Gln Asp Asp Asn Ser Leu Ala His Pro Asn
    290                 295                 300                 
Leu Phe Ile Glu Lys Ala Asp Ala Glu Glu Lys Trp Phe Lys Arg Leu
305                 310                 315                 320 
Ile Ala Leu Arg Gln Glu Arg Leu Met Gly Ser Pro Val Ala
                325                 330                 


<210> 1750
<211> 306
<212> PRT
<213> Homo sapiens

<400> 1750
Met Ala Ser Asn Val Thr Asn Lys Thr Asp Pro Arg Ser Met Asn Ser
 1               5                  10                  15      
Arg Val Phe Ile Gly Asn Leu Asn Thr Leu Val Val Lys Lys Ser Asp
            20                  25                  30          
Val Glu Ala Ile Phe Ser Lys Tyr Gly Lys Ile Val Gly Cys Ser Val
        35                  40                  45              
His Lys Gly Phe Ala Phe Val Gln Tyr Val Asn Glu Arg Asn Ala Arg
    50                  55                  60                  
Ala Ala Val Ala Gly Glu Asp Gly Arg Met Ile Ala Gly Gln Val Leu
65                  70                  75                  80  
Asp Ile Asn Leu Ala Ala Glu Pro Lys Val Asn Arg Gly Lys Ala Gly
                85                  90                  95      
Val Lys Arg Ser Ala Ala Glu Met Tyr Gly Ser Val Thr Glu His Pro
            100                 105                 110         
Ser Pro Ser Pro Leu Leu Ser Ser Ser Phe Asp Leu Asp Tyr Asp Phe
        115                 120                 125             
Gln Arg Asp Tyr Tyr Asp Arg Met Tyr Ser Tyr Pro Ala Arg Val Pro
    130                 135                 140                 
Pro Pro Pro Pro Ile Ala Arg Ala Val Val Pro Ser Lys Arg Gln Arg
145                 150                 155                 160 
Val Ser Gly Asn Thr Ser Arg Arg Gly Lys Ser Gly Phe Asn Ser Lys
                165                 170                 175     
Ser Gly Gln Arg Gly Ser Ser Lys Ser Gly Lys Leu Lys Gly Asp Asp
            180                 185                 190         
Leu Gln Ala Ile Lys Lys Glu Leu Thr Gln Ile Lys Gln Lys Val Asp
        195                 200                 205             
Ser Leu Leu Glu Asn Leu Glu Lys Ile Glu Lys Glu Gln Ser Lys Gln
    210                 215                 220                 
Ala Val Glu Met Lys Asn Asp Lys Ser Glu Glu Glu Gln Ser Ser Ser
225                 230                 235                 240 
Ser Val Lys Lys Asp Glu Thr Asn Val Lys Met Glu Ser Gly Gly Gly
                245                 250                 255     
Ala Asp Asp Ser Ala Glu Glu Gly Asp Leu Leu Asp Asp Asp Asp Asn
            260                 265                 270         
Glu Asp Arg Gly Asp Asp Gln Leu Glu Leu Ile Lys Asp Asp Glu Lys
        275                 280                 285             
Glu Ala Glu Glu Gly Glu Asp Asp Arg Asp Ser Ala Asn Gly Glu Asp
    290                 295                 300                 
Asp Ser
305     


<210> 1751
<211> 1044
<212> PRT
<213> Homo sapiens

<400> 1751
Leu Arg Thr Pro Pro Cys Pro Pro Thr Val Arg Arg Cys Arg Arg Ser
 1               5                  10                  15      
Ala Ala Ala Met Lys Ala Ser Ser Gly Asp Gln Gly Ser Pro Pro Cys
            20                  25                  30          
Phe Leu Arg Phe Pro Arg Pro Val Arg Val Val Ser Gly Ala Glu Ala
        35                  40                  45              
Glu Leu Lys Cys Val Val Leu Gly Glu Pro Pro Pro Val Val Val Trp
    50                  55                  60                  
Glu Lys Gly Gly Gln Gln Leu Ala Ala Ser Glu Arg Leu Ser Phe Pro
65                  70                  75                  80  
Ala Asp Gly Ala Glu His Gly Leu Leu Leu Thr Ala Ala Leu Pro Thr
                85                  90                  95      
Asp Ala Gly Val Tyr Val Cys Arg Ala Arg Asn Ala Ala Gly Glu Ala
            100                 105                 110         
Tyr Ala Ala Ala Ala Val Thr Val Leu Glu Pro Pro Ala Ser Asp Pro
        115                 120                 125             
Glu Leu Gln Pro Ala Glu Arg Pro Leu Pro Ser Pro Gly Ser Gly Glu
    130                 135                 140                 
Gly Ala Pro Val Phe Leu Thr Gly Pro Arg Ser Gln Trp Val Leu Arg
145                 150                 155                 160 
Gly Ala Glu Val Val Leu Thr Cys Arg Ala Gly Gly Leu Pro Glu Pro
                165                 170                 175     
Thr Leu Tyr Trp Glu Lys Asp Gly Met Ala Leu Asp Glu Val Trp Asp
            180                 185                 190         
Ser Ser His Phe Ala Leu Gln Pro Gly Arg Ala Glu Asp Gly Pro Gly
        195                 200                 205             
Ala Ser Leu Ala Leu Arg Ile Leu Ala Ala Arg Leu Pro Asp Ser Gly
    210                 215                 220                 
Val Tyr Val Cys His Ala Arg Asn Ala His Gly His Ala Gln Ala Gly
225                 230                 235                 240 
Ala Leu Leu Gln Val His Gln Pro Pro Glu Ser Pro Pro Ala Asp Pro
                245                 250                 255     
Asp Glu Ala Pro Ala Pro Val Val Glu Pro Leu Lys Cys Ala Pro Lys
            260                 265                 270         
Thr Phe Trp Val Asn Glu Gly Lys His Ala Lys Phe Arg Cys Tyr Val
        275                 280                 285             
Met Gly Lys Pro Glu Pro Glu Ile Glu Trp His Trp Glu Gly Arg Pro
    290                 295                 300                 
Leu Leu Pro Asp Arg Arg Arg Leu Met Tyr Arg Asp Arg Asp Gly Gly
305                 310                 315                 320 
Phe Val Leu Lys Val Leu Tyr Cys Gln Ala Lys Asp Arg Gly Leu Tyr
                325                 330                 335     
Val Cys Ala Ala Arg Asn Ser Ala Gly Gln Thr Leu Ser Ala Val Gln
            340                 345                 350         
Leu His Val Lys Glu Pro Arg Leu Arg Phe Thr Arg Pro Leu Gln Asp
        355                 360                 365             
Val Glu Gly Arg Glu His Gly Ile Ala Val Leu Glu Cys Lys Val Pro
    370                 375                 380                 
Asn Ser Arg Ile Pro Thr Ala Trp Phe Arg Glu Asp Gln Arg Leu Leu
385                 390                 395                 400 
Pro Cys Arg Lys Tyr Glu Gln Ile Glu Glu Gly Thr Val Arg Arg Leu
                405                 410                 415     
Ile Ile His Arg Leu Lys Ala Asp Asp Asp Gly Ile Tyr Leu Cys Glu
            420                 425                 430         
Met Arg Gly Arg Val Arg Thr Val Ala Asn Val Thr Val Lys Gly Pro
        435                 440                 445             
Ile Leu Lys Arg Leu Pro Arg Lys Leu Asp Val Leu Glu Gly Glu Asn
    450                 455                 460                 
Ala Val Leu Leu Val Glu Thr Leu Glu Ala Gly Val Glu Gly Arg Trp
465                 470                 475                 480 
Ser Arg Asp Gly Glu Glu Leu Pro Val Ile Cys Gln Ser Ser Ser Gly
                485                 490                 495     
His Met His Ala Leu Val Leu Pro Gly Val Thr Arg Glu Asp Ala Gly
            500                 505                 510         
Glu Val Thr Phe Ser Leu Gly Asn Ser Arg Thr Thr Thr Leu Leu Arg
        515                 520                 525             
Val Lys Cys Val Lys His Ser Pro Pro Gly Pro Pro Ile Leu Ala Glu
    530                 535                 540                 
Met Phe Lys Gly His Lys Asn Thr Val Leu Leu Thr Trp Lys Pro Pro
545                 550                 555                 560 
Glu Pro Ala Pro Glu Thr Pro Phe Ile Tyr Arg Leu Glu Arg Gln Glu
                565                 570                 575     
Val Gly Ser Glu Asp Trp Ile Gln Cys Phe Ser Ile Glu Lys Ala Gly
            580                 585                 590         
Ala Val Glu Val Pro Gly Asp Cys Val Pro Ser Glu Gly Asp Tyr Arg
        595                 600                 605             
Phe Arg Ile Cys Thr Val Ser Gly His Gly Arg Ser Pro His Val Val
    610                 615                 620                 
Phe His Gly Ser Ala His Leu Val Pro Thr Ala Arg Leu Val Ala Gly
625                 630                 635                 640 
Leu Glu Asp Val Gln Val Tyr Asp Gly Glu Asp Ala Val Phe Ser Leu
                645                 650                 655     
Asp Leu Ser Thr Ile Ile Gln Gly Thr Trp Phe Leu Asn Gly Glu Glu
            660                 665                 670         
Leu Lys Ser Asn Glu Pro Glu Gly Gln Val Glu Pro Gly Ala Leu Arg
        675                 680                 685             
Tyr Arg Ile Glu Gln Lys Gly Leu Gln His Arg Leu Ile Leu His Ala
    690                 695                 700                 
Val Lys His Gln Asp Ser Gly Ala Leu Val Gly Phe Ser Cys Pro Gly
705                 710                 715                 720 
Val Gln Asp Ser Ala Ala Leu Thr Ile Gln Glu Ser Pro Val His Ile
                725                 730                 735     
Leu Ser Pro Gln Asp Lys Val Ser Leu Thr Phe Thr Thr Ser Glu Arg
            740                 745                 750         
Val Val Leu Thr Cys Glu Leu Ser Arg Val Asp Phe Pro Ala Thr Trp
        755                 760                 765             
Tyr Lys Asp Gly Gln Lys Val Glu Glu Ser Glu Leu Leu Val Val Lys
    770                 775                 780                 
Met Asp Gly Arg Lys His Arg Leu Ile Leu Pro Glu Ala Lys Val Gln
785                 790                 795                 800 
Asp Ser Gly Glu Phe Glu Cys Arg Thr Glu Gly Val Ser Ala Phe Phe
                805                 810                 815     
Gly Val Thr Val Gln Asp Pro Pro Val His Ile Val Asp Pro Arg Glu
            820                 825                 830         
His Val Phe Val His Ala Ile Thr Ser Glu Cys Val Met Leu Ala Cys
        835                 840                 845             
Glu Val Asp Arg Glu Asp Ala Pro Val Arg Trp Tyr Lys Asp Gly Gln
    850                 855                 860                 
Glu Val Glu Glu Ser Asp Phe Val Val Leu Glu Asn Glu Gly Pro His
865                 870                 875                 880 
Arg Arg Leu Val Leu Pro Ala Thr Gln Pro Ser Asp Gly Gly Glu Phe
                885                 890                 895     
Gln Cys Val Ala Gly Asp Glu Cys Ala Tyr Phe Thr Val Thr Ile Thr
            900                 905                 910         
Asp Val Ser Ser Trp Ile Val Tyr Pro Ser Gly Lys Val Tyr Val Ala
        915                 920                 925             
Ala Val Arg Leu Glu Arg Val Val Leu Thr Cys Glu Leu Cys Arg Pro
    930                 935                 940                 
Trp Ala Glu Val Arg Trp Thr Lys Asp Gly Glu Glu Val Val Glu Ser
945                 950                 955                 960 
Pro Ala Leu Leu Leu Gln Lys Glu Asp Thr Val Arg Arg Leu Val Leu
                965                 970                 975     
Pro Ala Val Gln Leu Glu Asp Ser Gly Glu Tyr Leu Cys Glu Ile Asp
            980                 985                 990         
Asp Glu Ser Ala Ser Phe Thr Val Thr Val Thr Glu Ser Tyr Gln Ser
        995                 1000                1005            
Gln Asp Ser Ser Asn Asn Asn Pro Glu Leu Cys Val Leu Leu Lys Lys
    1010                1015                1020                
Pro Lys Thr Arg Arg Leu Trp Ser Arg Phe Pro Pro Trp Arg Arg Thr
1025                1030                1035                1040
Ala Gly Thr Glu
                


<210> 1752
<211> 48
<212> PRT
<213> Homo sapiens

<400> 1752
Met Ser Arg Lys Pro Arg Ala Ser Ser Pro Leu Ser Asn Asn His Pro
 1               5                  10                  15      
Pro Thr Pro Lys Arg Arg Gly Ser Gly Arg Phe Pro Arg Gln Pro Gly
            20                  25                  30          
Arg Glu Lys Gly Pro Ile Lys Glu Val Pro Gly Thr Lys Gly Ser Pro
        35                  40                  45              


<210> 1753
<211> 586
<212> PRT
<213> Homo sapiens

<400> 1753
Met Asn Pro Thr Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg
 1               5                  10                  15      
Arg Phe Asp Asp Ala Val Val Gln Ser Asp Met Lys His Trp Pro Phe
            20                  25                  30          
Met Val Val Asn Asp Ala Gly Arg Pro Lys Val Gln Val Glu Tyr Lys
        35                  40                  45              
Gly Glu Thr Lys Ser Phe Tyr Pro Glu Glu Val Ser Ser Met Val Leu
    50                  55                  60                  
Thr Lys Met Lys Glu Ile Ala Glu Ala Tyr Leu Gly Lys Thr Val Thr
65                  70                  75                  80  
Asn Ala Val Val Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln
                85                  90                  95      
Ala Thr Lys Asp Ala Gly Thr Ile Ala Gly Leu Asn Val Leu Arg Ile
            100                 105                 110         
Ile Asn Glu Pro Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Lys Lys
        115                 120                 125             
Val Gly Ala Glu Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr
    130                 135                 140                 
Phe Asp Val Ser Ile Leu Thr Ile Glu Asp Gly Ile Phe Glu Val Lys
145                 150                 155                 160 
Ser Thr Ala Gly Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg
                165                 170                 175     
Met Val Asn His Phe Ile Ala Glu Phe Lys Arg Lys His Lys Lys Asp
            180                 185                 190         
Ile Ser Glu Asn Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu
        195                 200                 205             
Arg Ala Lys Arg Thr Leu Ser Ser Ser Thr Gln Ala Ser Ile Glu Ile
    210                 215                 220                 
Asp Ser Leu Tyr Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala
225                 230                 235                 240 
Arg Phe Glu Glu Leu Asn Ala Asp Leu Phe Arg Gly Thr Leu Asp Pro
                245                 250                 255     
Val Glu Lys Ala Leu Arg Asp Ala Lys Leu Asp Lys Ser Gln Ile His
            260                 265                 270         
Asp Ile Val Leu Val Gly Gly Ser Thr Arg Ile Pro Lys Ile Gln Lys
        275                 280                 285             
Leu Leu Gln Asp Phe Phe Asn Gly Lys Glu Leu Asn Lys Ser Ile Asn
    290                 295                 300                 
Pro Asp Glu Ala Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu
305                 310                 315                 320 
Ser Gly Asp Lys Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val
                325                 330                 335     
Thr Pro Leu Ser Leu Gly Ile Glu Thr Ala Gly Gly Val Met Thr Val
            340                 345                 350         
Leu Ile Lys Arg Asn Thr Thr Ile Pro Thr Lys Gln Thr Gln Thr Phe
        355                 360                 365             
Thr Thr Tyr Ser Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu
    370                 375                 380                 
Gly Glu Arg Ala Met Thr Lys Asp Asn Asn Leu Leu Gly Lys Phe Glu
385                 390                 395                 400 
Leu Thr Gly Ile Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val
                405                 410                 415     
Thr Phe Asp Ile Asp Ala Asn Gly Ile Leu Asn Val Ser Ala Val Asp
            420                 425                 430         
Lys Ser Thr Gly Lys Glu Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly
        435                 440                 445             
Arg Leu Ser Lys Glu Asp Ile Glu Arg Met Val Gln Glu Ala Glu Lys
    450                 455                 460                 
Tyr Lys Ala Glu Asp Glu Lys Gln Arg Asp Lys Val Ser Ser Lys Asn
465                 470                 475                 480 
Ser Leu Glu Ser Tyr Ala Phe Asn Met Lys Ala Thr Val Glu Asp Glu
                485                 490                 495     
Lys Leu Gln Gly Lys Ile Asn Asp Glu Asp Lys Gln Lys Ile Leu Asp
            500                 505                 510         
Lys Cys Asn Glu Ile Ile Asn Trp Leu Asp Lys Asn Gln Thr Ala Glu
        515                 520                 525             
Lys Glu Glu Phe Glu His Gln Gln Lys Glu Leu Glu Lys Val Cys Asn
    530                 535                 540                 
Pro Ile Ile Thr Lys Leu Tyr Gln Ser Ala Gly Gly Met Pro Gly Gly
545                 550                 555                 560 
Met Pro Gly Gly Phe Pro Gly Gly Gly Ala Pro Pro Ser Gly Gly Ala
                565                 570                 575     
Ser Ser Gly Pro Thr Ile Glu Glu Val Asp
            580                 585     


<210> 1754
<211> 178
<212> PRT
<213> Homo sapiens

<400> 1754
Met Phe Ile Ile Ser Ile Asn Ser Pro Val Ser Gly Ser Asn Val Ala
 1               5                  10                  15      
Arg Thr Gly Leu Phe Gly Leu Ser Ala Arg Arg Leu Leu Ala Ala Ala
            20                  25                  30          
Ala Thr Arg Gly Leu Pro Ala Ala Arg Val Arg Trp Glu Ser Ser Phe
        35                  40                  45              
Ser Arg Thr Val Val Ala Pro Ser Ala Val Ala Gly Lys Arg Pro Pro
    50                  55                  60                  
Glu Pro Thr Thr Pro Trp Gln Glu Asp Pro Glu Pro Glu Asp Glu Asn
65                  70                  75                  80  
Leu Tyr Glu Lys Asn Pro Asp Ser His Gly Tyr Asp Lys Asp Pro Val
                85                  90                  95      
Leu Asp Val Trp Asn Met Arg Leu Val Phe Phe Phe Gly Val Ser Ile
            100                 105                 110         
Ile Leu Val Leu Gly Ser Thr Phe Val Ala Tyr Leu Pro Asp Tyr Arg
        115                 120                 125             
Cys Thr Gly Cys Pro Arg Ala Trp Asp Gly Met Lys Glu Trp Ser Arg
    130                 135                 140                 
Arg Glu Ala Glu Arg Leu Val Lys Tyr Arg Glu Ala Asn Gly Leu Pro
145                 150                 155                 160 
Ile Met Glu Ser Asn Cys Phe Asp Pro Ser Lys Ile Gln Leu Pro Glu
                165                 170                 175     
Asp Glu
        


<210> 1755
<211> 521
<212> PRT
<213> Homo sapiens

<400> 1755
Ala Arg Gly Gly Asn Asp Trp Ala Thr Ile Gly Ala Ala Leu Gly Arg
 1               5                  10                  15      
Ser Ala Ser Ser Val Lys Asp Arg Cys Arg Leu Met Lys Asp Thr Cys
            20                  25                  30          
Asn Thr Gly Lys Trp Thr Glu Glu Glu Glu Lys Arg Leu Ala Glu Val
        35                  40                  45              
Val His Glu Leu Thr Ser Thr Glu Pro Gly Asp Ile Val Thr Gln Gly
    50                  55                  60                  
Val Ser Trp Ala Ala Val Ala Glu Arg Val Gly Thr Arg Ser Glu Lys
65                  70                  75                  80  
Gln Cys Arg Ser Lys Trp Leu Asn Tyr Leu Asn Trp Lys Gln Ser Gly
                85                  90                  95      
Gly Thr Glu Trp Thr Lys Glu Asp Glu Ile Asn Leu Ile Leu Arg Ile
            100                 105                 110         
Ala Glu Leu Asp Val Ala Asp Glu Asn Asp Ile Asn Trp Asp Leu Leu
        115                 120                 125             
Ala Glu Gly Trp Ser Ser Val Arg Ser Pro Gln Trp Leu Arg Ser Lys
    130                 135                 140                 
Trp Trp Thr Ile Lys Arg Gln Ile Ala Asn His Lys Asp Val Ser Phe
145                 150                 155                 160 
Pro Val Leu Ile Lys Gly Leu Lys Gln Leu His Glu Asn Gln Lys Asn
                165                 170                 175     
Asn Pro Thr Leu Leu Glu Asn Lys Ser Gly Ser Gly Val Pro Asn Ser
            180                 185                 190         
Asn Thr Asn Ser Ser Val Gln His Val Gln Ile Arg Val Ala Arg Leu
        195                 200                 205             
Glu Asp Asn Thr Ala Ile Ser Ser Ser Pro Met Ala Ala Leu Gln Ile
    210                 215                 220                 
Pro Val Gln Ile Thr His Val Ser Ser Ala Asp Ser Pro Ala Thr Val
225                 230                 235                 240 
Asp Ser Glu Thr Ile Thr Leu Asn Ser Gly Thr Leu Gln Thr Phe Glu
                245                 250                 255     
Ile Leu Pro Ser Phe His Leu Gln Pro Thr Gly Thr Pro Gly Thr Tyr
            260                 265                 270         
Leu Leu Gln Thr Ser Ser Ser Gln Gly Leu Pro Leu Thr Leu Thr Ala
        275                 280                 285             
Ser Pro Thr Val Thr Leu Thr Ala Ala Ala Pro Ala Ser Pro Glu Gln
    290                 295                 300                 
Ile Ile Val His Ala Leu Ser Pro Glu His Leu Leu Asn Thr Ser Asp
305                 310                 315                 320 
Asn Val Thr Val Gln Cys His Thr Pro Arg Val Ile Ile Gln Thr Val
                325                 330                 335     
Ala Thr Glu Asp Ile Thr Ser Ser Ile Ser Gln Ala Glu Leu Thr Val
            340                 345                 350         
Asp Ser Asp Ile Gln Ser Ser Asp Phe Pro Glu Pro Pro Asp Ala Leu
        355                 360                 365             
Glu Ala Asp Thr Phe Pro Asp Glu Ile His His Pro Lys Met Thr Val
    370                 375                 380                 
Glu Pro Ser Phe Asn Asp Ala His Val Ser Lys Phe Ser Asp Gln Asn
385                 390                 395                 400 
Ser Thr Glu Leu Met Asn Ser Val Met Val Arg Thr Glu Glu Glu Ile
                405                 410                 415     
Ser Asp Thr Asp Leu Lys Gln Glu Glu Ser Pro Ser Asp Leu Ala Ser
            420                 425                 430         
Ala Tyr Val Thr Glu Gly Leu Glu Ser Pro Thr Ile Glu Glu Gln Val
        435                 440                 445             
Asp Gln Thr Ile Asp Asp Glu Thr Ile Leu Ile Val Pro Ser Pro His
    450                 455                 460                 
Gly Phe Ile Gln Ala Ser Asp Val Ile Asp Thr Glu Ser Val Leu Pro
465                 470                 475                 480 
Leu Thr Thr Leu Thr Asp Pro Ile Leu Gln His His Gln Glu Glu Ser
                485                 490                 495     
Asn Ile Ile Gly Ser Ser Leu Gly Ser Pro Val Ser Glu Asp Ser Lys
            500                 505                 510         
Asp Val Glu Asp Leu Val Asn Cys His
        515                 520     


<210> 1756
<211> 260
<212> PRT
<213> Homo sapiens

<400> 1756
Ala Arg Gly Pro Phe Leu Pro Arg Pro Pro Gln Pro Leu Leu Tyr Gln
 1               5                  10                  15      
Arg Gly Pro Ser Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro Pro Ser
            20                  25                  30          
Pro Pro Pro Pro Leu Pro Pro Trp Gly Pro Pro Pro Ser Pro Pro Pro
        35                  40                  45              
Ser Pro Pro Leu His Val Leu Gly Leu Leu Ser Trp Arg Arg Ser Tyr
    50                  55                  60                  
Ser Arg Ser Pro Leu Trp Ala Arg Gly Ala Ala Met Ala Asp Gly Gly
65                  70                  75                  80  
Gly Gly Gly Gly Thr Gly Ala Val Gly Gly Gly Gly Thr Ser Gln Ala
                85                  90                  95      
Ser Ala Gly Ala Ala Thr Gly Ala Thr Gly Ala Ser Gly Gly Gly Gly
            100                 105                 110         
Pro Ile Asn Pro Ala Ser Leu Pro Pro Gly Asp Pro Gln Leu Ile Ala
        115                 120                 125             
Leu Ile Val Glu Gln Leu Lys Ser Arg Gly Leu Phe Asp Ser Phe Arg
    130                 135                 140                 
Arg Asp Cys Leu Ala Asp Val Asp Thr Lys Pro Ala Tyr Gln Asn Leu
145                 150                 155                 160 
Arg Gln Lys Val Asp Asn Phe Val Ser Thr His Leu Asp Lys Gln Glu
                165                 170                 175     
Trp Asn Pro Thr Met Asn Lys Asn Gln Leu Arg Asn Gly Leu Arg Gln
            180                 185                 190         
Ser Val Val Gln Ser Gly Met Leu Glu Ala Gly Val Asp Arg Ile Ile
        195                 200                 205             
Ser Gln Val Val Asp Pro Lys Leu Asn His Ile Phe Arg Pro Gln Ile
    210                 215                 220                 
Glu Arg Ala Ile His Glu Phe Leu Ala Ala Gln Lys Lys Ala Ala Val
225                 230                 235                 240 
Pro Ala Pro Pro Pro Glu Pro Glu Gly Gln Asp Pro Pro Ala Pro Ser
                245                 250                 255     
Gln Asp Thr Ser
            260 


<210> 1757
<211> 404
<212> PRT
<213> Homo sapiens

<400> 1757
Met Ala Gly Arg Arg Ala Gln Pro Gly Ser Ala Pro Pro Arg Pro Ala
 1               5                  10                  15      
Ala Pro His Pro Arg Pro Ala Ser Arg Ala Phe Pro Gln His Cys Arg
            20                  25                  30          
Pro Arg Asp Ala Glu Arg Pro Pro Ser Pro Arg Ser Pro Leu Met Pro
        35                  40                  45              
Gly Cys Glu Leu Pro Val Gly Thr Cys Pro Asp Met Cys Pro Ala Ala
    50                  55                  60                  
Glu Arg Ala Gln Arg Glu Arg Glu His Arg Leu His Arg Leu Glu Val
65                  70                  75                  80  
Val Pro Gly Cys Arg Gln Asp Pro Pro Arg Ala Asp Pro Gln Arg Ala
                85                  90                  95      
Val Lys Glu Tyr Ser Arg Pro Ala Ala Gly Lys Pro Arg Pro Pro Pro
            100                 105                 110         
Ser Gln Leu Arg Pro Pro Ser Val Leu Leu Ala Thr Val Arg Tyr Leu
        115                 120                 125             
Ala Gly Glu Val Ala Glu Ser Ala Asp Ile Ala Arg Ala Glu Val Ala
    130                 135                 140                 
Ser Phe Val Ala Asp Arg Leu Arg Ala Val Arg Leu Asp Leu Ala Leu
145                 150                 155                 160 
Gln Gly Ala Gly Asp Ala Glu Ala Ala Val Val Leu Glu Ala Ala Leu
                165                 170                 175     
Ala Thr Leu Leu Ala Val Val Ala Arg Leu Gly Pro Asp Ala Ala Arg
            180                 185                 190         
Gly Pro Ala Asp Pro Val Leu Leu Gln Ala Gln Val Gln Glu Gly Phe
        195                 200                 205             
Gly Ser Leu Arg Arg Cys Tyr Ala Arg Gly Ala Gly Pro His Pro Arg
    210                 215                 220                 
Gln Pro Ala Phe Gln Gly Leu Phe Leu Leu Tyr Asn Leu Gly Ser Val
225                 230                 235                 240 
Glu Ala Leu His Glu Val Leu Gln Leu Pro Ala Ala Leu Arg Ala Cys
                245                 250                 255     
Pro Pro Leu Arg Lys Ala Leu Ala Val Asp Ala Ala Phe Arg Glu Gly
            260                 265                 270         
Asn Ala Ala Arg Leu Phe Arg Leu Leu Gln Thr Leu Pro Tyr Leu Pro
        275                 280                 285             
Ser Cys Ala Val Gln Cys His Val Gly His Ala Arg Arg Glu Ala Leu
    290                 295                 300                 
Ala Arg Phe Ala Arg Ala Phe Ser Thr Pro Lys Gly Gln Thr Leu Pro
305                 310                 315                 320 
Leu Gly Phe Met Val Asn Leu Leu Ala Leu Asp Gly Leu Arg Glu Ala
                325                 330                 335     
Arg Asp Leu Cys Gln Ala His Gly Leu Pro Leu Asp Gly Glu Glu Arg
            340                 345                 350         
Val Val Phe Leu Arg Gly Arg Tyr Val Glu Glu Gly Leu Pro Pro Ala
        355                 360                 365             
Ser Thr Cys Lys Val Leu Val Glu Ser Lys Leu Arg Gly Arg Thr Leu
    370                 375                 380                 
Glu Glu Val Val Met Ala Glu Glu Glu Asp Glu Gly Thr Asp Arg Pro
385                 390                 395                 400 
Gly Ser Pro Ala
                


<210> 1758
<211> 381
<212> PRT
<213> Homo sapiens

<400> 1758
Met Pro Phe Gly Asn Thr His Asn Lys Phe Lys Leu Asn Tyr Lys Pro
 1               5                  10                  15      
Glu Glu Glu Tyr Pro Asp Leu Ser Lys His Asn Asn His Met Ala Lys
            20                  25                  30          
Val Leu Thr Leu Glu Leu Tyr Lys Lys Leu Arg Asp Lys Glu Thr Pro
        35                  40                  45              
Ser Gly Phe Thr Val Asp Asp Val Ile Gln Thr Gly Val Asp Asn Pro
    50                  55                  60                  
Gly His Pro Phe Ile Met Thr Val Gly Cys Val Ala Gly Asp Glu Glu
65                  70                  75                  80  
Ser Tyr Glu Val Phe Lys Glu Leu Phe Asp Pro Ile Ile Ser Asp Arg
                85                  90                  95      
His Gly Gly Tyr Lys Pro Thr Asp Lys His Lys Thr Asp Leu Asn His
            100                 105                 110         
Glu Asn Leu Lys Gly Gly Asp Asp Leu Asp Pro Asn Tyr Val Leu Ser
        115                 120                 125             
Ser Arg Val Arg Thr Gly Arg Ser Ile Lys Gly Tyr Thr Leu Pro Pro
    130                 135                 140                 
His Cys Ser Arg Gly Glu Arg Arg Ala Val Glu Lys Leu Ser Val Glu
145                 150                 155                 160 
Ala Leu Asn Ser Leu Thr Gly Glu Phe Lys Gly Lys Tyr Tyr Pro Leu
                165                 170                 175     
Lys Ser Met Thr Glu Lys Glu Gln Gln Gln Leu Ile Asp Asp His Phe
            180                 185                 190         
Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Leu Ala Ser Gly Met Ala
        195                 200                 205             
Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Asp Asn Lys Ser
    210                 215                 220                 
Leu Leu Val Trp Val Asn Glu Glu Asp His Leu Arg Val Ile Ser Met
225                 230                 235                 240 
Glu Lys Gly Gly Asn Met Lys Glu Val Phe Arg Arg Phe Cys Val Gly
                245                 250                 255     
Leu Gln Lys Ile Glu Glu Ile Phe Lys Lys Ala Gly His Pro Phe Met
            260                 265                 270         
Trp Asn Gln His Leu Gly Tyr Val Leu Thr Cys Pro Ser Asn Leu Gly
        275                 280                 285             
Thr Gly Leu Arg Gly Gly Val His Val Lys Leu Ala His Leu Ser Lys
    290                 295                 300                 
His Pro Lys Phe Glu Glu Ile Leu Thr Arg Leu Arg Leu Gln Lys Arg
305                 310                 315                 320 
Gly Thr Gly Gly Val Asp Thr Ala Ala Val Gly Ser Val Phe Asp Val
                325                 330                 335     
Ser Asn Ala Asp Arg Leu Gly Ser Ser Glu Val Glu Gln Val Gln Leu
            340                 345                 350         
Val Val Asp Gly Val Lys Leu Met Val Glu Met Glu Lys Lys Leu Glu
        355                 360                 365             
Lys Gly Gln Ser Ile Asp Asp Met Ile Pro Ala Gln Lys
    370                 375                 380     


<210> 1759
<211> 999
<212> PRT
<213> Homo sapiens

<400> 1759
Met Glu Asn Leu Glu Ser Arg Leu Lys Asn Ala Pro Tyr Phe Arg Cys
 1               5                  10                  15      
Glu Lys Gly Thr Asp Ser Asn Pro Leu Cys Arg Lys Cys Glu Thr Cys
            20                  25                  30          
Val Leu Ala Trp Lys Ile Phe Ser Thr Lys Glu Trp Phe Cys Arg Ile
        35                  40                  45              
Asn Asp Ile Ser Gln Arg Arg Phe Leu Val Gly Ile Leu Lys Gln Leu
    50                  55                  60                  
Asn Ser Leu Tyr Leu Leu His Tyr Phe Gln Asn Ile Leu Gln Thr Thr
65                  70                  75                  80  
Gln Gly Lys Asp Phe Ile Tyr Asn Arg Ser Arg Ile Asn Leu Ser Lys
                85                  90                  95      
Lys Glu Gly Lys Val Val Lys Ser Ser Leu Asn Gln Met Leu Asp Lys
            100                 105                 110         
Thr Val Glu Gln Lys Met Lys Glu Ile Leu Tyr Trp Phe Ala Asn Ser
        115                 120                 125             
Thr Gln Trp Thr Lys Ala Asn Tyr Thr Leu Leu Leu Leu Gln Met Cys
    130                 135                 140                 
Asn Pro Lys Leu Leu Leu Thr Ala Ala Asn Val Ile Arg Val Leu Phe
145                 150                 155                 160 
Leu Arg Glu Glu Asn Asn Ile Ser Gly Leu Asn Gln Asp Ile Thr Asp
                165                 170                 175     
Val Cys Phe Ser Pro Glu Lys Asp His Ser Ser Lys Ser Ala Thr Ser
            180                 185                 190         
Gln Val Tyr Trp Thr Ala Lys Thr Gln His Thr Ser Leu Pro Leu Ser
        195                 200                 205             
Lys Ala Pro Glu Asn Glu His Leu Leu Gly Ala Ala Ser Asn Pro Glu
    210                 215                 220                 
Glu Pro Trp Arg Asn Ser Leu Arg Cys Ile Ser Lys Met Asn Arg Leu
225                 230                 235                 240 
Phe Ser Gly Lys Gly Asp Ile Thr Lys Pro Gly Tyr Asp Pro Cys Asn
                245                 250                 255     
Leu Leu Val Asp Leu Asp Asp Ile Arg Asp Leu Ser Ser Gly Phe Ser
            260                 265                 270         
Lys Tyr Arg Asp Phe Ile Arg Tyr Leu Pro Ile His Leu Ser Lys Tyr
        275                 280                 285             
Ile Leu Arg Met Leu Asp Arg His Thr Leu Asn Lys Cys Ala Ser Val
    290                 295                 300                 
Ser Gln His Trp Ala Ala Met Ala Gln Gln Val Lys Met Asp Leu Ser
305                 310                 315                 320 
Ala His Gly Phe Ile Gln Asn Gln Ile Thr Phe Leu Gln Gly Ser Tyr
                325                 330                 335     
Thr Arg Gly Ile Asp Pro Asn Tyr Ala Asn Lys Val Ser Ile Pro Val
            340                 345                 350         
Pro Lys Met Val Asp Asp Gly Lys Ser Met Arg Val Lys His Pro Lys
        355                 360                 365             
Trp Lys Leu Arg Thr Lys Asn Glu Tyr Asn Leu Trp Thr Ala Tyr Gln
    370                 375                 380                 
Asn Glu Glu Thr Gln Gln Val Leu Ile Glu Glu Arg Asn Val Phe Cys
385                 390                 395                 400 
Gly Thr Tyr Asn Val Arg Ile Leu Ser Asp Thr Trp Val Gln Asn Arg
                405                 410                 415     
Val Ile His Tyr Ser Gly Gly Asp Leu Ile Ala Val Ser Ser Asn Arg
            420                 425                 430         
Lys Ile His Leu Leu Asp Ile Ile Gln Val Lys Ala Ile Pro Val Glu
        435                 440                 445             
Phe Arg Gly His Ala Gly Ser Val Arg Ala Leu Phe Leu Cys Glu Glu
    450                 455                 460                 
Glu Asn Phe Leu Leu Ser Gly Ser Tyr Asp Leu Ser Ile Arg Tyr Trp
465                 470                 475                 480 
Asp Leu Lys Ser Gly Val Cys Thr Arg Ile Phe Gly Gly His Gln Gly
                485                 490                 495     
Thr Ile Thr Cys Met Asp Leu Cys Lys Asn Arg Leu Val Ser Gly Gly
            500                 505                 510         
Arg Asp Cys Gln Val Lys Val Trp Asp Val Asp Thr Gly Lys Cys Leu
        515                 520                 525             
Lys Thr Phe Arg His Lys Asp Pro Ile Leu Ala Thr Arg Ile Asn Asp
    530                 535                 540                 
Thr Tyr Ile Val Ser Ser Cys Glu Arg Gly Leu Val Lys Val Trp His
545                 550                 555                 560 
Ile Ala Met Ala Gln Leu Val Lys Thr Leu Ser Gly His Glu Gly Ala
                565                 570                 575     
Val Lys Cys Leu Phe Phe Asp Gln Trp His Leu Leu Ser Gly Ser Thr
            580                 585                 590         
Asp Gly Leu Val Met Ala Trp Ser Met Val Gly Lys Tyr Glu Arg Cys
        595                 600                 605             
Leu Met Ala Phe Lys His Pro Lys Met Val Val Asn Thr Glu Ser Asn
    610                 615                 620                 
Val Leu Met Phe Gln Phe Glu His Ile Lys Trp Gln Tyr Ala Val Glu
625                 630                 635                 640 
Lys Thr Lys Gln Lys Lys Asn Lys Glu Lys Glu Glu Glu Lys Glu Glu
                645                 650                 655     
Asn Ser Leu Met Glu Ile Leu Ser Lys Cys Asn Ile Gln Val His Ser
            660                 665                 670         
Pro Arg Glu Ser Val Ser Ser Lys Gln Thr Val Ile Gln Glu Leu Leu
        675                 680                 685             
Pro Gly Lys Pro Pro Lys Ser Arg Val Leu Leu Lys Pro Ala Lys Phe
    690                 695                 700                 
Ser Ser Ala Val Leu Ile Glu Glu Leu Gln Ser Gln Gly Lys Ser Lys
705                 710                 715                 720 
Ser Pro Arg Arg Asp Ala Asp Asp Val Glu Lys Ala Gln Lys Gln Gly
                725                 730                 735     
Gln Leu Glu Thr Pro Gly Lys Leu Pro Ser His Pro Lys Lys Lys Ser
            740                 745                 750         
Trp Lys Ile Pro Met Ser Pro Asp Gln Phe Leu Leu Thr Val Ser Thr
        755                 760                 765             
Leu Gln His Ala His Asn Ser Gly Glu Phe Ala Tyr Pro Cys Arg Pro
    770                 775                 780                 
Gln Thr Glu Ile Thr Asp Val Trp Gly Pro Ser Ile Ser Tyr Pro Arg
785                 790                 795                 800 
Lys Val Leu Asn Phe Lys Gly Lys Ser Ile Gln Arg Ala Val Asp Arg
                805                 810                 815     
Leu Arg Leu Ser Asn Pro Pro Ile Asp Val Lys Arg Thr Ser Ile Pro
            820                 825                 830         
Leu Glu Ile Gln Lys Leu Gln Pro Asn Leu Lys Ile Ser Leu His Ser
        835                 840                 845             
Pro Arg Val Gln Ser Thr Ile Pro Gln Pro Met Ile Ile Arg Ser Arg
    850                 855                 860                 
Phe Ser Gly Ser Leu Lys Gly Gly Asp Gln Val Thr Ser Ser Ile Glu
865                 870                 875                 880 
Arg Ala Val Cys Ser Thr Gly Pro Leu Thr Ser Met Gln Val Ile Lys
                885                 890                 895     
Pro Asn Arg Met Leu Ala Pro Gln Val Gly Thr Ala Thr Leu Ser Leu
            900                 905                 910         
Lys Lys Glu Arg Pro Arg Ile Tyr Thr Ala Leu Asp Pro Phe Arg Val
        915                 920                 925             
Asn Thr Glu Phe Val Leu Leu Thr Val Lys Glu Glu Lys Glu His Gln
    930                 935                 940                 
Glu Ala Lys Met Lys Glu Tyr Gln Ala Arg Glu Ser Thr Gly Val Val
945                 950                 955                 960 
Asp Pro Gly Lys Val Ser Lys Ala Ala Trp Ile Arg Lys Ile Lys Gly
                965                 970                 975     
Leu Pro Ile Asp Asn Phe Thr Lys Gln Gly Lys Thr Ala Ala Pro Glu
            980                 985                 990         
Leu Gly Gln Asn Val Phe Ile
        995                 


<210> 1760
<211> 230
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 177
<223> Xaa = Any Amino Acid

<400> 1760
Met Pro Leu Pro Asp Thr Met Phe Cys Ala Gln Gln Ile His Ile Pro
 1               5                  10                  15      
Pro Glu Leu Pro Asp Ile Leu Lys Gln Phe Thr Lys Ala Ala Ile Arg
            20                  25                  30          
Thr Gln Pro Ala Asp Val Leu Arg Trp Ser Ala Gly Tyr Phe Ser Ala
        35                  40                  45              
Leu Ser Arg Gly Asp Pro Leu Pro Val Lys Asp Arg Met Glu Met Pro
    50                  55                  60                  
Thr Ala Thr Gln Lys Thr Asp Thr Gly Leu Thr Gln Gly Leu Leu Lys
65                  70                  75                  80  
Val Leu His Lys Gln Cys His His Lys Arg Tyr Val Glu Leu Thr Asp
                85                  90                  95      
Leu Glu Gln Lys Trp Lys Asn Leu Cys Leu Pro Lys Glu Lys Phe Lys
            100                 105                 110         
Ala Leu Leu Gln Leu Asp Pro Cys Glu Asn Lys Ile Lys Trp Ile Asn
        115                 120                 125             
Phe Leu Ala Leu Gly Cys Ser Met Leu Gly Gly Ser Leu Asn Thr Ala
    130                 135                 140                 
Leu Lys His Leu Cys Glu Ile Leu Thr Asp Asp Pro Glu Gly Gly Pro
145                 150                 155                 160 
Ala Arg Ile Pro Phe Lys Thr Phe Ser Tyr Val Tyr Arg Tyr Leu Ala
                165                 170                 175     
Xaa Leu Asp Ser Asp Val Ser Pro Leu Glu Thr Glu Ser Tyr Leu Ala
            180                 185                 190         
Ser Leu Lys Glu Asn Ile Asp Ala Arg Lys Asn Gly Met Ile Gly Leu
        195                 200                 205             
Ser Asp Phe Phe Phe Pro Lys Arg Lys Leu Leu Glu Ser Ile Glu Asn
    210                 215                 220                 
Ser Glu Asp Val Gly His
225                 230 


<210> 1761
<211> 430
<212> PRT
<213> Homo sapiens

<400> 1761
Met Ala Thr Ala Val Arg Ala Val Gly Cys Leu Pro Val Leu Cys Ser
 1               5                  10                  15      
Gly Thr Ala Gly His Leu Leu Gly Arg Gln Cys Ser Leu Asn Thr Leu
            20                  25                  30          
Pro Ala Ala Ser Ile Leu Ala Trp Lys Ser Val Leu Gly Asn Gly His
        35                  40                  45              
Leu Ser Ser Leu Gly Thr Arg Asp Thr His Pro Tyr Ala Ser Leu Ser
    50                  55                  60                  
Arg Ala Leu Gln Thr Gln Cys Cys Ile Ser Ser Pro Ser His Leu Met
65                  70                  75                  80  
Ser Gln Gln Tyr Arg Pro Tyr Ser Phe Phe Thr Lys Leu Thr Ala Asp
                85                  90                  95      
Glu Leu Trp Lys Gly Ala Leu Ala Glu Thr Gly Ala Gly Ala Lys Lys
            100                 105                 110         
Gly Arg Gly Lys Arg Thr Lys Lys Lys Lys Arg Lys Asp Leu Asn Arg
        115                 120                 125             
Gly Gln Ile Ile Gly Glu Gly Arg Tyr Gly Phe Leu Trp Pro Gly Leu
    130                 135                 140                 
Asn Val Pro Leu Met Lys Asn Gly Ala Val Gln Thr Ile Ala Gln Arg
145                 150                 155                 160 
Ser Lys Glu Glu Gln Glu Lys Val Glu Ala Asp Met Ile Gln Gln Arg
                165                 170                 175     
Glu Glu Trp Asp Arg Lys Lys Lys Met Lys Val Lys Arg Glu Arg Gly
            180                 185                 190         
Trp Ser Gly Asn Ser Trp Gly Gly Ile Ser Leu Gly Pro Pro Asp Pro
        195                 200                 205             
Gly Pro Cys Gly Glu Thr Tyr Glu Asp Phe Asp Thr Arg Ile Leu Glu
    210                 215                 220                 
Val Arg Asn Val Phe Thr Met Thr Ala Lys Glu Gly Arg Lys Lys Ser
225                 230                 235                 240 
Ile Arg Val Leu Val Ala Val Gly Asn Gly Lys Gly Ala Ala Gly Phe
                245                 250                 255     
Ser Ile Gly Lys Ala Thr Asp Arg Met Asp Ala Phe Arg Lys Ala Lys
            260                 265                 270         
Asn Arg Ala Val His His Leu His Tyr Ile Glu Arg Tyr Glu Asp His
        275                 280                 285             
Thr Ile Phe His Asp Ile Ser Leu Arg Phe Lys Arg Thr His Ile Lys
    290                 295                 300                 
Met Lys Lys Gln Pro Lys Gly Tyr Gly Leu Arg Cys His Arg Ala Ile
305                 310                 315                 320 
Ile Thr Ile Cys Arg Leu Ile Gly Ile Lys Asp Met Tyr Ala Lys Val
                325                 330                 335     
Ser Gly Ser Ile Asn Met Leu Ser Leu Thr Gln Gly Leu Phe Arg Gly
            340                 345                 350         
Leu Ser Arg Gln Glu Thr His Gln Gln Leu Ala Asp Lys Lys Gly Leu
        355                 360                 365             
His Val Val Glu Ile Arg Glu Glu Cys Gly Pro Leu Pro Ile Val Val
    370                 375                 380                 
Ala Ser Pro Arg Gly Pro Leu Arg Lys Asp Pro Glu Pro Glu Asp Glu
385                 390                 395                 400 
Val Pro Asp Val Lys Leu Asp Trp Glu Asp Val Lys Thr Ala Gln Gly
                405                 410                 415     
Met Lys Arg Ser Val Trp Ser Asn Leu Lys Arg Ala Ala Thr
            420                 425                 430 


<210> 1762
<211> 289
<212> PRT
<213> Homo sapiens

<400> 1762
Met Phe Val Leu Leu Tyr Val Thr Ser Phe Ala Ile Cys Ala Ser Gly
 1               5                  10                  15      
Gln Pro Arg Gly Asn Gln Leu Lys Gly Glu Asn Tyr Ser Pro Arg Tyr
            20                  25                  30          
Ile Cys Ser Ile Pro Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Ala
        35                  40                  45              
Asn Gly Ser Pro Gly Pro His Gly Arg Ile Gly Leu Pro Gly Arg Asp
    50                  55                  60                  
Gly Arg Asp Gly Arg Lys Gly Glu Lys Gly Glu Lys Gly Thr Ala Gly
65                  70                  75                  80  
Leu Arg Gly Lys Thr Gly Pro Leu Gly Leu Ala Gly Glu Lys Gly Asp
                85                  90                  95      
Gln Gly Glu Thr Gly Lys Lys Gly Pro Ile Gly Pro Glu Gly Glu Lys
            100                 105                 110         
Gly Glu Val Gly Pro Ile Gly Pro Pro Gly Pro Lys Gly Asp Arg Gly
        115                 120                 125             
Glu Gln Gly Asp Pro Gly Leu Pro Gly Val Cys Arg Cys Gly Ser Ile
    130                 135                 140                 
Val Leu Lys Ser Ala Phe Ser Val Gly Ile Thr Thr Ser Tyr Pro Glu
145                 150                 155                 160 
Glu Arg Leu Pro Ile Ile Phe Asn Lys Val Leu Phe Asn Glu Gly Glu
                165                 170                 175     
His Tyr Asn Pro Ala Thr Gly Lys Phe Ile Cys Ala Phe Pro Gly Ile
            180                 185                 190         
Tyr Tyr Phe Ser Tyr Asp Ile Thr Leu Ala Asn Lys His Leu Ala Ile
        195                 200                 205             
Gly Leu Val His Asn Gly Gln Tyr Arg Ile Lys Thr Phe Asp Ala Asn
    210                 215                 220                 
Thr Gly Asn His Asp Val Ala Ser Gly Ser Thr Val Ile Tyr Leu Gln
225                 230                 235                 240 
Pro Glu Asp Glu Val Trp Leu Glu Ile Phe Phe Thr Asp Gln Asn Gly
                245                 250                 255     
Leu Phe Ser Asp Pro Gly Trp Ala Asp Ser Leu Phe Ser Gly Phe Leu
            260                 265                 270         
Leu Tyr Val Asp Thr Asp Tyr Leu Asp Ser Ile Ser Glu Asp Asp Glu
        275                 280                 285             
Leu
    


<210> 1763
<211> 556
<212> PRT
<213> Homo sapiens

<400> 1763
Met Val Tyr Arg Leu Pro Val Phe Lys Arg Tyr Met Gly Asn Thr Pro
 1               5                  10                  15      
Gln Lys Lys Ala Val Phe Gly Gln Cys Arg Gly Leu Pro Cys Val Ala
            20                  25                  30          
Pro Leu Leu Thr Thr Val Glu Glu Ala Pro Arg Gly Ile Ser Ala Arg
        35                  40                  45              
Val Trp Gly His Phe Pro Lys Trp Leu Asn Gly Ser Leu Leu Arg Ile
    50                  55                  60                  
Gly Pro Gly Lys Phe Glu Phe Gly Lys Asp Lys Tyr Asn His Trp Phe
65                  70                  75                  80  
Asp Gly Met Ala Leu Leu His Gln Phe Arg Met Ala Lys Gly Thr Val
                85                  90                  95      
Thr Tyr Arg Ser Lys Phe Leu Gln Ser Asp Thr Tyr Lys Ala Asn Ser
            100                 105                 110         
Ala Lys Asn Arg Ile Val Ile Ser Glu Phe Gly Thr Leu Ala Leu Pro
        115                 120                 125             
Asp Pro Cys Lys Asn Val Phe Glu Arg Phe Met Ser Arg Phe Glu Leu
    130                 135                 140                 
Pro Gly Lys Ala Ala Ala Met Thr Asp Asp Thr Asn Val Asn Tyr Val
145                 150                 155                 160 
Arg Tyr Lys Gly Asp Tyr Tyr Leu Cys Thr Glu Thr Asn Phe Met Asn
                165                 170                 175     
Lys Val Asp Ile Glu Thr Leu Glu Lys Thr Glu Lys Val Asp Trp Ser
            180                 185                 190         
Lys Phe Ile Ala Val Asn Gly Ala Thr Ala His Pro His Tyr Asp Pro
        195                 200                 205             
Asp Gly Thr Ala Tyr Asn Met Gly Asn Ser Phe Gly Pro Tyr Gly Phe
    210                 215                 220                 
Ser Tyr Lys Val Ile Arg Val Pro Pro Glu Glu Val Asp Leu Gly Glu
225                 230                 235                 240 
Thr Ile His Gly Val Gln Val Ile Cys Ser Ile Ala Ser Thr Glu Lys
                245                 250                 255     
Gly Lys Pro Ser Tyr Tyr His Ser Phe Gly Met Thr Arg Asn Tyr Ile
            260                 265                 270         
Ile Phe Ile Glu Gln Pro Leu Lys Met Asn Leu Trp Lys Ile Ala Thr
        275                 280                 285             
Ser Lys Ile Arg Gly Lys Ala Phe Ser Asp Gly Ile Ser Trp Glu Pro
    290                 295                 300                 
Gln Cys Asn Thr Arg Phe His Val Val Glu Lys Arg Thr Gly Gln Leu
305                 310                 315                 320 
Leu Pro Gly Arg Tyr Tyr Ser Lys Pro Phe Val Thr Phe His Gln Ile
                325                 330                 335     
Asn Ala Phe Glu Asp Gln Gly Cys Val Ile Ile Asp Leu Cys Cys Gln
            340                 345                 350         
Asp Asn Gly Arg Thr Leu Glu Val Tyr Gln Leu Gln Asn Leu Arg Lys
        355                 360                 365             
Ala Gly Glu Gly Leu Asp Gln Val His Asn Ser Ala Ala Lys Ser Phe
    370                 375                 380                 
Pro Arg Arg Phe Val Leu Pro Leu Asn Val Ser Leu Asn Ala Pro Glu
385                 390                 395                 400 
Gly Asp Asn Leu Ser Pro Leu Ser Tyr Thr Ser Ala Ser Ala Val Lys
                405                 410                 415     
Gln Ala Asp Gly Thr Ile Cys Cys Ser His Glu Asn Leu His Gln Glu
            420                 425                 430         
Asp Leu Glu Lys Glu Gly Gly Ile Glu Phe Pro Gln Ile Tyr Tyr Asp
        435                 440                 445             
Arg Phe Ser Gly Lys Lys Tyr His Phe Phe Tyr Gly Cys Gly Phe Arg
    450                 455                 460                 
His Leu Val Gly Asp Ser Leu Ile Lys Val Asp Val Val Asn Lys Thr
465                 470                 475                 480 
Leu Lys Val Trp Arg Glu Asp Gly Phe Tyr Pro Ser Glu Pro Val Phe
                485                 490                 495     
Val Pro Ala Pro Gly Thr Asn Glu Glu Asp Gly Gly Val Ile Leu Ser
            500                 505                 510         
Val Val Ile Thr Pro Asn Gln Asn Glu Ser Asn Phe Leu Leu Val Leu
        515                 520                 525             
Asp Ala Lys Asn Phe Glu Glu Leu Gly Arg Ala Glu Val Pro Val Gln
    530                 535                 540                 
Met Pro Tyr Gly Phe His Gly Thr Phe Ile Pro Ile
545                 550                 555     


<210> 1764
<211> 1560
<212> PRT
<213> Homo sapiens

<400> 1764
Pro Val Cys Cys Ala Gly Ser Phe Arg Leu Asp Pro Val Gly Tyr Thr
 1               5                  10                  15      
Ala Ser Ala Leu Gly Ile Thr His Pro Cys Ala Leu Ala Arg Met Lys
            20                  25                  30          
Glu Ala Ser Gly Val Gly Gly Gly His Ser Pro Met Cys Pro Pro His
        35                  40                  45              
Cys His Met Pro Pro Gly Pro Ala Gly Glu Trp Pro Gly Ala Thr Val
    50                  55                  60                  
Gln Gln Pro Arg Gln Arg Ala Pro Thr Ala Leu Leu Gln Pro Asp Ala
65                  70                  75                  80  
Ala Gly Pro Gly Gly Gly Gly Val Ser Ala Gly Val Ala Val Leu Gly
                85                  90                  95      
Ala Cys Pro Ser Ala Ser Glu Gly Val Leu Pro Arg Pro Pro Gly Arg
            100                 105                 110         
Ser Ala Pro Gln Pro Pro Glu Tyr Pro Gly Arg Pro Asp Met Ala Val
        115                 120                 125             
Pro Gly Trp Ser Ala Met Val Arg Ser Arg Leu Thr Ala Thr Ser Thr
    130                 135                 140                 
Ser Gln Ala Thr Asp His Thr Phe Leu Gln Lys Ser His Tyr His His
145                 150                 155                 160 
Gly Asp His Pro Ser Tyr Ala Lys Pro Arg Leu Pro Leu Pro Val Phe
                165                 170                 175     
Thr Val Arg His Tyr Ala Gly Thr Val Thr Tyr Gln Val His Lys Phe
            180                 185                 190         
Leu Asn Arg Asn Arg Asp Gln Leu Asp Pro Ala Val Val Glu Met Leu
        195                 200                 205             
Gly Gln Ser Gln Leu Gln Leu Val Gly Ser Leu Phe Gln Glu Ala Glu
    210                 215                 220                 
Pro Gln Ser Arg Gly Gly Arg Gly Arg Pro Thr Leu Ala Ser Arg Phe
225                 230                 235                 240 
Gln Gln Ala Leu Glu Asp Leu Ile Ala Arg Leu Gly Arg Ser His Val
                245                 250                 255     
Tyr Phe Ile Gln Cys Leu Thr Pro Asn Pro Gly Lys Leu Pro Gly Leu
            260                 265                 270         
Phe Asp Val Gly His Val Thr Glu Gln Leu His Gln Ala Ala Ile Leu
        275                 280                 285             
Glu Ala Val Gly Thr Arg Ser Ala Asn Phe Pro Val Arg Val Pro Phe
    290                 295                 300                 
Glu Ala Phe Leu Ala Ser Phe Gln Ala Leu Gly Ser Glu Gly Gln Glu
305                 310                 315                 320 
Asp Leu Ser Asp Arg Glu Lys Cys Gly Ala Val Leu Ser Gln Val Leu
                325                 330                 335     
Gly Ala Glu Ser Pro Leu Tyr His Leu Gly Ala Thr Lys Val Leu Leu
            340                 345                 350         
Gln Glu Gln Gly Trp Gln Arg Leu Glu Glu Leu Arg Asp Gln Gln Arg
        355                 360                 365             
Ser Gln Ala Leu Val Asp Leu His Arg Ser Phe His Thr Cys Ile Ser
    370                 375                 380                 
Arg Gln Arg Val Leu Pro Arg Met Gln Ala Arg Met Arg Gly Phe Gln
385                 390                 395                 400 
Ala Arg Lys Arg Tyr Leu Arg Arg Arg Ala Ala Leu Gly Gln Leu Asn
                405                 410                 415     
Thr Ile Leu Leu Val Ala Gln Pro Leu Leu Gln Arg Arg Gln Arg Leu
            420                 425                 430         
Gln Leu Gly Arg Trp Gln Gly Trp His Ser Ser Glu Arg Ala Leu Glu
        435                 440                 445             
Arg Val Pro Ser Met Glu Leu Gly Arg Leu Glu Ile Pro Ala Glu Leu
    450                 455                 460                 
Ala Val Met Leu Lys Thr Ala Glu Ser His Arg Asp Ala Leu Ala Gly
465                 470                 475                 480 
Ser Ile Thr Glu Cys Leu Pro Pro Glu Val Pro Ala Arg Pro Ser Leu
                485                 490                 495     
Thr Leu Pro Ala Asp Ile Asp Leu Phe Pro Phe Ser Ser Phe Val Ala
            500                 505                 510         
Ile Gly Phe Gln Glu Pro Ser Leu Pro Arg Pro Gly Gln Pro Leu Ala
        515                 520                 525             
Lys Pro Leu Thr Gln Leu Asp Gly Asp Asn Pro Gln Arg Ala Leu Asp
    530                 535                 540                 
Ile Asn Lys Val Met Leu Arg Leu Leu Gly Asp Gly Ser Leu Glu Ser
545                 550                 555                 560 
Trp Gln Arg Gln Ile Met Gly Ala Tyr Leu Val Arg Gln Gly Gln Cys
                565                 570                 575     
Trp Pro Gly Leu Arg Asn Glu Leu Phe Ser Gln Leu Val Ala Gln Leu
            580                 585                 590         
Trp Gln Asn Pro Asp Glu Gln Gln Ser Gln Arg Gly Trp Ala Leu Met
        595                 600                 605             
Ala Val Leu Leu Ser Ala Phe Pro Pro Leu Pro Val Leu Gln Lys Pro
    610                 615                 620                 
Leu Leu Lys Phe Val Ser Asp Gln Ala Pro Arg Gly Met Ala Ala Leu
625                 630                 635                 640 
Cys Gln His Lys Leu Leu Gly Ala Leu Glu Gln Ser Gln Leu Ala Ser
                645                 650                 655     
Gly Ala Thr Arg Ala His Pro Pro Thr Gln Leu Glu Trp Leu Ala Gly
            660                 665                 670         
Trp Arg Arg Gly Arg Met Ala Leu Asp Val Phe Thr Phe Ser Glu Glu
        675                 680                 685             
Cys Tyr Ser Ala Glu Val Glu Ser Trp Thr Thr Gly Glu Gln Leu Ala
    690                 695                 700                 
Gly Trp Ile Leu Gln Ser Arg Gly Leu Glu Ala Pro Pro Arg Gly Trp
705                 710                 715                 720 
Ser Val Ser Leu His Ser Arg Asp Ala Trp Gln Asp Leu Ala Gly Cys
                725                 730                 735     
Asp Phe Val Leu Asp Leu Ile Ser Gln Thr Glu Asp Leu Gly Asp Pro
            740                 745                 750         
Ala Arg Pro Arg Ser Tyr Pro Ile Thr Pro Leu Gly Ser Ala Glu Ala
        755                 760                 765             
Ile Pro Leu Ala Pro Gly Ile Gln Ala Pro Ser Leu Pro Pro Gly Pro
    770                 775                 780                 
Pro Pro Gly Pro Ala Pro Thr Leu Pro Ser Arg Asp His Thr Gly Glu
785                 790                 795                 800 
Val Gln Arg Ser Gly Ser Leu Asp Gly Phe Leu Asp Gln Ile Phe Gln
                805                 810                 815     
Pro Val Ile Ser Ser Gly Leu Ser Asp Leu Glu Gln Ser Trp Ala Leu
            820                 825                 830         
Ser Ser Arg Met Lys Gly Gly Gly Ala Ile Gly Pro Thr Gln Gln Gly
        835                 840                 845             
Tyr Pro Met Val Tyr Pro Gly Met Ile Gln Met Pro Ala Tyr Gln Pro
    850                 855                 860                 
Gly Met Val Pro Ala Pro Met Pro Met Met Pro Ala Met Gly Thr Val
865                 870                 875                 880 
Pro Ala Met Pro Ala Met Val Val Pro Pro Gln Pro Pro Leu Pro Ser
                885                 890                 895     
Leu Asp Ala Gly Gln Leu Ala Val Gln Gln Gln Asn Phe Ile Gln Gln
            900                 905                 910         
Gln Ala Leu Ile Leu Ala Gln Gln Met Thr Ala Gln Ala Met Ser Leu
        915                 920                 925             
Ser Leu Glu Gln Gln Met Gln Gln Arg Gln Gln Gln Ala Arg Ala Ser
    930                 935                 940                 
Glu Ala Ala Ser Gln Ala Ser Pro Ser Ala Val Thr Ser Lys Pro Arg
945                 950                 955                 960 
Lys Pro Pro Thr Pro Pro Glu Lys Pro Gln Arg Asp Leu Gly Ser Glu
                965                 970                 975     
Gly Gly Cys Leu Arg Glu Thr Ser Glu Glu Ala Glu Asp Arg Pro Tyr
            980                 985                 990         
Gln Pro Lys Ser Phe Gln Gln Lys Arg Asn Tyr Phe Gln Arg Met Gly
        995                 1000                1005            
Gln Pro Gln Ile Thr Val Arg Thr Met Lys Pro Pro Ala Lys Val His
    1010                1015                1020                
Ile Pro Gln Gly Glu Ala Gln Glu Glu Glu Glu Glu Glu Glu Glu Glu
1025                1030                1035                1040
Glu Glu Gln Glu Glu Gln Glu Val Glu Thr Arg Ala Val Pro Ser Pro
                1045                1050                1055    
Pro Pro Pro Pro Ile Val Lys Lys Pro Leu Lys Gln Gly Gly Ala Lys
            1060                1065                1070        
Ala Pro Lys Glu Ala Glu Ala Glu Pro Ala Lys Glu Thr Ala Ala Lys
        1075                1080                1085            
Gly His Gly Gln Gly Pro Ala Gln Gly Arg Gly Thr Val Val Arg Ser
    1090                1095                1100                
Ser Asp Ser Lys Pro Lys Arg Pro Gln Pro Ser Arg Glu Ile Gly Asn
1105                1110                1115                1120
Ile Ile Arg Met Tyr Gln Ser Arg Pro Gly Pro Val Pro Val Pro Val
                1125                1130                1135    
Gln Pro Ser Arg Pro Pro Lys Ala Phe Leu Arg Lys Ile Asp Pro Lys
            1140                1145                1150        
Asp Glu Ala Leu Ala Lys Leu Gly Ile Asn Gly Ala His Ser Ser Pro
        1155                1160                1165            
Pro Met Leu Ser Pro Ser Pro Gly Lys Gly Pro Pro Pro Ala Val Ala
    1170                1175                1180                
Pro Arg Pro Lys Ala Pro Leu Gln Leu Gly Pro Ser Ser Ser Ile Lys
1185                1190                1195                1200
Glu Lys Gln Gly Pro Leu Leu Asp Leu Phe Gly Gln Lys Leu Pro Ile
                1205                1210                1215    
Ala His Thr Pro Pro Pro Pro Pro Ala Pro Pro Leu Pro Leu Pro Glu
            1220                1225                1230        
Asp Pro Gly Thr Leu Ser Ala Glu Arg Arg Cys Leu Thr Gln Pro Val
        1235                1240                1245            
Glu Asp Gln Gly Val Ser Thr Gln Leu Leu Ala Pro Ser Gly Ser Val
    1250                1255                1260                
Cys Phe Ser Tyr Thr Gly Thr Pro Trp Lys Leu Phe Leu Arg Lys Glu
1265                1270                1275                1280
Val Phe Tyr Pro Arg Glu Asn Phe Ser His Pro Tyr Tyr Leu Arg Leu
                1285                1290                1295    
Leu Cys Glu Gln Ile Leu Arg Asp Thr Phe Ser Glu Ser Cys Ile Arg
            1300                1305                1310        
Ile Ser Gln Asn Glu Arg Arg Lys Met Lys Asp Leu Leu Gly Gly Leu
        1315                1320                1325            
Glu Val Asp Leu Asp Ser Leu Thr Thr Thr Glu Asp Ser Val Lys Lys
    1330                1335                1340                
Arg Ile Val Val Ala Ala Arg Asp Asn Trp Ala Asn Tyr Phe Ser Arg
1345                1350                1355                1360
Phe Phe Pro Val Ser Gly Glu Ser Gly Ser Asp Val Gln Leu Leu Ala
                1365                1370                1375    
Val Ser His Arg Gly Leu Arg Leu Leu Lys Val Thr Gln Gly Pro Gly
            1380                1385                1390        
Leu Arg Pro Asp Gln Leu Lys Ile Leu Cys Ser Tyr Ser Phe Ala Glu
        1395                1400                1405            
Val Leu Gly Val Glu Cys Arg Gly Gly Ser Thr Leu Glu Leu Ser Leu
    1410                1415                1420                
Lys Ser Glu Gln Leu Val Leu His Thr Ala Arg Ala Arg Ala Ile Glu
1425                1430                1435                1440
Ala Leu Val Glu Leu Phe Leu Asn Glu Leu Lys Lys Asp Ser Gly Tyr
                1445                1450                1455    
Val Ile Ala Leu Arg Ser Tyr Ile Thr Asp Asn Cys Ser Leu Leu Ser
            1460                1465                1470        
Phe His Arg Gly Asp Leu Ile Lys Leu Leu Pro Val Ala Thr Leu Glu
        1475                1480                1485            
Pro Gly Trp Gln Phe Gly Ser Ala Gly Gly Arg Ser Gly Leu Phe Pro
    1490                1495                1500                
Ala Asp Ile Val Gln Pro Ala Ala Ala Pro Asp Phe Ser Phe Ser Lys
1505                1510                1515                1520
Glu Gln Arg Ser Gly Trp His Lys Gly Gln Leu Ser Asn Gly Glu Pro
                1525                1530                1535    
Gly Leu Ala Arg Trp Asp Arg Ala Ser Glu Val Arg Lys Met Gly Glu
            1540                1545                1550        
Gly Gln Ala Glu Ala Arg Pro Ala
        1555                1560


<210> 1765
<211> 1560
<212> PRT
<213> Homo sapiens

<400> 1765
Pro Val Cys Cys Ala Gly Ser Phe Arg Leu Asp Pro Val Gly Tyr Thr
 1               5                  10                  15      
Ala Ser Ala Leu Gly Ile Thr His Pro Cys Ala Leu Ala Arg Met Lys
            20                  25                  30          
Glu Ala Ser Gly Val Gly Gly Gly His Ser Pro Met Cys Pro Pro His
        35                  40                  45              
Cys His Met Pro Pro Gly Pro Ala Gly Glu Trp Pro Gly Ala Thr Val
    50                  55                  60                  
Gln Gln Pro Arg Gln Arg Ala Pro Thr Ala Leu Leu Gln Pro Asp Ala
65                  70                  75                  80  
Ala Gly Pro Gly Gly Gly Gly Val Ser Ala Gly Val Ala Val Leu Gly
                85                  90                  95      
Ala Cys Pro Ser Ala Ser Glu Gly Val Leu Pro Arg Pro Pro Gly Arg
            100                 105                 110         
Ser Ala Pro Gln Pro Pro Glu Tyr Pro Gly Arg Pro Asp Met Ala Val
        115                 120                 125             
Pro Gly Trp Ser Ala Met Val Arg Ser Arg Leu Thr Ala Thr Ser Thr
    130                 135                 140                 
Ser Gln Ala Thr Asp His Thr Phe Leu Gln Lys Ser His Tyr His His
145                 150                 155                 160 
Gly Asp His Pro Ser Tyr Ala Lys Pro Arg Leu Pro Leu Pro Val Phe
                165                 170                 175     
Thr Val Arg His Tyr Ala Gly Thr Val Thr Tyr Gln Val His Lys Phe
            180                 185                 190         
Leu Asn Arg Asn Arg Asp Gln Leu Asp Pro Ala Val Val Glu Met Leu
        195                 200                 205             
Gly Gln Ser Gln Leu Gln Leu Val Gly Ser Leu Phe Gln Glu Ala Glu
    210                 215                 220                 
Pro Gln Ser Arg Gly Gly Arg Gly Arg Pro Thr Leu Ala Ser Arg Phe
225                 230                 235                 240 
Gln Gln Ala Leu Glu Asp Leu Ile Ala Arg Leu Gly Arg Ser His Val
                245                 250                 255     
Tyr Phe Ile Gln Cys Leu Thr Pro Asn Pro Gly Lys Leu Pro Gly Leu
            260                 265                 270         
Phe Asp Val Gly His Val Thr Glu Gln Leu His Gln Ala Ala Ile Leu
        275                 280                 285             
Glu Ala Val Gly Thr Arg Ser Ala Asn Phe Pro Val Arg Val Pro Phe
    290                 295                 300                 
Glu Ala Phe Leu Ala Ser Phe Gln Ala Leu Gly Ser Glu Gly Gln Glu
305                 310                 315                 320 
Asp Leu Ser Asp Arg Glu Lys Cys Gly Ala Val Leu Ser Gln Val Leu
                325                 330                 335     
Gly Ala Glu Ser Pro Leu Tyr His Leu Gly Ala Thr Lys Val Leu Leu
            340                 345                 350         
Gln Glu Gln Gly Trp Gln Arg Leu Glu Glu Leu Arg Asp Gln Gln Arg
        355                 360                 365             
Ser Gln Ala Leu Val Asp Leu His Arg Ser Phe His Thr Cys Ile Ser
    370                 375                 380                 
Arg Gln Arg Val Leu Pro Arg Met Gln Ala Arg Met Arg Gly Phe Gln
385                 390                 395                 400 
Ala Arg Lys Arg Tyr Leu Arg Arg Arg Ala Ala Leu Gly Gln Leu Asn
                405                 410                 415     
Thr Ile Leu Leu Val Ala Gln Pro Leu Leu Gln Arg Arg Gln Arg Leu
            420                 425                 430         
Gln Leu Gly Arg Trp Gln Gly Trp His Ser Ser Glu Arg Ala Leu Glu
        435                 440                 445             
Arg Val Pro Ser Met Glu Leu Gly Arg Leu Glu Ile Pro Ala Glu Leu
    450                 455                 460                 
Ala Val Met Leu Lys Thr Ala Glu Ser His Arg Asp Ala Leu Ala Gly
465                 470                 475                 480 
Ser Ile Thr Glu Cys Leu Pro Pro Glu Val Pro Ala Arg Pro Ser Leu
                485                 490                 495     
Thr Leu Pro Ala Asp Ile Asp Leu Phe Pro Phe Ser Ser Phe Val Ala
            500                 505                 510         
Ile Gly Phe Gln Glu Pro Ser Leu Pro Arg Pro Gly Gln Pro Leu Ala
        515                 520                 525             
Lys Pro Leu Thr Gln Leu Asp Gly Asp Asn Pro Gln Arg Ala Leu Asp
    530                 535                 540                 
Ile Asn Lys Val Met Leu Arg Leu Leu Gly Asp Gly Ser Leu Glu Ser
545                 550                 555                 560 
Trp Gln Arg Gln Ile Met Gly Ala Tyr Leu Val Arg Gln Gly Gln Cys
                565                 570                 575     
Trp Pro Gly Leu Arg Asn Glu Leu Phe Ser Gln Leu Val Ala Gln Leu
            580                 585                 590         
Trp Gln Asn Pro Asp Glu Gln Gln Ser Gln Arg Gly Trp Ala Leu Met
        595                 600                 605             
Ala Val Leu Leu Ser Ala Phe Pro Pro Leu Pro Val Leu Gln Lys Pro
    610                 615                 620                 
Leu Leu Lys Phe Val Ser Asp Gln Ala Pro Arg Gly Met Ala Ala Leu
625                 630                 635                 640 
Cys Gln His Lys Leu Leu Gly Ala Leu Glu Gln Ser Gln Leu Ala Ser
                645                 650                 655     
Gly Ala Thr Arg Ala His Pro Pro Thr Gln Leu Glu Trp Leu Ala Gly
            660                 665                 670         
Trp Arg Arg Gly Arg Met Ala Leu Asp Val Phe Thr Phe Ser Glu Glu
        675                 680                 685             
Cys Tyr Ser Ala Glu Val Glu Ser Trp Thr Thr Gly Glu Gln Leu Ala
    690                 695                 700                 
Gly Trp Ile Leu Gln Ser Arg Gly Leu Glu Ala Pro Pro Arg Gly Trp
705                 710                 715                 720 
Ser Val Ser Leu His Ser Arg Asp Ala Trp Gln Asp Leu Ala Gly Cys
                725                 730                 735     
Asp Phe Val Leu Asp Leu Ile Ser Gln Thr Glu Asp Leu Gly Asp Pro
            740                 745                 750         
Ala Arg Pro Arg Ser Tyr Pro Ile Thr Pro Leu Gly Ser Ala Glu Ala
        755                 760                 765             
Ile Pro Leu Ala Pro Gly Ile Gln Ala Pro Ser Leu Pro Pro Gly Pro
    770                 775                 780                 
Pro Pro Gly Pro Ala Pro Thr Leu Pro Ser Arg Asp His Thr Gly Glu
785                 790                 795                 800 
Val Gln Arg Ser Gly Ser Leu Asp Gly Phe Leu Asp Gln Ile Phe Gln
                805                 810                 815     
Pro Val Ile Ser Ser Gly Leu Ser Asp Leu Glu Gln Ser Trp Ala Leu
            820                 825                 830         
Ser Ser Arg Met Lys Gly Gly Gly Ala Ile Gly Pro Thr Gln Gln Gly
        835                 840                 845             
Tyr Pro Met Val Tyr Pro Gly Met Ile Gln Met Pro Ala Tyr Gln Pro
    850                 855                 860                 
Gly Met Val Pro Ala Pro Met Pro Met Met Pro Ala Met Gly Thr Val
865                 870                 875                 880 
Pro Ala Met Pro Ala Met Val Val Pro Pro Gln Pro Pro Leu Pro Ser
                885                 890                 895     
Leu Asp Ala Gly Gln Leu Ala Val Gln Gln Gln Asn Phe Ile Gln Gln
            900                 905                 910         
Gln Ala Leu Ile Leu Ala Gln Gln Met Thr Ala Gln Ala Met Ser Leu
        915                 920                 925             
Ser Leu Glu Gln Gln Met Gln Gln Arg Gln Gln Gln Ala Arg Ala Ser
    930                 935                 940                 
Glu Ala Ala Ser Gln Ala Ser Pro Ser Ala Val Thr Ser Lys Pro Arg
945                 950                 955                 960 
Lys Pro Pro Thr Pro Pro Glu Lys Pro Gln Arg Asp Leu Gly Ser Glu
                965                 970                 975     
Gly Gly Cys Leu Arg Glu Thr Ser Glu Glu Ala Glu Asp Arg Pro Tyr
            980                 985                 990         
Gln Pro Lys Ser Phe Gln Gln Lys Arg Asn Tyr Phe Gln Arg Met Gly
        995                 1000                1005            
Gln Pro Gln Ile Thr Val Arg Thr Met Lys Pro Pro Ala Lys Val His
    1010                1015                1020                
Ile Pro Gln Gly Glu Ala Gln Glu Glu Glu Glu Glu Glu Glu Glu Glu
1025                1030                1035                1040
Glu Glu Gln Glu Glu Gln Glu Val Glu Thr Arg Ala Val Pro Ser Pro
                1045                1050                1055    
Pro Pro Pro Pro Ile Val Lys Lys Pro Leu Lys Gln Gly Gly Ala Lys
            1060                1065                1070        
Ala Pro Lys Glu Ala Glu Ala Glu Pro Ala Lys Glu Thr Ala Ala Lys
        1075                1080                1085            
Gly His Gly Gln Gly Pro Ala Gln Gly Arg Gly Thr Val Val Arg Ser
    1090                1095                1100                
Ser Asp Ser Lys Pro Lys Arg Pro Gln Pro Ser Arg Glu Ile Gly Asn
1105                1110                1115                1120
Ile Ile Arg Met Tyr Gln Ser Arg Pro Gly Pro Val Pro Val Pro Val
                1125                1130                1135    
Gln Pro Ser Arg Pro Pro Lys Ala Phe Leu Arg Lys Ile Asp Pro Lys
            1140                1145                1150        
Asp Glu Ala Leu Ala Lys Leu Gly Ile Asn Gly Ala His Ser Ser Pro
        1155                1160                1165            
Pro Met Leu Ser Pro Ser Pro Gly Lys Gly Pro Pro Pro Ala Val Ala
    1170                1175                1180                
Pro Arg Pro Lys Ala Pro Leu Gln Leu Gly Pro Ser Ser Ser Ile Lys
1185                1190                1195                1200
Glu Lys Gln Gly Pro Leu Leu Asp Leu Phe Gly Gln Lys Leu Pro Ile
                1205                1210                1215    
Ala His Thr Pro Pro Pro Pro Pro Ala Pro Pro Leu Pro Leu Pro Glu
            1220                1225                1230        
Asp Pro Gly Thr Leu Ser Ala Glu Arg Arg Cys Leu Thr Gln Pro Val
        1235                1240                1245            
Glu Asp Gln Gly Val Ser Thr Gln Leu Leu Ala Pro Ser Gly Ser Val
    1250                1255                1260                
Cys Phe Ser Tyr Thr Gly Thr Pro Trp Lys Leu Phe Leu Arg Lys Glu
1265                1270                1275                1280
Val Phe Tyr Pro Arg Glu Asn Phe Ser His Pro Tyr Tyr Leu Arg Leu
                1285                1290                1295    
Leu Cys Glu Gln Ile Leu Arg Asp Thr Phe Ser Glu Ser Cys Ile Arg
            1300                1305                1310        
Ile Ser Gln Asn Glu Arg Arg Lys Met Lys Asp Leu Leu Gly Gly Leu
        1315                1320                1325            
Glu Val Asp Leu Asp Ser Leu Thr Thr Thr Glu Asp Ser Val Lys Lys
    1330                1335                1340                
Arg Ile Val Val Ala Ala Arg Asp Asn Trp Ala Asn Tyr Phe Ser Arg
1345                1350                1355                1360
Phe Phe Pro Val Ser Gly Glu Ser Gly Ser Asp Val Gln Leu Leu Ala
                1365                1370                1375    
Val Ser His Arg Gly Leu Arg Leu Leu Lys Val Thr Gln Gly Pro Gly
            1380                1385                1390        
Leu Arg Pro Asp Gln Leu Lys Ile Leu Cys Ser Tyr Ser Phe Ala Glu
        1395                1400                1405            
Val Leu Gly Val Glu Cys Arg Gly Gly Ser Thr Leu Glu Leu Ser Leu
    1410                1415                1420                
Lys Ser Glu Gln Leu Val Leu His Thr Ala Arg Ala Arg Ala Ile Glu
1425                1430                1435                1440
Ala Leu Val Glu Leu Phe Leu Asn Glu Leu Lys Lys Asp Ser Gly Tyr
                1445                1450                1455    
Val Ile Ala Leu Arg Ser Tyr Ile Thr Asp Asn Cys Ser Leu Leu Ser
            1460                1465                1470        
Phe His Arg Gly Asp Leu Ile Lys Leu Leu Pro Val Ala Thr Leu Glu
        1475                1480                1485            
Pro Gly Trp Gln Phe Gly Ser Ala Gly Gly Arg Ser Gly Leu Phe Pro
    1490                1495                1500                
Ala Asp Ile Val Gln Pro Ala Ala Ala Pro Asp Phe Ser Phe Ser Lys
1505                1510                1515                1520
Glu Gln Arg Ser Gly Trp His Lys Gly Gln Leu Ser Asn Gly Glu Pro
                1525                1530                1535    
Gly Leu Ala Arg Trp Asp Arg Ala Ser Glu Val Arg Lys Met Gly Glu
            1540                1545                1550        
Gly Gln Ala Glu Ala Arg Pro Ala
        1555                1560


<210> 1766
<211> 572
<212> PRT
<213> Homo sapiens

<400> 1766
Ser Ser Thr His Gly Ser Arg Phe Pro Leu Cys Gly Gly Arg Arg Asp
 1               5                  10                  15      
His Lys Gly Leu Thr His Ile Phe Asn Pro Pro Pro Lys Arg Phe Glu
            20                  25                  30          
Ser Ile Leu Glu Gly Leu Phe Gly Pro Ala Leu Leu Lys Asp Leu Ser
        35                  40                  45              
Leu Phe Lys Asp Cys Glu Pro Glu Ser Ile Ser Asp Trp Thr Phe Asp
    50                  55                  60                  
Glu Asn Cys Leu Phe Cys Cys Leu Arg Arg Asp Lys Val Lys Gly His
65                  70                  75                  80  
Leu Val Gly Leu Asp Glu Pro Ala Ser Gly Ala Gly Gln Glu Ala Leu
                85                  90                  95      
Leu Lys Gln Glu Gln Ala Lys Ile Ile Arg Phe Glu Arg Gln Ala Glu
            100                 105                 110         
Glu Phe Leu Asn Ala Val Phe Tyr Arg Lys Asp Ser Pro Trp Val Ser
        115                 120                 125             
Asp Pro Asn Ile Pro Leu Val Ala Arg Glu Ile Met Gln Arg Met Ile
    130                 135                 140                 
Gln Gln Phe Ala Ala Glu Tyr Thr Ser Lys Asn Ser Ser Thr Gln Asp
145                 150                 155                 160 
Pro Ser Gln Pro Asn Ser Thr Lys Asn Gln Ser Leu Pro Lys Ala Ser
                165                 170                 175     
Pro Val Thr Thr Ser Pro Thr Ala Ala Thr Thr Gln Asn Pro Val Leu
            180                 185                 190         
Ser Lys Leu Leu Met Ala Asp Gln Asp Ser Pro Leu Asp Leu Thr Val
        195                 200                 205             
Arg Lys Ser Gln Ser Glu Pro Ser Glu Gln Asp Gly Val Leu Asp Leu
    210                 215                 220                 
Ser Thr Lys Lys Ser Pro Cys Ala Gly Ser Thr Ser Leu Ser His Ser
225                 230                 235                 240 
Pro Gly Cys Ser Ser Thr Gln Gly Asn Gly Arg Pro Gly Arg Pro Ser
                245                 250                 255     
Gln Tyr Arg Pro Asp Gly Leu Arg Ser Gly Asp Gly Val Pro Pro Arg
            260                 265                 270         
Ser Leu Gln Asp Gly Thr Arg Glu Gly Phe Gly His Ser Thr Ser Leu
        275                 280                 285             
Lys Val Pro Leu Ala Arg Ser Leu Gln Ile Ser Glu Glu Leu Leu Ser
    290                 295                 300                 
Arg Asn Gln Leu Ser Thr Ala Ala Ser Leu Gly Pro Ser Gly Leu Gln
305                 310                 315                 320 
Asn His Gly Gln His Leu Ile Leu Ser Arg Glu Ala Ser Trp Ala Lys
                325                 330                 335     
Pro His Tyr Glu Phe Asn Leu Ser Arg Met Lys Phe Arg Gly Asn Gly
            340                 345                 350         
Ala Leu Ser Asn Ile Ser Asp Leu Pro Phe Leu Ala Glu Asn Ser Ala
        355                 360                 365             
Phe Pro Lys Met Ala Leu Gln Ala Lys Gln Asp Gly Lys Lys Asp Val
    370                 375                 380                 
Ser His Ser Ser Pro Val Asp Leu Lys Ile Pro Gln Val Arg Gly Met
385                 390                 395                 400 
Asp Leu Ser Trp Glu Ser Arg Thr Gly Asp Gln Tyr Ser Tyr Ser Ser
                405                 410                 415     
Leu Val Met Gly Ser Gln Thr Glu Ser Ala Leu Ser Lys Lys Leu Arg
            420                 425                 430         
Ala Ile Leu Pro Lys Gln Ser Arg Lys Ser Met Leu Asp Ala Gly Pro
        435                 440                 445             
Asp Ser Trp Gly Ser Asp Ala Glu Gln Ser Thr Ser Gly Gln Pro Tyr
    450                 455                 460                 
Pro Thr Ser Asp Gln Glu Gly Asp Pro Gly Ser Lys Gln Pro Arg Lys
465                 470                 475                 480 
Lys Arg Gly Arg Tyr Arg Gln Tyr Asn Ser Glu Ile Leu Glu Glu Ala
                485                 490                 495     
Ile Ser Val Val Met Ser Gly Lys Met Ser Val Ser Lys Ala Gln Ser
            500                 505                 510         
Ile Tyr Gly Ile Pro His Ser Thr Leu Glu Tyr Lys Val Lys Glu Arg
        515                 520                 525             
Leu Gly Thr Leu Lys Asn Pro Pro Lys Lys Lys Met Lys Leu Met Arg
    530                 535                 540                 
Ser Glu Gly Pro Asp Val Ser Val Lys Ile Glu Leu Asp Pro Gln Gly
545                 550                 555                 560 
Glu Ala Ala Gln Ser Ala Asn Glu Ser Lys Asn Glu
                565                 570         


<210> 1767
<211> 539
<212> PRT
<213> Homo sapiens

<400> 1767
Glu Val Leu Arg Val Gln Asp Lys Tyr Phe His Ile Lys Cys Phe Val
 1               5                  10                  15      
Cys Lys Ala Cys Gly Cys Asp Leu Ala Glu Gly Gly Phe Phe Val Arg
            20                  25                  30          
Gln Gly Glu Tyr Ile Cys Thr Leu Asp Tyr Gln Arg Leu Tyr Gly Thr
        35                  40                  45              
Arg Cys Phe Ser Cys Asp Gln Phe Ile Glu Gly Glu Val Val Ser Ala
    50                  55                  60                  
Leu Gly Lys Thr Tyr His Pro Asp Cys Phe Val Cys Ala Val Cys Arg
65                  70                  75                  80  
Leu Pro Phe Pro Pro Gly Asp Arg Val Thr Phe Asn Gly Lys Glu Cys
                85                  90                  95      
Met Cys Gln Lys Cys Ser Leu Pro Val Ser Val Gly Ser Ser Ala His
            100                 105                 110         
Leu Ser Gln Gly Leu Arg Ser Cys Gly Gly Cys Gly Thr Glu Ile Lys
        115                 120                 125             
Asn Gly Gln Ala Leu Val Ala Leu Asp Lys His Trp His Leu Gly Cys
    130                 135                 140                 
Phe Lys Cys Lys Ser Cys Gly Lys Leu Leu Asn Ala Glu Tyr Ile Ser
145                 150                 155                 160 
Lys Asp Gly Leu Pro Tyr Cys Glu Ala Asp Tyr His Ala Lys Phe Gly
                165                 170                 175     
Ile Arg Cys Asp Ser Cys Glu Lys Tyr Ile Thr Gly Arg Val Leu Glu
            180                 185                 190         
Ala Gly Glu Lys His Tyr His Pro Ser Cys Ala Leu Cys Val Arg Cys
        195                 200                 205             
Gly Gln Met Phe Ala Glu Gly Glu Glu Met Tyr Leu Gln Gly Ser Ser
    210                 215                 220                 
Ile Trp His Pro Ala Cys Arg Gln Ala Ala Arg Thr Glu Asp Arg Asn
225                 230                 235                 240 
Lys Glu Thr Arg Thr Ser Ser Glu Ser Ile Ile Ser Val Pro Ala Ser
                245                 250                 255     
Ser Thr Ser Gly Ser Pro Ser Arg Val Ile Tyr Ala Lys Leu Gly Gly
            260                 265                 270         
Glu Ile Leu Asp Tyr Arg Asp Leu Ala Ala Leu Pro Lys Ser Lys Ala
        275                 280                 285             
Ile Tyr Asp Ile Asp Arg Pro Asp Met Ile Ser Tyr Ser Pro Tyr Ile
    290                 295                 300                 
Ser His Ser Ala Gly Asp Arg Gln Ser Tyr Gly Glu Gly Asp Gln Asp
305                 310                 315                 320 
Asp Arg Ser Tyr Lys Gln Cys Arg Thr Ser Ser Pro Ser Ser Thr Gly
                325                 330                 335     
Ser Val Ser Leu Gly Arg Tyr Thr Pro Thr Ser Arg Ser Pro Gln His
            340                 345                 350         
Tyr Ser Arg Pro Gly Ser Glu Ser Gly Arg Ser Thr Pro Ser Leu Ser
        355                 360                 365             
Val Leu Ser Asp Ser Lys Pro Pro Pro Ser Thr Tyr Gln Gln Ala Pro
    370                 375                 380                 
Arg His Phe His Val Pro Asp Thr Gly Val Lys Asp Asn Ile Tyr Arg
385                 390                 395                 400 
Lys Pro Pro Ile Tyr Arg Gln His Ala Ala Arg Arg Ser Asp Gly Glu
                405                 410                 415     
Asp Gly Ser Leu Asp Gln Asp Asn Arg Lys Lys Ser Ser Trp Leu Met
            420                 425                 430         
Leu Lys Gly Asp Ala Asp Thr Arg Thr Asn Ser Pro Asp Leu Asp Thr
        435                 440                 445             
Gln Ser Leu Ser His Ser Ser Gly Thr Asp Arg Asp Pro Leu Gln Arg
    450                 455                 460                 
Met Ala Gly Asp Ser Phe His Ser Gln Tyr Lys Ile Tyr Pro Tyr Asp
465                 470                 475                 480 
Ser Leu Ile Val Thr Asn Arg Ile Arg Val Lys Leu Pro Lys Asp Val
                485                 490                 495     
Asp Arg Thr Arg Leu Glu Arg His Leu Ser Pro Glu Glu Phe Gln Glu
            500                 505                 510         
Val Phe Gly Met Ser Ile Glu Glu Phe Asp Arg Leu Ala Leu Trp Lys
        515                 520                 525             
Arg Asn Asp Leu Lys Lys Lys Ala Leu Leu Phe
    530                 535                 


<210> 1768
<211> 958
<212> PRT
<213> Homo sapiens

<400> 1768
Gly Arg Gly Arg Gly Gly Gly Ala Ser Gly Gly Gly Gly Gly Ser Ser
 1               5                  10                  15      
Met Lys Arg Arg Ala Gly Leu Gly Gly Ser Met Arg Ser Val Val Gly
            20                  25                  30          
Phe Leu Ser Gln Arg Gly Leu His Gly Asp Pro Leu Leu Thr Gln Asp
        35                  40                  45              
Phe Gln Arg Arg Arg Leu Arg Gly Cys Arg Asn Leu Tyr Lys Lys Asp
    50                  55                  60                  
Leu Leu Gly His Phe Gly Cys Val Asn Ala Ile Glu Phe Ser Asn Asn
65                  70                  75                  80  
Gly Gly Gln Trp Leu Val Ser Gly Gly Asp Asp Arg Arg Val Leu Leu
                85                  90                  95      
Trp His Met Glu Gln Ala Ile His Ser Arg Val Lys Pro Ile Gln Leu
            100                 105                 110         
Lys Gly Glu His His Ser Asn Ile Phe Cys Leu Ala Phe Asn Ser Gly
        115                 120                 125             
Asn Thr Lys Val Phe Ser Gly Gly Asn Asp Glu Gln Val Ile Leu His
    130                 135                 140                 
Asp Val Glu Ser Ser Glu Thr Leu Asp Val Phe Ala His Glu Asp Ala
145                 150                 155                 160 
Val Tyr Gly Leu Ser Val Ser Pro Val Asn Asp Asn Ile Phe Ala Ser
                165                 170                 175     
Ser Ser Asp Asp Gly Arg Val Leu Ile Trp Asp Ile Arg Glu Ser Pro
            180                 185                 190         
His Gly Glu Pro Phe Cys Leu Ala Asn Tyr Pro Ser Ala Phe His Ser
        195                 200                 205             
Val Met Phe Asn Pro Val Glu Pro Arg Leu Leu Ala Thr Ala Asn Ser
    210                 215                 220                 
Lys Glu Gly Val Gly Leu Trp Asp Ile Arg Lys Pro Gln Ser Ser Leu
225                 230                 235                 240 
Leu Arg Tyr Gly Gly Asn Leu Ser Leu Gln Ser Ala Met Ser Val Arg
                245                 250                 255     
Phe Asn Ser Asn Gly Thr Gln Leu Leu Ala Leu Arg Arg Arg Leu Pro
            260                 265                 270         
Pro Val Leu Tyr Asp Ile His Ser Arg Leu Pro Val Phe Gln Phe Asp
        275                 280                 285             
Asn Gln Gly Tyr Phe Asn Ser Cys Thr Met Lys Ser Cys Cys Phe Ala
    290                 295                 300                 
Gly Asp Arg Asp Gln Tyr Ile Leu Ser Gly Ser Asp Asp Phe Asn Leu
305                 310                 315                 320 
Tyr Met Trp Arg Ile Pro Ala Asp Pro Glu Ala Gly Gly Ile Gly Arg
                325                 330                 335     
Val Val Asn Gly Ala Phe Met Val Leu Lys Gly His Arg Ser Ile Val
            340                 345                 350         
Asn Gln Val Arg Phe Asn Pro His Thr Tyr Met Ile Cys Ser Ser Gly
        355                 360                 365             
Val Glu Lys Ile Ile Lys Ile Trp Ser Pro Tyr Lys Gln Pro Gly Cys
    370                 375                 380                 
Thr Gly Asp Leu Asp Gly Arg Ile Glu Asp Asp Ser Arg Cys Leu Tyr
385                 390                 395                 400 
Thr His Glu Glu Tyr Ile Ser Leu Val Leu Asn Ser Gly Ser Gly Leu
                405                 410                 415     
Ser His Asp Tyr Ala Asn Gln Ser Val Gln Glu Asp Pro Arg Met Met
            420                 425                 430         
Ala Phe Phe Asp Ser Leu Val Arg Arg Glu Ile Glu Gly Trp Ser Ser
        435                 440                 445             
Asp Ser Asp Ser Asp Leu Ser Glu Ser Thr Ile Leu Gln Leu His Ala
    450                 455                 460                 
Gly Val Ser Glu Arg Ser Gly Tyr Thr Asp Ser Glu Ser Ser Ala Ser
465                 470                 475                 480 
Leu Pro Arg Ser Pro Pro Pro Thr Val Asp Glu Ser Ala Asp Asn Ala
                485                 490                 495     
Phe His Leu Gly Pro Leu Arg Val Thr Thr Thr Asn Thr Val Ala Ser
            500                 505                 510         
Thr Pro Pro Thr Pro Thr Cys Glu Asp Ala Ala Ser Arg Gln Gln Arg
        515                 520                 525             
Leu Ser Ala Leu Arg Arg Tyr Gln Asp Lys Arg Leu Leu Ala Leu Ser
    530                 535                 540                 
Asn Glu Ser Asp Ser Glu Glu Asn Val Cys Glu Val Glu Leu Asp Thr
545                 550                 555                 560 
Asp Leu Phe Pro Arg Pro Arg Ser Pro Ser Pro Glu Asp Glu Ser Ser
                565                 570                 575     
Ser Ser Ser Ser Ser Ser Ser Ser Glu Asp Glu Glu Glu Leu Asn Glu
            580                 585                 590         
Arg Arg Ala Ser Thr Trp Gln Arg Asn Ala Met Arg Arg Arg Gln Lys
        595                 600                 605             
Thr Thr Arg Glu Asp Lys Pro Ser Ala Pro Ile Lys Pro Thr Asn Thr
    610                 615                 620                 
Tyr Ile Gly Glu Asp Asn Tyr Asp Tyr Pro Gln Ile Lys Val Asp Asp
625                 630                 635                 640 
Leu Ser Ser Ser Pro Thr Ser Ser Pro Glu Arg Ser Thr Ser Thr Leu
                645                 650                 655     
Glu Ile Gln Pro Ser Arg Ala Ser Pro Thr Ser Asp Ile Glu Ser Val
            660                 665                 670         
Glu Arg Lys Ile Tyr Lys Ala Tyr Lys Trp Leu Arg Tyr Ser Tyr Ile
        675                 680                 685             
Ser Tyr Ser Asn Asn Lys Asp Gly Glu Thr Ser Leu Val Thr Gly Glu
    690                 695                 700                 
Ala Asp Glu Gly Arg Ala Gly Thr Ser His Lys Asp Asn Pro Ala Pro
705                 710                 715                 720 
Ser Ser Ser Lys Glu Ala Cys Leu Asn Ile Ala Met Ala Gln Arg Asn
                725                 730                 735     
Gln Asp Leu Pro Pro Glu Gly Cys Ser Lys Asp Thr Phe Lys Glu Glu
            740                 745                 750         
Thr Pro Arg Thr Pro Ser Asn Gly Pro Gly His Glu His Ser Ser His
        755                 760                 765             
Ala Trp Ala Glu Val Pro Glu Gly Thr Ser Gln Asp Thr Gly Asn Ser
    770                 775                 780                 
Gly Ser Val Glu His Pro Phe Glu Thr Lys Lys Leu Asn Gly Lys Ala
785                 790                 795                 800 
Leu Ser Ser Arg Ala Glu Glu Pro Pro Ser Pro Pro Val Pro Lys Ala
                805                 810                 815     
Ser Gly Ser Thr Leu Asn Ser Gly Ser Gly Asn Cys Pro Arg Thr Gln
            820                 825                 830         
Ser Asp Asp Ser Glu Glu Arg Ser Leu Glu Thr Ile Cys Ala Asn His
        835                 840                 845             
Asn Asn Gly Arg Leu His Pro Arg Pro Pro His Pro His Asn Asn Gly
    850                 855                 860                 
Gln Asn Leu Gly Glu Leu Glu Val Val Ala Tyr Ser Ser Pro Gly His
865                 870                 875                 880 
Ser Asp Thr Asp Arg Asp Asn Ser Ser Leu Thr Gly Thr Leu Leu His
                885                 890                 895     
Lys Asp Cys Cys Gly Ser Glu Met Ala Cys Glu Thr Pro Asn Ala Gly
            900                 905                 910         
Thr Arg Glu Asp Pro Thr Asp Thr Pro Ala Thr Asp Ser Ser Arg Ala
        915                 920                 925             
Val His Gly His Ser Gly Leu Lys Arg Gln Arg Ile Glu Leu Glu Asp
    930                 935                 940                 
Thr Asp Ser Glu Asn Ser Ser Ser Glu Lys Lys Leu Lys Thr
945                 950                 955             


<210> 1769
<211> 523
<212> PRT
<213> Homo sapiens

<400> 1769
Leu Arg Asn Ser Gly Leu Ser Tyr Cys Ser Lys Phe Ile Lys Arg Asn
 1               5                  10                  15      
Thr Lys Glu Asn Lys Asp Cys Glu Met Pro Thr Leu Glu Pro Gly Asn
            20                  25                  30          
Val Ile Ser Ile Leu Ile Ser Ser Glu Phe Leu Lys Met Asp Ser Leu
        35                  40                  45              
Val Glu Gln Cys Ile Gln Tyr Cys His Lys Asn Met Asn Ala Ile Val
    50                  55                  60                  
Ala Thr Pro Cys Asn Met Asn Cys Ile Asn Ala Asn Leu Leu Thr Arg
65                  70                  75                  80  
Ile Ala Asp Leu Phe Ser His Asn Glu Val Asp Asp Leu Lys Asp Lys
                85                  90                  95      
Lys Asp Lys Phe Lys Ser Lys Leu Phe Cys Lys Lys Ile Glu Arg Leu
            100                 105                 110         
Phe Asp Pro Glu Tyr Leu Asn Pro Asp Ser Arg Ser Asn Ala Ala Thr
        115                 120                 125             
Leu Tyr Arg Cys Cys Leu Cys Lys Lys Leu Leu Thr Lys Glu Thr Glu
    130                 135                 140                 
Arg Arg Ile Pro Cys Ile Pro Gly Lys Ile Asn Val Asp Arg Arg Gly
145                 150                 155                 160 
Asn Ile Val Tyr Ile His Ile Arg Asp Lys Thr Trp Asp Val His Glu
                165                 170                 175     
Tyr Leu Asn Ser Leu Phe Glu Glu Leu Lys Ser Trp Arg Asp Val Tyr
            180                 185                 190         
Trp Arg Leu Trp Gly Thr Ile Asn Trp Leu Thr Cys Ser Arg Cys Tyr
        195                 200                 205             
Gln Ala Phe Leu Cys Ile Glu Phe Ser His Cys Gln Tyr His Ser Glu
    210                 215                 220                 
Thr Val Val Tyr Pro Thr Ala Ala Ser Ser Leu Asn Thr Val Gly Thr
225                 230                 235                 240 
Gly Ile Tyr Pro Cys Cys Asn Gln Lys Val Leu Arg Phe Asp Pro Thr
                245                 250                 255     
Gln Leu Thr Lys Gly Cys Lys Val Arg Asp His Met Val Thr Leu Arg
            260                 265                 270         
Asp Gln Gly Glu Gly Gly Asp Leu Pro Ser Cys Pro Thr Ala Arg Met
        275                 280                 285             
Leu Asp Asp Leu His Lys Tyr Arg Asp Val Ile Val Val Pro Phe Ser
    290                 295                 300                 
Lys Asp Thr Val Ser Asp Val Gly Val Gly Leu Cys Asp Glu Lys Gly
305                 310                 315                 320 
Ile Glu Cys Asp Val Leu Leu Glu Pro Asn Thr Pro Trp Gly Pro Lys
                325                 330                 335     
Thr Gly Glu Leu Asn Ala Phe Leu Ser Leu Lys Asn Trp Thr Leu Gln
            340                 345                 350         
Leu Lys Gln Gln Ser Leu Phe Ser Glu Glu Glu Glu Tyr Thr Thr Gly
        355                 360                 365             
Ser Glu Val Thr Glu Asp Glu Val Gly Asp Glu Glu Glu Val Ser Lys
    370                 375                 380                 
Lys Gln Arg Lys Lys Glu Lys Pro Lys Lys Phe Thr Arg Gln Pro Lys
385                 390                 395                 400 
Lys Gln Val Ser Ser Pro Cys Ala Gln Arg Lys Glu Lys Ala Leu Glu
                405                 410                 415     
Lys Ser Ala Ser Arg Asp Val Ser Pro Phe Val Met Ser Met Gln Lys
            420                 425                 430         
Asn Lys Trp Asp Ala Thr Arg Ser Leu Arg Phe Asn Gln Asp Ala Gln
        435                 440                 445             
Arg Glu Asp Asp Gln Arg Arg Met Thr Glu Ile Thr Gly His Leu Ile
    450                 455                 460                 
Lys Met Arg Leu Gly Asp Leu Asp Arg Val Lys Ser Lys Glu Ala Lys
465                 470                 475                 480 
Glu Phe Ala Gly Gly Ile Tyr Ser Arg Leu Glu Ala Gln Ile Lys Ala
                485                 490                 495     
Ser Val Pro Val Ser Ala Arg Gln Ser Ser Ser Glu Lys Asn Thr Arg
            500                 505                 510         
Ser Lys Ser Arg Phe Gly Gln Gly Arg Pro Ala
        515                 520             


<210> 1770
<211> 1341
<212> PRT
<213> Homo sapiens

<400> 1770
Val Asn Pro Ser Lys Cys Gly Cys Pro Phe Ala Leu Lys Met Ala Ala
 1               5                  10                  15      
Cys Gln Leu Leu Leu Glu Ile Thr Thr Phe Leu Arg Glu Thr Phe Ser
            20                  25                  30          
Cys Leu Pro Arg Pro Arg Thr Glu Pro Leu Val Asp Leu Glu Ser Cys
        35                  40                  45              
Arg Leu Arg Leu Asp Pro Glu Leu Asp Arg His Arg Tyr Glu Arg Lys
    50                  55                  60                  
Ile Ser Phe Ala Gly Val Leu Asp Glu Asn Glu Asp Ser Lys Asp Ser
65                  70                  75                  80  
Leu His Ser Ser Ser His Thr Leu Lys Ser Asp Ala Gly Val Glu Glu
                85                  90                  95      
Lys Lys Val Pro Ser Arg Lys Ile Arg Ile Gly Gly Ser Arg Leu Leu
            100                 105                 110         
Gln Ile Lys Gly Thr Arg Ser Phe Gln Val Lys Lys Gly Gly Ser Leu
        115                 120                 125             
Ser Ser Ile Arg Arg Val Gly Ser Leu Lys Ser Ser Lys Leu Ser Arg
    130                 135                 140                 
Gln Asp Ser Glu Ser Glu Ala Glu Glu Leu Gln Leu Ser Gln Ser Arg
145                 150                 155                 160 
Asp Thr Val Thr Asp Leu Glu Gly Ser Pro Trp Ser Ala Ser Glu Pro
                165                 170                 175     
Ser Ile Glu Pro Glu Gly Met Ser Asn Ala Gly Ala Glu Glu Asn Tyr
            180                 185                 190         
His Arg Asn Met Ser Trp Leu His Val Met Ile Leu Leu Cys Asn Gln
        195                 200                 205             
Gln Ser Phe Ile Cys Thr His Val Asp Tyr Cys His Pro His Cys Tyr
    210                 215                 220                 
Leu His His Ser Arg Ser Cys Ala Arg Leu Val Arg Ala Ile Lys Leu
225                 230                 235                 240 
Leu Tyr Gly Asp Ser Val Asp Ser Leu Arg Glu Ser Ser Asn Ile Ser
                245                 250                 255     
Ser Val Ala Leu Arg Gly Lys Lys Gln Lys Glu Cys Ser Asp Lys Ser
            260                 265                 270         
Cys Leu Arg Thr Pro Ser Leu Lys Lys Arg Val Ser Asp Ala Asn Leu
        275                 280                 285             
Glu Gly Lys Lys Asp Ser Gly Met Leu Lys Tyr Ile Arg Leu Gln Val
    290                 295                 300                 
Met Ser Leu Ser Pro Ala Pro Leu Ser Leu Leu Ile Lys Ala Ala Pro
305                 310                 315                 320 
Ile Leu Thr Glu Glu Met Tyr Gly Asp Ile Gln Pro Ala Ala Trp Glu
                325                 330                 335     
Leu Leu Leu Ser Met Asp Glu His Met Ala Gly Ala Ala Ala Ala Met
            340                 345                 350         
Phe Leu Leu Cys Ala Val Lys Val Pro Glu Ala Val Ser Asp Met Leu
        355                 360                 365             
Met Ser Glu Phe His His Pro Glu Thr Val Gln Arg Leu Asn Ala Val
    370                 375                 380                 
Leu Lys Phe His Thr Leu Trp Arg Phe Arg Tyr Gln Val Trp Pro Arg
385                 390                 395                 400 
Met Glu Glu Gly Ala Gln Gln Ile Phe Lys Ile Pro Pro Pro Ser Ile
                405                 410                 415     
Asn Phe Thr Leu Pro Ser Pro Val Leu Gly Met Pro Ser Val Pro Met
            420                 425                 430         
Phe Asp Pro Pro Trp Val Pro Gln Cys Ser Gly Ser Val Gln Asp Pro
        435                 440                 445             
Ile Asn Glu Asp Gln Ser Lys Ser Phe Ser Ala Arg Ala Val Ser Arg
    450                 455                 460                 
Ser His Gln Arg Ala Glu His Ile Leu Lys Asn Leu Gln Gln Glu Glu
465                 470                 475                 480 
Glu Lys Lys Arg Leu Gly Arg Glu Ala Ser Leu Ile Thr Ala Ile Pro
                485                 490                 495     
Ile Thr Gln Glu Ala Cys Tyr Glu Pro Thr Cys Thr Pro Asn Ser Glu
            500                 505                 510         
Pro Glu Glu Glu Glu Glu Val Thr Asn Leu Ala Ser Arg Arg Leu Ser
        515                 520                 525             
Val Ser Pro Ser Cys Thr Ser Ser Thr Ser His Arg Asn Tyr Ser Phe
    530                 535                 540                 
Arg Arg Gly Ser Val Trp Ser Val Arg Ser Ala Val Ser Ala Glu Asp
545                 550                 555                 560 
Glu Glu His Thr Thr Glu His Thr Pro Asn His His Val Pro Gln Pro
                565                 570                 575     
Pro Gln Ala Val Phe Pro Ala Cys Ile Cys Ala Ala Val Leu Pro Ile
            580                 585                 590         
Val His Leu Met Glu Asp Gly Glu Val Arg Glu Asp Gly Val Ala Val
        595                 600                 605             
Ser Ala Val Ala Gln Gln Val Leu Trp Asn Cys Leu Ile Glu Asp Pro
    610                 615                 620                 
Ser Thr Val Leu Arg His Phe Leu Glu Lys Leu Thr Ile Ser Asn Arg
625                 630                 635                 640 
Gln Asp Glu Leu Met Tyr Met Leu Arg Lys Leu Leu Leu Asn Ile Gly
                645                 650                 655     
Asp Phe Pro Ala Gln Thr Ser His Ile Leu Phe Asn Tyr Leu Val Gly
            660                 665                 670         
Leu Ile Met Tyr Phe Val Arg Thr Pro Cys Glu Trp Gly Met Asp Ala
        675                 680                 685             
Ile Ser Ala Thr Leu Thr Phe Leu Trp Glu Val Val Gly Tyr Val Glu
    690                 695                 700                 
Gly Leu Phe Phe Lys Asp Leu Lys Gln Thr Met Lys Lys Glu Gln Cys
705                 710                 715                 720 
Glu Val Lys Leu Leu Val Thr Ala Ser Met Pro Gly Thr Lys Thr Leu
                725                 730                 735     
Val Val His Gly Gln Asn Glu Cys Asp Ile Pro Thr Gln Leu Pro Val
            740                 745                 750         
His Glu Asp Thr Gln Phe Glu Ala Leu Leu Lys Glu Cys Leu Glu Phe
        755                 760                 765             
Phe Asn Ile Pro Glu Ser Gln Ser Thr His Tyr Phe Leu Met Asp Lys
    770                 775                 780                 
Arg Trp Asn Leu Ile His Tyr Asn Lys Thr Tyr Val Arg Asp Ile Tyr
785                 790                 795                 800 
Pro Phe Arg Arg Ser Val Ser Pro Gln Leu Asn Leu Val His Met His
                805                 810                 815     
Pro Glu Lys Gly Gln Glu Leu Ile Gln Lys Gln Val Phe Thr Arg Lys
            820                 825                 830         
Leu Glu Glu Val Gly Arg Val Leu Phe Leu Ile Ser Leu Thr Gln Lys
        835                 840                 845             
Ile Pro Thr Ala His Lys Gln Ser His Val Ser Met Leu Gln Glu Asp
    850                 855                 860                 
Leu Leu Arg Leu Pro Ser Phe Pro Arg Ser Ala Ile Asp Ala Glu Phe
865                 870                 875                 880 
Ser Leu Phe Ser Asp Pro Gln Ala Gly Lys Glu Leu Phe Gly Leu Asp
                885                 890                 895     
Thr Leu Gln Lys Ser Leu Trp Ile Gln Leu Leu Glu Glu Met Phe Leu
            900                 905                 910         
Gly Met Pro Ser Glu Phe Pro Trp Gly Asp Glu Ile Met Leu Phe Leu
        915                 920                 925             
Asn Val Phe Asn Gly Ala Leu Ile Leu His Pro Glu Asp Ser Ala Leu
    930                 935                 940                 
Leu Arg Gln Tyr Ala Ala Thr Val Ile Asn Thr Ala Val His Phe Asn
945                 950                 955                 960 
His Leu Phe Ser Leu Ser Gly Tyr Gln Trp Ile Leu Pro Thr Met Leu
                965                 970                 975     
Gln Val Tyr Ser Asp Tyr Glu Ser Asn Pro Gln Leu Arg Gln Ala Ile
            980                 985                 990         
Glu Phe Ala Cys His Gln Phe Tyr Ile Leu His Arg Lys Pro Phe Val
        995                 1000                1005            
Leu Gln Leu Phe Ala Ser Val Ala Pro Leu Leu Glu Phe Pro Asp Ala
    1010                1015                1020                
Ala Asn Asn Gly Pro Ser Lys Gly Val Ser Ala Gln Cys Leu Phe Asp
1025                1030                1035                1040
Leu Leu Gln Ser Leu Glu Gly Glu Thr Thr Asp Ile Leu Asp Ile Leu
                1045                1050                1055    
Glu Leu Val Lys Ala Glu Lys Pro Leu Lys Ser Leu Asp Phe Cys Tyr
            1060                1065                1070        
Gly Asn Glu Asp Leu Thr Phe Ser Ile Ser Glu Ala Ile Lys Leu Cys
        1075                1080                1085            
Val Thr Val Val Ala Tyr Ala Pro Glu Ser Phe Arg Ser Leu Gln Met
    1090                1095                1100                
Leu Met Val Leu Glu Ala Leu Val Pro Cys Tyr Leu Gln Lys Leu Lys
1105                1110                1115                1120
Arg Gln Thr Ser Gln Val Glu Thr Val Pro Ala Ala Arg Glu Glu Ile
                1125                1130                1135    
Ala Ala Thr Ala Ala Leu Ala Thr Ser Leu Gln Ala Leu Leu Tyr Ser
            1140                1145                1150        
Val Glu Val Leu Thr Arg Pro Met Thr Ala Pro Gln Met Ser Arg Cys
        1155                1160                1165            
Asp Gln Gly His Lys Gly Thr Thr Thr Ala Asn His Thr Met Ser Ser
    1170                1175                1180                
Gly Val Asn Thr Arg Tyr Gln Glu Gln Gly Ala Lys Leu His Phe Ile
1185                1190                1195                1200
Arg Glu Asn Leu His Leu Leu Glu Glu Gly Gln Gly Ile Pro Arg Glu
                1205                1210                1215    
Glu Leu Asp Glu Arg Ile Ala Arg Glu Glu Phe Arg Arg Pro Arg Glu
            1220                1225                1230        
Ser Leu Leu Asn Ile Cys Thr Glu Phe Tyr Lys His Cys Gly Pro Arg
        1235                1240                1245            
Leu Lys Ile Leu Gln Asn Leu Ala Gly Glu Pro Arg Val Ile Ala Leu
    1250                1255                1260                
Glu Leu Leu Asp Val Lys Ser His Met Arg Leu Ala Glu Ile Ala His
1265                1270                1275                1280
Ser Leu Leu Lys Leu Ala Pro Tyr Asp Thr Gln Thr Met Glu Ser Arg
                1285                1290                1295    
Gly Leu Arg Arg Tyr Ile Met Glu Met Leu Pro Ile Thr Asp Trp Thr
            1300                1305                1310        
Ala Glu Ala Val Arg Pro Ala Leu Ile Leu Ile Leu Lys Arg Leu Asp
        1315                1320                1325            
Arg Met Phe Asn Lys Ile His Lys Met Pro Thr Leu Arg
    1330                1335                1340    


<210> 1771
<211> 1341
<212> PRT
<213> Homo sapiens

<400> 1771
Val Asn Pro Ser Lys Cys Gly Cys Pro Phe Ala Leu Lys Met Ala Ala
 1               5                  10                  15      
Cys Gln Leu Leu Leu Glu Ile Thr Thr Phe Leu Arg Glu Thr Phe Ser
            20                  25                  30          
Cys Leu Pro Arg Pro Arg Thr Glu Pro Leu Val Asp Leu Glu Ser Cys
        35                  40                  45              
Arg Leu Arg Leu Asp Pro Glu Leu Asp Arg His Arg Tyr Glu Arg Lys
    50                  55                  60                  
Ile Ser Phe Ala Gly Val Leu Asp Glu Asn Glu Asp Ser Lys Asp Ser
65                  70                  75                  80  
Leu His Ser Ser Ser His Thr Leu Lys Ser Asp Ala Gly Val Glu Glu
                85                  90                  95      
Lys Lys Val Pro Ser Arg Lys Ile Arg Ile Gly Gly Ser Arg Leu Leu
            100                 105                 110         
Gln Ile Lys Gly Thr Arg Ser Phe Gln Val Lys Lys Gly Gly Ser Leu
        115                 120                 125             
Ser Ser Ile Arg Arg Val Gly Ser Leu Lys Ser Ser Lys Leu Ser Arg
    130                 135                 140                 
Gln Asp Ser Glu Ser Glu Ala Glu Glu Leu Gln Leu Ser Gln Ser Arg
145                 150                 155                 160 
Asp Thr Val Thr Asp Leu Glu Gly Ser Pro Trp Ser Ala Ser Glu Pro
                165                 170                 175     
Ser Ile Glu Pro Glu Gly Met Ser Asn Ala Gly Ala Glu Glu Asn Tyr
            180                 185                 190         
His Arg Asn Met Ser Trp Leu His Val Met Ile Leu Leu Cys Asn Gln
        195                 200                 205             
Gln Ser Phe Ile Cys Thr His Val Asp Tyr Cys His Pro His Cys Tyr
    210                 215                 220                 
Leu His His Ser Arg Ser Cys Ala Arg Leu Val Arg Ala Ile Lys Leu
225                 230                 235                 240 
Leu Tyr Gly Asp Ser Val Asp Ser Leu Arg Glu Ser Ser Asn Ile Ser
                245                 250                 255     
Ser Val Ala Leu Arg Gly Lys Lys Gln Lys Glu Cys Ser Asp Lys Ser
            260                 265                 270         
Cys Leu Arg Thr Pro Ser Leu Lys Lys Arg Val Ser Asp Ala Asn Leu
        275                 280                 285             
Glu Gly Lys Lys Asp Ser Gly Met Leu Lys Tyr Ile Arg Leu Gln Val
    290                 295                 300                 
Met Ser Leu Ser Pro Ala Pro Leu Ser Leu Leu Ile Lys Ala Ala Pro
305                 310                 315                 320 
Ile Leu Thr Glu Glu Met Tyr Gly Asp Ile Gln Pro Ala Ala Trp Glu
                325                 330                 335     
Leu Leu Leu Ser Met Asp Glu His Met Ala Gly Ala Ala Ala Ala Met
            340                 345                 350         
Phe Leu Leu Cys Ala Val Lys Val Pro Glu Ala Val Ser Asp Met Leu
        355                 360                 365             
Met Ser Glu Phe His His Pro Glu Thr Val Gln Arg Leu Asn Ala Val
    370                 375                 380                 
Leu Lys Phe His Thr Leu Trp Arg Phe Arg Tyr Gln Val Trp Pro Arg
385                 390                 395                 400 
Met Glu Glu Gly Ala Gln Gln Ile Phe Lys Ile Pro Pro Pro Ser Ile
                405                 410                 415     
Asn Phe Thr Leu Pro Ser Pro Val Leu Gly Met Pro Ser Val Pro Met
            420                 425                 430         
Phe Asp Pro Pro Trp Val Pro Gln Cys Ser Gly Ser Val Gln Asp Pro
        435                 440                 445             
Ile Asn Glu Asp Gln Ser Lys Ser Phe Ser Ala Arg Ala Val Ser Arg
    450                 455                 460                 
Ser His Gln Arg Ala Glu His Ile Leu Lys Asn Leu Gln Gln Glu Glu
465                 470                 475                 480 
Glu Lys Lys Arg Leu Gly Arg Glu Ala Ser Leu Ile Thr Ala Ile Pro
                485                 490                 495     
Ile Thr Gln Glu Ala Cys Tyr Glu Pro Thr Cys Thr Pro Asn Ser Glu
            500                 505                 510         
Pro Glu Glu Glu Glu Glu Val Thr Asn Leu Ala Ser Arg Arg Leu Ser
        515                 520                 525             
Val Ser Pro Ser Cys Thr Ser Ser Thr Ser His Arg Asn Tyr Ser Phe
    530                 535                 540                 
Arg Arg Gly Ser Val Trp Ser Val Arg Ser Ala Val Ser Ala Glu Asp
545                 550                 555                 560 
Glu Glu His Thr Thr Glu His Thr Pro Asn His His Val Pro Gln Pro
                565                 570                 575     
Pro Gln Ala Val Phe Pro Ala Cys Ile Cys Ala Ala Val Leu Pro Ile
            580                 585                 590         
Val His Leu Met Glu Asp Gly Glu Val Arg Glu Asp Gly Val Ala Val
        595                 600                 605             
Ser Ala Val Ala Gln Gln Val Leu Trp Asn Cys Leu Ile Glu Asp Pro
    610                 615                 620                 
Ser Thr Val Leu Arg His Phe Leu Glu Lys Leu Thr Ile Ser Asn Arg
625                 630                 635                 640 
Gln Asp Glu Leu Met Tyr Met Leu Arg Lys Leu Leu Leu Asn Ile Gly
                645                 650                 655     
Asp Phe Pro Ala Gln Thr Ser His Ile Leu Phe Asn Tyr Leu Val Gly
            660                 665                 670         
Leu Ile Met Tyr Phe Val Arg Thr Pro Cys Glu Trp Gly Met Asp Ala
        675                 680                 685             
Ile Ser Ala Thr Leu Thr Phe Leu Trp Glu Val Val Gly Tyr Val Glu
    690                 695                 700                 
Gly Leu Phe Phe Lys Asp Leu Lys Gln Thr Met Lys Lys Glu Gln Cys
705                 710                 715                 720 
Glu Val Lys Leu Leu Val Thr Ala Ser Met Pro Gly Thr Lys Thr Leu
                725                 730                 735     
Val Val His Gly Gln Asn Glu Cys Asp Ile Pro Thr Gln Leu Pro Val
            740                 745                 750         
His Glu Asp Thr Gln Phe Glu Ala Leu Leu Lys Glu Cys Leu Glu Phe
        755                 760                 765             
Phe Asn Ile Pro Glu Ser Gln Ser Thr His Tyr Phe Leu Met Asp Lys
    770                 775                 780                 
Arg Trp Asn Leu Ile His Tyr Asn Lys Thr Tyr Val Arg Asp Ile Tyr
785                 790                 795                 800 
Pro Phe Arg Arg Ser Val Ser Pro Gln Leu Asn Leu Val His Met His
                805                 810                 815     
Pro Glu Lys Gly Gln Glu Leu Ile Gln Lys Gln Val Phe Thr Arg Lys
            820                 825                 830         
Leu Glu Glu Val Gly Arg Val Leu Phe Leu Ile Ser Leu Thr Gln Lys
        835                 840                 845             
Ile Pro Thr Ala His Lys Gln Ser His Val Ser Met Leu Gln Glu Asp
    850                 855                 860                 
Leu Leu Arg Leu Pro Ser Phe Pro Arg Ser Ala Ile Asp Ala Glu Phe
865                 870                 875                 880 
Ser Leu Phe Ser Asp Pro Gln Ala Gly Lys Glu Leu Phe Gly Leu Asp
                885                 890                 895     
Thr Leu Gln Lys Ser Leu Trp Ile Gln Leu Leu Glu Glu Met Phe Leu
            900                 905                 910         
Gly Met Pro Ser Glu Phe Pro Trp Gly Asp Glu Ile Met Leu Phe Leu
        915                 920                 925             
Asn Val Phe Asn Gly Ala Leu Ile Leu His Pro Glu Asp Ser Ala Leu
    930                 935                 940                 
Leu Arg Gln Tyr Ala Ala Thr Val Ile Asn Thr Ala Val His Phe Asn
945                 950                 955                 960 
His Leu Phe Ser Leu Ser Gly Tyr Gln Trp Ile Leu Pro Thr Met Leu
                965                 970                 975     
Gln Val Tyr Ser Asp Tyr Glu Ser Asn Pro Gln Leu Arg Gln Ala Ile
            980                 985                 990         
Glu Phe Ala Cys His Gln Phe Tyr Ile Leu His Arg Lys Pro Phe Val
        995                 1000                1005            
Leu Gln Leu Phe Ala Ser Val Ala Pro Leu Leu Glu Phe Pro Asp Ala
    1010                1015                1020                
Ala Asn Asn Gly Pro Ser Lys Gly Val Ser Ala Gln Cys Leu Phe Asp
1025                1030                1035                1040
Leu Leu Gln Ser Leu Glu Gly Glu Thr Thr Asp Ile Leu Asp Ile Leu
                1045                1050                1055    
Glu Leu Val Lys Ala Glu Lys Pro Leu Lys Ser Leu Asp Phe Cys Tyr
            1060                1065                1070        
Gly Asn Glu Asp Leu Thr Phe Ser Ile Ser Glu Ala Ile Lys Leu Cys
        1075                1080                1085            
Val Thr Val Val Ala Tyr Ala Pro Glu Ser Phe Arg Ser Leu Gln Met
    1090                1095                1100                
Leu Met Val Leu Glu Ala Leu Val Pro Cys Tyr Leu Gln Lys Leu Lys
1105                1110                1115                1120
Arg Gln Thr Ser Gln Val Glu Thr Val Pro Ala Ala Arg Glu Glu Ile
                1125                1130                1135    
Ala Ala Thr Ala Ala Leu Ala Thr Ser Leu Gln Ala Leu Leu Tyr Ser
            1140                1145                1150        
Val Glu Val Leu Thr Arg Pro Met Thr Ala Pro Gln Met Ser Arg Cys
        1155                1160                1165            
Asp Gln Gly His Lys Gly Thr Thr Thr Ala Asn His Thr Met Ser Ser
    1170                1175                1180                
Gly Val Asn Thr Arg Tyr Gln Glu Gln Gly Ala Lys Leu His Phe Ile
1185                1190                1195                1200
Arg Glu Asn Leu His Leu Leu Glu Glu Gly Gln Gly Ile Pro Arg Glu
                1205                1210                1215    
Glu Leu Asp Glu Arg Ile Ala Arg Glu Glu Phe Arg Arg Pro Arg Glu
            1220                1225                1230        
Ser Leu Leu Asn Ile Cys Thr Glu Phe Tyr Lys His Cys Gly Pro Arg
        1235                1240                1245            
Leu Lys Ile Leu Gln Asn Leu Ala Gly Glu Pro Arg Val Ile Ala Leu
    1250                1255                1260                
Glu Leu Leu Asp Val Lys Ser His Met Arg Leu Ala Glu Ile Ala His
1265                1270                1275                1280
Ser Leu Leu Lys Leu Ala Pro Tyr Asp Thr Gln Thr Met Glu Ser Arg
                1285                1290                1295    
Gly Leu Arg Arg Tyr Ile Met Glu Met Leu Pro Ile Thr Asp Trp Thr
            1300                1305                1310        
Ala Glu Ala Val Arg Pro Ala Leu Ile Leu Ile Leu Lys Arg Leu Asp
        1315                1320                1325            
Arg Met Phe Asn Lys Ile His Lys Met Pro Thr Leu Arg
    1330                1335                1340    


<210> 1772
<211> 708
<212> PRT
<213> Homo sapiens

<400> 1772
Arg Lys Pro Ala Leu Pro Ser Leu Leu Gly Ala Gln Arg Leu Ser Gln
 1               5                  10                  15      
Leu Arg Ala Gln Pro Gly Ala Asp Pro Glu Gly Arg Arg Lys Pro Ser
            20                  25                  30          
Gly Arg Ala Ser Phe Leu Cys Cys Leu Pro Gly Leu Gly Arg Pro Ile
        35                  40                  45              
Pro Arg Pro Glu Leu Arg Ser Leu Pro Pro His Pro Ser Leu Gly Phe
    50                  55                  60                  
Thr Arg Thr Glu Pro Gly Ala Gly Cys Arg Pro Arg Leu Glu Ser Thr
65                  70                  75                  80  
Phe Gln His Phe Gly Gln Arg Pro Gly Arg Pro Gly Pro Phe Gly Leu
                85                  90                  95      
Ala Met Ala Ser Val Gln Gln Gly Glu Lys Gln Leu Phe Glu Lys Phe
            100                 105                 110         
Trp Arg Gly Thr Phe Lys Ala Val Ala Thr Pro Arg Pro Glu Ser Ile
        115                 120                 125             
Ile Val Ala Ser Ile Thr Ala Arg Lys Pro Leu Pro Arg Thr Glu Pro
    130                 135                 140                 
Gln Asn Asn Pro Val Val Pro Ala Gln Asp Gly Pro Ser Glu Lys Leu
145                 150                 155                 160 
Gly Gln His Leu Ala Thr Glu Pro Leu Gly Thr Asn Ser Trp Glu Arg
                165                 170                 175     
Asp Lys Thr Cys Arg Glu Leu Gly Ala Thr Arg Gly His Ser Ala Ser
            180                 185                 190         
His Asp Lys Asp Leu Thr Pro Pro Pro Ser Ser Arg Gly Lys Lys Lys
        195                 200                 205             
Lys Lys Lys Ser Thr Arg Lys Lys Arg Arg Arg Ser Ser Ser Tyr Ser
    210                 215                 220                 
Pro Ser Pro Val Lys Lys Lys Lys Lys Lys Ser Ser Lys Lys His Lys
225                 230                 235                 240 
Arg Arg Arg Ser Phe Ser Lys Lys Arg Arg His Ser Ser Ser Ser Pro
                245                 250                 255     
Lys Ser Lys Arg Arg Asp Glu Lys Arg His Lys Lys Gln Ser Arg Ser
            260                 265                 270         
Arg Pro Arg Lys Ser His Arg His Arg His His Arg Cys Pro Ser Arg
        275                 280                 285             
Ser Gln Ser Ser Glu Ser Arg Pro Ser Ser Cys Glu Ser Arg His Arg
    290                 295                 300                 
Gly Arg Ser Pro Glu Glu Gly Gln Lys Ser Arg Arg Arg His Ser Arg
305                 310                 315                 320 
Arg Cys Ser Lys Thr Leu Cys Lys Asp Ser Pro Glu Ala Gln Ser Ser
                325                 330                 335     
Arg Pro Pro Ser Gln Pro Leu Gln Met Leu Gly Tyr Leu Ser Ala Arg
            340                 345                 350         
Gly Val Ile Thr Gly Ser Gly Ser Ala Ala Asp Leu Phe Thr Lys Thr
        355                 360                 365             
Ala Ser Pro Leu Thr Thr Ser Arg Gly Arg Ser Gln Glu Tyr Asp Ser
    370                 375                 380                 
Gly Asn Asp Thr Ser Ser Pro Pro Ser Thr Gln Thr Ser Ser Ala Arg
385                 390                 395                 400 
Ser Arg Gly Gln Glu Lys Gly Ser Pro Ser Gly Gly Leu Ser Lys Ser
                405                 410                 415     
Arg Glu Leu Asn Ser Gly Asn Thr Ser Asp Ser Gly Asn Ser Phe Thr
            420                 425                 430         
Thr Ser Ser Pro Gln Asn Lys Gly Ala Met Leu Glu Asn Leu Ser Pro
        435                 440                 445             
Thr Ser Arg Gly Arg Glu Ser Arg Gly Phe Gln Ser Pro Cys Leu Glu
    450                 455                 460                 
Cys Ala Glu Val Lys Lys Ser Ser Leu Val Pro Ser Thr Ala Arg Ser
465                 470                 475                 480 
Ser Pro Met Lys Gly Cys Ser Arg Ser Ser Ser Tyr Ala Ser Thr Arg
                485                 490                 495     
Ser Ser Ser His Ser Ser Arg Ser Pro Asn Pro Arg Ala Ser Pro Arg
            500                 505                 510         
Tyr Thr Gln Ser Arg Ser Thr Ser Ser Glu Lys Arg Ser Tyr Ser Arg
        515                 520                 525             
Ser Pro Ser Tyr Ser Ser Lys Ser Gly Lys Arg Ser Pro Pro Ser Arg
    530                 535                 540                 
Ser Ser Arg Ser Arg Arg Ser Pro Ser Tyr Ser Arg Tyr Ser Pro Ser
545                 550                 555                 560 
Arg Glu Arg Asp Pro Lys Tyr Ser Glu Lys Asp Ser Gln Gln Arg Glu
                565                 570                 575     
Arg Glu Arg Ala Arg Arg Arg Arg Arg Ser Tyr Ser Pro Met Arg Lys
            580                 585                 590         
Arg Arg Arg Asp Ser Pro Ser His Leu Glu Ala Arg Arg Ile Thr Ser
        595                 600                 605             
Ala Arg Lys Arg Pro Ile Pro Tyr Tyr Arg Pro Ser Pro Ser Ser Ser
    610                 615                 620                 
Gly Ser Leu Ser Ser Thr Ser Ser Trp Tyr Ser Ser Ser Ser Ser Arg
625                 630                 635                 640 
Ser Ala Ser Arg Ser Tyr Ser Arg Ser Trp Ser Arg Ser Arg Ser Arg
                645                 650                 655     
Arg Arg Ser Arg Thr Arg Thr Ser Ser Ser Ser Ser Ser Arg Ser Pro
            660                 665                 670         
Ser Pro Gly Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser
        675                 680                 685             
Arg Ser Arg Ser Gln Ser Arg Ser Tyr Ser Ser Ala Asp Ser Tyr Ser
    690                 695                 700                 
Ser Thr Arg Arg
705             


<210> 1773
<211> 624
<212> PRT
<213> Homo sapiens

<400> 1773
Glu Gly Gln Glu Pro Ala Gly Cys Gly Asp Pro Gln Gly Gly Gln Pro
 1               5                  10                  15      
Arg His Ser Leu His Leu Thr Ala Leu Val Gln Leu Val Lys Glu Ile
            20                  25                  30          
Pro Glu Phe Leu Phe Gly Glu Val Lys Gly Ala Met Asp Ser Pro Glu
        35                  40                  45              
Ser Glu Ser Arg Gly Ala Ser Leu Asp Gly Glu Arg Ala Ser Pro Glu
    50                  55                  60                  
Ala Ala Ala Arg Glu Pro Cys Pro Leu Arg Gly Leu Leu Ser Cys Leu
65                  70                  75                  80  
Pro Asp Gly Pro Thr Ser Gln Pro His Leu Ala Thr Thr Pro Thr Asp
                85                  90                  95      
Ser Ser Cys Ser Ser Gly Pro Thr Gly Asp Gly Val Gln Gly Ser Pro
            100                 105                 110         
Leu Pro Ile Lys Thr Ala Asp Lys Pro Trp Pro Thr Arg Lys Glu Gly
        115                 120                 125             
Pro Gly Ala Leu Gly Gly Glu Pro Ser Pro Pro Thr His Ser Pro Ser
    130                 135                 140                 
Arg Arg Lys Ser His Arg Gly Gln Glu Arg Gly Thr Ser Glu Ala Gly
145                 150                 155                 160 
Ile Ser Pro Gly Asn Ser Pro Leu Gln Gly Leu Ile Asn Cys Leu Lys
                165                 170                 175     
Glu Ile Leu Val Pro Gly Pro Arg His Pro Glu Thr Ser Pro Ser Phe
            180                 185                 190         
Leu Pro Pro Leu Pro Ser Leu Gly Thr Ser Arg Leu Thr Arg Ala Asp
        195                 200                 205             
Leu Gly Pro Gly Ser Pro Pro Trp Ala Val Lys Thr Glu Ala Val Ser
    210                 215                 220                 
Gly Asp Cys Pro Leu Gln Gly Leu Leu His Cys Leu Lys Glu Leu Pro
225                 230                 235                 240 
Glu Ala Gln Asp Arg His Pro Ser Pro Ser Gly Val Gly Asn Arg Arg
                245                 250                 255     
Leu Gln Glu Asn Pro Gly Ala Trp Lys Arg Gly Ser Gly Gly Pro Gly
            260                 265                 270         
Tyr Leu Leu Thr Pro Pro Pro His Pro Asp Leu Gly Ala Gly Gly Leu
        275                 280                 285             
Leu Ser Val Lys Met Glu Asn Ser Trp Val Gln Ser Pro Pro Gly Pro
    290                 295                 300                 
Ala Ser Cys Gln Pro Gly Arg Gln Pro Leu Ser Pro Ser Ala Thr Gly
305                 310                 315                 320 
Asp Thr Arg Gly Val Pro Gln Pro Ser Trp Gly Pro Glu Ala Gln Ala
                325                 330                 335     
Ala Ser Ala Ser Ser Ser Pro Leu Glu Ala Leu Glu Ala Cys Leu Lys
            340                 345                 350         
Gly Ile Pro Pro Asn Gly Ser Ser Pro Ser Gln Leu Pro Pro Thr Ser
        355                 360                 365             
Cys Ser Gln Asn Pro Gln Pro Gly Asp Ser Arg Ser Gln Lys Pro Glu
    370                 375                 380                 
Leu Gln Pro His Arg Ser His Ser Glu Glu Ala Thr Arg Glu Pro Val
385                 390                 395                 400 
Leu Pro Leu Gly Leu Gln Ser Cys Val Arg Asp Gly Pro Ser Arg Pro
                405                 410                 415     
Leu Ala Pro Arg Gly Thr Pro Thr Ser Phe Ser Ser Ser Ser Ser Thr
            420                 425                 430         
Asp Trp Asp Leu Asp Phe Gly Ser Pro Val Gly Asn Gln Gly Gln His
        435                 440                 445             
Pro Gly Lys Gly Ser Pro Pro Gly Ser Ser Pro Leu Gln Gly Leu Glu
    450                 455                 460                 
Asn Cys Leu Lys Glu Ile Pro Val Pro Val Leu Arg Pro Ala Trp Pro
465                 470                 475                 480 
Cys Ser Ser Ala Ala Asp Arg Gly Pro Arg Arg Ala Glu Pro Arg Asn
                485                 490                 495     
Trp Thr Ala Asp Lys Glu Gly Ser Ala Pro Lys Pro Ser Pro Leu His
            500                 505                 510         
Cys Leu Glu Ser Ala Leu Arg Gly Ile Leu Pro Val Arg Pro Leu Arg
        515                 520                 525             
Phe Ala Cys Val Gly Gly Pro Ser Pro Ser Pro Ser Pro Gly Ser Ser
    530                 535                 540                 
Ser Ser Phe Ser Gly Ser Glu Gly Glu Asp Pro Arg Pro Glu Pro Glu
545                 550                 555                 560 
Leu Trp Lys Pro Leu Pro Gln Glu Arg Asp Arg Leu Pro Ser Cys Lys
                565                 570                 575     
Pro Pro Val Pro Leu Ser Pro Cys Pro Gly Gly Thr Pro Ala Gly Ser
            580                 585                 590         
Ser Gly Gly Ser Pro Gly Glu Asp Pro Arg Arg Thr Glu Pro Arg Tyr
        595                 600                 605             
Ser Ser Gly Ser Leu Pro Gly Phe Ser Ala Gly Glu Lys Ala Gln Gly
    610                 615                 620                 


<210> 1774
<211> 452
<212> PRT
<213> Homo sapiens

<400> 1774
Val Ser Val Ile Ser Glu Ala Asp Pro Gln Ala Leu Leu Gln Ala Met
 1               5                  10                  15      
Lys Asp Leu Asp Gly Met Asp Ala Asp Ile Leu Gly Leu Lys Lys Ser
            20                  25                  30          
Asn Ser Ala Pro Ser Lys Lys Ala Ala Lys Asp Pro Gly Lys Gly Glu
        35                  40                  45              
Leu Pro Asn His Pro Lys Pro Ala Gly Gly Ala Ile Pro Thr Lys Lys
    50                  55                  60                  
Ser Leu Pro Ser Pro Ser Ser Ser Gly His Gln Asn Arg Arg Phe Ser
65                  70                  75                  80  
Ser Glu Asp Leu Glu Asp Pro Leu Gly Gly Leu Leu Ser Tyr Asp Glu
                85                  90                  95      
Gly Gly Ile Thr Lys Gln Pro Pro Val Thr Gln Ser Lys Thr Ala Ser
            100                 105                 110         
Asp Lys Ser Pro Ser Thr Val Arg Asp Gln Gly Pro Ser Ile Pro Leu
        115                 120                 125             
Thr Pro Gly Asp Thr Pro Ile Arg Lys Lys Glu Glu Leu Leu Phe Asp
    130                 135                 140                 
Asp Gly Asp Asp Ile Met Ala Thr Leu Gly Phe Gly Asp Ser Pro Lys
145                 150                 155                 160 
Ala Glu Lys Arg Gln Ile Gly Asp Gln Glu Gly Pro Arg Pro Ala Arg
                165                 170                 175     
Ser Thr Leu Asp Glu Leu Leu Gly Arg Gly Met Ala Thr Lys Leu Leu
            180                 185                 190         
Ala Arg Pro Gly Thr Gly Glu His Arg Glu Phe Lys Leu Asp Lys Lys
        195                 200                 205             
Tyr Gln Arg Pro Gln Asp Ser Glu Asp Met Trp Gly Asp Glu Asp Phe
    210                 215                 220                 
Thr Phe Gly Ala Tyr Gln Pro Thr Val Val Ser Ser Glu Gly Arg Gln
225                 230                 235                 240 
Ser Arg Arg Gln Ser Val Ser Arg Phe Phe Ala Asp Ser Gly Ala Asp
                245                 250                 255     
Pro Lys Gly Glu Pro Gly Ser Lys Gln Ser Pro Pro Met Ala Ser Ser
            260                 265                 270         
Pro Ile Gln Pro Arg Lys Gly Gly Ala Asp Trp Leu Gly Leu Lys Asp
        275                 280                 285             
Glu Asp Leu Asp Leu Phe Pro Ala Ser Pro Thr Arg Glu Ala His Arg
    290                 295                 300                 
Glu Ser Ser Val Pro Val Thr Pro Ser Val Pro Pro Pro Ala Ser Gln
305                 310                 315                 320 
His Ser Thr Pro Ala Gly Leu Pro Pro Ser Arg Ala Lys Pro Pro Thr
                325                 330                 335     
Glu Gly Ala Gly Ser Pro Ala Lys Ala Ser Gln Ala Ser Lys Leu Arg
            340                 345                 350         
Ala Ser Lys Glu Glu Lys Glu Asp Trp Leu Ser His Ala Leu Ser Arg
        355                 360                 365             
Lys Lys Ser Gln Gly Leu Ala Arg Glu Gln His Ala Gly Thr Ser Glu
    370                 375                 380                 
Gly Leu His Leu Ala Gly Thr Ala Gly His Pro Pro Ser Gly Ser Leu
385                 390                 395                 400 
Thr Trp Ala Phe Cys His Leu His Leu Glu Arg Cys Leu Ser Ser Ala
                405                 410                 415     
Asn Leu Ser Pro Ala His Lys Gly Leu Ser Thr Gln Leu Leu Glu Gly
            420                 425                 430         
Val Leu Glu Gln Leu His Glu Lys Asp Arg Val Ser Gly Leu Val Ser
        435                 440                 445             
Arg Gly Pro Leu
    450         


<210> 1775
<211> 765
<212> PRT
<213> Homo sapiens

<400> 1775
His Ser Lys Ala Phe Ile Val Ala Met Pro Thr Thr Ser Lys Ala Asp
 1               5                  10                  15      
Val Gln Gln Asn Thr Glu Asp Asn Gly Lys Pro Glu Lys Pro Glu Pro
            20                  25                  30          
Ser Ser Pro Ser Pro Arg Ala Pro Ala Ser Ser Gln His Pro Ser Val
        35                  40                  45              
Pro Ala Ser Pro Gln Gly Arg Asn Ala Lys Asp Leu Leu Leu Asp Leu
    50                  55                  60                  
Lys Asn Lys Ile Leu Ala Asn Gly Gly Ala Pro Arg Lys Pro Gln Leu
65                  70                  75                  80  
Arg Ala Lys Lys Ala Glu Glu Leu Asp Leu Gln Ser Thr Glu Ile Thr
                85                  90                  95      
Gly Glu Glu Glu Leu Gly Ser Arg Glu Asp Ser Pro Met Ser Pro Ser
            100                 105                 110         
Asp Thr Gln Asp Gln Lys Arg Thr Leu Arg Pro Pro Ser Arg His Gly
        115                 120                 125             
His Ser Val Val Ala Pro Gly Arg Thr Ala Val Arg Ala Arg Met Pro
    130                 135                 140                 
Ala Leu Pro Arg Arg Glu Gly Val Asp Lys Pro Gly Phe Ser Leu Ala
145                 150                 155                 160 
Thr Gln Pro Arg Pro Gly Ala Pro Pro Ser Ala Ser Ala Ser Pro Ala
                165                 170                 175     
His His Ala Ser Thr Gln Gly Thr Ser His Arg Pro Ser Leu Pro Ala
            180                 185                 190         
Ser Leu Asn Asp Asn Asp Leu Val Asp Ser Asp Glu Asp Glu Arg Ala
        195                 200                 205             
Val Gly Ser Leu His Pro Lys Gly Ala Phe Ala Gln Pro Arg Pro Ala
    210                 215                 220                 
Leu Ser Pro Ser Arg Gln Ser Pro Ser Ser Val Leu Arg Asp Arg Ser
225                 230                 235                 240 
Ser Val His Pro Gly Ala Lys Pro Ala Ser Pro Ala Arg Arg Thr Pro
                245                 250                 255     
His Ser Gly Ala Ala Glu Glu Asp Ser Ser Ala Ser Ala Pro Pro Ser
            260                 265                 270         
Arg Leu Ser Pro Pro His Gly Gly Ser Ser Arg Leu Leu Pro Thr Gln
        275                 280                 285             
Pro His Leu Ser Ser Pro Leu Ser Lys Gly Gly Lys Asp Gly Glu Asp
    290                 295                 300                 
Ala Pro Ala Thr Asn Ser Asn Ala Pro Ser Arg Ser Thr Met Ser Ser
305                 310                 315                 320 
Ser Val Ser Ser His Leu Ser Ser Arg Thr Gln Val Ser Glu Gly Ala
                325                 330                 335     
Glu Ala Ser Asp Gly Glu Ser His Gly Asp Gly Asp Arg Glu Asp Gly
            340                 345                 350         
Gly Arg Gln Ala Glu Ala Thr Ala Gln Thr Leu Arg Ala Arg Pro Ala
        355                 360                 365             
Ser Gly His Phe His Leu Leu Arg His Lys Pro Phe Ala Ala Asn Gly
    370                 375                 380                 
Arg Ser Pro Ser Arg Phe Ser Ile Gly Arg Gly Pro Arg Leu Gln Pro
385                 390                 395                 400 
Ser Ser Ser Pro Gln Ser Thr Val Pro Ser Arg Ala His Pro Arg Val
                405                 410                 415     
Pro Ser His Ser Asp Ser His Pro Lys Leu Ser Ser Gly Ile His Gly
            420                 425                 430         
Asp Glu Glu Asp Glu Lys Pro Leu Pro Ala Thr Val Val Asn Asp His
        435                 440                 445             
Val Pro Ser Ser Ser Arg Gln Pro Ile Ser Arg Gly Trp Glu Asp Leu
    450                 455                 460                 
Arg Arg Ser Pro Gln Arg Gly Ala Ser Leu His Arg Lys Glu Pro Ile
465                 470                 475                 480 
Pro Glu Asn Pro Lys Ser Thr Gly Ala Asp Thr His Pro Gln Gly Lys
                485                 490                 495     
Tyr Ser Ser Leu Ala Ser Lys Ala Gln Asp Val Gln Gln Ser Thr Asp
            500                 505                 510         
Ala Asp Thr Glu Gly His Ser Pro Lys Ala Gln Pro Gly Ser Thr Asp
        515                 520                 525             
Arg His Ala Ser Pro Ala Arg Pro Pro Ala Ala Arg Ser Gln Gln His
    530                 535                 540                 
Pro Ser Val Pro Arg Arg Met Thr Pro Gly Arg Ala Pro Glu Gln Gln
545                 550                 555                 560 
Pro Pro Pro Pro Val Ala Thr Ser Gln His His Pro Gly Pro Gln Ser
                565                 570                 575     
Arg Asp Ala Gly Arg Ser Pro Ser Gln Pro Arg Leu Ser Leu Thr Gln
            580                 585                 590         
Ala Gly Arg Pro Arg Pro Thr Ser Gln Gly Arg Ser His Ser Ser Ser
        595                 600                 605             
Asp Pro Tyr Thr Ala Ser Ser Arg Gly Met Leu Pro Thr Ala Leu Gln
    610                 615                 620                 
Asn Gln Asp Glu Asp Ala Gln Gly Ser Tyr Asp Asp Asp Ser Thr Glu
625                 630                 635                 640 
Val Glu Ala Gln Asp Val Arg Ala Pro Ala His Ala Ala Arg Ala Lys
                645                 650                 655     
Glu Ala Ala Ala Ser Leu Pro Lys His Gln Gln Gly Arg Gln Arg Arg
            660                 665                 670         
Arg Trp Glu Pro Arg Gln Gly Arg Glu Gly Ala Cys His Arg Ala Cys
        675                 680                 685             
Pro Ser Arg Arg Glu Pro Gly Ser Cys Glu Ala Thr Ser Pro Pro Thr
    690                 695                 700                 
Ser Arg Gln Leu Pro Gln Gly Leu Pro Arg Pro Phe Pro Thr Ala Ala
705                 710                 715                 720 
Ser Gln Arg Cys His Arg Glu Pro Arg Arg Gly His Pro Pro Leu Ala
                725                 730                 735     
Ala Val His His Ala Arg Pro Ala Trp Pro Leu Leu His His Pro Asp
            740                 745                 750         
Ala Val Leu Ala Pro Glu Asp Asp Ala Cys Gln Ile Pro
        755                 760                 765 


<210> 1776
<211> 832
<212> PRT
<213> Homo sapiens

<400> 1776
Gly Gly His Pro Gly Met Pro Gly Gly Met Gly Thr Pro Gly Glu Pro
 1               5                  10                  15      
Gly Pro Gln Gly Pro Pro Gly Ser Arg Gly Pro Pro Gly Met Arg Gly
            20                  25                  30          
Ala Lys Gly Arg Arg Gly Pro Arg Gly Pro Asp Gly Pro Ala Gly Glu
        35                  40                  45              
Gln Gly Ser Arg Gly Leu Lys Gly Pro Pro Gly Pro Gln Gly Arg Pro
    50                  55                  60                  
Gly Arg Pro Gly Gln Gln Gly Val Ala Gly Glu Arg Gly His Leu Gly
65                  70                  75                  80  
Ser Arg Gly Phe Pro Gly Ile Pro Gly Pro Ser Gly Pro Pro Gly Thr
                85                  90                  95      
Lys Gly Leu Pro Gly Glu Pro Gly Pro Gln Gly Pro Gln Gly Pro Ile
            100                 105                 110         
Gly Pro Pro Gly Glu Met Gly Pro Lys Gly Pro Pro Gly Ala Val Gly
        115                 120                 125             
Glu Pro Gly Leu Pro Gly Glu Ala Gly Met Lys Gly Asp Leu Gly Pro
    130                 135                 140                 
Leu Gly Thr Pro Gly Glu Gln Gly Leu Ile Gly Gln Arg Gly Glu Pro
145                 150                 155                 160 
Gly Leu Glu Gly Asp Ser Gly Pro Met Gly Pro Asp Gly Leu Lys Gly
                165                 170                 175     
Asp Arg Gly Asp Pro Gly Pro Asp Gly Glu His Gly Glu Lys Gly Gln
            180                 185                 190         
Glu Gly Leu Met Gly Glu Asp Gly Pro Pro Gly Pro Pro Gly Val Thr
        195                 200                 205             
Gly Val Arg Gly Pro Glu Gly Lys Ser Gly Lys Gln Gly Glu Lys Gly
    210                 215                 220                 
Arg Thr Gly Ala Lys Gly Ala Lys Gly Tyr Gln Gly Gln Leu Gly Glu
225                 230                 235                 240 
Met Gly Val Pro Gly Asp Pro Gly Pro Pro Gly Thr Pro Gly Pro Lys
                245                 250                 255     
Gly Ser Arg Gly Ser Leu Gly Pro Thr Gly Ala Pro Gly Arg Met Gly
            260                 265                 270         
Ala Gln Gly Glu Pro Gly Leu Ala Gly Tyr Asp Gly His Lys Gly Ile
        275                 280                 285             
Val Gly Pro Leu Gly Pro Pro Gly Pro Lys Gly Glu Lys Gly Glu Gln
    290                 295                 300                 
Gly Glu Asp Gly Lys Ala Glu Gly Pro Pro Gly Pro Pro Gly Asp Arg
305                 310                 315                 320 
Gly Pro Val Gly Asp Arg Gly Asp Arg Gly Glu Pro Gly Asp Pro Gly
                325                 330                 335     
Tyr Pro Gly Gln Glu Gly Val Gln Gly Leu Arg Gly Lys Pro Gly Gln
            340                 345                 350         
Gln Gly Gln Pro Gly His Pro Gly Pro Arg Gly Trp Pro Gly Pro Lys
        355                 360                 365             
Gly Ser Lys Gly Ala Glu Gly Pro Lys Gly Lys Gln Gly Lys Ala Gly
    370                 375                 380                 
Ala Pro Gly Arg Arg Gly Val Gln Gly Leu Gln Gly Leu Pro Gly Pro
385                 390                 395                 400 
Arg Gly Val Val Gly Arg Gln Gly Leu Glu Gly Ile Ala Gly Pro Asp
                405                 410                 415     
Gly Leu Pro Gly Arg Asp Gly Gln Ala Gly Gln Gln Gly Glu Gln Gly
            420                 425                 430         
Asp Asp Gly Asp Pro Gly Pro Met Gly Pro Ala Gly Lys Arg Gly Asn
        435                 440                 445             
Pro Gly Val Ala Gly Leu Pro Gly Ala Gln Gly Pro Pro Gly Phe Lys
    450                 455                 460                 
Gly Glu Ser Gly Leu Pro Gly Gln Leu Gly Pro Pro Gly Lys Arg Gly
465                 470                 475                 480 
Thr Glu Gly Arg Thr Gly Leu Pro Gly Asn Gln Gly Glu Pro Gly Ser
                485                 490                 495     
Lys Gly Gln Pro Gly Asp Ser Gly Glu Met Gly Phe Pro Gly Met Ala
            500                 505                 510         
Gly Leu Phe Gly Pro Lys Gly Pro Pro Gly Asp Ile Gly Phe Lys Gly
        515                 520                 525             
Ile Gln Gly Pro Arg Gly Pro Pro Gly Leu Met Gly Lys Glu Gly Ile
    530                 535                 540                 
Val Gly Pro Leu Gly Ile Leu Gly Pro Ser Gly Leu Pro Gly Pro Lys
545                 550                 555                 560 
Gly Asp Lys Gly Ser Arg Gly Asp Trp Gly Leu Gln Gly Pro Arg Gly
                565                 570                 575     
Pro Pro Gly Pro Arg Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Gly
            580                 585                 590         
Pro Ile Gln Leu Gln Gln Asp Asp Leu Gly Ala Ala Phe Gln Thr Trp
        595                 600                 605             
Met Asp Thr Ser Gly Ala Leu Arg Pro Glu Ser Tyr Ser Tyr Pro Asp
    610                 615                 620                 
Arg Leu Val Leu Asp Gln Gly Gly Glu Ile Phe Lys Thr Leu His Tyr
625                 630                 635                 640 
Leu Ser Asn Leu Ile Gln Ser Ile Lys Thr Pro Leu Gly Thr Lys Glu
                645                 650                 655     
Asn Pro Ala Arg Val Cys Arg Asp Leu Met Asp Cys Glu Gln Lys Met
            660                 665                 670         
Val Asp Gly Thr Tyr Trp Val Asp Pro Asn Leu Gly Cys Ser Ser Asp
        675                 680                 685             
Thr Ile Glu Val Ser Cys Asn Phe Thr His Gly Gly Gln Thr Cys Leu
    690                 695                 700                 
Lys Pro Ile Thr Ala Ser Lys Val Glu Phe Ala Ile Ser Arg Val Gln
705                 710                 715                 720 
Met Asn Phe Leu His Leu Leu Ser Ser Glu Val Thr Gln His Ile Thr
                725                 730                 735     
Ile His Cys Leu Asn Met Thr Val Trp Gln Glu Gly Thr Gly Gln Thr
            740                 745                 750         
Pro Ala Lys Gln Ala Val Arg Phe Arg Ala Trp Asn Gly Gln Ile Phe
        755                 760                 765             
Glu Ala Gly Gly Gln Phe Arg Pro Glu Val Ser Met Asp Gly Cys Lys
    770                 775                 780                 
Val Gln Asp Gly Arg Trp His Gln Thr Leu Phe Thr Phe Arg Thr Gln
785                 790                 795                 800 
Asp Pro Gln Gln Leu Pro Ile Ile Ser Val Asp Asn Leu Pro Pro Ala
                805                 810                 815     
Ser Ser Gly Lys Gln Tyr Arg Leu Glu Val Gly Pro Ala Cys Phe Leu
            820                 825                 830         


<210> 1777
<211> 534
<212> PRT
<213> Homo sapiens

<400> 1777
Pro Gln Arg Pro Ala Met Lys Pro His Leu Lys Gln Trp Arg Gln Arg
 1               5                  10                  15      
Met Leu Phe Gly Ile Phe Ala Trp Gly Leu Leu Phe Leu Leu Ile Phe
            20                  25                  30          
Ile Tyr Phe Thr Asp Ser Asn Pro Ala Glu Pro Val Pro Ser Ser Leu
        35                  40                  45              
Ser Phe Leu Glu Thr Arg Arg Leu Leu Pro Val Gln Gly Lys Gln Arg
    50                  55                  60                  
Ala Ile Met Gly Ala Ala His Glu Pro Ser Pro Pro Gly Gly Leu Asp
65                  70                  75                  80  
Ala Arg Gln Ala Leu Pro Arg Ala His Pro Ala Gly Ser Phe His Ala
                85                  90                  95      
Gly Pro Gly Asp Leu Gln Lys Trp Ala Gln Ser Gln Asp Gly Phe Glu
            100                 105                 110         
His Lys Glu Phe Phe Ser Ser Gln Val Gly Arg Lys Ser Gln Ser Ala
        115                 120                 125             
Phe Tyr Pro Glu Asp Asp Asp Tyr Phe Phe Ala Ala Gly Gln Pro Gly
    130                 135                 140                 
Trp His Ser His Thr Gln Gly Thr Leu Gly Phe Pro Ser Pro Gly Glu
145                 150                 155                 160 
Pro Gly Pro Arg Glu Gly Ala Phe Pro Ala Ala Gln Val Gln Arg Arg
                165                 170                 175     
Arg Val Lys Lys Arg His Arg Arg Gln Arg Arg Ser His Val Leu Glu
            180                 185                 190         
Glu Gly Asp Asp Gly Asp Arg Leu Tyr Ser Ser Met Ser Arg Ala Phe
        195                 200                 205             
Leu Tyr Arg Leu Trp Lys Gly Asn Val Ser Ser Lys Met Leu Asn Pro
    210                 215                 220                 
Arg Leu Gln Lys Ala Met Lys Asp Tyr Leu Thr Ala Asn Lys His Gly
225                 230                 235                 240 
Val Arg Phe Arg Gly Lys Arg Glu Ala Gly Leu Ser Arg Ala Gln Leu
                245                 250                 255     
Leu Cys Gln Leu Arg Ser Arg Ala Arg Val Arg Thr Leu Asp Gly Thr
            260                 265                 270         
Glu Ala Pro Phe Ser Ala Leu Gly Trp Arg Arg Leu Val Pro Ala Val
        275                 280                 285             
Pro Leu Ser Gln Leu His Pro Arg Gly Leu Arg Ser Cys Ala Val Val
    290                 295                 300                 
Met Ser Ala Gly Ala Ile Leu Asn Ser Ser Leu Gly Glu Glu Ile Asp
305                 310                 315                 320 
Ser His Asp Ala Val Leu Arg Phe Asn Ser Ala Pro Thr Arg Gly Tyr
                325                 330                 335     
Glu Lys Asp Val Gly Asn Lys Thr Thr Ile Arg Ile Ile Asn Ser Gln
            340                 345                 350         
Ile Leu Thr Asn Pro Ser His His Phe Ile Asp Ser Ser Leu Tyr Lys
        355                 360                 365             
Asp Val Ile Leu Val Ala Trp Asp Pro Ala Pro Tyr Ser Ala Asn Leu
    370                 375                 380                 
Asn Leu Trp Tyr Lys Lys Pro Asp Tyr Asn Leu Phe Thr Pro Tyr Ile
385                 390                 395                 400 
Gln His Arg Gln Arg Asn Pro Asn Gln Pro Phe Tyr Ile Leu His Pro
                405                 410                 415     
Lys Phe Ile Trp Gln Leu Trp Asp Ile Ile Gln Glu Asn Thr Lys Glu
            420                 425                 430         
Lys Ile Gln Pro Asn Pro Pro Ser Ser Gly Phe Ile Gly Ile Leu Ile
        435                 440                 445             
Met Met Ser Met Cys Arg Glu Val His Val Tyr Glu Tyr Ile Pro Ser
    450                 455                 460                 
Val Arg Gln Thr Glu Leu Cys His Tyr His Glu Leu Tyr Tyr Asp Ala
465                 470                 475                 480 
Ala Cys Thr Leu Gly Ala Tyr His Pro Leu Leu Tyr Glu Lys Leu Leu
                485                 490                 495     
Val Gln Arg Leu Asn Met Gly Thr Gln Gly Asp Leu His Arg Lys Gly
            500                 505                 510         
Lys Val Val Leu Pro Gly Phe Gln Ala Val His Cys Pro Ala Pro Ser
        515                 520                 525             
Pro Val Ile Pro His Ser
    530                 


<210> 1778
<211> 46
<212> PRT
<213> Homo sapiens

<400> 1778
Gln Leu Phe Ser Glu Ala Val Ala Pro Ala Ile Glu Lys Asp Phe Lys
 1               5                  10                  15      
Asp Gly Thr Phe Asp Pro Asp Asn Leu Glu Lys Tyr Gly Phe Glu Pro
            20                  25                  30          
Thr Gln Glu Gly Lys Leu Phe Gln Leu Tyr Pro Arg Asn Phe
        35                  40                  45      


<210> 1779
<211> 32
<212> PRT
<213> Homo sapiens

<400> 1779
Ser Asn Ala Lys Glu Pro Lys Thr Arg Ala Gly Gly Phe Ala Ser Ala
 1               5                  10                  15      
Leu Glu Arg His Ser Glu Leu Leu Gln Lys Val Glu Pro Leu Gln Lys
            20                  25                  30          


<210> 1780
<211> 34
<212> PRT
<213> Homo sapiens

<400> 1780
Ile Lys Val Gln Glu Lys Tyr Val Trp Asn Lys Arg Glu Ser Thr Glu
 1               5                  10                  15      
Lys Gly Ser Pro Leu Gly Glu Val Val Glu Gln Gly Ile Thr Arg Val
            20                  25                  30          
Arg Asn
        


<210> 1781
<211> 355
<212> PRT
<213> Homo sapiens

<400> 1781
Met Ala Glu Val His Arg Arg Gln His Ala Arg Val Lys Gly Glu Ala
 1               5                  10                  15      
Pro Ala Lys Ser Ser Thr Leu Arg Asp Glu Glu Glu Leu Gly Met Ala
            20                  25                  30          
Ser Ala Glu Thr Leu Thr Val Phe Leu Lys Leu Leu Ala Ala Gly Phe
        35                  40                  45              
Tyr Gly Val Ser Ser Phe Leu Ile Val Val Val Asn Lys Ser Val Leu
    50                  55                  60                  
Thr Asn Tyr Arg Phe Pro Ser Ser Leu Cys Val Gly Leu Gly Gln Met
65                  70                  75                  80  
Val Ala Thr Val Ala Val Leu Trp Val Gly Lys Ala Leu Arg Val Val
                85                  90                  95      
Lys Phe Pro Asp Leu Asp Arg Asn Val Pro Arg Lys Thr Phe Pro Leu
            100                 105                 110         
Pro Leu Leu Tyr Phe Gly Asn Gln Ile Thr Gly Leu Phe Ser Thr Lys
        115                 120                 125             
Lys Leu Asn Leu Pro Met Phe Thr Val Leu Arg Arg Phe Ser Ile Leu
    130                 135                 140                 
Phe Thr Met Phe Ala Glu Gly Val Leu Leu Lys Lys Thr Phe Ser Trp
145                 150                 155                 160 
Gly Ile Lys Met Thr Val Phe Ala Met Ile Ile Gly Ala Phe Val Ala
                165                 170                 175     
Ala Ser Ser Asp Leu Ala Phe Asp Leu Glu Gly Tyr Ala Phe Ile Leu
            180                 185                 190         
Ile Asn Asp Val Leu Thr Ala Ala Asn Gly Ala Tyr Val Lys Gln Lys
        195                 200                 205             
Leu Asp Ser Lys Glu Leu Gly Lys Tyr Gly Leu Leu Tyr Tyr Asn Ala
    210                 215                 220                 
Leu Phe Met Ile Leu Pro Thr Leu Ala Ile Ala Tyr Phe Thr Gly Asp
225                 230                 235                 240 
Ala Gln Lys Ala Val Glu Phe Glu Gly Trp Ala Asp Thr Leu Phe Leu
                245                 250                 255     
Leu Gln Phe Thr Leu Ser Cys Val Met Gly Phe Ile Leu Met Tyr Ala
            260                 265                 270         
Thr Val Leu Cys Thr Gln Tyr Asn Ser Ala Leu Thr Thr Thr Ile Val
        275                 280                 285             
Gly Cys Ile Lys Asn Ile Leu Ile Thr Tyr Ile Gly Met Val Phe Gly
    290                 295                 300                 
Gly Asp Tyr Ile Phe Thr Trp Thr Asn Phe Ile Gly Leu Asn Ile Ser
305                 310                 315                 320 
Ile Ala Gly Ser Leu Val Tyr Ser Tyr Ile Thr Phe Thr Glu Glu Gln
                325                 330                 335     
Leu Ser Lys Gln Ser Glu Ala Asn Asn Lys Leu Asp Ile Lys Gly Lys
            340                 345                 350         
Gly Ala Val
        355 


<210> 1782
<211> 173
<212> PRT
<213> Homo sapiens

<400> 1782
Met Pro Met Lys Gly Arg Phe Pro Ile Arg Arg Thr Leu Gln Tyr Leu
 1               5                  10                  15      
Ser Gln Gly Asn Val Val Phe Lys Asp Ser Val Lys Val Met Thr Val
            20                  25                  30          
Asn Tyr Asn Thr His Gly Glu Leu Gly Glu Gly Ala Arg Lys Phe Val
        35                  40                  45              
Phe Phe Asn Ile Pro Gln Ile Gln Tyr Lys Asn Pro Trp Val Gln Ile
    50                  55                  60                  
Met Met Phe Lys Asn Met Thr Pro Ser Pro Phe Leu Arg Phe Tyr Leu
65                  70                  75                  80  
Asp Ser Gly Glu Gln Val Leu Val Asp Val Glu Thr Lys Ser Asn Lys
                85                  90                  95      
Glu Ile Met Glu His Ile Arg Lys Ile Leu Gly Lys Asn Glu Glu Thr
            100                 105                 110         
Leu Arg Glu Glu Glu Glu Glu Lys Lys Gln Leu Ser His Pro Ala Asn
        115                 120                 125             
Phe Gly Pro Arg Lys Tyr Cys Leu Arg Glu Cys Ile Cys Glu Val Glu
    130                 135                 140                 
Gly Gln Val Pro Cys Pro Ser Leu Val Pro Leu Pro Lys Glu Met Arg
145                 150                 155                 160 
Gly Lys Tyr Lys Ala Ala Leu Lys Ala Asp Ala Gln Asp
                165                 170             


<210> 1783
<211> 260
<212> PRT
<213> Homo sapiens

<400> 1783
Leu Pro Ser Pro Pro Arg Ala Arg Ser Gly Val Phe Cys Pro Thr Ser
 1               5                  10                  15      
Gly Ala Gly Ser Gly Ile Gly Arg Ala Val Ser Val Arg Leu Ala Gly
            20                  25                  30          
Glu Gly Ala Thr Val Ala Ala Cys Asp Leu Asp Arg Ala Ala Ala Gln
        35                  40                  45              
Glu Thr Val Arg Leu Leu Gly Gly Pro Gly Ser Lys Glu Gly Pro Pro
    50                  55                  60                  
Arg Gly Asn His Ala Ala Phe Gln Ala Asp Val Ser Glu Ala Arg Ala
65                  70                  75                  80  
Ala Arg Cys Leu Leu Glu Gln Val Gln Ala Cys Phe Ser Arg Pro Pro
                85                  90                  95      
Ser Val Val Val Ser Cys Ala Gly Ile Thr Gln Asp Glu Phe Leu Leu
            100                 105                 110         
His Met Ser Glu Asp Asp Trp Asp Lys Val Ile Ala Val Asn Leu Lys
        115                 120                 125             
Gly Thr Phe Leu Val Thr Gln Ala Ala Ala Gln Ala Leu Val Ser Asn
    130                 135                 140                 
Gly Cys Arg Gly Ser Ile Ile Asn Ile Ser Ser Ile Val Gly Lys Val
145                 150                 155                 160 
Gly Asn Val Gly Gln Thr Asn Tyr Ala Ala Ser Lys Ala Gly Val Ile
                165                 170                 175     
Gly Leu Thr Gln Thr Ala Ala Arg Glu Leu Gly Arg His Gly Ile Arg
            180                 185                 190         
Cys Asn Ser Val Leu Pro Gly Phe Ile Ala Thr Pro Met Thr Gln Lys
        195                 200                 205             
Val Pro Gln Lys Val Val Asp Lys Ile Thr Glu Met Ile Pro Met Gly
    210                 215                 220                 
His Leu Gly Asp Pro Glu Asp Val Ala Asp Val Val Ala Phe Leu Ala
225                 230                 235                 240 
Ser Glu Asp Ser Gly Tyr Ile Thr Gly Thr Ser Val Glu Val Thr Gly
                245                 250                 255     
Gly Leu Phe Met
            260 


<210> 1784
<211> 322
<212> PRT
<213> Homo sapiens

<400> 1784
Met Glu Gly Ile Ser Asn Phe Lys Thr Pro Ser Lys Leu Ser Glu Lys
 1               5                  10                  15      
Lys Lys Ser Val Leu Cys Ser Thr Pro Thr Ile Asn Ile Pro Ala Ser
            20                  25                  30          
Pro Phe Met Gln Lys Leu Gly Phe Gly Thr Gly Val Asn Val Tyr Leu
        35                  40                  45              
Met Lys Arg Ser Pro Arg Gly Leu Ser His Ser Pro Trp Ala Val Lys
    50                  55                  60                  
Lys Ile Asn Pro Ile Cys Asn Asp His Tyr Arg Ser Val Tyr Gln Lys
65                  70                  75                  80  
Arg Leu Met Asp Glu Ala Lys Ile Leu Lys Ser Leu His His Pro Asn
                85                  90                  95      
Ile Val Gly Tyr Arg Ala Phe Thr Glu Ala Ser Asp Gly Ser Leu Cys
            100                 105                 110         
Leu Ala Met Glu Tyr Gly Gly Glu Lys Ser Leu Asn Asp Leu Ile Glu
        115                 120                 125             
Glu Arg Tyr Lys Ala Ser Gln Asp Pro Phe Pro Ala Ala Ile Ile Leu
    130                 135                 140                 
Lys Val Ala Leu Asn Met Ala Arg Gly Leu Lys Tyr Leu His Gln Glu
145                 150                 155                 160 
Lys Lys Leu Leu His Gly Asp Ile Glu Ser Ser Asn Val Val Ile Lys
                165                 170                 175     
Gly Asp Phe Glu Thr Ile Lys Ile Cys Asp Val Gly Val Ser Leu Pro
            180                 185                 190         
Leu Asp Glu Asn Met Thr Val Thr Asp Pro Glu Ala Cys Tyr Ile Gly
        195                 200                 205             
Thr Glu Pro Trp Lys Pro Lys Glu Ala Val Glu Glu Asn Gly Val Ile
    210                 215                 220                 
Thr Asp Lys Ala Asp Ile Phe Ala Phe Gly Leu Thr Leu Trp Glu Met
225                 230                 235                 240 
Met Thr Leu Ser Ile Pro His Ile Asn Leu Ser Asn Asp Asn Asp Asp
                245                 250                 255     
Glu Asp Lys Thr Phe Asp Glu Ser Asp Phe Asp Asp Glu Ala Tyr Tyr
            260                 265                 270         
Ala Ala Leu Gly Thr Arg Pro Pro Ile Asn Met Glu Glu Leu Asp Glu
        275                 280                 285             
Ser Tyr Gln Lys Val Ile Glu Leu Phe Ser Val Cys Thr Asn Glu Asp
    290                 295                 300                 
Pro Lys Asp Arg Pro Ser Ala Ala His Ile Val Glu Ala Leu Glu Thr
305                 310                 315                 320 
Asp Val
        


<210> 1785
<211> 212
<212> PRT
<213> Homo sapiens

<400> 1785
Met Ser Leu Leu Arg Gln Lys Ile Ala Gln Leu Glu Glu Glu Lys Gln
 1               5                  10                  15      
Ala Arg Thr Ala Leu Val Val Glu Arg Asp Asn Ala His Leu Thr Ile
            20                  25                  30          
Arg Asn Leu Gln Lys Lys Val Glu Arg Leu Gln Lys Glu Leu Asn Thr
        35                  40                  45              
Cys Arg Asp Leu His Thr Glu Leu Lys Ala Lys Leu Ala Asp Thr Asn
    50                  55                  60                  
Glu Leu Lys Ile Lys Thr Leu Glu Gln Thr Lys Ala Ile Glu Asp Leu
65                  70                  75                  80  
Asn Lys Ser Arg Asp Gln Leu Glu Lys Met Lys Glu Lys Ala Glu Lys
                85                  90                  95      
Lys Leu Met Ser Ile Lys Ser Glu Leu Asp Thr Thr Glu His Glu Ala
            100                 105                 110         
Lys Glu Asn Lys Glu Arg Ala Arg Asn Met Ile Glu Val Val Thr Ser
        115                 120                 125             
Glu Met Lys Thr Leu Lys Lys Ser Leu Glu Glu Ala Glu Lys Arg Glu
    130                 135                 140                 
Lys Gln Leu Ala Asp Phe Arg Glu Val Val Ser Gln Met Leu Gly Leu
145                 150                 155                 160 
Asn Val Thr Ser Leu Ala Leu Pro Asp Tyr Glu Ile Ile Lys Cys Leu
                165                 170                 175     
Glu Arg Leu Ile His Ser His Gln His His Phe Val Thr Cys Ala Cys
            180                 185                 190         
Leu Lys Asp Val Thr Thr Gly Gln Glu Arg His Pro Gln Gly His Leu
        195                 200                 205             
Gln Leu Leu His
    210         


<210> 1786
<211> 674
<212> PRT
<213> Homo sapiens

<400> 1786
Met Leu Lys Asn Lys Ala Lys Arg Ser Leu Thr Glu Ser Leu Glu Ser
 1               5                  10                  15      
Ile Leu Ser Arg Gly Asn Lys Ala Arg Gly Leu Gln Glu His Ser Ile
            20                  25                  30          
Ser Val Asp Leu Asp Ser Ser Leu Ser Ser Thr Leu Ser Asn Thr Ser
        35                  40                  45              
Lys Glu Pro Ser Val Cys Glu Lys Glu Ala Leu Pro Ile Ser Glu Ser
    50                  55                  60                  
Ser Phe Lys Leu Leu Gly Ser Ser Glu Asp Leu Ser Ser Asp Ser Glu
65                  70                  75                  80  
Ser His Leu Pro Glu Glu Pro Ala Pro Leu Ser Pro Gln Gln Ala Phe
                85                  90                  95      
Arg Arg Arg Ala Asn Thr Leu Ser His Phe Pro Ile Glu Cys Gln Glu
            100                 105                 110         
Pro Pro Gln Pro Ala Arg Gly Ser Pro Gly Val Ser Gln Arg Lys Leu
        115                 120                 125             
Met Arg Tyr His Ser Val Ser Thr Glu Thr Pro His Glu Arg Lys Asp
    130                 135                 140                 
Phe Glu Ser Lys Ala Asn His Leu Gly Asp Ser Gly Gly Thr Pro Val
145                 150                 155                 160 
Lys Thr Arg Arg His Ser Trp Arg Gln Gln Ile Phe Leu Arg Val Ala
                165                 170                 175     
Thr Pro Gln Lys Ala Cys Asp Ser Ser Ser Arg Tyr Glu Asp Tyr Ser
            180                 185                 190         
Glu Leu Gly Glu Leu Pro Pro Arg Ser Pro Leu Glu Pro Val Cys Glu
        195                 200                 205             
Asp Gly Pro Phe Gly Pro Pro Pro Glu Glu Lys Lys Arg Thr Ser Arg
    210                 215                 220                 
Glu Leu Arg Glu Leu Trp Gln Lys Ala Ile Leu Gln Gln Ile Leu Leu
225                 230                 235                 240 
Leu Arg Met Glu Lys Glu Asn Gln Lys Leu Gln Ala Ser Glu Asn Asp
                245                 250                 255     
Leu Leu Asn Lys Arg Leu Lys Leu Asp Tyr Glu Glu Ile Thr Pro Cys
            260                 265                 270         
Leu Lys Glu Val Thr Thr Val Trp Glu Lys Met Leu Ser Thr Pro Gly
        275                 280                 285             
Arg Ser Lys Ile Lys Phe Asp Met Glu Lys Met His Ser Ala Val Gly
    290                 295                 300                 
Gln Gly Val Pro Arg His His Arg Gly Glu Ile Trp Lys Phe Leu Ala
305                 310                 315                 320 
Glu Gln Phe His Leu Lys His Gln Phe Pro Ser Lys Gln Gln Pro Lys
                325                 330                 335     
Asp Val Pro Tyr Lys Glu Leu Leu Lys Gln Leu Thr Ser Gln Gln His
            340                 345                 350         
Ala Ile Leu Ile Asp Leu Gly Arg Thr Phe Pro Thr His Pro Tyr Phe
        355                 360                 365             
Ser Ala Gln Leu Gly Ala Gly Gln Leu Ser Leu Tyr Asn Ile Leu Lys
    370                 375                 380                 
Ala Tyr Ser Leu Leu Asp Gln Glu Val Gly Tyr Cys Gln Gly Leu Ser
385                 390                 395                 400 
Phe Val Ala Gly Ile Leu Leu Leu His Met Ser Glu Glu Glu Ala Phe
                405                 410                 415     
Lys Met Leu Lys Phe Leu Met Phe Asp Met Gly Leu Arg Lys Gln Tyr
            420                 425                 430         
Arg Pro Asp Met Ile Ile Leu Gln Ile Gln Met Tyr Gln Leu Ser Arg
        435                 440                 445             
Leu Leu His Asp Tyr His Arg Asp Leu Tyr Asn His Leu Glu Glu His
    450                 455                 460                 
Glu Ile Gly Pro Ser Leu Tyr Ala Ala Pro Trp Phe Leu Thr Met Phe
465                 470                 475                 480 
Ala Ser Gln Phe Pro Leu Gly Phe Val Ala Arg Val Phe Asp Met Ile
                485                 490                 495     
Phe Leu Gln Gly Thr Glu Val Ile Phe Lys Val Ala Leu Ser Leu Leu
            500                 505                 510         
Gly Ser His Lys Pro Leu Ile Leu Gln His Glu Asn Leu Glu Thr Ile
        515                 520                 525             
Val Asp Phe Ile Lys Ser Thr Leu Pro Asn Leu Gly Leu Val Gln Met
    530                 535                 540                 
Glu Lys Thr Ile Asn Gln Val Phe Glu Met Asp Ile Ala Lys Gln Leu
545                 550                 555                 560 
Gln Ala Tyr Glu Val Glu Tyr His Val Leu Gln Glu Glu Leu Ile Asp
                565                 570                 575     
Ser Ser Pro Leu Ser Asp Asn Gln Arg Met Asp Lys Leu Glu Lys Thr
            580                 585                 590         
Asn Ser Ser Leu Arg Lys Gln Asn Leu Asp Leu Leu Glu Gln Leu Gln
        595                 600                 605             
Val Ala Asn Gly Arg Ile Gln Ser Leu Glu Ala Thr Ile Glu Lys Leu
    610                 615                 620                 
Leu Ser Ser Glu Ser Lys Leu Lys Gln Ala Met Leu Thr Leu Glu Leu
625                 630                 635                 640 
Glu Arg Ser Ala Leu Leu Gln Thr Val Glu Glu Leu Arg Arg Arg Ser
                645                 650                 655     
Ala Glu Pro Ser Asp Arg Glu Pro Glu Cys Thr Gln Pro Glu Pro Thr
            660                 665                 670         
Gly Asp
        


<210> 1787
<211> 585
<212> PRT
<213> Homo sapiens

<400> 1787
Met Ala Pro Ser Thr Pro Leu Leu Thr Val Arg Gly Ser Glu Gly Leu
 1               5                  10                  15      
Tyr Met Val Asn Gly Pro Pro His Phe Thr Glu Ser Thr Val Phe Pro
            20                  25                  30          
Arg Glu Ser Gly Lys Asn Cys Lys Val Cys Ile Phe Ser Lys Asp Gly
        35                  40                  45              
Thr Leu Phe Ala Trp Gly Asn Gly Glu Lys Val Asn Ile Ile Ser Val
    50                  55                  60                  
Thr Asn Lys Gly Leu Leu His Ser Phe Asp Leu Leu Lys Ala Val Cys
65                  70                  75                  80  
Leu Glu Phe Pro Pro Lys Asn Thr Val Leu Ala Thr Trp Gln Pro Tyr
                85                  90                  95      
Ser Thr Ser Lys Asp Gly Thr Ala Gly Ile Pro Asn Leu Gln Leu Tyr
            100                 105                 110         
Asp Val Lys Thr Gly Thr Cys Leu Lys Ser Phe Ile Gln Lys Lys Met
        115                 120                 125             
Gln Asn Trp Cys Pro Ser Trp Ser Glu Asp Glu Thr Leu Cys Ala Arg
    130                 135                 140                 
Asn Val Asn Asn Glu Val His Phe Phe Glu Asn Asn Asn Phe Asn Thr
145                 150                 155                 160 
Ile Ala Asn Lys Leu His Leu Gln Lys Ile Asn Asp Phe Val Leu Ser
                165                 170                 175     
Pro Gly Pro Gln Pro Tyr Lys Val Ala Val Tyr Val Pro Gly Ser Lys
            180                 185                 190         
Gly Ala Pro Ser Phe Val Arg Leu Tyr Gln Tyr Pro Asn Phe Ala Gly
        195                 200                 205             
Pro His Ala Ala Leu Ala Asn Lys Ser Phe Phe Lys Ala Asp Lys Val
    210                 215                 220                 
Thr Met Leu Trp Asn Lys Lys Ala Thr Ala Val Leu Val Ile Ala Ser
225                 230                 235                 240 
Thr Asp Val Asp Lys Thr Gly Ala Ser Tyr Tyr Gly Glu Gln Thr Leu
                245                 250                 255     
His Tyr Ile Ala Thr Asn Gly Glu Ser Ala Val Val Gln Leu Pro Lys
            260                 265                 270         
Asn Gly Pro Ile Tyr Asp Val Val Trp Asn Ser Ser Ser Thr Glu Phe
        275                 280                 285             
Cys Ala Val Tyr Gly Phe Met Pro Ala Lys Ala Thr Ile Phe Asn Leu
    290                 295                 300                 
Lys Cys Asp Pro Val Phe Asp Phe Gly Thr Gly Pro Arg Asn Ala Ala
305                 310                 315                 320 
Tyr Tyr Ser Pro His Gly His Ile Leu Val Leu Ala Gly Phe Gly Asn
                325                 330                 335     
Leu Arg Gly Gln Met Glu Val Trp Asp Val Lys Asn Tyr Lys Leu Ile
            340                 345                 350         
Ser Lys Pro Val Ala Ser Asp Ser Thr Tyr Phe Ala Trp Cys Pro Asp
        355                 360                 365             
Gly Glu His Ile Leu Thr Ala Thr Cys Ala Pro Arg Leu Arg Val Asn
    370                 375                 380                 
Asn Gly Tyr Lys Ile Trp His Tyr Thr Gly Ser Ile Leu His Lys Tyr
385                 390                 395                 400 
Asp Val Pro Ser Asn Ala Glu Leu Trp Gln Val Ser Trp Gln Pro Phe
                405                 410                 415     
Leu Asp Gly Ile Phe Pro Ala Lys Thr Ile Thr Tyr Gln Ala Val Pro
            420                 425                 430         
Ser Glu Val Pro Asn Glu Glu Pro Lys Val Ala Thr Ala Tyr Arg Pro
        435                 440                 445             
Pro Ala Leu Arg Asn Lys Pro Ile Thr Asn Ser Lys Leu His Glu Glu
    450                 455                 460                 
Glu Pro Pro Gln Asn Met Lys Pro Gln Ser Gly Asn Asp Lys Pro Leu
465                 470                 475                 480 
Ser Lys Thr Ala Leu Lys Asn Gln Arg Lys His Glu Ala Lys Lys Ala
                485                 490                 495     
Ala Lys Gln Glu Ala Arg Ser Asp Lys Ser Pro Asp Leu Ala Pro Thr
            500                 505                 510         
Pro Ala Pro Gln Ser Thr Pro Arg Asn Thr Val Ser Gln Ser Ile Ser
        515                 520                 525             
Gly Asp Pro Glu Ile Asp Lys Lys Ile Lys Asn Leu Lys Lys Lys Leu
    530                 535                 540                 
Lys Ala Ile Glu Gln Leu Lys Glu Gln Ala Ala Thr Gly Lys Gln Leu
545                 550                 555                 560 
Glu Lys Asn Gln Leu Glu Lys Ile Gln Lys Glu Thr Ala Leu Leu Gln
                565                 570                 575     
Glu Leu Glu Asp Leu Glu Leu Gly Ile
            580                 585 


<210> 1788
<211> 1287
<212> PRT
<213> Homo sapiens

<400> 1788
Met Val Pro Gly Glu Glu Asn Gln Leu Val Pro Lys Glu Ala Pro Leu
 1               5                  10                  15      
Asp His Thr Ser Asp Lys Ser Leu Leu Asp Ala Asn Phe Glu Pro Gly
            20                  25                  30          
Lys Lys Asn Phe Leu His Leu Thr Asp Lys Asp Gly Glu Gln Pro Gln
        35                  40                  45              
Ile Leu Leu Glu Asp Ser Ser Ala Gly Glu Asp Ser Val His Asp Arg
    50                  55                  60                  
Phe Ile Gly Pro Leu Pro Arg Glu Gly Ser Val Gly Ser Thr Ser Asp
65                  70                  75                  80  
Tyr Val Ser Gln Ser Tyr Ser Tyr Ser Ser Ile Leu Asn Lys Ser Glu
                85                  90                  95      
Thr Gly Tyr Val Gly Leu Val Asn Gln Ala Met Thr Cys Tyr Leu Asn
            100                 105                 110         
Ser Leu Leu Gln Thr Leu Phe Met Thr Pro Glu Phe Arg Asn Ala Leu
        115                 120                 125             
Tyr Lys Trp Glu Phe Glu Glu Ser Glu Glu Asp Pro Val Thr Ser Ile
    130                 135                 140                 
Pro Tyr Gln Leu Gln Arg Leu Phe Val Leu Leu Gln Thr Ser Lys Lys
145                 150                 155                 160 
Arg Ala Ile Glu Thr Thr Asp Val Thr Arg Ser Phe Gly Trp Asp Ser
                165                 170                 175     
Ser Glu Ala Trp Gln Gln His Asp Val Gln Glu Leu Cys Arg Val Met
            180                 185                 190         
Phe Asp Ala Leu Glu Gln Lys Trp Lys Gln Thr Glu Gln Ala Asp Leu
        195                 200                 205             
Ile Asn Glu Leu Tyr Gln Gly Lys Leu Lys Asp Tyr Val Arg Cys Leu
    210                 215                 220                 
Glu Cys Gly Tyr Glu Gly Trp Arg Ile Asp Thr Tyr Leu Asp Ile Pro
225                 230                 235                 240 
Leu Val Ile Arg Pro Tyr Gly Ser Ser Gln Ala Phe Ala Ser Val Glu
                245                 250                 255     
Glu Ala Leu His Ala Phe Ile Gln Pro Glu Ile Leu Asp Gly Pro Asn
            260                 265                 270         
Gln Tyr Phe Cys Glu Arg Cys Lys Lys Lys Cys Asp Ala Arg Lys Gly
        275                 280                 285             
Leu Arg Phe Leu His Phe Pro Tyr Leu Leu Thr Leu Gln Leu Lys Arg
    290                 295                 300                 
Phe Asp Phe Asp Tyr Thr Thr Met His Arg Ile Lys Leu Asn Asp Arg
305                 310                 315                 320 
Met Thr Phe Pro Glu Glu Leu Asp Met Ser Thr Phe Ile Asp Val Glu
                325                 330                 335     
Asp Glu Lys Ser Pro Gln Thr Glu Ser Cys Thr Asp Ser Gly Ala Glu
            340                 345                 350         
Asn Glu Gly Ser Cys His Ser Asp Gln Met Ser Asn Asp Phe Ser Asn
        355                 360                 365             
Asp Asp Gly Val Asp Glu Gly Ile Cys Leu Glu Thr Asn Ser Gly Thr
    370                 375                 380                 
Glu Lys Ile Ser Lys Ser Gly Leu Glu Lys Asn Ser Leu Ile Tyr Glu
385                 390                 395                 400 
Leu Phe Ser Val Met Ala His Ser Gly Ser Ala Ala Gly Gly His Tyr
                405                 410                 415     
Tyr Ala Cys Ile Lys Ser Phe Ser Asp Glu Gln Trp Tyr Ser Phe Asp
            420                 425                 430         
Asp Gln His Val Ser Arg Ile Thr Gln Glu Asp Ile Lys Lys Thr His
        435                 440                 445             
Gly Gly Ser Ser Gly Ser Arg Gly Tyr Tyr Ser Ser Ala Phe Ala Ser
    450                 455                 460                 
Ser Thr Asn Ala Tyr Met Leu Ile Tyr Arg Leu Lys Asp Pro Ala Arg
465                 470                 475                 480 
Asn Ala Lys Phe Leu Glu Val Gly Glu Tyr Pro Glu His Ile Lys Asn
                485                 490                 495     
Leu Val Gln Lys Glu Arg Glu Leu Glu Glu Gln Glu Lys Arg Gln Arg
            500                 505                 510         
Glu Ile Glu Arg Asn Thr Cys Lys Ile Lys Leu Phe Cys Leu His Pro
        515                 520                 525             
Thr Lys Gln Val Met Met Glu Asn Lys Leu Glu Val His Lys Asp Lys
    530                 535                 540                 
Thr Leu Lys Glu Ala Val Glu Met Ala Tyr Lys Met Met Asp Leu Glu
545                 550                 555                 560 
Glu Val Ile Pro Leu Asp Cys Cys Arg Leu Val Lys Tyr Asp Glu Phe
                565                 570                 575     
His Asp Tyr Leu Glu Arg Ser Tyr Glu Gly Glu Glu Asp Thr Pro Met
            580                 585                 590         
Gly Leu Leu Leu Gly Gly Val Lys Ser Thr Tyr Met Phe Asp Leu Leu
        595                 600                 605             
Leu Glu Thr Arg Lys Pro Asp Gln Val Phe Gln Ser Tyr Lys Pro Gly
    610                 615                 620                 
Glu Val Met Val Lys Val His Val Val Asp Leu Lys Ala Glu Ser Val
625                 630                 635                 640 
Ala Ala Pro Ile Thr Val Arg Ala Tyr Leu Asn Gln Thr Val Thr Glu
                645                 650                 655     
Phe Lys Gln Leu Ile Ser Lys Ala Ile His Leu Pro Ala Glu Thr Met
            660                 665                 670         
Arg Ile Val Leu Glu Arg Cys Tyr Asn Asp Leu Arg Leu Leu Ser Val
        675                 680                 685             
Ser Ser Lys Thr Leu Lys Ala Glu Gly Phe Phe Arg Ser Asn Lys Val
    690                 695                 700                 
Phe Val Glu Ser Ser Glu Thr Leu Asp Tyr Gln Met Ala Phe Ala Asp
705                 710                 715                 720 
Ser His Leu Trp Lys Leu Leu Asp Arg His Ala Asn Thr Ile Arg Leu
                725                 730                 735     
Phe Val Leu Leu Pro Glu Gln Ser Pro Val Ser Tyr Ser Lys Arg Thr
            740                 745                 750         
Ala Tyr Gln Lys Ala Gly Gly Asp Ser Gly Asn Val Asp Asp Asp Cys
        755                 760                 765             
Glu Arg Val Lys Gly Pro Val Gly Ser Leu Lys Ser Val Glu Ala Ile
    770                 775                 780                 
Leu Glu Glu Ser Thr Glu Lys Leu Lys Ser Leu Ser Leu Gln Gln Gln
785                 790                 795                 800 
Gln Asp Gly Asp Asn Gly Asp Ser Ser Lys Ser Thr Glu Thr Ser Asp
                805                 810                 815     
Phe Glu Asn Ile Glu Ser Pro Leu Asn Glu Arg Asp Ser Ser Ala Ser
            820                 825                 830         
Val Asp Asn Arg Glu Leu Glu Gln His Ile Gln Thr Ser Asp Pro Glu
        835                 840                 845             
Asn Phe Gln Ser Glu Glu Arg Ser Asp Ser Asp Val Asn Asn Asp Arg
    850                 855                 860                 
Ser Thr Ser Ser Val Asp Ser Asp Ile Leu Ser Ser Ser His Ser Ser
865                 870                 875                 880 
Asp Thr Leu Cys Asn Ala Asp Asn Ala Gln Ile Pro Leu Ala Asn Gly
                885                 890                 895     
Leu Asp Ser His Ser Ile Thr Ser Ser Arg Arg Thr Lys Ala Asn Glu
            900                 905                 910         
Gly Lys Lys Glu Thr Trp Asp Thr Ala Glu Glu Asp Ser Gly Thr Asp
        915                 920                 925             
Ser Glu Tyr Asp Glu Ser Gly Lys Ser Arg Gly Glu Met Gln Tyr Met
    930                 935                 940                 
Tyr Phe Lys Ala Glu Pro Tyr Ala Ala Asp Glu Gly Ser Gly Glu Gly
945                 950                 955                 960 
His Lys Trp Leu Met Val His Val Asp Lys Arg Ile Thr Leu Ala Ala
                965                 970                 975     
Phe Lys Gln His Leu Glu Pro Phe Val Gly Val Leu Ser Ser His Phe
            980                 985                 990         
Lys Val Phe Arg Val Tyr Ala Ser Asn Gln Glu Phe Glu Ser Val Arg
        995                 1000                1005            
Leu Asn Glu Thr Leu Ser Ser Phe Ser Asp Asp Asn Lys Ile Thr Ile
    1010                1015                1020                
Arg Leu Gly Arg Ala Leu Lys Lys Gly Glu Tyr Arg Val Lys Val Tyr
1025                1030                1035                1040
Gln Leu Leu Val Asn Glu Gln Glu Pro Cys Lys Phe Leu Leu Asp Ala
                1045                1050                1055    
Val Phe Ala Lys Gly Met Thr Val Arg Gln Ser Lys Glu Glu Leu Ile
            1060                1065                1070        
Pro Gln Leu Arg Glu Gln Cys Gly Leu Glu Leu Ser Ile Asp Arg Phe
        1075                1080                1085            
Arg Leu Arg Lys Lys Thr Trp Lys Asn Pro Gly Thr Val Phe Leu Asp
    1090                1095                1100                
Tyr His Ile Tyr Glu Glu Asp Ile Asn Ile Ser Ser Asn Trp Glu Val
1105                1110                1115                1120
Phe Leu Glu Val Leu Asp Gly Val Glu Lys Met Lys Ser Met Ser Gln
                1125                1130                1135    
Leu Ala Val Leu Ser Arg Arg Trp Lys Pro Ser Glu Met Lys Leu Asp
            1140                1145                1150        
Pro Phe Gln Glu Val Val Leu Glu Ser Ser Ser Val Asp Glu Leu Arg
        1155                1160                1165            
Glu Lys Leu Ser Glu Ile Ser Gly Ile Pro Leu Asp Asp Ile Glu Phe
    1170                1175                1180                
Ala Lys Gly Arg Gly Thr Phe Pro Cys Asp Ile Ser Val Leu Asp Ile
1185                1190                1195                1200
His Gln Asp Leu Asp Trp Asn Pro Lys Val Ser Thr Leu Asn Val Trp
                1205                1210                1215    
Pro Leu Tyr Ile Cys Asp Asp Gly Ala Val Ile Phe Tyr Arg Asp Lys
            1220                1225                1230        
Thr Glu Glu Leu Met Glu Leu Thr Asp Glu Gln Arg Asn Glu Leu Met
        1235                1240                1245            
Lys Lys Glu Ser Ser Arg Leu Gln Lys Thr Gly His Arg Val Thr Tyr
    1250                1255                1260                
Ser Pro Arg Lys Glu Lys Ala Leu Lys Ile Tyr Leu Asp Gly Ala Pro
1265                1270                1275                1280
Asn Lys Asp Leu Thr Gln Asp
                1285        


<210> 1789
<211> 455
<212> PRT
<213> Homo sapiens

<400> 1789
Met Val Glu Gln Ser Glu Lys Leu Asn Gly Val Leu Glu Ala Ser Arg
 1               5                  10                  15      
Leu Trp Asp Asn Met Arg Lys Leu Gly Glu Cys Thr Glu Glu Ala His
            20                  25                  30          
Gln Met Thr His Asp Gly Tyr Leu Lys Leu Trp Gln Leu Ser Lys Pro
        35                  40                  45              
Ser Leu Ala Ser Phe Asp Ala Ile Phe Val Asp Glu Ala Gln Asp Cys
    50                  55                  60                  
Thr Pro Ala Ile Met Asn Ile Val Leu Ser Gln Pro Cys Gly Lys Ile
65                  70                  75                  80  
Phe Val Gly Asp Pro His Gln Gln Ile Tyr Thr Phe Arg Gly Ala Val
                85                  90                  95      
Asn Ala Leu Phe Thr Val Pro His Thr His Val Phe Tyr Leu Thr Gln
            100                 105                 110         
Ser Phe Arg Phe Gly Val Glu Ile Ala Tyr Val Gly Ala Thr Ile Leu
        115                 120                 125             
Asp Val Cys Lys Arg Val Arg Lys Lys Thr Leu Val Gly Gly Asn His
    130                 135                 140                 
Gln Ser Gly Ile Arg Gly Asp Ala Lys Gly Gln Val Ala Leu Leu Ser
145                 150                 155                 160 
Arg Thr Asn Ala Asn Val Phe Asp Glu Ala Val Arg Val Thr Glu Gly
                165                 170                 175     
Glu Phe Pro Ser Arg Ile His Leu Ile Gly Gly Ile Lys Ser Phe Gly
            180                 185                 190         
Leu Asp Arg Ile Ile Asp Ile Trp Ile Leu Leu Gln Pro Glu Glu Glu
        195                 200                 205             
Arg Arg Lys Gln Asn Leu Val Ile Lys Asp Lys Phe Ile Arg Arg Trp
    210                 215                 220                 
Val His Lys Glu Gly Phe Ser Gly Phe Lys Arg Tyr Val Thr Ala Ala
225                 230                 235                 240 
Glu Asp Lys Glu Leu Glu Ala Lys Ile Ala Val Val Glu Lys Tyr Asn
                245                 250                 255     
Ile Arg Ile Pro Glu Leu Val Gln Arg Ile Glu Lys Cys His Ile Glu
            260                 265                 270         
Asp Leu Asp Phe Ala Glu Tyr Ile Leu Gly Thr Val His Lys Ala Lys
        275                 280                 285             
Gly Leu Glu Phe Asp Thr Val His Val Leu Asp Asp Phe Val Lys Val
    290                 295                 300                 
Pro Cys Ala Arg His Asn Leu Pro Gln Leu Pro His Phe Arg Val Glu
305                 310                 315                 320 
Ser Phe Ser Glu Asp Glu Trp Asn Leu Leu Tyr Val Ala Val Thr Arg
                325                 330                 335     
Ala Lys Lys Arg Leu Ile Met Thr Lys Ser Leu Glu Asn Ile Leu Thr
            340                 345                 350         
Leu Ala Gly Glu Tyr Phe Leu Gln Ala Glu Leu Thr Ser Asn Val Leu
        355                 360                 365             
Lys Thr Gly Val Val Arg Cys Cys Val Gly Gln Cys Asn Asn Ala Ile
    370                 375                 380                 
Pro Val Asp Thr Val Leu Thr Met Lys Lys Leu Pro Ile Thr Tyr Ser
385                 390                 395                 400 
Asn Arg Lys Glu Asn Lys Gly Gly Tyr Leu Cys His Ser Cys Ala Glu
                405                 410                 415     
Gln Arg Ile Gly Pro Leu Ala Phe Leu Thr Ala Ser Pro Glu Gln Val
            420                 425                 430         
Arg Ala Met Glu Arg Thr Val Glu Asn Ile Val Leu Pro Arg His Glu
        435                 440                 445             
Ala Leu Leu Phe Leu Val Phe
    450                 455 


<210> 1790
<211> 732
<212> PRT
<213> Homo sapiens

<400> 1790
Met Glu Arg Gly Gly Gly Gly Ser Gly Thr Gly Ser Arg Pro Glu Gly
 1               5                  10                  15      
Thr Ala Arg Gly Thr Ser Leu Pro Gly Lys Ile Ala Glu Pro Gly Ala
            20                  25                  30          
Val Arg Thr Ser Gln Pro Asn Tyr Arg Pro Gln Gly Met Glu Gly Phe
        35                  40                  45              
Leu Lys Ser Asp Glu Arg Gln Arg Leu Ala Lys Glu Arg Arg Glu Glu
    50                  55                  60                  
Arg Glu Lys Cys Leu Ala Ala Arg Glu Gln Gln Ile Leu Glu Lys Gln
65                  70                  75                  80  
Lys Arg Ala Arg Leu Gln Tyr Glu Lys Gln Met Glu Glu Arg Trp Arg
                85                  90                  95      
Lys Leu Glu Glu Gln Arg Gln Arg Glu Asp Gln Lys Arg Ala Ala Val
            100                 105                 110         
Glu Glu Lys Arg Lys Gln Lys Leu Arg Glu Glu Glu Glu Arg Leu Glu
        115                 120                 125             
Ala Met Met Arg Arg Ser Leu Glu Arg Thr Gln Gln Leu Glu Leu Lys
    130                 135                 140                 
Lys Lys Tyr Ser Trp Gly Ala Pro Leu Ala Ile Gly Pro Gly Gly His
145                 150                 155                 160 
Asp Ala Cys Asp Lys Leu Ser Thr Ser Thr Met Ser Leu Pro Lys Pro
                165                 170                 175     
Thr Glu Pro Pro Met Asn Lys Arg Leu Ser Ser Ser Thr Val Ala Ile
            180                 185                 190         
Ser Tyr Ser Pro Asp Arg Val Phe His Val Cys Pro Arg Leu Ala Pro
        195                 200                 205             
Leu Gly Pro Leu Asn Pro Ser Tyr Lys Ser Ser Pro Thr Arg Asn Ile
    210                 215                 220                 
Glu Lys Lys Lys Ala Thr Ser Thr Ser Thr Ser Gly Ala Gly Asp Val
225                 230                 235                 240 
Gly Lys Glu Ala Leu Ser Gly Gly Glu Ala Ser Leu Val Glu Lys Val
                245                 250                 255     
Lys Arg Gly Gln Arg Thr Ala Thr Ser Leu Pro Val Val Asn Phe Gly
            260                 265                 270         
Ser Pro Leu Arg Arg Cys Glu Phe Ser Gly Gly Ile Pro Lys Arg Pro
        275                 280                 285             
Ser Ser Pro Val Ile Ser Lys Thr Ala Thr Lys Ala Tyr Pro Gln Ser
    290                 295                 300                 
Pro Lys Thr Thr Lys Pro Pro Tyr Pro Gly Ser Pro Val Lys Tyr Arg
305                 310                 315                 320 
Leu Pro Ala Leu Ser Gly Gln Asp Met Pro Lys Arg Lys Ala Glu Lys
                325                 330                 335     
Glu Lys Ser Asn Lys Glu Arg Glu Gly Thr Leu Ala Gln Gln Ala Ala
            340                 345                 350         
Gly Pro Gln Gly Glu Glu Ala Leu Glu Lys His Val Val Asp Lys His
        355                 360                 365             
Ala Ser Glu Lys His Ala Ala Ala Ala Gly Gly Lys Ala Glu Asn Ser
    370                 375                 380                 
Ala Ala Leu Gly Lys Pro Thr Ala Gly Thr Thr Asp Ala Gly Glu Ala
385                 390                 395                 400 
Ala Lys Ile Leu Ala Glu Lys Arg Arg Gln Ala Arg Leu Gln Lys Glu
                405                 410                 415     
Gln Glu Glu Gln Glu Arg Val Glu Lys Glu Glu Gln Asp Arg Leu Glu
            420                 425                 430         
Arg Glu Glu Leu Lys Arg Lys Ala Glu Glu Glu Arg Leu Arg Leu Glu
        435                 440                 445             
Glu Glu Ala Arg Lys Gln Glu Glu Glu Arg Lys Arg Gln Glu Glu Glu
    450                 455                 460                 
Lys Lys Lys Gln Glu Gly Glu Glu Lys Arg Lys Ala Gly Glu Glu Ala
465                 470                 475                 480 
Lys Arg Lys Ala Glu Glu Glu Leu Leu Leu Lys Glu Lys Gln Glu Gln
                485                 490                 495     
Glu Lys Gln Glu Lys Ala Met Ile Glu Lys Gln Lys Glu Ala Ala Glu
            500                 505                 510         
Thr Lys Ala Arg Glu Val Ala Glu Gln Met Arg Leu Glu Arg Glu Gln
        515                 520                 525             
Ile Met Leu Gln Ile Glu Gln Glu Arg Leu Glu Arg Lys Lys Arg Ile
    530                 535                 540                 
Asp Glu Ile Met Lys Arg Thr Arg Lys Ser Asp Val Pro Pro Gln Val
545                 550                 555                 560 
Lys Lys Glu Asp Pro Lys Val Gly Val Gln Pro Ala Val Cys Val Glu
                565                 570                 575     
Lys Lys Thr Lys Leu Val Val Pro Asn Lys Met Glu Ile Asn Gly Leu
            580                 585                 590         
Asn Thr Cys Gln Glu Val Asn Gly Val Asp His Ala Ala Pro Glu Thr
        595                 600                 605             
Tyr Pro Gln Asp Ile Phe Ser Asn Gly Leu Lys Pro Ala Gly Gly Leu
    610                 615                 620                 
Ile His Leu Asp Ala Leu Asp Gly Lys Ser Asn Ser Leu Asp Asp Ser
625                 630                 635                 640 
Thr Glu Glu Val Gln Ser Met Asp Val Ser Pro Val Ser Lys Glu Glu
                645                 650                 655     
Leu Ile Ser Ile Pro Glu Phe Ser Pro Val Ser Glu Met Ile Pro Gly
            660                 665                 670         
Val Ser Leu Asp Gln Asn Gly Thr Gly Asn Ala Arg Ala Leu Gln Asp
        675                 680                 685             
Leu Leu Asp Phe Thr Gly Pro Pro Thr Phe Pro Lys Arg Ser Ser Glu
    690                 695                 700                 
Asn Leu Ser Leu Asp Asp Cys Asn Lys Asn Leu Ile Glu Gly Phe Asn
705                 710                 715                 720 
Ser Pro Gly Gln Glu Thr Pro Leu Asn Thr Phe Cys
                725                 730         


<210> 1791
<211> 504
<212> PRT
<213> Homo sapiens

<400> 1791
Met Ala Ala Cys Arg Tyr Cys Cys Ser Cys Leu Arg Leu Arg Pro Leu
 1               5                  10                  15      
Ser Asp Gly Pro Phe Leu Leu Pro Arg Arg Asp Arg Ala Leu Thr Gln
            20                  25                  30          
Leu Gln Val Arg Ala Leu Trp Ser Ser Ala Gly Ser Arg Ala Val Ala
        35                  40                  45              
Val Asp Leu Gly Asn Arg Lys Leu Glu Ile Ser Ser Gly Lys Leu Ala
    50                  55                  60                  
Arg Phe Ala Asp Gly Ser Ala Val Val Gln Ser Gly Asp Thr Ala Val
65                  70                  75                  80  
Met Val Thr Ala Val Ser Lys Thr Lys Pro Ser Pro Ser Gln Phe Met
                85                  90                  95      
Pro Leu Val Val Asp Tyr Arg Gln Lys Ala Ala Ala Ala Gly Arg Ile
            100                 105                 110         
Pro Thr Asn Tyr Leu Arg Arg Glu Val Gly Thr Ser Asp Lys Glu Ile
        115                 120                 125             
Leu Thr Ser Arg Ile Ile Asp Arg Ser Ile Arg Pro Leu Phe Pro Ala
    130                 135                 140                 
Gly Tyr Phe Tyr Asp Thr Gln Val Leu Cys Asn Leu Leu Ala Val Asp
145                 150                 155                 160 
Gly Val Asn Glu Pro Asp Val Leu Ala Ile Asn Gly Ala Ser Val Ala
                165                 170                 175     
Leu Ser Leu Ser Asp Ile Pro Trp Asn Gly Pro Val Gly Ala Val Arg
            180                 185                 190         
Ile Gly Ile Ile Asp Gly Glu Tyr Val Val Asn Pro Thr Arg Lys Glu
        195                 200                 205             
Met Ser Ser Ser Thr Leu Asn Leu Val Val Ala Gly Ala Pro Lys Ser
    210                 215                 220                 
Gln Ile Val Met Leu Glu Ala Ser Ala Glu Asn Ile Leu Gln Gln Asp
225                 230                 235                 240 
Phe Cys His Ala Ile Lys Val Gly Val Lys Tyr Thr Gln Gln Ile Ile
                245                 250                 255     
Gln Gly Ile Gln Gln Leu Val Lys Glu Thr Gly Val Thr Lys Arg Thr
            260                 265                 270         
Pro Gln Lys Leu Phe Thr Pro Ser Pro Glu Ile Val Lys Tyr Thr His
        275                 280                 285             
Lys Leu Ala Met Glu Arg Leu Tyr Ala Val Phe Thr Asp Tyr Glu His
    290                 295                 300                 
Asp Lys Val Ser Arg Asp Glu Ala Val Asn Lys Ile Arg Leu Asp Thr
305                 310                 315                 320 
Glu Glu Gln Leu Lys Glu Lys Phe Pro Glu Ala Asp Pro Tyr Glu Ile
                325                 330                 335     
Ile Glu Ser Phe Asn Val Val Ala Lys Glu Val Phe Arg Ser Ile Val
            340                 345                 350         
Leu Asn Glu Tyr Lys Arg Cys Asp Gly Arg Asp Leu Thr Ser Leu Arg
        355                 360                 365             
Asn Val Ser Cys Glu Val Asp Met Phe Lys Thr Leu His Gly Ser Ala
    370                 375                 380                 
Leu Phe Gln Arg Gly Gln Thr Gln Val Leu Cys Thr Val Thr Phe Asp
385                 390                 395                 400 
Ser Leu Glu Ser Gly Ile Lys Ser Asp Gln Val Ile Thr Ala Ile Asn
                405                 410                 415     
Gly Ile Lys Asp Lys Asn Phe Met Leu His Tyr Glu Phe Pro Pro Tyr
            420                 425                 430         
Ala Thr Asn Glu Ile Gly Lys Val Thr Gly Leu Asn Arg Arg Glu Leu
        435                 440                 445             
Gly His Gly Ala Leu Ala Glu Lys Ala Leu Tyr Pro Val Ile Pro Arg
    450                 455                 460                 
Asp Phe Pro Ser Leu Ser Ala Ile Phe Pro Arg Arg His Asn Gly Ala
465                 470                 475                 480 
His Glu Cys Pro Gly Arg Cys Ser Gln Glu Tyr Gln Gln Cys Arg Lys
                485                 490                 495     
Glu Arg Gln Thr Pro Gly Ala Tyr
            500                 


<210> 1792
<211> 530
<212> PRT
<213> Homo sapiens

<400> 1792
Met Ser Asp Gly Lys Glu Ile Thr Phe Leu Glu Tyr Tyr Ser Lys Asn
 1               5                  10                  15      
Tyr Gly Ile Thr Val Lys Glu Glu Asp Gln Pro Leu Leu Ile His Arg
            20                  25                  30          
Pro Ser Glu Arg Gln Asp Asn His Gly Met Leu Leu Lys Gly Glu Ile
        35                  40                  45              
Leu Leu Leu Pro Glu Leu Ser Phe Met Thr Gly Ile Pro Glu Lys Met
    50                  55                  60                  
Lys Lys Asp Phe Arg Ala Met Lys Asp Leu Ala Gln Gln Ile Asn Leu
65                  70                  75                  80  
Ser Pro Lys Gln His His Ser Ala Leu Glu Cys Leu Leu Gln Arg Ile
                85                  90                  95      
Ala Lys Asn Glu Ala Ala Thr Asn Glu Leu Met Arg Trp Gly Leu Arg
            100                 105                 110         
Leu Gln Lys Asp Val His Lys Ile Glu Gly Arg Val Leu Pro Met Glu
        115                 120                 125             
Arg Ile Asn Leu Lys Asn Thr Ser Phe Ile Thr Ser Gln Glu Leu Asn
    130                 135                 140                 
Trp Val Lys Glu Val Thr Arg Asp Pro Ser Ile Leu Thr Ile Pro Met
145                 150                 155                 160 
His Phe Trp Ala Leu Phe Tyr Pro Lys Arg Ala Met Asp Gln Ala Arg
                165                 170                 175     
Glu Leu Val Asn Met Leu Glu Lys Ile Ala Gly Pro Ile Gly Met Arg
            180                 185                 190         
Met Ser Pro Pro Ala Trp Val Glu Leu Lys Asp Asp Arg Ile Glu Thr
        195                 200                 205             
Tyr Val Arg Thr Ile Gln Ser Thr Leu Gly Ala Glu Gly Lys Ile Gln
    210                 215                 220                 
Met Val Val Cys Ile Ile Met Gly Pro Arg Asp Asp Leu Tyr Gly Ala
225                 230                 235                 240 
Ile Lys Lys Leu Cys Cys Val Gln Ser Pro Val Pro Ser Gln Val Val
                245                 250                 255     
Asn Val Arg Thr Ile Gly Gln Pro Thr Arg Leu Arg Ser Val Ala Gln
            260                 265                 270         
Lys Ile Leu Leu Gln Ile Asn Cys Lys Leu Gly Gly Glu Leu Trp Gly
        275                 280                 285             
Val Asp Ile Pro Leu Lys Gln Leu Met Val Ile Gly Met Asp Val Tyr
    290                 295                 300                 
His Asp Pro Ser Arg Gly Met Arg Ser Val Val Gly Phe Val Ala Ser
305                 310                 315                 320 
Ile Asn Leu Thr Leu Thr Lys Trp Tyr Ser Arg Val Val Phe Gln Met
                325                 330                 335     
Pro His Gln Glu Ile Val Asp Ser Leu Lys Leu Cys Leu Val Gly Ser
            340                 345                 350         
Leu Lys Lys Phe Tyr Glu Val Asn His Cys Leu Pro Glu Lys Ile Val
        355                 360                 365             
Val Tyr Arg Asp Gly Val Ser Asp Gly Gln Leu Lys Thr Val Ala Asn
    370                 375                 380                 
Tyr Glu Ile Pro Gln Leu Gln Lys Cys Phe Glu Ala Phe Glu Asn Tyr
385                 390                 395                 400 
Gln Pro Lys Met Val Val Phe Val Val Gln Lys Lys Ile Ser Thr Asn
                405                 410                 415     
Leu Tyr Leu Ala Ala Pro Gln Asn Phe Val Thr Pro Thr Pro Gly Thr
            420                 425                 430         
Val Val Asp His Thr Ile Thr Ser Cys Glu Trp Val Asp Phe Tyr Leu
        435                 440                 445             
Leu Ala His His Val Arg Gln Gly Cys Gly Ile Pro Thr His Tyr Val
    450                 455                 460                 
Cys Val Leu Asn Thr Ala Asn Leu Ser Pro Asp His Met Gln Arg Leu
465                 470                 475                 480 
Thr Phe Lys Leu Cys His Met Tyr Trp Asn Trp Pro Gly Thr Ile Arg
                485                 490                 495     
Val Pro Ala Pro Cys Lys Tyr Ala His Lys Leu Ala Phe Leu Ser Gly
            500                 505                 510         
His Ile Leu His His Gly Pro Ala Ile Gln Leu Cys Glu Asn Leu Phe
        515                 520                 525             
Phe Leu
    530 


<210> 1793
<211> 819
<212> PRT
<213> Homo sapiens

<400> 1793
Met Asp Ser Glu Tyr Tyr Ser Gly Asp Gln Ser Asp Asp Gly Gly Ala
 1               5                  10                  15      
Thr Pro Val Gln Asp Glu Arg Asp Ser Gly Ser Asp Gly Glu Asp Asp
            20                  25                  30          
Val Asn Glu Gln His Ser Gly Ser Asp Thr Gly Ser Val Glu Arg His
        35                  40                  45              
Ser Glu Asn Glu Thr Ser Asp Arg Glu Asp Gly Leu Pro Lys Gly His
    50                  55                  60                  
His Val Thr Asp Ser Glu Asn Asp Glu Pro Leu Asn Leu Asn Ala Ser
65                  70                  75                  80  
Asp Ser Glu Ser Glu Glu Leu His Arg Gln Lys Asp Ser Asp Ser Glu
                85                  90                  95      
Ser Glu Glu Arg Ala Glu Pro Pro Ala Ser Asp Ser Glu Asn Glu Asp
            100                 105                 110         
Val Asn Gln His Gly Ser Asp Ser Glu Ser Glu Glu Thr Arg Lys Leu
        115                 120                 125             
Pro Gly Ser Asp Ser Glu Asn Glu Glu Leu Leu Asn Gly His Ala Ser
    130                 135                 140                 
Asp Ser Glu Asn Glu Asp Val Gly Lys His Pro Ala Ser Asp Ser Glu
145                 150                 155                 160 
Ile Glu Glu Leu Gln Lys Ser Pro Ala Ser Asp Ser Glu Thr Glu Asp
                165                 170                 175     
Ala Leu Lys Pro Gln Ile Ser Asp Ser Glu Ser Glu Glu Pro Pro Arg
            180                 185                 190         
His Gln Ala Ser Asp Ser Glu Asn Glu Glu Pro Pro Lys Pro Arg Met
        195                 200                 205             
Ser Asp Ser Glu Ser Glu Glu Leu Pro Lys Pro Gln Val Ser Asp Ser
    210                 215                 220                 
Glu Ser Glu Glu Pro Pro Arg His Gln Ala Ser Asp Ser Glu Asn Glu
225                 230                 235                 240 
Glu Leu Pro Arg Pro Arg Ile Ser Asp Ser Glu Ser Glu Asp Pro Pro
                245                 250                 255     
Arg His Gln Ala Ser Asp Ser Glu Asn Glu Glu Leu Pro Lys Pro Arg
            260                 265                 270         
Ile Ser Asp Ser Glu Ser Glu Asp Pro Pro Arg Asn Gln Ala Ser Asp
        275                 280                 285             
Ser Glu Asn Glu Glu Leu Pro Lys Pro Arg Val Ser Asp Ser Glu Ser
    290                 295                 300                 
Glu Gly Pro Gln Lys Gly Pro Ala Ser Asp Ser Glu Thr Glu Asp Ala
305                 310                 315                 320 
Ser Arg His Lys Gln Lys Pro Glu Ser Asp Asp Asp Ser Asp Arg Glu
                325                 330                 335     
Asn Lys Gly Glu Asp Thr Glu Met Gln Asn Asp Ser Phe His Ser Asp
            340                 345                 350         
Ser His Met Asp Arg Lys Lys Phe His Ser Ser Asp Ser Glu Glu Glu
        355                 360                 365             
Glu His Lys Lys Gln Lys Met Asp Ser Asp Glu Asp Glu Lys Glu Gly
    370                 375                 380                 
Glu Glu Glu Lys Val Ala Lys Arg Lys Ala Ala Val Leu Ser Asp Ser
385                 390                 395                 400 
Glu Asp Glu Glu Lys Ala Ser Ala Lys Lys Ser Arg Val Val Ser Asp
                405                 410                 415     
Ala Asp Asp Ser Asp Ser Asp Ala Val Ser Asp Lys Ser Gly Lys Arg
            420                 425                 430         
Glu Lys Thr Ile Ala Ser Asp Ser Glu Glu Glu Ala Gly Lys Glu Leu
        435                 440                 445             
Ser Asp Lys Lys Asn Glu Glu Lys Asp Leu Phe Gly Ser Asp Ser Glu
    450                 455                 460                 
Ser Gly Asn Glu Glu Glu Asn Leu Ile Ala Asp Ile Phe Gly Glu Ser
465                 470                 475                 480 
Gly Asp Glu Glu Glu Glu Glu Phe Thr Gly Phe Asn Gln Glu Asp Leu
                485                 490                 495     
Glu Glu Glu Lys Gly Glu Thr Gln Val Lys Glu Ala Glu Asp Ser Asp
            500                 505                 510         
Ser Asp Asp Asn Ile Lys Arg Gly Lys His Met Asp Phe Leu Ser Asp
        515                 520                 525             
Phe Glu Met Met Leu Gln Arg Lys Lys Ser Met Ser Gly Lys Arg Arg
    530                 535                 540                 
Arg Asn Arg Asp Gly Gly Thr Phe Ile Ser Asp Ala Asp Asp Asp Val
545                 550                 555                 560 
Ser Ala Met Ile Val Lys Met Asn Glu Ala Ala Glu Glu Asp Arg Gln
                565                 570                 575     
Leu Asn Asn Gln Lys Lys Pro Ala Leu Lys Lys Leu Thr Leu Leu Pro
            580                 585                 590         
Ala Val Val Met His Leu Lys Lys Gln Asp Leu Lys Glu Thr Phe Ile
        595                 600                 605             
Asp Ser Gly Val Met Ser Ala Ile Lys Glu Trp Leu Ser Pro Leu Pro
    610                 615                 620                 
Asp Arg Ser Leu Pro Ala Leu Lys Ile Arg Glu Glu Leu Leu Lys Ile
625                 630                 635                 640 
Leu Gln Glu Leu Pro Ser Val Ser Gln Glu Thr Leu Lys His Ser Gly
                645                 650                 655     
Ile Gly Arg Ala Val Met Tyr Leu Tyr Lys His Pro Lys Glu Ser Arg
            660                 665                 670         
Ser Asn Lys Asp Met Ala Gly Lys Leu Ile Asn Glu Trp Ser Arg Pro
        675                 680                 685             
Ile Phe Gly Leu Thr Ser Asn Tyr Lys Gly Met Thr Arg Glu Glu Arg
    690                 695                 700                 
Glu Gln Arg Asp Leu Glu Gln Met Pro Gln Arg Arg Arg Met Asn Ser
705                 710                 715                 720 
Thr Gly Gly Gln Thr Pro Arg Arg Asp Leu Glu Lys Val Leu Thr Gly
                725                 730                 735     
Glu Glu Lys Ala Leu Arg Pro Gly Asp Pro Gly Phe Cys Ala Arg Ala
            740                 745                 750         
Arg Val Pro Met Pro Ser Asn Lys Asp Tyr Val Val Arg Pro Lys Trp
        755                 760                 765             
Asn Val Glu Met Glu Ser Ser Arg Phe Gln Ala Thr Ser Lys Lys Gly
    770                 775                 780                 
Ile Gly Arg Leu Asp Lys Gln Met Arg Lys Phe Thr Asp Ile Arg Lys
785                 790                 795                 800 
Lys Ser Arg Ser Ala His Ala Val Lys Ile Ser Ile Glu Gly Asn Lys
                805                 810                 815     
Met Pro Leu
            


<210> 1794
<211> 271
<212> PRT
<213> Homo sapiens

<400> 1794
Met Pro Ala Ser Gln Ser Arg Ala Arg Ala Arg Asp Arg Asn Asn Val
 1               5                  10                  15      
Leu Asn Arg Ala Glu Phe Leu Ser Leu Asn Gln Pro Pro Lys Gly Gly
            20                  25                  30          
Pro Glu Pro Arg Ser Ser Gly Arg Lys Ala Ser Gly Pro Ser Ala Gln
        35                  40                  45              
Pro Pro Pro Ala Gly Asp Gly Ala Arg Glu Arg Arg Gln Ser Gln Gln
    50                  55                  60                  
Leu Pro Glu Glu Asp Cys Met Gln Leu Asn Pro Ser Phe Lys Gly Ile
65                  70                  75                  80  
Ala Phe Asn Ser Leu Leu Ala Ile Asp Ile Cys Met Ser Lys Arg Leu
                85                  90                  95      
Gly Val Cys Ala Gly Arg Ala Ala Ser Trp Ala Ser Ala Arg Ser Met
            100                 105                 110         
Val Lys Leu Ile Gly Ile Thr Gly His Gly Ile Pro Trp Ile Gly Gly
        115                 120                 125             
Thr Ile Leu Cys Leu Val Lys Ser Ser Thr Leu Ala Gly Gln Glu Val
    130                 135                 140                 
Leu Met Asn Leu Leu Leu Ala Leu Leu Leu Asp Ile Met Thr Val Ala
145                 150                 155                 160 
Gly Val Gln Lys Leu Ile Lys Arg Arg Gly Pro Tyr Glu Thr Ser Pro
                165                 170                 175     
Ser Leu Leu Asp Tyr Leu Thr Met Asp Ile Tyr Ala Phe Pro Ala Gly
            180                 185                 190         
His Ala Ser Arg Ala Ala Met Val Ser Lys Tyr Phe Leu Ser His Leu
        195                 200                 205             
Val Leu Ala Val Pro Leu Arg Val Leu Leu Val Leu Trp Ala Leu Cys
    210                 215                 220                 
Val Gly Leu Ser Arg Val Met Ile Gly Arg His His Val Thr Asp Val
225                 230                 235                 240 
Leu Ser Gly Phe Val Ile Gly Tyr Leu Gln Phe Arg Leu Val Glu Leu
                245                 250                 255     
Val Trp Met Pro Ser Ser Thr Cys Gln Met Leu Ile Ser Ala Trp
            260                 265                 270     


<210> 1795
<211> 201
<212> PRT
<213> Homo sapiens

<400> 1795
Met Leu Phe Thr Ser Phe Val Glu Gln Lys Lys Lys Ala Gly Val Phe
 1               5                  10                  15      
Glu Gln Ile Thr Lys Thr His Gly Thr Ile Ile Gly Ile Thr Ser Gly
            20                  25                  30          
Ile Val Leu Val Leu Leu Ile Ile Ser Ile Leu Val Gln Val Lys Gln
        35                  40                  45              
Pro Arg Lys Lys Val Met Ala Cys Lys Thr Ala Phe Asn Lys Thr Gly
    50                  55                  60                  
Phe Gln Glu Val Phe Asp Pro Pro His Tyr Glu Leu Phe Ser Leu Arg
65                  70                  75                  80  
Asp Lys Glu Ile Ser Ala Asp Leu Ala Asp Leu Ser Glu Glu Leu Asp
                85                  90                  95      
Asn Tyr Gln Arg Met Arg Arg Ser Ser Thr Ala Ser Arg Cys Ile His
            100                 105                 110         
Asp His His Cys Gly Ser Gln Ala Ser Ser Val Lys Gln Ser Arg Thr
        115                 120                 125             
Asn Leu Ser Ser Met Glu Leu Pro Leu Arg Asn Asp Phe Ala Gln Pro
    130                 135                 140                 
Gln Pro Met Lys Thr Phe Asn Ser Thr Phe Lys Lys Ser Ser Tyr Thr
145                 150                 155                 160 
Phe Lys Gln Gly His Glu Cys Pro Glu Gln Ala Leu Glu Asp Arg Val
                165                 170                 175     
Met Glu Glu Ile Pro Cys Glu Ile Tyr Val Arg Gly Arg Glu Asp Ser
            180                 185                 190         
Ala Gln Ala Ser Ile Ser Ile Asp Phe
        195                 200     


<210> 1796
<211> 737
<212> PRT
<213> Homo sapiens

<400> 1796
Met Glu Leu Gly Cys Trp Thr Gln Leu Gly Leu Thr Phe Leu Gln Leu
 1               5                  10                  15      
Leu Leu Ile Ser Ser Leu Pro Arg Glu Tyr Thr Val Ile Asn Glu Ala
            20                  25                  30          
Cys Pro Gly Ala Glu Trp Asn Ile Met Cys Arg Glu Cys Cys Glu Tyr
        35                  40                  45              
Asp Gln Ile Glu Cys Val Cys Pro Gly Lys Arg Glu Val Val Gly Tyr
    50                  55                  60                  
Thr Ile Pro Cys Cys Arg Asn Glu Glu Asn Glu Cys Asp Ser Cys Leu
65                  70                  75                  80  
Ile His Pro Gly Cys Thr Ile Phe Glu Asn Cys Lys Ser Cys Arg Asn
                85                  90                  95      
Gly Ser Trp Gly Gly Thr Leu Asp Asp Phe Tyr Val Lys Gly Phe Tyr
            100                 105                 110         
Cys Ala Glu Cys Arg Ala Gly Trp Tyr Gly Gly Asp Cys Met Arg Cys
        115                 120                 125             
Gly Gln Val Leu Arg Ala Pro Lys Gly Gln Ile Leu Leu Glu Ser Tyr
    130                 135                 140                 
Pro Leu Asn Ala His Cys Glu Trp Thr Ile His Ala Lys Pro Gly Phe
145                 150                 155                 160 
Val Ile Gln Leu Arg Phe Val Met Leu Ser Leu Glu Phe Asp Tyr Met
                165                 170                 175     
Cys Gln Tyr Asp Tyr Val Glu Val Arg Asp Gly Asp Asn Arg Asp Gly
            180                 185                 190         
Gln Ile Ile Lys Arg Val Cys Gly Asn Glu Arg Pro Ala Pro Ile Gln
        195                 200                 205             
Ser Ile Gly Ser Ser Leu His Val Leu Phe His Ser Asp Gly Ser Lys
    210                 215                 220                 
Asn Phe Asp Gly Phe His Ala Ile Tyr Glu Glu Ile Thr Ala Cys Ser
225                 230                 235                 240 
Ser Ser Pro Cys Phe His Asp Gly Thr Cys Val Leu Asp Lys Ala Gly
                245                 250                 255     
Pro Tyr Lys Cys Ala Cys Leu Ala Gly Tyr Thr Gly Gln Arg Cys Glu
            260                 265                 270         
Asn Leu Leu Glu Ala Gly Lys Ser Lys Ile Lys Ala Ser Glu Asp Ser
        275                 280                 285             
Leu Ser Val Leu Glu Glu Arg Asn Cys Ser Asp Pro Gly Gly Pro Val
    290                 295                 300                 
Asn Gly Tyr Gln Lys Ile Thr Gly Gly Pro Gly Leu Ile Asn Gly Arg
305                 310                 315                 320 
His Ala Lys Ile Gly Thr Val Val Ser Phe Phe Cys Asn Asn Ser Tyr
                325                 330                 335     
Val Leu Ser Gly Asn Glu Lys Arg Thr Cys Gln Gln Asn Gly Glu Trp
            340                 345                 350         
Ser Gly Lys Gln Pro Ile Cys Ile Lys Ala Cys Arg Glu Pro Lys Ile
        355                 360                 365             
Ser Asp Leu Val Arg Arg Arg Val Leu Pro Met Gln Val Gln Ser Arg
    370                 375                 380                 
Glu Thr Pro Leu His Gln Leu Tyr Ser Ala Ala Phe Ser Lys Gln Lys
385                 390                 395                 400 
Leu Gln Ser Ala Pro Thr Lys Lys Pro Ala Leu Pro Phe Gly Asp Leu
                405                 410                 415     
Pro Met Gly Tyr Gln His Leu His Thr Gln Leu Gln Tyr Glu Cys Ile
            420                 425                 430         
Ser Pro Phe Tyr Arg Arg Leu Gly Ser Ser Arg Arg Thr Cys Leu Arg
        435                 440                 445             
Thr Gly Lys Trp Ser Gly Arg Ala Pro Ser Cys Ile Pro Ile Cys Gly
    450                 455                 460                 
Lys Ile Glu Asn Ile Thr Ala Pro Lys Thr Gln Gly Leu Arg Trp Pro
465                 470                 475                 480 
Trp Gln Ala Ala Ile Tyr Arg Arg Thr Ser Gly Val His Asp Gly Ser
                485                 490                 495     
Leu His Lys Gly Ala Trp Phe Leu Val Cys Ser Gly Ala Leu Val Asn
            500                 505                 510         
Glu Arg Thr Val Val Val Ala Ala His Cys Val Thr Asp Leu Gly Lys
        515                 520                 525             
Val Thr Met Ile Lys Thr Ala Asp Leu Lys Val Val Leu Gly Lys Phe
    530                 535                 540                 
Tyr Arg Asp Asp Asp Arg Asp Glu Lys Thr Ile Gln Ser Leu Gln Ile
545                 550                 555                 560 
Ser Ala Ile Ile Leu His Pro Asn Tyr Asp Pro Ile Leu Leu Asp Ala
                565                 570                 575     
Asp Ile Ala Ile Leu Lys Leu Leu Asp Lys Ala Arg Ile Ser Thr Arg
            580                 585                 590         
Val Gln Pro Ile Cys Leu Ala Ala Ser Arg Asp Leu Ser Thr Ser Phe
        595                 600                 605             
Gln Glu Ser His Ile Thr Val Ala Gly Trp Asn Val Leu Ala Asp Val
    610                 615                 620                 
Arg Ser Pro Gly Phe Lys Asn Asp Thr Leu Arg Ser Gly Val Val Ser
625                 630                 635                 640 
Val Val Asp Ser Leu Leu Cys Glu Glu Gln His Glu Asp His Gly Ile
                645                 650                 655     
Pro Val Ser Val Thr Asp Asn Met Phe Cys Ala Ser Trp Glu Pro Thr
            660                 665                 670         
Ala Pro Ser Asp Ile Cys Thr Ala Glu Thr Gly Gly Ile Ala Ala Val
        675                 680                 685             
Ser Phe Pro Gly Arg Ala Ser Pro Glu Pro Arg Trp His Leu Met Gly
    690                 695                 700                 
Leu Val Ser Trp Ser Tyr Asp Lys Thr Cys Ser His Arg Leu Ser Thr
705                 710                 715                 720 
Ala Phe Thr Lys Val Leu Pro Phe Lys Asp Trp Ile Glu Arg Asn Met
                725                 730                 735     
Lys
    


<210> 1797
<211> 426
<212> PRT
<213> Homo sapiens

<400> 1797
Met Ser Ser His Tyr Thr Glu Asp Leu Leu Pro Glu Gln Cys Met Gln
 1               5                  10                  15      
Asp Ser Phe Gln Lys Val Ile Leu Arg Arg Tyr Gly Ser Cys Gly Leu
            20                  25                  30          
Glu Asp Leu His Leu Arg Lys Asp Gly Glu Asn Val Gly Glu Cys Lys
        35                  40                  45              
Asp Gln Lys Glu Ile Tyr Asn Gly Leu Asn Gln Cys Leu Ser Thr Leu
    50                  55                  60                  
Pro Ser Lys Ile Phe Pro Tyr Asn Lys Cys Val Lys Val Phe Ser Lys
65                  70                  75                  80  
Ser Ser Asn Leu Asn Arg Glu Asn Ile Arg His Thr Thr Glu Lys Leu
                85                  90                  95      
Phe Lys Cys Met Gln Cys Gly Lys Val Phe Lys Ser His Ser Gly Leu
            100                 105                 110         
Ser Tyr His Lys Ile Ile His Thr Glu Glu Lys Leu Cys Ile Cys Glu
        115                 120                 125             
Glu Cys Gly Lys Thr Phe Lys Trp Phe Ser Tyr Leu Thr Lys His Lys
    130                 135                 140                 
Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys
145                 150                 155                 160 
Ala Phe Asn Trp Cys Ser Ser Leu Thr Lys His Lys Arg Ile His Thr
                165                 170                 175     
Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe His Trp
            180                 185                 190         
Cys Ser Pro Phe Val Arg His Lys Lys Ile His Thr Gly Glu Lys Pro
        195                 200                 205             
Tyr Thr Cys Glu Asp Cys Gly Arg Ala Phe Asn Arg His Ser His Leu
    210                 215                 220                 
Thr Lys His Lys Thr Ile His Thr Gly Lys Lys Pro Tyr Lys Cys Lys
225                 230                 235                 240 
Glu Cys Gly Lys Ala Phe Asn His Cys Ser Leu Leu Thr Ile His Glu
                245                 250                 255     
Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys
            260                 265                 270         
Ala Phe Asn Ser Ser Ser Ile Leu Thr Glu His Lys Val Ile His Ser
        275                 280                 285             
Gly Glu Lys Pro Tyr Lys Cys Glu Lys Cys Asp Lys Val Phe Lys Arg
    290                 295                 300                 
Phe Ser Tyr Leu Thr Lys His Lys Arg Ile His Thr Gly Glu Lys Pro
305                 310                 315                 320 
Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Trp Ser Ser Ile Leu
                325                 330                 335     
Thr Glu His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Asn Cys Glu
            340                 345                 350         
Glu Cys Gly Lys Ala Phe Asn Arg Cys Ser His Leu Leu Asp Ile Arg
        355                 360                 365             
Lys Phe Ile Leu Pro Ser Asn Ala Ile Asn Val Lys Asn Val Ala Lys
    370                 375                 380                 
Leu Leu Asn Gly Ala His Ile Leu Met Asn Ile Arg Glu Phe Lys Glu
385                 390                 395                 400 
Glu Arg Asn Pro Ala Ser Ile Lys Asn Val Gly Lys Leu Leu Ile Thr
                405                 410                 415     
Ala Gln Thr Leu Leu Arg Lys Asn Phe Tyr
            420                 425     


<210> 1798
<211> 479
<212> PRT
<213> Homo sapiens

<400> 1798
Met Ile Met His Asn Gly Asp Gly Thr Tyr Lys Cys Lys Phe Cys Gly
 1               5                  10                  15      
Lys Ala Cys Pro Cys Leu Ser Ile Tyr Leu Ile His Glu Arg Val His
            20                  25                  30          
Thr Gly Glu Lys Pro Tyr Lys Cys Lys Gln Cys Gly Lys Ala Phe Ser
        35                  40                  45              
Tyr Ser Thr Ser Leu Gln Ile His Glu Arg Thr His Thr Gly Glu Lys
    50                  55                  60                  
Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Gly Ser Pro Asn Ser
65                  70                  75                  80  
Leu Tyr Glu His Arg Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys
                85                  90                  95      
Lys Gln Cys Gly Lys Ala Phe Arg Trp Phe His Ser Phe Gln Ile His
            100                 105                 110         
Glu Arg Thr His Ser Glu Glu Lys Ala Tyr Glu Cys Thr Lys Cys Gly
        115                 120                 125             
Lys Ala Phe Lys Cys Pro Ser Tyr Leu Cys Arg His Glu Val Thr His
    130                 135                 140                 
Ser Gly Lys Lys Pro Cys Glu Cys Lys Gln Cys Gly Lys Ala Leu Ser
145                 150                 155                 160 
Tyr Leu Asn Phe Gln Arg His Met Lys Met His Thr Arg Met Arg Pro
                165                 170                 175     
Tyr Lys Cys Lys Thr Val Glu Lys Pro Leu Ile Leu Pro Val Arg Phe
            180                 185                 190         
Glu Ala Met Lys Glu Leu Thr Leu Glu Arg Asn Leu Met Asn Ala Ser
        195                 200                 205             
Thr Val Val Lys Pro Ser Ile Val Pro Val Pro Phe Thr Ile Met Lys
    210                 215                 220                 
Gly Leu Thr Leu Glu Arg Asn Pro Met Asn Val Ser Ser Val Val Lys
225                 230                 235                 240 
Pro Ser Phe Leu Pro Leu Pro Phe Asp Ile Met Lys Gly Leu Thr Leu
                245                 250                 255     
Glu Arg Asn Arg Met Ser Val Ser Asn Val Gly Lys Pro Ser Asp Leu
            260                 265                 270         
Pro His Thr Phe Lys Cys Met Glu Gly Leu Thr Leu Lys Arg Asn Pro
        275                 280                 285             
Met Asn Val Ser Ser Val Val Lys Pro Ser Phe Phe Pro Leu Pro Phe
    290                 295                 300                 
Asp Ile Met Lys Gly Leu Thr Leu Glu Arg Asn Pro Met Ser Val Ser
305                 310                 315                 320 
Asn Val Gly Lys Pro Ser His Leu Pro His Thr Phe Lys Cys Met Lys
                325                 330                 335     
Gly Leu Thr Leu Glu Ser Asn Cys Met Asn Leu Asn Asn Val Lys Lys
            340                 345                 350         
Pro Leu Asp Leu Ser Glu Thr Phe Lys Phe Met Lys Arg His Thr Leu
        355                 360                 365             
Glu Arg Asn Pro Ile Arg Asn Met Glu Lys His Ser Thr Ile Ser Leu
    370                 375                 380                 
Pro Phe Lys Tyr Met Gln Gln Cys Thr Glu Asp Arg Met Pro Met Asn
385                 390                 395                 400 
Val Lys Ser Val Thr Lys His Ser Tyr Leu Pro Arg Ser Phe Glu Tyr
                405                 410                 415     
Met Gln Glu His Thr Leu Glu Arg Asn Pro Met Asn Val Arg Asn Ala
            420                 425                 430         
Glu Lys Arg Ser Ile Ile Phe Leu Leu Tyr Val Tyr Thr Lys Gly Cys
        435                 440                 445             
Thr Leu Glu Arg Asn His Ile Asn Val Arg Ile Val Gly Lys His Ser
    450                 455                 460                 
Val Cys Leu Val Pro Phe Val Asp Ile Lys Gly Leu Thr Leu Glu
465                 470                 475                 


<210> 1799
<211> 911
<212> PRT
<213> Homo sapiens

<400> 1799
Met Ala Asp Gly Gly Gly Pro Lys Glu Ala Pro Ser Leu Arg Ser Ser
 1               5                  10                  15      
Pro Gly Pro Ala Pro Arg Val Pro Arg Ala Val Gly Pro Ser Gly Gly
            20                  25                  30          
Gly Gly Glu Thr Pro Arg Thr Ala Ala Leu Ala Leu Arg Phe Asp Lys
        35                  40                  45              
Pro Ile Lys Gln Ala Phe Tyr Asn Thr Gly Ala Val Leu Phe Val Cys
    50                  55                  60                  
Leu Cys Cys Gly Ala Ala Val Leu Val Tyr Phe Ile Leu Glu Ala Phe
65                  70                  75                  80  
Leu Arg Pro Leu Leu Trp Ala Val Leu Cys Gly Thr Phe Leu His Pro
                85                  90                  95      
Phe Lys Ser Ser Leu Thr Arg Leu Gly Arg His Trp Leu Gln Arg Leu
            100                 105                 110         
His Arg Ala His Thr Pro Ile Val Leu Ala Ala Leu Leu Leu Pro Leu
        115                 120                 125             
Cys Phe Val Asp Tyr Gly Val Glu Ala Leu Gly Glu Gln Ala Leu Arg
    130                 135                 140                 
Arg Arg Arg Leu Leu Leu Leu Leu Gly Ala Gly Gly Pro Leu Leu Tyr
145                 150                 155                 160 
Gly Leu Tyr Cys Leu Gly Ser Tyr Leu Gly Val Gln Val Leu Leu Val
                165                 170                 175     
His Ala Ala Thr Leu Ile Cys Arg Gly Leu Asp Tyr Phe Ser Ser Leu
            180                 185                 190         
Trp Ile Trp Thr Leu Val Val Gly Tyr Val Leu Thr Val Ser Phe Lys
        195                 200                 205             
Trp Asn Ala Ser Thr Glu Arg Tyr Leu Arg Ala Val Ser Ile Pro Val
    210                 215                 220                 
Trp Ile Ile Leu Leu Phe His Leu Ala Ser Leu Ala Gly Ser Trp Arg
225                 230                 235                 240 
Ile Pro Val Phe Leu Val Ile Val Phe Leu Met Ser Val Gly Thr Leu
                245                 250                 255     
Tyr Glu Lys Gln Asn Gly Lys Glu Ser Ser Gly Ala Glu Leu Pro Gly
            260                 265                 270         
Gln Val Ile Ser Met Ala Ala Ser Thr Leu Ala Asn Leu Ala Ile Ser
        275                 280                 285             
Ile Thr Gly Tyr Glu Ser Ser Ser Glu Asp Gln Pro Ser Thr Gln Pro
    290                 295                 300                 
Ala Glu Ala Val Asp Arg Gly Glu Ser Ala Pro Thr Leu Ser Thr Ser
305                 310                 315                 320 
Pro Ser Pro Ser Ser Pro Ser Pro Thr Ser Pro Ser Pro Thr Leu Gly
                325                 330                 335     
Arg Arg Arg Pro Glu Ile Gly Thr Phe Leu Arg Lys Lys Lys Thr Ser
            340                 345                 350         
Asp Ile Tyr Phe Val Ser Leu Val Trp Ala Ile Val Val Met Gln Ile
        355                 360                 365             
Trp Leu Asn Leu Trp Ile Val Gln Leu Leu Pro Val Pro Ile Ala Val
    370                 375                 380                 
Trp Ile Leu Lys Lys Leu Val Ile His Phe Gly Val Val Asp Phe Leu
385                 390                 395                 400 
Glu Lys Arg Tyr His Val Trp Trp Gly Ile Ile Glu Ser Phe Leu Lys
                405                 410                 415     
Glu Arg Gln Gly Ala Leu Ala Pro Trp Pro Ile Val Gly Leu Gly Lys
            420                 425                 430         
Phe Leu Leu Lys Val Asp Ser Lys Leu Trp His Trp Leu Asn Lys Lys
        435                 440                 445             
Met Ile Ile Trp Leu Glu Lys Met Leu Asp Lys Ile Ile Ser Ile Phe
    450                 455                 460                 
Ile Ile Phe Leu Leu Val Ile Gly Thr Leu Leu Leu Ala Leu Leu Leu
465                 470                 475                 480 
Thr Ala Lys Val His Gln Glu Ser Val His Met Ile Glu Val Thr Ser
                485                 490                 495     
Asn Leu Ile Asn Glu Thr Leu Ala Asn His Pro Glu Trp Ala Asn Trp
            500                 505                 510         
Leu Pro Glu Ala Gln Val Val Gln Arg Ala Leu Asn Ser Ala Ala Asn
        515                 520                 525             
Asn Val Tyr Gln Tyr Gly Arg Glu Trp Ile Thr His Lys Leu His Lys
    530                 535                 540                 
Ile Leu Gly Asp Lys Val Asn Asn Thr Ala Val Ile Glu Lys Gln Val
545                 550                 555                 560 
Leu Glu Leu Trp Asp Arg Leu Tyr His Ser Trp Phe Val Lys Asn Val
                565                 570                 575     
Thr His Ser Gly Arg His Lys Gly Gln Lys Leu His Val Ser Arg Gln
            580                 585                 590         
Asn Ser Trp Leu Gly Asp Ile Leu Asp Trp Gln Asp Ile Val Ser Phe
        595                 600                 605             
Val His Glu Asn Ile Glu Thr Phe Leu Ser Ile Leu Glu Ser Leu Trp
    610                 615                 620                 
Ile Val Met Ser Arg Asn Val Ser Leu Leu Phe Thr Thr Val Thr Thr
625                 630                 635                 640 
Leu Leu Thr Ile Leu Phe Tyr Ser Gly Thr Ala Leu Leu Asn Phe Val
                645                 650                 655     
Leu Ser Leu Ile Ile Phe Leu Thr Thr Leu Phe Tyr Leu Leu Ser Ser
            660                 665                 670         
Ser Asp Glu Tyr Tyr Lys Pro Val Lys Trp Val Ile Ser Leu Thr Pro
        675                 680                 685             
Leu Ser Gln Pro Gly Pro Ser Ser Asn Ile Ile Gly Gln Ser Val Glu
    690                 695                 700                 
Glu Ala Ile Arg Gly Val Phe Asp Ala Ser Leu Lys Met Ala Gly Phe
705                 710                 715                 720 
Tyr Gly Leu Tyr Thr Trp Leu Thr His Thr Met Phe Gly Ile Asn Ile
                725                 730                 735     
Val Phe Ile Pro Ser Ala Leu Ala Ala Ile Leu Gly Ala Val Pro Phe
            740                 745                 750         
Leu Gly Thr Tyr Trp Ala Ala Val Pro Ala Val Leu Asp Leu Trp Leu
        755                 760                 765             
Thr Gln Gly Leu Gly Cys Lys Ala Ile Leu Leu Leu Ile Phe His Leu
    770                 775                 780                 
Leu Pro Thr Tyr Phe Val Asp Thr Ala Ile Tyr Ser Asp Ile Ser Gly
785                 790                 795                 800 
Gly Gly His Pro Tyr Leu Thr Gly Leu Ala Val Ala Gly Gly Ala Tyr
                805                 810                 815     
Tyr Leu Gly Leu Glu Gly Ala Ile Ile Gly Pro Ile Leu Leu Cys Ile
            820                 825                 830         
Leu Val Val Ala Ser Asn Ile Tyr Ser Ala Met Leu Val Ser Pro Thr
        835                 840                 845             
Asn Ser Val Pro Thr Pro Asn Gln Thr Pro Trp Pro Ala Gln Pro Gln
    850                 855                 860                 
Arg Thr Phe Arg Asp Ile Ser Glu Arg Ser Glu Ile Phe Ser Lys Val
865                 870                 875                 880 
Asp Val Val Ser Ser Ala Val Ile Phe Leu Arg Lys Phe Lys Phe Asp
                885                 890                 895     
Ser Glu Phe Ser Ser Ala Val Ala Phe Cys Pro Ser Ser Cys Ala
            900                 905                 910     


<210> 1800
<211> 563
<212> PRT
<213> Homo sapiens

<400> 1800
Met Leu Leu Pro Ala Pro Ala Leu Arg Arg Ala Leu Leu Ser Arg Pro
 1               5                  10                  15      
Trp Thr Gly Ala Gly Leu Arg Trp Lys His Thr Ser Ser Leu Lys Val
            20                  25                  30          
Ala Asn Glu Pro Val Leu Ala Phe Thr Gln Gly Ser Pro Glu Arg Asp
        35                  40                  45              
Ala Leu Gln Lys Ala Leu Lys Asp Leu Lys Gly Arg Met Glu Ala Ile
    50                  55                  60                  
Pro Cys Val Val Gly Asp Glu Glu Val Trp Thr Ser Asp Val Gln Tyr
65                  70                  75                  80  
Gln Val Ser Pro Phe Asn His Gly His Lys Val Ala Lys Phe Cys Tyr
                85                  90                  95      
Ala Asp Lys Ser Leu Leu Asn Lys Ala Ile Glu Ala Ala Leu Ala Ala
            100                 105                 110         
Arg Lys Glu Trp Asp Leu Lys Pro Ile Ala Asp Arg Ala Gln Ile Phe
        115                 120                 125             
Leu Lys Ala Ala Asp Met Leu Ser Gly Pro Arg Arg Ala Glu Ile Leu
    130                 135                 140                 
Ala Lys Thr Met Val Gly Gln Gly Lys Thr Val Ile Gln Ala Glu Ile
145                 150                 155                 160 
Asp Ala Ala Ala Glu Leu Ile Asp Phe Phe Arg Phe Asn Ala Lys Tyr
                165                 170                 175     
Ala Val Glu Leu Glu Gly Gln Gln Pro Ile Ser Val Pro Pro Ser Thr
            180                 185                 190         
Asn Ser Thr Val Tyr Arg Gly Leu Glu Gly Phe Val Ala Ala Ile Ser
        195                 200                 205             
Pro Phe Asn Phe Thr Ala Ile Gly Gly Asn Leu Ala Gly Ala Pro Ala
    210                 215                 220                 
Leu Met Gly Asn Val Val Leu Trp Lys Pro Ser Asp Thr Ala Met Leu
225                 230                 235                 240 
Ala Ser Tyr Ala Val Tyr Arg Ile Leu Arg Glu Ala Gly Leu Pro Pro
                245                 250                 255     
Asn Ile Ile Gln Phe Val Pro Ala Asp Gly Pro Leu Phe Gly Asp Thr
            260                 265                 270         
Val Thr Ser Ser Glu His Leu Cys Gly Ile Asn Phe Thr Gly Ser Val
        275                 280                 285             
Pro Thr Phe Lys His Leu Trp Lys Gln Val Ala Gln Asn Leu Asp Arg
    290                 295                 300                 
Phe His Thr Phe Pro Arg Leu Ala Gly Glu Cys Gly Gly Lys Asn Phe
305                 310                 315                 320 
His Phe Val His Arg Ser Ala Asp Val Glu Ser Val Val Ser Gly Thr
                325                 330                 335     
Leu Arg Ser Ala Phe Glu Tyr Gly Gly Gln Lys Cys Ser Ala Cys Ser
            340                 345                 350         
Arg Leu Tyr Val Pro His Ser Leu Trp Pro Gln Ile Lys Gly Arg Leu
        355                 360                 365             
Leu Glu Glu His Ser Arg Ile Lys Val Gly Asp Pro Ala Glu Asp Phe
    370                 375                 380                 
Gly Thr Phe Phe Ser Ala Val Ile Asp Ala Lys Ser Phe Ala Arg Ile
385                 390                 395                 400 
Lys Lys Trp Leu Glu His Ala Arg Ser Ser Pro Ser Leu Thr Ile Leu
                405                 410                 415     
Ala Gly Gly Lys Cys Asp Asp Ser Val Gly Tyr Phe Val Glu Pro Cys
            420                 425                 430         
Ile Val Glu Ser Lys Asp Pro Gln Glu Pro Ile Met Lys Glu Glu Ile
        435                 440                 445             
Phe Gly Pro Val Leu Ser Val Tyr Val Tyr Pro Asp Asp Lys Tyr Lys
    450                 455                 460                 
Glu Thr Leu Gln Leu Ile Asp Ser Thr Thr Ser Tyr Gly Leu Thr Gly
465                 470                 475                 480 
Ala Val Phe Ser Gln Asp Lys Asp Val Val Gln Glu Ala Thr Lys Val
                485                 490                 495     
Leu Arg Asn Ala Ala Gly Asn Phe Tyr Ile Asn Asp Lys Ser Thr Gly
            500                 505                 510         
Ser Ile Val Gly Gln Gln Pro Phe Gly Gly Ala Arg Ala Ser Gly Thr
        515                 520                 525             
Asn Asp Lys Pro Gly Gly Pro His Tyr Ile Leu Arg Trp Thr Ser Pro
    530                 535                 540                 
Gln Val Ile Lys Glu Thr His Lys Pro Leu Gly Asp Trp Ser Tyr Ala
545                 550                 555                 560 
Tyr Met Gln
            


<210> 1801
<211> 1029
<212> PRT
<213> Homo sapiens

<400> 1801
Glu Asn Leu Thr Tyr Arg Gln Leu Leu Glu Arg Cys Val Glu Asp Pro
 1               5                  10                  15      
Glu Thr Gly Leu Arg Leu Leu Pro Leu Lys Gly Ala Glu Lys Ala Glu
            20                  25                  30          
Val Val Glu Thr Thr Gln Val Tyr Thr Glu Glu Glu Thr Arg Arg Ala
        35                  40                  45              
Phe Glu Glu Thr Gln Ile Asp Ile Pro Gly Gly Gly Ser His Gly Gly
    50                  55                  60                  
Ser Thr Met Ser Leu Trp Glu Val Met Gln Ser Asp Leu Ile Pro Glu
65                  70                  75                  80  
Glu Gln Arg Ala Gln Leu Met Ala Asp Phe Gln Ala Gly Arg Val Thr
                85                  90                  95      
Lys Glu Arg Met Ile Ile Ile Ile Ile Glu Ile Ile Glu Lys Thr Glu
            100                 105                 110         
Ile Ile Arg Gln Gln Gly Leu Ala Ser Tyr Asp Tyr Val Arg Arg Arg
        115                 120                 125             
Leu Thr Ala Glu Asp Leu Phe Glu Ala Arg Ile Ile Ser Leu Glu Thr
    130                 135                 140                 
Tyr Asn Leu Leu Arg Glu Gly Thr Arg Ser Leu Arg Glu Ala Leu Glu
145                 150                 155                 160 
Ala Glu Ser Ala Trp Cys Tyr Leu Tyr Gly Thr Gly Ser Val Ala Gly
                165                 170                 175     
Val Tyr Leu Pro Gly Ser Arg Gln Thr Leu Ser Ile Tyr Gln Ala Leu
            180                 185                 190         
Lys Lys Gly Leu Leu Ser Ala Glu Val Ala Arg Leu Leu Leu Glu Ala
        195                 200                 205             
Gln Ala Ala Thr Gly Phe Leu Leu Asp Pro Val Lys Gly Glu Arg Leu
    210                 215                 220                 
Thr Val Asp Glu Ala Val Arg Lys Gly Leu Val Gly Pro Glu Leu His
225                 230                 235                 240 
Asp Arg Leu Leu Ser Ala Glu Arg Ala Val Thr Gly Tyr Arg Asp Pro
                245                 250                 255     
Tyr Thr Glu Gln Thr Ile Ser Leu Phe Gln Ala Met Lys Lys Glu Leu
            260                 265                 270         
Ile Pro Thr Glu Glu Ala Leu Arg Leu Leu Asp Ala Gln Leu Ala Thr
        275                 280                 285             
Gly Gly Ile Val Asp Pro Arg Leu Gly Phe His Leu Pro Leu Glu Val
    290                 295                 300                 
Ala Tyr Gln Arg Gly Tyr Leu Asn Lys Asp Thr His Asp Gln Leu Ser
305                 310                 315                 320 
Glu Pro Ser Glu Val Arg Ser Tyr Val Asp Pro Ser Thr Asp Glu Arg
                325                 330                 335     
Leu Ser Tyr Thr Gln Leu Leu Arg Arg Cys Arg Arg Asp Asp Gly Thr
            340                 345                 350         
Gly Gln Leu Leu Leu Pro Leu Ser Asp Ala Arg Lys Leu Thr Phe Arg
        355                 360                 365             
Gly Leu Arg Lys Gln Ile Thr Met Glu Glu Leu Val Arg Ser Gln Val
    370                 375                 380                 
Met Asp Glu Ala Thr Ala Leu Gln Leu Arg Glu Gly Leu Thr Ser Ile
385                 390                 395                 400 
Glu Glu Val Thr Lys Asn Leu Gln Lys Phe Leu Glu Gly Thr Ser Cys
                405                 410                 415     
Ile Ala Gly Val Phe Val Asp Ala Thr Lys Glu Arg Leu Ser Val Tyr
            420                 425                 430         
Gln Ala Met Lys Lys Gly Ile Ile Arg Pro Gly Thr Ala Phe Glu Leu
        435                 440                 445             
Leu Glu Ala Gln Ala Ala Thr Gly Tyr Val Ile Asp Pro Ile Lys Gly
    450                 455                 460                 
Leu Lys Leu Thr Val Glu Glu Ala Val Arg Met Gly Ile Val Gly Pro
465                 470                 475                 480 
Glu Phe Lys Asp Lys Leu Leu Ser Ala Glu Arg Ala Val Thr Gly Tyr
                485                 490                 495     
Lys Asp Pro Tyr Ser Gly Lys Leu Ile Ser Leu Phe Gln Ala Met Lys
            500                 505                 510         
Lys Gly Leu Ile Leu Lys Asp His Gly Ile Arg Leu Leu Glu Ala Gln
        515                 520                 525             
Ile Ala Thr Gly Gly Ile Ile Asp Pro Glu Glu Ser His Arg Leu Pro
    530                 535                 540                 
Val Glu Val Ala Tyr Lys Arg Gly Leu Phe Asp Glu Glu Met Asn Glu
545                 550                 555                 560 
Ile Leu Thr Asp Pro Ser Asp Asp Thr Lys Gly Phe Phe Asp Pro Asn
                565                 570                 575     
Thr Glu Glu Asn Leu Thr Tyr Leu Gln Leu Met Glu Arg Cys Ile Thr
            580                 585                 590         
Asp Pro Gln Thr Gly Leu Cys Leu Leu Pro Leu Lys Glu Lys Lys Arg
        595                 600                 605             
Glu Arg Lys Thr Ser Ser Lys Ser Ser Val Arg Lys Arg Arg Val Val
    610                 615                 620                 
Ile Val Asp Pro Glu Thr Gly Lys Glu Met Ser Val Tyr Glu Ala Tyr
625                 630                 635                 640 
Arg Lys Gly Leu Ile Asp His Gln Thr Tyr Leu Glu Leu Ser Glu Gln
                645                 650                 655     
Glu Cys Glu Trp Glu Glu Ile Thr Ile Ser Ser Ser Asp Gly Val Val
            660                 665                 670         
Lys Ser Met Ile Ile Asp Arg Arg Ser Gly Arg Gln Tyr Asp Ile Asp
        675                 680                 685             
Asp Ala Ile Ala Lys Asn Leu Ile Asp Arg Ser Ala Leu Asp Gln Tyr
    690                 695                 700                 
Arg Ala Gly Thr Leu Ser Ile Thr Glu Phe Ala Asp Met Leu Ser Gly
705                 710                 715                 720 
Asn Ala Gly Gly Phe Arg Ser Arg Ser Ser Ser Val Gly Ser Ser Ser
                725                 730                 735     
Ser Tyr Pro Ile Ser Pro Ala Val Ser Arg Thr Gln Leu Ala Ser Trp
            740                 745                 750         
Ser Asp Pro Thr Glu Glu Thr Gly Pro Val Ala Gly Ile Leu Asp Thr
        755                 760                 765             
Glu Thr Leu Glu Lys Val Ser Ile Thr Glu Ala Met His Arg Asn Leu
    770                 775                 780                 
Val Asp Asn Ile Thr Gly Gln Arg Leu Leu Glu Ala Gln Ala Cys Thr
785                 790                 795                 800 
Gly Gly Ile Ile Asp Pro Ser Thr Gly Glu Arg Phe Pro Val Thr Asp
                805                 810                 815     
Ala Val Asn Lys Gly Leu Val Asp Lys Ile Met Val Asp Arg Ile Asn
            820                 825                 830         
Leu Ala Gln Lys Ala Phe Cys Gly Phe Glu Asp Pro Arg Thr Lys Thr
        835                 840                 845             
Lys Met Ser Ala Ala Gln Ala Leu Lys Lys Gly Trp Leu Tyr Tyr Glu
    850                 855                 860                 
Ala Gly Gln Arg Phe Leu Glu Val Gln Tyr Leu Thr Gly Gly Leu Ile
865                 870                 875                 880 
Glu Pro Asp Thr Pro Gly Arg Val Pro Leu Asp Glu Ala Leu Gln Arg
                885                 890                 895     
Gly Thr Val Asp Ala Arg Thr Ala Gln Lys Leu Arg Asp Val Gly Ala
            900                 905                 910         
Tyr Ser Lys Tyr Leu Thr Cys Pro Lys Thr Lys Leu Lys Ile Ser Tyr
        915                 920                 925             
Lys Asp Ala Leu Asp Arg Ser Met Val Glu Glu Gly Thr Gly Leu Arg
    930                 935                 940                 
Leu Leu Glu Ala Ala Ala Gln Ser Thr Lys Gly Tyr Tyr Ser Pro Tyr
945                 950                 955                 960 
Ser Val Ser Gly Ser Gly Ser Thr Ala Gly Ser Arg Thr Gly Ser Arg
                965                 970                 975     
Thr Gly Ser Arg Ala Gly Ser Arg Arg Gly Ser Phe Asp Ala Thr Gly
            980                 985                 990         
Ser Gly Phe Ser Met Thr Phe Ser Ser Ser Ser Tyr Ser Ser Ser Gly
        995                 1000                1005            
Tyr Gly Arg Arg Tyr Ala Ser Gly Ser Ser Ala Ser Leu Gly Gly Pro
    1010                1015                1020                
Glu Ser Ala Val Ala
1025                


<210> 1802
<211> 580
<212> PRT
<213> Homo sapiens

<400> 1802
Arg Cys Leu Asn Pro Ala Leu Gly Asn Leu Thr Ala Leu Thr Tyr Leu
 1               5                  10                  15      
Asn Leu Ser Arg Asn Gln Leu Ser Leu Leu Pro Pro Tyr Ile Cys Gln
            20                  25                  30          
Leu Pro Leu Arg Val Leu Ile Val Ser Asn Asn Lys Leu Gly Ala Leu
        35                  40                  45              
Pro Pro Asp Ile Gly Thr Leu Gly Ser Leu Arg Gln Leu Asp Val Ser
    50                  55                  60                  
Ser Asn Glu Leu Gln Ser Leu Pro Ser Glu Leu Cys Gly Leu Ser Ser
65                  70                  75                  80  
Leu Arg Asp Leu Asn Val Arg Arg Asn Gln Leu Ser Thr Leu Pro Glu
                85                  90                  95      
Glu Leu Gly Asp Leu Pro Leu Val Arg Leu Asp Phe Ser Cys Asn Arg
            100                 105                 110         
Val Ser Arg Ile Pro Val Ser Phe Cys Arg Leu Arg His Leu Gln Val
        115                 120                 125             
Ile Leu Leu Asp Ser Asn Pro Leu Gln Ser Pro Pro Ala Gln Val Cys
    130                 135                 140                 
Leu Lys Gly Lys Leu His Ile Phe Lys Tyr Leu Ser Thr Glu Ala Gly
145                 150                 155                 160 
Gln Arg Gly Ser Ala Leu Gly Asp Leu Ala Pro Ser Arg Pro Pro Ser
                165                 170                 175     
Phe Ser Pro Cys Pro Ala Glu Asp Leu Phe Pro Gly His Arg Tyr Asp
            180                 185                 190         
Gly Gly Leu Asp Ser Gly Phe His Ser Val Asp Ser Gly Ser Lys Arg
        195                 200                 205             
Trp Ser Gly Asn Glu Ser Thr Asp Glu Phe Ser Glu Leu Ser Phe Arg
    210                 215                 220                 
Ile Ser Glu Leu Ala Arg Glu Pro Arg Gly Pro Arg Glu Arg Lys Glu
225                 230                 235                 240 
Asp Gly Ser Ala Asp Gly Asp Pro Val Gln Ile Asp Phe Ile Asp Ser
                245                 250                 255     
His Val Pro Gly Glu Asp Glu Glu Arg Gly Thr Val Glu Glu Gln Arg
            260                 265                 270         
Pro Pro Glu Leu Ser Pro Gly Ala Gly Asp Arg Glu Arg Ala Pro Ser
        275                 280                 285             
Ser Arg Arg Glu Glu Pro Ala Gly Glu Glu Arg Arg Arg Pro Asp Thr
    290                 295                 300                 
Leu Gln Leu Trp Gln Glu Arg Glu Arg Arg Gln Gln Gln Gln Ser Gly
305                 310                 315                 320 
Ala Trp Gly Ala Pro Arg Lys Asp Ser Leu Leu Lys Pro Gly Leu Arg
                325                 330                 335     
Ala Val Val Gly Gly Ala Ala Ala Val Ser Thr Gln Ala Met His Asn
            340                 345                 350         
Gly Ser Pro Lys Ser Ser Ala Ser Gln Ala Gly Ala Ala Ala Gly Gln
        355                 360                 365             
Gly Ala Pro Ala Pro Ala Pro Ala Ser Gln Glu Pro Leu Pro Ile Ala
    370                 375                 380                 
Gly Pro Ala Thr Ala Pro Ala Pro Arg Pro Leu Gly Ser Ile Gln Arg
385                 390                 395                 400 
Pro Asn Ser Phe Leu Phe Arg Ser Ser Ser Gln Ser Gly Ser Gly Pro
                405                 410                 415     
Ser Ser Pro Asp Ser Val Leu Arg Pro Arg Arg Tyr Pro Gln Val Pro
            420                 425                 430         
Asp Glu Lys Asp Leu Met Thr Gln Leu Arg Gln Val Leu Glu Ser Arg
        435                 440                 445             
Leu Gln Arg Pro Leu Pro Glu Asp Leu Ala Glu Ala Leu Ala Ser Gly
    450                 455                 460                 
Val Ile Leu Cys Gln Leu Ala Asn Gln Leu Arg Pro Arg Ser Val Pro
465                 470                 475                 480 
Phe Ile His Val Pro Ser Pro Ala Val Pro Lys Leu Ser Ala Leu Lys
                485                 490                 495     
Ala Arg Lys Asn Val Glu Ser Phe Leu Glu Ala Cys Arg Lys Met Gly
            500                 505                 510         
Val Pro Glu Ala Asp Leu Cys Ser Pro Ser Asp Leu Leu Gln Gly Thr
        515                 520                 525             
Ala Arg Gly Leu Arg Thr Ala Leu Glu Ala Met Lys Arg Val Gly Gly
    530                 535                 540                 
Lys Ala Leu Pro Pro Leu Trp Pro Pro Ser Gly Leu Gly Gly Phe Val
545                 550                 555                 560 
Val Phe Tyr Val Val Leu Met Leu Leu Leu Tyr Val Thr Tyr Thr Arg
                565                 570                 575     
Leu Leu Gly Ser
            580 


<210> 1803
<211> 554
<212> PRT
<213> Homo sapiens

<400> 1803
Trp Glu Trp Ser Gly Gly Ser Val Val Met Trp Leu Asp Arg Arg Gly
 1               5                  10                  15      
Trp Leu Arg Val Leu Gly His Trp Arg Tyr Asp Leu Arg Arg Pro Ser
            20                  25                  30          
Phe Thr Arg Thr Trp Ser Gly Asp Lys Gly Pro Met Ala Glu Thr Val
        35                  40                  45              
Ser Thr Gln Val Gly Thr Glu Gly Gly Leu Arg Ala Ser His Gln Gln
    50                  55                  60                  
Asn Gly Asp Ala Gly Gly Asp Ala Lys Val Glu Leu Ser Pro Gly Pro
65                  70                  75                  80  
Pro Lys Pro Ala Gly Arg Glu Val Glu Pro Ala Pro Val Gly Gly Glu
                85                  90                  95      
His Pro Ser Ala Ala Ala Pro Gly Pro Gly Lys His Lys Lys Arg Arg
            100                 105                 110         
Gly Ala Thr Arg Glu Arg Val Val Pro Pro Pro Lys Lys Arg Arg Thr
        115                 120                 125             
Gly Val Ser Phe Gly Asp Glu His Phe Ala Glu Thr Ser Tyr Tyr Phe
    130                 135                 140                 
Glu Gly Gly Leu Arg Lys Val Arg Pro Tyr Tyr Phe Asp Phe Arg Thr
145                 150                 155                 160 
Tyr Cys Lys Gly Arg Trp Val Gly His Ser Leu Leu His Val Phe Ser
                165                 170                 175     
Thr Glu Phe Arg Ala Gln Pro Leu Ala Tyr Tyr Glu Ala Ala Val Arg
            180                 185                 190         
Ala Gly Arg Leu Gln Leu Asn Glu Lys Pro Val Gln Asp Leu Asn Ile
        195                 200                 205             
Val Leu Lys Asp Asn Asp Phe Leu Arg Asn Thr Val His Arg His Glu
    210                 215                 220                 
Pro Pro Val Thr Ala Glu Pro Ile Arg Leu Leu Ala Glu Asn Glu Asp
225                 230                 235                 240 
Val Val Val Val Asp Lys Pro Ser Ser Ile Pro Val His Pro Cys Gly
                245                 250                 255     
Arg Phe Arg His Asn Thr Val Ile Phe Ile Leu Gly Lys Glu His Gln
            260                 265                 270         
Leu Lys Glu Leu His Pro Leu His Arg Leu Asp Arg Leu Thr Ser Gly
        275                 280                 285             
Val Leu Met Phe Ala Lys Thr Ala Ala Val Ser Glu Arg Ile His Glu
    290                 295                 300                 
Gln Val Arg Asp Arg Gln Leu Glu Lys Glu Tyr Val Cys Arg Val Glu
305                 310                 315                 320 
Gly Glu Phe Pro Thr Glu Glu Val Thr Cys Lys Glu Pro Ile Leu Val
                325                 330                 335     
Val Ser Tyr Lys Val Gly Val Cys Arg Val Asp Pro Arg Gly Lys Pro
            340                 345                 350         
Cys Glu Thr Val Phe Gln Arg Leu Ser Tyr Asn Gly Gln Ser Ser Val
        355                 360                 365             
Val Arg Cys Arg Pro Leu Thr Gly Arg Thr His Gln Ile Arg Val His
    370                 375                 380                 
Leu Gln Phe Leu Gly His Pro Ile Leu Asn Asp Pro Ile Tyr Asn Ser
385                 390                 395                 400 
Val Ala Trp Gly Pro Ser Arg Gly Arg Gly Gly Tyr Ile Pro Lys Thr
                405                 410                 415     
Asn Glu Glu Leu Leu Arg Asp Leu Val Ala Glu His Gln Ala Lys Gln
            420                 425                 430         
Ser Leu Asp Val Leu Asp Leu Cys Glu Gly Asp Leu Ser Pro Gly Leu
        435                 440                 445             
Thr Asp Ser Thr Ala Pro Ser Ser Glu Leu Gly Lys Asp Asp Leu Glu
    450                 455                 460                 
Glu Leu Ala Ala Ala Ala Gln Lys Met Glu Glu Val Ala Glu Ala Ala
465                 470                 475                 480 
Pro Gln Glu Leu Asp Thr Ile Ala Leu Ala Ser Glu Lys Ala Val Glu
                485                 490                 495     
Thr Asp Val Met Asn Gln Glu Thr Asp Pro Leu Cys Ala Glu Cys Arg
            500                 505                 510         
Leu Val Arg Gln Asp Pro Leu Pro Gln Asp Leu Val Met Phe Leu His
        515                 520                 525             
Ala Leu Arg Tyr Lys Gly Pro Gly Phe Glu Tyr Phe Ser Pro Met Pro
    530                 535                 540                 
Ala Trp Ala Gln Asp Asp Trp Gln Lys Asp
545                 550                 


<210> 1804
<211> 432
<212> PRT
<213> Homo sapiens

<400> 1804
Gly Thr Arg Pro Val Ala Ala Gln Ala Gly Lys Leu Leu Arg Ala Leu
 1               5                  10                  15      
Ala Leu Arg Pro Arg Phe Leu Ala Ala Gly Ser Gln Ala Val Gln Leu
            20                  25                  30          
Thr Ser Arg Arg Trp Leu Asn Leu Gln Glu Tyr Gln Ser Lys Lys Leu
        35                  40                  45              
Met Ser Asp Asn Gly Val Arg Val Gln Arg Phe Phe Val Ala Asp Thr
    50                  55                  60                  
Ala Asn Glu Ala Leu Glu Ala Ala Lys Arg Leu Asn Ala Lys Glu Ile
65                  70                  75                  80  
Val Leu Lys Ala Gln Ile Leu Ala Gly Gly Arg Gly Lys Gly Val Phe
                85                  90                  95      
Asn Ser Gly Leu Lys Gly Gly Val His Leu Thr Lys Asp Pro Asn Val
            100                 105                 110         
Val Gly Gln Leu Ala Lys Gln Met Ile Gly Tyr Asn Leu Ala Thr Lys
        115                 120                 125             
Gln Thr Pro Lys Glu Gly Val Lys Val Asn Lys Val Met Val Ala Glu
    130                 135                 140                 
Ala Leu Asp Ile Ser Arg Glu Thr Tyr Leu Ala Ile Leu Met Asp Arg
145                 150                 155                 160 
Ser Cys Asn Gly Pro Val Leu Val Gly Ser Pro Gln Gly Gly Val Asp
                165                 170                 175     
Ile Glu Glu Val Ala Ala Ser Asn Pro Glu Leu Ile Phe Lys Glu Gln
            180                 185                 190         
Ile Asp Ile Phe Glu Gly Ile Lys Asp Ser Gln Ala Gln Arg Met Ala
        195                 200                 205             
Glu Asn Leu Gly Phe Val Gly Pro Leu Lys Ser Gln Ala Ala Asp Gln
    210                 215                 220                 
Ile Thr Lys Leu Tyr Asn Leu Phe Leu Lys Ile Asp Ala Thr Gln Val
225                 230                 235                 240 
Glu Val Asn Pro Phe Gly Glu Thr Pro Glu Gly Gln Val Val Cys Phe
                245                 250                 255     
Asp Ala Lys Ile Asn Phe Asp Asp Asn Ala Glu Phe Arg Gln Lys Asp
            260                 265                 270         
Ile Phe Ala Met Asp Asp Lys Ser Glu Asn Glu Pro Ile Glu Asn Glu
        275                 280                 285             
Ala Ala Lys Tyr Asp Leu Lys Tyr Ile Gly Leu Asp Gly Asn Ile Ala
    290                 295                 300                 
Cys Phe Val Asn Gly Ala Gly Leu Ala Met Ala Thr Cys Asp Ile Ile
305                 310                 315                 320 
Phe Leu Asn Gly Gly Lys Pro Ala Asn Phe Leu Asp Leu Gly Gly Gly
                325                 330                 335     
Val Lys Glu Ala Gln Val Tyr Gln Ala Phe Lys Leu Leu Thr Ala Asp
            340                 345                 350         
Pro Lys Val Glu Ala Ile Leu Val Asn Ile Phe Gly Gly Ile Val Asn
        355                 360                 365             
Cys Ala Ile Ile Ala Asn Gly Ile Thr Lys Ala Cys Arg Glu Leu Glu
    370                 375                 380                 
Leu Lys Val Pro Leu Val Val Arg Leu Glu Gly Thr Asn Val Gln Glu
385                 390                 395                 400 
Ala Gln Lys Ile Leu Asn Asn Ser Gly Leu Pro Ile Thr Ser Ala Ile
                405                 410                 415     
Asp Leu Glu Asp Ala Ala Lys Lys Ala Val Ala Ser Val Ala Lys Lys
            420                 425                 430         


<210> 1805
<211> 750
<212> PRT
<213> Homo sapiens

<400> 1805
Ala Arg Gly His Glu Glu His His Ala Ala Lys Thr Leu Gly Ile Gly
 1               5                  10                  15      
Lys Ala Ile Ala Val Leu Thr Ser Gly Gly Asp Ala Gln Gly Met Asn
            20                  25                  30          
Ala Ala Val Arg Ala Val Val Arg Val Gly Ile Phe Thr Gly Ala Arg
        35                  40                  45              
Val Phe Phe Val His Glu Gly Tyr Gln Gly Leu Val Asp Gly Gly Asp
    50                  55                  60                  
His Ile Lys Glu Ala Thr Trp Glu Ser Val Ser Met Met Leu Gln Leu
65                  70                  75                  80  
Gly Gly Thr Val Ile Gly Ser Ala Arg Cys Lys Asp Phe Arg Glu Arg
                85                  90                  95      
Glu Gly Arg Leu Arg Ala Ala Tyr Asn Leu Val Lys Arg Gly Ile Thr
            100                 105                 110         
Asn Leu Cys Val Ile Gly Gly Asp Gly Ser Leu Thr Gly Ala Asp Thr
        115                 120                 125             
Phe Arg Ser Glu Trp Ser Asp Leu Leu Ser Asp Leu Gln Lys Ala Gly
    130                 135                 140                 
Lys Ile Thr Asp Glu Glu Ala Thr Lys Ser Ser Tyr Leu Asn Ile Val
145                 150                 155                 160 
Gly Leu Val Gly Ser Ile Asp Asn Asp Phe Cys Gly Thr Asp Met Thr
                165                 170                 175     
Ile Gly Thr Asp Ser Ala Leu His Arg Ile Met Glu Ile Val Asp Ala
            180                 185                 190         
Ile Thr Thr Thr Ala Gln Ser His Gln Arg Thr Phe Val Leu Glu Val
        195                 200                 205             
Met Gly Arg His Cys Gly Tyr Leu Ala Leu Val Thr Ser Leu Ser Cys
    210                 215                 220                 
Gly Ala Asp Trp Val Phe Ile Pro Glu Cys Pro Pro Asp Asp Asp Trp
225                 230                 235                 240 
Glu Glu His Leu Cys Arg Arg Leu Ser Glu Thr Arg Thr Arg Gly Ser
                245                 250                 255     
Arg Leu Asn Ile Ile Ile Val Ala Glu Gly Ala Ile Asp Lys Asn Gly
            260                 265                 270         
Lys Pro Ile Thr Ser Glu Asp Ile Lys Asn Gly Ser Arg Met Gly Val
        275                 280                 285             
Glu Ala Val Met Ala Leu Leu Glu Gly Thr Pro Asp Thr Pro Ala Cys
    290                 295                 300                 
Val Val Ser Leu Ser Gly Asn Gln Ala Val Arg Leu Pro Leu Met Glu
305                 310                 315                 320 
Cys Val Gln Val Thr Lys Asp Val Thr Lys Ala Met Asp Glu Lys Lys
                325                 330                 335     
Phe Asp Glu Ala Leu Lys Leu Arg Gly Arg Ser Phe Met Asn Asn Trp
            340                 345                 350         
Glu Val Tyr Lys Leu Leu Ala His Val Arg Pro Pro Val Ser Lys Ser
        355                 360                 365             
Gly Ser His Thr Val Ala Val Met Asn Val Gly Ala Pro Ala Ala Gly
    370                 375                 380                 
Met Asn Ala Ala Val Arg Ser Thr Val Arg Ile Gly Leu Ile Gln Gly
385                 390                 395                 400 
Asn Arg Val Leu Val Val His Asp Gly Phe Glu Gly Leu Ala Lys Gly
                405                 410                 415     
Gln Ile Glu Glu Ala Gly Trp Ser Tyr Val Gly Gly Trp Thr Gly Gln
            420                 425                 430         
Gly Gly Ser Lys Leu Gly Thr Lys Arg Thr Leu Pro Lys Lys Ser Phe
        435                 440                 445             
Glu Gln Ile Ser Ala Asn Ile Thr Lys Phe Asn Ile Gln Gly Leu Val
    450                 455                 460                 
Ile Ile Gly Gly Phe Glu Ala Tyr Thr Gly Gly Leu Glu Leu Met Glu
465                 470                 475                 480 
Gly Arg Lys Gln Phe Asp Glu Leu Cys Ile Pro Phe Val Val Ile Pro
                485                 490                 495     
Ala Thr Val Ser Asn Asn Val Pro Gly Ser Asp Phe Ser Val Gly Ala
            500                 505                 510         
Asp Thr Ala Leu Asn Thr Ile Cys Thr Thr Cys Asp Arg Ile Lys Gln
        515                 520                 525             
Ser Ala Ala Gly Thr Lys Arg Arg Val Phe Ile Ile Glu Thr Met Gly
    530                 535                 540                 
Gly Tyr Cys Gly Tyr Leu Ala Thr Met Ala Gly Leu Ala Ala Gly Ala
545                 550                 555                 560 
Asp Ala Ala Tyr Ile Phe Glu Glu Pro Phe Thr Ile Arg Asp Leu Gln
                565                 570                 575     
Ala Asn Val Glu His Leu Val Gln Lys Met Lys Thr Thr Val Lys Arg
            580                 585                 590         
Gly Leu Val Leu Arg Asn Glu Lys Cys Asn Glu Asn Tyr Thr Thr Asp
        595                 600                 605             
Phe Ile Phe Asn Leu Tyr Ser Glu Glu Gly Lys Gly Ile Phe Asp Ser
    610                 615                 620                 
Arg Lys Asn Val Leu Gly His Met Gln Gln Gly Gly Ser Pro Thr Pro
625                 630                 635                 640 
Phe Asp Arg Asn Phe Ala Thr Lys Met Gly Ala Lys Ala Met Asn Trp
                645                 650                 655     
Met Ser Gly Lys Ile Lys Glu Ser Tyr Arg Asn Gly Arg Ile Phe Ala
            660                 665                 670         
Asn Thr Pro Asp Ser Gly Cys Val Leu Gly Met Arg Lys Arg Ala Leu
        675                 680                 685             
Val Phe Gln Pro Val Ala Glu Leu Lys Asp Gln Thr Asp Phe Glu His
    690                 695                 700                 
Arg Ile Pro Lys Glu Gln Trp Trp Leu Lys Leu Arg Pro Ile Leu Lys
705                 710                 715                 720 
Ile Leu Ala Lys Tyr Glu Ile Asp Leu Asp Thr Ser Asp His Ala His
                725                 730                 735     
Leu Glu His Ile Thr Arg Lys Arg Ser Gly Glu Ala Ala Val
            740                 745                 750 


<210> 1806
<211> 586
<212> PRT
<213> Homo sapiens

<400> 1806
Met Ser Trp Leu Phe Gly Ile Asn Lys Gly Pro Lys Gly Glu Asp Ala
 1               5                  10                  15      
Gly Pro Pro Pro Pro Leu Pro Pro Ala Gln Pro Gly Ala Glu Gly Gly
            20                  25                  30          
Gly Asp Arg Gly Leu Gly Asp Arg Pro Ala Pro Lys Asp Lys Trp Ser
        35                  40                  45              
Asn Phe Asp Pro Thr Gly Leu Glu Arg Ala Ala Lys Ala Ala Arg Glu
    50                  55                  60                  
Leu Glu His Ser Arg Tyr Ala Lys Asp Ala Leu Asn Leu Ala Gln Met
65                  70                  75                  80  
Gln Glu Gln Thr Leu Gln Leu Glu Gln Gln Ser Lys Leu Lys Glu Tyr
                85                  90                  95      
Glu Ala Ala Val Glu Gln Leu Lys Ser Glu Gln Ile Arg Ala Gln Ala
            100                 105                 110         
Glu Glu Arg Arg Lys Thr Leu Ser Glu Glu Thr Arg Gln His Gln Ala
        115                 120                 125             
Arg Ala Gln Tyr Gln Asp Lys Leu Ala Arg Gln Arg Tyr Glu Asp Gln
    130                 135                 140                 
Leu Lys Gln Gln Gln Leu Leu Asn Glu Glu Asn Leu Arg Lys Gln Glu
145                 150                 155                 160 
Glu Ser Val Gln Lys Gln Glu Ala Met Arg Arg Ala Thr Val Glu Arg
                165                 170                 175     
Glu Met Glu Leu Arg His Lys Asn Glu Met Leu Arg Val Glu Ala Glu
            180                 185                 190         
Ala Arg Ala Arg Ala Lys Ala Glu Arg Glu Asn Ala Asp Ile Ile Arg
        195                 200                 205             
Glu Gln Ile Arg Leu Lys Ala Ala Glu His Arg Gln Thr Val Leu Glu
    210                 215                 220                 
Ser Ile Arg Thr Ala Gly Thr Leu Phe Gly Glu Gly Phe Arg Ala Phe
225                 230                 235                 240 
Val Thr Asp Trp Asp Lys Val Thr Ala Thr Val Ala Gly Leu Thr Leu
                245                 250                 255     
Leu Ala Val Gly Val Tyr Ser Ala Lys Asn Ala Thr Leu Val Ala Gly
            260                 265                 270         
Arg Phe Ile Glu Ala Arg Leu Gly Lys Pro Ser Leu Val Arg Glu Thr
        275                 280                 285             
Ser Arg Ile Thr Val Leu Glu Ala Leu Arg His Pro Ile Gln Val Ser
    290                 295                 300                 
Arg Arg Leu Leu Ser Arg Pro Gln Asp Ala Leu Glu Gly Val Val Leu
305                 310                 315                 320 
Ser Pro Ser Leu Glu Ala Arg Val Arg Asp Ile Ala Ile Ala Thr Arg
                325                 330                 335     
Asn Thr Lys Lys Asn Arg Ser Leu Tyr Arg Asn Ile Leu Met Tyr Gly
            340                 345                 350         
Pro Pro Gly Thr Gly Lys Thr Leu Phe Ala Lys Lys Leu Ala Leu His
        355                 360                 365             
Ser Gly Met Asp Tyr Ala Ile Met Thr Gly Gly Asp Val Ala Pro Met
    370                 375                 380                 
Gly Arg Glu Gly Val Thr Ala Met His Lys Leu Phe Asp Trp Ala Asn
385                 390                 395                 400 
Thr Ser Arg Arg Gly Leu Leu Leu Phe Val Asp Glu Ala Asp Ala Phe
                405                 410                 415     
Leu Arg Lys Arg Ala Thr Glu Lys Ile Ser Glu Asp Leu Arg Ala Thr
            420                 425                 430         
Leu Asn Ala Phe Leu Tyr Arg Thr Gly Gln His Ser Asn Lys Phe Met
        435                 440                 445             
Leu Val Leu Ala Ser Asn Gln Pro Glu Gln Phe Asp Trp Ala Ile Asn
    450                 455                 460                 
Asp Arg Ile Asn Glu Met Val His Phe Asp Leu Pro Gly Gln Glu Glu
465                 470                 475                 480 
Arg Glu Arg Leu Val Arg Met Tyr Phe Asp Lys Tyr Val Leu Lys Pro
                485                 490                 495     
Ala Thr Glu Gly Lys Gln Arg Leu Lys Leu Ala Gln Phe Asp Tyr Gly
            500                 505                 510         
Arg Lys Cys Ser Glu Val Ala Arg Leu Thr Glu Gly Met Ser Gly Arg
        515                 520                 525             
Glu Ile Ala Gln Leu Ala Val Ser Trp Gln Ala Thr Ala Tyr Ala Ser
    530                 535                 540                 
Glu Asp Gly Val Leu Thr Glu Ala Met Met Asp Thr Arg Val Gln Asp
545                 550                 555                 560 
Ala Val Gln Gln His Gln Gln Lys Met Cys Trp Leu Lys Ala Glu Gly
                565                 570                 575     
Pro Gly Arg Gly Asp Glu Pro Ser Pro Ser
            580                 585     


<210> 1807
<211> 468
<212> PRT
<213> Homo sapiens

<400> 1807
Met Gly Thr Val His Ala Arg Ser Leu Glu Pro Leu Pro Ser Ser Gly
 1               5                  10                  15      
Pro Asp Phe Gly Gly Leu Gly Glu Glu Ala Glu Phe Val Glu Val Glu
            20                  25                  30          
Pro Glu Ala Lys Gln Glu Ile Leu Glu Asn Lys Asp Val Val Val Gln
        35                  40                  45              
His Val His Phe Asp Gly Leu Gly Arg Thr Lys Asp Asp Ile Ile Ile
    50                  55                  60                  
Cys Glu Ile Gly Asp Val Phe Lys Ala Lys Asn Leu Ile Glu Val Met
65                  70                  75                  80  
Arg Lys Ser His Glu Ala Arg Glu Lys Leu Leu Arg Leu Gly Ile Phe
                85                  90                  95      
Arg Gln Val Asp Val Leu Ile Asp Thr Cys Gln Gly Asp Asp Ala Leu
            100                 105                 110         
Pro Asn Gly Leu Asp Val Thr Phe Glu Val Thr Glu Leu Arg Arg Leu
        115                 120                 125             
Thr Gly Ser Tyr Asn Thr Met Val Gly Asn Asn Glu Gly Ser Met Val
    130                 135                 140                 
Leu Gly Leu Lys Leu Pro Asn Leu Leu Gly Arg Ala Glu Lys Val Thr
145                 150                 155                 160 
Phe Gln Phe Ser Tyr Gly Thr Lys Glu Thr Ser Tyr Gly Leu Ser Phe
                165                 170                 175     
Phe Lys Pro Arg Pro Gly Asn Phe Glu Arg Asn Phe Ser Val Asn Leu
            180                 185                 190         
Tyr Lys Val Thr Gly Gln Phe Pro Trp Ser Ser Leu Arg Glu Thr Asp
        195                 200                 205             
Arg Gly Met Ser Ala Glu Tyr Ser Phe Pro Ile Trp Lys Thr Ser His
    210                 215                 220                 
Thr Val Lys Trp Glu Gly Val Trp Arg Glu Leu Gly Cys Leu Ser Arg
225                 230                 235                 240 
Thr Ala Ser Phe Ala Val Arg Lys Glu Ser Gly His Ser Leu Lys Ser
                245                 250                 255     
Ser Leu Ser His Ala Met Val Ile Asp Ser Arg Asn Ser Ser Ile Leu
            260                 265                 270         
Pro Arg Arg Gly Ala Leu Leu Lys Val Asn Gln Glu Leu Ala Gly Tyr
        275                 280                 285             
Thr Gly Gly Asp Val Ser Phe Ile Lys Glu Asp Phe Glu Leu Gln Leu
    290                 295                 300                 
Asn Lys Gln Leu Ile Phe Asp Ser Val Phe Ser Ala Ser Phe Trp Gly
305                 310                 315                 320 
Gly Met Leu Val Pro Ile Gly Asp Lys Pro Ser Ser Ile Ala Asp Arg
                325                 330                 335     
Phe Tyr Leu Gly Gly Pro Thr Ser Val Arg Gly Phe Ser Met His Ser
            340                 345                 350         
Ile Gly Pro Gln Ser Glu Gly Asp Tyr Leu Gly Gly Glu Ala Tyr Trp
        355                 360                 365             
Ala Gly Leu His Leu Tyr Thr Pro Leu Pro Phe Arg Pro Gly Gln Gly
    370                 375                 380                 
Gly Phe Gly Glu Leu Phe Arg Thr His Phe Phe Leu Asn Ala Gly Asn
385                 390                 395                 400 
Leu Cys Asn Leu Asn Tyr Gly Glu Gly Pro Lys Ala His Ile Arg Lys
                405                 410                 415     
Leu Ala Glu Cys Ile Arg Trp Ser Tyr Gly Ala Gly Ile Val Leu Arg
            420                 425                 430         
Leu Gly Asn Ile Ala Arg Leu Glu Leu Asn Tyr Cys Val Pro Met Gly
        435                 440                 445             
Val Gln Thr Gly Asp Arg Ile Cys Asp Gly Val Gln Phe Gly Ala Gly
    450                 455                 460                 
Ile Arg Phe Leu
465             


<210> 1808
<211> 568
<212> PRT
<213> Homo sapiens

<400> 1808
Val Asp Leu Ser Ser His Leu Ala Lys Val Thr Ala Glu Val Val Leu
 1               5                  10                  15      
Ala His Leu Gly Gly Gly Ser Thr Ser Arg Ala Thr Ser Phe Leu Leu
            20                  25                  30          
Ala Leu Glu Pro Glu Leu Glu Ala Arg Leu Ala His Leu Gly Val Gln
        35                  40                  45              
Val Lys Gly Glu Asp Glu Glu Glu Asn Asn Leu Glu Val Arg Glu Thr
    50                  55                  60                  
Lys Ile Lys Gly Lys Ser Gly Arg Phe Phe Thr Val Lys Leu Pro Val
65                  70                  75                  80  
Ala Leu Asp Pro Gly Ala Lys Ile Ser Val Ile Val Glu Thr Val Tyr
                85                  90                  95      
Thr His Val Leu His Pro Tyr Pro Thr Gln Ile Thr Gln Ser Glu Lys
            100                 105                 110         
Gln Phe Val Val Phe Glu Gly Asn His Tyr Phe Tyr Ser Pro Tyr Pro
        115                 120                 125             
Thr Lys Thr Gln Thr Met Arg Val Lys Leu Ala Ser Arg Asn Val Glu
    130                 135                 140                 
Ser Tyr Thr Lys Leu Gly Asn Pro Thr Arg Ser Glu Asp Leu Leu Asp
145                 150                 155                 160 
Tyr Gly Pro Phe Arg Asp Val Pro Ala Tyr Ser Gln Asp Thr Phe Lys
                165                 170                 175     
Val His Tyr Glu Asn Asn Ser Pro Phe Leu Thr Ile Thr Ser Met Thr
            180                 185                 190         
Arg Val Ile Glu Val Ser His Trp Gly Asn Ile Ala Val Glu Glu Asn
        195                 200                 205             
Val Asp Leu Lys His Thr Gly Ala Val Leu Lys Gly Pro Phe Ser Arg
    210                 215                 220                 
Tyr Asp Tyr Gln Arg Gln Pro Asp Ser Gly Ile Ser Ser Ile Arg Ser
225                 230                 235                 240 
Phe Lys Thr Ile Leu Pro Ala Ala Ala Gln Asp Val Tyr Tyr Arg Asp
                245                 250                 255     
Glu Ile Gly Asn Val Ser Thr Ser His Leu Leu Ile Leu Asp Asp Ser
            260                 265                 270         
Val Glu Met Glu Ile Arg Pro Arg Phe Pro Leu Phe Gly Gly Trp Lys
        275                 280                 285             
Thr His Tyr Ile Val Gly Tyr Asn Leu Pro Ser Tyr Glu Tyr Leu Tyr
    290                 295                 300                 
Asn Leu Gly Asp Gln Tyr Ala Leu Lys Met Arg Phe Val Asp His Val
305                 310                 315                 320 
Phe Asp Glu Gln Val Ile Asp Ser Leu Thr Val Lys Ile Ile Leu Pro
                325                 330                 335     
Glu Gly Ala Lys Asn Ile Glu Ile Asp Ser Pro Tyr Glu Ile Ser Arg
            340                 345                 350         
Ala Pro Asp Glu Leu His Tyr Thr Tyr Leu Asp Thr Phe Gly Arg Pro
        355                 360                 365             
Val Ile Val Ala Tyr Lys Lys Asn Leu Val Glu Gln His Ile Gln Asp
    370                 375                 380                 
Ile Val Val His Tyr Thr Phe Asn Lys Val Leu Met Leu Gln Glu Pro
385                 390                 395                 400 
Leu Leu Val Val Ala Ala Phe Tyr Ile Leu Phe Phe Thr Val Ile Ile
                405                 410                 415     
Tyr Val Arg Leu Asp Phe Ser Ile Thr Lys Asp Pro Ala Ala Glu Ala
            420                 425                 430         
Arg Met Lys Val Ala Cys Ile Thr Glu Gln Val Leu Thr Leu Val Asn
        435                 440                 445             
Lys Arg Ile Gly Leu Tyr Arg His Phe Asp Glu Thr Val Asn Arg Tyr
    450                 455                 460                 
Lys Gln Ser Arg Asp Ile Ser Thr Leu Asn Ser Gly Lys Lys Ser Leu
465                 470                 475                 480 
Glu Thr Glu His Lys Ala Leu Thr Ser Glu Ile Ala Leu Leu Gln Ser
                485                 490                 495     
Arg Leu Lys Thr Glu Gly Ser Asp Leu Cys Asp Arg Val Ser Glu Met
            500                 505                 510         
Gln Lys Leu Asp Ala Gln Val Lys Glu Leu Val Leu Lys Ser Ala Val
        515                 520                 525             
Glu Ala Glu Arg Leu Val Ala Gly Lys Leu Lys Lys Asp Thr Tyr Ile
    530                 535                 540                 
Glu Asn Glu Lys Leu Ile Ser Gly Lys Arg Gln Glu Leu Val Thr Lys
545                 550                 555                 560 
Ile Asp His Ile Leu Asp Ala Leu
                565             


<210> 1809
<211> 553
<212> PRT
<213> Homo sapiens

<400> 1809
Ser Leu Gln Glu Gln Val Ala Met Gln Arg Gln Val Leu Lys Glu Met
 1               5                  10                  15      
Glu Gln Gln Leu Gln Ser Ser His Gln Leu Thr Ala Arg Leu Arg Ala
            20                  25                  30          
Gln Ile Ala Met Tyr Glu Ser Glu Leu Glu Arg Ala His Gly Gln Met
        35                  40                  45              
Leu Glu Glu Met Gln Ser Leu Glu Glu Asp Lys Asn Arg Ala Ile Glu
    50                  55                  60                  
Glu Ala Phe Ala Arg Ala Gln Val Glu Met Lys Ala Val His Glu Asn
65                  70                  75                  80  
Leu Ala Gly Val Arg Thr Asn Leu Leu Thr Leu Gln Pro Ala Leu Arg
                85                  90                  95      
Thr Leu Thr Asn Asp Tyr Asn Gly Leu Lys Arg Gln Val Arg Gly Phe
            100                 105                 110         
Pro Leu Leu Leu Gln Glu Ala Leu Arg Ser Val Lys Ala Glu Ile Gly
        115                 120                 125             
Gln Ala Ile Glu Glu Val Asn Ser Asn Asn Gln Glu Leu Leu Arg Lys
    130                 135                 140                 
Tyr Arg Arg Glu Leu Gln Leu Arg Lys Lys Cys His Asn Glu Leu Val
145                 150                 155                 160 
Arg Leu Lys Gly Asn Ile Arg Val Ile Ala Arg Val Arg Pro Val Thr
                165                 170                 175     
Lys Glu Asp Gly Glu Gly Pro Glu Ala Thr Asn Ala Val Thr Phe Asp
            180                 185                 190         
Ala Asp Asp Asp Ser Ile Ile His Leu Leu His Lys Gly Lys Pro Val
        195                 200                 205             
Ser Phe Glu Leu Asp Lys Val Phe Ser Pro Gln Ala Ser Gln Gln Asp
    210                 215                 220                 
Val Phe Gln Glu Val Gln Ala Leu Val Thr Ser Cys Ile Asp Gly Phe
225                 230                 235                 240 
Asn Val Cys Ile Phe Ala Tyr Gly Gln Thr Gly Ala Gly Lys Thr Tyr
                245                 250                 255     
Thr Met Glu Gly Thr Ala Glu Asn Pro Gly Ile Asn Gln Arg Ala Leu
            260                 265                 270         
Gln Leu Leu Phe Ser Glu Val Gln Glu Lys Ala Ser Asp Trp Glu Tyr
        275                 280                 285             
Thr Ile Thr Val Ser Ala Ala Glu Ile Tyr Asn Glu Val Leu Arg Asp
    290                 295                 300                 
Leu Leu Gly Lys Glu Pro Gln Glu Lys Leu Glu Ile Arg Leu Cys Pro
305                 310                 315                 320 
Asp Gly Ser Gly Gln Leu Tyr Val Pro Gly Leu Thr Glu Phe Gln Val
                325                 330                 335     
Gln Ser Val Asp Asp Ile Asn Lys Val Phe Glu Phe Gly His Thr Asn
            340                 345                 350         
Arg Thr Thr Glu Phe Thr Asn Leu Asn Glu His Ser Ser Arg Ser His
        355                 360                 365             
Ala Leu Leu Ile Val Thr Val Arg Gly Val Asp Cys Ser Thr Gly Leu
    370                 375                 380                 
Arg Thr Thr Gly Lys Leu Asn Leu Val Asp Leu Ala Gly Ser Glu Arg
385                 390                 395                 400 
Val Gly Lys Ser Gly Ala Glu Gly Ser Arg Leu Arg Glu Ala Gln His
                405                 410                 415     
Ile Asn Lys Ser Leu Ser Ala Leu Gly Asp Val Ile Ala Ala Leu Arg
            420                 425                 430         
Ser Arg Gln Gly His Val Pro Phe Arg Asn Ser Lys Leu Thr Tyr Leu
        435                 440                 445             
Leu Gln Asp Ser Leu Ser Gly Asp Ser Lys Thr Leu Met Val Val Gln
    450                 455                 460                 
Val Ser Pro Val Glu Lys Asn Thr Ser Glu Thr Leu Tyr Ser Leu Lys
465                 470                 475                 480 
Phe Ala Glu Arg Val Arg Ser Val Glu Leu Gly Pro Gly Leu Arg Arg
                485                 490                 495     
Ala Glu Leu Gly Ser Trp Ser Ser Gln Glu His Leu Glu Trp Glu Pro
            500                 505                 510         
Ala Cys Gln Thr Pro Gln Pro Ser Ala Arg Ala His Ser Ala Pro Ser
        515                 520                 525             
Ser Gly Thr Ser Ser Arg Pro Gly Ser Ile Arg Arg Lys Leu Gln Pro
    530                 535                 540                 
Ser Gly Lys Ser Arg Pro Leu Pro Val
545                 550             


<210> 1810
<211> 1449
<212> PRT
<213> Homo sapiens

<400> 1810
Gly Arg Ser Arg Ser Arg Thr Ser Gly Arg Val Gly Leu Ala Ala Arg
 1               5                  10                  15      
Gly Gly Gly Gly Ala Ala Thr Ala Val Ala Ala Ala Ala Lys Met Ala
            20                  25                  30          
Glu Gly Leu Glu Arg Val Arg Ile Ser Ala Ser Glu Leu Arg Gly Ile
        35                  40                  45              
Leu Ala Thr Leu Ala Pro Gln Ala Gly Ser Arg Glu Asn Met Lys Glu
    50                  55                  60                  
Leu Lys Glu Ala Arg Pro Arg Lys Asp Asn Arg Arg Pro Asp Leu Glu
65                  70                  75                  80  
Ile Tyr Lys Pro Gly Leu Ser Arg Leu Arg Asn Lys Pro Lys Ile Lys
                85                  90                  95      
Glu Pro Pro Gly Ser Glu Glu Phe Lys Asp Glu Ile Val Asn Asp Arg
            100                 105                 110         
Asp Cys Ser Ala Val Glu Asn Gly Thr Gln Pro Val Lys Asp Val Cys
        115                 120                 125             
Lys Glu Leu Asn Asn Gln Glu Gln Asn Gly Pro Ile Asp Pro Glu Asn
    130                 135                 140                 
Asn Arg Gly Gln Glu Ser Phe Pro Arg Thr Ala Gly Gln Glu Asp Arg
145                 150                 155                 160 
Ser Leu Lys Ile Ile Lys Arg Thr Lys Lys Pro Asp Leu Gln Ile Tyr
                165                 170                 175     
Gln Pro Gly Arg Arg Leu Gln Thr Val Ser Lys Glu Ser Ala Ser Arg
            180                 185                 190         
Val Glu Glu Glu Glu Val Leu Asn Gln Val Glu Gln Leu Arg Val Glu
        195                 200                 205             
Glu Asp Glu Cys Arg Gly Asn Val Ala Lys Glu Glu Val Ala Asn Lys
    210                 215                 220                 
Pro Asp Arg Ala Glu Ile Glu Lys Ser Pro Gly Gly Gly Arg Val Gly
225                 230                 235                 240 
Ala Ala Lys Gly Glu Lys Gly Lys Arg Met Gly Lys Gly Glu Gly Val
                245                 250                 255     
Arg Glu Thr His Asp Asp Pro Ala Arg Gly Arg Pro Gly Ser Ala Lys
            260                 265                 270         
Arg Tyr Ser Arg Ser Asp Lys Arg Arg Asn Arg Tyr Arg Thr Arg Ser
        275                 280                 285             
Thr Ser Ser Ala Gly Ser Asn Asn Ser Ala Glu Gly Ala Gly Leu Thr
    290                 295                 300                 
Asp Asn Gly Cys Arg Arg Arg Arg Gln Asp Arg Thr Lys Glu Arg Pro
305                 310                 315                 320 
Pro Leu Lys Lys Gln Val Ser Val Ser Ser Thr Asp Ser Leu Asp Glu
                325                 330                 335     
Asp Arg Ile Asp Glu Pro Asp Gly Leu Gly Pro Arg Arg Ser Ser Glu
            340                 345                 350         
Arg Lys Arg His Leu Glu Arg Asn Trp Ser Gly Arg Gly Glu Gly Glu
        355                 360                 365             
Gln Lys Thr Ser Ala Lys Glu Tyr Arg Gly Thr Leu Arg Val Thr Phe
    370                 375                 380                 
Asp Ala Glu Ala Met Asn Lys Glu Ser Pro Met Val Arg Ser Ala Arg
385                 390                 395                 400 
Asp Asp Met Asp Arg Gly Lys Pro Asp Lys Gly Leu Ser Ser Gly Gly
                405                 410                 415     
Lys Gly Ser Glu Lys Gln Glu Ser Lys Asn Pro Lys Gln Glu Leu Arg
            420                 425                 430         
Gly Arg Gly Arg Gly Ile Leu Ile Leu Pro Ala His Thr Thr Leu Ser
        435                 440                 445             
Val Asn Ser Ala Gly Ser Pro Glu Ser Ala Pro Leu Gly Pro Arg Leu
    450                 455                 460                 
Leu Phe Gly Ser Gly Ser Lys Gly Ser Arg Ser Trp Gly Arg Gly Gly
465                 470                 475                 480 
Thr Thr Arg Arg Leu Trp Asp Pro Asn Asn Pro Asp Gln Lys Pro Ala
                485                 490                 495     
Leu Lys Thr Gln Thr Pro Gln Leu His Phe Leu Asp Thr Asp Asp Glu
            500                 505                 510         
Val Ser Pro Thr Ser Trp Gly Asp Ser Arg Gln Ala Gln Ala Ser Tyr
        515                 520                 525             
Tyr Lys Phe Gln Asn Ser Asp Asn Pro Tyr Tyr Tyr Pro Arg Thr Pro
    530                 535                 540                 
Gly Pro Ala Ser Gln Tyr Pro Tyr Thr Gly Tyr Asn Pro Leu Gln Tyr
545                 550                 555                 560 
Pro Val Gly Pro Thr Asn Gly Val Tyr Pro Gly Pro Tyr Tyr Pro Gly
                565                 570                 575     
Tyr Pro Thr Pro Ser Gly Gln Tyr Val Cys Ser Pro Leu Pro Thr Ser
            580                 585                 590         
Thr Met Ser Pro Glu Glu Val Glu Gln His Met Arg Asn Leu Gln Gln
        595                 600                 605             
Gln Glu Leu His Arg Leu Leu Arg Val Ala Asp Asn Gln Glu Leu Gln
    610                 615                 620                 
Leu Ser Asn Leu Leu Ser Arg Asp Arg Ile Ser Pro Glu Gly Leu Glu
625                 630                 635                 640 
Lys Met Ala Gln Leu Arg Ala Glu Leu Leu Gln Leu Tyr Glu Arg Cys
                645                 650                 655     
Ile Leu Leu Asp Ile Glu Phe Ser Asp Asn Gln Asn Val Asp Gln Ile
            660                 665                 670         
Leu Trp Lys Asn Ala Phe Tyr Gln Val Ile Glu Lys Phe Arg Gln Leu
        675                 680                 685             
Val Lys Asp Pro Asn Val Glu Asn Pro Glu Gln Ile Arg Asn Arg Leu
    690                 695                 700                 
Leu Glu Leu Leu Asp Glu Gly Ser Asp Phe Phe Asp Ser Leu Leu Gln
705                 710                 715                 720 
Lys Leu Gln Val Thr Tyr Lys Phe Lys Leu Glu Asp Tyr Met Asp Gly
                725                 730                 735     
Leu Ala Ile Arg Ser Lys Pro Leu Arg Lys Thr Val Lys Tyr Ala Leu
            740                 745                 750         
Ile Ser Ala Gln Arg Cys Met Ile Cys Gln Gly Asp Ile Ala Arg Tyr
        755                 760                 765             
Arg Glu Gln Ala Ser Asp Thr Ala Asn Tyr Gly Lys Ala Arg Ser Trp
    770                 775                 780                 
Tyr Leu Lys Ala Gln His Ile Ala Pro Lys Asn Gly Arg Pro Tyr Asn
785                 790                 795                 800 
Gln Leu Ala Leu Leu Ala Val Tyr Thr Arg Arg Lys Leu Asp Ala Val
                805                 810                 815     
Tyr Tyr Tyr Met Arg Ser Leu Ala Ala Ser Asn Pro Ile Leu Thr Ala
            820                 825                 830         
Lys Glu Ser Leu Met Ser Leu Phe Glu Glu Thr Lys Arg Lys Ala Glu
        835                 840                 845             
Gln Met Glu Lys Lys Gln His Glu Glu Phe Asp Leu Ser Pro Asp Gln
    850                 855                 860                 
Trp Arg Lys Gly Lys Lys Ser Thr Phe Arg His Val Gly Asp Asp Thr
865                 870                 875                 880 
Thr Arg Leu Glu Ile Trp Ile His Pro Ser His Pro Arg Ser Ser Gln
                885                 890                 895     
Gly Thr Glu Ser Gly Lys Asp Ser Glu Gln Glu Asn Gly Leu Gly Ser
            900                 905                 910         
Leu Ser Pro Ser Asp Leu Asn Lys Arg Phe Ile Leu Ser Phe Leu His
        915                 920                 925             
Ala His Gly Lys Leu Phe Thr Arg Ile Gly Met Glu Thr Phe Pro Ala
    930                 935                 940                 
Val Ala Glu Lys Val Leu Lys Glu Phe Gln Val Leu Leu Gln His Ser
945                 950                 955                 960 
Pro Ser Pro Ile Gly Ser Thr Arg Met Leu Gln Leu Met Thr Ile Asn
                965                 970                 975     
Met Phe Ala Val His Asn Ser Gln Leu Lys Asp Cys Phe Ser Glu Glu
            980                 985                 990         
Cys Arg Ser Val Ile Gln Glu Gln Ala Ala Ala Leu Gly Leu Ala Met
        995                 1000                1005            
Phe Ser Leu Leu Val Arg Arg Cys Thr Cys Leu Leu Lys Glu Ser Ala
    1010                1015                1020                
Lys Ala Gln Leu Ser Ser Pro Glu Asp Gln Asp Asp Gln Asp Asp Ile
1025                1030                1035                1040
Lys Val Ser Ser Phe Val Pro Asp Leu Lys Glu Leu Leu Pro Ser Val
                1045                1050                1055    
Lys Val Trp Ser Asp Trp Met Leu Gly Tyr Pro Asp Thr Trp Asn Pro
            1060                1065                1070        
Pro Pro Thr Ser Leu Asp Leu Pro Ser His Val Ala Val Asp Val Trp
        1075                1080                1085            
Ser Thr Leu Ala Asp Phe Cys Asn Ile Leu Thr Ala Val Asn Gln Ser
    1090                1095                1100                
Glu Val Pro Leu Tyr Lys Asp Pro Asp Asp Asp Leu Thr Leu Leu Ile
1105                1110                1115                1120
Leu Glu Glu Asp Arg Leu Leu Ser Gly Phe Val Pro Leu Leu Ala Ala
                1125                1130                1135    
Pro Gln Asp Pro Cys Tyr Val Glu Lys Thr Ser Asp Lys Val Ile Ala
            1140                1145                1150        
Ala Asp Cys Lys Arg Val Thr Val Leu Lys Tyr Phe Leu Glu Ala Leu
        1155                1160                1165            
Cys Gly Gln Glu Glu Pro Leu Leu Ala Phe Lys Gly Gly Lys Tyr Val
    1170                1175                1180                
Ser Val Ala Pro Val Pro Asp Thr Met Gly Lys Glu Met Gly Ser Gln
1185                1190                1195                1200
Glu Gly Thr Arg Leu Glu Asp Glu Glu Glu Asp Val Val Ile Glu Asp
                1205                1210                1215    
Phe Glu Glu Asp Ser Glu Ala Glu Gly Ser Gly Gly Glu Asp Asp Ile
            1220                1225                1230        
Arg Glu Leu Arg Ala Lys Lys Leu Ala Leu Ala Arg Lys Ile Ala Glu
        1235                1240                1245            
Gln Gln Arg Arg Gln Glu Lys Ile Gln Ala Val Leu Glu Asp His Ser
    1250                1255                1260                
Gln Met Arg Gln Met Glu Leu Glu Ile Arg Pro Leu Phe Leu Val Pro
1265                1270                1275                1280
Asp Thr Asn Gly Phe Ile Asp His Leu Ala Ser Leu Ala Arg Leu Leu
                1285                1290                1295    
Glu Ser Arg Lys Tyr Ile Leu Val Val Pro Leu Ile Val Ile Asn Glu
            1300                1305                1310        
Leu Asp Gly Leu Ala Lys Gly Gln Glu Thr Asp His Arg Ala Gly Gly
        1315                1320                1325            
Tyr Ala Arg Val Val Gln Glu Lys Ala Arg Lys Ser Ile Glu Phe Leu
    1330                1335                1340                
Glu Gln Arg Phe Glu Ser Arg Asp Ser Cys Leu Arg Ala Leu Thr Ser
1345                1350                1355                1360
Arg Gly Asn Glu Leu Glu Ser Ile Ala Phe Arg Ser Glu Asp Ile Thr
                1365                1370                1375    
Gly Gln Leu Gly Asn Asn Asp Asp Leu Ile Leu Ser Cys Cys Leu His
            1380                1385                1390        
Tyr Cys Lys Asp Lys Ala Lys Asp Phe Met Pro Ala Ser Lys Glu Glu
        1395                1400                1405            
Pro Ile Arg Leu Leu Arg Glu Val Val Leu Leu Thr Asp Asp Arg Asn
    1410                1415                1420                
Leu Arg Val Lys Ala Leu Thr Arg Asn Val Pro Val Arg Asp Ile Pro
1425                1430                1435                1440
Ala Phe Leu Thr Trp Ala Gln Val Gly
                1445                


<210> 1811
<211> 896
<212> PRT
<213> Homo sapiens

<400> 1811
Phe Ala Val Val Lys Leu Gly Arg His Arg Ile Thr Lys Thr Glu Val
 1               5                  10                  15      
Ala Ile Lys Ile Ile Asp Lys Ser Gln Leu Asp Ala Val Asn Leu Glu
            20                  25                  30          
Lys Ile Tyr Arg Glu Val Gln Ile Met Lys Met Leu Asp His Pro His
        35                  40                  45              
Ile Ile Lys Leu Tyr Gln Val Met Glu Thr Lys Ser Met Leu Tyr Leu
    50                  55                  60                  
Val Thr Glu Tyr Ala Lys Asn Gly Glu Ile Phe Asp Tyr Leu Ala Asn
65                  70                  75                  80  
His Gly Arg Leu Asn Glu Ser Glu Ala Arg Arg Lys Phe Trp Gln Ile
                85                  90                  95      
Leu Ser Ala Val Asp Tyr Cys His Gly Arg Lys Ile Val His Arg Asp
            100                 105                 110         
Leu Lys Ala Glu Asn Leu Leu Leu Asp Asn Asn Met Asn Ile Lys Ile
        115                 120                 125             
Ala Asp Phe Gly Phe Gly Asn Phe Phe Lys Ser Gly Glu Leu Leu Ala
    130                 135                 140                 
Thr Trp Cys Gly Ser Pro Pro Tyr Ala Ala Pro Glu Val Phe Glu Gly
145                 150                 155                 160 
Gln Gln Tyr Glu Gly Pro Gln Leu Asp Ile Trp Ser Met Gly Val Val
                165                 170                 175     
Leu Tyr Val Leu Val Cys Gly Ala Leu Pro Phe Asp Gly Pro Thr Leu
            180                 185                 190         
Pro Ile Leu Arg Gln Arg Val Leu Glu Gly Arg Phe Arg Ile Pro Tyr
        195                 200                 205             
Phe Met Ser Glu Asp Cys Glu His Leu Ile Arg Arg Met Leu Val Leu
    210                 215                 220                 
Asp Pro Ser Lys Arg Leu Thr Ile Ala Gln Ile Lys Glu His Lys Trp
225                 230                 235                 240 
Met Leu Ile Glu Val Pro Val Gln Arg Pro Val Leu Tyr Pro Gln Glu
                245                 250                 255     
Gln Glu Asn Glu Pro Ser Ile Gly Glu Phe Asn Glu Gln Val Leu Arg
            260                 265                 270         
Leu Met His Ser Leu Gly Ile Asp Gln Gln Lys Thr Ile Glu Ser Leu
        275                 280                 285             
Gln Asn Lys Ser Tyr Asn His Phe Ala Ala Ile Tyr Phe Leu Leu Val
    290                 295                 300                 
Glu Arg Leu Lys Ser His Arg Ser Ser Phe Pro Val Glu Gln Arg Leu
305                 310                 315                 320 
Asp Gly Arg Gln Arg Arg Pro Ser Thr Ile Ala Glu Gln Thr Val Ala
                325                 330                 335     
Lys Ala Gln Thr Val Gly Leu Pro Val Thr Met His Ser Pro Asn Met
            340                 345                 350         
Arg Leu Leu Arg Ser Ala Leu Leu Pro Gln Ala Ser Asn Val Glu Ala
        355                 360                 365             
Phe Ser Phe Pro Ala Ser Gly Cys Gln Ala Glu Ala Ala Phe Met Glu
    370                 375                 380                 
Glu Glu Cys Val Asp Thr Pro Lys Val Asn Gly Cys Leu Leu Asp Pro
385                 390                 395                 400 
Val Pro Pro Val Leu Val Arg Lys Gly Cys Gln Ser Leu Pro Ser Asn
                405                 410                 415     
Met Met Glu Thr Ser Ile Asp Glu Gly Leu Glu Thr Glu Gly Glu Ala
            420                 425                 430         
Glu Glu Asp Pro Ala His Ala Phe Glu Ala Phe Gln Ser Thr Arg Ser
        435                 440                 445             
Gly Gln Arg Arg His Thr Leu Ser Glu Val Thr Asn Gln Leu Val Val
    450                 455                 460                 
Met Pro Gly Ala Gly Lys Ile Phe Ser Met Asn Asp Ser Pro Ser Leu
465                 470                 475                 480 
Asp Ser Val Asp Ser Glu Tyr Asp Met Gly Ser Val Gln Arg Asp Leu
                485                 490                 495     
Asn Phe Leu Glu Asp Asn Pro Ser Leu Lys Asp Ile Met Leu Ala Asn
            500                 505                 510         
Gln Pro Ser Pro Arg Met Thr Ser Pro Phe Ile Ser Leu Arg Pro Thr
        515                 520                 525             
Asn Pro Ala Met Gln Ala Leu Ser Ser Gln Lys Arg Glu Val His Asn
    530                 535                 540                 
Arg Ser Pro Val Ser Phe Arg Glu Gly Arg Arg Ala Ser Asp Thr Ser
545                 550                 555                 560 
Leu Thr Gln Gly Ile Val Ala Phe Arg Gln His Leu Gln Asn Leu Ala
                565                 570                 575     
Arg Thr Lys Gly Ile Leu Glu Leu Asn Lys Val Gln Leu Leu Tyr Glu
            580                 585                 590         
Gln Ile Gly Pro Glu Ala Asp Pro Asn Leu Ala Pro Ala Ala Pro Gln
        595                 600                 605             
Leu Gln Asp Leu Ala Ser Ser Cys Pro Gln Glu Glu Val Ser Gln Gln
    610                 615                 620                 
Gln Glu Ser Val Ser Thr Leu Pro Ala Ser Val His Pro Gln Leu Ser
625                 630                 635                 640 
Pro Arg Gln Ser Leu Glu Thr Gln Tyr Leu Gln His Arg Leu Gln Lys
                645                 650                 655     
Pro Ser Leu Leu Ser Lys Ala Gln Asn Thr Cys Gln Leu Tyr Cys Lys
            660                 665                 670         
Glu Pro Pro Arg Ser Leu Glu Gln Gln Leu Gln Glu His Arg Leu Gln
        675                 680                 685             
Gln Lys Arg Leu Phe Leu Gln Lys Gln Ser Gln Leu Gln Ala Tyr Phe
    690                 695                 700                 
Asn Gln Met Gln Ile Ala Glu Ser Ser Tyr Pro Gln Pro Ser Gln Gln
705                 710                 715                 720 
Leu Pro Leu Pro Arg Gln Glu Thr Pro Pro Pro Ser Gln Gln Ala Pro
                725                 730                 735     
Pro Phe Ser Leu Thr Gln Pro Leu Ser Pro Val Leu Glu Pro Ser Ser
            740                 745                 750         
Glu Gln Met Gln Tyr Ser Pro Phe Leu Ser Gln Tyr Gln Glu Met Gln
        755                 760                 765             
Leu Gln Pro Leu Pro Ser Thr Ser Gly Pro Arg Ala Ala Pro Pro Leu
    770                 775                 780                 
Pro Thr Gln Leu Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro
785                 790                 795                 800 
Pro Pro Arg Gln Pro Gly Ala Ala Pro Ala Pro Leu Gln Phe Ser Tyr
                805                 810                 815     
Gln Thr Cys Glu Leu Pro Ser Ala Ala Ser Pro Ala Pro Asp Tyr Pro
            820                 825                 830         
Thr Pro Cys Gln Tyr Pro Val Asp Gly Ala Gln Gln Ser Asp Leu Thr
        835                 840                 845             
Gly Pro Asp Cys Pro Arg Ser Pro Gly Leu Gln Glu Ala Pro Ser Ser
    850                 855                 860                 
Tyr Asp Pro Leu Ala Leu Ser Glu Leu Pro Gly Leu Phe Asp Cys Glu
865                 870                 875                 880 
Met Leu Asp Ala Val Asp Pro Gln His Asn Gly Tyr Val Leu Val Asn
                885                 890                 895     


<210> 1812
<211> 620
<212> PRT
<213> Homo sapiens

<400> 1812
Thr Cys Pro Pro Leu Leu Ala Leu Val Ile Thr Phe Ser Gly Arg Val
 1               5                  10                  15      
Arg Leu Arg Thr Pro Lys Cys Ser Ile Pro Lys Glu Ser Leu Gly Asn
            20                  25                  30          
Gln Ala Pro Ser Ile Leu Ser Gln Ala Pro Gln Pro Ser Pro Arg Glu
        35                  40                  45              
Pro Val Arg Asn Asp Pro Thr Met Ala Lys Leu Trp Phe Lys Phe Gln
    50                  55                  60                  
Arg Tyr Phe Arg Arg Lys Pro Val Arg Phe Phe Thr Phe Leu Ala Leu
65                  70                  75                  80  
Tyr Leu Thr Ala Gly Ser Leu Val Phe Leu His Ser Gly Phe Val Gly
                85                  90                  95      
Gln Pro Ala Val Ser Gly Asn Gln Ala Asn Pro Ala Ala Ala Gly Gly
            100                 105                 110         
Pro Ala Glu Gly Ala Glu Leu Ser Phe Leu Gly Asp Met His Leu Gly
        115                 120                 125             
Arg Gly Phe Arg Asp Thr Gly Glu Ala Ser Ser Ile Ala Arg Arg Tyr
    130                 135                 140                 
Gly Pro Trp Phe Lys Gly Lys Asp Gly Asn Glu Arg Ala Lys Leu Gly
145                 150                 155                 160 
Asp Tyr Gly Gly Ala Trp Ser Arg Ala Leu Lys Gly Arg Val Val Arg
                165                 170                 175     
Glu Lys Glu Glu Glu Arg Ala Lys Tyr Ile Gly Cys Tyr Leu Asp Asp
            180                 185                 190         
Thr Gln Ser Arg Ala Leu Arg Gly Val Ser Phe Phe Asp Tyr Lys Lys
        195                 200                 205             
Met Thr Ile Phe Arg Cys Gln Asp Asn Cys Ala Glu Arg Gly Tyr Leu
    210                 215                 220                 
Tyr Gly Gly Leu Glu Phe Gly Ala Glu Cys Tyr Cys Gly His Lys Ile
225                 230                 235                 240 
Gln Ala Thr Asn Val Ser Glu Ala Glu Cys Asp Met Glu Cys Lys Gly
                245                 250                 255     
Glu Arg Gly Ser Val Cys Gly Gly Ala Asn Arg Leu Ser Val Tyr Arg
            260                 265                 270         
Leu Gln Leu Ala Gln Glu Ser Ala Arg Arg Tyr Gly Ser Ala Val Phe
        275                 280                 285             
Arg Gly Cys Phe Arg Arg Pro Asp Asn Leu Ser Leu Ala Leu Pro Val
    290                 295                 300                 
Thr Ala Ala Met Leu Asn Met Ser Val Asp Lys Cys Val Asp Phe Cys
305                 310                 315                 320 
Thr Glu Lys Glu Tyr Pro Leu Ala Ala Leu Ala Gly Thr Ala Cys His
                325                 330                 335     
Cys Gly Phe Pro Thr Thr Arg Phe Pro Leu His Asp Arg Glu Asp Glu
            340                 345                 350         
Gln Leu Cys Ala Gln Lys Cys Ser Ala Glu Glu Phe Glu Ser Cys Gly
        355                 360                 365             
Thr Pro Ser Tyr Phe Ile Val Tyr Gln Thr Gln Val Gln Asp Asn Arg
    370                 375                 380                 
Cys Met Asp Arg Arg Phe Leu Pro Gly Lys Ser Lys Gln Leu Ile Ala
385                 390                 395                 400 
Leu Ala Ser Phe Pro Gly Ala Gly Asn Thr Trp Ala Arg His Leu Ile
                405                 410                 415     
Glu Leu Ala Thr Gly Phe Tyr Thr Gly Ser Tyr Tyr Phe Asp Gly Ser
            420                 425                 430         
Leu Tyr Asn Lys Gly Phe Lys Gly Glu Arg Asp His Trp Arg Ser Gly
        435                 440                 445             
Arg Thr Ile Cys Ile Lys Thr His Glu Ser Gly Gln Lys Glu Ile Glu
    450                 455                 460                 
Ala Phe Asp Ala Ala Ile Leu Leu Ile Arg Asn Pro Tyr Lys Ala Leu
465                 470                 475                 480 
Met Ala Glu Phe Asn Arg Lys Tyr Gly Gly His Ile Gly Phe Ala Ala
                485                 490                 495     
His Ala His Trp Lys Gly Lys Glu Trp Pro Glu Phe Val Arg Asn Tyr
            500                 505                 510         
Ala Pro Trp Trp Ala Thr His Thr Leu Asp Trp Leu Lys Phe Gly Lys
        515                 520                 525             
Lys Val Leu Val Val His Phe Glu Asp Leu Lys Gln Asp Leu Phe Val
    530                 535                 540                 
Gln Leu Gly Arg Met Val Ser Leu Leu Gly Val Ala Val Arg Glu Asp
545                 550                 555                 560 
Arg Leu Leu Cys Val Glu Ser Gln Lys Asp Gly Asn Phe Lys Arg Ser
                565                 570                 575     
Gly Leu Arg Lys Leu Glu Tyr Asp Pro Tyr Thr Ala Asp Met Gln Lys
            580                 585                 590         
Thr Ile Ser Ala Tyr Ile Lys Met Val Asp Ala Ala Leu Lys Gly Arg
        595                 600                 605             
Asn Leu Thr Gly Val Pro Asp Asp Tyr Tyr Pro Arg
    610                 615                 620 


<210> 1813
<211> 1727
<212> PRT
<213> Homo sapiens

<400> 1813
Ala Leu Leu His Phe Met Arg Glu Lys Glu Gln Glu Arg Glu Glu Gln
 1               5                  10                  15      
Leu Met Glu Asp Lys Lys Arg Lys Lys Glu Asp Lys Lys Lys Lys Glu
            20                  25                  30          
Ala Thr Gln Lys Val Thr Glu Gln Lys Thr Lys Val Pro Glu Val Thr
        35                  40                  45              
Lys Pro Ser Leu Ser Gln Pro Thr Ala Ala Ser Pro Ile Gly Ser Ser
    50                  55                  60                  
Pro Ser Pro Pro Val Asn Gly Gly Asn Asn Ala Lys Arg Val Ala Val
65                  70                  75                  80  
Pro Asn Gly Gln Pro Pro Ser Ala Ala Arg Tyr Met Pro Arg Glu Val
                85                  90                  95      
Pro Pro Arg Phe Arg Cys Gln Gln Asp His Lys Val Leu Leu Lys Arg
            100                 105                 110         
Gly Gln Pro Pro Pro Pro Ser Cys Met Leu Leu Gly Gly Gly Ala Gly
        115                 120                 125             
Pro Pro Pro Cys Thr Ala Pro Gly Ala Asn Pro Asn Asn Ala Gln Val
    130                 135                 140                 
Thr Gly Ala Leu Leu Gln Ser Glu Ser Gly Thr Ala Pro Asp Ser Thr
145                 150                 155                 160 
Leu Gly Gly Ala Ala Ala Ser Asn Tyr Ala Asn Ser Thr Trp Gly Ser
                165                 170                 175     
Gly Ala Ser Ser Asn Asn Gly Thr Ser Pro Asn Pro Ile His Ile Trp
            180                 185                 190         
Asp Lys Val Ile Val Asp Gly Ser Asp Met Glu Glu Trp Pro Cys Ile
        195                 200                 205             
Ala Ser Lys Asp Thr Glu Ser Ser Ser Glu Asn Thr Thr Asp Asn Asn
    210                 215                 220                 
Ser Ala Ser Asn Pro Gly Ser Glu Lys Ser Thr Leu Pro Gly Ser Thr
225                 230                 235                 240 
Thr Ser Asn Lys Gly Lys Gly Ser Gln Cys Gln Ser Ala Ser Ser Gly
                245                 250                 255     
Asn Glu Cys Asn Leu Gly Val Trp Lys Ser Asp Pro Lys Ala Lys Ser
            260                 265                 270         
Val Gln Ser Ser Asn Ser Thr Thr Glu Asn Asn Asn Gly Leu Gly Asn
        275                 280                 285             
Trp Arg Asn Val Ser Gly Gln Asp Arg Ile Gly Pro Gly Ser Gly Phe
    290                 295                 300                 
Ser Asn Phe Asn Pro Asn Ser Asn Pro Ser Ala Trp Pro Ala Leu Val
305                 310                 315                 320 
Gln Glu Gly Thr Ser Arg Lys Gly Ala Leu Glu Thr Asp Asn Ser Asn
                325                 330                 335     
Ser Ser Ala Gln Val Ser Thr Val Gly Gln Thr Ser Arg Glu Gln Gln
            340                 345                 350         
Ser Lys Met Glu Asn Ala Gly Val Asn Phe Val Val Ser Gly Arg Glu
        355                 360                 365             
Gln Ala Gln Ile His Asn Thr Asp Gly Pro Lys Asn Gly Asn Thr Asn
    370                 375                 380                 
Ser Leu Asn Leu Ser Ser Pro Asn Pro Met Glu Asn Lys Gly Met Pro
385                 390                 395                 400 
Phe Gly Met Gly Leu Gly Asn Thr Ser Arg Ser Thr Asp Ala Pro Ser
                405                 410                 415     
Gln Ser Thr Gly Asp Arg Lys Thr Gly Ser Val Gly Ser Trp Gly Ala
            420                 425                 430         
Ala Arg Gly Pro Ser Gly Thr Asp Thr Val Ser Gly Gln Ser Asn Ser
        435                 440                 445             
Gly Asn Asn Gly Asn Asn Gly Lys Glu Arg Glu Asp Ser Trp Lys Gly
    450                 455                 460                 
Ala Ser Val Gln Lys Ser Thr Gly Ser Lys Asn Asp Ser Trp Asp Asn
465                 470                 475                 480 
Asn Asn Arg Ser Thr Gly Gly Ser Trp Asn Phe Gly Pro Gln Asp Ser
                485                 490                 495     
Asn Asp Asn Lys Trp Gly Glu Gly Asn Lys Met Thr Ser Gly Val Ser
            500                 505                 510         
Gln Gly Glu Trp Lys Gln Pro Thr Gly Ser Asp Glu Leu Lys Ile Gly
        515                 520                 525             
Glu Trp Ser Gly Pro Asn Gln Pro Asn Ser Ser Thr Gly Ala Trp Asp
    530                 535                 540                 
Asn Gln Lys Gly His Pro Leu Pro Glu Asn Gln Gly Asn Ala Gln Ala
545                 550                 555                 560 
Pro Cys Trp Gly Arg Ser Ser Ser Ser Thr Gly Ser Glu Val Gly Gly
                565                 570                 575     
Gln Ser Thr Gly Ser Asn His Lys Ala Gly Ser Ser Asp Ser His Asn
            580                 585                 590         
Ser Gly Arg Arg Ser Tyr Arg Pro Thr His Pro Asp Cys Gln Ala Val
        595                 600                 605             
Leu Gln Thr Leu Leu Ser Arg Thr Asp Leu Asp Pro Arg Val Leu Ser
    610                 615                 620                 
Asn Thr Gly Trp Gly Gln Thr Gln Ile Lys Gln Asp Thr Val Trp Asp
625                 630                 635                 640 
Ile Glu Glu Val Pro Arg Pro Glu Gly Lys Ser Asp Lys Gly Thr Glu
                645                 650                 655     
Gly Trp Glu Ser Ala Ala Thr Gln Thr Lys Asn Ser Gly Gly Trp Gly
            660                 665                 670         
Asp Ala Pro Ser Gln Ser Asn Gln Met Lys Ser Gly Trp Gly Glu Leu
        675                 680                 685             
Ser Ala Ser Thr Glu Trp Lys Asp Pro Lys Asn Thr Gly Gly Trp Asn
    690                 695                 700                 
Asp Tyr Lys Asn Asn Asn Ser Ser Asn Trp Gly Gly Gly Arg Pro Asp
705                 710                 715                 720 
Glu Lys Thr Pro Ser Ser Trp Asn Glu Asn Pro Ser Lys Asp Gln Gly
                725                 730                 735     
Trp Gly Gly Gly Arg Gln Pro Asn Gln Gly Trp Ser Ser Gly Lys Asn
            740                 745                 750         
Gly Trp Gly Glu Glu Val Asp Gln Thr Lys Asn Ser Asn Trp Glu Ser
        755                 760                 765             
Ser Ala Ser Lys Pro Val Ser Gly Trp Gly Glu Gly Gly Gln Asn Glu
    770                 775                 780                 
Ile Gly Thr Trp Gly Asn Gly Gly Asn Ala Ser Leu Ala Ser Lys Gly
785                 790                 795                 800 
Gly Trp Glu Asp Cys Lys Arg Ser Pro Ala Trp Asn Glu Thr Gly Arg
                805                 810                 815     
Gln Pro Asn Ser Trp Asn Lys Gln His Gln Gln Gln Gln Pro Pro Gln
            820                 825                 830         
Gln Pro Pro Pro Pro Gln Pro Glu Ala Ser Gly Ser Trp Gly Gly Pro
        835                 840                 845             
Pro Pro Pro Pro Pro Gly Asn Val Arg Pro Ser Asn Ser Ser Trp Ser
    850                 855                 860                 
Ser Gly Pro Gln Pro Ala Thr Pro Lys Asp Glu Glu Pro Ser Gly Trp
865                 870                 875                 880 
Glu Glu Pro Ser Pro Gln Ser Ile Ser Arg Lys Met Asp Ile Asp Asp
                885                 890                 895     
Gly Thr Ser Ala Trp Gly Asp Pro Asn Ser Tyr Asn Tyr Lys Asn Val
            900                 905                 910         
Asn Leu Trp Asp Lys Asn Ser Gln Gly Gly Pro Ala Pro Arg Glu Pro
        915                 920                 925             
Asn Leu Pro Thr Pro Met Thr Ser Lys Ser Ala Ser Asp Ser Lys Ser
    930                 935                 940                 
Met Gln Asp Gly Trp Gly Glu Ser Asp Gly Pro Val Thr Gly Ala Arg
945                 950                 955                 960 
His Pro Ser Trp Glu Glu Glu Glu Asp Gly Gly Val Trp Asn Thr Thr
                965                 970                 975     
Gly Ser Gln Gly Ser Ala Ser Ser His Asn Ser Ala Ser Trp Gly Gln
            980                 985                 990         
Gly Gly Lys Lys Gln Met Lys Cys Ser Leu Lys Gly Gly Asn Asn Asp
        995                 1000                1005            
Ser Trp Met Asn Pro Leu Ala Lys Gln Phe Ser Asn Met Gly Leu Leu
    1010                1015                1020                
Ser Gln Thr Glu Asp Asn Pro Ser Ser Lys Met Asp Leu Ser Val Gly
1025                1030                1035                1040
Ser Leu Ser Asp Lys Lys Phe Asp Val Asp Lys Arg Ala Met Asn Leu
                1045                1050                1055    
Gly Asp Phe Asn Asp Ile Met Arg Lys Asp Arg Ser Gly Phe Arg Pro
            1060                1065                1070        
Pro Asn Ser Lys Asp Met Gly Thr Thr Asp Ser Gly Pro Tyr Phe Glu
        1075                1080                1085            
Lys Gly Gly Ser His Gly Leu Phe Gly Asn Ser Thr Ala Gln Ser Arg
    1090                1095                1100                
Gly Leu His Thr Pro Val Gln Pro Leu Asn Ser Ser Pro Ser Leu Arg
1105                1110                1115                1120
Ala Gln Val Pro Pro Gln Phe Ile Ser Pro Gln Val Ser Ala Ser Met
                1125                1130                1135    
Leu Lys Gln Phe Pro Asn Ser Gly Leu Ser Pro Gly Leu Phe Asn Val
            1140                1145                1150        
Gly Pro Gln Leu Ser Pro Gln Gln Ile Ala Met Leu Ser Gln Leu Pro
        1155                1160                1165            
Gln Ile Pro Gln Phe Gln Leu Ala Cys Gln Leu Leu Leu Gln Gln Gln
    1170                1175                1180                
Gln Gln Gln Gln Leu Leu Gln Asn Gln Arg Lys Ile Ser Gln Ala Val
1185                1190                1195                1200
Arg Gln Gln Gln Glu Gln Gln Leu Ala Arg Met Val Ser Ala Leu Gln
                1205                1210                1215    
Gln Gln Gln Gln Gln Gln Arg Gln Pro Gly Met Lys His Ser Pro Ser
            1220                1225                1230        
His Pro Val Gly Pro Lys Pro His Leu Asp Asn Met Val Pro Asn Ala
        1235                1240                1245            
Leu Asn Val Gly Leu Pro Asp Leu Gln Thr Lys Gly Pro Ile Pro Gly
    1250                1255                1260                
Tyr Gly Ser Gly Phe Ser Ser Gly Gly Met Asp Tyr Gly Met Val Gly
1265                1270                1275                1280
Gly Lys Glu Ala Gly Thr Glu Ser Arg Phe Lys Gln Trp Thr Ser Met
                1285                1290                1295    
Met Glu Gly Leu Pro Ser Val Ala Thr Gln Glu Ala Asn Met His Lys
            1300                1305                1310        
Asn Gly Ala Ile Val Ala Pro Gly Lys Thr Arg Gly Gly Ser Pro Tyr
        1315                1320                1325            
Asn Gln Phe Asp Ile Ile Pro Gly Asp Thr Leu Gly Gly His Thr Gly
    1330                1335                1340                
Pro Ala Gly Asp Ser Trp Leu Pro Ala Lys Ser Pro Pro Thr Asn Lys
1345                1350                1355                1360
Ile Gly Ser Lys Ser Ser Asn Ala Ser Trp Pro Pro Glu Phe Gln Pro
                1365                1370                1375    
Gly Val Pro Trp Lys Gly Ile Gln Asn Ile Asp Pro Glu Ser Asp Pro
            1380                1385                1390        
Tyr Val Thr Pro Gly Ser Val Leu Gly Gly Thr Ala Thr Ser Pro Ile
        1395                1400                1405            
Val Asp Thr Asp His Gln Leu Leu Arg Asp Asn Thr Thr Gly Ser Asn
    1410                1415                1420                
Ser Ser Leu Asn Thr Ser Leu Pro Ser Pro Gly Ala Trp Pro Tyr Ser
1425                1430                1435                1440
Ala Ser Asp Asn Ser Phe Thr Asn Val His Ser Thr Ser Ala Lys Phe
                1445                1450                1455    
Pro Asp Tyr Lys Ser Thr Trp Ser Pro Asp Pro Ile Gly His Asn Pro
            1460                1465                1470        
Thr His Leu Ser Asn Lys Met Trp Lys Asn His Ile Ser Ser Arg Asn
        1475                1480                1485            
Thr Thr Pro Leu Pro Arg Pro Pro Pro Gly Leu Thr Asn Pro Lys Pro
    1490                1495                1500                
Ser Ser Pro Trp Ser Ser Thr Ala Pro Arg Ser Val Arg Gly Trp Gly
1505                1510                1515                1520
Thr Gln Asp Ser Arg Leu Ala Ser Ala Ser Thr Trp Ser Asp Gly Gly
                1525                1530                1535    
Ser Val Arg Pro Ser Tyr Trp Leu Val Leu His Asn Leu Thr Pro Gln
            1540                1545                1550        
Ile Asp Gly Ser Thr Leu Arg Thr Ile Cys Met Gln His Gly Pro Leu
        1555                1560                1565            
Leu Thr Phe His Leu Asn Leu Thr Gln Gly Thr Ala Leu Ile Arg Tyr
    1570                1575                1580                
Ser Thr Lys Gln Glu Ala Ala Lys Ala Gln Thr Ala Leu His Met Cys
1585                1590                1595                1600
Val Leu Gly Asn Thr Thr Ile Leu Ala Glu Phe Ala Thr Asp Asp Glu
                1605                1610                1615    
Val Ser Arg Phe Leu Ala Gln Ala Gln Pro Pro Thr Pro Ala Ala Thr
            1620                1625                1630        
Pro Ser Ala Pro Ala Ala Gly Trp Gln Ser Leu Glu Thr Gly Gln Asn
        1635                1640                1645            
Gln Ser Asp Pro Val Gly Pro Ala Leu Asn Leu Phe Gly Gly Ser Thr
    1650                1655                1660                
Gly Leu Gly Gln Trp Ser Ser Ser Ala Gly Gly Ser Ser Gly Ala Asp
1665                1670                1675                1680
Leu Ala Gly Ala Ser Leu Trp Gly Pro Pro Asn Tyr Ser Ser Ser Leu
                1685                1690                1695    
Trp Gly Val Pro Thr Val Glu Asp Pro His Arg Met Gly Ser Pro Ala
            1700                1705                1710        
Pro Leu Leu Pro Gly Asp Leu Leu Gly Gly Gly Ser Asp Ser Ile
        1715                1720                1725        


<210> 1814
<211> 346
<212> PRT
<213> Homo sapiens

<400> 1814
Met Asp Trp Val Met Lys His Asn Gly Pro Asn Asp Ala Ser Asp Gly
 1               5                  10                  15      
Thr Val Arg Leu Arg Gly Leu Pro Phe Gly Cys Ser Lys Glu Glu Ile
            20                  25                  30          
Val Gln Phe Phe Gln Gly Leu Glu Ile Val Pro Asn Gly Ile Thr Leu
        35                  40                  45              
Thr Met Asp Tyr Gln Gly Arg Ser Thr Gly Glu Ala Phe Val Gln Phe
    50                  55                  60                  
Ala Ser Lys Glu Ile Ala Glu Asn Ala Leu Gly Lys His Lys Glu Arg
65                  70                  75                  80  
Ile Gly His Arg Tyr Ile Glu Ile Phe Arg Ser Ser Arg Ser Glu Ile
                85                  90                  95      
Lys Gly Phe Tyr Asp Pro Pro Arg Arg Leu Leu Gly Gln Arg Pro Gly
            100                 105                 110         
Pro Tyr Asp Arg Pro Ile Gly Gly Arg Gly Gly Tyr Tyr Gly Ala Gly
        115                 120                 125             
Arg Gly Ser Met Tyr Asp Arg Met Arg Arg Gly Gly Asp Gly Tyr Asp
    130                 135                 140                 
Gly Gly Tyr Gly Gly Phe Asp Asp Tyr Gly Gly Tyr Asn Asn Tyr Gly
145                 150                 155                 160 
Tyr Gly Asn Asp Gly Phe Asp Asp Arg Met Arg Asp Gly Arg Gly Met
                165                 170                 175     
Gly Gly His Gly Tyr Gly Gly Ala Gly Asp Ala Ser Ser Gly Phe His
            180                 185                 190         
Gly Gly His Phe Val His Met Arg Gly Leu Pro Phe Arg Ala Thr Glu
        195                 200                 205             
Asn Asp Ile Ala Asn Phe Phe Ser Pro Leu Asn Pro Ile Arg Val His
    210                 215                 220                 
Ile Asp Ile Gly Ala Asp Gly Arg Ala Thr Gly Glu Ala Asp Val Glu
225                 230                 235                 240 
Phe Val Thr His Glu Asp Ala Val Ala Ala Met Ser Lys Asp Lys Asn
                245                 250                 255     
Asn Met Gln His Arg Tyr Ile Glu Leu Phe Leu Asn Ser Thr Pro Gly
            260                 265                 270         
Gly Gly Ser Gly Met Gly Gly Ser Gly Met Gly Gly Tyr Gly Arg Asp
        275                 280                 285             
Gly Met Asp Asn Gln Gly Gly Tyr Gly Ser Val Gly Arg Met Gly Met
    290                 295                 300                 
Gly Asn Asn Tyr Ser Gly Gly Tyr Gly Thr Pro Asp Gly Leu Gly Gly
305                 310                 315                 320 
Tyr Gly Arg Gly Gly Gly Gly Ser Gly Gly Tyr Tyr Gly Gln Gly Gly
                325                 330                 335     
Met Ser Gly Gly Gly Trp Arg Gly Met Tyr
            340                 345     


<210> 1815
<211> 805
<212> PRT
<213> Homo sapiens

<400> 1815
Met Ala Asn Val Ser Lys Lys Val Ser Trp Ser Gly Arg Asp Arg Asp
 1               5                  10                  15      
Asp Glu Glu Ala Ala Pro Leu Leu Arg Arg Thr Ala Arg Pro Gly Gly
            20                  25                  30          
Gly Thr Pro Leu Leu Asn Gly Ala Gly Pro Gly Ala Ala Arg Gln Ser
        35                  40                  45              
Pro Arg Ser Ala Leu Phe Arg Val Gly His Met Ser Ser Val Glu Leu
    50                  55                  60                  
Asp Asp Glu Leu Leu Asp Pro Asp Met Asp Pro Pro His Pro Phe Pro
65                  70                  75                  80  
Lys Glu Ile Pro His Asn Glu Lys Leu Leu Ser Leu Lys Tyr Glu Ser
                85                  90                  95      
Leu Asp Tyr Asp Asn Ser Glu Asn Gln Leu Phe Leu Glu Glu Glu Arg
            100                 105                 110         
Arg Ile Asn His Thr Ala Phe Arg Thr Val Glu Ile Lys Arg Trp Val
        115                 120                 125             
Ile Cys Ala Leu Ile Gly Ile Leu Thr Gly Leu Val Ala Cys Phe Ile
    130                 135                 140                 
Asp Ile Val Val Glu Asn Leu Ala Gly Leu Lys Tyr Arg Val Ile Lys
145                 150                 155                 160 
Gly Asn Ile Asp Lys Phe Thr Glu Lys Gly Gly Leu Ser Phe Ser Leu
                165                 170                 175     
Leu Leu Trp Ala Thr Leu Asn Ala Ala Phe Val Leu Val Gly Ser Val
            180                 185                 190         
Ile Val Ala Phe Ile Glu Pro Val Ala Ala Gly Ser Gly Ile Pro Gln
        195                 200                 205             
Ile Lys Cys Phe Leu Asn Gly Val Lys Ile Pro His Val Val Arg Leu
    210                 215                 220                 
Lys Thr Leu Val Ile Lys Val Ser Gly Val Ile Leu Ser Val Val Gly
225                 230                 235                 240 
Gly Leu Ala Val Gly Lys Glu Gly Pro Met Ile His Ser Gly Ser Val
                245                 250                 255     
Ile Ala Ala Gly Ile Ser Gln Gly Arg Ser Thr Ser Leu Lys Arg Asp
            260                 265                 270         
Phe Lys Ile Phe Glu Tyr Phe Arg Arg Asp Thr Glu Lys Arg Asp Phe
        275                 280                 285             
Val Ser Ala Gly Ala Ala Ala Gly Val Ser Ala Ala Phe Gly Ala Pro
    290                 295                 300                 
Val Gly Gly Val Leu Phe Ser Leu Glu Glu Gly Ala Ser Phe Trp Asn
305                 310                 315                 320 
Gln Phe Leu Thr Trp Arg Ile Phe Phe Ala Ser Met Ile Ser Thr Phe
                325                 330                 335     
Thr Leu Asn Phe Val Leu Ser Ile Tyr His Gly Asn Met Trp Asp Leu
            340                 345                 350         
Ser Ser Pro Gly Leu Ile Asn Phe Gly Arg Phe Asp Ser Glu Lys Met
        355                 360                 365             
Ala Tyr Thr Ile His Glu Ile Pro Val Phe Ile Ala Met Gly Val Val
    370                 375                 380                 
Gly Gly Val Leu Gly Ala Val Phe Asn Ala Leu Asn Tyr Trp Leu Thr
385                 390                 395                 400 
Met Phe Arg Ile Arg Tyr Ile His Arg Pro Cys Leu Gln Val Ile Glu
                405                 410                 415     
Ala Val Leu Val Ala Ala Val Thr Ala Thr Val Ala Phe Val Leu Ile
            420                 425                 430         
Tyr Ser Ser Arg Asp Cys Gln Pro Leu Gln Gly Gly Ser Met Ser Tyr
        435                 440                 445             
Pro Leu Gln Leu Phe Cys Ala Asp Gly Glu Tyr Asn Ser Met Ala Ala
    450                 455                 460                 
Ala Phe Phe Asn Thr Pro Glu Lys Ser Val Val Ser Leu Phe His Asp
465                 470                 475                 480 
Pro Pro Gly Ser Tyr Asn Pro Leu Thr Leu Gly Leu Phe Thr Leu Val
                485                 490                 495     
Tyr Phe Phe Leu Ala Cys Trp Thr Tyr Gly Leu Thr Val Ser Ala Gly
            500                 505                 510         
Val Phe Ile Pro Ser Leu Leu Ile Gly Ala Ala Trp Gly Arg Leu Phe
        515                 520                 525             
Gly Ile Ser Leu Ser Tyr Leu Thr Gly Ala Ala Ile Trp Ala Asp Pro
    530                 535                 540                 
Gly Lys Tyr Ala Leu Met Gly Ala Ala Ala Gln Leu Gly Gly Ile Val
545                 550                 555                 560 
Arg Met Thr Leu Ser Leu Thr Val Ile Met Met Glu Ala Thr Ser Asn
                565                 570                 575     
Val Thr Tyr Gly Phe Pro Ile Met Leu Val Leu Met Thr Ala Lys Ile
            580                 585                 590         
Val Gly Asp Val Phe Ile Glu Gly Leu Tyr Asp Met His Ile Gln Leu
        595                 600                 605             
Gln Ser Val Pro Phe Leu His Trp Glu Ala Pro Val Thr Ser His Ser
    610                 615                 620                 
Leu Thr Ala Arg Glu Val Met Ser Thr Pro Val Thr Cys Leu Arg Arg
625                 630                 635                 640 
Arg Glu Lys Val Gly Val Ile Val Asp Val Leu Ser Asp Thr Ala Ser
                645                 650                 655     
Asn His Asn Gly Phe Pro Val Val Glu His Ala Asp Asp Thr Gln Pro
            660                 665                 670         
Ala Arg Leu Gln Gly Leu Ile Leu Arg Ser Gln Leu Ile Val Leu Leu
        675                 680                 685             
Lys His Lys Val Phe Val Glu Arg Ser Asn Leu Gly Leu Val Gln Arg
    690                 695                 700                 
Arg Leu Arg Leu Lys Asp Phe Arg Asp Ala Tyr Pro Arg Phe Pro Pro
705                 710                 715                 720 
Ile Gln Ser Ile His Val Ser Gln Asp Glu Arg Glu Cys Thr Met Asp
                725                 730                 735     
Leu Ser Glu Phe Met Asn Pro Ser Pro Tyr Thr Val Pro Gln Glu Ala
            740                 745                 750         
Ser Leu Pro Arg Val Phe Lys Leu Phe Arg Ala Leu Gly Leu Arg His
        755                 760                 765             
Leu Val Val Val Asp Asn Arg Asn Gln Val Val Gly Leu Val Thr Arg
    770                 775                 780                 
Lys Asp Leu Ala Arg Tyr Arg Leu Gly Lys Arg Gly Leu Glu Glu Leu
785                 790                 795                 800 
Ser Leu Ala Gln Thr
                805 


<210> 1816
<211> 213
<212> PRT
<213> Homo sapiens

<400> 1816
Met Ala Val Leu Ser Ala Pro Gly Leu Arg Gly Phe Arg Ile Leu Gly
 1               5                  10                  15      
Leu Arg Ser Ser Val Gly Pro Ala Val Gln Ala Arg Gly Val His Gln
            20                  25                  30          
Ser Val Ala Thr Asp Gly Pro Ser Ser Thr Gln Pro Ala Leu Pro Lys
        35                  40                  45              
Ala Arg Ala Val Ala Pro Lys Pro Ser Ser Arg Gly Glu Tyr Val Val
    50                  55                  60                  
Ala Lys Leu Asp Asp Leu Val Asn Trp Ala Arg Arg Ser Ser Leu Trp
65                  70                  75                  80  
Pro Met Thr Phe Gly Leu Ala Cys Cys Ala Val Glu Met Met His Met
                85                  90                  95      
Ala Ala Pro Arg Tyr Asp Met Asp Arg Phe Gly Val Val Phe Arg Ala
            100                 105                 110         
Ser Pro Arg Gln Ser Asp Val Met Ile Val Ala Gly Thr Leu Thr Asn
        115                 120                 125             
Lys Met Ala Pro Ala Leu Arg Lys Val Tyr Asp Gln Met Pro Glu Pro
    130                 135                 140                 
Arg Tyr Val Val Ser Met Gly Ser Cys Ala Asn Gly Gly Gly Tyr Tyr
145                 150                 155                 160 
His Tyr Ser Tyr Ser Val Val Arg Gly Cys Asp Arg Ile Val Pro Val
                165                 170                 175     
Asp Ile Tyr Ile Pro Gly Cys Pro Pro Thr Ala Glu Ala Leu Leu Tyr
            180                 185                 190         
Gly Ile Leu Gln Leu Gln Arg Lys Ile Lys Arg Glu Arg Arg Leu Gln
        195                 200                 205             
Ile Trp Tyr Arg Arg
    210             


<210> 1817
<211> 542
<212> PRT
<213> Homo sapiens

<400> 1817
Met Ala Thr Ala Thr Ile Ala Leu Gln Val Asn Gly Gln Gln Gly Gly
 1               5                  10                  15      
Gly Ser Glu Pro Ala Ala Ala Ala Ala Val Val Ala Ala Gly Asp Lys
            20                  25                  30          
Trp Lys Pro Pro Gln Gly Thr Asp Ser Ile Lys Met Glu Asn Gly Gln
        35                  40                  45              
Ser Thr Ala Ala Lys Leu Gly Leu Pro Pro Leu Thr Pro Glu Gln Gln
    50                  55                  60                  
Glu Ala Leu Gln Lys Ala Lys Lys Tyr Ala Met Glu Gln Ser Ile Lys
65                  70                  75                  80  
Ser Val Leu Val Lys Gln Thr Ile Ala His Gln Gln Gln Gln Leu Thr
                85                  90                  95      
Asn Leu Gln Met Ala Ala Gln Arg Gln Gly Ala Leu Ala Ile Met Cys
            100                 105                 110         
Arg Val Tyr Val Gly Ser Ile Tyr Tyr Glu Leu Gly Glu Asp Thr Ile
        115                 120                 125             
Arg Gln Ala Phe Ala Pro Phe Gly Pro Ile Lys Ser Ile Asp Met Ser
    130                 135                 140                 
Trp Asp Ser Val Thr Met Lys His Lys Gly Phe Ala Phe Val Glu Tyr
145                 150                 155                 160 
Glu Val Pro Glu Ala Ala Gln Leu Ala Leu Glu Gln Met Asn Ser Val
                165                 170                 175     
Met Leu Gly Gly Arg Asn Ile Lys Val Gly Arg Pro Ser Asn Ile Gly
            180                 185                 190         
Gln Ala Gln Pro Ile Ile Asp Gln Leu Ala Glu Glu Ala Arg Ala Phe
        195                 200                 205             
Asn Arg Ile Tyr Val Ala Ser Val His Gln Asp Leu Ser Asp Asp Asp
    210                 215                 220                 
Ile Lys Ser Val Phe Glu Ala Phe Gly Lys Ile Lys Ser Cys Thr Leu
225                 230                 235                 240 
Ala Arg Asp Pro Thr Thr Gly Lys His Lys Gly Tyr Gly Phe Ile Glu
                245                 250                 255     
Tyr Glu Lys Ala Gln Ser Ser Gln Asp Ala Val Ser Ser Met Asn Leu
            260                 265                 270         
Phe Asp Leu Gly Gly Gln Tyr Leu Arg Val Gly Lys Ala Val Thr Pro
        275                 280                 285             
Pro Met Pro Leu Leu Thr Pro Ala Thr Pro Gly Gly Leu Pro Pro Ala
    290                 295                 300                 
Ala Ala Val Ala Ala Ala Ala Ala Thr Ala Lys Ile Thr Ala Gln Glu
305                 310                 315                 320 
Ala Val Ala Gly Ala Ala Val Leu Gly Thr Leu Gly Thr Pro Gly Leu
                325                 330                 335     
Val Ser Pro Ala Leu Thr Leu Ala Gln Pro Leu Gly Thr Leu Pro Gln
            340                 345                 350         
Ala Val Met Ala Ala Gln Ala Pro Gly Val Ile Thr Gly Val Thr Pro
        355                 360                 365             
Ala Arg Pro Pro Ile Pro Val Thr Ile Pro Ser Val Gly Val Val Asn
    370                 375                 380                 
Pro Ile Leu Ala Ser Pro Pro Thr Leu Gly Leu Leu Glu Pro Lys Lys
385                 390                 395                 400 
Glu Lys Glu Glu Glu Glu Leu Phe Pro Glu Ser Glu Arg Pro Glu Met
                405                 410                 415     
Leu Ser Glu Gln Glu His Met Ser Ile Ser Gly Ser Ser Ala Arg His
            420                 425                 430         
Met Val Met Gln Lys Leu Leu Arg Lys Gln Glu Ser Thr Val Met Val
        435                 440                 445             
Leu Arg Asn Met Val Asp Pro Lys Asp Ile Asp Asp Asp Leu Glu Gly
    450                 455                 460                 
Glu Val Thr Glu Glu Cys Gly Lys Phe Gly Ala Val Asn Arg Val Ile
465                 470                 475                 480 
Ile Tyr Gln Glu Lys Gln Gly Glu Glu Glu Asp Ala Glu Ile Ile Val
                485                 490                 495     
Lys Ile Phe Val Glu Phe Ser Ile Ala Ser Glu Thr His Lys Ala Ile
            500                 505                 510         
Gln Ala Leu Asn Gly Arg Trp Phe Ala Gly Arg Lys Val Val Ala Glu
        515                 520                 525             
Val Tyr Asp Gln Glu Arg Phe Asp Asn Ser Asp Leu Ser Ala
    530                 535                 540         


<210> 1818
<211> 1240
<212> PRT
<213> Homo sapiens

<400> 1818
Met Trp Pro Ser Gln Leu Leu Ile Phe Met Met Leu Leu Ala Pro Ile
 1               5                  10                  15      
Ile His Ala Phe Ser Arg Ala Pro Ile Pro Met Ala Val Val Arg Arg
            20                  25                  30          
Glu Leu Ser Cys Glu Ser Tyr Pro Ile Glu Leu Arg Cys Pro Gly Thr
        35                  40                  45              
Asp Val Ile Met Ile Glu Ser Ala Asn Tyr Gly Arg Thr Asp Asp Lys
    50                  55                  60                  
Ile Cys Asp Ser Asp Pro Ala Gln Met Glu Asn Ile Arg Cys Tyr Leu
65                  70                  75                  80  
Pro Asp Ala Tyr Lys Ile Met Ser Gln Arg Cys Asn Asn Arg Thr Gln
                85                  90                  95      
Cys Ala Val Val Ala Gly Pro Asp Val Phe Pro Asp Pro Cys Pro Gly
            100                 105                 110         
Thr Tyr Lys Tyr Leu Glu Val Gln Tyr Glu Cys Val Pro Tyr Lys Val
        115                 120                 125             
Glu Gln Lys Val Phe Leu Cys Pro Gly Leu Leu Lys Gly Val Tyr Gln
    130                 135                 140                 
Ser Glu His Leu Phe Glu Ser Asp His Gln Ser Gly Ala Trp Cys Lys
145                 150                 155                 160 
Asp Pro Leu Gln Ala Ser Asp Lys Ile Tyr Tyr Met Pro Trp Thr Pro
                165                 170                 175     
Tyr Arg Thr Asp Thr Leu Thr Glu Tyr Ser Ser Lys Asp Asp Phe Ile
            180                 185                 190         
Ala Gly Arg Pro Thr Thr Thr Tyr Lys Leu Pro His Arg Val Asp Gly
        195                 200                 205             
Thr Gly Phe Val Val Tyr Asp Gly Ala Leu Phe Phe Asn Lys Glu Arg
    210                 215                 220                 
Thr Arg Asn Ile Val Lys Phe Asp Leu Arg Thr Arg Ile Lys Ser Gly
225                 230                 235                 240 
Glu Ala Ile Ile Ala Asn Ala Asn Tyr His Asp Thr Ser Pro Tyr Arg
                245                 250                 255     
Trp Gly Gly Lys Ser Asp Ile Asp Leu Ala Val Asp Glu Asn Gly Leu
            260                 265                 270         
Trp Val Ile Tyr Ala Thr Glu Gln Asn Asn Gly Lys Ile Val Ile Ser
        275                 280                 285             
Gln Leu Asn Pro Tyr Thr Leu Arg Ile Glu Gly Thr Trp Asp Thr Ala
    290                 295                 300                 
Tyr Asp Lys Arg Ser Ala Ser Asn Ala Phe Met Ile Cys Gly Ile Leu
305                 310                 315                 320 
Tyr Val Val Lys Ser Val Tyr Glu Asp Asp Asp Asn Glu Ala Thr Gly
                325                 330                 335     
Asn Lys Ile Asp Tyr Ile Tyr Asn Thr Asp Gln Ser Lys Asp Ser Leu
            340                 345                 350         
Val Asp Val Pro Phe Pro Asn Ser Tyr Gln Tyr Ile Ala Ala Val Asp
        355                 360                 365             
Tyr Asn Pro Arg Asp Asn Leu Leu Tyr Val Trp Asn Asn Tyr His Val
    370                 375                 380                 
Val Lys Tyr Ser Leu Asp Phe Gly Pro Leu Asp Ser Arg Ser Gly Gln
385                 390                 395                 400 
Ala His His Gly Gln Val Ser Tyr Ile Ser Pro Pro Ile His Leu Asp
                405                 410                 415     
Ser Glu Leu Glu Arg Pro Ser Val Lys Asp Ile Ser Thr Thr Gly Pro
            420                 425                 430         
Leu Gly Met Gly Ser Thr Thr Thr Ser Thr Thr Leu Arg Thr Thr Thr
        435                 440                 445             
Leu Ser Pro Gly Arg Ser Thr Thr Pro Ser Val Ser Gly Arg Arg Asn
    450                 455                 460                 
Arg Ser Thr Ser Thr Pro Ser Pro Ala Val Glu Val Leu Asp Asp Met
465                 470                 475                 480 
Thr Thr His Leu Pro Ser Ala Ser Ser Gln Ile Pro Ala Leu Glu Glu
                485                 490                 495     
Ser Cys Glu Ala Val Glu Ala Arg Glu Ile Met Trp Phe Lys Thr Arg
            500                 505                 510         
Gln Gly Gln Ile Ala Lys Gln Pro Cys Pro Ala Gly Thr Ile Gly Val
        515                 520                 525             
Ser Thr Tyr Leu Cys Leu Ala Pro Asp Gly Ile Trp Asp Pro Gln Gly
    530                 535                 540                 
Pro Asp Leu Ser Asn Cys Ser Ser Pro Trp Val Asn His Ile Thr Gln
545                 550                 555                 560 
Lys Leu Lys Ser Gly Glu Thr Ala Ala Asn Ile Ala Arg Glu Leu Ala
                565                 570                 575     
Glu Gln Thr Arg Asn His Leu Asn Ala Gly Asp Ile Thr Tyr Ser Val
            580                 585                 590         
Arg Ala Met Asp Gln Leu Val Gly Leu Leu Asp Val Gln Leu Arg Asn
        595                 600                 605             
Leu Thr Pro Gly Gly Lys Asp Ser Ala Ala Arg Ser Leu Asn Lys Leu
    610                 615                 620                 
Gln Lys Arg Glu Arg Ser Cys Arg Ala Tyr Val Gln Ala Met Val Glu
625                 630                 635                 640 
Thr Val Asn Asn Leu Leu Gln Pro Gln Ala Leu Asn Ala Trp Arg Asp
                645                 650                 655     
Leu Thr Thr Ser Asp Gln Leu Arg Ala Ala Thr Met Leu Leu His Thr
            660                 665                 670         
Val Glu Glu Ser Ala Phe Val Leu Ala Asp Asn Leu Leu Lys Thr Asp
        675                 680                 685             
Ile Val Arg Glu Asn Thr Asp Asn Ile Lys Leu Glu Val Ala Arg Leu
    690                 695                 700                 
Ser Thr Glu Gly Asn Leu Glu Asp Leu Lys Phe Pro Glu Asn Met Gly
705                 710                 715                 720 
His Gly Ser Thr Ile Gln Leu Ser Ala Asn Thr Leu Lys Gln Asn Gly
                725                 730                 735     
Arg Asn Gly Glu Ile Arg Val Ala Phe Val Leu Tyr Asn Asn Leu Gly
            740                 745                 750         
Pro Tyr Leu Ser Thr Glu Asn Ala Ser Met Lys Leu Gly Thr Glu Ala
        755                 760                 765             
Leu Ser Thr Asn His Ser Val Ile Val Asn Ser Pro Val Ile Thr Ala
    770                 775                 780                 
Ala Ile Asn Lys Glu Phe Ser Asn Lys Val Tyr Leu Ala Asp Pro Val
785                 790                 795                 800 
Val Phe Thr Val Lys His Ile Lys Gln Ser Glu Glu Asn Phe Asn Pro
                805                 810                 815     
Asn Cys Ser Phe Trp Ser Tyr Ser Lys Arg Thr Met Thr Gly Tyr Trp
            820                 825                 830         
Ser Thr Gln Gly Cys Arg Leu Leu Thr Thr Asn Lys Thr His Thr Thr
        835                 840                 845             
Cys Ser Cys Asn His Leu Thr Asn Phe Ala Val Leu Met Ala His Val
    850                 855                 860                 
Glu Val Lys His Ser Asp Ala Val His Asp Leu Leu Leu Asp Val Ile
865                 870                 875                 880 
Thr Trp Val Gly Ile Leu Leu Ser Leu Val Cys Leu Leu Ile Cys Ile
                885                 890                 895     
Phe Thr Phe Cys Phe Phe Arg Gly Leu Gln Ser Asp Arg Asn Thr Ile
            900                 905                 910         
His Lys Asn Leu Cys Ile Ser Leu Phe Val Ala Glu Leu Leu Phe Leu
        915                 920                 925             
Ile Gly Ile Asn Arg Thr Asp Gln Pro Ile Ala Cys Ala Val Phe Ala
    930                 935                 940                 
Ala Leu Leu His Phe Phe Phe Leu Ala Ala Phe Thr Trp Met Phe Leu
945                 950                 955                 960 
Glu Gly Val Gln Leu Tyr Ile Met Leu Val Glu Val Phe Glu Ser Glu
                965                 970                 975     
His Ser Arg Arg Lys Tyr Phe Tyr Leu Val Gly Tyr Gly Met Pro Ala
            980                 985                 990         
Leu Ile Val Ala Val Ser Ala Ala Val Asp Tyr Arg Ser Tyr Gly Thr
        995                 1000                1005            
Asp Lys Val Cys Trp Leu Arg Leu Asp Thr Tyr Phe Ile Trp Ser Phe
    1010                1015                1020                
Ile Gly Pro Ala Thr Leu Ile Ile Met Leu Asn Val Ile Phe Leu Gly
1025                1030                1035                1040
Ile Ala Leu Tyr Lys Met Phe His His Thr Ala Ile Leu Lys Pro Glu
                1045                1050                1055    
Ser Gly Cys Leu Asp Asn Ile Asn Tyr Glu Asp Asn Arg Pro Phe Ile
            1060                1065                1070        
Lys Ser Trp Val Ile Gly Ala Ile Ala Leu Leu Cys Leu Leu Gly Leu
        1075                1080                1085            
Thr Trp Ala Phe Gly Leu Met Tyr Ile Asn Glu Ser Thr Val Ile Met
    1090                1095                1100                
Ala Tyr Leu Phe Thr Ile Phe Asn Ser Leu Gln Gly Met Phe Ile Phe
1105                1110                1115                1120
Ile Phe His Cys Val Leu Gln Lys Lys Val Arg Lys Glu Tyr Gly Lys
                1125                1130                1135    
Cys Leu Arg Thr His Cys Cys Ser Gly Lys Ser Thr Glu Ser Ser Ile
            1140                1145                1150        
Gly Ser Gly Lys Thr Ser Gly Ser Arg Thr Pro Gly Arg Tyr Ser Thr
        1155                1160                1165            
Gly Ser Gln Ser Arg Ile Arg Arg Met Trp Asn Asp Thr Val Arg Lys
    1170                1175                1180                
Gln Ser Glu Ser Ser Phe Ile Thr Gly Asp Ile Asn Ser Ser Ala Ser
1185                1190                1195                1200
Leu Asn Arg Glu Pro Tyr Arg Glu Thr Ser Met Gly Val Lys Leu Asn
                1205                1210                1215    
Ile Ala Tyr Gln Ile Gly Ala Ser Glu Gln Cys Gln Gly Tyr Lys Cys
            1220                1225                1230        
His Gly Tyr Ser Thr Thr Glu Trp
        1235                1240


<210> 1819
<211> 486
<212> PRT
<213> Homo sapiens

<400> 1819
Met Ile Ser Pro Ser Pro Ser Gln Glu Glu Leu Gln Thr Thr Leu Glu
 1               5                  10                  15      
Glu Thr Asp Gln Ser Thr Gln Glu Pro Phe Thr Thr Lys Ile Pro Arg
            20                  25                  30          
Thr Thr Glu Leu Ala Lys Thr Thr Gln Ala Pro His Arg Phe Tyr Thr
        35                  40                  45              
Thr Val Arg Pro Arg Thr Ser Asp Lys Pro His Ile Arg Pro Val Leu
    50                  55                  60                  
Asn Arg Thr Thr Thr Arg Pro Thr Arg Pro Lys Pro Ser Gly Met Pro
65                  70                  75                  80  
Ser Gly Asn Gly Val Gly Thr Gly Val Lys Gln Ala Pro Arg Pro Ser
                85                  90                  95      
Gly Ala Asp Arg Asn Val Ser Val Asp Ser Thr His Pro Thr Lys Lys
            100                 105                 110         
Pro Gly Thr Arg Arg Pro Pro Leu Pro Pro Arg Pro Thr His Pro Arg
        115                 120                 125             
Arg Lys Pro Leu Pro Pro Asn Asn Val Thr Gly Lys Pro Gly Ser Ala
    130                 135                 140                 
Gly Ile Ile Ser Ser Gly Pro Ile Thr Thr Pro Pro Leu Arg Ser Thr
145                 150                 155                 160 
Pro Arg Pro Thr Gly Thr Pro Leu Glu Arg Ile Glu Thr Asp Ile Lys
                165                 170                 175     
Gln Pro Thr Val Pro Ala Ser Gly Glu Glu Leu Glu Asn Ile Thr Asp
            180                 185                 190         
Phe Ser Ser Ser Pro Thr Arg Glu Thr Asp Pro Leu Gly Lys Pro Arg
        195                 200                 205             
Phe Lys Gly Pro His Val Arg Tyr Ile Gln Lys Pro Asp Asn Ser Pro
    210                 215                 220                 
Cys Ser Ile Thr Asp Ser Val Lys Arg Phe Pro Lys Glu Glu Ala Thr
225                 230                 235                 240 
Glu Gly Asn Ala Thr Ser Pro Pro Gln Asn Pro Pro Thr Asn Leu Thr
                245                 250                 255     
Val Val Thr Val Glu Gly Cys Pro Ser Phe Val Ile Leu Asp Trp Glu
            260                 265                 270         
Lys Pro Leu Asn Asp Thr Val Thr Glu Tyr Glu Val Ile Ser Arg Glu
        275                 280                 285             
Asn Gly Ser Phe Ser Gly Lys Asn Lys Ser Ile Gln Met Thr Asn Gln
    290                 295                 300                 
Thr Phe Ser Thr Val Glu Asn Leu Lys Pro Asn Thr Ser Tyr Glu Phe
305                 310                 315                 320 
Gln Val Lys Pro Lys Asn Pro Leu Gly Glu Gly Pro Val Ser Asn Thr
                325                 330                 335     
Val Ala Phe Ser Thr Glu Ser Ala Asp Pro Arg Val Ser Glu Pro Val
            340                 345                 350         
Ser Ala Gly Arg Asp Ala Ile Trp Thr Glu Arg Pro Phe Asn Ser Asp
        355                 360                 365             
Ser Tyr Ser Glu Cys Lys Gly Lys Gln Tyr Val Lys Arg Thr Trp Tyr
    370                 375                 380                 
Lys Lys Phe Val Gly Val Gln Leu Cys Asn Ser Leu Arg Tyr Lys Ile
385                 390                 395                 400 
Tyr Leu Ser Asp Ser Leu Thr Gly Lys Phe Tyr Asn Ile Gly Asp Gln
                405                 410                 415     
Arg Gly His Gly Glu Asp His Cys Gln Phe Val Asp Ser Phe Leu Asp
            420                 425                 430         
Gly Arg Thr Gly Gln Gln Leu Thr Ser Asp Gln Leu Pro Ile Lys Glu
        435                 440                 445             
Gly Tyr Phe Arg Ala Val Arg Gln Glu Pro Val Gln Phe Gly Glu Ile
    450                 455                 460                 
Gly Gly His Thr Gln Ile Asn Tyr Val Gln Trp Tyr Glu Cys Gly Thr
465                 470                 475                 480 
Thr Ile Pro Gly Lys Trp
                485     


<210> 1820
<211> 507
<212> PRT
<213> Homo sapiens

<400> 1820
Met Cys Asp Ile Glu Glu Ala Thr Asn Gln Leu Leu Asp Val Asn Leu
 1               5                  10                  15      
His Glu Asn Gln Lys Ser Val Gln Val Thr Glu Ser Asp Leu Gly Ser
            20                  25                  30          
Glu Ser Glu Leu Leu Val Thr Ile Gly Ala Thr Val Pro Thr Gly Phe
        35                  40                  45              
Glu Gln Thr Ala Ala Asp Glu Val Arg Glu Lys Leu Gly Ser Ser Cys
    50                  55                  60                  
Lys Ile Ser Arg Asp Arg Gly Lys Ile Tyr Phe Val Ile Ser Val Glu
65                  70                  75                  80  
Ser Leu Ala Gln Val His Cys Leu Arg Ser Val Asp Asn Leu Phe Val
                85                  90                  95      
Val Val Gln Glu Phe Gln Asp Tyr Gln Phe Lys Gln Thr Lys Glu Glu
            100                 105                 110         
Val Leu Lys Asp Phe Glu Asp Leu Ala Gly Lys Leu Pro Trp Ser Asn
        115                 120                 125             
Pro Leu Lys Val Trp Lys Ile Asn Ala Ser Phe Lys Lys Lys Lys Ala
    130                 135                 140                 
Lys Arg Lys Lys Ile Asn Gln Asn Ser Ser Lys Glu Lys Ile Asn Asn
145                 150                 155                 160 
Gly Gln Glu Val Lys Ile Asp Gln Arg Asn Val Lys Lys Glu Phe Thr
                165                 170                 175     
Ser His Ala Leu Asp Ser His Ile Leu Asp Tyr Tyr Glu Asn Pro Ala
            180                 185                 190         
Ile Lys Glu Asp Val Ser Thr Leu Ile Gly Asp Asp Leu Ala Ser Cys
        195                 200                 205             
Lys Asp Glu Thr Asp Glu Ser Ser Lys Glu Glu Thr Glu Pro Gln Val
    210                 215                 220                 
Leu Lys Phe Arg Val Thr Cys Asn Arg Ala Gly Glu Lys His Cys Phe
225                 230                 235                 240 
Thr Ser Asn Glu Ala Ala Arg Asp Phe Gly Gly Ala Val Gln Asp Tyr
                245                 250                 255     
Phe Lys Trp Lys Ala Asp Met Thr Asn Phe Asp Val Glu Val Leu Leu
            260                 265                 270         
Asn Ile His Asp Asn Glu Val Ile Val Gly Ile Ala Leu Thr Glu Glu
        275                 280                 285             
Ser Leu His Arg Arg Asn Ile Thr His Phe Gly Pro Thr Thr Leu Arg
    290                 295                 300                 
Ser Thr Leu Ala Tyr Gly Met Leu Arg Leu Cys Asp Pro Leu Pro Tyr
305                 310                 315                 320 
Asp Ile Ile Val Asp Pro Met Cys Gly Thr Gly Ala Ile Pro Ile Glu
                325                 330                 335     
Gly Ala Thr Glu Trp Ser Asp Cys Phe His Ile Ala Gly Asp Asn Asn
            340                 345                 350         
Pro Leu Ala Val Asn Arg Ala Ala Asn Asn Ile Ala Ser Leu Leu Thr
        355                 360                 365             
Lys Ser Gln Ile Lys Glu Gly Lys Pro Ser Trp Gly Leu Pro Ile Asp
    370                 375                 380                 
Ala Val Gln Trp Asp Ile Cys Asn Leu Pro Leu Arg Thr Gly Ser Val
385                 390                 395                 400 
Asp Ile Ile Val Thr Asp Leu Pro Phe Gly Lys Arg Met Gly Ser Lys
                405                 410                 415     
Lys Arg Asn Trp Asn Leu Tyr Pro Ala Cys Leu Arg Glu Met Ser Arg
            420                 425                 430         
Val Cys Thr Pro Thr Thr Gly Arg Ala Val Leu Leu Thr Gln Asp Thr
        435                 440                 445             
Lys Cys Phe Thr Lys Ala Leu Ser Gly Met Gln His Val Trp Arg Lys
    450                 455                 460                 
Val Asp Thr Val Trp Val Asn Val Gly Gly Leu Arg Ala Ala Val Tyr
465                 470                 475                 480 
Val Leu Ile Arg Thr Pro Gln Ala Phe Val His Pro Ser Glu Gln Asp
                485                 490                 495     
Gly Glu Arg Gly Thr Leu Trp Gln Cys Lys Glu
            500                 505         


<210> 1821
<211> 205
<212> PRT
<213> Homo sapiens

<400> 1821
Met Ser Lys Lys Lys Gly Leu Ser Ala Glu Glu Lys Arg Thr Arg Met
 1               5                  10                  15      
Met Glu Ile Phe Ser Glu Thr Lys Asp Val Phe Gln Leu Lys Asp Leu
            20                  25                  30          
Glu Lys Ile Ala Pro Lys Glu Lys Gly Ile Thr Ala Met Ser Val Lys
        35                  40                  45              
Glu Val Leu Gln Ser Leu Val Asp Asp Gly Met Val Asp Cys Glu Arg
    50                  55                  60                  
Ile Gly Thr Ser Asn Tyr Tyr Trp Ala Phe Pro Ser Lys Ala Leu His
65                  70                  75                  80  
Ala Arg Lys His Lys Leu Glu Val Leu Glu Ser Gln Leu Ser Glu Gly
                85                  90                  95      
Ser Gln Lys His Ala Ser Leu Gln Lys Ser Ile Glu Lys Ala Lys Ile
            100                 105                 110         
Gly Arg Cys Glu Thr Glu Glu Arg Thr Arg Leu Ala Lys Glu Leu Ser
        115                 120                 125             
Ser Leu Arg Asp Gln Arg Glu Gln Leu Lys Ala Glu Val Glu Lys Tyr
    130                 135                 140                 
Lys Asp Cys Asp Pro Gln Val Val Glu Glu Ile Arg Gln Ala Asn Lys
145                 150                 155                 160 
Val Ala Lys Glu Ala Ala Asn Arg Trp Thr Asp Asn Ile Phe Ala Ile
                165                 170                 175     
Lys Ser Trp Ala Lys Arg Lys Phe Gly Phe Glu Glu Asn Lys Ile Asp
            180                 185                 190         
Arg Thr Phe Gly Ile Pro Glu Asp Phe Asp Tyr Ile Asp
        195                 200                 205 


<210> 1822
<211> 893
<212> PRT
<213> Homo sapiens

<400> 1822
Met Glu Lys Asp Asp Pro Pro Gln Leu Val Thr Pro Thr Ser Val Lys
 1               5                  10                  15      
Ala Ile Ile Leu Arg Ile Glu Ala Ala Gln Leu Thr Arg Ala Gln Glu
            20                  25                  30          
Asp Ile Ser Thr Gln Leu Ser Asp Ile Leu Asp Asn Val Asn Cys Val
        35                  40                  45              
Ile Asn Arg Phe Gln Glu Glu Leu Gly Tyr Asp Leu Lys Glu Asn Ala
    50                  55                  60                  
Lys Ser Gln Gln Arg Asp Pro Lys Gly Lys Lys Arg Phe Ile Leu Leu
65                  70                  75                  80  
Glu Lys Ile Ala Ser Phe Ser Lys Asp Ala Met Met Lys Glu Lys His
                85                  90                  95      
Leu Tyr Asp Ile Leu Arg Trp Leu Gly Asp Trp Gly Asp Thr Leu Thr
            100                 105                 110         
Tyr Glu Ile Gly Pro Arg Lys Ser Glu Glu Glu Ala Ala Ala Leu Asp
        115                 120                 125             
Glu Trp Ile Glu Val Thr Glu Lys Val Leu Pro Leu Ser Leu Ile Ala
    130                 135                 140                 
Thr Lys Arg Gly Ile Glu Ser Leu Thr Ala Leu Cys Ser Thr Leu Ile
145                 150                 155                 160 
Glu Gly Gln Lys Lys Arg Ser Gln Val Ser Lys Arg Thr Phe Trp Gln
                165                 170                 175     
Gly Trp Gln Gly Arg Ser Pro Gln Thr Ser Pro Ser His Pro Gln Pro
            180                 185                 190         
Leu Ser Pro Glu Gln Met Leu Gln Asp Gln His Thr Met Asn Thr Lys
        195                 200                 205             
Ala Ser Glu Val Thr Ser Met Leu Gln Glu Leu Leu Asp Ser Thr Met
    210                 215                 220                 
Phe Ser Lys Gly Glu Val Arg Ala Ile Arg Tyr Met Ala Thr Val Val
225                 230                 235                 240 
Glu Asn Leu Asn Lys Ala Leu Ile Leu Gln His Lys Glu Asn Arg Ser
                245                 250                 255     
Leu Glu Thr Lys Tyr Arg His Leu Gln Met Gln Ala Thr Lys Glu Leu
            260                 265                 270         
Ser Ser Gln Arg Leu His Phe Gln Gln Phe Met Glu Val Leu Glu Ser
        275                 280                 285             
Arg Arg Asp Ala Leu Leu Lys Gln Val Glu Ile Leu Gly Gly Arg Tyr
    290                 295                 300                 
His Asp Leu Leu Leu Met Lys Gln Ala Leu Glu Phe Gln Leu Lys Lys
305                 310                 315                 320 
Ala Gln Asn Ala Thr Gly Gln Ala Glu Asp Leu Ala Glu Val Ser Val
                325                 330                 335     
Asp Ser Pro Gly Pro Ser Glu Arg Glu Thr Leu Pro Arg Lys Glu Thr
            340                 345                 350         
Val Met Glu Glu Ser Gln Gln Glu Pro Met Lys Glu Glu Gln Leu Phe
        355                 360                 365             
Ser Pro Leu Pro Pro Ser Pro Met Ala Met Ile Arg Asp Ser Gly Ala
    370                 375                 380                 
Ile Ala Ala Gly His Gln Pro Leu Ser Thr Met Thr Val Arg Ser Arg
385                 390                 395                 400 
Val Ala Asp Val Phe Gly Ser Lys Asp Thr Glu Ser Leu Glu Pro Val
                405                 410                 415     
Leu Leu Pro Leu Val Asp Arg Arg Phe Pro Lys Lys Trp Glu Arg Pro
            420                 425                 430         
Val Ala Glu Ser Leu Gly His Lys Asp Lys Asp Gln Glu Asp Tyr Phe
        435                 440                 445             
Gln Lys Gly Gly Leu Gln Ile Lys Phe His Cys Ser Lys Gln Leu Ser
    450                 455                 460                 
Leu Glu Ser Ser Arg Gln Val Thr Ser Glu Ser Gln Glu Glu Pro Trp
465                 470                 475                 480 
Glu Glu Glu Phe Gly Arg Glu Met Arg Arg Gln Leu Trp Leu Glu Glu
                485                 490                 495     
Glu Glu Met Trp Gln Gln Arg Gln Lys Lys Trp Ala Leu Leu Glu Gln
            500                 505                 510         
Glu His Gln Glu Lys Leu Arg Gln Trp Asn Leu Glu Asp Leu Ala Arg
        515                 520                 525             
Glu Gln Gln Arg Arg Trp Val Gln Leu Glu Lys Glu Gln Glu Ser Pro
    530                 535                 540                 
Arg Arg Glu Pro Glu Gln Leu Gly Glu Asp Val Glu Arg Arg Ile Phe
545                 550                 555                 560 
Thr Pro Thr Ser Arg Trp Arg Asp Leu Glu Lys Ala Glu Leu Ser Leu
                565                 570                 575     
Val Pro Ala Pro Ser Arg Thr Gln Ser Ala His Gln Ser Arg Arg Pro
            580                 585                 590         
His Leu Pro Met Ser Pro Ser Thr Gln Gln Pro Ala Leu Gly Lys Gln
        595                 600                 605             
Arg Pro Met Ser Ser Val Glu Phe Thr Tyr Arg Pro Arg Thr Arg Arg
    610                 615                 620                 
Val Pro Thr Lys Pro Lys Lys Ser Ala Ser Phe Pro Val Thr Gly Thr
625                 630                 635                 640 
Ser Ile Arg Arg Leu Thr Trp Pro Ser Leu Gln Ile Ser Pro Ala Asn
                645                 650                 655     
Ile Lys Lys Lys Val Tyr His Met Asp Met Glu Ala Gln Arg Lys Asn
            660                 665                 670         
Leu Gln Leu Leu Ser Glu Glu Ser Glu Leu Arg Leu Pro His Tyr Leu
        675                 680                 685             
Arg Ser Lys Ala Leu Glu Leu Thr Thr Thr Thr Met Glu Leu Gly Ala
    690                 695                 700                 
Leu Arg Leu Gln Tyr Leu Cys His Lys Tyr Ile Phe Tyr Arg Arg Leu
705                 710                 715                 720 
Gln Ser Leu Arg Gln Glu Ala Ile Asn His Val Gln Ile Met Lys Glu
                725                 730                 735     
Thr Glu Ala Ser Tyr Lys Ala Gln Asn Leu Tyr Ile Phe Leu Glu Asn
            740                 745                 750         
Ile Asp Arg Leu Gln Ser Leu Arg Leu Gln Ala Trp Thr Asp Lys Gln
        755                 760                 765             
Lys Gly Leu Glu Glu Lys His Arg Glu Cys Leu Ser Ser Met Val Thr
    770                 775                 780                 
Met Phe Pro Lys Leu Gln Leu Glu Trp Asn Val His Leu Asn Ile Pro
785                 790                 795                 800 
Glu Val Thr Ser Pro Lys Pro Lys Lys Cys Lys Leu Pro Ala Ala Ser
                805                 810                 815     
Pro Arg His Ile Arg Pro Ser Gly Pro Thr Tyr Lys Gln Pro Phe Leu
            820                 825                 830         
Ser Arg His Arg Ala Cys Val Pro Leu Gln Met Ala Arg Gln Gln Gly
        835                 840                 845             
Lys Gln Met Glu Ala Val Trp Lys Thr Glu Val Ala Ser Ser Ser Tyr
    850                 855                 860                 
Ala Ile Glu Lys Lys Thr Pro Ala Ser Leu Pro Arg Asp Gln Leu Arg
865                 870                 875                 880 
Gly His Pro Asp Ile Pro Arg Leu Leu Thr Leu Asp Val
                885                 890             


<210> 1823
<211> 564
<212> PRT
<213> Homo sapiens

<400> 1823
Met Ala Thr Ala Glu Arg Arg Ala Leu Gly Ile Gly Phe Gln Trp Leu
 1               5                  10                  15      
Ser Leu Ala Thr Leu Val Leu Ile Cys Ala Gly Gln Gly Gly Arg Arg
            20                  25                  30          
Glu Asp Gly Gly Pro Ala Cys Tyr Gly Gly Phe Asp Leu Tyr Phe Ile
        35                  40                  45              
Leu Asp Lys Ser Gly Ser Val Leu His His Trp Asn Glu Ile Tyr Tyr
    50                  55                  60                  
Phe Val Glu Gln Leu Ala His Lys Phe Ile Ser Pro Gln Leu Arg Met
65                  70                  75                  80  
Ser Phe Ile Val Phe Ser Thr Arg Gly Thr Thr Leu Met Lys Leu Thr
                85                  90                  95      
Glu Asp Arg Glu Gln Ile Arg Gln Gly Leu Glu Glu Leu Gln Lys Val
            100                 105                 110         
Leu Pro Gly Gly Asp Thr Tyr Met His Glu Gly Phe Glu Arg Ala Ser
        115                 120                 125             
Glu Gln Ile Tyr Tyr Glu Asn Arg Gln Gly Tyr Arg Thr Ala Ser Val
    130                 135                 140                 
Ile Ile Ala Leu Thr Asp Gly Glu Leu His Glu Asp Leu Phe Phe Tyr
145                 150                 155                 160 
Ser Glu Arg Glu Ala Asn Arg Ser Arg Asp Leu Gly Ala Ile Val Tyr
                165                 170                 175     
Cys Val Gly Val Lys Asp Phe Asn Glu Thr Gln Leu Ala Arg Ile Ala
            180                 185                 190         
Asp Ser Lys Asp His Val Phe Pro Val Asn Asp Gly Phe Gln Ala Leu
        195                 200                 205             
Gln Gly Ile Ile His Ser Ile Leu Lys Lys Ser Cys Ile Glu Ile Leu
    210                 215                 220                 
Ala Ala Glu Pro Ser Thr Ile Cys Ala Gly Glu Ser Phe Gln Val Val
225                 230                 235                 240 
Val Arg Gly Asn Gly Phe Arg His Ala Arg Asn Val Asp Arg Val Leu
                245                 250                 255     
Cys Ser Phe Lys Ile Asn Asp Ser Val Thr Leu Asn Glu Lys Pro Phe
            260                 265                 270         
Ser Val Glu Asp Thr Tyr Leu Leu Cys Pro Ala Pro Ile Leu Lys Glu
        275                 280                 285             
Val Gly Met Lys Ala Ala Leu Gln Val Ser Met Asn Asp Gly Leu Ser
    290                 295                 300                 
Phe Ile Ser Ser Ser Val Ile Ile Thr Thr Thr His Cys Ser Asp Gly
305                 310                 315                 320 
Ser Ile Leu Ala Ile Ala Leu Leu Ile Leu Phe Leu Leu Leu Ala Leu
                325                 330                 335     
Ala Leu Leu Trp Trp Phe Trp Pro Leu Cys Cys Thr Val Ile Ile Lys
            340                 345                 350         
Glu Val Pro Pro Pro Pro Ala Glu Glu Ser Glu Glu Glu Asp Asp Asp
        355                 360                 365             
Gly Leu Pro Lys Lys Lys Trp Pro Thr Val Asp Ala Ser Tyr Tyr Gly
    370                 375                 380                 
Gly Arg Gly Val Gly Gly Ile Lys Arg Met Glu Val Arg Trp Gly Glu
385                 390                 395                 400 
Lys Gly Ser Thr Glu Glu Gly Ala Lys Leu Glu Lys Ala Lys Asn Ala
                405                 410                 415     
Arg Val Lys Met Pro Glu Gln Glu Tyr Glu Phe Pro Glu Pro Arg Asn
            420                 425                 430         
Leu Asn Asn Asn Met Arg Arg Pro Ser Ser Pro Arg Lys Trp Tyr Ser
        435                 440                 445             
Pro Ile Lys Gly Lys Leu Asp Ala Leu Trp Val Leu Leu Arg Lys Gly
    450                 455                 460                 
Tyr Asp Arg Val Ser Val Met Arg Pro Gln Pro Gly Asp Thr Gly Arg
465                 470                 475                 480 
Cys Ile Asn Phe Thr Arg Val Lys Asn Asn Gln Pro Ala Lys Tyr Pro
                485                 490                 495     
Leu Asn Asn Ala Tyr His Thr Ser Ser Pro Pro Pro Ala Pro Ile Tyr
            500                 505                 510         
Thr Pro Pro Pro Pro Ala Pro His Cys Pro Pro Pro Pro Pro Ser Ala
        515                 520                 525             
Pro Thr Pro Pro Ile Pro Ser Pro Pro Ser Thr Leu Pro Pro Pro Pro
    530                 535                 540                 
Gln Ala Pro Pro Pro Asn Arg Ala Pro Pro Pro Ser Arg Pro Pro Pro
545                 550                 555                 560 
Arg Pro Ser Val
                


<210> 1824
<211> 823
<212> PRT
<213> Homo sapiens

<400> 1824
Met Lys Leu Phe Gly Phe Gly Ser Arg Arg Gly Gln Thr Ala Gln Gly
 1               5                  10                  15      
Ser Ile Asp His Val Tyr Thr Gly Ser Gly Tyr Arg Ile Arg Asp Ser
            20                  25                  30          
Glu Leu Gln Lys Ile His Arg Ala Ala Val Lys Gly Asp Ala Ala Glu
        35                  40                  45              
Val Glu Arg Cys Leu Ala Arg Arg Ser Gly Asp Leu Asp Ala Leu Asp
    50                  55                  60                  
Lys Gln His Arg Thr Ala Leu His Leu Ala Cys Ala Ser Gly His Val
65                  70                  75                  80  
Gln Val Val Thr Leu Leu Val Asn Arg Lys Cys Gln Ile Asp Val Cys
                85                  90                  95      
Asp Lys Glu Asn Arg Thr Pro Leu Ile Gln Ala Val His Cys Gln Glu
            100                 105                 110         
Glu Ala Cys Ala Val Ile Leu Leu Glu His Gly Ala Asn Pro Asn Phe
        115                 120                 125             
Lys Asp Ile Tyr Gly Asn Thr Ala Leu His Tyr Ala Val Tyr Ser Glu
    130                 135                 140                 
Ser Thr Ser Leu Ala Glu Lys Leu Leu Ser His Gly Ala His Ile Glu
145                 150                 155                 160 
Ala Leu Asp Lys Asp Asn Asn Thr Pro Leu Leu Phe Ala Ile Ile Cys
                165                 170                 175     
Lys Lys Glu Lys Met Val Glu Phe Leu Leu Lys Lys Lys Ala Ser Ser
            180                 185                 190         
His Ala Val Asp Arg Leu Arg Arg Ser Ala Leu Met Leu Ala Val Tyr
        195                 200                 205             
Tyr Asp Ser Pro Gly Ile Val Asn Ile Leu Leu Lys Gln Asn Ile Asp
    210                 215                 220                 
Val Phe Ala Gln Asp Met Cys Gly Arg Asp Ala Glu Asp Tyr Ala Ile
225                 230                 235                 240 
Ser His His Leu Thr Lys Ile Gln Gln Gln Ile Leu Glu His Lys Lys
                245                 250                 255     
Lys Ile Leu Lys Lys Glu Lys Ser Asp Val Gly Ser Ser Asp Glu Ser
            260                 265                 270         
Ala Val Ser Ile Phe His Glu Leu Arg Val Asp Ser Leu Pro Ala Ser
        275                 280                 285             
Asp Asp Lys Asp Leu Asn Val Ala Thr Lys Gln Cys Val Pro Glu Lys
    290                 295                 300                 
Val Ser Glu Pro Leu Pro Gly Ser Ser His Glu Lys Gly Asn Arg Ile
305                 310                 315                 320 
Val Asn Gly Gln Gly Glu Gly Pro Pro Ala Lys His Pro Ser Leu Lys
                325                 330                 335     
Pro Ser Thr Glu Val Glu Asp Pro Ala Val Lys Gly Ala Val Gln Arg
            340                 345                 350         
Lys Asn Val Gln Thr Leu Arg Ala Glu Gln Ala Leu Pro Val Ala Ser
        355                 360                 365             
Glu Glu Glu Gln Glu Arg His Glu Arg Ser Glu Lys Lys Gln Pro Gln
    370                 375                 380                 
Val Lys Glu Gly Asn Asn Thr Asn Lys Ser Glu Lys Ile Gln Leu Ser
385                 390                 395                 400 
Glu Asn Ile Cys Asp Ser Thr Ser Ser Ala Ala Ala Gly Arg Leu Thr
                405                 410                 415     
Gln Gln Arg Lys Ile Gly Lys Thr Tyr Pro Gln Gln Phe Pro Lys Lys
            420                 425                 430         
Leu Lys Glu Glu His Asp Arg Cys Thr Leu Lys Gln Glu Asn Glu Glu
        435                 440                 445             
Lys Thr Asn Val Asn Met Leu Tyr Lys Lys Asn Arg Glu Glu Leu Glu
    450                 455                 460                 
Arg Lys Glu Lys Gln Tyr Lys Lys Glu Val Glu Ala Lys Gln Leu Glu
465                 470                 475                 480 
Pro Thr Val Gln Ser Leu Glu Met Lys Ser Lys Thr Ala Arg Asn Thr
                485                 490                 495     
Pro Asn Arg Asp Phe His Asn His Glu Glu Met Lys Gly Leu Met Asp
            500                 505                 510         
Glu Asn Cys Ile Leu Lys Ala Asp Ile Ala Ile Leu Arg Gln Glu Ile
        515                 520                 525             
Cys Thr Met Lys Asn Asp Asn Leu Glu Lys Glu Asn Lys Tyr Leu Lys
    530                 535                 540                 
Asp Ile Lys Ile Val Lys Glu Thr Asn Ala Ala Leu Glu Lys Tyr Ile
545                 550                 555                 560 
Lys Leu Asn Glu Glu Met Ile Thr Glu Thr Ala Phe Arg Tyr Gln Gln
                565                 570                 575     
Glu Leu Asn Asp Leu Lys Ala Glu Asn Thr Arg Leu Asn Ala Glu Leu
            580                 585                 590         
Leu Lys Glu Lys Glu Ser Lys Lys Arg Leu Glu Ala Asp Ile Glu Ser
        595                 600                 605             
Tyr Gln Ser Arg Leu Ala Ala Ala Ile Ser Lys His Ser Glu Ser Val
    610                 615                 620                 
Lys Thr Glu Arg Asn Leu Lys Leu Ala Leu Glu Arg Thr Arg Asp Val
625                 630                 635                 640 
Ser Val Gln Val Glu Met Ser Ser Ala Ile Ser Lys Val Lys Ala Glu
                645                 650                 655     
Asn Glu Phe Leu Thr Glu Gln Leu Ser Glu Thr Gln Ile Lys Phe Asn
            660                 665                 670         
Ala Leu Lys Asp Lys Phe Cys Lys Thr Arg Asp Ser Leu Arg Lys Lys
        675                 680                 685             
Ser Leu Ala Leu Glu Thr Val Gln Asn Asp Leu Ser Gln Thr Gln Gln
    690                 695                 700                 
Gln Thr Gln Glu Met Lys Glu Met Tyr Gln Asn Ala Glu Ala Lys Val
705                 710                 715                 720 
Asn Asn Ser Thr Gly Lys Trp Asn Cys Val Glu Glu Arg Ile Cys His
                725                 730                 735     
Leu Gln Arg Glu Asn Ala Trp Leu Val Gln Gln Leu Asp Asp Val His
            740                 745                 750         
Gln Lys Glu Asp His Lys Glu Ile Val Thr Asn Ile Gln Arg Gly Phe
        755                 760                 765             
Ile Glu Ser Glu Lys Lys Asp Leu Val Leu Glu Glu Lys Ser Lys Lys
    770                 775                 780                 
Leu Met Asn Glu Cys Asp His Leu Lys Glu Ser Leu Phe Gln Tyr Glu
785                 790                 795                 800 
Arg Glu Lys Thr Gly Gly Val Val Ser Ile Lys Glu Asp Lys Tyr Phe
                805                 810                 815     
Gln Thr Ser Arg Lys Thr Ile
            820             


<210> 1825
<211> 939
<212> PRT
<213> Homo sapiens

<400> 1825
Met Glu Glu Ser Glu Asp Ser Gln Ser Asp Ser Gln Thr Arg Ile Ser
 1               5                  10                  15      
Glu Ser Gln His Ser Leu Lys Pro Asn Tyr Leu Ser Gln Ala Lys Thr
            20                  25                  30          
Asp Phe Ser Glu Gln Phe Gln Leu Leu Glu Asp Leu Gln Leu Lys Ile
        35                  40                  45              
Ala Ala Lys Leu Leu Arg Ser Gln Ile Pro Pro Asp Val Pro Pro Pro
    50                  55                  60                  
Leu Ala Ser Gly Leu Val Leu Lys Tyr Pro Ile Cys Leu Gln Cys Gly
65                  70                  75                  80  
Arg Cys Ser Gly Leu Asn Cys His His Lys Leu Gln Thr Thr Ser Gly
                85                  90                  95      
Pro Tyr Leu Leu Ile Tyr Pro Gln Leu His Leu Val Arg Thr Pro Glu
            100                 105                 110         
Gly His Gly Glu Val Arg Leu His Leu Gly Phe Arg Leu Arg Ile Gly
        115                 120                 125             
Lys Arg Ser Gln Ile Ser Lys Tyr Arg Glu Arg Asp Arg Pro Val Ile
    130                 135                 140                 
Arg Arg Ser Pro Ile Ser Pro Ser Gln Arg Lys Ala Lys Ile Tyr Thr
145                 150                 155                 160 
Gln Ala Ser Lys Ser Pro Thr Ser Thr Ile Asp Leu Gln Ser Gly Pro
                165                 170                 175     
Ser Gln Ser Pro Ala Pro Val Gln Val Tyr Ile Arg Arg Gly Gln Arg
            180                 185                 190         
Ser Arg Pro Asp Leu Val Glu Lys Thr Lys Thr Arg Ala Pro Gly His
        195                 200                 205             
Tyr Glu Phe Thr Gln Val His Asn Leu Pro Glu Ser Asp Ser Glu Ser
    210                 215                 220                 
Thr Gln Asn Glu Lys Arg Ala Lys Val Arg Thr Lys Lys Thr Ser Asp
225                 230                 235                 240 
Ser Lys Tyr Pro Met Lys Arg Ile Thr Lys Arg Leu Arg Lys His Arg
                245                 250                 255     
Lys Phe Tyr Thr Asn Ser Arg Thr Thr Ile Glu Ser Pro Ser Arg Glu
            260                 265                 270         
Leu Ala Ala His Leu Arg Arg Lys Arg Ile Gly Ala Thr Gln Thr Ser
        275                 280                 285             
Thr Ala Ser Leu Lys Arg Gln Pro Lys Lys Pro Ser Gln Pro Lys Phe
    290                 295                 300                 
Met Gln Leu Leu Phe Gln Ser Leu Lys Arg Ala Phe Gln Thr Ala His
305                 310                 315                 320 
Arg Val Ile Ala Ser Val Gly Arg Lys Pro Val Asp Gly Thr Arg Pro
                325                 330                 335     
Asp Asn Leu Trp Ala Ser Lys Asn Tyr Tyr Pro Lys Gln Asn Ala Arg
            340                 345                 350         
Asp Tyr Cys Leu Pro Ser Ser Ile Lys Arg Asp Lys Arg Ser Ala Asp
        355                 360                 365             
Lys Leu Thr Pro Ala Gly Ser Thr Ile Lys Gln Glu Asp Ile Leu Trp
    370                 375                 380                 
Gly Gly Thr Val Gln Cys Arg Ser Ala Gln Gln Pro Arg Arg Ala Tyr
385                 390                 395                 400 
Ser Phe Gln Pro Arg Pro Leu Arg Leu Pro Lys Pro Thr Asp Ser Gln
                405                 410                 415     
Ser Gly Ile Ala Phe Gln Thr Ala Ser Val Gly Gln Pro Leu Arg Thr
            420                 425                 430         
Val Gln Lys Asp Ser Ser Ser Arg Ser Lys Lys Asn Phe Tyr Arg Asn
        435                 440                 445             
Glu Thr Ser Ser Gln Glu Ser Lys Asn Leu Ser Thr Pro Gly Thr Arg
    450                 455                 460                 
Val Gln Ala Arg Gly Arg Ile Leu Pro Gly Ser Pro Val Lys Arg Thr
465                 470                 475                 480 
Trp His Arg His Leu Lys Asp Lys Leu Thr His Lys Glu His Asn His
                485                 490                 495     
Pro Ser Phe Tyr Arg Glu Arg Thr Pro Arg Gly Pro Ser Glu Arg Thr
            500                 505                 510         
Arg His Asn Pro Ser Trp Arg Asn His Arg Ser Pro Ser Glu Arg Ser
        515                 520                 525             
Gln Arg Ser Ser Leu Glu Arg Arg His His Ser Pro Ser Gln Arg Ser
    530                 535                 540                 
His Cys Ser Pro Ser Arg Lys Asn His Ser Ser Pro Ser Glu Arg Ser
545                 550                 555                 560 
Trp Arg Ser Pro Ser Gln Arg Asn His Cys Ser Pro Pro Glu Arg Ser
                565                 570                 575     
Cys His Ser Leu Ser Glu Arg Gly Leu His Ser Pro Ser Gln Arg Ser
            580                 585                 590         
His Arg Gly Pro Ser Gln Arg Arg His His Ser Pro Ser Glu Arg Ser
        595                 600                 605             
His Arg Ser Pro Ser Glu Arg Ser His Arg Ser Pro Ser Glu Arg Arg
    610                 615                 620                 
His Arg Ser Pro Ser Gln Arg Ser His Arg Gly Pro Ser Glu Arg Ser
625                 630                 635                 640 
His Cys Ser Pro Ser Glu Arg Arg His Arg Ser Pro Ser Gln Arg Ser
                645                 650                 655     
His Arg Gly Pro Ser Glu Arg Arg His His Ser Pro Ser Lys Arg Ser
            660                 665                 670         
His Arg Ser Pro Ala Arg Arg Ser His Arg Ser Pro Ser Glu Arg Ser
        675                 680                 685             
His His Ser Pro Ser Glu Arg Ser His His Ser Pro Ser Glu Arg Arg
    690                 695                 700                 
His His Ser Pro Ser Glu Arg Ser His Cys Ser Pro Ser Glu Arg Ser
705                 710                 715                 720 
His Cys Ser Pro Ser Glu Arg Arg His Arg Ser Pro Ser Glu Arg Arg
                725                 730                 735     
His His Ser Pro Ser Glu Lys Ser His His Ser Pro Ser Glu Arg Ser
            740                 745                 750         
His His Ser Pro Ser Glu Arg Arg Arg His Ser Pro Leu Glu Arg Ser
        755                 760                 765             
Arg His Ser Leu Leu Glu Arg Ser His Arg Ser Pro Ser Glu Arg Arg
    770                 775                 780                 
Ser His Arg Ser Phe Glu Arg Ser His Arg Arg Ile Ser Glu Arg Ser
785                 790                 795                 800 
His Ser Pro Ser Glu Lys Ser His Leu Ser Pro Leu Glu Arg Ser Arg
                805                 810                 815     
Cys Ser Pro Ser Glu Arg Arg Gly His Ser Ser Ser Gly Lys Thr Cys
            820                 825                 830         
His Ser Pro Ser Glu Arg Ser His Arg Ser Pro Ser Gly Met Arg Gln
        835                 840                 845             
Gly Arg Thr Ser Glu Arg Ser His Arg Ser Ser Cys Glu Arg Thr Arg
    850                 855                 860                 
His Ser Pro Ser Glu Met Arg Pro Gly Arg Pro Ser Gly Arg Asn His
865                 870                 875                 880 
Cys Ser Pro Ser Glu Arg Ser Arg Arg Ser Pro Leu Lys Glu Gly Leu
                885                 890                 895     
Lys Tyr Ser Phe Pro Gly Glu Arg Pro Ser His Ser Leu Ser Arg Asp
            900                 905                 910         
Phe Lys Asn Gln Thr Thr Leu Leu Gly Thr Thr His Lys Asn Pro Lys
        915                 920                 925             
Ala Gly Gln Val Trp Arg Pro Glu Ala Thr Arg
    930                 935                 


<210> 1826
<211> 195
<212> PRT
<213> Homo sapiens

<400> 1826
Met Glu Asn His Lys Ser Asn Asn Lys Glu Asn Ile Thr Ile Val Asp
 1               5                  10                  15      
Ile Ser Arg Lys Ile Asn Gln Leu Pro Glu Ala Glu Arg Asn Leu Leu
            20                  25                  30          
Glu Asn Gly Ser Val Tyr Val Gly Leu Asn Ala Ala Leu Cys Gly Leu
        35                  40                  45              
Ile Ala Asn Ser Leu Phe Arg Arg Ile Leu Asn Val Thr Lys Ala Arg
    50                  55                  60                  
Ile Ala Ala Gly Leu Pro Met Ala Gly Ile Pro Phe Leu Thr Thr Asp
65                  70                  75                  80  
Leu Thr Tyr Arg Cys Phe Val Ser Phe Pro Leu Asn Thr Gly Asp Leu
                85                  90                  95      
Asp Cys Glu Thr Cys Thr Ile Thr Arg Ser Gly Leu Thr Gly Leu Val
            100                 105                 110         
Ile Gly Gly Leu Tyr Pro Val Phe Leu Ala Ile Pro Val Asn Gly Gly
        115                 120                 125             
Leu Ala Ala Arg Tyr Gln Ser Ala Leu Leu Pro His Lys Gly Asn Ile
    130                 135                 140                 
Leu Ser Tyr Trp Ile Arg Thr Ser Lys Pro Val Phe Arg Lys Met Leu
145                 150                 155                 160 
Phe Pro Ile Leu Leu Gln Thr Met Phe Ser Ala Tyr Leu Gly Ser Glu
                165                 170                 175     
Gln Tyr Lys Leu Leu Ile Lys Ala Leu Gln Leu Ser Glu Pro Gly Lys
            180                 185                 190         
Glu Ile His
        195 


<210> 1827
<211> 828
<212> PRT
<213> Homo sapiens

<400> 1827
Met Met Glu Gly Leu Lys Lys Arg Thr Arg Lys Ala Phe Gly Ile Arg
 1               5                  10                  15      
Lys Lys Glu Lys Asp Thr Asp Ser Thr Gly Ser Pro Asp Arg Asp Gly
            20                  25                  30          
Ile Gln Pro Ser Pro His Glu Pro Pro Tyr Asn Ser Lys Ala Glu Cys
        35                  40                  45              
Ala Arg Glu Gly Gly Lys Lys Val Ser Lys Lys Ser Asn Gly Ala Pro
    50                  55                  60                  
Asn Gly Phe Tyr Ala Glu Ile Asp Trp Glu Arg Tyr Asn Ser Pro Glu
65                  70                  75                  80  
Leu Asp Glu Glu Gly Tyr Ser Ile Arg Pro Glu Glu Pro Gly Ser Thr
                85                  90                  95      
Lys Gly Lys His Phe Tyr Ser Ser Ser Glu Ser Glu Glu Glu Glu Glu
            100                 105                 110         
Ser His Lys Lys Phe Asn Ile Lys Ile Lys Pro Leu Gln Ser Lys Asp
        115                 120                 125             
Ile Leu Arg Asn Ala Ala Thr Val Asp Glu Leu Lys Ala Ser Ile Gly
    130                 135                 140                 
Asn Ile Ala Leu Ser Pro Ser Pro Val Arg Lys Ser Pro Arg Arg Ser
145                 150                 155                 160 
Pro Gly Ala Ile Lys Arg Asn Leu Ser Ser Glu Glu Val Ala Arg Pro
                165                 170                 175     
Arg Arg Ser Thr Pro Thr Pro Glu Leu Ile Ser Lys Lys Pro Pro Asp
            180                 185                 190         
Asp Thr Thr Ala Leu Ala Pro Leu Phe Gly Pro Pro Leu Glu Ser Ala
        195                 200                 205             
Phe Asp Glu Gln Lys Thr Glu Val Leu Leu Asp Gln Pro Glu Ile Trp
    210                 215                 220                 
Gly Ser Gly Gln Pro Ile Asn Pro Ser Met Glu Ser Pro Lys Leu Thr
225                 230                 235                 240 
Arg Pro Phe Pro Thr Gly Thr Pro Pro Pro Leu Pro Pro Lys Asn Val
                245                 250                 255     
Pro Ala Thr Pro Pro Arg Thr Gly Ser Pro Leu Thr Ile Gly Pro Gly
            260                 265                 270         
Asn Asp Gln Ser Ala Thr Glu Val Lys Ile Glu Lys Leu Pro Ser Ile
        275                 280                 285             
Asn Asp Leu Asp Ser Ile Phe Gly Pro Val Leu Ser Pro Lys Ser Val
    290                 295                 300                 
Ala Val Asn Ala Glu Glu Lys Trp Val His Phe Ser Asp Thr Ser Pro
305                 310                 315                 320 
Glu His Val Thr Pro Glu Leu Thr Pro Arg Glu Lys Val Val Ser Pro
                325                 330                 335     
Pro Ala Thr Pro Asp Asn Pro Ala Asp Ser Pro Ala Pro Gly Pro Leu
            340                 345                 350         
Gly Pro Pro Gly Pro Thr Gly Pro Pro Gly Pro Pro Gly Pro Pro Arg
        355                 360                 365             
Asn Val Leu Ser Pro Leu Asn Leu Glu Glu Val Gln Lys Lys Val Ala
    370                 375                 380                 
Glu Gln Thr Phe Ile Lys Asp Asp Tyr Leu Glu Thr Ile Ser Ser Pro
385                 390                 395                 400 
Lys Asp Phe Gly Leu Gly Gln Arg Ala Thr Pro Pro Pro Pro Pro Pro
                405                 410                 415     
Pro Thr Tyr Arg Thr Val Val Ser Ser Pro Gly Pro Gly Ser Gly Pro
            420                 425                 430         
Gly Pro Gly Thr Thr Ser Gly Ala Ser Ser Pro Ala Arg Pro Ala Thr
        435                 440                 445             
Pro Leu Val Pro Cys Arg Ser Thr Thr Pro Pro Pro Pro Pro Pro Arg
    450                 455                 460                 
Pro Pro Ser Arg Pro Lys Leu Pro Pro Gly Lys Pro Gly Val Gly Asp
465                 470                 475                 480 
Val Ser Arg Pro Phe Ser Pro Pro Ile His Ser Ser Ser Pro Pro Pro
                485                 490                 495     
Ile Ala Pro Leu Ala Arg Ala Glu Ser Thr Ser Ser Ile Ser Ser Thr
            500                 505                 510         
Asn Ser Leu Ser Ala Ala Thr Thr Pro Thr Val Glu Asn Glu Gln Pro
        515                 520                 525             
Ser Leu Val Trp Phe Asp Arg Gly Lys Phe Tyr Leu Thr Phe Glu Gly
    530                 535                 540                 
Ser Ser Arg Gly Pro Ser Pro Leu Thr Met Gly Ala Gln Asp Thr Leu
545                 550                 555                 560 
Pro Val Ala Ala Ala Phe Thr Glu Thr Val Asn Ala Tyr Phe Lys Gly
                565                 570                 575     
Ala Asp Pro Ser Lys Cys Ile Val Lys Ile Thr Gly Glu Met Val Leu
            580                 585                 590         
Ser Phe Pro Ala Gly Ile Thr Arg His Phe Ala Asn Asn Pro Ser Pro
        595                 600                 605             
Ala Ala Leu Thr Phe Arg Val Ile Asn Phe Ser Arg Leu Glu His Val
    610                 615                 620                 
Leu Pro Asn Pro Gln Leu Leu Cys Cys Asp Asn Thr Gln Asn Asp Ala
625                 630                 635                 640 
Asn Thr Lys Glu Phe Trp Val Asn Met Pro Asn Leu Met Thr His Leu
                645                 650                 655     
Lys Lys Val Ser Glu Gln Lys Pro Gln Ala Thr Tyr Tyr Asn Val Asp
            660                 665                 670         
Met Leu Lys Tyr Gln Val Ser Ala Gln Gly Ile Gln Ser Thr Pro Leu
        675                 680                 685             
Asn Leu Ala Val Asn Trp Arg Cys Glu Pro Ser Ser Thr Asp Leu Arg
    690                 695                 700                 
Ile Asp Tyr Lys Tyr Asn Thr Asp Ala Met Thr Thr Ala Val Ala Leu
705                 710                 715                 720 
Asn Asn Val Gln Phe Leu Val Pro Ile Asp Gly Gly Val Thr Lys Leu
                725                 730                 735     
Gln Ala Val Leu Pro Pro Ala Val Trp Asn Ala Glu Gln Gln Arg Ile
            740                 745                 750         
Leu Trp Lys Ile Pro Asp Ile Ser Gln Lys Ser Glu Asn Gly Gly Val
        755                 760                 765             
Gly Ser Leu Leu Ala Arg Phe Gln Leu Ser Glu Gly Pro Ser Lys Pro
    770                 775                 780                 
Ser Pro Leu Val Val Gln Phe Thr Ser Glu Gly Ser Thr Leu Ser Gly
785                 790                 795                 800 
Cys Asp Ile Glu Leu Val Gly Ala Gly Tyr Arg Phe Ser Leu Ile Lys
                805                 810                 815     
Lys Arg Phe Ala Ala Gly Lys Tyr Leu Ala Asp Asn
            820                 825             


<210> 1828
<211> 345
<212> PRT
<213> Homo sapiens

<400> 1828
Met Leu Pro Asn Thr Gly Arg Leu Ala Gly Cys Thr Val Phe Ile Thr
 1               5                  10                  15      
Gly Ala Ser Arg Gly Ile Gly Lys Ala Ile Ala Leu Lys Ala Ala Lys
            20                  25                  30          
Asp Gly Ala Asn Ile Val Ile Ala Ala Lys Thr Ala Gln Pro His Pro
        35                  40                  45              
Lys Leu Leu Gly Thr Ile Tyr Thr Ala Ala Glu Glu Ile Glu Ala Val
    50                  55                  60                  
Gly Gly Lys Ala Leu Pro Cys Ile Val Asp Val Arg Asp Glu Gln Gln
65                  70                  75                  80  
Ile Ser Ala Ala Val Glu Lys Ala Ile Lys Lys Phe Gly Ala Tyr Thr
                85                  90                  95      
Ile Ala Lys Tyr Gly Met Ser Met Tyr Val Leu Gly Met Ala Glu Glu
            100                 105                 110         
Phe Lys Gly Glu Ile Ala Val Asn Ala Leu Trp Pro Lys Thr Ala Ile
        115                 120                 125             
His Thr Ala Ala Met Asp Met Leu Gly Gly Pro Gly Ile Glu Ser Gln
    130                 135                 140                 
Cys Arg Lys Val Asp Ile Ile Ala Asp Ala Ala Tyr Ser Ile Phe Gln
145                 150                 155                 160 
Lys Pro Lys Ser Phe Thr Gly Asn Phe Val Ile Asp Glu Asn Ile Leu
                165                 170                 175     
Lys Glu Glu Gly Ile Glu Asn Phe Asp Val Tyr Ala Ile Lys Pro Gly
            180                 185                 190         
His Pro Leu Gln Pro Asp Phe Phe Leu Asp Glu Tyr Pro Glu Ala Val
        195                 200                 205             
Ser Lys Lys Val Glu Ser Thr Gly Ala Val Pro Glu Phe Lys Glu Glu
    210                 215                 220                 
Lys Leu Gln Leu Gln Pro Lys Pro Arg Ser Gly Ala Val Glu Glu Thr
225                 230                 235                 240 
Phe Arg Ile Val Lys Asp Ser Leu Ser Asp Asp Val Val Lys Ala Thr
                245                 250                 255     
Gln Ala Ile Tyr Leu Phe Glu Leu Ser Gly Glu Asp Gly Gly Thr Trp
            260                 265                 270         
Phe Leu Asp Leu Lys Ser Lys Gly Gly Asn Val Gly Tyr Gly Glu Pro
        275                 280                 285             
Ser Asp Gln Ala Asp Val Val Met Ser Met Thr Thr Asp Asp Phe Val
    290                 295                 300                 
Lys Met Phe Ser Gly Lys Leu Lys Pro Thr Met Ala Phe Met Ser Gly
305                 310                 315                 320 
Lys Leu Lys Ile Lys Gly Asn Met Ala Leu Ala Ile Lys Leu Glu Lys
                325                 330                 335     
Leu Met Asn Gln Met Asn Ala Arg Leu
            340                 345 


<210> 1829
<211> 183
<212> PRT
<213> Homo sapiens

<400> 1829
Met Thr Asp Gln Thr Tyr Cys Asp Arg Leu Val Gln Asp Thr Pro Phe
 1               5                  10                  15      
Leu Thr Gly His Gly Arg Leu Ser Glu Gln Gln Val Asp Arg Ile Ile
            20                  25                  30          
Leu Gln Leu Asn Arg Tyr Tyr Pro Gln Ile Leu Thr Asn Lys Glu Ala
        35                  40                  45              
Glu Lys Phe Arg Asn Pro Lys Ala Ser Leu Arg Val Arg Leu Cys Asp
    50                  55                  60                  
Leu Leu Ser His Leu Gln Arg Ser Gly Glu Arg Asp Cys Gln Glu Phe
65                  70                  75                  80  
Tyr Arg Ala Leu Tyr Ile His Ala Gln Pro Leu His Ser Arg Leu Pro
                85                  90                  95      
Ser Arg His Ala Leu Gln Asn Ser Asp Cys Thr Glu Leu Asp Ser Gly
            100                 105                 110         
Ser Gln Ser Gly Glu Leu Ser Asn Arg Gly Pro Met Ser Phe Leu Ala
        115                 120                 125             
Gly Leu Gly Leu Ala Val Gly Leu Ala Leu Leu Leu Tyr Cys Tyr Pro
    130                 135                 140                 
Pro Asp Pro Lys Gly Leu Pro Gly Thr Arg Arg Val Leu Gly Phe Ser
145                 150                 155                 160 
Pro Val Ile Ile Asp Arg His Val Ser Arg Tyr Leu Leu Ala Phe Leu
                165                 170                 175     
Ala Asp Asp Leu Gly Gly Leu
            180             


<210> 1830
<211> 183
<212> PRT
<213> Homo sapiens

<400> 1830
Met Thr Asp Gln Thr Tyr Cys Asp Arg Leu Val Gln Asp Thr Pro Phe
 1               5                  10                  15      
Leu Thr Gly His Gly Arg Leu Ser Glu Gln Gln Val Asp Arg Ile Ile
            20                  25                  30          
Leu Gln Leu Asn Arg Tyr Tyr Pro Gln Ile Leu Thr Asn Lys Glu Ala
        35                  40                  45              
Glu Lys Phe Arg Asn Pro Lys Ala Ser Leu Arg Val Arg Leu Cys Asp
    50                  55                  60                  
Leu Leu Ser His Leu Gln Arg Ser Gly Glu Arg Asp Cys Gln Glu Phe
65                  70                  75                  80  
Tyr Arg Ala Leu Tyr Ile His Ala Gln Pro Leu His Ser Arg Leu Pro
                85                  90                  95      
Ser Arg His Ala Leu Gln Asn Ser Asp Cys Thr Glu Leu Asp Ser Gly
            100                 105                 110         
Ser Gln Ser Gly Glu Leu Ser Asn Arg Gly Pro Met Ser Phe Leu Ala
        115                 120                 125             
Gly Leu Gly Leu Ala Val Gly Leu Ala Leu Leu Leu Tyr Cys Tyr Pro
    130                 135                 140                 
Pro Asp Pro Lys Gly Leu Pro Gly Thr Arg Arg Val Leu Gly Phe Ser
145                 150                 155                 160 
Pro Val Ile Ile Asp Arg His Val Ser Arg Tyr Leu Leu Ala Phe Leu
                165                 170                 175     
Ala Asp Asp Leu Gly Gly Leu
            180             


<210> 1831
<211> 307
<212> PRT
<213> Homo sapiens

<400> 1831
Met Arg Gly Cys Gln Leu Leu Gly Leu Arg Ser Ser Trp Pro Gly Asp
 1               5                  10                  15      
Leu Leu Ser Ala Arg Leu Leu Ser Gln Glu Lys Arg Ala Ala Glu Thr
            20                  25                  30          
His Phe Gly Phe Glu Thr Val Ser Glu Glu Glu Lys Gly Gly Lys Val
        35                  40                  45              
Tyr Gln Val Phe Glu Ser Val Ala Lys Lys Tyr Asp Val Met Asn Asp
    50                  55                  60                  
Met Met Ser Leu Gly Ile His Arg Val Trp Lys Asp Leu Leu Leu Trp
65                  70                  75                  80  
Lys Met His Pro Leu Pro Gly Thr Gln Leu Leu Asp Val Ala Gly Gly
                85                  90                  95      
Thr Gly Asp Ile Ala Phe Arg Phe Leu Asn Tyr Val Gln Ser Gln His
            100                 105                 110         
Gln Arg Lys Gln Lys Arg Gln Leu Arg Ala Gln Gln Asn Leu Ser Trp
        115                 120                 125             
Glu Glu Ile Thr Lys Glu Tyr Gln Asn Glu Glu Asp Ser Leu Gly Gly
    130                 135                 140                 
Ser Arg Val Val Val Cys Asp Ile Asn Lys Glu Met Leu Lys Val Gly
145                 150                 155                 160 
Lys Gln Lys Ala Leu Ala Gln Gly Tyr Arg Ala Gly Leu Ala Trp Val
                165                 170                 175     
Leu Gly Asp Ala Glu Glu Leu Pro Phe Asp Asp Asp Lys Phe Asp Ile
            180                 185                 190         
Tyr Thr Ile Ala Phe Gly Ile Arg Asn Val Thr His Ile Asp Gln Ala
        195                 200                 205             
Leu Gln Glu Ala His Arg Val Leu Lys Pro Gly Gly Arg Phe Leu Cys
    210                 215                 220                 
Leu Glu Phe Ser Gln Val Asn Asn Pro Leu Ile Ser Arg Leu Tyr Asp
225                 230                 235                 240 
Leu Tyr Ser Phe Gln Val Ile Pro Val Leu Gly Glu Val Ile Ala Gly
                245                 250                 255     
Asp Trp Lys Ser Tyr Gln Tyr Leu Val Glu Ser Ile Arg Arg Ser Pro
            260                 265                 270         
Ser Gln Glu Glu Phe Lys Asp Met Ile Glu Asp Ala Gly Phe His Lys
        275                 280                 285             
Val Thr Tyr Glu Ser Leu Thr Ser Gly Ile Val Ala Ile His Ser Gly
    290                 295                 300                 
Phe Lys Leu
305         


<210> 1832
<211> 216
<212> PRT
<213> Homo sapiens

<400> 1832
Met Trp Ser Ile Gly Ala Gly Ala Leu Gly Ala Ala Ala Leu Ala Leu
 1               5                  10                  15      
Leu Leu Ala Asn Thr Asp Val Phe Leu Ser Lys Pro Gln Lys Ala Ala
            20                  25                  30          
Leu Glu Tyr Leu Glu Asp Ile Asp Leu Lys Thr Leu Glu Lys Glu Pro
        35                  40                  45              
Arg Thr Phe Lys Ala Lys Glu Leu Trp Glu Lys Asn Gly Ala Val Ile
    50                  55                  60                  
Met Ala Val Arg Arg Pro Gly Cys Phe Leu Cys Arg Glu Glu Ala Ala
65                  70                  75                  80  
Asp Leu Ser Ser Leu Lys Ser Met Leu Asp Gln Leu Gly Val Pro Leu
                85                  90                  95      
Tyr Ala Val Val Lys Glu His Ile Arg Thr Glu Val Lys Asp Phe Gln
            100                 105                 110         
Pro Tyr Phe Lys Gly Glu Ile Phe Leu Asp Glu Lys Lys Lys Phe Tyr
        115                 120                 125             
Gly Pro Gln Arg Arg Lys Met Met Phe Met Gly Phe Ile Arg Leu Gly
    130                 135                 140                 
Val Trp Tyr Asn Phe Phe Arg Ala Trp Asn Gly Gly Phe Ser Gly Asn
145                 150                 155                 160 
Leu Glu Gly Glu Gly Phe Ile Leu Gly Gly Val Phe Val Val Gly Ser
                165                 170                 175     
Gly Lys Gln Gly Ile Leu Leu Glu His Arg Glu Lys Glu Phe Gly Asp
            180                 185                 190         
Lys Val Asn Leu Leu Ser Val Leu Glu Ala Ala Lys Met Ile Lys Pro
        195                 200                 205             
Gln Thr Leu Ala Ser Glu Lys Lys
    210                 215     


<210> 1833
<211> 126
<212> PRT
<213> Homo sapiens

<400> 1833
Met Ala Ala Ser Arg Tyr Arg Arg Phe Leu Lys Leu Cys Glu Glu Trp
 1               5                  10                  15      
Pro Val Asp Glu Thr Lys Arg Gly Arg Asp Leu Gly Ala Tyr Leu Arg
            20                  25                  30          
Gln Arg Val Ala Gln Ala Phe Arg Glu Gly Glu Asn Thr Gln Val Ala
        35                  40                  45              
Glu Pro Glu Ala Cys Asp Gln Met Tyr Glu Ser Leu Ala Arg Leu His
    50                  55                  60                  
Ser Asn Tyr Tyr Lys His Lys Tyr Pro Arg Pro Arg Asp Thr Ser Phe
65                  70                  75                  80  
Ser Gly Leu Ser Leu Glu Glu Tyr Lys Leu Ile Leu Ser Thr Asp Thr
                85                  90                  95      
Leu Glu Glu Leu Lys Glu Ile Asp Lys Gly Met Trp Lys Lys Leu Gln
            100                 105                 110         
Glu Lys Phe Ala Pro Lys Gly Pro Glu Glu Asp His Lys Ala
        115                 120                 125     


<210> 1834
<211> 235
<212> PRT
<213> Homo sapiens

<400> 1834
Met Gly Ser Thr Glu Ser Ser Glu Gly Arg Arg Val Ser Phe Gly Val
 1               5                  10                  15      
Asp Glu Glu Glu Arg Val Arg Val Leu Gln Gly Val Arg Leu Ser Glu
            20                  25                  30          
Asn Val Val Asn Arg Met Lys Glu Pro Ser Ser Pro Pro Pro Ala Pro
        35                  40                  45              
Thr Ser Ser Thr Phe Gly Leu Gln Asp Gly Asn Leu Arg Ala Pro His
    50                  55                  60                  
Lys Glu Ser Thr Leu Pro Arg Ser Gly Ser Ser Gly Gly Gln Gln Pro
65                  70                  75                  80  
Ser Gly Met Lys Glu Gly Val Lys Arg Tyr Glu Gln Glu His Ala Ala
                85                  90                  95      
Ile Gln Asp Lys Leu Phe Gln Val Ala Lys Arg Glu Arg Glu Ala Ala
            100                 105                 110         
Thr Lys His Ser Lys Ala Ser Leu Pro Thr Gly Glu Gly Ser Ile Ser
        115                 120                 125             
His Glu Glu Gln Lys Ser Val Arg Leu Ala Arg Glu Leu Glu Ser Arg
    130                 135                 140                 
Glu Ala Glu Leu Arg Arg Arg Asp Thr Phe Tyr Lys Glu Gln Leu Glu
145                 150                 155                 160 
Arg Ile Glu Arg Lys Asn Ala Glu Met Tyr Lys Leu Ser Ser Glu Gln
                165                 170                 175     
Phe His Glu Ala Ala Ser Lys Met Glu Ser Thr Ile Lys Pro Arg Arg
            180                 185                 190         
Val Glu Pro Val Cys Ser Gly Leu Gln Ala Gln Ile Leu His Cys Tyr
        195                 200                 205             
Arg Asp Arg Pro His Glu Val Leu Leu Cys Ser Asp Leu Val Lys Ala
    210                 215                 220                 
Tyr Gln Arg Cys Val Ser Ala Ala His Lys Gly
225                 230                 235 


<210> 1835
<211> 176
<212> PRT
<213> Homo sapiens

<400> 1835
Met Ala Met Ser Phe Glu Trp Pro Trp Gln Tyr Arg Phe Pro Pro Phe
 1               5                  10                  15      
Phe Thr Leu Gln Pro Asn Val Asp Thr Arg Gln Lys Gln Leu Ala Ala
            20                  25                  30          
Trp Cys Ser Leu Val Leu Ser Phe Cys Arg Leu His Lys Gln Ser Ser
        35                  40                  45              
Met Thr Val Met Glu Ala Gln Glu Ser Pro Leu Phe Asn Asn Val Lys
    50                  55                  60                  
Leu Gln Arg Lys Leu Pro Val Glu Ser Ile Gln Ile Val Leu Glu Glu
65                  70                  75                  80  
Leu Arg Lys Lys Gly Asn Leu Glu Trp Leu Asp Lys Ser Lys Ser Ser
                85                  90                  95      
Phe Leu Ile Met Trp Arg Arg Pro Glu Glu Trp Gly Lys Leu Ile Tyr
            100                 105                 110         
Gln Trp Val Ser Arg Ser Gly Gln Asn Asn Ser Val Phe Thr Leu Tyr
        115                 120                 125             
Glu Leu Thr Asn Gly Glu Asp Thr Glu Asp Glu Glu Phe His Gly Leu
    130                 135                 140                 
Asp Glu Ala Thr Leu Leu Arg Ala Leu Gln Ala Leu Gln Gln Glu His
145                 150                 155                 160 
Lys Ala Glu Ile Ile Thr Val Ser Asp Gly Arg Gly Val Lys Phe Phe
                165                 170                 175     


<210> 1836
<211> 483
<212> PRT
<213> Homo sapiens

<400> 1836
Met Glu Glu Gly Gly Gly Gly Val Arg Ser Leu Val Pro Gly Gly Pro
 1               5                  10                  15      
Val Leu Leu Val Leu Cys Gly Leu Leu Glu Ala Ser Gly Gly Gly Arg
            20                  25                  30          
Ala Leu Pro Gln Leu Ser Asp Asp Ile Pro Phe Arg Val Asn Trp Pro
        35                  40                  45              
Gly Thr Glu Phe Ser Leu Pro Thr Thr Gly Val Leu Tyr Lys Glu Asp
    50                  55                  60                  
Asn Tyr Val Ile Met Thr Thr Ala His Lys Glu Lys Tyr Lys Cys Ile
65                  70                  75                  80  
Leu Pro Leu Val Thr Ser Gly Asp Glu Glu Glu Glu Lys Asp Tyr Lys
                85                  90                  95      
Gly Pro Asn Pro Arg Glu Leu Leu Glu Pro Leu Phe Lys Gln Ser Ser
            100                 105                 110         
Cys Ser Tyr Arg Ile Glu Ser Tyr Trp Thr Tyr Glu Val Cys His Gly
        115                 120                 125             
Lys His Ile Arg Gln Tyr His Glu Glu Lys Glu Thr Gly Gln Lys Ile
    130                 135                 140                 
Asn Ile His Glu Tyr Tyr Leu Gly Asn Met Leu Ala Lys Asn Leu Leu
145                 150                 155                 160 
Phe Glu Lys Glu Arg Glu Ala Glu Glu Lys Glu Lys Ser Asn Glu Ile
                165                 170                 175     
Pro Thr Lys Asn Ile Glu Gly Gln Met Thr Pro Tyr Tyr Pro Val Gly
            180                 185                 190         
Met Gly Asn Gly Thr Pro Cys Ser Leu Lys Gln Asn Arg Pro Arg Ser
        195                 200                 205             
Ser Thr Val Met Tyr Ile Cys His Pro Glu Ser Lys His Glu Ile Leu
    210                 215                 220                 
Ser Val Ala Glu Val Thr Thr Cys Glu Tyr Glu Val Val Ile Leu Thr
225                 230                 235                 240 
Pro Leu Leu Cys Ser His Pro Lys Tyr Arg Phe Arg Ala Ser Pro Val
                245                 250                 255     
Asn Asp Ile Phe Cys Gln Ser Leu Pro Gly Ser Pro Phe Lys Pro Leu
            260                 265                 270         
Thr Leu Arg Gln Leu Glu Gln Gln Glu Glu Ile Leu Arg Val Pro Phe
        275                 280                 285             
Arg Arg Asn Lys Glu Glu Asp Leu Gln Ser Thr Lys Glu Glu Arg Phe
    290                 295                 300                 
Pro Ala Ile His Lys Ser Ile Ala Ile Gly Ser Gln Pro Val Leu Thr
305                 310                 315                 320 
Val Gly Thr Thr His Ile Ser Lys Leu Thr Gly Asp Gln Leu Ile Lys
                325                 330                 335     
Glu Phe Leu Ser Gly Ser Tyr Cys Phe Arg Gly Gly Val Gly Trp Trp
            340                 345                 350         
Lys Tyr Glu Phe Cys Tyr Gly Lys His Val His Gln Tyr His Glu Asp
        355                 360                 365             
Lys Asp Ser Gly Lys Thr Ser Val Val Val Gly Thr Trp Asn Gln Glu
    370                 375                 380                 
Glu His Ile Glu Trp Ala Lys Glu Asn Thr Ala Arg Ala Tyr His Leu
385                 390                 395                 400 
Gln Asp Asp Gly Thr Gln Thr Val Arg Met Val Ser His Phe Tyr Gly
                405                 410                 415     
Asn Gly Asp Ile Cys Asp Ile Thr Asp Lys Pro Arg Gln Val Thr Val
            420                 425                 430         
Lys Leu Lys Cys Lys Glu Ser Asp Ser Pro His Ala Val Thr Val Tyr
        435                 440                 445             
Met Leu Glu Pro His Ser Cys Gln Tyr Ile Leu Gly Val Glu Ser Pro
    450                 455                 460                 
Val Ile Cys Lys Ile Leu Asp Thr Ala Asp Glu Asn Gly Leu Leu Ser
465                 470                 475                 480 
Leu Pro Asn
            


<210> 1837
<211> 178
<212> PRT
<213> Homo sapiens

<400> 1837
Met Ser Ser Phe Ser Arg Ala Pro Gln Gln Trp Ala Thr Phe Ala Arg
 1               5                  10                  15      
Ile Trp Tyr Leu Leu Asp Gly Lys Met Gln Pro Pro Gly Lys Leu Ala
            20                  25                  30          
Ala Met Ala Ser Ile Arg Leu Gln Gly Leu His Lys Pro Val Tyr His
        35                  40                  45              
Ala Leu Ser Asp Cys Gly Asp His Val Val Ile Met Asn Thr Arg His
    50                  55                  60                  
Ile Ala Phe Ser Gly Asn Lys Trp Glu Gln Lys Val Tyr Ser Ser His
65                  70                  75                  80  
Thr Gly Tyr Pro Gly Gly Phe Arg Gln Val Thr Ala Ala Gln Leu His
                85                  90                  95      
Leu Arg Asp Pro Val Ala Ile Val Lys Leu Ala Ile Tyr Gly Met Leu
            100                 105                 110         
Pro Lys Asn Leu His Arg Arg Thr Met Met Glu Arg Leu His Leu Phe
        115                 120                 125             
Pro Asp Glu Tyr Ile Pro Glu Asp Ile Leu Lys Asn Leu Val Glu Glu
    130                 135                 140                 
Leu Pro Gln Pro Arg Lys Ile Pro Lys Arg Leu Asp Glu Tyr Thr Gln
145                 150                 155                 160 
Glu Glu Ile Asp Ala Phe Pro Arg Leu Trp Thr Pro Pro Glu Asp Tyr
                165                 170                 175     
Arg Leu
        


<210> 1838
<211> 1140
<212> PRT
<213> Homo sapiens

<400> 1838
Met Val Ile Ser Leu Asn Ser Cys Leu Ser Phe Ile Cys Leu Leu Leu
 1               5                  10                  15      
Cys His Trp Ile Gly Thr Ala Ser Pro Leu Asn Leu Glu Asp Pro Asn
            20                  25                  30          
Val Cys Ser His Trp Glu Ser Tyr Ser Val Thr Val Gln Glu Ser Tyr
        35                  40                  45              
Pro His Pro Phe Asp Gln Ile Tyr Tyr Thr Ser Cys Thr Asp Ile Leu
    50                  55                  60                  
Asn Trp Phe Lys Cys Thr Arg His Arg Val Ser Tyr Arg Thr Ala Tyr
65                  70                  75                  80  
Arg His Gly Glu Lys Thr Met Tyr Arg Arg Lys Ser Gln Cys Cys Pro
                85                  90                  95      
Gly Phe Tyr Glu Ser Gly Glu Met Cys Val Pro His Cys Ala Asp Lys
            100                 105                 110         
Cys Val His Gly Arg Cys Ile Ala Pro Asn Thr Cys Gln Cys Glu Pro
        115                 120                 125             
Gly Trp Gly Gly Thr Asn Cys Ser Ser Ala Cys Asp Gly Asp His Trp
    130                 135                 140                 
Gly Pro His Cys Thr Ser Arg Cys Gln Cys Lys Asn Gly Ala Leu Cys
145                 150                 155                 160 
Asn Pro Ile Thr Gly Ala Cys His Cys Ala Ala Gly Phe Arg Gly Trp
                165                 170                 175     
Arg Cys Glu Asp Arg Cys Glu Gln Gly Thr Tyr Gly Asn Asp Cys His
            180                 185                 190         
Gln Arg Cys Gln Cys Gln Asn Gly Ala Thr Cys Asp His Val Thr Gly
        195                 200                 205             
Glu Cys Arg Cys Pro Pro Gly Tyr Thr Gly Ala Phe Cys Glu Asp Leu
    210                 215                 220                 
Cys Pro Pro Gly Lys His Gly Pro Gln Cys Glu Gln Arg Cys Pro Cys
225                 230                 235                 240 
Gln Asn Gly Gly Val Cys His His Val Thr Gly Glu Cys Ser Cys Pro
                245                 250                 255     
Ser Gly Trp Met Gly Thr Val Cys Gly Gln Pro Cys Pro Glu Gly Arg
            260                 265                 270         
Phe Gly Lys Asn Cys Ser Gln Glu Cys Gln Cys His Asn Gly Gly Thr
        275                 280                 285             
Cys Asp Ala Ala Thr Gly Gln Cys His Cys Ser Pro Gly Tyr Thr Gly
    290                 295                 300                 
Glu Arg Cys Gln Asp Glu Cys Pro Val Gly Thr Tyr Gly Val Leu Cys
305                 310                 315                 320 
Ala Glu Thr Cys Gln Cys Val Asn Gly Gly Lys Cys Tyr His Val Ser
                325                 330                 335     
Gly Ala Cys Leu Cys Glu Ala Gly Phe Ala Gly Glu Arg Cys Glu Ala
            340                 345                 350         
Arg Leu Cys Pro Glu Gly Leu Tyr Gly Ile Lys Cys Asp Lys Arg Cys
        355                 360                 365             
Pro Cys His Leu Glu Asn Thr His Ser Cys His Pro Met Ser Gly Glu
    370                 375                 380                 
Cys Ala Cys Lys Pro Gly Trp Ser Gly Leu Tyr Cys Asn Glu Thr Cys
385                 390                 395                 400 
Ser Pro Gly Phe Tyr Gly Glu Ala Cys Gln Gln Ile Cys Ser Cys Gln
                405                 410                 415     
Asn Gly Ala Asp Cys Asp Ser Val Thr Gly Lys Cys Thr Cys Ala Pro
            420                 425                 430         
Gly Phe Lys Gly Ile Asp Cys Ser Thr Pro Cys Pro Leu Gly Thr Tyr
        435                 440                 445             
Gly Ile Asn Cys Ser Ser Arg Cys Gly Cys Lys Asn Asp Ala Val Cys
    450                 455                 460                 
Ser Pro Val Asp Gly Ser Cys Thr Cys Lys Ala Gly Trp His Gly Val
465                 470                 475                 480 
Asp Cys Ser Ile Arg Cys Pro Ser Gly Thr Trp Gly Phe Gly Cys Asn
                485                 490                 495     
Leu Thr Cys Gln Cys Leu Asn Gly Gly Ala Cys Asn Thr Leu Asp Gly
            500                 505                 510         
Thr Cys Thr Cys Ala Pro Gly Trp Arg Gly Glu Lys Cys Glu Leu Pro
        515                 520                 525             
Cys Gln Asp Gly Thr Tyr Gly Leu Asn Cys Ala Glu Arg Cys Asp Cys
    530                 535                 540                 
Ser His Ala Asp Gly Cys His Pro Thr Thr Gly His Cys Arg Cys Leu
545                 550                 555                 560 
Pro Gly Trp Ser Gly Val His Cys Asp Ser Val Cys Ala Glu Gly Arg
                565                 570                 575     
Trp Gly Pro Asn Cys Ser Leu Pro Cys Tyr Cys Lys Asn Gly Ala Ser
            580                 585                 590         
Cys Ser Pro Asp Asp Gly Ile Cys Glu Cys Ala Pro Gly Phe Arg Gly
        595                 600                 605             
Thr Thr Cys Gln Arg Ile Cys Ser Pro Gly Phe Tyr Gly His Arg Cys
    610                 615                 620                 
Ser Gln Thr Cys Pro Gln Cys Val His Ser Ser Gly Pro Cys His His
625                 630                 635                 640 
Ile Thr Gly Leu Cys Asp Cys Leu Pro Gly Phe Thr Gly Ala Leu Cys
                645                 650                 655     
Asn Glu Val Cys Pro Ser Gly Arg Phe Gly Lys Asn Cys Ala Gly Ile
            660                 665                 670         
Cys Thr Cys Thr Asn Asn Gly Thr Cys Asn Pro Ile Asp Arg Ser Cys
        675                 680                 685             
Gln Cys Tyr Pro Gly Trp Ile Gly Ser Asp Cys Ser Gln Pro Cys Pro
    690                 695                 700                 
Pro Ala His Trp Gly Pro Asn Cys Ile His Thr Cys Asn Cys His Asn
705                 710                 715                 720 
Gly Ala Phe Cys Ser Ala Tyr Asp Gly Glu Cys Lys Cys Thr Pro Gly
                725                 730                 735     
Trp Thr Gly Leu Tyr Cys Thr Gln Arg Cys Pro Leu Gly Phe Tyr Gly
            740                 745                 750         
Lys Asp Cys Ala Leu Ile Cys Gln Cys Gln Asn Gly Ala Asp Cys Asp
        755                 760                 765             
His Ile Ser Gly Gln Cys Thr Cys Arg Thr Gly Phe Met Gly Arg His
    770                 775                 780                 
Cys Glu Gln Lys Cys Pro Ser Gly Thr Tyr Gly Tyr Gly Cys Arg Gln
785                 790                 795                 800 
Ile Cys Asp Cys Leu Asn Asn Ser Thr Cys Asp His Ile Thr Gly Thr
                805                 810                 815     
Cys Tyr Cys Ser Pro Gly Trp Lys Gly Ala Arg Cys Asp Gln Ala Gly
            820                 825                 830         
Val Ile Ile Val Gly Asn Leu Asn Ser Leu Ser Arg Thr Ser Thr Ala
        835                 840                 845             
Leu Pro Ala Asp Ser Tyr Gln Ile Gly Ala Ile Ala Gly Ile Ile Ile
    850                 855                 860                 
Leu Val Leu Val Val Leu Phe Leu Leu Ala Leu Phe Ile Ile Tyr Arg
865                 870                 875                 880 
His Lys Gln Lys Gly Lys Glu Ser Ser Met Pro Ala Val Thr Tyr Thr
                885                 890                 895     
Pro Ala Met Arg Val Val Asn Ala Asp Tyr Thr Ile Ser Gly Thr Leu
            900                 905                 910         
Pro His Ser Asn Gly Gly Asn Ala Asn Ser His Tyr Phe Thr Asn Pro
        915                 920                 925             
Ser Tyr His Thr Leu Thr Gln Cys Ala Thr Ser Pro His Val Asn Asn
    930                 935                 940                 
Arg Asp Arg Met Thr Val Thr Lys Ser Lys Asn Asn Gln Leu Phe Val
945                 950                 955                 960 
Asn Leu Lys Asn Val Asn Pro Gly Lys Arg Gly Pro Val Gly Asp Cys
                965                 970                 975     
Thr Gly Thr Leu Pro Ala Asp Trp Lys His Gly Gly Tyr Leu Asn Glu
            980                 985                 990         
Leu Gly Ala Phe Gly Leu Asp Arg Ser Tyr Met Gly Lys Ser Leu Lys
        995                 1000                1005            
Asp Leu Gly Lys Asn Ser Glu Tyr Asn Ser Ser Asn Cys Ser Leu Ser
    1010                1015                1020                
Ser Ser Glu Asn Pro Tyr Ala Thr Ile Lys Asp Pro Pro Val Leu Ile
1025                1030                1035                1040
Pro Lys Ser Ser Glu Cys Gly Tyr Val Glu Met Lys Ser Pro Ala Arg
                1045                1050                1055    
Arg Asp Ser Pro Tyr Ala Glu Ile Asn Asn Ser Thr Ser Ala Asn Arg
            1060                1065                1070        
Asn Val Tyr Glu Val Glu Pro Thr Val Ser Val Val Gln Gly Val Phe
        1075                1080                1085            
Ser Asn Asn Gly Arg Leu Ser Gln Asp Pro Tyr Asp Leu Pro Lys Asn
    1090                1095                1100                
Ser His Ile Pro Cys His Tyr Asp Leu Leu Pro Val Arg Asp Ser Ser
1105                1110                1115                1120
Ser Ser Pro Lys Gln Glu Asp Ser Gly Gly Ser Ser Ser Asn Ser Ser
                1125                1130                1135    
Ser Ser Ser Glu
            1140


<210> 1839
<211> 3911
<212> PRT
<213> Homo sapiens

<400> 1839
Met Glu Asp Glu Glu Arg Gln Lys Lys Leu Glu Ala Gly Lys Ala Lys
 1               5                  10                  15      
Ile Glu Glu Leu Ser Leu Ala Phe Leu Val Arg Gln Leu Ala Gln Phe
            20                  25                  30          
Arg Gln Arg Lys Ala Gln Ser Asp Gly Gln Ser Pro Ser Lys Lys Gln
        35                  40                  45              
Lys Lys Lys Arg Lys Thr Ser Ser Ser Lys His Asp Val Ser Ala His
    50                  55                  60                  
His Asp Leu Asn Ile Asp Gln Ser Gln Cys Asn Glu Met Tyr Ile Asn
65                  70                  75                  80  
Ser Ser Gln Arg Val Glu Ser Thr Val Ile Pro Glu Ser Thr Ile Met
                85                  90                  95      
Arg Thr Leu His Ser Gly Glu Ile Thr Ser His Glu Gln Gly Phe Ser
            100                 105                 110         
Val Glu Leu Glu Ser Glu Ile Ser Thr Thr Ala Asp Asp Cys Ser Ser
        115                 120                 125             
Glu Val Asn Gly Cys Ser Phe Val Met Arg Thr Gly Lys Pro Thr Asn
    130                 135                 140                 
Leu Leu Arg Glu Glu Glu Phe Gly Val Asp Asp Ser Tyr Ser Glu Gln
145                 150                 155                 160 
Gly Ala Gln Asp Ser Pro Thr His Leu Glu Met Met Glu Ser Glu Leu
                165                 170                 175     
Ala Gly Lys Gln His Glu Ile Glu Glu Leu Asn Arg Glu Leu Glu Glu
            180                 185                 190         
Met Arg Val Thr Tyr Gly Thr Glu Gly Leu Gln Gln Leu Gln Glu Phe
        195                 200                 205             
Glu Ala Ala Ile Lys Gln Arg Asp Gly Ile Ile Thr Gln Leu Thr Ala
    210                 215                 220                 
Asn Leu Gln Gln Ala Arg Arg Glu Lys Asp Glu Thr Met Arg Glu Phe
225                 230                 235                 240 
Leu Glu Leu Thr Glu Gln Ser Gln Lys Leu Gln Ile Gln Phe Gln Gln
                245                 250                 255     
Leu Gln Ala Ser Glu Thr Leu Arg Asn Ser Thr His Ser Ser Thr Ala
            260                 265                 270         
Ala Asp Leu Leu Gln Ala Lys Gln Gln Ile Leu Thr His Gln Gln Gln
        275                 280                 285             
Leu Glu Glu Gln Asp His Leu Leu Glu Asp Tyr Gln Lys Lys Lys Glu
    290                 295                 300                 
Asp Phe Thr Met Gln Ile Ser Phe Leu Gln Glu Lys Ile Lys Val Tyr
305                 310                 315                 320 
Glu Met Glu Gln Asp Lys Lys Val Glu Asn Ser Asn Lys Glu Glu Ile
                325                 330                 335     
Gln Glu Lys Glu Thr Ile Ile Glu Glu Leu Asn Thr Lys Ile Ile Glu
            340                 345                 350         
Glu Glu Lys Lys Thr Leu Glu Leu Lys Asp Lys Leu Thr Thr Ala Asp
        355                 360                 365             
Lys Leu Leu Gly Glu Leu Gln Glu Gln Ile Val Gln Lys Asn Gln Glu
    370                 375                 380                 
Ile Lys Asn Met Lys Leu Glu Leu Thr Asn Ser Lys Gln Lys Glu Arg
385                 390                 395                 400 
Gln Ser Ser Glu Glu Ile Lys Gln Leu Met Gly Thr Val Glu Glu Leu
                405                 410                 415     
Gln Lys Arg Asn His Lys Asp Ser Gln Phe Glu Thr Asp Ile Val Gln
            420                 425                 430         
Arg Met Glu Gln Glu Thr Gln Arg Lys Leu Glu Gln Leu Arg Ala Glu
        435                 440                 445             
Leu Asp Glu Met Tyr Gly Gln Gln Ile Val Gln Met Lys Gln Glu Leu
    450                 455                 460                 
Ile Arg Gln His Met Ala Gln Met Glu Glu Met Lys Thr Arg His Lys
465                 470                 475                 480 
Gly Glu Met Glu Asn Ala Leu Arg Ser Tyr Ser Asn Ile Thr Val Asn
                485                 490                 495     
Glu Asp Gln Ile Lys Leu Met Asn Val Ala Ile Asn Glu Leu Asn Ile
            500                 505                 510         
Lys Leu Gln Asp Thr Asn Ser Gln Lys Glu Lys Leu Lys Glu Glu Leu
        515                 520                 525             
Gly Leu Ile Leu Glu Glu Lys Cys Ala Leu Gln Arg Gln Leu Glu Asp
    530                 535                 540                 
Leu Val Glu Glu Leu Ser Phe Ser Arg Glu Gln Ile Gln Arg Ala Arg
545                 550                 555                 560 
Gln Thr Ile Ala Glu Gln Glu Ser Lys Leu Asn Glu Ala His Lys Ser
                565                 570                 575     
Leu Ser Thr Val Glu Asp Leu Lys Ala Glu Ile Val Ser Ala Ser Glu
            580                 585                 590         
Ser Arg Lys Glu Leu Glu Leu Lys His Glu Ala Glu Val Thr Asn Tyr
        595                 600                 605             
Lys Ile Lys Leu Glu Met Leu Glu Lys Glu Lys Asn Ala Val Leu Asp
    610                 615                 620                 
Arg Met Ala Glu Ser Gln Glu Ala Glu Leu Glu Arg Leu Arg Thr Gln
625                 630                 635                 640 
Leu Leu Phe Ser His Glu Glu Glu Leu Ser Lys Leu Lys Glu Asp Leu
                645                 650                 655     
Glu Ile Glu His Arg Ile Asn Ile Glu Lys Leu Lys Asp Asn Leu Gly
            660                 665                 670         
Ile His Tyr Lys Gln Gln Ile Asp Gly Leu Gln Asn Glu Met Ser Gln
        675                 680                 685             
Lys Ile Glu Thr Met Gln Phe Glu Lys Asp Asn Leu Ile Thr Lys Gln
    690                 695                 700                 
Asn Gln Leu Ile Leu Glu Ile Ser Lys Leu Lys Asp Leu Gln Gln Ser
705                 710                 715                 720 
Leu Val Asn Ser Lys Ser Glu Glu Met Thr Leu Gln Ile Asn Glu Leu
                725                 730                 735     
Gln Lys Glu Ile Glu Ile Leu Arg Gln Glu Glu Lys Glu Lys Gly Thr
            740                 745                 750         
Leu Glu Gln Glu Val Gln Glu Leu Gln Leu Lys Thr Glu Leu Leu Glu
        755                 760                 765             
Lys Gln Met Lys Glu Lys Glu Asn Asp Leu Gln Glu Lys Phe Ala Gln
    770                 775                 780                 
Leu Glu Ala Glu Asn Ser Ile Leu Lys Asp Glu Lys Lys Thr Leu Glu
785                 790                 795                 800 
Asp Met Leu Lys Ile His Thr Pro Val Ser Gln Glu Glu Arg Leu Ile
                805                 810                 815     
Phe Leu Asp Ser Ile Lys Ser Lys Ser Lys Asp Ser Val Trp Glu Lys
            820                 825                 830         
Glu Ile Glu Ile Leu Ile Glu Glu Asn Glu Asp Leu Lys Gln Gln Cys
        835                 840                 845             
Ile Gln Leu Asn Glu Glu Ile Glu Lys Gln Arg Asn Thr Phe Ser Phe
    850                 855                 860                 
Ala Glu Lys Asn Phe Glu Val Asn Tyr Gln Glu Leu Gln Glu Glu Tyr
865                 870                 875                 880 
Ala Cys Leu Leu Lys Val Lys Asp Asp Leu Glu Asp Ser Lys Asn Lys
                885                 890                 895     
Gln Glu Leu Glu Tyr Lys Ser Lys Leu Lys Ala Leu Asn Glu Glu Leu
            900                 905                 910         
His Leu Gln Arg Ile Asn Pro Thr Thr Val Lys Met Lys Ser Ser Val
        915                 920                 925             
Phe Asp Glu Asp Lys Thr Phe Val Ala Glu Thr Leu Glu Met Gly Glu
    930                 935                 940                 
Val Val Glu Lys Asp Thr Thr Glu Leu Met Glu Lys Leu Glu Val Thr
945                 950                 955                 960 
Lys Arg Glu Lys Leu Glu Leu Ser Gln Arg Leu Ser Asp Leu Ser Glu
                965                 970                 975     
Gln Leu Lys Gln Lys His Gly Glu Ile Ser Phe Leu Asn Glu Glu Val
            980                 985                 990         
Lys Ser Leu Lys Gln Glu Lys Glu Gln Val Ser Leu Arg Cys Arg Glu
        995                 1000                1005            
Leu Glu Ile Ile Ile Asn His Asn Arg Ala Glu Asn Val Gln Ser Cys
    1010                1015                1020                
Asp Thr Gln Val Ser Ser Leu Leu Asp Gly Val Val Thr Met Thr Ser
1025                1030                1035                1040
Arg Gly Ala Glu Gly Ser Val Ser Lys Val Asn Lys Ser Phe Gly Glu
                1045                1050                1055    
Glu Ser Lys Ile Met Val Glu Asp Lys Val Ser Phe Glu Asn Met Thr
            1060                1065                1070        
Val Gly Glu Glu Ser Lys Gln Glu Gln Leu Ile Leu Asp His Leu Pro
        1075                1080                1085            
Ser Val Thr Lys Glu Ser Ser Leu Arg Ala Thr Gln Pro Ser Glu Asn
    1090                1095                1100                
Asp Lys Leu Gln Lys Glu Leu Asn Val Leu Lys Ser Glu Gln Asn Asp
1105                1110                1115                1120
Leu Arg Leu Gln Met Glu Ala Gln Arg Ile Cys Leu Ser Leu Val Tyr
                1125                1130                1135    
Ser Thr His Val Asp Gln Val Arg Glu Tyr Met Glu Asn Glu Lys Asp
            1140                1145                1150        
Lys Ala Leu Cys Ser Leu Lys Glu Glu Leu Ile Phe Ala Gln Glu Glu
        1155                1160                1165            
Lys Ile Lys Glu Leu Gln Lys Ile His Gln Leu Glu Leu Gln Thr Met
    1170                1175                1180                
Lys Thr Gln Glu Thr Gly Asp Glu Gly Lys Pro Leu His Leu Leu Ile
1185                1190                1195                1200
Gly Lys Leu Gln Lys Ala Val Ser Glu Glu Cys Ser Tyr Phe Leu Gln
                1205                1210                1215    
Thr Leu Cys Ser Val Leu Gly Glu Tyr Tyr Thr Pro Ala Leu Lys Cys
            1220                1225                1230        
Glu Val Asn Ala Glu Asp Lys Glu Asn Ser Gly Asp Tyr Ile Ser Glu
        1235                1240                1245            
Asn Glu Asp Pro Glu Leu Gln Asp Tyr Arg Tyr Glu Val Gln Asp Phe
    1250                1255                1260                
Gln Glu Asn Met His Thr Leu Leu Asn Lys Val Thr Glu Glu Tyr Asn
1265                1270                1275                1280
Lys Leu Leu Val Leu Gln Thr Arg Leu Ser Lys Ile Trp Gly Gln Gln
                1285                1290                1295    
Thr Asp Gly Met Lys Leu Glu Phe Gly Glu Glu Asn Leu Pro Lys Glu
            1300                1305                1310        
Glu Thr Glu Phe Leu Ser Ile His Ser Gln Met Thr Asn Leu Glu Asp
        1315                1320                1325            
Ile Asp Val Asn His Lys Ser Lys Leu Ser Ser Leu Gln Asp Leu Glu
    1330                1335                1340                
Lys Thr Lys Leu Glu Glu Gln Val Gln Glu Leu Glu Ser Leu Ile Ser
1345                1350                1355                1360
Ser Leu Gln Gln Gln Leu Lys Glu Thr Glu Gln Asn Tyr Glu Ala Glu
                1365                1370                1375    
Ile His Cys Leu Gln Lys Arg Leu Gln Ala Val Ser Glu Ser Thr Val
            1380                1385                1390        
Pro Pro Ser Leu Pro Val Asp Ser Val Val Ile Thr Glu Ser Asp Ala
        1395                1400                1405            
Gln Arg Thr Met Tyr Pro Gly Ser Cys Val Lys Lys Asn Ile Asp Gly
    1410                1415                1420                
Thr Ile Glu Phe Ser Gly Glu Phe Gly Val Lys Glu Glu Thr Asn Ile
1425                1430                1435                1440
Val Lys Leu Leu Glu Lys Gln Tyr Gln Glu Gln Leu Glu Glu Glu Val
                1445                1450                1455    
Ala Lys Val Ile Val Ser Met Ser Ile Ala Phe Ala Gln Gln Thr Glu
            1460                1465                1470        
Leu Ser Arg Ile Ser Gly Gly Lys Glu Asn Thr Ala Ser Ser Lys Gln
        1475                1480                1485            
Ala His Ala Val Cys Gln Gln Glu Gln His Tyr Phe Asn Glu Met Lys
    1490                1495                1500                
Leu Ser Gln Asp Gln Ile Gly Phe Gln Thr Phe Glu Thr Val Asp Val
1505                1510                1515                1520
Lys Phe Lys Glu Glu Phe Lys Pro Leu Ser Lys Glu Leu Gly Glu His
                1525                1530                1535    
Gly Lys Glu Ile Leu Leu Ser Asn Ser Asp Pro His Asp Ile Pro Glu
            1540                1545                1550        
Ser Lys Asp Cys Val Leu Thr Ile Ser Glu Glu Met Phe Ser Lys Asp
        1555                1560                1565            
Lys Thr Phe Ile Val Arg Gln Ser Ile His Asp Glu Ile Ser Val Ser
    1570                1575                1580                
Ser Met Asp Ala Ser Arg Gln Leu Met Leu Asn Glu Glu Gln Leu Glu
1585                1590                1595                1600
Asp Met Arg Gln Glu Leu Val Arg Gln Tyr Gln Glu His Gln Gln Ala
                1605                1610                1615    
Thr Glu Leu Leu Arg Gln Ala His Met Arg Gln Met Glu Arg Gln Arg
            1620                1625                1630        
Glu Asp Gln Glu Gln Leu Gln Glu Glu Ile Lys Arg Leu Asn Arg Gln
        1635                1640                1645            
Leu Ala Gln Arg Ser Ser Ile Asp Asn Glu Asn Leu Val Ser Glu Arg
    1650                1655                1660                
Glu Arg Val Leu Leu Glu Glu Leu Glu Ala Leu Lys Gln Leu Ser Leu
1665                1670                1675                1680
Ala Gly Arg Glu Lys Leu Cys Cys Glu Leu Arg Asn Ser Ser Thr Gln
                1685                1690                1695    
Thr Gln Asn Gly Asn Glu Asn Gln Gly Glu Val Glu Glu Gln Thr Phe
            1700                1705                1710        
Lys Glu Lys Glu Leu Asp Arg Lys Pro Glu Asp Val Pro Pro Glu Ile
        1715                1720                1725            
Leu Ser Asn Glu Arg Tyr Ala Leu Gln Lys Ala Asn Asn Arg Leu Leu
    1730                1735                1740                
Lys Ile Leu Leu Glu Val Val Lys Thr Thr Ala Ala Val Glu Glu Thr
1745                1750                1755                1760
Ile Gly Arg His Val Leu Gly Ile Leu Asp Arg Ser Ser Lys Ser Gln
                1765                1770                1775    
Ser Ser Ala Ser Leu Ile Trp Arg Ser Glu Ala Glu Ala Ser Val Lys
            1780                1785                1790        
Ser Cys Val His Glu Glu His Thr Arg Val Thr Asp Glu Ser Ile Pro
        1795                1800                1805            
Ser Tyr Ser Gly Ser Asp Met Pro Arg Asn Asp Ile Asn Met Trp Ser
    1810                1815                1820                
Lys Val Thr Glu Glu Gly Thr Glu Leu Ser Gln Arg Leu Val Arg Ser
1825                1830                1835                1840
Gly Phe Ala Gly Thr Glu Ile Asp Pro Glu Asn Glu Glu Leu Met Leu
                1845                1850                1855    
Asn Ile Ser Ser Arg Leu Gln Ala Ala Val Glu Lys Leu Leu Glu Ala
            1860                1865                1870        
Ile Ser Glu Thr Ser Ser Gln Leu Glu His Ala Lys Val Thr Gln Thr
        1875                1880                1885            
Glu Leu Met Arg Glu Ser Phe Arg Gln Lys Gln Glu Ala Thr Glu Ser
    1890                1895                1900                
Leu Lys Cys Gln Glu Glu Leu Arg Glu Arg Leu His Glu Glu Ser Arg
1905                1910                1915                1920
Ala Arg Glu Gln Leu Ala Val Glu Leu Ser Lys Ala Glu Gly Val Ile
                1925                1930                1935    
Asp Gly Tyr Ala Asp Glu Lys Thr Leu Phe Glu Arg Gln Ile Gln Glu
            1940                1945                1950        
Lys Thr Asp Ile Ile Asp Arg Leu Glu Gln Glu Leu Leu Cys Ala Ser
        1955                1960                1965            
Asn Arg Leu Gln Glu Leu Glu Ala Glu Gln Gln Gln Ile Gln Glu Glu
    1970                1975                1980                
Arg Glu Leu Leu Ser Arg Gln Lys Glu Ala Met Lys Ala Glu Ala Gly
1985                1990                1995                2000
Pro Val Glu Gln Gln Leu Leu Gln Glu Thr Glu Lys Leu Met Lys Glu
                2005                2010                2015    
Lys Leu Glu Val Gln Cys Gln Ala Glu Lys Val Arg Asp Asp Leu Gln
            2020                2025                2030        
Lys Gln Val Lys Ala Leu Glu Ile Asp Val Glu Glu Gln Val Ser Arg
        2035                2040                2045            
Phe Ile Glu Leu Glu Gln Glu Lys Asn Thr Glu Leu Met Asp Leu Arg
    2050                2055                2060                
Gln Gln Asn Gln Ala Leu Glu Lys Gln Leu Glu Lys Met Arg Lys Phe
2065                2070                2075                2080
Leu Asp Glu Gln Ala Ile Asp Arg Glu His Glu Arg Asp Val Phe Gln
                2085                2090                2095    
Gln Glu Ile Gln Lys Leu Glu Gln Gln Leu Lys Val Val Pro Arg Phe
            2100                2105                2110        
Gln Pro Ile Ser Glu His Gln Thr Arg Glu Val Glu Gln Leu Ala Asn
        2115                2120                2125            
His Leu Lys Glu Lys Thr Asp Lys Cys Ser Glu Leu Leu Leu Ser Lys
    2130                2135                2140                
Glu Gln Leu Gln Arg Asp Ile Gln Glu Arg Asn Glu Glu Ile Glu Lys
2145                2150                2155                2160
Leu Glu Phe Arg Val Arg Glu Leu Glu Gln Ala Leu Leu Val Ser Ala
                2165                2170                2175    
Asp Thr Phe Gln Lys Val Glu Asp Arg Lys His Phe Gly Ala Val Glu
            2180                2185                2190        
Ala Lys Pro Glu Leu Ser Leu Glu Val Gln Leu Gln Ala Glu Arg Asp
        2195                2200                2205            
Ala Ile Asp Arg Lys Glu Lys Glu Ile Thr Asn Leu Glu Glu Gln Leu
    2210                2215                2220                
Glu Gln Phe Arg Glu Glu Leu Glu Asn Lys Asn Glu Glu Val Gln Gln
2225                2230                2235                2240
Leu His Met Gln Leu Glu Ile Gln Lys Lys Glu Ser Thr Thr Arg Leu
                2245                2250                2255    
Gln Glu Leu Glu Gln Glu Asn Lys Leu Phe Lys Asp Asp Met Glu Lys
            2260                2265                2270        
Leu Gly Leu Ala Ile Lys Glu Ser Asp Ala Met Ser Thr Gln Asp Gln
        2275                2280                2285            
His Val Leu Phe Gly Lys Phe Ala Gln Ile Ile Gln Glu Lys Glu Val
    2290                2295                2300                
Glu Ile Asp Gln Leu Asn Glu Gln Val Thr Lys Leu Gln Gln Gln Leu
2305                2310                2315                2320
Lys Ile Thr Thr Asp Asn Lys Val Ile Glu Glu Lys Asn Glu Leu Ile
                2325                2330                2335    
Arg Asp Leu Glu Thr Gln Ile Glu Cys Leu Met Ser Asp Gln Glu Cys
            2340                2345                2350        
Val Lys Arg Asn Arg Glu Glu Glu Ile Glu Gln Leu Asn Glu Val Ile
        2355                2360                2365            
Glu Lys Leu Gln Gln Glu Leu Ala Asn Ile Gly Gln Lys Thr Ser Met
    2370                2375                2380                
Asn Ala His Ser Leu Ser Glu Glu Ala Asp Ser Leu Lys His Gln Leu
2385                2390                2395                2400
Asp Val Val Ile Ala Glu Lys Leu Ala Leu Glu Gln Gln Val Glu Thr
                2405                2410                2415    
Ala Asn Glu Glu Met Thr Phe Met Lys Asn Val Leu Lys Glu Thr Asn
            2420                2425                2430        
Phe Lys Met Asn Gln Leu Thr Gln Glu Leu Phe Ser Leu Lys Arg Glu
        2435                2440                2445            
Arg Glu Ser Val Glu Lys Ile Gln Ser Ile Pro Glu Asn Ser Val Asn
    2450                2455                2460                
Val Ala Ile Asp His Leu Ser Lys Asp Lys Pro Glu Leu Glu Val Val
2465                2470                2475                2480
Leu Thr Glu Asp Ala Leu Lys Ser Leu Glu Asn Gln Thr Tyr Phe Lys
                2485                2490                2495    
Ser Phe Glu Glu Asn Gly Lys Gly Ser Ile Ile Asn Leu Glu Thr Arg
            2500                2505                2510        
Leu Leu Gln Leu Glu Ser Thr Val Ser Ala Lys Asp Leu Glu Leu Thr
        2515                2520                2525            
Gln Cys Tyr Lys Gln Ile Lys Asp Met Gln Glu Gln Gly Gln Phe Glu
    2530                2535                2540                
Thr Glu Met Leu Gln Lys Lys Ile Val Asn Leu Gln Lys Ile Val Glu
2545                2550                2555                2560
Glu Lys Val Ala Ala Ala Leu Val Ser Gln Ile Gln Leu Glu Ala Val
                2565                2570                2575    
Gln Glu Tyr Ala Lys Phe Cys Gln Asp Asn Gln Thr Ile Ser Ser Glu
            2580                2585                2590        
Pro Glu Arg Thr Asn Ile Gln Asn Leu Asn Gln Leu Arg Glu Asp Glu
        2595                2600                2605            
Leu Gly Ser Asp Ile Ser Ala Leu Thr Leu Arg Ile Ser Glu Leu Glu
    2610                2615                2620                
Ser Gln Val Val Glu Met His Thr Ser Leu Ile Leu Glu Lys Glu Gln
2625                2630                2635                2640
Val Glu Ile Ala Glu Lys Asn Val Leu Glu Lys Glu Lys Lys Leu Leu
                2645                2650                2655    
Glu Leu Gln Lys Leu Leu Glu Gly Asn Glu Lys Lys Gln Arg Glu Lys
            2660                2665                2670        
Glu Lys Lys Arg Ser Pro Gln Asp Val Glu Val Leu Lys Thr Thr Thr
        2675                2680                2685            
Glu Leu Phe His Ser Asn Glu Glu Ser Gly Phe Phe Asn Glu Leu Glu
    2690                2695                2700                
Ala Leu Arg Ala Glu Ser Val Ala Thr Lys Ala Glu Leu Ala Ser Tyr
2705                2710                2715                2720
Lys Glu Lys Ala Glu Lys Leu Gln Glu Glu Leu Leu Val Lys Glu Thr
                2725                2730                2735    
Asn Met Thr Ser Leu Gln Lys Asp Leu Ser Gln Val Arg Asp His Leu
            2740                2745                2750        
Ala Glu Ala Lys Glu Lys Leu Ser Ile Leu Glu Lys Glu Asp Glu Thr
        2755                2760                2765            
Glu Val Gln Glu Ser Lys Lys Ala Cys Met Phe Glu Pro Leu Pro Ile
    2770                2775                2780                
Lys Leu Ser Lys Ser Ile Ala Ser Gln Thr Asp Gly Thr Leu Lys Ile
2785                2790                2795                2800
Ser Ser Ser Asn Gln Thr Pro Gln Ile Leu Val Lys Asn Ala Gly Ile
                2805                2810                2815    
Gln Ile Asn Leu Gln Ser Glu Cys Ser Ser Glu Glu Val Thr Glu Ile
            2820                2825                2830        
Ile Ser Gln Phe Thr Glu Lys Ile Glu Lys Met Gln Glu Leu His Ala
        2835                2840                2845            
Ala Glu Ile Leu Asp Met Glu Ser Arg His Ile Ser Glu Thr Glu Thr
    2850                2855                2860                
Leu Lys Arg Glu His Tyr Val Ala Val Gln Leu Leu Lys Glu Glu Cys
2865                2870                2875                2880
Gly Thr Leu Lys Ala Val Ile Gln Cys Leu Arg Ser Lys Glu Val Phe
                2885                2890                2895    
Gly Phe Tyr Asn Met Cys Phe Ser Thr Leu Cys Asp Ser Gly Ser Asp
            2900                2905                2910        
Trp Gly Gln Gly Ile Tyr Leu Thr His Ser Gln Gly Phe Asp Ile Ala
        2915                2920                2925            
Ser Glu Gly Arg Gly Glu Glu Ser Glu Ser Ala Thr Asp Ser Phe Pro
    2930                2935                2940                
Lys Lys Ile Lys Gly Leu Leu Arg Ala Val His Asn Glu Gly Met Gln
2945                2950                2955                2960
Val Leu Ser Leu Thr Glu Ser Pro Tyr Ser Asp Gly Glu Asp His Ser
                2965                2970                2975    
Ile Gln Gln Val Ser Glu Pro Trp Leu Glu Glu Arg Lys Ala Tyr Ile
            2980                2985                2990        
Asn Thr Ile Ser Ser Leu Lys Asp Leu Ile Thr Lys Met Gln Leu Gln
        2995                3000                3005            
Arg Glu Ala Glu Val Tyr Asp Ser Ser Gln Ser His Glu Ser Phe Ser
    3010                3015                3020                
Asp Trp Arg Gly Glu Leu Leu Leu Ala Leu Gln Gln Val Phe Leu Glu
3025                3030                3035                3040
Glu Arg Ser Val Leu Leu Ala Ala Phe Arg Thr Glu Leu Thr Ala Leu
                3045                3050                3055    
Gly Thr Thr Asp Ala Val Gly Leu Leu Asn Cys Leu Glu Gln Arg Ile
            3060                3065                3070        
Gln Glu Gln Gly Val Glu Tyr Gln Ala Ala Met Glu Cys Leu Gln Lys
        3075                3080                3085            
Ala Asp Arg Arg Ser Leu Leu Ser Glu Ile Gln Ala Leu His Ala Gln
    3090                3095                3100                
Met Asn Gly Arg Lys Ile Thr Leu Lys Arg Glu Gln Glu Ser Glu Lys
3105                3110                3115                3120
Pro Ser Gln Glu Leu Leu Glu Tyr Asn Ile Gln Gln Lys Gln Ser Gln
                3125                3130                3135    
Met Leu Glu Met Gln Val Glu Leu Ser Ser Met Lys Asp Arg Ala Thr
            3140                3145                3150        
Glu Leu Gln Glu Gln Leu Ser Ser Glu Lys Met Val Val Ala Glu Leu
        3155                3160                3165            
Lys Ser Glu Leu Ala Gln Thr Lys Leu Glu Leu Glu Thr Thr Leu Lys
    3170                3175                3180                
Ala Gln His Lys His Leu Lys Glu Leu Glu Ala Phe Arg Leu Glu Val
3185                3190                3195                3200
Lys Asp Lys Thr Asp Glu Val His Leu Leu Asn Asp Thr Leu Ala Ser
                3205                3210                3215    
Glu Gln Lys Lys Ser Arg Glu Leu Gln Trp Ala Leu Glu Lys Glu Lys
            3220                3225                3230        
Ala Lys Leu Gly Arg Ser Glu Glu Arg Asp Lys Glu Glu Leu Glu Asp
        3235                3240                3245            
Leu Lys Phe Ser Leu Glu Ser Gln Lys Gln Arg Asn Leu Gln Leu Asn
    3250                3255                3260                
Leu Leu Leu Glu Gln Gln Lys Gln Leu Leu Asn Glu Ser Gln Gln Lys
3265                3270                3275                3280
Ile Glu Ser Gln Arg Met Leu Tyr Asp Ala Gln Leu Ser Glu Glu Gln
                3285                3290                3295    
Gly Arg Asn Leu Glu Leu Gln Val Leu Leu Glu Ser Glu Lys Val Arg
            3300                3305                3310        
Ile Arg Glu Met Ser Ser Thr Leu Asp Arg Glu Arg Glu Leu His Ala
        3315                3320                3325            
Gln Leu Gln Ser Ser Asp Gly Thr Gly Gln Ser Arg Pro Pro Leu Pro
    3330                3335                3340                
Ser Glu Asp Leu Leu Lys Glu Leu Gln Lys Gln Leu Glu Glu Lys His
3345                3350                3355                3360
Ser Arg Ile Val Glu Leu Leu Asn Glu Thr Glu Lys Tyr Lys Leu Asp
                3365                3370                3375    
Ser Leu Gln Thr Arg Gln Gln Met Glu Lys Asp Arg Gln Val His Arg
            3380                3385                3390        
Lys Thr Leu Gln Thr Glu Gln Glu Ala Asn Thr Glu Gly Gln Lys Lys
        3395                3400                3405            
Met His Glu Leu Gln Ser Lys Val Glu Asp Leu Gln Arg Gln Leu Glu
    3410                3415                3420                
Glu Lys Arg Gln Gln Val Tyr Lys Leu Asp Leu Glu Gly Gln Arg Leu
3425                3430                3435                3440
Gln Gly Ile Met Gln Glu Phe Gln Lys Gln Glu Leu Glu Arg Glu Glu
                3445                3450                3455    
Lys Arg Glu Ser Arg Arg Ile Leu Tyr Gln Asn Leu Asn Glu Pro Thr
            3460                3465                3470        
Thr Trp Ser Leu Thr Ser Asp Arg Thr Arg Asn Trp Val Leu Gln Gln
        3475                3480                3485            
Lys Ile Glu Gly Glu Thr Lys Glu Ser Asn Tyr Ala Lys Leu Ile Glu
    3490                3495                3500                
Met Asn Gly Gly Gly Thr Gly Cys Asn His Glu Leu Glu Met Ile Arg
3505                3510                3515                3520
Gln Lys Leu Gln Cys Val Ala Ser Lys Leu Gln Val Leu Pro Gln Lys
                3525                3530                3535    
Ala Ser Glu Arg Leu Gln Phe Glu Thr Ala Asp Asp Glu Asp Phe Ile
            3540                3545                3550        
Trp Val Gln Glu Asn Ile Asp Glu Ile Ile Leu Gln Leu Gln Lys Leu
        3555                3560                3565            
Thr Gly Gln Gln Gly Glu Glu Pro Ser Leu Val Ser Pro Ser Thr Ser
    3570                3575                3580                
Cys Gly Ser Leu Thr Glu Arg Leu Leu Arg Gln Asn Ala Glu Leu Thr
3585                3590                3595                3600
Gly His Ile Ser Gln Leu Thr Glu Glu Lys Asn Asp Leu Arg Asn Met
                3605                3610                3615    
Val Met Lys Leu Glu Glu Gln Ile Arg Trp Tyr Arg Gln Thr Gly Ala
            3620                3625                3630        
Gly Arg Asp Asn Ser Ser Arg Phe Ser Leu Asn Gly Gly Ala Asn Ile
        3635                3640                3645            
Glu Ala Ile Ile Ala Ser Glu Lys Glu Val Trp Asn Arg Glu Lys Leu
    3650                3655                3660                
Thr Leu Gln Lys Ser Leu Lys Arg Ala Glu Ala Glu Val Tyr Lys Leu
3665                3670                3675                3680
Lys Ala Glu Leu Arg Asn Asp Ser Leu Leu Gln Thr Leu Ser Pro Asp
                3685                3690                3695    
Ser Glu His Val Thr Leu Lys Arg Ile Tyr Gly Lys Tyr Leu Arg Ala
            3700                3705                3710        
Glu Ser Phe Arg Lys Ala Leu Ile Tyr Gln Lys Lys Tyr Leu Leu Leu
        3715                3720                3725            
Leu Leu Gly Gly Phe Gln Glu Cys Glu Asp Ala Thr Leu Ala Leu Leu
    3730                3735                3740                
Ala Arg Met Gly Gly Gln Pro Ala Phe Thr Asp Leu Glu Val Ile Thr
3745                3750                3755                3760
Asn Arg Pro Lys Gly Phe Thr Arg Phe Arg Ser Ala Val Arg Val Ser
                3765                3770                3775    
Ile Ala Ile Ser Arg Met Lys Phe Leu Val Arg Arg Trp His Arg Val
            3780                3785                3790        
Thr Gly Ser Val Ser Ile Asn Ile Asn Arg Asp Gly Phe Gly Leu Asn
        3795                3800                3805            
Gln Gly Ala Glu Lys Thr Asp Ser Phe Tyr His Ser Ser Gly Gly Leu
    3810                3815                3820                
Glu Leu Tyr Gly Glu Pro Arg His Thr Thr Tyr Arg Ser Arg Ser Asp
3825                3830                3835                3840
Leu Asp Tyr Ile Arg Ser Pro Leu Pro Phe Gln Asn Arg Tyr Pro Gly
                3845                3850                3855    
Thr Pro Ala Asp Phe Asn Pro Gly Ser Leu Ala Cys Ser Gln Leu Gln
            3860                3865                3870        
Asn Tyr Asp Pro Asp Arg Ala Leu Thr Asp Tyr Ile Thr Arg Leu Glu
        3875                3880                3885            
Ala Leu Gln Arg Arg Leu Gly Thr Ile Gln Ser Gly Ser Thr Thr Gln
    3890                3895                3900                
Phe His Ala Gly Met Arg Arg
3905                3910    


<210> 1840
<211> 820
<212> PRT
<213> Homo sapiens

<400> 1840
Met Ile Pro Ala Arg Leu His Arg Asp Tyr Lys Gly Leu Val Leu Leu
 1               5                  10                  15      
Gly Ile Leu Leu Gly Thr Leu Trp Glu Thr Gly Cys Thr Gln Ile Arg
            20                  25                  30          
Tyr Ser Val Pro Glu Glu Leu Glu Lys Gly Ser Arg Val Gly Asp Ile
        35                  40                  45              
Ser Arg Asp Leu Gly Leu Glu Pro Arg Glu Leu Ala Glu Arg Gly Val
    50                  55                  60                  
Arg Ile Ile Pro Arg Gly Arg Thr Gln Leu Phe Ala Leu Asn Pro Arg
65                  70                  75                  80  
Ser Gly Ser Leu Val Thr Ala Gly Arg Ile Asp Arg Glu Glu Leu Cys
                85                  90                  95      
Met Gly Ala Ile Lys Cys Gln Leu Asn Leu Asp Ile Leu Met Glu Asp
            100                 105                 110         
Lys Val Lys Ile Tyr Gly Val Glu Val Glu Val Arg Asp Ile Asn Asp
        115                 120                 125             
Asn Ala Pro Tyr Phe Arg Glu Ser Glu Leu Glu Ile Lys Ile Ser Glu
    130                 135                 140                 
Asn Ala Ala Thr Glu Met Arg Phe Pro Leu Pro His Ala Trp Asp Pro
145                 150                 155                 160 
Asp Ile Gly Lys Asn Ser Leu Gln Ser Tyr Glu Leu Ser Pro Asn Thr
                165                 170                 175     
His Phe Ser Leu Ile Val Gln Asn Gly Ala Asp Gly Ser Lys Tyr Pro
            180                 185                 190         
Glu Leu Val Leu Lys Arg Ala Leu Asp Arg Glu Glu Lys Ala Ala His
        195                 200                 205             
His Leu Val Leu Thr Ala Ser Asp Gly Gly Asp Pro Val Arg Thr Gly
    210                 215                 220                 
Thr Ala Arg Ile Arg Val Met Val Leu Asp Ala Asn Asp Asn Ala Pro
225                 230                 235                 240 
Ala Phe Ala Gln Pro Glu Tyr Arg Ala Ser Val Pro Glu Asn Leu Ala
                245                 250                 255     
Leu Gly Thr Gln Leu Leu Val Val Asn Ala Thr Asp Pro Asp Glu Gly
            260                 265                 270         
Val Asn Ala Glu Val Arg Tyr Ser Phe Arg Tyr Val Asp Asp Lys Ala
        275                 280                 285             
Ala Gln Val Phe Lys Leu Asp Cys Asn Ser Gly Thr Ile Ser Thr Ile
    290                 295                 300                 
Gly Glu Leu Asp His Glu Glu Ser Gly Phe Tyr Gln Met Glu Val Gln
305                 310                 315                 320 
Ala Met Asp Asn Ala Gly Tyr Ser Ala Arg Ala Lys Val Leu Ile Thr
                325                 330                 335     
Val Leu Asp Val Asn Asp Asn Ala Pro Glu Val Val Leu Thr Ser Leu
            340                 345                 350         
Ala Ser Ser Val Pro Glu Asn Ser Pro Arg Gly Thr Leu Ile Ala Leu
        355                 360                 365             
Leu Asn Val Asn Asp Gln Asp Ser Glu Glu Asn Gly Gln Val Ile Cys
    370                 375                 380                 
Phe Ile Gln Gly Asn Leu Pro Phe Lys Leu Glu Lys Ser Tyr Gly Asn
385                 390                 395                 400 
Tyr Tyr Ser Leu Val Thr Asp Ile Val Leu Asp Arg Glu Gln Val Pro
                405                 410                 415     
Ser Tyr Asn Ile Thr Val Thr Ala Thr Asp Arg Gly Thr Pro Pro Leu
            420                 425                 430         
Ser Thr Glu Thr His Ile Ser Leu Asn Val Ala Asp Thr Asn Asp Asn
        435                 440                 445             
Pro Pro Val Phe Pro Gln Ala Ser Tyr Ser Ala Tyr Ile Pro Glu Asn
    450                 455                 460                 
Asn Pro Arg Gly Val Ser Leu Val Ser Val Thr Ala His Asp Pro Asp
465                 470                 475                 480 
Cys Glu Glu Asn Ala Gln Ile Thr Tyr Ser Leu Ala Glu Asn Thr Ile
                485                 490                 495     
Gln Gly Ala Ser Leu Ser Ser Tyr Val Ser Ile Asn Ser Asp Thr Gly
            500                 505                 510         
Val Leu Tyr Ala Leu Ser Ser Phe Asp Tyr Glu Gln Phe Arg Asp Leu
        515                 520                 525             
Gln Val Lys Val Met Ala Arg Asp Asn Gly His Pro Pro Leu Ser Ser
    530                 535                 540                 
Asn Val Ser Leu Ser Leu Phe Val Leu Asp Gln Asn Asp Asn Ala Pro
545                 550                 555                 560 
Glu Ile Leu Tyr Pro Ala Leu Pro Thr Asp Gly Ser Thr Gly Val Glu
                565                 570                 575     
Leu Ala Pro Arg Ser Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val
            580                 585                 590         
Ala Val Asp Arg Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Arg Leu
        595                 600                 605             
Leu Lys Ala Ser Glu Pro Gly Leu Phe Ser Val Gly Leu His Thr Gly
    610                 615                 620                 
Glu Val Arg Thr Ala Arg Ala Leu Leu Asp Arg Asp Ala Leu Lys Gln
625                 630                 635                 640 
Ser Leu Val Val Ala Val Gln Asp His Gly Gln Pro Pro Leu Ser Ala
                645                 650                 655     
Thr Val Thr Leu Thr Val Ala Val Ala Asp Ser Ile Pro Gln Val Leu
            660                 665                 670         
Ala Asp Leu Gly Ser Leu Glu Ser Pro Ala Asn Ser Glu Thr Ser Asp
        675                 680                 685             
Leu Thr Leu Tyr Leu Val Val Ala Val Ala Ala Val Ser Cys Val Phe
    690                 695                 700                 
Leu Ala Phe Val Ile Leu Leu Leu Ala Leu Arg Leu Arg Arg Trp His
705                 710                 715                 720 
Lys Ser Arg Leu Leu Gln Ala Ser Gly Gly Gly Leu Thr Gly Ala Pro
                725                 730                 735     
Ala Ser His Phe Val Gly Val Asp Gly Val Gln Ala Phe Leu Gln Thr
            740                 745                 750         
Tyr Ser His Glu Val Ser Leu Thr Thr Asp Ser Arg Lys Ser His Leu
        755                 760                 765             
Ile Phe Pro Gln Pro Asn Tyr Ala Asp Met Leu Val Ser Gln Glu Ser
    770                 775                 780                 
Phe Glu Lys Ser Glu Pro Leu Leu Leu Ser Gly Asp Ser Val Phe Ser
785                 790                 795                 800 
Lys Asp Ser His Gly Leu Ile Glu Val Ser Leu Tyr Gln Ile Phe Phe
                805                 810                 815     
Leu Phe Phe Phe
            820 


<210> 1841
<211> 829
<212> PRT
<213> Homo sapiens

<400> 1841
Met Thr Asn Cys Leu Ser Phe Arg Asn Gly Arg Gly Leu Ala Leu Leu
 1               5                  10                  15      
Cys Ala Leu Leu Gly Thr Leu Cys Glu Thr Gly Ser Gly Gln Ile Arg
            20                  25                  30          
Tyr Ser Val Ser Glu Glu Leu Asp Lys Gly Ser Phe Val Gly Asn Ile
        35                  40                  45              
Ala Asn Asp Leu Gly Leu Glu Pro Arg Glu Leu Ala Glu Arg Gly Val
    50                  55                  60                  
Arg Ile Val Ser Arg Gly Arg Thr Gln Leu Phe Ser Leu Asn Pro Gln
65                  70                  75                  80  
Ser Gly Ser Leu Val Thr Ala Glu Arg Ile Asp Arg Glu Glu Leu Cys
                85                  90                  95      
Ala Gln Ile Pro Leu Cys Leu Val Lys Ile Asn Ile Leu Val Glu Asp
            100                 105                 110         
Lys Leu Lys Ile Phe Glu Val Glu Ile Glu Ile Lys Asp Ile Asn Asp
        115                 120                 125             
Asn Ala Pro Asn Phe Pro Thr Glu Glu Leu Glu Ile Lys Ile Gly Glu
    130                 135                 140                 
Leu Thr Val Pro Gly Thr Arg Phe Pro Ile Lys Thr Ala Phe Asp Pro
145                 150                 155                 160 
Asp Val Gly Ile Asn Ser Leu Gln Asn Tyr Lys Leu Ser Pro Asn Asp
                165                 170                 175     
Tyr Phe Ser Leu Ala Val Asn Ser Val Ser Glu Gly Ala Lys Tyr Pro
            180                 185                 190         
Glu Leu Val Leu Glu Arg Ala Leu Asp Arg Glu Lys Lys Glu Ile His
        195                 200                 205             
Gln Leu Val Leu Val Ala Ser Asp Gly Gly Asp Pro Val His Ser Gly
    210                 215                 220                 
Asn Leu His Ile Gln Val Ile Val Leu Asp Ala Asn Asp Asn Pro Pro
225                 230                 235                 240 
Met Phe Thr Gln Pro Glu Tyr Arg Val Ser Val Trp Glu Asn Val Pro
                245                 250                 255     
Val Gly Thr Arg Leu Leu Thr Val Asn Ala Thr Asp Pro Asp Glu Gly
            260                 265                 270         
Phe Asn Ala Gln Val Ser Tyr Ile Leu Asp Lys Met Pro Gly Lys Ile
        275                 280                 285             
Ala Glu Ile Phe His Leu Asn Ser Val Ser Gly Glu Val Ser Ile Leu
    290                 295                 300                 
Lys Ser Leu Asp Tyr Glu Asp Ala Met Phe Tyr Glu Ile Lys Ile Glu
305                 310                 315                 320 
Ala Gln Asp Gly Pro Gly Leu Leu Ser Arg Ala Lys Ile Leu Val Thr
                325                 330                 335     
Val Leu Asp Val Asn Asp Asn Ala Pro Glu Ile Thr Ile Thr Ser Leu
            340                 345                 350         
Thr Ser Ser Val Pro Glu Glu Gly Thr Val Gly Arg Glu Ile Ala Leu
        355                 360                 365             
Ile Asp Val His Asp Arg Asp Ser Gly Gln Asn Gly Gln Val Glu Val
    370                 375                 380                 
Phe Val Leu Gly Asn Leu Pro Phe Lys Leu Glu Lys Ser Ile Asp Gln
385                 390                 395                 400 
Tyr Tyr Arg Leu Val Thr Ala Thr Ser Leu Asp Arg Glu Gln Ile Ser
                405                 410                 415     
Glu Tyr Asn Ile Ser Leu Arg Ala Ser Asp Gly Gly Ser Pro Pro Leu
            420                 425                 430         
Ser Thr Glu Thr His Ile Thr Leu His Val Ile Asp Ile Asn Asp Asn
        435                 440                 445             
Pro Pro Thr Phe Pro His Leu Ser Tyr Ser Ala Tyr Ile Pro Glu Asn
    450                 455                 460                 
Asn Pro Arg Gly Ala Ser Ile Phe Ser Val Thr Ala Gln Asp Pro Asp
465                 470                 475                 480 
Ser Asn Asn Asn Ala Arg Ile Thr Tyr Ala Leu Thr Glu Asp Thr Leu
                485                 490                 495     
Gln Gly Ala Pro Leu Ser Ser Phe Val Ser Ile Asn Ser Asn Thr Gly
            500                 505                 510         
Val Leu Tyr Ala Leu Arg Ser Phe Asp Tyr Glu Gln Phe Arg Asp Leu
        515                 520                 525             
Lys Leu Leu Val Thr Ala Ser Asp Ser Gly Asn Pro Pro Leu Ser Ser
    530                 535                 540                 
Asn Val Ser Leu Asn Leu Phe Val Leu Asp Gln Asn Asp Asn Ala Pro
545                 550                 555                 560 
Glu Ile Leu Tyr Pro Ala Leu Pro Thr Asp Gly Ser Thr Gly Val Glu
                565                 570                 575     
Leu Ala Pro Arg Ser Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val
            580                 585                 590         
Ala Val Asp Arg Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Arg Leu
        595                 600                 605             
Leu Lys Ala Ser Glu Pro Gly Leu Phe Ser Val Gly Leu His Thr Gly
    610                 615                 620                 
Glu Val Arg Thr Ala Arg Ala Leu Leu Asp Arg Asp Ala Leu Lys Gln
625                 630                 635                 640 
Ser Leu Val Val Ala Val Gln Asp His Gly Gln Pro Pro Leu Ser Ala
                645                 650                 655     
Thr Val Thr Leu Thr Val Ala Val Ala Asp Arg Ile Pro Asp Ile Leu
            660                 665                 670         
Ala Asp Leu Gly Ser Leu Glu Pro Ser Ala Lys Pro Asn Asp Ser Asp
        675                 680                 685             
Leu Thr Leu Tyr Leu Val Val Ala Val Ala Ala Val Ser Cys Val Phe
    690                 695                 700                 
Leu Ala Phe Val Ile Val Leu Leu Ala Leu Arg Leu Arg Arg Trp His
705                 710                 715                 720 
Lys Ser Arg Leu Leu Gln Ala Ser Gly Gly Gly Leu Ala Ser Thr Pro
                725                 730                 735     
Gly Ser His Phe Val Gly Ala Asp Gly Val Arg Ala Phe Leu Gln Thr
            740                 745                 750         
Tyr Ser His Glu Val Ser Leu Thr Ala Asp Ser Arg Lys Ser His Leu
        755                 760                 765             
Ile Phe Pro Gln Pro Asn Tyr Ala Asp Thr Leu Ile Ser Gln Glu Ser
    770                 775                 780                 
Cys Glu Lys Ser Glu Pro Leu Leu Ile Thr Gln Asp Leu Leu Glu Met
785                 790                 795                 800 
Lys Gly Asp Ser Asn Leu Leu Gln Val Ser Leu Phe Ile Ser Leu Ile
                805                 810                 815     
Ile Lys Asn Lys Tyr Glu Asn Val Val Ile Ile Lys Leu
            820                 825                 


<210> 1842
<211> 455
<212> PRT
<213> Homo sapiens

<400> 1842
Met Leu Ala Thr Arg Arg Leu Leu Gly Trp Ser Leu Pro Ala Arg Thr
 1               5                  10                  15      
Ala Pro Lys Lys Thr Ser Phe Gly Ser Leu Lys Asp Glu Asp Arg Ile
            20                  25                  30          
Phe Thr Asn Leu Tyr Gly Arg His Asp Trp Arg Leu Lys Gly Ser Leu
        35                  40                  45              
Ser Arg Gly Asp Trp Tyr Lys Thr Lys Glu Ile Leu Leu Lys Gly Pro
    50                  55                  60                  
Asp Trp Ile Leu Gly Glu Ile Lys Thr Ser Gly Leu Arg Gly Arg Gly
65                  70                  75                  80  
Gly Ala Gly Phe Pro Thr Gly Leu Lys Trp Ser Phe Met Asn Lys Pro
                85                  90                  95      
Ser Asp Gly Arg Pro Lys Tyr Leu Val Val Asn Ala Asp Glu Gly Glu
            100                 105                 110         
Pro Gly Thr Cys Lys Asp Arg Glu Ile Leu Arg His Asp Pro His Lys
        115                 120                 125             
Leu Leu Glu Gly Cys Leu Val Gly Gly Arg Ala Met Gly Ala Arg Ala
    130                 135                 140                 
Ala Tyr Ile Tyr Ile Arg Gly Glu Phe Tyr Asn Glu Ala Ser Asn Leu
145                 150                 155                 160 
Gln Val Ala Ile Arg Glu Ala Tyr Glu Ala Gly Leu Ile Gly Lys Asn
                165                 170                 175     
Ala Cys Gly Ser Gly Tyr Asp Phe Asp Val Phe Val Val Arg Gly Ala
            180                 185                 190         
Gly Ala Tyr Ile Cys Gly Glu Glu Thr Ala Leu Ile Glu Ser Ile Glu
        195                 200                 205             
Gly Lys Gln Gly Lys Pro Arg Leu Lys Pro Pro Phe Pro Ala Asp Val
    210                 215                 220                 
Gly Val Phe Gly Cys Pro Thr Thr Val Ala Asn Val Glu Thr Val Ala
225                 230                 235                 240 
Val Ser Pro Thr Ile Cys Arg Arg Gly Gly Thr Trp Phe Ala Gly Phe
                245                 250                 255     
Gly Arg Glu Arg Asn Ser Gly Thr Lys Leu Phe Asn Ile Ser Gly His
            260                 265                 270         
Val Asn His Pro Cys Thr Val Glu Glu Glu Met Ser Val Pro Leu Lys
        275                 280                 285             
Glu Leu Ile Glu Lys His Ala Gly Gly Val Thr Gly Gly Trp Asp Asn
    290                 295                 300                 
Leu Leu Ala Val Ile Pro Gly Gly Ser Ser Thr Pro Leu Ile Pro Lys
305                 310                 315                 320 
Ser Val Cys Glu Thr Val Leu Met Asp Phe Asp Ala Leu Val Gln Ala
                325                 330                 335     
Gln Thr Gly Leu Gly Thr Ala Ala Val Ile Val Met Asp Arg Ser Thr
            340                 345                 350         
Asp Ile Val Lys Ala Ile Ala Arg Leu Ile Glu Phe Tyr Lys His Glu
        355                 360                 365             
Ser Cys Gly Gln Cys Thr Pro Cys Arg Glu Gly Val Asp Trp Met Asn
    370                 375                 380                 
Lys Val Met Ala Arg Phe Val Arg Gly Asp Ala Arg Pro Ala Glu Ile
385                 390                 395                 400 
Asp Ser Leu Trp Glu Ile Ser Lys Gln Ile Glu Gly His Thr Ile Cys
                405                 410                 415     
Ala Leu Gly Asp Gly Ala Ala Trp Pro Val Gln Gly Leu Ile Arg His
            420                 425                 430         
Phe Arg Pro Glu Leu Glu Glu Arg Met Gln Arg Phe Ala Gln Gln His
        435                 440                 445             
Gln Ala Arg Gln Ala Ala Ser
    450                 455 


<210> 1843
<211> 255
<212> PRT
<213> Homo sapiens

<400> 1843
Met Ala Phe Arg Gln Ala Leu Gln Leu Ala Ala Cys Gly Leu Ala Gly
 1               5                  10                  15      
Gly Ser Ala Ala Val Leu Phe Ser Ala Val Ala Val Gly Lys Pro Arg
            20                  25                  30          
Ala Gly Gly Asp Ala Glu Pro Arg Pro Ala Glu Pro Pro Ala Trp Ala
        35                  40                  45              
Gly Gly Ala Arg Pro Gly Pro Gly Val Trp Asp Pro Asn Trp Asp Arg
    50                  55                  60                  
Arg Glu Pro Leu Ser Leu Ile Asn Val Arg Lys Arg Asn Val Glu Ser
65                  70                  75                  80  
Gly Glu Glu Glu Leu Ala Ser Lys Leu Asp His Tyr Lys Ala Lys Ala
                85                  90                  95      
Thr Arg His Ile Phe Leu Ile Arg His Ser Gln Tyr His Val Asp Gly
            100                 105                 110         
Ser Leu Glu Lys Asp Arg Thr Leu Thr Pro Leu Gly Arg Glu Gln Ala
        115                 120                 125             
Glu Leu Thr Gly Leu Arg Leu Ala Ser Leu Gly Leu Lys Phe Asn Lys
    130                 135                 140                 
Ile Val His Ser Ser Met Thr Arg Ala Ile Glu Thr Thr Asp Ile Ile
145                 150                 155                 160 
Ser Arg His Leu Pro Gly Val Cys Lys Val Ser Thr Asp Leu Leu Arg
                165                 170                 175     
Glu Gly Ala Pro Ile Glu Pro Asp Pro Pro Val Ser His Trp Lys Pro
            180                 185                 190         
Glu Ala Val Gln Tyr Tyr Glu Asp Gly Ala Arg Ile Glu Ala Ala Phe
        195                 200                 205             
Arg Asn Tyr Ile His Arg Ala Asp Ala Arg Gln Glu Glu Asp Ser Tyr
    210                 215                 220                 
Glu Ile Phe Ile Cys His Ala Asn Val Ile Arg Tyr Ile Val Cys Ser
225                 230                 235                 240 
Ile Pro Pro Leu Leu Ser Ala Gly Asp Phe Val Val Leu Gly Ser
                245                 250                 255 


<210> 1844
<211> 240
<212> PRT
<213> Homo sapiens

<400> 1844
Ile Val Leu Asn Gly His Trp Arg Thr His Thr Gly Glu Lys Pro Tyr
 1               5                  10                  15      
Thr Cys Phe Glu Cys Gly Arg Asn Phe Ser Leu Lys Ser Ala Leu Ser
            20                  25                  30          
Val His Gln Arg Ile His Ser Gly Glu Lys Pro Tyr Ala Cys Thr Glu
        35                  40                  45              
Cys Gly Gln Gly Phe Ile Thr Lys Ser Gln Leu Ile Arg His Gln Arg
    50                  55                  60                  
Thr His Thr Gly Glu Lys Pro Tyr Val Cys Gly Glu Cys Gly Arg Gly
65                  70                  75                  80  
Phe Ile Ala Gln Ser Thr Leu His Tyr His Arg Ser Thr His Ser Lys
                85                  90                  95      
Glu Lys Pro Tyr Val Cys Ser Gln Cys Gly Arg Gly Phe Cys Asp Lys
            100                 105                 110         
Ser Thr Leu Leu Ala His Glu Gln Thr His Ser Gly Glu Lys Pro Tyr
        115                 120                 125             
Val Cys Gly Glu Cys Gly Arg Gly Phe Gly Arg Lys Ile Leu Leu Asn
    130                 135                 140                 
Arg His Trp Arg Thr His Thr Gly Glu Lys Pro Tyr Ala Cys Ile Glu
145                 150                 155                 160 
Cys Gly Arg Asn Phe Ser His Lys Ser Thr Leu Ser Leu His Gln Arg
                165                 170                 175     
Ile His Ser Gly Glu Lys Pro Tyr Ala Cys Val Glu Cys Gly Gln Ser
            180                 185                 190         
Phe Arg Arg Lys Ser Gln Leu Ile Ile His Gln Lys Ile His Ser Gly
        195                 200                 205             
Lys Ser Phe Arg Gly Ala Arg Ser Glu Asp Val Ile Leu Ala Thr Ser
    210                 215                 220                 
Gln Pro Ser Ala Thr Pro Ala Glu Met Leu Arg Glu Lys Pro Cys Leu
225                 230                 235                 240 


<210> 1845
<211> 1712
<212> PRT
<213> Homo sapiens

<400> 1845
Met Ala Ser Gly Ser Arg Trp Arg Pro Thr Pro Pro Pro Leu Leu Leu
 1               5                  10                  15      
Leu Leu Leu Leu Ala Leu Ala Ala Arg Ala Asp Gly Leu Glu Phe Gly
            20                  25                  30          
Gly Gly Pro Gly Gln Trp Ala Arg Tyr Ala Arg Trp Ala Gly Ala Ala
        35                  40                  45              
Ser Ser Gly Glu Leu Ser Phe Ser Leu Arg Thr Asn Ala Thr Arg Ala
    50                  55                  60                  
Leu Leu Leu Tyr Leu Asp Asp Gly Gly Asp Cys Asp Phe Leu Glu Leu
65                  70                  75                  80  
Leu Leu Val Asp Gly Arg Leu Arg Leu Arg Phe Thr Leu Ser Cys Ala
                85                  90                  95      
Glu Pro Ala Thr Leu Gln Leu Asp Thr Pro Val Ala Asp Asp Arg Trp
            100                 105                 110         
His Met Val Leu Leu Thr Arg Asp Ala Arg Arg Thr Ala Leu Ala Val
        115                 120                 125             
Asp Gly Glu Ala Arg Ala Ala Glu Val Arg Ser Lys Arg Arg Glu Met
    130                 135                 140                 
Gln Val Ala Ser Asp Leu Phe Val Gly Gly Ile Pro Pro Asp Val Arg
145                 150                 155                 160 
Leu Ser Ala Leu Thr Leu Ser Thr Val Lys Tyr Glu Pro Pro Phe Arg
                165                 170                 175     
Gly Leu Leu Ala Asn Leu Lys Leu Gly Glu Arg Pro Pro Ala Leu Leu
            180                 185                 190         
Gly Ser Gln Gly Leu Arg Gly Ala Thr Ala Asp Pro Leu Cys Ala Pro
        195                 200                 205             
Ala Arg Asn Pro Cys Ala Asn Gly Gly Leu Cys Thr Val Leu Ala Pro
    210                 215                 220                 
Gly Glu Val Gly Cys Asp Cys Ser His Thr Gly Phe Gly Gly Lys Phe
225                 230                 235                 240 
Cys Ser Glu Glu Glu His Pro Met Glu Gly Pro Ala His Leu Thr Leu
                245                 250                 255     
Asn Ser Glu Val Gly Ser Leu Leu Phe Ser Glu Gly Gly Ala Gly Arg
            260                 265                 270         
Gly Gly Ala Gly Asp Val His Gln Pro Thr Lys Gly Lys Glu Glu Phe
        275                 280                 285             
Val Ala Thr Phe Lys Gly Asn Glu Phe Phe Cys Tyr Asp Leu Ser His
    290                 295                 300                 
Asn Pro Ile Gln Ser Ser Thr Asp Glu Ile Thr Leu Ala Phe Arg Thr
305                 310                 315                 320 
Leu Gln Arg Asn Gly Leu Met Leu His Thr Gly Lys Ser Ala Asp Tyr
                325                 330                 335     
Val Asn Leu Ser Leu Lys Ser Gly Ala Val Trp Leu Val Ile Asn Leu
            340                 345                 350         
Gly Ser Gly Ala Phe Glu Ala Leu Val Glu Pro Val Asn Gly Lys Phe
        355                 360                 365             
Asn Asp Asn Ala Trp His Asp Val Arg Val Thr Arg Asn Leu Arg Gln
    370                 375                 380                 
His Ala Gly Ile Gly His Ala Met Val Asn Lys Leu His Tyr Leu Val
385                 390                 395                 400 
Thr Ile Ser Val Asp Gly Ile Leu Thr Thr Thr Gly Tyr Thr Gln Glu
                405                 410                 415     
Asp Tyr Thr Met Leu Gly Ser Asp Asp Phe Phe Tyr Ile Gly Gly Ser
            420                 425                 430         
Pro Asn Thr Ala Asp Leu Pro Gly Ser Pro Val Ser Asn Asn Phe Met
        435                 440                 445             
Gly Cys Leu Lys Asp Val Val Tyr Lys Asn Asn Asp Phe Lys Leu Glu
    450                 455                 460                 
Leu Ser Arg Leu Ala Lys Glu Gly Asp Pro Lys Met Lys Leu Gln Gly
465                 470                 475                 480 
Asp Leu Ser Phe Arg Cys Glu Asp Val Ala Ala Leu Asp Pro Val Thr
                485                 490                 495     
Phe Glu Ser Pro Glu Ala Phe Val Ala Leu Pro Arg Trp Ser Ala Lys
            500                 505                 510         
Arg Thr Gly Ser Ile Ser Leu Asp Phe Arg Thr Thr Glu Pro Asn Gly
        515                 520                 525             
Leu Leu Leu Phe Ser Gln Gly Arg Arg Ala Gly Gly Gly Ala Gly Ser
    530                 535                 540                 
His Ser Ser Ala Gln Arg Ala Asp Tyr Phe Ala Met Glu Leu Leu Asp
545                 550                 555                 560 
Gly His Leu Tyr Leu Leu Leu Asp Met Gly Ser Gly Gly Ile Lys Leu
                565                 570                 575     
Arg Ala Ser Ser Arg Lys Val Asn Asp Gly Glu Trp Cys His Val Asp
            580                 585                 590         
Phe Gln Arg Asp Gly Arg Lys Gly Ser Ile Ser Val Asn Ser Arg Ser
        595                 600                 605             
Thr Pro Phe Leu Ala Thr Gly Asp Ser Glu Ile Leu Asp Leu Glu Ser
    610                 615                 620                 
Glu Leu Tyr Leu Gly Gly Leu Pro Glu Gly Gly Arg Val Asp Leu Pro
625                 630                 635                 640 
Leu Pro Pro Glu Val Trp Thr Ala Ala Leu Arg Ala Gly Tyr Val Gly
                645                 650                 655     
Cys Val Arg Asp Leu Phe Ile Asp Gly Arg Ser Arg Asp Leu Arg Gly
            660                 665                 670         
Leu Ala Glu Ala Gln Gly Ala Val Gly Val Ala Pro Phe Cys Ser Arg
        675                 680                 685             
Glu Thr Leu Lys Gln Cys Ala Ser Ala Pro Cys Arg Asn Gly Gly Val
    690                 695                 700                 
Cys Arg Glu Gly Trp Asn Arg Phe Ile Cys Asp Cys Ile Gly Thr Gly
705                 710                 715                 720 
Phe Leu Gly Arg Val Cys Glu Arg Glu Ala Thr Val Leu Ser Tyr Asp
                725                 730                 735     
Gly Ser Met Tyr Met Lys Ile Met Leu Pro Asn Ala Met His Thr Glu
            740                 745                 750         
Ala Glu Asp Val Ser Leu Arg Phe Met Ser Gln Arg Ala Tyr Gly Leu
        755                 760                 765             
Met Met Ala Thr Thr Ser Arg Glu Ser Ala Asp Thr Leu Arg Leu Glu
    770                 775                 780                 
Leu Asp Gly Gly Gln Met Lys Leu Thr Val Asn Leu Asp Cys Leu Arg
785                 790                 795                 800 
Val Gly Cys Ala Pro Ser Lys Gly Pro Glu Thr Leu Phe Ala Gly His
                805                 810                 815     
Lys Leu Asn Asp Asn Glu Trp His Thr Val Arg Val Val Arg Arg Gly
            820                 825                 830         
Lys Ser Leu Gln Leu Ser Val Asp Asn Val Thr Val Glu Gly Gln Met
        835                 840                 845             
Ala Gly Ala His Met Arg Leu Glu Phe His Asn Ile Glu Thr Gly Ile
    850                 855                 860                 
Met Thr Glu Arg Arg Phe Ile Ser Val Val Pro Ser Asn Phe Ile Gly
865                 870                 875                 880 
His Leu Ser Gly Leu Val Phe Asn Gly Gln Pro Tyr Met Asp Gln Cys
                885                 890                 895     
Lys Asp Gly Asp Ile Thr Tyr Cys Glu Leu Asn Ala Arg Phe Gly Leu
            900                 905                 910         
Arg Ala Ile Val Ala Asp Pro Val Thr Phe Lys Ser Arg Ser Ser Tyr
        915                 920                 925             
Leu Ala Leu Ala Thr Leu Gln Ala Tyr Ala Ser Met His Leu Phe Phe
    930                 935                 940                 
Gln Phe Lys Thr Thr Ala Pro Asp Gly Leu Leu Leu Phe Asn Ser Gly
945                 950                 955                 960 
Asn Gly Asn Asp Phe Ile Val Ile Glu Leu Val Lys Gly Tyr Ile His
                965                 970                 975     
Tyr Val Phe Asp Leu Gly Asn Gly Pro Ser Leu Met Lys Gly Asn Ser
            980                 985                 990         
Asp Lys Pro Val Asn Asp Asn Gln Trp His Asn Val Val Val Ser Arg
        995                 1000                1005            
Asp Pro Gly Asn Val His Thr Leu Lys Ile Asp Ser Arg Thr Val Thr
    1010                1015                1020                
Gln His Ser Asn Gly Ala Arg Asn Leu Asp Leu Lys Gly Glu Leu Tyr
1025                1030                1035                1040
Ile Gly Gly Leu Ser Lys Asn Met Phe Ser Asn Leu Pro Lys Leu Val
                1045                1050                1055    
Ala Ser Arg Asp Gly Phe Gln Gly Cys Leu Ala Ser Val Asp Leu Asn
            1060                1065                1070        
Gly Arg Leu Pro Asp Leu Ile Ala Asp Ala Leu His Arg Ile Gly Gln
        1075                1080                1085            
Val Glu Arg Gly Cys Asp Gly Pro Ser Thr Thr Cys Thr Glu Glu Ser
    1090                1095                1100                
Cys Ala Asn Gln Gly Val Cys Leu Gln Gln Trp Asp Gly Phe Thr Cys
1105                1110                1115                1120
Asp Cys Thr Met Thr Ser Tyr Gly Gly Pro Val Cys Asn Asp Pro Gly
                1125                1130                1135    
Thr Thr Tyr Ile Phe Gly Lys Gly Gly Ala Leu Ile Thr Tyr Thr Trp
            1140                1145                1150        
Pro Pro Asn Asp Arg Pro Ser Thr Arg Met Asp Arg Leu Ala Val Gly
        1155                1160                1165            
Phe Ser Thr His Gln Arg Ser Ala Val Leu Val Arg Val Asp Ser Ala
    1170                1175                1180                
Ser Gly Leu Gly Asp Tyr Leu Gln Leu His Ile Asp Gln Gly Thr Val
1185                1190                1195                1200
Gly Val Ile Phe Asn Val Gly Thr Asp Asp Ile Thr Ile Asp Glu Pro
                1205                1210                1215    
Asn Ala Ile Val Ser Asp Gly Lys Tyr His Val Val Arg Phe Thr Arg
            1220                1225                1230        
Ser Gly Gly Asn Ala Thr Leu Gln Val Asp Ser Trp Pro Val Asn Glu
        1235                1240                1245            
Arg Tyr Pro Ala Gly Asn Phe Asp Asn Glu Arg Leu Ala Ile Ala Arg
    1250                1255                1260                
Gln Arg Ile Pro Tyr Arg Leu Gly Arg Val Val Asp Glu Trp Leu Leu
1265                1270                1275                1280
Asp Lys Gly Arg Gln Leu Thr Ile Phe Asn Ser Gln Ala Ala Ile Lys
                1285                1290                1295    
Ile Gly Gly Arg Asp Gln Gly Arg Pro Phe Gln Gly Gln Val Ser Gly
            1300                1305                1310        
Leu Tyr Tyr Asn Gly Leu Lys Val Leu Ala Leu Ala Ala Glu Ser Asp
        1315                1320                1325            
Pro Asn Val Arg Thr Glu Gly His Leu Arg Leu Val Gly Glu Gly Pro
    1330                1335                1340                
Ser Val Leu Leu Ser Ala Glu Thr Thr Ala Thr Thr Leu Leu Ala Asp
1345                1350                1355                1360
Met Ala Thr Thr Ile Met Glu Thr Thr Thr Thr Met Ala Thr Thr Thr
                1365                1370                1375    
Thr Arg Arg Gly Arg Ser Pro Thr Leu Arg Asp Ser Thr Thr Gln Asn
            1380                1385                1390        
Thr Asp Asp Leu Leu Val Ala Ser Ala Glu Cys Pro Ser Asp Asp Glu
        1395                1400                1405            
Asp Leu Glu Glu Cys Glu Pro Ser Thr Gly Gly Glu Leu Ile Leu Pro
    1410                1415                1420                
Ile Ile Thr Glu Asp Ser Leu Asp Pro Pro Pro Val Ala Thr Arg Ser
1425                1430                1435                1440
Pro Phe Val Pro Pro Pro Pro Thr Phe Tyr Pro Phe Leu Thr Gly Val
                1445                1450                1455    
Gly Ala Thr Gln Asp Thr Leu Pro Pro Pro Ala Ala Arg Arg Pro Pro
            1460                1465                1470        
Ser Gly Gly Pro Cys Gln Ala Glu Arg Asp Asp Ser Asp Cys Glu Glu
        1475                1480                1485            
Pro Ile Glu Ala Ser Gly Phe Ala Ser Gly Glu Val Phe Asp Ser Ser
    1490                1495                1500                
Leu Pro Pro Thr Asp Asp Glu Asp Phe Tyr Thr Thr Phe Pro Leu Val
1505                1510                1515                1520
Thr Asp Arg Thr Thr Leu Leu Ser Pro Arg Lys Pro Ala Pro Arg Pro
                1525                1530                1535    
Asn Leu Arg Thr Asp Gly Ala Thr Gly Ala Pro Gly Val Leu Phe Ala
            1540                1545                1550        
Pro Ser Ala Pro Ala Pro Asn Leu Pro Ala Gly Lys Met Asn His Arg
        1555                1560                1565            
Asp Pro Leu Gln Pro Leu Leu Glu Asn Pro Pro Leu Gly Pro Gly Ala
    1570                1575                1580                
Pro Thr Ser Phe Glu Pro Arg Arg Pro Pro Pro Leu Arg Pro Gly Val
1585                1590                1595                1600
Thr Ser Ala Pro Gly Phe Pro His Leu Pro Thr Ala Asn Pro Thr Gly
                1605                1610                1615    
Pro Gly Glu Arg Gly Pro Pro Gly Ala Val Glu Val Ile Arg Glu Ser
            1620                1625                1630        
Ser Ser Thr Thr Gly Met Val Val Gly Ile Val Ala Ala Ala Ala Leu
        1635                1640                1645            
Cys Ile Leu Ile Leu Leu Tyr Ala Met Tyr Lys Tyr Arg Asn Arg Asp
    1650                1655                1660                
Glu Gly Ser Tyr Gln Val Asp Gln Ser Arg Asn Tyr Ile Ser Asn Ser
1665                1670                1675                1680
Ala Gln Ser Asn Gly Ala Val Val Lys Glu Lys Ala Pro Ala Ala Pro
                1685                1690                1695    
Lys Thr Pro Ser Lys Ala Lys Lys Asn Lys Asp Lys Glu Tyr Tyr Val
            1700                1705                1710        


<210> 1846
<211> 437
<212> PRT
<213> Homo sapiens

<400> 1846
Met Ala Ala Pro Ser Trp Arg Gly Ala Arg Leu Val Gln Ser Val Leu
 1               5                  10                  15      
Arg Val Trp Gln Val Gly Pro His Val Ala Arg Glu Arg Val Ile Pro
            20                  25                  30          
Phe Ser Ser Leu Leu Gly Phe Gln Arg Arg Cys Val Ser Cys Val Ala
        35                  40                  45              
Gly Ser Ala Phe Ser Gly Pro Arg Leu Ala Ser Ala Ser Arg Ser Asn
    50                  55                  60                  
Gly Gln Gly Ser Ala Leu Asp His Phe Leu Gly Phe Ser Gln Pro Asp
65                  70                  75                  80  
Ser Ser Val Thr Pro Cys Val Pro Ala Val Ser Met Asn Arg Asp Glu
                85                  90                  95      
Gln Asp Val Leu Leu Val His His Pro Asp Met Pro Glu Asn Ser Arg
            100                 105                 110         
Val Leu Arg Val Val Leu Leu Gly Ala Pro Asn Ala Gly Lys Ser Thr
        115                 120                 125             
Leu Ser Asn Gln Leu Leu Gly Arg Lys Val Phe Pro Val Ser Arg Lys
    130                 135                 140                 
Val His Thr Thr Arg Cys Gln Ala Leu Gly Val Ile Thr Glu Lys Glu
145                 150                 155                 160 
Thr Gln Val Ile Leu Leu Asp Thr Pro Gly Ile Ile Ser Pro Gly Lys
                165                 170                 175     
Gln Lys Arg His His Leu Glu Leu Ser Leu Leu Glu Asp Thr Trp Lys
            180                 185                 190         
Ser Met Glu Ser Ala Asp Leu Val Val Val Leu Val Asp Val Ser Asp
        195                 200                 205             
Lys Trp Thr Arg Asn Gln Leu Ser Pro Gln Leu Leu Arg Cys Leu Thr
    210                 215                 220                 
Lys Tyr Ser Gln Ile Pro Ser Val Leu Val Met Asn Lys Val Asp Cys
225                 230                 235                 240 
Leu Lys Gln Lys Ser Val Leu Leu Glu Leu Thr Ala Ala Leu Thr Glu
                245                 250                 255     
Gly Val Val Asn Gly Lys Lys Leu Lys Met Arg Gln Ala Phe His Ser
            260                 265                 270         
His Pro Gly Thr His Cys Pro Ser Pro Ala Val Lys Asp Pro Asn Thr
        275                 280                 285             
Gln Ser Val Gly Asn Pro Gln Arg Ile Gly Trp Pro His Phe Lys Glu
    290                 295                 300                 
Ile Phe Met Leu Ser Ala Leu Ser Gln Glu Asp Val Lys Thr Leu Lys
305                 310                 315                 320 
Gln Tyr Leu Leu Thr Gln Ala Gln Pro Gly Pro Trp Glu Tyr His Ser
                325                 330                 335     
Ala Val Leu Thr Ser Gln Thr Pro Glu Glu Ile Cys Ala Asn Ile Ile
            340                 345                 350         
Arg Glu Lys Leu Leu Glu His Leu Pro Gln Glu Val Pro Tyr Asn Val
        355                 360                 365             
Gln Gln Lys Thr Ala Val Trp Glu Glu Gly Pro Gly Gly Glu Leu Val
    370                 375                 380                 
Ile Gln Gln Lys Leu Leu Val Pro Lys Glu Ser Tyr Val Lys Leu Leu
385                 390                 395                 400 
Ile Gly Pro Lys Gly His Val Ile Ser Gln Ile Ala Gln Glu Ala Gly
                405                 410                 415     
His Asp Leu Met Asp Ile Phe Leu Cys Asp Val Asp Ile Arg Leu Ser
            420                 425                 430         
Val Lys Leu Leu Lys
        435         


<210> 1847
<211> 1253
<212> PRT
<213> Homo sapiens

<400> 1847
Met Leu Ser Trp Arg Leu Gln Thr Gly Pro Glu Lys Ala Glu Leu Gln
 1               5                  10                  15      
Glu Leu Asn Ala Arg Leu Tyr Asp Tyr Val Cys Arg Val Arg Glu Leu
            20                  25                  30          
Glu Arg Glu Asn Leu Leu Leu Glu Glu Glu Leu Arg Gly Arg Arg Gly
        35                  40                  45              
Arg Glu Gly Leu Trp Ala Glu Gly Gln Ala Arg Cys Ala Glu Glu Ala
    50                  55                  60                  
Arg Ser Leu Arg Gln Gln Leu Asp Glu Leu Ser Trp Ala Thr Ala Leu
65                  70                  75                  80  
Ala Glu Gly Glu Arg Asp Ala Leu Arg Arg Glu Leu Arg Glu Leu Gln
                85                  90                  95      
Arg Leu Asp Ala Glu Glu Arg Ala Ala Arg Gly Arg Leu Asp Ala Glu
            100                 105                 110         
Leu Gly Ala Gln Gln Arg Glu Leu Gln Glu Ala Leu Gly Ala Arg Ala
        115                 120                 125             
Ala Leu Glu Ala Leu Leu Gly Arg Leu Gln Ala Glu Arg Arg Gly Leu
    130                 135                 140                 
Asp Ala Ala His Glu Arg Asp Val Arg Glu Leu Arg Ala Arg Ala Ala
145                 150                 155                 160 
Ser Leu Thr Met His Phe Arg Ala Arg Ala Thr Gly Pro Ala Ala Pro
                165                 170                 175     
Pro Pro Arg Leu Arg Glu Val His Asp Ser Tyr Ala Leu Leu Val Ala
            180                 185                 190         
Glu Ser Trp Arg Glu Thr Val Gln Leu Tyr Glu Asp Glu Val Arg Glu
        195                 200                 205             
Leu Glu Glu Ala Leu Arg Arg Gly Gln Glu Ser Arg Leu Gln Ala Glu
    210                 215                 220                 
Glu Glu Thr Arg Leu Cys Ala Gln Glu Ala Glu Ala Leu Arg Arg Glu
225                 230                 235                 240 
Ala Leu Gly Leu Glu Gln Leu Arg Ala Arg Leu Glu Asp Ala Leu Leu
                245                 250                 255     
Arg Met Arg Glu Glu Tyr Gly Ile Gln Ala Glu Glu Arg Gln Arg Ala
            260                 265                 270         
Ile Asp Cys Leu Glu Asp Glu Lys Ala Thr Leu Thr Leu Ala Met Ala
        275                 280                 285             
Asp Trp Leu Arg Asp Tyr Gln Asp Leu Leu Gln Val Lys Thr Gly Leu
    290                 295                 300                 
Ser Leu Glu Val Ala Thr Tyr Arg Ala Leu Leu Glu Gly Glu Ser Asn
305                 310                 315                 320 
Pro Glu Ile Val Ile Trp Ala Glu His Val Glu Asn Met Pro Ser Glu
                325                 330                 335     
Phe Arg Asn Lys Ser Tyr His Tyr Thr Asp Ser Leu Leu Gln Arg Glu
            340                 345                 350         
Asn Glu Arg Asn Leu Phe Ser Arg Gln Lys Ala Pro Leu Ala Ser Phe
        355                 360                 365             
Asn His Ser Ser Ala Leu Tyr Ser Asn Leu Ser Gly His Arg Gly Ser
    370                 375                 380                 
Gln Thr Gly Thr Ser Ile Gly Gly Asp Ala Arg Arg Gly Phe Leu Gly
385                 390                 395                 400 
Ser Gly Tyr Ser Ser Ser Ala Thr Thr Gln Gln Glu Asn Ser Tyr Gly
                405                 410                 415     
Lys Ala Val Ser Ser Gln Thr Asn Val Arg Thr Phe Ser Pro Thr Tyr
            420                 425                 430         
Gly Leu Leu Arg Asn Thr Glu Ala Gln Val Lys Thr Phe Pro Asp Arg
        435                 440                 445             
Pro Lys Ala Gly Asp Thr Arg Glu Val Pro Val Tyr Ile Gly Glu Asp
    450                 455                 460                 
Ser Thr Ile Ala Arg Glu Ser Tyr Arg Asp Arg Arg Asp Lys Val Ala
465                 470                 475                 480 
Ala Gly Ala Ser Glu Ser Thr Arg Ser Asn Glu Arg Thr Val Ile Leu
                485                 490                 495     
Gly Lys Lys Thr Glu Val Lys Ala Thr Arg Glu Gln Glu Arg Asn Arg
            500                 505                 510         
Pro Glu Thr Ile Arg Thr Lys Pro Glu Glu Lys Met Phe Asp Ser Lys
        515                 520                 525             
Glu Lys Ala Ser Glu Glu Arg Asn Leu Arg Trp Glu Glu Leu Thr Lys
    530                 535                 540                 
Leu Asp Lys Glu Ala Arg Gln Arg Glu Ser Gln Gln Met Lys Glu Lys
545                 550                 555                 560 
Ala Lys Glu Lys Asp Ser Pro Lys Glu Lys Ser Val Arg Glu Arg Glu
                565                 570                 575     
Val Pro Ile Ser Leu Glu Val Ser Gln Asp Arg Arg Ala Glu Val Ser
            580                 585                 590         
Pro Lys Gly Leu Gln Thr Pro Val Lys Asp Ala Gly Gly Gly Thr Gly
        595                 600                 605             
Arg Glu Ala Glu Ala Arg Glu Leu Arg Phe Arg Leu Gly Thr Ser Asp
    610                 615                 620                 
Ala Thr Gly Ser Leu Gln Gly Asp Ser Met Thr Glu Thr Val Ala Glu
625                 630                 635                 640 
Asn Ile Val Thr Ser Ile Leu Lys Gln Phe Thr Gln Ser Pro Glu Thr
                645                 650                 655     
Glu Ala Ser Ala Asp Ser Phe Pro Asp Thr Lys Val Thr Tyr Val Asp
            660                 665                 670         
Arg Lys Glu Leu Pro Gly Glu Arg Lys Thr Lys Thr Glu Ile Val Val
        675                 680                 685             
Glu Ser Lys Leu Thr Glu Asp Val Asp Val Ser Asp Glu Ala Gly Leu
    690                 695                 700                 
Asp Tyr Leu Leu Ser Lys Asp Ile Lys Glu Val Gly Leu Lys Gly Lys
705                 710                 715                 720 
Ser Ala Glu Gln Met Ile Gly Asp Ile Ile Asn Leu Gly Leu Lys Gly
                725                 730                 735     
Arg Glu Gly Arg Ala Lys Val Val Asn Val Glu Ile Val Glu Glu Pro
            740                 745                 750         
Val Ser Tyr Val Ser Gly Glu Lys Pro Glu Glu Phe Ser Val Pro Phe
        755                 760                 765             
Lys Val Glu Glu Val Glu Asp Val Ser Pro Gly Pro Trp Gly Leu Val
    770                 775                 780                 
Lys Glu Glu Glu Gly Tyr Gly Glu Ser Asp Val Thr Phe Ser Val Asn
785                 790                 795                 800 
Gln His Arg Arg Thr Lys Gln Pro Gln Glu Asn Thr Thr His Val Glu
                805                 810                 815     
Glu Val Thr Glu Ala Gly Asp Ser Glu Gly Glu Gln Ser Tyr Phe Val
            820                 825                 830         
Ser Thr Pro Asp Glu His Pro Gly Gly His Asp Arg Asp Asp Gly Ser
        835                 840                 845             
Val Tyr Gly Gln Ile His Ile Glu Glu Glu Ser Thr Ile Arg Tyr Ser
    850                 855                 860                 
Trp Gln Asp Glu Ile Val Gln Gly Thr Arg Arg Arg Thr Gln Lys Asp
865                 870                 875                 880 
Gly Ala Val Gly Glu Lys Val Val Lys Pro Leu Asp Val Pro Ala Pro
                885                 890                 895     
Ser Leu Glu Gly Asp Leu Gly Ser Thr His Trp Lys Glu Gln Ala Arg
            900                 905                 910         
Ser Gly Glu Phe His Ala Glu Pro Thr Val Ile Glu Lys Glu Ile Lys
        915                 920                 925             
Ile Pro His Glu Phe His Thr Ser Met Lys Gly Ile Ser Ser Lys Glu
    930                 935                 940                 
Pro Arg Gln Gln Leu Val Glu Val Ile Gly Gln Leu Glu Glu Thr Leu
945                 950                 955                 960 
Pro Glu Arg Met Arg Glu Glu Leu Ser Ala Leu Thr Arg Glu Gly Gln
                965                 970                 975     
Gly Gly Pro Gly Ser Val Ser Val Asp Val Lys Lys Val Gln Gly Ala
            980                 985                 990         
Gly Gly Ser Ser Val Thr Leu Val Ala Glu Val Asn Val Ser Gln Thr
        995                 1000                1005            
Val Asp Ala Asp Arg Leu Asp Leu Glu Glu Leu Ser Lys Asp Glu Ala
    1010                1015                1020                
Ser Glu Met Glu Lys Ala Val Glu Ser Val Val Arg Glu Ser Leu Ser
1025                1030                1035                1040
Arg Gln Arg Ser Pro Ala Pro Gly Ser Pro Asp Glu Glu Gly Gly Ala
                1045                1050                1055    
Glu Ala Pro Ala Ala Gly Ile Arg Phe Arg Arg Trp Ala Thr Arg Glu
            1060                1065                1070        
Leu Tyr Ile Pro Ser Gly Glu Ser Glu Val Ala Gly Gly Ala Ser His
        1075                1080                1085            
Ser Ser Gly Gln Arg Thr Pro Gln Gly Pro Val Ser Ala Thr Val Glu
    1090                1095                1100                
Val Ser Ser Pro Thr Gly Phe Ala Gln Ser Gln Val Leu Glu Asp Val
1105                1110                1115                1120
Ser Gln Ala Ala Arg His Ile Lys Leu Gly Pro Ser Glu Val Trp Arg
                1125                1130                1135    
Thr Glu Arg Met Ser Tyr Glu Gly Pro Thr Ala Glu Val Val Glu Met
            1140                1145                1150        
Asp Val Ser Asn Val Glu Ala Ile Arg Ser Arg Thr Gln Glu Ala Gly
        1155                1160                1165            
Ala Leu Gly Val Ser Asp Arg Gly Ser Trp Arg Asp Ala Asp Ser Arg
    1170                1175                1180                
Asn Asp Gln Ala Val Gly Val Ser Phe Lys Ala Ser Ala Gly Glu Gly
1185                1190                1195                1200
Asp Gln Ala His Arg Glu Gln Gly Lys Glu Gln Ala Met Phe Asp Lys
                1205                1210                1215    
Lys Val Gln Leu Gln Arg Met Val Asp Gln Arg Ser Val Ile Ser Asp
            1220                1225                1230        
Glu Lys Lys Val Ala Leu Leu Tyr Leu Asp Asn Glu Glu Glu Glu Asn
        1235                1240                1245            
Asp Gly His Trp Phe
    1250            


<210> 1848
<211> 397
<212> PRT
<213> Homo sapiens

<400> 1848
Met Gln Ala Ser Val Pro Gly Pro Ser Glu Glu Pro Val Val Tyr Asn
 1               5                  10                  15      
Pro Thr Thr Ala Ala Phe Ile Cys Asp Ser Leu Val Asn Glu Lys Thr
            20                  25                  30          
Ile Gly Ser Pro Pro Asn Glu Phe Tyr Cys Ser Glu Asn Thr Ser Val
        35                  40                  45              
Pro Asn Glu Ser Asn Lys Ile Leu Val Asn Lys Asp Val Pro Gln Lys
    50                  55                  60                  
Pro Gly Gly Glu Thr Thr Pro Ser Val Thr Asp Leu Leu Asn Tyr Phe
65                  70                  75                  80  
Leu Ala Pro Glu Ile Leu Thr Gly Asp Asn Gln Tyr Tyr Cys Glu Asn
                85                  90                  95      
Cys Ala Ser Leu Gln Asn Ala Glu Lys Thr Met Gln Ile Thr Glu Glu
            100                 105                 110         
Pro Glu Tyr Leu Ile Leu Thr Leu Leu Arg Phe Ser Tyr Asp Gln Lys
        115                 120                 125             
Tyr His Val Arg Arg Lys Ile Leu Asp Asn Val Ser Leu Pro Leu Val
    130                 135                 140                 
Leu Glu Leu Pro Val Lys Arg Ile Thr Ser Phe Ser Ser Leu Ser Glu
145                 150                 155                 160 
Ser Trp Ser Val Asp Val Asp Phe Thr Asp Leu Ser Glu Asn Leu Ala
                165                 170                 175     
Lys Lys Leu Lys Pro Ser Gly Thr Asp Glu Ala Ser Cys Thr Lys Leu
            180                 185                 190         
Val Pro Tyr Leu Leu Ser Ser Val Val Val His Ser Gly Ile Ser Ser
        195                 200                 205             
Glu Ser Gly His Tyr Tyr Ser Tyr Ala Arg Asn Ile Thr Ser Thr Asp
    210                 215                 220                 
Ser Ser Tyr Gln Met Tyr His Gln Ser Glu Ala Leu Ala Leu Ala Ser
225                 230                 235                 240 
Ser Gln Ser His Leu Leu Gly Arg Asp Ser Pro Ser Ala Val Phe Glu
                245                 250                 255     
Gln Asp Leu Glu Asn Lys Glu Met Ser Lys Glu Trp Phe Leu Phe Asn
            260                 265                 270         
Asp Ser Arg Val Thr Phe Thr Ser Phe Gln Ser Val Gln Lys Ile Thr
        275                 280                 285             
Ser Arg Phe Pro Lys Asp Thr Ala Tyr Val Leu Leu Tyr Lys Lys Gln
    290                 295                 300                 
His Ser Thr Asn Gly Leu Ser Gly Asn Asn Pro Thr Ser Gly Leu Trp
305                 310                 315                 320 
Ile Asn Gly Asp Pro Pro Leu Gln Lys Glu Leu Met Asp Ala Ile Thr
                325                 330                 335     
Lys Asp Asn Lys Leu Tyr Leu Gln Glu Gln Glu Leu Asn Ala Arg Ala
            340                 345                 350         
Arg Ala Leu Gln Ala Ala Ser Ala Ser Cys Ser Phe Arg Pro Asn Gly
        355                 360                 365             
Phe Asp Asp Asn Asp Pro Pro Gly Ser Cys Gly Pro Thr Gly Gly Gly
    370                 375                 380                 
Gly Gly Gly Gly Phe Asn Thr Val Gly Arg Leu Val Phe
385                 390                 395         


<210> 1849
<211> 1274
<212> PRT
<213> Homo sapiens

<400> 1849
Met Gly His Leu Thr Leu Glu Asp Tyr Gln Ile Trp Ser Val Lys Asn
 1               5                  10                  15      
Val Leu Ala Asn Glu Phe Leu Asn Leu Leu Phe Gln Val Cys His Ile
            20                  25                  30          
Val Leu Gly Leu Arg Pro Ala Thr Pro Glu Glu Glu Gly Gln Ile Ile
        35                  40                  45              
Arg Gly Trp Leu Glu Arg Glu Ser Arg Tyr Gly Leu Gln Ala Gly His
    50                  55                  60                  
Asn Trp Phe Ile Ile Ser Met Gln Trp Trp Gln Gln Trp Lys Glu Tyr
65                  70                  75                  80  
Val Lys Tyr Asp Ala Asn Pro Val Val Ile Glu Pro Ser Ser Val Leu
                85                  90                  95      
Asn Gly Gly Lys Tyr Ser Phe Gly Thr Ala Ala His Pro Met Glu Gln
            100                 105                 110         
Val Glu Asp Arg Ile Gly Ser Ser Leu Ser Tyr Val Asn Thr Thr Glu
        115                 120                 125             
Glu Lys Phe Ser Asp Asn Ile Ser Thr Ala Ser Glu Ala Ser Glu Thr
    130                 135                 140                 
Ala Gly Ser Gly Phe Leu Tyr Ser Ala Thr Pro Gly Ala Asp Val Cys
145                 150                 155                 160 
Phe Ala Arg Gln His Asn Thr Ser Asp Asn Asn Asn Gln Cys Leu Leu
                165                 170                 175     
Gly Ala Asn Gly Asn Ile Leu Leu His Leu Asn Pro Gln Lys Pro Gly
            180                 185                 190         
Ala Ile Asp Asn Gln Pro Leu Val Thr Gln Glu Pro Val Lys Ala Thr
        195                 200                 205             
Ser Leu Thr Leu Glu Gly Gly Arg Leu Lys Arg Thr Pro Gln Leu Ile
    210                 215                 220                 
His Gly Arg Asp Tyr Glu Met Val Pro Glu Pro Val Trp Arg Ala Leu
225                 230                 235                 240 
Tyr His Trp Tyr Gly Ala Asn Leu Ala Leu Pro Arg Pro Val Ile Lys
                245                 250                 255     
Asn Ser Lys Thr Asp Ile Pro Glu Leu Glu Leu Phe Pro Arg Tyr Leu
            260                 265                 270         
Leu Phe Leu Arg Gln Gln Pro Ala Thr Arg Thr Gln Gln Ser Asn Ile
        275                 280                 285             
Trp Val Asn Met Gly Asn Val Pro Ser Pro Asn Ala Pro Leu Lys Arg
    290                 295                 300                 
Val Leu Ala Tyr Thr Gly Cys Phe Ser Arg Met Gln Thr Ile Lys Glu
305                 310                 315                 320 
Ile His Glu Tyr Leu Ser Gln Arg Leu Arg Ile Lys Glu Glu Asp Met
                325                 330                 335     
Arg Leu Trp Leu Tyr Asn Ser Glu Asn Tyr Leu Thr Leu Leu Asp Asp
            340                 345                 350         
Glu Asp His Lys Leu Glu Tyr Leu Lys Ile Gln Asp Glu Gln His Leu
        355                 360                 365             
Val Ile Glu Val Arg Asn Lys Asp Met Ser Trp Pro Glu Glu Met Ser
    370                 375                 380                 
Phe Ile Ala Asn Ser Ser Lys Ile Asp Arg His Lys Val Pro Thr Glu
385                 390                 395                 400 
Lys Gly Ala Thr Gly Leu Ser Asn Leu Gly Asn Thr Cys Phe Met Asn
                405                 410                 415     
Ser Ser Ile Gln Cys Val Ser Asn Thr Gln Pro Leu Thr Gln Tyr Phe
            420                 425                 430         
Ile Ser Gly Arg His Leu Tyr Glu Leu Asn Arg Thr Asn Pro Ile Gly
        435                 440                 445             
Met Lys Gly His Met Ala Lys Cys Tyr Gly Asp Leu Val Gln Glu Leu
    450                 455                 460                 
Trp Ser Gly Thr Gln Lys Asn Val Ala Pro Leu Lys Leu Arg Trp Thr
465                 470                 475                 480 
Ile Ala Lys Tyr Ala Pro Arg Phe Asn Gly Phe Gln Gln Gln Asp Ser
                485                 490                 495     
Gln Glu Leu Leu Ala Phe Leu Leu Asp Gly Leu His Glu Asp Leu Asn
            500                 505                 510         
Arg Val His Glu Lys Pro Tyr Val Glu Leu Lys Asp Ser Asp Gly Arg
        515                 520                 525             
Pro Asp Trp Glu Val Ala Ala Glu Ala Trp Asp Asn His Leu Arg Arg
    530                 535                 540                 
Asn Arg Ser Ile Val Val Asp Leu Phe Arg Gly Gln Leu Arg Ser Gln
545                 550                 555                 560 
Val Lys Cys Lys Thr Cys Gly His Ile Ser Val Arg Phe Asp Pro Phe
                565                 570                 575     
Asn Phe Leu Ser Leu Pro Leu Pro Met Asp Ser Tyr Met His Leu Glu
            580                 585                 590         
Ile Thr Val Ile Lys Leu Asp Gly Thr Thr Pro Val Arg Tyr Gly Leu
        595                 600                 605             
Arg Leu Asn Met Asp Glu Lys Tyr Thr Gly Leu Lys Lys Gln Leu Ser
    610                 615                 620                 
Asp Leu Cys Gly Leu Asn Ser Glu Gln Ile Leu Leu Ala Glu Val His
625                 630                 635                 640 
Gly Ser Asn Ile Lys Asn Phe Pro Gln Asp Asn Gln Lys Val Arg Leu
                645                 650                 655     
Ser Val Ser Gly Phe Leu Cys Ala Phe Glu Ile Pro Val Pro Val Ser
            660                 665                 670         
Pro Ile Ser Ala Ser Ser Pro Thr Gln Thr Asp Phe Ser Ser Ser Pro
        675                 680                 685             
Ser Thr Asn Glu Met Phe Thr Leu Thr Thr Asn Gly Asp Leu Pro Arg
    690                 695                 700                 
Pro Ile Phe Ile Pro Asn Gly Met Pro Asn Thr Val Val Pro Cys Gly
705                 710                 715                 720 
Thr Glu Lys Asn Phe Thr Asn Gly Met Val Asn Gly His Met Pro Ser
                725                 730                 735     
Leu Pro Asp Ser Pro Phe Thr Gly Tyr Ile Ile Ala Val His Arg Lys
            740                 745                 750         
Met Met Arg Thr Glu Leu Tyr Phe Leu Ser Ser Gln Lys Asn Arg Pro
        755                 760                 765             
Ser Leu Phe Gly Met Pro Leu Ile Val Pro Cys Thr Val His Thr Arg
    770                 775                 780                 
Lys Lys Asp Leu Tyr Asp Ala Val Trp Ile Gln Val Ser Arg Leu Ala
785                 790                 795                 800 
Ser Pro Leu Pro Pro Gln Glu Ala Ser Asn His Ala Gln Asp Cys Asp
                805                 810                 815     
Asp Ser Met Gly Tyr Gln Tyr Pro Phe Thr Leu Arg Val Val Gln Lys
            820                 825                 830         
Asp Gly Asn Ser Ser Ala Trp Cys Pro Trp Tyr Arg Phe Cys Arg Gly
        835                 840                 845             
Cys Lys Ile Asp Cys Gly Glu Asp Arg Ala Phe Ile Gly Asn Ala Tyr
    850                 855                 860                 
Ile Ala Val Asp Trp Asp Pro Thr Ala Leu His Leu Arg Tyr Gln Thr
865                 870                 875                 880 
Ser Gln Glu Arg Val Val Asp Glu His Glu Ser Val Glu Gln Ser Arg
                885                 890                 895     
Arg Ala Gln Ala Glu Pro Ile Asn Leu Asp Ser Cys Leu Arg Ala Phe
            900                 905                 910         
Thr Ser Glu Glu Glu Leu Gly Glu Asn Glu Met Tyr Tyr Cys Ser Lys
        915                 920                 925             
Cys Lys Thr His Cys Leu Ala Thr Lys Lys Leu Asp Leu Trp Arg Leu
    930                 935                 940                 
Pro Pro Ile Leu Ile Ile His Leu Lys Arg Phe Gln Phe Val Asn Gly
945                 950                 955                 960 
Arg Trp Ile Lys Ser Gln Lys Ile Val Lys Phe Pro Arg Glu Ser Phe
                965                 970                 975     
Asp Pro Ser Ala Phe Leu Val Pro Arg Asp Pro Ala Leu Cys Gln His
            980                 985                 990         
Lys Pro Leu Thr Pro Gln Gly Asp Glu Leu Ser Glu Pro Arg Ile Leu
        995                 1000                1005            
Ala Arg Glu Val Lys Lys Val Asp Ala Gln Ser Ser Ala Gly Glu Glu
    1010                1015                1020                
Asp Val Leu Leu Ser Lys Ser Pro Ser Ser Leu Ser Ala Asn Ile Ile
1025                1030                1035                1040
Ser Ser Pro Lys Gly Ser Pro Ser Ser Ser Arg Lys Ser Gly Thr Ser
                1045                1050                1055    
Cys Pro Ser Ser Lys Asn Ser Ser Pro Asn Ser Ser Pro Arg Thr Leu
            1060                1065                1070        
Gly Arg Ser Lys Gly Arg Leu Arg Leu Pro Gln Ile Gly Ser Lys Asn
        1075                1080                1085            
Lys Leu Ser Ser Ser Lys Glu Asn Leu Asp Ala Ser Lys Glu Asn Gly
    1090                1095                1100                
Ala Gly Gln Ile Cys Glu Leu Ala Asp Ala Leu Ser Arg Gly His Val
1105                1110                1115                1120
Leu Gly Gly Ser Gln Pro Glu Leu Val Thr Pro Gln Asp His Glu Val
                1125                1130                1135    
Ala Leu Ala Asn Gly Phe Leu Tyr Glu His Glu Ala Cys Gly Asn Gly
            1140                1145                1150        
Tyr Ser Asn Gly Gln Leu Gly Asn His Ser Glu Glu Asp Ser Thr Asp
        1155                1160                1165            
Asp Gln Arg Glu Asp Thr Arg Ile Lys Pro Ile Tyr Asn Leu Tyr Ala
    1170                1175                1180                
Ile Ser Cys His Ser Gly Ile Leu Gly Gly Gly His Tyr Val Thr Tyr
1185                1190                1195                1200
Ala Lys Asn Pro Asn Cys Lys Trp Tyr Cys Tyr Asn Asp Ser Ser Cys
                1205                1210                1215    
Lys Glu Leu His Pro Asp Glu Ile Asp Thr Asp Ser Ala Tyr Ile Leu
            1220                1225                1230        
Phe Tyr Glu Gln Gln Gly Ile Asp Tyr Ala Gln Phe Leu Pro Lys Thr
        1235                1240                1245            
Asp Gly Lys Lys Met Ala Asp Thr Ser Ser Met Asp Glu Asp Phe Glu
    1250                1255                1260                
Ser Asp Tyr Lys Lys Tyr Cys Val Leu Gln
1265                1270                


<210> 1850
<211> 839
<212> PRT
<213> Homo sapiens

<400> 1850
Met Ala Leu Thr Gln Gly Gln Val Thr Phe Arg Asp Val Ala Ile Glu
 1               5                  10                  15      
Phe Ser Gln Glu Glu Trp Thr Cys Leu Asp Pro Ala Gln Arg Thr Leu
            20                  25                  30          
Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg Asn Leu Ala Ser Leu Gly
        35                  40                  45              
Ile Ser Cys Phe Asp Leu Ser Ile Ile Ser Met Leu Glu Gln Gly Lys
    50                  55                  60                  
Glu Pro Phe Thr Leu Glu Ser Gln Val Gln Ile Ala Gly Asn Pro Asp
65                  70                  75                  80  
Gly Trp Glu Trp Ile Lys Ala Val Ile Thr Ala Leu Ser Ser Glu Phe
                85                  90                  95      
Val Met Lys Asp Leu Leu His Lys Gly Lys Ser Asn Thr Gly Glu Val
            100                 105                 110         
Phe Gln Thr Val Met Leu Glu Arg Gln Glu Ser Gln Asp Ile Glu Gly
        115                 120                 125             
Cys Ser Phe Arg Glu Val Gln Lys Asn Thr His Gly Leu Glu Tyr Gln
    130                 135                 140                 
Cys Arg Asp Ala Glu Gly Asn Tyr Lys Gly Val Leu Leu Thr Gln Glu
145                 150                 155                 160 
Gly Asn Leu Thr His Gly Arg Asp Glu His Asp Lys Arg Asp Ala Arg
                165                 170                 175     
Asn Lys Leu Ile Lys Asn Gln Leu Gly Leu Ser Leu Gln Ser His Leu
            180                 185                 190         
Pro Glu Leu Gln Leu Phe Gln Tyr Glu Gly Lys Ile Tyr Glu Cys Asn
        195                 200                 205             
Gln Val Glu Lys Ser Phe Asn Asn Asn Ser Ser Val Ser Pro Pro Gln
    210                 215                 220                 
Gln Met Pro Tyr Asn Val Lys Thr His Ile Ser Lys Lys Tyr Leu Lys
225                 230                 235                 240 
Asp Phe Ile Ser Ser Leu Leu Leu Thr Gln Gly Gln Lys Ala Asn Asn
                245                 250                 255     
Trp Gly Ser Pro Tyr Lys Ser Asp Gly Cys Gly Met Val Phe Pro Gln
            260                 265                 270         
Asn Ser His Leu Ala Ser His Gln Arg Ser His Thr Lys Glu Lys Pro
        275                 280                 285             
Tyr Lys Cys Tyr Glu Cys Gly Lys Ala Phe Arg Thr Arg Ser Asn Leu
    290                 295                 300                 
Thr Thr His Gln Val Ile His Thr Gly Glu Lys Arg Tyr Lys Cys Asn
305                 310                 315                 320 
Glu Cys Gly Lys Val Phe Ser Arg Asn Ser Gln Leu Ser Gln His Gln
                325                 330                 335     
Lys Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys
            340                 345                 350         
Val Phe Thr Gln Asn Ser His Leu Val Arg His Arg Gly Ile His Thr
        355                 360                 365             
Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Ala Phe Arg Ala
    370                 375                 380                 
Arg Ser Ser Leu Ala Ile His Gln Ala Thr His Ser Gly Glu Lys Pro
385                 390                 395                 400 
Tyr Lys Cys Asn Glu Cys Gly Lys Val Phe Thr Gln Asn Ser His Leu
                405                 410                 415     
Thr Asn His Trp Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asn
            420                 425                 430         
Glu Cys Gly Lys Ala Phe Gly Val Arg Ser Ser Leu Ala Ile His Leu
        435                 440                 445             
Val Ile His Thr Gly Glu Lys Pro Tyr Lys Cys His Glu Cys Gly Lys
    450                 455                 460                 
Val Phe Arg Arg Asn Ser His Leu Ala Arg His Gln Leu Ile His Thr
465                 470                 475                 480 
Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Ala Phe Arg Ala
                485                 490                 495     
His Ser Asn Leu Thr Thr His Gln Val Ile His Thr Gly Glu Lys Pro
            500                 505                 510         
Tyr Lys Cys Asn Glu Cys Gly Lys Val Phe Thr Gln Asn Ser His Leu
        515                 520                 525             
Ala Asn His Gln Arg Ile His Thr Gly Val Lys Pro Tyr Met Cys Asn
    530                 535                 540                 
Glu Cys Gly Lys Ala Phe Ser Val Tyr Ser Ser Leu Thr Thr His Gln
545                 550                 555                 560 
Val Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys
                565                 570                 575     
Val Phe Thr Gln Asn Ser His Leu Ala Arg His Arg Gly Ile His Thr
            580                 585                 590         
Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Val Phe Arg His
        595                 600                 605             
Asn Ser Tyr Leu Ser Arg His Gln Arg Ile His Thr Gly Glu Lys Pro
    610                 615                 620                 
Tyr Lys Tyr Asn Glu Tyr Gly Lys Ala Phe Ser Glu His Ser Asn Leu
625                 630                 635                 640 
Thr Thr His Gln Val Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asn
                645                 650                 655     
Glu Cys Gly Lys Val Phe Thr Gln Asn Ser His Leu Ala Arg His Arg
            660                 665                 670         
Arg Val His Thr Gly Gly Lys Pro Tyr Gln Cys Asn Glu Cys Gly Lys
        675                 680                 685             
Ala Phe Ser Gln Thr Ser Lys Leu Ala Arg His Gln Arg Val His Thr
    690                 695                 700                 
Gly Glu Lys Pro Tyr Glu Cys Asn Gln Cys Gly Lys Ala Phe Ser Val
705                 710                 715                 720 
Arg Ser Ser Leu Thr Thr His Gln Ala Ile His Thr Gly Lys Lys Pro
                725                 730                 735     
Tyr Lys Cys Asn Glu Cys Gly Lys Val Phe Thr Gln Asn Ser His Leu
            740                 745                 750         
Ala Arg His Arg Gly Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asn
        755                 760                 765             
Glu Cys Gly Lys Ala Phe Ser Gln Thr Ser Lys Leu Ala Arg His Gln
    770                 775                 780                 
Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Gly Lys Pro Phe Ser
785                 790                 795                 800 
Ile Cys Ser Ser Leu Thr Thr His Gln Thr Ile His Thr Gly Gly Lys
                805                 810                 815     
Pro Tyr Lys Cys Asn Val Trp Lys Val Leu Lys Ser Glu Phe Lys Pro
            820                 825                 830         
Cys Lys Pro Ser Gln Asn Ser
        835                 


<210> 1851
<211> 163
<212> PRT
<213> Homo sapiens

<400> 1851
Met Ala Ala Ala Val Val Leu Ala Ala Gly Leu Arg Ala Ala Arg Arg
 1               5                  10                  15      
Ala Val Ala Ala Thr Gly Val Arg Gly Gly Gln Val Arg Gly Ala Ala
            20                  25                  30          
Gly Val Thr Asp Gly Asn Glu Val Ala Lys Ala Gln Gln Ala Thr Pro
        35                  40                  45              
Gly Gly Ala Ala Pro Thr Ile Phe Ser Arg Ile Leu Asp Lys Ser Leu
    50                  55                  60                  
Pro Ala Asp Ile Leu Tyr Glu Asp Gln Gln Cys Leu Val Phe Arg Asp
65                  70                  75                  80  
Val Ala Pro Gln Ala Pro Val His Phe Leu Val Ile Pro Lys Lys Pro
                85                  90                  95      
Ile Pro Arg Ile Ser Gln Ala Glu Glu Glu Asp Gln Gln Leu Leu Gly
            100                 105                 110         
His Leu Leu Leu Val Ala Lys Gln Thr Ala Lys Ala Glu Gly Leu Gly
        115                 120                 125             
Asp Gly Tyr Arg Leu Val Ile Asn Asp Gly Lys Leu Gly Ala Gln Ser
    130                 135                 140                 
Val Tyr His Leu His Ile His Val Leu Gly Gly Arg Gln Leu Gln Trp
145                 150                 155                 160 
Pro Pro Gly
            


<210> 1852
<211> 176
<212> PRT
<213> Homo sapiens

<400> 1852
Met Ala Arg Val Leu Lys Ala Ala Ala Ala Asn Ala Val Gly Leu Phe
 1               5                  10                  15      
Ser Arg Leu Gln Ala Pro Ile Pro Thr Val Arg Ala Ser Ser Thr Ser
            20                  25                  30          
Gln Pro Leu Asp Gln Val Thr Gly Ser Val Trp Asn Leu Gly Arg Leu
        35                  40                  45              
Asn His Val Ala Ile Ala Val Pro Asp Leu Glu Lys Ala Ala Ala Phe
    50                  55                  60                  
Tyr Lys Asn Ile Leu Gly Ala Gln Val Ser Glu Ala Val Pro Leu Pro
65                  70                  75                  80  
Glu His Gly Val Ser Val Val Phe Val Asn Leu Gly Asn Thr Lys Met
                85                  90                  95      
Glu Leu Leu His Pro Leu Gly Arg Asp Ser Pro Ile Ala Gly Phe Leu
            100                 105                 110         
Gln Lys Asn Lys Ala Gly Gly Met His His Ile Cys Ile Glu Val Asp
        115                 120                 125             
Asn Ile Asn Ala Ala Val Met Asp Leu Lys Lys Lys Lys Ile Arg Ser
    130                 135                 140                 
Leu Ser Glu Glu Val Lys Ile Gly Ala His Gly Lys Pro Val Ile Phe
145                 150                 155                 160 
Leu His Pro Lys Asp Cys Gly Gly Val Leu Val Glu Leu Glu Gln Ala
                165                 170                 175     


<210> 1853
<211> 829
<212> PRT
<213> Homo sapiens

<400> 1853
Met Gly Cys Ala Pro Ser Ile His Ile Ser Glu Arg Leu Val Ala Glu
 1               5                  10                  15      
Asp Ala Pro Ser Pro Ala Ala Pro Pro Leu Ser Ser Gly Gly Pro Arg
            20                  25                  30          
Leu Pro Gln Gly Gln Lys Thr Ala Ala Leu Pro Arg Thr Arg Gly Ala
        35                  40                  45              
Gly Leu Leu Glu Ser Glu Val Arg Asp Gly Ser Gly Lys Lys Val Ala
    50                  55                  60                  
Val Ala Asp Val Gln Phe Gly Pro Met Arg Phe His Gln Asp Gln Leu
65                  70                  75                  80  
Gln Val Leu Leu Val Phe Thr Lys Glu Asp Asn Gln Cys Asn Gly Phe
                85                  90                  95      
Cys Arg Ala Cys Glu Lys Ala Gly Phe Lys Cys Thr Val Thr Lys Glu
            100                 105                 110         
Ala Gln Ala Val Leu Ala Cys Phe Leu Asp Lys His His Asp Ile Ile
        115                 120                 125             
Ile Ile Asp His Arg Asn Pro Arg Gln Leu Asp Ala Glu Ala Leu Cys
    130                 135                 140                 
Arg Ser Ile Arg Ser Ser Lys Leu Ser Glu Asn Thr Val Ile Val Gly
145                 150                 155                 160 
Val Val Arg Arg Val Asp Arg Glu Glu Leu Ser Val Met Pro Phe Ile
                165                 170                 175     
Ser Ala Gly Phe Thr Arg Arg Tyr Val Glu Asn Pro Asn Ile Met Ala
            180                 185                 190         
Cys Tyr Asn Glu Leu Leu Gln Leu Glu Phe Gly Glu Val Arg Ser Gln
        195                 200                 205             
Leu Lys Leu Arg Ala Cys Asn Ser Val Phe Thr Ala Leu Glu Asn Ser
    210                 215                 220                 
Glu Asp Ala Ile Glu Ile Thr Ser Glu Asp Arg Phe Ile Gln Tyr Ala
225                 230                 235                 240 
Asn Pro Ala Phe Glu Thr Thr Met Gly Tyr Gln Ser Gly Glu Leu Ile
                245                 250                 255     
Gly Lys Glu Leu Gly Glu Val Pro Ile Asn Glu Lys Lys Ala Asp Leu
            260                 265                 270         
Leu Asp Thr Ile Asn Ser Cys Ile Arg Ile Gly Lys Glu Trp Gln Gly
        275                 280                 285             
Ile Tyr Tyr Ala Lys Lys Lys Asn Gly Asp Asn Ile Gln Gln Asn Val
    290                 295                 300                 
Lys Ile Ile Pro Val Ile Gly Gln Gly Gly Lys Ile Arg His Tyr Val
305                 310                 315                 320 
Ser Ile Ile Arg Val Cys Asn Gly Asn Asn Lys Ala Glu Lys Ile Ser
                325                 330                 335     
Glu Cys Val Gln Ser Asp Thr Arg Thr Asp Asn Gln Thr Gly Lys His
            340                 345                 350         
Lys Asp Arg Arg Lys Gly Ser Leu Asp Val Lys Ala Val Ala Ser Arg
        355                 360                 365             
Ala Thr Glu Val Ser Ser Gln Arg Arg His Ser Ser Met Ala Arg Ile
    370                 375                 380                 
His Ser Met Thr Ile Glu Ala Pro Ile Thr Lys Val Ile Asn Val Ile
385                 390                 395                 400 
Asn Ala Ala Gln Glu Ser Ser Pro Met Pro Val Thr Glu Ala Leu Asp
                405                 410                 415     
Arg Val Leu Glu Ile Leu Arg Thr Thr Glu Leu Tyr Ser Pro Gln Phe
            420                 425                 430         
Gly Ala Lys Asp Asp Asp Pro His Ala Asn Asp Leu Val Gly Gly Leu
        435                 440                 445             
Met Ser Asp Gly Leu Arg Arg Leu Ser Gly Asn Glu Tyr Val Leu Ser
    450                 455                 460                 
Thr Lys Asn Thr Gln Met Val Ser Ser Asn Ile Ile Thr Pro Ile Ser
465                 470                 475                 480 
Leu Asp Asp Val Pro Pro Arg Ile Ala Arg Ala Met Glu Asn Glu Glu
                485                 490                 495     
Tyr Trp Asp Phe Asp Ile Phe Glu Leu Glu Ala Ala Thr His Asn Arg
            500                 505                 510         
Pro Leu Ile Tyr Leu Gly Leu Lys Met Phe Ala Arg Phe Gly Ile Cys
        515                 520                 525             
Glu Phe Leu His Cys Ser Glu Ser Thr Leu Arg Ser Trp Leu Gln Ile
    530                 535                 540                 
Ile Glu Ala Asn Tyr His Ser Ser Asn Pro Tyr His Asn Ser Thr His
545                 550                 555                 560 
Ser Ala Asp Val Leu His Ala Thr Ala Tyr Phe Leu Ser Lys Glu Arg
                565                 570                 575     
Ile Lys Glu Thr Leu Asp Pro Ile Asp Glu Val Ala Ala Leu Ile Ala
            580                 585                 590         
Ala Thr Ile His Asp Val Asp His Pro Gly Arg Thr Asn Ser Phe Leu
        595                 600                 605             
Cys Asn Ala Gly Ser Glu Leu Ala Ile Leu Tyr Asn Asp Thr Ala Val
    610                 615                 620                 
Leu Glu Ser His His Ala Ala Leu Ala Phe Gln Leu Thr Thr Gly Asp
625                 630                 635                 640 
Asp Lys Cys Asn Ile Phe Lys Asn Met Glu Arg Asn Asp Tyr Arg Thr
                645                 650                 655     
Leu Arg Gln Gly Ile Ile Asp Met Val Leu Ala Thr Glu Met Thr Lys
            660                 665                 670         
His Phe Glu His Val Asn Lys Phe Val Asn Ser Ile Asn Lys Pro Leu
        675                 680                 685             
Ala Thr Leu Glu Glu Asn Gly Glu Thr Asp Lys Asn Gln Glu Val Ile
    690                 695                 700                 
Asn Thr Met Leu Arg Thr Pro Glu Asn Arg Thr Leu Ile Lys Arg Met
705                 710                 715                 720 
Leu Ile Lys Cys Ala Asp Val Ser Asn Pro Cys Arg Pro Leu Gln Tyr
                725                 730                 735     
Cys Ile Glu Trp Ala Ala Arg Ile Ser Glu Glu Tyr Phe Ser Gln Thr
            740                 745                 750         
Asp Glu Glu Lys Gln Gln Gly Leu Pro Val Val Met Pro Val Phe Asp
        755                 760                 765             
Arg Asn Thr Cys Ser Ile Pro Lys Ser Gln Ile Ser Phe Ile Asp Tyr
    770                 775                 780                 
Phe Ile Thr Asp Met Phe Asp Ala Trp Asp Ala Phe Val Asp Leu Pro
785                 790                 795                 800 
Asp Leu Met Gln His Leu Asp Asn Asn Phe Lys Tyr Trp Lys Gly Leu
                805                 810                 815     
Asp Glu Met Lys Leu Arg Asn Leu Arg Pro Pro Pro Glu
            820                 825                 


<210> 1854
<211> 218
<212> PRT
<213> Homo sapiens

<400> 1854
Met Gly Thr Arg Asp Asp Glu Tyr Asp Tyr Leu Phe Lys Val Val Leu
 1               5                  10                  15      
Ile Gly Asp Ser Gly Val Gly Lys Ser Asn Leu Leu Ser Arg Phe Thr
            20                  25                  30          
Arg Asn Glu Phe Asn Leu Glu Ser Lys Ser Thr Ile Gly Val Glu Phe
        35                  40                  45              
Ala Thr Arg Ser Ile Gln Val Asp Gly Lys Thr Ile Lys Ala Gln Ile
    50                  55                  60                  
Trp Asp Thr Ala Gly Gln Glu Arg Tyr Arg Ala Ile Thr Ser Ala Tyr
65                  70                  75                  80  
Tyr Arg Gly Ala Val Gly Ala Leu Leu Val Tyr Asp Ile Ala Lys His
                85                  90                  95      
Leu Thr Tyr Glu Asn Val Glu Arg Trp Leu Lys Glu Leu Arg Asp His
            100                 105                 110         
Ala Asp Ser Asn Ile Val Ile Met Leu Val Gly Asn Lys Ser Asp Leu
        115                 120                 125             
Arg His Leu Arg Ala Val Pro Thr Asp Glu Ala Arg Ala Phe Ala Glu
    130                 135                 140                 
Lys Asn Asn Leu Ser Phe Ile Glu Thr Ser Ala Leu Asp Ser Thr Asn
145                 150                 155                 160 
Val Glu Glu Ala Phe Lys Asn Ile Leu Thr Glu Ile Tyr Arg Ile Val
                165                 170                 175     
Ser Gln Lys Gln Ile Ala Asp Arg Ala Ala His Asp Glu Ser Pro Gly
            180                 185                 190         
Asn Asn Val Val Asp Ile Ser Val Pro Pro Thr Thr Asp Gly Gln Lys
        195                 200                 205             
Pro Asn Lys Leu Gln Cys Cys Gln Asn Leu
    210                 215             


<210> 1855
<211> 619
<212> PRT
<213> Homo sapiens

<400> 1855
Met Ala Ala Ala Pro Pro Leu Ser Lys Ala Glu Tyr Leu Lys Arg Tyr
 1               5                  10                  15      
Leu Ser Gly Ala Asp Ala Gly Val Asp Arg Gly Ser Glu Ser Gly Arg
            20                  25                  30          
Lys Arg Arg Lys Lys Arg Pro Lys Pro Gly Gly Ala Gly Gly Lys Gly
        35                  40                  45              
Met Arg Ile Val Asp Asp Asp Val Ser Trp Thr Ala Ile Ser Thr Thr
    50                  55                  60                  
Lys Leu Glu Lys Glu Glu Glu Glu Asp Asp Gly Asp Leu Pro Val Val
65                  70                  75                  80  
Ala Glu Phe Val Asp Glu Arg Pro Glu Glu Val Lys Gln Met Glu Ala
                85                  90                  95      
Phe Arg Ser Ser Ala Lys Trp Lys Leu Leu Gly Gly His Asn Glu Asp
            100                 105                 110         
Leu Pro Ser Asn Arg His Phe Arg His Asp Thr Pro Asp Ser Ser Pro
        115                 120                 125             
Arg Arg Val Arg His Gly Thr Pro Asp Pro Ser Pro Arg Lys Asp Arg
    130                 135                 140                 
His Asp Thr Pro Asp Pro Ser Pro Arg Arg Ala Arg His Asp Thr Pro
145                 150                 155                 160 
Asp Pro Ser Pro Leu Arg Gly Ala Arg His Asp Ser Asp Thr Ser Pro
                165                 170                 175     
Pro Arg Arg Ile Arg His Asp Ser Ser Asp Thr Ser Pro Pro Arg Arg
            180                 185                 190         
Ala Arg His Asp Ser Pro Asp Pro Ser Pro Pro Arg Arg Pro Gln His
        195                 200                 205             
Asn Ser Ser Gly Ala Ser Pro Arg Arg Val Arg His Asp Ser Pro Asp
    210                 215                 220                 
Pro Ser Pro Pro Arg Arg Ala Arg His Gly Ser Ser Asp Ile Ser Ser
225                 230                 235                 240 
Pro Arg Arg Val His Asn Asn Ser Pro Asp Thr Ser Arg Arg Thr Leu
                245                 250                 255     
Gly Ser Ser Asp Thr Gln Gln Leu Arg Arg Ala Arg His Asp Ser Pro
            260                 265                 270         
Asp Leu Ala Pro Asn Val Thr Tyr Ser Leu Pro Arg Thr Lys Ser Gly
        275                 280                 285             
Lys Ala Pro Glu Arg Ala Ser Ser Lys Thr Ser Pro His Trp Lys Glu
    290                 295                 300                 
Ser Gly Ala Ser His Leu Ser Phe Pro Lys Asn Ser Lys Tyr Glu Tyr
305                 310                 315                 320 
Asp Pro Asp Ile Ser Pro Pro Arg Lys Lys Gln Ala Lys Ser His Phe
                325                 330                 335     
Gly Asp Lys Lys Gln Leu Asp Ser Lys Gly Asp Cys Gln Lys Ala Thr
            340                 345                 350         
Asp Ser Asp Leu Ser Ser Pro Arg His Lys Gln Ser Pro Gly His Gln
        355                 360                 365             
Asp Ser Asp Ser Asp Leu Ser Pro Pro Arg Asn Arg Pro Arg His Arg
    370                 375                 380                 
Ser Ser Asp Ser Asp Leu Ser Pro Pro Arg Arg Arg Gln Arg Thr Lys
385                 390                 395                 400 
Ser Ser Asp Ser Asp Leu Ser Pro Pro Arg Arg Ser Gln Pro Pro Gly
                405                 410                 415     
Lys Lys Ala Ala His Met Tyr Ser Gly Ala Lys Thr Gly Leu Val Leu
            420                 425                 430         
Thr Asp Ile Gln Arg Glu Gln Gln Glu Leu Lys Glu Gln Asp Gln Glu
        435                 440                 445             
Thr Met Ala Phe Glu Ala Glu Phe Gln Tyr Ala Glu Thr Val Phe Arg
    450                 455                 460                 
Asp Lys Ser Gly Arg Lys Arg Asn Leu Lys Leu Glu Arg Leu Glu Gln
465                 470                 475                 480 
Arg Arg Lys Ala Glu Lys Asp Ser Glu Arg Asp Glu Leu Tyr Ala Gln
                485                 490                 495     
Trp Gly Lys Gly Leu Ala Gln Ser Arg Gln Gln Gln Gln Asn Val Glu
            500                 505                 510         
Asp Ala Met Lys Glu Met Gln Lys Pro Leu Ala Arg Tyr Ile Asp Asp
        515                 520                 525             
Glu Asp Leu Asp Arg Met Leu Arg Glu Gln Glu Arg Glu Gly Asp Pro
    530                 535                 540                 
Met Ala Asn Phe Ile Lys Lys Asn Lys Ala Lys Glu Asn Lys Asn Lys
545                 550                 555                 560 
Lys Val Arg Pro Arg Tyr Ser Gly Pro Ala Pro Pro Pro Asn Arg Phe
                565                 570                 575     
Asn Ile Trp Pro Gly Tyr Arg Trp Asp Gly Val Asp Arg Ser Asn Gly
            580                 585                 590         
Phe Glu Gln Lys Arg Phe Ala Arg Leu Ala Ser Lys Lys Ala Val Glu
        595                 600                 605             
Glu Leu Ala Tyr Lys Trp Ser Val Glu Asp Met
    610                 615                 


<210> 1856
<211> 499
<212> PRT
<213> Homo sapiens

<400> 1856
Met Ser Phe Gly Ser Glu His Tyr Leu Cys Ser Ser Ser Ser Tyr Arg
 1               5                  10                  15      
Lys Val Phe Gly Asp Gly Ser Arg Leu Ser Ala Arg Leu Ser Gly Ala
            20                  25                  30          
Gly Gly Ala Gly Gly Phe Arg Ser Gln Ser Leu Ser Arg Ser Asn Val
        35                  40                  45              
Ala Ser Ser Ala Ala Cys Ser Ser Ala Ser Ser Leu Gly Leu Gly Leu
    50                  55                  60                  
Ala Tyr Arg Arg Pro Pro Ala Ser Asp Gly Leu Asp Leu Ser Gln Ala
65                  70                  75                  80  
Ala Ala Arg Thr Asn Glu Tyr Lys Ile Ile Arg Thr Asn Glu Lys Glu
                85                  90                  95      
Gln Leu Gln Gly Leu Asn Asp Arg Phe Ala Val Phe Ile Glu Lys Val
            100                 105                 110         
His Gln Leu Glu Thr Gln Asn Arg Ala Leu Glu Ala Glu Leu Ala Ala
        115                 120                 125             
Leu Arg Gln Arg His Ala Glu Pro Ser Arg Val Gly Glu Leu Phe Gln
    130                 135                 140                 
Arg Glu Leu Arg Asp Leu Arg Ala Gln Leu Glu Glu Ala Ser Ser Ala
145                 150                 155                 160 
Arg Ser Gln Ala Leu Leu Glu Arg Asp Gly Leu Ala Glu Glu Val Gln
                165                 170                 175     
Arg Leu Arg Ala Arg Cys Glu Glu Glu Ser Arg Gly Arg Glu Gly Ala
            180                 185                 190         
Glu Arg Ala Leu Lys Ala Gln Gln Arg Asp Val Asp Gly Ala Thr Leu
        195                 200                 205             
Ala Arg Leu Asp Leu Glu Lys Lys Val Glu Ser Leu Leu Asp Glu Leu
    210                 215                 220                 
Ala Phe Val Arg Gln Val His Asp Glu Glu Val Ala Glu Leu Leu Ala
225                 230                 235                 240 
Thr Leu Gln Ala Ser Ser Gln Ala Ala Ala Glu Val Asp Val Thr Val
                245                 250                 255     
Ala Lys Pro Asp Leu Thr Ser Ala Leu Arg Glu Ile Arg Ala Gln Tyr
            260                 265                 270         
Glu Ser Leu Ala Ala Lys Asn Leu Gln Ser Ala Glu Glu Trp Tyr Lys
        275                 280                 285             
Ser Lys Phe Ala Asn Leu Asn Glu Gln Ala Ala Arg Ser Thr Glu Ala
    290                 295                 300                 
Ile Arg Ala Ser Arg Glu Glu Ile His Glu Tyr Arg Arg Gln Leu Gln
305                 310                 315                 320 
Ala Arg Thr Ile Glu Ile Glu Gly Leu Arg Gly Ala Asn Glu Ser Leu
                325                 330                 335     
Glu Arg Gln Ile Leu Glu Leu Glu Glu Arg His Ser Ala Glu Val Ala
            340                 345                 350         
Gly Tyr Gln Asp Ser Ile Gly Gln Leu Glu Asn Asp Leu Arg Asn Thr
        355                 360                 365             
Lys Ser Glu Met Ala Arg His Leu Arg Glu Tyr Gln Asp Leu Leu Asn
    370                 375                 380                 
Val Lys Met Ala Leu Asp Ile Glu Ile Ala Ala Tyr Arg Lys Leu Leu
385                 390                 395                 400 
Glu Gly Glu Glu Thr Arg Phe Ser Thr Ser Gly Leu Ser Ile Ser Gly
                405                 410                 415     
Leu Asn Pro Leu Pro Asn Pro Ser Tyr Leu Leu Pro Pro Arg Ile Leu
            420                 425                 430         
Ser Ala Thr Thr Ser Lys Val Ser Ser Thr Gly Leu Ser Leu Lys Lys
        435                 440                 445             
Glu Glu Glu Glu Glu Glu Ala Ser Lys Val Ala Ser Lys Lys Thr Ser
    450                 455                 460                 
Gln Ile Gly Glu Ser Phe Glu Glu Ile Leu Glu Glu Thr Val Ile Ser
465                 470                 475                 480 
Thr Lys Lys Thr Glu Lys Ser Asn Ile Glu Glu Thr Thr Ile Ser Ser
                485                 490                 495     
Gln Lys Ile
            


<210> 1857
<211> 58
<212> PRT
<213> Homo sapiens

<400> 1857
Met Ala Gly Pro Glu Ser Asp Ala Gln Tyr Gln Phe Thr Gly Ile Lys
 1               5                  10                  15      
Lys Tyr Phe Asn Ser Tyr Thr Leu Thr Gly Arg Met Asn Cys Val Leu
            20                  25                  30          
Ala Thr Tyr Gly Ser Ile Ala Leu Ile Val Leu Tyr Phe Lys Leu Arg
        35                  40                  45              
Ser Lys Lys Thr Pro Ala Val Lys Ala Thr
    50                  55              


<210> 1858
<211> 712
<212> PRT
<213> Homo sapiens

<400> 1858
Met Ala Ala Ala Gly Leu Val Ala Val Ala Ala Ala Ala Glu Tyr Ser
 1               5                  10                  15      
Gly Thr Val Ala Ser Gly Gly Asn Leu Pro Gly Val His Cys Gly Pro
            20                  25                  30          
Ser Ser Gly Ala Gly Pro Gly Phe Gly Pro Gly Ser Trp Ser Arg Ser
        35                  40                  45              
Leu Asp Arg Ala Leu Glu Glu Ala Ala Val Thr Gly Val Leu Ser Leu
    50                  55                  60                  
Ser Gly Arg Lys Leu Arg Glu Phe Pro Arg Gly Ala Ala Asn His Asp
65                  70                  75                  80  
Leu Thr Asp Thr Thr Arg Ala Asp Leu Ser Arg Asn Arg Leu Ser Glu
                85                  90                  95      
Ile Pro Ile Glu Ala Cys His Phe Val Ser Leu Glu Asn Leu Asn Leu
            100                 105                 110         
Tyr Gln Asn Cys Ile Arg Tyr Ile Pro Glu Ala Ile Leu Asn Leu Gln
        115                 120                 125             
Ala Leu Thr Phe Leu Asn Ile Ser Arg Asn Gln Leu Ser Thr Leu Pro
    130                 135                 140                 
Val His Leu Cys Asn Leu Pro Leu Lys Val Leu Ile Ala Ser Asn Asn
145                 150                 155                 160 
Lys Leu Val Ser Leu Pro Glu Glu Ile Gly His Leu Arg His Leu Met
                165                 170                 175     
Glu Leu Asp Val Ser Cys Asn Glu Ile Gln Thr Ile Pro Ser Gln Ile
            180                 185                 190         
Gly Asn Leu Glu Ala Leu Arg Asp Leu Asn Val Arg Arg Asn His Leu
        195                 200                 205             
Val His Leu Pro Glu Glu Leu Ala Glu Leu Pro Leu Ile Arg Leu Asp
    210                 215                 220                 
Phe Ser Cys Asn Lys Ile Thr Thr Ile Pro Val Cys Tyr Arg Asn Leu
225                 230                 235                 240 
Arg His Leu Gln Thr Ile Thr Leu Asp Asn Asn Pro Leu Gln Ser Pro
                245                 250                 255     
Pro Ala Gln Ile Cys Ile Lys Gly Lys Val His Ile Phe Lys Tyr Leu
            260                 265                 270         
Asn Ile Gln Ala Cys Lys Ile Ala Pro Asp Leu Pro Asp Tyr Asp Arg
        275                 280                 285             
Arg Pro Leu Gly Phe Gly Ser Cys His Glu Glu Leu Tyr Ser Ser Arg
    290                 295                 300                 
Pro Tyr Gly Ala Leu Asp Ser Gly Phe Asn Ser Val Asp Ser Gly Asp
305                 310                 315                 320 
Lys Arg Trp Ser Gly Asn Glu Pro Thr Asp Glu Phe Ser Asp Leu Pro
                325                 330                 335     
Leu Arg Val Ala Glu Ile Thr Lys Glu Gln Arg Leu Arg Arg Glu Ser
            340                 345                 350         
Gln Tyr Gln Glu Asn Arg Gly Ser Leu Val Val Thr Asn Gly Gly Val
        355                 360                 365             
Glu His Asp Leu Asp Gln Ile Asp Tyr Ile Asp Ser Cys Thr Ala Glu
    370                 375                 380                 
Glu Glu Glu Ala Glu Val Arg Gln Pro Lys Gly Pro Asp Pro Asp Ser
385                 390                 395                 400 
Leu Ser Ser Gln Phe Met Ala Tyr Ile Glu Gln Arg Arg Ile Ser His
                405                 410                 415     
Glu Gly Ser Pro Val Lys Pro Val Ala Ile Arg Glu Phe Gln Lys Thr
            420                 425                 430         
Glu Asp Met Arg Arg Tyr Leu His Gln Asn Arg Val Pro Ala Glu Pro
        435                 440                 445             
Ser Ser Leu Leu Ser Leu Ser Ala Ser His Asn Gln Leu Ser His Thr
    450                 455                 460                 
Asp Leu Glu Leu His Gln Arg Arg Glu Gln Leu Val Glu Arg Thr Arg
465                 470                 475                 480 
Arg Glu Ala Gln Leu Ala Ala Leu Gln Tyr Glu Glu Glu Lys Ile Arg
                485                 490                 495     
Thr Lys Gln Ile Gln Arg Asp Ala Val Leu Asp Phe Val Lys Gln Lys
            500                 505                 510         
Ala Ser Gln Ser Pro Gln Lys Gln His Pro Leu Leu Asp Gly Val Asp
        515                 520                 525             
Gly Glu Cys Pro Phe Pro Ser Arg Arg Ser Gln His Thr Asp Asp Ser
    530                 535                 540                 
Ala Leu Cys Met Ser Leu Ser Gly Leu Asn Gln Val Gly Cys Ala Ala
545                 550                 555                 560 
Thr Leu Pro His Ser Ser Ala Phe Thr Pro Leu Lys Ser Asp Asp Arg
                565                 570                 575     
Pro Asn Ala Leu Leu Ser Ser Pro Ala Thr Glu Thr Val His His Ser
            580                 585                 590         
Pro Ala Tyr Ser Phe Pro Ala Ala Ile Gln Arg Asn Gln Pro Gln Arg
        595                 600                 605             
Pro Glu Ser Phe Leu Phe Arg Ala Gly Val Arg Ala Glu Thr Asn Lys
    610                 615                 620                 
Gly His Ala Ser Pro Leu Pro Pro Ser Ala Ala Pro Thr Thr Asp Ser
625                 630                 635                 640 
Thr Asp Ser Ile Thr Gly Gln Asn Ser Arg Gln Arg Glu Glu Glu Leu
                645                 650                 655     
Glu Leu Ile Asp Gln Leu Arg Lys His Ile Glu Tyr Arg Leu Lys Val
            660                 665                 670         
Ser Leu Pro Cys Asp Leu Gly Ala Ala Leu Thr Asp Gly Val Val Leu
        675                 680                 685             
Cys His Leu Ala Asn His Val Arg Pro Arg Ser Val Pro Ser Ile His
    690                 695                 700                 
Val Pro Ser Pro Ala Val Val Ser
705                 710         


<210> 1859
<211> 179
<212> PRT
<213> Homo sapiens

<400> 1859
Met Asp Lys Val Cys Ala Val Phe Gly Gly Ser Arg Gly Ile Gly Arg
 1               5                  10                  15      
Ala Val Ala Gln Leu Met Ala Arg Lys Gly Tyr Arg Leu Ala Val Ile
            20                  25                  30          
Ala Arg Asn Leu Glu Gly Ala Lys Ala Ala Ala Gly Asp Leu Gly Gly
        35                  40                  45              
Asp His Leu Ala Phe Ser Cys Asp Val Ala Lys Glu His Asp Val Gln
    50                  55                  60                  
Asn Thr Phe Glu Glu Met Glu Lys His Leu Gly Arg Val Asn Phe Leu
65                  70                  75                  80  
Val Asn Ala Ala Gly Ile Asn Arg Asp Gly Leu Leu Val Arg Thr Lys
                85                  90                  95      
Thr Glu Asp Met Val Ser Gln Leu His Thr Asn Leu Leu Gly Ser Met
            100                 105                 110         
Leu Thr Cys Lys Ala Ala Met Arg Thr Met Ile Gln Gln Gln Gly Gly
        115                 120                 125             
Ser Ile Val Asn Val Gly Ser Ile Val Gly Leu Lys Gly Asn Ser Gly
    130                 135                 140                 
Gln Ser Val Tyr Ser Ala Ser Lys Gly Gly Leu Val Gly Phe Ser Arg
145                 150                 155                 160 
Ala Leu Ala Lys Glu Val Ala Arg Lys Lys Ile Arg Val Asn Val Val
                165                 170                 175     
Ala Pro Gly
            


<210> 1860
<211> 797
<212> PRT
<213> Homo sapiens

<400> 1860
Met Ala Ser Cys Arg Ala Trp Asn Leu Arg Val Leu Val Ala Val Val
 1               5                  10                  15      
Cys Gly Leu Leu Thr Gly Ile Ile Leu Gly Leu Gly Ile Trp Arg Ile
            20                  25                  30          
Val Ile Arg Ile Gln Arg Gly Lys Ser Thr Ser Ser Ser Ser Thr Pro
        35                  40                  45              
Thr Glu Phe Cys Arg Asn Gly Gly Thr Trp Glu Asn Gly Arg Cys Ile
    50                  55                  60                  
Cys Thr Glu Glu Trp Lys Gly Leu Arg Cys Thr Ile Ala Asn Phe Cys
65                  70                  75                  80  
Glu Asn Ser Thr Tyr Met Gly Phe Thr Phe Ala Arg Ile Pro Val Gly
                85                  90                  95      
Arg Tyr Gly Pro Ser Leu Gln Thr Cys Gly Lys Asp Thr Pro Asn Ala
            100                 105                 110         
Gly Asn Pro Met Ala Val Arg Leu Cys Ser Leu Ser Leu Tyr Gly Glu
        115                 120                 125             
Ile Glu Leu Gln Lys Val Thr Ile Gly Asn Cys Asn Glu Asn Leu Glu
    130                 135                 140                 
Thr Leu Glu Lys Gln Val Glu Asp Val Thr Ala Pro Leu Asn Asn Ile
145                 150                 155                 160 
Ser Ser Glu Val Gln Ile Leu Thr Ser Asp Ala Asn Lys Leu Thr Ala
                165                 170                 175     
Glu Asn Ile Thr Ser Ala Thr Arg Val Val Gly Gln Ile Phe Asn Thr
            180                 185                 190         
Ser Arg Asn Ala Ser Pro Glu Ala Lys Lys Val Ala Ile Val Thr Val
        195                 200                 205             
Ser Gln Leu Leu Asp Ala Ser Glu Asp Ala Phe Gln Arg Val Ala Ala
    210                 215                 220                 
Thr Ala Asn Asp Asp Ala Leu Thr Thr Leu Ile Glu Gln Met Glu Thr
225                 230                 235                 240 
Tyr Ser Leu Ser Leu Gly Asn Gln Ser Val Val Glu Pro Asn Ile Ala
                245                 250                 255     
Ile Gln Ser Ala Asn Phe Ser Ser Glu Asn Ala Val Gly Pro Ser Asn
            260                 265                 270         
Val Arg Phe Ser Val Gln Lys Gly Ala Ser Ser Ser Leu Val Ser Ser
        275                 280                 285             
Ser Thr Phe Ile His Thr Asn Val Asp Gly Leu Asn Pro Asp Ala Gln
    290                 295                 300                 
Thr Glu Leu Gln Val Leu Leu Asn Met Thr Lys Asn Tyr Thr Lys Thr
305                 310                 315                 320 
Cys Gly Phe Val Val Tyr Gln Asn Asp Lys Leu Phe Gln Ser Lys Thr
                325                 330                 335     
Phe Thr Ala Lys Ser Asp Phe Ser Gln Lys Ile Ile Ser Ser Lys Thr
            340                 345                 350         
Asp Glu Asn Glu Gln Asp Gln Ser Ala Ser Val Asp Met Val Phe Ser
        355                 360                 365             
Pro Lys Tyr Asn Gln Lys Glu Phe Gln Leu Tyr Ser Tyr Ala Cys Val
    370                 375                 380                 
Tyr Trp Asn Leu Ser Ala Lys Asp Trp Asp Thr Tyr Gly Cys Gln Lys
385                 390                 395                 400 
Asp Lys Gly Thr Asp Gly Phe Leu Arg Cys Arg Cys Asn His Thr Thr
                405                 410                 415     
Asn Phe Ala Val Leu Met Thr Phe Lys Lys Asp Tyr Gln Tyr Pro Lys
            420                 425                 430         
Ser Leu Asp Ile Leu Ser Asn Val Gly Cys Ala Leu Ser Val Thr Gly
        435                 440                 445             
Leu Ala Leu Thr Val Ile Phe Gln Ile Val Thr Arg Lys Val Arg Lys
    450                 455                 460                 
Thr Ser Val Thr Trp Val Leu Val Asn Leu Cys Ile Ser Met Leu Ile
465                 470                 475                 480 
Phe Asn Leu Leu Phe Val Phe Gly Ile Glu Asn Ser Asn Lys Asn Leu
                485                 490                 495     
Gln Thr Ser Asp Gly Asp Ile Asn Asn Ile Asp Phe Asp Asn Asn Asp
            500                 505                 510         
Ile Pro Arg Thr Asp Thr Ile Asn Ile Pro Asn Pro Met Cys Thr Ala
        515                 520                 525             
Ile Ala Ala Leu Leu His Tyr Phe Leu Leu Val Thr Phe Thr Trp Asn
    530                 535                 540                 
Ala Leu Ser Ala Ala Gln Leu Tyr Tyr Leu Leu Ile Arg Thr Met Lys
545                 550                 555                 560 
Pro Leu Pro Arg His Phe Ile Leu Phe Ile Ser Leu Ile Gly Trp Gly
                565                 570                 575     
Val Pro Ala Ile Val Val Ala Ile Thr Val Gly Val Ile Tyr Ser Gln
            580                 585                 590         
Asn Gly Asn Asn Pro Gln Trp Glu Leu Asp Tyr Arg Gln Glu Lys Ile
        595                 600                 605             
Cys Trp Leu Ala Ile Pro Glu Pro Asn Gly Val Ile Lys Ser Pro Leu
    610                 615                 620                 
Leu Trp Ser Phe Ile Val Pro Val Thr Ile Ile Leu Ile Ser Asn Val
625                 630                 635                 640 
Val Met Phe Ile Thr Ile Ser Ile Lys Val Leu Trp Lys Asn Asn Gln
                645                 650                 655     
Asn Leu Thr Ser Thr Lys Lys Val Ser Ser Met Lys Lys Ile Val Ser
            660                 665                 670         
Thr Leu Ser Val Ala Val Val Phe Gly Ile Thr Trp Ile Leu Ala Tyr
        675                 680                 685             
Leu Met Leu Val Asn Asp Asp Ser Ile Arg Ile Val Phe Ser Tyr Ile
    690                 695                 700                 
Phe Cys Leu Phe Asn Thr Thr Gln Gly Leu Gln Ile Phe Ile Leu Tyr
705                 710                 715                 720 
Thr Val Arg Thr Lys Val Phe Gln Ser Glu Ala Ser Lys Val Leu Met
                725                 730                 735     
Leu Leu Ser Ser Ile Gly Arg Arg Lys Ser Leu Pro Ser Val Thr Arg
            740                 745                 750         
Pro Arg Leu Arg Val Lys Met Tyr Asn Phe Leu Arg Ser Leu Pro Thr
        755                 760                 765             
Leu His Glu Arg Phe Arg Leu Leu Glu Thr Ser Pro Ser Thr Glu Glu
    770                 775                 780                 
Ile Thr Leu Ser Glu Ser Asp Asn Ala Lys Glu Ser Ile
785                 790                 795         


<210> 1861
<211> 732
<212> PRT
<213> Homo sapiens

<400> 1861
Met Glu Arg Gly Gly Gly Gly Ser Gly Thr Gly Ser Arg Pro Glu Gly
 1               5                  10                  15      
Thr Ala Arg Gly Thr Ser Leu Pro Gly Lys Ile Ala Glu Pro Gly Ala
            20                  25                  30          
Val Arg Thr Ser Gln Pro Asn Tyr Arg Pro Gln Gly Met Glu Gly Phe
        35                  40                  45              
Leu Lys Ser Asp Glu Arg Gln Arg Leu Ala Lys Glu Arg Arg Glu Glu
    50                  55                  60                  
Arg Glu Lys Cys Leu Ala Ala Arg Glu Gln Gln Ile Leu Glu Lys Gln
65                  70                  75                  80  
Lys Arg Ala Arg Leu Gln Tyr Glu Lys Gln Met Glu Glu Arg Trp Arg
                85                  90                  95      
Lys Leu Glu Glu Gln Arg Gln Arg Glu Asp Gln Lys Arg Ala Ala Val
            100                 105                 110         
Glu Glu Lys Arg Lys Gln Lys Leu Arg Glu Glu Glu Glu Arg Leu Glu
        115                 120                 125             
Ala Met Met Arg Arg Ser Leu Glu Arg Thr Gln Gln Leu Glu Leu Lys
    130                 135                 140                 
Lys Lys Tyr Ser Trp Gly Ala Pro Leu Ala Ile Gly Pro Gly Gly His
145                 150                 155                 160 
Asp Ala Cys Asp Lys Leu Ser Thr Ser Thr Met Ser Leu Pro Lys Pro
                165                 170                 175     
Thr Glu Pro Pro Met Asn Lys Arg Leu Ser Ser Ser Thr Val Ala Ile
            180                 185                 190         
Ser Tyr Ser Pro Asp Arg Val Phe His Val Cys Pro Arg Leu Ala Pro
        195                 200                 205             
Leu Gly Pro Leu Asn Pro Ser Tyr Lys Ser Ser Pro Thr Arg Asn Ile
    210                 215                 220                 
Glu Lys Lys Lys Ala Thr Ser Thr Ser Thr Ser Gly Ala Gly Asp Val
225                 230                 235                 240 
Gly Lys Glu Ala Leu Ser Gly Gly Glu Ala Ser Leu Val Glu Lys Val
                245                 250                 255     
Lys Arg Gly Gln Arg Thr Ala Thr Ser Leu Pro Val Val Asn Phe Gly
            260                 265                 270         
Ser Pro Leu Arg Arg Cys Glu Phe Ser Gly Gly Ile Pro Lys Arg Pro
        275                 280                 285             
Ser Ser Pro Val Ile Ser Lys Thr Ala Thr Lys Ala Tyr Pro Gln Ser
    290                 295                 300                 
Pro Lys Thr Thr Lys Pro Pro Tyr Pro Gly Ser Pro Val Lys Tyr Arg
305                 310                 315                 320 
Leu Pro Ala Leu Ser Gly Gln Asp Met Pro Lys Arg Lys Ala Glu Lys
                325                 330                 335     
Glu Lys Ser Asn Lys Glu Arg Glu Gly Thr Leu Ala Gln Gln Ala Ala
            340                 345                 350         
Gly Pro Gln Gly Glu Glu Ala Leu Glu Lys His Val Val Asp Lys His
        355                 360                 365             
Ala Ser Glu Lys His Ala Ala Ala Ala Gly Gly Lys Ala Glu Asn Ser
    370                 375                 380                 
Ala Ala Leu Gly Lys Pro Thr Ala Gly Thr Thr Asp Ala Gly Glu Ala
385                 390                 395                 400 
Ala Lys Ile Leu Ala Glu Lys Arg Arg Gln Ala Arg Leu Gln Lys Glu
                405                 410                 415     
Gln Glu Glu Gln Glu Arg Val Glu Lys Glu Glu Gln Asp Arg Leu Glu
            420                 425                 430         
Arg Glu Glu Leu Lys Arg Lys Ala Glu Glu Glu Arg Leu Arg Leu Glu
        435                 440                 445             
Glu Glu Ala Arg Lys Gln Glu Glu Glu Arg Lys Arg Gln Glu Glu Glu
    450                 455                 460                 
Lys Lys Lys Gln Glu Gly Glu Glu Lys Arg Lys Ala Gly Glu Glu Ala
465                 470                 475                 480 
Lys Arg Lys Ala Glu Glu Glu Leu Leu Leu Lys Glu Lys Gln Glu Gln
                485                 490                 495     
Glu Lys Gln Glu Lys Ala Met Ile Glu Lys Gln Lys Glu Ala Ala Glu
            500                 505                 510         
Thr Lys Ala Arg Glu Val Ala Glu Gln Met Arg Leu Glu Arg Glu Gln
        515                 520                 525             
Ile Met Leu Gln Ile Glu Gln Glu Arg Leu Glu Arg Lys Lys Arg Ile
    530                 535                 540                 
Asp Glu Ile Met Lys Arg Thr Arg Lys Ser Asp Val Pro Pro Gln Val
545                 550                 555                 560 
Lys Lys Glu Asp Pro Lys Val Gly Val Gln Pro Ala Val Cys Val Glu
                565                 570                 575     
Lys Lys Thr Lys Leu Val Val Pro Asn Lys Met Glu Ile Asn Gly Leu
            580                 585                 590         
Asn Thr Cys Gln Glu Val Asn Gly Val Asp His Ala Ala Pro Glu Thr
        595                 600                 605             
Tyr Pro Gln Asp Ile Phe Ser Asn Gly Leu Lys Pro Ala Gly Gly Leu
    610                 615                 620                 
Ile His Leu Asp Ala Leu Asp Gly Lys Ser Asn Ser Leu Asp Asp Ser
625                 630                 635                 640 
Thr Glu Glu Val Gln Ser Met Asp Val Ser Pro Val Ser Lys Glu Glu
                645                 650                 655     
Leu Ile Ser Ile Pro Glu Phe Ser Pro Val Ser Glu Met Ile Pro Gly
            660                 665                 670         
Val Ser Leu Asp Gln Asn Gly Thr Gly Asn Ala Arg Ala Leu Gln Asp
        675                 680                 685             
Leu Leu Asp Phe Thr Gly Pro Pro Thr Phe Pro Lys Arg Ser Ser Glu
    690                 695                 700                 
Asn Leu Ser Leu Asp Asp Cys Asn Lys Asn Leu Ile Glu Gly Phe Asn
705                 710                 715                 720 
Ser Pro Gly Gln Glu Thr Pro Leu Asn Thr Phe Cys
                725                 730         


<210> 1862
<211> 330
<212> PRT
<213> Homo sapiens

<400> 1862
Met Pro Ala Ser Arg Glu Glu Gly Gly Gly Arg Gly Glu Gly Gly Ala
 1               5                  10                  15      
Tyr His His Arg Gln Pro His His His Phe His His Gly Gly His Arg
            20                  25                  30          
Gly Gly Ser Leu Leu Gln His Val Gly Gly Asp His Arg Gly His Ser
        35                  40                  45              
Glu Glu Gly Gly Asp Glu Gln Pro Gly Thr Pro Ala Pro Ala Leu Ser
    50                  55                  60                  
Glu Leu Lys Ala Val Ile Cys Trp Leu Gln Lys Gly Leu Pro Phe Ile
65                  70                  75                  80  
Leu Ile Leu Leu Ala Lys Leu Cys Phe Gln His Lys Leu Gly Ile Ala
                85                  90                  95      
Val Cys Ile Gly Met Ala Ser Thr Phe Ala Tyr Ala Asn Ser Thr Leu
            100                 105                 110         
Arg Glu Gln Val Ser Leu Lys Glu Lys Arg Ser Val Leu Val Ile Leu
        115                 120                 125             
Trp Ile Leu Ala Phe Leu Ala Gly Asn Thr Leu Tyr Val Leu Tyr Thr
    130                 135                 140                 
Phe Ser Ser Gln Gln Leu Tyr Asn Ser Leu Ile Phe Leu Lys Pro Asn
145                 150                 155                 160 
Leu Glu Met Leu Asp Phe Phe Asp Leu Leu Trp Ile Val Gly Ile Ala
                165                 170                 175     
Asp Phe Val Leu Lys Tyr Ile Thr Ile Ala Leu Lys Cys Leu Ile Val
            180                 185                 190         
Ala Leu Pro Lys Ile Ile Leu Ala Val Lys Ser Lys Gly Lys Phe Tyr
        195                 200                 205             
Leu Val Ile Glu Glu Leu Ser Gln Leu Phe Arg Ser Leu Val Pro Ile
    210                 215                 220                 
Gln Leu Trp Tyr Lys Tyr Ile Met Gly Asp Asp Ser Ser Asn Ser Tyr
225                 230                 235                 240 
Phe Leu Gly Gly Val Leu Ile Val Leu Tyr Ser Leu Cys Lys Ser Phe
                245                 250                 255     
Asp Ile Cys Gly Arg Val Gly Gly Val Arg Lys Ala Leu Lys Leu Leu
            260                 265                 270         
Cys Thr Ser Gln Asn Tyr Gly Val Arg Ala Thr Gly Gln Gln Cys Thr
        275                 280                 285             
Glu Ala Gly Asp Ile Cys Ala Ile Cys Gln Ala Glu Phe Arg Glu Pro
    290                 295                 300                 
Leu Ile Leu Leu Cys Gln Met Leu Leu Lys Gly His Lys Lys Leu Glu
305                 310                 315                 320 
Leu Glu Lys Ile Asp Glu Ser Ala Gly Val
                325                 330 


<210> 1863
<211> 373
<212> PRT
<213> Homo sapiens

<400> 1863
Met Tyr Arg Leu Leu Ser Ala Val Thr Ala Arg Ala Ala Ala Pro Gly
 1               5                  10                  15      
Gly Leu Ala Ser Ser Cys Gly Arg Arg Gly Val His Gln Arg Ala Gly
            20                  25                  30          
Leu Pro Pro Leu Gly His Gly Trp Val Gly Gly Leu Gly Leu Gly Leu
        35                  40                  45              
Gly Leu Ala Leu Gly Val Lys Leu Ala Gly Gly Leu Ser Gly Ala Ala
    50                  55                  60                  
Pro Ala Gln Ser Pro Ala Ala Pro Asp Pro Glu Ala Ser Pro Leu Ala
65                  70                  75                  80  
Glu Pro Pro Gln Glu Gln Ser Leu Ala Pro Trp Ser Pro Gln Thr Pro
                85                  90                  95      
Ala Pro Pro Cys Ser Arg Cys Phe Ala Arg Ala Ile Glu Ser Ser Arg
            100                 105                 110         
Asp Leu Leu His Arg Ile Lys Asp Glu Val Gly Ala Pro Gly Ile Val
        115                 120                 125             
Val Gly Val Ser Val Asp Gly Lys Glu Val Trp Ser Glu Gly Leu Gly
    130                 135                 140                 
Tyr Ala Asp Val Glu Asn Arg Val Pro Cys Lys Pro Glu Thr Val Met
145                 150                 155                 160 
Arg Ile Ala Ser Ile Ser Lys Ser Leu Thr Met Val Ala Leu Ala Lys
                165                 170                 175     
Leu Trp Glu Ala Gly Lys Leu Asp Leu Asp Ile Pro Val Gln His Tyr
            180                 185                 190         
Val Pro Glu Phe Pro Glu Lys Glu Tyr Glu Gly Glu Lys Val Ser Val
        195                 200                 205             
Thr Thr Arg Leu Leu Ile Ser His Leu Ser Gly Ile Arg His Tyr Glu
    210                 215                 220                 
Lys Asp Ile Lys Lys Val Lys Glu Glu Lys Ala Tyr Lys Ala Leu Lys
225                 230                 235                 240 
Met Met Lys Glu Asn Val Ala Phe Glu Gln Glu Lys Glu Gly Lys Ser
                245                 250                 255     
Asn Glu Lys Asn Asp Phe Thr Lys Phe Lys Thr Glu Gln Glu Asn Glu
            260                 265                 270         
Ala Lys Cys Arg Asn Ser Lys Pro Gly Lys Lys Lys Asn Asp Phe Glu
        275                 280                 285             
Gln Gly Glu Leu Tyr Leu Arg Glu Lys Phe Glu Asn Ser Ile Glu Ser
    290                 295                 300                 
Leu Arg Leu Phe Lys Asn Asp Pro Leu Phe Phe Lys Pro Gly Ser Gln
305                 310                 315                 320 
Phe Leu Tyr Ser Thr Phe Gly Tyr Thr Leu Leu Ala Ala Ile Val Glu
                325                 330                 335     
Arg Ala Ser Gly Cys Lys Tyr Leu Asp Tyr Met Gln Lys Ile Phe His
            340                 345                 350         
Asp Leu Asp Met Leu Thr Thr Val Gln Glu Glu Asn Glu Pro Val Ile
        355                 360                 365             
Tyr Asn Arg Ala Arg
    370             


<210> 1864
<211> 654
<212> PRT
<213> Homo sapiens

<400> 1864
Met Ser Leu Ala Ala Tyr Cys Val Ile Cys Cys Arg Arg Ile Gly Thr
 1               5                  10                  15      
Ser Thr Ser Pro Pro Lys Ser Gly Thr His Trp Arg Asp Ile Arg Asn
            20                  25                  30          
Ile Ile Lys Phe Thr Gly Ser Leu Ile Leu Gly Gly Ser Leu Phe Leu
        35                  40                  45              
Thr Tyr Glu Val Leu Ala Leu Lys Lys Ala Val Thr Leu Asp Thr Gln
    50                  55                  60                  
Val Val Glu Arg Glu Lys Met Lys Ser Tyr Ile Tyr Val His Thr Val
65                  70                  75                  80  
Ser Leu Asp Lys Gly Glu Asn His Gly Ile Ala Trp Gln Ala Arg Lys
                85                  90                  95      
Glu Leu His Lys Ala Val Arg Lys Val Leu Ala Thr Ser Ala Lys Ile
            100                 105                 110         
Leu Arg Asn Pro Phe Ala Asp Pro Phe Ser Thr Val Asp Ile Glu Asp
        115                 120                 125             
His Glu Cys Ala Val Trp Leu Leu Leu Arg Lys Ser Lys Ser Asp Asp
    130                 135                 140                 
Lys Thr Thr Arg Leu Glu Ala Val Arg Glu Met Ser Glu Thr His His
145                 150                 155                 160 
Trp His Asp Tyr Gln Tyr Arg Ile Ile Ala Gln Ala Cys Asp Pro Lys
                165                 170                 175     
Thr Leu Ile Gly Leu Ala Arg Ser Glu Glu Ser Asp Leu Arg Phe Phe
            180                 185                 190         
Leu Leu Pro Pro Pro Leu Pro Ser Leu Lys Glu Asp Ser Ser Thr Glu
        195                 200                 205             
Glu Glu Leu Arg Gln Leu Leu Ala Ser Leu Pro Gln Thr Glu Leu Asp
    210                 215                 220                 
Glu Cys Ile Gln Tyr Phe Thr Ser Leu Ala Leu Ser Glu Ser Ser Gln
225                 230                 235                 240 
Ser Leu Ala Ala Gln Lys Gly Gly Leu Trp Cys Phe Gly Gly Asn Gly
                245                 250                 255     
Leu Pro Tyr Ala Glu Ser Phe Gly Glu Val Pro Ser Ala Thr Val Glu
            260                 265                 270         
Met Phe Cys Leu Glu Ala Ile Val Lys His Ser Glu Ile Ser Thr His
        275                 280                 285             
Cys Asp Lys Ile Glu Ala Asn Gly Gly Leu Gln Leu Leu Gln Arg Leu
    290                 295                 300                 
Tyr Arg Leu His Lys Asp Cys Pro Lys Val Gln Arg Asn Ile Met Arg
305                 310                 315                 320 
Val Ile Gly Asn Met Ala Leu Asn Glu His Leu His Ser Ser Ile Val
                325                 330                 335     
Arg Ser Gly Trp Val Ser Ile Met Ala Glu Ala Met Lys Ser Pro His
            340                 345                 350         
Ile Met Glu Ser Ser His Ala Ala Arg Ile Leu Ala Asn Leu Asp Arg
        355                 360                 365             
Glu Thr Val Gln Glu Lys Tyr Gln Asp Gly Val Tyr Val Leu His Pro
    370                 375                 380                 
Gln Tyr Arg Thr Ser Gln Pro Ile Lys Ala Asp Val Leu Phe Ile His
385                 390                 395                 400 
Gly Leu Met Gly Ala Ala Phe Lys Thr Trp Arg Gln Gln Asp Ser Glu
                405                 410                 415     
Gln Ala Val Ile Glu Lys Pro Met Glu Asp Glu Asp Arg Tyr Thr Thr
            420                 425                 430         
Cys Trp Pro Lys Thr Trp Leu Ala Lys Asp Cys Pro Ala Leu Arg Ile
        435                 440                 445             
Ile Ser Val Glu Tyr Asp Thr Ser Leu Ser Asp Trp Arg Ala Arg Cys
    450                 455                 460                 
Pro Met Glu Arg Lys Ser Ile Ala Phe Arg Ser Asn Glu Leu Leu Arg
465                 470                 475                 480 
Lys Leu Arg Ala Ala Gly Val Gly Asp Arg Pro Val Val Trp Ile Ser
                485                 490                 495     
His Ser Met Gly Gly Leu Leu Val Lys Lys Met Leu Leu Glu Ala Ser
            500                 505                 510         
Thr Lys Pro Glu Met Ser Thr Val Ile Asn Asn Thr Arg Gly Ile Ile
        515                 520                 525             
Phe Tyr Ser Val Pro His His Gly Ser Arg Leu Ala Glu Tyr Ser Val
    530                 535                 540                 
Asn Ile Arg Tyr Leu Leu Phe Pro Ser Leu Glu Val Lys Glu Leu Ser
545                 550                 555                 560 
Lys Asp Ser Pro Ala Leu Lys Thr Leu Gln Asp Asp Phe Leu Glu Phe
                565                 570                 575     
Ala Lys Asp Lys Asn Phe Gln Val Leu Asn Phe Val Glu Thr Leu Pro
            580                 585                 590         
Thr Tyr Ile Gly Ser Met Ile Lys Leu His Val Val Pro Val Glu Ser
        595                 600                 605             
Ala Asp Leu Gly Ile Gly Asp Leu Ile Pro Val Asp Val Asn His Leu
    610                 615                 620                 
Asn Ile Cys Lys Pro Lys Lys Lys Asp Ala Phe Leu Tyr Gln Arg Thr
625                 630                 635                 640 
Leu Gln Phe Ile Arg Glu Ala Leu Ala Lys Asp Leu Glu Asn
                645                 650                 


<210> 1865
<211> 422
<212> PRT
<213> Homo sapiens

<400> 1865
Met Phe Ser Asn Ser Asp Glu Ala Val Ile Asn Lys Lys Leu Pro Lys
 1               5                  10                  15      
Glu Leu Leu Leu Arg Ile Phe Ser Phe Leu Asp Val Val Thr Leu Cys
            20                  25                  30          
Arg Cys Ala Gln Val Ser Arg Ala Trp Asn Val Leu Ala Leu Asp Gly
        35                  40                  45              
Ser Asn Trp Gln Arg Ile Asp Leu Phe Asp Phe Gln Arg Asp Ile Glu
    50                  55                  60                  
Gly Arg Val Val Glu Asn Ile Ser Lys Arg Cys Gly Gly Phe Leu Arg
65                  70                  75                  80  
Lys Leu Ser Leu Arg Gly Cys Leu Gly Val Gly Asp Asn Ala Leu Arg
                85                  90                  95      
Thr Phe Ala Gln Asn Cys Arg Asn Ile Glu Val Leu Asn Leu Asn Gly
            100                 105                 110         
Cys Thr Lys Thr Thr Asp Ala Thr Cys Thr Ser Leu Ser Lys Phe Cys
        115                 120                 125             
Ser Lys Leu Arg His Leu Asp Leu Ala Ser Cys Thr Ser Ile Thr Asn
    130                 135                 140                 
Met Ser Leu Lys Ala Leu Ser Glu Gly Cys Pro Leu Leu Glu Gln Leu
145                 150                 155                 160 
Asn Ile Ser Trp Cys Asp Gln Val Thr Lys Asp Gly Ile Gln Ala Leu
                165                 170                 175     
Val Arg Gly Cys Gly Gly Leu Lys Ala Leu Phe Leu Lys Gly Cys Thr
            180                 185                 190         
Gln Leu Glu Asp Glu Ala Leu Lys Tyr Ile Gly Ala His Cys Pro Glu
        195                 200                 205             
Leu Val Thr Leu Asn Leu Gln Thr Cys Leu Gln Ile Thr Asp Glu Gly
    210                 215                 220                 
Leu Ile Thr Ile Cys Arg Gly Cys His Lys Leu Gln Ser Leu Cys Ala
225                 230                 235                 240 
Ser Gly Cys Ser Asn Ile Thr Asp Ala Ile Leu Asn Ala Leu Gly Gln
                245                 250                 255     
Asn Cys Pro Arg Leu Arg Ile Leu Glu Val Ala Arg Cys Ser Gln Leu
            260                 265                 270         
Thr Asp Val Gly Phe Thr Thr Leu Ala Arg Asn Cys His Glu Leu Glu
        275                 280                 285             
Lys Met Asp Leu Glu Glu Cys Val Gln Ile Thr Asp Ser Thr Leu Ile
    290                 295                 300                 
Gln Leu Ser Ile His Cys Pro Arg Leu Gln Val Leu Ser Leu Ser His
305                 310                 315                 320 
Cys Glu Leu Ile Thr Asp Asp Gly Ile Arg His Leu Gly Asn Gly Ala
                325                 330                 335     
Cys Ala His Asp Gln Leu Glu Val Ile Glu Leu Asp Asn Cys Pro Leu
            340                 345                 350         
Ile Thr Asp Ala Ser Leu Glu His Leu Lys Ser Cys His Ser Leu Glu
        355                 360                 365             
Arg Ile Glu Leu Tyr Asp Cys Gln Gln Ile Thr Arg Ala Gly Ile Lys
    370                 375                 380                 
Arg Leu Arg Thr His Leu Pro Asn Ile Lys Val His Ala Tyr Phe Ala
385                 390                 395                 400 
Pro Val Thr Pro Pro Pro Ser Val Gly Gly Ser Arg Gln Arg Phe Cys
                405                 410                 415     
Arg Cys Cys Ile Ile Leu
            420         


<210> 1866
<211> 538
<212> PRT
<213> Homo sapiens

<400> 1866
Met Leu Gln Ile Asn Gln Met Phe Ser Val Gln Leu Ser Leu Gly Glu
 1               5                  10                  15      
Gln Thr Trp Glu Ser Glu Gly Ser Ser Ile Lys Lys Ala Gln Gln Ala
            20                  25                  30          
Val Ala Asn Lys Ala Leu Thr Glu Ser Thr Leu Pro Lys Pro Val Gln
        35                  40                  45              
Lys Pro Pro Lys Ser Asn Val Asn Asn Asn Pro Gly Ser Ile Thr Pro
    50                  55                  60                  
Thr Val Glu Leu Asn Gly Leu Ala Met Lys Arg Gly Glu Pro Ala Ile
65                  70                  75                  80  
Tyr Arg Pro Leu Asp Pro Lys Pro Phe Pro Asn Tyr Arg Ala Asn Tyr
                85                  90                  95      
Asn Phe Arg Gly Met Tyr Asn Gln Arg Tyr His Cys Pro Val Pro Lys
            100                 105                 110         
Ile Phe Tyr Val Gln Leu Thr Val Gly Asn Asn Glu Phe Phe Gly Glu
        115                 120                 125             
Gly Lys Thr Arg Gln Ala Ala Arg His Asn Ala Ala Met Lys Ala Leu
    130                 135                 140                 
Gln Ala Leu Gln Asn Glu Pro Ile Pro Glu Arg Ser Pro Gln Asn Gly
145                 150                 155                 160 
Glu Ser Gly Lys Asp Met Asp Asp Asp Lys Asp Ala Asn Lys Ser Glu
                165                 170                 175     
Ile Ser Leu Val Phe Glu Ile Ala Leu Lys Arg Asn Met Pro Val Ser
            180                 185                 190         
Phe Glu Val Ile Lys Glu Ser Gly Pro Pro His Met Lys Ser Phe Val
        195                 200                 205             
Thr Arg Val Ser Val Gly Glu Phe Ser Ala Glu Gly Glu Gly Asn Ser
    210                 215                 220                 
Lys Lys Leu Ser Lys Lys Arg Ala Ala Thr Thr Val Leu Gln Glu Leu
225                 230                 235                 240 
Lys Lys Leu Pro Pro Leu Pro Val Val Glu Lys Pro Lys Leu Phe Phe
                245                 250                 255     
Lys Lys Arg Pro Lys Thr Ile Val Lys Ala Gly Pro Glu Tyr Gly Gln
            260                 265                 270         
Gly Met Asn Pro Ile Ser Arg Leu Ala Gln Ile Gln Gln Ala Lys Lys
        275                 280                 285             
Glu Lys Glu Pro Asp Tyr Val Leu Leu Ser Glu Arg Gly Met Pro Arg
    290                 295                 300                 
Arg Arg Glu Phe Val Met Gln Val Lys Val Gly Asn Glu Val Ala Thr
305                 310                 315                 320 
Gly Thr Gly Pro Asn Lys Lys Ile Ala Lys Lys Asn Ala Ala Glu Ala
                325                 330                 335     
Met Leu Leu Gln Leu Gly Tyr Lys Ala Ser Thr Asn Leu Gln Asp Gln
            340                 345                 350         
Leu Glu Lys Thr Gly Glu Asn Lys Gly Trp Ser Gly Pro Lys Pro Gly
        355                 360                 365             
Phe Pro Glu Pro Thr Asn Asn Thr Pro Lys Gly Ile Leu His Leu Ser
    370                 375                 380                 
Pro Asp Val Tyr Gln Glu Met Glu Ala Ser Arg His Lys Val Ile Ser
385                 390                 395                 400 
Gly Thr Thr Leu Gly Tyr Leu Ser Pro Lys Asp Met Asn Gln Pro Ser
                405                 410                 415     
Ser Ser Phe Phe Ser Ile Ser Pro Thr Ser Asn Ser Ser Ala Thr Ile
            420                 425                 430         
Ala Arg Glu Leu Leu Met Asn Gly Thr Ser Ser Thr Ala Glu Ala Ile
        435                 440                 445             
Gly Leu Lys Gly Ser Ser Pro Thr Pro Pro Cys Ser Pro Val Gln Pro
    450                 455                 460                 
Ser Lys Gln Leu Glu Tyr Leu Ala Arg Ile Gln Gly Phe Gln Ala Ala
465                 470                 475                 480 
Leu Ser Ala Leu Lys Gln Phe Ser Glu Gln Gly Leu Asp Pro Ile Asp
                485                 490                 495     
Gly Ala Met Asn Ile Glu Lys Gly Ser Leu Glu Lys Gln Ala Lys His
            500                 505                 510         
Leu Arg Glu Lys Ala Asp Asn Asn Gln Ala Pro Pro Gly Ser Ile Ala
        515                 520                 525             
Gln Asp Cys Lys Lys Ser Asn Ser Ala Val
    530                 535             


<210> 1867
<211> 256
<212> PRT
<213> Homo sapiens

<400> 1867
Met Ala Ala Ala Val Gly Arg Leu Leu Arg Ala Ser Val Ala Arg His
 1               5                  10                  15      
Val Ser Ala Ile Pro Trp Gly Ile Ser Ala Thr Ala Ala Leu Trp Pro
            20                  25                  30          
Ala Ala Cys Gly Arg Thr Ser Leu Thr Asn Leu Leu Cys Ser Gly Ser
        35                  40                  45              
Ser Gln Ala Lys Leu Phe Ser Thr Ser Ser Ser Cys His Ala Pro Ala
    50                  55                  60                  
Val Thr Gln His Ala Pro Tyr Phe Lys Gly Thr Ala Val Val Asn Gly
65                  70                  75                  80  
Glu Phe Lys Asp Leu Ser Leu Asp Asp Phe Lys Gly Lys Tyr Leu Val
                85                  90                  95      
Leu Phe Phe Tyr Pro Leu Asp Phe Thr Phe Val Cys Pro Thr Glu Ile
            100                 105                 110         
Val Ala Phe Ser Asp Lys Ala Asn Glu Phe His Asp Val Asn Cys Glu
        115                 120                 125             
Val Val Ala Val Ser Val Asp Ser His Phe Ser His Leu Ala Trp Ile
    130                 135                 140                 
Asn Thr Pro Arg Lys Asn Gly Gly Leu Gly His Met Asn Ile Ala Leu
145                 150                 155                 160 
Leu Ser Asp Leu Thr Lys Gln Ile Ser Arg Asp Tyr Gly Val Leu Leu
                165                 170                 175     
Glu Gly Ser Gly Leu Ala Leu Arg Gly Leu Phe Ile Ile Asp Pro Asn
            180                 185                 190         
Gly Val Ile Lys His Leu Ser Val Asn Asp Leu Pro Val Gly Arg Ser
        195                 200                 205             
Val Glu Glu Thr Leu Arg Leu Val Lys Ala Phe Gln Tyr Val Glu Thr
    210                 215                 220                 
His Gly Glu Val Cys Pro Ala Asn Trp Thr Pro Asp Ser Pro Thr Ile
225                 230                 235                 240 
Lys Pro Ser Pro Ala Ala Ser Lys Glu Tyr Phe Gln Lys Val Asn Gln
                245                 250                 255     


<210> 1868
<211> 113
<212> PRT
<213> Homo sapiens

<400> 1868
Met Ala Ala Leu Gly Ser Pro Ala His Thr Phe Arg Gly Leu Leu Arg
 1               5                  10                  15      
Glu Leu Arg Tyr Leu Ser Ala Ala Thr Gly Arg Pro Tyr Arg Asp Thr
            20                  25                  30          
Ala Ala Tyr Arg Tyr Leu Val Lys Ala Phe Arg Ala His Arg Val Thr
        35                  40                  45              
Ser Glu Lys Leu Cys Arg Ala Gln His Glu Leu His Phe Gln Ala Ala
    50                  55                  60                  
Thr Tyr Leu Cys Leu Leu Arg Ser Ile Arg Lys His Val Ala Leu His
65                  70                  75                  80  
Gln Glu Phe His Gly Lys Gly Glu Arg Ser Val Glu Glu Ser Ala Gly
                85                  90                  95      
Leu Val Gly Leu Lys Leu Pro His Gln Pro Gly Gly Lys Gly Trp Glu
            100                 105                 110         
Pro
    


<210> 1869
<211> 537
<212> PRT
<213> Homo sapiens

<400> 1869
Leu Asn Gln His Arg Arg Ile Lys Leu Ser Pro Leu Met Met Tyr Glu
 1               5                  10                  15      
Lys Leu Ser Met Ile Arg Phe Arg Tyr Arg Ile Leu Arg Ser Gln His
            20                  25                  30          
Phe Arg Thr Lys Ser Lys Val Cys Lys Leu Arg Lys Ala Gln Arg Ser
        35                  40                  45              
Trp Val Gln Lys Val Thr Gly Asp His Gln Glu Thr Arg Arg Glu Asn
    50                  55                  60                  
Gly Glu Gly Gly Ser Cys Ser Pro Phe Pro Ser Pro Glu Pro Lys Asp
65                  70                  75                  80  
Pro Ser Cys Arg His Gln Pro Tyr Phe Pro Asp Met Asp Ser Ser Ala
                85                  90                  95      
Val Val Lys Gly Thr Asn Ser His Val Pro Asp Cys His Thr Lys Gly
            100                 105                 110         
Ser Ser Phe Leu Gly Lys Glu Leu Ser Leu Asp Glu Ala Phe Pro Asp
        115                 120                 125             
Gln Gln Asn Gly Ser Ala Thr Asn Ala Trp Asp Gln Ser Ser Cys Ser
    130                 135                 140                 
Ser Pro Lys Trp Glu Cys Thr Glu Leu Ile His Asp Ile Pro Leu Pro
145                 150                 155                 160 
Glu His Arg Ser Asn Thr Met Phe Ile Ser Glu Thr Glu Arg Glu Ile
                165                 170                 175     
Met Thr Leu Gly Gln Glu Asn Gln Thr Ser Ser Val Ser Asp Asp Arg
            180                 185                 190         
Val Lys Leu Ser Val Ser Gly Ala Asp Thr Ser Val Ser Ser Val Asp
        195                 200                 205             
Gly Pro Val Ser Gln Lys Ala Val Gln Asn Glu Asn Ser Tyr Gln Met
    210                 215                 220                 
Glu Glu Asp Gly Ser Leu Lys Gln Ser Ile Leu Ser Ser Glu Leu Leu
225                 230                 235                 240 
Asp His Pro Tyr Cys Lys Ser Pro Leu Glu Ala Pro Leu Val Cys Ser
                245                 250                 255     
Gly Leu Lys Leu Glu Asn Gln Val Gly Gly Gly Lys Asn Ser Gln Lys
            260                 265                 270         
Ala Ser Pro Val Asp Asp Glu Gln Leu Ser Val Cys Leu Ser Gly Phe
        275                 280                 285             
Leu Asp Glu Val Met Lys Lys Tyr Gly Ser Leu Val Pro Leu Ser Glu
    290                 295                 300                 
Lys Glu Val Leu Gly Arg Leu Lys Asp Val Phe Asn Glu Asp Phe Ser
305                 310                 315                 320 
Asn Arg Lys Pro Phe Ile Asn Arg Glu Ile Thr Asn Tyr Arg Ala Arg
                325                 330                 335     
His Gln Lys Cys Asn Phe Arg Ile Phe Tyr Asn Lys His Met Leu Asp
            340                 345                 350         
Met Asp Asp Leu Ala Thr Leu Asp Gly Gln Asn Trp Leu Asn Asp Gln
        355                 360                 365             
Val Ile Asn Met Tyr Gly Glu Leu Ile Met Asp Ala Val Pro Asp Lys
    370                 375                 380                 
Val His Phe Phe Asn Ser Phe Phe His Arg Gln Leu Val Thr Lys Gly
385                 390                 395                 400 
Tyr Asn Gly Val Lys Arg Trp Thr Lys Lys Val Asp Leu Phe Lys Lys
                405                 410                 415     
Ser Leu Leu Leu Ile Pro Ile His Leu Glu Val His Trp Ser Leu Ile
            420                 425                 430         
Thr Val Thr Leu Ser Asn Arg Ile Ile Ser Phe Tyr Asp Ser Gln Gly
        435                 440                 445             
Ile His Phe Lys Phe Cys Val Glu Asn Ile Arg Lys Tyr Leu Leu Thr
    450                 455                 460                 
Glu Ala Arg Glu Lys Asn Arg Pro Glu Phe Leu Gln Gly Trp Gln Thr
465                 470                 475                 480 
Ala Val Thr Lys Cys Ile Pro Gln Gln Lys Asn Asp Ser Asp Cys Gly
                485                 490                 495     
Val Phe Val Leu Gln Tyr Cys Lys Cys Leu Ala Leu Glu Gln Pro Phe
            500                 505                 510         
Gln Phe Ser Gln Glu Asp Met Pro Arg Val Arg Lys Arg Ile Tyr Lys
        515                 520                 525             
Glu Leu Cys Glu Cys Arg Leu Met Asp
    530                 535         


<210> 1870
<211> 295
<212> PRT
<213> Homo sapiens

<400> 1870
Met Leu Gln Gly Pro Gly Ser Leu Leu Leu Leu Phe Leu Ala Ser His
 1               5                  10                  15      
Cys Cys Leu Gly Ser Ala Arg Gly Leu Phe Leu Phe Gly Gln Pro Asp
            20                  25                  30          
Phe Ser Tyr Lys Arg Ser Asn Cys Lys Pro Ile Pro Val Asn Leu Gln
        35                  40                  45              
Leu Cys His Gly Ile Glu Tyr Gln Asn Met Arg Leu Pro Asn Leu Leu
    50                  55                  60                  
Gly His Glu Thr Met Lys Glu Val Leu Glu Gln Ala Gly Ala Trp Ile
65                  70                  75                  80  
Pro Leu Val Met Lys Gln Cys His Pro Asp Thr Lys Lys Phe Leu Cys
                85                  90                  95      
Ser Leu Phe Ala Pro Val Cys Leu Asp Asp Leu Asp Glu Thr Ile Gln
            100                 105                 110         
Pro Cys His Ser Leu Cys Val Gln Val Lys Asp Arg Cys Ala Pro Val
        115                 120                 125             
Met Ser Ala Phe Gly Phe Pro Trp Pro Asp Met Leu Glu Cys Asp Arg
    130                 135                 140                 
Phe Pro Gln Asp Asn Asp Leu Cys Ile Pro Leu Ala Ser Ser Asp His
145                 150                 155                 160 
Leu Leu Pro Ala Thr Glu Glu Ala Pro Lys Val Cys Glu Ala Cys Lys
                165                 170                 175     
Asn Lys Asn Asp Asp Asp Asn Asp Ile Met Glu Thr Leu Cys Lys Asn
            180                 185                 190         
Asp Phe Ala Leu Lys Ile Lys Val Lys Glu Ile Thr Tyr Ile Asn Arg
        195                 200                 205             
Asp Thr Lys Ile Ile Leu Glu Thr Lys Ser Lys Thr Ile Tyr Lys Leu
    210                 215                 220                 
Asn Gly Val Ser Glu Arg Asp Leu Lys Lys Ser Val Leu Trp Leu Lys
225                 230                 235                 240 
Asp Ser Leu Gln Cys Thr Cys Glu Glu Met Asn Asp Ile Asn Ala Pro
                245                 250                 255     
Tyr Leu Val Met Gly Gln Lys Gln Gly Gly Glu Leu Val Ile Thr Ser
            260                 265                 270         
Val Lys Arg Trp Gln Lys Gly Gln Arg Glu Phe Lys Arg Ile Ser Arg
        275                 280                 285             
Ser Ile Arg Lys Leu Gln Cys
    290                 295 


<210> 1871
<211> 1086
<212> PRT
<213> Homo sapiens

<400> 1871
Met Lys Asp Ser Cys Ile Thr Val Met Ala Met Ala Leu Leu Ser Gly
 1               5                  10                  15      
Phe Phe Phe Phe Ala Pro Ala Ser Ser Tyr Asn Leu Asp Val Arg Gly
            20                  25                  30          
Ala Arg Ser Phe Ser Pro Pro Arg Ala Gly Arg His Phe Gly Tyr Arg
        35                  40                  45              
Val Leu Gln Val Gly Asn Gly Val Ile Val Gly Ala Pro Gly Glu Gly
    50                  55                  60                  
Asn Ser Thr Gly Ser Leu Tyr Gln Cys Gln Ser Gly Thr Gly His Cys
65                  70                  75                  80  
Leu Pro Val Thr Leu Arg Gly Ser Asn Tyr Thr Ser Lys Tyr Leu Gly
                85                  90                  95      
Met Thr Leu Ala Thr Asp Pro Thr Asp Gly Ser Ile Leu Phe Ala Ala
            100                 105                 110         
Val Gln Phe Ser Thr Ser Tyr Lys Thr Glu Phe Asp Phe Ser Asp Tyr
        115                 120                 125             
Val Lys Arg Lys Asp Pro Asp Ala Leu Leu Lys His Val Lys His Met
    130                 135                 140                 
Leu Leu Leu Thr Asn Thr Phe Gly Ala Ile Asn Tyr Val Ala Thr Glu
145                 150                 155                 160 
Val Phe Arg Glu Glu Leu Gly Ala Arg Pro Asp Ala Thr Lys Val Leu
                165                 170                 175     
Ile Ile Ile Thr Asp Gly Glu Ala Thr Asp Ser Gly Asn Ile Asp Ala
            180                 185                 190         
Ala Lys Asp Ile Ile Arg Tyr Ile Ile Gly Ile Gly Lys His Phe Gln
        195                 200                 205             
Thr Lys Glu Ser Gln Glu Thr Leu His Lys Phe Ala Ser Lys Pro Ala
    210                 215                 220                 
Ser Glu Phe Val Lys Ile Leu Asp Thr Phe Glu Lys Leu Lys Asp Leu
225                 230                 235                 240 
Phe Thr Glu Leu Gln Lys Lys Ile Tyr Val Ile Glu Gly Thr Ser Lys
                245                 250                 255     
Gln Asp Leu Thr Ser Phe Asn Met Glu Leu Ser Ser Ser Gly Ile Ser
            260                 265                 270         
Ala Asp Leu Ser Arg Gly His Ala Val Val Gly Ala Val Gly Ala Lys
        275                 280                 285             
Asp Trp Ala Gly Gly Phe Leu Asp Leu Lys Ala Asp Leu Gln Asp Asp
    290                 295                 300                 
Thr Phe Ile Gly Asn Glu Pro Leu Thr Pro Glu Val Arg Ala Gly Tyr
305                 310                 315                 320 
Leu Gly Tyr Thr Val Thr Trp Leu Pro Ser Arg Gln Lys Thr Ser Leu
                325                 330                 335     
Leu Ala Ser Gly Ala Pro Arg Tyr Gln His Met Gly Arg Val Leu Leu
            340                 345                 350         
Phe Gln Glu Pro Gln Gly Gly Gly His Trp Ser Gln Val Gln Thr Ile
        355                 360                 365             
His Gly Thr Gln Ile Gly Ser Tyr Phe Gly Gly Glu Leu Cys Gly Val
    370                 375                 380                 
Asp Val Asp Gln Asp Gly Glu Thr Glu Leu Leu Leu Ile Gly Ala Pro
385                 390                 395                 400 
Leu Phe Tyr Gly Glu Gln Arg Gly Gly Arg Val Phe Ile Tyr Gln Arg
                405                 410                 415     
Arg Gln Leu Gly Phe Glu Glu Val Ser Glu Leu Gln Gly Asp Pro Gly
            420                 425                 430         
Tyr Pro Leu Gly Arg Phe Gly Glu Ala Ile Thr Ala Leu Thr Asp Ile
        435                 440                 445             
Asn Gly Asp Gly Leu Val Asp Val Ala Val Gly Ala Pro Leu Glu Glu
    450                 455                 460                 
Gln Gly Ala Val Tyr Ile Phe Asn Gly Arg His Gly Gly Leu Ser Pro
465                 470                 475                 480 
Gln Pro Ser Gln Arg Ile Glu Gly Thr Gln Val Leu Ser Gly Ile Gln
                485                 490                 495     
Trp Phe Gly Arg Ser Ile His Gly Val Lys Asp Leu Glu Gly Asp Gly
            500                 505                 510         
Leu Ala Asp Val Ala Val Gly Ala Glu Ser Gln Met Ile Val Leu Ser
        515                 520                 525             
Ser Arg Pro Val Val Asp Met Val Thr Leu Met Ser Phe Ser Pro Ala
    530                 535                 540                 
Glu Ile Pro Val His Glu Val Glu Cys Ser Tyr Ser Thr Ser Asn Lys
545                 550                 555                 560 
Met Lys Glu Gly Val Asn Ile Thr Ile Cys Phe Gln Ile Lys Ser Leu
                565                 570                 575     
Ile Pro Gln Phe Gln Gly Arg Leu Val Ala Asn Leu Thr Tyr Thr Leu
            580                 585                 590         
Gln Leu Asp Gly His Arg Thr Arg Arg Arg Gly Leu Phe Pro Gly Gly
        595                 600                 605             
Arg His Glu Leu Arg Arg Asn Ile Ala Val Thr Thr Ser Met Ser Cys
    610                 615                 620                 
Thr Asp Phe Ser Phe His Phe Pro Val Cys Val Gln Asp Leu Ile Ser
625                 630                 635                 640 
Pro Ile Asn Val Ser Leu Asn Phe Ser Leu Trp Glu Glu Glu Gly Thr
                645                 650                 655     
Pro Arg Asp Gln Arg Ala Gly Lys Asp Ile Pro Pro Ile Leu Arg Pro
            660                 665                 670         
Ser Leu His Ser Glu Thr Trp Glu Ile Pro Phe Glu Lys Asn Cys Gly
        675                 680                 685             
Glu Asp Lys Lys Cys Glu Ala Asn Leu Arg Val Ser Phe Ser Pro Ala
    690                 695                 700                 
Arg Ser Arg Ala Leu Arg Leu Thr Ala Phe Ala Ser Leu Ser Val Glu
705                 710                 715                 720 
Leu Ser Leu Ser Asn Leu Glu Glu Asp Ala Tyr Trp Val Gln Leu Asp
                725                 730                 735     
Leu His Phe Pro Pro Gly Leu Ser Phe Arg Lys Val Glu Met Leu Lys
            740                 745                 750         
Pro His Ser Gln Ile Pro Val Ser Cys Glu Glu Leu Pro Glu Glu Ser
        755                 760                 765             
Arg Leu Leu Ser Arg Ala Leu Ser Cys Asn Val Ser Ser Pro Ile Phe
    770                 775                 780                 
Lys Ala Gly His Ser Val Ala Leu Gln Met Met Phe Asn Thr Leu Val
785                 790                 795                 800 
Asn Ser Ser Trp Gly Asp Ser Val Glu Leu His Ala Asn Val Thr Cys
                805                 810                 815     
Asn Asn Glu Asp Ser Asp Leu Leu Glu Asp Asn Ser Ala Thr Thr Ile
            820                 825                 830         
Ile Pro Ile Leu Tyr Pro Ile Asn Ile Leu Ile Gln Asp Gln Glu Asp
        835                 840                 845             
Ser Thr Leu Tyr Val Ser Phe Thr Pro Lys Gly Pro Lys Ile His Gln
    850                 855                 860                 
Val Lys His Met Tyr Gln Val Arg Ile Gln Pro Ser Ile His Asp His
865                 870                 875                 880 
Asn Ile Pro Thr Leu Glu Ala Val Val Gly Val Pro Gln Pro Pro Ser
                885                 890                 895     
Glu Gly Pro Ile Thr His Gln Trp Ser Val Gln Met Glu Pro Pro Val
            900                 905                 910         
Pro Cys His Tyr Glu Asp Leu Glu Arg Leu Pro Asp Ala Ala Glu Pro
        915                 920                 925             
Cys Leu Pro Gly Ala Leu Phe Arg Cys Pro Val Val Phe Arg Gln Glu
    930                 935                 940                 
Ile Leu Val Gln Val Ile Gly Thr Leu Glu Leu Val Gly Glu Ile Glu
945                 950                 955                 960 
Ala Ser Ser Met Phe Ser Leu Cys Ser Ser Leu Ser Ile Ser Phe Asn
                965                 970                 975     
Ser Ser Lys His Phe His Leu Tyr Gly Ser Asn Ala Ser Leu Ala Gln
            980                 985                 990         
Val Val Met Lys Val Asp Val Val Tyr Glu Lys Gln Met Leu Tyr Leu
        995                 1000                1005            
Tyr Val Leu Ser Gly Ile Gly Gly Leu Leu Leu Leu Leu Leu Ile Phe
    1010                1015                1020                
Ile Val Leu Tyr Lys Val Gly Phe Phe Lys Arg Asn Leu Lys Glu Lys
1025                1030                1035                1040
Met Glu Ala Gly Arg Gly Val Pro Asn Gly Ile Pro Ala Glu Asp Ser
                1045                1050                1055    
Glu Gln Leu Ala Ser Gly Gln Glu Ala Gly Asp Pro Gly Cys Leu Lys
            1060                1065                1070        
Pro Leu His Glu Lys Asp Ser Glu Ser Gly Gly Gly Lys Asp
        1075                1080                1085    


<210> 1872
<211> 394
<212> PRT
<213> Homo sapiens

<400> 1872
Ala Arg Gly Asn Leu His Leu Phe Ser Gly His Leu Ser Thr Leu Arg
 1               5                  10                  15      
Leu Ser Phe Pro Asn Leu Phe Lys Phe Leu Ala Trp Asn Ser Pro Pro
            20                  25                  30          
Leu Thr Ser Glu Phe Val Ala Leu Leu Pro Ala Leu Val Asp Ala Gly
        35                  40                  45              
Thr Ala Leu Glu Met Leu His Ala Leu Leu Asp Leu Pro Cys Leu Thr
    50                  55                  60                  
Ala Val Leu Asp Leu Gln Leu Arg Ser Ala Pro Ala Ala Ser Glu Arg
65                  70                  75                  80  
Pro Leu Trp Asp Thr Ser Leu Arg Ala Pro Ser Cys Leu Glu Ala Phe
                85                  90                  95      
Arg Asp Pro Gln Phe Gln Gly Leu Phe Gln Tyr Leu Leu Arg Pro Lys
            100                 105                 110         
Ala Ser Gly Ala Thr Glu Arg Leu Ala Pro Leu His Gln Leu Leu Gln
        115                 120                 125             
Pro Met Ala Gly Cys Ala Arg Val Ala Gln Cys Ala Gln Ala Val Pro
    130                 135                 140                 
Thr Leu Leu Gln Ala Phe Phe Ser Ala Val Thr Gln Val Ala Asp Gly
145                 150                 155                 160 
Ser Leu Ile Asn Gln Leu Ala Leu Leu Leu Leu Gly Arg Ser Asp Ser
                165                 170                 175     
Leu Tyr Pro Ala Pro Gly Tyr Ala Ala Gly Val His Ser Val Leu Ser
            180                 185                 190         
Ser Gln Phe Leu Ala Leu Cys Thr Leu Lys Pro Ser Leu Val Val Glu
        195                 200                 205             
Leu Ala Arg Asp Leu Leu Glu Phe Leu Gly Ser Val Asn Gly Leu Cys
    210                 215                 220                 
Ser Arg Ala Ser Leu Val Thr Ser Val Val Trp Ala Ile Gly Glu Tyr
225                 230                 235                 240 
Leu Ser Val Thr Tyr Asp Arg Arg Cys Thr Val Glu Gln Ile Asn Lys
                245                 250                 255     
Phe Phe Glu Ala Leu Glu Ala Leu Leu Phe Glu Val Thr Gln Cys Arg
            260                 265                 270         
Pro Ser Ala Ala Leu Pro Arg Cys Pro Pro Gln Val Val Thr Val Leu
        275                 280                 285             
Met Thr Thr Leu Thr Lys Leu Ala Ser Arg Ser Gln Asp Leu Ile Pro
    290                 295                 300                 
Arg Ala Ser Leu Leu Leu Ser Lys Met Arg Thr Leu Ala His Ser Pro
305                 310                 315                 320 
Ala Thr Ser Ser Thr His Ser Glu Glu Gly Ala Glu Ala Ile Arg Thr
                325                 330                 335     
Arg Ala Thr Glu Leu Leu Thr Leu Leu Lys Met Pro Ser Val Ala Gln
            340                 345                 350         
Phe Val Leu Thr Pro Ser Thr Glu Val Cys Ser Pro Arg Tyr His Arg
        355                 360                 365             
Asp Ala Asn Thr Ala Leu Pro Leu Ala Leu Arg Thr Val Ser Arg Leu
    370                 375                 380                 
Val Glu Arg Glu Ala Gly Leu Met Pro Gly
385                 390                 


<210> 1873
<211> 241
<212> PRT
<213> Homo sapiens

<400> 1873
Met Ala Glu Glu Gln Pro Gln Val Glu Leu Phe Val Lys Ala Gly Ser
 1               5                  10                  15      
Asp Gly Ala Lys Ile Gly Asn Cys Pro Phe Ser Gln Arg Leu Phe Met
            20                  25                  30          
Val Leu Trp Leu Lys Gly Val Thr Phe Asn Val Thr Thr Val Asp Thr
        35                  40                  45              
Lys Arg Arg Thr Glu Thr Val Gln Lys Leu Cys Pro Gly Gly Gln Leu
    50                  55                  60                  
Pro Phe Leu Leu Tyr Gly Thr Glu Val His Thr Asp Thr Asn Lys Ile
65                  70                  75                  80  
Glu Glu Phe Leu Glu Ala Val Leu Cys Pro Pro Arg Tyr Pro Lys Leu
                85                  90                  95      
Ala Ala Leu Asn Pro Glu Ser Asn Thr Ala Gly Leu Asp Ile Phe Ala
            100                 105                 110         
Lys Phe Ser Ala Tyr Ile Lys Asn Ser Asn Pro Ala Leu Asn Asp Asn
        115                 120                 125             
Leu Glu Lys Gly Leu Leu Lys Ala Leu Lys Val Leu Asp Asn Tyr Leu
    130                 135                 140                 
Thr Ser Pro Leu Pro Glu Glu Val Asp Glu Thr Ser Ala Glu Asp Glu
145                 150                 155                 160 
Gly Val Ser Gln Arg Lys Phe Leu Asp Gly Asn Glu Leu Thr Leu Ala
                165                 170                 175     
Asp Cys Asn Leu Leu Pro Lys Leu His Ile Val Gln Val Val Cys Lys
            180                 185                 190         
Lys Tyr Arg Gly Phe Thr Ile Pro Glu Ala Phe Arg Gly Val His Arg
        195                 200                 205             
Tyr Leu Ser Asn Ala Tyr Ala Arg Glu Glu Phe Ala Ser Thr Cys Pro
    210                 215                 220                 
Asp Asp Glu Glu Ile Glu Leu Ala Tyr Glu Gln Val Ala Lys Ala Leu
225                 230                 235                 240 
Lys
    


<210> 1874
<211> 62
<212> PRT
<213> Homo sapiens

<400> 1874
Met Asp Pro Arg Glu Cys Val Cys Met Ser Gly Gly Ile Cys Met Cys
 1               5                  10                  15      
Gly Asp Asn Cys Lys Cys Thr Thr Cys Asn Cys Lys Thr Cys Arg Lys
            20                  25                  30          
Ser Cys Cys Pro Cys Cys Pro Pro Gly Cys Ala Lys Cys Ala Arg Gly
        35                  40                  45              
Cys Ile Cys Lys Gly Gly Ser Asp Lys Cys Ser Cys Cys Pro
    50                  55                  60          


<210> 1875
<211> 379
<212> PRT
<213> Homo sapiens

<400> 1875
Met Glu Glu Leu Gln Asp Asp Tyr Glu Asp Met Met Glu Glu Asn Leu
 1               5                  10                  15      
Glu Gln Glu Glu Tyr Glu Asp Pro Asp Ile Pro Glu Ser Gln Met Glu
            20                  25                  30          
Glu Pro Ala Ala His Asp Thr Glu Ala Thr Ala Thr Asp Tyr His Thr
        35                  40                  45              
Thr Ser His Pro Gly Thr His Lys Val Tyr Val Glu Leu Gln Glu Leu
    50                  55                  60                  
Val Met Asp Glu Lys Asn Gln Glu Leu Arg Trp Met Glu Ala Ala Arg
65                  70                  75                  80  
Trp Val Gln Leu Glu Glu Asn Leu Gly Glu Asn Gly Ala Trp Gly Arg
                85                  90                  95      
Pro His Leu Ser His Leu Thr Phe Trp Ser Leu Leu Glu Leu Arg Arg
            100                 105                 110         
Val Phe Thr Lys Gly Thr Val Leu Leu Asp Leu Gln Glu Thr Ser Leu
        115                 120                 125             
Ala Gly Val Ala Asn Gln Leu Leu Asp Arg Phe Ile Phe Glu Asp Gln
    130                 135                 140                 
Ile Arg Pro Gln Asp Arg Glu Glu Leu Leu Arg Ala Leu Leu Leu Lys
145                 150                 155                 160 
His Ser His Ala Gly Glu Leu Glu Ala Leu Gly Gly Val Lys Pro Ala
                165                 170                 175     
Val Leu Thr Arg Ser Gly Asp Pro Ser Gln Pro Leu Leu Pro Gln His
            180                 185                 190         
Ser Ser Leu Glu Thr Gln Leu Phe Cys Glu Gln Gly Asp Gly Gly Thr
        195                 200                 205             
Glu Gly His Ser Pro Ser Gly Ile Leu Glu Lys Ile Pro Pro Asp Ser
    210                 215                 220                 
Glu Ala Thr Leu Val Leu Val Gly Arg Ala Asp Phe Leu Glu Gln Pro
225                 230                 235                 240 
Val Leu Gly Phe Val Arg Leu Gln Glu Ala Ala Glu Leu Glu Ala Val
                245                 250                 255     
Glu Leu Pro Val Pro Ile Arg Phe Leu Phe Val Leu Leu Gly Pro Glu
            260                 265                 270         
Ala Pro His Ile Asp Tyr Thr Gln Leu Gly Arg Ala Ala Ala Thr Leu
        275                 280                 285             
Met Ser Glu Arg Val Phe Arg Ile Asp Ala Tyr Met Ala Gln Ser Arg
    290                 295                 300                 
Gly Glu Leu Leu His Ser Leu Glu Gly Phe Leu Asp Cys Ser Leu Val
305                 310                 315                 320 
Leu Pro Pro Thr Asp Ala Pro Ser Glu Gln Ala Leu Leu Ser Leu Val
                325                 330                 335     
Pro Val Gln Arg Glu Leu Leu Arg Arg Arg Tyr Gln Ser Ser Pro Ala
            340                 345                 350         
Lys Pro Asp Ser Ser Phe Tyr Lys Gly Leu Asp Leu Asn Gly Gly Pro
        355                 360                 365             
Asp Asp Pro Leu Gln Gln Thr Gly Gln Leu Phe
    370                 375                 


<210> 1876
<211> 875
<212> PRT
<213> Homo sapiens

<400> 1876
Met His Asp Ala Phe Glu Pro Val Pro Ile Leu Glu Lys Leu Pro Leu
 1               5                  10                  15      
Gln Ile Asp Cys Leu Ala Ala Trp Glu Glu Trp Leu Leu Val Gly Thr
            20                  25                  30          
Lys Gln Gly His Leu Leu Leu Tyr Arg Ile Arg Lys Asp Val Gly Cys
        35                  40                  45              
Asn Arg Phe Glu Val Thr Leu Glu Lys Ser Asn Lys Asn Phe Ser Lys
    50                  55                  60                  
Lys Ile Gln Gln Ile His Val Val Ser Gln Phe Lys Ile Leu Val Ser
65                  70                  75                  80  
Leu Leu Glu Asn Asn Ile Tyr Val His Asp Leu Leu Thr Phe Gln Gln
                85                  90                  95      
Ile Thr Thr Val Ser Lys Ala Lys Gly Ala Ser Leu Phe Thr Cys Asp
            100                 105                 110         
Leu Gln His Thr Glu Thr Gly Glu Glu Val Leu Arg Met Cys Val Ala
        115                 120                 125             
Val Lys Lys Lys Leu Gln Leu Tyr Phe Trp Lys Asp Arg Glu Phe His
    130                 135                 140                 
Glu Leu Gln Gly Asp Phe Ser Val Pro Asp Val Pro Lys Ser Met Ala
145                 150                 155                 160 
Trp Cys Glu Asn Ser Ile Cys Val Gly Phe Lys Arg Asp Tyr Tyr Leu
                165                 170                 175     
Ile Arg Val Asp Gly Lys Gly Ser Ile Lys Glu Leu Phe Pro Thr Gly
            180                 185                 190         
Lys Gln Leu Glu Pro Leu Val Ala Pro Leu Ala Asp Gly Lys Val Ala
        195                 200                 205             
Val Gly Gln Asp Asp Leu Thr Val Val Leu Asn Glu Glu Gly Ile Cys
    210                 215                 220                 
Thr Gln Lys Cys Ala Leu Asn Trp Thr Asp Ile Pro Val Ala Met Glu
225                 230                 235                 240 
His Gln Pro Pro Tyr Ile Ile Ala Val Leu Pro Arg Tyr Val Glu Ile
                245                 250                 255     
Arg Thr Phe Glu Pro Arg Leu Leu Val Gln Ser Ile Glu Leu Gln Arg
            260                 265                 270         
Pro Arg Phe Ile Thr Ser Gly Gly Ser Asn Ile Ile Tyr Val Ala Ser
        275                 280                 285             
Asn His Phe Val Trp Arg Leu Ile Pro Val Pro Met Ala Thr Gln Ile
    290                 295                 300                 
Gln Gln Leu Leu Gln Asp Lys Gln Phe Glu Leu Ala Leu Gln Leu Ala
305                 310                 315                 320 
Glu Met Lys Asp Asp Ser Asp Ser Glu Lys Gln Gln Gln Ile His His
                325                 330                 335     
Ile Lys Asn Leu Tyr Ala Phe Asn Leu Phe Cys Gln Lys Arg Phe Asp
            340                 345                 350         
Glu Ser Met Gln Val Phe Ala Lys Leu Gly Thr Asp Pro Thr His Val
        355                 360                 365             
Met Gly Leu Tyr Pro Asp Leu Leu Pro Thr Asp Tyr Arg Lys Gln Leu
    370                 375                 380                 
Gln Tyr Pro Asn Pro Leu Pro Val Leu Ser Gly Ala Glu Leu Glu Lys
385                 390                 395                 400 
Ala His Leu Ala Leu Ile Asp Tyr Leu Thr Gln Lys Arg Ser Gln Leu
                405                 410                 415     
Val Lys Lys Leu Asn Asp Ser Asp His Gln Ser Ser Thr Ser Pro Leu
            420                 425                 430         
Met Glu Gly Thr Pro Thr Ile Lys Ser Lys Lys Lys Leu Leu Gln Ile
        435                 440                 445             
Ile Asp Thr Thr Leu Leu Lys Cys Tyr Leu His Thr Asn Val Ala Leu
    450                 455                 460                 
Val Ala Pro Leu Leu Arg Leu Glu Asn Asn His Cys His Ile Glu Glu
465                 470                 475                 480 
Ser Glu His Val Leu Lys Lys Ala His Lys Tyr Ser Glu Leu Ile Ile
                485                 490                 495     
Leu Tyr Glu Lys Lys Gly Leu His Glu Lys Ala Leu Gln Val Leu Val
            500                 505                 510         
Asp Gln Ser Lys Lys Ala Asn Ser Pro Leu Lys Gly His Glu Arg Thr
        515                 520                 525             
Val Gln Tyr Leu Gln His Leu Gly Thr Glu Asn Leu His Leu Ile Phe
    530                 535                 540                 
Ser Tyr Ser Val Trp Val Leu Arg Asp Phe Pro Glu Asp Gly Leu Lys
545                 550                 555                 560 
Ile Phe Thr Glu Asp Leu Pro Glu Val Glu Ser Leu Pro Arg Asp Arg
                565                 570                 575     
Val Leu Gly Phe Leu Ile Glu Asn Phe Lys Gly Leu Ala Ile Pro Tyr
            580                 585                 590         
Leu Glu His Ile Ile His Val Trp Glu Glu Thr Gly Ser Arg Phe His
        595                 600                 605             
Asn Cys Leu Ile Gln Leu Tyr Cys Glu Lys Val Gln Gly Leu Met Lys
    610                 615                 620                 
Glu Tyr Leu Leu Ser Phe Pro Ala Gly Lys Thr Pro Val Pro Ala Gly
625                 630                 635                 640 
Glu Glu Glu Gly Glu Leu Gly Glu Tyr Arg Gln Lys Leu Leu Met Phe
                645                 650                 655     
Leu Glu Ile Ser Ser Tyr Tyr Asp Pro Gly Arg Leu Ile Cys Asp Phe
            660                 665                 670         
Pro Phe Asp Gly Leu Leu Glu Glu Arg Ala Leu Leu Leu Gly Arg Met
        675                 680                 685             
Gly Lys His Glu Gln Ala Leu Phe Ile Tyr Val His Ile Leu Lys Asp
    690                 695                 700                 
Thr Arg Met Ala Glu Glu Tyr Cys His Lys His Tyr Asp Arg Asn Lys
705                 710                 715                 720 
Asp Gly Asn Lys Asp Val Tyr Leu Ser Leu Leu Arg Met Tyr Leu Ser
                725                 730                 735     
Pro Pro Ser Ile His Cys Leu Gly Pro Ile Lys Leu Glu Leu Leu Glu
            740                 745                 750         
Pro Lys Ala Asn Leu Gln Ala Ala Leu Gln Val Leu Glu Leu His His
        755                 760                 765             
Ser Lys Leu Asp Thr Thr Lys Ala Leu Asn Leu Leu Pro Ala Asn Thr
    770                 775                 780                 
Gln Ile Asn Asp Ile Arg Ile Phe Leu Glu Lys Val Leu Glu Glu Asn
785                 790                 795                 800 
Ala Gln Lys Lys Arg Phe Asn Gln Val Leu Lys Asn Leu Leu His Ala
                805                 810                 815     
Glu Phe Leu Arg Val Gln Glu Glu Arg Ile Leu His Gln Gln Val Lys
            820                 825                 830         
Cys Ile Ile Thr Glu Glu Lys Val Cys Met Val Cys Lys Lys Lys Ile
        835                 840                 845             
Gly Asn Ser Ala Phe Ala Arg Tyr Pro Asn Gly Val Val Val His Tyr
    850                 855                 860                 
Phe Cys Ser Lys Glu Val Asn Pro Ala Asp Thr
865                 870                 875 


<210> 1877
<211> 751
<212> PRT
<213> Homo sapiens

<400> 1877
Met Arg Leu Leu Gly Ala Ala Ala Val Ala Ala Leu Gly Arg Gly Arg
 1               5                  10                  15      
Ala Pro Ala Ser Leu Gly Trp Gln Arg Lys Gln Val Asn Trp Lys Ala
            20                  25                  30          
Cys Arg Trp Ser Ser Ser Gly Val Ile Pro Asn Glu Lys Ile Arg Asn
        35                  40                  45              
Ile Gly Ile Ser Ala His Ile Asp Ser Gly Lys Thr Thr Leu Thr Glu
    50                  55                  60                  
Arg Val Leu Tyr Tyr Thr Gly Arg Ile Ala Lys Met His Glu Val Lys
65                  70                  75                  80  
Gly Lys Asp Gly Val Gly Ala Val Met Asp Ser Met Glu Leu Glu Arg
                85                  90                  95      
Gln Arg Gly Ile Thr Ile Gln Ser Ala Ala Thr Tyr Thr Met Trp Lys
            100                 105                 110         
Asp Val Asn Ile Asn Ile Ile Asp Thr Pro Gly His Val Asp Phe Thr
        115                 120                 125             
Ile Glu Val Glu Arg Ala Leu Arg Val Leu Asp Gly Ala Val Leu Val
    130                 135                 140                 
Leu Cys Ala Val Gly Gly Val Gln Cys Gln Thr Met Thr Val Asn Arg
145                 150                 155                 160 
Gln Met Lys Arg Tyr Asn Val Pro Phe Leu Thr Phe Ile Asn Lys Leu
                165                 170                 175     
Asp Arg Met Gly Ser Asn Pro Ala Arg Ala Leu Gln Gln Met Arg Ser
            180                 185                 190         
Lys Leu Asn His Asn Ala Ala Phe Met Gln Ile Pro Met Gly Leu Glu
        195                 200                 205             
Gly Asn Phe Lys Gly Ile Val Asp Leu Ile Glu Glu Arg Ala Ile Tyr
    210                 215                 220                 
Phe Asp Gly Asp Phe Gly Gln Ile Val Arg Tyr Gly Glu Ile Pro Ala
225                 230                 235                 240 
Glu Leu Arg Ala Ala Ala Thr Asp His Arg Gln Glu Leu Ile Glu Cys
                245                 250                 255     
Val Ala Asn Ser Asp Glu Gln Leu Gly Glu Met Phe Leu Glu Glu Lys
            260                 265                 270         
Ile Pro Ser Ile Ser Asp Leu Lys Leu Ala Ile Arg Arg Ala Thr Leu
        275                 280                 285             
Lys Arg Ser Phe Thr Pro Val Phe Leu Gly Ser Ala Leu Lys Asn Lys
    290                 295                 300                 
Gly Val Gln Pro Leu Leu Asp Ala Val Leu Glu Tyr Leu Pro Asn Pro
305                 310                 315                 320 
Ser Glu Val Gln Asn Tyr Ala Ile Leu Asn Lys Glu Asp Asp Ser Lys
                325                 330                 335     
Glu Lys Thr Lys Ile Leu Met Asn Ser Ser Arg Asp Asn Ser His Pro
            340                 345                 350         
Phe Val Gly Leu Ala Phe Lys Leu Glu Val Gly Arg Phe Gly Gln Leu
        355                 360                 365             
Thr Tyr Val Arg Cys Tyr Gln Gly Glu Leu Lys Lys Gly Asp Thr Ile
    370                 375                 380                 
Tyr Asn Thr Arg Thr Arg Lys Lys Val Arg Leu Gln Arg Leu Ala Arg
385                 390                 395                 400 
Met His Ala Asp Met Met Glu Asp Val Glu Glu Val Tyr Ala Gly Asp
                405                 410                 415     
Ile Cys Ala Leu Phe Gly Ile Asp Cys Ala Ser Gly Asp Thr Phe Thr
            420                 425                 430         
Asp Lys Ala Asn Ser Gly Leu Ser Met Glu Ser Ile His Val Pro Asp
        435                 440                 445             
Pro Val Ile Ser Ile Ala Met Lys Pro Ser Asn Lys Asn Asp Leu Glu
    450                 455                 460                 
Lys Phe Ser Lys Gly Ile Gly Arg Phe Thr Arg Glu Asp Pro Thr Phe
465                 470                 475                 480 
Lys Val Tyr Phe Asp Thr Glu Asn Lys Glu Thr Val Ile Ser Gly Met
                485                 490                 495     
Gly Glu Leu His Leu Glu Ile Tyr Ala Gln Arg Leu Glu Arg Glu Tyr
            500                 505                 510         
Gly Cys Pro Cys Ile Thr Gly Lys Pro Lys Val Ala Phe Arg Glu Thr
        515                 520                 525             
Ile Thr Ala Pro Val Pro Phe Asp Phe Thr His Lys Lys Gln Ser Gly
    530                 535                 540                 
Gly Ala Gly Gln Tyr Gly Lys Val Ile Gly Val Leu Glu Pro Leu Asp
545                 550                 555                 560 
Pro Glu Asp Tyr Thr Lys Leu Glu Phe Ser Asp Glu Thr Phe Gly Ser
                565                 570                 575     
Asn Met Pro Lys Gln Phe Val Pro Ala Val Glu Lys Gly Phe Leu Asp
            580                 585                 590         
Ala Cys Glu Lys Gly Pro Leu Ser Gly His Lys Leu Ser Gly Leu Arg
        595                 600                 605             
Phe Val Leu Gln Asp Gly Ala His His Met Val Asp Ser Asn Glu Ile
    610                 615                 620                 
Ser Phe Ile Arg Ala Gly Glu Gly Ala Leu Lys Gln Ala Leu Ala Asn
625                 630                 635                 640 
Ala Thr Leu Cys Ile Leu Glu Pro Ile Met Ala Val Glu Val Val Ala
                645                 650                 655     
Pro Asn Glu Phe Gln Gly Gln Val Ile Ala Gly Ile Asn Arg Arg His
            660                 665                 670         
Gly Val Ile Thr Gly Gln Asp Gly Val Glu Asp Tyr Phe Thr Leu Tyr
        675                 680                 685             
Ala Asp Val Pro Leu Asn Asp Met Phe Gly Tyr Ser Thr Glu Leu Arg
    690                 695                 700                 
Ser Cys Thr Glu Gly Lys Gly Glu Tyr Thr Met Glu Tyr Ser Arg Tyr
705                 710                 715                 720 
Gln Pro Cys Leu Pro Ser Thr Gln Glu Asp Val Ile Asn Lys Tyr Leu
                725                 730                 735     
Glu Ala Thr Gly Gln Leu Pro Val Lys Lys Gly Lys Ala Lys Asn
            740                 745                 750     


<210> 1878
<211> 457
<212> PRT
<213> Homo sapiens

<400> 1878
Met Thr Thr Glu Asp Tyr Lys Lys Leu Ala Pro Tyr Asn Ile Arg Arg
 1               5                  10                  15      
Ser Ser Thr Ser Gly Asp Thr Glu Glu Glu Glu Glu Glu Glu Val Val
            20                  25                  30          
Pro Phe Ser Ser Asp Glu Gln Lys Arg Arg Ser Glu Ala Ala Ser Gly
        35                  40                  45              
Val Leu Arg Arg Thr Ala Pro Arg Glu His Ser Tyr Val Leu Ser Ala
    50                  55                  60                  
Ala Lys Lys Ser Thr Gly Ser Pro Thr Gln Glu Thr Gln Ala Pro Phe
65                  70                  75                  80  
Ile Ala Lys Arg Val Glu Val Val Glu Glu Asp Gly Pro Ser Glu Lys
                85                  90                  95      
Ser Gln Asp Pro Pro Ala Leu Ala Arg Ser Thr Pro Gly Ser Asn Ser
            100                 105                 110         
Ser Arg Gly Glu Glu Ile Val Arg Leu Gln Ile Leu Thr Pro Arg Ala
        115                 120                 125             
Gly Leu Arg Leu Val Ala Pro Asp Val Glu Gly Met Ser Ser Ser Ala
    130                 135                 140                 
Thr Ser Val Ser Ala Val Pro Ala Asp Arg Lys Ser Asn Ser Thr Ala
145                 150                 155                 160 
Ala Gln Glu Asp Ala Lys Ala Asp Pro Lys Gly Ala Leu Ala Asp Tyr
                165                 170                 175     
Glu Gly Lys Asp Val Ala Thr Arg Val Gly Glu Ala Trp Gln Glu Arg
            180                 185                 190         
Pro Gly Ala Pro Arg Gly Gly Gln Gly Asp Pro Ala Val Pro Ala Gln
        195                 200                 205             
Gln Pro Ala Asp Pro Ser Thr Pro Glu Arg Gln Ser Ser Pro Ser Gly
    210                 215                 220                 
Ser Glu Gln Leu Val Arg Arg Glu Ser Cys Gly Ser Ser Val Leu Thr
225                 230                 235                 240 
Asp Phe Glu Gly Lys Asp Val Ala Thr Lys Val Gly Glu Ala Trp Gln
                245                 250                 255     
Asp Arg Pro Gly Ala Pro Arg Gly Gly Gln Gly Asp Pro Ala Val Pro
            260                 265                 270         
Thr Gln Gln Pro Ala Asp Pro Ser Thr Pro Glu Gln Gln Asn Ser Pro
        275                 280                 285             
Ser Gly Ser Glu Gln Phe Val Arg Arg Glu Ser Cys Thr Ser Arg Val
    290                 295                 300                 
Arg Ser Pro Ser Ser Cys Met Val Thr Val Thr Val Thr Ala Thr Ser
305                 310                 315                 320 
Glu Gln Pro His Ile Tyr Ile Pro Ala Pro Ala Ser Glu Leu Asp Ser
                325                 330                 335     
Ser Ser Thr Thr Lys Gly Ile Leu Phe Val Lys Glu Tyr Val Asn Ala
            340                 345                 350         
Ser Glu Val Ser Ser Gly Lys Pro Val Ser Ala Arg Tyr Ser Asn Val
        355                 360                 365             
Ser Ser Ile Glu Asp Ser Phe Ala Met Glu Lys Lys Pro Pro Cys Gly
    370                 375                 380                 
Ser Thr Pro Tyr Ser Glu Arg Thr Thr Gly Gly Ile Cys Thr Tyr Cys
385                 390                 395                 400 
Asn Arg Glu Ile Arg Asp Cys Pro Lys Ile Thr Leu Glu His Leu Gly
                405                 410                 415     
Ile Cys Cys His Glu Tyr Cys Phe Lys Cys Gly Ile Cys Ser Lys Pro
            420                 425                 430         
Met Gly Asp Leu Leu Asp Gln Ile Phe Ile His Arg Asp Thr Ile His
        435                 440                 445             
Cys Gly Lys Cys Tyr Glu Lys Leu Phe
    450                 455         


<210> 1879
<211> 464
<212> PRT
<213> Homo sapiens

<400> 1879
Met Ser Ser Arg Ser Thr Lys Asp Leu Ile Lys Ser Lys Trp Gly Ser
 1               5                  10                  15      
Lys Pro Ser Asn Ser Lys Ser Glu Thr Thr Leu Glu Lys Leu Lys Gly
            20                  25                  30          
Glu Ile Ala His Leu Lys Thr Ser Val Asp Glu Ile Thr Ser Gly Lys
        35                  40                  45              
Gly Lys Leu Thr Asp Lys Glu Arg His Arg Leu Leu Glu Lys Ile Arg
    50                  55                  60                  
Val Leu Glu Ala Glu Lys Glu Lys Asn Ala Tyr Gln Leu Thr Glu Lys
65                  70                  75                  80  
Asp Lys Glu Ile Gln Arg Leu Arg Asp Gln Leu Lys Ala Arg Tyr Ser
                85                  90                  95      
Thr Thr Ala Leu Leu Glu Gln Leu Glu Glu Thr Thr Arg Glu Gly Glu
            100                 105                 110         
Arg Arg Glu Gln Val Leu Lys Ala Leu Ser Glu Glu Lys Asp Val Leu
        115                 120                 125             
Lys Gln Gln Leu Ser Ala Ala Thr Ser Arg Ile Ala Glu Leu Glu Ser
    130                 135                 140                 
Lys Thr Asn Thr Leu Arg Leu Ser Gln Thr Val Ala Pro Asn Cys Phe
145                 150                 155                 160 
Asn Ser Ser Ile Asn Asn Ile His Glu Met Glu Ile Gln Leu Lys Asp
                165                 170                 175     
Ala Leu Glu Lys Asn Gln Gln Trp Leu Val Tyr Asp Gln Gln Arg Glu
            180                 185                 190         
Val Tyr Val Lys Gly Leu Leu Ala Lys Ile Phe Glu Leu Glu Lys Lys
        195                 200                 205             
Thr Glu Thr Ala Ala His Ser Leu Pro Gln Gln Thr Lys Lys Pro Glu
    210                 215                 220                 
Ser Glu Gly Tyr Leu Gln Glu Glu Lys Gln Lys Cys Tyr Asn Asp Leu
225                 230                 235                 240 
Leu Ala Ser Ala Lys Lys Asp Leu Glu Val Glu Arg Gln Thr Ile Thr
                245                 250                 255     
Gln Leu Ser Phe Glu Leu Ser Glu Phe Arg Arg Lys Tyr Glu Glu Thr
            260                 265                 270         
Gln Lys Glu Val His Asn Leu Asn Gln Leu Leu Tyr Ser Gln Arg Arg
        275                 280                 285             
Ala Asp Val Gln His Leu Glu Asp Asp Arg His Lys Thr Glu Lys Ile
    290                 295                 300                 
Gln Lys Leu Arg Glu Glu Asn Asp Ile Ala Arg Gly Lys Leu Glu Glu
305                 310                 315                 320 
Glu Lys Lys Arg Ser Glu Glu Leu Leu Ser Gln Val Gln Phe Leu Tyr
                325                 330                 335     
Thr Ser Leu Leu Lys Gln Gln Glu Glu Gln Thr Arg Val Ala Leu Leu
            340                 345                 350         
Glu Gln Gln Met Gln Ala Cys Thr Leu Asp Phe Glu Asn Glu Lys Leu
        355                 360                 365             
Asp Arg Gln His Val Gln His Gln Leu Leu Val Ile Leu Lys Glu Leu
    370                 375                 380                 
Arg Lys Ala Arg Asn Gln Ile Thr Gln Leu Glu Ser Leu Lys Gln Leu
385                 390                 395                 400 
His Glu Phe Ala Ile Thr Glu Pro Leu Val Thr Phe Gln Gly Glu Thr
                405                 410                 415     
Glu Asn Arg Glu Lys Val Ala Ala Ser Pro Lys Ser Pro Thr Ala Ala
            420                 425                 430         
Leu Asn Glu Ser Leu Val Glu Cys Pro Lys Cys Asn Ile Gln Tyr Pro
        435                 440                 445             
Ala Thr Glu His Arg Asp Leu Leu Val His Val Glu Tyr Cys Ser Lys
    450                 455                 460                 


<210> 1880
<211> 2392
<212> PRT
<213> Homo sapiens

<400> 1880
Met Lys Lys Leu Leu Pro Asn Met Leu Ser Pro Asp Pro Arg Glu Leu
 1               5                  10                  15      
Gln Lys Ser Ile Glu Val Gln Leu Leu Arg Ser Ser Val Cys Leu Ala
            20                  25                  30          
Thr Ala Leu Asn Pro Ile Glu Gln Asp Gln Lys Trp Gln Ser Ile Thr
        35                  40                  45              
Glu Asn Val Val Lys Tyr Leu Lys Gln Thr Ser Arg Ile Ala Ile Gly
    50                  55                  60                  
Pro Leu Arg Leu Ser Thr Leu Thr Val Ser Gln Ser Leu Pro Val Leu
65                  70                  75                  80  
Ser Thr Leu Gln Leu Tyr Cys Ser Ser Ala Leu Glu Asn Thr Val Ser
                85                  90                  95      
Asn Arg Leu Ser Thr Glu Asp Cys Leu Ile Pro Leu Phe Ser Glu Ala
            100                 105                 110         
Leu Arg Ser Cys Lys Gln His Asp Val Arg Pro Trp Met Gln Ala Leu
        115                 120                 125             
Arg Tyr Thr Met Tyr Gln Asn Gln Leu Leu Glu Lys Ile Lys Glu Gln
    130                 135                 140                 
Thr Val Pro Ile Arg Ser His Leu Met Glu Leu Gly Leu Thr Ala Ala
145                 150                 155                 160 
Lys Phe Ala Arg Lys Arg Gly Asn Val Ser Leu Ala Thr Arg Leu Leu
                165                 170                 175     
Ala Gln Cys Ser Glu Val Gln Leu Gly Lys Thr Thr Thr Ala Gln Asp
            180                 185                 190         
Leu Val Gln His Phe Lys Lys Leu Ser Thr Gln Gly Gln Val Asp Glu
        195                 200                 205             
Lys Trp Gly Pro Glu Leu Asp Ile Glu Lys Thr Lys Leu Leu Tyr Thr
    210                 215                 220                 
Ala Gly Gln Ser Thr His Ala Met Glu Met Leu Ser Ser Cys Ala Ile
225                 230                 235                 240 
Ser Phe Cys Lys Ser Val Lys Ala Glu Tyr Ala Val Ala Lys Ser Ile
                245                 250                 255     
Leu Thr Leu Ala Lys Trp Ile Gln Ala Glu Trp Lys Glu Ile Ser Gly
            260                 265                 270         
Gln Leu Lys Gln Val Tyr Arg Ala Gln His Gln Gln Asn Phe Thr Gly
        275                 280                 285             
Leu Ser Thr Leu Ser Lys Asn Ile Leu Thr Leu Ile Glu Leu Pro Ser
    290                 295                 300                 
Val Asn Thr Met Glu Glu Glu Tyr Pro Arg Ile Glu Ser Glu Ser Thr
305                 310                 315                 320 
Val His Ile Gly Val Gly Glu Pro Asp Phe Ile Leu Gly Gln Leu Tyr
                325                 330                 335     
His Leu Ser Ser Val Gln Ala Pro Glu Val Ala Lys Ser Trp Ala Ala
            340                 345                 350         
Leu Ala Ser Trp Ala Tyr Arg Trp Gly Arg Lys Val Val Asp Asn Ala
        355                 360                 365             
Ser Gln Gly Glu Gly Val Arg Leu Leu Pro Arg Glu Lys Ser Glu Val
    370                 375                 380                 
Gln Asn Leu Leu Pro Asp Thr Ile Thr Glu Glu Glu Lys Glu Arg Ile
385                 390                 395                 400 
Tyr Gly Ile Leu Gly Gln Ala Val Cys Arg Pro Ala Gly Ile Gln Asp
                405                 410                 415     
Glu Asp Ile Thr Leu Gln Ile Thr Glu Ser Glu Asp Asn Glu Glu Asp
            420                 425                 430         
Asp Met Val Asp Val Ile Trp Arg Gln Leu Ile Ser Ser Cys Pro Trp
        435                 440                 445             
Leu Ser Glu Leu Asp Glu Ser Ala Thr Glu Gly Val Ile Lys Val Trp
    450                 455                 460                 
Arg Lys Val Val Asp Arg Ile Phe Ser Leu Tyr Lys Leu Ser Cys Ser
465                 470                 475                 480 
Ala Tyr Phe Thr Phe Leu Lys Leu Asn Ala Gly Gln Ile Pro Leu Asp
                485                 490                 495     
Glu Asp Asp Pro Arg Leu His Leu Ser His Arg Val Glu Gln Ser Thr
            500                 505                 510         
Asp Asp Met Ile Val Met Ala Thr Leu Arg Leu Leu Arg Leu Leu Val
        515                 520                 525             
Lys His Ala Gly Glu Leu Arg Gln Tyr Leu Glu His Gly Leu Glu Thr
    530                 535                 540                 
Thr Pro Thr Ala Pro Trp Arg Gly Ile Ile Pro Gln Leu Phe Ser Arg
545                 550                 555                 560 
Leu Asn His Pro Glu Val Tyr Val Arg Gln Ser Ile Cys Asn Leu Leu
                565                 570                 575     
Cys Arg Val Ala Gln Asp Ser Pro His Leu Ile Leu Tyr Pro Ala Ile
            580                 585                 590         
Val Gly Thr Ile Ser Leu Ser Ser Glu Ser Gln Ala Ser Gly Asn Lys
        595                 600                 605             
Phe Ser Thr Ala Ile Pro Thr Leu Leu Gly Asn Ile Gln Gly Glu Glu
    610                 615                 620                 
Leu Leu Val Ser Glu Cys Glu Gly Gly Ser Pro Pro Ala Ser Gln Asp
625                 630                 635                 640 
Ser Asn Lys Asp Glu Pro Lys Ser Gly Leu Asn Glu Asp Gln Ala Met
                645                 650                 655     
Met Gln Asp Cys Tyr Ser Lys Ile Val Asp Lys Leu Ser Ser Ala Asn
            660                 665                 670         
Pro Thr Met Val Leu Gln Val Gln Met Leu Val Ala Glu Leu Arg Arg
        675                 680                 685             
Val Thr Val Leu Trp Asp Glu Leu Trp Leu Gly Val Leu Leu Gln Gln
    690                 695                 700                 
His Met Tyr Val Leu Arg Arg Ile Gln Gln Leu Glu Asp Glu Val Lys
705                 710                 715                 720 
Arg Val Gln Asn Asn Asn Thr Leu Arg Lys Glu Glu Lys Ile Ala Ile
                725                 730                 735     
Met Arg Glu Lys His Thr Ala Leu Met Lys Pro Ile Val Phe Ala Leu
            740                 745                 750         
Glu His Val Arg Ser Ile Thr Ala Ala Pro Ala Glu Thr Pro His Glu
        755                 760                 765             
Lys Trp Phe Gln Asp Asn Tyr Gly Asp Ala Ile Glu Asn Ala Leu Glu
    770                 775                 780                 
Lys Leu Lys Thr Pro Leu Asn Pro Ala Lys Pro Gly Ser Ser Trp Ile
785                 790                 795                 800 
Pro Phe Lys Glu Ile Met Leu Asn Leu Gln Gln Arg Ala Gln Lys Arg
                805                 810                 815     
Ala Ser Tyr Ile Leu Arg Leu Glu Glu Ile Ser Pro Trp Leu Ala Ala
            820                 825                 830         
Met Thr Asn Thr Glu Ile Ala Leu Pro Gly Glu Val Ser Ala Arg Asp
        835                 840                 845             
Thr Val Thr Ile His Ser Val Gly Gly Thr Ile Thr Ile Leu Pro Thr
    850                 855                 860                 
Lys Thr Lys Pro Lys Lys Leu Leu Phe Leu Gly Ser Asp Gly Lys Ser
865                 870                 875                 880 
Tyr Pro Tyr Leu Phe Lys Gly Leu Glu Asp Leu His Leu Asp Glu Arg
                885                 890                 895     
Ile Met Gln Phe Leu Ser Ile Val Asn Thr Met Phe Ala Thr Ile Asn
            900                 905                 910         
Arg Gln Glu Thr Pro Arg Phe His Ala Arg His Tyr Ser Val Thr Pro
        915                 920                 925             
Leu Gly Thr Arg Ser Gly Leu Ile Gln Trp Val Asp Gly Ala Thr Pro
    930                 935                 940                 
Leu Phe Gly Leu Tyr Lys Arg Trp Gln Gln Arg Glu Ala Ala Leu Gln
945                 950                 955                 960 
Ala Gln Lys Ala Gln Asp Ser Tyr Gln Thr Pro Gln Asn Pro Gly Ile
                965                 970                 975     
Val Pro Arg Pro Ser Glu Leu Tyr Tyr Ser Lys Ile Gly Pro Ala Leu
            980                 985                 990         
Lys Thr Val Gly Leu Ser Leu Asp Val Ser Arg Arg Asp Trp Pro Leu
        995                 1000                1005            
His Val Met Lys Ala Val Leu Glu Glu Leu Met Glu Ala Thr Pro Pro
    1010                1015                1020                
Asn Leu Leu Ala Lys Glu Leu Trp Ser Ser Cys Thr Thr Pro Asp Glu
1025                1030                1035                1040
Trp Trp Arg Val Thr Gln Ser Tyr Ala Arg Ser Thr Ala Val Met Ser
                1045                1050                1055    
Met Val Gly Tyr Ile Ile Gly Leu Gly Asp Arg His Leu Asp Asn Val
            1060                1065                1070        
Leu Ile Asp Met Thr Thr Gly Glu Val Val His Ile Asp Tyr Asn Val
        1075                1080                1085            
Cys Phe Glu Lys Gly Lys Ser Leu Arg Val Pro Glu Lys Val Pro Phe
    1090                1095                1100                
Arg Met Thr Gln Asn Ile Glu Thr Ala Leu Gly Val Thr Gly Val Glu
1105                1110                1115                1120
Gly Val Phe Arg Leu Ser Cys Glu Gln Val Leu His Ile Met Arg Arg
                1125                1130                1135    
Gly Arg Glu Thr Leu Leu Thr Leu Leu Glu Ala Phe Val Tyr Asp Pro
            1140                1145                1150        
Leu Val Asp Trp Thr Ala Gly Gly Glu Ala Gly Phe Ala Gly Ala Val
        1155                1160                1165            
Tyr Gly Gly Gly Gly Gln Gln Ala Glu Ser Lys Gln Ser Lys Arg Glu
    1170                1175                1180                
Met Glu Arg Glu Ile Thr Arg Ser Leu Phe Ser Ser Arg Val Ala Glu
1185                1190                1195                1200
Ile Lys Val Asn Trp Phe Lys Asn Arg Asp Glu Met Leu Val Val Leu
                1205                1210                1215    
Pro Lys Leu Asp Gly Ser Leu Asp Glu Tyr Leu Ser Leu Gln Glu Gln
            1220                1225                1230        
Leu Thr Asp Val Glu Lys Leu Gln Gly Lys Leu Leu Glu Glu Ile Glu
        1235                1240                1245            
Phe Leu Glu Gly Ala Glu Gly Val Asp His Pro Ser His Thr Leu Gln
    1250                1255                1260                
His Arg Tyr Ser Glu His Thr Gln Leu Gln Thr Gln Gln Arg Ala Val
1265                1270                1275                1280
Gln Glu Ala Ile Gln Val Lys Leu Asn Glu Phe Glu Gln Trp Ile Thr
                1285                1290                1295    
His Tyr Gln Ala Ala Phe Asn Asn Leu Glu Ala Thr Gln Leu Ala Ser
            1300                1305                1310        
Leu Leu Gln Glu Ile Ser Thr Gln Met Asp Leu Gly Pro Pro Ser Tyr
        1315                1320                1325            
Val Pro Ala Thr Ala Phe Leu Gln Asn Ala Gly Gln Ala His Leu Ile
    1330                1335                1340                
Ser Gln Cys Glu Gln Leu Glu Gly Glu Val Gly Ala Leu Leu Gln Gln
1345                1350                1355                1360
Arg Arg Ser Val Leu Arg Gly Cys Leu Glu Gln Leu His His Tyr Ala
                1365                1370                1375    
Thr Val Ala Leu Gln Tyr Pro Lys Ala Ile Phe Gln Lys His Arg Ile
            1380                1385                1390        
Glu Gln Trp Lys Thr Trp Met Glu Glu Leu Ile Cys Asn Thr Thr Val
        1395                1400                1405            
Glu Arg Cys Gln Glu Leu Tyr Arg Lys Tyr Glu Met Gln Tyr Ala Pro
    1410                1415                1420                
Gln Pro Pro Pro Thr Val Cys Gln Phe Ile Thr Ala Thr Glu Met Thr
1425                1430                1435                1440
Leu Gln Arg Tyr Ala Ala Asp Ile Asn Ser Arg Leu Ile Arg Gln Val
                1445                1450                1455    
Glu Arg Leu Lys Gln Glu Ala Val Thr Val Pro Val Cys Glu Asp Gln
            1460                1465                1470        
Leu Lys Glu Ile Glu Arg Cys Ile Lys Val Phe Leu His Glu Asn Gly
        1475                1480                1485            
Glu Glu Gly Ser Leu Ser Leu Ala Ser Val Ile Ile Ser Ala Leu Cys
    1490                1495                1500                
Thr Leu Thr Arg Arg Asn Leu Met Met Glu Gly Ala Ala Ser Ser Ala
1505                1510                1515                1520
Gly Glu Gln Leu Val Asp Leu Thr Ser Arg Asp Gly Ala Trp Phe Leu
                1525                1530                1535    
Glu Glu Leu Cys Ser Met Ser Gly Asn Val Thr Cys Leu Val Gln Leu
            1540                1545                1550        
Leu Lys Gln Cys His Leu Val Pro Gln Asp Leu Asp Ile Pro Asn Pro
        1555                1560                1565            
Met Glu Ala Ser Glu Thr Val His Leu Ala Asn Gly Val Tyr Thr Ser
    1570                1575                1580                
Leu Gln Glu Leu Asn Ser Asn Phe Arg Gln Ile Ile Phe Pro Glu Ala
1585                1590                1595                1600
Leu Arg Cys Leu Met Lys Gly Glu Tyr Thr Leu Glu Ser Met Leu His
                1605                1610                1615    
Glu Leu Asp Gly Leu Ile Glu Gln Thr Thr Asp Gly Val Pro Leu Gln
            1620                1625                1630        
Thr Leu Val Glu Ser Leu Gln Ala Tyr Leu Arg Asn Ala Ala Met Gly
        1635                1640                1645            
Leu Glu Glu Glu Thr His Ala His Tyr Ile Asp Val Ala Arg Leu Leu
    1650                1655                1660                
His Ala Gln Tyr Gly Glu Leu Ile Gln Pro Arg Asn Gly Ser Val Asp
1665                1670                1675                1680
Glu Thr Pro Lys Met Ser Ala Gly Gln Met Leu Leu Val Ala Phe Asp
                1685                1690                1695    
Gly Met Phe Ala Gln Val Glu Thr Ala Phe Ser Leu Leu Val Glu Lys
            1700                1705                1710        
Leu Asn Lys Met Glu Ile Pro Ile Ala Trp Arg Lys Ile Asp Ile Ile
        1715                1720                1725            
Arg Glu Ala Arg Ser Thr Gln Val Asn Phe Phe Asp Asp Asp Asn His
    1730                1735                1740                
Arg Gln Val Leu Glu Glu Ile Phe Phe Leu Lys Arg Leu Gln Thr Ile
1745                1750                1755                1760
Lys Glu Phe Phe Arg Leu Cys Gly Thr Phe Ser Lys Thr Leu Ser Gly
                1765                1770                1775    
Ser Ser Ser Leu Glu Asp Gln Asn Thr Val Asn Gly Pro Val Gln Ile
            1780                1785                1790        
Val Asn Val Lys Thr Leu Phe Arg Asn Ser Cys Phe Ser Glu Asp Gln
        1795                1800                1805            
Met Ala Lys Pro Ile Lys Ala Phe Thr Ala Asp Phe Val Arg Gln Leu
    1810                1815                1820                
Leu Ile Gly Leu Pro Asn Gln Ala Leu Gly Leu Thr Leu Cys Ser Phe
1825                1830                1835                1840
Ile Ser Ala Leu Gly Val Asp Ile Ile Ala Gln Val Glu Ala Lys Asp
                1845                1850                1855    
Phe Gly Ala Glu Ser Lys Val Ser Val Asp Asp Leu Cys Lys Lys Ala
            1860                1865                1870        
Val Glu His Asn Ile Gln Ile Gly Lys Phe Ser Gln Leu Val Met Asn
        1875                1880                1885            
Arg Ala Thr Val Leu Ala Ser Ser Tyr Asp Thr Ala Trp Lys Lys His
    1890                1895                1900                
Asp Leu Val Arg Arg Leu Glu Thr Ser Ile Ser Ser Cys Lys Thr Ser
1905                1910                1915                1920
Leu Gln Arg Val Gln Leu His Ile Ala Met Phe Gln Trp Gln His Glu
                1925                1930                1935    
Asp Leu Leu Ile Asn Arg Pro Gln Ala Met Ser Val Thr Pro Pro Pro
            1940                1945                1950        
Arg Ser Ala Ile Leu Thr Ser Met Lys Lys Lys Leu His Thr Leu Ser
        1955                1960                1965            
Gln Ile Glu Thr Ser Ile Ala Thr Val Gln Glu Lys Leu Ala Ala Leu
    1970                1975                1980                
Glu Ser Ser Ile Glu Gln Arg Leu Lys Trp Ala Gly Gly Ala Asn Pro
1985                1990                1995                2000
Ala Leu Ala Pro Val Leu Gln Asp Phe Glu Ala Thr Ile Ala Glu Arg
                2005                2010                2015    
Arg Asn Leu Val Leu Lys Glu Ser Gln Arg Ala Ser Gln Val Thr Phe
            2020                2025                2030        
Leu Cys Ser Asn Ile Ile His Phe Glu Ser Leu Arg Thr Arg Thr Ala
        2035                2040                2045            
Glu Ala Leu Asn Leu Asp Ala Ala Leu Phe Glu Leu Ile Lys Arg Cys
    2050                2055                2060                
Gln Gln Met Cys Ser Phe Ala Ser Gln Phe Asn Ser Ser Val Ser Glu
2065                2070                2075                2080
Leu Glu Leu Arg Leu Leu Gln Arg Val Asp Thr Gly Leu Glu His Pro
                2085                2090                2095    
Ile Gly Ser Ser Glu Trp Leu Leu Ser Ala His Lys Gln Leu Thr Gln
            2100                2105                2110        
Asp Met Ser Thr Gln Arg Ala Ile Gln Thr Glu Lys Glu Gln Gln Ile
        2115                2120                2125            
Glu Thr Val Cys Glu Thr Ile Gln Asn Leu Val Asp Asn Ile Lys Thr
    2130                2135                2140                
Val Leu Thr Gly His Asn Arg Gln Leu Gly Asp Val Lys His Leu Leu
2145                2150                2155                2160
Lys Ala Met Ala Lys Asp Glu Glu Ala Ala Leu Ala Asp Gly Glu Asp
                2165                2170                2175    
Val Pro Tyr Glu Asn Ser Val Arg Gln Phe Leu Gly Glu Tyr Lys Ser
            2180                2185                2190        
Trp Gln Asp Asn Ile Gln Thr Val Leu Phe Thr Leu Val Gln Ala Met
        2195                2200                2205            
Gly Gln Val Arg Ser Gln Glu His Val Glu Met Leu Gln Glu Ile Thr
    2210                2215                2220                
Pro Thr Leu Lys Glu Leu Lys Thr Gln Ser Gln Ser Ile Tyr Asn Asn
2225                2230                2235                2240
Leu Val Ser Phe Ala Ser Pro Leu Val Thr Asp Ala Thr Asn Glu Cys
                2245                2250                2255    
Ser Ser Pro Thr Ser Ser Ala Thr Tyr Gln Pro Ser Phe Ala Ala Ala
            2260                2265                2270        
Val Arg Ser Asn Thr Gly Gln Lys Thr Gln Pro Asp Val Met Ser Gln
        2275                2280                2285            
Asn Ala Arg Lys Leu Ile Gln Lys Asn Leu Ala Thr Ser Ala Asp Thr
    2290                2295                2300                
Pro Pro Ser Thr Val Pro Gly Thr Gly Lys Ser Val Ala Cys Ser Pro
2305                2310                2315                2320
Lys Lys Ala Val Arg Asp Pro Lys Thr Gly Lys Ala Val Gln Glu Arg
                2325                2330                2335    
Asn Ser Tyr Ala Val Ser Val Trp Lys Arg Val Lys Ala Lys Leu Glu
            2340                2345                2350        
Gly Arg Asp Val Asp Pro Asn Arg Arg Met Ser Val Ala Glu Gln Val
        2355                2360                2365            
Asp Tyr Val Ile Lys Glu Ala Thr Asn Leu Asp Asn Leu Ala Gln Leu
    2370                2375                2380                
Tyr Glu Gly Trp Thr Ala Trp Val
2385                2390        


<210> 1881
<211> 175
<212> PRT
<213> Homo sapiens

<400> 1881
Thr Leu Gln Ala Ser Phe Leu Thr Lys Lys Leu Asn Ile Gly Gly Lys
 1               5                  10                  15      
Arg Val Asn Leu Ala Ile Trp Asp Thr Ala Gly Gln Glu Arg Phe His
            20                  25                  30          
Ala Leu Gly Pro Ile Tyr Tyr Arg Asp Ser Asn Gly Ala Ile Leu Val
        35                  40                  45              
Tyr Asp Ile Thr Asp Glu Asp Ser Phe Gln Lys Val Lys Asn Trp Val
    50                  55                  60                  
Lys Glu Leu Arg Lys Met Leu Gly Asn Glu Ile Cys Leu Cys Ile Val
65                  70                  75                  80  
Gly Asn Lys Ile Asp Leu Glu Lys Glu Arg His Val Ser Ile Gln Glu
                85                  90                  95      
Ala Glu Ser Tyr Ala Glu Ser Val Gly Ala Lys His Tyr His Thr Ser
            100                 105                 110         
Ala Lys Gln Asn Lys Gly Ile Glu Glu Leu Phe Leu Asp Leu Cys Lys
        115                 120                 125             
Arg Met Ile Glu Thr Ala Gln Val Asp Glu Arg Ala Lys Gly Asn Gly
    130                 135                 140                 
Ser Ser Gln Pro Gly Thr Ala Arg Arg Gly Val Gln Ile Ile Asp Asp
145                 150                 155                 160 
Glu Pro Gln Ala Gln Thr Ser Gly Gly Gly Cys Cys Ser Ser Gly
                165                 170                 175 


<210> 1882
<211> 1172
<212> PRT
<213> Homo sapiens

<400> 1882
Phe Met Ser Met Phe Gln Ile Leu Thr Gln Glu Gly Trp Val Asp Val
 1               5                  10                  15      
Met Asp Gln Thr Leu Asn Ala Val Gly His Met Trp Ala Pro Val Val
            20                  25                  30          
Ala Ile Tyr Phe Ile Leu Tyr His Leu Phe Ala Thr Leu Ile Leu Leu
        35                  40                  45              
Ser Leu Phe Val Ala Val Ile Leu Asp Asn Leu Glu Leu Asp Glu Asp
    50                  55                  60                  
Leu Lys Lys Leu Lys Gln Leu Lys Gln Ser Glu Ala Asn Ala Asp Thr
65                  70                  75                  80  
Lys Glu Lys Leu Pro Leu Arg Leu Arg Ile Phe Glu Lys Phe Pro Asn
                85                  90                  95      
Arg Pro Gln Met Val Lys Ile Ser Lys Leu Pro Ser Asp Phe Thr Val
            100                 105                 110         
Pro Lys Ile Arg Glu Ser Phe Met Lys Gln Phe Ile Asp Arg Gln Gln
        115                 120                 125             
Gln Asp Thr Cys Cys Leu Leu Arg Ser Leu Pro Thr Thr Ser Ser Ser
    130                 135                 140                 
Ser Cys Asp His Ser Lys Arg Ser Ala Ile Glu Asp Asn Lys Tyr Ile
145                 150                 155                 160 
Asp Gln Lys Leu Arg Lys Ser Val Phe Ser Ile Arg Ala Arg Asn Leu
                165                 170                 175     
Leu Glu Lys Glu Thr Ala Val Thr Lys Ile Leu Arg Ala Cys Thr Arg
            180                 185                 190         
Gln Arg Met Leu Ser Gly Ser Phe Glu Gly Gln Pro Ala Lys Glu Arg
        195                 200                 205             
Ser Ile Leu Ser Val Gln His His Ile Arg Gln Glu Arg Arg Ser Leu
    210                 215                 220                 
Arg His Gly Ser Asn Ser Gln Arg Ile Ser Arg Gly Lys Ser Leu Glu
225                 230                 235                 240 
Thr Leu Thr Gln Asp His Ser Asn Thr Val Arg Tyr Arg Asn Ala Gln
                245                 250                 255     
Arg Glu Asp Ser Glu Ile Lys Met Ile Gln Glu Lys Lys Glu Gln Ala
            260                 265                 270         
Glu Met Lys Arg Lys Val Gln Glu Glu Glu Leu Arg Glu Asn His Pro
        275                 280                 285             
Tyr Phe Asp Lys Pro Leu Phe Ile Val Gly Arg Glu His Arg Phe Arg
    290                 295                 300                 
Asn Phe Cys Arg Val Val Val Arg Ala Arg Phe Asn Ala Ser Lys Thr
305                 310                 315                 320 
Asp Pro Val Thr Gly Ala Val Lys Asn Thr Lys Tyr His Gln Leu Tyr
                325                 330                 335     
Asp Leu Leu Gly Leu Val Thr Tyr Leu Asp Trp Val Met Ile Ile Val
            340                 345                 350         
Thr Ile Cys Ser Cys Ile Ser Met Met Phe Glu Ser Pro Phe Arg Arg
        355                 360                 365             
Val Met His Ala Pro Thr Leu Gln Ile Ala Glu Tyr Val Phe Val Ile
    370                 375                 380                 
Phe Met Ser Ile Glu Leu Asn Leu Lys Ile Met Ala Asp Gly Leu Phe
385                 390                 395                 400 
Phe Thr Pro Thr Ala Val Ile Arg Asp Phe Gly Gly Val Met Asp Ile
                405                 410                 415     
Phe Ile Tyr Leu Val Ser Leu Ile Phe Leu Cys Trp Met Pro Gln Asn
            420                 425                 430         
Val Pro Ala Glu Ser Gly Ala Gln Leu Leu Met Val Leu Arg Cys Leu
        435                 440                 445             
Arg Pro Leu Arg Ile Phe Lys Leu Val Pro Gln Met Arg Lys Val Val
    450                 455                 460                 
Arg Glu Leu Phe Ser Gly Phe Lys Glu Ile Phe Leu Val Ser Ile Leu
465                 470                 475                 480 
Leu Leu Thr Leu Met Leu Val Phe Ala Ser Phe Gly Val Gln Leu Phe
                485                 490                 495     
Ala Gly Lys Leu Ala Lys Cys Asn Asp Pro Asn Ile Ile Arg Arg Glu
            500                 505                 510         
Asp Cys Asn Gly Ile Phe Arg Ile Asn Val Ser Val Ser Lys Asn Leu
        515                 520                 525             
Asn Leu Lys Leu Arg Pro Gly Glu Lys Lys Pro Gly Phe Trp Val Pro
    530                 535                 540                 
Arg Val Trp Ala Asn Pro Arg Asn Phe Asn Phe Asp Asn Val Gly Asn
545                 550                 555                 560 
Ala Met Leu Ala Leu Phe Glu Val Leu Ser Leu Lys Gly Trp Val Glu
                565                 570                 575     
Val Arg Asp Val Ile Ile His Arg Val Gly Pro Ile His Gly Ile Tyr
            580                 585                 590         
Ile His Val Phe Val Phe Leu Gly Cys Met Ile Gly Leu Thr Leu Phe
        595                 600                 605             
Val Gly Val Val Ile Ala Asn Phe Asn Glu Asn Lys Gly Thr Ala Leu
    610                 615                 620                 
Leu Thr Val Asp Gln Arg Arg Trp Glu Asp Leu Lys Ser Arg Leu Lys
625                 630                 635                 640 
Ile Ala Gln Pro Leu His Leu Pro Pro Arg Pro Asp Asn Asp Gly Phe
                645                 650                 655     
Arg Ala Lys Met Tyr Asp Ile Thr Gln His Pro Phe Phe Lys Arg Thr
            660                 665                 670         
Ile Ala Leu Leu Val Leu Ala Gln Ser Val Leu Leu Ser Val Lys Trp
        675                 680                 685             
Asp Val Glu Asp Pro Val Thr Val Pro Leu Ala Thr Met Ser Val Val
    690                 695                 700                 
Phe Thr Phe Ile Phe Val Leu Glu Val Thr Met Lys Ile Ile Ala Met
705                 710                 715                 720 
Ser Pro Ala Gly Phe Trp Gln Ser Arg Arg Asn Arg Tyr Asp Leu Leu
                725                 730                 735     
Val Thr Ser Leu Gly Val Val Trp Val Val Leu His Phe Ala Leu Leu
            740                 745                 750         
Val Thr Leu Lys Met Leu Leu Leu Thr Val Val Val Ser Met Tyr Lys
        755                 760                 765             
Ser Phe Phe Ile Ile Val Gly Met Phe Leu Leu Leu Leu Cys Tyr Ala
    770                 775                 780                 
Phe Ala Gly Val Val Leu Phe Gly Thr Val Lys Tyr Gly Glu Asn Ile
785                 790                 795                 800 
Asn Arg His Ala Asn Phe Ser Ser Ala Gly Lys Ala Ile Thr Val Leu
                805                 810                 815     
Phe Arg Ile Val Thr Gly Glu Asp Trp Asn Lys Ile Met His Asp Cys
            820                 825                 830         
Met Val Gln Pro Pro Phe Cys Thr Pro Asp Glu Phe Thr Tyr Trp Ala
        835                 840                 845             
Thr Asp Cys Gly Asn Tyr Ala Gly Ala Leu Met Tyr Phe Cys Ser Phe
    850                 855                 860                 
Tyr Val Ile Ile Ala Tyr Ile Met Leu Asn Leu Leu Val Ala Ile Ile
865                 870                 875                 880 
Val Glu Asn Phe Ser Leu Phe Tyr Ser Thr Glu Glu Asp Gln Leu Leu
                885                 890                 895     
Ser Tyr Asn Asp Leu Arg His Phe Gln Ile Ile Trp Asn Met Val Asp
            900                 905                 910         
Asp Lys Arg Glu Gly Val Ile Pro Thr Phe Arg Val Lys Phe Leu Leu
        915                 920                 925             
Arg Leu Leu Arg Gly Arg Leu Glu Val Asp Leu Asp Lys Asp Lys Leu
    930                 935                 940                 
Leu Phe Lys His Met Cys Tyr Glu Met Glu Arg Leu His Asn Gly Gly
945                 950                 955                 960 
Asp Val Thr Phe His Asp Val Leu Ser Met Leu Ser Tyr Arg Ser Val
                965                 970                 975     
Asp Ile Arg Lys Ser Leu Gln Leu Glu Glu Leu Leu Ala Arg Glu Gln
            980                 985                 990         
Leu Glu Tyr Thr Ile Glu Glu Glu Val Ala Lys Gln Thr Ile Arg Met
        995                 1000                1005            
Trp Leu Lys Lys Cys Leu Lys Arg Ile Arg Ala Lys Gln Gln Gln Ser
    1010                1015                1020                
Cys Ser Ile Ile His Ser Leu Arg Glu Ser Gln Gln Gln Glu Leu Ser
1025                1030                1035                1040
Arg Phe Leu Asn Pro Pro Ser Ile Glu Thr Thr Gln Pro Ser Glu Asp
                1045                1050                1055    
Thr Asn Ala Asn Ser Gln Asp Asn Ser Met Gln Pro Glu Thr Ser Ser
            1060                1065                1070        
Gln Gln Gln Leu Leu Ser Pro Thr Leu Ser Asp Arg Gly Gly Ser Arg
        1075                1080                1085            
Gln Asp Ala Ala Asp Ala Gly Lys Pro Gln Arg Lys Phe Gly Gln Trp
    1090                1095                1100                
Arg Leu Pro Ser Ala Pro Lys Pro Ile Ser His Ser Val Ser Ser Val
1105                1110                1115                1120
Asn Leu Arg Phe Gly Gly Arg Thr Thr Met Lys Ser Val Val Cys Lys
                1125                1130                1135    
Met Asn Pro Met Thr Asp Ala Ala Ser Cys Gly Ser Glu Val Lys Lys
            1140                1145                1150        
Trp Trp Thr Arg Gln Leu Thr Val Glu Ser Asp Glu Ser Gly Asp Asp
        1155                1160                1165            
Leu Leu Asp Ile
    1170        


<210> 1883
<211> 372
<212> PRT
<213> Homo sapiens

<400> 1883
Leu Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Thr Asn Ala Ala Ile
 1               5                  10                  15      
Ala Glu Ala Met Lys Val Lys Lys Ile Lys Leu Glu Ala Met Ser Asn
            20                  25                  30          
Tyr His Ala Ser Asn Asn Gln His Gly Ala Asp Ser Glu Asn Gly Asp
        35                  40                  45              
Met Asn Ser Ser Val Gly Leu Glu Leu Pro Phe Met Met Met Pro His
    50                  55                  60                  
Pro Leu Ile Pro Val Ser Leu Pro Pro Ala Ser Val Thr Met Ala Met
65                  70                  75                  80  
Ser Gln Met Asn His Leu Ser Thr Ile Ala Asn Met Ala Ala Ala Ala
                85                  90                  95      
Gln Val Gln Ser Pro Pro Ser Arg Val Glu Thr Ser Val Ile Lys Glu
            100                 105                 110         
Arg Val Pro Asp Ser Pro Ser Pro Ala Pro Ser Leu Glu Glu Gly Arg
        115                 120                 125             
Arg Pro Gly Ser His Pro Ser Ser His Arg Ser Ser Ser Val Ser Ser
    130                 135                 140                 
Ser Pro Ala Arg Thr Glu Ser Ser Ser Asp Arg Ile Pro Val His Gln
145                 150                 155                 160 
Asn Gly Leu Ser Met Asn Gln Met Leu Met Gly Leu Ser Pro Asn Val
                165                 170                 175     
Leu Pro Gly Pro Lys Glu Gly Asp Leu Ala Gly His Asp Met Gly His
            180                 185                 190         
Glu Ser Lys Arg Met His Ile Glu Lys Asp Glu Thr Pro Leu Ser Thr
        195                 200                 205             
Pro Thr Ala Arg Asp Ser Leu Asp Lys Leu Ser Leu Thr Gly His Gly
    210                 215                 220                 
Gln Pro Leu Pro Pro Gly Phe Pro Ser Pro Phe Leu Phe Pro Asp Gly
225                 230                 235                 240 
Leu Ser Ser Ile Glu Thr Leu Leu Thr Asn Ile Gln Gly Leu Leu Lys
                245                 250                 255     
Val Ala Ile Asp Asn Ala Arg Ala Gln Glu Lys Gln Val Gln Leu Glu
            260                 265                 270         
Lys Thr Glu Leu Lys Met Asp Phe Leu Arg Glu Arg Glu Leu Arg Glu
        275                 280                 285             
Thr Leu Glu Lys Gln Leu Ala Met Glu Gln Lys Asn Arg Ala Ile Val
    290                 295                 300                 
Gln Lys Arg Leu Lys Lys Glu Lys Lys Ala Lys Arg Lys Leu Gln Glu
305                 310                 315                 320 
Ala Leu Glu Phe Glu Thr Lys Arg Arg Glu Gln Ala Glu Gln Thr Leu
                325                 330                 335     
Lys Gln Ala Ala Ser Thr Asp Ser Leu Arg Val Leu Asn Asp Ser Leu
            340                 345                 350         
Thr Pro Glu Ile Glu Ala Asp Arg Ser Gly Gly Arg Thr Asp Ala Glu
        355                 360                 365             
Arg Thr Ile Gln
    370         


<210> 1884
<211> 402
<212> PRT
<213> Homo sapiens

<400> 1884
Met Ala Arg Thr Asp Gln Lys Pro Pro Cys Arg Gly Gly Cys Trp Gly
 1               5                  10                  15      
Gln Pro Gly His Pro Asn Thr Gly Gly Ala Ala Ala His Pro Thr Tyr
            20                  25                  30          
His Pro Met Gly His Arg Pro Arg Thr Cys Ile Leu Leu Arg Gly Asp
        35                  40                  45              
Gln Thr Thr Gly Gly Gln Ala Pro Ser Arg Glu Ile Ser Leu Gly Pro
    50                  55                  60                  
Trp Ala Ala Gly Thr His Phe Leu Ala Ile Ser Thr Thr Pro Trp Gly
65                  70                  75                  80  
Arg Lys Thr Pro Ala Cys Ile Ser Glu Leu Pro Thr Ser Ser Gly Thr
                85                  90                  95      
Ala Gln Pro Leu Ala Asn Ala Val Cys Glu Val Gln Thr Val Pro Gly
            100                 105                 110         
Pro Gly Leu Arg Pro Gln Gly Thr Pro Ala Met Arg Ala Pro Ser His
        115                 120                 125             
Lys Gly Thr Pro Pro Thr Pro Asn Pro Trp Gly Pro Glu Gln Pro Gln
    130                 135                 140                 
Asn Arg His Lys His Pro Lys Lys Gly Val Thr Gly Gly Pro Ser Pro
145                 150                 155                 160 
Pro Pro Pro Ala Ala Ser Arg Tyr Gly Gln Thr Pro Gly Arg Glu Pro
                165                 170                 175     
Arg Val Gln Ala Pro Gly Leu Gly Pro Cys Gly Arg Pro Ala Ser Gly
            180                 185                 190         
Arg Leu Leu Ser Leu His Leu Glu Lys Gly Asp Gly Lys Gly Thr Arg
        195                 200                 205             
Gln Arg Ile Pro Leu Thr Asp Ala Ala Val Gly Gly Asp Arg Thr Asp
    210                 215                 220                 
Ile Pro Ser Ala Ile Ala Ala Gly Pro Ala Arg Thr Pro Asp Arg His
225                 230                 235                 240 
Gly Leu Pro Ile Pro Gly Ser Thr Pro Thr Pro Met Val Gly Ser Gly
                245                 250                 255     
Arg Leu Gly Ala Pro Val Gly Arg Ser Gly Gly Gly Ala Ser Ala Arg
            260                 265                 270         
Ser Ser Arg Pro Ser Cys Ala Asn Val Leu Leu Arg Ala Asp Ala Ser
        275                 280                 285             
Leu Gly Thr Val Leu Ser Val Leu Trp Thr Gly Gln Leu Ser Arg Gly
    290                 295                 300                 
Trp Ala Leu Leu Pro Pro Gly Asp Ala Gly Arg His Leu Glu Thr Ser
305                 310                 315                 320 
Val Ile Ser Ala Gly Val Ala Ala Gly Ile Trp Leu Val Glu Pro Gly
                325                 330                 335     
Glu Ala Ala Gln Asp Pro Ala Thr Arg Arg Thr Ala Pro Pro Arg Arg
            340                 345                 350         
Thr Ala Ser Pro Glu Pro Pro Ala Pro Gly Ala Pro Leu Pro Ala Cys
        355                 360                 365             
Pro Gly Arg Ile Pro Gly Ala Ala Arg Phe Gly Pro Arg Ser Cys Pro
    370                 375                 380                 
Leu Gly Ser Pro Ala Val Leu Ala Val Thr Thr Gly Trp Ser His Arg
385                 390                 395                 400 
Ser Val
        


<210> 1885
<211> 299
<212> PRT
<213> Homo sapiens

<400> 1885
Met Thr Val Glu Glu Lys Gly Gly Phe Lys Ala Ala Phe Glu Thr Leu
 1               5                  10                  15      
Ser Phe Ser Tyr Gln Val Phe Ser Ile Glu Leu Glu Gly Ser Glu Leu
            20                  25                  30          
Ala Trp Asp Ile Gly Ser Glu Arg Tyr Thr Phe Ser Phe Thr Ile Arg
        35                  40                  45              
Asp Ser Pro Ala His Phe Val Asn Ala Ala Ser Trp Gly Asn Glu Asp
    50                  55                  60                  
Tyr Ile Lys Ser Leu Ser Asp Ser Phe Arg Val Gly Asp Cys Val Ile
65                  70                  75                  80  
Ile Glu Asn Pro Leu Ile Gln Arg Lys Glu Ile Glu Arg Glu Glu Lys
                85                  90                  95      
Phe Ser Pro Ala Thr Pro Ser Asn Cys Lys Leu Leu Leu Ser Glu Asn
            100                 105                 110         
His Ser Thr Val Lys Val Cys Ser Ser Tyr Glu Val Asp Thr Lys Leu
        115                 120                 125             
Leu Ser Leu Ile His Leu Pro Val Lys Glu Ser His Asp Tyr Tyr Ser
    130                 135                 140                 
Leu Gly Asp Ile Val Ala Asn Gly His Ser Leu Asn Gly Arg Ile Ile
145                 150                 155                 160 
Asn Val Leu Ala Ala Val Lys Ser Val Pro Phe Ser Gly His His Arg
                165                 170                 175     
Cys Ser Gly Gly Arg Val Ile Phe Ala Ser Asp Val Arg Ile Asn Phe
            180                 185                 190         
Asp Lys Phe Arg Asn Cys Met Thr Ala Thr Val Ile Ser Lys Thr Ile
        195                 200                 205             
Ile Thr Thr Asn Pro Asp Ile Pro Glu Ala Asn Ile Leu Leu Asn Phe
    210                 215                 220                 
Ile Arg Glu Asn Lys Glu Thr Asn Val Leu Asp Asp Glu Ile Asp Ser
225                 230                 235                 240 
Tyr Phe Lys Glu Ser Ile Asn Leu Ser Thr Ile Val Asp Val Tyr Thr
                245                 250                 255     
Val Glu Gln Leu Lys Gly Lys Ala Leu Lys Asn Glu Gly Lys Ala Asp
            260                 265                 270         
Pro Ser Tyr Gly Ile Leu Tyr Ala Tyr Ile Ser Thr Leu Asn Ile Asp
        275                 280                 285             
Asp Glu Thr Thr Lys Val Val Arg Asn Arg Trp
    290                 295                 


<210> 1886
<211> 43
<212> PRT
<213> Homo sapiens

<400> 1886
Met Pro Asp Ser Trp Asp Lys Asp Val Tyr Pro Glu Pro Pro Arg Arg
 1               5                  10                  15      
Thr Pro Val Gln Pro Asn Pro Ile Val Tyr Met Met Lys Ala Phe Asp
            20                  25                  30          
Leu Ile Val Asp Arg Pro Val Thr Leu Val Arg
        35                  40              


<210> 1887
<211> 442
<212> PRT
<213> Homo sapiens

<400> 1887
Met Ala Pro Arg Ser Leu Leu Leu Leu Leu Ser Gly Ala Leu Ala Leu
 1               5                  10                  15      
Thr Asp Thr Trp Ala Gly Ser His Ser Leu Arg Tyr Phe Ser Thr Ala
            20                  25                  30          
Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Tyr Ile Ala Val Glu Tyr
        35                  40                  45              
Val Asp Asp Thr Gln Phe Leu Arg Phe Asp Ser Asp Ala Ala Ile Pro
    50                  55                  60                  
Arg Met Glu Pro Arg Glu Pro Trp Val Glu Gln Glu Gly Pro Gln Tyr
65                  70                  75                  80  
Trp Glu Trp Thr Thr Gly Tyr Ala Lys Ala Asn Ala Gln Thr Asp Arg
                85                  90                  95      
Val Ala Leu Arg Asn Leu Leu Arg Arg Tyr Asn Gln Ser Glu Ala Gly
            100                 105                 110         
Ser His Thr Leu Gln Gly Met Asn Gly Cys Asp Met Gly Pro Asp Gly
        115                 120                 125             
Arg Leu Leu Arg Gly Tyr His Gln His Ala Tyr Asp Gly Lys Asp Tyr
    130                 135                 140                 
Ile Ser Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Val
145                 150                 155                 160 
Ala Gln Ile Thr Gln Arg Phe Tyr Glu Ala Glu Glu Tyr Ala Glu Glu
                165                 170                 175     
Phe Arg Thr Tyr Leu Glu Gly Glu Cys Leu Glu Leu Leu Arg Arg Tyr
            180                 185                 190         
Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro Pro Lys Ala
        195                 200                 205             
His Val Ala His His Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys
    210                 215                 220                 
Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg
225                 230                 235                 240 
Asp Gly Glu Glu Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro
                245                 250                 255     
Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser
            260                 265                 270         
Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro
        275                 280                 285             
Gln Pro Leu Ile Leu Arg Trp Glu Gln Ser Pro Gln Pro Thr Ile Pro
    290                 295                 300                 
Ile Val Gly Ile Val Ala Gly Leu Val Val Leu Gly Ala Val Val Thr
305                 310                 315                 320 
Gly Ala Val Val Ala Ala Val Met Trp Arg Lys Lys Ser Ser Asp Arg
                325                 330                 335     
Asn Arg Gly Ser Tyr Ser Gln Ala Ala Ala Tyr Ser Val Val Ser Gly
            340                 345                 350         
Leu Leu Met Ile Thr Trp Trp Ser Ser Leu Phe Leu Leu Gly Val Leu
        355                 360                 365             
Phe Gln Gly Tyr Leu Gly Cys Leu Arg Ser His Ser Val Leu Gly Arg
    370                 375                 380                 
Arg Lys Val Gly Asp Met Trp Ile Leu Phe Phe Leu Trp Leu Trp Thr
385                 390                 395                 400 
Ser Phe Asn Thr Ala Phe Leu Ala Leu Gln Ser Leu Arg Phe Gly Phe
                405                 410                 415     
Gly Phe Arg Arg Gly Arg Ser Phe Leu Leu Arg Ser Trp His His Leu
            420                 425                 430         
Met Lys Arg Val Gln Ile Lys Ile Phe Asp
        435                 440         


<210> 1888
<211> 359
<212> PRT
<213> Homo sapiens

<400> 1888
Met Pro Ser Leu Leu Leu Leu Phe Thr Ala Ala Leu Leu Ser Ser Trp
 1               5                  10                  15      
Ala Gln Leu Leu Thr Asp Ala Asn Ser Trp Trp Ser Leu Ala Leu Asn
            20                  25                  30          
Pro Val Gln Arg Pro Glu Met Phe Ile Ile Gly Ala Gln Pro Val Cys
        35                  40                  45              
Ser Gln Leu Pro Gly Leu Ser Pro Gly Gln Arg Lys Leu Cys Gln Leu
    50                  55                  60                  
Tyr Gln Glu His Met Ala Tyr Ile Arg Glu Gly Ala Lys Thr Gly Ile
65                  70                  75                  80  
Lys Glu Cys Gln His Gln Phe Pro Gln Arg Arg Trp Lys Cys Ser Thr
                85                  90                  95      
Ala Asp Asn Ala Ser Val Phe Gly Arg Val Met Gln Ile Gly Ser Arg
            100                 105                 110         
Glu Thr Ala Phe Thr His Ala Val Ser Ala Ala Gly Val Val Asn Ala
        115                 120                 125             
Ile Ser Arg Ala Cys Ser Glu Gly Glu Leu Ser Thr Cys Gly Cys Ser
    130                 135                 140                 
Arg Thr Ala Arg Pro Lys Asp Leu Pro Arg Asp Trp Leu Trp Gly Gly
145                 150                 155                 160 
Cys Gly Asp Asn Val Glu Tyr Gly Tyr Arg Phe Ala Lys Glu Phe Val
                165                 170                 175     
Asp Ala Arg Glu Arg Glu Lys Asn Phe Ala Lys Gly Ser Glu Glu Gln
            180                 185                 190         
Gly Arg Val Leu Met Asn Leu Gln Asn Asn Glu Ala Gly Arg Arg Ala
        195                 200                 205             
Val Tyr Lys Met Ala Asp Val Ala Cys Lys Cys His Gly Val Ser Arg
    210                 215                 220                 
Ser Cys Arg Leu Lys Thr Cys Trp Leu Gln Leu Ala Glu Phe Arg Lys
225                 230                 235                 240 
Val Gly Asp Arg Leu Lys Glu Lys Tyr Asp Ser Ala Ala Ala Met Arg
                245                 250                 255     
Val Thr Arg Lys Gly Arg Leu Glu Leu Val Asn Ser Arg Phe Thr Gln
            260                 265                 270         
Pro Thr Pro Glu Asp Leu Val Tyr Val Asp Pro Ser Pro Asp Tyr Cys
        275                 280                 285             
Leu Arg Asn Glu Ser Thr Gly Ser Leu Gly Thr Gln Gly Arg Leu Cys
    290                 295                 300                 
Asn Lys Thr Ser Glu Gly Met Asp Gly Cys Glu Leu Met Cys Cys Gly
305                 310                 315                 320 
Arg Gly Tyr Asn Gln Phe Lys Ser Val Gln Val Glu Arg Cys His Cys
                325                 330                 335     
Lys Phe His Trp Cys Cys Phe Val Arg Cys Lys Lys Cys Thr Glu Ile
            340                 345                 350         
Val Asp Gln Tyr Ile Cys Lys
        355                 


<210> 1889
<211> 373
<212> PRT
<213> Homo sapiens

<400> 1889
Ala Arg Gly Val Arg Ala Leu Trp Pro Gly Gly Cys Ala Leu Ala Trp
 1               5                  10                  15      
Arg Leu Gly Gly Arg Pro Gln Pro Leu Leu Pro Thr Gln Ser Arg Ala
            20                  25                  30          
Gly Phe Ala Gly Ala Ala Gly Gly Pro Ser Pro Val Ala Ala Ala Arg
        35                  40                  45              
Lys Gly Ser Pro Arg Leu Leu Gly Ala Ala Ala Leu Ala Leu Gly Gly
    50                  55                  60                  
Ala Leu Gly Leu Tyr His Thr Ala Arg Trp His Leu Arg Ala Gln Asp
65                  70                  75                  80  
Leu His Ala Glu Arg Ser Ala Ala Gln Leu Ser Leu Ser Ser Arg Leu
                85                  90                  95      
Gln Leu Thr Leu Tyr Gln Tyr Lys Thr Cys Pro Phe Cys Ser Lys Val
            100                 105                 110         
Arg Ala Phe Leu Asp Phe His Ala Leu Pro Tyr Gln Val Val Glu Val
        115                 120                 125             
Asn Pro Val Arg Arg Ala Glu Ile Lys Phe Ser Ser Tyr Arg Lys Val
    130                 135                 140                 
Pro Ile Leu Val Ala Gln Glu Gly Glu Ser Ser Gln Gln Leu Asn Asp
145                 150                 155                 160 
Ser Ser Val Ile Ile Ser Ala Leu Lys Thr Tyr Leu Val Ser Gly Gln
                165                 170                 175     
Pro Leu Glu Glu Ile Ile Thr Tyr Tyr Pro Ala Met Lys Ala Val Asn
            180                 185                 190         
Glu Gln Gly Lys Glu Val Thr Glu Phe Gly Asn Lys Tyr Trp Leu Met
        195                 200                 205             
Leu Asn Glu Lys Glu Ala Gln Gln Val Tyr Gly Gly Lys Glu Ala Arg
    210                 215                 220                 
Thr Glu Glu Met Lys Trp Arg Gln Trp Ala Asp Asp Trp Leu Val His
225                 230                 235                 240 
Leu Ile Ser Pro Asn Val Tyr Arg Thr Pro Thr Glu Ala Leu Ala Ser
                245                 250                 255     
Phe Asp Tyr Ile Val Arg Glu Gly Lys Phe Gly Ala Val Glu Gly Ala
            260                 265                 270         
Val Ala Lys Tyr Met Gly Ala Ala Ala Met Tyr Leu Ile Ser Lys Arg
        275                 280                 285             
Leu Lys Ser Arg His Arg Leu Gln Asp Asn Val Arg Glu Asp Leu Tyr
    290                 295                 300                 
Glu Ala Ala Asp Lys Trp Val Ala Ala Val Gly Lys Asp Arg Pro Phe
305                 310                 315                 320 
Met Gly Gly Gln Lys Pro Asn Leu Ala Asp Leu Ala Val Tyr Gly Val
                325                 330                 335     
Leu Arg Val Met Glu Gly Leu Asp Ala Phe Asp Asp Leu Met Gln His
            340                 345                 350         
Thr His Ile Gln Pro Trp Tyr Leu Arg Val Glu Arg Ala Ile Thr Glu
        355                 360                 365             
Ala Ser Pro Ala His
    370             


<210> 1890
<211> 62
<212> PRT
<213> Homo sapiens

<400> 1890
Phe Cys Ala Leu Gly Asp Arg Ile Leu Gly Ala Gly Gly Thr Asp Lys
 1               5                  10                  15      
Leu Ile Phe Gly Lys Gly Thr Arg Val Thr Val Glu Pro Arg Ser Gln
            20                  25                  30          
Pro His Thr Lys Pro Ser Val Phe Val Met Lys Asn Gly Thr Asn Val
        35                  40                  45              
Ala Cys Leu Val Lys Glu Phe Tyr Pro Lys Asp Ile Arg Ile
    50                  55                  60          


<210> 1891
<211> 557
<212> PRT
<213> Homo sapiens

<400> 1891
Ala Ala Leu Thr Arg Asp Pro Gln Phe Gln Lys Leu Gln Gln Trp Tyr
 1               5                  10                  15      
Arg Glu His Arg Ser Glu Leu Asn Leu Arg Arg Leu Phe Asp Ala Asn
            20                  25                  30          
Lys Asp Arg Phe Asn His Phe Ser Leu Thr Leu Asn Thr Asn His Gly
        35                  40                  45              
His Ile Leu Val Asp Tyr Ser Lys Asn Leu Val Thr Glu Asp Val Met
    50                  55                  60                  
Arg Met Leu Val Asp Leu Ala Lys Ser Arg Gly Val Glu Ala Ala Arg
65                  70                  75                  80  
Glu Arg Met Phe Asn Gly Glu Lys Ile Asn Tyr Thr Glu Gly Arg Ala
                85                  90                  95      
Val Leu His Val Ala Leu Arg Asn Arg Ser Asn Thr Pro Ile Leu Val
            100                 105                 110         
Asp Gly Lys Asp Val Met Pro Glu Val Asn Lys Val Leu Asp Lys Met
        115                 120                 125             
Lys Ser Phe Cys Gln Arg Val Arg Ser Gly Asp Trp Lys Gly Tyr Thr
    130                 135                 140                 
Gly Lys Thr Ile Thr Asp Val Ile Asn Ile Gly Ile Gly Gly Ser Asp
145                 150                 155                 160 
Leu Gly Pro Leu Met Val Thr Glu Ala Leu Lys Pro Tyr Ser Ser Gly
                165                 170                 175     
Gly Pro Arg Val Trp Tyr Val Ser Asn Ile Asp Gly Thr His Ile Ala
            180                 185                 190         
Lys Thr Leu Ala Gln Leu Asn Pro Glu Ser Ser Leu Phe Ile Ile Ala
        195                 200                 205             
Ser Lys Thr Phe Thr Thr Gln Glu Thr Ile Thr Asn Ala Glu Thr Ala
    210                 215                 220                 
Lys Glu Trp Phe Leu Gln Ala Ala Lys Asp Pro Ser Ala Val Ala Lys
225                 230                 235                 240 
His Phe Val Ala Leu Ser Thr Asn Thr Thr Lys Val Lys Glu Phe Gly
                245                 250                 255     
Ile Asp Pro Gln Asn Met Phe Glu Phe Trp Asp Trp Val Gly Gly Arg
            260                 265                 270         
Tyr Ser Leu Trp Ser Ala Ile Gly Leu Ser Ile Ala Leu His Val Gly
        275                 280                 285             
Phe Asp Asn Phe Glu Gln Leu Leu Ser Gly Ala His Trp Met Asp Gln
    290                 295                 300                 
His Phe Arg Thr Thr Pro Leu Glu Lys Asn Ala Pro Val Leu Leu Ala
305                 310                 315                 320 
Leu Leu Gly Ile Trp Tyr Ile Asn Cys Phe Gly Cys Glu Thr His Ala
                325                 330                 335     
Met Leu Pro Tyr Asp Gln Tyr Leu His Arg Phe Ala Ala Tyr Phe Gln
            340                 345                 350         
Gln Gly Asp Met Glu Ser Asn Gly Lys Tyr Ile Thr Lys Ser Gly Thr
        355                 360                 365             
Arg Val Asp His Gln Thr Gly Pro Ile Val Trp Gly Glu Pro Gly Thr
    370                 375                 380                 
Asn Gly Gln His Ala Phe Tyr Gln Leu Ile His Gln Gly Thr Lys Met
385                 390                 395                 400 
Ile Pro Cys Asp Phe Leu Ile Pro Val Gln Thr Gln His Pro Ile Arg
                405                 410                 415     
Lys Gly Leu His His Lys Ile Leu Leu Ala Asn Phe Leu Ala Gln Thr
            420                 425                 430         
Glu Ala Leu Met Arg Gly Lys Ser Thr Glu Glu Ala Arg Lys Glu Leu
        435                 440                 445             
Gln Ala Ala Gly Lys Ser Pro Glu Asp Leu Glu Arg Leu Leu Pro His
    450                 455                 460                 
Lys Val Phe Glu Gly Asn Arg Pro Thr Asn Ser Ile Val Phe Thr Lys
465                 470                 475                 480 
Leu Thr Pro Phe Met Leu Gly Ala Leu Val Ala Met Tyr Glu His Lys
                485                 490                 495     
Ile Phe Val Gln Gly Ile Ile Trp Asp Ile Asn Ser Phe Asp Gln Trp
            500                 505                 510         
Gly Val Glu Leu Gly Lys Gln Leu Ala Lys Lys Ile Glu Pro Glu Leu
        515                 520                 525             
Asp Gly Ser Ala Gln Val Thr Ser His Asp Ala Ser Thr Asn Gly Leu
    530                 535                 540                 
Ile Asn Phe Ile Lys Gln Gln Arg Glu Ala Arg Val Gln
545                 550                 555         


<210> 1892
<211> 319
<212> PRT
<213> Homo sapiens

<400> 1892
Lys Ala Ser Leu Ala Ala Asp Ile Pro Arg Leu Gly Tyr Ser Ser Ser
 1               5                  10                  15      
Ser His His Lys Tyr Ile Pro Arg Arg Ala Val Leu Tyr Val Pro Gly
            20                  25                  30          
Asn Asp Glu Lys Lys Ile Lys Lys Ile Pro Ser Leu Asn Val Asp Cys
        35                  40                  45              
Ala Val Leu Asp Cys Glu Asp Gly Val Ala Ala Asn Lys Lys Asn Glu
    50                  55                  60                  
Ala Arg Leu Arg Ile Val Lys Thr Leu Glu Asp Ile Asp Leu Gly Pro
65                  70                  75                  80  
Thr Glu Lys Cys Val Arg Val Asn Ser Val Ser Ser Gly Leu Ala Glu
                85                  90                  95      
Glu Asp Leu Glu Thr Leu Leu Gln Ser Arg Val Leu Pro Ser Ser Leu
            100                 105                 110         
Met Leu Pro Lys Val Glu Ser Pro Glu Glu Ile Gln Trp Phe Ala Asp
        115                 120                 125             
Lys Phe Ser Phe His Leu Lys Gly Arg Lys Leu Glu Gln Pro Met Asn
    130                 135                 140                 
Leu Ile Pro Phe Val Glu Thr Ala Met Gly Leu Leu Asn Phe Lys Ala
145                 150                 155                 160 
Val Cys Glu Glu Thr Leu Lys Val Gly Pro Gln Val Gly Leu Phe Leu
                165                 170                 175     
Asp Ala Val Val Phe Gly Gly Glu Asp Phe Arg Ala Ser Ile Gly Ala
            180                 185                 190         
Thr Ser Ser Lys Glu Thr Leu Asp Ile Leu Tyr Ala Arg Gln Lys Ile
        195                 200                 205             
Val Val Ile Ala Lys Ala Phe Gly Leu Gln Ala Ile Asp Leu Val Tyr
    210                 215                 220                 
Ile Asp Phe Arg Asp Gly Ala Gly Leu Leu Arg Gln Ser Arg Glu Gly
225                 230                 235                 240 
Ala Ala Met Gly Phe Thr Gly Lys Gln Val Ile His Pro Asn Gln Ile
                245                 250                 255     
Ala Val Val Gln Glu Gln Phe Ser Pro Ser Pro Glu Lys Ile Lys Trp
            260                 265                 270         
Ala Glu Glu Leu Ile Ala Ala Phe Lys Glu His Gln Gln Leu Gly Lys
        275                 280                 285             
Gly Ala Phe Thr Phe Gln Gly Ser Met Ile Asp Met Pro Leu Leu Lys
    290                 295                 300                 
Gln Ala Gln Asn Thr Val Thr Leu Ala Thr Ser Ile Lys Glu Lys
305                 310                 315                 


<210> 1893
<211> 956
<212> PRT
<213> Homo sapiens

<400> 1893
Met Glu Lys Met Leu Ala Gly Cys Phe Leu Leu Ile Leu Gly Gln Ile
 1               5                  10                  15      
Val Leu Leu Pro Ala Glu Ala Arg Glu Arg Ser Arg Gly Arg Ser Ile
            20                  25                  30          
Ser Arg Gly Arg His Ala Arg Thr His Pro Gln Thr Ala Leu Leu Glu
        35                  40                  45              
Ser Ser Cys Glu Asn Lys Arg Ala Asp Leu Val Phe Ile Ile Asp Ser
    50                  55                  60                  
Ser Arg Ser Val Asn Thr His Asp Tyr Ala Lys Val Lys Glu Phe Ile
65                  70                  75                  80  
Val Asp Ile Leu Gln Phe Leu Asp Ile Gly Pro Asp Val Thr Arg Val
                85                  90                  95      
Gly Leu Leu Gln Tyr Gly Ser Thr Val Lys Asn Glu Phe Ser Leu Lys
            100                 105                 110         
Thr Phe Lys Arg Lys Ser Glu Val Glu Arg Ala Val Lys Arg Met Arg
        115                 120                 125             
His Leu Ser Thr Gly Thr Met Thr Gly Leu Ala Ile Gln Tyr Ala Leu
    130                 135                 140                 
Asn Ile Ala Phe Ser Glu Ala Glu Gly Ala Arg Pro Leu Arg Glu Asn
145                 150                 155                 160 
Val Pro Arg Val Ile Met Ile Val Thr Asp Gly Arg Pro Gln Asp Ser
                165                 170                 175     
Val Ala Glu Val Ala Ala Lys Ala Arg Asp Thr Gly Ile Leu Ile Phe
            180                 185                 190         
Ala Ile Gly Val Gly Gln Val Asp Phe Asn Thr Leu Lys Ser Ile Gly
        195                 200                 205             
Ser Glu Pro His Glu Asp His Val Phe Leu Val Ala Asn Phe Ser Gln
    210                 215                 220                 
Ile Glu Thr Leu Thr Ser Val Phe Gln Lys Lys Leu Cys Thr Ala His
225                 230                 235                 240 
Met Cys Ser Thr Leu Glu His Asn Cys Ala His Phe Cys Ile Asn Ile
                245                 250                 255     
Pro Gly Ser Tyr Val Cys Arg Cys Lys Gln Gly Tyr Ile Leu Asn Ser
            260                 265                 270         
Asp Gln Thr Thr Cys Arg Ile Gln Asp Leu Cys Ala Met Glu Asp His
        275                 280                 285             
Asn Cys Glu Gln Leu Cys Val Asn Val Pro Gly Ser Phe Val Cys Gln
    290                 295                 300                 
Cys Tyr Ser Gly Tyr Ala Leu Ala Glu Asp Gly Lys Arg Cys Val Ala
305                 310                 315                 320 
Val Asp Tyr Cys Ala Ser Glu Asn His Gly Cys Glu His Glu Cys Val
                325                 330                 335     
Asn Ala Asp Gly Ser Tyr Leu Cys Gln Cys His Glu Gly Phe Ala Leu
            340                 345                 350         
Asn Pro Asp Lys Lys Thr Cys Thr Lys Ile Asp Tyr Cys Ala Ser Ser
        355                 360                 365             
Asn His Gly Cys Gln His Glu Cys Val Asn Thr Asp Asp Ser Tyr Ser
    370                 375                 380                 
Cys His Cys Leu Lys Gly Phe Thr Leu Asn Pro Asp Lys Lys Thr Cys
385                 390                 395                 400 
Arg Arg Ile Asn Tyr Cys Ala Leu Asn Lys Pro Gly Cys Glu His Glu
                405                 410                 415     
Cys Val Asn Met Glu Glu Ser Tyr Tyr Cys Arg Cys His Arg Gly Tyr
            420                 425                 430         
Thr Leu Asp Pro Asn Gly Lys Thr Cys Ser Arg Val Asp His Cys Ala
        435                 440                 445             
Gln Gln Asp His Gly Cys Glu Gln Leu Cys Leu Asn Thr Glu Asp Ser
    450                 455                 460                 
Phe Val Cys Gln Cys Ser Glu Gly Phe Leu Ile Asn Glu Asp Leu Lys
465                 470                 475                 480 
Thr Cys Ser Arg Val Asp Tyr Cys Leu Leu Ser Asp His Gly Cys Glu
                485                 490                 495     
Tyr Ser Cys Val Asn Met Asp Arg Ser Phe Ala Cys Gln Cys Pro Glu
            500                 505                 510         
Gly His Val Leu Arg Ser Asp Gly Lys Thr Cys Ala Lys Leu Asp Ser
        515                 520                 525             
Cys Ala Leu Gly Asp His Gly Cys Glu His Ser Cys Val Ser Ser Glu
    530                 535                 540                 
Asp Ser Phe Val Cys Gln Cys Phe Glu Gly Tyr Ile Leu Arg Glu Asp
545                 550                 555                 560 
Gly Lys Thr Cys Arg Arg Lys Asp Val Cys Gln Ala Ile Asp His Gly
                565                 570                 575     
Cys Glu His Ile Cys Val Asn Ser Asp Asp Ser Tyr Thr Cys Glu Cys
            580                 585                 590         
Leu Val Gly Phe Arg Leu Ala Glu Asp Gly Lys Arg Cys Arg Arg Lys
        595                 600                 605             
Asp Val Cys Lys Ser Thr His His Gly Cys Glu His Ile Cys Val Asn
    610                 615                 620                 
Asn Gly Asn Ser Tyr Ile Cys Lys Cys Ser Glu Gly Phe Val Leu Ala
625                 630                 635                 640 
Glu Asp Gly Arg Arg Cys Lys Lys Cys Thr Glu Gly Pro Ile Asp Leu
                645                 650                 655     
Val Phe Val Ile Asp Gly Ser Lys Ser Leu Gly Glu Glu Asn Phe Glu
            660                 665                 670         
Val Val Lys Gln Phe Val Thr Gly Ile Ile Asp Ser Leu Thr Ile Ser
        675                 680                 685             
Pro Lys Ala Ala Arg Val Gly Leu Leu Gln Tyr Ser Thr Gln Val His
    690                 695                 700                 
Thr Glu Phe Thr Leu Arg Asn Phe Asn Ser Ala Lys Asp Met Lys Lys
705                 710                 715                 720 
Ala Val Ala His Met Lys Tyr Met Gly Lys Gly Ser Met Thr Gly Leu
                725                 730                 735     
Ala Leu Lys His Met Phe Glu Arg Ser Phe Thr Gln Gly Glu Gly Ala
            740                 745                 750         
Arg Pro Phe Ser Thr Arg Val Pro Arg Ala Ala Ile Val Phe Thr Asp
        755                 760                 765             
Gly Arg Ala Gln Asp Asp Val Ser Glu Trp Ala Ser Lys Ala Lys Ala
    770                 775                 780                 
Asn Gly Ile Thr Met Tyr Ala Val Gly Val Gly Lys Ala Ile Glu Glu
785                 790                 795                 800 
Glu Leu Gln Glu Ile Ala Ser Glu Pro Thr Asn Lys His Leu Phe Tyr
                805                 810                 815     
Ala Glu Asp Phe Ser Thr Met Asp Glu Ile Ser Glu Lys Leu Lys Lys
            820                 825                 830         
Gly Ile Cys Glu Ala Leu Glu Asp Ser Asp Gly Arg Gln Asp Ser Pro
        835                 840                 845             
Ala Gly Glu Leu Pro Lys Thr Val Gln Gln Pro Thr Glu Ser Glu Pro
    850                 855                 860                 
Val Thr Ile Asn Ile Gln Asp Leu Leu Ser Cys Ser Asn Phe Ala Val
865                 870                 875                 880 
Gln His Arg Tyr Leu Phe Glu Glu Asp Asn Leu Leu Arg Ser Thr Gln
                885                 890                 895     
Lys Leu Ser His Ser Thr Lys Pro Ser Gly Ser Pro Leu Glu Glu Lys
            900                 905                 910         
His Asp Gln Cys Lys Cys Glu Asn Leu Ile Met Phe Gln Asn Leu Ala
        915                 920                 925             
Asn Glu Glu Val Arg Lys Leu Thr Gln Arg Leu Glu Glu Met Thr Gln
    930                 935                 940                 
Arg Met Glu Ala Leu Glu Asn Arg Leu Arg Tyr Arg
945                 950                 955     


<210> 1894
<211> 1455
<212> PRT
<213> Homo sapiens

<400> 1894
Met Gly Gly Ala Cys Ser Ser Phe Thr Thr Ser Ser Ser Pro Thr Ile
 1               5                  10                  15      
Tyr Ser Thr Ser Val Thr Asp Ser Lys Ala Met Gln Val Glu Ser Cys
            20                  25                  30          
Ser Ser Ala Val Gly Val Ser Asn Arg Gly Val Ser Glu Lys Gln Leu
        35                  40                  45              
Thr Ser Asn Thr Val Gln Gln His Pro Ser Thr Pro Lys Arg His Thr
    50                  55                  60                  
Val Leu Tyr Ile Ser Pro Pro Pro Glu Asp Leu Leu Asp Asn Ser Arg
65                  70                  75                  80  
Met Ser Cys Gln Asp Glu Gly Cys Gly Leu Glu Ser Glu Gln Ser Cys
                85                  90                  95      
Ser Met Trp Met Glu Asp Ser Pro Ser Asn Phe Ser Asn Met Ser Thr
            100                 105                 110         
Ser Ser Tyr Asn Asp Asn Thr Glu Val Pro Arg Lys Ser Arg Lys Arg
        115                 120                 125             
Asn Pro Lys Gln Arg Pro Gly Val Lys Arg Arg Asp Cys Glu Glu Ser
    130                 135                 140                 
Asn Met Asp Ile Phe Asp Ala Asp Ser Ala Lys Ala Pro His Tyr Val
145                 150                 155                 160 
Leu Ser Gln Leu Thr Thr Asp Asn Lys Gly Asn Ser Lys Ala Gly Asn
                165                 170                 175     
Gly Thr Leu Glu Asn Gln Lys Gly Thr Gly Val Lys Lys Ser Pro Met
            180                 185                 190         
Leu Cys Gly Gln Tyr Pro Val Lys Ser Glu Gly Lys Glu Leu Lys Ile
        195                 200                 205             
Val Val Gln Pro Glu Thr Gln His Arg Ala Arg Tyr Leu Thr Glu Gly
    210                 215                 220                 
Ser Arg Gly Ser Val Lys Asp Arg Thr Gln Gln Gly Phe Pro Thr Val
225                 230                 235                 240 
Lys Leu Glu Gly His Asn Glu Pro Val Val Leu Gln Val Phe Val Gly
                245                 250                 255     
Asn Asp Ser Gly Arg Val Lys Pro His Gly Phe Tyr Gln Ala Cys Arg
            260                 265                 270         
Val Thr Gly Arg Asn Thr Thr Pro Cys Lys Glu Val Asp Ile Glu Gly
        275                 280                 285             
Thr Thr Val Ile Glu Val Gly Leu Asp Pro Ser Asn Asn Met Thr Leu
    290                 295                 300                 
Ala Val Asp Cys Val Gly Ile Leu Lys Leu Arg Asn Ala Asp Val Glu
305                 310                 315                 320 
Ala Arg Ile Gly Ile Ala Gly Ser Lys Lys Lys Ser Thr Arg Ala Arg
                325                 330                 335     
Leu Val Phe Arg Val Asn Ile Met Arg Lys Asp Gly Ser Thr Leu Thr
            340                 345                 350         
Leu Gln Thr Pro Ser Ser Pro Ile Leu Cys Thr Gln Pro Ala Gly Val
        355                 360                 365             
Pro Glu Ile Leu Lys Lys Ser Leu His Ser Cys Ser Val Lys Gly Glu
    370                 375                 380                 
Glu Glu Val Phe Leu Ile Gly Lys Asn Phe Leu Lys Gly Thr Lys Val
385                 390                 395                 400 
Ile Phe Gln Glu Asn Val Ser Asp Glu Asn Ser Trp Lys Ser Glu Ala
                405                 410                 415     
Glu Ile Asp Met Glu Leu Phe His Gln Asn His Leu Ile Val Lys Val
            420                 425                 430         
Pro Pro Tyr His Asp Gln His Ile Thr Leu Pro Val Ser Val Gly Ile
        435                 440                 445             
Tyr Val Val Thr Asn Ala Gly Arg Ser His Asp Val Gln Pro Phe Thr
    450                 455                 460                 
Tyr Thr Pro Asp Pro Ala Ala Ala Gly Ala Leu Asn Val Asn Val Lys
465                 470                 475                 480 
Lys Glu Ile Ser Ser Pro Ala Arg Pro Cys Ser Phe Glu Glu Ala Met
                485                 490                 495     
Lys Ala Met Lys Thr Thr Gly Cys Asn Leu Asp Lys Val Asn Ile Ile
            500                 505                 510         
Pro Asn Ala Leu Met Thr Pro Leu Ile Pro Ser Ser Met Ile Lys Ser
        515                 520                 525             
Glu Asp Val Thr Pro Met Glu Val Thr Ala Glu Lys Arg Ser Ser Thr
    530                 535                 540                 
Ile Phe Lys Thr Thr Lys Ser Val Gly Ser Thr Gln Gln Thr Leu Glu
545                 550                 555                 560 
Asn Ile Ser Asn Ile Ala Gly Asn Gly Ser Phe Ser Ser Pro Ser Ser
                565                 570                 575     
Ser His Leu Pro Ser Glu Asn Glu Lys Gln Gln Gln Ile His Ala Lys
            580                 585                 590         
Ala Tyr Asn Pro Glu Thr Leu Thr Thr Ile Gln Thr Gln Asp Ile Ser
        595                 600                 605             
Gln Pro Gly Thr Phe Pro Ala Val Ser Ala Ser Ser Gln Leu Pro Asn
    610                 615                 620                 
Ser Asp Ala Leu Leu Gln Gln Ala Thr Gln Phe Gln Thr Arg Glu Thr
625                 630                 635                 640 
Gln Ser Arg Glu Ile Leu Gln Ser Asp Gly Thr Val Val Asn Leu Ser
                645                 650                 655     
Gln Leu Thr Glu Ala Ser Gln Gln Gln Gln Gln Ser Pro Leu Gln Glu
            660                 665                 670         
Gln Ala Gln Thr Leu Gln Gln Gln Ile Ser Ser Asn Ile Phe Pro Ser
        675                 680                 685             
Pro Asn Ser Val Ser Gln Leu Gln Asn Thr Ile Gln Gln Leu Gln Ala
    690                 695                 700                 
Gly Ser Phe Thr Gly Ser Thr Ala Ser Gly Ser Ser Gly Ser Val Asp
705                 710                 715                 720 
Leu Val Gln Gln Val Leu Glu Ala Gln Gln Gln Leu Ser Ser Val Leu
                725                 730                 735     
Phe Ser Ala Pro Asp Gly Asn Glu Asn Val Gln Glu Gln Leu Ser Ala
            740                 745                 750         
Asp Ile Phe Gln Gln Val Ser Gln Ile Gln Ser Gly Val Ser Pro Gly
        755                 760                 765             
Met Phe Ser Ser Thr Glu Pro Thr Val His Thr Arg Pro Asp Asn Leu
    770                 775                 780                 
Leu Pro Gly Arg Ala Glu Ser Val His Pro Gln Ser Glu Asn Thr Leu
785                 790                 795                 800 
Ser Asn Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Val Met Glu Ser
                805                 810                 815     
Ser Ala Ala Met Val Met Glu Met Gln Gln Ser Ile Cys Gln Ala Ala
            820                 825                 830         
Ala Gln Ile Gln Ser Glu Leu Phe Pro Ser Thr Ala Ser Ala Asn Gly
        835                 840                 845             
Asn Leu Gln Gln Ser Pro Val Tyr Gln Gln Thr Ser His Met Met Ser
    850                 855                 860                 
Ala Leu Ser Thr Asn Glu Asp Met Gln Met Gln Cys Glu Leu Phe Ser
865                 870                 875                 880 
Ser Pro Pro Ala Val Ser Gly Asn Glu Thr Ser Thr Thr Thr Thr Gln
                885                 890                 895     
Gln Val Ala Thr Pro Gly Thr Thr Met Phe Gln Thr Ser Ser Ser Gly
            900                 905                 910         
Asp Gly Glu Glu Thr Gly Thr Gln Ala Lys Gln Ile Gln Asn Ser Val
        915                 920                 925             
Phe Gln Thr Met Val Gln Met Gln His Ser Gly Asp Asn Gln Pro Gln
    930                 935                 940                 
Val Asn Leu Phe Ser Ser Thr Lys Ser Met Met Ser Val Gln Asn Ser
945                 950                 955                 960 
Gly Thr Gln Gln Gln Gly Asn Gly Leu Phe Gln Gln Gly Asn Glu Met
                965                 970                 975     
Met Ser Leu Gln Ser Gly Asn Phe Leu Gln Gln Ser Ser His Ser Gln
            980                 985                 990         
Ala Gln Leu Phe His Pro Gln Asn Pro Ile Ala Asp Ala Gln Asn Leu
        995                 1000                1005            
Ser Gln Glu Thr Gln Gly Ser Leu Phe His Ser Pro Asn Pro Ile Val
    1010                1015                1020                
His Ser Gln Thr Ser Thr Thr Ser Ser Glu Gln Met Gln Pro Pro Met
1025                1030                1035                1040
Phe His Ser Gln Ser Thr Ile Ala Val Leu Gln Gly Ser Ser Val Pro
                1045                1050                1055    
Gln Asp Gln Gln Ser Thr Asn Ile Phe Leu Ser Gln Ser Pro Met Asn
            1060                1065                1070        
Asn Leu Gln Thr Asn Thr Val Ala Gln Glu Ala Phe Phe Ala Ala Pro
        1075                1080                1085            
Asn Ser Ile Ser Pro Leu Gln Ser Thr Ser Asn Ser Glu Gln Gln Ala
    1090                1095                1100                
Ala Phe Gln Gln Gln Ala Pro Ile Ser His Ile Gln Thr Pro Met Leu
1105                1110                1115                1120
Ser Gln Glu Gln Ala Gln Pro Pro Gln Gln Gly Leu Phe Gln Pro Gln
                1125                1130                1135    
Val Ala Leu Gly Ser Leu Pro Pro Asn Pro Met Pro Gln Ser Gln Gln
            1140                1145                1150        
Gly Thr Met Phe Gln Ser Gln His Ser Ile Val Ala Met Gln Ser Asn
        1155                1160                1165            
Ser Pro Ser Gln Glu Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
    1170                1175                1180                
Gln Gln Gln Gln Gln Gln Ser Ile Leu Phe Ser Asn Gln Asn Thr Met
1185                1190                1195                1200
Ala Thr Met Ala Ser Pro Lys Gln Pro Pro Pro Asn Met Ile Phe Asn
                1205                1210                1215    
Pro Asn Gln Asn Pro Met Ala Asn Gln Glu Gln Gln Asn Gln Ser Ile
            1220                1225                1230        
Phe His Gln Gln Ser Asn Met Ala Pro Met Asn Gln Glu Gln Gln Pro
        1235                1240                1245            
Met Gln Phe Gln Ser Gln Ser Thr Val Ser Ser Leu Gln Asn Pro Gly
    1250                1255                1260                
Pro Thr Gln Ser Glu Ser Ser Gln Thr Pro Leu Phe His Ser Ser Pro
1265                1270                1275                1280
Gln Ile Gln Leu Val Gln Gly Ser Pro Ser Ser Gln Glu Gln Gln Val
                1285                1290                1295    
Thr Leu Phe Leu Ser Pro Ala Ser Met Ser Ala Leu Gln Thr Ser Ile
            1300                1305                1310        
Asn Gln Gln Asp Met Gln Gln Ser Pro Leu Tyr Ser Pro Gln Asn Asn
        1315                1320                1325            
Met Pro Gly Ile Gln Gly Ala Thr Ser Ser Pro Gln Pro Gln Ala Thr
    1330                1335                1340                
Leu Phe His Asn Thr Ala Gly Gly Thr Met Asn Gln Leu Gln Asn Ser
1345                1350                1355                1360
Pro Gly Ser Ser Gln Gln Thr Ser Gly Met Phe Leu Phe Gly Ile Gln
                1365                1370                1375    
Asn Asn Cys Ser Gln Leu Leu Thr Ser Gly Pro Ala Thr Leu Pro Asp
            1380                1385                1390        
Gln Leu Met Ala Ile Ser Gln Pro Gly Gln Pro Gln Asn Glu Gly Gln
        1395                1400                1405            
Pro Pro Val Thr Thr Leu Leu Ser Gln Gln Met Pro Glu Asn Ser Pro
    1410                1415                1420                
Leu Ala Ser Ser Ile Asn Thr Asn Gln Asn Ile Glu Lys Ile Asp Leu
1425                1430                1435                1440
Leu Val Ser Leu Gln Asn Gln Gly Asn Asn Leu Thr Gly Ser Phe
                1445                1450                1455


<210> 1895
<211> 5636
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 3003, 3041, 3367
<223> Xaa = Any Amino Acid

<400> 1895
Met Ile Ser Trp Glu Val Val His Thr Val Phe Leu Phe Ala Leu Leu
 1               5                  10                  15      
Tyr Ser Ser Leu Ala Gln Asp Ala Ser Pro Gln Ser Glu Ile Arg Ala
            20                  25                  30          
Glu Glu Phe Pro Glu Gly Ala Ser Thr Leu Ala Phe Val Phe Asp Val
        35                  40                  45              
Thr Gly Ser Met Tyr Asp Asp Leu Val Gln Val Ile Glu Gly Ala Ser
    50                  55                  60                  
Lys Ile Leu Glu Thr Ser Leu Lys Arg Pro Lys Arg Pro Leu Phe Asn
65                  70                  75                  80  
Phe Ala Leu Val Pro Phe His Asp Pro Glu Ile Gly Pro Val Thr Ile
                85                  90                  95      
Thr Thr Asp Pro Lys Lys Phe Gln Tyr Glu Leu Arg Glu Leu Tyr Val
            100                 105                 110         
Gln Gly Gly Gly Asp Cys Pro Glu Met Ser Ile Gly Ala Ile Lys Ile
        115                 120                 125             
Ala Leu Glu Ile Ser Leu Pro Gly Ser Phe Ile Tyr Val Phe Thr Asp
    130                 135                 140                 
Ala Arg Ser Lys Asp Tyr Arg Leu Thr His Glu Val Leu Gln Leu Ile
145                 150                 155                 160 
Gln Gln Lys Gln Ser Gln Val Val Phe Val Leu Thr Gly Asp Cys Asp
                165                 170                 175     
Asp Arg Thr His Ile Gly Tyr Lys Val Tyr Glu Glu Ile Ala Ser Thr
            180                 185                 190         
Ser Ser Gly Gln Val Phe His Leu Asp Lys Lys Gln Val Asn Glu Val
        195                 200                 205             
Leu Lys Trp Val Glu Glu Ala Val Gln Ala Ser Lys Val His Leu Leu
    210                 215                 220                 
Ser Thr Asp His Leu Glu Gln Ala Val Asn Thr Trp Arg Ile Pro Phe
225                 230                 235                 240 
Asp Pro Ser Leu Lys Glu Val Thr Val Ser Leu Ser Gly Pro Ser Pro
                245                 250                 255     
Met Ile Glu Ile Arg Asn Pro Leu Gly Lys Leu Ile Lys Lys Gly Phe
            260                 265                 270         
Gly Leu His Glu Leu Leu Asn Ile His Asn Ser Ala Lys Val Val Asn
        275                 280                 285             
Val Lys Glu Pro Glu Ala Gly Met Trp Thr Val Lys Thr Ser Ser Ser
    290                 295                 300                 
Gly Arg His Ser Val Arg Ile Thr Gly Leu Ser Thr Ile Asp Phe Arg
305                 310                 315                 320 
Ala Gly Phe Ser Arg Lys Pro Thr Leu Asp Phe Lys Lys Thr Val Ser
                325                 330                 335     
Arg Pro Val Gln Gly Ile Pro Thr Tyr Val Leu Leu Asn Thr Ser Gly
            340                 345                 350         
Ile Ser Thr Pro Ala Arg Ile Asp Leu Leu Glu Leu Leu Ser Ile Ser
        355                 360                 365             
Gly Ser Ser Leu Lys Thr Ile Pro Val Lys Tyr Tyr Pro His Arg Lys
    370                 375                 380                 
Pro Tyr Gly Ile Trp Asn Ile Ser Asp Phe Val Pro Pro Asn Glu Ala
385                 390                 395                 400 
Phe Phe Leu Lys Val Thr Gly Tyr Asp Lys Asp Asp Tyr Leu Phe Gln
                405                 410                 415     
Arg Val Ser Ser Val Ser Phe Ser Ser Ile Val Pro Asp Ala Pro Lys
            420                 425                 430         
Val Thr Met Pro Glu Lys Thr Pro Gly Tyr Tyr Leu Gln Pro Gly Gln
        435                 440                 445             
Ile Pro Cys Ser Val Asp Ser Leu Leu Pro Phe Thr Leu Ser Phe Val
    450                 455                 460                 
Arg Asn Gly Val Thr Leu Gly Val Asp Gln Tyr Leu Lys Glu Ser Ala
465                 470                 475                 480 
Ser Val Ser Leu Asp Ile Ala Lys Val Thr Leu Ser Asp Glu Gly Phe
                485                 490                 495     
Tyr Glu Cys Ile Ala Val Ser Ser Ala Gly Thr Gly Arg Ala Gln Thr
            500                 505                 510         
Phe Phe Asp Val Ser Glu Pro Pro Pro Val Ile Gln Val Pro Asn Asn
        515                 520                 525             
Val Thr Val Thr Pro Gly Glu Arg Ala Val Leu Thr Cys Leu Ile Ile
    530                 535                 540                 
Ser Ala Val Asp Tyr Asn Leu Thr Trp Gln Arg Asn Asp Arg Asp Val
545                 550                 555                 560 
Arg Leu Ala Glu Pro Ala Arg Ile Arg Thr Leu Ala Asn Leu Ser Leu
                565                 570                 575     
Glu Leu Lys Ser Val Lys Phe Asn Asp Ala Gly Glu Tyr His Cys Met
            580                 585                 590         
Val Ser Ser Glu Gly Gly Ser Ser Ala Ala Ser Val Phe Leu Thr Val
        595                 600                 605             
Gln Glu Pro Pro Lys Val Thr Val Met Pro Lys Asn Gln Ser Phe Thr
    610                 615                 620                 
Gly Gly Ser Glu Val Ser Ile Met Cys Ser Ala Thr Gly Tyr Pro Lys
625                 630                 635                 640 
Pro Lys Ile Ala Trp Thr Val Asn Asp Met Phe Ile Val Gly Ser His
                645                 650                 655     
Arg Tyr Arg Met Thr Ser Asp Gly Thr Leu Phe Ile Lys Asn Ala Ala
            660                 665                 670         
Pro Lys Asp Ala Gly Ile Tyr Gly Cys Leu Ala Ser Asn Ser Ala Gly
        675                 680                 685             
Thr Asp Lys Gln Asn Ser Thr Leu Arg Tyr Ile Glu Ala Pro Lys Leu
    690                 695                 700                 
Met Val Val Gln Ser Glu Leu Leu Val Ala Leu Gly Asp Ile Thr Val
705                 710                 715                 720 
Met Glu Cys Lys Thr Ser Gly Ile Pro Pro Pro Gln Val Lys Trp Phe
                725                 730                 735     
Lys Gly Asp Leu Glu Leu Arg Pro Ser Thr Phe Leu Ile Ile Asp Pro
            740                 745                 750         
Leu Leu Gly Leu Leu Lys Ile Gln Glu Thr Gln Asp Leu Asp Ala Gly
        755                 760                 765             
Asp Tyr Thr Cys Val Ala Ile Asn Glu Ala Gly Arg Ala Thr Gly Lys
    770                 775                 780                 
Ile Thr Leu Asp Val Gly Ser Pro Pro Val Phe Ile Gln Glu Pro Ala
785                 790                 795                 800 
Asp Val Ser Met Glu Ile Gly Ser Asn Val Thr Leu Pro Cys Tyr Val
                805                 810                 815     
Gln Gly Tyr Pro Glu Pro Thr Ile Lys Trp Arg Arg Leu Asp Asn Met
            820                 825                 830         
Pro Ile Phe Ser Arg Pro Phe Ser Val Ser Ser Ile Ser Gln Leu Arg
        835                 840                 845             
Thr Gly Ala Leu Phe Ile Leu Asn Leu Trp Ala Ser Asp Lys Gly Thr
    850                 855                 860                 
Tyr Ile Cys Glu Ala Glu Asn Gln Phe Gly Lys Ile Gln Ser Glu Thr
865                 870                 875                 880 
Thr Val Thr Val Thr Gly Leu Val Ala Pro Leu Ile Gly Ile Ser Pro
                885                 890                 895     
Ser Val Ala Asn Val Ile Glu Gly Gln Gln Leu Thr Leu Pro Cys Thr
            900                 905                 910         
Leu Leu Ala Gly Asn Pro Ile Pro Glu Arg Arg Trp Ile Lys Asn Ser
        915                 920                 925             
Ala Met Leu Leu Gln Asn Pro Tyr Ile Thr Val Arg Ser Asp Gly Ser
    930                 935                 940                 
Leu His Ile Glu Arg Val Gln Leu Gln Asp Gly Gly Glu Tyr Thr Cys
945                 950                 955                 960 
Val Ala Ser Asn Val Ala Gly Thr Asn Asn Lys Thr Thr Ser Val Val
                965                 970                 975     
Val His Val Leu Pro Thr Ile Gln His Gly Gln Gln Ile Leu Ser Thr
            980                 985                 990         
Ile Glu Gly Ile Pro Val Thr Leu Pro Cys Lys Ala Ser Gly Asn Pro
        995                 1000                1005            
Lys Pro Ser Val Ile Trp Ser Lys Lys Gly Glu Leu Ile Ser Thr Ser
    1010                1015                1020                
Ser Ala Lys Phe Ser Ala Gly Ala Asp Gly Ser Leu Tyr Val Val Ser
1025                1030                1035                1040
Pro Glu Gly Glu Glu Ser Gly Glu Tyr Val Cys Thr Ala Thr Asn Thr
                1045                1050                1055    
Ala Gly Tyr Ala Lys Arg Lys Val Gln Leu Thr Val Tyr Val Arg Pro
            1060                1065                1070        
Arg Val Phe Gly Asp Leu Arg Gly Leu Ser Gln Asp Lys Pro Val Glu
        1075                1080                1085            
Ile Ser Val Leu Ala Gly Glu Glu Val Thr Leu Pro Cys Glu Val Lys
    1090                1095                1100                
Ser Leu Pro Pro Pro Ile Ile Thr Trp Ala Lys Glu Thr Gln Leu Ile
1105                1110                1115                1120
Ser Pro Phe Ser Pro Arg His Thr Phe Leu Pro Ser Gly Ser Met Lys
                1125                1130                1135    
Ile Thr Glu Thr Arg Thr Ser Asp Ser Gly Met Tyr Leu Cys Val Ala
            1140                1145                1150        
Thr Asn Ile Ala Gly Asn Val Thr Gln Ala Val Lys Leu Asn Val His
        1155                1160                1165            
Val Pro Pro Lys Ile Gln Arg Gly Pro Lys His Leu Lys Val Gln Val
    1170                1175                1180                
Gly Gln Arg Val Asp Ile Pro Cys Asn Ala Gln Gly Thr Pro Leu Pro
1185                1190                1195                1200
Val Ile Thr Trp Ser Lys Gly Gly Ser Thr Met Leu Val Asp Gly Glu
                1205                1210                1215    
His His Val Ser Asn Pro Asp Gly Thr Leu Ser Ile Asp Gln Ala Thr
            1220                1225                1230        
Pro Ser Asp Ala Gly Ile Tyr Thr Cys Val Ala Thr Asn Ile Ala Gly
        1235                1240                1245            
Thr Asp Glu Thr Glu Ile Thr Leu His Val Gln Glu Pro Pro Thr Val
    1250                1255                1260                
Glu Asp Leu Glu Pro Pro Tyr Asn Thr Thr Phe Gln Glu Arg Val Ala
1265                1270                1275                1280
Asn Gln Arg Ile Glu Phe Pro Cys Pro Ala Lys Gly Thr Pro Lys Pro
                1285                1290                1295    
Thr Ile Lys Trp Leu His Asn Gly Arg Glu Leu Thr Gly Arg Glu Pro
            1300                1305                1310        
Gly Ile Ser Ile Leu Glu Glu Gly Thr Leu Leu Val Ile Ala Ser Val
        1315                1320                1325            
Thr Pro Tyr Asp Asn Gly Glu Tyr Ile Cys Val Ala Val Asn Glu Ala
    1330                1335                1340                
Gly Thr Thr Glu Arg Lys Tyr Asn Leu Lys Val His Val Pro Pro Val
1345                1350                1355                1360
Ile Lys Asp Lys Glu Gln Val Ser Asn Val Ser Val Leu Leu Asn Gln
                1365                1370                1375    
Leu Thr Asn Leu Phe Cys Glu Val Glu Gly Thr Pro Ser Pro Ile Ile
            1380                1385                1390        
Met Trp Tyr Lys Asp Asn Val Gln Val Thr Glu Ser Ser Thr Ile Gln
        1395                1400                1405            
Thr Val Asn Asn Gly Lys Ile Leu Lys Leu Phe Arg Ala Thr Pro Glu
    1410                1415                1420                
Asp Ala Gly Arg Tyr Ser Cys Lys Ala Ile Asn Ile Ala Gly Thr Ser
1425                1430                1435                1440
Gln Lys Tyr Phe Asn Ile Asp Val Leu Val Pro Pro Thr Ile Ile Gly
                1445                1450                1455    
Thr Asn Phe Pro Lys Glu Val Ser Val Val Leu Asn Arg Asp Val Ala
            1460                1465                1470        
Leu Glu Cys Gln Val Lys Gly Thr Pro Phe Pro Asp Ile His Trp Phe
        1475                1480                1485            
Lys Asp Gly Lys Pro Leu Phe Leu Gly Asp Pro Asn Val Glu Leu Leu
    1490                1495                1500                
Asp Arg Gly Gln Val Leu His Leu Lys Asn Ala Arg Arg Asn Asp Lys
1505                1510                1515                1520
Gly Arg Tyr Gln Cys Thr Val Ser Asn Ala Ala Gly Lys Gln Ala Lys
                1525                1530                1535    
Asp Ile Lys Leu Thr Ile Tyr Ile Pro Pro Ser Ile Lys Gly Gly Asn
            1540                1545                1550        
Val Thr Thr Asp Ile Ser Val Leu Ile Asn Ser Leu Ile Lys Leu Glu
        1555                1560                1565            
Cys Lys Thr Arg Gly Leu Pro Met Pro Ala Ile Thr Trp Tyr Lys Asp
    1570                1575                1580                
Gly Gln Pro Ile Met Ser Ser Ser Gln Ala Leu Tyr Ile Asp Lys Gly
1585                1590                1595                1600
Gln Tyr Leu His Ile Pro Arg Ala Gln Val Ser Asp Ser Ala Thr Tyr
                1605                1610                1615    
Thr Cys His Val Ala Asn Val Ala Gly Thr Ala Glu Lys Ser Phe His
            1620                1625                1630        
Val Asp Val Tyr Val Pro Pro Met Ile Glu Gly Asn Leu Ala Thr Pro
        1635                1640                1645            
Leu Asn Lys Gln Val Val Ile Ala His Ser Leu Thr Leu Glu Cys Asn
    1650                1655                1660                
Ala Ala Gly Asn Pro Ser Pro Ile Leu Thr Trp Leu Lys Asp Gly Val
1665                1670                1675                1680
Pro Val Lys Ala Asn Asp Asn Phe Arg Ile Glu Ala Gly Gly Lys Lys
                1685                1690                1695    
Leu Glu Ile Met Ser Ala Gln Glu Ile Asp Arg Gly Gln Tyr Ile Cys
            1700                1705                1710        
Val Ala Thr Ser Val Ala Gly Glu Lys Glu Ile Lys Tyr Glu Val Asp
        1715                1720                1725            
Val Leu Val Pro Pro Ala Ile Glu Gly Gly Asp Glu Thr Ser Tyr Phe
    1730                1735                1740                
Ile Val Met Val Asn Asn Leu Leu Glu Leu Asp Cys His Val Thr Gly
1745                1750                1755                1760
Ser Pro Pro Pro Thr Ile Met Trp Leu Lys Asp Gly Gln Leu Ile Asp
                1765                1770                1775    
Glu Arg Asp Gly Phe Lys Ile Leu Leu Asn Gly Arg Lys Leu Val Ile
            1780                1785                1790        
Ala Gln Ala Gln Val Ser Asn Thr Gly Leu Tyr Arg Cys Met Ala Ala
        1795                1800                1805            
Asn Thr Ala Gly Asp His Lys Lys Glu Phe Glu Val Thr Val His Val
    1810                1815                1820                
Pro Pro Thr Ile Lys Ser Ser Gly Leu Ser Glu Arg Val Val Val Lys
1825                1830                1835                1840
Tyr Lys Pro Val Ala Leu Gln Cys Ile Ala Asn Gly Ile Pro Asn Pro
                1845                1850                1855    
Ser Ile Thr Trp Leu Lys Asp Asp Gln Pro Val Asn Thr Ala Gln Gly
            1860                1865                1870        
Asn Leu Lys Ile Gln Ser Ser Gly Arg Val Leu Gln Ile Ala Lys Thr
        1875                1880                1885            
Leu Leu Glu Asp Ala Gly Arg Tyr Thr Cys Val Ala Thr Asn Ala Ala
    1890                1895                1900                
Gly Glu Thr Gln Gln His Ile Gln Leu His Val His Glu Pro Pro Ser
1905                1910                1915                1920
Leu Glu Asp Ala Gly Lys Met Leu Asn Glu Thr Val Leu Val Ser Asn
                1925                1930                1935    
Pro Val Gln Leu Glu Cys Lys Ala Ala Gly Asn Pro Val Pro Val Ile
            1940                1945                1950        
Thr Trp Tyr Lys Asp Asn Cys Leu Leu Ser Gly Ser Thr Ser Met Thr
        1955                1960                1965            
Phe Leu Asn Arg Gly Gln Ile Ile Asp Ile Glu Ser Ala Gln Ile Ser
    1970                1975                1980                
Asp Ala Gly Ile Tyr Lys Cys Val Ala Ile Asn Ser Ala Gly Ala Thr
1985                1990                1995                2000
Glu Leu Phe Tyr Ser Leu Gln Val His Val Ala Pro Ser Ile Ser Gly
                2005                2010                2015    
Ser Asn Asn Met Val Ala Val Val Val Asn Asn Pro Val Arg Leu Glu
            2020                2025                2030        
Cys Glu Ala Arg Gly Ile Pro Ala Pro Ser Leu Thr Trp Leu Lys Asp
        2035                2040                2045            
Gly Ser Pro Val Ser Ser Phe Ser Asn Gly Leu Gln Val Leu Ser Gly
    2050                2055                2060                
Gly Arg Ile Leu Ala Leu Thr Ser Thr Gln Ile Ser Asp Thr Gly Arg
2065                2070                2075                2080
Tyr Thr Cys Val Ala Val Asn Ala Ala Gly Glu Lys Gln Arg Asp Ile
                2085                2090                2095    
Asp Leu Arg Val Tyr Val Pro Pro Asn Ile Met Gly Glu Glu Gln Asn
            2100                2105                2110        
Val Ser Val Leu Ile Ser Gln Ala Val Glu Leu Leu Cys Gln Ser Asp
        2115                2120                2125            
Ala Ile Pro Pro Pro Thr Leu Thr Trp Leu Lys Asp Gly His Pro Leu
    2130                2135                2140                
Leu Lys Lys Pro Gly Leu Ser Ile Ser Glu Asn Arg Ser Val Leu Lys
2145                2150                2155                2160
Ile Glu Asp Ala Gln Val Gln Asp Thr Gly Arg Tyr Thr Cys Glu Ala
                2165                2170                2175    
Thr Asn Val Ala Gly Lys Thr Glu Lys Lys Asn Tyr Asn Val Asn Ile
            2180                2185                2190        
Trp Val Pro Pro Asn Ile Gly Gly Ser Asp Glu Leu Thr Gln Leu Thr
        2195                2200                2205            
Val Ile Glu Gly Asn Leu Ile Ser Leu Leu Cys Glu Ser Ser Gly Ile
    2210                2215                2220                
Pro Pro Pro Asn Leu Ile Trp Lys Lys Lys Gly Ser Pro Val Leu Thr
2225                2230                2235                2240
Asp Ser Met Gly Arg Val Arg Ile Leu Ser Gly Gly Arg Gln Leu Gln
                2245                2250                2255    
Ile Ser Ile Ala Glu Lys Ser Asp Ala Ala Leu Tyr Ser Cys Val Ala
            2260                2265                2270        
Ser Asn Val Ala Gly Thr Ala Lys Lys Glu Tyr Asn Leu Gln Val Tyr
        2275                2280                2285            
Ile Arg Pro Thr Ile Thr Asn Ser Gly Ser His Pro Thr Glu Ile Ile
    2290                2295                2300                
Val Thr Arg Gly Lys Ser Ile Ser Leu Glu Cys Glu Val Gln Gly Ile
2305                2310                2315                2320
Pro Pro Pro Thr Val Thr Trp Met Lys Asp Gly His Pro Leu Ile Lys
                2325                2330                2335    
Ala Lys Gly Val Glu Ile Leu Asp Glu Gly His Ile Leu Gln Leu Lys
            2340                2345                2350        
Asn Ile His Val Ser Asp Thr Gly Arg Tyr Val Cys Val Ala Val Asn
        2355                2360                2365            
Val Ala Gly Met Thr Asp Lys Lys Tyr Asp Leu Ser Val His Ala Pro
    2370                2375                2380                
Pro Ser Ile Ile Gly Asn His Arg Ser Pro Glu Asn Ile Ser Val Val
2385                2390                2395                2400
Glu Lys Asn Ser Val Ser Leu Thr Cys Glu Ala Ser Gly Ile Pro Leu
                2405                2410                2415    
Pro Ser Thr Thr Trp Phe Lys Asp Gly Trp Pro Val Ser Leu Ser Asn
            2420                2425                2430        
Ser Val Arg Ile Leu Ser Gly Gly Arg Met Leu Arg Leu Met Gln Thr
        2435                2440                2445            
Thr Met Glu Asp Ala Gly Gln Tyr Thr Cys Val Val Arg Asn Ala Ala
    2450                2455                2460                
Gly Glu Glu Arg Lys Ile Phe Gly Leu Ser Val Leu Val Pro Pro His
2465                2470                2475                2480
Ile Val Gly Glu Asn Thr Leu Glu Asp Val Lys Val Lys Glu Lys Gln
                2485                2490                2495    
Ser Val Thr Leu Thr Cys Glu Val Thr Gly Asn Pro Val Pro Glu Ile
            2500                2505                2510        
Thr Trp His Lys Asp Gly Gln Pro Leu Gln Glu Asp Glu Ala His His
        2515                2520                2525            
Ile Ile Ser Gly Gly Arg Phe Leu Gln Ile Thr Asn Val Gln Val Pro
    2530                2535                2540                
His Thr Gly Arg Tyr Thr Cys Leu Ala Ser Ser Pro Ala Gly His Lys
2545                2550                2555                2560
Ser Arg Ser Phe Ser Leu Asn Val Phe Val Ser Pro Thr Ile Ala Gly
                2565                2570                2575    
Val Gly Ser Asp Gly Asn Pro Glu Asp Val Thr Val Ile Leu Asn Ser
            2580                2585                2590        
Pro Thr Ser Leu Val Cys Glu Ala Tyr Ser Tyr Pro Pro Ala Thr Ile
        2595                2600                2605            
Thr Trp Phe Lys Asp Gly Thr Pro Leu Glu Ser Asn Arg Asn Ile Arg
    2610                2615                2620                
Ile Leu Pro Gly Gly Arg Thr Leu Gln Ile Leu Asn Ala Gln Glu Asp
2625                2630                2635                2640
Asn Ala Gly Arg Tyr Ser Cys Val Ala Thr Asn Glu Ala Gly Glu Met
                2645                2650                2655    
Ile Lys His Tyr Glu Val Lys Val Tyr Ile Pro Pro Ile Ile Asn Lys
            2660                2665                2670        
Gly Asp Leu Trp Gly Pro Gly Leu Ser Pro Lys Glu Val Lys Ile Lys
        2675                2680                2685            
Val Asn Asn Thr Leu Thr Leu Glu Cys Glu Ala Tyr Ala Ile Pro Ser
    2690                2695                2700                
Ala Ser Leu Ser Trp Tyr Lys Asp Gly Gln Pro Leu Lys Ser Asp Asp
2705                2710                2715                2720
His Val Asn Ile Ala Ala Asn Gly His Thr Leu Gln Ile Lys Glu Ala
                2725                2730                2735    
Gln Ile Ser Asp Thr Gly Arg Tyr Thr Cys Val Ala Ser Asn Ile Ala
            2740                2745                2750        
Gly Glu Asp Glu Leu Asp Phe Asp Val Asn Ile Gln Val Pro Pro Ser
        2755                2760                2765            
Phe Gln Lys Leu Trp Glu Ile Gly Asn Met Leu Asp Thr Gly Arg Asn
    2770                2775                2780                
Gly Glu Ala Lys Asp Val Ile Ile Asn Asn Pro Ile Ser Leu Tyr Cys
2785                2790                2795                2800
Glu Thr Asn Ala Ala Pro Pro Pro Thr Leu Thr Trp Tyr Lys Asp Gly
                2805                2810                2815    
His Pro Leu Thr Ser Ser Asp Lys Val Leu Ile Leu Pro Gly Gly Arg
            2820                2825                2830        
Val Leu Gln Ile Pro Arg Ala Lys Val Glu Asp Ala Gly Arg Tyr Thr
        2835                2840                2845            
Cys Val Ala Val Asn Glu Ala Gly Glu Asp Ser Leu Gln Tyr Asp Val
    2850                2855                2860                
Arg Val Leu Val Pro Pro Ile Ile Glu Gly Ala Asn Ser Asp Leu Pro
2865                2870                2875                2880
Glu Glu Val Thr Val Leu Val Asn Lys Ser Ala Leu Ile Glu Cys Leu
                2885                2890                2895    
Ser Ser Gly Ser Pro Ala Pro Arg Asn Ser Trp Gln Lys Asp Gly Gln
            2900                2905                2910        
Pro Leu Leu Glu Asp Asp His His Lys Phe Leu Ser Asn Gly Arg Ile
        2915                2920                2925            
Leu Gln Ile Leu Asn Thr Gln Ile Thr Asp Ile Gly Arg Tyr Val Cys
    2930                2935                2940                
Val Ala Glu Asn Thr Ala Gly Ser Ala Lys Lys Tyr Phe Asn Leu Asn
2945                2950                2955                2960
Val His Val Pro Pro Ser Val Ile Gly Pro Lys Ser Glu Asn Leu Thr
                2965                2970                2975    
Val Val Val Asn Asn Phe Ile Ser Leu Thr Cys Glu Val Ser Gly Phe
            2980                2985                2990        
Pro Pro Pro Asp Leu Ser Trp Leu Lys Asn Xaa Gln Pro Ile Lys Leu
        2995                3000                3005            
Asn Thr Asn Thr Leu Ile Val Pro Gly Gly Arg Thr Leu Gln Ile Ile
    3010                3015                3020                
Arg Ala Lys Val Ser Asp Gly Gly Glu Tyr Thr Cys Ile Ala Ile Asn
3025                3030                3035                3040
Xaa Ala Gly Glu Ser Lys Lys Lys Phe Ser Leu Thr Val Tyr Val Pro
                3045                3050                3055    
Pro Ser Ile Lys Asp His Asp Ser Glu Ser Leu Ser Val Val Asn Val
            3060                3065                3070        
Arg Glu Gly Thr Ser Val Ser Leu Glu Cys Glu Ser Asn Ala Val Pro
        3075                3080                3085            
Pro Pro Val Ile Thr Trp Tyr Lys Asn Gly Arg Met Ile Thr Glu Ser
    3090                3095                3100                
Thr His Val Glu Ile Leu Ala Asp Gly Gln Met Leu His Ile Lys Lys
3105                3110                3115                3120
Ala Glu Val Ser Asp Thr Gly Gln Tyr Val Cys Arg Ala Ile Asn Val
                3125                3130                3135    
Ala Gly Arg Asp Asp Lys Asn Phe His Leu Asn Val Tyr Val Pro Pro
            3140                3145                3150        
Ser Ile Glu Gly Pro Glu Arg Glu Val Ile Val Glu Thr Ile Ser Asn
        3155                3160                3165            
Pro Val Thr Leu Thr Cys Asp Ala Thr Gly Ile Pro Pro Pro Thr Ile
    3170                3175                3180                
Ala Trp Leu Lys Asn Tyr Lys Arg Ile Glu Asn Ser Asp Ser Leu Glu
3185                3190                3195                3200
Val Arg Ile Leu Ser Gly Gly Ser Lys Leu Gln Ile Ala Arg Ser Gln
                3205                3210                3215    
His Ser Asp Ser Gly Asn Tyr Thr Cys Ile Ala Ser Asn Met Glu Gly
            3220                3225                3230        
Lys Ala Gln Lys Tyr Tyr Phe Leu Ser Ile Gln Val Pro Pro Ser Val
        3235                3240                3245            
Ala Gly Ala Glu Ile Pro Ser Asp Val Ser Val Leu Leu Gly Glu Asn
    3250                3255                3260                
Val Glu Leu Val Cys Asn Ala Asn Gly Ile Pro Thr Pro Leu Ile Gln
3265                3270                3275                3280
Trp Leu Lys Asp Gly Lys Pro Ile Ala Ser Gly Glu Thr Glu Arg Ile
                3285                3290                3295    
Arg Val Ser Ala Asn Gly Ser Thr Leu Asn Ile Tyr Gly Ala Leu Thr
            3300                3305                3310        
Ser Asp Thr Gly Lys Tyr Thr Cys Val Ala Thr Asn Pro Ala Gly Glu
        3315                3320                3325            
Glu Asp Arg Ile Phe Asn Leu Asn Val Tyr Val Thr Pro Thr Ile Arg
    3330                3335                3340                
Gly Asn Lys Asp Glu Ala Glu Lys Leu Met Thr Tyr Val Asp Thr Ser
3345                3350                3355                3360
Ile Asn Ile Glu Cys Arg Xaa Thr Gly Thr Pro Pro Pro Gln Ile Asn
                3365                3370                3375    
Trp Leu Lys Asn Gly Leu Pro Leu Pro Leu Ser Ser His Ile Arg Leu
            3380                3385                3390        
Leu Ala Ala Gly Gln Val Ile Arg Ile Val Arg Ala Gln Val Ser Asp
        3395                3400                3405            
Val Ala Val Tyr Thr Cys Val Ala Ser Asn Arg Ala Gly Val Asp Asn
    3410                3415                3420                
Lys His Tyr Asn Leu Gln Val Phe Ala Pro Pro Asn Met Asp Asn Ser
3425                3430                3435                3440
Met Gly Thr Glu Glu Ile Thr Val Leu Lys Gly Ser Ser Thr Ser Met
                3445                3450                3455    
Ala Cys Ile Thr Asp Gly Thr Pro Ala Pro Ser Met Ala Trp Leu Arg
            3460                3465                3470        
Asp Gly Gln Pro Leu Gly Leu Asp Ala His Leu Thr Val Ser Thr His
        3475                3480                3485            
Gly Met Val Leu Gln Leu Leu Lys Ala Glu Thr Glu Asp Ser Gly Lys
    3490                3495                3500                
Tyr Thr Cys Ile Ala Ser Asn Glu Ala Gly Glu Val Ser Lys His Phe
3505                3510                3515                3520
Ile Leu Lys Val Leu Glu Pro Pro His Ile Asn Gly Ser Glu Glu His
                3525                3530                3535    
Glu Glu Ile Ser Val Ile Val Asn Asn Pro Leu Glu Leu Thr Cys Ile
            3540                3545                3550        
Ala Ser Gly Ile Pro Ala Pro Lys Met Thr Trp Met Lys Asp Gly Arg
        3555                3560                3565            
Pro Leu Pro Gln Thr Asp Gln Val Gln Thr Leu Gly Gly Gly Glu Val
    3570                3575                3580                
Leu Arg Ile Ser Thr Ala Gln Val Glu Asp Thr Gly Arg Tyr Thr Cys
3585                3590                3595                3600
Leu Ala Ser Ser Pro Ala Gly Asp Asp Asp Lys Glu Tyr Leu Val Arg
                3605                3610                3615    
Val His Val Pro Pro Asn Ile Ala Gly Thr Asp Glu Pro Arg Asp Ile
            3620                3625                3630        
Thr Val Leu Arg Asn Arg Gln Val Thr Leu Glu Cys Lys Ser Asp Ala
        3635                3640                3645            
Val Pro Pro Pro Val Ile Thr Trp Leu Arg Asn Gly Glu Arg Leu Gln
    3650                3655                3660                
Ala Thr Pro Arg Val Arg Ile Leu Ser Gly Gly Arg Tyr Leu Gln Ile
3665                3670                3675                3680
Asn Asn Ala Asp Leu Gly Asp Thr Ala Asn Tyr Thr Cys Val Ala Ser
                3685                3690                3695    
Asn Ile Ala Gly Lys Thr Thr Arg Glu Phe Ile Leu Thr Val Asn Val
            3700                3705                3710        
Pro Pro Asn Ile Lys Gly Gly Pro Gln Ser Leu Val Ile Leu Leu Asn
        3715                3720                3725            
Lys Ser Thr Val Leu Glu Cys Ile Ala Glu Gly Val Pro Thr Pro Arg
    3730                3735                3740                
Ile Thr Trp Arg Lys Asp Gly Ala Val Leu Ala Gly Asn His Ala Arg
3745                3750                3755                3760
Tyr Ser Ile Leu Glu Asn Gly Phe Leu His Ile Gln Ser Ala His Val
                3765                3770                3775    
Thr Asp Thr Gly Arg Tyr Leu Cys Met Ala Thr Asn Ala Ala Gly Thr
            3780                3785                3790        
Asp Arg Arg Arg Ile Asp Leu Gln Val His Val Pro Pro Ser Ile Ala
        3795                3800                3805            
Pro Gly Pro Thr Asn Met Thr Val Ile Val Asn Val Gln Thr Thr Leu
    3810                3815                3820                
Ala Cys Glu Ala Thr Gly Ile Pro Lys Pro Ser Ile Asn Trp Arg Lys
3825                3830                3835                3840
Asn Gly His Leu Leu Asn Val Asp Gln Asn Gln Asn Ser Tyr Arg Leu
                3845                3850                3855    
Leu Ser Ser Gly Ser Leu Val Ile Ile Ser Pro Ser Val Asp Asp Thr
            3860                3865                3870        
Ala Thr Tyr Glu Cys Thr Val Thr Asn Gly Ala Gly Asp Asp Lys Arg
        3875                3880                3885            
Thr Val Asp Leu Thr Val Gln Val Pro Pro Ser Ile Ala Asp Glu Pro
    3890                3895                3900                
Thr Asp Phe Leu Val Thr Lys His Ala Pro Ala Val Ile Thr Cys Thr
3905                3910                3915                3920
Ala Ser Gly Val Pro Phe Pro Ser Ile His Trp Thr Lys Asn Gly Ile
                3925                3930                3935    
Arg Leu Leu Pro Arg Gly Asp Gly Tyr Arg Ile Leu Ser Ser Gly Ala
            3940                3945                3950        
Ile Glu Ile Leu Ala Thr Gln Leu Asn His Ala Gly Arg Tyr Thr Cys
        3955                3960                3965            
Val Ala Arg Asn Ala Ala Gly Ser Ala His Arg His Val Thr Leu His
    3970                3975                3980                
Val His Glu Pro Pro Val Ile Gln Pro Gln Pro Ser Glu Leu His Val
3985                3990                3995                4000
Ile Leu Asn Asn Pro Ile Leu Leu Pro Cys Glu Ala Thr Gly Thr Pro
                4005                4010                4015    
Ser Pro Phe Ile Thr Trp Gln Lys Glu Gly Ile Asn Val Asn Thr Ser
            4020                4025                4030        
Gly Arg Asn His Ala Val Leu Pro Ser Gly Gly Leu Gln Ile Ser Arg
        4035                4040                4045            
Ala Val Arg Glu Asp Ala Gly Thr Tyr Met Cys Val Ala Gln Asn Pro
    4050                4055                4060                
Ala Gly Thr Ala Leu Gly Lys Ile Lys Leu Asn Val Gln Val Pro Pro
4065                4070                4075                4080
Val Ile Ser Pro His Leu Lys Glu Tyr Val Ile Ala Val Asp Lys Pro
                4085                4090                4095    
Ile Thr Leu Ser Cys Glu Ala Asp Gly Leu Pro Pro Pro Asp Ile Thr
            4100                4105                4110        
Trp His Lys Asp Gly Arg Ala Ile Val Glu Ser Ile Arg Gln Arg Val
        4115                4120                4125            
Leu Ser Ser Gly Ser Leu Gln Ile Ala Phe Val Gln Pro Gly Asp Ala
    4130                4135                4140                
Gly His Tyr Thr Cys Met Ala Ala Asn Val Ala Gly Ser Ser Ser Thr
4145                4150                4155                4160
Ser Thr Lys Leu Thr Val His Val Pro Pro Arg Ile Arg Ser Thr Glu
                4165                4170                4175    
Gly His Tyr Thr Val Asn Glu Asn Ser Gln Ala Ile Leu Pro Cys Val
            4180                4185                4190        
Ala Asp Gly Ile Pro Thr Pro Ala Ile Asn Trp Lys Lys Asp Asn Val
        4195                4200                4205            
Leu Leu Ala Asn Leu Leu Gly Lys Tyr Thr Ala Glu Pro Tyr Gly Glu
    4210                4215                4220                
Leu Ile Leu Glu Asn Val Val Leu Glu Asp Ser Gly Phe Tyr Thr Cys
4225                4230                4235                4240
Val Ala Asn Asn Ala Ala Gly Glu Asp Thr His Thr Val Ser Leu Thr
                4245                4250                4255    
Val His Val Leu Pro Thr Phe Thr Glu Leu Pro Gly Asp Val Ser Leu
            4260                4265                4270        
Asn Lys Gly Glu Gln Leu Arg Leu Ser Cys Lys Ala Thr Gly Ile Pro
        4275                4280                4285            
Leu Pro Lys Leu Thr Trp Thr Phe Asn Asn Asn Ile Ile Pro Ala His
    4290                4295                4300                
Phe Asp Ser Val Asn Gly His Ser Glu Leu Val Ile Glu Arg Val Ser
4305                4310                4315                4320
Lys Glu Asp Ser Gly Thr Tyr Val Cys Thr Ala Glu Asn Ser Val Gly
                4325                4330                4335    
Phe Val Lys Ala Thr Gly Phe Val Tyr Val Lys Glu Pro Pro Val Phe
            4340                4345                4350        
Lys Gly Asp Tyr Pro Ser Asn Trp Ile Glu Pro Leu Gly Gly Asn Ala
        4355                4360                4365            
Ile Leu Asn Cys Glu Val Lys Gly Asp Pro Thr Pro Thr Ile Gln Trp
    4370                4375                4380                
Asn Arg Lys Gly Val Asp Ile Glu Ile Ser His Arg Ile Arg Gln Leu
4385                4390                4395                4400
Gly Asn Gly Ser Leu Ala Ile Tyr Gly Thr Val Asn Glu Asp Ala Gly
                4405                4410                4415    
Asp Tyr Thr Cys Val Ala Thr Asn Glu Ala Gly Val Val Glu Arg Ser
            4420                4425                4430        
Met Ser Leu Thr Leu Gln Ser Pro Pro Ile Ile Thr Leu Glu Pro Val
        4435                4440                4445            
Glu Thr Val Ile Asn Ala Gly Gly Lys Ile Ile Leu Asn Cys Gln Ala
    4450                4455                4460                
Thr Gly Glu Pro Gln Pro Thr Ile Thr Trp Ser Arg Gln Gly His Ser
4465                4470                4475                4480
Ile Ser Trp Asp Asp Arg Val Asn Val Leu Ser Asn Asn Ser Leu Tyr
                4485                4490                4495    
Ile Ala Asp Ala Gln Lys Glu Asp Thr Ser Glu Phe Glu Cys Val Ala
            4500                4505                4510        
Arg Asn Leu Met Gly Ser Val Leu Val Arg Val Pro Val Ile Val Gln
        4515                4520                4525            
Val His Gly Gly Phe Ser Gln Trp Ser Ala Trp Arg Ala Cys Ser Val
    4530                4535                4540                
Thr Cys Gly Lys Gly Ile Gln Lys Arg Ser Arg Leu Cys Asn Gln Pro
4545                4550                4555                4560
Leu Pro Ala Asn Gly Gly Lys Pro Cys Gln Gly Ser Asp Leu Glu Met
                4565                4570                4575    
Arg Asn Cys Gln Asn Lys Pro Cys Pro Val Asp Gly Ser Trp Ser Glu
            4580                4585                4590        
Trp Ser Leu Trp Glu Glu Cys Thr Arg Ser Cys Gly Arg Gly Asn Gln
        4595                4600                4605            
Thr Arg Thr Arg Thr Cys Asn Asn Pro Ser Val Gln His Gly Gly Arg
    4610                4615                4620                
Pro Cys Glu Gly Asn Ala Val Glu Ile Ile Met Cys Asn Ile Arg Pro
4625                4630                4635                4640
Cys Pro Val His Gly Ala Trp Ser Ala Trp Gln Pro Trp Gly Thr Cys
                4645                4650                4655    
Ser Glu Ser Cys Gly Lys Gly Thr Gln Thr Arg Ala Arg Leu Cys Asn
            4660                4665                4670        
Asn Pro Pro Pro Ala Phe Gly Gly Ser Tyr Cys Asp Gly Ala Glu Thr
        4675                4680                4685            
Gln Met Gln Val Cys Asn Glu Arg Asn Cys Pro Ile His Gly Lys Trp
    4690                4695                4700                
Ala Thr Trp Ala Ser Trp Ser Ala Cys Ser Val Ser Cys Gly Gly Gly
4705                4710                4715                4720
Ala Arg Gln Arg Thr Arg Gly Cys Ser Asp Pro Val Pro Gln Tyr Gly
                4725                4730                4735    
Gly Arg Lys Cys Glu Gly Ser Asp Val Gln Ser Asp Phe Cys Asn Ser
            4740                4745                4750        
Asp Pro Cys Pro Thr His Gly Asn Trp Ser Pro Trp Ser Gly Trp Gly
        4755                4760                4765            
Thr Cys Ser Arg Thr Cys Asn Gly Gly Gln Met Arg Arg Tyr Arg Thr
    4770                4775                4780                
Cys Asp Asn Pro Pro Pro Ser Asn Gly Gly Arg Ala Cys Gly Gly Pro
4785                4790                4795                4800
Asp Ser Gln Ile Gln Arg Cys Asn Thr Asp Met Cys Pro Val Asp Gly
                4805                4810                4815    
Ser Trp Gly Ser Trp His Ser Trp Ser Gln Cys Ser Ala Ser Cys Gly
            4820                4825                4830        
Gly Gly Glu Lys Thr Arg Lys Arg Leu Cys Asp His Pro Val Pro Val
        4835                4840                4845            
Lys Gly Gly Arg Pro Cys Pro Gly Asp Thr Thr Gln Val Thr Arg Cys
    4850                4855                4860                
Asn Val Gln Ala Cys Pro Gly Gly Pro Gln Arg Ala Arg Gly Ser Val
4865                4870                4875                4880
Ile Gly Asn Ile Asn Asp Val Glu Phe Gly Ile Ala Phe Leu Asn Ala
                4885                4890                4895    
Thr Ile Thr Asp Ser Pro Asn Ser Asp Thr Arg Ile Ile Arg Ala Lys
            4900                4905                4910        
Ile Thr Asn Val Pro Arg Ser Leu Gly Ser Ala Met Arg Lys Ile Val
        4915                4920                4925            
Ser Ile Leu Asn Pro Ile Tyr Trp Thr Thr Ala Lys Glu Ile Gly Glu
    4930                4935                4940                
Ala Val Asn Gly Phe Thr Leu Thr Asn Ala Val Phe Lys Arg Glu Thr
4945                4950                4955                4960
Gln Val Glu Phe Ala Thr Gly Glu Ile Leu Gln Met Ser His Ile Ala
                4965                4970                4975    
Arg Gly Leu Asp Ser Asp Gly Ser Leu Leu Leu Asp Ile Val Val Ser
            4980                4985                4990        
Gly Tyr Val Leu Gln Leu Gln Ser Pro Ala Glu Val Thr Val Lys Asp
        4995                5000                5005            
Tyr Thr Glu Asp Tyr Ile Gln Thr Gly Pro Gly Gln Leu Tyr Ala Tyr
    5010                5015                5020                
Ser Thr Arg Leu Phe Thr Ile Asp Gly Ile Ser Ile Pro Tyr Thr Trp
5025                5030                5035                5040
Asn His Thr Val Phe Tyr Asp Gln Ala Gln Gly Arg Met Pro Phe Leu
                5045                5050                5055    
Val Glu Thr Leu His Ala Ser Ser Val Glu Ser Asp Tyr Asn Gln Ile
            5060                5065                5070        
Glu Glu Thr Leu Gly Phe Lys Ile His Ala Ser Ile Ser Lys Gly Asp
        5075                5080                5085            
Arg Ser Asn Gln Cys Pro Ser Gly Phe Thr Leu Asp Ser Val Gly Pro
    5090                5095                5100                
Phe Cys Ala Asp Glu Asp Glu Cys Ala Ala Gly Asn Pro Cys Ser His
5105                5110                5115                5120
Ser Cys His Asn Ala Met Gly Thr Tyr Tyr Cys Ser Cys Pro Lys Gly
                5125                5130                5135    
Leu Thr Ile Ala Ala Asp Gly Arg Thr Cys Gln Asp Ile Asp Glu Cys
            5140                5145                5150        
Ala Leu Gly Arg His Thr Cys His Ala Gly Gln Asp Cys Asp Asn Thr
        5155                5160                5165            
Ile Gly Ser Tyr Arg Cys Val Val Arg Cys Gly Ser Gly Phe Arg Arg
    5170                5175                5180                
Thr Ser Asp Gly Leu Ser Cys Gln Asp Ile Asn Glu Cys Gln Glu Ser
5185                5190                5195                5200
Ser Pro Cys His Gln Arg Cys Phe Asn Ala Ile Gly Ser Phe His Cys
                5205                5210                5215    
Gly Cys Glu Pro Gly Tyr Gln Leu Lys Gly Arg Lys Cys Met Asp Val
            5220                5225                5230        
Asn Glu Cys Arg Gln Asn Val Cys Arg Pro Asp Gln His Cys Lys Asn
        5235                5240                5245            
Thr Arg Gly Gly Tyr Lys Cys Ile Asp Leu Cys Pro Asn Gly Met Thr
    5250                5255                5260                
Lys Ala Glu Asn Gly Thr Cys Ile Asp Ile Asp Glu Cys Lys Asp Gly
5265                5270                5275                5280
Thr His Gln Cys Arg Tyr Asn Gln Ile Cys Glu Asn Thr Arg Ser Ser
                5285                5290                5295    
Tyr Arg Cys Val Cys Pro Arg Gly Tyr Arg Ser Gln Gly Val Gly Arg
            5300                5305                5310        
Pro Cys Met Asp Ile Asp Glu Cys Glu Gln Val Pro Lys Pro Cys Ala
        5315                5320                5325            
His Gln Cys Ser Asn Thr Pro Gly Ser Phe Lys Cys Ile Cys Pro Pro
    5330                5335                5340                
Gly Gln His Leu Leu Gly Asp Gly Lys Ser Cys Ala Gly Leu Glu Arg
5345                5350                5355                5360
Leu Pro Asn Tyr Gly Thr Gln Tyr Ser Ser Tyr Asn Leu Ala Arg Phe
                5365                5370                5375    
Ser Pro Val Arg Asn Asn Tyr Gln Pro Gln Gln His Tyr Arg Gln Tyr
            5380                5385                5390        
Ser His Leu Tyr Ser Ser Tyr Ser Glu Tyr Arg Asn Ser Arg Thr Ser
        5395                5400                5405            
Leu Ser Arg Thr Arg Arg Thr Ile Arg Lys Thr Cys Pro Glu Gly Ser
    5410                5415                5420                
Glu Ala Ser His Asp Thr Cys Val Asp Ile Asp Glu Cys Glu Asn Thr
5425                5430                5435                5440
Asp Ala Cys Gln His Glu Cys Lys Asn Thr Phe Gly Ser Tyr Gln Cys
                5445                5450                5455    
Ile Cys Pro Pro Gly Tyr Gln Leu Thr His Asn Gly Lys Thr Cys Gln
            5460                5465                5470        
Asp Ile Asp Glu Cys Leu Glu Gln Asn Val His Cys Gly Pro Asn Arg
        5475                5480                5485            
Met Cys Phe Asn Met Arg Gly Ser Tyr Gln Cys Ile Asp Thr Pro Cys
    5490                5495                5500                
Pro Pro Asn Tyr Gln Arg Asp Pro Val Ser Gly Phe Cys Leu Lys Asn
5505                5510                5515                5520
Cys Pro Pro Asn Asp Leu Glu Cys Ala Leu Ser Pro Tyr Ala Leu Glu
                5525                5530                5535    
Tyr Lys Leu Val Ser Leu Pro Phe Gly Ile Ala Thr Asn Gln Asp Leu
            5540                5545                5550        
Ile Arg Leu Val Ala Tyr Thr Gln Asp Gly Val Met His Pro Arg Thr
        5555                5560                5565            
Thr Phe Leu Met Val Asp Glu Glu Gln Thr Val Pro Phe Ala Leu Arg
    5570                5575                5580                
Asp Glu Asn Leu Lys Gly Val Val Tyr Thr Thr Arg Pro Leu Arg Glu
5585                5590                5595                5600
Ala Glu Thr Tyr Arg Met Arg Val Arg Ala Ser Ser Tyr Ser Ala Asn
                5605                5610                5615    
Gly Thr Ile Glu Tyr Gln Thr Thr Phe Ile Val Tyr Ile Ala Val Ser
            5620                5625                5630        
Ala Tyr Pro Tyr
        5635    


<210> 1896
<211> 303
<212> PRT
<213> Homo sapiens

<400> 1896
Met Ser Glu Ala Gly Glu Ala Thr Thr Thr Thr Thr Thr Thr Leu Pro
 1               5                  10                  15      
Gln Ala Pro Thr Glu Ala Ala Ala Ala Ala Pro Gln Asp Pro Ala Pro
            20                  25                  30          
Lys Ser Pro Val Gly Ser Gly Ala Pro Gln Ala Ala Ala Pro Ala Pro
        35                  40                  45              
Ala Ala His Val Ala Gly Asn Pro Gly Gly Asp Ala Ala Pro Ala Ala
    50                  55                  60                  
Thr Gly Thr Ala Ala Ala Ala Ser Leu Ala Ala Ala Ala Gly Ser Glu
65                  70                  75                  80  
Asp Ala Glu Lys Lys Val Leu Ala Thr Lys Val Leu Gly Thr Val Lys
                85                  90                  95      
Trp Phe Asn Val Arg Asn Gly Tyr Gly Phe Ile Asn Arg Asn Asp Thr
            100                 105                 110         
Lys Glu Asp Val Phe Val His Gln Thr Ala Ile Lys Lys Asn Asn Pro
        115                 120                 125             
Arg Lys Tyr Leu Arg Ser Leu Gly Asp Gly Glu Thr Val Glu Phe Asp
    130                 135                 140                 
Val Val Glu Gly Glu Lys Gly Ala Glu Ala Ala Asn Val Thr Gly Pro
145                 150                 155                 160 
Asp Gly Val Pro Val Glu Gly Ser Arg Tyr Ala Ala Asp Arg Arg Arg
                165                 170                 175     
Tyr Arg Arg Gly Tyr Tyr Gly Arg Arg Arg Gly Pro Pro Arg Asn Ala
            180                 185                 190         
Gly Glu Ile Gly Glu Met Lys Asp Gly Val Pro Glu Gly Ala Gln Leu
        195                 200                 205             
Gln Gly Pro Val His Arg Asn Pro Thr Tyr Arg Pro Arg Tyr Arg Ser
    210                 215                 220                 
Arg Gly Pro Pro Arg Pro Arg Pro Ala Pro Ala Val Gly Glu Ala Glu
225                 230                 235                 240 
Asp Lys Glu Asn Gln Gln Ala Thr Ser Gly Pro Asn Gln Pro Ser Val
                245                 250                 255     
Arg Arg Gly Tyr Arg Arg Pro Tyr Asn Tyr Arg Arg Arg Pro Arg Pro
            260                 265                 270         
Pro Asn Ala Pro Ser Gln Asp Gly Lys Glu Ala Lys Ala Gly Glu Ala
        275                 280                 285             
Pro Thr Glu Asn Pro Ala Pro Pro Thr Gln Gln Ser Ser Ala Glu
    290                 295                 300             


<210> 1897
<211> 721
<212> PRT
<213> Homo sapiens

<400> 1897
Gly Thr Arg Leu Asn Leu Ser Cys Ala Asp Val Val Trp His Gln Met
 1               5                  10                  15      
Asp Glu Asn Leu Leu Ala Thr Ala Ala Thr Asn Gly Val Val Val Thr
            20                  25                  30          
Trp Asn Leu Gly Arg Pro Ser Arg Asn Lys Gln Asp Gln Leu Phe Thr
        35                  40                  45              
Glu His Lys Arg Thr Val Asn Lys Val Cys Phe His Pro Thr Glu Ala
    50                  55                  60                  
His Val Leu Leu Ser Gly Ser Gln Asp Gly Phe Met Lys Cys Phe Asp
65                  70                  75                  80  
Leu Arg Arg Lys Asp Ser Val Ser Thr Phe Ser Gly Gln Ser Glu Ser
                85                  90                  95      
Val Arg Asp Val Gln Phe Ser Ile Arg Asp Tyr Phe Thr Phe Ala Ser
            100                 105                 110         
Thr Phe Glu Asn Gly Asn Val Gln Leu Trp Asp Ile Arg Arg Pro Asp
        115                 120                 125             
Arg Cys Glu Arg Met Phe Thr Ala His Asn Gly Pro Val Phe Cys Cys
    130                 135                 140                 
Asp Trp His Pro Glu Asp Arg Gly Trp Leu Ala Thr Gly Gly Arg Asp
145                 150                 155                 160 
Lys Met Val Lys Val Trp Asp Met Thr Thr His Arg Ala Lys Glu Met
                165                 170                 175     
His Cys Val Gln Thr Ile Ala Ser Val Ala Arg Val Lys Trp Arg Pro
            180                 185                 190         
Glu Cys Arg His His Leu Ala Thr Cys Ser Met Met Val Asp His Asn
        195                 200                 205             
Ile Tyr Val Trp Asp Val Arg Arg Pro Phe Val Pro Ala Ala Met Phe
    210                 215                 220                 
Glu Glu His Arg Asp Val Thr Thr Gly Ile Ala Trp Arg His Pro His
225                 230                 235                 240 
Asp Pro Ser Phe Leu Leu Ser Gly Ser Lys Asp Ser Ser Leu Cys Gln
                245                 250                 255     
His Leu Phe Arg Asp Ala Ser Gln Pro Val Glu Arg Ala Asn Pro Glu
            260                 265                 270         
Gly Leu Cys Tyr Gly Leu Phe Gly Asp Leu Ala Phe Ala Ala Lys Glu
        275                 280                 285             
Ser Leu Val Ala Ala Glu Ser Gly Arg Lys Pro Tyr Thr Gly Asp Arg
    290                 295                 300                 
Arg His Pro Ile Phe Phe Lys Arg Lys Leu Asp Pro Ala Glu Pro Phe
305                 310                 315                 320 
Ala Gly Leu Ala Ser Ser Ala Leu Ser Val Phe Glu Thr Glu Pro Gly
                325                 330                 335     
Gly Gly Gly Met Arg Trp Phe Val Asp Thr Ala Glu Arg Tyr Ala Leu
            340                 345                 350         
Ala Gly Arg Pro Leu Ala Glu Leu Cys Asp His Asn Ala Lys Val Ala
        355                 360                 365             
Arg Glu Leu Gly Arg Asn Gln Val Ala Gln Thr Trp Thr Met Leu Arg
    370                 375                 380                 
Ile Ile Tyr Cys Ser Pro Gly Leu Val Pro Thr Ala Asn Leu Asn His
385                 390                 395                 400 
Ser Val Gly Lys Gly Gly Ser Cys Gly Leu Pro Leu Met Asn Ser Phe
                405                 410                 415     
Asn Leu Lys Asp Met Ala Pro Gly Leu Gly Ser Glu Thr Arg Leu Asp
            420                 425                 430         
Arg Ser Lys Gly Asp Ala Arg Ser Asp Thr Val Leu Leu Asp Ser Ser
        435                 440                 445             
Ala Thr Leu Ile Thr Asn Glu Asp Asn Glu Glu Thr Glu Gly Ser Asp
    450                 455                 460                 
Val Pro Ala Asp Tyr Leu Leu Gly Asp Val Glu Gly Glu Glu Asp Glu
465                 470                 475                 480 
Leu Tyr Leu Leu Asp Pro Glu His Ala His Pro Glu Asp Pro Glu Cys
                485                 490                 495     
Val Leu Pro Gln Glu Ala Phe Pro Leu Arg His Glu Ile Val Asp Thr
            500                 505                 510         
Pro Pro Gly Pro Glu His Leu Gln Asp Lys Ala Asp Ser Pro His Val
        515                 520                 525             
Ser Gly Ser Glu Ala Asp Val Ala Ser Leu Ala Pro Val Asp Ser Ser
    530                 535                 540                 
Phe Ser Leu Leu Ser Val Ser His Ala Leu Tyr Asp Ser Arg Leu Pro
545                 550                 555                 560 
Pro Asp Phe Phe Gly Val Leu Val Arg Asp Met Leu His Phe Tyr Ala
                565                 570                 575     
Glu Gln Gly Asp Val Gln Met Ala Val Ser Val Leu Ile Val Leu Gly
            580                 585                 590         
Glu Arg Val Arg Lys Asp Ile Asp Glu Gln Thr Gln Glu His Trp Tyr
        595                 600                 605             
Thr Ser Tyr Ile Asp Leu Leu Gln Arg Phe Arg Leu Trp Asn Val Ser
    610                 615                 620                 
Asn Glu Val Val Lys Leu Ser Thr Ser Arg Ala Val Ser Cys Leu Asn
625                 630                 635                 640 
Gln Ala Ser Thr Thr Leu His Val Asn Cys Ser His Cys Lys Arg Pro
                645                 650                 655     
Met Ser Ser Arg Gly Trp Val Cys Asp Arg Cys His Arg Cys Ala Ser
            660                 665                 670         
Met Cys Ala Val Cys His His Val Val Lys Gly Leu Phe Val Trp Cys
        675                 680                 685             
Gln Gly Cys Ser His Gly Gly His Leu Gln His Ile Met Lys Trp Leu
    690                 695                 700                 
Glu Gly Ser Ser His Cys Pro Ala Gly Cys Gly His Leu Cys Glu Tyr
705                 710                 715                 720 
Ser
    


<210> 1898
<211> 128
<212> PRT
<213> Homo sapiens

<400> 1898
His Glu Asp His Pro Asp Lys Asn Pro Asp Asn Pro Glu Ala Ala Asp
 1               5                  10                  15      
Lys Phe Lys Glu Ile Asn Asn Ala His Ala Ile Leu Thr Asp Ala Thr
            20                  25                  30          
Lys Arg Asn Ile Tyr Asp Lys Tyr Gly Ser Leu Gly Leu Tyr Val Ala
        35                  40                  45              
Glu Gln Phe Gly Glu Glu Asn Val Asn Thr Tyr Phe Val Leu Ser Ser
    50                  55                  60                  
Trp Trp Ala Lys Ala Leu Phe Val Phe Cys Gly Leu Leu Thr Cys Cys
65                  70                  75                  80  
Tyr Cys Cys Cys Cys Leu Cys Cys Cys Phe Asn Cys Cys Cys Gly Lys
                85                  90                  95      
Cys Lys Pro Lys Ala Pro Glu Gly Glu Glu Thr Glu Phe Tyr Val Ser
            100                 105                 110         
Pro Glu Asp Leu Glu Ala Gln Leu Gln Ser Asp Glu Arg Gly Gly His
        115                 120                 125             


<210> 1899
<211> 39
<212> PRT
<213> Homo sapiens

<400> 1899
Arg Gly Gly Arg Pro Arg Gly Lys Leu Glu Ala Arg Val Gly Asn Met
 1               5                  10                  15      
Ser Glu Ser Glu Leu Gly Arg Lys Trp Asp Arg Cys Leu Ala Asp Ala
            20                  25                  30          
Val Val Lys Ile Glu Ser Trp
        35                  


<210> 1900
<211> 583
<212> PRT
<213> Homo sapiens

<400> 1900
His Glu Gly His Trp Leu Pro Ala Ala Arg Gly Arg Leu Glu Gln Leu
 1               5                  10                  15      
Gly Gly Leu Leu Ala Asn Val Ser Gly Glu Leu Gly Gly Arg Leu Asp
            20                  25                  30          
Leu Leu Glu Glu Gln Val Ala Gly Ala Met Gln Ala Cys Gly Gln Leu
        35                  40                  45              
Cys Ser Gly Ala Pro Gly Glu Gln Asp Ser Gln Val Ser Glu Ile Leu
    50                  55                  60                  
Ser Ala Leu Glu Arg Arg Val Leu Asp Ser Glu Gly Gln Leu Arg Leu
65                  70                  75                  80  
Val Gly Ser Gly Leu His Thr Val Glu Ala Ala Gly Glu Ala Arg Gln
                85                  90                  95      
Ala Thr Leu Glu Gly Leu Gln Glu Val Val Gly Arg Leu Gln Asp Arg
            100                 105                 110         
Val Asp Ala Gln Asp Glu Thr Ala Ala Glu Phe Thr Leu Arg Leu Asn
        115                 120                 125             
Leu Thr Ala Ala Arg Leu Gly Gln Leu Glu Gly Leu Leu Gln Ala His
    130                 135                 140                 
Gly Asp Glu Gly Cys Gly Ala Cys Gly Gly Val Gln Glu Glu Leu Gly
145                 150                 155                 160 
Arg Leu Arg Asp Gly Val Glu Arg Cys Ser Cys Pro Leu Leu Pro Pro
                165                 170                 175     
Arg Gly Pro Gly Ala Gly Pro Gly Val Gly Gly Pro Ser Arg Gly Pro
            180                 185                 190         
Leu Asp Gly Phe Ser Val Phe Gly Gly Ser Ser Gly Ser Ala Leu Gln
        195                 200                 205             
Ala Leu Gln Gly Glu Leu Ser Glu Val Ile Leu Ser Phe Ser Ser Leu
    210                 215                 220                 
Asn Asp Ser Leu Asn Glu Leu Gln Thr Thr Val Glu Gly Gln Gly Ala
225                 230                 235                 240 
Asp Leu Ala Asp Leu Gly Ala Thr Lys Asp Arg Ile Ile Ser Glu Ile
                245                 250                 255     
Asn Arg Leu Gln Gln Glu Ala Thr Glu His Ala Thr Glu Ser Glu Glu
            260                 265                 270         
Arg Phe Arg Gly Leu Glu Glu Gly Gln Ala Gln Ala Gly Gln Cys Pro
        275                 280                 285             
Ser Leu Glu Gly Arg Leu Gly Arg Leu Glu Gly Val Cys Glu Arg Leu
    290                 295                 300                 
Asp Thr Val Ala Gly Gly Leu Gln Gly Leu Arg Glu Gly Leu Ser Arg
305                 310                 315                 320 
His Val Ala Gly Leu Trp Ala Gly Leu Arg Glu Thr Asn Thr Thr Ser
                325                 330                 335     
Gln Met Gln Ala Ala Leu Leu Glu Lys Leu Val Gly Gly Gln Ala Gly
            340                 345                 350         
Leu Gly Arg Arg Leu Gly Ala Leu Asn Ser Ser Leu Gln Leu Leu Glu
        355                 360                 365             
Asp Arg Leu His Gln Leu Ser Leu Lys Asp Leu Thr Gly Pro Ala Gly
    370                 375                 380                 
Glu Ala Gly Pro Pro Gly Pro Pro Gly Leu Gln Gly Pro Pro Gly Pro
385                 390                 395                 400 
Ala Gly Pro Pro Gly Ser Pro Gly Lys Asp Gly Gln Glu Gly Pro Ile
                405                 410                 415     
Gly Pro Pro Gly Pro Gln Gly Glu Gln Gly Val Glu Gly Ala Pro Ala
            420                 425                 430         
Ala Pro Val Pro Gln Val Ala Phe Ser Ala Ala Leu Ser Leu Pro Arg
        435                 440                 445             
Ser Glu Pro Gly Thr Val Pro Phe Asp Arg Val Leu Leu Asn Asp Gly
    450                 455                 460                 
Gly Tyr Tyr Asp Pro Glu Thr Gly Val Phe Thr Ala Pro Leu Ala Gly
465                 470                 475                 480 
Arg Tyr Leu Leu Ser Ala Val Leu Thr Gly His Arg His Glu Lys Val
                485                 490                 495     
Glu Ala Val Leu Ser Arg Ser Asn Gln Gly Val Ala Arg Val Asp Ser
            500                 505                 510         
Gly Gly Tyr Glu Pro Glu Gly Leu Glu Asn Lys Pro Val Ala Glu Ser
        515                 520                 525             
Gln Pro Ser Pro Gly Thr Leu Gly Val Phe Ser Leu Ile Leu Pro Leu
    530                 535                 540                 
Gln Ala Gly Asp Thr Val Cys Val Asp Leu Val Met Gly Gln Leu Ala
545                 550                 555                 560 
His Ser Glu Glu Pro Leu Thr Ile Phe Ser Gly Ala Leu Leu Tyr Gly
                565                 570                 575     
Asp Pro Glu Leu Glu His Ala
            580             


<210> 1901
<211> 575
<212> PRT
<213> Homo sapiens

<400> 1901
Met Ala Lys Pro Phe Phe Arg Leu Gln Lys Phe Leu Arg Arg Thr Gln
 1               5                  10                  15      
Phe Leu Leu Phe Phe Leu Thr Ala Ala Tyr Leu Met Thr Gly Ser Leu
            20                  25                  30          
Leu Leu Leu Gln Arg Val Arg Val Ala Leu Pro Gln Gly Pro Arg Ala
        35                  40                  45              
Pro Gly Pro Leu Gln Thr Leu Pro Val Ala Ala Val Ala Leu Gly Val
    50                  55                  60                  
Gly Leu Leu Asp Ser Arg Ala Leu His Asp Pro Arg Val Ser Pro Glu
65                  70                  75                  80  
Leu Leu Leu Gly Val Asp Met Leu Gln Ser Pro Leu Thr Arg Pro Arg
                85                  90                  95      
Pro Gly Pro Arg Trp Leu Arg Ser Arg Asn Ser Glu Leu Arg Gln Leu
            100                 105                 110         
Arg Arg Arg Trp Phe His His Phe Met Ser Asp Ser Gln Gly Pro Pro
        115                 120                 125             
Ala Leu Gly Pro Glu Ala Ala Arg Pro Ala Ile His Ser Arg Gly Thr
    130                 135                 140                 
Tyr Ile Gly Cys Phe Ser Asp Asp Gly His Glu Arg Thr Leu Lys Gly
145                 150                 155                 160 
Ala Val Phe Tyr Asp Leu Arg Lys Met Thr Val Ser His Cys Gln Asp
                165                 170                 175     
Ala Cys Ala Glu Arg Ser Tyr Val Tyr Ala Gly Leu Glu Ala Gly Ala
            180                 185                 190         
Glu Cys Tyr Cys Gly Asn Arg Leu Pro Ala Val Ser Val Gly Leu Glu
        195                 200                 205             
Glu Cys Asn Tyr Glu Cys Lys Gly Glu Lys Gly Ser Val Cys Gly Ala
    210                 215                 220                 
Val Asp Arg Leu Ser Val Tyr Arg Val Asp Glu Leu Gln Pro Gly Ser
225                 230                 235                 240 
Arg Lys Arg Arg Thr Ala Thr Tyr Arg Gly Cys Phe Arg Leu Pro Glu
                245                 250                 255     
Asn Ile Thr His Ala Phe Pro Ser Ser Leu Ile Gln Ala Asn Val Thr
            260                 265                 270         
Val Gly Thr Cys Ser Gly Phe Cys Ser Gln Lys Glu Phe Pro Leu Ala
        275                 280                 285             
Ile Leu Arg Gly Trp Glu Cys Tyr Cys Ala Tyr Pro Thr Pro Arg Phe
    290                 295                 300                 
Asn Leu Arg Asp Ala Met Asp Ser Ser Val Cys Gly Gln Asp Pro Glu
305                 310                 315                 320 
Ala Gln Arg Leu Ala Glu Tyr Cys Glu Val Tyr Gln Thr Pro Val Gln
                325                 330                 335     
Asp Thr Arg Cys Thr Asp Arg Arg Phe Leu Pro Asn Lys Ser Lys Val
            340                 345                 350         
Phe Val Ala Leu Ser Ser Phe Pro Gly Ala Gly Asn Thr Trp Ala Arg
        355                 360                 365             
His Leu Ile Glu His Ala Thr Gly Phe Tyr Thr Gly Ser Tyr Tyr Phe
    370                 375                 380                 
Asp Gly Thr Leu Tyr Asn Lys Gly Phe Lys Gly Glu Lys Asp His Trp
385                 390                 395                 400 
Arg Ser Arg Arg Thr Ile Cys Val Lys Thr His Glu Ser Gly Arg Arg
                405                 410                 415     
Glu Ile Glu Met Phe Asp Ser Ala Ile Leu Leu Ile Arg Asn Pro Tyr
            420                 425                 430         
Arg Ser Leu Val Ala Glu Phe Asn Arg Lys Cys Ala Gly His Leu Gly
        435                 440                 445             
Tyr Ala Ala Asp Arg Asn Trp Lys Ser Lys Glu Trp Pro Asp Phe Val
    450                 455                 460                 
Asn Ser Tyr Ala Ser Trp Trp Ser Ser His Val Leu Asp Trp Leu Lys
465                 470                 475                 480 
Tyr Gly Lys Arg Leu Leu Val Val His Tyr Glu Glu Leu Arg Arg Ser
                485                 490                 495     
Leu Val Pro Thr Leu Arg Glu Met Val Ala Phe Leu Asn Val Ser Val
            500                 505                 510         
Ser Glu Glu Arg Leu Leu Cys Val Glu Asn Asn Lys Glu Gly Ser Phe
        515                 520                 525             
Arg Arg Arg Gly Arg Arg Ser His Asp Pro Glu Pro Phe Thr Pro Glu
    530                 535                 540                 
Met Lys Asp Leu Ile Asn Gly Tyr Ile Arg Thr Val Asp Gln Ala Leu
545                 550                 555                 560 
Arg Asp His Asn Trp Thr Gly Leu Pro Arg Glu Tyr Val Pro Arg
                565                 570                 575 


<210> 1902
<211> 536
<212> PRT
<213> Homo sapiens

<400> 1902
Met Arg Asp Ser Thr Gly Ala Gly Asn Ser Leu Val His Lys Arg Ser
 1               5                  10                  15      
Pro Leu Arg Arg Asn Gln Lys Thr Pro Thr Ser Leu Thr Lys Leu Ser
            20                  25                  30          
Leu Gln Asp Gly His Lys Ala Lys Lys Pro Ala Cys Lys Phe Glu Glu
        35                  40                  45              
Gly Gln Asp Val Leu Ala Arg Trp Ser Asp Gly Leu Phe Tyr Leu Gly
    50                  55                  60                  
Thr Ile Lys Lys Ile Asn Ile Leu Lys Gln Ser Cys Phe Ile Ile Phe
65                  70                  75                  80  
Glu Asp Ser Ser Lys Ser Trp Val Leu Trp Lys Asp Ile Gln Thr Gly
                85                  90                  95      
Ala Thr Gly Ser Gly Glu Met Val Cys Thr Ile Cys Gln Glu Glu Tyr
            100                 105                 110         
Ser Glu Ala Pro Asn Glu Met Val Ile Cys Asp Lys Cys Gly Gln Gly
        115                 120                 125             
Tyr His Gln Leu Cys His Thr Pro His Ile Asp Ser Ser Val Ile Asp
    130                 135                 140                 
Ser Asp Glu Lys Trp Leu Cys Arg Gln Cys Val Phe Ala Thr Thr Thr
145                 150                 155                 160 
Lys Arg Gly Gly Ala Leu Lys Lys Gly Pro Asn Ala Lys Ala Leu Gln
                165                 170                 175     
Val Met Lys Gln Thr Leu Pro Tyr Ser Val Ala Asp Leu Glu Trp Asp
            180                 185                 190         
Ala Gly His Lys Thr Asn Val Gln Gln Cys Tyr Cys Tyr Cys Gly Gly
        195                 200                 205             
Pro Gly Asp Trp Tyr Leu Lys Met Leu Gln Cys Cys Lys Cys Lys Gln
    210                 215                 220                 
Trp Phe His Glu Ala Cys Val Gln Cys Leu Gln Lys Pro Met Leu Phe
225                 230                 235                 240 
Gly Asp Arg Phe Tyr Thr Phe Ile Cys Ser Val Cys Ser Ser Gly Pro
                245                 250                 255     
Glu Tyr Leu Lys Arg Leu Pro Leu Gln Trp Val Asp Ile Ala His Leu
            260                 265                 270         
Cys Leu Tyr Asn Leu Ser Val Ile His Lys Lys Lys Tyr Phe Asp Ser
        275                 280                 285             
Glu Leu Glu Leu Met Thr Tyr Ile Asn Glu Asn Trp Asp Arg Leu His
    290                 295                 300                 
Pro Gly Glu Leu Ala Asp Thr Pro Lys Ser Glu Arg Tyr Glu His Val
305                 310                 315                 320 
Leu Glu Ala Leu Asn Asp Tyr Lys Thr Met Glu Val Ser Asn Gly Ile
                325                 330                 335     
Glu Lys Lys Gly Lys Lys Lys Ser Val Gly Arg Pro Pro Gly Pro Tyr
            340                 345                 350         
Thr Arg Lys Met Ile Gln Lys Thr Ala Glu Pro Leu Leu Asp Lys Glu
        355                 360                 365             
Ser Ile Ser Glu Asn Pro Thr Leu Asp Leu Pro Cys Ser Ile Gly Arg
    370                 375                 380                 
Thr Glu Gly Thr Ala His Ser Ser Asn Thr Ser Asp Val Asp Phe Thr
385                 390                 395                 400 
Gly Ala Ser Ser Ala Lys Glu Thr Thr Ser Ser Ser Ile Ser Arg His
                405                 410                 415     
Tyr Gly Leu Ser Asp Ser Arg Lys Arg Thr Arg Thr Gly Arg Ser Trp
            420                 425                 430         
Pro Ala Ala Ile Pro His Leu Arg Arg Arg Arg Gly Arg Leu Pro Arg
        435                 440                 445             
Arg Ala Leu Gln Thr Gln Asn Ser Glu Ile Val Lys Asp Asp Glu Gly
    450                 455                 460                 
Lys Glu Asp Tyr Gln Phe Asp Glu Leu Asn Thr Glu Ile Leu Asn Asn
465                 470                 475                 480 
Leu Ala Asp Gln Glu Leu Gln Leu Asn His Leu Lys Asn Ser Ile Thr
                485                 490                 495     
Ser Tyr Phe Gly Ala Ala Gly Arg Ile Ala Cys Gly Glu Lys Tyr Arg
            500                 505                 510         
Val Leu Ala Arg Arg Val Thr Leu Asp Gly Lys Val Gln Tyr Leu Val
        515                 520                 525             
Glu Trp Glu Gly Ala Thr Ala Ser
    530                 535     


<210> 1903
<211> 563
<212> PRT
<213> Homo sapiens

<400> 1903
Met Arg Pro Val Ser Arg Val Leu Ala Pro His Leu Thr Arg Ala Tyr
 1               5                  10                  15      
Ala Lys Asp Val Lys Phe Gly Ala Asp Ala Arg Ala Leu Met Leu Gln
            20                  25                  30          
Gly Val Asp Leu Leu Ala Asp Ala Val Ala Val Thr Met Gly Pro Lys
        35                  40                  45              
Gly Arg Thr Val Ile Ile Glu Gln Ser Trp Gly Ser Pro Lys Val Thr
    50                  55                  60                  
Lys Asp Gly Val Thr Val Ala Lys Ser Ile Asp Leu Lys Asp Lys Tyr
65                  70                  75                  80  
Lys Asn Ile Gly Ala Lys Leu Val Gln Asp Val Ala Asn Asn Thr Asn
                85                  90                  95      
Glu Glu Ala Gly Asp Gly Thr Thr Thr Ala Thr Val Leu Ala Arg Ser
            100                 105                 110         
Ile Ala Lys Glu Gly Phe Glu Lys Ile Ser Lys Gly Ala Asn Pro Val
        115                 120                 125             
Glu Ile Arg Arg Gly Val Met Leu Ala Val Asp Ala Val Ile Ala Glu
    130                 135                 140                 
Leu Lys Lys Gln Ser Lys Pro Val Thr Thr Pro Glu Glu Ile Ala Gln
145                 150                 155                 160 
Val Ala Thr Ile Ser Ala Asn Gly Asp Lys Glu Ile Gly Asn Ile Ile
                165                 170                 175     
Ser Asp Ala Met Lys Lys Val Gly Arg Lys Gly Val Ile Thr Val Lys
            180                 185                 190         
Asp Gly Lys Thr Leu Asn Asp Glu Leu Glu Ile Ile Glu Gly Met Lys
        195                 200                 205             
Phe Asp Arg Gly Tyr Ile Ser Pro Tyr Phe Ile Asn Thr Ser Lys Gly
    210                 215                 220                 
Gln Lys Cys Glu Phe Gln Asp Ala Tyr Val Leu Leu Ser Glu Lys Lys
225                 230                 235                 240 
Ile Ser Ser Ile Gln Ser Ile Val Pro Ala Leu Glu Ile Ala Asn Ala
                245                 250                 255     
His Arg Lys Pro Leu Val Ile Ile Ala Glu Asp Val Asp Gly Glu Ala
            260                 265                 270         
Leu Ser Thr Leu Val Leu Asn Arg Leu Lys Val Gly Leu Gln Val Val
        275                 280                 285             
Ala Val Lys Ala Pro Gly Phe Gly Asp Asn Arg Lys Asn Gln Leu Lys
    290                 295                 300                 
Asp Met Ala Ile Ala Thr Gly Gly Ala Val Phe Gly Glu Glu Gly Leu
305                 310                 315                 320 
Thr Leu Asn Leu Glu Asp Val Gln Pro His Asp Leu Gly Lys Val Gly
                325                 330                 335     
Glu Val Ile Val Thr Lys Asp Asp Ala Met Leu Leu Lys Gly Lys Gly
            340                 345                 350         
Asp Lys Ala Gln Ile Glu Lys Arg Ile Gln Glu Ile Ile Glu Gln Leu
        355                 360                 365             
Asp Val Thr Thr Ser Glu Tyr Glu Lys Glu Lys Leu Asn Glu Arg Leu
    370                 375                 380                 
Ala Lys Leu Ser Asp Gly Val Ala Val Leu Lys Val Gly Gly Thr Ser
385                 390                 395                 400 
Asp Val Glu Val Asn Glu Lys Lys Asp Arg Val Thr Asp Ala Leu Asn
                405                 410                 415     
Ala Thr Arg Ala Ala Val Glu Glu Gly Ile Val Leu Gly Gly Gly Cys
            420                 425                 430         
Ala Leu Leu Arg Cys Ile Pro Ala Leu Asp Ser Leu Thr Pro Ala Asn
        435                 440                 445             
Glu Asp Gln Lys Ile Gly Ile Glu Ile Ile Lys Arg Thr Leu Lys Ile
    450                 455                 460                 
Pro Ala Met Thr Ile Ala Lys Asn Ala Gly Val Glu Gly Ser Leu Ile
465                 470                 475                 480 
Val Glu Lys Ile Met Gln Ser Ser Ser Glu Val Gly Tyr Asp Ala Met
                485                 490                 495     
Ala Gly Asp Phe Val Asn Met Val Glu Lys Gly Ile Ile Asp Pro Thr
            500                 505                 510         
Lys Val Val Arg Thr Ala Leu Leu Asp Ala Ala Gly Val Ala Ser Leu
        515                 520                 525             
Leu Thr Thr Ala Glu Val Val Val Thr Glu Ile Pro Lys Glu Glu Lys
    530                 535                 540                 
Asp Pro Gly Met Gly Ala Met Gly Gly Met Gly Gly Gly Met Gly Gly
545                 550                 555                 560 
Gly Met Phe
            


<210> 1904
<211> 356
<212> PRT
<213> Homo sapiens

<400> 1904
Met Leu Ala Arg Ala Ala Arg Gly Thr Gly Ala Leu Leu Leu Arg Gly
 1               5                  10                  15      
Ser Leu Leu Ala Ser Gly Arg Ala Pro Arg Arg Ala Ser Ser Gly Leu
            20                  25                  30          
Pro Arg Asn Thr Val Val Leu Phe Val Pro Gln Gln Glu Ala Trp Val
        35                  40                  45              
Val Glu Arg Met Gly Arg Phe His Arg Ile Leu Glu Pro Gly Leu Asn
    50                  55                  60                  
Ile Leu Ile Pro Val Leu Asp Arg Ile Arg Tyr Val Gln Ser Leu Lys
65                  70                  75                  80  
Glu Ile Val Ile Asn Val Pro Glu Gln Ser Ala Val Thr Leu Asp Asn
                85                  90                  95      
Val Thr Leu Gln Ile Asp Gly Val Leu Tyr Leu Arg Ile Met Asp Pro
            100                 105                 110         
Tyr Lys Ala Ser Tyr Gly Val Glu Asp Pro Glu Tyr Ala Val Thr Gln
        115                 120                 125             
Pro Ala Gln Thr Thr Met Arg Ser Glu Leu Gly Lys Leu Ser Leu Asp
    130                 135                 140                 
Lys Val Phe Arg Glu Arg Glu Ser Leu Asn Ala Ser Ile Val Asp Ala
145                 150                 155                 160 
Ile Asn Gln Ala Ala Asp Cys Trp Gly Ile Arg Cys Leu Arg Tyr Glu
                165                 170                 175     
Ile Lys Asp Ile His Val Pro Pro Arg Val Lys Glu Ser Met Gln Met
            180                 185                 190         
Gln Val Glu Ala Glu Arg Arg Lys Arg Ala Thr Val Leu Glu Ser Glu
        195                 200                 205             
Gly Thr Arg Glu Ser Ala Ile Asn Val Ala Glu Gly Lys Lys Gln Ala
    210                 215                 220                 
Gln Ile Leu Ala Ser Glu Ala Glu Lys Ala Glu Gln Ile Asn Gln Ala
225                 230                 235                 240 
Ala Gly Glu Ala Ser Ala Val Leu Ala Lys Ala Lys Ala Lys Ala Glu
                245                 250                 255     
Ala Ile Arg Ile Leu Ala Ala Ala Leu Thr Gln His Asn Gly Asp Ala
            260                 265                 270         
Ala Ala Ser Leu Thr Val Ala Glu Gln Tyr Val Ser Ala Phe Ser Lys
        275                 280                 285             
Leu Ala Lys Asp Ser Asn Thr Ile Leu Leu Pro Ser Asn Pro Gly Asp
    290                 295                 300                 
Val Thr Ser Met Val Ala Gln Ala Met Gly Val Tyr Gly Ala Leu Thr
305                 310                 315                 320 
Lys Ala Pro Val Pro Gly Thr Pro Asp Ser Leu Ser Ser Gly Ser Ser
                325                 330                 335     
Arg Asp Val Gln Gly Thr Asp Ala Ser Leu Asp Glu Glu Leu Asp Arg
            340                 345                 350         
Val Lys Met Ser
        355     


<210> 1905
<211> 687
<212> PRT
<213> Homo sapiens

<400> 1905
Met Glu Arg Val Asn Asp Ala Ser Cys Gly Pro Ser Gly Cys Tyr Thr
 1               5                  10                  15      
Tyr Gln Val Ser Arg His Ser Thr Glu Met Leu His Asn Leu Asn Gln
            20                  25                  30          
Gln Arg Lys Asn Gly Gly Arg Phe Cys Asp Val Leu Leu Arg Val Gly
        35                  40                  45              
Asp Glu Ser Phe Pro Ala His Arg Ala Val Leu Ala Ala Cys Ser Glu
    50                  55                  60                  
Tyr Phe Glu Ser Val Phe Ser Ala Gln Leu Gly Asp Gly Gly Ala Ala
65                  70                  75                  80  
Asp Gly Gly Pro Ala Asp Val Gly Gly Ala Thr Ala Ala Pro Gly Gly
                85                  90                  95      
Gly Ala Gly Gly Ser Arg Glu Leu Glu Met His Thr Ile Ser Ser Lys
            100                 105                 110         
Val Phe Gly Asp Ile Leu Asp Phe Ala Tyr Thr Ser Arg Ile Val Val
        115                 120                 125             
Arg Leu Glu Ser Phe Pro Glu Leu Met Thr Ala Ala Lys Phe Leu Leu
    130                 135                 140                 
Met Arg Ser Val Ile Glu Ile Cys Gln Glu Val Ile Lys Gln Ser Asn
145                 150                 155                 160 
Val Gln Ile Leu Val Pro Pro Ala Arg Ala Asp Ile Met Leu Phe Arg
                165                 170                 175     
Pro Pro Gly Thr Ser Asp Leu Gly Phe Pro Leu Asp Met Thr Asn Gly
            180                 185                 190         
Ala Ala Leu Ala Ala Asn Ser Asn Gly Ile Ala Gly Ser Met Gln Pro
        195                 200                 205             
Glu Glu Glu Ala Ala Arg Ala Ala Gly Ala Ala Ile Ala Gly Gln Ala
    210                 215                 220                 
Ser Leu Pro Val Leu Pro Gly Val Asp Arg Leu Pro Met Val Ala Gly
225                 230                 235                 240 
Pro Leu Ser Pro Gln Leu Leu Thr Ser Pro Phe Pro Ser Val Ala Ser
                245                 250                 255     
Ser Ala Pro Pro Leu Thr Gly Lys Arg Gly Arg Gly Arg Pro Arg Lys
            260                 265                 270         
Ala Asn Leu Leu Asp Ser Met Phe Gly Ser Pro Gly Gly Leu Arg Glu
        275                 280                 285             
Ala Gly Ile Leu Pro Cys Gly Leu Cys Gly Lys Val Phe Thr Asp Ala
    290                 295                 300                 
Asn Arg Leu Arg Gln His Glu Ala Gln His Gly Val Thr Ser Leu Gln
305                 310                 315                 320 
Leu Gly Tyr Ile Asp Leu Pro Pro Pro Arg Leu Gly Glu Asn Gly Leu
                325                 330                 335     
Pro Ile Ser Glu Asp Pro Asp Gly Pro Arg Lys Arg Ser Arg Thr Arg
            340                 345                 350         
Lys Gln Val Ala Cys Glu Ile Cys Gly Lys Ile Phe Arg Asp Val Tyr
        355                 360                 365             
His Leu Asn Arg His Lys Leu Ser His Ser Gly Glu Lys Pro Tyr Ser
    370                 375                 380                 
Cys Pro Val Cys Gly Leu Arg Phe Lys Arg Lys Asp Arg Met Ser Tyr
385                 390                 395                 400 
His Val Arg Ser His Asp Gly Ser Val Gly Lys Pro Tyr Ile Cys Gln
                405                 410                 415     
Ser Cys Gly Lys Gly Phe Ser Arg Pro Asp His Leu Asn Gly His Ile
            420                 425                 430         
Lys Gln Val His Thr Ser Glu Arg Pro His Lys Cys Gln Thr Cys Asn
        435                 440                 445             
Ala Ser Phe Ala Thr Arg Asp Arg Leu Arg Ser His Leu Ala Cys His
    450                 455                 460                 
Glu Asp Lys Val Pro Cys Gln Val Cys Gly Lys Tyr Leu Arg Ala Ala
465                 470                 475                 480 
Tyr Met Ala Asp His Leu Lys Lys His Ser Glu Gly Pro Ser Asn Phe
                485                 490                 495     
Cys Ser Ile Cys Asn Arg Gly Phe Ser Ser Ala Ser Tyr Leu Lys Val
            500                 505                 510         
His Val Lys Thr His His Gly Val Pro Leu Pro Gln Val Ser Arg His
        515                 520                 525             
Gln Glu Pro Ile Leu Asn Gly Gly Ala Ala Phe His Cys Ala Arg Thr
    530                 535                 540                 
Tyr Gly Asn Lys Glu Gly Gln Lys Cys Ser His Gln Asp Pro Ile Glu
545                 550                 555                 560 
Ser Ser Asp Ser Tyr Gly Asp Leu Ser Asp Ala Ser Asp Leu Lys Thr
                565                 570                 575     
Pro Glu Lys Gln Ser Ala Asn Gly Ser Phe Ser Cys Asp Met Ala Val
            580                 585                 590         
Pro Lys Asn Lys Met Glu Ser Asp Gly Glu Lys Lys Tyr Pro Cys Pro
        595                 600                 605             
Glu Cys Gly Ser Phe Phe Arg Ser Lys Ser Tyr Leu Asn Lys His Ile
    610                 615                 620                 
Gln Lys Val His Val Arg Ala Leu Gly Gly Pro Leu Gly Asp Leu Gly
625                 630                 635                 640 
Pro Ala Leu Gly Ser Pro Phe Ser Pro Gln Gln Asn Met Ser Leu Leu
                645                 650                 655     
Glu Ser Phe Gly Phe Gln Ile Val Gln Ser Ala Phe Ala Ser Ser Leu
            660                 665                 670         
Val Asp Pro Glu Val Asp Gln Gln Pro Met Gly Pro Glu Gly Lys
        675                 680                 685         


<210> 1906
<211> 387
<212> PRT
<213> Homo sapiens

<400> 1906
Met Asp Met Asn Ser Phe Ser Pro Met Met Pro Thr Ser Pro Leu Ser
 1               5                  10                  15      
Met Ile Asn Gln Ile Lys Phe Glu Asp Glu Pro Asp Leu Lys Asp Leu
            20                  25                  30          
Phe Ile Thr Val Asp Glu Pro Glu Ser His Val Thr Thr Ile Glu Thr
        35                  40                  45              
Phe Ile Thr Tyr Arg Ile Ile Thr Lys Thr Ser Arg Gly Glu Phe Asp
    50                  55                  60                  
Ser Ser Glu Phe Glu Val Arg Arg Arg Tyr Gln Asp Phe Leu Trp Leu
65                  70                  75                  80  
Lys Gly Lys Leu Glu Glu Ala His Pro Thr Leu Ile Ile Pro Pro Leu
                85                  90                  95      
Pro Glu Lys Phe Ile Val Lys Gly Met Val Glu Arg Phe Asn Asp Asp
            100                 105                 110         
Phe Ile Glu Thr Arg Arg Lys Ala Leu His Lys Phe Leu Asn Arg Ile
        115                 120                 125             
Ala Asp His Pro Thr Leu Thr Phe Asn Glu Asp Phe Lys Ile Phe Leu
    130                 135                 140                 
Thr Ala Gln Ala Trp Glu Leu Ser Pro His Lys Lys Gln Gly Pro Gly
145                 150                 155                 160 
Leu Leu Ser Arg Met Gly Gln Thr Val Arg Ala Val Ala Ser Ser Met
                165                 170                 175     
Arg Gly Val Lys Asn Arg Pro Glu Glu Phe Met Glu Met Asn Asn Phe
            180                 185                 190         
Ile Glu Leu Phe Ser Gln Lys Ile Asn Leu Ile Asp Lys Ile Ser Gln
        195                 200                 205             
Arg Ile Tyr Lys Glu Glu Arg Glu Tyr Phe Asp Glu Met Lys Glu Tyr
    210                 215                 220                 
Gly Pro Ile His Ile Leu Trp Ser Ala Ser Glu Glu Asp Leu Val Asp
225                 230                 235                 240 
Thr Leu Lys Asp Val Ala Ser Cys Ile Asp Arg Cys Cys Lys Ala Thr
                245                 250                 255     
Glu Lys Arg Met Ser Gly Leu Ser Glu Ala Leu Leu Pro Val Val His
            260                 265                 270         
Glu Tyr Val Leu Tyr Ser Glu Met Leu Met Gly Val Met Lys Arg Arg
        275                 280                 285             
Asp Gln Ile Gln Ala Glu Leu Asp Ser Lys Val Glu Val Leu Thr Tyr
    290                 295                 300                 
Lys Lys Ala Asp Thr Asp Leu Leu Pro Glu Glu Ile Gly Lys Leu Glu
305                 310                 315                 320 
Asp Lys Val Glu Cys Ala Asn Asn Ala Leu Lys Ala Asp Trp Glu Arg
                325                 330                 335     
Trp Lys Gln Asn Met Gln Asn Asp Ile Lys Leu Ala Phe Thr Asp Met
            340                 345                 350         
Ala Glu Glu Asn Ile His Tyr Tyr Glu Gln Cys Leu Ala Thr Trp Glu
        355                 360                 365             
Ser Phe Leu Thr Ser Gln Thr Asn Leu His Leu Glu Glu Ala Ser Glu
    370                 375                 380                 
Asp Lys Pro
385         


<210> 1907
<211> 501
<212> PRT
<213> Homo sapiens

<400> 1907
Met Ala Ala Ser Trp Arg Leu Gly Cys Asp Pro Arg Leu Leu Arg Tyr
 1               5                  10                  15      
Leu Val Gly Phe Pro Gly Arg Arg Ser Val Gly Leu Val Lys Gly Ala
            20                  25                  30          
Leu Gly Trp Ser Val Ser Arg Gly Ala Asn Trp Arg Trp Phe His Ser
        35                  40                  45              
Thr Gln Trp Leu Arg Gly Asp Pro Ile Lys Ile Leu Met Pro Ser Leu
    50                  55                  60                  
Ser Pro Thr Met Glu Glu Gly Asn Ile Val Lys Trp Leu Lys Lys Glu
65                  70                  75                  80  
Gly Glu Ala Val Ser Ala Gly Asp Ala Leu Cys Glu Ile Glu Thr Asp
                85                  90                  95      
Lys Ala Val Val Thr Leu Asp Ala Ser Asp Asp Gly Ile Leu Ala Lys
            100                 105                 110         
Ile Val Val Glu Glu Gly Ser Lys Asn Ile Arg Leu Gly Ser Leu Ile
        115                 120                 125             
Gly Leu Ile Val Glu Glu Gly Glu Asp Trp Lys His Val Glu Ile Pro
    130                 135                 140                 
Lys Asp Val Gly Pro Pro Pro Pro Val Ser Lys Pro Ser Glu Pro Arg
145                 150                 155                 160 
Pro Ser Pro Glu Pro Gln Ile Ser Ile Pro Val Lys Lys Glu His Ile
                165                 170                 175     
Pro Gly Thr Leu Arg Phe Arg Leu Ser Pro Ala Ala Arg Asn Ile Leu
            180                 185                 190         
Glu Lys His Ser Leu Asp Ala Ser Gln Gly Thr Ala Thr Gly Pro Arg
        195                 200                 205             
Gly Ile Phe Thr Lys Glu Asp Ala Leu Lys Leu Val Gln Leu Lys Gln
    210                 215                 220                 
Thr Gly Lys Ile Thr Glu Ser Arg Pro Thr Pro Ala Pro Thr Ala Thr
225                 230                 235                 240 
Pro Thr Ala Pro Ser Pro Leu Gln Ala Thr Ala Gly Pro Ser Tyr Pro
                245                 250                 255     
Arg Pro Val Ile Pro Pro Val Ser Thr Pro Gly Gln Pro Asn Ala Val
            260                 265                 270         
Gly Thr Phe Thr Glu Ile Pro Ala Ser Asn Ile Arg Arg Val Ile Ala
        275                 280                 285             
Lys Arg Leu Thr Glu Ser Lys Ser Thr Val Pro His Ala Tyr Ala Thr
    290                 295                 300                 
Ala Asp Cys Asp Leu Gly Ala Val Leu Lys Val Arg Gln Asp Leu Val
305                 310                 315                 320 
Lys Asp Asp Ile Lys Val Ser Val Asn Asp Phe Ile Ile Lys Ala Ala
                325                 330                 335     
Ala Val Thr Leu Lys Gln Met Pro Asp Val Asn Val Ser Trp Asp Gly
            340                 345                 350         
Glu Gly Pro Lys Gln Leu Pro Phe Ile Asp Ile Ser Val Ala Val Ala
        355                 360                 365             
Thr Val Lys Gly Leu Leu Thr Pro Ile Ile Lys Asp Ala Ala Ala Lys
    370                 375                 380                 
Gly Ile Gln Glu Ile Ala Asp Ser Val Lys Ala Leu Ser Lys Lys Ala
385                 390                 395                 400 
Arg Asp Gly Lys Leu Leu Pro Glu Glu Tyr Gln Gly Gly Ser Phe Ser
                405                 410                 415     
Ile Ser Asn Leu Gly Met Phe Gly Ile Asp Glu Phe Thr Ala Val Ile
            420                 425                 430         
Asn Pro Pro Gln Ala Cys Ile Leu Ala Val Gly Arg Phe Arg Pro Val
        435                 440                 445             
Leu Lys Leu Thr Glu Asp Glu Glu Gly Asn Ala Lys Leu Gln Gln Arg
    450                 455                 460                 
Gln Leu Ile Thr Val Thr Met Ser Ser Asp Ser Arg Val Val Asp Asp
465                 470                 475                 480 
Glu Leu Ala Thr Arg Phe Leu Lys Ser Phe Lys Ala Asn Leu Glu Asn
                485                 490                 495     
Pro Ile Arg Leu Ala
            500     


<210> 1908
<211> 490
<212> PRT
<213> Homo sapiens

<400> 1908
Met Ala Ala Ala Ala Ala Arg Val Val Leu Ser Ser Ala Ala Arg Arg
 1               5                  10                  15      
Arg Leu Trp Gly Phe Ser Glu Ser Leu Leu Ile Arg Gly Ala Ala Gly
            20                  25                  30          
Arg Ser Leu Tyr Phe Gly Glu Asn Arg Leu Arg Ser Thr Gln Ala Ala
        35                  40                  45              
Thr Gln Val Val Leu Asn Val Pro Glu Thr Arg Val Thr Cys Leu Glu
    50                  55                  60                  
Ser Gly Leu Arg Val Ala Ser Glu Asp Ser Gly Leu Ser Thr Cys Thr
65                  70                  75                  80  
Val Gly Leu Trp Ile Asp Ala Gly Ser Arg Tyr Glu Asn Glu Lys Asn
                85                  90                  95      
Asn Gly Thr Ala His Phe Leu Glu His Met Ala Phe Lys Gly Thr Lys
            100                 105                 110         
Lys Arg Ser Gln Leu Asp Leu Glu Leu Glu Ile Glu Asn Met Gly Ala
        115                 120                 125             
His Leu Asn Ala Tyr Thr Ser Arg Glu Gln Thr Val Tyr Tyr Ala Lys
    130                 135                 140                 
Ala Phe Ser Lys Asp Leu Pro Arg Ala Val Glu Ile Leu Ala Asp Ile
145                 150                 155                 160 
Ile Gln Asn Ser Thr Leu Gly Glu Ala Glu Ile Glu Arg Glu Arg Gly
                165                 170                 175     
Val Ile Leu Arg Glu Met Gln Glu Val Glu Thr Asn Leu Gln Glu Val
            180                 185                 190         
Val Phe Asp Tyr Leu His Ala Thr Ala Tyr Gln Asn Thr Ala Leu Gly
        195                 200                 205             
Arg Thr Ile Leu Gly Pro Thr Glu Asn Ile Lys Ser Ile Ser Arg Lys
    210                 215                 220                 
Asp Leu Val Asp Tyr Ile Thr Thr His Tyr Lys Gly Pro Arg Ile Val
225                 230                 235                 240 
Leu Ala Ala Ala Gly Gly Val Ser His Asp Glu Leu Leu Asp Leu Ala
                245                 250                 255     
Lys Phe His Phe Gly Asp Ser Leu Cys Thr His Lys Gly Glu Ile Pro
            260                 265                 270         
Ala Leu Pro Pro Cys Lys Phe Thr Gly Ser Glu Ile Arg Val Arg Asp
        275                 280                 285             
Asp Lys Met Pro Leu Ala His Leu Ala Ile Ala Val Glu Ala Val Gly
    290                 295                 300                 
Trp Ala His Pro Asp Thr Ile Cys Leu Met Val Ala Asn Thr Leu Ile
305                 310                 315                 320 
Gly Asn Trp Asp Arg Ser Phe Gly Gly Gly Met Asn Leu Ser Ser Lys
                325                 330                 335     
Leu Ala Gln Leu Thr Cys His Gly Asn Leu Cys His Ser Phe Gln Ser
            340                 345                 350         
Phe Asn Thr Ser Tyr Thr Asp Thr Gly Leu Trp Gly Leu Tyr Met Val
        355                 360                 365             
Cys Glu Ser Ser Thr Val Ala Asp Met Leu His Val Val Gln Lys Glu
    370                 375                 380                 
Trp Met Arg Leu Cys Thr Ser Val Thr Glu Ser Glu Val Ala Arg Ala
385                 390                 395                 400 
Arg Asn Leu Leu Lys Thr Asn Met Leu Leu Gln Leu Asp Gly Ser Thr
                405                 410                 415     
Pro Ile Cys Glu Asp Ile Gly Arg Gln Met Leu Cys Tyr Asn Arg Arg
            420                 425                 430         
Ile Pro Ile Pro Glu Leu Glu Ala Arg Ile Asp Ala Val Asn Ala Glu
        435                 440                 445             
Thr Ile Arg Glu Val Cys Thr Lys Tyr Ile Tyr Asn Arg Ser Pro Ala
    450                 455                 460                 
Ile Ala Ala Val Gly Lys Pro Gly Phe Phe Ser Ser Met Gln Lys Val
465                 470                 475                 480 
Gly Gln Val Leu Leu Ile Asn Ser Ser Phe
                485                 490 


<210> 1909
<211> 759
<212> PRT
<213> Homo sapiens

<400> 1909
Thr Leu Ala Ala Gly Ser Ile Ser Met Ala Glu Val Met Gln His Pro
 1               5                  10                  15      
Ser Glu Gly Gly Gln Val Leu Ser Leu Cys Ser Ser Ile Lys Glu Ala
            20                  25                  30          
Pro Val Lys Ala Ala Glu Ile Trp Ile Ala Ser Leu Ser Ser Gln Pro
        35                  40                  45              
Ile Asp His Glu Asp Ser Thr Met Gln Ala Gly Pro Lys Ala Lys Ser
    50                  55                  60                  
Thr Asp Asn Tyr Ser Glu Glu Glu Tyr Glu Ser Phe Ser Ser Glu Gln
65                  70                  75                  80  
Glu Ala Ser Asp Asp Ala Val Gln Gly Gln Asp Leu Asp Glu Asp Asp
                85                  90                  95      
Phe Asp Val Gly Lys Pro Lys Lys Gln Arg Arg Ser Ile Val Arg Thr
            100                 105                 110         
Thr Ser Met Thr Arg Gln Gln Asn Phe Lys Gln Lys Val Val Ala Leu
        115                 120                 125             
Leu Arg Arg Phe Lys Val Ser Asp Glu Val Leu Asp Ser Glu Gln Asp
    130                 135                 140                 
Pro Ala Glu His Ile Pro Glu Ala Glu Glu Asp Leu Asp Leu Leu Tyr
145                 150                 155                 160 
Asp Thr Leu Asp Met Glu His Pro Ser Asp Ser Gly Pro Asp Met Glu
                165                 170                 175     
Asp Asp Asp Ser Val Leu Ser Thr Pro Lys Pro Lys Leu Arg Pro Tyr
            180                 185                 190         
Phe Glu Gly Leu Ser His Ser Ser Ser Gln Thr Glu Ile Gly Ser Ile
        195                 200                 205             
His Ser Ala Arg Ser His Lys Glu Pro Pro Ser Pro Ala Asp Val Pro
    210                 215                 220                 
Glu Lys Thr Arg Ser Leu Gly Gly Arg Gln Pro Ser Asp Ser Val Ser
225                 230                 235                 240 
Asp Thr Val Ala Leu Gly Val Pro Gly Pro Arg Glu His Pro Gly Gln
                245                 250                 255     
Pro Glu Asp Ser Pro Glu Ala Glu Ala Ser Thr Leu Asp Val Phe Thr
            260                 265                 270         
Glu Arg Leu Pro Pro Ser Gly Arg Ile Thr Lys Thr Glu Ser Leu Val
        275                 280                 285             
Ile Pro Ser Thr Arg Ser Glu Gly Lys Gln Ala Gly Arg Arg Gly Arg
    290                 295                 300                 
Ser Thr Ser Leu Lys Glu Arg Gln Ala Ala Arg Pro Gln Asn Glu Arg
305                 310                 315                 320 
Ala Asn Ser Leu Asp Asn Glu Arg Cys Pro Asp Ala Arg Ser Gln Leu
                325                 330                 335     
Gln Ile Pro Arg Lys Thr Val Tyr Asp Gln Leu Asn His Ile Leu Ile
            340                 345                 350         
Ser Asp Asp Gln Leu Pro Glu Asn Ile Ile Leu Val Asn Thr Ser Asp
        355                 360                 365             
Trp Gln Gly Gln Phe Leu Ser Asp Val Leu Gln Arg His Thr Leu Pro
    370                 375                 380                 
Val Val Cys Thr Cys Ser Pro Ala Asp Val Gln Ala Ala Phe Ser Thr
385                 390                 395                 400 
Ile Val Ser Arg Ile Gln Arg Tyr Cys Asn Cys Asn Ser Gln Pro Pro
                405                 410                 415     
Thr Pro Val Lys Ile Ala Val Ala Gly Ala Gln His Tyr Leu Ser Ala
            420                 425                 430         
Ile Leu Arg Leu Phe Val Glu Gln Leu Ser His Lys Thr Pro Asp Trp
        435                 440                 445             
Leu Gly Tyr Met Arg Phe Leu Val Ile Pro Leu Gly Ser His Pro Val
    450                 455                 460                 
Ala Arg Tyr Leu Gly Ser Val Asp Tyr Arg Tyr Asn Asn Phe Phe Gln
465                 470                 475                 480 
Asp Leu Ala Trp Arg Asp Leu Phe Asn Lys Leu Glu Ala Gln Ser Ala
                485                 490                 495     
Val Gln Asp Thr Pro Asp Ile Val Ser Arg Ile Thr Gln Tyr Ile Ala
            500                 505                 510         
Gly Ala Asn Cys Ala His Gln Leu Pro Ile Ala Glu Ala Met Leu Thr
        515                 520                 525             
Tyr Lys Gln Lys Ser Pro Asp Glu Glu Ser Ser Gln Lys Phe Ile Pro
    530                 535                 540                 
Phe Val Gly Val Val Lys Val Gly Ile Val Glu Pro Ser Ser Ala Thr
545                 550                 555                 560 
Ser Gly Asp Ser Asp Asp Ala Ala Pro Ser Gly Ser Gly Thr Leu Ser
                565                 570                 575     
Ser Thr Pro Pro Ser Ala Ser Pro Ala Ala Lys Glu Ala Ser Pro Thr
            580                 585                 590         
Pro Pro Ser Ser Pro Ser Val Ser Gly Gly Leu Ser Ser Pro Ser Gln
        595                 600                 605             
Gly Val Gly Ala Glu Leu Met Gly Leu Gln Val Asp Tyr Trp Thr Ala
    610                 615                 620                 
Ala Gln Pro Ala Asp Arg Lys Arg Asp Ala Glu Lys Lys Asp Leu Pro
625                 630                 635                 640 
Val Thr Lys Asn Thr Leu Lys Cys Thr Phe Arg Ser Leu Gln Val Ser
                645                 650                 655     
Arg Leu Pro Ser Ser Gly Glu Ala Ala Ala Thr Pro Thr Met Ser Met
            660                 665                 670         
Thr Val Val Thr Lys Glu Lys Asn Lys Lys Val Met Phe Leu Pro Lys
        675                 680                 685             
Lys Ala Lys Asp Lys Asp Val Glu Ser Lys Ser Gln Cys Ile Glu Gly
    690                 695                 700                 
Ile Ser Arg Leu Ile Cys Thr Ala Arg Gln Gln Gln Asn Met Leu Arg
705                 710                 715                 720 
Val Leu Ile Asp Gly Val Glu Cys Ser Asp Val Lys Phe Phe Gln Leu
                725                 730                 735     
Ala Ala Gln Trp Ser Ser His Val Lys His Phe Pro Ile Cys Ile Phe
            740                 745                 750         
Gly His Ser Lys Ala Thr Phe
        755                 


<210> 1910
<211> 166
<212> PRT
<213> Homo sapiens

<400> 1910
Met Ala Ser Gly Val Thr Val Asn Asp Glu Val Ile Lys Val Phe Asn
 1               5                  10                  15      
Asp Met Lys Val Arg Lys Ser Ser Thr Gln Glu Glu Ile Lys Lys Arg
            20                  25                  30          
Lys Lys Ala Val Leu Phe Cys Leu Ser Asp Asp Lys Arg Gln Ile Ile
        35                  40                  45              
Val Glu Glu Ala Lys Gln Ile Leu Val Gly Asp Ile Gly Asp Thr Val
    50                  55                  60                  
Glu Asp Pro Tyr Thr Ser Phe Val Lys Leu Leu Pro Leu Asn Asp Cys
65                  70                  75                  80  
Arg Tyr Ala Leu Tyr Asp Ala Thr Tyr Glu Thr Lys Glu Ser Lys Lys
                85                  90                  95      
Glu Asp Leu Val Phe Ile Phe Trp Ala Pro Glu Ser Ala Pro Leu Lys
            100                 105                 110         
Ser Lys Met Ile Tyr Ala Ser Ser Lys Asp Ala Ile Lys Lys Lys Phe
        115                 120                 125             
Thr Gly Ile Lys His Glu Trp Gln Val Asn Gly Leu Asp Asp Ile Lys
    130                 135                 140                 
Asp Arg Ser Thr Leu Gly Glu Lys Leu Gly Gly Asn Val Val Val Ser
145                 150                 155                 160 
Leu Glu Gly Lys Pro Leu
                165     


<210> 1911
<211> 559
<212> PRT
<213> Homo sapiens

<400> 1911
Met Ala Thr Ala Leu Ser Glu Glu Glu Leu Asp Asn Glu Asp Tyr Tyr
 1               5                  10                  15      
Ser Leu Leu Asn Val Arg Arg Glu Ala Ser Ser Glu Glu Leu Lys Ala
            20                  25                  30          
Ala Tyr Arg Arg Leu Cys Met Leu Tyr His Pro Asp Lys His Arg Asp
        35                  40                  45              
Pro Glu Leu Lys Ser Gln Ala Glu Arg Leu Phe Asn Leu Val His Gln
    50                  55                  60                  
Ala Tyr Glu Val Leu Ser Asp Pro Gln Thr Arg Ala Ile Tyr Asp Ile
65                  70                  75                  80  
Tyr Gly Lys Arg Gly Leu Glu Met Glu Gly Trp Glu Val Val Glu Arg
                85                  90                  95      
Arg Arg Thr Pro Ala Glu Ile Arg Glu Glu Phe Glu Arg Leu Gln Arg
            100                 105                 110         
Glu Arg Glu Glu Arg Arg Leu Gln Gln Arg Thr Asn Pro Lys Gly Thr
        115                 120                 125             
Ile Ser Val Gly Val Asp Ala Thr Asp Leu Phe Asp Arg Tyr Asp Glu
    130                 135                 140                 
Glu Tyr Glu Asp Val Ser Gly Ser Ser Phe Pro Gln Ile Glu Ile Asn
145                 150                 155                 160 
Lys Met His Ile Ser Gln Ser Ile Glu Ala Pro Leu Thr Ala Thr Asp
                165                 170                 175     
Thr Ala Ile Leu Ser Gly Ser Leu Ser Thr Gln Asn Gly Asn Gly Gly
            180                 185                 190         
Gly Ser Ile Asn Phe Ala Leu Arg Arg Val Thr Ser Ala Lys Gly Trp
        195                 200                 205             
Gly Glu Leu Glu Phe Gly Ala Gly Asp Leu Gln Gly Pro Leu Phe Gly
    210                 215                 220                 
Leu Lys Leu Phe Arg Asn Leu Thr Pro Arg Cys Phe Val Thr Thr Asn
225                 230                 235                 240 
Cys Ala Leu Gln Phe Ser Ser Arg Gly Ile Arg Pro Gly Leu Thr Thr
                245                 250                 255     
Val Leu Ala Arg Asn Leu Asp Lys Asn Thr Val Gly Tyr Leu Gln Trp
            260                 265                 270         
Arg Trp Gly Ile Gln Ser Ala Met Asn Thr Ser Ile Val Arg Asp Thr
        275                 280                 285             
Lys Thr Ser His Phe Thr Val Ala Leu Gln Leu Gly Ile Pro His Ser
    290                 295                 300                 
Phe Ala Leu Ile Ser Tyr Gln His Lys Phe Gln Asp Asp Asp Gln Thr
305                 310                 315                 320 
Arg Val Lys Gly Ser Leu Lys Ala Gly Phe Phe Gly Thr Val Val Glu
                325                 330                 335     
Tyr Gly Ala Glu Arg Lys Ile Ser Arg His Ser Val Leu Gly Ala Ala
            340                 345                 350         
Val Ser Val Gly Val Pro Gln Gly Val Ser Leu Lys Val Lys Leu Asn
        355                 360                 365             
Arg Ala Ser Gln Thr Tyr Phe Phe Pro Ile His Leu Thr Asp Gln Leu
    370                 375                 380                 
Leu Pro Ser Ala Met Phe Tyr Ala Thr Val Gly Pro Leu Val Val Tyr
385                 390                 395                 400 
Phe Ala Met His Arg Leu Ile Ile Lys Pro Tyr Leu Arg Ala Gln Lys
                405                 410                 415     
Glu Lys Glu Leu Glu Lys Gln Arg Glu Ser Ala Ala Thr Asp Val Leu
            420                 425                 430         
Gln Lys Lys Gln Glu Ala Glu Ser Ala Val Arg Leu Met Gln Glu Ser
        435                 440                 445             
Val Arg Arg Ile Ile Glu Ala Glu Glu Ser Arg Met Gly Leu Ile Ile
    450                 455                 460                 
Val Asn Ala Trp Tyr Gly Lys Phe Val Asn Asp Lys Ser Arg Lys Ser
465                 470                 475                 480 
Glu Lys Val Lys Val Ile Asp Val Thr Val Pro Leu Gln Cys Leu Val
                485                 490                 495     
Lys Asp Ser Lys Leu Ile Leu Thr Glu Ala Ser Lys Ala Gly Leu Pro
            500                 505                 510         
Gly Phe Tyr Asp Pro Cys Val Gly Glu Glu Lys Asn Leu Lys Val Leu
        515                 520                 525             
Tyr Gln Phe Arg Gly Val Leu His Gln Val Met Val Leu Asp Ser Glu
    530                 535                 540                 
Ala Leu Arg Ile Pro Lys Gln Ser His Arg Ile Asp Thr Asp Gly
545                 550                 555                 


<210> 1912
<211> 109
<212> PRT
<213> Homo sapiens

<400> 1912
Met Val Trp Asn Thr Asp Leu Val Glu Thr Leu Glu Leu Gln Asn Leu
 1               5                  10                  15      
Met Leu Cys Ala Leu Gln Thr Val Asn Gly Ala Glu Ala Gly Lys Glu
            20                  25                  30          
Ser Arg Gly Ala His Ala Gly Glu Asp Tyr Lys Val Arg Ile Asp Glu
        35                  40                  45              
Tyr Asp His Ser Lys Pro Ile Gln Gly Gln Gln Lys Lys Pro Phe Glu
    50                  55                  60                  
Glu His Trp Arg Lys His Thr Leu Ser Tyr Val Asp Val Ser Thr Gly
65                  70                  75                  80  
Lys Val Thr Val Glu Tyr Arg Pro Ile Ile Asp Lys Thr Leu Asn Glu
                85                  90                  95      
Ala Asp Cys Ala Thr Val Pro Pro Ala Ile His Ser Tyr
            100                 105                 


<210> 1913
<211> 304
<212> PRT
<213> Homo sapiens

<400> 1913
Met Ala Pro Arg Arg Val Arg Ser Phe Leu Arg Gly Leu Pro Ala Leu
 1               5                  10                  15      
Leu Leu Leu Leu Leu Phe Leu Gly Pro Trp Pro Ala Ala Ser His Gly
            20                  25                  30          
Gly Lys Tyr Ser Arg Glu Lys Asn Gln Pro Lys Pro Ser Pro Lys Arg
        35                  40                  45              
Glu Ser Gly Glu Glu Phe Arg Met Glu Lys Leu Asn Gln Leu Trp Glu
    50                  55                  60                  
Lys Ala Gln Arg Leu His Leu Pro Pro Val Arg Leu Ala Glu Leu His
65                  70                  75                  80  
Ala Asp Leu Lys Ile Gln Glu Arg Asp Glu Leu Ala Trp Lys Lys Leu
                85                  90                  95      
Lys Leu Asp Gly Leu Asp Glu Asp Gly Glu Lys Glu Ala Arg Leu Ile
            100                 105                 110         
Arg Asn Leu Asn Val Ile Leu Ala Lys Tyr Gly Leu Asp Gly Lys Lys
        115                 120                 125             
Asp Ala Arg Gln Val Thr Ser Asn Ser Leu Ser Gly Thr Gln Glu Asp
    130                 135                 140                 
Gly Leu Asp Asp Pro Arg Leu Glu Lys Leu Trp His Lys Ala Lys Thr
145                 150                 155                 160 
Ser Gly Lys Phe Ser Gly Glu Glu Leu Asp Lys Leu Trp Arg Glu Phe
                165                 170                 175     
Leu His His Lys Glu Lys Val His Glu Tyr Asn Val Leu Leu Glu Thr
            180                 185                 190         
Leu Ser Arg Thr Glu Glu Ile His Glu Asn Val Ile Ser Pro Ser Asp
        195                 200                 205             
Leu Ser Asp Ile Lys Gly Ser Val Leu His Ser Arg His Thr Glu Leu
    210                 215                 220                 
Lys Glu Lys Leu Arg Ser Ile Asn Gln Gly Leu Asp Arg Leu Arg Arg
225                 230                 235                 240 
Val Ser His Gln Gly Tyr Ser Thr Glu Ala Glu Phe Glu Glu Pro Arg
                245                 250                 255     
Val Ile Asp Leu Trp Asp Leu Ala Gln Ser Ala Asn Ser Arg Thr Arg
            260                 265                 270         
Ser Trp Arg Arg Ser Gly Arg Ser Ser Ser Thr Ser Lys Pro Lys Ser
        275                 280                 285             
Arg Ser Thr Thr Thr Thr Arg Ser Ser Trp Arg Leu Arg Thr Arg Ser
    290                 295                 300                 


<210> 1914
<211> 571
<212> PRT
<213> Homo sapiens

<400> 1914
Met Asp Arg Ser Lys Arg Asn Ser Ile Ala Gly Phe Pro Pro Arg Val
 1               5                  10                  15      
Glu Arg Leu Glu Glu Phe Glu Gly Gly Gly Gly Gly Glu Gly Asn Val
            20                  25                  30          
Ser Gln Val Gly Arg Val Trp Pro Ser Ser Tyr Arg Ala Leu Ile Ser
        35                  40                  45              
Ala Phe Ser Arg Leu Thr Arg Leu Asp Asp Phe Thr Cys Glu Lys Ile
    50                  55                  60                  
Gly Ser Gly Phe Phe Ser Glu Val Phe Lys Val Arg His Arg Ala Ser
65                  70                  75                  80  
Gly Gln Val Met Ala Leu Lys Met Asn Thr Leu Ser Ser Asn Arg Ala
                85                  90                  95      
Asn Met Leu Lys Glu Val Gln Leu Met Asn Arg Leu Ser His Pro Asn
            100                 105                 110         
Ile Leu Arg Phe Met Gly Val Cys Val His Gln Gly Gln Leu His Ala
        115                 120                 125             
Leu Thr Glu Tyr Ile Asn Ser Gly Asn Leu Glu Gln Leu Leu Asp Ser
    130                 135                 140                 
Asn Leu His Leu Pro Trp Thr Val Arg Val Lys Leu Ala Tyr Asp Ile
145                 150                 155                 160 
Ala Val Gly Leu Ser Tyr Leu His Phe Lys Gly Ile Phe His Arg Asp
                165                 170                 175     
Leu Thr Ser Lys Asn Cys Leu Ile Lys Arg Asp Glu Asn Gly Tyr Ser
            180                 185                 190         
Ala Val Val Ala Asp Phe Gly Leu Ala Glu Lys Ile Pro Asp Val Ser
        195                 200                 205             
Met Gly Ser Glu Lys Leu Ala Val Val Gly Ser Pro Phe Trp Met Ala
    210                 215                 220                 
Pro Glu Val Leu Arg Asp Glu Pro Tyr Asn Glu Lys Ala Asp Val Phe
225                 230                 235                 240 
Ser Tyr Gly Ile Ile Leu Cys Glu Ile Ile Ala Arg Ile Gln Ala Asp
                245                 250                 255     
Pro Asp Tyr Leu Pro Arg Thr Glu Asn Phe Gly Leu Asp Tyr Asp Ala
            260                 265                 270         
Phe Gln His Met Val Gly Asp Cys Pro Pro Asp Phe Leu Gln Leu Thr
        275                 280                 285             
Phe Asn Cys Cys Asn Met Asp Pro Lys Leu Arg Pro Ser Phe Val Glu
    290                 295                 300                 
Ile Gly Lys Thr Leu Glu Glu Ile Leu Ser Arg Leu Gln Glu Glu Glu
305                 310                 315                 320 
Gln Glu Arg Asp Arg Lys Leu Gln Pro Thr Ala Arg Gly Leu Leu Glu
                325                 330                 335     
Lys Ala Pro Gly Val Lys Arg Leu Ser Ser Leu Asp Asp Lys Ile Pro
            340                 345                 350         
His Lys Ser Pro Cys Pro Arg Arg Thr Ile Trp Leu Ser Arg Ser Gln
        355                 360                 365             
Ser Asp Ile Phe Ser Arg Lys Pro Pro Arg Thr Val Ser Val Leu Asp
    370                 375                 380                 
Pro Tyr Tyr Arg Pro Arg Asp Gly Ala Ala Arg Thr Pro Lys Val Asn
385                 390                 395                 400 
Pro Phe Ser Ala Arg Gln Asp Leu Met Gly Gly Lys Ile Lys Phe Phe
                405                 410                 415     
Asp Leu Pro Ser Lys Ser Val Ile Ser Leu Val Phe Asp Leu Asp Ala
            420                 425                 430         
Pro Gly Pro Gly Thr Met Pro Leu Ala Asp Trp Gln Glu Pro Leu Ala
        435                 440                 445             
Pro Pro Ile Arg Arg Trp Arg Ser Leu Pro Gly Ser Pro Glu Phe Leu
    450                 455                 460                 
His Gln Glu Ala Cys Pro Phe Val Gly Arg Glu Glu Ser Leu Ser Asp
465                 470                 475                 480 
Gly Pro Pro Pro Arg Leu Ser Ser Leu Lys Tyr Arg Val Lys Glu Ile
                485                 490                 495     
Pro Pro Phe Arg Ala Ser Ala Leu Pro Ala Ala Gln Ala His Glu Ala
            500                 505                 510         
Met Asp Cys Ser Ile Leu Gln Glu Glu Asn Gly Phe Gly Ser Arg Pro
        515                 520                 525             
Gln Gly Thr Ser Pro Cys Pro Ala Gly Ala Ser Glu Glu Met Glu Val
    530                 535                 540                 
Glu Glu Arg Pro Ala Gly Ser Thr Pro Ala Thr Phe Ser Thr Ser Gly
545                 550                 555                 560 
Ile Gly Leu Gln Thr Gln Gly Lys Gln Asp Gly
                565                 570     


<210> 1915
<211> 154
<212> PRT
<213> Homo sapiens

<400> 1915
Met Gly Ser Leu Ser Gly Leu Arg Leu Ala Ala Gly Ser Cys Phe Arg
 1               5                  10                  15      
Leu Cys Glu Arg Asp Val Ser Ser Ser Leu Arg Leu Thr Arg Ser Ser
            20                  25                  30          
Asp Leu Lys Arg Ile Asn Gly Phe Cys Thr Lys Pro Gln Glu Ser Pro
        35                  40                  45              
Gly Ala Pro Ser Arg Thr Tyr Asn Arg Val Pro Leu His Lys Pro Thr
    50                  55                  60                  
Asp Trp Gln Lys Lys Ile Leu Ile Trp Ser Gly Arg Phe Lys Lys Glu
65                  70                  75                  80  
Asp Glu Ile Pro Glu Thr Val Ser Leu Glu Met Leu Asp Ala Ala Lys
                85                  90                  95      
Asn Lys Met Arg Val Lys Ile Ser Tyr Leu Met Ile Ala Leu Thr Val
            100                 105                 110         
Val Gly Cys Ile Phe Met Val Ile Glu Gly Lys Lys Ala Ala Gln Arg
        115                 120                 125             
His Glu Thr Leu Thr Ser Leu Asn Leu Glu Lys Lys Ala Arg Leu Lys
    130                 135                 140                 
Glu Glu Ala Ala Met Lys Ala Lys Thr Glu
145                 150                 


<210> 1916
<211> 970
<212> PRT
<213> Homo sapiens

<400> 1916
Met Ala Thr Cys Ile Gly Glu Lys Ile Glu Asp Phe Lys Val Gly Asn
 1               5                  10                  15      
Leu Leu Gly Lys Gly Ser Phe Ala Gly Val Tyr Arg Ala Glu Ser Ile
            20                  25                  30          
His Thr Gly Leu Glu Val Ala Ile Lys Met Ile Asp Lys Lys Ala Met
        35                  40                  45              
Tyr Lys Ala Gly Met Val Gln Arg Val Gln Asn Glu Val Lys Ile His
    50                  55                  60                  
Cys Gln Leu Lys His Pro Ser Ile Leu Glu Leu Tyr Asn Tyr Phe Glu
65                  70                  75                  80  
Asp Ser Asn Tyr Val Tyr Leu Val Leu Glu Met Cys His Asn Gly Glu
                85                  90                  95      
Met Asn Arg Tyr Leu Lys Asn Arg Val Lys Pro Phe Ser Glu Asn Glu
            100                 105                 110         
Ala Arg His Phe Met His Gln Ile Ile Thr Gly Met Leu Tyr Leu His
        115                 120                 125             
Ser His Gly Ile Leu His Arg Asp Leu Thr Leu Ser Asn Leu Leu Leu
    130                 135                 140                 
Thr Arg Asn Met Asn Ile Lys Ile Ala Asp Phe Gly Leu Ala Thr Gln
145                 150                 155                 160 
Leu Lys Met Pro His Glu Lys His Tyr Thr Leu Cys Gly Thr Pro Asn
                165                 170                 175     
Tyr Ile Ser Pro Glu Ile Ala Thr Arg Ser Ala His Gly Leu Glu Ser
            180                 185                 190         
Asp Val Trp Ser Leu Gly Cys Met Phe Tyr Thr Leu Leu Ile Gly Arg
        195                 200                 205             
Pro Pro Phe Asp Thr Asp Thr Val Lys Asn Thr Leu Asn Lys Val Val
    210                 215                 220                 
Leu Ala Asp Tyr Glu Met Pro Ser Phe Leu Ser Ile Glu Ala Lys Asp
225                 230                 235                 240 
Leu Ile His Gln Leu Leu Arg Arg Asn Pro Ala Asp Arg Leu Ser Leu
                245                 250                 255     
Ser Ser Val Leu Asp His Pro Phe Met Ser Arg Asn Ser Ser Thr Lys
            260                 265                 270         
Ser Lys Asp Leu Gly Thr Val Glu Asp Ser Ile Asp Ser Gly His Ala
        275                 280                 285             
Thr Ile Ser Thr Ala Ile Thr Ala Ser Ser Ser Thr Ser Ile Ser Gly
    290                 295                 300                 
Ser Leu Phe Asp Lys Arg Arg Leu Leu Ile Gly Gln Pro Leu Pro Asn
305                 310                 315                 320 
Lys Met Thr Val Phe Pro Lys Asn Lys Ser Ser Thr Asp Phe Ser Ser
                325                 330                 335     
Ser Gly Asp Gly Asn Ser Phe Tyr Thr Gln Trp Gly Asn Gln Glu Thr
            340                 345                 350         
Ser Asn Ser Gly Arg Gly Arg Val Ile Gln Asp Ala Glu Glu Arg Pro
        355                 360                 365             
His Ser Arg Tyr Leu Arg Arg Ala Tyr Ser Ser Asp Arg Ser Gly Thr
    370                 375                 380                 
Ser Asn Ser Gln Ser Gln Ala Lys Thr Tyr Thr Met Glu Arg Cys His
385                 390                 395                 400 
Ser Ala Glu Met Leu Ser Val Ser Lys Arg Ser Gly Gly Gly Glu Asn
                405                 410                 415     
Glu Glu Arg Tyr Ser Pro Thr Asp Asn Asn Ala Asn Ile Phe Asn Phe
            420                 425                 430         
Phe Lys Glu Lys Thr Ser Ser Ser Ser Gly Ser Phe Glu Arg Pro Asp
        435                 440                 445             
Asn Asn Gln Ala Leu Ser Asn His Leu Cys Pro Gly Lys Thr Pro Phe
    450                 455                 460                 
Pro Phe Ala Asp Pro Thr Pro Gln Thr Glu Thr Val Gln Gln Trp Phe
465                 470                 475                 480 
Gly Asn Leu Gln Ile Asn Ala His Leu Arg Lys Thr Thr Glu Tyr Asp
                485                 490                 495     
Ser Ile Ser Pro Asn Arg Asp Phe Gln Gly His Pro Asp Leu Gln Lys
            500                 505                 510         
Asp Thr Ser Lys Asn Ala Trp Thr Asp Thr Lys Val Lys Lys Asn Ser
        515                 520                 525             
Asp Ala Ser Asp Asn Ala His Ser Val Lys Gln Gln Asn Thr Met Lys
    530                 535                 540                 
Tyr Met Thr Ala Leu His Ser Lys Pro Glu Ile Ile Gln Gln Glu Cys
545                 550                 555                 560 
Val Phe Gly Ser Asp Pro Leu Ser Glu Gln Ser Lys Thr Arg Gly Met
                565                 570                 575     
Glu Pro Pro Trp Gly Tyr Gln Asn Arg Thr Leu Arg Ser Ile Thr Ser
            580                 585                 590         
Pro Leu Val Ala His Arg Leu Lys Pro Ile Arg Gln Lys Thr Lys Lys
        595                 600                 605             
Ala Val Val Ser Ile Leu Asp Ser Glu Glu Val Cys Val Glu Leu Val
    610                 615                 620                 
Lys Glu Tyr Ala Ser Gln Glu Tyr Val Lys Glu Val Leu Gln Ile Ser
625                 630                 635                 640 
Ser Asp Gly Asn Thr Ile Thr Ile Tyr Tyr Pro Asn Gly Gly Arg Gly
                645                 650                 655     
Phe Pro Leu Ala Asp Arg Pro Pro Ser Pro Thr Asp Asn Ile Ser Arg
            660                 665                 670         
Tyr Ser Phe Asp Asn Leu Pro Glu Lys Tyr Trp Arg Lys Tyr Gln Tyr
        675                 680                 685             
Ala Ser Arg Phe Val Gln Leu Val Arg Ser Lys Ser Pro Lys Ile Thr
    690                 695                 700                 
Tyr Phe Thr Arg Tyr Ala Lys Cys Ile Leu Met Glu Asn Ser Pro Gly
705                 710                 715                 720 
Ala Asp Phe Glu Val Trp Phe Tyr Asp Gly Val Lys Ile His Lys Thr
                725                 730                 735     
Glu Asp Phe Ile Gln Val Ile Glu Lys Thr Gly Lys Ser Tyr Thr Leu
            740                 745                 750         
Lys Ser Glu Ser Glu Val Asn Ser Leu Lys Glu Glu Ile Lys Met Tyr
        755                 760                 765             
Met Asp His Ala Asn Glu Gly His Arg Ile Cys Leu Ala Leu Glu Ser
    770                 775                 780                 
Ile Ile Ser Glu Glu Glu Arg Lys Thr Arg Ser Ala Pro Phe Phe Pro
785                 790                 795                 800 
Ile Ile Ile Gly Arg Lys Pro Gly Ser Thr Ser Ser Pro Lys Ala Leu
                805                 810                 815     
Ser Pro Pro Pro Ser Val Asp Ser Asn Tyr Pro Thr Arg Glu Arg Ala
            820                 825                 830         
Ser Phe Asn Arg Met Val Met His Ser Ala Ala Ser Pro Thr Gln Ala
        835                 840                 845             
Pro Ile Leu Asn Pro Ser Met Val Thr Asn Glu Gly Leu Gly Leu Thr
    850                 855                 860                 
Thr Thr Ala Ser Gly Thr Asp Ile Ser Ser Asn Ser Leu Lys Asp Cys
865                 870                 875                 880 
Leu Pro Lys Ser Ala Gln Leu Leu Lys Ser Val Phe Val Lys Asn Val
                885                 890                 895     
Gly Trp Ala Thr Gln Leu Thr Ser Gly Ala Val Trp Val Gln Phe Asn
            900                 905                 910         
Asp Gly Ser Gln Leu Val Val Gln Ala Gly Val Ser Ser Ile Ser Tyr
        915                 920                 925             
Thr Ser Pro Asn Gly Gln Thr Thr Arg Tyr Gly Glu Asn Glu Lys Leu
    930                 935                 940                 
Pro Asp Tyr Ile Lys Gln Lys Leu Gln Cys Leu Ser Ser Ile Leu Leu
945                 950                 955                 960 
Met Phe Ser Asn Pro Thr Pro Asn Phe His
                965                 970 


<210> 1917
<211> 470
<212> PRT
<213> Homo sapiens

<400> 1917
Met Gly Gln Asn Leu Ile Leu Asn Met Asn Asp His Gly Phe Val Val
 1               5                  10                  15      
Cys Ala Phe Asn Arg Thr Val Ser Lys Val Asp Asp Phe Leu Ala Asn
            20                  25                  30          
Glu Ala Lys Gly Thr Lys Val Val Gly Ala Gln Ser Leu Lys Glu Met
        35                  40                  45              
Val Ser Lys Leu Lys Lys Pro Arg Arg Ile Ile Leu Leu Val Lys Ala
    50                  55                  60                  
Gly Gln Ala Val Asp Asp Phe Ile Glu Lys Leu Val Pro Leu Leu Asp
65                  70                  75                  80  
Thr Gly Asp Ile Ile Ile Asp Gly Gly Asn Ser Glu Tyr Arg Asp Thr
                85                  90                  95      
Thr Arg Arg Cys Arg Asp Leu Lys Ala Lys Gly Ile Leu Phe Val Gly
            100                 105                 110         
Ser Gly Val Ser Gly Gly Glu Glu Gly Ala Arg Tyr Gly Pro Ser Leu
        115                 120                 125             
Met Pro Gly Gly Asn Lys Glu Ala Trp Pro His Ile Lys Thr Ile Phe
    130                 135                 140                 
Gln Gly Ile Ala Ala Lys Val Gly Thr Gly Glu Pro Cys Cys Asp Trp
145                 150                 155                 160 
Val Gly Asp Glu Gly Ala Gly His Phe Val Lys Met Val His Asn Gly
                165                 170                 175     
Ile Glu Tyr Gly Asp Met Gln Leu Ile Cys Glu Ala Tyr His Leu Met
            180                 185                 190         
Lys Asp Val Leu Gly Met Ala Gln Asp Glu Met Ala Gln Ala Phe Glu
        195                 200                 205             
Asp Trp Asn Lys Thr Glu Leu Asp Ser Phe Leu Ile Glu Ile Thr Ala
    210                 215                 220                 
Asn Ile Leu Lys Phe Gln Asp Thr Asp Gly Lys His Leu Leu Pro Lys
225                 230                 235                 240 
Ile Arg Asp Ser Ala Gly Gln Lys Gly Thr Gly Lys Trp Thr Ala Ile
                245                 250                 255     
Ser Ala Leu Glu Tyr Gly Val Pro Val Thr Leu Ile Gly Glu Ala Val
            260                 265                 270         
Phe Ala Arg Cys Leu Ser Ser Leu Lys Asp Glu Arg Ile Gln Ala Ser
        275                 280                 285             
Lys Lys Leu Lys Gly Pro Gln Lys Phe Gln Phe Asp Gly Asp Lys Lys
    290                 295                 300                 
Ser Phe Leu Glu Asp Ile Arg Lys Ala Leu Tyr Ala Ser Lys Ile Ile
305                 310                 315                 320 
Ser Tyr Ala Gln Gly Phe Met Leu Leu Arg Gln Ala Ala Thr Glu Phe
                325                 330                 335     
Gly Trp Thr Leu Asn Tyr Gly Gly Ile Ala Leu Met Trp Arg Gly Gly
            340                 345                 350         
Cys Ile Ile Arg Ser Val Phe Leu Gly Lys Ile Lys Asp Ala Phe Asp
        355                 360                 365             
Arg Asn Pro Glu Leu Gln Asn Leu Leu Leu Asp Asp Phe Phe Lys Ser
    370                 375                 380                 
Ala Val Glu Asn Cys Gln Asp Ser Trp Arg Arg Ala Val Ser Thr Gly
385                 390                 395                 400 
Val Gln Ala Gly Ile Pro Met Pro Cys Phe Thr Thr Ala Leu Ser Phe
                405                 410                 415     
Tyr Asp Gly Tyr Arg His Glu Met Leu Pro Ala Ser Leu Ile Gln Ala
            420                 425                 430         
Gln Arg Asp Tyr Phe Gly Ala His Thr Tyr Glu Leu Leu Ala Lys Pro
        435                 440                 445             
Gly Gln Phe Ile His Thr Asn Trp Thr Gly His Gly Gly Thr Val Ser
    450                 455                 460                 
Ser Ser Ser Tyr Asn Ala
465                 470 


<210> 1918
<211> 570
<212> PRT
<213> Homo sapiens

<400> 1918
Met Asp Arg Glu Val Lys Glu Gln Tyr Gln Val Leu Ile Gln Ala Lys
 1               5                  10                  15      
Asp Met Gly Gly Gln Leu Gly Gly Leu Ala Gly Thr Thr Ile Val Asn
            20                  25                  30          
Ile Thr Leu Thr Asp Val Asn Asp Asn Pro Pro Arg Phe Pro Lys Ser
        35                  40                  45              
Ile Phe His Leu Lys Val Pro Glu Ser Ser Pro Ile Gly Ser Ala Ile
    50                  55                  60                  
Gly Arg Ile Arg Ala Val Asp Pro Asp Phe Gly Gln Asn Ala Glu Ile
65                  70                  75                  80  
Glu Tyr Asn Ile Val Pro Gly Asp Gly Gly Asn Leu Phe Asp Ile Val
                85                  90                  95      
Thr Asp Glu Asp Thr Gln Glu Gly Val Ile Lys Leu Lys Lys Pro Leu
            100                 105                 110         
Asp Phe Glu Thr Lys Lys Ala Tyr Thr Phe Lys Val Glu Ala Ser Asn
        115                 120                 125             
Leu His Leu Asp His Arg Phe His Ser Ala Gly Pro Phe Lys Asp Thr
    130                 135                 140                 
Ala Thr Val Lys Ile Ser Val Leu Asp Val Asp Glu Pro Pro Val Phe
145                 150                 155                 160 
Ser Lys Pro Leu Tyr Thr Met Glu Val Tyr Glu Asp Thr Pro Val Gly
                165                 170                 175     
Thr Ile Ile Gly Ala Val Thr Ala Gln Asp Leu Asp Val Gly Ser Ser
            180                 185                 190         
Ala Val Arg Tyr Phe Ile Asp Trp Lys Ser Asp Gly Asp Ser Tyr Phe
        195                 200                 205             
Thr Ile Asp Gly Asn Glu Gly Thr Ile Ala Thr Asn Glu Leu Leu Asp
    210                 215                 220                 
Arg Glu Ser Thr Ala Gln Tyr Asn Phe Ser Ile Ile Ala Ser Lys Val
225                 230                 235                 240 
Ser Asn Pro Leu Leu Thr Ser Lys Val Asn Ile Leu Ile Asn Val Leu
                245                 250                 255     
Asp Val Asn Glu Phe Pro Pro Glu Ile Ser Val Pro Tyr Glu Thr Ala
            260                 265                 270         
Val Cys Glu Asn Ala Lys Pro Gly Gln Ile Ile Gln Ile Val Ser Ala
        275                 280                 285             
Ala Asp Arg Asp Leu Ser Pro Ala Gly Gln Gln Phe Ser Phe Arg Leu
    290                 295                 300                 
Ser Pro Glu Ala Ala Ile Lys Pro Asn Phe Thr Val Arg Asp Phe Arg
305                 310                 315                 320 
Asn Asn Thr Ala Gly Ile Glu Thr Arg Arg Asn Gly Tyr Ser Arg Arg
                325                 330                 335     
Gln Gln Glu Leu Tyr Phe Leu Pro Val Val Ile Glu Asp Ser Ser Tyr
            340                 345                 350         
Pro Val Gln Ser Ser Thr Asn Thr Met Thr Ile Arg Val Cys Arg Cys
        355                 360                 365             
Asp Ser Asp Gly Thr Ile Leu Ser Cys Asn Val Glu Ala Ile Phe Leu
    370                 375                 380                 
Pro Val Gly Leu Ser Thr Gly Ala Leu Ile Ala Ile Leu Leu Cys Ile
385                 390                 395                 400 
Val Ile Leu Leu Ala Ile Val Val Leu Tyr Val Ala Leu Arg Arg Gln
                405                 410                 415     
Lys Lys Lys Asp Thr Leu Met Thr Ser Lys Glu Asp Ile Arg Asp Asn
            420                 425                 430         
Val Ile His Tyr Asp Asp Glu Gly Gly Gly Glu Glu Asp Thr Gln Ala
        435                 440                 445             
Phe Asp Ile Gly Ala Leu Arg Asn Pro Lys Val Ile Glu Glu Asn Lys
    450                 455                 460                 
Ile Arg Arg Asp Ile Lys Pro Asp Ser Leu Cys Leu Pro Arg Gln Arg
465                 470                 475                 480 
Pro Pro Met Glu Asp Asn Thr Asp Ile Arg Asp Phe Ile His Gln Arg
                485                 490                 495     
Leu Gln Glu Asn Asp Val Asp Pro Thr Ala Pro Pro Tyr Asp Ser Leu
            500                 505                 510         
Ala Thr Tyr Ala Tyr Glu Gly Ser Gly Ser Val Ala Glu Ser Leu Ser
        515                 520                 525             
Ser Ile Asp Ser Leu Thr Thr Glu Ala Asp Gln Asp Tyr Asp Tyr Leu
    530                 535                 540                 
Thr Asp Trp Gly Pro Arg Phe Lys Val Leu Ala Asp Met Phe Gly Glu
545                 550                 555                 560 
Glu Glu Ser Tyr Asn Pro Asp Lys Val Thr
                565                 570 


<210> 1919
<211> 343
<212> PRT
<213> Homo sapiens

<400> 1919
Met Leu Ala Thr Arg Leu Ser Arg Pro Leu Ser Arg Leu Pro Gly Lys
 1               5                  10                  15      
Thr Leu Ser Ala Cys Asp Arg Glu Asn Gly Ala Arg Arg Pro Leu Leu
            20                  25                  30          
Leu Gly Ser Thr Ser Phe Ile Pro Ile Gly Arg Arg Thr Tyr Ala Ser
        35                  40                  45              
Ala Ala Glu Pro Val Gly Ser Lys Ala Val Leu Val Thr Gly Cys Asp
    50                  55                  60                  
Ser Gly Phe Gly Phe Ser Leu Ala Lys His Leu His Ser Lys Gly Phe
65                  70                  75                  80  
Leu Val Phe Ala Gly Cys Leu Met Lys Asp Lys Gly His Asp Gly Val
                85                  90                  95      
Lys Glu Leu Asp Ser Leu Asn Ser Asp Arg Leu Arg Thr Val Gln Leu
            100                 105                 110         
Asn Val Cys Ser Ser Glu Glu Val Glu Lys Val Val Glu Ile Val Arg
        115                 120                 125             
Ser Ser Leu Lys Asp Pro Glu Lys Gly Met Trp Gly Leu Val Asn Asn
    130                 135                 140                 
Ala Gly Ile Ser Thr Phe Gly Glu Val Glu Phe Thr Ser Leu Glu Thr
145                 150                 155                 160 
Tyr Lys Gln Val Ala Glu Val Asn Leu Trp Gly Thr Val Arg Met Thr
                165                 170                 175     
Lys Ser Phe Leu Pro Leu Ile Arg Arg Ala Lys Gly Arg Val Val Asn
            180                 185                 190         
Ile Ser Ser Met Leu Gly Arg Met Ala Asn Pro Ala Arg Ser Pro Tyr
        195                 200                 205             
Cys Ile Thr Lys Phe Gly Val Glu Ala Phe Ser Asp Cys Leu Arg Tyr
    210                 215                 220                 
Glu Met Tyr Pro Leu Gly Val Lys Val Ser Val Val Glu Pro Gly Asn
225                 230                 235                 240 
Phe Ile Ala Ala Thr Ser Leu Tyr Ser Pro Glu Ser Ile Gln Ala Ile
                245                 250                 255     
Ala Lys Lys Met Trp Glu Glu Leu Pro Glu Val Val Arg Lys Asp Tyr
            260                 265                 270         
Gly Lys Lys Tyr Phe Asp Glu Lys Ile Ala Lys Met Glu Thr Tyr Cys
        275                 280                 285             
Ser Ser Gly Ser Thr Asp Thr Ser Pro Val Ile Asp Ala Val Thr His
    290                 295                 300                 
Ala Leu Thr Ala Thr Thr Pro Tyr Thr Arg Tyr His Pro Met Asp Tyr
305                 310                 315                 320 
Tyr Trp Trp Leu Arg Met Gln Ile Met Thr His Leu Pro Gly Ala Ile
                325                 330                 335     
Ser Asp Met Ile Tyr Ile Arg
            340             


<210> 1920
<211> 1124
<212> PRT
<213> Homo sapiens

<400> 1920
Met Ile Leu Asp Ser Glu Lys Thr Ser Glu Thr Ala Ala Lys Gly Val
 1               5                  10                  15      
Asn Thr Gly Gly Arg Glu Pro Asn Thr Met Val Glu Lys Glu Arg Pro
            20                  25                  30          
Leu Ala Asp Lys Lys Ala Gln Arg Pro Phe Glu Arg Ser Asp Phe Ser
        35                  40                  45              
Asp Ser Ile Lys Ile Gln Thr Pro Glu Leu Gly Glu Val Phe Gln Asn
    50                  55                  60                  
Lys Asp Ser Asp Tyr Leu Lys Asn Asp Asn Pro Glu Glu His Leu Lys
65                  70                  75                  80  
Thr Ser Gly Leu Ala Gly Glu Pro Glu Gly Glu Leu Ser Lys Glu Asp
                85                  90                  95      
His Glu Asn Thr Glu Lys Tyr Met Gly Thr Glu Ser Gln Gly Ser Ala
            100                 105                 110         
Ala Ala Glu Pro Glu Asp Asp Ser Phe His Trp Thr Pro His Thr Ser
        115                 120                 125             
Val Glu Pro Gly His Ser Asp Lys Arg Glu Asp Leu Leu Ile Ile Ser
    130                 135                 140                 
Ser Phe Phe Lys Glu Gln Gln Ser Leu Gln Arg Phe Gln Lys Tyr Phe
145                 150                 155                 160 
Asn Val His Glu Leu Glu Ala Leu Leu Gln Glu Met Ser Ser Lys Leu
                165                 170                 175     
Lys Ser Ala Gln Gln Glu Ser Leu Pro Tyr Asn Met Glu Lys Val Leu
            180                 185                 190         
Asp Lys Val Phe Arg Ala Ser Glu Ser Gln Ile Leu Ser Ile Ala Glu
        195                 200                 205             
Lys Met Leu Asp Thr Arg Val Ala Glu Asn Arg Asp Leu Gly Met Asn
    210                 215                 220                 
Glu Asn Asn Ile Phe Glu Glu Ala Ala Val Leu Asp Asp Ile Gln Asp
225                 230                 235                 240 
Leu Ile Tyr Phe Val Arg Tyr Lys His Ser Thr Ala Glu Glu Thr Ala
                245                 250                 255     
Thr Leu Val Met Ala Pro Pro Leu Glu Glu Gly Leu Gly Gly Ala Met
            260                 265                 270         
Glu Glu Met Gln Pro Leu His Glu Asp Asn Phe Ser Arg Glu Lys Thr
        275                 280                 285             
Ala Glu Leu Asn Val Gln Val Pro Glu Glu Pro Thr His Leu Asp Gln
    290                 295                 300                 
Arg Val Ile Gly Asp Thr His Ala Ser Glu Val Ser Gln Lys Pro Asn
305                 310                 315                 320 
Thr Glu Lys Asp Leu Asp Pro Gly Pro Val Thr Thr Glu Asp Thr Pro
                325                 330                 335     
Met Asp Ala Ile Asp Ala Asn Lys Gln Pro Glu Thr Ala Ala Glu Glu
            340                 345                 350         
Pro Ala Ser Val Thr Pro Leu Glu Asn Ala Ile Leu Leu Ile Tyr Ser
        355                 360                 365             
Phe Met Phe Tyr Leu Thr Lys Ser Leu Val Ala Thr Leu Pro Asp Asp
    370                 375                 380                 
Val Gln Pro Gly Pro Asp Phe Tyr Gly Leu Pro Trp Lys Pro Val Phe
385                 390                 395                 400 
Ile Thr Ala Phe Leu Gly Ile Ala Ser Phe Ala Ile Phe Leu Trp Arg
                405                 410                 415     
Thr Val Leu Val Val Lys Asp Arg Val Tyr Gln Val Thr Glu Gln Gln
            420                 425                 430         
Ile Ser Glu Lys Leu Lys Thr Ile Met Lys Glu Asn Thr Glu Leu Val
        435                 440                 445             
Gln Lys Leu Ser Asn Tyr Glu Gln Lys Ile Lys Glu Ser Lys Lys His
    450                 455                 460                 
Val Gln Glu Thr Arg Lys Gln Asn Met Ile Leu Ser Asp Glu Ala Ile
465                 470                 475                 480 
Lys Tyr Lys Asp Lys Ile Lys Thr Leu Glu Lys Asn Gln Glu Ile Leu
                485                 490                 495     
Asp Asp Thr Ala Lys Asn Leu Arg Val Met Leu Glu Ser Glu Arg Glu
            500                 505                 510         
Gln Asn Val Lys Asn Gln Asp Leu Ile Ser Glu Asn Lys Lys Ser Ile
        515                 520                 525             
Glu Lys Leu Lys Asp Val Ile Ser Met Asn Ala Ser Glu Phe Ser Glu
    530                 535                 540                 
Val Gln Ile Ala Leu Asn Glu Ala Lys Leu Ser Glu Glu Lys Val Lys
545                 550                 555                 560 
Ser Glu Cys His Arg Val Gln Glu Glu Asn Ala Arg Leu Lys Lys Lys
                565                 570                 575     
Lys Glu Gln Leu Gln Gln Glu Ile Glu Asp Trp Ser Lys Leu His Ala
            580                 585                 590         
Glu Leu Ser Glu Gln Ile Lys Ser Phe Glu Lys Ser Gln Lys Asp Leu
        595                 600                 605             
Glu Val Ala Leu Thr His Lys Asp Asp Asn Ile Asn Ala Leu Thr Asn
    610                 615                 620                 
Cys Ile Thr Gln Leu Asn Leu Leu Glu Cys Glu Ser Glu Ser Glu Gly
625                 630                 635                 640 
Gln Asn Lys Gly Gly Asn Asp Ser Asp Glu Leu Ala Asn Gly Glu Val
                645                 650                 655     
Gly Gly Asp Arg Asn Glu Lys Met Lys Asn Gln Ile Lys Gln Met Met
            660                 665                 670         
Asp Val Ser Arg Thr Gln Thr Ala Ile Ser Val Val Glu Glu Asp Leu
        675                 680                 685             
Lys Leu Leu Gln Leu Lys Leu Arg Ala Ser Val Ser Thr Lys Cys Asn
    690                 695                 700                 
Leu Glu Asp Gln Val Lys Lys Leu Glu Asp Asp Arg Asn Ser Leu Gln
705                 710                 715                 720 
Ala Ala Lys Ala Gly Leu Glu Asp Glu Cys Lys Thr Leu Arg Gln Lys
                725                 730                 735     
Val Glu Ile Leu Asn Glu Leu Tyr Gln Gln Lys Glu Met Ala Leu Gln
            740                 745                 750         
Lys Lys Leu Ser Gln Glu Glu Tyr Glu Arg Gln Glu Arg Glu His Arg
        755                 760                 765             
Leu Ser Ala Ala Asp Glu Lys Ala Val Ser Ala Ala Glu Glu Val Lys
    770                 775                 780                 
Thr Tyr Lys Arg Arg Ile Glu Glu Met Glu Asp Glu Leu Gln Lys Thr
785                 790                 795                 800 
Glu Arg Ser Phe Lys Asn Gln Ile Ala Thr His Glu Lys Lys Ala His
                805                 810                 815     
Glu Asn Trp Leu Lys Ala Arg Ala Ala Glu Arg Ala Ile Ala Glu Glu
            820                 825                 830         
Lys Arg Glu Ala Ala Asn Leu Arg His Lys Leu Leu Glu Leu Thr Gln
        835                 840                 845             
Lys Met Ala Met Leu Gln Glu Glu Pro Val Ile Val Lys Pro Met Pro
    850                 855                 860                 
Gly Lys Pro Asn Thr Gln Asn Pro Pro Arg Arg Gly Pro Leu Ser Gln
865                 870                 875                 880 
Asn Gly Ser Phe Gly Pro Ser Pro Val Ser Gly Gly Glu Cys Ser Pro
                885                 890                 895     
Pro Leu Thr Val Glu Pro Pro Val Arg Pro Leu Ser Ala Thr Leu Asn
            900                 905                 910         
Arg Arg Asp Met Pro Arg Ser Glu Phe Gly Ser Val Asp Gly Pro Leu
        915                 920                 925             
Pro His Pro Arg Trp Ser Ala Glu Ala Ser Gly Lys Pro Ser Pro Ser
    930                 935                 940                 
Asp Pro Gly Ser Gly Thr Ala Thr Met Met Asn Ser Ser Ser Arg Gly
945                 950                 955                 960 
Ser Ser Pro Thr Arg Val Leu Asp Glu Gly Lys Val Asn Met Ala Pro
                965                 970                 975     
Lys Gly Pro Pro Pro Phe Pro Gly Val Pro Leu Met Ser Thr Pro Met
            980                 985                 990         
Gly Gly Pro Val Pro Pro Pro Ile Arg Tyr Gly Pro Pro Pro Gln Leu
        995                 1000                1005            
Cys Gly Pro Phe Gly Pro Arg Pro Leu Pro Pro Pro Phe Gly Pro Gly
    1010                1015                1020                
Met Arg Pro Pro Leu Gly Leu Arg Glu Phe Ala Pro Gly Val Pro Pro
1025                1030                1035                1040
Gly Arg Arg Asp Leu Pro Leu His Pro Arg Gly Phe Leu Pro Gly His
                1045                1050                1055    
Ala Pro Phe Arg Pro Leu Gly Ser Leu Gly Pro Arg Glu Tyr Phe Ile
            1060                1065                1070        
Pro Gly Thr Arg Leu Pro Pro Pro Thr His Gly Pro Gln Glu Tyr Pro
        1075                1080                1085            
Pro Pro Pro Ala Val Arg Asp Leu Leu Pro Ser Gly Ser Arg Asp Glu
    1090                1095                1100                
Pro Pro Pro Ala Ser Gln Ser Thr Ser Gln Asp Cys Ser Gln Ala Leu
1105                1110                1115                1120
Lys Gln Ser Pro
                


<210> 1921
<211> 322
<212> PRT
<213> Homo sapiens

<400> 1921
Met Tyr Tyr Pro Val Thr Leu Asp Val Leu His Gln Ile Phe Ser Lys
 1               5                  10                  15      
Phe Gly Ala Val Leu Lys Ile Ile Thr Phe Thr Lys Asn Asn Gln Phe
            20                  25                  30          
Gln Ala Leu Leu Gln Tyr Gly Asp Pro Val Asn Ala Gln Gln Ala Lys
        35                  40                  45              
Leu Ala Leu Asp Gly Gln Asn Ile Tyr Asn Ala Cys Cys Thr Leu Arg
    50                  55                  60                  
Ile Asp Phe Ser Lys Leu Val Asn Leu Asn Val Lys Tyr Asn Asn Asp
65                  70                  75                  80  
Lys Ser Arg Asp Tyr Thr Arg Pro Asp Leu Pro Ser Gly Asp Gly Gln
                85                  90                  95      
Pro Ala Leu Asp Pro Ala Ile Ala Ala Ala Phe Ala Lys Glu Thr Ser
            100                 105                 110         
Leu Leu Ala Val Pro Gly Ala Leu Ser Pro Leu Ala Ile Pro Asn Ala
        115                 120                 125             
Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Arg Val Gly Met Pro Gly
    130                 135                 140                 
Val Ser Ala Gly Gly Asn Thr Val Leu Leu Val Ser Asn Leu Asn Glu
145                 150                 155                 160 
Glu Met Val Thr Pro Gln Ser Leu Phe Thr Leu Phe Gly Val Tyr Gly
                165                 170                 175     
Asp Val Gln Arg Val Lys Ile Leu Tyr Asn Lys Lys Asp Ser Ala Leu
            180                 185                 190         
Ile Gln Met Ala Asp Gly Asn Gln Ser Gln Leu Ala Met Asn His Leu
        195                 200                 205             
Asn Gly Gln Lys Met Tyr Gly Lys Ile Ile Arg Val Thr Leu Ser Lys
    210                 215                 220                 
His Gln Thr Val Gln Leu Pro Arg Glu Gly Leu Asp Asp Gln Gly Leu
225                 230                 235                 240 
Thr Lys Asp Phe Gly Asn Ser Pro Leu His Arg Phe Lys Lys Pro Gly
                245                 250                 255     
Ser Lys Asn Phe Gln Asn Ile Phe Pro Pro Ser Ala Thr Leu His Leu
            260                 265                 270         
Ser Asn Ile Pro Pro Ser Val Ala Glu Glu Asp Leu Arg Thr Leu Phe
        275                 280                 285             
Ala Asn Thr Gly Gly Thr Val Lys Ala Phe Asn Phe Val Ser Glu Glu
    290                 295                 300                 
Ile Thr Lys Trp Leu Phe Phe Arg Trp Gln Gln Trp Lys Lys Leu Phe
305                 310                 315                 320 
Arg Pro
        


<210> 1922
<211> 126
<212> PRT
<213> Homo sapiens

<400> 1922
Met Trp Tyr Leu Ala Lys Leu Ile Arg Gly Met Ser Ile Asp Gln Ala
 1               5                  10                  15      
Leu Ala Gln Leu Glu Phe Asn Asp Lys Lys Gly Ala Lys Ile Ile Lys
            20                  25                  30          
Glu Val Leu Leu Glu Ala Gln Asp Met Ala Val Arg Asp His Asn Val
        35                  40                  45              
Glu Phe Arg Ser Asn Leu Tyr Ile Ala Glu Ser Thr Ser Gly Arg Gly
    50                  55                  60                  
Gln Cys Leu Lys Arg Ile Arg Tyr His Gly Arg Gly Arg Phe Gly Ile
65                  70                  75                  80  
Met Glu Lys Val Tyr Cys His Tyr Phe Val Lys Leu Val Glu Gly Pro
                85                  90                  95      
Pro Pro Pro Pro Glu Pro Pro Lys Thr Ala Val Ala His Ala Lys Glu
            100                 105                 110         
Tyr Ile Gln Gln Leu Arg Ser Arg Thr Ile Val His Thr Leu
        115                 120                 125     


<210> 1923
<211> 414
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 198, 199, 200, 201, 202, 203, 204, 205, 206, 207, 208, 209,
210, 211, 212, 213, 214, 215, 216, 217, 218, 219, 220, 221,
222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233,
234, 235, 236, 237
<223> Xaa = Any Amino Acid

<400> 1923
Met Ala Ala Ser Ile Val Arg Arg Gly Met Leu Leu Ala Arg Gln Val
 1               5                  10                  15      
Val Leu Pro Gln Leu Ser Pro Ala Gly Lys Arg Tyr Leu Leu Ser Ser
            20                  25                  30          
Ala Tyr Val Asp Ser His Lys Trp Glu Ala Arg Glu Lys Glu His Tyr
        35                  40                  45              
Cys Leu Ala Asp Leu Ala Ser Leu Met Asp Lys Thr Phe Glu Arg Lys
    50                  55                  60                  
Leu Pro Val Ser Ser Leu Thr Ile Ser Arg Leu Ile Asp Asn Ile Ser
65                  70                  75                  80  
Ser Arg Glu Glu Ile Asp His Ala Glu Tyr Tyr Leu Tyr Lys Phe Arg
                85                  90                  95      
His Ser Pro Asn Cys Trp Tyr Leu Arg Asn Trp Thr Ile His Thr Trp
            100                 105                 110         
Ile Arg Gln Cys Leu Lys Tyr Asp Ala Gln Asp Lys Ala Leu Tyr Thr
        115                 120                 125             
Leu Val Asn Lys Val Gln Tyr Gly Ile Phe Pro Asp Asn Phe Thr Phe
    130                 135                 140                 
Asn Leu Leu Met Asp Ser Phe Ile Lys Lys Glu Asn Tyr Lys Asp Ala
145                 150                 155                 160 
Leu Ser Val Val Phe Glu Val Met Met Gln Glu Ala Phe Glu Val Pro
                165                 170                 175     
Ser Thr Gln Leu Leu Ser Leu Tyr Val Leu Phe His Cys Leu Ala Lys
            180                 185                 190         
Lys Thr Asp Phe Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
        195                 200                 205             
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    210                 215                 220                 
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Gly Leu
225                 230                 235                 240 
Arg Ala Val Tyr His Asn Met Pro Leu Ile Trp Lys Pro Gly Tyr Leu
                245                 250                 255     
Asp Arg Ala Leu Gln Val Met Glu Lys Val Ala Ala Ser Pro Glu Asp
            260                 265                 270         
Ile Lys Leu Cys Arg Glu Ala Leu Asp Val Leu Gly Ala Val Leu Lys
        275                 280                 285             
Ala Leu Thr Ser Ala Asp Gly Ala Ser Glu Glu Gln Ser Gln Asn Asp
    290                 295                 300                 
Glu Asp Asn Gln Gly Ser Glu Lys Leu Val Glu Gln Leu Asp Ile Glu
305                 310                 315                 320 
Glu Thr Glu Gln Ser Lys Leu Pro Gln Tyr Leu Glu Arg Phe Lys Ala
                325                 330                 335     
Leu His Ser Lys Leu Gln Ala Leu Gly Lys Ile Glu Ser Glu Gly Leu
            340                 345                 350         
Leu Ser Leu Thr Thr Gln Leu Val Lys Glu Lys Leu Ser Thr Cys Glu
        355                 360                 365             
Ala Glu Asp Ile Ala Thr Tyr Glu Gln Asn Leu Gln Gln Trp His Leu
    370                 375                 380                 
Asp Leu Val Gln Leu Ile Gln Arg Glu Gln Gln Gln Arg Glu Gln Ala
385                 390                 395                 400 
Lys Gln Glu Tyr Gln Ala Gln Lys Ala Ala Lys Ala Ser Ala
                405                 410                 


<210> 1924
<211> 67
<212> PRT
<213> Homo sapiens

<400> 1924
Met Asp Glu Ser Asn Leu Arg Asp Leu Asn Arg Lys Ser Asn Gln Val
 1               5                  10                  15      
Lys Thr Cys Lys Ala Lys Ile Glu Leu Leu Gly Ser Tyr Asp Pro Gln
            20                  25                  30          
Lys Gln Leu Ile Ile Glu Asp Pro Tyr Tyr Gly Asn Asp Ser Asp Phe
        35                  40                  45              
Glu Thr Val Tyr Gln Gln Cys Val Arg Cys Cys Arg Ala Phe Leu Glu
    50                  55                  60                  
Lys Ala His
65          


<210> 1925
<211> 889
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236,
237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248,
249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260,
261, 262, 263, 264, 497, 498, 499, 500, 501, 502, 503
<223> Xaa = Any Amino Acid

<221> VARIANT        
<222> 504, 505, 506, 507, 508, 509, 510, 511, 512, 513, 514, 515,
516, 517, 518, 519, 520, 521, 522, 523, 524, 525, 526, 527,
528, 529, 530, 531, 532, 533, 534, 535, 536, 537, 538, 539
<223> Xaa = Any Amino Acid

<400> 1925
Met Thr Phe Leu Phe Ala Asn Leu Lys Asp Arg Asp Phe Leu Val Gln
 1               5                  10                  15      
Arg Ile Ser Asp Phe Leu Gln Gln Thr Thr Ser Lys Ile Tyr Ser Asp
            20                  25                  30          
Lys Glu Phe Ala Gly Ser Tyr Asn Ser Ser Asp Asp Glu Val Tyr Ser
        35                  40                  45              
Arg Pro Ser Ser Leu Val Ser Ser Ser Pro Gln Arg Ser Thr Ser Ser
    50                  55                  60                  
Asp Ala Asp Gly Glu Arg Gln Phe Asn Leu Asn Gly Asn Ser Val Pro
65                  70                  75                  80  
Thr Ala Thr Gln Thr Leu Met Thr Met Tyr Arg Arg Arg Ser Pro Glu
                85                  90                  95      
Glu Phe Asn Pro Lys Leu Ala Lys Glu Phe Leu Lys Glu Gln Ala Trp
            100                 105                 110         
Lys Ile His Phe Ala Glu Tyr Gly Gln Gly Ile Cys Met Tyr Arg Thr
        115                 120                 125             
Glu Lys Thr Arg Glu Leu Val Leu Lys Gly Ile Pro Glu Ser Met Arg
    130                 135                 140                 
Gly Glu Leu Trp Leu Leu Leu Ser Gly Ala Ile Asn Glu Lys Ala Thr
145                 150                 155                 160 
His Pro Gly Tyr Tyr Glu Asp Leu Val Glu Lys Ser Met Gly Lys Tyr
                165                 170                 175     
Asn Leu Ala Thr Glu Glu Ile Glu Arg Asp Leu His Arg Ser Leu Pro
            180                 185                 190         
Glu His Pro Ala Phe Gln Asn Glu Met Gly Ile Ala Ala Leu Arg Arg
        195                 200                 205             
Val Leu Thr Ala Tyr Ala Phe Arg Asn Pro Asn Ile Gly Tyr Cys Gln
    210                 215                 220                 
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
225                 230                 235                 240 
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
                245                 250                 255     
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Leu Val Asp Gln Gly Val Phe
            260                 265                 270         
Glu Glu Leu Ala Arg Asp Tyr Val Pro Gln Leu Tyr Asp Cys Met Gln
        275                 280                 285             
Asp Leu Gly Val Ile Ser Thr Ile Ser Leu Ser Trp Phe Leu Thr Leu
    290                 295                 300                 
Phe Leu Ser Val Met Pro Phe Glu Ser Ala Val Val Val Val Asp Cys
305                 310                 315                 320 
Phe Phe Tyr Glu Gly Ile Lys Val Ile Phe Gln Leu Ala Leu Thr Val
                325                 330                 335     
Leu Asp Ala Asn Val Asp Lys Leu Leu Asn Cys Lys Asp Asp Gly Glu
            340                 345                 350         
Ala Met Thr Val Leu Gly Arg Tyr Leu Asp Ser Val Thr Asn Lys Asp
        355                 360                 365             
Ser Thr Leu Pro Pro Ile Pro His Leu His Ser Leu Leu Ser Asp Asp
    370                 375                 380                 
Val Glu Pro Tyr Pro Glu Val Asp Ile Phe Arg Leu Ile Arg Thr Ser
385                 390                 395                 400 
Tyr Glu Lys Phe Gly Thr Ile Arg Ala Asp Leu Ile Glu Gln Met Arg
                405                 410                 415     
Phe Lys Gln Arg Leu Lys Val Ile Gln Thr Leu Glu Asp Thr Thr Lys
            420                 425                 430         
Arg Asn Val Val Arg Thr Ile Val Thr Glu Thr Ser Phe Thr Ile Asp
        435                 440                 445             
Glu Leu Glu Glu Leu Tyr Ala Leu Phe Lys Ala Glu His Leu Thr Ser
    450                 455                 460                 
Cys Tyr Trp Gly Gly Ser Ser Asn Ala Leu Asp Arg His Asp Pro Ser
465                 470                 475                 480 
Leu Pro Tyr Leu Glu Gln Tyr Arg Ile Asp Phe Glu Gln Phe Lys Gly
                485                 490                 495     
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            500                 505                 510         
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
        515                 520                 525             
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Ala Cys His Gly
    530                 535                 540                 
Asp Leu Thr Glu Lys Leu Lys Leu Leu Tyr Lys Met His Val Leu Pro
545                 550                 555                 560 
Glu Pro Ser Ser Asp Gln Asp Glu Pro Asp Ser Ala Phe Glu Ala Thr
                565                 570                 575     
Gln Tyr Phe Phe Glu Asp Ile Thr Pro Glu Cys Thr His Val Val Gly
            580                 585                 590         
Leu Asp Ser Arg Ser Lys Gln Gly Ala Asp Asp Gly Phe Val Thr Val
        595                 600                 605             
Ser Leu Lys Pro Asp Lys Gly Lys Arg Ala Asn Ser Gln Glu Asn Arg
    610                 615                 620                 
Asn Tyr Leu Arg Leu Trp Thr Pro Glu Asn Lys Ser Lys Ser Lys Asn
625                 630                 635                 640 
Ala Lys Asp Leu Pro Lys Leu Asn Gln Gly Gln Phe Ile Glu Leu Cys
                645                 650                 655     
Lys Thr Met Tyr Asn Met Phe Ser Glu Asp Pro Asn Glu Gln Glu Leu
            660                 665                 670         
Tyr His Ala Thr Ala Ala Val Thr Ser Leu Leu Leu Glu Ile Gly Glu
        675                 680                 685             
Val Gly Lys Leu Phe Val Ala Gln Pro Ala Lys Glu Gly Gly Ser Gly
    690                 695                 700                 
Gly Ser Gly Pro Ser Cys His Gln Gly Ile Pro Gly Val Leu Phe Pro
705                 710                 715                 720 
Lys Lys Gly Pro Gly Gln Pro Tyr Val Val Glu Ser Val Glu Pro Leu
                725                 730                 735     
Pro Ala Ser Leu Ala Pro Asp Ser Glu Glu His Ser Leu Gly Gly Gln
            740                 745                 750         
Met Glu Asp Ile Lys Leu Glu Asp Ser Ser Pro Arg Asp Asn Gly Ala
        755                 760                 765             
Cys Ser Ser Met Leu Ile Ser Asp Asp Asp Thr Lys Asp Asp Ser Ser
    770                 775                 780                 
Met Ser Ser Tyr Ser Val Leu Ser Ala Gly Ser His Glu Glu Asp Lys
785                 790                 795                 800 
Leu His Cys Glu Asp Ile Gly Glu Asp Thr Val Leu Val Arg Ser Gly
                805                 810                 815     
Gln Gly Thr Ala Ala Leu Pro Arg Ser Thr Ser Leu Asp Arg Asp Trp
            820                 825                 830         
Ala Ile Thr Phe Glu Gln Phe Leu Ala Ser Leu Leu Thr Glu Pro Ala
        835                 840                 845             
Leu Val Lys Tyr Phe Asp Lys Pro Val Cys Met Met Ala Arg Ile Thr
    850                 855                 860                 
Ser Ala Lys Asn Ile Arg Met Met Gly Lys Pro Leu Thr Ser Ala Ser
865                 870                 875                 880 
Asp Tyr Glu Ile Ser Ala Met Ser Gly
                885                 


<210> 1926
<211> 149
<212> PRT
<213> Homo sapiens

<400> 1926
Met Val Phe Leu Thr Ala Gln Leu Trp Leu Arg Asn Arg Val Thr Asp
 1               5                  10                  15      
Arg Tyr Phe Arg Ile Gln Glu Val Leu Lys His Ala Arg His Phe Arg
            20                  25                  30          
Gly Arg Lys Asn Arg Cys Tyr Arg Leu Ala Val Arg Thr Val Ile Arg
        35                  40                  45              
Ala Phe Val Lys Cys Thr Lys Ala Arg Tyr Leu Lys Lys Lys Asn Met
    50                  55                  60                  
Arg Thr Leu Trp Ile Asn Arg Ile Thr Ala Ala Ser Gln Glu His Gly
65                  70                  75                  80  
Leu Lys Tyr Pro Ala Leu Ile Gly Asn Leu Val Lys Cys Gln Val Glu
                85                  90                  95      
Leu Asn Arg Lys Val Leu Ala Asp Leu Ala Ile Tyr Glu Pro Lys Thr
            100                 105                 110         
Phe Lys Ser Leu Ala Ala Leu Ala Ser Arg Arg Arg His Glu Gly Phe
        115                 120                 125             
Ala Ala Ala Leu Gly Asp Gly Lys Glu Pro Glu Gly Ile Phe Ser Arg
    130                 135                 140                 
Val Val Gln Tyr His
145                 


<210> 1927
<211> 214
<212> PRT
<213> Homo sapiens

<400> 1927
Met Arg Thr Leu Leu Leu Val Leu Trp Leu Ala Thr Arg Gly Ser Ala
 1               5                  10                  15      
Leu Tyr Phe His Ile Gly Glu Thr Glu Lys Lys Cys Phe Ile Glu Glu
            20                  25                  30          
Ile Pro Asp Glu Thr Met Val Ile Gly Asn Tyr Arg Thr Gln Leu Tyr
        35                  40                  45              
Asp Lys Gln Arg Glu Glu Tyr Gln Pro Ala Thr Pro Gly Leu Gly Met
    50                  55                  60                  
Phe Val Glu Val Lys Asp Pro Glu Asp Lys Val Ile Leu Ala Arg Gln
65                  70                  75                  80  
Tyr Gly Ser Glu Gly Arg Phe Thr Phe Thr Ser His Thr Pro Gly Glu
                85                  90                  95      
His Gln Ile Cys Leu His Ser Asn Ser Thr Lys Phe Ser Leu Phe Ala
            100                 105                 110         
Gly Gly Met Leu Arg Val His Leu Asp Ile Gln Val Gly Glu His Ala
        115                 120                 125             
Asn Asp Tyr Ala Glu Ile Ala Ala Lys Asp Lys Leu Ser Glu Leu Gln
    130                 135                 140                 
Leu Arg Val Arg Gln Leu Val Glu Gln Val Glu Gln Ile Gln Lys Glu
145                 150                 155                 160 
Gln Asn Tyr Gln Arg Trp Arg Glu Glu Arg Phe Arg Gln Thr Ser Glu
                165                 170                 175     
Ser Thr Asn Gln Arg Val Leu Trp Trp Ser Ile Leu Gln Thr Leu Ile
            180                 185                 190         
Leu Val Ala Ile Gly Val Trp Gln Met Arg His Leu Lys Ser Phe Phe
        195                 200                 205             
Glu Ala Lys Lys Leu Val
    210                 


<210> 1928
<211> 445
<212> PRT
<213> Homo sapiens

<400> 1928
Met Lys Thr Phe Glu Gly Phe Cys Ala Leu His Leu Ala Ala Ser Gln
 1               5                  10                  15      
Gly His Trp Lys Ile Val Gln Ile Leu Leu Glu Ala Gly Ala Asp Pro
            20                  25                  30          
Asn Ala Thr Thr Leu Glu Glu Thr Thr Pro Leu Phe Ser Ala Val Glu
        35                  40                  45              
Asn Gly Gln Ile Asp Val Leu Arg Leu Leu Leu Gln His Gly Ala Asn
    50                  55                  60                  
Val Asn Gly Ser His Ser Met Cys Gly Trp Asn Ser Leu His Gln Ala
65                  70                  75                  80  
Ser Phe Gln Glu Asn Ala Glu Ile Ile Lys Leu Leu Leu Arg Lys Gly
                85                  90                  95      
Ala Asn Lys Glu Cys Gln Asp Asp Phe Gly Ile Thr Pro Leu Phe Val
            100                 105                 110         
Ala Ala Gln Tyr Gly Lys Leu Glu Ser Leu Ser Ile Leu Ile Ser Ser
        115                 120                 125             
Gly Ala Asn Val Asn Cys Gln Ala Leu Asp Lys Ala Thr Pro Leu Phe
    130                 135                 140                 
Ile Ala Ala Gln Glu Gly His Thr Lys Cys Val Glu Leu Leu Leu Ser
145                 150                 155                 160 
Ser Gly Ala Asp Pro Asp Leu Tyr Cys Asn Glu Asp Ser Trp Gln Leu
                165                 170                 175     
Pro Ile His Ala Ala Ala Gln Met Gly His Thr Lys Ile Leu Asp Leu
            180                 185                 190         
Leu Ile Pro Leu Thr Asn Arg Ala Cys Asp Thr Gly Leu Asn Lys Val
        195                 200                 205             
Ser Pro Val Tyr Ser Ala Val Phe Gly Gly His Glu Asp Cys Leu Glu
    210                 215                 220                 
Ile Leu Leu Arg Asn Gly Tyr Ser Pro Asp Ala Gln Ala Cys Leu Val
225                 230                 235                 240 
Phe Gly Phe Ser Ser Pro Val Cys Met Ala Phe Gln Lys Asp Cys Glu
                245                 250                 255     
Phe Phe Gly Ile Val Asn Ile Leu Leu Lys Tyr Gly Ala Gln Ile Asn
            260                 265                 270         
Glu Leu His Leu Ala Tyr Cys Leu Lys Tyr Glu Lys Phe Ser Ile Phe
        275                 280                 285             
Arg Tyr Phe Leu Arg Lys Gly Cys Ser Leu Gly Pro Trp Asn His Ile
    290                 295                 300                 
Tyr Glu Phe Val Asn His Ala Ile Lys Ala Gln Ala Lys Tyr Lys Glu
305                 310                 315                 320 
Trp Leu Pro His Leu Leu Val Ala Gly Phe Asp Pro Leu Ile Leu Leu
                325                 330                 335     
Cys Asn Ser Trp Ile Asp Ser Val Ser Ile Asp Thr Leu Ile Phe Thr
            340                 345                 350         
Leu Glu Phe Thr Asn Trp Lys Thr Leu Ala Pro Ala Val Glu Arg Met
        355                 360                 365             
Leu Ser Ala Arg Ala Ser Asn Ala Trp Ile Leu Gln Gln His Ile Ala
    370                 375                 380                 
Thr Val Pro Ser Leu Thr His Leu Cys Arg Leu Glu Ile Arg Ser Ser
385                 390                 395                 400 
Leu Lys Ser Glu Arg Leu Arg Ser Asp Ser Tyr Ile Ser Gln Leu Pro
                405                 410                 415     
Leu Pro Arg Ser Leu His Asn Tyr Leu Leu Tyr Glu Asp Val Leu Arg
            420                 425                 430         
Met Tyr Glu Val Pro Glu Leu Ala Ala Ile Gln Asp Gly
        435                 440                 445 


<210> 1929
<211> 233
<212> PRT
<213> Homo sapiens

<400> 1929
Met Pro Val Thr Lys Leu Gly Arg Phe Val Lys Asp Met Lys Ile Lys
 1               5                  10                  15      
Ser Leu Glu Glu Ile Tyr Val Phe Ser Leu Pro Ile Lys Glu Ser Glu
            20                  25                  30          
Ile Ile Asp Ser Phe Leu Gly Ala Ser Leu Lys Asp Glu Val Leu Lys
        35                  40                  45              
Ile Met Pro Val Gln Lys Gln Thr Arg Val Gly Gln Arg Thr Arg Phe
    50                  55                  60                  
Lys Ala Phe Val Ala Ile Gly Asp Tyr Asn Gly His Val Gly Leu Gly
65                  70                  75                  80  
Val Lys Cys Ser Lys Glu Val Ala Thr Ala Thr Arg Gly Ala Ile Ile
                85                  90                  95      
Leu Ala Lys Leu Ser Ile Val Pro Val Arg Arg Gly Tyr Trp Gly Asn
            100                 105                 110         
Lys Ile Ser Lys Pro His Thr Val Pro Cys Lys Val Thr Gly Arg Ser
        115                 120                 125             
Gly Ser Val Leu Val His Leu Met Pro Ala Pro Arg Gly Thr Gly Ile
    130                 135                 140                 
Val Ser Ala Pro Val Pro Lys Lys Leu Leu Met Met Ala Gly Ile Asp
145                 150                 155                 160 
Asp Cys Tyr Thr Ser Ala Gln Gly Cys Thr Ala Thr Leu Gly Asn Phe
                165                 170                 175     
Ser Lys Ala Thr Phe Asp Ala Ile Ser Lys Thr Tyr Ser Tyr Leu Thr
            180                 185                 190         
Pro Asp Leu Trp Lys Glu Thr Val Phe Thr Lys Ser Pro Tyr Gln Glu
        195                 200                 205             
Phe Thr Asp His Leu Ile Lys Thr His Thr Arg Val Ser Val Gln Arg
    210                 215                 220                 
Thr Gln Ala Pro Ala Val Ala Thr Thr
225                 230             


<210> 1930
<211> 273
<212> PRT
<213> Homo sapiens

<400> 1930
Met Leu Leu Ser Pro Gly Arg Asn Val Lys Asn Ser Asp Met His Leu
 1               5                  10                  15      
Leu Asp Met Glu Ser Met Gly Lys Ser Tyr Asp Gly Arg Ala Tyr Val
            20                  25                  30          
Ile Thr Gly Met Trp Asn Pro Asn Ala Pro Val Phe Leu Ala Leu Asn
        35                  40                  45              
Glu Glu Thr Pro Lys Asp Lys Gln Val Tyr Met Thr Val Ala Val Asp
    50                  55                  60                  
Met Val Val Thr Glu Val Val Glu Pro Val Arg Phe Leu Leu Glu Thr
65                  70                  75                  80  
Val Val Arg Val Tyr Pro Ala Asn Glu Arg Phe Trp Tyr Phe Ser Arg
                85                  90                  95      
Lys Thr Phe Thr Glu Thr Phe Phe Met Arg Leu Lys Gln Ser Glu Gly
            100                 105                 110         
Lys Gly His Thr Asn Ala Gly Asp Ala Ile Tyr Glu Val Val Ser Leu
        115                 120                 125             
Gln Arg Glu Ser Asp Lys Glu Glu Pro Val Thr Pro Thr Ser Gly Gly
    130                 135                 140                 
Gly Pro Met Ser Pro Gln Asp Asp Glu Ala Glu Glu Glu Ser Asp Asn
145                 150                 155                 160 
Glu Leu Ser Ser Gly Thr Gly Asp Val Ser Lys Asp Cys Pro Glu Lys
                165                 170                 175     
Ile Leu Tyr Ser Trp Gly Glu Leu Leu Gly Lys Trp His Ser Asn Leu
            180                 185                 190         
Gly Ala Arg Pro Lys Gly Leu Ser Thr Leu Val Lys Ser Gly Val Pro
        195                 200                 205             
Glu Ala Leu Arg Ala Glu Val Trp Gln Leu Leu Ala Gly Cys His Asp
    210                 215                 220                 
Asn Gln Ala Met Leu Asp Arg Tyr Arg Ile Leu Ile Thr Lys Val Cys
225                 230                 235                 240 
Trp Ser Leu Leu Glu Val His Ser Arg Pro Cys Leu Pro Gly Tyr His
                245                 250                 255     
Gln Trp Lys Leu Gln Asn Ser Lys Tyr Cys Arg Met Ala Asn Val Ala
            260                 265                 270         
Ala
    


<210> 1931
<211> 311
<212> PRT
<213> Homo sapiens

<400> 1931
Met Leu Ala Asp Asp Met Ala Cys Asn Pro Arg Asn Pro Lys Pro Ala
 1               5                  10                  15      
Thr Val Phe Ser His Lys Asn Met Glu Leu Asn Val Tyr Gly Asp Asp
            20                  25                  30          
Val Glu Val Asp Tyr Arg Ser Tyr Glu Val Thr Val Glu Asn Phe Leu
        35                  40                  45              
Arg Val Leu Thr Gly Arg Ile Pro Pro Ser Thr Pro Arg Ser Lys Arg
    50                  55                  60                  
Leu Leu Ser Asp Asp Arg Ser Asn Ile Leu Ile Tyr Met Thr Gly His
65                  70                  75                  80  
Gly Gly Asn Gly Phe Leu Lys Phe Gln Asp Ser Glu Glu Ile Thr Asn
                85                  90                  95      
Ile Glu Leu Ala Asp Ala Phe Glu Gln Met Trp Gln Lys Arg Arg Tyr
            100                 105                 110         
Asn Glu Leu Leu Phe Ile Ile Asp Thr Cys Gln Gly Ala Ser Met Tyr
        115                 120                 125             
Glu Arg Phe Tyr Ser Pro Asn Ile Met Ala Leu Ala Ser Ser Gln Val
    130                 135                 140                 
Gly Glu Asp Ser Leu Ser His Gln Pro Asp Pro Ala Ile Gly Val His
145                 150                 155                 160 
Leu Met Asp Arg Tyr Thr Phe Tyr Val Leu Glu Phe Leu Glu Glu Ile
                165                 170                 175     
Asn Pro Ala Ser Gln Thr Asn Met Asn Asp Leu Phe Gln Val Cys Pro
            180                 185                 190         
Lys Ser Leu Cys Val Ser Thr Pro Gly His Arg Thr Asp Leu Phe Gln
        195                 200                 205             
Arg Asp Pro Lys Asn Val Leu Ile Thr Asp Phe Phe Gly Ser Val Arg
    210                 215                 220                 
Lys Val Glu Ile Thr Thr Glu Thr Ile Lys Leu Gln Gln Asp Ser Glu
225                 230                 235                 240 
Ile Met Glu Ser Ser Tyr Lys Glu Asp Gln Met Asp Glu Lys Leu Met
                245                 250                 255     
Glu Pro Leu Lys Tyr Ala Glu Gln Leu Pro Val Ala Gln Ile Ile His
            260                 265                 270         
Gln Lys Pro Lys Leu Lys Asp Trp His Pro Pro Gly Gly Phe Ile Leu
        275                 280                 285             
Gly Leu Trp Ala Leu Ile Ile Met Val Phe Phe Lys Thr Tyr Gly Ile
    290                 295                 300                 
Lys His Met Lys Phe Ile Phe
305                 310     


<210> 1932
<211> 155
<212> PRT
<213> Homo sapiens

<400> 1932
Met His Val Thr Ile Val Lys Lys His Leu Ala Ile Ser Gln Gly Leu
 1               5                  10                  15      
Leu Ser Ile Arg Glu His Thr Gln Gly Lys Asn Arg Met Asn Val Met
            20                  25                  30          
Ser Val Glu Asn Pro Leu Ser Ile Ser Gln Thr Ser Gly Tyr Ile Arg
        35                  40                  45              
Glu Leu Thr Gln Gly Lys Asn Pro Met Asn Ala Met Asn Val Gly Lys
    50                  55                  60                  
Arg Phe Thr Val Ser His Ser Ser Leu Ser Ile Asn Gly Leu Thr Gln
65                  70                  75                  80  
Gly Lys Asn Pro Thr Asn Ala Met Asn Val Gly Lys Pro Phe Ala Val
                85                  90                  95      
Ser His Ser Ser Leu Ser Ile Arg Glu Leu Met Leu Gly Lys Asn His
            100                 105                 110         
Thr His Val Thr Asn Val Glu Lys His Ile Ala Thr Ser His Thr Leu
        115                 120                 125             
Gln Tyr Ile Thr Glu Leu Thr Gln Gly Lys Asn Pro Met Asn Val Met
    130                 135                 140                 
Asn Val Glu Asn Pro Phe Thr Val Ser His Ser
145                 150                 155 


<210> 1933
<211> 752
<212> PRT
<213> Homo sapiens

<400> 1933
Met Gly Arg Thr Leu Gln Asn Thr Met Val Asn Leu Gly Leu Gln Asn
 1               5                  10                  15      
Ala Cys Asp Glu Ala Ile Tyr Gln Leu Gly Leu Asp Leu Glu Glu Leu
            20                  25                  30          
Glu Glu Ile Glu Glu Asp Ala Gly Leu Gly Asn Gly Gly Leu Gly Arg
        35                  40                  45              
Leu Ala Ala Cys Phe Leu Asp Ser Met Ala Thr Leu Gly Leu Ala Ala
    50                  55                  60                  
Tyr Gly Tyr Gly Ile Arg Tyr Glu Phe Gly Ile Phe Asn Gln Lys Ile
65                  70                  75                  80  
Val Asn Gly Trp Gln Val Glu Glu Ala Asp Asp Trp Leu Arg Tyr Gly
                85                  90                  95      
Asn Pro Trp Glu Lys Ala Arg Pro Glu Tyr Met Leu Pro Val His Phe
            100                 105                 110         
Tyr Gly Arg Val Glu His Thr Pro Asp Gly Val Lys Trp Leu Asp Thr
        115                 120                 125             
Gln Val Val Leu Ala Met Pro Tyr Asp Thr Pro Val Pro Gly Tyr Lys
    130                 135                 140                 
Asn Asn Thr Val Asn Thr Met Arg Leu Trp Ser Ala Lys Ala Pro Asn
145                 150                 155                 160 
Asp Phe Lys Leu Gln Asp Phe Asn Val Gly Asp Tyr Ile Glu Ala Val
                165                 170                 175     
Leu Asp Arg Asn Leu Ala Glu Asn Ile Ser Arg Val Leu Tyr Pro Asn
            180                 185                 190         
Asp Asn Phe Phe Glu Gly Lys Glu Leu Arg Leu Lys Gln Glu Tyr Phe
        195                 200                 205             
Val Val Ala Ala Thr Leu Gln Asp Ile Ile Arg Arg Phe Lys Ser Ser
    210                 215                 220                 
Lys Phe Gly Cys Arg Asp Pro Val Arg Thr Cys Phe Glu Thr Phe Pro
225                 230                 235                 240 
Asp Lys Val Ala Ile Gln Leu Asn Asp Thr His Pro Ala Leu Ser Ile
                245                 250                 255     
Pro Glu Leu Met Arg Ile Leu Val Asp Val Glu Lys Val Asp Trp Asp
            260                 265                 270         
Lys Ala Trp Glu Ile Thr Lys Lys Thr Cys Ala Tyr Thr Asn His Thr
        275                 280                 285             
Val Leu Pro Glu Ala Leu Glu Arg Trp Pro Val Ser Met Phe Glu Lys
    290                 295                 300                 
Leu Leu Pro Arg His Leu Glu Ile Ile Tyr Ala Ile Asn Gln Arg His
305                 310                 315                 320 
Leu Asp His Val Ala Ala Leu Phe Pro Gly Asp Val Asp Arg Leu Arg
                325                 330                 335     
Arg Met Ser Val Ile Glu Glu Gly Asp Cys Lys Arg Ile Asn Met Ala
            340                 345                 350         
His Leu Cys Val Ile Gly Ser His Ala Val Asn Gly Val Ala Arg Ile
        355                 360                 365             
His Ser Glu Ile Val Lys Gln Ser Val Phe Lys Asp Phe Tyr Glu Leu
    370                 375                 380                 
Glu Pro Glu Lys Phe Gln Asn Lys Thr Asn Gly Ile Thr Pro Arg Arg
385                 390                 395                 400 
Trp Leu Leu Leu Cys Asn Pro Gly Leu Ala Asp Thr Ile Val Glu Lys
                405                 410                 415     
Ile Gly Glu Glu Phe Leu Thr Asp Leu Ser Gln Leu Lys Lys Leu Leu
            420                 425                 430         
Pro Leu Val Ser Asp Glu Val Phe Ile Arg Asp Val Ala Lys Val Lys
        435                 440                 445             
Gln Glu Asn Lys Leu Lys Phe Ser Ala Phe Leu Glu Lys Glu Tyr Lys
    450                 455                 460                 
Val Lys Ile Asn Pro Ser Ser Met Phe Asp Val His Val Lys Arg Ile
465                 470                 475                 480 
His Glu Tyr Lys Arg Gln Leu Leu Asn Cys Leu His Val Val Thr Leu
                485                 490                 495     
Tyr Asn Arg Ile Lys Arg Asp Pro Ala Lys Ala Phe Val Pro Arg Thr
            500                 505                 510         
Val Met Ile Gly Gly Lys Ala Ala Pro Gly Tyr His Met Ala Lys Leu
        515                 520                 525             
Ile Ile Lys Leu Val Thr Ser Ile Gly Asp Val Val Asn His Asp Pro
    530                 535                 540                 
Val Val Gly Asp Arg Leu Lys Val Ile Phe Leu Glu Asn Tyr Arg Val
545                 550                 555                 560 
Ser Leu Ala Glu Lys Val Ile Pro Ala Ala Asp Leu Ser Gln Gln Ile
                565                 570                 575     
Ser Thr Ala Gly Thr Glu Ala Ser Gly Thr Gly Asn Met Lys Phe Met
            580                 585                 590         
Leu Asn Gly Ala Leu Thr Ile Gly Thr Met Asp Gly Ala Asn Val Glu
        595                 600                 605             
Met Ala Glu Glu Ala Gly Ala Glu Asn Leu Phe Ile Phe Gly Leu Arg
    610                 615                 620                 
Val Glu Asp Val Glu Ala Leu Asp Arg Lys Gly Tyr Asn Ala Arg Glu
625                 630                 635                 640 
Tyr Tyr Asp His Leu Pro Glu Leu Lys Gln Ala Val Asp Gln Ile Ser
                645                 650                 655     
Ser Gly Phe Phe Ser Pro Lys Glu Pro Asp Cys Phe Lys Asp Ile Val
            660                 665                 670         
Asn Met Leu Met His His Asp Arg Phe Lys Val Phe Ala Asp Tyr Glu
        675                 680                 685             
Ala Tyr Met Gln Cys Gln Ala Gln Val Asp Gln Leu Tyr Arg Asn Pro
    690                 695                 700                 
Lys Glu Trp Thr Lys Lys Val Ile Arg Asn Ile Ala Cys Ser Gly Lys
705                 710                 715                 720 
Phe Ser Ser Asp Arg Thr Ile Thr Glu Tyr Ala Arg Glu Ile Trp Gly
                725                 730                 735     
Val Glu Pro Ser Asp Leu Gln Ile Pro Pro Pro Asn Ile Pro Arg Asp
            740                 745                 750         


<210> 1934
<211> 631
<212> PRT
<213> Homo sapiens

<400> 1934
Met Phe Gly His Gly Leu Lys His Leu Phe His Ser Arg Arg Arg Ser
 1               5                  10                  15      
Arg Glu Arg Glu His Gln Thr Ser Gln Asp Ser Gln Gln His Gln Gln
            20                  25                  30          
Gln Gln Gly Met Ser Asp His Asp Ser Pro Asp Glu Lys Glu Arg Ser
        35                  40                  45              
Pro Glu Met His Arg Val Ser Tyr Ala Met Ser Leu His Asp Leu Pro
    50                  55                  60                  
Ala Arg Pro Thr Ala Phe Asn Arg Val Leu Gln Gln Ile Arg Ser Arg
65                  70                  75                  80  
Pro Ser Ile Lys Arg Gly Ala Ser Leu His Ser Ser Ser Gly Gly Gly
                85                  90                  95      
Ser Ser Gly Ser Ser Ser Arg Arg Thr Lys Ser Ser Ser Leu Glu Pro
            100                 105                 110         
Gln Arg Gly Ser Pro His Leu Leu Arg Lys Ala Pro Gln Asp Ser Ser
        115                 120                 125             
Leu Ala Ala Ile Leu His Gln His Gln Cys Arg Pro Arg Ser Ser Ser
    130                 135                 140                 
Thr Thr Asp Thr Ala Leu Leu Leu Ala Asp Gly Ser Asn Val Tyr Leu
145                 150                 155                 160 
Leu Ala Glu Glu Ala Glu Gly Ile Gly Asp Lys Val Asp Lys Gly Asp
                165                 170                 175     
Leu Val Ala Leu Ser Leu Pro Ala Gly His Gly Asp Thr Asp Gly Pro
            180                 185                 190         
Ile Ser Leu Asp Val Pro Asp Gly Ala Pro Asp Pro Gln Arg Thr Lys
        195                 200                 205             
Ala Ala Ile Asp His Leu His Gln Lys Ile Leu Lys Ile Thr Glu Gln
    210                 215                 220                 
Ile Lys Ile Glu Gln Glu Ala Arg Asp Asp Asn Val Ala Glu Tyr Leu
225                 230                 235                 240 
Lys Leu Ala Asn Asn Ala Asp Lys Gln Gln Val Ser Arg Ile Lys Gln
                245                 250                 255     
Val Phe Glu Lys Lys Asn Gln Lys Ser Ala Gln Thr Ile Ala Gln Leu
            260                 265                 270         
His Lys Lys Leu Glu His Tyr Arg Arg Arg Leu Lys Glu Ile Glu Gln
        275                 280                 285             
Asn Gly Pro Ser Arg Gln Pro Lys Asp Val Leu Arg Asp Met Gln Gln
    290                 295                 300                 
Gly Leu Lys Asp Val Gly Ala Asn Val Arg Ala Gly Ile Ser Gly Phe
305                 310                 315                 320 
Gly Gly Gly Val Val Glu Gly Val Lys Gly Ser Leu Ser Gly Leu Ser
                325                 330                 335     
Gln Ala Thr His Thr Ala Val Val Ser Lys Pro Arg Glu Phe Ala Ser
            340                 345                 350         
Leu Ile Arg Asn Lys Phe Gly Ser Ala Asp Asn Ile Ala His Leu Lys
        355                 360                 365             
Asp Pro Leu Glu Asp Gly Pro Pro Glu Glu Ala Ala Arg Ala Leu Ser
    370                 375                 380                 
Gly Ser Ala Thr Leu Val Ser Ser Pro Lys Tyr Gly Ser Asp Asp Glu
385                 390                 395                 400 
Cys Ser Ser Ala Ser Ala Ser Ser Ala Gly Ala Gly Ser Asn Ser Gly
                405                 410                 415     
Ala Gly Pro Gly Gly Ala Leu Gly Ser Pro Lys Ser Asn Ala Leu Tyr
            420                 425                 430         
Gly Ala Pro Gly Asn Leu Asp Ala Leu Leu Glu Glu Leu Arg Glu Ile
        435                 440                 445             
Lys Glu Gly Gln Ser His Leu Glu Asp Ser Met Glu Asp Leu Lys Thr
    450                 455                 460                 
Gln Leu Gln Arg Asp Tyr Thr Tyr Met Thr Gln Cys Leu Gln Glu Glu
465                 470                 475                 480 
Arg Tyr Arg Tyr Glu Arg Leu Glu Glu Gln Leu Asn Asp Leu Thr Glu
                485                 490                 495     
Leu His Gln Asn Glu Met Thr Asn Leu Lys Gln Glu Leu Ala Ser Met
            500                 505                 510         
Glu Glu Lys Val Ala Tyr Gln Ser Tyr Glu Arg Ala Arg Asp Ile Gln
        515                 520                 525             
Glu Ala Val Glu Ser Cys Leu Thr Arg Val Thr Lys Leu Glu Leu Gln
    530                 535                 540                 
Gln Gln Gln Gln Gln Val Val Gln Leu Glu Gly Val Glu Asn Ala Asn
545                 550                 555                 560 
Ala Arg Ala Leu Leu Gly Lys Phe Ile Asn Val Ile Leu Ala Leu Met
                565                 570                 575     
Ala Val Leu Leu Val Phe Val Ser Thr Ile Ala Asn Phe Ile Thr Pro
            580                 585                 590         
Leu Met Lys Thr Arg Leu Arg Ile Thr Ser Thr Thr Leu Leu Val Leu
        595                 600                 605             
Val Leu Phe Leu Leu Trp Lys His Trp Asp Ser Leu Thr Tyr Leu Leu
    610                 615                 620                 
Glu His Val Leu Leu Pro Ser
625                 630     


<210> 1935
<211> 936
<212> PRT
<213> Homo sapiens

<400> 1935
Met Gly Val Pro Asn Ser Lys Arg Pro Tyr Ser Lys Asn Thr Arg Leu
 1               5                  10                  15      
Val Gln Ser Arg Pro Cys Trp Arg Ile His Gly Pro Pro Leu Ile Ile
            20                  25                  30          
Glu Gly Ser Glu Tyr Trp Phe Val Ala Asp Leu His Leu Asn Tyr Glu
        35                  40                  45              
Glu Ala Val Leu Tyr Cys Ala Ser Asn His Ser Phe Leu Ala Thr Ile
    50                  55                  60                  
Thr Ser Phe Val Gly Leu Lys Ala Ile Lys Asn Lys Ile Ala Asn Ile
65                  70                  75                  80  
Ser Gly Asp Gly Gln Lys Trp Trp Ile Arg Ile Ser Glu Trp Pro Ile
                85                  90                  95      
Asp Asp His Phe Thr Tyr Ser Arg Tyr Pro Trp His Arg Phe Pro Val
            100                 105                 110         
Thr Phe Gly Glu Glu Cys Leu Tyr Met Ser Ala Lys Thr Trp Leu Ile
        115                 120                 125             
Asp Leu Gly Lys Pro Thr Asp Cys Ser Thr Lys Leu Pro Phe Ile Cys
    130                 135                 140                 
Glu Lys Tyr Asn Val Ser Ser Leu Glu Lys Tyr Ser Pro Asp Ser Ala
145                 150                 155                 160 
Ala Lys Val Gln Cys Ser Glu Gln Trp Ile Pro Phe Gln Asn Lys Cys
                165                 170                 175     
Phe Leu Lys Ile Lys Pro Val Ser Leu Thr Phe Ser Gln Ala Ser Asp
            180                 185                 190         
Thr Cys His Ser Tyr Gly Gly Thr Leu Pro Ser Val Leu Ser Gln Ile
        195                 200                 205             
Glu Gln Asp Phe Ile Thr Ser Leu Leu Pro Asp Met Glu Ala Thr Leu
    210                 215                 220                 
Trp Ile Gly Leu Arg Trp Thr Ala Tyr Glu Lys Ile Asn Lys Trp Thr
225                 230                 235                 240 
Asp Asn Arg Glu Leu Thr Tyr Ser Asn Phe His Pro Leu Leu Val Ser
                245                 250                 255     
Gly Arg Leu Arg Ile Pro Glu Asn Phe Phe Glu Glu Glu Ser Arg Tyr
            260                 265                 270         
His Cys Ala Leu Ile Leu Asn Leu Gln Lys Ser Pro Phe Thr Gly Thr
        275                 280                 285             
Trp Asn Phe Thr Ser Cys Ser Glu Arg His Phe Val Ser Leu Cys Gln
    290                 295                 300                 
Lys Tyr Ser Glu Val Lys Ser Arg Gln Thr Leu Gln Asn Ala Ser Glu
305                 310                 315                 320 
Thr Val Lys Tyr Leu Asn Asn Leu Tyr Lys Ile Ile Pro Lys Thr Leu
                325                 330                 335     
Thr Trp His Ser Ala Lys Arg Glu Cys Leu Lys Ser Asn Met Gln Leu
            340                 345                 350         
Val Ser Ile Thr Asp Pro Tyr Gln Gln Ala Phe Leu Ser Val Gln Ala
        355                 360                 365             
Leu Leu His Asn Ser Ser Leu Trp Ile Gly Leu Phe Ser Gln Asp Asp
    370                 375                 380                 
Glu Leu Asn Phe Gly Trp Ser Asp Gly Lys Arg Leu His Phe Ser Arg
385                 390                 395                 400 
Trp Ala Glu Thr Asn Gly Gln Leu Glu Asp Cys Val Val Leu Asp Thr
                405                 410                 415     
Asp Gly Phe Trp Lys Thr Val Asp Cys Asn Asp Asn Gln Pro Gly Ala
            420                 425                 430         
Ile Cys Tyr Tyr Ser Gly Asn Glu Thr Glu Lys Glu Val Lys Pro Val
        435                 440                 445             
Asp Ser Val Lys Cys Pro Ser Pro Val Leu Asn Thr Pro Trp Ile Pro
    450                 455                 460                 
Phe Gln Asn Cys Cys Tyr Asn Phe Ile Ile Thr Lys Asn Arg His Met
465                 470                 475                 480 
Ala Thr Thr Gln Asp Glu Val His Thr Lys Cys Gln Lys Leu Asn Pro
                485                 490                 495     
Lys Ser His Ile Leu Ser Ile Arg Asp Glu Lys Glu Asn Asn Phe Val
            500                 505                 510         
Leu Glu Gln Leu Leu Tyr Phe Asn Tyr Met Ala Ser Trp Val Met Leu
        515                 520                 525             
Gly Ile Thr Tyr Arg Asn Lys Ser Leu Met Trp Phe Asp Lys Thr Pro
    530                 535                 540                 
Leu Ser Tyr Thr His Trp Arg Ala Gly Arg Pro Thr Ile Lys Asn Glu
545                 550                 555                 560 
Lys Phe Leu Ala Gly Leu Ser Thr Asp Gly Phe Trp Asp Ile Gln Thr
                565                 570                 575     
Phe Lys Val Ile Glu Glu Ala Val Tyr Phe His Gln His Ser Ile Leu
            580                 585                 590         
Ala Cys Lys Ile Glu Met Val Asp Tyr Lys Glu Glu Tyr Asn Thr Thr
        595                 600                 605             
Leu Pro Gln Phe Met Pro Tyr Glu Asp Gly Ile Tyr Ser Val Ile Gln
    610                 615                 620                 
Lys Lys Val Thr Trp Tyr Glu Ala Leu Asn Met Cys Ser Gln Ser Gly
625                 630                 635                 640 
Gly His Leu Ala Ser Val His Asn Gln Asn Gly Gln Leu Phe Leu Glu
                645                 650                 655     
Asp Ile Val Lys Arg Asp Gly Phe Pro Leu Trp Val Gly Leu Ser Ser
            660                 665                 670         
His Asp Gly Ser Glu Ser Ser Phe Glu Trp Ser Asp Gly Ser Thr Phe
        675                 680                 685             
Asp Tyr Ile Pro Trp Lys Gly Gln Thr Ser Pro Gly Asn Cys Val Leu
    690                 695                 700                 
Leu Asp Pro Lys Gly Thr Trp Lys His Glu Lys Cys Asn Ser Val Lys
705                 710                 715                 720 
Asp Gly Ala Ile Cys Tyr Lys Pro Thr Lys Ser Lys Lys Leu Ser Arg
                725                 730                 735     
Leu Thr Tyr Ser Ser Arg Cys Pro Ala Ala Lys Glu Asn Gly Ser Arg
            740                 745                 750         
Trp Ile Gln Tyr Lys Gly His Cys Tyr Lys Ser Asp Gln Ala Leu His
        755                 760                 765             
Ser Phe Ser Glu Ala Lys Lys Leu Cys Ser Lys His Asp His Ser Ala
    770                 775                 780                 
Thr Ile Val Ser Ile Lys Asp Glu Asp Glu Asn Lys Phe Val Ser Arg
785                 790                 795                 800 
Leu Met Arg Glu Asn Asn Asn Ile Thr Met Arg Val Trp Leu Gly Leu
                805                 810                 815     
Ser Gln His Ser Val Asp Gln Ser Trp Ser Trp Leu Asp Gly Ser Glu
            820                 825                 830         
Val Thr Phe Val Lys Trp Glu Asn Lys Ser Lys Ser Gly Val Gly Arg
        835                 840                 845             
Cys Ser Met Leu Ile Ala Ser Asn Glu Thr Trp Lys Lys Val Glu Cys
    850                 855                 860                 
Glu His Gly Phe Gly Arg Val Val Cys Lys Val Pro Leu Gly Pro Asp
865                 870                 875                 880 
Tyr Thr Ala Ile Ala Ile Ile Val Ala Thr Leu Ser Ile Leu Val Leu
                885                 890                 895     
Met Gly Gly Leu Ile Trp Phe Leu Phe Gln Arg His Arg Leu His Leu
            900                 905                 910         
Ala Gly Phe Ser Ser Val Arg Tyr Ala Gln Gly Val Asn Glu Asp Glu
        915                 920                 925             
Ile Met Leu Pro Ser Phe His Asp
    930                 935     


<210> 1936
<211> 191
<212> PRT
<213> Homo sapiens

<400> 1936
Met Gly Gln Val Ala Thr Asp Val Phe Asn Ser Lys Asn Leu Ala Val
 1               5                  10                  15      
Gln Ala Gln Lys Lys Ile Leu Gly Lys Met Val Ser Lys Ser Ile Ala
            20                  25                  30          
Thr Thr Leu Ile Asp Asp Thr Ser Ser Glu Val Leu Asp Glu Leu Tyr
        35                  40                  45              
Arg Val Thr Arg Glu Tyr Thr Gln Asn Lys Lys Glu Ala Glu Lys Ile
    50                  55                  60                  
Ile Lys Asn Leu Ile Lys Thr Val Ile Lys Leu Ala Ile Leu Tyr Arg
65                  70                  75                  80  
Asn Asn Gln Phe Asn Gln Asp Glu Leu Ala Leu Met Glu Lys Phe Lys
                85                  90                  95      
Lys Lys Val His Gln Leu Ala Met Thr Val Val Ser Phe His Gln Val
            100                 105                 110         
Asp Tyr Thr Phe Asp Arg Asn Val Leu Ser Arg Leu Leu Asn Glu Cys
        115                 120                 125             
Arg Glu Met Leu His Gln Ile Ile Gln Arg His Leu Thr Ala Lys Ser
    130                 135                 140                 
His Gly Arg Val Asn Asn Val Phe Asp His Phe Ser Asp Cys Glu Phe
145                 150                 155                 160 
Leu Ala Ala Leu Tyr Asn Pro Phe Gly Asn Phe Lys Pro His Leu Gln
                165                 170                 175     
Lys Leu Cys Asp Gly Ile Asn Lys Met Leu Asp Glu Glu Asn Ile
            180                 185                 190     


<210> 1937
<211> 269
<212> PRT
<213> Homo sapiens

<400> 1937
Met Tyr Arg Asn Pro Gly Pro Ser Gly Pro Gln Leu Arg Asp Phe Ser
 1               5                  10                  15      
Ser Ile Ile Gln Thr Cys Ser Gly Asn Ile Gln Arg Ile Ser Gln Ala
            20                  25                  30          
Thr Ala Gln Ile Lys Asn Leu Met Ser Gln Leu Gly Thr Lys Gln Asp
        35                  40                  45              
Ser Ser Lys Leu Gln Glu Asn Leu Gln Gln Leu Gln His Ser Thr Asn
    50                  55                  60                  
Gln Leu Ala Lys Glu Thr Asn Glu Leu Leu Lys Glu Leu Gly Ser Leu
65                  70                  75                  80  
Pro Leu Pro Leu Ser Thr Ser Glu Gln Arg Gln Gln Arg Leu Gln Lys
                85                  90                  95      
Glu Arg Leu Met Asn Asp Phe Ser Ala Ala Leu Asn Asn Phe Gln Ala
            100                 105                 110         
Val Gln Arg Arg Val Ser Glu Lys Glu Lys Glu Ser Ile Ala Arg Ala
        115                 120                 125             
Arg Ala Gly Ser Arg Leu Ser Ala Glu Glu Arg Gln Arg Glu Glu Gln
    130                 135                 140                 
Leu Val Ser Phe Asp Ser His Glu Glu Trp Asn Gln Met Gln Ser Gln
145                 150                 155                 160 
Glu Asp Glu Val Ala Ile Thr Glu Gln Asp Leu Glu Leu Ile Lys Glu
                165                 170                 175     
Arg Glu Thr Ala Ile Arg Gln Leu Glu Ala Asp Ile Leu Asp Val Asn
            180                 185                 190         
Gln Ile Phe Lys Asp Leu Ala Met Met Ile His Asp Gln Gly Asp Leu
        195                 200                 205             
Ile Asp Ser Ile Glu Ala Asn Val Glu Ser Ser Glu Val His Val Glu
    210                 215                 220                 
Arg Ala Thr Glu Gln Leu Gln Arg Ala Ala Tyr Tyr Gln Lys Lys Ser
225                 230                 235                 240 
Arg Lys Lys Met Cys Ile Leu Val Leu Val Leu Ser Val Ile Ile Leu
                245                 250                 255     
Ile Leu Gly Leu Ile Ile Trp Leu Val Tyr Lys Thr Lys
            260                 265                 


<210> 1938
<211> 189
<212> PRT
<213> Homo sapiens

<400> 1938
Met Ala Ser Lys Arg Ala Leu Val Ile Leu Ala Lys Gly Ala Glu Glu
 1               5                  10                  15      
Met Glu Thr Val Ile Pro Val Asp Val Met Arg Arg Ala Gly Ile Lys
            20                  25                  30          
Val Thr Val Ala Gly Leu Ala Gly Lys Asp Pro Val Gln Cys Ser Arg
        35                  40                  45              
Asp Val Val Ile Cys Pro Asp Ala Ser Leu Glu Asp Ala Lys Lys Glu
    50                  55                  60                  
Gly Pro Tyr Asp Val Val Val Leu Pro Gly Gly Asn Leu Gly Ala Gln
65                  70                  75                  80  
Asn Leu Ser Glu Ser Ala Ala Val Lys Glu Ile Leu Lys Glu Gln Glu
                85                  90                  95      
Asn Arg Lys Gly Leu Ile Ala Ala Ile Cys Ala Gly Pro Thr Ala Leu
            100                 105                 110         
Leu Ala His Glu Ile Gly Phe Gly Ser Lys Val Thr Thr His Pro Leu
        115                 120                 125             
Ala Lys Asp Lys Met Met Asn Gly Gly His Tyr Thr Tyr Ser Glu Asn
    130                 135                 140                 
Arg Val Glu Lys Asp Gly Leu Ile Leu Thr Ser Arg Gly Pro Gly Thr
145                 150                 155                 160 
Ser Phe Glu Phe Ala Leu Ala Ile Val Glu Ala Leu Asn Gly Lys Glu
                165                 170                 175     
Val Ala Ala Gln Val Lys Ala Pro Leu Val Leu Lys Asp
            180                 185                 


<210> 1939
<211> 292
<212> PRT
<213> Homo sapiens

<400> 1939
Met His Ser Asp Ala Ala Ala Val Asn Phe Gln Leu Asn Ser His Leu
 1               5                  10                  15      
Ser Thr Leu Ala Asn Ile His Lys Ile Tyr His Thr Leu Asn Lys Leu
            20                  25                  30          
Asn Leu Thr Glu Asp Ile Gly Gln Asp Asp His Gln Thr Gly Ser Leu
        35                  40                  45              
Arg Ser Cys Ser Ser Ser Asp Cys Phe Asn Lys Val Met Pro Pro Arg
    50                  55                  60                  
Lys Lys Arg Arg Pro Ala Ser Gly Asp Asp Leu Ser Ala Lys Lys Ser
65                  70                  75                  80  
Arg His Asp Ser Met Tyr Arg Lys Tyr Asp Ser Thr Arg Ile Lys Thr
                85                  90                  95      
Glu Glu Glu Ala Phe Ser Ser Lys Arg Cys Leu Glu Trp Phe Tyr Glu
            100                 105                 110         
Tyr Ala Gly Thr Asp Asp Val Val Gly Pro Glu Gly Met Glu Lys Phe
        115                 120                 125             
Cys Glu Asp Ile Gly Val Glu Pro Glu Asn Val Val Met Leu Val Leu
    130                 135                 140                 
Ala Trp Lys Leu Asp Ala Gln Asn Met Gly Tyr Phe Thr Leu Gln Glu
145                 150                 155                 160 
Trp Leu Lys Gly Met Thr Ser Leu Gln Cys Asp Thr Thr Glu Lys Leu
                165                 170                 175     
Arg Asn Thr Leu Asp Tyr Leu Arg Ser Phe Leu Asn Asp Ser Thr Asn
            180                 185                 190         
Phe Lys Leu Ile Tyr Arg Tyr Ala Phe Asp Phe Ala Arg Glu Lys Asp
        195                 200                 205             
Gln Arg Ser Leu Asp Ile Asn Thr Ala Lys Cys Met Leu Gly Leu Leu
    210                 215                 220                 
Leu Gly Lys Ile Trp Pro Leu Phe Pro Val Phe His Gln Phe Leu Glu
225                 230                 235                 240 
Gln Ser Lys Tyr Lys Val Ile Asn Lys Asp Gln Trp Cys Asn Val Leu
                245                 250                 255     
Glu Phe Ser Arg Thr Ile Asn Leu Asp Leu Ser Asn Tyr Asp Glu Asp
            260                 265                 270         
Gly Ala Trp Pro Val Leu Leu Asp Glu Phe Val Glu Trp Tyr Lys Asp
        275                 280                 285             
Lys Gln Met Ser
    290         


<210> 1940
<211> 425
<212> PRT
<213> Homo sapiens

<400> 1940
Met Ala Ala Gly Phe Gly Arg Cys Cys Arg Cys Ser Leu Gln Val Leu
 1               5                  10                  15      
Arg Ser Ile Ser Arg Phe His Trp Arg Ser Gln His Thr Lys Ala Asn
            20                  25                  30          
Arg Gln Arg Glu Pro Gly Leu Gly Phe Ser Phe Glu Phe Thr Glu Gln
        35                  40                  45              
Gln Lys Glu Phe Gln Ala Thr Ala Arg Lys Phe Ala Arg Glu Glu Ile
    50                  55                  60                  
Ile Pro Val Ala Ala Glu Tyr Asp Lys Thr Gly Glu Tyr Pro Val Pro
65                  70                  75                  80  
Leu Ile Arg Arg Ala Trp Glu Leu Gly Leu Met Asn Thr His Ile Pro
                85                  90                  95      
Glu Asn Cys Gly Gly Leu Gly Leu Gly Thr Phe Asp Ala Cys Leu Ile
            100                 105                 110         
Ser Glu Glu Leu Ala Tyr Gly Cys Thr Gly Val Gln Thr Ala Ile Glu
        115                 120                 125             
Gly Asn Ser Leu Gly Gln Met Pro Ile Ile Ile Ala Gly Asn Asp Gln
    130                 135                 140                 
Gln Lys Lys Lys Tyr Leu Gly Arg Met Thr Glu Glu Pro Leu Met Cys
145                 150                 155                 160 
Ala Tyr Cys Val Thr Glu Pro Gly Ala Gly Ser Asp Val Ala Gly Ile
                165                 170                 175     
Lys Thr Lys Ala Glu Lys Lys Gly Asp Glu Tyr Ile Ile Asn Gly Gln
            180                 185                 190         
Lys Met Trp Ile Thr Asn Gly Gly Lys Ala Asn Trp Tyr Phe Leu Leu
        195                 200                 205             
Ala Arg Ser Asp Pro Asp Pro Lys Ala Pro Ala Asn Lys Ala Phe Thr
    210                 215                 220                 
Gly Phe Ile Val Glu Ala Asp Thr Pro Gly Ile Gln Ile Gly Arg Lys
225                 230                 235                 240 
Glu Leu Asn Met Gly Gln Arg Cys Ser Asp Thr Arg Gly Ile Val Phe
                245                 250                 255     
Glu Asp Val Lys Val Pro Lys Glu Asn Val Leu Ile Gly Asp Gly Ala
            260                 265                 270         
Gly Phe Lys Val Ala Met Gly Ala Phe Asp Lys Thr Arg Pro Val Val
        275                 280                 285             
Ala Ala Gly Ala Val Gly Leu Ala Gln Arg Ala Leu Asp Glu Ala Thr
    290                 295                 300                 
Lys Tyr Ala Leu Glu Arg Lys Thr Phe Gly Lys Leu Leu Val Glu His
305                 310                 315                 320 
Gln Ala Ile Ser Phe Met Leu Ala Glu Met Ala Met Lys Val Glu Leu
                325                 330                 335     
Ala Arg Met Ser Tyr Gln Arg Ala Ala Trp Glu Val Asp Ser Gly Arg
            340                 345                 350         
Arg Asn Thr Tyr Tyr Ala Ser Ile Ala Lys Ala Phe Ala Gly Asp Ile
        355                 360                 365             
Ala Asn Gln Leu Ala Thr Asp Ala Val Gln Ile Leu Gly Gly Asn Gly
    370                 375                 380                 
Phe Asn Thr Glu Tyr Pro Val Glu Lys Leu Met Arg Asp Ala Lys Ile
385                 390                 395                 400 
Tyr Gln Ile Tyr Glu Gly Thr Ser Gln Ile Gln Arg Leu Ile Val Ala
                405                 410                 415     
Arg Glu His Ile Asp Lys Tyr Lys Asn
            420                 425 


<210> 1941
<211> 909
<212> PRT
<213> Homo sapiens

<400> 1941
Met Ser Glu Leu Leu Tyr His Leu Thr Arg Cys Gly Lys Thr Asp Asp
 1               5                  10                  15      
Leu Leu Tyr Gly Ile Ile Met Asn Phe Ser Trp Leu Tyr Thr Met Ile
            20                  25                  30          
Lys Ile Gly Gln Phe Asp Lys Val Leu Ser Asp Ile Glu Leu Ala Tyr
        35                  40                  45              
Asn Tyr Ser Gln Glu Lys Glu Leu Lys Phe Leu Ala Asn Thr Leu Arg
    50                  55                  60                  
Ser Ile Lys Asn Lys Val Thr Ala Phe Pro Gly Ser Leu Ser Ala Glu
65                  70                  75                  80  
Leu Gln Gln Arg Leu Leu Pro Val Val Ser Ser Leu Pro Lys Leu Arg
                85                  90                  95      
His Leu Leu Leu Glu Cys Asp Lys Asp Gly Pro Lys Tyr Cys Ser Ile
            100                 105                 110         
Val Pro Leu His Ser Ser Met Asp Val Thr Tyr Ser Pro Glu Arg Leu
        115                 120                 125             
Pro Leu Ser Ser Ser His Leu His Val Thr Glu Ile Leu Pro Thr Cys
    130                 135                 140                 
Asn Pro Ser Thr Val Leu Thr Ala Leu Glu Asn Gly Ser Ile Ser Thr
145                 150                 155                 160 
Trp Asp Val Glu Thr Arg Gln Leu Leu Arg Gln Ile Thr Thr Ala Gln
                165                 170                 175     
Ser Val Ile Leu Gly Met Lys Leu Thr Ser Asp Glu Lys Tyr Leu Val
            180                 185                 190         
Val Ala Thr Thr Asn Asn Thr Leu Leu Ile Tyr Asp Asn Val Asn Ser
        195                 200                 205             
Cys Leu Leu Ser Glu Val Glu Ile Lys Gly Thr Lys His Gly Ser Ser
    210                 215                 220                 
Ala Thr Tyr Ile Asn Gly Phe Thr Leu Ser Ala Asn His Ala Leu Ala
225                 230                 235                 240 
Trp Leu Glu Ala Ser Lys Asp Val Thr Val Ile Asp Leu Leu Tyr Gly
                245                 250                 255     
Trp Pro Leu Tyr Gln Phe His Cys Trp Tyr Glu Val Thr Cys Val Gln
            260                 265                 270         
Cys Ser Leu Asp Gly Leu Tyr Ala Phe Cys Gly Gln Tyr Leu Asn Thr
        275                 280                 285             
Thr Thr Ile Phe His Leu Gly Ser Gly Glu Lys Leu Cys Thr Val Thr
    290                 295                 300                 
Ser Glu Phe Ser Gly Gly Phe Val Lys Phe Leu Leu Ile Leu Asp Thr
305                 310                 315                 320 
Ala Gln Glu Met Val Met Val Asp Ser Glu Gly Ser Leu Ser Val Trp
                325                 330                 335     
Asn Thr Glu Asp Ile Ser Ser Pro Gln Leu Thr Asp Asp Phe Asp Cys
            340                 345                 350         
Arg Arg Glu Asp Ser Glu Val Val Ser Ile Glu Leu Ser Glu Asp Gln
        355                 360                 365             
Ser Ala Val Leu Ile Cys Lys Ala Leu Ser Ile Glu Leu Leu Asp Thr
    370                 375                 380                 
Gly Leu Trp Lys Val Ala Glu Lys Phe Arg Ala Lys His Asn Glu Arg
385                 390                 395                 400 
Phe Ile Ser Ala Val Leu Ser Lys Asn Gly Asp Cys Ile Ile Ala Thr
                405                 410                 415     
Met Glu Asn Thr Ser Ala Val Phe Phe Trp Arg Arg Asp Thr Gly Gln
            420                 425                 430         
Cys Met Ala Ser Leu Gln Glu Ile Ser Gly Ser Ile Val Lys Leu Val
        435                 440                 445             
Lys Ser Ser His His Asn Met Leu Leu Ser Leu Ser Thr Ser Gly Val
    450                 455                 460                 
Leu Ser Ile Trp Asp Ile Asp Ile Ile Thr Ala Met Ser Asn Ile Asp
465                 470                 475                 480 
Lys Thr Gly Lys Pro Ile Gln Ser Leu Leu Leu Pro Ala Arg Gly Glu
                485                 490                 495     
Ile Ile Tyr Ser Leu Asp Gly Ser Asp Cys Val His Lys Trp Asn Phe
            500                 505                 510         
Ser Ser Gly Phe Ile Glu Ala Val Phe Lys His Glu Gly Ile Val Glu
        515                 520                 525             
His Cys Val Leu Thr Ser Thr Gly Asp Ile Met Val Thr Ser Asp Asp
    530                 535                 540                 
Lys Ser Ser Gln Tyr Val Trp His Thr Ser Ser Gly Glu Asn Leu Phe
545                 550                 555                 560 
Arg Ile Asn Gly Gln Arg Ile Ser Gln Leu Leu Ile Thr His Asn Asp
                565                 570                 575     
Gln Phe Val Val Ser Leu Cys Glu Glu Asn Ala Ser Arg Val Trp Arg
            580                 585                 590         
Leu Ala Thr Gly His Arg Val Cys Asn Ile Leu Thr Thr Leu Gln Asn
        595                 600                 605             
Ala Phe Ile Thr Ser Ala Asn Thr Phe Val Val Gly Met Thr Lys Ser
    610                 615                 620                 
Lys Val Leu Ala Val Ser Leu Trp Thr Gly Ser Ile Thr Lys Lys Phe
625                 630                 635                 640 
Cys Cys Glu Asp Gly Thr Thr Ile Val Asn Phe Lys Leu Ile Pro Asp
                645                 650                 655     
Cys Pro Asp Ile Ile Val Phe Ile Thr Ser Ala Glu Thr Val Asn Ile
            660                 665                 670         
Trp Ser Leu Thr Asp Glu Val Ile Cys Arg Arg Val Gln Leu Pro Asn
        675                 680                 685             
Asn Phe Leu Lys Asn Leu Glu Asp Phe Glu Ile Ser Pro Asn Gly Lys
    690                 695                 700                 
Leu Gly Ile Ile Ala Arg Gly Asp Glu Asn Ile Asn Val Leu Asp Leu
705                 710                 715                 720 
Tyr Ser Gly Lys Leu Arg Val Val His Ala Ser Gly Ile Ile Trp Arg
                725                 730                 735     
Gln Arg Leu Ser Arg Asp Gly Arg Tyr Leu Val Tyr Ile Cys Phe Arg
            740                 745                 750         
Asn Gly Glu Glu Glu Asp Glu Asn Gly Ala Ile Phe Ser Leu Ile Val
        755                 760                 765             
Met Arg Leu Ala Asp Gly Lys Asn Ile Gly Ala Cys Ser Leu Tyr Lys
    770                 775                 780                 
Thr Pro Thr Phe Leu Ala Leu Ser Gln Arg His Leu Asn Ile Ile Val
785                 790                 795                 800 
Gly Phe Asp Asp Gly Ser Ile Gly Ile Tyr Thr Val Val Asp Arg Val
                805                 810                 815     
Asp Ala Ala Leu Lys Ile Lys Ile Ala Thr Ser Asn Ser Arg Gln Ile
            820                 825                 830         
Phe Asn Asn Ala Thr His Thr Ser Arg Pro Lys Cys Asn Ser Tyr Cys
        835                 840                 845             
Phe Lys Ile Ser Val Asp Cys Leu Trp Arg Glu Ser Thr Glu Val Phe
    850                 855                 860                 
Ala Arg Asp Ser Pro Ile Thr Val Ser Asp Ser Thr Glu Ser Asn Glu
865                 870                 875                 880 
Ala Thr Pro Ser Lys Lys His Asn Ser Cys Tyr Glu Arg Val Cys Ser
                885                 890                 895     
Ala Leu Glu Ala Arg Gly His Ser Tyr Ala Pro Asp Asn
            900                 905                 


<210> 1942
<211> 882
<212> PRT
<213> Homo sapiens

<400> 1942
Met Ser Lys Tyr Leu Tyr Ala Asp Ser Ser Lys Thr Glu Glu Glu Glu
 1               5                  10                  15      
Leu Asp Glu Ser Asn Pro Phe Tyr Glu Pro Lys Ser Thr Pro Pro Pro
            20                  25                  30          
Asn Asn Leu Val Asn Pro Val Gln Glu Leu Glu Thr Glu Arg Arg Val
        35                  40                  45              
Lys Arg Lys Ala Pro Ala Pro Pro Val Leu Ser Pro Lys Thr Gly Val
    50                  55                  60                  
Leu Asn Glu Asn Thr Val Ser Ala Gly Lys Asp Leu Ser Thr Ser Pro
65                  70                  75                  80  
Lys Pro Ser Pro Ile Pro Ser Pro Val Leu Gly Arg Lys Pro Asn Ala
                85                  90                  95      
Ser Gln Ser Leu Leu Val Trp Cys Lys Glu Val Thr Lys Asn Tyr Arg
            100                 105                 110         
Gly Val Lys Ile Thr Asn Phe Thr Thr Ser Trp Arg Asn Gly Leu Ser
        115                 120                 125             
Phe Cys Ala Ile Leu His His Phe Arg Pro Asp Leu Ile Asp Tyr Lys
    130                 135                 140                 
Ser Leu Asn Pro Gln Asp Ile Lys Glu Asn Asn Lys Lys Ala Tyr Asp
145                 150                 155                 160 
Gly Phe Ala Ser Ile Gly Ile Ser Arg Leu Leu Glu Pro Ser Asp Met
                165                 170                 175     
Val Leu Leu Ala Ile Pro Asp Lys Leu Thr Val Met Thr Tyr Leu Tyr
            180                 185                 190         
Gln Ile Arg Ala His Phe Ser Gly Gln Glu Leu Asn Val Val Gln Ile
        195                 200                 205             
Glu Glu Asn Ser Ser Lys Ser Thr Tyr Lys Val Gly Asn Tyr Glu Thr
    210                 215                 220                 
Asp Thr Asn Ser Ser Val Asp Gln Glu Lys Phe Tyr Ala Glu Leu Ser
225                 230                 235                 240 
Asp Leu Lys Arg Glu Pro Glu Leu Gln Gln Pro Ile Ser Gly Ala Val
                245                 250                 255     
Asp Phe Leu Ser Gln Asp Asp Ser Val Phe Val Asn Asp Ser Gly Val
            260                 265                 270         
Gly Glu Ser Glu Ser Glu His Gln Thr Pro Asp Asp His Leu Ser Pro
        275                 280                 285             
Ser Thr Ala Ser Pro Tyr Cys Arg Arg Thr Lys Ser Asp Thr Glu Pro
    290                 295                 300                 
Gln Lys Ser Gln Gln Ser Ser Gly Arg Thr Ser Gly Ser Asp Asp Pro
305                 310                 315                 320 
Gly Ile Cys Ser Asn Thr Asp Ser Thr Gln Ala Gln Val Leu Leu Gly
                325                 330                 335     
Lys Lys Arg Leu Leu Lys Ala Glu Thr Leu Glu Leu Ser Asp Leu Tyr
            340                 345                 350         
Val Ser Asp Lys Lys Lys Asp Met Ser Pro Pro Phe Ile Cys Glu Glu
        355                 360                 365             
Thr Asp Glu Gln Lys Leu Gln Thr Leu Asp Ile Gly Ser Asn Leu Glu
    370                 375                 380                 
Lys Glu Lys Leu Glu Asn Ser Arg Ser Leu Glu Cys Arg Ser Asp Pro
385                 390                 395                 400 
Glu Ser Pro Ile Lys Lys Thr Ser Leu Ser Pro Thr Ser Lys Leu Gly
                405                 410                 415     
Tyr Ser Tyr Ser Arg Asp Leu Asp Leu Ala Lys Lys Lys His Ala Ser
            420                 425                 430         
Leu Arg Gln Thr Glu Ser Asp Pro Asp Ala Asp Arg Thr Thr Leu Asn
        435                 440                 445             
His Ala Asp His Ser Ser Lys Ile Val Gln His Arg Leu Leu Ser Arg
    450                 455                 460                 
Gln Glu Glu Leu Lys Glu Arg Ala Arg Val Leu Leu Glu Gln Ala Arg
465                 470                 475                 480 
Arg Asp Ala Ala Leu Lys Ala Gly Asn Lys His Asn Thr Asn Thr Ala
                485                 490                 495     
Thr Pro Phe Cys Asn Arg Gln Leu Ser Asp Gln Gln Asp Glu Glu Arg
            500                 505                 510         
Arg Arg Gln Leu Arg Glu Arg Ala Arg Gln Leu Ile Ala Glu Ala Arg
        515                 520                 525             
Ser Gly Val Lys Met Ser Glu Leu Pro Ser Tyr Gly Glu Met Ala Ala
    530                 535                 540                 
Glu Lys Leu Lys Glu Arg Ser Lys Ala Ser Gly Asp Glu Asn Asp Asn
545                 550                 555                 560 
Ile Glu Ile Asp Thr Asn Glu Glu Ile Pro Glu Gly Phe Val Val Gly
                565                 570                 575     
Gly Gly Asp Glu Leu Thr Asn Leu Glu Asn Asp Leu Asp Thr Pro Glu
            580                 585                 590         
Gln Asn Ser Lys Leu Val Asp Leu Lys Leu Lys Lys Leu Leu Glu Val
        595                 600                 605             
Gln Pro Gln Val Ala Asn Ser Pro Ser Ser Ala Ala Gln Lys Ala Val
    610                 615                 620                 
Thr Glu Ser Ser Glu Gln Asp Met Lys Ser Gly Thr Glu Asp Leu Arg
625                 630                 635                 640 
Thr Glu Arg Leu Gln Lys Thr Thr Glu Arg Phe Arg Asn Pro Val Val
                645                 650                 655     
Phe Ser Lys Asp Ser Thr Val Arg Lys Thr Gln Leu Gln Ser Phe Ser
            660                 665                 670         
Gln Tyr Ile Glu Asn Arg Pro Glu Met Lys Arg Gln Arg Ser Ile Gln
        675                 680                 685             
Glu Asp Thr Lys Lys Gly Asn Glu Glu Lys Ala Ala Ile Thr Glu Thr
    690                 695                 700                 
Gln Arg Lys Pro Ser Glu Asp Glu Val Leu Asn Lys Gly Phe Lys Asp
705                 710                 715                 720 
Thr Ser Gln Tyr Val Val Gly Glu Leu Ala Ala Leu Glu Asn Glu Gln
                725                 730                 735     
Lys Gln Ile Asp Thr Arg Ala Ala Leu Val Glu Lys Arg Leu Arg Tyr
            740                 745                 750         
Leu Met Asp Thr Gly Arg Asn Thr Glu Glu Glu Glu Ala Met Met Gln
        755                 760                 765             
Glu Trp Phe Met Leu Val Asn Lys Lys Asn Ala Leu Ile Arg Arg Met
    770                 775                 780                 
Asn Gln Leu Ser Leu Leu Glu Lys Glu His Asp Leu Glu Arg Arg Tyr
785                 790                 795                 800 
Glu Leu Leu Asn Arg Glu Leu Arg Ala Met Leu Ala Ile Glu Asp Trp
                805                 810                 815     
Gln Lys Thr Glu Ala Gln Lys Arg Arg Glu Gln Leu Leu Leu Asp Glu
            820                 825                 830         
Leu Val Ala Leu Val Asn Lys Arg Asp Ala Leu Val Arg Asp Leu Asp
        835                 840                 845             
Ala Gln Glu Lys Gln Ala Glu Glu Glu Asp Glu His Leu Glu Arg Thr
    850                 855                 860                 
Leu Glu Gln Asn Lys Gly Lys Met Ala Lys Lys Glu Glu Lys Cys Val
865                 870                 875                 880 
Leu Gln
        


<210> 1943
<211> 248
<212> PRT
<213> Homo sapiens

<400> 1943
Met Glu Gly Val Glu Glu Lys Lys Lys Glu Val Pro Ala Val Pro Glu
 1               5                  10                  15      
Thr Leu Lys Lys Lys Arg Arg Asn Phe Ala Glu Leu Lys Met Lys Arg
            20                  25                  30          
Leu Arg Lys Lys Phe Ala Gln Lys Met Leu Arg Lys Ala Arg Arg Lys
        35                  40                  45              
Leu Ile Tyr Glu Lys Ala Lys His Tyr His Lys Glu Tyr Arg Gln Met
    50                  55                  60                  
Tyr Arg Thr Glu Ile Arg Met Ala Arg Met Ala Arg Lys Ala Gly Asn
65                  70                  75                  80  
Phe Tyr Val Pro Ala Glu Pro Lys Leu Ala Phe Val Ile Arg Ile Arg
                85                  90                  95      
Gly Ile Asn Gly Val Ser Pro Lys Val Arg Lys Val Leu Gln Leu Leu
            100                 105                 110         
Arg Leu Arg Gln Ile Phe Asn Gly Thr Phe Val Lys Leu Asn Lys Ala
        115                 120                 125             
Ser Ile Asn Met Leu Arg Ile Val Glu Pro Tyr Ile Ala Trp Gly Tyr
    130                 135                 140                 
Pro Asn Leu Lys Ser Val Asn Glu Leu Ile Tyr Lys Arg Gly Tyr Gly
145                 150                 155                 160 
Lys Ile Asn Lys Lys Arg Ile Ala Leu Thr Asp Asn Ala Leu Ile Ala
                165                 170                 175     
Arg Ser Leu Gly Lys Tyr Gly Ile Ile Cys Val Glu Asp Leu Ile His
            180                 185                 190         
Glu Ile Tyr Thr Val Gly Lys Arg Phe Lys Glu Ala Asn Asn Phe Leu
        195                 200                 205             
Trp Pro Phe Lys Leu Ser Ser Pro Arg Gly Gly Met Lys Lys Lys Thr
    210                 215                 220                 
Thr His Phe Val Glu Gly Gly Asp Ala Gly Asn Arg Glu Asp Gln Ile
225                 230                 235                 240 
Asn Arg Leu Ile Arg Arg Met Asn
                245             


<210> 1944
<211> 1494
<212> PRT
<213> Homo sapiens

<400> 1944
Met Asn Gly Gly Lys Glu Cys Asp Gly Gly Asp Lys Glu Gly Gly Leu
 1               5                  10                  15      
Pro Ala Ile Gln Val Pro Val Gly Trp Gln Arg Arg Val Asp Gln Asn
            20                  25                  30          
Gly Val Leu Tyr Val Ser Pro Ser Gly Ser Leu Leu Ser Cys Leu Glu
        35                  40                  45              
Gln Val Lys Thr Tyr Leu Leu Thr Asp Gly Thr Cys Lys Cys Gly Leu
    50                  55                  60                  
Glu Cys Pro Leu Ile Leu Pro Lys Val Phe Asn Phe Asp Pro Gly Ala
65                  70                  75                  80  
Ala Val Lys Gln Arg Thr Ala Glu Asp Val Lys Ala Asp Glu Asp Val
                85                  90                  95      
Thr Lys Leu Cys Ile His Lys Arg Lys Ile Ile Ala Val Ala Thr Leu
            100                 105                 110         
His Lys Ser Met Glu Ala Pro His Pro Ser Leu Val Leu Thr Ser Pro
        115                 120                 125             
Gly Gly Gly Thr Asn Ala Thr Pro Val Val Pro Ser Arg Ala Ala Thr
    130                 135                 140                 
Pro Arg Ser Val Arg Asn Lys Ser His Glu Gly Ile Thr Asn Ser Val
145                 150                 155                 160 
Met Pro Glu Cys Lys Asn Pro Phe Lys Leu Met Ile Gly Ser Ser Asn
                165                 170                 175     
Ala Met Gly Arg Leu Tyr Val Gln Glu Leu Pro Gly Ser Gln Gln Gln
            180                 185                 190         
Glu Leu His Pro Val Tyr Pro Arg Gln Arg Leu Gly Ser Ser Glu His
        195                 200                 205             
Gly Gln Lys Ser Pro Phe Arg Gly Ser His Gly Gly Leu Pro Ser Pro
    210                 215                 220                 
Ala Ser Ser Gly Ser Gln Ile Tyr Gly Asp Gly Ser Ile Ser Pro Arg
225                 230                 235                 240 
Thr Asp Pro Leu Gly Ser Pro Asp Val Phe Thr Arg Ser Asn Pro Gly
                245                 250                 255     
Phe His Gly Ala Pro Asn Ser Ser Pro Ile His Leu Asn Arg Thr Pro
            260                 265                 270         
Leu Ser Pro Pro Ser Val Met Leu His Gly Ser Pro Val Gln Ser Ser
        275                 280                 285             
Cys Ala Met Ala Gly Arg Thr Asn Ile Pro Leu Ser Pro Thr Leu Thr
    290                 295                 300                 
Thr Lys Ser Pro Val Met Lys Lys Pro Met Cys Asn Phe Ser Thr Asn
305                 310                 315                 320 
Met Glu Ile Pro Arg Ala Met Phe His His Lys Pro Pro Gln Gly Pro
                325                 330                 335     
Pro Pro Pro Pro Pro Pro Ser Cys Ala Leu Gln Lys Lys Pro Leu Thr
            340                 345                 350         
Ser Glu Lys Asp Pro Leu Gly Ile Leu Asp Pro Ile Pro Ser Lys Pro
        355                 360                 365             
Val Asn Gln Asn Pro Val Ile Ile Asn Pro Thr Ser Phe His Ser Asn
    370                 375                 380                 
Val His Ser Gln Val Pro Met Met Asn Val Ser Met Pro Pro Ala Val
385                 390                 395                 400 
Val Pro Leu Pro Ser Asn Leu Pro Leu Pro Thr Val Lys Pro Gly His
                405                 410                 415     
Met Asn His Gly Ser His Val Gln Arg Val Gln His Ser Ala Ser Thr
            420                 425                 430         
Ser Leu Ser Pro Ser Pro Val Thr Ser Pro Val His Met Met Gly Thr
        435                 440                 445             
Gly Ile Gly Arg Ile Glu Ala Ser Pro Gln Arg Ser Arg Ser Ser Ser
    450                 455                 460                 
Thr Ser Ser Asp His Gly Asn Phe Met Met Pro Pro Val Gly Pro Gln
465                 470                 475                 480 
Ala Thr Ser Ser Gly Ile Lys Val Pro Pro Arg Ser Pro Arg Ser Thr
                485                 490                 495     
Ile Gly Ser Pro Arg Pro Ser Met Pro Ser Ser Pro Ser Thr Lys Ser
            500                 505                 510         
Asp Gly His His Gln Tyr Lys Asp Ile Pro Asn Pro Leu Ile Ala Gly
        515                 520                 525             
Ile Ser Asn Val Leu Asn Thr Pro Ser Ser Ala Ala Phe Pro Thr Ala
    530                 535                 540                 
Ser Ala Gly Ser Ser Ser Val Lys Ser Gln Pro Gly Leu Leu Gly Met
545                 550                 555                 560 
Pro Leu Asn Gln Ile Leu Asn Gln His Asn Ala Ala Ser Phe Pro Ala
                565                 570                 575     
Ser Ser Leu Leu Ser Ala Ala Ala Lys Ala Gln Leu Ala Asn Gln Asn
            580                 585                 590         
Lys Leu Ala Gly Asn Asn Ser Ser Ser Ser Ser Asn Ser Gly Ala Val
        595                 600                 605             
Ala Gly Ser Gly Asn Thr Glu Gly His Ser Thr Leu Asn Thr Met Phe
    610                 615                 620                 
Pro Pro Thr Ala Asn Met Leu Leu Pro Thr Gly Glu Gly Gln Ser Gly
625                 630                 635                 640 
Arg Ala Ala Leu Arg Asp Lys Leu Met Ser Gln Gln Lys Asp Ala Leu
                645                 650                 655     
Arg Lys Arg Lys Gln Pro Pro Thr Thr Val Leu Ser Leu Leu Arg Gln
            660                 665                 670         
Ser Gln Met Asp Ser Ser Ala Val Pro Lys Pro Gly Pro Asp Leu Leu
        675                 680                 685             
Arg Lys Gln Gly Gln Gly Ser Phe Pro Ile Ser Ser Met Ser Gln Leu
    690                 695                 700                 
Leu Gln Ser Met Ser Cys Gln Ser Ser His Leu Ser Ser Asn Ser Thr
705                 710                 715                 720 
Pro Gly Cys Gly Ala Ser Asn Thr Ala Leu Pro Cys Ser Ala Asn Gln
                725                 730                 735     
Leu His Phe Thr Asp Pro Ser Met Asn Ser Ser Val Leu Gln Asn Ile
            740                 745                 750         
Pro Leu Arg Gly Glu Ala Val His Cys His Asn Ala Asn Thr Asn Phe
        755                 760                 765             
Val His Ser Asn Ser Pro Val Pro Asn His His Leu Ala Gly Leu Ile
    770                 775                 780                 
Asn Gln Ile Gln Ala Ser Gly Asn Cys Gly Met Leu Ser Gln Ser Gly
785                 790                 795                 800 
Met Ala Leu Gly Asn Ser Leu His Pro Asn Pro Pro Gln Ser Arg Ile
                805                 810                 815     
Ser Thr Ser Ser Thr Pro Val Ile Pro Asn Ser Ile Val Ser Ser Tyr
            820                 825                 830         
Asn Gln Thr Ser Ser Glu Ala Gly Gly Ser Gly Pro Ser Ser Ser Ile
        835                 840                 845             
Ala Ile Ala Gly Thr Asn His Pro Ala Ile Thr Lys Thr Thr Ser Val
    850                 855                 860                 
Leu Gln Asp Gly Val Ile Val Thr Thr Ala Ala Gly Asn Pro Leu Gln
865                 870                 875                 880 
Ser Gln Leu Pro Ile Gly Ser Asp Phe Pro Phe Val Gly Gln Glu His
                885                 890                 895     
Ala Leu His Phe Pro Ser Asn Ser Thr Ser Asn Asn His Leu Pro His
            900                 905                 910         
Pro Leu Asn Pro Ser Leu Leu Ser Ser Leu Pro Ile Ser Leu Pro Val
        915                 920                 925             
Asn Gln Gln His Leu Leu Asn Gln Asn Leu Leu Asn Ile Leu Gln Pro
    930                 935                 940                 
Ser Ala Gly Glu Gly Asp Met Ser Ser Ile Asn Asn Thr Leu Ser Asn
945                 950                 955                 960 
His Gln Leu Thr His Leu Gln Ser Leu Leu Asn Asn Asn Gln Met Phe
                965                 970                 975     
Pro Pro Asn Gln Gln Gln Gln Gln Leu Leu Gln Gly Tyr Gln Asn Leu
            980                 985                 990         
Gln Ala Phe Gln Gly Gln Ser Thr Ile Pro Cys Pro Ala Asn Asn Asn
        995                 1000                1005            
Pro Met Ala Cys Leu Phe Gln Asn Phe Gln Val Arg Met Gln Glu Asp
    1010                1015                1020                
Ala Ala Leu Leu Asn Lys Arg Ile Ser Thr Gln Pro Gly Leu Thr Ala
1025                1030                1035                1040
Leu Pro Glu Asn Pro Asn Thr Thr Leu Pro Pro Phe Gln Asp Thr Pro
                1045                1050                1055    
Cys Glu Leu Gln Pro Arg Ile Asp Pro Ser Leu Gly Gln Gln Val Lys
            1060                1065                1070        
Asp Gly Leu Val Val Gly Gly Pro Gly Asp Ala Ser Val Asp Ala Ile
        1075                1080                1085            
Tyr Lys Ala Val Val Asp Ala Ala Ser Lys Gly Met Gln Val Val Ile
    1090                1095                1100                
Thr Thr Ala Val Asn Ser Thr Thr Gln Ile Ser Pro Ile Pro Ala Leu
1105                1110                1115                1120
Ser Ala Met Ser Ala Phe Thr Ala Ser Ile Gly Asp Pro Leu Asn Leu
                1125                1130                1135    
Ser Ser Ala Val Ser Ala Val Ile His Gly Arg Asn Met Gly Gly Val
            1140                1145                1150        
Asp His Asp Gly Arg Leu Arg Asn Ser Arg Gly Ala Arg Leu Pro Lys
        1155                1160                1165            
Asn Leu Asp His Gly Lys Asn Val Asn Glu Gly Asp Gly Phe Glu Tyr
    1170                1175                1180                
Phe Lys Ser Ala Ser Cys His Thr Ser Lys Lys Gln Trp Asp Gly Glu
1185                1190                1195                1200
Gln Ser Pro Arg Gly Glu Arg Asn Arg Trp Lys Tyr Glu Glu Phe Leu
                1205                1210                1215    
Asp His Pro Gly His Ile His Ser Ser Pro Cys His Glu Arg Pro Asn
            1220                1225                1230        
Asn Val Ser Thr Leu Pro Phe Leu Pro Gly Glu Gln His Pro Ile Leu
        1235                1240                1245            
Leu Pro Pro Arg Asn Cys Pro Gly Asp Lys Ile Leu Glu Glu Asn Phe
    1250                1255                1260                
Arg Tyr Asn Asn Tyr Lys Arg Thr Met Met Ser Phe Lys Glu Arg Leu
1265                1270                1275                1280
Glu Asn Thr Val Glu Arg Cys Ala His Ile Asn Gly Asn Arg Pro Arg
                1285                1290                1295    
Gln Ser Arg Gly Phe Gly Glu Leu Leu Ser Thr Ala Lys Gln Asp Leu
            1300                1305                1310        
Val Leu Glu Glu Gln Ser Pro Ser Ser Ser Asn Ser Leu Glu Asn Ser
        1315                1320                1325            
Leu Val Lys Asp Tyr Ile His Tyr Asn Gly Asp Phe Asn Ala Lys Ser
    1330                1335                1340                
Val Asn Gly Cys Val Pro Ser Pro Ser Asp Ala Lys Ser Ile Ser Ser
1345                1350                1355                1360
Glu Asp Asp Leu Arg Asn Pro Asp Ser Pro Ser Ser Asn Glu Leu Ile
                1365                1370                1375    
His Tyr Arg Pro Arg Thr Phe Asn Val Gly Asp Leu Val Trp Gly Gln
            1380                1385                1390        
Ile Lys Gly Leu Thr Ser Trp Pro Gly Lys Leu Val Arg Glu Asp Asp
        1395                1400                1405            
Val His Asn Ser Cys Gln Gln Ser Pro Glu Glu Gly Lys Val Glu Pro
    1410                1415                1420                
Glu Lys Leu Lys Thr Leu Thr Glu Gly Leu Glu Ala Tyr Ser Arg Val
1425                1430                1435                1440
Arg Lys Arg Asn Arg Lys Ser Gly Lys Leu Asn Asn His Leu Glu Ala
                1445                1450                1455    
Ala Ile His Glu Ala Met Ser Glu Leu Asp Lys Met Ser Gly Thr Val
            1460                1465                1470        
His Gln Ile Pro Gln Gly Asp Arg Gln Met Arg Pro Pro Lys Pro Lys
        1475                1480                1485            
Arg Arg Lys Ile Ser Arg
    1490                


<210> 1945
<211> 600
<212> PRT
<213> Homo sapiens

<400> 1945
Met Leu Ser Gly Lys Lys Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala
 1               5                  10                  15      
Ala Ala Thr Gly Thr Glu Ala Gly Pro Gly Thr Ala Gly Gly Ser Glu
            20                  25                  30          
Asn Gly Ser Glu Val Ala Ala Gln Pro Ala Gly Leu Ser Gly Pro Ala
        35                  40                  45              
Glu Val Gly Pro Gly Ala Val Gly Glu Arg Thr Pro Arg Lys Lys Glu
    50                  55                  60                  
Pro Pro Arg Ala Ser Pro Pro Gly Gly Leu Ala Glu Pro Pro Gly Ser
65                  70                  75                  80  
Ala Gly Pro Gln Ala Gly Pro Thr Val Val Pro Gly Ser Ala Thr Pro
                85                  90                  95      
Met Glu Thr Gly Ile Ala Glu Thr Pro Glu Gly Arg Arg Thr Ser Arg
            100                 105                 110         
Arg Lys Arg Ala Lys Val Glu Tyr Arg Glu Met Asp Glu Ser Leu Ala
        115                 120                 125             
Asn Leu Ser Glu Asp Glu Tyr Tyr Ser Glu Glu Glu Arg Asn Ala Lys
    130                 135                 140                 
Ala Glu Lys Glu Lys Lys Leu Pro Pro Pro Pro Pro Gln Ala Pro Pro
145                 150                 155                 160 
Glu Glu Glu Asn Glu Ser Glu Pro Glu Glu Pro Ser Gly Val Glu Gly
                165                 170                 175     
Ala Ala Phe Gln Ser Arg Leu Pro His Asp Arg Met Thr Ser Gln Glu
            180                 185                 190         
Ala Ala Cys Phe Pro Asp Ile Ile Ser Gly Pro Gln Gln Thr Gln Lys
        195                 200                 205             
Val Phe Leu Phe Ile Arg Asn Arg Thr Leu Gln Leu Trp Leu Asp Asn
    210                 215                 220                 
Pro Lys Ile Gln Leu Thr Phe Glu Ala Thr Leu Gln Gln Leu Glu Ala
225                 230                 235                 240 
Pro Tyr Asn Ser Asp Thr Val Leu Val His Arg Val His Ser Tyr Leu
                245                 250                 255     
Glu Arg His Gly Leu Ile Asn Phe Gly Ile Tyr Lys Arg Ile Lys Pro
            260                 265                 270         
Leu Pro Thr Lys Lys Thr Gly Lys Val Ile Ile Ile Gly Ser Gly Val
        275                 280                 285             
Ser Gly Leu Ala Ala Ala Arg Gln Leu Gln Ser Phe Gly Met Asp Val
    290                 295                 300                 
Thr Leu Leu Glu Ala Arg Asp Arg Val Gly Gly Arg Val Ala Thr Phe
305                 310                 315                 320 
Arg Lys Gly Asn Tyr Val Ala Asp Leu Gly Ala Met Val Val Thr Gly
                325                 330                 335     
Leu Gly Gly Asn Pro Met Ala Val Val Ser Lys Gln Val Asn Met Glu
            340                 345                 350         
Leu Ala Lys Ile Lys Gln Lys Cys Pro Leu Tyr Glu Ala Asn Gly Gln
        355                 360                 365             
Ala Val Pro Lys Glu Lys Asp Glu Met Val Glu Gln Glu Phe Asn Arg
    370                 375                 380                 
Leu Leu Glu Ala Thr Ser Tyr Leu Ser His Gln Leu Asp Phe Asn Val
385                 390                 395                 400 
Leu Asn Asn Lys Pro Val Ser Leu Gly Gln Ala Leu Glu Val Val Ile
                405                 410                 415     
Gln Leu Gln Glu Lys His Val Lys Asp Glu Gln Ile Glu His Trp Lys
            420                 425                 430         
Lys Ile Val Lys Thr Gln Glu Glu Leu Lys Glu Leu Leu Asn Lys Met
        435                 440                 445             
Val Asn Leu Lys Glu Lys Ile Lys Glu Leu His Gln Gln Tyr Lys Glu
    450                 455                 460                 
Ala Ser Glu Val Lys Pro Pro Arg Asp Ile Thr Ala Glu Phe Leu Val
465                 470                 475                 480 
Lys Ser Lys His Arg Asp Leu Thr Ala Leu Cys Lys Glu Tyr Asp Glu
                485                 490                 495     
Leu Ala Glu Thr Gln Gly Lys Leu Glu Glu Lys Leu Gln Glu Leu Glu
            500                 505                 510         
Ala Asn Pro Pro Ser Asp Val Tyr Leu Ser Ser Arg Asp Arg Gln Ile
        515                 520                 525             
Leu Asp Trp His Phe Ala Asn Leu Glu Phe Ala Asn Ala Thr Pro Leu
    530                 535                 540                 
Ser Thr Leu Ser Leu Lys His Trp Asp Gln Asp Asp Asp Phe Glu Phe
545                 550                 555                 560 
Thr Gly Ser His Leu Thr Val Arg Asn Gly Tyr Ser Cys Val Pro Val
                565                 570                 575     
Ala Leu Ala Glu Gly Leu Asp Ile Lys Leu Asn Thr Ala Val Arg Gln
            580                 585                 590         
Val Arg Tyr Thr Ala Ser Gly Met
        595                 600 


<210> 1946
<211> 638
<212> PRT
<213> Homo sapiens

<400> 1946
Met Asn Val Lys Ile Pro Glu Asn Ile Tyr Arg Gly Ile Arg Asn Leu
 1               5                  10                  15      
Leu Glu Ser Tyr His Val Pro Glu Leu Ile Lys Asp Ala His Leu Leu
            20                  25                  30          
Val Glu Ser Lys Asn Leu Asp Phe Gln Lys Thr Val Gln Leu Thr Ser
        35                  40                  45              
Ser Glu Leu Glu Ser Thr Leu Glu Thr Leu Lys Ala Glu Asn Gln Pro
    50                  55                  60                  
Ile Arg Asp Val Leu Lys Gln Leu Ile Leu Val Leu Cys Ser Glu Glu
65                  70                  75                  80  
Asn Met Gln Lys Ala Leu Glu Leu Lys Ala Lys Tyr Glu Ser Asp Met
                85                  90                  95      
Val Thr Gly Gly Tyr Ala Ala Leu Ile Asn Leu Cys Cys Arg His Asp
            100                 105                 110         
Lys Val Glu Asp Ala Leu Asn Leu Lys Glu Glu Phe Asp Arg Leu Asp
        115                 120                 125             
Ser Ser Ala Val Leu Asp Thr Gly Lys Tyr Val Gly Leu Val Arg Val
    130                 135                 140                 
Leu Ala Lys His Gly Lys Leu Gln Asp Ala Ile Asn Ile Leu Lys Glu
145                 150                 155                 160 
Met Lys Glu Lys Asp Val Leu Ile Lys Asp Thr Thr Ala Leu Ser Phe
                165                 170                 175     
Phe His Met Leu Asn Gly Ala Ala Leu Arg Gly Glu Ile Glu Thr Val
            180                 185                 190         
Lys Gln Leu His Glu Ala Ile Val Thr Leu Gly Leu Ala Glu Pro Ser
        195                 200                 205             
Thr Asn Ile Ser Phe Pro Leu Val Thr Val His Leu Glu Lys Gly Asp
    210                 215                 220                 
Leu Ser Thr Ala Leu Glu Val Ala Ile Asp Cys Tyr Glu Lys Tyr Lys
225                 230                 235                 240 
Val Leu Pro Arg Ile His Asp Val Leu Cys Lys Leu Val Glu Lys Gly
                245                 250                 255     
Glu Thr Asp Leu Ile Gln Lys Ala Met Asp Phe Val Ser Gln Glu Gln
            260                 265                 270         
Gly Glu Met Val Met Leu Tyr Asp Leu Phe Phe Ala Phe Leu Gln Thr
        275                 280                 285             
Gly Asn Tyr Lys Glu Ala Lys Lys Ile Ile Glu Thr Pro Gly Ile Arg
    290                 295                 300                 
Ala Arg Ser Ala Arg Leu Gln Trp Phe Cys Asp Arg Cys Val Ala Asn
305                 310                 315                 320 
Asn Gln Val Glu Thr Leu Glu Lys Leu Val Glu Leu Thr Gln Lys Leu
                325                 330                 335     
Phe Glu Cys Asp Arg Asp Gln Met Tyr Tyr Asn Leu Leu Lys Leu Tyr
            340                 345                 350         
Lys Ile Asn Gly Asp Trp Gln Arg Ala Asp Ala Val Trp Asn Lys Ile
        355                 360                 365             
Gln Glu Glu Asn Val Ile Pro Arg Glu Lys Thr Leu Arg Leu Leu Ala
    370                 375                 380                 
Glu Ile Leu Arg Glu Gly Asn Gln Glu Val Pro Phe Asp Val Pro Glu
385                 390                 395                 400 
Leu Trp Tyr Glu Asp Glu Lys His Ser Leu Asn Ser Ser Ser Ala Ser
                405                 410                 415     
Thr Thr Glu Pro Asp Phe Gln Lys Asp Ile Leu Ile Ala Cys Arg Leu
            420                 425                 430         
Asn Gln Lys Lys Gly Ala Tyr Asp Ile Phe Leu Asn Ala Lys Glu Gln
        435                 440                 445             
Asn Ile Val Phe Asn Ala Glu Thr Tyr Ser Asn Leu Ile Lys Leu Leu
    450                 455                 460                 
Met Ser Glu Asp Tyr Phe Thr Gln Ala Met Glu Val Lys Ala Phe Ala
465                 470                 475                 480 
Glu Thr His Ile Lys Gly Phe Thr Leu Asn Asp Ala Ala Asn Ser Arg
                485                 490                 495     
Leu Ile Ile Thr Gln Val Arg Arg Asp Tyr Leu Lys Glu Ala Val Thr
            500                 505                 510         
Thr Leu Lys Thr Val Leu Asp Gln Gln Gln Thr Pro Ser Arg Leu Ala
        515                 520                 525             
Val Thr Arg Val Ile Gln Ala Leu Ala Met Lys Gly Asp Val Glu Asn
    530                 535                 540                 
Ile Glu Val Val Gln Lys Met Leu Asn Gly Leu Glu Asp Ser Ile Gly
545                 550                 555                 560 
Leu Ser Lys Met Val Phe Ile Asn Asn Ile Ala Leu Ala Gln Ile Lys
                565                 570                 575     
Asn Asn Asn Ile Asp Ala Ala Ile Glu Asn Ile Glu Asn Met Leu Thr
            580                 585                 590         
Ser Glu Asn Lys Val Ile Glu Pro Gln Tyr Phe Gly Leu Ala Tyr Leu
        595                 600                 605             
Phe Arg Lys Val Ile Glu Glu Gln Leu Glu Pro Ala Val Glu Lys Ser
    610                 615                 620                 
Lys His His Gly Gly Glu Ile Gly Gln Ser Val Cys Asn Leu
625                 630                 635             


<210> 1947
<211> 159
<212> PRT
<213> Homo sapiens

<400> 1947
Met Ala Val Pro Trp Arg Leu Ser Ala Val Cys Gly Ala Gln Gly Gly
 1               5                  10                  15      
Arg Ala Leu Leu Leu Arg Thr Pro Val Val Arg Pro Ala His Ile Ser
            20                  25                  30          
Ala Phe Leu Gln Asp Arg Pro Ile Pro Glu Trp Cys Gly Val Gln His
        35                  40                  45              
Ile His Leu Ser Pro Ser His His Ser Gly Ser Lys Ala Ala Ser Leu
    50                  55                  60                  
His Trp Thr Ser Glu Arg Val Val Ser Val Leu Leu Pro Gly Leu Leu
65                  70                  75                  80  
Pro Ala Ala Tyr Leu Asn Pro Cys Ser Ala Thr Asp Tyr Ser Leu Ala
                85                  90                  95      
Ala Ala Leu Thr Leu His Gly His Trp Gly Leu Gly Gln Val Val Thr
            100                 105                 110         
Asp Tyr Val His Gly Asp Ala Ser Gln Lys Ala Ala Lys Ala Gly Leu
        115                 120                 125             
Leu Ala Phe Ser Ala Leu Thr Phe Ala Gly Leu Cys Tyr Phe Asn Tyr
    130                 135                 140                 
His Asp Val Gly Ile Cys Lys Ala Val Ala Met Leu Trp Lys Leu
145                 150                 155                 


<210> 1948
<211> 301
<212> PRT
<213> Homo sapiens

<400> 1948
Met Ile Phe Leu Gln Arg Gln Leu Phe Leu Gly Leu Glu Ser Pro Met
 1               5                  10                  15      
Thr Ser Ser Thr Ala Val Met Arg Trp Met Pro Arg Arg Lys Thr Thr
            20                  25                  30          
Arg Val Arg Thr Val Ser Arg Lys Lys Lys Ser Lys Arg His Lys Glu
        35                  40                  45              
Glu Leu Asp Gly Ala Gly Gly Glu Glu Tyr Pro Met Asp Ile Trp Leu
    50                  55                  60                  
Leu Leu Ala Ser Tyr Ile Arg Pro Glu Asp Ile Val Asn Phe Ser Leu
65                  70                  75                  80  
Ile Cys Lys Asn Ala Trp Thr Val Thr Cys Thr Ala Ala Phe Trp Thr
                85                  90                  95      
Arg Leu Tyr Arg Arg His Tyr Thr Leu Asp Ala Ser Leu Pro Leu Arg
            100                 105                 110         
Leu Arg Pro Glu Ser Met Glu Lys Leu His Cys Leu Arg Ala Cys Val
        115                 120                 125             
Ile Arg Ser Leu Tyr His Met Tyr Glu Pro Phe Ala Ala Arg Ile Ser
    130                 135                 140                 
Lys Asn Pro Ala Ile Pro Glu Ser Thr Pro Ser Thr Leu Lys Asn Ser
145                 150                 155                 160 
Lys Cys Leu Leu Phe Trp Cys Arg Lys Ile Val Gly Asn Arg Gln Glu
                165                 170                 175     
Pro Met Trp Glu Phe Asn Phe Lys Phe Lys Lys Gln Ser Pro Arg Leu
            180                 185                 190         
Lys Ser Lys Cys Thr Gly Gly Leu Gln Pro Pro Val Gln Tyr Glu Asp
        195                 200                 205             
Val His Thr Asn Pro Asp Gln Asp Cys Cys Leu Leu Gln Val Thr Thr
    210                 215                 220                 
Leu Asn Phe Ile Phe Ile Pro Ile Val Met Gly Met Ile Phe Thr Leu
225                 230                 235                 240 
Phe Thr Ile Asn Val Ser Thr Asp Met Arg His His Arg Val Arg Leu
                245                 250                 255     
Val Phe Gln Asp Ser Pro Val His Gly Gly Arg Lys Leu Arg Ser Glu
            260                 265                 270         
Gln Gly Val Gln Val Ile Leu Asp Pro Val His Ser Val Arg Leu Phe
        275                 280                 285             
Asp Trp Trp His Pro Gln Tyr Pro Phe Ser Leu Arg Ala
    290                 295                 300     


<210> 1949
<211> 782
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 158, 159, 160, 161, 162, 163, 164, 165, 166, 167, 168, 169,
170, 171, 172, 173, 174, 610, 611, 612, 613, 614, 615, 616,
617, 618, 619, 620, 621, 622, 623, 624, 625, 626, 627, 628,
629, 630, 631, 632, 633, 634, 635, 636, 637, 638, 639
<223> Xaa = Any Amino Acid

<221> VARIANT        
<222> 640, 641, 642, 643, 644, 645, 646, 647, 648, 649
<223> Xaa = Any Amino Acid

<400> 1949
Met Gly Lys Arg Asp Arg Ala Asp Arg Asp Lys Lys Lys Ser Arg Lys
 1               5                  10                  15      
Arg His Tyr Glu Asp Glu Glu Asp Asp Glu Glu Asp Ala Pro Gly Asn
            20                  25                  30          
Asp Pro Gln Glu Ala Val Pro Ser Ala Ala Gly Lys Gln Val Asp Glu
        35                  40                  45              
Ser Gly Thr Lys Val Asp Glu Tyr Gly Ala Lys Asp Tyr Arg Leu Gln
    50                  55                  60                  
Met Pro Leu Lys Asp Asp His Thr Ser Arg Pro Leu Trp Val Ala Pro
65                  70                  75                  80  
Asp Gly His Ile Phe Leu Glu Ala Phe Ser Pro Val Tyr Lys Tyr Ala
                85                  90                  95      
Gln Asp Phe Leu Val Ala Ile Ala Glu Pro Val Cys Arg Pro Thr His
            100                 105                 110         
Val His Glu Tyr Lys Leu Thr Ala Tyr Ser Leu Tyr Ala Ala Val Ser
        115                 120                 125             
Val Gly Leu Gln Thr Ser Asp Ile Thr Glu Tyr Leu Arg Lys Leu Ser
    130                 135                 140                 
Lys Thr Gly Val Pro Asp Gly Ile Met Gln Phe Ile Lys Xaa Xaa Xaa
145                 150                 155                 160 
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Phe
                165                 170                 175     
Val Glu Ser Cys His Pro Asp Val Ile Gln His Leu Leu Gln Asp Pro
            180                 185                 190         
Val Ile Arg Glu Cys Arg Leu Arg Asn Ser Glu Gly Glu Ala Thr Glu
        195                 200                 205             
Leu Ile Thr Glu Thr Phe Thr Ser Lys Ser Ala Ile Ser Lys Thr Ala
    210                 215                 220                 
Glu Ser Ser Gly Gly Pro Ser Thr Ser Arg Val Thr Asp Pro Gln Gly
225                 230                 235                 240 
Lys Ser Asp Ile Pro Met Asp Leu Phe Asp Phe Tyr Glu Gln Met Asp
                245                 250                 255     
Lys Asp Glu Glu Glu Glu Glu Glu Thr Gln Thr Val Ser Phe Glu Val
            260                 265                 270         
Lys Gln Glu Met Ile Glu Glu Leu Gln Lys Arg Cys Ile His Leu Glu
        275                 280                 285             
Tyr Pro Leu Leu Ala Glu Tyr Asp Phe Arg Asn Asp Ser Val Asn Pro
    290                 295                 300                 
Asp Ile Asn Ile Asp Leu Lys Pro Thr Ala Val Leu Arg Pro Tyr Gln
305                 310                 315                 320 
Glu Lys Ser Leu Arg Lys Met Phe Gly Asn Gly Arg Ala Arg Ser Gly
                325                 330                 335     
Val Ile Val Leu Pro Cys Gly Ala Gly Lys Ser Leu Val Gly Val Thr
            340                 345                 350         
Ala Ala Cys Thr Val Arg Lys Arg Cys Leu Val Leu Gly Asn Ser Ala
        355                 360                 365             
Val Ser Val Glu Gln Trp Lys Ala Gln Phe Lys Met Trp Ser Thr Ile
    370                 375                 380                 
Asp Asp Ser Gln Ile Cys Arg Phe Thr Ser Asp Ala Lys Asp Lys Pro
385                 390                 395                 400 
Ile Gly Cys Ser Val Ala Ile Ser Thr Tyr Ser Met Leu Gly His Thr
                405                 410                 415     
Thr Lys Arg Ser Trp Glu Ala Glu Arg Val Met Glu Trp Leu Lys Thr
            420                 425                 430         
Gln Glu Trp Gly Leu Met Ile Leu Asp Glu Val His Thr Ile Pro Ala
        435                 440                 445             
Lys Met Phe Arg Arg Val Leu Thr Ile Val Gln Ala His Cys Lys Leu
    450                 455                 460                 
Gly Leu Thr Ala Thr Leu Val Arg Glu Asp Asp Lys Ile Val Asp Leu
465                 470                 475                 480 
Asn Phe Leu Ile Gly Pro Lys Leu Tyr Glu Ala Asn Trp Met Glu Leu
                485                 490                 495     
Gln Asn Asn Gly Tyr Ile Ala Lys Val Gln Cys Ala Glu Val Trp Cys
            500                 505                 510         
Pro Met Ser Pro Glu Phe Tyr Arg Glu Tyr Val Ala Ile Lys Thr Lys
        515                 520                 525             
Lys Arg Ile Leu Leu Tyr Thr Met Asn Pro Asn Lys Phe Arg Ala Cys
    530                 535                 540                 
Gln Phe Leu Ile Lys Phe His Glu Arg Arg Asn Asp Lys Ile Ile Val
545                 550                 555                 560 
Phe Ala Asp Asn Val Phe Ala Leu Lys Glu Tyr Ala Ile Arg Leu Asn
                565                 570                 575     
Lys Pro Tyr Ile Tyr Gly Pro Thr Ser Gln Gly Glu Arg Met Gln Ile
            580                 585                 590         
Leu Gln Asn Phe Lys His Asn Pro Lys Ile Asn Thr Ile Phe Ile Ser
        595                 600                 605             
Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    610                 615                 620                 
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
625                 630                 635                 640 
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Met Val Ala Glu Glu Tyr Asn
                645                 650                 655     
Ala Phe Phe Tyr Ser Leu Val Ser Gln Asp Thr Gln Glu Met Ala Tyr
            660                 665                 670         
Ser Thr Lys Arg Gln Arg Phe Leu Val Asp Gln Gly Tyr Ser Phe Lys
        675                 680                 685             
Val Ile Thr Lys Leu Ala Gly Met Glu Glu Glu Asp Leu Ala Phe Ser
    690                 695                 700                 
Thr Lys Glu Glu Gln Gln Gln Leu Leu Gln Lys Val Leu Ala Ala Thr
705                 710                 715                 720 
Asp Leu Asp Ala Glu Glu Glu Val Val Ala Gly Glu Phe Gly Ser Arg
                725                 730                 735     
Ser Ser Gln Ala Ser Arg Arg Phe Gly Thr Met Ser Ser Met Ser Gly
            740                 745                 750         
Ala Asp Asp Thr Val Tyr Met Glu Tyr His Ser Ser Arg Ser Lys Ala
        755                 760                 765             
Pro Ser Lys His Val His Pro Leu Phe Lys Arg Phe Arg Lys
    770                 775                 780         


<210> 1950
<211> 1358
<212> PRT
<213> Homo sapiens

<400> 1950
Met Gly Asn Gln Leu Ala Gly Ile Ala Pro Ser Gln Ile Leu Ser Val
 1               5                  10                  15      
Glu Ser Tyr Phe Ser Asp Ile His Asp Phe Glu Tyr Asp Lys Ser Leu
            20                  25                  30          
Gly Ser Thr Arg Phe Phe Lys Val Ala Arg Ala Lys His Arg Glu Gly
        35                  40                  45              
Leu Val Val Val Lys Val Phe Ala Ile Gln Asp Pro Thr Leu Pro Leu
    50                  55                  60                  
Thr Ser Tyr Lys Gln Glu Leu Glu Glu Leu Lys Ile Arg Leu Asn Ser
65                  70                  75                  80  
Ala Gln Asn Cys Leu Pro Phe Gln Lys Ala Ser Glu Lys Ala Ser Glu
                85                  90                  95      
Lys Ala Ala Met Leu Phe Arg Gln Tyr Val Arg Asp Asn Leu Tyr Asp
            100                 105                 110         
Arg Ile Ser Thr Arg Pro Phe Leu Asn Asn Ile Glu Lys Arg Trp Ile
        115                 120                 125             
Ala Phe Gln Ile Leu Thr Ala Val Asp Gln Ala His Lys Ser Gly Val
    130                 135                 140                 
Arg His Gly Asp Ile Lys Thr Glu Asn Val Met Val Thr Ser Trp Asn
145                 150                 155                 160 
Trp Val Leu Leu Thr Asp Phe Ala Ser Phe Lys Pro Thr Tyr Leu Pro
                165                 170                 175     
Glu Asp Asn Pro Ala Asp Phe Asn Tyr Phe Phe Asp Thr Ser Arg Arg
            180                 185                 190         
Arg Thr Cys Tyr Ile Ala Pro Glu Arg Phe Val Asp Gly Gly Met Phe
        195                 200                 205             
Ala Thr Glu Leu Glu Tyr Met Arg Asp Pro Ser Thr Pro Leu Val Asp
    210                 215                 220                 
Leu Asn Ser Asn Gln Arg Thr Arg Gly Glu Leu Lys Arg Ala Met Asp
225                 230                 235                 240 
Ile Phe Ser Ala Gly Cys Val Ile Ala Glu Leu Phe Thr Glu Gly Val
                245                 250                 255     
Pro Leu Phe Asp Leu Ser Gln Leu Leu Ala Tyr Arg Asn Gly His Phe
            260                 265                 270         
Phe Pro Glu Gln Val Leu Asn Lys Ile Glu Asp His Ser Ile Arg Glu
        275                 280                 285             
Leu Val Thr Gln Met Ile His Arg Glu Pro Asp Lys Arg Leu Glu Ala
    290                 295                 300                 
Glu Asp Tyr Leu Lys Gln Gln Arg Gly Asn Ala Phe Pro Glu Ile Phe
305                 310                 315                 320 
Tyr Thr Phe Leu Gln Pro Tyr Met Ala Gln Phe Ala Lys Glu Thr Phe
                325                 330                 335     
Leu Ser Ala Asp Glu Arg Ile Leu Val Ile Arg Lys Asp Leu Gly Asn
            340                 345                 350         
Ile Ile His Asn Leu Cys Gly His Asp Leu Pro Glu Lys Ala Glu Gly
        355                 360                 365             
Glu Pro Lys Glu Asn Gly Leu Val Ile Leu Val Ser Val Ile Thr Ser
    370                 375                 380                 
Cys Leu Gln Thr Leu Lys Tyr Cys Asp Ser Lys Leu Ala Ala Leu Glu
385                 390                 395                 400 
Leu Ile Leu His Leu Ala Pro Arg Leu Ser Val Glu Ile Leu Leu Asp
                405                 410                 415     
Arg Ile Thr Pro Tyr Leu Leu His Phe Ser Asn Asp Ser Val Pro Arg
            420                 425                 430         
Val Arg Ala Glu Ala Leu Arg Thr Leu Thr Lys Val Leu Ala Leu Val
        435                 440                 445             
Lys Glu Val Pro Arg Asn Asp Ile Asn Ile Tyr Pro Glu Tyr Ile Leu
    450                 455                 460                 
Pro Gly Ile Ala His Leu Ala Gln Asp Asp Ala Thr Ile Val Arg Leu
465                 470                 475                 480 
Ala Tyr Ala Glu Asn Ile Ala Leu Leu Ala Glu Thr Ala Leu Arg Phe
                485                 490                 495     
Leu Glu Leu Val Gln Leu Lys Asn Leu Asn Met Glu Asn Asp Pro Asn
            500                 505                 510         
Asn Glu Glu Ile Asp Glu Val Thr His Pro Asn Gly Asn Tyr Asp Thr
        515                 520                 525             
Glu Leu Gln Ala Leu His Glu Met Val Gln Gln Lys Val Val Thr Leu
    530                 535                 540                 
Leu Ser Asp Pro Glu Asn Ile Val Lys Gln Thr Leu Met Glu Asn Gly
545                 550                 555                 560 
Ile Thr Arg Leu Cys Val Phe Phe Gly Arg Gln Lys Ala Asn Asp Val
                565                 570                 575     
Leu Leu Ser His Met Ile Thr Phe Leu Asn Asp Lys Asn Asp Trp His
            580                 585                 590         
Leu Arg Gly Ala Phe Phe Asp Ser Ile Val Gly Val Ala Ala Tyr Val
        595                 600                 605             
Gly Trp Gln Ser Ser Ser Ile Leu Lys Pro Leu Leu Gln Gln Gly Leu
    610                 615                 620                 
Ser Asp Ala Glu Glu Phe Val Ile Val Lys Ala Leu Tyr Ala Leu Thr
625                 630                 635                 640 
Cys Met Cys Gln Leu Gly Leu Leu Gln Lys Pro His Val Tyr Glu Phe
                645                 650                 655     
Ala Ser Asp Ile Ala Pro Phe Leu Cys His Pro Asn Leu Trp Ile Arg
            660                 665                 670         
Tyr Gly Ala Val Gly Phe Ile Thr Val Val Ala Arg Gln Ile Ser Thr
        675                 680                 685             
Ala Asp Val Tyr Cys Lys Leu Met Pro Tyr Leu Asp Pro Tyr Ile Thr
    690                 695                 700                 
Gln Pro Ile Ile Gln Ile Glu Arg Lys Leu Val Leu Leu Ser Val Leu
705                 710                 715                 720 
Lys Glu Pro Val Ser Arg Ser Ile Phe Asp Tyr Ala Leu Arg Ser Lys
                725                 730                 735     
Asp Ile Thr Ser Leu Phe Arg His Leu His Met Arg Gln Lys Lys Arg
            740                 745                 750         
Asn Gly Ser Leu Pro Asp Cys Pro Pro Pro Glu Asp Pro Ala Ile Ala
        755                 760                 765             
Gln Leu Leu Lys Lys Leu Leu Ser Gln Gly Met Thr Glu Glu Glu Glu
    770                 775                 780                 
Asp Lys Leu Leu Ala Leu Lys Asp Phe Met Met Lys Ser Asn Lys Ala
785                 790                 795                 800 
Lys Ala Asn Ile Val Asp Gln Ser His Leu His Asp Ser Ser Gln Lys
                805                 810                 815     
Gly Val Ile Asp Leu Ala Ala Leu Gly Ile Thr Gly Arg Gln Val Asp
            820                 825                 830         
Leu Val Lys Thr Lys Gln Glu Pro Asp Asp Lys Arg Ala Arg Lys His
        835                 840                 845             
Val Lys Gln Asp Ser Asn Val Asn Glu Glu Trp Lys Ser Met Phe Gly
    850                 855                 860                 
Ser Leu Asp Pro Pro Asn Met Pro Gln Ala Leu Pro Lys Gly Ser Asp
865                 870                 875                 880 
Gln Glu Val Ile Gln Thr Gly Lys Pro Pro Arg Ser Glu Ser Ser Ala
                885                 890                 895     
Gly Ile Cys Val Pro Leu Ser Thr Ser Ser Gln Val Pro Glu Val Thr
            900                 905                 910         
Thr Val Gln Asn Lys Lys Pro Val Ile Pro Val Leu Ser Ser Thr Ile
        915                 920                 925             
Leu Pro Ser Thr Tyr Gln Ile Arg Ile Thr Thr Cys Lys Thr Glu Leu
    930                 935                 940                 
Gln Gln Leu Ile Gln Gln Lys Arg Glu Gln Cys Asn Ala Glu Arg Ile
945                 950                 955                 960 
Ala Lys Gln Met Met Glu Asn Ala Glu Trp Glu Ser Lys Pro Pro Pro
                965                 970                 975     
Pro Gly Trp Arg Pro Lys Gly Leu Leu Val Ala His Leu His Glu His
            980                 985                 990         
Lys Ser Ala Val Asn Arg Ile Arg Val Ser Asp Glu His Ser Leu Phe
        995                 1000                1005            
Ala Thr Cys Ser Asn Asp Gly Thr Val Lys Ile Trp Asn Ser Gln Lys
    1010                1015                1020                
Met Glu Gly Lys Thr Thr Thr Thr Arg Ser Ile Leu Thr Tyr Ser Arg
1025                1030                1035                1040
Ile Gly Gly Arg Val Lys Thr Leu Thr Phe Cys Gln Gly Ser His Tyr
                1045                1050                1055    
Leu Ala Ile Ala Ser Asp Asn Gly Ala Val Gln Leu Leu Gly Ile Glu
            1060                1065                1070        
Ala Ser Lys Leu Pro Lys Ser Pro Lys Ile His Pro Leu Gln Ser Arg
        1075                1080                1085            
Ile Leu Asp Gln Lys Glu Asp Gly Cys Val Val Asp Met His His Phe
    1090                1095                1100                
Asn Ser Gly Ala Gln Ser Val Leu Ala Tyr Ala Thr Val Asn Gly Ser
1105                1110                1115                1120
Leu Val Gly Trp Asp Leu Arg Ser Ser Ser Asn Ala Trp Thr Leu Lys
                1125                1130                1135    
His Asp Leu Lys Ser Gly Leu Ile Thr Ser Phe Ala Val Asp Ile His
            1140                1145                1150        
Gln Cys Trp Leu Cys Ile Gly Thr Ser Ser Gly Thr Met Ala Cys Trp
        1155                1160                1165            
Asp Met Arg Phe Gln Leu Pro Ile Ser Ser His Cys His Pro Ser Arg
    1170                1175                1180                
Ala Arg Ile Arg Arg Leu Ser Met His Pro Leu Tyr Gln Ser Trp Val
1185                1190                1195                1200
Ile Ala Ala Val Gln Gly Asn Asn Glu Val Ser Met Trp Asp Met Glu
                1205                1210                1215    
Thr Gly Asp Arg Arg Phe Thr Leu Trp Ala Ser Ser Ala Pro Pro Leu
            1220                1225                1230        
Ser Glu Leu Gln Pro Ser Pro His Ser Val His Gly Ile Tyr Cys Ser
        1235                1240                1245            
Pro Ala Asp Gly Asn Pro Ile Leu Leu Thr Ala Gly Ser Asp Met Lys
    1250                1255                1260                
Ile Arg Phe Trp Asp Leu Ala Tyr Pro Glu Arg Ser Tyr Val Val Ala
1265                1270                1275                1280
Gly Ser Thr Ser Ser Pro Ser Val Ser Tyr Tyr Arg Lys Ile Ile Glu
                1285                1290                1295    
Gly Thr Glu Val Val Gln Glu Ile Gln Asn Lys Gln Lys Val Gly Pro
            1300                1305                1310        
Ser Asp Asp Thr Pro Arg Arg Gly Pro Glu Ser Leu Pro Val Gly His
        1315                1320                1325            
His Asp Ile Ile Thr Asp Val Ala Thr Phe Gln Thr Thr Gln Gly Phe
    1330                1335                1340                
Ile Val Thr Ala Ser Arg Asp Gly Ile Val Lys Val Trp Lys
1345                1350                1355            


<210> 1951
<211> 121
<212> PRT
<213> Homo sapiens

<400> 1951
Met Leu Leu Ala Ser Arg Phe Pro Pro Pro Asp Phe Gln Ala Val Thr
 1               5                  10                  15      
Cys Phe Leu Phe Ser Pro Leu Trp Val Asp Cys Ile Ser Arg Leu Ser
            20                  25                  30          
Pro Ala Gln Ala His Leu Pro Lys Gln Glu Glu Gly Met Ile Met Val
        35                  40                  45              
Thr Gln Gly Lys Lys Lys Gln Pro Ser Ser Glu Ser Leu Asp Cys Pro
    50                  55                  60                  
Ala Val Asn Trp Leu Ala Gly Ser Ala Arg Gly Trp Gly Pro Gly Pro
65                  70                  75                  80  
Gly Leu Tyr Ser Ile Ala Glu Lys Lys Leu Ser Pro Cys Ile Ser Tyr
                85                  90                  95      
Leu Tyr Leu Trp Pro Val Gly His Gln Gly Glu Trp Ala Glu Gly Arg
            100                 105                 110         
Val Asp Gly Ala Lys Gln Ala His Leu
        115                 120     


<210> 1952
<211> 341
<212> PRT
<213> Homo sapiens

<400> 1952
Met Asn Val Tyr Glu Thr Thr Glu Phe Asp Gln Leu Arg Arg Leu Ser
 1               5                  10                  15      
Thr Pro Pro Ser Ser Asn Val Asn Ser Ile Tyr His Thr Val Trp Lys
            20                  25                  30          
Phe Phe Cys Arg Asp His Phe Gly Trp Arg Glu Tyr Pro Glu Ser Val
        35                  40                  45              
Ile Arg Leu Ile Glu Glu Ala Asn Ser Arg Gly Leu Lys Glu Val Arg
    50                  55                  60                  
Phe Met Met Trp Asn Asn His Tyr Ile Leu His Asn Ser Phe Phe Arg
65                  70                  75                  80  
Arg Glu Ile Lys Arg Arg Pro Leu Phe Arg Ser Cys Phe Ile Leu Leu
                85                  90                  95      
Pro Tyr Leu Gln Thr Leu Gly Gly Val Pro Thr Gln Ala Pro Pro Pro
            100                 105                 110         
Leu Glu Ala Thr Ser Ser Ser Gln Ile Ile Cys Pro Asp Gly Val Thr
        115                 120                 125             
Ser Ala Asn Phe Tyr Pro Glu Thr Trp Val Tyr Met His Pro Ser Gln
    130                 135                 140                 
Asp Phe Ile Gln Val Pro Val Ser Ala Glu Asp Lys Ser Tyr Arg Ile
145                 150                 155                 160 
Ile Tyr Asn Leu Phe His Lys Thr Val Pro Glu Phe Lys Tyr Arg Ile
                165                 170                 175     
Leu Gln Ile Leu Arg Val Gln Asn Gln Phe Leu Trp Glu Lys Tyr Lys
            180                 185                 190         
Arg Lys Lys Glu Tyr Met Asn Arg Lys Met Phe Gly Arg Asp Arg Ile
        195                 200                 205             
Ile Asn Glu Arg His Leu Phe His Gly Thr Ser Gln Asp Val Val Asp
    210                 215                 220                 
Gly Ile Cys Lys His Asn Phe Asp Pro Arg Val Cys Gly Lys His Ala
225                 230                 235                 240 
Thr Met Phe Gly Gln Gly Ser Tyr Phe Ala Lys Lys Ala Ser Tyr Ser
                245                 250                 255     
His Asn Phe Ser Lys Lys Ser Ser Lys Gly Val His Phe Met Phe Leu
            260                 265                 270         
Ala Lys Val Leu Thr Gly Arg Tyr Thr Met Gly Ser His Gly Met Arg
        275                 280                 285             
Arg Pro Pro Pro Val Asn Pro Gly Ser Val Thr Ser Asp Leu Tyr Asp
    290                 295                 300                 
Ser Cys Val Asp Asn Phe Phe Glu Pro Gln Ile Phe Val Ile Phe Asn
305                 310                 315                 320 
Asp Asp Gln Ser Tyr Pro Tyr Phe Val Ile Gln Tyr Glu Glu Val Ser
                325                 330                 335     
Asn Thr Val Ser Ile
            340     


<210> 1953
<211> 1098
<212> PRT
<213> Homo sapiens

<400> 1953
Met Tyr Cys Gln Glu Glu Leu Phe Glu Glu Ala Ala Ile Ala Val Glu
 1               5                  10                  15      
Lys Tyr Glu Glu Met Leu Lys Thr Lys Thr Leu Pro Ile Ser Lys Leu
            20                  25                  30          
Ser Tyr Ser Ala Ser Gln Phe Tyr Leu Glu Ala Ala Ala Lys Tyr Leu
        35                  40                  45              
Ser Ala Asn Lys Met Lys Glu Met Met Ala Val Leu Ser Lys Leu Asp
    50                  55                  60                  
Ile Glu Asp Gln Leu Val Phe Leu Lys Ser Arg Lys Arg Leu Ala Glu
65                  70                  75                  80  
Ala Ala Asp Leu Leu Asn Arg Glu Gly Arg Arg Glu Glu Ala Ala Leu
                85                  90                  95      
Leu Met Lys Gln His Gly Cys Leu Leu Glu Ala Ala Arg Leu Thr Ala
            100                 105                 110         
Asp Lys Asp Phe Gln Ala Ser Cys Leu Leu Gly Ala Ala Arg Leu Asn
        115                 120                 125             
Val Ala Arg Asp Ser Asp Ile Glu His Thr Lys Asp Ile Leu Arg Glu
    130                 135                 140                 
Ala Leu Asp Ile Cys Tyr Gln Thr Gly Gln Leu Ser Gly Ile Ala Glu
145                 150                 155                 160 
Ala His Phe Leu Gln Gly Val Ile Leu Arg Asp Phe Gln Lys Leu Arg
                165                 170                 175     
Asp Ala Phe Phe Lys Phe Asp Thr Leu Asn His Ser Ala Gly Val Val
            180                 185                 190         
Glu Ala Leu Tyr Glu Ala Ala Ser Gln Cys Glu Ala Glu Pro Glu Lys
        195                 200                 205             
Ile Leu Gly Leu Ala Pro Gly Gly Leu Glu Ile Leu Leu Ser Leu Val
    210                 215                 220                 
Arg Ala Leu Lys Arg Val Thr Asn Asn Ala Glu Lys Glu Met Val Lys
225                 230                 235                 240 
Ser Cys Phe Glu Phe Phe Gly Ile Ser Gln Val Asp Ala Lys Tyr Cys
                245                 250                 255     
Gln Ile Ala Gln Asn Asp Pro Gly Pro Ile Leu Arg Ile Ile Phe Asp
            260                 265                 270         
Leu Asp Leu Asn Leu Arg Glu Lys Lys Thr Lys Asp His Phe Leu Ile
        275                 280                 285             
Met Thr Asp Gln Val Lys Leu Ala Leu Asn Lys His Leu Leu Gly Arg
    290                 295                 300                 
Leu Cys Gln Ile Thr Arg Ser Leu Leu Gly Lys Thr Tyr Arg Gly Val
305                 310                 315                 320 
Cys Met Arg Phe Ile Val Gly Leu Lys Cys Glu Asp Glu Asn Cys Glu
                325                 330                 335     
His Phe His Arg Pro Leu Arg Arg Cys Glu Ala Lys Cys Leu Val Gln
            340                 345                 350         
Ser Lys Met Asn Leu Val Ala Ile Asn Gly Leu Leu Leu Glu Ala Lys
        355                 360                 365             
Lys Val Phe Pro Lys Ile Leu Ala Glu Glu Leu Lys Glu Ile Asp Tyr
    370                 375                 380                 
Ile Leu Ser Thr Asp Met Tyr Gly Leu Cys Lys Ser Ile Leu Asp Val
385                 390                 395                 400 
Leu Phe Pro Lys His Phe His Gln Arg Val Leu Ser Glu Asn Pro Met
                405                 410                 415     
Ala Cys Lys Glu Ile Leu Lys Pro Asn Tyr Lys Ser Phe Arg Phe Tyr
            420                 425                 430         
Arg Phe Ala Leu Lys Glu Tyr Ile His Phe Leu Phe Glu Asn Glu Ser
        435                 440                 445             
Ala Arg Asn Arg Arg Glu Ser Thr Asp Leu Trp Leu Ser Ala Met Gln
    450                 455                 460                 
Ala Phe Leu Leu Ser Ser Asn Tyr Pro Glu Glu Phe Glu Lys Leu Leu
465                 470                 475                 480 
His Gln Glu Glu Asp Asn Tyr Asn Arg Glu Leu Lys Ala Leu Glu Ser
                485                 490                 495     
Glu Lys Asp Glu Arg Gly Arg Gly Arg Gly Ser Arg Ile Lys Gly Ile
            500                 505                 510         
Glu Gly Lys Phe Gly Met Leu Ala Pro Asn Arg Asp Asp Glu Asn Met
        515                 520                 525             
Asp Lys Thr His Leu Cys Phe Ile Arg Leu Leu Glu Asn Cys Ile Asp
    530                 535                 540                 
Gln Phe Tyr Val Tyr Arg Asn Pro Glu Asp Tyr Lys Arg Leu Phe Phe
545                 550                 555                 560 
Arg Phe Met Asn Val Leu Ile Lys Arg Cys Lys Glu Pro Leu Ile Pro
                565                 570                 575     
Ser Ile Gly Asn Thr Val Ala Leu Leu Glu Phe Gln Phe Ile His Cys
            580                 585                 590         
Gly Val Val Leu Ala Arg Leu Trp Lys Asn Val Ile Leu Cys Leu Pro
        595                 600                 605             
Lys Ser Tyr Ile Ala Leu Leu His Tyr Trp Glu Phe Leu Phe Ser Lys
    610                 615                 620                 
Lys Asp Lys Glu Leu Gly Asp Val Phe Ser Ile Ile Gln Glu Tyr Lys
625                 630                 635                 640 
Pro Lys Asp Val Thr Arg Ala Ile Gln Asp Phe Arg Phe His Leu Ser
                645                 650                 655     
Tyr Leu Ala Lys Val Leu Cys Gly Tyr Glu Asn Val Asn Phe Asn Val
            660                 665                 670         
Leu Leu Asp Ala Phe Ser Glu Ile Asp Tyr Val Val Ser Gly Glu Ala
        675                 680                 685             
Glu Arg Thr Leu Val Leu Cys Leu Val Met Leu Val Asn Ala Glu Glu
    690                 695                 700                 
Ile Leu Gln Pro Tyr Cys Lys Pro Leu Leu Tyr Arg His Phe Arg Glu
705                 710                 715                 720 
Ile Glu Ser Arg Leu Gln Leu Met Ser Met Asp Cys Pro Gly Gln Val
                725                 730                 735     
Pro Glu Arg Leu Leu Lys Val Val Lys Arg Val Leu Val Ala Val Asn
            740                 745                 750         
Val Lys Ser Val Ala Glu Ala Leu Gln Asp Leu Leu Phe Glu Arg Asp
        755                 760                 765             
Glu Glu Tyr Leu Met Asp Cys Asp Trp Arg Trp Asp Pro Val His Thr
    770                 775                 780                 
Lys Gly Ser Ile Val Arg Gly Leu Tyr Tyr Glu Glu Val Arg Leu Asn
785                 790                 795                 800 
Arg Leu Leu Cys Leu Asp Pro Val Asp Tyr Phe Ala Glu Pro Glu Cys
                805                 810                 815     
Glu Phe Gly Gln Asp Glu Met Asp Glu Leu Ala Leu Glu Asp Arg Asp
            820                 825                 830         
His Val Leu Ala Thr Ile Leu Ser Gln Lys Gln Arg Lys Ala Ser Ile
        835                 840                 845             
Gln Arg Lys Leu Arg Arg Ala Cys Leu Val Val Ser Leu Cys Ile Ser
    850                 855                 860                 
Trp Arg Arg Arg Val Gly Thr Gln Met Glu Arg Val Arg Glu Glu Ala
865                 870                 875                 880 
Arg Glu Pro Arg Ala Gly Asn Phe Lys Lys Ala Asp Val Asp Arg Thr
                885                 890                 895     
Gln Cys Asp Leu Cys Gly Val Lys Phe Thr Arg Gly Pro Glu Asn Tyr
            900                 905                 910         
Phe Ser Pro Ser Lys Ala Phe Glu Gly Ala Ala Ser Glu Val Ala Val
        915                 920                 925             
Leu Ser Arg Ala Glu Leu Glu Arg Glu Glu Cys Gln Glu Arg Asn Ser
    930                 935                 940                 
Glu Ser Tyr Glu Gln His Ile His Leu Glu His His Gln Arg Gln Gln
945                 950                 955                 960 
Val Ala Tyr Gln Lys Tyr Ser Glu Phe Phe His Glu Lys Val Asp Pro
                965                 970                 975     
Ala Ile Asp Glu Gly Lys Leu Val Val Gln Asp Ile Glu Gln Ser Val
            980                 985                 990         
Trp Ile His Ser His Val Gly Ser Lys Glu His Ser His Met Leu Gln
        995                 1000                1005            
Lys Val Gln Glu His Ile Lys Arg Val Ser Asp Met Val Glu Asp Leu
    1010                1015                1020                
Tyr Arg Arg Lys Ala Trp Ala Gly Ala Glu Glu Ala Met Thr Arg Leu
1025                1030                1035                1040
Val Asn Ile Leu Ile Leu Ser Val Arg Asp Ala Arg Asp Trp Leu Met
                1045                1050                1055    
Lys Thr Glu Thr Arg Leu Lys Lys Glu Gly Ile Val Gln Glu Asp Asp
            1060                1065                1070        
Tyr Glu Asn Glu Val Glu Asp Phe Gly Glu Leu Arg Pro Arg Arg Arg
        1075                1080                1085            
Ser Arg Lys Cys Gly Lys Gln Arg Lys Tyr
    1090                1095            


<210> 1954
<211> 48
<212> PRT
<213> Homo sapiens

<400> 1954
Met Gln Ala Lys Glu Met Asp Glu Glu Asp Lys Ala Phe Lys Gln Lys
 1               5                  10                  15      
Gln Lys Glu Glu Gln Lys Lys Leu Glu Glu Leu Lys Trp Lys Ala Thr
            20                  25                  30          
Gly Lys Gly Pro Leu Ala Thr Ser Gly Ile Lys Lys Ser Gly Lys Lys
        35                  40                  45              


<210> 1955
<211> 143
<212> PRT
<213> Homo sapiens

<400> 1955
Met Gly Phe Pro Glu Ala Ala Ser Ser Phe Arg Thr His Gln Ile Glu
 1               5                  10                  15      
Ala Val Pro Thr Ser Ser Ala Ser Asp Gly Phe Lys Ala Asn Leu Val
            20                  25                  30          
Phe Lys Glu Ile Glu Lys Lys Leu Glu Glu Glu Gly Glu Gln Phe Val
        35                  40                  45              
Lys Lys Ile Gly Gly Ile Phe Ala Phe Lys Val Lys Asp Gly Pro Gly
    50                  55                  60                  
Gly Lys Glu Ala Thr Trp Val Val Asp Val Lys Asn Gly Lys Gly Ser
65                  70                  75                  80  
Val Leu Pro Asn Ser Asp Lys Lys Ala Asp Cys Thr Ile Thr Met Ala
                85                  90                  95      
Asp Ser Asp Phe Leu Ala Leu Met Thr Gly Lys Met Asn Pro Gln Ser
            100                 105                 110         
Ala Phe Phe Gln Gly Lys Leu Lys Ile Thr Gly Asn Met Gly Leu Ala
        115                 120                 125             
Met Lys Leu Gln Asn Leu Gln Leu Gln Pro Gly Asn Ala Lys Leu
    130                 135                 140             


<210> 1956
<211> 183
<212> PRT
<213> Homo sapiens

<400> 1956
Met Gln Glu Pro Trp Leu Pro Gly Ala Arg Gln Gly Thr Arg Gly Gln
 1               5                  10                  15      
Met Pro Leu Glu Ala Val Pro Leu Arg Glu Val Leu Pro Asp Leu Arg
            20                  25                  30          
Ala Pro Glu Asp His Gly Arg Ala Glu Gly Ala Gln Asp Ala Gly Arg
        35                  40                  45              
Arg Gly Gly Ala Gly Gly Gly Pro Val Cys Ala Gly Ala Gln Ala Gly
    50                  55                  60                  
Leu Arg Gly Cys Gly Arg Arg Pro Arg Pro Arg Pro Arg Pro Gly Arg
65                  70                  75                  80  
Glu Pro Pro Pro Ala Val Pro Gly Asp Ser Leu Arg Arg Arg Arg Pro
                85                  90                  95      
Gly Thr Arg Gly Pro Arg Gly Arg Leu Leu Leu Arg Ala Ala Pro Ala
            100                 105                 110         
Gly Pro Glu Pro Arg Pro Glu Ser Pro Pro Ala Gly Ser Gly Arg Pro
        115                 120                 125             
Gln Pro Arg Gly Ala Glu Arg Ala Ser Arg Arg Gly Asp Ala Gln Pro
    130                 135                 140                 
Cys Gly Thr Pro Phe Trp Gly Gly Gly Arg Arg Gln Trp Leu Pro Trp
145                 150                 155                 160 
Pro Pro Arg Pro Ala Gln Ala Asp Ala Asp Arg Ala Arg Pro Thr Val
                165                 170                 175     
His Arg Leu Trp Cys Ala Leu
            180             


<210> 1957
<211> 1016
<212> PRT
<213> Homo sapiens

<400> 1957
Met Ala Pro Arg Thr Leu Trp Ser Cys Tyr Leu Cys Cys Leu Leu Thr
 1               5                  10                  15      
Ala Ala Ala Gly Ala Ala Ser Tyr Pro Pro Arg Gly Phe Ser Leu Tyr
            20                  25                  30          
Thr Gly Ser Ser Gly Ala Leu Ser Pro Gly Gly Pro Gln Ala Gln Ile
        35                  40                  45              
Ala Pro Arg Pro Ala Ser Arg His Arg Asn Trp Cys Ala Tyr Val Val
    50                  55                  60                  
Thr Arg Thr Val Ser Cys Val Leu Glu Asp Gly Val Glu Thr Tyr Val
65                  70                  75                  80  
Lys Tyr Gln Pro Cys Ala Trp Gly Gln Pro Gln Cys Pro Gln Ser Ile
                85                  90                  95      
Met Tyr Arg Arg Phe Leu Arg Pro Arg Tyr Arg Val Ala Tyr Lys Thr
            100                 105                 110         
Val Thr Asp Met Glu Trp Arg Cys Cys Gln Gly Tyr Gly Gly Asp Asp
        115                 120                 125             
Cys Ala Glu Ser Pro Ala Pro Ala Leu Gly Pro Ala Ser Ser Thr Pro
    130                 135                 140                 
Arg Pro Leu Ala Gln Pro Ala Arg Pro Asn Leu Ser Gly Ser Ser Ala
145                 150                 155                 160 
Gly Ser Pro Leu Ser Gly Leu Gly Gly Glu Gly Pro Gly Glu Ser Glu
                165                 170                 175     
Lys Val Gln Gln Leu Glu Glu Gln Val Gln Ser Leu Thr Lys Glu Leu
            180                 185                 190         
Gln Gly Leu Arg Gly Val Leu Gln Gly Leu Ser Gly Arg Leu Ala Glu
        195                 200                 205             
Asp Val Gln Arg Ala Val Glu Thr Ala Phe Asn Gly Arg Gln Gln Pro
    210                 215                 220                 
Ala Asp Ala Ala Ala Arg Pro Gly Val His Glu Thr Leu Asn Glu Ile
225                 230                 235                 240 
Gln His Gln Leu Gln Leu Leu Asp Thr Arg Val Ser Thr His Asp Gln
                245                 250                 255     
Glu Leu Gly His Leu Asn Asn His His Gly Gly Ser Ser Ser Ser Gly
            260                 265                 270         
Gly Ser Arg Ala Pro Ala Pro Ala Ser Ala Pro Pro Gly Pro Ser Glu
        275                 280                 285             
Glu Leu Leu Arg Gln Leu Glu Gln Arg Leu Gln Glu Ser Cys Ser Val
    290                 295                 300                 
Cys Leu Ala Gly Leu Asp Gly Phe Arg Arg Gln Gln Gln Glu Asp Arg
305                 310                 315                 320 
Glu Arg Leu Arg Ala Met Glu Lys Leu Leu Ala Ser Val Glu Glu Arg
                325                 330                 335     
Gln Arg His Leu Ala Gly Leu Ala Val Gly Arg Arg Pro Pro Gln Glu
            340                 345                 350         
Cys Cys Ser Pro Glu Leu Gly Arg Arg Leu Ala Glu Leu Glu Arg Arg
        355                 360                 365             
Leu Asp Val Val Ala Gly Ser Val Thr Val Leu Ser Gly Arg Arg Gly
    370                 375                 380                 
Thr Glu Leu Gly Gly Ala Ala Gly Gln Gly Gly His Pro Pro Gly Tyr
385                 390                 395                 400 
Thr Ser Leu Ala Ser Arg Leu Ser Arg Leu Glu Asp Arg Phe Asn Ser
                405                 410                 415     
Thr Leu Gly Pro Ser Glu Glu Gln Glu Glu Ser Trp Pro Gly Ala Pro
            420                 425                 430         
Gly Gly Leu Ser His Trp Leu Pro Ala Ala Arg Gly Arg Leu Glu Gln
        435                 440                 445             
Leu Gly Gly Leu Leu Ala Asn Val Ser Gly Glu Leu Gly Gly Arg Leu
    450                 455                 460                 
Asp Leu Leu Glu Glu Gln Val Ala Gly Ala Met Gln Ala Cys Gly Gln
465                 470                 475                 480 
Leu Cys Ser Gly Ala Pro Gly Glu Gln Asp Ser Gln Val Ser Glu Ile
                485                 490                 495     
Leu Ser Ala Leu Glu Arg Arg Val Leu Asp Ser Glu Gly Gln Leu Arg
            500                 505                 510         
Leu Val Gly Ser Gly Leu His Thr Val Glu Ala Ala Gly Glu Ala Arg
        515                 520                 525             
Gln Ala Thr Leu Glu Gly Leu Gln Glu Val Val Gly Arg Leu Gln Asp
    530                 535                 540                 
Arg Val Asp Ala Gln Asp Glu Thr Ala Ala Glu Phe Thr Leu Arg Leu
545                 550                 555                 560 
Asn Leu Thr Ala Ala Arg Leu Gly Gln Leu Glu Gly Leu Leu Gln Ala
                565                 570                 575     
His Gly Asp Glu Gly Cys Gly Ala Cys Gly Gly Val Gln Glu Glu Leu
            580                 585                 590         
Gly Arg Leu Arg Asp Gly Val Glu Arg Cys Ser Cys Pro Leu Leu Pro
        595                 600                 605             
Pro Arg Gly Pro Gly Ala Gly Pro Gly Val Gly Gly Pro Ser Arg Gly
    610                 615                 620                 
Pro Leu Asp Gly Phe Ser Val Phe Gly Gly Ser Ser Gly Ser Ala Leu
625                 630                 635                 640 
Gln Ala Leu Gln Gly Glu Leu Ser Glu Val Ile Leu Ser Phe Ser Ser
                645                 650                 655     
Leu Asn Asp Ser Leu Asn Glu Leu Gln Thr Thr Val Glu Gly Gln Gly
            660                 665                 670         
Ala Asp Leu Ala Asp Leu Gly Ala Thr Lys Asp Arg Ile Ile Ser Glu
        675                 680                 685             
Ile Asn Arg Leu Gln Gln Glu Ala Thr Glu His Ala Thr Glu Ser Glu
    690                 695                 700                 
Glu Arg Phe Arg Gly Leu Glu Glu Gly Gln Ala Gln Ala Gly Gln Cys
705                 710                 715                 720 
Pro Ser Leu Glu Gly Arg Leu Gly Arg Leu Glu Gly Val Cys Glu Arg
                725                 730                 735     
Leu Asp Thr Val Ala Gly Gly Leu Gln Gly Leu Arg Glu Gly Leu Ser
            740                 745                 750         
Arg His Val Ala Gly Leu Trp Ala Gly Leu Arg Glu Thr Asn Thr Thr
        755                 760                 765             
Ser Gln Met Gln Ala Ala Leu Leu Glu Lys Leu Val Gly Gly Gln Ala
    770                 775                 780                 
Gly Leu Gly Arg Arg Leu Gly Ala Leu Asn Ser Ser Leu Gln Leu Leu
785                 790                 795                 800 
Glu Asp Arg Leu His Gln Leu Ser Leu Lys Asp Leu Thr Gly Pro Ala
                805                 810                 815     
Gly Glu Ala Gly Pro Pro Gly Pro Pro Gly Leu Gln Gly Pro Pro Gly
            820                 825                 830         
Pro Ala Gly Pro Pro Gly Ser Pro Gly Lys Asp Gly Gln Glu Gly Pro
        835                 840                 845             
Ile Gly Pro Pro Gly Pro Gln Gly Glu Gln Gly Val Glu Gly Ala Pro
    850                 855                 860                 
Ala Ala Pro Val Pro Gln Val Ala Phe Ser Ala Ala Leu Ser Leu Pro
865                 870                 875                 880 
Arg Ser Glu Pro Gly Thr Val Pro Phe Asp Arg Val Leu Leu Asn Asp
                885                 890                 895     
Gly Gly Tyr Tyr Asp Pro Glu Thr Gly Val Phe Thr Ala Pro Leu Ala
            900                 905                 910         
Gly Arg Tyr Leu Leu Ser Ala Val Leu Thr Gly His Arg His Glu Lys
        915                 920                 925             
Val Glu Ala Val Leu Ser Arg Ser Asn Gln Gly Val Ala Arg Val Asp
    930                 935                 940                 
Ser Gly Gly Tyr Glu Pro Glu Gly Leu Glu Asn Lys Pro Val Ala Glu
945                 950                 955                 960 
Ser Gln Pro Ser Pro Gly Thr Leu Gly Val Phe Ser Leu Ile Leu Pro
                965                 970                 975     
Leu Gln Ala Gly Asp Thr Val Cys Val Asp Leu Val Met Gly Gln Leu
            980                 985                 990         
Ala His Ser Glu Glu Pro Leu Thr Ile Phe Ser Gly Ala Leu Leu Tyr
        995                 1000                1005            
Gly Asp Pro Glu Leu Glu His Ala
    1010                1015    


<210> 1958
<211> 1426
<212> PRT
<213> Homo sapiens

<400> 1958
Met His Ser Ser Asn Pro Lys Val Arg Ser Ser Pro Ser Gly Asn Thr
 1               5                  10                  15      
Gln Ser Ser Pro Lys Ser Lys Gln Glu Val Met Val Arg Pro Pro Thr
            20                  25                  30          
Val Met Ser Pro Ser Gly Asn Pro Gln Leu Asp Ser Lys Phe Ser Asn
        35                  40                  45              
Gln Gly Lys Gln Gly Gly Ser Ala Ser Gln Ser Gln Pro Ser Pro Cys
    50                  55                  60                  
Asp Ser Lys Ser Gly Gly His Thr Pro Lys Ala Leu Pro Gly Pro Gly
65                  70                  75                  80  
Gly Ser Met Gly Leu Lys Asn Gly Ala Gly Asn Gly Ala Lys Gly Lys
                85                  90                  95      
Gly Lys Arg Glu Arg Ser Ile Ser Ala Asp Ser Phe Asp Gln Arg Asp
            100                 105                 110         
Pro Gly Thr Pro Asn Asp Asp Ser Asp Ile Lys Glu Cys Asn Ser Ala
        115                 120                 125             
Asp His Ile Lys Ser Gln Asp Ser Gln His Thr Pro His Ser Met Thr
    130                 135                 140                 
Pro Ser Asn Ala Thr Ala Pro Arg Ser Ser Thr Pro Ser His Gly Gln
145                 150                 155                 160 
Thr Thr Ala Thr Glu Pro Thr Pro Ala Gln Lys Thr Pro Ala Lys Val
                165                 170                 175     
Val Tyr Val Phe Ser Thr Glu Met Ala Asn Lys Ala Ala Glu Ala Val
            180                 185                 190         
Leu Lys Gly Gln Val Glu Thr Ile Val Ser Phe His Ile Gln Asn Ile
        195                 200                 205             
Ser Asn Asn Lys Thr Glu Arg Ser Thr Ala Pro Leu Asn Thr Gln Ile
    210                 215                 220                 
Ser Ala Leu Arg Asn Asp Pro Lys Pro Leu Pro Gln Gln Pro Pro Ala
225                 230                 235                 240 
Pro Ala Asn Gln Asp Gln Asn Ser Ser Gln Asn Thr Arg Leu Gln Pro
                245                 250                 255     
Thr Pro Pro Ile Pro Ala Pro Ala Pro Lys Pro Ala Ala Pro Pro Arg
            260                 265                 270         
Pro Leu Asp Arg Glu Ser Pro Gly Val Glu Asn Lys Leu Ile Pro Ser
        275                 280                 285             
Val Gly Ser Pro Ala Ser Ser Thr Pro Leu Pro Pro Asp Gly Thr Gly
    290                 295                 300                 
Pro Asn Ser Thr Pro Asn Asn Arg Ala Val Thr Pro Val Ser Gln Gly
305                 310                 315                 320 
Ser Asn Ser Ser Ser Ala Asp Pro Lys Ala Pro Pro Pro Pro Pro Val
                325                 330                 335     
Ser Ser Gly Glu Pro Pro Thr Leu Gly Glu Asn Pro Asp Gly Leu Ser
            340                 345                 350         
Gln Glu Gln Leu Glu His Arg Glu Arg Ser Leu Gln Thr Leu Arg Asp
        355                 360                 365             
Ile Gln Arg Met Leu Phe Pro Asp Glu Lys Glu Phe Thr Gly Ala Gln
    370                 375                 380                 
Ser Gly Gly Pro Gln Gln Asn Pro Gly Val Leu Asp Gly Pro Gln Lys
385                 390                 395                 400 
Lys Pro Glu Gly Pro Ile Gln Ala Met Met Ala Gln Ser Gln Ser Leu
                405                 410                 415     
Gly Lys Gly Pro Gly Pro Arg Thr Asp Val Gly Ala Pro Phe Gly Pro
            420                 425                 430         
Gln Gly His Arg Asp Val Pro Phe Ser Pro Asp Glu Met Val Pro Pro
        435                 440                 445             
Ser Met Asn Ser Gln Ser Gly Thr Ile Gly Pro Asp His Leu Asp His
    450                 455                 460                 
Met Thr Pro Glu Gln Ile Ala Trp Leu Lys Leu Gln Gln Glu Phe Tyr
465                 470                 475                 480 
Glu Glu Lys Arg Arg Lys Gln Glu Gln Val Val Val Gln Gln Cys Ser
                485                 490                 495     
Leu Gln Asp Met Met Val His Gln His Gly Pro Arg Gly Val Val Arg
            500                 505                 510         
Gly Pro Pro Pro Pro Tyr Gln Met Thr Pro Ser Glu Gly Trp Ala Pro
        515                 520                 525             
Gly Gly Thr Glu Pro Phe Ser Asp Gly Ile Asn Met Pro His Ser Leu
    530                 535                 540                 
Pro Pro Arg Gly Met Ala Pro His Pro Asn Met Pro Gly Ser Gln Met
545                 550                 555                 560 
Arg Leu Pro Gly Phe Ala Gly Met Ile Asn Ser Glu Met Glu Gly Pro
                565                 570                 575     
Asn Val Pro Asn Pro Ala Ser Arg Pro Gly Leu Ser Gly Val Ser Trp
            580                 585                 590         
Pro Asp Asp Val Pro Lys Ile Pro Asp Gly Arg Asn Phe Pro Pro Gly
        595                 600                 605             
Gln Gly Ile Phe Ser Gly Pro Gly Arg Gly Glu Arg Phe Pro Asn Pro
    610                 615                 620                 
Gln Gly Leu Ser Glu Glu Met Phe Gln Gln Gln Leu Ala Glu Lys Gln
625                 630                 635                 640 
Leu Gly Leu Pro Pro Gly Met Ala Met Glu Gly Ile Arg Pro Ser Met
                645                 650                 655     
Glu Met Asn Arg Met Ile Pro Gly Ser Gln Arg His Met Glu Pro Gly
            660                 665                 670         
Asn Asn Pro Ile Phe Pro Arg Ile Pro Val Glu Gly Pro Leu Ser Pro
        675                 680                 685             
Ser Arg Gly Asp Phe Pro Lys Gly Ile Pro Pro Gln Met Gly Pro Gly
    690                 695                 700                 
Arg Glu Leu Glu Phe Gly Met Val Pro Ser Gly Met Lys Gly Asp Val
705                 710                 715                 720 
Asn Leu Asn Val Asn Met Gly Ser Asn Ser Gln Met Ile Pro Gln Lys
                725                 730                 735     
Met Arg Glu Ala Gly Ala Gly Pro Glu Glu Met Leu Lys Leu Arg Pro
            740                 745                 750         
Gly Gly Ser Asp Met Leu Pro Ala Gln Gln Lys Met Val Pro Leu Pro
        755                 760                 765             
Phe Gly Glu His Pro Gln Gln Glu Tyr Gly Met Gly Pro Arg Pro Phe
    770                 775                 780                 
Leu Pro Met Ser Gln Gly Pro Gly Ser Asn Ser Gly Leu Arg Asn Leu
785                 790                 795                 800 
Arg Glu Pro Ile Gly Pro Asp Gln Arg Thr Asn Ser Arg Leu Ser His
                805                 810                 815     
Met Pro Pro Leu Pro Leu Asn Pro Ser Ser Asn Pro Thr Ser Leu Asn
            820                 825                 830         
Thr Ala Pro Pro Val Gln Arg Gly Leu Gly Arg Lys Pro Leu Asp Ile
        835                 840                 845             
Ser Val Ala Gly Ser Gln Val His Ser Pro Gly Ile Asn Pro Leu Lys
    850                 855                 860                 
Ser Pro Thr Met His Gln Val Gln Ser Pro Met Leu Gly Ser Pro Ser
865                 870                 875                 880 
Gly Asn Leu Lys Ser Pro Gln Thr Pro Ser Gln Leu Ala Gly Met Leu
                885                 890                 895     
Ala Gly Pro Ala Ala Ala Ala Ser Ile Lys Ser Pro Pro Val Leu Gly
            900                 905                 910         
Ser Ala Ala Ala Ser Pro Val His Leu Lys Ser Pro Ser Leu Pro Ala
        915                 920                 925             
Pro Ser Pro Gly Trp Thr Ser Ser Pro Lys Pro Pro Leu Gln Ser Pro
    930                 935                 940                 
Gly Ile Pro Pro Asn His Lys Ala Pro Leu Thr Met Ala Ser Pro Ala
945                 950                 955                 960 
Met Leu Gly Asn Val Glu Ser Gly Gly Pro Pro Pro Pro Thr Ala Ser
                965                 970                 975     
Gln Pro Ala Ser Val Asn Ile Pro Gly Ser Leu Pro Ser Ser Thr Pro
            980                 985                 990         
Tyr Thr Met Pro Pro Glu Pro Thr Leu Ser Gln Asn Pro Leu Ser Ile
        995                 1000                1005            
Met Met Ser Arg Met Ser Lys Phe Ala Met Pro Ser Ser Thr Pro Leu
    1010                1015                1020                
Tyr His Asp Ala Ile Lys Thr Val Ala Ser Ser Asp Asp Asp Ser Pro
1025                1030                1035                1040
Pro Ala Arg Ser Pro Asn Leu Pro Ser Met Asn Asn Met Pro Gly Met
                1045                1050                1055    
Gly Ile Asn Thr Gln Asn Pro Arg Ile Ser Gly Pro Asn Pro Val Val
            1060                1065                1070        
Pro Met Pro Thr Leu Ser Pro Met Gly Met Thr Gln Pro Leu Ser His
        1075                1080                1085            
Ser Asn Gln Met Pro Ser Pro Asn Ala Val Gly Pro Asn Ile Pro Pro
    1090                1095                1100                
His Gly Val Pro Met Gly Pro Gly Leu Met Ser His Asn Pro Ile Met
1105                1110                1115                1120
Gly His Gly Ser Gln Glu Pro Pro Met Val Pro Gln Gly Arg Met Gly
                1125                1130                1135    
Phe Pro Gln Gly Phe Pro Pro Val Gln Ser Pro Pro Gln Gln Val Pro
            1140                1145                1150        
Phe Pro His Asn Gly Pro Ser Gly Gly Gln Gly Ser Phe Pro Gly Gly
        1155                1160                1165            
Met Gly Phe Pro Gly Glu Gly Pro Leu Gly Arg Pro Ser Asn Leu Pro
    1170                1175                1180                
Gln Ser Ser Ala Asp Ala Ala Leu Cys Lys Pro Gly Gly Pro Gly Gly
1185                1190                1195                1200
Pro Asp Ser Phe Thr Val Leu Gly Asn Ser Met Pro Ser Val Phe Thr
                1205                1210                1215    
Asp Pro Asp Leu Gln Glu Val Ile Arg Pro Gly Ala Thr Gly Ile Pro
            1220                1225                1230        
Glu Phe Asp Leu Ser Arg Ile Ile Pro Ser Glu Lys Pro Ser Gln Thr
        1235                1240                1245            
Leu Gln Tyr Phe Pro Arg Gly Glu Val Pro Gly Arg Lys Gln Pro Gln
    1250                1255                1260                
Gly Pro Gly Pro Gly Phe Ser His Met Gln Gly Met Met Gly Glu Gln
1265                1270                1275                1280
Ala Pro Arg Met Gly Leu Ala Leu Pro Gly Met Gly Gly Pro Gly Pro
                1285                1290                1295    
Val Gly Thr Pro Asp Ile Pro Leu Gly Thr Ala Pro Ser Met Pro Gly
            1300                1305                1310        
His Asn Pro Met Arg Pro Pro Ala Phe Leu Gln Gln Gly Met Met Gly
        1315                1320                1325            
Pro His His Arg Met Met Ser Pro Ala Gln Ser Thr Met Pro Gly Gln
    1330                1335                1340                
Pro Thr Leu Met Ser Asn Pro Ala Ala Ala Val Gly Met Ile Pro Gly
1345                1350                1355                1360
Lys Asp Arg Gly Pro Ala Gly Leu Tyr Thr His Pro Gly Pro Val Gly
                1365                1370                1375    
Ser Pro Gly Met Met Met Ser Met Gln Gly Met Met Gly Pro Gln Gln
            1380                1385                1390        
Asn Ile Met Ile Pro Pro Gln Met Arg Pro Arg Gly Met Ala Ala Asp
        1395                1400                1405            
Val Gly Met Gly Gly Phe Ser Gln Gly Pro Gly Asn Pro Gly Asn Met
    1410                1415                1420                
Met Phe
1425    


<210> 1959
<211> 286
<212> PRT
<213> Homo sapiens

<400> 1959
Met Met Asp Lys Tyr Pro Glu Met Val Ser Arg Ile Lys Ile Gly Ser
 1               5                  10                  15      
Thr Val Glu Asp Asn Pro Leu Tyr Val Leu Lys Ile Gly Glu Lys Asn
            20                  25                  30          
Glu Arg Arg Lys Ala Ile Phe Thr Asp Cys Gly Ile His Ala Arg Glu
        35                  40                  45              
Trp Val Ser Pro Ala Phe Cys Gln Trp Phe Val Tyr Gln Ala Thr Lys
    50                  55                  60                  
Thr Tyr Gly Arg Asn Lys Ile Met Thr Lys Leu Leu Asp Arg Met Asn
65                  70                  75                  80  
Phe Tyr Ile Leu Pro Val Phe Asn Val Asp Gly Tyr Ile Trp Ser Trp
                85                  90                  95      
Thr Lys Asn Arg Met Trp Arg Lys Asn Arg Ser Lys Asn Gln Asn Ser
            100                 105                 110         
Lys Cys Ile Gly Thr Asp Leu Asn Arg Asn Phe Asn Ala Ser Trp Asn
        115                 120                 125             
Ser Ile Pro Asn Thr Asn Asp Pro Cys Ala Asp Asn Tyr Arg Gly Ser
    130                 135                 140                 
Ala Pro Glu Ser Glu Lys Glu Thr Lys Ala Val Thr Asn Phe Ile Arg
145                 150                 155                 160 
Ser His Leu Asn Glu Ile Lys Val Tyr Ile Thr Phe His Ser Tyr Ser
                165                 170                 175     
Gln Met Leu Leu Phe Pro Tyr Gly Tyr Thr Ser Lys Leu Pro Pro Asn
            180                 185                 190         
His Glu Asp Leu Ala Lys Val Ala Lys Ile Gly Thr Asp Val Leu Ser
        195                 200                 205             
Thr Arg Tyr Glu Thr Arg Tyr Ile Tyr Gly Pro Ile Glu Ser Thr Ile
    210                 215                 220                 
Tyr Pro Ile Ser Gly Ser Ser Leu Asp Trp Ala Tyr Asp Leu Gly Ile
225                 230                 235                 240 
Lys His Thr Phe Ala Phe Glu Leu Arg Asp Lys Gly Lys Phe Gly Phe
                245                 250                 255     
Leu Leu Pro Glu Ser Arg Ile Lys Pro Thr Cys Arg Glu Thr Met Leu
            260                 265                 270         
Ala Val Lys Phe Ile Ala Lys Tyr Ile Leu Lys His Thr Ser
        275                 280                 285     


<210> 1960
<211> 482
<212> PRT
<213> Homo sapiens

<400> 1960
Met Ala Ala Val Arg Met Leu Arg Thr Trp Ser Arg Asn Ala Gly Lys
 1               5                  10                  15      
Leu Ile Cys Val Arg Tyr Phe Gln Thr Cys Gly Asn Val His Val Leu
            20                  25                  30          
Lys Pro Asn Tyr Val Cys Phe Phe Gly Tyr Pro Ser Phe Lys Tyr Ser
        35                  40                  45              
His Pro His His Phe Leu Lys Thr Thr Ala Ala Leu Arg Gly Gln Val
    50                  55                  60                  
Val Gln Phe Lys Leu Ser Asp Ile Gly Glu Gly Ile Arg Glu Val Thr
65                  70                  75                  80  
Val Lys Glu Trp Tyr Val Lys Glu Gly Asp Thr Val Ser Gln Phe Asp
                85                  90                  95      
Ser Ile Cys Glu Val Gln Ser Asp Lys Ala Ser Val Thr Ile Thr Ser
            100                 105                 110         
Arg Tyr Asp Gly Val Ile Lys Lys Leu Tyr Tyr Asn Leu Asp Asp Ile
        115                 120                 125             
Ala Tyr Val Gly Lys Pro Leu Val Asp Ile Glu Thr Glu Ala Leu Lys
    130                 135                 140                 
Asp Ser Glu Glu Asp Val Val Glu Thr Pro Ala Val Ser His Asp Glu
145                 150                 155                 160 
His Thr His Gln Glu Ile Lys Gly Arg Lys Thr Leu Ala Thr Pro Ala
                165                 170                 175     
Val Arg Arg Leu Ala Met Glu Asn Asn Ile Lys Leu Ser Glu Val Val
            180                 185                 190         
Gly Ser Gly Lys Asp Gly Arg Ile Leu Lys Glu Asp Ile Leu Asn Tyr
        195                 200                 205             
Leu Glu Lys Gln Thr Gly Ala Ile Leu Pro Pro Ser Pro Lys Val Glu
    210                 215                 220                 
Ile Met Pro Pro Pro Pro Lys Pro Lys Asp Met Thr Val Pro Ile Leu
225                 230                 235                 240 
Val Ser Lys Pro Pro Val Phe Thr Gly Lys Asp Lys Thr Glu Pro Ile
                245                 250                 255     
Lys Gly Phe Gln Lys Ala Met Val Lys Thr Met Ser Ala Ala Leu Lys
            260                 265                 270         
Ile Pro His Phe Gly Tyr Cys Asp Glu Ile Asp Leu Thr Glu Leu Val
        275                 280                 285             
Lys Leu Arg Glu Glu Leu Lys Pro Ile Ala Phe Ala Arg Gly Ile Lys
    290                 295                 300                 
Leu Ser Phe Met Pro Phe Phe Leu Lys Ala Ala Ser Leu Gly Leu Leu
305                 310                 315                 320 
Gln Phe Pro Ile Leu Asn Ala Ser Val Asp Glu Asn Cys Gln Asn Ile
                325                 330                 335     
Thr Tyr Lys Ala Ser His Asn Ile Gly Ile Ala Met Asp Thr Glu Gln
            340                 345                 350         
Gly Leu Ile Val Pro Asn Val Lys Asn Val Gln Ile Cys Ser Ile Phe
        355                 360                 365             
Asp Ile Ala Thr Glu Leu Asn Arg Leu Gln Lys Leu Gly Ser Val Ser
    370                 375                 380                 
Gln Leu Ser Thr Thr Asp Leu Thr Gly Gly Thr Phe Thr Leu Ser Asn
385                 390                 395                 400 
Ile Gly Ser Ile Gly Gly Thr Phe Ala Lys Pro Val Ile Met Pro Pro
                405                 410                 415     
Glu Val Ala Ile Gly Ala Leu Gly Ser Ile Lys Ala Ile Pro Arg Phe
            420                 425                 430         
Asn Gln Lys Gly Glu Val Tyr Lys Ala Gln Ile Met Asn Val Ser Trp
        435                 440                 445             
Ser Ala Asp His Arg Val Ile Asp Gly Ala Thr Met Ser Arg Phe Ser
    450                 455                 460                 
Asn Leu Trp Lys Ser Tyr Leu Glu Asn Pro Ala Phe Met Leu Leu Asp
465                 470                 475                 480 
Leu Lys
        


<210> 1961
<211> 1093
<212> PRT
<213> Homo sapiens

<400> 1961
Met Ser Trp Phe Asn Ala Ser Gln Leu Ser Ser Phe Ala Lys Gln Ala
 1               5                  10                  15      
Leu Ser Gln Ala Gln Lys Ser Ile Asp Arg Val Leu Asp Ile Gln Glu
            20                  25                  30          
Glu Glu Pro Ser Ile Trp Ala Glu Thr Ile Pro Tyr Gly Glu Pro Gly
        35                  40                  45              
Ile Ser Ser Pro Val Ser Gly Gly Trp Asp Thr Ser Thr Trp Gly Leu
    50                  55                  60                  
Lys Ser Asn Thr Glu Pro Gln Ser Pro Pro Ile Ala Ser Pro Lys Ala
65                  70                  75                  80  
Ile Thr Lys Pro Val Arg Arg Thr Val Val Asp Glu Ser Glu Asn Phe
                85                  90                  95      
Phe Ser Ala Phe Leu Ser Pro Thr Asp Val Gln Thr Ile Gln Lys Ser
            100                 105                 110         
Pro Val Val Ser Lys Pro Pro Ala Lys Ser Gln Arg Pro Glu Glu Glu
        115                 120                 125             
Val Lys Ser Ser Leu His Glu Ser Leu His Ile Gly Gln Ser Arg Thr
    130                 135                 140                 
Pro Glu Thr Thr Glu Ser Gln Val Lys Asp Ser Ser Leu Cys Val Ser
145                 150                 155                 160 
Gly Glu Thr Leu Ala Ala Gly Thr Ser Ser Pro Lys Thr Glu Gly Lys
                165                 170                 175     
His Glu Glu Thr Val Asn Lys Glu Ser Asp Met Lys Val Pro Thr Val
            180                 185                 190         
Ser Leu Lys Val Ser Glu Ser Val Ile Asp Val Lys Thr Thr Met Glu
        195                 200                 205             
Ser Ile Ser Asn Thr Ser Thr Gln Ser Leu Thr Ala Glu Thr Lys Asp
    210                 215                 220                 
Ile Ala Leu Glu Pro Lys Glu Gln Lys His Glu Asp Arg Gln Ser Asn
225                 230                 235                 240 
Thr Pro Ser Pro Pro Val Ser Thr Phe Ser Ser Gly Thr Ser Thr Thr
                245                 250                 255     
Ser Asp Ile Glu Val Leu Asp His Glu Ser Val Ile Ser Glu Ser Ser
            260                 265                 270         
Ala Ser Ser Arg Gln Glu Thr Thr Asp Ser Lys Ser Ser Leu His Leu
        275                 280                 285             
Met Gln Thr Ser Phe Gln Leu Leu Ser Ala Ser Ala Cys Pro Glu Tyr
    290                 295                 300                 
Asn Arg Leu Asp Asp Phe Gln Lys Leu Thr Glu Ser Cys Cys Ser Ser
305                 310                 315                 320 
Asp Ala Phe Glu Arg Ile Asp Ser Phe Ser Val Gln Ser Leu Asp Ser
                325                 330                 335     
Arg Ser Val Ser Glu Ile Asn Ser Asp Asp Glu Leu Ser Gly Lys Gly
            340                 345                 350         
Tyr Ala Leu Val Pro Ile Ile Val Asn Ser Ser Thr Pro Lys Ser Lys
        355                 360                 365             
Thr Val Glu Ser Ala Glu Gly Lys Ser Glu Glu Val Asn Glu Thr Leu
    370                 375                 380                 
Val Ile Pro Thr Glu Glu Ala Glu Met Glu Glu Ser Gly Arg Ser Ala
385                 390                 395                 400 
Thr Pro Val Asn Cys Glu Gln Pro Asp Ile Leu Val Ser Ser Thr Pro
                405                 410                 415     
Ile Asn Glu Gly Gln Thr Val Leu Asp Lys Val Ala Glu Gln Cys Glu
            420                 425                 430         
Pro Ala Glu Ser Gln Pro Glu Ala Leu Ser Glu Lys Glu Asp Val Cys
        435                 440                 445             
Lys Thr Val Glu Phe Leu Asn Glu Lys Leu Glu Lys Arg Glu Ala Gln
    450                 455                 460                 
Leu Leu Ser Leu Ser Lys Glu Lys Ala Leu Leu Glu Glu Ala Phe Asp
465                 470                 475                 480 
Asn Leu Lys Asp Glu Met Phe Arg Val Lys Glu Glu Ser Ser Ser Ile
                485                 490                 495     
Ser Ser Leu Lys Asp Glu Phe Thr Gln Arg Ile Ala Glu Ala Glu Lys
            500                 505                 510         
Lys Val Gln Leu Ala Cys Lys Glu Arg Asp Ala Ala Lys Lys Glu Ile
        515                 520                 525             
Lys Asn Ile Lys Glu Glu Leu Ala Thr Arg Leu Asn Ser Ser Glu Thr
    530                 535                 540                 
Ala Asp Leu Leu Lys Glu Lys Asp Glu Gln Ile Arg Gly Leu Met Glu
545                 550                 555                 560 
Glu Gly Glu Lys Leu Ser Lys Gln Gln Leu His Asn Ser Asn Ile Ile
                565                 570                 575     
Lys Lys Leu Arg Ala Lys Asp Lys Glu Asn Glu Asn Met Val Ala Lys
            580                 585                 590         
Leu Asn Lys Lys Val Lys Glu Leu Glu Glu Glu Leu Gln His Leu Lys
        595                 600                 605             
Gln Val Leu Asp Gly Lys Glu Glu Val Glu Lys Gln His Arg Glu Asn
    610                 615                 620                 
Ile Lys Lys Leu Asn Ser Met Val Glu Arg Gln Glu Lys Asp Leu Gly
625                 630                 635                 640 
Arg Leu Gln Val Asp Met Asp Glu Leu Glu Glu Lys Asn Arg Ser Ile
                645                 650                 655     
Gln Ala Ala Leu Asp Ser Ala Tyr Lys Glu Leu Thr Asp Leu His Lys
            660                 665                 670         
Ala Asn Ala Ala Lys Asp Ser Glu Ala Gln Glu Ala Ala Leu Ser Arg
        675                 680                 685             
Glu Met Lys Ala Lys Glu Glu Leu Ser Ala Ala Leu Glu Lys Ala Gln
    690                 695                 700                 
Glu Glu Ala Arg Gln Gln Gln Glu Thr Leu Ala Ile Gln Val Gly Asp
705                 710                 715                 720 
Leu Arg Leu Ala Leu Gln Arg Thr Glu Gln Ala Ala Ala Arg Lys Glu
                725                 730                 735     
Asp Tyr Leu Arg His Glu Ile Gly Glu Leu Gln Gln Arg Leu Gln Glu
            740                 745                 750         
Ala Glu Asn Arg Asn Gln Glu Leu Ser Gln Ser Val Ser Ser Thr Thr
        755                 760                 765             
Arg Pro Leu Leu Arg Gln Ile Glu Asn Leu Gln Ala Thr Leu Gly Ser
    770                 775                 780                 
Gln Thr Ser Ser Trp Glu Lys Leu Glu Lys Asn Leu Ser Asp Arg Leu
785                 790                 795                 800 
Gly Glu Ser Gln Thr Leu Leu Ala Ala Ala Val Glu Arg Glu Arg Ala
                805                 810                 815     
Ala Thr Glu Glu Leu Leu Ala Asn Lys Ile Gln Met Ser Ser Met Glu
            820                 825                 830         
Ser Gln Asn Ser Leu Leu Arg Gln Glu Asn Ser Arg Phe Gln Ala Gln
        835                 840                 845             
Leu Glu Ser Glu Lys Asn Arg Leu Cys Lys Leu Glu Asp Glu Asn Asn
    850                 855                 860                 
Arg Tyr Gln Val Glu Leu Glu Asn Leu Lys Asp Glu Tyr Val Arg Thr
865                 870                 875                 880 
Leu Glu Glu Thr Arg Lys Glu Lys Thr Leu Leu Asn Ser Gln Leu Glu
                885                 890                 895     
Met Glu Arg Met Lys Val Glu Gln Glu Arg Lys Lys Ala Ile Phe Thr
            900                 905                 910         
Gln Glu Thr Ile Lys Glu Lys Glu Arg Lys Pro Phe Ser Val Ser Ser
        915                 920                 925             
Thr Pro Thr Met Ser Arg Ser Ser Ser Ile Ser Gly Val Asp Met Ala
    930                 935                 940                 
Gly Leu Gln Thr Ser Phe Leu Ser Gln Asp Glu Ser His Asp His Ser
945                 950                 955                 960 
Phe Gly Pro Met Pro Ile Ser Ala Asn Gly Ser Asn Leu Tyr Asp Ala
                965                 970                 975     
Val Arg Met Gly Ala Gly Ser Ser Ile Ile Glu Asn Leu Gln Ser Gln
            980                 985                 990         
Leu Lys Leu Arg Glu Gly Glu Ile Thr His Leu Gln Leu Glu Ile Gly
        995                 1000                1005            
Asn Leu Glu Lys Thr Arg Ser Ile Met Ala Glu Glu Leu Val Lys Leu
    1010                1015                1020                
Thr Asn Gln Asn Asp Glu Leu Glu Glu Lys Val Lys Glu Ile Pro Lys
1025                1030                1035                1040
Leu Arg Thr Gln Leu Arg Asp Leu Asp Gln Arg Tyr Asn Thr Ile Leu
                1045                1050                1055    
Gln Met Tyr Gly Glu Lys Ala Glu Glu Ala Glu Glu Leu Arg Leu Asp
            1060                1065                1070        
Leu Glu Asp Val Lys Asn Met Tyr Lys Thr Gln Ile Asp Glu Leu Leu
        1075                1080                1085            
Arg Gln Ser Leu Ser
    1090            


<210> 1962
<211> 94
<212> PRT
<213> Homo sapiens

<400> 1962
Met Cys Thr Gly Ala Leu Arg Val Arg Tyr Thr Ala Cys Ser Ile Val
 1               5                  10                  15      
Trp Ile His Leu Thr Ala Gln Asp Arg Ser Ile Arg Ser Leu Phe Trp
            20                  25                  30          
His Leu Leu Asp Trp Gly Glu Gln Arg Ala Arg Gln Gln Ala Arg Gly
        35                  40                  45              
Arg Arg Gln Lys Glu Thr Pro Arg Arg Gly Glu Ala Gln Gly Leu Arg
    50                  55                  60                  
Lys Ala Asp Ser Ser Leu Gln Lys Ser Leu Pro Ser Lys Ala Pro Val
65                  70                  75                  80  
Leu Trp Ala Gly Arg Gly Gly Cys Lys Leu Arg Arg Gly His
                85                  90                  


<210> 1963
<211> 602
<212> PRT
<213> Homo sapiens

<400> 1963
Met Pro Arg Asn Gln Gly Phe Ser Glu Pro Glu Tyr Ser Ala Glu Tyr
 1               5                  10                  15      
Ser Ala Glu Tyr Ser Val Ser Leu Pro Ser Asp Pro Asp Arg Gly Val
            20                  25                  30          
Gly Arg Thr His Glu Ile Ser Val Arg Asn Ser Gly Ser Cys Leu Cys
        35                  40                  45              
Leu Pro Arg Phe Met Arg Leu Thr Phe Val Pro Glu Ser Leu Glu Asn
    50                  55                  60                  
Leu Tyr Gln Thr Tyr Phe Lys Arg Gln Arg His Glu Thr Leu Leu Val
65                  70                  75                  80  
Leu Val Val Phe Ala Ala Leu Phe Asp Cys Tyr Val Val Val Met Cys
                85                  90                  95      
Ala Val Val Phe Ser Ser Asp Lys Leu Ala Ser Leu Ala Val Ala Gly
            100                 105                 110         
Ile Gly Leu Val Leu Asp Ile Ile Leu Phe Val Leu Cys Lys Lys Gly
        115                 120                 125             
Leu Leu Pro Asp Arg Val Thr Arg Arg Val Leu Leu Tyr Val Leu Trp
    130                 135                 140                 
Leu Leu Ile Thr Ala Gln Ile Phe Ser Tyr Leu Gly Leu Asn Phe Ala
145                 150                 155                 160 
Arg Ala His Ala Ala Ser Asp Thr Val Gly Trp Gln Val Phe Phe Val
                165                 170                 175     
Phe Ser Phe Phe Ile Thr Leu Pro Leu Ser Leu Ser Pro Ile Val Ile
            180                 185                 190         
Ile Ser Val Val Ser Cys Val Val His Thr Leu Val Leu Gly Val Thr
        195                 200                 205             
Val Ala Gln Gln Gln Gln Glu Glu Leu Lys Gly Met Gln Leu Leu Arg
    210                 215                 220                 
Glu Ile Leu Ala Asn Val Phe Leu Tyr Leu Cys Ala Ile Ala Val Gly
225                 230                 235                 240 
Ile Met Ser Tyr Tyr Met Ala Asp Arg Lys His Arg Lys Ala Phe Leu
                245                 250                 255     
Glu Ala Arg Gln Ser Leu Glu Val Lys Met Asn Leu Glu Glu Gln Ser
            260                 265                 270         
Gln Gln Gln Glu Asn Leu Met Leu Ser Ile Leu Pro Lys His Val Ala
        275                 280                 285             
Asp Glu Met Leu Lys Asp Met Lys Lys Asp Glu Ser Gln Lys Asp Gln
    290                 295                 300                 
Gln Gln Phe Asn Thr Met Tyr Met Tyr Arg His Glu Asn Val Ser Ile
305                 310                 315                 320 
Leu Phe Ala Asp Ile Val Gly Phe Thr Gln Leu Ser Ser Ala Cys Ser
                325                 330                 335     
Ala Gln Glu Leu Val Lys Leu Leu Asn Glu Leu Phe Ala Arg Phe Asp
            340                 345                 350         
Lys Leu Ala Ala Lys Tyr His Gln Leu Arg Ile Lys Ile Leu Gly Asp
        355                 360                 365             
Cys Tyr Tyr Cys Ile Cys Gly Leu Pro Asp Tyr Arg Glu Asp His Ala
    370                 375                 380                 
Val Cys Ser Ile Leu Met Gly Leu Ala Met Val Glu Ala Ile Ser Tyr
385                 390                 395                 400 
Val Arg Glu Lys Thr Lys Thr Gly Val Asp Met Arg Val Gly Val His
                405                 410                 415     
Thr Gly Thr Val Leu Gly Gly Val Leu Gly Gln Lys Arg Trp Gln Tyr
            420                 425                 430         
Asp Val Trp Ser Thr Asp Val Thr Val Ala Asn Lys Met Glu Ala Gly
        435                 440                 445             
Gly Ile Pro Gly Arg Val His Ile Ser Gln Ser Thr Met Asp Cys Leu
    450                 455                 460                 
Lys Gly Glu Phe Asp Val Glu Pro Gly Asp Gly Gly Ser Arg Cys Asp
465                 470                 475                 480 
Tyr Leu Glu Glu Lys Gly Ile Glu Thr Tyr Leu Ile Ile Ala Ser Lys
                485                 490                 495     
Pro Glu Val Lys Lys Thr Ala Thr Gln Asn Gly Leu Asn Gly Ser Ala
            500                 505                 510         
Leu Pro Asn Gly Ala Pro Ala Ser Ser Lys Ser Ser Ser Pro Ala Leu
        515                 520                 525             
Ile Glu Thr Lys Glu Pro Asn Gly Ser Ala His Ser Ser Gly Ser Thr
    530                 535                 540                 
Ser Glu Lys Pro Glu Glu Gln Asp Ala Gln Ala Asp Asn Pro Ser Phe
545                 550                 555                 560 
Pro Asn Pro Arg Arg Arg Leu Arg Leu Gln Asp Leu Ala Asp Arg Val
                565                 570                 575     
Val Asp Ala Ser Glu Asp Glu His Glu Leu Asn Gln Leu Leu Asn Glu
            580                 585                 590         
Ala Leu Leu Glu Arg Glu Ser Ala Gln Val
        595                 600         


<210> 1964
<211> 1243
<212> PRT
<213> Homo sapiens

<400> 1964
Met Leu Ile His Pro Pro Asp Glu Pro Gly Thr Glu Asn Gln Glu Ala
 1               5                  10                  15      
Cys Gln Arg Tyr Glu Val Met Gln Cys Phe Thr Val Ser Gln Pro Lys
            20                  25                  30          
Ser Ile Gln Glu Asp Gly Glu Asp Phe Gln Ser Cys Leu Ile Cys Ile
        35                  40                  45              
Ala Arg Arg Leu Pro Arg Pro Pro Ala Ile Thr Gly Val Glu Ser Phe
    50                  55                  60                  
Met Thr Lys Gln Asp Thr Thr Gly Lys Ile Ile Ser Ile Asp Thr Ser
65                  70                  75                  80  
Ser Leu Arg Ala Ala Gly Arg Thr Gly Trp Glu Asp Leu Val Arg Lys
                85                  90                  95      
Cys Ile Tyr Ala Phe Phe Gln Pro Gln Gly Arg Glu Pro Ser Tyr Ala
            100                 105                 110         
Arg Gln Leu Phe Gln Glu Val Met Thr Arg Gly Thr Ala Ser Ser Pro
        115                 120                 125             
Ser Tyr Arg Phe Ile Leu Asn Asp Gly Thr Met Leu Ser Ala His Thr
    130                 135                 140                 
Lys Cys Lys Leu Cys Tyr Pro Gln Ser Pro Asp Met Gln Pro Phe Ile
145                 150                 155                 160 
Met Gly Ile His Ile Ile Asp Arg Glu His Ser Gly Leu Ser Pro Gln
                165                 170                 175     
Asp Asp Thr Asn Ser Gly Met Ser Ile Pro Arg Val Asn Pro Ser Val
            180                 185                 190         
Asn Pro Ser Ile Ser Pro Ala His Gly Val Ala Arg Ser Ser Thr Leu
        195                 200                 205             
Pro Pro Ser Asn Ser Asn Met Val Ser Thr Arg Ile Asn Arg Gln Gln
    210                 215                 220                 
Ser Ser Asp Leu His Ser Ser Ser His Ser Asn Ser Ser Asn Ser Gln
225                 230                 235                 240 
Gly Ser Phe Gly Cys Ser Pro Gly Ser Gln Ile Val Ala Asn Val Ala
                245                 250                 255     
Leu Asn Gln Gly Gln Ala Ser Ser Gln Ser Ser Asn Pro Ser Leu Asn
            260                 265                 270         
Leu Asn Asn Ser Pro Met Glu Gly Thr Gly Ile Ser Leu Ala Gln Phe
        275                 280                 285             
Met Ser Pro Arg Arg Gln Val Thr Ser Gly Leu Ala Thr Arg Pro Arg
    290                 295                 300                 
Met Pro Asn Asn Ser Phe Pro Pro Asn Ile Ser Thr Leu Ser Ser Pro
305                 310                 315                 320 
Val Gly Met Thr Ser Ser Ala Cys Asn Asn Asn Asn Arg Ser Tyr Ser
                325                 330                 335     
Asn Ile Pro Val Thr Ser Leu Gln Gly Met Asn Glu Gly Pro Asn Asn
            340                 345                 350         
Ser Val Gly Phe Ser Ala Ser Ser Pro Val Leu Arg Gln Met Ser Ser
        355                 360                 365             
Gln Asn Ser Pro Ser Arg Leu Asn Ile Gln Pro Ala Lys Ala Glu Ser
    370                 375                 380                 
Lys Asp Asn Lys Glu Ile Ala Ser Ile Leu Asn Glu Met Ile Gln Ser
385                 390                 395                 400 
Asp Asn Ser Ser Ser Asp Gly Lys Pro Leu Asp Ser Gly Leu Leu His
                405                 410                 415     
Asn Asn Asp Arg Leu Ser Asp Gly Asp Ser Lys Tyr Ser Gln Thr Ser
            420                 425                 430         
His Lys Leu Val Gln Leu Leu Thr Thr Thr Ala Glu Gln Gln Leu Arg
        435                 440                 445             
His Ala Asp Ile Asp Thr Ser Cys Lys Asp Val Leu Ser Cys Thr Gly
    450                 455                 460                 
Thr Ser Asn Ser Ala Ser Ala Asn Ser Ser Gly Gly Ser Cys Pro Ser
465                 470                 475                 480 
Ser His Ser Ser Leu Thr Glu Arg His Lys Ile Leu His Arg Leu Leu
                485                 490                 495     
Gln Glu Gly Ser Pro Ser Asp Ile Thr Thr Leu Ser Val Glu Pro Asp
            500                 505                 510         
Lys Lys Asp Ser Ala Ser Thr Ser Val Ser Val Thr Gly Gln Val Gln
        515                 520                 525             
Gly Asn Ser Ser Ile Lys Leu Glu Leu Asp Ala Ser Lys Lys Lys Glu
    530                 535                 540                 
Ser Lys Asp His Gln Leu Leu Arg Tyr Leu Leu Asp Lys Asp Glu Lys
545                 550                 555                 560 
Asp Leu Arg Ser Thr Pro Asn Leu Ser Leu Asp Asp Val Lys Val Lys
                565                 570                 575     
Val Glu Lys Lys Glu Gln Met Asp Pro Cys Asn Thr Asn Pro Thr Pro
            580                 585                 590         
Met Thr Lys Pro Thr Pro Glu Glu Ile Lys Leu Glu Ala Gln Ser Gln
        595                 600                 605             
Phe Thr Ala Asp Leu Asp Gln Phe Asp Gln Leu Leu Pro Thr Leu Glu
    610                 615                 620                 
Lys Ala Ala Gln Leu Pro Gly Leu Cys Glu Thr Asp Arg Met Asp Gly
625                 630                 635                 640 
Ala Val Thr Ser Val Thr Ile Lys Ser Glu Ile Leu Pro Ala Ser Leu
                645                 650                 655     
Gln Ser Ala Thr Ala Arg Pro Thr Ser Arg Leu Asn Arg Leu Pro Glu
            660                 665                 670         
Leu Glu Leu Glu Ala Ile Asp Asn Gln Phe Gly Gln Pro Gly Thr Gly
        675                 680                 685             
Asp Gln Ile Pro Trp Thr Asn Asn Thr Val Thr Ala Ile Asn Gln Ser
    690                 695                 700                 
Lys Ser Glu Asp Gln Cys Ile Ser Ser Gln Leu Asp Glu Leu Leu Cys
705                 710                 715                 720 
Pro Pro Thr Thr Val Glu Gly Arg Asn Asp Glu Lys Ala Leu Leu Glu
                725                 730                 735     
Gln Leu Val Ser Phe Leu Ser Gly Lys Asp Glu Thr Glu Leu Ala Glu
            740                 745                 750         
Leu Asp Arg Ala Leu Gly Ile Asp Lys Leu Val Gln Gly Gly Gly Leu
        755                 760                 765             
Asp Val Leu Ser Glu Arg Phe Pro Pro Gln Gln Ala Thr Pro Pro Leu
    770                 775                 780                 
Ile Met Glu Glu Arg Pro Asn Leu Tyr Ser Gln Pro Tyr Ser Ser Pro
785                 790                 795                 800 
Ser Pro Thr Ala Asn Leu Pro Ser Pro Phe Gln Gly Met Val Arg Gln
                805                 810                 815     
Lys Pro Ser Leu Gly Thr Met Pro Val Gln Val Thr Pro Pro Arg Gly
            820                 825                 830         
Ala Phe Ser Pro Gly Met Gly Met Gln Pro Arg Gln Thr Leu Asn Arg
        835                 840                 845             
Pro Pro Ala Ala Pro Asn Gln Leu Arg Leu Gln Leu Gln Gln Arg Leu
    850                 855                 860                 
Gln Gly Gln Gln Gln Leu Ile His Gln Asn Arg Gln Ala Ile Leu Asn
865                 870                 875                 880 
Gln Phe Ala Ala Thr Ala Pro Val Gly Ile Asn Met Arg Ser Gly Met
                885                 890                 895     
Gln Gln Gln Ile Thr Pro Gln Pro Pro Leu Asn Ala Gln Met Leu Ala
            900                 905                 910         
Gln Arg Gln Arg Glu Leu Tyr Ser Gln Gln His Arg Gln Arg Gln Leu
        915                 920                 925             
Ile Gln Gln Gln Arg Ala Met Leu Met Arg Gln Gln Ser Phe Gly Asn
    930                 935                 940                 
Asn Leu Pro Pro Ser Ser Gly Leu Pro Val Gln Met Gly Asn Pro Arg
945                 950                 955                 960 
Leu Pro Gln Gly Ala Pro Gln Gln Phe Pro Tyr Pro Pro Asn Tyr Gly
                965                 970                 975     
Thr Asn Pro Gly Thr Pro Pro Ala Ser Thr Ser Pro Phe Ser Gln Leu
            980                 985                 990         
Ala Ala Asn Pro Glu Ala Ser Leu Ala Asn Arg Asn Ser Met Val Ser
        995                 1000                1005            
Arg Gly Met Thr Gly Asn Ile Gly Gly Gln Phe Gly Thr Gly Ile Asn
    1010                1015                1020                
Pro Gln Met Gln Gln Asn Val Phe Gln Tyr Pro Gly Ala Gly Met Val
1025                1030                1035                1040
Pro Gln Gly Glu Ala Asn Phe Ala Pro Ser Leu Ser Pro Gly Ser Ser
                1045                1050                1055    
Met Val Pro Met Pro Ile Pro Pro Pro Gln Ser Ser Leu Leu Gln Gln
            1060                1065                1070        
Thr Pro Pro Ala Ser Gly Tyr Gln Ser Pro Asp Met Lys Ala Trp Gln
        1075                1080                1085            
Gln Gly Ala Ile Gly Asn Asn Asn Val Phe Ser Gln Ala Val Gln Asn
    1090                1095                1100                
Gln Pro Thr Pro Ala Gln Pro Gly Val Tyr Asn Asn Met Ser Ile Thr
1105                1110                1115                1120
Val Ser Met Ala Gly Gly Asn Thr Asn Val Gln Asn Met Asn Pro Met
                1125                1130                1135    
Met Ala Gln Met Gln Met Ser Ser Leu Gln Met Pro Gly Met Asn Thr
            1140                1145                1150        
Val Cys Pro Glu Gln Ile Asn Asp Pro Ala Leu Arg His Thr Gly Leu
        1155                1160                1165            
Tyr Cys Asn Gln Leu Ser Ser Thr Asp Leu Leu Lys Thr Glu Ala Asp
    1170                1175                1180                
Gly Thr Gln Gln Val Gln Gln Val Gln Val Phe Ala Asp Val Gln Cys
1185                1190                1195                1200
Thr Val Asn Leu Val Gly Gly Asp Pro Tyr Leu Asn Gln Pro Gly Pro
                1205                1210                1215    
Leu Gly Thr Gln Lys Pro Thr Ser Gly Pro Gln Thr Pro Gln Ala Gln
            1220                1225                1230        
Gln Lys Ser Leu Leu Gln Gln Leu Leu Thr Glu
        1235                1240            


<210> 1965
<211> 763
<212> PRT
<213> Homo sapiens

<400> 1965
Met Val Ala Cys Arg Ala Ile Gly Ile Leu Ser Arg Phe Ser Ala Phe
 1               5                  10                  15      
Arg Ile Leu Arg Ser Arg Gly Tyr Ile Cys Arg Asn Phe Thr Gly Ser
            20                  25                  30          
Ser Ala Leu Leu Thr Arg Thr His Ile Asn Tyr Gly Val Lys Gly Asp
        35                  40                  45              
Val Ala Val Val Arg Ile Asn Ser Pro Asn Ser Lys Val Asn Thr Leu
    50                  55                  60                  
Ser Lys Glu Leu His Ser Glu Phe Ser Glu Val Met Asn Glu Ile Trp
65                  70                  75                  80  
Ala Ser Asp Gln Ile Arg Ser Ala Val Leu Ile Ser Ser Lys Pro Gly
                85                  90                  95      
Cys Phe Ile Ala Gly Ala Asp Ile Asn Met Leu Ala Ala Cys Lys Thr
            100                 105                 110         
Leu Gln Glu Val Thr Gln Leu Ser Gln Glu Ala Gln Arg Ile Val Glu
        115                 120                 125             
Lys Leu Glu Lys Ser Thr Lys Pro Ile Val Ala Ala Ile Asn Gly Ser
    130                 135                 140                 
Cys Leu Gly Gly Gly Leu Glu Val Ala Ile Ser Cys Gln Tyr Arg Ile
145                 150                 155                 160 
Ala Thr Lys Asp Arg Lys Thr Val Leu Gly Thr Pro Glu Val Leu Leu
                165                 170                 175     
Gly Ala Leu Pro Gly Ala Gly Gly Thr Gln Arg Leu Pro Lys Met Val
            180                 185                 190         
Gly Val Pro Ala Ala Leu Asp Met Met Leu Thr Gly Arg Ser Ile Arg
        195                 200                 205             
Ala Asp Arg Ala Lys Lys Met Gly Leu Val Asp Gln Leu Val Glu Pro
    210                 215                 220                 
Leu Gly Pro Gly Leu Lys Pro Pro Glu Glu Arg Thr Ile Glu Tyr Leu
225                 230                 235                 240 
Glu Glu Val Ala Ile Thr Phe Ala Lys Gly Leu Ala Asp Lys Lys Ile
                245                 250                 255     
Ser Pro Lys Arg Asp Lys Gly Leu Val Glu Lys Leu Thr Ala Tyr Ala
            260                 265                 270         
Met Thr Ile Pro Phe Val Arg Gln Gln Val Tyr Lys Lys Val Glu Glu
        275                 280                 285             
Lys Val Arg Lys Gln Thr Lys Gly Leu Tyr Pro Ala Pro Leu Lys Ile
    290                 295                 300                 
Ile Asp Val Val Lys Thr Gly Ile Glu Gln Gly Ser Asp Ala Gly Tyr
305                 310                 315                 320 
Leu Cys Glu Ser Gln Lys Phe Gly Glu Leu Val Met Thr Lys Glu Ser
                325                 330                 335     
Lys Ala Leu Met Gly Leu Tyr His Gly Gln Val Leu Cys Lys Lys Asn
            340                 345                 350         
Lys Phe Gly Ala Pro Gln Lys Asp Val Lys His Leu Ala Ile Leu Gly
        355                 360                 365             
Ala Gly Leu Met Gly Ala Gly Ile Ala Gln Val Ser Val Asp Lys Gly
    370                 375                 380                 
Leu Lys Thr Ile Leu Lys Asp Ala Thr Leu Thr Ala Leu Asp Arg Gly
385                 390                 395                 400 
Gln Gln Gln Val Phe Lys Gly Leu Asn Asp Lys Val Lys Lys Lys Ala
                405                 410                 415     
Leu Thr Ser Phe Glu Arg Asp Ser Ile Phe Ser Asn Leu Thr Gly Gln
            420                 425                 430         
Leu Asp Tyr Gln Gly Phe Glu Lys Ala Asp Met Val Ile Glu Ala Val
        435                 440                 445             
Phe Glu Asp Leu Ser Leu Lys His Arg Val Leu Lys Glu Val Glu Ala
    450                 455                 460                 
Val Ile Pro Asp His Cys Ile Phe Ala Ser Asn Thr Ser Ala Leu Pro
465                 470                 475                 480 
Ile Ser Glu Ile Ala Ala Val Ser Lys Arg Pro Glu Lys Val Ile Gly
                485                 490                 495     
Met His Tyr Phe Ser Pro Val Asp Lys Met Gln Leu Leu Glu Ile Ile
            500                 505                 510         
Thr Thr Glu Lys Thr Ser Lys Asp Thr Ser Ala Ser Ala Val Ala Val
        515                 520                 525             
Gly Leu Lys Gln Gly Lys Val Ile Ile Val Val Lys Asp Gly Pro Gly
    530                 535                 540                 
Phe Tyr Thr Thr Arg Cys Leu Ala Pro Met Met Ser Glu Val Ile Arg
545                 550                 555                 560 
Ile Leu Gln Glu Gly Val Asp Pro Lys Lys Leu Asp Ser Leu Thr Thr
                565                 570                 575     
Ser Phe Gly Phe Pro Val Gly Ala Ala Thr Leu Val Asp Glu Val Gly
            580                 585                 590         
Val Asp Val Ala Lys His Val Ala Glu Asp Leu Gly Lys Val Phe Gly
        595                 600                 605             
Glu Arg Phe Gly Gly Gly Asn Pro Glu Leu Leu Thr Gln Met Val Ser
    610                 615                 620                 
Lys Gly Phe Leu Gly Arg Lys Ser Gly Lys Gly Phe Tyr Ile Tyr Gln
625                 630                 635                 640 
Glu Gly Val Lys Arg Lys Asp Leu Asn Ser Asp Met Asp Ser Ile Leu
                645                 650                 655     
Ala Ser Leu Lys Leu Pro Pro Lys Ser Glu Val Ser Ser Asp Glu Asp
            660                 665                 670         
Ile Gln Phe Arg Leu Val Thr Arg Phe Val Asn Glu Ala Val Met Cys
        675                 680                 685             
Leu Gln Glu Gly Ile Leu Ala Thr Pro Ala Glu Gly Asp Ile Gly Ala
    690                 695                 700                 
Val Phe Gly Leu Gly Phe Pro Pro Cys Leu Gly Gly Pro Phe Arg Phe
705                 710                 715                 720 
Val Asp Leu Tyr Gly Ala Gln Lys Ile Val Asp Arg Leu Lys Lys Tyr
                725                 730                 735     
Glu Ala Ala Tyr Gly Lys Gln Phe Thr Pro Cys Gln Leu Leu Ala Asp
            740                 745                 750         
His Ala Asn Ser Pro Asn Lys Lys Phe Tyr Gln
        755                 760             


<210> 1966
<211> 679
<212> PRT
<213> Homo sapiens

<400> 1966
Met Val Thr Ser Leu Asn Glu Asp Asn Glu Ser Val Thr Val Glu Trp
 1               5                  10                  15      
Ile Glu Asn Gly Asp Thr Lys Gly Lys Glu Ile Asp Leu Glu Ser Ile
            20                  25                  30          
Phe Ser Leu Asn Pro Asp Leu Val Pro Asp Glu Glu Ile Glu Pro Ser
        35                  40                  45              
Pro Glu Thr Pro Pro Pro Pro Ala Ser Ser Ala Lys Val Asn Lys Ile
    50                  55                  60                  
Val Lys Asn Arg Arg Thr Val Ala Ser Ile Lys Asn Asp Pro Pro Ser
65                  70                  75                  80  
Arg Asp Asn Arg Val Val Gly Ser Ala Arg Ala Arg Pro Ser Gln Phe
                85                  90                  95      
Pro Glu Gln Ser Ser Ser Ala Gln Gln Asn Gly Ser Val Ser Asp Ile
            100                 105                 110         
Ser Pro Val Gln Ala Ala Lys Lys Glu Phe Gly Pro Pro Ser Arg Arg
        115                 120                 125             
Lys Ser Asn Cys Val Lys Glu Val Glu Lys Leu Gln Glu Lys Arg Glu
    130                 135                 140                 
Lys Arg Arg Leu Gln Gln Gln Glu Leu Arg Glu Lys Arg Ala Gln Asp
145                 150                 155                 160 
Val Asp Ala Thr Asn Pro Asn Tyr Glu Ile Met Cys Met Ile Arg Asp
                165                 170                 175     
Phe Arg Gly Ser Leu Asp Tyr Arg Pro Leu Thr Thr Ala Asp Pro Ile
            180                 185                 190         
Asp Glu His Arg Ile Cys Val Cys Val Arg Lys Arg Pro Leu Asn Lys
        195                 200                 205             
Lys Glu Thr Gln Met Lys Asp Leu Asp Val Ile Thr Ile Pro Ser Lys
    210                 215                 220                 
Asp Val Val Met Val His Glu Pro Lys Gln Lys Val Asp Leu Thr Arg
225                 230                 235                 240 
Tyr Leu Glu Asn Gln Thr Phe Arg Phe Asp Tyr Ala Phe Asp Asp Ser
                245                 250                 255     
Ala Pro Asn Glu Met Val Tyr Arg Phe Thr Ala Arg Pro Leu Val Glu
            260                 265                 270         
Thr Ile Phe Glu Arg Gly Met Ala Thr Cys Phe Ala Tyr Gly Gln Thr
        275                 280                 285             
Gly Ser Gly Lys Thr His Thr Met Gly Gly Asp Phe Ser Gly Lys Asn
    290                 295                 300                 
Gln Asp Cys Ser Lys Gly Ile Tyr Ala Leu Ala Ala Arg Asp Val Phe
305                 310                 315                 320 
Leu Met Leu Lys Lys Pro Asn Tyr Lys Lys Leu Glu Leu Gln Val Tyr
                325                 330                 335     
Ala Thr Phe Phe Glu Ile Tyr Ser Gly Lys Val Phe Asp Leu Leu Asn
            340                 345                 350         
Arg Lys Thr Lys Leu Arg Val Leu Glu Asp Gly Lys Gln Gln Val Gln
        355                 360                 365             
Val Val Gly Leu Gln Glu Arg Glu Val Lys Cys Val Glu Asp Val Leu
    370                 375                 380                 
Lys Leu Ile Asp Ile Gly Asn Ser Cys Arg Thr Ser Gly Gln Thr Ser
385                 390                 395                 400 
Ala Asn Ala His Ser Ser Arg Ser His Ala Val Phe Gln Ile Ile Leu
                405                 410                 415     
Arg Arg Lys Gly Lys Leu His Gly Lys Phe Ser Leu Ile Asp Leu Ala
            420                 425                 430         
Gly Asn Glu Arg Gly Ala Asp Thr Ser Ser Ala Asp Arg Gln Thr Arg
        435                 440                 445             
Leu Glu Gly Ala Glu Ile Asn Lys Ser Leu Leu Ala Leu Lys Glu Cys
    450                 455                 460                 
Ile Arg Ala Leu Gly Arg Asn Lys Pro His Thr Pro Phe Arg Ala Ser
465                 470                 475                 480 
Lys Leu Thr Gln Val Leu Arg Asp Ser Phe Ile Gly Glu Asn Ser Arg
                485                 490                 495     
Thr Cys Met Ile Ala Thr Ile Ser Pro Gly Met Ala Ser Cys Glu Asn
            500                 505                 510         
Thr Leu Asn Thr Leu Arg Tyr Ala Asn Arg Val Lys Glu Leu Thr Val
        515                 520                 525             
Asp Pro Thr Ala Ala Gly Asp Val Arg Pro Ile Met His His Pro Pro
    530                 535                 540                 
Asn Gln Ile Asp Asp Leu Glu Thr Gln Trp Gly Val Gly Ser Ser Pro
545                 550                 555                 560 
Gln Arg Asp Asp Leu Lys Leu Leu Cys Glu Gln Asn Glu Glu Glu Val
                565                 570                 575     
Ser Pro Gln Leu Phe Thr Phe His Glu Ala Val Ser Gln Met Val Glu
            580                 585                 590         
Met Glu Glu Gln Val Val Glu Asp His Arg Ala Val Phe Gln Glu Ser
        595                 600                 605             
Ile Arg Trp Leu Glu Asp Glu Lys Ala Leu Leu Glu Met Thr Glu Glu
    610                 615                 620                 
Val Asp Tyr Asp Val Asp Ser Tyr Ala Thr Gln Leu Glu Ala Ile Leu
625                 630                 635                 640 
Glu Gln Lys Ile Asp Ile Leu Thr Glu Leu Arg Asp Lys Val Lys Ser
                645                 650                 655     
Phe Arg Ala Ala Leu Gln Glu Glu Glu Gln Ala Ser Lys Gln Ile Asn
            660                 665                 670         
Pro Lys Arg Pro Arg Ala Leu
        675                 


<210> 1967
<211> 2092
<212> PRT
<213> Homo sapiens

<400> 1967
Met Ala His Leu Gly Asn Tyr Asp Ser Gly Thr Ala Glu Thr Pro Glu
 1               5                  10                  15      
Thr Asp Glu Ser Val Ser Ser Ser Asn Ala Ser Leu Lys Leu Arg Arg
            20                  25                  30          
Lys Pro Arg Glu Ser Asp Phe Glu Thr Ile Lys Leu Ile Ser Asn Gly
        35                  40                  45              
Ala Tyr Gly Ala Val Tyr Phe Val Arg His Lys Glu Ser Arg Gln Arg
    50                  55                  60                  
Phe Ala Met Lys Lys Ile Asn Lys Gln Asn Leu Ile Leu Arg Asn Gln
65                  70                  75                  80  
Ile Gln Gln Ala Phe Val Glu Arg Asp Ile Leu Thr Phe Ala Glu Asn
                85                  90                  95      
Pro Phe Val Val Ser Met Tyr Cys Ser Phe Glu Thr Arg Arg His Leu
            100                 105                 110         
Cys Met Val Met Glu Tyr Val Glu Gly Gly Asp Cys Ala Thr Leu Met
        115                 120                 125             
Lys Asn Met Gly Pro Leu Pro Val Asp Met Ala Arg Met Tyr Phe Ala
    130                 135                 140                 
Glu Thr Val Leu Ala Leu Glu Tyr Leu His Asn Tyr Gly Ile Val His
145                 150                 155                 160 
Arg Asp Leu Lys Pro Asp Asn Leu Leu Val Thr Ser Met Gly His Ile
                165                 170                 175     
Lys Leu Thr Asp Phe Gly Leu Ser Lys Val Gly Leu Met Ser Met Thr
            180                 185                 190         
Thr Asn Leu Tyr Glu Gly His Ile Glu Lys Asp Ala Arg Glu Phe Leu
        195                 200                 205             
Asp Lys Gln Val Cys Gly Thr Pro Glu Tyr Ile Ala Pro Glu Val Ile
    210                 215                 220                 
Leu Arg Gln Gly Tyr Gly Lys Pro Val Asp Trp Trp Ala Met Gly Ile
225                 230                 235                 240 
Ile Leu Tyr Glu Phe Leu Val Gly Cys Val Pro Phe Phe Gly Asp Thr
                245                 250                 255     
Pro Glu Glu Leu Phe Gly Gln Val Ile Ser Asp Glu Ile Asn Trp Pro
            260                 265                 270         
Glu Lys Asp Glu Ala Pro Pro Pro Asp Ala Gln Asp Leu Ile Thr Leu
        275                 280                 285             
Leu Leu Arg Gln Asn Pro Leu Glu Arg Leu Gly Thr Gly Gly Ala Tyr
    290                 295                 300                 
Glu Val Lys Gln His Arg Phe Phe Arg Ser Leu Asp Trp Asn Ser Leu
305                 310                 315                 320 
Leu Arg Gln Lys Ala Glu Phe Ile Pro Gln Leu Glu Ser Glu Asp Asp
                325                 330                 335     
Thr Ser Tyr Phe Asp Thr Arg Ser Glu Lys Tyr His His Met Glu Thr
            340                 345                 350         
Glu Glu Glu Asp Asp Thr Asn Asp Glu Asp Phe Asn Val Glu Ile Arg
        355                 360                 365             
Gln Phe Ser Ser Cys Ser His Arg Phe Ser Lys Val Phe Ser Ser Ile
    370                 375                 380                 
Asp Arg Ile Thr Gln Asn Ser Ala Glu Glu Lys Glu Asp Ser Val Asp
385                 390                 395                 400 
Lys Thr Lys Ser Thr Thr Leu Pro Ser Thr Glu Thr Leu Ser Trp Ser
                405                 410                 415     
Ser Glu Tyr Ser Glu Met Gln Gln Leu Ser Thr Ser Asn Ser Ser Asp
            420                 425                 430         
Thr Glu Ser Asn Arg His Lys Leu Ser Ser Gly Leu Leu Pro Lys Leu
        435                 440                 445             
Ala Ile Ser Thr Glu Gly Glu Gln Asp Glu Ala Ala Ser Cys Pro Gly
    450                 455                 460                 
Asp Pro His Glu Glu Pro Gly Lys Pro Ala Leu Pro Pro Glu Glu Cys
465                 470                 475                 480 
Ala Gln Glu Glu Pro Glu Val Thr Thr Pro Ala Ser Thr Ile Ser Ser
                485                 490                 495     
Ser Thr Leu Ser Val Gly Ser Phe Ser Glu His Leu Asp Gln Ile Asn
            500                 505                 510         
Gly Arg Ser Glu Cys Val Asp Ser Thr Asp Asn Ser Ser Lys Pro Ser
        515                 520                 525             
Ser Glu Pro Ala Ser His Met Ala Arg Gln Arg Leu Glu Ser Thr Glu
    530                 535                 540                 
Lys Lys Lys Ile Ser Gly Lys Val Thr Lys Ser Leu Ser Ala Ser Ala
545                 550                 555                 560 
Leu Ser Leu Met Ile Pro Gly Asp Met Phe Ala Val Ser Pro Leu Gly
                565                 570                 575     
Ser Pro Met Ser Pro His Ser Leu Ser Ser Asp Pro Ser Ser Ser Arg
            580                 585                 590         
Asp Ser Ser Pro Ser Arg Asp Ser Ser Ala Ala Ser Ala Ser Pro His
        595                 600                 605             
Gln Pro Ile Val Ile His Ser Ser Gly Lys Asn Tyr Gly Phe Thr Ile
    610                 615                 620                 
Arg Ala Ile Arg Val Tyr Val Gly Asp Ser Asp Ile Tyr Thr Val His
625                 630                 635                 640 
His Ile Val Trp Asn Val Glu Glu Gly Ser Pro Ala Cys Gln Ala Gly
                645                 650                 655     
Leu Lys Ala Gly Asp Leu Ile Thr His Ile Asn Gly Glu Pro Val His
            660                 665                 670         
Gly Leu Val His Thr Glu Val Ile Glu Leu Leu Leu Lys Ser Gly Asn
        675                 680                 685             
Lys Val Ser Ile Thr Thr Thr Pro Phe Glu Asn Thr Ser Ile Lys Thr
    690                 695                 700                 
Gly Pro Ala Arg Arg Asn Ser Tyr Lys Ser Arg Met Val Arg Arg Ser
705                 710                 715                 720 
Lys Lys Ser Lys Lys Lys Glu Ser Leu Glu Arg Arg Arg Ser Leu Phe
                725                 730                 735     
Lys Lys Leu Ala Lys Gln Pro Ser Pro Leu Leu His Thr Ser Arg Ser
            740                 745                 750         
Phe Ser Cys Leu Asn Arg Ser Leu Ser Ser Gly Glu Ser Leu Pro Gly
        755                 760                 765             
Ser Pro Thr His Ser Leu Ser Pro Arg Ser Pro Thr Pro Ser Tyr Arg
    770                 775                 780                 
Ser Thr Pro Asp Phe Pro Ser Gly Thr Asn Ser Ser Gln Ser Ser Ser
785                 790                 795                 800 
Pro Ser Ser Ser Ala Pro Asn Ser Pro Ala Gly Ser Gly His Ile Arg
                805                 810                 815     
Pro Ser Thr Leu His Gly Leu Ala Pro Lys Leu Gly Gly Gln Arg Tyr
            820                 825                 830         
Arg Ser Gly Arg Arg Lys Ser Ala Gly Asn Ile Pro Leu Ser Pro Leu
        835                 840                 845             
Ala Arg Thr Pro Ser Pro Thr Pro Gln Pro Thr Ser Pro Gln Arg Ser
    850                 855                 860                 
Pro Ser Pro Leu Leu Gly His Ser Leu Gly Asn Ser Lys Ile Ala Gln
865                 870                 875                 880 
Ala Phe Pro Ser Lys Met His Ser Pro Pro Thr Ile Val Arg His Ile
                885                 890                 895     
Val Arg Pro Lys Ser Ala Glu Pro Pro Arg Ser Pro Leu Leu Lys Arg
            900                 905                 910         
Val Gln Ser Glu Glu Lys Leu Ser Pro Ser Tyr Gly Ser Asp Lys Lys
        915                 920                 925             
His Leu Cys Ser Arg Lys His Ser Leu Glu Val Thr Gln Glu Glu Val
    930                 935                 940                 
Gln Arg Glu Gln Ser Gln Arg Glu Ala Pro Leu Gln Ser Leu Asp Glu
945                 950                 955                 960 
Asn Val Cys Asp Val Pro Pro Leu Ser Arg Ala Arg Pro Val Glu Gln
                965                 970                 975     
Gly Cys Leu Lys Arg Pro Val Ser Arg Lys Val Gly Arg Gln Glu Ser
            980                 985                 990         
Val Asp Asp Leu Asp Arg Asp Lys Leu Lys Ala Lys Val Val Val Lys
        995                 1000                1005            
Lys Ala Asp Gly Phe Pro Glu Lys Gln Glu Ser His Gln Lys Ser His
    1010                1015                1020                
Gly Pro Gly Ser Asp Leu Glu Asn Phe Ala Leu Phe Lys Leu Glu Glu
1025                1030                1035                1040
Arg Glu Lys Lys Val Tyr Pro Lys Ala Val Glu Arg Ser Ser Thr Phe
                1045                1050                1055    
Glu Asn Lys Ala Ser Met Gln Glu Ala Pro Pro Leu Gly Ser Leu Leu
            1060                1065                1070        
Lys Asp Ala Leu His Lys Gln Ala Ser Val Arg Ala Ser Glu Gly Ala
        1075                1080                1085            
Met Ser Asp Gly Pro Val Pro Ala Glu His Arg Gln Gly Gly Gly Asp
    1090                1095                1100                
Phe Arg Arg Ala Pro Ala Pro Gly Thr Leu Gln Asp Gly Leu Cys His
1105                1110                1115                1120
Ser Leu Asp Arg Gly Ile Ser Gly Lys Gly Glu Gly Thr Glu Lys Ser
                1125                1130                1135    
Ser Gln Ala Lys Glu Leu Leu Arg Cys Glu Lys Leu Asp Ser Lys Leu
            1140                1145                1150        
Ala Asn Ile Asp Tyr Leu Arg Lys Lys Met Ser Leu Glu Asp Lys Glu
        1155                1160                1165            
Asp Asn Leu Cys Pro Val Leu Lys Pro Lys Met Thr Ala Gly Ser His
    1170                1175                1180                
Glu Cys Leu Pro Gly Asn Pro Val Arg Pro Thr Gly Gly Gln Gln Glu
1185                1190                1195                1200
Pro Pro Pro Ala Ser Glu Ser Arg Ala Phe Val Ser Ser Thr His Ala
                1205                1210                1215    
Ala Gln Met Ser Ala Val Ser Phe Val Pro Leu Lys Ala Leu Thr Gly
            1220                1225                1230        
Arg Val Asp Ser Gly Thr Glu Lys Pro Gly Leu Val Ala Pro Glu Ser
        1235                1240                1245            
Pro Val Arg Lys Ser Pro Ser Glu Tyr Lys Leu Glu Gly Arg Ser Val
    1250                1255                1260                
Ser Cys Leu Lys Pro Ile Glu Gly Thr Leu Asp Ile Ala Leu Leu Ser
1265                1270                1275                1280
Gly Pro Gln Ala Ser Lys Thr Glu Leu Pro Ser Pro Glu Ser Ala Gln
                1285                1290                1295    
Ser Pro Ser Pro Ser Gly Asp Val Arg Ala Ser Val Pro Pro Val Leu
            1300                1305                1310        
Pro Ser Ser Ser Gly Lys Lys Asn Asp Thr Thr Ser Ala Arg Glu Leu
        1315                1320                1325            
Ser Pro Ser Ser Leu Lys Met Asn Lys Ser Tyr Leu Leu Glu Pro Trp
    1330                1335                1340                
Phe Leu Pro Pro Ser Arg Gly Leu Gln Asn Ser Pro Ala Val Ser Leu
1345                1350                1355                1360
Pro Asp Pro Glu Phe Lys Arg Asp Arg Lys Gly Pro His Pro Thr Ala
                1365                1370                1375    
Arg Ser Pro Gly Thr Val Met Glu Ser Asn Pro Gln Gln Arg Glu Gly
            1380                1385                1390        
Ser Ser Pro Lys His Gln Asp His Thr Thr Asp Pro Lys Leu Leu Thr
        1395                1400                1405            
Cys Leu Gly Gln Asn Leu His Ser Pro Asp Leu Ala Arg Pro Arg Cys
    1410                1415                1420                
Pro Leu Pro Pro Glu Ala Ser Pro Ser Arg Glu Lys Pro Gly Leu Arg
1425                1430                1435                1440
Glu Ser Ser Glu Arg Gly Pro Pro Thr Ala Arg Ser Glu Arg Ser Ala
                1445                1450                1455    
Ala Arg Ala Asp Thr Cys Arg Glu Pro Ser Met Glu Leu Cys Phe Pro
            1460                1465                1470        
Glu Thr Ala Lys Thr Ser Asp Asn Ser Lys Asn Leu Leu Ser Val Gly
        1475                1480                1485            
Arg Thr His Pro Asp Phe Tyr Thr Gln Thr Gln Ala Met Glu Lys Ala
    1490                1495                1500                
Trp Ala Pro Gly Gly Lys Thr Asn His Lys Asp Gly Pro Gly Glu Ala
1505                1510                1515                1520
Arg Pro Pro Pro Arg Asp Asn Ser Ser Leu His Ser Ala Gly Ile Pro
                1525                1530                1535    
Cys Glu Lys Glu Leu Gly Lys Val Arg Arg Gly Val Glu Pro Lys Pro
            1540                1545                1550        
Glu Ala Leu Leu Ala Arg Arg Ser Leu Gln Pro Pro Gly Ile Glu Ser
        1555                1560                1565            
Glu Lys Ser Glu Lys Leu Ser Ser Phe Pro Ser Leu Gln Lys Asp Gly
    1570                1575                1580                
Ala Lys Glu Pro Glu Arg Lys Glu Gln Pro Leu Gln Arg His Pro Ser
1585                1590                1595                1600
Ser Ile Pro Pro Pro Pro Leu Thr Ala Lys Asp Leu Ser Ser Pro Ala
                1605                1610                1615    
Ala Arg Gln His Cys Ser Ser Pro Ser His Ala Ser Gly Arg Glu Pro
            1620                1625                1630        
Gly Ala Lys Pro Ser Thr Ala Glu Pro Ser Ser Ser Pro Gln Asp Pro
        1635                1640                1645            
Pro Lys Pro Val Ala Ala His Ser Glu Ser Ser Ser His Lys Pro Arg
    1650                1655                1660                
Pro Gly Pro Asp Pro Gly Pro Pro Lys Thr Lys His Pro Asp Arg Ser
1665                1670                1675                1680
Leu Ser Ser Gln Lys Pro Ser Val Gly Ala Thr Lys Gly Lys Glu Pro
                1685                1690                1695    
Ala Thr Gln Ser Leu Gly Gly Ser Ser Arg Glu Gly Lys Gly His Ser
            1700                1705                1710        
Lys Ser Gly Pro Asp Val Phe Pro Ala Thr Pro Gly Ser Gln Asn Lys
        1715                1720                1725            
Ala Ser Asp Gly Ile Gly Gln Gly Glu Gly Gly Pro Ser Val Pro Leu
    1730                1735                1740                
His Thr Asp Arg Ala Pro Leu Asp Ala Lys Pro Gln Pro Thr Ser Gly
1745                1750                1755                1760
Gly Arg Pro Leu Glu Val Leu Glu Lys Pro Val His Leu Pro Arg Pro
                1765                1770                1775    
Gly His Pro Gly Pro Ser Glu Pro Ala Asp Gln Lys Leu Ser Ala Val
            1780                1785                1790        
Gly Glu Lys Gln Thr Leu Ser Pro Lys His Pro Lys Pro Ser Thr Val
        1795                1800                1805            
Lys Asp Cys Pro Thr Leu Cys Lys Gln Thr Asp Asn Arg Gln Thr Asp
    1810                1815                1820                
Lys Ser Pro Ser Gln Pro Ala Ala Asn Thr Asp Arg Arg Ala Glu Gly
1825                1830                1835                1840
Lys Lys Cys Thr Glu Ala Leu Tyr Ala Pro Ala Glu Gly Asp Lys Leu
                1845                1850                1855    
Glu Ala Gly Leu Ser Phe Val His Ser Glu Asn Arg Leu Lys Gly Ala
            1860                1865                1870        
Glu Arg Pro Ala Ala Gly Val Gly Lys Gly Phe Pro Glu Ala Arg Gly
        1875                1880                1885            
Lys Gly Pro Gly Pro Gln Lys Pro Pro Thr Glu Ala Asp Lys Pro Asn
    1890                1895                1900                
Gly Met Lys Arg Ser Pro Ser Ala Thr Gly Gln Ser Ser Phe Arg Ser
1905                1910                1915                1920
Thr Ala Leu Pro Glu Lys Ser Leu Ser Cys Ser Ser Ser Phe Pro Glu
                1925                1930                1935    
Thr Arg Ala Gly Val Arg Glu Ala Ser Ala Ala Ser Ser Asp Thr Ser
            1940                1945                1950        
Ser Ala Lys Ala Ala Gly Gly Met Leu Glu Leu Pro Ala Pro Ser Asn
        1955                1960                1965            
Arg Asp His Arg Lys Ala Gln Pro Ala Gly Glu Gly Arg Thr His Met
    1970                1975                1980                
Thr Lys Ser Asp Ser Leu Pro Ser Phe Arg Val Ser Thr Leu Pro Leu
1985                1990                1995                2000
Glu Ser His His Pro Asp Pro Asn Thr Met Gly Gly Ala Ser His Arg
                2005                2010                2015    
Asp Arg Ala Leu Ser Val Thr Ala Thr Val Gly Glu Thr Lys Gly Lys
            2020                2025                2030        
Asp Pro Ala Pro Ala Gln Pro Pro Pro Ala Arg Lys Gln Asn Val Gly
        2035                2040                2045            
Arg Asp Val Thr Lys Pro Ser Pro Ala Pro Asn Thr Asp Arg Pro Ile
    2050                2055                2060                
Ser Leu Ser Asn Glu Lys Asp Phe Val Val Arg Gln Arg Arg Gly Lys
2065                2070                2075                2080
Glu Ser Leu Arg Ser Ser Pro His Lys Lys Ala Leu
                2085                2090        


<210> 1968
<211> 1748
<212> PRT
<213> Homo sapiens

<400> 1968
Met Ala Arg Phe Gly Glu Ala Val Val Ala Arg Pro Gly Ser Gly Asp
 1               5                  10                  15      
Gly Asp Ser Asp Gln Ser Arg Asn Arg Gln Gly Thr Pro Val Pro Ala
            20                  25                  30          
Ser Gly Gln Ala Ala Ala Tyr Lys Gln Thr Lys Ala Gln Arg Ala Arg
        35                  40                  45              
Thr Met Ala Leu Tyr Asn Pro Ile Pro Val Arg Gln Asn Cys Phe Thr
    50                  55                  60                  
Val Asn Arg Ser Leu Phe Ile Phe Gly Glu Asp Asn Ile Val Arg Lys
65                  70                  75                  80  
Tyr Ala Lys Lys Leu Ile Asp Trp Pro Pro Phe Glu Tyr Met Ile Leu
                85                  90                  95      
Ala Thr Ile Ile Ala Asn Cys Ile Val Leu Ala Leu Glu Gln His Leu
            100                 105                 110         
Pro Glu Asp Asp Lys Thr Pro Met Ser Arg Arg Leu Glu Lys Thr Glu
        115                 120                 125             
Pro Tyr Phe Ile Gly Ile Phe Cys Phe Glu Ala Gly Ile Lys Ile Val
    130                 135                 140                 
Ala Leu Gly Phe Ile Phe His Lys Gly Ser Tyr Leu Arg Asn Gly Trp
145                 150                 155                 160 
Asn Val Met Asp Phe Ile Val Val Leu Ser Gly Ile Leu Ala Thr Ala
                165                 170                 175     
Gly Thr His Phe Asn Thr His Val Asp Leu Arg Thr Leu Arg Ala Val
            180                 185                 190         
Arg Val Leu Arg Pro Leu Lys Leu Val Ser Gly Ile Pro Ser Leu Gln
        195                 200                 205             
Ile Val Leu Lys Ser Ile Met Lys Ala Met Val Pro Leu Leu Gln Ile
    210                 215                 220                 
Gly Leu Leu Leu Phe Phe Ala Ile Leu Met Phe Ala Ile Ile Gly Leu
225                 230                 235                 240 
Glu Phe Tyr Ser Gly Lys Leu His Arg Ala Cys Phe Met Asn Asn Ser
                245                 250                 255     
Gly Ile Leu Glu Gly Phe Asp Pro Pro His Pro Cys Gly Val Gln Gly
            260                 265                 270         
Cys Pro Ala Gly Tyr Glu Cys Lys Asp Trp Ile Gly Pro Asn Asp Gly
        275                 280                 285             
Ile Thr Gln Phe Asp Asn Ile Leu Phe Ala Val Leu Thr Val Phe Gln
    290                 295                 300                 
Cys Ile Thr Met Glu Gly Trp Thr Thr Val Leu Tyr Asn Thr Asn Asp
305                 310                 315                 320 
Ala Leu Gly Ala Thr Trp Asn Trp Leu Tyr Phe Ile Pro Leu Ile Ile
                325                 330                 335     
Ile Gly Ser Phe Phe Val Leu Asn Leu Val Leu Gly Val Leu Ser Gly
            340                 345                 350         
Glu Phe Ala Lys Glu Arg Glu Arg Val Glu Asn Arg Arg Ala Phe Met
        355                 360                 365             
Lys Leu Arg Arg Gln Gln Gln Ile Glu Arg Glu Leu Asn Gly Tyr Arg
    370                 375                 380                 
Ala Trp Ile Asp Lys Ala Glu Glu Val Met Leu Ala Glu Glu Asn Lys
385                 390                 395                 400 
Asn Ala Gly Thr Ser Ala Leu Glu Val Leu Arg Arg Ala Thr Ile Lys
                405                 410                 415     
Arg Ser Arg Thr Glu Ala Met Thr Arg Asp Ser Ser Asp Glu His Cys
            420                 425                 430         
Val Asp Ile Ser Ser Val Gly Thr Pro Leu Ala Arg Ala Ser Ile Lys
        435                 440                 445             
Ser Ala Lys Val Asp Gly Val Ser Tyr Phe Arg His Lys Glu Arg Leu
    450                 455                 460                 
Leu Arg Ile Ser Ile Arg His Met Val Lys Ser Gln Val Phe Tyr Trp
465                 470                 475                 480 
Ile Val Leu Ser Leu Val Ala Leu Asn Thr Ala Cys Val Ala Ile Val
                485                 490                 495     
His His Asn Gln Pro Gln Trp Leu Thr His Leu Leu Tyr Tyr Ala Glu
            500                 505                 510         
Phe Leu Phe Leu Gly Leu Phe Leu Leu Glu Met Ser Leu Lys Met Tyr
        515                 520                 525             
Gly Met Gly Pro Arg Leu Tyr Phe His Ser Ser Phe Asn Cys Phe Asp
    530                 535                 540                 
Phe Gly Val Thr Val Gly Ser Ile Phe Glu Val Val Trp Ala Ile Phe
545                 550                 555                 560 
Arg Pro Gly Thr Ser Phe Gly Ile Ser Val Leu Arg Ala Leu Arg Leu
                565                 570                 575     
Leu Arg Ile Phe Lys Ile Thr Lys Tyr Trp Ala Ser Leu Arg Asn Leu
            580                 585                 590         
Val Val Ser Leu Met Ser Ser Met Lys Ser Ile Ile Ser Leu Leu Phe
        595                 600                 605             
Leu Leu Phe Leu Phe Ile Val Val Phe Ala Leu Leu Gly Met Gln Leu
    610                 615                 620                 
Phe Gly Gly Arg Phe Asn Phe Asn Asp Gly Thr Pro Ser Ala Asn Phe
625                 630                 635                 640 
Asp Thr Phe Pro Ala Ala Ile Met Thr Val Phe Gln Ile Leu Thr Gly
                645                 650                 655     
Glu Asp Trp Asn Glu Val Met Tyr Asn Gly Ile Arg Ser Gln Gly Gly
            660                 665                 670         
Val Ser Ser Gly Met Trp Ser Ala Ile Tyr Phe Ile Val Leu Thr Leu
        675                 680                 685             
Phe Gly Asn Tyr Thr Leu Leu Asn Val Phe Leu Ala Ile Ala Val Asp
    690                 695                 700                 
Asn Leu Ala Asn Ala Gln Glu Leu Thr Lys Asp Glu Gln Glu Glu Glu
705                 710                 715                 720 
Glu Ala Phe Asn Gln Lys His Ala Leu Gln Lys Ala Lys Glu Val Ser
                725                 730                 735     
Pro Met Ser Ala Pro Asn Met Pro Ser Ile Glu Arg Glu Arg Arg Arg
            740                 745                 750         
Arg His His Met Ser Val Trp Glu Gln Arg Thr Ser Gln Leu Arg Lys
        755                 760                 765             
His Met Gln Met Ser Ser Gln Glu Ala Leu Asn Arg Glu Glu Ala Pro
    770                 775                 780                 
Thr Met Asn Pro Leu Asn Pro Leu Asn Pro Leu Ser Ser Leu Asn Pro
785                 790                 795                 800 
Leu Asn Ala His Pro Ser Leu Tyr Arg Arg Pro Arg Ala Ile Glu Gly
                805                 810                 815     
Leu Ala Leu Gly Leu Ala Leu Glu Lys Phe Glu Glu Glu Arg Ile Ser
            820                 825                 830         
Arg Gly Gly Ser Leu Lys Gly Asp Gly Gly Asp Arg Ser Ser Ala Leu
        835                 840                 845             
Asp Asn Gln Arg Thr Pro Leu Ser Leu Gly Gln Arg Glu Pro Pro Trp
    850                 855                 860                 
Leu Ala Arg Pro Cys His Gly Asn Cys Asp Pro Thr Gln Gln Glu Ala
865                 870                 875                 880 
Gly Gly Gly Glu Ala Val Val Thr Phe Glu Asp Arg Ala Arg His Arg
                885                 890                 895     
Gln Ser Gln Arg Arg Ser Arg His Arg Arg Val Arg Thr Glu Gly Lys
            900                 905                 910         
Glu Ser Ser Ser Ala Ser Arg Ser Arg Ser Ala Ser Gln Glu Arg Ser
        915                 920                 925             
Leu Asp Glu Ala Met Pro Thr Glu Gly Glu Lys Asp His Glu Leu Arg
    930                 935                 940                 
Gly Asn His Gly Ala Lys Glu Pro Thr Ile Gln Glu Glu Arg Ala Gln
945                 950                 955                 960 
Asp Leu Arg Arg Thr Asn Ser Leu Met Val Ser Arg Gly Ser Gly Leu
                965                 970                 975     
Ala Gly Gly Leu Asp Glu Ala Asp Thr Pro Leu Val Leu Pro His Pro
            980                 985                 990         
Glu Leu Glu Val Gly Lys His Val Val Leu Thr Glu Gln Glu Pro Glu
        995                 1000                1005            
Gly Ser Ser Glu Gln Ala Leu Leu Gly Asn Val Gln Leu Asp Met Gly
    1010                1015                1020                
Arg Val Ile Ser Gln Ser Glu Pro Asp Leu Ser Cys Ile Thr Ala Asn
1025                1030                1035                1040
Thr Asp Lys Ala Thr Thr Glu Ser Thr Ser Val Thr Val Ala Ile Pro
                1045                1050                1055    
Asp Val Asp Pro Leu Val Asp Ser Thr Val Val His Ile Ser Asn Lys
            1060                1065                1070        
Thr Asp Gly Glu Ala Ser Pro Leu Lys Glu Ala Glu Ile Arg Glu Asp
        1075                1080                1085            
Glu Glu Glu Val Glu Lys Lys Lys Gln Lys Lys Glu Lys Arg Glu Thr
    1090                1095                1100                
Gly Lys Ala Met Val Pro His Ser Ser Met Phe Ile Phe Ser Thr Thr
1105                1110                1115                1120
Asn Pro Ile Arg Arg Ala Cys His Tyr Ile Val Asn Leu Arg Tyr Phe
                1125                1130                1135    
Glu Met Cys Ile Leu Leu Val Ile Ala Ala Ser Ser Ile Ala Leu Ala
            1140                1145                1150        
Ala Glu Asp Pro Val Leu Thr Asn Ser Glu Arg Asn Lys Val Leu Arg
        1155                1160                1165            
Tyr Phe Asp Tyr Val Phe Thr Gly Val Phe Thr Phe Glu Met Val Ile
    1170                1175                1180                
Lys Met Ile Asp Gln Gly Leu Ile Leu Gln Asp Gly Ser Tyr Phe Arg
1185                1190                1195                1200
Asp Leu Trp Asn Ile Leu Asp Phe Val Val Val Val Gly Ala Leu Val
                1205                1210                1215    
Ala Phe Ala Leu Ala Asn Ala Leu Gly Thr Asn Lys Gly Arg Asp Ile
            1220                1225                1230        
Lys Thr Ile Lys Ser Leu Arg Val Leu Arg Val Leu Arg Pro Leu Lys
        1235                1240                1245            
Thr Ile Lys Arg Leu Pro Lys Leu Lys Ala Val Phe Asp Cys Val Val
    1250                1255                1260                
Thr Ser Leu Lys Asn Val Phe Asn Ile Leu Ile Val Tyr Lys Leu Phe
1265                1270                1275                1280
Met Phe Ile Phe Ala Val Ile Ala Val Gln Leu Phe Lys Gly Lys Phe
                1285                1290                1295    
Phe Tyr Cys Thr Asp Ser Ser Lys Asp Thr Glu Lys Glu Cys Ile Gly
            1300                1305                1310        
Asn Tyr Val Asp His Glu Lys Asn Lys Met Glu Val Lys Gly Arg Glu
        1315                1320                1325            
Trp Lys Arg His Glu Phe His Tyr Asp Asn Ile Ile Trp Ala Leu Leu
    1330                1335                1340                
Thr Leu Phe Thr Val Ser Thr Gly Glu Gly Trp Pro Gln Val Leu Gln
1345                1350                1355                1360
His Ser Val Asp Val Thr Glu Glu Asp Arg Gly Pro Ser Arg Ser Asn
                1365                1370                1375    
Arg Met Glu Met Ser Ile Phe Tyr Val Val Tyr Phe Val Val Phe Pro
            1380                1385                1390        
Phe Phe Phe Val Asn Ile Phe Val Ala Leu Ile Ile Ile Thr Phe Gln
        1395                1400                1405            
Glu Gln Gly Asp Lys Met Met Glu Glu Cys Ser Leu Glu Lys Asn Glu
    1410                1415                1420                
Arg Ala Cys Ile Asp Phe Ala Ile Ser Ala Lys Pro Leu Thr Arg Tyr
1425                1430                1435                1440
Met Pro Gln Asn Arg His Thr Phe Gln Tyr Arg Val Trp His Phe Val
                1445                1450                1455    
Val Ser Pro Ser Phe Glu Tyr Thr Ile Met Ala Met Ile Ala Leu Asn
            1460                1465                1470        
Thr Val Val Leu Met Met Lys Tyr Tyr Ser Ala Pro Cys Thr Tyr Glu
        1475                1480                1485            
Leu Ala Leu Lys Tyr Leu Asn Ile Ala Phe Thr Met Val Phe Ser Leu
    1490                1495                1500                
Glu Cys Val Leu Lys Val Ile Ala Phe Gly Phe Leu Asn Tyr Phe Arg
1505                1510                1515                1520
Asp Thr Trp Asn Ile Phe Asp Phe Ile Thr Val Ile Gly Ser Ile Thr
                1525                1530                1535    
Glu Ile Ile Leu Thr Asp Ser Lys Leu Val Asn Thr Ser Gly Phe Asn
            1540                1545                1550        
Met Ser Phe Leu Lys Leu Phe Arg Ala Ala Arg Leu Ile Lys Leu Leu
        1555                1560                1565            
Arg Gln Gly Tyr Thr Ile Arg Ile Leu Leu Trp Thr Phe Val Gln Ser
    1570                1575                1580                
Phe Lys Ala Leu Pro Tyr Val Cys Leu Leu Ile Ala Met Leu Phe Phe
1585                1590                1595                1600
Ile Tyr Ala Ile Ile Gly Met Gln Val Phe Gly Asn Ile Lys Leu Asp
                1605                1610                1615    
Glu Glu Ser His Ile Asn Arg His Asn Asn Phe Arg Ser Phe Phe Gly
            1620                1625                1630        
Ser Leu Met Leu Leu Phe Arg Ser Ala Thr Gly Glu Ala Trp Gln Glu
        1635                1640                1645            
Ile Met Leu Ser Cys Leu Gly Glu Lys Gly Cys Glu Pro Asp Thr Thr
    1650                1655                1660                
Ala Pro Ser Gly Gln Asn Glu Asn Glu Arg Cys Gly Thr Asp Leu Ala
1665                1670                1675                1680
Tyr Val Tyr Phe Val Ser Phe Ile Phe Phe Cys Ser Phe Leu Met Leu
                1685                1690                1695    
Asn Leu Phe Val Ala Val Ile Met Asp Asn Phe Glu Tyr Leu Thr Arg
            1700                1705                1710        
Asp Ser Ser Ile Leu Gly Pro His His Leu Asp Glu Phe Val Arg Val
        1715                1720                1725            
Trp Ala Glu Tyr Asp Arg Ala Ala Val Ala Ala Ser Ile Thr Leu Arg
    1730                1735                1740                
Cys Met Lys Cys
1745            


<210> 1969
<211> 1088
<212> PRT
<213> Homo sapiens

<400> 1969
Met Leu Gln Thr Phe Asp Tyr Ser Arg Asp Pro Gln Glu Arg Glu Phe
 1               5                  10                  15      
Thr Thr Ala Val Ser Ser Pro Gly Gly Gln Ser Val Val Leu Gly Ser
            20                  25                  30          
Tyr Asp Arg Leu Arg Val Phe Asn Trp Ile Pro Arg Arg Ser Ile Trp
        35                  40                  45              
Glu Glu Ala Lys Pro Lys Glu Ile Thr Asn Leu Tyr Thr Ile Thr Ala
    50                  55                  60                  
Leu Ala Trp Lys Arg Asp Gly Ser Arg Leu Cys Val Gly Thr Leu Cys
65                  70                  75                  80  
Gly Gly Val Glu Gln Phe Asp Cys Cys Leu Arg Arg Ser Ile Tyr Lys
                85                  90                  95      
Asn Lys Phe Glu Leu Thr Tyr Val Gly Pro Ser Gln Val Ile Val Lys
            100                 105                 110         
Asn Leu Ser Ser Gly Thr Arg Val Val Leu Lys Ser His Tyr Gly Tyr
        115                 120                 125             
Glu Val Glu Glu Val Lys Ile Leu Gly Lys Glu Arg Tyr Leu Val Ala
    130                 135                 140                 
His Thr Ser Glu Thr Leu Leu Leu Gly Asp Leu Asn Thr Asn Arg Leu
145                 150                 155                 160 
Ser Glu Ile Ala Trp Gln Gly Ser Gly Gly Asn Glu Lys Tyr Phe Phe
                165                 170                 175     
Glu Asn Glu Asn Val Cys Met Ile Phe Asn Ala Gly Glu Leu Thr Leu
            180                 185                 190         
Val Glu Tyr Gly Asn Asn Asp Thr Leu Gly Ser Val Arg Thr Glu Phe
        195                 200                 205             
Met Asn Pro His Leu Ile Ser Val Arg Ile Asn Glu Arg Cys Gln Arg
    210                 215                 220                 
Gly Thr Glu Asp Asn Lys Lys Leu Ala Tyr Leu Ile Asp Ile Lys Thr
225                 230                 235                 240 
Ile Ala Ile Val Asp Leu Ile Gly Gly Tyr Asn Ile Gly Thr Val Ser
                245                 250                 255     
His Glu Ser Arg Val Asp Trp Leu Glu Leu Asn Glu Thr Gly His Lys
            260                 265                 270         
Leu Leu Phe Arg Asp Arg Lys Leu Arg Leu His Leu Tyr Asp Ile Glu
        275                 280                 285             
Ser Cys Ser Lys Thr Met Ile Leu Asn Phe Cys Ser Tyr Met Gln Trp
    290                 295                 300                 
Val Pro Gly Ser Asp Val Leu Val Ala Gln Asn Arg Asn Ser Leu Cys
305                 310                 315                 320 
Val Trp Tyr Asn Ile Glu Ala Pro Glu Arg Val Thr Met Phe Thr Ile
                325                 330                 335     
Arg Gly Asp Val Ile Gly Leu Glu Arg Gly Gly Gly Lys Thr Glu Val
            340                 345                 350         
Met Val Met Glu Gly Val Thr Thr Val Ala Tyr Thr Leu Asp Glu Gly
        355                 360                 365             
Leu Ile Glu Phe Gly Thr Ala Ile Asp Asp Gly Asn Tyr Ile Arg Ala
    370                 375                 380                 
Thr Ala Phe Leu Glu Thr Leu Glu Met Thr Pro Glu Thr Glu Ala Met
385                 390                 395                 400 
Trp Lys Thr Leu Ser Lys Leu Ala Leu Glu Ala Arg Gln Leu His Ile
                405                 410                 415     
Ala Glu Arg Cys Phe Ser Ala Leu Gly Gln Val Ala Lys Ala Arg Phe
            420                 425                 430         
Leu His Glu Thr Asn Glu Ile Ala Asp Gln Val Ser Arg Glu Tyr Gly
        435                 440                 445             
Gly Glu Gly Thr Asp Phe Tyr Gln Val Arg Ala Arg Leu Ala Met Leu
    450                 455                 460                 
Glu Lys Asn Tyr Lys Leu Ala Glu Met Ile Phe Leu Glu Gln Asn Ala
465                 470                 475                 480 
Val Glu Glu Ala Met Gly Met Tyr Gln Glu Leu His Arg Trp Asp Glu
                485                 490                 495     
Cys Ile Ala Val Ala Glu Ala Lys Gly His Pro Ala Leu Glu Lys Leu
            500                 505                 510         
Arg Arg Ser Tyr Tyr Gln Trp Leu Met Asp Thr Gln Gln Glu Glu Arg
        515                 520                 525             
Ala Gly Glu Leu Gln Glu Ser Gln Gly Asp Gly Leu Ala Ala Ile Ser
    530                 535                 540                 
Leu Tyr Leu Lys Ala Gly Leu Pro Ala Lys Ala Ala Arg Leu Val Leu
545                 550                 555                 560 
Thr Arg Glu Glu Leu Leu Ala Asn Thr Glu Leu Val Glu His Ile Thr
                565                 570                 575     
Ala Ala Leu Ile Lys Gly Glu Leu Tyr Glu Arg Ala Gly Asp Leu Phe
            580                 585                 590         
Glu Lys Ile His Asn Pro Gln Lys Ala Leu Glu Cys Tyr Arg Lys Gly
        595                 600                 605             
Asn Ala Phe Met Lys Ala Val Glu Leu Ala Arg Leu Ala Phe Pro Val
    610                 615                 620                 
Glu Val Val Lys Leu Glu Glu Ala Trp Gly Asp His Leu Val Gln Gln
625                 630                 635                 640 
Lys Gln Leu Asp Ala Ala Ile Asn His Tyr Ile Glu Ala Arg Cys Ser
                645                 650                 655     
Ile Lys Ala Ile Glu Ala Ala Leu Gly Ala Arg Gln Trp Lys Lys Ala
            660                 665                 670         
Ile Tyr Ile Leu Asp Leu Gln Asp Arg Asn Thr Ala Ser Lys Tyr Tyr
        675                 680                 685             
Pro Leu Val Ala Gln His Tyr Ala Ser Leu Gln Glu Tyr Glu Ile Ala
    690                 695                 700                 
Glu Glu Leu Tyr Thr Lys Gly Asp Arg Thr Lys Asp Ala Ile Asp Met
705                 710                 715                 720 
Tyr Thr Gln Ala Gly Arg Trp Glu Gln Ala His Lys Leu Ala Met Lys
                725                 730                 735     
Cys Met Arg Pro Glu Asp Val Ser Val Leu Tyr Ile Thr Gln Ala Gln
            740                 745                 750         
Glu Met Glu Lys Gln Gly Lys Tyr Arg Glu Ala Glu Arg Leu Tyr Val
        755                 760                 765             
Thr Val Gln Glu Pro Asp Leu Ala Ile Thr Met Tyr Lys Lys His Lys
    770                 775                 780                 
Leu Tyr Asp Asp Met Ile Arg Leu Val Gly Lys His His Pro Asp Leu
785                 790                 795                 800 
Leu Ser Asp Thr His Leu His Leu Gly Lys Glu Leu Glu Ala Glu Gly
                805                 810                 815     
Arg Leu Gln Glu Ala Glu Tyr His Tyr Leu Glu Ala Gln Glu Trp Lys
            820                 825                 830         
Ala Thr Val Asn Met Tyr Arg Ala Ser Gly Leu Trp Glu Glu Ala Tyr
        835                 840                 845             
Arg Trp Pro Glu Leu Lys Glu Gly Leu Met Pro Thr Asn Thr Trp Pro
    850                 855                 860                 
Ile Cys Gly Gln Arg Ala Trp Glu Glu Arg Leu Gln Leu Asp Cys Leu
865                 870                 875                 880 
Ile Ser Trp Asp Ser Trp Lys Leu Leu Leu Thr Thr Leu Gln Thr Ile
                885                 890                 895     
Ala Pro Leu Asn Leu Arg Leu Asn Ser Leu Gly Trp Pro Ser Ser Thr
            900                 905                 910         
Lys Pro Pro Arg Phe Ile Ser Asn Met Leu Cys Ser Trp Arg Met Arg
        915                 920                 925             
Val Asn Ser Lys Arg Leu Lys Leu Asn Ser Ser Glu Leu Val Asn Pro
    930                 935                 940                 
Arg Arg Gln Ser Ser Cys Leu Ser Ile Thr Arg Ile Gly Arg Gln Leu
945                 950                 955                 960 
Ser Val Trp Leu Arg Leu Thr Thr Leu Thr Val Ser Pro Arg Cys Leu
                965                 970                 975     
Trp Asp Arg Pro Gly Gly Pro Trp Arg Arg Arg Thr Phe Arg Lys Gln
            980                 985                 990         
Lys Gly Cys Cys Ser Gly Pro Arg Asp Gln Ala Trp Pro Ser Ile Ile
        995                 1000                1005            
Ile Arg Arg Leu Asp Tyr Gly Val Thr Leu Cys Ala Ser Ala Arg Thr
    1010                1015                1020                
Met Cys Pro Ala Ser Trp Arg Leu Cys Arg Lys Asn Met Ser Gly Lys
1025                1030                1035                1040
Leu Leu Arg Arg Gly Pro Gly Val Trp Arg Asp Leu Trp Asn Lys Leu
                1045                1050                1055    
Asp Thr Gly Ser Arg Leu Glu Ser Thr Ala Val Pro Trp Thr Ala Thr
            1060                1065                1070        
Ser Lys Cys Glu Thr Leu Glu Thr Ala Ala Trp Arg Arg Ser Ala Gly
        1075                1080                1085            


<210> 1970
<211> 2843
<212> PRT
<213> Homo sapiens

<400> 1970
Met Ala Ala Ala Ser Tyr Asp Gln Leu Leu Lys Gln Val Glu Ala Leu
 1               5                  10                  15      
Lys Met Glu Asn Ser Asn Leu Arg Gln Glu Leu Glu Asp Asn Ser Asn
            20                  25                  30          
His Leu Thr Lys Leu Glu Thr Glu Ala Ser Asn Met Lys Glu Val Leu
        35                  40                  45              
Lys Gln Leu Gln Gly Ser Ile Glu Asp Glu Ala Met Ala Ser Ser Gly
    50                  55                  60                  
Gln Ile Asp Leu Leu Glu Arg Leu Lys Glu Leu Asn Leu Asp Ser Ser
65                  70                  75                  80  
Asn Phe Pro Gly Val Lys Leu Arg Ser Lys Met Ser Leu Arg Ser Tyr
                85                  90                  95      
Gly Ser Arg Glu Gly Ser Val Ser Ser Arg Ser Gly Glu Cys Ser Pro
            100                 105                 110         
Val Pro Met Gly Ser Phe Pro Arg Arg Gly Phe Val Asn Gly Ser Arg
        115                 120                 125             
Glu Ser Thr Gly Tyr Leu Glu Glu Leu Glu Lys Glu Arg Ser Leu Leu
    130                 135                 140                 
Leu Ala Asp Leu Asp Lys Glu Glu Lys Glu Lys Asp Trp Tyr Tyr Ala
145                 150                 155                 160 
Gln Leu Gln Asn Leu Thr Lys Arg Ile Asp Ser Leu Pro Leu Thr Glu
                165                 170                 175     
Asn Phe Ser Leu Gln Thr Asp Met Thr Arg Arg Gln Leu Glu Tyr Glu
            180                 185                 190         
Ala Arg Gln Ile Arg Val Ala Met Glu Glu Gln Leu Gly Thr Cys Gln
        195                 200                 205             
Asp Met Glu Lys Arg Ala Gln Arg Arg Ile Ala Arg Ile Gln Gln Ile
    210                 215                 220                 
Glu Lys Asp Ile Leu Arg Ile Arg Gln Leu Leu Gln Ser Gln Ala Thr
225                 230                 235                 240 
Glu Ala Glu Arg Ser Ser Gln Asn Lys His Glu Thr Gly Ser His Asp
                245                 250                 255     
Ala Glu Arg Gln Asn Glu Gly Gln Gly Val Gly Glu Ile Asn Met Ala
            260                 265                 270         
Thr Ser Gly Asn Gly Gln Gly Ser Thr Thr Arg Met Asp His Glu Thr
        275                 280                 285             
Ala Ser Val Leu Ser Ser Ser Ser Thr His Ser Ala Pro Arg Arg Leu
    290                 295                 300                 
Thr Ser His Leu Gly Thr Lys Val Glu Met Val Tyr Ser Leu Leu Ser
305                 310                 315                 320 
Met Leu Gly Thr His Asp Lys Asp Asp Met Ser Arg Thr Leu Leu Ala
                325                 330                 335     
Met Ser Ser Ser Gln Asp Ser Cys Ile Ser Met Arg Gln Ser Gly Cys
            340                 345                 350         
Leu Pro Leu Leu Ile Gln Leu Leu His Gly Asn Asp Lys Asp Ser Val
        355                 360                 365             
Leu Leu Gly Asn Ser Arg Gly Ser Lys Glu Ala Arg Ala Arg Ala Ser
    370                 375                 380                 
Ala Ala Leu His Asn Ile Ile His Ser Gln Pro Asp Asp Lys Arg Gly
385                 390                 395                 400 
Arg Arg Glu Ile Arg Val Leu His Leu Leu Glu Gln Ile Arg Ala Tyr
                405                 410                 415     
Cys Glu Thr Cys Trp Glu Trp Gln Glu Ala His Glu Pro Gly Met Asp
            420                 425                 430         
Gln Asp Lys Asn Pro Met Pro Ala Pro Val Glu His Gln Ile Cys Pro
        435                 440                 445             
Ala Val Cys Val Leu Met Lys Leu Ser Phe Asp Glu Glu His Arg His
    450                 455                 460                 
Ala Met Asn Glu Leu Gly Gly Leu Gln Ala Ile Ala Glu Leu Leu Gln
465                 470                 475                 480 
Val Asp Cys Glu Met Tyr Gly Leu Thr Asn Asp His Tyr Ser Ile Thr
                485                 490                 495     
Leu Arg Arg Tyr Ala Gly Met Ala Leu Thr Asn Leu Thr Phe Gly Asp
            500                 505                 510         
Val Ala Asn Lys Ala Thr Leu Cys Ser Met Lys Gly Cys Met Arg Ala
        515                 520                 525             
Leu Val Ala Gln Leu Lys Ser Glu Ser Glu Asp Leu Gln Gln Val Ile
    530                 535                 540                 
Ala Ser Val Leu Arg Asn Leu Ser Trp Arg Ala Asp Val Asn Ser Lys
545                 550                 555                 560 
Lys Thr Leu Arg Glu Val Gly Ser Val Lys Ala Leu Met Glu Cys Ala
                565                 570                 575     
Leu Glu Val Lys Lys Glu Ser Thr Leu Lys Ser Val Leu Ser Ala Leu
            580                 585                 590         
Trp Asn Leu Ser Ala His Cys Thr Glu Asn Lys Ala Asp Ile Cys Ala
        595                 600                 605             
Val Asp Gly Ala Leu Ala Phe Leu Val Gly Thr Leu Thr Tyr Arg Ser
    610                 615                 620                 
Gln Thr Asn Thr Leu Ala Ile Ile Glu Ser Gly Gly Gly Ile Leu Arg
625                 630                 635                 640 
Asn Val Ser Ser Leu Ile Ala Thr Asn Glu Asp His Arg Gln Ile Leu
                645                 650                 655     
Arg Glu Asn Asn Cys Leu Gln Thr Leu Leu Gln His Leu Lys Ser His
            660                 665                 670         
Ser Leu Thr Ile Val Ser Asn Ala Cys Gly Thr Leu Trp Asn Leu Ser
        675                 680                 685             
Ala Arg Asn Pro Lys Asp Gln Glu Ala Leu Trp Asp Met Gly Ala Val
    690                 695                 700                 
Ser Met Leu Lys Asn Leu Ile His Ser Lys His Lys Met Ile Ala Met
705                 710                 715                 720 
Gly Ser Ala Ala Ala Leu Arg Asn Leu Met Ala Asn Arg Pro Ala Lys
                725                 730                 735     
Tyr Lys Asp Ala Asn Ile Met Ser Pro Gly Ser Ser Leu Pro Ser Leu
            740                 745                 750         
His Val Arg Lys Gln Lys Ala Leu Glu Ala Glu Leu Asp Ala Gln His
        755                 760                 765             
Leu Ser Glu Thr Phe Asp Asn Ile Asp Asn Leu Ser Pro Lys Ala Ser
    770                 775                 780                 
His Arg Ser Lys Gln Arg His Lys Gln Ser Leu Tyr Gly Asp Tyr Val
785                 790                 795                 800 
Phe Asp Thr Asn Arg His Asp Asp Asn Arg Ser Asp Asn Phe Asn Thr
                805                 810                 815     
Gly Asn Met Thr Val Leu Ser Pro Tyr Leu Asn Thr Thr Val Leu Pro
            820                 825                 830         
Ser Ser Ser Ser Ser Arg Gly Ser Leu Asp Ser Ser Arg Ser Glu Lys
        835                 840                 845             
Asp Arg Ser Leu Glu Arg Glu Arg Gly Ile Gly Leu Gly Asn Tyr His
    850                 855                 860                 
Pro Ala Thr Glu Asn Pro Gly Thr Ser Ser Lys Arg Gly Leu Gln Ile
865                 870                 875                 880 
Ser Thr Thr Ala Ala Gln Ile Ala Lys Val Met Glu Glu Val Ser Ala
                885                 890                 895     
Ile His Thr Ser Gln Glu Asp Arg Ser Ser Gly Ser Thr Thr Glu Leu
            900                 905                 910         
His Cys Val Thr Asp Glu Arg Asn Ala Leu Arg Arg Ser Ser Ala Ala
        915                 920                 925             
His Thr His Ser Asn Thr Tyr Asn Phe Thr Lys Ser Glu Asn Ser Asn
    930                 935                 940                 
Arg Thr Cys Ser Met Pro Tyr Ala Lys Leu Glu Tyr Lys Arg Ser Ser
945                 950                 955                 960 
Asn Asp Ser Leu Asn Ser Val Ser Ser Ser Asp Gly Tyr Gly Lys Arg
                965                 970                 975     
Gly Gln Met Lys Pro Ser Ile Glu Ser Tyr Ser Glu Asp Asp Glu Ser
            980                 985                 990         
Lys Phe Cys Ser Tyr Gly Gln Tyr Pro Ala Asp Leu Ala His Lys Ile
        995                 1000                1005            
His Ser Ala Asn His Met Asp Asp Asn Asp Gly Glu Leu Asp Thr Pro
    1010                1015                1020                
Ile Asn Tyr Ser Leu Lys Tyr Ser Asp Glu Gln Leu Asn Ser Gly Arg
1025                1030                1035                1040
Gln Ser Pro Ser Gln Asn Glu Arg Trp Ala Arg Pro Lys His Ile Ile
                1045                1050                1055    
Glu Asp Glu Ile Lys Gln Ser Glu Gln Arg Gln Ser Arg Asn Gln Ser
            1060                1065                1070        
Thr Thr Tyr Pro Val Tyr Thr Glu Ser Thr Asp Asp Lys His Leu Lys
        1075                1080                1085            
Phe Gln Pro His Phe Gly Gln Gln Glu Cys Val Ser Pro Tyr Arg Ser
    1090                1095                1100                
Arg Gly Ala Asn Gly Ser Glu Thr Asn Arg Val Gly Ser Asn His Gly
1105                1110                1115                1120
Ile Asn Gln Asn Val Ser Gln Ser Leu Cys Gln Glu Asp Asp Tyr Glu
                1125                1130                1135    
Asp Asp Lys Pro Thr Asn Tyr Ser Glu Arg Tyr Ser Glu Glu Glu Gln
            1140                1145                1150        
His Glu Glu Glu Glu Arg Pro Thr Asn Tyr Ser Ile Lys Tyr Asn Glu
        1155                1160                1165            
Glu Lys Arg His Val Asp Gln Pro Ile Asp Tyr Ser Leu Lys Tyr Ala
    1170                1175                1180                
Thr Asp Ile Pro Ser Ser Gln Lys Gln Ser Phe Ser Phe Ser Lys Ser
1185                1190                1195                1200
Ser Ser Gly Gln Ser Ser Lys Thr Glu His Met Ser Ser Ser Ser Glu
                1205                1210                1215    
Asn Thr Ser Thr Pro Ser Ser Asn Ala Lys Arg Gln Asn Gln Leu His
            1220                1225                1230        
Pro Ser Ser Ala Gln Ser Arg Ser Gly Gln Pro Gln Lys Ala Ala Thr
        1235                1240                1245            
Cys Lys Val Ser Ser Ile Asn Gln Glu Thr Ile Gln Thr Tyr Cys Val
    1250                1255                1260                
Glu Asp Thr Pro Ile Cys Phe Ser Arg Cys Ser Ser Leu Ser Ser Leu
1265                1270                1275                1280
Ser Ser Ala Glu Asp Glu Ile Gly Cys Asn Gln Thr Thr Gln Glu Ala
                1285                1290                1295    
Asp Ser Ala Asn Thr Leu Gln Ile Ala Glu Ile Lys Glu Lys Ile Gly
            1300                1305                1310        
Thr Arg Ser Ala Glu Asp Pro Val Ser Glu Val Pro Ala Val Ser Gln
        1315                1320                1325            
His Pro Arg Thr Lys Ser Ser Arg Leu Gln Gly Ser Ser Leu Ser Ser
    1330                1335                1340                
Glu Ser Ala Arg His Lys Ala Val Glu Phe Ser Ser Gly Ala Lys Ser
1345                1350                1355                1360
Pro Ser Lys Ser Gly Ala Gln Thr Pro Lys Ser Pro Pro Glu His Tyr
                1365                1370                1375    
Val Gln Glu Thr Pro Leu Met Phe Ser Arg Cys Thr Ser Val Ser Ser
            1380                1385                1390        
Leu Asp Ser Phe Glu Ser Arg Ser Ile Ala Ser Ser Val Gln Ser Glu
        1395                1400                1405            
Pro Cys Ser Gly Met Val Ser Gly Ile Ile Ser Pro Ser Asp Leu Pro
    1410                1415                1420                
Asp Ser Pro Gly Gln Thr Met Pro Pro Ser Arg Ser Lys Thr Pro Pro
1425                1430                1435                1440
Pro Pro Pro Gln Thr Ala Gln Thr Lys Arg Glu Val Pro Lys Asn Lys
                1445                1450                1455    
Ala Pro Thr Ala Glu Lys Arg Glu Ser Gly Pro Lys Gln Ala Ala Val
            1460                1465                1470        
Asn Ala Ala Val Gln Arg Val Gln Val Leu Pro Asp Ala Asp Thr Leu
        1475                1480                1485            
Leu His Phe Ala Thr Glu Ser Thr Pro Asp Gly Phe Ser Cys Ser Ser
    1490                1495                1500                
Ser Leu Ser Ala Leu Ser Leu Asp Glu Pro Phe Ile Gln Lys Asp Val
1505                1510                1515                1520
Glu Leu Arg Ile Met Pro Pro Val Gln Glu Asn Asp Asn Gly Asn Glu
                1525                1530                1535    
Thr Glu Ser Glu Gln Pro Lys Glu Ser Asn Glu Asn Gln Glu Lys Glu
            1540                1545                1550        
Ala Glu Lys Thr Ile Asp Ser Glu Lys Asp Leu Leu Asp Asp Ser Asp
        1555                1560                1565            
Asp Asp Asp Ile Glu Ile Leu Glu Glu Cys Ile Ile Ser Ala Met Pro
    1570                1575                1580                
Thr Lys Ser Ser Arg Lys Ala Lys Lys Pro Ala Gln Thr Ala Ser Lys
1585                1590                1595                1600
Leu Pro Pro Pro Val Ala Arg Lys Pro Ser Gln Leu Pro Val Tyr Lys
                1605                1610                1615    
Leu Leu Pro Ser Gln Asn Arg Leu Gln Pro Gln Lys His Val Ser Phe
            1620                1625                1630        
Thr Pro Gly Asp Asp Met Pro Arg Val Tyr Cys Val Glu Gly Thr Pro
        1635                1640                1645            
Ile Asn Phe Ser Thr Ala Thr Ser Leu Ser Asp Leu Thr Ile Glu Ser
    1650                1655                1660                
Pro Pro Asn Glu Leu Ala Ala Gly Glu Gly Val Arg Gly Gly Ala Gln
1665                1670                1675                1680
Ser Gly Glu Phe Glu Lys Arg Asp Thr Ile Pro Thr Glu Gly Arg Ser
                1685                1690                1695    
Thr Asp Glu Ala Gln Gly Gly Lys Thr Ser Ser Val Thr Ile Pro Glu
            1700                1705                1710        
Leu Asp Asp Asn Lys Ala Glu Glu Gly Asp Ile Leu Ala Glu Cys Ile
        1715                1720                1725            
Asn Ser Ala Met Pro Lys Gly Lys Ser His Lys Pro Phe Arg Val Lys
    1730                1735                1740                
Lys Ile Met Asp Gln Val Gln Gln Ala Ser Ala Ser Ser Ser Ala Pro
1745                1750                1755                1760
Asn Lys Asn Gln Leu Asp Gly Lys Lys Lys Lys Pro Thr Ser Pro Val
                1765                1770                1775    
Lys Pro Ile Pro Gln Asn Thr Glu Tyr Arg Thr Arg Val Arg Lys Asn
            1780                1785                1790        
Ala Asp Ser Lys Asn Asn Leu Asn Ala Glu Arg Val Phe Ser Asp Asn
        1795                1800                1805            
Lys Asp Ser Lys Lys Gln Asn Leu Lys Asn Asn Ser Lys Val Phe Asn
    1810                1815                1820                
Asp Lys Leu Pro Asn Asn Glu Asp Arg Val Arg Gly Ser Phe Ala Phe
1825                1830                1835                1840
Asp Ser Pro His His Tyr Thr Pro Ile Glu Gly Thr Pro Tyr Cys Phe
                1845                1850                1855    
Ser Arg Asn Asp Ser Leu Ser Ser Leu Asp Phe Asp Asp Asp Asp Val
            1860                1865                1870        
Asp Leu Ser Arg Glu Lys Ala Glu Leu Arg Lys Ala Lys Glu Asn Lys
        1875                1880                1885            
Glu Ser Glu Ala Lys Val Thr Ser His Thr Glu Leu Thr Ser Asn Gln
    1890                1895                1900                
Gln Ser Ala Asn Lys Thr Gln Ala Ile Ala Lys Gln Pro Ile Asn Arg
1905                1910                1915                1920
Gly Gln Pro Lys Pro Ile Leu Gln Lys Gln Ser Thr Phe Pro Gln Ser
                1925                1930                1935    
Ser Lys Asp Ile Pro Asp Arg Gly Ala Ala Thr Asp Glu Lys Leu Gln
            1940                1945                1950        
Asn Phe Ala Ile Glu Asn Thr Pro Val Cys Phe Ser His Asn Ser Ser
        1955                1960                1965            
Leu Ser Ser Leu Ser Asp Ile Asp Gln Glu Asn Asn Asn Lys Glu Asn
    1970                1975                1980                
Glu Pro Ile Lys Glu Thr Glu Pro Pro Asp Ser Gln Gly Glu Pro Ser
1985                1990                1995                2000
Lys Pro Gln Ala Ser Gly Tyr Ala Pro Lys Ser Phe His Val Glu Asp
                2005                2010                2015    
Thr Pro Val Cys Phe Ser Arg Asn Ser Ser Leu Ser Ser Leu Ser Ile
            2020                2025                2030        
Asp Ser Glu Asp Asp Leu Leu Gln Glu Cys Ile Ser Ser Ala Met Pro
        2035                2040                2045            
Lys Lys Lys Lys Pro Ser Arg Leu Lys Gly Asp Asn Glu Lys His Ser
    2050                2055                2060                
Pro Arg Asn Met Gly Gly Ile Leu Gly Glu Asp Leu Thr Leu Asp Leu
2065                2070                2075                2080
Lys Asp Ile Gln Arg Pro Asp Ser Glu His Gly Leu Ser Pro Asp Ser
                2085                2090                2095    
Glu Asn Phe Asp Trp Lys Ala Ile Gln Glu Gly Ala Asn Ser Ile Val
            2100                2105                2110        
Ser Ser Leu His Gln Ala Ala Ala Ala Ala Cys Leu Ser Arg Gln Ala
        2115                2120                2125            
Ser Ser Asp Ser Asp Ser Ile Leu Ser Leu Lys Ser Gly Ile Ser Leu
    2130                2135                2140                
Gly Ser Pro Phe His Leu Thr Pro Asp Gln Glu Glu Lys Pro Phe Thr
2145                2150                2155                2160
Ser Asn Lys Gly Pro Arg Ile Leu Lys Pro Gly Glu Lys Ser Thr Leu
                2165                2170                2175    
Glu Thr Lys Lys Ile Glu Ser Glu Ser Lys Gly Ile Lys Gly Gly Lys
            2180                2185                2190        
Lys Val Tyr Lys Ser Leu Ile Thr Gly Lys Val Arg Ser Asn Ser Glu
        2195                2200                2205            
Ile Ser Gly Gln Met Lys Gln Pro Leu Gln Ala Asn Met Pro Ser Ile
    2210                2215                2220                
Ser Arg Gly Arg Thr Met Ile His Ile Pro Gly Val Arg Asn Ser Ser
2225                2230                2235                2240
Ser Ser Thr Ser Pro Val Ser Lys Lys Gly Pro Pro Leu Lys Thr Pro
                2245                2250                2255    
Ala Ser Lys Ser Pro Ser Glu Gly Gln Thr Ala Thr Thr Ser Pro Arg
            2260                2265                2270        
Gly Ala Lys Pro Ser Val Lys Ser Glu Leu Ser Pro Val Ala Arg Gln
        2275                2280                2285            
Thr Ser Gln Ile Gly Gly Ser Ser Lys Ala Pro Ser Arg Ser Gly Ser
    2290                2295                2300                
Arg Asp Ser Thr Pro Ser Arg Pro Ala Gln Gln Pro Leu Ser Arg Pro
2305                2310                2315                2320
Ile Gln Ser Pro Gly Arg Asn Ser Ile Ser Pro Gly Arg Asn Gly Ile
                2325                2330                2335    
Ser Pro Pro Asn Lys Leu Ser Gln Leu Pro Arg Thr Ser Ser Pro Ser
            2340                2345                2350        
Thr Ala Ser Thr Lys Ser Ser Gly Ser Gly Lys Met Ser Tyr Thr Ser
        2355                2360                2365            
Pro Gly Arg Gln Met Ser Gln Gln Asn Leu Thr Lys Gln Thr Gly Leu
    2370                2375                2380                
Ser Lys Asn Ala Ser Ser Ile Pro Arg Ser Glu Ser Ala Ser Lys Gly
2385                2390                2395                2400
Leu Asn Gln Met Asn Asn Gly Asn Gly Ala Asn Lys Lys Val Glu Leu
                2405                2410                2415    
Ser Arg Met Ser Ser Thr Lys Ser Ser Gly Ser Glu Ser Asp Arg Ser
            2420                2425                2430        
Glu Arg Pro Val Leu Val Arg Gln Ser Thr Phe Ile Lys Glu Ala Pro
        2435                2440                2445            
Ser Pro Thr Leu Arg Arg Lys Leu Glu Glu Ser Ala Ser Phe Glu Ser
    2450                2455                2460                
Leu Ser Pro Ser Ser Arg Pro Ala Ser Pro Thr Arg Ser Gln Ala Gln
2465                2470                2475                2480
Thr Pro Val Leu Ser Pro Ser Leu Pro Asp Met Ser Leu Ser Thr His
                2485                2490                2495    
Ser Ser Val Gln Ala Gly Gly Trp Arg Lys Leu Pro Pro Asn Leu Ser
            2500                2505                2510        
Pro Thr Ile Glu Tyr Asn Asp Gly Arg Pro Ala Lys Arg His Asp Ile
        2515                2520                2525            
Ala Arg Ser His Ser Glu Ser Pro Ser Arg Leu Pro Ile Asn Arg Ser
    2530                2535                2540                
Gly Thr Trp Lys Arg Glu His Ser Lys His Ser Ser Ser Leu Pro Arg
2545                2550                2555                2560
Val Ser Thr Trp Arg Arg Thr Gly Ser Ser Ser Ser Ile Leu Ser Ala
                2565                2570                2575    
Ser Ser Glu Ser Ser Glu Lys Ala Lys Ser Glu Asp Glu Lys His Val
            2580                2585                2590        
Asn Ser Ile Ser Gly Thr Lys Gln Ser Lys Glu Asn Gln Val Ser Ala
        2595                2600                2605            
Lys Gly Thr Trp Arg Lys Ile Lys Glu Asn Glu Phe Ser Pro Thr Asn
    2610                2615                2620                
Ser Thr Ser Gln Thr Val Ser Ser Gly Ala Thr Asn Gly Ala Glu Ser
2625                2630                2635                2640
Lys Thr Leu Ile Tyr Gln Met Ala Pro Ala Val Ser Lys Thr Glu Asp
                2645                2650                2655    
Val Trp Val Arg Ile Glu Asp Cys Pro Ile Asn Asn Pro Arg Ser Gly
            2660                2665                2670        
Arg Ser Pro Thr Gly Asn Thr Pro Pro Val Ile Asp Ser Val Ser Glu
        2675                2680                2685            
Lys Ala Asn Pro Asn Ile Lys Asp Ser Lys Asp Asn Gln Ala Lys Gln
    2690                2695                2700                
Asn Val Gly Asn Gly Ser Val Pro Met Arg Thr Val Gly Leu Glu Asn
2705                2710                2715                2720
Arg Leu Asn Ser Phe Ile Gln Val Asp Ala Pro Asp Gln Lys Gly Thr
                2725                2730                2735    
Glu Ile Lys Pro Gly Gln Asn Asn Pro Val Pro Val Ser Glu Thr Asn
            2740                2745                2750        
Glu Ser Ser Ile Val Glu Arg Thr Pro Phe Ser Ser Ser Ser Ser Ser
        2755                2760                2765            
Lys His Ser Ser Pro Ser Gly Thr Val Ala Ala Arg Val Thr Pro Phe
    2770                2775                2780                
Asn Tyr Asn Pro Ser Pro Arg Lys Ser Ser Ala Asp Ser Thr Ser Ala
2785                2790                2795                2800
Arg Pro Ser Gln Ile Pro Thr Pro Val Asn Asn Asn Thr Lys Lys Arg
                2805                2810                2815    
Asp Ser Lys Thr Asp Ser Thr Glu Ser Ser Gly Thr Gln Ser Pro Lys
            2820                2825                2830        
Arg His Ser Gly Ser Tyr Leu Val Thr Ser Val
        2835                2840            


<210> 1971
<211> 758
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 388, 389, 390, 391, 392, 393
<223> Xaa = Any Amino Acid

<400> 1971
Met Leu Arg Ala Cys Gln Leu Ser Gly Val Thr Ala Ala Ala Gln Ser
 1               5                  10                  15      
Cys Leu Cys Gly Lys Phe Val Leu Arg Pro Leu Arg Pro Cys Arg Arg
            20                  25                  30          
Tyr Ser Thr Ser Gly Ser Ser Gly Leu Thr Thr Gly Lys Ile Ala Gly
        35                  40                  45              
Ala Gly Leu Leu Phe Val Gly Gly Gly Ile Gly Gly Thr Ile Leu Tyr
    50                  55                  60                  
Ala Lys Trp Asp Ser His Phe Arg Glu Ser Val Glu Lys Thr Ile Pro
65                  70                  75                  80  
Tyr Ser Asp Lys Leu Phe Glu Met Val Leu Gly Pro Ala Ala Tyr Asn
                85                  90                  95      
Val Pro Leu Pro Lys Lys Ser Ile Gln Ser Gly Pro Leu Lys Ile Ser
            100                 105                 110         
Ser Val Ser Glu Val Met Lys Glu Ser Lys Gln Pro Ala Ser Gln Leu
        115                 120                 125             
Gln Lys Gln Lys Gly Asp Thr Pro Ala Ser Ala Thr Ala Pro Thr Glu
    130                 135                 140                 
Ala Ala Gln Ile Ile Ser Ala Ala Gly Asp Thr Leu Ser Val Pro Ala
145                 150                 155                 160 
Pro Ala Val Gln Pro Glu Glu Ser Leu Lys Thr Asp His Pro Glu Ile
                165                 170                 175     
Gly Glu Gly Lys Pro Thr Pro Ala Leu Ser Glu Glu Ala Ser Ser Ser
            180                 185                 190         
Ser Ile Arg Glu Arg Pro Pro Glu Glu Val Ala Ala Arg Leu Ala Gln
        195                 200                 205             
Gln Glu Lys Gln Glu Gln Val Lys Ile Glu Ser Leu Ala Lys Ser Leu
    210                 215                 220                 
Glu Asp Ala Leu Arg Gln Thr Ala Ser Val Thr Leu Gln Ala Ile Ala
225                 230                 235                 240 
Ala Gln Asn Ala Ala Val Gln Ala Val Asn Ala His Ser Asn Ile Leu
                245                 250                 255     
Lys Ala Ala Met Asp Asn Ser Glu Ile Ala Gly Glu Lys Lys Ser Ala
            260                 265                 270         
Gln Trp Arg Thr Val Glu Gly Ala Leu Lys Glu Arg Arg Lys Ala Val
        275                 280                 285             
Asp Glu Ala Ala Asp Ala Leu Leu Lys Ala Lys Glu Glu Leu Glu Lys
    290                 295                 300                 
Met Lys Ser Val Ile Glu Asn Ala Lys Lys Lys Glu Val Ala Gly Ala
305                 310                 315                 320 
Lys Pro His Ile Thr Ala Ala Glu Gly Lys Leu His Asn Met Ile Val
                325                 330                 335     
Asp Leu Asp Asn Val Val Lys Lys Val Gln Ala Ala Gln Ser Glu Ala
            340                 345                 350         
Lys Val Val Ser Gln Tyr His Glu Leu Val Val Gln Ala Arg Asp Asp
        355                 360                 365             
Phe Lys Arg Glu Leu Asp Ser Ile Thr Pro Glu Val Leu Pro Gly Trp
    370                 375                 380                 
Lys Gly Met Xaa Xaa Xaa Xaa Xaa Xaa Asp Lys Leu Ser Thr Asp Asp
385                 390                 395                 400 
Leu Asn Ser Leu Ile Ala His Ala His Arg Arg Ile Asp Gln Leu Asn
                405                 410                 415     
Arg Glu Leu Ala Glu Gln Lys Ala Thr Glu Lys Gln His Ile Thr Leu
            420                 425                 430         
Ala Leu Glu Lys Gln Lys Leu Glu Glu Lys Arg Ala Phe Asp Ser Ala
        435                 440                 445             
Val Ala Lys Ala Leu Glu His His Arg Ser Glu Ile Gln Ala Glu Gln
    450                 455                 460                 
Asp Arg Lys Ile Glu Glu Val Arg Asp Ala Met Glu Asn Glu Met Arg
465                 470                 475                 480 
Thr Gln Leu Arg Arg Gln Ala Ala Ala His Thr Asp His Leu Arg Asp
                485                 490                 495     
Val Leu Arg Val Gln Glu Gln Glu Leu Lys Ser Glu Phe Glu Gln Asn
            500                 505                 510         
Leu Ser Glu Lys Leu Ser Glu Gln Glu Leu Gln Phe Arg Arg Leu Ser
        515                 520                 525             
Gln Glu Gln Val Asp Asn Phe Thr Leu Asp Ile Asn Thr Ala Tyr Ala
    530                 535                 540                 
Arg Leu Arg Gly Ile Glu Gln Ala Val Gln Ser His Ala Val Ala Glu
545                 550                 555                 560 
Glu Glu Ala Arg Lys Ala His Gln Leu Trp Leu Ser Val Glu Ala Leu
                565                 570                 575     
Lys Tyr Ser Met Lys Thr Ser Ser Ala Glu Thr Pro Thr Ile Pro Leu
            580                 585                 590         
Gly Ser Ala Val Glu Ala Ile Lys Ala Asn Cys Ser Asp Asn Glu Phe
        595                 600                 605             
Thr Gln Ala Leu Thr Ala Ala Ile Pro Pro Glu Ser Leu Thr Arg Gly
    610                 615                 620                 
Val Tyr Ser Glu Glu Thr Leu Arg Ala Arg Phe Tyr Ala Val Gln Lys
625                 630                 635                 640 
Leu Ala Arg Arg Val Ala Met Ile Asp Glu Thr Arg Asn Ser Leu Tyr
                645                 650                 655     
Gln Tyr Phe Leu Ser Tyr Leu Gln Ser Leu Leu Leu Phe Pro Pro Gln
            660                 665                 670         
Gln Leu Lys Pro Pro Pro Glu Leu Cys Pro Glu Asp Ile Asn Thr Phe
        675                 680                 685             
Lys Leu Leu Ser Tyr Ala Ser Tyr Cys Ile Glu His Gly Asp Leu Glu
    690                 695                 700                 
Leu Ala Ala Lys Phe Val Asn Gln Leu Lys Gly Glu Ser Arg Arg Val
705                 710                 715                 720 
Ala Gln Asp Trp Leu Lys Glu Ala Arg Met Thr Leu Glu Thr Lys Gln
                725                 730                 735     
Ile Val Glu Ile Leu Thr Ala Tyr Ala Ser Ala Val Gly Ile Gly Thr
            740                 745                 750         
Thr Gln Val Gln Pro Glu
        755             


<210> 1972
<211> 955
<212> PRT
<213> Homo sapiens

<400> 1972
Met Ser Lys Thr Asn Lys Ser Lys Ser Gly Ser Arg Ser Ser Arg Ser
 1               5                  10                  15      
Arg Ser Ala Ser Arg Ser Arg Ser Arg Ser Phe Ser Lys Ser Arg Ser
            20                  25                  30          
Arg Ser Arg Ser Leu Ser Arg Ser Arg Lys Arg Arg Leu Ser Ser Arg
        35                  40                  45              
Ser Arg Ser Arg Ser Tyr Ser Pro Ala His Asn Arg Glu Arg Asn His
    50                  55                  60                  
Pro Arg Val Tyr Gln Asn Arg Asp Phe Arg Gly His Asn Arg Gly Tyr
65                  70                  75                  80  
Arg Arg Pro Tyr Tyr Phe Arg Gly Arg Asn Arg Gly Phe Tyr Pro Trp
                85                  90                  95      
Gly Gln Tyr Asn Arg Gly Gly Tyr Gly Asn Tyr Arg Ser Asn Trp Gln
            100                 105                 110         
Asn Tyr Arg Gln Ala Tyr Ser Pro Arg Arg Gly Arg Ser Arg Ser Arg
        115                 120                 125             
Ser Pro Lys Arg Arg Ser Pro Ser Pro Arg Ser Arg Ser His Ser Arg
    130                 135                 140                 
Asn Ser Asp Lys Ser Ser Ser Asp Arg Ser Arg Arg Ser Ser Ser Ser
145                 150                 155                 160 
Arg Ser Ser Ser Asn His Ser Arg Val Glu Ser Ser Lys Arg Lys Ser
                165                 170                 175     
Ala Lys Glu Lys Lys Ser Ser Ser Lys Asp Ser Arg Pro Ser Gln Ala
            180                 185                 190         
Ala Gly Asp Asn Gln Gly Asp Glu Ala Lys Glu Gln Thr Phe Ser Gly
        195                 200                 205             
Gly Thr Ser Gln Asp Thr Lys Ala Ser Glu Ser Ser Lys Pro Trp Pro
    210                 215                 220                 
Asp Ala Thr Tyr Gly Thr Gly Ser Ala Ser Arg Ala Ser Ala Val Ser
225                 230                 235                 240 
Glu Leu Ser Pro Arg Glu Arg Ser Pro Ala Leu Lys Ser Pro Leu Gln
                245                 250                 255     
Ser Val Val Val Arg Arg Arg Ser Pro Arg Pro Ser Pro Val Pro Lys
            260                 265                 270         
Pro Ser Pro Pro Leu Ser Ser Thr Ser Gln Met Gly Ser Thr Leu Pro
        275                 280                 285             
Ser Gly Ala Gly Tyr Gln Ser Gly Thr His Gln Gly Gln Phe Asp His
    290                 295                 300                 
Gly Ser Gly Ser Leu Ser Pro Ser Lys Lys Ser Pro Val Gly Lys Ser
305                 310                 315                 320 
Pro Pro Ser Thr Gly Ser Thr Tyr Gly Ser Ser Gln Lys Glu Glu Ser
                325                 330                 335     
Ala Ala Ser Gly Gly Ala Ala Tyr Thr Lys Arg Tyr Leu Glu Glu Gln
            340                 345                 350         
Lys Thr Glu Asn Gly Lys Asp Lys Glu Gln Lys Gln Thr Asn Thr Asp
        355                 360                 365             
Lys Glu Lys Ile Lys Glu Lys Gly Ser Phe Ser Asp Thr Gly Leu Gly
    370                 375                 380                 
Asp Gly Lys Met Lys Ser Asp Ser Phe Ala Pro Lys Thr Asp Ser Glu
385                 390                 395                 400 
Lys Pro Phe Arg Gly Ser Gln Ser Pro Lys Arg Tyr Lys Leu Arg Asp
                405                 410                 415     
Asp Phe Glu Lys Lys Met Ala Asp Phe His Lys Glu Glu Met Asp Asp
            420                 425                 430         
Gln Asp Lys Asp Lys Ala Lys Gly Arg Lys Glu Ser Glu Phe Asp Asp
        435                 440                 445             
Glu Pro Lys Phe Met Ser Lys Val Ile Gly Ala Asn Lys Asn Gln Glu
    450                 455                 460                 
Glu Glu Lys Ser Gly Lys Trp Glu Gly Leu Val Tyr Ala Pro Pro Gly
465                 470                 475                 480 
Lys Glu Lys Gln Arg Lys Thr Glu Glu Leu Glu Glu Glu Ser Phe Pro
                485                 490                 495     
Glu Arg Ser Lys Lys Glu Asp Arg Gly Lys Arg Ser Glu Gly Gly His
            500                 505                 510         
Arg Gly Phe Val Pro Glu Lys Asn Phe Arg Val Thr Ala Tyr Lys Ala
        515                 520                 525             
Val Gln Glu Lys Ser Ser Ser Pro Pro Pro Arg Lys Thr Ser Glu Ser
    530                 535                 540                 
Arg Asp Lys Leu Gly Ala Lys Gly Asp Phe Pro Thr Gly Lys Ser Ser
545                 550                 555                 560 
Phe Ser Ile Thr Arg Glu Ala Gln Val Asn Val Arg Met Asp Ser Phe
                565                 570                 575     
Asp Glu Asp Leu Ala Arg Pro Ser Gly Leu Leu Ala Gln Glu Arg Lys
            580                 585                 590         
Leu Cys Arg Asp Leu Val His Ser Asn Lys Lys Glu Gln Glu Phe Arg
        595                 600                 605             
Ser Ile Phe Gln His Ile Gln Ser Ala Gln Ser Gln Arg Ser Pro Ser
    610                 615                 620                 
Glu Leu Phe Ala Gln His Ile Val Thr Ile Val His His Val Lys Glu
625                 630                 635                 640 
His His Phe Gly Ser Ser Gly Met Thr Leu His Glu Arg Phe Thr Lys
                645                 650                 655     
Tyr Leu Lys Arg Gly Thr Glu Gln Glu Ala Ala Lys Asn Lys Lys Ser
            660                 665                 670         
Pro Glu Ile His Arg Arg Ile Asp Ile Ser Pro Ser Thr Phe Arg Lys
        675                 680                 685             
His Gly Leu Ala His Asp Glu Met Lys Ser Pro Arg Glu Pro Gly Tyr
    690                 695                 700                 
Lys Ala Glu Gly Lys Tyr Lys Asp Asp Pro Val Asp Leu Arg Leu Asp
705                 710                 715                 720 
Ile Glu Arg Arg Lys Lys His Lys Glu Arg Asp Leu Lys Arg Gly Lys
                725                 730                 735     
Ser Arg Glu Ser Val Asp Ser Arg Asp Ser Ser His Ser Arg Glu Arg
            740                 745                 750         
Ser Ala Glu Lys Thr Glu Lys Thr His Lys Gly Ser Lys Lys Gln Lys
        755                 760                 765             
Lys His Arg Arg Ala Arg Asp Arg Ser Arg Ser Ser Ser Ser Ser Ser
    770                 775                 780                 
Gln Ser Ser His Ser Tyr Lys Ala Glu Glu Tyr Thr Glu Glu Thr Glu
785                 790                 795                 800 
Glu Arg Glu Glu Ser Thr Thr Gly Phe Asp Lys Ser Arg Leu Gly Thr
                805                 810                 815     
Lys Asp Phe Val Gly Pro Ser Glu Arg Gly Gly Gly Arg Ala Arg Gly
            820                 825                 830         
Thr Phe Gln Phe Arg Ala Arg Gly Arg Gly Trp Gly Arg Gly Asn Tyr
        835                 840                 845             
Ser Gly Asn Asn Asn Asn Asn Ser Asn Asn Asp Phe Gln Lys Arg Asn
    850                 855                 860                 
Arg Glu Glu Glu Trp Asp Pro Glu Tyr Thr Pro Lys Ser Lys Lys Tyr
865                 870                 875                 880 
Tyr Leu His Asp Asp Arg Glu Gly Glu Gly Ser Asp Lys Trp Val Ser
                885                 890                 895     
Arg Gly Arg Gly Arg Gly Ala Phe Pro Arg Gly Arg Gly Arg Phe Met
            900                 905                 910         
Phe Arg Lys Ser Ser Thr Ser Pro Lys Trp Ala His Asp Lys Phe Ser
        915                 920                 925             
Gly Glu Glu Gly Glu Ile Glu Asp Asp Glu Ser Gly Thr Glu Asn Arg
    930                 935                 940                 
Glu Glu Lys Asp Asn Ile Gln Pro Thr Thr Glu
945                 950                 955 


<210> 1973
<211> 435
<212> PRT
<213> Homo sapiens

<400> 1973
Met Ile Gly Gly Leu Phe Ile Tyr Asn His Lys Gly Glu Val Leu Ile
 1               5                  10                  15      
Ser Arg Val Tyr Arg Asp Asp Ile Gly Arg Asn Ala Val Asp Ala Phe
            20                  25                  30          
Arg Val Asn Val Ile His Ala Arg Gln Gln Val Arg Ser Pro Val Thr
        35                  40                  45              
Asn Ile Ala Arg Thr Ser Phe Phe His Val Lys Arg Ser Asn Ile Trp
    50                  55                  60                  
Leu Ala Ala Val Thr Lys Gln Asn Val Asn Ala Ala Met Val Phe Glu
65                  70                  75                  80  
Phe Leu Tyr Lys Met Cys Asp Val Met Ala Ala Tyr Phe Gly Lys Ile
                85                  90                  95      
Ser Glu Glu Asn Ile Lys Asn Asn Phe Val Leu Ile Tyr Glu Leu Leu
            100                 105                 110         
Asp Glu Ile Leu Asp Phe Gly Tyr Pro Gln Asn Ser Glu Thr Gly Ala
        115                 120                 125             
Leu Lys Thr Phe Ile Thr Gln Gln Gly Ile Lys Ser Gln Met Gln Thr
    130                 135                 140                 
Lys Glu Glu Gln Ser Gln Ile Thr Ser Gln Val Thr Gly Gln Ile Gly
145                 150                 155                 160 
Trp Arg Arg Glu Gly Ile Lys Tyr Arg Arg Asn Glu Leu Phe Leu Asp
                165                 170                 175     
Val Leu Glu Ser Val Asn Leu Leu Met Ser Pro Gln Gly Gln Val Leu
            180                 185                 190         
Ser Ala His Val Ser Gly Arg Val Val Met Lys Ser Tyr Leu Ser Gly
        195                 200                 205             
Met Pro Glu Cys Lys Phe Gly Met Asn Asp Lys Ile Val Ile Glu Lys
    210                 215                 220                 
Gln Gly Lys Gly Thr Ala Asp Glu Thr Ser Lys Ser Gly Lys Gln Ser
225                 230                 235                 240 
Ile Ala Ile Asp Asp Cys Thr Phe His Gln Cys Val Arg Leu Ser Lys
                245                 250                 255     
Phe Asp Ser Glu Arg Ser Ile Ser Phe Ile Pro Pro Asp Gly Glu Phe
            260                 265                 270         
Glu Leu Met Arg Tyr Arg Thr Thr Lys Asp Ile Ile Leu Pro Phe Arg
        275                 280                 285             
Val Ile Pro Leu Val Arg Glu Val Gly Arg Thr Lys Leu Glu Val Lys
    290                 295                 300                 
Val Val Ile Lys Ser Asn Phe Lys Pro Ser Leu Leu Ala Gln Lys Ile
305                 310                 315                 320 
Glu Val Arg Ile Pro Thr Pro Leu Asn Thr Ser Gly Val Gln Val Ile
                325                 330                 335     
Cys Met Lys Gly Lys Ala Lys Tyr Lys Ala Ser Glu Asn Ala Ile Val
            340                 345                 350         
Trp Lys Ile Lys Arg Met Ala Gly Met Lys Glu Ser Gln Ile Ser Ala
        355                 360                 365             
Glu Ile Glu Leu Leu Pro Thr Asn Asp Lys Lys Lys Trp Ala Arg Pro
    370                 375                 380                 
Pro Ile Ser Met Asn Phe Glu Val Pro Phe Ala Pro Ser Gly Leu Lys
385                 390                 395                 400 
Val Arg Tyr Leu Lys Val Phe Glu Pro Lys Leu Asn Tyr Ser Asp His
                405                 410                 415     
Asp Val Ile Lys Trp Val Arg Tyr Ile Gly Arg Ser Gly Ile Tyr Glu
            420                 425                 430         
Thr Arg Cys
        435 


<210> 1974
<211> 750
<212> PRT
<213> Homo sapiens

<400> 1974
Met Gly Lys Ser Glu Ser Gln Met Asp Ile Thr Asp Ile Asn Thr Pro
 1               5                  10                  15      
Lys Pro Lys Lys Lys Gln Arg Trp Thr Pro Leu Glu Ile Ser Leu Ser
            20                  25                  30          
Val Leu Val Leu Leu Leu Thr Ile Ile Ala Val Thr Met Ile Ala Leu
        35                  40                  45              
Tyr Ala Thr Tyr Asp Asp Gly Ile Cys Lys Ser Ser Asp Cys Ile Lys
    50                  55                  60                  
Ser Ala Ala Arg Leu Ile Gln Asn Met Asp Ala Thr Thr Glu Pro Cys
65                  70                  75                  80  
Thr Asp Phe Phe Lys Tyr Ala Cys Gly Gly Trp Leu Lys Arg Asn Val
                85                  90                  95      
Ile Pro Glu Thr Ser Ser Arg Tyr Gly Asn Phe Asp Ile Leu Arg Asp
            100                 105                 110         
Glu Leu Glu Val Val Leu Lys Asp Val Leu Gln Glu Pro Lys Thr Glu
        115                 120                 125             
Asp Ile Val Ala Val Gln Lys Ala Lys Ala Leu Tyr Arg Ser Cys Ile
    130                 135                 140                 
Asn Glu Ser Ala Ile Asp Ser Arg Gly Gly Glu Pro Leu Leu Lys Leu
145                 150                 155                 160 
Leu Pro Asp Ile Tyr Gly Trp Pro Val Ala Thr Glu Asn Trp Glu Gln
                165                 170                 175     
Lys Tyr Gly Ala Ser Trp Thr Ala Glu Lys Ala Ile Ala Gln Leu Asn
            180                 185                 190         
Ser Lys Tyr Gly Lys Lys Val Leu Ile Asn Leu Phe Val Gly Thr Asp
        195                 200                 205             
Asp Lys Asn Ser Val Asn His Val Ile His Ile Asp Gln Pro Arg Leu
    210                 215                 220                 
Gly Leu Pro Ser Arg Asp Tyr Tyr Glu Cys Thr Gly Ile Tyr Lys Glu
225                 230                 235                 240 
Ala Cys Thr Ala Tyr Val Asp Phe Met Ile Ser Val Ala Arg Leu Ile
                245                 250                 255     
Arg Gln Glu Glu Arg Leu Pro Ile Asp Glu Asn Gln Leu Ala Leu Glu
            260                 265                 270         
Met Asn Lys Val Met Glu Leu Glu Lys Glu Ile Ala Asn Ala Thr Ala
        275                 280                 285             
Lys Pro Glu Asp Arg Asn Asp Pro Met Leu Leu Tyr Asn Lys Met Thr
    290                 295                 300                 
Leu Ala Gln Ile Gln Asn Asn Phe Ser Leu Glu Ile Asn Gly Lys Pro
305                 310                 315                 320 
Phe Ser Trp Leu Asn Phe Thr Asn Glu Ile Met Ser Thr Val Asn Ile
                325                 330                 335     
Ser Ile Thr Asn Glu Glu Asp Val Val Val Tyr Ala Pro Glu Tyr Leu
            340                 345                 350         
Thr Lys Leu Lys Pro Ile Leu Thr Lys Tyr Ser Ala Arg Asp Leu Gln
        355                 360                 365             
Asn Leu Met Ser Trp Arg Phe Ile Met Asp Leu Val Ser Ser Leu Ser
    370                 375                 380                 
Arg Thr Tyr Lys Glu Ser Arg Asn Ala Phe Arg Lys Ala Leu Tyr Gly
385                 390                 395                 400 
Thr Thr Ser Glu Thr Ala Thr Trp Arg Arg Cys Ala Asn Tyr Val Asn
                405                 410                 415     
Gly Asn Met Glu Asn Ala Val Gly Arg Leu Tyr Val Glu Ala Ala Phe
            420                 425                 430         
Ala Gly Glu Ser Lys His Val Val Glu Asp Leu Ile Ala Gln Ile Arg
        435                 440                 445             
Glu Val Phe Ile Gln Thr Leu Asp Asp Leu Thr Trp Met Asp Ala Glu
    450                 455                 460                 
Thr Lys Lys Arg Ala Glu Glu Lys Ala Leu Ala Ile Lys Glu Arg Ile
465                 470                 475                 480 
Gly Tyr Pro Asp Asp Ile Val Ser Asn Asp Asn Lys Leu Asn Asn Glu
                485                 490                 495     
Tyr Leu Glu Leu Asn Tyr Lys Glu Asp Glu Tyr Phe Glu Asn Ile Ile
            500                 505                 510         
Gln Asn Leu Lys Phe Ser Gln Ser Lys Gln Leu Lys Lys Leu Arg Glu
        515                 520                 525             
Lys Val Asp Lys Asp Glu Trp Ile Ser Gly Ala Ala Val Val Asn Ala
    530                 535                 540                 
Phe Tyr Ser Ser Gly Arg Asn Gln Ile Val Phe Pro Ala Gly Ile Leu
545                 550                 555                 560 
Gln Pro Pro Phe Phe Ser Ala Gln Gln Ser Asn Ser Leu Asn Tyr Gly
                565                 570                 575     
Gly Ile Gly Met Val Ile Gly His Glu Ile Thr His Gly Phe Asp Asp
            580                 585                 590         
Asn Gly Arg Asn Phe Asn Lys Asp Gly Asp Leu Val Asp Trp Trp Thr
        595                 600                 605             
Gln Gln Ser Ala Ser Asn Phe Lys Glu Gln Ser Gln Cys Met Val Tyr
    610                 615                 620                 
Gln Tyr Gly Asn Phe Ser Trp Asp Leu Ala Gly Gly Gln His Leu Asn
625                 630                 635                 640 
Gly Ile Asn Thr Leu Gly Glu Asn Ile Ala Asp Asn Gly Gly Leu Gly
                645                 650                 655     
Gln Ala Tyr Arg Ala Tyr Gln Asn Tyr Ile Lys Lys Asn Gly Glu Glu
            660                 665                 670         
Lys Leu Leu Pro Gly Leu Asp Leu Asn His Lys Gln Leu Phe Phe Leu
        675                 680                 685             
Asn Phe Ala Gln Val Trp Cys Gly Thr Tyr Arg Pro Glu Tyr Ala Val
    690                 695                 700                 
Asn Ser Ile Lys Thr Asp Val His Ser Pro Gly Asn Phe Arg Ile Ile
705                 710                 715                 720 
Gly Thr Leu Gln Asn Ser Ala Glu Phe Ser Glu Ala Phe His Cys Arg
                725                 730                 735     
Lys Asn Ser Tyr Met Asn Pro Glu Lys Lys Cys Arg Val Trp
            740                 745                 750 


<210> 1975
<211> 379
<212> PRT
<213> Homo sapiens

<400> 1975
Met Ala Gly Asp Gly Arg Arg Ala Glu Ala Val Arg Glu Gly Trp Gly
 1               5                  10                  15      
Val Tyr Val Thr Pro Arg Ala Pro Ile Arg Glu Gly Arg Gly Arg Leu
            20                  25                  30          
Ala Pro Gln Asn Gly Gly Ser Ser Asp Ala Pro Ala Tyr Arg Thr Pro
        35                  40                  45              
Pro Ser Arg Gln Gly Arg Arg Glu Val Arg Phe Ser Asp Glu Pro Pro
    50                  55                  60                  
Glu Val Tyr Gly Asp Phe Glu Pro Leu Val Ala Lys Glu Arg Ser Pro
65                  70                  75                  80  
Val Gly Lys Arg Thr Arg Leu Glu Glu Phe Arg Ser Asp Ser Ala Lys
                85                  90                  95      
Glu Glu Val Arg Glu Ser Ala Tyr Tyr Leu Arg Ser Arg Gln Arg Arg
            100                 105                 110         
Gln Pro Arg Pro Gln Glu Thr Glu Glu Met Lys Thr Arg Arg Thr Thr
        115                 120                 125             
Arg Leu Gln Gln Gln His Ser Glu Gln Pro Pro Leu Gln Pro Ser Pro
    130                 135                 140                 
Val Met Thr Arg Arg Gly Leu Arg Asp Ser His Ser Ser Glu Glu Asp
145                 150                 155                 160 
Glu Ala Ser Ser Gln Thr Asp Leu Ser Gln Thr Ile Ser Lys Lys Thr
                165                 170                 175     
Val Arg Ser Ile Gln Glu Ala Pro Ala Val Ser Glu Asp Leu Val Ile
            180                 185                 190         
Arg Leu Arg Arg Pro Pro Leu Arg Tyr Pro Arg Tyr Glu Ala Thr Ser
        195                 200                 205             
Val Gln Gln Lys Val Asn Phe Ser Glu Glu Gly Glu Thr Glu Glu Asp
    210                 215                 220                 
Asp Gln Asp Ser Ser His Ser Ser Val Thr Thr Val Lys Ala Arg Ser
225                 230                 235                 240 
Arg Asp Ser Asp Glu Ser Gly Asp Lys Thr Thr Arg Ser Ser Ser Gln
                245                 250                 255     
Tyr Ile Glu Ser Phe Trp Gln Ser Ser Gln Ser Gln Asn Phe Thr Ala
            260                 265                 270         
His Asp Lys Gln Pro Ser Val Leu Thr Ala Gly Ser Thr Leu Ile Phe
        275                 280                 285             
Tyr Lys Tyr Cys Asp His Glu Asn Ala Ala Phe Lys Asp Val Ala Leu
    290                 295                 300                 
Val Leu Thr Val Leu Leu Glu Glu Glu Thr Leu Gly Thr Ser Leu Gly
305                 310                 315                 320 
Leu Lys Glu Val Glu Glu Lys Val Arg Asp Phe Leu Lys Val Lys Phe
                325                 330                 335     
Thr Asn Ser Asn Thr Pro Asn Ser Tyr Asn His Met Asp Pro Asp Lys
            340                 345                 350         
Leu Asn Gly Leu Trp Ser Arg Ile Ser His Leu Val Leu Pro Val Gln
        355                 360                 365             
Pro Glu Asn Ala Leu Lys Arg Gly Ile Cys Leu
    370                 375                 


<210> 1976
<211> 142
<212> PRT
<213> Homo sapiens

<400> 1976
Met Ala Ala Val Val Ala Ala Thr Ala Leu Lys Gly Arg Gly Ala Arg
 1               5                  10                  15      
Asn Ala Arg Val Leu Arg Gly Ile Leu Ala Gly Ala Thr Ala Asn Lys
            20                  25                  30          
Ala Ser His Asn Arg Thr Arg Ala Leu Gln Ser His Ser Ser Pro Glu
        35                  40                  45              
Gly Lys Glu Glu Pro Glu Pro Leu Ser Pro Glu Leu Glu Tyr Ile Pro
    50                  55                  60                  
Arg Lys Arg Gly Lys Asn Pro Met Lys Ala Val Gly Leu Ala Trp Ala
65                  70                  75                  80  
Ile Gly Phe Pro Cys Gly Ile Leu Leu Phe Ile Leu Thr Lys Arg Glu
                85                  90                  95      
Val Asp Lys Asp Arg Val Lys Gln Met Lys Ala Arg Gln Asn Met Arg
            100                 105                 110         
Leu Ser Asn Thr Gly Glu Tyr Glu Ser Gln Arg Phe Arg Ala Ser Ser
        115                 120                 125             
Gln Ser Ala Pro Ser Pro Asp Val Gly Ser Gly Val Gln Thr
    130                 135                 140         


<210> 1977
<211> 3024
<212> PRT
<213> Homo sapiens

<400> 1977
Met Val Ser Asp Arg Thr Thr Pro Ile Ile Pro Leu Val Asp Glu Leu
 1               5                  10                  15      
Pro Val Ile Pro Thr Glu Phe Pro Pro Val Gly Asn Ile Val Ser Phe
            20                  25                  30          
Glu Gln Lys Ala Thr Val Gln Pro Gln Ala Ile Thr Asp Ser Leu Ala
        35                  40                  45              
Thr Lys Leu Pro Thr Pro Thr Gly Ser Thr Lys Lys Pro Trp Asp Met
    50                  55                  60                  
Asp Asp Tyr Ser Pro Ser Ala Ser Gly Pro Leu Gly Lys Leu Asp Ile
65                  70                  75                  80  
Ser Glu Ile Lys Glu Glu Val Leu Gln Ser Thr Thr Gly Val Ser His
                85                  90                  95      
Tyr Ala Thr Asp Ser Trp Asp Gly Val Val Glu Asp Lys Gln Thr Gln
            100                 105                 110         
Glu Ser Val Thr Gln Ile Glu Gln Ile Glu Val Gly Pro Leu Val Thr
        115                 120                 125             
Ser Met Glu Ile Leu Lys His Ile Pro Ser Lys Glu Phe Pro Val Thr
    130                 135                 140                 
Glu Thr Pro Leu Val Thr Ala Arg Met Ile Leu Glu Ser Lys Thr Glu
145                 150                 155                 160 
Lys Lys Met Val Ser Thr Val Ser Glu Leu Val Thr Thr Gly His Tyr
                165                 170                 175     
Gly Phe Thr Leu Gly Glu Glu Asp Asp Glu Asp Arg Thr Leu Thr Val
            180                 185                 190         
Gly Ser Asp Glu Ser Thr Leu Ile Phe Asp Gln Ile Pro Glu Val Ile
        195                 200                 205             
Thr Val Ser Lys Thr Ser Glu Asp Thr Ile His Thr His Leu Glu Asp
    210                 215                 220                 
Leu Glu Ser Val Ser Ala Ser Thr Thr Val Ser Pro Leu Ile Met Pro
225                 230                 235                 240 
Asp Asn Asn Gly Ser Ser Met Asp Asp Trp Glu Glu Arg Gln Thr Ser
                245                 250                 255     
Gly Arg Ile Thr Glu Glu Phe Leu Gly Lys Tyr Leu Ser Thr Thr Pro
            260                 265                 270         
Phe Pro Ser Gln His Arg Thr Glu Ile Glu Leu Phe Pro Tyr Ser Gly
        275                 280                 285             
Asp Lys Ile Leu Val Glu Gly Ile Ser Thr Val Ile Tyr Pro Ser Leu
    290                 295                 300                 
Gln Thr Glu Met Thr His Arg Arg Glu Arg Thr Glu Thr Leu Ile Pro
305                 310                 315                 320 
Glu Met Arg Thr Asp Thr Tyr Thr Asp Glu Ile Gln Glu Glu Ile Thr
                325                 330                 335     
Lys Ser Pro Phe Met Gly Lys Thr Glu Glu Glu Val Phe Ser Gly Met
            340                 345                 350         
Lys Leu Ser Thr Ser Leu Ser Glu Pro Ile His Val Thr Glu Ser Ser
        355                 360                 365             
Val Glu Met Thr Lys Ser Phe Asp Phe Pro Thr Leu Ile Thr Lys Leu
    370                 375                 380                 
Ser Ala Glu Pro Thr Glu Val Arg Asp Met Glu Glu Asp Phe Thr Ala
385                 390                 395                 400 
Thr Pro Gly Thr Thr Lys Tyr Asp Glu Asn Ile Thr Thr Val Leu Leu
                405                 410                 415     
Ala His Gly Thr Leu Ser Val Glu Ala Ala Thr Val Ser Lys Trp Ser
            420                 425                 430         
Trp Asp Glu Asp Asn Thr Thr Ser Lys Pro Leu Glu Ser Thr Glu Pro
        435                 440                 445             
Ser Ala Ser Ser Lys Leu Pro Pro Ala Leu Leu Thr Thr Val Gly Met
    450                 455                 460                 
Asn Gly Lys Asp Lys Asp Ile Pro Ser Phe Thr Glu Asp Gly Ala Asp
465                 470                 475                 480 
Glu Phe Thr Leu Ile Pro Asp Ser Thr Gln Lys Gln Leu Glu Glu Val
                485                 490                 495     
Thr Asp Glu Asp Ile Ala Ala His Gly Lys Phe Thr Ile Arg Phe Gln
            500                 505                 510         
Pro Thr Thr Ser Thr Gly Ile Ala Glu Lys Ser Thr Leu Arg Asp Ser
        515                 520                 525             
Thr Thr Glu Glu Lys Val Pro Pro Ile Thr Ser Thr Glu Gly Gln Val
    530                 535                 540                 
Tyr Ala Thr Met Glu Gly Ser Ala Leu Gly Glu Val Glu Asp Val Asp
545                 550                 555                 560 
Leu Ser Lys Pro Val Ser Thr Val Pro Gln Phe Ala His Thr Ser Glu
                565                 570                 575     
Val Glu Gly Leu Ala Phe Val Ser Tyr Ser Ser Thr Gln Glu Pro Thr
            580                 585                 590         
Thr Tyr Val Asp Ser Ser His Thr Ile Pro Leu Ser Val Ile Pro Lys
        595                 600                 605             
Thr Asp Trp Gly Val Leu Val Pro Ser Val Pro Ser Glu Asp Glu Val
    610                 615                 620                 
Leu Gly Glu Pro Ser Gln Asp Ile Leu Val Ile Asp Gln Thr Arg Leu
625                 630                 635                 640 
Glu Ala Thr Ile Ser Pro Glu Thr Met Arg Thr Thr Lys Ile Thr Glu
                645                 650                 655     
Gly Thr Thr Gln Glu Glu Phe Pro Trp Lys Glu Gln Thr Ala Glu Lys
            660                 665                 670         
Pro Val Pro Ala Leu Ser Ser Thr Ala Trp Thr Pro Lys Glu Ala Val
        675                 680                 685             
Thr Pro Leu Asp Glu Gln Glu Gly Asp Gly Ser Ala Tyr Thr Val Ser
    690                 695                 700                 
Glu Asp Glu Leu Leu Thr Gly Ser Glu Arg Val Pro Val Leu Glu Thr
705                 710                 715                 720 
Thr Pro Val Gly Lys Ile Asp His Ser Val Ser Tyr Pro Pro Gly Ala
                725                 730                 735     
Val Thr Glu His Lys Val Lys Thr Asp Glu Val Val Thr Leu Thr Pro
            740                 745                 750         
Arg Ile Gly Pro Lys Val Ser Leu Ser Pro Gly Pro Glu Gln Lys Tyr
        755                 760                 765             
Glu Thr Glu Gly Ser Ser Thr Thr Gly Phe Thr Ser Ser Leu Ser Pro
    770                 775                 780                 
Phe Ser Thr His Ile Thr Gln Leu Met Glu Glu Thr Thr Thr Glu Lys
785                 790                 795                 800 
Thr Ser Leu Glu Asp Ile Asp Leu Gly Ser Gly Leu Phe Glu Lys Pro
                805                 810                 815     
Lys Ala Thr Glu Leu Ile Glu Phe Ser Thr Ile Lys Val Thr Val Pro
            820                 825                 830         
Ser Asp Ile Thr Thr Ala Phe Ser Ser Val Asp Arg Leu His Thr Thr
        835                 840                 845             
Ser Ala Phe Lys Pro Ser Ser Ala Ile Thr Lys Lys Pro Pro Leu Ile
    850                 855                 860                 
Asp Arg Glu Pro Gly Glu Glu Thr Thr Ser Asp Met Val Ile Ile Gly
865                 870                 875                 880 
Glu Ser Thr Ser His Val Pro Pro Thr Thr Leu Glu Asp Ile Val Ala
                885                 890                 895     
Lys Glu Thr Glu Thr Asp Ile Asp Arg Glu Tyr Phe Thr Thr Ser Ser
            900                 905                 910         
Pro Pro Ala Thr Gln Pro Thr Arg Pro Pro Thr Val Glu Asp Lys Glu
        915                 920                 925             
Ala Phe Gly Pro Gln Ala Leu Ser Thr Pro Gln Pro Pro Ala Ser Thr
    930                 935                 940                 
Lys Phe His Pro Asp Ile Asn Val Tyr Ile Ile Glu Val Arg Glu Asn
945                 950                 955                 960 
Lys Thr Gly Arg Met Ser Asp Leu Ser Val Ile Gly His Pro Ile Asp
                965                 970                 975     
Ser Glu Ser Lys Glu Asp Glu Pro Cys Ser Glu Glu Thr Asp Pro Val
            980                 985                 990         
His Asp Leu Met Ala Glu Ile Leu Pro Glu Phe Pro Asp Ile Ile Glu
        995                 1000                1005            
Ile Asp Leu Tyr His Ser Glu Glu Asn Glu Glu Glu Glu Glu Glu Cys
    1010                1015                1020                
Ala Asn Ala Thr Asp Val Thr Thr Thr Pro Ser Val Gln Tyr Ile Asn
1025                1030                1035                1040
Gly Lys His Leu Val Thr Thr Val Pro Lys Asp Pro Glu Ala Ala Glu
                1045                1050                1055    
Ala Arg Arg Gly Gln Phe Glu Ser Val Ala Pro Ser Gln Asn Phe Ser
            1060                1065                1070        
Asp Ser Ser Glu Ser Asp Thr His Pro Phe Val Ile Ala Lys Thr Glu
        1075                1080                1085            
Leu Ser Thr Ala Val Gln Pro Asn Glu Ser Thr Glu Thr Thr Glu Ser
    1090                1095                1100                
Leu Glu Val Thr Trp Lys Pro Glu Thr Tyr Pro Glu Thr Ser Glu His
1105                1110                1115                1120
Phe Ser Gly Gly Glu Pro Asp Val Phe Pro Thr Val Pro Phe His Glu
                1125                1130                1135    
Glu Phe Glu Ser Gly Thr Ala Lys Lys Gly Ala Glu Ser Val Thr Glu
            1140                1145                1150        
Arg Asp Thr Glu Val Gly His Gln Ala His Glu His Thr Glu Pro Val
        1155                1160                1165            
Ser Leu Phe Pro Glu Glu Ser Ser Gly Glu Ile Ala Ile Asp Gln Glu
    1170                1175                1180                
Ser Gln Lys Ile Ala Phe Ala Arg Ala Thr Glu Val Thr Phe Gly Glu
1185                1190                1195                1200
Glu Val Glu Lys Ser Thr Ser Val Thr Tyr Thr Pro Thr Ile Val Pro
                1205                1210                1215    
Ser Ser Ala Ser Ala Tyr Val Ser Glu Glu Glu Ala Val Thr Leu Ile
            1220                1225                1230        
Gly Asn Pro Trp Pro Asp Asp Leu Leu Ser Thr Lys Glu Ser Trp Val
        1235                1240                1245            
Glu Ala Thr Pro Arg Gln Val Val Glu Leu Ser Gly Ser Ser Ser Ile
    1250                1255                1260                
Pro Ile Thr Glu Gly Ser Gly Glu Ala Glu Glu Asp Glu Asp Thr Met
1265                1270                1275                1280
Phe Thr Met Val Thr Asp Leu Ser Gln Arg Asn Thr Thr Asp Thr Leu
                1285                1290                1295    
Ile Thr Leu Asp Thr Ser Arg Ile Ile Thr Glu Ser Phe Phe Glu Val
            1300                1305                1310        
Pro Ala Thr Thr Ile Tyr Pro Val Ser Glu Gln Pro Ser Ala Lys Val
        1315                1320                1325            
Val Pro Thr Lys Phe Val Ser Glu Thr Asp Thr Ser Glu Trp Ile Ser
    1330                1335                1340                
Ser Thr Thr Val Glu Glu Lys Lys Arg Lys Glu Glu Glu Gly Thr Thr
1345                1350                1355                1360
Gly Thr Ala Ser Thr Phe Glu Val Tyr Ser Ser Thr Gln Arg Ser Asp
                1365                1370                1375    
Gln Leu Ile Leu Pro Phe Glu Leu Glu Ser Pro Asn Val Ala Thr Ser
            1380                1385                1390        
Ser Asp Ser Gly Thr Arg Lys Ser Phe Met Ser Leu Thr Thr Pro Thr
        1395                1400                1405            
Gln Ser Glu Arg Glu Met Thr Asp Ser Thr Pro Val Phe Thr Glu Thr
    1410                1415                1420                
Asn Thr Leu Glu Asn Leu Gly Ala Gln Thr Thr Glu His Ser Ser Ile
1425                1430                1435                1440
His Gln Pro Gly Val Gln Glu Gly Leu Thr Thr Leu Pro Arg Ser Pro
                1445                1450                1455    
Ala Ser Val Phe Met Glu Gln Gly Ser Gly Glu Ala Ala Ala Asp Pro
            1460                1465                1470        
Glu Thr Thr Thr Val Ser Ser Phe Ser Leu Asn Val Glu Tyr Ala Ile
        1475                1480                1485            
Gln Ala Glu Lys Glu Val Ala Gly Thr Leu Ser Pro His Val Glu Thr
    1490                1495                1500                
Thr Phe Ser Thr Glu Pro Thr Gly Leu Val Leu Ser Thr Val Met Asp
1505                1510                1515                1520
Arg Val Val Ala Glu Asn Ile Thr Gln Thr Ser Arg Glu Ile Val Ile
                1525                1530                1535    
Ser Glu Arg Leu Gly Glu Pro Asn Tyr Gly Ala Glu Ile Arg Gly Phe
            1540                1545                1550        
Ser Thr Gly Phe Pro Leu Glu Glu Asp Phe Ser Gly Asp Phe Arg Glu
        1555                1560                1565            
Tyr Ser Thr Val Ser His Pro Ile Ala Lys Glu Glu Thr Val Met Met
    1570                1575                1580                
Glu Gly Ser Gly Asp Ala Ala Phe Arg Asp Thr Gln Thr Ser Pro Ser
1585                1590                1595                1600
Thr Val Pro Thr Ser Val His Ile Ser His Ile Ser Asp Ser Glu Gly
                1605                1610                1615    
Pro Ser Ser Thr Met Val Ser Thr Ser Ala Phe Pro Trp Glu Glu Phe
            1620                1625                1630        
Thr Ser Ser Ala Glu Gly Ser Gly Glu Gln Leu Val Thr Val Ser Ser
        1635                1640                1645            
Ser Val Val Pro Val Leu Pro Ser Ala Val Gln Lys Phe Ser Gly Thr
    1650                1655                1660                
Ala Ser Ser Ile Ile Asp Glu Gly Leu Gly Glu Val Gly Thr Val Asn
1665                1670                1675                1680
Glu Ile Asp Arg Arg Ser Thr Ile Leu Pro Thr Ala Glu Val Glu Gly
                1685                1690                1695    
Thr Lys Ala Pro Val Glu Lys Glu Glu Val Lys Val Ser Gly Thr Val
            1700                1705                1710        
Ser Thr Asn Phe Pro Gln Thr Ile Glu Pro Ala Lys Leu Trp Ser Arg
        1715                1720                1725            
Gln Glu Val Asn Pro Val Arg Gln Glu Ile Glu Ser Glu Thr Thr Ser
    1730                1735                1740                
Glu Glu Gln Ile Gln Glu Glu Lys Ser Phe Glu Ser Pro Gln Asn Ser
1745                1750                1755                1760
Pro Ala Thr Glu Gln Thr Ile Phe Asp Ser Gln Thr Phe Thr Glu Thr
                1765                1770                1775    
Glu Leu Lys Thr Thr Asp Tyr Ser Val Leu Thr Thr Lys Lys Thr Tyr
            1780                1785                1790        
Ser Asp Asp Lys Glu Met Lys Glu Glu Asp Thr Ser Leu Val Asn Met
        1795                1800                1805            
Ser Thr Pro Asp Pro Asp Ala Asn Gly Leu Glu Ser Tyr Thr Thr Leu
    1810                1815                1820                
Pro Glu Ala Thr Glu Lys Ser His Phe Phe Leu Ala Thr Ala Leu Val
1825                1830                1835                1840
Thr Glu Ser Ile Pro Ala Glu His Val Val Thr Asp Ser Pro Ile Lys
                1845                1850                1855    
Lys Glu Glu Ser Thr Lys His Phe Pro Lys Gly Met Arg Pro Thr Ile
            1860                1865                1870        
Gln Glu Ser Asp Thr Glu Leu Leu Phe Ser Gly Leu Gly Ser Gly Glu
        1875                1880                1885            
Glu Val Leu Pro Thr Leu Pro Thr Glu Ser Val Asn Phe Thr Glu Val
    1890                1895                1900                
Glu Gln Ile Asn Asn Thr Leu Tyr Pro His Thr Ser Gln Val Glu Ser
1905                1910                1915                1920
Thr Ser Ser Asp Lys Ile Glu Asp Phe Asn Arg Met Glu Asn Val Ala
                1925                1930                1935    
Lys Glu Val Gly Pro Leu Val Ser Gln Thr Asp Ile Phe Glu Gly Ser
            1940                1945                1950        
Gly Ser Val Thr Ser Thr Thr Leu Ile Glu Ile Leu Ser Asp Thr Gly
        1955                1960                1965            
Ala Glu Gly Pro Thr Val Ala Pro Leu Pro Phe Ser Thr Asp Ile Gly
    1970                1975                1980                
His Pro Gln Asn Gln Thr Val Arg Trp Ala Glu Glu Ile Gln Thr Ser
1985                1990                1995                2000
Arg Pro Gln Thr Ile Thr Glu Gln Asp Ser Asn Lys Asn Ser Ser Thr
                2005                2010                2015    
Ala Glu Ile Asn Glu Thr Thr Thr Ser Ser Thr Asp Phe Leu Ala Arg
            2020                2025                2030        
Ala Tyr Gly Phe Glu Met Ala Lys Glu Phe Val Thr Ser Ala Pro Lys
        2035                2040                2045            
Pro Ser Asp Leu Tyr Tyr Glu Pro Ser Gly Glu Gly Ser Gly Glu Val
    2050                2055                2060                
Asp Ile Val Asp Ser Phe His Thr Ser Ala Thr Thr Gln Ala Thr Arg
2065                2070                2075                2080
Gln Glu Ser Ser Thr Thr Phe Val Ser Asp Gly Ser Leu Glu Lys His
                2085                2090                2095    
Pro Glu Val Pro Ser Ala Lys Ala Val Thr Ala Asp Gly Phe Pro Thr
            2100                2105                2110        
Val Ser Val Met Leu Pro Leu His Ser Glu Gln Asn Lys Ser Ser Pro
        2115                2120                2125            
Asp Pro Thr Ser Thr Leu Ser Asn Thr Val Ser Tyr Glu Arg Ser Thr
    2130                2135                2140                
Asp Gly Ser Phe Gln Asp Arg Phe Arg Glu Phe Glu Asp Ser Thr Leu
2145                2150                2155                2160
Lys Pro Asn Arg Lys Lys Pro Thr Glu Asn Ile Ile Ile Asp Leu Asp
                2165                2170                2175    
Lys Glu Asp Lys Asp Leu Ile Leu Thr Ile Thr Glu Ser Thr Ile Leu
            2180                2185                2190        
Glu Ile Leu Pro Glu Leu Thr Ser Asp Lys Asn Thr Ile Ile Asp Ile
        2195                2200                2205            
Asp His Thr Lys Pro Val Tyr Glu Asp Ile Leu Gly Met Gln Thr Asp
    2210                2215                2220                
Ile Asp Thr Glu Val Pro Ser Glu Pro His Asp Ser Asn Asp Glu Ser
2225                2230                2235                2240
Asn Asp Asp Ser Thr Gln Val Gln Glu Ile Tyr Glu Ala Ala Val Asn
                2245                2250                2255    
Leu Ser Leu Thr Glu Glu Thr Phe Glu Gly Ser Ala Asp Val Leu Ala
            2260                2265                2270        
Ser Tyr Thr Gln Ala Thr His Asp Glu Ser Met Thr Tyr Glu Asp Arg
        2275                2280                2285            
Ser Gln Leu Asp His Met Gly Phe His Phe Thr Thr Gly Ile Pro Ala
    2290                2295                2300                
Pro Ser Thr Glu Thr Glu Leu Asp Val Leu Leu Pro Thr Ala Thr Ser
2305                2310                2315                2320
Leu Pro Ile Pro Arg Lys Ser Ala Thr Val Ile Pro Glu Ile Glu Gly
                2325                2330                2335    
Ile Lys Ala Glu Ala Lys Ala Leu Asp Asp Met Phe Glu Ser Ser Thr
            2340                2345                2350        
Leu Ser Asp Gly Gln Ala Ile Ala Asp Gln Ser Glu Ile Ile Pro Thr
        2355                2360                2365            
Leu Gly Gln Phe Glu Arg Thr Gln Glu Glu Tyr Glu Asp Lys Lys His
    2370                2375                2380                
Ala Gly Pro Ser Phe Gln Pro Glu Phe Ser Ser Gly Ala Glu Glu Ala
2385                2390                2395                2400
Leu Val Asp His Thr Pro Tyr Leu Ser Ile Ala Thr Thr His Leu Met
                2405                2410                2415    
Asp Gln Ser Val Thr Glu Val Pro Asp Val Met Glu Gly Ser Asn Pro
            2420                2425                2430        
Pro Tyr Tyr Thr Asp Thr Thr Leu Ala Val Ser Thr Phe Ala Lys Leu
        2435                2440                2445            
Ser Ser Gln Thr Pro Ser Ser Pro Leu Thr Ile Tyr Ser Gly Ser Glu
    2450                2455                2460                
Ala Ser Gly His Thr Glu Ile Pro Gln Pro Ser Ala Leu Pro Gly Ile
2465                2470                2475                2480
Asp Val Gly Ser Ser Val Met Ser Pro Gln Asp Ser Phe Lys Glu Ile
                2485                2490                2495    
His Val Asn Ile Glu Ala Thr Phe Lys Pro Ser Ser Glu Glu Tyr Leu
            2500                2505                2510        
His Ile Thr Glu Pro Pro Ser Leu Ser Pro Asp Thr Lys Leu Glu Pro
        2515                2520                2525            
Ser Glu Asp Asp Gly Lys Pro Glu Leu Leu Glu Glu Met Glu Ala Ser
    2530                2535                2540                
Pro Thr Glu Leu Ile Ala Val Glu Gly Thr Glu Ile Leu Gln Asp Phe
2545                2550                2555                2560
Gln Asn Lys Thr Asp Gly Gln Val Ser Gly Glu Ala Ile Lys Met Phe
                2565                2570                2575    
Pro Thr Ile Lys Thr Pro Glu Ala Gly Thr Val Ile Thr Thr Ala Asp
            2580                2585                2590        
Glu Ile Glu Leu Glu Gly Ala Thr Gln Trp Pro His Ser Thr Ser Ala
        2595                2600                2605            
Ser Ala Thr Tyr Gly Val Glu Ala Gly Val Val Pro Trp Leu Ser Pro
    2610                2615                2620                
Gln Thr Ser Glu Arg Pro Thr Leu Ser Ser Ser Pro Glu Ile Asn Pro
2625                2630                2635                2640
Glu Thr Gln Ala Ala Leu Ile Arg Gly Gln Asp Ser Thr Ile Ala Ala
                2645                2650                2655    
Ser Glu Gln Gln Val Ala Ala Arg Ile Leu Asp Ser Asn Asp Gln Ala
            2660                2665                2670        
Thr Val Asn Pro Val Glu Phe Asn Thr Glu Val Ala Thr Pro Pro Phe
        2675                2680                2685            
Ser Leu Leu Glu Thr Ser Asn Glu Thr Asp Phe Leu Ile Gly Ile Asn
    2690                2695                2700                
Glu Glu Ser Val Glu Gly Thr Ala Ile Tyr Leu Pro Gly Pro Asp Arg
2705                2710                2715                2720
Cys Lys Met Asn Pro Cys Leu Asn Gly Gly Thr Cys Tyr Pro Thr Glu
                2725                2730                2735    
Thr Ser Tyr Val Cys Thr Cys Val Pro Gly Tyr Ser Gly Asp Gln Cys
            2740                2745                2750        
Glu Leu Asp Phe Asp Glu Cys His Ser Asn Pro Cys Arg Asn Gly Ala
        2755                2760                2765            
Thr Cys Val Asp Gly Phe Asn Thr Phe Arg Cys Leu Cys Leu Pro Ser
    2770                2775                2780                
Tyr Val Gly Ala Leu Cys Glu Gln Asp Thr Glu Thr Cys Asp Tyr Gly
2785                2790                2795                2800
Trp His Lys Phe Gln Gly Gln Cys Tyr Lys Tyr Phe Ala His Arg Arg
                2805                2810                2815    
Thr Trp Asp Ala Ala Glu Arg Glu Cys Arg Leu Gln Gly Ala His Leu
            2820                2825                2830        
Thr Ser Ile Leu Ser His Glu Glu Gln Met Phe Val Asn Arg Val Gly
        2835                2840                2845            
His Asp Tyr Gln Trp Ile Gly Leu Asn Asp Lys Met Phe Glu His Asp
    2850                2855                2860                
Phe Arg Trp Thr Asp Gly Ser Thr Leu Gln Tyr Glu Asn Trp Arg Pro
2865                2870                2875                2880
Asn Gln Pro Asp Ser Phe Phe Ser Ala Gly Glu Asp Cys Val Val Ile
                2885                2890                2895    
Ile Trp His Glu Asn Gly Gln Trp Asn Asp Val Pro Cys Asn Tyr His
            2900                2905                2910        
Leu Thr Tyr Thr Cys Lys Lys Gly Thr Val Ala Cys Gly Gln Pro Pro
        2915                2920                2925            
Val Val Glu Asn Ala Lys Thr Phe Gly Lys Met Lys Pro Arg Tyr Glu
    2930                2935                2940                
Ile Asn Ser Leu Ile Arg Tyr His Cys Lys Asp Gly Phe Ile Gln Arg
2945                2950                2955                2960
His Leu Pro Thr Ile Arg Cys Leu Gly Asn Gly Arg Trp Ala Ile Pro
                2965                2970                2975    
Lys Ile Thr Cys Met Asn Pro Ser Ala Tyr Gln Arg Thr Tyr Ser Met
            2980                2985                2990        
Lys Tyr Phe Lys Asn Ser Ser Ser Ala Lys Asp Asn Ser Ile Asn Thr
        2995                3000                3005            
Ser Lys His Asp His Arg Trp Ser Arg Arg Trp Gln Glu Ser Arg Arg
    3010                3015                3020                


<210> 1978
<211> 148
<212> PRT
<213> Homo sapiens

<400> 1978
Met Gly His Ala Leu Cys Val Cys Ser Arg Gly Thr Val Ile Ile Asp
 1               5                  10                  15      
Asn Lys Arg Tyr Leu Phe Ile Gln Lys Leu Gly Glu Gly Gly Phe Ser
            20                  25                  30          
Tyr Val Asp Leu Val Glu Gly Leu His Asp Gly His Phe Tyr Ala Leu
        35                  40                  45              
Lys Arg Ile Leu Cys His Glu Gln Gln Asp Arg Glu Glu Ala Gln Arg
    50                  55                  60                  
Glu Ala Asp Met His Arg Leu Phe Asn His Pro Asn Ile Leu Arg Leu
65                  70                  75                  80  
Val Ala Tyr Cys Leu Arg Glu Arg Gly Ala Lys His Glu Ala Trp Leu
                85                  90                  95      
Leu Leu Pro Phe Phe Lys Arg Gly Thr Leu Trp Asn Glu Ile Glu Arg
            100                 105                 110         
Leu Lys Asp Lys Gly Asn Phe Leu Thr Glu Asp Gln Ile Leu Trp Leu
        115                 120                 125             
Leu Leu Gly Ile Cys Arg Gly Leu Glu Leu Ile Met Pro Arg Val Met
    130                 135                 140                 
Pro Thr Glu Thr
145             


<210> 1979
<211> 176
<212> PRT
<213> Homo sapiens

<400> 1979
Met Ser Arg Arg Arg Lys Gly Arg Gly Leu Leu Ala Pro Lys Gly Pro
 1               5                  10                  15      
Arg Thr Ser Gln Lys Arg Ser Phe Arg Arg Gly Trp Gly Arg Leu Lys
            20                  25                  30          
Val Glu Ile Lys Ala Thr Gln Arg Ala Arg Arg Arg Arg Arg Asn Pro
        35                  40                  45              
Thr Arg Glu Lys Lys Thr Lys Lys Lys Lys Lys Arg Arg Arg Lys Gln
    50                  55                  60                  
Lys Arg Pro Gln Pro Lys Ile Leu Ser His Arg Pro Arg Arg Lys Arg
65                  70                  75                  80  
Arg Lys Arg Arg Arg Gln Gln Ser Arg Leu Tyr Asp Glu His Gln His
                85                  90                  95      
Gln Ala Gln Gly Phe Pro Ser Arg Ala Val Ala Ile Pro Met Pro Leu
            100                 105                 110         
Thr Ser Thr Asp Leu Cys Pro Pro Trp Val Gly Thr Lys Leu Leu Pro
        115                 120                 125             
Ser Leu Ala Pro Gln Lys Lys Thr Ala Ser Phe Arg Gly Pro Cys Ala
    130                 135                 140                 
Gly Gln Ala Ser Glu Pro Ala Gly Arg Leu Val Gln Gly Glu Ser Gly
145                 150                 155                 160 
Pro Ala Pro Met Thr Ser Pro His Ser Pro Asn Thr Gly Arg Phe Ile
                165                 170                 175     


<210> 1980
<211> 393
<212> PRT
<213> Homo sapiens

<400> 1980
Met Pro Gln Leu Ser Gly Gly Gly Gly Gly Gly Gly Gly Asp Pro Glu
 1               5                  10                  15      
Leu Cys Ala Thr Asp Glu Met Ile Pro Phe Lys Asp Glu Gly Asp Pro
            20                  25                  30          
Gln Lys Glu Lys Ile Phe Ala Glu Ile Ser His Pro Glu Glu Glu Gly
        35                  40                  45              
Asp Leu Ala Asp Ile Lys Ser Ser Leu Val Asn Glu Ser Glu Ile Ile
    50                  55                  60                  
Pro Ala Ser Asn Gly His Glu Val Ala Arg Gln Ala Gln Thr Ser Gln
65                  70                  75                  80  
Glu Pro Tyr His Asp Lys Ala Arg Glu His Pro Asp Asp Gly Lys His
                85                  90                  95      
Pro Asp Gly Gly Leu Tyr Asn Lys Gly Pro Ser Tyr Ser Ser Tyr Ser
            100                 105                 110         
Gly Tyr Ile Met Met Pro Asn Met Asn Asn Asp Pro Tyr Met Ser Asn
        115                 120                 125             
Gly Ser Leu Ser Pro Pro Ile Pro Arg Thr Ser Asn Lys Val Pro Val
    130                 135                 140                 
Val Gln Pro Ser His Ala Val His Pro Leu Thr Pro Leu Ile Thr Tyr
145                 150                 155                 160 
Ser Asp Glu His Phe Ser Pro Gly Ser His Pro Ser His Ile Pro Ser
                165                 170                 175     
Asp Val Asn Ser Lys Gln Gly Met Ser Arg His Pro Pro Ala Pro Asp
            180                 185                 190         
Ile Pro Thr Phe Tyr Pro Leu Ser Pro Gly Gly Val Gly Gln Ile Thr
        195                 200                 205             
Pro Pro Leu Gly Trp Gln Gly Gln Pro Val Tyr Pro Ile Thr Gly Gly
    210                 215                 220                 
Phe Arg Gln Pro Tyr Pro Ser Ser Leu Ser Val Asp Thr Ser Met Ser
225                 230                 235                 240 
Arg Phe Ser His His Met Ile Pro Gly Pro Pro Gly Pro His Thr Thr
                245                 250                 255     
Gly Ile Pro His Pro Ala Ile Val Thr Pro Gln Val Lys Gln Glu His
            260                 265                 270         
Pro His Thr Asp Ser Asp Leu Met His Val Lys Pro Gln His Glu Gln
        275                 280                 285             
Arg Lys Glu Gln Glu Pro Lys Arg Pro His Ile Lys Lys Pro Leu Asn
    290                 295                 300                 
Ala Phe Met Leu Tyr Met Lys Glu Met Arg Ala Asn Val Val Ala Glu
305                 310                 315                 320 
Cys Thr Leu Lys Glu Ser Ala Ala Ile Asn Gln Ile Leu Gly Arg Arg
                325                 330                 335     
Trp His Ala Leu Ser Arg Glu Glu Gln Ala Lys Tyr Tyr Glu Leu Ala
            340                 345                 350         
Arg Lys Glu Arg Gln Leu His Met Gln Leu Tyr Pro Gly Trp Ser Ala
        355                 360                 365             
Arg Asp Asn Tyr Val Arg Lys Arg Arg Gly Arg Glu Arg Asn Tyr Arg
    370                 375                 380                 
Asn Leu His Gln Val Gln Val Gln Glu
385                 390             


<210> 1981
<211> 1539
<212> PRT
<213> Homo sapiens

<400> 1981
Met Asp Ser Tyr Phe Lys Ala Ala Val Ser Asp Leu Asp Lys Leu Leu
 1               5                  10                  15      
Asp Asp Phe Glu Gln Asn Pro Asp Glu Gln Asp Tyr Leu Gln Asp Val
            20                  25                  30          
Gln Asn Ala Tyr Asp Ser Asn His Cys Ser Val Ser Ser Glu Leu Ala
        35                  40                  45              
Ser Ser Gln Arg Thr Ser Leu Leu Pro Lys Asp Gln Glu Cys Val Asn
    50                  55                  60                  
Ser Cys Ala Ser Ser Glu Thr Ser Tyr Gly Thr Asn Glu Ser Ser Leu
65                  70                  75                  80  
Asn Glu Lys Thr Leu Lys Gly Leu Thr Ser Ile Gln Asn Glu Lys Asn
                85                  90                  95      
Val Thr Gly Leu Asp Leu Leu Ser Ser Val Asp Gly Gly Thr Ser Asp
            100                 105                 110         
Glu Ile Gln Pro Leu Tyr Met Gly Arg Cys Ser Lys Pro Ile Cys Asp
        115                 120                 125             
Leu Ile Ser Asp Met Gly Asn Leu Val His Ala Thr Asn Ser Glu Glu
    130                 135                 140                 
Asp Ile Lys Lys Leu Leu Pro Asp Asp Phe Lys Ser Asn Ala Asp Ser
145                 150                 155                 160 
Leu Ile Gly Leu Asp Leu Ser Ser Val Ser Asp Thr Pro Cys Val Ser
                165                 170                 175     
Ser Thr Asp His Asp Ser Asp Thr Val Arg Glu Gln Gln Asn Asp Ile
            180                 185                 190         
Ser Ser Glu Leu Gln Asn Arg Glu Ile Gly Gly Ile Lys Glu Leu Gly
        195                 200                 205             
Ile Lys Val Asp Thr Thr Leu Ser Asp Ser Tyr Asn Tyr Ser Gly Thr
    210                 215                 220                 
Glu Asn Leu Lys Asp Lys Lys Ile Phe Asn Gln Leu Glu Ser Ile Val
225                 230                 235                 240 
Asp Phe Asn Met Ser Ser Ala Leu Thr Arg Gln Ser Ser Lys Met Phe
                245                 250                 255     
His Ala Lys Asp Lys Leu Gln His Lys Ser Gln Pro Cys Gly Leu Leu
            260                 265                 270         
Lys Asp Val Gly Leu Val Lys Glu Glu Val Asp Val Ala Val Ile Thr
        275                 280                 285             
Ala Ala Glu Cys Leu Lys Glu Glu Gly Lys Thr Ser Ala Leu Thr Cys
    290                 295                 300                 
Ser Leu Pro Lys Asn Glu Asp Leu Cys Leu Asn Asp Ser Asn Ser Arg
305                 310                 315                 320 
Asp Glu Asn Phe Lys Leu Pro Asp Phe Ser Phe Gln Glu Asp Lys Thr
                325                 330                 335     
Val Ile Lys Gln Ser Ala Gln Glu Asp Ser Lys Ser Leu Asp Leu Lys
            340                 345                 350         
Asp Asn Asp Val Ile Gln Asp Ser Ser Ser Ala Leu His Val Ser Ser
        355                 360                 365             
Lys Asp Val Pro Ser Ser Leu Ser Cys Leu Pro Ala Ser Gly Ser Met
    370                 375                 380                 
Cys Gly Ser Leu Ile Glu Ser Lys Ala Arg Gly Asp Phe Leu Pro Gln
385                 390                 395                 400 
His Glu His Lys Asp Asn Ile Gln Asp Ala Val Thr Ile His Glu Glu
                405                 410                 415     
Ile Gln Asn Ser Val Val Leu Gly Gly Glu Pro Phe Lys Glu Asn Asp
            420                 425                 430         
Leu Leu Lys Gln Glu Lys Cys Lys Ser Ile Leu Leu Gln Ser Leu Ile
        435                 440                 445             
Glu Gly Met Glu Asp Arg Lys Ile Asp Pro Asp Gln Thr Val Ile Arg
    450                 455                 460                 
Ala Glu Ser Leu Asp Gly Gly Asp Thr Ser Ser Thr Val Val Glu Ser
465                 470                 475                 480 
Gln Glu Gly Leu Ser Gly Thr His Val Pro Glu Ser Ser Asp Cys Cys
                485                 490                 495     
Glu Gly Phe Ile Asn Thr Phe Ser Ser Asn Asp Met Asp Gly Gln Asp
            500                 505                 510         
Leu Asp Tyr Phe Asn Ile Asp Glu Gly Ala Lys Ser Gly Pro Leu Ile
        515                 520                 525             
Ser Asp Ala Glu Leu Asp Ala Phe Leu Thr Glu Gln Tyr Leu Gln Thr
    530                 535                 540                 
Thr Asn Ile Lys Ser Phe Glu Glu Asn Val Asn Asp Ser Lys Ser Gln
545                 550                 555                 560 
Met Asn Gln Ile Asp Met Lys Gly Leu Asp Asp Gly Asn Ile Asn Asn
                565                 570                 575     
Ile Tyr Phe Asn Ala Glu Ala Gly Ala Ile Gly Glu Ser His Gly Ile
            580                 585                 590         
Asn Ile Ile Cys Glu Ile Val Asp Lys Gln Asn Thr Ile Glu Asn Gly
        595                 600                 605             
Leu Ser Leu Gly Glu Lys Ser Thr Ile Pro Val Gln Gln Gly Leu Pro
    610                 615                 620                 
Thr Ser Lys Ser Glu Ile Thr Asn Gln Leu Ser Val Ser Asp Ile Asn
625                 630                 635                 640 
Ser Gln Ser Val Gly Gly Ala Arg Pro Lys Gln Leu Phe Ser Leu Pro
                645                 650                 655     
Ser Arg Thr Arg Ser Ser Lys Asp Leu Asn Lys Pro Asp Val Pro Asp
            660                 665                 670         
Thr Ile Glu Ser Glu Pro Ser Thr Ala Asp Thr Val Val Pro Ile Thr
        675                 680                 685             
Cys Ala Ile Asp Ser Thr Ala Asp Pro Gln Val Ser Phe Asn Ser Asn
    690                 695                 700                 
Tyr Ile Asp Ile Glu Ser Asn Ser Glu Gly Gly Ser Ser Phe Val Thr
705                 710                 715                 720 
Ala Asn Glu Asp Ser Val Pro Glu Asn Thr Cys Lys Glu Gly Leu Val
                725                 730                 735     
Leu Gly Gln Lys Gln Pro Thr Trp Val Pro Asp Ser Glu Ala Pro Asn
            740                 745                 750         
Cys Met Asn Cys Gln Val Lys Phe Thr Phe Thr Lys Arg Arg His His
        755                 760                 765             
Cys Arg Ala Cys Gly Lys Val Phe Cys Gly Val Cys Cys Asn Arg Lys
    770                 775                 780                 
Cys Lys Leu Gln Tyr Leu Glu Lys Glu Ala Arg Val Cys Val Val Cys
785                 790                 795                 800 
Tyr Glu Thr Ile Ser Lys Ala Gln Ala Phe Glu Arg Met Met Ser Pro
                805                 810                 815     
Thr Gly Ser Asn Leu Lys Ser Asn His Ser Asp Glu Cys Thr Thr Val
            820                 825                 830         
Gln Pro Pro Gln Glu Asn Gln Thr Ser Ser Ile Pro Ser Pro Ala Thr
        835                 840                 845             
Leu Pro Val Ser Ala Leu Lys Gln Pro Gly Val Glu Gly Leu Cys Ser
    850                 855                 860                 
Lys Glu Gln Lys Arg Val Trp Phe Ala Asp Gly Ile Leu Pro Asn Gly
865                 870                 875                 880 
Glu Val Ala Asp Thr Thr Lys Leu Ser Ser Gly Ser Lys Arg Cys Ser
                885                 890                 895     
Glu Asp Phe Ser Pro Leu Ser Pro Asp Val Pro Met Thr Val Asn Thr
            900                 905                 910         
Val Asp His Ser His Ser Thr Thr Val Glu Lys Pro Asn Asn Glu Thr
        915                 920                 925             
Gly Asp Ile Thr Arg Asn Glu Ile Ile Gln Ser Pro Ile Ser Gln Val
    930                 935                 940                 
Pro Ser Val Glu Lys Leu Ser Met Asn Thr Gly Asn Glu Gly Leu Pro
945                 950                 955                 960 
Thr Ser Gly Ser Phe Thr Leu Asp Asp Asp Val Phe Ala Glu Thr Glu
                965                 970                 975     
Glu Pro Ser Ser Pro Thr Gly Val Leu Val Asn Ser Asn Leu Pro Ile
            980                 985                 990         
Ala Ser Ile Ser Asp Tyr Arg Leu Leu Cys Asp Ile Asn Lys Tyr Val
        995                 1000                1005            
Cys Asn Lys Ile Ser Leu Leu Pro Asn Asp Glu Asp Ser Leu Pro Pro
    1010                1015                1020                
Leu Leu Val Ala Ser Gly Glu Lys Gly Ser Val Pro Val Val Glu Glu
1025                1030                1035                1040
His Pro Ser His Glu Gln Ile Ile Leu Leu Leu Glu Gly Glu Ser Phe
                1045                1050                1055    
His Pro Val Thr Phe Val Leu Asn Ala Asn Leu Leu Val Asn Val Lys
            1060                1065                1070        
Phe Ile Phe Tyr Ser Ser Asp Lys Tyr Trp Tyr Phe Ser Thr Asn Gly
        1075                1080                1085            
Leu His Gly Leu Gly Gln Ala Glu Ile Ile Ile Leu Leu Leu Cys Leu
    1090                1095                1100                
Pro Asn Glu Asp Thr Ile Pro Lys Asp Ile Phe Arg Leu Phe Ile Thr
1105                1110                1115                1120
Ile Tyr Lys Asp Ala Leu Lys Gly Lys Tyr Ile Glu Asn Leu Asp Asn
                1125                1130                1135    
Ile Thr Phe Thr Glu Ser Phe Leu Ser Ser Lys Asp His Gly Gly Phe
            1140                1145                1150        
Leu Phe Ile Thr Pro Thr Phe Gln Lys Leu Asp Asp Leu Ser Leu Pro
        1155                1160                1165            
Ser Asn Pro Phe Leu Cys Gly Ile Leu Ile Gln Lys Leu Glu Ile Pro
    1170                1175                1180                
Trp Ala Lys Val Phe Pro Met Arg Leu Met Leu Arg Leu Gly Ala Glu
1185                1190                1195                1200
Tyr Lys Ala Tyr Pro Ala Pro Leu Thr Ser Ile Arg Gly Arg Lys Pro
                1205                1210                1215    
Leu Phe Gly Glu Ile Gly His Thr Ile Met Asn Leu Leu Val Asp Leu
            1220                1225                1230        
Arg Asn Tyr Gln Tyr Thr Leu His Asn Ile Asp Gln Leu Leu Ile His
        1235                1240                1245            
Met Glu Met Gly Lys Ser Cys Ile Lys Ile Pro Arg Lys Lys Tyr Ser
    1250                1255                1260                
Asp Val Met Lys Val Leu Asn Ser Ser Asn Glu His Val Ile Ser Ile
1265                1270                1275                1280
Gly Ala Ser Phe Ser Thr Glu Ala Asp Ser His Leu Val Cys Ile Gln
                1285                1290                1295    
Asn Asp Gly Ile Tyr Glu Thr Gln Ala Asn Ser Ala Thr Gly His Pro
            1300                1305                1310        
Arg Lys Val Thr Gly Ala Ser Phe Val Val Phe Asn Gly Ala Leu Lys
        1315                1320                1325            
Thr Ser Ser Gly Phe Leu Ala Lys Ser Ser Ile Val Glu Asp Gly Leu
    1330                1335                1340                
Met Val Gln Ile Thr Pro Glu Thr Met Asn Gly Leu Arg Leu Ala Leu
1345                1350                1355                1360
Arg Glu Gln Lys Asp Phe Lys Ile Thr Cys Gly Lys Val Asp Ala Val
                1365                1370                1375    
Asp Leu Arg Glu Tyr Val Asp Ile Cys Trp Val Asp Ala Glu Glu Lys
            1380                1385                1390        
Gly Asn Lys Gly Val Ile Ser Ser Val Asp Gly Ile Ser Leu Gln Gly
        1395                1400                1405            
Phe Pro Ser Glu Lys Ile Lys Leu Glu Ala Asp Phe Glu Thr Asp Glu
    1410                1415                1420                
Lys Ile Val Lys Cys Thr Glu Val Phe Tyr Phe Leu Lys Asp Gln Asp
1425                1430                1435                1440
Leu Ser Ile Leu Ser Thr Ser Tyr Gln Phe Ala Lys Glu Ile Ala Met
                1445                1450                1455    
Ala Cys Ser Ala Ala Leu Cys Pro His Leu Lys Thr Leu Lys Ser Asn
            1460                1465                1470        
Gly Met Asn Lys Ile Gly Leu Arg Val Ser Ile Asp Thr Asp Met Val
        1475                1480                1485            
Glu Phe Gln Ala Gly Ser Glu Gly Gln Leu Leu Pro Gln His Tyr Leu
    1490                1495                1500                
Asn Asp Leu Asp Ser Ala Leu Ile Pro Val Ile His Gly Gly Thr Ser
1505                1510                1515                1520
Asn Ser Ser Leu Pro Leu Glu Ile Glu Leu Val Phe Phe Ile Ile Glu
                1525                1530                1535    
His Leu Phe
            


<210> 1982
<211> 101
<212> PRT
<213> Homo sapiens

<400> 1982
Met Gly Gly Thr Thr Ser Thr Arg Arg Val Thr Phe Glu Ala Asp Glu
 1               5                  10                  15      
Asn Glu Asn Ile Thr Val Val Lys Gly Ile Arg Leu Ser Glu Asn Val
            20                  25                  30          
Ile Asp Arg Met Lys Glu Ser Ser Pro Ser Gly Ser Lys Ser Gln Arg
        35                  40                  45              
Tyr Ser Gly Ala Tyr Gly Ala Ser Val Ser Asp Glu Glu Leu Lys Arg
    50                  55                  60                  
Arg Val Ala Glu Glu Leu Ala Leu Glu Gln Ala Lys Lys Glu Ser Glu
65                  70                  75                  80  
Asp Glu Lys Arg Leu Lys Gln Pro Lys Ser Trp Thr Glu Arg Gly Leu
                85                  90                  95      
Leu Pro Met Ser Ser
            100     


<210> 1983
<211> 1424
<212> PRT
<213> Homo sapiens

<400> 1983
Met Cys Glu Asn Cys Ala Asp Leu Val Glu Val Leu Asn Glu Ile Ser
 1               5                  10                  15      
Asp Val Glu Gly Gly Asp Gly Leu Gln Leu Arg Lys Glu His Thr Leu
            20                  25                  30          
Lys Ile Phe Thr Tyr Ile Asn Ser Trp Thr Gln Arg Gln Cys Leu Cys
        35                  40                  45              
Cys Phe Lys Glu Tyr Lys His Leu Glu Ile Phe Asn Gln Val Val Cys
    50                  55                  60                  
Ala Leu Ile Asn Leu Val Ile Ala Gln Val Gln Val Leu Arg Asp Gln
65                  70                  75                  80  
Leu Cys Lys His Cys Thr Thr Ile Asn Ile Asp Ser Thr Trp Gln Asp
                85                  90                  95      
Glu Ser Asn Gln Ala Glu Glu Pro Leu Asn Ile Asp Arg Glu Cys Asn
            100                 105                 110         
Glu Gly Ser Thr Glu Arg Gln Lys Ser Ile Glu Lys Lys Ser Asn Ser
        115                 120                 125             
Thr Arg Ile Cys Asn Leu Thr Glu Glu Glu Ser Ser Lys Ser Ser Asp
    130                 135                 140                 
Pro Phe Ser Leu Trp Ser Thr Asp Glu Lys Glu Lys Leu Leu Leu Cys
145                 150                 155                 160 
Val Ala Lys Ile Phe Gln Ile Gln Phe Pro Leu Tyr Thr Ala Tyr Lys
                165                 170                 175     
His Asn Thr His Pro Thr Ile Glu Asp Ile Ser Thr Gln Glu Ser Asn
            180                 185                 190         
Ile Leu Gly Ala Phe Cys Asp Met Asn Asp Val Glu Val Pro Leu His
        195                 200                 205             
Leu Leu Arg Tyr Val Cys Leu Phe Cys Gly Lys Asn Gly Leu Ser Leu
    210                 215                 220                 
Met Lys Asp Cys Phe Glu Tyr Gly Thr Pro Glu Thr Leu Pro Phe Leu
225                 230                 235                 240 
Ile Ala His Ala Phe Ile Thr Val Val Ser Asn Ile Arg Ile Trp Leu
                245                 250                 255     
His Ile Pro Ala Val Met Gln His Ile Ile Pro Phe Arg Thr Tyr Val
            260                 265                 270         
Ile Arg Tyr Leu Cys Lys Leu Ser Asp Gln Glu Leu Arg Gln Ser Ala
        275                 280                 285             
Ala Arg Asn Met Ala Asp Leu Met Trp Ser Thr Val Lys Glu Pro Leu
    290                 295                 300                 
Asp Thr Thr Leu Cys Phe Asp Lys Glu Ser Leu Asp Leu Ala Phe Lys
305                 310                 315                 320 
Tyr Phe Met Ser Pro Thr Leu Thr Met Arg Leu Ala Gly Leu Ser Gln
                325                 330                 335     
Ile Thr Asn Gln Leu His Thr Phe Asn Asp Val Cys Asn Asn Glu Ser
            340                 345                 350         
Leu Val Ser Asp Thr Glu Thr Ser Ile Ala Lys Glu Leu Ala Asp Trp
        355                 360                 365             
Leu Ile Ser Asn Asn Val Val Glu His Ile Phe Gly Pro Asn Leu His
    370                 375                 380                 
Ile Glu Ile Ile Lys Gln Cys Gln Val Ile Leu Asn Phe Leu Ala Ala
385                 390                 395                 400 
Glu Gly Arg Leu Ser Thr Gln His Ile Asp Cys Ile Trp Ala Ala Ala
                405                 410                 415     
Gln Leu Lys His Cys Ser Arg Tyr Ile His Asp Leu Phe Pro Ser Leu
            420                 425                 430         
Ile Lys Asn Leu Asp Pro Val Pro Leu Arg His Leu Leu Asn Leu Val
        435                 440                 445             
Ser Ala Leu Glu Pro Ser Val His Thr Glu Gln Thr Leu Tyr Leu Ala
    450                 455                 460                 
Ser Met Leu Ile Lys Ala Leu Trp Asn Asn Ala Leu Ala Ala Lys Ala
465                 470                 475                 480 
Gln Leu Ser Lys Gln Ser Ser Phe Ala Ser Leu Leu Asn Thr Asn Ile
                485                 490                 495     
Pro Ile Gly Asn Lys Lys Glu Glu Glu Glu Leu Arg Arg Thr Ala Pro
            500                 505                 510         
Ser Pro Trp Ser Pro Ala Ala Ser Pro Gln Ser Ser Asp Asn Ser Asp
        515                 520                 525             
Thr His Gln Ser Gly Gly Ser Asp Ile Glu Met Asp Glu Gln Leu Ile
    530                 535                 540                 
Asn Arg Thr Lys His Val Gln Gln Arg Leu Ser Asp Thr Glu Glu Ser
545                 550                 555                 560 
Met Gln Gly Ser Ser Asp Glu Thr Ala Asn Ser Gly Glu Asp Gly Ser
                565                 570                 575     
Ser Gly Pro Gly Ser Ser Ser Gly His Ser Asp Gly Ser Ser Asn Glu
            580                 585                 590         
Val Asn Ser Ser His Ala Ser Gln Ser Ala Gly Ser Pro Gly Ser Glu
        595                 600                 605             
Val Gln Ser Glu Asp Ile Ala Asp Ile Glu Ala Leu Lys Glu Glu Asp
    610                 615                 620                 
Glu Asp Asp Asp His Gly His Asn Pro Pro Lys Ser Ser Cys Gly Thr
625                 630                 635                 640 
Asp Leu Arg Asn Arg Lys Leu Glu Ser Gln Ala Gly Ile Cys Leu Gly
                645                 650                 655     
Asp Ser Gln Gly Met Ser Glu Arg Asn Gly Thr Ser Ser Gly Thr Gly
            660                 665                 670         
Lys Asp Leu Val Phe Asn Thr Glu Ser Leu Pro Ser Val Asp Asn Arg
        675                 680                 685             
Met Arg Met Leu Asp Ala Cys Ser His Ser Glu Asp Pro Glu His Asp
    690                 695                 700                 
Ile Ser Gly Glu Met Asn Ala Thr His Ile Ala Gln Gly Ser Gln Glu
705                 710                 715                 720 
Ser Cys Ile Thr Arg Thr Gly Asp Phe Leu Gly Glu Thr Ile Gly Asn
                725                 730                 735     
Glu Leu Phe Asn Cys Arg Gln Phe Ile Gly Pro Gln His His His His
            740                 745                 750         
His His His His His His His His Asp Gly His Met Val Asp Asp Met
        755                 760                 765             
Leu Ser Ala Asp Asp Val Ser Cys Ser Ser Ser Gln Val Ser Ala Lys
    770                 775                 780                 
Ser Glu Lys Asn Met Ala Asp Phe Asp Gly Glu Glu Ser Gly Cys Glu
785                 790                 795                 800 
Glu Glu Leu Val Gln Ile Asn Ser His Ala Glu Leu Thr Ser His Leu
                805                 810                 815     
Gln Gln His Leu Pro Asn Leu Ala Ser Ile Tyr His Glu His Leu Ser
            820                 825                 830         
Gln Gly Pro Val Val His Lys His Gln Phe Asn Ser Asn Ala Val Thr
        835                 840                 845             
Asp Ile Asn Leu Asp Asn Val Cys Lys Lys Gly Asn Thr Leu Leu Trp
    850                 855                 860                 
Asp Ile Val Gln Asp Glu Asp Ala Val Asn Leu Ser Glu Gly Leu Ile
865                 870                 875                 880 
Asn Glu Ala Glu Lys Leu Leu Cys Ser Leu Val Cys Trp Phe Thr Asp
                885                 890                 895     
Arg Gln Ile Arg Met Arg Phe Ile Glu Gly Cys Leu Glu Asn Leu Gly
            900                 905                 910         
Asn Asn Arg Ser Val Val Ile Ser Leu Arg Leu Leu Pro Lys Leu Phe
        915                 920                 925             
Gly Thr Phe Gln Gln Phe Gly Ser Ser Tyr Asp Thr His Trp Ile Thr
    930                 935                 940                 
Met Trp Ala Glu Lys Glu Leu Asn Met Met Lys Leu Phe Phe Asp Asn
945                 950                 955                 960 
Leu Val Tyr Tyr Ile Gln Thr Val Arg Glu Gly Arg Gln Lys His Ala
                965                 970                 975     
Leu Tyr Ser His Ser Ala Glu Val Gln Val Arg Leu Gln Phe Leu Thr
            980                 985                 990         
Cys Val Phe Ser Thr Leu Gly Ser Pro Asp His Phe Arg Leu Ser Leu
        995                 1000                1005            
Glu Gln Val Asp Ile Leu Trp His Cys Leu Val Glu Asp Ser Glu Cys
    1010                1015                1020                
Tyr Asp Asp Ala Leu His Trp Phe Leu Asn Gln Val Arg Ser Lys Asp
1025                1030                1035                1040
Gln His Ala Met Gly Met Glu Thr Tyr Lys His Leu Phe Leu Glu Lys
                1045                1050                1055    
Met Pro Gln Leu Lys Pro Glu Thr Ile Ser Met Thr Gly Leu Asn Leu
            1060                1065                1070        
Phe Gln His Leu Cys Asn Leu Ala Arg Leu Ala Thr Ser Ala Tyr Asp
        1075                1080                1085            
Gly Cys Ser Asn Ser Glu Leu Cys Gly Met Asp Gln Phe Trp Gly Ile
    1090                1095                1100                
Ala Leu Arg Ala Gln Ser Gly Asp Val Ser Arg Ala Ala Ile Gln Tyr
1105                1110                1115                1120
Ile Asn Ser Tyr Tyr Ile Asn Gly Lys Thr Gly Leu Glu Lys Glu Gln
                1125                1130                1135    
Glu Phe Ile Ser Lys Cys Met Glu Ser Leu Met Ile Ala Ser Ser Ser
            1140                1145                1150        
Leu Glu Gln Glu Ser His Ser Ser Leu Met Val Ile Glu Arg Gly Leu
        1155                1160                1165            
Leu Met Leu Lys Thr His Leu Glu Ala Phe Arg Arg Arg Phe Ala Tyr
    1170                1175                1180                
His Leu Arg Gln Trp Gln Ile Glu Gly Thr Gly Ile Ser Ser His Leu
1185                1190                1195                1200
Lys Ala Leu Ser Asp Lys Gln Ser Leu Pro Leu Arg Val Val Cys Gln
                1205                1210                1215    
Pro Ala Gly Leu Pro Asp Lys Met Thr Ile Glu Met Tyr Pro Ser Asp
            1220                1225                1230        
Gln Val Ala Asp Leu Arg Ala Glu Val Thr His Trp Tyr Glu Asn Leu
        1235                1240                1245            
Gln Lys Glu Gln Ile Asn Gln Gln Ala Gln Leu Gln Glu Phe Gly Gln
    1250                1255                1260                
Ser Asn Arg Lys Gly Glu Phe Pro Gly Gly Leu Met Gly Pro Val Arg
1265                1270                1275                1280
Met Ile Ser Ser Gly His Glu Leu Thr Thr Asp Tyr Asp Glu Lys Ala
                1285                1290                1295    
Leu His Glu Leu Gly Phe Lys Asp Met Gln Met Val Phe Val Ser Leu
            1300                1305                1310        
Gly Ala Pro Arg Arg Glu Arg Lys Gly Glu Gly Val Gln Leu Pro Ala
        1315                1320                1325            
Ser Cys Leu Pro Pro Pro Gln Lys Asp Asn Ile Pro Met Leu Leu Leu
    1330                1335                1340                
Leu Gln Glu Pro His Leu Thr Thr Leu Phe Asp Leu Leu Glu Met Leu
1345                1350                1355                1360
Ala Ser Phe Lys Pro Pro Ser Gly Lys Val Ala Val Asp Asp Ser Glu
                1365                1370                1375    
Ser Leu Arg Cys Glu Glu Leu His Leu His Ala Glu Asn Leu Ser Arg
            1380                1385                1390        
Arg Val Trp Glu Leu Leu Met Leu Leu Pro Thr Cys Pro Asn Met Leu
        1395                1400                1405            
Met Ala Phe Gln Asn Ile Ser Asp Glu Gln Ser Phe Lys Ser Ser Val
    1410                1415                1420                


<210> 1984
<211> 594
<212> PRT
<213> Homo sapiens

<400> 1984
Met Ala Ala Phe Ser Glu Met Gly Val Met Pro Glu Ile Ala Gln Ala
 1               5                  10                  15      
Val Glu Glu Met Asp Trp Leu Leu Pro Thr Asp Ile Gln Ala Glu Ser
            20                  25                  30          
Ile Pro Leu Ile Leu Gly Gly Gly Asp Val Leu Met Ala Ala Glu Thr
        35                  40                  45              
Gly Ser Gly Lys Thr Gly Ala Phe Ser Ile Pro Val Ile Gln Ile Val
    50                  55                  60                  
Tyr Glu Thr Leu Lys Asp Gln Gln Glu Gly Lys Lys Gly Lys Thr Thr
65                  70                  75                  80  
Ile Lys Thr Gly Ala Ser Val Leu Asn Lys Trp Gln Met Asn Pro Tyr
                85                  90                  95      
Asp Arg Gly Ser Ala Phe Ala Ile Gly Ser Asp Gly Leu Cys Cys Gln
            100                 105                 110         
Ser Arg Glu Val Lys Glu Trp His Gly Cys Arg Ala Thr Lys Gly Leu
        115                 120                 125             
Met Lys Gly Lys His Tyr Tyr Glu Val Ser Cys His Asp Gln Gly Leu
    130                 135                 140                 
Cys Arg Val Gly Trp Ser Thr Met Gln Ala Ser Leu Asp Leu Gly Thr
145                 150                 155                 160 
Asp Lys Phe Gly Phe Gly Phe Gly Gly Thr Gly Lys Lys Ser His Asn
                165                 170                 175     
Lys Gln Phe Asp Asn Tyr Gly Glu Glu Phe Thr Met His Asp Thr Ile
            180                 185                 190         
Gly Cys Tyr Leu Asp Ile Asp Lys Gly His Val Lys Phe Ser Lys Asn
        195                 200                 205             
Gly Lys Asp Leu Gly Leu Ala Phe Glu Ile Pro Pro His Met Lys Asn
    210                 215                 220                 
Gln Ala Leu Phe Pro Ala Cys Val Leu Lys Asn Ala Glu Leu Lys Phe
225                 230                 235                 240 
Asn Phe Gly Glu Glu Glu Phe Lys Phe Pro Pro Lys Asp Gly Phe Val
                245                 250                 255     
Ala Leu Ser Lys Ala Pro Asp Gly Tyr Ile Val Lys Ser Gln His Ser
            260                 265                 270         
Gly Asn Ala Gln Val Thr Gln Thr Lys Phe Leu Pro Asn Ala Pro Lys
        275                 280                 285             
Ala Leu Ile Val Glu Pro Ser Arg Glu Leu Ala Glu Gln Thr Leu Asn
    290                 295                 300                 
Asn Ile Lys Gln Phe Lys Lys Tyr Ile Asp Asn Pro Lys Leu Arg Glu
305                 310                 315                 320 
Leu Leu Ile Ile Gly Gly Val Ala Ala Arg Asp Gln Leu Ser Val Leu
                325                 330                 335     
Glu Asn Gly Val Asp Ile Val Val Gly Thr Pro Gly Arg Leu Asp Asp
            340                 345                 350         
Leu Val Ser Thr Gly Lys Leu Asn Leu Ser Gln Val Arg Phe Leu Val
        355                 360                 365             
Leu Asp Glu Ala Asp Gly Leu Leu Ser Gln Gly Tyr Ser Asp Phe Ile
    370                 375                 380                 
Asn Arg Met His Asn Gln Ile Pro Gln Val Thr Ser Asp Gly Lys Arg
385                 390                 395                 400 
Leu Gln Val Ile Val Cys Ser Ala Thr Leu His Ser Phe Asp Val Lys
                405                 410                 415     
Lys Leu Ser Glu Lys Ile Met His Phe Pro Thr Trp Val Asp Leu Lys
            420                 425                 430         
Gly Glu Asp Ser Val Pro Asp Thr Val His His Val Val Val Pro Val
        435                 440                 445             
Asn Pro Lys Thr Asp Arg Leu Trp Glu Arg Leu Gly Lys Ser His Ile
    450                 455                 460                 
Arg Thr Asp Asp Val His Ala Lys Asp Asn Thr Arg Pro Gly Ala Asn
465                 470                 475                 480 
Ser Pro Glu Met Trp Ser Glu Ala Ile Lys Ile Leu Lys Gly Glu Tyr
                485                 490                 495     
Ala Val Arg Ala Ile Lys Glu His Lys Met Asp Gln Ala Ile Ile Phe
            500                 505                 510         
Cys Arg Thr Lys Ile Asp Cys Asp Asn Leu Glu Gln Tyr Phe Ile Gln
        515                 520                 525             
Gln Gly Gly Gly Pro Asp Lys Lys Gly His Gln Phe Ser Cys Val Cys
    530                 535                 540                 
Leu His Gly Asp Arg Lys Pro His Glu Arg Lys Gln Asn Leu Glu Arg
545                 550                 555                 560 
Phe Lys Lys Gly Asp Val Arg Phe Leu Ile Cys Thr Asp Val Ala Ala
                565                 570                 575     
Arg Gly Ile Asp Ile His Gly Val Pro Tyr Gly Tyr Lys Cys His Ser
            580                 585                 590         
Ala Arg
        


<210> 1985
<211> 796
<212> PRT
<213> Homo sapiens

<400> 1985
Met Ser Leu Pro Leu Thr Glu Glu Gln Arg Lys Lys Ile Glu Glu Asn
 1               5                  10                  15      
Arg Gln Lys Ala Leu Ala Arg Thr Ala Glu Lys Leu Leu Ala Glu Gln
            20                  25                  30          
His Gln Arg Thr Ser Ser Gly Thr Ser Ile Ala Gly Asn Pro Phe Gln
        35                  40                  45              
Ala Lys Gln Gly Pro Ser Gln Asn Phe Pro Arg Glu Ser Cys Lys Pro
    50                  55                  60                  
Val Ser His Gly Val Ile Phe Lys Gln Gln Asn Leu Ser Ser Ser Ser
65                  70                  75                  80  
Asn Ala Asp Gln Arg Pro His Asp Ser His Ser Phe Gln Ala Lys Gly
                85                  90                  95      
Ile Trp Lys Lys Pro Glu Glu Met Pro Thr Ala Cys Pro Gly His Ser
            100                 105                 110         
Pro Arg Ser Gln Met Ala Leu Thr Gly Ile Ser Pro Pro Leu Ala Gln
        115                 120                 125             
Ser Pro Pro Glu Val Pro Lys Gln Gln Leu Leu Ser Tyr Glu Leu Gly
    130                 135                 140                 
Gln Gly His Ala Gln Ala Ser Pro Glu Ile Arg Phe Thr Pro Phe Ala
145                 150                 155                 160 
Asn Pro Thr His Lys Pro Leu Ala Lys Pro Lys Ser Ser Gln Glu Thr
                165                 170                 175     
Pro Ala His Ser Ser Gly Gln Pro Pro Arg Asp Ala Lys Leu Glu Ala
            180                 185                 190         
Lys Thr Ala Lys Ala Ser Pro Ser Gly Gln Asn Ile Ser Tyr Ile His
        195                 200                 205             
Ser Ser Ser Glu Ser Val Thr Pro Arg Thr Glu Gly Arg Leu Gln Gln
    210                 215                 220                 
Lys Ser Gly Ser Ser Val Gln Lys Gly Val Asn Ser Gln Lys Gly Lys
225                 230                 235                 240 
Cys Val Arg Asn Gly Asp Arg Phe Gln Val Leu Ile Gly Tyr Asn Ala
                245                 250                 255     
Glu Leu Ile Ala Val Phe Lys Thr Leu Pro Ser Lys Asn Tyr Asp Pro
            260                 265                 270         
Asp Thr Lys Thr Trp Asn Phe Ser Met Asn Asp Tyr Ser Ala Leu Met
        275                 280                 285             
Lys Ala Ala Gln Ser Leu Pro Thr Val Asn Leu Gln Pro Leu Glu Trp
    290                 295                 300                 
Ala Tyr Gly Ser Ser Glu Ser Pro Ser Thr Ser Ser Glu Gly Gln Ala
305                 310                 315                 320 
Gly Leu Pro Ser Ala Pro Ser Leu Ser Phe Val Lys Gly Arg Cys Met
                325                 330                 335     
Leu Ile Ser Arg Ala Tyr Phe Glu Ala Asp Ile Ser Tyr Ser Gln Asp
            340                 345                 350         
Leu Ile Ala Leu Phe Lys Gln Met Asp Ser Arg Arg Tyr Asp Val Lys
        355                 360                 365             
Thr Arg Lys Trp Ser Phe Leu Leu Glu Glu His Ser Lys Leu Ile Ala
    370                 375                 380                 
Lys Val Arg Cys Leu Pro Gln Val Gln Leu Asp Pro Leu Pro Thr Thr
385                 390                 395                 400 
Leu Thr Leu Ala Phe Ala Ser Gln Leu Lys Lys Thr Ser Leu Ser Leu
                405                 410                 415     
Thr Pro Asp Val Pro Glu Ala Asp Leu Ser Glu Val Asp Pro Lys Leu
            420                 425                 430         
Val Ser Asn Leu Met Pro Phe Gln Arg Ala Gly Val Asn Phe Ala Ile
        435                 440                 445             
Ala Lys Gly Gly Arg Leu Leu Leu Ala Asp Asp Met Gly Leu Gly Lys
    450                 455                 460                 
Thr Ile Gln Ala Ile Cys Ile Ala Ala Phe Tyr Arg Lys Glu Trp Pro
465                 470                 475                 480 
Leu Leu Val Val Val Pro Ser Ser Val Arg Phe Thr Trp Glu Gln Ala
                485                 490                 495     
Phe Leu Arg Trp Leu Pro Ser Leu Ser Pro Asp Cys Ile Asn Val Val
            500                 505                 510         
Val Thr Gly Lys Asp Arg Leu Thr Ala Gly Leu Ile Asn Ile Val Ser
        515                 520                 525             
Phe Asp Leu Leu Ser Lys Leu Glu Lys Gln Leu Lys Thr Pro Phe Lys
    530                 535                 540                 
Val Val Ile Ile Asp Glu Ser His Phe Leu Lys Asn Ser Arg Thr Ala
545                 550                 555                 560 
Arg Cys Arg Ala Ala Met Pro Val Leu Lys Val Ala Lys Arg Val Ile
                565                 570                 575     
Leu Leu Ser Gly Thr Pro Ala Met Ser Arg Pro Ala Glu Leu Tyr Thr
            580                 585                 590         
Gln Ile Ile Ala Val Lys Pro Thr Phe Phe Pro Gln Phe His Ala Phe
        595                 600                 605             
Gly Leu Arg Tyr Cys Asp Ala Lys Arg Met Pro Trp Gly Trp Asp Tyr
    610                 615                 620                 
Ser Gly Ser Ser Asn Leu Gly Glu Leu Lys Leu Leu Leu Glu Glu Ala
625                 630                 635                 640 
Val Met Leu Arg Arg Leu Lys Ser Asp Val Leu Ser Gln Leu Pro Ala
                645                 650                 655     
Lys Gln Arg Lys Ile Val Val Ile Ala Pro Gly Arg Ile Asn Ala Arg
            660                 665                 670         
Thr Arg Ala Ala Leu Asp Ala Ala Ala Lys Glu Met Thr Thr Lys Asp
        675                 680                 685             
Lys Thr Lys Gln Gln Gln Lys Asp Ala Leu Ile Leu Phe Phe Asn Arg
    690                 695                 700                 
Thr Ala Glu Ala Lys Ile Pro Ser Val Ile Glu Tyr Ile Leu Asp Leu
705                 710                 715                 720 
Leu Glu Ser Gly Arg Glu Lys Phe Leu Val Phe Ala His His Lys Val
                725                 730                 735     
Val Leu Asp Ala Ile Thr Gln Glu Leu Glu Arg Lys His Val Gln His
            740                 745                 750         
Ile Arg Ile Asp Gly Ser Thr Ser Ser Ala Glu Arg Glu Asp Leu Cys
        755                 760                 765             
Gln His Val Thr Thr Val Gly Glu Ala Cys Cys Gly Arg Ala Val His
    770                 775                 780                 
His Arg Cys Gln Tyr Gly Pro His Leu Leu Leu Gly
785                 790                 795     


<210> 1986
<211> 940
<212> PRT
<213> Homo sapiens

<400> 1986
Met Lys Leu Leu Gly Arg Gln Gln Pro Asp Thr Glu Leu Glu Ile Gln
 1               5                  10                  15      
Gln Lys Cys Gly Phe Ser Glu Leu Tyr Ser Trp Gln Arg Glu Arg Lys
            20                  25                  30          
Val Lys Thr Glu Phe Cys Leu His Asp Gly Pro Pro Tyr Ala Asn Gly
        35                  40                  45              
Asp Pro His Val Gly His Ala Leu Asn Lys Ile Leu Lys Asp Ile Ala
    50                  55                  60                  
Asn Arg Phe His Met Met Asn Gly Ser Lys Ile His Phe Val Pro Gly
65                  70                  75                  80  
Trp Asp Cys His Gly Leu Pro Ile Glu Ile Lys Val Leu Ser Glu Leu
                85                  90                  95      
Gly Arg Glu Ala Gln Asn Leu Ser Ala Met Glu Ile Arg Lys Lys Ala
            100                 105                 110         
Arg Ser Phe Ala Lys Ala Ala Ile Glu Lys Gln Lys Ser Ala Phe Ile
        115                 120                 125             
Arg Trp Gly Ile Met Ala Asp Trp Asn Asn Cys Tyr Tyr Thr Phe Asp
    130                 135                 140                 
Gly Lys Tyr Glu Ala Lys Gln Leu Arg Thr Phe Tyr Gln Met Tyr Asp
145                 150                 155                 160 
Lys Gly Leu Val Tyr Arg Ser Tyr Lys Pro Val Phe Trp Ser Pro Ser
                165                 170                 175     
Ser Arg Thr Ala Leu Ala Glu Ala Glu Leu Glu Tyr Asn Pro Glu His
            180                 185                 190         
Val Ser Arg Ser Ile Tyr Val Lys Phe Pro Leu Leu Lys Pro Ser Pro
        195                 200                 205             
Lys Leu Ala Ser Leu Ile Asp Gly Ser Ser Pro Val Ser Ile Leu Val
    210                 215                 220                 
Trp Thr Thr Gln Pro Trp Thr Ile Pro Ala Asn Glu Ala Val Cys Tyr
225                 230                 235                 240 
Met Pro Glu Ser Lys Tyr Ala Val Val Lys Cys Ser Lys Ser Gly Asp
                245                 250                 255     
Leu Tyr Val Leu Ala Ala Asp Lys Val Ala Ser Val Ala Ser Thr Leu
            260                 265                 270         
Glu Thr Thr Phe Glu Thr Ile Ser Thr Leu Ser Gly Val Asp Leu Glu
        275                 280                 285             
Asn Gly Thr Cys Ser His Pro Leu Ile Pro Asp Lys Ala Ser Pro Leu
    290                 295                 300                 
Leu Pro Ala Asn His Val Thr Met Ala Lys Gly Thr Gly Leu Val His
305                 310                 315                 320 
Thr Ala Pro Ala His Gly Met Glu Asp Tyr Gly Val Ala Ser Gln His
                325                 330                 335     
Asn Leu Pro Met Asp Cys Leu Val Asp Glu Asp Gly Val Phe Thr Asp
            340                 345                 350         
Val Ala Gly Pro Glu Leu Gln Asn Lys Ala Val Leu Glu Glu Gly Thr
        355                 360                 365             
Asp Val Val Ile Lys Met Leu Gln Thr Ala Lys Asn Leu Leu Lys Glu
    370                 375                 380                 
Glu Lys Leu Val His Ser Tyr Pro Tyr Asp Trp Arg Thr Lys Lys Pro
385                 390                 395                 400 
Val Val Ile Arg Ala Ser Lys Gln Trp Phe Ile Asn Ile Thr Asp Ile
                405                 410                 415     
Lys Thr Ala Ala Lys Glu Leu Leu Lys Lys Val Lys Phe Ile Pro Gly
            420                 425                 430         
Ser Ala Leu Asn Gly Met Val Glu Met Met Asp Arg Arg Pro Tyr Trp
        435                 440                 445             
Cys Ile Ser Arg Gln Arg Val Trp Gly Val Pro Ile Pro Val Phe His
    450                 455                 460                 
His Lys Thr Lys Asp Glu Tyr Leu Ile Asn Ser Gln Thr Thr Glu His
465                 470                 475                 480 
Ile Val Lys Leu Val Glu Gln His Gly Ser Asp Ile Trp Trp Thr Leu
                485                 490                 495     
Pro Pro Glu Gln Leu Leu Pro Lys Glu Val Leu Ser Glu Val Gly Gly
            500                 505                 510         
Pro Asp Ala Leu Glu Tyr Val Pro Gly Gln Asp Ile Leu Asp Ile Trp
        515                 520                 525             
Phe Asp Ser Gly Thr Ser Trp Ser Tyr Val Leu Pro Gly Pro Asp Gln
    530                 535                 540                 
Arg Ala Asp Leu Tyr Leu Glu Gly Lys Asp Gln Leu Gly Gly Trp Phe
545                 550                 555                 560 
Gln Ser Ser Leu Leu Thr Ser Val Ala Ala Arg Lys Arg Ala Pro Tyr
                565                 570                 575     
Lys Thr Val Ile Val His Gly Phe Thr Leu Gly Glu Lys Gly Glu Lys
            580                 585                 590         
Met Ser Lys Ser Leu Gly Asn Val Ile His Pro Asp Val Val Val Asn
        595                 600                 605             
Gly Gly Gln Asp Gln Ser Lys Glu Pro Pro Tyr Gly Ala Asp Val Leu
    610                 615                 620                 
Arg Trp Trp Val Ala Asp Ser Asn Val Phe Thr Glu Val Ala Ile Gly
625                 630                 635                 640 
Pro Ser Val Leu Asn Ala Ala Arg Asp Asp Ile Ser Lys Leu Arg Asn
                645                 650                 655     
Thr Leu Arg Phe Leu Leu Gly Asn Val Ala Asp Phe Asn Pro Glu Thr
            660                 665                 670         
Asp Ser Ile Pro Val Asn Asp Met Tyr Val Ile Asp Gln Tyr Met Leu
        675                 680                 685             
His Leu Leu Gln Asp Leu Ala Asn Lys Ile Thr Glu Leu Tyr Lys Gln
    690                 695                 700                 
Tyr Asp Phe Gly Lys Val Val Arg Leu Leu Arg Thr Phe Tyr Thr Arg
705                 710                 715                 720 
Glu Leu Ser Asn Phe Tyr Phe Ser Ile Ile Lys Asp Arg Leu Tyr Cys
                725                 730                 735     
Glu Lys Glu Asn Asp Pro Lys Arg Arg Ser Cys Gln Thr Ala Leu Val
            740                 745                 750         
Glu Ile Leu Asp Val Ile Val Arg Ser Phe Ala Pro Ile Leu Pro His
        755                 760                 765             
Leu Ala Glu Glu Val Phe Gln His Ile Pro Tyr Ile Lys Glu Pro Lys
    770                 775                 780                 
Ser Val Phe Arg Thr Gly Trp Ile Ser Thr Ser Ser Ile Trp Lys Lys
785                 790                 795                 800 
Pro Gly Leu Glu Glu Ala Val Glu Ser Ala Cys Ala Met Arg Asp Ser
                805                 810                 815     
Phe Leu Gly Ser Ile Pro Gly Lys Asn Ala Ala Glu Tyr Lys Val Ile
            820                 825                 830         
Thr Val Ile Glu Pro Gly Leu Leu Phe Glu Ile Ile Glu Met Leu Gln
        835                 840                 845             
Ser Glu Glu Thr Ser Ser Thr Ser Gln Leu Asn Glu Leu Met Met Ala
    850                 855                 860                 
Ser Glu Ser Thr Leu Leu Ala Gln Glu Pro Arg Glu Met Thr Ala Asp
865                 870                 875                 880 
Val Ile Glu Leu Lys Gly Lys Phe Leu Ile Asn Leu Glu Gly Gly Asp
                885                 890                 895     
Ile Arg Glu Glu Ser Ser Tyr Lys Val Ile Val Met Pro Thr Thr Lys
            900                 905                 910         
Glu Lys Cys Pro Arg Cys Trp Lys Tyr Thr Ala Glu Ser Ser Asp Thr
        915                 920                 925             
Leu Cys Pro Arg Cys Ala Glu Val Val Ser Gly Lys
    930                 935                 940 


<210> 1987
<211> 443
<212> PRT
<213> Homo sapiens

<400> 1987
Met Asp Glu Leu Leu Lys Glu Ile Gln Ala Met Ser Gln Cys Ser His
 1               5                  10                  15      
Pro Asn Val Val Thr Tyr Tyr Thr Ser Phe Val Val Lys Asp Glu Leu
            20                  25                  30          
Trp Leu Val Met Lys Leu Leu Ser Gly Gly Ser Met Leu Asp Ile Ile
        35                  40                  45              
Lys Tyr Ile Val Asn Arg Gly Glu His Lys Asn Gly Val Leu Glu Glu
    50                  55                  60                  
Ala Ile Ile Ala Thr Ile Leu Lys Glu Val Leu Glu Gly Leu Asp Tyr
65                  70                  75                  80  
Leu His Arg Asn Gly Gln Ile His Arg Asp Leu Lys Ala Gly Asn Ile
                85                  90                  95      
Leu Leu Gly Glu Asp Gly Ser Val Gln Ile Ala Asp Phe Gly Val Ser
            100                 105                 110         
Ala Phe Leu Ala Thr Gly Gly Asp Val Thr Arg Asn Lys Val Arg Lys
        115                 120                 125             
Thr Phe Val Gly Thr Pro Cys Trp Met Ala Pro Glu Val Met Glu Gln
    130                 135                 140                 
Val Arg Gly Tyr Asp Phe Lys Ala Asp Met Trp Ser Phe Gly Ile Thr
145                 150                 155                 160 
Ala Ile Glu Leu Ala Thr Gly Ala Ala Pro Tyr His Lys Tyr Pro Pro
                165                 170                 175     
Met Lys Val Leu Met Leu Thr Leu Gln Asn Asp Pro Pro Thr Leu Glu
            180                 185                 190         
Thr Gly Val Glu Asp Lys Glu Met Met Lys Lys Tyr Gly Lys Ser Phe
        195                 200                 205             
Arg Lys Leu Leu Ser Leu Cys Leu Gln Lys Asp Pro Ser Lys Arg Pro
    210                 215                 220                 
Thr Ala Ala Glu Leu Leu Lys Cys Lys Phe Phe Gln Lys Ala Lys Asn
225                 230                 235                 240 
Arg Glu Tyr Leu Ile Glu Lys Leu Leu Thr Arg Thr Pro Asp Ile Ala
                245                 250                 255     
Gln Arg Ala Lys Lys Val Arg Arg Val Pro Gly Ser Ser Gly His Leu
            260                 265                 270         
His Lys Thr Glu Asp Gly Asp Trp Glu Trp Ser Asp Asp Glu Met Asp
        275                 280                 285             
Glu Lys Ser Glu Glu Gly Lys Ala Ala Phe Ser Gln Glu Lys Ser Arg
    290                 295                 300                 
Arg Val Lys Glu Glu Asn Pro Glu Ile Ala Val Ser Ala Ser Thr Ile
305                 310                 315                 320 
Pro Glu Gln Ile Gln Ser Leu Ser Val His Asp Ser Gln Gly Pro Pro
                325                 330                 335     
Asn Ala Asn Glu Asp Tyr Arg Glu Ala Ser Ser Cys Ala Val Asn Leu
            340                 345                 350         
Val Leu Arg Leu Arg Asn Ser Arg Lys Glu Leu Asn Asp Ile Arg Phe
        355                 360                 365             
Glu Phe Thr Pro Gly Arg Asp Thr Ala Asp Gly Val Ser Gln Glu Leu
    370                 375                 380                 
Phe Ser Ala Gly Leu Val Asp Gly His Asp Val Val Ile Val Ala Ala
385                 390                 395                 400 
Asn Leu Gln Lys Ile Val Asp Asp Pro Lys Ala Leu Lys Thr Leu Thr
                405                 410                 415     
Phe Lys Leu Ala Ser Gly Cys Asp Gly Ser Glu Ile Pro Asp Glu Val
            420                 425                 430         
Lys Leu Ile Gly Phe Ala Gln Leu Ser Val Ser
        435                 440             


<210> 1988
<211> 706
<212> PRT
<213> Homo sapiens

<400> 1988
Met Ala Ser Pro Ala Asp Ser Cys Ile Gln Phe Thr Arg His Ala Ser
 1               5                  10                  15      
Asp Val Leu Leu Asn Leu Asn Arg Leu Arg Ser Arg Asp Ile Leu Thr
            20                  25                  30          
Asp Val Val Ile Val Val Ser Arg Glu Gln Phe Arg Ala His Lys Thr
        35                  40                  45              
Val Leu Met Ala Cys Ser Gly Leu Phe Tyr Ser Ile Phe Thr Asp Gln
    50                  55                  60                  
Leu Lys Cys Asn Leu Ser Val Ile Asn Leu Asp Pro Glu Ile Asn Pro
65                  70                  75                  80  
Glu Gly Phe Cys Ile Leu Leu Asp Phe Met Tyr Thr Ser Arg Leu Asn
                85                  90                  95      
Leu Arg Glu Gly Asn Ile Met Ala Val Met Ala Thr Ala Met Tyr Leu
            100                 105                 110         
Gln Met Glu His Val Val Asp Thr Cys Arg Lys Phe Ile Lys Ala Ser
        115                 120                 125             
Glu Ala Glu Met Val Ser Ala Ile Lys Pro Pro Arg Glu Glu Phe Leu
    130                 135                 140                 
Asn Ser Arg Met Leu Met Pro Gln Asp Ile Met Ala Tyr Arg Gly Arg
145                 150                 155                 160 
Glu Val Val Glu Asn Asn Leu Pro Leu Arg Ser Ala Pro Gly Cys Glu
                165                 170                 175     
Ser Arg Ala Phe Ala Pro Ser Leu Tyr Ser Gly Leu Ser Thr Pro Pro
            180                 185                 190         
Ala Ser Tyr Ser Met Tyr Ser His Leu Pro Val Ser Ser Leu Leu Phe
        195                 200                 205             
Ser Asp Glu Glu Phe Arg Asp Val Arg Met Pro Val Ala Asn Pro Phe
    210                 215                 220                 
Pro Lys Glu Arg Ala Leu Pro Cys Asp Ser Ala Arg Pro Val Pro Gly
225                 230                 235                 240 
Glu Tyr Ser Arg Pro Thr Leu Glu Val Ser Pro Asn Val Cys His Ser
                245                 250                 255     
Asn Ile Tyr Ser Pro Lys Glu Thr Ile Pro Glu Glu Ala Arg Ser Asp
            260                 265                 270         
Met His Tyr Ser Val Ala Glu Gly Leu Lys Pro Ala Ala Pro Ser Ala
        275                 280                 285             
Arg Asn Ala Pro Tyr Phe Pro Cys Asp Lys Ala Ser Lys Glu Glu Glu
    290                 295                 300                 
Arg Pro Ser Ser Glu Asp Glu Ile Ala Leu His Phe Glu Pro Pro Asn
305                 310                 315                 320 
Ala Pro Leu Asn Arg Lys Gly Leu Val Ser Pro Gln Ser Pro Gln Lys
                325                 330                 335     
Ser Asp Cys Gln Pro Asn Ser Pro Thr Glu Ser Cys Ser Ser Lys Asn
            340                 345                 350         
Ala Cys Ile Leu Gln Ala Ser Gly Ser Pro Pro Ala Lys Ser Pro Thr
        355                 360                 365             
Asp Pro Lys Ala Cys Asn Trp Lys Lys Tyr Lys Phe Ile Val Leu Asn
    370                 375                 380                 
Ser Leu Asn Gln Asn Ala Lys Pro Glu Gly Pro Glu Gln Ala Glu Leu
385                 390                 395                 400 
Gly Arg Leu Ser Pro Arg Ala Tyr Thr Ala Pro Pro Ala Cys Gln Pro
                405                 410                 415     
Pro Met Glu Pro Glu Asn Leu Asp Leu Gln Ser Pro Thr Lys Leu Ser
            420                 425                 430         
Ala Ser Gly Glu Asp Ser Thr Ile Pro Gln Ala Ser Arg Leu Asn Asn
        435                 440                 445             
Ile Val Asn Arg Ser Met Thr Gly Ser Pro Arg Ser Ser Ser Glu Ser
    450                 455                 460                 
His Ser Pro Leu Tyr Met His Pro Pro Lys Cys Thr Ser Cys Gly Ser
465                 470                 475                 480 
Gln Ser Pro Gln His Ala Glu Met Cys Leu His Thr Ala Gly Pro Thr
                485                 490                 495     
Phe Pro Glu Glu Met Gly Glu Thr Gln Ser Glu Tyr Ser Asp Ser Ser
            500                 505                 510         
Cys Glu Asn Gly Ala Phe Phe Cys Asn Glu Cys Asp Cys Arg Phe Ser
        515                 520                 525             
Glu Glu Ala Ser Leu Lys Arg His Thr Leu Gln Thr His Ser Asp Lys
    530                 535                 540                 
Pro Tyr Lys Cys Asp Arg Cys Gln Ala Ser Phe Arg Tyr Lys Gly Asn
545                 550                 555                 560 
Leu Ala Ser His Lys Thr Val His Thr Gly Glu Lys Pro Tyr Arg Cys
                565                 570                 575     
Asn Ile Cys Gly Ala Gln Phe Asn Arg Pro Ala Asn Leu Lys Thr His
            580                 585                 590         
Thr Arg Ile His Ser Gly Glu Lys Pro Tyr Lys Cys Glu Thr Cys Gly
        595                 600                 605             
Ala Arg Phe Val Gln Val Ala His Leu Arg Ala His Val Leu Ile His
    610                 615                 620                 
Thr Gly Glu Lys Pro Tyr Pro Cys Glu Ile Cys Gly Thr Arg Phe Arg
625                 630                 635                 640 
His Leu Gln Thr Leu Lys Ser His Leu Arg Ile His Thr Gly Glu Lys
                645                 650                 655     
Pro Tyr His Cys Glu Lys Cys Arg Leu His Phe Arg His Lys Ser Gln
            660                 665                 670         
Leu Arg Leu His Leu Arg Gln Lys His Gly Ala Ile Thr Asn Thr Lys
        675                 680                 685             
Val Gln Tyr Arg Val Ser Ala Thr Asp Leu Pro Pro Glu Leu Pro Lys
    690                 695                 700                 
Ala Cys
705     


<210> 1989
<211> 442
<212> PRT
<213> Homo sapiens

<400> 1989
Met Tyr Gln Arg Met Leu Arg Cys Gly Ala Glu Leu Gly Ser Pro Gly
 1               5                  10                  15      
Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Gly Gly Arg Leu Ala
            20                  25                  30          
Leu Leu Trp Ile Val Pro Leu Thr Leu Ser Gly Leu Leu Gly Val Ala
        35                  40                  45              
Trp Gly Ala Ser Ser Leu Gly Ala His His Ile His His Phe His Gly
    50                  55                  60                  
Ser Ser Lys His His Ser Val Pro Ile Ala Ile Tyr Arg Ser Pro Ala
65                  70                  75                  80  
Ser Leu Arg Gly Gly His Ala Gly Thr Thr Tyr Ile Phe Ser Lys Gly
                85                  90                  95      
Gly Gly Gln Ile Thr Tyr Lys Trp Pro Pro Asn Asp Arg Pro Ser Thr
            100                 105                 110         
Arg Ala Asp Arg Leu Ala Ile Gly Phe Ser Thr Val Gln Lys Glu Ala
        115                 120                 125             
Val Leu Val Arg Val Asp Ser Ser Ser Gly Leu Gly Asp Tyr Leu Glu
    130                 135                 140                 
Leu His Ile His Gln Gly Lys Ile Gly Val Lys Phe Asn Val Gly Thr
145                 150                 155                 160 
Asp Asp Ile Ala Ile Glu Glu Ser Asn Ala Ile Ile Asn Asp Gly Lys
                165                 170                 175     
Tyr His Val Val Arg Phe Thr Arg Ser Gly Gly Asn Ala Thr Leu Gln
            180                 185                 190         
Val Asp Ser Trp Pro Val Ile Glu Arg Tyr Pro Ala Gly Arg Gln Leu
        195                 200                 205             
Thr Ile Phe Asn Ser Gln Ala Thr Ile Ile Ile Gly Gly Lys Glu Gln
    210                 215                 220                 
Gly Gln Pro Phe Gln Gly Gln Leu Ser Gly Leu Tyr Tyr Asn Gly Leu
225                 230                 235                 240 
Lys Val Leu Asn Met Ala Ala Glu Asn Asp Ala Asn Ile Ala Ile Val
                245                 250                 255     
Gly Asn Val Arg Leu Val Gly Glu Val Pro Ser Ser Met Thr Thr Glu
            260                 265                 270         
Ser Thr Ala Thr Ala Met Gln Ser Glu Met Ser Thr Ser Ile Met Glu
        275                 280                 285             
Thr Thr Thr Thr Leu Ala Thr Ser Thr Ala Arg Arg Gly Lys Pro Pro
    290                 295                 300                 
Thr Lys Glu Pro Ile Ser Gln Thr Thr Asp Asp Ile Leu Val Ala Ser
305                 310                 315                 320 
Ala Glu Cys Pro Ser Asp Asp Glu Asp Ile Asp Pro Cys Glu Pro Ser
                325                 330                 335     
Ser Gly Gly Leu Ala Asn Pro Thr Arg Ala Gly Gly Arg Glu Pro Tyr
            340                 345                 350         
Pro Gly Ser Ala Glu Val Ile Arg Glu Ser Ser Ser Thr Thr Gly Met
        355                 360                 365             
Val Val Gly Ile Val Ala Ala Ala Ala Leu Cys Ile Leu Ile Leu Leu
    370                 375                 380                 
Tyr Ala Met Tyr Lys Tyr Arg Asn Arg Asp Glu Gly Ser Tyr His Val
385                 390                 395                 400 
Asp Glu Ser Arg Asn Tyr Ile Ser Asn Ser Ala Gln Ser Asn Gly Ala
                405                 410                 415     
Val Val Lys Glu Lys Gln Pro Ser Ser Ala Lys Ser Ser Asn Lys Asn
            420                 425                 430         
Lys Lys Asn Lys Asp Lys Glu Tyr Tyr Val
        435                 440         


<210> 1990
<211> 462
<212> PRT
<213> Homo sapiens

<400> 1990
Met Gln Leu Arg Lys Met Gln Thr Val Lys Lys Glu Gln Ala Ser Leu
 1               5                  10                  15      
Asp Ala Ser Ser Asn Val Asp Lys Met Met Val Leu Asn Ser Ala Leu
            20                  25                  30          
Thr Glu Val Ser Glu Asp Ser Thr Thr Gly Glu Glu Leu Leu Leu Ser
        35                  40                  45              
Glu Gly Ser Val Gly Lys Asn Lys Ser Ser Ala Cys Arg Arg Lys Arg
    50                  55                  60                  
Glu Phe Ile Pro Asp Glu Lys Lys Asp Ala Met Tyr Trp Glu Lys Arg
65                  70                  75                  80  
Arg Lys Asn Asn Glu Ala Ala Lys Arg Ser Arg Glu Lys Arg Arg Leu
                85                  90                  95      
Asn Asp Leu Val Leu Glu Asn Lys Leu Ile Ala Leu Gly Glu Glu Asn
            100                 105                 110         
Ala Thr Leu Lys Ala Glu Leu Leu Ser Leu Lys Leu Lys Phe Gly Leu
        115                 120                 125             
Ile Ser Ser Thr Ala Tyr Ala Gln Glu Ile Gln Lys Leu Ser Asn Ser
    130                 135                 140                 
Thr Ala Val Tyr Phe Gln Asp Tyr Gln Thr Ser Lys Ser Asn Val Ser
145                 150                 155                 160 
Ser Phe Val Asp Glu His Glu Pro Ser Met Val Ser Ser Ser Cys Ile
                165                 170                 175     
Ser Val Ile Lys His Ser Pro Gln Ser Ser Leu Ser Asp Val Ser Glu
            180                 185                 190         
Val Ser Ser Val Glu His Thr Gln Glu Ser Ser Val Gln Gly Ser Cys
        195                 200                 205             
Arg Ser Pro Glu Asn Lys Phe Gln Ile Ile Lys Gln Glu Pro Met Glu
    210                 215                 220                 
Leu Glu Ser Tyr Thr Arg Glu Pro Arg Asp Asp Arg Gly Ser Tyr Thr
225                 230                 235                 240 
Ala Ser Ile Tyr Gln Asn Tyr Met Gly Asn Ser Phe Ser Gly Tyr Ser
                245                 250                 255     
His Ser Pro Pro Leu Leu Gln Val Asn Arg Ser Ser Ser Asn Ser Pro
            260                 265                 270         
Arg Thr Ser Glu Thr Asp Asp Gly Val Val Gly Lys Ser Ser Asp Gly
        275                 280                 285             
Glu Asp Glu Gln Gln Val Pro Lys Gly Pro Ile His Ser Pro Val Glu
    290                 295                 300                 
Leu Lys His Val His Ala Thr Val Val Lys Val Pro Glu Val Asn Ser
305                 310                 315                 320 
Ser Ala Leu Pro His Lys Leu Arg Ile Lys Ala Lys Ala Met Gln Ile
                325                 330                 335     
Lys Val Glu Ala Phe Asp Asn Glu Phe Glu Ala Thr Gln Lys Leu Ser
            340                 345                 350         
Ser Pro Ile Asp Met Thr Ser Lys Arg His Phe Glu Leu Glu Lys His
        355                 360                 365             
Ser Ala Pro Ser Met Val His Ser Ser Leu Thr Pro Phe Ser Val Gln
    370                 375                 380                 
Val Thr Asn Ile Gln Asp Trp Ser Leu Lys Ser Glu His Trp His Gln
385                 390                 395                 400 
Lys Glu Leu Ser Gly Lys Thr Gln Asn Ser Phe Lys Thr Gly Val Val
                405                 410                 415     
Glu Met Lys Asp Ser Gly Tyr Lys Val Ser Asp Pro Glu Asn Leu Tyr
            420                 425                 430         
Leu Lys Gln Gly Ile Ala Asn Leu Ser Ala Glu Val Val Ser Leu Lys
        435                 440                 445             
Arg Leu Ile Ala Thr Gln Pro Ile Ser Ala Ser Asp Ser Gly
    450                 455                 460         


<210> 1991
<211> 124
<212> PRT
<213> Homo sapiens

<400> 1991
Met Phe Cys Val Cys Val Trp Cys Ala Pro Ser Ser His Cys Leu Asn
 1               5                  10                  15      
Ser Leu Lys Ser Pro His Val Ser Pro Thr Gly Ser Pro Gln Thr Thr
            20                  25                  30          
Ser Glu Gly Leu Thr Cys Cys His Ser Leu Leu Leu Pro Gln Ser Arg
        35                  40                  45              
Val Met Arg Met Asp Gly Val Gln Gly Phe Arg Trp Gly Leu Arg Arg
    50                  55                  60                  
Cys Pro Cys Trp Pro Cys Pro Ser Trp Leu Ser Arg Pro Gly Phe Thr
65                  70                  75                  80  
Val Gln Leu His Leu Tyr Ala Gly Arg Gly Ala Asp Ser Ser Gly Thr
                85                  90                  95      
Pro Trp Phe Trp Ile Pro Phe Leu Gly Ser Leu Trp Arg Gln Pro Gly
            100                 105                 110         
Phe Ser Gly Ala Ala Ser Gln Gln Leu Ser Gln Gly
        115                 120                 


<210> 1992
<211> 1417
<212> PRT
<213> Homo sapiens

<400> 1992
Met Gly Ala Met Glu Ile Asn Arg Asn Ile Arg Phe Ala Thr Tyr Thr
 1               5                  10                  15      
Lys Glu Asn Gly Arg Thr Leu Val Val Gln Asp Glu Pro Val Gly Gly
            20                  25                  30          
Asp Thr Pro Ala Ser Phe Thr Pro Tyr Ser Thr Ala Thr Gly Gln Thr
        35                  40                  45              
Pro Leu Ala Pro Glu Val Gly Gly Ala Glu Asn Lys Glu Ala Gly Lys
    50                  55                  60                  
Thr Leu Glu Gln Val Gly Gln Gly Ile Val Ala Ser Ala Ala Val Val
65                  70                  75                  80  
Thr Thr Ala Ser Ser Thr Pro Asn Thr Val Arg Ile Ser Asp Thr Gly
                85                  90                  95      
Leu Ala Ala Gly Thr Val Pro Glu Lys Gln Lys Gly Ser Arg Ser Gln
            100                 105                 110         
Ala Ser Gly Glu Asn Ser Arg Asn Ser Ile Leu Ala Ser Ser Gly Phe
        115                 120                 125             
Gly Ala Pro Leu Pro Ser Ser Ser Gln Pro Leu Thr Phe Gly Ser Gly
    130                 135                 140                 
Arg Ser Gln Ser Asn Gly Val Leu Ala Thr Glu Asn Lys Pro Leu Gly
145                 150                 155                 160 
Phe Ser Phe Gly Cys Ser Ser Ala Gln Glu Ala Gln Lys Asp Thr Asp
                165                 170                 175     
Leu Ser Lys Asn Leu Phe Phe Gln Cys Met Ser Gln Thr Leu Pro Thr
            180                 185                 190         
Ser Asn Tyr Phe Thr Thr Val Ser Glu Ser Leu Ala Asp Asp Ser Ser
        195                 200                 205             
Ser Arg Asp Ser Phe Lys Gln Ser Leu Glu Ser Leu Ser Ser Gly Leu
    210                 215                 220                 
Cys Lys Gly Arg Ser Val Leu Gly Thr Asp Thr Lys Pro Gly Ser Lys
225                 230                 235                 240 
Ala Gly Ser Ser Val Asp Arg Lys Val Pro Ala Glu Ser Met Pro Thr
                245                 250                 255     
Leu Thr Pro Ala Phe Pro Arg Ser Leu Leu Asn Ala Arg Thr Pro Glu
            260                 265                 270         
Asn His Glu Asn Leu Phe Leu Gln Pro Pro Lys Leu Ser Arg Glu Glu
        275                 280                 285             
Pro Ser Asn Pro Phe Leu Ala Phe Val Glu Lys Val Glu His Ser Pro
    290                 295                 300                 
Phe Ser Ser Phe Ala Ser Gln Ala Ser Gly Ser Ser Ser Ser Ala Thr
305                 310                 315                 320 
Thr Val Thr Ser Lys Val Ala Pro Ser Trp Pro Glu Ser His Ser Ser
                325                 330                 335     
Ala Asp Ser Ala Ser Leu Ala Lys Lys Lys Pro Leu Phe Ile Thr Thr
            340                 345                 350         
Asp Ser Ser Lys Leu Val Ser Gly Val Leu Gly Ser Ala Leu Thr Ser
        355                 360                 365             
Gly Gly Pro Ser Leu Ser Ala Met Gly Asn Gly Arg Ser Ser Ser Pro
    370                 375                 380                 
Thr Ser Ser Leu Thr Gln Pro Ile Glu Met Pro Thr Leu Ser Ser Ser
385                 390                 395                 400 
Pro Thr Glu Glu Arg Pro Thr Val Gly Pro Gly Gln Gln Asp Asn Pro
                405                 410                 415     
Leu Leu Lys Thr Phe Ser Asn Val Phe Gly Arg His Ser Gly Gly Phe
            420                 425                 430         
Leu Ser Ser Pro Ala Asp Phe Ser Gln Glu Asn Lys Ala Pro Phe Glu
        435                 440                 445             
Ala Val Lys Arg Phe Ser Leu Asp Glu Arg Ser Leu Ala Cys Arg Gln
    450                 455                 460                 
Asp Ser Asp Ser Ser Thr Asn Ser Asp Leu Ser Asp Leu Ser Asp Ser
465                 470                 475                 480 
Glu Glu Gln Leu Gln Ala Lys Thr Gly Leu Lys Gly Ile Pro Glu His
                485                 490                 495     
Leu Met Gly Lys Leu Gly Pro Asn Gly Glu Arg Ser Ala Glu Leu Leu
            500                 505                 510         
Leu Gly Lys Ser Lys Gly Lys Gln Ala Pro Lys Gly Arg Pro Arg Thr
        515                 520                 525             
Ala Pro Leu Lys Val Gly Gln Ser Val Leu Lys Asp Val Ser Lys Val
    530                 535                 540                 
Lys Lys Leu Lys Gln Ser Gly Glu Pro Phe Leu Gln Asp Gly Ser Cys
545                 550                 555                 560 
Ile Asn Val Ala Pro His Leu His Lys Cys Arg Glu Cys Arg Leu Glu
                565                 570                 575     
Arg Tyr Arg Lys Phe Lys Glu Gln Glu Gln Asp Asp Ser Thr Val Ala
            580                 585                 590         
Cys Arg Phe Phe His Phe Arg Arg Leu Ile Phe Thr Arg Lys Gly Val
        595                 600                 605             
Leu Arg Val Glu Gly Phe Leu Ser Pro Gln Gln Ser Asp Pro Asp Ala
    610                 615                 620                 
Met Asn Leu Trp Ile Pro Ser Ser Ser Leu Ala Glu Gly Ile Asp Leu
625                 630                 635                 640 
Glu Thr Ser Lys Tyr Ile Leu Ala Asn Val Gly Asp Gln Phe Cys Gln
                645                 650                 655     
Leu Val Met Ser Glu Lys Glu Ala Met Met Met Val Glu Pro His Gln
            660                 665                 670         
Lys Val Ala Trp Lys Arg Ala Val Arg Gly Val Arg Glu Met Cys Asp
        675                 680                 685             
Val Cys Glu Thr Thr Leu Phe Asn Ile His Trp Val Cys Arg Lys Cys
    690                 695                 700                 
Gly Phe Gly Val Cys Leu Asp Cys Tyr Arg Leu Arg Lys Ser Arg Pro
705                 710                 715                 720 
Arg Ser Glu Thr Glu Glu Met Gly Asp Glu Glu Val Phe Ser Trp Leu
                725                 730                 735     
Lys Cys Ala Lys Gly Gln Ser His Glu Pro Glu Asn Leu Met Pro Thr
            740                 745                 750         
Gln Ile Ile Pro Gly Thr Ala Leu Tyr Asn Ile Gly Asp Met Val His
        755                 760                 765             
Ala Ala Arg Gly Lys Trp Gly Ile Lys Ala Asn Cys Pro Cys Ile Ser
    770                 775                 780                 
Arg Gln Asn Lys Ser Val Leu Arg Pro Ala Val Thr Asn Gly Met Ser
785                 790                 795                 800 
Gln Leu Pro Ser Ile Asn Pro Ser Ala Ser Ser Gly Asn Glu Thr Thr
                805                 810                 815     
Phe Ser Gly Gly Gly Gly Pro Ala Pro Val Thr Thr Pro Glu Pro Asp
            820                 825                 830         
His Val Pro Lys Ala Asp Ser Thr Asp Ile Arg Ser Glu Glu Pro Leu
        835                 840                 845             
Lys Thr Asp Ser Ser Ala Ser Asn Ser Asn Ser Glu Leu Lys Ala Ile
    850                 855                 860                 
Arg Pro Pro Cys Pro Asp Thr Ala Pro Pro Ser Ser Ala Leu His Trp
865                 870                 875                 880 
Leu Ala Asp Leu Ala Thr Gln Lys Ala Lys Glu Glu Thr Lys Glu Ala
                885                 890                 895     
Gly Ser Leu Arg Ser Val Leu Asn Lys Glu Ser His Ser Pro Phe Gly
            900                 905                 910         
Leu Asp Ser Phe Asn Ser Thr Ala Lys Val Ser Pro Leu Thr Pro Lys
        915                 920                 925             
Leu Phe Asn Ser Leu Leu Leu Gly Pro Thr Ala Ser Asn Asn Lys Thr
    930                 935                 940                 
Glu Gly Ser Ser Leu Arg Asp Leu Leu His Ser Gly Pro Gly Lys Leu
945                 950                 955                 960 
Pro Gln Thr Pro Leu Asp Thr Gly Ile Pro Phe Pro Pro Val Phe Ser
                965                 970                 975     
Thr Ser Ser Ala Gly Val Lys Ser Lys Ala Ser Leu Pro Asn Phe Leu
            980                 985                 990         
Asp His Ile Ile Ala Ser Val Val Glu Asn Lys Lys Thr Ser Asp Ala
        995                 1000                1005            
Ser Lys Arg Ala Cys Asn Leu Thr Asp Thr Gln Lys Glu Val Lys Glu
    1010                1015                1020                
Met Val Met Gly Leu Asn Val Leu Asp Pro His Thr Ser His Ser Trp
1025                1030                1035                1040
Leu Cys Asp Gly Arg Leu Leu Cys Leu His Asp Pro Ser Asn Lys Asn
                1045                1050                1055    
Asn Trp Lys Ile Phe Arg Glu Cys Trp Lys Gln Gly Gln Pro Val Leu
            1060                1065                1070        
Val Ser Gly Val His Lys Lys Leu Lys Ser Glu Leu Trp Lys Pro Glu
        1075                1080                1085            
Ala Phe Ser Gln Glu Phe Gly Asp Gln Asp Val Asp Leu Val Asn Cys
    1090                1095                1100                
Arg Asn Cys Ala Ile Ile Ser Asp Val Lys Val Arg Asp Phe Trp Asp
1105                1110                1115                1120
Gly Phe Glu Ile Ile Cys Lys Arg Leu Arg Ser Glu Asp Gly Gln Pro
                1125                1130                1135    
Met Val Leu Lys Leu Lys Asp Trp Pro Pro Gly Glu Asp Phe Arg Asp
            1140                1145                1150        
Met Met Pro Thr Arg Phe Glu Asp Leu Met Glu Asn Leu Pro Leu Pro
        1155                1160                1165            
Glu Tyr Thr Lys Arg Asp Gly Arg Leu Asn Leu Ala Ser Arg Leu Pro
    1170                1175                1180                
Ser Tyr Phe Val Arg Pro Asp Leu Gly Pro Lys Met Tyr Asn Ala Tyr
1185                1190                1195                1200
Gly Leu Ile Thr Ala Glu Asp Arg Arg Val Gly Thr Thr Asn Leu His
                1205                1210                1215    
Leu Asp Val Ser Asp Ala Val Asn Val Met Val Tyr Val Gly Ile Pro
            1220                1225                1230        
Ile Gly Glu Gly Ala His Asp Glu Glu Val Leu Lys Thr Ile Asp Glu
        1235                1240                1245            
Gly Asp Ala Asp Glu Val Thr Lys Gln Arg Ile His Asp Gly Lys Glu
    1250                1255                1260                
Lys Pro Gly Ala Leu Trp His Ile Tyr Ala Ala Lys Asp Ala Glu Lys
1265                1270                1275                1280
Ile Arg Glu Leu Leu Arg Lys Val Gly Glu Glu Gln Gly Gln Glu Asn
                1285                1290                1295    
Pro Pro Asp His Asp Pro Ile His Asp Gln Ser Trp Tyr Leu Asp Gln
            1300                1305                1310        
Thr Leu Arg Lys Arg Leu Tyr Glu Glu Tyr Gly Val Gln Gly Trp Ala
        1315                1320                1325            
Ile Val Gln Phe Leu Gly Asp Ala Val Phe Ile Pro Ala Gly Ala Pro
    1330                1335                1340                
His Gln Val His Asn Leu Tyr Ser Cys Ile Lys Val Ala Glu Asp Phe
1345                1350                1355                1360
Val Ser Pro Glu His Val Lys His Cys Phe Arg Leu Thr Gln Glu Phe
                1365                1370                1375    
Arg His Leu Ser Asn Thr His Thr Asn His Glu Asp Lys Leu Gln Val
            1380                1385                1390        
Lys Asn Ile Ile Tyr His Ala Val Lys Asp Ala Val Gly Thr Leu Lys
        1395                1400                1405            
Ala His Glu Ser Lys Leu Ala Arg Ser
    1410                1415        


<210> 1993
<211> 305
<212> PRT
<213> Homo sapiens

<400> 1993
Met Gly Ile Gln Thr Ser Pro Val Leu Leu Ala Ser Leu Gly Val Gly
 1               5                  10                  15      
Leu Val Thr Leu Leu Gly Leu Ala Val Gly Ser Tyr Leu Val Arg Arg
            20                  25                  30          
Ser Arg Arg Pro Gln Val Thr Leu Leu Asp Pro Asn Glu Lys Tyr Leu
        35                  40                  45              
Leu Arg Leu Leu Asp Lys Thr Thr Val Ser His Asn Thr Lys Arg Phe
    50                  55                  60                  
Arg Phe Ala Leu Pro Thr Ala His His Thr Leu Gly Leu Pro Val Gly
65                  70                  75                  80  
Lys His Ile Tyr Leu Ser Thr Arg Ile Asp Gly Ser Leu Val Ile Arg
                85                  90                  95      
Pro Tyr Thr Pro Val Thr Ser Asp Glu Asp Gln Gly Tyr Val Asp Leu
            100                 105                 110         
Val Ile Lys Val Tyr Leu Lys Gly Val His Pro Lys Phe Pro Glu Gly
        115                 120                 125             
Gly Lys Met Ser Gln Tyr Leu Asp Ser Leu Lys Val Gly Asp Val Val
    130                 135                 140                 
Glu Phe Arg Gly Pro Ser Gly Leu Leu Thr Tyr Thr Gly Lys Gly His
145                 150                 155                 160 
Phe Asn Ile Gln Pro Asn Lys Lys Ser Pro Pro Glu Pro Arg Val Ala
                165                 170                 175     
Lys Lys Leu Gly Met Ile Ala Gly Gly Thr Gly Ile Thr Pro Met Leu
            180                 185                 190         
Gln Leu Ile Arg Ala Ile Leu Lys Val Pro Glu Asp Pro Thr Gln Cys
        195                 200                 205             
Phe Leu Leu Phe Ala Asn Gln Thr Glu Lys Asp Ile Ile Leu Arg Glu
    210                 215                 220                 
Asp Leu Glu Glu Leu Gln Ala Arg Tyr Pro Asn Arg Phe Lys Leu Trp
225                 230                 235                 240 
Phe Thr Leu Asp His Pro Pro Lys Asp Trp Ala Tyr Ser Lys Gly Phe
                245                 250                 255     
Val Thr Ala Asp Met Ile Arg Glu His Leu Pro Ala Pro Gly Asp Asp
            260                 265                 270         
Val Leu Val Leu Leu Cys Gly Pro Pro Pro Met Val Gln Leu Ala Cys
        275                 280                 285             
His Pro Asn Leu Asp Lys Leu Gly Tyr Ser Gln Lys Met Arg Phe Thr
    290                 295                 300                 
Tyr
305 


<210> 1994
<211> 480
<212> PRT
<213> Homo sapiens

<400> 1994
Met Ala Ala Ser Val Val Cys Arg Ala Ala Thr Ala Gly Ala Gln Val
 1               5                  10                  15      
Leu Leu Arg Ala Arg Arg Ser Pro Ala Leu Leu Arg Thr Pro Ala Leu
            20                  25                  30          
Arg Ser Thr Ala Thr Phe Ala Gln Ala Leu Gln Phe Val Pro Glu Thr
        35                  40                  45              
Gln Val Ser Leu Leu Asp Asn Gly Leu Arg Val Ala Ser Glu Gln Ser
    50                  55                  60                  
Ser Gln Pro Thr Cys Thr Val Gly Val Trp Ile Asp Val Gly Ser Arg
65                  70                  75                  80  
Phe Glu Thr Glu Lys Asn Asn Gly Ala Gly Tyr Phe Leu Glu His Leu
                85                  90                  95      
Ala Phe Lys Gly Thr Lys Asn Arg Pro Gly Ser Ala Leu Glu Lys Glu
            100                 105                 110         
Val Glu Ser Met Gly Ala His Leu Asn Ala Tyr Ser Thr Arg Glu His
        115                 120                 125             
Thr Ala Tyr Tyr Ile Lys Ala Leu Ser Lys Asp Leu Pro Lys Ala Val
    130                 135                 140                 
Glu Leu Leu Gly Asp Ile Val Gln Asn Cys Ser Leu Glu Asp Ser Gln
145                 150                 155                 160 
Ile Glu Lys Glu Arg Asp Val Ile Leu Arg Glu Met Gln Glu Asn Asp
                165                 170                 175     
Ala Ser Met Arg Asp Val Val Phe Asn Tyr Leu His Ala Thr Ala Phe
            180                 185                 190         
Gln Gly Thr Pro Leu Ala Gln Ala Val Glu Gly Pro Ser Glu Asn Val
        195                 200                 205             
Arg Lys Leu Ser Arg Ala Asp Leu Thr Glu Tyr Leu Ser Thr His Tyr
    210                 215                 220                 
Lys Ala Pro Arg Met Val Leu Ala Ala Ala Gly Gly Val Glu His Gln
225                 230                 235                 240 
Gln Leu Leu Asp Leu Ala Gln Lys His Leu Gly Gly Ile Pro Trp Thr
                245                 250                 255     
Tyr Ala Glu Asp Ala Val Pro Thr Leu Thr Pro Cys Arg Phe Thr Gly
            260                 265                 270         
Ser Glu Ile Arg His Arg Asp Asp Ala Leu Pro Phe Ala His Val Ala
        275                 280                 285             
Ile Ala Val Glu Gly Pro Gly Trp Ala Ser Pro Asp Asn Val Ala Leu
    290                 295                 300                 
Gln Val Ala Asn Ala Ile Ile Gly His Tyr Asp Cys Thr Tyr Gly Gly
305                 310                 315                 320 
Gly Val His Leu Ser Ser Pro Leu Ala Ser Gly Ala Val Ala Asn Lys
                325                 330                 335     
Leu Cys Gln Ser Phe Gln Thr Phe Ser Ile Cys Tyr Ala Glu Thr Gly
            340                 345                 350         
Leu Leu Gly Ala His Phe Val Cys Asp Arg Met Lys Ile Asp Asp Met
        355                 360                 365             
Met Phe Val Leu Gln Gly Gln Trp Met Arg Leu Cys Thr Ser Ala Thr
    370                 375                 380                 
Glu Ser Glu Val Ala Arg Gly Lys Asn Ile Leu Arg Asn Ala Leu Val
385                 390                 395                 400 
Ser His Leu Asp Gly Thr Thr Pro Val Cys Glu Asp Ile Gly Arg Ser
                405                 410                 415     
Leu Leu Thr Tyr Gly Arg Arg Ile Pro Leu Ala Glu Trp Glu Ser Arg
            420                 425                 430         
Ile Ala Glu Val Asp Ala Ser Val Val Arg Glu Ile Cys Ser Lys Tyr
        435                 440                 445             
Ile Tyr Asp Gln Cys Pro Ala Val Ala Gly Tyr Gly Pro Ile Glu Gln
    450                 455                 460                 
Leu Pro Asp Tyr Asn Arg Ile Arg Ser Gly Met Phe Trp Leu Arg Phe
465                 470                 475                 480 


<210> 1995
<211> 1302
<212> PRT
<213> Homo sapiens

<400> 1995
Met Lys Ala Glu Asp Tyr Asp Val Val Lys Val Ile Gly Arg Gly Ala
 1               5                  10                  15      
Phe Gly Glu Val Gln Leu Val Arg His Lys Ala Ser Gln Lys Val Tyr
            20                  25                  30          
Ala Met Lys Leu Leu Ser Lys Phe Glu Met Ile Lys Arg Ser Asp Ser
        35                  40                  45              
Ala Phe Phe Trp Glu Glu Arg Asp Ile Met Ala Phe Ala Asn Ser Pro
    50                  55                  60                  
Trp Val Val Gln Leu Phe Tyr Ala Phe Gln Asp Asp Arg Tyr Leu Tyr
65                  70                  75                  80  
Met Val Met Glu Tyr Met Pro Gly Gly Asp Leu Val Asn Leu Met Ser
                85                  90                  95      
Asn Tyr Asp Val Pro Glu Lys Trp Ala Lys Phe Tyr Thr Ala Glu Val
            100                 105                 110         
Val Leu Ala Leu Asp Ala Ile His Ser Met Gly Leu Ile His Arg Asp
        115                 120                 125             
Val Lys Pro Asp Asn Met Leu Leu Asp Lys His Gly His Leu Lys Leu
    130                 135                 140                 
Ala Asp Phe Gly Thr Cys Met Lys Met Asp Glu Thr Gly Met Val His
145                 150                 155                 160 
Cys Asp Thr Ala Val Gly Thr Pro Asp Tyr Ile Ser Pro Glu Val Leu
                165                 170                 175     
Lys Ser Gln Gly Gly Asp Gly Phe Tyr Gly Arg Glu Cys Asp Trp Trp
            180                 185                 190         
Ser Val Gly Val Phe Leu Tyr Glu Met Leu Val Gly Asp Thr Pro Phe
        195                 200                 205             
Tyr Ala Asp Ser Leu Val Gly Thr Tyr Ser Lys Ile Met Asp His Lys
    210                 215                 220                 
Asn Ser Leu Cys Phe Pro Glu Asp Ala Glu Ile Ser Lys His Ala Lys
225                 230                 235                 240 
Asn Leu Ile Cys Ala Phe Leu Thr Asp Arg Glu Val Arg Leu Gly Arg
                245                 250                 255     
Asn Gly Val Glu Glu Ile Arg Gln His Pro Phe Phe Lys Asn Asp Gln
            260                 265                 270         
Trp His Trp Asp Asn Ile Arg Glu Thr Ala Ala Pro Val Val Pro Glu
        275                 280                 285             
Leu Ser Ser Asp Ile Asp Ser Ser Asn Phe Asp Asp Ile Glu Asp Asp
    290                 295                 300                 
Lys Gly Asp Val Glu Thr Phe Pro Ile Pro Lys Ala Phe Val Gly Asn
305                 310                 315                 320 
Gln Leu Pro Phe Ile Gly Phe Thr Tyr Tyr Arg Glu Asn Leu Leu Leu
                325                 330                 335     
Ser Asp Ser Pro Ser Cys Arg Glu Thr Asp Ser Ile Gln Ser Arg Lys
            340                 345                 350         
Asn Glu Glu Ser Gln Glu Ile Gln Lys Lys Leu Tyr Thr Leu Glu Glu
        355                 360                 365             
His Leu Ser Asn Glu Met Gln Ala Lys Glu Glu Leu Glu Gln Lys Cys
    370                 375                 380                 
Lys Ser Val Asn Thr Arg Leu Glu Lys Thr Ala Lys Glu Leu Glu Glu
385                 390                 395                 400 
Glu Ile Thr Leu Arg Lys Ser Val Glu Ser Ala Leu Arg Gln Leu Glu
                405                 410                 415     
Arg Glu Lys Ala Leu Leu Gln His Lys Asn Ala Glu Tyr Gln Arg Lys
            420                 425                 430         
Ala Asp His Glu Ala Asp Lys Lys Arg Asn Leu Glu Asn Asp Val Asn
        435                 440                 445             
Ser Leu Lys Asp Gln Leu Glu Asp Leu Lys Lys Arg Asn Gln Asn Ser
    450                 455                 460                 
Gln Ile Ser Thr Glu Lys Val Asn Gln Leu Gln Arg Gln Leu Asp Glu
465                 470                 475                 480 
Thr Asn Ala Leu Leu Arg Thr Glu Ser Asp Thr Ala Ala Arg Leu Arg
                485                 490                 495     
Lys Thr Gln Ala Glu Ser Ser Lys Gln Ile Gln Gln Leu Glu Ser Asn
            500                 505                 510         
Asn Arg Asp Leu Gln Asp Lys Asn Cys Leu Leu Glu Thr Ala Lys Leu
        515                 520                 525             
Lys Leu Glu Lys Glu Phe Ile Asn Leu Gln Ser Ala Leu Glu Ser Glu
    530                 535                 540                 
Arg Arg Asp Arg Thr His Gly Ser Glu Ile Ile Asn Asp Leu Gln Gly
545                 550                 555                 560 
Arg Ile Cys Gly Leu Glu Glu Asp Leu Lys Asn Gly Lys Ile Leu Leu
                565                 570                 575     
Ala Lys Val Glu Leu Glu Lys Arg Gln Leu Gln Glu Arg Phe Thr Asp
            580                 585                 590         
Leu Glu Lys Glu Lys Ser Asn Met Glu Ile Asp Met Thr Tyr Gln Leu
        595                 600                 605             
Lys Val Ile Gln Gln Ser Leu Glu Gln Glu Glu Ala Glu His Lys Ala
    610                 615                 620                 
Thr Lys Ala Arg Leu Ala Asp Lys Asn Lys Ile Tyr Glu Ser Ile Glu
625                 630                 635                 640 
Glu Ala Lys Ser Glu Ala Met Lys Glu Met Glu Lys Lys Leu Leu Glu
                645                 650                 655     
Glu Arg Thr Leu Lys Gln Lys Val Glu Asn Leu Leu Leu Glu Ala Glu
            660                 665                 670         
Lys Arg Cys Ser Leu Leu Asp Cys Asp Leu Lys Gln Ser Gln Gln Lys
        675                 680                 685             
Ile Asn Glu Leu Leu Lys Gln Lys Asp Val Leu Asn Glu Asp Val Arg
    690                 695                 700                 
Asn Leu Thr Leu Lys Ile Glu Gln Glu Thr Gln Lys Arg Cys Leu Thr
705                 710                 715                 720 
Gln Asn Asp Leu Lys Met Gln Thr Gln Gln Val Asn Thr Leu Lys Met
                725                 730                 735     
Ser Glu Lys Gln Leu Lys Gln Glu Asn Asn His Leu Met Glu Met Lys
            740                 745                 750         
Met Asn Leu Glu Lys Gln Asn Ala Glu Leu Arg Lys Glu Arg Gln Asp
        755                 760                 765             
Ala Asp Gly Gln Met Lys Glu Leu Gln Asp Gln Leu Glu Ala Glu Gln
    770                 775                 780                 
Tyr Phe Ser Thr Leu Tyr Lys Thr Gln Val Arg Glu Leu Lys Glu Glu
785                 790                 795                 800 
Cys Glu Glu Lys Thr Lys Leu Gly Lys Glu Leu Gln Gln Lys Lys Gln
                805                 810                 815     
Glu Leu Gln Asp Glu Arg Asp Ser Leu Ala Ala Gln Leu Glu Ile Thr
            820                 825                 830         
Leu Thr Lys Ala Asp Ser Glu Gln Leu Ala Arg Ser Ile Ala Glu Glu
        835                 840                 845             
Gln Tyr Ser Asp Leu Glu Lys Glu Lys Ile Met Lys Glu Leu Glu Ile
    850                 855                 860                 
Lys Glu Met Met Ala Arg His Lys Gln Glu Leu Thr Glu Lys Asp Ala
865                 870                 875                 880 
Thr Ile Ala Ser Leu Glu Glu Thr Asn Arg Thr Leu Thr Ser Asp Val
                885                 890                 895     
Ala Asn Leu Ala Asn Glu Lys Glu Glu Leu Asn Asn Lys Leu Lys Asp
            900                 905                 910         
Val Gln Glu Gln Leu Ser Arg Leu Lys Asp Glu Glu Ile Ser Ala Ala
        915                 920                 925             
Ala Ile Lys Ala Gln Phe Glu Lys Gln Leu Leu Thr Glu Arg Thr Leu
    930                 935                 940                 
Lys Thr Gln Ala Val Asn Lys Leu Ala Glu Ile Met Asn Arg Lys Glu
945                 950                 955                 960 
Pro Val Lys Arg Gly Asn Asp Thr Asp Val Arg Arg Lys Glu Lys Glu
                965                 970                 975     
Asn Arg Lys Leu His Met Glu Leu Lys Ser Glu Arg Glu Lys Leu Thr
            980                 985                 990         
Gln Gln Met Ile Lys Tyr Gln Lys Glu Leu Asn Glu Met Gln Ala Gln
        995                 1000                1005            
Ile Ala Glu Glu Ser Gln Ile Arg Ile Glu Leu Gln Met Thr Leu Asp
    1010                1015                1020                
Ser Lys Asp Ser Asp Ile Glu Gln Leu Arg Ser Gln Leu Gln Ala Leu
1025                1030                1035                1040
His Ile Gly Leu Asp Ser Ser Ser Ile Gly Ser Gly Pro Gly Asp Ala
                1045                1050                1055    
Glu Ala Asp Asp Gly Phe Pro Glu Ser Arg Leu Glu Gly Trp Leu Ser
            1060                1065                1070        
Leu Pro Val Arg Asn Asn Thr Lys Lys Phe Gly Trp Val Lys Lys Tyr
        1075                1080                1085            
Val Ile Val Ser Ser Lys Lys Ile Leu Phe Tyr Asp Ser Glu Gln Asp
    1090                1095                1100                
Lys Glu Gln Ser Asn Pro Tyr Met Val Leu Asp Ile Asp Lys Leu Phe
1105                1110                1115                1120
His Val Arg Pro Val Thr Gln Thr Asp Val Tyr Arg Ala Asp Ala Lys
                1125                1130                1135    
Glu Ile Pro Arg Ile Phe Gln Ile Leu Tyr Ala Asn Glu Gly Glu Ser
            1140                1145                1150        
Lys Lys Glu Gln Glu Phe Pro Val Glu Pro Val Gly Glu Lys Ser Asn
        1155                1160                1165            
Tyr Ile Cys His Lys Gly His Glu Phe Ile Pro Thr Leu Tyr His Phe
    1170                1175                1180                
Pro Thr Asn Cys Glu Ala Cys Met Lys Pro Leu Trp His Met Phe Lys
1185                1190                1195                1200
Pro Pro Pro Ala Leu Glu Cys Arg Arg Cys His Ile Lys Cys His Lys
                1205                1210                1215    
Asp His Met Asp Lys Lys Glu Glu Ile Ile Ala Pro Cys Lys Val Tyr
            1220                1225                1230        
Tyr Asp Ile Ser Thr Ala Lys Asn Leu Leu Leu Leu Ala Asn Ser Thr
        1235                1240                1245            
Glu Glu Gln Gln Lys Trp Val Ser Arg Leu Val Lys Lys Ile Pro Lys
    1250                1255                1260                
Lys Pro Pro Ala Pro Asp Pro Phe Ala Arg Ser Ser Pro Arg Thr Ser
1265                1270                1275                1280
Met Lys Ile Gln Gln Asn Gln Ser Ile Arg Arg Pro Ser Arg Gln Leu
                1285                1290                1295    
Ala Pro Asn Lys Pro Ser
            1300        


<210> 1996
<211> 259
<212> PRT
<213> Homo sapiens

<400> 1996
Met Val Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Asn Leu Glu
 1               5                  10                  15      
Pro Glu Trp Ala Ala Ala Ala Ser Glu Val Lys Glu Gln Thr Lys Gly
            20                  25                  30          
Lys Val Lys Leu Ala Ala Val Asp Ala Thr Val Asn Gln Val Leu Ala
        35                  40                  45              
Ser Arg Tyr Gly Ile Arg Gly Phe Pro Thr Ile Lys Ile Phe Gln Lys
    50                  55                  60                  
Gly Glu Ser Pro Val Asp Tyr Asp Gly Gly Arg Thr Arg Ser Asp Ile
65                  70                  75                  80  
Val Ser Arg Ala Leu Asp Leu Phe Ser Asp Asn Ala Pro Pro Pro Glu
                85                  90                  95      
Leu Leu Glu Ile Ile Asn Glu Asp Ile Ala Lys Arg Thr Cys Glu Glu
            100                 105                 110         
His Gln Leu Cys Val Val Ala Val Leu Pro His Ile Leu Asp Thr Gly
        115                 120                 125             
Ala Ala Gly Arg Asn Ser Tyr Leu Glu Val Leu Leu Lys Leu Ala Asp
    130                 135                 140                 
Lys Tyr Lys Lys Lys Met Trp Gly Trp Leu Trp Thr Glu Ala Gly Ala
145                 150                 155                 160 
Gln Ser Glu Leu Glu Thr Ala Leu Gly Ile Gly Gly Phe Gly Tyr Pro
                165                 170                 175     
Ala Met Ala Ala Ile Asn Ala Arg Lys Met Lys Phe Ala Leu Leu Lys
            180                 185                 190         
Gly Ser Phe Ser Glu Gln Gly Ile Asn Glu Phe Leu Arg Glu Leu Ser
        195                 200                 205             
Phe Gly Arg Gly Ser Thr Ala Pro Val Gly Gly Gly Ala Phe Pro Thr
    210                 215                 220                 
Ile Val Glu Arg Glu Pro Trp Asp Gly Arg Asp Gly Glu Leu Pro Val
225                 230                 235                 240 
Glu Asp Asp Ile Asp Leu Ser Asp Val Glu Leu Asp Asp Leu Gly Lys
                245                 250                 255     
Asp Glu Leu
            


<210> 1997
<211> 824
<212> PRT
<213> Homo sapiens

<400> 1997
Met Glu Ser Ser Thr Leu Gln Glu Ser Pro Arg Ala Arg Ala Glu Ala
 1               5                  10                  15      
Val Leu Leu His Glu Met Asp Glu Asp Asp Leu Ala Asn Ala Leu Ile
            20                  25                  30          
Trp Pro Glu Ile Gln Gln Glu Leu Lys Ile Ile Glu Ser Glu Glu Glu
        35                  40                  45              
Leu Ser Ser Leu Pro Pro Pro Ala Leu Lys Thr Ser Pro Ile Gln Pro
    50                  55                  60                  
Ile Leu Glu Ser Ser Leu Gly Pro Phe Ile Pro Ser Glu Pro Pro Gly
65                  70                  75                  80  
Ser Leu Pro Cys Gly Ser Phe Pro Ala Pro Val Ser Thr Pro Leu Glu
                85                  90                  95      
Val Trp Thr Arg Asp Pro Ala Asn Gln Ser Thr Gln Gly Ala Ser Thr
            100                 105                 110         
Ala Ala Ser Arg Glu Lys Pro Glu Pro Glu Gln Gly Leu His Pro Asp
        115                 120                 125             
Leu Ala Ser Leu Ala Pro Leu Glu Ile Val Pro Phe Glu Lys Ala Ser
    130                 135                 140                 
Pro Gln Ala Thr Val Glu Val Gly Gly Pro Gly Asn Leu Ser Pro Pro
145                 150                 155                 160 
Leu Pro Pro Ala Pro Pro Pro Pro Thr Pro Leu Glu Glu Ser Thr Pro
                165                 170                 175     
Val Leu Leu Ser Lys Gly Gly Pro Glu Arg Glu Asp Ser Ser Arg Lys
            180                 185                 190         
Leu Arg Thr Asp Leu Tyr Ile Asp Gln Leu Lys Ser Gln Asp Ser Pro
        195                 200                 205             
Glu Ile Ser Ser Leu Cys Gln Gly Glu Glu Ala Thr Pro Arg His Ser
    210                 215                 220                 
Asp Lys Gln Asn Ser Lys Asn Ala Ala Ser Glu Gly Lys Gly Cys Gly
225                 230                 235                 240 
Phe Pro Ser Pro Thr Arg Glu Val Glu Ile Val Ser Gln Glu Glu Glu
                245                 250                 255     
Asp Val Thr His Ser Val Gln Glu Pro Ser Asp Cys Asp Glu Asp Asp
            260                 265                 270         
Thr Val Thr Asp Ile Ala Gln His Gly Leu Glu Met Val Glu Pro Trp
        275                 280                 285             
Glu Glu Pro Gln Trp Val Thr Ser Pro Leu His Ser Pro Thr Leu Lys
    290                 295                 300                 
Asp Ala His Lys Ala Gln Val Gln Gly Leu Gln Gly His Gln Leu Glu
305                 310                 315                 320 
Lys Arg Leu Ser His Arg Pro Ser Leu Arg Gln Ser His Ser Leu Asp
                325                 330                 335     
Ser Lys Pro Thr Val Lys Ser Gln Trp Thr Leu Glu Val Pro Ser Ser
            340                 345                 350         
Ser Ser Cys Ala Asn Leu Glu Thr Glu Arg Asn Ser Asp Pro Leu Gln
        355                 360                 365             
Pro Gln Ala Pro Arg Arg Glu Ile Thr Gly Trp Asp Glu Lys Ala Leu
    370                 375                 380                 
Arg Ser Phe Arg Glu Phe Ser Gly Leu Lys Gly Ala Glu Ala Pro Pro
385                 390                 395                 400 
Asn Gln Lys Gly Pro Ser Gly Val Gln Pro Asn Pro Ala Glu Thr Ser
                405                 410                 415     
Pro Ile Ser Leu Ala Glu Gly Lys Glu Leu Gly Thr His Leu Gly His
            420                 425                 430         
Ser Ser Pro Gln Ile Arg Gln Gly Gly Val Pro Gly Pro Glu Ser Ser
        435                 440                 445             
Lys Glu Ser Ser Pro Ser Val Gln Asp Ser Thr Ser Pro Gly Glu His
    450                 455                 460                 
Pro Ala Lys Leu Gln Leu Lys Ser Thr Glu Cys Gly Pro Pro Lys Gly
465                 470                 475                 480 
Lys Asn Arg Pro Ser Ser Leu Asn Leu Asp Pro Ala Ile Pro Ile Ala
                485                 490                 495     
Asp Leu Phe Trp Phe Glu Asn Val Ala Ser Phe Ser Ser Pro Gly Met
            500                 505                 510         
Gln Val Ser Glu Pro Gly Asp Pro Lys Val Thr Trp Met Thr Ser Ser
        515                 520                 525             
Tyr Cys Lys Ala Asp Pro Trp Arg Val Tyr Ser Gln Asp Pro Gln Asp
    530                 535                 540                 
Leu Asp Ile Val Ala His Ala Leu Thr Gly Arg Arg Asn Ser Ala Pro
545                 550                 555                 560 
Val Ser Val Ser Ala Val Arg Thr Ser Phe Met Val Lys Met Cys Gln
                565                 570                 575     
Ala Arg Ala Val Pro Val Ile Pro Pro Lys Ile Gln Tyr Thr Gln Ile
            580                 585                 590         
Pro Gln Pro Leu Pro Ser Gln Ser Ser Gly Glu Asn Gly Val Gln Pro
        595                 600                 605             
Leu Glu Arg Ser Gln Glu Gly Pro Ser Ser Thr Ser Gly Thr Thr Gln
    610                 615                 620                 
Lys Pro Ala Lys Asp Asp Ser Pro Ser Ser Leu Glu Ser Ser Lys Glu
625                 630                 635                 640 
Glu Lys Pro Lys Gln Asp Pro Gly Ala Ile Lys Ser Ser Pro Val Asp
                645                 650                 655     
Ala Thr Ala Pro Cys Met Cys Glu Gly Pro Thr Leu Ser Pro Glu Pro
            660                 665                 670         
Gly Ser Ser Asn Leu Leu Ser Thr Gln Asp Ala Val Val Gln Cys Arg
        675                 680                 685             
Lys Arg Met Ser Glu Thr Glu Pro Ser Gly Asp Asn Leu Leu Ser Ser
    690                 695                 700                 
Lys Leu Glu Arg Pro Ser Gly Gly Ser Lys Pro Phe His Arg Ser Arg
705                 710                 715                 720 
Pro Gly Arg Pro Gln Ser Leu Ile Leu Phe Ser Pro Pro Phe Pro Ile
                725                 730                 735     
Met Asp His Leu Pro Pro Ser Ser Thr Val Thr Asp Ser Lys Val Leu
            740                 745                 750         
Leu Ser Pro Ile Arg Ser Pro Thr Gln Thr Val Ser Pro Gly Leu Leu
        755                 760                 765             
Cys Gly Glu Leu Ala Glu Asn Thr Trp Val Thr Pro Glu Gly Val Thr
    770                 775                 780                 
Leu Arg Asn Lys Met Thr Ile Pro Lys Asn Gly Gln Arg Leu Glu Thr
785                 790                 795                 800 
Ser Thr Ser Cys Phe Tyr Gln Pro Gln Arg Arg Ser Val Ile Leu Asp
                805                 810                 815     
Gly Arg Ser Gly Arg Gln Ile Glu
            820                 


<210> 1998
<211> 489
<212> PRT
<213> Homo sapiens

<400> 1998
Met Lys Lys His Ile Pro Ser Ala Lys Asn Leu Asp Ala Asp Ile Trp
 1               5                  10                  15      
Lys Lys Phe Leu Ser Arg Pro Ala Leu Pro Phe Ile Leu Arg Leu Leu
            20                  25                  30          
Arg Gly Leu Ala Ile Gln His Pro Gly Thr Gln Val Leu Ile Gly Thr
        35                  40                  45              
Asp Ser Ile Pro Asn Leu His Lys Leu Glu Gln Val Ser Ser Asp Glu
    50                  55                  60                  
Gly Ile Gly Thr Leu Ala Glu Asn Leu Leu Glu Ala Leu Arg Glu His
65                  70                  75                  80  
Pro Asp Val Asn Lys Lys Ile Asp Ala Ala Arg Arg Glu Thr Arg Ala
                85                  90                  95      
Glu Lys Lys Arg Met Ala Met Ala Met Arg Gln Lys Ala Leu Gly Thr
            100                 105                 110         
Leu Gly Met Thr Thr Asn Glu Lys Gly Gln Val Val Thr Lys Thr Ala
        115                 120                 125             
Leu Leu Lys Gln Met Glu Glu Leu Ile Glu Glu Pro Gly Leu Thr Cys
    130                 135                 140                 
Cys Ile Cys Arg Glu Gly Tyr Lys Phe Gln Pro Thr Lys Val Leu Gly
145                 150                 155                 160 
Ile Tyr Thr Phe Thr Lys Arg Val Ala Leu Glu Glu Met Glu Asn Lys
                165                 170                 175     
Pro Arg Lys Gln Gln Gly Tyr Ser Thr Val Ser His Phe Asn Ile Val
            180                 185                 190         
His Tyr Asp Cys His Leu Ala Ala Val Arg Leu Ala Arg Gly Arg Glu
        195                 200                 205             
Glu Trp Glu Ser Ala Ala Leu Gln Asn Ala Asn Thr Lys Cys Asn Gly
    210                 215                 220                 
Leu Leu Pro Val Trp Gly Pro His Val Pro Glu Ser Ala Phe Ala Thr
225                 230                 235                 240 
Cys Leu Ala Arg His Asn Thr Tyr Leu Gln Glu Cys Thr Gly Gln Arg
                245                 250                 255     
Glu Pro Thr Tyr Gln Leu Asn Ile His Asp Ile Lys Leu Leu Phe Leu
            260                 265                 270         
Arg Phe Ala Met Glu Gln Ser Phe Ser Ala Asp Thr Gly Gly Gly Gly
        275                 280                 285             
Arg Glu Ser Asn Ile His Leu Ile Pro Tyr Ile Ile His Thr Val Leu
    290                 295                 300                 
Tyr Val Leu Asn Thr Thr Arg Ala Thr Ser Arg Glu Glu Lys Asn Leu
305                 310                 315                 320 
Gln Gly Phe Leu Glu Gln Pro Lys Glu Lys Trp Val Glu Ser Ala Phe
                325                 330                 335     
Glu Val Asp Gly Pro Tyr Tyr Phe Thr Val Leu Ala Leu His Ile Leu
            340                 345                 350         
Pro Pro Glu Gln Trp Arg Ala Thr Arg Val Glu Ile Leu Arg Arg Leu
        355                 360                 365             
Leu Val Thr Ser Gln Ala Arg Ala Val Ala Pro Gly Gly Ala Thr Arg
    370                 375                 380                 
Leu Thr Asp Lys Ala Val Lys Asp Tyr Ser Ala Tyr Arg Ser Ser Leu
385                 390                 395                 400 
Leu Phe Trp Ala Leu Val Asp Leu Ile Tyr Asn Met Phe Lys Lys Val
                405                 410                 415     
Pro Thr Ser Asn Thr Glu Gly Gly Trp Ser Cys Ser Leu Ala Glu Tyr
            420                 425                 430         
Ile Arg His Asn Asp Met Pro Ile Tyr Glu Ala Ala Asp Lys Ala Leu
        435                 440                 445             
Lys Thr Phe Gln Glu Glu Phe Met Pro Val Glu Thr Phe Ser Glu Phe
    450                 455                 460                 
Leu Asp Val Ala Gly Leu Leu Ser Glu Ile Thr Asp Pro Glu Ser Phe
465                 470                 475                 480 
Leu Lys Asp Leu Leu Asn Ser Val Pro
                485                 


<210> 1999
<211> 904
<212> PRT
<213> Homo sapiens

<400> 1999
Met Leu Leu His Gly Gln Asp Val Ile Thr Val Ser Asn Gly Gly Arg
 1               5                  10                  15      
Ile Met Arg Ser Trp Glu Thr Asn Ile Gly Gly Leu Asn Trp Glu Ile
            20                  25                  30          
Thr Leu Asp Ser Gly Ser Phe Gln Ala Leu Gly Leu Val Gly Leu Gln
        35                  40                  45              
Glu Ser Val Arg Tyr Ile Ala Val Leu Lys Lys Thr Thr Leu Ala Leu
    50                  55                  60                  
His His Leu Ser Ser Gly His Leu Lys Trp Val Glu His Leu Pro Glu
65                  70                  75                  80  
Ser Asp Ser Ile His Tyr Gln Met Val Tyr Ser Tyr Gly Ser Gly Val
                85                  90                  95      
Val Trp Ala Leu Gly Val Val Pro Phe Ser His Val Asn Ile Val Lys
            100                 105                 110         
Phe Asn Val Glu Asp Gly Glu Ile Val Gln Gln Val Arg Val Ser Thr
        115                 120                 125             
Pro Trp Leu Gln His Leu Ser Gly Ala Cys Gly Val Val Asp Glu Ala
    130                 135                 140                 
Val Leu Val Cys Pro Asp Pro Ser Ser Arg Ser Leu Gln Thr Leu Ala
145                 150                 155                 160 
Leu Glu Thr Glu Trp Glu Leu Arg Gln Ile Pro Leu Gln Ser Leu Asp
                165                 170                 175     
Leu Glu Phe Gly Ser Gly Phe Gln Pro Arg Val Leu Pro Thr Gln Pro
            180                 185                 190         
Asn Pro Val Asp Ala Ser Arg Ala Gln Phe Phe Leu His Leu Ser Pro
        195                 200                 205             
Ser His Tyr Ala Leu Leu Gln Tyr His Tyr Gly Thr Leu Ser Leu Leu
    210                 215                 220                 
Lys Asn Phe Pro Gln Thr Ala Leu Val Ser Phe Ala Thr Thr Gly Glu
225                 230                 235                 240 
Lys Thr Val Ala Ala Val Met Ala Cys Arg Asn Glu Val Gln Lys Ser
                245                 250                 255     
Ser Ser Ser Glu Asp Gly Ser Met Gly Ser Phe Ser Glu Lys Ser Ser
            260                 265                 270         
Ser Lys Asp Ser Leu Ala Cys Phe Asn Gln Thr Tyr Thr Ile Asn Leu
        275                 280                 285             
Tyr Leu Val Glu Thr Gly Arg Arg Leu Leu Asp Thr Thr Ile Thr Phe
    290                 295                 300                 
Ser Leu Glu Gln Ser Gly Thr Arg Pro Glu Arg Leu Tyr Ile Gln Val
305                 310                 315                 320 
Phe Leu Lys Lys Asp Asp Ser Val Gly Tyr Arg Ala Leu Val Gln Thr
                325                 330                 335     
Glu Asp His Leu Leu Leu Phe Leu Gln Gln Leu Ala Gly Lys Val Val
            340                 345                 350         
Leu Trp Ser Arg Glu Glu Ser Leu Ala Glu Val Val Cys Leu Glu Met
        355                 360                 365             
Val Asp Leu Pro Leu Thr Gly Ala Gln Ala Glu Leu Glu Gly Glu Phe
    370                 375                 380                 
Gly Lys Lys Ala Asp Gly Leu Leu Gly Met Phe Leu Lys Arg Leu Ser
385                 390                 395                 400 
Ser Gln Leu Ile Leu Leu Gln Ala Trp Thr Ser His Leu Trp Lys Met
                405                 410                 415     
Phe Tyr Asp Ala Arg Lys Pro Arg Ser Gln Ile Lys Asn Glu Ile Asn
            420                 425                 430         
Ile Asp Thr Leu Ala Arg Asp Glu Phe Asn Leu Gln Lys Met Met Val
        435                 440                 445             
Met Val Thr Ala Ser Gly Lys Leu Phe Gly Ile Glu Ser Ser Ser Gly
    450                 455                 460                 
Thr Ile Leu Trp Lys Gln Tyr Leu Pro Asn Val Lys Pro Asp Ser Ser
465                 470                 475                 480 
Phe Lys Leu Met Val Gln Arg Thr Thr Ala His Phe Pro His Pro Pro
                485                 490                 495     
Gln Cys Thr Leu Leu Val Lys Asp Lys Glu Ser Gly Met Ser Ser Leu
            500                 505                 510         
Tyr Val Phe Asn Pro Ile Phe Gly Lys Trp Ser Gln Val Ala Pro Pro
        515                 520                 525             
Val Leu Lys Arg Pro Ile Leu Gln Ser Leu Leu Leu Pro Val Met Asp
    530                 535                 540                 
Gln Asp Tyr Ala Lys Val Leu Leu Leu Ile Asp Asp Glu Tyr Lys Val
545                 550                 555                 560 
Thr Ala Phe Pro Ala Thr Arg Asn Val Leu Arg Gln Leu His Glu Leu
                565                 570                 575     
Ala Pro Ser Ile Phe Phe Tyr Leu Val Asp Ala Glu Gln Gly Arg Leu
            580                 585                 590         
Cys Gly Tyr Arg Leu Arg Lys Asp Leu Thr Thr Glu Leu Ser Trp Glu
        595                 600                 605             
Leu Thr Ile Pro Pro Glu Val Gln Arg Ile Val Lys Val Lys Gly Lys
    610                 615                 620                 
Arg Ser Ser Glu His Val His Ser Gln Gly Arg Val Met Gly Asp Arg
625                 630                 635                 640 
Ser Val Leu Tyr Lys Ser Leu Asn Pro Asn Leu Leu Ala Val Val Thr
                645                 650                 655     
Glu Ser Thr Asp Ala His His Glu Arg Thr Phe Ile Gly Ile Phe Leu
            660                 665                 670         
Ile Asp Gly Val Thr Gly Arg Ile Ile His Ser Ser Val Gln Lys Lys
        675                 680                 685             
Ala Lys Gly Pro Val His Ile Val His Ser Glu Asn Trp Val Val Tyr
    690                 695                 700                 
Gln Tyr Trp Asn Thr Lys Ala Arg Arg Asn Glu Phe Thr Val Leu Glu
705                 710                 715                 720 
Leu Tyr Glu Gly Thr Glu Gln Tyr Asn Ala Thr Ala Phe Ser Ser Leu
                725                 730                 735     
Asp Arg Pro Gln Leu Pro Gln Val Leu Gln Gln Ser Tyr Ile Phe Pro
            740                 745                 750         
Ser Ser Ile Ser Ala Met Glu Ala Thr Ile Thr Glu Arg Gly Ile Thr
        755                 760                 765             
Ser Arg His Leu Leu Ile Gly Leu Pro Ser Gly Ala Ile Leu Ser Leu
    770                 775                 780                 
Pro Lys Ala Leu Leu Asp Pro Arg Arg Pro Glu Ile Pro Thr Glu Gln
785                 790                 795                 800 
Ser Arg Glu Glu Asn Leu Ile Pro Tyr Ser Pro Asp Val Gln Ile His
                805                 810                 815     
Ala Glu Arg Phe Ile Asn Tyr Asn Gln Thr Val Ser Arg Met Arg Gly
            820                 825                 830         
Ile Tyr Thr Ala Pro Ser Gly Leu Glu Ser Thr Cys Leu Val Val Ala
        835                 840                 845             
Tyr Gly Leu Asp Ile Tyr Gln Thr Arg Val Tyr Pro Ser Lys Gln Phe
    850                 855                 860                 
Asp Val Leu Lys Asp Asp Tyr Asp Tyr Val Leu Ile Ser Ser Val Leu
865                 870                 875                 880 
Phe Gly Leu Val Phe Ala Thr Met Ile Thr Lys Arg Leu Ala Gln Val
                885                 890                 895     
Lys Leu Leu Asn Arg Ala Trp Arg
            900                 


<210> 2000
<211> 711
<212> PRT
<213> Homo sapiens

<400> 2000
Met Lys Leu Val Phe Leu Val Leu Leu Phe Leu Gly Ala Leu Gly Leu
 1               5                  10                  15      
Cys Leu Ala Gly Arg Arg Arg Arg Ser Val Gln Trp Cys Thr Val Ser
            20                  25                  30          
Gln Pro Glu Ala Thr Lys Cys Phe Gln Trp Gln Arg Asn Met Arg Arg
        35                  40                  45              
Val Arg Gly Pro Pro Val Ser Cys Ile Lys Arg Asp Ser Pro Ile Gln
    50                  55                  60                  
Cys Ile Gln Ala Ile Ala Glu Asn Arg Ala Asp Ala Val Thr Leu Asp
65                  70                  75                  80  
Gly Gly Phe Ile Tyr Glu Ala Gly Leu Ala Pro Tyr Lys Leu Arg Pro
                85                  90                  95      
Val Ala Ala Glu Val Tyr Gly Thr Glu Arg Gln Pro Arg Thr His Tyr
            100                 105                 110         
Tyr Ala Val Ala Val Val Lys Lys Gly Gly Ser Phe Gln Leu Asn Glu
        115                 120                 125             
Leu Gln Gly Leu Lys Ser Cys His Thr Gly Leu Arg Arg Thr Ala Gly
    130                 135                 140                 
Trp Asn Val Pro Ile Gly Thr Leu Arg Pro Phe Leu Asn Trp Thr Gly
145                 150                 155                 160 
Pro Pro Glu Pro Ile Glu Ala Ala Val Ala Arg Phe Phe Ser Ala Ser
                165                 170                 175     
Cys Val Pro Gly Ala Asp Lys Gly Gln Phe Pro Asn Leu Cys Arg Leu
            180                 185                 190         
Cys Ala Gly Thr Gly Glu Asn Lys Cys Ala Phe Ser Ser Gln Glu Pro
        195                 200                 205             
Tyr Phe Ser Tyr Ser Gly Ala Phe Lys Cys Leu Arg Asp Gly Ala Gly
    210                 215                 220                 
Asp Val Ala Phe Ile Arg Glu Ser Thr Val Phe Glu Asp Leu Ser Asp
225                 230                 235                 240 
Glu Ala Glu Arg Asp Glu Tyr Glu Leu Leu Cys Pro Asp Asn Thr Arg
                245                 250                 255     
Lys Pro Val Asp Lys Phe Lys Asp Cys His Leu Ala Arg Val Pro Ser
            260                 265                 270         
His Ala Val Val Ala Arg Ser Val Asn Gly Lys Glu Asp Ala Ile Trp
        275                 280                 285             
Asn Leu Leu Arg Gln Ala Gln Glu Lys Phe Gly Lys Asp Lys Ser Pro
    290                 295                 300                 
Lys Phe Gln Leu Phe Gly Ser Pro Ser Gly Gln Lys Asp Leu Leu Phe
305                 310                 315                 320 
Lys Asp Ser Ala Ile Gly Phe Ser Arg Val Pro Pro Arg Ile Asp Ser
                325                 330                 335     
Gly Leu Tyr Leu Gly Ser Gly Tyr Phe Thr Ala Ile Gln Asn Leu Arg
            340                 345                 350         
Lys Ser Glu Glu Glu Val Ala Ala Arg Arg Ala Arg Val Val Trp Cys
        355                 360                 365             
Ala Val Gly Glu Gln Glu Leu Arg Lys Cys Asn Gln Trp Ser Gly Leu
    370                 375                 380                 
Ser Glu Gly Ser Val Thr Cys Ser Ser Ala Ser Thr Thr Glu Asp Cys
385                 390                 395                 400 
Ile Ala Leu Val Leu Lys Gly Glu Ala Asp Ala Met Ser Leu Asp Gly
                405                 410                 415     
Gly Tyr Val Tyr Thr Ala Gly Lys Cys Gly Leu Val Pro Val Leu Ala
            420                 425                 430         
Glu Asn Tyr Lys Ser Gln Gln Ser Ser Asp Pro Asp Pro Asn Cys Val
        435                 440                 445             
Asp Arg Pro Val Glu Gly Tyr Leu Ala Val Ala Val Val Arg Arg Ser
    450                 455                 460                 
Asp Thr Ser Leu Thr Trp Asn Ser Val Lys Gly Lys Lys Ser Cys His
465                 470                 475                 480 
Thr Ala Val Asp Arg Thr Ala Gly Trp Asn Ile Pro Met Gly Leu Leu
                485                 490                 495     
Phe Asn Gln Thr Gly Ser Cys Lys Phe Asp Glu Tyr Phe Ser Gln Ser
            500                 505                 510         
Cys Ala Pro Gly Ser Asp Pro Arg Ser Asn Leu Cys Ala Leu Cys Ile
        515                 520                 525             
Gly Asp Glu Gln Gly Glu Asn Lys Cys Val Pro Asn Ser Asn Glu Arg
    530                 535                 540                 
Tyr Tyr Gly Tyr Thr Gly Ala Phe Arg Cys Leu Ala Glu Asn Ala Gly
545                 550                 555                 560 
Asp Val Ala Phe Val Lys Asp Val Thr Val Leu Gln Asn Thr Asp Gly
                565                 570                 575     
Asn Asn Asn Asp Ala Trp Ala Lys Asp Leu Lys Leu Ala Asp Phe Ala
            580                 585                 590         
Leu Leu Cys Leu Asp Gly Lys Arg Lys Pro Val Thr Glu Ala Arg Ser
        595                 600                 605             
Cys His Leu Ala Met Ala Pro Asn His Ala Val Val Ser Arg Met Asp
    610                 615                 620                 
Lys Val Glu Arg Leu Lys Gln Val Leu Leu His Gln Gln Ala Lys Phe
625                 630                 635                 640 
Gly Arg Asn Gly Ser Asp Cys Pro Asp Lys Phe Cys Leu Phe Gln Ser
                645                 650                 655     
Glu Thr Lys Asn Leu Leu Phe Asn Asp Asn Thr Glu Cys Leu Ala Arg
            660                 665                 670         
Leu His Gly Lys Thr Thr Tyr Glu Lys Tyr Leu Gly Pro Gln Tyr Val
        675                 680                 685             
Ala Gly Ile Thr Asn Leu Lys Lys Cys Ser Thr Ser Pro Leu Leu Glu
    690                 695                 700                 
Ala Cys Glu Phe Leu Arg Lys
705                 710     


<210> 2001
<211> 309
<212> PRT
<213> Homo sapiens

<400> 2001
Met Ser Trp Cys Asn Glu Leu Arg Leu Pro Ala Leu Lys Gln His Ser
 1               5                  10                  15      
Ile Gly Arg Gly Leu Glu Ser His Ile Thr Met Cys Ile Pro Pro Ser
            20                  25                  30          
Tyr Ala Asp Leu Gly Lys Ala Ala Arg Asp Ile Phe Asn Lys Gly Phe
        35                  40                  45              
Gly Phe Gly Leu Val Lys Leu Asp Val Lys Thr Lys Ser Cys Ser Gly
    50                  55                  60                  
Val Glu Phe Ser Thr Ser Gly Ser Ser Asn Thr Asp Thr Gly Lys Val
65                  70                  75                  80  
Thr Gly Thr Leu Glu Thr Lys Tyr Lys Trp Cys Glu Tyr Gly Leu Thr
                85                  90                  95      
Phe Thr Glu Lys Trp Asn Thr Asp Asn Thr Leu Gly Thr Glu Ile Ala
            100                 105                 110         
Ile Glu Asp Gln Ile Cys Gln Gly Leu Lys Leu Thr Phe Asp Thr Thr
        115                 120                 125             
Phe Ser Pro Asn Thr Gly Lys Lys Ser Gly Lys Ile Lys Ser Ser Tyr
    130                 135                 140                 
Lys Arg Glu Cys Ile Asn Leu Gly Cys Asp Val Asp Phe Asp Phe Ala
145                 150                 155                 160 
Gly Pro Ala Ile His Gly Ser Ala Val Phe Gly Tyr Glu Gly Trp Leu
                165                 170                 175     
Ala Gly Tyr Gln Met Thr Phe Asp Ser Ala Lys Ser Lys Leu Thr Arg
            180                 185                 190         
Asn Asn Phe Ala Val Gly Tyr Arg Thr Gly Asp Phe Gln Leu His Thr
        195                 200                 205             
Asn Val Asn Asp Gly Thr Glu Phe Gly Gly Ser Ile Tyr Gln Lys Val
    210                 215                 220                 
Cys Glu Asp Leu Asp Thr Ser Val Asn Leu Ala Trp Thr Ser Gly Thr
225                 230                 235                 240 
Asn Cys Thr Arg Phe Gly Ile Ala Ala Lys Tyr Gln Leu Asp Pro Thr
                245                 250                 255     
Ala Ser Ile Ser Ala Lys Val Asn Asn Ser Ser Leu Ile Gly Val Gly
            260                 265                 270         
Tyr Thr Gln Thr Leu Arg Pro Gly Val Lys Leu Thr Leu Ser Ala Leu
        275                 280                 285             
Val Asp Gly Lys Ser Ile Asn Ala Gly Gly His Lys Val Gly Leu Ala
    290                 295                 300                 
Leu Glu Leu Glu Ala
305                 


<210> 2002
<211> 387
<212> PRT
<213> Homo sapiens

<400> 2002
Met Glu Ser Asn Lys Asp Glu Ala Glu Arg Cys Ile Ser Ile Ala Leu
 1               5                  10                  15      
Lys Ala Ile Gln Ser Asn Gln Pro Asp Arg Ala Leu Arg Phe Leu Glu
            20                  25                  30          
Lys Ala Gln Arg Leu Tyr Pro Thr Pro Arg Val Arg Ala Leu Ile Glu
        35                  40                  45              
Ser Leu Asn Gln Lys Pro Gln Thr Ala Gly Asp Gln Pro Pro Pro Thr
    50                  55                  60                  
Asp Thr Thr His Ala Thr His Arg Lys Ala Gly Gly Thr Asp Ala Pro
65                  70                  75                  80  
Ser Ala Asn Gly Glu Ala Gly Gly Glu Ser Thr Lys Gly Tyr Thr Ala
                85                  90                  95      
Glu Gln Val Ala Ala Val Lys Arg Val Lys Gln Cys Lys Asp Tyr Tyr
            100                 105                 110         
Glu Ile Leu Gly Val Ser Arg Gly Ala Ser Asp Glu Asp Leu Lys Lys
        115                 120                 125             
Ala Tyr Arg Arg Leu Ala Leu Lys Phe His Pro Asp Lys Asn His Ala
    130                 135                 140                 
Pro Gly Ala Thr Glu Ala Phe Lys Ala Ile Gly Thr Ala Tyr Ala Val
145                 150                 155                 160 
Leu Ser Asn Pro Glu Lys Arg Lys Gln Tyr Asp Gln Phe Gly Asp Asp
                165                 170                 175     
Lys Ser Gln Ala Ala Arg His Gly His Gly His Gly Asp Phe His Arg
            180                 185                 190         
Gly Phe Glu Ala Asp Ile Ser Pro Glu Asp Leu Phe Asn Met Phe Phe
        195                 200                 205             
Gly Gly Gly Phe Pro Ser Ser Asn Val His Val Tyr Ser Asn Gly Arg
    210                 215                 220                 
Met Arg Tyr Thr Tyr Gln Gln Arg Gln Asp Arg Arg Asp Asn Gln Gly
225                 230                 235                 240 
Asp Ala Gly Leu Gly Val Phe Val Gln Leu Met Pro Ile Leu Ile Leu
                245                 250                 255     
Ile Leu Val Ser Ala Leu Ser Gln Leu Met Val Ser Ser Pro Pro Tyr
            260                 265                 270         
Ser Leu Ser Pro Arg Pro Ser Val Gly His Ile His Arg Arg Val Thr
        275                 280                 285             
Asp His Leu Gly Val Val Tyr Tyr Val Gly Asp Thr Phe Ser Glu Glu
    290                 295                 300                 
Tyr Thr Gly Ser Ser Leu Lys Thr Val Glu Arg Asn Val Glu Asp Asp
305                 310                 315                 320 
Tyr Ile Ala Asn Leu Arg Asn Asn Cys Trp Lys Glu Lys Gln Gln Arg
                325                 330                 335     
Lys Ala Cys Cys Thr Gly His Ala Thr Leu Ala Thr Gln Ile Cys Thr
            340                 345                 350         
Thr Glu His Arg Arg Trp Ala Pro Pro Ala Ala Ala Asp Cys Gln Arg
        355                 360                 365             
Cys Arg Pro Pro Cys Met Asp Ser Pro Gly Pro Ala Thr Pro Pro Arg
    370                 375                 380                 
Ser Lys Leu
385         


<210> 2003
<211> 636
<212> PRT
<213> Homo sapiens

<400> 2003
Met Asn Phe Val Lys Leu Leu His Ala Tyr Asn Arg Thr His Leu Leu
 1               5                  10                  15      
Ala Cys Gly Thr Gly Ala Phe His Pro Thr Cys Ala Phe Val Glu Val
            20                  25                  30          
Gly His Arg Ala Glu Glu Pro Val Leu Arg Leu Asp Pro Gly Arg Ile
        35                  40                  45              
Glu Asp Gly Lys Gly Lys Ser Pro Tyr Asp Pro Arg His Arg Ala Ala
    50                  55                  60                  
Ser Val Leu Val Gly Glu Glu Leu Tyr Ser Gly Val Ala Ala Asp Leu
65                  70                  75                  80  
Met Gly Arg Asp Phe Thr Ile Phe Arg Ser Leu Gly Gln Arg Pro Ser
                85                  90                  95      
Leu Arg Thr Glu Pro His Asp Ser Arg Trp Leu Asn Glu Pro Lys Phe
            100                 105                 110         
Val Lys Val Phe Trp Ile Pro Glu Ser Glu Asn Pro Asp Asp Asp Lys
        115                 120                 125             
Ile Tyr Phe Phe Phe Arg Glu Thr Ala Val Glu Ala Ala Pro Ala Leu
    130                 135                 140                 
Gly Arg Leu Ser Val Ser Arg Val Gly Gln Ile Cys Arg Asn Asp Val
145                 150                 155                 160 
Gly Gly Gln Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys Ala
                165                 170                 175     
Arg Leu Val Cys Ser Val Pro Gly Val Glu Gly Asp Thr His Phe Asp
            180                 185                 190         
Gln Leu Gln Asp Val Phe Leu Leu Ser Ser Arg Asp His Arg Thr Pro
        195                 200                 205             
Leu Leu Tyr Ala Val Phe Ser Thr Ser Ser Ser Ile Phe Gln Gly Ser
    210                 215                 220                 
Ala Val Cys Val Tyr Ser Met Asn Asp Val Arg Arg Ala Phe Leu Gly
225                 230                 235                 240 
Pro Phe Ala His Lys Glu Gly Pro Met His Gln Trp Val Ser Tyr Gln
                245                 250                 255     
Gly Arg Val Pro Tyr Pro Arg Pro Gly Met Cys Pro Ser Lys Thr Phe
            260                 265                 270         
Gly Thr Phe Ser Ser Thr Lys Asp Phe Pro Asp Asp Val Ile Gln Phe
        275                 280                 285             
Ala Arg Asn His Pro Leu Met Tyr Asn Ser Val Leu Pro Thr Gly Gly
    290                 295                 300                 
Arg Pro Leu Phe Leu Gln Val Gly Ala Asn Tyr Thr Phe Thr Gln Ile
305                 310                 315                 320 
Ala Ala Asp Arg Val Ala Ala Ala Asp Gly His Tyr Asp Val Leu Phe
                325                 330                 335     
Ile Gly Thr Asp Val Gly Thr Val Leu Lys Val Ile Ser Val Pro Lys
            340                 345                 350         
Gly Ser Arg Pro Ser Ala Glu Gly Leu Leu Leu Glu Glu Leu His Val
        355                 360                 365             
Phe Glu Asp Ser Ala Ala Val Thr Ser Met Gln Ile Ser Ser Lys Arg
    370                 375                 380                 
His Gln Leu Tyr Val Ala Ser Arg Ser Ala Val Ala Gln Ile Ala Leu
385                 390                 395                 400 
His Arg Cys Ala Ala His Gly Arg Val Cys Thr Glu Cys Cys Leu Ala
                405                 410                 415     
Arg Asp Pro Tyr Cys Ala Trp Asp Gly Val Ala Cys Thr Arg Phe Gln
            420                 425                 430         
Pro Ser Ala Lys Arg Arg Phe Arg Arg Gln Asp Val Arg Asn Gly Asp
        435                 440                 445             
Pro Ser Thr Leu Cys Ser Gly Asp Ser Ser Arg Pro Ala Leu Leu Glu
    450                 455                 460                 
His Lys Val Phe Gly Val Glu Gly Ser Ser Ala Phe Leu Glu Cys Glu
465                 470                 475                 480 
Pro Arg Ser Leu Gln Ala Arg Val Glu Trp Thr Phe Gln Arg Ala Gly
                485                 490                 495     
Val Thr Ala His Thr Gln Val Leu Ala Glu Glu Arg Thr Glu Arg Thr
            500                 505                 510         
Ala Arg Gly Leu Leu Leu Arg Arg Leu Arg Arg Arg Asp Ser Gly Val
        515                 520                 525             
Tyr Leu Cys Ala Ala Val Glu Gln Gly Phe Thr Gln Pro Leu Arg Arg
    530                 535                 540                 
Leu Ser Leu His Val Leu Ser Ala Thr Gln Ala Glu Arg Leu Ala Arg
545                 550                 555                 560 
Ala Glu Glu Ala Ala Pro Ala Ala Pro Pro Gly Pro Lys Leu Trp Tyr
                565                 570                 575     
Arg Asp Phe Leu Gln Leu Val Glu Pro Gly Gly Gly Gly Ser Ala Asn
            580                 585                 590         
Ser Leu Arg Met Cys Arg Pro Gln Pro Ala Leu Gln Ser Leu Pro Leu
        595                 600                 605             
Glu Ser Arg Arg Lys Gly Arg Asn Arg Arg Thr His Ala Pro Glu Pro
    610                 615                 620                 
Arg Ala Glu Arg Gly Pro Arg Ser Ala Thr His Trp
625                 630                 635     


<210> 2004
<211> 296
<212> PRT
<213> Homo sapiens

<400> 2004
Met Ala Ala Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser
 1               5                  10                  15      
Thr Ser Ser Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg
            20                  25                  30          
Leu Ser Leu Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr
        35                  40                  45              
Ala Leu Ala Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu
    50                  55                  60                  
Glu Thr Gln Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly
65                  70                  75                  80  
Arg Pro Gly Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu
                85                  90                  95      
Gly Cys Asp Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Glu Glu Asp
            100                 105                 110         
Cys Gln Lys Tyr Ile Leu Lys Gln Gln Gln Glu Glu Ala Glu Lys Pro
        115                 120                 125             
Leu Gln Val Ala Ala Val Asp Ser Ser Val Pro Arg Thr Ala Glu Leu
    130                 135                 140                 
Ala Gly Ile Thr Thr Leu Asp Asp Pro Leu Gly His Met Pro Glu Arg
145                 150                 155                 160 
Phe Asp Ala Phe Ile Cys Tyr Cys Pro Ser Asp Ile Gln Phe Val Gln
                165                 170                 175     
Glu Met Ile Arg Gln Leu Glu Gln Thr Asn Tyr Arg Leu Lys Leu Cys
            180                 185                 190         
Val Ser Asp Arg Asp Val Leu Pro Gly Thr Cys Val Trp Ser Ile Ala
        195                 200                 205             
Ser Glu Leu Ile Glu Lys Arg Cys Arg Arg Met Val Val Val Val Ser
    210                 215                 220                 
Asp Asp Tyr Leu Gln Ser Lys Glu Cys Asp Phe Gln Thr Lys Phe Ala
225                 230                 235                 240 
Leu Ser Leu Ser Pro Gly Ala His Gln Lys Arg Leu Ile Pro Ile Lys
                245                 250                 255     
Tyr Lys Ala Met Lys Lys Glu Phe Pro Ser Ile Leu Arg Phe Ile Thr
            260                 265                 270         
Val Cys Asp Tyr Thr Asn Pro Cys Thr Lys Ser Trp Phe Trp Thr Arg
        275                 280                 285             
Leu Ala Lys Ala Leu Ser Leu Pro
    290                 295     


<210> 2005
<211> 253
<212> PRT
<213> Homo sapiens

<400> 2005
Met Glu Thr Arg Pro Met Thr Leu Glu Glu Met Glu Glu Val Gly Lys
 1               5                  10                  15      
Arg Tyr Arg Glu Arg Gln Arg Gln His Lys Leu Thr Ile Pro Ser Ile
            20                  25                  30          
Gln Tyr Thr Glu Gln Cys His Leu Val Arg Cys Gly Asn Arg His Phe
        35                  40                  45              
Asp Glu His Cys Leu Pro Ser Thr Ile His Gly Asp Met Arg Glu Leu
    50                  55                  60                  
Ile Asp Ser Ala Arg Arg His Asn Phe Leu Val Tyr Leu Gln Cys Trp
65                  70                  75                  80  
Lys Leu Cys Lys Ser Tyr Gly Leu Pro Leu Thr Glu Asp Ile Leu Met
                85                  90                  95      
Lys Ala Leu Leu Tyr Pro Gly Asp Lys Ile Ile Phe Gln Met Asp Lys
            100                 105                 110         
Val Cys Pro Ile Arg Gln Pro Gly Gly Tyr Tyr Ser Asp Trp Lys Val
        115                 120                 125             
Phe Ser Pro Asn Leu Ala Leu Leu Arg Ser Gln Gly Pro Gly Lys Ser
    130                 135                 140                 
Lys Arg Thr Asp Lys Lys Thr Pro Lys Lys Ser Lys Lys Met Arg Phe
145                 150                 155                 160 
Lys Glu Phe Glu Glu Phe Thr Arg Lys Leu Lys Val Lys Arg Ser Ser
                165                 170                 175     
Gly Leu Gln Gln Thr His Pro Asn Ser Phe Trp Pro Gly His Leu Leu
            180                 185                 190         
Asp Lys Leu Gln Leu Tyr Leu Pro Thr Val Ala Thr Asp Arg Ser Leu
        195                 200                 205             
Ala Leu Phe Ser Cys Val Gln His Gln Pro His Val Tyr Pro Ala Thr
    210                 215                 220                 
Tyr His Pro Asp His Trp Trp Pro Leu Arg Asn Lys Asn Tyr Met Thr
225                 230                 235                 240 
His Ala His Tyr Asp Ala Ala Lys Val Tyr Tyr Ile Asn
                245                 250             


<210> 2006
<211> 856
<212> PRT
<213> Homo sapiens

<400> 2006
Met Asp Glu Asp Ser Ser Leu Arg Asp Tyr Thr Val Ser Leu Asp Ser
 1               5                  10                  15      
Asp Met Asp Asp Ala Ser Lys Phe Leu Gln Asp Tyr Asp Ile Arg Thr
            20                  25                  30          
Gly Asn Thr Arg Glu Ala Leu Ser Pro Cys Pro Ser Thr Val Ser Thr
        35                  40                  45              
Lys Ser Gln Pro Gly Ser Ser Ala Ser Ser Ser Ser Gly Val Lys Met
    50                  55                  60                  
Thr Ser Phe Ala Glu Gln Lys Phe Arg Lys Leu Asn His Thr Asp Gly
65                  70                  75                  80  
Lys Ser Ser Gly Ser Ser Ser Gln Lys Thr Thr Pro Glu Gly Ser Glu
                85                  90                  95      
Leu Asn Ile Pro His Val Val Ala Trp Ala Gln Ile Pro Glu Glu Thr
            100                 105                 110         
Gly Leu Pro Gln Gly Arg Asp Thr Thr Gln Leu Leu Ala Ser Glu Met
        115                 120                 125             
Val His Leu Arg Met Lys Leu Glu Glu Lys Arg Arg Ala Ile Glu Ala
    130                 135                 140                 
Gln Lys Lys Lys Met Glu Ala Ala Phe Thr Lys Gln Arg Gln Lys Met
145                 150                 155                 160 
Gly Arg Thr Ala Phe Leu Thr Val Val Lys Lys Lys Gly Asp Gly Ile
                165                 170                 175     
Ser Pro Leu Arg Glu Glu Ala Ala Gly Ala Glu Asp Glu Lys Val Tyr
            180                 185                 190         
Thr Asp Arg Ala Lys Glu Lys Glu Ser Gln Lys Thr Asp Gly Gln Arg
        195                 200                 205             
Ser Lys Ser Leu Ala Asp Ile Lys Glu Ser Met Glu Asn Pro Gln Ala
    210                 215                 220                 
Lys Trp Leu Lys Ser Pro Thr Thr Pro Ile Asp Pro Glu Lys Gln Trp
225                 230                 235                 240 
Asn Leu Ala Ser Pro Ser Glu Glu Thr Leu Asn Glu Gly Glu Ile Leu
                245                 250                 255     
Glu Tyr Thr Lys Ser Ile Glu Lys Leu Asn Ser Ser Leu His Phe Leu
            260                 265                 270         
Gln Gln Glu Met Gln Arg Leu Ser Leu Gln Gln Glu Met Leu Met Gln
        275                 280                 285             
Met Arg Glu Gln Gln Ser Trp Val Ile Ser Pro Pro Gln Pro Ser Pro
    290                 295                 300                 
Gln Lys Gln Ile Arg Asp Phe Lys Pro Ser Lys Gln Ala Gly Leu Ser
305                 310                 315                 320 
Ser Ala Ile Ala Pro Phe Ser Ser Asp Ser Pro Arg Pro Thr His Pro
                325                 330                 335     
Ser Pro Gln Ser Ser Asn Arg Lys Ser Ala Ser Phe Ser Val Lys Ser
            340                 345                 350         
Gln Arg Thr Pro Arg Pro Asn Glu Leu Lys Ile Thr Pro Leu Asn Arg
        355                 360                 365             
Thr Leu Thr Pro Pro Arg Ser Val Asp Ser Leu Pro Arg Leu Arg Arg
    370                 375                 380                 
Phe Ser Pro Ser Gln Val Pro Ile Gln Thr Arg Ser Phe Val Cys Phe
385                 390                 395                 400 
Gly Asp Asp Gly Glu Pro Gln Leu Lys Glu Ser Lys Pro Lys Glu Glu
                405                 410                 415     
Val Lys Lys Glu Glu Leu Glu Ser Lys Gly Thr Leu Glu Gln Arg Gly
            420                 425                 430         
His Asn Pro Glu Glu Lys Glu Ile Lys Pro Phe Glu Ser Thr Val Ser
        435                 440                 445             
Glu Val Leu Ser Leu Pro Val Thr Glu Thr Val Cys Leu Thr Pro Asn
    450                 455                 460                 
Glu Asp Gln Leu Asn Gln Pro Thr Glu Pro Pro Pro Lys Pro Val Phe
465                 470                 475                 480 
Pro Pro Thr Ala Pro Lys Asn Val Asn Leu Ile Glu Val Ser Leu Ser
                485                 490                 495     
Asp Leu Lys Pro Pro Glu Lys Ala Asp Val Pro Val Glu Lys Tyr Asp
            500                 505                 510         
Gly Glu Ser Asp Lys Glu Gln Phe Asp Asp Asp Gln Lys Val Cys Cys
        515                 520                 525             
Gly Phe Phe Phe Lys Asp Asp Gln Lys Ala Glu Asn Asp Met Ala Met
    530                 535                 540                 
Lys Arg Ala Ala Leu Leu Glu Lys Arg Leu Arg Arg Glu Lys Glu Thr
545                 550                 555                 560 
Gln Leu Arg Lys Gln Gln Leu Glu Ala Glu Met Glu His Lys Lys Glu
                565                 570                 575     
Glu Thr Arg Arg Lys Thr Glu Glu Glu Arg Gln Lys Lys Glu Asp Glu
            580                 585                 590         
Arg Ala Arg Arg Glu Phe Ile Arg Gln Glu Tyr Met Arg Arg Lys Gln
        595                 600                 605             
Leu Lys Leu Met Glu Asp Met Asp Thr Val Ile Lys Pro Arg Pro Gln
    610                 615                 620                 
Val Val Lys Gln Lys Lys Gln Arg Pro Lys Ser Ile His Arg Asp His
625                 630                 635                 640 
Ile Glu Ser Pro Lys Thr Pro Ile Lys Gly Pro Pro Val Ser Ser Leu
                645                 650                 655     
Ser Leu Ala Ser Leu Asn Thr Gly Asp Asn Glu Ser Val His Ser Gly
            660                 665                 670         
Lys Arg Thr Pro Arg Ser Glu Ser Val Glu Gly Phe Leu Ser Pro Ser
        675                 680                 685             
Arg Cys Gly Ser Arg Asn Gly Glu Lys Asp Trp Glu Asn Ala Ser Thr
    690                 695                 700                 
Thr Ser Ser Val Ala Ser Gly Thr Glu Tyr Thr Gly Pro Lys Leu Tyr
705                 710                 715                 720 
Lys Glu Pro Ser Ala Lys Ser Asn Lys His Ile Ile Gln Asn Ala Leu
                725                 730                 735     
Ala His Cys Cys Leu Ala Gly Lys Val Asn Glu Gly Gln Lys Lys Lys
            740                 745                 750         
Ile Leu Glu Glu Met Glu Lys Ser Asp Ala Asn Asn Phe Leu Ile Leu
        755                 760                 765             
Phe Arg Asp Ser Gly Cys Gln Phe Arg Ser Leu Tyr Thr Tyr Cys Pro
    770                 775                 780                 
Glu Thr Glu Glu Ile Asn Lys Leu Thr Gly Ile Gly Pro Lys Ser Ile
785                 790                 795                 800 
Thr Lys Lys Met Ile Glu Gly Leu Tyr Lys Tyr Asn Ser Asp Arg Lys
                805                 810                 815     
Gln Phe Ser His Ile Pro Ala Lys Thr Leu Ser Ala Ser Val Asp Ala
            820                 825                 830         
Ile Thr Ile His Ser His Leu Trp Gln Thr Lys Arg Pro Val Thr Pro
        835                 840                 845             
Lys Lys Leu Leu Pro Thr Lys Ala
    850                 855     


<210> 2007
<211> 586
<212> PRT
<213> Homo sapiens

<400> 2007
Met Glu Ser Asn His Lys Ser Gly Asp Gly Leu Ser Gly Thr Gln Lys
 1               5                  10                  15      
Glu Ala Ala Leu Arg Ala Leu Val Gln Arg Thr Gly Tyr Ser Leu Val
            20                  25                  30          
Gln Glu Asn Gly Gln Arg Lys Tyr Gly Gly Pro Pro Pro Gly Trp Asp
        35                  40                  45              
Ala Ala Pro Pro Glu Arg Gly Cys Glu Ile Phe Ile Gly Lys Leu Pro
    50                  55                  60                  
Arg Asp Leu Phe Glu Asp Glu Leu Ile Pro Leu Cys Glu Lys Ile Gly
65                  70                  75                  80  
Lys Ile Tyr Glu Met Arg Met Met Met Asp Phe Asn Gly Asn Asn Arg
                85                  90                  95      
Gly Tyr Ala Phe Val Thr Phe Ser Asn Lys Val Glu Ala Lys Asn Ala
            100                 105                 110         
Ile Lys Gln Leu Asn Asn Tyr Glu Ile Arg Asn Gly Arg Leu Leu Gly
        115                 120                 125             
Val Cys Ala Ser Val Asp Asn Cys Arg Leu Phe Val Gly Gly Ile Pro
    130                 135                 140                 
Lys Thr Lys Lys Arg Glu Glu Ile Leu Ser Glu Met Lys Lys Val Thr
145                 150                 155                 160 
Glu Gly Val Val Asp Val Ile Val Tyr Pro Ser Ala Ala Asp Lys Thr
                165                 170                 175     
Lys Asn Arg Gly Phe Ala Phe Val Glu Tyr Glu Ser His Arg Ala Ala
            180                 185                 190         
Ala Met Ala Arg Arg Lys Leu Leu Pro Gly Arg Ile Gln Leu Trp Gly
        195                 200                 205             
His Gly Ile Ala Val Asp Trp Ala Glu Pro Glu Val Glu Val Asp Glu
    210                 215                 220                 
Asp Thr Met Ser Ser Val Lys Ile Leu Tyr Val Arg Asn Leu Met Leu
225                 230                 235                 240 
Ser Thr Ser Glu Glu Met Ile Glu Lys Glu Phe Asn Asn Ile Lys Pro
                245                 250                 255     
Gly Ala Val Glu Arg Val Lys Lys Ile Arg Asp Tyr Ala Phe Val His
            260                 265                 270         
Phe Ser Asn Arg Glu Asp Ala Val Glu Ala Met Lys Ala Leu Asn Gly
        275                 280                 285             
Lys Val Leu Asp Gly Ser Pro Ile Glu Val Thr Leu Ala Lys Pro Val
    290                 295                 300                 
Asp Lys Asp Ser Tyr Val Arg Tyr Thr Arg Gly Thr Gly Gly Arg Gly
305                 310                 315                 320 
Thr Met Leu Gln Gly Glu Tyr Thr Tyr Ser Leu Gly Gln Val Tyr Asp
                325                 330                 335     
Pro Thr Thr Thr Tyr Leu Gly Ala Pro Val Phe Tyr Ala Pro Gln Thr
            340                 345                 350         
Tyr Ala Ala Ile Pro Ser Leu His Phe Pro Ala Thr Lys Gly His Leu
        355                 360                 365             
Ser Asn Arg Ala Ile Ile Arg Ala Pro Ser Val Arg Gly Ala Ala Gly
    370                 375                 380                 
Val Arg Gly Leu Gly Gly Arg Gly Tyr Leu Ala Tyr Thr Gly Leu Gly
385                 390                 395                 400 
Arg Gly Tyr Gln Val Lys Gly Asp Lys Arg Glu Asp Lys Leu Tyr Asp
                405                 410                 415     
Ile Leu Pro Gly Met Glu Leu Thr Pro Met Asn Pro Val Thr Leu Lys
            420                 425                 430         
Pro Gln Gly Ile Lys Leu Ala Pro Gln Ile Leu Glu Glu Ile Cys Gln
        435                 440                 445             
Lys Asn Asn Trp Gly Gln Pro Val Tyr Gln Leu His Ser Ala Ile Gly
    450                 455                 460                 
Gln Asp Gln Arg Gln Leu Phe Leu Tyr Lys Ile Thr Ile Pro Ala Leu
465                 470                 475                 480 
Ala Ser Gln Asn Pro Ala Ile His Pro Phe Thr Pro Pro Lys Leu Ser
                485                 490                 495     
Ala Phe Val Asp Glu Ala Lys Thr Tyr Ala Ala Glu Tyr Thr Leu Gln
            500                 505                 510         
Thr Leu Gly Ile Pro Thr Asp Gly Gly Asp Gly Thr Met Ala Thr Ala
        515                 520                 525             
Ala Ala Ala Ala Thr Ala Phe Pro Gly Tyr Ala Val Pro Asn Ala Thr
    530                 535                 540                 
Ala Pro Val Ser Ala Ala Gln Leu Lys Gln Ala Val Thr Leu Gly Gln
545                 550                 555                 560 
Asp Leu Ala Ala Tyr Thr Thr Tyr Glu Val Tyr Pro Thr Phe Ala Val
                565                 570                 575     
Thr Ala Arg Gly Asp Gly Tyr Gly Thr Phe
            580                 585     


<210> 2008
<211> 240
<212> PRT
<213> Homo sapiens

<400> 2008
Met Ala Met Ala Thr Lys Gly Gly Thr Val Lys Ala Ala Ser Gly Phe
 1               5                  10                  15      
Asn Ala Met Glu Asp Ala Gln Thr Leu Arg Lys Ala Met Lys Gly Leu
            20                  25                  30          
Gly Thr Asp Glu Asp Ala Ile Ile Ser Val Leu Ala Tyr Arg Asn Thr
        35                  40                  45              
Ala Gln Arg Gln Glu Ile Arg Thr Ala Tyr Lys Ser Thr Ile Gly Arg
    50                  55                  60                  
Asp Leu Ile Asp Asp Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Gln
65                  70                  75                  80  
Val Ile Val Gly Met Met Thr Pro Thr Val Leu Tyr Asp Val Gln Glu
                85                  90                  95      
Leu Arg Arg Ala Met Lys Gly Ala Gly Thr Asp Glu Gly Cys Leu Ile
            100                 105                 110         
Glu Ile Leu Ala Ser Arg Thr Pro Glu Glu Ile Arg Arg Ile Ser Gln
        115                 120                 125             
Thr Tyr Gln Gln Gln Tyr Gly Arg Ser Leu Glu Asp Asp Ile Arg Ser
    130                 135                 140                 
Asp Thr Ser Phe Met Phe Gln Arg Val Leu Val Ser Leu Ser Ala Gly
145                 150                 155                 160 
Gly Arg Asp Glu Gly Asn Tyr Leu Asp Asp Ala Leu Val Arg Gln Asp
                165                 170                 175     
Ala Gln Asp Leu Tyr Glu Ala Gly Glu Lys Lys Trp Gly Thr Asp Glu
            180                 185                 190         
Val Lys Phe Leu Thr Val Leu Cys Ser Arg Asn Arg Asn His Leu Leu
        195                 200                 205             
His Gly Leu Met Asn Thr Lys Gly Tyr His Arg Arg Ile Leu Asn Arg
    210                 215                 220                 
Val Leu Asn Leu Lys His Leu Val Ala Leu Lys Met Leu Cys Trp Leu
225                 230                 235                 240 


<210> 2009
<211> 158
<212> PRT
<213> Homo sapiens

<400> 2009
Met Ala Ala Arg Ser Val Ser Gly Ile Thr Arg Arg Val Phe Met Trp
 1               5                  10                  15      
Thr Val Ser Gly Thr Pro Cys Arg Glu Phe Trp Ser Arg Phe Arg Lys
            20                  25                  30          
Glu Lys Glu Pro Val Val Val Glu Thr Val Glu Glu Lys Lys Glu Pro
        35                  40                  45              
Ile Leu Val Cys Pro Pro Leu Arg Ser Arg Ala Tyr Thr Pro Pro Glu
    50                  55                  60                  
Asp Leu Gln Ser Arg Leu Glu Ser Tyr Val Lys Glu Val Phe Gly Ser
65                  70                  75                  80  
Ser Leu Pro Ser Asn Trp Gln Asp Ile Ser Leu Glu Asp Ser Arg Leu
                85                  90                  95      
Lys Phe Asn Leu Leu Ala His Leu Ala Asp Asp Leu Gly His Val Val
            100                 105                 110         
Pro Asn Ser Arg Leu His Gln Met Cys Arg Val Arg Asp Val Leu Asp
        115                 120                 125             
Phe Tyr Asn Val Pro Ile Gln Asp Arg Ser Lys Phe Asp Glu Leu Ser
    130                 135                 140                 
Ala Ser Asn Leu Pro Pro Asn Leu Lys Ile Thr Trp Ser Tyr
145                 150                 155             


<210> 2010
<211> 400
<212> PRT
<213> Homo sapiens

<400> 2010
Met Ser Pro Pro Arg Leu Gly Ala Trp Thr His Ala Arg Arg Cys Pro
 1               5                  10                  15      
Ala Pro Thr Gln Pro Val Pro Phe Met Arg Gly Leu Glu Thr Cys Arg
            20                  25                  30          
Asn Gly Pro Ser Pro Lys Met Gly Leu Asn Ile Lys Ser Phe Phe His
        35                  40                  45              
Pro Arg Trp Gly Glu Asn Leu Lys Val Leu Ser Thr Arg Arg Met Thr
    50                  55                  60                  
Thr Thr Phe Leu Leu Leu Val Ser Gln Gly Ala Gln Pro His Ser Gly
65                  70                  75                  80  
Asp Ile Gly Ile Pro Phe Pro Arg Gly Ala Arg Pro Thr Gly Gly Gly
                85                  90                  95      
Phe Ser Gly Cys Thr Gly Pro Glu Glu Ala Gly Glu Glu Glu Ala Pro
            100                 105                 110         
Glu Ala Glu Lys Glu Pro Arg Val Gly Gly Gly Arg Arg Arg Arg Gln
        115                 120                 125             
Ala Val Leu Leu His Val Gln Gly Leu Pro Val Pro Ala Leu Glu Gly
    130                 135                 140                 
Glu Arg Leu Phe Gln Asn Ala Glu Pro Ala Pro Ala Glu Gly Asp Glu
145                 150                 155                 160 
Gly Leu Pro Asp Arg Gln Gln Ala Arg Gly Ala Leu Pro Arg Glu Ala
                165                 170                 175     
Gly Gly Arg Ala Glu Gln Gly Thr Ala Ala Val Pro Ala Ala Glu Pro
            180                 185                 190         
Arg Ala Arg Ala Asp Ala Gly Arg His Arg Gly Ala Leu Phe Cys Ala
        195                 200                 205             
Gly Leu Ala Ala Pro Gly Ala Arg Arg Ala Pro Glu Pro Ala Ala Pro
    210                 215                 220                 
Pro Arg Pro Ala His Cys Ala Val Val Met Ser Ala Gly Ala Ile Leu
225                 230                 235                 240 
Asn Ser Ser Leu Gly Glu Glu Ile Asp Ser His Asp Ala Val Leu Arg
                245                 250                 255     
Phe Asn Ser Ala Pro Thr Arg Gly Tyr Glu Lys Asp Val Gly Asn Lys
            260                 265                 270         
Thr Thr Ile Arg Ile Ile Asn Ser Gln Ile Leu Thr Asn Pro Ser His
        275                 280                 285             
His Phe Ile Asp Ser Ser Leu Tyr Lys Asp Val Ile Leu Val Ala Trp
    290                 295                 300                 
Asp Pro Ala Pro Tyr Ser Ala Asn Leu Asn Leu Trp Tyr Lys Lys Pro
305                 310                 315                 320 
Asp Tyr Asn Leu Phe Thr Pro Tyr Ile Gln His Arg Gln Arg Asn Pro
                325                 330                 335     
Asn Gln Pro Phe Tyr Ile Leu His Pro Lys Phe Ile Trp Gln Leu Trp
            340                 345                 350         
Asp Ile Ile Gln Glu Asn Thr Lys Glu Lys Ile Gln Pro Asn Pro Pro
        355                 360                 365             
Ser Ser Gly Phe Ile Gly Ser Phe Val Lys Ile Gly His Ile Arg Ala
    370                 375                 380                 
Cys Ser Glu Pro Arg Ser Arg Asp Cys Thr Pro Ala Trp Thr Thr Glu
385                 390                 395                 400 


<210> 2011
<211> 153
<212> PRT
<213> Homo sapiens

<400> 2011
Met Glu Cys Gln Leu His Lys Ser Arg Gly Gln Val Gly Leu Cys Pro
 1               5                  10                  15      
Asn Phe Pro Glu Pro Thr Val Pro Lys Trp Asp Ser Arg Val Gly Gly
            20                  25                  30          
Leu Cys Asp Phe Cys Ser Pro Thr Ser Phe Ser Thr Arg Pro Pro Met
        35                  40                  45              
Val Pro Pro Trp Leu Trp Glu Ala Gly Ile Arg Glu Arg Gly Ser Met
    50                  55                  60                  
Pro Val Ser Arg Thr Leu Pro Thr Leu Ala Trp Trp Gln Thr Trp Leu
65                  70                  75                  80  
Pro Arg Ala Glu Leu Pro Val Pro Leu Thr Pro Gln Arg Ser Gly His
                85                  90                  95      
Phe Leu His Val Ser Pro Ala His Val Asn Cys Arg Gln Asn Gln Gly
            100                 105                 110         
Ser Leu Arg Ala Ala Trp Gly Arg His Gln Thr Pro Gly Val Pro Ser
        115                 120                 125             
Trp Asp Pro Thr His Pro Thr Leu Lys Pro Gly Trp Gly Leu Glu Gln
    130                 135                 140                 
Gly Val Trp Phe Leu Gly Ala Gly Ser
145                 150             


<210> 2012
<211> 361
<212> PRT
<213> Homo sapiens

<400> 2012
Met Trp Val Leu Thr Pro Ala Ala Phe Ala Gly Lys Leu Leu Ser Val
 1               5                  10                  15      
Phe Arg Gln Pro Leu Ser Ser Leu Trp Arg Ser Leu Val Pro Leu Phe
            20                  25                  30          
Cys Trp Leu Arg Ala Thr Phe Trp Leu Leu Ala Thr Lys Arg Arg Lys
        35                  40                  45              
Gln Gln Leu Val Leu Arg Gly Pro Asp Glu Thr Lys Glu Glu Glu Glu
    50                  55                  60                  
Asp Pro Pro Leu Pro Thr Thr Pro Thr Ser Val Asn Tyr His Phe Thr
65                  70                  75                  80  
Arg Gln Cys Asn Tyr Lys Cys Gly Phe Cys Phe His Thr Ala Lys Thr
                85                  90                  95      
Ser Phe Val Leu Pro Leu Glu Glu Ala Lys Arg Gly Leu Leu Leu Leu
            100                 105                 110         
Lys Glu Ala Gly Met Glu Lys Ile Asn Phe Ser Gly Gly Glu Pro Phe
        115                 120                 125             
Leu Gln Asp Arg Gly Glu Tyr Leu Gly Lys Leu Val Arg Phe Cys Lys
    130                 135                 140                 
Val Glu Leu Arg Leu Pro Ser Val Ser Ile Val Ser Asn Gly Ser Leu
145                 150                 155                 160 
Ile Arg Glu Arg Trp Phe Gln Asn Tyr Gly Glu Tyr Leu Asp Ile Leu
                165                 170                 175     
Ala Ile Ser Cys Asp Ser Phe Asp Glu Glu Val Asn Val Leu Ile Gly
            180                 185                 190         
Arg Gly Gln Gly Lys Lys Asn His Val Glu Asn Leu Gln Lys Leu Arg
        195                 200                 205             
Arg Trp Cys Arg Asp Tyr Arg Val Ala Phe Lys Ile Asn Ser Val Ile
    210                 215                 220                 
Asn Arg Phe Asn Val Glu Glu Asp Met Thr Glu Gln Ile Lys Ala Leu
225                 230                 235                 240 
Asn Pro Val Arg Trp Lys Val Phe Gln Cys Leu Leu Ile Glu Gly Glu
                245                 250                 255     
Asn Cys Gly Glu Asp Ala Leu Arg Glu Ala Glu Arg Phe Val Ile Gly
            260                 265                 270         
Asp Glu Glu Phe Glu Arg Phe Leu Glu Arg His Lys Glu Val Ser Cys
        275                 280                 285             
Leu Val Pro Glu Ser Asn Gln Lys Met Lys Asp Ser Tyr Leu Ile Leu
    290                 295                 300                 
Asp Glu Tyr Met Arg Phe Leu Asn Cys Arg Lys Gly Arg Lys Asp Pro
305                 310                 315                 320 
Ser Lys Ser Ile Leu Asp Val Gly Val Glu Glu Ala Ile Lys Phe Ser
                325                 330                 335     
Gly Phe Asp Glu Lys Met Phe Leu Lys Arg Gly Gly Lys Tyr Ile Trp
            340                 345                 350         
Ser Lys Ala Asp Leu Lys Leu Asp Trp
        355                 360     


<210> 2013
<211> 371
<212> PRT
<213> Homo sapiens

<400> 2013
Met Leu Gln Cys Tyr Arg Cys Arg Gln Trp Phe His Glu Ala Cys Thr
 1               5                  10                  15      
Gln Cys Leu Asn Glu Pro Met Met Phe Gly Asp Arg Phe Tyr Leu Phe
            20                  25                  30          
Phe Cys Ser Val Cys Asn Gln Gly Pro Glu Tyr Ile Glu Arg Leu Pro
        35                  40                  45              
Leu Arg Trp Val Asp Val Val His Leu Ala Leu Tyr Asn Leu Gly Val
    50                  55                  60                  
Gln Ser Lys Lys Lys Tyr Phe Asp Phe Glu Glu Ile Leu Ala Phe Val
65                  70                  75                  80  
Asn His His Trp Glu Leu Leu Gln Leu Gly Lys Leu Thr Ser Thr Pro
                85                  90                  95      
Val Thr Asp Arg Gly Pro His Leu Leu Asn Ala Leu Asn Ser Tyr Lys
            100                 105                 110         
Ser Arg Phe Leu Cys Gly Lys Glu Ile Lys Lys Lys Lys Cys Ile Phe
        115                 120                 125             
Arg Leu Arg Ile Arg Val Pro Pro Asn Pro Pro Gly Lys Leu Leu Pro
    130                 135                 140                 
Asp Lys Gly Leu Leu Pro Asn Glu Asn Ser Ala Ser Ser Glu Leu Arg
145                 150                 155                 160 
Lys Arg Gly Lys Ser Lys Pro Gly Leu Leu Pro His Glu Phe Gln Gln
                165                 170                 175     
Gln Lys Arg Arg Val Tyr Arg Arg Lys Arg Ser Lys Phe Leu Leu Glu
            180                 185                 190         
Asp Ala Ile Pro Ser Ser Asp Phe Thr Ser Ala Trp Ser Thr Asn His
        195                 200                 205             
His Leu Ala Ser Ile Phe Asp Phe Thr Leu Asp Glu Ile Gln Ser Leu
    210                 215                 220                 
Lys Ser Ala Ser Ser Gly Gln Thr Phe Phe Ser Asp Val Asp Ser Thr
225                 230                 235                 240 
Asp Ala Ala Ser Thr Ser Gly Ser Ala Ser Thr Ser Leu Ser Tyr Asp
                245                 250                 255     
Ser Arg Trp Thr Val Gly Ser Arg Lys Arg Lys Leu Ala Ala Lys Ala
            260                 265                 270         
Tyr Met Pro Leu Arg Ala Lys Arg Trp Ala Ala Glu Leu Asp Gly Arg
        275                 280                 285             
Cys Pro Ser Asp Ser Ser Ala Glu Gly Ala Ser Val Pro Glu Arg Pro
    290                 295                 300                 
Asp Glu Gly Ile Asp Ser His Thr Phe Glu Ser Ile Ser Glu Asp Asp
305                 310                 315                 320 
Ser Ser Leu Ser His Leu Lys Ser Ser Ile Thr Asn Tyr Phe Gly Ala
                325                 330                 335     
Ala Gly Arg Leu Ala Cys Gly Glu Lys Tyr Gln Val Leu Ala Arg Arg
            340                 345                 350         
Val Thr Pro Glu Gly Lys Val Gln Tyr Leu Val Glu Trp Glu Gly Thr
        355                 360                 365             
Thr Pro Tyr
    370     


<210> 2014
<211> 370
<212> PRT
<213> Homo sapiens

<400> 2014
Met Pro Thr Glu Thr Leu Gln Thr Gly Ser Met Val Lys Pro Val Ser
 1               5                  10                  15      
Pro Ala Gly Thr Phe Thr Ser Ala Val Pro Leu Arg Ile Leu Asn Lys
            20                  25                  30          
Gly Pro Asp Tyr Phe Arg Arg Gln Ala Glu Pro Asn Pro Lys Arg Leu
        35                  40                  45              
Thr Ala Val Glu Arg Leu Glu Ala Asp Lys Ala Lys Tyr Val Lys Ser
    50                  55                  60                  
Gln Glu Val Ile Asn Ala Lys Gln Glu Pro Val Lys Pro Ala Val Leu
65                  70                  75                  80  
Ala Lys Pro Pro Val Cys Pro Ala Ala Lys Arg Ala Leu Gly Ser Pro
                85                  90                  95      
Thr Leu Lys Val Phe Gly Asn His Ala Lys Thr Glu Ser Gly Val Gln
            100                 105                 110         
Arg Glu Asn Leu Lys Leu Glu Ile Leu Lys Asn Ile Ile Asn Ser Ser
        115                 120                 125             
Glu Gly Ser Ser Ser Gly Ser Gly His Lys His Ser Ser Arg Asn Trp
    130                 135                 140                 
Pro Pro His Arg Ser Glu Ala Thr Asp Leu His Arg His Ser Phe Ala
145                 150                 155                 160 
Glu Ser Leu Lys Val Tyr Pro Thr Gln Gly Arg Arg Ser Pro Gln Glu
                165                 170                 175     
Gly Gly Ser His Val Gly Arg Arg Leu Leu Glu Gln Ser Ala Glu Ser
            180                 185                 190         
Phe Leu His Val Ser His Ser Ser Ser Asp Ile Arg Lys Val Thr Ser
        195                 200                 205             
Val Lys Pro Leu Lys Ala Ile Pro Cys Ser Ser Ser Ala Pro Pro Leu
    210                 215                 220                 
Pro Pro Lys Pro Lys Ile Ala Ala Ile Ala Ser Met Lys Ser Pro Glu
225                 230                 235                 240 
Ala Asp Pro Val Glu Pro Ala Cys Gly Val Ser Arg Arg Pro Ser Leu
                245                 250                 255     
Gln Arg Ser Lys Ser Asp Leu Ser Asp Arg Tyr Phe Arg Val Asp Ala
            260                 265                 270         
Asp Val Glu Arg Phe Phe Asn Tyr Cys Gly Leu Asp Pro Glu Glu Leu
        275                 280                 285             
Glu Asn Leu Gly Met Glu Asn Phe Ala Arg Ala Asn Ser Asp Ile Ile
    290                 295                 300                 
Ser Leu Asn Phe Arg Ser Ala Ser Met Ile Ser Ser Asp Cys Glu Gln
305                 310                 315                 320 
Ser Gln Asp Ser Asn Ser Asp Leu Arg Asn Asp Asp Ser Ala Asn Asp
                325                 330                 335     
Arg Val Pro Tyr Gly Ile Ser Ala Ile Glu Arg Asn Ala Arg Ile Ile
            340                 345                 350         
Lys Trp Leu Tyr Ser Ile Lys Gln Ala Arg Glu Ser Gln Lys Val Ser
        355                 360                 365             
His Val
    370 


<210> 2015
<211> 523
<212> PRT
<213> Homo sapiens

<400> 2015
Met Thr Val Val Pro Gly Asp His Leu Leu Glu Pro Glu Val Ala Asp
 1               5                  10                  15      
Gly Gly Gly Ala Pro Pro Gln Gly Gly Cys Gly Gly Gly Gly Cys Asp
            20                  25                  30          
Arg Tyr Glu Pro Leu Pro Pro Ser Leu Pro Ala Ala Gly Glu Gln Asp
        35                  40                  45              
Cys Cys Gly Glu Arg Val Val Ile Asn Ile Ser Gly Leu Arg Phe Glu
    50                  55                  60                  
Thr Gln Leu Lys Thr Leu Cys Gln Phe Pro Glu Thr Leu Leu Gly Asp
65                  70                  75                  80  
Pro Lys Arg Arg Met Arg Tyr Phe Asp Pro Leu Arg Asn Glu Tyr Phe
                85                  90                  95      
Phe Asp Arg Asn Arg Pro Ser Phe Asp Ala Ile Leu Tyr Tyr Tyr Gln
            100                 105                 110         
Ser Gly Gly Arg Ile Arg Arg Pro Val Asn Val Pro Ile Asp Ile Phe
        115                 120                 125             
Ser Glu Glu Ile Arg Phe Tyr Gln Leu Gly Glu Glu Ala Met Glu Lys
    130                 135                 140                 
Phe Arg Glu Asp Glu Gly Phe Leu Arg Glu Glu Glu Arg Pro Leu Pro
145                 150                 155                 160 
Arg Arg Asp Phe Gln Arg Gln Val Trp Leu Leu Phe Glu Tyr Pro Glu
                165                 170                 175     
Ser Ser Gly Pro Ala Arg Gly Ile Ala Ile Val Ser Val Leu Val Ile
            180                 185                 190         
Leu Ile Ser Ile Val Ile Phe Cys Leu Glu Thr Leu Pro Glu Phe Arg
        195                 200                 205             
Asp Glu Lys Asp Tyr Pro Ala Ser Thr Ser Gln Asp Ser Phe Glu Ala
    210                 215                 220                 
Ala Gly Asn Ser Thr Ser Gly Ser Arg Ala Gly Ala Ser Ser Phe Ser
225                 230                 235                 240 
Asp Pro Phe Phe Val Val Glu Thr Leu Cys Ile Ile Trp Phe Ser Phe
                245                 250                 255     
Glu Leu Leu Val Arg Phe Phe Ala Cys Pro Ser Lys Ala Thr Phe Ser
            260                 265                 270         
Arg Asn Ile Met Asn Leu Ile Asp Ile Val Ala Ile Ile Pro Tyr Phe
        275                 280                 285             
Ile Thr Leu Gly Thr Glu Leu Ala Glu Arg Gln Gly Asn Gly Gln Gln
    290                 295                 300                 
Ala Met Ser Leu Ala Ile Leu Arg Val Ile Arg Leu Val Arg Val Phe
305                 310                 315                 320 
Arg Ile Phe Lys Leu Ser Arg His Ser Lys Gly Leu Gln Ile Leu Gly
                325                 330                 335     
Gln Thr Leu Lys Ala Ser Met Arg Glu Leu Gly Leu Leu Ile Phe Phe
            340                 345                 350         
Leu Phe Ile Gly Val Ile Leu Phe Ser Ser Ala Val Tyr Phe Ala Glu
        355                 360                 365             
Ala Asp Asp Pro Thr Ser Gly Phe Ser Ser Ile Pro Asp Ala Phe Trp
    370                 375                 380                 
Trp Ala Val Val Thr Met Thr Thr Val Gly Tyr Gly Asp Met His Pro
385                 390                 395                 400 
Val Thr Ile Gly Gly Lys Ile Val Gly Ser Leu Cys Ala Ile Ala Gly
                405                 410                 415     
Val Leu Thr Ile Ala Leu Pro Val Pro Val Ile Val Ser Asn Phe Asn
            420                 425                 430         
Tyr Phe Tyr His Arg Glu Thr Glu Gly Glu Glu Gln Ser Gln Tyr Met
        435                 440                 445             
His Val Gly Ser Cys Gln His Leu Ser Ser Ser Ala Glu Glu Leu Arg
    450                 455                 460                 
Lys Ala Arg Ser Asn Ser Thr Leu Ser Lys Ser Glu Tyr Met Val Ile
465                 470                 475                 480 
Glu Glu Gly Gly Met Asn His Ser Ala Phe Pro Gln Thr Pro Phe Lys
                485                 490                 495     
Thr Gly Asn Ser Thr Ala Thr Cys Thr Thr Asn Asn Asn Pro Asn Ser
            500                 505                 510         
Cys Val Asn Ile Lys Lys Ile Phe Thr Asp Val
        515                 520             


<210> 2016
<211> 588
<212> PRT
<213> Homo sapiens

<400> 2016
Met Val Glu Leu Pro Leu Arg His Pro Ala Leu Phe Lys Ala Ile Gly
 1               5                  10                  15      
Val Lys Pro Pro Arg Gly Ile Leu Leu Tyr Gly Pro Pro Gly Thr Gly
            20                  25                  30          
Lys Thr Leu Ile Ala Arg Ala Val Ala Asn Glu Thr Gly Ala Phe Phe
        35                  40                  45              
Phe Leu Ile Asn Gly Pro Glu Ile Met Ser Lys Leu Ala Gly Glu Ser
    50                  55                  60                  
Glu Ser Asn Leu Arg Lys Ala Phe Glu Glu Ala Glu Lys Asn Ala Pro
65                  70                  75                  80  
Ala Ile Ile Phe Ile Asp Glu Leu Asp Ala Ile Ala Pro Lys Arg Glu
                85                  90                  95      
Lys Thr His Gly Glu Val Glu Arg Arg Ile Val Ser Gln Leu Leu Thr
            100                 105                 110         
Leu Met Asp Gly Leu Lys Gln Arg Ala His Val Ile Val Met Ala Ala
        115                 120                 125             
Thr Asn Arg Pro Asn Ser Ile Asp Pro Ala Leu Arg Arg Phe Gly Arg
    130                 135                 140                 
Phe Asp Arg Glu Val Asp Ile Gly Ile Pro Asp Ala Thr Gly Arg Leu
145                 150                 155                 160 
Glu Ile Leu Gln Ile His Thr Lys Asn Met Lys Leu Ala Asp Asp Val
                165                 170                 175     
Asp Leu Glu Gln Val Ala Asn Glu Thr His Gly His Val Gly Ala Asp
            180                 185                 190         
Leu Ala Ala Leu Cys Ser Glu Ala Ala Leu Gln Ala Ile Arg Lys Lys
        195                 200                 205             
Met Asp Leu Ile Asp Leu Glu Asp Glu Thr Ile Asp Ala Glu Val Met
    210                 215                 220                 
Asn Ser Leu Ala Val Thr Met Asp Asp Phe Arg Trp Ala Leu Ser Gln
225                 230                 235                 240 
Ser Asn Pro Ser Ala Leu Arg Glu Thr Val Val Glu Val Pro Gln Val
                245                 250                 255     
Thr Trp Glu Asp Ile Gly Gly Leu Glu Asp Val Lys Arg Glu Leu Gln
            260                 265                 270         
Glu Leu Val Gln Tyr Pro Val Glu His Pro Asp Lys Phe Leu Lys Phe
        275                 280                 285             
Gly Met Thr Pro Ser Lys Gly Val Leu Phe Tyr Gly Pro Pro Gly Cys
    290                 295                 300                 
Gly Lys Thr Leu Leu Ala Lys Ala Ile Ala Asn Glu Cys Gln Ala Asn
305                 310                 315                 320 
Phe Ile Ser Ile Lys Gly Pro Glu Leu Leu Thr Met Trp Phe Gly Glu
                325                 330                 335     
Ser Glu Ala Asn Val Arg Glu Ile Phe Asp Lys Ala Arg Gln Ala Ala
            340                 345                 350         
Pro Cys Val Leu Phe Phe Asp Glu Leu Asp Ser Ile Ala Lys Ala Arg
        355                 360                 365             
Gly Gly Asn Ile Gly Asp Gly Gly Gly Ala Ala Asp Arg Val Ile Asn
    370                 375                 380                 
Gln Ile Leu Thr Glu Met Asp Gly Met Ser Thr Lys Lys Asn Val Phe
385                 390                 395                 400 
Ile Ile Gly Ala Thr Asn Arg Pro Asp Ile Ile Asp Pro Ala Ile Leu
                405                 410                 415     
Arg Pro Gly Arg Leu Asp Gln Leu Ile Tyr Ile Pro Leu Pro Asp Glu
            420                 425                 430         
Lys Ser Arg Val Ala Ile Leu Lys Ala Asn Leu Arg Lys Ser Pro Val
        435                 440                 445             
Ala Lys Asp Val Asp Leu Glu Phe Leu Ala Lys Met Thr Asn Gly Phe
    450                 455                 460                 
Ser Gly Ala Asp Leu Thr Glu Ile Cys Gln Arg Ala Cys Lys Leu Ala
465                 470                 475                 480 
Ile Arg Glu Ser Ile Glu Ser Glu Ile Arg Arg Glu Arg Glu Arg Gln
                485                 490                 495     
Thr Asn Pro Ser Ala Met Glu Val Glu Glu Asp Asp Pro Val Pro Glu
            500                 505                 510         
Ile Arg Arg Asp His Phe Glu Glu Ala Met Arg Phe Ala Arg Arg Ser
        515                 520                 525             
Val Ser Asp Asn Asp Ile Arg Lys Tyr Glu Met Phe Ala Gln Thr Leu
    530                 535                 540                 
Gln Gln Ser Arg Gly Phe Gly Ser Phe Arg Phe Pro Ser Gly Asn Gln
545                 550                 555                 560 
Gly Gly Ala Gly Pro Ser Gln Gly Ser Gly Gly Gly Thr Gly Gly Ser
                565                 570                 575     
Val Tyr Thr Glu Asp Asn Asp Asp Asp Leu Tyr Gly
            580                 585             


<210> 2017
<211> 186
<212> PRT
<213> Homo sapiens

<400> 2017
Met Thr Glu Arg Arg Val Pro Phe Ser Leu Leu Arg Gly Pro Ser Trp
 1               5                  10                  15      
Asp Pro Phe Arg Asp Trp Tyr Pro His Ser Arg Leu Phe Asp Gln Ala
            20                  25                  30          
Phe Gly Leu Pro Arg Leu Pro Glu Glu Trp Ser Gln Trp Leu Gly Gly
        35                  40                  45              
Ser Ser Trp Pro Gly Tyr Val Arg Pro Leu Pro Pro Ala Ala Ile Glu
    50                  55                  60                  
Ser Pro Ala Val Ala Ala Pro Ala Tyr Ser Arg Ala Leu Ser Arg Gln
65                  70                  75                  80  
Leu Ser Ser Gly Val Ser Glu Ile Arg His Thr Ala Asp Arg Trp Arg
                85                  90                  95      
Val Ser Leu Asp Val Asn His Phe Ala Pro Asp Glu Leu Thr Val Lys
            100                 105                 110         
Thr Lys Asp Gly Val Val Glu Ile Thr Gly Glu Pro Pro Cys Ser Cys
        115                 120                 125             
Arg Gly Glu Glu Glu Ala Ser Arg Ala Gly Arg Ala Gly Gly Val Arg
    130                 135                 140                 
Leu Lys Arg Gly Ser Arg Gly Pro Gly Glu Leu Asn Val Gly Pro Ala
145                 150                 155                 160 
Pro Gly Lys Thr Gly Leu Leu Ile Pro Leu Leu Arg Asn Trp Glu Cys
                165                 170                 175     
Gly Ser Leu Leu Arg Ala Leu Ser Ala Leu
            180                 185     


<210> 2018
<211> 913
<212> PRT
<213> Homo sapiens

<400> 2018
Met Thr Ile Lys Lys Pro Pro Gln Leu Ser Glu Asp Asp Ile Trp Leu
 1               5                  10                  15      
Lys Ser Glu Gly Asp Asn Tyr Ser Ala Thr Leu Leu Glu Pro Ala Ala
            20                  25                  30          
Ser Ser Leu Ser Pro Asp His Lys Asn Met Glu Ile Glu Val Ser Val
        35                  40                  45              
Ala Glu Cys Lys Ser Val Pro Gly Ile Thr Ser Thr Pro His Pro Met
    50                  55                  60                  
Asp His Pro Ser Ala Phe Tyr Ser Pro Pro His Asn Gly Leu Leu Thr
65                  70                  75                  80  
Asp His His Glu Ser Leu Asp Asn Asp Val Ala Arg Glu Ile Arg Tyr
                85                  90                  95      
Leu Asp Glu Val Leu Glu Ala Asn Cys Cys Asp Ser Ala Val Asp Gly
            100                 105                 110         
Thr Tyr Asn Gly Thr Ser Ser Pro Glu Pro Gly Ala Val Val Leu Val
        115                 120                 125             
Gly Gly Leu Ser Pro Pro Val His Glu Ala Thr Gln Pro Glu Pro Thr
    130                 135                 140                 
Glu Arg Thr Ala Ser Arg Gln Ala Pro Pro His Ile Glu Leu Ser Asn
145                 150                 155                 160 
Ser Ser Pro Asp Pro Met Ala Glu Ala Glu Arg Thr Asn Gly His Ser
                165                 170                 175     
Pro Ser Gln Pro Arg Asp Ala Leu Gly Asp Ser Leu Gln Val Pro Val
            180                 185                 190         
Ser Pro Ser Ser Thr Thr Ser Ser Arg Cys Ser Ser Arg Asp Gly Glu
        195                 200                 205             
Phe Thr Leu Thr Thr Leu Lys Lys Glu Ala Lys Phe Glu Leu Arg Ala
    210                 215                 220                 
Phe His Glu Asp Lys Lys Pro Ser Lys Leu Phe Glu Asp Asp Glu His
225                 230                 235                 240 
Glu Lys Glu Gln Tyr Cys Ile Arg Lys Val Arg Pro Ser Glu Glu Met
                245                 250                 255     
Leu Glu Leu Glu Lys Glu Arg Arg Glu Leu Ile Arg Ser Gln Ala Val
            260                 265                 270         
Lys Lys Asn Pro Gly Ile Ala Ala Lys Trp Trp Asn Pro Pro Gln Glu
        275                 280                 285             
Lys Thr Ile Glu Glu Gln Leu Asp Glu Glu His Leu Glu Ser His Lys
    290                 295                 300                 
Lys Tyr Lys Glu Arg Lys Glu Arg Arg Ala Gln Gln Glu Gln Leu Leu
305                 310                 315                 320 
Leu Gln Lys Gln Leu Gln Gln Gln Gln Gln Gln Pro Pro Ser Gln Leu
                325                 330                 335     
Cys Thr Ala Pro Ala Ser Ser His Glu Arg Ala Ser Met Ile Asp Lys
            340                 345                 350         
Ala Lys Glu Asp Ile Val Thr Glu Gln Ile Asp Phe Ser Ala Ala Arg
        355                 360                 365             
Lys Gln Phe Gln Leu Met Glu Asn Ser Arg Gln Ala Val Ala Lys Gly
    370                 375                 380                 
Gln Ser Thr Pro Arg Leu Phe Ser Ile Lys Pro Phe Tyr Arg Pro Leu
385                 390                 395                 400 
Gly Ser Val Asn Ser Asp Lys Pro Leu Thr Asn Pro Arg Pro Pro Ser
                405                 410                 415     
Val Gly Gly Pro Pro Glu Asp Ser Gly Ala Ser Ala Ala Lys Gly Gln
            420                 425                 430         
Lys Ser Pro Gly Ala Leu Glu Thr Pro Ser Ala Ala Gly Ser Gln Gly
        435                 440                 445             
Asn Thr Ala Ser Gln Gly Lys Glu Gly Pro Tyr Ser Glu Pro Ser Lys
    450                 455                 460                 
Arg Gly Pro Leu Ser Lys Leu Trp Ala Glu Asp Gly Glu Phe Thr Ser
465                 470                 475                 480 
Ala Arg Ala Val Leu Thr Val Val Lys Asp Asp Asp His Gly Ile Leu
                485                 490                 495     
Asp Gln Phe Ser Arg Ser Val Asn Val Ser Leu Thr Gln Glu Glu Leu
            500                 505                 510         
Asp Ser Gly Leu Asp Glu Leu Ser Val Arg Ser Gln Asp Thr Thr Val
        515                 520                 525             
Leu Glu Thr Leu Ser Asn Asp Phe Ser Met Asp Asn Ile Ser Asp Ser
    530                 535                 540                 
Gly Ala Ser Asn Glu Thr Thr Asn Ala Leu Gln Glu Asn Ser Leu Ala
545                 550                 555                 560 
Asp Phe Ser Leu Pro Gln Thr Pro Gln Thr Asp Asn Pro Ser Glu Gly
                565                 570                 575     
Arg Gly Glu Gly Val Ser Lys Ser Phe Ser Asp His Gly Phe Tyr Ser
            580                 585                 590         
Pro Ser Ser Thr Leu Gly Asp Ser Pro Leu Val Asp Asp Pro Leu Glu
        595                 600                 605             
Tyr Gln Ala Gly Leu Leu Val Gln Asn Ala Ile Gln Gln Ala Ile Ala
    610                 615                 620                 
Glu Gln Val Asp Lys Ala Val Ser Lys Thr Ser Arg Asp Gly Ala Glu
625                 630                 635                 640 
Gln Gln Gly Pro Glu Ala Thr Val Glu Glu Ala Glu Ala Ala Ala Phe
                645                 650                 655     
Gly Ser Glu Lys Pro Gln Ser Met Phe Glu Pro Pro Gln Val Ser Ser
            660                 665                 670         
Pro Val Gln Glu Lys Arg Asp Val Leu Pro Lys Ile Leu Pro Ala Glu
        675                 680                 685             
Asp Arg Ala Leu Arg Glu Arg Gly Pro Pro Gln Pro Leu Pro Ala Val
    690                 695                 700                 
Gln Pro Ser Gly Pro Ile Asn Met Glu Glu Thr Arg Pro Glu Gly Ser
705                 710                 715                 720 
Tyr Phe Ser Lys Tyr Ser Glu Ala Ala Glu Leu Arg Ser Thr Ala Ser
                725                 730                 735     
Leu Leu Ala Thr Gln Glu Ser Asp Val Met Val Gly Pro Phe Lys Leu
            740                 745                 750         
Arg Ser Arg Lys Gln Arg Thr Leu Ser Met Ile Glu Glu Glu Ile Arg
        755                 760                 765             
Ala Ala Gln Glu Arg Glu Glu Glu Leu Lys Arg Gln Arg Gln Val Leu
    770                 775                 780                 
Gln Ser Thr Gln Ser Pro Arg Thr Lys Asn Ala Pro Ser Leu Pro Ser
785                 790                 795                 800 
Arg Thr Cys Tyr Lys Thr Ala Pro Gly Lys Ile Glu Lys Val Lys Pro
                805                 810                 815     
Pro Pro Ser Pro Thr Thr Glu Gly Pro Ser Leu Gln Pro Asp Leu Ala
            820                 825                 830         
Pro Glu Glu Ala Ala Gly Thr Gln Arg Pro Lys Asn Leu Met Gln Thr
        835                 840                 845             
Leu Met Glu Asp Tyr Glu Thr His Lys Ser Lys Arg Arg Glu Arg Met
    850                 855                 860                 
Asp Asp Ser Ser Tyr Thr Ser Lys Leu Leu Ser Cys Lys Val Thr Ser
865                 870                 875                 880 
Glu Val Leu Glu Ala Thr Arg Val Asn Arg Arg Lys Ser Ala Leu Ala
                885                 890                 895     
Leu Arg Trp Glu Ala Gly Ile Tyr Ala Asn Gln Glu Glu Glu Asp Asn
            900                 905                 910         
Glu
    


<210> 2019
<211> 105
<212> PRT
<213> Homo sapiens

<400> 2019
Met Val Lys Gln Ile Glu Ser Lys Thr Ala Phe Gln Glu Ala Leu Asp
 1               5                  10                  15      
Ala Ala Gly Asp Lys Leu Val Val Val Asp Phe Ser Ala Thr Trp Cys
            20                  25                  30          
Gly Pro Cys Lys Met Ile Lys Pro Phe Phe His Ser Leu Ser Glu Lys
        35                  40                  45              
Tyr Ser Asn Val Ile Phe Leu Glu Val Asp Val Asp Asp Cys Gln Asp
    50                  55                  60                  
Val Ala Ser Glu Cys Glu Val Lys Cys Met Pro Thr Phe Gln Phe Phe
65                  70                  75                  80  
Lys Lys Gly Gln Lys Val Gly Glu Phe Ser Gly Ala Asn Lys Glu Lys
                85                  90                  95      
Leu Glu Ala Thr Ile Asn Glu Leu Val
            100                 105 


<210> 2020
<211> 1199
<212> PRT
<213> Homo sapiens

<400> 2020
Met Pro Leu Thr Gly Val Glu Pro Ala Arg Met Asn Arg Lys Lys Gly
 1               5                  10                  15      
Asp Lys Gly Phe Glu Ser Pro Arg Pro Tyr Lys Leu Thr His Gln Val
            20                  25                  30          
Val Cys Ile Asn Asn Ile Asn Phe Gln Arg Lys Ser Val Val Gly Phe
        35                  40                  45              
Val Glu Leu Thr Ile Phe Pro Thr Val Ala Asn Leu Asn Arg Ile Lys
    50                  55                  60                  
Leu Asn Ser Lys Gln Cys Arg Ile Tyr Arg Val Arg Ile Asn Asp Leu
65                  70                  75                  80  
Glu Ala Ala Phe Ile Tyr Asn Asp Pro Thr Leu Glu Val Cys His Ser
                85                  90                  95      
Glu Ser Lys Gln Arg Asn Leu Asn Tyr Phe Ser Asn Ala Tyr Ala Ala
            100                 105                 110         
Ala Val Ser Ala Val Asp Pro Asp Ala Gly Asn Gly Glu Leu Cys Ile
        115                 120                 125             
Lys Val Pro Ser Glu Leu Trp Lys His Val Asp Glu Leu Lys Val Leu
    130                 135                 140                 
Lys Ile His Ile Asn Phe Ser Leu Asp Gln Pro Lys Gly Gly Leu His
145                 150                 155                 160 
Phe Val Val Pro Ser Val Glu Gly Ser Met Ala Glu Arg Gly Ala His
                165                 170                 175     
Val Phe Ser Cys Gly Tyr Gln Asn Ser Thr Arg Phe Trp Phe Pro Cys
            180                 185                 190         
Val Asp Ser Tyr Ser Glu Leu Cys Thr Trp Lys Leu Glu Phe Thr Val
        195                 200                 205             
Asp Ala Ala Met Val Ala Val Ser Asn Gly Asp Leu Val Glu Thr Val
    210                 215                 220                 
Tyr Thr His Asp Met Arg Lys Lys Thr Phe His Tyr Met Leu Thr Ile
225                 230                 235                 240 
Pro Thr Ala Ala Ser Asn Ile Ser Leu Ala Ile Gly Pro Phe Glu Ile
                245                 250                 255     
Leu Val Asp Pro Tyr Met His Glu Val Thr His Phe Cys Leu Pro Gln
            260                 265                 270         
Leu Leu Pro Leu Leu Lys His Thr Thr Ser Tyr Leu His Glu Val Phe
        275                 280                 285             
Glu Phe Tyr Glu Glu Ile Leu Thr Cys Arg Tyr Pro Tyr Ser Cys Phe
    290                 295                 300                 
Lys Thr Val Phe Ile Asp Glu Ala Tyr Val Glu Val Ala Ala Tyr Ala
305                 310                 315                 320 
Ser Met Ser Ile Phe Ser Thr Asn Leu Leu His Ser Ala Met Ile Ile
                325                 330                 335     
Asp Glu Thr Pro Leu Thr Arg Arg Cys Leu Ala Gln Ser Leu Ala Gln
            340                 345                 350         
Gln Phe Phe Gly Cys Phe Ile Ser Arg Met Ser Trp Ser Asp Glu Trp
        355                 360                 365             
Val Leu Lys Gly Ile Ser Gly Tyr Ile Tyr Gly Leu Trp Met Lys Lys
    370                 375                 380                 
Thr Phe Gly Val Asn Glu Tyr Arg His Trp Ile Lys Glu Glu Leu Asp
385                 390                 395                 400 
Lys Ile Val Ala Tyr Glu Leu Lys Thr Gly Gly Val Leu Leu His Pro
                405                 410                 415     
Ile Phe Gly Gly Gly Lys Glu Lys Asp Asn Pro Ala Ser His Leu His
            420                 425                 430         
Phe Ser Ile Lys His Pro His Thr Leu Ser Trp Glu Tyr Tyr Ser Met
        435                 440                 445             
Phe Gln Cys Lys Ala His Leu Val Met Arg Leu Ile Glu Asn Arg Ile
    450                 455                 460                 
Ser Met Glu Phe Met Leu Gln Val Phe Asn Lys Leu Leu Ser Leu Ala
465                 470                 475                 480 
Ser Thr Ala Ser Ser Gln Lys Phe Gln Ser His Met Trp Ser Gln Met
                485                 490                 495     
Leu Val Ser Thr Ser Gly Phe Leu Lys Ser Ile Ser Asn Val Ser Gly
            500                 505                 510         
Lys Asp Ile Gln Pro Leu Ile Lys Gln Trp Val Asp Gln Ser Gly Val
        515                 520                 525             
Val Lys Phe Tyr Gly Ser Phe Ala Phe Asn Arg Lys Arg Asn Val Leu
    530                 535                 540                 
Glu Leu Glu Ile Lys Gln Asp Tyr Thr Ser Pro Gly Thr Gln Lys Tyr
545                 550                 555                 560 
Val Gly Pro Leu Lys Val Thr Val Gln Glu Leu Asp Gly Ser Phe Asn
                565                 570                 575     
His Thr Leu Gln Ile Glu Glu Asn Ser Leu Lys His Asp Ile Pro Cys
            580                 585                 590         
His Ser Lys Ser Arg Arg Asn Lys Lys Lys Lys Ile Pro Leu Met Asn
        595                 600                 605             
Gly Glu Glu Val Asp Met Asp Leu Ser Ala Met Asp Ala Asp Ser Pro
    610                 615                 620                 
Leu Leu Trp Ile Arg Ile Asp Pro Asp Met Ser Val Leu Arg Lys Val
625                 630                 635                 640 
Glu Phe Glu Gln Ala Asp Phe Met Trp Gln Tyr Gln Leu Arg Tyr Glu
                645                 650                 655     
Arg Asp Val Val Ala Gln Gln Glu Ser Ile Leu Ala Leu Glu Lys Phe
            660                 665                 670         
Pro Thr Pro Ala Ser Arg Leu Ala Leu Thr Asp Ile Leu Glu Gln Glu
        675                 680                 685             
Gln Cys Phe Tyr Arg Val Arg Met Ser Ala Cys Phe Cys Leu Ala Lys
    690                 695                 700                 
Ile Ala Asn Ser Met Val Ser Thr Trp Thr Gly Pro Pro Ala Met Lys
705                 710                 715                 720 
Ser Leu Phe Thr Arg Met Phe Cys Cys Lys Ser Cys Pro Asn Ile Val
                725                 730                 735     
Lys Thr Asn Asn Phe Met Ser Phe Gln Ser Tyr Phe Leu Gln Lys Thr
            740                 745                 750         
Met Pro Val Ala Met Ala Leu Leu Arg Asp Val His Asn Leu Cys Pro
        755                 760                 765             
Lys Glu Val Leu Thr Phe Ile Leu Asp Leu Ile Lys Tyr Asn Asp Asn
    770                 775                 780                 
Arg Lys Asn Lys Phe Ser Asp Asn Tyr Tyr Arg Ala Glu Met Ile Asp
785                 790                 795                 800 
Ala Leu Ala Asn Ser Val Thr Pro Ala Val Ser Val Asn Asn Glu Val
                805                 810                 815     
Arg Thr Leu Asp Asn Leu Asn Pro Asp Val Arg Leu Ile Leu Glu Glu
            820                 825                 830         
Ile Thr Arg Phe Leu Asn Met Glu Lys Leu Leu Pro Ser Tyr Arg His
        835                 840                 845             
Thr Ile Thr Val Ser Cys Leu Arg Ala Ile Arg Val Leu Gln Lys Asn
    850                 855                 860                 
Gly His Val Pro Ser Asp Pro Ala Leu Phe Lys Ser Tyr Ala Glu Tyr
865                 870                 875                 880 
Gly His Phe Val Asp Ile Arg Ile Ala Ala Leu Glu Ala Val Val Asp
                885                 890                 895     
Tyr Thr Lys Val Asp Arg Ser Tyr Glu Glu Leu Gln Trp Leu Leu Asn
            900                 905                 910         
Met Ile Gln Asn Asp Pro Val Pro Tyr Val Arg His Lys Ile Leu Asn
        915                 920                 925             
Met Leu Thr Lys Asn Pro Pro Phe Thr Lys Asn Met Glu Ser Pro Leu
    930                 935                 940                 
Cys Asn Glu Ala Leu Val Asp Gln Leu Trp Lys Leu Met Asn Ser Gly
945                 950                 955                 960 
Thr Ser His Asp Trp Arg Leu Arg Cys Gly Ala Val Asp Leu Tyr Phe
                965                 970                 975     
Thr Leu Phe Gly Leu Ser Arg Pro Ser Cys Leu Pro Leu Pro Glu Leu
            980                 985                 990         
Gly Leu Val Leu Asn Leu Lys Glu Lys Lys Ala Val Leu Asn Pro Thr
        995                 1000                1005            
Ile Ile Pro Glu Ser Val Ala Gly Asn Gln Glu Ala Ala Asn Asn Pro
    1010                1015                1020                
Ser Ser His Pro Gln Leu Val Gly Phe Gln Asn Pro Phe Ser Ser Ser
1025                1030                1035                1040
Gln Asp Glu Glu Glu Ile Asp Met Asp Thr Val His Asp Ser Gln Ala
                1045                1050                1055    
Phe Ile Ser His His Leu Asn Met Leu Glu Arg Pro Ser Thr Pro Gly
            1060                1065                1070        
Leu Ser Lys Tyr Arg Pro Ala Ser Ser Arg Ser Ala Leu Ile Pro Gln
        1075                1080                1085            
His Ser Ala Gly Cys Asp Ser Thr Pro Thr Thr Lys Pro Gln Trp Ser
    1090                1095                1100                
Leu Glu Leu Ala Arg Lys Gly Thr Gly Lys Glu Gln Ala Pro Leu Glu
1105                1110                1115                1120
Met Ser Met His Pro Ala Ala Ser Ala Pro Leu Ser Val Phe Thr Lys
                1125                1130                1135    
Glu Ser Thr Ala Ser Lys His Ser Asp His His His His His His His
            1140                1145                1150        
Glu His Lys Lys Lys Lys Lys Lys His Lys His Lys His Lys His Lys
        1155                1160                1165            
His Lys His Asp Ser Lys Glu Lys Asp Lys Glu Pro Phe Thr Phe Ser
    1170                1175                1180                
Ser Pro Ala Ser Gly Arg Ser Ile Arg Ser Pro Ser Leu Ser Asp
1185                1190                1195                


<210> 2021
<211> 510
<212> PRT
<213> Homo sapiens

<400> 2021
Met Tyr Arg Ala Leu Arg Leu Leu Ala Arg Ser Arg Pro Leu Val Arg
 1               5                  10                  15      
Ala Pro Ala Ala Ala Leu Ala Ser Ala Pro Gly Leu Gly Gly Ala Ala
            20                  25                  30          
Val Pro Ser Phe Trp Pro Pro Asn Ala Ala Arg Met Ala Ser Gln Asn
        35                  40                  45              
Ser Phe Arg Ile Glu Tyr Asp Thr Phe Gly Glu Leu Lys Val Pro Asn
    50                  55                  60                  
Asp Lys Tyr Tyr Gly Ala Gln Thr Val Arg Ser Thr Met Asn Phe Lys
65                  70                  75                  80  
Ile Gly Gly Val Thr Glu Arg Met Pro Thr Pro Val Ile Lys Ala Phe
                85                  90                  95      
Gly Ile Leu Lys Arg Ala Ala Ala Glu Val Asn Gln Asp Tyr Gly Leu
            100                 105                 110         
Asp Pro Lys Ile Ala Asn Ala Ile Met Lys Ala Ala Asp Glu Val Ala
        115                 120                 125             
Glu Gly Lys Leu Asn Asp His Phe Pro Leu Val Val Trp Gln Thr Gly
    130                 135                 140                 
Ser Gly Thr Gln Thr Asn Met Asn Val Asn Glu Val Ile Ser Asn Arg
145                 150                 155                 160 
Ala Ile Glu Met Leu Gly Gly Glu Leu Gly Ser Lys Ile Pro Val His
                165                 170                 175     
Pro Asn Asp His Val Asn Lys Ser Gln Ser Ser Asn Asp Thr Phe Pro
            180                 185                 190         
Thr Ala Met His Ile Ala Ala Ala Ile Glu Val His Glu Val Leu Leu
        195                 200                 205             
Pro Gly Leu Gln Lys Leu His Asp Ala Leu Asp Ala Lys Ser Lys Glu
    210                 215                 220                 
Phe Ala Gln Ile Ile Lys Ile Gly Arg Thr His Thr Gln Asp Ala Val
225                 230                 235                 240 
Pro Leu Thr Leu Gly Gln Glu Phe Ser Gly Tyr Val Gln Gln Val Lys
                245                 250                 255     
Tyr Ala Met Thr Arg Ile Lys Ala Ala Met Pro Arg Ile Tyr Glu Leu
            260                 265                 270         
Ala Ala Gly Gly Thr Ala Val Gly Thr Gly Leu Asn Thr Arg Ile Gly
        275                 280                 285             
Phe Ala Glu Lys Val Ala Ala Lys Val Ala Ala Leu Thr Gly Leu Pro
    290                 295                 300                 
Phe Val Thr Ala Pro Asn Lys Phe Glu Ala Leu Ala Ala His Asp Ala
305                 310                 315                 320 
Leu Val Glu Leu Ser Gly Ala Met Asn Thr Thr Ala Cys Ser Leu Met
                325                 330                 335     
Lys Ile Ala Asn Asp Ile Arg Phe Leu Gly Ser Gly Pro Arg Ser Gly
            340                 345                 350         
Leu Gly Glu Leu Ile Leu Pro Glu Asn Glu Pro Gly Ser Ser Ile Met
        355                 360                 365             
Pro Gly Lys Val Asn Pro Thr Gln Cys Glu Ala Met Thr Met Val Ala
    370                 375                 380                 
Ala Gln Val Met Gly Asn His Val Ala Val Thr Val Gly Gly Ser Asn
385                 390                 395                 400 
Gly His Phe Glu Leu Asn Val Phe Lys Pro Met Met Ile Lys Asn Val
                405                 410                 415     
Leu His Ser Ala Arg Leu Leu Gly Asp Ala Ser Val Ser Phe Thr Glu
            420                 425                 430         
Asn Cys Val Val Gly Ile Gln Ala Asn Thr Glu Arg Ile Asn Lys Leu
        435                 440                 445             
Met Asn Glu Ser Leu Met Leu Val Thr Ala Leu Asn Pro His Ile Gly
    450                 455                 460                 
Tyr Asp Lys Ala Ala Lys Ile Ala Lys Thr Ala His Lys Asn Gly Ser
465                 470                 475                 480 
Thr Leu Lys Glu Thr Ala Ile Glu Leu Gly Tyr Leu Thr Ala Glu Gln
                485                 490                 495     
Phe Asp Glu Trp Val Lys Pro Lys Asp Met Leu Gly Pro Lys
            500                 505                 510 


<210> 2022
<211> 206
<212> PRT
<213> Homo sapiens

<400> 2022
Met Ala Ala Asn Lys Pro Lys Gly Gln Asn Ser Leu Ala Leu His Lys
 1               5                  10                  15      
Val Ile Met Val Gly Ser Gly Gly Val Gly Lys Ser Ala Leu Thr Leu
            20                  25                  30          
Gln Phe Met Tyr Asp Glu Phe Val Glu Asp Tyr Glu Pro Thr Lys Ala
        35                  40                  45              
Asp Ser Tyr Arg Lys Lys Val Val Leu Asp Gly Glu Glu Val Gln Ile
    50                  55                  60                  
Asp Ile Leu Asp Thr Ala Gly Gln Glu Asp Tyr Ala Ala Ile Arg Asp
65                  70                  75                  80  
Asn Tyr Phe Arg Ser Gly Glu Gly Phe Leu Cys Val Phe Ser Ile Thr
                85                  90                  95      
Glu Met Glu Ser Phe Ala Ala Thr Ala Asp Phe Arg Glu Gln Ile Leu
            100                 105                 110         
Arg Val Lys Glu Asp Glu Asn Val Pro Phe Leu Leu Val Gly Asn Lys
        115                 120                 125             
Ser Asp Leu Glu Asp Lys Arg Gln Val Ser Val Glu Glu Ala Lys Asn
    130                 135                 140                 
Arg Ala Glu Gln Trp Asn Val Asn Tyr Val Glu Thr Ser Ala Lys Thr
145                 150                 155                 160 
Arg Ala Asn Val Asp Lys Val Phe Phe Asp Leu Met Arg Glu Ile Arg
                165                 170                 175     
Ala Arg Lys Met Glu Asp Ser Lys Glu Lys Asn Gly Lys Lys Lys Arg
            180                 185                 190         
Lys Ser Leu Ala Lys Arg Ile Arg Glu Arg Cys Cys Ile Leu
        195                 200                 205     


<210> 2023
<211> 731
<212> PRT
<213> Homo sapiens

<400> 2023
Met Ser Asp Thr Phe Thr Asp Asn Trp Thr Asp Gly Ser His Tyr Asp
 1               5                  10                  15      
Asn Thr Gly Phe Val Ala Glu Glu Thr Thr Ala Glu Asn Ala Asn Ser
            20                  25                  30          
Asn Pro Leu Leu Ser Ser Lys Ser Arg Ser Thr Ser Ser His Gly Arg
        35                  40                  45              
Arg Pro Leu Ile Arg Gln Asp Arg Ile Val Gly Val Pro Leu Glu Leu
    50                  55                  60                  
Glu Gln Ser Thr His Arg His Thr Pro Glu Thr Glu Val Pro Pro Ser
65                  70                  75                  80  
Asn Pro Trp Gln Asn Trp Thr Arg Thr Pro Ser Pro Phe Glu Asp Arg
                85                  90                  95      
Thr Ala Phe Pro Ser Lys Leu Glu Thr Thr Pro Thr Thr Ser Pro Leu
            100                 105                 110         
Pro Glu Arg Lys Glu His Ile Lys Glu Ser Thr Glu Ile Pro Ser Pro
        115                 120                 125             
Phe Ser Pro Gly Val Pro Trp Glu Tyr His Asp Ser Asn Pro Asn Arg
    130                 135                 140                 
Ser Leu Ser Asn Val Phe Ser Gln Ile His Cys Arg Pro Glu Ser Ser
145                 150                 155                 160 
Lys Gly Val Ile Ser Ile Ser Lys Ser Thr Glu Arg Leu Ser Pro Leu
                165                 170                 175     
Met Lys Asp Ile Lys Ser Asn Lys Phe Lys Lys Ser Gln Ser Ile Asp
            180                 185                 190         
Glu Ile Asp Ile Gly Thr Tyr Lys Val Tyr Asn Ile Pro Leu Glu Asn
        195                 200                 205             
Tyr Ala Ser Gly Ser Asp His Leu Gly Ser His Glu Arg Pro Asp Lys
    210                 215                 220                 
Met Leu Gly Pro Glu His Gly Met Ser Ser Met Ser Arg Ser Gln Ser
225                 230                 235                 240 
Val Pro Met Leu Asp Asp Glu Met Leu Thr Tyr Gly Ser Ser Lys Gly
                245                 250                 255     
Pro Gln Gln Gln Lys Ala Ser Met Thr Lys Lys Val Tyr Gln Phe Asp
            260                 265                 270         
Gln Ser Phe Asn Pro Gln Gly Ser Val Glu Val Lys Ala Glu Lys Arg
        275                 280                 285             
Ile Pro Pro Pro Phe Gln His Asn Pro Glu Tyr Val Gln Gln Ala Ser
    290                 295                 300                 
Lys Asn Ile Ala Lys Asp Leu Ile Ser Pro Arg Ala Tyr Arg Gly Tyr
305                 310                 315                 320 
Pro Pro Met Glu Gln Met Phe Ser Phe Ser Gln Pro Ser Val Asn Glu
                325                 330                 335     
Asp Ala Val Val Asn Ala Gln Phe Ala Ser Gln Gly Ala Arg Ala Gly
            340                 345                 350         
Phe Leu Arg Arg Ala Asp Ser Leu Val Ser Ala Thr Glu Met Ala Met
        355                 360                 365             
Phe Arg Arg Val Asn Glu Pro His Glu Leu Pro Pro Thr Asp Arg Tyr
    370                 375                 380                 
Gly Arg Pro Pro Tyr Arg Gly Gly Leu Asp Arg Gln Ser Ser Val Thr
385                 390                 395                 400 
Val Thr Glu Ser Gln Phe Leu Lys Arg Asn Gly Arg Tyr Glu Asp Glu
                405                 410                 415     
His Pro Ser Tyr Gln Glu Val Lys Ala Gln Ala Gly Ser Phe Pro Val
            420                 425                 430         
Lys Asn Leu Thr Gln Arg Arg Pro Leu Ser Ala Arg Ser Tyr Ser Thr
        435                 440                 445             
Glu Ser Tyr Gly Ala Ser Gln Thr Arg Pro Val Ser Ala Arg Pro Thr
    450                 455                 460                 
Met Ala Ala Leu Leu Glu Lys Ile Pro Ser Asp Tyr Asn Leu Gly Asn
465                 470                 475                 480 
Tyr Gly Asp Lys Pro Ser Asp Asn Ser Asp Leu Lys Thr Arg Pro Thr
                485                 490                 495     
Pro Val Lys Gly Glu Glu Ser Cys Gly Lys Met Pro Ala Asp Trp Arg
            500                 505                 510         
Gln Gln Leu Leu Arg His Ile Glu Ala Arg Arg Leu Asp Arg Thr Pro
        515                 520                 525             
Ser Gln Gln Ser Asn Ile Leu Asp Asn Gly Gln Glu Asp Val Ser Pro
    530                 535                 540                 
Ser Gly Gln Trp Asn Pro Tyr Pro Leu Gly Arg Arg Asp Val Pro Pro
545                 550                 555                 560 
Asp Thr Ile Thr Lys Lys Ala Gly Ser His Ile Gln Thr Leu Met Gly
                565                 570                 575     
Ser Gln Ser Leu Gln His Arg Ser Arg Glu Gln Gln Pro Tyr Glu Gly
            580                 585                 590         
Asn Ile Asn Lys Val Thr Ile Gln Gln Phe Gln Ser Pro Leu Pro Ile
        595                 600                 605             
Gln Ile Pro Ser Ser Gln Ala Thr Arg Gly Pro Gln Pro Gly Arg Cys
    610                 615                 620                 
Leu Ile Gln Thr Lys Gly Gln Arg Ser Met Asp Gly Tyr Pro Glu Gln
625                 630                 635                 640 
Phe Cys Val Arg Ile Glu Lys Asn Pro Gly Leu Gly Phe Ser Ile Ser
                645                 650                 655     
Gly Gly Ile Ser Gly Gln Gly Asn Pro Phe Lys Pro Ser Asp Lys Gly
            660                 665                 670         
Ile Phe Val Thr Arg Val Gln Pro Asp Gly Pro Ala Ser Asn Leu Leu
        675                 680                 685             
Gln Pro Gly Asp Lys Ile Leu Gln Ala Asn Gly His Ser Phe Val His
    690                 695                 700                 
Met Glu His Glu Lys Ala Val Leu Leu Leu Lys Ser Phe Gln Asn Thr
705                 710                 715                 720 
Val Asp Leu Val Ile Gln Arg Glu Leu Thr Val
                725                 730     


<210> 2024
<211> 137
<212> PRT
<213> Homo sapiens

<400> 2024
Met Ile Val Val Lys Val Gly Ile Ile Ser Gly Gly Asn Cys Val Cys
 1               5                  10                  15      
His Thr Phe Arg Lys Val Ile Lys Glu Arg Asn Thr Leu Asn Val Met
            20                  25                  30          
Asn Val Gly Lys Leu Ser Gly Arg Ser His Ile Ser Leu Asp Ile Arg
        35                  40                  45              
Gly Cys Thr Gln Asp Arg Asn Pro Phe Asn Val Met Asn Val Lys Lys
    50                  55                  60                  
Leu Ser Gly Ile Ser Gln Thr Ser Leu Asn Ile Lys Asp His Thr Gln
65                  70                  75                  80  
Gly Arg Asn Leu Leu Asn Ala Met Asn Val Gly Lys Pro Leu Ala Ile
                85                  90                  95      
Ser Gln Pro Ser His Tyr Thr Arg Glu His Ile Gln Gly Arg Asn Pro
            100                 105                 110         
Ile Asn Val Met Arg Val Gly Lys Leu Phe Ala Arg Asn Leu Thr Ser
        115                 120                 125             
Leu Asn Ile Arg Glu His Thr Gln Gly
    130                 135         


<210> 2025
<211> 149
<212> PRT
<213> Homo sapiens

<400> 2025
Met Met Ile Ile Pro His Leu Leu Arg Asp Lys Asp Gln Arg Ser Thr
 1               5                  10                  15      
Thr Ala Thr Ser Pro Arg Thr Arg Gln Cys Trp Gly Met Glu Asn Glu
            20                  25                  30          
Gly Val Gln Leu Trp Pro Ser Gln Ser Ser Gly Gly Asp Glu Thr His
        35                  40                  45              
Leu Pro Leu Ser Leu Trp Ala Arg Leu Met Pro Gly Ala Ser Val Asp
    50                  55                  60                  
Arg Gly His Ala Pro Gly Leu Pro Lys Leu Glu Lys Ala Ala Arg Leu
65                  70                  75                  80  
Arg Ser Glu Gly Gln Asn Ser Thr Val Ser Pro Thr Glu Ser Arg Trp
                85                  90                  95      
Glu Gln Gly Arg Trp Leu Pro Arg Leu Cys Gly Arg Ile Arg Phe Leu
            100                 105                 110         
Ala Val Glu Val Ala Cys Thr Pro Gln Leu Val Leu Pro Val Ser Asn
        115                 120                 125             
Asp Trp Ser Phe Leu Leu Leu Ser Leu His Leu Pro Pro Ser Pro Ser
    130                 135                 140                 
Pro Ala Leu Leu Leu
145                 


<210> 2026
<211> 465
<212> PRT
<213> Homo sapiens

<400> 2026
Met Arg Arg Pro Arg Gly Glu Pro Gly Pro Arg Ala Pro Arg Pro Thr
 1               5                  10                  15      
Glu Gly Ala Thr Cys Ala Gly Pro Gly Glu Ser Trp Ser Pro Ser Pro
            20                  25                  30          
Asn Ser Met Leu Arg Val Leu Leu Ser Ala Gln Thr Ser Pro Ala Arg
        35                  40                  45              
Leu Ser Gly Leu Leu Leu Ile Pro Pro Val Gln Pro Cys Cys Leu Gly
    50                  55                  60                  
Pro Ser Lys Trp Gly Asp Arg Pro Val Gly Gly Gly Pro Ser Ala Gly
65                  70                  75                  80  
Pro Val Gln Gly Leu Gln Arg Leu Leu Glu Gln Ala Lys Ser Pro Gly
                85                  90                  95      
Glu Leu Leu Arg Trp Leu Gly Gln Asn Pro Ser Lys Val Arg Ala His
            100                 105                 110         
His Tyr Ser Val Ala Leu Arg Arg Leu Gly Gln Leu Leu Gly Ser Arg
        115                 120                 125             
Pro Arg Pro Pro Pro Val Glu Gln Val Thr Leu Gln Asp Leu Ser Gln
    130                 135                 140                 
Leu Ile Ile Arg Asn Cys Pro Ser Phe Asp Ile His Thr Ile His Val
145                 150                 155                 160 
Cys Leu His Leu Ala Val Leu Leu Gly Phe Pro Ser Asp Gly Pro Leu
                165                 170                 175     
Val Cys Ala Leu Glu Gln Glu Arg Arg Leu Arg Leu Pro Pro Lys Pro
            180                 185                 190         
Pro Pro Pro Leu Gln Pro Leu Leu Arg Gly Gly Gln Gly Leu Glu Ala
        195                 200                 205             
Ala Leu Ser Cys Pro Arg Phe Leu Arg Tyr Pro Arg Gln His Leu Ile
    210                 215                 220                 
Ser Ser Leu Ala Glu Ala Arg Pro Glu Glu Leu Thr Pro His Val Met
225                 230                 235                 240 
Val Leu Leu Ala Gln His Leu Ala Arg His Arg Leu Arg Glu Pro Gln
                245                 250                 255     
Leu Leu Glu Ala Ile Ala His Phe Leu Val Val Gln Glu Thr Gln Leu
            260                 265                 270         
Ser Ser Lys Val Val Gln Lys Leu Val Leu Pro Phe Gly Arg Leu Asn
        275                 280                 285             
Tyr Leu Pro Leu Glu Gln Gln Phe Met Pro Cys Leu Glu Arg Ile Leu
    290                 295                 300                 
Ala Arg Glu Ala Gly Val Ala Pro Leu Ala Thr Val Asn Ile Leu Met
305                 310                 315                 320 
Ser Leu Cys Gln Leu Arg Cys Leu Pro Phe Arg Ala Leu His Phe Val
                325                 330                 335     
Phe Ser Pro Gly Phe Ile Asn Tyr Ile Ser Gly Thr Pro His Ala Leu
            340                 345                 350         
Ile Val Arg Arg Tyr Leu Ser Leu Leu Asp Thr Ala Val Glu Leu Glu
        355                 360                 365             
Leu Pro Gly Tyr Arg Gly Pro Arg Leu Pro Arg Arg Gln Gln Val Pro
    370                 375                 380                 
Ile Phe Pro Gln Pro Leu Ile Thr Asp Arg Ala Arg Cys Lys Tyr Ser
385                 390                 395                 400 
His Lys Asp Ile Val Ala Glu Gly Leu Arg Gln Leu Leu Gly Glu Glu
                405                 410                 415     
Lys Tyr Arg Gln Asp Leu Thr Val Pro Pro Gly Tyr Cys Thr Asp Phe
            420                 425                 430         
Leu Leu Cys Ala Ser Ser Ser Gly Ala Val Leu Pro Val Arg Thr Gln
        435                 440                 445             
Asp Pro Phe Leu Pro Tyr Pro Pro Arg Ser Cys Pro Ser Ser Arg Ala
    450                 455                 460                 
Thr
465 


<210> 2027
<211> 881
<212> PRT
<213> Homo sapiens

<400> 2027
Met Thr Lys Ser Met Glu Arg Gly Arg Pro Pro Glu Asn Arg Lys Met
 1               5                  10                  15      
Phe Gln Arg Ala Gln Glu Leu Arg Arg Arg Ala Glu Asp Tyr His Lys
            20                  25                  30          
Cys Lys Ile Pro Pro Ser Ala Arg Lys Ala Leu Cys Asn Trp Val Arg
        35                  40                  45              
Met Ala Ala Ala Glu His Arg His Ser Ser Gly Leu Pro Tyr Trp Pro
    50                  55                  60                  
Tyr Leu Thr Ala Glu Thr Leu Lys Asn Arg Met Gly His Gln Pro Pro
65                  70                  75                  80  
Pro Pro Thr Gln Gln His Ser Ile Thr Asp Asn Ser Leu Ser Leu Lys
                85                  90                  95      
Thr Pro Pro Glu Cys Leu Leu Thr Pro Leu Pro Pro Ser Ala Asp Asp
            100                 105                 110         
Asn Leu Lys Thr Pro Pro Glu Cys Val Leu Thr Pro Leu Pro Pro Ser
        115                 120                 125             
Ala Asp Asp Asn Leu Lys Thr Pro Pro Glu Cys Val Leu Thr Pro Leu
    130                 135                 140                 
Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Pro Glu Cys Leu Leu
145                 150                 155                 160 
Thr Pro Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Pro Glu
                165                 170                 175     
Cys Leu Leu Thr Pro Leu Pro Pro Ser Ala Leu Pro Ser Ala Pro Pro
            180                 185                 190         
Ser Ala Asp Asp Asn Leu Lys Thr Arg Ala Glu Cys Leu Leu His Pro
        195                 200                 205             
Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Ser Glu Arg Gln
    210                 215                 220                 
Leu Thr Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp Asn Ile
225                 230                 235                 240 
Lys Thr Pro Ala Glu Arg Leu Arg Gly Pro Leu Pro Pro Ser Ala Asp
                245                 250                 255     
Asp Asn Leu Lys Thr Pro Ser Glu Arg Gln Leu Thr Ala Leu Pro Pro
            260                 265                 270         
Ser Ala Asp Asp Asn Ile Lys Thr Pro Ala Glu Arg Leu Arg Gly Pro
        275                 280                 285             
Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Ser Glu Arg Gln
    290                 295                 300                 
Leu Thr Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp Asn Ile
305                 310                 315                 320 
Lys Thr Pro Ala Glu Arg Leu Arg Gly Pro Leu Pro Pro Ser Ala Asp
                325                 330                 335     
Asp Asn Leu Lys Thr Pro Ser Glu Arg Gln Leu Thr Pro Leu Pro Pro
            340                 345                 350         
Ser Ala Pro Pro Ser Ala Asp Asp Asn Ile Lys Thr Pro Ala Phe His
        355                 360                 365             
Pro Gln Arg Met Ile Ser Arg His Leu Pro Ser Val Ser Ser Leu Pro
    370                 375                 380                 
Phe His Pro Gln Leu His Pro Gln Gln Met Ile Ile Ser Arg Tyr Leu
385                 390                 395                 400 
Leu Ser Val Cys Gly Phe Arg Phe His His Gln Pro Met Ile Ile Ser
                405                 410                 415     
Arg His Leu Pro Ser Val Ser Ser Leu Pro Phe His Pro Gln Leu His
            420                 425                 430         
Pro Gln Gln Met Ile Ile Ser Arg His Leu Pro Ser Val Cys Gly Gly
        435                 440                 445             
Arg Phe His Pro Gln Gln Met Ile Ile Ser Arg His Leu Pro Ser Val
    450                 455                 460                 
Ser Ser Leu Pro Phe His Pro Gln Leu His Pro Gln Gln Met Met Ile
465                 470                 475                 480 
Ser Arg His Leu Pro Ser Val Cys Gly Gly Arg Phe His Pro Gln Arg
                485                 490                 495     
Met Ile Ile Ser Arg His Leu Pro Ser Val Ser Ser Leu Pro Phe His
            500                 505                 510         
Pro Gln Leu His Pro Gln Gln Met Ile Ile Ser Arg His Leu Pro Ser
        515                 520                 525             
Val Cys Gly Gly Arg Phe His Pro Gln Gln Met Ile Ile Ser Arg His
    530                 535                 540                 
Leu Pro Ser Val Ser Ser Leu Pro Phe His Pro Gln Leu His Pro Gln
545                 550                 555                 560 
Gln Met Ile Ile Ser Arg His Leu Pro Ser Val Cys Gly Gly Arg Phe
                565                 570                 575     
His Pro Gln Arg Met Ile Ile Ser Arg His Leu Pro Ser Val Ser Ser
            580                 585                 590         
Leu Pro Phe His Pro Gln Leu His Pro Gln Gln Met Ile Ile Ser Arg
        595                 600                 605             
His Leu Pro Ser Val Cys Gly Glu Arg Leu Arg Gly Pro Leu Pro Pro
    610                 615                 620                 
Ser Ala Asp Asp Asn Leu Lys Thr Leu Ser Glu Arg Gln Leu Thr Pro
625                 630                 635                 640 
Leu Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp Asn Ile Lys Thr Pro
                645                 650                 655     
Ala Glu Arg Leu Arg Gly Pro Leu Pro Pro Ser Ala Asp Asp Asn Leu
            660                 665                 670         
Lys Thr Pro Ser Glu Arg Gln Leu Thr Pro Leu Pro Pro Ser Ala Pro
        675                 680                 685             
Pro Ser Ala Asp Asp Asn Ile Lys Thr Pro Ala Glu Arg Leu Arg Gly
    690                 695                 700                 
Pro Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Ser Glu Arg
705                 710                 715                 720 
Gln Leu Thr Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp Asn
                725                 730                 735     
Ile Lys Thr Pro Ala Glu Arg Leu Arg Gly Pro Leu Pro Pro Ser Ala
            740                 745                 750         
Asp Asp Asn Leu Lys Thr Pro Pro Leu Ala Thr Gln Glu Ala Glu Ala
        755                 760                 765             
Glu Lys Pro Arg Lys Pro Lys Arg Gln Arg Ala Ala Glu Met Glu Pro
    770                 775                 780                 
Pro Pro Glu Pro Lys Arg Arg Arg Val Gly Asp Val Glu Pro Ser Arg
785                 790                 795                 800 
Lys Pro Lys Arg Arg Arg Ala Ala Asp Val Glu Pro Ser Ser Pro Glu
                805                 810                 815     
Pro Lys Arg Arg Arg Val Gly Asp Val Glu Pro Ser Arg Lys Pro Lys
            820                 825                 830         
Arg Arg Arg Ala Ala Asp Val Glu Pro Ser Ser Pro Glu Pro Lys Arg
        835                 840                 845             
Arg Arg Val Gly Asp Val Glu Pro Ser Arg Lys Pro Lys Arg Arg Arg
    850                 855                 860                 
Ala Ala Asp Val Glu Pro Ser Leu Pro Glu Pro Lys Arg Arg Arg Leu
865                 870                 875                 880 
Ser
    


<210> 2028
<211> 116
<212> PRT
<213> Homo sapiens

<400> 2028
Met Glu Pro Ala Ala Gly Ser Ser Met Glu Pro Ser Ala Asp Trp Leu
 1               5                  10                  15      
Ala Thr Ala Ala Ala Arg Gly Arg Val Glu Glu Val Arg Ala Leu Leu
            20                  25                  30          
Glu Ala Gly Ala Leu Pro Asn Ala Pro Asn Ser Tyr Gly Arg Arg Pro
        35                  40                  45              
Ile Gln Val Gly Arg Gly Ser Ala Ala Gly Ala Gly Asp Gly Gly Arg
    50                  55                  60                  
Leu Trp Arg Thr Lys Phe Ala Gly Glu Leu Glu Ser Gly Ser Ala Ser
65                  70                  75                  80  
Ile Leu Arg Lys Lys Gly Arg Leu Pro Gly Glu Phe Ser Glu Gly Val
                85                  90                  95      
Cys Asn His Arg Pro Pro Pro Gly Asp Ala Leu Gly Ala Trp Glu Ala
            100                 105                 110         
Lys Glu Glu Glu
        115     


<210> 2029
<211> 1320
<212> PRT
<213> Homo sapiens

<400> 2029
Met Met Asn Arg Thr Thr Pro Asp Gln Glu Leu Ala Pro Ala Ser Glu
 1               5                  10                  15      
Pro Val Trp Glu Arg Pro Trp Ser Val Glu Glu Ile Arg Arg Ser Ser
            20                  25                  30          
Gln Ser Trp Ser Leu Ala Ala Asp Ala Gly Leu Leu Gln Phe Leu Gln
        35                  40                  45              
Glu Phe Ser Gln Gln Thr Ile Ser Arg Thr His Glu Ile Lys Lys Gln
    50                  55                  60                  
Val Asp Gly Leu Ile Arg Glu Thr Lys Ala Thr Asp Cys Arg Leu His
65                  70                  75                  80  
Asn Val Phe Asn Asp Phe Leu Met Leu Ser Asn Thr Gln Phe Ile Glu
                85                  90                  95      
Asn Arg Val Tyr Asp Glu Glu Val Glu Glu Pro Val Leu Lys Ala Glu
            100                 105                 110         
Ala Glu Lys Thr Glu Gln Glu Lys Thr Arg Glu Gln Lys Glu Val Asp
        115                 120                 125             
Leu Ile Pro Lys Val Gln Glu Ala Val Asn Tyr Gly Leu Gln Val Leu
    130                 135                 140                 
Asp Ser Ala Phe Glu Gln Leu Asp Ile Lys Ala Gly Asn Ser Asp Ser
145                 150                 155                 160 
Glu Glu Asp Asp Ala Asn Gly Arg Val Glu Leu Ile Leu Glu Pro Lys
                165                 170                 175     
Asp Leu Tyr Ile Asp Arg Pro Leu Pro Tyr Leu Ile Gly Ser Lys Leu
            180                 185                 190         
Phe Met Glu Gln Glu Asp Val Gly Leu Gly Glu Leu Ser Ser Glu Glu
        195                 200                 205             
Gly Ser Val Gly Ser Asp Arg Gly Ser Ile Val Asp Thr Glu Glu Glu
    210                 215                 220                 
Lys Glu Glu Glu Glu Ser Asp Glu Asp Phe Ala His His Ser Asp Asn
225                 230                 235                 240 
Glu Gln Asn Gln His Thr Thr Gln Met Ser Asp Glu Glu Glu Asp Asp
                245                 250                 255     
Asp Gly Cys Asp Leu Phe Ala Asp Ser Glu Lys Glu Glu Glu Asp Ile
            260                 265                 270         
Glu Asp Ile Glu Glu Asn Thr Arg Pro Lys Arg Ser Arg Pro Thr Ser
        275                 280                 285             
Phe Ala Asp Glu Leu Ala Ala Arg Ile Lys Gly Asp Ala Val Gly Arg
    290                 295                 300                 
Val Asp Glu Glu Pro Thr Thr Leu Pro Ser Gly Glu Ala Lys Pro Arg
305                 310                 315                 320 
Lys Thr Leu Lys Glu Lys Lys Glu Arg Arg Thr Pro Ser Asp Asp Glu
                325                 330                 335     
Glu Asp Asn Leu Phe Ala Pro Pro Lys Leu Thr Asp Glu Asp Phe Ser
            340                 345                 350         
Pro Phe Gly Ser Gly Gly Gly Leu Phe Ser Gly Gly Lys Gly Leu Phe
        355                 360                 365             
Asp Asp Glu Asp Glu Glu Ser Asp Leu Phe Thr Glu Ala Pro Gln Asp
    370                 375                 380                 
Arg Gln Ala Gly Ala Ser Val Lys Glu Glu Ser Ser Ser Ser Lys Pro
385                 390                 395                 400 
Gly Lys Lys Ile Pro Ala Gly Ala Val Ser Val Phe Leu Gly Asp Thr
                405                 410                 415     
Asp Val Phe Gly Ala Ala Ser Val Pro Ser Met Lys Glu Pro Gln Lys
            420                 425                 430         
Pro Glu Gln Pro Thr Pro Arg Lys Ser Pro Tyr Gly Pro Pro Pro Thr
        435                 440                 445             
Gly Leu Phe Asp Asp Asp Asp Gly Asp Asp Asp Asp Asp Phe Phe Ser
    450                 455                 460                 
Ala Pro His Ser Lys Pro Ser Lys Thr Gly Lys Val Gln Ser Thr Ala
465                 470                 475                 480 
Asp Ile Phe Gly Asp Glu Glu Gly Asp Leu Phe Lys Glu Lys Ala Val
                485                 490                 495     
Ala Ser Pro Glu Ala Thr Val Ser Gln Thr Asp Glu Asn Lys Ala Arg
            500                 505                 510         
Ala Glu Lys Lys Val Thr Leu Ser Ser Ser Lys Asn Leu Lys Pro Ser
        515                 520                 525             
Ser Glu Thr Lys Thr Gln Lys Gly Leu Phe Ser Asp Glu Glu Asp Ser
    530                 535                 540                 
Glu Asp Leu Phe Ser Ser Gln Ser Ala Ser Lys Leu Lys Gly Ala Ser
545                 550                 555                 560 
Leu Leu Pro Gly Lys Leu Pro Thr Leu Val Ser Leu Phe Asp Asp Glu
                565                 570                 575     
Asp Glu Glu Asp Asn Leu Phe Gly Gly Thr Ala Ala Lys Lys Gln Thr
            580                 585                 590         
Leu Cys Leu Gln Ala Gln Arg Glu Glu Lys Ala Lys Ala Ser Glu Leu
        595                 600                 605             
Ser Lys Lys Lys Ala Ser Ala Leu Leu Phe Ser Ser Asp Glu Glu Asp
    610                 615                 620                 
Gln Trp Asn Ile Pro Ala Ser Gln Thr His Leu Ala Ser Asp Ser Arg
625                 630                 635                 640 
Ser Lys Gly Glu Pro Arg Asp Ser Gly Thr Leu Gln Ser Gln Glu Ala
                645                 650                 655     
Lys Ala Val Lys Lys Thr Ser Leu Phe Glu Glu Asp Glu Glu Asp Asp
            660                 665                 670         
Leu Phe Ala Ile Ala Lys Asp Ser Gln Lys Lys Thr Gln Arg Val Ser
        675                 680                 685             
Leu Leu Phe Glu Asp Asp Val Asp Ser Gly Gly Ser Leu Phe Gly Ser
    690                 695                 700                 
Pro Pro Thr Ser Val Pro Pro Ala Thr Lys Lys Lys Glu Thr Val Ser
705                 710                 715                 720 
Glu Ala Pro Pro Leu Leu Phe Ser Asp Glu Glu Glu Lys Glu Ala Gln
                725                 730                 735     
Leu Gly Val Lys Ser Val Asp Lys Lys Val Glu Ser Ala Lys Glu Ser
            740                 745                 750         
Leu Lys Phe Gly Arg Thr Asp Val Ala Glu Ser Glu Lys Glu Gly Leu
        755                 760                 765             
Leu Thr Arg Ser Ala Gln Glu Thr Val Lys His Ser Asp Leu Phe Ser
    770                 775                 780                 
Ser Ser Ser Pro Trp Asp Lys Gly Thr Lys Pro Arg Thr Lys Thr Val
785                 790                 795                 800 
Leu Ser Leu Phe Asp Glu Glu Glu Asp Lys Met Glu Asp Gln Asn Ile
                805                 810                 815     
Ile Gln Ala Pro Gln Lys Glu Val Gly Lys Gly Arg Asp Pro Asp Ala
            820                 825                 830         
His Pro Lys Ser Thr Gly Val Phe Gln Asp Glu Glu Leu Leu Phe Ser
        835                 840                 845             
His Lys Leu Gln Lys Asp Asn Asp Pro Asp Val Asp Leu Phe Ala Gly
    850                 855                 860                 
Thr Lys Lys Thr Lys Leu Leu Glu Pro Ser Val Gly Ser Leu Phe Gly
865                 870                 875                 880 
Asp Asp Glu Asp Asp Asp Leu Phe Ser Ser Ala Lys Ser Gln Pro Leu
                885                 890                 895     
Val Gln Glu Lys Lys Arg Val Val Lys Lys Asp His Ser Val Asp Ser
            900                 905                 910         
Phe Lys Asn Gln Lys His Pro Glu Ser Ile Gln Gly Ser Lys Glu Lys
        915                 920                 925             
Gly Ile Trp Lys Pro Glu Thr Pro Gln Ala Asn Leu Ala Ile Asn Pro
    930                 935                 940                 
Ala Ala Leu Leu Pro Thr Ala Ala Ser Gln Ile Ser Glu Val Lys Pro
945                 950                 955                 960 
Val Leu Pro Glu Leu Ala Phe Pro Ser Ser Glu His Arg Arg Ser His
                965                 970                 975     
Gly Leu Glu Ser Val Pro Val Leu Pro Gly Ser Gly Glu Ala Gly Val
            980                 985                 990         
Ser Phe Asp Leu Pro Ala Gln Ala Asp Thr Leu His Ser Ala Asn Lys
        995                 1000                1005            
Ser Arg Val Lys Met Arg Gly Lys Arg Arg Pro Gln Thr Arg Ala Ala
    1010                1015                1020                
Arg Arg Leu Ala Ala Gln Glu Ser Ser Glu Thr Glu Asp Met Ser Val
1025                1030                1035                1040
Pro Arg Gly Pro Ile Ala Gln Trp Ala Asp Gly Ala Ile Ser Pro Asn
                1045                1050                1055    
Gly His Arg Pro Gln Leu Arg Ala Ala Ser Gly Glu Asp Ser Thr Glu
            1060                1065                1070        
Glu Ala Leu Ala Ala Ala Ala Ala Pro Trp Glu Gly Gly Pro Val Pro
        1075                1080                1085            
Gly Val Asp Arg Ser Pro Phe Ala Lys Ser Leu Gly His Ser Arg Gly
    1090                1095                1100                
Glu Ala Asp Leu Phe Asp Ser Gly Asp Ile Phe Ser Thr Gly Thr Gly
1105                1110                1115                1120
Ser Gln Ser Val Glu Arg Thr Lys Pro Lys Ala Lys Ile Ala Glu Asn
                1125                1130                1135    
Pro Ala Asn Pro Pro Val Gly Gly Lys Ala Lys Ser Pro Met Phe Pro
            1140                1145                1150        
Ala Leu Gly Glu Ala Ser Ser Asp Asp Asp Leu Phe Gln Ser Ala Lys
        1155                1160                1165            
Pro Lys Pro Ala Lys Lys Thr Asn Pro Phe Pro Leu Leu Glu Asp Glu
    1170                1175                1180                
Asp Asp Leu Phe Thr Asp Gln Lys Val Lys Lys Asn Glu Thr Lys Ser
1185                1190                1195                1200
Asn Ser Gln Gln Asp Val Ile Leu Thr Thr Gln Asp Ile Phe Glu Asp
                1205                1210                1215    
Asp Ile Phe Ala Thr Glu Ala Ile Lys Pro Ser Gln Lys Thr Arg Glu
            1220                1225                1230        
Lys Glu Lys Thr Leu Glu Ser Asn Leu Phe Asp Asp Asn Ile Asp Ile
        1235                1240                1245            
Phe Ala Asp Leu Thr Val Lys Pro Lys Glu Lys Ser Lys Lys Lys Val
    1250                1255                1260                
Glu Ala Lys Ser Ile Phe Asp Asp Asp Met Asp Asp Ile Phe Ser Ser
1265                1270                1275                1280
Gly Ile Gln Ala Lys Thr Thr Lys Pro Lys Ser Arg Ser Ala Gln Ala
                1285                1290                1295    
Ala Pro Glu Pro Arg Phe Glu His Lys Val Ser Asn Ile Phe Asp Asp
            1300                1305                1310        
Pro Leu Asn Ala Phe Gly Gly Gln
        1315                1320


<210> 2030
<211> 147
<212> PRT
<213> Homo sapiens

<400> 2030
Met Gly Phe Ile Phe Ser Lys Ser Met Asn Glu Ser Met Lys Asn Gln
 1               5                  10                  15      
Lys Glu Phe Met Leu Met Asn Ala Arg Leu Gln Leu Glu Arg Gln Leu
            20                  25                  30          
Ile Met Gln Ser Glu Met Arg Glu Arg Gln Met Ala Met Gln Ile Ala
        35                  40                  45              
Trp Ser Arg Glu Phe Leu Lys Tyr Phe Gly Thr Phe Phe Gly Leu Ala
    50                  55                  60                  
Ala Ile Ser Leu Thr Ala Gly Ala Ile Lys Lys Lys Lys Pro Ala Phe
65                  70                  75                  80  
Leu Val Pro Ile Val Pro Leu Ser Phe Ile Leu Thr Tyr Gln Tyr Asp
                85                  90                  95      
Leu Gly Tyr Gly Thr Leu Leu Glu Arg Met Lys Gly Glu Ala Glu Asp
            100                 105                 110         
Ile Leu Glu Thr Glu Lys Ser Lys Leu Gln Leu Pro Arg Gly Met Ile
        115                 120                 125             
Thr Phe Glu Ser Ile Glu Lys Ala Arg Lys Glu Gln Ser Arg Phe Phe
    130                 135                 140                 
Ile Asp Lys
145         


<210> 2031
<211> 925
<212> PRT
<213> Homo sapiens

<400> 2031
Met Thr Thr Glu Gln Arg Arg Ser Leu Gln Ala Phe Gln Asp Tyr Ile
 1               5                  10                  15      
Arg Lys Thr Leu Asp Pro Thr Tyr Ile Leu Ser Tyr Met Ala Pro Trp
            20                  25                  30          
Phe Arg Glu Glu Glu Val Gln Tyr Ile Gln Ala Glu Lys Asn Asn Lys
        35                  40                  45              
Gly Pro Met Glu Ala Ala Thr Leu Phe Leu Lys Phe Leu Leu Glu Leu
    50                  55                  60                  
Gln Glu Glu Gly Trp Phe Arg Gly Phe Leu Asp Ala Leu Asp His Ala
65                  70                  75                  80  
Gly Tyr Ser Gly Leu Tyr Glu Ala Ile Glu Ser Trp Asp Phe Lys Lys
                85                  90                  95      
Ile Glu Lys Leu Glu Glu Tyr Arg Leu Leu Leu Lys Arg Leu Gln Pro
            100                 105                 110         
Glu Phe Lys Thr Arg Ile Ile Pro Thr Asp Ile Ile Ser Asp Leu Ser
        115                 120                 125             
Glu Cys Leu Ile Asn Gln Glu Cys Glu Glu Ile Leu Gln Ile Cys Ser
    130                 135                 140                 
Thr Lys Gly Met Met Ala Gly Ala Glu Lys Leu Val Glu Cys Leu Leu
145                 150                 155                 160 
Arg Ser Asp Lys Glu Asn Trp Pro Lys Thr Leu Lys Leu Ala Leu Glu
                165                 170                 175     
Lys Glu Arg Asn Lys Phe Ser Glu Leu Trp Ile Val Glu Lys Gly Ile
            180                 185                 190         
Lys Asp Val Glu Thr Glu Asp Leu Glu Asp Lys Met Glu Thr Ser Asp
        195                 200                 205             
Ile Gln Ile Phe Tyr Gln Glu Asp Pro Glu Cys Gln Asn Leu Ser Glu
    210                 215                 220                 
Asn Ser Cys Pro Pro Ser Glu Val Ser Asp Thr Asn Leu Tyr Ser Pro
225                 230                 235                 240 
Phe Lys Pro Arg Asn Tyr Gln Leu Glu Leu Ala Leu Pro Ala Met Lys
                245                 250                 255     
Gly Lys Asn Thr Ile Ile Cys Ala Pro Thr Gly Cys Gly Lys Thr Phe
            260                 265                 270         
Val Ser Leu Leu Ile Cys Glu His His Leu Lys Lys Phe Pro Gln Gly
        275                 280                 285             
Gln Lys Gly Lys Val Val Phe Phe Ala Asn Gln Ile Pro Val Tyr Glu
    290                 295                 300                 
Gln Gln Lys Ser Val Phe Ser Lys Tyr Phe Glu Arg His Gly Tyr Arg
305                 310                 315                 320 
Val Thr Gly Ile Ser Gly Ala Thr Ala Glu Asn Val Pro Val Glu Gln
                325                 330                 335     
Ile Val Glu Asn Asn Asp Ile Ile Ile Leu Thr Pro Gln Ile Leu Val
            340                 345                 350         
Asn Asn Leu Lys Lys Gly Thr Ile Pro Ser Leu Ser Ile Phe Thr Leu
        355                 360                 365             
Met Ile Phe Asp Glu Cys His Asn Thr Ser Lys Gln His Pro Tyr Asn
    370                 375                 380                 
Met Ile Met Phe Asn Tyr Leu Asp Gln Lys Leu Gly Gly Ser Ser Gly
385                 390                 395                 400 
Pro Leu Pro Gln Val Ile Gly Leu Thr Ala Ser Val Gly Val Gly Asp
                405                 410                 415     
Ala Lys Asn Thr Asp Glu Ala Leu Asp Tyr Ile Cys Lys Leu Cys Ala
            420                 425                 430         
Ser Leu Asp Ala Ser Val Ile Ala Thr Val Lys His Asn Leu Glu Glu
        435                 440                 445             
Leu Glu Gln Val Val Tyr Lys Pro Gln Lys Phe Phe Arg Lys Val Glu
    450                 455                 460                 
Ser Arg Ile Ser Asp Lys Phe Lys Tyr Ile Ile Ala Gln Leu Met Arg
465                 470                 475                 480 
Asp Thr Glu Ser Leu Ala Lys Arg Ile Cys Lys Asp Leu Glu Asn Leu
                485                 490                 495     
Ser Gln Ile Gln Asn Arg Glu Phe Gly Thr Gln Lys Tyr Glu Gln Trp
            500                 505                 510         
Ile Val Thr Val Gln Lys Ala Cys Met Val Phe Gln Met Pro Asp Lys
        515                 520                 525             
Asp Glu Glu Ser Arg Ile Cys Lys Ala Leu Phe Leu Tyr Thr Ser His
    530                 535                 540                 
Leu Arg Lys Tyr Asn Asp Ala Leu Ile Ile Ser Glu His Ala Arg Met
545                 550                 555                 560 
Lys Asp Ala Leu Asp Tyr Leu Lys Asp Phe Phe Ser Asn Val Arg Ala
                565                 570                 575     
Ala Gly Phe Asp Glu Ile Glu Gln Asp Leu Thr Gln Arg Phe Glu Glu
            580                 585                 590         
Lys Leu Gln Glu Leu Glu Ser Val Ser Arg Asp Pro Ser Asn Glu Asn
        595                 600                 605             
Pro Lys Leu Glu Asp Leu Cys Phe Ile Leu Gln Glu Glu Tyr His Leu
    610                 615                 620                 
Asn Pro Glu Thr Ile Thr Ile Leu Phe Val Lys Thr Arg Ala Leu Val
625                 630                 635                 640 
Asp Ala Leu Lys Asn Trp Ile Glu Gly Asn Pro Lys Leu Ser Phe Leu
                645                 650                 655     
Lys Pro Gly Ile Leu Thr Gly Arg Gly Lys Thr Asn Gln Asn Thr Gly
            660                 665                 670         
Met Thr Leu Pro Ala Gln Lys Cys Ile Leu Asp Ala Phe Lys Ala Ser
        675                 680                 685             
Gly Asp His Asn Ile Leu Ile Ala Thr Ser Val Ala Asp Glu Gly Ile
    690                 695                 700                 
Asp Ile Ala Gln Cys Asn Leu Val Ile Leu Tyr Glu Tyr Val Gly Asn
705                 710                 715                 720 
Val Ile Lys Met Ile Gln Thr Arg Gly Arg Gly Arg Ala Arg Gly Ser
                725                 730                 735     
Lys Cys Phe Leu Leu Thr Ser Asn Ala Gly Val Ile Glu Lys Glu Gln
            740                 745                 750         
Ile Asn Met Tyr Lys Glu Lys Met Met Asn Asp Ser Ile Leu Arg Leu
        755                 760                 765             
Gln Thr Trp Asp Glu Ala Val Phe Arg Glu Lys Ile Leu His Ile Gln
    770                 775                 780                 
Thr His Glu Lys Phe Ile Arg Asp Ser Gln Glu Lys Pro Lys Pro Val
785                 790                 795                 800 
Pro Asp Lys Glu Asn Lys Lys Leu Leu Cys Arg Lys Cys Lys Ala Leu
                805                 810                 815     
Ala Cys Tyr Thr Ala Asp Val Arg Val Ile Glu Glu Cys His Tyr Thr
            820                 825                 830         
Val Leu Gly Asp Ala Phe Lys Glu Cys Phe Val Ser Arg Pro His Pro
        835                 840                 845             
Lys Pro Lys Gln Phe Ser Ser Phe Glu Lys Arg Ala Lys Ile Phe Cys
    850                 855                 860                 
Ala Arg Gln Asn Cys Ser His Asp Trp Gly Ile His Val Lys Tyr Lys
865                 870                 875                 880 
Thr Phe Glu Ile Pro Val Ile Lys Ile Glu Ser Phe Val Val Glu Asp
                885                 890                 895     
Ile Ala Thr Gly Val Gln Thr Leu Tyr Ser Lys Trp Lys Asp Phe His
            900                 905                 910         
Phe Glu Lys Ile Pro Phe Asp Pro Ala Glu Met Ser Lys
        915                 920                 925 


<210> 2032
<211> 102
<212> PRT
<213> Homo sapiens

<400> 2032
Met Ser Gln Lys Ser Trp Asp Leu Leu Pro Ala Ala Ala Asp Ala Asp
 1               5                  10                  15      
Arg Pro Trp Glu Ala Ala Val Leu Trp Arg Ser Trp Ser Ser Ser Phe
            20                  25                  30          
Leu Gly Leu Ala Trp Leu Pro Gln Lys Glu Gln Ser Gly Leu Glu Gly
        35                  40                  45              
Ser Ile Lys Phe Tyr Thr His Lys Leu Gln Leu Glu Val Ser Phe Leu
    50                  55                  60                  
Lys Cys Pro Ala Phe Ala Gln Leu Phe Gln Ile Ile Ser Phe Leu Arg
65                  70                  75                  80  
Leu Trp Gln Val Ser Cys Pro Pro Ser Tyr Ser Ser Val Phe Thr Ser
                85                  90                  95      
Ser Arg Gln Gln Ser Gly
            100         


<210> 2033
<211> 999
<212> PRT
<213> Homo sapiens

<400> 2033
Met Val Cys Ser Pro Val Thr Val Arg Ile Ala Pro Pro Asp Arg Arg
 1               5                  10                  15      
Phe Ser Arg Ser Ala Ile Pro Glu Gln Ile Ile Ser Ser Thr Leu Ser
            20                  25                  30          
Ser Pro Ser Ser Asn Ala Pro Asp Pro Cys Ala Lys Glu Thr Val Leu
        35                  40                  45              
Ser Ala Leu Lys Glu Lys Glu Lys Lys Arg Thr Val Glu Glu Glu Asp
    50                  55                  60                  
Gln Ile Phe Leu Asp Gly Gln Glu Asn Lys Arg Arg Arg His Asp Ser
65                  70                  75                  80  
Ser Gly Ser Gly His Ser Ala Phe Glu Pro Leu Val Ala Asn Gly Val
                85                  90                  95      
Pro Ala Ser Phe Val Pro Lys Pro Gly Ser Leu Lys Arg Gly Leu Asn
            100                 105                 110         
Ser Gln Ser Ser Asp Asp His Leu Asn Lys Arg Ser Arg Ser Ser Ser
        115                 120                 125             
Met Ser Ser Leu Thr Gly Ala Tyr Ala Ser Gly Ile Pro Ser Ser Ser
    130                 135                 140                 
Arg Asn Ala Ile Thr Ser Ser Tyr Ser Ser Thr Arg Gly Ile Ser Gln
145                 150                 155                 160 
Leu Trp Lys Arg Asn Gly Pro Ser Ser Ser Pro Phe Ser Ser Pro Ala
                165                 170                 175     
Ser Ser Arg Ser Gln Thr Pro Glu Arg Pro Ala Lys Lys Ile Arg Glu
            180                 185                 190         
Glu Glu Leu Cys His His Ser Ser Ser Ser Thr Pro Leu Ala Ala Asp
        195                 200                 205             
Arg Glu Ser Gln Gly Glu Lys Ala Ala Asp Thr Thr Pro Arg Lys Lys
    210                 215                 220                 
Gln Asn Ser Asn Ser Gln Ser Thr Pro Gly Ser Ser Gly Gln Arg Lys
225                 230                 235                 240 
Arg Lys Val Gln Leu Leu Pro Ser Arg Arg Gly Glu Gln Leu Thr Leu
                245                 250                 255     
Pro Pro Pro Pro Gln Leu Gly Tyr Ser Ile Thr Ala Glu Asp Leu Asp
            260                 265                 270         
Leu Glu Lys Lys Ala Ser Leu Gln Trp Phe Asn Gln Ala Leu Glu Asp
        275                 280                 285             
Lys Ser Asp Ala Ala Ser Asn Ser Val Thr Glu Thr Pro Pro Ile Thr
    290                 295                 300                 
Gln Pro Ser Phe Thr Phe Thr Leu Pro Ala Ala Ala Pro Ala Ser Pro
305                 310                 315                 320 
Pro Thr Ser Leu Leu Ala Pro Ser Thr Asn Pro Leu Leu Glu Ser Leu
                325                 330                 335     
Lys Lys Met Gln Thr Pro Pro Ser Leu Pro Pro Cys Pro Glu Ser Ala
            340                 345                 350         
Gly Ala Ala Thr Thr Glu Ala Leu Ser Pro Pro Lys Thr Pro Ser Leu
        355                 360                 365             
Leu Pro Pro Leu Gly Leu Ser Gln Ser Gly Pro Pro Gly Leu Leu Pro
    370                 375                 380                 
Ser Pro Ser Phe Asp Ser Lys Pro Pro Thr Thr Leu Leu Gly Leu Ile
385                 390                 395                 400 
Pro Ala Pro Ser Met Val Pro Ala Thr Asp Thr Lys Ala Pro Pro Thr
                405                 410                 415     
Leu Gln Ala Glu Thr Ala Thr Lys Pro Gln Ala Thr Ser Ala Pro Ser
            420                 425                 430         
Pro Ala Pro Lys Gln Ser Phe Leu Phe Gly Thr Gln Asn Thr Ser Pro
        435                 440                 445             
Ser Ser Pro Ala Ala Pro Ala Ala Ser Ser Ala Pro Pro Met Phe Lys
    450                 455                 460                 
Pro Ile Phe Thr Ala Pro Pro Lys Ser Glu Lys Glu Gly Pro Thr Pro
465                 470                 475                 480 
Pro Gly Pro Ser Val Thr Ala Thr Ala Pro Ser Ser Ser Ser Leu Pro
                485                 490                 495     
Thr Thr Thr Ser Thr Thr Ala Pro Thr Phe Gln Pro Val Phe Ser Ser
            500                 505                 510         
Met Gly Pro Pro Ala Ser Val Pro Leu Pro Ala Pro Phe Phe Lys Gln
        515                 520                 525             
Thr Thr Thr Pro Ala Thr Ala Pro Thr Thr Thr Ala Pro Leu Phe Thr
    530                 535                 540                 
Gly Leu Ala Ser Ala Thr Ser Ala Val Ala Pro Ile Thr Ser Ala Ser
545                 550                 555                 560 
Pro Ser Thr Asp Ser Ala Ser Lys Pro Ala Phe Gly Phe Gly Ile Asn
                565                 570                 575     
Ser Val Ser Ser Ser Ser Val Ser Thr Thr Thr Ser Thr Ala Thr Ala
            580                 585                 590         
Ala Ser Gln Pro Phe Leu Phe Gly Ala Pro Gln Ala Ser Ala Ala Ser
        595                 600                 605             
Phe Thr Pro Ala Met Gly Ser Ile Phe Gln Phe Gly Lys Pro Pro Ala
    610                 615                 620                 
Leu Pro Thr Thr Thr Thr Val Thr Thr Phe Ser Gln Ser Leu His Thr
625                 630                 635                 640 
Ala Val Pro Thr Ala Thr Ser Ser Ser Ala Ala Asp Phe Ser Gly Phe
                645                 650                 655     
Gly Ser Thr Leu Ala Thr Ser Ala Pro Ala Thr Ser Ser Gln Pro Thr
            660                 665                 670         
Leu Thr Phe Ser Asn Thr Ser Thr Pro Thr Phe Asn Ile Pro Phe Gly
        675                 680                 685             
Ser Ser Ala Lys Ser Pro Leu Pro Ser Tyr Pro Gly Ala Asn Pro Gln
    690                 695                 700                 
Pro Ala Phe Gly Ala Ala Glu Gly Gln Pro Pro Gly Ala Ala Lys Pro
705                 710                 715                 720 
Ala Leu Ala Pro Ser Phe Gly Ser Ser Phe Thr Phe Gly Asn Ser Ala
                725                 730                 735     
Ala Pro Ala Ala Ala Pro Thr Pro Ala Pro Pro Ser Met Ile Lys Val
            740                 745                 750         
Val Pro Ala Tyr Val Pro Thr Pro Ile His Pro Ile Phe Gly Gly Ala
        755                 760                 765             
Thr His Ser Ala Phe Gly Leu Lys Ala Thr Ala Ser Ala Phe Gly Ala
    770                 775                 780                 
Pro Ala Ser Ser Gln Pro Ala Phe Gly Gly Ser Thr Ala Val Phe Phe
785                 790                 795                 800 
Gly Ala Ala Thr Ser Ser Gly Phe Gly Ala Thr Thr Gln Thr Ala Ser
                805                 810                 815     
Ser Gly Ser Ser Ser Ser Val Phe Gly Ser Thr Thr Pro Ser Pro Phe
            820                 825                 830         
Thr Phe Gly Gly Ser Ala Ala Pro Ala Gly Ser Gly Ser Phe Gly Ile
        835                 840                 845             
Asn Val Ala Thr Pro Gly Ser Ser Thr Thr Thr Gly Ala Phe Ser Phe
    850                 855                 860                 
Gly Ala Gly Gln Ser Gly Ser Thr Ala Thr Ser Thr Pro Phe Ala Gly
865                 870                 875                 880 
Gly Leu Gly Gln Asn Ala Leu Gly Thr Thr Gly Gln Ser Thr Pro Phe
                885                 890                 895     
Ala Phe Asn Val Ser Ser Thr Thr Glu Ser Lys Pro Val Phe Gly Gly
            900                 905                 910         
Thr Ala Thr Pro Thr Phe Gly Leu Asn Thr Pro Ala Pro Gly Val Gly
        915                 920                 925             
Thr Ser Gly Ser Ser Leu Ser Phe Gly Ala Ser Ser Ala Pro Ala Gln
    930                 935                 940                 
Gly Phe Val Gly Val Ala Pro Phe Gly Asn Thr Phe Ala His Gln Gln
945                 950                 955                 960 
Glu His Ser Pro Arg Lys Gly Pro Asn Asn Leu Ser Lys Arg Lys Leu
                965                 970                 975     
Leu Pro Ala Val Arg Ala Gln Gly Leu Pro Arg Arg Gly Gln Ala Ser
            980                 985                 990         
Ser Phe Pro Thr Arg Lys Glu
        995                 


<210> 2034
<211> 466
<212> PRT
<213> Homo sapiens

<400> 2034
Met Ser Thr Arg Ser Val Ser Ser Ser Ser Tyr Arg Arg Met Phe Gly
 1               5                  10                  15      
Gly Pro Gly Thr Ala Ser Arg Pro Ser Ser Ser Arg Ser Tyr Val Thr
            20                  25                  30          
Thr Ser Thr Arg Thr Tyr Ser Leu Gly Ser Ala Leu Arg Pro Ser Thr
        35                  40                  45              
Ser Arg Ser Leu Tyr Ala Ser Ser Pro Gly Gly Val Tyr Ala Thr Arg
    50                  55                  60                  
Ser Ser Ala Val Arg Leu Arg Ser Ser Val Pro Gly Val Arg Leu Leu
65                  70                  75                  80  
Gln Asp Ser Val Asp Phe Ser Leu Ala Asp Ala Ile Asn Thr Glu Phe
                85                  90                  95      
Lys Asn Thr Arg Thr Asn Glu Lys Val Glu Leu Gln Glu Leu Asn Asp
            100                 105                 110         
Arg Phe Ala Asn Tyr Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn
        115                 120                 125             
Lys Ile Leu Leu Ala Glu Leu Glu Gln Leu Lys Gly Gln Gly Lys Ser
    130                 135                 140                 
Arg Leu Gly Asp Leu Tyr Glu Glu Glu Met Arg Glu Leu Arg Arg Gln
145                 150                 155                 160 
Val Asp Gln Leu Thr Asn Asp Lys Ala Arg Val Glu Val Glu Arg Asp
                165                 170                 175     
Asn Leu Ala Glu Asp Ile Met Arg Leu Arg Glu Lys Leu Gln Glu Glu
            180                 185                 190         
Met Leu Gln Arg Glu Glu Ala Glu Asn Thr Leu Gln Ser Phe Arg Gln
        195                 200                 205             
Asp Val Asp Asn Ala Ser Leu Ala Arg Leu Asp Leu Glu Arg Lys Val
    210                 215                 220                 
Glu Ser Leu Gln Glu Glu Ile Ala Phe Leu Lys Lys Leu His Glu Glu
225                 230                 235                 240 
Glu Ile Gln Glu Leu Gln Ala Gln Ile Gln Glu Gln His Val Gln Ile
                245                 250                 255     
Asp Val Asp Val Ser Lys Pro Asp Leu Thr Ala Ala Leu Arg Asp Val
            260                 265                 270         
Arg Gln Gln Tyr Glu Ser Val Ala Ala Lys Asn Leu Gln Glu Ala Glu
        275                 280                 285             
Glu Trp Tyr Lys Ser Lys Phe Ala Asp Leu Ser Glu Ala Ala Asn Arg
    290                 295                 300                 
Asn Asn Asp Ala Leu Arg Gln Ala Lys Gln Glu Ser Thr Glu Tyr Arg
305                 310                 315                 320 
Arg Gln Val Gln Ser Leu Thr Cys Glu Val Asp Ala Leu Lys Gly Thr
                325                 330                 335     
Asn Glu Ser Leu Glu Arg Gln Met Arg Glu Met Glu Glu Asn Phe Ala
            340                 345                 350         
Val Glu Ala Ala Asn Tyr Gln Asp Thr Ile Gly Arg Leu Gln Asp Glu
        355                 360                 365             
Ile Gln Asn Met Lys Glu Glu Met Ala Arg His Leu Arg Glu Tyr Gln
    370                 375                 380                 
Asp Leu Leu Asn Val Lys Met Ala Leu Asp Ile Glu Ile Ala Thr Tyr
385                 390                 395                 400 
Arg Lys Leu Leu Glu Gly Glu Glu Ser Arg Ile Ser Leu Pro Leu Pro
                405                 410                 415     
Asn Phe Ser Ser Leu Asn Leu Arg Glu Thr Asn Leu Asp Ser Leu Pro
            420                 425                 430         
Leu Val Asp Thr His Ser Lys Arg Thr Leu Leu Ile Lys Thr Val Glu
        435                 440                 445             
Thr Arg Asp Gly Gln Val Ile Asn Glu Thr Ser Gln His His Asp Asp
    450                 455                 460                 
Leu Glu
465     


<210> 2035
<211> 489
<212> PRT
<213> Homo sapiens

<400> 2035
Met Glu Ser Met Phe Ser Ser Pro Ala Glu Ala Ala Leu Gln Arg Glu
 1               5                  10                  15      
Thr Gly Val Pro Gly Leu Leu Thr Pro Leu Pro Asp Leu Asp Gly Val
            20                  25                  30          
Tyr Glu Leu Glu Arg Val Ala Gly Phe Val Arg Asp Leu Gly Cys Glu
        35                  40                  45              
Arg Val Ala Leu Gln Phe Pro Asp Gln Leu Leu Gly Asp Ala Val Ala
    50                  55                  60                  
Val Ala Ala Arg Leu Glu Glu Thr Thr Gly Ser Lys Met Phe Ile Leu
65                  70                  75                  80  
Gly Asp Thr Ala Tyr Gly Ser Cys Cys Val Asp Val Leu Gly Ala Glu
                85                  90                  95      
Gln Ala Gly Ala Gln Ala Leu Ile His Phe Gly Pro Ala Cys Leu Ser
            100                 105                 110         
Pro Pro Ala Arg Pro Leu Pro Val Ala Phe Val Leu Arg Gln Arg Ser
        115                 120                 125             
Val Ala Leu Glu Leu Cys Val Lys Ala Phe Glu Ala Gln Asn Pro Asp
    130                 135                 140                 
Pro Lys Ala Pro Val Val Leu Leu Ser Glu Pro Ala Cys Ala His Ala
145                 150                 155                 160 
Leu Glu Ala Leu Ala Thr Leu Leu Arg Pro Arg Tyr Leu Asp Leu Leu
                165                 170                 175     
Val Ser Ser Pro Ala Phe Pro Gln Pro Val Gly Ser Leu Ser Pro Glu
            180                 185                 190         
Pro Met Pro Leu Glu Arg Phe Gly Arg Arg Phe Pro Leu Ala Pro Gly
        195                 200                 205             
Arg Arg Leu Glu Glu Tyr Gly Ala Phe Tyr Val Gly Gly Ser Lys Ala
    210                 215                 220                 
Ser Pro Asp Pro Asp Leu Asp Pro Asp Leu Ser Arg Leu Leu Leu Gly
225                 230                 235                 240 
Trp Ala Pro Gly Gln Pro Phe Ser Ser Cys Cys Pro Asp Thr Gly Lys
                245                 250                 255     
Thr Gln Asp Glu Gly Ala Arg Ala Gly Arg Leu Arg Ala Arg Arg Arg
            260                 265                 270         
Tyr Leu Val Glu Arg Ala Arg Asp Ala Arg Val Val Gly Leu Leu Ala
        275                 280                 285             
Gly Thr Leu Gly Val Ala Gln His Arg Glu Ala Leu Ala His Leu Arg
    290                 295                 300                 
Asn Leu Thr Gln Ala Ala Gly Lys Arg Ser Tyr Val Leu Ala Leu Gly
305                 310                 315                 320 
Arg Pro Thr Pro Ala Lys Leu Ala Asn Phe Pro Glu Val Asp Val Phe
                325                 330                 335     
Val Leu Leu Ala Cys Pro Leu Gly Ala Leu Ala Pro Gln Leu Ser Gly
            340                 345                 350         
Ser Phe Phe Gln Pro Ile Leu Ala Pro Cys Glu Leu Glu Ala Ala Cys
        355                 360                 365             
Asn Pro Ala Trp Pro Pro Pro Gly Leu Ala Pro His Leu Thr His Tyr
    370                 375                 380                 
Ala Asp Leu Leu Pro Gly Ser Pro Phe His Val Ala Leu Pro Pro Pro
385                 390                 395                 400 
Glu Ser Glu Leu Trp Glu Thr Pro Asp Val Ser Leu Ile Thr Gly Asp
                405                 410                 415     
Leu Arg Pro Pro Pro Ala Trp Lys Ser Ser Asn Asp His Gly Ser Leu
            420                 425                 430         
Ala Leu Thr Pro Arg Pro Gln Leu Glu Leu Ala Glu Ser Ser Pro Ala
        435                 440                 445             
Ala Ser Phe Leu Ser Ser Arg Ser Trp Gln Gly Leu Glu Pro Arg Leu
    450                 455                 460                 
Gly Gln Thr Pro Val Thr Glu Ala Val Ser Gly Arg Arg Gly Ile Ala
465                 470                 475                 480 
Ile Ala Tyr Glu Asp Glu Gly Ser Gly
                485                 


<210> 2036
<211> 946
<212> PRT
<213> Homo sapiens

<400> 2036
Met Lys Arg Leu Thr Cys Phe Phe Ile Cys Phe Phe Leu Ser Glu Val
 1               5                  10                  15      
Ser Gly Phe Glu Ile Pro Ile Asn Gly Leu Ser Glu Phe Val Asp Tyr
            20                  25                  30          
Glu Asp Leu Val Glu Leu Ala Pro Gly Lys Phe Gln Leu Val Ala Glu
        35                  40                  45              
Asn Arg Arg Tyr Gln Arg Ser Leu Pro Gly Glu Ser Glu Glu Met Met
    50                  55                  60                  
Glu Glu Val Asp Gln Val Thr Leu Tyr Ser Tyr Lys Val Gln Ser Thr
65                  70                  75                  80  
Ile Thr Ser Arg Met Ala Thr Thr Met Ile Gln Ser Lys Val Val Asn
                85                  90                  95      
Asn Ser Pro Gln Pro Gln Asn Val Val Phe Asp Val Gln Ile Pro Lys
            100                 105                 110         
Gly Ala Phe Ile Ser Asn Phe Ser Met Thr Val Asp Gly Lys Thr Phe
        115                 120                 125             
Arg Ser Ser Ile Lys Glu Lys Thr Val Gly Arg Ala Leu Tyr Ala Gln
    130                 135                 140                 
Ala Arg Ala Lys Gly Lys Thr Ala Gly Leu Val Arg Ser Ser Ala Leu
145                 150                 155                 160 
Asp Met Glu Asn Phe Arg Thr Glu Val Asn Val Leu Pro Gly Ala Lys
                165                 170                 175     
Val Gln Phe Glu Leu His Tyr Gln Glu Val Lys Trp Arg Lys Leu Gly
            180                 185                 190         
Ser Tyr Glu His Arg Ile Tyr Leu Gln Pro Gly Arg Leu Ala Lys His
        195                 200                 205             
Leu Glu Val Asp Val Trp Val Ile Glu Pro Gln Gly Leu Arg Phe Leu
    210                 215                 220                 
His Val Pro Asp Thr Phe Glu Gly His Phe Asp Gly Val Pro Val Ile
225                 230                 235                 240 
Ser Lys Gly Gln Gln Lys Ala His Val Ser Phe Lys Pro Thr Val Ala
                245                 250                 255     
Gln Gln Arg Ile Cys Pro Asn Cys Arg Glu Thr Ala Val Asp Gly Glu
            260                 265                 270         
Leu Val Val Leu Tyr Asp Val Lys Arg Glu Glu Lys Ala Gly Glu Leu
        275                 280                 285             
Glu Val Phe Asn Gly Tyr Phe Val His Phe Phe Ala Pro Asp Asn Leu
    290                 295                 300                 
Asp Pro Ile Pro Lys Asn Ile Leu Phe Val Ile Asp Val Ser Gly Ser
305                 310                 315                 320 
Met Trp Gly Val Lys Met Lys Gln Thr Val Glu Ala Met Lys Thr Ile
                325                 330                 335     
Leu Asp Asp Leu Arg Ala Glu Asp His Phe Ser Val Ile Asp Phe Asn
            340                 345                 350         
Gln Asn Ile Arg Thr Trp Arg Asn Asp Leu Ile Ser Ala Thr Lys Thr
        355                 360                 365             
Gln Val Ala Asp Ala Lys Arg Tyr Ile Glu Lys Ile Gln Pro Ser Gly
    370                 375                 380                 
Gly Thr Asn Ile Asn Glu Ala Leu Leu Arg Ala Ile Phe Ile Leu Asn
385                 390                 395                 400 
Glu Ala Asn Asn Leu Gly Leu Leu Asp Pro Asn Ser Val Ser Leu Ile
                405                 410                 415     
Ile Leu Val Ser Asp Gly Asp Pro Thr Val Gly Glu Leu Lys Leu Ser
            420                 425                 430         
Lys Ile Gln Lys Asn Val Lys Glu Asn Ile Gln Asp Asn Ile Ser Leu
        435                 440                 445             
Phe Ser Leu Gly Met Gly Phe Asp Val Asp Tyr Asp Phe Leu Lys Arg
    450                 455                 460                 
Leu Ser Asn Glu Asn His Gly Ile Ala Gln Arg Ile Tyr Gly Asn Gln
465                 470                 475                 480 
Asp Thr Ser Ser Gln Leu Lys Lys Phe Tyr Asn Gln Val Ser Thr Pro
                485                 490                 495     
Leu Leu Arg Asn Val Gln Phe Asn Tyr Pro His Thr Ser Val Thr Asp
            500                 505                 510         
Val Thr Gln Asn Asn Phe His Asn Tyr Phe Gly Gly Ser Glu Ile Val
        515                 520                 525             
Val Ala Gly Lys Phe Asp Pro Ala Lys Leu Asp Gln Ile Glu Ser Val
    530                 535                 540                 
Ile Thr Ala Thr Ser Ala Asn Thr Gln Leu Val Leu Glu Thr Leu Ala
545                 550                 555                 560 
Gln Met Asp Asp Leu Gln Asp Phe Leu Ser Lys Asp Lys His Ala Asp
                565                 570                 575     
Pro Asp Phe Thr Arg Lys Leu Trp Ala Tyr Leu Thr Ile Asn Gln Leu
            580                 585                 590         
Leu Ala Glu Arg Ser Leu Ala Pro Thr Ala Ala Ala Lys Arg Arg Ile
        595                 600                 605             
Thr Arg Ser Ile Leu Gln Met Ser Leu Asp His His Ile Val Thr Pro
    610                 615                 620                 
Leu Thr Ser Leu Val Ile Glu Asn Glu Ala Gly Asp Glu Arg Met Leu
625                 630                 635                 640 
Ala Asp Ala Pro Pro Gln Asp Pro Ser Cys Cys Ser Gly Ala Leu Tyr
                645                 650                 655     
Tyr Gly Ser Lys Val Val Pro Asp Ser Thr Pro Ser Trp Ala Asn Pro
            660                 665                 670         
Ser Pro Thr Pro Val Ile Ser Met Leu Ala Gln Gly Ser Gln Val Leu
        675                 680                 685             
Glu Ser Thr Pro Pro Pro His Val Met Arg Val Glu Asn Asp Pro His
    690                 695                 700                 
Phe Ile Ile Tyr Leu Pro Lys Ser Gln Lys Asn Ile Cys Phe Asn Ile
705                 710                 715                 720 
Asp Ser Glu Pro Gly Lys Ile Leu Asn Leu Val Ser Asp Pro Glu Ser
                725                 730                 735     
Gly Ile Val Val Asn Gly Gln Leu Val Gly Ala Lys Lys Pro Asn Asn
            740                 745                 750         
Gly Lys Leu Ser Thr Tyr Phe Gly Lys Leu Gly Phe Tyr Phe Gln Ser
        755                 760                 765             
Glu Asp Ile Lys Ile Glu Ile Ser Thr Glu Thr Ile Thr Leu Ser His
    770                 775                 780                 
Gly Ser Ser Thr Phe Ser Leu Ser Trp Ser Asp Thr Ala Gln Val Thr
785                 790                 795                 800 
Asn Gln Arg Val Gln Ile Ser Val Lys Lys Glu Lys Val Val Thr Ile
                805                 810                 815     
Thr Leu Asp Lys Glu Met Ser Phe Ser Val Leu Leu His Arg Val Trp
            820                 825                 830         
Lys Lys His Pro Val Asn Val Asp Phe Leu Gly Ile Tyr Ile Pro Pro
        835                 840                 845             
Thr Asn Lys Phe Ser Pro Lys Ala His Gly Leu Ile Gly Gln Phe Met
    850                 855                 860                 
Gln Glu Pro Lys Ile His Ile Phe Asn Glu Arg Pro Gly Lys Asp Pro
865                 870                 875                 880 
Glu Lys Pro Glu Ala Ser Met Glu Val Lys Gly Gln Lys Leu Ile Ile
                885                 890                 895     
Thr Arg Gly Leu Gln Lys Asp Tyr Arg Thr Asp Leu Val Phe Gly Thr
            900                 905                 910         
Asp Val Thr Cys Trp Phe Val His Asn Ser Gly Lys Gly Phe Ile Asp
        915                 920                 925             
Gly His Tyr Lys Asp Tyr Phe Val Pro Gln Leu Tyr Ser Phe Leu Lys
    930                 935                 940                 
Arg Pro
945     


<210> 2037
<211> 247
<212> PRT
<213> Homo sapiens

<400> 2037
Met Leu Val Leu Arg Ser Gly Leu Thr Lys Ala Leu Ala Ser Arg Thr
 1               5                  10                  15      
Leu Ala Pro Gln Val Cys Ser Ser Phe Ala Thr Gly Pro Arg Gln Tyr
            20                  25                  30          
Asp Gly Thr Phe Tyr Glu Phe Arg Thr Tyr Tyr Leu Lys Pro Ser Asn
        35                  40                  45              
Met Asn Ala Phe Met Glu Asn Leu Lys Lys Asn Ile His Leu Arg Thr
    50                  55                  60                  
Ser Tyr Ser Glu Leu Val Gly Phe Trp Ser Val Glu Phe Gly Gly Arg
65                  70                  75                  80  
Thr Asn Lys Val Phe His Ile Trp Lys Tyr Asp Asn Phe Ala His Arg
                85                  90                  95      
Ala Glu Val Arg Lys Ala Leu Ala Asn Cys Lys Glu Trp Gln Glu Gln
            100                 105                 110         
Ser Ile Ile Pro Asn Leu Ala Arg Ile Asp Lys Gln Glu Thr Glu Ile
        115                 120                 125             
Thr Tyr Leu Ile Pro Trp Ser Lys Leu Glu Lys Pro Pro Lys Glu Gly
    130                 135                 140                 
Val Tyr Glu Leu Ala Val Phe Gln Met Lys Pro Gly Gly Pro Ala Leu
145                 150                 155                 160 
Trp Gly Asp Ala Phe Glu Arg Ala Ile Asn Ala His Val Asn Leu Gly
                165                 170                 175     
Tyr Thr Lys Val Val Gly Val Phe His Thr Glu Tyr Gly Glu Leu Asn
            180                 185                 190         
Arg Val His Val Leu Trp Trp Asn Glu Ser Ala Asp Ser Arg Ala Ala
        195                 200                 205             
Gly Arg His Lys Ser His Glu Asp Pro Arg Val Val Ala Ala Val Arg
    210                 215                 220                 
Glu Ser Val Asn Tyr Leu Val Ser Gln Gln Asn Met Leu Leu Ile Pro
225                 230                 235                 240 
Ala Ser Phe Ser Pro Leu Lys
                245         


<210> 2038
<211> 1621
<212> PRT
<213> Homo sapiens

<400> 2038
Met Glu Trp Val Leu Ala Glu Ala Leu Leu Ser Gln Ser Arg Asp Pro
 1               5                  10                  15      
Arg Ala Leu Leu Gly Ala Leu Cys Gln Gly Glu Ala Ser Ala Glu Arg
            20                  25                  30          
Val Glu Thr Leu Arg Phe Leu Leu Gln Arg Leu Glu Asp Glu Glu Ala
        35                  40                  45              
Arg Gly Ser Gly Gly Ala Gly Ala Leu Pro Glu Ala Ala Arg Glu Val
    50                  55                  60                  
Ala Ala Gly Tyr Leu Val Pro Leu Leu Arg Ser Leu Arg Gly Arg Pro
65                  70                  75                  80  
Ala Gly Gly Pro Asp Pro Ser Met Gln Pro Pro His Arg Arg Arg Val
                85                  90                  95      
Leu Arg Ala Asn Ser Ser Ala Leu Arg Ser Cys Val Arg Leu Ala Gly
            100                 105                 110         
Arg Pro Gln Leu Ala Ala Ala Leu Ala Glu Glu Ala Leu Arg Asp Leu
        115                 120                 125             
Leu Ala Gly Trp Arg Ala Pro Gly Ala Glu Ala Ala Val Glu Val Leu
    130                 135                 140                 
Ala Ala Val Gly Pro Cys Leu Arg Pro Arg Glu Asp Gly Pro Leu Leu
145                 150                 155                 160 
Glu Arg Val Ala Gly Thr Ala Val Ala Leu Ala Leu Gly Gly Gly Gly
                165                 170                 175     
Asp Gly Asp Glu Ala Gly Pro Ala Glu Asp Ala Ala Ala Leu Val Ala
            180                 185                 190         
Gly Arg Leu Leu Pro Val Leu Val Gln Cys Gly Gly Ala Ala Leu Arg
        195                 200                 205             
Ala Val Trp Gly Gly Leu Ala Ala Pro Gly Ala Ser Leu Gly Ser Gly
    210                 215                 220                 
Arg Val Glu Glu Lys Leu Leu Val Leu Ser Ala Leu Ala Glu Lys Leu
225                 230                 235                 240 
Leu Pro Glu Pro Gly Gly Asp Arg Ala Arg Gly Ala Arg Glu Ala Gly
                245                 250                 255     
Pro Asp Ala Arg Arg Cys Trp Arg Phe Trp Arg Thr Val Gln Ala Gly
            260                 265                 270         
Leu Gly Gln Ala Asp Ala Leu Thr Arg Lys Arg Ala Arg Tyr Leu Leu
        275                 280                 285             
Gln Arg Ala Val Glu Val Ser Ala Glu Leu Gly Ala Asp Cys Thr Cys
    290                 295                 300                 
Gly Pro Gln Glu Gly Asn Gly Pro Ser Leu Phe Trp Trp Ser Glu Arg
305                 310                 315                 320 
Lys Lys Asp Glu Leu Leu Lys Phe Trp Glu Asn Tyr Ile Leu Ile Met
                325                 330                 335     
Glu Thr Leu Glu Gly Asn Gln Ile His Val Ile Lys Pro Val Leu Pro
            340                 345                 350         
Lys Leu Asn Asn Leu Phe Glu Tyr Ala Val Ser Glu Glu Asn Gly Cys
        355                 360                 365             
Trp Leu Phe His Pro Ser Trp His Met Cys Ile Tyr Lys Arg Met Phe
    370                 375                 380                 
Glu Ser Glu Asn Lys Ile Leu Ser Lys Glu Gly Val Ile His Phe Leu
385                 390                 395                 400 
Glu Leu Tyr Glu Thr Lys Ile Leu Pro Phe Ser Pro Glu Phe Ser Glu
                405                 410                 415     
Phe Ile Ile Gly Pro Leu Met Asp Ala Leu Ser Glu Ser Ser Leu Tyr
            420                 425                 430         
Ser Arg Ser Pro Gly Gln Pro Ile Gly Ser Cys Ser Pro Leu Gly Leu
        435                 440                 445             
Lys Leu Gln Lys Phe Leu Val Thr Tyr Ile Ser Leu Leu Pro Glu Glu
    450                 455                 460                 
Ile Lys Ser Ser Phe Leu Leu Lys Phe Ile Arg Lys Met Thr Ser Arg
465                 470                 475                 480 
His Trp Cys Ala Val Pro Ile Leu Phe Leu Ser Lys Ala Leu Ala Asn
                485                 490                 495     
Val Pro Arg His Lys Ala Leu Gly Ile Asp Gly Leu Leu Ala Leu Arg
            500                 505                 510         
Asp Val Ile His Cys Thr Met Ile Thr His Gln Ile Leu Leu Arg Gly
        515                 520                 525             
Ala Ala Gln Cys Tyr Leu Leu Gln Thr Ala Met Asn Leu Leu Asp Val
    530                 535                 540                 
Glu Lys Val Ser Leu Ser Asp Val Ser Thr Phe Leu Met Ser Leu Arg
545                 550                 555                 560 
Gln Glu Glu Ser Leu Gly Arg Gly Thr Ser Leu Trp Thr Glu Leu Cys
                565                 570                 575     
Asp Trp Leu Arg Val Asn Glu Ser Tyr Phe Lys Pro Ser Pro Thr Cys
            580                 585                 590         
Ser Ser Ile Gly Leu His Lys Thr Ser Leu Asn Ala Tyr Val Lys Ser
        595                 600                 605             
Ile Val Gln Glu Tyr Val Lys Ser Ser Ala Trp Glu Thr Gly Glu Asn
    610                 615                 620                 
Cys Phe Met Pro Asp Trp Phe Glu Ala Lys Leu Val Ser Leu Met Val
625                 630                 635                 640 
Leu Leu Ala Val Asp Val Glu Gly Met Lys Thr Gln Tyr Ser Gly Lys
                645                 650                 655     
Gln Arg Thr Glu Asn Val Leu Arg Ile Phe Leu Asp Pro Leu Leu Asp
            660                 665                 670         
Val Leu Met Lys Phe Ser Thr Asn Ala Tyr Met Pro Leu Leu Lys Thr
        675                 680                 685             
Asp Arg Cys Leu Gln Leu Leu Leu Lys Leu Leu Asn Thr Cys Arg Leu
    690                 695                 700                 
Lys Gly Ser Ser Ala Gln Asp Asp Glu Val Ser Thr Val Leu Gln Asn
705                 710                 715                 720 
Phe Phe Met Ser Thr Thr Glu Ser Ile Ser Glu Phe Ile Leu Arg Arg
                725                 730                 735     
Leu Thr Met Asn Glu Leu Asn Ser Val Ser Asp Leu Asp Arg Cys His
            740                 745                 750         
Leu Tyr Leu Met Val Leu Thr Glu Leu Ile Asn Leu His Leu Lys Val
        755                 760                 765             
Gly Trp Lys Arg Gly Asn Pro Ile Trp Arg Val Ile Ser Leu Leu Lys
    770                 775                 780                 
Asn Ala Ser Ile Gln His Leu Gln Glu Met Asp Ser Gly Gln Glu Pro
785                 790                 795                 800 
Thr Val Gly Ser Gln Ile Gln Arg Val Val Ser Met Ala Ala Leu Ala
                805                 810                 815     
Met Val Cys Glu Ala Ile Asp Gln Lys Pro Glu Leu Gln Leu Asp Ser
            820                 825                 830         
Leu His Ala Gly Pro Leu Glu Ser Phe Leu Ser Ser Leu Gln Leu Asn
        835                 840                 845             
Gln Thr Leu Gln Lys Pro His Ala Glu Glu Gln Ser Ser Tyr Ala His
    850                 855                 860                 
Pro Leu Glu Cys Ser Ser Val Leu Glu Glu Ser Ser Ser Ser Gln Gly
865                 870                 875                 880 
Trp Gly Lys Ile Val Ala Gln Tyr Ile His Asp Gln Trp Val Cys Leu
                885                 890                 895     
Ser Phe Leu Leu Lys Lys Tyr His Thr Leu Ile Pro Thr Thr Gly Ser
            900                 905                 910         
Glu Ile Leu Glu Pro Phe Leu Pro Ala Val Gln Met Pro Ile Arg Thr
        915                 920                 925             
Leu Gln Ser Ala Leu Glu Ala Leu Thr Val Leu Ser Ser Asp Gln Val
    930                 935                 940                 
Leu Pro Val Phe His Cys Leu Lys Val Leu Val Pro Lys Leu Leu Thr
945                 950                 955                 960 
Ser Ser Glu Ser Leu Cys Ile Glu Ser Phe Asp Met Ala Trp Lys Ile
                965                 970                 975     
Ile Ser Ser Leu Ser Asn Thr Gln Leu Ile Phe Trp Ala Asn Leu Lys
            980                 985                 990         
Ala Phe Val Gln Phe Val Phe Asp Asn Lys Val Leu Thr Ile Ala Ala
        995                 1000                1005            
Lys Ile Lys Gly Gln Ala Tyr Phe Lys Ile Lys Glu Ile Met Tyr Lys
    1010                1015                1020                
Ile Ile Glu Met Ser Ala Ile Lys Thr Gly Val Phe Asn Thr Leu Ile
1025                1030                1035                1040
Ser Tyr Cys Cys Gln Ser Trp Ile Val Ser Ala Ser Asn Val Ser Gln
                1045                1050                1055    
Gly Ser Leu Ser Ser Ala Lys Asn Tyr Ser Glu Leu Ile Leu Glu Ala
            1060                1065                1070        
Cys Ile Phe Gly Thr Val Phe Arg Arg Asp Gln Arg Leu Val Gln Asp
        1075                1080                1085            
Val Gln Thr Phe Ile Glu Asn Leu Gly His Asp Cys Ala Ala Asn Ile
    1090                1095                1100                
Val Met Glu Asn Thr Lys Arg Glu Asp His Tyr Val Arg Ile Cys Ala
1105                1110                1115                1120
Val Lys Phe Leu Cys Leu Leu Asp Gly Ser Asn Met Ser His Lys Leu
                1125                1130                1135    
Phe Ile Glu Asp Leu Ala Ile Lys Leu Leu Asp Lys Asp Glu Leu Val
            1140                1145                1150        
Ser Lys Ser Lys Lys Arg Tyr Tyr Val Asn Ser Leu Gln His Arg Val
        1155                1160                1165            
Lys Asn Arg Val Trp Gln Thr Leu Leu Val Leu Phe Pro Arg Leu Asp
    1170                1175                1180                
Gln Asn Phe Leu Asn Gly Ile Ile Asp Arg Ile Phe Gln Ala Gly Phe
1185                1190                1195                1200
Thr Asn Asn Gln Ala Ser Ile Lys Tyr Phe Ile Glu Trp Ile Ile Ile
                1205                1210                1215    
Leu Ile Leu His Lys Phe Pro Gln Phe Leu Pro Lys Phe Trp Asp Cys
            1220                1225                1230        
Phe Ser Tyr Gly Glu Glu Asn Leu Lys Thr Ser Ile Cys Thr Phe Leu
        1235                1240                1245            
Ala Val Leu Ser His Leu Asp Ile Ile Thr Gln Asn Ile Pro Glu Lys
    1250                1255                1260                
Lys Leu Ile Leu Lys Gln Ala Leu Ile Val Val Leu Gln Trp Cys Phe
1265                1270                1275                1280
Asn His Asn Phe Ser Val Arg Leu Tyr Ala Leu Val Ala Leu Lys Lys
                1285                1290                1295    
Leu Trp Thr Val Cys Lys Val Leu Ser Val Glu Glu Phe Asp Ala Leu
            1300                1305                1310        
Thr Pro Val Ile Glu Ser Ser Leu His Gln Val Glu Ser Met His Gly
        1315                1320                1325            
Ala Gly Asn Ala Lys Lys Asn Trp Gln Arg Ile Gln Glu His Phe Phe
    1330                1335                1340                
Phe Ala Thr Phe His Pro Leu Lys Asp Tyr Cys Leu Glu Thr Ile Phe
1345                1350                1355                1360
Tyr Ile Leu Pro Arg Leu Ser Gly Leu Ile Glu Asp Glu Trp Ile Thr
                1365                1370                1375    
Ile Asp Lys Phe Thr Arg Phe Thr Asp Val Pro Leu Ala Ala Gly Phe
            1380                1385                1390        
Gln Trp Tyr Leu Ser Gln Thr Gln Leu Ser Lys Leu Lys Pro Gly Asp
        1395                1400                1405            
Trp Ser Gln Gln Asp Ile Gly Thr Asn Leu Val Glu Ala Asp Asn Gln
    1410                1415                1420                
Ala Glu Trp Thr Asp Val Gln Lys Lys Ile Ile Pro Trp Asn Ser Arg
1425                1430                1435                1440
Val Ser Asp Leu Asp Leu Glu Leu Leu Phe Gln Asp Arg Ala Ala Arg
                1445                1450                1455    
Leu Gly Lys Ser Ile Ser Arg Leu Ile Val Val Ala Ser Leu Ile Asp
            1460                1465                1470        
Lys Pro Thr Asn Leu Gly Gly Leu Cys Arg Thr Cys Glu Val Phe Gly
        1475                1480                1485            
Ala Ser Val Leu Val Val Gly Ser Leu Gln Cys Ile Ser Asp Lys Gln
    1490                1495                1500                
Phe Gln His Leu Ser Val Ser Ala Glu Gln Trp Leu Pro Leu Val Glu
1505                1510                1515                1520
Val Lys Pro Pro Gln Leu Ile Asp Tyr Leu Gln Gln Lys Lys Thr Glu
                1525                1530                1535    
Gly Tyr Thr Ile Ile Gly Val Glu Gln Thr Ala Lys Ser Leu Asp Leu
            1540                1545                1550        
Thr Gln Tyr Cys Phe Pro Glu Lys Ser Leu Leu Leu Leu Gly Asn Glu
        1555                1560                1565            
Arg Glu Gly Ile Pro Ala Asn Leu Ile Gln Gln Leu Asp Val Cys Val
    1570                1575                1580                
Glu Ile Pro Gln Gln Gly Ile Ile Arg Ser Leu Asn Val His Val Ser
1585                1590                1595                1600
Gly Ala Leu Leu Ile Trp Glu Tyr Thr Arg Gln Gln Leu Leu Ser His
                1605                1610                1615    
Gly Asp Thr Lys Pro
            1620    


<210> 2039
<211> 2705
<212> PRT
<213> Homo sapiens

<400> 2039
Met Pro Ser Thr Glu Lys Asp Leu Ala Glu Asp Ala Pro Trp Lys Lys
 1               5                  10                  15      
Ile Gln Gln Asn Thr Phe Thr Arg Trp Cys Asn Glu His Leu Lys Cys
            20                  25                  30          
Val Gly Lys Arg Leu Thr Asp Leu Gln Arg Asp Leu Ser Asp Gly Leu
        35                  40                  45              
Arg Leu Ile Ala Leu Leu Glu Val Leu Ser Gln Lys Arg Met Tyr Arg
    50                  55                  60                  
Lys Phe His Pro Arg Pro Asn Phe Arg Gln Met Lys Leu Glu Asn Val
65                  70                  75                  80  
Ser Val Ala Leu Glu Phe Leu Glu Arg Glu His Ile Lys Leu Val Ser
                85                  90                  95      
Ile Asp Ser Lys Ala Ile Val Asp Gly Asn Leu Lys Leu Ile Leu Gly
            100                 105                 110         
Leu Ile Trp Thr Leu Ile Leu His Tyr Ser Ile Ser Met Pro Met Trp
        115                 120                 125             
Glu Asp Glu Asp Asp Glu Asp Ala Arg Lys Gln Thr Pro Lys Gln Arg
    130                 135                 140                 
Leu Leu Gly Trp Ile Gln Asn Lys Val Pro Gln Leu Pro Ile Thr Asn
145                 150                 155                 160 
Phe Asn Arg Asp Trp Gln Asp Gly Lys Ala Leu Gly Ala Leu Val Asp
                165                 170                 175     
Asn Cys Ala Pro Gly Leu Cys Pro Asp Trp Glu Ala Trp Asp Pro Asn
            180                 185                 190         
Gln Pro Val Glu Asn Ala Arg Glu Ala Met Gln Gln Ala Asp Asp Trp
        195                 200                 205             
Leu Gly Val Pro Gln Val Ile Ala Pro Glu Glu Ile Val Asp Pro Asn
    210                 215                 220                 
Val Asp Glu His Ser Val Met Thr Tyr Leu Ser Gln Phe Pro Lys Ala
225                 230                 235                 240 
Lys Leu Lys Pro Gly Ala Pro Val Arg Ser Lys Gln Leu Asn Pro Lys
                245                 250                 255     
Lys Ala Ile Ala Tyr Gly Pro Gly Ile Glu Pro Gln Gly Asn Thr Val
            260                 265                 270         
Leu Gln Pro Ala His Phe Thr Val Gln Thr Val Asp Ala Gly Val Gly
        275                 280                 285             
Glu Val Leu Val Tyr Ile Glu Asp Pro Glu Gly His Thr Glu Glu Ala
    290                 295                 300                 
Lys Val Val Pro Asn Asn Asp Lys Asp Arg Thr Tyr Ala Val Ser Tyr
305                 310                 315                 320 
Val Pro Lys Val Ala Gly Leu His Lys Val Thr Val Leu Phe Ala Gly
                325                 330                 335     
Gln Asn Ile Glu Arg Ser Pro Phe Glu Val Asn Val Gly Met Ala Leu
            340                 345                 350         
Gly Asp Ala Asn Lys Val Ser Ala Arg Gly Pro Gly Leu Glu Pro Val
        355                 360                 365             
Gly Asn Val Ala Asn Lys Pro Thr Tyr Phe Asp Ile Tyr Thr Ala Gly
    370                 375                 380                 
Ala Gly Thr Gly Asp Val Ala Val Val Ile Val Asp Pro Gln Gly Arg
385                 390                 395                 400 
Arg Asp Thr Val Glu Val Ala Leu Glu Asp Lys Gly Asp Ser Thr Phe
                405                 410                 415     
Arg Cys Thr Tyr Arg Pro Ala Met Glu Gly Pro His Thr Val His Val
            420                 425                 430         
Ala Phe Ala Gly Ala Pro Ile Thr Arg Ser Pro Phe Pro Val His Val
        435                 440                 445             
Ser Glu Ala Cys Asn Pro Asn Ala Cys Arg Ala Ser Gly Arg Gly Leu
    450                 455                 460                 
Gln Pro Lys Gly Val Arg Val Lys Glu Val Ala Asp Phe Lys Val Phe
465                 470                 475                 480 
Thr Lys Gly Ala Gly Ser Gly Glu Leu Lys Val Thr Val Lys Gly Pro
                485                 490                 495     
Lys Gly Thr Glu Glu Pro Val Lys Val Arg Glu Ala Gly Asp Gly Val
            500                 505                 510         
Phe Glu Cys Glu Tyr Tyr Pro Val Val Pro Gly Lys Tyr Val Val Thr
        515                 520                 525             
Ile Thr Trp Gly Gly Tyr Ala Ile Pro Arg Ser Pro Phe Glu Val Gln
    530                 535                 540                 
Val Ser Pro Glu Ala Gly Val Gln Lys Val Arg Ala Trp Gly Pro Gly
545                 550                 555                 560 
Leu Glu Thr Gly Gln Val Gly Lys Ser Ala Asp Phe Val Val Glu Ala
                565                 570                 575     
Ile Gly Thr Glu Val Gly Thr Leu Gly Phe Ser Ile Glu Gly Pro Ser
            580                 585                 590         
Gln Ala Lys Ile Glu Cys Asp Asp Lys Gly Asp Gly Ser Cys Asp Val
        595                 600                 605             
Arg Tyr Trp Pro Thr Glu Pro Gly Glu Tyr Ala Val His Val Ile Cys
    610                 615                 620                 
Asp Asp Glu Asp Ile Arg Asp Ser Pro Phe Ile Ala His Ile Leu Pro
625                 630                 635                 640 
Ala Pro Pro Asp Cys Phe Pro Asp Lys Val Lys Ala Phe Gly Pro Gly
                645                 650                 655     
Leu Glu Pro Thr Gly Cys Ile Val Asp Lys Pro Ala Glu Phe Thr Ile
            660                 665                 670         
Asp Ala Arg Ala Ala Gly Lys Gly Asp Leu Lys Leu Tyr Ala Gln Asp
        675                 680                 685             
Ala Asp Gly Cys Pro Ile Asp Ile Lys Val Ile Pro Asn Gly Asp Gly
    690                 695                 700                 
Thr Phe Arg Cys Ser Tyr Val Pro Thr Lys Pro Ile Lys His Thr Ile
705                 710                 715                 720 
Ile Ile Ser Trp Gly Gly Val Asn Val Pro Lys Ser Pro Phe Arg Val
                725                 730                 735     
Asn Val Gly Glu Gly Ser His Pro Glu Arg Val Lys Val Tyr Gly Pro
            740                 745                 750         
Gly Val Glu Lys Thr Gly Leu Lys Ala Asn Glu Pro Thr Tyr Phe Thr
        755                 760                 765             
Val Asp Cys Ser Glu Ala Gly Gln Gly Asp Val Ser Ile Gly Ile Lys
    770                 775                 780                 
Cys Ala Pro Gly Val Val Gly Pro Ala Glu Ala Asp Ile Asp Phe Asp
785                 790                 795                 800 
Ile Ile Lys Asn Asp Asn Asp Thr Phe Thr Val Lys Tyr Thr Pro Pro
                805                 810                 815     
Gly Ala Gly Arg Tyr Thr Ile Met Val Leu Phe Ala Asn Gln Glu Ile
            820                 825                 830         
Pro Ala Ser Pro Phe His Ile Lys Val Asp Pro Ser His Asp Ala Ser
        835                 840                 845             
Lys Val Lys Ala Glu Gly Pro Gly Leu Asn Arg Thr Gly Val Glu Val
    850                 855                 860                 
Gly Lys Pro Thr His Phe Thr Val Leu Thr Lys Gly Ala Gly Lys Ala
865                 870                 875                 880 
Lys Leu Asp Val Gln Phe Ala Gly Thr Ala Lys Gly Glu Val Val Arg
                885                 890                 895     
Asp Phe Glu Ile Ile Asp Asn His Asp Tyr Ser Tyr Thr Val Lys Tyr
            900                 905                 910         
Thr Ala Val Gln Gln Gly Asn Met Ala Val Thr Val Thr Tyr Gly Gly
        915                 920                 925             
Asp Pro Val Pro Lys Ser Pro Phe Val Val Asn Val Ala Pro Pro Leu
    930                 935                 940                 
Asp Leu Ser Lys Ile Lys Val Gln Gly Leu Asn Ser Lys Val Ala Val
945                 950                 955                 960 
Gly Gln Glu Gln Ala Phe Ser Val Asn Thr Arg Gly Ala Gly Gly Gln
                965                 970                 975     
Gly Gln Leu Asp Val Arg Met Thr Ser Pro Ser Arg Arg Pro Ile Pro
            980                 985                 990         
Cys Lys Leu Glu Pro Gly Gly Gly Ala Glu Ala Gln Ala Val Arg Tyr
        995                 1000                1005            
Met Pro Pro Glu Glu Gly Pro Tyr Lys Val Asp Ile Thr Tyr Asp Gly
    1010                1015                1020                
His Pro Val Pro Gly Ser Pro Phe Ala Val Glu Gly Val Leu Pro Pro
1025                1030                1035                1040
Asp Pro Ser Lys Val Cys Ala Tyr Gly Pro Gly Leu Lys Gly Gly Leu
                1045                1050                1055    
Val Gly Thr Pro Ala Pro Phe Ser Ile Asp Thr Lys Gly Ala Gly Thr
            1060                1065                1070        
Gly Gly Leu Gly Leu Thr Val Glu Gly Pro Cys Glu Ala Lys Ile Glu
        1075                1080                1085            
Cys Gln Asp Asn Gly Asp Gly Ser Cys Ala Val Ser Tyr Leu Pro Thr
    1090                1095                1100                
Glu Pro Gly Glu Tyr Thr Ile Asn Ile Leu Phe Ala Glu Ala His Ile
1105                1110                1115                1120
Pro Gly Ser Pro Phe Lys Ala Thr Ile Arg Pro Val Phe Asp Pro Ser
                1125                1130                1135    
Lys Val Arg Ala Ser Gly Pro Gly Leu Glu Arg Gly Lys Val Gly Glu
            1140                1145                1150        
Ala Ala Thr Phe Thr Val Asp Cys Ser Glu Ala Gly Glu Ala Glu Leu
        1155                1160                1165            
Thr Ile Glu Ile Leu Ser Asp Ala Gly Val Lys Ala Glu Val Leu Ile
    1170                1175                1180                
His Asn Asn Ala Asp Gly Thr Tyr His Ile Thr Tyr Ser Pro Ala Phe
1185                1190                1195                1200
Pro Gly Thr Tyr Thr Ile Thr Ile Lys Tyr Gly Gly His Pro Val Pro
                1205                1210                1215    
Lys Phe Pro Thr Arg Val His Val Gln Pro Ala Val Asp Thr Ser Gly
            1220                1225                1230        
Val Lys Val Ser Gly Pro Gly Val Glu Pro His Gly Val Leu Arg Glu
        1235                1240                1245            
Val Thr Thr Glu Phe Thr Val Asp Ala Arg Ser Leu Thr Ala Thr Gly
    1250                1255                1260                
Gly Asn His Val Thr Ala Arg Val Leu Asn Pro Ser Gly Ala Lys Thr
1265                1270                1275                1280
Asp Thr Tyr Val Thr Asp Asn Gly Asp Gly Thr Tyr Arg Val Gln Tyr
                1285                1290                1295    
Thr Ala Tyr Glu Glu Gly Val His Leu Val Glu Val Leu Tyr Asp Glu
            1300                1305                1310        
Val Ala Val Pro Lys Ser Pro Phe Arg Val Gly Val Thr Glu Gly Cys
        1315                1320                1325            
Asp Pro Thr Arg Val Arg Ala Phe Gly Pro Gly Leu Glu Gly Gly Leu
    1330                1335                1340                
Val Asn Lys Ala Asn Arg Phe Thr Val Glu Thr Arg Gly Ala Gly Thr
1345                1350                1355                1360
Gly Gly Leu Gly Leu Ala Ile Glu Gly Pro Ser Glu Ala Lys Met Ser
                1365                1370                1375    
Cys Lys Asp Asn Lys Asp Gly Ser Cys Thr Val Glu Tyr Ile Pro Phe
            1380                1385                1390        
Thr Pro Gly Asp Tyr Asp Val Asn Ile Thr Phe Gly Gly Arg Pro Ile
        1395                1400                1405            
Pro Gly Ser Pro Phe Arg Val Pro Val Lys Asp Val Val Asp Pro Gly
    1410                1415                1420                
Lys Val Lys Cys Ser Gly Pro Gly Leu Gly Ala Gly Val Arg Ala Arg
1425                1430                1435                1440
Val Pro Gln Thr Phe Thr Val Asp Cys Ser Gln Ala Gly Arg Ala Pro
                1445                1450                1455    
Leu Gln Val Ala Val Leu Gly Pro Thr Gly Val Ala Glu Pro Val Glu
            1460                1465                1470        
Val Arg Asp Asn Gly Asp Gly Thr His Thr Val His Tyr Thr Pro Ala
        1475                1480                1485            
Thr Asp Gly Pro Tyr Thr Val Ala Val Lys Tyr Ala Asp Gln Glu Val
    1490                1495                1500                
Pro Arg Ser Pro Phe Lys Ile Lys Val Leu Pro Ala His Asp Ala Ser
1505                1510                1515                1520
Lys Val Arg Ala Ser Gly Pro Gly Leu Asn Ala Ser Gly Ile Pro Ala
                1525                1530                1535    
Ser Leu Pro Val Glu Phe Thr Ile Asp Ala Arg Asp Ala Gly Glu Gly
            1540                1545                1550        
Leu Leu Thr Val Gln Ile Leu Asp Pro Glu Gly Lys Pro Lys Lys Ala
        1555                1560                1565            
Asn Ile Arg Asp Asn Gly Asp Gly Thr Tyr Thr Val Ser Tyr Leu Pro
    1570                1575                1580                
Asp Met Ser Gly Arg Tyr Thr Ile Thr Ile Lys Tyr Gly Gly Asp Glu
1585                1590                1595                1600
Ile Pro Tyr Ser Pro Phe Arg Ile His Ala Leu Pro Thr Gly Asp Ala
                1605                1610                1615    
Ser Lys Cys Leu Val Thr Val Ser Ile Gly Gly His Gly Leu Gly Ala
            1620                1625                1630        
Cys Leu Gly Pro Arg Ile Gln Ile Gly Gln Glu Thr Val Ile Thr Val
        1635                1640                1645            
Asp Ala Lys Ala Ala Gly Glu Gly Lys Val Thr Cys Thr Val Ser Thr
    1650                1655                1660                
Pro Asp Gly Ala Glu Leu Asp Val Asp Val Val Glu Asn His Asp Gly
1665                1670                1675                1680
Thr Phe Asp Ile Tyr Tyr Thr Ala Pro Glu Pro Gly Lys Tyr Val Ile
                1685                1690                1695    
Thr Ile Arg Phe Gly Gly Glu His Ile Pro Asn Ser Pro Phe His Val
            1700                1705                1710        
Leu Ala Cys Asp Pro Leu Pro His Glu Glu Glu Pro Ser Glu Val Pro
        1715                1720                1725            
Gln Leu Arg Gln Pro Tyr Ala Pro Pro Arg Pro Gly Ala Arg Pro Thr
    1730                1735                1740                
His Trp Ala Thr Glu Glu Pro Val Val Pro Val Glu Pro Met Glu Ser
1745                1750                1755                1760
Met Leu Arg Pro Phe Asn Leu Val Ile Pro Phe Ala Val Gln Lys Gly
                1765                1770                1775    
Glu Leu Thr Gly Glu Val Arg Met Pro Ser Gly Lys Thr Ala Arg Pro
            1780                1785                1790        
Asn Ile Thr Asp Asn Lys Asp Gly Thr Ile Thr Val Arg Tyr Ala Pro
        1795                1800                1805            
Thr Glu Lys Gly Leu His Gln Met Gly Ile Lys Tyr Asp Gly Asn His
    1810                1815                1820                
Ile Pro Gly Ser Pro Leu Gln Phe Tyr Val Asp Ala Ile Asn Ser Arg
1825                1830                1835                1840
His Val Ser Ala Tyr Gly Pro Gly Leu Ser His Gly Met Val Asn Lys
                1845                1850                1855    
Pro Ala Thr Phe Thr Ile Val Thr Lys Asp Ala Gly Glu Gly Gly Leu
            1860                1865                1870        
Ser Leu Ala Val Glu Gly Pro Ser Lys Ala Glu Ile Thr Cys Lys Asp
        1875                1880                1885            
Asn Lys Asp Gly Thr Cys Thr Val Ser Tyr Leu Pro Thr Ala Pro Gly
    1890                1895                1900                
Asp Tyr Ser Ile Ile Val Arg Phe Asp Asp Lys His Ile Pro Gly Ser
1905                1910                1915                1920
Pro Phe Thr Ala Lys Ile Thr Gly Asp Asp Ser Met Arg Thr Ser Gln
                1925                1930                1935    
Leu Asn Val Gly Thr Ser Thr Asp Val Ser Leu Lys Ile Thr Glu Ser
            1940                1945                1950        
Asp Leu Ser Gln Leu Thr Ala Ser Ile Arg Ala Pro Ser Gly Asn Glu
        1955                1960                1965            
Glu Pro Cys Leu Leu Lys Arg Leu Pro Asn Arg His Ile Gly Ile Ser
    1970                1975                1980                
Phe Thr Pro Lys Glu Val Gly Glu His Val Val Ser Val Arg Lys Ser
1985                1990                1995                2000
Gly Lys His Val Thr Asn Ser Pro Phe Lys Ile Leu Val Gly Pro Ser
                2005                2010                2015    
Glu Ile Gly Asp Ala Ser Lys Val Arg Val Trp Gly Lys Gly Leu Ser
            2020                2025                2030        
Glu Gly His Thr Phe Gln Val Ala Glu Phe Ile Val Asp Thr Arg Asn
        2035                2040                2045            
Ala Gly Tyr Gly Gly Leu Gly Leu Ser Ile Glu Gly Pro Ser Lys Val
    2050                2055                2060                
Asp Ile Asn Cys Glu Asp Met Glu Asp Gly Thr Cys Lys Val Thr Tyr
2065                2070                2075                2080
Cys Pro Thr Glu Pro Gly Thr Tyr Ile Ile Asn Ile Lys Phe Ala Asp
                2085                2090                2095    
Lys His Val Pro Gly Ser Pro Phe Thr Val Lys Val Thr Gly Glu Gly
            2100                2105                2110        
Arg Met Lys Glu Ser Ile Thr Arg Arg Arg Gln Ala Pro Ser Ile Ala
        2115                2120                2125            
Thr Ile Gly Ser Thr Cys Asp Leu Asn Leu Lys Ile Pro Gly Asn Trp
    2130                2135                2140                
Phe Gln Met Val Ser Ala Gln Glu Arg Leu Thr Arg Thr Phe Thr Arg
2145                2150                2155                2160
Ser Ser His Thr Tyr Thr Arg Thr Glu Arg Thr Glu Ile Ser Lys Thr
                2165                2170                2175    
Arg Gly Gly Glu Thr Lys Arg Glu Val Arg Val Glu Glu Ser Thr Gln
            2180                2185                2190        
Val Gly Gly Asp Pro Phe Pro Ala Val Phe Gly Asp Phe Leu Gly Arg
        2195                2200                2205            
Glu Arg Leu Gly Ser Phe Gly Ser Ile Thr Arg Gln Gln Glu Gly Glu
    2210                2215                2220                
Ala Ser Ser Gln Asp Met Thr Ala Gln Val Thr Ser Pro Ser Gly Lys
2225                2230                2235                2240
Val Glu Ala Ala Glu Ile Val Glu Gly Glu Asp Ser Ala Tyr Ser Val
                2245                2250                2255    
Arg Phe Val Pro Gln Glu Met Gly Pro His Thr Val Ala Val Lys Tyr
            2260                2265                2270        
Arg Gly Gln His Val Pro Gly Ser Pro Phe Gln Phe Thr Val Gly Pro
        2275                2280                2285            
Leu Gly Glu Gly Gly Ala His Lys Val Arg Ala Gly Gly Thr Gly Leu
    2290                2295                2300                
Glu Arg Gly Val Ala Gly Val Pro Ala Glu Phe Ser Ile Trp Thr Arg
2305                2310                2315                2320
Glu Ala Gly Ala Gly Gly Leu Ser Ile Ala Val Glu Gly Pro Ser Lys
                2325                2330                2335    
Ala Glu Ile Ala Phe Glu Asp Arg Lys Asp Gly Ser Cys Gly Val Ser
            2340                2345                2350        
Tyr Val Val Gln Glu Pro Gly Asp Tyr Glu Val Ser Ile Lys Phe Asn
        2355                2360                2365            
Asp Glu His Ile Pro Asp Ser Pro Phe Val Val Pro Val Ala Ser Leu
    2370                2375                2380                
Ser Asp Asp Ala Arg Arg Leu Thr Val Thr Ser Leu Gln Glu Thr Gly
2385                2390                2395                2400
Leu Lys Val Asn Gln Pro Ala Ser Phe Ala Val Gln Leu Asn Gly Ala
                2405                2410                2415    
Arg Gly Val Ile Asp Ala Arg Val His Thr Pro Ser Gly Ala Val Glu
            2420                2425                2430        
Glu Cys Tyr Val Ser Glu Leu Asp Ser Asp Lys His Thr Ile Arg Phe
        2435                2440                2445            
Ile Pro His Glu Asn Gly Val His Ser Ile Asp Val Lys Phe Asn Gly
    2450                2455                2460                
Ala His Ile Pro Gly Ser Pro Phe Lys Ile Arg Val Gly Glu Gln Ser
2465                2470                2475                2480
Gln Ala Gly Asp Pro Gly Leu Val Ser Ala Tyr Gly Pro Gly Leu Glu
                2485                2490                2495    
Gly Gly Thr Thr Gly Val Ser Ser Glu Phe Ile Val Asn Thr Leu Asn
            2500                2505                2510        
Ala Gly Ser Gly Ala Leu Ser Val Thr Ile Asp Gly Pro Ser Lys Val
        2515                2520                2525            
Gln Leu Asp Cys Arg Glu Cys Pro Glu Gly His Val Val Thr Tyr Thr
    2530                2535                2540                
Pro Met Ala Pro Gly Asn Tyr Leu Ile Ala Ile Lys Tyr Gly Gly Pro
2545                2550                2555                2560
Gln His Ile Val Gly Ser Pro Phe Lys Ala Lys Val Thr Gly Pro Arg
                2565                2570                2575    
Leu Ser Gly Gly His Ser Leu His Glu Thr Ser Thr Val Leu Val Glu
            2580                2585                2590        
Thr Val Thr Lys Ser Ser Ser Ser Arg Gly Ser Ser Tyr Ser Ser Ile
        2595                2600                2605            
Pro Lys Phe Ser Ser Asp Ala Ser Lys Val Val Thr Arg Gly Pro Gly
    2610                2615                2620                
Leu Ser Gln Ala Phe Val Gly Gln Lys Asn Ser Phe Thr Val Asp Cys
2625                2630                2635                2640
Ser Lys Ala Gly Thr Asn Met Met Met Val Gly Val His Gly Pro Lys
                2645                2650                2655    
Thr Pro Cys Glu Glu Val Tyr Val Lys His Met Gly Asn Arg Val Tyr
            2660                2665                2670        
Asn Val Thr Tyr Thr Val Lys Glu Lys Gly Asp Tyr Ile Leu Ile Val
        2675                2680                2685            
Lys Trp Gly Asp Glu Ser Val Pro Gly Ser Pro Phe Lys Val Lys Val
    2690                2695                2700                
Pro
2705


<210> 2040
<211> 654
<212> PRT
<213> Homo sapiens

<400> 2040
Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Ala Ala
 1               5                  10                  15      
Arg Ala Glu Glu Glu Asp Lys Lys Glu Asp Val Gly Thr Val Val Gly
            20                  25                  30          
Ile Asp Leu Gly Thr Thr Tyr Ser Cys Val Gly Val Phe Lys Asn Gly
        35                  40                  45              
Arg Val Glu Ile Ile Ala Asn Asp Gln Gly Asn Arg Ile Thr Pro Ser
    50                  55                  60                  
Tyr Val Ala Phe Thr Pro Glu Gly Glu Arg Leu Ile Gly Asp Ala Ala
65                  70                  75                  80  
Lys Asn Gln Leu Thr Ser Asn Pro Glu Asn Thr Val Phe Asp Ala Lys
                85                  90                  95      
Arg Leu Ile Gly Arg Thr Trp Asn Asp Pro Ser Val Gln Gln Asp Ile
            100                 105                 110         
Lys Phe Leu Pro Phe Lys Val Val Glu Lys Lys Thr Lys Pro Tyr Ile
        115                 120                 125             
Gln Val Asp Ile Gly Gly Gly Gln Thr Lys Thr Phe Ala Pro Glu Glu
    130                 135                 140                 
Ile Ser Ala Met Val Leu Thr Lys Met Lys Glu Thr Ala Glu Ala Tyr
145                 150                 155                 160 
Leu Gly Lys Lys Val Thr His Ala Val Val Thr Val Pro Ala Tyr Phe
                165                 170                 175     
Asn Asp Ala Gln Arg Gln Ala Thr Lys Asp Ala Gly Thr Ile Ala Gly
            180                 185                 190         
Leu Asn Val Met Arg Ile Ile Asn Glu Pro Thr Ala Ala Ala Ile Ala
        195                 200                 205             
Tyr Gly Leu Asp Lys Arg Glu Gly Glu Lys Asn Ile Leu Val Phe Asp
    210                 215                 220                 
Leu Gly Gly Gly Thr Phe Asp Val Ser Leu Leu Thr Ile Asp Asn Gly
225                 230                 235                 240 
Val Phe Glu Val Val Ala Thr Asn Gly Asp Thr His Leu Gly Gly Glu
                245                 250                 255     
Asp Phe Asp Gln Arg Val Met Glu His Phe Ile Lys Leu Tyr Lys Lys
            260                 265                 270         
Lys Thr Gly Lys Asp Val Arg Lys Asp Asn Arg Ala Val Gln Lys Leu
        275                 280                 285             
Arg Arg Glu Val Glu Lys Ala Lys Arg Ala Leu Ser Ser Gln His Gln
    290                 295                 300                 
Ala Arg Ile Glu Ile Glu Ser Phe Tyr Glu Gly Glu Asp Phe Ser Glu
305                 310                 315                 320 
Thr Leu Thr Arg Ala Lys Phe Glu Glu Leu Asn Met Asp Leu Phe Arg
                325                 330                 335     
Ser Thr Met Lys Pro Val Gln Lys Val Leu Glu Asp Ser Asp Leu Lys
            340                 345                 350         
Lys Ser Asp Ile Asp Glu Ile Val Leu Val Gly Gly Ser Thr Arg Ile
        355                 360                 365             
Pro Lys Ile Gln Gln Leu Val Lys Glu Phe Phe Asn Gly Lys Glu Pro
    370                 375                 380                 
Ser Arg Gly Ile Asn Pro Asp Glu Ala Val Ala Tyr Gly Ala Ala Val
385                 390                 395                 400 
Gln Ala Gly Val Leu Ser Gly Asp Gln Asp Thr Gly Asp Leu Val Leu
                405                 410                 415     
Leu Asp Val Cys Pro Leu Thr Leu Gly Ile Glu Thr Val Gly Gly Val
            420                 425                 430         
Met Thr Lys Leu Ile Pro Arg Asn Thr Val Val Pro Thr Lys Lys Ser
        435                 440                 445             
Gln Ile Phe Ser Thr Ala Ser Asp Asn Gln Pro Thr Val Thr Ile Lys
    450                 455                 460                 
Val Tyr Glu Gly Glu Arg Pro Leu Thr Lys Asp Asn His Leu Leu Gly
465                 470                 475                 480 
Thr Phe Asp Leu Thr Gly Ile Pro Pro Ala Pro Arg Gly Val Pro Gln
                485                 490                 495     
Ile Glu Val Thr Phe Glu Ile Asp Val Asn Gly Ile Leu Arg Val Thr
            500                 505                 510         
Ala Glu Asp Lys Gly Thr Gly Asn Lys Asn Lys Ile Thr Ile Thr Asn
        515                 520                 525             
Asp Gln Asn Arg Leu Thr Pro Glu Glu Ile Glu Arg Met Val Asn Asp
    530                 535                 540                 
Ala Glu Lys Phe Ala Glu Glu Asp Lys Lys Leu Lys Glu Arg Ile Asp
545                 550                 555                 560 
Thr Arg Asn Glu Leu Glu Ser Tyr Ala Tyr Ser Leu Lys Asn Gln Ile
                565                 570                 575     
Gly Asp Lys Glu Lys Leu Gly Gly Lys Leu Ser Ser Glu Asp Lys Glu
            580                 585                 590         
Thr Met Glu Lys Ala Val Glu Glu Lys Ile Glu Trp Leu Glu Ser His
        595                 600                 605             
Gln Asp Ala Asp Ile Glu Asp Phe Lys Ala Lys Lys Lys Glu Leu Glu
    610                 615                 620                 
Glu Ile Val Gln Pro Ile Ile Ser Lys Leu Tyr Gly Ser Ala Gly Pro
625                 630                 635                 640 
Pro Pro Thr Gly Glu Glu Asp Thr Ala Glu Lys Asp Glu Leu
                645                 650                 


<210> 2041
<211> 480
<212> PRT
<213> Homo sapiens

<400> 2041
Met Glu Arg Asp Glu Pro Pro Pro Ser Gly Gly Gly Gly Gly Gly Gly
 1               5                  10                  15      
Ser Ala Gly Phe Leu Glu Pro Pro Ala Ala Leu Pro Pro Pro Pro Arg
            20                  25                  30          
Asn Gly Phe Cys Gln Asp Glu Leu Ala Glu Leu Asp Pro Gly Thr Ile
        35                  40                  45              
Ser Val Ser Asp Asp Arg Ala Glu Gln Arg Thr Cys Leu Ile Cys Gly
    50                  55                  60                  
Asp Arg Ala Thr Gly Leu His Tyr Gly Ile Ile Ser Cys Glu Gly Cys
65                  70                  75                  80  
Lys Gly Phe Phe Lys Arg Ser Ile Cys Asn Lys Arg Val Tyr Arg Cys
                85                  90                  95      
Ser Arg Asp Lys Asn Cys Val Met Ser Arg Lys Gln Arg Asn Arg Cys
            100                 105                 110         
Gln Tyr Cys Arg Leu Leu Lys Cys Leu Gln Met Gly Met Asn Arg Lys
        115                 120                 125             
Ala Ile Arg Glu Asp Gly Met Pro Gly Gly Arg Asn Lys Ser Ile Gly
    130                 135                 140                 
Pro Val Gln Ile Ser Glu Glu Glu Ile Glu Arg Ile Met Ser Gly Gln
145                 150                 155                 160 
Glu Phe Glu Glu Glu Ala Asn His Trp Ser Asn His Gly Asp Ser Asp
                165                 170                 175     
His Ser Ser Pro Gly Asn Arg Ala Ser Glu Ser Asn Gln Pro Ser Pro
            180                 185                 190         
Gly Ser Thr Leu Ser Ser Ser Arg Ser Val Glu Leu Asn Gly Phe Met
        195                 200                 205             
Ala Phe Arg Glu Gln Tyr Met Gly Met Ser Val Pro Pro His Tyr Gln
    210                 215                 220                 
Tyr Ile Pro His Leu Phe Ser Tyr Ser Gly His Ser Pro Leu Leu Pro
225                 230                 235                 240 
Gln Gln Ala Arg Ser Leu Asp Pro Gln Ser Tyr Ser Leu Ile His Gln
                245                 250                 255     
Leu Leu Ser Ala Glu Asp Leu Glu Pro Leu Gly Thr Pro Met Leu Ile
            260                 265                 270         
Glu Asp Gly Tyr Ala Val Thr Gln Ala Glu Leu Phe Ala Leu Leu Cys
        275                 280                 285             
Arg Leu Ala Asp Glu Leu Leu Phe Arg Gln Ile Ala Trp Ile Lys Lys
    290                 295                 300                 
Leu Pro Phe Phe Cys Glu Leu Ser Ile Lys Asp Tyr Thr Cys Leu Leu
305                 310                 315                 320 
Ser Ser Thr Trp Gln Glu Leu Ile Leu Leu Ser Ser Leu Thr Val Tyr
                325                 330                 335     
Ser Lys Gln Ile Phe Gly Glu Leu Ala Asp Val Thr Ala Lys Tyr Ser
            340                 345                 350         
Pro Ser Asp Glu Glu Leu His Arg Phe Ser Asp Glu Gly Met Glu Val
        355                 360                 365             
Ile Glu Arg Leu Ile Tyr Leu Tyr His Lys Phe His Gln Leu Lys Val
    370                 375                 380                 
Ser Asn Glu Glu Tyr Ala Cys Met Lys Ala Ile Asn Phe Leu Asn Gln
385                 390                 395                 400 
Asp Ile Arg Gly Leu Thr Ser Ala Ser Gln Leu Glu Gln Leu Asn Lys
                405                 410                 415     
Arg Tyr Trp Tyr Ile Cys Gln Asp Phe Thr Glu Tyr Lys Tyr Thr His
            420                 425                 430         
Gln Pro Asn Arg Phe Pro Asp Leu Met Met Cys Leu Pro Glu Ile Arg
        435                 440                 445             
Tyr Ile Ala Gly Lys Met Val Asn Val Pro Leu Glu Gln Leu Pro Leu
    450                 455                 460                 
Leu Phe Lys Val Val Leu His Ser Cys Lys Thr Ser Val Gly Lys Glu
465                 470                 475                 480 


<210> 2042
<211> 700
<212> PRT
<213> Homo sapiens

<400> 2042
Met Lys Cys Val Leu Val Ala Thr Glu Gly Ala Glu Val Leu Phe Tyr
 1               5                  10                  15      
Trp Thr Asp Gln Glu Phe Glu Glu Ser Leu Arg Leu Lys Phe Gly Gln
            20                  25                  30          
Ser Glu Asn Glu Glu Glu Glu Leu Pro Ala Leu Glu Asp Gln Leu Ser
        35                  40                  45              
Thr Leu Leu Ala Pro Val Ile Ile Ser Ser Met Thr Met Leu Glu Lys
    50                  55                  60                  
Leu Ser Asp Thr Tyr Thr Cys Phe Ser Thr Glu Asn Gly Asn Phe Leu
65                  70                  75                  80  
Tyr Val Leu His Leu Phe Gly Glu Cys Leu Phe Ile Ala Ile Asn Gly
                85                  90                  95      
Asp His Thr Glu Ser Glu Gly Asp Leu Arg Arg Lys Leu Tyr Val Leu
            100                 105                 110         
Lys Tyr Leu Phe Glu Val His Phe Gly Leu Val Thr Val Asp Gly His
        115                 120                 125             
Leu Ile Arg Lys Glu Leu Arg Pro Pro Asp Leu Ala Gln Arg Val Gln
    130                 135                 140                 
Leu Trp Glu His Phe Gln Ser Leu Leu Trp Thr Tyr Ser Arg Leu Arg
145                 150                 155                 160 
Glu Gln Glu Gln Cys Phe Ala Val Glu Ala Leu Glu Arg Leu Ile His
                165                 170                 175     
Pro Gln Leu Cys Glu Leu Cys Ile Glu Ala Leu Glu Arg His Val Ile
            180                 185                 190         
Gln Ala Val Asn Thr Ser Pro Glu Arg Gly Gly Glu Glu Ala Leu His
        195                 200                 205             
Ala Phe Leu Leu Val His Ser Lys Leu Leu Ala Phe Tyr Ser Ser His
    210                 215                 220                 
Ser Ala Ser Ser Leu Arg Pro Ala Asp Leu Leu Ala Leu Ile Leu Leu
225                 230                 235                 240 
Val Gln Asp Leu Tyr Pro Ser Glu Ser Thr Ala Glu Asp Asp Ile Gln
                245                 250                 255     
Pro Ser Pro Arg Arg Ala Arg Ser Ser Gln Asn Ile Pro Val Gln Gln
            260                 265                 270         
Ala Trp Ser Pro His Ser Thr Gly Pro Thr Gly Gly Ser Ser Ala Glu
        275                 280                 285             
Thr Glu Thr Asp Ser Phe Ser Leu Pro Glu Glu Tyr Phe Thr Pro Ala
    290                 295                 300                 
Pro Ser Pro Gly Asp Gln Ser Ser Gly Ser Thr Ile Trp Leu Glu Gly
305                 310                 315                 320 
Gly Thr Pro Pro Met Asp Ala Leu Gln Ile Ala Glu Asp Thr Leu Gln
                325                 330                 335     
Thr Leu Val Pro His Cys Pro Val Pro Ser Gly Pro Arg Arg Ile Phe
            340                 345                 350         
Leu Asp Ala Asn Val Lys Glu Ser Tyr Cys Pro Leu Val Pro His Thr
        355                 360                 365             
Met Tyr Cys Leu Pro Leu Trp Gln Gly Ile Asn Leu Val Leu Leu Thr
    370                 375                 380                 
Arg Ser Pro Ser Ala Pro Leu Ala Leu Val Leu Ser Gln Leu Met Asp
385                 390                 395                 400 
Gly Phe Ser Met Leu Glu Lys Lys Leu Lys Glu Gly Pro Glu Pro Gly
                405                 410                 415     
Ala Ser Leu Arg Ser Gln Pro Leu Val Gly Asp Leu Arg Gln Arg Met
            420                 425                 430         
Asp Lys Phe Val Lys Asn Arg Gly Ala Gln Glu Ile Gln Ser Thr Trp
        435                 440                 445             
Leu Glu Phe Lys Ala Lys Ala Phe Ser Lys Ser Glu Pro Gly Ser Ser
    450                 455                 460                 
Trp Glu Leu Leu Gln Ala Cys Gly Lys Leu Lys Arg Gln Leu Cys Ala
465                 470                 475                 480 
Ile Tyr Arg Leu Asn Phe Leu Thr Thr Ala Pro Ser Arg Gly Gly Pro
                485                 490                 495     
His Leu Pro Gln His Leu Gln Asp Gln Val Gln Arg Leu Met Arg Glu
            500                 505                 510         
Lys Leu Thr Asp Trp Lys Asp Phe Leu Leu Val Lys Ser Arg Arg Asn
        515                 520                 525             
Ile Thr Met Val Ser Tyr Leu Glu Asp Phe Pro Gly Leu Val His Phe
    530                 535                 540                 
Ile Tyr Val Asp Arg Thr Thr Gly Gln Met Val Ala Pro Ser Leu Asn
545                 550                 555                 560 
Cys Ser Gln Lys Thr Ser Ser Glu Leu Gly Lys Gly Pro Leu Ala Ala
                565                 570                 575     
Phe Val Lys Thr Lys Val Trp Ser Leu Ile Gln Leu Ala Arg Arg Tyr
            580                 585                 590         
Leu Gln Lys Gly Tyr Thr Thr Leu Leu Phe Gln Glu Gly Asp Phe Tyr
        595                 600                 605             
Cys Ser Tyr Phe Leu Trp Phe Glu Asn Asp Met Gly Tyr Lys Leu Gln
    610                 615                 620                 
Met Ile Glu Val Pro Val Leu Ser Asp Asp Ser Val Pro Ile Gly Met
625                 630                 635                 640 
Leu Gly Gly Asp Tyr Tyr Arg Lys Leu Leu Arg Tyr Tyr Ser Lys Asn
                645                 650                 655     
Arg Pro Thr Glu Ala Val Arg Cys Tyr Glu Leu Leu Ala Leu His Leu
            660                 665                 670         
Ser Val Ile Pro Thr Asp Leu Leu Val Gln Gln Ala Gly Gln Leu Ala
        675                 680                 685             
Arg Arg Leu Trp Glu Ala Ser Arg Ile Pro Leu Leu
    690                 695                 700 


<210> 2043
<211> 363
<212> PRT
<213> Homo sapiens

<400> 2043
Met Glu Leu Phe Gln Asp Ser Gly Asn Thr Asp Ile Glu Gly Ile Asp
 1               5                  10                  15      
Thr Thr Asn Ala Cys Tyr Gly Gly Thr Ala Ser Leu Phe Asn Ala Ala
            20                  25                  30          
Asn Trp Met Glu Ser Ser Ser Trp Asp Gly Arg Tyr Ala Met Val Val
        35                  40                  45              
Cys Gly Asp Ile Ala Val Tyr Pro Ser Gly Asn Ala Arg Pro Thr Gly
    50                  55                  60                  
Gly Ala Gly Ala Val Ala Met Leu Ile Gly Pro Lys Ala Pro Leu Ala
65                  70                  75                  80  
Leu Glu Arg Gly Leu Arg Gly Thr His Met Glu Asn Val Tyr Asp Phe
                85                  90                  95      
Tyr Lys Pro Asn Leu Ala Ser Glu Tyr Pro Ile Val Asp Gly Lys Leu
            100                 105                 110         
Ser Ile Gln Cys Tyr Leu Arg Ala Leu Asp Arg Cys Tyr Thr Ser Tyr
        115                 120                 125             
Arg Lys Lys Ile Gln Asn Gln Trp Lys Gln Ala Gly Ser Asp Arg Pro
    130                 135                 140                 
Phe Thr Leu Asp Asp Leu Gln Tyr Met Ile Phe His Thr Pro Phe Cys
145                 150                 155                 160 
Lys Met Val Gln Lys Ser Leu Ala Arg Leu Met Phe Asn Asp Phe Leu
                165                 170                 175     
Ser Ala Ser Ser Asp Thr Gln Thr Ser Leu Tyr Lys Gly Leu Glu Ala
            180                 185                 190         
Phe Gly Gly Leu Lys Leu Glu Asp Thr Tyr Thr Asn Lys Asp Leu Asp
        195                 200                 205             
Lys Ala Leu Leu Lys Ala Ser Gln Asp Met Phe Asp Lys Lys Thr Lys
    210                 215                 220                 
Ala Ser Leu Tyr Leu Ser Thr His Asn Gly Asn Met Tyr Thr Ser Ser
225                 230                 235                 240 
Leu Tyr Gly Cys Leu Ala Ser Leu Leu Ser His His Ser Ala Gln Glu
                245                 250                 255     
Leu Ala Gly Ser Arg Ile Gly Ala Phe Ser Tyr Gly Ser Gly Leu Ala
            260                 265                 270         
Ala Ser Phe Phe Ser Phe Arg Val Ser Gln Asp Ala Ala Pro Gly Ser
        275                 280                 285             
Pro Leu Asp Lys Leu Val Ser Ser Thr Ser Asp Leu Pro Lys Arg Leu
    290                 295                 300                 
Ala Ser Arg Lys Cys Val Ser Pro Glu Glu Phe Thr Glu Ile Met Asn
305                 310                 315                 320 
Gln Arg Glu Gln Phe Tyr His Lys Val Asn Phe Ser Pro Pro Gly Asp
                325                 330                 335     
Thr Asn Ser Leu Phe Pro Gly Thr Trp Tyr Leu Glu Arg Val Asp Glu
            340                 345                 350         
Gln His Arg Arg Lys Tyr Ala Arg Arg Pro Val
        355                 360             


<210> 2044
<211> 185
<212> PRT
<213> Homo sapiens

<400> 2044
Met Ser Asn Gly Tyr Arg Thr Leu Ser Gln His Leu Asn Asp Leu Lys
 1               5                  10                  15      
Lys Glu Asn Phe Ser Leu Lys Leu Leu Ile Tyr Phe Leu Glu Glu Arg
            20                  25                  30          
Met Gln Gln Lys Tyr Glu Ala Ser Arg Glu Asp Ile Tyr Lys Arg Asn
        35                  40                  45              
Thr Glu Leu Lys Val Glu Val Glu Ser Leu Lys Arg Glu Leu Gln Asp
    50                  55                  60                  
Lys Lys Gln His Leu Asp Lys Thr Trp Ala Asp Val Glu Asn Leu Asn
65                  70                  75                  80  
Ser Gln Asn Glu Ala Glu Leu Arg Arg Gln Phe Glu Glu Arg Gln Gln
                85                  90                  95      
Glu Thr Glu His Val Tyr Glu Leu Leu Glu Asn Lys Ile Gln Leu Leu
            100                 105                 110         
Gln Glu Glu Ser Arg Leu Ala Lys Asn Glu Ala Ala Arg Met Ala Ala
        115                 120                 125             
Leu Val Glu Ala Glu Lys Glu Cys Asn Leu Glu Leu Ser Glu Lys Leu
    130                 135                 140                 
Lys Gly Val Thr Lys Asn Trp Glu Asp Val Pro Gly Asp Gln Val Lys
145                 150                 155                 160 
Pro Asp Gln Tyr Thr Glu Ala Leu Ala Gln Arg Asp Asn Pro Ser Thr
                165                 170                 175     
Asp Ser Leu Lys Asn Phe Arg Leu Phe
            180                 185 


<210> 2045
<211> 198
<212> PRT
<213> Homo sapiens

<400> 2045
Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu
 1               5                  10                  15      
His Ala Gln Ala Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro
            20                  25                  30          
Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln
        35                  40                  45              
Gly Lys Trp Tyr Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu
    50                  55                  60                  
Asp Lys Asp Pro Gln Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys Glu
65                  70                  75                  80  
Asp Lys Ser Tyr Asn Val Thr Ser Val Leu Phe Arg Lys Lys Lys Cys
                85                  90                  95      
Asp Tyr Trp Ile Arg Thr Phe Val Pro Gly Cys Gln Pro Gly Glu Phe
            100                 105                 110         
Thr Leu Gly Asn Ile Lys Ser Tyr Pro Gly Leu Thr Ser Tyr Leu Val
        115                 120                 125             
Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys
    130                 135                 140                 
Lys Val Ser Gln Asn Arg Glu Tyr Phe Lys Ile Thr Leu Tyr Gly Arg
145                 150                 155                 160 
Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser
                165                 170                 175     
Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile
            180                 185                 190         
Asp Gln Cys Ile Asp Gly
        195             


<210> 2046
<211> 1365
<212> PRT
<213> Homo sapiens

<400> 2046
Met Asp Pro Ser Gly Val Lys Val Leu Glu Thr Ala Glu Asp Ile Gln
 1               5                  10                  15      
Glu Arg Arg Gln Gln Val Leu Asp Arg Tyr His Arg Phe Lys Glu Leu
            20                  25                  30          
Ser Thr Leu Arg Arg Gln Lys Leu Glu Asp Ser Tyr Arg Phe Gln Phe
        35                  40                  45              
Phe Gln Arg Asp Ala Glu Glu Leu Glu Lys Trp Ile Gln Glu Lys Leu
    50                  55                  60                  
Gln Ile Ala Ser Asp Glu Asn Tyr Lys Asp Pro Thr Asn Leu Gln Gly
65                  70                  75                  80  
Lys Leu Gln Lys His Gln Ala Phe Glu Ala Glu Val Gln Ala Asn Ser
                85                  90                  95      
Gly Ala Ile Val Lys Leu Asp Glu Thr Gly Asn Leu Met Ile Ser Glu
            100                 105                 110         
Gly His Phe Ala Ser Glu Thr Ile Arg Thr Arg Leu Met Glu Leu His
        115                 120                 125             
Arg Gln Trp Glu Leu Leu Leu Glu Lys Met Arg Glu Lys Gly Ile Lys
    130                 135                 140                 
Leu Leu Gln Ala Gln Lys Leu Val Gln Tyr Leu Arg Glu Cys Glu Asp
145                 150                 155                 160 
Val Met Asp Trp Ile Asn Asp Lys Glu Ala Ile Val Thr Ser Glu Glu
                165                 170                 175     
Leu Gly Gln Asp Leu Glu His Val Glu Val Leu Gln Lys Lys Phe Glu
            180                 185                 190         
Glu Phe Gln Thr Asp Met Ala Ala His Glu Glu Arg Val Asn Glu Val
        195                 200                 205             
Asn Gln Phe Ala Ala Lys Leu Ile Gln Glu Gln His Pro Glu Glu Glu
    210                 215                 220                 
Leu Ile Lys Thr Lys Gln Asp Glu Val Asn Ala Ala Trp Gln Arg Leu
225                 230                 235                 240 
Lys Gly Leu Ala Leu Gln Arg Gln Gly Lys Leu Phe Gly Ala Ala Glu
                245                 250                 255     
Val Gln Arg Phe Asn Arg Asp Val Asp Glu Thr Ile Ser Trp Ile Lys
            260                 265                 270         
Glu Lys Glu Gln Leu Met Ala Ser Asp Asp Phe Gly Arg Asp Leu Ala
        275                 280                 285             
Ser Val Gln Ala Leu Leu Arg Lys His Glu Gly Leu Glu Arg Asp Leu
    290                 295                 300                 
Ala Ala Leu Glu Asp Lys Val Lys Ala Leu Cys Ala Glu Ala Asp Arg
305                 310                 315                 320 
Leu Gln Gln Ser His Pro Leu Ser Ala Thr Gln Ile Gln Val Lys Arg
                325                 330                 335     
Glu Glu Leu Ile Thr Asn Trp Glu Gln Ile Arg Thr Leu Ala Ala Glu
            340                 345                 350         
Arg His Ala Arg Leu Asn Asp Ser Tyr Arg Leu Gln Arg Phe Leu Ala
        355                 360                 365             
Asp Phe Arg Asp Leu Thr Ser Trp Val Thr Glu Met Lys Ala Leu Ile
    370                 375                 380                 
Asn Ala Asp Glu Leu Ala Ser Asp Val Ala Gly Ala Glu Ala Leu Leu
385                 390                 395                 400 
Asp Arg His Gln Glu His Lys Gly Glu Ile Asp Ala His Glu Asp Ser
                405                 410                 415     
Phe Lys Ser Ala Asp Glu Ser Gly Gln Ala Leu Leu Ala Ala Gly His
            420                 425                 430         
Tyr Ala Ser Asp Glu Val Arg Glu Lys Leu Thr Val Leu Ser Glu Glu
        435                 440                 445             
Arg Ala Ala Leu Leu Glu Leu Trp Glu Leu Arg Arg Gln Gln Tyr Glu
    450                 455                 460                 
Gln Cys Met Asp Leu Gln Leu Phe Tyr Arg Asp Thr Glu Gln Val Asp
465                 470                 475                 480 
Asn Trp Met Ser Lys Gln Glu Ala Phe Leu Leu Asn Glu Asp Leu Gly
                485                 490                 495     
Asp Ser Leu Asp Ser Val Glu Ala Leu Leu Lys Lys His Glu Asp Phe
            500                 505                 510         
Glu Lys Ser Leu Ser Ala Gln Glu Glu Lys Ile Thr Ala Leu Asp Glu
        515                 520                 525             
Phe Ala Thr Lys Leu Ile Gln Asn Asn His Tyr Ala Met Glu Asp Val
    530                 535                 540                 
Ala Thr Arg Arg Asp Ala Leu Leu Ser Arg Arg Asn Ala Leu His Glu
545                 550                 555                 560 
Arg Ala Met Arg Arg Arg Ala Gln Leu Ala Asp Ser Phe His Leu Gln
                565                 570                 575     
Gln Phe Phe Arg Asp Ser Asp Glu Leu Lys Ser Trp Val Asn Glu Lys
            580                 585                 590         
Met Lys Thr Ala Thr Asp Glu Ala Tyr Lys Asp Pro Ser Asn Leu Gln
        595                 600                 605             
Gly Lys Val Gln Lys His Gln Ala Phe Glu Ala Glu Leu Ser Ala Asn
    610                 615                 620                 
Gln Ser Arg Ile Asp Ala Leu Glu Lys Ala Gly Gln Lys Leu Ile Asp
625                 630                 635                 640 
Val Asn His Tyr Ala Lys Asp Glu Val Ala Ala Arg Met Asn Glu Val
                645                 650                 655     
Ile Ser Leu Trp Lys Lys Leu Leu Glu Ala Thr Glu Leu Lys Gly Ile
            660                 665                 670         
Lys Leu Arg Glu Ala Asn Gln Gln Gln Gln Phe Asn Arg Asn Val Glu
        675                 680                 685             
Asp Ile Glu Leu Trp Leu Tyr Glu Val Glu Gly His Leu Ala Ser Asp
    690                 695                 700                 
Asp Tyr Gly Lys Asp Leu Thr Asn Val Gln Asn Leu Gln Lys Lys His
705                 710                 715                 720 
Ala Leu Leu Glu Ala Asp Val Ala Ala His Gln Asp Arg Ile Asp Gly
                725                 730                 735     
Ile Thr Ile Gln Ala Arg Gln Phe Gln Asp Ala Gly His Phe Asp Ala
            740                 745                 750         
Glu Asn Ile Lys Lys Lys Gln Glu Ala Leu Val Ala Arg Tyr Glu Ala
        755                 760                 765             
Leu Lys Glu Pro Met Val Ala Arg Lys Gln Lys Leu Ala Asp Ser Leu
    770                 775                 780                 
Arg Leu Gln Gln Leu Phe Arg Asp Val Glu Asp Glu Glu Thr Trp Ile
785                 790                 795                 800 
Arg Glu Lys Glu Pro Ile Ala Ala Ser Thr Asn Arg Gly Lys Asp Leu
                805                 810                 815     
Ile Gly Val Gln Asn Leu Leu Lys Lys His Gln Ala Leu Gln Ala Glu
            820                 825                 830         
Ile Ala Gly His Glu Pro Arg Ile Lys Ala Val Thr Gln Lys Gly Asn
        835                 840                 845             
Ala Met Val Glu Glu Gly His Phe Ala Ala Glu Asp Val Lys Ala Lys
    850                 855                 860                 
Leu His Glu Leu Asn Gln Lys Trp Glu Ala Leu Lys Ala Lys Ala Ser
865                 870                 875                 880 
Gln Arg Arg Gln Asp Leu Glu Asp Ser Leu Gln Ala Gln Gln Tyr Phe
                885                 890                 895     
Ala Asp Ala Asn Glu Ala Glu Ser Trp Met Arg Glu Lys Glu Pro Ile
            900                 905                 910         
Val Gly Ser Thr Asp Tyr Gly Lys Asp Glu Asp Ser Ala Glu Ala Leu
        915                 920                 925             
Leu Lys Lys His Glu Ala Leu Met Ser Asp Leu Ser Ala Tyr Gly Ser
    930                 935                 940                 
Ser Ile Gln Ala Leu Arg Glu Gln Ala Gln Ser Cys Arg Gln Gln Val
945                 950                 955                 960 
Ala Pro Thr Asp Asp Glu Thr Gly Lys Glu Leu Val Leu Ala Leu Tyr
                965                 970                 975     
Asp Tyr Gln Glu Lys Ser Pro Arg Glu Val Thr Met Lys Lys Gly Asp
            980                 985                 990         
Ile Leu Thr Leu Leu Asn Ser Thr Asn Lys Asp Trp Trp Lys Val Glu
        995                 1000                1005            
Val Asn Asp Arg Gln Gly Phe Val Pro Ala Ala Tyr Val Lys Lys Leu
    1010                1015                1020                
Asp Pro Ala Gln Ser Ala Ser Arg Glu Asn Leu Leu Glu Glu Gln Gly
1025                1030                1035                1040
Ser Ile Ala Leu Arg Gln Glu Gln Ile Asp Asn Gln Thr Arg Ile Thr
                1045                1050                1055    
Lys Glu Ala Gly Ser Val Ser Leu Arg Met Lys Gln Val Glu Glu Leu
            1060                1065                1070        
Tyr His Ser Leu Leu Glu Leu Gly Glu Lys Arg Lys Gly Met Leu Glu
        1075                1080                1085            
Lys Ser Cys Lys Lys Phe Met Leu Phe Arg Glu Ala Asn Glu Leu Gln
    1090                1095                1100                
Gln Trp Ile Asn Glu Lys Glu Ala Ala Leu Thr Ser Glu Glu Val Gly
1105                1110                1115                1120
Ala Asp Leu Glu Gln Val Glu Val Leu Gln Lys Lys Phe Asp Asp Phe
                1125                1130                1135    
Gln Lys Asp Leu Lys Ala Asn Glu Ser Arg Leu Lys Asp Ile Asn Lys
            1140                1145                1150        
Val Ala Glu Asp Leu Glu Ser Glu Gly Leu Met Ala Glu Glu Val Gln
        1155                1160                1165            
Ala Val Gln Gln Gln Glu Val Tyr Gly Met Met Pro Arg Asp Glu Thr
    1170                1175                1180                
Asp Ser Lys Thr Ala Ser Pro Trp Lys Ser Ala Arg Leu Met Val His
1185                1190                1195                1200
Thr Val Ala Thr Phe Asn Ser Ile Lys Glu Leu Asn Glu Arg Trp Arg
                1205                1210                1215    
Ser Leu Gln Gln Leu Ala Glu Glu Arg Ser Gln Leu Leu Gly Ser Ala
            1220                1225                1230        
His Glu Val Gln Arg Phe His Arg Asp Ala Asp Glu Thr Lys Glu Trp
        1235                1240                1245            
Ile Glu Glu Lys Asn Gln Ala Leu Asn Thr Asp Asn Tyr Gly His Asp
    1250                1255                1260                
Leu Ala Ser Val Gln Ala Leu Gln Arg Lys His Glu Gly Phe Glu Arg
1265                1270                1275                1280
Asp Leu Ala Ala Leu Gly Asp Lys Val Asn Ser Leu Gly Glu Thr Ala
                1285                1290                1295    
Glu Arg Leu Ile Gln Ser His Pro Glu Ser Ala Glu Asp Leu Gln Glu
            1300                1305                1310        
Lys Cys Thr Glu Leu Asn Gln Ala Trp Ser Ser Leu Gly Lys Arg Ala
        1315                1320                1325            
Asp Gln Arg Lys Ala Lys Leu Gly Asp Ser His Asp Leu Gln Arg Phe
    1330                1335                1340                
Leu Ser Asp Phe Arg Gly Pro His Val Leu Asp Gln Trp Asn Thr Gly
1345                1350                1355                1360
Val Gly Val Leu Arg
                1365


<210> 2047
<211> 352
<212> PRT
<213> Homo sapiens

<400> 2047
Met Ala Pro Leu Gly Tyr Phe Leu Leu Leu Cys Ser Leu Lys Gln Ala
 1               5                  10                  15      
Leu Gly Ser Tyr Pro Ile Trp Trp Ser Leu Ala Val Gly Pro Gln Tyr
            20                  25                  30          
Ser Ser Leu Gly Ser Gln Pro Ile Leu Cys Ala Ser Ile Pro Gly Leu
        35                  40                  45              
Val Pro Lys Gln Leu Arg Phe Cys Arg Asn Tyr Val Glu Ile Met Pro
    50                  55                  60                  
Ser Val Ala Glu Gly Ile Lys Ile Gly Ile Gln Glu Cys Gln His Gln
65                  70                  75                  80  
Phe Arg Gly Arg Arg Trp Asn Cys Thr Thr Val His Asp Ser Leu Ala
                85                  90                  95      
Ile Phe Gly Pro Val Leu Asp Lys Ala Thr Arg Glu Ser Ala Phe Val
            100                 105                 110         
His Ala Ile Ala Ser Ala Gly Val Ala Phe Ala Val Thr Arg Ser Cys
        115                 120                 125             
Ala Glu Gly Thr Ala Ala Ile Cys Gly Cys Ser Ser Arg His Gln Gly
    130                 135                 140                 
Ser Pro Gly Lys Gly Trp Lys Trp Gly Gly Cys Ser Glu Asp Ile Glu
145                 150                 155                 160 
Phe Gly Gly Met Val Ser Arg Glu Phe Ala Asp Ala Arg Glu Asn Arg
                165                 170                 175     
Pro Asp Ala Arg Ser Ala Met Asn Arg His Asn Asn Glu Ala Gly Arg
            180                 185                 190         
Gln Ala Ile Ala Ser His Met His Leu Lys Cys Lys Cys His Gly Leu
        195                 200                 205             
Ser Gly Ser Cys Glu Val Lys Thr Cys Trp Trp Ser Gln Pro Asp Phe
    210                 215                 220                 
Arg Ala Ile Gly Asp Phe Leu Lys Asp Lys Tyr Asp Ser Ala Ser Glu
225                 230                 235                 240 
Met Val Val Glu Lys His Arg Glu Ser Arg Gly Trp Val Glu Thr Leu
                245                 250                 255     
Arg Pro Arg Tyr Thr Tyr Phe Lys Val Pro Thr Glu Arg Asp Leu Val
            260                 265                 270         
Tyr Tyr Glu Ala Ser Pro Asn Phe Cys Glu Pro Asn Pro Glu Thr Gly
        275                 280                 285             
Ser Phe Gly Thr Arg Asp Arg Thr Cys Asn Val Ser Ser His Gly Ile
    290                 295                 300                 
Asp Gly Cys Asp Leu Leu Cys Cys Gly Arg Gly His Asn Ala Arg Ala
305                 310                 315                 320 
Glu Arg Arg Arg Glu Lys Cys Arg Cys Val Phe His Trp Cys Cys Tyr
                325                 330                 335     
Val Ser Cys Gln Glu Cys Thr Arg Val Tyr Asp Val His Thr Cys Lys
            340                 345                 350         


<210> 2048
<211> 381
<212> PRT
<213> Homo sapiens

<400> 2048
Met Ser Gly Val Val Arg Thr Leu Ser Arg Cys Leu Leu Pro Ala Glu
 1               5                  10                  15      
Ala Gly Gly Ala Arg Glu Arg Arg Ala Gly Ser Gly Ala Arg Asp Ala
            20                  25                  30          
Glu Arg Glu Ala Arg Arg Arg Ser Arg Asp Ile Asp Ala Leu Leu Ala
        35                  40                  45              
Arg Glu Arg Arg Ala Val Arg Arg Leu Val Lys Ile Leu Leu Leu Gly
    50                  55                  60                  
Ala Gly Glu Ser Gly Lys Ser Thr Phe Leu Lys Gln Met Arg Ile Ile
65                  70                  75                  80  
His Gly Arg Glu Phe Asp Gln Lys Ala Leu Leu Glu Phe Arg Asp Thr
                85                  90                  95      
Ile Phe Asp Asn Ile Leu Lys Gly Ser Arg Val Leu Val Asp Ala Arg
            100                 105                 110         
Asp Lys Leu Gly Ile Pro Trp Gln Tyr Ser Glu Asn Glu Lys His Gly
        115                 120                 125             
Met Phe Leu Met Ala Phe Glu Asn Lys Ala Gly Leu Pro Val Glu Pro
    130                 135                 140                 
Ala Thr Phe Gln Leu Tyr Val Pro Ala Leu Ser Ala Leu Trp Arg Asp
145                 150                 155                 160 
Ser Gly Ile Arg Glu Ala Phe Ser Arg Arg Ser Glu Phe Gln Leu Gly
                165                 170                 175     
Glu Ser Val Lys Tyr Phe Leu Asp Asn Leu Asp Arg Ile Gly Gln Leu
            180                 185                 190         
Asn Tyr Phe Pro Ser Lys Gln Asp Ile Leu Leu Ala Arg Lys Ala Thr
        195                 200                 205             
Lys Gly Ile Val Glu His Asp Phe Val Ile Lys Lys Ile Pro Phe Lys
    210                 215                 220                 
Met Val Asp Val Gly Gly Gln Arg Ser Gln Arg Gln Lys Trp Phe Gln
225                 230                 235                 240 
Cys Phe Asp Gly Ile Thr Ser Ile Leu Phe Met Val Ser Ser Ser Glu
                245                 250                 255     
Tyr Asp Gln Val Leu Met Glu Asp Arg Arg Thr Asn Arg Leu Val Glu
            260                 265                 270         
Ser Met Asn Ile Phe Glu Thr Ile Val Asn Asn Lys Leu Phe Phe Asn
        275                 280                 285             
Val Ser Ile Ile Leu Phe Leu Asn Lys Met Asp Leu Leu Val Glu Lys
    290                 295                 300                 
Val Lys Thr Val Ser Ile Lys Lys His Phe Pro Asp Phe Arg Gly Asp
305                 310                 315                 320 
Pro His Arg Leu Glu Asp Val Gln Arg Tyr Leu Val Gln Cys Phe Asp
                325                 330                 335     
Arg Lys Arg Arg Asn Arg Ser Lys Pro Leu Phe His His Phe Thr Thr
            340                 345                 350         
Ala Ile Asp Thr Glu Asn Val Arg Phe Val Phe His Ala Val Lys Asp
        355                 360                 365             
Thr Ile Leu Gln Glu Asn Leu Lys Asp Ile Met Leu Gln
    370                 375                 380     


<210> 2049
<211> 625
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 365, 366, 367, 368, 369, 370, 371, 372, 373, 374, 375, 376,
377, 378, 379, 380, 381, 382, 383, 384, 385, 386, 387, 388,
389, 390, 391, 392, 393, 394, 395, 396, 397, 398, 399, 400,
401, 402, 403, 404, 405, 406, 407, 408, 409, 410, 411
<223> Xaa = Any Amino Acid

<221> VARIANT        
<222> 412, 413, 414, 415, 416, 417, 418, 419, 420, 421, 422, 423,
424, 425, 426, 427, 428, 429, 430, 431, 432, 433, 434, 435,
436, 437, 438, 439, 440, 441, 442, 443, 444, 445, 446, 447,
448, 449
<223> Xaa = Any Amino Acid

<400> 2049
Met Ser Tyr Ser Val Thr Leu Thr Gly Pro Gly Pro Trp Gly Phe Arg
 1               5                  10                  15      
Leu Gln Gly Gly Lys Asp Phe Asn Met Pro Leu Thr Ile Ser Arg Ile
            20                  25                  30          
Thr Pro Gly Ser Lys Ala Ala Gln Ser Gln Leu Ser Gln Gly Asp Leu
        35                  40                  45              
Val Val Ala Ile Asp Gly Val Asn Thr Asp Thr Met Thr His Leu Glu
    50                  55                  60                  
Ala Gln Asn Lys Ile Lys Ser Ala Ser Tyr Asn Leu Ser Leu Thr Leu
65                  70                  75                  80  
Gln Lys Ser Lys Arg Pro Ile Pro Ile Ser Thr Thr Ala Pro Pro Val
                85                  90                  95      
Gln Thr Pro Leu Pro Val Ile Pro His Gln Lys Val Val Val Asn Ser
            100                 105                 110         
Pro Ala Asn Ala Asp Tyr Gln Glu Arg Phe Asn Pro Ser Ala Leu Lys
        115                 120                 125             
Asp Ser Ala Leu Ser Thr His Lys Pro Ile Glu Val Lys Gly Leu Gly
    130                 135                 140                 
Gly Lys Ala Thr Ile Ile His Ala Gln Tyr Asn Thr Pro Ile Ser Met
145                 150                 155                 160 
Tyr Ser Gln Asp Ala Ile Met Asp Ala Ile Ala Gly Gln Ala Gln Ala
                165                 170                 175     
Gln Gly Ser Asp Phe Ser Gly Ser Leu Pro Ile Lys Asp Leu Ala Val
            180                 185                 190         
Asp Ser Ala Ser Pro Val Tyr Gln Ala Val Ile Lys Ser Gln Asn Lys
        195                 200                 205             
Pro Glu Asp Glu Ala Asp Glu Trp Ala Arg Arg Ser Ser Asn Leu Gln
    210                 215                 220                 
Ser Arg Ser Phe Arg Ile Leu Ala Gln Met Thr Gly Thr Glu Phe Met
225                 230                 235                 240 
Gln Asp Pro Asp Glu Glu Ala Leu Arg Arg Ser Arg Pro Gln Ala Ser
                245                 250                 255     
Ser Tyr Ser Pro Ala Val Ala Ala Ser Ser Ala Pro Ala Thr His Thr
            260                 265                 270         
Ser Tyr Ser Glu Gly Pro Ala Ala Pro Ala Pro Lys Pro Arg Val Val
        275                 280                 285             
Thr Thr Ala Ser Ile Arg Pro Ser Val Tyr Gln Pro Val Pro Ala Ser
    290                 295                 300                 
Thr Tyr Ser Pro Ser Pro Gly Ala Asn Tyr Ser Pro Thr Pro Tyr Thr
305                 310                 315                 320 
Pro Ser Pro Ala Pro Ala Tyr Thr Pro Pro Leu Pro Leu Pro Thr Pro
                325                 330                 335     
Pro His Leu Ser Pro Pro Thr Leu His Pro Gln His Gln Pro Ile Pro
            340                 345                 350         
Arg Asp Leu Pro Pro Thr Ile Thr Leu His Pro Pro Xaa Xaa Xaa Xaa
        355                 360                 365             
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    370                 375                 380                 
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
385                 390                 395                 400 
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
                405                 410                 415     
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            420                 425                 430         
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
        435                 440                 445             
Xaa Gly Pro Phe Leu Val Ala Met Gly Arg Ser Trp His Pro Glu Glu
    450                 455                 460                 
Phe Thr Cys Ala Tyr Cys Lys Thr Ser Leu Ala Asp Val Cys Phe Val
465                 470                 475                 480 
Glu Glu Gln Asn Asn Val Tyr Cys Glu Arg Cys Tyr Glu Gln Phe Phe
                485                 490                 495     
Ala Pro Leu Cys Ala Lys Cys Asn Thr Lys Ile Met Gly Gly Ser Asn
            500                 505                 510         
Ala Cys Leu Glu Thr Asp Met Ala His His Leu Leu Arg Leu Cys Gly
        515                 520                 525             
Leu Gln Glu Ala Phe Trp Glu Gln Pro Leu Pro His Gly Arg Arg Gly
    530                 535                 540                 
Ala Leu Leu Arg Glu Arg Leu His Gln Ser Val Gln His Gln Val Pro
545                 550                 555                 560 
Trp Leu Arg Phe Pro Arg Gly Gly Trp Arg Gln Val Tyr Arg Ser Pro
                565                 570                 575     
Gly Pro His Leu Ala Arg His Leu Leu His Leu Arg Ser Leu Pro Cys
            580                 585                 590         
Glu Ser Gly Gly Ala Ala Val Leu Leu Gln Glu Gly Gln Thr Pro Val
        595                 600                 605             
Gln Glu Ala Arg Thr His His Gln Leu Val Gly Gly Gln Gly Arg Leu
    610                 615                 620                 
Cys
625 


<210> 2050
<211> 735
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 475, 476, 477, 478, 479, 480, 481, 482, 483, 484, 485, 486,
487, 488, 489, 490, 491, 492, 493, 494, 495, 496, 497, 498,
499, 500, 501, 502, 503, 504, 505, 506, 507, 508, 509, 510,
511, 512, 513, 514, 515, 516, 517, 518, 519, 520, 521
<223> Xaa = Any Amino Acid

<221> VARIANT        
<222> 522, 523, 524, 525, 526, 527, 528, 529, 530, 531, 532, 533,
534, 535, 536, 537, 538, 539, 540, 541, 542, 543, 544, 545,
546, 547, 548, 549, 550, 551, 552, 553, 554, 555, 556, 557,
558, 559
<223> Xaa = Any Amino Acid

<400> 2050
Met Ser Tyr Ser Val Thr Leu Thr Gly Pro Gly Pro Trp Gly Phe Arg
 1               5                  10                  15      
Leu Gln Gly Gly Lys Asp Phe Asn Met Pro Leu Thr Ile Ser Arg Ile
            20                  25                  30          
Thr Pro Gly Ser Lys Ala Ala Gln Ser Gln Leu Ser Gln Gly Asp Leu
        35                  40                  45              
Val Val Ala Ile Asp Gly Val Asn Thr Asp Thr Met Thr His Leu Glu
    50                  55                  60                  
Ala Gln Asn Lys Ile Lys Ser Ala Ser Tyr Asn Leu Ser Leu Thr Leu
65                  70                  75                  80  
Gln Lys Ser Lys Arg Pro Ile Pro Ile Ser Thr Thr Ala Pro Pro Val
                85                  90                  95      
Gln Thr Pro Leu Pro Val Ile Pro His Gln Lys Asp Pro Ala Leu Asp
            100                 105                 110         
Thr Asn Gly Ser Leu Val Ala Pro Ser Pro Ser Pro Glu Ala Arg Ala
        115                 120                 125             
Ser Pro Gly Thr Pro Gly Thr Pro Glu Leu Arg Pro Thr Phe Ser Pro
    130                 135                 140                 
Ala Phe Ser Arg Pro Ser Ala Phe Ser Ser Leu Ala Glu Ala Ser Asp
145                 150                 155                 160 
Pro Gly Pro Pro Arg Ala Ser Leu Arg Ala Lys Thr Ser Pro Glu Gly
                165                 170                 175     
Ala Arg Asp Leu Leu Gly Pro Lys Ala Leu Pro Gly Ser Ser Gln Pro
            180                 185                 190         
Arg Gln Tyr Asn Asn Pro Ile Gly Leu Tyr Ser Ala Glu Thr Leu Arg
        195                 200                 205             
Glu Met Ala Gln Met Tyr Gln Met Ser Leu Arg Gly Lys Ala Ser Gly
    210                 215                 220                 
Val Gly Leu Pro Gly Gly Ser Leu Pro Ile Lys Asp Leu Ala Val Asp
225                 230                 235                 240 
Ser Ala Ser Pro Val Tyr Gln Ala Val Ile Lys Ser Gln Asn Lys Pro
                245                 250                 255     
Glu Asp Glu Ala Asp Glu Trp Ala Arg Arg Ser Ser Asn Leu Gln Ser
            260                 265                 270         
Arg Ser Phe Arg Ile Leu Ala Gln Met Thr Gly Thr Glu Phe Met Gln
        275                 280                 285             
Asp Pro Asp Glu Glu Ala Leu Arg Arg Ser Ser Thr Pro Ile Glu His
    290                 295                 300                 
Ala Pro Val Cys Thr Ser Gln Ala Thr Thr Pro Leu Leu Pro Ala Ser
305                 310                 315                 320 
Ala Gln Pro Pro Ala Ala Ala Ser Pro Ser Ala Ala Ser Pro Pro Leu
                325                 330                 335     
Ala Thr Ala Ala Ala His Thr Ala Ile Ala Ser Ala Ser Thr Thr Ala
            340                 345                 350         
Pro Ala Ser Ser Pro Ala Asp Ser Pro Arg Pro Gln Ala Ser Ser Tyr
        355                 360                 365             
Ser Pro Ala Val Ala Ala Ser Ser Ala Pro Ala Thr His Thr Ser Tyr
    370                 375                 380                 
Ser Glu Gly Pro Ala Ala Pro Ala Pro Lys Pro Arg Val Val Thr Thr
385                 390                 395                 400 
Ala Ser Ile Arg Pro Ser Val Tyr Gln Pro Val Pro Ala Ser Thr Tyr
                405                 410                 415     
Ser Pro Ser Pro Gly Ala Asn Tyr Ser Pro Thr Pro Tyr Thr Pro Ser
            420                 425                 430         
Pro Ala Pro Ala Tyr Thr Pro Pro Leu Pro Leu Pro Thr Pro Pro His
        435                 440                 445             
Leu Ser Pro Pro Thr Leu His Pro Gln His Gln Pro Ile Pro Arg Asp
    450                 455                 460                 
Leu Pro Pro Thr Ile Thr Leu His Pro Pro Xaa Xaa Xaa Xaa Xaa Xaa
465                 470                 475                 480 
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
                485                 490                 495     
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            500                 505                 510         
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
        515                 520                 525             
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    530                 535                 540                 
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly
545                 550                 555                 560 
Pro Phe Leu Val Ala Met Gly Arg Ser Trp His Pro Glu Glu Phe Thr
                565                 570                 575     
Cys Ala Tyr Cys Lys Thr Ser Leu Ala Asp Val Cys Phe Val Glu Glu
            580                 585                 590         
Gln Asn Asn Val Tyr Cys Glu Arg Cys Tyr Glu Gln Phe Phe Ala Pro
        595                 600                 605             
Leu Cys Ala Lys Cys Asn Thr Lys Ile Met Gly Gly Ser Asn Ala Cys
    610                 615                 620                 
Leu Glu Thr Asp Met Ala His His Leu Leu Arg Leu Cys Gly Leu Gln
625                 630                 635                 640 
Glu Ala Phe Trp Glu Gln Pro Leu Pro His Gly Arg Arg Gly Ala Leu
                645                 650                 655     
Leu Arg Glu Arg Leu His Gln Ser Val Gln His Gln Val Pro Trp Leu
            660                 665                 670         
Arg Phe Pro Arg Gly Gly Trp Arg Gln Val Tyr Arg Ser Pro Gly Pro
        675                 680                 685             
His Leu Ala Arg His Leu Leu His Leu Arg Ser Leu Pro Cys Glu Ser
    690                 695                 700                 
Gly Gly Ala Ala Val Leu Leu Gln Glu Gly Gln Thr Pro Val Gln Glu
705                 710                 715                 720 
Ala Arg Thr His His Gln Leu Val Gly Gly Gln Gly Arg Leu Cys
                725                 730                 735 


<210> 2051
<211> 1275
<212> PRT
<213> Homo sapiens

<400> 2051
Met Val Gln Gly Pro Val Gln Thr Pro Ala Leu Thr Ile His Arg Arg
 1               5                  10                  15      
Lys Arg Arg Arg Ser Cys Pro Pro Asn Arg Ala Ser Tyr Leu Pro Lys
            20                  25                  30          
Ala Glu Ser Leu Ala Ser Leu Gly Ser His Leu Pro Ala Leu Leu Ser
        35                  40                  45              
Arg Ala Arg Val Pro Arg Pro Pro Ala Gly Arg Arg Glu Arg Glu Arg
    50                  55                  60                  
Arg Arg Arg Pro Val Ala Lys Ala Pro Ala Arg Leu Arg Gly Glu Tyr
65                  70                  75                  80  
Glu Thr Gly Val Lys Met Thr Ser Arg Phe Gly Lys Thr Tyr Ser Arg
                85                  90                  95      
Lys Gly Gly Asn Gly Ser Ser Lys Phe Asp Glu Val Phe Ser Asn Lys
            100                 105                 110         
Arg Thr Thr Leu Ser Thr Lys Trp Gly Glu Thr Thr Phe Met Ala Lys
        115                 120                 125             
Leu Gly Gln Lys Arg Pro Asn Phe Lys Pro Asp Ile Gln Glu Ile Pro
    130                 135                 140                 
Lys Lys Pro Lys Val Glu Glu Glu Ser Thr Gly Asp Pro Phe Gly Phe
145                 150                 155                 160 
Asp Ser Asp Asp Glu Ser Leu Pro Val Ser Ser Lys Asn Leu Ala Gln
                165                 170                 175     
Val Lys Cys Ser Ser Tyr Ser Glu Ser Ser Glu Ala Ala Gln Leu Glu
            180                 185                 190         
Glu Val Thr Ser Val Leu Glu Ala Asn Ser Lys Ile Ser His Val Val
        195                 200                 205             
Val Glu Asp Thr Val Val Ser Asp Lys Cys Phe Pro Leu Glu Asp Thr
    210                 215                 220                 
Leu Leu Gly Lys Glu Lys Ser Thr Asn Arg Ile Val Glu Asp Asp Ala
225                 230                 235                 240 
Ser Ile Ser Ser Cys Asn Lys Leu Ile Thr Ser Asp Lys Val Glu Asn
                245                 250                 255     
Phe His Glu Glu His Glu Lys Asn Ser His His Ile His Lys Asn Ala
            260                 265                 270         
Asp Asp Ser Thr Lys Lys Pro Asn Ala Glu Thr Thr Val Ala Ser Glu
        275                 280                 285             
Ile Lys Glu Thr Asn Asp Thr Trp Asn Ser Gln Phe Gly Lys Arg Pro
    290                 295                 300                 
Glu Ser Pro Ser Glu Ile Ser Pro Ile Lys Gly Ser Val Arg Thr Gly
305                 310                 315                 320 
Leu Phe Glu Trp Asp Asn Asp Phe Glu Asp Ile Arg Ser Glu Asp Cys
                325                 330                 335     
Ile Leu Ser Leu Asp Ser Asp Pro Leu Leu Glu Met Lys Asp Asp Asp
            340                 345                 350         
Phe Lys Asn Arg Leu Glu Asn Leu Asn Glu Ala Ile Glu Glu Asp Ile
        355                 360                 365             
Val Gln Ser Val Leu Arg Pro Thr Asn Cys Arg Thr Tyr Cys Arg Ala
    370                 375                 380                 
Asn Lys Thr Lys Ser Ser Gln Gly Ala Ser Asn Phe Asp Lys Leu Met
385                 390                 395                 400 
Asp Gly Thr Ser Gln Ala Leu Ala Lys Ala Asn Ser Glu Ser Ser Lys
                405                 410                 415     
Asp Gly Leu Asn Gln Ala Lys Lys Gly Gly Val Ser Cys Gly Thr Ser
            420                 425                 430         
Phe Arg Gly Thr Val Gly Arg Thr Arg Asp Tyr Thr Val Leu His Pro
        435                 440                 445             
Ser Cys Leu Ser Val Cys Asn Val Thr Ile Gln Asp Thr Met Glu Arg
    450                 455                 460                 
Ser Met Asp Glu Phe Thr Ala Ser Thr Pro Ala Asp Leu Gly Glu Ala
465                 470                 475                 480 
Gly Arg Leu Arg Lys Lys Ala Asp Ile Ala Thr Ser Lys Thr Thr Thr
                485                 490                 495     
Arg Phe Arg Pro Ser Asn Thr Lys Ser Lys Lys Asp Val Lys Leu Glu
            500                 505                 510         
Phe Phe Gly Phe Glu Asp His Glu Thr Gly Gly Asp Glu Gly Gly Ser
        515                 520                 525             
Gly Ser Ser Asn Tyr Lys Ile Lys Tyr Phe Gly Phe Asp Asp Leu Ser
    530                 535                 540                 
Glu Ser Glu Asp Asp Glu Asp Asp Asp Cys Gln Val Glu Arg Lys Thr
545                 550                 555                 560 
Ser Lys Lys Arg Thr Lys Thr Ala Pro Ser Pro Ser Leu Gln Pro Pro
                565                 570                 575     
Pro Glu Ser Asn Asp Asn Ser Gln Asp Ser Gln Ser Gly Thr Asn Asn
            580                 585                 590         
Ala Glu Asn Leu Asp Phe Thr Glu Asp Leu Pro Gly Val Pro Glu Ser
        595                 600                 605             
Val Lys Lys Pro Ile Asn Lys Gln Gly Asp Lys Ser Lys Glu Asn Thr
    610                 615                 620                 
Arg Lys Ile Phe Ser Gly Pro Lys Arg Ser Pro Thr Lys Ala Val Tyr
625                 630                 635                 640 
Asn Ala Arg His Trp Asn His Pro Asp Ser Glu Glu Leu Pro Gly Pro
                645                 650                 655     
Pro Val Val Lys Pro Gln Ser Val Thr Val Arg Leu Ser Ser Lys Glu
            660                 665                 670         
Pro Asn Gln Lys Asp Asp Gly Val Phe Lys Ala Pro Ala Pro Pro Ser
        675                 680                 685             
Lys Val Ile Lys Thr Val Thr Ile Pro Thr Gln Pro Tyr Gln Asp Ile
    690                 695                 700                 
Val Thr Ala Leu Lys Cys Arg Arg Glu Asp Lys Glu Leu Tyr Thr Val
705                 710                 715                 720 
Val Gln His Val Lys His Phe Asn Asp Val Val Glu Phe Gly Glu Asn
                725                 730                 735     
Gln Glu Phe Thr Asp Asp Ile Glu Tyr Leu Leu Ser Gly Leu Lys Ser
            740                 745                 750         
Thr Gln Pro Leu Asn Thr Arg Cys Leu Ser Val Ile Ser Leu Ala Thr
        755                 760                 765             
Lys Cys Ala Met Pro Ser Phe Arg Met His Leu Arg Ala His Gly Met
    770                 775                 780                 
Val Ala Met Val Phe Lys Thr Leu Asp Asp Ser Gln His His Gln Asn
785                 790                 795                 800 
Leu Ser Leu Cys Thr Ala Ala Leu Met Tyr Ile Leu Ser Arg Asp Arg
                805                 810                 815     
Leu Asn Met Asp Leu Asp Arg Ala Ser Leu Asp Leu Met Ile Arg Leu
            820                 825                 830         
Leu Glu Leu Glu Gln Asp Ala Ser Ser Ala Lys Leu Leu Asn Glu Lys
        835                 840                 845             
Asp Met Asn Lys Ile Lys Glu Lys Ile Arg Arg Leu Cys Glu Thr Val
    850                 855                 860                 
His Asn Lys His Leu Asp Leu Glu Asn Ile Thr Thr Gly His Leu Ala
865                 870                 875                 880 
Met Glu Thr Leu Leu Ser Leu Thr Ser Lys Arg Ala Gly Asp Trp Phe
                885                 890                 895     
Lys Glu Glu Leu Arg Leu Leu Gly Gly Leu Asp His Ile Val Asp Lys
            900                 905                 910         
Val Lys Glu Cys Val Asp His Leu Ser Arg Asp Glu Asp Glu Glu Lys
        915                 920                 925             
Leu Val Ala Ser Leu Trp Gly Ala Glu Arg Cys Leu Arg Val Leu Glu
    930                 935                 940                 
Ser Val Thr Val His Asn Pro Glu Asn Gln Ser Tyr Leu Ile Ala Tyr
945                 950                 955                 960 
Lys Asp Ser Gln Leu Ile Val Ser Ser Ala Lys Ala Leu Gln His Cys
                965                 970                 975     
Glu Glu Leu Ile Gln Gln Tyr Asn Arg Ala Glu Asp Ser Ile Cys Leu
            980                 985                 990         
Ala Asp Ser Lys Pro Leu Pro His Gln Asn Val Thr Asn His Val Gly
        995                 1000                1005            
Lys Ala Val Glu Asp Cys Met Arg Ala Ile Ile Gly Val Leu Leu Asn
    1010                1015                1020                
Leu Thr Asn Asp Asn Glu Trp Gly Ser Thr Lys Thr Gly Glu Gln Asp
1025                1030                1035                1040
Gly Leu Ile Gly Thr Ala Leu Asn Cys Val Leu Gln Val Pro Lys Tyr
                1045                1050                1055    
Leu Pro Gln Glu Gln Arg Phe Asp Ile Arg Val Leu Gly Leu Gly Leu
            1060                1065                1070        
Leu Ile Asn Leu Val Glu Tyr Ser Ala Arg Asn Arg His Cys Leu Val
        1075                1080                1085            
Asn Met Glu Thr Ser Cys Ser Phe Asp Ser Ser Ile Cys Ser Gly Glu
    1090                1095                1100                
Gly Asp Asp Ser Leu Arg Ile Gly Gly Gln Val His Ala Val Gln Ala
1105                1110                1115                1120
Leu Val Gln Leu Phe Leu Glu Arg Glu Arg Ala Ala Gln Leu Ala Glu
                1125                1130                1135    
Ser Lys Thr Asp Glu Leu Ile Lys Asp Ala Pro Thr Thr Gln His Asp
            1140                1145                1150        
Lys Ser Gly Glu Trp Gln Glu Thr Ser Gly Glu Ile Gln Trp Val Ser
        1155                1160                1165            
Thr Glu Lys Thr Asp Gly Thr Glu Glu Lys His Lys Lys Glu Glu Glu
    1170                1175                1180                
Asp Glu Glu Leu Asp Leu Asn Lys Ala Leu Gln His Ala Gly Lys His
1185                1190                1195                1200
Met Glu Asp Cys Ile Val Ala Ser Tyr Thr Ala Leu Leu Leu Gly Cys
                1205                1210                1215    
Leu Cys Gln Glu Ser Pro Ile Asn Val Thr Thr Val Arg Glu Tyr Leu
            1220                1225                1230        
Pro Glu Gly Asp Phe Ser Ile Met Thr Glu Met Leu Lys Lys Phe Leu
        1235                1240                1245            
Ser Phe Met Asn Leu Thr Cys Ala Val Gly Thr Thr Gly Gln Lys Ser
    1250                1255                1260                
Ile Ser Arg Val Ile Glu Tyr Leu Glu His Cys
1265                1270                1275


<210> 2052
<211> 188
<212> PRT
<213> Homo sapiens

<400> 2052
Met Tyr Ile Ala Leu Thr Gly Leu Gln His Ala Gly Arg Ile Leu Thr
 1               5                  10                  15      
Thr Arg Ile His Glu Leu Lys Gln Ala Lys Val Ser Thr Val Met Asp
            20                  25                  30          
Thr Val Gly Arg Arg Leu Arg Asp Ser Leu Gly Arg Thr Val Asp Leu
        35                  40                  45              
Gly Leu Thr Gly Asn His Gly Val Val His Pro Ser Leu Ala Asp Ser
    50                  55                  60                  
Ala Asn Lys Phe Glu Glu Asn Thr Tyr Cys Phe Gly Arg Thr Val Glu
65                  70                  75                  80  
Thr Leu Leu Leu Arg Phe Gly Lys Thr Ile Met Glu Glu Gln Leu Val
                85                  90                  95      
Leu Lys Arg Val Ala Asn Ile Leu Ile Asn Leu Tyr Gly Met Thr Ala
            100                 105                 110         
Val Leu Ser Arg Ala Ser Arg Ser Ile Arg Ile Gly Leu Arg Asn His
        115                 120                 125             
Asp His Glu Val Leu Leu Ala Asn Thr Phe Cys Val Glu Ala Tyr Leu
    130                 135                 140                 
Gln Asn Leu Phe Ser Leu Ser Gln Leu Asp Lys Tyr Ala Pro Glu Asn
145                 150                 155                 160 
Leu Asp Glu Gln Ile Lys Lys Val Ser Gln Gln Ile Leu Glu Lys Arg
                165                 170                 175     
Ala Tyr Ile Cys Ala His Pro Leu Asp Arg Thr Cys
            180                 185             


<210> 2053
<211> 621
<212> PRT
<213> Homo sapiens

<400> 2053
Met Ser Gly Cys Gly Leu Phe Leu Arg Thr Thr Ala Ala Ala Arg Ala
 1               5                  10                  15      
Cys Arg Gly Leu Val Val Ser Thr Ala Asn Arg Arg Leu Leu Arg Thr
            20                  25                  30          
Ser Pro Pro Val Arg Ala Phe Ala Lys Glu Leu Phe Leu Gly Lys Ile
        35                  40                  45              
Lys Lys Lys Glu Val Phe Pro Phe Pro Glu Val Ser Gln Asp Glu Leu
    50                  55                  60                  
Asn Glu Ile Asn Gln Phe Leu Gly Pro Val Glu Lys Phe Phe Thr Glu
65                  70                  75                  80  
Glu Val Asp Ser Arg Lys Ile Asp Gln Glu Gly Lys Ile Pro Asp Glu
                85                  90                  95      
Thr Leu Glu Lys Leu Lys Ser Leu Gly Leu Phe Gly Leu Gln Val Pro
            100                 105                 110         
Glu Glu Tyr Gly Gly Leu Gly Phe Ser Asn Thr Met Tyr Ser Arg Leu
        115                 120                 125             
Gly Glu Ile Ile Ser Met Asp Gly Ser Ile Thr Val Thr Leu Ala Ala
    130                 135                 140                 
His Gln Ala Ile Gly Leu Lys Gly Ile Ile Leu Ala Gly Thr Glu Glu
145                 150                 155                 160 
Gln Lys Ala Lys Tyr Leu Pro Lys Leu Ala Ser Gly Glu His Ile Ala
                165                 170                 175     
Ala Phe Cys Leu Thr Glu Pro Ala Ser Gly Ser Asp Ala Ala Ser Ile
            180                 185                 190         
Arg Ser Arg Ala Thr Leu Ser Glu Asp Lys Lys His Tyr Ile Leu Asn
        195                 200                 205             
Gly Ser Lys Val Trp Ile Thr Asn Gly Gly Leu Ala Asn Ile Phe Thr
    210                 215                 220                 
Val Phe Ala Lys Thr Glu Val Val Asp Ser Asp Gly Ser Val Lys Asp
225                 230                 235                 240 
Lys Ile Thr Ala Phe Ile Val Glu Arg Asp Phe Gly Gly Val Thr Asn
                245                 250                 255     
Gly Lys Pro Glu Asp Lys Leu Gly Ile Arg Gly Ser Asn Thr Cys Glu
            260                 265                 270         
Val His Phe Glu Asn Thr Lys Ile Pro Val Glu Asn Ile Leu Gly Glu
        275                 280                 285             
Val Gly Asp Gly Phe Lys Val Ala Met Asn Ile Leu Asn Ser Gly Arg
    290                 295                 300                 
Phe Ser Met Gly Ser Val Val Ala Gly Leu Leu Lys Arg Leu Ile Glu
305                 310                 315                 320 
Met Thr Ala Glu Tyr Ala Cys Thr Arg Lys Gln Phe Asn Lys Arg Leu
                325                 330                 335     
Ser Glu Phe Gly Leu Ile Gln Glu Lys Phe Ala Leu Met Ala Gln Lys
            340                 345                 350         
Ala Tyr Val Met Glu Ser Met Thr Tyr Leu Thr Ala Gly Met Leu Asp
        355                 360                 365             
Gln Pro Gly Phe Pro Asp Cys Ser Ile Glu Ala Ala Met Val Lys Val
    370                 375                 380                 
Phe Ser Ser Glu Ala Ala Trp Gln Cys Val Ser Glu Ala Leu Gln Ile
385                 390                 395                 400 
Leu Gly Gly Leu Gly Tyr Thr Arg Asp Tyr Pro Tyr Glu Arg Ile Leu
                405                 410                 415     
Arg Asp Thr Arg Ile Leu Leu Ile Phe Glu Gly Thr Asn Glu Ile Leu
            420                 425                 430         
Arg Met Tyr Ile Ala Leu Thr Gly Leu Gln His Ala Gly Arg Ile Leu
        435                 440                 445             
Thr Thr Arg Ile His Glu Leu Lys Gln Ala Lys Val Ser Thr Val Met
    450                 455                 460                 
Asp Thr Val Gly Arg Arg Leu Arg Asp Ser Leu Gly Arg Thr Val Asp
465                 470                 475                 480 
Leu Gly Leu Thr Gly Asn His Gly Val Val His Pro Ser Leu Ala Asp
                485                 490                 495     
Ser Ala Asn Lys Phe Glu Glu Asn Thr Tyr Cys Phe Gly Arg Thr Val
            500                 505                 510         
Glu Thr Leu Leu Leu Arg Phe Gly Lys Thr Ile Met Glu Glu Gln Leu
        515                 520                 525             
Val Leu Lys Arg Val Ala Asn Ile Leu Ile Asn Leu Tyr Gly Met Thr
    530                 535                 540                 
Ala Val Leu Ser Arg Ala Ser Arg Ser Ile Arg Ile Gly Leu Arg Asn
545                 550                 555                 560 
His Asp His Glu Val Leu Leu Ala Asn Thr Phe Cys Val Glu Ala Tyr
                565                 570                 575     
Leu Gln Asn Leu Phe Ser Leu Ser Gln Leu Asp Lys Tyr Ala Pro Glu
            580                 585                 590         
Asn Leu Asp Glu Gln Ile Lys Lys Val Ser Gln Gln Ile Leu Glu Lys
        595                 600                 605             
Arg Ala Tyr Ile Cys Ala His Pro Leu Asp Arg Thr Cys
    610                 615                 620     


<210> 2054
<211> 1454
<212> PRT
<213> Homo sapiens

<400> 2054
Met Phe Ala Phe Asp Ala Val Phe Pro Gln Asp Ser Glu Gln Ala Glu
 1               5                  10                  15      
Val Cys Ser Gly Thr Val Ala Asp Val Leu Gln Ser Val Val Ser Gly
            20                  25                  30          
Ala Asp Gly Cys Ile Phe Ser Phe Gly His Met Ser Leu Gly Lys Ser
        35                  40                  45              
Tyr Thr Met Ile Gly Lys Asp Ser Ser Pro Gln Ser Leu Gly Ile Val
    50                  55                  60                  
Pro Cys Ala Ile Ser Trp Leu Phe Arg Leu Ile Glu Glu Arg Arg Glu
65                  70                  75                  80  
Arg Thr Gly Thr Arg Phe Ser Val Arg Val Ser Ala Val Glu Val Cys
                85                  90                  95      
Gly Arg Asp Gln Ser Leu Arg Asp Leu Leu Ala Glu Val Ala Pro Gly
            100                 105                 110         
Ser Leu Gln Asp Thr Gln Ser Pro Gly Val Tyr Leu Arg Glu Asp Pro
        115                 120                 125             
Val Cys Gly Ala Gln Leu Gln Asn Gln Ser Glu Leu Arg Ala Pro Thr
    130                 135                 140                 
Ala Glu Lys Ala Ala Phe Tyr Leu Asp Ala Ala Leu Ala Ala Arg Ser
145                 150                 155                 160 
Thr Ser Arg Ala Gly Cys Gly Glu Asp Ala Arg Arg Ser Ser His Met
                165                 170                 175     
Leu Phe Thr Leu His Val Tyr Gln Tyr Arg Met Glu Lys Cys Gly Arg
            180                 185                 190         
Gly Gly Met Ser Gly Gly Arg Ser Arg Leu His Leu Ile Asp Leu Gly
        195                 200                 205             
Ser Cys Glu Ala Ala Ala Gly Arg Ala Gly Glu Ala Ala Gly Gly Pro
    210                 215                 220                 
Leu Cys Leu Ser Leu Ser Ala Leu Gly Ser Val Ile Leu Ala Leu Val
225                 230                 235                 240 
Asn Gly Ala Lys His Val Pro Tyr Arg Asp His Arg Leu Thr Met Leu
                245                 250                 255     
Leu Arg Glu Ser Leu Ala Thr Ala Gly Cys Arg Thr Thr Met Ile Ala
            260                 265                 270         
His Val Ser Asp Ala Pro Ala Gln His Ala Glu Thr Leu Ser Thr Val
        275                 280                 285             
Gln Leu Ala Ala Arg Ile His Arg Leu Arg Arg Lys Lys Ala Lys Tyr
    290                 295                 300                 
Ala Ser Ser Ser Ser Gly Gly Glu Ser Ser Cys Glu Glu Gly Arg Ala
305                 310                 315                 320 
Arg Arg Pro Pro His Leu Arg Pro Phe His Pro Arg Thr Val Ala Leu
                325                 330                 335     
Asp Pro Asp Arg Thr Pro Pro Cys Leu Pro Gly Asp Pro Asp Tyr Ser
            340                 345                 350         
Ser Ser Ser Glu Gln Ser Cys Asp Thr Val Ile Tyr Val Gly Pro Gly
        355                 360                 365             
Gly Ala Ala Leu Ser Asp Arg Glu Leu Thr Asp Asn Glu Gly Pro Pro
    370                 375                 380                 
Asp Phe Val Pro Ile Ile Pro Ala Leu Ser Arg His Arg Pro Ser Lys
385                 390                 395                 400 
Gly Pro Arg Asp Ala Asp His Phe Arg Cys Ser Thr Phe Ala Glu Leu
                405                 410                 415     
Gln Glu Arg Leu Glu Cys Met Asp Gly Asn Glu Gly Pro Ser Gly Gly
            420                 425                 430         
Pro Gly Gly Thr Asp Gly Ala Gln Ala Ser Pro Ala Arg Gly Gly Arg
        435                 440                 445             
Lys Pro Ser Pro Pro Glu Ala Ala Ser Pro Arg Lys Ala Val Gly Thr
    450                 455                 460                 
Pro Met Ala Ala Ser Thr Pro Arg Gly Ser Ser Gly Pro Asp Thr His
465                 470                 475                 480 
Gln Gly Thr Pro Glu Pro Cys Lys Ala Ile Val Trp Gly Asp Gln Arg
                485                 490                 495     
Glu Asp Ser Ser Ala Trp Pro Glu Leu Leu Val Pro Glu Lys Ala Ala
            500                 505                 510         
Val Ser Gly Gly Arg Arg Pro Leu Pro Ser Pro Ala Pro Pro Pro Pro
        515                 520                 525             
Gln Leu Leu Glu Ala Cys Arg Ala Pro Glu Glu Pro Gly Gly Gly Gly
    530                 535                 540                 
Thr Asp Gly Val Ala Arg Thr Pro Pro Val Gly Met Ser Gly Gln Val
545                 550                 555                 560 
Ala Gly Ser Pro Met Leu Pro Gly Ala Thr Cys Pro Arg Leu Ala Ala
                565                 570                 575     
Gly Ser Arg Cys Pro Glu Arg Gly Leu Leu Thr Thr Thr Val Thr Leu
            580                 585                 590         
Gln Arg Pro Val Glu Leu Asn Gly Glu Asp Glu Leu Val Phe Thr Val
        595                 600                 605             
Val Glu Glu Leu Ser Leu Gly Ala Leu Ala Gly Ala Gly Arg Pro Thr
    610                 615                 620                 
Ser Leu Ala Ser Phe Asp Ser Asp Cys Ser Leu Arg Ala Leu Ala Ser
625                 630                 635                 640 
Gly Ser Arg Pro Val Ser Ile Ile Ser Ser Ile Asn Asp Glu Phe Asp
                645                 650                 655     
Ala Tyr Thr Ser Gln Ala Pro Glu Gly Gly Pro Leu Glu Gly Ala Ala
            660                 665                 670         
Trp Ala Gly Ser Ser His Gly Ser Ser Ile Ser Ser Trp Leu Ser Glu
        675                 680                 685             
Val Ser Val Cys Thr Ala Asp Ser Arg Asp Pro Thr Pro Gln Pro Arg
    690                 695                 700                 
Phe Ser Pro Asp Ser Leu Ala Gly Leu Asp Pro Gly Gly Pro Pro Ala
705                 710                 715                 720 
Leu Asp Gly Ser Leu Gly Asp Gly Ser Ser Gly Phe Leu Gly Pro Asp
                725                 730                 735     
Arg Pro Asp Ser Pro Gly Pro Thr Trp Gly Pro Cys Pro Gly Glu Val
            740                 745                 750         
Ala Ala Val Ala Pro Ser Arg Pro Gly Arg Glu Pro Gln Ala Gly Pro
        755                 760                 765             
Ser Arg Trp Ala Ser Ala Ala Gln Thr Ile His Ser Ser Leu Pro Arg
    770                 775                 780                 
Lys Pro Arg Thr Ala Ser Ala Thr Thr Arg Val Gly Cys Ala Arg Leu
785                 790                 795                 800 
Gly Gln Ser Pro Pro Gly Arg Gly Gly Leu Phe Glu Asp Pro Trp Leu
                805                 810                 815     
Leu Arg Val Gly Glu Cys Asp Thr Gln Ala Ala Ser Ala Gly Arg Ala
            820                 825                 830         
Pro Ser Pro Thr Leu Gly Ser Pro Arg Leu Pro Glu Ala Gln Val Met
        835                 840                 845             
Leu Ala Cys Ala Gln Arg Val Val Asp Gly Cys Glu Val Ala Ala Arg
    850                 855                 860                 
Ala Ala Arg Arg Pro Glu Ala Val Ala Arg Ile Pro Pro Leu Arg Arg
865                 870                 875                 880 
Gly Ala Thr Thr Leu Gly Val Thr Thr Pro Ala Val Ser Trp Gly Asp
                885                 890                 895     
Ala Pro Thr Glu Val Val Ala Cys Ser Gly Ser Leu Lys Ala Ser Pro
            900                 905                 910         
Thr Ser Lys Lys Gly Leu Ala Pro Lys Ala Gly Phe Leu Pro Arg Pro
        915                 920                 925             
Ser Gly Ala Ala Pro Pro Ala Pro Pro Thr Arg Lys Ser Ser Leu Glu
    930                 935                 940                 
Gln Arg Ser Ser Pro Ala Ser Ala Pro Pro His Ala Val Asn Pro Ala
945                 950                 955                 960 
Arg Val Gly Ala Ala Ala Val Leu Arg Gly Glu Glu Glu Pro Arg Pro
                965                 970                 975     
Ser Ser Arg Ala Asp His Ser Val Pro Arg Ala Thr Ser Ser Leu Lys
            980                 985                 990         
Ala Arg Ala Ser Lys Val Glu Ala Ala His Arg Leu Ala Gly His Ala
        995                 1000                1005            
Ser Leu Glu Arg Tyr Glu Gly Leu Ala His Ser Ser Ser Lys Gly Arg
    1010                1015                1020                
Glu Ala Pro Gly Arg Pro Pro Arg Ala Val Pro Lys Leu Gly Val Pro
1025                1030                1035                1040
Pro Ser Ser Pro Thr His Gly Pro Ala Pro Ala Cys Arg Ser Gly Ala
                1045                1050                1055    
Ala Lys Ala Val Gly Ala Pro Lys Pro Pro Val Gly Gly Gly Lys Gly
            1060                1065                1070        
Arg Gly Leu Val Ala Gly Gly Ser Arg Ala Leu Gly Pro Ser Val Lys
        1075                1080                1085            
Leu Ser Thr Ala Ser Val Thr Gly Arg Ser Pro Gly Gly Pro Val Ala
    1090                1095                1100                
Gly Pro Arg Ala Ala Pro Arg Ala Gly Pro Ser Val Gly Ala Lys Ala
1105                1110                1115                1120
Gly Arg Gly Thr Val Met Gly Thr Lys Gln Ala Leu Arg Ala Ala His
                1125                1130                1135    
Ser Arg Val His Glu Leu Ser Ala Ser Gly Ala Pro Gly Arg Gly Gly
            1140                1145                1150        
Ser Ser Trp Gly Ser Ala Asp Ser Asp Ser Gly His Asp Ser Gly Val
        1155                1160                1165            
Asn Val Gly Glu Glu Arg Pro Pro Thr Gly Pro Ala Leu Pro Ser Pro
    1170                1175                1180                
Tyr Ser Lys Val Thr Ala Pro Arg Arg Pro Gln Arg Tyr Ser Ser Gly
1185                1190                1195                1200
His Gly Ser Asp Asn Ser Ser Val Leu Ser Gly Glu Leu Pro Pro Ala
                1205                1210                1215    
Met Gly Arg Thr Ala Leu Phe His His Ser Gly Gly Ser Ser Gly Tyr
            1220                1225                1230        
Glu Ser Leu Arg Arg Asp Ser Glu Ala Thr Gly Ser Ala Ser Ser Ala
        1235                1240                1245            
Pro Asp Ser Met Ser Glu Ser Gly Ala Ala Ser Pro Gly Ala Arg Thr
    1250                1255                1260                
Arg Ser Leu Lys Ser Pro Lys Lys Arg Ala Thr Gly Leu Gln Arg Arg
1265                1270                1275                1280
Arg Leu Ile Pro Ala Pro Leu Pro Asp Thr Thr Ala Leu Gly Arg Lys
                1285                1290                1295    
Pro Ser Leu Pro Gly Gln Trp Val Asp Leu Pro Pro Pro Leu Ala Gly
            1300                1305                1310        
Ser Leu Lys Glu Pro Phe Glu Ile Lys Val Tyr Glu Ile Asp Asp Val
        1315                1320                1325            
Glu Arg Leu Gln Arg Pro Arg Pro Thr Pro Arg Glu Ala Pro Thr Gln
    1330                1335                1340                
Gly Leu Ala Cys Val Ser Thr Arg Leu Arg Leu Ala Glu Arg Arg Gln
1345                1350                1355                1360
Gln Arg Leu Arg Glu Val Gln Ala Lys His Lys His Leu Cys Glu Glu
                1365                1370                1375    
Leu Ala Glu Thr Gln Gly Arg Leu Met Leu Glu Pro Gly Arg Trp Leu
            1380                1385                1390        
Glu Gln Phe Glu Val Asp Pro Glu Leu Glu Pro Glu Ser Ala Glu Tyr
        1395                1400                1405            
Leu Ala Ala Leu Glu Arg Ala Thr Ala Ala Leu Glu Gln Cys Val Asn
    1410                1415                1420                
Leu Cys Lys Ala His Val Met Met Val Thr Cys Phe Asp Ile Ser Val
1425                1430                1435                1440
Ala Ala Ser Ala Ala Ile Pro Gly Pro Gln Glu Val Asp Val
                1445                1450                


<210> 2055
<211> 207
<212> PRT
<213> Homo sapiens

<400> 2055
Met Thr Ser Arg Lys Lys Val Leu Leu Lys Val Ile Ile Leu Gly Asp
 1               5                  10                  15      
Ser Gly Val Gly Lys Thr Ser Leu Met Asn Gln Tyr Val Asn Lys Lys
            20                  25                  30          
Phe Ser Asn Gln Tyr Lys Ala Thr Ile Gly Ala Asp Phe Leu Thr Lys
        35                  40                  45              
Glu Val Met Val Asp Asp Arg Leu Val Thr Met Gln Ile Trp Asp Thr
    50                  55                  60                  
Ala Gly Gln Glu Arg Phe Gln Ser Leu Gly Val Ala Phe Tyr Arg Gly
65                  70                  75                  80  
Ala Asp Cys Cys Val Leu Val Phe Asp Val Thr Ala Pro Asn Thr Phe
                85                  90                  95      
Lys Thr Leu Asp Ser Trp Arg Asp Glu Phe Leu Ile Gln Ala Ser Pro
            100                 105                 110         
Arg Asp Pro Glu Asn Phe Pro Phe Val Val Leu Gly Asn Lys Ile Asp
        115                 120                 125             
Leu Glu Asn Arg Gln Val Ala Thr Lys Arg Ala Gln Ala Trp Cys Tyr
    130                 135                 140                 
Ser Lys Asn Asn Ile Pro Tyr Phe Glu Thr Ser Ala Lys Glu Ala Ile
145                 150                 155                 160 
Asn Val Glu Gln Ala Phe Gln Thr Ile Ala Arg Asn Ala Leu Lys Gln
                165                 170                 175     
Glu Thr Glu Val Glu Leu Tyr Asn Glu Phe Pro Glu Pro Ile Lys Leu
            180                 185                 190         
Asp Lys Asn Asp Arg Ala Lys Ala Ser Ala Glu Ser Cys Ser Cys
        195                 200                 205         


<210> 2056
<211> 467
<212> PRT
<213> Homo sapiens

<400> 2056
Met Leu Arg Ser Ser Leu Lys Gln Tyr Ser Phe Glu Ala Leu Arg Glu
 1               5                  10                  15      
Lys Ser Asn Tyr Ser Asp Ile Pro Asp Val Lys Asn Asp Phe Ala Phe
            20                  25                  30          
Ile Leu His Leu Ala Asp Gln Tyr Asp Pro Leu Tyr Ser Lys Arg Phe
        35                  40                  45              
Ser Ile Phe Leu Ser Glu Val Ser Glu Asn Lys Leu Lys Gln Ile Asn
    50                  55                  60                  
Leu Asn Asn Glu Trp Thr Val Glu Lys Leu Lys Ser Lys Leu Val Lys
65                  70                  75                  80  
Asn Ala Gln Asp Lys Ile Glu Leu His Leu Phe Met Leu Asn Gly Leu
                85                  90                  95      
Pro Asp Asn Val Phe Glu Leu Thr Glu Met Glu Val Leu Ser Leu Glu
            100                 105                 110         
Leu Ile Pro Glu Val Lys Leu Pro Ser Ala Val Ser Gln Leu Val Asn
        115                 120                 125             
Leu Lys Glu Leu Arg Val Tyr His Ser Ser Leu Val Val Asp His Pro
    130                 135                 140                 
Ala Leu Ala Phe Leu Glu Glu Asn Leu Lys Ile Leu Arg Leu Lys Phe
145                 150                 155                 160 
Thr Glu Met Gly Lys Ile Pro Arg Trp Val Phe His Leu Lys Asn Leu
                165                 170                 175     
Lys Glu Leu Tyr Leu Ser Gly Cys Val Leu Pro Glu Gln Leu Ser Thr
            180                 185                 190         
Met Gln Leu Glu Gly Phe Gln Asp Leu Lys Asn Leu Arg Thr Leu Tyr
        195                 200                 205             
Leu Lys Ser Ser Leu Ser Arg Ile Pro Gln Val Val Thr Asp Leu Leu
    210                 215                 220                 
Pro Ser Leu Gln Lys Leu Ser Leu Asp Asn Glu Gly Ser Lys Leu Val
225                 230                 235                 240 
Val Leu Asn Asn Leu Lys Lys Met Val Asn Leu Lys Ser Leu Glu Leu
                245                 250                 255     
Ile Ser Cys Asp Leu Glu Arg Ile Pro His Ser Ile Phe Ser Leu Asn
            260                 265                 270         
Asn Leu His Glu Leu Asp Leu Arg Glu Asn Asn Leu Lys Thr Val Glu
        275                 280                 285             
Glu Ile Ile Ser Phe Gln His Leu Gln Asn Leu Ser Cys Leu Lys Leu
    290                 295                 300                 
Trp His Asn Asn Ile Ala Tyr Ile Pro Ala Gln Ile Gly Ala Leu Ser
305                 310                 315                 320 
Asn Leu Glu Gln Leu Ser Leu Asp His Asn Asn Ile Glu Asn Leu Pro
                325                 330                 335     
Leu Gln Leu Phe Leu Cys Thr Lys Leu His Tyr Leu Asp Leu Ser Tyr
            340                 345                 350         
Asn His Leu Thr Phe Ile Pro Glu Glu Ile Gln Tyr Leu Ser Asn Leu
        355                 360                 365             
Gln Tyr Phe Ala Val Thr Asn Asn Asn Ile Glu Met Leu Pro Asp Gly
    370                 375                 380                 
Leu Phe Gln Cys Lys Lys Leu Gln Cys Leu Leu Leu Gly Lys Asn Ser
385                 390                 395                 400 
Leu Met Asn Leu Ser Pro His Val Gly Glu Leu Ser Asn Leu Thr His
                405                 410                 415     
Leu Glu Leu Ile Gly Asn Tyr Leu Glu Thr Leu Pro Pro Glu Leu Glu
            420                 425                 430         
Gly Cys Gln Ser Leu Lys Arg Asn Cys Leu Ile Val Glu Glu Asn Leu
        435                 440                 445             
Leu Asn Thr Leu Pro Leu Pro Val Thr Glu Arg Leu Gln Thr Cys Leu
    450                 455                 460                 
Asp Lys Cys
465         


<210> 2057
<211> 678
<212> PRT
<213> Homo sapiens

<400> 2057
Met Ala Val Lys Val Gln Thr Thr Lys Arg Gly Asp Pro His Glu Leu
 1               5                  10                  15      
Arg Asn Ile Phe Leu Gln Tyr Ala Ser Thr Glu Val Asp Gly Glu Arg
            20                  25                  30          
Tyr Met Thr Pro Glu Asp Phe Val Gln Arg Tyr Leu Gly Leu Tyr Asn
        35                  40                  45              
Asp Pro Asn Ser Asn Pro Lys Ile Val Gln Leu Leu Ala Gly Val Ala
    50                  55                  60                  
Asp Gln Thr Lys Asp Gly Leu Ile Ser Tyr Gln Glu Phe Leu Ala Phe
65                  70                  75                  80  
Glu Ser Val Leu Cys Ala Pro Asp Ser Met Phe Ile Val Ala Phe Gln
                85                  90                  95      
Leu Phe Asp Lys Ser Gly Asn Gly Glu Val Thr Phe Glu Asn Val Lys
            100                 105                 110         
Glu Ile Phe Gly Gln Thr Ile Ile His His His Ile Pro Phe Asn Trp
        115                 120                 125             
Asp Cys Glu Phe Ile Arg Leu His Phe Gly His Asn Arg Lys Lys His
    130                 135                 140                 
Leu Asn Tyr Thr Glu Phe Thr Gln Phe Leu Gln Glu Leu Gln Leu Glu
145                 150                 155                 160 
His Ala Arg Gln Ala Phe Ala Leu Lys Asp Lys Ser Lys Ser Gly Met
                165                 170                 175     
Ile Ser Gly Leu Asp Phe Ser Asp Ile Met Val Thr Ile Arg Ser His
            180                 185                 190         
Met Leu Thr Pro Phe Val Glu Glu Asn Leu Val Ser Ala Ala Gly Gly
        195                 200                 205             
Ser Ile Ser His Gln Val Ser Phe Ser Tyr Phe Asn Ala Phe Asn Ser
    210                 215                 220                 
Leu Leu Asn Asn Met Glu Leu Val Arg Lys Ile Tyr Ser Thr Leu Ala
225                 230                 235                 240 
Gly Thr Arg Lys Asp Val Glu Val Thr Lys Glu Glu Phe Ala Gln Ser
                245                 250                 255     
Ala Ile Arg Tyr Gly Gln Val Thr Pro Leu Glu Ile Asp Ile Leu Tyr
            260                 265                 270         
Gln Leu Ala Asp Leu Tyr Asn Ala Ser Gly Arg Leu Thr Leu Ala Asp
        275                 280                 285             
Ile Glu Arg Ile Ala Pro Leu Ala Glu Gly Ala Leu Pro Tyr Asn Leu
    290                 295                 300                 
Ala Glu Leu Gln Arg Gln Gln Ser Pro Gly Leu Gly Arg Pro Ile Trp
305                 310                 315                 320 
Leu Gln Ile Ala Glu Ser Ala Tyr Arg Phe Thr Leu Gly Ser Val Ala
                325                 330                 335     
Gly Ala Val Gly Ala Thr Ala Val Tyr Pro Ile Asp Leu Val Lys Thr
            340                 345                 350         
Arg Met Gln Asn Gln Arg Gly Ser Gly Ser Val Val Gly Glu Leu Met
        355                 360                 365             
Tyr Lys Asn Ser Phe Asp Cys Phe Lys Lys Val Leu Arg Tyr Glu Gly
    370                 375                 380                 
Phe Phe Gly Leu Tyr Arg Gly Leu Ile Pro Gln Leu Ile Gly Val Ala
385                 390                 395                 400 
Pro Glu Lys Ala Ile Lys Leu Thr Val Asn Asp Phe Val Arg Asp Lys
                405                 410                 415     
Phe Thr Arg Arg Asp Gly Ser Val Pro Leu Pro Ala Glu Val Leu Ala
            420                 425                 430         
Gly Gly Cys Ala Gly Gly Ser Gln Val Ile Phe Thr Asn Pro Leu Glu
        435                 440                 445             
Ile Val Lys Ile Arg Leu Gln Val Ala Gly Glu Ile Thr Thr Gly Pro
    450                 455                 460                 
Arg Val Ser Ala Leu Asn Val Leu Arg Asp Leu Gly Ile Phe Gly Leu
465                 470                 475                 480 
Tyr Lys Gly Ala Lys Ala Cys Phe Leu Arg Asp Ile Pro Phe Ser Ala
                485                 490                 495     
Ile Tyr Phe Pro Val Tyr Ala His Cys Lys Leu Leu Leu Ala Asp Glu
            500                 505                 510         
Asn Gly His Val Gly Gly Leu Asn Leu Leu Ala Ala Gly Ala Met Ala
        515                 520                 525             
Gly Val Pro Ala Ala Ser Leu Val Thr Pro Ala Asp Val Ile Lys Thr
    530                 535                 540                 
Arg Leu Gln Val Ala Ala Arg Ala Gly Gln Thr Thr Tyr Ser Gly Val
545                 550                 555                 560 
Ile Asp Cys Phe Arg Lys Ile Leu Arg Glu Glu Gly Pro Ser Ala Phe
                565                 570                 575     
Trp Lys Gly Thr Ala Ala Arg Val Phe Arg Ser Ser Pro Gln Phe Gly
            580                 585                 590         
Val Thr Leu Val Thr Tyr Glu Leu Leu Gln Arg Trp Phe Tyr Ile Asp
        595                 600                 605             
Phe Gly Gly Leu Lys Pro Ala Gly Ser Glu Pro Thr Pro Lys Ser Arg
    610                 615                 620                 
Ile Ala Asp Leu Pro Pro Ala Asn Pro Asp His Ile Gly Gly Tyr Arg
625                 630                 635                 640 
Leu Ala Thr Ala Thr Phe Ala Gly Ile Glu Asn Lys Phe Gly Leu Tyr
                645                 650                 655     
Leu Pro Lys Phe Lys Ser Pro Ser Val Ala Val Val Gln Pro Lys Ala
            660                 665                 670         
Ala Val Ala Ala Thr Gln
        675             


<210> 2058
<211> 152
<212> PRT
<213> Homo sapiens

<400> 2058
Met Glu Ala Val Leu Asn Glu Leu Val Ser Val Glu Asp Leu Leu Lys
 1               5                  10                  15      
Phe Glu Lys Lys Phe Gln Ser Glu Lys Ala Ala Gly Ser Val Ser Lys
            20                  25                  30          
Ser Thr Gln Phe Glu Tyr Ala Trp Cys Leu Val Arg Ser Lys Tyr Asn
        35                  40                  45              
Asp Asp Ile Arg Lys Gly Ile Val Leu Leu Glu Glu Leu Leu Pro Lys
    50                  55                  60                  
Gly Ser Lys Glu Glu Gln Arg Asp Tyr Val Phe Tyr Leu Ala Val Gly
65                  70                  75                  80  
Asn Tyr Arg Leu Lys Glu Tyr Glu Lys Ala Leu Lys Tyr Val Arg Gly
                85                  90                  95      
Leu Leu Gln Thr Glu Pro Gln Asn Asn Gln Ala Lys Glu Leu Glu Arg
            100                 105                 110         
Leu Ile Asp Lys Ala Met Lys Lys Asp Gly Leu Val Gly Met Ala Ile
        115                 120                 125             
Val Gly Gly Met Ala Leu Gly Val Ala Gly Leu Ala Gly Leu Ile Gly
    130                 135                 140                 
Leu Ala Val Ser Lys Ser Lys Ser
145                 150         


<210> 2059
<211> 356
<212> PRT
<213> Homo sapiens

<400> 2059
Met Thr Gln Val Asp Gln Glu Asp Ile Thr Leu Gln Ser Gly Arg Asp
 1               5                  10                  15      
Glu Leu Asn Glu Glu Leu Ile Gln Glu Glu Ser Ser Glu Asp Glu Gly
            20                  25                  30          
Glu Tyr Glu Glu Val Arg Lys Asp Gln Asp Ser Val Gly Glu Met Lys
        35                  40                  45              
Asp Glu Gly Glu Glu Thr Leu Asn Tyr Pro Asp Thr Thr Ile Asp Leu
    50                  55                  60                  
Ser His Leu Gln Pro Gln Arg Ser Ile Gln Lys Leu Ala Ser Lys Glu
65                  70                  75                  80  
Glu Ser Ser Asn Ser Ser Asp Ser Lys Ser Gln Ser Arg Arg His Leu
                85                  90                  95      
Ser Ala Lys Glu Arg Arg Glu Met Lys Lys Lys Lys Leu Pro Ser Asp
            100                 105                 110         
Ser Gly Asp Leu Glu Ala Leu Glu Gly Lys Asp Lys Glu Lys Glu Ser
        115                 120                 125             
Thr Val His Ile Glu Thr His Gln Asn Thr Ser Lys Asn Val Ala Ala
    130                 135                 140                 
Val Gln Pro Met Lys Arg Gly Gln Lys Ser Lys Met Lys Lys Met Lys
145                 150                 155                 160 
Glu Lys Tyr Lys Asp Gln Asp Glu Glu Asp Arg Glu Leu Ile Met Lys
                165                 170                 175     
Leu Leu Gly Ser Ala Gly Ser Asn Lys Glu Glu Lys Gly Lys Lys Gly
            180                 185                 190         
Lys Lys Gly Lys Thr Lys Asp Glu Pro Val Lys Lys Gln Pro Gln Lys
        195                 200                 205             
Pro Arg Gly Gly Gln Arg Val Ser Asp Asn Ile Lys Lys Glu Thr Pro
    210                 215                 220                 
Phe Leu Glu Val Ile Thr His Glu Leu Gln Asp Phe Ala Val Asp Asp
225                 230                 235                 240 
Pro His Asp Asp Lys Glu Glu Gln Asp Leu Asp Gln Gln Gly Asn Glu
                245                 250                 255     
Glu Asn Leu Phe Asp Ser Leu Thr Gly Gln Pro His Pro Glu Asp Val
            260                 265                 270         
Leu Leu Phe Ala Ile Pro Ile Cys Ala Pro Tyr Thr Thr Met Thr Asn
        275                 280                 285             
Tyr Lys Tyr Lys Val Lys Leu Thr Pro Gly Val Gln Lys Lys Gly Lys
    290                 295                 300                 
Ala Ala Lys Thr Ala Leu Asn Ser Phe Met His Ser Lys Glu Ala Thr
305                 310                 315                 320 
Ala Arg Glu Lys Asp Leu Phe Arg Ser Val Lys Asp Thr Asp Leu Ser
                325                 330                 335     
Arg Asn Ile Pro Gly Lys Val Lys Val Ser Ala Pro Asn Leu Leu Asn
            340                 345                 350         
Val Lys Arg Lys
        355     


<210> 2060
<211> 166
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 3, 4, 5, 6, 7, 8, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41,
42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55,
56
<223> Xaa = Any Amino Acid

<400> 2060
Met Asn Xaa Xaa Xaa Xaa Xaa Xaa Phe Asp Ile Ile Gly Leu Ser Pro
 1               5                  10                  15      
Asp Ser Gln Glu Asp Glu Ser Gly Ile Lys Gln Ala Ala Glu Asn Xaa
            20                  25                  30          
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
        35                  40                  45              
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Gly Ala Leu Ser Leu Tyr Thr
    50                  55                  60                  
Ala Leu Thr Thr Gln Gln Lys Leu Ala Gly Val Thr Ala Leu Ser Cys
65                  70                  75                  80  
Trp Leu Pro Leu Arg Ala Ser Phe Pro Gln Gly Pro Ile Gly Gly Ala
                85                  90                  95      
Asn Arg Asp Ile Ser Ile Leu Gln Cys His Gly Asp Cys Asp Pro Leu
            100                 105                 110         
Val Pro Leu Met Phe Gly Ser Leu Thr Val Glu Lys Leu Lys Thr Leu
        115                 120                 125             
Val Asn Pro Ala Asn Val Thr Phe Lys Thr Tyr Glu Gly Met Met His
    130                 135                 140                 
Ser Ser Cys Gln Gln Glu Met Met Asp Val Lys Gln Phe Ile Asp Lys
145                 150                 155                 160 
Leu Leu Pro Pro Ile Asp
                165     


<210> 2061
<211> 794
<212> PRT
<213> Homo sapiens

<400> 2061
Met Ala Asp Ala Trp Glu Glu Ile Arg Arg Leu Ala Ala Asp Phe Gln
 1               5                  10                  15      
Arg Ala Gln Phe Ala Glu Ala Thr Gln Arg Leu Ser Glu Arg Asn Cys
            20                  25                  30          
Ile Glu Ile Val Asn Lys Leu Ile Ala Gln Lys Gln Leu Glu Val Val
        35                  40                  45              
His Thr Leu Asp Gly Lys Glu Tyr Ile Thr Pro Ala Gln Ile Ser Lys
    50                  55                  60                  
Glu Met Arg Asp Glu Leu His Val Arg Gly Gly Arg Val Asn Ile Val
65                  70                  75                  80  
Asp Leu Gln Gln Val Ile Asn Val Asp Leu Ile His Ile Glu Asn Arg
                85                  90                  95      
Ile Gly Asp Ile Ile Lys Ser Glu Lys His Val Gln Leu Val Leu Gly
            100                 105                 110         
Gln Leu Ile Asp Glu Asn Tyr Leu Asp Arg Leu Ala Glu Glu Val Asn
        115                 120                 125             
Asp Lys Leu Gln Glu Ser Gly Gln Val Thr Ile Ser Glu Leu Cys Lys
    130                 135                 140                 
Thr Tyr Asp Leu Pro Gly Asn Phe Leu Thr Gln Ala Leu Thr Gln Arg
145                 150                 155                 160 
Leu Gly Arg Ile Ile Ser Gly His Ile Asp Leu Asp Asn Arg Gly Val
                165                 170                 175     
Ile Phe Thr Glu Ala Phe Val Ala Arg His Lys Ala Arg Ile Arg Gly
            180                 185                 190         
Leu Phe Ser Ala Ile Thr Arg Pro Thr Ala Val Asn Ser Leu Ile Ser
        195                 200                 205             
Lys Tyr Gly Phe Gln Glu Gln Leu Leu Tyr Ser Val Leu Glu Glu Leu
    210                 215                 220                 
Val Asn Ser Gly Arg Leu Arg Gly Thr Val Val Gly Gly Arg Gln Asp
225                 230                 235                 240 
Lys Ala Val Phe Val Pro Asp Ile Tyr Ser Arg Thr Gln Ser Thr Trp
                245                 250                 255     
Val Asp Ser Phe Phe Arg Gln Asn Gly Tyr Leu Glu Phe Asp Ala Leu
            260                 265                 270         
Ser Arg Leu Gly Ile Pro Asp Ala Val Ser Tyr Ile Lys Lys Arg Tyr
        275                 280                 285             
Lys Thr Thr Gln Leu Leu Phe Leu Lys Ala Ala Cys Val Gly Gln Gly
    290                 295                 300                 
Leu Val Asp Gln Val Glu Ala Ser Val Glu Glu Ala Ile Ser Ser Gly
305                 310                 315                 320 
Thr Trp Val Asp Ile Ala Pro Leu Leu Pro Thr Ser Leu Ser Val Glu
                325                 330                 335     
Asp Ala Ala Ile Leu Leu Gln Gln Val Met Arg Ala Phe Ser Lys Gln
            340                 345                 350         
Ala Ser Thr Val Val Phe Ser Asp Thr Val Val Val Ser Glu Lys Phe
        355                 360                 365             
Ile Asn Asp Cys Thr Glu Leu Phe Arg Glu Leu Met His Gln Lys Ala
    370                 375                 380                 
Glu Lys Glu Met Lys Asn Asn Pro Val His Leu Ile Thr Glu Glu Asp
385                 390                 395                 400 
Leu Lys Gln Ile Ser Thr Leu Glu Ser Val Ser Thr Ser Lys Lys Asp
                405                 410                 415     
Lys Lys Asp Glu Arg Arg Arg Lys Ala Thr Glu Gly Ser Gly Ser Met
            420                 425                 430         
Arg Gly Gly Gly Gly Gly Asn Ala Arg Glu Tyr Lys Ile Lys Lys Val
        435                 440                 445             
Lys Lys Lys Gly Arg Lys Asp Asp Asp Ser Asp Asp Glu Ser Gln Ser
    450                 455                 460                 
Ser His Thr Gly Lys Lys Lys Pro Glu Ile Ser Phe Met Phe Gln Asp
465                 470                 475                 480 
Glu Ile Glu Asp Phe Leu Arg Lys His Ile Gln Asp Ala Pro Glu Glu
                485                 490                 495     
Phe Ile Ser Glu Leu Ala Glu Tyr Leu Ile Lys Pro Leu Asn Lys Thr
            500                 505                 510         
Tyr Leu Glu Val Val Arg Ser Val Phe Met Ser Ser Thr Thr Ser Ala
        515                 520                 525             
Ser Gly Thr Gly Arg Lys Arg Thr Ile Lys Asp Leu Gln Glu Glu Val
    530                 535                 540                 
Ser Asn Leu Tyr Asn Asn Ile Arg Leu Phe Glu Lys Gly Met Lys Phe
545                 550                 555                 560 
Phe Ala Asp Asp Thr Gln Ala Ala Leu Thr Lys His Leu Leu Lys Ser
                565                 570                 575     
Val Cys Thr Asp Ile Thr Asn Leu Ile Phe Asn Phe Leu Ala Ser Asp
            580                 585                 590         
Leu Met Met Ala Val Asp Asp Pro Ala Ala Ile Thr Ser Glu Ile Arg
        595                 600                 605             
Lys Lys Ile Leu Ser Lys Leu Ser Glu Glu Thr Lys Val Ala Leu Thr
    610                 615                 620                 
Lys Leu His Asn Ser Leu Asn Glu Lys Ser Ile Glu Asp Phe Ile Ser
625                 630                 635                 640 
Cys Leu Asp Ser Ala Ala Glu Ala Cys Asp Ile Met Val Lys Arg Gly
                645                 650                 655     
Asp Lys Lys Arg Glu Arg Gln Ile Leu Phe Gln His Arg Gln Ala Leu
            660                 665                 670         
Ala Glu Gln Leu Lys Val Thr Glu Asp Pro Ala Leu Ile Leu His Leu
        675                 680                 685             
Thr Ser Val Leu Leu Phe Gln Phe Ser Thr His Ser Met Leu His Ala
    690                 695                 700                 
Pro Gly Arg Cys Val Pro Gln Ile Ile Ala Phe Leu Asn Ser Lys Ile
705                 710                 715                 720 
Pro Glu Asp Gln His Ala Leu Leu Val Lys Tyr Gln Gly Leu Val Val
                725                 730                 735     
Lys Gln Leu Val Ser Gln Ser Lys Lys Thr Gly Gln Gly Asp Tyr Pro
            740                 745                 750         
Leu Asn Asn Glu Leu Asp Lys Glu Gln Glu Asp Val Ala Ser Thr Thr
        755                 760                 765             
Arg Lys Glu Leu Gln Glu Leu Ser Ser Ser Ile Lys Asp Leu Val Leu
    770                 775                 780                 
Lys Ser Arg Lys Ser Ser Val Thr Glu Glu
785                 790                 


<210> 2062
<211> 1085
<212> PRT
<213> Homo sapiens

<400> 2062
Met Gly Tyr Met Gly Glu Met Glu Val Gln Gly Pro Thr Arg Glu Ser
 1               5                  10                  15      
Gly Gln Ser Leu Pro Pro Gln Lys Lys Ala Tyr Leu Ser His Leu Ser
            20                  25                  30          
Thr Gly Ser Gly His Ile Glu Gly Asp Trp Ala Gly Arg Asn Arg Lys
        35                  40                  45              
Leu Leu Lys Pro Arg Ser Ile Gln Lys Ser Trp Phe Val Gln Phe Pro
    50                  55                  60                  
Trp Leu Ile Met Asn Glu Glu Gln Thr Ala Leu Phe Cys Ser Ala Cys
65                  70                  75                  80  
Arg Glu Tyr Pro Ser Ile Arg Asp Lys Arg Ser Arg Leu Ile Glu Gly
                85                  90                  95      
Tyr Thr Gly Pro Phe Lys Val Glu Thr Leu Lys Tyr His Ala Lys Ser
            100                 105                 110         
Lys Ala His Met Phe Cys Val Asn Ala Leu Ala Ala Arg Asp Pro Ile
        115                 120                 125             
Trp Ala Ala Arg Phe Arg Ser Ile Arg Asp Pro Pro Gly Asp Val Leu
    130                 135                 140                 
Ala Ser Pro Glu Pro Leu Phe Thr Ala Asp Cys Pro Ile Phe Tyr Pro
145                 150                 155                 160 
Pro Gly Pro Leu Gly Gly Phe Asp Ser Met Ala Glu Leu Leu Pro Ser
                165                 170                 175     
Ser Arg Ala Glu Leu Glu Asp Pro Gly Gly Asp Gly Ala Ile Pro Ala
            180                 185                 190         
Met Tyr Leu Asp Cys Ile Ser Asp Leu Arg Gln Lys Glu Ile Thr Asp
        195                 200                 205             
Gly Ile His Ser Ser Ser Asp Ile Asn Ile Leu Tyr Asn Asp Ala Val
    210                 215                 220                 
Glu Ser Cys Ile Gln Asp Pro Ser Ala Glu Gly Leu Ser Glu Glu Val
225                 230                 235                 240 
Pro Val Val Phe Glu Glu Leu Pro Val Val Phe Glu Asp Val Ala Val
                245                 250                 255     
Tyr Phe Thr Arg Glu Glu Trp Gly Met Leu Asp Lys Arg Gln Lys Glu
            260                 265                 270         
Leu Tyr Arg Asp Val Met Arg Met Asn Tyr Glu Leu Leu Ala Ser Leu
        275                 280                 285             
Gly Pro Ala Ala Ala Lys Pro Asp Leu Ile Ser Lys Leu Glu Arg Arg
    290                 295                 300                 
Ala Ala Pro Trp Ile Lys Asp Pro Asn Gly Pro Lys Trp Gly Lys Gly
305                 310                 315                 320 
Arg Pro Pro Gly Asn Lys Lys Met Val Ala Val Arg Glu Ala Asp Thr
                325                 330                 335     
Gln Ala Ser Ala Ala Asp Ser Ala Leu Leu Pro Gly Ser Pro Val Glu
            340                 345                 350         
Ala Arg Ala Ser Cys Cys Ser Ser Ser Ile Cys Glu Glu Gly Asp Gly
        355                 360                 365             
Pro Arg Arg Ile Lys Arg Thr Tyr Arg Pro Arg Ser Ile Gln Arg Ser
    370                 375                 380                 
Trp Phe Gly Gln Phe Pro Trp Leu Val Ile Asp Pro Lys Glu Thr Lys
385                 390                 395                 400 
Leu Phe Cys Ser Ala Cys Ile Glu Arg Pro Asn Leu His Asp Lys Ser
                405                 410                 415     
Ser Arg Leu Val Arg Gly Tyr Thr Gly Pro Phe Lys Val Glu Thr Leu
            420                 425                 430         
Lys Tyr His Glu Val Ser Lys Ala His Arg Leu Cys Val Asn Thr Val
        435                 440                 445             
Glu Ile Lys Glu Asp Thr Pro His Thr Ala Leu Val Pro Glu Ile Ser
    450                 455                 460                 
Ser Asp Leu Met Ala Asn Met Glu His Phe Phe Asn Ala Ala Tyr Ser
465                 470                 475                 480 
Ile Ala Tyr His Ser Arg Pro Leu Asn Asp Phe Glu Lys Ile Leu Gln
                485                 490                 495     
Leu Leu Gln Ser Thr Gly Thr Val Ile Leu Gly Lys Tyr Arg Asn Arg
            500                 505                 510         
Thr Ala Cys Thr Gln Phe Ile Lys Tyr Ile Ser Glu Thr Leu Lys Arg
        515                 520                 525             
Glu Ile Leu Glu Asp Val Arg Asn Ser Pro Cys Val Ser Val Leu Leu
    530                 535                 540                 
Asp Ser Ser Thr Asp Ala Ser Glu Gln Ala Cys Val Gly Ile Tyr Ile
545                 550                 555                 560 
Arg Tyr Phe Lys Gln Met Glu Val Lys Glu Ser Tyr Ile Thr Leu Ala
                565                 570                 575     
Pro Leu Tyr Ser Glu Thr Ala Asp Gly Tyr Phe Glu Thr Ile Val Ser
            580                 585                 590         
Ala Leu Asp Glu Leu Asp Ile Pro Phe Arg Lys Pro Gly Trp Val Val
        595                 600                 605             
Gly Leu Gly Thr Asp Gly Ser Ala Met Leu Ser Cys Arg Gly Gly Leu
    610                 615                 620                 
Val Glu Lys Phe Gln Glu Val Ile Pro Gln Leu Leu Pro Val His Cys
625                 630                 635                 640 
Val Ala His Arg Leu His Leu Ala Val Val Asp Ala Cys Gly Ser Ile
                645                 650                 655     
Asp Leu Val Lys Lys Cys Asp Arg His Ile Arg Thr Val Phe Lys Phe
            660                 665                 670         
Tyr Gln Ser Ser Asn Lys Arg Leu Asn Glu Leu Gln Glu Gly Ala Ala
        675                 680                 685             
Pro Leu Glu Gln Glu Ile Ile Arg Leu Lys Asp Leu Asn Ala Val Arg
    690                 695                 700                 
Trp Val Ala Ser Arg Arg Arg Thr Leu His Ala Leu Leu Val Ser Trp
705                 710                 715                 720 
Pro Ala Leu Ala Arg His Leu Gln Arg Val Ala Glu Ala Gly Gly Gln
                725                 730                 735     
Ile Gly His Arg Ala Lys Gly Met Leu Lys Leu Met Arg Gly Phe His
            740                 745                 750         
Phe Val Lys Phe Cys His Phe Leu Leu Asp Phe Leu Ser Ile Tyr Arg
        755                 760                 765             
Pro Leu Ser Glu Val Cys Gln Lys Glu Ile Val Leu Ile Thr Glu Val
    770                 775                 780                 
Asn Ala Thr Leu Gly Arg Ala Tyr Val Ala Leu Glu Ser Leu Arg His
785                 790                 795                 800 
Gln Ala Gly Pro Lys Glu Glu Glu Phe Asn Ala Ser Phe Lys Asp Gly
                805                 810                 815     
Arg Leu His Gly Ile Cys Leu Asp Lys Leu Glu Val Ala Glu Gln Arg
            820                 825                 830         
Phe Gln Ala Asp Arg Glu Arg Thr Val Leu Thr Gly Ile Glu Tyr Leu
        835                 840                 845             
Gln Gln Arg Phe Asp Ala Asp Arg Pro Pro Gln Leu Lys Asn Met Glu
    850                 855                 860                 
Val Phe Asp Thr Met Ala Trp Pro Ser Gly Ile Glu Leu Ala Ser Phe
865                 870                 875                 880 
Gly Asn Asp Asp Ile Leu Asn Leu Ala Arg Tyr Phe Glu Cys Ser Leu
                885                 890                 895     
Pro Thr Gly Tyr Ser Glu Glu Ala Leu Leu Glu Glu Trp Leu Gly Leu
            900                 905                 910         
Lys Thr Ile Ala Gln His Leu Pro Phe Ser Met Leu Cys Lys Asn Ala
        915                 920                 925             
Leu Ala Gln His Cys Arg Phe Pro Leu Leu Ser Lys Leu Met Ala Val
    930                 935                 940                 
Val Val Cys Val Pro Ile Ser Thr Ser Cys Cys Glu Arg Gly Phe Lys
945                 950                 955                 960 
Ala Met Asn Arg Ile Arg Thr Asp Glu Arg Thr Lys Leu Ser Asn Glu
                965                 970                 975     
Val Leu Asn Met Leu Met Met Thr Ala Val Asn Gly Val Ala Val Thr
            980                 985                 990         
Glu Tyr Asp Pro Gln Pro Ala Ile Gln His Trp Tyr Leu Thr Ser Ser
        995                 1000                1005            
Gly Arg Arg Phe Ser His Val Tyr Thr Cys Ala Gln Val Pro Ala Arg
    1010                1015                1020                
Ser Pro Ala Ser Ala Arg Leu Arg Lys Glu Glu Met Gly Ala Leu Tyr
1025                1030                1035                1040
Val Glu Glu Pro Arg Thr Gln Lys Pro Pro Ile Leu Pro Ser Arg Glu
                1045                1050                1055    
Ala Ala Glu Val Leu Lys Asp Cys Ile Met Glu Pro Pro Glu Arg Leu
            1060                1065                1070        
Leu Tyr Pro His Thr Ser Gln Glu Ala Pro Gly Met Ser
        1075                1080                1085


<210> 2063
<211> 1191
<212> PRT
<213> Homo sapiens

<400> 2063
Met Ser Ser Pro Met Pro Asp Cys Thr Ser Lys Cys Arg Ser Leu Lys
 1               5                  10                  15      
His Ala Leu Asp Val Leu Ser Val Val Thr Lys Gly Ser Glu Asn Gln
            20                  25                  30          
Ile Lys Ala Phe Leu Ser Ser His Cys Tyr Asn Ala Ala Thr Ile Lys
        35                  40                  45              
Asp Val Phe Gly Arg Asn Ala Leu His Leu Val Ser Ser Cys Gly Lys
    50                  55                  60                  
Lys Gly Val Leu Asp Trp Leu Ile Gln Lys Gly Val Asp Leu Leu Val
65                  70                  75                  80  
Lys Asp Lys Glu Ser Gly Trp Thr Ala Leu His Arg Ser Ile Phe Tyr
                85                  90                  95      
Gly His Ile Asp Cys Val Trp Ser Leu Leu Lys His Gly Val Ser Leu
            100                 105                 110         
Tyr Ile Gln Asp Lys Glu Gly Leu Ser Ala Leu Asp Leu Val Met Lys
        115                 120                 125             
Asp Arg Pro Thr His Val Val Phe Lys Asn Thr Asp Pro Thr Asp Val
    130                 135                 140                 
Tyr Thr Trp Gly Asp Asn Thr Asn Phe Thr Leu Gly His Gly Ser Gln
145                 150                 155                 160 
Asn Ser Lys His His Pro Glu Leu Val Asp Leu Phe Ser Arg Ser Gly
                165                 170                 175     
Ile Tyr Ile Lys Gln Val Val Leu Cys Lys Phe His Ser Val Phe Leu
            180                 185                 190         
Ser Gln Lys Gly Gln Val Tyr Thr Cys Gly His Gly Pro Gly Gly Arg
        195                 200                 205             
Leu Gly His Gly Asp Glu Gln Thr Cys Leu Val Pro Arg Leu Val Glu
    210                 215                 220                 
Gly Leu Asn Gly His Asn Cys Ser Gln Val Ala Ala Ala Lys Asp His
225                 230                 235                 240 
Thr Val Val Leu Thr Glu Asp Gly Cys Val Tyr Thr Phe Gly Leu Asn
                245                 250                 255     
Ile Phe His Gln Leu Gly Ile Ile Pro Pro Pro Ser Ser Cys Asn Val
            260                 265                 270         
Pro Arg Gln Ile Gln Ala Lys Tyr Leu Lys Gly Arg Thr Ile Ile Gly
        275                 280                 285             
Val Ala Ala Gly Arg Phe His Thr Val Leu Trp Thr Arg Glu Ala Val
    290                 295                 300                 
Tyr Thr Met Gly Leu Asn Gly Gly Gln Leu Gly Cys Leu Leu Asp Pro
305                 310                 315                 320 
Asn Gly Glu Lys Cys Val Thr Ala Pro Arg Gln Val Ser Ala Leu His
                325                 330                 335     
His Lys Asp Ile Ala Leu Ser Leu Val Ala Ala Ser Asp Gly Ala Thr
            340                 345                 350         
Val Cys Val Thr Thr Arg Gly Asp Ile Tyr Leu Leu Ala Asp Tyr Gln
        355                 360                 365             
Cys Lys Lys Met Ala Ser Lys Gln Leu Asn Leu Lys Lys Val Leu Val
    370                 375                 380                 
Ser Gly Gly His Met Glu Tyr Lys Val Asp Pro Glu His Leu Lys Glu
385                 390                 395                 400 
Asn Gly Gly Gln Lys Ile Cys Ile Leu Ala Met Asp Gly Ala Gly Arg
                405                 410                 415     
Val Phe Cys Trp Arg Ser Val Asn Ser Ser Leu Lys Gln Cys Arg Trp
            420                 425                 430         
Ala Tyr Pro Arg Gln Val Phe Ile Ser Asp Ile Ala Leu Asn Arg Asn
        435                 440                 445             
Glu Ile Leu Phe Val Thr Gln Asp Gly Glu Gly Phe Arg Gly Arg Trp
    450                 455                 460                 
Phe Glu Glu Lys Arg Lys Ser Ser Glu Lys Lys Glu Ile Leu Ser Asn
465                 470                 475                 480 
Leu His Asn Ser Ser Ser Asp Val Ser Tyr Val Ser Asp Ile Asn Ser
                485                 490                 495     
Val Tyr Glu Arg Ile Arg Leu Glu Lys Leu Thr Phe Ala His Arg Ala
            500                 505                 510         
Val Ser Val Ser Thr Asp Pro Ser Gly Cys Asn Phe Ala Ile Leu Gln
        515                 520                 525             
Ser Asp Pro Lys Thr Ser Leu Tyr Glu Ile Pro Ala Val Ser Ser Ser
    530                 535                 540                 
Ser Phe Phe Glu Glu Phe Gly Lys Leu Leu Arg Glu Ala Asp Glu Met
545                 550                 555                 560 
Asp Ser Ile His Asp Val Thr Phe Gln Val Gly Asn Arg Leu Phe Pro
                565                 570                 575     
Ala His Lys Tyr Ile Leu Ala Val His Ser Asp Phe Phe Gln Lys Leu
            580                 585                 590         
Phe Leu Ser Asp Gly Asn Thr Ser Glu Phe Thr Asp Ile Tyr Gln Lys
        595                 600                 605             
Asp Glu Asp Ser Ala Gly Cys His Leu Phe Val Val Glu Lys Val His
    610                 615                 620                 
Pro Asp Met Phe Glu Tyr Leu Leu Gln Phe Ile Tyr Thr Asp Thr Cys
625                 630                 635                 640 
Asp Phe Leu Thr His Gly Phe Lys Pro Arg Ile His Leu Asn Lys Asn
                645                 650                 655     
Pro Glu Glu Tyr Gln Gly Thr Leu Asn Ser His Leu Asn Lys Val Asn
            660                 665                 670         
Phe His Glu Asp Asp Asn Gln Lys Ser Ala Phe Glu Val Tyr Lys Ser
        675                 680                 685             
Asn Gln Ala Gln Thr Val Ser Glu Arg Gln Lys Ser Lys Pro Lys Ser
    690                 695                 700                 
Cys Lys Lys Gly Lys Asn Ile Arg Glu Asp Asp Pro Val Arg Met Leu
705                 710                 715                 720 
Gln Thr Val Ala Lys Lys Phe Asp Phe Ser Asn Leu Ser Ser Arg Leu
                725                 730                 735     
Asp Gly Val Arg Phe Glu Asn Glu Lys Ile Asn Val Ile Ala Lys Asn
            740                 745                 750         
Thr Gly Asn Lys Leu Lys Leu Ser Gln Lys Lys Cys Ser Phe Leu Cys
        755                 760                 765             
Asp Val Thr Met Lys Ser Val Asp Gly Lys Glu Phe Pro Cys His Lys
    770                 775                 780                 
Cys Val Leu Cys Ala Arg Leu Glu Tyr Phe His Ser Met Leu Ser Ser
785                 790                 795                 800 
Ser Trp Ile Glu Ala Ser Ser Cys Ala Ala Leu Glu Met Pro Ile His
                805                 810                 815     
Ser Asp Ile Leu Lys Val Ile Leu Asp Tyr Leu Tyr Thr Asp Glu Ala
            820                 825                 830         
Val Val Ile Lys Glu Ser Gln Asn Val Asp Phe Ile Cys Ser Val Leu
        835                 840                 845             
Val Val Ala Asp Gln Leu Leu Ile Thr Arg Leu Lys Glu Ile Cys Glu
    850                 855                 860                 
Val Ala Leu Thr Glu Lys Leu Thr Leu Lys Asn Ala Ala Met Leu Leu
865                 870                 875                 880 
Glu Phe Ala Ala Met Tyr Ser Ala Lys Gln Leu Lys Leu Ser Cys Leu
                885                 890                 895     
Gln Phe Ile Gly Leu Asn Met Ala Ala Leu Leu Glu Ala Arg Ser Leu
            900                 905                 910         
Asp Val Leu Ser Asp Gly Val Leu Lys Asp Leu Ser Glu Phe Tyr Arg
        915                 920                 925             
Lys Met Ile Pro Ala Met Asp Arg Arg Val Ile Thr Pro Tyr Gln Asp
    930                 935                 940                 
Gly Pro Asp Ile Ser Tyr Leu Glu Val Glu Asp Gly Asp Ile Phe Leu
945                 950                 955                 960 
Lys Glu Glu Ile Asn Met Glu Gln Asn His Ser Glu Thr Met Phe Lys
                965                 970                 975     
Lys Ala Lys Thr Lys Ala Lys Lys Lys Pro Arg Lys Arg Ser Asp Ser
            980                 985                 990         
Ser Gly Gly Tyr Asn Leu Ser Asp Ile Ile Gln Ser Pro Ser Ser Thr
        995                 1000                1005            
Gly Leu Leu Lys Ser Gly Lys Thr Asn Ser Val Glu Ser Leu Pro Glu
    1010                1015                1020                
Leu Leu Thr Ser Asp Ser Glu Gly Ser Tyr Ala Gly Val Gly Ser Pro
1025                1030                1035                1040
Arg Asp Leu Gln Ser Pro Asp Phe Thr Thr Gly Phe His Ser Asp Lys
                1045                1050                1055    
Ile Glu Ala Lys Val Lys Pro Tyr Val Asn Gly Thr Ser Pro Val Tyr
            1060                1065                1070        
Ser Arg Glu Asp Leu Lys Pro Trp Glu Lys Ser Pro Ile Leu Lys Ile
        1075                1080                1085            
Ser Ala Pro Gln Pro Ile Pro Ser Asn Arg Ile Asp Thr Thr Ser Ser
    1090                1095                1100                
Ala Ser Trp Val Ala Gly Ser Phe Ser Pro Val Ser Pro Pro Val Val
1105                1110                1115                1120
Asp Leu Arg Thr Ile Met Glu Ile Glu Glu Ser Arg Gln Lys Cys Gly
                1125                1130                1135    
Ala Thr Pro Lys Ser His Leu Gly Lys Thr Val Ser His Gly Val Lys
            1140                1145                1150        
Leu Ser Gln Lys Gln Arg Lys Met Ile Ala Leu Thr Thr Lys Glu Asn
        1155                1160                1165            
Asn Ser Gly Met Asn Ser Met Glu Thr Val Leu Phe Thr Pro Ser Lys
    1170                1175                1180                
Ala Pro Lys Pro Val Asn Ala
1185                1190    


<210> 2064
<211> 396
<212> PRT
<213> Homo sapiens

<400> 2064
Met Val Asp Phe Ala Met Asp Val Tyr Lys Asn Leu Tyr Ser Asp Asp
 1               5                  10                  15      
Ile Pro His Ala Leu Arg Glu Lys Arg Thr Thr Val Val Ala Gln Leu
            20                  25                  30          
Lys Gln Leu Gln Ala Glu Thr Glu Pro Ile Val Lys Met Phe Glu Asp
        35                  40                  45              
Pro Glu Thr Thr Arg Gln Met Gln Ser Thr Arg Asp Gly Arg Met Leu
    50                  55                  60                  
Phe Asp Tyr Leu Ala Asp Lys His Gly Phe Arg Gln Glu Tyr Leu Asp
65                  70                  75                  80  
Thr Leu Tyr Arg Tyr Ala Lys Phe Gln Tyr Glu Cys Gly Asn Tyr Ser
                85                  90                  95      
Gly Ala Ala Glu Tyr Leu Tyr Phe Phe Arg Val Leu Val Pro Ala Thr
            100                 105                 110         
Asp Arg Asn Ala Leu Ser Ser Leu Trp Gly Lys Leu Ala Ser Glu Ile
        115                 120                 125             
Leu Met Gln Asn Trp Asp Ala Ala Met Glu Asp Leu Thr Arg Leu Lys
    130                 135                 140                 
Glu Thr Ile Asp Asn Asn Ser Val Ser Ser Pro Leu Gln Ser Leu Gln
145                 150                 155                 160 
Gln Arg Thr Trp Leu Ile His Trp Ser Leu Phe Val Phe Phe Asn His
                165                 170                 175     
Pro Lys Gly Arg Asp Asn Ile Ile Asp Leu Phe Leu Tyr Gln Pro Gln
            180                 185                 190         
Tyr Leu Asn Ala Ile Gln Thr Met Cys Pro His Ile Leu Arg Tyr Leu
        195                 200                 205             
Thr Thr Ala Val Ile Thr Asn Lys Asp Val Arg Lys Arg Arg Gln Val
    210                 215                 220                 
Leu Lys Asp Leu Val Lys Val Ile Gln Gln Glu Ser Tyr Thr Tyr Lys
225                 230                 235                 240 
Asp Pro Ile Thr Glu Phe Val Glu Cys Leu Tyr Val Asn Phe Asp Phe
                245                 250                 255     
Asp Gly Ala Gln Lys Lys Leu Arg Glu Cys Glu Ser Val Leu Val Asn
            260                 265                 270         
Asp Phe Phe Leu Val Ala Cys Leu Glu Asp Phe Ile Glu Asn Ala Arg
        275                 280                 285             
Leu Phe Ile Phe Glu Thr Phe Cys Arg Ile His Gln Cys Ile Ser Ile
    290                 295                 300                 
Asn Met Leu Ala Asp Lys Leu Asn Met Thr Pro Glu Glu Ala Glu Arg
305                 310                 315                 320 
Trp Ile Val Asn Leu Ile Arg Asn Ala Arg Leu Asp Ala Lys Ile Asp
                325                 330                 335     
Ser Lys Leu Gly His Val Val Met Gly Asn Asn Ala Val Ser Pro Tyr
            340                 345                 350         
Gln Gln Val Ile Glu Lys Thr Lys Ser Leu Ser Phe Arg Ser Gln Met
        355                 360                 365             
Leu Ala Met Asn Ile Glu Lys Lys Leu Asn Gln Asn Ser Arg Ser Glu
    370                 375                 380                 
Ala Pro Asn Trp Ala Thr Gln Asp Ser Gly Phe Tyr
385                 390                 395     


<210> 2065
<211> 403
<212> PRT
<213> Homo sapiens

<400> 2065
Met Val Cys Pro Pro Gly Glu Val Pro Val Phe Trp Pro Ser Pro Leu
 1               5                  10                  15      
Thr Ser Leu Gly Ala Val Ser Ser Cys Glu Thr Pro Leu Ala Phe Ala
            20                  25                  30          
Ser Ile Pro Gly Cys Thr Val Met Thr Asp Leu Lys Asp Ala Lys Ala
        35                  40                  45              
Pro Pro Gly Cys Leu Thr Pro Glu Arg Ile Pro Glu Val His His Ile
    50                  55                  60                  
Ser Gln Asp Pro Leu His Tyr Ser Ile Ala Ser Val Ser Ala Ser Gln
65                  70                  75                  80  
Lys Ile Arg Glu Leu Glu Ser Met Ile Gly Ile Asp Pro Gly Asn Arg
                85                  90                  95      
Gly Ile Gly His Leu Leu Cys Lys Asp Glu Leu Leu Lys Ala Ser Leu
            100                 105                 110         
Ser Leu Ser His Ala Arg Ser Val Leu Ile Thr Thr Gly Phe Pro Thr
        115                 120                 125             
His Phe Asn His Glu Pro Pro Glu Glu Thr Asp Gly Pro Pro Gly Ala
    130                 135                 140                 
Val Ala Leu Val Ala Phe Leu Gln Ala Leu Glu Lys Glu Val Ala Ile
145                 150                 155                 160 
Ile Val Asp Gln Arg Ala Trp Asn Leu His Gln Lys Ile Val Glu Asp
                165                 170                 175     
Ala Val Glu Gln Gly Val Leu Lys Thr Gln Ile Pro Ile Leu Thr Tyr
            180                 185                 190         
Gln Gly Gly Ser Val Glu Ala Ala Gln Ala Phe Leu Cys Lys Asn Gly
        195                 200                 205             
Asp Pro Gln Thr Pro Arg Phe Asp His Leu Val Ala Ile Glu Arg Ala
    210                 215                 220                 
Gly Arg Ala Ala Asp Gly Asn Tyr Tyr Asn Ala Arg Lys Met Asn Ile
225                 230                 235                 240 
Lys His Leu Val Asp Pro Ile Asp Asp Leu Phe Leu Ala Ala Lys Lys
                245                 250                 255     
Ile Pro Gly Ile Ser Ser Thr Gly Val Gly Asp Gly Gly Asn Glu Leu
            260                 265                 270         
Gly Met Gly Lys Val Lys Glu Ala Val Arg Arg His Ile Arg His Gly
        275                 280                 285             
Asp Val Ile Ala Cys Asp Val Glu Ala Asp Phe Ala Val Ile Ala Gly
    290                 295                 300                 
Val Ser Asn Trp Gly Gly Tyr Ala Leu Ala Cys Ala Leu Tyr Ile Leu
305                 310                 315                 320 
Tyr Ser Cys Ala Val His Ser Gln Tyr Leu Arg Lys Ala Val Gly Pro
                325                 330                 335     
Ser Arg Ala Pro Gly Asp Gln Ala Trp Thr Gln Ala Leu Pro Ser Val
            340                 345                 350         
Ile Lys Glu Glu Lys Met Leu Gly Ile Leu Val Gln His Lys Val Arg
        355                 360                 365             
Ser Gly Val Ser Gly Ile Val Gly Met Glu Val Asp Gly Leu Pro Phe
    370                 375                 380                 
His Asn Thr His Ala Glu Met Ile Gln Lys Leu Val Asp Val Thr Thr
385                 390                 395                 400 
Ala Gln Val
            


<210> 2066
<211> 1935
<212> PRT
<213> Homo sapiens

<400> 2066
Met Glu Ala Arg Ala Ile Val Arg Gln Ala Met Ala Ile Leu Thr Pro
 1               5                  10                  15      
Ala Val Pro Ala Arg Met Glu Asp Gly His Gln Met Leu Thr His Trp
            20                  25                  30          
Thr Arg Lys Ile Ile Val Glu Glu Gly His Thr Val Pro Gln Leu Val
        35                  40                  45              
His Ile Leu His Leu Ile Val Gln His Phe Lys Val Tyr Tyr Pro Val
    50                  55                  60                  
Arg His His Leu Val Gln His Met Val Ser Ala Met Gln Arg Leu Gly
65                  70                  75                  80  
Phe Thr Pro Ser Val Thr Ile Glu Gln Arg Arg Leu Ala Val Asp Leu
                85                  90                  95      
Ser Glu Val Val Ile Lys Trp Glu Leu Gln Arg Ile Lys Asp Gln Gln
            100                 105                 110         
Pro Asp Ser Asp Met Asp Pro Asn Ser Ser Gly Glu Gly Val Asn Ser
        115                 120                 125             
Val Ser Ser Ser Ile Lys Arg Gly Leu Ser Val Asp Ser Ala Gln Glu
    130                 135                 140                 
Val Lys Arg Phe Arg Thr Ala Thr Gly Ala Ile Ser Ala Val Phe Gly
145                 150                 155                 160 
Arg Ser Gln Ser Leu Pro Gly Ala Asp Ser Leu Leu Ala Lys Pro Ile
                165                 170                 175     
Asp Lys Gln His Thr Asp Thr Val Val Asn Phe Leu Ile Arg Val Ala
            180                 185                 190         
Cys Gln Val Asn Asp Asn Thr Asn Thr Ala Gly Ser Pro Gly Glu Val
        195                 200                 205             
Leu Ser Arg Arg Cys Val Asn Leu Leu Lys Thr Ala Leu Arg Pro Asp
    210                 215                 220                 
Met Trp Pro Lys Ser Glu Leu Lys Leu Gln Trp Phe Asp Lys Leu Leu
225                 230                 235                 240 
Met Thr Val Glu Gln Pro Asn Gln Val Asn Tyr Gly Asn Ile Cys Thr
                245                 250                 255     
Gly Leu Glu Val Leu Ser Phe Leu Leu Thr Val Leu Gln Ser Pro Ala
            260                 265                 270         
Ile Leu Ser Ser Phe Lys Pro Leu Gln Arg Gly Ile Ala Ala Cys Met
        275                 280                 285             
Thr Cys Gly Asn Thr Lys Val Leu Arg Ala Val His Ser Leu Leu Ser
    290                 295                 300                 
Arg Leu Met Ser Ile Phe Pro Thr Glu Pro Ser Thr Ser Ser Val Ala
305                 310                 315                 320 
Ser Lys Tyr Glu Glu Leu Glu Cys Leu Tyr Ala Ala Val Gly Lys Val
                325                 330                 335     
Ile Tyr Glu Gly Leu Thr Asn Tyr Glu Lys Ala Thr Asn Ala Asn Pro
            340                 345                 350         
Ser Gln Leu Phe Gly Thr Leu Met Ile Leu Lys Ser Ala Cys Ser Asn
        355                 360                 365             
Asn Pro Ser Tyr Ile Asp Arg Leu Ile Ser Val Phe Met Arg Ser Leu
    370                 375                 380                 
Gln Lys Met Val Arg Glu His Leu Asn Pro Gln Ala Ala Ser Gly Ser
385                 390                 395                 400 
Thr Glu Ala Thr Ser Gly Thr Ser Glu Leu Val Met Leu Ser Leu Glu
                405                 410                 415     
Leu Val Lys Thr Arg Leu Ala Val Met Ser Met Glu Met Arg Lys Asn
            420                 425                 430         
Phe Ile Gln Ala Ile Leu Thr Ser Leu Ile Glu Lys Ser Pro Asp Ala
        435                 440                 445             
Lys Ile Leu Arg Ala Val Val Lys Ile Val Glu Glu Trp Val Lys Asn
    450                 455                 460                 
Asn Ser Pro Met Ala Ala Asn Gln Thr Pro Thr Leu Arg Glu Lys Ser
465                 470                 475                 480 
Ile Leu Leu Val Lys Met Met Thr Tyr Ile Glu Lys Arg Phe Pro Glu
                485                 490                 495     
Asp Leu Glu Leu Asn Ala Gln Phe Leu Asp Leu Val Asn Tyr Val Tyr
            500                 505                 510         
Arg Asp Glu Thr Leu Ser Gly Ser Glu Leu Thr Ala Lys Leu Glu Pro
        515                 520                 525             
Ala Phe Leu Ser Gly Leu Arg Cys Ala Gln Pro Leu Ile Arg Ala Lys
    530                 535                 540                 
Phe Phe Glu Val Phe Asp Asn Ser Met Lys Arg Arg Val Tyr Glu Arg
545                 550                 555                 560 
Leu Leu Tyr Val Thr Cys Ser Gln Asn Trp Glu Ala Met Gly Asn His
                565                 570                 575     
Phe Trp Ile Lys Gln Cys Ile Glu Leu Leu Leu Ala Val Cys Glu Lys
            580                 585                 590         
Ser Thr Pro Ile Gly Thr Ser Cys Gln Gly Ala Met Leu Pro Ser Ile
        595                 600                 605             
Thr Asn Val Ile Asn Leu Ala Asp Ser His Asp Arg Ala Ala Phe Ala
    610                 615                 620                 
Met Val Thr His Val Lys Gln Glu Pro Arg Glu Arg Glu Asn Ser Glu
625                 630                 635                 640 
Ser Lys Glu Glu Asp Val Glu Ile Asp Ile Glu Leu Ala Pro Gly Asp
                645                 650                 655     
Gln Thr Ser Thr Pro Lys Thr Lys Glu Leu Ser Glu Lys Asp Ile Gly
            660                 665                 670         
Asn Gln Leu His Met Leu Thr Asn Arg His Asp Lys Phe Leu Asp Thr
        675                 680                 685             
Leu Arg Glu Val Lys Thr Gly Ala Leu Leu Ser Ala Phe Val Gln Leu
    690                 695                 700                 
Cys His Ile Ser Thr Thr Leu Ala Glu Lys Thr Trp Val Gln Leu Phe
705                 710                 715                 720 
Pro Arg Leu Trp Lys Ile Leu Ser Asp Arg Gln Gln His Ala Leu Ala
                725                 730                 735     
Gly Glu Ile Ser Pro Phe Leu Cys Ser Gly Ser His Gln Val Gln Arg
            740                 745                 750         
Asp Cys Gln Pro Ser Ala Leu Asn Cys Phe Val Glu Ala Met Ser Gln
        755                 760                 765             
Cys Val Pro Pro Ile Pro Ile Arg Pro Cys Val Leu Lys Tyr Leu Gly
    770                 775                 780                 
Lys Thr His Asn Leu Trp Phe Arg Ser Thr Leu Met Leu Glu His Gln
785                 790                 795                 800 
Ala Phe Glu Lys Gly Leu Ser Leu Gln Ile Lys Pro Lys Gln Thr Thr
                805                 810                 815     
Glu Phe Tyr Glu Gln Glu Ser Ile Thr Pro Pro Gln Gln Glu Ile Leu
            820                 825                 830         
Asp Ser Leu Ala Glu Leu Tyr Ser Leu Leu Gln Glu Glu Asp Met Trp
        835                 840                 845             
Ala Gly Leu Trp Gln Lys Arg Cys Lys Tyr Ser Glu Thr Ala Thr Ala
    850                 855                 860                 
Ile Ala Tyr Glu Gln His Gly Phe Phe Glu Gln Ala Gln Glu Ser Tyr
865                 870                 875                 880 
Glu Lys Ala Met Asp Lys Ala Lys Lys Glu His Glu Arg Ser Asn Ala
                885                 890                 895     
Ser Pro Ala Ile Phe Pro Glu Tyr Gln Leu Trp Glu Asp His Trp Ile
            900                 905                 910         
Arg Cys Ser Lys Glu Leu Asn Gln Trp Glu Ala Leu Thr Glu Tyr Gly
        915                 920                 925             
Gln Ser Lys Gly His Ile Asn Pro Tyr Leu Val Leu Glu Cys Ala Trp
    930                 935                 940                 
Arg Val Ser Asn Trp Thr Ala Met Lys Glu Ala Leu Val Gln Val Glu
945                 950                 955                 960 
Val Ser Cys Pro Lys Glu Met Ala Trp Lys Val Asn Met Tyr Arg Gly
                965                 970                 975     
Tyr Leu Ala Ile Cys His Pro Glu Glu Gln Gln Leu Ser Phe Ile Glu
            980                 985                 990         
Arg Leu Val Glu Met Ala Ser Ser Leu Ala Ile Arg Glu Trp Arg Arg
        995                 1000                1005            
Leu Pro His Val Val Ser His Val His Thr Pro Leu Leu Gln Ala Ala
    1010                1015                1020                
Gln Gln Ile Ile Glu Leu Gln Glu Ala Ala Gln Ile Asn Ala Gly Leu
1025                1030                1035                1040
Gln Pro Thr Asn Leu Gly Arg Asn Asn Ser Leu His Asp Met Lys Thr
                1045                1050                1055    
Val Val Lys Thr Trp Arg Asn Arg Leu Pro Ile Val Ser Asp Asp Leu
            1060                1065                1070        
Ser His Trp Ser Ser Ile Phe Met Trp Arg Gln His His Tyr Gln Ala
        1075                1080                1085            
Ile Val Thr Ala Tyr Glu Asn Ser Ser Gln His Asp Pro Ser Ser Asn
    1090                1095                1100                
Asn Ala Met Leu Gly Val His Ala Ser Ala Ser Ala Ile Ile Gln Tyr
1105                1110                1115                1120
Gly Lys Ile Ala Arg Lys Gln Gly Leu Val Asn Val Ala Leu Asp Ile
                1125                1130                1135    
Leu Ser Arg Ile His Thr Ile Pro Thr Val Pro Ile Val Asp Cys Phe
            1140                1145                1150        
Gln Lys Ile Arg Gln Gln Val Lys Cys Tyr Leu Gln Leu Ala Gly Val
        1155                1160                1165            
Met Gly Lys Asn Glu Cys Met Gln Gly Leu Glu Val Ile Glu Ser Thr
    1170                1175                1180                
Asn Leu Lys Tyr Phe Thr Lys Glu Met Thr Ala Glu Phe Tyr Ala Leu
1185                1190                1195                1200
Lys Gly Met Phe Leu Ala Gln Ile Asn Lys Ser Glu Glu Ala Asn Lys
                1205                1210                1215    
Ala Phe Ser Ala Ala Val Gln Met His Asp Val Leu Val Lys Ala Trp
            1220                1225                1230        
Ala Met Trp Gly Asp Tyr Leu Glu Asn Ile Phe Val Lys Glu Arg Gln
        1235                1240                1245            
Leu His Leu Gly Val Ser Ala Ile Thr Cys Tyr Leu His Ala Cys Arg
    1250                1255                1260                
His Gln Asn Glu Ser Lys Ser Arg Lys Tyr Leu Ala Lys Val Leu Trp
1265                1270                1275                1280
Leu Leu Ser Phe Asp Asp Asp Lys Asn Thr Leu Ala Asp Ala Val Asp
                1285                1290                1295    
Lys Tyr Cys Ile Gly Val Pro Pro Ile Gln Trp Leu Ala Trp Ile Pro
            1300                1305                1310        
Gln Leu Leu Thr Cys Leu Val Gly Ser Glu Gly Lys Leu Leu Leu Asn
        1315                1320                1325            
Leu Ile Ser Gln Val Gly Arg Val Tyr Pro Gln Ala Val Tyr Phe Pro
    1330                1335                1340                
Ile Arg Thr Leu Tyr Leu Thr Leu Lys Ile Glu Gln Arg Glu Arg Tyr
1345                1350                1355                1360
Lys Ser Asp Pro Gly Pro Ile Arg Ala Thr Ala Pro Met Trp Arg Cys
                1365                1370                1375    
Ser Arg Ile Met His Met Gln Arg Glu Leu His Pro Thr Leu Leu Ser
            1380                1385                1390        
Ser Leu Glu Gly Ile Val Asp Gln Met Val Trp Phe Arg Glu Asn Trp
        1395                1400                1405            
His Glu Glu Val Leu Arg Gln Leu Gln Gln Gly Leu Ala Lys Cys Tyr
    1410                1415                1420                
Ser Val Ala Phe Glu Lys Ser Gly Ala Val Ser Asp Ala Lys Ile Thr
1425                1430                1435                1440
Pro His Thr Leu Asn Phe Val Lys Lys Leu Val Ser Thr Phe Gly Val
                1445                1450                1455    
Gly Leu Glu Asn Val Ser Asn Val Ser Thr Met Phe Ser Ser Ala Ala
            1460                1465                1470        
Ser Glu Ser Leu Ala Arg Arg Ala Gln Ala Thr Ala Gln Asp Pro Val
        1475                1480                1485            
Phe Gln Lys Leu Lys Gly Gln Phe Thr Thr Asp Phe Asp Phe Ser Val
    1490                1495                1500                
Pro Gly Ser Met Lys Leu His Asn Leu Ile Ser Lys Leu Lys Lys Trp
1505                1510                1515                1520
Ile Lys Ile Leu Glu Ala Lys Thr Lys Gln Leu Pro Lys Phe Phe Leu
                1525                1530                1535    
Ile Glu Glu Lys Cys Arg Phe Leu Ser Asn Phe Ser Ala Gln Thr Ala
            1540                1545                1550        
Glu Val Glu Ile Pro Gly Glu Phe Leu Met Pro Lys Pro Thr His Tyr
        1555                1560                1565            
Tyr Ile Lys Ile Ala Arg Phe Met Pro Arg Val Glu Ile Val Gln Lys
    1570                1575                1580                
His Asn Thr Ala Ala Arg Arg Leu Tyr Ile Arg Gly His Asn Gly Lys
1585                1590                1595                1600
Ile Tyr Pro Tyr Leu Val Met Asn Asp Ala Cys Leu Thr Glu Ser Arg
                1605                1610                1615    
Arg Glu Glu Arg Val Leu Gln Leu Leu Arg Leu Leu Asn Pro Cys Leu
            1620                1625                1630        
Glu Lys Arg Lys Glu Thr Thr Lys Arg His Leu Phe Phe Thr Val Pro
        1635                1640                1645            
Arg Val Val Ala Val Ser Pro Gln Met Arg Leu Val Glu Asp Asn Pro
    1650                1655                1660                
Ser Ser Leu Ser Leu Val Glu Ile Tyr Lys Gln Arg Cys Ala Lys Lys
1665                1670                1675                1680
Gly Ile Glu His Asp Asn Pro Ile Ser Arg Tyr Tyr Asp Arg Leu Ala
                1685                1690                1695    
Thr Val Gln Ala Arg Gly Thr Gln Ala Ser His Gln Val Leu Arg Asp
            1700                1705                1710        
Ile Leu Lys Glu Val Gln Ser Asn Met Val Pro Arg Ser Met Leu Lys
        1715                1720                1725            
Glu Trp Ala Leu His Thr Phe Pro Asn Ala Thr Asp Tyr Trp Thr Phe
    1730                1735                1740                
Arg Lys Met Phe Thr Ile Gln Leu Ala Leu Ile Gly Phe Ala Glu Phe
1745                1750                1755                1760
Val Leu His Leu Asn Arg Leu Asn Pro Glu Met Leu Gln Ile Ala Gln
                1765                1770                1775    
Asp Thr Gly Lys Leu Asn Val Ala Tyr Phe Arg Phe Asp Ile Asn Asp
            1780                1785                1790        
Ala Thr Gly Asp Leu Asp Ala Asn Arg Pro Val Pro Phe Arg Leu Thr
        1795                1800                1805            
Pro Asn Ile Ser Glu Phe Leu Thr Thr Ile Gly Val Ser Gly Pro Leu
    1810                1815                1820                
Thr Ala Ser Met Ile Ala Val Ala Arg Cys Phe Ala Gln Pro Asn Phe
1825                1830                1835                1840
Lys Val Asp Gly Ile Leu Lys Thr Val Leu Arg Asp Glu Ile Ile Ala
                1845                1850                1855    
Trp His Lys Lys Thr Gln Glu Asp Thr Ser Ser Pro Leu Ser Ala Ala
            1860                1865                1870        
Gly Gln Pro Glu Asn Met Asp Ser Gln Gln Leu Val Ser Leu Val Gln
        1875                1880                1885            
Lys Ala Val Thr Ala Ile Met Thr Arg Leu His Asn Leu Ala Gln Phe
    1890                1895                1900                
Glu Gly Gly Glu Ser Lys Val Asn Thr Leu Val Ala Ala Ala Asn Ser
1905                1910                1915                1920
Leu Asp Asn Leu Cys Arg Met Asp Pro Ala Trp His Pro Trp Leu
                1925                1930                1935


<210> 2067
<211> 973
<212> PRT
<213> Homo sapiens

<400> 2067
Met Ala Ser Ile Leu Asp Glu Tyr Glu Asn Ser Leu Ser Arg Ser Ala
 1               5                  10                  15      
Val Leu Gln Pro Gly Cys Pro Ser Val Gly Ile Pro His Ser Gly Tyr
            20                  25                  30          
Val Asn Ala Gln Leu Glu Lys Glu Val Pro Ile Phe Thr Lys Gln Arg
        35                  40                  45              
Ile Asp Phe Thr Pro Ser Glu Arg Ile Thr Ser Leu Val Val Ser Ser
    50                  55                  60                  
Asn Gln Leu Cys Met Ser Leu Gly Lys Asp Thr Leu Leu Arg Ile Asp
65                  70                  75                  80  
Leu Gly Lys Ala Asn Glu Pro Asn His Val Glu Leu Gly Arg Lys Asp
                85                  90                  95      
Asp Ala Lys Val His Lys Met Phe Leu Asp His Thr Gly Ser His Leu
            100                 105                 110         
Leu Ile Ala Leu Ser Ser Thr Glu Val Leu Tyr Val Asn Arg Asn Gly
        115                 120                 125             
Gln Lys Val Arg Pro Leu Ala Arg Trp Lys Gly Gln Leu Val Glu Ser
    130                 135                 140                 
Val Gly Trp Asn Lys Ala Leu Gly Thr Glu Ser Ser Thr Gly Pro Ile
145                 150                 155                 160 
Leu Val Gly Thr Ala Gln Gly His Ile Phe Glu Ala Glu Leu Ser Ala
                165                 170                 175     
Ser Glu Gly Gly Leu Phe Gly Pro Ala Pro Asp Leu Tyr Phe Arg Pro
            180                 185                 190         
Leu Tyr Val Leu Asn Glu Glu Gly Gly Pro Ala Pro Val Cys Ser Leu
        195                 200                 205             
Glu Ala Glu Arg Gly Pro Asp Gly Arg Ser Phe Val Ile Ala Thr Thr
    210                 215                 220                 
Arg Gln Arg Leu Phe Gln Phe Ile Gly Arg Ala Ala Glu Gly Ala Glu
225                 230                 235                 240 
Ala Gln Gly Phe Ser Gly Leu Phe Ala Ala Tyr Thr Asp His Pro Pro
                245                 250                 255     
Pro Phe Arg Glu Phe Pro Ser Asn Leu Gly Tyr Ser Glu Leu Ala Phe
            260                 265                 270         
Tyr Thr Pro Lys Leu Arg Ser Ala Pro Arg Ala Phe Ala Trp Met Met
        275                 280                 285             
Gly Asp Gly Val Leu Tyr Gly Ala Leu Asp Cys Gly Arg Pro Asp Ser
    290                 295                 300                 
Leu Leu Ser Glu Glu Arg Val Trp Glu Tyr Pro Glu Gly Val Gly Pro
305                 310                 315                 320 
Gly Ala Ser Pro Pro Leu Ala Ile Val Leu Thr Gln Phe His Phe Leu
                325                 330                 335     
Leu Leu Leu Ala Asp Arg Val Glu Ala Val Cys Thr Leu Thr Gly Gln
            340                 345                 350         
Val Val Leu Arg Asp His Phe Leu Glu Lys Phe Gly Pro Leu Lys His
        355                 360                 365             
Met Val Lys Asp Ser Ser Thr Gly Gln Leu Trp Ala Tyr Thr Glu Arg
    370                 375                 380                 
Ala Val Phe Arg Tyr His Val Gln Arg Glu Ala Arg Asp Val Trp Arg
385                 390                 395                 400 
Thr Tyr Leu Asp Met Asn Arg Phe Asp Leu Ala Lys Glu Tyr Cys Arg
                405                 410                 415     
Glu Arg Pro Asp Cys Leu Asp Thr Val Leu Ala Arg Glu Ala Asp Phe
            420                 425                 430         
Cys Phe Arg Gln Arg Arg Tyr Leu Glu Ser Ala Arg Cys Tyr Ala Leu
        435                 440                 445             
Thr Gln Ser Tyr Phe Glu Glu Ile Ala Leu Lys Phe Leu Glu Ala Arg
    450                 455                 460                 
Gln Glu Glu Ala Leu Ala Glu Phe Leu Gln Arg Lys Leu Ala Ser Leu
465                 470                 475                 480 
Lys Pro Ala Glu Arg Thr Gln Ala Thr Leu Leu Thr Thr Trp Leu Thr
                485                 490                 495     
Glu Leu Tyr Leu Ser Arg Leu Gly Ala Leu Gln Gly Asp Pro Glu Ala
            500                 505                 510         
Leu Thr Leu Tyr Arg Glu Thr Lys Glu Cys Phe Arg Thr Phe Leu Ser
        515                 520                 525             
Ser Pro Arg His Lys Glu Trp Leu Phe Ala Ser Arg Ala Ser Ile His
    530                 535                 540                 
Glu Leu Leu Ala Ser His Gly Asp Thr Glu His Met Val Tyr Phe Ala
545                 550                 555                 560 
Val Ile Met Gln Asp Tyr Glu Arg Val Val Ala Tyr His Cys Gln His
                565                 570                 575     
Glu Ala Tyr Glu Glu Ala Leu Ala Val Leu Ala Arg His Arg Asp Pro
            580                 585                 590         
Gln Leu Phe Tyr Lys Phe Ser Pro Ile Leu Ile Arg His Ile Pro Arg
        595                 600                 605             
Gln Leu Val Asp Ala Trp Ile Glu Met Gly Ser Arg Leu Asp Ala Arg
    610                 615                 620                 
Gln Leu Ile Pro Ala Leu Val Asn Tyr Ser Gln Gly Gly Glu Val Gln
625                 630                 635                 640 
Gln Val Ser Gln Ala Ile Arg Tyr Met Glu Phe Cys Val Asn Val Leu
                645                 650                 655     
Gly Glu Thr Glu Gln Ala Ile His Asn Tyr Leu Leu Ser Leu Tyr Ala
            660                 665                 670         
Arg Gly Arg Pro Asp Ser Leu Leu Ala Tyr Leu Glu Gln Ala Gly Ala
        675                 680                 685             
Ser Pro His Arg Val His Tyr Asp Leu Lys Tyr Ala Leu Arg Leu Cys
    690                 695                 700                 
Ala Glu His Gly His His Arg Ala Cys Val His Val Tyr Lys Val Leu
705                 710                 715                 720 
Glu Leu Tyr Glu Glu Ala Val Asp Leu Ala Leu Gln Val Asp Val Asp
                725                 730                 735     
Leu Ala Lys Gln Cys Ala Asp Leu Pro Glu Glu Asp Glu Glu Leu Arg
            740                 745                 750         
Lys Lys Leu Trp Leu Lys Ile Ala Arg His Val Val Gln Glu Glu Glu
        755                 760                 765             
Asp Val Gln Thr Ala Met Ala Cys Leu Ala Ser Cys Pro Leu Leu Lys
    770                 775                 780                 
Ile Glu Asp Val Leu Pro Phe Phe Pro Asp Phe Val Thr Ile Asp His
785                 790                 795                 800 
Phe Lys Glu Ala Ile Cys Ser Ser Leu Lys Ala Tyr Asn His His Ile
                805                 810                 815     
Gln Glu Leu Gln Arg Glu Met Glu Glu Ala Thr Ala Ser Ala Gln Arg
            820                 825                 830         
Ile Arg Arg Asp Leu Gln Glu Leu Arg Gly Arg Tyr Gly Thr Val Glu
        835                 840                 845             
Pro Gln Asp Lys Cys Ala Thr Cys Asp Phe Pro Leu Leu Asn Arg Pro
    850                 855                 860                 
Phe Tyr Leu Phe Leu Cys Gly His Met Phe His Ala Asp Cys Leu Leu
865                 870                 875                 880 
Gln Ala Val Arg Pro Gly Leu Pro Ala Tyr Lys Gln Ala Arg Leu Glu
                885                 890                 895     
Glu Leu Gln Arg Lys Leu Gly Ala Ala Pro Pro Pro Ala Lys Gly Ser
            900                 905                 910         
Ala Arg Ala Lys Glu Ala Glu Gly Gly Ala Ala Thr Ala Gly Pro Ser
        915                 920                 925             
Arg Glu Gln Leu Lys Ala Asp Leu Asp Glu Leu Val Ala Ala Glu Cys
    930                 935                 940                 
Val Tyr Cys Gly Glu Leu Met Ile Arg Ser Ile Asp Arg Pro Phe Ile
945                 950                 955                 960 
Asp Pro Gln Arg Tyr Glu Glu Glu Gln Leu Ser Trp Leu
                965                 970             


<210> 2068
<211> 1833
<212> PRT
<213> Homo sapiens

<400> 2068
Met Asp Gly Val Ser Ser Glu Ala Asn Glu Glu Asn Asp Asn Ile Glu
 1               5                  10                  15      
Arg Pro Val Arg Arg Arg His Ser Ser Ile Leu Lys Pro Pro Arg Ser
            20                  25                  30          
Pro Leu Gln Asp Leu Arg Gly Gly Asn Glu Arg Val Gln Glu Ser Asn
        35                  40                  45              
Ala Leu Arg Asn Lys Lys Asn Ser Arg Arg Val Ser Phe Ala Asp Thr
    50                  55                  60                  
Ile Lys Val Phe Gln Thr Glu Ser His Met Lys Ile Val Arg Lys Ser
65                  70                  75                  80  
Glu Met Glu Glu Thr Glu Thr Gly Glu Asn Leu Leu Leu Ile Gln Asn
                85                  90                  95      
Lys Lys Leu Glu Asp Asn Tyr Cys Glu Ile Thr Gly Met Asn Thr Leu
            100                 105                 110         
Leu Ser Ala Pro Ile His Thr Gln Met Gln Gln Lys Glu Phe Ser Ile
        115                 120                 125             
Ile Glu His Thr Arg Glu Arg Lys His Ala Asn Asp Gln Thr Val Ile
    130                 135                 140                 
Phe Ser Asp Glu Asn Gln Met Asp Leu Thr Ser Ser His Thr Val Met
145                 150                 155                 160 
Ile Thr Lys Gly Leu Leu Asp Asn Pro Ile Ser Glu Lys Ser Thr Lys
                165                 170                 175     
Ile Asp Thr Thr Ser Phe Leu Ala Asn Leu Lys Leu His Thr Glu Asp
            180                 185                 190         
Ser Arg Met Lys Lys Glu Val Asn Phe Ser Val Asp Gln Asn Thr Ser
        195                 200                 205             
Ser Glu Asn Lys Ile Asp Phe Asn Asp Phe Ile Lys Arg Leu Lys Thr
    210                 215                 220                 
Gly Lys Cys Ser Ala Phe Pro Asp Val Pro Asp Lys Glu Asn Phe Glu
225                 230                 235                 240 
Ile Pro Ile Tyr Ser Lys Glu Pro Asn Ser Ala Ser Ser Thr His Gln
                245                 250                 255     
Met His Val Ser Leu Lys Glu Asp Glu Asn Asn Ser Asn Ile Thr Arg
            260                 265                 270         
Leu Phe Arg Glu Lys Asp Asp Gly Met Asn Phe Thr Gln Cys His Thr
        275                 280                 285             
Ala Asn Ile Gln Thr Leu Ile Pro Thr Ser Ser Glu Thr Asn Ser Arg
    290                 295                 300                 
Glu Ser Lys Gly Asn Asp Ile Thr Ile Tyr Gly Asn Asp Phe Met Asp
305                 310                 315                 320 
Leu Thr Phe Asn His Thr Leu Gln Ile Leu Pro Ala Thr Gly Asn Phe
                325                 330                 335     
Ser Glu Ile Glu Asn Gln Thr Gln Asn Ala Met Asp Val Thr Thr Gly
            340                 345                 350         
Tyr Gly Thr Lys Ala Ser Gly Asn Lys Thr Val Phe Lys Ser Lys Gln
        355                 360                 365             
Asn Thr Ala Phe Gln Asp Leu Ser Ile Asn Ser Ala Asp Lys Ile His
    370                 375                 380                 
Ile Thr Arg Ser His Ile Met Gly Ala Glu Thr His Ile Val Ser Gln
385                 390                 395                 400 
Thr Cys Asn Gln Asp Ala Arg Ile Leu Ala Met Thr Pro Glu Ser Ile
                405                 410                 415     
Tyr Ser Asn Pro Ser Ile Gln Gly Cys Lys Thr Val Phe Tyr Ser Ser
            420                 425                 430         
Cys Asn Asp Ala Met Glu Met Thr Lys Cys Leu Ser Asn Met Arg Glu
        435                 440                 445             
Glu Lys Asn Leu Leu Lys His Asp Ser Asn Tyr Ala Lys Met Tyr Cys
    450                 455                 460                 
Asn Pro Asp Ala Met Ser Ser Leu Thr Glu Lys Thr Ile Tyr Ser Gly
465                 470                 475                 480 
Glu Glu Asn Met Asp Ile Thr Lys Ser His Thr Val Ala Ile Asp Asn
                485                 490                 495     
Gln Ile Phe Lys Gln Asp Gln Ser Asn Val Gln Ile Ala Ala Ala Pro
            500                 505                 510         
Thr Pro Glu Lys Glu Met Met Leu Gln Asn Leu Met Thr Thr Ser Glu
        515                 520                 525             
Asp Gly Lys Met Asn Val Asn Cys Asn Ser Val Pro His Val Ser Lys
    530                 535                 540                 
Glu Arg Ile Gln Gln Ser Leu Ser Asn Pro Leu Ser Ile Ser Leu Thr
545                 550                 555                 560 
Asp Arg Lys Thr Glu Leu Leu Ser Gly Glu Asn Met Asp Leu Thr Glu
                565                 570                 575     
Ser His Thr Ser Asn Leu Gly Ser Gln Val Pro Leu Ala Ala Tyr Asn
            580                 585                 590         
Leu Ala Pro Glu Ser Thr Ser Glu Ser His Ser Gln Ser Lys Ser Ser
        595                 600                 605             
Ser Asp Glu Cys Glu Glu Ile Thr Lys Ser Arg Asn Glu Pro Phe Gln
    610                 615                 620                 
Arg Ser Asp Ile Ile Ala Lys Asn Ser Leu Thr Asp Thr Trp Asn Lys
625                 630                 635                 640 
Asp Lys Asp Trp Val Leu Lys Ile Leu Pro Tyr Leu Asp Lys Asp Ser
                645                 650                 655     
Pro Gln Ser Ala Asp Cys Asn Gln Glu Ile Ala Thr Ser His Asn Ile
            660                 665                 670         
Val Tyr Cys Gly Gly Val Leu Asp Lys Gln Ile Thr Asn Arg Asn Thr
        675                 680                 685             
Val Ser Trp Glu Gln Ser Leu Phe Ser Thr Thr Lys Pro Leu Phe Ser
    690                 695                 700                 
Ser Gly Gln Phe Ser Met Lys Asn His Asp Thr Ala Ile Ser Ser His
705                 710                 715                 720 
Thr Val Lys Ser Val Leu Gly Gln Asn Ser Lys Leu Ala Glu Pro Leu
                725                 730                 735     
Arg Lys Ser Leu Ser Asn Pro Thr Pro Asp Tyr Cys His Asp Lys Met
            740                 745                 750         
Ile Ile Cys Ser Glu Glu Glu Gln Asn Met Asp Leu Thr Lys Ser His
        755                 760                 765             
Thr Val Val Ile Gly Phe Gly Pro Ser Glu Leu Gln Glu Leu Gly Lys
    770                 775                 780                 
Thr Asn Leu Glu His Thr Thr Gly Gln Leu Thr Thr Met Asn Arg Gln
785                 790                 795                 800 
Ile Ala Val Lys Val Glu Lys Cys Gly Lys Ser Pro Ile Glu Lys Ser
                805                 810                 815     
Gly Val Leu Lys Ser Asn Cys Ile Met Asp Val Leu Glu Asp Glu Ser
            820                 825                 830         
Val Gln Lys Pro Lys Phe Pro Lys Glu Lys Gln Asn Val Lys Ile Trp
        835                 840                 845             
Gly Arg Lys Ser Val Gly Gly Pro Lys Ile Asp Lys Thr Ile Val Phe
    850                 855                 860                 
Ser Glu Asp Asp Lys Asn Asp Met Asp Ile Thr Lys Ser Tyr Thr Ile
865                 870                 875                 880 
Glu Ile Asn His Arg Pro Leu Leu Glu Lys Arg Asp Cys His Leu Val
                885                 890                 895     
Pro Leu Ala Gly Thr Ser Glu Thr Ile Leu Tyr Thr Cys Arg Gln Asp
            900                 905                 910         
Asp Met Glu Ile Thr Arg Ser His Thr Thr Ala Leu Glu Cys Lys Thr
        915                 920                 925             
Val Ser Pro Asp Glu Ile Thr Thr Arg Pro Met Asp Lys Thr Val Val
    930                 935                 940                 
Phe Val Asp Asn His Val Glu Leu Glu Met Thr Glu Ser His Thr Val
945                 950                 955                 960 
Phe Ile Asp Tyr Gln Glu Lys Glu Arg Thr Asp Arg Pro Asn Phe Glu
                965                 970                 975     
Leu Ser Gln Arg Lys Ser Leu Gly Thr Pro Thr Val Ile Cys Thr Pro
            980                 985                 990         
Thr Glu Glu Ser Val Phe Phe Pro Gly Asn Gly Glu Ser Asp Arg Leu
        995                 1000                1005            
Val Ala Asn Asp Ser Gln Leu Thr Pro Leu Glu Glu Trp Ser Asn Asn
    1010                1015                1020                
Arg Gly Pro Val Glu Val Ala Asp Asn Met Glu Leu Ser Lys Ser Ala
1025                1030                1035                1040
Thr Cys Lys Asn Ile Lys Asp Val Gln Ser Pro Gly Phe Leu Asn Glu
                1045                1050                1055    
Pro Leu Ser Ser Lys Ser Gln Arg Arg Lys Ser Leu Lys Leu Lys Asn
            1060                1065                1070        
Asp Lys Thr Ile Val Phe Ser Glu Asn His Lys Asn Asp Met Asp Ile
        1075                1080                1085            
Thr Gln Ser Cys Met Val Glu Ile Asp Asn Glu Ser Ala Leu Glu Asp
    1090                1095                1100                
Lys Glu Asp Phe His Leu Ala Gly Ala Ser Lys Thr Ile Leu Tyr Ser
1105                1110                1115                1120
Cys Gly Gln Asp Asp Met Glu Ile Thr Arg Ser His Thr Thr Ala Leu
                1125                1130                1135    
Glu Cys Lys Thr Leu Leu Pro Asn Glu Ile Ala Ile Arg Pro Met Asp
            1140                1145                1150        
Lys Thr Val Leu Phe Thr Asp Asn Tyr Ser Asp Leu Glu Val Thr Asp
        1155                1160                1165            
Ser His Thr Val Phe Ile Asp Cys Gln Ala Thr Glu Lys Ile Leu Glu
    1170                1175                1180                
Glu Asn Pro Lys Phe Gly Ile Gly Lys Gly Lys Asn Leu Gly Val Ser
1185                1190                1195                1200
Phe Pro Lys Asp Asn Ser Cys Val Gln Glu Ile Ala Glu Lys Gln Ala
                1205                1210                1215    
Leu Ala Val Gly Asn Lys Ile Val Leu His Thr Glu Gln Lys Gln Gln
            1220                1225                1230        
Leu Phe Ala Ala Thr Asn Arg Thr Thr Asn Glu Ile Ile Lys Phe His
        1235                1240                1245            
Ser Ala Ala Met Asp Glu Lys Val Ile Gly Lys Val Val Asp Gln Ala
    1250                1255                1260                
Cys Thr Leu Glu Lys Ala Gln Val Glu Ser Cys Gln Leu Asn Asn Arg
1265                1270                1275                1280
Asp Arg Arg Asn Val Asp Phe Thr Ser Ser His Ala Thr Ala Val Cys
                1285                1290                1295    
Gly Ser Ser Asp Asn Tyr Ser Cys Leu Pro Asn Val Ile Ser Cys Thr
            1300                1305                1310        
Asp Asn Leu Glu Gly Ser Ala Met Leu Leu Cys Asp Lys Asp Glu Glu
        1315                1320                1325            
Lys Ala Asn Tyr Cys Pro Val Gln Asn Asp Leu Ala Tyr Ala Asn Asp
    1330                1335                1340                
Phe Ala Ser Glu Tyr Tyr Leu Glu Ser Glu Gly Gln Pro Leu Ser Ala
1345                1350                1355                1360
Pro Cys Pro Leu Leu Glu Lys Glu Glu Val Ile Gln Thr Ser Thr Lys
                1365                1370                1375    
Gly Gln Leu Asp Cys Val Ile Thr Leu His Lys Asp Gln Asp Leu Ile
            1380                1385                1390        
Lys Asp Pro Arg Asn Leu Leu Ala Asn Gln Thr Leu Val Tyr Ser Gln
        1395                1400                1405            
Asp Leu Gly Glu Met Thr Lys Leu Asn Ser Lys Arg Val Ser Phe Lys
    1410                1415                1420                
Leu Pro Lys Asp Gln Met Lys Val Tyr Val Asp Asp Ile Tyr Val Ile
1425                1430                1435                1440
Pro Gln Pro His Phe Ser Thr Asp Gln Pro Pro Leu Pro Lys Lys Gly
                1445                1450                1455    
Gln Ser Ser Ile Asn Lys Glu Glu Val Ile Leu Ser Lys Ala Gly Asn
            1460                1465                1470        
Lys Ser Leu Asn Ile Ile Glu Asn Ser Ser Ala Pro Ile Cys Glu Asn
        1475                1480                1485            
Lys Pro Lys Ile Leu Asn Ser Glu Glu Trp Phe Ala Ala Ala Cys Lys
    1490                1495                1500                
Lys Glu Leu Lys Glu Asn Ile Gln Thr Thr Asn Tyr Asn Thr Ala Leu
1505                1510                1515                1520
Asp Phe His Ser Asn Ser Asp Val Thr Lys Gln Val Ile Gln Thr His
                1525                1530                1535    
Val Asn Ala Gly Glu Ala Pro Asp Pro Val Ile Thr Ser Asn Val Pro
            1540                1545                1550        
Cys Phe His Ser Ile Lys Pro Asn Leu Asn Asn Leu Asn Gly Lys Thr
        1555                1560                1565            
Gly Glu Phe Leu Ala Phe Gln Thr Val His Leu Pro Pro Leu Pro Glu
    1570                1575                1580                
Gln Leu Leu Glu Leu Gly Asn Lys Ala His Asn Asp Met His Ile Val
1585                1590                1595                1600
Gln Ala Thr Glu Ile His Asn Ile Asn Ile Ile Ser Ser Asn Ala Lys
                1605                1610                1615    
Asp Ser Arg Asp Glu Glu Asn Lys Lys Ser His Asn Gly Ala Glu Thr
            1620                1625                1630        
Thr Ser Leu Pro Pro Lys Thr Val Phe Lys Asp Lys Val Arg Arg Cys
        1635                1640                1645            
Ser Leu Gly Ile Phe Leu Pro Arg Leu Pro Asn Lys Arg Asn Cys Ser
    1650                1655                1660                
Val Thr Gly Ile Asp Asp Leu Glu Gln Ile Pro Ala Asp Thr Thr Asp
1665                1670                1675                1680
Ile Asn His Leu Glu Thr Gln Pro Val Ser Ser Lys Asp Ser Gly Ile
                1685                1690                1695    
Gly Ser Val Ala Gly Lys Leu Asn Leu Ser Pro Ser Gln Tyr Ile Asn
            1700                1705                1710        
Glu Glu Asn Leu Pro Val Tyr Pro Asp Glu Ile Asn Ser Ser Asp Ser
        1715                1720                1725            
Ile Asn Ile Glu Thr Glu Glu Lys Ala Leu Ile Glu Thr Tyr Gln Lys
    1730                1735                1740                
Glu Ile Ser Pro Tyr Glu Asn Lys Met Gly Lys Thr Cys Asn Ser Gln
1745                1750                1755                1760
Lys Arg Thr Trp Val Gln Glu Glu Glu Asp Ile His Lys Glu Lys Lys
                1765                1770                1775    
Ile Arg Lys Asn Glu Ile Lys Phe Ser Asp Thr Thr Gln Asp Arg Glu
            1780                1785                1790        
Val Ser Ser Val Leu Asn Gln Arg Met Phe Leu Asn Phe Gly Phe Cys
        1795                1800                1805            
Phe Val Phe Leu Asn Cys Gly Tyr Ser Gln Ile Leu Ile Leu Val Ser
    1810                1815                1820                
Gly Arg Gln Lys Ile Ile Ile Ser Thr
1825                1830            


<210> 2069
<211> 1050
<212> PRT
<213> Homo sapiens

<400> 2069
Met Ala Ala Val Lys Lys Glu Gly Gly Ala Leu Ser Glu Ala Met Ser
 1               5                  10                  15      
Leu Glu Gly Asp Glu Trp Glu Leu Ser Lys Glu Asn Val Gln Pro Leu
            20                  25                  30          
Arg Gln Gly Arg Ile Met Ser Thr Leu Gln Gly Ala Leu Ala Gln Glu
        35                  40                  45              
Ser Ala Cys Asn Asn Thr Leu Gln Gln Gln Lys Arg Ala Phe Glu Tyr
    50                  55                  60                  
Glu Ile Arg Phe Tyr Thr Gly Asn Asp Pro Leu Asp Val Trp Asp Arg
65                  70                  75                  80  
Tyr Ile Ser Trp Thr Glu Gln Asn Tyr Pro Gln Gly Gly Lys Glu Ser
                85                  90                  95      
Asn Met Ser Thr Leu Leu Glu Arg Ala Val Glu Ala Leu Gln Gly Glu
            100                 105                 110         
Lys Arg Tyr Tyr Ser Asp Pro Arg Phe Leu Asn Leu Trp Leu Lys Leu
        115                 120                 125             
Gly Arg Leu Cys Asn Glu Pro Leu Asp Met Tyr Ser Tyr Leu His Asn
    130                 135                 140                 
Gln Gly Ile Gly Val Ser Leu Ala Gln Phe Tyr Ile Ser Trp Ala Glu
145                 150                 155                 160 
Glu Tyr Glu Ala Arg Glu Asn Phe Arg Lys Ala Asp Ala Ile Phe Gln
                165                 170                 175     
Glu Gly Ile Gln Gln Lys Ala Glu Pro Leu Glu Arg Leu Gln Ser Gln
            180                 185                 190         
His Arg Gln Phe Gln Ala Arg Val Ser Arg Gln Thr Leu Leu Ala Leu
        195                 200                 205             
Glu Lys Glu Glu Glu Glu Glu Val Phe Glu Ser Ser Val Pro Gln Arg
    210                 215                 220                 
Ser Thr Leu Ala Glu Leu Lys Ser Lys Gly Lys Lys Thr Ala Arg Ala
225                 230                 235                 240 
Pro Ile Ile Arg Val Gly Gly Ala Leu Lys Ala Pro Ser Gln Asn Arg
                245                 250                 255     
Gly Leu Gln Asn Pro Phe Pro Gln Gln Met Gln Asn Asn Ser Arg Ile
            260                 265                 270         
Thr Val Phe Asp Glu Asn Ala Asp Glu Ala Ser Thr Ala Glu Leu Ser
        275                 280                 285             
Lys Pro Thr Val Gln Pro Trp Ile Ala Pro Pro Met Pro Arg Ala Lys
    290                 295                 300                 
Glu Asn Glu Leu Gln Ala Gly Pro Trp Asn Thr Gly Arg Ser Leu Glu
305                 310                 315                 320 
His Arg Pro Arg Gly Asn Thr Ala Ser Leu Ile Ala Val Pro Ala Val
                325                 330                 335     
Leu Pro Ser Phe Thr Pro Tyr Val Glu Glu Thr Ala Arg Gln Pro Val
            340                 345                 350         
Met Thr Pro Cys Lys Ile Glu Pro Ser Ile Asn His Ile Leu Ser Thr
        355                 360                 365             
Arg Lys Pro Gly Lys Glu Glu Gly Asp Pro Leu Gln Arg Val Gln Ser
    370                 375                 380                 
His Gln Gln Ala Ser Glu Glu Lys Lys Glu Lys Met Met Tyr Cys Lys
385                 390                 395                 400 
Glu Lys Ile Tyr Ala Gly Val Gly Glu Phe Ser Phe Glu Glu Ile Arg
                405                 410                 415     
Ala Glu Val Phe Arg Lys Lys Leu Lys Glu Gln Arg Glu Ala Glu Leu
            420                 425                 430         
Leu Thr Ser Ala Glu Lys Arg Ala Glu Met Gln Lys Gln Ile Glu Glu
        435                 440                 445             
Met Glu Lys Lys Leu Lys Glu Ile Gln Thr Thr Gln Gln Glu Arg Thr
    450                 455                 460                 
Gly Asp Gln Gln Glu Glu Thr Met Pro Thr Lys Glu Thr Thr Lys Leu
465                 470                 475                 480 
Gln Ile Ala Ser Glu Ser Gln Lys Ile Pro Gly Met Thr Leu Ser Ser
                485                 490                 495     
Ser Val Cys Gln Val Asn Cys Cys Ala Arg Glu Thr Ser Leu Ala Glu
            500                 505                 510         
Asn Ile Trp Gln Glu Gln Pro His Ser Lys Gly Pro Ser Val Pro Phe
        515                 520                 525             
Ser Ile Phe Asp Glu Phe Leu Leu Ser Glu Lys Lys Asn Lys Ser Pro
    530                 535                 540                 
Pro Ala Asp Pro Pro Arg Val Leu Ala Gln Arg Arg Pro Leu Ala Val
545                 550                 555                 560 
Leu Lys Thr Ser Glu Ser Ile Thr Ser Asn Glu Asp Val Ser Pro Asp
                565                 570                 575     
Val Cys Asp Glu Phe Thr Gly Ile Glu Pro Leu Ser Glu Asp Ala Ile
            580                 585                 590         
Ile Thr Gly Phe Arg Asn Val Thr Ile Cys Pro Asn Pro Glu Asp Thr
        595                 600                 605             
Cys Asp Phe Ala Arg Ala Ala Arg Phe Val Ser Thr Pro Phe His Glu
    610                 615                 620                 
Ile Met Ser Leu Lys Asp Leu Pro Ser Asp Pro Glu Arg Leu Leu Pro
625                 630                 635                 640 
Glu Glu Asp Leu Asp Val Lys Thr Ser Glu Asp Gln Gln Thr Ala Cys
                645                 650                 655     
Gly Thr Ile Tyr Ser Gln Thr Leu Ser Ile Lys Lys Leu Ser Pro Ile
            660                 665                 670         
Ile Glu Asp Ser Arg Glu Ala Thr His Ser Ser Gly Phe Ser Gly Ser
        675                 680                 685             
Ser Ala Ser Val Ala Ser Thr Ser Ser Ile Lys Cys Leu Gln Ile Pro
    690                 695                 700                 
Glu Lys Leu Glu Leu Thr Asn Glu Thr Ser Glu Asn Pro Thr Gln Ser
705                 710                 715                 720 
Pro Trp Cys Ser Gln Tyr Arg Arg Gln Leu Leu Lys Ser Leu Pro Glu
                725                 730                 735     
Leu Ser Ala Ser Ala Glu Leu Cys Ile Glu Asp Arg Pro Met Pro Lys
            740                 745                 750         
Leu Glu Ile Glu Lys Glu Ile Glu Leu Gly Asn Glu Asp Tyr Cys Ile
        755                 760                 765             
Lys Arg Glu Tyr Leu Ile Cys Glu Asp Tyr Lys Leu Phe Trp Val Ala
    770                 775                 780                 
Pro Arg Asn Ser Ala Glu Leu Thr Val Ile Lys Val Ser Ser Gln Pro
785                 790                 795                 800 
Val Pro Trp Asp Phe Tyr Ile Asn Leu Lys Leu Lys Glu Arg Leu Asn
                805                 810                 815     
Glu Asp Phe Asp His Phe Cys Ser Cys Tyr Gln Tyr Gln Asp Gly Cys
            820                 825                 830         
Ile Val Trp His Gln Tyr Ile Asn Cys Phe Thr Leu Gln Asp Leu Leu
        835                 840                 845             
Gln His Ser Glu Tyr Ile Thr His Glu Ile Thr Val Leu Ile Ile Tyr
    850                 855                 860                 
Asn Leu Leu Thr Ile Val Glu Met Leu His Lys Ala Glu Ile Val His
865                 870                 875                 880 
Gly Asp Leu Ser Pro Arg Cys Leu Ile Leu Arg Asn Arg Ile His Asp
                885                 890                 895     
Pro Tyr Asp Cys Asn Lys Asn Asn Gln Ala Leu Lys Ile Val Asp Phe
            900                 905                 910         
Ser Tyr Ser Val Asp Leu Arg Val Gln Leu Asp Val Phe Thr Leu Ser
        915                 920                 925             
Gly Phe Arg Thr Val Gln Ile Leu Glu Gly Gln Lys Ile Leu Ala Asn
    930                 935                 940                 
Cys Ser Ser Pro Tyr Gln Val Asp Leu Phe Gly Ile Ala Asp Leu Ala
945                 950                 955                 960 
His Leu Leu Leu Phe Lys Glu His Leu Gln Val Phe Trp Asp Gly Ser
                965                 970                 975     
Phe Trp Lys Leu Ser Gln Asn Ile Ser Glu Leu Lys Asp Gly Glu Leu
            980                 985                 990         
Trp Asn Lys Phe Phe Val Arg Ile Leu Asn Ala Asn Asp Glu Ala Thr
        995                 1000                1005            
Val Ser Val Leu Gly Glu Leu Ala Ala Glu Met Asn Gly Val Phe Asp
    1010                1015                1020                
Thr Thr Phe Gln Ser His Leu Asn Lys Ala Leu Trp Lys Val Gly Lys
1025                1030                1035                1040
Leu Thr Ser Pro Gly Ala Leu Leu Phe Gln
                1045                1050


<210> 2070
<211> 1455
<212> PRT
<213> Homo sapiens

<400> 2070
Met Ala Lys Gln Glu Arg Leu Glu Ile Ala Ser Leu Ser Asn Gln Asp
 1               5                  10                  15      
His Thr Ser Lys Lys Asp Pro Gly Gly His Arg Thr Ala Ala Ile Leu
            20                  25                  30          
His Gly Gly Ser Pro Asp Phe Val Gly Asn Gly Lys His Arg Ala Asn
        35                  40                  45              
Ser Ser Gly Arg Ser Arg Arg Glu Arg Gln Tyr Ser Val Cys Asn Ser
    50                  55                  60                  
Glu Asp Ser Pro Gly Ser Cys Glu Ile Leu Tyr Phe Asn Met Gly Ser
65                  70                  75                  80  
Pro Asp Gln Leu Met Val His Lys Gly Lys Cys Ile Gly Ser Asp Glu
                85                  90                  95      
Gln Leu Gly Lys Leu Val Tyr Asn Ala Leu Glu Thr Ala Thr Gly Gly
            100                 105                 110         
Phe Val Leu Leu Tyr Glu Trp Val Leu Gln Trp Gln Lys Lys Met Gly
        115                 120                 125             
Pro Phe Leu Thr Ser Gln Glu Lys Glu Lys Ile Asp Lys Cys Lys Lys
    130                 135                 140                 
Gln Ile Gln Gly Thr Glu Thr Glu Phe Asn Ser Leu Val Lys Leu Ser
145                 150                 155                 160 
His Pro Asn Val Val Arg Tyr Leu Ala Met Asn Leu Lys Glu Gln Asp
                165                 170                 175     
Asp Ser Ile Val Val Asp Ile Leu Val Glu His Ile Ser Gly Val Ser
            180                 185                 190         
Leu Ala Ala His Leu Ser His Ser Gly Pro Ile Pro Val His Gln Leu
        195                 200                 205             
Arg Arg Tyr Thr Ala Gln Leu Leu Ser Gly Leu Asp Tyr Leu His Ser
    210                 215                 220                 
Asn Ser Val Val His Lys Val Leu Ser Ala Ser Asn Val Leu Val Asp
225                 230                 235                 240 
Ala Glu Gly Thr Val Lys Ile Thr Asp Tyr Ser Ile Ser Lys Arg Leu
                245                 250                 255     
Ala Asp Ile Cys Lys Glu Asp Val Phe Glu Gln Thr Arg Val Arg Phe
            260                 265                 270         
Ser Asp Asn Ala Leu Pro Tyr Lys Thr Gly Lys Lys Gly Asp Val Trp
        275                 280                 285             
Arg Leu Gly Leu Leu Leu Leu Ser Leu Ser Gln Gly Gln Glu Cys Gly
    290                 295                 300                 
Glu Tyr Pro Val Thr Ile Pro Ser Asp Leu Pro Ala Asp Phe Gln Asp
305                 310                 315                 320 
Phe Leu Lys Lys Cys Val Cys Leu Asp Asp Lys Glu Arg Trp Ser Pro
                325                 330                 335     
Gln Gln Leu Leu Lys His Ser Phe Ile Asn Pro Gln Pro Lys Met Pro
            340                 345                 350         
Leu Val Glu Gln Ser Pro Glu Asp Ser Glu Gly Gln Asp Tyr Val Glu
        355                 360                 365             
Thr Val Ile Pro Ser Asn Arg Leu Pro Ser Ala Ala Phe Phe Ser Glu
    370                 375                 380                 
Thr Gln Arg Gln Phe Ser Arg Tyr Phe Ile Glu Phe Glu Glu Leu Gln
385                 390                 395                 400 
Leu Leu Gly Lys Gly Ala Phe Gly Ala Val Ile Lys Val Gln Asn Lys
                405                 410                 415     
Leu Asp Gly Cys Cys Tyr Ala Val Lys Arg Ile Pro Ile Asn Pro Ala
            420                 425                 430         
Ser Arg Gln Phe Arg Arg Ile Lys Gly Glu Val Thr Leu Leu Ser Arg
        435                 440                 445             
Leu His His Glu Asn Ile Val Arg Tyr Tyr Asn Ala Trp Ile Glu Arg
    450                 455                 460                 
His Glu Arg Pro Ala Gly Pro Gly Thr Pro Pro Pro Asp Ser Gly Pro
465                 470                 475                 480 
Leu Ala Lys Asp Asp Arg Ala Ala Arg Gly Gln Pro Ala Ser Asp Thr
                485                 490                 495     
Asp Gly Leu Asp Ser Val Glu Ala Ala Ala Pro Pro Pro Ile Leu Ser
            500                 505                 510         
Ser Ser Val Glu Trp Ser Thr Ser Gly Glu Arg Ser Ala Ser Ala Arg
        515                 520                 525             
Phe Pro Ala Thr Gly Pro Gly Ser Ser Asp Asp Glu Asp Asp Asp Glu
    530                 535                 540                 
Asp Glu His Gly Gly Val Phe Ser Gln Ser Phe Leu Pro Ala Ser Asp
545                 550                 555                 560 
Ser Glu Ser Asp Ile Ile Phe Asp Asn Glu Asp Glu Asn Ser Lys Ser
                565                 570                 575     
Gln Asn Gln Asp Glu Asp Cys Asn Glu Lys Asn Gly Cys His Glu Ser
            580                 585                 590         
Glu Pro Ser Val Thr Thr Glu Ala Val His Tyr Leu Tyr Ile Gln Met
        595                 600                 605             
Glu Tyr Cys Glu Lys Ser Thr Leu Arg Asp Thr Ile Asp Gln Gly Leu
    610                 615                 620                 
Tyr Arg Asp Thr Val Arg Leu Trp Arg Leu Phe Arg Glu Ile Leu Asp
625                 630                 635                 640 
Gly Leu Ala Tyr Ile His Glu Lys Gly Met Ile His Arg Asp Leu Lys
                645                 650                 655     
Pro Val Asn Ile Phe Leu Asp Ser Asp Asp His Val Lys Ile Gly Asp
            660                 665                 670         
Phe Gly Leu Ala Thr Asp His Leu Ala Phe Ser Ala Asp Ser Lys Gln
        675                 680                 685             
Asp Asp Gln Thr Gly Asp Leu Ile Lys Ser Asp Pro Ser Gly His Leu
    690                 695                 700                 
Thr Gly Met Val Gly Thr Ala Leu Tyr Val Ser Pro Glu Val Gln Gly
705                 710                 715                 720 
Ser Thr Lys Ser Ala Tyr Asn Gln Lys Val Asp Leu Phe Ser Leu Gly
                725                 730                 735     
Ile Ile Phe Phe Glu Met Ser Tyr His Pro Met Val Thr Ala Ser Glu
            740                 745                 750         
Arg Ile Phe Val Leu Asn Gln Leu Arg Asp Pro Thr Ser Pro Lys Phe
        755                 760                 765             
Pro Glu Asp Phe Asp Asp Gly Glu His Ala Lys Gln Lys Ser Val Ile
    770                 775                 780                 
Ser Trp Leu Leu Asn His Asp Pro Ala Lys Arg Pro Thr Ala Thr Glu
785                 790                 795                 800 
Leu Leu Lys Ser Glu Leu Leu Pro Pro Pro Gln Met Glu Glu Ser Glu
                805                 810                 815     
Leu His Glu Val Leu His His Thr Leu Thr Asn Val Asp Gly Lys Ala
            820                 825                 830         
Tyr Arg Thr Met Met Ala Gln Ile Phe Ser Gln Arg Ile Ser Pro Ala
        835                 840                 845             
Ile Asp Tyr Thr Tyr Asp Ser Asp Ile Leu Lys Gly Asn Phe Ser Ile
    850                 855                 860                 
Arg Thr Ala Lys Met Gln Gln His Val Cys Glu Thr Ile Ile Arg Ile
865                 870                 875                 880 
Phe Lys Arg His Gly Ala Val Gln Leu Cys Thr Pro Leu Leu Leu Pro
                885                 890                 895     
Arg Asn Arg Gln Ile Tyr Glu His Asn Glu Ala Ala Leu Phe Met Asp
            900                 905                 910         
His Ser Gly Met Leu Val Met Leu Pro Phe Asp Leu Arg Ile Pro Phe
        915                 920                 925             
Ala Arg Tyr Val Ala Arg Asn Asn Ile Leu Asn Leu Lys Arg Tyr Cys
    930                 935                 940                 
Ile Glu Arg Val Phe Arg Pro Arg Lys Leu Asp Arg Phe His Pro Lys
945                 950                 955                 960 
Glu Leu Leu Glu Cys Ala Phe Asp Ile Val Thr Ser Thr Thr Asn Ser
                965                 970                 975     
Phe Leu Pro Thr Ala Glu Ile Ile Tyr Thr Ile Tyr Glu Ile Ile Gln
            980                 985                 990         
Glu Phe Pro Ala Leu Gln Glu Arg Asn Tyr Ser Ile Tyr Leu Asn His
        995                 1000                1005            
Thr Met Leu Leu Lys Ala Ile Leu Leu His Cys Gly Ile Pro Glu Asp
    1010                1015                1020                
Lys Leu Ser Gln Val Tyr Ile Ile Leu Tyr Asp Ala Val Thr Glu Lys
1025                1030                1035                1040
Leu Thr Arg Arg Glu Val Glu Ala Lys Phe Cys Asn Leu Ser Leu Ser
                1045                1050                1055    
Ser Asn Ser Leu Cys Arg Leu Tyr Lys Phe Ile Glu Gln Lys Gly Asp
            1060                1065                1070        
Leu Gln Asp Leu Met Pro Thr Ile Asn Ser Leu Ile Lys Gln Lys Thr
        1075                1080                1085            
Gly Ile Ala Gln Leu Val Lys Tyr Gly Leu Lys Asp Leu Glu Glu Val
    1090                1095                1100                
Val Gly Leu Leu Lys Lys Leu Gly Ile Lys Leu Gln Val Leu Ile Asn
1105                1110                1115                1120
Leu Gly Leu Val Tyr Lys Val Gln Gln His Asn Gly Ile Ile Phe Gln
                1125                1130                1135    
Phe Val Ala Phe Ile Lys Arg Arg Gln Arg Ala Val Pro Glu Ile Leu
            1140                1145                1150        
Ala Ala Gly Gly Arg Tyr Asp Leu Leu Ile Pro Gln Phe Arg Gly Pro
        1155                1160                1165            
Gln Ala Leu Gly Pro Val Pro Thr Ala Ile Gly Val Ser Ile Ala Ile
    1170                1175                1180                
Asp Lys Ile Ser Ala Ala Val Leu Asn Met Glu Glu Ser Val Thr Ile
1185                1190                1195                1200
Ser Ser Cys Asp Leu Leu Val Val Ser Val Gly Gln Met Ser Met Ser
                1205                1210                1215    
Arg Ala Ile Asn Leu Thr Gln Lys Leu Trp Thr Ala Gly Ile Thr Ala
            1220                1225                1230        
Glu Ile Met Tyr Asp Trp Ser Gln Ser Gln Glu Glu Leu Gln Glu Tyr
        1235                1240                1245            
Cys Arg His His Glu Ile Thr Tyr Val Ala Leu Val Ser Asp Lys Glu
    1250                1255                1260                
Gly Ser His Val Lys Val Lys Ser Phe Glu Lys Glu Arg Gln Thr Glu
1265                1270                1275                1280
Lys Arg Val Leu Glu Thr Glu Leu Val Asp His Val Leu Gln Lys Leu
                1285                1290                1295    
Arg Thr Lys Val Thr Asp Glu Arg Asn Gly Arg Glu Ala Ser Asp Asn
            1300                1305                1310        
Leu Ala Val Gln Asn Leu Lys Gly Ser Phe Ser Asn Ala Ser Gly Leu
        1315                1320                1325            
Phe Glu Ile His Gly Ala Thr Val Val Pro Ile Val Ser Val Leu Ala
    1330                1335                1340                
Pro Glu Lys Leu Ser Ala Ser Thr Arg Arg Arg Tyr Glu Thr Gln Val
1345                1350                1355                1360
Gln Thr Arg Leu Gln Thr Ser Leu Ala Asn Leu His Gln Lys Ser Ser
                1365                1370                1375    
Glu Ile Glu Ile Leu Ala Val Asp Leu Pro Lys Glu Thr Ile Leu Gln
            1380                1385                1390        
Phe Leu Ser Leu Glu Trp Asp Ala Asp Glu Gln Ala Phe Asn Thr Thr
        1395                1400                1405            
Val Lys Gln Leu Leu Ser Arg Leu Pro Lys Gln Arg Tyr Leu Lys Leu
    1410                1415                1420                
Val Cys Asp Glu Ile Tyr Asn Ile Lys Val Glu Lys Lys Val Ser Val
1425                1430                1435                1440
Leu Phe Leu Tyr Ser Tyr Arg Asp Asp Tyr Tyr Arg Ile Leu Phe
                1445                1450                1455


<210> 2071
<211> 585
<212> PRT
<213> Homo sapiens

<400> 2071
Met Lys Lys Gln Ala Asn Lys Thr Ala Ser Ser Gly Ser Ser Asp Lys
 1               5                  10                  15      
Asp Ser Ser Ala Glu Ser Ser Ala Pro Glu Glu Gly Glu Val Ser Asp
            20                  25                  30          
Ser Asp Ser Asn Ser Ser Ser Ser Ser Ser Asp Ser Asp Ser Ser Ser
        35                  40                  45              
Glu Asp Glu Glu Phe His Asp Gly Tyr Gly Glu Asp Leu Met Gly Asp
    50                  55                  60                  
Glu Glu Asp Arg Ala Arg Leu Glu Gln Met Thr Glu Lys Glu Arg Glu
65                  70                  75                  80  
Gln Glu Leu Phe Asn Arg Ile Glu Lys Arg Glu Val Leu Lys Arg Arg
                85                  90                  95      
Phe Glu Ile Lys Lys Lys Leu Lys Thr Ala Lys Lys Lys Glu Lys Lys
            100                 105                 110         
Glu Lys Lys Lys Lys Gln Glu Glu Glu Gln Glu Lys Lys Lys Leu Thr
        115                 120                 125             
Gln Ile Gln Glu Ser Gln Val Thr Ser His Asn Lys Glu Arg Arg Ser
    130                 135                 140                 
Lys Arg Asp Glu Lys Leu Asp Lys Lys Ser Gln Ala Met Glu Glu Leu
145                 150                 155                 160 
Lys Ala Glu Arg Glu Lys Arg Lys Asn Arg Thr Ala Glu Leu Leu Ala
                165                 170                 175     
Lys Lys Gln Pro Leu Lys Thr Ser Glu Val Tyr Ser Asp Asp Glu Glu
            180                 185                 190         
Glu Glu Glu Asp Asp Lys Ser Ser Glu Lys Ser Asp Arg Ser Ser Arg
        195                 200                 205             
Thr Ser Ser Ser Asp Glu Glu Glu Glu Lys Glu Glu Ile Pro Pro Lys
    210                 215                 220                 
Ser Gln Pro Val Ser Leu Pro Glu Glu Leu Asn Arg Val Arg Leu Ser
225                 230                 235                 240 
Arg His Lys Leu Glu Arg Trp Cys His Met Pro Phe Phe Ala Lys Thr
                245                 250                 255     
Val Thr Gly Cys Phe Val Arg Ile Gly Ile Gly Asn His Asn Ser Lys
            260                 265                 270         
Pro Val Tyr Arg Val Ala Glu Ile Thr Gly Val Val Glu Thr Ala Lys
        275                 280                 285             
Val Tyr Gln Leu Gly Gly Thr Arg Thr Asn Lys Gly Leu Gln Leu Arg
    290                 295                 300                 
His Gly Asn Asp Gln Arg Val Phe Arg Leu Glu Phe Val Ser Asn Gln
305                 310                 315                 320 
Glu Phe Thr Glu Ser Glu Phe Met Lys Trp Lys Glu Ala Met Phe Ser
                325                 330                 335     
Ala Gly Met Gln Leu Pro Thr Leu Asp Glu Ile Asn Lys Lys Glu Leu
            340                 345                 350         
Ser Ile Lys Glu Ala Leu Asn Tyr Lys Phe Asn Asp Gln Asp Ile Glu
        355                 360                 365             
Glu Ile Val Lys Glu Lys Glu Arg Phe Arg Lys Ala Pro Pro Asn Tyr
    370                 375                 380                 
Ala Met Lys Lys Thr Gln Leu Leu Lys Glu Lys Ala Met Ala Glu Asp
385                 390                 395                 400 
Leu Gly Asp Gln Asp Lys Ala Lys Gln Ile Gln Asp Gln Leu Asn Glu
                405                 410                 415     
Leu Glu Glu Arg Ala Glu Ala Leu Asp Arg Gln Arg Thr Lys Asn Ile
            420                 425                 430         
Ser Ala Ile Ser Tyr Ile Asn Gln Arg Asn Arg Glu Trp Asn Ile Val
        435                 440                 445             
Glu Ser Glu Lys Ala Leu Val Ala Glu Ser His Asn Met Lys Asn Gln
    450                 455                 460                 
Gln Met Asp Pro Phe Thr Arg Arg Gln Cys Lys Pro Thr Ile Val Ser
465                 470                 475                 480 
Asn Ser Arg Asp Pro Ala Val Gln Ala Ala Ile Leu Ala Gln Leu Asn
                485                 490                 495     
Ala Lys Tyr Gly Ser Gly Val Leu Pro Asp Ala Pro Lys Glu Met Ser
            500                 505                 510         
Lys Gly Gln Gly Lys Asp Lys Asp Leu Asn Ser Lys Ser Ala Ser Asp
        515                 520                 525             
Leu Ser Glu Asp Leu Phe Lys Val His Asp Phe Asp Val Lys Ile Asp
    530                 535                 540                 
Leu Gln Val Pro Ser Ser Glu Ser Lys Ala Leu Ala Ile Thr Ser Lys
545                 550                 555                 560 
Ala Pro Pro Ala Lys Asp Gly Ala Pro Arg Arg Ser Leu Asn Leu Glu
                565                 570                 575     
Asp Tyr Lys Lys Arg Arg Gly Leu Ile
            580                 585 


<210> 2072
<211> 106
<212> PRT
<213> Homo sapiens

<400> 2072
Met Lys Met Trp Asn Pro Val Tyr Tyr Trp Gly Gly Gly Arg Trp Glu
 1               5                  10                  15      
Gly Val Gly Cys Lys Cys Leu Leu Ile Glu Glu Ala Leu Ile Gln Ala
            20                  25                  30          
Pro Ile Thr Ile Pro Ile Pro Ser Ser Ile Ser His Arg Leu Ser Pro
        35                  40                  45              
Thr Ser Leu Val Phe Cys Phe Ser Val Gly Asp Thr Gly Pro Arg Arg
    50                  55                  60                  
Leu Gly Ser Pro Gly Cys Cys Gly Pro Cys Ala Pro Leu Tyr Leu Pro
65                  70                  75                  80  
Ala Pro Gly Pro Gly Ala Cys His Gln Leu Gln Pro Gln Gly Ala Leu
                85                  90                  95      
Cys Gln Cys Leu Gly Ala Leu Ser Leu Cys
            100                 105     


<210> 2073
<211> 913
<212> PRT
<213> Homo sapiens

<400> 2073
Met Gly Ser Gln Thr Leu Gln Ile Leu Arg Gln Gly Val Trp Ala Ala
 1               5                  10                  15      
Leu Ser Gly Gly Trp Tyr Tyr Asp Pro His Gln Ala Thr Phe Val Asn
            20                  25                  30          
Ala Leu His Leu Tyr Leu Trp Leu Phe Leu Leu Gly Leu Pro Phe Thr
        35                  40                  45              
Leu Tyr Met Ala Leu Pro Ser Thr Met Ile Ile Val Ala Val Tyr Cys
    50                  55                  60                  
Pro Val Ile Ala Ala Val Phe Ile Val Leu Lys Met Val Asn Tyr Arg
65                  70                  75                  80  
Leu His Arg Ala Leu Asp Ala Gly Glu Val Val Asp Arg Thr Ala Asn
                85                  90                  95      
Glu Phe Thr Asp Gln Arg Thr Lys Ala Glu Gln Gly Asn Cys Ser Thr
            100                 105                 110         
Arg Arg Lys Asp Ser Asn Gly Pro Ser Asp Pro Gly Gly Gly Ile Glu
        115                 120                 125             
Met Ser Glu Phe Ile Arg Glu Ala Thr Pro Pro Val Gly Cys Ser Ser
    130                 135                 140                 
Arg Asn Ser Tyr Ala Gly Leu Asp Pro Ser Asn Gln Ile Gly Ser Gly
145                 150                 155                 160 
Ser Ser Arg Leu Gly Thr Ala Ala Thr Ile Lys Gly Asp Thr Asp Thr
                165                 170                 175     
Ala Lys Thr Ser Asp Asp Ile Ser Leu Ser Leu Gly Gln Ser Ser Ser
            180                 185                 190         
Leu Cys Lys Glu Gly Ser Glu Glu Gln Asp Leu Ala Ala Asp Arg Lys
        195                 200                 205             
Leu Phe Arg Leu Val Ser Asn Asp Ser Phe Ile Ser Ile Gln Pro Ser
    210                 215                 220                 
Leu Ser Ser Cys Gly Gln Asp Leu Pro Arg Asp Phe Ser Asp Lys Val
225                 230                 235                 240 
Asn Leu Pro Ser His Asn His His His His Val Asp Gln Ser Leu Ser
                245                 250                 255     
Ser Ala Cys Asp Thr Glu Val Ala Ser Leu Val Pro Leu His Ser His
            260                 265                 270         
Ser Tyr Arg Lys Asp His Arg Pro Arg Gly Val Pro Arg Thr Ser Ser
        275                 280                 285             
Ser Ala Val Ala Phe Pro Asp Thr Ser Leu Asn Asp Phe Pro Leu Tyr
    290                 295                 300                 
Gln Gln Arg Arg Gly Leu Asp Pro Val Ser Glu Leu Glu Ser Ser Lys
305                 310                 315                 320 
Pro Leu Ser Gly Ser Lys Glu Ser Leu Val Glu Asn Ser Gly Leu Ser
                325                 330                 335     
Gly Glu Phe Gln Leu Ala Gly Asp Leu Lys Ile Asn Thr Ser Gln Pro
            340                 345                 350         
Pro Thr Lys Ser Gly Lys Ser Lys Pro Leu Lys Ala Glu Lys Ser Met
        355                 360                 365             
Asp Ser Leu Arg Ser Leu Ser Thr Arg Ser Ser Gly Ser Thr Glu Ser
    370                 375                 380                 
Tyr Cys Ser Gly Thr Asp Arg Asp Thr Asn Ser Thr Val Ser Ser Tyr
385                 390                 395                 400 
Lys Ser Glu Gln Thr Ser Ser Thr His Ile Glu Ser Ile Leu Ser Glu
                405                 410                 415     
His Glu Glu Ser Pro Lys Ala Gly Thr Lys Ser Gly Arg Lys Lys Glu
            420                 425                 430         
Cys Cys Ala Gly Pro Glu Glu Lys Asn Ser Cys Ala Ser Asp Lys Arg
        435                 440                 445             
Thr Ser Ser Glu Lys Ile Ala Met Glu Ala Ser Thr Asn Ser Gly Val
    450                 455                 460                 
His Glu Ala Lys Asp Pro Thr Pro Ser Asp Glu Met His Asn Gln Arg
465                 470                 475                 480 
Gly Leu Ser Thr Ser Ala Ser Glu Glu Ala Asn Lys Asn Pro His Ala
                485                 490                 495     
Asn Glu Phe Thr Ser Gln Gly Asp Arg Pro Pro Gly Asn Thr Ala Glu
            500                 505                 510         
Asn Lys Glu Glu Lys Ser Asp Lys Ser Ala Val Ser Val Asp Ser Lys
        515                 520                 525             
Val Arg Lys Asp Val Gly Gly Lys Gln Lys Glu Gly Asp Val Arg Pro
    530                 535                 540                 
Lys Ser Ser Ser Val Ile His Arg Thr Ala Ser Ala His Lys Ser Gly
545                 550                 555                 560 
Arg Arg Arg Thr Gly Lys Lys Arg Ala Ser Ser Phe Asp Ser Ser Arg
                565                 570                 575     
His Arg Asp Tyr Val Cys Phe Arg Gly Val Ser Gly Thr Lys Pro His
            580                 585                 590         
Ser Ala Ile Phe Cys His Asp Glu Asp Ser Ser Asp Gln Ser Asp Leu
        595                 600                 605             
Ser Arg Ala Ser Ser Val Gln Ser Ala His Gln Phe Ser Ser Asp Ser
    610                 615                 620                 
Ser Ser Ser Thr Thr Ser His Ser Cys Gln Ser Pro Glu Gly Arg Tyr
625                 630                 635                 640 
Ser Ala Leu Lys Thr Lys His Thr His Lys Glu Arg Gly Thr Asp Ser
                645                 650                 655     
Glu His Thr His Lys Ala His Leu Val Pro Glu Gly Thr Ser Lys Lys
            660                 665                 670         
Arg Ala Thr Arg Arg Thr Ser Ser Thr Asn Ser Ala Lys Thr Arg Ala
        675                 680                 685             
Arg Val Leu Ser Leu Asp Ser Gly Thr Val Ala Cys Leu Asn Asp Ser
    690                 695                 700                 
Asn Arg Leu Met Ala Pro Glu Ser Ile Lys Pro Leu Thr Thr Ser Lys
705                 710                 715                 720 
Ser Asp Leu Glu Ala Lys Glu Gly Glu Val Leu Asp Glu Leu Ser Leu
                725                 730                 735     
Leu Gly Arg Ala Ser Gln Leu Glu Thr Val Thr Arg Ser Arg Asn Ser
            740                 745                 750         
Leu Pro Asn Gln Val Ala Phe Pro Glu Gly Glu Glu Gln Asp Ala Val
        755                 760                 765             
Ser Gly Ala Ala Gln Ala Ser Glu Glu Ala Val Ser Phe Arg Arg Glu
    770                 775                 780                 
Arg Ser Thr Phe Arg Arg Gln Ala Val Arg Arg Arg His Asn Ala Gly
785                 790                 795                 800 
Ser Asn Pro Thr Pro Pro Thr Leu Leu Ile Gly Ser Pro Leu Ser Leu
                805                 810                 815     
Gln Asp Gly Gln Gln Gly Gln Gln Ser Thr Ala Gln Val Lys Val Gln
            820                 825                 830         
Ser Arg Pro Pro Ser Gln Ala Ala Val Leu Ser Ala Ser Ala Ser Leu
        835                 840                 845             
Leu Gly Lys Phe Ser Ser Thr Leu Tyr Glu Thr Gly Gly Cys Asp Met
    850                 855                 860                 
Ser Leu Val Asn Phe Glu Pro Ala Ala Arg Arg Ala Ser Asn Ile Cys
865                 870                 875                 880 
Asp Thr Asp Ser His Val Ser Ser Ser Thr Ser Val Arg Phe Tyr Pro
                885                 890                 895     
His Asp Val Val Gly Phe Ser Leu Phe Leu Gln His Asp Lys Phe Ser
            900                 905                 910         
Asp
    


<210> 2074
<211> 478
<212> PRT
<213> Homo sapiens

<400> 2074
Met Asn Ser Ser Leu Gly Gly Ala Ser Leu Glu Gly Ser Gln Val Tyr
 1               5                  10                  15      
Leu Gly Leu Ser Pro Arg Asp Leu Val Leu His Phe Arg His Lys Val
            20                  25                  30          
Leu Ile Leu Phe Lys Leu Ile Leu Leu Glu Lys Lys Val Leu Phe Tyr
        35                  40                  45              
Ile Ser Pro Val Asn Lys Leu Val Gly Ala Leu Met Thr Val Leu Ser
    50                  55                  60                  
Leu Phe Pro Gly Met Ile Glu His Gly Leu Ser Asp Cys Ser Gln Tyr
65                  70                  75                  80  
Arg Pro Arg Lys Ser Met Ser Glu Asp Gly Gly Leu Gln Glu Ser Asn
                85                  90                  95      
Pro Cys Ala Asp Asp Phe Val Ser Ala Ser Thr Ala Asp Val Ser His
            100                 105                 110         
Thr Asn Leu Gly Thr Ile Arg Lys Val Met Ala Gly Asn His Gly Glu
        115                 120                 125             
Asp Ala Ala Met Lys Thr Glu Glu Pro Leu Phe Gln Val Glu Asp Ser
    130                 135                 140                 
Ser Lys Gly Gln Glu Pro Asn Asp Thr Asn Gln Tyr Leu Lys Pro Pro
145                 150                 155                 160 
Ser Arg Pro Ser Pro Asp Ser Ser Glu Ser Asp Trp Glu Thr Leu Asp
                165                 170                 175     
Pro Ser Val Leu Glu Asp Pro Asn Leu Lys Glu Arg Glu Gln Leu Gly
            180                 185                 190         
Ser Asp Gln Thr Asn Leu Phe Pro Lys Asp Ser Val Pro Ser Glu Ser
        195                 200                 205             
Leu Pro Ile Thr Val Gln Pro Gln Ala Asn Thr Gly Gln Val Val Leu
    210                 215                 220                 
Ile Pro Gly Leu Ile Ser Gly Leu Glu Glu Asp Gln Tyr Gly Met Pro
225                 230                 235                 240 
Leu Ala Ile Phe Thr Lys Gly Tyr Leu Cys Leu Pro Tyr Met Ala Leu
                245                 250                 255     
Gln Gln His His Leu Leu Ser Asp Val Thr Val Arg Gly Phe Val Ala
            260                 265                 270         
Gly Ala Thr Asn Ile Leu Phe Arg Gln Gln Lys His Leu Ser Asp Ala
        275                 280                 285             
Ile Val Glu Val Glu Glu Ala Leu Ile Gln Ile His Asp Pro Glu Leu
    290                 295                 300                 
Arg Lys Leu Leu Asn Pro Thr Thr Ala Asp Leu Arg Phe Ala Asp Tyr
305                 310                 315                 320 
Leu Val Arg His Val Thr Glu Asn Arg Asp Asp Val Phe Leu Asp Gly
                325                 330                 335     
Thr Gly Trp Glu Gly Gly Asp Glu Trp Ile Arg Ala Gln Phe Ala Val
            340                 345                 350         
Tyr Ile His Ala Leu Leu Ala Ala Thr Leu Gln Leu Val Leu Phe Arg
        355                 360                 365             
Ile Val Asn Val Ala Lys Lys Leu Glu Thr Ser Trp Ser Gln Leu Ala
    370                 375                 380                 
Gly Met Leu Tyr Lys Gln Glu Lys Leu Leu Ala Ser Gln Leu Glu Glu
385                 390                 395                 400 
Leu Phe Pro Val Gln Arg Gln Leu Cys Leu His Gly Phe Pro Leu Ser
                405                 410                 415     
Pro Leu Pro Pro Pro Lys Val Ser Leu Ser His Gln Met Arg Ser Leu
            420                 425                 430         
Glu Gln Gly Val Arg Gly Cys Tyr Cys Phe Leu Arg Phe Lys Cys Pro
        435                 440                 445             
Leu Ser Val Cys Cys Ser Gln Ala Val Thr Ser His Arg Ser Thr Ala
    450                 455                 460                 
Gly Asp His Met Ser Asn Cys Leu His Gly Cys Cys Ser Lys
465                 470                 475             


<210> 2075
<211> 2319
<212> PRT
<213> Homo sapiens

<400> 2075
Met Leu Thr Met Ser Val Thr Leu Ser Pro Leu Arg Ser Gln Asp Leu
 1               5                  10                  15      
Asp Pro Met Ala Thr Asp Ala Ser Pro Met Ala Ile Asn Met Thr Pro
            20                  25                  30          
Thr Val Glu Gln Gly Glu Gly Glu Glu Ala Met Lys Asp Met Asp Ser
        35                  40                  45              
Asp Gln Gln Tyr Glu Lys Pro Pro Pro Leu His Thr Gly Ala Asp Trp
    50                  55                  60                  
Lys Ile Val Leu His Leu Pro Glu Ile Glu Thr Trp Leu Arg Met Thr
65                  70                  75                  80  
Ser Glu Arg Val Arg Asp Leu Thr Tyr Ser Val Gln Gln Asp Ser Asp
                85                  90                  95      
Ser Lys His Val Asp Val His Leu Val Gln Leu Lys Asp Ile Cys Glu
            100                 105                 110         
Asp Ile Ser Asp His Val Glu Gln Ile His Ala Leu Leu Glu Thr Glu
        115                 120                 125             
Phe Ser Leu Lys Leu Leu Ser Tyr Ser Val Asn Val Ile Val Asp Ile
    130                 135                 140                 
His Ala Val Gln Leu Leu Trp His Gln Leu Arg Val Ser Val Leu Val
145                 150                 155                 160 
Leu Arg Glu Arg Ile Leu Gln Gly Leu Gln Asp Ala Asn Gly Asn Tyr
                165                 170                 175     
Thr Arg Gln Thr Asp Ile Leu Gln Ala Phe Ser Glu Glu Thr Lys Glu
            180                 185                 190         
Gly Arg Leu Asp Ser Leu Thr Glu Val Asp Asp Ser Gly Gln Leu Thr
        195                 200                 205             
Ile Lys Cys Ser Gln Asn Tyr Leu Ser Leu Asp Cys Gly Ile Thr Ala
    210                 215                 220                 
Phe Glu Leu Ser Asp Tyr Ser Pro Ser Glu Asp Leu Leu Ser Gly Leu
225                 230                 235                 240 
Gly Asp Met Thr Ser Ser Gln Val Lys Thr Lys Pro Phe Asp Ser Trp
                245                 250                 255     
Ser Tyr Ser Glu Met Glu Lys Glu Phe Pro Glu Leu Ile Arg Ser Val
            260                 265                 270         
Gly Leu Leu Thr Val Ala Ala Asp Ser Ile Ser Thr Asn Gly Ser Glu
        275                 280                 285             
Ala Val Thr Glu Glu Val Ser Gln Val Ser Leu Ser Val Asp Asp Lys
    290                 295                 300                 
Gly Gly Cys Glu Glu Asp Asn Ala Ser Ala Val Glu Glu Gln Pro Gly
305                 310                 315                 320 
Leu Thr Leu Gly Val Ser Ser Ser Ser Gly Glu Ala Leu Thr Asn Ala
                325                 330                 335     
Ala Gln Pro Ser Ser Glu Thr Val Gln Gln Glu Ser Ser Ser Ser Ser
            340                 345                 350         
His His Asp Ala Lys Asn Gln Gln Pro Val Pro Cys Glu Asn Ala Thr
        355                 360                 365             
Pro Lys Arg Thr Ile Arg Asp Cys Phe Asn Tyr Asn Glu Asp Ser Pro
    370                 375                 380                 
Thr Gln Pro Thr Leu Pro Lys Arg Gly Leu Phe Leu Lys Glu Glu Thr
385                 390                 395                 400 
Phe Lys Asn Asp Leu Lys Gly Asn Gly Gly Lys Arg Gln Met Val Asp
                405                 410                 415     
Leu Lys Pro Glu Met Ser Arg Ser Thr Pro Ser Leu Val Asp Pro Pro
            420                 425                 430         
Asp Arg Ser Lys Leu Cys Leu Val Leu Gln Ser Ser Tyr Pro Asn Ser
        435                 440                 445             
Pro Ser Ala Ala Ser Gln Ser Tyr Glu Cys Leu His Lys Val Gly Asn
    450                 455                 460                 
Gly Asn Leu Glu Asn Thr Val Lys Phe His Ile Lys Glu Ile Ser Ser
465                 470                 475                 480 
Ser Leu Gly Arg Leu Asn Asp Cys Tyr Lys Glu Lys Ser Arg Leu Lys
                485                 490                 495     
Lys Pro His Lys Thr Ser Glu Glu Val Pro Pro Cys Arg Thr Pro Lys
            500                 505                 510         
Arg Gly Thr Gly Ser Gly Lys Gln Ala Lys Asn Thr Lys Ser Ser Ala
        515                 520                 525             
Val Pro Asn Gly Glu Leu Ser Tyr Thr Ser Lys Ala Ile Glu Gly Pro
    530                 535                 540                 
Gln Thr Asn Ser Ala Ser Thr Ser Ser Leu Glu Pro Cys Asn Gln Arg
545                 550                 555                 560 
Ser Trp Asn Ala Lys Leu Gln Leu Gln Ser Glu Thr Ser Ser Ser Pro
                565                 570                 575     
Ala Phe Thr Gln Ser Ser Glu Ser Ser Val Gly Ser Asp Asn Ile Met
            580                 585                 590         
Ser Pro Val Pro Leu Leu Ser Lys His Lys Ser Lys Lys Gly Gln Ala
        595                 600                 605             
Ser Ser Pro Ser His Val Thr Arg Asn Gly Glu Val Val Glu Ala Trp
    610                 615                 620                 
Tyr Gly Ser Asp Glu Tyr Leu Ala Leu Pro Ser His Leu Lys Gln Thr
625                 630                 635                 640 
Glu Val Leu Ala Leu Lys Leu Glu Asn Leu Thr Lys Leu Leu Pro Gln
                645                 650                 655     
Lys Pro Arg Gly Glu Thr Ile Gln Asn Ile Asp Asp Trp Glu Leu Ser
            660                 665                 670         
Glu Met Asn Ser Asp Ser Glu Ile Tyr Pro Thr Tyr His Val Lys Lys
        675                 680                 685             
Lys His Thr Arg Leu Gly Arg Val Ser Pro Ser Ser Ser Ser Asp Ile
    690                 695                 700                 
Ala Ser Ser Leu Gly Glu Ser Ile Glu Ser Gly Pro Leu Ser Asp Ile
705                 710                 715                 720 
Leu Ser Asp Glu Glu Ser Ser Met Pro Leu Ala Gly Met Lys Lys Tyr
                725                 730                 735     
Ala Asp Glu Lys Ser Glu Arg Ala Ser Ser Ser Glu Lys Asn Glu Ser
            740                 745                 750         
His Ser Ala Thr Lys Ser Ala Leu Ile Gln Lys Leu Met Gln Asp Ile
        755                 760                 765             
Gln His Gln Asp Asn Tyr Glu Ala Ile Trp Glu Lys Ile Glu Gly Phe
    770                 775                 780                 
Val Asn Lys Leu Asp Glu Phe Ile Gln Trp Leu Asn Glu Ala Met Glu
785                 790                 795                 800 
Thr Thr Glu Asn Trp Thr Pro Pro Lys Ala Glu Met Asp Asp Leu Lys
                805                 810                 815     
Leu Tyr Leu Glu Thr His Leu Ser Phe Lys Leu Asn Val Asp Ser His
            820                 825                 830         
Cys Ala Leu Lys Glu Ala Val Glu Glu Glu Gly His Gln Leu Leu Glu
        835                 840                 845             
Leu Ile Ala Ser His Lys Ala Gly Leu Lys Asp Met Leu Arg Met Ile
    850                 855                 860                 
Ala Ser Gln Trp Lys Glu Leu Gln Arg Gln Ile Lys Arg Gln His Ser
865                 870                 875                 880 
Trp Ile Leu Arg Ala Leu Asp Thr Ile Lys Ala Glu Ile Leu Ala Thr
                885                 890                 895     
Asp Val Ser Val Glu Asp Glu Glu Gly Thr Gly Ser Pro Lys Ala Glu
            900                 905                 910         
Val Gln Leu Cys Tyr Leu Glu Ala Gln Arg Asp Ala Val Glu Gln Met
        915                 920                 925             
Ser Leu Lys Leu Tyr Ser Glu Gln Tyr Thr Ser Ser Ser Lys Arg Lys
    930                 935                 940                 
Glu Glu Phe Ala Asp Met Ser Lys Val His Ser Val Gly Ser Asn Gly
945                 950                 955                 960 
Leu Leu Asp Phe Asp Ser Glu Tyr Gln Glu Leu Trp Asp Trp Leu Ile
                965                 970                 975     
Asp Met Glu Ser Leu Val Met Asp Ser His Asp Leu Met Met Ser Glu
            980                 985                 990         
Glu Gln Gln Gln His Leu Tyr Lys Arg Tyr Ser Val Glu Met Ser Ile
        995                 1000                1005            
Arg His Leu Lys Lys Thr Glu Leu Leu Ser Lys Val Glu Ala Leu Lys
    1010                1015                1020                
Lys Gly Gly Val Leu Leu Pro Asn Asp Leu Leu Glu Lys Val Asp Ser
1025                1030                1035                1040
Ile Asn Glu Lys Trp Glu Leu Leu Gly Lys Thr Leu Gly Glu Lys Ile
                1045                1050                1055    
Gln Asp Thr Met Ala Gly His Ser Gly Ser Ser Pro Arg Asp Leu Leu
            1060                1065                1070        
Ser Pro Glu Ser Gly Ser Leu Val Arg Gln Leu Glu Val Arg Ile Lys
        1075                1080                1085            
Glu Leu Lys Gly Trp Leu Arg Asp Thr Glu Leu Phe Ile Phe Asn Ser
    1090                1095                1100                
Cys Leu Arg Gln Glu Lys Glu Gly Thr Met Asn Thr Glu Lys Gln Leu
1105                1110                1115                1120
Gln Tyr Phe Lys Ser Leu Cys Arg Glu Ile Lys Gln Arg Arg Arg Gly
                1125                1130                1135    
Val Ala Ser Ile Leu Arg Leu Cys Gln His Leu Leu Asp Asp Arg Glu
            1140                1145                1150        
Thr Cys Asn Leu Asn Ala Asp His Gln Pro Met Gln Leu Ile Ile Val
        1155                1160                1165            
Asn Leu Glu Arg Arg Trp Glu Ala Ile Val Met Gln Ala Val Gln Trp
    1170                1175                1180                
Gln Thr Arg Leu Gln Lys Lys Met Gly Lys Glu Ser Glu Thr Leu Asn
1185                1190                1195                1200
Val Ile Asp Pro Gly Leu Met Asp Leu Asn Gly Met Ser Glu Asp Ala
                1205                1210                1215    
Leu Glu Trp Asp Glu Met Asp Ile Ser Asn Lys Leu Ile Ser Leu Asn
            1220                1225                1230        
Glu Glu Ser Asn Asp Leu Asp Gln Glu Leu Gln Pro Val Ile Pro Ser
        1235                1240                1245            
Leu Lys Leu Gly Glu Thr Ser Asn Glu Asp Pro Gly Tyr Asp Glu Glu
    1250                1255                1260                
Ala Asp Asn His Gly Gly Ser Gln Tyr Ala Ser Asn Ile Thr Ala Pro
1265                1270                1275                1280
Ser Ser Pro His Ile Tyr Gln Val Tyr Ser Leu His Asn Val Glu Leu
                1285                1290                1295    
Tyr Glu Asp Asn His Met Pro Phe Leu Lys Asn Asn Pro Lys Val Thr
            1300                1305                1310        
Gly Met Thr Gln Pro Asn Val Leu Thr Lys Ser Leu Ser Lys Asp Ser
        1315                1320                1325            
Ser Phe Ser Ser Thr Lys Ser Leu Pro Asp Leu Leu Gly Gly Ser Asn
    1330                1335                1340                
Leu Val Lys Pro Cys Ala Cys His Gly Gly Asp Met Ser Gln Asn Ser
1345                1350                1355                1360
Gly Ser Glu Ser Gly Ile Val Ser Glu Gly Asp Thr Glu Thr Thr Thr
                1365                1370                1375    
Asn Ser Glu Met Cys Leu Leu Asn Ala Val Asp Gly Ser Pro Ser Asn
            1380                1385                1390        
Leu Glu Thr Glu His Leu Asp Pro Gln Met Gly Asp Ala Val Asn Val
        1395                1400                1405            
Leu Lys Gln Lys Phe Thr Asp Glu Gly Glu Ser Ile Lys Leu Pro Asn
    1410                1415                1420                
Ser Ser Gln Ser Ser Ile Ser Pro Val Gly Cys Val Asn Gly Lys Val
1425                1430                1435                1440
Gly Asp Leu Asn Ser Ile Thr Lys His Thr Pro Asp Cys Leu Gly Glu
                1445                1450                1455    
Glu Leu Gln Gly Lys His Asp Val Phe Thr Phe Tyr Asp Tyr Ser Tyr
            1460                1465                1470        
Leu Gln Gly Ser Lys Leu Lys Leu Pro Met Ile Met Lys Gln Ser Gln
        1475                1480                1485            
Ser Glu Lys Ala His Val Glu Asp Pro Leu Leu Arg Gly Phe Tyr Phe
    1490                1495                1500                
Asp Lys Lys Ser Cys Lys Ser Lys His Gln Thr Thr Glu Leu Gln Pro
1505                1510                1515                1520
Asp Val Pro Pro His Glu Arg Ile Leu Ala Ser Ala Ser His Glu Met
                1525                1530                1535    
Asp Arg Ile Ser Tyr Lys Ser Gly Asn Ile Glu Lys Thr Phe Thr Gly
            1540                1545                1550        
Met Gln Asn Ala Lys Gln Leu Ser Leu Leu Ser His Ser Ser Ser Ile
        1555                1560                1565            
Glu Ser Leu Ser Pro Gly Gly Asp Leu Phe Gly Leu Gly Ile Phe Lys
    1570                1575                1580                
Asn Gly Ser Asp Ser Leu Gln Arg Ser Thr Ser Leu Glu Ser Trp Leu
1585                1590                1595                1600
Thr Ser Tyr Lys Ser Asn Glu Asp Leu Phe Ser Cys His Ser Ser Gly
                1605                1610                1615    
Asp Ile Ser Val Ser Ser Gly Ser Val Gly Glu Leu Ser Lys Arg Thr
            1620                1625                1630        
Leu Asp Leu Leu Asn Arg Leu Glu Asn Ile Gln Ser Pro Ser Glu Gln
        1635                1640                1645            
Lys Ile Lys Arg Ser Val Ser Asp Ile Thr Leu Gln Ser Ser Ser Gln
    1650                1655                1660                
Lys Met Ser Phe Thr Gly Gln Met Ser Leu Asp Ile Ala Ser Ser Ile
1665                1670                1675                1680
Asn Glu Asp Ser Ala Ala Ser Leu Thr Glu Leu Ser Ser Ser Asp Glu
                1685                1690                1695    
Leu Ser Leu Cys Ser Glu Asp Ile Val Leu His Lys Asn Lys Ile Pro
            1700                1705                1710        
Glu Ser Asn Ala Ser Phe Arg Lys Arg Leu Thr Arg Ser Val Ala Asp
        1715                1720                1725            
Glu Ser Asp Val Asn Val Ser Met Ile Val Asn Val Ser Cys Thr Ser
    1730                1735                1740                
Ala Cys Thr Asp Asp Glu Asp Asp Ser Asp Leu Leu Ser Ser Ser Thr
1745                1750                1755                1760
Leu Thr Leu Thr Glu Glu Glu Leu Cys Ile Lys Asp Glu Asp Asp Asp
                1765                1770                1775    
Ser Ser Ile Ala Thr Asp Asp Glu Ile Tyr Glu Asp Cys Thr Leu Met
            1780                1785                1790        
Ser Gly Leu Asp Tyr Ile Lys Asn Glu Leu Gln Thr Trp Ile Arg Pro
        1795                1800                1805            
Lys Leu Ser Leu Thr Arg Asp Lys Lys Arg Cys Asn Val Ser Asp Glu
    1810                1815                1820                
Met Lys Gly Ser Lys Asp Ile Ser Ser Ser Glu Met Thr Asn Pro Ser
1825                1830                1835                1840
Asp Thr Leu Asn Ile Glu Thr Leu Leu Asn Gly Ser Val Lys Arg Val
                1845                1850                1855    
Ser Glu Asn Asn Gly Asn Gly Lys Asn Ser Ser His Thr His Glu Leu
            1860                1865                1870        
Gly Thr Lys Arg Glu Asn Lys Lys Thr Ile Phe Lys Val Asn Lys Asp
        1875                1880                1885            
Pro Tyr Val Ala Asp Met Glu Asn Gly Asn Ile Glu Gly Ile Pro Glu
    1890                1895                1900                
Arg Gln Lys Gly Lys Pro Asn Val Thr Ser Lys Val Ser Glu Asn Leu
1905                1910                1915                1920
Gly Ser His Gly Lys Glu Ile Ser Glu Ser Glu His Cys Lys Cys Lys
                1925                1930                1935    
Ala Leu Met Asp Ser Leu Asp Asp Ser Asn Thr Ala Gly Lys Glu Phe
            1940                1945                1950        
Val Ser Gln Asp Val Arg His Leu Pro Lys Lys Cys Pro Asn His His
        1955                1960                1965            
His Phe Glu Asn Gln Ser Thr Ala Ser Thr Pro Thr Glu Lys Ser Phe
    1970                1975                1980                
Ser Glu Leu Ala Leu Glu Thr Arg Phe Asn Asn Arg Gln Asp Ser Asp
1985                1990                1995                2000
Ala Leu Lys Ser Ser Asp Asp Ala Pro Ser Met Ala Gly Lys Ser Ala
                2005                2010                2015    
Gly Cys Cys Leu Ala Leu Glu Gln Asn Gly Thr Glu Glu Asn Ala Ser
            2020                2025                2030        
Ile Ser Asn Ile Ser Cys Cys Asn Cys Glu Pro Asp Val Phe His Gln
        2035                2040                2045            
Lys Asp Ala Glu Asp Cys Ser Val His Asn Phe Val Lys Glu Ile Ile
    2050                2055                2060                
Asp Met Ala Ser Thr Ala Leu Lys Ser Lys Ser Gln Pro Glu Asn Glu
2065                2070                2075                2080
Val Ala Ala Pro Thr Ser Leu Thr Gln Ile Lys Glu Lys Val Leu Glu
                2085                2090                2095    
His Ser His Arg Pro Ile Gln Leu Arg Lys Gly Asp Phe Tyr Ser Tyr
            2100                2105                2110        
Leu Ser Leu Ser Ser His Asp Ser Asp Cys Gly Glu Val Thr Asn Tyr
        2115                2120                2125            
Ile Glu Glu Lys Ser Ser Thr Pro Leu Pro Leu Asp Thr Thr Asp Ser
    2130                2135                2140                
Gly Leu Asp Asp Lys Glu Asp Ile Glu Cys Phe Phe Glu Ala Cys Val
2145                2150                2155                2160
Glu Gly Asp Ser Asp Gly Glu Glu Pro Cys Phe Ser Ser Ala Pro Pro
                2165                2170                2175    
Asn Glu Ser Ala Val Pro Ser Glu Ala Ala Met Pro Leu Gln Ala Thr
            2180                2185                2190        
Ala Cys Ser Ser Glu Phe Ser Asp Ser Ser Leu Ser Ala Asp Asp Ala
        2195                2200                2205            
Asp Thr Val Ala Leu Ser Ser Pro Ser Ser Gln Glu Arg Ala Glu Val
    2210                2215                2220                
Gly Lys Glu Val Asn Gly Leu Pro Gln Thr Ser Ser Gly Cys Ala Glu
2225                2230                2235                2240
Asn Leu Glu Phe Thr Pro Ser Lys Leu Asp Ser Glu Lys Glu Ser Ser
                2245                2250                2255    
Gly Lys Pro Gly Glu Ser Gly Met Pro Glu Glu His Asn Ala Ala Ser
            2260                2265                2270        
Ala Lys Ser Lys Val Gln Asp Leu Ser Leu Lys Ala Asn Gln Pro Thr
        2275                2280                2285            
Asp Lys Ala Ala Leu His Pro Ser Pro Lys Thr Leu Thr Cys Glu Glu
    2290                2295                2300                
Asn Leu Leu Asn Leu His Glu Lys Arg His Arg Asn Met His Arg
2305                2310                2315                


<210> 2076
<211> 161
<212> PRT
<213> Homo sapiens

<400> 2076
Met Ala Arg Ala Val Phe Gly Val Lys Cys Phe Ser Tyr Ser Thr Ser
 1               5                  10                  15      
Leu Ile Gly Leu Thr Phe Leu Pro Tyr Ile Phe Thr Gln Asn Asn Ala
            20                  25                  30          
Ile Ser Glu Ser Val Pro Leu Pro Ile Gln Ile Ile Phe Tyr Gly Ile
        35                  40                  45              
Met Gly Ser Phe Thr Val Ile Thr Pro Val Leu Leu His Phe Ile Thr
    50                  55                  60                  
Lys Gly Tyr Val Ile Arg Leu Tyr His Glu Ala Thr Thr Asp Thr Tyr
65                  70                  75                  80  
Lys Ala Ile Thr Tyr Asn Ala Met Leu Ala Glu Thr Ser Thr Val Phe
                85                  90                  95      
His Gln Asn Asp Val Lys Ile Pro Asp Ala Lys His Val Phe Thr Thr
            100                 105                 110         
Phe Tyr Ala Lys Thr Lys Ser Leu Leu Val Asn Pro Val Leu Phe Pro
        115                 120                 125             
Asn Arg Glu Asp Tyr Ile His Leu Met Gly Tyr Asp Lys Glu Glu Phe
    130                 135                 140                 
Ile Leu Tyr Met Glu Glu Thr Ser Glu Glu Lys Arg His Lys Asp Asp
145                 150                 155                 160 
Lys
    


<210> 2077
<211> 314
<212> PRT
<213> Homo sapiens

<400> 2077
Met Glu Asp Lys Arg Asn Ile Gln Ile Ile Glu Trp Glu His Leu Asp
 1               5                  10                  15      
Lys Lys Lys Phe Tyr Val Phe Gly Val Ala Met Thr Met Met Ile Arg
            20                  25                  30          
Val Ser Val Tyr Pro Phe Thr Leu Ile Arg Thr Arg Leu Gln Val Gln
        35                  40                  45              
Lys Gly Lys Ser Leu Tyr His Gly Thr Phe Asp Ala Phe Ile Lys Ile
    50                  55                  60                  
Leu Arg Ala Asp Gly Ile Thr Gly Leu Tyr Arg Gly Phe Leu Val Asn
65                  70                  75                  80  
Thr Phe Thr Leu Ile Ser Gly Gln Cys Tyr Val Thr Thr Tyr Glu Leu
                85                  90                  95      
Thr Arg Lys Phe Val Ala Asp Tyr Ser Gln Ser Asn Thr Val Lys Ser
            100                 105                 110         
Leu Val Ala Gly Gly Ser Ala Ser Leu Val Ala Gln Ser Ile Thr Val
        115                 120                 125             
Pro Ile Asp Val Val Ser Gln His Leu Met Met Gln Arg Lys Gly Glu
    130                 135                 140                 
Lys Met Gly Arg Phe Gln Val Arg Gly Asn Pro Glu Gly Gln Gly Val
145                 150                 155                 160 
Val Ala Phe Gly Gln Thr Lys Asp Ile Ile Arg Gln Ile Leu Gln Ala
                165                 170                 175     
Asp Gly Leu Arg Gly Phe Tyr Arg Gly Tyr Val Ala Ser Leu Leu Thr
            180                 185                 190         
Tyr Ile Pro Asn Ser Ala Val Trp Trp Pro Phe Tyr His Phe Tyr Ala
        195                 200                 205             
Glu Gln Leu Ser Tyr Leu Cys Pro Lys Glu Cys Pro His Ile Val Phe
    210                 215                 220                 
Gln Ala Val Ser Gly Pro Leu Ala Ala Ala Thr Ala Ser Ile Leu Thr
225                 230                 235                 240 
Asn Pro Met Asp Val Ile Arg Thr Arg Val Gln Val Glu Gly Lys Asn
                245                 250                 255     
Ser Ile Ile Leu Thr Phe Arg Gln Leu Met Ala Glu Glu Gly Pro Trp
            260                 265                 270         
Gly Leu Met Lys Gly Leu Ser Ala Arg Ile Ile Ser Ala Thr Pro Ser
        275                 280                 285             
Thr Ile Val Ile Val Val Gly Tyr Glu Ser Leu Lys Lys Leu Ser Leu
    290                 295                 300                 
Arg Pro Glu Leu Val Asp Ser Arg His Trp
305                 310                 


<210> 2078
<211> 567
<212> PRT
<213> Homo sapiens

<400> 2078
Met Ser Gly Thr Lys Pro Asp Ile Leu Trp Ala Pro His His Val Asp
 1               5                  10                  15      
Arg Phe Val Val Cys Asp Ser Glu Leu Ser Leu Tyr His Val Glu Ser
            20                  25                  30          
Thr Val Asn Ser Glu Leu Lys Ala Gly Ser Leu Arg Leu Ser Glu Asp
        35                  40                  45              
Ser Ala Ala Thr Leu Leu Ser Ile Asn Ser Asp Thr Pro Tyr Met Lys
    50                  55                  60                  
Cys Val Ala Trp Tyr Leu Asn Tyr Asp Pro Glu Cys Leu Leu Ala Val
65                  70                  75                  80  
Gly Gln Ala Asn Gly Arg Val Val Leu Thr Ser Leu Gly Gln Asp His
                85                  90                  95      
Asn Ser Lys Phe Lys Asp Leu Ile Gly Lys Glu Phe Val Pro Lys His
            100                 105                 110         
Ala Arg Gln Cys Asn Thr Leu Ala Trp Asn Pro Leu Asp Ser Asn Trp
        115                 120                 125             
Leu Ala Ala Gly Leu Asp Lys His Arg Ala Asp Phe Ser Val Leu Ile
    130                 135                 140                 
Trp Asp Ile Cys Ser Lys Tyr Thr Pro Asp Ile Val Pro Met Glu Lys
145                 150                 155                 160 
Val Lys Leu Ser Ala Gly Glu Thr Glu Thr Thr Leu Leu Val Thr Lys
                165                 170                 175     
Pro Leu Tyr Glu Leu Gly Gln Asn Asp Ala Cys Leu Ser Leu Cys Trp
            180                 185                 190         
Leu Pro Arg Asp Gln Lys Leu Leu Leu Ala Gly Met His Arg Asn Leu
        195                 200                 205             
Ala Ile Phe Asp Leu Arg Asn Thr Ser Gln Lys Met Phe Val Asn Thr
    210                 215                 220                 
Lys Ala Val Gln Gly Val Thr Val Asp Pro Tyr Phe His Asp Arg Val
225                 230                 235                 240 
Ala Ser Phe Tyr Glu Gly Gln Val Ala Ile Trp Asp Leu Arg Lys Phe
                245                 250                 255     
Glu Lys Pro Val Leu Thr Leu Thr Glu Gln Pro Lys Pro Leu Thr Lys
            260                 265                 270         
Val Ala Trp Cys Pro Thr Arg Thr Gly Leu Leu Ala Thr Leu Thr Arg
        275                 280                 285             
Asp Ser Asn Ile Ile Arg Leu Tyr Asp Met Gln His Thr Pro Thr Pro
    290                 295                 300                 
Ile Gly Asp Glu Thr Glu Pro Thr Ile Ile Glu Arg Ser Val Gln Pro
305                 310                 315                 320 
Cys Asp Asn Tyr Ile Ala Ser Phe Ala Trp His Pro Thr Ser Gln Asn
                325                 330                 335     
Arg Met Ile Val Val Thr Pro Asn Arg Thr Met Ser Asp Phe Thr Val
            340                 345                 350         
Phe Glu Arg Ile Ser Leu Ala Trp Ser Pro Ile Thr Ser Leu Met Trp
        355                 360                 365             
Ala Cys Gly Arg His Leu Tyr Glu Cys Thr Glu Glu Glu Asn Asp Asn
    370                 375                 380                 
Ser Leu Glu Lys Asp Ile Ala Thr Lys Met Arg Leu Arg Ala Leu Ser
385                 390                 395                 400 
Arg Tyr Gly Leu Asp Thr Glu Gln Val Trp Arg Asn His Ile Leu Ala
                405                 410                 415     
Gly Asn Glu Asp Pro Gln Leu Lys Ser Leu Trp Tyr Thr Leu His Tyr
            420                 425                 430         
Met Lys Gln Tyr Thr Glu Asp Met Asp Gln Lys Ser Pro Gly Asn Lys
        435                 440                 445             
Gly Ser Leu Val Tyr Ala Gly Ile Lys Ser Ile Val Lys Ser Ser Leu
    450                 455                 460                 
Gly Met Val Glu Ser Ser Arg His Asn Trp Ser Gly Leu Asp Lys Gln
465                 470                 475                 480 
Ser Asp Ile Gln Asn Leu Asn Glu Glu Arg Ile Leu Ala Leu Gln Leu
                485                 490                 495     
Cys Gly Trp Ile Lys Lys Gly Thr Asp Val Asp Val Gly Pro Phe Leu
            500                 505                 510         
Asn Ser Leu Val Gln Glu Gly Glu Trp Glu Arg Ala Ala Ala Val Ala
        515                 520                 525             
Leu Phe Asn Leu Asp Ile Arg Arg Ala Ile Gln Ile Leu Asn Glu Gly
    530                 535                 540                 
Ala Ser Ser Glu Lys Gly Arg Arg Ser Glu Ser Gln Cys Gly Ser Asn
545                 550                 555                 560 
Gly Phe Ile Gly Leu Tyr Gly
                565         


<210> 2079
<211> 664
<212> PRT
<213> Homo sapiens

<400> 2079
Met Glu Thr Pro Ser Gln Arg Arg Ala Thr Arg Ser Gly Ala Gln Ala
 1               5                  10                  15      
Ser Ser Thr Pro Leu Ser Pro Thr Arg Ile Thr Arg Leu Gln Glu Lys
            20                  25                  30          
Glu Asp Leu Gln Glu Leu Asn Asp Arg Leu Ala Val Tyr Ile Asp Arg
        35                  40                  45              
Val Arg Ser Leu Glu Thr Glu Asn Ala Gly Leu Arg Leu Arg Ile Thr
    50                  55                  60                  
Glu Ser Glu Glu Val Val Ser Arg Glu Val Ser Gly Ile Lys Ala Ala
65                  70                  75                  80  
Tyr Glu Ala Glu Leu Gly Asp Ala Arg Lys Thr Leu Asp Ser Val Ala
                85                  90                  95      
Lys Glu Arg Ala Arg Leu Gln Leu Glu Leu Ser Lys Val Arg Glu Glu
            100                 105                 110         
Phe Lys Glu Leu Lys Ala Arg Asn Thr Lys Lys Glu Gly Asp Leu Ile
        115                 120                 125             
Ala Ala Gln Ala Arg Leu Lys Asp Leu Glu Ala Leu Leu Asn Ser Lys
    130                 135                 140                 
Glu Ala Ala Leu Ser Thr Ala Leu Ser Glu Lys Arg Thr Leu Glu Gly
145                 150                 155                 160 
Glu Leu His Asp Leu Arg Gly Gln Val Ala Lys Leu Glu Ala Ala Leu
                165                 170                 175     
Gly Glu Ala Lys Lys Gln Leu Gln Asp Glu Met Leu Arg Arg Val Asp
            180                 185                 190         
Ala Glu Asn Arg Leu Gln Thr Met Lys Glu Glu Leu Asp Phe Gln Lys
        195                 200                 205             
Asn Ile Tyr Ser Glu Glu Leu Arg Glu Thr Lys Arg Arg His Glu Thr
    210                 215                 220                 
Arg Leu Val Glu Ile Asp Asn Gly Lys Gln Arg Glu Phe Glu Ser Arg
225                 230                 235                 240 
Leu Ala Asp Ala Leu Gln Glu Leu Arg Ala Gln His Glu Asp Gln Val
                245                 250                 255     
Glu Gln Tyr Lys Lys Glu Leu Glu Lys Thr Tyr Ser Ala Lys Leu Asp
            260                 265                 270         
Asn Ala Arg Gln Ser Ala Glu Arg Asn Ser Asn Leu Val Gly Ala Ala
        275                 280                 285             
His Glu Glu Leu Gln Gln Ser Arg Ile Arg Ile Asp Ser Leu Ser Ala
    290                 295                 300                 
Gln Leu Ser Gln Leu Gln Lys Gln Leu Ala Ala Lys Glu Ala Lys Leu
305                 310                 315                 320 
Arg Asp Leu Glu Asp Ser Leu Ala Arg Glu Arg Asp Thr Ser Arg Arg
                325                 330                 335     
Leu Leu Ala Glu Lys Glu Arg Glu Met Ala Glu Met Arg Ala Arg Met
            340                 345                 350         
Gln Gln Gln Leu Asp Glu Tyr Gln Glu Leu Leu Asp Ile Lys Leu Ala
        355                 360                 365             
Leu Asp Met Glu Ile His Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu
    370                 375                 380                 
Glu Arg Leu Arg Leu Ser Pro Ser Pro Thr Ser Gln Arg Ser Arg Gly
385                 390                 395                 400 
Arg Ala Ser Ser His Ser Ser Gln Thr Gln Gly Gly Gly Ser Val Thr
                405                 410                 415     
Lys Lys Arg Lys Leu Glu Ser Thr Glu Ser Arg Ser Ser Phe Ser Gln
            420                 425                 430         
His Ala Arg Thr Ser Gly Arg Val Ala Val Glu Glu Val Asp Glu Glu
        435                 440                 445             
Gly Lys Phe Val Arg Leu Arg Asn Lys Ser Asn Glu Asp Gln Ser Met
    450                 455                 460                 
Gly Asn Trp Gln Ile Lys Arg Gln Asn Gly Asp Asp Pro Leu Leu Thr
465                 470                 475                 480 
Tyr Arg Phe Pro Pro Lys Phe Thr Leu Lys Ala Gly Gln Val Val Thr
                485                 490                 495     
Ile Trp Ala Ala Gly Ala Gly Ala Thr His Ser Pro Pro Thr Asp Leu
            500                 505                 510         
Val Trp Lys Ala Gln Asn Thr Trp Gly Cys Gly Asn Ser Leu Arg Thr
        515                 520                 525             
Ala Leu Ile Asn Ser Thr Gly Glu Glu Val Ala Met Arg Lys Leu Val
    530                 535                 540                 
Arg Ser Val Thr Val Val Glu Asp Asp Glu Asp Glu Asp Gly Asp Asp
545                 550                 555                 560 
Leu Leu His His His His Gly Ser His Cys Ser Ser Ser Gly Asp Pro
                565                 570                 575     
Ala Glu Tyr Asn Leu Arg Ser Arg Thr Val Leu Cys Gly Thr Cys Gly
            580                 585                 590         
Gln Pro Ala Asp Lys Ala Ser Ala Ser Gly Ser Gly Ala Gln Val Gly
        595                 600                 605             
Gly Pro Ile Ser Ser Gly Ser Ser Ala Ser Ser Val Thr Val Thr Arg
    610                 615                 620                 
Ser Tyr Arg Ser Val Gly Gly Ser Gly Gly Gly Ser Phe Gly Asp Asn
625                 630                 635                 640 
Leu Val Thr Arg Ser Tyr Leu Leu Gly Asn Ser Ser Pro Arg Thr Gln
                645                 650                 655     
Ser Pro Gln Asn Cys Ser Ile Met
            660                 


<210> 2080
<211> 106
<212> PRT
<213> Homo sapiens

<400> 2080
Met Lys Met Thr Lys Thr Ala Lys Lys Arg Lys Thr Lys Ala Ala Leu
 1               5                  10                  15      
Arg Val Glu Met Arg Ala Thr Thr Gln Glu Thr Gln Leu Gln Thr Cys
            20                  25                  30          
Arg Lys Pro Val Lys Gly Pro Asn Tyr His Asn Glu Cys Cys Ile Leu
        35                  40                  45              
Arg Glu Thr Thr Arg Arg Leu Tyr Val Trp Leu Ser Asn Ile Leu Gly
    50                  55                  60                  
Phe Asp Met Asn Gln His Ile Val Leu Val Val Ile Asp Arg Thr Pro
65                  70                  75                  80  
Val Cys Met Tyr Ile Ile His Ile Pro Leu Cys Cys Val Ser Gly Gly
                85                  90                  95      
Lys Asp Ile Leu Ala Phe Phe Lys Ser Tyr
            100                 105     


<210> 2081
<211> 806
<212> PRT
<213> Homo sapiens

<400> 2081
Met Arg Asn Arg Thr Leu Ser Val Glu Ser Leu Ile Asp Glu Glu Val
 1               5                  10                  15      
Ile Tyr Ser Glu Leu Met Ser Asp Phe Glu Met Asp Glu Lys Asp Phe
            20                  25                  30          
Ala Ala Asp Ser Trp Ser Leu Ala Val Asp Ser Ser Phe Leu Gln Gln
        35                  40                  45              
His Lys Lys Glu Val Met Lys Gln Gln Asp Val Ile Tyr Glu Leu Ile
    50                  55                  60                  
Gln Thr Glu Leu His His Val Arg Thr Leu Lys Ile Met Thr Arg Leu
65                  70                  75                  80  
Phe Arg Thr Gly Met Leu Glu Glu Leu His Leu Glu Pro Gly Val Val
                85                  90                  95      
Gln Gly Leu Phe Pro Cys Val Asp Glu Leu Ser Asp Ile His Thr Arg
            100                 105                 110         
Phe Leu Ser Gln Leu Leu Glu Arg Arg Arg Gln Ala Leu Cys Pro Gly
        115                 120                 125             
Ser Thr Arg Asn Phe Val Ile His Arg Leu Gly Asp Leu Leu Ile Ser
    130                 135                 140                 
Gln Phe Ser Gly Pro Ser Ala Glu Gln Met Cys Lys Thr Tyr Ser Glu
145                 150                 155                 160 
Phe Cys Ser Arg His Ser Lys Ala Leu Lys Leu Tyr Lys Glu Leu Tyr
                165                 170                 175     
Ala Arg Asp Lys Arg Phe Gln Gln Phe Ile Arg Lys Val Thr Arg Pro
            180                 185                 190         
Ala Val Leu Lys Arg His Gly Val Gln Glu Cys Ile Leu Leu Val Thr
        195                 200                 205             
Gln Arg Ile Thr Lys Tyr Pro Leu Leu Ile Ser Arg Ile Leu Gln His
    210                 215                 220                 
Ser His Gly Ile Glu Glu Glu Arg Gln Asp Leu Thr Thr Ala Leu Gly
225                 230                 235                 240 
Leu Val Lys Glu Leu Leu Ser Asn Val Asp Glu Gly Ile Tyr Gln Leu
                245                 250                 255     
Glu Lys Gly Ala Arg Leu Gln Glu Ile Tyr Asn Arg Met Asp Pro Arg
            260                 265                 270         
Ala Gln Thr Pro Val Pro Gly Lys Gly Pro Phe Gly Arg Glu Glu Leu
        275                 280                 285             
Leu Arg Arg Lys Leu Ile His Asp Gly Cys Leu Leu Trp Lys Thr Ala
    290                 295                 300                 
Thr Gly Arg Phe Lys Asp Val Leu Val Leu Leu Met Thr Asp Val Leu
305                 310                 315                 320 
Val Phe Leu Gln Glu Lys Asp Gln Lys Tyr Ile Phe Pro Thr Leu Asp
                325                 330                 335     
Lys Pro Ser Val Val Ser Leu Gln Asn Leu Ile Val Arg Asp Ile Ala
            340                 345                 350         
Asn Gln Glu Lys Gly Met Phe Leu Ile Ser Ala Ala Pro Pro Glu Met
        355                 360                 365             
Tyr Glu Val His Thr Ala Ser Arg Asp Asp Arg Ser Thr Trp Ile Arg
    370                 375                 380                 
Val Ile Gln Gln Ser Val Arg Thr Cys Pro Ser Arg Glu Asp Phe Pro
385                 390                 395                 400 
Leu Ile Glu Thr Glu Asp Glu Ala Tyr Leu Arg Arg Ile Lys Met Glu
                405                 410                 415     
Leu Gln Gln Lys Asp Arg Ala Leu Val Glu Leu Leu Arg Glu Lys Val
            420                 425                 430         
Gly Leu Phe Ala Glu Met Thr His Phe Gln Ala Glu Glu Asp Gly Gly
        435                 440                 445             
Ser Gly Met Ala Leu Pro Thr Leu Pro Arg Gly Leu Phe Arg Ser Glu
    450                 455                 460                 
Ser Leu Glu Ser Pro Arg Gly Glu Arg Leu Leu Gln Asp Ala Ile Arg
465                 470                 475                 480 
Glu Val Glu Gly Leu Lys Asp Leu Leu Val Gly Pro Gly Val Glu Leu
                485                 490                 495     
Leu Leu Thr Pro Arg Glu Pro Ala Leu Pro Leu Glu Pro Asp Ser Gly
            500                 505                 510         
Gly Asn Thr Ser Pro Gly Val Thr Ala Asn Gly Glu Ala Arg Thr Phe
        515                 520                 525             
Asn Gly Ser Ile Glu Leu Cys Arg Ala Asp Ser Asp Ser Ser Gln Arg
    530                 535                 540                 
Asp Arg Asn Gly Asn Gln Leu Arg Ser Pro Gln Glu Glu Ala Leu Gln
545                 550                 555                 560 
Arg Leu Val Asn Leu Tyr Gly Leu Leu His Gly Leu Gln Ala Ala Val
                565                 570                 575     
Ala Gln Gln Asp Thr Leu Met Glu Ala Arg Phe Pro Glu Gly Pro Glu
            580                 585                 590         
Arg Arg Glu Lys Leu Cys Arg Ala Asn Ser Arg Asp Gly Glu Ala Gly
        595                 600                 605             
Arg Ala Gly Ala Ala Pro Val Ala Pro Glu Lys Gln Ala Thr Glu Leu
    610                 615                 620                 
Ala Leu Leu Gln Arg Gln His Ala Leu Leu Gln Glu Glu Leu Arg Arg
625                 630                 635                 640 
Cys Arg Arg Leu Gly Glu Glu Arg Ala Thr Glu Ala Gly Ser Leu Glu
                645                 650                 655     
Ala Arg Leu Arg Glu Ser Glu Gln Ala Arg Ala Leu Leu Glu Arg Glu
            660                 665                 670         
Ala Glu Glu Ala Arg Arg Gln Leu Ala Ala Leu Gly Gln Thr Glu Pro
        675                 680                 685             
Leu Pro Ala Glu Ala Pro Trp Ala Arg Arg Pro Val Asp Pro Arg Arg
    690                 695                 700                 
Arg Ser Leu Pro Ala Gly Asp Ala Leu Tyr Leu Ser Phe Asn Pro Pro
705                 710                 715                 720 
Gln Pro Ser Arg Gly Thr Asp Arg Leu Asp Leu Pro Val Thr Thr Arg
                725                 730                 735     
Ser Val His Arg Asn Phe Glu Asp Arg Glu Arg Gln Glu Leu Gly Ser
            740                 745                 750         
Pro Glu Glu Arg Leu Gln Asp Ser Ser Asp Pro Asp Thr Gly Ser Glu
        755                 760                 765             
Glu Glu Gly Ser Ser Arg Leu Ser Pro Pro His Ser Pro Arg Asp Phe
    770                 775                 780                 
Thr Arg Met Gln Asp Ile Pro Glu Glu Thr Glu Ser Arg Asp Gly Glu
785                 790                 795                 800 
Ala Val Ala Ser Glu Ser
                805     


<210> 2082
<211> 531
<212> PRT
<213> Homo sapiens

<400> 2082
Met Ser Lys Pro His Ser Glu Ala Gly Thr Ala Phe Ile Gln Thr Gln
 1               5                  10                  15      
Gln Leu His Ala Ala Met Ala Asp Thr Phe Leu Glu His Met Cys Arg
            20                  25                  30          
Leu Asp Ile Asp Ser Pro Pro Ile Thr Ala Arg Asn Thr Gly Ile Ile
        35                  40                  45              
Cys Thr Ile Gly Pro Ala Ser Arg Ser Val Glu Thr Leu Lys Glu Met
    50                  55                  60                  
Ile Lys Ser Gly Met Asn Val Ala Arg Leu Asn Phe Ser His Gly Thr
65                  70                  75                  80  
His Glu Tyr His Ala Glu Thr Ile Lys Asn Val Arg Thr Ala Thr Glu
                85                  90                  95      
Ser Phe Ala Ser Asp Pro Ile Leu Tyr Arg Pro Val Ala Val Ala Leu
            100                 105                 110         
Asp Thr Lys Gly Pro Glu Ile Arg Thr Gly Leu Ile Lys Gly Ser Gly
        115                 120                 125             
Thr Ala Glu Val Glu Leu Lys Lys Gly Ala Thr Leu Lys Ile Thr Leu
    130                 135                 140                 
Asp Asn Ala Tyr Met Glu Lys Cys Asp Glu Asn Ile Leu Trp Leu Asp
145                 150                 155                 160 
Tyr Lys Asn Ile Cys Lys Val Val Glu Val Gly Ser Lys Ile Tyr Val
                165                 170                 175     
Asp Asp Gly Leu Ile Ser Leu Gln Val Lys Gln Lys Gly Ala Asp Phe
            180                 185                 190         
Leu Val Thr Glu Val Glu Asn Gly Gly Ser Leu Gly Ser Lys Lys Gly
        195                 200                 205             
Val Asn Leu Pro Gly Ala Ala Val Asp Leu Pro Ala Val Ser Glu Lys
    210                 215                 220                 
Asp Ile Gln Asp Leu Lys Phe Gly Val Glu Gln Asp Val Asp Met Val
225                 230                 235                 240 
Phe Ala Ser Phe Ile Arg Lys Ala Ser Asp Val His Glu Val Arg Lys
                245                 250                 255     
Val Leu Gly Glu Lys Gly Lys Asn Ile Lys Ile Ile Ser Lys Ile Glu
            260                 265                 270         
Asn His Glu Gly Val Arg Arg Phe Asp Glu Ile Leu Glu Ala Ser Asp
        275                 280                 285             
Gly Ile Met Val Ala Arg Gly Asp Leu Gly Ile Glu Ile Pro Ala Glu
    290                 295                 300                 
Lys Val Phe Leu Ala Gln Lys Met Met Ile Gly Arg Cys Asn Arg Ala
305                 310                 315                 320 
Gly Lys Pro Val Ile Cys Ala Thr Gln Met Leu Glu Ser Met Ile Lys
                325                 330                 335     
Lys Pro Arg Pro Thr Arg Ala Glu Gly Ser Asp Val Ala Asn Ala Val
            340                 345                 350         
Leu Asp Gly Ala Asp Cys Ile Met Leu Ser Gly Glu Thr Ala Lys Gly
        355                 360                 365             
Asp Tyr Pro Leu Glu Ala Val Arg Met Gln His Leu Ile Ala Arg Glu
    370                 375                 380                 
Ala Glu Ala Ala Ile Tyr His Leu Gln Leu Phe Glu Glu Leu Arg Arg
385                 390                 395                 400 
Leu Ala Pro Ile Thr Ser Asp Pro Thr Glu Ala Thr Ala Val Gly Ala
                405                 410                 415     
Val Glu Ala Ser Phe Lys Cys Cys Ser Gly Ala Ile Ile Val Leu Thr
            420                 425                 430         
Lys Ser Gly Arg Ser Ala His Gln Val Ala Arg Tyr Arg Pro Arg Ala
        435                 440                 445             
Pro Ile Ile Ala Val Thr Arg Asn Pro Gln Thr Ala Arg Gln Ala His
    450                 455                 460                 
Leu Tyr Arg Gly Ile Phe Pro Val Leu Cys Lys Asp Pro Val Gln Glu
465                 470                 475                 480 
Ala Trp Ala Glu Asp Val Asp Leu Arg Val Asn Phe Ala Met Asn Val
                485                 490                 495     
Gly Lys Ala Arg Gly Phe Phe Lys Lys Gly Asp Val Val Ile Val Leu
            500                 505                 510         
Thr Gly Trp Arg Pro Gly Ser Gly Phe Thr Asn Thr Met Arg Val Val
        515                 520                 525             
Pro Val Pro
    530     


<210> 2083
<211> 251
<212> PRT
<213> Homo sapiens

<400> 2083
Met Pro Arg Cys Pro Ala Gly Pro Pro Ser Gly Pro His Pro Gln Leu
 1               5                  10                  15      
Pro Leu Gln Glu Pro Glu Leu Ile Thr Ala Phe Pro Pro Arg Glu Ala
            20                  25                  30          
Pro Ser Glu Arg Arg Gly His Arg Ser Cys Ile Val Gly Gly Gln Ala
        35                  40                  45              
Gln Ala Ile Leu Ser Pro Ser Arg Gly Gln Leu Glu Arg Pro Lys Thr
    50                  55                  60                  
Leu Ser Val His Gln Gly Pro Lys Ile Gln Gly Asp Ala Ser Leu Cys
65                  70                  75                  80  
Pro Leu Ser Cys Pro Ser Pro Ser Tyr Leu His Pro Pro Gln Pro Gly
                85                  90                  95      
Leu Pro Val Gln Asn Ser Val Leu Leu Arg Thr Pro Thr Pro Arg Ala
            100                 105                 110         
Lys Asp Gln Gly Glu Glu Gln Pro Leu His Pro Gln Ala Arg Arg Leu
        115                 120                 125             
Arg Asn Ile Leu Arg Lys Val Gln Ile Ala Glu Thr Gln Pro Cys Pro
    130                 135                 140                 
Cys Leu Leu His Pro Ala Pro Asn Met Val Pro Lys Leu Pro Glu Ala
145                 150                 155                 160 
Lys Lys Leu Leu Ile Phe Lys Val Val Gly Ile Ser Leu Leu Met Thr
                165                 170                 175     
Lys Leu Leu Ser Asn Ser Thr Cys Pro Pro Gln Glu Gly Ala Val Pro
            180                 185                 190         
Cys Tyr Pro Cys Ser His Ser Gln His Thr Arg Thr Gln Pro Ala Pro
        195                 200                 205             
Pro Pro Pro Pro Cys Thr Ser Pro Leu Trp Ala Leu Ala Trp Asp Gln
    210                 215                 220                 
Val Arg Arg Ile Pro Lys Pro Phe Arg Pro Glu Ile Arg Ala Arg Ser
225                 230                 235                 240 
Ala Leu Ser His Leu Pro Ser Lys Asn Leu Ala
                245                 250     


<210> 2084
<211> 411
<212> PRT
<213> Homo sapiens

<400> 2084
Met Asn Cys Cys Ile Gly Leu Gly Glu Lys Ala Arg Gly Ser His Arg
 1               5                  10                  15      
Ala Ser Tyr Pro Ser Leu Ser Ala Leu Phe Thr Glu Ala Ser Ile Leu
            20                  25                  30          
Gly Phe Gly Ser Phe Ala Val Lys Ala Gln Trp Thr Glu Asp Cys Arg
        35                  40                  45              
Lys Ser Thr Tyr Pro Pro Ser Gly Pro Thr Tyr Arg Gly Ala Val Pro
    50                  55                  60                  
Trp Tyr Thr Ile Asn Leu Asp Leu Pro Pro Tyr Lys Arg Trp His Glu
65                  70                  75                  80  
Leu Met Leu Asp Lys Ala Pro Met Leu Lys Val Ile Val Asn Ser Leu
                85                  90                  95      
Lys Asn Met Ile Asn Thr Phe Val Pro Ser Gly Lys Val Met Gln Val
            100                 105                 110         
Val Asp Glu Lys Leu Pro Gly Leu Leu Gly Asn Phe Pro Gly Pro Phe
        115                 120                 125             
Glu Glu Glu Met Lys Gly Ile Ala Ala Val Thr Asp Ile Pro Leu Gly
    130                 135                 140                 
Glu Ile Ile Ser Phe Asn Ile Phe Tyr Glu Leu Phe Thr Ile Cys Thr
145                 150                 155                 160 
Ser Ile Val Ala Glu Asp Lys Lys Gly His Leu Ile His Gly Arg Asn
                165                 170                 175     
Met Asp Phe Gly Val Phe Leu Gly Trp Asn Ile Asn Asn Asp Thr Trp
            180                 185                 190         
Val Ile Thr Glu Gln Leu Lys Pro Leu Thr Val Asn Leu Asp Phe Gln
        195                 200                 205             
Arg Asn Asn Lys Thr Val Phe Lys Ala Ser Ser Phe Ala Gly Tyr Val
    210                 215                 220                 
Gly Met Leu Thr Gly Phe Lys Pro Gly Leu Phe Ser Leu Thr Leu Asn
225                 230                 235                 240 
Glu Arg Phe Ser Ile Asn Gly Gly Tyr Leu Gly Ile Leu Glu Trp Ile
                245                 250                 255     
Leu Gly Lys Lys Asp Ala Met Trp Ile Gly Phe Leu Thr Arg Thr Val
            260                 265                 270         
Leu Glu Asn Ser Thr Ser Tyr Glu Glu Ala Lys Asn Leu Leu Thr Lys
        275                 280                 285             
Thr Lys Ile Leu Ala Pro Ala Tyr Phe Ile Leu Gly Gly Asn Gln Ser
    290                 295                 300                 
Gly Glu Gly Cys Val Ile Thr Arg Asp Arg Lys Glu Ser Leu Asp Val
305                 310                 315                 320 
Tyr Glu Leu Asp Ala Lys Gln Gly Arg Trp Tyr Val Val Gln Thr Asn
                325                 330                 335     
Tyr Asp Arg Trp Lys His Pro Phe Phe Leu Asp Asp Arg Arg Thr Pro
            340                 345                 350         
Ala Lys Met Cys Leu Asn Arg Thr Ser Gln Glu Asn Ile Ser Phe Glu
        355                 360                 365             
Thr Met Tyr Asp Val Leu Ser Thr Lys Pro Val Leu Asn Lys Leu Thr
    370                 375                 380                 
Val Tyr Thr Thr Leu Ile Asp Val Thr Lys Gly Gln Phe Glu Thr Tyr
385                 390                 395                 400 
Leu Arg Asp Cys Pro Asp Pro Cys Ile Gly Trp
                405                 410     


<210> 2085
<211> 886
<212> PRT
<213> Homo sapiens

<400> 2085
Met Gly Gln Lys Leu Lys Gln Arg Leu Arg Leu Asp Val Gly Arg Glu
 1               5                  10                  15      
Ile Cys Arg Gln Tyr Pro Leu Phe Cys Phe Leu Leu Leu Cys Leu Ser
            20                  25                  30          
Ala Ala Ser Leu Leu Leu Asn Arg Tyr Ile His Ile Leu Met Ile Phe
        35                  40                  45              
Trp Ser Phe Val Ala Gly Val Val Thr Phe Tyr Cys Ser Leu Gly Pro
    50                  55                  60                  
Asp Ser Leu Leu Pro Asn Ile Phe Phe Thr Ile Lys Tyr Lys Pro Lys
65                  70                  75                  80  
Gln Leu Gly Leu Gln Glu Leu Phe Pro Gln Gly His Ser Cys Ala Val
                85                  90                  95      
Cys Gly Lys Val Lys Cys Lys Arg His Arg Pro Ser Leu Leu Leu Glu
            100                 105                 110         
Asn Tyr Gln Pro Trp Leu Asp Leu Lys Ile Ser Ser Lys Val Asp Ala
        115                 120                 125             
Ser Leu Ser Glu Val Asp Ile Pro Ser Ile Ile Thr Lys Lys Leu Leu
    130                 135                 140                 
Lys Ala Ala Met Lys His Ile Glu Val Ile Val Lys Ala Arg Gln Lys
145                 150                 155                 160 
Val Lys Asn Thr Glu Phe Leu Gln Gln Ala Ala Leu Glu Glu Tyr Gly
                165                 170                 175     
Pro Glu Leu His Val Ala Leu Arg Ser Arg Arg Asp Glu Leu His Tyr
            180                 185                 190         
Leu Arg Lys Leu Thr Glu Leu Leu Phe Pro Tyr Ile Leu Pro Pro Lys
        195                 200                 205             
Ala Thr Asp Cys Arg Ser Leu Thr Leu Leu Ile Arg Glu Ile Leu Ser
    210                 215                 220                 
Gly Ser Val Phe Leu Pro Ser Leu Asp Phe Leu Ala Asp Pro Asp Thr
225                 230                 235                 240 
Val Asn His Leu Leu Ile Ile Phe Ile Asp Asp Ser Pro Pro Glu Lys
                245                 250                 255     
Ala Thr Glu Pro Ala Ser Pro Leu Val Pro Phe Leu Gln Lys Phe Ala
            260                 265                 270         
Glu Pro Arg Asn Lys Lys Pro Ser Val Leu Lys Leu Glu Leu Lys Gln
        275                 280                 285             
Ile Arg Glu Gln Gln Asp Leu Leu Phe Arg Phe Met Asn Phe Leu Lys
    290                 295                 300                 
Gln Glu Gly Ala Val His Val Leu Gln Phe Cys Leu Thr Val Glu Glu
305                 310                 315                 320 
Phe Asn Asp Arg Ile Leu Arg Pro Glu Leu Ser Asn Asp Glu Met Leu
                325                 330                 335     
Ser Leu His Glu Glu Leu Gln Lys Ile Tyr Lys Thr Tyr Cys Leu Asp
            340                 345                 350         
Glu Ser Ile Asp Lys Ile Arg Phe Asp Pro Phe Ile Val Glu Glu Ile
        355                 360                 365             
Gln Arg Ile Ala Glu Gly Pro Tyr Ile Asp Val Val Lys Leu Gln Thr
    370                 375                 380                 
Met Arg Cys Leu Phe Glu Ala Tyr Glu His Val Leu Ser Leu Leu Glu
385                 390                 395                 400 
Asn Val Phe Thr Pro Met Phe Cys His Ser Asp Glu Tyr Phe Arg Gln
                405                 410                 415     
Leu Leu Arg Gly Ala Glu Ser Pro Thr Arg Asn Ser Lys Leu Asn Arg
            420                 425                 430         
Asn Thr Gln Lys Arg Gly Glu Ser Phe Gly Ile Ser Arg Ile Gly Ser
        435                 440                 445             
Lys Ile Lys Gly Val Phe Lys Ser Thr Thr Met Glu Gly Ala Met Leu
    450                 455                 460                 
Pro Asn Tyr Gly Val Ala Glu Gly Glu Asp Asp Phe Ile Glu Glu Gly
465                 470                 475                 480 
Ile Val Val Met Glu Asp Asp Ser Pro Val Glu Ala Val Ser Thr Pro
                485                 490                 495     
Asn Thr Pro Arg Asn Leu Ala Ala Trp Lys Ile Ser Ile Pro Tyr Val
            500                 505                 510         
Asp Phe Phe Glu Asp Pro Ser Ser Glu Arg Lys Glu Lys Lys Glu Arg
        515                 520                 525             
Ile Pro Val Phe Cys Ile Asp Val Glu Arg Asn Asp Arg Arg Ala Val
    530                 535                 540                 
Gly His Glu Pro Glu His Trp Ser Val Tyr Arg Arg Tyr Leu Glu Phe
545                 550                 555                 560 
Tyr Val Leu Glu Ser Lys Leu Thr Glu Phe His Gly Ala Phe Pro Asp
                565                 570                 575     
Ala Gln Leu Pro Ser Lys Arg Ile Ile Gly Pro Lys Asn Tyr Glu Phe
            580                 585                 590         
Leu Lys Ser Lys Arg Glu Glu Phe Gln Glu Tyr Leu Gln Lys Leu Leu
        595                 600                 605             
Gln His Pro Glu Leu Ser Asn Ser Gln Leu Leu Ala Asp Phe Leu Ser
    610                 615                 620                 
Pro Asn Gly Gly Glu Thr Gln Phe Leu Asp Lys Ile Leu Pro Asp Val
625                 630                 635                 640 
Asn Leu Gly Lys Ile Ile Lys Ser Val Pro Gly Lys Leu Met Lys Glu
                645                 650                 655     
Lys Gly Gln His Leu Glu Pro Phe Ile Met Asn Phe Ile Asn Ser Cys
            660                 665                 670         
Glu Ser Pro Lys Pro Lys Pro Ser Arg Pro Glu Leu Thr Ile Leu Ser
        675                 680                 685             
Pro Thr Ser Glu Asn Asn Lys Lys Leu Phe Asn Asp Leu Phe Lys Asn
    690                 695                 700                 
Asn Ala Asn Arg Ala Glu Asn Thr Glu Arg Lys Gln Asn Gln Asn Tyr
705                 710                 715                 720 
Phe Met Glu Val Met Thr Val Glu Gly Val Tyr Asp Tyr Leu Met Tyr
                725                 730                 735     
Val Gly Arg Val Val Phe Gln Val Pro Asp Trp Leu His His Leu Leu
            740                 745                 750         
Met Gly Thr Arg Ile Leu Phe Lys Asn Thr Leu Glu Met Tyr Thr Asp
        755                 760                 765             
Tyr Tyr Leu Gln Cys Lys Leu Glu Gln Leu Phe Gln Glu His Arg Leu
    770                 775                 780                 
Val Ser Leu Ile Thr Leu Leu Arg Asp Ala Ile Phe Cys Glu Asn Thr
785                 790                 795                 800 
Glu Pro Arg Ser Leu Gln Asp Lys Gln Lys Gly Ala Lys Gln Thr Phe
                805                 810                 815     
Glu Glu Met Met Asn Tyr Ile Pro Asp Leu Leu Val Lys Cys Ile Gly
            820                 825                 830         
Glu Glu Thr Lys Tyr Glu Ser Ile Arg Leu Leu Phe Asp Gly Leu Gln
        835                 840                 845             
Gln Pro Val Leu Asn Lys Gln Leu Thr Tyr Val Leu Leu Asp Ile Val
    850                 855                 860                 
Ile Gln Glu Leu Phe Pro Glu Leu Asn Lys Val Gln Lys Glu Val Thr
865                 870                 875                 880 
Ser Val Thr Ser Trp Met
                885     


<210> 2086
<211> 102
<212> PRT
<213> Homo sapiens

<400> 2086
Met Lys Ser His Pro Ser Arg Ala Gln Leu Thr Arg Val Ser Ala Ser
 1               5                  10                  15      
Ala Ser Gln Gln Arg Leu Asn Gln Glu Gln Pro Gln Glu Met Arg Gly
            20                  25                  30          
Arg Glu Cys Ser Gly Cys Arg Gly Val Val Arg Ser Pro Gly Glu Gly
        35                  40                  45              
Ile Glu Gly Gln Pro Lys Ser Lys Pro Val Trp Lys Pro Lys Gly Leu
    50                  55                  60                  
Cys Pro Ser Val Gln Glu Pro Gly Gly Ile Ala Glu Ser Pro Phe Ser
65                  70                  75                  80  
Gly Glu Ala Tyr Arg Pro Leu Arg Lys Thr Cys Ser Val Arg Ser Leu
                85                  90                  95      
Arg Ala Ser Ser His Ser
            100         


<210> 2087
<211> 289
<212> PRT
<213> Homo sapiens

<400> 2087
Met Glu Asn Gly Tyr Thr Tyr Glu Asp Tyr Lys Asn Thr Ala Glu Trp
 1               5                  10                  15      
Leu Leu Ser His Thr Lys His Arg Pro Gln Val Ala Ile Ile Cys Gly
            20                  25                  30          
Ser Gly Leu Gly Gly Leu Thr Asp Lys Leu Thr Gln Ala Gln Ile Phe
        35                  40                  45              
Asp Tyr Gly Glu Ile Pro Asn Phe Pro Arg Ser Thr Val Pro Gly His
    50                  55                  60                  
Ala Gly Arg Leu Val Phe Gly Phe Leu Asn Gly Arg Ala Cys Val Met
65                  70                  75                  80  
Met Gln Gly Arg Phe His Met Tyr Glu Gly Tyr Pro Leu Trp Lys Val
                85                  90                  95      
Thr Phe Pro Val Arg Val Phe His Leu Leu Gly Val Asp Thr Leu Val
            100                 105                 110         
Val Thr Asn Ala Ala Gly Gly Leu Asn Pro Lys Phe Glu Val Gly Asp
        115                 120                 125             
Ile Met Leu Ile Arg Asp His Ile Asn Leu Pro Gly Phe Ser Gly Gln
    130                 135                 140                 
Asn Pro Leu Arg Gly Pro Asn Asp Glu Arg Phe Gly Asp Arg Phe Pro
145                 150                 155                 160 
Ala Met Ser Asp Ala Tyr Asp Arg Thr Met Arg Gln Arg Ala Leu Ser
                165                 170                 175     
Thr Trp Lys Gln Met Gly Glu Gln Arg Glu Leu Gln Glu Gly Thr Tyr
            180                 185                 190         
Val Met Val Ala Gly Pro Ser Phe Glu Thr Val Ala Glu Cys Arg Val
        195                 200                 205             
Leu Gln Lys Leu Gly Ala Asp Ala Val Gly Met Ser Thr Val Pro Glu
    210                 215                 220                 
Val Ile Val Ala Arg His Cys Gly Leu Arg Val Phe Gly Phe Ser Leu
225                 230                 235                 240 
Ile Thr Asn Lys Val Ile Met Asp Tyr Glu Ser Leu Glu Lys Ala Asn
                245                 250                 255     
His Glu Glu Val Leu Ala Ala Gly Lys Gln Ala Ala Gln Lys Leu Glu
            260                 265                 270         
Gln Phe Val Ser Ile Leu Met Ala Ser Ile Pro Leu Pro Asp Lys Ala
        275                 280                 285             
Ser
    


<210> 2088
<211> 422
<212> PRT
<213> Homo sapiens

<400> 2088
Met Ala Ala Gln Gln Asn Pro Leu Gln Gln Pro Arg Gly Arg Arg Gly
 1               5                  10                  15      
Leu Gly Gln Arg Gly Ser Ser Arg Gln Gly Ser Pro Gly Ser Val Ser
            20                  25                  30          
Lys Gln Lys Pro Cys Asp Leu Pro Leu Arg Leu Leu Val Pro Thr Gln
        35                  40                  45              
Phe Val Gly Ala Ile Ile Gly Lys Glu Gly Ala Thr Ile Arg Asn Ile
    50                  55                  60                  
Thr Lys Gln Thr Gln Ser Lys Ile Asp Val His Arg Lys Glu Asn Ala
65                  70                  75                  80  
Gly Ala Ala Glu Lys Ser Ile Thr Ile Leu Ser Thr Pro Glu Gly Thr
                85                  90                  95      
Ser Ala Ala Cys Lys Ser Ile Leu Glu Ile Met His Lys Glu Ala Gln
            100                 105                 110         
Asp Ile Lys Phe Thr Glu Glu Ile Pro Leu Lys Ile Leu Ala His Asn
        115                 120                 125             
Asn Phe Val Gly Arg Leu Ile Gly Lys Glu Gly Arg Asn Leu Lys Lys
    130                 135                 140                 
Ile Glu Gln Asp Thr Asp Thr Lys Ile Thr Ile Ser Pro Leu Gln Glu
145                 150                 155                 160 
Leu Thr Leu Tyr Asn Pro Glu Arg Thr Ile Thr Val Lys Gly Asn Val
                165                 170                 175     
Glu Thr Cys Ala Lys Ala Glu Glu Glu Ile Met Lys Lys Ile Arg Glu
            180                 185                 190         
Ser Tyr Glu Asn Asp Ile Ala Ser Met Asn Leu Gln Ala His Leu Ile
        195                 200                 205             
Pro Gly Leu Asn Leu Asn Ala Leu Gly Leu Phe Pro Pro Thr Ser Gly
    210                 215                 220                 
Met Pro Pro Pro Thr Ser Gly Pro Pro Ser Ala Met Thr Pro Pro Tyr
225                 230                 235                 240 
Pro Gln Phe Glu Gln Ser Glu Thr Glu Thr Val His Leu Phe Ile Pro
                245                 250                 255     
Ala Leu Ser Val Gly Ala Ile Ile Gly Lys Gln Gly Gln His Ile Lys
            260                 265                 270         
Gln Leu Ser Arg Phe Ala Gly Ala Ser Ile Lys Ile Ala Pro Ala Glu
        275                 280                 285             
Ala Pro Asp Ala Lys Val Arg Met Val Ile Ile Thr Gly Pro Pro Glu
    290                 295                 300                 
Ala Gln Phe Lys Ala Gln Gly Arg Ile Tyr Gly Lys Ile Lys Glu Glu
305                 310                 315                 320 
Asn Phe Val Ser Pro Lys Glu Glu Val Lys Leu Glu Ala His Ile Arg
                325                 330                 335     
Val Pro Ser Phe Ala Ala Gly Arg Val Ile Gly Lys Gly Gly Lys Thr
            340                 345                 350         
Val Asn Glu Leu Gln Asn Leu Ser Ser Ala Glu Val Val Val Pro Arg
        355                 360                 365             
Asp Gln Thr Pro Asp Glu Asn Asp Gln Val Val Val Lys Ile Thr Gly
    370                 375                 380                 
His Phe Tyr Ala Cys Gln Val Ala Gln Arg Lys Ile Gln Glu Ile Leu
385                 390                 395                 400 
Thr Gln Val Lys Gln His Gln Gln Gln Lys Ala Leu Gln Ser Gly Pro
                405                 410                 415     
Pro Gln Ser Arg Arg Lys
            420         


<210> 2089
<211> 409
<212> PRT
<213> Homo sapiens

<400> 2089
Met Glu Val Asp Ile Leu Phe Gln Leu Ala Asp Leu Tyr Glu Pro Arg
 1               5                  10                  15      
Gly Arg Met Thr Leu Ala Asp Ile Glu Arg Ile Ala Pro Leu Glu Glu
            20                  25                  30          
Gly Thr Leu Pro Phe Asn Leu Ala Glu Ala Gln Arg Gln Lys Ala Ser
        35                  40                  45              
Gly Asp Ser Ala Arg Pro Val Leu Leu Gln Val Ala Glu Ser Ala Tyr
    50                  55                  60                  
Arg Phe Gly Leu Gly Ser Val Ala Gly Ala Val Gly Ala Thr Ala Val
65                  70                  75                  80  
Tyr Pro Ile Asp Leu Val Lys Thr Arg Met Gln Asn Gln Arg Ser Thr
                85                  90                  95      
Gly Ser Phe Val Gly Glu Leu Met Tyr Lys Asn Ser Phe Asp Cys Phe
            100                 105                 110         
Lys Lys Val Leu Arg Tyr Glu Gly Phe Phe Gly Leu Tyr Arg Gly Leu
        115                 120                 125             
Leu Pro Gln Leu Leu Gly Val Ala Pro Glu Lys Ala Ile Lys Leu Thr
    130                 135                 140                 
Val Asn Asp Phe Val Arg Asp Lys Phe Met His Lys Asp Gly Ser Val
145                 150                 155                 160 
Pro Leu Ala Ala Glu Ile Leu Ala Gly Gly Cys Ala Gly Gly Ser Gln
                165                 170                 175     
Val Ile Phe Thr Asn Pro Leu Glu Ile Val Lys Ile Arg Leu Gln Val
            180                 185                 190         
Ala Gly Glu Ile Thr Thr Gly Pro Arg Val Ser Ala Leu Ser Val Val
        195                 200                 205             
Arg Asp Leu Gly Phe Phe Gly Ile Tyr Lys Gly Ala Lys Ala Cys Phe
    210                 215                 220                 
Leu Arg Asp Ile Pro Phe Ser Ala Ile Tyr Phe Pro Cys Tyr Ala His
225                 230                 235                 240 
Val Lys Ala Ser Phe Ala Asn Glu Asp Gly Gln Val Ser Pro Gly Ser
                245                 250                 255     
Leu Leu Leu Ala Gly Ala Ile Ala Gly Met Pro Ala Ala Ser Leu Val
            260                 265                 270         
Thr Pro Ala Asp Val Ile Lys Thr Arg Leu Gln Val Ala Ala Arg Ala
        275                 280                 285             
Gly Gln Thr Thr Tyr Ser Gly Val Ile Asp Cys Phe Arg Lys Ile Leu
    290                 295                 300                 
Arg Glu Glu Gly Pro Lys Ala Leu Trp Lys Gly Ala Gly Ala Arg Val
305                 310                 315                 320 
Phe Arg Ser Ser Pro Gln Phe Gly Val Thr Leu Leu Thr Tyr Glu Leu
                325                 330                 335     
Leu Gln Arg Trp Phe Tyr Ile Asp Phe Gly Gly Val Lys Pro Met Gly
            340                 345                 350         
Ser Glu Pro Val Pro Lys Ser Arg Ile Asn Leu Pro Ala Pro Asn Pro
        355                 360                 365             
Asp His Val Gly Gly Tyr Lys Leu Ala Val Ala Thr Phe Ala Gly Ile
    370                 375                 380                 
Glu Asn Lys Phe Gly Leu Tyr Leu Pro Leu Phe Lys Pro Ser Val Ser
385                 390                 395                 400 
Thr Ser Lys Ala Ile Gly Gly Gly Pro
                405                 


<210> 2090
<211> 509
<212> PRT
<213> Homo sapiens

<400> 2090
Met Gln Ser Trp Ser Arg Val Tyr Cys Ser Leu Ala Lys Arg Gly His
 1               5                  10                  15      
Phe Asn Arg Ile Ser His Gly Leu Gln Gly Leu Ser Ala Val Pro Leu
            20                  25                  30          
Arg Thr Tyr Ala Asp Gln Pro Ile Asp Ala Asp Val Thr Val Ile Gly
        35                  40                  45              
Ser Gly Pro Gly Gly Tyr Val Ala Ala Ile Lys Ala Ala Gln Leu Gly
    50                  55                  60                  
Phe Lys Thr Val Cys Ile Glu Lys Asn Glu Thr Leu Gly Gly Thr Cys
65                  70                  75                  80  
Leu Asn Val Gly Cys Ile Pro Ser Lys Ala Leu Leu Asn Asn Ser His
                85                  90                  95      
Tyr Tyr His Met Ala His Gly Lys Asp Phe Ala Ser Arg Gly Ile Glu
            100                 105                 110         
Met Ser Glu Val Arg Leu Asn Leu Asp Lys Met Met Glu Gln Lys Ser
        115                 120                 125             
Thr Ala Val Lys Ala Leu Thr Gly Gly Ile Ala His Leu Phe Lys Gln
    130                 135                 140                 
Asn Lys Val Val His Val Asn Gly Tyr Gly Lys Ile Thr Gly Lys Asn
145                 150                 155                 160 
Gln Val Thr Ala Thr Lys Ala Asp Gly Gly Thr Gln Val Ile Asp Thr
                165                 170                 175     
Lys Asn Ile Leu Ile Ala Thr Gly Ser Glu Val Thr Pro Phe Pro Gly
            180                 185                 190         
Ile Thr Ile Asp Glu Asp Thr Ile Val Ser Ser Thr Gly Ala Leu Ser
        195                 200                 205             
Leu Lys Lys Val Pro Glu Lys Met Val Val Ile Gly Ala Gly Val Ile
    210                 215                 220                 
Gly Val Glu Leu Gly Ser Val Trp Gln Arg Leu Gly Ala Asp Val Thr
225                 230                 235                 240 
Ala Val Glu Phe Leu Gly His Val Gly Gly Val Gly Ile Asp Met Glu
                245                 250                 255     
Ile Ser Lys Asn Phe Gln Arg Ile Leu Gln Lys Gln Gly Phe Lys Phe
            260                 265                 270         
Lys Leu Asn Thr Lys Val Thr Gly Ala Thr Lys Lys Ser Asp Gly Lys
        275                 280                 285             
Ile Asp Val Ser Ile Glu Ala Ala Ser Gly Gly Lys Ala Glu Val Ile
    290                 295                 300                 
Thr Cys Asp Val Leu Leu Val Cys Ile Gly Arg Arg Pro Phe Thr Lys
305                 310                 315                 320 
Asn Leu Gly Leu Glu Glu Leu Gly Ile Glu Leu Asp Pro Arg Gly Arg
                325                 330                 335     
Ile Pro Val Asn Thr Arg Phe Gln Thr Lys Ile Pro Asn Ile Tyr Ala
            340                 345                 350         
Ile Gly Asp Val Val Ala Gly Pro Met Leu Ala His Lys Ala Glu Asp
        355                 360                 365             
Glu Gly Ile Ile Cys Val Glu Gly Met Ala Gly Gly Ala Val His Ile
    370                 375                 380                 
Asp Tyr Asn Cys Val Pro Ser Val Ile Tyr Thr His Pro Glu Val Ala
385                 390                 395                 400 
Trp Val Gly Lys Ser Glu Glu Gln Leu Lys Glu Glu Gly Ile Glu Tyr
                405                 410                 415     
Lys Val Gly Lys Phe Pro Phe Ala Ala Asn Ser Arg Ala Lys Thr Asn
            420                 425                 430         
Ala Asp Thr Asp Gly Met Val Lys Ile Leu Gly Gln Lys Ser Thr Asp
        435                 440                 445             
Arg Val Leu Gly Ala His Ile Leu Gly Pro Gly Ala Gly Glu Met Val
    450                 455                 460                 
Asn Glu Ala Ala Leu Ala Leu Glu Tyr Gly Ala Ser Cys Glu Asp Ile
465                 470                 475                 480 
Ala Arg Val Cys His Ala His Pro Thr Leu Ser Glu Ala Phe Arg Glu
                485                 490                 495     
Ala Asn Leu Ala Ala Ser Phe Gly Lys Ser Ile Asn Phe
            500                 505                 


<210> 2091
<211> 306
<212> PRT
<213> Homo sapiens

<400> 2091
Met Asp Ser His Val Ser Glu Arg Val Lys Asn Lys Val Tyr Gln Leu
 1               5                  10                  15      
Ala Arg Gln Tyr Ser Leu Arg Ile Lys Ser Asn Lys Pro Val Met Ala
            20                  25                  30          
Arg Pro Pro Leu Gln Trp Glu Lys Val Ala Pro Glu Arg Asp Gly Lys
        35                  40                  45              
Ser Pro Thr Val Pro Cys Leu Gln Glu Glu Ala Gly Glu Pro Leu Gly
    50                  55                  60                  
Gly Lys Gly Lys Arg Lys Pro Val Leu Ser Leu Phe Asp Tyr Glu Gln
65                  70                  75                  80  
Leu Met Ala Gln Glu His Ser Pro Pro Lys Pro Ser Ser Ala Gly Glu
                85                  90                  95      
Met Ser Pro Gln Arg Phe Phe Phe Asn Pro Ser Ala Val Ser Gln Arg
            100                 105                 110         
Thr Thr Ser Pro Gly Gly Arg Pro Ser Ala Arg Ser Pro Leu Ser Pro
        115                 120                 125             
Thr Glu Thr Phe Ser Trp Pro Asp Val Arg Glu Leu Cys Ser Lys Tyr
    130                 135                 140                 
Ala Ser Arg Asp Glu Ala Arg Arg Ala Gly Gly Gly Arg Pro Arg Gly
145                 150                 155                 160 
Pro Pro Val Asn Arg Ser His Ser Val Pro Glu Asn Met Val Glu Pro
                165                 170                 175     
Pro Leu Ser Gly Arg Val Gly Arg Cys Arg Ser Leu Ser Thr Lys Arg
            180                 185                 190         
Gly Arg Gly Gly Gly Glu Ala Ala Gln Ser Pro Gly Pro Leu Pro Gln
        195                 200                 205             
Ser Lys Pro Asp Gly Gly Glu Thr Leu Tyr Val Thr Ala Asp Leu Thr
    210                 215                 220                 
Leu Glu Asp Asn Arg Arg Val Ile Val Met Glu Lys Gly Pro Leu Pro
225                 230                 235                 240 
Ser Pro Thr Ala Gly Leu Glu Glu Ser Ser Gly Gln Gly Pro Ser Ser
                245                 250                 255     
Pro Val Ala Leu Leu Gly Gln Val Gln Asp Phe Gln Gln Ser Ala Glu
            260                 265                 270         
Cys Gln Pro Lys Glu Glu Gly Ser Arg Asp Pro Ala Asp Pro Ser Gln
        275                 280                 285             
Gln Gly Arg Val Arg Asn Leu Arg Glu Lys Phe Gln Ala Leu Asn Ser
    290                 295                 300                 
Val Gly
305     


<210> 2092
<211> 1470
<212> PRT
<213> Homo sapiens

<400> 2092
Met Ile Tyr Leu Gly Asp Leu Leu Lys Ala Glu Thr Ala Thr Pro Val
 1               5                  10                  15      
Lys Asn Val Thr Ala Met Asn Ile Pro Ser Leu Val Thr Leu Thr Trp
            20                  25                  30          
Leu Phe Thr Trp Pro Arg Gly Thr Ser Ala Glu Ala Cys Val Met Thr
        35                  40                  45              
Val Ser Thr Thr Pro Trp Gly Ala Thr Val Ser Ser Ala Ser Arg Phe
    50                  55                  60                  
Thr Thr Ser Thr Gln Arg Gly Thr Ser Glu Ile Leu Ile Ser Val Asn
65                  70                  75                  80  
Val Cys Thr Cys Asp Pro Ala Gly Ser Gln Asn Glu Gly Ile Cys Asp
                85                  90                  95      
Ser Tyr Thr Asp Phe Ser Thr Gly Leu Ile Ala Gly Gln Cys Arg Cys
            100                 105                 110         
Lys Leu Asn Val Glu Gly Glu His Cys Asp Val Cys Lys Glu Gly Phe
        115                 120                 125             
Tyr Asp Leu Ser Ser Glu Asp Pro Phe Gly Cys Lys Ser Cys Ala Cys
    130                 135                 140                 
Asn Pro Leu Gly Thr Ile Pro Gly Gly Asn Pro Cys Asp Ser Glu Thr
145                 150                 155                 160 
Gly His Cys Tyr Cys Lys Arg Leu Val Thr Gly Gln His Cys Asp Gln
                165                 170                 175     
Cys Leu Pro Glu His Trp Gly Leu Ser Asn Asp Leu Asp Gly Cys Arg
            180                 185                 190         
Pro Cys Asp Cys Asp Leu Gly Gly Ala Leu Asn Asn Ser Cys Phe Ala
        195                 200                 205             
Glu Ser Gly Gln Cys Ser Cys Arg Pro His Met Ile Gly Arg Gln Cys
    210                 215                 220                 
Asn Glu Val Glu Pro Gly Tyr Tyr Phe Ala Thr Leu Asp His Tyr Leu
225                 230                 235                 240 
Tyr Glu Ala Glu Glu Ala Asn Leu Gly Pro Gly Val Ser Ile Val Glu
                245                 250                 255     
Arg Gln Tyr Ile Gln Asp Arg Ile Pro Ser Trp Thr Gly Ala Gly Phe
            260                 265                 270         
Val Arg Val Pro Glu Gly Ala Tyr Leu Glu Phe Phe Ile Asp Asn Ile
        275                 280                 285             
Pro Tyr Ser Met Glu Tyr Asp Ile Leu Ile Arg Tyr Glu Pro Gln Leu
    290                 295                 300                 
Pro Asp His Trp Glu Lys Ala Val Ile Thr Val Gln Arg Pro Gly Arg
305                 310                 315                 320 
Ile Pro Thr Ser Ser Arg Cys Gly Asn Thr Ile Pro Asp Asp Asp Asn
                325                 330                 335     
Gln Val Val Ser Leu Ser Pro Gly Ser Arg Tyr Val Val Leu Pro Arg
            340                 345                 350         
Pro Val Cys Phe Glu Lys Gly Thr Asn Tyr Thr Val Arg Leu Glu Leu
        355                 360                 365             
Pro Gln Tyr Thr Ser Ser Asp Ser Asp Val Glu Ser Pro Tyr Thr Leu
    370                 375                 380                 
Ile Asp Ser Leu Val Leu Met Pro Tyr Cys Lys Ser Leu Asp Ile Phe
385                 390                 395                 400 
Thr Val Gly Gly Ser Gly Asp Gly Val Val Thr Asn Ser Ala Trp Glu
                405                 410                 415     
Thr Phe Gln Arg Tyr Arg Cys Leu Glu Asn Ser Arg Ser Val Val Lys
            420                 425                 430         
Thr Pro Met Thr Asp Val Cys Arg Asn Ile Ile Phe Ser Ile Ser Ala
        435                 440                 445             
Leu Leu His Gln Thr Gly Leu Ala Cys Glu Cys Asp Pro Gln Gly Ser
    450                 455                 460                 
Leu Ser Ser Val Cys Asp Pro Asn Gly Gly Gln Cys Gln Cys Arg Pro
465                 470                 475                 480 
Asn Val Val Gly Arg Thr Cys Asn Arg Cys Ala Pro Gly Thr Phe Gly
                485                 490                 495     
Phe Gly Pro Ser Gly Cys Lys Pro Cys Glu Cys His Leu Gln Gly Ser
            500                 505                 510         
Val Asn Ala Phe Cys Asn Pro Val Thr Gly Gln Cys His Cys Phe Gln
        515                 520                 525             
Gly Val Tyr Ala Arg Gln Cys Asp Arg Cys Leu Pro Gly His Trp Gly
    530                 535                 540                 
Phe Pro Ser Cys Gln Pro Cys Gln Cys Asn Gly His Ala Asp Asp Cys
545                 550                 555                 560 
Asp Pro Val Thr Gly Glu Cys Leu Asn Cys Gln Asp Tyr Thr Met Gly
                565                 570                 575     
His Asn Cys Glu Arg Cys Leu Ala Gly Tyr Tyr Gly Asp Pro Ile Ile
            580                 585                 590         
Gly Ser Gly Asp His Cys Arg Pro Cys Pro Cys Pro Asp Gly Pro Asp
        595                 600                 605             
Ser Gly Arg Gln Phe Ala Arg Ser Cys Tyr Gln Asp Pro Val Thr Leu
    610                 615                 620                 
Gln Leu Ala Cys Val Cys Asp Pro Gly Tyr Ile Gly Ser Arg Cys Asp
625                 630                 635                 640 
Asp Cys Ala Ser Gly Tyr Phe Gly Asn Pro Ser Glu Val Gly Gly Ser
                645                 650                 655     
Cys Gln Pro Cys Gln Cys His Asn Asn Ile Asp Thr Thr Asp Pro Glu
            660                 665                 670         
Ala Cys Asp Lys Glu Thr Gly Arg Cys Leu Lys Cys Leu Tyr His Thr
        675                 680                 685             
Glu Gly Glu His Cys Gln Phe Cys Arg Phe Gly Tyr Tyr Gly Asp Ala
    690                 695                 700                 
Leu Gln Gln Asp Cys Arg Lys Cys Val Cys Asn Tyr Leu Gly Thr Val
705                 710                 715                 720 
Gln Glu His Cys Asn Gly Ser Asp Cys Gln Cys Asp Lys Ala Thr Gly
                725                 730                 735     
Gln Cys Leu Cys Leu Pro Asn Val Ile Gly Gln Asn Cys Asp Arg Cys
            740                 745                 750         
Ala Pro Asn Thr Trp Gln Leu Ala Ser Gly Thr Gly Cys Asp Pro Cys
        755                 760                 765             
Asn Cys Asn Ala Ala His Ser Phe Gly Pro Ser Cys Asn Glu Phe Thr
    770                 775                 780                 
Gly Gln Cys Gln Cys Met Pro Gly Phe Gly Gly Arg Thr Cys Ser Glu
785                 790                 795                 800 
Cys Gln Glu Leu Phe Trp Gly Asp Pro Asp Val Glu Cys Arg Ala Cys
                805                 810                 815     
Asp Cys Asp Pro Arg Gly Ile Glu Thr Pro Gln Cys Asp Gln Ser Thr
            820                 825                 830         
Gly Gln Cys Val Cys Val Glu Gly Val Glu Gly Pro Arg Cys Asp Lys
        835                 840                 845             
Cys Thr Arg Gly Tyr Ser Gly Val Phe Pro Asp Cys Thr Pro Cys His
    850                 855                 860                 
Gln Cys Phe Ala Leu Trp Asp Val Ile Ile Ala Glu Leu Thr Asn Arg
865                 870                 875                 880 
Thr His Arg Phe Leu Glu Lys Ala Lys Ala Leu Lys Ile Ser Gly Val
                885                 890                 895     
Ile Gly Pro Tyr Arg Glu Thr Val Asp Ser Val Glu Arg Lys Val Ser
            900                 905                 910         
Glu Ile Lys Asp Ile Leu Ala Gln Ser Pro Ala Ala Glu Pro Leu Lys
        915                 920                 925             
Asn Ile Gly Asn Leu Phe Glu Glu Ala Glu Lys Leu Ile Lys Asp Val
    930                 935                 940                 
Thr Glu Met Met Ala Gln Val Glu Val Lys Leu Ser Asp Thr Thr Ser
945                 950                 955                 960 
Gln Ser Asn Ser Thr Ala Lys Glu Leu Asp Ser Leu Gln Thr Glu Ala
                965                 970                 975     
Glu Ser Leu Asp Asn Thr Val Lys Glu Leu Ala Glu Gln Leu Glu Phe
            980                 985                 990         
Ile Lys Asn Ser Asp Ile Arg Gly Ala Leu Asp Ser Ile Thr Lys Tyr
        995                 1000                1005            
Phe Gln Met Ser Leu Glu Ala Glu Glu Arg Val Asn Ala Ser Thr Thr
    1010                1015                1020                
Glu Pro Asn Ser Thr Val Glu Gln Ser Ala Leu Met Arg Asp Arg Val
1025                1030                1035                1040
Glu Asp Val Met Met Glu Arg Glu Ser Gln Phe Lys Glu Lys Gln Glu
                1045                1050                1055    
Glu Gln Ala Arg Leu Leu Asp Glu Leu Ala Gly Lys Leu Gln Ser Leu
            1060                1065                1070        
Asp Leu Ser Ala Ala Ala Glu Met Thr Cys Gly Thr Pro Pro Gly Ala
        1075                1080                1085            
Ser Cys Ser Glu Thr Glu Cys Gly Gly Pro Asn Cys Arg Thr Asp Glu
    1090                1095                1100                
Gly Glu Arg Lys Cys Gly Gly Pro Gly Cys Gly Gly Leu Val Thr Val
1105                1110                1115                1120
Ala His Asn Ala Trp Gln Lys Ala Met Asp Leu Asp Gln Asp Val Leu
                1125                1130                1135    
Ser Ala Leu Ala Glu Val Glu Gln Leu Ser Lys Met Val Ser Glu Ala
            1140                1145                1150        
Lys Leu Arg Ala Asp Glu Ala Lys Gln Ser Ala Glu Asp Ile Leu Leu
        1155                1160                1165            
Lys Thr Asn Ala Thr Lys Glu Lys Met Asp Lys Ser Asn Glu Glu Leu
    1170                1175                1180                
Arg Asn Leu Ile Lys Gln Ile Arg Asn Phe Leu Thr Gln Asp Ser Ala
1185                1190                1195                1200
Asp Leu Asp Ser Ile Glu Ala Val Ala Asn Glu Val Leu Lys Met Glu
                1205                1210                1215    
Met Pro Ser Thr Pro Gln Gln Leu Gln Asn Leu Thr Glu Asp Ile Arg
            1220                1225                1230        
Glu Arg Val Glu Ser Leu Ser Gln Val Glu Val Ile Leu Gln His Ser
        1235                1240                1245            
Ala Ala Asp Ile Ala Arg Ala Glu Met Leu Leu Glu Glu Ala Lys Arg
    1250                1255                1260                
Ala Ser Lys Ser Ala Thr Asp Val Lys Val Thr Ala Asp Met Val Lys
1265                1270                1275                1280
Glu Ala Leu Glu Glu Ala Glu Lys Ala Gln Val Ala Ala Glu Lys Ala
                1285                1290                1295    
Ile Lys Gln Ala Asp Glu Asp Ile Gln Gly Thr Gln Asn Leu Leu Thr
            1300                1305                1310        
Ser Ile Glu Ser Glu Thr Ala Ala Ser Glu Glu Thr Leu Phe Asn Ala
        1315                1320                1325            
Ser Gln Arg Ile Ser Glu Leu Glu Arg Asn Val Glu Glu Leu Lys Arg
    1330                1335                1340                
Lys Ala Ala Gln Asn Ser Gly Glu Ala Glu Tyr Ile Glu Lys Val Val
1345                1350                1355                1360
Tyr Thr Val Lys Gln Ser Ala Glu Asp Val Lys Lys Thr Leu Asp Gly
                1365                1370                1375    
Glu Leu Asp Glu Lys Tyr Lys Lys Val Glu Asn Leu Ile Ala Lys Lys
            1380                1385                1390        
Thr Glu Glu Ser Ala Asp Ala Arg Arg Lys Ala Glu Met Leu Gln Asn
        1395                1400                1405            
Glu Ala Lys Thr Leu Leu Ala Gln Ala Asn Ser Lys Leu Gln Leu Leu
    1410                1415                1420                
Lys Asp Leu Glu Arg Lys Tyr Glu Asp Asn Gln Arg Tyr Leu Glu Asp
1425                1430                1435                1440
Lys Ala Gln Glu Leu Ala Arg Leu Glu Gly Glu Val Arg Ser Leu Leu
                1445                1450                1455    
Lys Asp Ile Ser Gln Lys Val Ala Val Tyr Ser Thr Cys Leu
            1460                1465                1470


<210> 2093
<211> 2106
<212> PRT
<213> Homo sapiens

<400> 2093
Met Thr Ser Ala Thr Glu Phe Glu Asn Val Gly Asn Gln Pro Pro Tyr
 1               5                  10                  15      
Ser Arg Ile Asn Ala Arg Trp Asp Ala Pro Asp Asp Glu Leu Asp Asn
            20                  25                  30          
Asp Asn Ser Ser Ala Arg Leu Phe Glu Arg Ser Arg Ile Lys Ala Leu
        35                  40                  45              
Ala Asp Glu Arg Glu Val Val Gln Lys Lys Thr Phe Thr Lys Trp Val
    50                  55                  60                  
Asn Ser His Leu Ala Arg Val Ser Cys Arg Ile Thr Asp Leu Tyr Lys
65                  70                  75                  80  
Asp Leu Arg Asp Gly Arg Met Leu Ile Lys Leu Leu Glu Val Leu Ser
                85                  90                  95      
Gly Glu Met Leu Pro Lys Pro Thr Lys Gly Lys Met Arg Ile His Cys
            100                 105                 110         
Leu Glu Asn Val Asp Lys Ala Leu Gln Phe Leu Lys Glu Gln Arg Val
        115                 120                 125             
His Leu Glu Asn Met Gly Ser His Asp Ile Val Asp Gly Asn His Arg
    130                 135                 140                 
Leu Val Leu Gly Leu Ile Trp Thr Ile Ile Leu Arg Phe Gln Ile Gln
145                 150                 155                 160 
Asp Ile Val Val Gln Thr Gln Glu Gly Arg Glu Thr Arg Ser Ala Lys
                165                 170                 175     
Asp Ala Leu Leu Leu Trp Cys Gln Met Lys Thr Ala Gly Tyr Pro His
            180                 185                 190         
Val Asn Val Thr Asn Phe Thr Ser Ser Trp Lys Asp Gly Leu Ala Phe
        195                 200                 205             
Asn Ala Leu Ile His Lys His Arg Pro Asp Leu Ile Asp Phe Asp Lys
    210                 215                 220                 
Leu Lys Asp Ser Asn Ala Arg His Asn Leu Glu His Ala Phe Asn Val
225                 230                 235                 240 
Ala Glu Arg Gln Leu Gly Ile Ile Pro Leu Leu Asp Pro Glu Asp Val
                245                 250                 255     
Phe Thr Glu Asn Pro Asp Glu Lys Ser Ile Ile Thr Tyr Val Val Ala
            260                 265                 270         
Phe Tyr His Tyr Phe Ser Lys Met Lys Val Leu Ala Val Glu Gly Lys
        275                 280                 285             
Arg Val Gly Lys Val Ile Asp His Ala Ile Glu Thr Glu Lys Met Ile
    290                 295                 300                 
Glu Lys Tyr Ser Gly Leu Ala Ser Asp Leu Leu Thr Trp Ile Glu Gln
305                 310                 315                 320 
Thr Ile Thr Val Leu Asn Ser Arg Lys Phe Ala Asn Ser Leu Thr Gly
                325                 330                 335     
Val Gln Gln Gln Leu Gln Ala Phe Ser Thr Tyr Arg Thr Val Glu Lys
            340                 345                 350         
Pro Pro Lys Phe Gln Glu Lys Gly Asn Leu Glu Val Leu Leu Phe Thr
        355                 360                 365             
Ile Gln Ser Arg Met Arg Ala Asn Asn Gln Lys Val Tyr Thr Pro His
    370                 375                 380                 
Asp Gly Lys Leu Val Ser Asp Ile Asn Arg Ala Trp Glu Ser Leu Glu
385                 390                 395                 400 
Glu Ala Glu Tyr Arg Arg Glu Leu Ala Leu Arg Asn Glu Leu Ile Arg
                405                 410                 415     
Gln Glu Lys Leu Glu Gln Leu Ala Arg Arg Phe Asp Arg Lys Ala Ala
            420                 425                 430         
Met Arg Glu Thr Trp Leu Ser Glu Asn Gln Arg Leu Val Ala Gln Asp
        435                 440                 445             
Asn Phe Gly Tyr Asp Leu Ala Ala Val Glu Ala Ala Lys Lys Lys His
    450                 455                 460                 
Glu Ala Ile Glu Thr Asp Thr Ala Ala Tyr Glu Glu Arg Val Arg Ala
465                 470                 475                 480 
Leu Glu Asp Leu Ala Gln Glu Leu Glu Lys Glu Asn Tyr His Asp Gln
                485                 490                 495     
Lys Arg Ile Thr Ala Arg Lys Asp Asn Ile Leu Arg Leu Trp Ser Tyr
            500                 505                 510         
Leu Gln Glu Leu Leu Gln Ser Arg Arg Gln Arg Leu Glu Thr Thr Leu
        515                 520                 525             
Ala Leu Gln Lys Leu Phe Gln Asp Met Leu His Ser Ile Asp Trp Met
    530                 535                 540                 
Asp Glu Ile Lys Ala His Leu Leu Ser Ala Glu Phe Gly Lys His Leu
545                 550                 555                 560 
Leu Glu Val Glu Asp Leu Leu Gln Lys His Lys Leu Met Glu Ala Asp
                565                 570                 575     
Ile Ala Ile Gln Gly Asp Lys Val Lys Ala Ile Thr Ala Ala Thr Leu
            580                 585                 590         
Lys Phe Thr Glu Gly Lys Gly Tyr Gln Pro Cys Asp Pro Gln Val Ile
        595                 600                 605             
Gln Asp Arg Ile Ser His Leu Glu Gln Cys Phe Glu Glu Leu Ser Asn
    610                 615                 620                 
Met Ala Ala Gly Arg Lys Ala Gln Leu Glu Gln Ser Lys Arg Leu Trp
625                 630                 635                 640 
Lys Phe Phe Trp Glu Met Asp Glu Ala Glu Ser Trp Ile Lys Glu Lys
                645                 650                 655     
Glu Gln Ile Tyr Ser Ser Leu Asp Tyr Gly Lys Asp Leu Thr Ser Val
            660                 665                 670         
Leu Ile Leu Gln Arg Lys His Lys Ala Phe Glu Asp Glu Leu Arg Gly
        675                 680                 685             
Leu Asp Ala His Leu Glu Gln Ile Phe Gln Glu Ala His Gly Met Val
    690                 695                 700                 
Ala Arg Lys Gln Phe Gly His Pro Gln Ile Glu Ala Arg Ile Lys Glu
705                 710                 715                 720 
Val Ser Ala Gln Trp Asp Gln Leu Lys Asp Leu Ala Ala Phe Cys Lys
                725                 730                 735     
Lys Asn Leu Gln Asp Ala Glu Asn Phe Phe Gln Phe Gln Gly Asp Ala
            740                 745                 750         
Asp Asp Leu Lys Ala Trp Leu Gln Asp Ala His Arg Leu Leu Ser Gly
        755                 760                 765             
Glu Asp Val Gly Gln Asp Glu Gly Ala Thr Arg Ala Leu Gly Lys Lys
    770                 775                 780                 
His Lys Asp Phe Leu Glu Glu Leu Glu Glu Ser Arg Gly Val Met Glu
785                 790                 795                 800 
His Leu Glu Gln Gln Ala Gln Gly Phe Pro Glu Glu Phe Arg Asp Ser
                805                 810                 815     
Pro Asp Val Thr His Arg Leu Gln Ala Leu Arg Glu Leu Tyr Gln Gln
            820                 825                 830         
Val Val Ala Gln Ala Asp Leu Arg Gln Gln Arg Leu Gln Glu Ala Leu
        835                 840                 845             
Asp Leu Tyr Thr Val Phe Gly Glu Thr Asp Ala Cys Glu Leu Trp Met
    850                 855                 860                 
Gly Glu Lys Glu Lys Trp Leu Ala Glu Met Glu Met Pro Asp Thr Leu
865                 870                 875                 880 
Glu Asp Leu Glu Val Val Gln His Arg Phe Asp Ile Leu Asp Gln Glu
                885                 890                 895     
Met Lys Thr Leu Met Thr Gln Ile Asp Gly Val Asn Leu Ala Ala Asn
            900                 905                 910         
Ser Leu Val Glu Ser Gly His Pro Arg Ser Arg Glu Val Lys Gln Tyr
        915                 920                 925             
Gln Asp His Leu Asn Thr Arg Trp Gln Ala Phe Gln Thr Leu Val Ser
    930                 935                 940                 
Glu Arg Arg Glu Ala Val Asp Ser Ala Leu Arg Val His Asn Tyr Cys
945                 950                 955                 960 
Val Asp Cys Glu Glu Thr Ser Lys Trp Ile Thr Asp Lys Thr Lys Val
                965                 970                 975     
Val Glu Ser Thr Lys Asp Leu Gly Arg Asp Leu Ala Gly Ile Ile Ala
            980                 985                 990         
Ile Gln Arg Lys Leu Ser Gly Leu Glu Arg Asp Val Ala Ala Ile Gln
        995                 1000                1005            
Ala Arg Val Asp Ala Leu Glu Arg Glu Ser Gln Gln Leu Met Asp Ser
    1010                1015                1020                
His Pro Glu Gln Lys Glu Asp Ile Gly Gln Arg Gln Lys His Leu Glu
1025                1030                1035                1040
Glu Leu Trp Gln Gly Leu Gln Gln Ser Leu Gln Gly Gln Glu Asp Leu
                1045                1050                1055    
Leu Gly Glu Val Ser Gln Leu Gln Ala Phe Leu Gln Asp Leu Asp Asp
            1060                1065                1070        
Phe Gln Ala Trp Leu Ser Ile Thr Gln Lys Ala Val Ala Ser Glu Asp
        1075                1080                1085            
Met Pro Glu Ser Leu Pro Glu Ala Glu Gln Leu Leu Gln Gln His Ala
    1090                1095                1100                
Gly Ile Lys Asp Glu Ile Asp Gly His Gln Asp Ser Tyr Gln Arg Val
1105                1110                1115                1120
Lys Glu Ser Gly Glu Lys Val Ile Gln Gly Gln Thr Asp Pro Glu Tyr
                1125                1130                1135    
Leu Leu Leu Gly Gln Arg Leu Glu Gly Leu Asp Thr Gly Trp Asn Ala
            1140                1145                1150        
Leu Gly Arg Met Trp Glu Ser Arg Ser His Thr Leu Ala Gln Cys Leu
        1155                1160                1165            
Gly Phe Gln Glu Phe Gln Lys Asp Ala Lys Gln Ala Glu Ala Ile Leu
    1170                1175                1180                
Ser Asn Gln Glu Tyr Thr Leu Ala His Leu Glu Pro Pro Asp Ser Leu
1185                1190                1195                1200
Glu Ala Ala Glu Ala Gly Ile Arg Lys Phe Glu Asp Phe Leu Gly Ser
                1205                1210                1215    
Met Glu Asn Asn Arg Asp Lys Val Leu Ser Pro Val Asp Ser Gly Asn
            1220                1225                1230        
Lys Leu Val Ala Glu Gly Asn Leu Tyr Ser Asp Lys Ile Lys Glu Lys
        1235                1240                1245            
Val Gln Leu Ile Glu Asp Arg His Arg Lys Asn Asn Glu Lys Ala Gln
    1250                1255                1260                
Glu Ala Ser Val Leu Leu Arg Asp Asn Leu Glu Leu Gln Asn Phe Leu
1265                1270                1275                1280
Gln Asn Cys Gln Glu Leu Thr Leu Trp Ile Asn Asp Lys Leu Leu Thr
                1285                1290                1295    
Ser Gln Asp Val Ser Tyr Asp Glu Ala Arg Asn Leu His Asn Lys Trp
            1300                1305                1310        
Leu Lys His Gln Ala Phe Val Ala Glu Leu Ala Ser His Glu Gly Trp
        1315                1320                1325            
Leu Glu Asn Ile Asp Ala Glu Gly Lys Gln Leu Met Asp Glu Lys Pro
    1330                1335                1340                
Gln Phe Thr Ala Leu Val Ser Gln Lys Leu Glu Ala Leu His Arg Leu
1345                1350                1355                1360
Trp Asp Glu Leu Gln Ala Thr Thr Lys Glu Lys Thr Gln His Leu Ser
                1365                1370                1375    
Ala Ala Arg Ser Ser Asp Leu Arg Leu Gln Thr His Ala Asp Leu Asn
            1380                1385                1390        
Lys Trp Ile Ser Ala Met Glu Asp Gln Leu Arg Ser Asp Asp Pro Gly
        1395                1400                1405            
Lys Asp Leu Thr Ser Val Asn Arg Met Leu Ala Lys Leu Lys Arg Val
    1410                1415                1420                
Glu Asp Gln Val Asn Val Arg Lys Glu Glu Leu Gly Glu Leu Phe Ala
1425                1430                1435                1440
Gln Val Pro Ser Met Gly Glu Glu Gly Gly Asp Ala Asp Leu Ser Ile
                1445                1450                1455    
Glu Lys Arg Phe Leu Asp Leu Leu Glu Pro Leu Gly Arg Arg Lys Lys
            1460                1465                1470        
Gln Leu Glu Ser Ser Arg Ala Lys Leu Gln Ile Ser Arg Asp Leu Glu
        1475                1480                1485            
Asp Glu Thr Leu Trp Val Glu Glu Arg Leu Pro Leu Ala Gln Ser Ala
    1490                1495                1500                
Asp Tyr Gly Thr Asn Leu Gln Thr Val Gln Leu Phe Met Lys Lys Asn
1505                1510                1515                1520
Gln Thr Leu Gln Asn Glu Ile Leu Gly His Thr Pro Arg Val Glu Asp
                1525                1530                1535    
Val Leu Gln Arg Gly Gln Gln Leu Val Glu Ala Ala Glu Ile Asp Cys
            1540                1545                1550        
Gln Asp Leu Glu Glu Arg Leu Gly His Leu Gln Ser Ser Trp Asp Arg
        1555                1560                1565            
Leu Arg Glu Ala Ala Ala Gly Arg Leu Gln Arg Leu Arg Asp Ala Asn
    1570                1575                1580                
Glu Ala Gln Gln Tyr Tyr Leu Asp Ala Asp Glu Ala Glu Ala Trp Ile
1585                1590                1595                1600
Gly Glu Gln Glu Leu Tyr Val Ile Ser Asp Glu Ile Pro Lys Asp Glu
                1605                1610                1615    
Glu Gly Ala Ile Val Met Leu Lys Arg His Leu Arg Gln Gln Arg Ala
            1620                1625                1630        
Val Glu Asp Tyr Gly Arg Asn Ile Lys Gln Leu Ala Ser Arg Ala Gln
        1635                1640                1645            
Gly Leu Leu Ser Ala Gly His Pro Glu Gly Glu Gln Ile Ile Arg Leu
    1650                1655                1660                
Gln Gly Gln Val Asp Lys His Tyr Ala Gly Leu Lys Asp Val Ala Glu
1665                1670                1675                1680
Glu Arg Lys Arg Lys Leu Glu Asn Met Tyr His Leu Phe Gln Leu Lys
                1685                1690                1695    
Arg Glu Thr Asp Asp Leu Glu Gln Trp Ile Ser Glu Lys Glu Leu Val
            1700                1705                1710        
Ala Ser Ser Pro Glu Met Gly Gln Asp Phe Asp His Val Thr Leu Leu
        1715                1720                1725            
Arg Asp Lys Phe Arg Asp Phe Ala Arg Glu Thr Gly Ala Ile Gly Gln
    1730                1735                1740                
Glu Arg Val Asp Asn Val Asn Ala Phe Ile Glu Arg Leu Ile Asp Ala
1745                1750                1755                1760
Gly His Ser Glu Ala Ala Thr Ile Ala Glu Trp Lys Asp Gly Leu Asn
                1765                1770                1775    
Glu Met Trp Ala Asp Leu Leu Glu Leu Ile Asp Thr Arg Met Gln Leu
            1780                1785                1790        
Leu Ala Ala Ser Tyr Asp Leu His Arg Tyr Phe Tyr Thr Gly Ala Glu
        1795                1800                1805            
Ile Leu Gly Leu Ile Asp Glu Lys His Arg Glu Leu Pro Glu Asp Val
    1810                1815                1820                
Gly Leu Asp Ala Ser Thr Ala Glu Ser Phe His Arg Val His Thr Ala
1825                1830                1835                1840
Phe Glu Arg Glu Leu His Leu Leu Gly Val Gln Val Gln Gln Phe Gln
                1845                1850                1855    
Asp Val Ala Thr Arg Leu Gln Thr Ala Tyr Ala Gly Glu Lys Ala Glu
            1860                1865                1870        
Ala Ile Gln Asn Lys Glu Gln Glu Val Ser Ala Ala Trp Gln Ala Leu
        1875                1880                1885            
Leu Asp Ala Cys Ala Gly Arg Arg Thr Gln Leu Val Asp Thr Ala Asp
    1890                1895                1900                
Lys Phe Arg Phe Phe Ser Met Ala Arg Asp Leu Leu Ser Trp Met Glu
1905                1910                1915                1920
Ser Ile Ile Arg Gln Ile Glu Thr Gln Glu Arg Pro Arg Asp Val Ser
                1925                1930                1935    
Ser Val Glu Leu Leu Met Lys Tyr His Gln Gly Ile Asn Ala Glu Ile
            1940                1945                1950        
Glu Thr Arg Ser Lys Asn Phe Ser Ala Cys Leu Glu Leu Gly Glu Ser
        1955                1960                1965            
Leu Leu Gln Arg Gln His Gln Ala Ser Glu Glu Ile Arg Glu Lys Leu
    1970                1975                1980                
Gln Gln Val Met Ser Arg Arg Lys Glu Met Asn Glu Lys Trp Glu Ala
1985                1990                1995                2000
Arg Trp Glu Arg Leu Arg Met Leu Leu Glu Val Cys Gln Phe Ser Arg
                2005                2010                2015    
Asp Ala Ser Val Ala Glu Ala Trp Leu Ile Ala Gln Glu Pro Tyr Leu
            2020                2025                2030        
Ala Ser Gly Asp Phe Gly His Thr Val Asp Ser Val Glu Lys Leu Ile
        2035                2040                2045            
Lys Arg His Glu Ala Phe Glu Lys Ser Thr Ala Ser Trp Ala Glu Arg
    2050                2055                2060                
Phe Ala Ala Leu Glu Lys Pro Thr Thr Ala Ser Arg Gly Gly Arg Arg
2065                2070                2075                2080
Asp Ser Arg Gly Gly Ser Ser Phe Pro Pro Cys Gly His Arg Glu Asn
                2085                2090                2095    
Val Pro Gly Gln Ser Leu Val Ser Phe Val
            2100                2105    


<210> 2094
<211> 581
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 67, 68, 69, 70, 71, 72
<223> Xaa = Any Amino Acid

<400> 2094
Met Ser Ser Ser Lys Lys Ser Lys Glu Lys Glu Lys Glu Lys Asp Lys
 1               5                  10                  15      
Ile Lys Glu Lys Glu Lys Asp Ser Lys Asp Lys Glu Lys Asp Lys Lys
            20                  25                  30          
Thr Val Asn Gly His Thr Phe Ser Ser Ile Pro Val Val Gly Pro Ile
        35                  40                  45              
Ser Cys Ser Gln Cys Met Lys Pro Phe Thr Asn Lys Asp Ala Tyr Thr
    50                  55                  60                  
Cys Ala Xaa Xaa Xaa Xaa Xaa Xaa Ala Phe Val His Lys Gly Cys Arg
65                  70                  75                  80  
Glu Ser Leu Ala Ser Cys Ala Lys Val Lys Met Lys Gln Pro Lys Gly
                85                  90                  95      
Ser Leu Gln Ala His Asp Thr Ser Ser Leu Pro Thr Val Ile Met Arg
            100                 105                 110         
Asn Lys Pro Ser Gln Pro Lys Glu Arg Pro Arg Ser Ala Val Leu Leu
        115                 120                 125             
Val Asp Glu Thr Ala Thr Thr Pro Ile Phe Ala Asn Arg Arg Ser Gln
    130                 135                 140                 
Gln Ser Val Ser Leu Ser Lys Ser Val Ser Ile Gln Asn Ile Thr Gly
145                 150                 155                 160 
Val Gly Asn Asp Glu Asn Met Ser Asn Thr Trp Lys Phe Leu Ser His
                165                 170                 175     
Ser Thr Asp Ser Leu Asn Lys Ile Ser Lys Val Asn Glu Ser Thr Glu
            180                 185                 190         
Ser Leu Thr Asp Glu Gly Thr Asp Met Asn Glu Gly Gln Leu Leu Gly
        195                 200                 205             
Asp Phe Glu Ile Glu Ser Lys Gln Leu Glu Ala Glu Ser Trp Ser Arg
    210                 215                 220                 
Ile Ile Asp Ser Lys Phe Leu Lys Gln Gln Lys Lys Asp Val Val Lys
225                 230                 235                 240 
Arg Gln Glu Val Ile Tyr Glu Leu Met Gln Thr Glu Phe His His Val
                245                 250                 255     
Arg Thr Leu Lys Ile Met Ser Gly Val Tyr Ser Gln Gly Met Met Ala
            260                 265                 270         
Asp Leu Leu Phe Glu Gln Gln Met Val Glu Lys Leu Phe Pro Cys Leu
        275                 280                 285             
Asp Glu Leu Ile Ser Ile His Ser Gln Phe Phe Gln Arg Ile Leu Glu
    290                 295                 300                 
Arg Lys Lys Glu Ser Leu Val Asp Lys Ser Glu Lys Asn Phe Leu Ile
305                 310                 315                 320 
Lys Arg Ile Gly Asp Val Leu Val Asn Gln Phe Ser Gly Glu Asn Ala
                325                 330                 335     
Glu Arg Leu Lys Lys Thr Tyr Gly Lys Phe Cys Gly Gln His Asn Gln
            340                 345                 350         
Ser Val Asn Tyr Phe Lys Asp Leu Tyr Ala Lys Asp Lys Arg Phe Gln
        355                 360                 365             
Ala Phe Val Lys Lys Lys Met Ser Ser Ser Val Val Arg Arg Leu Gly
    370                 375                 380                 
Ile Pro Glu Cys Ile Leu Leu Val Thr Gln Arg Ile Thr Lys Tyr Pro
385                 390                 395                 400 
Val Leu Phe Gln Arg Ile Leu Gln Cys Thr Lys Asp Asn Glu Val Glu
                405                 410                 415     
Gln Glu Asp Leu Ala Gln Ser Leu Ser Leu Val Lys Asp Val Ile Gly
            420                 425                 430         
Ala Val Asp Ser Lys Val Ala Ser Tyr Glu Lys Lys Val Arg Leu Asn
        435                 440                 445             
Glu Ile Tyr Thr Lys Thr Asp Ser Lys Ser Ile Met Arg Met Lys Ser
    450                 455                 460                 
Gly Gln Met Phe Ala Lys Glu Asp Leu Lys Arg Lys Lys Leu Val Arg
465                 470                 475                 480 
Asp Gly Ser Val Phe Leu Lys Asn Ala Ala Gly Arg Leu Lys Glu Val
                485                 490                 495     
Gln Ala Val Leu Leu Thr Asp Ile Leu Val Phe Leu Gln Glu Lys Asp
            500                 505                 510         
Gln Lys Tyr Ile Phe Ala Ser Leu Asp Gln Lys Ser Thr Val Ile Ser
        515                 520                 525             
Leu Lys Lys Leu Ile Val Arg Glu Val Ala His Glu Glu Lys Gly Leu
    530                 535                 540                 
Phe Leu Ile Ser Met Gly Met Thr Asp Pro Glu Met Val Glu Val His
545                 550                 555                 560 
Ala Ser Ser Lys Glu Glu Arg Asn Ser Trp Ile Gln Ile Ile Gln Asp
                565                 570                 575     
Thr Ile Asn Thr Leu
            580     


<210> 2095
<211> 448
<212> PRT
<213> Homo sapiens

<400> 2095
Met Leu Trp Leu Ala Leu Gly Pro Phe Pro Ala Met Glu Asn Gln Val
 1               5                  10                  15      
Leu Val Ile Arg Ile Lys Ile Pro Asn Ser Gly Ala Val Asp Trp Thr
            20                  25                  30          
Val His Ser Gly Pro Gln Leu Leu Phe Arg Asp Val Leu Asp Val Ile
        35                  40                  45              
Gly Gln Val Leu Pro Glu Ala Thr Thr Thr Ala Phe Glu Tyr Glu Asp
    50                  55                  60                  
Glu Asp Gly Asp Arg Ile Thr Val Arg Ser Asp Glu Glu Met Lys Ala
65                  70                  75                  80  
Met Leu Ser Tyr Tyr Tyr Ser Thr Val Met Glu Gln Gln Val Asn Gly
                85                  90                  95      
Gln Leu Ile Glu Pro Leu Gln Ile Phe Pro Arg Ala Cys Lys Pro Pro
            100                 105                 110         
Gly Glu Arg Asn Ile His Gly Leu Lys Val Asn Thr Arg Ala Gly Pro
        115                 120                 125             
Ser Gln His Ser Ser Pro Ala Val Ser Asp Ser Leu Pro Ser Asn Ser
    130                 135                 140                 
Leu Lys Lys Ser Ser Ala Glu Leu Lys Lys Ile Leu Ala Asn Gly Gln
145                 150                 155                 160 
Met Asn Glu Gln Asp Ile Arg Tyr Arg Asp Thr Leu Gly His Gly Asn
                165                 170                 175     
Gly Gly Thr Val Tyr Lys Ala Tyr His Val Pro Ser Gly Lys Ile Leu
            180                 185                 190         
Ala Val Lys Val Ile Leu Leu Asp Ile Thr Leu Glu Leu Gln Lys Gln
        195                 200                 205             
Ile Met Ser Glu Leu Glu Ile Leu Tyr Lys Cys Asp Ser Ser Tyr Ile
    210                 215                 220                 
Ile Gly Phe Tyr Gly Ala Phe Phe Val Glu Asn Arg Ile Ser Ile Cys
225                 230                 235                 240 
Thr Glu Phe Met Asp Gly Gly Ser Leu Asp Val Tyr Arg Lys Met Pro
                245                 250                 255     
Glu His Val Leu Gly Arg Ile Ala Val Ala Val Val Lys Gly Leu Thr
            260                 265                 270         
Tyr Leu Trp Ser Leu Lys Ile Leu His Arg Asp Val Lys Pro Ser Asn
        275                 280                 285             
Met Leu Val Asn Thr Arg Gly Gln Val Lys Leu Cys Asp Phe Gly Val
    290                 295                 300                 
Ser Thr Gln Leu Val Asn Ser Ile Ala Lys Thr Tyr Val Gly Thr Asn
305                 310                 315                 320 
Ala Tyr Met Ala Pro Glu Arg Ile Ser Gly Glu Gln Tyr Gly Ile His
                325                 330                 335     
Ser Asp Val Trp Ser Leu Gly Ile Ser Phe Met Glu Leu Ala Leu Gly
            340                 345                 350         
Arg Phe Pro Tyr Pro Gln Ile Gln Lys Asn Gln Gly Ser Leu Met Pro
        355                 360                 365             
Leu Gln Leu Leu Gln Cys Ile Val Asp Glu Asp Ser Pro Val Leu Pro
    370                 375                 380                 
Val Gly Glu Phe Ser Glu Pro Phe Val His Phe Ile Thr Gln Cys Met
385                 390                 395                 400 
Arg Lys Gln Pro Lys Glu Arg Pro Ala Pro Glu Glu Leu Met Gly His
                405                 410                 415     
Pro Phe Ile Val Gln Phe Asn Asp Gly Asn Ala Ala Val Val Ser Met
            420                 425                 430         
Trp Val Cys Arg Ala Leu Glu Glu Arg Arg Ser Gln Gln Gly Pro Pro
        435                 440                 445             


<210> 2096
<211> 715
<212> PRT
<213> Homo sapiens

<400> 2096
Met Asn Phe Leu Leu Lys Ala Glu Val Gln Lys Leu Gln Ala Leu Ala
 1               5                  10                  15      
Asn Glu Gln Ala Ala Ala Ala His Glu Leu Glu Lys Met Gln Gln Ser
            20                  25                  30          
Val Tyr Val Lys Asp Asp Lys Ile Arg Leu Leu Glu Glu Gln Leu Gln
        35                  40                  45              
His Glu Ile Ser Asn Lys Met Glu Glu Phe Lys Ile Leu Asn Asp Gln
    50                  55                  60                  
Asn Lys Ala Leu Lys Ser Glu Val Gln Lys Leu Gln Thr Leu Val Ser
65                  70                  75                  80  
Glu Gln Pro Asn Lys Asp Val Val Glu Gln Met Glu Lys Cys Ile Gln
                85                  90                  95      
Glu Lys Asp Glu Lys Leu Lys Thr Val Glu Glu Leu Leu Glu Thr Gly
            100                 105                 110         
Leu Ile Gln Val Ala Thr Lys Glu Glu Glu Leu Asn Ala Ile Arg Thr
        115                 120                 125             
Glu Asn Ser Ser Leu Thr Lys Glu Val Gln Asp Leu Lys Ala Lys Gln
    130                 135                 140                 
Asn Asp Gln Val Ser Phe Ala Ser Leu Val Glu Glu Leu Lys Lys Val
145                 150                 155                 160 
Ile His Glu Lys Asp Gly Lys Ile Lys Ser Val Glu Glu Leu Leu Glu
                165                 170                 175     
Ala Glu Leu Leu Lys Val Ala Asn Lys Glu Lys Thr Val Gln Asp Leu
            180                 185                 190         
Lys Gln Glu Ile Lys Ala Leu Lys Glu Glu Ile Gly Asn Val Gln Leu
        195                 200                 205             
Glu Lys Ala Gln Gln Leu Ser Ile Thr Ser Lys Val Gln Glu Leu Gln
    210                 215                 220                 
Asn Leu Leu Lys Gly Lys Glu Glu Gln Met Asn Thr Met Lys Ala Val
225                 230                 235                 240 
Leu Glu Glu Lys Glu Lys Asp Leu Ala Asn Thr Gly Lys Trp Leu Gln
                245                 250                 255     
Asp Leu Gln Glu Glu Asn Glu Ser Leu Lys Ala His Val Gln Glu Val
            260                 265                 270         
Ala Gln His Asn Leu Lys Glu Ala Ser Ser Ala Ser Gln Phe Glu Glu
        275                 280                 285             
Leu Glu Ile Val Leu Lys Glu Lys Glu Asn Glu Leu Lys Arg Leu Glu
    290                 295                 300                 
Ala Met Leu Lys Glu Arg Glu Ser Asp Leu Ser Ser Lys Thr Gln Leu
305                 310                 315                 320 
Leu Gln Asp Val Gln Asp Glu Asn Lys Leu Phe Lys Ser Gln Ile Glu
                325                 330                 335     
Gln Leu Lys Gln Gln Asn Tyr Gln Gln Ala Ser Ser Phe Pro Pro His
            340                 345                 350         
Glu Glu Leu Leu Lys Val Ile Ser Glu Arg Glu Lys Glu Ile Ser Gly
        355                 360                 365             
Leu Trp Asn Glu Leu Asp Ser Leu Lys Asp Ala Val Glu His Gln Arg
    370                 375                 380                 
Lys Lys Asn Asn Asp Leu Arg Glu Lys Asn Trp Glu Ala Met Glu Ala
385                 390                 395                 400 
Leu Ala Ser Thr Glu Lys Met Leu Gln Asp Lys Val Asn Lys Thr Ser
                405                 410                 415     
Lys Glu Arg Gln Gln Gln Val Glu Ala Val Glu Leu Glu Ala Lys Glu
            420                 425                 430         
Val Leu Lys Lys Leu Phe Pro Lys Val Ser Val Pro Ser Asn Leu Ser
        435                 440                 445             
Tyr Gly Glu Trp Leu His Gly Phe Glu Lys Lys Ala Lys Glu Cys Met
    450                 455                 460                 
Ala Gly Thr Ser Gly Ser Glu Glu Val Lys Val Leu Glu His Lys Leu
465                 470                 475                 480 
Lys Glu Ala Asp Glu Met His Thr Leu Leu Gln Leu Glu Cys Glu Lys
                485                 490                 495     
Tyr Lys Ser Val Leu Ala Glu Thr Glu Gly Ile Leu Gln Lys Leu Gln
            500                 505                 510         
Arg Ser Val Glu Gln Glu Glu Asn Lys Trp Lys Val Lys Val Asp Glu
        515                 520                 525             
Ser His Lys Thr Ile Lys Gln Met Gln Ser Ser Phe Thr Ser Ser Glu
    530                 535                 540                 
Gln Glu Leu Glu Arg Leu Arg Ser Glu Asn Lys Asp Ile Glu Asn Leu
545                 550                 555                 560 
Arg Arg Glu Arg Glu His Leu Glu Met Glu Leu Glu Lys Ala Glu Met
                565                 570                 575     
Glu Arg Ser Thr Tyr Val Thr Glu Val Arg Glu Leu Lys Asp Leu Leu
            580                 585                 590         
Thr Glu Leu Gln Lys Lys Leu Asp Asp Ser Tyr Ser Glu Ala Val Arg
        595                 600                 605             
Gln Asn Glu Glu Leu Asn Leu Leu Lys Ala Gln Leu Asn Glu Thr Leu
    610                 615                 620                 
Thr Lys Leu Arg Thr Glu Gln Asn Glu Arg Gln Lys Val Ala Gly Asp
625                 630                 635                 640 
Leu His Lys Ala Gln Gln Ser Leu Glu Leu Ile Gln Ser Lys Ile Val
                645                 650                 655     
Lys Ala Ala Gly Asp Thr Thr Val Ile Glu Asn Ser Asp Val Ser Pro
            660                 665                 670         
Glu Thr Glu Ser Ser Glu Lys Glu Thr Met Ser Val Ser Leu Asn Gln
        675                 680                 685             
Thr Val Thr Gln Leu Gln Gln Leu Leu Gln Ala Val Asn Gln Gln Leu
    690                 695                 700                 
Thr Lys Glu Lys Glu His Tyr Gln Val Leu Glu
705                 710                 715 


<210> 2097
<211> 1782
<212> PRT
<213> Homo sapiens

<400> 2097
Met Gly Ala Gly Ser Ser Thr Glu Gln Arg Ser Pro Glu Gln Pro Pro
 1               5                  10                  15      
Glu Gly Ser Ser Thr Pro Ala Glu Pro Glu Pro Ser Gly Gly Gly Pro
            20                  25                  30          
Ser Ala Glu Ala Ala Pro Asp Thr Thr Ala Asp Pro Ala Ile Ala Ala
        35                  40                  45              
Ser Asp Pro Ala Thr Lys Leu Leu Gln Lys Asn Gly Gln Leu Ser Thr
    50                  55                  60                  
Ile Asn Gly Val Ala Glu Gln Asp Glu Leu Ser Leu Gln Glu Gly Asp
65                  70                  75                  80  
Leu Asn Gly Gln Lys Gly Ala Leu Asn Gly Gln Gly Ala Leu Asn Ser
                85                  90                  95      
Gln Glu Glu Glu Glu Val Ile Val Thr Glu Val Gly Gln Arg Asp Ser
            100                 105                 110         
Glu Asp Val Ser Lys Arg Asp Ser Asp Lys Glu Met Ala Thr Lys Ser
        115                 120                 125             
Ala Val Val His Asp Ile Thr Asp Asp Gly Gln Glu Glu Thr Pro Glu
    130                 135                 140                 
Ile Ile Glu Gln Ile Pro Ser Ser Glu Ser Asn Leu Glu Glu Leu Thr
145                 150                 155                 160 
Gln Pro Thr Glu Ser Gln Ala Asn Asp Ile Gly Phe Lys Lys Val Phe
                165                 170                 175     
Lys Phe Val Gly Phe Lys Phe Thr Val Lys Lys Asp Lys Thr Glu Lys
            180                 185                 190         
Pro Asp Thr Val Gln Leu Leu Thr Val Lys Lys Asp Glu Gly Glu Gly
        195                 200                 205             
Ala Ala Gly Ala Gly Asp His Lys Asp Pro Ser Leu Gly Ala Gly Glu
    210                 215                 220                 
Ala Ala Ser Lys Glu Ser Glu Pro Lys Gln Ser Thr Glu Lys Pro Glu
225                 230                 235                 240 
Glu Thr Leu Lys Arg Glu Gln Ser His Ala Glu Ile Ser Pro Pro Ala
                245                 250                 255     
Glu Ser Gly Gln Ala Val Glu Glu Cys Lys Glu Glu Gly Glu Glu Lys
            260                 265                 270         
Gln Glu Lys Glu Pro Ser Lys Ser Ala Glu Ser Pro Thr Ser Pro Val
        275                 280                 285             
Thr Ser Glu Thr Gly Ser Thr Phe Lys Lys Phe Phe Thr Gln Gly Trp
    290                 295                 300                 
Ala Gly Trp Arg Lys Lys Thr Ser Phe Arg Lys Pro Lys Glu Asp Glu
305                 310                 315                 320 
Val Glu Ala Ser Glu Lys Lys Lys Glu Gln Glu Pro Glu Lys Val Asp
                325                 330                 335     
Thr Glu Glu Asp Gly Lys Ala Glu Val Ala Ser Glu Lys Leu Thr Ala
            340                 345                 350         
Ser Glu Gln Ala His Pro Gln Glu Pro Ala Glu Ser Ala His Glu Pro
        355                 360                 365             
Arg Leu Ser Ala Glu Tyr Glu Lys Val Glu Leu Pro Ser Glu Glu Gln
    370                 375                 380                 
Val Ser Gly Ser Gln Gly Pro Ser Glu Glu Lys Pro Ala Pro Leu Ala
385                 390                 395                 400 
Thr Glu Val Phe Asp Glu Lys Ile Glu Val His Gln Glu Glu Val Val
                405                 410                 415     
Ala Glu Val His Val Ser Thr Val Glu Glu Arg Thr Glu Glu Gln Lys
            420                 425                 430         
Thr Glu Val Glu Glu Thr Ala Gly Ser Val Pro Ala Glu Glu Leu Val
        435                 440                 445             
Glu Met Asp Ala Glu Pro Gln Glu Ala Glu Pro Ala Lys Glu Leu Val
    450                 455                 460                 
Lys Leu Lys Glu Thr Cys Val Ser Gly Glu Asp Pro Thr Gln Gly Ala
465                 470                 475                 480 
Asp Leu Ser Pro Asp Glu Lys Val Leu Ser Lys Pro Pro Glu Gly Val
                485                 490                 495     
Val Ser Glu Val Glu Met Leu Ser Ser Gln Glu Arg Met Lys Val Gln
            500                 505                 510         
Gly Ser Pro Leu Lys Lys Leu Phe Thr Ser Thr Gly Leu Lys Lys Leu
        515                 520                 525             
Ser Gly Lys Lys Gln Lys Gly Lys Arg Gly Gly Gly Asp Glu Glu Ser
    530                 535                 540                 
Gly Glu His Thr Gln Val Pro Ala Asp Ser Pro Asp Ser Gln Glu Glu
545                 550                 555                 560 
Gln Lys Gly Glu Ser Ser Ala Ser Ser Pro Glu Glu Pro Glu Glu Ile
                565                 570                 575     
Thr Cys Leu Glu Lys Gly Leu Ala Glu Val Gln Gln Asp Gly Glu Ala
            580                 585                 590         
Glu Glu Gly Ala Thr Ser Asp Gly Glu Lys Lys Arg Glu Gly Val Thr
        595                 600                 605             
Pro Trp Ala Ser Phe Lys Lys Met Val Thr Pro Lys Lys Arg Val Arg
    610                 615                 620                 
Arg Pro Ser Glu Ser Asp Lys Glu Asp Glu Leu Asp Lys Val Lys Ser
625                 630                 635                 640 
Ala Thr Leu Ser Ser Thr Glu Ser Thr Ala Ser Glu Met Gln Glu Glu
                645                 650                 655     
Met Lys Gly Ser Val Glu Glu Pro Lys Pro Glu Glu Pro Lys Arg Lys
            660                 665                 670         
Val Asp Thr Ser Val Ser Trp Glu Ala Leu Ile Cys Val Gly Ser Ser
        675                 680                 685             
Lys Lys Arg Ala Arg Arg Gly Ser Ser Ser Asp Glu Glu Gly Gly Pro
    690                 695                 700                 
Lys Ala Met Gly Gly Asp His Gln Lys Ala Asp Glu Ala Gly Lys Asp
705                 710                 715                 720 
Lys Glu Thr Gly Thr Asp Gly Ile Leu Ala Gly Ser Gln Glu His Asp
                725                 730                 735     
Pro Gly Gln Gly Ser Ser Ser Pro Glu Gln Ala Gly Ser Pro Thr Glu
            740                 745                 750         
Gly Glu Gly Val Ser Thr Trp Glu Ser Phe Lys Arg Leu Val Thr Pro
        755                 760                 765             
Arg Lys Lys Ser Lys Ser Lys Leu Glu Glu Lys Ser Glu Asp Ser Ile
    770                 775                 780                 
Ala Gly Ser Gly Val Glu His Ser Thr Pro Asp Thr Glu Pro Gly Lys
785                 790                 795                 800 
Glu Glu Ser Trp Val Ser Ile Lys Lys Phe Ile Pro Gly Arg Arg Lys
                805                 810                 815     
Lys Arg Pro Asp Gly Lys Gln Glu Gln Ala Pro Val Glu Asp Ala Gly
            820                 825                 830         
Pro Thr Gly Ala Asn Glu Asp Asp Ser Asp Val Pro Ala Val Val Pro
        835                 840                 845             
Leu Ser Glu Tyr Asp Ala Val Glu Arg Glu Lys Met Glu Ala Gln Gln
    850                 855                 860                 
Ala Gln Lys Ser Ala Glu Gln Pro Glu Gln Lys Ala Ala Thr Glu Val
865                 870                 875                 880 
Ser Lys Glu Leu Ser Glu Ser Gln Val His Met Met Ala Ala Ala Val
                885                 890                 895     
Ala Asp Gly Thr Arg Ala Ala Thr Ile Ile Glu Glu Arg Ser Pro Ser
            900                 905                 910         
Trp Ile Ser Ala Ser Val Thr Glu Pro Leu Glu Gln Val Glu Ala Glu
        915                 920                 925             
Ala Ala Leu Leu Thr Glu Glu Val Leu Glu Arg Glu Val Ile Ala Glu
    930                 935                 940                 
Glu Glu Pro Pro Thr Val Thr Glu Pro Leu Pro Glu Asn Arg Glu Ala
945                 950                 955                 960 
Arg Gly Asp Thr Val Val Ser Glu Ala Glu Leu Thr Pro Glu Ala Val
                965                 970                 975     
Thr Ala Ala Glu Thr Ala Gly Pro Leu Gly Ala Glu Glu Gly Thr Glu
            980                 985                 990         
Ala Ser Ala Ala Glu Glu Thr Thr Glu Met Val Ser Ala Val Ser Gln
        995                 1000                1005            
Leu Thr Asp Ser Pro Asp Thr Thr Glu Glu Ala Thr Pro Val Gln Glu
    1010                1015                1020                
Val Glu Gly Gly Val Pro Asp Ile Glu Glu Gln Glu Arg Arg Thr Gln
1025                1030                1035                1040
Glu Val Leu Gln Ala Val Ala Glu Lys Val Lys Glu Glu Ser Gln Leu
                1045                1050                1055    
Pro Gly Thr Gly Gly Pro Glu Asp Val Leu Gln Pro Val Gln Arg Ala
            1060                1065                1070        
Glu Ala Glu Arg Pro Glu Glu Gln Ala Glu Ala Ser Gly Leu Lys Lys
        1075                1080                1085            
Glu Thr Asp Val Val Leu Lys Val Asp Ala Gln Glu Ala Lys Thr Glu
    1090                1095                1100                
Pro Phe Thr Gln Gly Lys Val Val Gly Gln Thr Thr Pro Glu Ser Phe
1105                1110                1115                1120
Glu Lys Ala Pro Gln Val Thr Glu Ser Ile Glu Ser Ser Glu Leu Val
                1125                1130                1135    
Thr Thr Cys Gln Ala Glu Thr Leu Ala Gly Val Lys Ser Gln Glu Met
            1140                1145                1150        
Val Met Glu Gln Ala Ile Pro Pro Asp Ser Val Glu Thr Pro Thr Asp
        1155                1160                1165            
Ser Glu Thr Asp Gly Ser Thr Pro Val Ala Asp Phe Asp Ala Pro Gly
    1170                1175                1180                
Thr Thr Gln Lys Asp Glu Ile Val Glu Ile His Glu Glu Asn Glu Val
1185                1190                1195                1200
Ala Ser Gly Thr Gln Ser Gly Gly Thr Glu Ala Glu Ala Val Pro Ala
                1205                1210                1215    
Gln Lys Glu Arg Pro Pro Ala Pro Ser Ser Phe Val Phe Gln Glu Glu
            1220                1225                1230        
Thr Lys Glu Gln Ser Lys Met Glu Asp Thr Leu Glu His Thr Asp Lys
        1235                1240                1245            
Glu Val Ser Val Glu Thr Val Ser Ile Leu Ser Lys Thr Glu Gly Thr
    1250                1255                1260                
Gln Glu Ala Asp Gln Tyr Ala Asp Glu Lys Thr Lys Asp Val Pro Phe
1265                1270                1275                1280
Phe Glu Gly Leu Glu Gly Ser Ile Asp Thr Gly Ile Thr Val Ser Arg
                1285                1290                1295    
Glu Lys Val Thr Glu Val Ala Leu Lys Gly Glu Gly Thr Glu Glu Ala
            1300                1305                1310        
Glu Cys Lys Lys Asp Asp Ala Leu Glu Leu Gln Ser His Ala Lys Ser
        1315                1320                1325            
Pro Pro Ser Pro Val Glu Arg Glu Met Val Val Gln Val Glu Arg Glu
    1330                1335                1340                
Lys Thr Glu Ala Glu Pro Thr His Val Asn Glu Glu Lys Leu Glu His
1345                1350                1355                1360
Glu Thr Ala Val Thr Val Ser Glu Glu Val Ser Lys Gln Leu Leu Gln
                1365                1370                1375    
Thr Val Asn Val Pro Ile Ile Asp Gly Ala Lys Glu Val Ser Ser Leu
            1380                1385                1390        
Glu Gly Ser Pro Pro Pro Cys Leu Gly Gln Glu Glu Ala Val Cys Thr
        1395                1400                1405            
Lys Ile Gln Val Gln Ser Ser Glu Ala Ser Phe Thr Leu Thr Ala Ala
    1410                1415                1420                
Ala Glu Glu Glu Lys Val Leu Gly Glu Thr Ala Asn Ile Leu Glu Thr
1425                1430                1435                1440
Gly Glu Thr Leu Glu Pro Ala Gly Ala His Leu Val Leu Glu Glu Lys
                1445                1450                1455    
Ser Ser Glu Lys Asn Glu Asp Phe Ala Ala His Pro Gly Glu Asp Ala
            1460                1465                1470        
Val Pro Thr Gly Pro Asp Cys Gln Ala Lys Ser Thr Pro Val Ile Val
        1475                1480                1485            
Ser Ala Thr Thr Lys Lys Gly Leu Ser Ser Asp Leu Glu Gly Glu Lys
    1490                1495                1500                
Thr Thr Ser Leu Lys Trp Lys Ser Asp Glu Val Asp Glu Gln Val Ala
1505                1510                1515                1520
Cys Gln Glu Val Lys Val Ser Val Ala Ile Glu Asp Leu Glu Pro Glu
                1525                1530                1535    
Asn Gly Ile Leu Glu Leu Glu Thr Lys Ser Ser Lys Leu Val Gln Asn
            1540                1545                1550        
Ile Ile Gln Thr Ala Val Asp Gln Phe Val Arg Thr Glu Glu Thr Ala
        1555                1560                1565            
Thr Glu Met Leu Thr Ser Glu Leu Gln Thr Gln Ala His Val Ile Lys
    1570                1575                1580                
Ala Asp Ser Gln Asp Ala Gly Gln Glu Thr Glu Lys Glu Gly Glu Glu
1585                1590                1595                1600
Pro Gln Ala Ser Ala Gln Asp Glu Thr Pro Ile Thr Ser Ala Lys Glu
                1605                1610                1615    
Glu Ser Glu Ser Thr Ala Val Gly Gln Ala His Ser Asp Ile Ser Lys
            1620                1625                1630        
Asp Met Ser Glu Ala Ser Glu Lys Thr Met Thr Val Glu Val Glu Gly
        1635                1640                1645            
Ser Thr Val Asn Asp Gln Gln Leu Glu Glu Val Val Leu Pro Ser Glu
    1650                1655                1660                
Glu Glu Gly Gly Gly Ala Gly Thr Lys Ser Val Pro Glu Asp Asp Gly
1665                1670                1675                1680
His Ala Leu Leu Ala Glu Arg Ile Glu Lys Ser Leu Val Glu Pro Lys
                1685                1690                1695    
Glu Asp Glu Lys Gly Asp Asp Val Asp Asp Pro Glu Asn Gln Asn Ser
            1700                1705                1710        
Ala Leu Ala Asp Thr Asp Ala Ser Gly Gly Leu Thr Lys Glu Ser Pro
        1715                1720                1725            
Asp Thr Asn Gly Pro Lys Gln Lys Glu Lys Glu Asp Ala Gln Glu Val
    1730                1735                1740                
Glu Leu Gln Glu Gly Lys Val His Ser Glu Ser Asp Lys Ala Ile Thr
1745                1750                1755                1760
Pro Gln Ala Gln Glu Glu Leu Gln Lys Gln Glu Arg Glu Ser Ala Lys
                1765                1770                1775    
Ser Glu Leu Thr Glu Ser
            1780        


<210> 2098
<211> 159
<212> PRT
<213> Homo sapiens

<400> 2098
Met Ile Lys Phe Phe Leu Met Val Asn Lys Gln Gly Gln Thr Arg Leu
 1               5                  10                  15      
Ser Lys Tyr Tyr Glu His Val Asp Ile Asn Lys Arg Thr Leu Leu Glu
            20                  25                  30          
Thr Glu Val Ile Lys Ser Cys Leu Ser Arg Ser Asn Glu Gln Cys Ser
        35                  40                  45              
Phe Ile Glu Tyr Lys Asp Phe Lys Leu Ile Tyr Arg Gln Tyr Ala Ala
    50                  55                  60                  
Leu Phe Ile Val Val Gly Val Asn Asp Thr Glu Asn Glu Met Ala Ile
65                  70                  75                  80  
Tyr Glu Phe Ile His Asn Phe Val Glu Val Leu Asp Glu Tyr Phe Ser
                85                  90                  95      
Arg Val Ser Glu Leu Asp Val Ser Phe Phe Asn Thr Val Phe His Ser
            100                 105                 110         
Thr Trp Gln Met His Ser Gly Pro Tyr Gln Glu Pro Ile Asp Glu Leu
        115                 120                 125             
Pro Lys Ile Cys Ser Ala Leu Glu Pro Gln Gln Thr Cys Phe Ser Pro
    130                 135                 140                 
Asp Ser Ser Ser Phe Lys Gly Ala Ala Ser Thr Thr Pro Ile Tyr
145                 150                 155                 


<210> 2099
<211> 489
<212> PRT
<213> Homo sapiens

<400> 2099
Met Tyr Ser Ala Met Ser Pro Phe Ser Lys Ala Thr Leu Asp Thr Ser
 1               5                  10                  15      
Lys Leu Tyr Val Ser Ser Ser Phe Thr Asn Lys Ile Pro Asp Glu Gly
            20                  25                  30          
Asp Thr Thr Pro Glu Lys Pro Glu Asp Pro Ser Ala Leu Ser Lys Gln
        35                  40                  45              
Ser Ser Glu Val Ser Met Arg Glu Glu Ser Asp Ile Asp Gln Asn Gln
    50                  55                  60                  
Ser Asp Asp Gly Asp Thr Glu Thr Ser Pro Thr Lys Ser Pro Thr Thr
65                  70                  75                  80  
Pro Lys Ser Val Lys Asn Lys Asn Ser Ser Glu Phe Pro Leu Phe Ser
                85                  90                  95      
Tyr Asn Asn Gly Val Val Met Thr Ser Cys Arg Glu Leu Asp Asn Asn
            100                 105                 110         
Arg Ser Ala Leu Ser Ala Ala Ser Ala Phe Ala Ile Ala Thr Ala Gly
        115                 120                 125             
Ala Asn Glu Gly Thr Pro Asn Lys Glu Lys Tyr Arg Arg Met Ser Leu
    130                 135                 140                 
Ala Ser Ala Gly Phe Pro Pro Asp Gln Arg Asn Gly Asp Lys Glu Phe
145                 150                 155                 160 
Val Ile Arg Arg Ala Ala Thr Asn Arg Val Leu Asn Val Leu Arg His
                165                 170                 175     
Trp Val Ser Lys His Ser Gln Asp Phe Glu Thr Asn Asp Glu Leu Lys
            180                 185                 190         
Cys Lys Val Ile Gly Phe Leu Glu Glu Val Met His Asp Pro Glu Leu
        195                 200                 205             
Leu Thr Gln Glu Arg Lys Ala Ala Ala Asn Ile Ile Arg Thr Leu Thr
    210                 215                 220                 
Gln Glu Asp Pro Gly Asp Asn Gln Ile Thr Leu Glu Glu Ile Thr Gln
225                 230                 235                 240 
Met Ala Glu Gly Val Lys Ala Glu Pro Phe Glu Asn His Ser Ala Leu
                245                 250                 255     
Glu Ile Ala Glu Gln Leu Thr Leu Leu Asp His Leu Val Phe Lys Lys
            260                 265                 270         
Ile Pro Tyr Glu Glu Phe Phe Gly Gln Gly Trp Met Lys Leu Glu Lys
        275                 280                 285             
Asn Glu Arg Thr Pro Tyr Ile Met Lys Thr Thr Lys His Phe Asn Asp
    290                 295                 300                 
Ile Ser Asn Leu Ile Ala Ser Glu Ile Ile Arg Asn Glu Asp Ile Asn
305                 310                 315                 320 
Ala Arg Val Ser Ala Ile Glu Lys Trp Val Ala Val Ala Asp Ile Cys
                325                 330                 335     
Arg Cys Leu His Asn Tyr Asn Ala Val Leu Glu Ile Thr Ser Ser Met
            340                 345                 350         
Asn Arg Ser Ala Ile Phe Arg Leu Lys Lys Thr Trp Leu Lys Val Ser
        355                 360                 365             
Lys Gln Thr Lys Ala Leu Ile Asp Lys Leu Gln Lys Leu Val Ser Ser
    370                 375                 380                 
Glu Gly Arg Phe Lys Asn Leu Arg Glu Ala Leu Lys Asn Cys Asp Pro
385                 390                 395                 400 
Pro Cys Val Pro Tyr Leu Gly Met Tyr Leu Thr Asp Leu Ala Phe Ile
                405                 410                 415     
Glu Glu Gly Thr Pro Asn Tyr Thr Glu Asp Gly Leu Val Asn Phe Ser
            420                 425                 430         
Lys Met Arg Met Ile Ser His Ile Ile Arg Glu Ile Arg Gln Phe Gln
        435                 440                 445             
Gln Thr Ala Tyr Lys Ile Glu His Gln Ala Lys Val Thr Gln Tyr Leu
    450                 455                 460                 
Leu Asp Gln Ser Phe Val Met Asp Glu Glu Ser Leu Tyr Glu Ser Ser
465                 470                 475                 480 
Leu Arg Ile Glu Pro Lys Leu Pro Thr
                485                 


<210> 2100
<211> 476
<212> PRT
<213> Homo sapiens

<400> 2100
Met Gly Ser Lys Met Asn Leu Ile Glu His Ser His Leu Pro Thr Thr
 1               5                  10                  15      
Asp Glu Phe Ser Phe Ser Glu Asn Leu Phe Gly Val Leu Thr Glu Gln
            20                  25                  30          
Val Ala Gly Pro Leu Gly Gln Asn Leu Glu Val Glu Pro Tyr Ser Gln
        35                  40                  45              
Tyr Ser Asn Val Gln Phe Pro Gln Val Gln Pro Gln Ile Ser Ser Ser
    50                  55                  60                  
Ser Tyr Tyr Ser Asn Leu Gly Phe Tyr Pro Gln Gln Pro Glu Glu Trp
65                  70                  75                  80  
Tyr Ser Pro Gly Ile Tyr Glu Leu Arg Arg Met Pro Ala Glu Thr Leu
                85                  90                  95      
Tyr Gln Gly Glu Thr Glu Val Ala Glu Met Pro Val Thr Lys Lys Pro
            100                 105                 110         
Arg Met Gly Ala Ser Ala Gly Arg Ile Lys Gly Asp Glu Leu Cys Val
        115                 120                 125             
Val Cys Gly Asp Arg Ala Ser Gly Tyr His Tyr Asn Ala Leu Thr Cys
    130                 135                 140                 
Glu Gly Cys Lys Gly Phe Phe Arg Arg Ser Ile Thr Lys Asn Ala Val
145                 150                 155                 160 
Tyr Lys Cys Lys Asn Gly Gly Asn Cys Val Met Asp Met Tyr Met Arg
                165                 170                 175     
Arg Lys Cys Gln Glu Cys Arg Leu Arg Lys Cys Lys Glu Met Gly Met
            180                 185                 190         
Leu Ala Glu Cys Met Tyr Thr Gly Leu Leu Thr Glu Ile Gln Cys Lys
        195                 200                 205             
Ser Lys Arg Leu Arg Lys Asn Val Lys Gln His Ala Asp Gln Thr Val
    210                 215                 220                 
Asn Glu Asp Ser Glu Gly Arg Asp Leu Arg Gln Val Thr Ser Thr Thr
225                 230                 235                 240 
Lys Ser Cys Arg Glu Lys Thr Glu Leu Thr Pro Asp Gln Gln Thr Leu
                245                 250                 255     
Leu His Phe Ile Met Asp Ser Tyr Asn Lys Gln Arg Met Pro Gln Glu
            260                 265                 270         
Ile Thr Asn Lys Ile Leu Lys Glu Glu Phe Ser Ala Glu Glu Asn Phe
        275                 280                 285             
Leu Ile Leu Thr Glu Met Ala Thr Asn His Val Gln Val Leu Val Glu
    290                 295                 300                 
Phe Thr Lys Lys Leu Pro Gly Phe Gln Thr Leu Asp His Glu Asp Gln
305                 310                 315                 320 
Ile Ala Leu Leu Lys Gly Ser Ala Val Glu Ala Met Phe Leu Arg Ser
                325                 330                 335     
Ala Glu Ile Phe Asn Lys Lys Leu Pro Ser Gly His Ser Asp Leu Leu
            340                 345                 350         
Glu Glu Arg Ile Arg Asn Ser Gly Ile Ser Asp Glu Tyr Ile Thr Pro
        355                 360                 365             
Met Phe Ser Phe Tyr Lys Ser Ile Gly Glu Leu Lys Met Thr Gln Glu
    370                 375                 380                 
Glu Tyr Ala Leu Leu Thr Ala Ile Val Ile Leu Ser Pro Asp Arg Gln
385                 390                 395                 400 
Tyr Ile Lys Asp Arg Glu Ala Val Glu Lys Leu Gln Glu Pro Leu Leu
                405                 410                 415     
Asp Val Leu Gln Lys Leu Cys Lys Ile His Gln Pro Glu Asn Pro Gln
            420                 425                 430         
His Phe Ala Cys Leu Leu Gly Arg Leu Thr Glu Leu Arg Thr Phe Asn
        435                 440                 445             
His His His Ala Glu Met Leu Met Ser Trp Arg Val Asn Asp His Lys
    450                 455                 460                 
Phe Thr Pro Leu Leu Cys Glu Ile Trp Asp Val Gln
465                 470                 475     


<210> 2101
<211> 97
<212> PRT
<213> Homo sapiens

<400> 2101
Met Thr Lys Gly Thr Ser Leu Phe Gly Lys Arg Arg Asn Lys Thr His
 1               5                  10                  15      
Thr Leu Cys Cys Arg Arg Gly Ser Lys Ala Tyr His Leu Gln Lys Ser
            20                  25                  30          
Thr Cys Gly Lys Cys Gly Tyr Ala Ala Lys Arg Lys Arg Lys Tyr Asn
        35                  40                  45              
Trp Ser Ala Lys Ala Lys Arg Gln Asn Thr Thr Gly Thr Gly Gly Met
    50                  55                  60                  
Arg His Leu Lys Ile Val Tyr His Arg Phe Arg His Gly Phe Tyr Glu
65                  70                  75                  80  
Gly Thr Ile Leu Lys Pro Lys Arg Ala Ala Val Ala Ala Ser Ser Ser
                85                  90                  95      
Ser
    


<210> 2102
<211> 532
<212> PRT
<213> Homo sapiens

<400> 2102
Met Asn Lys Ser Thr Cys Leu Met Ala Ala Glu Thr Pro Ser Lys Arg
 1               5                  10                  15      
Trp Arg Leu His Cys Leu Ala Phe Ser Gln Arg Phe Val Arg Ala Gly
            20                  25                  30          
Pro Ala Cys Ser Ser Arg Glu Ala Cys Ser Ser Pro Arg Ala Gly Trp
        35                  40                  45              
Asn Pro Ala Gly Phe Arg Leu Pro Gly Arg Trp Ser Pro Phe Val Ala
    50                  55                  60                  
Leu His Leu Val Cys Gln Ile Arg Glu Ala Leu Lys Leu Arg Ser Gly
65                  70                  75                  80  
His Arg Thr Pro Ser Gly Ala Gly Ser Ser Met Gln Pro Pro Pro Ser
                85                  90                  95      
Leu Cys Gly Arg Ala Leu Val Ala Leu Val Leu Ala Cys Gly Leu Ser
            100                 105                 110         
Arg Ile Trp Gly Glu Glu Arg Gly Phe Pro Pro Asp Arg Ala Thr Pro
        115                 120                 125             
Leu Leu Gln Thr Ala Glu Ile Met Thr Pro Pro Thr Lys Thr Leu Trp
    130                 135                 140                 
Pro Lys Gly Ser Asn Ala Ser Leu Ala Arg Ser Leu Ala Pro Ala Glu
145                 150                 155                 160 
Val Pro Lys Gly Asp Arg Thr Ala Gly Ser Pro Pro Arg Thr Ile Ser
                165                 170                 175     
Pro Pro Pro Cys Gln Gly Pro Ile Glu Ile Lys Glu Thr Phe Lys Tyr
            180                 185                 190         
Ile Asn Thr Val Val Ser Cys Leu Val Phe Val Leu Gly Ile Ile Gly
        195                 200                 205             
Asn Ser Thr Leu Leu Arg Ile Ile Tyr Lys Asn Lys Cys Met Arg Asn
    210                 215                 220                 
Gly Pro Asn Ile Leu Ile Ala Ser Leu Ala Leu Gly Asp Leu Leu His
225                 230                 235                 240 
Ile Val Ile Asp Ile Pro Ile Asn Val Tyr Lys Leu Leu Ala Glu Asp
                245                 250                 255     
Trp Pro Phe Gly Ala Glu Met Cys Lys Leu Val Pro Phe Ile Gln Lys
            260                 265                 270         
Ala Ser Val Gly Ile Thr Val Leu Ser Leu Cys Ala Leu Ser Ile Asp
        275                 280                 285             
Arg Tyr Arg Ala Val Ala Ser Trp Ser Arg Ile Lys Gly Ile Gly Val
    290                 295                 300                 
Pro Lys Trp Thr Ala Val Glu Ile Val Leu Ile Trp Val Val Ser Val
305                 310                 315                 320 
Val Leu Ala Val Pro Glu Ala Ile Gly Phe Asp Ile Ile Thr Met Asp
                325                 330                 335     
Tyr Lys Gly Ser Tyr Leu Arg Ile Cys Leu Leu His Pro Val Gln Lys
            340                 345                 350         
Thr Ala Phe Met Gln Phe Tyr Lys Thr Ala Lys Asp Trp Trp Leu Phe
        355                 360                 365             
Ser Phe Tyr Phe Cys Leu Pro Leu Ala Ile Thr Ala Phe Phe Tyr Thr
    370                 375                 380                 
Leu Met Thr Cys Glu Met Leu Arg Lys Lys Ser Gly Met Gln Ile Ala
385                 390                 395                 400 
Leu Asn Asp His Leu Lys Gln Arg Arg Glu Val Ala Lys Thr Val Phe
                405                 410                 415     
Cys Leu Val Leu Val Phe Ala Leu Cys Trp Leu Pro Leu His Leu Ser
            420                 425                 430         
Arg Ile Leu Lys Leu Thr Leu Tyr Asn Gln Asn Asp Pro Asn Arg Cys
        435                 440                 445             
Glu Leu Leu Ser Phe Leu Leu Val Leu Asp Tyr Ile Gly Ile Asn Met
    450                 455                 460                 
Ala Ser Leu Asn Ser Cys Ile Asn Pro Ile Ala Leu Tyr Leu Val Ser
465                 470                 475                 480 
Lys Arg Phe Lys Asn Cys Phe Lys Ser Cys Leu Cys Cys Trp Cys Gln
                485                 490                 495     
Ser Phe Glu Glu Lys Gln Ser Leu Glu Glu Lys Gln Ser Cys Leu Lys
            500                 505                 510         
Phe Lys Ala Asn Asp His Gly Tyr Asp Asn Phe Arg Ser Ser Asn Lys
        515                 520                 525             
Tyr Ser Ser Ser
    530         


<210> 2103
<211> 4640
<212> PRT
<213> Homo sapiens

<400> 2103
Met Pro Val Pro Asp Gly Ser Val Ala Ala Ala Gly Leu Gly Leu Gly
 1               5                  10                  15      
Leu Pro Ala Ala Asp Ser Arg Gly His Tyr Gln Leu Leu Leu Ser Gly
            20                  25                  30          
Arg Ala Leu Ala Asp Arg Tyr Arg Arg Ile Tyr Thr Ala Ala Leu Asn
        35                  40                  45              
Asp Arg Asp Gln Gly Gly Gly Ser Ala Gly His Pro Ala Ser Arg Asn
    50                  55                  60                  
Lys Lys Ile Leu Asn Lys Lys Lys Leu Lys Arg Lys Gln Lys Ser Lys
65                  70                  75                  80  
Ser Lys Val Lys Thr Arg Ser Lys Ser Glu Asn Leu Glu Asn Thr Val
                85                  90                  95      
Ile Ile Pro Asp Ile Lys Leu His Ser Asn Pro Ser Ala Phe Asn Ile
            100                 105                 110         
Tyr Cys Asn Val Arg His Cys Val Leu Glu Trp Gln Lys Lys Glu Ile
        115                 120                 125             
Ser Leu Ala Ala Ala Ser Lys Asn Ser Val Gln Ser Gly Glu Ser Asp
    130                 135                 140                 
Ser Asp Glu Glu Glu Glu Ser Lys Glu Pro Pro Ile Lys Leu Pro Lys
145                 150                 155                 160 
Ile Ile Glu Val Gly Leu Cys Glu Val Phe Glu Leu Ile Lys Glu Thr
                165                 170                 175     
Arg Phe Ser His Pro Ser Leu Cys Leu Arg Ser Leu Gln Ala Leu Leu
            180                 185                 190         
Asn Val Leu Gln Gly Gln Gln Pro Glu Gly Leu Gln Ser Glu Pro Pro
        195                 200                 205             
Glu Val Leu Glu Ser Leu Phe Gln Leu Leu Leu Glu Ile Thr Val Arg
    210                 215                 220                 
Ser Thr Gly Met Asn Asp Ser Thr Gly Gln Ser Leu Thr Ala Leu Ser
225                 230                 235                 240 
Cys Ala Cys Leu Phe Ser Leu Val Ala Ser Trp Gly Glu Thr Gly Arg
                245                 250                 255     
Thr Leu Gln Ala Ile Ser Ala Ile Leu Thr Asn Asn Gly Ser His Ala
            260                 265                 270         
Cys Gln Thr Ile Gln Val Pro Thr Ile Leu Asn Ser Leu Gln Arg Ser
        275                 280                 285             
Val Gln Ala Val Leu Val Gly Lys Ile Gln Ile Gln Asp Trp Phe Ser
    290                 295                 300                 
Asn Gly Ile Lys Lys Ala Ala Leu Met His Lys Trp Pro Leu Lys Glu
305                 310                 315                 320 
Ile Ser Val Asp Glu Asp Asp Gln Cys Leu Leu Gln Asn Asp Gly Phe
                325                 330                 335     
Phe Leu Tyr Leu Leu Cys Lys Asp Gly Leu Tyr Lys Ile Gly Ser Gly
            340                 345                 350         
Tyr Ser Gly Thr Val Arg Gly His Ile Tyr Asn Ser Thr Ser Arg Ile
        355                 360                 365             
Arg Asn Arg Lys Glu Lys Lys Ser Trp Leu Gly Tyr Ala Gln Gly Tyr
    370                 375                 380                 
Leu Leu Tyr Arg Asp Val Asn Asn His Ser Met Thr Ala Ile Arg Ile
385                 390                 395                 400 
Ser Pro Glu Thr Leu Glu Gln Asp Gly Thr Val Met Leu Pro Asp Cys
                405                 410                 415     
His Thr Glu Gly Gln Asn Ile Leu Phe Thr Asp Gly Glu Tyr Ile Asn
            420                 425                 430         
Gln Ile Ala Ala Ser Arg Asp Asp Gly Phe Val Val Arg Ile Phe Ala
        435                 440                 445             
Thr Ser Thr Glu Pro Val Leu Gln Gln Glu Leu Gln Leu Lys Leu Ala
    450                 455                 460                 
Arg Lys Cys Leu His Ala Cys Gly Ile Ser Leu Phe Asp Leu Glu Lys
465                 470                 475                 480 
Asp Leu His Ile Ile Ser Thr Gly Phe Asp Glu Glu Ser Ala Ile Leu
                485                 490                 495     
Gly Ala Gly Arg Glu Phe Ala Leu Met Lys Thr Ala Asn Gly Lys Ile
            500                 505                 510         
Tyr Tyr Thr Gly Lys Tyr Gln Ser Leu Gly Ile Lys Gln Gly Gly Pro
        515                 520                 525             
Ser Ala Gly Lys Trp Val Glu Leu Pro Ile Thr Lys Ser Pro Lys Ile
    530                 535                 540                 
Val His Phe Ser Val Gly His Asp Gly Ser His Ala Leu Leu Val Ala
545                 550                 555                 560 
Glu Asp Gly Ser Ile Phe Phe Thr Gly Ser Ala Ser Lys Gly Glu Asp
                565                 570                 575     
Gly Glu Ser Ser Lys Ser Arg Arg Gln Ser Lys Pro Tyr Lys Pro Lys
            580                 585                 590         
Lys Ile Ile Lys Met Glu Gly Lys Ile Val Val Tyr Thr Ala Cys Asn
        595                 600                 605             
Asn Gly Ser Ser Ser Val Ile Ser Lys Asp Gly Glu Leu Tyr Met Phe
    610                 615                 620                 
Gly Lys Asp Ala Ile Tyr Ser Asp Ser Ser Ser Leu Val Thr Asp Leu
625                 630                 635                 640 
Lys Gly His Phe Val Thr Gln Val Ala Met Gly Lys Ala His Thr Cys
                645                 650                 655     
Val Leu Met Lys Asn Gly Glu Val Trp Thr Phe Gly Val Asn Asn Lys
            660                 665                 670         
Gly Gln Cys Gly Arg Asp Thr Gly Ala Met Asn Gln Gly Gly Lys Gly
        675                 680                 685             
Phe Gly Val Glu Asn Met Ala Thr Ala Met Asp Glu Asp Leu Glu Glu
    690                 695                 700                 
Glu Leu Asp Glu Lys Asp Glu Lys Ser Met Met Cys Pro Pro Gly Met
705                 710                 715                 720 
His Lys Trp Lys Leu Glu Gln Cys Met Val Cys Thr Val Cys Gly Asp
                725                 730                 735     
Cys Thr Gly Tyr Gly Ala Ser Cys Val Ser Ser Gly Arg Pro Asp Arg
            740                 745                 750         
Val Pro Gly Gly Ile Cys Gly Cys Gly Ser Gly Glu Ser Gly Cys Ala
        755                 760                 765             
Val Cys Gly Cys Cys Lys Ala Cys Ala Arg Glu Leu Asp Gly Gln Glu
    770                 775                 780                 
Ala Arg Gln Arg Gly Ile Leu Asp Ala Val Lys Glu Met Ile Pro Leu
785                 790                 795                 800 
Asp Leu Leu Leu Ala Val Pro Val Pro Gly Val Asn Ile Glu Glu His
                805                 810                 815     
Leu Gln Leu Arg Gln Glu Glu Lys Arg Gln Arg Val Ile Arg Arg His
            820                 825                 830         
Arg Leu Glu Glu Gly Arg Gly Pro Leu Val Phe Ala Gly Pro Ile Phe
        835                 840                 845             
Met Asn His Arg Glu Gln Ala Leu Ala Arg Leu Arg Ser His Pro Ala
    850                 855                 860                 
Gln Leu Lys His Lys Arg Asp Lys His Lys Asp Gly Ser Gly Glu Arg
865                 870                 875                 880 
Gly Glu Lys Asp Ala Ser Lys Ile Thr Thr Tyr Pro Pro Gly Ser Val
                885                 890                 895     
Arg Phe Asp Cys Glu Leu Arg Ala Val Gln Val Ser Cys Gly Phe His
            900                 905                 910         
His Ser Val Val Leu Met Glu Asn Gly Asp Val Tyr Thr Phe Gly Tyr
        915                 920                 925             
Gly Gln His Gly Gln Leu Gly His Gly Asp Val Asn Ser Arg Gly Cys
    930                 935                 940                 
Pro Thr Leu Val Gln Ala Leu Pro Gly Pro Ser Thr Gln Val Thr Ala
945                 950                 955                 960 
Gly Ser Asn His Thr Ala Val Leu Leu Met Asp Gly Gln Val Phe Thr
                965                 970                 975     
Phe Gly Ser Phe Ser Lys Gly Gln Leu Gly Arg Pro Ile Leu Asp Val
            980                 985                 990         
Pro Tyr Trp Asn Ala Lys Pro Ala Pro Met Pro Asn Ile Gly Ser Lys
        995                 1000                1005            
Tyr Gly Arg Lys Ala Thr Trp Ile Gly Ala Ser Gly Asp Gln Thr Phe
    1010                1015                1020                
Leu Arg Ile Asp Glu Ala Leu Ile Asn Ser His Val Leu Ala Thr Ser
1025                1030                1035                1040
Glu Ile Phe Ala Ser Lys His Ile Ile Gly Leu Val Pro Ala Ser Ile
                1045                1050                1055    
Ser Glu Pro Pro Pro Phe Lys Cys Leu Leu Ile Asn Lys Val Asp Gly
            1060                1065                1070        
Ser Cys Lys Thr Phe Asn Asp Ser Glu Gln Glu Asp Leu Gln Gly Phe
        1075                1080                1085            
Gly Val Cys Leu Asp Pro Val Tyr Asp Val Ile Trp Arg Phe Arg Pro
    1090                1095                1100                
Asn Thr Arg Glu Leu Trp Cys Tyr Asn Ala Val Val Ala Asp Ala Arg
1105                1110                1115                1120
Leu Pro Ser Ala Ala Asp Met Gln Ser Arg Cys Ser Ile Leu Ser Pro
                1125                1130                1135    
Glu Leu Ala Leu Pro Thr Gly Ser Arg Ala Leu Thr Thr Arg Ser His
            1140                1145                1150        
Ala Ala Leu His Ile Leu Gly Cys Leu Asp Thr Leu Ala Ala Met Gln
        1155                1160                1165            
Asp Leu Lys Met Gly Val Ala Ser Thr Glu Glu Glu Thr Gln Ala Val
    1170                1175                1180                
Met Lys Val Tyr Ser Lys Glu Asp Tyr Ser Val Val Asn Arg Phe Glu
1185                1190                1195                1200
Ser His Gly Gly Gly Trp Gly Tyr Ser Ala His Ser Val Glu Ala Ile
                1205                1210                1215    
Arg Phe Ser Ala Asp Thr Asp Ile Leu Leu Gly Gly Leu Gly Leu Phe
            1220                1225                1230        
Gly Gly Arg Gly Glu Tyr Thr Ala Lys Ile Lys Leu Phe Glu Leu Gly
        1235                1240                1245            
Pro Asp Gly Gly Asp His Glu Thr Asp Gly Asp Leu Leu Ala Glu Thr
    1250                1255                1260                
Asp Val Leu Ala Tyr Asp Cys Ala Ala Arg Glu Lys Tyr Ala Met Met
1265                1270                1275                1280
Phe Asp Glu Pro Val Leu Leu Gln Ala Gly Trp Trp Tyr Val Ala Trp
                1285                1290                1295    
Ala Arg Val Ser Gly Pro Ser Ser Asp Cys Gly Ser His Gly Gln Ala
            1300                1305                1310        
Ser Ile Thr Thr Asp Asp Gly Val Val Phe Gln Phe Lys Ser Ser Lys
        1315                1320                1325            
Lys Ser Asn Asn Gly Thr Asp Val Asn Ala Gly Gln Ile Pro Gln Leu
    1330                1335                1340                
Leu Tyr Arg Leu Pro Thr Ser Asp Gly Ser Ala Ser Lys Gly Lys Gln
1345                1350                1355                1360
Gln Thr Ser Glu Pro Val His Ile Leu Lys Arg Ser Phe Ala Arg Thr
                1365                1370                1375    
Val Ser Val Glu Cys Phe Glu Ser Leu Leu Ser Ile Leu His Trp Ser
            1380                1385                1390        
Trp Thr Thr Leu Val Leu Gly Val Glu Glu Leu Arg Gly Leu Lys Gly
        1395                1400                1405            
Phe Gln Phe Thr Ala Thr Leu Leu Asp Leu Glu Arg Leu Arg Phe Val
    1410                1415                1420                
Gly Thr Cys Cys Leu Arg Leu Leu Arg Val Tyr Thr Cys Glu Ile Tyr
1425                1430                1435                1440
Pro Val Ser Ala Thr Gly Lys Ala Val Val Glu Glu Thr Ser Lys Leu
                1445                1450                1455    
Ala Glu Cys Ile Gly Lys Thr Arg Thr Leu Leu Arg Lys Ile Leu Ser
            1460                1465                1470        
Glu Gly Val Asp His Cys Met Val Lys Leu Asp Asn Asp Pro Gln Gly
        1475                1480                1485            
Tyr Leu Ser Gln Pro Leu Ser Leu Leu Glu Ala Val Leu Gln Glu Cys
    1490                1495                1500                
His Asn Thr Phe Thr Ala Cys Phe His Ser Phe Tyr Pro Thr Pro Ala
1505                1510                1515                1520
Leu Gln Trp Ala Cys Leu Cys Asp Leu Leu Asn Cys Leu Asp Gln Asp
                1525                1530                1535    
Ile Gln Glu Ala Asn Phe Lys Thr Ser Ser Ser Arg Leu Leu Ala Ala
            1540                1545                1550        
Val Met Ser Ala Leu Cys His Thr Ser Val Lys Leu Thr Ser Ile Phe
        1555                1560                1565            
Pro Ile Ala Tyr Asp Gly Glu Val Leu Leu Arg Ser Ile Val Lys Gln
    1570                1575                1580                
Val Ser Thr Glu Asn Asp Ser Thr Leu Val His Arg Phe Pro Leu Leu
1585                1590                1595                1600
Val Ala His Met Glu Lys Leu Ser Gln Ser Glu Glu Asn Ile Ser Gly
                1605                1610                1615    
Met Thr Ser Phe Arg Glu Val Leu Glu Lys Met Leu Val Ile Val Val
            1620                1625                1630        
Leu Pro Val Arg Asn Ser Leu Arg Arg Glu Asn Glu Leu Phe Ser Ser
        1635                1640                1645            
His Leu Val Ser Asn Thr Cys Gly Leu Leu Ala Ser Ile Val Ser Glu
    1650                1655                1660                
Leu Thr Ala Ser Ala Leu Gly Ser Glu Val Asp Gly Leu Asn Ser Leu
1665                1670                1675                1680
His Ser Val Lys Ala Ser Ala Asn Arg Phe Thr Lys Thr Ser Gln Gly
                1685                1690                1695    
Arg Ser Trp Asn Thr Gly Asn Gly Ser Pro Asp Ala Ile Cys Phe Ser
            1700                1705                1710        
Val Asp Lys Pro Gly Ile Val Val Val Gly Phe Ser Val Tyr Gly Gly
        1715                1720                1725            
Gly Gly Ile His Glu Tyr Glu Leu Glu Val Leu Val Asp Asp Ser Glu
    1730                1735                1740                
His Ala Gly Asp Ser Thr His Ser His Arg Trp Thr Ser Leu Glu Leu
1745                1750                1755                1760
Val Lys Gly Thr Tyr Thr Thr Asp Asp Ser Pro Ser Asp Ile Ala Glu
                1765                1770                1775    
Ile Arg Leu Asp Lys Val Val Pro Leu Lys Glu Asn Val Lys Tyr Ala
            1780                1785                1790        
Val Arg Leu Arg Asn Tyr Gly Ser Arg Thr Ala Asn Gly Asp Gly Gly
        1795                1800                1805            
Met Thr Thr Val Gln Cys Pro Asp Gly Val Thr Phe Thr Phe Ser Thr
    1810                1815                1820                
Cys Ser Leu Ser Ser Asn Gly Thr Asn Gln Thr Arg Gly Gln Ile Pro
1825                1830                1835                1840
Gln Ile Leu Tyr Tyr Arg Ser Glu Phe Asp Gly Asp Leu Gln Ser Gln
                1845                1850                1855    
Leu Leu Ser Lys Ala Asn Glu Glu Asp Lys Asn Cys Ser Arg Ala Leu
            1860                1865                1870        
Ser Val Val Ser Thr Val Val Arg Ala Ser Lys Asp Leu Leu His Arg
        1875                1880                1885            
Ala Leu Ala Val Asp Ala Asp Asp Ile Pro Glu Leu Leu Ser Ser Ser
    1890                1895                1900                
Ser Leu Phe Ser Met Leu Leu Pro Leu Ile Ile Ala Tyr Ile Gly Pro
1905                1910                1915                1920
Val Ala Ala Ala Ile Pro Lys Val Ala Val Glu Val Phe Gly Leu Val
                1925                1930                1935    
Gln Gln Leu Leu Pro Ser Val Ala Ile Leu Asn Gln Lys Tyr Ala Pro
            1940                1945                1950        
Pro Ala Phe Asn Pro Asn Gln Ser Thr Asp Ser Thr Thr Gly Asn Gln
        1955                1960                1965            
Pro Glu Gln Gly Leu Ser Ala Cys Thr Thr Ser Ser His Tyr Ala Val
    1970                1975                1980                
Ile Glu Ser Glu His Pro Tyr Lys Pro Ala Cys Val Met His Tyr Lys
1985                1990                1995                2000
Val Thr Phe Pro Glu Cys Val Arg Trp Met Thr Ile Glu Phe Asp Pro
                2005                2010                2015    
Gln Cys Gly Thr Ala Gln Ser Glu Asp Val Leu Arg Leu Leu Ile Pro
            2020                2025                2030        
Val Arg Thr Val Gln Asn Ser Gly Tyr Gly Pro Lys Leu Thr Ser Val
        2035                2040                2045            
His Glu Asn Leu Asn Ser Trp Ile Glu Leu Lys Lys Phe Ser Gly Ser
    2050                2055                2060                
Ser Gly Trp Pro Thr Met Val Leu Val Leu Pro Gly Asn Glu Ala Leu
2065                2070                2075                2080
Phe Ser Leu Glu Thr Ala Ser Asp Tyr Val Lys Asp Asp Lys Ala Ser
                2085                2090                2095    
Phe Tyr Gly Phe Lys Cys Phe Ala Ile Gly Tyr Glu Phe Ser Pro Gly
            2100                2105                2110        
Pro Asp Glu Gly Val Ile Gln Leu Glu Lys Glu Leu Ala Asn Leu Gly
        2115                2120                2125            
Gly Val Cys Ala Ala Ala Leu Met Lys Lys Asp Leu Ala Leu Pro Ile
    2130                2135                2140                
Gly Asn Glu Leu Glu Glu Asp Leu Glu Ile Leu Glu Glu Ala Ala Leu
2145                2150                2155                2160
Gln Val Cys Lys Thr His Ser Gly Ile Leu Gly Lys Gly Leu Ala Leu
                2165                2170                2175    
Ser His Ser Pro Thr Ile Leu Glu Ala Leu Glu Gly Asn Leu Pro Leu
            2180                2185                2190        
Gln Ile Gln Ser Asn Glu Gln Ser Phe Leu Asp Asp Phe Ile Ala Cys
        2195                2200                2205            
Val Pro Gly Ser Ser Gly Gly Arg Leu Ala Arg Trp Leu Gln Pro Asp
    2210                2215                2220                
Ser Tyr Ala Asp Pro Gln Lys Thr Ser Leu Ile Leu Asn Lys Asp Asp
2225                2230                2235                2240
Ile Arg Cys Gly Trp Pro Thr Thr Ile Thr Val Gln Thr Lys Asp Gln
                2245                2250                2255    
Tyr Gly Asp Val Val His Val Pro Asn Met Lys Val Glu Val Lys Ala
            2260                2265                2270        
Val Pro Val Ser Gln Lys Lys Met Ser Leu Gln Gln Asp Gln Ala Lys
        2275                2280                2285            
Lys Pro Gln Arg Ile Pro Gly Ser Pro Ala Val Thr Ala Ala Ser Ser
    2290                2295                2300                
Asn Thr Asp Met Thr Tyr Gly Gly Leu Ala Ser Pro Lys Leu Asp Val
2305                2310                2315                2320
Ser Tyr Glu Pro Met Ile Val Lys Glu Ala Arg Tyr Ile Ala Ile Thr
                2325                2330                2335    
Met Met Lys Val Tyr Glu Asn Tyr Ser Phe Glu Glu Leu Arg Phe Ala
            2340                2345                2350        
Ser Pro Thr Pro Lys Arg Pro Ser Glu Asn Met Leu Ile Arg Val Asn
        2355                2360                2365            
Asn Asp Gly Thr Tyr Cys Ala Asn Trp Thr Pro Gly Ala Ile Gly Leu
    2370                2375                2380                
Tyr Thr Leu His Val Thr Ile Asp Gly Ile Glu Ile Asp Ala Gly Leu
2385                2390                2395                2400
Glu Val Lys Val Lys Asp Pro Pro Lys Gly Met Ile Pro Pro Gly Thr
                2405                2410                2415    
Gln Leu Val Lys Pro Lys Ser Glu Pro Gln Pro Asn Lys Val Arg Lys
            2420                2425                2430        
Phe Val Ala Lys Asp Ser Ala Gly Leu Arg Ile Arg Ser His Pro Ser
        2435                2440                2445            
Leu Gln Ser Glu Gln Ile Gly Ile Val Lys Val Asn Gly Thr Ile Thr
    2450                2455                2460                
Phe Ile Asp Glu Ile His Asn Asp Asp Gly Val Trp Leu Arg Leu Asn
2465                2470                2475                2480
Asp Glu Thr Ile Lys Lys Tyr Val Pro Asn Met Asn Gly Tyr Thr Glu
                2485                2490                2495    
Ala Trp Cys Leu Ser Phe Asn Gln His Leu Gly Lys Ser Leu Leu Val
            2500                2505                2510        
Pro Val Asp Glu Ser Lys Thr Asn Thr Asp Asp Phe Phe Lys Asp Ile
        2515                2520                2525            
Asn Ser Cys Cys Pro Gln Glu Ala Thr Met Gln Glu Gln Asp Met Pro
    2530                2535                2540                
Phe Leu Arg Gly Gly Pro Gly Met Tyr Lys Val Val Lys Thr Gly Pro
2545                2550                2555                2560
Ser Gly His Asn Ile Arg Ser Cys Pro Asn Leu Arg Gly Ile Pro Ile
                2565                2570                2575    
Gly Met Leu Val Leu Gly Asn Lys Val Lys Ala Val Gly Glu Val Thr
            2580                2585                2590        
Asn Ser Glu Gly Thr Trp Val Gln Leu Asp Gln Asn Ser Met Val Glu
        2595                2600                2605            
Phe Cys Glu Ser Asp Glu Gly Glu Ala Trp Ser Leu Ala Arg Asp Arg
    2610                2615                2620                
Gly Gly Asn Gln Tyr Leu Arg His Glu Asp Glu Gln Ala Leu Leu Asp
2625                2630                2635                2640
Gln Asn Ser Gln Thr Pro Pro Pro Ser Pro Phe Ser Val Gln Ala Phe
                2645                2650                2655    
Asn Lys Gly Ala Ser Cys Ser Ala Gln Gly Phe Asp Tyr Gly Leu Gly
            2660                2665                2670        
Asn Ser Lys Gly Asp Arg Gly Asn Ile Ser Thr Ser Ser Lys Pro Ala
        2675                2680                2685            
Ser Thr Ser Gly Lys Ser Glu Leu Ser Ser Lys His Ser Arg Ser Leu
    2690                2695                2700                
Lys Pro Asp Gly Arg Met Ser Arg Thr Thr Ala Asp Gln Lys Lys Pro
2705                2710                2715                2720
Arg Gly Thr Glu Ser Leu Ser Ala Ser Glu Ser Leu Ile Leu Lys Ser
                2725                2730                2735    
Asp Ala Ala Lys Leu Arg Ser Asp Ser His Ser Arg Ser Leu Ser Pro
            2740                2745                2750        
Asn His Asn Thr Leu Gln Thr Leu Lys Ser Asp Gly Arg Met Pro Ser
        2755                2760                2765            
Ser Ser Arg Ala Glu Ser Pro Gly Pro Gly Ser Arg Leu Ser Ser Pro
    2770                2775                2780                
Lys Pro Lys Thr Leu Pro Ala Asn Arg Ser Ser Pro Ser Gly Ala Ser
2785                2790                2795                2800
Ser Pro Arg Ser Ser Ser Pro His Asp Lys Asn Leu Pro Gln Lys Ser
                2805                2810                2815    
Thr Ala Pro Val Lys Thr Lys Leu Asp Pro Pro Arg Glu Arg Ser Lys
            2820                2825                2830        
Ser Asp Ser Tyr Thr Leu Asp Pro Asp Thr Leu Arg Lys Lys Lys Met
        2835                2840                2845            
Pro Leu Thr Glu Pro Leu Arg Gly Arg Ser Thr Ser Pro Lys Pro Lys
    2850                2855                2860                
Ser Val Pro Lys Asp Ser Thr Asp Ser Pro Gly Ser Glu Asn Arg Ala
2865                2870                2875                2880
Pro Ser Pro His Val Val Gln Glu Asn Leu His Ser Glu Val Val Glu
                2885                2890                2895    
Val Cys Thr Ser Ser Thr Leu Lys Thr Asn Ser Leu Thr Asp Ser Thr
            2900                2905                2910        
Cys Asp Asp Ser Ser Glu Phe Lys Ser Val Asp Glu Gly Ser Asn Lys
        2915                2920                2925            
Val His Phe Ser Ile Gly Lys Ala Pro Leu Lys Asp Glu Gln Glu Met
    2930                2935                2940                
Arg Ala Ser Pro Lys Ile Ser Arg Lys Cys Ala Asn Arg His Thr Arg
2945                2950                2955                2960
Pro Lys Lys Glu Lys Ser Ser Phe Leu Phe Lys Gly Asp Gly Ser Lys
                2965                2970                2975    
Pro Leu Glu Pro Ala Lys Gln Ala Met Ser Pro Ser Val Ala Glu Cys
            2980                2985                2990        
Ala Arg Ala Val Phe Ala Ser Phe Leu Trp His Glu Gly Ile Val His
        2995                3000                3005            
Asp Ala Met Ala Cys Ser Ser Phe Leu Lys Phe His Pro Glu Leu Ser
    3010                3015                3020                
Lys Glu His Ala Pro Ile Arg Ser Ser Leu Asn Ser Gln Gln Pro Thr
3025                3030                3035                3040
Glu Glu Lys Glu Thr Lys Leu Lys Asn Arg His Ser Leu Glu Ile Ser
                3045                3050                3055    
Ser Ala Leu Asn Met Phe Asn Ile Ala Pro His Gly Pro Asp Ile Ser
            3060                3065                3070        
Lys Met Gly Ser Ile Asn Lys Asn Lys Val Leu Ser Met Leu Lys Glu
        3075                3080                3085            
Pro Pro Leu His Glu Lys Cys Glu Asp Gly Lys Thr Glu Thr Thr Phe
    3090                3095                3100                
Glu Met Ser Met His Asn Thr Met Lys Ser Lys Ser Pro Leu Pro Leu
3105                3110                3115                3120
Thr Leu Gln His Leu Val Ala Phe Trp Glu Asp Ile Ser Leu Ala Thr
                3125                3130                3135    
Ile Lys Ala Ala Ser Gln Asn Met Ile Phe Pro Ser Pro Gly Ser Cys
            3140                3145                3150        
Ala Val Leu Lys Lys Lys Glu Cys Glu Lys Glu Asn Lys Lys Ser Lys
        3155                3160                3165            
Lys Glu Lys Lys Lys Lys Glu Lys Ala Glu Val Arg Pro Arg Gly Asn
    3170                3175                3180                
Leu Phe Gly Glu Met Ala Gln Leu Ala Val Gly Gly Pro Glu Lys Asp
3185                3190                3195                3200
Thr Ile Cys Glu Leu Cys Gly Glu Ser His Pro Tyr Pro Val Thr Tyr
                3205                3210                3215    
His Met Arg Gln Ala His Pro Gly Cys Gly Arg Tyr Ala Gly Gly Gln
            3220                3225                3230        
Gly Tyr Asn Ser Ile Gly His Phe Cys Gly Gly Trp Ala Gly Asn Cys
        3235                3240                3245            
Gly Asp Gly Gly Ile Gly Gly Ser Thr Trp Tyr Leu Val Cys Asp Arg
    3250                3255                3260                
Cys Arg Glu Lys Tyr Leu Arg Glu Lys Gln Ala Ala Ala Arg Glu Lys
3265                3270                3275                3280
Val Lys Gln Ser Arg Arg Lys Pro Met Gln Val Lys Thr Pro Arg Ala
                3285                3290                3295    
Leu Pro Thr Met Glu Ala His Gln Val Ile Lys Ala Asn Ala Leu Phe
            3300                3305                3310        
Leu Leu Ser Leu Ser Ser Ala Ala Glu Pro Ser Ile Leu Cys Tyr His
        3315                3320                3325            
Pro Ala Lys Pro Phe Gln Ser Gln Leu Pro Ser Val Lys Glu Gly Ile
    3330                3335                3340                
Ser Glu Asp Leu Pro Val Lys Met Pro Cys Leu Tyr Leu Gln Thr Leu
3345                3350                3355                3360
Ala Arg His His His Glu Asn Phe Val Gly Tyr Gln Asp Asp Asn Leu
                3365                3370                3375    
Phe Gln Asp Glu Met Arg Tyr Leu Arg Ser Thr Ser Val Pro Ala Pro
            3380                3385                3390        
Tyr Ile Ser Val Thr Pro Asp Ala Ser Pro Asn Val Phe Glu Glu Pro
        3395                3400                3405            
Glu Ser Asn Met Lys Ser Met Pro Pro Ser Leu Glu Thr Ser Pro Ile
    3410                3415                3420                
Thr Asp Thr Asp Leu Ala Lys Arg Thr Val Phe Gln Arg Ser Tyr Ser
3425                3430                3435                3440
Val Val Ala Ser Glu Tyr Asp Lys Gln His Ser Ile Leu Pro Ala Arg
                3445                3450                3455    
Val Lys Ala Ile Pro Arg Arg Arg Val Asn Ser Gly Asp Thr Glu Val
            3460                3465                3470        
Gly Ser Ser Leu Leu Arg His Pro Ser Pro Glu Leu Ser Arg Leu Ile
        3475                3480                3485            
Ser Ala His Ser Ser Leu Ser Lys Gly Glu Arg Asn Phe Gln Trp Pro
    3490                3495                3500                
Val Leu Ala Phe Val Ile Gln His His Asp Leu Glu Gly Leu Glu Ile
3505                3510                3515                3520
Ala Met Lys Gln Ala Leu Arg Lys Ser Ala Cys Arg Val Phe Ala Met
                3525                3530                3535    
Glu Ala Phe Asn Trp Leu Leu Cys Asn Val Ile Gln Thr Thr Ser Leu
            3540                3545                3550        
His Asp Ile Leu Trp His Phe Val Ala Ser Leu Thr Pro Ala Pro Val
        3555                3560                3565            
Glu Pro Glu Glu Glu Glu Asp Glu Glu Asn Lys Thr Ser Lys Glu Asn
    3570                3575                3580                
Ser Glu Gln Glu Lys Asp Thr Arg Val Cys Glu His Pro Leu Ser Asp
3585                3590                3595                3600
Ile Val Ile Ala Gly Glu Ala Ala His Pro Leu Pro His Thr Phe His
                3605                3610                3615    
Arg Leu Leu Gln Thr Ile Ser Asp Leu Met Met Ser Leu Pro Ser Gly
            3620                3625                3630        
Ser Ser Leu Gln Gln Met Ala Leu Arg Cys Trp Ser Leu Lys Phe Lys
        3635                3640                3645            
Gln Ser Asp His Gln Phe Leu His Gln Ser Asn Val Phe His His Ile
    3650                3655                3660                
Asn Asn Ile Leu Ser Lys Ser Asp Asp Gly Asp Ser Glu Glu Ser Phe
3665                3670                3675                3680
Ser Ile Ser Ile Gln Ser Gly Phe Glu Ala Met Ser Gln Glu Leu Cys
                3685                3690                3695    
Ile Val Met Cys Leu Lys Asp Leu Thr Ser Ile Val Asp Ile Lys Thr
            3700                3705                3710        
Ser Ser Arg Pro Ala Met Ile Gly Ser Leu Thr Asp Gly Ser Thr Glu
        3715                3720                3725            
Thr Phe Trp Glu Ser Gly Asp Glu Asp Lys Asn Lys Thr Lys Asn Ile
    3730                3735                3740                
Thr Ile Asn Cys Val Lys Gly Ile Asn Ala Arg Tyr Val Ser Val His
3745                3750                3755                3760
Val Asp Asn Ser Arg Asp Leu Gly Asn Lys Val Thr Ser Met Thr Phe
                3765                3770                3775    
Leu Thr Gly Lys Ala Val Glu Asp Leu Cys Arg Ile Lys Gln Val Asp
            3780                3785                3790        
Leu Asp Ser Arg His Ile Gly Trp Val Thr Ser Glu Leu Pro Gly Gly
        3795                3800                3805            
Asp Asn His Ile Ile Lys Ile Glu Leu Lys Gly Pro Glu Asn Thr Leu
    3810                3815                3820                
Arg Val Arg Gln Val Lys Val Leu Gly Trp Lys Asp Gly Glu Ser Thr
3825                3830                3835                3840
Lys Ile Ala Gly Gln Ile Ser Ala Ser Val Ala Gln Gln Arg Asn Cys
                3845                3850                3855    
Glu Ala Glu Thr Leu Arg Val Phe Arg Leu Ile Thr Ser Gln Val Phe
            3860                3865                3870        
Gly Lys Leu Ile Ser Gly Asp Ala Glu Pro Thr Pro Glu Gln Glu Glu
        3875                3880                3885            
Lys Ala Leu Leu Ser Ser Pro Glu Gly Glu Glu Lys Val Tyr Asn Ala
    3890                3895                3900                
Thr Ser Asp Ala Asp Leu Lys Glu His Met Val Gly Ile Ile Phe Ser
3905                3910                3915                3920
Arg Ser Lys Leu Thr Asn Leu Gln Lys Gln Val Cys Ala His Ile Val
                3925                3930                3935    
Gln Ala Ile Arg Met Glu Ala Thr Arg Val Arg Glu Glu Trp Glu His
            3940                3945                3950        
Ala Ile Ser Ser Lys Glu Asn Ala Asn Ser Gln Pro Asn Asp Glu Asp
        3955                3960                3965            
Ala Ser Ser Asp Ala Tyr Cys Phe Glu Leu Leu Ser Met Val Leu Ala
    3970                3975                3980                
Leu Ser Gly Ser Asn Val Gly Arg Gln Tyr Leu Ala Gln Gln Leu Thr
3985                3990                3995                4000
Leu Leu Gln Asp Leu Phe Ser Leu Leu His Thr Ala Ser Pro Arg Val
                4005                4010                4015    
Gln Arg Gln Val Thr Ser Leu Leu Arg Arg Val Leu Pro Glu Val Thr
            4020                4025                4030        
Pro Ser Arg Leu Ala Ser Ile Ile Gly Val Lys Ser Leu Pro Pro Ala
        4035                4040                4045            
Asp Ile Ser Asp Ile Ile His Ser Thr Glu Lys Gly Asp Trp Asn Lys
    4050                4055                4060                
Leu Gly Ile Leu Asp Met Phe Leu Gly Cys Ile Ala Lys Ala Leu Thr
4065                4070                4075                4080
Val Gln Leu Lys Ala Lys Gly Thr Thr Ile Thr Gly Thr Ala Gly Thr
                4085                4090                4095    
Thr Val Gly Lys Gly Val Thr Thr Val Thr Leu Pro Met Ile Phe Asn
            4100                4105                4110        
Ser Ser Tyr Leu Arg Arg Gly Glu Ser His Trp Trp Met Lys Gly Ser
        4115                4120                4125            
Thr Pro Thr Gln Ile Ser Glu Ile Ile Ile Lys Leu Ile Lys Asp Met
    4130                4135                4140                
Ala Ala Gly His Leu Ser Glu Ala Trp Ser Arg Val Thr Lys Asn Ala
4145                4150                4155                4160
Ile Ala Glu Thr Ile Ile Ala Leu Thr Lys Met Glu Glu Glu Phe Arg
                4165                4170                4175    
Ser Pro Val Arg Cys Ile Ala Thr Thr Arg Leu Trp Leu Ala Leu Ala
            4180                4185                4190        
Ser Leu Cys Val Leu Asp Gln Asp His Val Asp Arg Leu Ser Ser Gly
        4195                4200                4205            
Arg Trp Met Gly Lys Asp Gly Gln Gln Lys Gln Met Pro Met Cys Asp
    4210                4215                4220                
Asn His Asp Asp Gly Glu Thr Ala Ala Ile Ile Leu Cys Asn Val Cys
4225                4230                4235                4240
Gly Asn Leu Cys Thr Asp Cys Asp Arg Phe Leu His Leu His Arg Arg
                4245                4250                4255    
Thr Lys Thr His Gln Arg Gln Val Phe Lys Glu Glu Glu Glu Ala Ile
            4260                4265                4270        
Lys Val Asp Leu His Glu Gly Cys Gly Arg Thr Lys Leu Phe Trp Leu
        4275                4280                4285            
Met Ala Leu Ala Asp Ser Lys Thr Met Lys Ala Met Val Glu Phe Arg
    4290                4295                4300                
Glu His Thr Gly Lys Pro Thr Thr Ser Ser Ser Glu Ala Cys Arg Phe
4305                4310                4315                4320
Cys Gly Ser Arg Ser Gly Thr Glu Leu Ser Ala Val Gly Ser Val Cys
                4325                4330                4335    
Ser Asp Ala Asp Cys Gln Glu Tyr Ala Lys Ile Ala Cys Ser Lys Thr
            4340                4345                4350        
His Pro Cys Gly His Pro Cys Gly Gly Val Lys Asn Glu Glu His Cys
        4355                4360                4365            
Leu Pro Cys Leu His Gly Cys Asp Lys Ser Ala Thr Ser Leu Lys Gln
    4370                4375                4380                
Asp Ala Asp Asp Met Cys Met Ile Cys Phe Thr Glu Ala Leu Ser Ala
4385                4390                4395                4400
Ala Pro Ala Ile Gln Leu Asp Cys Ser His Ile Phe His Leu Gln Cys
                4405                4410                4415    
Cys Arg Arg Val Leu Glu Asn Arg Trp Leu Gly Pro Arg Ile Thr Phe
            4420                4425                4430        
Gly Phe Ile Ser Cys Pro Ile Cys Lys Asn Lys Ile Asn His Ile Val
        4435                4440                4445            
Leu Lys Asp Leu Leu Asp Pro Ile Lys Glu Leu Tyr Glu Asp Val Arg
    4450                4455                4460                
Arg Lys Ala Leu Met Arg Leu Glu Tyr Glu Gly Leu His Lys Ser Glu
4465                4470                4475                4480
Ala Ile Thr Thr Pro Gly Val Arg Phe Tyr Asn Asp Pro Ala Gly Tyr
                4485                4490                4495    
Ala Met Asn Arg Tyr Ala Tyr Tyr Val Cys Tyr Lys Cys Arg Lys Ala
            4500                4505                4510        
Tyr Phe Gly Gly Glu Ala Arg Cys Asp Ala Glu Ala Gly Arg Gly Asp
        4515                4520                4525            
Asp Tyr Asp Pro Arg Glu Leu Ile Cys Gly Ala Cys Ser Asp Val Ser
    4530                4535                4540                
Arg Ala Gln Met Cys Pro Lys His Gly Thr Asp Phe Leu Glu Tyr Lys
4545                4550                4555                4560
Cys Arg Tyr Cys Cys Ser Val Ala Val Phe Phe Cys Phe Gly Thr Thr
                4565                4570                4575    
His Phe Cys Asn Ala Cys His Asp Asp Phe Gln Arg Met Thr Ser Ile
            4580                4585                4590        
Pro Lys Glu Glu Leu Pro His Cys Pro Ala Gly Pro Lys Gly Lys Gln
        4595                4600                4605            
Leu Glu Gly Thr Glu Cys Pro Leu His Val Val His Pro Pro Thr Gly
    4610                4615                4620                
Glu Glu Phe Ala Leu Gly Cys Gly Val Cys Arg Asn Ala His Thr Phe
4625                4630                4635                4640


<210> 2104
<211> 109
<212> PRT
<213> Homo sapiens

<400> 2104
Met Ala Gly Ala Leu Val Arg Lys Ala Ala Asp Tyr Val Arg Ser Lys
 1               5                  10                  15      
Asp Phe Arg Asp Tyr Leu Met Arg Thr His Phe Trp Gly Pro Val Ala
            20                  25                  30          
Asn Trp Gly Leu Pro Ile Ala Ala Ile Asn Asp Met Lys Lys Ser Pro
        35                  40                  45              
Glu Ile Ile Ser Gly Arg Met Thr Phe Ala Leu Cys Cys Tyr Ser Leu
    50                  55                  60                  
Thr Phe Met Arg Phe Ala Tyr Lys Val Gln Pro Arg Asn Trp Leu Leu
65                  70                  75                  80  
Phe Ala Cys His Ala Thr Asn Glu Val Ala Gln Leu Ile Gln Gly Gly
                85                  90                  95      
Arg Leu Ile Lys His Glu Met Thr Lys Thr Ala Ser Ala
            100                 105                 


<210> 2105
<211> 1191
<212> PRT
<213> Homo sapiens

<400> 2105
Met Pro Gly Thr Pro Gly Ser Leu Glu Met Gly Leu Leu Thr Phe Arg
 1               5                  10                  15      
Asp Val Ala Ile Glu Phe Ser Pro Glu Glu Trp Gln Cys Leu Asp Thr
            20                  25                  30          
Ala Gln Gln Asn Leu Tyr Arg Asn Val Met Leu Glu Asn Tyr Arg Asn
        35                  40                  45              
Leu Ala Phe Leu Gly Ile Ala Leu Ser Lys Pro Asp Leu Ile Thr Tyr
    50                  55                  60                  
Leu Glu Gln Gly Lys Glu Pro Trp Asn Met Lys Gln His Glu Met Val
65                  70                  75                  80  
Asp Glu Pro Thr Gly Ile Cys Pro His Phe Pro Gln Asp Phe Trp Pro
                85                  90                  95      
Glu Gln Ser Met Glu Asp Ser Phe Gln Lys Val Leu Leu Arg Lys His
            100                 105                 110         
Glu Lys Cys Gly His Glu Asn Leu Gln Leu Arg Lys Gly Cys Lys Ser
        115                 120                 125             
Val Asp Glu Cys Lys Val His Lys Glu Gly Tyr Asn Lys Leu Asn Gln
    130                 135                 140                 
Cys Leu Thr Thr Ala Gln Ser Lys Val Phe Gln Cys Gly Lys Tyr Leu
145                 150                 155                 160 
Lys Val Phe Tyr Lys Phe Leu Asn Ser Asn Arg His Thr Ile Arg His
                165                 170                 175     
Thr Gly Lys Lys Cys Phe Lys Cys Lys Lys Cys Val Lys Ser Phe Cys
            180                 185                 190         
Ile Arg Leu His Lys Thr Gln His Lys Cys Val Tyr Ile Thr Glu Lys
        195                 200                 205             
Ser Cys Lys Cys Lys Glu Cys Glu Lys Thr Phe His Trp Ser Ser Thr
    210                 215                 220                 
Leu Thr Asn His Lys Glu Ile His Thr Glu Asp Lys Pro Tyr Lys Cys
225                 230                 235                 240 
Glu Glu Cys Gly Lys Ala Phe Lys Gln Leu Ser Thr Leu Thr Thr His
                245                 250                 255     
Lys Ile Ile Cys Ala Lys Glu Lys Ile Tyr Lys Cys Glu Glu Cys Gly
            260                 265                 270         
Lys Ala Phe Leu Trp Ser Ser Thr Leu Thr Arg His Lys Arg Ile His
        275                 280                 285             
Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Ser
    290                 295                 300                 
His Ser Ser Thr Leu Ala Lys His Lys Arg Ile His Thr Gly Glu Lys
305                 310                 315                 320 
Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Ser Arg Ser Ser Thr
                325                 330                 335     
Leu Ala Lys His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys
            340                 345                 350         
Lys Glu Cys Gly Lys Ala Phe Ser Asn Ser Ser Thr Leu Ala Asn His
        355                 360                 365             
Lys Ile Thr His Thr Glu Glu Lys Pro Tyr Lys Cys Lys Glu Cys Asp
    370                 375                 380                 
Lys Ala Phe Lys Arg Leu Ser Thr Leu Thr Lys His Lys Ile Ile His
385                 390                 395                 400 
Ala Gly Glu Lys Leu Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn
                405                 410                 415     
Arg Ser Ser Asn Leu Thr Ile His Lys Phe Ile His Thr Gly Glu Lys
            420                 425                 430         
Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Trp Ser Ser Ser
        435                 440                 445             
Leu Thr Lys His Lys Arg Phe His Thr Arg Glu Lys Pro Phe Lys Cys
    450                 455                 460                 
Lys Glu Cys Gly Lys Ala Phe Ile Trp Ser Ser Thr Leu Thr Arg His
465                 470                 475                 480 
Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly
                485                 490                 495     
Lys Ala Phe Arg Gln Ser Ser Thr Leu Thr Lys His Lys Ile Ile His
            500                 505                 510         
Thr Gly Glu Lys Pro Tyr Lys Phe Glu Glu Cys Gly Lys Ala Phe Arg
        515                 520                 525             
Gln Ser Leu Thr Leu Asn Lys His Lys Ile Ile His Ser Arg Glu Lys
    530                 535                 540                 
Pro Tyr Lys Cys Lys Glu Cys Gly Lys Ala Phe Lys Gln Phe Ser Thr
545                 550                 555                 560 
Leu Thr Thr His Lys Ile Ile His Ala Gly Lys Lys Leu Tyr Lys Cys
                565                 570                 575     
Glu Glu Cys Gly Lys Ala Phe Asn His Ser Ser Ser Leu Ser Thr His
            580                 585                 590         
Lys Ile Ile His Thr Gly Glu Lys Ser Tyr Lys Cys Glu Glu Cys Gly
        595                 600                 605             
Lys Ala Phe Leu Trp Ser Ser Thr Leu Arg Arg His Lys Arg Ile His
    610                 615                 620                 
Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Ser
625                 630                 635                 640 
His Ser Ser Ala Leu Ala Lys His Lys Arg Ile His Thr Gly Glu Lys
                645                 650                 655     
Pro Tyr Lys Cys Lys Glu Cys Gly Lys Ala Phe Ser Asn Ser Ser Thr
            660                 665                 670         
Leu Ala Asn His Lys Ile Thr His Thr Glu Glu Lys Pro Tyr Lys Cys
        675                 680                 685             
Lys Glu Cys Asp Lys Thr Phe Lys Arg Leu Ser Thr Leu Thr Lys His
    690                 695                 700                 
Lys Ile Ile His Ala Gly Glu Lys Leu Tyr Lys Cys Glu Glu Cys Gly
705                 710                 715                 720 
Lys Ala Phe Asn Arg Ser Ser Asn Leu Thr Ile His Lys Phe Ile His
                725                 730                 735     
Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn
            740                 745                 750         
Trp Ser Ser Ser Leu Thr Lys His Lys Arg Ile His Thr Arg Glu Lys
        755                 760                 765             
Pro Phe Lys Cys Lys Glu Cys Gly Lys Ala Phe Ile Trp Ser Ser Thr
    770                 775                 780                 
Leu Thr Arg His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys
785                 790                 795                 800 
Glu Glu Cys Gly Lys Ala Phe Ser Arg Ser Ser Thr Leu Thr Lys His
                805                 810                 815     
Lys Thr Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly
            820                 825                 830         
Lys Ala Phe Lys His Ser Ser Ala Leu Ala Lys His Lys Ile Ile His
        835                 840                 845             
Ala Gly Glu Lys Leu Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn
    850                 855                 860                 
Gln Ser Ser Asn Leu Thr Thr His Lys Ile Ile His Thr Lys Glu Lys
865                 870                 875                 880 
Pro Ser Lys Ser Glu Glu Cys Asp Lys Ala Phe Ile Trp Ser Ser Ala
                885                 890                 895     
Leu Thr Glu His Lys Arg Ile His Thr Arg Glu Lys Thr Tyr Lys Cys
            900                 905                 910         
Glu Glu Cys Gly Lys Ala Phe Ser Gln Pro Ser His Leu Thr Thr His
        915                 920                 925             
Lys Arg Met His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly
    930                 935                 940                 
Lys Ala Phe Ser Gln Ser Ser Thr Leu Thr Thr His Lys Ile Ile His
945                 950                 955                 960 
Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Arg
                965                 970                 975     
Lys Ser Ser Thr Leu Thr Glu His Lys Ile Ile His Thr Gly Glu Lys
            980                 985                 990         
Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Ser Gln Ser Ser Thr
        995                 1000                1005            
Leu Thr Arg His Thr Arg Met His Thr Gly Glu Lys Pro Tyr Lys Cys
    1010                1015                1020                
Glu Glu Cys Gly Lys Ala Phe Asn Arg Ser Ser Lys Leu Thr Thr His
1025                1030                1035                1040
Lys Ile Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly
                1045                1050                1055    
Lys Ala Phe Ile Ser Ser Ser Thr Leu Asn Gly His Lys Arg Ile His
            1060                1065                1070        
Thr Arg Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Ser
        1075                1080                1085            
Gln Ser Ser Thr Leu Thr Arg His Lys Arg Leu His Thr Gly Glu Lys
    1090                1095                1100                
Pro Tyr Lys Cys Gly Glu Cys Gly Lys Ala Phe Lys Glu Ser Ser Ala
1105                1110                1115                1120
Leu Thr Lys His Lys Ile Ile His Thr Gly Glu Lys Pro Tyr Lys Cys
                1125                1130                1135    
Glu Lys Cys Gly Lys Ala Phe Asn Gln Ser Ser Ile Leu Thr Asn His
            1140                1145                1150        
Lys Lys Ile His Thr Ile Thr Pro Val Ile Pro Ala Leu Trp Glu Ala
        1155                1160                1165            
Glu Ala Gly Gly Ser Arg Gly Gln Glu Met Glu Thr Ile Leu Ala Asn
    1170                1175                1180                
Thr Val Lys Pro Leu Leu Tyr
1185                1190    


<210> 2106
<211> 719
<212> PRT
<213> Homo sapiens

<400> 2106
Met Met Lys Leu Ile Ile Asn Ser Leu Tyr Lys Asn Lys Glu Ile Phe
 1               5                  10                  15      
Leu Arg Glu Leu Ile Ser Asn Ala Ser Asp Ala Leu Asp Lys Ile Arg
            20                  25                  30          
Leu Ile Ser Leu Thr Asp Glu Asn Ala Leu Ser Gly Asn Glu Glu Leu
        35                  40                  45              
Thr Val Lys Ile Lys Cys Asp Lys Glu Lys Asn Leu Leu His Val Thr
    50                  55                  60                  
Asp Thr Gly Val Gly Met Thr Arg Glu Glu Leu Val Lys Asn Leu Gly
65                  70                  75                  80  
Thr Ile Ala Lys Ser Gly Thr Ser Glu Phe Leu Asn Lys Met Thr Glu
                85                  90                  95      
Ala Gln Glu Asp Gly Gln Ser Thr Ser Glu Leu Ile Gly Gln Phe Gly
            100                 105                 110         
Val Gly Phe Tyr Ser Ala Phe Leu Val Ala Asp Lys Val Ile Val Thr
        115                 120                 125             
Ser Lys His Asn Asn Asp Thr Gln His Ile Trp Glu Ser Asp Ser Asn
    130                 135                 140                 
Glu Phe Ser Val Ile Ala Asp Pro Arg Gly Asn Thr Leu Gly Arg Gly
145                 150                 155                 160 
Thr Thr Ile Thr Leu Val Leu Lys Glu Glu Ala Ser Asp Tyr Leu Glu
                165                 170                 175     
Leu Asp Thr Ile Lys Asn Leu Val Lys Lys Tyr Ser Gln Phe Ile Asn
            180                 185                 190         
Phe Pro Ile Tyr Val Trp Ser Ser Lys Thr Glu Thr Val Glu Glu Pro
        195                 200                 205             
Met Glu Glu Glu Glu Ala Ala Lys Glu Glu Lys Glu Glu Ser Asp Asp
    210                 215                 220                 
Glu Ala Ala Val Glu Glu Glu Glu Glu Glu Lys Lys Pro Lys Thr Lys
225                 230                 235                 240 
Lys Val Glu Lys Thr Val Trp Asp Trp Glu Leu Met Asn Asp Ile Lys
                245                 250                 255     
Pro Ile Trp Gln Arg Pro Ser Lys Glu Val Glu Glu Asp Glu Tyr Lys
            260                 265                 270         
Ala Phe Tyr Lys Ser Phe Ser Lys Glu Ser Asp Asp Pro Met Ala Tyr
        275                 280                 285             
Ile His Phe Thr Ala Glu Gly Glu Val Thr Phe Lys Ser Ile Leu Phe
    290                 295                 300                 
Val Pro Thr Ser Ala Pro Arg Gly Leu Phe Asp Glu Tyr Gly Ser Lys
305                 310                 315                 320 
Lys Ser Asp Tyr Ile Lys Leu Tyr Val Arg Arg Val Phe Ile Thr Asp
                325                 330                 335     
Asp Phe His Asp Met Met Pro Lys Tyr Leu Asn Phe Val Lys Gly Val
            340                 345                 350         
Val Asp Ser Asp Asp Leu Pro Leu Asn Val Ser Arg Glu Thr Leu Gln
        355                 360                 365             
Gln His Lys Leu Leu Lys Val Ile Arg Lys Lys Leu Val Arg Lys Thr
    370                 375                 380                 
Leu Asp Met Ile Lys Lys Ile Ala Asp Asp Lys Tyr Asn Asp Thr Phe
385                 390                 395                 400 
Trp Lys Glu Phe Gly Thr Asn Ile Lys Leu Gly Val Ile Glu Asp His
                405                 410                 415     
Ser Asn Arg Thr Arg Leu Ala Lys Leu Leu Arg Phe Gln Ser Ser His
            420                 425                 430         
His Pro Thr Asp Ile Thr Ser Leu Asp Gln Tyr Val Glu Arg Met Lys
        435                 440                 445             
Glu Lys Gln Asp Lys Ile Tyr Phe Met Ala Gly Ser Ser Arg Lys Glu
    450                 455                 460                 
Ala Glu Ser Ser Pro Phe Val Glu Arg Leu Leu Lys Lys Gly Tyr Glu
465                 470                 475                 480 
Val Ile Tyr Leu Thr Glu Pro Val Asp Glu Tyr Cys Ile Gln Ala Leu
                485                 490                 495     
Pro Glu Phe Asp Gly Lys Arg Phe Gln Asn Val Ala Lys Glu Gly Val
            500                 505                 510         
Lys Phe Asp Glu Ser Glu Lys Thr Lys Glu Ser Arg Glu Ala Val Glu
        515                 520                 525             
Lys Glu Phe Glu Pro Leu Leu Asn Trp Met Lys Asp Lys Ala Leu Lys
    530                 535                 540                 
Asp Lys Ile Glu Lys Ala Val Val Ser Gln Arg Leu Thr Glu Ser Pro
545                 550                 555                 560 
Cys Ala Leu Val Ala Ser Gln Tyr Gly Trp Ser Gly Asn Met Glu Arg
                565                 570                 575     
Ile Met Lys Ala Gln Ala Tyr Gln Thr Gly Lys Asp Ile Ser Thr Asn
            580                 585                 590         
Tyr Tyr Ala Ser Gln Lys Lys Thr Phe Glu Ile Asn Pro Arg His Pro
        595                 600                 605             
Leu Ile Arg Asp Met Leu Arg Arg Ile Lys Glu Asp Glu Asp Asp Lys
    610                 615                 620                 
Thr Val Leu Asp Leu Ala Val Val Leu Phe Glu Thr Ala Thr Leu Arg
625                 630                 635                 640 
Ser Gly Tyr Leu Leu Pro Asp Thr Lys Ala Tyr Gly Asp Arg Ile Glu
                645                 650                 655     
Arg Met Leu Arg Leu Ser Leu Asn Ile Asp Pro Asp Ala Lys Val Glu
            660                 665                 670         
Glu Glu Pro Glu Glu Glu Pro Glu Glu Thr Ala Glu Asp Thr Thr Glu
        675                 680                 685             
Asp Thr Glu Gln Asp Glu Asp Glu Glu Met Asp Val Gly Thr Asp Glu
    690                 695                 700                 
Glu Glu Glu Thr Ala Lys Glu Ser Thr Ala Glu Lys Asp Glu Leu
705                 710                 715                 


<210> 2107
<211> 359
<212> PRT
<213> Homo sapiens

<400> 2107
Met Val Asp Ile Ile Phe His Tyr Pro Phe Leu Gly Ala Met Gly Asp
 1               5                  10                  15      
His Ser Lys Lys Lys Pro Gly Thr Ala Met Cys Val Gly Cys Gly Ser
            20                  25                  30          
Gln Ile His Asp Gln Phe Ile Leu Arg Val Ser Pro Asp Leu Glu Trp
        35                  40                  45              
His Ala Ala Cys Leu Lys Cys Ala Glu Cys Ser Gln Tyr Leu Asp Glu
    50                  55                  60                  
Thr Cys Thr Cys Phe Val Arg Asp Gly Lys Thr Tyr Cys Lys Arg Asp
65                  70                  75                  80  
Tyr Val Arg Leu Phe Gly Ile Lys Cys Ala Lys Cys Gln Val Gly Phe
                85                  90                  95      
Ser Ser Ser Asp Leu Val Met Arg Ala Arg Asp Ser Val Tyr His Ile
            100                 105                 110         
Glu Cys Phe Arg Cys Ser Val Cys Ser Arg Gln Leu Leu Pro Gly Asp
        115                 120                 125             
Glu Phe Ser Leu Arg Glu His Glu Leu Leu Cys Arg Ala Asp His Gly
    130                 135                 140                 
Leu Leu Leu Glu Arg Ala Ala Ala Gly Ser Pro Arg Ser Pro Gly Pro
145                 150                 155                 160 
Leu Pro Gly Ala Arg Gly Leu His Leu Pro Asp Ala Gly Ser Gly Arg
                165                 170                 175     
Gln Pro Ala Leu Arg Pro His Val His Lys Gln Thr Glu Lys Thr Thr
            180                 185                 190         
Arg Val Arg Thr Val Leu Asn Glu Lys Gln Leu His Thr Leu Arg Thr
        195                 200                 205             
Cys Tyr Ala Ala Asn Pro Arg Pro Asp Ala Leu Met Lys Glu Gln Leu
    210                 215                 220                 
Val Glu Met Thr Gly Leu Ser Pro Arg Val Ile Arg Val Trp Phe Gln
225                 230                 235                 240 
Asn Lys Arg Cys Lys Asp Lys Lys Lys Ser Ile Leu Met Lys Gln Leu
                245                 250                 255     
Gln Gln Gln Gln His Ser Asp Lys Thr Ser Leu Gln Gly Leu Thr Gly
            260                 265                 270         
Thr Pro Leu Val Ala Gly Ser Pro Ile Arg His Glu Asn Ala Val Gln
        275                 280                 285             
Gly Ser Ala Val Glu Val Gln Thr Tyr Gln Pro Pro Trp Lys Ala Leu
    290                 295                 300                 
Ser Glu Phe Ala Leu Gln Ser Asp Leu Asp Gln Pro Ala Phe Gln Gln
305                 310                 315                 320 
Leu Val Ser Phe Ser Glu Ser Gly Ser Leu Gly Asn Ser Ser Gly Ser
                325                 330                 335     
Asp Val Thr Ser Leu Ser Ser Gln Leu Pro Asp Thr Pro Asn Ser Met
            340                 345                 350         
Val Pro Ser Pro Val Glu Thr
        355                 


<210> 2108
<211> 180
<212> PRT
<213> Homo sapiens

<400> 2108
Met Ala Leu Arg Ser Arg Phe Trp Gly Leu Phe Ser Val Cys Arg Asn
 1               5                  10                  15      
Pro Gly Cys Arg Phe Ala Ala Leu Ser Thr Ser Ser Glu Pro Ala Ala
            20                  25                  30          
Lys Pro Glu Val Asp Pro Val Glu Asn Glu Ala Val Ala Pro Glu Phe
        35                  40                  45              
Thr Asn Arg Asn Pro Arg Asn Leu Glu Leu Leu Ser Val Ala Arg Lys
    50                  55                  60                  
Glu Arg Gly Trp Arg Thr Val Phe Pro Ser Arg Glu Phe Trp His Arg
65                  70                  75                  80  
Leu Arg Val Ile Arg Thr Gln His His Val Glu Ala Leu Val Glu His
                85                  90                  95      
Gln Asn Gly Lys Val Val Val Ser Ala Ser Thr Arg Glu Trp Ala Ile
            100                 105                 110         
Lys Lys His Leu Tyr Ser Thr Arg Asn Val Val Ala Cys Glu Ser Ile
        115                 120                 125             
Gly Arg Val Leu Ala Gln Arg Cys Leu Glu Ala Gly Ile Asn Phe Met
    130                 135                 140                 
Val Tyr Gln Pro Thr Pro Trp Glu Ala Ala Ser Asp Ser Met Lys Arg
145                 150                 155                 160 
Leu Gln Ser Ala Met Thr Glu Gly Gly Val Val Leu Arg Glu Pro Gln
                165                 170                 175     
Arg Ile Tyr Glu
            180 


<210> 2109
<211> 222
<212> PRT
<213> Homo sapiens

<400> 2109
Met Leu Ser Arg Ala Val Cys Gly Thr Ser Arg Gln Leu Ala Pro Val
 1               5                  10                  15      
Leu Gly Tyr Leu Gly Ser Arg Gln Lys His Ser Leu Pro Asp Leu Pro
            20                  25                  30          
Tyr Asp Tyr Gly Ala Leu Glu Pro His Ile Asn Ala Gln Ile Met Gln
        35                  40                  45              
Leu His His Ser Lys His His Ala Ala Tyr Val Asn Asn Leu Asn Val
    50                  55                  60                  
Thr Glu Glu Lys Tyr Gln Glu Ala Leu Ala Lys Gly Asp Val Thr Ala
65                  70                  75                  80  
Gln Ile Ala Leu Gln Pro Ala Leu Lys Phe Asn Gly Gly Gly His Ile
                85                  90                  95      
Asn His Ser Ile Phe Trp Thr Asn Leu Ser Pro Asn Gly Gly Gly Glu
            100                 105                 110         
Pro Lys Gly Glu Leu Leu Glu Ala Ile Lys Arg Asp Phe Gly Ser Phe
        115                 120                 125             
Asp Lys Phe Lys Glu Lys Leu Thr Ala Ala Ser Val Gly Val Gln Gly
    130                 135                 140                 
Ser Gly Trp Gly Trp Leu Gly Phe Asn Lys Glu Arg Gly His Leu Gln
145                 150                 155                 160 
Ile Ala Ala Cys Pro Asn Gln Asp Pro Leu Gln Gly Thr Thr Gly Leu
                165                 170                 175     
Ile Pro Leu Leu Gly Ile Asp Val Trp Glu His Ala Tyr Tyr Leu Gln
            180                 185                 190         
Tyr Lys Asn Val Arg Pro Asp Tyr Leu Lys Ala Ile Trp Asn Val Ile
        195                 200                 205             
Asn Trp Glu Asn Val Thr Glu Arg Tyr Met Ala Cys Lys Lys
    210                 215                 220         


<210> 2110
<211> 474
<212> PRT
<213> Homo sapiens

<400> 2110
Met Phe Leu Ser Ser Cys Thr Phe Glu Val Ser Gly Lys Pro Phe Thr
 1               5                  10                  15      
Cys Lys Glu Val Gly Lys Asp Phe Leu Val Arg Ser Arg Phe Leu Gln
            20                  25                  30          
Gln Gln Ala Ala His Thr Arg Lys Lys Ser Asn Arg Thr Lys Ser Ala
        35                  40                  45              
Val Ala Phe His Ser Val Lys Asn His Tyr Asn Trp Gly Glu Cys Val
    50                  55                  60                  
Lys Ala Phe Ser Tyr Lys His Val Arg Val Gln His Gln Gly Asp Leu
65                  70                  75                  80  
Ile Arg Glu Arg Ser Tyr Met Cys Ser Glu Cys Gly Lys Ser Phe Ser
                85                  90                  95      
Thr Ser Cys Ser Leu Ser Asp His Leu Arg Val His Thr Ser Glu Lys
            100                 105                 110         
Pro Tyr Thr Cys Gly Glu Cys Gly Lys Ser Tyr Arg Gln Ser Ser Ser
        115                 120                 125             
Leu Ile Thr His Arg Arg Ile His Thr Gly Val Arg Pro His Gln Cys
    130                 135                 140                 
Asp Glu Cys Gly Lys Leu Phe Asn Arg Lys Tyr Asp Leu Leu Ile His
145                 150                 155                 160 
Gln Arg Val His Thr Gly Glu Arg Pro Tyr Lys Cys Ser Glu Cys Gly
                165                 170                 175     
Lys Ser Phe Ser His Ser Ser Ser Leu Ile Thr His Gln Arg Ile His
            180                 185                 190         
Thr Gly Met Arg Pro Tyr Glu Cys Ser Glu Cys Gly Lys Ser Phe Ile
        195                 200                 205             
His Ser Ser Ser Leu Ile Thr His Gln Arg Val His Thr Gly Thr Arg
    210                 215                 220                 
Pro Tyr Met Cys Ser Glu Cys Gly Lys Ser Phe Ser Gln Ser Cys His
225                 230                 235                 240 
Leu Ile Lys His Arg Arg Leu His Ile Gly Glu Gly Pro Tyr Glu Cys
                245                 250                 255     
Ser Glu Cys Gly Lys Leu Phe Thr Tyr Arg Ser Arg Phe Phe Gln His
            260                 265                 270         
Gln Arg Val His Thr Gly Val Arg Ser His Glu Cys His Glu Cys Gly
        275                 280                 285             
Lys Leu Phe Ser Arg Lys Phe Asp Leu Ile Val His Glu Arg Val His
    290                 295                 300                 
Thr Gly Glu Arg Pro Tyr Glu Cys Ser Glu Cys Gly Lys Ser Phe Thr
305                 310                 315                 320 
Cys Lys Ser Tyr Leu Ile Ser His Trp Lys Val His Thr Gly Ala Arg
                325                 330                 335     
Pro Tyr Glu Cys Gly Glu Cys Gly Lys Ser Phe Thr His Ser Ser Thr
            340                 345                 350         
Leu Leu Gln His Gln Arg Val His Thr Gly Glu Arg Pro Tyr Glu Cys
        355                 360                 365             
Asn Glu Cys Gly Lys Phe Phe Ser Gln Ser Ser Ser Leu Ile Arg His
    370                 375                 380                 
Arg Arg Ser His Thr Gly Glu Arg Pro Tyr Glu Cys Ser Glu Cys Trp
385                 390                 395                 400 
Lys Ser Phe Ser Asn His Ser Ser Leu Val Lys His Arg Arg Val His
                405                 410                 415     
Thr Gly Glu Arg Pro Tyr Glu Cys Ser Glu Cys Gly Lys Ser Phe Ser
            420                 425                 430         
Gln Ser Ser Asn Leu Thr Asn His Gln Arg Ile His Ser Gly Glu Arg
        435                 440                 445             
Pro Tyr Glu Cys Ser Asp Cys Gly Lys Phe Phe Thr Phe Asn Ser Asn
    450                 455                 460                 
Leu Leu Lys His Gln Asn Val His Lys Gly
465                 470                 


<210> 2111
<211> 146
<212> PRT
<213> Homo sapiens

<400> 2111
Met Arg Leu Leu Gly Leu Leu Thr Leu Asn Met Asn Ile Ala Met Pro
 1               5                  10                  15      
Ser Trp Phe Asp Ile Ile Gly Leu Ser Pro Asp Ser Gln Glu Asp Glu
            20                  25                  30          
Ser Gly Ile Lys Gln Ala Ala Gln Asn Ile Lys Ala Leu Ile Asp Gln
        35                  40                  45              
Glu Val Lys Asn Gly Ile Pro Ser Asn Arg Ile Ile Leu Gly Gly Phe
    50                  55                  60                  
Ser Gln Gly Gly Ala Leu Ser Leu Tyr Thr Ala Leu Thr Thr His Gln
65                  70                  75                  80  
Lys Leu Ala Gly Val Thr Ala Leu Asn Cys Trp Leu Pro Leu Trp Ala
                85                  90                  95      
Ser Phe Pro Gln Gly Pro Ile Gly Gly Ala Asn Arg Asp Ile Ser Ile
            100                 105                 110         
Leu Gln Cys His Gly Asp Cys Asp Pro Leu Val Pro Leu Met Phe Gly
        115                 120                 125             
Ser Leu Thr Val Glu Lys Leu Lys Asn Ile Gly Glu Ser Ser Gln Cys
    130                 135                 140                 
Asp Leu
145     


<210> 2112
<211> 983
<212> PRT
<213> Homo sapiens

<400> 2112
Met Thr Glu His Lys Met Ser Val Glu Glu Val Cys Arg Lys Tyr Asn
 1               5                  10                  15      
Thr Asp Cys Val Gln Gly Leu Thr His Ser Lys Ala Gln Glu Ile Leu
            20                  25                  30          
Ala Arg Asp Gly Pro Asn Ala Leu Thr Pro Pro Pro Thr Thr Pro Glu
        35                  40                  45              
Trp Val Lys Phe Cys Arg Gln Leu Phe Gly Gly Phe Ser Ile Leu Leu
    50                  55                  60                  
Trp Ile Gly Ala Ile Leu Cys Phe Leu Ala Tyr Gly Ile Gln Ala Gly
65                  70                  75                  80  
Thr Glu Asp Asp Pro Ser Gly Asp Asn Leu Tyr Leu Gly Ile Val Leu
                85                  90                  95      
Ala Ala Val Val Ile Ile Thr Gly Cys Phe Ser Tyr Tyr Gln Glu Ala
            100                 105                 110         
Lys Ser Ser Lys Ile Met Glu Ser Phe Lys Asn Met Val Pro Gln Gln
        115                 120                 125             
Ala Leu Val Ile Arg Glu Gly Glu Lys Met Gln Val Asn Ala Glu Glu
    130                 135                 140                 
Val Val Val Gly Asp Leu Val Glu Ile Lys Gly Gly Asp Arg Val Pro
145                 150                 155                 160 
Ala Asp Leu Arg Ile Ile Ser Ala His Gly Cys Lys Val Asp Asn Ser
                165                 170                 175     
Ser Leu Thr Gly Glu Ser Glu Pro Gln Thr Arg Ser Pro Asp Cys Thr
            180                 185                 190         
His Asp Asn Pro Leu Glu Thr Arg Asn Ile Thr Phe Phe Ser Thr Asn
        195                 200                 205             
Cys Val Glu Gly Thr Ala Arg Gly Val Val Val Ala Thr Gly Asp Arg
    210                 215                 220                 
Thr Val Met Gly Arg Ile Ala Thr Leu Ala Ser Gly Leu Glu Val Gly
225                 230                 235                 240 
Lys Thr Pro Ile Ala Ile Glu Ile Glu His Phe Ile Gln Leu Ile Thr
                245                 250                 255     
Gly Val Ala Val Phe Leu Gly Val Ser Phe Phe Ile Leu Ser Leu Ile
            260                 265                 270         
Leu Gly Tyr Thr Trp Leu Glu Ala Val Ile Phe Leu Ile Gly Ile Ile
        275                 280                 285             
Val Ala Asn Val Pro Glu Gly Leu Leu Ala Thr Val Thr Val Cys Leu
    290                 295                 300                 
Thr Leu Thr Ala Lys Arg Met Ala Arg Lys Asn Cys Leu Val Lys Asn
305                 310                 315                 320 
Leu Glu Ala Val Glu Thr Leu Gly Ser Thr Ser Thr Ile Cys Ser Asp
                325                 330                 335     
Lys Thr Gly Thr Leu Thr Gln Asn Arg Met Thr Val Ala His Met Trp
            340                 345                 350         
Phe Asp Asn Gln Ile His Glu Ala Asp Thr Thr Glu Asp Gln Ser Gly
        355                 360                 365             
Thr Ser Phe Asp Lys Ser Ser His Thr Trp Val Ala Leu Ser His Ile
    370                 375                 380                 
Ala Gly Leu Cys Asn Arg Ala Val Phe Lys Gly Gly Gln Asp Asn Ile
385                 390                 395                 400 
Pro Val Leu Lys Arg Asp Val Ala Gly Asp Ala Ser Glu Ser Ala Leu
                405                 410                 415     
Leu Lys Cys Ile Glu Leu Ser Ser Gly Ser Val Lys Leu Met Arg Glu
            420                 425                 430         
Arg Asn Lys Lys Val Ala Glu Ile Pro Phe Asn Ser Thr Asn Lys Tyr
        435                 440                 445             
Gln Leu Ser Ile His Glu Thr Glu Asp Pro Asn Asp Asn Arg Tyr Leu
    450                 455                 460                 
Leu Val Met Lys Gly Ala Pro Glu Arg Ile Leu Asp Arg Cys Ser Thr
465                 470                 475                 480 
Ile Leu Leu Gln Gly Lys Glu Gln Pro Leu Asp Glu Glu Met Lys Glu
                485                 490                 495     
Ala Phe Gln Asn Ala Tyr Leu Glu Leu Gly Gly Leu Gly Glu Arg Val
            500                 505                 510         
Leu Gly Phe Cys His Tyr Tyr Leu Pro Glu Glu Gln Phe Pro Lys Gly
        515                 520                 525             
Phe Ala Phe Asp Cys Asp Asp Val Asn Phe Thr Thr Asp Asn Leu Cys
    530                 535                 540                 
Phe Val Gly Leu Met Ser Met Ile Asp Pro Pro Arg Ala Ala Val Pro
545                 550                 555                 560 
Asp Ala Val Gly Lys Cys Arg Ser Ala Gly Ile Lys Val Ile Met Val
                565                 570                 575     
Thr Gly Asp His Pro Ile Thr Ala Lys Ala Ile Ala Lys Gly Val Gly
            580                 585                 590         
Ile Ile Ser Glu Gly Asn Glu Thr Val Glu Asp Ile Ala Ala Arg Leu
        595                 600                 605             
Asn Ile Pro Val Ser Gln Val Asn Pro Arg Asp Ala Lys Ala Cys Val
    610                 615                 620                 
Ile His Gly Thr Asp Leu Lys Asp Phe Thr Ser Glu Gln Ile Asp Glu
625                 630                 635                 640 
Ile Leu Gln Asn His Thr Glu Ile Val Phe Ala Arg Thr Ser Pro Gln
                645                 650                 655     
Gln Lys Leu Ile Ile Val Glu Gly Cys Gln Arg Gln Gly Ala Ile Val
            660                 665                 670         
Ala Val Thr Gly Asp Gly Val Asn Asp Ser Pro Ala Leu Lys Lys Ala
        675                 680                 685             
Asp Ile Gly Val Ala Met Gly Ile Ala Gly Ser Asp Val Ser Lys Gln
    690                 695                 700                 
Ala Ala Asp Met Ile Leu Leu Asp Asp Asn Phe Ala Ser Ile Val Thr
705                 710                 715                 720 
Gly Val Glu Glu Gly Arg Leu Ile Phe Asp Asn Leu Lys Lys Ser Ile
                725                 730                 735     
Ala Tyr Thr Leu Thr Ser Asn Ile Pro Glu Ile Thr Pro Phe Leu Leu
            740                 745                 750         
Phe Ile Met Ala Asn Ile Pro Leu Pro Leu Gly Thr Ile Thr Ile Leu
        755                 760                 765             
Cys Ile Asp Leu Gly Thr Asp Met Val Pro Ala Ile Ser Leu Ala Tyr
    770                 775                 780                 
Glu Ala Ala Glu Ser Asp Ile Met Lys Arg Gln Pro Arg Asn Pro Arg
785                 790                 795                 800 
Thr Asp Lys Leu Val Asn Glu Arg Leu Ile Ser Met Ala Tyr Gly Gln
                805                 810                 815     
Ile Gly Met Ile Gln Ala Leu Gly Gly Phe Phe Ser Tyr Phe Val Ile
            820                 825                 830         
Leu Ala Glu Asn Gly Phe Leu Pro Gly Asn Leu Val Gly Ile Arg Leu
        835                 840                 845             
Asn Trp Asp Asp Arg Thr Val Asn Asp Leu Glu Asp Ser Tyr Gly Gln
    850                 855                 860                 
Gln Trp Thr Tyr Glu Gln Arg Lys Val Val Glu Phe Thr Cys His Thr
865                 870                 875                 880 
Ala Phe Phe Val Ser Ile Val Val Val Gln Trp Ala Asp Leu Ile Ile
                885                 890                 895     
Cys Lys Thr Arg Arg Asn Ser Val Phe Gln Gln Gly Met Lys Asn Lys
            900                 905                 910         
Ile Leu Ile Phe Gly Leu Phe Glu Glu Thr Ala Leu Ala Ala Phe Leu
        915                 920                 925             
Ser Tyr Cys Pro Gly Met Asp Val Ala Leu Arg Met Tyr Pro Leu Lys
    930                 935                 940                 
Pro Ser Trp Trp Phe Cys Ala Phe Pro Tyr Ser Phe Leu Ile Phe Val
945                 950                 955                 960 
Tyr Asp Glu Ile Arg Lys Leu Ile Leu Arg Arg Asn Pro Gly Gly Trp
                965                 970                 975     
Val Glu Lys Glu Thr Tyr Tyr
            980             


<210> 2113
<211> 1013
<212> PRT
<213> Homo sapiens

<400> 2113
Met Gly Asp Lys Lys Asp Asp Lys Asp Ser Pro Lys Lys Asn Lys Gly
 1               5                  10                  15      
Lys Glu Arg Arg Asp Leu Asp Asp Leu Lys Lys Glu Val Ala Met Thr
            20                  25                  30          
Glu His Lys Met Ser Val Glu Glu Val Cys Arg Lys Tyr Asn Thr Asp
        35                  40                  45              
Cys Val Gln Gly Leu Thr His Ser Lys Ala Gln Glu Ile Leu Ala Arg
    50                  55                  60                  
Asp Gly Pro Asn Ala Leu Thr Pro Pro Pro Thr Thr Pro Glu Trp Val
65                  70                  75                  80  
Lys Phe Cys Arg Gln Leu Phe Gly Gly Phe Ser Ile Leu Leu Trp Ile
                85                  90                  95      
Gly Ala Ile Leu Cys Phe Leu Ala Tyr Gly Ile Gln Ala Gly Thr Glu
            100                 105                 110         
Asp Asp Pro Ser Gly Asp Asn Leu Tyr Leu Gly Ile Val Leu Ala Ala
        115                 120                 125             
Val Val Ile Ile Thr Gly Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser
    130                 135                 140                 
Ser Lys Ile Met Glu Ser Phe Lys Asn Met Val Pro Gln Gln Ala Leu
145                 150                 155                 160 
Val Ile Arg Glu Gly Glu Lys Met Gln Val Asn Ala Glu Glu Val Val
                165                 170                 175     
Val Gly Asp Leu Val Glu Ile Lys Gly Gly Asp Arg Val Pro Ala Asp
            180                 185                 190         
Leu Arg Ile Ile Ser Ala His Gly Cys Lys Val Asp Asn Ser Ser Leu
        195                 200                 205             
Thr Gly Glu Ser Glu Pro Gln Thr Arg Ser Pro Asp Cys Thr His Asp
    210                 215                 220                 
Asn Pro Leu Glu Thr Arg Asn Ile Thr Phe Phe Ser Thr Asn Cys Val
225                 230                 235                 240 
Glu Gly Thr Ala Arg Gly Val Val Val Ala Thr Gly Asp Arg Thr Val
                245                 250                 255     
Met Gly Arg Ile Ala Thr Leu Ala Ser Gly Leu Glu Val Gly Lys Thr
            260                 265                 270         
Pro Ile Ala Ile Glu Ile Glu His Phe Ile Gln Leu Ile Thr Gly Val
        275                 280                 285             
Ala Val Phe Leu Gly Val Ser Phe Phe Ile Leu Ser Leu Ile Leu Gly
    290                 295                 300                 
Tyr Thr Trp Leu Glu Ala Val Ile Phe Leu Ile Gly Ile Ile Val Ala
305                 310                 315                 320 
Asn Val Pro Glu Gly Leu Leu Ala Thr Val Thr Val Cys Leu Thr Leu
                325                 330                 335     
Thr Ala Lys Arg Met Ala Arg Lys Asn Cys Leu Val Lys Asn Leu Glu
            340                 345                 350         
Ala Val Glu Thr Leu Gly Ser Thr Ser Thr Ile Cys Ser Asp Lys Thr
        355                 360                 365             
Gly Thr Leu Thr Gln Asn Arg Met Thr Val Ala His Met Trp Phe Asp
    370                 375                 380                 
Asn Gln Ile His Glu Ala Asp Thr Thr Glu Asp Gln Ser Gly Thr Ser
385                 390                 395                 400 
Phe Asp Lys Ser Ser His Thr Trp Val Ala Leu Ser His Ile Ala Gly
                405                 410                 415     
Leu Cys Asn Arg Ala Val Phe Lys Gly Gly Gln Asp Asn Ile Pro Val
            420                 425                 430         
Leu Lys Arg Asp Val Ala Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys
        435                 440                 445             
Cys Ile Glu Leu Ser Ser Gly Ser Val Lys Leu Met Arg Glu Arg Asn
    450                 455                 460                 
Lys Lys Val Ala Glu Ile Pro Phe Asn Ser Thr Asn Lys Tyr Gln Leu
465                 470                 475                 480 
Ser Ile His Glu Thr Glu Asp Pro Asn Asp Asn Arg Tyr Leu Leu Val
                485                 490                 495     
Met Lys Gly Ala Pro Glu Arg Ile Leu Asp Arg Cys Ser Thr Ile Leu
            500                 505                 510         
Leu Gln Gly Lys Glu Gln Pro Leu Asp Glu Glu Met Lys Glu Ala Phe
        515                 520                 525             
Gln Asn Ala Tyr Leu Glu Leu Gly Gly Leu Gly Glu Arg Val Leu Gly
    530                 535                 540                 
Phe Cys His Tyr Tyr Leu Pro Glu Glu Gln Phe Pro Lys Gly Phe Ala
545                 550                 555                 560 
Phe Asp Cys Asp Asp Val Asn Phe Thr Thr Asp Asn Leu Cys Phe Val
                565                 570                 575     
Gly Leu Met Ser Met Ile Asp Pro Pro Arg Ala Ala Val Pro Asp Ala
            580                 585                 590         
Val Gly Lys Cys Arg Ser Ala Gly Ile Lys Val Ile Met Val Thr Gly
        595                 600                 605             
Asp His Pro Ile Thr Ala Lys Ala Ile Ala Lys Gly Val Gly Ile Ile
    610                 615                 620                 
Ser Glu Gly Asn Glu Thr Val Glu Asp Ile Ala Ala Arg Leu Asn Ile
625                 630                 635                 640 
Pro Val Ser Gln Val Asn Pro Arg Asp Ala Lys Ala Cys Val Ile His
                645                 650                 655     
Gly Thr Asp Leu Lys Asp Phe Thr Ser Glu Gln Ile Asp Glu Ile Leu
            660                 665                 670         
Gln Asn His Thr Glu Ile Val Phe Ala Arg Thr Ser Pro Gln Gln Lys
        675                 680                 685             
Leu Ile Ile Val Glu Gly Cys Gln Arg Gln Gly Ala Ile Val Ala Val
    690                 695                 700                 
Thr Gly Asp Gly Val Asn Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile
705                 710                 715                 720 
Gly Val Ala Met Gly Ile Ala Gly Ser Asp Val Ser Lys Gln Ala Ala
                725                 730                 735     
Asp Met Ile Leu Leu Asp Asp Asn Phe Ala Ser Ile Val Thr Gly Val
            740                 745                 750         
Glu Glu Gly Arg Leu Ile Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr
        755                 760                 765             
Thr Leu Thr Ser Asn Ile Pro Glu Ile Thr Pro Phe Leu Leu Phe Ile
    770                 775                 780                 
Met Ala Asn Ile Pro Leu Pro Leu Gly Thr Ile Thr Ile Leu Cys Ile
785                 790                 795                 800 
Asp Leu Gly Thr Asp Met Val Pro Ala Ile Ser Leu Ala Tyr Glu Ala
                805                 810                 815     
Ala Glu Ser Asp Ile Met Lys Arg Gln Pro Arg Asn Pro Arg Thr Asp
            820                 825                 830         
Lys Leu Val Asn Glu Arg Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly
        835                 840                 845             
Met Ile Gln Ala Leu Gly Gly Phe Phe Ser Tyr Phe Val Ile Leu Ala
    850                 855                 860                 
Glu Asn Gly Phe Leu Pro Gly Asn Leu Val Gly Ile Arg Leu Asn Trp
865                 870                 875                 880 
Asp Asp Arg Thr Val Asn Asp Leu Glu Asp Ser Tyr Gly Gln Gln Trp
                885                 890                 895     
Thr Tyr Glu Gln Arg Lys Val Val Glu Phe Thr Cys His Thr Ala Phe
            900                 905                 910         
Phe Val Ser Ile Val Val Val Gln Trp Ala Asp Leu Ile Ile Cys Lys
        915                 920                 925             
Thr Arg Arg Asn Ser Val Phe Gln Gln Gly Met Lys Asn Lys Ile Leu
    930                 935                 940                 
Ile Phe Gly Leu Phe Glu Glu Thr Ala Leu Ala Ala Phe Leu Ser Tyr
945                 950                 955                 960 
Cys Pro Gly Met Asp Val Ala Leu Arg Met Tyr Pro Leu Lys Pro Ser
                965                 970                 975     
Trp Trp Phe Cys Ala Phe Pro Tyr Ser Phe Leu Ile Phe Val Tyr Asp
            980                 985                 990         
Glu Ile Arg Lys Leu Ile Leu Arg Arg Asn Pro Gly Gly Trp Val Glu
        995                 1000                1005            
Lys Glu Thr Tyr Tyr
    1010            


<210> 2114
<211> 1280
<212> PRT
<213> Homo sapiens

<400> 2114
Met Ala Arg Ala Lys Thr Val Met Asn Ser Lys Thr His Pro Pro Lys
 1               5                  10                  15      
Cys Ile Gln Cys Gly Gln Tyr Leu Asp Asp Pro Asp Leu Lys Tyr Gly
            20                  25                  30          
Gln His Pro Pro Asp Ala Val Asp Glu Pro Gln Met Leu Thr Asn Glu
        35                  40                  45              
Lys Leu Ser Ile Phe Asp Ala Asn Glu Ser Gly Phe Glu Ser Tyr Glu
    50                  55                  60                  
Ala Leu Pro Gln His Lys Leu Thr Cys Phe Ser Val Tyr Cys Lys His
65                  70                  75                  80  
Gly His Leu Cys Pro Ile Asp Thr Gly Leu Ile Glu Lys Asn Ile Glu
                85                  90                  95      
Leu Phe Phe Ser Gly Ser Ala Lys Pro Ile Tyr Asp Asp Asp Pro Ser
            100                 105                 110         
Leu Glu Gly Gly Val Asn Gly Lys Asn Leu Gly Pro Ile Asn Glu Trp
        115                 120                 125             
Trp Ile Thr Gly Phe Asp Gly Gly Glu Lys Ala Leu Ile Gly Phe Ser
    130                 135                 140                 
Thr Ser Phe Ala Glu Tyr Ile Leu Met Asp Pro Ser Pro Glu Tyr Ala
145                 150                 155                 160 
Pro Ile Phe Gly Leu Met Gln Glu Lys Ile Tyr Ile Ser Lys Ile Val
                165                 170                 175     
Val Glu Phe Leu Gln Ser Asn Ser Asp Ser Thr Tyr Glu Asp Leu Ile
            180                 185                 190         
Asn Lys Ile Glu Thr Thr Val Pro Pro Ser Gly Leu Asn Leu Asn Arg
        195                 200                 205             
Phe Thr Glu Asp Ser Leu Leu Arg His Ala Gln Phe Val Val Glu Gln
    210                 215                 220                 
Val Glu Ser Tyr Asp Glu Ala Gly Asp Ser Asp Glu Gln Pro Ile Phe
225                 230                 235                 240 
Leu Thr Pro Cys Met Arg Asp Leu Ile Lys Leu Ala Gly Val Thr Leu
                245                 250                 255     
Gly Gln Arg Arg Ala Gln Ala Arg Arg Gln Thr Ile Arg His Ser Thr
            260                 265                 270         
Arg Glu Lys Asp Arg Gly Pro Thr Lys Ala Thr Thr Thr Lys Leu Val
        275                 280                 285             
Tyr Gln Ile Phe Asp Thr Phe Phe Ala Glu Gln Ile Glu Lys Asp Asp
    290                 295                 300                 
Arg Glu Asp Lys Glu Asn Ala Phe Lys Arg Arg Arg Cys Gly Val Cys
305                 310                 315                 320 
Glu Val Cys Gln Gln Pro Glu Cys Gly Lys Cys Lys Ala Cys Lys Asp
                325                 330                 335     
Met Val Lys Phe Gly Gly Ser Gly Arg Ser Lys Gln Ala Cys Gln Glu
            340                 345                 350         
Arg Arg Cys Pro Asn Met Ala Met Lys Glu Ala Asp Asp Asp Glu Glu
        355                 360                 365             
Val Asp Asp Asn Ile Pro Glu Met Pro Ser Pro Lys Lys Met His Gln
    370                 375                 380                 
Gly Lys Lys Lys Lys Gln Asn Lys Asn Arg Ile Ser Trp Val Gly Glu
385                 390                 395                 400 
Ala Val Lys Thr Asp Gly Lys Lys Ser Tyr Tyr Lys Lys Val Cys Ile
                405                 410                 415     
Asp Ala Glu Thr Leu Glu Val Gly Asp Cys Val Ser Val Ile Pro Asp
            420                 425                 430         
Asp Ser Ser Lys Pro Leu Tyr Leu Ala Arg Val Thr Ala Leu Trp Glu
        435                 440                 445             
Asp Ser Ser Asn Gly Gln Met Phe His Ala His Trp Phe Cys Ala Gly
    450                 455                 460                 
Thr Asp Thr Val Leu Gly Ala Thr Ser Asp Pro Leu Glu Leu Phe Leu
465                 470                 475                 480 
Val Asp Glu Cys Glu Asp Met Gln Leu Ser Tyr Ile His Ser Lys Val
                485                 490                 495     
Lys Val Ile Tyr Lys Ala Pro Ser Glu Asn Trp Ala Met Glu Gly Gly
            500                 505                 510         
Met Asp Pro Glu Ser Leu Leu Glu Gly Asp Asp Gly Lys Thr Tyr Phe
        515                 520                 525             
Tyr Gln Leu Trp Tyr Asp Gln Asp Tyr Ala Arg Phe Glu Ser Pro Pro
    530                 535                 540                 
Lys Thr Gln Pro Thr Glu Asp Asn Lys Phe Lys Phe Cys Val Ser Cys
545                 550                 555                 560 
Ala Arg Leu Ala Glu Met Arg Gln Lys Glu Ile Pro Arg Val Leu Glu
                565                 570                 575     
Gln Leu Glu Asp Leu Asp Ser Arg Val Leu Tyr Tyr Ser Ala Thr Lys
            580                 585                 590         
Asn Gly Ile Leu Tyr Arg Val Gly Asp Gly Val Tyr Leu Pro Pro Glu
        595                 600                 605             
Ala Phe Thr Phe Asn Ile Lys Leu Ser Ser Pro Val Lys Arg Pro Arg
    610                 615                 620                 
Lys Glu Pro Val Asp Glu Asp Leu Tyr Pro Glu His Tyr Arg Lys Tyr
625                 630                 635                 640 
Ser Asp Tyr Ile Lys Gly Ser Asn Leu Asp Ala Pro Glu Pro Tyr Arg
                645                 650                 655     
Ile Gly Arg Ile Lys Glu Ile Phe Cys Pro Lys Lys Ser Asn Gly Arg
            660                 665                 670         
Pro Asn Glu Thr Asp Ile Lys Ile Arg Val Asn Lys Phe Tyr Arg Pro
        675                 680                 685             
Glu Asn Thr His Lys Ser Thr Pro Ala Ser Tyr His Ala Asp Ile Asn
    690                 695                 700                 
Leu Leu Tyr Trp Ser Asp Glu Glu Ala Val Val Asp Phe Lys Ala Val
705                 710                 715                 720 
Gln Gly Arg Cys Thr Val Glu Tyr Gly Glu Asp Leu Pro Glu Cys Val
                725                 730                 735     
Gln Val Tyr Ser Met Gly Gly Pro Asn Arg Phe Tyr Phe Leu Glu Ala
            740                 745                 750         
Tyr Asn Ala Lys Ser Lys Ser Phe Glu Asp Pro Pro Asn His Ala Arg
        755                 760                 765             
Ser Pro Gly Asn Lys Gly Lys Gly Lys Gly Lys Gly Lys Gly Lys Pro
    770                 775                 780                 
Lys Ser Gln Ala Cys Glu Pro Ser Glu Pro Glu Ile Glu Ile Lys Leu
785                 790                 795                 800 
Pro Lys Leu Arg Thr Leu Asp Val Phe Ser Gly Cys Gly Gly Leu Ser
                805                 810                 815     
Glu Gly Phe His Gln Ala Gly Ile Ser Asp Thr Leu Trp Ala Ile Glu
            820                 825                 830         
Met Trp Asp Pro Ala Ala Gln Ala Phe Arg Leu Asn Asn Pro Gly Ser
        835                 840                 845             
Thr Val Phe Thr Glu Asp Cys Asn Ile Leu Leu Lys Leu Val Met Ala
    850                 855                 860                 
Gly Glu Thr Thr Asn Ser Arg Gly Gln Arg Leu Pro Gln Lys Gly Asp
865                 870                 875                 880 
Val Glu Met Leu Cys Gly Gly Pro Pro Cys Gln Gly Phe Ser Gly Met
                885                 890                 895     
Asn Arg Phe Asn Ser Arg Thr Tyr Ser Lys Phe Lys Asn Ser Leu Val
            900                 905                 910         
Val Ser Phe Leu Ser Tyr Cys Asp Tyr Tyr Arg Pro Arg Phe Phe Leu
        915                 920                 925             
Leu Glu Asn Val Arg Asn Phe Val Ser Phe Lys Arg Ser Met Val Leu
    930                 935                 940                 
Lys Leu Thr Leu Arg Cys Leu Val Arg Met Gly Tyr Gln Cys Thr Phe
945                 950                 955                 960 
Gly Val Leu Gln Ala Gly Gln Tyr Gly Val Ala Gln Thr Arg Arg Arg
                965                 970                 975     
Ala Ile Ile Leu Ala Ala Ala Pro Gly Glu Lys Leu Pro Leu Phe Pro
            980                 985                 990         
Glu Pro Leu His Val Phe Ala Pro Arg Ala Cys Gln Leu Ser Val Val
        995                 1000                1005            
Val Asp Asp Lys Lys Phe Val Ser Asn Ile Thr Arg Leu Ser Ser Gly
    1010                1015                1020                
Pro Phe Arg Thr Ile Thr Val Arg Asp Thr Met Ser Asp Leu Pro Glu
1025                1030                1035                1040
Val Arg Asn Gly Ala Ser Ala Leu Glu Ile Ser Tyr Asn Gly Glu Pro
                1045                1050                1055    
Gln Ser Trp Phe Gln Arg Gln Leu Arg Gly Ala Gln Tyr Gln Pro Ile
            1060                1065                1070        
Leu Arg Asp His Ile Cys Lys Asp Met Ser Ala Leu Val Ala Ala Arg
        1075                1080                1085            
Met Arg His Ile Pro Leu Ala Pro Gly Ser Asp Trp Arg Asp Leu Pro
    1090                1095                1100                
Asn Ile Glu Val Arg Leu Ser Asp Gly Thr Met Ala Arg Lys Leu Arg
1105                1110                1115                1120
Tyr Thr His His Asp Arg Lys Asn Gly Arg Ser Ser Ser Gly Ala Leu
                1125                1130                1135    
Arg Gly Val Cys Ser Cys Val Glu Ala Gly Lys Ala Cys Asp Pro Ala
            1140                1145                1150        
Ala Arg Gln Phe Asn Thr Leu Ile Pro Trp Cys Leu Pro His Thr Gly
        1155                1160                1165            
Asn Arg His Asn His Trp Ala Gly Leu Tyr Gly Arg Leu Glu Trp Asp
    1170                1175                1180                
Gly Phe Phe Ser Thr Thr Val Thr Asn Pro Glu Pro Met Gly Lys Gln
1185                1190                1195                1200
Gly Arg Val Leu His Pro Glu Gln His Arg Val Val Ser Val Arg Glu
                1205                1210                1215    
Cys Ala Arg Ser Gln Gly Phe Pro Asp Thr Tyr Arg Leu Phe Gly Asn
            1220                1225                1230        
Ile Leu Asp Lys His Arg Gln Val Gly Asn Ala Val Pro Pro Pro Leu
        1235                1240                1245            
Ala Lys Ala Ile Gly Leu Glu Ile Lys Leu Cys Met Leu Ala Lys Ala
    1250                1255                1260                
Arg Glu Ser Ala Ser Ala Lys Ile Lys Glu Glu Glu Ala Ala Lys Asp
1265                1270                1275                1280


<210> 2115
<211> 311
<212> PRT
<213> Homo sapiens

<400> 2115
Met Leu Gln Phe Val Arg Ala Gly Ala Arg Ala Trp Leu Arg Pro Thr
 1               5                  10                  15      
Gly Ser Gln Gly Leu Ser Ser Leu Ala Glu Glu Ala Ala Arg Ala Thr
            20                  25                  30          
Glu Asn Pro Glu Gln Val Ala Ser Glu Gly Leu Pro Glu Pro Val Leu
        35                  40                  45              
Arg Lys Val Glu Leu Pro Val Pro Thr His Arg Arg Pro Val Gln Ala
    50                  55                  60                  
Trp Val Glu Ser Leu Arg Gly Phe Glu Gln Glu Arg Val Gly Leu Ala
65                  70                  75                  80  
Asp Leu His Pro Asp Val Phe Ala Thr Ala Pro Arg Leu Asp Ile Leu
                85                  90                  95      
His Gln Val Ala Met Trp Gln Lys Asn Phe Lys Arg Ile Ser Tyr Ala
            100                 105                 110         
Lys Thr Lys Thr Arg Ala Glu Val Arg Gly Gly Gly Arg Lys Pro Trp
        115                 120                 125             
Pro Gln Lys Gly Thr Gly Arg Ala Arg His Gly Ser Ile Arg Ser Pro
    130                 135                 140                 
Leu Trp Arg Gly Gly Gly Val Ala His Gly Pro Arg Gly Pro Thr Ser
145                 150                 155                 160 
Tyr Tyr Tyr Met Leu Pro Met Lys Val Arg Ala Leu Gly Leu Lys Val
                165                 170                 175     
Ala Leu Thr Val Lys Leu Ala Gln Asp Asp Leu His Ile Met Asp Ser
            180                 185                 190         
Leu Glu Leu Pro Thr Gly Asp Pro Gln Tyr Leu Thr Glu Leu Ala His
        195                 200                 205             
Tyr Arg Arg Trp Gly Asp Ser Val Leu Leu Val Asp Leu Thr His Glu
    210                 215                 220                 
Glu Met Pro Gln Ser Ile Val Glu Ala Thr Ser Arg Leu Lys Thr Phe
225                 230                 235                 240 
Asn Leu Ile Pro Ala Val Gly Leu Asn Val His Ser Met Leu Lys His
                245                 250                 255     
Gln Thr Leu Val Leu Thr Leu Pro Thr Val Ala Phe Leu Glu Asp Lys
            260                 265                 270         
Leu Leu Trp Gln Asp Ser Arg Tyr Arg Pro Leu Tyr Pro Phe Ser Leu
        275                 280                 285             
Pro Tyr Ser Asp Phe Pro Arg Pro Leu Pro His Ala Thr Gln Gly Pro
    290                 295                 300                 
Ala Ala Thr Pro Tyr His Cys
305                 310     


<210> 2116
<211> 252
<212> PRT
<213> Homo sapiens

<400> 2116
Met Thr Pro Leu Cys Pro Arg Pro Ala Leu Cys Tyr His Phe Leu Thr
 1               5                  10                  15      
Ser Leu Leu Arg Ser Ala Met Gln Asn Ala Arg Gly Ala Arg Gln Arg
            20                  25                  30          
Ala Glu Ala Ala Val Leu Ser Gly Pro Gly Pro Pro Leu Gly Arg Ala
        35                  40                  45              
Ala Gln His Gly Ile Pro Arg Pro Leu Ser Ser Ala Gly Arg Leu Ser
    50                  55                  60                  
Gln Gly Cys Arg Gly Ala Ser Thr Val Gly Ala Ala Gly Trp Lys Gly
65                  70                  75                  80  
Glu Leu Pro Lys Ala Gly Gly Ser Pro Ala Pro Gly Pro Glu Thr Pro
                85                  90                  95      
Ala Ile Ser Pro Ser Lys Arg Ala Arg Pro Ala Glu Val Gly Gly Met
            100                 105                 110         
Gln Leu Arg Phe Ala Arg Leu Ser Glu His Ala Thr Ala Pro Thr Arg
        115                 120                 125             
Gly Ser Ala Arg Ala Ala Gly Tyr Asp Leu Tyr Ser Ala Tyr Asp Tyr
    130                 135                 140                 
Thr Ile Pro Pro Met Glu Lys Ala Val Val Lys Thr Asp Ile Gln Ile
145                 150                 155                 160 
Ala Leu Pro Ser Gly Cys Tyr Gly Arg Val Ala Pro Arg Ser Gly Leu
                165                 170                 175     
Ala Ala Lys His Phe Ile Asp Val Gly Ala Gly Val Ile Asp Glu Asp
            180                 185                 190         
Tyr Arg Gly Asn Val Gly Val Val Leu Phe Asn Phe Gly Lys Glu Lys
        195                 200                 205             
Phe Glu Val Lys Lys Gly Asp Arg Ile Ala Gln Leu Ile Cys Glu Arg
    210                 215                 220                 
Ile Phe Tyr Pro Glu Ile Glu Glu Val Gln Ala Leu Asp Asp Thr Glu
225                 230                 235                 240 
Arg Gly Ser Gly Gly Phe Gly Ser Thr Gly Lys Asn
                245                 250         


<210> 2117
<211> 1275
<212> PRT
<213> Homo sapiens

<400> 2117
Met Ser Leu Asp Phe Gly Ser Val Ala Leu Pro Val Gln Asn Glu Asp
 1               5                  10                  15      
Glu Glu Tyr Asp Glu Glu Asp Tyr Glu Arg Glu Lys Glu Leu Gln Gln
            20                  25                  30          
Leu Leu Thr Asp Leu Pro His Asp Met Leu Asp Asp Asp Leu Ser Ser
        35                  40                  45              
Pro Glu Leu Gln Tyr Ser Asp Cys Ser Glu Asp Gly Thr Asp Gly Gln
    50                  55                  60                  
Pro His His Pro Glu Gln Leu Glu Met Ser Trp Asn Glu Gln Met Leu
65                  70                  75                  80  
Pro Lys Ser Gln Ser Val Asn Gly Pro Ser Cys Gln Gly Leu Glu Pro
                85                  90                  95      
Tyr Asn Lys Val Thr Tyr Lys Pro Tyr Gln Ser Ser Ala Gln Asn Asn
            100                 105                 110         
Gly Ser Pro Ala Gln Glu Ile Thr Gly Ser Asp Thr Phe Glu Gly Leu
        115                 120                 125             
Gln Gln Gln Phe Leu Gly Ala Asn Glu Asn Ser Ala Glu Asn Met Gln
    130                 135                 140                 
Ile Ile Gln Leu Gln Val Leu Asn Lys Ala Lys Glu Arg Gln Leu Glu
145                 150                 155                 160 
Asn Leu Ile Glu Lys Leu Asn Glu Ser Glu Arg Gln Ile Arg Tyr Leu
                165                 170                 175     
Asn His Gln Leu Val Ile Ile Lys Asp Glu Lys Asp Gly Leu Thr Leu
            180                 185                 190         
Ser Leu Arg Glu Ser Gln Lys Leu Phe Gln Asn Gly Lys Glu Arg Glu
        195                 200                 205             
Ile Gln Leu Glu Ala Gln Ile Lys Ala Leu Glu Thr Gln Ile Gln Ala
    210                 215                 220                 
Leu Lys Val Asn Glu Glu Gln Met Ile Lys Lys Ser Arg Thr Thr Glu
225                 230                 235                 240 
Met Ala Leu Glu Ser Leu Lys Gln Gln Leu Val Asp Leu His His Ser
                245                 250                 255     
Glu Ser Leu Gln Arg Ala Arg Glu Gln His Glu Ser Ile Val Met Gly
            260                 265                 270         
Leu Thr Lys Lys Tyr Glu Glu Gln Val Leu Ser Leu Gln Lys Asn Leu
        275                 280                 285             
Asp Ala Thr Val Thr Ala Leu Lys Glu Gln Glu Asp Ile Cys Ser Arg
    290                 295                 300                 
Leu Lys Asp His Val Lys Gln Leu Glu Arg Asn Gln Glu Ala Ile Lys
305                 310                 315                 320 
Leu Glu Lys Thr Glu Ile Ile Asn Lys Leu Thr Arg Ser Leu Glu Glu
                325                 330                 335     
Ser Gln Lys Gln Cys Ala His Leu Leu Gln Ser Gly Ser Val Gln Glu
            340                 345                 350         
Val Ala Gln Leu Gln Phe Gln Leu Gln Gln Ala Gln Lys Ala His Ala
        355                 360                 365             
Met Ser Ala Asn Met Asn Lys Ala Leu Gln Glu Glu Leu Thr Glu Leu
    370                 375                 380                 
Lys Asp Glu Ile Ser Leu Tyr Glu Ser Ala Ala Lys Leu Gly Ile His
385                 390                 395                 400 
Pro Ser Asp Ser Glu Gly Glu Leu Asn Ile Glu Leu Thr Glu Ser Tyr
                405                 410                 415     
Val Asp Leu Gly Ile Lys Lys Val Asn Trp Lys Lys Ser Lys Val Thr
            420                 425                 430         
Ser Ile Val Gln Glu Glu Asp Pro Asn Glu Glu Leu Ser Lys Asp Glu
        435                 440                 445             
Phe Ile Leu Lys Leu Lys Ala Glu Val Gln Arg Leu Leu Gly Ser Asn
    450                 455                 460                 
Ser Met Lys Arg His Leu Val Ser Gln Leu Gln Asn Asp Leu Lys Asp
465                 470                 475                 480 
Cys His Lys Lys Ile Glu Asp Leu His Gln Val Lys Lys Asp Glu Lys
                485                 490                 495     
Ser Ile Glu Val Glu Thr Lys Thr Asp Thr Ser Glu Lys Pro Lys Asn
            500                 505                 510         
Gln Leu Trp Pro Glu Ser Ser Thr Ser Asp Val Val Arg Asp Asp Ile
        515                 520                 525             
Leu Leu Leu Lys Asn Glu Ile Gln Val Leu Gln Gln Gln Asn Gln Glu
    530                 535                 540                 
Leu Lys Glu Thr Glu Gly Lys Leu Arg Asn Thr Asn Gln Asp Leu Cys
545                 550                 555                 560 
Asn Gln Met Arg Gln Met Val Gln Asp Phe Asp His Asp Lys Gln Glu
                565                 570                 575     
Ala Val Asp Arg Cys Glu Arg Thr Tyr Gln Gln His His Glu Ala Met
            580                 585                 590         
Lys Thr Gln Ile Arg Glu Ser Leu Leu Ala Lys His Ala Leu Glu Lys
        595                 600                 605             
Gln Gln Leu Phe Glu Ala Tyr Glu Arg Thr His Leu Gln Leu Arg Ser
    610                 615                 620                 
Glu Leu Asp Lys Leu Asn Lys Glu Val Thr Ala Val Gln Glu Cys Tyr
625                 630                 635                 640 
Leu Glu Val Cys Arg Glu Lys Asp Asn Leu Glu Leu Thr Leu Arg Lys
                645                 650                 655     
Thr Thr Glu Lys Glu Gln Gln Thr Gln Glu Lys Ile Lys Glu Lys Leu
            660                 665                 670         
Ile Gln Gln Leu Glu Lys Glu Trp Gln Ser Lys Leu Asp Gln Thr Ile
        675                 680                 685             
Lys Ala Met Lys Lys Lys Thr Leu Asp Cys Gly Ser Gln Thr Asp Gln
    690                 695                 700                 
Val Thr Thr Ser Asp Val Ile Ser Lys Lys Glu Met Ala Ile Met Ile
705                 710                 715                 720 
Glu Glu Gln Lys Cys Thr Ile Gln Gln Asn Leu Glu Gln Glu Lys Asp
                725                 730                 735     
Ile Ala Ile Lys Gly Ala Met Lys Lys Leu Glu Ile Glu Leu Glu Leu
            740                 745                 750         
Lys His Cys Glu Asn Ile Thr Lys Gln Val Glu Ile Ala Val Gln Asn
        755                 760                 765             
Ala His Gln Arg Trp Leu Gly Glu Leu Pro Glu Leu Ala Glu Tyr Gln
    770                 775                 780                 
Ala Leu Val Lys Ala Glu Gln Lys Lys Trp Glu Glu Gln His Glu Val
785                 790                 795                 800 
Ser Val Asn Lys Arg Ile Ser Phe Ala Val Ser Glu Ala Lys Glu Lys
                805                 810                 815     
Trp Lys Ser Glu Leu Glu Asn Met Arg Lys Asn Ile Leu Pro Gly Lys
            820                 825                 830         
Glu Leu Glu Glu Lys Ile His Ser Leu Gln Lys Glu Leu Glu Leu Lys
        835                 840                 845             
Asn Glu Glu Val Pro Val Val Ile Arg Ala Glu Leu Ala Lys Ala Arg
    850                 855                 860                 
Ser Glu Trp Asn Lys Glu Lys Gln Glu Glu Ile His Arg Ile Gln Glu
865                 870                 875                 880 
Gln Asn Glu Gln Asp Tyr Arg Gln Phe Leu Asp Asp His Arg Asn Lys
                885                 890                 895     
Ile Asn Glu Val Leu Ala Ala Ala Lys Glu Asp Phe Met Lys Gln Lys
            900                 905                 910         
Thr Glu Leu Leu Leu Gln Lys Glu Thr Glu Leu Gln Thr Cys Leu Asp
        915                 920                 925             
Gln Ser Arg Arg Glu Trp Thr Met Gln Glu Ala Lys Arg Ile Gln Leu
    930                 935                 940                 
Glu Ile Tyr Gln Tyr Glu Glu Asp Ile Leu Thr Val Leu Gly Val Leu
945                 950                 955                 960 
Leu Ser Asp Thr Gln Lys Glu His Ile Ser Asp Ser Glu Asp Lys Gln
                965                 970                 975     
Leu Leu Glu Ile Met Ser Thr Cys Ser Ser Lys Trp Met Ser Val Gln
            980                 985                 990         
Tyr Phe Glu Lys Leu Lys Gly Cys Ile Gln Lys Ala Phe Gln Asp Thr
        995                 1000                1005            
Leu Pro Leu Leu Val Glu Asn Ala Asp Pro Glu Trp Lys Lys Arg Asn
    1010                1015                1020                
Met Ala Glu Leu Ser Lys Asp Ser Ala Ser Gln Gly Thr Gly Gln Gly
1025                1030                1035                1040
Asp Pro Gly Pro Ala Ala Gly His His Ala Gln Pro Leu Ala Leu Gln
                1045                1050                1055    
Ala Thr Glu Ala Glu Ala Asp Lys Lys Lys Val Leu Glu Ile Lys Asp
            1060                1065                1070        
Leu Cys Cys Gly His Cys Phe Gln Glu Leu Glu Lys Ala Lys Gln Glu
        1075                1080                1085            
Cys Gln Asp Leu Lys Gly Lys Leu Glu Lys Cys Cys Arg His Leu Gln
    1090                1095                1100                
His Leu Glu Arg Lys His Lys Ala Val Val Glu Lys Ile Gly Glu Glu
1105                1110                1115                1120
Asn Asn Lys Val Val Glu Glu Leu Ile Glu Glu Asn Asn Asp Met Lys
                1125                1130                1135    
Asn Lys Leu Glu Glu Leu Gln Thr Leu Cys Lys Thr Pro Pro Arg Ser
            1140                1145                1150        
Leu Ser Ala Gly Ala Ile Glu Asn Ala Cys Leu Pro Cys Ser Gly Gly
        1155                1160                1165            
Ala Leu Glu Glu Leu Arg Gly Gln Tyr Ile Lys Ala Val Lys Lys Ile
    1170                1175                1180                
Lys Cys Asp Met Leu Arg Tyr Ile Gln Glu Ser Lys Glu Arg Ala Ala
1185                1190                1195                1200
Glu Met Val Lys Ala Glu Val Leu Arg Glu Arg Gln Glu Thr Ala Arg
                1205                1210                1215    
Lys Met Arg Lys Tyr Tyr Leu Ile Cys Leu Gln Gln Ile Leu Gln Asp
            1220                1225                1230        
Asp Gly Lys Glu Gly Ala Glu Lys Lys Ile Met Asn Ala Ala Ser Lys
        1235                1240                1245            
Leu Ala Thr Met Ala Lys Leu Leu Glu Thr Pro Ile Ser Ser Lys Ser
    1250                1255                1260                
Gln Ser Lys Thr Thr Gln Ser Gly Met Ser Lys
1265                1270                1275


<210> 2118
<211> 1101
<212> PRT
<213> Homo sapiens

<400> 2118
Met Asp Arg Ala Pro Thr Glu Gln Asn Val Lys Leu Ser Ala Glu Val
 1               5                  10                  15      
Glu Pro Phe Ile Pro Gln Lys Lys Ser Pro Asp Thr Phe Met Ile Pro
            20                  25                  30          
Met Ala Leu Pro Asn Asp Asn Gly Ser Val Ser Gly Val Glu Pro Thr
        35                  40                  45              
Pro Ile Pro Ser Tyr Leu Ile Thr Cys Tyr Pro Phe Val Gln Glu Asn
    50                  55                  60                  
Gln Ser Asn Arg Gln Phe Pro Leu Tyr Asn Asn Asp Ile Arg Trp Gln
65                  70                  75                  80  
Gln Pro Asn Pro Asn Pro Thr Gly Pro Tyr Phe Ala Tyr Pro Ile Ile
                85                  90                  95      
Ser Ala Gln Pro Pro Val Ser Thr Glu Tyr Thr Tyr Tyr Gln Leu Met
            100                 105                 110         
Pro Ala Pro Cys Ala Gln Val Met Gly Phe Tyr His Pro Phe Pro Thr
        115                 120                 125             
Pro Tyr Ser Asn Thr Phe Gln Ala Ala Asn Thr Val Asn Ala Ile Thr
    130                 135                 140                 
Thr Glu Cys Thr Glu Arg Pro Ser Gln Leu Gly Gln Val Phe Pro Leu
145                 150                 155                 160 
Ser Ser His Arg Ser Arg Asn Ser Asn Arg Gly Ser Val Val Pro Lys
                165                 170                 175     
Gln Gln Leu Leu Gln Gln His Ile Lys Ser Lys Arg Pro Leu Val Lys
            180                 185                 190         
Asn Val Ala Thr Gln Lys Glu Thr Asn Ala Ala Gly Pro Asp Ser Arg
        195                 200                 205             
Ser Lys Ile Val Leu Leu Val Asp Ala Ser Gln Gln Thr Asp Phe Pro
    210                 215                 220                 
Ser Asp Ile Ala Asn Lys Ser Leu Ser Glu Thr Thr Ala Thr Met Leu
225                 230                 235                 240 
Trp Lys Ser Lys Gly Arg Arg Arg Arg Ala Ser His Pro Thr Ala Glu
                245                 250                 255     
Ser Ser Ser Glu Gln Gly Ala Ser Glu Ala Asp Ile Asp Ser Asp Ser
            260                 265                 270         
Gly Tyr Cys Ser Pro Lys His Ser Asn Asn Gln Pro Ala Ala Gly Ala
        275                 280                 285             
Leu Arg Asn Pro Asp Ser Gly Thr Met Asn His Val Glu Ser Ser Met
    290                 295                 300                 
Cys Ala Gly Gly Val Asn Trp Ser Asn Val Thr Cys Gln Ala Thr Gln
305                 310                 315                 320 
Lys Lys Pro Trp Met Glu Lys Asn Gln Thr Phe Ser Arg Gly Gly Arg
                325                 330                 335     
Gln Thr Glu Gln Arg Asn Asn Ser Gln Val Gly Phe Arg Cys Arg Gly
            340                 345                 350         
His Ser Thr Ser Ser Glu Arg Arg Gln Asn Leu Gln Lys Arg Pro Asp
        355                 360                 365             
Asn Lys His Leu Ser Ser Ser Gln Ser His Arg Ser Asp Pro Asn Ser
    370                 375                 380                 
Glu Ser Leu Tyr Phe Glu Asp Glu Asp Gly Phe Gln Glu Leu Asn Glu
385                 390                 395                 400 
Asn Gly Asn Ala Lys Asp Glu Asn Ile Gln Gln Lys Leu Ser Ser Lys
                405                 410                 415     
Val Leu Asp Asp Leu Pro Glu Asn Ser Pro Ile Asn Ile Val Gln Thr
            420                 425                 430         
Pro Ile Pro Ile Thr Thr Ser Val Pro Lys Arg Ala Lys Ser Gln Lys
        435                 440                 445             
Lys Lys Ala Leu Ala Ala Ala Leu Ala Thr Ala Gln Glu Tyr Ser Glu
    450                 455                 460                 
Ile Ser Met Glu Gln Lys Lys Leu Gln Glu Ala Leu Ser Lys Ala Ala
465                 470                 475                 480 
Gly Lys Lys Asn Lys Thr Pro Val Gln Leu Asp Leu Gly Asp Met Leu
                485                 490                 495     
Ala Ala Leu Glu Lys Gln Gln Gln Ala Met Lys Ala Arg Gln Ile Thr
            500                 505                 510         
Asn Thr Arg Pro Leu Ser Tyr Thr Val Val Thr Ala Ala Ser Phe His
        515                 520                 525             
Thr Lys Asp Ser Thr Asn Arg Lys Pro Leu Thr Lys Ser Gln Pro Cys
    530                 535                 540                 
Leu Thr Ser Phe Asn Ser Val Asp Ile Ala Ser Ser Lys Ala Lys Lys
545                 550                 555                 560 
Gly Lys Glu Lys Glu Ile Ala Lys Leu Lys Arg Pro Thr Ala Leu Lys
                565                 570                 575     
Lys Val Ile Leu Lys Glu Arg Glu Glu Lys Lys Gly Arg Leu Thr Val
            580                 585                 590         
Asp His Asn Leu Leu Gly Ser Glu Glu Pro Thr Glu Met His Leu Asp
        595                 600                 605             
Phe Ile Asp Asp Leu Pro Gln Glu Ile Val Ser Gln Glu Asp Thr Gly
    610                 615                 620                 
Leu Ser Met Pro Ser Asp Thr Ser Leu Ser Pro Ala Ser Gln Asn Ser
625                 630                 635                 640 
Pro Tyr Cys Met Thr Pro Val Ser Gln Gly Ser Pro Ala Ser Ser Gly
                645                 650                 655     
Ile Gly Ser Pro Met Ala Ser Ser Thr Ile Thr Lys Ile His Ser Lys
            660                 665                 670         
Arg Phe Arg Glu Tyr Cys Asn Gln Val Leu Cys Lys Glu Ile Asp Glu
        675                 680                 685             
Cys Val Thr Leu Leu Leu Gln Glu Leu Val Ser Phe Gln Glu Arg Ile
    690                 695                 700                 
Tyr Gln Lys Asp Pro Val Arg Ala Lys Ala Arg Arg Arg Leu Val Met
705                 710                 715                 720 
Gly Leu Arg Glu Val Thr Lys His Met Lys Leu Asn Lys Ile Lys Cys
                725                 730                 735     
Val Ile Ile Ser Pro Asn Cys Glu Lys Ile Gln Ser Lys Gly Gly Leu
            740                 745                 750         
Asp Glu Ala Leu Tyr Asn Val Ile Ala Met Ala Arg Glu Gln Glu Ile
        755                 760                 765             
Pro Phe Val Phe Ala Leu Gly Arg Lys Ala Leu Gly Arg Cys Val Asn
    770                 775                 780                 
Lys Leu Val Pro Val Ser Val Val Gly Ile Phe Asn Tyr Phe Gly Ala
785                 790                 795                 800 
Glu Ser Leu Phe Asn Lys Leu Val Glu Leu Thr Glu Glu Ala Arg Lys
                805                 810                 815     
Ala Tyr Lys Asp Met Val Ala Ala Met Glu Gln Glu Gln Ala Glu Glu
            820                 825                 830         
Ala Leu Lys Asn Val Lys Lys Val Pro His His Met Gly His Ser Arg
        835                 840                 845             
Asn Pro Ser Ala Ala Ser Ala Ile Ser Phe Cys Ser Val Ile Ser Glu
    850                 855                 860                 
Pro Ile Ser Glu Val Asn Glu Lys Glu Tyr Glu Thr Asn Trp Arg Asn
865                 870                 875                 880 
Met Val Glu Thr Ser Asp Gly Leu Glu Ala Ser Glu Asn Glu Lys Glu
                885                 890                 895     
Val Ser Cys Lys His Ser Thr Ser Glu Lys Pro Ser Lys Leu Pro Phe
            900                 905                 910         
Asp Thr Pro Pro Ile Gly Lys Gln Pro Ser Leu Val Ala Thr Gly Ser
        915                 920                 925             
Thr Thr Ser Ala Thr Ser Ala Gly Lys Ser Thr Ala Ser Asp Lys Glu
    930                 935                 940                 
Glu Val Lys Pro Asp Asp Leu Glu Trp Ala Ser Gln Gln Ser Thr Glu
945                 950                 955                 960 
Thr Gly Ser Leu Asp Gly Ser Cys Arg Asp Leu Leu Asn Ser Ser Ile
                965                 970                 975     
Thr Ser Thr Thr Ser Thr Leu Val Pro Gly Met Leu Glu Glu Glu Glu
            980                 985                 990         
Asp Glu Asp Glu Glu Glu Glu Glu Asp Tyr Thr His Glu Pro Ile Ser
        995                 1000                1005            
Val Glu Val Gln Leu Asn Ser Arg Ile Glu Ser Trp Val Ser Glu Thr
    1010                1015                1020                
Gln Arg Thr Met Glu Thr Leu Gln Leu Gly Lys Thr Leu Asn Gly Ser
1025                1030                1035                1040
Glu Glu Asp Asn Val Glu Gln Ser Gly Glu Glu Glu Ala Glu Ala Pro
                1045                1050                1055    
Glu Val Leu Glu Pro Gly Met Asp Ser Glu Ala Trp Thr Ala Asp Gln
            1060                1065                1070        
Gln Ala Ser Pro Gly Gln Gln Lys Ser Ser Asn Cys Ser Ser Leu Asn
        1075                1080                1085            
Lys Glu His Ser Asp Ser Asn Tyr Thr Thr Gln Thr Thr
    1090                1095                1100    


<210> 2119
<211> 1114
<212> PRT
<213> Homo sapiens

<400> 2119
Met Leu Lys Thr Glu Lys Thr Lys Pro Glu Val Leu Glu Ala His Tyr
 1               5                  10                  15      
Gly Ser Ala Glu Pro Glu Lys Val Leu Arg Val Leu His Arg Asp Ala
            20                  25                  30          
Ile Leu Ala Gln Glu Lys Ser Ile Gly Glu Asp Val Tyr Glu Lys Pro
        35                  40                  45              
Ile Ser Glu Leu Asp Arg Leu Glu Glu Lys Gln Lys Glu Thr Tyr Arg
    50                  55                  60                  
Arg Met Leu Glu Gln Leu Leu Leu Ala Glu Lys Cys His Arg Arg Thr
65                  70                  75                  80  
Val Tyr Glu Leu Glu Asn Glu Lys His Lys His Thr Asp Tyr Met Asn
                85                  90                  95      
Lys Ser Asp Asp Phe Thr Asn Leu Leu Glu Gln Glu Arg Glu Arg Leu
            100                 105                 110         
Lys Lys Leu Leu Glu Gln Glu Lys Ala Tyr Gln Ala Arg Lys Glu Lys
        115                 120                 125             
Glu Asn Ala Lys Arg Leu Asn Lys Leu Arg Asp Glu Leu Val Lys Leu
    130                 135                 140                 
Lys Ser Phe Ala Leu Met Leu Val Asp Glu Arg Gln Met His Ile Glu
145                 150                 155                 160 
Gln Leu Gly Leu Gln Ser Gln Lys Val Gln Asp Leu Thr Gln Lys Leu
                165                 170                 175     
Arg Glu Glu Glu Glu Lys Leu Lys Ala Ile Thr Ser Lys Ser Lys Glu
            180                 185                 190         
Asp Arg Gln Lys Leu Leu Lys Leu Glu Val Asp Phe Glu His Lys Ala
        195                 200                 205             
Ser Arg Phe Ser Gln Glu His Glu Glu Met Asn Ala Lys Leu Ala Asn
    210                 215                 220                 
Gln Glu Ser His Asn Arg Gln Leu Arg Leu Lys Leu Val Gly Leu Thr
225                 230                 235                 240 
Gln Arg Ile Glu Glu Leu Glu Glu Thr Asn Lys Asn Leu Gln Lys Ala
                245                 250                 255     
Glu Glu Glu Leu Gln Glu Leu Arg Asp Lys Ile Ala Lys Gly Glu Cys
            260                 265                 270         
Gly Asn Ser Ser Leu Met Ala Glu Val Glu Asn Leu Arg Lys Arg Val
        275                 280                 285             
Leu Glu Met Glu Gly Lys Asp Glu Glu Ile Thr Lys Thr Glu Ser Gln
    290                 295                 300                 
Cys Arg Glu Leu Arg Lys Lys Leu Gln Glu Glu Glu His His Ser Lys
305                 310                 315                 320 
Glu Leu Arg Leu Glu Val Glu Lys Leu Gln Lys Arg Met Ser Glu Leu
                325                 330                 335     
Glu Lys Leu Glu Glu Ala Phe Ser Lys Ser Lys Ser Glu Cys Thr Gln
            340                 345                 350         
Leu His Leu Asn Leu Glu Lys Glu Lys Asn Leu Thr Lys Asp Leu Leu
        355                 360                 365             
Asn Glu Leu Glu Val Val Lys Ser Arg Val Lys Glu Leu Glu Cys Ser
    370                 375                 380                 
Glu Ser Arg Leu Glu Lys Ala Glu Leu Ser Leu Lys Asp Asp Leu Thr
385                 390                 395                 400 
Lys Leu Lys Ser Phe Thr Val Met Leu Val Asp Glu Arg Lys Asn Met
                405                 410                 415     
Met Glu Lys Ile Lys Gln Glu Glu Arg Lys Val Asp Gly Leu Asn Lys
            420                 425                 430         
Asn Phe Lys Val Glu Gln Gly Lys Val Met Asp Val Thr Glu Lys Leu
        435                 440                 445             
Ile Glu Glu Ser Lys Lys Leu Leu Lys Leu Lys Ser Glu Met Glu Glu
    450                 455                 460                 
Lys Val Tyr Asn Leu Thr Arg Glu Arg Asp Glu Leu Ile Gly Lys Leu
465                 470                 475                 480 
Lys Ser Glu Glu Glu Lys Ser Ser Glu Leu Ser Cys Ser Val Asp Leu
                485                 490                 495     
Leu Lys Lys Arg Leu Asp Gly Ile Glu Glu Val Glu Arg Glu Ile Thr
            500                 505                 510         
Arg Gly Arg Ser Arg Lys Gly Ser Glu Leu Thr Cys Pro Glu Asp Asn
        515                 520                 525             
Lys Ile Lys Glu Leu Thr Leu Glu Ile Glu Arg Leu Lys Lys Arg Leu
    530                 535                 540                 
Gln Gln Leu Glu Val Val Glu Gly Asp Leu Met Lys Thr Glu Asp Glu
545                 550                 555                 560 
Tyr Asp Gln Leu Glu Gln Lys Phe Arg Thr Glu Gln Asp Lys Ala Asn
                565                 570                 575     
Phe Leu Ser Gln Gln Leu Glu Glu Ile Lys His Gln Ile Ala Lys Asn
            580                 585                 590         
Lys Ala Ile Glu Lys Gly Glu Val Val Ser Gln Glu Ala Glu Leu Arg
        595                 600                 605             
His Arg Phe Arg Leu Glu Glu Ala Lys Ser Arg Asp Leu Lys Ala Glu
    610                 615                 620                 
Val Gln Ala Leu Lys Glu Lys Ile His Glu Leu Met Asn Lys Glu Asp
625                 630                 635                 640 
Gln Leu Ser Gln Leu Gln Val Asp Tyr Ser Val Leu Gln Gln Arg Phe
                645                 650                 655     
Met Glu Glu Glu Asn Lys Asn Lys Asn Met Gly Gln Glu Val Leu Asn
            660                 665                 670         
Leu Thr Lys Glu Leu Glu Leu Ser Lys Arg Tyr Ser Arg Ala Leu Arg
        675                 680                 685             
Pro Ser Val Asn Gly Arg Arg Met Val Asp Val Pro Val Thr Ser Thr
    690                 695                 700                 
Gly Val Gln Thr Asp Ala Val Ser Gly Glu Ala Ala Glu Glu Glu Thr
705                 710                 715                 720 
Pro Ala Val Phe Ile Arg Lys Ser Phe Gln Glu Glu Asn His Ile Met
                725                 730                 735     
Ser Asn Leu Arg Gln Val Gly Leu Lys Lys Pro Val Glu Arg Ser Ser
            740                 745                 750         
Val Leu Asp Arg Tyr Pro Pro Ala Ala Asn Glu Leu Thr Met Arg Lys
        755                 760                 765             
Ser Trp Ile Pro Trp Met Arg Lys Arg Glu Asn Gly Pro Ser Ile Thr
    770                 775                 780                 
Gln Glu Lys Gly Pro Arg Thr Asn Ser Ser Pro Gly His Pro Gly Glu
785                 790                 795                 800 
Val Val Leu Ser Pro Lys Gln Gly Gln Pro Leu His Ile Arg Val Thr
                805                 810                 815     
Pro Asp His Glu Asn Ser Thr Ala Thr Leu Glu Ile Thr Ser Pro Thr
            820                 825                 830         
Ser Glu Glu Phe Phe Ser Ser Thr Thr Val Ile Pro Thr Leu Gly Asn
        835                 840                 845             
Gln Lys Pro Arg Ile Thr Ile Ile Pro Ser Pro Asn Val Met Pro Gln
    850                 855                 860                 
Lys Gln Lys Ser Gly Asp Thr Thr Leu Gly Pro Glu Arg Ala Met Ser
865                 870                 875                 880 
Pro Val Thr Ile Thr Thr Phe Ser Arg Glu Lys Thr Pro Glu Ser Gly
                885                 890                 895     
Arg Gly Ala Phe Ala Asp Arg Pro Thr Ser Pro Ile Gln Ile Met Thr
            900                 905                 910         
Val Ser Thr Ser Ala Ala Pro Ala Glu Ile Ala Val Ser Pro Glu Ser
        915                 920                 925             
Gln Glu Met Pro Met Gly Arg Thr Ile Leu Lys Val Thr Pro Glu Lys
    930                 935                 940                 
Gln Thr Val Pro Thr Pro Val Arg Lys Tyr Asn Ser Asn Ala Asn Ile
945                 950                 955                 960 
Ile Thr Thr Glu Asp Asn Lys Ile His Ile His Leu Gly Ser Gln Phe
                965                 970                 975     
Lys Arg Ser Pro Gly Thr Ser Gly Glu Gly Val Ser Pro Val Ile Thr
            980                 985                 990         
Val Arg Pro Val Asn Val Thr Ala Glu Lys Glu Val Ser Thr Gly Thr
        995                 1000                1005            
Val Leu Arg Ser Pro Arg Asn His Leu Ser Ser Arg Pro Gly Ala Ser
    1010                1015                1020                
Lys Val Thr Ser Thr Ile Thr Ile Thr Pro Val Thr Thr Ser Ser Ala
1025                1030                1035                1040
Arg Gly Thr Gln Ser Val Ser Gly Gln Asp Gly Ser Ser Gln Arg Pro
                1045                1050                1055    
Thr Pro Thr Arg Ile Pro Met Ser Lys Gly Met Lys Ala Gly Lys Pro
            1060                1065                1070        
Val Val Ala Ala Pro Gly Ala Gly Asn Leu Thr Lys Phe Glu Pro Arg
        1075                1080                1085            
Ala Glu Thr Gln Ser Met Lys Ile Glu Leu Lys Lys Ser Ala Ala Ser
    1090                1095                1100                
Ser Thr Thr Ser Leu Gly Gly Gly Lys Gly
1105                1110                


<210> 2120
<211> 756
<212> PRT
<213> Homo sapiens

<400> 2120
Met Ser Pro Gln Lys Arg Val Lys Asn Val Gln Ala Gln Asn Arg Thr
 1               5                  10                  15      
Ser Gln Gly Ser Ser Ser Phe Gln Thr Thr Leu Ser Ala Trp Lys Val
            20                  25                  30          
Lys Gln Asp Pro Ser Asn Ser Lys Asn Ile Ser Lys His Gly Gln Asn
        35                  40                  45              
Asn Pro Val Gly Asp Tyr Glu His Ala Asp Asp Gln Ala Glu Glu Asp
    50                  55                  60                  
Ala Leu Gln Met Ala Val Gly Tyr Phe Glu Lys Gly Pro Ile Lys Ala
65                  70                  75                  80  
Ser Gln Asn Lys Asp Lys Thr Leu Glu Lys His Leu Lys Thr Val Glu
                85                  90                  95      
Asn Val Ala Trp Lys Asn Gly Leu Ala Ser Glu Glu Ile Asp Ile Leu
            100                 105                 110         
Leu Asn Ile Ala Leu Ser Gly Lys Phe Gly Asn Ala Val Asn Thr Arg
        115                 120                 125             
Ile Leu Lys Cys Met Ile Pro Ala Thr Val Ile Ser Glu Asp Ser Val
    130                 135                 140                 
Val Lys Ala Val Ser Trp Leu Cys Val Gly Lys Cys Ser Gly Ser Thr
145                 150                 155                 160 
Lys Val Leu Phe Tyr Arg Trp Leu Val Ala Met Phe Asp Phe Ile Asp
                165                 170                 175     
Arg Lys Glu Gln Ile Asn Leu Leu Tyr Gly Phe Phe Phe Ala Ser Leu
            180                 185                 190         
Gln Asp Asp Ala Leu Cys Pro Tyr Val Cys His Leu Leu Tyr Leu Leu
        195                 200                 205             
Thr Lys Lys Glu Asn Val Lys Pro Phe Arg Val Arg Lys Leu Leu Asp
    210                 215                 220                 
Leu Gln Ala Lys Met Gly Met Gln Pro His Leu Gln Ala Leu Leu Ser
225                 230                 235                 240 
Leu Tyr Lys Phe Phe Ala Pro Ala Leu Ile Ser Val Ser Leu Pro Val
                245                 250                 255     
Arg Lys Lys Ile Tyr Phe Lys Asn Ser Glu Asn Leu Trp Lys Thr Ala
            260                 265                 270         
Leu Leu Ala Val Lys Gln Arg Asn Arg Gly Pro Ser Pro Glu Pro Leu
        275                 280                 285             
Lys Leu Met Leu Gly Pro Ala Asn Val Arg Pro Leu Lys Arg Lys Trp
    290                 295                 300                 
Asn Ser Leu Ser Val Ile Pro Val Leu Asn Ser Ser Ser Tyr Thr Lys
305                 310                 315                 320 
Glu Cys Gly Lys Lys Glu Met Ser Leu Ser Asp Cys Leu Asn Arg Ser
                325                 330                 335     
Gly Ser Phe Pro Leu Glu Gln Leu Gln Ser Phe Pro Gln Leu Leu Gln
            340                 345                 350         
Asn Ile His Cys Leu Glu Leu Pro Ser Gln Met Gly Ser Val Leu Asn
        355                 360                 365             
Asn Ser Leu Leu Leu His Tyr Ile Asn Cys Val Arg Asp Glu Pro Val
    370                 375                 380                 
Leu Leu Arg Phe Tyr Tyr Trp Leu Ser Gln Thr Leu Gln Glu Glu Cys
385                 390                 395                 400 
Ile Trp Tyr Lys Val Asn Asn Tyr Glu His Gly Lys Glu Phe Thr Asn
                405                 410                 415     
Phe Leu Asp Thr Ile Ile Arg Ala Glu Cys Phe Leu Gln Glu Gly Phe
            420                 425                 430         
Tyr Ser Cys Glu Ala Phe Leu Tyr Lys Ser Leu Pro Leu Trp Asp Gly
        435                 440                 445             
Leu Cys Cys Arg Ser Gln Phe Leu Gln Leu Val Ser Trp Ile Pro Phe
    450                 455                 460                 
Ser Ser Phe Ser Glu Val Lys Pro Leu Leu Phe Asp His Leu Ala Gln
465                 470                 475                 480 
Leu Phe Phe Thr Ser Thr Ile Tyr Phe Lys Cys Ser Val Leu Gln Ser
                485                 490                 495     
Leu Lys Glu Leu Leu Gln Asn Trp Leu Leu Trp Leu Ser Met Asp Ile
            500                 505                 510         
His Met Lys Pro Val Thr Asn Ser Pro Leu Glu Thr Thr Leu Gly Gly
        515                 520                 525             
Ser Met Asn Ser Val Ser Lys Leu Ile His Tyr Val Gly Trp Leu Ser
    530                 535                 540                 
Thr Thr Ala Met Arg Leu Glu Ser Asn Asn Thr Phe Leu Leu His Phe
545                 550                 555                 560 
Ile Leu Asp Phe Tyr Glu Lys Val Cys Asp Ile Tyr Ile Asn Tyr Asn
                565                 570                 575     
Leu Pro Leu Val Val Leu Phe Pro Pro Gly Ile Phe Tyr Ser Ala Leu
            580                 585                 590         
Leu Ser Leu Asp Thr Ser Ile Leu Asn Gln Leu Cys Phe Ile Met His
        595                 600                 605             
Arg Tyr Arg Lys Asn Leu Thr Ala Ala Lys Lys Asn Glu Leu Val Gln
    610                 615                 620                 
Lys Thr Lys Ser Glu Phe Asn Phe Ser Ser Lys Thr Tyr Gln Glu Phe
625                 630                 635                 640 
Asn His Tyr Leu Thr Ser Met Val Gly Cys Leu Trp Thr Ser Lys Pro
                645                 650                 655     
Phe Gly Lys Gly Ile Tyr Ile Asp Pro Glu Ile Leu Glu Lys Thr Gly
            660                 665                 670         
Val Ala Glu Tyr Lys Asn Ser Leu Asn Val Val His His Pro Ser Phe
        675                 680                 685             
Leu Ser Tyr Ala Val Ser Phe Leu Leu Gln Glu Ser Pro Glu Glu Arg
    690                 695                 700                 
Thr Val Asn Val Ser Ser Ile Arg Gly Lys Lys Trp Ser Trp Tyr Leu
705                 710                 715                 720 
Asp Tyr Leu Phe Ser Gln Gly Leu Gln Gly Leu Lys Leu Phe Ile Arg
                725                 730                 735     
Ser Ser Val His His Ser Ser Ile Pro Arg Ala Glu Gly Ile Asn Cys
            740                 745                 750         
Asn Asn Gln Tyr
        755     


<210> 2121
<211> 389
<212> PRT
<213> Homo sapiens

<400> 2121
Met Lys Asn Asn Gln Ile Thr Asn Asn Gln Arg Ile Lys Ala Ala Val
 1               5                  10                  15      
Pro Ser Ile Lys Phe Cys Leu Asp Asn Gly Ala Lys Ser Val Val Leu
            20                  25                  30          
Met Ser His Leu Gly Arg Pro Asp Gly Val Pro Met Pro Asp Lys Tyr
        35                  40                  45              
Ser Leu Glu Pro Val Ala Val Glu Leu Lys Ser Leu Leu Gly Lys Asp
    50                  55                  60                  
Val Leu Phe Leu Lys Asp Cys Val Gly Pro Glu Val Glu Lys Ala Cys
65                  70                  75                  80  
Ala Asn Pro Ala Ala Gly Ser Val Ile Leu Leu Glu Asn Leu Arg Phe
                85                  90                  95      
His Val Glu Glu Glu Gly Lys Gly Lys Asp Ala Ser Gly Asn Lys Val
            100                 105                 110         
Lys Ala Glu Pro Ala Lys Ile Glu Ala Phe Arg Ala Ser Leu Ser Lys
        115                 120                 125             
Leu Gly Asp Val Tyr Val Asn Asp Ala Phe Gly Thr Ala His Arg Ala
    130                 135                 140                 
His Ser Ser Met Val Gly Val Asn Leu Pro Gln Lys Ala Gly Gly Phe
145                 150                 155                 160 
Leu Met Lys Lys Glu Leu Asn Tyr Phe Ala Lys Ala Leu Glu Ser Pro
                165                 170                 175     
Glu Arg Pro Phe Leu Ala Ile Leu Gly Gly Ala Lys Val Ala Asp Lys
            180                 185                 190         
Ile Gln Leu Ile Asn Asn Met Leu Asp Lys Val Asn Glu Met Ile Ile
        195                 200                 205             
Gly Gly Gly Met Ala Phe Thr Phe Leu Lys Val Leu Asn Asn Met Glu
    210                 215                 220                 
Ile Gly Thr Ser Leu Phe Asp Glu Glu Gly Ala Lys Ile Val Lys Asp
225                 230                 235                 240 
Leu Met Ser Lys Ala Glu Lys Asn Gly Val Lys Ile Thr Leu Pro Val
                245                 250                 255     
Asp Phe Val Thr Ala Asp Lys Phe Asp Glu Asn Ala Lys Thr Gly Gln
            260                 265                 270         
Ala Thr Val Ala Ser Gly Ile Pro Ala Gly Trp Met Gly Leu Asp Cys
        275                 280                 285             
Gly Pro Glu Ser Ser Lys Lys Tyr Ala Glu Ala Val Thr Arg Ala Lys
    290                 295                 300                 
Gln Ile Val Trp Asn Gly Pro Val Gly Val Phe Glu Trp Glu Ala Phe
305                 310                 315                 320 
Ala Arg Gly Thr Lys Ala Leu Met Asp Glu Val Val Lys Ala Thr Ser
                325                 330                 335     
Arg Gly Cys Ile Thr Ile Ile Gly Gly Gly Asp Thr Ala Thr Cys Cys
            340                 345                 350         
Ala Lys Trp Asn Thr Glu Asp Lys Val Ser His Val Ser Thr Gly Gly
        355                 360                 365             
Gly Ala Ser Leu Glu Leu Leu Glu Gly Lys Val Leu Pro Gly Val Asp
    370                 375                 380                 
Ala Leu Ser Asn Ile
385                 


<210> 2122
<211> 1299
<212> PRT
<213> Homo sapiens

<400> 2122
Met Glu Pro Pro Ser Cys Ile Gln Asp Glu Pro Phe Pro His Pro Leu
 1               5                  10                  15      
Glu Pro Glu Pro Gly Val Ser Ala Gln Pro Gly Pro Gly Lys Pro Ser
            20                  25                  30          
Asp Lys Arg Phe Arg Leu Trp Tyr Val Gly Gly Ser Cys Leu Asp His
        35                  40                  45              
Arg Thr Thr Leu Pro Met Leu Pro Trp Leu Met Ala Glu Ile Arg Arg
    50                  55                  60                  
Arg Ser Gln Lys Pro Glu Ala Gly Gly Cys Gly Ala Pro Ala Ala Arg
65                  70                  75                  80  
Glu Val Ile Leu Val Leu Ser Ala Pro Phe Leu Arg Cys Val Pro Ala
                85                  90                  95      
Pro Gly Ala Gly Ala Ser Gly Gly Thr Ser Pro Ser Ala Thr Gln Pro
            100                 105                 110         
Asn Pro Ala Val Phe Ile Phe Glu His Lys Ala Gln His Ile Ser Arg
        115                 120                 125             
Phe Ile His Asn Ser His Asp Leu Thr Tyr Phe Ala Tyr Leu Ile Lys
    130                 135                 140                 
Ala Gln Pro Asp Asp Pro Glu Ser Gln Met Ala Cys His Val Phe Arg
145                 150                 155                 160 
Ala Thr Asp Pro Ser Gln Val Pro Asp Val Ile Ser Ser Ile Arg Gln
                165                 170                 175     
Leu Ser Lys Ala Ala Met Lys Glu Asp Ala Lys Pro Ser Lys Asp Asn
            180                 185                 190         
Glu Asp Ala Phe Tyr Asn Ser Gln Lys Phe Glu Val Leu Tyr Cys Gly
        195                 200                 205             
Lys Val Thr Val Thr His Lys Lys Ala Pro Ser Ser Leu Ile Asp Asp
    210                 215                 220                 
Cys Met Glu Lys Phe Ser Leu His Glu Gln Gln Arg Leu Lys Ile Gln
225                 230                 235                 240 
Gly Glu Gln Arg Gly Pro Asp Pro Gly Glu Asp Leu Ala Asp Leu Glu
                245                 250                 255     
Val Val Val Pro Gly Ser Pro Gly Asp Cys Leu Pro Glu Glu Ala Asp
            260                 265                 270         
Gly Thr Asp Thr His Leu Gly Leu Pro Ala Gly Ala Ser Gln Pro Ala
        275                 280                 285             
Leu Thr Ser Ser Arg Val Cys Phe Pro Glu Arg Ile Leu Glu Asp Ser
    290                 295                 300                 
Gly Phe Asp Glu Gln Gln Glu Phe Arg Ser Arg Cys Ser Ser Val Thr
305                 310                 315                 320 
Gly Val Gln Arg Arg Val His Glu Gly Ser Gln Lys Ser Gln Pro Arg
                325                 330                 335     
Arg Arg His Ala Ser Ala Pro Ser His Val Gln Pro Ser Asp Ser Glu
            340                 345                 350         
Lys Asn Arg Thr Met Leu Phe Gln Val Gly Arg Phe Glu Ile Asn Leu
        355                 360                 365             
Ile Ser Pro Asp Thr Lys Ser Val Val Leu Glu Lys Asn Phe Lys Asp
    370                 375                 380                 
Ile Ser Ser Cys Ser Gln Gly Ile Lys His Val Asp His Phe Gly Phe
385                 390                 395                 400 
Ile Cys Arg Glu Ser Pro Glu Pro Gly Leu Ser Gln Tyr Ile Cys Tyr
                405                 410                 415     
Val Phe Gln Cys Ala Ser Glu Ser Leu Val Asp Glu Val Met Leu Thr
            420                 425                 430         
Leu Lys Gln Ala Phe Ser Thr Ala Ala Ala Leu Gln Ser Ala Lys Thr
        435                 440                 445             
Gln Ile Lys Leu Cys Glu Ala Cys Pro Met His Ser Leu His Lys Leu
    450                 455                 460                 
Cys Glu Arg Ile Glu Gly Leu Tyr Pro Pro Arg Ala Lys Leu Val Ile
465                 470                 475                 480 
Gln Arg His Leu Ser Ser Leu Thr Asp Asn Glu Gln Ala Asp Ile Phe
                485                 490                 495     
Glu Arg Val Gln Lys Met Lys Pro Val Ser Asp Gln Glu Glu Asn Glu
            500                 505                 510         
Leu Val Ile Leu His Leu Arg Gln Leu Cys Glu Ala Lys Gln Lys Thr
        515                 520                 525             
His Val His Ile Gly Glu Gly Pro Ser Thr Ile Ser Asn Ser Thr Ile
    530                 535                 540                 
Pro Glu Asn Ala Thr Ser Ser Gly Arg Phe Lys Leu Asp Ile Leu Lys
545                 550                 555                 560 
Asn Lys Ala Lys Arg Ser Leu Thr Ser Ser Leu Glu Asn Ile Phe Ser
                565                 570                 575     
Arg Gly Ala Asn Arg Met Arg Gly Arg Leu Gly Ser Val Asp Ser Phe
            580                 585                 590         
Glu Arg Ser Asn Ser Leu Ala Ser Glu Lys Asp Tyr Ser Pro Gly Asp
        595                 600                 605             
Ser Pro Pro Gly Thr Pro Pro Ala Ser Pro Pro Ser Ser Ala Trp Gln
    610                 615                 620                 
Thr Phe Pro Glu Glu Asp Ser Asp Ser Pro Gln Phe Arg Arg Arg Ala
625                 630                 635                 640 
His Thr Phe Ser His Pro Pro Ser Ser Thr Lys Arg Lys Leu Asn Leu
                645                 650                 655     
Gln Asp Gly Arg Ala Gln Gly Val Arg Ser Pro Leu Leu Arg Gln Ser
            660                 665                 670         
Ser Ser Glu Gln Cys Ser Asn Leu Ser Ser Val Arg Arg Met Tyr Lys
        675                 680                 685             
Glu Ser Asn Ser Ser Ser Ser Leu Pro Ser Leu His Thr Ser Phe Ser
    690                 695                 700                 
Ala Pro Ser Phe Thr Ala Pro Ser Phe Leu Lys Ser Phe Tyr Gln Asn
705                 710                 715                 720 
Ser Gly Arg Leu Ser Pro Gln Tyr Glu Asn Glu Ile Arg Gln Asp Thr
                725                 730                 735     
Ala Ser Glu Ser Ser Asp Gly Glu Gly Arg Lys Arg Thr Ser Ser Thr
            740                 745                 750         
Cys Ser Asn Glu Ser Leu Ser Val Gly Gly Thr Ser Val Thr Pro Arg
        755                 760                 765             
Arg Ile Ser Trp Arg Gln Arg Ile Phe Leu Arg Val Ala Ser Pro Met
    770                 775                 780                 
Asn Lys Ser Pro Ser Ala Met Gln Gln Gln Asp Gly Leu Asp Arg Asn
785                 790                 795                 800 
Glu Leu Leu Pro Leu Ser Pro Leu Ser Pro Thr Met Glu Glu Glu Pro
                805                 810                 815     
Leu Val Val Phe Leu Ser Gly Glu Asp Asp Pro Glu Lys Ile Glu Glu
            820                 825                 830         
Arg Lys Lys Ser Lys Glu Leu Arg Ser Leu Trp Arg Lys Ala Ile His
        835                 840                 845             
Gln Gln Ile Leu Leu Leu Arg Met Glu Lys Glu Asn Gln Lys Leu Glu
    850                 855                 860                 
Gly Ala Ser Arg Asp Glu Leu Gln Ser Arg Lys Val Lys Leu Asp Tyr
865                 870                 875                 880 
Glu Glu Val Gly Ala Cys Gln Lys Glu Val Leu Ile Thr Trp Asp Lys
                885                 890                 895     
Lys Leu Leu Asn Cys Arg Ala Lys Ile Arg Cys Asp Met Glu Asp Ile
            900                 905                 910         
His Thr Leu Leu Lys Glu Gly Val Pro Lys Ser Arg Arg Gly Glu Ile
        915                 920                 925             
Trp Gln Phe Leu Ala Leu Gln Tyr Arg Leu Arg His Arg Leu Pro Asn
    930                 935                 940                 
Lys Gln Gln Pro Pro Asp Ile Ser Tyr Lys Glu Leu Leu Lys Gln Leu
945                 950                 955                 960 
Thr Ala Gln Gln His Ala Ile Leu Val Asp Leu Gly Arg Thr Phe Pro
                965                 970                 975     
Thr His Pro Tyr Phe Ser Val Gln Leu Gly Pro Gly Gln Leu Ser Leu
            980                 985                 990         
Phe Asn Leu Leu Lys Ala Tyr Ser Leu Leu Asp Lys Glu Val Gly Tyr
        995                 1000                1005            
Cys Gln Gly Ile Ser Phe Val Ala Gly Val Leu Leu Leu His Met Ser
    1010                1015                1020                
Glu Glu Gln Ala Phe Glu Met Leu Lys Phe Leu Met Tyr Asp Leu Gly
1025                1030                1035                1040
Phe Arg Lys Gln Tyr Arg Pro Asp Met Met Ser Leu Gln Ile Gln Met
                1045                1050                1055    
Tyr Gln Leu Ser Arg Leu Leu His Asp Tyr His Arg Asp Leu Tyr Asn
            1060                1065                1070        
His Leu Glu Glu Asn Glu Ile Ser Pro Ser Leu Tyr Ala Ala Pro Trp
        1075                1080                1085            
Phe Leu Thr Leu Phe Ala Ser Gln Phe Ser Leu Gly Phe Val Ala Arg
    1090                1095                1100                
Val Phe Asp Ile Ile Phe Leu Gln Gly Thr Glu Val Ile Phe Lys Val
1105                1110                1115                1120
Ala Leu Ser Leu Leu Ser Ser Gln Glu Thr Leu Ile Met Glu Cys Glu
                1125                1130                1135    
Ser Phe Glu Asn Ile Val Glu Phe Leu Lys Asn Thr Leu Pro Asp Met
            1140                1145                1150        
Asn Thr Ser Glu Met Glu Lys Ile Ile Thr Gln Val Phe Glu Met Asp
        1155                1160                1165            
Ile Ser Lys Gln Leu His Ala Tyr Glu Val Glu Tyr His Val Leu Gln
    1170                1175                1180                
Asp Glu Leu Gln Glu Ser Ser Tyr Ser Cys Glu Asp Ser Glu Thr Leu
1185                1190                1195                1200
Glu Lys Leu Glu Arg Ala Asn Ser Gln Leu Lys Arg Gln Asn Met Asp
                1205                1210                1215    
Leu Leu Glu Lys Leu Gln Val Ala His Thr Lys Ile Gln Ala Leu Glu
            1220                1225                1230        
Ser Asn Leu Glu Asn Leu Leu Thr Arg Glu Thr Lys Met Lys Ser Leu
        1235                1240                1245            
Ile Arg Thr Leu Glu Gln Glu Lys Met Ala Tyr Gln Lys Thr Val Glu
    1250                1255                1260                
Gln Leu Arg Lys Leu Leu Pro Ala Asp Ala Leu Val Asn Cys Asp Leu
1265                1270                1275                1280
Leu Leu Arg Asp Leu Asn Cys Asn Pro Asn Asn Lys Ala Lys Ile Gly
                1285                1290                1295    
Asn Lys Pro
            


<210> 2123
<211> 220
<212> PRT
<213> Homo sapiens

<400> 2123
Met Gln Asn Gly Ala Gly Gly Ala Leu Phe Val His Arg Asp Thr Pro
 1               5                  10                  15      
Glu Asn Asn Pro Asp Thr Pro Phe Asp Phe Thr Pro Glu Asn Tyr Lys
            20                  25                  30          
Arg Ile Glu Ala Ile Val Lys Asn Tyr Pro Glu Gly His Lys Ala Ala
        35                  40                  45              
Ala Val Leu Pro Val Leu Asp Leu Ala Gln Arg Gln Asn Gly Trp Leu
    50                  55                  60                  
Pro Ile Ser Ala Met Asn Lys Val Ala Glu Val Leu Gln Val Pro Pro
65                  70                  75                  80  
Ile Arg Val Tyr Glu Val Ala Thr Phe Tyr Thr Met Tyr Asn Arg Lys
                85                  90                  95      
Pro Val Glu Lys Tyr His Ile Gln Val Cys Thr Thr Thr Pro Cys Met
            100                 105                 110         
Leu Pro Asn Ser Asp Ser Ile Leu Glu Ala Ile Gln Lys Lys Leu Gly
        115                 120                 125             
Ile Lys Leu Gly Glu Thr Thr Pro Asp Lys Leu Phe Thr Leu Val Glu
    130                 135                 140                 
Val Glu Cys Leu Gly Ala Cys Val Asn Ala Pro Met Val Gln Ile Asn
145                 150                 155                 160 
Asp Asn Tyr Tyr Glu Asp Leu Thr Ala Lys Asp Ile Glu Glu Ile Ile
                165                 170                 175     
Asp Glu Leu Lys Ala Gly Lys Ile Pro Lys Pro Gly Pro Arg Ser Gly
            180                 185                 190         
Arg Phe Ser Cys Glu Pro Ala Gly Gly Leu Thr Pro Leu Thr Glu Pro
        195                 200                 205             
Pro Lys Gly Pro Gly Phe Gly Ile Gln Ala Gly Leu
    210                 215                 220 


<210> 2124
<211> 1328
<212> PRT
<213> Homo sapiens

<400> 2124
Met Pro Glu Gln Glu Arg Gln Ile Thr Ala Arg Glu Gly Ala Ser Arg
 1               5                  10                  15      
Lys Ile Leu Ser Lys Leu Ser Leu Pro Thr Arg Ala Trp Glu Pro Ala
            20                  25                  30          
Met Lys Lys Ser Phe Ala Phe Asp Asn Val Gly Tyr Glu Gly Gly Leu
        35                  40                  45              
Asp Gly Leu Gly Pro Ser Ser Gln Val Ala Thr Ser Thr Val Arg Ile
    50                  55                  60                  
Leu Gly Met Thr Cys Gln Ser Cys Val Lys Ser Ile Glu Asp Arg Ile
65                  70                  75                  80  
Ser Asn Leu Lys Gly Ile Ile Ser Met Lys Val Ser Leu Glu Gln Gly
                85                  90                  95      
Ser Ala Thr Val Lys Tyr Val Pro Ser Val Val Cys Leu Gln Gln Val
            100                 105                 110         
Cys His Gln Ile Gly Asp Met Gly Phe Glu Ala Ser Ile Ala Glu Gly
        115                 120                 125             
Lys Ala Ala Ser Trp Pro Ser Arg Ser Leu Pro Ala Gln Glu Ala Val
    130                 135                 140                 
Val Lys Leu Arg Val Glu Gly Met Thr Cys Gln Ser Cys Val Ser Ser
145                 150                 155                 160 
Ile Glu Gly Lys Val Arg Lys Leu Gln Gly Val Val Arg Val Lys Val
                165                 170                 175     
Ser Leu Ser Asn Gln Glu Ala Val Ile Thr Tyr Gln Pro Tyr Leu Ile
            180                 185                 190         
Gln Pro Glu Asp Leu Arg Asp His Val Asn Asp Met Gly Phe Glu Ala
        195                 200                 205             
Ala Ile Lys Ser Lys Val Ala Pro Leu Ser Leu Gly Pro Ile Asp Ile
    210                 215                 220                 
Glu Arg Leu Gln Ser Thr Asn Pro Lys Arg Pro Leu Ser Ser Ala Asn
225                 230                 235                 240 
Gln Asn Phe Asn Asn Ser Glu Thr Leu Gly His Gln Gly Ser His Val
                245                 250                 255     
Val Thr Leu Gln Leu Arg Ile Asp Gly Met His Cys Lys Ser Cys Val
            260                 265                 270         
Leu Asn Ile Glu Glu Asn Ile Gly Gln Leu Leu Gly Val Gln Ser Ile
        275                 280                 285             
Gln Val Ser Leu Glu Asn Lys Thr Ala Gln Val Lys Tyr Asp Pro Ser
    290                 295                 300                 
Cys Thr Ser Pro Val Ala Leu Gln Arg Ala Ile Glu Ala Leu Pro Pro
305                 310                 315                 320 
Gly Asn Phe Lys Val Ser Leu Pro Asp Gly Ala Glu Gly Ser Gly Thr
                325                 330                 335     
Asp His Arg Ser Ser Ser Ser His Ser Pro Gly Ser Pro Pro Arg Asn
            340                 345                 350         
Gln Val Gln Gly Thr Cys Ser Thr Thr Leu Ile Ala Ile Ala Gly Met
        355                 360                 365             
Thr Cys Ala Ser Cys Val His Ser Ile Glu Gly Met Ile Ser Gln Leu
    370                 375                 380                 
Glu Gly Val Gln Gln Ile Ser Val Ser Leu Ala Glu Gly Thr Ala Thr
385                 390                 395                 400 
Val Leu Tyr Asn Pro Ser Val Ile Ser Pro Glu Glu Leu Arg Ala Ala
                405                 410                 415     
Ile Glu Asp Met Gly Phe Glu Ala Ser Val Val Ser Glu Ser Cys Ser
            420                 425                 430         
Thr Asn Pro Leu Gly Asn His Ser Ala Gly Asn Ser Met Val Gln Thr
        435                 440                 445             
Thr Asp Gly Thr Pro Thr Ser Val Gln Glu Val Ala Pro His Thr Gly
    450                 455                 460                 
Arg Leu Pro Ala Asn His Ala Pro Asp Ile Leu Ala Lys Ser Pro Gln
465                 470                 475                 480 
Ser Thr Arg Ala Val Ala Pro Gln Lys Cys Phe Leu Gln Ile Lys Gly
                485                 490                 495     
Met Thr Cys Ala Ser Cys Val Ser Asn Ile Glu Arg Asn Leu Gln Lys
            500                 505                 510         
Glu Ala Gly Val Leu Ser Val Leu Val Ala Leu Met Ala Gly Lys Ala
        515                 520                 525             
Glu Ile Lys Tyr Asp Pro Glu Val Ile Gln Pro Leu Glu Ile Ala Gln
    530                 535                 540                 
Phe Ile Gln Asp Leu Gly Phe Glu Ala Ala Val Met Glu Asp Tyr Ala
545                 550                 555                 560 
Gly Ser Asp Gly Asn Ile Glu Leu Thr Ile Thr Gly Met Thr Cys Ala
                565                 570                 575     
Ser Cys Val His Asn Ile Glu Ser Lys Leu Thr Arg Thr Asn Gly Ile
            580                 585                 590         
Thr Tyr Ala Ser Val Ala Leu Ala Thr Ser Lys Ala Leu Val Lys Phe
        595                 600                 605             
Asp Pro Glu Ile Ile Gly Pro Arg Asp Ile Ile Lys Ile Ile Glu Glu
    610                 615                 620                 
Ile Gly Phe His Ala Ser Leu Ala Gln Arg Asn Pro Asn Ala His His
625                 630                 635                 640 
Leu Asp His Lys Met Glu Ile Lys Gln Trp Lys Lys Ser Phe Leu Cys
                645                 650                 655     
Ser Leu Val Phe Gly Ile Pro Val Met Ala Leu Met Ile Tyr Met Leu
            660                 665                 670         
Ile Pro Ser Asn Glu Pro His Gln Ser Met Val Leu Asp His Asn Ile
        675                 680                 685             
Ile Pro Gly Leu Ser Ile Leu Asn Leu Ile Phe Phe Ile Leu Cys Thr
    690                 695                 700                 
Phe Val Gln Leu Leu Gly Gly Trp Tyr Phe Tyr Val Gln Ala Tyr Lys
705                 710                 715                 720 
Ser Leu Arg His Arg Ser Ala Asn Met Asp Val Leu Ile Val Leu Ala
                725                 730                 735     
Thr Ser Ile Ala Tyr Val Tyr Ser Leu Val Ile Leu Val Val Ala Val
            740                 745                 750         
Ala Glu Lys Ala Glu Arg Ser Pro Val Thr Phe Phe Asp Thr Pro Pro
        755                 760                 765             
Met Leu Phe Val Phe Ile Ala Leu Gly Arg Trp Leu Glu His Leu Ala
    770                 775                 780                 
Lys Ser Lys Thr Ser Glu Ala Leu Ala Lys Leu Met Ser Leu Gln Ala
785                 790                 795                 800 
Thr Glu Ala Thr Val Val Thr Leu Gly Glu Asp Asn Leu Ile Ile Arg
                805                 810                 815     
Glu Glu Gln Val Pro Met Glu Leu Val Gln Arg Gly Asp Ile Val Lys
            820                 825                 830         
Val Val Pro Gly Gly Lys Phe Pro Val Asp Gly Lys Val Leu Glu Gly
        835                 840                 845             
Asn Thr Met Ala Asp Glu Ser Leu Ile Thr Gly Glu Ala Met Pro Val
    850                 855                 860                 
Thr Lys Lys Pro Gly Ser Thr Val Ile Ala Gly Ser Ile Asn Ala His
865                 870                 875                 880 
Gly Ser Val Leu Ile Lys Ala Thr His Val Gly Asn Asp Thr Thr Leu
                885                 890                 895     
Ala Gln Ile Val Lys Leu Val Glu Glu Ala Gln Met Ser Lys Ala Pro
            900                 905                 910         
Ile Gln Gln Leu Ala Asp Arg Phe Ser Gly Tyr Phe Val Pro Phe Ile
        915                 920                 925             
Ile Ile Met Ser Thr Leu Thr Leu Val Val Trp Ile Val Ile Gly Phe
    930                 935                 940                 
Ile Asp Phe Gly Val Val Gln Arg Tyr Phe Pro Asn Pro Asn Lys His
945                 950                 955                 960 
Ile Ser Gln Thr Glu Val Ile Ile Arg Phe Ala Phe Gln Thr Ser Ile
                965                 970                 975     
Thr Val Leu Cys Ile Ala Cys Pro Cys Ser Leu Gly Leu Ala Thr Pro
            980                 985                 990         
Thr Ala Val Met Val Gly Thr Gly Val Ala Ala Gln Asn Gly Ile Leu
        995                 1000                1005            
Ile Lys Gly Gly Lys Pro Leu Glu Met Ala His Lys Ile Lys Thr Val
    1010                1015                1020                
Met Phe Asp Lys Thr Gly Thr Ile Thr His Gly Val Pro Arg Val Met
1025                1030                1035                1040
Arg Val Leu Leu Leu Gly Asp Val Ala Thr Leu Pro Leu Arg Lys Val
                1045                1050                1055    
Leu Ala Val Val Gly Thr Ala Glu Ala Ser Ser Glu His Pro Leu Gly
            1060                1065                1070        
Val Ala Val Thr Lys Tyr Cys Lys Glu Glu Leu Gly Thr Glu Thr Leu
        1075                1080                1085            
Gly Tyr Cys Thr Asp Phe Gln Ala Val Pro Gly Cys Gly Ile Gly Cys
    1090                1095                1100                
Lys Val Ser Asn Val Glu Gly Ile Leu Ala His Ser Glu Arg Pro Leu
1105                1110                1115                1120
Ser Ala Pro Ala Ser His Leu Asn Glu Ala Gly Ser Leu Pro Ala Glu
                1125                1130                1135    
Lys Asp Ala Val Pro Gln Thr Phe Ser Val Leu Ile Gly Asn Arg Glu
            1140                1145                1150        
Trp Leu Arg Arg Asn Gly Leu Thr Ile Ser Ser Asp Val Ser Asp Ala
        1155                1160                1165            
Met Thr Asp His Glu Met Lys Gly Gln Thr Ala Ile Leu Val Ala Ile
    1170                1175                1180                
Asp Gly Val Leu Cys Gly Met Ile Ala Ile Ala Asp Ala Val Lys Gln
1185                1190                1195                1200
Glu Ala Ala Leu Ala Val His Thr Leu Gln Ser Met Gly Val Asp Val
                1205                1210                1215    
Val Leu Ile Thr Gly Asp Asn Arg Lys Thr Ala Arg Ala Ile Ala Thr
            1220                1225                1230        
Gln Val Gly Ile Asn Lys Val Phe Ala Glu Val Leu Pro Ser His Lys
        1235                1240                1245            
Val Ala Lys Val Gln Glu Leu Gln Asn Lys Gly Lys Lys Val Ala Met
    1250                1255                1260                
Val Gly Asp Gly Val Asn Asp Ser Pro Ala Leu Ala Gln Ala Asp Met
1265                1270                1275                1280
Gly Val Ala Ile Gly Thr Gly Thr Asp Val Ala Ile Glu Ala Ala Asp
                1285                1290                1295    
Val Val Leu Ile Arg Met Ile Cys Trp Met Trp Trp Leu Ala Phe Thr
            1300                1305                1310        
Phe Pro Arg Gly Leu Ser Glu Gly Tyr Ala Ser Thr Trp Ser Trp His
        1315                1320                1325            


<210> 2125
<211> 1401
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 1248, 1249, 1250, 1251
<223> Xaa = Any Amino Acid

<400> 2125
Met Gln Glu Thr Gln Leu Cys Ser Thr Asp Ser Pro Leu Pro Leu Glu
 1               5                  10                  15      
Lys Glu Glu Gln Val Arg Leu Gln Ala Arg Lys Trp Leu Glu Glu Gln
            20                  25                  30          
Leu Lys Gln Tyr Arg Val Lys Arg Gln Gln Glu Arg Ser Ser Gln Pro
        35                  40                  45              
Ala Thr Lys Thr Arg Leu Phe Ser Thr Leu Asp Pro Glu Leu Met Leu
    50                  55                  60                  
Asn Pro Glu Asn Leu Pro Arg Ala Ser Thr Leu Ala Met Thr Lys Glu
65                  70                  75                  80  
Tyr Ser Phe Leu Arg Thr Ser Val Pro Arg Gly Pro Lys Val Gly Ser
                85                  90                  95      
Leu Gly Leu Pro Ala His Pro Arg Glu Lys Lys Thr Ser Lys Ser Ser
            100                 105                 110         
Lys Ile Arg Ser Leu Ala Asp Tyr Arg Thr Glu Asp Ser Asn Ala Gly
        115                 120                 125             
Asn Ser Gly Gly Asn Val Pro Ala Pro Asp Ser Thr Lys Gly Ser Leu
    130                 135                 140                 
Lys Gln Asn Arg Ser Ser Ala Ala Ser Val Val Ser Glu Ile Ser Leu
145                 150                 155                 160 
Ser Pro Asp Thr Asp Asp Arg Leu Glu Asn Thr Ser Leu Ala Gly Asp
                165                 170                 175     
Ser Val Ser Glu Val Asp Gly Asn Asp Ser Asp Ser Ser Ser Tyr Ser
            180                 185                 190         
Ser Ala Ser Thr Arg Gly Thr Tyr Gly Ile Leu Ser Lys Thr Val Gly
        195                 200                 205             
Thr Gln Asp Thr Pro Tyr Met Val Asn Gly Gln Glu Ile Pro Ala Asp
    210                 215                 220                 
Thr Leu Gly Gln Phe Pro Ser Ile Lys Asp Val Leu Gln Ala Ala Ala
225                 230                 235                 240 
Ala Glu His Gln Asp Gln Gly Gln Glu Val Asn Gly Glu Val Arg Ser
                245                 250                 255     
Arg Arg Asp Ser Ile Cys Ser Ser Val Ser Leu Glu Ser Ser Ala Ala
            260                 265                 270         
Glu Thr Gln Glu Glu Met Leu Gln Val Leu Lys Glu Lys Met Arg Leu
        275                 280                 285             
Glu Gly Gln Leu Glu Ala Leu Ser Leu Glu Ala Ser Gln Ala Leu Lys
    290                 295                 300                 
Glu Lys Ala Glu Leu Gln Ala Gln Leu Ala Ala Leu Ser Thr Lys Leu
305                 310                 315                 320 
Gln Ala Gln Val Glu Cys Ser His Ser Ser Gln Gln Arg Gln Asp Ser
                325                 330                 335     
Leu Ser Ser Glu Val Asp Thr Leu Lys Gln Ser Cys Trp Asp Leu Glu
            340                 345                 350         
Arg Ala Met Thr Asp Leu Gln Asn Met Leu Glu Ala Lys Asn Ala Ser
        355                 360                 365             
Leu Ala Ser Ser Asn Asn Asp Leu Gln Val Ala Glu Glu Gln Tyr Gln
    370                 375                 380                 
Arg Leu Met Ala Lys Val Glu Asp Met Gln Arg Ser Met Leu Ser Lys
385                 390                 395                 400 
Asp Asn Thr Val His Asp Leu Arg Gln Gln Met Thr Ala Leu Gln Ser
                405                 410                 415     
Gln Leu Gln Gln Val Gln Leu Glu Arg Thr Thr Leu Thr Ser Lys Leu
            420                 425                 430         
Lys Ala Ser Gln Ala Glu Ile Ser Ser Leu Gln Ser Val Arg Gln Trp
        435                 440                 445             
Tyr Gln Gln Gln Leu Ala Leu Ala Gln Glu Ala Arg Val Arg Leu Gln
    450                 455                 460                 
Gly Glu Met Ala His Ile Gln Val Gly Gln Met Thr Gln Ala Gly Leu
465                 470                 475                 480 
Leu Glu His Leu Lys Leu Glu Asn Val Ser Leu Ser Gln Gln Leu Thr
                485                 490                 495     
Glu Thr Gln His Arg Ser Met Lys Glu Lys Gly Arg Ile Ala Ala Gln
            500                 505                 510         
Leu Gln Gly Ile Glu Ala Asp Met Leu Asp Gln Glu Ala Ala Phe Met
        515                 520                 525             
Gln Ile Gln Glu Ala Lys Thr Met Val Glu Glu Asp Leu Gln Arg Arg
    530                 535                 540                 
Leu Glu Glu Phe Glu Gly Glu Arg Glu Arg Leu Gln Arg Met Ala Asp
545                 550                 555                 560 
Ser Ala Ala Ser Leu Glu Gln Gln Leu Glu Gln Val Lys Leu Thr Leu
                565                 570                 575     
Leu Gln Arg Asp Gln Gln Leu Glu Ala Leu Gln Gln Glu His Leu Asp
            580                 585                 590         
Leu Met Lys Gln Leu Thr Leu Thr Gln Glu Ala Leu Gln Ser Arg Glu
        595                 600                 605             
Gln Ser Leu Asp Ala Leu Gln Thr His Tyr Asp Glu Leu Gln Ala Arg
    610                 615                 620                 
Leu Gly Glu Leu Gln Gly Glu Ala Ala Ser Arg Glu Asp Thr Ile Cys
625                 630                 635                 640 
Leu Leu Gln Asn Glu Lys Ile Ile Leu Glu Ala Ala Leu Gln Ala Ala
                645                 650                 655     
Lys Ser Gly Lys Glu Glu Leu Asp Arg Gly Ala Arg Arg Leu Glu Glu
            660                 665                 670         
Gly Thr Glu Glu Thr Ser Glu Thr Leu Glu Lys Leu Arg Glu Glu Leu
        675                 680                 685             
Ala Ile Lys Ser Gly Gln Val Glu His Leu Gln Gln Glu Thr Ala Ala
    690                 695                 700                 
Leu Lys Lys Gln Met Gln Lys Ile Lys Glu Gln Phe Leu Gln Gln Lys
705                 710                 715                 720 
Val Met Val Glu Ala Tyr Arg Arg Asp Ala Thr Ser Lys Asp Gln Leu
                725                 730                 735     
Ile Ser Glu Leu Lys Ala Thr Arg Lys Arg Leu Asp Ser Glu Leu Lys
            740                 745                 750         
Glu Leu Arg Gln Glu Leu Met Gln Val His Gly Glu Lys Arg Thr Ala
        755                 760                 765             
Glu Ala Glu Leu Ser Arg Leu His Arg Glu Val Ala Gln Val Arg Gln
    770                 775                 780                 
His Met Ala Asp Leu Glu Gly His Leu Gln Ser Ala Gln Lys Glu Arg
785                 790                 795                 800 
Asp Glu Met Glu Thr His Leu Gln Ser Leu Gln Phe Asp Lys Glu Gln
                805                 810                 815     
Met Val Ala Val Thr Glu Ala Asn Glu Ala Leu Lys Lys Gln Ile Glu
            820                 825                 830         
Glu Leu Gln Gln Glu Ala Arg Lys Ala Ile Thr Glu Gln Lys Gln Lys
        835                 840                 845             
Met Arg Arg Leu Gly Ser Asp Leu Thr Ser Ala Gln Lys Glu Met Lys
    850                 855                 860                 
Thr Lys His Lys Ala Tyr Glu Asn Ala Val Gly Ile Leu Ser Arg Arg
865                 870                 875                 880 
Leu Gln Glu Ala Leu Ala Ala Lys Glu Ala Ala Asp Ala Glu Leu Gly
                885                 890                 895     
Gln Leu Arg Ala Gln Gly Gly Ser Ser Asp Ser Ser Leu Ala Leu His
            900                 905                 910         
Glu Arg Ile Gln Ala Leu Glu Ala Glu Leu Gln Ala Val Ser His Ser
        915                 920                 925             
Lys Thr Leu Leu Glu Lys Glu Leu Gln Glu Val Ile Ala Leu Thr Ser
    930                 935                 940                 
Gln Glu Leu Glu Glu Ser Arg Glu Lys Val Leu Glu Leu Glu Asp Glu
945                 950                 955                 960 
Leu Gln Glu Ser Arg Gly Phe Arg Lys Lys Ile Lys Arg Leu Glu Glu
                965                 970                 975     
Ser Asn Lys Lys Leu Ala Leu Glu Leu Glu His Glu Lys Gly Lys Leu
            980                 985                 990         
Thr Gly Leu Gly Gln Ser Asn Ala Ala Leu Arg Glu His Asn Ser Ile
        995                 1000                1005            
Leu Glu Thr Ala Leu Ala Lys Arg Glu Ala Asp Leu Val Gln Leu Asn
    1010                1015                1020                
Leu Gln Val Gln Ala Val Leu Gln Arg Lys Glu Glu Glu Asp Arg Gln
1025                1030                1035                1040
Met Lys His Leu Val Gln Ala Leu Gln Ala Ser Leu Glu Lys Glu Lys
                1045                1050                1055    
Glu Lys Val Asn Ser Leu Lys Glu Gln Val Ala Ala Ala Lys Val Glu
            1060                1065                1070        
Ala Gly His Asn Arg Arg His Phe Lys Ala Ala Ser Leu Glu Leu Ser
        1075                1080                1085            
Glu Val Lys Lys Glu Leu Gln Ala Lys Glu His Leu Val Gln Lys Leu
    1090                1095                1100                
Gln Ala Glu Ala Asp Asp Leu Gln Ile Arg Glu Gly Lys His Ser Gln
1105                1110                1115                1120
Glu Ile Ala Gln Phe Gln Ala Glu Leu Ala Glu Ala Arg Ala Gln Leu
                1125                1130                1135    
Gln Leu Leu Gln Lys Gln Leu Asp Glu Gln Leu Ser Lys Gln Pro Val
            1140                1145                1150        
Gly Asn Gln Glu Met Glu Asn Leu Lys Trp Glu Val Asp Gln Lys Glu
        1155                1160                1165            
Arg Glu Ile Gln Ser Leu Lys Gln Gln Leu Asp Leu Thr Glu Gln Gln
    1170                1175                1180                
Gly Arg Lys Glu Leu Glu Gly Leu Gln Gln Leu Leu Gln Asn Val Lys
1185                1190                1195                1200
Ser Glu Leu Glu Met Ala Gln Glu Asp Leu Ser Met Thr Gln Lys Asp
                1205                1210                1215    
Lys Phe Met Leu Gln Ala Lys Val Ser Glu Leu Lys Asn Asn Met Lys
            1220                1225                1230        
Thr Leu Leu Gln Gln Asn Gln Gln Leu Lys Leu Asp Leu Arg Arg Xaa
        1235                1240                1245            
Xaa Xaa Xaa Lys Gly Ala Glu Arg Arg Gly Gln Leu Phe Gln Pro Cys
    1250                1255                1260                
His Ala His Gln Asp Pro Gly Leu Pro Ser Ser Arg Leu Ala Ala Gly
1265                1270                1275                1280
Gly Ala Ala Glu Thr Thr Ala Arg Arg Glu Gln Gly Ala Pro Gln Glu
                1285                1290                1295    
Pro Glu Gln Leu Pro Pro Ala Ala Gln Ala Gly Asp Gly Gln Pro Ala
            1300                1305                1310        
Ala Pro Asp Gly Gly Ala Arg Pro Asp Gly Ala Arg Val Ser Val Leu
        1315                1320                1325            
Val Asp Ala Ala Gly Ala Ser His Cys Gln Pro Cys Ala Pro Gly Gly
    1330                1335                1340                
Ser Arg Arg Pro Thr Arg Arg Pro Thr Glu Thr Gln Ser Glu Gln Gly
1345                1350                1355                1360
Phe Gln Arg Arg Ala Gly Arg Val Thr Ala Val Asp Ser Pro Pro Cys
                1365                1370                1375    
Ala Ala Ala Pro Glu Gly Ser Tyr Gln Cys Tyr Leu Phe Asp Cys Val
            1380                1385                1390        
Val Asp Val Phe Leu Arg His Glu Ile
        1395                1400    


<210> 2126
<211> 719
<212> PRT
<213> Homo sapiens

<400> 2126
Met Ser Val Asp Lys Ala Glu Leu Cys Gly Ser Leu Leu Thr Trp Leu
 1               5                  10                  15      
Gln Thr Phe His Val Pro Ser Pro Cys Ala Ser Pro Gln Asp Leu Ser
            20                  25                  30          
Ser Gly Leu Ala Val Ala Tyr Val Leu Asn Gln Ile Asp Pro Ser Trp
        35                  40                  45              
Phe Asn Glu Ala Trp Leu Gln Gly Ile Ser Glu Asp Pro Gly Pro Asn
    50                  55                  60                  
Trp Lys Leu Lys Val Ser Asn Leu Lys Met Val Leu Arg Ser Leu Val
65                  70                  75                  80  
Glu Tyr Ser Gln Asp Val Leu Ala His Pro Val Ser Glu Glu His Leu
                85                  90                  95      
Pro Asp Val Ser Leu Ile Gly Glu Phe Ser Asp Pro Ala Glu Leu Gly
            100                 105                 110         
Lys Leu Leu Gln Leu Val Leu Gly Cys Ala Ile Ser Cys Glu Lys Lys
        115                 120                 125             
Gln Asp His Ile Gln Arg Ile Met Thr Leu Glu Glu Ser Val Gln His
    130                 135                 140                 
Val Val Met Glu Ala Ile Gln Glu Leu Met Thr Lys Asp Thr Pro Asp
145                 150                 155                 160 
Ser Leu Ser Pro Glu Thr Tyr Gly Asn Phe Asp Ser Gln Ser Arg Arg
                165                 170                 175     
Tyr Tyr Phe Leu Ser Glu Glu Ala Glu Glu Gly Asp Glu Leu Gln Gln
            180                 185                 190         
Arg Cys Leu Asp Leu Glu Arg Gln Leu Met Leu Leu Ser Glu Glu Lys
        195                 200                 205             
Gln Ser Leu Ala Gln Glu Asn Ala Gly Leu Arg Glu Arg Met Gly Arg
    210                 215                 220                 
Pro Glu Gly Glu Gly Thr Pro Gly Leu Thr Ala Lys Lys Leu Leu Leu
225                 230                 235                 240 
Leu Gln Ser Gln Leu Glu Gln Leu Gln Glu Glu Asn Phe Arg Leu Glu
                245                 250                 255     
Ser Gly Arg Glu Asp Glu Arg Leu Arg Cys Ala Glu Leu Glu Arg Glu
            260                 265                 270         
Val Ala Glu Leu Gln His Arg Asn Gln Ala Leu Thr Ser Leu Ala Gln
        275                 280                 285             
Glu Ala Gln Ala Leu Lys Asp Glu Met Asp Glu Leu Arg Gln Ser Ser
    290                 295                 300                 
Glu Arg Ala Gly Gln Leu Glu Ala Thr Leu Thr Ser Cys Arg Arg Arg
305                 310                 315                 320 
Leu Gly Glu Leu Arg Glu Leu Arg Arg Gln Val Arg Gln Leu Glu Glu
                325                 330                 335     
Arg Asn Ala Gly His Ala Glu Arg Thr Arg Gln Leu Glu Asp Glu Leu
            340                 345                 350         
Arg Arg Ala Gly Ser Leu Arg Ala Gln Leu Glu Ala Gln Arg Arg Gln
        355                 360                 365             
Val Gln Glu Leu Gln Gly Gln Arg Gln Glu Glu Ala Met Lys Ala Glu
    370                 375                 380                 
Lys Trp Leu Phe Glu Cys Arg Asn Leu Glu Glu Lys Tyr Glu Ser Val
385                 390                 395                 400 
Thr Lys Glu Lys Glu Arg Leu Leu Ala Glu Arg Asp Ser Leu Arg Glu
                405                 410                 415     
Ala Asn Glu Glu Leu Arg Cys Ala Gln Leu Gln Pro Arg Gly Leu Thr
            420                 425                 430         
Gln Ala Asp Pro Ser Leu Asp Pro Thr Ser Thr Pro Val Asp Asn Leu
        435                 440                 445             
Ala Ala Glu Ile Leu Pro Ala Glu Leu Arg Glu Thr Leu Leu Arg Leu
    450                 455                 460                 
Gln Leu Glu Asn Lys Arg Leu Cys Arg Gln Glu Ala Ala Asp Arg Glu
465                 470                 475                 480 
Arg Gln Glu Glu Leu Gln Arg Gln Leu Glu Asp Ala Asn Arg Ala Arg
                485                 490                 495     
His Gly Leu Glu Thr Gln His Arg Leu Asn Gln Gln Gln Leu Ser Glu
            500                 505                 510         
Leu Arg Ala Gln Val Glu Asp Leu Gln Lys Ala Leu Gln Glu Gln Gly
        515                 520                 525             
Gly Lys Thr Glu Asp Val Ser Ser Ile Leu Leu Lys Arg Lys Leu Glu
    530                 535                 540                 
Glu His Leu Gln Lys Leu His Glu Ala Asp Leu Glu Leu Gln Arg Lys
545                 550                 555                 560 
Arg Glu Tyr Ile Glu Glu Leu Glu Pro Pro Thr Asp Ser Ser Thr Ala
                565                 570                 575     
Arg Arg Ile Glu Glu Leu Gln His Asn Leu Gln Lys Lys Asp Ala Asp
            580                 585                 590         
Leu Arg Ala Met Glu Glu Arg Tyr Arg Arg Tyr Val Asp Lys Ala Arg
        595                 600                 605             
Met Val Met Gln Thr Met Glu Pro Lys Gln Arg Pro Ala Ala Gly Ala
    610                 615                 620                 
Pro Pro Glu Leu His Ser Leu Arg Thr Gln Leu Arg Glu Arg Asp Val
625                 630                 635                 640 
Arg Ile Arg His Leu Glu Met Asp Phe Glu Lys Ser Arg Ser Gln Arg
                645                 650                 655     
Glu Gln Glu Glu Lys Leu Leu Ile Ser Ala Trp Tyr Asn Met Gly Met
            660                 665                 670         
Ala Leu Gln Gln Arg Ala Gly Glu Glu Arg Ala Pro Ala His Ala Gln
        675                 680                 685             
Ser Phe Leu Ala Gln Gln Arg Leu Ala Thr Asn Ser Arg Arg Gly Pro
    690                 695                 700                 
Leu Gly Arg Leu Ala Ser Leu Asn Leu Arg Pro Thr Asp Lys His
705                 710                 715                 


<210> 2127
<211> 1208
<212> PRT
<213> Homo sapiens

<400> 2127
Met Asp Leu His Met Met Asn Cys Glu Leu Leu Ala Thr Cys Ser Ala
 1               5                  10                  15      
Leu Gly Tyr Leu Glu Gly Asp Thr Tyr His Lys Glu Pro Asp Cys Leu
            20                  25                  30          
Glu Ser Val Lys Asp Leu Ile Arg Tyr Leu Arg His Glu Asp Glu Thr
        35                  40                  45              
Arg Asp Val Arg Gln Gln Leu Gly Ala Ala Gln Ile Leu Gln Ser Asp
    50                  55                  60                  
Leu Leu Pro Ile Leu Thr Gln His His Gln Asp Lys Pro Leu Phe Asp
65                  70                  75                  80  
Ala Val Ile Arg Leu Met Val Asn Leu Thr Gln Pro Ala Leu Leu Cys
                85                  90                  95      
Phe Gly Asn Leu Pro Lys Glu Pro Ser Phe Arg His His Phe Leu Gln
            100                 105                 110         
Val Leu Thr Tyr Leu Gln Ala Tyr Lys Glu Ala Phe Ala Ser Glu Lys
        115                 120                 125             
Ala Phe Gly Val Leu Ser Glu Thr Leu Tyr Glu Leu Leu Gln Leu Gly
    130                 135                 140                 
Trp Glu Glu Arg Gln Glu Glu Asp Asn Leu Leu Ile Glu Arg Ile Leu
145                 150                 155                 160 
Leu Leu Val Arg Asn Ile Leu His Val Pro Ala Asp Leu Asp Gln Glu
                165                 170                 175     
Lys Lys Ile Asp Asp Asp Ala Ser Ala His Asp Gln Leu Leu Trp Ala
            180                 185                 190         
Ile His Leu Ser Gly Leu Asp Asp Leu Leu Leu Phe Leu Ala Ser Ser
        195                 200                 205             
Ser Ala Glu Glu Gln Trp Ser Leu His Val Leu Glu Ile Val Ser Leu
    210                 215                 220                 
Met Phe Arg Asp Gln Asn Pro Glu Gln Leu Ala Gly Val Gly Gln Gly
225                 230                 235                 240 
Arg Leu Ala Gln Glu Arg Ser Ala Asp Phe Ala Glu Leu Glu Val Leu
                245                 250                 255     
Arg Gln Arg Glu Met Ala Glu Lys Lys Thr Arg Ala Leu Gln Arg Gly
            260                 265                 270         
Asn Arg His Ser Arg Phe Gly Gly Ser Tyr Ile Val Gln Gly Leu Lys
        275                 280                 285             
Ser Ile Gly Glu Arg Asp Leu Ile Phe His Lys Gly Leu His Asn Leu
    290                 295                 300                 
Arg Asn Tyr Ser Ser Asp Leu Gly Lys Gln Pro Lys Lys Val Pro Lys
305                 310                 315                 320 
Arg Arg Gln Ala Ala Arg Glu Leu Ser Ile Gln Arg Arg Ser Ala Leu
                325                 330                 335     
Asn Val Arg Leu Phe Leu Arg Asp Phe Cys Ser Glu Phe Leu Glu Asn
            340                 345                 350         
Cys Tyr Asn Arg Leu Met Gly Ser Val Lys Asp His Leu Leu Arg Glu
        355                 360                 365             
Lys Ala Gln Gln His Asp Glu Thr Tyr Tyr Met Trp Ala Leu Ala Phe
    370                 375                 380                 
Phe Met Ala Phe Asn Arg Ala Ala Ser Phe Arg Pro Gly Leu Val Ser
385                 390                 395                 400 
Glu Thr Leu Ser Val Arg Thr Phe His Phe Ile Glu Gln Asn Leu Thr
                405                 410                 415     
Asn Tyr Tyr Glu Met Met Leu Thr Asp Arg Lys Glu Ala Ala Ser Trp
            420                 425                 430         
Ala Arg Arg Met His Leu Ala Leu Lys Ala Tyr Gln Glu Leu Leu Ala
        435                 440                 445             
Thr Val Asn Glu Met Asp Leu Ser Pro Asp Glu Ala Val Arg Glu Ser
    450                 455                 460                 
Ser Arg Ile Ile Lys Asn Asn Ile Phe Tyr Val Met Glu Tyr Arg Glu
465                 470                 475                 480 
Leu Phe Leu Ala Leu Phe Arg Lys Phe Asp Glu Arg Cys Gln Pro Arg
                485                 490                 495     
Ser Phe Leu Arg Asp Leu Val Glu Thr Thr His Leu Phe Leu Lys Met
            500                 505                 510         
Leu Glu Arg Phe Cys Arg Ser Arg Gly Asn Leu Val Val Gln Asn Lys
        515                 520                 525             
Gln Lys Lys Arg Arg Lys Lys Lys Lys Lys Val Leu Asp Gln Ala Ile
    530                 535                 540                 
Val Ser Gly Asn Val Pro Ser Ser Pro Glu Glu Val Glu Ala Val Trp
545                 550                 555                 560 
Pro Ala Leu Ala Glu Gln Leu Gln Cys Cys Ala Gln Asn Ser Glu Leu
                565                 570                 575     
Ser Met Asp Ser Val Val Pro Phe Asp Ala Ala Ser Glu Val Pro Val
            580                 585                 590         
Glu Glu Gln Arg Ala Glu Ala Met Val Arg Ile Gln Asp Cys Leu Leu
        595                 600                 605             
Ala Gly Gln Ala Pro Gln Ala Leu Thr Leu Leu Arg Ser Ala Arg Glu
    610                 615                 620                 
Val Trp Pro Glu Gly Asp Val Phe Gly Ser Gln Asp Ile Ser Pro Glu
625                 630                 635                 640 
Glu Glu Ile Gln Leu Leu Lys Gln Ile Leu Ser Ala Pro Leu Pro Arg
                645                 650                 655     
Gln Gln Gly Pro Glu Glu Arg Gly Ala Glu Glu Glu Glu Glu Glu Glu
            660                 665                 670         
Glu Glu Glu Glu Glu Glu Leu Gln Val Val Gln Val Ser Glu Lys Glu
        675                 680                 685             
Phe Asn Phe Leu Asp Tyr Leu Lys Arg Phe Ala Cys Ser Thr Val Val
    690                 695                 700                 
Arg Ala Tyr Val Leu Leu Leu Arg Ser Tyr Gln Gln Asn Ser Ala His
705                 710                 715                 720 
Thr Asn His Cys Ile Val Lys Met Leu His Arg Leu Ala His Asp Leu
                725                 730                 735     
Lys Met Glu Ala Leu Leu Phe Gln Leu Ser Val Phe Cys Leu Phe Asn
            740                 745                 750         
Arg Leu Leu Ser Asp Pro Ala Ala Gly Ala Tyr Lys Glu Leu Val Thr
        755                 760                 765             
Phe Ala Lys Tyr Ile Leu Gly Lys Phe Phe Ala Leu Ala Ala Val Asn
    770                 775                 780                 
Gln Lys Ala Phe Val Glu Leu Leu Phe Trp Lys Asn Thr Ala Val Val
785                 790                 795                 800 
Arg Glu Met Thr Glu Gly Tyr Gly Ser Leu Asp Asp Arg Ser Ser Ser
                805                 810                 815     
Arg Arg Ala Pro Thr Trp Ser Pro Glu Glu Glu Ala His Leu Gln Glu
            820                 825                 830         
Leu Tyr Leu Ala Asn Lys Asp Val Glu Gly Gln Asp Val Val Glu Ala
        835                 840                 845             
Ile Leu Ala His Leu Asn Thr Val Pro Arg Thr Arg Lys Gln Ile Ile
    850                 855                 860                 
His His Leu Val Gln Met Gly Leu Ala Asp Ser Val Lys Asp Phe Gln
865                 870                 875                 880 
Arg Lys Gly Thr His Ile Val Leu Trp Thr Gly Asp Gln Glu Leu Glu
                885                 890                 895     
Leu Gln Arg Leu Phe Glu Glu Phe Arg Asp Ser Asp Asp Val Leu Gly
            900                 905                 910         
His Ile Met Lys Asn Ile Thr Ala Lys Arg Ser Arg Ala Arg Ile Val
        915                 920                 925             
Asp Lys Leu Leu Ala Leu Gly Leu Val Ala Glu Arg Arg Glu Leu Tyr
    930                 935                 940                 
Lys Lys Arg Gln Lys Lys Leu Ala Ser Ser Ile Leu Pro Asn Gly Ala
945                 950                 955                 960 
Glu Ser Leu Lys Asp Phe Cys Gln Glu Asp Leu Glu Glu Glu Glu Asn
                965                 970                 975     
Leu Pro Glu Glu Asp Ser Glu Glu Glu Glu Glu Gly Gly Ser Glu Ala
            980                 985                 990         
Glu Gln Val Gln Gly Ser Leu Val Leu Ser Asn Glu Asn Leu Gly Gln
        995                 1000                1005            
Ser Leu His Gln Glu Gly Phe Ser Ile Pro Leu Leu Trp Leu Gln Asn
    1010                1015                1020                
Cys Leu Ile Arg Ala Ala Asp Asp Arg Gln Glu Asp Gly Cys Ser Gln
1025                1030                1035                1040
Ala Val Pro Leu Lys Pro Leu Pro Glu Glu Asn Glu Glu Ala Met Glu
                1045                1050                1055    
Asn Glu Gln Phe Gln Gln Leu Leu Arg Lys Leu Gly Val Arg Pro Pro
            1060                1065                1070        
Ala Ser Gly Gln Glu Thr Phe Trp Arg Ile Pro Ala Lys Leu Ser Pro
        1075                1080                1085            
Thr Gln Leu Arg Arg Ala Ala Ala Ser Leu Ser Gln Pro Glu Glu Glu
    1090                1095                1100                
Gln Lys Leu Gln Pro Glu Leu Gln Pro Lys Val Pro Gly Glu Gln Gly
1105                1110                1115                1120
Ser Asp Glu Glu His Cys Lys Glu His Arg Ala Gln Ala Leu Arg Ala
                1125                1130                1135    
Leu Leu Leu Ala His Lys Lys Lys Ala Gly Leu Ala Ser Pro Glu Glu
            1140                1145                1150        
Glu Asp Ala Val Gly Lys Glu Pro Leu Lys Ala Ala Pro Lys Lys Arg
        1155                1160                1165            
Gln Leu Leu Asp Ser Asp Glu Glu Gln Glu Glu Asp Glu Gly Arg Asn
    1170                1175                1180                
Arg Ala Pro Glu Leu Gly Ala Pro Gly Ile Gln Lys Lys Lys Arg Tyr
1185                1190                1195                1200
Gln Ile Glu Asp Asp Glu Asp Asp
                1205            


<210> 2128
<211> 353
<212> PRT
<213> Homo sapiens

<400> 2128
Met Leu Gln Leu Phe Ile Gly Thr Ala Asp Asp Arg Leu Leu Arg Pro
 1               5                  10                  15      
His Ala Phe Tyr Gln Val His Arg Ile Thr Gly Lys Thr Val Ser Thr
            20                  25                  30          
Thr Ser His Glu Ala Ile Leu Ser Asn Thr Lys Val Leu Glu Ile Pro
        35                  40                  45              
Leu Leu Pro Glu Asn Ser Met Arg Ala Val Ile Asp Cys Ala Gly Ile
    50                  55                  60                  
Leu Lys Leu Arg Asn Ser Asp Ile Glu Leu Arg Lys Gly Glu Thr Asp
65                  70                  75                  80  
Ile Gly Arg Lys Asn Thr Arg Val Arg Leu Val Phe Arg Val His Val
                85                  90                  95      
Pro Gln Pro Ser Gly Arg Thr Leu Ser Leu Gln Val Ala Ser Asn Pro
            100                 105                 110         
Ile Glu Cys Ser Gln Arg Ser Ala Gln Glu Leu Pro Leu Val Glu Lys
        115                 120                 125             
Gln Ser Thr Asp Ser Tyr Pro Val Val Gly Gly Lys Lys Met Val Leu
    130                 135                 140                 
Ser Gly His Asn Phe Leu Gln Asp Ser Lys Val Ile Phe Val Glu Lys
145                 150                 155                 160 
Ala Pro Asp Gly His His Val Trp Glu Met Glu Ala Lys Thr Asp Arg
                165                 170                 175     
Asp Leu Cys Lys Pro Asn Ser Leu Val Val Glu Ile Pro Pro Phe Arg
            180                 185                 190         
Asn Gln Arg Ile Thr Ser Pro Val His Val Ser Phe Tyr Val Cys Asn
        195                 200                 205             
Gly Lys Arg Lys Arg Ser Gln Tyr Gln Arg Phe Thr Tyr Leu Pro Ala
    210                 215                 220                 
Asn Val Pro Ile Ile Lys Thr Glu Pro Thr Asp Asp Tyr Glu Pro Ala
225                 230                 235                 240 
Pro Thr Cys Gly Pro Val Ser Gln Gly Leu Ser Pro Leu Pro Arg Pro
                245                 250                 255     
Tyr Tyr Ser Gln Gln Leu Ala Met Pro Pro Asp Pro Ser Ser Cys Leu
            260                 265                 270         
Val Ala Gly Phe Pro Pro Gly Pro Gln Arg Ser Thr Leu Met Pro Ala
        275                 280                 285             
Ala Pro Gly Val Ser Pro Lys Leu His Asp Leu Ser Pro Ala Ala Tyr
    290                 295                 300                 
Thr Lys Gly Val Ala Ser Pro Gly His Cys His Leu Gly Leu Pro Gln
305                 310                 315                 320 
Pro Ala Gly Glu Ala Pro Ala Val Gln Asp Val Pro Arg Pro Val Ala
                325                 330                 335     
Thr His Pro Gly Ser Pro Gly Gln Pro Pro Pro Ala Leu Leu Pro Gln
            340                 345                 350         
Gln
    


<210> 2129
<211> 431
<212> PRT
<213> Homo sapiens

<400> 2129
Met Ser Trp Val Gln Ala Thr Leu Leu Ala Arg Gly Leu Cys Arg Ala
 1               5                  10                  15      
Trp Gly Gly Thr Cys Gly Ala Ala Leu Thr Gly Thr Ser Ile Ser Gln
            20                  25                  30          
Val Pro Arg Arg Leu Pro Arg Gly Leu His Cys Ser Ala Ala Ala His
        35                  40                  45              
Ser Ser Glu Gln Ser Leu Val Pro Ser Pro Pro Glu Pro Arg Gln Arg
    50                  55                  60                  
Pro Thr Lys Ala Leu Val Pro Phe Glu Asp Leu Phe Gly Gln Ala Pro
65                  70                  75                  80  
Gly Gly Glu Arg Asp Lys Ala Ser Phe Leu Gln Thr Val Gln Lys Phe
                85                  90                  95      
Ala Glu His Ser Val Arg Lys Arg Gly His Ile Asp Phe Ile Tyr Leu
            100                 105                 110         
Ala Leu Arg Lys Met Arg Glu Tyr Gly Val Glu Arg Asp Leu Ala Val
        115                 120                 125             
Tyr Asn Gln Leu Leu Asn Ile Phe Pro Lys Glu Val Phe Arg Pro Arg
    130                 135                 140                 
Asn Ile Ile Gln Arg Ile Phe Val His Tyr Pro Arg Gln Gln Glu Cys
145                 150                 155                 160 
Gly Ile Ala Val Leu Glu Gln Met Glu Asn His Gly Val Met Pro Asn
                165                 170                 175     
Lys Glu Thr Glu Phe Leu Leu Ile Gln Ile Phe Gly Arg Lys Ser Tyr
            180                 185                 190         
Pro Met Leu Lys Leu Val Arg Leu Lys Leu Trp Phe Pro Arg Phe Met
        195                 200                 205             
Asn Val Asn Pro Phe Pro Val Pro Arg Asp Leu Pro Gln Asp Pro Val
    210                 215                 220                 
Glu Leu Ala Met Phe Gly Leu Arg His Met Glu Pro Asp Leu Ser Ala
225                 230                 235                 240 
Arg Val Thr Ile Tyr Gln Val Pro Leu Pro Lys Asp Ser Thr Gly Ala
                245                 250                 255     
Ala Asp Pro Pro Gln Pro His Ile Val Gly Ile Gln Ser Pro Asp Gln
            260                 265                 270         
Gln Ala Ala Leu Ala Arg His Asn Pro Ala Arg Pro Val Phe Val Glu
        275                 280                 285             
Gly Pro Phe Ser Leu Trp Leu Arg Asn Lys Cys Val Tyr Tyr His Ile
    290                 295                 300                 
Leu Arg Ala Asp Leu Leu Pro Pro Glu Glu Arg Glu Val Glu Glu Thr
305                 310                 315                 320 
Pro Glu Glu Trp Asn Leu Tyr Tyr Pro Met Gln Leu Asp Leu Glu Tyr
                325                 330                 335     
Val Arg Ser Gly Trp Asp Asn Tyr Glu Phe Asp Ile Asn Glu Val Glu
            340                 345                 350         
Glu Gly Pro Val Phe Ala Met Cys Met Ala Gly Ala His Asp Gln Ala
        355                 360                 365             
Thr Met Ala Lys Trp Ile Gln Gly Leu Gln Glu Thr Asn Pro Thr Leu
    370                 375                 380                 
Ala Gln Ile Pro Val Val Phe Arg Leu Ala Gly Ser Thr Arg Glu Leu
385                 390                 395                 400 
Gln Thr Ser Ser Ala Gly Leu Glu Glu Pro Pro Leu Pro Glu Asp His
                405                 410                 415     
Gln Glu Glu Asp Asp Asn Leu Gln Arg Gln Gln Gln Gly Gln Ser
            420                 425                 430     


<210> 2130
<211> 2701
<212> PRT
<213> Homo sapiens

<400> 2130
Met Thr Glu Lys Met Ser Ser Phe Leu Tyr Ile Gly Asp Ile Val Ser
 1               5                  10                  15      
Leu Tyr Ala Glu Gly Ser Val Asn Gly Phe Ile Ser Thr Leu Gly Leu
            20                  25                  30          
Val Asp Asp Arg Cys Val Val His Pro Glu Ala Gly Asp Leu Ala Asn
        35                  40                  45              
Pro Pro Lys Lys Phe Arg Asp Cys Leu Phe Lys Val Cys Pro Met Asn
    50                  55                  60                  
Arg Tyr Ser Ala Gln Lys Gln Tyr Trp Lys Ala Lys Gln Ala Lys Gln
65                  70                  75                  80  
Gly Asn His Thr Glu Ala Ala Leu Leu Lys Lys Leu Gln His Ala Ala
                85                  90                  95      
Glu Leu Glu Gln Lys Gln Asn Glu Ser Glu Asn Lys Lys Leu Leu Gly
            100                 105                 110         
Glu Ile Val Lys Tyr Ser Asn Val Ile Gln Leu Leu His Ile Lys Ser
        115                 120                 125             
Asn Lys Tyr Leu Thr Val Asn Lys Arg Leu Pro Ala Leu Leu Glu Lys
    130                 135                 140                 
Asn Ala Met Arg Val Ser Leu Asp Ala Ala Gly Asn Glu Gly Ser Trp
145                 150                 155                 160 
Phe Tyr Ile His Pro Phe Trp Lys Leu Arg Ser Glu Gly Asp Asn Ile
                165                 170                 175     
Val Val Gly Asp Lys Val Val Leu Met Pro Val Asn Ala Gly Gln Pro
            180                 185                 190         
Leu His Ala Ser Asn Ile Glu Leu Leu Asp Asn Pro Gly Cys Lys Glu
        195                 200                 205             
Val Asn Ala Val Asn Cys Asn Thr Ser Trp Lys Ile Thr Leu Phe Met
    210                 215                 220                 
Lys Tyr Ser Ser Tyr Arg Glu Asp Val Leu Lys Gly Gly Asp Val Val
225                 230                 235                 240 
Arg Leu Phe His Ala Glu Gln Glu Lys Phe Leu Thr Cys Asp Glu Tyr
                245                 250                 255     
Glu Lys Lys Gln His Ile Phe Leu Arg Thr Thr Leu Arg Gln Ser Ala
            260                 265                 270         
Thr Ser Ala Thr Ser Ser Lys Ala Leu Trp Glu Ile Glu Val Val His
        275                 280                 285             
His Asp Pro Cys Arg Gly Gly Ala Gly Gln Trp Asn Ser Leu Phe Arg
    290                 295                 300                 
Phe Lys His Leu Ala Thr Gly Asn Tyr Leu Ala Ala Glu Leu Asn Pro
305                 310                 315                 320 
Asp Tyr Arg Asp Ala Gln Asn Glu Gly Lys Asn Val Arg Asp Gly Val
                325                 330                 335     
Pro Pro Thr Ser Lys Lys Lys Arg Gln Ala Gly Glu Lys Ile Met Tyr
            340                 345                 350         
Thr Leu Val Ser Val Pro His Gly Asn Asp Ile Ala Ser Leu Phe Glu
        355                 360                 365             
Leu Asp Ala Thr Thr Leu Gln Arg Ala Asp Cys Leu Val Pro Arg Asn
    370                 375                 380                 
Ser Tyr Val Arg Leu Arg His Leu Cys Thr Asn Thr Trp Val Thr Ser
385                 390                 395                 400 
Thr Ser Ile Pro Ile Asp Thr Asp Glu Glu Arg Pro Val Met Leu Lys
                405                 410                 415     
Ile Gly Thr Cys Gln Thr Lys Glu Asp Lys Glu Ala Phe Ala Ile Val
            420                 425                 430         
Ser Val Pro Leu Ser Glu Val Arg Asp Leu Asp Phe Ala Asn Asp Ala
        435                 440                 445             
Asn Lys Val Leu Ala Thr Thr Val Lys Lys Leu Glu Asn Gly Thr Ile
    450                 455                 460                 
Thr Gln Asn Glu Arg Arg Phe Val Thr Lys Leu Leu Glu Asp Leu Ile
465                 470                 475                 480 
Phe Phe Val Ala Asp Val Pro Asn Asn Gly Gln Glu Val Leu Asp Val
                485                 490                 495     
Val Ile Thr Lys Pro Asn Arg Glu Arg Gln Lys Leu Met Arg Glu Gln
            500                 505                 510         
Asn Ile Leu Ala Gln Val Phe Gly Ile Leu Lys Ala Pro Phe Lys Glu
        515                 520                 525             
Lys Ala Gly Glu Gly Ser Met Leu Arg Leu Glu Asp Leu Gly Asp Gln
    530                 535                 540                 
Arg Tyr Ala Pro Tyr Lys Tyr Met Leu Arg Leu Cys Tyr Arg Val Leu
545                 550                 555                 560 
Arg His Ser Gln Gln Asp Tyr Arg Lys Asn Gln Glu Tyr Ile Ala Lys
                565                 570                 575     
Asn Phe Cys Val Met Gln Ser Gln Ile Gly Tyr Asp Ile Leu Ala Glu
            580                 585                 590         
Asp Thr Ile Thr Ala Leu Leu His Asn Asn Arg Lys Leu Leu Glu Lys
        595                 600                 605             
His Ile Thr Ala Lys Glu Ile Glu Thr Phe Val Ser Leu Leu Arg Arg
    610                 615                 620                 
Asn Arg Glu Pro Arg Phe Leu Asp Tyr Leu Ser Asp Leu Cys Val Ser
625                 630                 635                 640 
Asn Thr Thr Ala Ile Pro Val Thr Gln Glu Leu Ile Cys Lys Phe Met
                645                 650                 655     
Leu Ser Pro Gly Asn Ala Asp Ile Leu Ile Gln Thr Lys Val Val Ser
            660                 665                 670         
Met Gln Ala Asp Asn Pro Met Glu Ser Ser Ile Leu Ser Asp Asp Ile
        675                 680                 685             
Asp Asp Glu Glu Val Trp Leu Tyr Trp Ile Asp Ser Asn Lys Glu Pro
    690                 695                 700                 
His Gly Lys Ala Ile Arg His Leu Ala Gln Glu Ala Lys Glu Gly Thr
705                 710                 715                 720 
Lys Ala Asp Leu Glu Val Leu Thr Tyr Tyr Arg Tyr Gln Leu Asn Leu
                725                 730                 735     
Phe Ala Arg Met Cys Leu Asp Arg Gln Tyr Leu Ala Ile Asn Gln Ile
            740                 745                 750         
Ser Thr Gln Leu Ser Val Asp Leu Ile Leu Arg Cys Val Ser Asp Glu
        755                 760                 765             
Ser Leu Pro Phe Asp Leu Arg Ala Ser Phe Cys Arg Leu Met Leu His
    770                 775                 780                 
Met His Val Asp Arg Asp Pro Gln Glu Ser Val Val Pro Val Arg Tyr
785                 790                 795                 800 
Ala Arg Leu Trp Thr Glu Ile Pro Thr Lys Ile Thr Ile His Glu Tyr
                805                 810                 815     
Asp Ser Ile Thr Asp Ser Ser Arg Asn Asp Met Lys Arg Lys Phe Ala
            820                 825                 830         
Leu Thr Met Glu Phe Val Glu Glu Tyr Leu Lys Glu Val Val Asn Gln
        835                 840                 845             
Pro Phe Pro Phe Gly Asp Lys Glu Lys Asn Lys Leu Thr Phe Glu Val
    850                 855                 860                 
Val His Leu Ala Arg Asn Leu Ile Tyr Phe Gly Phe Tyr Ser Phe Ser
865                 870                 875                 880 
Glu Leu Leu Arg Leu Thr Arg Thr Leu Leu Ala Ile Leu Asp Ile Val
                885                 890                 895     
Gln Ala Pro Met Ser Ser Tyr Phe Glu Arg Leu Ser Lys Phe Gln Asp
            900                 905                 910         
Gly Gly Asn Asn Val Met Arg Thr Ile His Gly Val Gly Glu Met Met
        915                 920                 925             
Thr Gln Met Val Leu Ser Arg Gly Ser Ile Phe Pro Met Ser Val Pro
    930                 935                 940                 
Asp Val Pro Pro Ser Ile His Pro Ser Lys Gln Gly Ser Pro Thr Glu
945                 950                 955                 960 
His Glu Asp Val Thr Val Met Asp Thr Lys Leu Lys Ile Ile Glu Ile
                965                 970                 975     
Leu Gln Phe Ile Leu Ser Val Arg Leu Asp Tyr Arg Ile Ser Tyr Met
            980                 985                 990         
Leu Ser Ile Tyr Lys Lys Glu Phe Gly Glu Asp Asn Asp Asn Ala Glu
        995                 1000                1005            
Thr Ser Ala Ser Gly Ser Pro Asp Thr Leu Leu Pro Ser Ala Ile Val
    1010                1015                1020                
Pro Asp Ile Asp Glu Ile Ala Ala Gln Ala Glu Thr Met Phe Ala Gly
1025                1030                1035                1040
Arg Lys Glu Lys Asn Pro Val Gln Leu Asp Asp Glu Gly Gly Arg Thr
                1045                1050                1055    
Phe Leu Arg Val Leu Ile His Leu Ile Met His Asp Tyr Pro Pro Leu
            1060                1065                1070        
Leu Ser Gly Ala Leu Gln Leu Leu Phe Lys His Phe Ser Gln Arg Ala
        1075                1080                1085            
Glu Val Leu Gln Ala Phe Lys Gln Val Gln Leu Leu Val Ser Asn Gln
    1090                1095                1100                
Asp Val Asp Asn Tyr Lys Gln Ile Lys Ala Asp Leu Asp Gln Leu Arg
1105                1110                1115                1120
Leu Thr Val Glu Lys Ser Glu Leu Trp Val Glu Lys Ser Ser Asn Tyr
                1125                1130                1135    
Glu Asn Gly Glu Ile Gly Glu Ser Gln Val Lys Gly Gly Glu Glu Pro
            1140                1145                1150        
Ile Glu Glu Ser Asn Ile Leu Ser Pro Val Gln Asp Gly Thr Lys Lys
        1155                1160                1165            
Pro Gln Ile Asp Ser Asn Lys Ser Asn Asn Tyr Arg Ile Val Lys Glu
    1170                1175                1180                
Ile Leu Ile Arg Leu Ser Lys Leu Cys Val Gln Asn Lys Lys Cys Arg
1185                1190                1195                1200
Asn Gln His Gln Arg Leu Leu Lys Asn Met Gly Ala His Ser Val Val
                1205                1210                1215    
Leu Asp Leu Leu Gln Ile Pro Tyr Glu Lys Asn Asp Glu Lys Met Asn
            1220                1225                1230        
Glu Val Met Asn Leu Ala His Thr Phe Leu Gln Asn Phe Cys Arg Gly
        1235                1240                1245            
Asn Pro Gln Asn Gln Val Leu Leu His Lys His Leu Asn Leu Phe Leu
    1250                1255                1260                
Thr Pro Gly Leu Leu Glu Ala Glu Thr Met Arg His Ile Phe Met Asn
1265                1270                1275                1280
Asn Tyr His Leu Cys Asn Glu Ile Ser Glu Arg Val Val Gln His Phe
                1285                1290                1295    
Val His Cys Ile Glu Thr His Gly Arg His Val Glu Tyr Leu Arg Phe
            1300                1305                1310        
Leu Gln Thr Ile Val Lys Ala Asp Gly Lys Tyr Val Lys Lys Cys Gln
        1315                1320                1325            
Asp Met Val Met Thr Glu Leu Ile Asn Gly Gly Glu Asp Val Leu Ile
    1330                1335                1340                
Phe Tyr Asn Asp Arg Ala Ser Phe Pro Ile Leu Leu His Met Met Cys
1345                1350                1355                1360
Ser Glu Arg Asp Arg Gly Asp Glu Ser Gly Pro Leu Ala Tyr His Ile
                1365                1370                1375    
Thr Leu Val Glu Leu Leu Ala Ala Cys Thr Glu Gly Lys Asn Val Tyr
            1380                1385                1390        
Thr Glu Ile Lys Cys Asn Ser Leu Leu Pro Leu Asp Asp Ile Val Arg
        1395                1400                1405            
Val Val Thr His Asp Asp Cys Ile Pro Glu Val Lys Ile Ala Tyr Val
    1410                1415                1420                
Asn Phe Val Asn His Cys Tyr Val Asp Thr Glu Val Glu Met Lys Glu
1425                1430                1435                1440
Ile Tyr Thr Ser Asn His Ile Trp Lys Leu Phe Glu Asn Phe Leu Val
                1445                1450                1455    
Asp Met Ala Arg Val Cys Asn Thr Thr Thr Asp Arg Lys His Ala Asp
            1460                1465                1470        
Ile Phe Leu Glu Lys Cys Val Thr Glu Ser Ile Met Asn Ile Val Ser
        1475                1480                1485            
Gly Phe Phe Asn Ser Pro Phe Ser Asp Asn Ser Thr Ser Leu Gln Thr
    1490                1495                1500                
His Gln Pro Val Phe Ile Gln Leu Leu Gln Ser Ala Phe Arg Ile Tyr
1505                1510                1515                1520
Asn Cys Thr Trp Pro Asn Pro Ala Gln Lys Ala Ser Val Glu Ser Cys
                1525                1530                1535    
Ile Arg Thr Leu Ala Glu Val Ala Lys Asn Arg Gly Ile Ala Ile Pro
            1540                1545                1550        
Val Asp Leu Asp Ser Gln Val Asn Thr Leu Phe Met Lys Ser His Ser
        1555                1560                1565            
Asn Met Val Gln Arg Ala Ala Met Gly Trp Arg Leu Ser Ala Arg Ser
    1570                1575                1580                
Gly Pro Arg Phe Lys Glu Ala Leu Gly Gly Pro Ala Trp Asp Tyr Arg
1585                1590                1595                1600
Asn Ile Ile Glu Lys Leu Gln Asp Val Val Ala Ser Leu Glu His Gln
                1605                1610                1615    
Phe Ser Pro Met Met Gln Ala Glu Phe Ser Val Leu Val Asp Val Leu
            1620                1625                1630        
Tyr Ser Pro Glu Leu Leu Phe Pro Glu Gly Ser Asp Ala Arg Ile Arg
        1635                1640                1645            
Cys Gly Ala Phe Met Ser Lys Leu Ile Asn His Thr Lys Lys Leu Met
    1650                1655                1660                
Glu Lys Glu Glu Lys Leu Cys Ile Lys Ile Leu Gln Thr Leu Arg Glu
1665                1670                1675                1680
Met Leu Glu Lys Lys Asp Ser Phe Val Glu Glu Gly Asn Thr Leu Arg
                1685                1690                1695    
Lys Ile Leu Leu Asn Arg Tyr Phe Lys Gly Asp Tyr Ser Ile Gly Val
            1700                1705                1710        
Asn Gly His Leu Ser Gly Ala Tyr Ser Lys Thr Ala Gln Val Gly Gly
        1715                1720                1725            
Ser Phe Ser Gly Gln Asp Ser Asp Lys Met Gly Ile Ser Met Ser Asp
    1730                1735                1740                
Ile Gln Cys Leu Leu Asp Lys Glu Gly Ala Ser Glu Leu Val Ile Asp
1745                1750                1755                1760
Val Ile Val Asn Thr Lys Asn Asp Arg Ile Phe Ser Glu Gly Ile Phe
                1765                1770                1775    
Leu Gly Ile Ala Leu Leu Glu Gly Gly Asn Thr Gln Thr Gln Tyr Ser
            1780                1785                1790        
Phe Tyr Gln Gln Leu His Glu Gln Lys Lys Ser Glu Lys Phe Phe Lys
        1795                1800                1805            
Val Leu Tyr Asp Arg Met Lys Ala Ala Gln Lys Glu Ile Arg Ser Thr
    1810                1815                1820                
Val Thr Val Asn Thr Ile Asp Leu Gly Asn Lys Lys Arg Asp Asp Asp
1825                1830                1835                1840
Asn Glu Leu Met Thr Ser Gly Pro Arg Met Arg Val Arg Asp Ser Thr
                1845                1850                1855    
Leu His Leu Lys Glu Gly Met Lys Gly Gln Leu Thr Glu Ala Ser Ser
            1860                1865                1870        
Ala Thr Ser Lys Ala Tyr Cys Val Tyr Arg Arg Glu Met Asp Pro Glu
        1875                1880                1885            
Ile Asp Ile Met Cys Thr Gly Pro Glu Ala Gly Asn Thr Glu Glu Lys
    1890                1895                1900                
Ser Ala Glu Glu Val Thr Met Ser Pro Ala Ile Ala Ile Met Gln Pro
1905                1910                1915                1920
Ile Leu Arg Phe Leu Gln Leu Leu Cys Glu Asn His Asn Arg Glu Leu
                1925                1930                1935    
Gln Asn Phe Leu Arg Asn Gln Asn Asn Lys Thr Asn Tyr Asn Leu Val
            1940                1945                1950        
Cys Glu Thr Leu Gln Phe Leu Asp Cys Ile Cys Gly Ser Thr Thr Gly
        1955                1960                1965            
Gly Leu Gly Leu Leu Gly Leu Tyr Ile Asn Glu Lys Asn Val Ala Leu
    1970                1975                1980                
Val Asn Gln Asn Leu Glu Ser Leu Thr Glu Tyr Cys Gln Gly Pro Cys
1985                1990                1995                2000
His Glu Asn Gln Thr Cys Ile Ala Thr His Glu Ser Asn Gly Ile Asp
                2005                2010                2015    
Ile Ile Ile Ala Leu Ile Leu Asn Asp Ile Asn Pro Leu Gly Lys Tyr
            2020                2025                2030        
Arg Met Asp Leu Val Leu Gln Leu Lys Asn Asn Ala Ser Lys Leu Leu
        2035                2040                2045            
Leu Ala Ile Met Glu Ser Arg His Asp Ser Glu Asn Ala Glu Arg Ile
    2050                2055                2060                
Leu Phe Asn Met Arg Pro Arg Glu Leu Val Asp Val Met Lys Asn Ala
2065                2070                2075                2080
Tyr Asn Gln Gly Leu Glu Cys Asp His Gly Asp Asp Glu Gly Gly Asp
                2085                2090                2095    
Asp Gly Val Ser Pro Lys Asp Val Gly His Asn Ile Tyr Ile Leu Ala
            2100                2105                2110        
His Gln Leu Ala Arg His Asn Lys Leu Leu Gln Gln Met Leu Lys Pro
        2115                2120                2125            
Gly Ser Asp Pro Asp Glu Gly Asp Glu Ala Leu Lys Tyr Tyr Ala Asn
    2130                2135                2140                
His Thr Ala Gln Ile Glu Ile Val Arg His Asp Arg Thr Met Glu Gln
2145                2150                2155                2160
Ile Val Phe Pro Val Pro Asn Ile Cys Glu Tyr Leu Thr Arg Glu Ser
                2165                2170                2175    
Lys Cys Arg Val Phe Asn Thr Thr Glu Arg Asp Glu Gln Gly Ser Lys
            2180                2185                2190        
Val Asn Asp Phe Phe Gln Gln Thr Glu Asp Leu Tyr Asn Glu Met Lys
        2195                2200                2205            
Trp Gln Lys Lys Ile Arg Asn Asn Pro Ala Leu Phe Trp Phe Ser Arg
    2210                2215                2220                
His Ile Ser Leu Trp Gly Ser Ile Ser Phe Asn Leu Ala Val Phe Ile
2225                2230                2235                2240
Asn Leu Ala Val Ala Leu Phe Tyr Pro Phe Gly Asp Asp Gly Asp Glu
                2245                2250                2255    
Gly Thr Leu Ser Pro Leu Phe Ser Val Leu Leu Trp Ile Ala Val Ala
            2260                2265                2270        
Ile Cys Thr Ser Met Leu Phe Phe Phe Ser Lys Pro Val Gly Ile Arg
        2275                2280                2285            
Pro Phe Leu Val Ser Ile Met Leu Arg Ser Ile Tyr Thr Ile Gly Leu
    2290                2295                2300                
Gly Pro Thr Leu Ile Leu Leu Gly Ala Ala Asn Leu Cys Asn Lys Ile
2305                2310                2315                2320
Val Phe Leu Val Ser Phe Val Gly Asn Arg Gly Thr Phe Thr Arg Gly
                2325                2330                2335    
Tyr Arg Ala Val Ile Leu Asp Met Ala Phe Leu Tyr His Val Ala Tyr
            2340                2345                2350        
Val Leu Val Cys Met Leu Gly Leu Phe Val His Glu Phe Phe Tyr Ser
        2355                2360                2365            
Phe Leu Leu Phe Asp Leu Val Tyr Arg Glu Glu Thr Leu Leu Asn Val
    2370                2375                2380                
Ile Lys Ser Val Thr Arg Asn Gly Arg Ser Ile Ile Leu Thr Ala Val
2385                2390                2395                2400
Leu Ala Leu Ile Leu Val Tyr Leu Phe Ser Ile Ile Gly Phe Leu Phe
                2405                2410                2415    
Leu Lys Asp Asp Phe Thr Met Glu Val Asp Arg Leu Lys Asn Arg Thr
            2420                2425                2430        
Pro Val Thr Gly Ser His Gln Val Pro Thr Met Thr Leu Thr Thr Met
        2435                2440                2445            
Met Glu Ala Cys Ala Lys Glu Asn Cys Ser Pro Thr Ile Pro Ala Ser
    2450                2455                2460                
Asn Thr Ala Asp Glu Glu Tyr Glu Asp Gly Ile Glu Arg Thr Cys Asp
2465                2470                2475                2480
Thr Leu Leu Met Cys Ile Val Thr Val Leu Asn Gln Gly Leu Arg Asn
                2485                2490                2495    
Gly Gly Gly Val Gly Asp Val Leu Arg Arg Pro Ser Lys Asp Glu Pro
            2500                2505                2510        
Leu Phe Ala Ala Arg Val Val Tyr Asp Leu Leu Phe Tyr Phe Ile Val
        2515                2520                2525            
Ile Ile Ile Val Leu Asn Leu Ile Phe Gly Val Ile Ile Asp Thr Phe
    2530                2535                2540                
Ala Asp Leu Arg Ser Glu Lys Gln Lys Lys Glu Glu Ile Leu Lys Thr
2545                2550                2555                2560
Thr Cys Phe Ile Cys Gly Leu Glu Arg Asp Lys Phe Asp Asn Lys Thr
                2565                2570                2575    
Val Ser Phe Glu Glu His Ile Lys Ser Glu His Asn Met Trp His Tyr
            2580                2585                2590        
Leu Tyr Phe Ile Val Leu Val Lys Val Lys Asp Pro Thr Glu Tyr Thr
        2595                2600                2605            
Gly Pro Glu Ser Tyr Val Ala Gln Met Ile Val Glu Lys Asn Leu Asp
    2610                2615                2620                
Trp Phe Pro Arg Met Arg Ala Met Ser Leu Val Ser Asn Glu Gly Asp
2625                2630                2635                2640
Ser Glu Gln Asn Glu Ile Arg Ser Leu Gln Glu Lys Leu Glu Ser Thr
                2645                2650                2655    
Met Ser Leu Val Lys Gln Leu Ser Gly Gln Leu Ala Glu Leu Lys Glu
            2660                2665                2670        
Gln Met Thr Glu Gln Arg Lys Asn Lys Gln Arg Leu Gly Phe Leu Gly
        2675                2680                2685            
Ser Asn Thr Pro His Val Asn His His Met Pro Pro His
    2690                2695                2700    


<210> 2131
<211> 205
<212> PRT
<213> Homo sapiens

<400> 2131
Met Phe Val Met Gly Val Asn His Glu Lys Tyr Asp Asn Asn Leu Lys
 1               5                  10                  15      
Ile Val Gly Ser Ala Phe Cys Thr Thr Asn Cys Leu Ala Pro Leu Ala
            20                  25                  30          
Lys Val Ile His Asp Asn Phe Gly Ile Val Glu Gly Leu Met Thr Ile
        35                  40                  45              
Val His Ala Ile Thr Ala Thr Gln Lys Thr Val Asp Gly Pro Ser Gly
    50                  55                  60                  
Lys Leu Trp Arg Asp Gly His Gly Ala Leu Gln Asn Ile Ile Pro Ala
65                  70                  75                  80  
Ser Thr Gly Thr Ala Lys Ala Met Gly Lys Val Ile Pro Glu Leu Asn
                85                  90                  95      
Gly Lys Leu Thr Gly Met Ala Phe Cys Val Pro Thr Ala Val Ser Val
            100                 105                 110         
Val Asp Leu Thr Cys Arg Leu Glu Lys Pro Ala Lys Tyr Asp Asp Thr
        115                 120                 125             
Lys Lys Val Val Lys Gln Ala Ser Glu Gly Pro Leu Lys Gly Ile Leu
    130                 135                 140                 
Gly Tyr Thr Glu His Gln Val Val Ser Ser Asp Phe Asn Ser Asn Thr
145                 150                 155                 160 
His Ser Ser Thr Phe Asn Ala Gly Ala Val Ile Ala Leu Asn Asn His
                165                 170                 175     
Phe Phe Lys Leu Ile Ser Trp Tyr Asp Asn Glu Phe Gly Tyr Ser Asn
            180                 185                 190         
Arg Met Val Asp Leu Met Ala His Met Ala Ser Lys Glu
        195                 200                 205 


<210> 2132
<211> 444
<212> PRT
<213> Homo sapiens

<400> 2132
Met Arg Glu Ile Val His Ile Gln Ala Gly Gln Cys Gly Asn Gln Ile
 1               5                  10                  15      
Gly Ala Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro
            20                  25                  30          
Thr Gly Thr Tyr His Gly Asp Ser Asp Leu Gln Leu Asp Arg Ile Ser
        35                  40                  45              
Val Tyr Tyr Asn Glu Ala Thr Gly Gly Lys Tyr Val Pro Arg Ala Ile
    50                  55                  60                  
Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Pro
65                  70                  75                  80  
Phe Gly Gln Ile Phe Arg Pro Asp Asn Phe Val Phe Gly Gln Ser Gly
                85                  90                  95      
Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu
            100                 105                 110         
Val Asp Ser Val Leu Asp Val Val Arg Lys Glu Ala Glu Ser Cys Asp
        115                 120                 125             
Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly
    130                 135                 140                 
Ser Gly Met Gly Thr Leu Leu Ile Ser Lys Ile Arg Glu Glu Tyr Pro
145                 150                 155                 160 
Asp Arg Ile Met Asn Thr Phe Ser Val Val Pro Ser Pro Lys Val Ser
                165                 170                 175     
Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Val His Gln Leu
            180                 185                 190         
Val Glu Asn Thr Asp Glu Thr Tyr Cys Ile Asp Asn Glu Ala Leu Tyr
        195                 200                 205             
Asp Ile Cys Phe Arg Thr Leu Lys Leu Thr Thr Pro Thr Tyr Gly Asp
    210                 215                 220                 
Leu Asn His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Cys Leu
225                 230                 235                 240 
Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn
                245                 250                 255     
Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro
            260                 265                 270         
Leu Thr Ser Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Pro Glu
        275                 280                 285             
Leu Thr Gln Gln Val Phe Asp Ala Lys Asn Met Met Ala Ala Cys Asp
    290                 295                 300                 
Pro Arg His Gly Arg Tyr Leu Thr Val Ala Ala Val Phe Arg Gly Arg
305                 310                 315                 320 
Met Ser Met Lys Glu Val Asp Glu Gln Met Leu Asn Val Gln Asn Lys
                325                 330                 335     
Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Thr Ala
            340                 345                 350         
Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ala Val Thr Phe Ile
        355                 360                 365             
Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln
    370                 375                 380                 
Phe Thr Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly
385                 390                 395                 400 
Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn
                405                 410                 415     
Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Glu Glu
            420                 425                 430         
Glu Glu Asp Phe Gly Glu Glu Ala Glu Glu Glu Ala
        435                 440                 


<210> 2133
<211> 609
<212> PRT
<213> Homo sapiens

<400> 2133
Met Phe Arg Cys Gly Gly Leu Ala Ala Gly Ala Leu Lys Gln Lys Leu
 1               5                  10                  15      
Val Pro Leu Val Arg Thr Val Cys Val Arg Ser Pro Arg Gln Arg Asn
            20                  25                  30          
Arg Leu Pro Val Val Gln Ser His His Leu Gly Ser Pro Ser Arg Ser
        35                  40                  45              
Leu Ala Ser Thr Gly Ala Ser Gly Lys Asp Gly Ser Asn Leu Val Tyr
    50                  55                  60                  
Phe Leu Ile Val Gly Ala Thr Val Thr Gly Ala Gly Val Tyr Tyr Ala
65                  70                  75                  80  
Tyr Lys Thr Met Lys Glu Asp Glu Lys Arg Tyr Asn Glu Arg Ile Ser
                85                  90                  95      
Gly Leu Gly Leu Thr Pro Glu Gln Lys Gln Lys Lys Ala Ala Leu Ser
            100                 105                 110         
Ala Ser Glu Gly Glu Glu Val Pro Gln Asp Lys Ala Pro Ser His Val
        115                 120                 125             
Pro Phe Leu Leu Ile Gly Gly Gly Thr Ala Ala Phe Ala Ala Ala Arg
    130                 135                 140                 
Ser Ile Arg Ala Arg Asp Pro Gly Ala Arg Val Leu Ile Val Ser Glu
145                 150                 155                 160 
Asp Pro Glu Leu Pro Tyr Met Arg Pro Pro Leu Ser Lys Glu Leu Trp
                165                 170                 175     
Phe Ser Asp Asp Pro Asn Val Thr Lys Thr Leu Arg Phe Lys Gln Trp
            180                 185                 190         
Asn Gly Lys Glu Arg Ser Ile Tyr Phe Gln Pro Pro Ser Phe Tyr Val
        195                 200                 205             
Ser Ala Gln Asp Leu Pro His Ile Glu Asn Gly Gly Val Ala Val Leu
    210                 215                 220                 
Thr Gly Lys Lys Val Val Gln Leu Asp Val Arg Asp Asn Met Val Lys
225                 230                 235                 240 
Leu Asn Asp Gly Ser Gln Ile Thr Tyr Glu Lys Cys Leu Ile Ala Thr
                245                 250                 255     
Gly Gly Thr Pro Arg Ser Leu Ser Ala Ile Asp Arg Ala Gly Ala Glu
            260                 265                 270         
Val Lys Ser Arg Thr Thr Leu Phe Arg Lys Ile Gly Asp Phe Arg Ser
        275                 280                 285             
Leu Glu Lys Ile Ser Arg Glu Val Lys Ser Ile Thr Ile Ile Gly Gly
    290                 295                 300                 
Gly Phe Leu Gly Ser Glu Leu Ala Cys Ala Leu Gly Arg Lys Ala Arg
305                 310                 315                 320 
Ala Leu Gly Thr Glu Val Ile Gln Leu Phe Pro Glu Lys Gly Asn Met
                325                 330                 335     
Gly Lys Ile Leu Pro Glu Tyr Leu Ser Asn Trp Thr Met Glu Lys Val
            340                 345                 350         
Arg Arg Glu Gly Val Lys Val Met Pro Asn Ala Ile Val Gln Ser Val
        355                 360                 365             
Gly Val Ser Ser Gly Lys Leu Leu Ile Lys Leu Lys Asp Gly Arg Lys
    370                 375                 380                 
Val Glu Thr Asp His Ile Val Ala Ala Val Gly Leu Glu Pro Asn Val
385                 390                 395                 400 
Glu Leu Ala Lys Thr Gly Gly Leu Glu Ile Asp Ser Asp Phe Gly Gly
                405                 410                 415     
Phe Arg Val Asn Ala Glu Leu Gln Ala Arg Ser Asn Ile Trp Val Ala
            420                 425                 430         
Gly Asp Ala Ala Cys Phe Tyr Asp Ile Lys Leu Gly Arg Arg Arg Val
        435                 440                 445             
Glu His His Asp His Ala Val Val Ser Gly Arg Leu Ala Gly Glu Asn
    450                 455                 460                 
Met Thr Gly Ala Ala Lys Pro Tyr Trp His Gln Ser Met Phe Trp Ser
465                 470                 475                 480 
Asp Leu Gly Pro Asp Val Gly Tyr Glu Ala Ile Gly Leu Val Asp Ser
                485                 490                 495     
Ser Leu Pro Thr Val Gly Val Phe Ala Lys Ala Thr Ala Gln Asp Asn
            500                 505                 510         
Pro Lys Ser Ala Thr Glu Gln Ser Gly Thr Gly Ile Arg Ser Glu Ser
        515                 520                 525             
Glu Thr Glu Ser Glu Ala Ser Glu Ile Thr Ile Pro Pro Ser Thr Pro
    530                 535                 540                 
Ala Val Pro Gln Ala Pro Val Gln Gly Glu Asp Tyr Gly Lys Gly Val
545                 550                 555                 560 
Ile Phe Tyr Leu Arg Asp Lys Val Val Val Gly Ile Val Leu Trp Asn
                565                 570                 575     
Ile Phe Asn Arg Met Pro Ile Ala Arg Lys Ile Ile Lys Asp Gly Glu
            580                 585                 590         
Gln His Glu Asp Leu Asn Glu Val Ala Lys Leu Phe Asn Ile His Glu
        595                 600                 605             
Asp
    


<210> 2134
<211> 271
<212> PRT
<213> Homo sapiens

<400> 2134
Met Arg Pro Val Val Leu Val Gly Pro Ser Leu Lys Gly Tyr Glu Val
 1               5                  10                  15      
Thr Asp Met Met Gln Lys Ala Leu Phe Asp Phe Leu Lys His Arg Phe
            20                  25                  30          
Asp Gly Arg Ile Ser Ile Thr Arg Val Thr Ala Asp Leu Ser Leu Ala
        35                  40                  45              
Lys Arg Ser Val Leu Asn Asn Pro Gly Lys Arg Thr Ile Ile Glu Arg
    50                  55                  60                  
Ser Ser Ala Arg Ser Ser Ile Ala Glu Val Gln Ser Glu Ile Glu Arg
65                  70                  75                  80  
Ile Phe Glu Leu Ala Lys Ser Leu Gln Leu Val Val Leu Asp Ala Asp
                85                  90                  95      
Thr Ile Asn His Pro Ala Gln Leu Ala Lys Thr Ser Leu Ala Pro Ile
            100                 105                 110         
Ile Val Phe Val Lys Val Ser Ser Pro Lys Val Leu Gln Arg Leu Ile
        115                 120                 125             
Arg Ser Arg Gly Lys Ser Gln Met Lys His Leu Thr Val Gln Met Met
    130                 135                 140                 
Ala Tyr Asp Lys Leu Val Gln Cys Pro Pro Glu Ser Phe Asp Val Ile
145                 150                 155                 160 
Leu Asp Glu Asn Gln Leu Glu Asp Ala Cys Glu His Leu Ala Glu Tyr
                165                 170                 175     
Leu Glu Val Tyr Trp Arg Ala Thr His His Pro Ala Pro Gly Pro Gly
            180                 185                 190         
Leu Leu Gly Pro Pro Ser Ala Ile Pro Gly Leu Gln Asn Gln Gln Leu
        195                 200                 205             
Leu Gly Glu Arg Gly Glu Glu His Ser Pro Leu Glu Arg Asp Ser Leu
    210                 215                 220                 
Met Pro Ser Asp Glu Ala Ser Glu Thr Pro Ala Lys Pro Gly Gln Asp
225                 230                 235                 240 
Leu His Ser Val Leu Pro Pro Pro Gly Gly Gly Leu Cys Arg Cys Leu
                245                 250                 255     
Pro Gly Pro Val Pro Ala Ser Pro Pro Thr His Leu Gly Ala Ala
            260                 265                 270     


<210> 2135
<211> 1997
<212> PRT
<213> Homo sapiens

<400> 2135
Met Leu Ser His Gly Ala Gly Leu Ala Leu Trp Ile Thr Leu Ser Leu
 1               5                  10                  15      
Leu Gln Thr Gly Leu Ala Glu Pro Glu Arg Cys Asn Phe Thr Leu Ala
            20                  25                  30          
Glu Ser Lys Ala Ser Ser His Ser Val Ser Ile Gln Trp Arg Ile Leu
        35                  40                  45              
Gly Ser Pro Cys Asn Phe Ser Leu Ile Tyr Ser Ser Asp Thr Leu Gly
    50                  55                  60                  
Ala Ala Leu Cys Pro Thr Phe Arg Ile Asp Asn Thr Thr Tyr Gly Cys
65                  70                  75                  80  
Asn Leu Gln Asp Leu Gln Ala Gly Thr Ile Tyr Asn Phe Arg Ile Ile
                85                  90                  95      
Ser Leu Asp Glu Glu Arg Thr Val Val Leu Gln Thr Asp Pro Leu Pro
            100                 105                 110         
Pro Ala Arg Phe Gly Val Ser Lys Glu Lys Thr Thr Ser Thr Ser Leu
        115                 120                 125             
His Val Trp Trp Thr Pro Ser Ser Gly Lys Val Thr Ser Tyr Glu Val
    130                 135                 140                 
Gln Leu Phe Asp Glu Asn Asn Gln Lys Ile Gln Gly Val Gln Ile Gln
145                 150                 155                 160 
Glu Ser Thr Ser Trp Asn Glu Tyr Thr Phe Phe Asn Leu Thr Ala Gly
                165                 170                 175     
Ser Lys Tyr Asn Ile Ala Ile Thr Ala Val Ser Gly Gly Lys Arg Ser
            180                 185                 190         
Phe Ser Val Tyr Thr Asn Gly Ser Thr Val Pro Ser Pro Val Lys Asp
        195                 200                 205             
Ile Gly Ile Ser Thr Lys Ala Asn Ser Leu Leu Ile Ser Trp Ser His
    210                 215                 220                 
Gly Ser Gly Asn Val Glu Arg Tyr Arg Leu Met Leu Met Asp Lys Gly
225                 230                 235                 240 
Ile Leu Val His Gly Gly Val Val Asp Lys His Ala Thr Ser Tyr Ala
                245                 250                 255     
Phe His Gly Leu Thr Pro Gly Tyr Leu Tyr Asn Leu Thr Val Met Thr
            260                 265                 270         
Glu Ala Ala Gly Leu Gln Asn Tyr Arg Trp Lys Leu Val Arg Thr Ala
        275                 280                 285             
Pro Met Glu Val Ser Asn Leu Lys Val Thr Asn Asp Gly Ser Leu Thr
    290                 295                 300                 
Ser Leu Lys Val Lys Trp Gln Arg Pro Pro Gly Asn Val Asp Ser Tyr
305                 310                 315                 320 
Asn Ile Thr Leu Ser His Lys Gly Thr Ile Lys Glu Ser Arg Val Leu
                325                 330                 335     
Ala Pro Trp Ile Thr Glu Thr His Phe Lys Glu Leu Val Pro Gly Arg
            340                 345                 350         
Leu Tyr Gln Val Thr Val Ser Cys Val Ser Gly Glu Leu Ser Ala Gln
        355                 360                 365             
Lys Met Ala Val Gly Arg Thr Phe Pro Asp Lys Val Ala Asn Leu Glu
    370                 375                 380                 
Ala Asn Asn Asn Gly Arg Met Arg Ser Leu Val Val Ser Trp Ser Pro
385                 390                 395                 400 
Pro Ala Gly Asp Trp Glu Gln Tyr Arg Ile Leu Leu Phe Asn Asp Ser
                405                 410                 415     
Val Val Leu Leu Asn Ile Thr Val Gly Lys Glu Glu Thr Gln Tyr Val
            420                 425                 430         
Met Asp Asp Thr Gly Leu Val Pro Gly Arg Gln Tyr Glu Val Glu Val
        435                 440                 445             
Ile Val Glu Ser Gly Asn Leu Lys Asn Ser Glu Arg Cys Gln Gly Arg
    450                 455                 460                 
Thr Val Pro Leu Ala Val Leu Gln Leu Arg Val Lys His Ala Asn Glu
465                 470                 475                 480 
Thr Ser Leu Ser Ile Met Trp Gln Thr Pro Val Ala Glu Trp Glu Lys
                485                 490                 495     
Tyr Ile Ile Ser Leu Ala Asp Arg Asp Leu Leu Leu Ile His Lys Ser
            500                 505                 510         
Leu Ser Lys Asp Ala Lys Glu Phe Thr Phe Thr Asp Leu Val Pro Gly
        515                 520                 525             
Arg Lys Tyr Met Ala Thr Val Thr Ser Ile Ser Gly Asp Leu Lys Asn
    530                 535                 540                 
Ser Ser Ser Val Lys Gly Arg Thr Val Pro Ala Gln Val Thr Asp Leu
545                 550                 555                 560 
His Val Ala Asn Gln Gly Met Thr Ser Ser Leu Phe Thr Asn Trp Thr
                565                 570                 575     
Gln Ala Gln Gly Asp Val Glu Phe Tyr Gln Val Leu Leu Ile His Glu
            580                 585                 590         
Asn Val Val Ile Lys Asn Glu Ser Ile Ser Ser Glu Thr Ser Arg Tyr
        595                 600                 605             
Ser Phe His Ser Leu Lys Ser Gly Ser Leu Tyr Ser Val Val Val Thr
    610                 615                 620                 
Thr Val Ser Gly Gly Ile Ser Ser Arg Gln Val Val Val Glu Gly Arg
625                 630                 635                 640 
Thr Val Pro Ser Ser Val Ser Gly Val Thr Val Asn Asn Ser Gly Arg
                645                 650                 655     
Asn Asp Tyr Leu Ser Val Ser Trp Leu Leu Ala Pro Gly Asp Val Asp
            660                 665                 670         
Asn Tyr Glu Val Thr Leu Ser His Asp Gly Lys Val Val Gln Ser Leu
        675                 680                 685             
Val Ile Ala Lys Ser Val Arg Glu Cys Ser Phe Ser Ser Leu Thr Pro
    690                 695                 700                 
Gly Arg Leu Tyr Thr Val Thr Ile Thr Thr Arg Ser Gly Lys Tyr Glu
705                 710                 715                 720 
Asn His Ser Phe Ser Gln Glu Arg Thr Val Pro Asp Lys Val Gln Gly
                725                 730                 735     
Val Ser Val Ser Asn Ser Ala Arg Ser Asp Tyr Leu Arg Val Ser Trp
            740                 745                 750         
Val His Ala Thr Gly Asp Phe Asp His Tyr Glu Val Thr Ile Lys Asn
        755                 760                 765             
Lys Asn Asn Phe Ile Gln Thr Lys Ser Ile Pro Lys Ser Glu Asn Glu
    770                 775                 780                 
Cys Val Phe Val Gln Leu Val Pro Gly Arg Leu Tyr Ser Val Thr Val
785                 790                 795                 800 
Thr Thr Lys Ser Gly Gln Tyr Glu Ala Asn Glu Gln Gly Asn Gly Arg
                805                 810                 815     
Thr Ile Pro Glu Pro Val Lys Asp Leu Thr Leu Arg Asn Arg Ser Thr
            820                 825                 830         
Glu Asp Leu His Val Thr Trp Ser Gly Ala Asn Gly Asp Val Asp Gln
        835                 840                 845             
Tyr Glu Ile Gln Leu Leu Phe Asn Asp Met Lys Val Phe Pro Pro Phe
    850                 855                 860                 
His Leu Val Asn Thr Ala Thr Glu Tyr Arg Phe Thr Ser Leu Thr Pro
865                 870                 875                 880 
Gly Arg Gln Tyr Lys Ile Leu Val Leu Thr Ile Ser Gly Asp Val Gln
                885                 890                 895     
Gln Ser Ala Phe Ile Glu Gly Phe Thr Val Pro Ser Ala Val Lys Asn
            900                 905                 910         
Ile His Ile Ser Pro Asn Gly Ala Thr Asp Ser Leu Thr Val Asn Trp
        915                 920                 925             
Thr Pro Gly Gly Gly Asp Val Asp Ser Tyr Thr Val Ser Ala Phe Arg
    930                 935                 940                 
His Ser Gln Lys Val Asp Ser Gln Thr Ile Pro Lys His Val Phe Glu
945                 950                 955                 960 
His Thr Phe His Arg Leu Glu Ala Gly Glu Gln Tyr Gln Ile Met Ile
                965                 970                 975     
Ala Ser Val Ser Gly Ser Leu Lys Asn Gln Ile Asn Val Val Gly Arg
            980                 985                 990         
Thr Val Pro Ala Ser Val Gln Gly Val Ile Ala Asp Asn Ala Tyr Ser
        995                 1000                1005            
Ser Tyr Ser Leu Ile Val Ser Trp Gln Lys Ala Ala Gly Val Ala Glu
    1010                1015                1020                
Arg Tyr Asp Ile Leu Leu Leu Thr Glu Asn Gly Ile Leu Leu Arg Asn
1025                1030                1035                1040
Thr Ser Glu Pro Ala Thr Thr Lys Gln His Lys Phe Glu Asp Leu Thr
                1045                1050                1055    
Pro Gly Lys Lys Tyr Lys Ile Gln Ile Leu Thr Val Ser Gly Gly Leu
            1060                1065                1070        
Phe Ser Lys Glu Ala Gln Thr Glu Gly Arg Thr Val Pro Ala Ala Val
        1075                1080                1085            
Thr Asp Leu Arg Ile Thr Glu Asn Ser Thr Arg His Leu Ser Phe Arg
    1090                1095                1100                
Trp Thr Ala Ser Glu Gly Glu Leu Ser Trp Tyr Asn Ile Phe Leu Tyr
1105                1110                1115                1120
Asn Pro Asp Gly Asn Leu Gln Glu Arg Ala Gln Val Asp Pro Leu Val
                1125                1130                1135    
Gln Ser Phe Ser Phe Gln Asn Leu Leu Gln Gly Arg Met Tyr Lys Met
            1140                1145                1150        
Val Ile Val Thr His Ser Gly Glu Leu Ser Asn Glu Ser Phe Ile Phe
        1155                1160                1165            
Gly Arg Thr Val Pro Ala Ser Val Ser His Leu Arg Gly Ser Asn Arg
    1170                1175                1180                
Asn Thr Thr Asp Ser Leu Trp Phe Asn Trp Ser Pro Ala Ser Gly Asp
1185                1190                1195                1200
Phe Asp Phe Tyr Glu Leu Ile Leu Tyr Asn Pro Asn Gly Thr Lys Lys
                1205                1210                1215    
Glu Asn Trp Lys Asp Lys Asp Leu Thr Glu Trp Arg Phe Gln Gly Leu
            1220                1225                1230        
Val Pro Gly Arg Lys Tyr Val Leu Trp Val Val Thr His Ser Gly Asp
        1235                1240                1245            
Leu Ser Asn Lys Val Thr Ala Glu Ser Arg Thr Ala Pro Ser Pro Pro
    1250                1255                1260                
Ser Leu Met Ser Phe Ala Asp Ile Ala Asn Thr Ser Leu Ala Ile Thr
1265                1270                1275                1280
Trp Lys Gly Pro Pro Asp Trp Thr Asp Tyr Asn Asp Phe Glu Leu Gln
                1285                1290                1295    
Trp Leu Pro Arg Asp Ala Leu Thr Val Phe Asn Pro Tyr Asn Asn Arg
            1300                1305                1310        
Lys Ser Glu Gly Arg Ile Val Tyr Gly Leu Arg Pro Gly Arg Ser Tyr
        1315                1320                1325            
Gln Phe Asn Val Lys Thr Val Ser Gly Asp Ser Trp Lys Thr Tyr Ser
    1330                1335                1340                
Lys Pro Ile Phe Gly Ser Val Arg Thr Lys Pro Asp Lys Ile Gln Asn
1345                1350                1355                1360
Leu His Cys Arg Pro Gln Asn Ser Thr Ala Ile Ala Cys Ser Trp Ile
                1365                1370                1375    
Pro Pro Asp Ser Asp Phe Asp Gly Tyr Ser Ile Glu Cys Arg Lys Met
            1380                1385                1390        
Asp Thr Gln Glu Val Glu Phe Ser Arg Lys Leu Glu Lys Glu Lys Ser
        1395                1400                1405            
Leu Leu Asn Ile Met Met Leu Val Pro His Lys Arg Tyr Leu Val Ser
    1410                1415                1420                
Ile Lys Val Gln Ser Ala Gly Met Thr Ser Glu Val Val Glu Asp Ser
1425                1430                1435                1440
Thr Ile Thr Met Ile Asp Arg Pro Pro Pro Pro Pro Pro His Ile Arg
                1445                1450                1455    
Val Asn Glu Lys Asp Val Leu Ile Ser Lys Ser Ser Ile Asn Phe Thr
            1460                1465                1470        
Val Asn Cys Ser Trp Phe Ser Asp Thr Asn Gly Ala Val Lys Tyr Phe
        1475                1480                1485            
Thr Val Val Val Arg Glu Ala Asp Gly Ser Asp Glu Leu Lys Pro Glu
    1490                1495                1500                
Gln Gln His Pro Leu Pro Ser Tyr Leu Glu Tyr Arg His Asn Ala Ser
1505                1510                1515                1520
Ile Arg Val Tyr Gln Thr Asn Tyr Phe Ala Ser Lys Cys Ala Glu Asn
                1525                1530                1535    
Pro Asn Ser Asn Ser Lys Ser Phe Asn Ile Lys Leu Gly Ala Glu Met
            1540                1545                1550        
Glu Ser Leu Gly Gly Lys Cys Asp Pro Thr Gln Gln Lys Phe Cys Asp
        1555                1560                1565            
Gly Pro Leu Lys Pro His Thr Ala Tyr Arg Ile Ser Ile Arg Ala Phe
    1570                1575                1580                
Thr Gln Leu Phe Asp Glu Asp Leu Lys Glu Phe Thr Lys Pro Leu Tyr
1585                1590                1595                1600
Ser Asp Thr Phe Phe Ser Leu Pro Ile Thr Thr Glu Ser Glu Pro Leu
                1605                1610                1615    
Phe Gly Ala Ile Glu Gly Val Ser Ala Gly Leu Phe Leu Ile Gly Met
            1620                1625                1630        
Leu Val Ala Val Val Ala Leu Leu Ile Cys Arg Gln Lys Val Ser His
        1635                1640                1645            
Gly Arg Glu Arg Pro Ser Ala Arg Leu Ser Ile Arg Arg Asp Arg Pro
    1650                1655                1660                
Leu Ser Val His Leu Asn Leu Gly Gln Lys Gly Asn Arg Lys Thr Ser
1665                1670                1675                1680
Cys Pro Ile Lys Ile Asn Gln Phe Glu Gly His Phe Met Lys Leu Gln
                1685                1690                1695    
Ala Asp Ser Asn Tyr Leu Leu Ser Lys Glu Tyr Glu Glu Leu Lys Asp
            1700                1705                1710        
Val Gly Arg Asn Gln Ser Cys Asp Ile Ala Leu Leu Pro Glu Asn Arg
        1715                1720                1725            
Gly Lys Asn Arg Tyr Asn Asn Ile Leu Pro Tyr Asp Ala Thr Arg Val
    1730                1735                1740                
Lys Leu Ser Asn Val Asp Asp Asp Pro Cys Ser Asp Tyr Ile Asn Ala
1745                1750                1755                1760
Ser Tyr Ile Pro Gly Asn Asn Phe Arg Arg Glu Tyr Ile Val Thr Gln
                1765                1770                1775    
Gly Pro Leu Pro Gly Thr Lys Asp Asp Phe Trp Lys Met Val Trp Glu
            1780                1785                1790        
Gln Asn Val His Asn Ile Val Met Val Thr Gln Cys Val Glu Lys Gly
        1795                1800                1805            
Arg Val Lys Cys Asp His Tyr Trp Pro Ala Asp Gln Asp Ser Leu Tyr
    1810                1815                1820                
Tyr Gly Asp Leu Ile Leu Gln Met Leu Ser Glu Ser Val Leu Pro Glu
1825                1830                1835                1840
Trp Thr Ile Arg Glu Phe Lys Ile Cys Gly Glu Glu Gln Leu Asp Ala
                1845                1850                1855    
His Arg Leu Ile Arg His Phe His Tyr Thr Val Trp Pro Asp His Gly
            1860                1865                1870        
Val Pro Glu Thr Thr Gln Ser Leu Ile Gln Phe Val Arg Thr Val Arg
        1875                1880                1885            
Asp Tyr Ile Asn Arg Ser Pro Gly Ala Gly Pro Thr Val Val His Cys
    1890                1895                1900                
Ser Ala Gly Val Gly Arg Thr Gly Thr Phe Ile Ala Leu Asp Arg Ile
1905                1910                1915                1920
Leu Gln Gln Leu Asp Ser Lys Asp Ser Val Asp Ile Tyr Gly Ala Val
                1925                1930                1935    
His Asp Leu Arg Leu His Arg Val His Met Val Gln Thr Glu Cys Gln
            1940                1945                1950        
Tyr Val Tyr Leu His Gln Cys Val Arg Asp Val Leu Arg Ala Arg Lys
        1955                1960                1965            
Leu Arg Ser Glu Gln Glu Asn Pro Leu Phe Pro Ile Tyr Glu Asn Val
    1970                1975                1980                
Asn Pro Glu Tyr His Arg Asp Pro Val Tyr Ser Arg His
1985                1990                1995        


<210> 2136
<211> 434
<212> PRT
<213> Homo sapiens

<400> 2136
Met Glu Leu Lys Asp Leu His Gln Pro Lys Arg Lys Leu Thr Pro Trp
 1               5                  10                  15      
Lys His Gln Arg Leu Gly Lys Val Asn Ser Glu Tyr Arg Ala Lys Phe
            20                  25                  30          
Leu Ser Pro Ala Gln Tyr Leu Tyr Lys Ala Gly Ala Trp Thr His Val
        35                  40                  45              
Lys Gly Asn Met Pro Asn Gln Val Lys Glu Leu Arg Glu Lys Ala Glu
    50                  55                  60                  
Phe Tyr Arg Lys Arg Val Gln Gly Thr His Phe Ser Arg Asp His Leu
65                  70                  75                  80  
Asn Gln Ile Leu Ser Asp Ser Asn Cys Cys Trp Asp Val Ser Ser Thr
                85                  90                  95      
Thr Ser Ser Glu Gly Thr Val Ser Ser Asn Ile Arg Ala Leu Asp Leu
            100                 105                 110         
Ala Gly Asp Pro Thr Ser His Lys Thr Leu Gln Lys Cys Pro Ser Thr
        115                 120                 125             
Glu Pro Glu Glu Lys Gly Asn Ile Val Glu Glu Gln Pro Gln Lys Asn
    130                 135                 140                 
Thr Thr Glu Lys Leu Gly Val Ser Ala Pro Thr Ile Pro Val Arg Arg
145                 150                 155                 160 
Arg Leu Ala Trp Asp Thr Glu Asn Thr Ser Glu Asp Val Gln Lys Gln
                165                 170                 175     
Pro Gly Glu Lys Glu Glu Glu Asp Asp Asn Glu Glu Glu Gly Asp Arg
            180                 185                 190         
Lys Thr Gly Lys Gln Ala Phe Met Gly Glu Gln Glu Lys Leu Asp Val
        195                 200                 205             
Arg Glu Lys Ser Lys Ala Asp Lys Met Lys Glu Gly Ser Asp Ser Ser
    210                 215                 220                 
Val Ser Ser Glu Lys Gly Gly Arg Leu Pro Thr Pro Lys Leu Arg Glu
225                 230                 235                 240 
Leu Gly Gly Ile Gln Arg Thr His His Asp Leu Thr Thr Pro Ala Val
                245                 250                 255     
Gly Gly Ala Val Leu Val Ser Pro Ser Lys Met Lys Pro Pro Ala Pro
            260                 265                 270         
Glu Gln Arg Lys Arg Met Thr Ser Gln Asp Cys Leu Glu Thr Ser Lys
        275                 280                 285             
Asn Asp Phe Thr Lys Lys Glu Ser Arg Ala Val Ser Leu Leu Thr Ser
    290                 295                 300                 
Pro Ala Ala Gly Ile Lys Thr Val Asp Pro Leu Pro Leu Arg Glu Asp
305                 310                 315                 320 
Ser Glu Asp Asn Ile His Lys Phe Ala Glu Ala Thr Leu Pro Val Ser
                325                 330                 335     
Lys Ile Pro Lys Tyr Pro Thr Asn Pro Pro Gly Gln Leu Pro Ser Pro
            340                 345                 350         
Pro His Val Pro Ser Tyr Trp His Pro Ser Arg Arg Ile Gln Gly Ser
        355                 360                 365             
Leu Arg Asp Pro Glu Phe Gln His Asn Val Gly Lys Ala Arg Met Asn
    370                 375                 380                 
Asn Leu Gln Leu Pro Gln His Glu Ala Phe Asn Asp Glu Asp Glu Asp
385                 390                 395                 400 
Arg Leu Ser Glu Ile Ser Ala Arg Ser Ala Ala Ser Ser Leu Arg Ala
                405                 410                 415     
Phe Gln Thr Leu Ala Arg Ala Lys Lys Arg Lys Glu Asn Phe Trp Gly
            420                 425                 430         
Lys Thr
        


<210> 2137
<211> 257
<212> PRT
<213> Homo sapiens

<400> 2137
Met Glu Ala Cys Val Ser Ser Leu Leu Val Leu Ala Leu Gly Ala Leu
 1               5                  10                  15      
Ser Val Gly Ser Ser Phe Gly Thr Gln Ile Ile Gly Gly Arg Glu Val
            20                  25                  30          
Ile Pro His Ser Arg Pro Tyr Met Ala Ser Leu Gln Arg Asn Gly Ser
        35                  40                  45              
His Leu Cys Gly Gly Val Leu Val His Pro Lys Trp Val Leu Thr Ala
    50                  55                  60                  
Ala His Cys Leu Ala Gln Arg Met Ala Gln Leu Arg Leu Val Leu Gly
65                  70                  75                  80  
Leu His Thr Leu Asp Ser Pro Gly Leu Thr Phe His Ile Lys Ala Ala
                85                  90                  95      
Ile Gln His Pro Arg Tyr Lys Pro Val Pro Ala Leu Glu Asn Asp Leu
            100                 105                 110         
Ala Leu Leu Gln Leu Asp Gly Lys Val Lys Pro Ser Arg Thr Ile Arg
        115                 120                 125             
Pro Leu Ala Leu Pro Ser Lys Arg Gln Val Val Ala Ala Gly Thr Arg
    130                 135                 140                 
Cys Ser Met Ala Gly Trp Gly Leu Thr His Gln Gly Gly Arg Leu Ser
145                 150                 155                 160 
Arg Val Leu Arg Glu Leu Asp Leu Gln Val Leu Asp Thr Arg Met Cys
                165                 170                 175     
Asn Asn Ser Arg Phe Trp Asn Gly Ser Leu Ser Pro Ser Met Val Cys
            180                 185                 190         
Leu Ala Ala Asp Ser Lys Asp Gln Ala Pro Cys Lys Gly Asp Ser Gly
        195                 200                 205             
Gly Pro Leu Val Cys Gly Lys Gly Arg Val Leu Ala Arg Val Leu Ser
    210                 215                 220                 
Phe Ser Ser Arg Val Cys Thr Asp Ile Phe Lys Pro Pro Val Ala Thr
225                 230                 235                 240 
Ala Val Ala Pro Tyr Val Ser Trp Ile Arg Lys Val Thr Gly Arg Ser
                245                 250                 255     
Ala
    


<210> 2138
<211> 108
<212> PRT
<213> Homo sapiens

<400> 2138
Met Ala Asp Pro Arg Val Arg Gln Ile Lys Ile Lys Thr Gly Val Val
 1               5                  10                  15      
Lys Arg Leu Val Lys Glu Lys Val Met Tyr Glu Lys Glu Ala Lys Gln
            20                  25                  30          
Gln Glu Glu Lys Ile Glu Lys Met Arg Ala Glu Asp Gly Glu Asn Tyr
        35                  40                  45              
Asp Ile Lys Lys Gln Ala Glu Ile Leu Gln Glu Ser Arg Met Met Ile
    50                  55                  60                  
Pro Asp Cys Gln Arg Arg Leu Glu Ala Ala Tyr Leu Asp Leu Gln Gln
65                  70                  75                  80  
Ile Leu Glu Ser Glu Lys Asp Leu Glu Glu Ala Glu Glu Tyr Lys Glu
                85                  90                  95      
Ala Arg Leu Val Leu Asp Ser Val Lys Leu Glu Ala
            100                 105             


<210> 2139
<211> 340
<212> PRT
<213> Homo sapiens

<400> 2139
Met Ala Lys Trp Leu Arg Asp Tyr Leu Ser Phe Gly Gly Arg Arg Pro
 1               5                  10                  15      
Pro Pro Gln Pro Pro Thr Pro Asp Tyr Thr Glu Ser Asp Ile Leu Arg
            20                  25                  30          
Ala Tyr Arg Ala Gln Lys Asn Leu Asp Phe Glu Asp Pro Tyr Glu Asp
        35                  40                  45              
Ala Glu Ser Arg Leu Glu Pro Asp Pro Ala Gly Pro Gly Asp Ser Lys
    50                  55                  60                  
Asn Pro Gly Asp Ala Lys Tyr Gly Ser Pro Lys His Arg Leu Ile Lys
65                  70                  75                  80  
Val Glu Ala Ala Asp Met Ala Arg Ala Lys Ala Leu Leu Gly Gly Pro
                85                  90                  95      
Gly Glu Glu Leu Glu Ala Asp Thr Glu Tyr Leu Asp Pro Phe Asp Ala
            100                 105                 110         
Gln Pro His Pro Ala Pro Pro Asp Asp Gly Tyr Met Glu Pro Tyr Asp
        115                 120                 125             
Ala Gln Trp Val Met Ser Glu Leu Pro Gly Arg Gly Val Gln Leu Tyr
    130                 135                 140                 
Asp Thr Pro Tyr Glu Glu Gln Asp Pro Glu Thr Ala Asp Gly Pro Pro
145                 150                 155                 160 
Ser Gly Gln Lys Pro Arg Gln Ser Arg Met Pro Gln Glu Asp Glu Arg
                165                 170                 175     
Pro Ala Asp Glu Tyr Asp Gln Pro Trp Glu Trp Lys Lys Asp His Ile
            180                 185                 190         
Ser Arg Ala Phe Ala Val Gln Phe Asp Ser Pro Glu Trp Glu Arg Thr
        195                 200                 205             
Pro Gly Ser Ala Lys Glu Leu Arg Arg Pro Pro Pro Arg Ser Pro Gln
    210                 215                 220                 
Pro Ala Glu Arg Val Asp Pro Ala Leu Pro Leu Glu Lys Gln Pro Trp
225                 230                 235                 240 
Phe His Gly Pro Leu Asn Arg Ala Asp Ala Glu Ser Leu Leu Ser Leu
                245                 250                 255     
Cys Lys Glu Gly Ser Tyr Leu Val Arg Leu Ser Glu Thr Asn Pro Gln
            260                 265                 270         
Asp Cys Ser Leu Ser Leu Arg Ser Ser Gln Gly Phe Leu His Leu Lys
        275                 280                 285             
Phe Ala Arg Thr Arg Glu Asn Gln Val Val Leu Gly Gln His Ser Gly
    290                 295                 300                 
Pro Phe Pro Ser Val Pro Glu Leu Val Leu His Tyr Ser Ser Arg Pro
305                 310                 315                 320 
Leu Pro Val Gln Gly Ala Glu His Leu Ala Leu Leu Tyr Pro Val Val
                325                 330                 335     
Thr Gln Thr Pro
            340 


<210> 2140
<211> 575
<212> PRT
<213> Homo sapiens

<400> 2140
Met Ser Thr Phe Arg Gln Glu Asp Val Glu Asp His Tyr Glu Met Gly
 1               5                  10                  15      
Glu Glu Leu Gly Ser Gly Gln Phe Ala Ile Val Arg Lys Cys Arg Gln
            20                  25                  30          
Lys Gly Thr Gly Lys Glu Tyr Ala Ala Lys Phe Ile Lys Lys Arg Arg
        35                  40                  45              
Leu Ser Ser Ser Arg Arg Gly Val Ser Arg Glu Glu Ile Glu Arg Glu
    50                  55                  60                  
Val Asn Ile Leu Arg Glu Ile Arg His Pro Asn Ile Ile Thr Leu His
65                  70                  75                  80  
Asp Ile Phe Glu Asn Lys Thr Asp Val Val Leu Ile Leu Glu Leu Val
                85                  90                  95      
Ser Gly Gly Glu Leu Phe Asp Phe Leu Ala Glu Lys Glu Ser Leu Thr
            100                 105                 110         
Glu Asp Glu Ala Thr Gln Phe Leu Lys Gln Ile Leu Asp Gly Val His
        115                 120                 125             
Tyr Leu His Ser Lys Arg Ile Ala His Phe Asp Leu Lys Pro Glu Asn
    130                 135                 140                 
Ile Met Leu Leu Asp Lys Asn Val Pro Asn Pro Arg Ile Lys Leu Ile
145                 150                 155                 160 
Asp Phe Gly Ile Ala His Lys Ile Glu Ala Gly Asn Glu Phe Lys Asn
                165                 170                 175     
Ile Phe Gly Thr Pro Glu Phe Val Ala Pro Glu Ile Val Asn Tyr Glu
            180                 185                 190         
Pro Leu Gly Leu Glu Ala Asp Met Trp Ser Ile Gly Val Ile Thr Tyr
        195                 200                 205             
Ile Leu Leu Ser Gly Ala Ser Pro Phe Leu Gly Glu Thr Lys Gln Glu
    210                 215                 220                 
Thr Leu Thr Asn Ile Ser Ala Val Asn Tyr Asp Phe Asp Glu Glu Tyr
225                 230                 235                 240 
Phe Ser Asn Thr Ser Glu Leu Ala Lys Asp Phe Ile Arg Arg Leu Leu
                245                 250                 255     
Val Lys Asp Pro Lys Arg Arg Met Thr Ile Ala Gln Ser Leu Glu His
            260                 265                 270         
Ser Trp Ile Lys Ala Ile Arg Arg Arg Asn Val Arg Gly Glu Asp Ser
        275                 280                 285             
Gly Arg Lys Pro Glu Arg Ala Ala Pro Glu Asp His Ala Ser Glu Gly
    290                 295                 300                 
Val His His Gln Val Ala Leu Gln Leu Ala Ala Gln Gln Gln Leu Arg
305                 310                 315                 320 
Arg Leu Arg Ala Leu Leu Gln Gly Ala Gly Gly Gly Gly Gly Arg Arg
                325                 330                 335     
Gly Gly Pro Ala Arg Ala Ala Ala Gln Pro Ala Ala Leu Pro Arg Gly
            340                 345                 350         
Arg Gly Gly Ala Gly Arg His Leu Arg Gly Glu Gly Gly Leu Val Pro
        355                 360                 365             
Arg Gly Glu Arg Gln Pro Gly Pro Gly Pro Ala Glu Ala Thr Ala Gly
    370                 375                 380                 
Ala Ala Gln Asp Arg Gly Ala Gln Ala Ala Gly Ala Gly Gly Gly Gln
385                 390                 395                 400 
Gly Arg Ala Ala Gly Asp Gln Arg Pro Gln Ala Pro Leu Gln Pro Pro
                405                 410                 415     
Gly Glu Pro Leu Arg Gly Ala Gly Gln Ala Ser Ser Leu Arg Asp Ala
            420                 425                 430         
Leu Arg Ala Gly Pro Arg Ala Arg Pro Gly Ala Gly Glu Ala Ala Gly
        435                 440                 445             
Arg Gly Val Arg Ala Ala Leu Gly Ala Val Gly Trp Ala Arg Pro Gln
    450                 455                 460                 
Asp Ser Arg Ser Ser Ala Cys Gly Gly Gly Ala Ser Cys Gly Arg Cys
465                 470                 475                 480 
Ala Ser His Arg Pro Gly Ala Cys Pro Cys Pro Ala Pro Pro Gly Trp
                485                 490                 495     
Arg Arg Ser Gly Arg Ser Trp Ser Gln Ala Arg Lys Phe Ala Gly Arg
            500                 505                 510         
Gly Gly Cys Gly Thr Gly Leu Leu Leu Tyr Thr Ala Ser Thr Leu Ala
        515                 520                 525             
Phe Thr Phe Thr Pro Ala Ser Ser Val Thr Leu Gly Pro Ser Arg Gln
    530                 535                 540                 
Arg Gly Leu Trp His Arg Glu Gly Trp Asp Pro Pro Arg Arg Arg Gly
545                 550                 555                 560 
Gly Pro Asn Ala Ala Leu Val Gln Ala Arg Arg Arg Val Cys Gly
                565                 570                 575 


<210> 2141
<211> 455
<212> PRT
<213> Homo sapiens

<400> 2141
Met Pro Lys Glu Tyr Arg Cys Gly Ser Trp Leu Arg Cys Arg Leu Gln
 1               5                  10                  15      
Ser Asp Pro Trp Arg Ala Glu Lys Gln Ser Ala Asn Leu Arg Ala Glu
            20                  25                  30          
Arg Leu Glu Lys Glu Leu Gln Ser Ser Ser Glu Gln Asn Thr Phe Leu
        35                  40                  45              
Ile Asn Lys Leu His Lys Ala Glu Arg Glu Ile Asn Thr Leu Ser Ser
    50                  55                  60                  
Lys Val Lys Glu Leu Lys His Ser Asn Lys Leu Glu Ile Thr Asp Ile
65                  70                  75                  80  
Lys Leu Glu Thr Ala Arg Ala Lys Ser Glu Leu Glu Arg Glu Arg Asn
                85                  90                  95      
Lys Ile Gln Ser Glu Leu Asp Gly Leu Gln Ser Asp Asn Glu Ile Leu
            100                 105                 110         
Lys Ala Ala Val Glu His His Lys Val Leu Leu Val Glu Lys Asp Arg
        115                 120                 125             
Glu Leu Ile Arg Lys Val Gln Ala Ala Lys Glu Glu Gly Tyr Gln Lys
    130                 135                 140                 
Leu Val Val Leu Gln Asp Glu Lys Leu Glu Leu Glu Asn Arg Leu Ala
145                 150                 155                 160 
Asp Leu Glu Lys Met Lys Val Glu His Asp Val Trp Arg Gln Ser Glu
                165                 170                 175     
Lys Asp Gln Tyr Glu Glu Lys Leu Arg Ala Ser Gln Met Ala Glu Glu
            180                 185                 190         
Ile Thr Arg Lys Glu Leu Gln Ser Val Arg Leu Lys Leu Gln Gln Gln
        195                 200                 205             
Ile Val Thr Ile Glu Asn Ala Glu Lys Glu Lys Asn Glu Asn Ser Asp
    210                 215                 220                 
Leu Lys Gln Gln Ile Ser Ser Leu Gln Ile Gln Val Thr Ser Leu Ala
225                 230                 235                 240 
Gln Ser Glu Asn Asp Leu Leu Asn Ser Asn Gln Met Leu Lys Glu Met
                245                 250                 255     
Val Glu Arg Leu Lys Gln Glu Cys Arg Asn Phe Arg Ser Gln Ala Glu
            260                 265                 270         
Lys Ala Gln Leu Glu Ala Glu Lys Thr Leu Glu Glu Lys Gln Ile Gln
        275                 280                 285             
Trp Leu Glu Glu Lys His Lys Leu His Glu Arg Ile Thr Asp Arg Glu
    290                 295                 300                 
Glu Lys Tyr Asn Gln Ala Lys Glu Lys Leu Gln Arg Ala Ala Ile Ala
305                 310                 315                 320 
Gln Lys Lys Arg Lys Ser Leu His Glu Asn Lys Leu Lys Arg Leu Gln
                325                 330                 335     
Glu Lys Val Glu Val Leu Glu Ala Lys Lys Glu Glu Leu Glu Thr Glu
            340                 345                 350         
Asn Gln Val Leu Asn Arg Gln Asn Val Pro Phe Glu Asp Tyr Thr Arg
        355                 360                 365             
Leu Gln Lys Arg Leu Lys Asp Ile Gln Arg Arg His Asn Glu Phe Arg
    370                 375                 380                 
Ser Leu Ile Leu Val Pro Asn Met Pro Pro Thr Ala Ser Ile Asn Pro
385                 390                 395                 400 
Val Ser Phe Gln Ser Ser Ala Met Val Pro Ser Met Glu Leu Pro Phe
                405                 410                 415     
Pro Pro His Met Gln Glu Glu Gln His Gln Arg Glu Leu Ser Leu Leu
            420                 425                 430         
Arg Lys Arg Leu Glu Glu Leu Glu Thr Thr Gln Arg Lys Gln Leu Glu
        435                 440                 445             
Glu Leu Gly Ser Ser Gly Glu
    450                 455 


<210> 2142
<211> 367
<212> PRT
<213> Homo sapiens

<400> 2142
Met Met Ala Gln Ser Asn Met Phe Thr Val Ala Asp Val Leu Ser Gln
 1               5                  10                  15      
Asp Glu Leu Arg Lys Lys Leu Tyr Gln Thr Phe Lys Asp Arg Gly Ile
            20                  25                  30          
Leu Asp Thr Leu Lys Thr Gln Leu Arg Asn Gln Leu Ile His Glu Leu
        35                  40                  45              
Met His Pro Val Leu Ser Gly Glu Leu Gln Pro Arg Ser Ile Ser Val
    50                  55                  60                  
Glu Gly Ser Ser Leu Leu Ile Gly Ala Ser Asn Ser Leu Val Ala Asp
65                  70                  75                  80  
His Leu Gln Arg Cys Gly Tyr Glu Tyr Ser Leu Ser Val Phe Phe Pro
                85                  90                  95      
Glu Ser Gly Leu Ala Lys Glu Lys Val Phe Thr Met Gln Asp Leu Leu
            100                 105                 110         
Gln Leu Ile Lys Ile Asn Pro Thr Ser Ser Leu Tyr Lys Ser Leu Val
        115                 120                 125             
Ser Gly Ser Asp Lys Glu Asn Gln Lys Gly Phe Leu Met His Phe Leu
    130                 135                 140                 
Lys Glu Leu Ala Glu Tyr His Gln Ala Lys Glu Ser Cys Asn Met Glu
145                 150                 155                 160 
Thr Gln Thr Ser Ser Thr Phe Asn Arg Asp Ser Leu Ala Glu Lys Leu
                165                 170                 175     
Gln Leu Ile Asp Asp Gln Phe Ala Asp Ala Tyr Pro Gln Arg Ile Lys
            180                 185                 190         
Phe Glu Ser Leu Glu Ile Lys Leu Asn Glu Tyr Lys Arg Glu Ile Glu
        195                 200                 205             
Glu Gln Leu Arg Ala Glu Met Cys Gln Lys Leu Lys Phe Phe Lys Asp
    210                 215                 220                 
Thr Glu Ile Ala Lys Ile Lys Met Glu Ala Lys Lys Lys Tyr Glu Lys
225                 230                 235                 240 
Glu Leu Thr Met Phe Gln Asn Asp Phe Glu Lys Ala Cys Gln Ala Lys
                245                 250                 255     
Ser Glu Ala Leu Val Leu Arg Glu Lys Ser Thr Leu Glu Arg Ile His
            260                 265                 270         
Lys His Gln Glu Ile Glu Thr Lys Glu Ile Tyr Ala Gln Arg Gln Leu
        275                 280                 285             
Leu Leu Lys Asp Met Asp Leu Leu Arg Gly Arg Glu Ala Glu Leu Lys
    290                 295                 300                 
Gln Arg Val Glu Ala Phe Glu Leu Asn Gln Lys Leu Gln Glu Glu Lys
305                 310                 315                 320 
His Lys Ser Ile Thr Glu Ala Leu Arg Arg Gln Glu Gln Asn Ile Lys
                325                 330                 335     
Ser Phe Glu Glu Thr Tyr Asp Arg Lys Leu Lys Asn Glu Leu Leu Asn
            340                 345                 350         
Phe His Arg Leu His Gly Val Cys Leu Ala Leu Gly Ile Leu Ile
        355                 360                 365         


<210> 2143
<211> 594
<212> PRT
<213> Homo sapiens

<400> 2143
Met Val Ser His Ile Leu Gln Ser Glu Leu Gly Asp Phe His Glu Glu
 1               5                  10                  15      
Thr Asp Arg Lys His Leu Ala Gln Thr Arg Tyr Leu Pro Asn Gln Asp
            20                  25                  30          
Cys Leu Glu Gly Lys Ile Met His Phe His Gln Lys His Ile Gly Arg
        35                  40                  45              
Ser Pro Ala Glu Ser Asp Ile Leu Leu Leu Asp Ile Ala Arg Lys Leu
    50                  55                  60                  
Asp Met Tyr Gly Ile Arg Pro His Pro Ala Ser Asp Gly Glu Gly Met
65                  70                  75                  80  
Gln Ile His Leu Ala Val Ala His Met Gly Val Leu Val Leu Arg Gly
                85                  90                  95      
Asn Thr Lys Ile Asn Thr Phe Asn Trp Ala Lys Ile Arg Lys Leu Ser
            100                 105                 110         
Phe Lys Arg Lys His Phe Leu Ile Lys Leu His Ala Asn Ile Leu Val
        115                 120                 125             
Leu Cys Lys Asp Thr Leu Glu Phe Thr Met Ala Ser Arg Asp Ala Cys
    130                 135                 140                 
Lys Ala Phe Trp Lys Thr Cys Val Glu Tyr His Ala Phe Phe Arg Leu
145                 150                 155                 160 
Ser Glu Glu Pro Lys Ser Lys Pro Lys Thr Leu Leu Cys Ser Lys Gly
                165                 170                 175     
Ser Ser Phe Arg Tyr Ser Gly Arg Thr Gln Arg Gln Leu Leu Glu Tyr
            180                 185                 190         
Gly Arg Lys Gly Arg Leu Lys Ser Leu Pro Phe Glu Arg Lys His Tyr
        195                 200                 205             
Pro Ser Gln Tyr His Glu Arg Gln Cys Arg Ser Ser Pro Asp Leu Leu
    210                 215                 220                 
Ser Asp Val Ser Lys Gln Val Glu Asp Leu Arg Leu Ala Tyr Gly Gly
225                 230                 235                 240 
Gly Tyr Tyr Gln Asn Val Asn Gly Val His Ala Ser Glu Pro Val Leu
                245                 250                 255     
Glu Ser Arg Arg Arg Asn Ser Ala Leu Glu Val Thr Phe Ala Thr Glu
            260                 265                 270         
Leu Glu His Ser Lys Pro Glu Ala Asp Pro Thr Leu Leu His Gln Ser
        275                 280                 285             
Gln Ser Ser Ser Ser Phe Pro Phe Ile Tyr Met Asp Pro Val Phe Asn
    290                 295                 300                 
Thr Glu Pro Asn Pro Asn Pro Asp Pro Arg Asp Ile Phe Ser Glu Arg
305                 310                 315                 320 
Ser Ser Leu Ser Ser Phe Gln Thr Ser Cys Lys Phe Ser Gly Asn His
                325                 330                 335     
Met Ser Ile Tyr Ser Gly Leu Thr Ser Lys Val Arg Pro Ala Lys Gln
            340                 345                 350         
Leu Thr Tyr Thr Asp Val Pro Tyr Ile Pro Cys Thr Gly Gln Gln Val
        355                 360                 365             
Gly Ile Met Pro Pro Gln Val Phe Phe Tyr Val Asp Lys Pro Pro Gln
    370                 375                 380                 
Val Pro Arg Trp Ser Pro Ile Arg Ala Glu Glu Arg Thr Ser Pro His
385                 390                 395                 400 
Ser Tyr Val Glu Pro Thr Ala Met Lys Pro Ala Glu Arg Ser Pro Arg
                405                 410                 415     
Asn Ile Arg Met Lys Ser Phe Gln Gln Asp Leu Gln Val Leu Gln Glu
            420                 425                 430         
Ala Ile Ala Arg Thr Ser Gly Arg Ser Asn Ile Asn Val Gly Leu Glu
        435                 440                 445             
Glu Glu Asp Pro Asn Leu Glu Asp Ala Phe Val Cys Asn Ile Gln Glu
    450                 455                 460                 
Gln Thr Pro Lys Arg Ser Gln Ser Gln Ser Asp Met Lys Thr Ile Arg
465                 470                 475                 480 
Phe Pro Phe Gly Ser Glu Phe Arg Pro Leu Gly Pro Cys Pro Ala Leu
                485                 490                 495     
Ser His Lys Ala Asp Leu Phe Thr Asp Met Phe Ala Glu Gln Glu Leu
            500                 505                 510         
Pro Ala Val Leu Met Asp Gln Ser Thr Ala Glu Arg Tyr Val Ala Ser
        515                 520                 525             
Glu Ser Ser Asp Ser Glu Ser Glu Ile Leu Lys Pro Asp Tyr Tyr Ala
    530                 535                 540                 
Leu Tyr Gly Lys Glu Ile Arg Ser Pro Met Ala Arg Ile Arg Leu Ser
545                 550                 555                 560 
Ser Gly Ser Leu Gln Leu Asp Glu Glu Asp Glu Asp Ala Tyr Phe Asn
                565                 570                 575     
Thr Pro Thr Ala Glu Asp Arg Thr Ser Leu Lys Pro Cys Asn Tyr Phe
            580                 585                 590         
Leu Ala
        


<210> 2144
<211> 397
<212> PRT
<213> Homo sapiens

<400> 2144
Met Ala Leu Leu Arg Gly Val Phe Val Val Ala Ala Lys Arg Thr Pro
 1               5                  10                  15      
Phe Gly Ala Tyr Gly Gly Leu Leu Lys Asp Phe Thr Ala Thr Asp Leu
            20                  25                  30          
Ser Glu Phe Ala Ala Lys Ala Ala Leu Ser Ala Gly Lys Val Ser Pro
        35                  40                  45              
Glu Thr Val Asp Ser Val Ile Met Gly Asn Val Leu Gln Ser Ser Ser
    50                  55                  60                  
Asp Ala Ile Tyr Leu Ala Arg His Val Gly Leu Arg Val Gly Ile Pro
65                  70                  75                  80  
Lys Glu Thr Pro Ala Leu Thr Ile Asn Arg Leu Cys Gly Ser Gly Phe
                85                  90                  95      
Gln Ser Ile Val Asn Gly Cys Gln Glu Ile Cys Val Lys Glu Ala Glu
            100                 105                 110         
Val Val Leu Cys Gly Gly Thr Glu Ser Met Ser Gln Ala Pro Tyr Cys
        115                 120                 125             
Val Arg Asn Val Arg Phe Gly Thr Lys Leu Gly Ser Asp Ile Lys Leu
    130                 135                 140                 
Glu Asp Ser Leu Trp Val Ser Leu Thr Asp Gln His Val Gln Leu Pro
145                 150                 155                 160 
Met Ala Met Thr Ala Glu Asn Leu Ala Val Lys His Lys Ile Ser Arg
                165                 170                 175     
Glu Glu Cys Asp Lys Tyr Ala Leu Gln Ser Gln Gln Arg Trp Lys Ala
            180                 185                 190         
Ala Asn Asp Ala Gly Tyr Phe Asn Asp Glu Met Ala Pro Ile Glu Val
        195                 200                 205             
Lys Thr Lys Lys Gly Lys Gln Thr Met Gln Val Asp Glu His Ala Arg
    210                 215                 220                 
Pro Gln Thr Thr Leu Glu Gln Leu Gln Lys Leu Pro Pro Val Phe Lys
225                 230                 235                 240 
Lys Asp Gly Thr Val Thr Ala Gly Asn Ala Ser Gly Val Ala Asp Gly
                245                 250                 255     
Ala Gly Ala Val Ile Ile Ala Ser Glu Asp Ala Val Lys Lys His Asn
            260                 265                 270         
Phe Thr Pro Leu Ala Arg Ile Val Gly Tyr Phe Val Ser Gly Cys Asp
        275                 280                 285             
Pro Ser Ile Met Gly Ile Gly Pro Val Pro Ala Ile Ser Gly Ala Leu
    290                 295                 300                 
Lys Lys Ala Gly Leu Ser Leu Lys Asp Met Asp Leu Val Glu Val Asn
305                 310                 315                 320 
Glu Ala Phe Ala Pro Gln Tyr Leu Ala Val Glu Arg Ser Leu Asp Leu
                325                 330                 335     
Asp Ile Ser Lys Thr Asn Val Asn Gly Gly Ala Ile Ala Leu Gly His
            340                 345                 350         
Pro Leu Gly Gly Ser Gly Ser Arg Ile Thr Ala His Leu Val His Glu
        355                 360                 365             
Leu Arg Arg Arg Gly Gly Lys Tyr Ala Val Gly Ser Ala Cys Ile Gly
    370                 375                 380                 
Gly Gly Gln Gly Ile Ala Val Ile Ile Gln Ser Thr Ala
385                 390                 395         


<210> 2145
<211> 252
<212> PRT
<213> Homo sapiens

<400> 2145
Met Ala Ala Ala Cys Arg Ser Val Lys Gly Leu Val Ala Val Ile Thr
 1               5                  10                  15      
Gly Gly Ala Ser Gly Leu Gly Leu Ala Thr Ala Glu Arg Leu Val Gly
            20                  25                  30          
Gln Gly Ala Ser Ala Val Leu Leu Asp Leu Pro Asn Ser Gly Gly Glu
        35                  40                  45              
Ala Gln Ala Lys Lys Leu Gly Asn Asn Cys Val Phe Ala Pro Ala Asp
    50                  55                  60                  
Val Thr Ser Glu Lys Asp Val Gln Thr Ala Leu Ala Leu Ala Lys Gly
65                  70                  75                  80  
Lys Phe Gly Arg Val Asp Val Ala Val Asn Cys Ala Gly Ile Ala Val
                85                  90                  95      
Ala Ser Lys Thr Tyr Asn Leu Lys Lys Gly Gln Thr His Thr Leu Glu
            100                 105                 110         
Asp Phe Gln Arg Val Leu Asp Val Asn Leu Met Gly Thr Phe Asn Val
        115                 120                 125             
Ile Arg Leu Val Ala Gly Glu Met Gly Gln Asn Glu Pro Asp Gln Gly
    130                 135                 140                 
Gly Gln Arg Gly Val Ile Ile Asn Thr Ala Ser Val Ala Ala Phe Glu
145                 150                 155                 160 
Gly Gln Val Gly Gln Ala Ala Tyr Ser Ala Ser Lys Gly Gly Ile Val
                165                 170                 175     
Gly Met Thr Leu Pro Ile Ala Arg Asp Leu Ala Pro Ile Gly Leu Phe
            180                 185                 190         
Gly Thr Pro Leu Leu Thr Ser Leu Pro Glu Lys Val Cys Asn Phe Leu
        195                 200                 205             
Ala Ser Gln Val Pro Phe Pro Ser Arg Leu Gly Asp Pro Ala Glu Tyr
    210                 215                 220                 
Ala His Leu Val Gln Ala Ile Ile Glu Asn Pro Phe Leu Asn Gly Glu
225                 230                 235                 240 
Val Ile Arg Leu Asp Gly Ala Ile Arg Met Gln Pro
                245                 250         


<210> 2146
<211> 347
<212> PRT
<213> Homo sapiens

<400> 2146
Met Arg Val Val Val Ile Gly Ala Gly Val Ile Gly Leu Ser Thr Ala
 1               5                  10                  15      
Leu Cys Ile His Glu Arg Tyr His Ser Val Leu Gln Pro Leu Asp Ile
            20                  25                  30          
Lys Val Tyr Ala Asp Arg Phe Thr Pro Leu Thr Thr Thr Asp Val Ala
        35                  40                  45              
Ala Gly Leu Trp Gln Pro Tyr Leu Ser Asp Pro Asn Asn Pro Gln Glu
    50                  55                  60                  
Ala Asp Trp Ser Gln Gln Thr Phe Asp Tyr Leu Leu Ser His Val His
65                  70                  75                  80  
Ser Pro Asn Ala Glu Asn Leu Gly Leu Phe Leu Ile Ser Gly Tyr Asn
                85                  90                  95      
Leu Phe His Glu Ala Ile Pro Asp Pro Ser Trp Lys Asp Thr Val Leu
            100                 105                 110         
Gly Phe Arg Lys Leu Thr Pro Arg Glu Leu Asp Met Phe Pro Asp Tyr
        115                 120                 125             
Gly Tyr Gly Trp Phe His Thr Ser Leu Ile Leu Glu Gly Lys Asn Tyr
    130                 135                 140                 
Leu Gln Trp Leu Thr Glu Arg Leu Thr Glu Arg Gly Val Lys Phe Phe
145                 150                 155                 160 
Gln Arg Lys Val Glu Ser Phe Glu Glu Val Ala Arg Glu Gly Ala Asp
                165                 170                 175     
Val Ile Val Asn Cys Thr Gly Val Trp Ala Gly Ala Leu Gln Arg Asp
            180                 185                 190         
Pro Leu Leu Gln Pro Gly Arg Gly Gln Ile Met Lys Val Asp Ala Pro
        195                 200                 205             
Trp Met Lys His Phe Ile Leu Thr His Asp Pro Glu Arg Gly Ile Tyr
    210                 215                 220                 
Asn Ser Pro Tyr Ile Ile Pro Gly Thr Gln Thr Val Thr Leu Gly Gly
225                 230                 235                 240 
Ile Phe Gln Leu Gly Asn Trp Ser Glu Leu Asn Asn Ile Gln Asp His
                245                 250                 255     
Asn Thr Ile Trp Glu Gly Cys Cys Arg Leu Glu Pro Thr Leu Lys Asn
            260                 265                 270         
Ala Arg Ile Ile Gly Glu Arg Thr Gly Phe Arg Pro Val Arg Pro Gln
        275                 280                 285             
Ile Arg Leu Glu Arg Glu Gln Leu Arg Thr Gly Pro Ser Asn Thr Glu
    290                 295                 300                 
Val Ile His Asn Tyr Gly His Gly Gly Tyr Gly Leu Thr Ile His Trp
305                 310                 315                 320 
Gly Cys Ala Leu Glu Ala Ala Lys Leu Phe Val Arg Ile Leu Glu Glu
                325                 330                 335     
Lys Lys Leu Ser Arg Met Pro Pro Ser His Leu
            340                 345         


<210> 2147
<211> 496
<212> PRT
<213> Homo sapiens

<400> 2147
Met Ser Ala Ser Glu Gly Met Lys Phe Lys Phe His Ser Gly Glu Lys
 1               5                  10                  15      
Val Leu Cys Phe Glu Pro Asp Pro Thr Lys Ala Arg Val Leu Tyr Asp
            20                  25                  30          
Ala Lys Ile Val Asp Val Ile Val Gly Lys Asp Glu Lys Gly Arg Lys
        35                  40                  45              
Ile Pro Glu Tyr Leu Ile His Phe Asn Gly Trp Asn Arg Ser Trp Asp
    50                  55                  60                  
Arg Trp Ala Ala Glu Asp His Val Leu Arg Asp Thr Asp Glu Asn Arg
65                  70                  75                  80  
Arg Leu Gln Arg Lys Leu Ala Arg Lys Ala Val Ala Arg Leu Arg Ser
                85                  90                  95      
Thr Gly Arg Lys Lys Lys Arg Cys Arg Leu Pro Gly Val Asp Ser Val
            100                 105                 110         
Leu Lys Gly Leu Pro Thr Glu Glu Lys Asp Glu Asn Asp Glu Asn Ser
        115                 120                 125             
Leu Ser Ser Ser Ser Asp Cys Ser Glu Asn Lys Asp Glu Glu Ile Ser
    130                 135                 140                 
Glu Glu Ser Asp Ile Glu Glu Lys Thr Glu Val Lys Glu Glu Pro Glu
145                 150                 155                 160 
Leu Gln Thr Arg Arg Glu Met Glu Glu Arg Thr Ile Thr Ile Glu Ile
                165                 170                 175     
Pro Glu Val Leu Lys Lys Gln Leu Glu Asp Asp Cys Tyr Tyr Ile Asn
            180                 185                 190         
Arg Arg Lys Arg Leu Val Lys Leu Pro Cys Gln Thr Asn Ile Ile Thr
        195                 200                 205             
Ile Leu Glu Ser Tyr Val Lys His Phe Ala Ile Asn Ala Ala Phe Ser
    210                 215                 220                 
Ala Asn Glu Arg Pro Arg His His His Val Met Pro His Ala Asn Met
225                 230                 235                 240 
Asn Val His Tyr Ile Pro Ala Glu Lys Asn Val Asp Leu Cys Lys Glu
                245                 250                 255     
Met Val Asp Gly Leu Arg Ile Thr Phe Asp Tyr Thr Leu Pro Leu Val
            260                 265                 270         
Leu Leu Tyr Pro Tyr Glu Gln Ala Gln Tyr Lys Lys Val Thr Ser Ser
        275                 280                 285             
Lys Phe Phe Leu Pro Ile Lys Glu Ser Ala Thr Ser Thr Asn Arg Ser
    290                 295                 300                 
Gln Glu Glu Leu Ser Pro Ser Pro Pro Leu Leu Asn Pro Ser Thr Pro
305                 310                 315                 320 
Gln Ser Thr Glu Ser Gln Pro Thr Thr Gly Glu Pro Ala Thr Pro Lys
                325                 330                 335     
Arg Arg Lys Ala Glu Pro Glu Ala Leu Gln Ser Leu Arg Arg Ser Thr
            340                 345                 350         
Arg His Ser Ala Asn Cys Asp Arg Leu Ser Glu Ser Ser Ala Ser Pro
        355                 360                 365             
Gln Pro Lys Arg Arg Gln Gln Asp Thr Ser Ala Ser Met Pro Lys Leu
    370                 375                 380                 
Phe Leu His Leu Glu Lys Lys Thr Pro Val His Ser Arg Ser Ser Ser
385                 390                 395                 400 
Pro Ile Pro Leu Thr Pro Ser Lys Glu Gly Ser Ala Val Phe Ala Gly
                405                 410                 415     
Phe Glu Gly Arg Arg Thr Asn Glu Ile Asn Glu Val Leu Ser Trp Lys
            420                 425                 430         
Leu Val Pro Asp Asn Tyr Pro Pro Gly Asp Gln Pro Pro Pro Pro Ser
        435                 440                 445             
Tyr Ile Tyr Gly Ala Gln His Leu Leu Arg Leu Phe Val Lys Leu Pro
    450                 455                 460                 
Glu Ile Leu Gly Lys Met Ser Phe Ser Glu Lys Asn Leu Lys Ala Leu
465                 470                 475                 480 
Leu Lys His Phe Asp Leu Phe Leu Arg Val Phe Ser Arg Ile Pro Arg
                485                 490                 495     


<210> 2148
<211> 283
<212> PRT
<213> Homo sapiens

<400> 2148
Met His His His Glu His His His Leu Gln Ala Pro Asn Lys Glu Asp
 1               5                  10                  15      
Ile Leu Lys Ile Ser Glu Asp Glu Arg Met Glu Leu Ser Lys Ser Phe
            20                  25                  30          
Arg Val Tyr Cys Ile Ile Leu Val Lys Pro Lys Asp Val Ser Leu Trp
        35                  40                  45              
Ala Ala Val Lys Glu Thr Trp Thr Lys His Cys Asp Lys Ala Glu Phe
    50                  55                  60                  
Phe Ser Ser Glu Asn Val Lys Val Phe Glu Ser Ile Asn Met Asp Thr
65                  70                  75                  80  
Asn Asp Met Trp Leu Met Met Arg Lys Ala Tyr Lys Tyr Ala Phe Asp
                85                  90                  95      
Lys Tyr Arg Asp Gln Tyr Asn Trp Phe Phe Leu Ala Arg Pro Thr Thr
            100                 105                 110         
Phe Ala Ile Ile Glu Asn Leu Lys Tyr Phe Leu Leu Lys Lys Asp Pro
        115                 120                 125             
Ser Gln Pro Phe Tyr Leu Gly His Thr Ile Lys Ser Gly Asp Leu Glu
    130                 135                 140                 
Tyr Val Gly Met Glu Gly Gly Ile Val Leu Ser Val Glu Ser Met Lys
145                 150                 155                 160 
Arg Leu Asn Ser Leu Leu Asn Ile Pro Glu Lys Cys Pro Glu Gln Gly
                165                 170                 175     
Gly Met Ile Trp Lys Ile Ser Glu Asp Lys Gln Leu Ala Val Cys Leu
            180                 185                 190         
Lys Tyr Ala Gly Val Phe Ala Glu Asn Ala Glu Asp Ala Asp Gly Lys
        195                 200                 205             
Asp Val Phe Asn Thr Lys Ser Val Gly Leu Ser Ile Lys Glu Ala Met
    210                 215                 220                 
Thr Tyr His Pro Asn Gln Val Val Glu Gly Cys Cys Ser Asp Met Ala
225                 230                 235                 240 
Val Thr Phe Asn Gly Leu Thr Pro Asn Gln Met His Val Met Met Tyr
                245                 250                 255     
Gly Val Tyr Arg Leu Arg Ala Phe Gly His Ile Phe Asn Asp Ala Leu
            260                 265                 270         
Val Phe Leu Pro Pro Asn Gly Ser Asp Asn Asp
        275                 280             


<210> 2149
<211> 828
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 670, 671, 672, 673
<223> Xaa = Any Amino Acid

<400> 2149
Met Leu Ala Gln Glu Ser Tyr Pro Lys Lys Arg Asn Tyr Thr Met Glu
 1               5                  10                  15      
Ile Val Pro Ser Ala Ser Leu Asp Thr Phe Pro Ser Glu Asn Glu Asn
            20                  25                  30          
Phe Leu Cys Asp Leu Met Asp Thr Ala Val Thr Lys Lys Pro Cys Ser
        35                  40                  45              
Leu Glu Ile Ala Arg Ala Pro Ser Pro Arg Thr Asp Asn Ala Ser Glu
    50                  55                  60                  
Val Ala Val Thr Thr Pro Gly Thr Ser Asn His Arg Asn Ser Ser Thr
65                  70                  75                  80  
Gly Pro Thr Pro Asp Cys Ser Pro Pro Ser Pro Asp Thr Ala Leu Lys
                85                  90                  95      
Asn Ile Val Lys Val Ile Arg Pro Gln Pro Lys Gln Arg Thr Ser Ile
            100                 105                 110         
Val Ser Ser Leu Asp Phe His Arg Met Asn His Asn Gln Glu Tyr Phe
        115                 120                 125             
Glu Ile Asn Thr Ser Thr Gly Cys Thr Ser Phe Thr Ala Ser Pro Pro
    130                 135                 140                 
Ala Ser Pro Pro Thr Ser Ser Val Gly Thr Thr Glu Val Lys Asn Glu
145                 150                 155                 160 
Gly Thr Asn His Thr Asp Asp Leu Ser Arg Gln Asp Asp Asn Asp Pro
                165                 170                 175     
Pro Lys Glu Tyr Asp Pro Gly Gln Phe Ala Gly Leu Leu His Gly Ser
            180                 185                 190         
Ser Pro Ala Cys Glu Ser Pro Glu Asn Pro Phe His Leu Tyr Gly Lys
        195                 200                 205             
Arg Glu Gln Cys Glu Lys Gly Gln Asp Glu Val Ser Leu Ala Asn Ser
    210                 215                 220                 
Pro Leu Pro Phe Lys Gln Ser Pro Ile Glu Asn Asn Ser Glu Pro Leu
225                 230                 235                 240 
Val Lys Lys Ile Lys Pro Lys Val Val Ser Arg Thr Ile Phe His Lys
                245                 250                 255     
Lys Ser Asn Gln Leu Glu Asn His Thr Ile Val Gly Thr Arg Ser Thr
            260                 265                 270         
Arg Ser Gly Ser Arg Asn Gly Asp Gln Trp Val Met Asn Ala Gly Gly
        275                 280                 285             
Phe Val Glu Arg Ala Cys Thr Leu Gly Arg Ile Arg Ser Leu Pro Lys
    290                 295                 300                 
Ala Leu Ile Asp Met His Leu Ser Lys Ser Val Ser Lys Ser Asp Ser
305                 310                 315                 320 
Asp Leu Ile Ala Tyr Pro Ser Asn Glu Lys Thr Ser Arg Val Asn Trp
                325                 330                 335     
Ser Glu Ser Ser Thr Ala Glu His Ser Ser Lys Gly Asn Ser Glu Arg
            340                 345                 350         
Thr Pro Ser Phe Thr Ser Glu Trp Glu Glu Ile Asp Lys Ile Met Ser
        355                 360                 365             
Ser Ile Asp Val Gly Ile Asn Asn Glu Leu Lys Glu Met Asn Gly Glu
    370                 375                 380                 
Thr Thr Arg Pro Arg Cys Pro Val Gln Thr Val Gly Gln Trp Leu Glu
385                 390                 395                 400 
Ser Ile Gly Leu Pro Gln Tyr Glu Asn His Leu Met Ala Asn Gly Phe
                405                 410                 415     
Asp Asn Val Gln Phe Met Gly Ser Asn Val Met Glu Asp Gln Asp Leu
            420                 425                 430         
Leu Glu Ile Gly Ile Leu Asn Ser Gly His Arg Gln Arg Ile Leu Gln
        435                 440                 445             
Ala Ile Gln Leu Leu Pro Lys Met Arg Pro Ile Gly His Asp Gly Tyr
    450                 455                 460                 
His Pro Thr Ser Val Ala Glu Trp Leu Asp Ser Ile Glu Leu Gly Asp
465                 470                 475                 480 
Tyr Thr Lys Ala Phe Leu Ile Asn Gly Tyr Thr Ser Met Asp Leu Leu
                485                 490                 495     
Lys Lys Ile Trp Glu Val Glu Leu Ile Asn Val Leu Lys Ile Asn Leu
            500                 505                 510         
Ile Gly His Arg Lys Arg Ile Leu Ala Ser Leu Gly Asp Arg Leu His
        515                 520                 525             
Asp Asp Pro Pro Gln Lys Pro Pro Arg Ser Ile Thr Leu Arg Glu Pro
    530                 535                 540                 
Ser Gly Asn His Thr Pro Pro Gln Leu Ser Pro Ser Leu Ser Gln Ser
545                 550                 555                 560 
Thr Tyr Thr Thr Gly Gly Ser Leu Asp Val Pro His Ile Ile Met Gln
                565                 570                 575     
Gly Asp Ala Arg Arg Arg Arg Asn Glu Asn Tyr Phe Asp Asp Ile Pro
            580                 585                 590         
Arg Ser Lys Leu Glu Arg Gln Met Ala Gln Thr Gly Asp Trp Gly Glu
        595                 600                 605             
Pro Ser Ile Thr Leu Arg Pro Pro Asn Glu Ala Thr Ala Ser Thr Pro
    610                 615                 620                 
Val Gln Tyr Trp Gln His His Pro Glu Lys Leu Ile Phe Gln Ser Cys
625                 630                 635                 640 
Asp Tyr Lys Ala Phe Tyr Leu Gly Ser Met Leu Ile Lys Glu Leu Arg
                645                 650                 655     
Gly Thr Glu Ser Thr Gln Asp Ala Cys Ala Lys Met Arg Xaa Xaa Xaa
            660                 665                 670         
Xaa Lys Ser Thr Glu Gln Met Lys Lys Val Pro Thr Ile Ile Leu Ser
        675                 680                 685             
Val Ser Tyr Lys Gly Val Lys Phe Ile Asp Ala Thr Asn Lys Asn Ile
    690                 695                 700                 
Ile Ala Glu His Glu Ile Arg Asn Ile Ser Cys Ala Ala Gln Asp Pro
705                 710                 715                 720 
Glu Asp Leu Ser Thr Phe Ala Tyr Ile Thr Lys Asp Leu Lys Ser Asn
                725                 730                 735     
His His Tyr Cys His Val Phe Thr Ala Phe Asp Val Asn Leu Ala Tyr
            740                 745                 750         
Glu Ile Ile Leu Thr Leu Gly Gln Ala Phe Glu Val Ala Tyr Gln Leu
        755                 760                 765             
Ala Leu Gln Ala Arg Lys Gly Gly His Ser Ser Thr Leu Pro Glu Ser
    770                 775                 780                 
Phe Glu Asn Lys Pro Ser Lys Pro Ile Pro Lys Pro Arg Val Ser Ile
785                 790                 795                 800 
Arg Lys Ser Val Asp Leu Leu His Ala Ser His Thr Gly Gln Glu Pro
                805                 810                 815     
Ser Glu Arg His Thr Glu Glu Ala Leu Arg Lys Phe
            820                 825             


<210> 2150
<211> 415
<212> PRT
<213> Homo sapiens

<400> 2150
Met Val Phe Ala His Arg Met Asp Asn Ser Lys Pro His Leu Ile Ile
 1               5                  10                  15      
Pro Thr Leu Leu Val Pro Leu Gln Asn Arg Ser Cys Thr Glu Thr Ala
            20                  25                  30          
Thr Pro Leu Pro Ser Gln Tyr Leu Met Glu Leu Ser Glu Glu His Ser
        35                  40                  45              
Trp Met Ser Asn Gln Thr Asp Leu His Tyr Val Leu Lys Pro Gly Glu
    50                  55                  60                  
Val Ala Thr Ala Ser Ile Phe Phe Gly Ile Leu Trp Leu Phe Ser Ile
65                  70                  75                  80  
Phe Gly Asn Ser Leu Val Cys Leu Val Ile His Arg Ser Arg Arg Thr
                85                  90                  95      
Gln Ser Thr Thr Asn Tyr Phe Val Val Ser Met Ala Cys Ala Asp Leu
            100                 105                 110         
Leu Ile Ser Val Ala Ser Thr Pro Phe Val Leu Leu Gln Phe Thr Thr
        115                 120                 125             
Gly Arg Trp Thr Leu Gly Ser Ala Thr Cys Lys Val Val Arg Tyr Phe
    130                 135                 140                 
Gln Tyr Leu Thr Pro Gly Val Gln Ile Tyr Val Leu Leu Ser Ile Cys
145                 150                 155                 160 
Ile Asp Arg Phe Tyr Thr Ile Val Tyr Pro Leu Ser Phe Lys Val Ser
                165                 170                 175     
Arg Glu Lys Ala Lys Lys Met Ile Ala Ala Ser Trp Val Phe Asp Ala
            180                 185                 190         
Gly Phe Val Thr Pro Val Leu Phe Phe Tyr Gly Ser Asn Trp Asp Ser
        195                 200                 205             
His Cys Asn Tyr Phe Leu Pro Ser Ser Trp Glu Gly Thr Ala Tyr Thr
    210                 215                 220                 
Val Ile His Phe Leu Val Gly Phe Val Ile Pro Ser Val Leu Ile Ile
225                 230                 235                 240 
Leu Phe Tyr Gln Lys Val Ile Lys Tyr Ile Trp Arg Ile Gly Thr Asp
                245                 250                 255     
Gly Arg Thr Val Arg Arg Thr Met Asn Ile Val Pro Arg Thr Lys Val
            260                 265                 270         
Lys Thr Ile Lys Met Phe Leu Ile Leu Asn Leu Leu Phe Leu Leu Ser
        275                 280                 285             
Trp Leu Pro Phe His Val Ala Gln Leu Trp His Pro His Glu Gln Asp
    290                 295                 300                 
Tyr Lys Lys Ser Ser Leu Val Phe Thr Ala Ile Thr Trp Ile Ser Phe
305                 310                 315                 320 
Ser Ser Ser Ala Ser Lys Pro Thr Leu Tyr Ser Ile Tyr Asn Ala Asn
                325                 330                 335     
Phe Arg Arg Gly Met Lys Glu Thr Phe Cys Met Ser Ser Met Lys Cys
            340                 345                 350         
Tyr Arg Ser Asn Ala Tyr Thr Ile Thr Thr Ser Ser Arg Met Ala Lys
        355                 360                 365             
Lys Asn Tyr Val Gly Ile Ser Glu Ile Pro Ser Met Ala Lys Thr Ile
    370                 375                 380                 
Thr Lys Asp Ser Ile Tyr Asp Ser Phe Asp Arg Glu Ala Lys Glu Lys
385                 390                 395                 400 
Lys Leu Ala Trp Pro Ile Asn Ser Asn Pro Pro Asn Thr Phe Val
                405                 410                 415 


<210> 2151
<211> 432
<212> PRT
<213> Homo sapiens

<400> 2151
Met Ala Ala Pro Met Glu Val Ala Val Cys Thr Asp Ser Ala Ala Pro
 1               5                  10                  15      
Met Trp Ser Cys Ile Val Trp Glu Leu His Ser Gly Ala Asn Leu Leu
            20                  25                  30          
Thr Tyr Arg Gly Gly Gln Ala Gly Pro Arg Gly Leu Ala Leu Leu Asn
        35                  40                  45              
Gly Glu Tyr Leu Leu Ala Ala Gln Leu Gly Lys Asn Tyr Ile Ser Ala
    50                  55                  60                  
Trp Glu Leu Gln Arg Lys Asp Gln Leu Gln Gln Lys Ile Met Cys Pro
65                  70                  75                  80  
Gly Pro Val Thr Cys Leu Thr Ala Ser Pro Asn Gly Leu Tyr Val Leu
                85                  90                  95      
Ala Gly Val Ala Glu Ser Ile His Leu Trp Glu Val Ser Thr Gly Asn
            100                 105                 110         
Leu Leu Val Ile Leu Ser Arg His Tyr Gln Asp Val Ser Cys Leu Gln
        115                 120                 125             
Phe Thr Gly Asp Ser Ser His Phe Ile Ser Gly Gly Lys Asp Cys Leu
    130                 135                 140                 
Val Leu Val Trp Ser Leu Cys Ser Val Leu Gln Ala Asp Pro Ser Arg
145                 150                 155                 160 
Ile Pro Ala Pro Arg His Val Trp Ser His His Ala Leu Pro Ile Thr
                165                 170                 175     
Asp Leu His Cys Gly Phe Gly Gly Pro Leu Ala Arg Val Ala Thr Ser
            180                 185                 190         
Ser Leu Asp Gln Thr Val Lys Leu Trp Glu Val Ser Ser Gly Glu Leu
        195                 200                 205             
Leu Leu Ser Val Leu Phe Asp Val Ser Ile Met Ala Val Thr Met Asp
    210                 215                 220                 
Leu Ala Glu His His Met Phe Cys Gly Gly Ser Glu Gly Ser Ile Phe
225                 230                 235                 240 
Gln Val Asp Leu Phe Thr Trp Pro Gly Gln Arg Glu Arg Ser Phe His
                245                 250                 255     
Pro Glu Gln Asp Ala Gly Lys Val Phe Lys Gly His Arg Asn Gln Val
            260                 265                 270         
Thr Cys Leu Ser Val Ser Thr Asp Gly Ser Val Leu Leu Ser Gly Ser
        275                 280                 285             
His Asp Glu Thr Val Arg Leu Trp Asp Val Gln Ser Lys Gln Cys Ile
    290                 295                 300                 
Arg Thr Val Ala Leu Lys Gly Pro Val Thr Asn Ala Ala Ile Leu Leu
305                 310                 315                 320 
Ala Pro Val Ser Met Leu Ser Ser Asp Phe Arg Pro Ser Leu Pro Leu
                325                 330                 335     
Pro His Phe Asn Lys His Leu Leu Gly Ala Glu His Gly Asp Glu Pro
            340                 345                 350         
Arg His Gly Gly Leu Thr Leu Arg Leu Gly Leu His Gln Gln Gly Ser
        355                 360                 365             
Glu Pro Ser Tyr Leu Asp Arg Thr Glu Gln Leu Gln Ala Val Leu Cys
    370                 375                 380                 
Ser Thr Met Glu Lys Ser Val Leu Gly Gly Gln Asp Gln Leu Arg Val
385                 390                 395                 400 
Arg Val Thr Glu Leu Glu Asp Glu Val Arg Asn Leu Arg Lys Ile Asn
                405                 410                 415     
Arg Asp Leu Phe Asp Phe Ser Thr Arg Phe Ile Thr Arg Pro Ala Lys
            420                 425                 430         


<210> 2152
<211> 162
<212> PRT
<213> Homo sapiens

<400> 2152
Met Ala Pro Ile Lys Val Gly Asp Ala Ile Pro Ala Val Glu Val Phe
 1               5                  10                  15      
Glu Gly Glu Pro Gly Asn Lys Val Asn Leu Ala Glu Leu Phe Lys Gly
            20                  25                  30          
Lys Lys Gly Val Leu Phe Gly Val Pro Gly Ala Phe Thr Pro Gly Cys
        35                  40                  45              
Ser Lys Thr His Leu Pro Gly Phe Val Glu Gln Ala Glu Ala Leu Lys
    50                  55                  60                  
Ala Lys Gly Val Gln Val Val Ala Cys Leu Ser Val Asn Asp Ala Phe
65                  70                  75                  80  
Val Thr Gly Glu Trp Gly Arg Ala His Lys Ala Glu Gly Lys Val Arg
                85                  90                  95      
Leu Leu Ala Asp Pro Thr Gly Ala Phe Gly Lys Glu Thr Asp Leu Leu
            100                 105                 110         
Leu Asp Asp Ser Leu Val Ser Ile Phe Gly Asn Arg Arg Leu Lys Arg
        115                 120                 125             
Phe Ser Met Val Val Gln Asp Gly Ile Val Lys Ala Leu Asn Val Glu
    130                 135                 140                 
Pro Asp Gly Thr Gly Leu Thr Cys Ser Leu Ala Pro Asn Ile Ile Ser
145                 150                 155                 160 
Gln Leu
        


<210> 2153
<211> 1232
<212> PRT
<213> Homo sapiens

<400> 2153
Met Lys Glu Glu Val Lys Gly Ile Pro Val Arg Val Ala Leu Arg Cys
 1               5                  10                  15      
Arg Pro Leu Val Pro Lys Glu Ile Ser Glu Gly Cys Gln Met Cys Leu
            20                  25                  30          
Ser Phe Val Pro Gly Glu Pro Gln Val Val Val Gly Thr Asp Lys Ser
        35                  40                  45              
Phe Thr Tyr Asp Phe Val Phe Asp Pro Ser Thr Glu Gln Glu Glu Val
    50                  55                  60                  
Phe Asn Thr Ala Val Ala Pro Leu Ile Lys Gly Val Phe Lys Gly Tyr
65                  70                  75                  80  
Asn Ala Thr Val Leu Ala Tyr Gly Gln Thr Gly Ser Gly Lys Thr Tyr
                85                  90                  95      
Ser Met Gly Gly Ala Tyr Thr Ala Glu Gln Glu Asn Glu Pro Thr Val
            100                 105                 110         
Gly Val Ile Pro Arg Val Ile Gln Leu Leu Phe Lys Glu Ile Asp Lys
        115                 120                 125             
Lys Ser Asp Phe Glu Phe Thr Leu Lys Val Ser Tyr Leu Glu Ile Tyr
    130                 135                 140                 
Asn Glu Glu Ile Leu Asp Leu Leu Cys Pro Ser Arg Glu Lys Ala Gln
145                 150                 155                 160 
Ile Asn Ile Arg Glu Asp Pro Lys Glu Gly Ile Lys Ile Val Gly Leu
                165                 170                 175     
Thr Glu Lys Thr Val Leu Val Ala Leu Asp Thr Val Ser Cys Leu Glu
            180                 185                 190         
Gln Gly Asn Asn Ser Arg Thr Val Ala Ser Thr Ala Met Asn Ser Gln
        195                 200                 205             
Ser Ser Arg Ser His Ala Ile Phe Thr Ile Ser Leu Glu Gln Arg Lys
    210                 215                 220                 
Lys Ser Asp Lys Asn Ser Ser Phe Arg Ser Lys Leu His Leu Val Asp
225                 230                 235                 240 
Leu Ala Gly Ser Glu Arg Gln Lys Lys Thr Lys Ala Glu Gly Asp Arg
                245                 250                 255     
Leu Lys Glu Gly Ile Asn Ile Asn Arg Gly Leu Leu Cys Leu Gly Asn
            260                 265                 270         
Val Ile Ser Ala Leu Gly Asp Asp Lys Lys Gly Gly Phe Val Pro Tyr
        275                 280                 285             
Arg Asp Ser Lys Leu Thr Arg Leu Leu Gln Asp Ser Leu Gly Gly Asn
    290                 295                 300                 
Ser His Thr Leu Met Ile Ala Cys Val Ser Pro Ala Asp Ser Asn Leu
305                 310                 315                 320 
Glu Glu Thr Leu Asn Thr Leu Arg Tyr Ala Asp Arg Ala Arg Lys Ile
                325                 330                 335     
Lys Asn Lys Pro Ile Val Asn Ile Asp Pro Gln Thr Ala Glu Leu Asn
            340                 345                 350         
His Leu Lys Gln Gln Val Gln Gln Leu Gln Val Leu Leu Leu Gln Ala
        355                 360                 365             
His Gly Gly Thr Leu Pro Gly Ser Ile Thr Val Glu Pro Ser Glu Asn
    370                 375                 380                 
Leu Gln Ser Leu Met Glu Lys Asn Gln Ser Leu Val Glu Glu Asn Glu
385                 390                 395                 400 
Lys Leu Ser Arg Gly Leu Ser Glu Ala Ala Gly Gln Thr Ala Gln Met
                405                 410                 415     
Leu Glu Arg Ile Ile Leu Thr Glu Gln Ala Asn Glu Lys Met Asn Ala
            420                 425                 430         
Lys Leu Glu Glu Leu Arg Gln His Ala Ala Cys Lys Leu Asp Leu Gln
        435                 440                 445             
Lys Leu Val Glu Thr Leu Glu Asp Gln Glu Leu Lys Glu Asn Val Glu
    450                 455                 460                 
Ile Ile Cys Asn Leu Gln Gln Leu Ile Thr Gln Leu Ser Asp Glu Thr
465                 470                 475                 480 
Val Ala Cys Met Ala Ala Ala Ile Asp Thr Ala Val Glu Gln Glu Ala
                485                 490                 495     
Gln Val Glu Thr Ser Pro Glu Thr Ser Arg Ser Ser Asp Ala Phe Thr
            500                 505                 510         
Thr Gln His Ala Leu Arg Gln Ala Gln Met Ser Lys Glu Leu Val Glu
        515                 520                 525             
Leu Asn Lys Ala Leu Ala Leu Lys Glu Ala Leu Ala Arg Lys Met Thr
    530                 535                 540                 
Gln Asn Asp Ser Gln Leu Gln Pro Ile Gln Tyr Gln Tyr Gln Asp Asn
545                 550                 555                 560 
Ile Lys Glu Leu Glu Leu Glu Val Ile Asn Leu Gln Lys Glu Lys Glu
                565                 570                 575     
Glu Leu Val Leu Glu Leu Gln Thr Ala Lys Lys Asp Ala Asn Gln Ala
            580                 585                 590         
Lys Leu Ser Glu Arg Arg Arg Lys Arg Leu Gln Glu Leu Glu Gly Gln
        595                 600                 605             
Ile Ala Asp Leu Lys Lys Lys Leu Asn Glu Gln Ser Lys Leu Leu Lys
    610                 615                 620                 
Leu Lys Glu Ser Thr Glu Arg Thr Val Ser Lys Leu Asn Gln Glu Ile
625                 630                 635                 640 
Arg Met Met Lys Asn Gln Arg Val Gln Leu Met Arg Gln Met Lys Glu
                645                 650                 655     
Asp Ala Glu Lys Phe Arg Gln Trp Lys Gln Lys Lys Asp Lys Glu Val
            660                 665                 670         
Ile Gln Leu Lys Glu Arg Asp Arg Lys Arg Gln Tyr Glu Leu Leu Lys
        675                 680                 685             
Leu Glu Arg Asn Phe Gln Lys Gln Ser Asn Val Leu Arg Arg Lys Thr
    690                 695                 700                 
Glu Glu Ala Ala Ala Ala Asn Lys Arg Leu Lys Asp Ala Leu Gln Lys
705                 710                 715                 720 
Gln Arg Glu Val Ala Asp Lys Arg Lys Glu Thr Gln Ser Arg Gly Met
                725                 730                 735     
Glu Gly Thr Ala Ala Arg Val Lys Asn Trp Leu Gly Asn Glu Ile Glu
            740                 745                 750         
Val Met Val Ser Thr Glu Glu Ala Lys Arg His Leu Asn Asp Leu Leu
        755                 760                 765             
Glu Asp Arg Lys Ile Leu Ala Gln Asp Val Ala Gln Leu Lys Glu Lys
    770                 775                 780                 
Lys Glu Ser Gly Glu Asn Pro Pro Pro Lys Leu Arg Arg Arg Thr Phe
785                 790                 795                 800 
Ser Leu Thr Glu Val Arg Gly Gln Val Ser Glu Ser Glu Asp Ser Ile
                805                 810                 815     
Thr Lys Gln Ile Glu Ser Leu Glu Thr Glu Met Glu Phe Arg Ser Ala
            820                 825                 830         
Gln Ile Ala Asp Leu Gln Gln Lys Leu Leu Asp Ala Glu Ser Glu Asp
        835                 840                 845             
Arg Pro Lys Gln Arg Trp Glu Asn Ile Ala Thr Ile Leu Glu Ala Lys
    850                 855                 860                 
Cys Ala Leu Lys Tyr Leu Ile Gly Glu Leu Val Ser Ser Lys Ile Gln
865                 870                 875                 880 
Val Ser Lys Leu Glu Ser Ser Leu Lys Gln Ser Lys Thr Ser Cys Ala
                885                 890                 895     
Asp Met Gln Lys Met Leu Phe Glu Glu Arg Asn His Phe Ala Glu Ile
            900                 905                 910         
Glu Thr Glu Leu Gln Ala Glu Leu Val Arg Met Glu Gln Gln His Gln
        915                 920                 925             
Glu Lys Val Leu Tyr Leu Leu Ser Gln Leu Gln Gln Ser Gln Met Ala
    930                 935                 940                 
Glu Lys Gln Leu Glu Glu Ser Val Ser Glu Lys Glu Gln Gln Leu Leu
945                 950                 955                 960 
Ser Thr Leu Lys Cys Gln Asp Glu Glu Leu Glu Lys Met Arg Glu Val
                965                 970                 975     
Cys Glu Gln Asn Gln Gln Leu Leu Arg Glu Asn Glu Ile Ile Lys Gln
            980                 985                 990         
Lys Leu Thr Leu Leu Gln Val Ala Ser Arg Gln Lys His Leu Pro Lys
        995                 1000                1005            
Asp Thr Leu Leu Ser Pro Asp Ser Ser Phe Glu Tyr Val Pro Pro Lys
    1010                1015                1020                
Pro Lys Pro Ser Arg Val Lys Glu Lys Phe Leu Glu Gln Ser Met Asp
1025                1030                1035                1040
Ile Glu Asp Leu Lys Tyr Cys Ser Glu His Ser Val Asn Glu His Glu
                1045                1050                1055    
Asp Gly Asp Gly Asp Asp Asp Glu Gly Asp Asp Glu Glu Trp Lys Pro
            1060                1065                1070        
Thr Lys Leu Val Lys Val Ser Arg Lys Asn Ile Gln Gly Cys Ser Cys
        1075                1080                1085            
Lys Gly Trp Cys Gly Asn Lys Gln Cys Gly Cys Arg Lys Gln Lys Ser
    1090                1095                1100                
Asp Cys Gly Val Asp Cys Cys Cys Asp Pro Thr Lys Cys Arg Asn Arg
1105                1110                1115                1120
Gln Gln Gly Lys Asp Ser Leu Gly Thr Val Glu Arg Thr Gln Asp Ser
                1125                1130                1135    
Glu Gly Ser Phe Lys Leu Glu Asp Pro Thr Glu Val Thr Pro Gly Leu
            1140                1145                1150        
Ser Phe Phe Asn Pro Val Cys Ala Thr Pro Asn Ser Lys Ile Leu Lys
        1155                1160                1165            
Glu Met Cys Asp Val Glu Gln Val Leu Ser Lys Lys Thr Pro Pro Ala
    1170                1175                1180                
Pro Ser Pro Phe Asp Leu Pro Glu Leu Lys His Val Ala Thr Glu Tyr
1185                1190                1195                1200
Gln Glu Asn Lys Ala Pro Gly Lys Lys Lys Lys Arg Ala Leu Ala Ser
                1205                1210                1215    
Asn Thr Ser Phe Phe Ser Gly Cys Ser Pro Ile Glu Glu Glu Ala His
            1220                1225                1230        


<210> 2154
<211> 1139
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 422, 423, 424, 425, 426, 427, 428, 429, 430, 431
<223> Xaa = Any Amino Acid

<400> 2154
Met Met Asn His Val Tyr Arg Glu Arg Phe Pro Lys Ala Thr Ala Gln
 1               5                  10                  15      
Met Glu Gly Arg Leu Gln Glu Phe Leu Thr Ala Tyr Ala Pro Gly Ala
            20                  25                  30          
Arg Leu Ala Leu Ala Asp Gly Val Leu Gly Phe Ile His His Gln Ile
        35                  40                  45              
Val Glu Leu Ala Arg Asp Cys Leu Ala Lys Ser Gly Glu Asn Leu Val
    50                  55                  60                  
Thr Ser Arg Tyr Phe Leu Glu Met Gln Glu Lys Leu Glu Arg Leu Leu
65                  70                  75                  80  
Gln Asp Ala His Glu Arg Ser Asp Ser Glu Glu Val Ser Phe Ile Val
                85                  90                  95      
Gln Leu Val Arg Lys Leu Leu Ile Ile Ile Ser Arg Pro Ala Arg Leu
            100                 105                 110         
Leu Glu Cys Leu Glu Phe Asp Pro Glu Glu Phe Tyr His Leu Leu Glu
        115                 120                 125             
Ala Ala Glu Gly His Ala Arg Glu Gly Gln Gly Ile Lys Thr Asp Leu
    130                 135                 140                 
Pro Gln Tyr Ile Ile Gly Gln Leu Gly Leu Ala Lys Asp Pro Leu Glu
145                 150                 155                 160 
Glu Met Val Pro Leu Ser His Leu Glu Glu Glu Gln Pro Pro Ala Pro
                165                 170                 175     
Glu Ser Pro Glu Ser Arg Ala Leu Val Gly Gln Ser Arg Arg Lys Pro
            180                 185                 190         
Cys Glu Ser Asp Phe Glu Thr Ile Lys Leu Ile Ser Asn Gly Ala Tyr
        195                 200                 205             
Gly Ala Val Tyr Leu Val Arg His Arg Asp Thr Arg Gln Arg Phe Ala
    210                 215                 220                 
Ile Lys Lys Ile Asn Lys Gln Asn Leu Ile Leu Arg Asn Gln Ile Gln
225                 230                 235                 240 
Gln Val Phe Val Glu Arg Asp Ile Leu Thr Phe Ala Glu Asn Pro Phe
                245                 250                 255     
Val Val Ser Met Phe Cys Ser Phe Glu Thr Arg Arg His Leu Cys Met
            260                 265                 270         
Val Met Glu Tyr Val Glu Gly Gly Asp Cys Ala Thr Leu Leu Lys Asn
        275                 280                 285             
Met Gly Pro Leu Pro Val Asp Met Ala Arg Leu Tyr Phe Ala Glu Thr
    290                 295                 300                 
Val Leu Ala Leu Glu Tyr Leu His Asn Tyr Gly Ile Val His Arg Asp
305                 310                 315                 320 
Leu Lys Pro Asp Asn Leu Leu Ile Thr Ser Leu Gly His Ile Lys Leu
                325                 330                 335     
Thr Asp Phe Gly Leu Ser Lys Ile Gly Leu Met Ser Met Ala Thr Asn
            340                 345                 350         
Leu Tyr Glu Gly His Ile Glu Lys Asp Ala Arg Glu Phe Ile Asp Lys
        355                 360                 365             
Gln Val Cys Gly Thr Pro Glu Tyr Ile Ala Pro Glu Val Ile Phe Arg
    370                 375                 380                 
Gln Gly Tyr Gly Lys Pro Val Asp Trp Trp Ala Met Gly Val Val Leu
385                 390                 395                 400 
Tyr Glu Phe Leu Val Gly Cys Val Pro Phe Phe Gly Asp Thr Pro Glu
                405                 410                 415     
Glu Leu Phe Gly Gln Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly
            420                 425                 430         
Asp Glu Ala Leu Pro Ala Asp Ala Gln Asp Leu Ile Thr Arg Leu Leu
        435                 440                 445             
Arg Gln Ser Pro Leu Asp Arg Leu Gly Thr Gly Gly Thr His Glu Val
    450                 455                 460                 
Lys Gln His Pro Phe Phe Leu Ala Leu Asp Trp Ala Gly Leu Leu Arg
465                 470                 475                 480 
His Lys Ala Glu Phe Val Pro Gln Leu Glu Ala Glu Asp Asp Thr Ser
                485                 490                 495     
Tyr Phe Asp Thr Arg Ser Glu Arg Tyr Arg His Leu Gly Ser Glu Asp
            500                 505                 510         
Asp Glu Thr Asn Asp Glu Glu Ser Ser Thr Glu Ile Pro Gln Phe Ser
        515                 520                 525             
Ser Cys Ser His Arg Phe Ser Lys Val Tyr Ser Ser Ser Glu Phe Leu
    530                 535                 540                 
Ala Val Gln Pro Thr Pro Thr Phe Ala Glu Arg Ser Phe Ser Glu Asp
545                 550                 555                 560 
Arg Glu Glu Gly Trp Glu Arg Ser Glu Val Asp Tyr Gly Arg Arg Leu
                565                 570                 575     
Ser Ala Asp Ile Arg Leu Arg Ser Trp Thr Ser Ser Gly Ser Ser Cys
            580                 585                 590         
Gln Ser Ser Ser Ser Gln Pro Glu Arg Gly Pro Ser Pro Ser Leu Leu
        595                 600                 605             
Asn Thr Ile Ser Leu Asp Thr Met Pro Lys Phe Ala Phe Ser Ser Glu
    610                 615                 620                 
Asp Glu Gly Val Gly Pro Gly Pro Ala Gly Pro Lys Arg Pro Val Phe
625                 630                 635                 640 
Ile Leu Gly Glu Pro Asp Pro Pro Pro Ala Ala Thr Pro Val Met Pro
                645                 650                 655     
Lys Pro Ser Ser Leu Ser Ala Asp Thr Ala Ala Leu Ser His Ala Arg
            660                 665                 670         
Leu Arg Ser Asn Ser Ile Gly Ala Arg His Ser Thr Pro Arg Pro Leu
        675                 680                 685             
Asp Ala Gly Arg Gly Arg Arg Leu Gly Gly Pro Arg Asp Pro Ala Pro
    690                 695                 700                 
Glu Lys Ser Arg Ala Ser Ser Ser Gly Gly Ser Gly Gly Gly Ser Gly
705                 710                 715                 720 
Gly Arg Val Pro Lys Ser Ala Ser Val Ser Ala Leu Ser Leu Ile Ile
                725                 730                 735     
Thr Ala Asp Asp Gly Ser Gly Gly Pro Leu Met Ser Pro Leu Ser Pro
            740                 745                 750         
Arg Ser Leu Ser Ser Asn Pro Ser Ser Arg Asp Ser Ser Pro Ser Arg
        755                 760                 765             
Asp Pro Ser Pro Val Cys Gly Ser Leu Arg Pro Pro Ile Val Ile His
    770                 775                 780                 
Ser Ser Gly Lys Lys Tyr Gly Phe Ser Leu Arg Ala Ile Arg Val Tyr
785                 790                 795                 800 
Met Gly Asp Ser Asp Val Tyr Thr Val His His Val Val Trp Ser Val
                805                 810                 815     
Glu Asp Gly Ser Pro Ala Gln Glu Ala Gly Leu Arg Ala Gly Asp Leu
            820                 825                 830         
Ile Thr His Ile Asn Gly Glu Ser Val Leu Gly Leu Val His Met Asp
        835                 840                 845             
Val Val Glu Leu Leu Leu Lys Ser Gly Asn Lys Ile Ser Leu Arg Thr
    850                 855                 860                 
Thr Ala Leu Glu Asn Thr Ser Ile Lys Val Gly Pro Ala Arg Lys Asn
865                 870                 875                 880 
Val Ala Lys Gly Arg Met Ala Arg Arg Ser Lys Arg Ser Arg Arg Arg
                885                 890                 895     
Glu Thr Gln Asp Arg Arg Lys Ser Leu Phe Lys Lys Ile Ser Lys Gln
            900                 905                 910         
Thr Ser Val Leu His Thr Ser Arg Ser Phe Ser Ser Gly Leu His His
        915                 920                 925             
Ser Leu Ser Ser Ser Glu Ser Leu Pro Gly Ser Pro Thr His Ser Leu
    930                 935                 940                 
Ser Pro Ser Pro Thr Thr Pro Cys Arg Ser Pro Ala Pro Asp Val Pro
945                 950                 955                 960 
Ala Asp Thr Thr Ala Ser Pro Pro Ser Ala Ser Pro Ser Ser Ser Ser
                965                 970                 975     
Pro Ala Ser Pro Ala Ala Ala Gly His Thr Arg Pro Ser Ser Leu His
            980                 985                 990         
Gly Leu Ala Ala Lys Leu Gly Pro Pro Arg Pro Lys Thr Gly Arg Arg
        995                 1000                1005            
Lys Ser Thr Ser Ser Ile Pro Pro Ser Pro Leu Ala Cys Pro Pro Ile
    1010                1015                1020                
Ser Ala Pro Pro Pro Arg Ser Pro Ser Pro Leu Pro Gly His Pro Pro
1025                1030                1035                1040
Ala Pro Ala Arg Ser Pro Arg Leu Arg Arg Gly Gln Ser Ala Asp Lys
                1045                1050                1055    
Leu Gly Thr Gly Glu Arg Leu Asp Gly Glu Ala Gly Arg Arg Thr Arg
            1060                1065                1070        
Gly Pro Glu Ala Glu Leu Val Val Met Arg Arg Leu His Leu Ser Glu
        1075                1080                1085            
Arg Arg Asp Ser Phe Lys Lys Gln Glu Ala Val Gln Glu Val Ser Phe
    1090                1095                1100                
Asp Glu Pro Gln Glu Glu Ala Thr Gly Leu Pro Thr Ser Val Pro Gln
1105                1110                1115                1120
Ile Ala Val Glu Gly Glu Glu Ala Val Pro Val Ala Leu Gly Pro Thr
                1125                1130                1135    
Gly Arg Asp
            


<210> 2155
<211> 966
<212> PRT
<213> Homo sapiens

<400> 2155
Met Cys Pro Leu Ala His Pro Ala Gln Asp Leu Pro Leu Leu Pro Ser
 1               5                  10                  15      
Gln Leu Ser Leu Asp Pro Ser Gly Pro Glu Trp Asp Cys Pro Leu Gly
            20                  25                  30          
Ser Lys Asp Leu Glu Glu Glu Gly Pro Trp Gly Gly Gly Ser Gly Leu
        35                  40                  45              
Pro Pro Thr Gly Cys Phe Pro Gly Ser Trp Arg Gln Asp Val Gly Leu
    50                  55                  60                  
Asp Cys Lys Gly Ser Pro Glu Gly Ala Glu Ala Arg Ala Trp Thr Val
65                  70                  75                  80  
Tyr Tyr Tyr Ser Leu Leu Gln Ser Cys Leu Gln Gln Ala Gly Leu Pro
                85                  90                  95      
Glu Thr Gln Asp Arg Gly Gln Val Pro Arg Thr Gly Cys Pro Gly Ala
            100                 105                 110         
Glu Val Thr Leu Cys Val Leu Gly Ser Pro Ser Thr Phe Leu Pro Val
        115                 120                 125             
Leu Leu Glu Gly Gly Val Gln Ser Pro Gly Asn Met Leu Leu Cys Leu
    130                 135                 140                 
Ser Pro Ala Trp Leu Met Lys Val Pro Ala Pro Gly Gln Pro Gly Glu
145                 150                 155                 160 
Ala Ala Leu Leu Val Ser Lys Ala Val Ser Phe His Pro Gly Gly Leu
                165                 170                 175     
Thr Phe Leu Asp Asp Phe Val Pro Pro Arg Arg Ala Thr Tyr Phe Leu
            180                 185                 190         
Ala Gly Leu Gly Leu Gly Pro Gly Arg Gly Arg Glu Ala Ala Glu Leu
        195                 200                 205             
Ala Arg Asp Leu Thr Cys Pro Thr Gly Ala Ser Ala Glu Leu Ala Arg
    210                 215                 220                 
Leu Leu Glu Asp Arg Leu Leu Thr Arg Gln Leu Leu Ala Gln Gln Gly
225                 230                 235                 240 
Gly Val Ala Val Pro Ala Thr Leu Ala Phe Thr Tyr Lys Pro Pro Gly
                245                 250                 255     
Leu Leu Arg Gly Gly Asp Ala Ser Leu Gly Leu Arg Leu Val Glu Leu
            260                 265                 270         
Ser Gly Lys Glu Gly Gln Glu Thr Leu Val Lys Glu Glu Val Glu Ala
        275                 280                 285             
Phe Leu Arg Ser Glu Ala Leu Gly Asp Ile Leu Gln Val Ala Val Lys
    290                 295                 300                 
Leu Ser Gly Trp Arg Trp Arg Gly Arg Gln Ala Trp Arg Leu His Pro
305                 310                 315                 320 
Arg Ala Glu Leu Gly Ala Val Val Asp Thr Val Leu Ala Leu Leu Glu
                325                 330                 335     
Lys Leu Glu Glu Glu Glu Ser Val Leu Val Glu Ala Val Tyr Pro Pro
            340                 345                 350         
Ala Gln Leu Pro Cys Ser Asp Gly Pro Ser Pro Gly Pro Gly Leu Ala
        355                 360                 365             
Val Arg Ile Cys Ala Val Val Cys Arg Thr Gln Gly Asp Arg Pro Leu
    370                 375                 380                 
Leu Ser Lys Val Val Cys Gly Val Gly Arg Gly Asp Arg Pro Leu Arg
385                 390                 395                 400 
His His Asn Ser Leu Pro Arg Thr Leu Glu Val Ala Leu Ala Gln Cys
                405                 410                 415     
Gly Leu Gly Glu Glu Ala Gln Val Ala Ala Val Arg Gln Arg Val Lys
            420                 425                 430         
Ala Ala Ala Glu Ala Ala Leu Ala Ala Val Leu Ala Leu Glu Ala Gly
        435                 440                 445             
Leu Ser Ala Glu Gln Arg Gly Gly Arg Arg Ala His Thr Asp Phe Leu
    450                 455                 460                 
Gly Val Asp Phe Ala Leu Thr Ala Ala Gly Gly Val Leu Thr Pro Val
465                 470                 475                 480 
Ala Leu Glu Leu Asn Gly Gly Leu Cys Leu Glu Ala Cys Gly Ala Leu
                485                 490                 495     
Glu Gly Leu Trp Ala Ala Pro Arg Leu Gly Pro Ala Ala Asp Glu Ala
            500                 505                 510         
Val Ala Ala Pro Leu Val Glu Thr Met Leu Arg Arg Ser Ala Arg Cys
        515                 520                 525             
Leu Met Glu Gly Lys Gln Leu Leu Val Val Gly Ala Gly Gly Val Ser
    530                 535                 540                 
Lys Lys Phe Val Trp Glu Ala Ala Arg Asp Tyr Gly Leu Gln Leu His
545                 550                 555                 560 
Leu Val Glu Ser Asp Pro Asn His Phe Ala Ser Gln Leu Val Gln Thr
                565                 570                 575     
Phe Ile His Phe Asp Met Thr Glu His Arg Arg Asp Glu Glu Asn Ala
            580                 585                 590         
Arg Leu Leu Ala Glu Leu Val Arg Ala Arg Gly Leu Lys Leu Asp Gly
        595                 600                 605             
Cys Phe Ser Tyr Trp Asp Asp Cys Leu Val Leu Thr Ala Leu Leu Cys
    610                 615                 620                 
Gln Glu Leu Gly Leu Pro Cys Ser Ser Pro Ala Ala Met Arg Leu Ala
625                 630                 635                 640 
Lys Gln Lys Ser Leu Thr Gln Leu His Leu Leu His His His Gly Pro
                645                 650                 655     
Pro Trp Pro Ala Pro Ser Leu His Ala Val Pro Cys Cys Pro Leu Glu
            660                 665                 670         
Ser Glu Ala Asp Val Glu Arg Ala Val His Gln Val Pro Leu Pro Gly
        675                 680                 685             
Val Met Lys Leu Glu Phe Gly Ala Gly Ala Val Gly Val Arg Leu Val
    690                 695                 700                 
Glu Asp Ala Pro Gln Cys His Glu His Phe Ser Arg Ile Thr Arg Asp
705                 710                 715                 720 
Leu Gln Gly Glu Ala Asp His Pro Gly Ile Gly Leu Gly Trp Gly Asn
                725                 730                 735     
Ala Met Leu Leu Met Glu Phe Val Glu Gly Thr Glu His Asp Val Asp
            740                 745                 750         
Leu Val Leu Phe Gly Gly Arg Leu Leu Ala Ala Phe Val Ser Asp Asn
        755                 760                 765             
Gly Pro Thr Arg Leu Pro Gly Phe Thr Glu Thr Ala Ala Cys Met Pro
    770                 775                 780                 
Thr Gly Leu Ala Pro Glu Gln Glu Ala Gln Met Val Gln Ala Ala Phe
785                 790                 795                 800 
Arg Cys Cys Leu Gly Cys Gly Leu Leu Asp Gly Val Phe Asn Val Glu
                805                 810                 815     
Leu Lys Leu Thr Gly Ala Gly Pro Arg Leu Ile Glu Ile Asn Pro Arg
            820                 825                 830         
Met Gly Gly Phe Tyr Leu Arg Asp Trp Ile Leu Glu Leu Tyr Gly Val
        835                 840                 845             
Asp Leu Leu Leu Ala Ala Val Met Val Ala Cys Gly Leu Arg Pro Ala
    850                 855                 860                 
Leu Pro Thr Arg Pro Arg Ala Arg Gly His Leu Val Gly Val Met Cys
865                 870                 875                 880 
Leu Val Ser Gln His Leu Gln Ala Leu Ser Ser Thr Ala Ser Arg Glu
                885                 890                 895     
Thr Leu Gln Ala Leu His Asp Arg Gly Leu Leu Arg Leu Asn Leu Leu
            900                 905                 910         
Glu Glu Ala Leu Val Pro Gly Glu Tyr Glu Glu Pro Tyr Cys Ser Val
        915                 920                 925             
Ala Cys Ala Gly Pro Ser Pro Thr Glu Ala Arg Leu Arg Leu Leu Gly
    930                 935                 940                 
Leu Cys Gln Gly Leu Gly Ile Asp Gly Pro Ser Tyr Pro Val Ala His
945                 950                 955                 960 
Phe Leu Ser His Phe Lys
                965     


<210> 2156
<211> 210
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 13, 14, 15, 16, 17
<223> Xaa = Any Amino Acid

<400> 2156
Met Pro Pro Tyr Thr Val Val Tyr Phe Pro Val Arg Xaa Xaa Xaa Xaa
 1               5                  10                  15      
Xaa Leu Arg Met Leu Leu Ala Asp Gln Gly Gln Ser Trp Lys Glu Glu
            20                  25                  30          
Val Val Thr Val Glu Thr Trp Gln Glu Gly Ser Leu Lys Ala Ser Cys
        35                  40                  45              
Leu Tyr Gly Gln Leu Pro Lys Phe Gln Asp Gly Asp Leu Thr Leu Tyr
    50                  55                  60                  
Gln Ser Asn Thr Ile Leu Arg His Leu Gly Arg Thr Leu Gly Leu Tyr
65                  70                  75                  80  
Gly Lys Asp Gln Gln Glu Ala Ala Leu Val Asp Met Val Asn Asp Gly
                85                  90                  95      
Val Glu Asp Leu Arg Cys Lys Tyr Ile Ser Leu Ile Tyr Thr Asn Tyr
            100                 105                 110         
Glu Ala Gly Lys Asp Asp Tyr Val Lys Ala Leu Pro Gly Gln Leu Lys
        115                 120                 125             
Pro Phe Glu Thr Leu Leu Ser Gln Asn Gln Gly Gly Lys Thr Phe Ile
    130                 135                 140                 
Val Gly Asp Gln Ile Ser Phe Ala Asp Tyr Asn Leu Leu Asp Leu Leu
145                 150                 155                 160 
Leu Ile His Glu Val Leu Ala Pro Gly Cys Leu Asp Ala Phe Pro Leu
                165                 170                 175     
Leu Ser Ala Tyr Val Gly Arg Leu Ser Ala Arg Pro Lys Leu Lys Ala
            180                 185                 190         
Phe Leu Ala Ser Pro Glu Tyr Val Asn Leu Pro Ile Asn Gly Asn Gly
        195                 200                 205             
Lys Gln
    210 


<210> 2157
<211> 563
<212> PRT
<213> Homo sapiens

<400> 2157
Met Ile Lys Arg Arg Ala His Pro Gly Ala Gly Gly Asp Arg Thr Arg
 1               5                  10                  15      
Pro Arg Arg Arg Arg Ser Thr Glu Ser Trp Ile Glu Arg Cys Leu Asn
            20                  25                  30          
Glu Ser Glu Asn Lys Arg Tyr Ser Ser His Thr Ser Leu Gly Asn Val
        35                  40                  45              
Ser Asn Asp Glu Asn Glu Glu Lys Glu Asn Asn Arg Ala Ser Lys Pro
    50                  55                  60                  
His Ser Thr Pro Ala Thr Leu Gln Trp Leu Glu Glu Asn Tyr Glu Ile
65                  70                  75                  80  
Ala Glu Gly Val Cys Ile Pro Arg Ser Ala Leu Tyr Met His Tyr Leu
                85                  90                  95      
Asp Phe Cys Glu Lys Asn Asp Thr Gln Pro Val Asn Ala Ala Ser Phe
            100                 105                 110         
Gly Lys Ile Ile Arg Gln Gln Phe Pro Gln Leu Thr Thr Arg Arg Leu
        115                 120                 125             
Gly Thr Arg Gly Gln Ser Lys Tyr His Tyr Tyr Gly Ile Ala Val Lys
    130                 135                 140                 
Glu Ser Ser Gln Tyr Tyr Asp Val Met Tyr Ser Lys Lys Gly Ala Ala
145                 150                 155                 160 
Trp Val Ser Glu Thr Gly Lys Lys Glu Val Ser Lys Gln Thr Val Ala
                165                 170                 175     
Tyr Ser Pro Arg Ser Lys Leu Gly Thr Leu Leu Pro Glu Phe Pro Asn
            180                 185                 190         
Val Lys Asp Leu Asn Leu Pro Ala Ser Leu Pro Glu Glu Lys Val Ser
        195                 200                 205             
Thr Phe Ile Met Met Tyr Arg Thr His Cys Gln Arg Ile Leu Asp Thr
    210                 215                 220                 
Val Ile Arg Ala Asn Phe Asp Glu Val Gln Ser Phe Leu Leu His Phe
225                 230                 235                 240 
Trp Gln Gly Met Pro Pro His Met Leu Pro Val Leu Gly Ser Ser Thr
                245                 250                 255     
Val Val Asn Ile Val Gly Val Cys Asp Ser Ile Leu Tyr Lys Ala Ile
            260                 265                 270         
Ser Gly Val Leu Met Pro Thr Val Leu Gln Ala Leu Pro Asp Ser Leu
        275                 280                 285             
Thr Gln Val Ile Arg Lys Phe Ala Lys Gln Leu Asp Glu Trp Leu Lys
    290                 295                 300                 
Val Ala Leu His Asp Leu Pro Glu Asn Leu Arg Asn Ile Lys Phe Glu
305                 310                 315                 320 
Leu Ser Arg Arg Phe Ser Gln Ile Leu Arg Arg Gln Thr Ser Leu Asn
                325                 330                 335     
His Leu Cys Gln Ala Ser Arg Thr Val Ile His Ser Ala Asp Ile Thr
            340                 345                 350         
Phe Gln Met Leu Glu Asp Trp Arg Asn Val Asp Leu Asn Ser Ile Thr
        355                 360                 365             
Lys Gln Thr Leu Tyr Thr Met Glu Asp Ser Arg Asp Glu His Arg Lys
    370                 375                 380                 
Leu Ile Thr Gln Leu Tyr Gln Glu Phe Asp His Leu Leu Glu Glu Gln
385                 390                 395                 400 
Ser Pro Ile Glu Ser Tyr Ile Glu Trp Leu Asp Thr Met Val Asp Arg
                405                 410                 415     
Cys Val Val Lys Val Ala Ala Lys Arg Gln Gly Ser Leu Lys Lys Val
            420                 425                 430         
Ala Gln Gln Phe Leu Leu Met Trp Ser Cys Phe Gly Thr Arg Val Ile
        435                 440                 445             
Arg Asp Met Thr Leu His Ser Ala Pro Ser Phe Gly Ser Phe His Leu
    450                 455                 460                 
Ile His Leu Met Phe Asp Asp Tyr Val Leu Tyr Leu Leu Glu Ser Leu
465                 470                 475                 480 
His Cys Gln Glu Arg Ala Asn Glu Leu Met Arg Ala Met Lys Gly Glu
                485                 490                 495     
Gly Ser Thr Ala Glu Val Arg Glu Glu Ile Ile Leu Thr Glu Ala Ala
            500                 505                 510         
Ala Pro Thr Pro Ser Pro Val Pro Ser Phe Ser Pro Ala Lys Ser Ala
        515                 520                 525             
Thr Ser Val Glu Val Pro Pro Pro Ser Ser Pro Val Ser Asn Pro Ser
    530                 535                 540                 
Pro Glu Tyr Thr Gly Leu Ser Thr Thr Gly Asn Gly Lys Ser Phe Lys
545                 550                 555                 560 
Asn Phe Gly
            


<210> 2158
<211> 602
<212> PRT
<213> Homo sapiens

<400> 2158
Met Pro Ser Ala Lys Gln Arg Gly Ser Lys Gly Gly His Gly Ala Ala
 1               5                  10                  15      
Ser Pro Ser Glu Lys Gly Ala His Pro Ser Gly Gly Ala Asp Asp Val
            20                  25                  30          
Ala Lys Lys Pro Pro Pro Ala Pro Gln Gln Pro Pro Pro Pro Pro Ala
        35                  40                  45              
Pro His Pro Gln Gln His Pro Gln Gln His Pro Gln Asn Gln Ala His
    50                  55                  60                  
Gly Lys Gly Gly His Arg Gly Gly Gly Gly Gly Gly Gly Lys Ser Ser
65                  70                  75                  80  
Ser Ser Ser Ser Ala Ser Ala Ala Ala Ala Ala Ala Ala Ala Ser Ser
                85                  90                  95      
Ser Ala Ser Cys Ser Arg Arg Leu Gly Arg Ala Leu Asn Phe Leu Phe
            100                 105                 110         
Tyr Leu Ala Leu Val Ala Ala Ala Ala Phe Ser Gly Trp Cys Val His
        115                 120                 125             
His Val Leu Glu Glu Val Gln Gln Val Arg Arg Ser His Gln Asp Phe
    130                 135                 140                 
Ser Arg Gln Arg Glu Glu Leu Gly Gln Gly Leu Gln Gly Val Glu Gln
145                 150                 155                 160 
Lys Val Gln Ser Leu Gln Ala Thr Phe Gly Thr Phe Glu Ser Ile Leu
                165                 170                 175     
Arg Ser Ser Gln His Lys Gln Asp Leu Thr Glu Lys Ala Val Lys Gln
            180                 185                 190         
Gly Glu Ser Glu Val Ser Arg Ile Ser Glu Val Leu Gln Lys Leu Gln
        195                 200                 205             
Asn Glu Ile Leu Lys Asp Leu Ser Asp Gly Ile His Val Val Lys Asp
    210                 215                 220                 
Ala Arg Glu Arg Asp Phe Thr Ser Leu Glu Asn Thr Val Glu Glu Arg
225                 230                 235                 240 
Leu Thr Glu Leu Thr Lys Ser Ile Asn Asp Asn Ile Ala Ile Phe Thr
                245                 250                 255     
Glu Val Gln Lys Arg Ser Gln Lys Glu Ile Asn Asp Met Lys Ala Lys
            260                 265                 270         
Val Ala Ser Leu Glu Glu Ser Glu Gly Asn Lys Gln Asp Leu Lys Ala
        275                 280                 285             
Leu Lys Glu Ala Val Lys Glu Ile Gln Thr Ser Ala Lys Ser Arg Glu
    290                 295                 300                 
Trp Asp Met Glu Ala Leu Arg Ser Thr Leu Gln Thr Met Glu Ser Asp
305                 310                 315                 320 
Ile Tyr Thr Glu Val Arg Glu Leu Val Ser Leu Lys Gln Glu Gln Gln
                325                 330                 335     
Ala Phe Lys Glu Ala Ala Asp Thr Glu Arg Leu Ala Leu Gln Ala Leu
            340                 345                 350         
Thr Glu Lys Leu Leu Arg Ser Glu Glu Ser Val Ser Arg Leu Pro Glu
        355                 360                 365             
Glu Ile Arg Arg Leu Glu Glu Glu Leu Arg Gln Leu Lys Ser Asp Ser
    370                 375                 380                 
His Gly Pro Lys Glu Asp Gly Gly Phe Arg His Ser Glu Ala Phe Glu
385                 390                 395                 400 
Ala Leu Gln Gln Lys Ser Gln Gly Leu Asp Ser Arg Leu Gln His Val
                405                 410                 415     
Glu Asp Gly Val Leu Ser Met Gln Val Ala Ser Ala Arg Gln Thr Glu
            420                 425                 430         
Ser Leu Glu Ser Leu Leu Ser Lys Ser Gln Glu His Glu Gln Arg Leu
        435                 440                 445             
Ala Ala Leu Gln Gly Arg Leu Glu Gly Leu Gly Ser Ser Glu Ala Asp
    450                 455                 460                 
Gln Asp Gly Leu Ala Ser Thr Val Arg Ser Leu Gly Glu Thr Gln Leu
465                 470                 475                 480 
Val Leu Tyr Gly Asp Val Glu Glu Leu Lys Arg Ser Val Gly Glu Leu
                485                 490                 495     
Pro Ser Thr Val Glu Ser Leu Gln Lys Val Gln Glu Gln Val His Thr
            500                 505                 510         
Leu Leu Ser Gln Asp Gln Ala Gln Ala Ala Arg Leu Pro Pro Gln Asp
        515                 520                 525             
Phe Leu Asp Arg Leu Ser Ser Leu Asp Asn Leu Lys Ala Ser Val Ser
    530                 535                 540                 
Gln Val Glu Ala Asp Leu Lys Met Leu Arg Thr Ala Val Asp Ser Leu
545                 550                 555                 560 
Val Ala Tyr Ser Val Lys Ile Glu Thr Asn Glu Asn Asn Leu Glu Ser
                565                 570                 575     
Ala Lys Gly Leu Leu Asp Asp Leu Arg Asn Asp Leu Asp Arg Leu Phe
            580                 585                 590         
Val Lys Val Glu Lys Ile His Glu Lys Val
        595                 600         


<210> 2159
<211> 289
<212> PRT
<213> Homo sapiens

<400> 2159
Met Ala Gln Asn Leu Lys Asp Leu Ala Gly Arg Leu Pro Ala Gly Pro
 1               5                  10                  15      
Arg Gly Met Gly Thr Ala Leu Lys Leu Leu Leu Gly Ala Gly Ala Val
            20                  25                  30          
Ala Tyr Gly Val Arg Glu Ser Val Phe Thr Val Glu Gly Gly His Arg
        35                  40                  45              
Ala Ile Phe Phe Asn Arg Ile Gly Gly Val Gln Gln Asp Thr Ile Leu
    50                  55                  60                  
Ala Glu Gly Leu His Phe Arg Ile Pro Trp Phe Gln Tyr Pro Ile Ile
65                  70                  75                  80  
Tyr Asp Ile Arg Ala Arg Pro Arg Lys Ile Ser Ser Pro Thr Gly Ser
                85                  90                  95      
Lys Asp Leu Gln Met Val Asn Ile Ser Leu Arg Val Leu Ser Arg Pro
            100                 105                 110         
Asn Ala Gln Glu Leu Pro Ser Met Tyr Gln Arg Leu Gly Leu Asp Tyr
        115                 120                 125             
Glu Glu Arg Val Leu Pro Ser Ile Val Asn Glu Val Leu Lys Ser Val
    130                 135                 140                 
Val Ala Lys Phe Asn Ala Ser Gln Leu Ile Thr Gln Arg Ala Gln Val
145                 150                 155                 160 
Ser Leu Leu Ile Arg Arg Glu Leu Thr Glu Arg Ala Lys Asp Phe Ser
                165                 170                 175     
Leu Ile Leu Asp Asp Val Ala Ile Thr Glu Leu Ser Phe Ser Arg Glu
            180                 185                 190         
Tyr Thr Ala Ala Val Glu Ala Lys Gln Val Ala Gln Gln Glu Ala Gln
        195                 200                 205             
Arg Ala Gln Phe Leu Val Glu Lys Ala Lys Gln Glu Gln Arg Gln Lys
    210                 215                 220                 
Ile Val Gln Ala Glu Gly Glu Ala Glu Ala Ala Lys Met Leu Gly Glu
225                 230                 235                 240 
Ala Leu Ser Lys Asn Pro Gly Tyr Ile Lys Leu Arg Lys Ile Arg Ala
                245                 250                 255     
Ala Gln Asn Ile Ser Lys Thr Ile Ala Thr Ser Gln Asn Arg Ile Tyr
            260                 265                 270         
Leu Thr Ala Asp Asn Leu Val Leu Asn Leu Gln Asp Glu Ser Phe Thr
        275                 280                 285             
Arg
    


<210> 2160
<211> 706
<212> PRT
<213> Homo sapiens

<400> 2160
Met His Ile Phe Ile Glu Ser Gly Leu Arg Leu Leu His Leu Ser Leu
 1               5                  10                  15      
Lys Thr Ser Lys Ile Lys Ser Ser Gly Glu Cys Val Leu Glu Met Leu
            20                  25                  30          
Asp Pro Phe Val Ser Leu Leu Ile Asp Cys Leu Gly Ser Met Asp Val
        35                  40                  45              
Lys Val Ile Thr Gly Ala Leu Gln Cys Leu Ile Trp Val Leu Arg Phe
    50                  55                  60                  
Pro Leu Pro Ser Ile Glu Thr Lys Ala Glu Gln Leu Thr Lys His Leu
65                  70                  75                  80  
Phe Leu Leu Leu Lys Asp Tyr Ala Lys Leu Gly Ala Ala Arg Gly Gln
                85                  90                  95      
Asn Phe His Leu Val Val Asn Cys Phe Lys Cys Val Thr Ile Leu Val
            100                 105                 110         
Lys Lys Val Lys Ser Tyr Gln Ile Thr Glu Lys Gln Leu Gln Val Leu
        115                 120                 125             
Leu Ala Tyr Ala Glu Glu Asp Ile Tyr Asp Thr Ser Arg Gln Ala Thr
    130                 135                 140                 
Ala Phe Gly Leu Leu Lys Ala Ile Leu Ser Arg Lys Leu Leu Val Pro
145                 150                 155                 160 
Glu Ile Asp Glu Val Met Arg Lys Val Ser Lys Leu Ala Val Ser Ala
                165                 170                 175     
Gln Ser Glu Pro Ala Arg Val Gln Cys Arg Gln Val Phe Leu Lys Tyr
            180                 185                 190         
Ile Leu Asp Tyr Pro Leu Gly Asp Lys Leu Arg Pro Asn Leu Glu Phe
        195                 200                 205             
Met Leu Ala Gln Leu Asn Tyr Glu His Glu Thr Gly Arg Glu Ser Thr
    210                 215                 220                 
Leu Glu Met Ile Ala Tyr Leu Phe Asp Thr Phe Pro Gln Gly Leu Leu
225                 230                 235                 240 
His Glu Asn Cys Gly Met Phe Phe Ile Pro Leu Cys Leu Met Thr Ile
                245                 250                 255     
Asn Asp Asp Ser Ala Thr Cys Lys Lys Met Ala Ser Met Thr Ile Lys
            260                 265                 270         
Ser Leu Leu Gly Lys Ile Ser Leu Glu Lys Lys Asp Trp Leu Phe Asp
        275                 280                 285             
Met Val Thr Thr Trp Phe Gly Ala Lys Lys Arg Leu Asn Arg Gln Leu
    290                 295                 300                 
Ala Ala Leu Ile Cys Gly Leu Phe Val Glu Ser Glu Gly Val Asp Phe
305                 310                 315                 320 
Glu Lys Arg Leu Gly Thr Val Leu Pro Val Ile Glu Lys Glu Ile Asp
                325                 330                 335     
Pro Glu Asn Phe Lys Asp Ile Met Glu Glu Thr Glu Glu Lys Ala Ala
            340                 345                 350         
Asp Arg Leu Leu Phe Ser Phe Leu Thr Leu Ile Thr Lys Leu Ile Lys
        355                 360                 365             
Glu Cys Asn Ile Ile Gln Phe Thr Lys Pro Ala Glu Thr Leu Ser Lys
    370                 375                 380                 
Ile Trp Ser His Val His Ser His Leu Arg His Pro His Asn Trp Val
385                 390                 395                 400 
Trp Leu Thr Ala Ala Gln Ile Phe Gly Leu Leu Phe Ala Ser Cys Gln
                405                 410                 415     
Pro Glu Glu Leu Ile Gln Lys Trp Asn Thr Lys Lys Thr Lys Lys His
            420                 425                 430         
Leu Pro Glu Pro Val Ala Ile Lys Phe Leu Ala Ser Asp Leu Asp Gln
        435                 440                 445             
Lys Met Lys Ser Ile Ser Leu Ala Ser Cys His Gln Leu His Ser Lys
    450                 455                 460                 
Phe Leu Asp Gln Ser Leu Gly Glu Gln Val Val Lys Asn Leu Leu Phe
465                 470                 475                 480 
Ala Ala Lys Val Leu Tyr Leu Leu Glu Leu Tyr Cys Glu Asp Lys Gln
                485                 490                 495     
Ser Lys Ile Lys Glu Asp Leu Glu Glu Gln Glu Ala Leu Glu Asp Gly
            500                 505                 510         
Val Ala Cys Ala Asp Glu Lys Ala Glu Ser Asp Gly Glu Glu Lys Glu
        515                 520                 525             
Glu Val Lys Glu Glu Leu Gly Arg Pro Ala Thr Leu Leu Trp Leu Ile
    530                 535                 540                 
Gln Lys Leu Ser Arg Ile Ala Lys Leu Glu Ala Ala Tyr Ser Pro Arg
545                 550                 555                 560 
Asn Pro Leu Lys Arg Thr Cys Ile Phe Lys Phe Leu Gly Ala Val Ala
                565                 570                 575     
Met Asp Leu Gly Ile Asp Lys Val Lys Pro Tyr Leu Pro Met Ile Ile
            580                 585                 590         
Ala Pro Leu Phe Arg Glu Leu Asn Ser Thr Tyr Ser Glu Gln Asp Pro
        595                 600                 605             
Leu Leu Lys Asn Leu Ser Gln Glu Ile Ile Glu Leu Leu Lys Lys Leu
    610                 615                 620                 
Val Gly Leu Glu Ser Phe Ser Leu Ala Phe Ala Ser Val Gln Lys Gln
625                 630                 635                 640 
Ala Asn Glu Lys Arg Ala Leu Arg Lys Lys Arg Lys Ala Leu Glu Phe
                645                 650                 655     
Val Thr Asn Pro Asp Ile Ala Ala Lys Lys Lys Met Lys Lys His Lys
            660                 665                 670         
Asn Lys Ser Glu Ala Lys Lys Arg Lys Ile Glu Phe Leu Arg Pro Gly
        675                 680                 685             
Tyr Lys Ala Lys Arg Gln Lys Ser His Ser Leu Lys Asp Leu Ala Met
    690                 695                 700                 
Val Glu
705     


<210> 2161
<211> 122
<212> PRT
<213> Homo sapiens

<400> 2161
Met Thr Ser Pro Glu Ile Ala Ser Leu Ser Trp Gly Gln Met Lys Val
 1               5                  10                  15      
Lys Gly Ser Asn Thr Thr Tyr Lys Asp Cys Lys Val Trp Pro Gly Gly
            20                  25                  30          
Ser Arg Thr Trp Asp Trp Arg Glu Thr Gly Thr Glu His Ser Pro Gly
        35                  40                  45              
Val Gln Pro Ala Asp Val Lys Glu Val Val Glu Lys Gly Val Gln Thr
    50                  55                  60                  
Leu Val Ile Gly Arg Gly Met Ser Glu Ala Leu Lys Val Pro Ser Ser
65                  70                  75                  80  
Thr Val Glu Tyr Leu Lys Lys His Gly Ile Asp Val Arg Val Leu Gln
                85                  90                  95      
Thr Glu Gln Ala Val Lys Glu Tyr Asn Ala Leu Val Ala Gln Gly Val
            100                 105                 110         
Arg Val Gly Gly Val Phe His Ser Thr Cys
        115                 120         


<210> 2162
<211> 424
<212> PRT
<213> Homo sapiens

<400> 2162
Met Ala Pro Glu Glu Asp Ala Gly Gly Glu Ala Leu Gly Gly Ser Phe
 1               5                  10                  15      
Trp Glu Ala Gly Asn Tyr Arg Arg Thr Val Gln Arg Val Glu Asp Gly
            20                  25                  30          
His Arg Leu Cys Gly Asp Leu Val Ser Cys Phe Gln Glu Arg Ala Arg
        35                  40                  45              
Ile Glu Lys Ala Tyr Ala Gln Gln Leu Ala Asp Trp Ala Arg Lys Trp
    50                  55                  60                  
Arg Gly Thr Val Glu Lys Gly Pro Gln Tyr Gly Thr Leu Glu Lys Ala
65                  70                  75                  80  
Trp His Ala Phe Phe Thr Ala Ala Glu Arg Leu Ser Ala Leu His Leu
                85                  90                  95      
Glu Val Arg Glu Lys Leu Gln Gly Gln Asp Ser Glu Arg Val Arg Ala
            100                 105                 110         
Trp Gln Arg Gly Ala Phe His Arg Pro Val Leu Gly Gly Phe Arg Glu
        115                 120                 125             
Ser Arg Ala Ala Glu Asp Gly Phe Arg Lys Ala Gln Lys Pro Trp Leu
    130                 135                 140                 
Lys Arg Leu Lys Glu Val Glu Ala Ser Lys Lys Ser Tyr His Ala Ala
145                 150                 155                 160 
Arg Lys Asp Glu Lys Thr Ala Gln Thr Arg Glu Ser His Ala Lys Ala
                165                 170                 175     
Asp Ser Ala Val Ser Gln Glu Gln Leu Arg Lys Leu Gln Glu Arg Val
            180                 185                 190         
Glu Arg Cys Ala Lys Glu Ala Glu Lys Thr Lys Ala Gln Tyr Glu Gln
        195                 200                 205             
Thr Leu Ala Glu Leu His Arg Tyr Thr Pro Arg Tyr Met Glu Asp Met
    210                 215                 220                 
Glu Gln Ala Phe Glu Thr Cys Gln Ala Ala Glu Arg Gln Arg Leu Leu
225                 230                 235                 240 
Phe Phe Lys Asp Met Leu Leu Thr Leu His Gln His Leu Asp Leu Ser
                245                 250                 255     
Ser Ser Glu Lys Phe His Glu Leu His Arg Asp Leu His Gln Gly Ile
            260                 265                 270         
Glu Ala Ala Ser Asp Glu Glu Asp Leu Arg Trp Trp Arg Ser Thr His
        275                 280                 285             
Gly Pro Gly Met Ala Met Asn Trp Pro Gln Phe Glu Glu Trp Ser Leu
    290                 295                 300                 
Asp Thr Gln Arg Thr Ile Ser Arg Lys Glu Lys Gly Gly Arg Ser Pro
305                 310                 315                 320 
Asp Glu Val Thr Leu Thr Ser Ile Val Pro Thr Arg Asp Gly Thr Ala
                325                 330                 335     
Pro Pro Pro Gln Ser Pro Gly Ser Pro Gly Thr Gly Gln Asp Glu Glu
            340                 345                 350         
Trp Ser Asp Glu Glu Ser Pro Arg Lys Ala Ala Thr Gly Val Arg Val
        355                 360                 365             
Arg Ala Leu Tyr Asp Tyr Ala Gly Gln Glu Ala Asp Glu Leu Ser Phe
    370                 375                 380                 
Arg Ala Gly Glu Glu Leu Leu Lys Met Ser Glu Glu Asp Glu Gln Gly
385                 390                 395                 400 
Trp Cys Gln Gly Gln Leu Gln Ser Gly Arg Ile Gly Leu Tyr Pro Ala
                405                 410                 415     
Asn Tyr Val Glu Cys Val Gly Ala
            420                 


<210> 2163
<211> 720
<212> PRT
<213> Homo sapiens

<400> 2163
Met Val Gly Ala Lys Asp Gln Ala Val Phe Lys Cys Glu Val Ser Asp
 1               5                  10                  15      
Glu Asn Val Arg Gly Val Trp Leu Lys Asn Gly Lys Glu Leu Val Pro
            20                  25                  30          
Asp Ser Arg Ile Lys Val Ser His Ile Gly Arg Val His Lys Leu Thr
        35                  40                  45              
Ile Asp Asp Val Thr Pro Ala Asp Glu Ala Asp Tyr Ser Phe Val Pro
    50                  55                  60                  
Glu Gly Phe Ala Cys Asn Leu Ser Ala Lys Leu His Phe Met Glu Val
65                  70                  75                  80  
Lys Ile Asp Phe Val Pro Arg Gln Glu Pro Pro Lys Ile His Leu Asp
                85                  90                  95      
Cys Pro Gly Arg Ile Pro Asp Thr Ile Val Val Val Ala Gly Asn Lys
            100                 105                 110         
Leu Arg Leu Asp Val Pro Ile Ser Gly Asp Pro Ala Pro Thr Val Ile
        115                 120                 125             
Trp Gln Lys Ala Ile Thr Gln Gly Asn Lys Ala Pro Ala Arg Pro Ala
    130                 135                 140                 
Pro Asp Ala Pro Glu Asp Thr Gly Asp Ser Asp Glu Trp Val Phe Asp
145                 150                 155                 160 
Lys Lys Leu Leu Cys Glu Thr Glu Gly Arg Val Arg Val Glu Thr Thr
                165                 170                 175     
Lys Asp Arg Ser Ile Phe Thr Val Glu Gly Ala Glu Lys Glu Asp Glu
            180                 185                 190         
Gly Val Tyr Thr Val Thr Val Lys Asn Pro Val Gly Glu Asp Gln Val
        195                 200                 205             
Asn Leu Thr Val Lys Val Ile Asp Val Pro Asp Ala Pro Ala Ala Pro
    210                 215                 220                 
Lys Ile Ser Asn Val Gly Glu Asp Ser Cys Thr Val Gln Trp Glu Pro
225                 230                 235                 240 
Pro Ala Tyr Asp Gly Gly Gln Pro Ile Leu Gly Tyr Ile Leu Glu Arg
                245                 250                 255     
Lys Lys Lys Lys Ser Tyr Arg Trp Met Arg Leu Asn Phe Asp Leu Ile
            260                 265                 270         
Gln Glu Leu Ser His Glu Ala Arg Arg Met Ile Glu Gly Val Val Tyr
        275                 280                 285             
Glu Met Arg Val Tyr Ala Val Asn Ala Ile Gly Met Ser Arg Pro Ser
    290                 295                 300                 
Pro Ala Ser Gln Pro Phe Met Pro Ile Gly Pro Pro Ser Glu Pro Thr
305                 310                 315                 320 
His Leu Ala Val Glu Asp Val Ser Asp Thr Thr Val Ser Leu Lys Trp
                325                 330                 335     
Arg Pro Pro Glu Arg Val Gly Ala Gly Gly Leu Asp Gly Tyr Ser Val
            340                 345                 350         
Glu Tyr Cys Pro Glu Gly Cys Ser Glu Trp Val Ala Ala Leu Gln Gly
        355                 360                 365             
Leu Thr Glu His Thr Ser Ile Leu Val Lys Asp Leu Pro Thr Gly Ala
    370                 375                 380                 
Arg Leu Leu Phe Arg Val Arg Ala His Asn Met Ala Gly Pro Gly Ala
385                 390                 395                 400 
Pro Val Thr Thr Thr Glu Pro Val Thr Val Gln Glu Ile Leu Gln Arg
                405                 410                 415     
Pro Arg Leu Gln Leu Pro Arg His Leu Arg Gln Thr Ile Gln Lys Lys
            420                 425                 430         
Val Gly Glu Pro Val Asn Leu Leu Ile Pro Phe Gln Gly Lys Pro Arg
        435                 440                 445             
Pro Gln Val Thr Trp Thr Lys Glu Gly Gln Pro Leu Ala Gly Glu Glu
    450                 455                 460                 
Val Ser Ile Arg Asn Ser Pro Thr Asp Thr Ile Leu Phe Ile Arg Ala
465                 470                 475                 480 
Ala Arg Arg Val His Ser Gly Thr Tyr Gln Val Thr Val Arg Ile Glu
                485                 490                 495     
Asn Met Glu Asp Lys Ala Thr Leu Val Leu Gln Val Val Asp Lys Pro
            500                 505                 510         
Ser Pro Pro Gln Asp Leu Arg Val Thr Asp Ala Trp Gly Leu Asn Val
        515                 520                 525             
Ala Leu Glu Trp Lys Pro Pro Gln Asp Val Gly Asn Thr Glu Leu Trp
    530                 535                 540                 
Gly Tyr Thr Val Gln Lys Ala Asp Lys Lys Thr Met Glu Trp Phe Thr
545                 550                 555                 560 
Val Leu Glu His Tyr Arg Arg Thr His Cys Val Val Pro Glu Leu Ile
                565                 570                 575     
Ile Gly Asn Gly Tyr Tyr Phe Arg Val Phe Ser Gln Asn Met Val Gly
            580                 585                 590         
Phe Ser Asp Arg Ala Ala Thr Thr Lys Glu Pro Val Phe Ile Pro Arg
        595                 600                 605             
Pro Gly Ile Thr Tyr Glu Pro Pro Asn Tyr Lys Ala Leu Asp Phe Ser
    610                 615                 620                 
Glu Ala Pro Ser Phe Thr Gln Pro Leu Val Asn Arg Ser Val Ile Ala
625                 630                 635                 640 
Gly Tyr Thr Ala Met Leu Cys Cys Ala Val Arg Gly Ser Pro Lys Pro
                645                 650                 655     
Lys Ile Ser Trp Phe Lys Asn Gly Leu Asp Leu Gly Glu Asp Ala Arg
            660                 665                 670         
Phe Arg Met Phe Ser Lys Gln Gly Val Leu Thr Leu Glu Ile Arg Lys
        675                 680                 685             
Pro Cys Pro Phe Asp Gly Gly Ile Tyr Val Cys Arg Ala Thr Asn Leu
    690                 695                 700                 
Gln Gly Glu Ala Arg Cys Glu Cys Arg Leu Glu Val Arg Val Pro Gln
705                 710                 715                 720 


<210> 2164
<211> 1042
<212> PRT
<213> Homo sapiens

<400> 2164
Met Glu Asn Ala His Thr Lys Thr Val Glu Glu Val Leu Gly His Phe
 1               5                  10                  15      
Gly Val Asn Glu Ser Thr Gly Leu Ser Leu Glu Gln Val Lys Lys Leu
            20                  25                  30          
Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr
        35                  40                  45              
Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile
    50                  55                  60                  
Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu
65                  70                  75                  80  
Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu
                85                  90                  95      
Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala
            100                 105                 110         
Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys
        115                 120                 125             
Val Tyr Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp
    130                 135                 140                 
Ile Val Pro Gly Asp Ile Val Glu Ile Ala Val Gly Asp Lys Val Pro
145                 150                 155                 160 
Ala Asp Ile Arg Leu Thr Ser Ile Lys Ser Thr Thr Leu Arg Val Asp
                165                 170                 175     
Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Asp
            180                 185                 190         
Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu
        195                 200                 205             
Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Met Gly Val Val Val
    210                 215                 220                 
Ala Thr Gly Val Asn Thr Glu Ile Gly Lys Ile Arg Asp Glu Met Val
225                 230                 235                 240 
Ala Thr Glu Gln Glu Arg Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe
                245                 250                 255     
Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Ile Ala Val Trp
            260                 265                 270         
Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp
        275                 280                 285             
Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val
    290                 295                 300                 
Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala
305                 310                 315                 320 
Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu
                325                 330                 335     
Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys
            340                 345                 350         
Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Ile
        355                 360                 365             
Leu Asp Arg Val Glu Gly Asp Thr Cys Ser Leu Asn Glu Phe Thr Ile
    370                 375                 380                 
Thr Gly Ser Thr Tyr Ala Pro Ile Gly Glu Val His Lys Asp Asp Lys
385                 390                 395                 400 
Pro Val Asn Cys His Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile
                405                 410                 415     
Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly
            420                 425                 430         
Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu
        435                 440                 445             
Val Glu Lys Met Asn Val Phe Asp Thr Glu Leu Lys Gly Leu Ser Lys
    450                 455                 460                 
Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Lys Gln Leu Met Lys
465                 470                 475                 480 
Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val
                485                 490                 495     
Tyr Cys Thr Pro Asn Lys Pro Ser Arg Thr Ser Met Ser Lys Met Phe
            500                 505                 510         
Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Thr His Ile Arg
        515                 520                 525             
Val Gly Ser Thr Lys Val Pro Met Thr Ser Gly Val Lys Gln Lys Ile
    530                 535                 540                 
Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys
545                 550                 555                 560 
Leu Ala Leu Ala Thr His Asp Asn Pro Leu Arg Arg Glu Glu Met His
                565                 570                 575     
Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu Thr Asn Leu Thr Phe
            580                 585                 590         
Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Ile Glu Val Ala Ser
        595                 600                 605             
Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg Val Ile Met Ile Thr
    610                 615                 620                 
Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Ile Gly Ile
625                 630                 635                 640 
Phe Gly Gln Asp Glu Asp Val Thr Ser Lys Ala Phe Thr Gly Arg Glu
                645                 650                 655     
Phe Asp Glu Leu Asn Pro Ser Ala Gln Arg Asp Ala Cys Leu Asn Ala
            660                 665                 670         
Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu
        675                 680                 685             
Phe Leu Gln Ser Phe Asp Glu Ile Thr Ala Met Thr Gly Asp Gly Val
    690                 695                 700                 
Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met Gly
705                 710                 715                 720 
Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala Asp
                725                 730                 735     
Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile
            740                 745                 750         
Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val
        755                 760                 765             
Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Phe Pro Glu
    770                 775                 780                 
Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly
785                 790                 795                 800 
Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met
                805                 810                 815     
Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile Ser Gly Trp Leu
            820                 825                 830         
Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala Ala Thr Val
        835                 840                 845             
Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp Gly Gly Pro Arg Val
    850                 855                 860                 
Ser Phe Tyr Gln Leu Ser His Phe Leu Gln Cys Lys Glu Asp Asn Pro
865                 870                 875                 880 
Asp Phe Glu Gly Val Asp Cys Ala Ile Phe Glu Ser Pro Tyr Pro Met
                885                 890                 895     
Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu
            900                 905                 910         
Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Glu
        915                 920                 925             
Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser Leu His Phe
    930                 935                 940                 
Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe Gln Ile Thr Pro
945                 950                 955                 960 
Leu Asn Val Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro Val
                965                 970                 975     
Ile Leu Met Asp Glu Thr Leu Lys Phe Val Ala Arg Asn Tyr Leu Glu
            980                 985                 990         
Pro Gly Lys Glu Cys Val Gln Pro Ala Thr Lys Ser Cys Ser Phe Ser
        995                 1000                1005            
Ala Cys Thr Asp Gly Ile Ser Trp Pro Phe Val Leu Leu Ile Met Pro
    1010                1015                1020                
Leu Val Ile Trp Val Tyr Ser Thr Asp Thr Asn Phe Ser Asp Met Phe
1025                1030                1035                1040
Trp Ser
        


<210> 2165
<211> 613
<212> PRT
<213> Homo sapiens

<400> 2165
Met Ala Ala Gln Ala Ala Ala Ala Ala Gln Ala Ala Ala Ala Gln Ala
 1               5                  10                  15      
Ala Gln Ala Glu Ala Ala Asp Ser Trp Tyr Leu Ala Leu Leu Gly Phe
            20                  25                  30          
Ala Glu His Phe Arg Thr Ser Ser Pro Pro Lys Ile Arg Leu Cys Val
        35                  40                  45              
His Cys Leu Gln Ala Val Phe Pro Phe Lys Pro Pro Gln Arg Ile Glu
    50                  55                  60                  
Ala Arg Thr His Leu Gln Leu Gly Ser Val Leu Tyr His His Thr Lys
65                  70                  75                  80  
Asn Ser Glu Gln Ala Arg Ser His Leu Glu Lys Ala Trp Leu Ile Ser
                85                  90                  95      
Gln Gln Ile Pro Gln Phe Glu Asp Val Lys Phe Glu Ala Ala Ser Leu
            100                 105                 110         
Leu Ser Glu Leu Tyr Cys Gln Glu Asn Ser Val Asp Ala Ala Lys Pro
        115                 120                 125             
Leu Leu Arg Lys Ala Ile Gln Ile Ser Gln Gln Thr Pro Tyr Trp His
    130                 135                 140                 
Cys Arg Leu Leu Phe Gln Leu Ala Gln Leu His Thr Leu Glu Lys Asp
145                 150                 155                 160 
Leu Val Ser Ala Cys Asp Leu Leu Gly Val Gly Ala Glu Tyr Ala Arg
                165                 170                 175     
Val Val Gly Ser Glu Tyr Thr Arg Ala Leu Phe Leu Leu Ser Lys Gly
            180                 185                 190         
Met Leu Leu Leu Met Glu Arg Lys Leu Gln Glu Val His Pro Leu Leu
        195                 200                 205             
Thr Leu Cys Gly Gln Ile Val Glu Asn Trp Gln Gly Asn Pro Ile Gln
    210                 215                 220                 
Lys Glu Ser Leu Arg Val Phe Phe Leu Val Leu Gln Val Thr His Tyr
225                 230                 235                 240 
Leu Asp Ala Gly Gln Val Lys Ser Val Lys Pro Cys Leu Lys Gln Leu
                245                 250                 255     
Gln Gln Cys Ile Gln Thr Ile Ser Thr Leu His Asp Asp Glu Ile Leu
            260                 265                 270         
Pro Ser Asn Pro Ala Asp Leu Phe His Trp Leu Pro Lys Glu His Met
        275                 280                 285             
Cys Val Leu Val Tyr Leu Val Thr Val Met His Ser Met Gln Ala Gly
    290                 295                 300                 
Tyr Leu Glu Lys Ala Gln Lys Tyr Thr Asp Lys Ala Leu Met Gln Leu
305                 310                 315                 320 
Glu Lys Leu Lys Met Leu Asp Cys Ser Pro Ile Leu Ser Ser Phe Gln
                325                 330                 335     
Val Ile Leu Leu Glu His Ile Ile Met Cys Arg Leu Val Thr Gly His
            340                 345                 350         
Lys Ala Thr Ala Leu Gln Glu Ile Ser Gln Val Cys Gln Leu Cys Gln
        355                 360                 365             
Gln Ser Pro Arg Leu Phe Ser Asn His Ala Ala Gln Leu His Thr Leu
    370                 375                 380                 
Leu Gly Leu Tyr Cys Val Ser Val Asn Cys Met Asp Asn Ala Glu Ala
385                 390                 395                 400 
Gln Phe Thr Thr Ala Leu Arg Leu Thr Asn His Gln Glu Leu Trp Ala
                405                 410                 415     
Phe Ile Val Thr Asn Leu Ala Ser Val Tyr Ile Arg Glu Gly Asn Arg
            420                 425                 430         
His Gln Glu Val Leu Tyr Ser Leu Leu Glu Arg Ile Asn Pro Asp His
        435                 440                 445             
Ser Phe Pro Val Ser Ser His Cys Leu Arg Ala Ala Ala Phe Tyr Val
    450                 455                 460                 
Arg Gly Leu Phe Ser Phe Phe Gln Gly Arg Tyr Asn Glu Ala Lys Arg
465                 470                 475                 480 
Phe Leu Arg Glu Thr Leu Lys Met Ser Asn Ala Glu Asp Leu Asn Arg
                485                 490                 495     
Leu Thr Ala Cys Ser Leu Val Leu Leu Gly His Ile Phe Tyr Val Leu
            500                 505                 510         
Gly Asn His Arg Glu Ser Asn Asn Met Val Val Pro Ala Met Gln Leu
        515                 520                 525             
Ala Ser Lys Ile Pro Asp Met Ser Val Gln Leu Trp Ser Ser Ala Leu
    530                 535                 540                 
Leu Arg Asp Leu Asn Lys Ala Cys Gly Asn Ala Met Asp Ala His Glu
545                 550                 555                 560 
Ala Ala Gln Met His Gln Asn Phe Ser Gln Gln Leu Leu Gln Asp His
                565                 570                 575     
Ile Glu Ala Cys Ser Leu Pro Glu His Asn Leu Ile Thr Trp Thr Asp
            580                 585                 590         
Gly Pro Pro Pro Val Gln Phe Gln Ala Gln Asn Gly Pro Asn Thr Ser
        595                 600                 605             
Leu Ala Ser Leu Leu
    610             


<210> 2166
<211> 595
<212> PRT
<213> Homo sapiens

<400> 2166
Met Pro Ala Cys Cys Ser Cys Ser Asp Val Phe Gln Tyr Glu Thr Asn
 1               5                  10                  15      
Lys Val Thr Arg Ile Gln Ser Met Asn Tyr Gly Thr Ile Lys Trp Phe
            20                  25                  30          
Phe His Val Ile Ile Phe Ser Tyr Val Cys Phe Ala Leu Val Ser Asp
        35                  40                  45              
Lys Leu Tyr Gln Arg Lys Glu Pro Val Ile Ser Ser Val His Thr Lys
    50                  55                  60                  
Val Lys Gly Ile Ala Glu Val Lys Glu Glu Ile Val Glu Asn Gly Val
65                  70                  75                  80  
Lys Lys Leu Val His Ser Val Phe Asp Thr Ala Asp Tyr Thr Phe Pro
                85                  90                  95      
Leu Gln Gly Asn Ser Phe Phe Val Met Thr Asn Phe Leu Lys Thr Glu
            100                 105                 110         
Gly Gln Glu Gln Arg Leu Cys Pro Glu Tyr Pro Thr Arg Arg Thr Leu
        115                 120                 125             
Cys Ser Ser Asp Arg Gly Cys Lys Lys Gly Trp Met Asp Pro Gln Ser
    130                 135                 140                 
Lys Gly Ile Gln Thr Gly Arg Cys Val Val Tyr Glu Gly Asn Gln Lys
145                 150                 155                 160 
Thr Cys Glu Val Ser Ala Trp Cys Pro Ile Glu Ala Val Glu Glu Ala
                165                 170                 175     
Pro Arg Pro Ala Leu Leu Asn Ser Ala Glu Asn Phe Thr Val Leu Ile
            180                 185                 190         
Lys Asn Asn Ile Asp Phe Pro Gly His Asn Tyr Thr Thr Arg Asn Ile
        195                 200                 205             
Leu Pro Gly Leu Asn Ile Thr Cys Thr Phe His Lys Thr Gln Asn Pro
    210                 215                 220                 
Gln Cys Pro Ile Phe Arg Leu Gly Asp Ile Phe Arg Glu Thr Gly Asp
225                 230                 235                 240 
Asn Phe Ser Asp Val Ala Ile Gln Gly Gly Ile Met Gly Ile Glu Ile
                245                 250                 255     
Tyr Trp Asp Cys Asn Leu Asp Arg Trp Phe His His Cys Arg Pro Lys
            260                 265                 270         
Tyr Ser Phe Arg Arg Leu Asp Asp Lys Thr Thr Asn Val Ser Leu Tyr
        275                 280                 285             
Pro Gly Tyr Asn Phe Arg Tyr Ala Lys Tyr Tyr Lys Glu Asn Asn Val
    290                 295                 300                 
Glu Lys Arg Thr Leu Ile Lys Val Phe Gly Ile Arg Phe Asp Ile Leu
305                 310                 315                 320 
Val Phe Gly Thr Gly Gly Lys Phe Asp Ile Ile Gln Leu Val Val Tyr
                325                 330                 335     
Ile Gly Ser Thr Leu Ser Tyr Phe Gly Leu Ala Ala Val Phe Ile Asp
            340                 345                 350         
Phe Leu Ile Asp Thr Tyr Ser Ser Asn Cys Cys Arg Ser His Ile Tyr
        355                 360                 365             
Pro Trp Cys Lys Cys Cys Gln Pro Cys Val Val Asn Glu Tyr Tyr Tyr
    370                 375                 380                 
Arg Lys Lys Cys Glu Ser Ile Val Glu Pro Lys Pro Thr Leu Lys Tyr
385                 390                 395                 400 
Val Ser Phe Val Asp Glu Ser His Ile Arg Met Val Asn Gln Gln Leu
                405                 410                 415     
Leu Gly Arg Ser Leu Gln Asp Val Lys Gly Gln Glu Val Pro Arg Pro
            420                 425                 430         
Ala Met Asp Phe Thr Asp Leu Ser Arg Leu Pro Leu Ala Leu His Asp
        435                 440                 445             
Thr Pro Pro Ile Pro Gly Gln Pro Glu Glu Ile Gln Leu Leu Arg Lys
    450                 455                 460                 
Glu Ala Thr Pro Arg Ser Arg Asp Ser Pro Val Trp Cys Gln Cys Gly
465                 470                 475                 480 
Ser Cys Leu Pro Ser Gln Leu Pro Glu Ser His Arg Cys Leu Glu Glu
                485                 490                 495     
Leu Cys Cys Arg Lys Lys Pro Gly Ala Cys Ile Thr Thr Ser Glu Leu
            500                 505                 510         
Phe Arg Lys Leu Val Leu Ser Arg His Val Leu Gln Phe Leu Leu Leu
        515                 520                 525             
Tyr Gln Glu Pro Leu Leu Ala Leu Asp Val Asp Ser Thr Asn Ser Arg
    530                 535                 540                 
Leu Arg His Cys Ala Tyr Arg Cys Tyr Ala Thr Trp Arg Phe Gly Ser
545                 550                 555                 560 
Gln Asp Met Ala Asp Phe Ala Asn Leu Pro Ser Cys Cys Arg Trp Arg
                565                 570                 575     
Ile Arg Lys Glu Phe Pro Lys Ser Glu Gly Gln Tyr Ser Gly Phe Lys
            580                 585                 590         
Ser Pro Tyr
        595 


<210> 2167
<211> 268
<212> PRT
<213> Homo sapiens

<400> 2167
Met Glu Ala Leu Pro Leu Leu Ala Ala Thr Thr Pro Asp His Gly Arg
 1               5                  10                  15      
His Arg Arg Leu Leu Leu Leu Pro Leu Leu Leu Phe Leu Leu Pro Ala
            20                  25                  30          
Gly Ala Val Gln Gly Trp Glu Thr Glu Glu Arg Pro Arg Thr Arg Glu
        35                  40                  45              
Glu Glu Cys His Phe Tyr Ala Gly Gly Gln Val Tyr Pro Gly Glu Ala
    50                  55                  60                  
Ser Arg Val Ser Val Ala Asp His Ser Leu His Leu Ser Lys Ala Lys
65                  70                  75                  80  
Ile Ser Lys Pro Ala Pro Tyr Trp Glu Gly Thr Ala Val Ile Asp Gly
                85                  90                  95      
Glu Phe Lys Glu Leu Lys Leu Thr Asp Tyr Arg Gly Lys Tyr Leu Val
            100                 105                 110         
Phe Phe Phe Tyr Pro Leu Asp Phe Thr Phe Val Cys Pro Thr Glu Ile
        115                 120                 125             
Ile Ala Phe Gly Asp Arg Leu Glu Glu Phe Arg Ser Ile Asn Thr Glu
    130                 135                 140                 
Val Val Ala Cys Ser Val Asp Ser Gln Phe Thr His Leu Ala Trp Ile
145                 150                 155                 160 
Asn Thr Pro Arg Arg Gln Gly Gly Leu Gly Pro Ile Arg Ile Pro Leu
                165                 170                 175     
Leu Ser Asp Leu Thr His Gln Ile Ser Lys Asp Tyr Gly Val Tyr Leu
            180                 185                 190         
Glu Asp Ser Gly His Thr Leu Arg Gly Leu Phe Ile Ile Asp Asp Lys
        195                 200                 205             
Gly Ile Leu Arg Gln Ile Thr Leu Asn Asp Leu Pro Val Gly Arg Ser
    210                 215                 220                 
Val Asp Glu Thr Leu Arg Leu Val Gln Ala Phe Gln Tyr Thr Asp Lys
225                 230                 235                 240 
His Gly Glu Val Cys Pro Ala Gly Trp Lys Pro Gly Ser Glu Thr Asp
                245                 250                 255     
Asn Pro Arg Ser Ser Trp Lys Ala Glu Val Phe Arg
            260                 265             


<210> 2168
<211> 113
<212> PRT
<213> Homo sapiens

<400> 2168
Met Ala Ser Ala Thr Arg Leu Ile Gln Arg Leu Arg Asn Trp Ala Ser
 1               5                  10                  15      
Gly His Asp Leu Gln Gly Lys Leu Gln Leu Arg Tyr Gln Glu Ile Ser
            20                  25                  30          
Lys Arg Thr Gln Pro Pro Pro Lys Leu Pro Val Gly Pro Ser His Lys
        35                  40                  45              
Leu Ser Asn Asn Tyr Tyr Cys Thr Arg Asp Gly Arg Arg Glu Ser Val
    50                  55                  60                  
Pro Pro Ser Ile Ile Met Ser Ser Gln Lys Ala Leu Val Ser Gly Lys
65                  70                  75                  80  
Pro Ala Glu Ser Ser Ala Val Ala Ala Thr Glu Lys Lys Ala Val Thr
                85                  90                  95      
Pro Ala Pro Pro Ile Lys Arg Trp Glu Leu Ser Ser Asp Gln Pro Tyr
            100                 105                 110         
Leu
    


<210> 2169
<211> 309
<212> PRT
<213> Homo sapiens

<400> 2169
Met Ala Asp Gly Gln His Glu Gly Cys Leu Pro Arg Leu Thr Gly Leu
 1               5                  10                  15      
Gly Ile Asp Ile Thr His Ala Glu Glu Ser Leu Asp His Ser His Val
            20                  25                  30          
Leu Leu Phe Leu Pro His Arg Gly Glu Cys Ser Gln His Glu Gly Arg
        35                  40                  45              
Val Ala Gly Ser Val Leu Ala Val Asp Leu Ala Gly Pro Arg Ile Gln
    50                  55                  60                  
Glu Gln Ala Cys Asp Gly Gln Val Pro Val Gly His Thr Val Val Gln
65                  70                  75                  80  
Gly Arg Val Pro Val Ala Ile Arg Gln Val His His Val Arg Gln Gln
                85                  90                  95      
Phe Gly Ser Gln Ala Pro His Pro Phe Gln His Pro Gly His Gly Leu
            100                 105                 110         
Arg Leu Arg Ala Pro Leu Ala Gly His Ser Lys Pro Leu Leu Gly His
        115                 120                 125             
Glu Ala His Cys Ala Ala Val Ala Gly Tyr Ser Ala Gly Pro Ala Gln
    130                 135                 140                 
Leu Pro Leu Gln Arg Tyr Ala Arg Leu Pro Gln Thr Arg Ala Gln Leu
145                 150                 155                 160 
Ala Pro Pro Leu Cys His Leu Leu Arg Leu Cys Leu Arg Leu Gly Leu
                165                 170                 175     
Arg Val Pro Asp Val Pro Ala Ala Gly Arg Ala Arg Gly Ala Arg Val
            180                 185                 190         
Gly Ser Pro Ala Ala Val Ile Pro Gly Ala Arg Gly Ala Thr Arg Gly
        195                 200                 205             
Leu Gly Ala Thr Val Leu Ala Val Ala Ile Ala Val Ala Gly Val Leu
    210                 215                 220                 
Ala Gly Gly Ala Leu Val Leu Ser Val Glu Asp Pro Asn Lys Leu Gln
225                 230                 235                 240 
Ala Leu Gly Ser Gly Ala Gly Leu Gly Thr Arg Cys Ala Val Ser Leu
                245                 250                 255     
Leu His Asp Gly Phe Glu Asp Ala Arg Gly Arg His Gly Pro Val Ser
            260                 265                 270         
Val His Gly Ser Gly Arg Ala Leu Leu Ser Gln Gly Gly Arg Leu Cys
        275                 280                 285             
Arg Gly Leu Gly Leu Arg Gly Leu Phe Gly Thr Ala Pro Arg Gly Leu
    290                 295                 300                 
Gly Gly Gly Leu Ala
305                 


<210> 2170
<211> 196
<212> PRT
<213> Homo sapiens

<400> 2170
Met Pro Val Tyr Cys Gly Asn Glu Val Thr Pro Thr Glu Ala Ala Gln
 1               5                  10                  15      
Ala Pro Glu Val Thr Tyr Glu Ala Glu Glu Gly Ser Leu Trp Thr Leu
            20                  25                  30          
Leu Leu Thr Ser Leu Asp Gly His Leu Leu Glu Pro Asp Ala Glu Tyr
        35                  40                  45              
Leu His Trp Leu Leu Thr Asn Ile Pro Gly Asn Arg Val Ala Glu Gly
    50                  55                  60                  
Gln Val Thr Cys Pro Tyr Leu Pro Pro Phe Pro Ala Arg Gly Ser Gly
65                  70                  75                  80  
Ile His Arg Leu Ala Phe Leu Leu Phe Lys Gln Asp Gln Pro Ile Asp
                85                  90                  95      
Phe Ser Glu Asp Ala Arg Pro Ser Pro Cys Tyr Gln Leu Ala Gln Arg
            100                 105                 110         
Thr Phe Arg Thr Phe Asp Phe Tyr Lys Lys His Gln Glu Thr Met Thr
        115                 120                 125             
Pro Ala Gly Leu Ser Phe Phe Gln Cys Arg Trp Asp Asp Ser Val Thr
    130                 135                 140                 
Tyr Ile Phe His Gln Leu Leu Asp Met Arg Glu Pro Val Phe Glu Phe
145                 150                 155                 160 
Val Arg Pro Pro Pro Tyr His Pro Lys Gln Lys Arg Phe Pro His Arg
                165                 170                 175     
Gln Pro Leu Arg Tyr Leu Asp Arg Tyr Arg Asp Ser His Glu Pro Thr
            180                 185                 190         
Tyr Gly Ile Tyr
        195     


<210> 2171
<211> 346
<212> PRT
<213> Homo sapiens

<400> 2171
Met Lys Asp Leu Asp Gly Met Asp Ala Asp Ile Leu Gly Leu Lys Lys
 1               5                  10                  15      
Ser Asn Ser Ala Pro Ser Lys Lys Ala Ala Lys Asp Pro Gly Lys Gly
            20                  25                  30          
Glu Leu Pro Asn His Pro Lys Pro Ala Gly Gly Ala Ile Pro Thr Lys
        35                  40                  45              
Lys Ser Leu Pro Ser Pro Ser Ser Ser Gly His Gln Asn Arg Arg Phe
    50                  55                  60                  
Ser Ser Glu Asp Leu Glu Asp Pro Leu Arg Gly Leu Leu Ser Tyr Asp
65                  70                  75                  80  
Glu Gly Gly Ile Thr Lys Gln Pro Pro Val Thr Gln Ser Lys Thr Ala
                85                  90                  95      
Ser Asp Lys Ser Pro Ser Thr Val Arg Asp Gln Gly Pro Ser Ile Pro
            100                 105                 110         
Leu Thr Pro Gly Asp Thr Pro Ile Arg Lys Lys Glu Glu Leu Leu Phe
        115                 120                 125             
Asp Asp Gly Asp Asp Ile Met Ala Thr Leu Gly Phe Gly Asp Ser Pro
    130                 135                 140                 
Lys Ala Glu Lys Arg Gln Ile Gly Asp Gln Glu Gly Pro Arg Pro Ala
145                 150                 155                 160 
Arg Ser Thr Leu Asp Glu Leu Leu Gly Arg Gly Met Ala Thr Lys Leu
                165                 170                 175     
Leu Ala Arg Pro Gly Thr Gly Glu His Arg Glu Phe Lys Leu Asp Lys
            180                 185                 190         
Lys Tyr Gln Arg Pro Gln Ala Val Lys Ile Cys Gly Val Thr Arg Thr
        195                 200                 205             
Ser Pro Leu Glu Pro Ile Ser Pro Leu Trp Ser Pro Leu Arg Ala Gly
    210                 215                 220                 
Ser Pro Ala Gly Ser Leu Ser Val Gly Ser Ser Gln Thr Val Ala Gln
225                 230                 235                 240 
Thr Pro Arg Glu Asn Gln Ala Pro Asn Arg Ala Leu Gln Trp Leu Pro
                245                 250                 255     
Ala Pro Ser Ser Pro Gly Arg Glu Glu Leu Thr Gly Trp Ala Ser Arg
            260                 265                 270         
Thr Arg Thr Trp Thr Cys Ser Leu Pro His Pro Pro Glu Arg Pro Ile
        275                 280                 285             
Gly Lys Val Gln Cys Leu Ser Arg Pro Gln Cys Leu Leu Leu Arg Ala
    290                 295                 300                 
Ser Thr Pro Arg Gln Leu Gly Cys Pro Pro Pro Gly Gln Ser His Gln
305                 310                 315                 320 
Leu Lys Val Gln Gly Pro Leu Pro Lys Pro Ala Arg Leu Pro Ser Cys
                325                 330                 335     
Glu Pro Pro Arg Arg Arg Lys Arg Thr Gly
            340                 345     


<210> 2172
<211> 600
<212> PRT
<213> Homo sapiens

<400> 2172
Met Arg Ser Cys Leu Trp Arg Cys Arg His Leu Ser Gln Gly Val Gln
 1               5                  10                  15      
Trp Ser Leu Leu Leu Ala Val Leu Val Phe Phe Leu Phe Ala Leu Pro
            20                  25                  30          
Ser Phe Ile Lys Glu Pro Gln Thr Lys Pro Ser Arg His Gln Arg Thr
        35                  40                  45              
Glu Asn Ile Lys Glu Arg Ser Leu Gln Ser Leu Ala Lys Pro Lys Ser
    50                  55                  60                  
Gln Ala Pro Thr Arg Ala Arg Arg Thr Thr Ile Tyr Ala Glu Pro Val
65                  70                  75                  80  
Pro Glu Asn Asn Ala Leu Asn Thr Gln Thr Gln Pro Lys Ala His Thr
                85                  90                  95      
Thr Gly Asp Arg Gly Lys Glu Ala Asn Gln Ala Pro Pro Glu Glu Gln
            100                 105                 110         
Asp Lys Val Pro His Thr Ala Gln Arg Ala Ala Trp Lys Ser Pro Glu
        115                 120                 125             
Lys Glu Lys Thr Met Val Asn Thr Leu Ser Pro Arg Gly Gln Asp Ala
    130                 135                 140                 
Gly Met Ala Ser Gly Arg Thr Glu Ala Gln Ser Trp Lys Ser Gln Asp
145                 150                 155                 160 
Thr Lys Thr Thr Gln Gly Asn Gly Gly Gln Thr Arg Lys Leu Thr Ala
                165                 170                 175     
Ser Arg Thr Val Ser Glu Lys His Gln Gly Lys Ala Ala Thr Thr Ala
            180                 185                 190         
Lys Thr Leu Ile Pro Lys Ser Gln His Arg Met Leu Ala Pro Thr Gly
        195                 200                 205             
Ala Val Ser Thr Arg Thr Arg Gln Lys Gly Val Thr Thr Ala Val Ile
    210                 215                 220                 
Pro Pro Lys Glu Lys Lys Pro Gln Ala Thr Pro Pro Pro Ala Pro Phe
225                 230                 235                 240 
Gln Ser Pro Thr Thr Gln Arg Asn Gln Arg Leu Lys Ala Ala Asn Phe
                245                 250                 255     
Lys Ser Glu Pro Arg Trp Asp Phe Glu Glu Lys Tyr Ser Phe Glu Ile
            260                 265                 270         
Gly Gly Leu Gln Thr Thr Cys Pro Asp Ser Val Lys Ile Lys Ala Ser
        275                 280                 285             
Lys Ser Leu Trp Leu Gln Lys Leu Phe Leu Pro Asn Leu Thr Leu Phe
    290                 295                 300                 
Leu Asp Ser Arg His Phe Asn Gln Ser Glu Trp Asp Arg Leu Glu His
305                 310                 315                 320 
Phe Ala Pro Pro Phe Gly Phe Met Glu Leu Asn Tyr Ser Leu Val Gln
                325                 330                 335     
Lys Val Val Thr Arg Phe Pro Pro Val Pro Gln Gln Gln Leu Leu Leu
            340                 345                 350         
Ala Ser Leu Pro Ala Gly Ser Leu Arg Cys Ile Thr Cys Ala Val Val
        355                 360                 365             
Gly Asn Gly Gly Ile Leu Asn Asn Ser His Met Gly Gln Glu Ile Asp
    370                 375                 380                 
Ser His Asp Tyr Val Phe Arg Leu Ser Gly Ala Leu Ile Lys Gly Tyr
385                 390                 395                 400 
Glu Gln Asp Val Gly Thr Arg Thr Ser Phe Tyr Gly Phe Thr Ala Phe
                405                 410                 415     
Ser Leu Thr Gln Ser Leu Leu Ile Leu Gly Asn Arg Gly Phe Lys Asn
            420                 425                 430         
Val Pro Leu Gly Lys Asp Val Arg Tyr Leu His Phe Leu Glu Gly Thr
        435                 440                 445             
Arg Asp Tyr Glu Trp Leu Glu Ala Leu Leu Met Asn Gln Thr Val Met
    450                 455                 460                 
Ser Lys Asn Leu Phe Trp Phe Arg His Arg Pro Gln Glu Ala Phe Arg
465                 470                 475                 480 
Glu Ala Leu His Met Asp Arg Tyr Leu Leu Leu His Pro Asp Phe Leu
                485                 490                 495     
Arg Tyr Met Lys Asn Arg Phe Leu Arg Ser Lys Thr Leu Asp Gly Ala
            500                 505                 510         
His Trp Arg Ile Tyr Arg Pro Thr Thr Gly Ala Leu Leu Leu Leu Thr
        515                 520                 525             
Ala Leu Gln Leu Cys Asp Gln Val Ser Ala Tyr Gly Phe Ile Thr Glu
    530                 535                 540                 
Gly His Glu Arg Phe Ser Asp His Tyr Tyr Asp Thr Ser Trp Lys Arg
545                 550                 555                 560 
Leu Ile Phe Tyr Ile Asn His Asp Phe Lys Leu Glu Arg Glu Val Trp
                565                 570                 575     
Lys Arg Leu His Asp Glu Gly Ile Ile Arg Leu Tyr Gln Arg Pro Gly
            580                 585                 590         
Pro Gly Thr Ala Lys Ala Lys Asn
        595                 600 


<210> 2173
<211> 1857
<212> PRT
<213> Homo sapiens

<400> 2173
Met Glu Gln Leu Thr Thr Leu Pro Arg Pro Gly Asp Pro Gly Ala Met
 1               5                  10                  15      
Glu Pro Trp Ala Leu Pro Thr Trp His Ser Trp Thr Pro Gly Arg Gly
            20                  25                  30          
Gly Glu Pro Ser Ser Ala Ala Pro Ser Ile Ala Asp Thr Pro Pro Ala
        35                  40                  45              
Ala Leu Gln Leu Gln Glu Leu Arg Ser Glu Glu Ser Ser Lys Pro Lys
    50                  55                  60                  
Gly Asp Gly Ser Ser Arg Pro Val Gly Gly Thr Asp Pro Glu Gly Ala
65                  70                  75                  80  
Glu Ala Cys Leu Pro Ser Leu Gly Gln Gln Ala Ser Ser Ser Gly Pro
                85                  90                  95      
Ala Cys Gln Arg Pro Glu Asp Glu Glu Val Glu Ala Phe Leu Lys Ala
            100                 105                 110         
Lys Leu Asn Met Ser Phe Gly Asp Arg Pro Asn Leu Glu Leu Leu Arg
        115                 120                 125             
Ala Leu Gly Glu Leu Arg Gln Arg Cys Ala Ile Leu Lys Glu Glu Asn
    130                 135                 140                 
Gln Met Leu Arg Lys Ser Ser Phe Pro Glu Thr Glu Glu Lys Val Arg
145                 150                 155                 160 
Arg Leu Lys Arg Lys Asn Ala Glu Leu Ala Val Ile Ala Lys Arg Leu
                165                 170                 175     
Glu Glu Arg Ala Arg Lys Leu Gln Glu Thr Asn Leu Arg Val Val Ser
            180                 185                 190         
Ala Pro Leu Pro Arg Pro Gly Thr Ser Leu Glu Leu Cys Arg Lys Ala
        195                 200                 205             
Leu Ala Arg Gln Arg Ala Arg Asp Leu Ser Glu Thr Ala Ser Ala Leu
    210                 215                 220                 
Leu Ala Lys Asp Lys Gln Ile Ala Ala Leu Gln Arg Glu Cys Arg Glu
225                 230                 235                 240 
Leu Gln Ala Arg Leu Thr Leu Val Gly Lys Glu Gly Pro Gln Trp Leu
                245                 250                 255     
His Val Arg Asp Phe Asp Arg Leu Leu Arg Glu Ser Gln Arg Glu Val
            260                 265                 270         
Leu Arg Leu Gln Arg Gln Ile Ala Leu Arg Asn Gln Arg Glu Thr Leu
        275                 280                 285             
Pro Leu Pro Pro Ser Trp Pro Pro Gly Pro Ala Leu Gln Ala Arg Ala
    290                 295                 300                 
Gly Ala Pro Ala Pro Gly Ala Pro Gly Glu Ala Thr Pro Gln Glu Asp
305                 310                 315                 320 
Ala Asp Asn Leu Pro Val Ile Leu Gly Glu Pro Glu Lys Glu Gln Arg
                325                 330                 335     
Val Gln Gln Leu Glu Ser Glu Leu Ser Lys Lys Arg Lys Lys Cys Glu
            340                 345                 350         
Ser Leu Glu Gln Glu Ala Arg Lys Lys Gln Arg Arg Cys Glu Glu Leu
        355                 360                 365             
Glu Leu Gln Leu Arg Gln Ala Gln Asn Glu Asn Ala Arg Leu Val Glu
    370                 375                 380                 
Glu Asn Ser Arg Leu Ser Gly Arg Ala Thr Glu Lys Glu Gln Val Glu
385                 390                 395                 400 
Trp Glu Asn Ala Glu Leu Arg Gly Gln Leu Leu Gly Val Thr Gln Glu
                405                 410                 415     
Arg Asp Ser Ala Leu Arg Lys Ser Gln Gly Leu Gln Ser Lys Leu Glu
            420                 425                 430         
Ser Leu Glu Gln Val Leu Lys His Met Arg Glu Val Ala Gln Arg Arg
        435                 440                 445             
Gln Gln Leu Glu Val Glu His Glu Gln Ala Arg Leu Ser Leu Arg Glu
    450                 455                 460                 
Lys Gln Glu Glu Val Arg Arg Leu Gln Gln Ala Gln Ala Glu Ala Gln
465                 470                 475                 480 
Arg Glu His Glu Gly Ala Val Gln Leu Leu Glu Ser Thr Leu Asp Ser
                485                 490                 495     
Met Gln Ala Arg Val Arg Glu Leu Glu Glu Gln Cys Arg Ser Gln Thr
            500                 505                 510         
Glu Gln Phe Ser Leu Leu Ala Gln Glu Leu Gln Ala Phe Arg Leu His
        515                 520                 525             
Pro Gly Pro Leu Asp Leu Leu Thr Ser Ala Leu Asp Cys Gly Ser Leu
    530                 535                 540                 
Gly Asp Cys Pro Pro Pro Pro Cys Cys Cys Ser Ile Pro Gln Pro Cys
545                 550                 555                 560 
Arg Gly Ser Gly Pro Lys Asp Leu Asp Leu Pro Pro Gly Ser Pro Gly
                565                 570                 575     
Arg Cys Thr Pro Lys Ser Ser Glu Pro Ala Pro Ala Thr Leu Thr Gly
            580                 585                 590         
Val Pro Arg Arg Thr Ala Lys Lys Ala Glu Ser Leu Ser Asn Ser Ser
        595                 600                 605             
His Ser Glu Ser Ile His Asn Ser Pro Lys Ser Cys Pro Thr Pro Glu
    610                 615                 620                 
Val Asp Thr Ala Ser Glu Val Glu Glu Leu Glu Ala Asp Ser Val Ser
625                 630                 635                 640 
Leu Leu Pro Ala Ala Pro Glu Gly Ser Arg Gly Gly Ala Arg Ile Gln
                645                 650                 655     
Val Phe Leu Ala Arg Tyr Ser Tyr Asn Pro Phe Glu Gly Pro Asn Glu
            660                 665                 670         
Asn Pro Glu Ala Glu Leu Pro Leu Thr Ala Gly Glu Tyr Ile Tyr Ile
        675                 680                 685             
Tyr Gly Asn Met Asp Glu Asp Gly Phe Phe Glu Gly Glu Leu Met Asp
    690                 695                 700                 
Gly Arg Arg Gly Leu Val Pro Ser Asn Phe Val Glu Arg Val Ser Asp
705                 710                 715                 720 
Asp Asp Leu Leu Thr Ser Leu Pro Pro Glu Leu Ala Asp Leu Ser His
                725                 730                 735     
Ser Ser Gly Pro Glu Leu Ser Phe Leu Ser Val Gly Gly Gly Gly Ser
            740                 745                 750         
Ser Ser Gly Gly Gln Ser Ser Val Gly Arg Ser Gln Pro Arg Pro Glu
        755                 760                 765             
Glu Glu Asp Ala Gly Asp Glu Leu Ser Leu Ser Pro Ser Pro Glu Gly
    770                 775                 780                 
Leu Gly Glu Pro Pro Ala Val Pro Tyr Pro Arg Arg Leu Val Val Leu
785                 790                 795                 800 
Lys Gln Leu Ala His Ser Val Val Leu Ala Trp Glu Pro Pro Pro Glu
                805                 810                 815     
Gln Val Glu Leu His Gly Phe His Ile Cys Val Asn Gly Glu Leu Arg
            820                 825                 830         
Gln Ala Leu Gly Pro Gly Ala Pro Pro Lys Ala Val Leu Glu Asn Leu
        835                 840                 845             
Asp Leu Trp Ala Gly Pro Leu His Ile Ser Val Gln Ala Leu Thr Ser
    850                 855                 860                 
Arg Gly Ser Ser Asp Pro Leu Arg Cys Cys Leu Ala Val Gly Ala Arg
865                 870                 875                 880 
Ala Gly Val Val Pro Ser Gln Leu Arg Val His Arg Leu Thr Ala Thr
                885                 890                 895     
Ser Ala Glu Ile Thr Trp Val Pro Gly Asn Ser Asn Leu Ala His Ala
            900                 905                 910         
Ile Tyr Leu Asn Gly Glu Glu Cys Pro Pro Ala Ser Pro Ser Thr Tyr
        915                 920                 925             
Trp Ala Thr Phe Cys His Leu Arg Pro Gly Thr Pro Tyr Gln Ala Gln
    930                 935                 940                 
Val Glu Ala Gln Leu Pro Pro Gln Gly Pro Trp Glu Pro Gly Trp Glu
945                 950                 955                 960 
Arg Leu Glu Gln Arg Ala Ala Thr Leu Gln Phe Thr Thr Leu Pro Ala
                965                 970                 975     
Gly Pro Pro Asp Ala Pro Leu Asp Val Gln Ile Glu Pro Gly Pro Ser
            980                 985                 990         
Pro Gly Ile Leu Ile Ile Ser Trp Leu Pro Val Thr Ile Asp Ala Ala
        995                 1000                1005            
Gly Thr Ser Asn Gly Val Arg Val Thr Gly Tyr Ala Ile Tyr Ala Asp
    1010                1015                1020                
Gly Gln Lys Ile Met Glu Val Ala Ser Pro Thr Ala Gly Ser Val Leu
1025                1030                1035                1040
Val Glu Leu Ser Gln Leu Gln Leu Leu Gln Val Cys Arg Glu Val Val
                1045                1050                1055    
Val Arg Thr Met Ser Pro His Gly Glu Ser Ala Asp Ser Ile Pro Ala
            1060                1065                1070        
Pro Ile Thr Pro Ala Leu Ala Pro Ala Ser Leu Pro Ala Arg Val Ser
        1075                1080                1085            
Cys Pro Ser Pro His Pro Ser Pro Glu Ala Arg Ala Pro Leu Ala Ser
    1090                1095                1100                
Ala Ser Pro Gly Pro Gly Asp Pro Ser Ser Pro Leu Gln His Pro Ala
1105                1110                1115                1120
Pro Leu Gly Thr Gln Glu Pro Pro Gly Ala Pro Pro Ala Ser Pro Ser
                1125                1130                1135    
Arg Glu Met Ala Lys Gly Ser His Glu Asp Pro Pro Ala Pro Cys Ser
            1140                1145                1150        
Gln Glu Glu Ala Gly Ala Ala Val Leu Gly Thr Ser Glu Glu Arg Thr
        1155                1160                1165            
Ala Ser Thr Ser Thr Leu Gly Glu Lys Asp Pro Gly Pro Ala Ala Pro
    1170                1175                1180                
Ser Leu Ala Lys Gln Glu Ala Glu Trp Thr Ala Gly Glu Ala Cys Pro
1185                1190                1195                1200
Ala Ser Ser Ser Thr Gln Gly Ala Arg Ala Gln Gln Ala Pro Asn Thr
                1205                1210                1215    
Glu Met Cys Gln Gly Gly Asp Pro Gly Ser Gly Leu Arg Pro Arg Ala
            1220                1225                1230        
Glu Lys Glu Asp Thr Ala Glu Leu Gly Val His Leu Val Asn Ser Leu
        1235                1240                1245            
Val Asp His Gly Arg Asn Ser Asp Leu Ser Asp Ile Gln Glu Glu Glu
    1250                1255                1260                
Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Leu Gly Ser Arg Thr Cys
1265                1270                1275                1280
Ser Phe Gln Lys Gln Val Ala Gly Asn Ser Ile Arg Glu Asn Gly Ala
                1285                1290                1295    
Lys Ser Gln Pro Asp Pro Phe Cys Glu Thr Asp Ser Asp Glu Glu Ile
            1300                1305                1310        
Leu Glu Gln Ile Leu Glu Leu Pro Leu Gln Gln Phe Cys Ser Lys Lys
        1315                1320                1325            
Leu Phe Ser Ile Pro Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Glu
    1330                1335                1340                
Glu Glu Lys Ser Gly Ala Gly Cys Ser Ser Arg Asp Pro Gly Pro Pro
1345                1350                1355                1360
Glu Pro Ala Leu Leu Gly Leu Gly Cys Asp Ser Gly Gln Pro Arg Arg
                1365                1370                1375    
Pro Gly Gln Cys Pro Leu Ser Pro Glu Ser Ser Arg Ala Gly Asp Cys
            1380                1385                1390        
Leu Glu Asp Met Pro Gly Leu Val Gly Gly Ser Ser Arg Arg Arg Gly
        1395                1400                1405            
Gly Gly Ser Pro Glu Lys Pro Pro Ser Arg Arg Arg Pro Pro Asp Pro
    1410                1415                1420                
Arg Glu His Cys Ser Arg Leu Leu Ser Asn Asn Gly Pro Gln Ala Ser
1425                1430                1435                1440
Gly Arg Leu Gly Pro Thr Arg Glu Arg Gly Gly Leu Pro Val Ile Glu
                1445                1450                1455    
Gly Pro Arg Thr Gly Leu Glu Ala Ser Gly Arg Gly Arg Leu Gly Pro
            1460                1465                1470        
Ser Arg Arg Cys Ser Arg Gly Arg Ala Leu Glu Pro Gly Leu Ala Ser
        1475                1480                1485            
Cys Leu Ser Pro Lys Cys Leu Glu Ile Ser Ile Glu Tyr Asp Ser Glu
    1490                1495                1500                
Asp Glu Gln Glu Ala Gly Ser Gly Gly Ile Ser Ile Thr Ser Ser Cys
1505                1510                1515                1520
Tyr Pro Gly Asp Gly Glu Ala Trp Gly Thr Ala Thr Val Gly Arg Pro
                1525                1530                1535    
Arg Gly Pro Pro Lys Ala Asn Ser Gly Pro Lys Pro Tyr Pro Arg Leu
            1540                1545                1550        
Pro Ala Trp Glu Lys Gly Glu Pro Glu Arg Arg Gly Arg Ser Ala Thr
        1555                1560                1565            
Gly Arg Ala Lys Glu Pro Leu Ser Arg Ala Thr Glu Thr Gly Glu Ala
    1570                1575                1580                
Arg Gly Gln Asp Gly Ser Gly Arg Arg Gly Pro Gln Lys Arg Gly Val
1585                1590                1595                1600
Arg Val Leu Arg Pro Ser Thr Ala Glu Leu Val Pro Ala Arg Ser Pro
                1605                1610                1615    
Ser Glu Thr Leu Ala Tyr Gln His Leu Pro Val Arg Ile Phe Val Ala
            1620                1625                1630        
Leu Phe Asp Tyr Asp Pro Val Ser Met Ser Pro Asn Pro Asp Ala Gly
        1635                1640                1645            
Glu Glu Glu Leu Pro Phe Arg Glu Gly Gln Ile Leu Lys Val Phe Gly
    1650                1655                1660                
Asp Lys Asp Ala Asp Gly Phe Tyr Gln Gly Glu Gly Gly Gly Arg Thr
1665                1670                1675                1680
Gly Tyr Ile Pro Cys Asn Met Val Ala Glu Val Ala Val Asp Ser Pro
                1685                1690                1695    
Ala Gly Arg Gln Gln Leu Leu Gln Arg Gly Tyr Leu Ser Pro Asp Ile
            1700                1705                1710        
Leu Leu Glu Gly Ser Gly Asn Gly Pro Phe Val Tyr Ser Thr Ala His
        1715                1720                1725            
Thr Thr Gly Pro Pro Pro Lys Pro Arg Arg Ser Lys Lys Ala Glu Ser
    1730                1735                1740                
Glu Gly Pro Ala Gln Pro Cys Pro Gly Pro Pro Lys Leu Val Pro Ser
1745                1750                1755                1760
Ala Asp Leu Lys Ala Pro His Ser Met Val Ala Ala Phe Asp Tyr Asn
                1765                1770                1775    
Pro Gln Glu Ser Ser Pro Asn Met Asp Val Glu Ala Glu Leu Pro Phe
            1780                1785                1790        
Arg Ala Gly Asp Val Ile Thr Val Phe Gly Gly Met Asp Asp Asp Gly
        1795                1800                1805            
Phe Tyr Tyr Gly Glu Leu Asn Gly Gln Arg Gly Leu Val Pro Ser Asn
    1810                1815                1820                
Phe Leu Glu Gly Pro Gly Pro Glu Ala Gly Gly Leu Asp Arg Glu Pro
1825                1830                1835                1840
Arg Thr Pro Gln Ala Glu Ser Gln Arg Thr Arg Arg Arg Arg Val Gln
                1845                1850                1855    
Cys
    


<210> 2174
<211> 1203
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 1085, 1086, 1087, 1088, 1089, 1090, 1091, 1092, 1093, 1094,
1095, 1096, 1097, 1098, 1099, 1100, 1101, 1102, 1103, 1104,
1105, 1106, 1107, 1108, 1109, 1110, 1111, 1112, 1113, 1114,
1115, 1116, 1117, 1118, 1119, 1120
<223> Xaa = Any Amino Acid

<400> 2174
Met Gly Gly His Ser Tyr Gly Leu Gly His Pro Ala Leu His Gln Asn
 1               5                  10                  15      
Leu Pro Pro Gly Phe Pro Ala Ser Val Ala Gly Pro Val Pro Ser Val
            20                  25                  30          
Phe Pro Leu Pro Gln Asp Ala Pro Thr Gln Leu Val Ile Leu Pro Ser
        35                  40                  45              
Glu Pro Thr Pro His Ser Ala Pro His Ala Leu Ala Asp Val Met Asp
    50                  55                  60                  
Gln Ala Ser Leu Trp Pro Pro Met Tyr Gly Gly Arg Gly Pro Ala Ser
65                  70                  75                  80  
His Met Gln His Pro Gly Gln Leu Pro Val Tyr Ser Arg Pro Gln Leu
                85                  90                  95      
Leu Arg Gln Gln Glu Leu Tyr Ala Leu Gln Gln Gln Arg Ala Ala Gln
            100                 105                 110         
Phe Gln Arg Lys Pro Glu Asp Gln His Leu Asp Leu Glu Glu Pro Ala
        115                 120                 125             
Gln Glu Lys Ala Pro Lys Ser Thr His Lys Pro Val Ala Leu Thr Pro
    130                 135                 140                 
Thr Ala Pro Gly Ala Pro Ser Pro Ala Ala Gly Pro Thr Lys Leu Pro
145                 150                 155                 160 
Pro Cys Cys His Pro Pro Asp Pro Lys Pro Pro Ala Ser Ser Pro Thr
                165                 170                 175     
Pro Pro Pro Arg Pro Ser Ala Pro Cys Thr Leu Asn Val Cys Pro Ala
            180                 185                 190         
Ser Ser Pro Gly Pro Gly Ser Arg Val Arg Ser Ala Glu Glu Lys Asn
        195                 200                 205             
Gly Glu Gly Gln Gln Ser Thr Ala Asp Ile Ile Thr Ser Glu Pro Val
    210                 215                 220                 
Ala Arg Ala His Ser Val Ala His Ala Gly Leu Glu Phe Leu Ala Ser
225                 230                 235                 240 
Asn Asp Pro Ser Thr Ser Ala Ser Gln Ser Phe Gly Ile Thr Asp Leu
                245                 250                 255     
Pro Pro Gly Tyr Leu Arg Pro Met Ala Gly Leu Gly Phe Ser Leu Pro
            260                 265                 270         
Ser Asp Val His Ser Ser Asn Leu Glu Asp Pro Glu Thr Met Gln Thr
        275                 280                 285             
Thr Ala Pro Gly Ala Gln Pro Glu Pro Thr Arg Thr Phe Leu Pro Gly
    290                 295                 300                 
Glu Pro Pro Pro Cys Ser Pro Arg Ser Leu Glu Glu Pro Gly Leu Leu
305                 310                 315                 320 
Ser Gly Ala Arg Glu Ala Thr Gln Asp Leu Ala Ala Thr Pro Tyr Pro
                325                 330                 335     
Ala Glu Arg Gly Pro Gln Gly Lys Ala Ala Asp Pro Ser Pro Leu Glu
            340                 345                 350         
Gly Leu Gln Glu Leu Gln Cys Ala Ala Leu Leu Glu Ala Gly Gly Pro
        355                 360                 365             
Glu Ala Thr Gly Gln Ala His Ser Thr Gln Gly Gly Ala Arg Glu Glu
    370                 375                 380                 
Arg Ser Arg Glu Glu Gly Glu Gln Gly Pro Ser Ser Gly Ala Ser Ser
385                 390                 395                 400 
Gln Val Leu Glu Gln Arg Ala Gly Ser Pro Gly Ala Leu Glu Asp Glu
                405                 410                 415     
Gly Glu Gln Pro Ala Pro Glu Glu Asp Glu Leu Glu Glu Asp Glu Leu
            420                 425                 430         
Gly Gln Gln Ser Met Glu Asp Ser Glu Glu Asp Cys Gly Gly Ala Pro
        435                 440                 445             
Asp Asn Ser His Pro Pro Arg Ala Leu Pro Gly Leu Asp Ala Leu Val
    450                 455                 460                 
Ala Ala Thr Ile Asn Leu Gly Asp Leu Pro Ser Asp Ser Pro Pro Asp
465                 470                 475                 480 
Pro Gln Pro Pro Ala Ala Ser Gly Pro Pro Ser Thr Val Pro Leu Pro
                485                 490                 495     
His Ser Ser Gly Ile His Gly Ile Ala Leu Leu Ser Glu Leu Ala Asp
            500                 505                 510         
Leu Ala Ile Gln Arg Gln Arg Ser Glu Arg Thr Val Pro Glu Glu Glu
        515                 520                 525             
Glu Asp Val Leu Ser Phe Asn Leu Gln His Leu Ala Thr Leu Ala Thr
    530                 535                 540                 
Ala Trp Ser Leu Val Glu Ala Ala Gly Leu Asp Ser Ser Thr Ala Pro
545                 550                 555                 560 
Ala Gln Pro Pro Thr Ala Asn Pro Cys Ser Gly Pro Arg Leu Thr Pro
                565                 570                 575     
Arg Met Gln Ile Leu Gln Arg Lys Asp Thr Trp Thr Pro Lys Thr Lys
            580                 585                 590         
Pro Val Cys Pro Leu Lys Ala Ala Ile Asp Gln Leu Asp Thr Gln Glu
        595                 600                 605             
Val Gly Met Arg Val Arg Leu Ala Glu Leu Gln Arg Arg Tyr Lys Glu
    610                 615                 620                 
Lys Gln Arg Glu Leu Ala Arg Leu Gln Arg Lys His Asp His Glu Arg
625                 630                 635                 640 
Asp Glu Ser Ser Arg Ser Pro Ala Arg Arg Gly Pro Gly Arg Pro Arg
                645                 650                 655     
Lys Arg Lys His Ser Ser Ser Leu Pro Ala Pro Arg Pro Thr Gly Pro
            660                 665                 670         
Leu Pro Arg Ser Asp Gly Lys Lys Val Lys Ala Val Arg Thr Ser Leu
        675                 680                 685             
Gly Leu Leu Cys Ala Glu Leu Arg Gly Gly Ser Gly Gly Glu Pro Ala
    690                 695                 700                 
Lys Lys Arg Ser Lys Leu Glu Arg Ser Val Tyr Ala Gly Leu Gln Thr
705                 710                 715                 720 
Ala Ser Val Glu Lys Ala Gln Cys Lys Lys Ser Ser Cys Gln Gly Gly
                725                 730                 735     
Leu Ala Pro Ser Val Ala His Arg Val Ala Gln Leu Lys Pro Lys Val
            740                 745                 750         
Lys Ser Lys Gly Leu Pro Thr Gly Leu Ser Ser Phe Gln Gln Lys Glu
        755                 760                 765             
Ala Thr Pro Gly Gly Arg Ile Arg Glu Lys Leu Ser Arg Ala Lys Ser
    770                 775                 780                 
Ala Lys Val Ser Gly Ala Thr Arg His Pro Gln Pro Lys Gly His Gly
785                 790                 795                 800 
Ser Arg Glu Thr Pro Arg Cys Pro Ala Gln Pro Ser Val Ala Ala Ser
                805                 810                 815     
Gln Glu Ala Gly Ser Gly Tyr Asp Ser Glu Asp Cys Glu Gly Leu Leu
            820                 825                 830         
Gly Thr Glu Ala Pro Pro Arg Glu Ala Gly Leu Leu Leu His Ala Gly
        835                 840                 845             
Ala Ser Val Ala Val Leu Gly Pro Ser Pro Ser Ser Val Val Lys Met
    850                 855                 860                 
Glu Ala Asn His Gln Ala Glu Lys Lys Lys Glu Arg Gln Gly Leu Leu
865                 870                 875                 880 
Gly Ala Cys Arg Leu Ser Ser Pro Glu Ser Glu Val Lys Ile Lys Arg
                885                 890                 895     
Arg Ser Val Lys Ala Lys Val Gly Thr Thr Leu Glu Arg Ala Pro Gly
            900                 905                 910         
Gln Arg Pro Pro Gly Ala Leu Gly Lys Lys Lys Ala Lys Gly Lys Ala
        915                 920                 925             
Lys Gly Ser Leu Arg Ala Glu Pro Gly Ala Thr Pro Ser Arg Asp Ala
    930                 935                 940                 
Leu Phe Asn Pro Ser Arg Ala Phe Ala Cys Arg Glu Glu Gly Ser Gln
945                 950                 955                 960 
Leu Ala Ser Glu Arg Leu Lys Arg Ala Thr Arg Lys Gly Thr Val Leu
                965                 970                 975     
Gln Pro Val Leu Arg Arg Lys Asn Gly Ala Leu Ser Ile Thr Leu Ala
            980                 985                 990         
Thr Arg Asn Ala Lys Ala Ile Leu Gly Lys Gly Arg Lys Leu Ser Lys
        995                 1000                1005            
Val Lys His Lys Ala Gly Lys Gln Gly Lys Gly Arg Ala Val Ser Arg
    1010                1015                1020                
Leu Leu Glu Ser Phe Ala Val Glu Glu Asp Phe Glu Phe Asp Asp Asn
1025                1030                1035                1040
Ser Ser Phe Ser Glu Glu Glu Glu Asp Glu Glu Glu Glu Glu Glu Asp
                1045                1050                1055    
Ser Gly Pro Leu Ser Ala Glu Gln Ser Ala Ala Leu Ala Arg Ser Cys
            1060                1065                1070        
Ala Ile His Lys Glu Asp Leu Arg Asp Gly Leu Pro Xaa Xaa Xaa Xaa
        1075                1080                1085            
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    1090                1095                1100                
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
1105                1110                1115                1120
Arg Ile Tyr Ser Leu Asn Gln Leu Leu Gln Glu Ala Val Leu Asp Val
                1125                1130                1135    
Arg Pro Gln Ser Ser Arg Tyr Leu Pro Pro Gly Thr Arg Val Cys Ala
            1140                1145                1150        
Tyr Trp Ser Gln Lys Ser Arg Cys Leu Tyr Pro Gly Asn Val Val Arg
        1155                1160                1165            
Gly Ala Ser Gly Asp Glu Asp Glu Asp Leu Asp Ser Val Val Val Glu
    1170                1175                1180                
Phe Asp Asp Gly Asp Thr Gly His Ile Ala Val Ser Arg Arg Gln Ala
1185                1190                1195                1200
Ala Ala Pro
            


<210> 2175
<211> 851
<212> PRT
<213> Homo sapiens

<400> 2175
Met Pro Val Val Arg Gly Gly Gln Thr Val Pro Gly Gln Ala Pro Leu
 1               5                  10                  15      
Cys Phe Asp Pro Gly Ser Pro Ala Ser Asp Lys Thr Glu Gly Lys Lys
            20                  25                  30          
Lys Gly Arg Pro Lys Ala Glu Asn Gln Ala Leu Arg Asp Ile Pro Leu
        35                  40                  45              
Ser Leu Met Asn Asp Trp Lys Asp Glu Phe Lys Ala His Ser Arg Val
    50                  55                  60                  
Lys Cys Pro Asn Ser Gly Cys Trp Leu Glu Phe Pro Ser Ile Tyr Gly
65                  70                  75                  80  
Leu Lys Tyr His Tyr Gln Arg Cys Gln Gly Gly Ala Ile Ser Asp Arg
                85                  90                  95      
Leu Ala Phe Pro Cys Pro Phe Cys Glu Ala Ala Phe Thr Ser Lys Thr
            100                 105                 110         
Gln Leu Glu Lys His Arg Ile Trp Asn His Met Asp Arg Pro Leu Pro
        115                 120                 125             
Ala Ser Lys Pro Gly Pro Ile Ser Arg Pro Val Thr Ile Ser Arg Pro
    130                 135                 140                 
Val Gly Val Ser Lys Pro Ile Gly Val Ser Lys Pro Val Thr Ile Gly
145                 150                 155                 160 
Lys Pro Val Gly Val Ser Lys Pro Ile Gly Ile Ser Lys Pro Val Ser
                165                 170                 175     
Val Gly Arg Pro Met Pro Val Thr Lys Ala Ile Pro Val Thr Arg Pro
            180                 185                 190         
Val Pro Val Thr Lys Pro Val Thr Val Ser Arg Pro Met Pro Val Thr
        195                 200                 205             
Lys Ala Met Pro Val Thr Lys Pro Ile Thr Val Thr Lys Ser Val Pro
    210                 215                 220                 
Val Thr Lys Pro Val Pro Val Thr Lys Pro Ile Thr Val Thr Lys Leu
225                 230                 235                 240 
Val Thr Val Thr Lys Pro Val Pro Val Thr Lys Pro Val Thr Val Ser
                245                 250                 255     
Arg Pro Ile Val Val Ser Lys Pro Val Thr Val Ser Arg Pro Ile Ala
            260                 265                 270         
Ile Ser Arg His Thr Pro Pro Cys Lys Met Val Leu Leu Thr Arg Ser
        275                 280                 285             
Glu Asn Lys Ala Pro Arg Ala Thr Gly Arg Asn Ser Gly Lys Lys Arg
    290                 295                 300                 
Ala Ala Asp Ser Leu Asp Thr Cys Pro Ile Pro Pro Lys Gln Ala Arg
305                 310                 315                 320 
Pro Glu Asn Gly Glu Tyr Gly Pro Ser Ser Met Gly Gln Ser Ser Ala
                325                 330                 335     
Phe Gln Leu Ser Ala Asp Thr Ser Ser Gly Ser Leu Ser Pro Gly Ser
            340                 345                 350         
Arg Pro Ser Gly Gly Met Glu Ala Leu Lys Ala Ala Gly Pro Ala Ser
        355                 360                 365             
Pro Pro Glu Glu Asp Pro Glu Arg Thr Lys His Arg Arg Lys Gln Lys
    370                 375                 380                 
Thr Pro Lys Lys Phe Thr Gly Glu Gln Pro Ser Ile Ser Gly Thr Phe
385                 390                 395                 400 
Gly Leu Lys Gly Leu Val Lys Ala Glu Asp Lys Ala Arg Val His Arg
                405                 410                 415     
Ser Lys Lys Gln Glu Gly Pro Gly Pro Glu Asp Ala Arg Lys Lys Val
            420                 425                 430         
Pro Ala Ala Pro Ile Thr Val Ser Lys Glu Ala Pro Ala Pro Val Ala
        435                 440                 445             
His Pro Ala Pro Gly Gly Pro Glu Glu Gln Trp Gln Arg Ala Ile His
    450                 455                 460                 
Glu Arg Gly Glu Ala Val Cys Pro Thr Cys Asn Val Val Thr Arg Lys
465                 470                 475                 480 
Thr Leu Val Gly Leu Lys Lys His Met Glu Val Cys Gln Lys Leu Gln
                485                 490                 495     
Asp Ala Leu Lys Cys Gln His Cys Arg Lys Gln Phe Lys Ser Lys Ala
            500                 505                 510         
Gly Leu Asn Tyr His Thr Met Ala Glu His Ser Ala Lys Pro Ser Asp
        515                 520                 525             
Ala Glu Ala Ser Glu Gly Gly Glu Gln Glu Glu Arg Glu Arg Leu Arg
    530                 535                 540                 
Lys Val Leu Lys Gln Met Gly Arg Leu Arg Cys Pro Gln Glu Gly Cys
545                 550                 555                 560 
Gly Ala Ala Phe Ser Ser Leu Met Gly Tyr Gln Tyr His Gln Arg Arg
                565                 570                 575     
Cys Gly Lys Pro Pro Cys Glu Val Asp Ser Pro Ser Phe Pro Cys Thr
            580                 585                 590         
His Cys Gly Lys Thr Tyr Arg Ser Lys Ala Gly His Asp Tyr His Val
        595                 600                 605             
Arg Ser Glu His Thr Ala Pro Pro Pro Glu Glu Pro Thr Asp Lys Ser
    610                 615                 620                 
Pro Glu Ala Glu Asp Pro Leu Gly Val Glu Arg Thr Pro Ser Gly Arg
625                 630                 635                 640 
Val Arg Arg Thr Ser Ala Gln Val Ala Val Phe His Leu Gln Glu Ile
                645                 650                 655     
Ala Glu Asp Glu Leu Ala Arg Asp Trp Thr Lys Arg Arg Met Lys Asp
            660                 665                 670         
Asp Leu Val Pro Glu Thr Ala Arg Leu Asn Tyr Thr Arg Pro Gly Leu
        675                 680                 685             
Pro Thr Leu Asn Pro Gln Leu Leu Glu Ala Trp Lys Asn Glu Val Lys
    690                 695                 700                 
Glu Lys Gly His Val Asn Cys Pro Asn Asp Cys Cys Glu Ala Ile Tyr
705                 710                 715                 720 
Ser Ser Val Ser Gly Leu Lys Ala His Leu Ala Ser Cys Ser Lys Gly
                725                 730                 735     
Ala His Leu Ala Gly Lys Tyr Arg Cys Leu Leu Cys Pro Lys Glu Phe
            740                 745                 750         
Ser Ser Glu Ser Gly Val Lys Tyr His Ile Leu Lys Thr His Ala Glu
        755                 760                 765             
Asn Trp Phe Arg Thr Ser Ala Asp Pro Pro Pro Lys His Arg Ser Gln
    770                 775                 780                 
Asp Ser Leu Val Pro Lys Lys Glu Lys Lys Lys Asn Leu Ala Gly Gly
785                 790                 795                 800 
Lys Lys Arg Gly Arg Lys Pro Lys Glu Arg Thr Pro Glu Glu Pro Val
                805                 810                 815     
Ala Lys Leu Pro Pro Arg Arg Asp Asp Trp Pro Pro Gly Cys Arg Asp
            820                 825                 830         
Lys Gly Ala Arg Gly Ser Thr Gly Arg Lys Val Gly Val Ser Lys Ala
        835                 840                 845             
Pro Glu Lys
    850     


<210> 2176
<211> 918
<212> PRT
<213> Homo sapiens

<400> 2176
Met Asn Glu Asn Met Arg Ala Thr Leu Ala Thr Ser Lys Asn Val Phe
 1               5                  10                  15      
Gln Leu Lys Leu Glu Glu Thr Gln Lys Leu Leu Glu Asp Gln His Leu
            20                  25                  30          
Ser Asn Leu Gln Lys Phe Gly Asp Glu Val Asn Gln Ile Thr Asn Ser
        35                  40                  45              
Glu Thr Leu Ser Ser Ile Asp Ser Leu Glu Ala Thr Glu His Glu Glu
    50                  55                  60                  
Ile Tyr Leu Thr Leu Asn Lys Glu His Ser Thr Ser Ile Gln Arg Asn
65                  70                  75                  80  
Thr Ile Ser Leu Lys Pro Ala Asn Met Gln Ser Thr Asn Leu Ser Cys
                85                  90                  95      
Phe Asp Glu Asp Lys Leu Ala Phe Ser Lys Thr Gln His Ile Asn Asn
            100                 105                 110         
Trp Leu Thr Asn Leu Asp Ala Ser Asn Thr Gln Asn Val Thr Ala Phe
        115                 120                 125             
Ser Asp Ile Leu Ser Lys Ser Asn Val Leu Pro Ser Trp Glu Tyr Phe
    130                 135                 140                 
Asn Ser Lys Glu Gln Asn Pro Ser Pro Leu Asn Gly Thr Val Glu Arg
145                 150                 155                 160 
Ala Thr Asn Thr Ala Asn Asn Ser Val Pro Phe Val Ser Ser Pro Pro
                165                 170                 175     
Met Phe Val Leu Asp Lys Lys Cys Glu Lys Thr Ser Glu Thr Ser Thr
            180                 185                 190         
Met Arg Thr Thr Asp Ser Thr Ser Gly Ala Phe Lys Arg Glu Arg Pro
        195                 200                 205             
Leu Val Thr Glu Ser Pro Thr Phe Lys Phe Ser Lys Ser Gln Ser Thr
    210                 215                 220                 
Ser Asp Ser Leu Thr Gln Glu Val Ala Thr Phe Pro Asp Gln Glu Lys
225                 230                 235                 240 
Tyr Ser Glu Leu Asn Gln Glu Asn Gly Thr Thr Ser Ile Pro Thr Ser
                245                 250                 255     
Cys Val Pro Val Ala Thr Pro Leu Val Leu Pro Ser Asn Ile Gln Ser
            260                 265                 270         
Ala Arg Pro Ser Ala Lys Asn Ser Ile His Ile Lys Glu Ile Asp Ala
        275                 280                 285             
Val Gln Cys Ser Asp Lys Leu Asp Glu Leu Lys Asp Gly Lys Glu Glu
    290                 295                 300                 
Glu Ile Lys Tyr Phe Asn Cys Asn Lys Glu Glu Leu Pro Leu Phe Ser
305                 310                 315                 320 
Asp Ser Phe Gln Asp Ala Tyr Ile Pro His Asn Pro Asp Ser Lys Asp
                325                 330                 335     
Glu Lys Gln Lys Leu Ala Glu Thr Ser Ser Leu Ser Asn Val Thr Ser
            340                 345                 350         
Asn Tyr Asp Phe Val Gly Gln His Lys Lys Met Lys Tyr Asn Ile His
        355                 360                 365             
Glu Arg Asn Gly Val Arg Phe Leu Lys Ser Ile Leu Lys Lys Glu Ser
    370                 375                 380                 
Lys Tyr Glu His Gly Tyr Leu Lys Ala Leu Ile Ile Asn Gln Ser Phe
385                 390                 395                 400 
Lys Phe Gly Asn Gln Lys Ala Ala Ala Ile Arg Asp Ser Ile Glu Leu
                405                 410                 415     
Thr Lys Glu Lys Gly Ala Glu Ile Pro Lys Thr Ile Lys Lys Leu Arg
            420                 425                 430         
Trp Phe Asp Glu Thr Ser Asn Ile Glu Asn Asn Ala Glu Asn Ser His
        435                 440                 445             
Ser Leu Lys Asn Lys Thr Gly Thr Thr Gln Gln His Ser Gln Gln Phe
    450                 455                 460                 
His Ile Gln Ser Gly Ala Gly Ser Asn Ile Ile Ser Val Ser Thr Cys
465                 470                 475                 480 
Ala Val Asn Ser Ala Asp Thr Lys Lys Ser Arg Glu Asp Ser Ile Ser
                485                 490                 495     
Glu Asn Val Thr Thr Leu Gly Gly Ser Gly Ala Asp His Met Pro Leu
            500                 505                 510         
Asn Cys Phe Ile Pro Ser Gly Tyr Asn Phe Ala Lys His Ala Trp Pro
        515                 520                 525             
Ala Ser Lys Lys Glu Glu Ser Lys Ile Pro Val His Asp Asp Ser Lys
    530                 535                 540                 
Thr Lys Gln Gly Lys Pro Gln Arg Gly Arg Ala Lys Ile Ile Arg Lys
545                 550                 555                 560 
Pro Gly Ser Ala Lys Val Gln Ser Gly Phe Ile Cys Thr Asn Arg Lys
                565                 570                 575     
Gly Ala Val Ile Gln Pro Gln Ser Ala Ser Lys Val Asn Ile Phe Thr
            580                 585                 590         
Gln Ala Gln Gly Lys Leu Ile Ile Pro Cys Pro Pro Pro Gln Ser Thr
        595                 600                 605             
Ser Asn Ile Arg Ser Gly Lys Asn Ile Gln Val Ser Gln Cys Gln Pro
    610                 615                 620                 
Val Thr Pro Glu Asn Pro Gln Asn Ile Ile Thr His Asn Ser Phe Asn
625                 630                 635                 640 
Ser Lys His Val Leu Pro Thr Glu His Ser Leu Asn Gln Trp Asn Gln
                645                 650                 655     
Glu Ser Ser Ser Pro Leu Ser Asn Ala Cys Ser Asp Leu Val Thr Val
            660                 665                 670         
Ile Pro Ser Leu Pro Ser Tyr Cys Ser Ser Glu Cys Gln Thr Phe Ala
        675                 680                 685             
Lys Ile Asn His Ser Asn Gly Thr Gln Ala Val Ala Arg Gln Asp Ala
    690                 695                 700                 
Thr Leu Tyr Cys Thr Gln Arg Ser Pro Val Cys Glu Glu Ser Tyr Pro
705                 710                 715                 720 
Ser Val Thr Leu Arg Thr Ala Glu Glu Glu Ser Val Pro Leu Trp Lys
                725                 730                 735     
Arg Gly Pro Asn Val Leu His Gln Asn Lys Arg Ala Thr Gly Ser Thr
            740                 745                 750         
Val Met Arg Arg Lys Arg Ile Ala Glu Thr Lys Arg Arg Asn Ile Leu
        755                 760                 765             
Glu Gln Lys Arg Gln Asn Pro Gly Ser Val Gly Gln Lys Tyr Ser Glu
    770                 775                 780                 
Gln Ile Asn Asn Phe Gly Gln Ser Val Leu Leu Ser Ser Ser Glu Pro
785                 790                 795                 800 
Lys Gln Thr Thr Arg Gly Thr Ser Tyr Ile Glu Glu Val Ser Asp Ser
                805                 810                 815     
Thr Ser Glu Phe Leu Met Ala Glu Asn Leu Val Lys Ala Ser Val Pro
            820                 825                 830         
Glu Asp Glu Ile Leu Thr Val Leu Asn Ser Lys Gln Ile Gln Lys Ser
        835                 840                 845             
Asn Leu Pro Leu Asn Lys Thr Gln Gln Phe Asn Ile Cys Thr Leu Ser
    850                 855                 860                 
Ala Glu Glu Gln Lys Ile Leu Glu Ser Leu Asn Asp Leu Ser Glu Arg
865                 870                 875                 880 
Leu His Tyr Ile Gln Glu Ser Ile Cys Lys Asn Pro Ser Ile Lys Asn
                885                 890                 895     
Thr Leu Gln Ile Ile Pro Leu Leu Glu Lys Arg Glu Asp Arg Thr Ser
            900                 905                 910         
Ser Cys Arg Asp Lys Arg
        915             


<210> 2177
<211> 1191
<212> PRT
<213> Homo sapiens

<400> 2177
Met Glu Ala Met Ser Pro Gln Gln Glu Thr Leu Gly Gly Gln Pro Gly
 1               5                  10                  15      
Arg Ser Ser Ser Leu Thr Gly Val Ser Arg Leu Ala Gly Gly Ser Cys
            20                  25                  30          
Thr Lys Lys Lys Met Lys Thr Leu Ala Glu Arg Arg Arg Ser Ala Pro
        35                  40                  45              
Ser Leu Ile Leu Asp Lys Ala Leu Gln Lys Arg Pro Thr Thr Arg Asp
    50                  55                  60                  
Ser Pro Ser Ala Ser Val Asp Thr Cys Thr Phe Leu Ser Ser Leu Val
65                  70                  75                  80  
Cys Ser Asn Arg Thr Leu Leu Ile Asp Gly Arg Ala Glu Leu Lys Arg
                85                  90                  95      
Gly Leu Gln Arg Gln Glu Arg His Leu Phe Leu Phe Asn Asp Leu Phe
            100                 105                 110         
Val Val Ala Lys Ile Lys Tyr Asn Asn Asn Phe Lys Ile Lys Asn Lys
        115                 120                 125             
Ile Lys Leu Thr Asp Met Trp Thr Ala Ser Cys Val Asp Glu Val Gly
    130                 135                 140                 
Glu Gly Asn Thr Asn Ala Met Lys Ser Phe Val Leu Gly Trp Pro Thr
145                 150                 155                 160 
Val Asn Phe Val Ala Thr Phe Ser Ser Pro Glu Gln Lys Asp Lys Trp
                165                 170                 175     
Leu Ser Leu Leu Gln Arg Tyr Ile Asn Leu Glu Lys Glu Lys Asp Tyr
            180                 185                 190         
Pro Lys Ser Ile Pro Leu Lys Ile Phe Ala Lys Asp Ile Gly Asn Cys
        195                 200                 205             
Ala Tyr Ser Lys Thr Ile Thr Val Met Asn Ser Asp Thr Ala Asn Glu
    210                 215                 220                 
Val Ile Asn Met Ser Leu Pro Met Leu Gly Ile Thr Gly Ser Glu Arg
225                 230                 235                 240 
Asp Tyr Gln Leu Trp Val Asn Ser Gly Lys Glu Glu Ala Pro Tyr Pro
                245                 250                 255     
Leu Ile Gly His Glu Tyr Pro Tyr Gly Ile Lys Met Ser His Leu Arg
            260                 265                 270         
Asp Ser Ala Leu Leu Thr Pro Gly Ser Lys Asp Ser Thr Thr Pro Phe
        275                 280                 285             
Asn Leu Gln Glu Pro Phe Leu Met Glu Gln Leu Pro Arg Glu Met Gln
    290                 295                 300                 
Cys Gln Phe Ile Leu Lys Pro Ser Arg Leu Ala Ala Ala Gln Gln Leu
305                 310                 315                 320 
Ser Asp Ser Gly His Lys Thr Phe Lys Arg Arg Arg Ser Ile Ile Asn
                325                 330                 335     
Trp Ala Phe Trp Arg Gly Ser Ser Thr His Leu Asp Asn Leu Pro Ser
            340                 345                 350         
Ser Pro Thr Ser Pro Met Pro Gly Gln Leu Phe Gly Ile Ser Leu Pro
        355                 360                 365             
Asn Ile Cys Glu Asn Asp Asn Leu Pro Lys Pro Val Leu Asp Met Leu
    370                 375                 380                 
Phe Phe Leu Asn Gln Lys Gly Pro Leu Thr Lys Gly Ile Phe Arg Gln
385                 390                 395                 400 
Ser Ala Asn Val Lys Ser Cys Arg Glu Leu Lys Glu Lys Leu Asn Ser
                405                 410                 415     
Gly Val Glu Val His Leu Asp Cys Glu Ser Ile Phe Val Ile Ala Ser
            420                 425                 430         
Val Leu Lys Asp Phe Leu Arg Asn Ile Pro Gly Ser Ile Phe Ser Ser
        435                 440                 445             
Asp Leu Tyr Asp His Trp Val Ser Val Met Asp Gln Gly Asn Asp Glu
    450                 455                 460                 
Glu Lys Ile Asn Thr Val Gln Arg Leu Leu Asp Gln Leu Pro Arg Ala
465                 470                 475                 480 
Asn Val Val Leu Leu Arg Tyr Leu Phe Gly Val Leu His Asn Ile Glu
                485                 490                 495     
Gln His Ser Ser Ser Asn Gln Met Thr Ala Phe Asn Leu Ala Val Cys
            500                 505                 510         
Val Ala Pro Ser Ile Leu Trp Pro Pro Ala Ser Ser Ser Pro Glu Leu
        515                 520                 525             
Glu Asn Glu Phe Thr Lys Lys Val Ser Leu Leu Ile Gln Phe Leu Ile
    530                 535                 540                 
Glu Asn Cys Leu Arg Ile Phe Gly Glu Glu Ile Thr Ser Leu Phe Arg
545                 550                 555                 560 
Glu Val Ser Val Arg Cys Asp Thr Arg Glu Asn Ala Ser Asp Ile Ser
                565                 570                 575     
Cys Phe Gln Leu Asn Asp Ser Ser Tyr Asp Ser Leu Glu Asn Glu Leu
            580                 585                 590         
Asn Glu Asp Val Asp Ala Pro Cys Ser Asp Leu Val Lys Lys Leu Gly
        595                 600                 605             
Gln Gly Ser Arg Ser Met Asp Ser Val Leu Thr Leu Ser Asp Tyr Asp
    610                 615                 620                 
Leu Asp Gln Pro Glu Val Glu Gly Leu Leu Thr Leu Ser Asp Phe Asp
625                 630                 635                 640 
Leu Ala His Ser Lys Asp Glu Asp Val Gln Met Lys Arg Pro Leu Glu
                645                 650                 655     
Ser Lys Pro Val Asn Ile Leu Val Tyr Thr Lys Ile Pro Leu Arg Asp
            660                 665                 670         
His Ala Arg Ala Pro Ser Ala Met Cys Thr Pro Ser Tyr Leu Ser Thr
        675                 680                 685             
Ala Ala Ala Asn Ala Ala Lys Ser Leu Arg Arg His Arg Arg Cys Ser
    690                 695                 700                 
Glu Pro Ser Ile Asp Tyr Leu Asp Ser Lys Leu Ser Tyr Leu Arg Glu
705                 710                 715                 720 
Phe Tyr Gln Lys Lys Leu Arg Lys Ser Ser Cys Asp Ala Ile Leu Ser
                725                 730                 735     
Gln Lys Asp Glu Asp Tyr Leu Lys Gln Asn Gln Pro Leu Gln Glu Glu
            740                 745                 750         
Gly Lys Thr Cys Phe Lys Gln Ser Leu Val Thr Gly Thr Asp Val Ser
        755                 760                 765             
Lys Lys Asn Ala Thr Thr Gln Asn Thr Lys Lys Lys Ser Leu Ser Gly
    770                 775                 780                 
Ser Glu Gly Asn His Val Lys Leu Phe Pro Lys Ser Lys Pro Val Ala
785                 790                 795                 800 
Ile Ser Val Ala Ser Tyr Ser Pro Met Ser Ser Gln Asp His Ser Lys
                805                 810                 815     
Asn Gln Pro Phe Asp Val Asn Thr Ser Gly Tyr Ser Pro Pro His Thr
            820                 825                 830         
Ala Asp Ala Leu Lys Gly Pro Arg Thr His Arg Arg Cys Ser Glu Pro
        835                 840                 845             
Asn Ile Glu Asp Gln Asn Arg Lys Leu Thr Tyr Leu Arg Gly Ile Tyr
    850                 855                 860                 
Ser Lys Lys Gln His Lys Thr Ser Cys Glu Ala Gly Leu Leu His Gly
865                 870                 875                 880 
Glu Glu Asp Tyr Leu Lys Arg His Lys Ser Leu Gln Met Glu Gly Gln
                885                 890                 895     
Lys Leu Ile Asn Gln Ser Leu Val Met Gly Ile Glu Val Gly Lys Ser
            900                 905                 910         
Ser Ala Thr Asn Gln Asn Thr Glu Lys Val Leu Pro Pro Arg Leu Asn
        915                 920                 925             
Leu Cys Pro Arg Thr Ser Tyr Ser Ser Leu Ser Ser Pro Gly Thr Ser
    930                 935                 940                 
Pro Ser Gly Ser Ser Val Ser Ser Gln Asp Ser Ala Phe Ser Gln Ile
945                 950                 955                 960 
Ser Glu His Ser Val Phe Thr Pro Thr Glu Thr Ser Ser Pro Ile Asp
                965                 970                 975     
Cys Thr Phe Gln Ala Gln Arg Lys Arg Glu Asp Leu Ser Pro Asp Phe
            980                 985                 990         
Ser Asn Ala Ser His Val Ser Gly Met Pro Gly Pro Ser Ser Gly Gln
        995                 1000                1005            
Ala Cys Ser Arg Pro Ala Tyr Thr Lys Lys Asp Thr Met Glu Trp His
    1010                1015                1020                
Ser Gln Met His Ser Val Thr Leu His Pro Ser Thr Trp Leu Arg Asn
1025                1030                1035                1040
Gly Val Ala Ser Leu Lys Asn Trp Ser Leu Lys Lys Lys Ala Lys Ala
                1045                1050                1055    
Ala Arg Pro Glu Glu Glu Lys Ile Ala Ser Pro Lys Gly Pro Leu Glu
            1060                1065                1070        
Pro Pro Pro His Ala Ser Gly Val Pro Glu Ala Asn Ser Leu Gln Glu
        1075                1080                1085            
Glu Gln Lys Asp Leu Pro Leu Arg Ala Ala Glu Gly Leu Ser Pro Val
    1090                1095                1100                
Gln Ser Ala Gln Arg Cys Ser Ser Ser Pro Phe Gln Asp Ser Glu Arg
1105                1110                1115                1120
His Cys Ser Ser Pro Phe Ser Leu Val Glu Ser Arg Leu Lys Leu Cys
                1125                1130                1135    
Met Lys Ser His Glu Glu Ile Glu Pro Gly Ser Gln Ser Ser Ser Gly
            1140                1145                1150        
Ser Leu Pro Trp Glu Arg Ala Ser Ala Ser Ser Trp Thr Leu Glu Asp
        1155                1160                1165            
Ala Thr Ser Pro Asp Ser Gly Pro Thr Val Val Cys Asp Ile Glu Asp
    1170                1175                1180                
Arg Tyr Leu Thr Lys Asp Ile
1185                1190    


<210> 2178
<211> 790
<212> PRT
<213> Homo sapiens

<400> 2178
Met Ser Ser Lys Ala Glu Lys Lys Gln Arg Leu Ser Gly Arg Gly Ser
 1               5                  10                  15      
Ser Gln Ala Ser Trp Ser Gly Arg Ala Thr Arg Ala Ala Val Ala Thr
            20                  25                  30          
Gln Glu Gln Gly Asn Ala Pro Ala Val Ser Glu Pro Glu Leu Gln Ala
        35                  40                  45              
Glu Leu Pro Lys Glu Glu Pro Glu Pro Arg Leu Glu Gly Pro Gln Ala
    50                  55                  60                  
Gln Ser Glu Glu Ser Val Glu Pro Glu Ala Asp Val Lys Pro Leu Phe
65                  70                  75                  80  
Leu Ser Arg Ala Ala Leu Thr Gly Leu Ala Asp Ala Val Trp Thr Gln
                85                  90                  95      
Glu His Asp Ala Ile Leu Glu His Phe Ala Gln Asp Pro Thr Glu Ser
            100                 105                 110         
Ile Leu Thr Ile Phe Ile Asp Pro Cys Phe Gly Leu Lys Leu Glu Leu
        115                 120                 125             
Gly Met Pro Val Gln Thr Gln Asn Gln Leu Val Tyr Phe Ile Arg Gln
    130                 135                 140                 
Ala Pro Val Pro Ile Thr Trp Glu Asn Phe Glu Ala Thr Val Gln Phe
145                 150                 155                 160 
Gly Thr Val Arg Gly Pro Tyr Ile Pro Ala Leu Leu Arg Leu Leu Gly
                165                 170                 175     
Gly Val Phe Ala Pro Gln Ile Phe Ala Asn Thr Gly Trp Pro Glu Ser
            180                 185                 190         
Ile Arg Asn His Phe Ala Ser His Leu His Lys Phe Leu Ala Cys Leu
        195                 200                 205             
Thr Asp Thr Arg Tyr Lys Leu Glu Gly His Thr Val Leu Tyr Ile Pro
    210                 215                 220                 
Ala Glu Ala Met Asn Met Lys Pro Glu Met Val Ile Lys Asp Lys Glu
225                 230                 235                 240 
Leu Val Gln Arg Leu Glu Thr Ser Met Ile His Trp Thr Arg Gln Ile
                245                 250                 255     
Lys Glu Met Leu Ser Ala Gln Glu Thr Val Glu Thr Gly Glu Asn Leu
            260                 265                 270         
Gly Pro Leu Glu Glu Ile Glu Phe Trp Arg Asn Arg Cys Met Asp Leu
        275                 280                 285             
Ser Gly Ile Ser Lys Gln Leu Val Lys Lys Gly Val Lys His Val Glu
    290                 295                 300                 
Ser Ile Leu His Leu Ala Lys Ser Ser Tyr Leu Ala Pro Phe Met Lys
305                 310                 315                 320 
Leu Ala Gln Gln Ile Gln Asp Gly Ser Arg Gln Ala Gln Ser Asn Leu
                325                 330                 335     
Thr Phe Leu Ser Ile Leu Lys Glu Pro Tyr Gln Glu Leu Ala Phe Met
            340                 345                 350         
Lys Pro Lys Asp Ile Ser Ser Lys Leu Pro Lys Leu Ile Ser Leu Ile
        355                 360                 365             
Arg Ile Ile Trp Val Asn Ser Pro His Tyr Asn Thr Arg Glu Arg Leu
    370                 375                 380                 
Thr Ser Leu Phe Arg Lys Val Cys Asp Cys Gln Tyr His Phe Ala Arg
385                 390                 395                 400 
Trp Glu Asp Gly Lys Gln Gly Pro Leu Pro Cys Phe Phe Gly Ala Gln
                405                 410                 415     
Gly Pro Gln Ile Thr Arg Asn Leu Leu Glu Ile Glu Asp Ile Phe His
            420                 425                 430         
Lys Asn Leu His Thr Leu Arg Ala Val Arg Gly Gly Ile Leu Asp Val
        435                 440                 445             
Lys Asn Thr Cys Trp His Glu Asp Tyr Asn Lys Phe Arg Ala Gly Ile
    450                 455                 460                 
Lys Asp Leu Glu Val Met Thr Gln Asn Leu Ile Thr Ser Ala Phe Glu
465                 470                 475                 480 
Leu Val Arg Asp Val Pro His Gly Val Leu Leu Leu Asp Thr Phe His
                485                 490                 495     
Arg Leu Ala Ser Arg Glu Ala Ile Lys Arg Thr Tyr Asp Lys Lys Ala
            500                 505                 510         
Val Asp Leu Tyr Met Leu Phe Asn Ser Glu Leu Ala Leu Val Asn Arg
        515                 520                 525             
Glu Arg Asn Lys Lys Trp Pro Asp Leu Glu Pro Tyr Val Ala Gln Tyr
    530                 535                 540                 
Ser Gly Lys Ala Arg Trp Val His Ile Leu Arg Arg Arg Ile Asp Arg
545                 550                 555                 560 
Val Met Thr Cys Leu Ala Gly Ala His Phe Leu Pro Arg Ile Gly Thr
                565                 570                 575     
Gly Lys Glu Ser Val His Thr Tyr Gln Gln Met Val Gln Ala Ile Asp
            580                 585                 590         
Glu Leu Val Arg Lys Thr Phe Gln Glu Trp Thr Ser Ser Leu Asp Lys
        595                 600                 605             
Asp Cys Ile Arg Arg Leu Asp Thr Pro Leu Leu Arg Ile Ser Gln Glu
    610                 615                 620                 
Lys Ala Gly Met Leu Asp Val Asn Phe Asp Lys Tyr Arg Ser His Leu
625                 630                 635                 640 
Ala Pro Phe Pro Tyr Thr Pro Leu Leu Gln Leu Ser Gln Glu Phe His
                645                 650                 655     
Ser His Leu Leu Thr Pro Leu Phe Ile Ile Leu Ser Leu Ser His Thr
            660                 665                 670         
Ile Cys Leu Leu Ser Ser Phe Tyr Phe Phe Phe Ser Ser Phe Ile Phe
        675                 680                 685             
Val Ser Pro His Leu Pro Pro Cys Tyr Gln His Phe Asn Phe Thr Thr
    690                 695                 700                 
Tyr Leu Lys Thr Gln Gln Asn Lys Thr Met Ile Gly Gln Ala Arg Trp
705                 710                 715                 720 
Leu Thr Pro Val Ile Pro Ala Leu Trp Glu Ala Glu Val Gly Ala Ser
                725                 730                 735     
Leu Glu Pro Arg Ser Leu Arg Thr Ala Trp Ala Thr Trp Gln Asn Pro
            740                 745                 750         
Val Ser Ala Lys Asn Thr Lys Ile Ser Trp Ala Trp Trp His Lys Pro
        755                 760                 765             
Val Val Ser Ala Thr Trp Glu Gly Glu Val Gly Gly Ser Pro Glu Pro
    770                 775                 780                 
Gly Arg Gln Arg Leu Gln
785                 790 


<210> 2179
<211> 206
<212> PRT
<213> Homo sapiens

<400> 2179
Met Ala Ala Gly Glu Ser Met Ala Gln Arg Met Val Trp Val Asp Leu
 1               5                  10                  15      
Glu Met Thr Gly Leu Asp Ile Glu Lys Asp Gln Ile Ile Glu Met Ala
            20                  25                  30          
Cys Leu Ile Thr Asp Ser Asp Leu Asn Ile Leu Ala Glu Gly Pro Asn
        35                  40                  45              
Leu Ile Ile Lys Gln Pro Asp Glu Leu Leu Asp Ser Met Ser Asp Trp
    50                  55                  60                  
Cys Lys Glu His His Gly Lys Gln Ser Gly Leu Thr Lys Ala Val Lys
65                  70                  75                  80  
Glu Ser Thr Ile Thr Leu Gln Gln Ala Glu Tyr Glu Phe Leu Ser Phe
                85                  90                  95      
Val Arg Gln Gln Thr Pro Pro Gly Leu Cys Pro Leu Ala Gly Asn Ser
            100                 105                 110         
Val His Glu Asp Lys Lys Phe Leu Asp Lys Tyr Met Pro Gln Phe Met
        115                 120                 125             
Lys His Leu His Tyr Arg Ile Ile Asp Val Ser Thr Val Lys Glu Leu
    130                 135                 140                 
Cys Arg Arg Trp Tyr Pro Glu Glu Tyr Glu Phe Ala Pro Lys Lys Ala
145                 150                 155                 160 
Ala Ser His Arg Ala Leu Asp Asp Ile Ser Glu Ser Ile Lys Glu Leu
                165                 170                 175     
Gln Phe Tyr Arg Asn Asn Ile Phe Lys Lys Lys Ile Asp Glu Lys Lys
            180                 185                 190         
Arg Lys Ile Ile Glu Asn Gly Glu Asn Glu Lys Thr Val Ser
        195                 200                 205     


<210> 2180
<211> 1313
<212> PRT
<213> Homo sapiens

<400> 2180
Met Asp Ser Ser Val Ser Pro Ala Ala Thr Thr Ala Cys Val Pro Tyr
 1               5                  10                  15      
Ala Pro Ser Arg Pro Pro Gly Leu Pro Gly Thr Thr Thr Ser Ser Ser
            20                  25                  30          
Ser Ser Ser Ser Ser Asn Thr Gly Leu Arg Gly Val Glu Pro Asn Pro
        35                  40                  45              
Gly Ile Pro Gly Ala Asp His Tyr Gln Thr Pro Ala Leu Glu Val Ser
    50                  55                  60                  
His His Gly Arg Leu Gly Pro Ser Ala His Ser Ser Arg Lys Pro Phe
65                  70                  75                  80  
Leu Gly Ala Pro Ala Ala Thr Pro His Leu Ser Leu Pro Pro Gly Pro
                85                  90                  95      
Ser Ser Pro Pro Pro Pro Pro Cys Pro Arg Leu Leu Arg Pro Pro Pro
            100                 105                 110         
Pro Pro Ala Trp Leu Lys Gly Pro Ala Cys Arg Ala Ala Arg Glu Asp
        115                 120                 125             
Gly Glu Ile Leu Glu Glu Leu Phe Phe Gly Thr Glu Gly Pro Pro Arg
    130                 135                 140                 
Pro Ala Pro Pro Pro Leu Pro His Arg Glu Gly Phe Leu Gly Pro Pro
145                 150                 155                 160 
Ala Ser Arg Phe Ser Val Gly Thr Gln Asp Ser His Thr Pro Pro Thr
                165                 170                 175     
Pro Pro Thr Pro Thr Thr Ser Ser Ser Asn Ser Asn Ser Gly Ser His
            180                 185                 190         
Ser Ser Ser Pro Ala Gly Pro Val Ser Phe Pro Pro Pro Pro Tyr Leu
        195                 200                 205             
Ala Arg Ser Ile Asp Pro Leu Pro Arg Pro Pro Ser Pro Ala Gln Asn
    210                 215                 220                 
Pro Gln Asp Pro Pro Leu Val Pro Leu Thr Leu Ala Leu Pro Pro Ala
225                 230                 235                 240 
Pro Pro Ser Ser Cys His Gln Asn Thr Ser Gly Ser Phe Arg Arg Pro
                245                 250                 255     
Glu Ser Pro Arg Pro Arg Val Ser Phe Pro Lys Thr Pro Glu Val Gly
            260                 265                 270         
Pro Gly Pro Pro Pro Gly Pro Leu Ser Lys Ala Pro Gln Pro Val Pro
        275                 280                 285             
Pro Gly Val Gly Glu Leu Pro Ala Arg Gly Pro Arg Leu Phe Asp Phe
    290                 295                 300                 
Pro Pro Thr Pro Leu Glu Asp Gln Phe Glu Glu Pro Ala Glu Phe Lys
305                 310                 315                 320 
Ile Leu Pro Asp Gly Leu Ala Asn Ile Met Lys Met Leu Asp Glu Ser
                325                 330                 335     
Ile Arg Lys Glu Glu Glu Gln Gln Gln His Glu Ala Gly Val Ala Pro
            340                 345                 350         
Gln Pro Pro Leu Lys Glu Pro Phe Ala Ser Leu Gln Ser Pro Phe Pro
        355                 360                 365             
Thr Asp Thr Ala Pro Thr Thr Thr Ala Pro Ala Val Ala Val Thr Thr
    370                 375                 380                 
Thr Thr Thr Thr Thr Thr Thr Thr Thr Ala Thr Gln Glu Glu Glu Lys
385                 390                 395                 400 
Lys Pro Pro Pro Ala Leu Pro Pro Pro Pro Pro Leu Ala Lys Phe Pro
                405                 410                 415     
Pro Pro Ser Gln Pro Gln Pro Pro Pro Pro Pro Pro Pro Ser Pro Ala
            420                 425                 430         
Ser Leu Leu Lys Ser Leu Ala Ser Val Leu Glu Gly Gln Lys Tyr Cys
        435                 440                 445             
Tyr Arg Gly Thr Gly Ala Ala Val Ser Thr Arg Pro Gly Pro Leu Pro
    450                 455                 460                 
Thr Thr Gln Tyr Ser Pro Gly Pro Pro Ser Gly Ala Thr Ala Leu Pro
465                 470                 475                 480 
Pro Thr Ser Ala Ala Pro Ser Ala Gln Gly Ser Pro Gln Pro Ser Ala
                485                 490                 495     
Ser Ser Ser Ser Gln Phe Ser Thr Ser Gly Gly Pro Trp Ala Arg Glu
            500                 505                 510         
Arg Arg Ala Gly Glu Glu Pro Val Pro Gly Pro Met Thr Pro Thr Gln
        515                 520                 525             
Pro Pro Pro Pro Leu Ser Leu Pro Pro Ala Arg Ser Glu Ser Glu Val
    530                 535                 540                 
Leu Glu Glu Ile Ser Arg Ala Cys Glu Thr Leu Val Glu Arg Val Gly
545                 550                 555                 560 
Arg Ser Ala Thr Asp Pro Ala Asp Pro Val Asp Thr Ala Glu Pro Ala
                565                 570                 575     
Asp Ser Gly Thr Glu Arg Leu Leu Pro Pro Ala Gln Ala Lys Glu Glu
            580                 585                 590         
Ala Gly Gly Val Ala Ala Val Ser Gly Ser Cys Lys Arg Arg Gln Lys
        595                 600                 605             
Glu His Gln Lys Glu His Arg Arg His Arg Arg Ala Cys Lys Asp Ser
    610                 615                 620                 
Val Gly Arg Arg Pro Arg Glu Gly Arg Ala Lys Ala Lys Ala Lys Val
625                 630                 635                 640 
Pro Lys Glu Lys Ser Arg Arg Val Leu Gly Asn Leu Asp Leu Gln Ser
                645                 650                 655     
Glu Glu Ile Gln Gly Arg Glu Lys Ser Arg Pro Asp Leu Gly Gly Ala
            660                 665                 670         
Ser Lys Ala Lys Pro Pro Thr Ala Pro Ala Pro Pro Ser Ala Pro Ala
        675                 680                 685             
Pro Ser Ala Gln Pro Thr Pro Pro Ser Ala Ser Val Pro Gly Lys Lys
    690                 695                 700                 
Ala Arg Glu Glu Ala Pro Gly Pro Pro Gly Val Ser Arg Ala Asp Met
705                 710                 715                 720 
Leu Lys Leu Arg Ser Leu Ser Glu Gly Pro Pro Lys Glu Leu Lys Ile
                725                 730                 735     
Arg Leu Ile Lys Val Glu Ser Gly Asp Lys Glu Thr Phe Ile Ala Ser
            740                 745                 750         
Glu Val Glu Glu Arg Arg Leu Arg Met Ala Asp Leu Thr Ile Ser His
        755                 760                 765             
Cys Ala Ala Asp Val Val Arg Ala Ser Arg Asn Ala Lys Val Lys Gly
    770                 775                 780                 
Lys Phe Arg Glu Ser Tyr Leu Ser Pro Ala Gln Ser Val Lys Pro Lys
785                 790                 795                 800 
Ile Asn Thr Glu Glu Lys Leu Pro Arg Glu Lys Leu Asn Pro Pro Thr
                805                 810                 815     
Pro Ser Ile Tyr Leu Glu Ser Lys Arg Asp Ala Phe Ser Pro Val Leu
            820                 825                 830         
Leu Gln Phe Cys Thr Asp Pro Arg Asn Pro Ile Thr Val Ile Arg Gly
        835                 840                 845             
Leu Ala Gly Ser Leu Arg Leu Asn Leu Gly Leu Phe Ser Thr Lys Thr
    850                 855                 860                 
Leu Val Glu Ala Ser Gly Glu His Thr Val Glu Val Arg Thr Gln Val
865                 870                 875                 880 
Gln Gln Pro Ser Asp Glu Asn Trp Asp Leu Thr Gly Thr Arg Gln Ile
                885                 890                 895     
Trp Pro Cys Glu Ser Ser Arg Ser His Thr Thr Ile Ala Lys Tyr Ala
            900                 905                 910         
Gln Tyr Gln Ala Ser Ser Phe Gln Glu Ser Leu Gln Glu Glu Lys Glu
        915                 920                 925             
Ser Glu Asp Glu Glu Ser Glu Glu Pro Asp Ser Thr Thr Gly Thr Pro
    930                 935                 940                 
Pro Ser Ser Ala Pro Asp Pro Lys Asn His His Ile Ile Lys Phe Gly
945                 950                 955                 960 
Thr Asn Ile Asp Leu Ser Asp Ala Lys Arg Trp Lys Pro Gln Leu Gln
                965                 970                 975     
Glu Leu Leu Lys Leu Pro Ala Phe Met Arg Val Thr Ser Thr Gly Asn
            980                 985                 990         
Met Leu Ser His Val Gly His Thr Ile Leu Gly Met Asn Thr Val Gln
        995                 1000                1005            
Leu Tyr Met Lys Val Pro Gly Ser Arg Thr Pro Gly His Gln Glu Asn
    1010                1015                1020                
Asn Asn Phe Cys Ser Val Asn Ile Asn Ile Gly Pro Gly Asp Cys Glu
1025                1030                1035                1040
Trp Phe Ala Val His Glu His Tyr Trp Glu Thr Ile Ser Ala Phe Cys
                1045                1050                1055    
Asp Arg His Gly Val Asp Tyr Leu Thr Gly Ser Trp Trp Pro Ile Leu
            1060                1065                1070        
Asp Asp Leu Tyr Ala Ser Asn Ile Pro Val Tyr Arg Phe Val Gln Arg
        1075                1080                1085            
Pro Gly Asp Leu Val Trp Ile Asn Ala Gly Thr Val His Trp Val Gln
    1090                1095                1100                
Ala Thr Gly Trp Cys Asn Asn Ile Ala Trp Asn Val Gly Pro Leu Thr
1105                1110                1115                1120
Ala Tyr Gln Tyr Gln Leu Ala Leu Glu Arg Tyr Glu Trp Asn Glu Val
                1125                1130                1135    
Lys Asn Val Lys Ser Ile Val Pro Met Ile His Val Ser Trp Asn Val
            1140                1145                1150        
Ala Arg Thr Val Lys Ile Ser Asp Pro Asp Leu Phe Lys Met Ile Lys
        1155                1160                1165            
Phe Cys Leu Leu Gln Ser Met Lys His Cys Gln Val Gln Arg Glu Ser
    1170                1175                1180                
Leu Val Arg Ala Gly Lys Lys Ile Ala Tyr Gln Gly Arg Val Lys Asp
1185                1190                1195                1200
Glu Pro Ala Tyr Tyr Cys Asn Glu Cys Asp Val Glu Val Phe Asn Ile
                1205                1210                1215    
Leu Phe Val Thr Ser Glu Asn Gly Ser Arg Asn Thr Tyr Leu Val His
            1220                1225                1230        
Cys Glu Gly Cys Ala Arg Arg Arg Ser Ala Gly Leu Gln Gly Val Val
        1235                1240                1245            
Val Leu Glu Gln Tyr Arg Thr Glu Glu Leu Ala Gln Ala Tyr Asp Ala
    1250                1255                1260                
Phe Thr Leu Val Arg Ala Arg Arg Ala Arg Gly Gln Arg Arg Arg Ala
1265                1270                1275                1280
Leu Gly Gln Ala Ala Gly Thr Gly Phe Gly Ser Pro Ala Ala Pro Phe
                1285                1290                1295    
Pro Glu Pro Pro Pro Ala Phe Ser Pro Gln Ala Pro Ala Ser Thr Ser
            1300                1305                1310        
Arg
    


<210> 2181
<211> 1101
<212> PRT
<213> Homo sapiens

<400> 2181
Met Val Ala Leu Leu Leu Glu Phe Gly Ala Asn Val Asp Ala Ser Ser
 1               5                  10                  15      
Glu Ser Gly Leu Thr Pro Leu Gly Tyr Ala Ala Ala Ala Gly Tyr Leu
            20                  25                  30          
Ser Ile Val Val Leu Leu Cys Lys Lys Arg Ala Lys Val Asp His Leu
        35                  40                  45              
Asp Lys Asn Gly Gln Cys Ala Leu Val His Ala Ala Leu Arg Gly His
    50                  55                  60                  
Leu Glu Val Val Lys Phe Leu Ile Gln Cys Asp Trp Thr Met Ala Gly
65                  70                  75                  80  
Gln Gln Gln Gly Val Phe Lys Lys Ser His Ala Ile Gln Gln Ala Leu
                85                  90                  95      
Ile Ala Ala Ala Ser Met Gly Tyr Thr Glu Ile Val Ser Tyr Leu Leu
            100                 105                 110         
Asp Leu Pro Glu Lys Asp Glu Glu Glu Val Glu Arg Ala Gln Ile Asn
        115                 120                 125             
Ser Phe Asp Ser Leu Trp Gly Glu Thr Ala Leu Thr Ala Ala Ala Gly
    130                 135                 140                 
Arg Gly Lys Leu Glu Val Cys Arg Leu Leu Leu Glu Gln Gly Ala Ala
145                 150                 155                 160 
Val Ala Gln Pro Asn Arg Arg Gly Ala Val Pro Leu Phe Ser Thr Val
                165                 170                 175     
Arg Gln Gly His Trp Gln Ile Val Asp Leu Leu Leu Thr His Gly Ala
            180                 185                 190         
Asp Val Asn Met Ala Asp Lys Gln Gly Arg Thr Pro Leu Met Met Ala
        195                 200                 205             
Ala Ser Glu Gly His Leu Gly Thr Val Asp Phe Leu Leu Ala Gln Gly
    210                 215                 220                 
Ala Ser Ile Ala Leu Met Asp Lys Glu Gly Leu Thr Ala Leu Ser Trp
225                 230                 235                 240 
Ala Cys Leu Lys Gly His Leu Ser Val Val Arg Ser Leu Val Asp Asn
                245                 250                 255     
Gly Ala Ala Thr Asp His Ala Asp Lys Asn Gly Arg Thr Pro Leu Asp
            260                 265                 270         
Leu Ala Ala Phe Tyr Gly Asp Ala Glu Val Val Gln Phe Leu Val Asp
        275                 280                 285             
His Gly Ala Met Ile Glu His Val Asp Tyr Ser Gly Met Arg Pro Leu
    290                 295                 300                 
Asp Arg Ala Val Gly Cys Arg Asn Thr Ser Val Val Val Thr Leu Leu
305                 310                 315                 320 
Lys Lys Gly Ala Lys Ile Gly Cys Gln Thr Leu Pro Ser Arg Pro Arg
                325                 330                 335     
Gly Pro Ala Thr Trp Ala Met Ala Thr Ser Lys Pro Asp Ile Met Ile
            340                 345                 350         
Ile Leu Leu Ser Lys Leu Met Glu Glu Gly Asp Met Phe Tyr Lys Lys
        355                 360                 365             
Gly Lys Val Lys Glu Ala Ala Gln Arg Tyr Gln Tyr Ala Leu Lys Lys
    370                 375                 380                 
Phe Pro Arg Glu Gly Phe Gly Glu Asp Leu Lys Thr Phe Arg Glu Leu
385                 390                 395                 400 
Lys Val Ser Leu Leu Leu Asn Leu Ser Arg Cys Arg Arg Lys Met Asn
                405                 410                 415     
Asp Phe Gly Met Ala Glu Glu Phe Ala Thr Lys Ala Leu Glu Leu Lys
            420                 425                 430         
Pro Lys Ser Tyr Glu Ala Tyr Tyr Ala Arg Ala Arg Ala Lys Arg Ser
        435                 440                 445             
Ser Arg Gln Phe Ala Ala Ala Leu Glu Asp Leu Asn Glu Ala Ile Lys
    450                 455                 460                 
Leu Cys Pro Asn Asn Arg Glu Ile Gln Arg Leu Leu Leu Arg Val Glu
465                 470                 475                 480 
Glu Glu Cys Arg Gln Met Gln Gln Pro Gln Gln Pro Pro Pro Pro Pro
                485                 490                 495     
Gln Pro Gln Gln Gln Leu Pro Glu Glu Ala Glu Pro Glu Pro Gln His
            500                 505                 510         
Glu Asp Ile Tyr Ser Val Gln Asp Ile Phe Glu Glu Glu Tyr Leu Glu
        515                 520                 525             
Gln Asp Val Glu Asn Val Ser Ile Gly Leu Gln Thr Glu Ala Arg Pro
    530                 535                 540                 
Ser Gln Gly Leu Pro Val Ile Gln Ser Pro Pro Ser Ser Pro Pro His
545                 550                 555                 560 
Arg Asp Ser Ala Tyr Ile Ser Ser Ser Pro Leu Gly Ser His Gln Val
                565                 570                 575     
Phe Asp Phe Arg Ser Ser Ser Ser Val Gly Ser Pro Thr Arg Gln Thr
            580                 585                 590         
Tyr Gln Ser Thr Ser Pro Ala Leu Ser Pro Thr His Gln Asn Ser His
        595                 600                 605             
Tyr Arg Pro Ser Pro Pro His Thr Ser Pro Ala His Gln Gly Gly Ser
    610                 615                 620                 
Tyr Arg Phe Ser Pro Pro Pro Val Gly Gly Gln Gly Lys Glu Tyr Pro
625                 630                 635                 640 
Ser Pro Pro Pro Ser Pro Leu Arg Arg Gly Pro Gln Tyr Arg Ala Ser
                645                 650                 655     
Pro Pro Ala Glu Ser Met Ser Val Tyr Arg Ser Gln Ser Gly Ser Pro
            660                 665                 670         
Val Arg Tyr Gln Gln Glu Thr Ser Val Ser Gln Leu Pro Gly Arg Pro
        675                 680                 685             
Lys Ser Pro Leu Ser Lys Met Ala Gln Arg Pro Tyr Gln Met Pro Gln
    690                 695                 700                 
Leu Pro Val Ala Val Pro Gln Gln Gly Leu Arg Leu Gln Pro Ala Lys
705                 710                 715                 720 
Ala Gln Ile Val Arg Ser Asn Gln Pro Ser Pro Ala Val His Ser Ser
                725                 730                 735     
Thr Val Ile Pro Thr Gly Ala Tyr Gly Gln Val Ala His Ser Met Ala
            740                 745                 750         
Ser Lys Tyr Gln Ser Ser Gln Gly Asp Ile Gly Val Ser Gln Ser Arg
        755                 760                 765             
Leu Val Tyr Gln Gly Ser Ile Gly Gly Ile Val Gly Asp Gly Arg Pro
    770                 775                 780                 
Val Gln His Val Gln Ala Ser Leu Ser Ala Gly Ala Ile Cys Gln His
785                 790                 795                 800 
Gly Gly Leu Thr Lys Glu Asp Leu Pro Gln Arg Pro Ser Ser Ala Tyr
                805                 810                 815     
Arg Gly Gly Val Arg Tyr Ser Gln Thr Pro Gln Ile Gly Arg Ser Gln
            820                 825                 830         
Ser Ala Ser Tyr Tyr Pro Val Cys His Ser Lys Leu Asp Leu Glu Arg
        835                 840                 845             
Ser Ser Ser Gln Leu Gly Ser Pro Asp Val Ser His Leu Ile Arg Arg
    850                 855                 860                 
Pro Ile Ser Val Asn Pro Asn Glu Ile Lys Pro His Pro Pro Thr Pro
865                 870                 875                 880 
Arg Pro Leu Leu His Ser Gln Ser Val Gly Leu Arg Phe Ser Pro Ser
                885                 890                 895     
Ser Asn Ser Ile Ser Ser Thr Ser Asn Leu Thr Pro Thr Phe Arg Pro
            900                 905                 910         
Ser Ser Ser Ile Gln Gln Met Glu Ile Pro Leu Lys Pro Ala Tyr Glu
        915                 920                 925             
Arg Ser Cys Asp Glu Leu Ser Pro Val Ser Pro Thr Gln Gly Gly Tyr
    930                 935                 940                 
Pro Ser Glu Pro Thr Arg Ser Arg Thr Thr Pro Phe Met Gly Ile Ile
945                 950                 955                 960 
Asp Lys Thr Ala Arg Thr Gln Gln Tyr Pro His Leu His Gln Gln Asn
                965                 970                 975     
Arg Thr Trp Ala Val Ser Ser Val Asp Thr Val Leu Ser Pro Thr Ser
            980                 985                 990         
Pro Gly Asn Leu Pro Gln Pro Glu Ser Phe Ser Pro Pro Ser Ser Ile
        995                 1000                1005            
Ser Asn Ile Ala Phe Tyr Asn Lys Thr Asn Asn Ala Gln Asn Gly His
    1010                1015                1020                
Leu Leu Glu Asp Asp Tyr Tyr Ser Pro His Gly Met Leu Ala Asn Gly
1025                1030                1035                1040
Ser Arg Gly Asp Leu Leu Glu Arg Val Ser Gln Ala Ser Ser Tyr Pro
                1045                1050                1055    
Asp Val Lys Val Ala Arg Thr Leu Pro Val Ala Gln Ala Tyr Gln Asp
            1060                1065                1070        
Asn Leu Tyr Arg Gln Leu Ser Arg Asp Ser Arg Gln Gly Gln Thr Ser
        1075                1080                1085            
Pro Ile Lys Pro Lys Arg Pro Phe Val Glu Ser Asn Val
    1090                1095                1100    


<210> 2182
<211> 818
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 10, 11, 13, 80, 814
<223> Xaa = Any Amino Acid

<400> 2182
Met Asn Arg Ser Gly Arg Thr Ser Arg Xaa Xaa Ala Xaa Cys Ala Gly
 1               5                  10                  15      
Ser Ser Glu Leu Cys Ala Pro Trp Ala Leu Pro Thr Leu Pro Leu Ala
            20                  25                  30          
Lys Arg Gln Gln Tyr Asn Ala Leu Leu Ser Asn Met Ser Arg Ile Tyr
        35                  40                  45              
Ser Thr Ala Lys Val Cys Leu Pro Asn Lys Thr Ala Thr Cys Trp Ser
    50                  55                  60                  
Leu Asp Pro Asp Leu Thr Asn Ile Leu Ala Ser Ser Arg Thr Thr Xaa
65                  70                  75                  80  
Met Leu Leu Phe Ala Trp Glu Gly Trp His Asn Ala Ala Gly Ile Pro
                85                  90                  95      
Leu Lys Pro Leu Tyr Glu Asp Phe Thr Ala Leu Ser Asn Glu Ala Tyr
            100                 105                 110         
Lys Gln Asp Gly Phe Thr Asp Thr Gly Ala Tyr Trp Arg Ser Trp Tyr
        115                 120                 125             
Asn Ser Pro Thr Phe Glu Asp Asp Leu Glu His Leu Tyr Gln Gln Leu
    130                 135                 140                 
Glu Pro Leu Tyr Leu Asn Leu His Ala Phe Val Arg Arg Ala Leu His
145                 150                 155                 160 
Arg Arg Tyr Gly Asp Arg Tyr Ile Asn Leu Arg Gly Pro Ile Pro Ala
                165                 170                 175     
His Leu Leu Gly Asp Met Trp Ala Gln Ser Trp Glu Asn Ile Tyr Asp
            180                 185                 190         
Met Val Val Pro Phe Pro Asp Lys Pro Asn Leu Asp Val Thr Ser Thr
        195                 200                 205             
Met Leu Gln Gln Gly Trp Asn Ala Thr His Met Phe Arg Val Ala Glu
    210                 215                 220                 
Glu Phe Phe Thr Ser Leu Glu Leu Ser Pro Met Pro Pro Glu Phe Trp
225                 230                 235                 240 
Glu Gly Ser Met Leu Glu Lys Pro Ala Asp Gly Arg Glu Val Val Cys
                245                 250                 255     
His Ala Ser Ala Trp Asp Phe Tyr Asn Arg Lys Asp Phe Arg Ile Lys
            260                 265                 270         
Gln Cys Thr Arg Val Thr Met Asp Gln Leu Ser Thr Val His His Glu
        275                 280                 285             
Met Gly His Ile Gln Tyr Tyr Leu Gln Tyr Lys Asp Leu Pro Val Ser
    290                 295                 300                 
Leu Arg Arg Gly Ala Asn Pro Gly Phe His Glu Ala Ile Gly Asp Val
305                 310                 315                 320 
Leu Ala Leu Ser Val Ser Thr Pro Glu His Leu His Lys Ile Gly Leu
                325                 330                 335     
Leu Asp Arg Val Thr Asn Asp Thr Glu Ser Asp Ile Asn Tyr Leu Leu
            340                 345                 350         
Lys Met Ala Leu Glu Lys Ile Ala Phe Leu Pro Phe Gly Tyr Leu Val
        355                 360                 365             
Asp Gln Trp Arg Trp Gly Val Phe Ser Gly Arg Thr Pro Pro Ser Arg
    370                 375                 380                 
Tyr Asn Phe Asp Trp Trp Tyr Leu Arg Thr Lys Tyr Gln Gly Ile Cys
385                 390                 395                 400 
Pro Pro Val Thr Arg Asn Glu Thr His Phe Asp Ala Gly Ala Lys Phe
                405                 410                 415     
His Val Pro Asn Val Thr Pro Tyr Ile Arg Tyr Phe Val Ser Phe Val
            420                 425                 430         
Leu Gln Phe Gln Phe His Glu Ala Leu Cys Lys Glu Ala Gly Tyr Glu
        435                 440                 445             
Gly Pro Leu His Gln Cys Asp Ile Tyr Arg Ser Thr Lys Ala Gly Ala
    450                 455                 460                 
Lys Leu Arg Lys Val Leu Gln Ala Gly Ser Ser Arg Pro Trp Gln Glu
465                 470                 475                 480 
Val Leu Lys Asp Met Val Gly Leu Asp Ala Leu Asp Ala Gln Pro Leu
                485                 490                 495     
Leu Lys Tyr Phe Gln Pro Val Thr Gln Trp Leu Gln Glu Gln Asn Gln
            500                 505                 510         
Gln Asn Gly Glu Val Leu Gly Trp Pro Glu Tyr Gln Trp His Pro Pro
        515                 520                 525             
Leu Pro Asp Asn Tyr Pro Glu Gly Ile Asp Leu Val Thr Asp Glu Ala
    530                 535                 540                 
Glu Ala Ser Lys Phe Val Glu Glu Tyr Asp Arg Thr Ser Gln Val Val
545                 550                 555                 560 
Trp Asn Glu Tyr Ala Glu Ala Asn Trp Asn Tyr Asn Thr Asn Ile Thr
                565                 570                 575     
Thr Glu Thr Ser Lys Ile Leu Leu Gln Lys Asn Met Gln Ile Ala Asn
            580                 585                 590         
His Thr Leu Lys Tyr Gly Thr Gln Ala Arg Lys Phe Asp Val Asn Gln
        595                 600                 605             
Leu Gln Asn Thr Thr Ile Lys Arg Ile Ile Lys Lys Val Gln Asp Leu
    610                 615                 620                 
Glu Arg Ala Ala Leu Pro Ala Gln Glu Leu Glu Glu Tyr Asn Lys Ile
625                 630                 635                 640 
Leu Leu Asp Met Glu Thr Thr Tyr Ser Val Ala Thr Val Cys His Pro
                645                 650                 655     
Asn Gly Ser Cys Leu Gln Leu Glu Pro Asp Leu Thr Asn Val Met Ala
            660                 665                 670         
Thr Ser Arg Lys Tyr Glu Asp Leu Leu Trp Ala Trp Glu Gly Trp Arg
        675                 680                 685             
Asp Lys Ala Gly Arg Ala Ile Leu Gln Phe Tyr Pro Lys Tyr Val Glu
    690                 695                 700                 
Leu Ile Asn Gln Ala Ala Arg Leu Asn Gly Tyr Val Asp Ala Gly Asp
705                 710                 715                 720 
Ser Trp Arg Ser Met Tyr Glu Thr Pro Ser Leu Glu Gln Asp Leu Glu
                725                 730                 735     
Arg Leu Phe Gln Glu Leu Gln Pro Leu Tyr Leu Asn Leu His Ala Tyr
            740                 745                 750         
Val Arg Arg Ala Leu His Arg His Tyr Gly Ala Gln His Ile Asn Leu
        755                 760                 765             
Glu Gly Pro Ile Pro Ala His Leu Leu Gly Asn Met Trp Ala Gln Thr
    770                 775                 780                 
Trp Ser Asn Ile Tyr Asp Leu Val Val Pro Phe Pro Ser Ala Pro Ser
785                 790                 795                 800 
Met Asp Thr Thr Glu Ala Met Leu Lys Gln Gly Trp Thr Xaa Gln Glu
                805                 810                 815     
Asp Val
        


<210> 2183
<211> 297
<212> PRT
<213> Homo sapiens

<400> 2183
Met Ser Ala Trp Ala Ala Ala Ser Leu Ser Arg Ala Ala Ala Arg Cys
 1               5                  10                  15      
Leu Leu Ala Arg Gly Pro Gly Val Arg Ala Ala Pro Pro Arg Asp Pro
            20                  25                  30          
Arg Pro Ser His Pro Glu Pro Arg Gly Cys Gly Ala Ala Pro Gly Arg
        35                  40                  45              
Thr Leu His Phe Thr Ala Ala Val Pro Ala Gly His Asn Lys Trp Ser
    50                  55                  60                  
Lys Val Arg His Ile Lys Gly Pro Lys Asp Val Glu Arg Ser Arg Ile
65                  70                  75                  80  
Phe Ser Lys Leu Cys Leu Asn Ile Arg Leu Ala Val Lys Glu Gly Gly
                85                  90                  95      
Pro Asn Pro Glu His Asn Ser Asn Leu Ala Asn Ile Leu Glu Val Cys
            100                 105                 110         
Arg Ser Lys His Met Pro Lys Ser Thr Ile Glu Thr Ala Leu Lys Met
        115                 120                 125             
Glu Lys Ser Lys Asp Thr Tyr Leu Leu Tyr Glu Gly Arg Gly Pro Gly
    130                 135                 140                 
Gly Ser Ser Leu Leu Ile Glu Ala Leu Ser Asn Ser Ser His Lys Cys
145                 150                 155                 160 
Gln Ala Asp Ile Arg His Ile Leu Asn Lys Asn Gly Gly Val Met Ala
                165                 170                 175     
Val Gly Ala Arg His Ser Phe Asp Lys Lys Gly Val Ile Val Val Glu
            180                 185                 190         
Val Glu Asp Arg Glu Lys Lys Ala Val Asn Leu Glu Arg Ala Leu Glu
        195                 200                 205             
Met Ala Ile Glu Ala Gly Ala Glu Asp Val Lys Glu Thr Glu Asp Glu
    210                 215                 220                 
Glu Glu Arg Asn Val Phe Lys Phe Ile Cys Asp Ala Ser Ser Leu His
225                 230                 235                 240 
Gln Val Arg Lys Lys Leu Asp Ser Leu Gly Leu Cys Ser Val Ser Cys
                245                 250                 255     
Ala Leu Glu Phe Ile Pro Asn Ser Lys Val Gln Leu Ala Glu Pro Asp
            260                 265                 270         
Leu Glu Gln Ala Ala His Leu Ile Gln Ala Leu Ser Asn His Glu Asp
        275                 280                 285             
Val Ile His Val Tyr Asp Asn Ile Glu
    290                 295         


<210> 2184
<211> 345
<212> PRT
<213> Homo sapiens

<400> 2184
Met Ile Ser Pro Val Leu Ile Leu Phe Ser Ser Phe Leu Cys His Val
 1               5                  10                  15      
Ala Ile Ala Gly Arg Thr Cys Pro Lys Pro Asp Asp Leu Pro Phe Ser
            20                  25                  30          
Thr Val Val Pro Leu Lys Thr Phe Tyr Glu Pro Gly Glu Glu Ile Thr
        35                  40                  45              
Tyr Ser Cys Lys Pro Gly Tyr Val Ser Arg Gly Gly Met Arg Lys Phe
    50                  55                  60                  
Ile Cys Pro Leu Thr Gly Leu Trp Pro Ile Asn Thr Leu Lys Cys Thr
65                  70                  75                  80  
Pro Arg Val Cys Pro Phe Ala Gly Ile Leu Glu Asn Gly Ala Val Arg
                85                  90                  95      
Tyr Thr Thr Phe Glu Tyr Pro Asn Thr Ile Ser Phe Ser Cys Asn Thr
            100                 105                 110         
Gly Phe Tyr Leu Asn Gly Ala Asp Ser Ala Lys Cys Thr Glu Glu Gly
        115                 120                 125             
Lys Trp Ser Pro Glu Leu Pro Val Cys Ala Pro Ile Ile Cys Pro Pro
    130                 135                 140                 
Pro Ser Ile Pro Thr Phe Ala Thr Leu Arg Val Tyr Lys Pro Ser Ala
145                 150                 155                 160 
Gly Asn Asn Ser Leu Tyr Arg Asp Thr Ala Val Phe Glu Cys Leu Pro
                165                 170                 175     
Gln His Ala Met Phe Gly Asn Asp Thr Ile Thr Cys Thr Thr His Gly
            180                 185                 190         
Asn Trp Thr Lys Leu Pro Glu Cys Arg Glu Val Lys Cys Pro Phe Pro
        195                 200                 205             
Ser Arg Pro Asp Asn Gly Phe Val Asn Tyr Pro Ala Lys Pro Thr Leu
    210                 215                 220                 
Tyr Tyr Lys Asp Lys Ala Thr Phe Gly Cys His Asp Gly Tyr Ser Leu
225                 230                 235                 240 
Asp Gly Pro Glu Glu Ile Glu Cys Thr Lys Leu Gly Asn Trp Ser Ala
                245                 250                 255     
Met Pro Ser Cys Lys Ala Ser Cys Lys Val Pro Val Lys Lys Ala Thr
            260                 265                 270         
Val Val Tyr Gln Gly Glu Arg Val Lys Ile Gln Glu Lys Phe Lys Asn
        275                 280                 285             
Gly Met Leu His Gly Asp Lys Val Ser Phe Phe Cys Lys Asn Lys Glu
    290                 295                 300                 
Lys Lys Cys Ser Tyr Thr Glu Asp Ala Gln Cys Ile Asp Gly Thr Ile
305                 310                 315                 320 
Glu Val Pro Lys Cys Phe Lys Glu His Ser Ser Leu Ala Phe Trp Lys
                325                 330                 335     
Thr Asp Ala Ser Asp Val Lys Pro Cys
            340                 345 


<210> 2185
<211> 504
<212> PRT
<213> Homo sapiens

<400> 2185
Met Glu Pro Ala Gly Pro Ala Pro Gly Arg Leu Gly Pro Leu Leu Cys
 1               5                  10                  15      
Leu Leu Leu Ala Ala Ser Cys Ala Trp Ser Gly Val Ala Gly Glu Glu
            20                  25                  30          
Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala Ala Gly
        35                  40                  45              
Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro Val Gly
    50                  55                  60                  
Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu Ile Tyr
65                  70                  75                  80  
Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser Asp Leu
                85                  90                  95      
Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn Ile Thr
            100                 105                 110         
Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys Gly Ser
        115                 120                 125             
Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val
    130                 135                 140                 
Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala Arg Ala
145                 150                 155                 160 
Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly Phe Ser
                165                 170                 175     
Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu Leu Ser
            180                 185                 190         
Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser Tyr Ser
        195                 200                 205             
Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val His Ser
    210                 215                 220                 
Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp Pro Leu
225                 230                 235                 240 
Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro Thr Leu
                245                 250                 255     
Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn Val Thr
            260                 265                 270         
Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr Trp Leu
        275                 280                 285             
Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val Thr Glu
    290                 295                 300                 
Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val Asn Val
305                 310                 315                 320 
Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu His Asp
                325                 330                 335     
Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser Ala His
            340                 345                 350         
Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly Ser Asn
        355                 360                 365             
Glu Arg Asn Ile Tyr Ile Val Val Gly Val Val Cys Thr Leu Leu Val
    370                 375                 380                 
Ala Leu Leu Met Ala Ala Leu Tyr Leu Val Arg Ile Arg Gln Lys Lys
385                 390                 395                 400 
Ala Gln Gly Ser Thr Ser Ser Thr Arg Leu His Glu Pro Glu Lys Asn
                405                 410                 415     
Ala Arg Glu Ile Thr Gln Asp Thr Asn Asp Ile Thr Tyr Ala Asp Leu
            420                 425                 430         
Asn Leu Pro Lys Gly Lys Lys Pro Ala Pro Gln Ala Ala Glu Pro Asn
        435                 440                 445             
Asn His Thr Glu Tyr Ala Ser Ile Gln Thr Ser Pro Gln Pro Ala Ser
    450                 455                 460                 
Glu Asp Thr Leu Thr Tyr Ala Asp Leu Asp Met Val His Leu Asn Arg
465                 470                 475                 480 
Thr Pro Lys Gln Pro Ala Pro Lys Pro Glu Pro Ser Phe Ser Glu Tyr
                485                 490                 495     
Ala Ser Val Gln Val Pro Arg Lys
            500                 


<210> 2186
<211> 385
<212> PRT
<213> Homo sapiens

<400> 2186
Met Ala Ala Leu Ser Gly Val Arg Trp Leu Thr Arg Ala Leu Val Ser
 1               5                  10                  15      
Ala Gly Asn Pro Gly Ala Trp Arg Gly Leu Ser Thr Ser Ala Ala Ala
            20                  25                  30          
His Ala Ala Ser Arg Ser Gln Ala Glu Asp Val Arg Val Glu Gly Ser
        35                  40                  45              
Phe Pro Val Thr Met Leu Pro Gly Asp Gly Val Gly Pro Glu Leu Met
    50                  55                  60                  
His Ala Val Lys Glu Val Phe Lys Ala Ala Ala Val Pro Val Glu Phe
65                  70                  75                  80  
Gln Glu His His Leu Ser Glu Val Gln Asn Met Ala Ser Glu Glu Lys
                85                  90                  95      
Leu Glu Gln Val Leu Ser Ser Met Lys Glu Asn Lys Val Ala Ile Ile
            100                 105                 110         
Gly Lys Ile His Thr Pro Met Glu Tyr Lys Gly Glu Leu Ala Ser Tyr
        115                 120                 125             
Asp Met Arg Leu Arg Arg Lys Leu Asp Leu Phe Ala Asn Val Val His
    130                 135                 140                 
Val Lys Ser Leu Pro Gly Tyr Met Thr Arg His Asn Asn Leu Asp Leu
145                 150                 155                 160 
Val Ile Ile Arg Glu Gln Thr Glu Gly Glu Tyr Ser Ser Leu Glu His
                165                 170                 175     
Glu Ser Ala Arg Gly Val Ile Glu Cys Leu Lys Ile Val Thr Arg Ala
            180                 185                 190         
Lys Ser Gln Arg Ile Ala Lys Phe Ala Phe Asp Tyr Ala Thr Lys Lys
        195                 200                 205             
Gly Arg Gly Lys Val Thr Ala Val His Lys Ala Asn Ile Met Lys Leu
    210                 215                 220                 
Gly Asp Gly Leu Phe Leu Gln Cys Cys Glu Glu Val Ala Glu Leu Tyr
225                 230                 235                 240 
Pro Lys Ile Lys Phe Glu Thr Met Ile Ile Asp Asn Cys Cys Met Gln
                245                 250                 255     
Leu Val Gln Asn Pro Tyr Gln Phe Asp Val Leu Val Met Pro Asn Leu
            260                 265                 270         
Tyr Gly Asn Ile Ile Asp Asn Leu Ala Ala Gly Leu Val Gly Gly Ala
        275                 280                 285             
Gly Val Val Pro Gly Glu Ser Tyr Ser Ala Glu Tyr Ala Val Phe Glu
    290                 295                 300                 
Thr Gly Ala Arg His Pro Phe Ala Gln Ala Val Gly Arg Asn Ile Ala
305                 310                 315                 320 
Asn Pro Thr Ala Met Leu Leu Ser Ala Ser Asn Met Leu Arg His Leu
                325                 330                 335     
Asn Leu Glu Tyr His Ser Ser Met Ile Ala Asp Ala Val Lys Lys Val
            340                 345                 350         
Ile Lys Val Gly Lys Val Arg Thr Arg Asp Met Gly Gly Tyr Ser Thr
        355                 360                 365             
Thr Thr Asp Phe Ile Lys Ser Val Ile Gly His Leu Gln Thr Lys Gly
    370                 375                 380                 
Ser
385 


<210> 2187
<211> 597
<212> PRT
<213> Homo sapiens

<400> 2187
Met Ala Leu Asn Ser Pro Gln Pro Gly Pro Val Glu Ser Glu Leu Gly
 1               5                  10                  15      
Lys Gln Leu Leu Lys Thr Gly Trp Glu Gly Ser Pro Leu Pro Arg Ser
            20                  25                  30          
Pro Thr Gln Asp Ala Ala Gly Val Gly Pro Pro Ala Ser Gln Gly Arg
        35                  40                  45              
Gly Pro Ala Gly Glu Pro Met Gly Pro Glu Ala Gly Ser Lys Ala Glu
    50                  55                  60                  
Leu Pro Pro Thr Val Ser Arg Pro Pro Leu Leu Arg Gly Leu Ser Trp
65                  70                  75                  80  
Asp Ser Gly Pro Glu Glu Pro Gly Pro Arg Leu Gln Lys Val Leu Ala
                85                  90                  95      
Lys Leu Pro Leu Ala Glu Glu Glu Lys Arg Phe Ala Gly Lys Ala Gly
            100                 105                 110         
Gly Lys Leu Ala Lys Ala Pro Gly Leu Lys Asp Phe Gln Ile Gln Val
        115                 120                 125             
Gln Pro Val Arg Met Gln Lys Leu Thr Lys Leu Arg Glu Glu His Ile
    130                 135                 140                 
Leu Met Arg Asn Gln Asn Leu Val Gly Leu Lys Leu Pro Asp Leu Ser
145                 150                 155                 160 
Glu Ala Ala Glu Gln Glu Lys Gly Leu Pro Ser Glu Leu Ser Pro Ala
                165                 170                 175     
Ile Glu Glu Glu Glu Ser Lys Ser Gly Leu Asp Val Met Pro Asn Ile
            180                 185                 190         
Ser Asp Val Leu Leu Arg Lys Leu Arg Val His Arg Ser Leu Pro Gly
        195                 200                 205             
Ser Ala Pro Pro Leu Thr Glu Lys Glu Val Glu Asn Val Phe Val Gln
    210                 215                 220                 
Leu Ser Leu Ala Phe Arg Asn Asp Ser Tyr Thr Leu Glu Ser Arg Ile
225                 230                 235                 240 
Asn Gln Ala Glu Arg Glu Arg Asn Leu Thr Glu Glu Asn Thr Glu Lys
                245                 250                 255     
Glu Leu Glu Asn Phe Lys Ala Ser Ile Thr Ser Ser Ala Ser Leu Trp
            260                 265                 270         
His His Cys Glu His Arg Glu Thr Tyr Gln Lys Leu Leu Glu Asp Ile
        275                 280                 285             
Ala Val Leu His Arg Leu Ala Ala Arg Leu Ser Ser Arg Ala Glu Val
    290                 295                 300                 
Val Gly Ala Val Arg Gln Glu Lys Arg Met Ser Lys Ala Thr Glu Val
305                 310                 315                 320 
Met Met Gln Tyr Val Glu Asn Leu Lys Arg Thr Tyr Glu Lys Asp His
                325                 330                 335     
Ala Glu Leu Met Glu Phe Lys Lys Leu Ala Asn Gln Asn Ser Ser Arg
            340                 345                 350         
Ser Cys Gly Pro Ser Glu Asp Gly Val Pro Arg Thr Ala Arg Ser Met
        355                 360                 365             
Ser Leu Thr Leu Gly Lys Asn Met Pro Arg Arg Arg Val Ser Val Ala
    370                 375                 380                 
Val Val Pro Lys Phe Asn Ala Leu Asn Leu Pro Gly Gln Thr Pro Ser
385                 390                 395                 400 
Ser Ser Ser Ile Pro Ser Leu Pro Ala Leu Ser Glu Ser Pro Asn Gly
                405                 410                 415     
Lys Gly Ser Leu Pro Val Thr Ser Ala Leu Pro Ala Leu Leu Glu Asn
            420                 425                 430         
Gly Lys Thr Asn Gly Asp Pro Asp Cys Glu Ala Ser Ala Pro Ala Leu
        435                 440                 445             
Thr Leu Ser Cys Leu Glu Glu Leu Ser Gln Glu Thr Lys Ala Arg Met
    450                 455                 460                 
Glu Glu Glu Ala Tyr Ser Lys Gly Phe Gln Glu Gly Leu Lys Lys Thr
465                 470                 475                 480 
Lys Glu Leu Gln Asp Leu Lys Glu Glu Glu Glu Glu Gln Lys Ser Glu
                485                 490                 495     
Ser Pro Glu Glu Pro Glu Glu Val Glu Glu Thr Glu Glu Glu Glu Lys
            500                 505                 510         
Gly Pro Arg Ser Ser Lys Leu Glu Glu Leu Val His Phe Leu Gln Val
        515                 520                 525             
Met Tyr Pro Lys Leu Cys Gln His Trp Gln Val Ile Trp Met Met Ala
    530                 535                 540                 
Ala Val Met Leu Val Leu Thr Val Val Leu Gly Leu Tyr Asn Ser Tyr
545                 550                 555                 560 
Asn Ser Cys Ala Glu Gln Ala Asp Gly Pro Leu Gly Arg Ser Thr Cys
                565                 570                 575     
Ser Ala Ala Gln Arg Asp Ser Trp Trp Ser Ser Gly Leu Gln His Glu
            580                 585                 590         
Gln Pro Thr Glu Gln
        595         


<210> 2188
<211> 1939
<212> PRT
<213> Homo sapiens

<400> 2188
Met Ser Ser Asp Ser Glu Met Ala Ile Phe Gly Glu Ala Ala Pro Phe
 1               5                  10                  15      
Leu Arg Lys Ser Glu Arg Glu Arg Ile Glu Ala Gln Asn Lys Pro Phe
            20                  25                  30          
Asp Ala Lys Thr Ser Val Phe Val Val Asp Pro Lys Glu Ser Phe Val
        35                  40                  45              
Lys Ala Thr Val Gln Ser Arg Glu Gly Gly Lys Val Thr Ala Lys Thr
    50                  55                  60                  
Glu Ala Gly Ala Thr Val Thr Val Lys Asp Asp Gln Val Phe Pro Met
65                  70                  75                  80  
Asn Pro Pro Lys Tyr Asp Lys Ile Glu Asp Met Ala Met Met Thr His
                85                  90                  95      
Leu His Glu Pro Ala Val Leu Tyr Asn Leu Lys Glu Arg Tyr Ala Ala
            100                 105                 110         
Trp Met Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Thr Val Asn Pro
        115                 120                 125             
Tyr Lys Trp Leu Pro Val Tyr Asn Ala Glu Val Val Thr Ala Tyr Arg
    130                 135                 140                 
Gly Lys Lys Arg Gln Glu Ala Pro Pro His Ile Phe Ser Ile Ser Asp
145                 150                 155                 160 
Asn Ala Tyr Gln Phe Met Leu Thr Asp Arg Glu Asn Gln Ser Ile Leu
                165                 170                 175     
Ile Thr Gly Glu Ser Gly Ala Gly Lys Thr Val Asn Thr Lys Arg Val
            180                 185                 190         
Ile Gln Tyr Phe Ala Thr Ile Ala Val Thr Gly Glu Lys Lys Lys Glu
        195                 200                 205             
Glu Val Thr Ser Gly Lys Met Gln Gly Thr Leu Glu Asp Gln Ile Ile
    210                 215                 220                 
Ser Ala Asn Pro Leu Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Arg
225                 230                 235                 240 
Asn Asp Asn Ser Ser Arg Phe Gly Lys Phe Ile Arg Ile His Phe Gly
                245                 250                 255     
Thr Thr Gly Lys Leu Ala Ser Ala Asp Ile Glu Thr Tyr Leu Leu Glu
            260                 265                 270         
Lys Ser Arg Val Thr Phe Gln Leu Lys Ala Glu Arg Ser Tyr His Ile
        275                 280                 285             
Phe Tyr Gln Ile Met Ser Asn Lys Lys Pro Asp Leu Ile Glu Met Leu
    290                 295                 300                 
Leu Ile Thr Thr Asn Pro Tyr Asp Tyr Ala Phe Val Ser Gln Gly Glu
305                 310                 315                 320 
Ile Thr Val Pro Ser Ile Asp Asp Gln Glu Glu Leu Met Ala Thr Asp
                325                 330                 335     
Ser Ala Ile Glu Ile Leu Gly Phe Thr Ser Asp Glu Arg Val Ser Ile
            340                 345                 350         
Tyr Lys Leu Thr Gly Ala Val Met His Tyr Gly Asn Met Lys Phe Lys
        355                 360                 365             
Gln Lys Gln Arg Glu Glu Gln Ala Glu Pro Asp Gly Thr Glu Val Ala
    370                 375                 380                 
Asp Lys Ala Ala Tyr Leu Gln Asn Leu Asn Ser Ala Asp Leu Leu Lys
385                 390                 395                 400 
Ala Leu Cys Tyr Pro Arg Val Lys Val Gly Asn Glu Tyr Val Thr Lys
                405                 410                 415     
Gly Gln Thr Val Gln Gln Val Tyr Asn Ala Val Gly Ala Leu Ala Lys
            420                 425                 430         
Ala Val Tyr Asp Lys Met Phe Leu Trp Met Val Thr Arg Ile Asn Gln
        435                 440                 445             
Gln Leu Asp Thr Lys Gln Pro Arg Gln Tyr Phe Ile Gly Val Leu Asp
    450                 455                 460                 
Ile Ala Gly Phe Glu Ile Phe Asp Phe Asn Ser Leu Glu Gln Leu Cys
465                 470                 475                 480 
Ile Asn Phe Thr Asn Glu Lys Leu Gln Gln Phe Phe Asn His His Met
                485                 490                 495     
Phe Val Leu Glu Gln Glu Glu Tyr Lys Lys Glu Gly Ile Glu Trp Thr
            500                 505                 510         
Phe Ile Asp Phe Gly Met Asp Leu Ala Ala Cys Ile Glu Leu Ile Glu
        515                 520                 525             
Lys Pro Met Gly Ile Phe Ser Ile Leu Glu Glu Glu Cys Met Phe Pro
    530                 535                 540                 
Lys Ala Thr Asp Thr Ser Phe Lys Asn Lys Leu Tyr Glu Gln His Leu
545                 550                 555                 560 
Gly Lys Ser Asn Asn Phe Gln Lys Pro Lys Pro Ala Lys Gly Lys Pro
                565                 570                 575     
Glu Ala His Phe Ser Leu Ile His Tyr Ala Gly Thr Val Asp Tyr Asn
            580                 585                 590         
Ile Ala Gly Trp Leu Asp Lys Asn Lys Asp Pro Leu Asn Glu Thr Val
        595                 600                 605             
Val Gly Leu Tyr Gln Lys Ser Ala Met Lys Thr Leu Ala Leu Leu Phe
    610                 615                 620                 
Val Gly Ala Thr Gly Ala Glu Ala Glu Ala Gly Gly Gly Lys Lys Gly
625                 630                 635                 640 
Gly Lys Lys Lys Gly Ser Ser Phe Gln Thr Val Ser Ala Leu Phe Arg
                645                 650                 655     
Glu Asn Leu Asn Lys Leu Met Thr Asn Leu Arg Ser Thr His Pro His
            660                 665                 670         
Phe Val Arg Cys Ile Ile Pro Asn Glu Thr Lys Thr Pro Gly Ala Met
        675                 680                 685             
Glu His Glu Leu Val Leu His Gln Leu Arg Cys Asn Gly Val Leu Glu
    690                 695                 700                 
Gly Ile Arg Ile Cys Arg Lys Gly Phe Pro Ser Arg Ile Leu Tyr Ala
705                 710                 715                 720 
Asp Phe Lys Gln Arg Tyr Lys Val Leu Asn Ala Ser Ala Ile Pro Glu
                725                 730                 735     
Gly Gln Phe Ile Asp Ser Lys Lys Ala Ser Glu Lys Leu Leu Gly Ser
            740                 745                 750         
Ile Asp Ile Asp His Thr Gln Tyr Lys Phe Gly His Thr Lys Val Phe
        755                 760                 765             
Phe Lys Ala Gly Leu Leu Gly Leu Leu Glu Glu Met Arg Asp Glu Lys
    770                 775                 780                 
Leu Ala Gln Leu Ile Thr Arg Thr Gln Ala Met Cys Arg Gly Phe Leu
785                 790                 795                 800 
Ala Arg Val Glu Tyr Gln Lys Met Val Glu Arg Arg Glu Ser Ile Phe
                805                 810                 815     
Cys Ile Gln Tyr Asn Val Arg Ala Phe Met Asn Val Lys His Trp Pro
            820                 825                 830         
Trp Met Lys Leu Tyr Phe Lys Ile Lys Pro Leu Leu Lys Ser Ala Glu
        835                 840                 845             
Thr Glu Lys Glu Met Ala Asn Met Lys Glu Glu Phe Glu Lys Thr Lys
    850                 855                 860                 
Glu Glu Leu Ala Lys Thr Glu Ala Lys Arg Lys Glu Leu Glu Glu Lys
865                 870                 875                 880 
Met Val Thr Leu Met Gln Glu Lys Asn Asp Leu Gln Leu Gln Val Gln
                885                 890                 895     
Ala Glu Ala Asp Ser Leu Ala Asp Ala Glu Glu Arg Cys Asp Gln Leu
            900                 905                 910         
Ile Lys Thr Lys Ile Gln Leu Glu Ala Lys Ile Lys Glu Val Thr Glu
        915                 920                 925             
Arg Ala Glu Asp Glu Glu Glu Ile Asn Ala Glu Leu Thr Ala Lys Lys
    930                 935                 940                 
Arg Lys Leu Glu Asp Glu Cys Ser Glu Leu Lys Lys Asp Ile Asp Asp
945                 950                 955                 960 
Leu Glu Leu Thr Leu Ala Lys Val Glu Lys Glu Lys His Ala Thr Glu
                965                 970                 975     
Asn Lys Val Lys Asn Leu Thr Glu Glu Met Ala Gly Leu Asp Glu Thr
            980                 985                 990         
Ile Ala Lys Leu Thr Lys Glu Lys Lys Ala Leu Gln Glu Ala His Gln
        995                 1000                1005            
Gln Thr Leu Asp Asp Leu Gln Ala Glu Glu Asp Lys Val Asn Thr Leu
    1010                1015                1020                
Thr Lys Ala Lys Ile Lys Leu Glu Gln Gln Val Asp Asp Leu Glu Gly
1025                1030                1035                1040
Ser Leu Glu Gln Glu Lys Lys Ile Arg Met Asp Leu Glu Arg Ala Lys
                1045                1050                1055    
Arg Lys Leu Glu Gly Asp Leu Lys Leu Ala Gln Glu Ser Thr Met Asp
            1060                1065                1070        
Ile Glu Asn Asp Lys Gln Gln Leu Asp Glu Lys Leu Lys Lys Lys Glu
        1075                1080                1085            
Phe Glu Met Ser Gly Leu Gln Ser Lys Ile Glu Asp Glu Gln Ala Leu
    1090                1095                1100                
Gly Met Gln Leu Gln Lys Lys Ile Lys Glu Leu Gln Ala Arg Ile Glu
1105                1110                1115                1120
Glu Leu Glu Glu Glu Ile Glu Ala Glu Arg Ala Ser Arg Ala Lys Ala
                1125                1130                1135    
Glu Lys Gln Arg Ser Asp Leu Ser Arg Glu Leu Glu Glu Ile Ser Glu
            1140                1145                1150        
Arg Leu Glu Glu Ala Gly Gly Ala Thr Ser Ala Gln Ile Glu Met Asn
        1155                1160                1165            
Lys Lys Arg Glu Ala Glu Phe Gln Lys Met Arg Arg Asp Leu Glu Glu
    1170                1175                1180                
Ala Thr Leu Gln His Glu Ala Thr Ala Ala Thr Leu Arg Lys Lys His
1185                1190                1195                1200
Ala Asp Ser Val Ala Glu Leu Gly Glu Gln Ile Asp Asn Leu Gln Arg
                1205                1210                1215    
Val Lys Gln Lys Leu Glu Lys Glu Lys Ser Glu Met Lys Met Glu Ile
            1220                1225                1230        
Asp Asp Leu Ala Ser Asn Met Glu Thr Val Ser Lys Ala Lys Gly Asn
        1235                1240                1245            
Leu Glu Lys Met Cys Arg Ala Leu Glu Asp Gln Leu Ser Glu Ile Lys
    1250                1255                1260                
Thr Lys Glu Glu Glu Gln Gln Arg Leu Ile Asn Asp Leu Thr Ala Gln
1265                1270                1275                1280
Arg Ala Arg Leu Gln Thr Glu Ser Gly Glu Tyr Ser Arg Gln Leu Asp
                1285                1290                1295    
Glu Lys Asp Thr Leu Val Ser Gln Leu Ser Arg Gly Lys Gln Ala Phe
            1300                1305                1310        
Thr Gln Gln Ile Glu Glu Leu Lys Arg Gln Leu Glu Glu Glu Ile Lys
        1315                1320                1325            
Ala Lys Ser Ala Leu Ala His Ala Leu Gln Ser Ser Arg His Asp Cys
    1330                1335                1340                
Asp Leu Leu Arg Glu Gln Tyr Glu Glu Glu Gln Glu Ala Lys Ala Glu
1345                1350                1355                1360
Leu Gln Arg Ala Met Ser Lys Ala Asn Ser Glu Val Ala Gln Trp Arg
                1365                1370                1375    
Thr Lys Tyr Glu Thr Asp Ala Ile Gln Arg Thr Glu Glu Leu Glu Glu
            1380                1385                1390        
Ala Lys Lys Lys Leu Ala Gln Arg Leu Gln Asp Ala Glu Glu His Val
        1395                1400                1405            
Glu Ala Val Asn Ala Lys Cys Ala Ser Leu Glu Lys Thr Lys Gln Arg
    1410                1415                1420                
Leu Gln Asn Glu Val Glu Asp Leu Met Ile Asp Val Glu Arg Thr Asn
1425                1430                1435                1440
Ala Ala Cys Ala Ala Leu Asp Lys Lys Gln Arg Asn Phe Asp Lys Ile
                1445                1450                1455    
Leu Ala Glu Trp Lys Gln Lys Cys Glu Glu Thr His Ala Glu Leu Glu
            1460                1465                1470        
Ala Ser Gln Lys Glu Ser Arg Ser Leu Ser Thr Glu Leu Phe Lys Ile
        1475                1480                1485            
Lys Asn Ala Tyr Glu Glu Ser Leu Asp Gln Leu Glu Thr Leu Lys Arg
    1490                1495                1500                
Glu Asn Lys Asn Leu Gln Gln Glu Ile Ser Asp Leu Thr Glu Gln Ile
1505                1510                1515                1520
Ala Glu Gly Gly Lys Arg Ile His Glu Leu Glu Lys Ile Lys Lys Gln
                1525                1530                1535    
Val Glu Gln Glu Lys Ser Glu Leu Gln Ala Ala Leu Glu Glu Ala Glu
            1540                1545                1550        
Ala Ser Leu Glu His Glu Glu Gly Lys Ile Leu Arg Ile Gln Leu Glu
        1555                1560                1565            
Leu Asn Gln Val Lys Ser Glu Val Asp Arg Lys Ile Ala Glu Lys Asp
    1570                1575                1580                
Glu Glu Ile Asp Gln Met Lys Arg Asn His Ile Arg Ile Val Glu Ser
1585                1590                1595                1600
Met Gln Ser Thr Leu Asp Ala Glu Ile Arg Ser Arg Asn Asp Ala Ile
                1605                1610                1615    
Arg Leu Lys Lys Lys Met Glu Gly Asp Leu Asn Glu Met Glu Ile Gln
            1620                1625                1630        
Leu Asn His Ala Asn Arg Met Ala Ala Glu Ala Leu Arg Asn Tyr Arg
        1635                1640                1645            
Asn Thr Gln Ala Ile Leu Lys Asp Thr Gln Leu His Leu Asp Asp Ala
    1650                1655                1660                
Leu Arg Ser Gln Glu Asp Leu Lys Glu Gln Leu Ala Met Val Glu Arg
1665                1670                1675                1680
Arg Ala Asn Leu Leu Gln Ala Glu Ile Glu Glu Leu Arg Ala Thr Leu
                1685                1690                1695    
Glu Gln Thr Glu Arg Ser Arg Lys Ile Ala Glu Gln Glu Leu Leu Asp
            1700                1705                1710        
Ala Ser Glu Arg Val Gln Leu Leu His Thr Gln Asn Thr Ser Leu Ile
        1715                1720                1725            
Asn Thr Lys Lys Lys Leu Glu Thr Asp Ile Ser Gln Ile Gln Gly Glu
    1730                1735                1740                
Met Glu Asp Ile Ile Gln Glu Ala Arg Asn Ala Glu Glu Lys Ala Lys
1745                1750                1755                1760
Lys Ala Ile Thr Asp Ala Ala Met Met Ala Glu Glu Leu Lys Lys Glu
                1765                1770                1775    
Gln Asp Thr Ser Ala His Leu Glu Arg Met Lys Lys Asn Leu Glu Gln
            1780                1785                1790        
Thr Val Lys Asp Leu Gln His Arg Leu Asp Glu Ala Glu Gln Leu Ala
        1795                1800                1805            
Leu Lys Gly Gly Lys Lys Gln Ile Gln Lys Leu Glu Ala Arg Val Arg
    1810                1815                1820                
Glu Leu Glu Gly Glu Val Glu Ser Glu Gln Lys Arg Asn Val Glu Ala
1825                1830                1835                1840
Val Lys Gly Leu Arg Lys His Glu Arg Lys Val Lys Glu Leu Thr Tyr
                1845                1850                1855    
Gln Thr Glu Glu Asp Arg Lys Asn Ile Leu Arg Leu Gln Asp Leu Val
            1860                1865                1870        
Asp Lys Leu Gln Ala Lys Val Lys Ser Tyr Lys Arg Gln Ala Glu Glu
        1875                1880                1885            
Ala Glu Glu Gln Ser Asn Val Asn Leu Ser Lys Phe Arg Arg Ile Gln
    1890                1895                1900                
His Glu Leu Glu Glu Ala Glu Glu Arg Ala Asp Ile Ala Glu Ser Gln
1905                1910                1915                1920
Val Asn Lys Leu Arg Val Lys Ser Arg Glu Val His Thr Lys Ile Ile
                1925                1930                1935    
Ser Glu Glu
            


<210> 2189
<211> 360
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 193, 194, 195, 196, 197
<223> Xaa = Any Amino Acid

<400> 2189
Met Arg Ala Thr Pro Leu Ala Ala Pro Ala Gly Ser Leu Ser Arg Lys
 1               5                  10                  15      
Lys Arg Leu Glu Leu Asp Asp Asn Leu Asp Thr Glu Arg Pro Val Gln
            20                  25                  30          
Lys Arg Ala Arg Ser Gly Pro Gln Pro Arg Leu Pro Pro Cys Leu Leu
        35                  40                  45              
Pro Leu Ser Pro Pro Thr Ala Pro Asp Arg Ala Thr Ala Val Ala Thr
    50                  55                  60                  
Ala Ser Arg Leu Gly Pro Tyr Val Leu Leu Glu Pro Glu Glu Gly Gly
65                  70                  75                  80  
Arg Ala Tyr Gln Ala Leu His Cys Pro Thr Gly Thr Glu Tyr Thr Cys
                85                  90                  95      
Lys Val Tyr Pro Val Gln Glu Ala Leu Ala Val Leu Glu Pro Tyr Ala
            100                 105                 110         
Arg Leu Pro Pro His Lys His Val Ala Arg Pro Thr Glu Val Leu Ala
        115                 120                 125             
Gly Thr Gln Leu Leu Tyr Ala Phe Phe Thr Arg Thr His Gly Asp Met
    130                 135                 140                 
His Ser Leu Val Arg Ser Arg His Arg Ile Pro Glu Pro Glu Ala Ala
145                 150                 155                 160 
Val Leu Phe Arg Gln Met Ala Thr Ala Leu Ala His Cys His Gln His
                165                 170                 175     
Gly Leu Val Leu Arg Asp Leu Lys Leu Cys Arg Phe Val Phe Ala Asp
            180                 185                 190         
Xaa Xaa Xaa Xaa Xaa Lys Lys Leu Val Leu Glu Asn Leu Glu Asp Ser
        195                 200                 205             
Cys Val Leu Thr Gly Pro Asp Asp Ser Leu Trp Asp Lys His Ala Cys
    210                 215                 220                 
Pro Ala Tyr Val Gly Pro Glu Ile Leu Ser Ser Arg Ala Ser Tyr Ser
225                 230                 235                 240 
Gly Lys Ala Ala Asp Val Trp Ser Leu Gly Val Ala Leu Phe Thr Met
                245                 250                 255     
Leu Ala Gly His Tyr Pro Phe Gln Asp Ser Glu Pro Val Leu Leu Phe
            260                 265                 270         
Gly Lys Ile Arg Arg Gly Ala Tyr Ala Leu Pro Ala Gly Leu Ser Ala
        275                 280                 285             
Pro Ala Arg Cys Leu Val Arg Cys Leu Leu Arg Arg Glu Pro Ala Glu
    290                 295                 300                 
Arg Leu Thr Ala Thr Gly Ile Leu Leu His Pro Trp Leu Arg Gln Asp
305                 310                 315                 320 
Pro Met Pro Leu Ala Pro Thr Arg Ser His Leu Trp Glu Ala Ala Gln
                325                 330                 335     
Val Val Pro Asp Gly Leu Gly Leu Asp Glu Ala Arg Glu Glu Glu Gly
            340                 345                 350         
Asp Arg Glu Val Val Leu Tyr Gly
        355                 360 


<210> 2190
<211> 863
<212> PRT
<213> Homo sapiens

<400> 2190
Met Ala Lys Pro Leu Thr Asp Ser Glu Lys Arg Lys Gln Ile Ser Val
 1               5                  10                  15      
Arg Gly Leu Ala Gly Leu Gly Asp Val Ala Glu Val Arg Lys Ser Phe
            20                  25                  30          
Asn Arg His Leu His Phe Thr Leu Val Lys Asp Arg Asn Val Ala Thr
        35                  40                  45              
Pro Arg Asp Tyr Phe Phe Ala Leu Ala His Thr Val Arg Asp His Leu
    50                  55                  60                  
Val Gly Arg Trp Ile Arg Thr Gln Gln His Tyr Tyr Glu Arg Asp Pro
65                  70                  75                  80  
Lys Arg Ile Tyr Tyr Leu Ser Leu Glu Phe Tyr Met Gly Arg Thr Leu
                85                  90                  95      
Gln Asn Thr Met Val Asn Leu Gly Leu Gln Asn Ala Cys Asp Glu Ala
            100                 105                 110         
Ile Tyr Gln Leu Gly Leu Asp Leu Glu Glu Leu Glu Glu Ile Glu Glu
        115                 120                 125             
Asp Ala Gly Leu Gly Asn Gly Gly Leu Gly Arg Leu Ala Ala Cys Phe
    130                 135                 140                 
Leu Asp Ser Met Ala Thr Leu Gly Leu Ala Ala Tyr Gly Tyr Gly Ile
145                 150                 155                 160 
Arg Tyr Glu Phe Gly Ile Phe Asn Gln Lys Ile Val Asn Gly Trp Gln
                165                 170                 175     
Val Glu Glu Ala Asp Asp Trp Leu Arg Tyr Gly Asn Pro Trp Glu Lys
            180                 185                 190         
Ala Arg Pro Glu Tyr Met Leu Pro Val His Phe Tyr Gly Arg Val Glu
        195                 200                 205             
His Thr Pro Asp Gly Val Lys Trp Leu Asp Thr Gln Val Val Leu Ala
    210                 215                 220                 
Met Pro Tyr Asp Thr Pro Val Pro Gly Tyr Lys Asn Asn Thr Val Asn
225                 230                 235                 240 
Thr Met Arg Leu Trp Ser Ala Lys Ala Pro Asn Asp Phe Lys Leu Gln
                245                 250                 255     
Asp Phe Asn Val Gly Asp Tyr Ile Glu Ala Val Leu Asp Arg Asn Leu
            260                 265                 270         
Ala Glu Asn Ile Ser Arg Val Leu Tyr Pro Asn Asp Asn Phe Phe Glu
        275                 280                 285             
Gly Lys Glu Leu Arg Leu Lys Gln Glu Tyr Phe Val Val Ala Ala Thr
    290                 295                 300                 
Leu Gln Asp Ile Ile Arg Arg Phe Lys Ser Ser Lys Phe Gly Cys Arg
305                 310                 315                 320 
Asp Pro Val Arg Thr Cys Phe Glu Thr Phe Pro Asp Lys Val Ala Ile
                325                 330                 335     
Gln Leu Asn Asp Thr His Pro Ala Leu Ser Ile Pro Glu Leu Met Arg
            340                 345                 350         
Ile Leu Val Asp Val Glu Lys Val Asp Trp Asp Lys Ala Trp Glu Ile
        355                 360                 365             
Thr Lys Lys Thr Cys Ala Tyr Thr Asn His Thr Val Leu Pro Glu Ala
    370                 375                 380                 
Leu Glu Arg Trp Pro Val Ser Met Phe Glu Lys Leu Leu Pro Arg His
385                 390                 395                 400 
Leu Glu Ile Ile Tyr Ala Ile Asn Gln Arg His Leu Asp His Val Ala
                405                 410                 415     
Ala Leu Phe Pro Gly Asp Val Asp Arg Leu Arg Arg Met Ser Val Ile
            420                 425                 430         
Glu Glu Gly Asp Cys Lys Arg Ile Asn Met Ala His Leu Cys Val Ile
        435                 440                 445             
Gly Ser His Ala Val Asn Gly Val Ala Arg Ile His Ser Glu Ile Val
    450                 455                 460                 
Lys Gln Ser Val Phe Lys Asp Phe Tyr Glu Leu Glu Pro Glu Lys Phe
465                 470                 475                 480 
Gln Asn Lys Thr Asn Gly Ile Thr Pro Arg Arg Trp Leu Leu Leu Cys
                485                 490                 495     
Asn Pro Gly Leu Ala Asp Thr Ile Val Glu Lys Ile Gly Glu Glu Phe
            500                 505                 510         
Leu Thr Asp Leu Ser Gln Leu Lys Lys Leu Leu Pro Leu Val Ser Asp
        515                 520                 525             
Glu Val Phe Ile Arg Asp Val Ala Lys Val Lys Gln Glu Asn Lys Leu
    530                 535                 540                 
Lys Phe Ser Ala Phe Leu Glu Lys Glu Tyr Lys Val Lys Ile Asn Pro
545                 550                 555                 560 
Ser Ser Met Phe Asp Val His Val Lys Arg Ile His Glu Tyr Lys Arg
                565                 570                 575     
Gln Leu Leu Asn Cys Leu His Val Val Thr Leu Tyr Asn Arg Ile Lys
            580                 585                 590         
Arg Asp Pro Ala Lys Ala Phe Val Pro Arg Thr Val Met Ile Gly Gly
        595                 600                 605             
Lys Ala Ala Pro Gly Tyr His Met Ala Lys Leu Ile Ile Lys Leu Val
    610                 615                 620                 
Thr Ser Ile Gly Asp Val Val Asn His Asp Pro Val Val Gly Asp Arg
625                 630                 635                 640 
Leu Lys Val Ile Phe Leu Glu Asn Tyr Arg Val Ser Leu Ala Glu Lys
                645                 650                 655     
Val Ile Pro Ala Ala Asp Leu Ser Gln Gln Ile Ser Thr Ala Gly Thr
            660                 665                 670         
Glu Ala Ser Gly Thr Gly Asn Met Lys Phe Met Leu Asn Gly Ala Leu
        675                 680                 685             
Thr Ile Gly Thr Met Asp Gly Ala Asn Val Glu Met Ala Glu Glu Ala
    690                 695                 700                 
Gly Ala Glu Asn Leu Phe Ile Phe Gly Leu Arg Val Glu Asp Val Glu
705                 710                 715                 720 
Ala Leu Asp Arg Lys Gly Tyr Asn Ala Arg Glu Tyr Tyr Asp His Leu
                725                 730                 735     
Pro Glu Leu Lys Gln Ala Val Asp Gln Ile Ser Ser Gly Phe Phe Ser
            740                 745                 750         
Pro Lys Glu Pro Asp Cys Phe Lys Asp Ile Val Asn Met Leu Met His
        755                 760                 765             
His Asp Arg Phe Lys Val Phe Ala Asp Tyr Glu Ala Tyr Met Gln Cys
    770                 775                 780                 
Gln Ala Gln Val Asp Gln Leu Tyr Arg Asn Pro Lys Glu Trp Thr Lys
785                 790                 795                 800 
Lys Val Ile Arg Asn Ile Ala Cys Ser Gly Lys Phe Ser Ser Asp Arg
                805                 810                 815     
Thr Ile Thr Glu Tyr Ala Arg Glu Ile Trp Gly Val Glu Pro Ser Asp
            820                 825                 830         
Leu Gln Leu Gln His Leu Pro His Pro Glu Trp Glu Ser Gly Gly Ala
        835                 840                 845             
Thr Cys Trp Ala Pro Pro Glu Leu Cys Thr His Leu Ala Met Tyr
    850                 855                 860             


<210> 2191
<211> 727
<212> PRT
<213> Homo sapiens

<400> 2191
Met Asn Gly Glu Ala Asp Cys Pro Thr Asp Leu Glu Met Ala Ala Pro
 1               5                  10                  15      
Lys Gly Gln Asp Arg Trp Ser Gln Glu Asp Met Leu Thr Leu Leu Glu
            20                  25                  30          
Cys Met Lys Asn Asn Leu Pro Ser Asn Asp Ser Ser Lys Phe Lys Thr
        35                  40                  45              
Thr Glu Ser His Met Asp Trp Glu Lys Val Ala Phe Lys Asp Phe Ser
    50                  55                  60                  
Gly Asp Met Cys Lys Leu Lys Trp Val Glu Ile Ser Asn Glu Val Arg
65                  70                  75                  80  
Lys Phe Arg Thr Leu Thr Glu Leu Ile Leu Asp Ala Gln Glu His Val
                85                  90                  95      
Lys Asn Pro Tyr Lys Gly Lys Lys Leu Lys Lys His Pro Asp Phe Pro
            100                 105                 110         
Lys Lys Pro Leu Thr Pro Tyr Phe Arg Phe Phe Met Glu Lys Arg Ala
        115                 120                 125             
Lys Tyr Ala Lys Leu His Pro Glu Met Ser Asn Leu Asp Leu Thr Lys
    130                 135                 140                 
Ile Leu Ser Lys Lys Tyr Lys Glu Leu Pro Glu Lys Lys Lys Met Lys
145                 150                 155                 160 
Tyr Ile Gln Asp Phe Gln Arg Glu Lys Gln Glu Phe Glu Arg Asn Leu
                165                 170                 175     
Ala Arg Phe Arg Glu Asp His Pro Asp Leu Ile Gln Asn Ala Lys Lys
            180                 185                 190         
Ser Asp Ile Pro Glu Lys Pro Lys Thr Pro Gln Gln Leu Trp Tyr Thr
        195                 200                 205             
His Glu Lys Lys Val Tyr Leu Lys Val Arg Pro Asp Glu Ile Met Arg
    210                 215                 220                 
Asp Tyr Ile Gln Lys His Pro Glu Leu Asn Ile Ser Glu Glu Gly Ile
225                 230                 235                 240 
Thr Lys Ser Thr Leu Thr Lys Ala Glu Arg Gln Leu Lys Asp Lys Phe
                245                 250                 255     
Asp Gly Arg Pro Thr Lys Pro Pro Pro Asn Ser Tyr Ser Leu Tyr Cys
            260                 265                 270         
Ala Glu Leu Met Ala Asn Met Lys Asp Val Pro Ser Thr Glu Arg Met
        275                 280                 285             
Val Leu Cys Ser Gln Gln Trp Lys Leu Leu Ser Gln Lys Glu Lys Asp
    290                 295                 300                 
Ala Tyr His Lys Lys Cys Asp Gln Lys Lys Lys Asp Tyr Glu Val Glu
305                 310                 315                 320 
Leu Leu Arg Phe Leu Glu Ser Leu Pro Glu Glu Glu Gln Gln Arg Val
                325                 330                 335     
Leu Gly Glu Glu Lys Met Leu Asn Ile Asn Lys Lys Gln Ala Thr Ser
            340                 345                 350         
Pro Ala Ser Lys Lys Pro Ala Gln Glu Gly Gly Lys Gly Gly Ser Glu
        355                 360                 365             
Lys Pro Lys Arg Pro Val Ser Ala Met Phe Ile Phe Ser Glu Glu Lys
    370                 375                 380                 
Arg Arg Gln Leu Gln Glu Glu Arg Pro Glu Leu Ser Glu Ser Glu Leu
385                 390                 395                 400 
Thr Arg Leu Leu Ala Arg Met Trp Asn Asp Leu Ser Glu Lys Lys Lys
                405                 410                 415     
Ala Lys Tyr Lys Ala Arg Glu Ala Ala Leu Lys Ala Gln Ser Glu Arg
            420                 425                 430         
Lys Pro Gly Gly Glu Arg Glu Glu Arg Gly Lys Leu Pro Glu Ser Pro
        435                 440                 445             
Lys Arg Ala Glu Glu Ile Trp Gln Gln Ser Val Ile Gly Asp Tyr Leu
    450                 455                 460                 
Ala Arg Phe Lys Asn Asp Arg Val Lys Ala Leu Lys Ala Met Glu Met
465                 470                 475                 480 
Thr Trp Asn Asn Met Glu Lys Lys Glu Lys Leu Met Trp Ile Lys Lys
                485                 490                 495     
Ala Ala Glu Asp Gln Lys Arg Tyr Glu Arg Glu Leu Ser Glu Met Arg
            500                 505                 510         
Ala Pro Pro Ala Ala Thr Asn Ser Ser Lys Lys Met Lys Phe Gln Gly
        515                 520                 525             
Glu Pro Lys Lys Pro Pro Met Asn Gly Tyr Gln Lys Phe Ser Gln Glu
    530                 535                 540                 
Leu Leu Ser Asn Gly Glu Leu Asn His Leu Pro Leu Lys Glu Arg Met
545                 550                 555                 560 
Val Glu Ile Gly Ser Arg Trp Gln Arg Ile Ser Gln Ser Gln Lys Glu
                565                 570                 575     
His Tyr Lys Lys Leu Ala Glu Glu Gln Gln Lys Gln Tyr Lys Val His
            580                 585                 590         
Leu Asp Leu Trp Val Lys Ser Leu Ser Pro Gln Asp Arg Ala Ala Tyr
        595                 600                 605             
Lys Glu Tyr Ile Ser Asn Lys Arg Lys Ser Met Thr Lys Leu Arg Gly
    610                 615                 620                 
Pro Asn Pro Lys Ser Ser Arg Thr Thr Leu Gln Ser Lys Ser Glu Ser
625                 630                 635                 640 
Glu Glu Asp Asp Glu Glu Asp Glu Asp Asp Glu Asp Glu Asp Glu Glu
                645                 650                 655     
Glu Glu Asp Asp Glu Asn Gly Asp Ser Ser Glu Asp Gly Gly Asp Ser
            660                 665                 670         
Ser Glu Ser Ser Ser Glu Asp Glu Ser Glu Asp Gly Asp Glu Asn Glu
        675                 680                 685             
Glu Asp Asp Glu Asp Glu Asp Asp Asp Glu Asp Asp Asp Glu Asp Glu
    690                 695                 700                 
Asp Asn Glu Ser Glu Gly Ser Ser Ser Ser Ser Ser Ser Ser Gly Asp
705                 710                 715                 720 
Ser Ser Asp Ser Asp Ser Asn
                725         


<210> 2192
<211> 442
<212> PRT
<213> Homo sapiens

<400> 2192
Met Lys Ile Arg Ala Glu Asn Lys Trp Leu Gln Met Leu Pro Thr Thr
 1               5                  10                  15      
Arg Ala Ala Trp Lys Met Ala Val Cys Leu Val Ala Gly Lys Thr Pro
            20                  25                  30          
Cys Pro Ser Thr Leu Ser Leu Arg Gly Gly Ser Val Arg His Ala Gly
        35                  40                  45              
Ile Ala Ser Leu Ser Cys Phe Thr Cys Met Met Thr Met Ala Ile Ser
    50                  55                  60                  
Leu Thr Ala Leu Cys Ala Ala Arg Ala Glu Ser Cys Cys Phe Ala Ala
65                  70                  75                  80  
Thr Arg Ala Ala Ala Gly Val Ser Val Trp Ser Ala Trp Arg Cys Trp
                85                  90                  95      
Trp Ala Gln Ala Gln Arg Pro Arg Pro Ser Phe Arg Ser Pro Gly Ala
            100                 105                 110         
Val Thr Cys Val Ser Arg Ser Ala Val Met Ala Ser Cys Gly Ala Gly
        115                 120                 125             
Arg Thr Gly Thr Cys Ala Cys Arg Pro Ser Ser Pro Val Thr Arg Gly
    130                 135                 140                 
Leu Asn Met Glu Ala Pro Lys Leu Tyr Pro Ala Ile Pro Ala Ala Arg
145                 150                 155                 160 
Arg Arg Pro Ile Arg Val Leu Ser Leu Phe Asp Gly Ile Ala Thr Gly
                165                 170                 175     
Tyr Leu Val Leu Lys Glu Leu Gly Ile Lys Val Gly Lys Tyr Val Ala
            180                 185                 190         
Ser Glu Val Cys Glu Glu Ser Ile Ala Val Gly Thr Val Lys His Glu
        195                 200                 205             
Gly Asn Ile Lys Tyr Val Asn Asp Val Arg Asn Ile Thr Lys Lys Asn
    210                 215                 220                 
Ile Glu Glu Trp Gly Pro Phe Asp Leu Val Ile Gly Gly Ser Pro Cys
225                 230                 235                 240 
Asn Asp Leu Ser Asn Val Asn Pro Ala Arg Lys Gly Leu Tyr Glu Gly
                245                 250                 255     
Thr Gly Arg Leu Phe Phe Glu Phe Tyr His Leu Leu Asn Tyr Ser Arg
            260                 265                 270         
Pro Lys Glu Gly Asp Asp Arg Pro Phe Phe Trp Met Phe Glu Asn Val
        275                 280                 285             
Val Ala Met Lys Val Gly Asp Lys Arg Asp Ile Ser Arg Phe Leu Glu
    290                 295                 300                 
Cys Asn Pro Val Met Ile Asp Ala Ile Lys Val Ser Ala Ala His Arg
305                 310                 315                 320 
Ala Arg Tyr Phe Trp Gly Asn Leu Pro Gly Met Asn Arg Pro Val Ile
                325                 330                 335     
Ala Ser Lys Asn Asp Lys Leu Glu Leu Gln Asp Cys Leu Glu Tyr Asn
            340                 345                 350         
Arg Ile Ala Lys Leu Lys Lys Val Gln Thr Ile Thr Thr Lys Ser Asn
        355                 360                 365             
Ser Ile Lys Gln Gly Lys Asn Gln Leu Phe Pro Val Val Met Asn Gly
    370                 375                 380                 
Lys Glu Asp Val Leu Trp Cys Thr Glu Leu Glu Arg Ile Phe Gly Phe
385                 390                 395                 400 
Pro Val His Tyr Thr Asp Val Ser Asn Met Gly Arg Gly Ala Arg Gln
                405                 410                 415     
Lys Leu Leu Gly Arg Ser Trp Ser Val Pro Val Ile Arg His Leu Phe
            420                 425                 430         
Ala Pro Leu Lys Asp Tyr Phe Ala Cys Glu
        435                 440         


<210> 2193
<211> 640
<212> PRT
<213> Homo sapiens

<400> 2193
Met Phe Ser Cys Val Lys Pro Tyr Glu Asp Gln Asn Tyr Ser Ala Leu
 1               5                  10                  15      
Arg Arg Asp Cys Arg Arg Arg Lys Val Leu Phe Glu Asp Pro Leu Phe
            20                  25                  30          
Pro Ala Thr Asp Asp Ser Leu Tyr Tyr Lys Gly Thr Pro Gly Pro Ala
        35                  40                  45              
Val Arg Trp Lys Arg Pro Lys Gly Ile Cys Glu Asp Pro Arg Leu Phe
    50                  55                  60                  
Val Asp Gly Ile Ser Ser His Asp Leu His Gln Gly Gln Val Gly Asn
65                  70                  75                  80  
Cys Trp Phe Val Ala Ala Cys Ser Ser Leu Ala Ser Arg Glu Ser Leu
                85                  90                  95      
Trp Gln Lys Val Ile Pro Asp Trp Lys Glu Gln Glu Trp Asp Pro Glu
            100                 105                 110         
Lys Pro Asn Ala Tyr Ala Gly Ile Phe His Phe His Phe Trp Arg Phe
        115                 120                 125             
Gly Glu Trp Val Asp Val Val Ile Asp Asp Arg Leu Pro Thr Val Asn
    130                 135                 140                 
Asn Gln Leu Ile Tyr Cys His Ser Asn Ser Arg Asn Glu Phe Trp Cys
145                 150                 155                 160 
Ala Leu Val Glu Lys Ala Tyr Ala Lys Leu Ala Gly Cys Tyr Gln Ala
                165                 170                 175     
Leu Asp Gly Gly Asn Thr Ala Asp Ala Leu Val Asp Phe Thr Gly Gly
            180                 185                 190         
Val Ser Glu Pro Ile Asp Leu Thr Glu Gly Asp Phe Ala Asn Asp Glu
        195                 200                 205             
Thr Lys Arg Asn Gln Leu Phe Glu Arg Met Leu Lys Val His Ser Arg
    210                 215                 220                 
Gly Gly Leu Ile Ser Ala Ser Ile Lys Ala Val Thr Ala Ala Asp Met
225                 230                 235                 240 
Glu Ala Arg Leu Ala Cys Gly Leu Val Lys Gly His Ala Tyr Ala Val
                245                 250                 255     
Thr Asp Val Arg Lys Val Arg Leu Gly His Gly Leu Leu Ala Phe Phe
            260                 265                 270         
Lys Ser Glu Lys Leu Asp Met Ile Arg Leu Arg Asn Pro Trp Gly Glu
        275                 280                 285             
Arg Glu Trp Asn Gly Pro Trp Ser Asp Thr Ser Glu Glu Trp Gln Lys
    290                 295                 300                 
Val Ser Lys Ser Glu Arg Glu Lys Met Gly Val Thr Val Gln Asp Asp
305                 310                 315                 320 
Gly Glu Phe Trp Met Thr Phe Glu Asp Val Cys Arg Tyr Phe Thr Asp
                325                 330                 335     
Ile Ile Lys Cys Arg Val Ile Asn Thr Ser His Leu Ser Ile His Lys
            340                 345                 350         
Thr Trp Glu Glu Ala Arg Leu His Gly Ala Trp Thr Leu His Glu Asp
        355                 360                 365             
Pro Arg Gln Asn Arg Gly Gly Gly Cys Ile Asn His Lys Asp Thr Phe
    370                 375                 380                 
Phe Gln Asn Pro Gln Tyr Ile Phe Glu Val Lys Lys Pro Glu Asp Glu
385                 390                 395                 400 
Val Leu Ile Cys Ile Gln Gln Arg Pro Lys Arg Ser Thr Arg Arg Glu
                405                 410                 415     
Gly Lys Gly Glu Asn Leu Ala Ile Gly Phe Asp Ile Tyr Lys Val Glu
            420                 425                 430         
Glu Asn Arg Gln Tyr Arg Met His Ser Leu Gln His Lys Ala Ala Ser
        435                 440                 445             
Ser Ile Tyr Ile Asn Ser Arg Ser Val Phe Leu Arg Thr Asp Gln Pro
    450                 455                 460                 
Glu Gly Arg Tyr Val Ile Ile Pro Thr Thr Phe Glu Pro Gly His Thr
465                 470                 475                 480 
Gly Glu Phe Leu Leu Arg Val Phe Thr Asp Val Pro Ser Asn Cys Arg
                485                 490                 495     
Glu Leu Arg Leu Asp Glu Pro Pro His Thr Cys Trp Ser Ser Leu Cys
            500                 505                 510         
Gly Tyr Pro Gln Leu Val Thr Gln Val His Val Leu Gly Ala Ala Gly
        515                 520                 525             
Leu Lys Asp Ser Pro Thr Gly Ala Asn Ser Tyr Val Ile Ile Lys Cys
    530                 535                 540                 
Glu Gly Asp Lys Val Arg Ser Ala Val Gln Lys Gly Thr Ser Thr Pro
545                 550                 555                 560 
Glu Tyr Asn Val Lys Gly Ile Phe Tyr Arg Lys Lys Leu Ser Gln Pro
                565                 570                 575     
Ile Thr Val Gln Val Trp Asn His Arg Val Leu Lys Asp Glu Phe Leu
            580                 585                 590         
Gly Gln Val His Leu Lys Ala Asp Pro Asp Asn Leu Gln Ala Leu His
        595                 600                 605             
Thr Leu His Leu Arg Asp Arg Asn Ser Arg Gln Pro Ser Asn Leu Pro
    610                 615                 620                 
Gly Thr Val Ala Val His Ile Leu Ser Ser Thr Ser Leu Met Ala Val
625                 630                 635                 640 


<210> 2194
<211> 272
<212> PRT
<213> Homo sapiens

<400> 2194
Met Lys Met Met His Met Ala His Cys Val Thr Leu Val Gln Leu Ser
 1               5                  10                  15      
Ile Ser Cys Asp His Leu Ile Asp Lys Asp Ile Gly Ser Lys Ser Asp
            20                  25                  30          
Pro Leu Cys Val Leu Leu Gln Asp Val Gly Gly Gly Ser Trp Ala Glu
        35                  40                  45              
Leu Gly Arg Thr Glu Arg Val Arg Asn Cys Ser Ser Pro Glu Phe Ser
    50                  55                  60                  
Lys Thr Leu Gln Leu Glu Tyr Arg Phe Glu Thr Val Gln Lys Leu Arg
65                  70                  75                  80  
Phe Gly Ile Tyr Asp Ile Asp Asn Lys Thr Pro Glu Leu Arg Asp Asp
                85                  90                  95      
Asp Phe Leu Gly Gly Ala Glu Cys Ser Leu Gly Gln Ile Val Ser Ser
            100                 105                 110         
Gln Val Leu Thr Leu Pro Leu Met Leu Lys Pro Gly Lys Pro Ala Gly
        115                 120                 125             
Arg Gly Thr Ile Thr Val Ser Ala Gln Glu Leu Lys Asp Asn Arg Val
    130                 135                 140                 
Val Thr Met Glu Val Glu Ala Arg Asn Leu Asp Lys Lys Asp Phe Leu
145                 150                 155                 160 
Gly Lys Ser Asp Pro Phe Leu Glu Phe Phe Arg Gln Gly Asp Gly Lys
                165                 170                 175     
Trp His Leu Val Tyr Arg Ser Glu Val Ile Lys Asn Asn Leu Asn Pro
            180                 185                 190         
Thr Trp Lys Arg Phe Ser Val Pro Val Gln His Phe Cys Gly Gly Asn
        195                 200                 205             
Pro Ser Thr Pro Ile Gln Val Gln Cys Ser Asp Tyr Asp Ser Asp Gly
    210                 215                 220                 
Ser His Asp Leu Ile Gly Thr Phe His Thr Ser Leu Ala Gln Leu Gln
225                 230                 235                 240 
Ala Val Pro Leu Ser Leu Asn Ala Ser Thr Leu Arg Ser Ser Arg Lys
                245                 250                 255     
Arg Lys Ala Thr Arg Thr Leu Glu Leu Ser Val Ser Arg Phe Val Gly
            260                 265                 270         


<210> 2195
<211> 238
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 210, 217, 223
<223> Xaa = Any Amino Acid

<400> 2195
Met Phe Gly Val Thr Leu Trp Glu Met Phe Ser Gly Gly Glu Glu Pro
 1               5                  10                  15      
Trp Ala Gly Val Pro Pro Tyr Leu Ile Leu Gln Arg Leu Glu Asp Arg
            20                  25                  30          
Ala Arg Leu Pro Arg Pro Pro Leu Cys Ser Arg Ala Leu Tyr Ser Leu
        35                  40                  45              
Ala Leu Arg Cys Trp Ala Pro His Pro Ser Asp Arg Pro Ser Phe Ser
    50                  55                  60                  
His Leu Glu Gly Leu Leu Gln Glu Ala Gly Pro Ser Glu Ala Cys Cys
65                  70                  75                  80  
Val Arg Asp Val Thr Glu Pro Gly Ala Leu Arg Met Glu Thr Gly Asp
                85                  90                  95      
Pro Ile Thr Val Ile Glu Gly Ser Ser Ser Phe His Ser Pro Asp Ser
            100                 105                 110         
Thr Ile Trp Lys Gly Gln Asn Gly Arg Thr Phe Lys Val Gly Ser Phe
        115                 120                 125             
Pro Ala Ser Ala Val Thr Leu Ala Asp Ala Gly Gly Leu Pro Ala Thr
    130                 135                 140                 
Arg Pro Val His Arg Gly His Pro Cys Pro Gly Arg Ser Thr Pro Arg
145                 150                 155                 160 
Lys His Arg Trp Arg Gln Lys Glu Gly Lys Ser Leu Gly Cys Ala Pro
                165                 170                 175     
Ser Thr Gly Pro Glu Glu Glu His Ala Pro Gly Glu Asp Glu Arg His
            180                 185                 190         
Phe Gln Glu Ser Gly Val Ser Ser Val Pro Arg Ser Ser Ser His Arg
        195                 200                 205             
Gly Xaa Val Gln Ala Pro Leu Lys Xaa Arg Gln Ala Arg Ala Xaa Ala
    210                 215                 220                 
Pro Gly Thr Ser Arg Pro Ala Ser Thr Pro Thr Phe Ile Leu
225                 230                 235             


<210> 2196
<211> 1239
<212> PRT
<213> Homo sapiens

<400> 2196
Met Pro Lys Val Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Gly
 1               5                  10                  15      
Glu Gly Pro Asp Val Asp Val Asn Leu Pro Lys Ala Asp Ile Asp Val
            20                  25                  30          
Ser Gly Pro Lys Val Asp Val Asp Val Pro Asp Val Asn Ile Glu Gly
        35                  40                  45              
Pro Asp Ala Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met Ser
    50                  55                  60                  
Ile Lys Ala Pro Lys Ile Ser Met Pro Asp Ile Asp Leu Asn Leu Lys
65                  70                  75                  80  
Gly Pro Lys Val Lys Gly Asp Val Asp Val Thr Leu Pro Lys Val Glu
                85                  90                  95      
Gly Asp Leu Lys Gly Pro Glu Ala Asp Ile Lys Gly Pro Lys Val Asp
            100                 105                 110         
Ile Asn Thr Pro Asp Val Asp Val His Gly Pro Asp Trp His Leu Lys
        115                 120                 125             
Met Pro Lys Val Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Gly
    130                 135                 140                 
Glu Gly Pro Asp Val Asp Val Ser Leu Pro Lys Ala Asp Ile Asp Val
145                 150                 155                 160 
Ser Gly Pro Lys Val Asp Val Asp Ile Pro Asp Val Asn Ile Glu Gly
                165                 170                 175     
Pro Asp Ala Lys Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Ile Asn
            180                 185                 190         
Ile Lys Ala Pro Lys Ile Ser Ile Pro Asp Val Asp Leu Asp Leu Lys
        195                 200                 205             
Gly Pro Lys Val Lys Gly Asp Phe Asp Val Ser Val Pro Lys Val Glu
    210                 215                 220                 
Gly Thr Leu Lys Gly Pro Glu Val Asp Leu Lys Gly Pro Arg Leu Asp
225                 230                 235                 240 
Phe Glu Gly Pro Asp Ala Lys Leu Ser Gly Pro Ser Leu Lys Met Pro
                245                 250                 255     
Ser Leu Glu Ile Ser Ala Pro Lys Val Thr Ala Pro Asp Val Asp Leu
            260                 265                 270         
His Leu Lys Ala Pro Lys Ile Gly Phe Ser Gly Pro Lys Leu Glu Gly
        275                 280                 285             
Gly Glu Val Asp Leu Lys Gly Pro Lys Val Glu Ala Pro Ser Leu Asp
    290                 295                 300                 
Val His Met Asp Ser Pro Asp Ile Asn Ile Glu Gly Pro Asp Val Lys
305                 310                 315                 320 
Ile Pro Lys Phe Lys Lys Pro Lys Phe Gly Phe Gly Ala Lys Ser Pro
                325                 330                 335     
Lys Ala Asp Ile Lys Ser Pro Ser Leu Asp Val Thr Val Pro Glu Ala
            340                 345                 350         
Glu Leu Asn Leu Glu Thr Pro Glu Ile Ser Val Gly Gly Lys Gly Lys
        355                 360                 365             
Lys Ser Lys Phe Lys Met Pro Lys Ile His Met Ser Gly Pro Lys Ile
    370                 375                 380                 
Lys Ala Lys Lys Gln Gly Phe Asp Leu Asn Val Pro Gly Gly Glu Ile
385                 390                 395                 400 
Asp Ala Ser Leu Lys Ala Pro Asp Val Asp Val Asn Ile Ala Gly Pro
                405                 410                 415     
Asp Ala Ala Leu Lys Val Asp Val Lys Ser Pro Lys Thr Lys Lys Thr
            420                 425                 430         
Met Phe Gly Lys Met Tyr Phe Pro Asp Val Glu Phe Asp Ile Lys Ser
        435                 440                 445             
Pro Lys Phe Lys Ala Glu Ala Pro Leu Pro Ser Pro Lys Leu Glu Gly
    450                 455                 460                 
Glu Leu Gln Ala Pro Asp Leu Glu Leu Ser Leu Pro Ala Ile His Val
465                 470                 475                 480 
Glu Gly Leu Asp Ile Lys Ala Lys Ala Pro Lys Val Lys Met Pro Asp
                485                 490                 495     
Val Asp Ile Ser Val Pro Lys Ile Glu Gly Asp Leu Lys Gly Pro Lys
            500                 505                 510         
Val Gln Ala Asn Leu Gly Ala Pro Asp Ile Asn Ile Glu Gly Leu Asp
        515                 520                 525             
Ala Lys Val Lys Thr Pro Ser Phe Gly Ile Ser Ala Pro Gln Val Ser
    530                 535                 540                 
Ile Pro Asp Val Asn Val Asn Leu Lys Gly Pro Lys Ile Lys Gly Asp
545                 550                 555                 560 
Val Pro Ser Val Gly Leu Glu Gly Pro Asp Val Asp Leu Gln Gly Pro
                565                 570                 575     
Glu Ala Lys Ile Lys Phe Pro Lys Phe Ser Met Pro Lys Ile Gly Ile
            580                 585                 590         
Pro Gly Val Lys Met Glu Gly Gly Gly Ala Glu Val His Ala Gln Leu
        595                 600                 605             
Pro Ser Leu Glu Gly Asp Leu Arg Gly Pro Asp Val Lys Leu Glu Gly
    610                 615                 620                 
Pro Asp Val Ser Leu Lys Gly Pro Gly Val Asp Leu Pro Ser Val Asn
625                 630                 635                 640 
Leu Ser Met Pro Lys Val Ser Gly Pro Asp Leu Asp Leu Asn Leu Lys
                645                 650                 655     
Gly Pro Ser Leu Lys Gly Asp Leu Asp Ala Ser Val Pro Ser Met Lys
            660                 665                 670         
Val His Ala Pro Gly Leu Asn Leu Ser Gly Val Gly Gly Lys Met Gln
        675                 680                 685             
Val Gly Gly Asp Gly Val Lys Val Pro Gly Ile Asp Ala Thr Thr Lys
    690                 695                 700                 
Leu Asn Val Gly Ala Pro Asp Val Thr Leu Arg Gly Pro Ser Leu Gln
705                 710                 715                 720 
Gly Asp Leu Ala Val Ser Gly Asp Ile Lys Cys Pro Lys Val Ser Val
                725                 730                 735     
Gly Ala Pro Asp Leu Ser Leu Glu Ala Ser Glu Gly Ser Ile Lys Leu
            740                 745                 750         
Pro Lys Met Lys Leu Pro Gln Phe Gly Ile Ser Thr Pro Gly Ser Asp
        755                 760                 765             
Leu His Val Asn Ala Lys Gly Pro Gln Val Ser Gly Glu Leu Lys Gly
    770                 775                 780                 
Pro Gly Val Asp Val Asn Leu Lys Gly Pro Arg Ile Ser Ala Pro Asn
785                 790                 795                 800 
Val Asp Phe Asn Leu Glu Gly Pro Lys Val Lys Gly Ser Leu Gly Ala
                805                 810                 815     
Thr Gly Glu Ile Lys Gly Pro Thr Val Gly Gly Gly Leu Pro Gly Ile
            820                 825                 830         
Gly Val Gln Gly Leu Glu Gly Asn Leu Gln Met Pro Gly Ile Lys Ser
        835                 840                 845             
Ser Gly Cys Asp Val Asn Leu Pro Gly Val Asn Val Lys Leu Pro Thr
    850                 855                 860                 
Gly Gln Ile Ser Gly Pro Glu Ile Lys Gly Gly Leu Lys Gly Ser Glu
865                 870                 875                 880 
Val Gly Phe His Gly Ala Ala Pro Asp Ile Ser Val Lys Gly Pro Ala
                885                 890                 895     
Phe Asn Met Ala Ser Pro Glu Ser Asp Phe Gly Ile Asn Leu Lys Gly
            900                 905                 910         
Pro Lys Ile Lys Gly Gly Ala Asp Val Ser Gly Gly Val Ser Ala Pro
        915                 920                 925             
Asp Ile Ser Leu Gly Glu Gly His Leu Ser Val Lys Gly Ser Gly Gly
    930                 935                 940                 
Glu Trp Lys Gly Pro Gln Val Ser Ser Ala Leu Asn Leu Asp Thr Ser
945                 950                 955                 960 
Lys Phe Ala Gly Gly Leu His Phe Ser Gly Pro Lys Val Glu Gly Gly
                965                 970                 975     
Val Lys Gly Gly Gln Ile Gly Leu Gln Ala Pro Gly Leu Ser Val Ser
            980                 985                 990         
Gly Pro Gln Gly His Leu Glu Ser Gly Ser Gly Lys Val Thr Phe Pro
        995                 1000                1005            
Lys Met Lys Ile Pro Lys Phe Thr Phe Ser Gly Arg Glu Leu Val Gly
    1010                1015                1020                
Arg Glu Met Gly Val Asp Val His Phe Pro Lys Ala Glu Ala Ser Ile
1025                1030                1035                1040
Gln Ala Gly Ala Gly Asp Gly Glu Trp Glu Glu Ser Glu Val Lys Leu
                1045                1050                1055    
Lys Lys Ser Lys Ile Lys Met Pro Lys Phe Asn Phe Ser Lys Pro Lys
            1060                1065                1070        
Gly Lys Gly Gly Val Thr Gly Ser Pro Glu Ala Ser Ile Ser Gly Ser
        1075                1080                1085            
Lys Gly Asp Leu Lys Ser Ser Lys Ala Ser Leu Gly Ser Leu Glu Gly
    1090                1095                1100                
Glu Ala Glu Ala Glu Ala Ser Ser Pro Lys Gly Lys Phe Ser Leu Phe
1105                1110                1115                1120
Lys Ser Lys Lys Pro Arg His Arg Ser Asn Ser Phe Ser Asp Glu Arg
                1125                1130                1135    
Glu Phe Ser Gly Pro Ser Thr Pro Thr Gly Thr Leu Glu Phe Glu Gly
            1140                1145                1150        
Gly Glu Val Ser Leu Glu Gly Gly Lys Val Lys Gly Lys His Gly Lys
        1155                1160                1165            
Leu Lys Phe Gly Thr Phe Gly Gly Leu Gly Ser Lys Ser Lys Gly His
    1170                1175                1180                
Tyr Glu Val Thr Gly Ser Asp Asp Glu Thr Gly Lys Leu Gln Gly Ser
1185                1190                1195                1200
Gly Val Ser Leu Ala Ser Lys Lys Ser Arg Leu Ser Ser Ser Ser Ser
                1205                1210                1215    
Asn Asp Ser Gly Asn Lys Val Gly Ile Gln Leu Pro Glu Val Glu Leu
            1220                1225                1230        
Ser Val Ser Thr Lys Lys Glu
        1235                


<210> 2197
<211> 707
<212> PRT
<213> Homo sapiens

<400> 2197
Met Asp Pro Gly Trp Gly Gln Arg Asp Val Gly Trp Ala Ala Leu Leu
 1               5                  10                  15      
Ile Leu Phe Ala Ala Ser Leu Leu Thr Val Phe Ala Trp Leu Leu Gln
            20                  25                  30          
Tyr Ala Arg Gly Leu Trp Leu Ala Arg Ala Arg Gly Asp Arg Gly Pro
        35                  40                  45              
Gly Pro Ala Leu Ala Gly Glu Pro Ala Gly Ser Leu Arg Glu Leu Gly
    50                  55                  60                  
Val Trp Arg Ser Leu Leu Arg Leu Arg Ala Thr Arg Ala Gly Ala Ala
65                  70                  75                  80  
Glu Glu Pro Gly Val Arg Gly Leu Leu Ala Ser Leu Phe Ala Phe Asn
                85                  90                  95      
Ser Phe Arg Glu Asn Trp Gln Arg Ala Trp Val Arg Ala Leu Asn Glu
            100                 105                 110         
Gln Ala Cys Arg Asn Gly Ser Ser Ile Gln Ile Ala Phe Glu Glu Val
        115                 120                 125             
Pro Gln Leu Pro Pro Arg Ala Ser Ile Ser His Val Thr Cys Val Asp
    130                 135                 140                 
Gln Ser Glu His Thr Met Val Leu Arg Cys Gln Leu Ser Ala Glu Glu
145                 150                 155                 160 
Val Arg Phe Pro Val Ser Val Thr Gln Gln Ser Pro Ala Ala Val Ser
                165                 170                 175     
Met Glu Thr Tyr His Val Thr Leu Thr Leu Pro Pro Thr Gln Leu Glu
            180                 185                 190         
Val Asn Leu Glu Glu Ile Pro Gly Glu Gly Leu Leu Ile Ser Trp Ala
        195                 200                 205             
Phe Thr Asp Arg Pro Asp Leu Ser Leu Thr Val Leu Pro Lys Leu Gln
    210                 215                 220                 
Ala Arg Glu Arg Gly Glu Glu Gln Val Glu Leu Ser Thr Ile Glu Glu
225                 230                 235                 240 
Leu Ile Lys Asp Ala Ile Val Ser Thr Gln Pro Ala Met Met Val Asn
                245                 250                 255     
Leu Arg Ala Cys Ser Ala Pro Gly Gly Leu Val Pro Ser Glu Lys Pro
            260                 265                 270         
Pro Met Met Pro Gln Ala Gln Pro Ala Ile Pro Arg Pro Asn Arg Leu
        275                 280                 285             
Phe Leu Arg Gln Leu Arg Ala Ser His Leu Gly Asn Glu Leu Glu Gly
    290                 295                 300                 
Thr Glu Glu Leu Cys Cys Val Ala Glu Leu Asp Asn Pro Met Gln Gln
305                 310                 315                 320 
Lys Trp Thr Lys Pro Ala Arg Ala Gly Ser Glu Val Glu Trp Thr Glu
                325                 330                 335     
Asp Leu Ala Leu Asp Leu Gly Pro Gln Ser Arg Glu Leu Thr Leu Lys
            340                 345                 350         
Val Leu Arg Ser Ser Ser Cys Gly Asp Thr Glu Leu Leu Gly Gln Ala
        355                 360                 365             
Thr Leu Pro Val Gly Ser Pro Ser Arg Pro Leu Ser Arg Arg Gln Leu
    370                 375                 380                 
Cys Pro Leu Thr Pro Gly Pro Gly Lys Ala Leu Gly Pro Ala Ala Thr
385                 390                 395                 400 
Met Ala Val Glu Leu His Tyr Glu Glu Gly Ser Pro Arg Asn Leu Gly
                405                 410                 415     
Thr Pro Thr Ser Ser Thr Pro Arg Pro Ser Ile Thr Pro Thr Lys Lys
            420                 425                 430         
Ile Glu Leu Asp Arg Thr Ile Met Pro Asp Gly Thr Ile Val Thr Thr
        435                 440                 445             
Val Thr Thr Val Gln Ser Arg Pro Arg Ile Asp Gly Lys Leu Asp Ser
    450                 455                 460                 
Pro Ser Arg Ser Pro Ser Lys Val Glu Val Thr Glu Lys Thr Thr Thr
465                 470                 475                 480 
Val Leu Ser Glu Ser Ser Gly Pro Ser Asn Thr Ser His Ser Ser Ser
                485                 490                 495     
Pro Gly Asp Ser His Leu Ser Asn Gly Leu Asp Pro Val Ala Glu Thr
            500                 505                 510         
Ala Ile Arg Gln Leu Thr Glu Pro Ser Gly Arg Val Ala Lys Lys Thr
        515                 520                 525             
Pro Thr Lys Arg Ser Thr Leu Ile Ile Ser Gly Val Ser Lys Val Pro
    530                 535                 540                 
Ile Ala Gln Asp Glu Leu Ala Leu Ser Leu Gly Tyr Ala Ala Ser Leu
545                 550                 555                 560 
Glu Ala Ser Val Gln Asp Asp Ala Gly Thr Ser Gly Gly Pro Ser Ser
                565                 570                 575     
Pro Pro Ser Asp Pro Pro Ala Met Ser Pro Gly Pro Leu Asp Ala Leu
            580                 585                 590         
Ser Ser Pro Thr Ser Val Gln Glu Ala Asp Glu Thr Thr Arg Ser Asp
        595                 600                 605             
Ile Ser Glu Arg Pro Ser Val Asp Asp Ile Glu Ser Glu Thr Gly Ser
    610                 615                 620                 
Thr Gly Ala Leu Glu Thr Arg Ser Leu Lys Asp His Lys Val Ser Phe
625                 630                 635                 640 
Leu Arg Ser Gly Thr Lys Leu Ile Phe Arg Arg Met Pro Arg His Asn
                645                 650                 655     
Glu Ser Gly Leu Ser Gln Ser His Asp Asp Leu Ser Asn Ala Thr Ala
            660                 665                 670         
Thr Pro Ser Val Arg Lys Lys Ala Gly Ser Phe Ser Arg Arg Leu Ile
        675                 680                 685             
Lys Arg Phe Ser Phe Lys Ser Lys Pro Lys Ala Asn Gly Asn Pro Ser
    690                 695                 700                 
Pro Pro Leu
705         


<210> 2198
<211> 148
<212> PRT
<213> Homo sapiens

<400> 2198
Met Ala Lys Asp Ile Leu Gly Glu Ala Gly Leu His Phe Asp Glu Leu
 1               5                  10                  15      
Asn Lys Leu Arg Val Leu Asp Pro Glu Val Thr Gln Gln Thr Ile Glu
            20                  25                  30          
Leu Lys Glu Glu Cys Lys Asp Phe Val Asp Lys Ile Gly Gln Phe Gln
        35                  40                  45              
Lys Ile Val Gly Gly Leu Ile Glu Leu Val Asp Gln Leu Ala Lys Glu
    50                  55                  60                  
Ala Glu Asn Glu Lys Met Lys Ser Leu Ala Val Ser Pro Arg Leu Glu
65                  70                  75                  80  
Cys Thr Gly Ala Ile Ser Ala His Cys Lys Leu Cys Leu Ser Asp Ser
                85                  90                  95      
Ser Asp Ser Pro Thr Ser Pro Ser Arg Val Gly Gly Thr Thr Gly His
            100                 105                 110         
Arg Cys Ser Glu Leu Ala Gln Ile Tyr Ser Lys Ala Glu Arg Ser Ser
        115                 120                 125             
Thr Ala Ala Thr Ser Ser Pro Asn Ser Arg Lys Glu Asn Ala Ala Arg
    130                 135                 140                 
Lys Val Ser Gly
145             


<210> 2199
<211> 103
<212> PRT
<213> Homo sapiens

<400> 2199
Met Ala Gln Phe Val Arg Asn Leu Val Glu Lys Thr Pro Ala Leu Val
 1               5                  10                  15      
Asn Ala Ala Val Thr Tyr Ser Lys Pro Arg Leu Ala Thr Phe Trp Tyr
            20                  25                  30          
Tyr Ala Lys Val Glu Leu Val Pro Pro Thr Pro Ala Glu Ile Pro Arg
        35                  40                  45              
Ala Ile Gln Ser Leu Lys Lys Ile Val Asn Ser Ala Gln Thr Gly Ser
    50                  55                  60                  
Phe Lys Gln Leu Thr Val Lys Glu Ala Val Leu Asn Gly Leu Val Ala
65                  70                  75                  80  
Thr Glu Val Leu Met Trp Phe Tyr Val Gly Glu Ile Ile Gly Lys Arg
                85                  90                  95      
Gly Ile Ile Gly Tyr Asp Val
            100             


<210> 2200
<211> 1744
<212> PRT
<213> Homo sapiens

<400> 2200
Met Val Ile Asp Pro Leu His Val Thr Leu Thr Pro Lys Lys Leu Lys
 1               5                  10                  15      
Thr Gly Ile Gly Ser Thr Val Ile Leu Ser Cys Ala Leu Thr Gly Ser
            20                  25                  30          
Pro Glu Phe Thr Ile Arg Trp Tyr Arg Asn Thr Glu Leu Val Leu Pro
        35                  40                  45              
Asp Glu Ala Ile Ser Ile Arg Gly Leu Ser Asn Glu Thr Leu Leu Ile
    50                  55                  60                  
Thr Ser Ala Gln Lys Ser His Ser Gly Ala Tyr Gln Cys Phe Ala Thr
65                  70                  75                  80  
Arg Lys Ala Gln Thr Ala Gln Asp Phe Ala Ile Ile Ala Leu Glu Asp
                85                  90                  95      
Gly Thr Pro Arg Ile Val Ser Ser Phe Ser Glu Lys Val Val Asn Pro
            100                 105                 110         
Gly Glu Gln Phe Ser Leu Met Cys Ala Ala Lys Gly Ala Pro Pro Pro
        115                 120                 125             
Thr Val Thr Trp Ala Leu Asp Asp Glu Pro Ile Val Arg Asp Gly Ser
    130                 135                 140                 
His Arg Thr Asn Gln Tyr Thr Met Ser Asp Gly Thr Thr Ile Ser His
145                 150                 155                 160 
Met Asn Val Thr Gly Pro Gln Ile Arg Asp Gly Gly Val Tyr Arg Cys
                165                 170                 175     
Thr Ala Arg Asn Leu Val Gly Ser Ala Glu Tyr Gln Ala Arg Ile Asn
            180                 185                 190         
Val Arg Gly Pro Pro Ser Ile Arg Ala Met Arg Asn Ile Thr Ala Val
        195                 200                 205             
Ala Gly Arg Asp Thr Leu Ile Asn Cys Arg Val Ile Gly Tyr Pro Tyr
    210                 215                 220                 
Tyr Ser Ile Lys Trp Tyr Lys Asp Ala Leu Leu Leu Pro Asp Asn His
225                 230                 235                 240 
Arg Gln Val Val Phe Glu Asn Gly Thr Leu Lys Leu Thr Asp Val Gln
                245                 250                 255     
Lys Gly Met Asp Glu Gly Glu Tyr Leu Cys Ser Val Leu Ile Gln Pro
            260                 265                 270         
Gln Leu Ser Ile Ser Gln Ser Val His Val Ala Val Lys Val Pro Pro
        275                 280                 285             
Leu Ile Gln Pro Phe Glu Phe Pro Pro Ala Ser Ile Gly Gln Leu Leu
    290                 295                 300                 
Tyr Ile Pro Cys Val Val Ser Ser Gly Asp Met Pro Ile Arg Ile Thr
305                 310                 315                 320 
Trp Arg Lys Asp Gly Gln Val Ile Ile Ser Gly Ser Gly Val Thr Ile
                325                 330                 335     
Glu Ser Lys Glu Phe Met Ser Ser Leu Gln Ile Ser Ser Val Ser Leu
            340                 345                 350         
Lys His Asn Gly Asn Tyr Thr Cys Ile Ala Ser Asn Ala Ala Ala Thr
        355                 360                 365             
Val Ser Arg Glu Arg Gln Leu Ile Val Arg Val Pro Pro Arg Phe Val
    370                 375                 380                 
Val Gln Pro Asn Asn Gln Asp Gly Ile Tyr Gly Lys Ala Gly Val Leu
385                 390                 395                 400 
Asn Cys Ser Val Asp Gly Tyr Pro Pro Pro Lys Val Met Trp Lys His
                405                 410                 415     
Ala Lys Gly Ser Gly Asn Pro Gln Gln Tyr His Pro Val Pro Leu Thr
            420                 425                 430         
Gly Arg Ile Gln Ile Leu Pro Asn Ser Ser Leu Leu Ile Arg His Val
        435                 440                 445             
Leu Glu Glu Asp Ile Gly Tyr Tyr Leu Cys Gln Ala Ser Asn Gly Val
    450                 455                 460                 
Gly Thr Asp Ile Ser Lys Ser Met Phe Leu Thr Val Lys Ile Pro Ala
465                 470                 475                 480 
Met Ile Thr Ser His Pro Asn Thr Thr Ile Ala Ile Lys Gly His Ala
                485                 490                 495     
Lys Glu Leu Asn Cys Thr Ala Arg Gly Glu Arg Pro Ile Ile Ile Arg
            500                 505                 510         
Trp Glu Lys Gly Asp Thr Val Ile Asp Pro Asp Arg Val Met Arg Tyr
        515                 520                 525             
Ala Ile Ala Thr Lys Asp Asn Gly Asp Glu Val Val Ser Thr Leu Lys
    530                 535                 540                 
Leu Lys Pro Ala Asp Arg Gly Asp Ser Val Phe Phe Ser Cys His Ala
545                 550                 555                 560 
Ile Asn Ser Tyr Gly Glu Asp Arg Gly Leu Ile Gln Leu Thr Val Gln
                565                 570                 575     
Glu Pro Pro Asp Pro Pro Glu Leu Glu Ile Arg Glu Val Lys Ala Arg
            580                 585                 590         
Ser Met Asn Leu Arg Trp Thr Gln Arg Phe Asp Gly Asn Ser Ile Ile
        595                 600                 605             
Thr Gly Phe Asp Ile Glu Tyr Lys Asn Lys Ser Asp Ser Trp Asp Phe
    610                 615                 620                 
Lys Gln Ser Thr Arg Asn Ile Ser Pro Thr Ile Asn Gln Ala Asn Ile
625                 630                 635                 640 
Val Asp Leu His Pro Ala Ser Val Tyr Ser Ile Arg Met Tyr Ser Phe
                645                 650                 655     
Asn Lys Ile Gly Arg Ser Glu Pro Ser Lys Glu Leu Thr Ile Ser Thr
            660                 665                 670         
Glu Glu Ala Ala Pro Asp Gly Pro Pro Met Asp Val Thr Leu Gln Pro
        675                 680                 685             
Val Thr Ser Gln Ser Ile Gln Val Thr Trp Lys Ala Pro Lys Lys Glu
    690                 695                 700                 
Leu Gln Asn Gly Val Ile Arg Gly Tyr Gln Ile Gly Tyr Arg Glu Asn
705                 710                 715                 720 
Ser Pro Gly Ser Asn Gly Gln Tyr Ser Ile Val Glu Met Lys Ala Thr
                725                 730                 735     
Gly Asp Ser Glu Val Tyr Thr Leu Asp Asn Leu Lys Lys Phe Ala Gln
            740                 745                 750         
Tyr Gly Val Val Val Gln Ala Phe Asn Arg Ala Gly Thr Gly Pro Ser
        755                 760                 765             
Ser Ser Glu Ile Asn Ala Thr Thr Leu Glu Asp Val Pro Ser Gln Pro
    770                 775                 780                 
Pro Glu Asn Val Arg Ala Leu Ser Ile Thr Ser Asp Val Ala Val Ile
785                 790                 795                 800 
Ser Trp Ser Glu Pro Pro Arg Ser Thr Leu Asn Gly Val Leu Lys Gly
                805                 810                 815     
Tyr Arg Val Ile Phe Trp Ser Leu Tyr Val Asp Gly Glu Trp Gly Glu
            820                 825                 830         
Met Gln Asn Ile Thr Thr Thr Arg Glu Arg Val Glu Leu Arg Gly Met
        835                 840                 845             
Glu Lys Phe Thr Asn Tyr Ser Val Gln Val Leu Ala Tyr Thr Gln Ala
    850                 855                 860                 
Gly Asp Gly Val Arg Ser Ser Val Leu Tyr Ile Gln Thr Lys Glu Asp
865                 870                 875                 880 
Val Pro Gly Pro Pro Ala Gly Ile Lys Ala Val Pro Ser Ser Ala Ser
                885                 890                 895     
Ser Val Val Val Ser Trp Leu Pro Pro Thr Lys Pro Asn Gly Val Ile
            900                 905                 910         
Arg Lys Tyr Thr Ile Phe Cys Ser Ser Pro Gly Ser Gly Gln Pro Ala
        915                 920                 925             
Pro Ser Glu Tyr Glu Thr Ser Pro Glu Gln Leu Phe Tyr Arg Ile Ala
    930                 935                 940                 
His Leu Asn Arg Gly Gln Gln Tyr Leu Leu Trp Val Ala Ala Val Thr
945                 950                 955                 960 
Ser Ala Gly Arg Gly Asn Ser Ser Glu Lys Val Thr Ile Glu Pro Ala
                965                 970                 975     
Gly Lys Ala Pro Ala Lys Ile Ile Ser Phe Gly Gly Thr Val Thr Thr
            980                 985                 990         
Pro Trp Met Lys Asp Val Arg Leu Pro Cys Asn Ser Val Gly Asp Pro
        995                 1000                1005            
Ala Pro Ala Val Lys Trp Thr Lys Asp Ser Glu Asp Ser Ala Ile Pro
    1010                1015                1020                
Val Ser Met Asp Gly His Arg Leu Ile His Thr Asn Gly Thr Leu Leu
1025                1030                1035                1040
Leu Arg Ala Val Lys Ala Glu Asp Ser Gly Tyr Tyr Thr Cys Thr Ala
                1045                1050                1055    
Thr Asn Thr Gly Gly Phe Asp Thr Ile Ile Val Asn Leu Leu Val Gln
            1060                1065                1070        
Val Pro Pro Asp Gln Pro Arg Leu Thr Val Ser Lys Thr Ser Ala Ser
        1075                1080                1085            
Ser Ile Thr Leu Thr Trp Ile Pro Gly Asp Asn Gly Gly Ser Ser Ile
    1090                1095                1100                
Arg Gly Phe Val Leu Gln Tyr Ser Val Asp Asn Ser Glu Glu Trp Lys
1105                1110                1115                1120
Asp Val Phe Ile Ser Ser Ser Glu Arg Ser Phe Lys Leu Asp Ser Leu
                1125                1130                1135    
Lys Cys Gly Thr Trp Tyr Lys Val Lys Leu Ala Ala Lys Asn Ser Val
            1140                1145                1150        
Gly Ser Gly Arg Ile Ser Glu Ile Ile Glu Ala Lys Thr His Gly Arg
        1155                1160                1165            
Glu Pro Ser Phe Ser Lys Asp Gln His Leu Phe Thr His Ile Asn Ser
    1170                1175                1180                
Thr His Ala Arg Leu Asn Leu Gln Gly Trp Asn Asn Gly Gly Cys Pro
1185                1190                1195                1200
Ile Thr Ala Ile Val Leu Glu Tyr Arg Pro Lys Gly Thr Trp Ala Trp
                1205                1210                1215    
Gln Gly Leu Arg Ala Asn Ser Ser Gly Glu Val Phe Leu Thr Glu Leu
            1220                1225                1230        
Arg Glu Ala Thr Trp Tyr Glu Leu Arg Met Arg Ala Cys Asn Ser Ala
        1235                1240                1245            
Gly Cys Gly Asn Glu Thr Ala Gln Phe Ala Thr Leu Asp Tyr Asp Gly
    1250                1255                1260                
Ser Thr Ile Pro Pro Ile Lys Ser Ala Gln Gly Glu Gly Asp Asp Val
1265                1270                1275                1280
Lys Lys Leu Phe Thr Ile Gly Cys Pro Val Ile Leu Ala Thr Leu Gly
                1285                1290                1295    
Val Ala Leu Leu Phe Ile Val Arg Lys Lys Arg Lys Glu Lys Arg Leu
            1300                1305                1310        
Lys Arg Leu Arg Asp Ala Lys Ser Leu Ala Glu Met Leu Ile Ser Lys
        1315                1320                1325            
Asn Asn Arg Ser Phe Asp Thr Pro Val Lys Gly Pro Pro Gln Gly Pro
    1330                1335                1340                
Arg Leu His Ile Asp Ile Pro Arg Val Gln Leu Leu Ile Glu Asp Lys
1345                1350                1355                1360
Glu Gly Ile Lys Gln Leu Gly Asp Asp Lys Ala Thr Ile Pro Val Thr
                1365                1370                1375    
Asp Ala Glu Phe Ser Gln Ala Val Asn Pro Gln Ser Phe Cys Thr Gly
            1380                1385                1390        
Val Ser Leu His His Pro Thr Leu Ile Gln Ser Thr Gly Pro Leu Ile
        1395                1400                1405            
Asp Met Ser Asp Ile Arg Pro Gly Thr Asn Pro Val Ser Arg Lys Asn
    1410                1415                1420                
Val Lys Ser Ala His Ser Thr Arg Asn Arg Tyr Ser Ser Gln Trp Thr
1425                1430                1435                1440
Leu Thr Lys Cys Gln Ala Ser Thr Pro Ala Arg Thr Leu Thr Ser Asp
                1445                1450                1455    
Trp Arg Thr Val Gly Ser Gln His Gly Val Thr Val Thr Glu Ser Asp
            1460                1465                1470        
Ser Tyr Ser Ala Ser Leu Ser Gln Asp Thr Asp Lys Gly Arg Asn Ser
        1475                1480                1485            
Met Val Ser Thr Glu Ser Ala Ser Ser Thr Tyr Glu Glu Leu Ala Arg
    1490                1495                1500                
Ala Tyr Glu His Ala Lys Leu Glu Glu Gln Leu Gln His Ala Lys Phe
1505                1510                1515                1520
Glu Ile Thr Glu Cys Phe Ile Ser Asp Ser Ser Ser Asp Gln Met Thr
                1525                1530                1535    
Thr Gly Thr Asn Glu Asn Ala Asp Ser Met Thr Ser Met Ser Thr Pro
            1540                1545                1550        
Ser Glu Pro Gly Ile Cys Arg Phe Thr Ala Ser Pro Pro Lys Pro Gln
        1555                1560                1565            
Asp Ala Asp Arg Gly Lys Asn Val Ala Val Pro Ile Pro His Arg Ala
    1570                1575                1580                
Asn Lys Ser Asp Tyr Cys Asn Leu Pro Leu Tyr Ala Lys Ser Glu Ala
1585                1590                1595                1600
Phe Phe Arg Lys Ala Asp Gly Arg Glu Pro Cys Pro Val Val Pro Pro
                1605                1610                1615    
Arg Glu Ala Ser Ile Arg Asn Leu Ala Arg Thr Tyr His Thr Gln Ala
            1620                1625                1630        
Arg His Leu Thr Leu Asp Pro Ala Ser Lys Ser Leu Gly Leu Pro His
        1635                1640                1645            
Pro Gly Ala Pro Ala Ala Ala Ser Thr Ala Thr Leu Pro Gln Arg Thr
    1650                1655                1660                
Leu Ala Met Pro Ala Pro Pro Ala Gly Thr Ala Pro Pro Ala Pro Gly
1665                1670                1675                1680
Pro Thr Pro Ala Glu Pro Pro Thr Ala Pro Ser Ala Ala Pro Pro Ala
                1685                1690                1695    
Pro Ser Thr Glu Pro Pro Arg Ala Gly Gly Pro His Thr Lys Met Gly
            1700                1705                1710        
Gly Ser Arg Asp Ser Leu Leu Glu Met Ser Thr Ser Gly Val Gly Arg
        1715                1720                1725            
Ser Gln Lys Gln Gly Ala Gly Ala Tyr Ser Lys Ser Tyr Thr Leu Val
    1730                1735                1740                


<210> 2201
<211> 158
<212> PRT
<213> Homo sapiens

<400> 2201
Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu
 1               5                  10                  15      
Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln
            20                  25                  30          
Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys
        35                  40                  45              
Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg
    50                  55                  60                  
Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro
65                  70                  75                  80  
Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu
                85                  90                  95      
Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr
            100                 105                 110         
Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp
        115                 120                 125             
Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe
    130                 135                 140                 
Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln
145                 150                 155             


<210> 2202
<211> 397
<212> PRT
<213> Homo sapiens

<400> 2202
Met Gly Gln Ala Gly Cys Lys Gly Leu Cys Leu Ser Leu Phe Asp Tyr
 1               5                  10                  15      
Lys Thr Glu Lys Tyr Val Ile Ala Lys Asn Lys Lys Val Gly Leu Leu
            20                  25                  30          
Tyr Arg Leu Leu Gln Ala Ser Ile Leu Ala Tyr Leu Val Val Trp Val
        35                  40                  45              
Phe Leu Ile Lys Lys Gly Tyr Gln Asp Val Asp Thr Ser Leu Gln Ser
    50                  55                  60                  
Ala Val Ile Thr Lys Val Lys Gly Val Ala Phe Thr Asn Thr Ser Asp
65                  70                  75                  80  
Leu Gly Gln Arg Ile Trp Asp Val Ala Asp Tyr Val Ile Pro Ala Gln
                85                  90                  95      
Asn Glu Gly Ile Pro Asp Gly Ala Cys Ser Lys Asp Ser Asp Cys His
            100                 105                 110         
Ala Gly Glu Ala Val Thr Ala Gly Asn Gly Val Lys Thr Gly Arg Cys
        115                 120                 125             
Leu Arg Arg Glu Asn Leu Ala Arg Gly Thr Cys Glu Ile Phe Ala Trp
    130                 135                 140                 
Cys Pro Leu Glu Thr Ser Ser Arg Pro Glu Glu Pro Phe Leu Lys Glu
145                 150                 155                 160 
Ala Glu Asp Phe Thr Ile Phe Ile Lys Asn His Ile Arg Phe Pro Lys
                165                 170                 175     
Phe Asn Phe Ser Asn Asn Val Met Asp Val Lys Asp Arg Ser Phe Leu
            180                 185                 190         
Lys Ser Cys His Phe Gly Pro Lys Asn His Tyr Cys Pro Ile Phe Arg
        195                 200                 205             
Leu Gly Ser Val Ile Arg Trp Ala Gly Ser Asp Phe Gln Asp Ile Ala
    210                 215                 220                 
Leu Glu Gly Gly Val Ile Gly Ile Asn Ile Glu Trp Asn Cys Asp Leu
225                 230                 235                 240 
Asp Lys Ala Ala Ser Glu Cys His Pro His Tyr Ser Phe Ser Arg Leu
                245                 250                 255     
Asp Asn Lys Leu Ser Lys Ser Val Ser Ser Gly Tyr Asn Phe Arg Phe
            260                 265                 270         
Ala Arg Tyr Tyr Arg Asp Ala Ala Gly Val Glu Phe Arg Thr Leu Met
        275                 280                 285             
Lys Ala Tyr Gly Ile Arg Phe Asp Val Met Val Asn Gly Lys Gly Ala
    290                 295                 300                 
Phe Phe Cys Asp Leu Val Leu Ile Tyr Leu Ile Lys Lys Arg Glu Phe
305                 310                 315                 320 
Tyr Arg Asp Lys Lys Tyr Glu Glu Val Arg Gly Leu Glu Asp Ser Ser
                325                 330                 335     
Gln Glu Ala Glu Asp Glu Ala Ser Gly Leu Gly Leu Ser Glu Gln Leu
            340                 345                 350         
Thr Ser Gly Pro Gly Leu Leu Gly Met Pro Glu Gln Gln Glu Leu Gln
        355                 360                 365             
Glu Pro Pro Glu Ala Lys Arg Gly Ser Ser Ser Gln Lys Gly Asn Gly
    370                 375                 380                 
Ser Val Cys Pro Gln Leu Leu Glu Pro His Arg Ser Thr
385                 390                 395         


<210> 2203
<211> 548
<212> PRT
<213> Homo sapiens

<400> 2203
Met Leu Lys Arg Lys Ala Glu Glu Gly Val Arg Val Ser Ile Leu Leu
 1               5                  10                  15      
Phe Lys Glu Val Glu Leu Ala Leu Gly Ile Asn Ser Gly Tyr Ser Lys
            20                  25                  30          
Arg Ala Leu Met Leu Leu His Pro Asn Ile Lys Val Met Arg His Pro
        35                  40                  45              
Asp Gln Val Thr Leu Trp Ala His His Glu Lys Leu Leu Val Val Asp
    50                  55                  60                  
Gln Val Val Ala Phe Leu Gly Gly Leu Asp Leu Ala Tyr Gly Arg Trp
65                  70                  75                  80  
Asp Asp Leu His Tyr Arg Leu Thr Asp Leu Gly Asp Ser Ser Glu Ser
                85                  90                  95      
Ala Ala Ser Gln Pro Pro Thr Pro Arg Pro Asp Ser Pro Ala Thr Pro
            100                 105                 110         
Asp Leu Ser His Asn Gln Phe Phe Trp Leu Gly Lys Asp Tyr Ser Asn
        115                 120                 125             
Leu Ile Thr Lys Asp Trp Val Gln Leu Asp Arg Pro Phe Glu Asp Phe
    130                 135                 140                 
Ile Asp Arg Glu Thr Thr Pro Arg Met Pro Trp Arg Asp Val Gly Val
145                 150                 155                 160 
Val Val His Gly Leu Pro Ala Arg Asp Leu Ala Arg His Phe Ile Gln
                165                 170                 175     
Arg Trp Asn Phe Thr Lys Thr Thr Lys Ala Lys Tyr Lys Thr Pro Thr
            180                 185                 190         
Tyr Pro Tyr Leu Leu Pro Lys Ser Thr Ser Thr Ala Asn Gln Leu Pro
        195                 200                 205             
Phe Thr Leu Pro Gly Gly Gln Cys Thr Thr Val Gln Val Leu Arg Ser
    210                 215                 220                 
Val Asp Arg Trp Ser Ala Gly Thr Leu Glu Asn Ser Ile Leu Asn Ala
225                 230                 235                 240 
Tyr Leu His Thr Ile Arg Glu Ser Gln His Phe Leu Tyr Ile Glu Asn
                245                 250                 255     
Gln Phe Phe Ile Ser Cys Ser Asp Gly Arg Thr Val Leu Asn Lys Val
            260                 265                 270         
Gly Asp Glu Ile Val Asp Arg Ile Leu Lys Ala His Lys Gln Gly Trp
        275                 280                 285             
Cys Tyr Arg Val Tyr Val Leu Leu Pro Leu Leu Pro Gly Phe Glu Gly
    290                 295                 300                 
Asp Ile Ser Thr Gly Gly Gly Asn Ser Ile Gln Ala Ile Leu His Phe
305                 310                 315                 320 
Thr Tyr Arg Thr Leu Cys Arg Gly Glu Tyr Ser Ile Leu His Arg Leu
                325                 330                 335     
Lys Ala Ala Met Gly Thr Ala Trp Arg Asp Tyr Ile Ser Ile Cys Gly
            340                 345                 350         
Leu Arg Thr His Gly Glu Leu Gly Gly His Pro Val Ser Glu Leu Ile
        355                 360                 365             
Tyr Ile His Ser Lys Val Leu Ile Ala Asp Asp Arg Thr Val Ile Ile
    370                 375                 380                 
Gly Ser Ala Asn Ile Asn Asp Arg Ser Leu Leu Gly Lys Arg Asp Ser
385                 390                 395                 400 
Glu Leu Ala Val Leu Ile Glu Asp Thr Glu Thr Glu Pro Ser Leu Met
                405                 410                 415     
Asn Gly Ala Glu Tyr Gln Ala Gly Arg Phe Ala Leu Ser Leu Arg Lys
            420                 425                 430         
His Cys Phe Gly Val Ile Leu Gly Ala Asn Thr Arg Pro Asp Leu Asp
        435                 440                 445             
Leu Arg Asp Pro Ile Cys Asp Asp Phe Phe Gln Leu Trp Gln Asp Met
    450                 455                 460                 
Ala Glu Ser Asn Ala Asn Ile Tyr Glu Gln Ile Phe Arg Cys Leu Pro
465                 470                 475                 480 
Ser Asn Ala Thr Arg Ser Leu Arg Thr Leu Arg Glu Tyr Val Ala Val
                485                 490                 495     
Glu Pro Leu Ala Thr Val Ser Pro Pro Leu Ala Arg Ser Glu Leu Thr
            500                 505                 510         
Gln Val Gln Gly His Leu Val His Phe Pro Leu Lys Phe Leu Glu Asp
        515                 520                 525             
Glu Ser Leu Leu Pro Pro Leu Gly Ser Lys Glu Gly Met Ile Pro Leu
    530                 535                 540                 
Glu Val Trp Thr
545             


<210> 2204
<211> 314
<212> PRT
<213> Homo sapiens

<400> 2204
Met Ala Ala Thr Ala Ser Ala Gly Ala Gly Gly Ile Asp Gly Lys Pro
 1               5                  10                  15      
Arg Thr Ser Pro Lys Ser Val Lys Phe Leu Phe Gly Gly Leu Ala Gly
            20                  25                  30          
Met Gly Ala Thr Val Phe Val Gln Pro Leu Asp Leu Val Lys Asn Arg
        35                  40                  45              
Met Gln Leu Ser Gly Glu Gly Ala Lys Thr Arg Glu Tyr Lys Thr Ser
    50                  55                  60                  
Phe His Ala Leu Thr Ser Ile Leu Lys Ala Glu Gly Leu Arg Gly Ile
65                  70                  75                  80  
Tyr Thr Gly Leu Ser Ala Gly Leu Leu Arg Gln Ala Thr Tyr Thr Thr
                85                  90                  95      
Thr Arg Leu Gly Ile Tyr Thr Val Leu Phe Glu Arg Leu Thr Gly Ala
            100                 105                 110         
Asp Gly Thr Pro Pro Gly Phe Leu Leu Lys Ala Val Ile Gly Met Thr
        115                 120                 125             
Ala Gly Ala Thr Gly Ala Phe Val Gly Thr Pro Ala Glu Val Ala Leu
    130                 135                 140                 
Ile Arg Met Thr Ala Asp Gly Arg Leu Pro Ala Asp Gln Arg Arg Gly
145                 150                 155                 160 
Tyr Lys Asn Val Phe Asn Ala Leu Ile Arg Ile Thr Arg Glu Glu Gly
                165                 170                 175     
Val Leu Thr Leu Trp Arg Gly Cys Ile Pro Thr Met Ala Arg Ala Val
            180                 185                 190         
Val Val Asn Ala Ala Gln Leu Ala Ser Tyr Ser Gln Ser Lys Gln Phe
        195                 200                 205             
Leu Leu Asp Ser Gly Tyr Phe Ser Asp Asn Ile Leu Cys His Phe Cys
    210                 215                 220                 
Ala Ser Met Ile Ser Gly Leu Val Thr Thr Ala Ala Ser Met Pro Val
225                 230                 235                 240 
Asp Ile Ala Lys Thr Arg Ile Gln Asn Met Arg Met Ile Asp Gly Lys
                245                 250                 255     
Pro Glu Tyr Lys Asn Gly Leu Asp Val Leu Phe Lys Val Val Arg Tyr
            260                 265                 270         
Glu Gly Phe Phe Ser Leu Trp Lys Gly Phe Thr Pro Tyr Tyr Ala Arg
        275                 280                 285             
Leu Gly Pro His Thr Val Leu Thr Phe Ile Phe Leu Glu Gln Met Asn
    290                 295                 300                 
Lys Ala Tyr Lys Arg Leu Phe Leu Ser Gly
305                 310                 


<210> 2205
<211> 153
<212> PRT
<213> Homo sapiens

<400> 2205
Met Ala Ala Val Glu His Arg His Ser Ser Gly Leu Pro Tyr Trp Pro
 1               5                  10                  15      
Tyr Leu Thr Ala Glu Thr Leu Lys Asn Arg Met Gly His Gln Pro Pro
            20                  25                  30          
Pro Pro Thr Gln Gln His Ser Ile Ile Asp Asn Ser Leu Ser Leu Lys
        35                  40                  45              
Thr Pro Ser Glu Cys Val Leu Tyr Pro Leu Pro Pro Ser Ala Asp Asp
    50                  55                  60                  
Asn Leu Lys Thr Pro Pro Glu Cys Leu Leu Thr Pro Leu Pro Pro Ser
65                  70                  75                  80  
Ala Leu Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Ala Glu Cys Leu
                85                  90                  95      
Leu Tyr Pro Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Pro
            100                 105                 110         
Glu Cys Leu Leu Thr Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala Asp
        115                 120                 125             
Asp Asn Leu Lys Thr Pro Pro Glu Cys Val Cys Ser Leu Pro Phe His
    130                 135                 140                 
Pro Gln Arg Met Ile Ile Ser Arg Asn
145                 150             


<210> 2206
<211> 876
<212> PRT
<213> Homo sapiens

<400> 2206
Met Glu Leu Ile Thr Ile Leu Glu Lys Thr Val Ser Pro Asp Arg Leu
 1               5                  10                  15      
Glu Leu Glu Ala Ala Gln Lys Phe Leu Glu Arg Ala Ala Val Glu Asn
            20                  25                  30          
Leu Pro Thr Phe Leu Val Glu Leu Ser Arg Val Leu Ala Asn Pro Gly
        35                  40                  45              
Asn Ser Gln Val Ala Arg Val Ala Ala Gly Leu Gln Ile Lys Asn Ser
    50                  55                  60                  
Leu Thr Ser Lys Asp Pro Asp Ile Lys Ala Gln Tyr Gln Gln Arg Trp
65                  70                  75                  80  
Leu Ala Ile Asp Ala Asn Ala Arg Arg Glu Val Lys Asn Tyr Val Leu
                85                  90                  95      
Gln Thr Leu Gly Thr Glu Thr Tyr Arg Pro Ser Ser Ala Ser Gln Cys
            100                 105                 110         
Val Ala Gly Ile Ala Cys Ala Glu Ile Pro Val Asn Gln Trp Pro Glu
        115                 120                 125             
Leu Ile Pro Gln Leu Val Ala Asn Val Thr Asn Pro Asn Ser Thr Glu
    130                 135                 140                 
His Met Lys Glu Ser Thr Leu Glu Ala Ile Gly Tyr Ile Cys Gln Asp
145                 150                 155                 160 
Ile Asp Pro Glu Gln Leu Gln Asp Lys Ser Asn Glu Ile Leu Thr Ala
                165                 170                 175     
Ile Ile Gln Gly Met Arg Lys Glu Glu Pro Ser Asn Asn Val Lys Leu
            180                 185                 190         
Ala Ala Thr Asn Ala Leu Leu Asn Ser Leu Glu Phe Thr Lys Ala Asn
        195                 200                 205             
Phe Asp Lys Glu Ser Glu Arg His Phe Ile Met Gln Val Val Cys Glu
    210                 215                 220                 
Ala Thr Gln Cys Pro Asp Thr Arg Val Arg Val Ala Ala Leu Gln Asn
225                 230                 235                 240 
Leu Val Lys Ile Met Ser Leu Tyr Tyr Gln Tyr Met Glu Thr Tyr Met
                245                 250                 255     
Gly Pro Ala Leu Phe Ala Ile Thr Ile Glu Ala Met Lys Ser Asp Ile
            260                 265                 270         
Asp Glu Val Ala Leu Gln Gly Ile Glu Phe Trp Ser Asn Val Cys Asp
        275                 280                 285             
Glu Glu Met Asp Leu Ala Ile Glu Ala Ser Glu Ala Ala Glu Gln Gly
    290                 295                 300                 
Arg Pro Pro Glu His Thr Ser Lys Phe Tyr Ala Lys Gly Ala Leu Gln
305                 310                 315                 320 
Tyr Leu Val Pro Ile Leu Thr Gln Thr Leu Thr Lys Gln Asp Glu Asn
                325                 330                 335     
Asp Asp Asp Asp Asp Trp Asn Pro Cys Lys Ala Ala Gly Val Cys Leu
            340                 345                 350         
Met Leu Leu Ala Thr Cys Cys Glu Asp Asp Ile Val Pro His Val Leu
        355                 360                 365             
Pro Phe Ile Lys Glu His Ile Lys Asn Pro Asp Trp Arg Tyr Arg Asp
    370                 375                 380                 
Ala Ala Val Met Ala Phe Gly Cys Ile Leu Glu Gly Pro Glu Pro Ser
385                 390                 395                 400 
Gln Leu Lys Pro Leu Val Ile Gln Ala Met Pro Thr Leu Ile Glu Leu
                405                 410                 415     
Met Lys Asp Pro Ser Val Val Val Arg Asp Thr Ala Ala Trp Thr Val
            420                 425                 430         
Gly Arg Ile Cys Glu Leu Leu Pro Glu Ala Ala Ile Asn Asp Val Tyr
        435                 440                 445             
Leu Ala Pro Leu Leu Gln Cys Leu Ile Glu Gly Leu Ser Ala Glu Pro
    450                 455                 460                 
Arg Val Ala Ser Asn Val Cys Trp Ala Phe Ser Ser Leu Ala Glu Ala
465                 470                 475                 480 
Ala Tyr Glu Ala Ala Asp Val Ala Asp Asp Gln Glu Glu Pro Ala Thr
                485                 490                 495     
Tyr Cys Leu Ser Ser Ser Phe Glu Leu Ile Val Gln Lys Leu Leu Glu
            500                 505                 510         
Thr Thr Asp Arg Pro Asp Gly His Gln Asn Asn Leu Arg Ser Ser Ala
        515                 520                 525             
Tyr Glu Ser Leu Met Glu Ile Val Lys Asn Ser Ala Lys Asp Cys Tyr
    530                 535                 540                 
Pro Ala Val Gln Lys Thr Thr Leu Val Ile Met Glu Arg Leu Gln Gln
545                 550                 555                 560 
Val Leu Gln Met Glu Ser His Ile Gln Ser Thr Ser Asp Arg Ile Gln
                565                 570                 575     
Phe Asn Asp Leu Gln Ser Leu Leu Cys Ala Thr Leu Gln Asn Val Leu
            580                 585                 590         
Arg Lys Val Gln His Gln Asp Ala Leu Gln Ile Ser Asp Val Val Met
        595                 600                 605             
Ala Ser Leu Leu Arg Met Phe Gln Ser Thr Ala Gly Ser Gly Gly Val
    610                 615                 620                 
Gln Glu Asp Ala Leu Met Ala Val Ser Thr Leu Val Glu Val Leu Gly
625                 630                 635                 640 
Gly Glu Phe Leu Lys Tyr Met Glu Ala Phe Lys Pro Phe Leu Gly Ile
                645                 650                 655     
Gly Leu Lys Asn Tyr Ala Glu Tyr Gln Val Cys Leu Ala Ala Val Gly
            660                 665                 670         
Leu Val Gly Asp Leu Cys Arg Ala Leu Gln Ser Asn Ile Ile Pro Phe
        675                 680                 685             
Cys Asp Glu Val Met Gln Leu Leu Leu Glu Asn Leu Gly Asn Glu Asn
    690                 695                 700                 
Val His Arg Ser Val Lys Pro Gln Ile Leu Ser Val Phe Gly Asp Ile
705                 710                 715                 720 
Ala Leu Ala Ile Gly Gly Glu Phe Lys Lys Tyr Leu Glu Val Val Leu
                725                 730                 735     
Asn Thr Leu Gln Gln Ala Ser Gln Ala Gln Val Asp Lys Ser Asp Tyr
            740                 745                 750         
Asp Met Val Asp Tyr Leu Asn Glu Leu Arg Glu Ser Cys Leu Glu Ala
        755                 760                 765             
Tyr Thr Gly Ile Val Gln Gly Leu Lys Gly Asp Gln Glu Asn Val His
    770                 775                 780                 
Pro Asp Val Met Leu Val Gln Pro Arg Val Glu Phe Ile Leu Ser Phe
785                 790                 795                 800 
Ile Asp His Ile Ala Gly Asp Glu Asp His Thr Asp Gly Val Val Ala
                805                 810                 815     
Cys Ala Ala Gly Leu Ile Gly Asp Leu Cys Thr Ala Phe Gly Lys Asp
            820                 825                 830         
Val Leu Lys Leu Val Glu Ala Arg Pro Met Ile His Glu Leu Leu Thr
        835                 840                 845             
Glu Gly Arg Arg Ser Lys Thr Asn Lys Ala Lys Thr Leu Ala Thr Trp
    850                 855                 860                 
Ala Thr Lys Glu Leu Arg Lys Leu Lys Asn Gln Ala
865                 870                 875     


<210> 2207
<211> 105
<212> PRT
<213> Homo sapiens

<400> 2207
Met Ala Met Ser Ile Cys His Arg Gly Thr Gly Ile Ala Leu Ser Ala
 1               5                  10                  15      
Gly Val Ser Leu Phe Gly Met Leu Ala Val Leu Leu Pro Gly Asn Phe
            20                  25                  30          
Glu Ser Tyr Leu Glu Leu Val Lys Ser Leu Cys Leu Gly Pro Ala Leu
        35                  40                  45              
Ile His Thr Ala Lys Phe Ala Leu Val Phe Pro Leu Met Tyr His Thr
    50                  55                  60                  
Trp Asn Gly Ile Arg His Leu Met Trp Asp Leu Gly Lys Gly Leu Lys
65                  70                  75                  80  
Ile Pro Gln Leu Tyr Gln Ser Gly Val Val Val Leu Val Leu Thr Val
                85                  90                  95      
Leu Ser Ser Met Gly Leu Ala Ala Met
            100                 105 


<210> 2208
<211> 111
<212> PRT
<213> Homo sapiens

<400> 2208
Met Leu Pro His Asn Ile Pro Ser Ser Leu Ser Leu Leu Thr Ser Met
 1               5                  10                  15      
Val Asp Asp Met Trp His Tyr Ala Gly Asp Gln Ser Thr Asp Phe Asn
            20                  25                  30          
Trp Tyr Thr Arg Arg Ala Met Leu Ala Ala Ile Tyr Asn Thr Thr Glu
        35                  40                  45              
Leu Val Met Met Gln Asp Ser Ser Pro Asp Phe Glu Asp Thr Trp Arg
    50                  55                  60                  
Phe Leu Glu Asn Arg Val Asn Asp Ala Met Asn Met Gly His Thr Ala
65                  70                  75                  80  
Lys Gln Val Lys Ser Thr Gly Glu Ala Leu Val Gln Gly Leu Met Gly
                85                  90                  95      
Ala Ala Val Thr Leu Lys Asn Leu Thr Gly Leu Asn Gln Arg Arg
            100                 105                 110     


<210> 2209
<211> 732
<212> PRT
<213> Homo sapiens

<400> 2209
Met Pro Leu Thr Ser Ile Leu Pro Leu Gln Val Glu Glu Ser Ala Leu
 1               5                  10                  15      
Pro Ser Ala Val Leu Ala Asn Gly Gly Lys Met Pro Phe Thr Met Pro
            20                  25                  30          
Glu Ala Phe Leu Asp Asp Gly Asp Met Val Leu Gly Asp Glu Leu Asp
        35                  40                  45              
Asp Leu Leu Asp Ser Ala Pro Glu Thr Asn Glu Thr Val Met Pro Ser
    50                  55                  60                  
Ala Leu Val Arg Gly Pro Leu Gln Thr Ala Ser Val Ser Pro Ser Met
65                  70                  75                  80  
Pro Phe Ser Ala Ser Leu Leu Gly Thr Leu Pro Ile Gly Ala Arg Tyr
                85                  90                  95      
Ala Pro Pro Pro Ser Phe Ser Glu Phe Tyr Pro Pro Leu Thr Ser Ser
            100                 105                 110         
Leu Glu Asp Phe Cys Ser Ser Leu Asn Ser Phe Ser Met Ser Glu Ser
        115                 120                 125             
Lys Arg Asp Leu Ser Thr Ser Thr Ser Arg Glu Gly Thr Pro Leu Asn
    130                 135                 140                 
Asn Ser Asn Ser Ser Leu Leu Leu Met Asn Gly Pro Gly Ser Leu Phe
145                 150                 155                 160 
Ala Ser Glu Asn Phe Leu Gly Ile Ser Ser Gln Pro Arg Asn Asp Phe
                165                 170                 175     
Gly Asn Phe Phe Gly Ser Ala Val Thr Lys Pro Ser Ser Ser Val Thr
            180                 185                 190         
Pro Arg His Pro Leu Glu Gly Thr His Glu Leu Arg Gln Ala Cys Gln
        195                 200                 205             
Ile Cys Phe Val Lys Ser Gly Pro Lys Leu Met Asp Phe Thr Tyr His
    210                 215                 220                 
Ala Asn Ile Asp His Lys Cys Lys Lys Asp Ile Leu Ile Gly Arg Ile
225                 230                 235                 240 
Lys Asn Val Glu Asp Lys Ser Trp Lys Lys Ile Arg Pro Arg Pro Thr
                245                 250                 255     
Lys Thr Asn Tyr Glu Gly Pro Tyr Tyr Ile Cys Lys Asp Val Ala Ala
            260                 265                 270         
Glu Glu Glu Cys Arg Tyr Ser Gly His Cys Thr Phe Ala Tyr Cys Gln
        275                 280                 285             
Glu Glu Ile Asp Val Trp Thr Leu Glu Arg Lys Gly Ala Phe Ser Arg
    290                 295                 300                 
Glu Ala Phe Phe Gly Gly Asn Gly Lys Ile Asn Leu Thr Val Phe Lys
305                 310                 315                 320 
Leu Leu Gln Glu His Leu Gly Glu Phe Ile Phe Leu Cys Glu Lys Cys
                325                 330                 335     
Phe Asp His Lys Pro Arg Met Ile Ser Lys Arg Asn Lys Asp Asn Ser
            340                 345                 350         
Thr Ala Cys Ser His Pro Val Thr Lys His Glu Phe Glu Asp Asn Lys
        355                 360                 365             
Cys Leu Val His Ile Leu Arg Glu Thr Thr Val Lys Tyr Ser Lys Ile
    370                 375                 380                 
Arg Ser Phe His Gly Gln Cys Gln Leu Asp Leu Cys Arg His Glu Val
385                 390                 395                 400 
Arg Tyr Gly Cys Leu Arg Glu Asp Glu Cys Phe Tyr Ala His Ser Leu
                405                 410                 415     
Val Glu Leu Lys Val Trp Ile Met Gln Asn Glu Thr Gly Ile Ser His
            420                 425                 430         
Asp Ala Ile Ala Gln Glu Ser Lys Arg Tyr Trp Gln Asn Leu Glu Ala
        435                 440                 445             
Asn Val Pro Gly Ala Gln Val Leu Gly Asn Gln Ile Met Pro Gly Phe
    450                 455                 460                 
Leu Asn Met Lys Ile Lys Phe Val Cys Ala Gln Cys Leu Arg Asn Gly
465                 470                 475                 480 
Gln Val Ile Glu Pro Asp Lys Asn Arg Lys Tyr Cys Ser Ala Lys Ala
                485                 490                 495     
Arg His Ser Trp Thr Lys Asp Arg Arg Ala Met Arg Val Met Ser Ile
            500                 505                 510         
Glu Arg Lys Lys Trp Met Asn Ile Arg Pro Leu Pro Thr Lys Lys Gln
        515                 520                 525             
Met Pro Leu Gln Phe Asp Leu Cys Asn His Ile Ala Ser Gly Lys Lys
    530                 535                 540                 
Cys Gln Tyr Val Gly Asn Cys Ser Phe Ala His Ser Pro Glu Glu Arg
545                 550                 555                 560 
Glu Val Trp Thr Tyr Met Lys Glu Asn Gly Ile Gln Asp Met Glu Gln
                565                 570                 575     
Phe Tyr Glu Leu Trp Leu Lys Ser Gln Lys Asn Glu Lys Ser Glu Asp
            580                 585                 590         
Ile Ala Ser Gln Ser Asn Lys Glu Asn Gly Lys Gln Ile His Met Pro
        595                 600                 605             
Thr Asp Tyr Ala Glu Val Thr Val Asp Phe His Cys Trp Met Cys Gly
    610                 615                 620                 
Lys Asn Cys Asn Ser Glu Lys Gln Trp Gln Gly His Ile Ser Ser Glu
625                 630                 635                 640 
Lys His Lys Glu Lys Val Phe His Thr Glu Asp Asp Gln Tyr Cys Trp
                645                 650                 655     
Gln His Arg Phe Pro Thr Gly Tyr Phe Ser Ile Cys Asp Arg Tyr Met
            660                 665                 670         
Asn Gly Thr Cys Pro Glu Gly Asn Ser Cys Lys Phe Ala His Gly Asn
        675                 680                 685             
Ala Glu Leu His Glu Trp Glu Glu Arg Arg Asp Ala Leu Lys Met Lys
    690                 695                 700                 
Leu Asn Lys Ala Arg Lys Asp His Leu Ile Gly Pro Asn Asp Asn Asp
705                 710                 715                 720 
Phe Gly Lys Tyr Ser Phe Leu Phe Lys Asp Leu Asn
                725                 730         


<210> 2210
<211> 142
<212> PRT
<213> Homo sapiens

<400> 2210
Met Gly Ala Pro Thr Leu Pro Pro Ala Trp Gln Pro Phe Leu Lys Asp
 1               5                  10                  15      
His Arg Ile Ser Thr Phe Lys Asn Trp Pro Phe Leu Glu Gly Cys Ala
            20                  25                  30          
Cys Thr Pro Glu Arg Met Ala Glu Ala Gly Phe Ile His Cys Pro Thr
        35                  40                  45              
Glu Asn Glu Pro Asp Leu Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu
    50                  55                  60                  
Glu Gly Trp Glu Pro Asp Asp Asp Pro Ile Glu Glu His Lys Lys His
65                  70                  75                  80  
Ser Ser Gly Cys Ala Phe Leu Ser Val Lys Lys Gln Phe Glu Glu Leu
                85                  90                  95      
Thr Leu Gly Glu Phe Leu Lys Leu Asp Arg Glu Arg Ala Lys Asn Lys
            100                 105                 110         
Ile Ala Lys Glu Thr Asn Asn Lys Lys Lys Glu Phe Glu Glu Thr Ala
        115                 120                 125             
Glu Lys Val Arg Arg Ala Ile Glu Gln Leu Ala Ala Met Asp
    130                 135                 140         


<210> 2211
<211> 394
<212> PRT
<213> Homo sapiens

<400> 2211
Met Trp Leu Pro Arg Val Ser Ser Thr Ala Val Thr Ala Leu Leu Leu
 1               5                  10                  15      
Ala Gln Thr Phe Leu Leu Leu Phe Leu Val Ser Arg Pro Gly Pro Ser
            20                  25                  30          
Ser Pro Ala Gly Gly Glu Ala Arg Val His Val Leu Val Leu Ser Ser
        35                  40                  45              
Trp Arg Ser Gly Ser Ser Phe Val Gly Gln Leu Phe Asn Gln His Pro
    50                  55                  60                  
Asp Val Phe Tyr Leu Met Glu Pro Ala Trp His Val Trp Thr Thr Leu
65                  70                  75                  80  
Ser Gln Gly Ser Ala Ala Thr Leu His Met Ala Val Arg Asp Leu Val
                85                  90                  95      
Arg Ser Val Phe Leu Cys Asp Met Asp Val Phe Asp Ala Tyr Leu Pro
            100                 105                 110         
Trp Arg Arg Asn Leu Ser Asp Leu Phe Gln Trp Ala Val Ser Arg Ala
        115                 120                 125             
Leu Cys Ser Pro Pro Ala Cys Ser Ala Phe Pro Arg Gly Ala Ile Ser
    130                 135                 140                 
Lys Gln Asp Val Cys Lys Thr Leu Cys Ala Arg Gln Pro Phe Ser Leu
145                 150                 155                 160 
Ala Arg Glu Ala Cys Arg Ser Tyr Ser His Val Val Leu Lys Glu Val
                165                 170                 175     
Arg Phe Phe Asn Leu Gln Val Leu Tyr Pro Leu Leu Ser Asp Pro Ala
            180                 185                 190         
Leu Asn Leu Arg Ile Val His Leu Val Arg Asp Pro Arg Ala Val Leu
        195                 200                 205             
Arg Ser Arg Glu Ala Ala Gly Pro Ile Leu Ala Arg Asp Asn Gly Ile
    210                 215                 220                 
Val Leu Gly Thr Asn Gly Lys Trp Val Glu Ala Asp Pro His Leu Arg
225                 230                 235                 240 
Leu Ile Arg Glu Val Cys Arg Ser His Val Arg Ile Ala Glu Ala Ala
                245                 250                 255     
Thr Leu Lys Pro Pro Pro Phe Leu Arg Gly Arg Tyr Arg Leu Val Arg
            260                 265                 270         
Phe Glu Asp Leu Ala Arg Glu Pro Leu Ala Glu Ile Arg Ala Leu Tyr
        275                 280                 285             
Ala Phe Thr Gly Leu Thr Leu Thr Pro Gln Leu Glu Ala Trp Ile His
    290                 295                 300                 
Asn Ile Thr His Gly Arg Gly Ser Ala Ser Gln Ser Lys Pro Ser Ile
305                 310                 315                 320 
Leu Arg Leu Gly Met Arg Ala Thr Ser Pro Arg Pro Gly Ala Thr Arg
                325                 330                 335     
Cys Pro Ser Leu Arg Ser Cys Ala Cys Arg Arg Cys Ala Pro Ala Arg
            340                 345                 350         
Cys Ser Cys Trp Ala Thr Gly Leu Cys Thr Leu Arg Thr Ser Ser Val
        355                 360                 365             
Thr Ser Pro Trp Ile Trp Cys Cys His Glu Ala Gln Thr Thr Ser Ala
    370                 375                 380                 
Gly His Arg Leu Thr Glu Asn Ser Gly Pro
385                 390                 


<210> 2212
<211> 1479
<212> PRT
<213> Homo sapiens

<400> 2212
Met Gly Pro Gly Arg Pro Ala Pro Ala Pro Trp Pro Arg His Leu Leu
 1               5                  10                  15      
Arg Cys Val Leu Leu Leu Gly Cys Leu His Leu Gly Arg Pro Gly Ala
            20                  25                  30          
Pro Gly Asp Ala Ala Leu Pro Glu Pro Asn Ile Phe Leu Ile Phe Ser
        35                  40                  45              
His Gly Leu Gln Gly Cys Leu Glu Ala Gln Gly Gly Gln Val Arg Val
    50                  55                  60                  
Thr Pro Ala Cys Asn Thr Ser Leu Pro Ala Gln Arg Trp Lys Trp Val
65                  70                  75                  80  
Ser Arg Asn Arg Leu Phe Asn Leu Gly Thr Met Gln Cys Leu Gly Thr
                85                  90                  95      
Gly Trp Pro Gly Thr Asn Thr Thr Ala Ser Leu Gly Met Tyr Glu Cys
            100                 105                 110         
Asp Arg Glu Ala Leu Asn Leu Arg Trp His Cys Arg Thr Leu Gly Asp
        115                 120                 125             
Gln Leu Ser Leu Leu Leu Gly Ala Arg Thr Ser Asn Ile Ser Lys Pro
    130                 135                 140                 
Gly Thr Leu Glu Arg Gly Asp Gln Thr Arg Ser Gly Gln Trp Arg Ile
145                 150                 155                 160 
Tyr Gly Ser Glu Glu Asp Leu Cys Ala Leu Pro Tyr His Glu Val Tyr
                165                 170                 175     
Thr Ile Gln Gly Asn Ser His Gly Lys Pro Cys Thr Ile Pro Phe Lys
            180                 185                 190         
Tyr Asp Asn Gln Trp Phe His Gly Cys Thr Ser Thr Gly Arg Glu Asp
        195                 200                 205             
Gly His Leu Trp Cys Ala Thr Thr Gln Asp Tyr Gly Lys Asp Glu Arg
    210                 215                 220                 
Trp Gly Phe Cys Pro Ile Lys Ser Asn Asp Cys Glu Thr Phe Trp Asp
225                 230                 235                 240 
Lys Asp Gln Leu Thr Asp Ser Cys Tyr Gln Phe Asn Phe Gln Ser Thr
                245                 250                 255     
Leu Ser Trp Arg Glu Ala Trp Ala Ser Cys Glu Gln Gln Gly Ala Asp
            260                 265                 270         
Leu Leu Ser Ile Thr Glu Ile His Glu Gln Thr Tyr Ile Asn Gly Leu
        275                 280                 285             
Leu Thr Gly Tyr Ser Ser Thr Leu Trp Ile Gly Leu Asn Asp Leu Asp
    290                 295                 300                 
Thr Ser Gly Gly Trp Gln Trp Ser Asp Asn Ser Pro Leu Lys Tyr Leu
305                 310                 315                 320 
Asn Trp Glu Ser Asp Gln Pro Asp Asn Pro Ser Glu Glu Asn Cys Gly
                325                 330                 335     
Val Ile Arg Thr Glu Ser Ser Gly Gly Trp Gln Asn Arg Asp Cys Ser
            340                 345                 350         
Ile Ala Leu Pro Tyr Val Cys Lys Lys Lys Pro Asn Ala Thr Ala Glu
        355                 360                 365             
Pro Thr Pro Pro Asp Arg Trp Ala Asn Val Lys Val Glu Cys Glu Pro
    370                 375                 380                 
Ser Trp Gln Pro Phe Gln Gly His Cys Tyr Arg Leu Gln Ala Glu Lys
385                 390                 395                 400 
Arg Ser Trp Gln Glu Ser Lys Lys Ala Cys Leu Arg Gly Gly Gly Asp
                405                 410                 415     
Leu Val Ser Ile His Ser Met Ala Glu Leu Glu Phe Ile Thr Lys Gln
            420                 425                 430         
Ile Lys Gln Glu Val Glu Glu Leu Trp Ile Gly Leu Asn Asp Leu Lys
        435                 440                 445             
Leu Gln Met Asn Phe Glu Trp Ser Asp Gly Ser Leu Val Ser Phe Thr
    450                 455                 460                 
His Trp His Pro Phe Glu Pro Asn Asn Phe Arg Asp Ser Leu Glu Asp
465                 470                 475                 480 
Cys Val Thr Ile Trp Gly Pro Glu Gly Arg Trp Asn Asp Ser Pro Cys
                485                 490                 495     
Asn Gln Ser Leu Pro Ser Ile Cys Lys Lys Ala Gly Gln Leu Ser Gln
            500                 505                 510         
Gly Ala Ala Glu Glu Asp His Gly Cys Arg Lys Gly Trp Thr Trp His
        515                 520                 525             
Ser Pro Ser Cys Tyr Trp Leu Gly Glu Asp Gln Val Thr Tyr Ser Glu
    530                 535                 540                 
Ala Arg Arg Leu Cys Thr Asp His Gly Ser Gln Leu Val Thr Ile Thr
545                 550                 555                 560 
Asn Arg Phe Glu Gln Ala Phe Val Ser Ser Leu Ile Tyr Asn Trp Glu
                565                 570                 575     
Gly Glu Tyr Phe Trp Thr Ala Leu Gln Asp Leu Asn Ser Thr Gly Ser
            580                 585                 590         
Phe Phe Trp Leu Ser Gly Asp Glu Val Met Tyr Thr His Trp Asn Arg
        595                 600                 605             
Asp Gln Pro Gly Tyr Ser Arg Gly Gly Cys Val Ala Leu Ala Thr Gly
    610                 615                 620                 
Ser Ala Met Gly Leu Trp Glu Val Lys Asn Cys Thr Ser Phe Arg Ala
625                 630                 635                 640 
Arg Tyr Ile Cys Arg Gln Ser Leu Gly Thr Pro Val Thr Pro Glu Leu
                645                 650                 655     
Pro Gly Pro Asp Pro Thr Pro Ser Leu Thr Gly Ser Cys Pro Gln Gly
            660                 665                 670         
Trp Ala Ser Asp Thr Lys Leu Arg Tyr Cys Tyr Lys Val Phe Ser Ser
        675                 680                 685             
Glu Arg Leu Gln Asp Lys Lys Ser Trp Val Gln Ala Gln Gly Ala Cys
    690                 695                 700                 
Gln Glu Leu Gly Ala Gln Leu Leu Ser Leu Ala Ser Tyr Glu Glu Glu
705                 710                 715                 720 
His Phe Val Ala Asn Met Leu Asn Lys Ile Phe Gly Glu Ser Glu Pro
                725                 730                 735     
Glu Ile His Glu Gln His Trp Phe Trp Ile Gly Leu Asn Arg Arg Asp
            740                 745                 750         
Pro Arg Gly Gly Gln Ser Trp Arg Trp Ser Asp Gly Val Gly Phe Ser
        755                 760                 765             
Tyr His Asn Phe Asp Arg Ser Arg His Asp Asp Asp Asp Ile Arg Gly
    770                 775                 780                 
Cys Ala Val Leu Asp Leu Ala Ser Leu Gln Trp Val Ala Met Gln Cys
785                 790                 795                 800 
Asp Thr Gln Leu Asp Trp Ile Cys Lys Ile Pro Arg Gly Thr Asp Val
                805                 810                 815     
Arg Glu Pro Asp Asp Ser Pro Gln Gly Arg Arg Glu Trp Leu Arg Phe
            820                 825                 830         
Gln Glu Ala Glu Tyr Lys Phe Phe Glu His His Ser Thr Trp Ala Gln
        835                 840                 845             
Ala Gln Arg Ile Cys Thr Trp Phe Gln Ala Glu Leu Thr Ser Val His
    850                 855                 860                 
Ser Gln Ala Glu Leu Asp Phe Leu Ser His Asn Leu Gln Lys Phe Ser
865                 870                 875                 880 
Arg Ala Gln Glu Gln His Trp Trp Ile Gly Leu His Thr Ser Glu Ser
                885                 890                 895     
Asp Gly Arg Phe Arg Trp Thr Asp Gly Ser Ile Ile Asn Phe Ile Ser
            900                 905                 910         
Trp Ala Pro Gly Lys Pro Arg Pro Val Gly Lys Asp Lys Lys Cys Val
        915                 920                 925             
Tyr Met Thr Ala Ser Arg Glu Asp Trp Gly Asp Gln Arg Cys Leu Thr
    930                 935                 940                 
Ala Leu Pro Tyr Ile Cys Lys Arg Ser Asn Val Thr Lys Glu Thr Gln
945                 950                 955                 960 
Pro Pro Asp Leu Pro Thr Thr Ala Leu Gly Gly Cys Pro Ser Asp Trp
                965                 970                 975     
Ile Gln Phe Leu Asn Lys Cys Phe Gln Val Gln Gly Gln Glu Pro Gln
            980                 985                 990         
Ser Arg Val Lys Trp Ser Glu Ala Gln Phe Ser Cys Glu Gln Gln Glu
        995                 1000                1005            
Ala Gln Leu Val Thr Ile Thr Asn Pro Leu Glu Gln Ala Phe Ile Thr
    1010                1015                1020                
Ala Ser Leu Pro Asn Val Thr Phe Asp Leu Trp Ile Gly Leu His Ala
1025                1030                1035                1040
Ser Gln Arg Asp Phe Gln Trp Val Glu Gln Glu Pro Leu Met Tyr Ala
                1045                1050                1055    
Asn Trp Ala Pro Gly Glu Pro Ser Gly Pro Ser Pro Ala Pro Ser Gly
            1060                1065                1070        
Asn Lys Pro Thr Ser Cys Ala Val Val Leu His Ser Pro Ser Ala His
        1075                1080                1085            
Phe Thr Gly Arg Trp Asp Asp Arg Ser Cys Thr Glu Glu Thr His Gly
    1090                1095                1100                
Phe Ile Cys Gln Lys Gly Thr Asp Pro Ser Leu Ser Pro Ser Pro Ala
1105                1110                1115                1120
Ala Leu Pro Pro Ala Pro Gly Thr Glu Leu Ser Tyr Leu Asn Gly Thr
                1125                1130                1135    
Phe Arg Leu Leu Gln Lys Pro Leu Arg Trp His Asp Ala Leu Leu Leu
            1140                1145                1150        
Cys Glu Ser His Asn Ala Ser Leu Ala Tyr Val Pro Asp Pro Tyr Thr
        1155                1160                1165            
Gln Ala Phe Leu Thr Gln Ala Ala Arg Gly Leu Arg Thr Pro Leu Trp
    1170                1175                1180                
Ile Gly Leu Ala Gly Glu Glu Gly Ser Arg Arg Tyr Ser Trp Val Ser
1185                1190                1195                1200
Glu Glu Pro Leu Asn Tyr Val Gly Trp Gln Asp Gly Glu Pro Gln Gln
                1205                1210                1215    
Pro Gly Gly Cys Thr Tyr Val Asp Val Asp Gly Ala Trp Arg Thr Thr
            1220                1225                1230        
Ser Cys Asp Thr Lys Leu Gln Gly Ala Val Cys Gly Val Ser Ser Gly
        1235                1240                1245            
Pro Pro Pro Pro Arg Arg Ile Ser Tyr His Gly Ser Cys Pro Gln Gly
    1250                1255                1260                
Leu Ala Asp Ser Ala Trp Ile Pro Phe Arg Glu His Cys Tyr Ser Phe
1265                1270                1275                1280
His Met Glu Leu Leu Leu Gly His Lys Glu Ala Arg Gln Arg Cys Gln
                1285                1290                1295    
Arg Ala Gly Gly Ala Val Leu Ser Ile Leu Asp Glu Met Glu Asn Val
            1300                1305                1310        
Phe Val Trp Glu His Leu Gln Ser Tyr Glu Gly Gln Ser Arg Gly Ala
        1315                1320                1325            
Trp Leu Gly Met Asn Phe Asn Pro Lys Gly Gly Thr Leu Val Trp Gln
    1330                1335                1340                
Asp Asn Thr Ala Val Asn Tyr Ser Asn Trp Gly Pro Pro Gly Leu Gly
1345                1350                1355                1360
Pro Ser Met Leu Ser His Asn Ser Cys Tyr Trp Ile Gln Ser Asn Ser
                1365                1370                1375    
Gly Leu Trp Arg Pro Gly Ala Cys Thr Asn Ile Thr Met Gly Val Val
            1380                1385                1390        
Cys Lys Leu Pro Arg Gly Glu Gln Ser Ser Phe Ser Pro Ser Ala Leu
        1395                1400                1405            
Pro Glu Asn Pro Ala Ala Leu Val Val Val Leu Met Ala Val Leu Leu
    1410                1415                1420                
Leu Leu Ala Leu Leu Thr Ala Ala Leu Ile Leu Tyr Arg Arg Arg Gln
1425                1430                1435                1440
Ser Ile Glu Arg Gly Ala Phe Glu Gly Ala Arg Tyr Ser Arg Ser Ser
                1445                1450                1455    
Ser Ser Pro Thr Glu Ala Thr Glu Lys Asn Ile Leu Val Ser Asp Met
            1460                1465                1470        
Glu Met Asn Glu Gln Gln Glu
        1475                


<210> 2213
<211> 454
<212> PRT
<213> Homo sapiens

<400> 2213
Met Asp Glu Leu Leu Arg Arg Ala Val Pro Pro Thr Pro Ala Tyr Glu
 1               5                  10                  15      
Leu Arg Glu Lys Thr Pro Ala Pro Ala Glu Gly Gln Cys Ala Asp Phe
            20                  25                  30          
Val Ser Phe Tyr Gly Gly Leu Ala Glu Thr Ala Gln Arg Ala Glu Leu
        35                  40                  45              
Leu Gly Arg Leu Ala Arg Gly Phe Gly Val Asp His Gly Gln Val Ala
    50                  55                  60                  
Glu Gln Ser Ala Gly Val Leu His Leu Arg Gln Gln Gln Arg Glu Ala
65                  70                  75                  80  
Ala Val Leu Leu Gln Ala Glu Asp Arg Leu Arg Tyr Ala Leu Val Pro
                85                  90                  95      
Arg Tyr Arg Gly Leu Phe His His Ile Ser Lys Leu Asp Gly Gly Val
            100                 105                 110         
Arg Phe Leu Val Gln Leu Arg Ala Asp Leu Leu Glu Ala Gln Ala Leu
        115                 120                 125             
Lys Leu Val Glu Gly Pro Asp Val Arg Glu Met Asn Gly Val Leu Lys
    130                 135                 140                 
Gly Met Leu Ser Glu Trp Phe Ser Ser Gly Phe Leu Asn Leu Glu Arg
145                 150                 155                 160 
Val Thr Trp His Ser Pro Cys Glu Val Leu Gln Lys Ile Ser Glu Ala
                165                 170                 175     
Glu Ala Val His Pro Val Lys Asn Trp Met Asp Met Lys Arg Arg Val
            180                 185                 190         
Gly Pro Tyr Arg Arg Cys Tyr Phe Phe Ser His Cys Ser Thr Pro Gly
        195                 200                 205             
Glu Pro Leu Val Val Leu His Val Ala Leu Thr Gly Asp Ile Ser Ser
    210                 215                 220                 
Asn Ile Gln Ala Ile Val Lys Glu His Pro Pro Ser Glu Thr Glu Glu
225                 230                 235                 240 
Lys Asn Lys Ile Thr Ala Ala Ile Phe Tyr Ser Ile Ser Leu Thr Gln
                245                 250                 255     
Gln Gly Leu Gln Gly Val Glu Leu Gly Thr Phe Leu Ile Lys Arg Val
            260                 265                 270         
Val Lys Glu Leu Gln Arg Glu Phe Pro His Leu Gly Val Phe Ser Ser
        275                 280                 285             
Leu Ser Pro Ile Pro Gly Phe Thr Lys Trp Leu Leu Gly Leu Leu Asn
    290                 295                 300                 
Ser Gln Thr Lys Glu His Gly Arg Asn Glu Leu Phe Thr Asp Ser Glu
305                 310                 315                 320 
Cys Lys Glu Ile Ser Glu Ile Thr Gly Gly Pro Ile Asn Glu Thr Leu
                325                 330                 335     
Lys Leu Leu Leu Ser Ser Ser Glu Trp Val Gln Ser Glu Lys Leu Val
            340                 345                 350         
Arg Ala Leu Gln Thr Pro Leu Met Arg Leu Cys Ala Trp Tyr Leu Tyr
        355                 360                 365             
Gly Glu Lys His Arg Gly Tyr Ala Leu Asn Pro Val Ala Asn Phe His
    370                 375                 380                 
Leu Gln Asn Gly Ala Val Leu Trp Arg Ile Asn Trp Met Ala Asp Val
385                 390                 395                 400 
Ser Leu Arg Gly Ile Thr Gly Ser Cys Gly Leu Met Ala Asn Tyr Arg
                405                 410                 415     
Tyr Phe Leu Glu Glu Thr Gly Pro Asn Ser Thr Ser Tyr Leu Gly Ser
            420                 425                 430         
Lys Ile Ile Lys Ala Ser Glu Gln Val Leu Ser Leu Val Ala Gln Phe
        435                 440                 445             
Gln Lys Asn Ser Lys Leu
    450                 


<210> 2214
<211> 453
<212> PRT
<213> Homo sapiens

<400> 2214
Met Lys Leu Leu Thr Arg Ala Gly Ser Phe Ser Arg Phe Tyr Ser Leu
 1               5                  10                  15      
Lys Val Ala Pro Lys Val Lys Ala Thr Ala Ala Pro Ala Gly Ala Pro
            20                  25                  30          
Pro Gln Pro Gln Asp Leu Glu Phe Thr Lys Leu Pro Asn Gly Leu Val
        35                  40                  45              
Ile Ala Ser Leu Glu Asn Tyr Ser Pro Val Ser Arg Ile Gly Leu Phe
    50                  55                  60                  
Ile Lys Ala Gly Ser Arg Tyr Glu Asp Phe Ser Asn Leu Gly Thr Thr
65                  70                  75                  80  
His Leu Leu Arg Leu Thr Ser Ser Leu Thr Thr Lys Gly Ala Ser Ser
                85                  90                  95      
Phe Lys Ile Thr Arg Gly Ile Glu Ala Val Gly Gly Lys Leu Ser Val
            100                 105                 110         
Thr Ala Thr Arg Glu Asn Met Ala Tyr Thr Val Glu Cys Leu Arg Gly
        115                 120                 125             
Asp Val Asp Ile Leu Met Glu Phe Leu Leu Asn Val Thr Thr Ala Pro
    130                 135                 140                 
Glu Phe Arg Arg Trp Glu Val Ala Asp Leu Gln Pro Gln Leu Lys Ile
145                 150                 155                 160 
Asp Lys Ala Val Ala Phe Gln Asn Pro Gln Thr His Val Ile Glu Asn
                165                 170                 175     
Leu His Ala Ala Ala Tyr Arg Asn Ala Leu Ala Asn Pro Leu Tyr Cys
            180                 185                 190         
Pro Asp Tyr Arg Ile Gly Lys Val Thr Ser Glu Glu Leu His Tyr Phe
        195                 200                 205             
Val Gln Asn His Phe Thr Ser Ala Arg Met Ala Leu Ile Gly Leu Gly
    210                 215                 220                 
Val Ser His Pro Val Leu Lys Gln Val Ala Glu Gln Phe Leu Asn Met
225                 230                 235                 240 
Arg Gly Gly Leu Gly Leu Ser Gly Ala Lys Ala Asn Tyr Arg Gly Gly
                245                 250                 255     
Glu Ile Arg Glu Gln Asn Gly Asp Ser Leu Val His Ala Ala Phe Val
            260                 265                 270         
Ala Glu Ser Ala Val Ala Gly Ser Ala Glu Ala Asn Ala Phe Ser Val
        275                 280                 285             
Leu Gln His Val Leu Gly Ala Gly Pro His Val Lys Arg Gly Ser Asn
    290                 295                 300                 
Thr Thr Ser His Leu His Gln Ala Val Ala Lys Ala Thr Gln Gln Pro
305                 310                 315                 320 
Phe Asp Val Ser Ala Phe Asn Ala Ser Tyr Ser Asp Ser Gly Leu Phe
                325                 330                 335     
Gly Ile Tyr Thr Ile Ser Gln Ala Thr Ala Ala Gly Asp Val Ile Lys
            340                 345                 350         
Ala Ala Tyr Asn Gln Val Lys Thr Ile Ala Gln Gly Asn Leu Ser Asn
        355                 360                 365             
Thr Asp Val Gln Ala Ala Lys Asn Lys Leu Lys Ala Gly Tyr Leu Met
    370                 375                 380                 
Ser Val Glu Ser Ser Glu Cys Phe Leu Glu Glu Val Gly Ser Gln Ala
385                 390                 395                 400 
Leu Val Ala Gly Ser Tyr Met Pro Pro Ser Thr Val Leu Gln Gln Ile
                405                 410                 415     
Asp Ser Val Ala Asn Ala Asp Ile Ile Asn Ala Ala Lys Lys Phe Val
            420                 425                 430         
Ser Gly Gln Lys Ser Met Ala Ala Ser Gly Asn Leu Gly His Thr Pro
        435                 440                 445             
Phe Val Asp Glu Leu
    450             


<210> 2215
<211> 453
<212> PRT
<213> Homo sapiens

<400> 2215
Met Lys Leu Leu Thr Arg Ala Gly Ser Phe Ser Arg Phe Tyr Ser Leu
 1               5                  10                  15      
Lys Val Ala Pro Lys Val Lys Ala Thr Ala Ala Pro Ala Gly Ala Pro
            20                  25                  30          
Pro Gln Pro Gln Asp Leu Glu Phe Thr Lys Leu Pro Asn Gly Leu Val
        35                  40                  45              
Ile Ala Ser Leu Glu Asn Tyr Ser Pro Val Ser Arg Ile Gly Leu Phe
    50                  55                  60                  
Ile Lys Ala Gly Ser Arg Tyr Glu Asp Phe Ser Asn Leu Gly Thr Thr
65                  70                  75                  80  
His Leu Leu Arg Leu Thr Ser Ser Leu Thr Thr Lys Gly Ala Ser Ser
                85                  90                  95      
Phe Lys Ile Thr Arg Gly Ile Glu Ala Val Gly Gly Lys Leu Ser Val
            100                 105                 110         
Thr Ala Thr Arg Glu Asn Met Ala Tyr Thr Val Glu Cys Leu Arg Gly
        115                 120                 125             
Asp Val Asp Ile Leu Met Glu Phe Leu Leu Asn Val Thr Thr Ala Pro
    130                 135                 140                 
Glu Phe Arg Arg Trp Glu Val Ala Asp Leu Gln Pro Gln Leu Lys Ile
145                 150                 155                 160 
Asp Lys Ala Val Ala Phe Gln Asn Pro Gln Thr His Val Ile Glu Asn
                165                 170                 175     
Leu His Ala Ala Ala Tyr Arg Asn Ala Leu Ala Asn Pro Leu Tyr Cys
            180                 185                 190         
Pro Asp Tyr Arg Ile Gly Lys Val Thr Ser Glu Glu Leu His Tyr Phe
        195                 200                 205             
Val Gln Asn His Phe Thr Ser Ala Arg Met Ala Leu Ile Gly Leu Gly
    210                 215                 220                 
Val Ser His Pro Val Leu Lys Gln Val Ala Glu Gln Phe Leu Asn Met
225                 230                 235                 240 
Arg Gly Gly Leu Gly Leu Ser Gly Ala Lys Ala Asn Tyr Arg Gly Gly
                245                 250                 255     
Glu Ile Arg Glu Gln Asn Gly Asp Ser Leu Val His Ala Ala Phe Val
            260                 265                 270         
Ala Glu Ser Ala Val Ala Gly Ser Ala Glu Ala Asn Ala Phe Ser Val
        275                 280                 285             
Leu Gln His Val Leu Gly Ala Gly Pro His Val Lys Arg Gly Ser Asn
    290                 295                 300                 
Thr Thr Ser His Leu His Gln Ala Val Ala Lys Ala Thr Gln Gln Pro
305                 310                 315                 320 
Phe Asp Val Ser Ala Phe Asn Ala Ser Tyr Ser Asp Ser Gly Leu Phe
                325                 330                 335     
Gly Ile Tyr Thr Ile Ser Gln Ala Thr Ala Ala Gly Asp Val Ile Lys
            340                 345                 350         
Ala Ala Tyr Asn Gln Val Lys Thr Ile Ala Gln Gly Asn Leu Ser Asn
        355                 360                 365             
Thr Asp Val Gln Ala Ala Lys Asn Lys Leu Lys Ala Gly Tyr Leu Met
    370                 375                 380                 
Ser Val Glu Ser Ser Glu Cys Phe Leu Glu Glu Val Gly Ser Gln Ala
385                 390                 395                 400 
Leu Val Ala Gly Ser Tyr Met Pro Pro Ser Thr Val Leu Gln Gln Ile
                405                 410                 415     
Asp Ser Val Ala Asn Ala Asp Ile Ile Asn Ala Ala Lys Lys Phe Val
            420                 425                 430         
Ser Gly Gln Lys Ser Met Ala Ala Ser Gly Asn Leu Gly His Thr Pro
        435                 440                 445             
Phe Val Asp Glu Leu
    450             


<210> 2216
<211> 171
<212> PRT
<213> Homo sapiens

<400> 2216
Met Ala Ala Ala Ala Pro Asn Ala Gly Gly Ser Ala Pro Glu Thr Ala
 1               5                  10                  15      
Gly Ser Ala Glu Ala Pro Leu Gln Tyr Ser Leu Leu Leu Gln Tyr Leu
            20                  25                  30          
Val Gly Asp Lys Arg Gln Pro Arg Leu Leu Glu Pro Gly Ser Leu Gly
        35                  40                  45              
Gly Ile Pro Ser Pro Ala Lys Ser Glu Glu Gln Lys Met Ile Glu Lys
    50                  55                  60                  
Ala Met Glu Ser Cys Ala Phe Lys Ala Ala Leu Ala Cys Val Gly Gly
65                  70                  75                  80  
Phe Val Leu Gly Gly Ala Phe Gly Val Phe Thr Ala Gly Ile Asp Thr
                85                  90                  95      
Asn Val Gly Phe Asp Pro Lys Asp Pro Tyr Arg Thr Pro Thr Ala Lys
            100                 105                 110         
Glu Val Leu Lys Asp Met Gly Gln Arg Gly Met Ser Tyr Ala Lys Asn
        115                 120                 125             
Phe Ala Ile Val Gly Ala Met Phe Ser Cys Thr Glu Cys Leu Ile Glu
    130                 135                 140                 
Ser Tyr Arg Gly Thr Ser Asp Trp Lys Asn Ser Val Ile Ser Gly Cys
145                 150                 155                 160 
Ile Thr Gly Gly Ala Ile Gly Phe Arg Leu Ala
                165                 170     


<210> 2217
<211> 1966
<212> PRT
<213> Homo sapiens

<400> 2217
Met Ser Ser Ser Gly Tyr Pro Pro Asn Gln Gly Ala Phe Ser Thr Glu
 1               5                  10                  15      
Gln Ser Arg Tyr Pro Pro His Ser Val Gln Tyr Thr Phe Pro Asn Thr
            20                  25                  30          
Arg His Gln Gln Glu Phe Ala Val Pro Asp Tyr Arg Ser Ser His Leu
        35                  40                  45              
Glu Val Ser Gln Ala Ser Gln Leu Leu Gln Gln Gln Gln Gln Gln Gln
    50                  55                  60                  
Leu Arg Arg Arg Pro Ser Leu Leu Ser Glu Phe His Pro Gly Ser Asp
65                  70                  75                  80  
Arg Pro Gln Glu Arg Arg Thr Ser Tyr Glu Pro Phe His Pro Gly Pro
                85                  90                  95      
Ser Pro Val Asp His Asp Ser Leu Glu Ser Lys Arg Pro Arg Leu Glu
            100                 105                 110         
Gln Val Ser Asp Ser His Phe Gln Arg Val Ser Ala Ala Val Leu Pro
        115                 120                 125             
Leu Val His Pro Leu Pro Glu Gly Leu Arg Ala Ser Ala Asp Ala Lys
    130                 135                 140                 
Lys Asp Pro Ala Phe Gly Gly Lys His Glu Ala Pro Ser Ser Pro Ile
145                 150                 155                 160 
Ser Gly Gln Pro Cys Gly Asp Asp Gln Asn Ala Ser Pro Ser Lys Leu
                165                 170                 175     
Ser Lys Glu Glu Leu Ile Gln Ser Met Asp Arg Val Asp Arg Glu Ile
            180                 185                 190         
Ala Lys Val Glu Gln Gln Ile Leu Lys Leu Lys Lys Lys Gln Gln Gln
        195                 200                 205             
Leu Glu Glu Glu Ala Ala Lys Pro Pro Glu Pro Glu Lys Pro Val Ser
    210                 215                 220                 
Pro Pro Pro Val Glu Gln Lys His Arg Ser Ile Val Gln Ile Ile Tyr
225                 230                 235                 240 
Asp Glu Asn Arg Lys Lys Ala Glu Glu Ala His Lys Ile Phe Glu Gly
                245                 250                 255     
Leu Gly Pro Lys Val Glu Leu Pro Leu Tyr Asn Gln Pro Ser Asp Thr
            260                 265                 270         
Lys Val Tyr His Glu Asn Ile Lys Thr Asn Gln Val Met Arg Lys Lys
        275                 280                 285             
Leu Ile Leu Phe Phe Lys Arg Arg Asn His Ala Arg Lys Gln Arg Glu
    290                 295                 300                 
Gln Lys Ile Cys Gln Arg Tyr Asp Gln Leu Met Glu Ala Trp Glu Lys
305                 310                 315                 320 
Lys Val Asp Arg Ile Glu Asn Asn Pro Arg Arg Lys Ala Lys Glu Ser
                325                 330                 335     
Lys Thr Arg Glu Tyr Tyr Glu Lys Gln Phe Pro Glu Ile Arg Lys Gln
            340                 345                 350         
Arg Glu Gln Gln Glu Arg Phe Gln Arg Val Gly Gln Arg Gly Ala Gly
        355                 360                 365             
Leu Ser Ala Thr Ile Ala Arg Ser Glu His Glu Ile Ser Glu Ile Ile
    370                 375                 380                 
Asp Gly Leu Ser Glu Gln Glu Asn Asn Glu Lys Gln Met Arg Gln Leu
385                 390                 395                 400 
Ser Val Ile Pro Pro Met Met Phe Asp Ala Glu Gln Arg Arg Val Lys
                405                 410                 415     
Phe Ile Asn Met Asn Gly Leu Met Glu Asp Pro Met Lys Val Tyr Lys
            420                 425                 430         
Asp Arg Gln Phe Met Asn Val Trp Thr Asp His Glu Lys Glu Ile Phe
        435                 440                 445             
Lys Asp Lys Phe Ile Gln His Pro Lys Asn Phe Gly Leu Ile Ala Ser
    450                 455                 460                 
Tyr Leu Glu Arg Lys Ser Val Pro Asp Cys Val Leu Tyr Tyr Tyr Leu
465                 470                 475                 480 
Thr Lys Lys Asn Glu Asn Tyr Lys Ala Leu Val Arg Arg Asn Tyr Gly
                485                 490                 495     
Lys Arg Arg Gly Arg Asn Gln Gln Ile Ala Arg Pro Ser Gln Glu Glu
            500                 505                 510         
Lys Val Glu Glu Lys Glu Glu Asp Lys Ala Glu Lys Thr Glu Lys Lys
        515                 520                 525             
Glu Glu Glu Lys Lys Asp Glu Glu Glu Lys Asp Glu Lys Glu Asp Ser
    530                 535                 540                 
Lys Glu Asn Thr Lys Glu Lys Asp Lys Ile Asp Gly Thr Ala Glu Glu
545                 550                 555                 560 
Thr Glu Glu Arg Glu Gln Ala Thr Pro Arg Gly Arg Lys Thr Ala Asn
                565                 570                 575     
Ser Gln Gly Arg Arg Lys Gly Arg Ile Thr Arg Ser Met Thr Asn Glu
            580                 585                 590         
Ala Ala Ala Ala Ser Ala Ala Ala Ala Ala Ala Thr Glu Glu Pro Pro
        595                 600                 605             
Pro Pro Leu Pro Pro Pro Pro Glu Pro Ile Ser Thr Glu Pro Val Glu
    610                 615                 620                 
Thr Ser Arg Trp Thr Glu Glu Glu Met Glu Val Ala Lys Lys Gly Leu
625                 630                 635                 640 
Val Glu His Gly Arg Asn Trp Ala Ala Ile Ala Lys Met Val Gly Thr
                645                 650                 655     
Lys Ser Glu Ala Gln Cys Lys Asn Phe Tyr Phe Asn Tyr Lys Arg Arg
            660                 665                 670         
His Asn Leu Asp Asn Leu Leu Gln Gln His Lys Gln Lys Thr Ser Arg
        675                 680                 685             
Lys Pro Arg Glu Glu Arg Asp Val Ser Gln Cys Glu Ser Val Ala Ser
    690                 695                 700                 
Thr Val Ser Ala Gln Glu Asp Glu Asp Ile Glu Ala Ser Asn Glu Glu
705                 710                 715                 720 
Glu Asn Pro Glu Asp Ser Glu Val Glu Ala Val Lys Pro Ser Glu Asp
                725                 730                 735     
Ser Pro Glu Asn Ala Thr Ser Arg Gly Asn Thr Glu Pro Ala Val Glu
            740                 745                 750         
Leu Glu Pro Thr Thr Glu Thr Ala Pro Ser Thr Ser Pro Ser Leu Ala
        755                 760                 765             
Val Pro Ser Thr Lys Pro Ala Glu Asp Glu Ser Val Glu Thr Gln Val
    770                 775                 780                 
Asn Asp Ser Ile Ser Ala Glu Thr Ala Glu Gln Met Asp Val Asp Gln
785                 790                 795                 800 
Gln Glu His Ser Ala Glu Glu Gly Ser Val Cys Asp Pro Pro Pro Ala
                805                 810                 815     
Thr Lys Ala Asp Ser Val Asp Val Glu Val Arg Val Pro Glu Asn His
            820                 825                 830         
Ala Ser Lys Val Glu Gly Asp Asn Thr Lys Glu Arg Asp Leu Asp Arg
        835                 840                 845             
Ala Ser Glu Lys Val Glu Pro Arg Asp Glu Asp Leu Val Val Ala Gln
    850                 855                 860                 
Gln Ile Asn Ala Gln Arg Pro Glu Pro Gln Ser Asp Asn Asp Ser Ser
865                 870                 875                 880 
Ala Thr Cys Ser Ala Asp Glu Asp Val Asp Gly Glu Pro Glu Arg Gln
                885                 890                 895     
Arg Met Phe Pro Met Asp Ser Lys Pro Ser Leu Leu Asn Pro Thr Gly
            900                 905                 910         
Ser Ile Leu Val Ser Ser Pro Leu Lys Pro Asn Pro Leu Asp Leu Pro
        915                 920                 925             
Gln Leu Gln His Arg Ala Ala Val Ile Pro Pro Met Val Ser Cys Thr
    930                 935                 940                 
Pro Cys Asn Ile Pro Ile Gly Thr Pro Val Ser Gly Tyr Ala Leu Tyr
945                 950                 955                 960 
Gln Arg His Ile Lys Ala Met His Glu Ser Ala Leu Leu Glu Glu Gln
                965                 970                 975     
Arg Gln Arg Gln Glu Gln Ile Asp Leu Glu Cys Arg Ser Ser Thr Ser
            980                 985                 990         
Pro Cys Gly Thr Ser Lys Ser Pro Asn Arg Glu Trp Glu Val Leu Gln
        995                 1000                1005            
Pro Ala Pro His Gln Val Ile Thr Asn Leu Pro Glu Gly Val Arg Leu
    1010                1015                1020                
Pro Thr Thr Arg Pro Thr Arg Pro Pro Pro Pro Leu Ile Pro Ser Ser
1025                1030                1035                1040
Lys Thr Thr Val Ala Ser Glu Lys Pro Ser Phe Ile Met Gly Gly Ser
                1045                1050                1055    
Ile Ser Gln Gly Thr Pro Gly Thr Tyr Leu Thr Ser His Asn Gln Ala
            1060                1065                1070        
Ser Tyr Thr Gln Glu Thr Pro Lys Pro Ser Val Gly Ser Ile Ser Leu
        1075                1080                1085            
Gly Leu Pro Arg Gln Gln Glu Ser Ala Lys Ser Ala Thr Leu Pro Tyr
    1090                1095                1100                
Ile Lys Gln Glu Glu Phe Ser Pro Arg Ser Gln Asn Ser Gln Pro Glu
1105                1110                1115                1120
Gly Leu Leu Val Arg Ala Gln His Glu Gly Val Val Arg Gly Thr Ala
                1125                1130                1135    
Gly Ala Ile Gln Glu Gly Ser Ile Thr Arg Gly Thr Pro Thr Ser Lys
            1140                1145                1150        
Ile Ser Val Glu Ser Ile Pro Ser Leu Arg Gly Ser Ile Thr Gln Gly
        1155                1160                1165            
Thr Pro Ala Leu Pro Gln Thr Gly Ile Pro Thr Glu Ala Leu Val Lys
    1170                1175                1180                
Gly Ser Ile Ser Arg Met Pro Ile Glu Asp Ser Ser Pro Glu Lys Gly
1185                1190                1195                1200
Arg Glu Glu Ala Ala Ser Lys Gly His Val Ile Tyr Glu Gly Lys Ser
                1205                1210                1215    
Gly His Ile Leu Ser Tyr Asp Asn Ile Lys Asn Ala Arg Glu Gly Thr
            1220                1225                1230        
Arg Ser Pro Arg Thr Ala His Glu Ile Ser Leu Lys Arg Ser Tyr Glu
        1235                1240                1245            
Ser Val Glu Gly Asn Ile Lys Gln Gly Met Ser Met Arg Glu Ser Pro
    1250                1255                1260                
Val Ser Ala Pro Leu Glu Gly Leu Ile Cys Arg Ala Leu Pro Arg Gly
1265                1270                1275                1280
Ser Pro His Ser Asp Leu Lys Glu Arg Thr Val Leu Ser Gly Ser Ile
                1285                1290                1295    
Met Gln Gly Thr Pro Arg Ala Thr Thr Glu Ser Phe Glu Asp Gly Leu
            1300                1305                1310        
Lys Tyr Pro Lys Gln Ile Lys Arg Glu Ser Pro Pro Ile Arg Ala Phe
        1315                1320                1325            
Glu Gly Ala Ile Thr Lys Gly Lys Pro Tyr Asp Gly Ile Thr Thr Ile
    1330                1335                1340                
Lys Glu Met Gly Arg Ser Ile His Glu Ile Pro Arg Gln Asp Ile Leu
1345                1350                1355                1360
Thr Gln Glu Ser Arg Lys Thr Pro Glu Val Val Gln Ser Thr Arg Pro
                1365                1370                1375    
Ile Ile Glu Gly Ser Ile Ser Gln Gly Thr Pro Ile Lys Phe Asp Asn
            1380                1385                1390        
Asn Ser Gly Gln Ser Ala Ile Lys His Asn Val Lys Ser Leu Ile Thr
        1395                1400                1405            
Gly Pro Ser Lys Leu Ser Arg Gly Met Pro Pro Leu Glu Ile Val Pro
    1410                1415                1420                
Glu Asn Ile Lys Val Val Glu Arg Gly Lys Tyr Glu Asp Val Lys Ala
1425                1430                1435                1440
Gly Glu Thr Val Arg Ser Arg His Thr Ser Val Val Ser Ser Gly Pro
                1445                1450                1455    
Ser Val Leu Arg Ser Thr Leu His Glu Ala Pro Lys Ala Gln Leu Ser
            1460                1465                1470        
Pro Gly Ile Tyr Asp Asp Thr Ser Ala Arg Arg Thr Pro Val Ser Tyr
        1475                1480                1485            
Gln Asn Thr Met Ser Arg Gly Ser Pro Met Met Asn Arg Thr Ser Asp
    1490                1495                1500                
Val Thr Ile Ser Ser Asn Lys Ser Thr Asn His Glu Arg Lys Ser Thr
1505                1510                1515                1520
Leu Thr Pro Thr Gln Arg Glu Ser Ile Pro Ala Lys Ser Pro Val Pro
                1525                1530                1535    
Gly Val Asp Pro Val Val Ser His Ser Pro Phe Asp Pro His His Arg
            1540                1545                1550        
Gly Ser Thr Ala Gly Glu Val Tyr Arg Ser His Leu Pro Thr His Leu
        1555                1560                1565            
Asp Pro Ala Met Pro Phe His Arg Ala Leu Asp Pro Ala Ala Ala Ala
    1570                1575                1580                
Tyr Leu Phe Gln Arg Gln Leu Ser Pro Thr Pro Gly Tyr Pro Ser Gln
1585                1590                1595                1600
Tyr Gln Leu Tyr Ala Met Glu Asn Thr Arg Gln Thr Ile Leu Asn Asp
                1605                1610                1615    
Tyr Ile Thr Ser Gln Gln Met Gln Val Asn Leu Arg Pro Asp Val Ala
            1620                1625                1630        
Arg Gly Leu Ser Pro Arg Glu Gln Pro Leu Gly Leu Pro Tyr Pro Ala
        1635                1640                1645            
Thr Arg Gly Ile Ile Asp Leu Thr Asn Met Pro Pro Thr Ile Leu Val
    1650                1655                1660                
Pro His Pro Gly Gly Thr Ser Thr Pro Pro Met Asp Arg Ile Thr Tyr
1665                1670                1675                1680
Ile Pro Gly Thr Gln Ile Thr Phe Pro Pro Arg Pro Tyr Asn Ser Ala
                1685                1690                1695    
Ser Met Ser Pro Gly His Pro Thr His Leu Ala Ala Ala Ala Ser Ala
            1700                1705                1710        
Glu Arg Glu Arg Glu Arg Glu Arg Glu Lys Glu Arg Glu Arg Glu Arg
        1715                1720                1725            
Ile Ala Ala Ala Ser Ser Asp Leu Tyr Leu Arg Pro Gly Ser Glu Gln
    1730                1735                1740                
Pro Gly Arg Pro Gly Ser His Gly Tyr Val Arg Ser Pro Ser Pro Ser
1745                1750                1755                1760
Val Arg Thr Gln Glu Thr Met Leu Gln Gln Arg Pro Ser Val Phe Gln
                1765                1770                1775    
Gly Thr Asn Gly Thr Ser Val Ile Thr Pro Leu Asp Pro Thr Ala Gln
            1780                1785                1790        
Leu Arg Ile Met Pro Leu Pro Ala Gly Gly Pro Ser Ile Ser Gln Gly
        1795                1800                1805            
Leu Pro Ala Ser Arg Tyr Asn Thr Ala Ala Asp Ala Leu Ala Ala Leu
    1810                1815                1820                
Val Asp Ala Ala Ala Ser Ala Pro Gln Met Asp Val Ser Lys Thr Lys
1825                1830                1835                1840
Glu Ser Lys His Glu Ala Ala Arg Leu Glu Glu Asn Leu Arg Ser Arg
                1845                1850                1855    
Ser Ala Ala Val Ser Glu Gln Gln Gln Leu Glu Gln Lys Thr Leu Glu
            1860                1865                1870        
Val Glu Lys Arg Ser Val Gln Cys Leu Tyr Thr Ser Ser Ala Phe Pro
        1875                1880                1885            
Ser Gly Lys Pro Gln Pro His Ser Ser Val Val Tyr Ser Glu Ala Gly
    1890                1895                1900                
Lys Asp Lys Gly Pro Pro Pro Lys Ser Arg Tyr Glu Glu Glu Leu Arg
1905                1910                1915                1920
Thr Arg Gly Lys Thr Thr Ile Thr Ala Ala Asn Phe Ile Asp Val Ile
                1925                1930                1935    
Ile Thr Arg Gln Ile Ala Ser Asp Lys Asp Ala Arg Glu Arg Gly Ser
            1940                1945                1950        
Gln Ser Ser Asp Ser Ser Ser Ser Cys Ile Phe Ser Gln Val
        1955                1960                1965    


<210> 2218
<211> 246
<212> PRT
<213> Homo sapiens

<400> 2218
Met Asn Ser Ala Ala Val Leu Gly Thr Ser Pro Ser Ser Pro Thr Phe
 1               5                  10                  15      
Thr Phe Thr Leu Gly Arg His Tyr Ser Arg Asp Cys Ser Ser Ile Lys
            20                  25                  30          
Ala Gly Arg Arg Ser Ser Tyr Leu Leu Ala Ile Thr Thr Glu Arg Ser
        35                  40                  45              
Lys Ser Cys Asp Asp Gly Leu Asn Thr Phe Arg Asp Glu Gly Gln Val
    50                  55                  60                  
Leu Arg His Leu Pro Asn Arg Ile Pro Ser Leu Pro Leu Leu Arg Ser
65                  70                  75                  80  
Phe Phe Thr Asp Gly Ser Leu Asp Ser Trp Gly Thr Ser Glu Asp Ala
                85                  90                  95      
Asp Ala Pro Ser Lys Arg His Ser Thr Ser Asp Leu Ser Asp Ala Thr
            100                 105                 110         
Phe Ser Asn Ile Arg Arg Glu Asp Trp Leu Tyr Tyr Lys Gln Ile Leu
        115                 120                 125             
Thr Lys Lys Gly Lys Lys Ala Gly Ser Gly Leu Arg Gln Trp Lys Arg
    130                 135                 140                 
Val Tyr Ala Ala Leu Leu Ala Arg Ser Leu Ser Leu Ser Lys Glu Gln
145                 150                 155                 160 
Arg Glu Pro Gly Pro Ala Ala Ala Gly Ala Val Gly Ala Gly Ala Gly
                165                 170                 175     
Glu Asp Lys Ala Ala Pro Val Cys Ile Gly Ser Cys Leu Val Asp Ile
            180                 185                 190         
Tyr Ser Glu Thr Lys Arg Arg His Val Phe Arg Leu Thr Thr Ala Asp
        195                 200                 205             
Phe Cys Glu Tyr Leu Phe Gln Ala Glu Asp Arg Asp Asp Met Leu Gly
    210                 215                 220                 
Gly Ser Glu Arg Ser Gly Arg Thr Ala Gly Pro Arg Ala Arg Thr Pro
225                 230                 235                 240 
Ala Val Pro Thr Lys Leu
                245     


<210> 2219
<211> 247
<212> PRT
<213> Homo sapiens

<400> 2219
Met Ala Lys Thr Lys Lys Gly Lys Arg Leu Ser Thr Lys Gly Lys Arg
 1               5                  10                  15      
Arg Arg Arg Arg Leu Ser Leu Gly Ser Ser Gln Lys Thr Ser Leu Lys
            20                  25                  30          
Lys Lys Met Thr Arg Lys Ala Lys Arg Lys Ala Gly Thr Ser Gln Thr
        35                  40                  45              
Ser Ser Gln Met Arg Val Arg Thr Thr Glu Thr Ala Ala Trp Gly Ala
    50                  55                  60                  
Gly Ser Arg Trp Glu Arg Pro Ala Thr Cys Arg Gly Arg Thr Ala Ser
65                  70                  75                  80  
Arg Arg Arg Arg Lys Asp Gly Arg Pro Met Pro Pro Thr Asp Thr Gly
                85                  90                  95      
Ser Leu Leu Thr Ser Ser Thr Leu Arg Gly Arg Arg Thr Arg Ser Pro
            100                 105                 110         
Glu Thr Gly Glu Arg Thr Glu Gly Leu Pro Thr Arg Gly Glu Thr Lys
        115                 120                 125             
Lys Arg Lys Ser Leu Lys Ser Thr Arg Arg Arg Arg Ile Lys Ser Pro
    130                 135                 140                 
Gln Lys Ser Thr Arg Thr Gly Arg Thr Glu Pro Gln Trp Thr Pro Arg
145                 150                 155                 160 
Lys Ile Arg Lys Ile Asn Arg Ser Ser Pro Arg Arg Leu Lys Arg Ser
                165                 170                 175     
Thr Leu Pro Lys Thr Arg Leu Lys Ala Asn Thr Lys Arg Ser Arg Thr
            180                 185                 190         
Lys Asn Ile Pro Arg Arg Gly Ser Pro Arg Glu Val Pro Thr Arg Lys
        195                 200                 205             
Lys Ala Cys Leu Lys Ser Trp Lys Lys Arg Leu Ser Met Ser Thr Glu
    210                 215                 220                 
Lys Thr Pro Thr Ile Lys Ser Ala Arg Ser Pro Leu Thr Ala Ser Arg
225                 230                 235                 240 
Thr Glu Gly Arg Ser Arg Gly
                245         


<210> 2220
<211> 1704
<212> PRT
<213> Homo sapiens

<400> 2220
Met Ala Val Leu Arg Gln Leu Ala Leu Leu Leu Trp Lys Asn Tyr Thr
 1               5                  10                  15      
Leu Gln Lys Arg Lys Val Leu Val Thr Val Leu Glu Leu Phe Leu Pro
            20                  25                  30          
Leu Leu Phe Ser Gly Ile Leu Ile Trp Leu Arg Leu Lys Ile Gln Ser
        35                  40                  45              
Glu Asn Val Pro Asn Ala Thr Ile Tyr Pro Gly Gln Ser Ile Gln Glu
    50                  55                  60                  
Leu Pro Leu Phe Phe Thr Phe Pro Pro Pro Gly Asp Thr Trp Glu Leu
65                  70                  75                  80  
Ala Tyr Ile Pro Ser His Ser Asp Ala Ala Lys Thr Val Thr Glu Thr
                85                  90                  95      
Val Arg Arg Ala Leu Val Ile Asn Met Arg Val Arg Gly Phe Pro Ser
            100                 105                 110         
Glu Lys Asp Phe Glu Asp Tyr Ile Arg Tyr Asp Asn Cys Ser Ser Ser
        115                 120                 125             
Val Leu Ala Ala Val Val Phe Glu His Pro Phe Asn His Ser Lys Glu
    130                 135                 140                 
Pro Leu Pro Leu Ala Val Lys Tyr His Leu Arg Phe Ser Tyr Thr Arg
145                 150                 155                 160 
Arg Asn Tyr Met Trp Thr Gln Thr Gly Ser Phe Phe Leu Lys Glu Thr
                165                 170                 175     
Glu Gly Trp His Thr Thr Ser Leu Phe Pro Leu Phe Pro Asn Pro Gly
            180                 185                 190         
Pro Arg Glu Pro Thr Ser Pro Asp Gly Gly Glu Pro Gly Tyr Ile Arg
        195                 200                 205             
Glu Gly Phe Leu Ala Val Gln His Ala Val Asp Arg Ala Ile Met Glu
    210                 215                 220                 
Tyr His Ala Asp Ala Ala Thr Arg Gln Leu Phe Gln Arg Leu Thr Val
225                 230                 235                 240 
Thr Ile Lys Arg Phe Pro Tyr Pro Pro Phe Ile Ala Asp Pro Phe Leu
                245                 250                 255     
Val Ala Ile Gln Tyr Gln Leu Pro Leu Leu Leu Leu Leu Ser Phe Thr
            260                 265                 270         
Tyr Thr Ala Leu Thr Ile Ala Arg Ala Val Val Gln Glu Lys Glu Arg
        275                 280                 285             
Arg Leu Lys Glu Tyr Met Arg Met Met Gly Leu Ser Ser Trp Leu His
    290                 295                 300                 
Trp Ser Ala Trp Phe Leu Leu Phe Phe Leu Phe Leu Leu Ile Ala Ala
305                 310                 315                 320 
Ser Phe Met Thr Leu Leu Phe Cys Val Lys Val Lys Pro Asn Val Ala
                325                 330                 335     
Val Leu Ser Arg Ser Asp Pro Ser Leu Val Leu Ala Phe Leu Leu Cys
            340                 345                 350         
Phe Ala Ile Ser Thr Ile Ser Phe Ser Phe Met Val Ser Thr Phe Phe
        355                 360                 365             
Ser Lys Ala Asn Met Ala Ala Ala Phe Gly Gly Phe Leu Tyr Phe Phe
    370                 375                 380                 
Thr Tyr Ile Pro Tyr Phe Phe Val Ala Pro Arg Tyr Asn Trp Met Thr
385                 390                 395                 400 
Leu Ser Gln Lys Leu Cys Ser Cys Leu Leu Ser Asn Val Ala Met Ala
                405                 410                 415     
Met Gly Ala Gln Leu Ile Gly Lys Phe Glu Ala Lys Gly Met Gly Ile
            420                 425                 430         
Gln Trp Arg Asp Leu Leu Ser Pro Val Asn Val Asp Asp Asp Phe Cys
        435                 440                 445             
Phe Gly Gln Val Leu Gly Met Leu Leu Leu Asp Ser Val Leu Tyr Gly
    450                 455                 460                 
Leu Val Thr Trp Tyr Met Glu Ala Val Phe Pro Gly Gln Phe Gly Val
465                 470                 475                 480 
Pro Gln Pro Trp Tyr Phe Phe Ile Met Pro Ser Tyr Trp Cys Gly Lys
                485                 490                 495     
Pro Arg Ala Val Ala Gly Lys Glu Glu Glu Asp Ser Asp Pro Glu Lys
            500                 505                 510         
Ala Leu Arg Asn Glu Tyr Phe Glu Ala Glu Pro Glu Asp Leu Val Ala
        515                 520                 525             
Gly Ile Lys Ile Lys His Leu Ser Lys Val Phe Arg Val Gly Asn Lys
    530                 535                 540                 
Asp Arg Ala Ala Val Arg Asp Leu Asn Leu Asn Leu Tyr Glu Gly Gln
545                 550                 555                 560 
Ile Thr Val Leu Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu
                565                 570                 575     
Ser Met Leu Thr Gly Leu Phe Pro Pro Thr Ser Gly Arg Ala Tyr Ile
            580                 585                 590         
Ser Gly Tyr Glu Ile Ser Gln Asp Met Val Gln Ile Arg Lys Ser Leu
        595                 600                 605             
Gly Leu Cys Pro Gln His Asp Ile Leu Phe Asp Asn Leu Thr Val Ala
    610                 615                 620                 
Glu His Leu Tyr Phe Tyr Ala Gln Leu Lys Gly Leu Ser Arg Gln Lys
625                 630                 635                 640 
Cys Pro Glu Glu Val Lys Gln Met Leu His Ile Ile Gly Leu Glu Asp
                645                 650                 655     
Lys Trp Asn Ser Arg Ser Arg Phe Leu Ser Gly Gly Met Arg Arg Lys
            660                 665                 670         
Leu Ser Ile Gly Ile Ala Leu Ile Ala Gly Ser Lys Val Leu Ile Leu
        675                 680                 685             
Asp Glu Pro Thr Ser Gly Met Asp Ala Ile Ser Arg Arg Ala Ile Trp
    690                 695                 700                 
Asp Leu Leu Gln Arg Gln Lys Ser Asp Arg Thr Ile Val Leu Thr Thr
705                 710                 715                 720 
His Phe Met Asp Glu Ala Asp Leu Leu Gly Asp Arg Ile Ala Ile Met
                725                 730                 735     
Ala Lys Gly Glu Leu Gln Cys Cys Gly Ser Ser Leu Phe Leu Lys Gln
            740                 745                 750         
Lys Tyr Gly Ala Gly Tyr His Met Thr Leu Val Lys Glu Pro His Cys
        755                 760                 765             
Asn Pro Glu Asp Ile Ser Gln Leu Val His His His Val Pro Asn Ala
    770                 775                 780                 
Thr Leu Glu Ser Ser Ala Gly Ala Glu Leu Ser Phe Ile Leu Pro Arg
785                 790                 795                 800 
Glu Ser Thr His Arg Phe Glu Gly Leu Phe Ala Lys Leu Glu Lys Lys
                805                 810                 815     
Gln Lys Glu Leu Gly Ile Ala Ser Phe Gly Ala Ser Ile Thr Thr Met
            820                 825                 830         
Glu Glu Val Phe Leu Arg Val Gly Lys Leu Val Asp Ser Ser Met Asp
        835                 840                 845             
Ile Gln Ala Ile Gln Leu Pro Ala Leu Gln Tyr Gln His Glu Arg Arg
    850                 855                 860                 
Ala Ser Asp Trp Ala Val Asp Ser Asn Leu Cys Gly Ala Met Asp Pro
865                 870                 875                 880 
Ser Asp Gly Ile Gly Ala Leu Ile Glu Glu Glu Arg Thr Ala Val Lys
                885                 890                 895     
Leu Asn Thr Gly Leu Ala Leu His Cys Gln Gln Phe Trp Ala Met Phe
            900                 905                 910         
Leu Lys Lys Ala Ala Tyr Ser Trp Arg Glu Trp Lys Met Val Ala Ala
        915                 920                 925             
Gln Val Leu Val Pro Leu Thr Cys Val Thr Leu Ala Leu Leu Ala Ile
    930                 935                 940                 
Asn Tyr Ser Ser Glu Leu Phe Asp Asp Pro Met Leu Arg Leu Thr Leu
945                 950                 955                 960 
Gly Glu Tyr Gly Arg Thr Val Val Pro Phe Ser Val Pro Gly Thr Ser
                965                 970                 975     
Gln Leu Gly Gln Gln Leu Ser Glu His Leu Lys Asp Ala Leu Gln Ala
            980                 985                 990         
Glu Gly Gln Glu Pro Arg Glu Val Leu Gly Asp Leu Glu Glu Phe Leu
        995                 1000                1005            
Ile Phe Arg Ala Ser Val Glu Gly Gly Gly Phe Asn Glu Arg Cys Leu
    1010                1015                1020                
Val Ala Ala Ser Phe Arg Asp Val Gly Glu Arg Thr Val Val Asn Ala
1025                1030                1035                1040
Leu Phe Asn Asn Gln Ala Tyr His Ser Pro Ala Thr Ala Leu Ala Val
                1045                1050                1055    
Val Asp Asn Leu Leu Phe Lys Leu Leu Cys Gly Pro His Ala Ser Ile
            1060                1065                1070        
Val Val Ser Asn Phe Pro Gln Pro Arg Ser Ala Leu Gln Ala Ala Lys
        1075                1080                1085            
Asp Gln Phe Asn Glu Gly Arg Lys Gly Phe Asp Ile Ala Leu Asn Leu
    1090                1095                1100                
Leu Phe Ala Met Ala Phe Leu Ala Ser Thr Phe Ser Ile Leu Ala Val
1105                1110                1115                1120
Ser Glu Arg Ala Val Gln Ala Lys His Val Gln Phe Val Ser Gly Val
                1125                1130                1135    
His Val Ala Ser Phe Trp Leu Ser Ala Leu Leu Trp Asp Leu Ile Ser
            1140                1145                1150        
Phe Leu Ile Pro Ser Leu Leu Leu Leu Val Val Phe Lys Ala Phe Asp
        1155                1160                1165            
Val Arg Ala Phe Thr Arg Asp Gly His Met Ala Asp Thr Leu Leu Leu
    1170                1175                1180                
Leu Leu Leu Tyr Gly Trp Ala Ile Ile Pro Leu Met Tyr Leu Met Asn
1185                1190                1195                1200
Phe Phe Phe Leu Gly Ala Ala Thr Ala Tyr Thr Arg Leu Thr Ile Phe
                1205                1210                1215    
Asn Ile Leu Ser Gly Ile Ala Thr Phe Leu Met Val Thr Ile Met Arg
            1220                1225                1230        
Ile Pro Ala Val Lys Leu Glu Glu Leu Ser Lys Thr Leu Asp His Val
        1235                1240                1245            
Phe Leu Val Leu Pro Asn His Cys Leu Gly Met Ala Val Ser Ser Phe
    1250                1255                1260                
Tyr Glu Asn Tyr Glu Thr Arg Arg Tyr Cys Thr Ser Ser Glu Val Ala
1265                1270                1275                1280
Ala His Tyr Cys Lys Lys Tyr Asn Ile Gln Tyr Gln Glu Asn Phe Tyr
                1285                1290                1295    
Ala Trp Ser Ala Pro Gly Val Gly Arg Phe Val Ala Ser Met Ala Ala
            1300                1305                1310        
Ser Gly Cys Ala Tyr Leu Ile Leu Leu Phe Leu Ile Glu Thr Asn Leu
        1315                1320                1325            
Leu Gln Arg Leu Arg Gly Ile Leu Cys Ala Leu Arg Arg Arg Arg Thr
    1330                1335                1340                
Leu Thr Glu Leu Tyr Thr Arg Met Pro Val Leu Pro Glu Asp Gln Asp
1345                1350                1355                1360
Val Ala Asp Glu Arg Thr Arg Ile Leu Ala Pro Ser Pro Asp Ser Leu
                1365                1370                1375    
Leu His Thr Pro Leu Ile Ile Lys Glu Leu Ser Lys Val Tyr Glu Gln
            1380                1385                1390        
Arg Val Pro Leu Leu Ala Val Asp Arg Leu Ser Leu Ala Val Gln Lys
        1395                1400                1405            
Gly Glu Cys Phe Gly Leu Leu Gly Phe Asn Gly Ala Gly Lys Thr Thr
    1410                1415                1420                
Thr Phe Lys Met Leu Thr Gly Glu Glu Ser Leu Thr Ser Gly Asp Ala
1425                1430                1435                1440
Phe Val Gly Gly His Arg Ile Ser Ser Asp Val Gly Lys Val Arg Gln
                1445                1450                1455    
Arg Ile Gly Tyr Cys Pro Gln Phe Asp Ala Leu Leu Asp His Met Thr
            1460                1465                1470        
Gly Arg Glu Met Leu Val Met Tyr Ala Arg Leu Arg Gly Ile Pro Glu
        1475                1480                1485            
Arg His Ile Gly Ala Cys Val Glu Asn Thr Leu Arg Gly Leu Leu Leu
    1490                1495                1500                
Glu Pro His Ala Asn Lys Leu Val Arg Thr Tyr Ser Gly Gly Asn Lys
1505                1510                1515                1520
Arg Lys Leu Ser Thr Gly Ile Ala Leu Ile Gly Glu Pro Ala Val Ile
                1525                1530                1535    
Phe Leu Asp Glu Pro Ser Thr Gly Met Asp Pro Val Ala Arg Arg Leu
            1540                1545                1550        
Leu Trp Asp Thr Val Ala Arg Ala Arg Glu Ser Gly Lys Ala Ile Ile
        1555                1560                1565            
Ile Thr Ser His Ser Met Glu Glu Cys Glu Ala Leu Cys Thr Arg Leu
    1570                1575                1580                
Ala Ile Met Val Gln Gly Gln Phe Lys Cys Leu Gly Ser Pro Gln His
1585                1590                1595                1600
Leu Lys Ser Lys Phe Gly Ser Gly Tyr Ser Leu Arg Ala Lys Val Gln
                1605                1610                1615    
Ser Glu Gly Gln Gln Glu Ala Leu Glu Glu Phe Lys Ala Phe Val Asp
            1620                1625                1630        
Leu Thr Phe Pro Gly Ser Val Leu Glu Asp Glu His Gln Gly Met Val
        1635                1640                1645            
His Tyr His Leu Pro Gly Arg Asp Leu Ser Trp Ala Lys Val Phe Gly
    1650                1655                1660                
Ile Leu Glu Lys Ala Lys Glu Lys Tyr Gly Val Asp Asp Tyr Ser Val
1665                1670                1675                1680
Ser Gln Ile Ser Leu Glu Gln Val Phe Leu Ser Phe Ala His Leu Gln
                1685                1690                1695    
Pro Pro Thr Ala Glu Glu Gly Arg
            1700                


<210> 2221
<211> 423
<212> PRT
<213> Homo sapiens

<400> 2221
Met Ala Ala Trp Gly Cys Val Ala Ala Leu Gly Ala Ala Arg Gly Leu
 1               5                  10                  15      
Cys Trp Arg Ala Ala Arg Ala Ala Ala Gly Leu Gln Gly Arg Pro Ala
            20                  25                  30          
Arg Arg Cys Tyr Ala Val Gly Pro Ala Gln Ser Pro Pro Thr Phe Gly
        35                  40                  45              
Phe Leu Leu Asp Ile Asp Gly Val Leu Val Arg Gly His Arg Val Ile
    50                  55                  60                  
Pro Ala Ala Leu Lys Ala Phe Arg Arg Leu Val Asn Ser Gln Gly Gln
65                  70                  75                  80  
Leu Arg Val Pro Val Val Phe Val Thr Asn Ala Gly Asn Ile Leu Gln
                85                  90                  95      
His Ser Lys Ala Gln Glu Leu Ser Ala Leu Leu Gly Cys Glu Val Asp
            100                 105                 110         
Ala Asp Gln Val Ile Leu Ser His Ser Pro Met Lys Leu Phe Ser Glu
        115                 120                 125             
Tyr His Glu Lys Arg Met Leu Val Ser Gly Gln Gly Pro Val Met Glu
    130                 135                 140                 
Asn Ala Gln Gly Leu Gly Phe Arg Asn Val Val Thr Val Asp Glu Leu
145                 150                 155                 160 
Arg Met Ala Phe Pro Leu Leu Asp Met Val Asp Leu Glu Arg Arg Leu
                165                 170                 175     
Lys Thr Thr Pro Leu Pro Arg Asn Asp Phe Pro Arg Ile Glu Gly Val
            180                 185                 190         
Leu Leu Leu Gly Glu Pro Val Arg Trp Glu Thr Ser Leu Gln Leu Ile
        195                 200                 205             
Met Asp Val Leu Leu Ser Asn Gly Ser Pro Gly Ala Gly Leu Ala Thr
    210                 215                 220                 
Pro Pro Tyr Pro His Leu Pro Val Leu Ala Ser Asn Met Asp Leu Leu
225                 230                 235                 240 
Trp Met Ala Glu Ala Lys Met Pro Arg Phe Gly His Gly Thr Phe Leu
                245                 250                 255     
Leu Cys Leu Glu Thr Ile Tyr Gln Lys Val Thr Gly Lys Glu Leu Arg
            260                 265                 270         
Tyr Glu Gly Leu Met Gly Lys Pro Ser Ile Leu Thr Tyr Gln Tyr Ala
        275                 280                 285             
Glu Asp Leu Ile Arg Arg Gln Ala Glu Arg Arg Gly Trp Ala Ala Pro
    290                 295                 300                 
Ile Arg Lys Leu Tyr Ala Val Gly Asp Asn Pro Met Ser Asp Val Tyr
305                 310                 315                 320 
Gly Ala Asn Leu Phe His Gln Tyr Leu Gln Lys Ala Thr His Asp Gly
                325                 330                 335     
Ala Pro Glu Leu Gly Ala Gly Gly Thr Arg Gln Gln Gln Pro Ser Ala
            340                 345                 350         
Ser Gln Ser Cys Ile Ser Ile Leu Val Cys Thr Gly Val Tyr Asn Pro
        355                 360                 365             
Arg Asn Pro Gln Ser Thr Glu Pro Val Leu Gly Gly Gly Glu Pro Pro
    370                 375                 380                 
Phe His Gly His Arg Asp Leu Cys Phe Ser Pro Gly Leu Met Glu Ala
385                 390                 395                 400 
Ser His Val Val Asn Asp Val Asn Glu Ala Val Gln Leu Val Phe Arg
                405                 410                 415     
Lys Glu Gly Trp Ala Leu Glu
            420             


<210> 2222
<211> 139
<212> PRT
<213> Homo sapiens

<400> 2222
Met Ala Ala Ala Leu Ser Cys Ala Gly Pro Arg Leu Pro His His Pro
 1               5                  10                  15      
Pro Ser Asn Asn Arg Ser Trp Leu Trp Pro Arg Asn Lys Pro Ala Pro
            20                  25                  30          
Asn Leu Glu Ala Gly Thr Val Ala Cys Ser Val Gly Gln Gly Trp Ala
        35                  40                  45              
Gly Ser Ala Asp Ala Ser Ala Ala Gly Cys Ala Cys Val Pro Pro Ala
    50                  55                  60                  
Ser Val Ile Trp Gly Arg Trp Gly Leu Met Ser Ser Phe Met Ala Gly
65                  70                  75                  80  
Ala Val Lys Glu Thr Ala Ser Arg Val Gln Arg Pro Thr Gly Gln Pro
                85                  90                  95      
Arg Leu Glu His Val Val Gly Ser Gly Phe Gln Lys Ala Trp Arg Gly
            100                 105                 110         
Gln Ala Ser Ala Cys Val Thr Phe Gly Thr Ser Leu Leu Ala Lys Val
        115                 120                 125             
Pro His Glu Ala Lys Pro Arg Cys Gln Val Glu
    130                 135                 


<210> 2223
<211> 311
<212> PRT
<213> Homo sapiens

<400> 2223
Met Pro Ala Pro Arg Ala Pro Arg Ala Leu Ala Ala Ala Ala Pro Ala
 1               5                  10                  15      
Ser Gly Lys Ala Lys Leu Thr His Pro Gly Lys Ala Ile Leu Ala Gly
            20                  25                  30          
Gly Leu Ala Gly Gly Ile Glu Ile Cys Ile Thr Phe Pro Thr Glu Tyr
        35                  40                  45              
Val Lys Thr Gln Leu Gln Leu Asp Glu Arg Ser His Pro Pro Arg Tyr
    50                  55                  60                  
Arg Gly Ile Gly Asp Cys Val Arg Gln Thr Val Arg Ser His Gly Val
65                  70                  75                  80  
Leu Gly Leu Tyr Arg Gly Leu Ser Ser Leu Leu Tyr Gly Ser Ile Pro
                85                  90                  95      
Lys Ala Ala Val Arg Phe Gly Met Phe Glu Phe Leu Ser Asn His Met
            100                 105                 110         
Arg Asp Ala Gln Gly Arg Leu Asp Ser Thr Arg Gly Leu Leu Cys Gly
        115                 120                 125             
Leu Gly Ala Gly Val Ala Glu Ala Val Val Val Val Cys Pro Met Glu
    130                 135                 140                 
Thr Ile Lys Val Lys Phe Ile His Asp Gln Thr Ser Pro Asn Pro Lys
145                 150                 155                 160 
Tyr Arg Gly Phe Phe His Gly Val Arg Glu Ile Val Arg Glu Gln Gly
                165                 170                 175     
Leu Lys Gly Thr Tyr Gln Gly Leu Thr Ala Thr Val Leu Lys Gln Gly
            180                 185                 190         
Ser Asn Gln Ala Ile Arg Phe Phe Val Met Thr Ser Leu Arg Asn Trp
        195                 200                 205             
Tyr Arg Gly Asp Asn Pro Asn Lys Pro Met Asn Pro Leu Ile Thr Gly
    210                 215                 220                 
Val Phe Gly Ala Ile Ala Gly Ala Ala Ser Val Phe Gly Asn Thr Pro
225                 230                 235                 240 
Leu Asp Val Ile Lys Thr Arg Met Gln Gly Leu Glu Ala His Lys Tyr
                245                 250                 255     
Arg Asn Thr Trp Asp Cys Gly Leu Gln Ile Leu Lys Lys Glu Gly Leu
            260                 265                 270         
Lys Ala Phe Tyr Lys Gly Thr Val Pro Arg Leu Gly Arg Val Cys Leu
        275                 280                 285             
Asp Val Ala Ile Val Phe Val Ile Tyr Asp Glu Val Val Lys Leu Leu
    290                 295                 300                 
Asn Lys Val Trp Lys Thr Asp
305                 310     


<210> 2224
<211> 511
<212> PRT
<213> Homo sapiens

<400> 2224
Met Ala Ser Cys Pro Trp Gly Gln Glu Gln Gly Ala Arg Ser Pro Ser
 1               5                  10                  15      
Glu Glu Pro Pro Glu Glu Glu Ile Pro Lys Glu Asp Gly Ile Leu Val
            20                  25                  30          
Leu Ser Arg His Thr Leu Gly Leu Ala Leu Arg Glu His Pro Ala Leu
        35                  40                  45              
Leu Val Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Gln Ala Leu Ala
    50                  55                  60                  
Pro Glu Tyr Ser Lys Ala Ala Ala Val Leu Ala Ala Glu Ser Met Val
65                  70                  75                  80  
Val Thr Leu Ala Lys Val Asp Gly Pro Ala Gln Arg Glu Leu Ala Glu
                85                  90                  95      
Glu Phe Gly Val Thr Glu Tyr Pro Thr Leu Lys Phe Phe Arg Asn Gly
            100                 105                 110         
Asn Arg Thr His Pro Glu Glu Tyr Thr Gly Pro Arg Asp Ala Glu Gly
        115                 120                 125             
Ile Ala Glu Trp Leu Arg Arg Arg Val Gly Pro Ser Ala Met Arg Leu
    130                 135                 140                 
Glu Asp Glu Ala Ala Ala Gln Ala Leu Ile Gly Gly Arg Asp Leu Val
145                 150                 155                 160 
Val Ile Gly Phe Phe Gln Asp Leu Gln Asp Glu Asp Val Ala Thr Phe
                165                 170                 175     
Leu Ala Leu Ala Gln Asp Ala Leu Asp Met Thr Phe Gly Leu Thr Asp
            180                 185                 190         
Arg Pro Arg Leu Phe Gln Gln Phe Gly Leu Thr Lys Asp Thr Val Val
        195                 200                 205             
Leu Phe Lys Lys Phe Asp Glu Gly Arg Ala Asp Phe Pro Val Asp Glu
    210                 215                 220                 
Glu Leu Gly Leu Asp Leu Gly Asp Leu Ser Arg Phe Leu Val Thr His
225                 230                 235                 240 
Ser Met Arg Leu Val Thr Glu Phe Asn Ser Gln Thr Ser Ala Lys Ile
                245                 250                 255     
Phe Ala Ala Arg Ile Leu Asn His Leu Leu Leu Phe Val Asn Gln Thr
            260                 265                 270         
Leu Ala Ala His Arg Glu Leu Leu Ala Gly Phe Gly Glu Ala Ala Pro
        275                 280                 285             
Arg Phe Arg Gly Gln Val Leu Phe Val Val Val Asp Val Ala Ala Asp
    290                 295                 300                 
Asn Glu His Val Leu Gln Tyr Phe Gly Leu Lys Ala Glu Ala Ala Pro
305                 310                 315                 320 
Thr Leu Arg Leu Val Asn Leu Glu Thr Thr Lys Lys Tyr Ala Pro Val
                325                 330                 335     
Asp Gly Gly Pro Val Thr Ala Ala Ser Ile Thr Ala Phe Cys His Ala
            340                 345                 350         
Val Leu Asn Gly Gln Val Lys Pro Tyr Leu Leu Ser Gln Glu Ile Pro
        355                 360                 365             
Pro Asp Trp Asp Gln Arg Pro Val Lys Thr Leu Val Gly Lys Asn Phe
    370                 375                 380                 
Glu Gln Val Ala Phe Asp Glu Thr Lys Asn Val Phe Val Lys Phe Tyr
385                 390                 395                 400 
Ala Pro Trp Cys Thr His Cys Lys Glu Met Ala Pro Ala Trp Glu Ala
                405                 410                 415     
Leu Ala Glu Lys Tyr Gln Asp His Glu Asp Ile Ile Ile Ala Glu Leu
            420                 425                 430         
Asp Ala Thr Ala Asn Glu Leu Asp Ala Phe Ala Val His Gly Phe Pro
        435                 440                 445             
Thr Leu Lys Tyr Phe Pro Ala Gly Pro Gly Arg Lys Val Ile Glu Tyr
    450                 455                 460                 
Lys Ser Thr Arg Asp Leu Glu Thr Phe Ser Lys Phe Leu Asp Asn Gly
465                 470                 475                 480 
Gly Val Leu Pro Thr Glu Glu Pro Pro Glu Glu Pro Ala Ala Pro Phe
                485                 490                 495     
Pro Glu Pro Pro Ala Asn Ser Thr Met Gly Ser Lys Glu Glu Leu
            500                 505                 510     


<210> 2225
<211> 116
<212> PRT
<213> Homo sapiens

<400> 2225
Met Glu Gly Val Leu Lys Lys Thr Thr Gly Leu Val Gly Leu Ala Val
 1               5                  10                  15      
Cys Asn Thr Pro His Glu Arg Leu Arg Ile Leu Tyr Thr Lys Ile Leu
            20                  25                  30          
Asp Val Leu Glu Glu Ile Pro Lys Asn Ala Ala Tyr Arg Lys Tyr Thr
        35                  40                  45              
Glu Gln Ile Thr Asn Glu Lys Leu Ala Met Val Lys Ala Glu Pro Asp
    50                  55                  60                  
Val Lys Lys Leu Glu Asp Gln Leu Gln Gly Ser Gln Leu Glu Glu Val
65                  70                  75                  80  
Ile Leu Gln Ala Glu His Glu Leu Asn Leu Ala Arg Lys Met Arg Glu
                85                  90                  95      
Trp Lys Pro Trp Ala Pro Leu Val Glu Glu Pro Pro Ala Asp Gln Trp
            100                 105                 110         
Lys Trp Pro Ile
        115     


<210> 2226
<211> 2130
<212> PRT
<213> Homo sapiens

<400> 2226
Met Asp Gln Gly Pro Trp Arg Cys Val Ala His Ala Pro Arg Ala Pro
 1               5                  10                  15      
Pro Thr Glu Val Ala Met Asp Ala Leu Glu Ser Leu Leu Asp Glu Val
            20                  25                  30          
Ala Leu Glu Gly Leu Asp Gly Leu Cys Leu Pro Ala Leu Trp Ser Arg
        35                  40                  45              
Leu Glu Thr Arg Val Pro Pro Phe Pro Leu Pro Leu Glu Pro Cys Thr
    50                  55                  60                  
Gln Glu Phe Leu Trp Arg Ala Leu Ala Thr His Pro Gly Ile Ser Phe
65                  70                  75                  80  
Tyr Glu Glu Pro Arg Glu Arg Pro Asp Leu Gln Leu Gln Asp Arg Tyr
                85                  90                  95      
Glu Glu Ile Asp Leu Glu Thr Gly Ile Leu Glu Ser Arg Arg Asp Pro
            100                 105                 110         
Val Ala Leu Glu Asp Val Tyr Pro Ile His Met Ile Leu Glu Asn Lys
        115                 120                 125             
Asp Gly Ile Gln Gly Ser Cys Arg Tyr Phe Lys Glu Arg Lys Asn Ile
    130                 135                 140                 
Thr Asn Asp Ile Arg Thr Lys Ser Leu Gln Pro Arg Cys Thr Met Val
145                 150                 155                 160 
Glu Ala Phe Asp Arg Trp Gly Lys Lys Leu Ile Ile Val Ala Ser Gln
                165                 170                 175     
Ala Met Arg Tyr Arg Ala Leu Ile Gly Gln Glu Gly Asp Pro Asp Leu
            180                 185                 190         
Lys Leu Pro Asp Phe Ser Tyr Cys Ile Leu Glu Arg Leu Gly Arg Ser
        195                 200                 205             
Arg Trp Gln Gly Glu Leu Gln Arg Asp Leu His Thr Thr Ala Phe Lys
    210                 215                 220                 
Val Asp Ala Gly Lys Leu His Tyr His Arg Lys Ile Leu Asn Lys Asn
225                 230                 235                 240 
Gly Leu Ile Thr Met Gln Ser His Val Ile Arg Leu Pro Thr Gly Ala
                245                 250                 255     
Gln Gln His Ser Ile Leu Leu Leu Leu Asn Arg Phe His Val Asp Arg
            260                 265                 270         
Arg Ser Lys Tyr Asp Ile Leu Met Glu Lys Leu Ser Val Met Leu Ser
        275                 280                 285             
Thr Arg Thr Asn His Ile Glu Thr Leu Gly Lys Leu Arg Glu Glu Leu
    290                 295                 300                 
Gly Leu Cys Glu Arg Thr Phe Lys Arg Leu Tyr Gln Tyr Met Leu Asn
305                 310                 315                 320 
Ala Gly Leu Ala Lys Val Val Ser Leu Arg Leu Gln Glu Ile His Pro
                325                 330                 335     
Glu Cys Gly Pro Cys Lys Thr Lys Lys Gly Thr Asp Val Met Val Arg
            340                 345                 350         
Cys Leu Lys Leu Leu Lys Glu Phe Lys Arg Asn Asp His Asp Asp Asp
        355                 360                 365             
Glu Asp Glu Glu Val Ile Ser Lys Thr Val Pro Pro Val Asp Ile Val
    370                 375                 380                 
Phe Glu Arg Asp Met Leu Thr Gln Thr Tyr Asp Leu Ile Glu Arg Arg
385                 390                 395                 400 
Gly Thr Lys Gly Ile Ser Gln Ala Glu Ile Arg Val Ala Met Asn Val
                405                 410                 415     
Gly Lys Leu Glu Ala Arg Met Leu Cys Arg Leu Leu Gln Arg Phe Lys
            420                 425                 430         
Val Val Lys Gly Phe Met Glu Asp Glu Gly Arg Gln Arg Thr Thr Lys
        435                 440                 445             
Tyr Ile Ser Cys Val Phe Ala Glu Glu Ser Asp Leu Ser Arg Gln Tyr
    450                 455                 460                 
Gln Arg Glu Lys Ala Arg Ser Glu Leu Leu Thr Thr Val Ser Leu Ala
465                 470                 475                 480 
Ser Met Gln Glu Glu Ser Leu Leu Pro Glu Gly Glu Asp Thr Phe Leu
                485                 490                 495     
Ser Glu Ser Asp Ser Glu Glu Glu Arg Ser Ser Ser Lys Arg Arg Gly
            500                 505                 510         
Arg Gly Ser Gln Lys Asp Thr Arg Ala Ser Ala Asn Leu Arg Pro Lys
        515                 520                 525             
Thr Gln Pro His His Ser Thr Pro Thr Lys Gly Gly Trp Lys Val Val
    530                 535                 540                 
Asn Leu His Pro Leu Lys Lys Gln Pro Pro Ser Phe Pro Gly Ala Ala
545                 550                 555                 560 
Glu Glu Arg Ala Cys Gln Ser Leu Ala Ser Arg Asp Ser Leu Leu Asp
                565                 570                 575     
Thr Ser Ser Val Ser Glu Pro Asn Val Ser Phe Val Ser His Cys Ala
            580                 585                 590         
Asp Ser Asn Ser Gly Asp Ile Ala Val Ile Glu Glu Val Arg Met Glu
        595                 600                 605             
Asn Pro Lys Glu Ser Ser Ser Ser Leu Lys Thr Gly Arg His Ser Ser
    610                 615                 620                 
Gly Gln Asp Lys Pro His Glu Thr Tyr Arg Leu Leu Lys Arg Arg Asn
625                 630                 635                 640 
Leu Ile Ile Glu Ala Val Thr Asn Leu Arg Leu Ile Glu Ser Leu Phe
                645                 650                 655     
Thr Ile Gln Lys Met Ile Met Asp Gln Glu Lys Gln Glu Gly Val Ser
            660                 665                 670         
Thr Lys Cys Cys Lys Lys Ser Ile Val Arg Leu Val Arg Asn Leu Ser
        675                 680                 685             
Glu Glu Gly Leu Leu Arg Leu Tyr Arg Thr Thr Val Ile Gln Asp Gly
    690                 695                 700                 
Ile Lys Lys Lys Val Asp Leu Val Val His Pro Ser Met Asp Gln Asn
705                 710                 715                 720 
Asp Pro Leu Val Arg Ser Ala Ile Glu Gln Val Arg Phe Arg Ile Ser
                725                 730                 735     
Asn Ser Ser Thr Ala Asn Arg Val Lys Thr Ser Gln Pro Pro Val Pro
            740                 745                 750         
Gln Gly Glu Ala Glu Glu Asp Ser Gln Gly Lys Glu Gly Pro Ser Gly
        755                 760                 765             
Ser Gly Asp Ser Gln Leu Ser Ala Ser Ser Arg Ser Glu Ser Gly Arg
    770                 775                 780                 
Met Lys Lys Ser Asp Asn Lys Met Gly Ile Thr Pro Leu Arg Asn Tyr
785                 790                 795                 800 
His Pro Ile Val Val Pro Gly Leu Gly Arg Ser Leu Gly Phe Leu Pro
                805                 810                 815     
Lys Met Pro Arg Leu Arg Val Val His Met Phe Leu Trp Tyr Leu Ile
            820                 825                 830         
Tyr Gly His Pro Ala Ser Asn Thr Val Glu Lys Pro Ser Phe Ile Ser
        835                 840                 845             
Glu Arg Arg Thr Ile Lys Gln Glu Ser Gly Arg Ala Gly Val Arg Pro
    850                 855                 860                 
Ser Ser Ser Gly Ser Ala Trp Glu Ala Cys Ser Glu Ala Pro Ser Lys
865                 870                 875                 880 
Gly Ser Gln Asp Gly Val Thr Trp Glu Ala Glu Val Glu Leu Ala Thr
                885                 890                 895     
Glu Thr Val Tyr Val Asp Asp Ala Ser Trp Met Arg Tyr Ile Pro Pro
            900                 905                 910         
Ile Pro Val His Arg Asp Phe Gly Phe Gly Trp Ala Leu Val Ser Asp
        915                 920                 925             
Ile Leu Leu Cys Leu Pro Leu Ser Ile Phe Ile Gln Ile Val Gln Val
    930                 935                 940                 
Ser Tyr Lys Val Asp Asn Leu Glu Glu Phe Leu Asn Asp Pro Leu Lys
945                 950                 955                 960 
Lys His Thr Leu Ile Arg Phe Leu Pro Arg Pro Ile Arg Gln Gln Leu
                965                 970                 975     
Leu Tyr Lys Arg Arg Tyr Ile Phe Ser Val Val Glu Asn Leu Gln Arg
            980                 985                 990         
Leu Cys Tyr Met Gly Leu Leu Gln Phe Gly Pro Thr Glu Lys Phe Gln
        995                 1000                1005            
Asp Lys Asp Gln Val Phe Ile Phe Leu Lys Lys Asn Ala Val Ile Val
    1010                1015                1020                
Asp Thr Thr Ile Cys Asp Pro His Tyr Asn Leu Ala Arg Ser Ser Arg
1025                1030                1035                1040
Pro Phe Glu Arg Arg Leu Tyr Val Leu Asn Ser Met Gln Asp Val Glu
                1045                1050                1055    
Asn Tyr Trp Phe Asp Leu Gln Cys Val Cys Leu Asn Thr Pro Leu Gly
            1060                1065                1070        
Val Val Arg Cys Pro Arg Val Arg Lys Asn Ser Ser Thr Asp Gln Gly
        1075                1080                1085            
Ser Asp Glu Glu Gly Ser Leu Gln Lys Glu Gln Glu Ser Ala Met Asp
    1090                1095                1100                
Lys His Asn Leu Glu Arg Lys Cys Ala Met Leu Glu Tyr Thr Thr Gly
1105                1110                1115                1120
Ser Arg Glu Val Val Asp Glu Gly Leu Ile Pro Gly Asp Gly Leu Gly
                1125                1130                1135    
Ala Ala Gly Leu Asp Ser Ser Phe Tyr Gly His Leu Lys Arg Asn Trp
            1140                1145                1150        
Ile Trp Thr Ser Tyr Ile Ile Asn Gln Ala Lys Lys Glu Asn Thr Ala
        1155                1160                1165            
Ala Glu Asn Gly Leu Thr Val Arg Leu Gln Thr Phe Leu Ser Lys Arg
    1170                1175                1180                
Pro Met Pro Leu Ser Ala Arg Gly Asn Ser Arg Leu Asn Ile Trp Gly
1185                1190                1195                1200
Glu Ala Arg Val Gly Ser Glu Leu Cys Ala Gly Trp Glu Glu Gln Phe
                1205                1210                1215    
Glu Val Asp Arg Glu Pro Ser Leu Asp Arg Asn Arg Arg Val Arg Gly
            1220                1225                1230        
Gly Lys Ser Gln Lys Arg Lys Arg Leu Lys Lys Asp Pro Gly Lys Lys
        1235                1240                1245            
Ile Lys Arg Lys Lys Lys Gly Glu Phe Pro Gly Glu Lys Ser Lys Arg
    1250                1255                1260                
Leu Arg Tyr His Asp Glu Ala Asp Gln Ser Ala Leu Gln Arg Met Thr
1265                1270                1275                1280
Arg Leu Arg Val Thr Trp Ser Met Gln Glu Asp Gly Leu Leu Val Leu
                1285                1290                1295    
Cys Arg Ile Ala Ser Asn Val Leu Asn Thr Lys Val Lys Gly Pro Phe
            1300                1305                1310        
Val Thr Trp Gln Val Val Arg Asp Ile Leu His Ala Thr Phe Glu Glu
        1315                1320                1325            
Ser Leu Asp Lys Thr Ser His Ser Val Gly Arg Arg Ala Arg Tyr Ile
    1330                1335                1340                
Val Lys Asn Pro Gln Ala Tyr Leu Asn Tyr Lys Val Cys Leu Ala Glu
1345                1350                1355                1360
Val Tyr Gln Asp Lys Ala Leu Val Gly Asp Phe Met Asn Arg Arg Gly
                1365                1370                1375    
Asp Tyr Asp Asp Pro Lys Val Cys Ala Asn Glu Phe Lys Glu Phe Val
            1380                1385                1390        
Glu Lys Leu Lys Glu Lys Phe Ser Ser Ala Leu Arg Asn Ser Asn Leu
        1395                1400                1405            
Glu Ile Pro Asp Thr Leu Gln Glu Leu Phe Ala Arg Tyr Arg Val Leu
    1410                1415                1420                
Ala Ile Gly Asp Glu Lys Asp Gln Thr Arg Lys Glu Asp Glu Leu Asn
1425                1430                1435                1440
Ser Val Asp Asp Ile His Phe Leu Val Leu Gln Asn Leu Ile Gln Ser
                1445                1450                1455    
Thr Leu Ala Leu Ser Asp Ser Gln Met Lys Ser Tyr Gln Ser Phe Gln
            1460                1465                1470        
Thr Phe Arg Leu Tyr Arg Glu Tyr Lys Asp His Val Leu Val Lys Ala
        1475                1480                1485            
Phe Met Glu Cys Gln Lys Arg Ser Leu Val Asn Arg Arg Arg Val Asn
    1490                1495                1500                
His Thr Leu Gly Pro Lys Lys Asn Arg Ala Leu Pro Phe Val Pro Met
1505                1510                1515                1520
Ser Tyr Gln Leu Ser Gln Thr Tyr Tyr Arg Ile Phe Thr Trp Arg Phe
                1525                1530                1535    
Pro Ser Thr Ile Cys Thr Glu Ser Phe Gln Phe Leu Asp Arg Met Arg
            1540                1545                1550        
Ala Ala Gly Lys Leu Asp Gln Pro Asp Arg Phe Ser Phe Lys Asp Gln
        1555                1560                1565            
Asp Asn Asn Glu Pro Thr Asn Asp Met Val Ala Phe Ser Leu Asp Gly
    1570                1575                1580                
Pro Gly Gly Asn Cys Val Ala Val Leu Thr Leu Phe Ser Leu Gly Leu
1585                1590                1595                1600
Ile Ser Val Asp Val Arg Ile Pro Glu Gln Ile Ile Val Val Asp Ser
                1605                1610                1615    
Ser Met Val Glu Asn Glu Val Ile Lys Ser Leu Gly Lys Asp Gly Ser
            1620                1625                1630        
Leu Glu Asp Asp Glu Asp Glu Glu Asp Asp Leu Asp Glu Gly Val Gly
        1635                1640                1645            
Gly Lys Arg Arg Ser Met Glu Val Lys Pro Ala Gln Ala Ser His Thr
    1650                1655                1660                
Asn Tyr Leu Leu Met Arg Gly Tyr Tyr Ser Pro Gly Ile Val Ser Thr
1665                1670                1675                1680
Arg Asn Leu Asn Pro Asn Asp Ser Ile Val Val Asn Ser Cys Gln Met
                1685                1690                1695    
Lys Phe Gln Leu Arg Cys Thr Pro Val Pro Ala Arg Leu Arg Pro Ala
            1700                1705                1710        
Ala Ala Pro Leu Glu Glu Leu Thr Met Gly Thr Ser Cys Leu Pro Asp
        1715                1720                1725            
Thr Phe Thr Lys Leu Ile Asn Pro Gln Glu Asn Thr Cys Ser Leu Glu
    1730                1735                1740                
Glu Phe Val Leu Gln Leu Glu Leu Ser Gly Tyr Ser Pro Glu Asp Leu
1745                1750                1755                1760
Thr Ala Ala Leu Glu Ile Leu Glu Ala Ile Ile Ala Thr Gly Cys Phe
                1765                1770                1775    
Gly Ile Asp Lys Glu Glu Leu Arg Arg Arg Phe Ser Ala Leu Glu Lys
            1780                1785                1790        
Ala Gly Gly Gly Arg Thr Arg Thr Phe Ala Asp Cys Ile Gln Ala Leu
        1795                1800                1805            
Leu Glu Gln His Gln Val Leu Glu Val Gly Gly Asn Thr Ala Arg Leu
    1810                1815                1820                
Val Ala Met Gly Ser Ala Trp Pro Trp Leu Leu His Ser Val Arg Leu
1825                1830                1835                1840
Lys Asp Arg Glu Asp Ala Asp Ile Gln Arg Glu Asp Pro Gln Ala Arg
                1845                1850                1855    
Pro Leu Glu Gly Ser Ser Ser Glu Asp Ser Pro Pro Glu Gly Gln Ala
            1860                1865                1870        
Pro Pro Ser His Ser Pro Arg Gly Thr Lys Arg Arg Ala Ser Trp Ala
        1875                1880                1885            
Ser Glu Asn Gly Glu Thr Asp Ala Glu Gly Thr Gln Met Thr Pro Ala
    1890                1895                1900                
Lys Arg Pro Ala Leu Gln Asp Ser Asn Leu Ala Pro Ser Leu Gly Pro
1905                1910                1915                1920
Gly Ala Glu Asp Gly Ala Glu Ala Gln Ala Pro Ser Pro Pro Pro Ala
                1925                1930                1935    
Leu Glu Asp Thr Ala Ala Ala Gly Ala Ala Gln Glu Asp Gln Glu Gly
            1940                1945                1950        
Val Gly Glu Phe Ser Ser Pro Gly Gln Glu Gln Leu Ser Gly Gln Ala
        1955                1960                1965            
Gln Pro Pro Glu Gly Ser Glu Asp Pro Arg Gly Phe Thr Glu Ser Phe
    1970                1975                1980                
Gly Ala Ala Asn Ile Ser Gln Ala Ala Arg Glu Arg Asp Cys Glu Ser
1985                1990                1995                2000
Val Cys Phe Ile Gly Arg Pro Trp Arg Val Val Asp Gly His Leu Asn
                2005                2010                2015    
Leu Pro Val Cys Lys Gly Met Met Glu Ala Met Leu Tyr His Ile Met
            2020                2025                2030        
Thr Arg Pro Gly Ile Pro Glu Ser Ser Leu Leu Arg His Tyr Gln Gly
        2035                2040                2045            
Val Leu Gln Pro Val Ala Val Leu Glu Leu Leu Gln Gly Leu Glu Ser
    2050                2055                2060                
Leu Gly Cys Ile Arg Lys Arg Trp Leu Arg Lys Pro Arg Pro Val Ser
2065                2070                2075                2080
Leu Phe Ser Thr Pro Val Val Glu Glu Val Glu Val Pro Ser Ser Leu
                2085                2090                2095    
Asp Glu Ser Pro Met Ala Phe Tyr Glu Pro Thr Leu Asp Cys Thr Leu
            2100                2105                2110        
Arg Leu Gly Arg Val Phe Pro His Glu Val Asn Trp Asn Lys Trp Ile
        2115                2120                2125            
His Leu
    2130


<210> 2227
<211> 2044
<212> PRT
<213> Homo sapiens

<400> 2227
Met Cys Pro Val Asp Phe His Gly Ile Phe Gln Leu Asp Glu Arg Arg
 1               5                  10                  15      
Arg Asp Ala Val Ile Ala Leu Gly Ile Phe Leu Ile Glu Ser Asp Leu
            20                  25                  30          
Gln His Lys Asp Cys Val Val Pro Tyr Leu Leu Arg Leu Leu Lys Gly
        35                  40                  45              
Leu Pro Lys Val Tyr Trp Val Glu Glu Ser Thr Ala Arg Lys Gly Arg
    50                  55                  60                  
Gly Ala Leu Pro Val Ala Glu Ser Phe Ser Phe Cys Leu Val Thr Leu
65                  70                  75                  80  
Leu Ser Asp Val Ala Tyr Arg Asp Pro Ser Leu Arg Asp Glu Ile Leu
                85                  90                  95      
Glu Val Leu Leu Gln Val Leu His Val Leu Leu Gly Met Cys Gln Ala
            100                 105                 110         
Leu Glu Ile Gln Asp Lys Glu Tyr Leu Cys Lys Tyr Ala Ile Pro Cys
        115                 120                 125             
Leu Ile Gly Ile Ser Arg Ala Phe Gly Arg Tyr Ser Asn Met Glu Glu
    130                 135                 140                 
Ser Leu Leu Ser Lys Leu Phe Pro Lys Ile Pro Pro His Ser Leu Arg
145                 150                 155                 160 
Val Leu Glu Glu Leu Glu Gly Val Arg Arg Arg Ser Phe Asn Asp Phe
                165                 170                 175     
Arg Ser Ile Leu Pro Ser Asn Leu Leu Thr Val Cys Gln Glu Gly Thr
            180                 185                 190         
Leu Lys Arg Lys Thr Ser Ser Val Ser Ser Ile Ser Gln Val Ser Pro
        195                 200                 205             
Glu Arg Gly Met Pro Pro Pro Ser Ser Pro Gly Gly Ser Ala Phe His
    210                 215                 220                 
Tyr Phe Glu Ala Ser Cys Leu Pro Asp Gly Thr Ala Leu Glu Pro Glu
225                 230                 235                 240 
Tyr Tyr Phe Ser Thr Ile Ser Ser Ser Phe Ser Val Ser Pro Leu Phe
                245                 250                 255     
Asn Gly Val Thr Tyr Lys Glu Phe Asn Ile Pro Leu Glu Met Leu Arg
            260                 265                 270         
Glu Leu Leu Asn Leu Val Lys Lys Ile Val Glu Glu Ala Val Leu Lys
        275                 280                 285             
Ser Leu Asp Ala Ile Val Ala Ser Val Met Glu Ala Asn Pro Ser Ala
    290                 295                 300                 
Asp Leu Tyr Tyr Thr Ser Phe Ser Asp Pro Leu Tyr Leu Thr Met Phe
305                 310                 315                 320 
Lys Met Leu Arg Asp Thr Leu Tyr Tyr Met Lys Asp Leu Pro Thr Ser
                325                 330                 335     
Phe Val Lys Glu Ile His Asp Phe Val Leu Glu Gln Phe Asn Thr Ser
            340                 345                 350         
Gln Gly Glu Leu Gln Lys Ile Leu His Asp Ala Asp Arg Ile His Asn
        355                 360                 365             
Glu Leu Ser Pro Leu Lys Leu Arg Cys Gln Ala Asn Ala Ala Cys Val
    370                 375                 380                 
Asp Leu Met Val Trp Ala Val Lys Asp Glu Gln Gly Ala Glu Asn Leu
385                 390                 395                 400 
Cys Ile Lys Leu Ser Glu Lys Leu Gln Ser Lys Thr Ser Ser Lys Val
                405                 410                 415     
Ile Ile Ala His Leu Pro Leu Leu Ile Cys Cys Leu Gln Gly Leu Gly
            420                 425                 430         
Arg Leu Cys Glu Arg Phe Pro Val Val Val His Ser Val Thr Pro Ser
        435                 440                 445             
Leu Arg Asp Phe Leu Val Ile Pro Ser Pro Val Leu Val Lys Leu Tyr
    450                 455                 460                 
Lys Tyr His Ser Gln Tyr His Thr Val Ala Gly Asn Asp Ile Lys Ile
465                 470                 475                 480 
Ser Val Thr Asn Glu His Ser Glu Ser Thr Leu Asn Val Met Ser Gly
                485                 490                 495     
Lys Lys Ser Gln Pro Ser Met Tyr Glu Gln Leu Arg Asp Ile Ala Ile
            500                 505                 510         
Asp Asn Ile Cys Arg Cys Leu Lys Ala Gly Leu Thr Val Asp Pro Val
        515                 520                 525             
Ile Val Glu Ala Phe Leu Ala Ser Leu Ser Asn Arg Leu Tyr Ile Ser
    530                 535                 540                 
Gln Glu Ser Asp Lys Asp Ala His Leu Ile Pro Asp His Thr Ile Arg
545                 550                 555                 560 
Ala Leu Gly His Ile Ala Val Ala Leu Arg Asp Thr Pro Lys Val Met
                565                 570                 575     
Glu Pro Ile Leu Gln Ile Leu Gln Gln Lys Phe Cys Gln Pro Pro Ser
            580                 585                 590         
Pro Leu Asp Val Leu Ile Ile Asp Gln Leu Gly Cys Leu Val Ile Thr
        595                 600                 605             
Gly Asn Gln Tyr Ile Tyr Gln Glu Val Trp Asn Leu Phe Gln Gln Ile
    610                 615                 620                 
Ser Val Lys Ala Ser Ser Val Val Tyr Ser Ala Thr Lys Asp Tyr Lys
625                 630                 635                 640 
Asp His Gly Tyr Arg His Cys Ser Leu Ala Val Ile Asn Ala Leu Ala
                645                 650                 655     
Asn Ile Ala Ala Asn Ile Gln Asp Glu His Leu Val Asp Glu Leu Leu
            660                 665                 670         
Met Asn Leu Leu Glu Leu Phe Val Gln Leu Gly Leu Glu Gly Lys Arg
        675                 680                 685             
Ala Ser Glu Arg Ala Ser Glu Lys Gly Pro Ala Leu Lys Ala Ser Ser
    690                 695                 700                 
Ser Ala Gly Asn Leu Gly Val Leu Ile Pro Val Ile Ala Val Leu Thr
705                 710                 715                 720 
Arg Arg Leu Pro Pro Ile Lys Glu Ala Lys Pro Arg Leu Gln Lys Leu
                725                 730                 735     
Phe Arg Asp Phe Trp Leu Tyr Ser Val Leu Met Gly Phe Ala Val Glu
            740                 745                 750         
Gly Ser Gly Leu Trp Pro Glu Glu Trp Tyr Glu Gly Val Cys Glu Ile
        755                 760                 765             
Ala Thr Lys Ser Pro Leu Leu Thr Phe Pro Ser Lys Glu Pro Leu Arg
    770                 775                 780                 
Ser Val Leu Gln Tyr Asn Ser Ala Met Lys Asn Asp Thr Val Thr Pro
785                 790                 795                 800 
Ala Glu Leu Ser Glu Leu Arg Ser Thr Ile Ile Asn Leu Leu Asp Pro
                805                 810                 815     
Pro Pro Glu Val Ser Ala Leu Ile Asn Lys Leu Asp Phe Ala Met Ser
            820                 825                 830         
Thr Tyr Leu Leu Ser Val Tyr Arg Leu Glu Tyr Met Arg Val Leu Arg
        835                 840                 845             
Ser Thr Asp Pro Asp Arg Phe Gln Val Met Phe Cys Tyr Phe Glu Asp
    850                 855                 860                 
Lys Ala Ile Gln Lys Asp Lys Ser Gly Met Met Gln Cys Val Ile Ala
865                 870                 875                 880 
Val Ala Asp Lys Val Phe Asp Ala Phe Leu Asn Met Met Ala Asp Lys
                885                 890                 895     
Ala Lys Thr Lys Glu Asn Glu Glu Glu Leu Glu Arg His Ala Gln Phe
            900                 905                 910         
Leu Leu Val Asn Phe Asn His Ile His Lys Arg Ile Arg Arg Val Ala
        915                 920                 925             
Asp Lys Tyr Leu Ser Gly Leu Val Asp Lys Phe Pro His Leu Leu Trp
    930                 935                 940                 
Ser Gly Thr Val Leu Lys Thr Met Leu Asp Ile Leu Gln Thr Leu Ser
945                 950                 955                 960 
Leu Ser Leu Ser Ala Asp Ile His Lys Asp Gln Pro Tyr Tyr Asp Ile
                965                 970                 975     
Pro Asp Ala Pro Tyr Arg Ile Thr Val Pro Asp Thr Tyr Glu Ala Arg
            980                 985                 990         
Glu Ser Ile Val Lys Asp Phe Ala Ala Arg Cys Gly Met Ile Leu Gln
        995                 1000                1005            
Glu Ala Met Lys Trp Ala Pro Thr Val Thr Lys Ser His Leu Gln Glu
    1010                1015                1020                
Tyr Leu Asn Lys His Gln Asn Trp Val Ser Gly Leu Ser Gln His Thr
1025                1030                1035                1040
Gly Leu Ala Met Ala Thr Glu Ser Ile Leu His Phe Ala Gly Tyr Asn
                1045                1050                1055    
Lys Gln Asn Thr Thr Leu Gly Ala Thr Gln Leu Ser Glu Arg Pro Ala
            1060                1065                1070        
Cys Val Lys Lys Asp Tyr Ser Asn Phe Met Ala Ser Leu Asn Leu Arg
        1075                1080                1085            
Asn Arg Tyr Ala Gly Glu Val Tyr Gly Met Ile Arg Phe Ser Gly Thr
    1090                1095                1100                
Thr Gly Gln Met Ser Asp Leu Asn Lys Met Met Val Gln Asp Leu His
1105                1110                1115                1120
Ser Ala Leu Asp Arg Ser His Pro Gln His Tyr Thr Gln Ala Met Phe
                1125                1130                1135    
Lys Leu Thr Ala Met Leu Ile Ser Ser Lys Asp Cys Asp Pro Gln Leu
            1140                1145                1150        
Leu His His Leu Cys Trp Gly Pro Leu Arg Met Phe Asn Glu His Gly
        1155                1160                1165            
Met Glu Thr Ala Leu Ala Cys Trp Glu Trp Leu Leu Ala Gly Lys Asp
    1170                1175                1180                
Gly Val Glu Val Pro Phe Met Arg Glu Met Ala Gly Ala Trp His Met
1185                1190                1195                1200
Thr Val Glu Gln Lys Phe Gly Leu Phe Ser Ala Glu Ile Lys Glu Ala
                1205                1210                1215    
Asp Pro Leu Ala Ala Ser Glu Ala Ser Gln Pro Lys Pro Cys Pro Pro
            1220                1225                1230        
Glu Val Thr Pro His Tyr Ile Trp Ile Asp Phe Leu Val Gln Arg Phe
        1235                1240                1245            
Glu Ile Ala Lys Tyr Cys Ser Ser Asp Gln Val Glu Ile Phe Ser Ser
    1250                1255                1260                
Leu Leu Gln Arg Ser Met Ser Leu Asn Ile Gly Gly Ala Lys Gly Ser
1265                1270                1275                1280
Met Asn Arg His Val Ala Ala Ile Gly Pro Arg Phe Lys Leu Leu Thr
                1285                1290                1295    
Leu Gly Leu Ser Leu Leu His Ala Asp Val Val Pro Asn Ala Thr Ile
            1300                1305                1310        
Arg Asn Val Leu Arg Glu Lys Ile Tyr Ser Thr Ala Phe Asp Tyr Phe
        1315                1320                1325            
Ser Cys Pro Pro Lys Phe Pro Thr Gln Gly Glu Lys Arg Leu Arg Glu
    1330                1335                1340                
Asp Ile Ser Ile Met Ile Lys Phe Trp Thr Ala Met Phe Ser Asp Lys
1345                1350                1355                1360
Lys Tyr Leu Thr Ala Ser Gln Leu Val Pro Pro Asp Asn Gln Asp Thr
                1365                1370                1375    
Arg Ser Asn Leu Asp Ile Thr Val Gly Ser Arg Gln Gln Ala Thr Gln
            1380                1385                1390        
Gly Trp Ile Asn Thr Tyr Pro Leu Ser Ser Gly Met Ser Thr Ile Ser
        1395                1400                1405            
Lys Lys Ser Gly Met Ser Lys Lys Thr Asn Arg Gly Ser Gln Leu His
    1410                1415                1420                
Lys Tyr Tyr Met Lys Arg Arg Thr Leu Leu Leu Ser Leu Leu Ala Thr
1425                1430                1435                1440
Glu Ile Glu Arg Leu Ile Thr Trp Tyr Asn Pro Leu Ser Ala Pro Glu
                1445                1450                1455    
Leu Glu Leu Asp Gln Ala Gly Glu Asn Ser Val Ala Asn Trp Arg Ser
            1460                1465                1470        
Lys Tyr Ile Ser Leu Ser Glu Lys Gln Trp Lys Asp Asn Val Asn Leu
        1475                1480                1485            
Ala Trp Ser Ile Ser Pro Tyr Leu Ala Val Gln Leu Pro Ala Arg Phe
    1490                1495                1500                
Lys Asn Thr Glu Ala Ile Gly Asn Glu Val Thr Arg Leu Val Arg Leu
1505                1510                1515                1520
Asp Pro Gly Ala Val Ser Asp Val Pro Glu Ala Ile Lys Phe Leu Val
                1525                1530                1535    
Thr Trp His Thr Ile Asp Ala Asp Ala Pro Glu Leu Ser His Val Leu
            1540                1545                1550        
Cys Trp Ala Pro Thr Asp Pro Pro Thr Gly Leu Ser Tyr Phe Ser Ser
        1555                1560                1565            
Met Tyr Pro Pro His Pro Leu Thr Ala Gln Tyr Gly Val Lys Val Leu
    1570                1575                1580                
Arg Ser Phe Pro Pro Asp Ala Ile Leu Phe Tyr Ile Pro Gln Ile Val
1585                1590                1595                1600
Gln Ala Leu Arg Tyr Asp Lys Met Gly Tyr Val Arg Glu Tyr Ile Leu
                1605                1610                1615    
Trp Ala Ala Ser Lys Ser Gln Leu Leu Ala His Gln Phe Ile Trp Asn
            1620                1625                1630        
Met Lys Thr Asn Ile Tyr Leu Asp Glu Glu Gly His Gln Lys Asp Pro
        1635                1640                1645            
Asp Ile Gly Asp Leu Leu Asp Gln Leu Val Glu Glu Ile Thr Gly Ser
    1650                1655                1660                
Leu Ser Gly Pro Ala Lys Asp Phe Tyr Gln Arg Glu Phe Asp Phe Phe
1665                1670                1675                1680
Asn Lys Ile Thr Asn Val Ser Ala Ile Ile Lys Pro Tyr Pro Lys Gly
                1685                1690                1695    
Asp Glu Arg Lys Lys Ala Cys Leu Ser Ala Leu Ser Glu Val Lys Val
            1700                1705                1710        
Gln Pro Gly Cys Tyr Leu Pro Ser Asn Pro Glu Ala Ile Val Leu Asp
        1715                1720                1725            
Ile Asp Tyr Lys Ser Gly Thr Pro Met Gln Ser Ala Ala Lys Ala Pro
    1730                1735                1740                
Tyr Leu Ala Lys Phe Lys Val Lys Arg Cys Gly Val Ser Glu Leu Glu
1745                1750                1755                1760
Lys Glu Gly Leu Arg Cys Arg Ser Asp Ser Glu Asp Glu Cys Ser Thr
                1765                1770                1775    
Gln Glu Ala Asp Gly Gln Lys Ile Ser Trp Gln Ala Ala Ile Phe Lys
            1780                1785                1790        
Val Gly Asp Asp Cys Arg Gln Asp Met Leu Ala Leu Gln Ile Ile Asp
        1795                1800                1805            
Leu Phe Lys Asn Ile Phe Gln Leu Val Gly Leu Asp Leu Phe Val Phe
    1810                1815                1820                
Pro Tyr Arg Val Val Ala Thr Ala Pro Gly Cys Gly Val Ile Glu Cys
1825                1830                1835                1840
Ile Pro Asp Cys Thr Ser Arg Asp Gln Leu Gly Arg Gln Thr Asp Phe
                1845                1850                1855    
Gly Met Tyr Asp Tyr Phe Thr Arg Gln Tyr Gly Asp Glu Ser Thr Leu
            1860                1865                1870        
Ala Phe Gln Gln Ala Arg Tyr Asn Phe Ile Arg Ser Met Ala Ala Tyr
        1875                1880                1885            
Ser Leu Leu Leu Phe Leu Leu Gln Ile Lys Asp Arg His Asn Gly Asn
    1890                1895                1900                
Ile Met Leu Asp Lys Lys Gly His Ile Ile His Ile Asp Phe Gly Phe
1905                1910                1915                1920
Met Phe Glu Ser Ser Pro Gly Gly Asn Leu Gly Trp Glu Pro Asp Ile
                1925                1930                1935    
Lys Leu Thr Asp Glu Met Val Met Ile Met Gly Gly Lys Met Glu Ala
            1940                1945                1950        
Thr Pro Phe Lys Trp Phe Met Glu Met Cys Val Arg Gly Tyr Leu Ala
        1955                1960                1965            
Val Arg Pro Tyr Met Asp Ala Val Val Ser Leu Val Thr Leu Met Leu
    1970                1975                1980                
Asp Thr Gly Leu Pro Cys Phe Arg Gly Gln Thr Ile Lys Leu Leu Lys
1985                1990                1995                2000
His Arg Phe Ser Pro Asn Met Thr Glu Arg Glu Ala Ala Asn Phe Ile
                2005                2010                2015    
Met Lys Val Ile Gln Ser Cys Phe Leu Ser Asn Arg Ser Arg Thr Tyr
            2020                2025                2030        
Asp Met Ile Gln Tyr Tyr Gln Asn Asp Ile Pro Tyr
        2035                2040                


<210> 2228
<211> 2789
<212> PRT
<213> Homo sapiens

<400> 2228
Met Arg Leu Gly Gly Gly Gln Leu Val Ser Glu Glu Leu Met Asn Leu
 1               5                  10                  15      
Gly Glu Ser Phe Ile Gln Thr Asn Asp Pro Ser Leu Lys Leu Phe Gln
            20                  25                  30          
Cys Ala Val Cys Asn Lys Phe Thr Thr Asp Asn Leu Asp Met Leu Gly
        35                  40                  45              
Leu His Met Asn Val Glu Arg Ser Leu Ser Glu Asp Glu Trp Lys Ala
    50                  55                  60                  
Val Met Gly Asp Ser Tyr Gln Cys Lys Leu Cys Arg Tyr Asn Thr Gln
65                  70                  75                  80  
Leu Lys Ser Asn Phe Gln Leu His Cys Lys Thr Asp Lys His Val Gln
                85                  90                  95      
Lys Tyr Gln Leu Val Ala His Ile Lys Glu Gly Gly Lys Ala Asn Glu
            100                 105                 110         
Trp Arg Leu Lys Cys Val Ala Ile Gly Asn Pro Val His Leu Lys Cys
        115                 120                 125             
Asn Ala Cys Asp Tyr Tyr Thr Asn Ser Leu Glu Lys Leu Arg Leu His
    130                 135                 140                 
Thr Val Asn Ser Arg His Glu Ala Ser Leu Lys Leu Tyr Lys His Leu
145                 150                 155                 160 
Gln Gln His Glu Ser Gly Val Glu Gly Glu Ser Cys Tyr Tyr His Cys
                165                 170                 175     
Val Leu Cys Asn Tyr Ser Thr Lys Ala Lys Leu Asn Leu Ile Gln His
            180                 185                 190         
Val Arg Ser Met Lys His Gln Arg Ser Glu Ser Leu Arg Lys Leu Gln
        195                 200                 205             
Arg Leu Gln Lys Gly Leu Pro Glu Glu Asp Glu Asp Leu Gly Gln Ile
    210                 215                 220                 
Phe Thr Ile Arg Arg Cys Pro Ser Thr Asp Pro Glu Glu Ala Ile Glu
225                 230                 235                 240 
Asp Val Glu Gly Pro Ser Glu Thr Ala Ala Asp Pro Glu Glu Leu Ala
                245                 250                 255     
Lys Asp Gln Glu Gly Gly Ala Ser Ser Ser Gln Ala Glu Lys Glu Leu
            260                 265                 270         
Thr Asp Ser Pro Ala Thr Ser Lys Arg Ile Ser Phe Pro Gly Ser Ser
        275                 280                 285             
Glu Ser Pro Leu Ser Ser Lys Arg Pro Lys Thr Ala Glu Glu Ile Lys
    290                 295                 300                 
Pro Glu Gln Met Tyr Gln Cys Pro Tyr Cys Lys Tyr Ser Asn Ala Asp
305                 310                 315                 320 
Val Asn Arg Leu Arg Val His Ala Met Thr Gln His Ser Val Gln Pro
                325                 330                 335     
Met Leu Arg Cys Pro Leu Cys Gln Asp Met Leu Asn Asn Lys Ile His
            340                 345                 350         
Leu Gln Leu His Leu Thr His Leu His Ser Val Ala Pro Asp Cys Val
        355                 360                 365             
Glu Lys Leu Ile Met Thr Val Thr Thr Pro Glu Met Val Met Pro Ser
    370                 375                 380                 
Ser Met Phe Leu Pro Ala Ala Val Pro Asp Arg Asp Gly Asn Ser Asn
385                 390                 395                 400 
Leu Glu Glu Ala Gly Lys Gln Pro Glu Thr Ser Glu Asp Leu Gly Lys
                405                 410                 415     
Asn Ile Leu Pro Ser Ala Ser Thr Glu Gln Ser Gly Asp Leu Lys Pro
            420                 425                 430         
Ser Pro Ala Asp Pro Gly Ser Val Arg Glu Asp Ser Gly Phe Ile Cys
        435                 440                 445             
Trp Lys Lys Gly Cys Asn Gln Val Phe Lys Thr Ser Ala Ala Leu Gln
    450                 455                 460                 
Thr His Phe Asn Glu Val His Ala Lys Arg Pro Gln Leu Pro Val Ser
465                 470                 475                 480 
Asp Arg His Val Tyr Lys Tyr Arg Cys Asn Gln Cys Ser Leu Ala Phe
                485                 490                 495     
Lys Thr Ile Glu Lys Leu Gln Leu His Ser Gln Tyr His Val Ile Arg
            500                 505                 510         
Ala Ala Thr Met Cys Cys Leu Cys Gln Arg Ser Phe Arg Thr Phe Gln
        515                 520                 525             
Ala Leu Lys Lys His Leu Glu Thr Ser His Leu Glu Leu Ser Glu Ala
    530                 535                 540                 
Asp Ile Gln Gln Leu Tyr Gly Gly Leu Leu Ala Asn Gly Asp Leu Leu
545                 550                 555                 560 
Ala Met Gly Asp Pro Thr Leu Ala Glu Asp His Thr Ile Ile Val Glu
                565                 570                 575     
Glu Asp Lys Glu Glu Glu Ser Asp Leu Glu Asp Lys Gln Ser Pro Thr
            580                 585                 590         
Gly Ser Asp Ser Gly Ser Val Gln Glu Asp Ser Gly Ser Glu Pro Lys
        595                 600                 605             
Arg Ala Leu Pro Phe Arg Lys Gly Pro Asn Phe Thr Met Glu Lys Phe
    610                 615                 620                 
Leu Asp Pro Ser Arg Pro Tyr Lys Cys Thr Val Cys Lys Glu Ser Phe
625                 630                 635                 640 
Thr Gln Lys Asn Ile Leu Leu Val His Tyr Asn Ser Val Ser His Leu
                645                 650                 655     
His Lys Leu Lys Arg Ala Leu Gln Glu Ser Ala Thr Gly Gln Pro Glu
            660                 665                 670         
Pro Thr Ser Ser Pro Asp Asn Lys Pro Phe Lys Cys Asn Thr Cys Asn
        675                 680                 685             
Val Ala Tyr Ser Gln Ser Ser Thr Leu Glu Ile His Met Arg Ser Val
    690                 695                 700                 
Leu His Gln Thr Lys Ala Arg Ala Ala Lys Leu Glu Ala Ala Ser Gly
705                 710                 715                 720 
Ser Ser Asn Gly Thr Gly Asn Ser Ser Ser Ile Ser Leu Ser Ser Ser
                725                 730                 735     
Thr Pro Ser Pro Val Ser Thr Ser Gly Ser Asn Thr Phe Thr Thr Ser
            740                 745                 750         
Asn Pro Ser Ser Ala Gly Ile Ala Pro Ser Ser Asn Leu Leu Ser Gln
        755                 760                 765             
Val Pro Thr Glu Ser Val Gly Met Pro Pro Leu Gly Asn Pro Ile Gly
    770                 775                 780                 
Ala Asn Ile Ala Ser Pro Ser Glu Pro Lys Glu Ala Asn Arg Lys Lys
785                 790                 795                 800 
Leu Ala Asp Met Ile Ala Ser Arg Gln Gln Gln Gln Gln Gln Gln Gln
                805                 810                 815     
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Ala Gln Thr Leu Ala
            820                 825                 830         
Gln Ala Gln Ala Gln Val Gln Ala His Leu Gln Gln Glu Leu Gln Gln
        835                 840                 845             
Gln Ala Ala Leu Ile Gln Ser Gln Leu Phe Asn Pro Thr Leu Leu Pro
    850                 855                 860                 
His Phe Pro Met Thr Thr Glu Thr Leu Leu Gln Leu Gln Gln Gln Gln
865                 870                 875                 880 
His Leu Leu Phe Pro Phe Tyr Ile Pro Ser Ala Glu Phe Gln Leu Asn
                885                 890                 895     
Pro Glu Val Ser Leu Pro Val Thr Ser Gly Ala Leu Thr Leu Thr Gly
            900                 905                 910         
Thr Gly Pro Gly Leu Leu Glu Asp Leu Lys Ala Gln Val Gln Val Pro
        915                 920                 925             
Gln Gln Ser His Gln Gln Ile Leu Pro Gln Gln Gln Gln Asn Gln Leu
    930                 935                 940                 
Ser Ile Ala Gln Ser His Ser Ala Leu Leu Gln Pro Ser Gln His Pro
945                 950                 955                 960 
Glu Lys Lys Asn Lys Leu Val Ile Lys Glu Lys Glu Lys Glu Ser Gln
                965                 970                 975     
Arg Glu Arg Asp Ser Ala Glu Gly Gly Glu Gly Asn Thr Gly Pro Lys
            980                 985                 990         
Glu Thr Leu Pro Asp Ala Leu Lys Ala Lys Glu Lys Lys Glu Leu Ala
        995                 1000                1005            
Pro Gly Gly Gly Ser Glu Pro Ser Met Leu Pro Pro Arg Ile Ala Ser
    1010                1015                1020                
Asp Ala Arg Gly Asn Ala Thr Lys Ala Leu Leu Glu Asn Phe Gly Phe
1025                1030                1035                1040
Glu Leu Val Ile Gln Tyr Asn Glu Asn Lys Gln Lys Val Gln Lys Lys
                1045                1050                1055    
Asn Gly Lys Thr Asp Gln Gly Glu Asn Leu Glu Lys Leu Glu Cys Asp
            1060                1065                1070        
Ser Cys Gly Lys Leu Phe Ser Asn Ile Leu Ile Leu Lys Ser His Gln
        1075                1080                1085            
Glu His Val His Gln Asn Tyr Phe Pro Phe Lys Gln Leu Glu Arg Phe
    1090                1095                1100                
Ala Lys Gln Tyr Arg Asp His Tyr Asp Lys Leu Tyr Pro Leu Arg Pro
1105                1110                1115                1120
Gln Thr Pro Glu Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro
                1125                1130                1135    
Leu Pro Ala Ala Pro Pro Gln Pro Ala Ser Thr Pro Ala Ile Pro Ala
            1140                1145                1150        
Ser Ala Pro Pro Ile Thr Ser Pro Thr Ile Ala Pro Ala Gln Pro Ser
        1155                1160                1165            
Val Pro Leu Thr Gln Leu Ser Met Pro Met Glu Leu Pro Ile Phe Ser
    1170                1175                1180                
Pro Leu Met Met Gln Thr Met Pro Leu Gln Thr Leu Pro Ala Gln Leu
1185                1190                1195                1200
Pro Pro Gln Leu Gly Pro Val Glu Pro Leu Pro Ala Asp Leu Ala Gln
                1205                1210                1215    
Leu Tyr Gln His Gln Leu Asn Pro Thr Leu Leu Gln Gln Gln Asn Lys
            1220                1225                1230        
Arg Pro Arg Thr Arg Ile Thr Asp Asp Gln Leu Arg Val Leu Arg Gln
        1235                1240                1245            
Tyr Phe Asp Ile Asn Asn Ser Pro Ser Glu Glu Gln Ile Lys Glu Met
    1250                1255                1260                
Ala Asp Lys Ser Gly Leu Pro Gln Lys Val Ile Lys His Trp Phe Arg
1265                1270                1275                1280
Asn Thr Leu Phe Lys Glu Arg Gln Arg Asn Lys Asp Ser Pro Tyr Asn
                1285                1290                1295    
Phe Ser Asn Pro Pro Ile Thr Ser Leu Glu Glu Leu Lys Ile Asp Ser
            1300                1305                1310        
Arg Pro Pro Ser Pro Glu Pro Pro Lys Gln Glu Tyr Trp Gly Ser Lys
        1315                1320                1325            
Arg Ser Ser Arg Thr Arg Phe Thr Asp Tyr Gln Leu Arg Val Leu Gln
    1330                1335                1340                
Asp Phe Phe Asp Ala Asn Ala Tyr Pro Lys Asp Asp Glu Phe Glu Gln
1345                1350                1355                1360
Leu Ser Asn Leu Leu Asn Leu Pro Thr Arg Val Ile Val Val Trp Phe
                1365                1370                1375    
Gln Asn Ala Arg Gln Lys Ala Arg Lys Asn Tyr Glu Asn Gln Gly Glu
            1380                1385                1390        
Gly Lys Asp Gly Glu Arg Arg Glu Leu Thr Asn Asp Arg Tyr Ile Arg
        1395                1400                1405            
Thr Ser Asn Leu Asn Tyr Gln Cys Lys Lys Cys Ser Leu Val Phe Gln
    1410                1415                1420                
Arg Ile Phe Asp Leu Ile Lys His Gln Lys Lys Leu Cys Tyr Lys Asp
1425                1430                1435                1440
Glu Asp Glu Glu Gly Gln Asp Asp Ser Gln Asn Glu Asp Ser Met Asp
                1445                1450                1455    
Ala Met Glu Ile Leu Thr Pro Thr Ser Ser Ser Cys Ser Thr Pro Met
            1460                1465                1470        
Pro Ser Gln Ala Tyr Ser Ala Pro Ala Pro Ser Ala Asn Asn Thr Ala
        1475                1480                1485            
Ser Ser Ala Phe Leu Gln Leu Thr Ala Glu Ala Glu Glu Leu Ala Thr
    1490                1495                1500                
Phe Asn Ser Lys Thr Glu Ala Gly Asp Glu Lys Pro Lys Leu Ala Glu
1505                1510                1515                1520
Ala Pro Ser Ala Gln Pro Asn Gln Thr Gln Glu Lys Gln Gly Gln Pro
                1525                1530                1535    
Lys Pro Glu Leu Gln Gln Gln Glu Gln Pro Glu Gln Lys Thr Asn Thr
            1540                1545                1550        
Pro Gln Gln Lys Leu Pro Gln Leu Val Ser Leu Pro Ser Leu Pro Gln
        1555                1560                1565            
Pro Pro Pro Gln Ala Pro Pro Pro Gln Cys Pro Leu Pro Gln Ser Ser
    1570                1575                1580                
Pro Ser Pro Ser Gln Leu Ser His Leu Pro Leu Lys Pro Leu His Thr
1585                1590                1595                1600
Ser Thr Pro Gln Gln Leu Ala Asn Leu Pro Pro Gln Leu Ile Pro Tyr
                1605                1610                1615    
Gln Cys Asp Gln Cys Lys Leu Ala Phe Pro Ser Phe Glu His Trp Gln
            1620                1625                1630        
Glu His Gln Gln Leu His Phe Leu Ser Ala Gln Asn Gln Phe Ile His
        1635                1640                1645            
Pro Gln Phe Leu Asp Arg Ser Leu Asp Met Pro Phe Met Leu Phe Asp
    1650                1655                1660                
Pro Ser Asn Pro Leu Leu Ala Ser Gln Leu Leu Ser Gly Ala Ile Pro
1665                1670                1675                1680
Gln Ile Pro Ala Ser Ser Ala Thr Ser Pro Ser Thr Pro Thr Ser Thr
                1685                1690                1695    
Met Asn Thr Leu Lys Arg Lys Leu Glu Glu Lys Ala Ser Ala Ser Pro
            1700                1705                1710        
Gly Glu Asn Asp Ser Gly Thr Gly Gly Glu Glu Pro Gln Arg Asp Lys
        1715                1720                1725            
Arg Leu Arg Thr Thr Ile Thr Pro Glu Gln Leu Glu Ile Leu Tyr Gln
    1730                1735                1740                
Lys Tyr Leu Leu Asp Ser Asn Pro Thr Arg Lys Met Leu Asp His Ile
1745                1750                1755                1760
Ala His Glu Val Gly Leu Lys Lys Arg Val Val Gln Val Trp Phe Gln
                1765                1770                1775    
Asn Thr Arg Ala Arg Glu Arg Lys Gly Gln Phe Arg Ala Val Gly Pro
            1780                1785                1790        
Ala Gln Ala His Arg Arg Cys Pro Phe Cys Arg Ala Leu Phe Lys Ala
        1795                1800                1805            
Lys Thr Ala Leu Glu Ala His Ile Arg Ser Arg His Trp His Glu Ala
    1810                1815                1820                
Lys Arg Ala Gly Tyr Asn Leu Thr Leu Ser Ala Met Leu Leu Asp Cys
1825                1830                1835                1840
Asp Gly Gly Leu Gln Met Lys Gly Asp Ile Phe Asp Gly Thr Ser Phe
                1845                1850                1855    
Ser His Leu Pro Pro Ser Ser Ser Asp Gly Gln Gly Val Pro Leu Ser
            1860                1865                1870        
Pro Val Ser Lys Thr Met Glu Leu Ser Pro Arg Thr Leu Leu Ser Pro
        1875                1880                1885            
Ser Ser Ile Lys Val Glu Gly Ile Glu Asp Phe Glu Ser Pro Ser Met
    1890                1895                1900                
Ser Ser Val Asn Leu Asn Phe Asp Gln Thr Lys Leu Asp Asn Asp Asp
1905                1910                1915                1920
Cys Ser Ser Val Asn Thr Ala Ile Thr Asp Thr Thr Thr Gly Asp Glu
                1925                1930                1935    
Gly Asn Ala Asp Asn Asp Ser Ala Thr Gly Ile Ala Thr Glu Thr Lys
            1940                1945                1950        
Ser Ser Ser Ala Pro Asn Glu Gly Leu Thr Lys Ala Ala Met Met Ala
        1955                1960                1965            
Met Ser Glu Tyr Glu Asp Arg Leu Ser Ser Gly Leu Val Ser Pro Ala
    1970                1975                1980                
Pro Ser Phe Tyr Ser Lys Glu Tyr Asp Asn Glu Gly Thr Val Asp Tyr
1985                1990                1995                2000
Ser Glu Thr Ser Ser Leu Ala Asp Pro Cys Ser Pro Ser Pro Gly Ala
                2005                2010                2015    
Ser Gly Ser Ala Gly Lys Ser Gly Asp Ser Gly Asp Arg Pro Gly Gln
            2020                2025                2030        
Lys Arg Phe Arg Thr Gln Met Thr Asn Leu Gln Leu Lys Val Leu Lys
        2035                2040                2045            
Ser Cys Phe Asn Asp Tyr Arg Thr Pro Thr Met Leu Glu Cys Glu Val
    2050                2055                2060                
Leu Gly Asn Asp Ile Gly Leu Pro Lys Arg Val Val Gln Val Trp Phe
2065                2070                2075                2080
Gln Asn Ala Arg Ala Lys Glu Lys Lys Ser Lys Leu Ser Met Ala Lys
                2085                2090                2095    
His Phe Gly Ile Asn Gln Thr Ser Tyr Glu Gly Pro Lys Thr Glu Cys
            2100                2105                2110        
Thr Leu Cys Gly Ile Lys Tyr Ser Ala Arg Leu Ser Val Arg Asp His
        2115                2120                2125            
Ile Phe Ser Gln Gln His Ile Ser Lys Val Lys Asp Thr Ile Gly Ser
    2130                2135                2140                
Gln Leu Asp Lys Glu Lys Glu Tyr Phe Asp Pro Ala Thr Val Arg Gln
2145                2150                2155                2160
Leu Met Ala Gln Gln Glu Leu Asp Arg Ile Lys Lys Ala Asn Glu Val
                2165                2170                2175    
Leu Gly Leu Ala Ala Gln Gln Gln Gly Met Phe Asp Asn Thr Pro Leu
            2180                2185                2190        
Gln Ala Leu Asn Leu Pro Thr Ala Tyr Pro Ala Leu Gln Gly Ile Pro
        2195                2200                2205            
Pro Val Leu Leu Pro Gly Leu Asn Ser Pro Ser Leu Pro Gly Phe Thr
    2210                2215                2220                
Pro Ser Asn Thr Ala Leu Thr Ser Pro Lys Pro Asn Leu Met Gly Leu
2225                2230                2235                2240
Pro Ser Thr Thr Val Pro Ser Pro Gly Leu Pro Thr Ser Gly Leu Pro
                2245                2250                2255    
Asn Lys Pro Ser Ser Ala Ser Leu Ser Ser Pro Thr Pro Ala Gln Ala
            2260                2265                2270        
Thr Met Ala Met Gly Pro Gln Gln Pro Pro Gln Gln Gln Gln Gln Gln
        2275                2280                2285            
Gln Gln Pro Gln Val Gln Gln Pro Pro Pro Pro Pro Ala Ala Gln Pro
    2290                2295                2300                
Pro Pro Thr Pro Gln Leu Pro Leu Gln Gln Gln Gln Gln Arg Lys Asp
2305                2310                2315                2320
Lys Asp Ser Glu Lys Val Lys Glu Lys Glu Lys Ala His Lys Gly Lys
                2325                2330                2335    
Gly Glu Pro Leu Pro Val Pro Lys Lys Glu Lys Gly Glu Ala Pro Thr
            2340                2345                2350        
Ala Thr Ala Ala Thr Ile Ser Ala Pro Leu Pro Thr Met Glu Tyr Ala
        2355                2360                2365            
Val Asp Pro Ala Gln Leu Gln Ala Leu Gln Ala Ala Leu Thr Ser Asp
    2370                2375                2380                
Pro Thr Ala Leu Leu Thr Ser Gln Phe Leu Pro Tyr Phe Val Pro Gly
2385                2390                2395                2400
Phe Ser Pro Tyr Tyr Ala Pro Gln Ile Pro Gly Ala Leu Gln Ser Gly
                2405                2410                2415    
Tyr Leu Gln Pro Met Tyr Gly Met Glu Gly Leu Phe Pro Tyr Ser Pro
            2420                2425                2430        
Ala Leu Ser Gln Ala Leu Met Gly Leu Ser Pro Gly Ser Leu Leu Gln
        2435                2440                2445            
Gln Tyr Gln Gln Tyr Gln Gln Ser Leu Gln Glu Ala Ile Gln Gln Gln
    2450                2455                2460                
Gln Gln Arg Gln Leu Gln Gln Gln Gln Gln Gln Lys Val Gln Gln Gln
2465                2470                2475                2480
Gln Pro Lys Ala Ser Gln Thr Pro Val Pro Pro Gly Ala Pro Ser Pro
                2485                2490                2495    
Asp Lys Asp Pro Ala Lys Glu Ser Pro Lys Pro Glu Glu Gln Lys Asn
            2500                2505                2510        
Thr Pro Arg Glu Val Ser Pro Leu Leu Pro Lys Leu Pro Glu Glu Pro
        2515                2520                2525            
Glu Ala Glu Ser Lys Ser Ala Asp Ser Leu Tyr Asp Pro Phe Ile Val
    2530                2535                2540                
Pro Lys Val Gln Tyr Lys Leu Val Cys Arg Lys Cys Gln Ala Gly Phe
2545                2550                2555                2560
Ser Asp Glu Glu Ala Ala Arg Ser His Leu Lys Ser Leu Cys Phe Phe
                2565                2570                2575    
Gly Gln Ser Val Val Asn Leu Gln Glu Met Val Leu His Val Pro Thr
            2580                2585                2590        
Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly
        2595                2600                2605            
Gly Gly Gly Gly Gly Ser Tyr His Cys Leu Ala Cys Glu Ser Ala Leu
    2610                2615                2620                
Cys Gly Glu Glu Ala Leu Ser Gln His Leu Glu Ser Ala Leu His Lys
2625                2630                2635                2640
His Arg Thr Ile Thr Arg Ala Ala Arg Asn Ala Lys Glu His Pro Ser
                2645                2650                2655    
Leu Leu Pro His Ser Ala Cys Phe Pro Asp Pro Ser Thr Ala Ser Thr
            2660                2665                2670        
Ser Gln Ser Ala Ala His Ser Asn Asp Ser Pro Pro Pro Pro Ser Ala
        2675                2680                2685            
Ala Ala Pro Ser Ser Ala Ser Pro His Ala Ser Arg Lys Ser Trp Pro
    2690                2695                2700                
Gln Val Val Ser Arg Ala Ser Ala Ala Lys Pro Pro Ser Phe Pro Pro
2705                2710                2715                2720
Leu Ser Ser Ser Ser Thr Val Thr Ser Ser Ser Cys Ser Thr Ser Gly
                2725                2730                2735    
Val Gln Pro Ser Met Pro Thr Asp Asp Tyr Ser Glu Glu Ser Asp Thr
            2740                2745                2750        
Asp Leu Ser Gln Lys Ser Asp Gly Pro Ala Ser Pro Val Glu Gly Pro
        2755                2760                2765            
Lys Asp Pro Ser Cys Pro Lys Asp Ser Gly Leu Thr Ser Val Gly Thr
    2770                2775                2780                
Asp Thr Phe Arg Leu
2785                


<210> 2229
<211> 693
<212> PRT
<213> Homo sapiens

<400> 2229
Met Leu Asp Met Ser Val Pro Ala Val Ala Lys Leu Arg Arg Leu Leu
 1               5                  10                  15      
Asp Ser Leu Pro Arg Glu Ala Leu Pro Asp Ile Leu Thr Ser Ile Ile
            20                  25                  30          
Arg Thr Ser Asn Lys Glu Lys Leu Gln Ile Leu Asp Ala Val Ser Leu
        35                  40                  45              
Glu Glu Arg Phe Lys Met Thr Ile Pro Leu Leu Val Arg Gln Ile Glu
    50                  55                  60                  
Gly Leu Lys Leu Leu Gln Lys Thr Arg Lys Pro Lys Gln Asp Asp Asp
65                  70                  75                  80  
Lys Arg Val Ile Ala Ile Arg Pro Ile Arg Arg Ile Thr His Ile Ser
                85                  90                  95      
Gly Thr Leu Glu Asp Glu Asp Glu Asp Glu Asp Asn Asp Asp Ile Val
            100                 105                 110         
Met Leu Glu Lys Lys Ile Arg Thr Ser Ser Met Pro Glu Gln Ala His
        115                 120                 125             
Lys Val Cys Val Lys Glu Ile Lys Arg Leu Lys Lys Met Pro Gln Ser
    130                 135                 140                 
Met Pro Glu Tyr Ala Leu Thr Arg Asn Tyr Leu Glu Leu Met Val Glu
145                 150                 155                 160 
Leu Pro Trp Asn Lys Ser Thr Thr Asp Arg Leu Asp Ile Arg Ala Ala
                165                 170                 175     
Arg Ile Leu Leu Asp Asn Asp His Tyr Ala Met Glu Lys Leu Lys Lys
            180                 185                 190         
Arg Val Leu Glu Tyr Leu Ala Val Arg Gln Leu Lys Asn Asn Leu Lys
        195                 200                 205             
Gly Pro Ile Leu Cys Phe Val Gly Pro Pro Gly Val Gly Lys Thr Ser
    210                 215                 220                 
Val Gly Arg Ser Val Ala Lys Thr Leu Gly Arg Glu Phe His Arg Ile
225                 230                 235                 240 
Ala Leu Gly Gly Val Cys Asp Gln Ser Asp Ile Arg Gly His Arg Arg
                245                 250                 255     
Thr Tyr Val Gly Ser Met Pro Gly Arg Ile Ile Asn Gly Leu Lys Thr
            260                 265                 270         
Val Gly Val Asn Asn Pro Val Phe Leu Leu Asp Glu Val Asp Lys Leu
        275                 280                 285             
Gly Lys Ser Leu Gln Gly Asp Pro Ala Ala Ala Leu Leu Glu Val Leu
    290                 295                 300                 
Asp Pro Glu Gln Asn His Asn Phe Thr Asp His Tyr Leu Asn Val Ala
305                 310                 315                 320 
Phe Asp Leu Ser Gln Val Leu Phe Ile Ala Thr Ala Asn Thr Thr Ala
                325                 330                 335     
Thr Ile Pro Ala Ala Leu Leu Asp Arg Met Glu Ile Ile Gln Val Pro
            340                 345                 350         
Gly Tyr Thr Gln Glu Glu Lys Ile Glu Ile Ala His Arg His Leu Ile
        355                 360                 365             
Pro Lys Gln Leu Glu Gln His Gly Leu Thr Pro Gln Gln Ile Gln Ile
    370                 375                 380                 
Pro Gln Val Thr Thr Leu Asp Ile Ile Thr Arg Tyr Thr Arg Glu Ala
385                 390                 395                 400 
Gly Val Arg Ser Leu Asp Arg Lys Leu Gly Ala Ile Cys Arg Ala Val
                405                 410                 415     
Ala Val Lys Val Ala Glu Gly Gln His Lys Glu Ala Lys Leu Asp Arg
            420                 425                 430         
Ser Asp Val Thr Glu Arg Glu Gly Cys Arg Glu His Ile Leu Glu Asp
        435                 440                 445             
Glu Lys Pro Glu Ser Ile Ser Asp Thr Thr Asp Leu Ala Leu Pro Pro
    450                 455                 460                 
Glu Met Pro Ile Leu Ile Asp Phe His Ala Leu Lys Asp Ile Leu Gly
465                 470                 475                 480 
Pro Pro Met Tyr Glu Met Glu Val Ser Gln Arg Leu Ser Gln Pro Gly
                485                 490                 495     
Val Ala Ile Gly Leu Ala Trp Thr Pro Leu Gly Gly Glu Ile Met Phe
            500                 505                 510         
Val Glu Ala Ser Arg Met Asp Gly Glu Gly Gln Leu Thr Leu Thr Gly
        515                 520                 525             
Gln Leu Gly Asp Val Met Lys Glu Ser Ala His Leu Ala Ile Ser Trp
    530                 535                 540                 
Leu Arg Ser Asn Ala Lys Lys Tyr Gln Leu Thr Asn Ala Phe Gly Ser
545                 550                 555                 560 
Phe Asp Leu Leu Asp Asn Thr Asp Ile His Leu His Phe Pro Ala Gly
                565                 570                 575     
Ala Val Thr Lys Asp Gly Pro Ser Ala Gly Val Thr Ile Val Thr Cys
            580                 585                 590         
Leu Ala Ser Leu Phe Ser Gly Arg Leu Val Arg Ser Asp Val Ala Met
        595                 600                 605             
Thr Gly Glu Ile Thr Leu Arg Gly Leu Val Leu Pro Val Gly Gly Ile
    610                 615                 620                 
Lys Asp Lys Val Leu Ala Ala His Arg Ala Gly Leu Lys Gln Val Ile
625                 630                 635                 640 
Ile Pro Arg Arg Asn Glu Lys Asp Leu Glu Gly Ile Pro Gly Asn Val
                645                 650                 655     
Arg Gln Asp Leu Ser Phe Val Thr Ala Ser Cys Leu Asp Glu Val Leu
            660                 665                 670         
Asn Ala Ala Phe Asp Gly Gly Phe Thr Val Lys Thr Arg Pro Gly Leu
        675                 680                 685             
Leu Asn Ser Lys Leu
    690             


<210> 2230
<211> 952
<212> PRT
<213> Homo sapiens

<400> 2230
Met Ser Lys Ser Lys Ser Asp Asn Gln Ile Ser Asp Arg Ala Ala Leu
 1               5                  10                  15      
Glu Ala Lys Val Lys Asp Leu Leu Thr Leu Ala Lys Thr Lys Asp Val
            20                  25                  30          
Glu Ile Leu His Leu Arg Asn Glu Leu Arg Asp Met Arg Ala Gln Leu
        35                  40                  45              
Gly Ile Asn Glu Asp His Ser Glu Gly Asp Glu Lys Ser Glu Lys Glu
    50                  55                  60                  
Thr Ile Met Ala His Gln Pro Thr Asp Val Glu Ser Thr Leu Leu Gln
65                  70                  75                  80  
Leu Gln Glu Gln Asn Thr Ala Ile Arg Glu Glu Leu Asn Gln Leu Lys
                85                  90                  95      
Asn Glu Asn Arg Met Leu Lys Asp Arg Leu Asn Ala Leu Gly Phe Ser
            100                 105                 110         
Leu Glu Gln Arg Leu Asp Asn Ser Glu Lys Leu Phe Gly Tyr Gln Ser
        115                 120                 125             
Leu Ser Pro Glu Ile Thr Pro Asp Asn Gln Ser Asp Gly Gly Gly Thr
    130                 135                 140                 
Leu Thr Ser Ser Val Glu Gly Ser Ala Pro Gly Ser Val Glu Asp Leu
145                 150                 155                 160 
Leu Ser Gln Asp Glu Asn Thr Leu Met Asp His Gln His Ser Asn Ser
                165                 170                 175     
Met Asp Asn Leu Asp Ser Glu Cys Ser Glu Val Tyr Gln Pro Leu Thr
            180                 185                 190         
Ser Ser Asp Asp Ala Leu Asp Ala Pro Ser Ser Ser Glu Ser Glu Gly
        195                 200                 205             
Ile Pro Ser Ile Glu Arg Ser Arg Lys Gly Ser Ser Gly Asn Ala Ser
    210                 215                 220                 
Glu Val Ser Val Ala Cys Leu Thr Glu Arg Ile His Gln Met Glu Glu
225                 230                 235                 240 
Asn Gln His Ser Thr Ser Glu Glu Leu Gln Ala Thr Leu Gln Glu Leu
                245                 250                 255     
Ala Asp Leu Gln Gln Ile Thr Gln Glu Leu Asn Ser Glu Asn Glu Arg
            260                 265                 270         
Leu Gly Glu Glu Lys Val Ile Leu Met Glu Ser Leu Cys Gln Gln Ser
        275                 280                 285             
Asp Lys Leu Glu His Phe Ser Arg Gln Ile Glu Tyr Phe Arg Ser Leu
    290                 295                 300                 
Leu Asp Glu His His Ile Ser Tyr Val Ile Asp Glu Asp Val Lys Ser
305                 310                 315                 320 
Gly Arg Tyr Met Glu Leu Glu Gln Arg Tyr Met Asp Leu Ala Glu Asn
                325                 330                 335     
Ala Arg Phe Glu Arg Glu Gln Leu Leu Gly Val Gln Gln His Leu Ser
            340                 345                 350         
Asn Thr Leu Lys Met Ala Glu Gln Asp Asn Lys Glu Ala Gln Glu Met
        355                 360                 365             
Ile Gly Ala Leu Lys Glu Arg Ser His His Met Glu Arg Ile Ile Glu
    370                 375                 380                 
Ser Glu Gln Lys Gly Lys Ala Ala Leu Ala Ala Thr Leu Glu Glu Tyr
385                 390                 395                 400 
Lys Ala Thr Val Ala Ser Asp Gln Ile Glu Met Asn Arg Leu Lys Ala
                405                 410                 415     
Gln Leu Glu Asn Glu Lys Gln Lys Val Ala Glu Leu Tyr Ser Ile His
            420                 425                 430         
Asn Ser Gly Asp Lys Ser Asp Ile Gln Asp Leu Leu Glu Ser Val Arg
        435                 440                 445             
Leu Asp Lys Glu Lys Ala Glu Thr Leu Ala Ser Ser Leu Gln Glu Asp
    450                 455                 460                 
Leu Ala His Thr Arg Asn Asp Ala Asn Arg Leu Gln Asp Ala Ile Ala
465                 470                 475                 480 
Lys Val Glu Asp Glu Tyr Arg Ala Phe Gln Glu Glu Ala Lys Lys Gln
                485                 490                 495     
Ile Glu Asp Leu Asn Met Thr Leu Glu Lys Leu Arg Ser Asp Leu Asp
            500                 505                 510         
Glu Lys Glu Thr Glu Arg Ser Asp Met Lys Glu Thr Ile Phe Glu Leu
        515                 520                 525             
Glu Asp Glu Val Glu Gln His Arg Ala Val Lys Leu His Asp Asn Leu
    530                 535                 540                 
Ile Ile Ser Asp Leu Glu Asn Thr Val Lys Lys Leu Gln Asp Gln Lys
545                 550                 555                 560 
His Asp Met Glu Arg Glu Ile Lys Thr Leu His Arg Arg Leu Arg Glu
                565                 570                 575     
Glu Ser Ala Glu Trp Arg Gln Phe Gln Ala Asp Leu Gln Thr Ala Val
            580                 585                 590         
Val Ile Ala Asn Asp Ile Lys Ser Glu Ala Gln Glu Glu Ile Gly Asp
        595                 600                 605             
Leu Lys Arg Arg Leu His Glu Ala Gln Glu Lys Asn Glu Lys Leu Thr
    610                 615                 620                 
Lys Glu Leu Glu Glu Ile Lys Ser Arg Lys Gln Glu Glu Glu Arg Gly
625                 630                 635                 640 
Arg Val Tyr Asn Tyr Met Asn Ala Val Glu Arg Asp Leu Ala Ala Leu
                645                 650                 655     
Arg Gln Gly Met Gly Leu Ser Arg Arg Ser Ser Thr Ser Ser Glu Pro
            660                 665                 670         
Thr Pro Thr Val Lys Thr Leu Ile Lys Ser Phe Asp Ser Ala Ser Gln
        675                 680                 685             
Val Pro Asn Pro Ala Ala Ala Ala Ile Pro Arg Thr Pro Leu Ser Pro
    690                 695                 700                 
Ser Pro Met Lys Thr Pro Pro Ala Ala Ala Val Ser Pro Met Gln Arg
705                 710                 715                 720 
His Ser Ile Ser Gly Pro Ile Ser Thr Ser Lys Pro Leu Thr Ala Leu
                725                 730                 735     
Ser Asp Lys Arg Pro Asn Tyr Gly Glu Ile Pro Val Gln Glu His Leu
            740                 745                 750         
Leu Arg Thr Ser Ser Ala Ser Arg Pro Ala Ser Leu Pro Arg Val Pro
        755                 760                 765             
Ala Met Glu Ser Ala Lys Thr Leu Ser Val Ser Arg Arg Ser Ser Glu
    770                 775                 780                 
Glu Val Lys Arg Asp Ile Ser Ala Gln Glu Gly Ala Ser Pro Ala Ser
785                 790                 795                 800 
Leu Met Ala Met Gly Thr Thr Ser Pro Gln Leu Ser Leu Ser Ser Ser
                805                 810                 815     
Pro Thr Ala Ser Val Thr Pro Thr Thr Arg Ser Arg Ile Arg Glu Glu
            820                 825                 830         
Arg Lys Asp Pro Leu Ser Ala Leu Ala Arg Glu Tyr Gly Gly Ser Lys
        835                 840                 845             
Arg Asn Ala Leu Leu Lys Trp Cys Gln Lys Lys Thr Glu Gly Tyr Gln
    850                 855                 860                 
Asn Ile Asp Ile Thr Asn Phe Ser Ser Ser Trp Asn Asp Gly Leu Ala
865                 870                 875                 880 
Phe Cys Ala Leu Leu His Thr Tyr Leu Pro Ala His Ile Pro Tyr Gln
                885                 890                 895     
Glu Leu Asn Ser Gln Asp Lys Arg Arg Asn Phe Met Leu Ala Phe Gln
            900                 905                 910         
Ala Ala Glu Ser Val Gly Ile Lys Ser Thr Leu Asp Ile Asn Glu Met
        915                 920                 925             
Val Arg Thr Glu Arg Pro Asp Trp Gln Asn Val Met Leu Tyr Val Thr
    930                 935                 940                 
Ala Ile Tyr Lys Tyr Phe Glu Thr
945                 950         


<210> 2231
<211> 2263
<212> PRT
<213> Homo sapiens

<400> 2231
Met Tyr Asn Gly Ile Gly Leu Pro Thr Pro Arg Gly Ser Gly Thr Asn
 1               5                  10                  15      
Gly Tyr Val Gln Arg Asn Leu Ser Leu Val Arg Gly Arg Arg Gly Glu
            20                  25                  30          
Arg Pro Asp Tyr Lys Gly Glu Glu Glu Leu Arg Arg Leu Glu Ala Ala
        35                  40                  45              
Leu Val Lys Arg Pro Asn Pro Asp Ile Leu Asp His Glu Arg Lys Arg
    50                  55                  60                  
Arg Val Glu Leu Arg Cys Leu Glu Leu Glu Glu Met Met Glu Glu Gln
65                  70                  75                  80  
Gly Tyr Glu Glu Gln Gln Ile Gln Glu Lys Val Ala Thr Phe Arg Leu
                85                  90                  95      
Met Leu Leu Glu Lys Asp Val Asn Pro Gly Gly Lys Glu Glu Thr Pro
            100                 105                 110         
Gly Gln Arg Pro Ala Val Thr Glu Thr His Gln Leu Ala Glu Leu Asn
        115                 120                 125             
Glu Lys Lys Asn Glu Arg Leu Arg Ala Ala Phe Gly Ile Ser Asp Ser
    130                 135                 140                 
Tyr Val Asp Gly Ser Ser Phe Asp Pro Gln Arg Arg Ala Arg Glu Ala
145                 150                 155                 160 
Lys Gln Pro Ala Pro Glu Pro Pro Lys Pro Tyr Ser Leu Val Arg Glu
                165                 170                 175     
Ser Ser Ser Ser Arg Ser Pro Thr Pro Lys Gln Lys Lys Lys Lys Lys
            180                 185                 190         
Lys Lys Asp Arg Gly Arg Arg Ser Glu Ser Ser Ser Pro Arg Arg Glu
        195                 200                 205             
Arg Lys Lys Ser Ser Lys Lys Lys Lys His Arg Ser Glu Ser Glu Ser
    210                 215                 220                 
Lys Lys Arg Lys His Arg Ser Pro Thr Pro Lys Ser Lys Arg Lys Ser
225                 230                 235                 240 
Lys Asp Lys Lys Arg Lys Arg Ser Arg Ser Thr Thr Pro Ala Pro Lys
                245                 250                 255     
Ser Arg Arg Ala His Arg Ser Thr Ser Ala Asp Ser Ala Ser Ser Ser
            260                 265                 270         
Asp Thr Ser Arg Ser Arg Ser Arg Ser Ala Ala Ala Lys Thr His Thr
        275                 280                 285             
Thr Ala Leu Ala Gly Arg Ser Pro Ser Pro Ala Ser Gly Arg Arg Gly
    290                 295                 300                 
Glu Gly Asp Ala Pro Phe Ser Glu Pro Gly Thr Thr Ser Thr Gln Arg
305                 310                 315                 320 
Pro Ser Ser Pro Glu Thr Ala Thr Lys Gln Pro Ser Ser Pro Tyr Glu
                325                 330                 335     
Asp Lys Asp Lys Asp Lys Lys Glu Lys Ser Ala Thr Arg Pro Ser Pro
            340                 345                 350         
Ser Pro Glu Arg Ser Ser Thr Gly Pro Glu Pro Pro Ala Pro Thr Pro
        355                 360                 365             
Leu Leu Ala Glu Arg His Gly Gly Ser Pro Gln Pro Leu Ala Thr Thr
    370                 375                 380                 
Pro Leu Ser Gln Glu Pro Val Asn Pro Pro Ser Glu Ala Ser Pro Thr
385                 390                 395                 400 
Arg Asp Arg Ser Pro Pro Lys Ser Pro Glu Lys Leu Pro Gln Ser Ser
                405                 410                 415     
Ser Ser Glu Ser Ser Pro Pro Ser Pro Gln Pro Thr Lys Val Ser Arg
            420                 425                 430         
His Ala Ser Ser Ser Pro Glu Ser Pro Lys Pro Ala Pro Ala Pro Gly
        435                 440                 445             
Ser His Arg Glu Ile Ser Ser Ser Pro Thr Ser Lys Asn Arg Ser His
    450                 455                 460                 
Gly Arg Ala Lys Arg Asp Lys Ser His Ser His Thr Pro Ser Arg Arg
465                 470                 475                 480 
Met Gly Arg Ser Arg Ser Pro Ala Thr Ala Lys Arg Gly Arg Ser Arg
                485                 490                 495     
Ser Arg Thr Pro Thr Lys Arg Gly His Ser Arg Ser Arg Ser Pro Gln
            500                 505                 510         
Trp Arg Arg Ser Arg Ser Ala Gln Arg Trp Gly Arg Ser Arg Ser Pro
        515                 520                 525             
Gln Arg Arg Gly Arg Ser Arg Ser Pro Gln Arg Pro Gly Trp Ser Arg
    530                 535                 540                 
Ser Arg Asn Thr Gln Arg Arg Gly Arg Ser Arg Ser Ala Arg Arg Gly
545                 550                 555                 560 
Arg Ser His Ser Arg Ser Pro Ala Thr Arg Gly Arg Ser Arg Ser Arg
                565                 570                 575     
Thr Pro Ala Arg Arg Gly Arg Ser Arg Ser Arg Thr Pro Ala Arg Arg
            580                 585                 590         
Arg Ser Arg Ser Arg Thr Pro Thr Arg Arg Arg Ser Arg Ser Arg Thr
        595                 600                 605             
Pro Ala Arg Arg Gly Arg Ser Arg Ser Arg Thr Pro Ala Arg Arg Arg
    610                 615                 620                 
Ser Arg Thr Arg Ser Pro Val Arg Arg Arg Ser Arg Ser Arg Ser Pro
625                 630                 635                 640 
Ala Arg Arg Ser Gly Arg Ser Arg Ser Arg Thr Pro Ala Arg Arg Gly
                645                 650                 655     
Arg Ser Arg Ser Arg Thr Pro Ala Arg Arg Gly Arg Ser Arg Ser Arg
            660                 665                 670         
Thr Pro Ala Arg Arg Ser Gly Arg Ser Arg Ser Arg Thr Pro Ala Arg
        675                 680                 685             
Arg Gly Arg Ser Arg Ser Arg Thr Pro Arg Arg Gly Arg Ser Arg Ser
    690                 695                 700                 
Arg Ser Leu Val Arg Arg Gly Arg Ser His Ser Arg Thr Pro Gln Arg
705                 710                 715                 720 
Arg Gly Arg Ser Gly Ser Ser Ser Glu Arg Lys Asn Lys Ser Arg Thr
                725                 730                 735     
Ser Gln Arg Arg Ser Arg Ser Asn Ser Ser Pro Glu Met Lys Lys Ser
            740                 745                 750         
Arg Ile Ser Ser Arg Arg Ser Arg Ser Leu Ser Ser Pro Arg Ser Lys
        755                 760                 765             
Ala Lys Ser Arg Leu Ser Leu Arg Arg Ser Leu Ser Gly Ser Ser Pro
    770                 775                 780                 
Cys Pro Lys Gln Lys Ser Gln Thr Pro Pro Arg Arg Ser Arg Ser Gly
785                 790                 795                 800 
Ser Ser Gln Thr Lys Ala Lys Ser Arg Thr Pro Pro Arg Arg Ser Arg
                805                 810                 815     
Ser Ser Ser Ser Pro Pro Pro Lys Gln Lys Ser Lys Thr Pro Ser Arg
            820                 825                 830         
Gln Ser His Ser Ser Ser Ser Pro His Pro Lys Val Lys Ser Gly Thr
        835                 840                 845             
Pro Pro Arg Gln Gly Ser Ile Thr Ser Pro Gln Ala Asn Glu Gln Ser
    850                 855                 860                 
Val Thr Pro Gln Arg Arg Ser Cys Phe Glu Ser Ser Pro Asp Pro Glu
865                 870                 875                 880 
Leu Lys Ser Arg Thr Pro Ser Arg His Ser Cys Ser Gly Ser Ser Pro
                885                 890                 895     
Pro Arg Val Lys Ser Ser Thr Pro Pro Arg Gln Ser Pro Ser Arg Ser
            900                 905                 910         
Ser Ser Pro Gln Pro Lys Val Lys Ala Ile Ile Ser Pro Arg Gln Arg
        915                 920                 925             
Ser His Ser Gly Ser Ser Ser Pro Ser Pro Ser Arg Val Thr Ser Arg
    930                 935                 940                 
Thr Thr Pro Arg Arg Ser Arg Ser Val Ser Pro Cys Ser Asn Val Glu
945                 950                 955                 960 
Ser Arg Leu Leu Pro Arg Tyr Ser His Ser Gly Ser Ser Ser Pro Asp
                965                 970                 975     
Thr Lys Val Lys Pro Glu Thr Pro Pro Arg Gln Ser His Ser Gly Ser
            980                 985                 990         
Ile Ser Pro Tyr Pro Lys Val Lys Ala Gln Thr Pro Pro Gly Pro Ser
        995                 1000                1005            
Leu Ser Gly Ser Lys Ser Pro Cys Pro Gln Glu Lys Ser Lys Asp Ser
    1010                1015                1020                
Leu Val Gln Ser Cys Pro Gly Ser Leu Ser Leu Cys Ala Gly Val Lys
1025                1030                1035                1040
Ser Ser Thr Pro Pro Gly Glu Ser Tyr Phe Gly Val Ser Ser Leu Gln
                1045                1050                1055    
Leu Lys Gly Gln Ser Gln Thr Ser Pro Asp His Arg Ser Asp Thr Ser
            1060                1065                1070        
Ser Pro Glu Val Arg Gln Ser His Ser Glu Ser Pro Ser Leu Gln Ser
        1075                1080                1085            
Lys Ser Gln Thr Ser Pro Lys Gly Gly Arg Ser Arg Ser Ser Ser Pro
    1090                1095                1100                
Val Thr Glu Leu Ala Ser Arg Ser Pro Ile Arg Gln Asp Arg Gly Glu
1105                1110                1115                1120
Phe Ser Ala Ser Pro Met Leu Lys Ser Gly Met Ser Pro Glu Gln Ser
                1125                1130                1135    
Arg Phe Gln Ser Asp Ser Ser Ser Tyr Pro Thr Val Asp Ser Asn Ser
            1140                1145                1150        
Leu Leu Gly Gln Ser Arg Leu Glu Thr Ala Glu Ser Lys Glu Lys Met
        1155                1160                1165            
Ala Leu Pro Pro Gln Glu Asp Ala Thr Ala Ser Pro Pro Arg Gln Lys
    1170                1175                1180                
Asp Lys Phe Ser Pro Phe Pro Val Gln Asp Arg Pro Glu Ser Ser Leu
1185                1190                1195                1200
Val Phe Lys Asp Thr Leu Arg Thr Pro Pro Arg Glu Arg Ser Gly Ala
                1205                1210                1215    
Gly Ser Ser Pro Glu Thr Lys Glu Gln Asn Ser Ala Leu Pro Thr Ser
            1220                1225                1230        
Ser Gln Asp Glu Glu Leu Met Glu Val Val Glu Lys Ser Glu Glu Pro
        1235                1240                1245            
Ala Gly Gln Ile Leu Ser His Leu Ser Ser Glu Leu Lys Glu Met Ser
    1250                1255                1260                
Thr Ser Asn Phe Glu Ser Ser Pro Glu Val Glu Glu Arg Pro Ala Val
1265                1270                1275                1280
Ser Leu Thr Leu Asp Gln Ser Gln Ser Gln Ala Ser Leu Glu Ala Val
                1285                1290                1295    
Glu Val Pro Ser Met Ala Ser Ser Trp Gly Gly Pro His Phe Ser Pro
            1300                1305                1310        
Glu His Lys Glu Leu Ser Asn Ser Pro Leu Arg Glu Asn Ser Phe Gly
        1315                1320                1325            
Ser Pro Leu Glu Phe Arg Asn Ser Gly Pro Leu Gly Thr Glu Met Asn
    1330                1335                1340                
Thr Gly Phe Ser Ser Glu Val Lys Glu Asp Leu Asn Gly Pro Phe Leu
1345                1350                1355                1360
Asn Gln Leu Glu Thr Asp Pro Ser Leu Asp Met Lys Glu Gln Ser Thr
                1365                1370                1375    
Arg Ser Ser Gly His Ser Ser Ser Glu Leu Ser Pro Asp Ala Val Glu
            1380                1385                1390        
Lys Ala Gly Met Ser Ser Asn Gln Ser Ile Ser Ser Pro Val Leu Asp
        1395                1400                1405            
Ala Val Pro Arg Thr Pro Ser Arg Glu Arg Ser Ser Ser Ala Ser Ser
    1410                1415                1420                
Pro Glu Met Lys Asp Gly Leu Pro Arg Thr Pro Ser Arg Arg Ser Arg
1425                1430                1435                1440
Ser Gly Ser Ser Pro Gly Leu Arg Asp Gly Ser Gly Thr Pro Ser Arg
                1445                1450                1455    
His Ser Leu Ser Gly Ser Ser Pro Gly Met Lys Asp Ile Pro Arg Thr
            1460                1465                1470        
Pro Ser Arg Gly Arg Ser Glu Cys Asp Ser Ser Pro Glu Pro Lys Ala
        1475                1480                1485            
Leu Pro Gln Thr Pro Arg Pro Arg Ser Arg Ser Pro Ser Ser Pro Glu
    1490                1495                1500                
Leu Asn Asn Lys Cys Leu Thr Pro Gln Arg Glu Arg Ser Gly Ser Glu
1505                1510                1515                1520
Ser Ser Val Asp Gln Lys Thr Val Ala Arg Thr Pro Leu Gly Gln Arg
                1525                1530                1535    
Ser Arg Ser Gly Ser Ser Gln Glu Leu Asp Val Lys Pro Ser Ala Ser
            1540                1545                1550        
Pro Gln Glu Arg Ser Glu Ser Asp Ser Ser Pro Asp Ser Lys Ala Lys
        1555                1560                1565            
Thr Arg Thr Pro Leu Arg Gln Arg Ser Arg Ser Gly Ser Ser Pro Glu
    1570                1575                1580                
Val Asp Ser Lys Ser Arg Leu Ser Pro Arg Arg Ser Arg Ser Gly Ser
1585                1590                1595                1600
Ser Pro Glu Val Lys Asp Lys Pro Arg Ala Ala Pro Arg Ala Gln Ser
                1605                1610                1615    
Gly Ser Asp Ser Ser Pro Glu Pro Lys Ala Pro Ala Pro Arg Ala Leu
            1620                1625                1630        
Pro Arg Arg Ser Arg Ser Gly Ser Ser Ser Lys Gly Arg Gly Pro Ser
        1635                1640                1645            
Pro Glu Gly Ser Ser Ser Thr Glu Ser Ser Pro Glu His Pro Pro Lys
    1650                1655                1660                
Ser Arg Thr Ala Arg Arg Gly Ser Arg Ser Ser Pro Glu Pro Lys Thr
1665                1670                1675                1680
Lys Ser Arg Thr Pro Pro Arg Arg Arg Ser Ser Arg Ser Ser Pro Glu
                1685                1690                1695    
Leu Thr Arg Lys Ala Arg Leu Ser Arg Arg Ser Arg Ser Ala Ser Ser
            1700                1705                1710        
Ser Pro Glu Thr Arg Ser Arg Thr Pro Pro Arg His Arg Arg Ser Pro
        1715                1720                1725            
Ser Val Ser Ser Pro Glu Pro Ala Glu Lys Ser Arg Ser Ser Arg Arg
    1730                1735                1740                
Arg Arg Ser Ala Ser Ser Pro Arg Thr Lys Thr Thr Ser Arg Arg Gly
1745                1750                1755                1760
Arg Ser Pro Ser Pro Lys Pro Arg Gly Leu Gln Arg Ser Arg Ser Arg
                1765                1770                1775    
Ser Arg Arg Glu Lys Thr Arg Thr Thr Arg Arg Arg Asp Arg Ser Gly
            1780                1785                1790        
Ser Ser Gln Ser Thr Ser Arg Arg Arg Gln Arg Ser Arg Ser Arg Ser
        1795                1800                1805            
Arg Val Thr Arg Arg Arg Arg Gly Gly Ser Gly Tyr His Ser Arg Ser
    1810                1815                1820                
Pro Ala Arg Gln Glu Ser Ser Arg Thr Ser Ser Arg Arg Arg Arg Gly
1825                1830                1835                1840
Arg Ser Arg Thr Pro Pro Thr Ser Arg Lys Arg Ser Arg Ser Arg Thr
                1845                1850                1855    
Ser Pro Ala Pro Trp Lys Arg Ser Arg Ser Arg Ala Ser Pro Ala Thr
            1860                1865                1870        
His Arg Arg Ser Arg Ser Arg Thr Pro Leu Ile Ser Arg Arg Arg Ser
        1875                1880                1885            
Arg Ser Arg Thr Ser Pro Val Ser Arg Arg Arg Ser Arg Ser Arg Thr
    1890                1895                1900                
Ser Val Thr Arg Arg Arg Ser Arg Ser Arg Ala Ser Pro Val Ser Arg
1905                1910                1915                1920
Arg Arg Ser Arg Ser Arg Thr Pro Pro Val Thr Arg Arg Arg Ser Arg
                1925                1930                1935    
Ser Arg Thr Pro Thr Thr Arg Arg Arg Ser Arg Ser Arg Thr Pro Pro
            1940                1945                1950        
Val Thr Arg Arg Arg Ser Arg Ser Arg Thr Pro Pro Val Thr Arg Arg
        1955                1960                1965            
Arg Ser Arg Ser Arg Thr Ser Pro Ile Thr Arg Arg Arg Ser Arg Ser
    1970                1975                1980                
Arg Thr Ser Pro Val Thr Arg Arg Arg Ser Arg Ser Arg Thr Ser Pro
1985                1990                1995                2000
Val Thr Arg Arg Arg Ser Arg Ser Arg Thr Ser Pro Val Thr Arg Arg
                2005                2010                2015    
Arg Ser Arg Ser Arg Thr Pro Pro Ala Gln Asp Gln Pro Arg Ser Pro
            2020                2025                2030        
Val Pro Ser Ala Phe Ser Asp Gln Ser Arg Cys Leu Ile Ala Gln Thr
        2035                2040                2045            
Thr Pro Val Ala Gly Ser Gln Ser Leu Ser Ser Gly Ala Val Ala Thr
    2050                2055                2060                
Thr Thr Ser Ser Ala Gly Asp His Asn Gly Met Leu Ser Val Pro Ala
2065                2070                2075                2080
Pro Gly Val Pro His Ser Asp Val Gly Glu Pro Pro Ala Ser Thr Gly
                2085                2090                2095    
Ala Gln Gln Pro Ser Ala Leu Ala Ala Leu Gln Pro Ala Lys Glu Arg
            2100                2105                2110        
Arg Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser
        2115                2120                2125            
Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Asp
    2130                2135                2140                
Ser Glu Gly Ser Ser Leu Pro Val Gln Pro Glu Val Ala Leu Lys Arg
2145                2150                2155                2160
Ser Pro Ala Pro Pro Gln Pro Gln Arg Arg Leu Phe Glu Arg Asp Val
                2165                2170                2175    
Leu Arg Ser Gln Pro Gln Pro Asn Gly Arg Gly Ala Leu Ala Val Pro
            2180                2185                2190        
Val Pro Ala Pro Pro Leu His Leu Pro Pro Pro Pro Pro Pro Pro Leu
        2195                2200                2205            
Leu Pro Pro Pro Leu Pro Leu Leu Leu Leu Pro Pro His Leu Pro Pro
    2210                2215                2220                
Pro Arg Arg Leu Pro Pro Leu Pro Leu Leu Ser Leu Ala Leu Arg Pro
2225                2230                2235                2240
Cys Pro Asn Leu Gln Ala Pro Arg Ser His Pro Leu Ala Ser Gly Gly
                2245                2250                2255    
Pro Ala Ala Pro Gly Ser Gln
            2260            


<210> 2232
<211> 387
<212> PRT
<213> Homo sapiens

<400> 2232
Met Ser Phe Arg Asp Leu Arg Asn Phe Thr Glu Met Met Arg Ala Leu
 1               5                  10                  15      
Gly Tyr Pro Arg His Ile Ser Met Glu Asn Phe Arg Thr Pro Asn Phe
            20                  25                  30          
Gly Leu Val Ser Glu Val Leu Leu Trp Leu Val Lys Arg Tyr Glu Pro
        35                  40                  45              
Gln Thr Asp Ile Pro Pro Asp Val Asp Thr Glu Gln Asp Arg Val Phe
    50                  55                  60                  
Phe Ile Lys Ala Ile Ala Gln Phe Met Ala Thr Lys Ala His Ile Lys
65                  70                  75                  80  
Leu Asn Thr Lys Lys Leu Tyr Gln Ala Asp Gly Tyr Ala Val Lys Glu
                85                  90                  95      
Leu Leu Lys Ile Thr Ser Val Leu Tyr Asn Ala Met Lys Thr Lys Gly
            100                 105                 110         
Met Glu Gly Ser Glu Ile Val Glu Glu Asp Val Asn Lys Phe Lys Phe
        115                 120                 125             
Asp Leu Gly Ser Lys Ile Ala Asp Leu Lys Ala Ala Arg Gln Leu Ala
    130                 135                 140                 
Ser Glu Ile Thr Ser Lys Gly Ala Ser Leu Tyr Asp Leu Leu Gly Met
145                 150                 155                 160 
Glu Val Glu Leu Arg Glu Met Arg Thr Glu Ala Ile Ala Arg Pro Leu
                165                 170                 175     
Glu Ile Asn Glu Thr Glu Lys Val Met Arg Ile Ala Ile Lys Glu Ile
            180                 185                 190         
Leu Thr Gln Val Gln Lys Thr Lys Asp Leu Leu Asn Asn Val Ala Ser
        195                 200                 205             
Asp Glu Ala Asn Leu Glu Ala Lys Ile Glu Lys Arg Lys Leu Glu Leu
    210                 215                 220                 
Glu Arg Asn Arg Lys Arg Leu Glu Thr Leu Gln Ser Val Arg Pro Cys
225                 230                 235                 240 
Phe Met Asp Glu Tyr Glu Lys Thr Glu Glu Glu Leu Gln Lys Gln Tyr
                245                 250                 255     
Asp Thr Tyr Leu Glu Lys Phe Gln Asn Leu Thr Tyr Leu Glu Gln Gln
            260                 265                 270         
Leu Glu Asp His His Arg Met Glu Gln Glu Arg Phe Glu Glu Ala Lys
        275                 280                 285             
Asn Thr Leu Cys Leu Ile Gln Asn Lys Leu Lys Glu Glu Glu Lys Arg
    290                 295                 300                 
Leu Leu Lys Ser Gly Ser Asn Asp Asp Ser Asp Ile Asp Ile Gln Glu
305                 310                 315                 320 
Asp Asp Glu Ser Asp Ser Glu Leu Glu Glu Arg Arg Leu Pro Lys Pro
                325                 330                 335     
Gln Thr Ala Met Glu Met Leu Met Gln Gly Arg Pro Gly Lys Arg Ile
            340                 345                 350         
Val Gly Thr Met Gln Gly Gly Asp Ser Asp Asp Asn Val Ser Pro Pro
        355                 360                 365             
Leu Pro Ser Val Val Leu Cys Thr Leu Gly Leu Ala Val Pro Ile Asp
    370                 375                 380                 
Gly Ser Gly
385         


<210> 2233
<211> 599
<212> PRT
<213> Homo sapiens

<400> 2233
Met Thr Asp Ser Lys Tyr Phe Thr Thr Thr Lys Lys Gly Glu Ile Phe
 1               5                  10                  15      
Glu Leu Lys Ala Glu Leu Asn Ser Asp Lys Lys Glu Lys Lys Lys Glu
            20                  25                  30          
Ala Val Lys Lys Val Ile Ala Ser Met Thr Val Gly Lys Asp Val Ser
        35                  40                  45              
Ala Leu Phe Pro Asp Val Val Asn Cys Met Gln Thr Asp Asn Leu Glu
    50                  55                  60                  
Leu Lys Lys Leu Val Tyr Leu Tyr Leu Met Asn Tyr Ala Lys Ser Gln
65                  70                  75                  80  
Pro Asp Met Ala Ile Met Ala Val Asn Thr Phe Val Lys Asp Cys Glu
                85                  90                  95      
Asp Pro Asn Pro Leu Ile Arg Ala Leu Ala Val Arg Thr Met Gly Cys
            100                 105                 110         
Ile Arg Val Asp Lys Ile Thr Glu Tyr Leu Cys Glu Pro Leu Arg Lys
        115                 120                 125             
Cys Leu Lys Asp Glu Asp Pro Tyr Val Arg Lys Thr Ala Ala Val Cys
    130                 135                 140                 
Val Ala Lys Leu His Asp Ile Asn Ala Gln Leu Val Glu Asp Gln Gly
145                 150                 155                 160 
Phe Leu Asp Thr Leu Lys Asp Leu Ile Ser Asp Ser Asn Pro Met Val
                165                 170                 175     
Val Ala Asn Ala Val Ala Ala Leu Ser Glu Ile Ala Glu Ser His Pro
            180                 185                 190         
Ser Ser Asn Leu Leu Asp Leu Asn Pro Gln Ser Ile Asn Lys Leu Leu
        195                 200                 205             
Thr Ala Leu Asn Glu Cys Thr Glu Trp Gly Gln Ile Phe Ile Leu Asp
    210                 215                 220                 
Cys Leu Ala Asn Tyr Met Pro Lys Asp Asp Arg Glu Ala Gln Ser Ile
225                 230                 235                 240 
Cys Glu Arg Val Thr Pro Arg Leu Ser His Ala Asn Ser Ala Val Val
                245                 250                 255     
Leu Ser Ala Val Lys Val Leu Met Lys Phe Met Glu Met Leu Ser Lys
            260                 265                 270         
Asp Leu Asp Tyr Tyr Gly Thr Leu Leu Lys Lys Leu Ala Pro Pro Leu
        275                 280                 285             
Val Thr Leu Leu Ser Ala Glu Pro Glu Leu Gln Tyr Val Ala Leu Arg
    290                 295                 300                 
Asn Ile Asn Leu Ile Val Gln Lys Arg Pro Glu Ile Leu Lys His Glu
305                 310                 315                 320 
Met Lys Val Phe Phe Val Lys Tyr Asn Asp Pro Ile Tyr Val Lys Leu
                325                 330                 335     
Glu Lys Leu Asp Ile Met Ile Arg Leu Ala Ser Gln Ala Asn Ile Ala
            340                 345                 350         
Gln Val Leu Ala Glu Leu Lys Glu Tyr Ala Thr Glu Val Asp Val Asp
        355                 360                 365             
Phe Val Arg Lys Ala Val Arg Ala Ile Gly Arg Cys Ala Ile Lys Val
    370                 375                 380                 
Glu Gln Ser Ala Glu Arg Cys Val Ser Thr Leu Leu Asp Leu Ile Gln
385                 390                 395                 400 
Thr Lys Val Asn Tyr Val Val Gln Glu Ala Ile Val Val Ile Lys Asp
                405                 410                 415     
Ile Phe Arg Lys Tyr Pro Asn Lys Tyr Glu Ser Val Ile Ala Thr Leu
            420                 425                 430         
Cys Glu Asn Leu Asp Ser Leu Asp Glu Pro Glu Ala Arg Ala Ala Met
        435                 440                 445             
Ile Trp Ile Val Gly Glu Tyr Ala Glu Arg Ile Asp Asn Ala Asp Glu
    450                 455                 460                 
Leu Leu Glu Ser Phe Leu Glu Gly Phe His Asp Glu Ser Thr Gln Val
465                 470                 475                 480 
Gln Leu Gln Leu Leu Thr Ala Ile Val Lys Leu Phe Leu Lys Lys Pro
                485                 490                 495     
Thr Glu Thr Gln Glu Leu Val Gln Gln Val Leu Ser Leu Ala Thr Gln
            500                 505                 510         
Asp Ser Asp Asn Pro Asp Leu Arg Asp Arg Gly Tyr Ile Tyr Trp Arg
        515                 520                 525             
Leu Leu Ser Thr Asp Pro Val Ala Ala Lys Glu Val Val Leu Ala Glu
    530                 535                 540                 
Lys Pro Leu Ile Ser Glu Glu Thr Asp Leu Ile Glu Pro Thr Leu Leu
545                 550                 555                 560 
Asp Glu Leu Ile Cys Tyr Ile Gly Thr Leu Ala Ser Val Tyr His Lys
                565                 570                 575     
Pro Pro Ser Ala Phe Val Glu Gly Gly Arg Gly Val Val His Lys Ser
            580                 585                 590         
Leu Pro Pro Arg Thr Ala Ser
        595                 


<210> 2234
<211> 166
<212> PRT
<213> Homo sapiens

<400> 2234
Met Ser Glu Pro Gln Pro Arg Gly Ala Glu Arg Asp Leu Tyr Arg Asp
 1               5                  10                  15      
Thr Trp Val Arg Tyr Leu Gly Tyr Ala Asn Glu Val Gly Glu Ala Phe
            20                  25                  30          
Arg Ser Leu Val Pro Ala Ala Val Val Trp Leu Ser Tyr Gly Val Ala
        35                  40                  45              
Ser Ser Tyr Val Leu Ala Asp Ala Ile Asp Lys Gly Lys Lys Ala Gly
    50                  55                  60                  
Glu Val Pro Ser Pro Glu Ala Gly Arg Ser Ala Arg Val Thr Val Ala
65                  70                  75                  80  
Val Val Asp Thr Phe Val Trp Gln Ala Leu Ala Ser Val Ala Ile Pro
                85                  90                  95      
Gly Phe Thr Ile Asn Arg Val Cys Ala Ala Ser Leu Tyr Val Leu Gly
            100                 105                 110         
Thr Ala Thr Arg Trp Pro Leu Ala Val Arg Lys Trp Thr Thr Thr Ala
        115                 120                 125             
Leu Gly Leu Leu Thr Ile Pro Ile Ile Ile His Pro Ile Asp Arg Ser
    130                 135                 140                 
Val Asp Phe Leu Leu Asp Ser Ser Leu Arg Lys Leu Tyr Pro Thr Val
145                 150                 155                 160 
Gly Lys Pro Ser Ser Ser
                165     


<210> 2235
<211> 985
<212> PRT
<213> Homo sapiens

<400> 2235
Met Asp Arg Arg Ser Met Gly Glu Thr Glu Ser Gly Asp Ala Phe Leu
 1               5                  10                  15      
Asp Leu Lys Lys Pro Pro Ala Ser Lys Cys Pro His Arg Tyr Thr Lys
            20                  25                  30          
Glu Glu Leu Leu Asp Ile Lys Glu Leu Pro His Ser Lys Gln Arg Pro
        35                  40                  45              
Ser Cys Leu Ser Glu Lys Tyr Asp Ser Asp Gly Val Trp Asp Pro Glu
    50                  55                  60                  
Lys Trp His Ala Ser Leu Tyr Pro Ala Ser Gly Arg Ser Ser Pro Val
65                  70                  75                  80  
Glu Ser Leu Lys Lys Glu Leu Asp Thr Asp Arg Pro Ser Leu Val Arg
                85                  90                  95      
Arg Ile Val Asp Pro Arg Glu Arg Val Lys Glu Asp Asp Leu Asp Val
            100                 105                 110         
Val Leu Ser Pro Gln Arg Arg Ser Phe Gly Gly Gly Cys His Val Thr
        115                 120                 125             
Ala Ala Val Ser Ser Arg Arg Ser Gly Ser Pro Leu Glu Lys Asp Ser
    130                 135                 140                 
Asp Gly Leu Arg Leu Leu Gly Gly Arg Arg Ile Gly Ser Gly Arg Ile
145                 150                 155                 160 
Ile Ser Ala Arg Thr Phe Glu Lys Asp His Arg Leu Ser Asp Lys Asp
                165                 170                 175     
Leu Arg Asp Leu Arg Asp Arg Asp Arg Glu Arg Asp Phe Lys Asp Lys
            180                 185                 190         
Arg Phe Arg Arg Glu Phe Gly Asp Ser Lys Arg Val Phe Gly Glu Arg
        195                 200                 205             
Arg Arg Asn Asp Ser Tyr Thr Glu Glu Glu Pro Glu Trp Phe Ser Ala
    210                 215                 220                 
Gly Pro Thr Ser Gln Ser Glu Thr Ile Glu Leu Thr Gly Phe Asp Asp
225                 230                 235                 240 
Lys Ile Leu Glu Glu Asp His Lys Gly Arg Lys Arg Thr Arg Arg Arg
                245                 250                 255     
Thr Ala Ser Val Lys Glu Gly Ile Val Glu Cys Asn Gly Gly Val Ala
            260                 265                 270         
Glu Glu Asp Glu Val Glu Val Ile Leu Ala Gln Glu Pro Ala Ala Asp
        275                 280                 285             
Gln Glu Val Pro Arg Asp Ala Val Leu Pro Glu Gln Ser Pro Gly Asp
    290                 295                 300                 
Phe Asp Phe Asn Glu Phe Phe Asn Leu Asp Lys Val Pro Cys Leu Ala
305                 310                 315                 320 
Ser Met Ile Glu Asp Val Leu Gly Glu Gly Ser Val Ser Ala Ser Arg
                325                 330                 335     
Phe Ser Arg Trp Phe Ser Asn Pro Ser Arg Ser Gly Ser Arg Ser Ser
            340                 345                 350         
Ser Leu Gly Ser Thr Pro His Glu Glu Leu Glu Arg Leu Ala Gly Leu
        355                 360                 365             
Glu Gln Ala Ile Leu Ser Pro Gly Gln Asn Ser Gly Asn Tyr Phe Ala
    370                 375                 380                 
Pro Ile Pro Leu Glu Asp His Ala Glu Asn Lys Val Asp Ile Leu Glu
385                 390                 395                 400 
Met Leu Gln Lys Ala Lys Val Asp Leu Lys Pro Leu Leu Ser Ser Leu
                405                 410                 415     
Ser Ala Asn Lys Glu Lys Leu Lys Glu Ser Ser His Ser Gly Val Val
            420                 425                 430         
Leu Ser Val Glu Glu Val Glu Ala Gly Leu Lys Gly Leu Lys Val Asp
        435                 440                 445             
Gln Gln Val Lys Asn Ser Thr Pro Phe Met Ala Glu His Leu Glu Glu
    450                 455                 460                 
Thr Leu Ser Ala Val Thr Asn Asn Arg Gln Leu Lys Lys Asp Gly Asp
465                 470                 475                 480 
Met Thr Ala Phe Asn Lys Leu Val Ser Thr Met Lys Ala Ser Gly Thr
                485                 490                 495     
Leu Pro Ser Gln Pro Lys Val Ser Arg Asn Leu Glu Ser His Leu Met
            500                 505                 510         
Ser Pro Ala Glu Ile Pro Gly Gln Pro Val Pro Lys Asn Ile Leu Gln
        515                 520                 525             
Glu Leu Leu Gly Gln Pro Val Gln Arg Pro Ala Ser Ser Asn Leu Leu
    530                 535                 540                 
Ser Gly Leu Met Gly Ser Leu Glu Pro Thr Thr Ser Leu Leu Gly Gln
545                 550                 555                 560 
Arg Ala Pro Ser Pro Pro Leu Ser Gln Val Phe Gln Thr Arg Ala Ala
                565                 570                 575     
Ser Ala Asp Tyr Leu Arg Pro Arg Ile Pro Ser Pro Ile Gly Phe Thr
            580                 585                 590         
Pro Gly Pro Gln Gln Leu Leu Gly Asp Pro Phe Gln Gly Met Arg Lys
        595                 600                 605             
Pro Met Ser Pro Ile Thr Ala Gln Met Ser Gln Leu Glu Leu Gln Gln
    610                 615                 620                 
Ala Ala Leu Glu Gly Leu Ala Leu Pro His Asp Leu Ala Val Gln Ala
625                 630                 635                 640 
Ala Asn Phe Tyr Gln Pro Gly Phe Gly Lys Pro Gln Val Asp Arg Thr
                645                 650                 655     
Arg Asp Gly Phe Arg Asn Arg Gln Gln Arg Val Thr Lys Ser Pro Ala
            660                 665                 670         
Pro Val His Arg Gly Asn Ser Ser Ser Pro Ala Pro Ala Ala Ser Ile
        675                 680                 685             
Thr Ser Met Leu Ser Pro Ser Phe Thr Pro Thr Ser Val Ile Arg Lys
    690                 695                 700                 
Met Tyr Glu Ser Lys Glu Lys Ser Lys Glu Glu Pro Ala Ser Gly Lys
705                 710                 715                 720 
Ala Ala Leu Gly Asp Ser Lys Glu Asp Thr Gln Lys Ala Ser Glu Glu
                725                 730                 735     
Asn Leu Leu Ser Ser Ser Ser Val Pro Ser Ala Asp Arg Asp Ser Ser
            740                 745                 750         
Pro Thr Thr Asn Ser Lys Leu Ser Ala Leu Gln Arg Ser Ser Cys Ser
        755                 760                 765             
Thr Pro Leu Ser Gln Ala Asn Arg Tyr Thr Lys Glu Gln Asp Tyr Arg
    770                 775                 780                 
Pro Lys Ala Thr Gly Arg Lys Thr Pro Thr Leu Ala Ser Pro Val Pro
785                 790                 795                 800 
Thr Thr Pro Phe Leu Arg Pro Val His Gln Val Pro Leu Val Pro His
                805                 810                 815     
Val Pro Met Val Arg Pro Ala His Gln Leu His Pro Gly Leu Val Gln
            820                 825                 830         
Arg Met Leu Ala Gln Gly Val His Pro Gln His Leu Pro Ser Leu Leu
        835                 840                 845             
Gln Thr Gly Val Leu Pro Pro Gly Met Asp Leu Ser His Leu Gln Gly
    850                 855                 860                 
Ile Ser Gly Pro Ile Leu Gly Gln Pro Phe Tyr Pro Leu Pro Ala Ala
865                 870                 875                 880 
Ser His Pro Leu Leu Asn Pro Arg Pro Gly Thr Pro Leu His Leu Ala
                885                 890                 895     
Met Val Gln Gln Gln Leu Gln Arg Ser Val Leu His Pro Pro Gly Ser
            900                 905                 910         
Gly Ser His Ala Ala Ala Val Ser Val Gln Thr Thr Pro Gln Asn Val
        915                 920                 925             
Pro Ser Arg Ser Gly Leu Pro His Met His Ser Gln Leu Glu His Arg
    930                 935                 940                 
Pro Ser Gln Arg Ser Ser Ser Pro Val Gly Leu Ala Lys Trp Phe Gly
945                 950                 955                 960 
Ser Asp Val Leu Gln Gln Pro Leu Pro Ser Met Pro Ala Lys Val Ile
                965                 970                 975     
Ser Val Asp Glu Leu Glu Tyr Arg Gln
            980                 985 


<210> 2236
<211> 288
<212> PRT
<213> Homo sapiens

<400> 2236
Met Ala Ala Leu Phe Gln Glu Ala Ser Ser Cys Pro Val Cys Ser Asp
 1               5                  10                  15      
Tyr Leu Glu Lys Pro Met Ser Leu Glu Cys Gly Cys Ala Val Cys Leu
            20                  25                  30          
Lys Cys Ile Asn Ser Leu Gln Lys Glu Pro His Gly Glu Asp Leu Leu
        35                  40                  45              
Cys Cys Cys Ser Ser Met Val Ser Arg Lys Asn Lys Ile Arg Arg Asn
    50                  55                  60                  
Arg Gln Leu Glu Arg Leu Ala Ser His Ile Lys Glu Leu Glu Pro Lys
65                  70                  75                  80  
Leu Lys Lys Ile Leu Gln Met Asn Pro Arg Met Arg Lys Phe Gln Val
                85                  90                  95      
Asp Met Thr Leu Asp Ala Asn Thr Ala Asn Asn Phe Leu Leu Ile Ser
            100                 105                 110         
Asp Asp Leu Arg Ser Val Arg Ser Gly Arg Ile Arg Gln Asn Arg Gln
        115                 120                 125             
Asp Leu Ala Glu Arg Phe Asp Val Ser Val Cys Ile Leu Gly Ser Pro
    130                 135                 140                 
Arg Phe Thr Cys Gly Arg His Cys Trp Glu Val Asp Val Gly Thr Ser
145                 150                 155                 160 
Thr Glu Trp Asp Leu Gly Val Cys Arg Glu Ser Val His Arg Lys Gly
                165                 170                 175     
Arg Ile Gln Leu Thr Thr Glu Leu Gly Phe Trp Thr Val Ser Leu Arg
            180                 185                 190         
Asp Gly Gly Arg Leu Ser Ala Thr Thr Val Pro Leu Thr Phe Leu Phe
        195                 200                 205             
Val Asp Arg Lys Leu Gln Arg Val Gly Ile Phe Leu Asp Met Gly Met
    210                 215                 220                 
Gln Asn Val Ser Phe Phe Asp Ala Glu Ser Gly Ser His Val Tyr Thr
225                 230                 235                 240 
Phe Arg Ser Val Ser Ala Glu Glu Pro Leu Arg Pro Phe Leu Ala Pro
                245                 250                 255     
Ser Val Pro Pro Asn Gly Asp Gln Gly Val Leu Ser Ile Cys Pro Leu
            260                 265                 270         
Met Asn Ser Gly Thr Thr Asp Ala Pro Val Arg Pro Gly Glu Ala Lys
        275                 280                 285             


<210> 2237
<211> 297
<212> PRT
<213> Homo sapiens

<400> 2237
Met Val His Gln Val Leu Tyr Arg Ala Leu Val Ser Thr Lys Trp Leu
 1               5                  10                  15      
Ala Glu Ser Ile Arg Thr Gly Lys Leu Gly Pro Gly Leu Arg Val Leu
            20                  25                  30          
Asp Ala Ser Trp Tyr Ser Pro Gly Thr Arg Glu Ala Arg Lys Glu Tyr
        35                  40                  45              
Leu Glu Arg His Val Pro Gly Ala Ser Phe Phe Asp Ile Glu Glu Cys
    50                  55                  60                  
Arg Asp Thr Ala Ser Pro Tyr Glu Met Met Leu Pro Ser Glu Ala Gly
65                  70                  75                  80  
Phe Ala Glu Tyr Val Gly Arg Leu Gly Ile Ser Asn His Thr His Val
                85                  90                  95      
Val Val Tyr Asp Gly Glu His Leu Gly Ser Phe Tyr Ala Pro Arg Val
            100                 105                 110         
Trp Trp Met Phe Arg Val Phe Gly His Arg Thr Val Ser Val Leu Asn
        115                 120                 125             
Gly Gly Phe Arg Asn Trp Leu Lys Glu Gly His Pro Val Thr Ser Glu
    130                 135                 140                 
Pro Ser Arg Pro Glu Pro Ala Val Phe Lys Ala Thr Leu Asp Arg Ser
145                 150                 155                 160 
Leu Leu Lys Thr Tyr Glu Gln Val Leu Glu Asn Leu Glu Ser Lys Arg
                165                 170                 175     
Phe Gln Leu Val Asp Ser Arg Ser Gln Gly Arg Phe Leu Gly Thr Glu
            180                 185                 190         
Pro Glu Pro Asp Ala Val Gly Leu Asp Ser Gly His Ile Arg Gly Ala
        195                 200                 205             
Val Asn Met Pro Phe Met Asp Phe Leu Thr Glu Asp Gly Phe Glu Lys
    210                 215                 220                 
Gly Pro Glu Glu Leu Arg Ala Leu Phe Gln Thr Lys Lys Val Asp Leu
225                 230                 235                 240 
Ser Gln Pro Leu Ile Ala Thr Cys Arg Lys Gly Val Thr Ala Cys His
                245                 250                 255     
Val Ala Leu Ala Ala Tyr Leu Cys Gly Lys Pro Asp Val Ala Val Tyr
            260                 265                 270         
Asp Gly Ser Trp Ser Glu Trp Phe Arg Arg Ala Pro Pro Glu Ser Arg
        275                 280                 285             
Val Ser Gln Gly Lys Ser Glu Lys Ala
    290                 295         


<210> 2238
<211> 117
<212> PRT
<213> Homo sapiens

<400> 2238
Met Thr Pro Gly Ala Ser Ala Leu Pro Cys Arg His Pro Ser Thr Ser
 1               5                  10                  15      
Trp Ala Ser Leu Ser Ala Ser Thr Ser Thr Ser Arg Leu Glu Leu Met
            20                  25                  30          
Glu Thr Trp Ser Ser Gly Pro Ile His Pro Ser Pro Ala Met Met Thr
        35                  40                  45              
Arg Ala Ser Trp Thr Trp Ser Ser Arg Phe Thr Ser Arg Thr Pro Ile
    50                  55                  60                  
Pro Ser Phe Pro Leu Glu Gly Arg Cys Leu Ser Thr Trp Arg Ala Cys
65                  70                  75                  80  
Arg Leu Glu Thr Pro Leu Ser Ser Gly Ala Pro Val Gly Cys Trp Ser
                85                  90                  95      
Thr Arg Ala Lys Gly Ser Ser Pro Ser Asp Leu Thr Lys Ser Pro Thr
            100                 105                 110         
Leu Ser Ser Gly Gln
        115         


<210> 2239
<211> 1480
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 499, 500, 501, 502, 503, 504, 505, 506, 507, 508, 509
<223> Xaa = Any Amino Acid

<400> 2239
Met Glu Leu Ser Glu Leu Ala Arg Glu Gly Glu Leu Ser Met Glu Glu
 1               5                  10                  15      
Leu Leu Gln Gln Tyr Ala Gly Ala Tyr Ala Pro Gly Ser Gly Ser Ser
            20                  25                  30          
Glu Asp Glu Asp Glu Asp Glu Val Asp Ala Asn Ser Ser Asp Cys Glu
        35                  40                  45              
Pro Glu Gly Pro Val Glu Ala Glu Glu Pro Pro Gln Glu Asp Ser Ser
    50                  55                  60                  
Ser Gln Ser Asp Ser Val Glu Asp Arg Ser Glu Asp Glu Glu Asp Glu
65                  70                  75                  80  
His Ser Glu Glu Glu Glu Thr Ser Gly Ser Ser Ala Ser Glu Glu Ser
                85                  90                  95      
Glu Ser Glu Glu Ser Glu Asp Ala Gln Ser Gln Ser Gln Ala Asp Glu
            100                 105                 110         
Glu Glu Glu Asp Asp Asp Phe Gly Val Glu Tyr Leu Leu Ala Arg Asp
        115                 120                 125             
Glu Glu Gln Ser Glu Ala Asp Ala Gly Ser Gly Pro Pro Thr Pro Gly
    130                 135                 140                 
Pro Thr Thr Leu Gly Pro Lys Lys Glu Ile Thr Asp Ile Ala Ala Ala
145                 150                 155                 160 
Ala Glu Ser Leu Gln Pro Lys Gly Tyr Thr Leu Ala Thr Thr Gln Val
                165                 170                 175     
Lys Thr Pro Ile Pro Leu Leu Leu Arg Gly Gln Leu Arg Glu Tyr Gln
            180                 185                 190         
His Ile Gly Leu Asp Trp Leu Val Thr Met Tyr Glu Lys Lys Leu Asn
        195                 200                 205             
Gly Ile Leu Ala Asp Glu Met Gly Leu Gly Lys Thr Ile Gln Thr Ile
    210                 215                 220                 
Ser Leu Leu Ala His Leu Ala Cys Glu Lys Gly Asn Trp Gly Pro His
225                 230                 235                 240 
Leu Ile Ile Val Pro Thr Ser Val Met Leu Asn Trp Glu Met Glu Leu
                245                 250                 255     
Lys Arg Trp Cys Pro Ser Phe Lys Ile Leu Thr Tyr Tyr Gly Ala Gln
            260                 265                 270         
Lys Glu Arg Lys Leu Lys Arg Gln Gly Trp Thr Lys Pro Asn Ala Phe
        275                 280                 285             
His Val Cys Ile Thr Ser Tyr Lys Leu Val Leu Gln Asp His Gln Ala
    290                 295                 300                 
Phe Arg Arg Lys Asn Trp Arg Tyr Leu Ile Leu Asp Glu Ala Gln Asn
305                 310                 315                 320 
Ile Lys Asn Phe Lys Ser Gln Arg Trp Gln Ser Leu Leu Asn Phe Asn
                325                 330                 335     
Ser Gln Arg Arg Leu Leu Leu Thr Gly Thr Pro Leu Gln Asn Ser Leu
            340                 345                 350         
Met Glu Leu Trp Ser Leu Met His Phe Leu Met Pro His Val Phe Gln
        355                 360                 365             
Ser His Arg Glu Phe Lys Glu Trp Phe Ser Asn Pro Leu Thr Gly Met
    370                 375                 380                 
Ile Glu Gly Ser Gln Glu Tyr Asn Glu Gly Leu Val Lys Arg Leu His
385                 390                 395                 400 
Lys Val Leu Arg Pro Phe Leu Leu Arg Arg Val Lys Val Asp Val Glu
                405                 410                 415     
Lys Gln Met Pro Lys Lys Tyr Glu His Val Ile Arg Cys Arg Leu Ser
            420                 425                 430         
Lys Arg Gln Arg Cys Leu Tyr Asp Asp Phe Met Ala Gln Thr Thr Thr
        435                 440                 445             
Lys Glu Thr Leu Ala Thr Gly His Phe Met Ser Val Ile Asn Ile Leu
    450                 455                 460                 
Met Gln Leu Arg Lys Val Cys Asn His Pro Asn Leu Phe Asp Pro Arg
465                 470                 475                 480 
Pro Val Thr Ser Pro Phe Ile Thr Pro Gly Ile Cys Phe Ser Thr Ala
                485                 490                 495     
Ser Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Ile Asp
            500                 505                 510         
Met Gly Arg Phe Asp Leu Ile Gly Leu Glu Gly Arg Val Ser Arg Tyr
        515                 520                 525             
Glu Ala Asp Thr Phe Leu Pro Arg His Arg Leu Ser Arg Arg Val Leu
    530                 535                 540                 
Leu Glu Val Ala Thr Ala Pro Asp Pro Pro Pro Arg Pro Lys Pro Val
545                 550                 555                 560 
Lys Met Lys Val Asn Arg Met Leu Gln Pro Val Pro Lys Gln Glu Gly
                565                 570                 575     
Arg Thr Val Val Val Val Asn Asn Pro Arg Ala Pro Leu Gly Pro Val
            580                 585                 590         
Pro Val Arg Pro Pro Pro Gly Pro Glu Leu Ser Ala Gln Pro Thr Pro
        595                 600                 605             
Gly Pro Val Pro Gln Val Leu Pro Ala Ser Leu Met Val Ser Ala Ser
    610                 615                 620                 
Pro Ala Gly Pro Pro Leu Ile Pro Ala Ser Arg Pro Pro Gly Pro Val
625                 630                 635                 640 
Leu Leu Pro Pro Leu Gln Pro Asn Ser Gly Ser Leu Pro Gln Val Leu
                645                 650                 655     
Pro Ser Pro Leu Gly Val Leu Ser Gly Thr Ser Arg Pro Pro Thr Pro
            660                 665                 670         
Thr Leu Ser Leu Lys Pro Thr Pro Pro Ala Pro Val Arg Leu Ser Pro
        675                 680                 685             
Ala Pro Pro Pro Gly Ser Ser Ser Leu Leu Lys Pro Leu Thr Val Pro
    690                 695                 700                 
Pro Gly Tyr Thr Phe Pro Pro Ala Ala Ala Thr Thr Thr Ser Thr Thr
705                 710                 715                 720 
Thr Ala Thr Ala Thr Thr Thr Ala Val Pro Ala Pro Thr Pro Ala Pro
                725                 730                 735     
Gln Arg Leu Ile Leu Ser Pro Asp Met Gln Ala Arg Leu Pro Ser Gly
            740                 745                 750         
Glu Val Val Ser Ile Gly Gln Leu Ala Ser Leu Ala Gln Arg Pro Val
        755                 760                 765             
Ala Asn Ala Gly Gly Ser Lys Pro Leu Thr Phe Gln Ile Gln Gly Asn
    770                 775                 780                 
Lys Leu Thr Leu Thr Gly Ala Gln Val Arg Gln Leu Ala Val Gly Gln
785                 790                 795                 800 
Pro Arg Pro Leu Gln Arg Asn Val Val His Leu Val Ser Ala Gly Gly
                805                 810                 815     
Gln His His Leu Ile Ser Gln Pro Ala His Val Ala Leu Ile Gln Ala
            820                 825                 830         
Val Ala Pro Thr Pro Gly Pro Thr Pro Val Ser Val Leu Pro Ser Ser
        835                 840                 845             
Thr Pro Ser Thr Thr Pro Ala Pro Thr Gly Leu Ser Leu Pro Leu Ala
    850                 855                 860                 
Ala Asn Gln Val Pro Pro Thr Met Val Asn Asn Thr Gly Val Val Lys
865                 870                 875                 880 
Ile Val Val Arg Gln Ala Pro Arg Asp Gly Leu Thr Pro Val Pro Pro
                885                 890                 895     
Leu Ala Pro Ala Pro Arg Pro Pro Ser Ser Gly Leu Pro Ala Val Leu
            900                 905                 910         
Asn Pro Arg Pro Thr Leu Thr Pro Gly Arg Leu Pro Thr Pro Thr Leu
        915                 920                 925             
Gly Thr Ala Arg Ala Pro Met Pro Thr Pro Thr Leu Val Arg Pro Leu
    930                 935                 940                 
Leu Lys Leu Val His Ser Pro Ser Pro Glu Val Ser Ala Ser Ala Pro
945                 950                 955                 960 
Gly Ala Ala Pro Leu Thr Ile Ser Ser Pro Leu His Val Pro Ser Ser
                965                 970                 975     
Leu Pro Gly Pro Ala Ser Ser Pro Met Pro Ile Pro Asn Ser Ser Pro
            980                 985                 990         
Leu Ala Ser Pro Val Ser Ser Thr Val Ser Val Pro Leu Ser Ser Ser
        995                 1000                1005            
Leu Pro Ile Ser Val Pro Thr Thr Leu Pro Ala Pro Ala Ser Ala Pro
    1010                1015                1020                
Leu Thr Ile Pro Ile Ser Ala Pro Leu Thr Val Ser Ala Ser Gly Pro
1025                1030                1035                1040
Ala Leu Leu Thr Ser Val Thr Pro Pro Leu Ala Pro Val Val Pro Ala
                1045                1050                1055    
Ala Pro Gly Pro Pro Ser Leu Ala Pro Ser Gly Ala Ser Pro Ser Ala
            1060                1065                1070        
Ser Ala Leu Thr Leu Gly Leu Ala Thr Ala Pro Ser Leu Ser Ser Ser
        1075                1080                1085            
Gln Thr Pro Gly His Pro Leu Leu Leu Ala Pro Thr Ser Ser His Val
    1090                1095                1100                
Pro Gly Leu Asn Ser Thr Val Ala Pro Ala Cys Ser Pro Val Leu Val
1105                1110                1115                1120
Pro Ala Ser Ala Leu Ala Ser Pro Phe Pro Ser Ala Pro Asn Pro Ala
                1125                1130                1135    
Pro Ala Gln Ala Ser Leu Leu Ala Pro Ala Ser Ser Ala Ser Gln Ala
            1140                1145                1150        
Leu Ala Thr Pro Leu Ala Pro Met Ala Ala Pro Gln Thr Ala Ile Leu
        1155                1160                1165            
Ala Pro Ser Pro Ala Pro Pro Leu Ala Pro Leu Pro Val Leu Ala Pro
    1170                1175                1180                
Ser Pro Gly Ala Ala Pro Val Leu Ala Ser Ser Gln Thr Pro Val Pro
1185                1190                1195                1200
Val Met Ala Pro Ser Ser Thr Pro Gly Thr Ser Leu Ala Ser Ala Ser
                1205                1210                1215    
Pro Val Pro Ala Pro Thr Pro Val Leu Ala Pro Ser Ser Thr Gln Thr
            1220                1225                1230        
Met Leu Pro Ala Pro Val Pro Ser Pro Leu Pro Ser Pro Ala Ser Thr
        1235                1240                1245            
Gln Thr Leu Ala Leu Ala Pro Ala Leu Ala Pro Thr Leu Gly Gly Ser
    1250                1255                1260                
Ser Pro Ser Gln Thr Leu Ser Leu Gly Thr Gly Asn Pro Gln Gly Pro
1265                1270                1275                1280
Phe Pro Thr Gln Thr Leu Ser Leu Thr Pro Ala Ser Ser Leu Val Pro
                1285                1290                1295    
Thr Pro Ala Gln Thr Leu Ser Leu Ala Pro Gly Pro Pro Leu Gly Pro
            1300                1305                1310        
Thr Gln Thr Leu Ser Leu Ala Pro Ala Pro Pro Leu Ala Pro Ala Ser
        1315                1320                1325            
Pro Val Gly Pro Ala Pro Ala His Thr Leu Thr Leu Ala Pro Ala Ser
    1330                1335                1340                
Ser Ser Ala Ser Leu Leu Ala Pro Ala Ser Val Gln Thr Leu Thr Leu
1345                1350                1355                1360
Ser Pro Ala Pro Val Pro Thr Leu Gly Pro Ala Ala Ala Gln Thr Leu
                1365                1370                1375    
Ala Leu Ala Pro Ala Ser Thr Gln Ser Pro Ala Ser Gln Ala Ser Ser
            1380                1385                1390        
Leu Val Val Ser Ala Ser Gly Ala Ala Pro Leu Pro Val Thr Met Val
        1395                1400                1405            
Ser Arg Leu Pro Val Ser Lys Asp Glu Pro Asp Thr Leu Thr Leu Arg
    1410                1415                1420                
Ser Gly Pro Pro Ser Pro Pro Ser Thr Ala Thr Ser Phe Gly Gly Pro
1425                1430                1435                1440
Arg Pro Arg Arg Gln Pro Pro Pro Pro Pro Arg Ser Pro Phe Tyr Leu
                1445                1450                1455    
Val Ser Phe Thr Ser Ser Arg Gly Asn Arg Lys Leu Ser Phe Phe Gly
            1460                1465                1470        
Val Leu Val Gly Trp Met Glu Gln
        1475                1480


<210> 2240
<211> 515
<212> PRT
<213> Homo sapiens

<400> 2240
Met Ala Thr Ser Thr Gly Arg Trp Leu Leu Leu Arg Leu Ala Leu Phe
 1               5                  10                  15      
Gly Phe Leu Trp Glu Ala Ser Gly Gly Leu Asp Ser Gly Ala Ser Arg
            20                  25                  30          
Asp Asp Asp Leu Leu Leu Pro Tyr Pro Arg Ala Arg Ala Arg Leu Pro
        35                  40                  45              
Arg Asp Cys Thr Arg Val Arg Ala Gly Asn Arg Glu His Glu Ser Trp
    50                  55                  60                  
Pro Pro Pro Pro Ala Thr Pro Gly Ala Gly Gly Leu Ala Val Arg Thr
65                  70                  75                  80  
Phe Val Ser His Phe Arg Asp Arg Ala Val Ala Gly His Leu Thr Arg
                85                  90                  95      
Ala Val Glu Pro Leu Arg Thr Phe Ser Val Leu Glu Pro Gly Gly Pro
            100                 105                 110         
Gly Gly Cys Ala Ala Arg Arg Arg Ala Thr Val Glu Glu Thr Ala Arg
        115                 120                 125             
Ala Ala Asp Cys Arg Val Ala Gln Asn Gly Gly Phe Phe Arg Met Asn
    130                 135                 140                 
Ser Gly Glu Cys Leu Gly Asn Val Val Ser Asp Glu Arg Arg Val Ser
145                 150                 155                 160 
Ser Ser Gly Gly Leu Gln Asn Ala Gln Phe Gly Ile Arg Arg Asp Gly
                165                 170                 175     
Thr Leu Val Thr Gly Tyr Leu Ser Glu Glu Glu Val Leu Asp Thr Glu
            180                 185                 190         
Asn Pro Phe Val Gln Leu Leu Ser Gly Val Val Trp Leu Ile Arg Asn
        195                 200                 205             
Gly Ser Ile Tyr Ile Asn Glu Ser Gln Ala Thr Glu Cys Asp Glu Thr
    210                 215                 220                 
Gln Glu Thr Gly Ser Phe Ser Lys Phe Val Asn Val Ile Ser Ala Arg
225                 230                 235                 240 
Thr Ala Ile Gly His Asp Arg Lys Gly Gln Leu Val Leu Phe His Ala
                245                 250                 255     
Asp Gly Gln Thr Glu Gln Arg Gly Ile Asn Leu Trp Glu Met Ala Glu
            260                 265                 270         
Phe Leu Leu Lys Gln Asp Val Val Asn Ala Ile Asn Leu Asp Gly Gly
        275                 280                 285             
Gly Ser Ala Thr Phe Val Leu Asn Gly Thr Leu Ala Ser Tyr Pro Ser
    290                 295                 300                 
Asp His Cys Gln Asp Asn Met Trp Arg Cys Pro Arg Gln Val Ser Thr
305                 310                 315                 320 
Val Val Cys Val His Glu Pro Arg Cys Gln Pro Pro Asp Cys His Gly
                325                 330                 335     
His Gly Thr Cys Val Asp Gly His Cys Gln Cys Thr Gly His Phe Trp
            340                 345                 350         
Arg Gly Pro Gly Cys Asp Glu Leu Asp Cys Gly Pro Ser Asn Cys Ser
        355                 360                 365             
Gln His Gly Leu Cys Thr Glu Thr Gly Cys Arg Cys Asp Ala Gly Trp
    370                 375                 380                 
Thr Gly Ser Asn Cys Ser Glu Glu Cys Pro Leu Gly Trp His Gly Pro
385                 390                 395                 400 
Gly Cys Gln Arg Pro Cys Lys Cys Glu His His Cys Pro Cys Asp Pro
                405                 410                 415     
Lys Thr Gly Asn Cys Ser Val Ser Arg Val Lys Gln Cys Leu Gln Pro
            420                 425                 430         
Pro Glu Ala Thr Leu Arg Ala Gly Glu Leu Ser Phe Phe Thr Arg Thr
        435                 440                 445             
Ala Trp Leu Ala Leu Thr Leu Ala Leu Ala Phe Leu Leu Leu Ile Ser
    450                 455                 460                 
Thr Ala Ala Asn Leu Ser Leu Leu Leu Ser Arg Ala Glu Arg Asn Arg
465                 470                 475                 480 
Arg Leu His Gly Asp Tyr Ala Tyr His Pro Leu Gln Glu Met Asn Gly
                485                 490                 495     
Glu Pro Leu Ala Ala Glu Lys Glu Gln Pro Gly Gly Ala His Asn Pro
            500                 505                 510         
Phe Lys Asp
        515 


<210> 2241
<211> 1321
<212> PRT
<213> Homo sapiens

<400> 2241
Met Asp Ser Ala Gly Asn Lys Leu Ile Ala Pro Ala Val Cys Phe Val
 1               5                  10                  15      
Ile Pro Pro Thr Asp Pro Glu Ala Leu Ala Leu Ala Asp Ser Leu Gly
            20                  25                  30          
Ser Gln Tyr Arg Ser Val Arg Gln Lys Ala Ala Gly Ser Lys Arg Thr
        35                  40                  45              
Leu Gln Gln Arg Tyr Glu Val Leu Lys Thr Glu Asn Pro Gly Asp Ala
    50                  55                  60                  
Ser Asp Leu Gln Gly Arg Gln Leu Leu Ala Gly Leu Asp Lys Val Ala
65                  70                  75                  80  
Ser Asp Leu Asp Arg Gln Glu Lys Ala Ile Thr Gly Ile Leu Arg Pro
                85                  90                  95      
Pro Leu Glu Gln Gly Arg Ala Val Gln Asp Ser Ala Glu Arg Ala Lys
            100                 105                 110         
Asp Leu Lys Asn Ile Thr Asn Glu Leu Leu Arg Ile Glu Pro Glu Lys
        115                 120                 125             
Thr Arg Ser Thr Ala Glu Gly Glu Ala Phe Ile Gln Ala Leu Pro Gly
    130                 135                 140                 
Ser Gly Thr Thr Pro Leu Leu Arg Thr Arg Val Glu Asp Thr Asn Arg
145                 150                 155                 160 
Lys Tyr Glu His Leu Leu Gln Leu Leu Asp Leu Ala Gln Glu Lys Val
                165                 170                 175     
Asp Val Ala Asn Arg Leu Glu Lys Ser Leu Gln Gln Ser Trp Glu Leu
            180                 185                 190         
Leu Ala Thr His Glu Asn His Leu Asn Gln Asp Asp Thr Val Pro Glu
        195                 200                 205             
Ser Ser Arg Val Leu Asp Ser Lys Gly Gln Glu Leu Ala Ala Met Ala
    210                 215                 220                 
Cys Glu Leu Gln Ala Gln Lys Ser Leu Leu Gly Glu Val Glu Gln Asn
225                 230                 235                 240 
Leu Gln Ala Ala Lys Gln Cys Ser Ser Thr Leu Ala Ser Arg Phe Gln
                245                 250                 255     
Glu His Cys Pro Asp Leu Glu Arg Gln Glu Ala Glu Val His Lys Leu
            260                 265                 270         
Gly Gln Arg Phe Asn Asn Leu Arg Gln Gln Val Glu Arg Arg Ala Gln
        275                 280                 285             
Ser Leu Gln Ser Ala Lys Ala Ala Tyr Glu His Phe His Arg Gly His
    290                 295                 300                 
Asp His Val Leu Gln Phe Leu Val Ser Ile Pro Ser Tyr Glu Pro Gln
305                 310                 315                 320 
Glu Thr Asp Ser Leu Ser Gln Met Glu Thr Lys Leu Lys Asn Gln Lys
                325                 330                 335     
Asn Leu Leu Asp Glu Ile Ala Ser Arg Glu Gln Glu Val Gln Lys Ile
            340                 345                 350         
Cys Ala Asn Ser Gln Gln Tyr Gln Gln Ala Val Lys Asp Tyr Glu Leu
        355                 360                 365             
Glu Ala Glu Lys Leu Arg Ser Leu Leu Asp Leu Glu Asn Gly Arg Arg
    370                 375                 380                 
Ser His Val Ser Lys Arg Ala Arg Leu Gln Ser Pro Ala Thr Lys Val
385                 390                 395                 400 
Lys Glu Glu Glu Ala Ala Leu Ala Ala Lys Phe Thr Glu Val Tyr Ala
                405                 410                 415     
Ile Asn Arg Gln Arg Leu Gln Asn Leu Glu Phe Ala Leu Asn Leu Leu
            420                 425                 430         
Arg Gln Gln Pro Glu Val Glu Val Thr His Glu Thr Leu Gln Arg Asn
        435                 440                 445             
Arg Pro Asp Ser Gly Val Glu Glu Ala Trp Lys Ile Arg Lys Glu Leu
    450                 455                 460                 
Asp Glu Glu Thr Glu Arg Arg Arg Gln Leu Glu Asn Glu Val Lys Ser
465                 470                 475                 480 
Thr Gln Glu Glu Ile Trp Thr Leu Arg Asn Gln Gly Pro Gln Glu Ser
                485                 490                 495     
Val Val Arg Lys Glu Val Leu Lys Lys Val Pro Asp Pro Val Leu Glu
            500                 505                 510         
Glu Ser Phe Gln Gln Leu Gln Arg Thr Leu Ala Glu Glu Gln His Lys
        515                 520                 525             
Asn Gln Leu Leu Gln Glu Glu Leu Glu Ala Leu Gln Leu Gln Leu Arg
    530                 535                 540                 
Ala Leu Glu Gln Glu Thr Arg Asp Gly Gly Gln Glu Tyr Val Val Lys
545                 550                 555                 560 
Glu Val Leu Arg Ile Glu Pro Asp Arg Ala Gln Ala Asp Glu Val Leu
                565                 570                 575     
Gln Leu Arg Glu Glu Leu Glu Ala Leu Arg Arg Gln Lys Gly Ala Arg
            580                 585                 590         
Glu Ala Glu Val Leu Leu Leu Gln Gln Arg Val Ala Ala Leu Ala Glu
        595                 600                 605             
Glu Lys Ser Arg Ala Gln Glu Lys Val Thr Glu Lys Glu Val Val Lys
    610                 615                 620                 
Leu Gln Asn Asp Pro Gln Leu Glu Ala Glu Tyr Gln Gln Leu Gln Glu
625                 630                 635                 640 
Asp His Gln Arg Gln Asp Gln Leu Arg Glu Lys Gln Glu Glu Glu Leu
                645                 650                 655     
Ser Phe Leu Gln Asp Lys Leu Lys Arg Leu Glu Lys Glu Arg Ala Met
            660                 665                 670         
Ala Glu Gly Lys Ile Thr Val Lys Glu Val Leu Lys Val Glu Lys Asp
        675                 680                 685             
Ala Ala Thr Glu Arg Glu Val Ser Asp Leu Thr Arg Gln Tyr Glu Asp
    690                 695                 700                 
Glu Ala Ala Lys Ala Arg Ala Ser Gln Arg Glu Lys Thr Glu Leu Leu
705                 710                 715                 720 
Arg Lys Ile Trp Ala Leu Glu Glu Glu Asn Ala Lys Val Val Val Gln
                725                 730                 735     
Glu Lys Val Arg Glu Ile Val Arg Pro Asp Pro Lys Ala Glu Ser Glu
            740                 745                 750         
Val Ala Asn Leu Arg Leu Glu Leu Val Glu Gln Glu Arg Lys Tyr Arg
        755                 760                 765             
Gly Ala Glu Glu Gln Leu Arg Ser Tyr Gln Ser Glu Leu Glu Ala Leu
    770                 775                 780                 
Arg Arg Arg Gly Pro Gln Val Glu Val Lys Glu Val Thr Lys Glu Val
785                 790                 795                 800 
Ile Lys Tyr Lys Thr Asp Pro Glu Met Glu Lys Glu Leu Gln Arg Leu
                805                 810                 815     
Arg Glu Glu Ile Val Asp Lys Thr Arg Leu Ile Glu Arg Cys Asp Leu
            820                 825                 830         
Glu Ile Tyr Gln Leu Lys Lys Glu Ile Gln Ala Leu Lys Asp Thr Lys
        835                 840                 845             
Pro Gln Val Gln Thr Lys Glu Val Val Gln Glu Ile Leu Gln Phe Gln
    850                 855                 860                 
Glu Asp Pro Gln Thr Lys Glu Glu Val Ala Ser Leu Arg Ala Lys Leu
865                 870                 875                 880 
Ser Glu Glu Gln Lys Lys Gln Val Asp Leu Glu Arg Glu Arg Ala Ser
                885                 890                 895     
Gln Glu Glu Gln Ile Ala Arg Lys Glu Glu Glu Leu Ser Arg Val Lys
            900                 905                 910         
Glu Arg Val Val Gln Gln Glu Val Val Arg Tyr Glu Glu Glu Pro Gly
        915                 920                 925             
Leu Arg Ala Glu Ala Ser Ala Phe Ala Glu Ser Ile Asp Val Glu Leu
    930                 935                 940                 
Arg Gln Ile Asp Lys Leu Arg Ala Glu Leu Arg Arg Leu Gln Arg Arg
945                 950                 955                 960 
Arg Thr Glu Leu Glu Arg Gln Leu Glu Glu Leu Glu Arg Glu Arg Gln
                965                 970                 975     
Ala Arg Arg Glu Ala Glu Arg Glu Val Gln Arg Leu Gln Gln Arg Leu
            980                 985                 990         
Ala Ala Leu Glu Gln Glu Glu Ala Glu Ala Arg Glu Lys Val Thr His
        995                 1000                1005            
Thr Gln Lys Val Val Leu Gln Gln Asp Pro Gln Gln Ala Arg Glu His
    1010                1015                1020                
Ala Leu Leu Arg Leu Gln Leu Glu Glu Glu Gln His Arg Arg Gln Leu
1025                1030                1035                1040
Leu Glu Gly Glu Leu Glu Thr Leu Arg Arg Lys Leu Ala Ala Leu Glu
                1045                1050                1055    
Lys Ala Glu Val Lys Glu Lys Val Val Leu Ser Glu Ser Val Gln Val
            1060                1065                1070        
Glu Lys Gly Asp Thr Glu Gln Glu Ile Gln Arg Leu Lys Ser Ser Leu
        1075                1080                1085            
Glu Glu Glu Ser Arg Ser Lys Arg Glu Leu Asp Val Glu Val Ser Arg
    1090                1095                1100                
Leu Glu Ala Arg Leu Ser Glu Leu Glu Phe His Asn Ser Lys Ser Ser
1105                1110                1115                1120
Lys Glu Leu Asp Phe Leu Arg Glu Glu Asn His Lys Leu Gln Leu Glu
                1125                1130                1135    
Arg Gln Asn Leu Gln Leu Glu Thr Arg Arg Leu Gln Ser Glu Ile Asn
            1140                1145                1150        
Met Ala Ala Thr Glu Thr Arg Asp Leu Arg Asn Met Thr Val Ala Asp
        1155                1160                1165            
Ser Gly Thr Asn His Asp Ser Arg Leu Trp Ser Leu Glu Arg Glu Leu
    1170                1175                1180                
Asp Asp Leu Lys Arg Leu Ser Lys Asp Lys Asp Leu Glu Ile Asp Glu
1185                1190                1195                1200
Leu Gln Lys Arg Leu Gly Ser Val Ala Val Lys Arg Glu Gln Arg Glu
                1205                1210                1215    
Asn His Leu Arg Arg Ser Ile Val Val Ile His Pro Asp Thr Gly Arg
            1220                1225                1230        
Glu Leu Ser Pro Glu Glu Ala His Arg Ala Gly Leu Ile Asp Trp Asn
        1235                1240                1245            
Met Phe Val Lys Leu Arg Ser Gln Glu Cys Asp Trp Glu Glu Ile Ser
    1250                1255                1260                
Val Lys Gly Pro Asn Gly Glu Ser Ser Val Ile His Asp Arg Lys Ser
1265                1270                1275                1280
Gly Lys Lys Phe Ser Ile Glu Glu Ala Leu Gln Ser Gly Arg Leu Thr
                1285                1290                1295    
Pro Ala Gln Tyr Asp Arg Tyr Val Asn Lys Asp Met Ser Ile Gln Glu
            1300                1305                1310        
Leu Ala Val Leu Val Ser Gly Gln Lys
        1315                1320    


<210> 2242
<211> 331
<212> PRT
<213> Homo sapiens

<400> 2242
Met Ala Val Ser Phe Leu Gln Leu His Pro Arg Glu Asp Ala Cys Ile
 1               5                  10                  15      
Pro Asn Thr Asn Tyr Gly Val Leu Leu Ile Glu Phe Phe Glu Leu Tyr
            20                  25                  30          
Gly Arg His Phe Asn Tyr Leu Lys Thr Gly Ile Arg Ile Lys Asp Gly
        35                  40                  45              
Gly Ser Tyr Val Ala Lys Asp Glu Val Gln Lys Asn Met Leu Asp Gly
    50                  55                  60                  
Tyr Arg Pro Ser Met Leu Tyr Ile Glu Asp Pro Leu Gln Pro Gly Asn
65                  70                  75                  80  
Asp Val Gly Arg Ser Ser Tyr Gly Ala Met Gln Val Lys Gln Ala Phe
                85                  90                  95      
Asp Tyr Ala Tyr Val Val Leu Ser His Ala Val Ser Pro Ile Ala Lys
            100                 105                 110         
Tyr Tyr Pro Asn Asn Glu Thr Glu Ser Ile Leu Gly Arg Ile Ile Arg
        115                 120                 125             
Val Thr Asp Glu Val Ala Thr Tyr Arg Asp Trp Ile Ser Lys Gln Trp
    130                 135                 140                 
Gly Leu Lys Asn Arg Pro Glu Pro Ser Cys Asn Gly Asn Gly Val Thr
145                 150                 155                 160 
Leu Ile Val Asp Thr Gln Gln Leu Asp Lys Cys Asn Asn Asn Leu Ser
                165                 170                 175     
Glu Glu Asn Glu Ala Leu Gly Lys Cys Arg Ser Lys Thr Ser Glu Ser
            180                 185                 190         
Leu Ser Lys His Ser Ser Asn Ser Ser Ser Gly Pro Val Ser Ser Ser
        195                 200                 205             
Ser Ala Thr Gln Ser Ser Ser Ser Asp Val Asp Ser Asp Ala Thr Pro
    210                 215                 220                 
Cys Lys Thr Pro Lys Gln Leu Leu Cys Arg Pro Ser Thr Gly Asn Arg
225                 230                 235                 240 
Val Gly Ser Gln Asp Val Ser Leu Glu Ser Ser Gln Ala Val Gly Lys
                245                 250                 255     
Met Gln Ser Thr Gln Thr Thr Asn Thr Ser Asn Ser Thr Asn Lys Ser
            260                 265                 270         
Gln His Gly Ser Ala Arg Leu Phe Arg Ser Ser Ser Lys Gly Phe Gln
        275                 280                 285             
Gly Thr Thr Gln Thr Ser His Gly Ser Leu Met Thr Asn Lys Gln His
    290                 295                 300                 
Gln Gly Lys Ser Asn Asn Gln Tyr Tyr His Gly Lys Lys Arg Lys His
305                 310                 315                 320 
Lys Arg Asp Ala Pro Leu Ser Asp Leu Cys Arg
                325                 330     


<210> 2243
<211> 1019
<212> PRT
<213> Homo sapiens

<400> 2243
Met Gly Ser Lys Arg Gly Ile Ser Ser Arg His His Ser Leu Ser Ser
 1               5                  10                  15      
Tyr Glu Ile Met Phe Ala Ala Leu Phe Ala Ile Leu Val Val Leu Cys
            20                  25                  30          
Ala Gly Leu Ile Ala Val Ser Cys Leu Thr Ile Lys Glu Ser Gln Arg
        35                  40                  45              
Gly Ala Ala Leu Gly Gln Ser His Glu Ala Arg Ala Thr Phe Lys Ile
    50                  55                  60                  
Thr Ser Gly Val Thr Tyr Asn Pro Asn Leu Gln Asp Lys Leu Ser Val
65                  70                  75                  80  
Asp Phe Lys Val Leu Ala Phe Asp Leu Gln Gln Met Ile Asp Glu Ile
                85                  90                  95      
Phe Leu Ser Ser Asn Leu Lys Asn Glu Tyr Lys Asn Ser Arg Val Leu
            100                 105                 110         
Gln Phe Glu Asn Gly Ser Ile Ile Val Val Phe Asp Leu Phe Phe Ala
        115                 120                 125             
Gln Trp Val Ser Asp Glu Asn Val Lys Glu Glu Leu Ile Gln Gly Leu
    130                 135                 140                 
Glu Ala Asn Lys Ser Ser Gln Leu Val Thr Phe His Ile Asp Leu Asn
145                 150                 155                 160 
Ser Val Asp Ile Leu Asp Lys Leu Thr Thr Thr Ser His Leu Ala Thr
                165                 170                 175     
Pro Gly Asn Val Ser Ile Glu Cys Leu Pro Gly Ser Ser Pro Cys Thr
            180                 185                 190         
Asp Ala Leu Thr Cys Ile Lys Ala Asp Leu Phe Cys Asp Gly Glu Val
        195                 200                 205             
Asn Cys Pro Asp Gly Ser Asp Glu Asp Asn Lys Met Cys Ala Thr Val
    210                 215                 220                 
Cys Asp Gly Arg Phe Leu Leu Thr Gly Ser Ser Gly Ser Phe Gln Ala
225                 230                 235                 240 
Thr His Tyr Pro Lys Pro Ser Glu Thr Ser Val Val Cys Gln Trp Ile
                245                 250                 255     
Ile Arg Val Asn Gln Gly Leu Ser Ile Lys Leu Ser Phe Asp Asp Phe
            260                 265                 270         
Asn Thr Tyr Tyr Thr Asp Ile Leu Asp Ile Tyr Glu Gly Val Gly Ser
        275                 280                 285             
Ser Lys Ile Leu Arg Ala Ser Ile Trp Glu Thr Asn Pro Gly Thr Ile
    290                 295                 300                 
Arg Ile Phe Ser Asn Gln Val Thr Ala Thr Phe Leu Ile Glu Ser Asp
305                 310                 315                 320 
Glu Ser Asp Tyr Val Gly Phe Asn Ala Thr Tyr Thr Ala Phe Asn Ser
                325                 330                 335     
Ser Glu Leu Asn Asn Tyr Glu Lys Ile Asn Cys Asn Phe Glu Asp Gly
            340                 345                 350         
Phe Cys Phe Trp Val Gln Asp Leu Asn Asp Asp Asn Glu Trp Glu Arg
        355                 360                 365             
Ile Gln Gly Ser Thr Phe Ser Pro Phe Thr Gly Pro Asn Phe Asp His
    370                 375                 380                 
Thr Phe Gly Asn Ala Ser Gly Phe Tyr Ile Ser Thr Pro Thr Gly Pro
385                 390                 395                 400 
Gly Gly Arg Gln Glu Arg Val Gly Leu Leu Ser Leu Pro Leu Asp Pro
                405                 410                 415     
Thr Leu Glu Pro Ala Cys Leu Ser Phe Trp Tyr His Met Tyr Gly Glu
            420                 425                 430         
Asn Val His Lys Leu Ser Ile Asn Ile Ser Asn Asp Gln Asn Met Glu
        435                 440                 445             
Lys Thr Val Phe Gln Lys Glu Gly Asn Tyr Gly Asp Asn Trp Asn Tyr
    450                 455                 460                 
Gly Gln Val Thr Leu Asn Glu Thr Val Lys Phe Lys Val Ala Phe Asn
465                 470                 475                 480 
Ala Phe Lys Asn Lys Ile Leu Ser Asp Ile Ala Leu Asp Asp Ile Ser
                485                 490                 495     
Leu Thr Tyr Gly Ile Cys Asn Gly Ser Leu Tyr Pro Glu Pro Thr Leu
            500                 505                 510         
Val Pro Thr Pro Pro Pro Glu Leu Pro Thr Asp Cys Gly Gly Pro Phe
        515                 520                 525             
Glu Leu Trp Glu Pro Asn Thr Thr Phe Ser Ser Thr Asn Phe Pro Asn
    530                 535                 540                 
Ser Tyr Pro Asn Leu Ala Phe Cys Val Trp Ile Leu Asn Ala Gln Lys
545                 550                 555                 560 
Gly Lys Asn Ile Gln Leu His Phe Gln Glu Phe Asp Leu Glu Asn Ile
                565                 570                 575     
Asn Asp Val Val Glu Ile Arg Asp Gly Glu Glu Ala Asp Ser Leu Leu
            580                 585                 590         
Leu Ala Val Tyr Thr Gly Pro Gly Pro Val Lys Asp Val Phe Ser Thr
        595                 600                 605             
Thr Asn Arg Met Thr Val Leu Leu Ile Thr Asn Asp Val Leu Ala Arg
    610                 615                 620                 
Gly Gly Phe Lys Ala Asn Phe Thr Thr Gly Tyr His Leu Gly Ile Pro
625                 630                 635                 640 
Glu Pro Cys Lys Ala Asp His Phe Gln Cys Lys Asn Gly Glu Cys Val
                645                 650                 655     
Pro Leu Val Asn Leu Cys Asp Gly His Leu His Cys Glu Asp Gly Ser
            660                 665                 670         
Asp Glu Ala Asp Cys Val Arg Phe Phe Asn Gly Thr Thr Asn Asn Asn
        675                 680                 685             
Gly Leu Val Arg Phe Arg Ile Gln Ser Ile Trp His Thr Ala Cys Ala
    690                 695                 700                 
Glu Asn Trp Thr Thr Gln Ile Ser Asn Asp Val Cys Gln Leu Leu Gly
705                 710                 715                 720 
Leu Gly Ser Gly Asn Ser Ser Lys Pro Ile Phe Pro Thr Asp Gly Gly
                725                 730                 735     
Pro Phe Val Lys Leu Asn Thr Ala Pro Asp Gly His Leu Ile Leu Thr
            740                 745                 750         
Pro Ser Gln Gln Cys Leu Gln Asp Ser Leu Ile Arg Leu Gln Cys Asn
        755                 760                 765             
His Lys Ser Cys Gly Lys Lys Leu Ala Ala Gln Asp Ile Thr Pro Lys
    770                 775                 780                 
Ile Val Gly Gly Ser Asn Ala Lys Glu Gly Ala Trp Pro Trp Val Val
785                 790                 795                 800 
Gly Leu Tyr Tyr Gly Gly Arg Leu Leu Cys Gly Ala Ser Leu Val Ser
                805                 810                 815     
Ser Asp Trp Leu Val Ser Ala Ala His Cys Val Tyr Gly Arg Asn Leu
            820                 825                 830         
Glu Pro Ser Lys Trp Thr Ala Ile Leu Gly Leu His Met Lys Ser Asn
        835                 840                 845             
Leu Thr Ser Pro Gln Thr Val Pro Arg Leu Ile Asp Glu Ile Val Ile
    850                 855                 860                 
Asn Pro His Tyr Asn Arg Arg Arg Lys Asp Asn Asp Ile Ala Met Met
865                 870                 875                 880 
His Leu Glu Phe Lys Val Asn Tyr Thr Asp Tyr Ile Gln Pro Ile Cys
                885                 890                 895     
Leu Pro Glu Glu Asn Gln Val Phe Pro Pro Gly Arg Asn Cys Ser Ile
            900                 905                 910         
Ala Gly Trp Gly Thr Val Val Tyr Gln Gly Thr Thr Ala Asn Ile Leu
        915                 920                 925             
Gln Glu Ala Asp Val Pro Leu Leu Ser Asn Glu Arg Cys Gln Gln Gln
    930                 935                 940                 
Met Pro Glu Tyr Asn Ile Thr Glu Asn Met Ile Cys Ala Gly Tyr Glu
945                 950                 955                 960 
Glu Gly Gly Ile Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Met
                965                 970                 975     
Cys Gln Glu Asn Asn Arg Trp Phe Leu Ala Gly Val Thr Ser Phe Gly
            980                 985                 990         
Tyr Lys Cys Ala Leu Pro Asn Arg Pro Gly Val Tyr Ala Arg Val Ser
        995                 1000                1005            
Arg Phe Thr Glu Trp Ile Gln Ser Phe Leu His
    1010                1015                


<210> 2244
<211> 100
<212> PRT
<213> Homo sapiens

<400> 2244
Met Ala Thr Gly Asp Leu Gly Asp Pro Gly Ala Ser Val Leu Ala His
 1               5                  10                  15      
Val Glu Glu Glu Cys Ser Leu Pro Ile Val Thr Val Ile Thr Leu Leu
            20                  25                  30          
Pro Glu Thr Thr Asp Ala Thr Ala Gln Gly Arg Gly Pro Ser Thr Ala
        35                  40                  45              
Pro Ala Val Ser Cys Pro Ala His Pro Met Val Asn His Phe Val Met
    50                  55                  60                  
Asn Ser Val Arg Pro Lys Met Ala Ile Ser Leu Met Gln Lys Glu Ser
65                  70                  75                  80  
Lys Leu Leu Trp Asn Gly Phe Pro Asn Met Gln Val Ser Cys Gln Arg
                85                  90                  95      
Met Cys Ala Ser
            100 


<210> 2245
<211> 1244
<212> PRT
<213> Homo sapiens

<400> 2245
Met Val Asn Phe Asp Tyr His Gln Met Val Lys Gly Gly Lys Ala Glu
 1               5                  10                  15      
Lys Leu His Ser Val Leu Lys Pro Gln Val Gln Lys Phe Leu Asp Tyr
            20                  25                  30          
Gly Phe Phe Tyr Phe Asn Gly Ser Glu Val Gln Arg Cys Gln Ser Gly
        35                  40                  45              
Thr Val Arg Thr Asn Cys Leu Asp Cys Leu Asp Arg Thr Asn Ser Val
    50                  55                  60                  
Gln Ala Phe Leu Gly Leu Glu Met Leu Ala Lys Gln Leu Glu Ala Leu
65                  70                  75                  80  
Gly Leu Ala Glu Lys Pro Gln Leu Val Thr Arg Phe Gln Glu Val Phe
                85                  90                  95      
Arg Ser Met Trp Ser Val Asn Gly Asp Ser Ile Ser Lys Ile Tyr Ala
            100                 105                 110         
Gly Thr Gly Ala Leu Glu Gly Lys Ala Lys Leu Lys Asp Gly Ala Arg
        115                 120                 125             
Ser Val Thr Arg Thr Ile Gln Asn Asn Phe Phe Asp Ser Ser Lys Gln
    130                 135                 140                 
Glu Ala Ile Asp Val Leu Leu Leu Gly Asn Thr Leu Asn Ser Asp Leu
145                 150                 155                 160 
Ala Asp Lys Ala Arg Ala Leu Leu Thr Thr Gly Ser Leu Arg Val Ser
                165                 170                 175     
Glu Gln Thr Leu Gln Ser Ala Ser Ser Lys Val Leu Lys Ser Met Cys
            180                 185                 190         
Glu Asn Phe Tyr Lys Tyr Ser Lys Pro Lys Lys Ile Arg Val Cys Val
        195                 200                 205             
Gly Thr Trp Asn Val Asn Gly Gly Lys Gln Phe Arg Ser Ile Ala Phe
    210                 215                 220                 
Lys Asn Gln Thr Leu Thr Asp Trp Leu Leu Asp Ala Pro Lys Leu Ala
225                 230                 235                 240 
Gly Ile Gln Glu Phe Gln Asp Lys Arg Ser Lys Pro Thr Asp Ile Phe
                245                 250                 255     
Ala Ile Gly Phe Glu Glu Met Val Glu Leu Asn Ala Gly Asn Ile Val
            260                 265                 270         
Ser Ala Ser Thr Thr Asn Gln Lys Leu Trp Ala Val Glu Leu Gln Lys
        275                 280                 285             
Thr Ile Ser Arg Asp Asn Lys Tyr Val Leu Leu Ala Ser Glu Gln Leu
    290                 295                 300                 
Val Gly Val Cys Leu Phe Val Phe Ile Arg Pro Gln His Ala Pro Phe
305                 310                 315                 320 
Ile Arg Asp Val Ala Val Asp Thr Val Lys Thr Gly Met Gly Gly Ala
                325                 330                 335     
Thr Gly Asn Lys Gly Ala Val Ala Ile Arg Met Leu Phe His Thr Thr
            340                 345                 350         
Ser Leu Cys Phe Val Cys Ser His Phe Ala Ala Gly Gln Ser Gln Val
        355                 360                 365             
Lys Glu Arg Asn Glu Asp Phe Ile Glu Ile Ala Arg Lys Leu Ser Phe
    370                 375                 380                 
Pro Met Gly Arg Met Leu Phe Ser His Asp Tyr Val Phe Trp Cys Gly
385                 390                 395                 400 
Asp Phe Asn Tyr Arg Ile Asp Leu Pro Asn Glu Glu Val Lys Glu Leu
                405                 410                 415     
Ile Arg Gln Gln Asn Trp Asp Ser Leu Ile Ala Gly Asp Gln Leu Ile
            420                 425                 430         
Asn Gln Lys Asn Ala Gly Gln Val Phe Arg Gly Phe Leu Glu Gly Lys
        435                 440                 445             
Val Thr Phe Ala Pro Thr Tyr Lys Tyr Asp Leu Phe Ser Asp Asp Tyr
    450                 455                 460                 
Asp Thr Ser Glu Lys Cys Arg Thr Pro Ala Trp Thr Asp Arg Val Leu
465                 470                 475                 480 
Trp Arg Arg Arg Lys Trp Pro Phe Asp Arg Ser Ala Glu Asp Leu Asp
                485                 490                 495     
Leu Leu Asn Ala Ser Phe Gln Asp Glu Ser Lys Ile Leu Tyr Thr Trp
            500                 505                 510         
Thr Pro Gly Thr Leu Leu His Tyr Gly Arg Ala Glu Leu Lys Thr Ser
        515                 520                 525             
Asp His Arg Pro Val Val Ala Leu Ile Asp Ile Asp Ile Phe Glu Val
    530                 535                 540                 
Glu Ala Glu Glu Arg Gln Asn Ile Tyr Lys Glu Val Ile Ala Val Gln
545                 550                 555                 560 
Gly Pro Pro Asp Gly Thr Val Leu Val Ser Ile Lys Ser Ser Leu Pro
                565                 570                 575     
Glu Asn Asn Phe Phe Asp Asp Ala Leu Ile Asp Glu Leu Leu Gln Gln
            580                 585                 590         
Phe Ala Ser Phe Gly Glu Val Ile Leu Ile Arg Phe Val Glu Asp Lys
        595                 600                 605             
Met Trp Val Thr Phe Leu Glu Gly Ser Ser Ala Leu Asn Val Leu Ser
    610                 615                 620                 
Leu Asn Gly Lys Glu Leu Leu Asn Arg Thr Ile Thr Ile Ala Leu Lys
625                 630                 635                 640 
Ser Pro Asp Trp Ile Lys Asn Leu Glu Glu Glu Met Ser Leu Glu Lys
                645                 650                 655     
Ile Ser Ile Ala Leu Pro Ser Ser Thr Ser Ser Thr Leu Leu Gly Glu
            660                 665                 670         
Asp Ala Glu Val Ala Ala Asp Phe Asp Met Glu Gly Asp Val Asp Asp
        675                 680                 685             
Tyr Ser Ala Glu Val Glu Glu Leu Leu Pro Gln His Leu Gln Pro Ser
    690                 695                 700                 
Ser Ser Ser Gly Leu Gly Thr Ser Pro Ser Ser Ser Pro Arg Thr Ser
705                 710                 715                 720 
Pro Cys Gln Ser Pro Thr Ile Ser Glu Gly Pro Val Pro Ser Leu Pro
                725                 730                 735     
Ile Arg Pro Ser Arg Ala Pro Ser Arg Thr Pro Gly Pro Pro Ser Ala
            740                 745                 750         
Gln Ser Ser Pro Ile Asp Ala Gln Pro Ala Thr Pro Leu Pro Gln Lys
        755                 760                 765             
Asp Pro Ala Gln Pro Leu Glu Pro Lys Arg Pro Pro Pro Pro Arg Pro
    770                 775                 780                 
Val Ala Pro Pro Thr Arg Pro Ala Pro Pro Gln Arg Pro Pro Pro Pro
785                 790                 795                 800 
Ser Gly Ala Arg Ser Pro Ala Pro Thr Arg Lys Glu Phe Gly Gly Ile
                805                 810                 815     
Gly Ala Pro Pro Ser Pro Gly Val Ala Arg Arg Glu Met Glu Ala Pro
            820                 825                 830         
Lys Ser Pro Gly Thr Thr Arg Lys Asp Asn Ile Gly Arg Ser Gln Pro
        835                 840                 845             
Ser Pro Gln Ala Gly Leu Ala Gly Pro Gly Pro Ala Gly Tyr Ser Thr
    850                 855                 860                 
Ala Arg Pro Thr Ile Pro Pro Arg Ala Gly Val Ile Ser Ala Pro Gln
865                 870                 875                 880 
Ser His Ala Arg Ala Ser Ala Gly Arg Leu Thr Pro Glu Ser Gln Ser
                885                 890                 895     
Lys Thr Ser Glu Thr Ser Lys Gly Ser Thr Phe Leu Pro Glu Pro Leu
            900                 905                 910         
Lys Pro Gln Ala Ala Phe Pro Pro Gln Ser Ser Leu Pro Pro Pro Ala
        915                 920                 925             
Gln Arg Leu Gln Glu Pro Leu Val Pro Val Ala Ala Pro Met Pro Gln
    930                 935                 940                 
Ser Gly Pro Gln Pro Asn Leu Glu Thr Pro Pro Gln Pro Pro Pro Arg
945                 950                 955                 960 
Ser Arg Ser Ser His Ser Leu Pro Ser Glu Ala Ser Ser Gln Pro Gln
                965                 970                 975     
Val Lys Thr Asn Gly Ile Ser Asp Gly Lys Arg Glu Ser Pro Leu Lys
            980                 985                 990         
Ile Asp Pro Phe Glu Asp Leu Ser Phe Asn Leu Leu Ala Val Ser Lys
        995                 1000                1005            
Ala Gln Leu Ser Val Gln Thr Ser Pro Val Pro Thr Pro Asp Pro Lys
    1010                1015                1020                
Arg Leu Ile Gln Leu Pro Ser Ala Thr Gln Ser Asn Val Leu Ser Ser
1025                1030                1035                1040
Val Ser Cys Met Pro Thr Met Pro Pro Ile Pro Ala Arg Ser Gln Ser
                1045                1050                1055    
Gln Glu Asn Met Arg Ser Ser Pro Asn Pro Phe Ile Thr Gly Leu Thr
            1060                1065                1070        
Arg Thr Asn Pro Phe Ser Asp Arg Thr Ala Ala Pro Gly Asn Pro Phe
        1075                1080                1085            
Arg Ala Lys Ser Glu Glu Ser Glu Ala Thr Ser Trp Phe Ser Lys Glu
    1090                1095                1100                
Glu Pro Val Thr Ile Ser Pro Phe Pro Ser Leu Gln Pro Leu Gly His
1105                1110                1115                1120
Asn Lys Ser Arg Ala Ser Ser Ser Leu Asp Gly Phe Lys Asp Ser Phe
                1125                1130                1135    
Asp Leu Gln Gly Gln Ser Thr Leu Lys Ile Ser Asn Pro Lys Gly Trp
            1140                1145                1150        
Val Thr Phe Glu Glu Glu Glu Asp Phe Gly Val Lys Gly Lys Ser Lys
        1155                1160                1165            
Ser Ala Cys Ser Asp Leu Leu Gly Asn Gln Pro Ser Ser Phe Ser Gly
    1170                1175                1180                
Ser Asn Leu Thr Leu Asn Asp Asp Trp Asn Lys Gly Thr Asn Val Ser
1185                1190                1195                1200
Phe Cys Val Leu Pro Ser Arg Arg Pro Pro Pro Pro Pro Val Pro Leu
                1205                1210                1215    
Leu Pro Pro Gly Thr Ser Pro Pro Val Asp Pro Phe Thr Thr Leu Ala
            1220                1225                1230        
Ser Lys Ala Ser Pro Thr Leu Asp Phe Thr Glu Arg
        1235                1240                


<210> 2246
<211> 1459
<212> PRT
<213> Homo sapiens

<400> 2246
Met Asn Leu Ser Asp Ile Asp Gln Asp Gly Lys Leu Thr Ala Glu Glu
 1               5                  10                  15      
Phe Ile Leu Ala Met His Leu Ile Asp Val Ala Met Ser Gly Gln Pro
            20                  25                  30          
Leu Pro Pro Val Leu Pro Pro Glu Tyr Ile Pro Pro Ser Phe Arg Arg
        35                  40                  45              
Val Arg Ser Gly Ser Gly Ile Ser Val Ile Ser Ser Thr Ser Val Asp
    50                  55                  60                  
Gln Arg Leu Pro Glu Glu Pro Val Leu Glu Asp Glu Gln Gln Gln Leu
65                  70                  75                  80  
Glu Lys Lys Leu Pro Val Thr Phe Glu Asp Lys Lys Arg Glu Asn Phe
                85                  90                  95      
Glu Arg Gly Asn Leu Glu Leu Glu Lys Arg Arg Gln Ala Leu Leu Glu
            100                 105                 110         
Gln Gln Arg Lys Glu Gln Glu Arg Leu Ala Gln Leu Glu Arg Ala Glu
        115                 120                 125             
Gln Glu Arg Lys Glu Arg Glu Arg Gln Glu Gln Glu Arg Lys Arg Gln
    130                 135                 140                 
Leu Glu Leu Glu Lys Gln Leu Glu Lys Gln Arg Glu Leu Glu Arg Gln
145                 150                 155                 160 
Arg Glu Glu Glu Arg Arg Lys Glu Ile Glu Arg Arg Glu Ala Ala Lys
                165                 170                 175     
Arg Glu Leu Glu Arg Gln Arg Gln Leu Glu Trp Glu Arg Asn Arg Arg
            180                 185                 190         
Gln Glu Leu Leu Asn Gln Arg Asn Lys Glu Gln Glu Asp Ile Val Val
        195                 200                 205             
Leu Lys Ala Lys Lys Lys Thr Leu Glu Phe Glu Leu Glu Ala Leu Asn
    210                 215                 220                 
Asp Lys Lys His Gln Leu Glu Gly Lys Leu Gln Asp Ile Arg Cys Arg
225                 230                 235                 240 
Leu Thr Thr Gln Arg Gln Glu Ile Glu Ser Thr Asn Lys Ser Arg Glu
                245                 250                 255     
Leu Arg Ile Ala Glu Ile Thr His Leu Gln Gln Gln Leu Gln Glu Ser
            260                 265                 270         
Gln Gln Met Leu Gly Arg Leu Ile Pro Glu Lys Gln Ile Leu Asn Asp
        275                 280                 285             
Gln Leu Lys Gln Val Gln Gln Asn Ser Leu His Arg Asp Ser Leu Val
    290                 295                 300                 
Thr Leu Lys Arg Ala Leu Glu Ala Lys Glu Leu Ala Arg Gln His Leu
305                 310                 315                 320 
Arg Asp Gln Leu Asp Glu Val Glu Lys Glu Thr Arg Ser Lys Leu Gln
                325                 330                 335     
Glu Ile Asp Ile Phe Asn Asn Gln Leu Lys Glu Leu Arg Glu Ile His
            340                 345                 350         
Asn Lys Gln Gln Leu Gln Lys Gln Lys Ser Met Glu Ala Glu Arg Leu
        355                 360                 365             
Lys Gln Lys Glu Gln Glu Arg Lys Ile Ile Glu Leu Glu Lys Gln Lys
    370                 375                 380                 
Glu Glu Ala Gln Arg Arg Ala Gln Glu Arg Asp Lys Gln Trp Leu Glu
385                 390                 395                 400 
His Val Gln Gln Glu Asp Glu His Gln Arg Pro Arg Lys Leu His Glu
                405                 410                 415     
Glu Glu Lys Leu Lys Arg Glu Glu Ser Val Lys Lys Lys Asp Gly Glu
            420                 425                 430         
Glu Lys Gly Lys Gln Glu Ala Gln Asp Lys Leu Gly Arg Leu Phe His
        435                 440                 445             
Gln His Gln Glu Pro Ala Lys Pro Ala Val Gln Ala Pro Trp Ser Thr
    450                 455                 460                 
Ala Glu Lys Gly Pro Leu Thr Ile Ser Ala Gln Glu Asn Val Lys Val
465                 470                 475                 480 
Val Tyr Tyr Arg Ala Leu Tyr Pro Phe Glu Ser Arg Ser His Asp Glu
                485                 490                 495     
Ile Thr Ile Gln Pro Gly Asp Ile Val Met Val Lys Gly Glu Trp Val
            500                 505                 510         
Asp Glu Ser Gln Thr Gly Glu Pro Gly Trp Leu Gly Gly Glu Leu Lys
        515                 520                 525             
Gly Lys Thr Gly Trp Phe Pro Ala Asn Tyr Ala Glu Lys Ile Pro Glu
    530                 535                 540                 
Asn Glu Val Pro Ala Pro Val Lys Pro Val Thr Asp Ser Thr Ser Ala
545                 550                 555                 560 
Pro Ala Pro Lys Leu Ala Leu Arg Glu Thr Pro Ala Pro Leu Ala Val
                565                 570                 575     
Thr Ser Ser Glu Pro Ser Thr Thr Pro Asn Asn Trp Ala Asp Phe Ser
            580                 585                 590         
Ser Thr Trp Pro Thr Ser Thr Asn Glu Lys Pro Glu Thr Asp Asn Trp
        595                 600                 605             
Asp Ala Trp Ala Ala Gln Pro Ser Leu Thr Val Pro Ser Ala Gly Gln
    610                 615                 620                 
Leu Arg Gln Arg Ser Ala Phe Thr Pro Ala Thr Ala Thr Gly Ser Ser
625                 630                 635                 640 
Pro Ser Pro Val Leu Gly Gln Gly Glu Lys Val Glu Gly Leu Gln Ala
                645                 650                 655     
Gln Ala Leu Tyr Pro Trp Arg Ala Lys Lys Asp Asn His Leu Asn Phe
            660                 665                 670         
Asn Lys Asn Asp Val Ile Thr Val Leu Glu Gln Gln Asp Met Trp Trp
        675                 680                 685             
Phe Gly Glu Val Gln Gly Gln Lys Gly Trp Phe Pro Lys Ser Tyr Val
    690                 695                 700                 
Lys Leu Ile Ser Gly Pro Ile Arg Lys Ser Thr Ser Met Asp Ser Gly
705                 710                 715                 720 
Ser Ser Glu Ser Pro Ala Ser Leu Lys Arg Val Ala Ser Pro Ala Ala
                725                 730                 735     
Lys Pro Val Val Ser Gly Glu Glu Phe Ile Ala Met Tyr Thr Tyr Glu
            740                 745                 750         
Ser Ser Glu Gln Gly Asp Leu Thr Phe Gln Gln Gly Asp Val Ile Leu
        755                 760                 765             
Val Thr Lys Lys Asp Gly Asp Trp Trp Thr Gly Thr Val Gly Asp Lys
    770                 775                 780                 
Ala Gly Val Phe Pro Ser Asn Tyr Val Arg Leu Lys Asp Ser Glu Gly
785                 790                 795                 800 
Ser Gly Thr Ala Gly Lys Thr Gly Ser Leu Gly Lys Lys Pro Glu Ile
                805                 810                 815     
Ala Gln Val Ile Ala Ser Tyr Thr Ala Thr Gly Pro Glu Gln Leu Thr
            820                 825                 830         
Leu Ala Pro Gly Gln Leu Ile Leu Ile Arg Lys Lys Asn Pro Gly Gly
        835                 840                 845             
Trp Trp Glu Gly Glu Leu Gln Ala Arg Gly Lys Lys Arg Gln Ile Gly
    850                 855                 860                 
Trp Phe Pro Ala Asn Tyr Val Lys Leu Leu Ser Pro Gly Thr Ser Lys
865                 870                 875                 880 
Ile Thr Pro Thr Glu Pro Pro Lys Ser Thr Ala Leu Ala Ala Val Cys
                885                 890                 895     
Gln Val Ile Gly Met Tyr Asp Tyr Thr Ala Gln Asn Asp Asp Glu Leu
            900                 905                 910         
Ala Phe Asn Lys Gly Gln Ile Ile Asn Val Leu Asn Lys Glu Asp Pro
        915                 920                 925             
Asp Trp Trp Lys Gly Glu Val Asn Gly Gln Val Gly Leu Phe Pro Ser
    930                 935                 940                 
Asn Tyr Val Lys Leu Thr Thr Asp Met Asp Pro Ser Gln Gln Trp Cys
945                 950                 955                 960 
Ser Asp Leu His Leu Leu Asp Met Leu Thr Pro Thr Glu Arg Lys Arg
                965                 970                 975     
Gln Gly Tyr Ile His Glu Leu Ile Val Thr Glu Glu Asn Tyr Val Asn
            980                 985                 990         
Asp Leu Gln Leu Val Thr Glu Ile Phe Gln Lys Pro Leu Met Glu Ser
        995                 1000                1005            
Glu Leu Leu Thr Glu Lys Glu Val Ala Met Ile Phe Val Asn Trp Lys
    1010                1015                1020                
Glu Leu Ile Met Cys Asn Ile Lys Leu Leu Lys Ala Leu Arg Val Arg
1025                1030                1035                1040
Lys Lys Met Ser Gly Glu Lys Met Pro Val Lys Met Ile Gly Asp Ile
                1045                1050                1055    
Leu Ser Ala Gln Leu Pro His Met Gln Pro Tyr Ile Arg Phe Cys Ser
            1060                1065                1070        
Arg Gln Leu Asn Gly Ala Ala Leu Ile Gln Gln Lys Thr Asp Glu Ala
        1075                1080                1085            
Pro Asp Phe Lys Glu Phe Val Lys Arg Leu Ala Met Asp Pro Arg Cys
    1090                1095                1100                
Lys Gly Met Pro Leu Ser Ser Phe Ile Leu Lys Pro Met Gln Arg Val
1105                1110                1115                1120
Thr Arg Tyr Pro Leu Ile Ile Lys Asn Ile Leu Glu Asn Thr Pro Glu
                1125                1130                1135    
Asn His Pro Asp His Ser His Leu Lys His Ala Leu Glu Lys Ala Glu
            1140                1145                1150        
Glu Leu Cys Ser Gln Val Asn Glu Gly Val Arg Glu Lys Glu Asn Ser
        1155                1160                1165            
Asp Arg Leu Glu Trp Ile Gln Ala His Val Gln Cys Glu Gly Leu Ser
    1170                1175                1180                
Glu Gln Leu Val Phe Asn Ser Val Thr Asn Cys Leu Gly Pro Arg Lys
1185                1190                1195                1200
Phe Leu His Ser Gly Lys Leu Tyr Lys Ala Lys Ser Asn Lys Glu Leu
                1205                1210                1215    
Tyr Gly Phe Leu Phe Asn Asp Phe Leu Leu Leu Thr Gln Ile Thr Lys
            1220                1225                1230        
Pro Leu Gly Ser Ser Gly Thr Asp Lys Val Phe Ser Pro Lys Ser Asn
        1235                1240                1245            
Leu Gln Tyr Lys Met Tyr Lys Thr Pro Ile Phe Leu Asn Glu Val Leu
    1250                1255                1260                
Val Lys Leu Pro Thr Asp Pro Ser Gly Asp Glu Pro Ile Phe His Ile
1265                1270                1275                1280
Ser His Ile Asp Arg Val Tyr Thr Leu Arg Ala Glu Ser Ile Asn Glu
                1285                1290                1295    
Arg Thr Ala Trp Val Gln Lys Ile Lys Ala Ala Ser Glu Leu Tyr Ile
            1300                1305                1310        
Glu Thr Glu Lys Lys Lys Arg Glu Lys Ala Tyr Leu Val Arg Ser Gln
        1315                1320                1325            
Arg Ala Thr Gly Ile Gly Arg Leu Met Val Asn Val Val Glu Gly Ile
    1330                1335                1340                
Glu Leu Lys Pro Cys Arg Ser His Gly Lys Ser Asn Pro Tyr Cys Glu
1345                1350                1355                1360
Val Thr Met Gly Ser Gln Cys His Ile Thr Lys Thr Ile Gln Asp Thr
                1365                1370                1375    
Leu Asn Pro Lys Trp Asn Ser Asn Cys Gln Phe Phe Ile Arg Asp Leu
            1380                1385                1390        
Glu Gln Glu Val Leu Cys Ile Thr Val Phe Glu Arg Asp Gln Phe Ser
        1395                1400                1405            
Pro Asp Asp Phe Leu Gly Arg Thr Glu Ile Arg Val Ala Asp Ile Lys
    1410                1415                1420                
Lys Asp Gln Gly Ser Lys Gly Pro Val Thr Lys Cys Leu Leu Leu His
1425                1430                1435                1440
Glu Val Pro Thr Gly Glu Ile Val Val Arg Leu Asp Leu Gln Leu Phe
                1445                1450                1455    
Asp Glu Pro
            


<210> 2247
<211> 268
<212> PRT
<213> Homo sapiens

<400> 2247
Met Ala Ala Val Arg Val Leu Val Ala Ser Arg Leu Ala Ala Ala Ser
 1               5                  10                  15      
Ala Phe Thr Ser Leu Ser Pro Gly Gly Arg Thr Pro Ser Gln Arg Ala
            20                  25                  30          
Ala Leu His Leu Ser Val Pro Arg Pro Ala Ala Arg Val Ala Leu Val
        35                  40                  45              
Leu Ser Gly Cys Gly Val Tyr Asp Gly Thr Glu Ile His Glu Ala Ser
    50                  55                  60                  
Ala Ile Leu Val His Leu Ser Arg Gly Gly Ala Glu Val Gln Ile Phe
65                  70                  75                  80  
Ala Pro Asp Val Pro Gln Met His Val Ile Asp His Thr Lys Gly Gln
                85                  90                  95      
Pro Ser Glu Gly Glu Ser Arg Asn Val Leu Thr Glu Ser Ala Arg Ile
            100                 105                 110         
Ala Arg Gly Lys Ile Thr Asp Leu Ala Asn Leu Ser Ala Ala Asn His
        115                 120                 125             
Asp Ala Ala Ile Phe Pro Gly Gly Phe Gly Ala Ala Lys Asn Leu Ser
    130                 135                 140                 
Thr Phe Ala Val Asp Gly Lys Asp Cys Lys Val Asn Lys Glu Val Glu
145                 150                 155                 160 
Arg Val Leu Lys Glu Phe His Gln Ala Gly Lys Pro Ile Gly Leu Cys
                165                 170                 175     
Cys Ile Ala Pro Val Leu Ala Ala Lys Val Leu Arg Gly Val Glu Val
            180                 185                 190         
Thr Val Gly His Glu Gln Glu Glu Gly Gly Lys Trp Pro Tyr Ala Gly
        195                 200                 205             
Thr Ala Glu Ala Ile Lys Ala Leu Gly Ala Lys His Cys Val Lys Glu
    210                 215                 220                 
Val Val Glu Ala His Val Asp Gln Lys Asn Lys Val Val Thr Thr Pro
225                 230                 235                 240 
Ala Phe Met Cys Glu Thr Ala Leu His Tyr Ile His Asp Gly Ile Gly
                245                 250                 255     
Ala Met Val Arg Lys Val Leu Glu Leu Thr Gly Lys
            260                 265             


<210> 2248
<211> 720
<212> PRT
<213> Homo sapiens

<400> 2248
Met Arg Ser Met Cys Asn Gln Gly Arg Gly Arg Glu Ser Ser Arg Gly
 1               5                  10                  15      
Gly Leu His Val Gln Gly Ser Cys Arg Gly Leu Ser Arg Ser Pro Gln
            20                  25                  30          
Gln Glu Thr Gly Phe Ala Lys Ala Pro Ala Gly Thr Asp Cys Phe Phe
        35                  40                  45              
His Cys Ser Pro Gly Ser Arg Gly Gln Gly Asp Arg Lys Glu Glu Val
    50                  55                  60                  
Thr Ser Glu Pro Gly Gly Thr Ser Ile Met Ser Arg Leu Gly Gly Met
65                  70                  75                  80  
Asn Ala Ala Val Arg Ala Val Thr Arg Met Gly Ile Tyr Val Gly Ala
                85                  90                  95      
Lys Val Phe Leu Ile Tyr Glu Gly Tyr Glu Gly Leu Val Glu Gly Gly
            100                 105                 110         
Glu Asn Ile Lys Gln Ala Asn Trp Leu Ser Val Ser Asn Ile Ile Gln
        115                 120                 125             
Leu Gly Gly Thr Ile Ile Gly Ser Ala Arg Cys Lys Ala Phe Thr Thr
    130                 135                 140                 
Arg Glu Gly Arg Arg Ala Ala Ala Tyr Asn Leu Val Gln His Gly Ile
145                 150                 155                 160 
Thr Asn Leu Cys Val Ile Gly Gly Asp Gly Ser Leu Thr Gly Ala Asn
                165                 170                 175     
Ile Phe Arg Ser Glu Trp Gly Ser Leu Leu Glu Glu Leu Val Ala Glu
            180                 185                 190         
Gly Lys Ile Ser Glu Thr Thr Ala Arg Thr Tyr Ser His Leu Asn Ile
        195                 200                 205             
Ala Gly Leu Val Gly Ser Ile Asp Asn Asp Phe Cys Gly Thr Asp Met
    210                 215                 220                 
Thr Ile Gly Thr Asp Ser Ala Leu His Arg Ile Met Glu Val Ile Asp
225                 230                 235                 240 
Ala Ile Thr Thr Thr Ala Gln Ser His Gln Arg Thr Phe Val Leu Glu
                245                 250                 255     
Val Met Gly Arg His Cys Gly Tyr Leu Ala Leu Val Ser Ala Leu Ala
            260                 265                 270         
Ser Gly Ala Asp Trp Leu Phe Ile Pro Glu Ala Pro Pro Glu Asp Gly
        275                 280                 285             
Trp Glu Asn Phe Met Cys Glu Arg Leu Gly Glu Thr Arg Ser Arg Gly
    290                 295                 300                 
Ser Arg Leu Asn Ile Ile Ile Ile Ala Glu Gly Ala Ile Asp Arg Asn
305                 310                 315                 320 
Gly Lys Pro Ile Ser Ser Ser Tyr Val Lys Asp Leu Val Val Gln Arg
                325                 330                 335     
Leu Gly Phe Asp Thr Arg Val Thr Val Leu Gly His Val Gln Arg Gly
            340                 345                 350         
Gly Thr Pro Ser Ala Phe Asp Arg Ile Leu Ser Ser Lys Met Gly Met
        355                 360                 365             
Glu Ala Val Met Ala Leu Leu Glu Ala Thr Pro Asp Thr Pro Ala Cys
    370                 375                 380                 
Val Val Thr Leu Ser Gly Asn Gln Ser Val Arg Leu Pro Leu Met Glu
385                 390                 395                 400 
Cys Val Gln Met Thr Lys Glu Val Gln Lys Ala Met Asp Asp Lys Arg
                405                 410                 415     
Phe Asp Glu Ala Thr Gln Leu Arg Gly Gly Ser Phe Glu Asn Asn Trp
            420                 425                 430         
Asn Ile Tyr Lys Leu Leu Ala His Gln Lys Pro Pro Lys Glu Lys Ser
        435                 440                 445             
Asn Phe Ser Leu Ala Ile Leu Asn Val Gly Ala Pro Ala Ala Gly Met
    450                 455                 460                 
Asn Ala Ala Val Arg Ser Ala Val Arg Thr Gly Ile Ser His Gly His
465                 470                 475                 480 
Thr Val Tyr Val Val His Asp Gly Phe Glu Gly Leu Ala Lys Gly Gln
                485                 490                 495     
Val Gln Glu Val Gly Trp His Asp Val Ala Gly Trp Leu Gly Arg Gly
            500                 505                 510         
Gly Ser Met Leu Gly Thr Lys Arg Thr Leu Pro Lys Gly Gln Leu Glu
        515                 520                 525             
Ser Ile Val Glu Asn Ile Arg Ile Tyr Gly Ile His Ala Leu Leu Val
    530                 535                 540                 
Val Gly Gly Phe Glu Ala Tyr Glu Gly Val Leu Gln Leu Val Glu Ala
545                 550                 555                 560 
Arg Gly Arg Tyr Glu Glu Leu Cys Ile Val Met Cys Val Ile Pro Ala
                565                 570                 575     
Thr Ile Ser Asn Asn Val Pro Gly Thr Asp Phe Ser Leu Gly Ser Asp
            580                 585                 590         
Thr Ala Val Asn Ala Ala Met Glu Ser Cys Asp Arg Ile Lys Gln Ser
        595                 600                 605             
Ala Ser Gly Thr Lys Arg Arg Val Phe Ile Val Glu Thr Met Gly Gly
    610                 615                 620                 
Tyr Cys Gly Tyr Leu Ala Thr Val Thr Gly Ile Ala Val Gly Ala Asp
625                 630                 635                 640 
Ala Ala Tyr Val Phe Glu Asp Pro Phe Asn Ile His Asp Leu Lys Val
                645                 650                 655     
Asn Val Glu His Met Thr Glu Lys Met Lys Thr Asp Ile Gln Arg Gly
            660                 665                 670         
Leu Val Leu Arg Asn Glu Lys Cys His Asp Tyr Tyr Thr Thr Glu Phe
        675                 680                 685             
Leu Tyr Asn Leu Tyr Ser Ser Glu Gly Lys Gly Val Phe Asp Cys Arg
    690                 695                 700                 
Thr Asn Val Leu Gly His Leu Gln Gln Gly Trp Arg Ser Asn Pro Leu
705                 710                 715                 720 


<210> 2249
<211> 1699
<212> PRT
<213> Homo sapiens

<400> 2249
Met Gln Glu Glu Glu Ile Lys Arg Leu Glu Glu Met Asn Ile Asn Ile
 1               5                  10                  15      
Arg Lys Lys Val Ala Gln Leu Gln Glu Glu Val Glu Lys Gln Lys Asn
            20                  25                  30          
Ile Val Lys Gly Leu Glu Gln Asp Lys Glu Val Leu Lys Lys Gln Gln
        35                  40                  45              
Met Ser Ser Leu Leu Leu Ala Ser Thr Leu Gln Ser Thr Leu Asp Ala
    50                  55                  60                  
Gly Arg Cys Pro Glu Pro Pro Ser Gly Ser Pro Pro Glu Gly Pro Glu
65                  70                  75                  80  
Ile Gln Leu Glu Val Thr Gln Arg Ala Leu Leu Arg Arg Glu Ser Glu
                85                  90                  95      
Val Leu Asp Leu Lys Glu Gln Leu Glu Lys Met Lys Gly Asp Leu Glu
            100                 105                 110         
Ser Lys Asn Glu Glu Ile Leu His Leu Asn Leu Lys Leu Asp Met Gln
        115                 120                 125             
Asn Ser Gln Thr Ala Val Ser Leu Arg Glu Leu Glu Glu Glu Asn Thr
    130                 135                 140                 
Ser Leu Lys Val Ile Tyr Thr Arg Ser Ser Glu Ile Glu Glu Leu Lys
145                 150                 155                 160 
Ala Thr Ile Glu Asn Leu Gln Glu Asn Gln Lys Arg Leu Gln Lys Glu
                165                 170                 175     
Lys Ala Glu Glu Ile Glu Gln Leu His Glu Val Ile Glu Lys Leu Gln
            180                 185                 190         
His Glu Leu Ser Leu Met Gly Pro Val Val His Glu Val Ser Asp Ser
        195                 200                 205             
Gln Ala Gly Ser Leu Gln Ser Glu Leu Leu Cys Ser Gln Ala Gly Gly
    210                 215                 220                 
Pro Arg Gly Gln Ala Leu Gln Gly Glu Leu Glu Ala Ala Leu Glu Ala
225                 230                 235                 240 
Lys Glu Ala Leu Ser Arg Leu Leu Ala Asp Gln Glu Arg Arg His Ser
                245                 250                 255     
Gln Ala Leu Glu Ala Leu Gln Gln Arg Leu Gln Gly Ala Glu Glu Ala
            260                 265                 270         
Ala Glu Leu Gln Leu Ala Glu Leu Glu Arg Asn Val Ala Leu Arg Glu
        275                 280                 285             
Ala Glu Val Glu Asp Met Ala Ser Arg Ile Gln Glu Phe Glu Ala Ala
    290                 295                 300                 
Leu Lys Ala Lys Glu Ala Thr Ile Ala Glu Arg Asn Leu Glu Ile Asp
305                 310                 315                 320 
Ala Leu Asn Gln Arg Lys Ala Ala His Ser Ala Glu Leu Glu Ala Val
                325                 330                 335     
Leu Leu Ala Leu Ala Arg Ile Arg Arg Ala Leu Glu Gln Gln Pro Leu
            340                 345                 350         
Ala Ala Gly Ala Ala Pro Pro Glu Leu Gln Trp Leu Arg Ala Gln Cys
        355                 360                 365             
Ala Arg Leu Ser Arg Gln Leu Gln Val Leu His Gln Arg Phe Leu Arg
    370                 375                 380                 
Cys Gln Val Glu Leu Asp Arg Arg Gln Ala Arg Arg Ala Thr Ala His
385                 390                 395                 400 
Thr Arg Val Pro Gly Ala His Pro Gln Pro Arg Met Asp Gly Gly Ala
                405                 410                 415     
Lys Ala Gln Val Thr Gly Asp Val Glu Ala Ser His Asp Ala Ala Leu
            420                 425                 430         
Glu Pro Val Val Pro Asp Pro Gln Gly Asp Leu Gln Pro Val Leu Val
        435                 440                 445             
Thr Leu Lys Asp Ala Pro Leu Cys Lys Gln Glu Gly Val Met Ser Val
    450                 455                 460                 
Leu Thr Val Cys Gln Arg Gln Leu Gln Ser Glu Leu Leu Leu Val Lys
465                 470                 475                 480 
Asn Glu Met Arg Leu Ser Leu Glu Asp Gly Gly Lys Gly Lys Glu Lys
                485                 490                 495     
Val Leu Glu Asp Cys Gln Leu Pro Lys Val Asp Leu Val Ala Gln Val
            500                 505                 510         
Lys Gln Leu Gln Glu Lys Leu Asn Arg Leu Leu Tyr Ser Met Thr Phe
        515                 520                 525             
Gln Asn Val Asp Ala Ala Asp Thr Lys Ser Leu Trp Pro Met Ala Ser
    530                 535                 540                 
Ala His Leu Leu Glu Ser Ser Trp Ser Asp Asp Ser Cys Asp Gly Glu
545                 550                 555                 560 
Glu Pro Asp Ile Ser Pro His Ile Asp Thr Cys Asp Ala Asn Thr Ala
                565                 570                 575     
Thr Gly Gly Val Thr Asp Val Ile Lys Asn Gln Ala Ile Asp Ala Cys
            580                 585                 590         
Asp Ala Asn Thr Thr Pro Gly Gly Val Thr Asp Val Ile Lys Asn Trp
        595                 600                 605             
Asp Ser Leu Ile Pro Asp Glu Met Pro Asp Ser Pro Ile Gln Glu Lys
    610                 615                 620                 
Ser Glu Cys Gln Asp Met Ser Leu Ser Ser Pro Thr Ser Val Leu Gly
625                 630                 635                 640 
Gly Ser Arg His Gln Ser His Thr Ala Glu Ala Gly Pro Arg Lys Ser
                645                 650                 655     
Pro Val Gly Met Leu Asp Leu Ser Ser Trp Ser Ser Pro Glu Val Leu
            660                 665                 670         
Arg Lys Asp Trp Thr Leu Glu Pro Trp Pro Ser Leu Pro Val Thr Pro
        675                 680                 685             
His Ser Gly Ala Leu Ser Leu Cys Ser Ala Asp Thr Ser Leu Gly Asp
    690                 695                 700                 
Arg Ala Asp Thr Ser Leu Pro Gln Thr Gln Gly Pro Gly Leu Leu Cys
705                 710                 715                 720 
Ser Pro Gly Val Ser Ala Ala Ala Leu Ala Leu Gln Trp Ala Glu Ser
                725                 730                 735     
Pro Pro Ala Asp Asp His His Val Gln Arg Thr Ala Val Glu Lys Asp
            740                 745                 750         
Val Glu Asp Phe Ile Thr Thr Ser Phe Asp Ser Gln Glu Thr Leu Ser
        755                 760                 765             
Ser Pro Pro Pro Gly Leu Glu Gly Lys Ala Asp Arg Ser Glu Lys Ser
    770                 775                 780                 
Asp Gly Ser Gly Phe Gly Ala Arg Leu Ser Pro Gly Ser Gly Gly Pro
785                 790                 795                 800 
Glu Ala Gln Thr Ala Gly Pro Val Thr Pro Ala Ser Ile Ser Gly Arg
                805                 810                 815     
Phe Gln Pro Leu Pro Glu Ala Met Lys Glu Lys Glu Val Arg Pro Lys
            820                 825                 830         
His Val Lys Ala Leu Leu Gln Met Val Arg Asp Glu Ser His Gln Ile
        835                 840                 845             
Leu Ala Leu Ser Glu Gly Leu Ala Pro Pro Ser Gly Glu Pro His Pro
    850                 855                 860                 
Pro Arg Lys Glu Asp Glu Ile Gln Asp Ile Ser Leu His Gly Gly Lys
865                 870                 875                 880 
Thr Gln Glu Val Pro Thr Ala Cys Pro Asp Trp Arg Gly Asp Leu Leu
                885                 890                 895     
Gln Val Val Gln Glu Ala Phe Glu Lys Glu Gln Glu Met Gln Gly Val
            900                 905                 910         
Glu Leu Gln Pro Arg Leu Ser Gly Ser Asp Leu Gly Gly His Ser Ser
        915                 920                 925             
Leu Leu Glu Arg Leu Glu Lys Ile Ile Arg Glu Gln Gly Asp Leu Gln
    930                 935                 940                 
Glu Lys Ser Leu Glu His Leu Arg Leu Pro Asp Arg Ser Ser Leu Leu
945                 950                 955                 960 
Ser Glu Ile Gln Ala Leu Arg Ala Gln Leu Arg Met Thr His Leu Gln
                965                 970                 975     
Asn Gln Glu Lys Leu Gln His Leu Arg Thr Ala Leu Thr Ser Ala Glu
            980                 985                 990         
Ala Arg Gly Ser Gln Gln Glu His Gln Leu Arg Arg Gln Val Glu Leu
        995                 1000                1005            
Leu Ala Tyr Lys Val Glu Gln Glu Lys Cys Ile Ala Gly Asp Leu Gln
    1010                1015                1020                
Lys Thr Leu Ser Glu Glu Gln Glu Lys Ala Asn Ser Val Gln Lys Leu
1025                1030                1035                1040
Leu Ala Ala Glu Gln Thr Val Val Arg Asp Leu Lys Ser Asp Leu Cys
                1045                1050                1055    
Glu Ser Arg Gln Lys Ser Glu Gln Leu Ser Arg Ser Leu Cys Glu Val
            1060                1065                1070        
Gln Gln Glu Val Leu Gln Leu Arg Ser Met Leu Ser Ser Lys Glu Asn
        1075                1080                1085            
Glu Leu Lys Ala Ala Leu Gln Glu Leu Glu Ser Glu Gln Gly Lys Gly
    1090                1095                1100                
Arg Ala Leu Gln Ser Gln Leu Glu Glu Glu Gln Leu Arg His Leu Gln
1105                1110                1115                1120
Arg Glu Ser Gln Ser Ala Lys Ala Leu Glu Glu Leu Arg Ala Ser Leu
                1125                1130                1135    
Glu Thr Gln Arg Ala Gln Ser Ser Arg Leu Cys Val Ala Leu Lys His
            1140                1145                1150        
Glu Gln Thr Ala Lys Asp Asn Leu Gln Lys Glu Leu Arg Ile Glu His
        1155                1160                1165            
Ser Arg Cys Glu Ala Leu Leu Ala Gln Glu Arg Ser Gln Leu Ser Glu
    1170                1175                1180                
Leu Gln Lys Asp Leu Ala Ala Glu Lys Ser Arg Thr Leu Glu Leu Ser
1185                1190                1195                1200
Glu Ala Leu Arg His Glu Arg Leu Leu Thr Glu Gln Leu Ser Gln Arg
                1205                1210                1215    
Thr Gln Glu Ala Cys Val His Gln Asp Thr Gln Ala His His Ala Leu
            1220                1225                1230        
Leu Gln Lys Leu Lys Glu Glu Lys Ser Arg Val Val Asp Leu Gln Ala
        1235                1240                1245            
Met Leu Glu Lys Val Gln Gln Gln Ala Leu His Ser Gln Gln Gln Leu
    1250                1255                1260                
Glu Ala Glu Ala Gln Lys His Cys Glu Ala Leu Arg Arg Glu Lys Glu
1265                1270                1275                1280
Arg Glu Leu Glu Leu Gln Arg Gln Arg Asp Leu His Lys Ile Lys Gln
                1285                1290                1295    
Leu Gln Gln Thr Val Arg Asp Leu Glu Ser Lys Asp Glu Val Pro Gly
            1300                1305                1310        
Ser Arg Leu His Leu Gly Ser Ala Arg Arg Ala Ala Gly Ser Asp Ala
        1315                1320                1325            
Asp His Leu Arg Glu Gln Gln Arg Glu Leu Glu Ala Met Arg Gln Arg
    1330                1335                1340                
Leu Leu Ser Ala Ala Arg Leu Leu Thr Ser Phe Thr Ser Gln Ala Val
1345                1350                1355                1360
Asp Arg Thr Val Asn Asp Trp Thr Ser Ser Asn Glu Lys Ala Val Met
                1365                1370                1375    
Ser Leu Leu His Thr Leu Glu Glu Leu Lys Ser Asp Leu Ser Arg Pro
            1380                1385                1390        
Thr Ser Ser Gln Lys Lys Met Ala Ala Glu Leu Gln Phe Gln Phe Val
        1395                1400                1405            
Asp Val Leu Leu Lys Asp Asn Val Ser Leu Thr Lys Ala Leu Ser Thr
    1410                1415                1420                
Val Thr Gln Glu Lys Leu Glu Leu Ser Arg Ala Val Ser Lys Leu Glu
1425                1430                1435                1440
Lys Leu Leu Lys His His Leu Gln Lys Gly Cys Ser Pro Ser Arg Ser
                1445                1450                1455    
Glu Arg Ser Ala Trp Lys Pro Asp Glu Thr Ala Pro Gln Ser Ser Leu
            1460                1465                1470        
Arg Arg Pro Asp Pro Gly Arg Leu Pro Pro Ala Ala Ser Glu Glu Ala
        1475                1480                1485            
His Thr Ser Asn Val Lys Met Glu Lys Leu Tyr Leu His Tyr Leu Arg
    1490                1495                1500                
Ala Glu Ser Phe Arg Lys Ala Leu Ile Tyr Gln Lys Lys Tyr Leu Leu
1505                1510                1515                1520
Leu Leu Ile Gly Gly Phe Gln Asp Ser Glu Gln Glu Thr Leu Ser Met
                1525                1530                1535    
Ile Ala His Leu Gly Val Phe Pro Ser Lys Ala Glu Arg Lys Ile Thr
            1540                1545                1550        
Ser Arg Pro Phe Thr Arg Phe Arg Thr Ala Val Arg Val Val Ile Ala
        1555                1560                1565            
Ile Leu Arg Leu Arg Phe Leu Val Lys Lys Trp Gln Glu Val Asp Arg
    1570                1575                1580                
Lys Gly Ala Leu Ala Gln Gly Lys Ala Pro Arg Pro Gly Pro Arg Ala
1585                1590                1595                1600
Arg Gln Pro Gln Ser Pro Pro Arg Thr Arg Glu Ser Pro Pro Thr Arg
                1605                1610                1615    
Asp Val Pro Ser Gly His Thr Arg Asp Pro Ala Arg Gly Arg Arg Leu
            1620                1625                1630        
Ala Ala Ala Ala Ser Pro His Ser Gly Gly Arg Ala Thr Pro Ser Pro
        1635                1640                1645            
Asn Ser Arg Leu Glu Arg Ser Leu Thr Ala Ser Gln Asp Pro Glu His
    1650                1655                1660                
Ser Leu Thr Glu Tyr Ile His His Leu Glu Val Ile Gln Gln Arg Leu
1665                1670                1675                1680
Gly Gly Val Leu Pro Asp Ser Thr Ser Lys Lys Ser Cys His Pro Met
                1685                1690                1695    
Ile Lys Gln
            


<210> 2250
<211> 3141
<212> PRT
<213> Homo sapiens

<400> 2250
Met Ala Thr Leu Glu Lys Leu Met Lys Ala Phe Glu Ser Leu Lys Ser
 1               5                  10                  15      
Phe Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
            20                  25                  30          
Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro
        35                  40                  45              
Gln Leu Pro Gln Pro Pro Pro Gln Ala Gln Pro Leu Leu Pro Gln Pro
    50                  55                  60                  
Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro Ala Val Ala
65                  70                  75                  80  
Glu Glu Pro Leu His Arg Pro Lys Lys Glu Leu Ser Ala Thr Lys Lys
                85                  90                  95      
Asp Arg Val Asn His Cys Leu Thr Ile Cys Glu Asn Ile Val Ala Gln
            100                 105                 110         
Ser Val Arg Asn Ser Pro Glu Phe Gln Lys Leu Leu Gly Ile Ala Met
        115                 120                 125             
Glu Leu Phe Leu Leu Cys Ser Asp Asp Ala Glu Ser Asp Val Arg Met
    130                 135                 140                 
Val Ala Asp Glu Cys Leu Asn Lys Val Ile Lys Ala Leu Met Asp Ser
145                 150                 155                 160 
Asn Leu Pro Arg Leu Gln Leu Glu Leu Tyr Lys Glu Ile Lys Lys Asn
                165                 170                 175     
Gly Ala Pro Arg Ser Leu Arg Ala Ala Leu Trp Arg Phe Ala Glu Leu
            180                 185                 190         
Ala His Leu Val Arg Pro Gln Lys Cys Arg Pro Tyr Leu Val Asn Leu
        195                 200                 205             
Leu Pro Cys Leu Thr Arg Thr Ser Lys Arg Pro Glu Glu Ser Val Gln
    210                 215                 220                 
Glu Thr Leu Ala Ala Ala Val Pro Lys Ile Met Ala Ser Phe Gly Asn
225                 230                 235                 240 
Phe Ala Asn Asp Asn Glu Ile Lys Val Leu Leu Lys Ala Phe Ile Ala
                245                 250                 255     
Asn Leu Lys Ser Ser Ser Pro Thr Ile Arg Arg Thr Ala Ala Gly Ser
            260                 265                 270         
Ala Val Ser Ile Cys Gln His Ser Arg Arg Thr Gln Tyr Phe Tyr Ser
        275                 280                 285             
Trp Leu Leu Asn Val Leu Leu Gly Leu Leu Val Pro Val Glu Asp Glu
    290                 295                 300                 
His Ser Thr Leu Leu Ile Leu Gly Val Leu Leu Thr Leu Arg Tyr Leu
305                 310                 315                 320 
Val Pro Leu Leu Gln Gln Gln Val Lys Asp Thr Ser Leu Lys Gly Ser
                325                 330                 335     
Phe Gly Val Thr Arg Lys Glu Met Glu Val Ser Pro Ser Ala Glu Gln
            340                 345                 350         
Leu Val Gln Val Tyr Glu Leu Thr Leu His His Thr Gln His Gln Asp
        355                 360                 365             
His Asn Val Val Thr Gly Ala Leu Glu Leu Leu Gln Gln Leu Phe Arg
    370                 375                 380                 
Thr Pro Pro Pro Glu Leu Leu Gln Thr Leu Thr Ala Val Gly Gly Ile
385                 390                 395                 400 
Gly Gln Leu Thr Ala Ala Lys Glu Glu Ser Gly Gly Arg Ser Arg Ser
                405                 410                 415     
Gly Ser Ile Val Glu Leu Ile Ala Gly Gly Gly Ser Ser Cys Ser Pro
            420                 425                 430         
Val Leu Ser Arg Lys Gln Lys Gly Lys Val Leu Leu Gly Glu Glu Glu
        435                 440                 445             
Ala Leu Glu Asp Asp Ser Glu Ser Arg Ser Asp Val Ser Ser Ser Ala
    450                 455                 460                 
Leu Thr Ala Ser Val Lys Asp Glu Ile Ser Gly Glu Leu Ala Ala Ser
465                 470                 475                 480 
Ser Gly Val Ser Thr Pro Gly Ser Ala Gly His Asp Ile Ile Thr Glu
                485                 490                 495     
Gln Pro Arg Ser Gln His Thr Leu Gln Ala Asp Ser Val Asp Leu Ala
            500                 505                 510         
Ser Cys Asp Leu Thr Ser Ser Ala Thr Asp Gly Asp Glu Glu Asp Ile
        515                 520                 525             
Leu Ser His Ser Ser Ser Gln Val Ser Ala Val Pro Ser Asp Pro Ala
    530                 535                 540                 
Met Asp Leu Asn Asp Gly Thr Gln Ala Ser Ser Pro Ile Ser Asp Ser
545                 550                 555                 560 
Ser Gln Thr Thr Thr Glu Gly Pro Asp Ser Ala Val Thr Pro Ser Asp
                565                 570                 575     
Ser Ser Glu Ile Val Leu Asp Gly Thr Asp Asn Gln Tyr Leu Gly Leu
            580                 585                 590         
Gln Ile Gly Gln Pro Gln Asp Glu Asp Glu Glu Ala Thr Gly Ile Leu
        595                 600                 605             
Pro Asp Glu Ala Ser Glu Ala Phe Arg Asn Ser Ser Met Ala Leu Gln
    610                 615                 620                 
Gln Ala His Leu Leu Lys Asn Met Ser His Cys Arg Gln Pro Ser Asp
625                 630                 635                 640 
Ser Ser Val Asp Lys Phe Val Leu Arg Asp Glu Ala Thr Glu Pro Gly
                645                 650                 655     
Asp Gln Glu Asn Lys Pro Cys Arg Ile Lys Gly Asp Ile Gly Gln Ser
            660                 665                 670         
Thr Asp Asp Asp Ser Ala Pro Leu Val His Cys Val Arg Leu Leu Ser
        675                 680                 685             
Ala Ser Phe Leu Leu Thr Gly Gly Lys Asn Val Leu Val Pro Asp Arg
    690                 695                 700                 
Asp Val Arg Val Ser Val Lys Ala Leu Ala Leu Ser Cys Val Gly Ala
705                 710                 715                 720 
Ala Val Ala Leu His Pro Glu Ser Phe Phe Ser Lys Leu Tyr Lys Val
                725                 730                 735     
Pro Leu Asp Thr Thr Glu Tyr Pro Glu Glu Gln Tyr Val Ser Asp Ile
            740                 745                 750         
Leu Asn Tyr Ile Asp His Gly Asp Pro Gln Val Arg Gly Ala Thr Ala
        755                 760                 765             
Ile Leu Cys Gly Thr Leu Ile Cys Ser Ile Leu Ser Arg Ser Arg Phe
    770                 775                 780                 
His Val Gly Asp Trp Met Gly Thr Ile Arg Thr Leu Thr Gly Asn Thr
785                 790                 795                 800 
Phe Ser Leu Ala Asp Cys Ile Pro Leu Leu Arg Lys Thr Leu Lys Asp
                805                 810                 815     
Glu Ser Ser Val Thr Cys Lys Leu Ala Cys Thr Ala Val Arg Asn Cys
            820                 825                 830         
Val Met Ser Leu Cys Ser Ser Ser Tyr Ser Glu Leu Gly Leu Gln Leu
        835                 840                 845             
Ile Ile Asp Val Leu Thr Leu Arg Asn Ser Ser Tyr Trp Leu Val Arg
    850                 855                 860                 
Thr Glu Leu Leu Glu Thr Leu Ala Glu Ile Asp Phe Arg Leu Val Ser
865                 870                 875                 880 
Phe Leu Glu Ala Lys Ala Glu Asn Leu His Arg Gly Ala His His Tyr
                885                 890                 895     
Thr Gly Leu Leu Lys Leu Gln Glu Arg Val Leu Asn Asn Val Val Ile
            900                 905                 910         
His Leu Leu Gly Asp Glu Asp Pro Arg Val Arg His Val Ala Ala Ala
        915                 920                 925             
Ser Leu Ile Arg Leu Val Pro Lys Leu Phe Tyr Lys Cys Asp Gln Gly
    930                 935                 940                 
Gln Ala Asp Pro Val Val Ala Val Ala Arg Asp Gln Ser Ser Val Tyr
945                 950                 955                 960 
Leu Lys Leu Leu Met His Glu Thr Gln Pro Pro Ser His Phe Ser Val
                965                 970                 975     
Ser Thr Ile Thr Arg Ile Tyr Arg Gly Tyr Asn Leu Leu Pro Ser Ile
            980                 985                 990         
Thr Asp Val Thr Met Glu Asn Asn Leu Ser Arg Val Ile Ala Ala Val
        995                 1000                1005            
Ser His Glu Leu Ile Thr Ser Thr Thr Arg Ala Leu Thr Phe Gly Cys
    1010                1015                1020                
Cys Glu Ala Leu Cys Leu Leu Ser Thr Ala Phe Pro Val Cys Ile Trp
1025                1030                1035                1040
Ser Leu Gly Trp His Cys Gly Val Pro Pro Leu Ser Ala Ser Asp Glu
                1045                1050                1055    
Ser Arg Lys Ser Cys Thr Val Gly Met Ala Thr Met Ile Leu Thr Leu
            1060                1065                1070        
Leu Ser Ser Ala Trp Phe Pro Leu Asp Leu Ser Ala His Gln Asp Ala
        1075                1080                1085            
Leu Ile Leu Ala Gly Asn Leu Leu Ala Ala Ser Ala Pro Lys Ser Leu
    1090                1095                1100                
Arg Ser Ser Trp Ala Ser Glu Glu Glu Ala Asn Pro Ala Ala Thr Lys
1105                1110                1115                1120
Gln Glu Glu Val Trp Pro Ala Leu Gly Asp Arg Ala Leu Val Pro Met
                1125                1130                1135    
Val Glu Gln Leu Phe Ser His Leu Leu Lys Val Ile Asn Ile Cys Ala
            1140                1145                1150        
His Val Leu Asp Asp Val Ala Pro Gly Pro Ala Ile Lys Ala Ala Leu
        1155                1160                1165            
Pro Ser Leu Thr Asn Pro Pro Ser Leu Ser Pro Ile Arg Arg Lys Gly
    1170                1175                1180                
Lys Glu Lys Glu Pro Gly Glu Gln Ala Ser Val Pro Leu Ser Pro Lys
1185                1190                1195                1200
Lys Gly Ser Glu Ala Ser Ala Ala Ser Arg Gln Ser Asp Thr Ser Gly
                1205                1210                1215    
Pro Val Thr Thr Ser Lys Ser Ser Ser Leu Gly Ser Phe Tyr His Leu
            1220                1225                1230        
Pro Ser Tyr Leu Lys Leu His Asp Val Leu Lys Ala Thr His Ala Asn
        1235                1240                1245            
Tyr Lys Val Thr Leu Asp Leu Gln Asn Ser Thr Glu Lys Phe Gly Gly
    1250                1255                1260                
Phe Leu Arg Ser Ala Leu Asp Val Leu Ser Gln Ile Leu Glu Leu Ala
1265                1270                1275                1280
Thr Leu Gln Asp Ile Gly Lys Cys Val Glu Glu Ile Leu Gly Tyr Leu
                1285                1290                1295    
Lys Ser Cys Phe Ser Arg Glu Pro Met Met Ala Thr Val Cys Val Gln
            1300                1305                1310        
Gln Leu Leu Lys Thr Leu Phe Gly Thr Asn Leu Ala Ser Gln Phe Asp
        1315                1320                1325            
Gly Leu Ser Ser Asn Pro Ser Lys Ser Gln Gly Arg Ala Gln Arg Leu
    1330                1335                1340                
Gly Ser Ser Ser Val Arg Pro Gly Leu Tyr His Tyr Cys Phe Met Ala
1345                1350                1355                1360
Pro Tyr Thr His Phe Thr Gln Ala Leu Ala Asp Ala Ser Leu Arg Asn
                1365                1370                1375    
Met Val Gln Ala Glu Gln Glu Asn Asp Thr Ser Gly Trp Phe Asp Val
            1380                1385                1390        
Leu Gln Lys Val Ser Thr Gln Leu Lys Thr Asn Leu Thr Ser Val Thr
        1395                1400                1405            
Lys Asn Arg Ala Asp Lys Asn Ala Ile His Asn His Ile Arg Leu Phe
    1410                1415                1420                
Glu Pro Leu Val Ile Lys Ala Leu Lys Gln Tyr Thr Thr Thr Thr Cys
1425                1430                1435                1440
Val Gln Leu Gln Lys Gln Val Leu Asp Leu Leu Ala Gln Leu Val Gln
                1445                1450                1455    
Leu Arg Val Asn Tyr Cys Leu Leu Asp Ser Asp Gln Val Phe Ile Gly
            1460                1465                1470        
Phe Val Leu Lys Gln Phe Glu Tyr Ile Glu Val Gly Gln Phe Arg Glu
        1475                1480                1485            
Ser Glu Ala Ile Ile Pro Asn Ile Phe Phe Phe Leu Val Leu Leu Ser
    1490                1495                1500                
Tyr Glu Arg Tyr His Ser Lys Gln Ile Ile Gly Ile Pro Lys Ile Ile
1505                1510                1515                1520
Gln Leu Cys Asp Gly Ile Met Ala Ser Gly Arg Lys Ala Val Thr His
                1525                1530                1535    
Ala Ile Pro Ala Leu Gln Pro Ile Val His Asp Leu Phe Val Leu Arg
            1540                1545                1550        
Gly Thr Asn Lys Ala Asp Ala Gly Lys Glu Leu Glu Thr Gln Lys Glu
        1555                1560                1565            
Val Val Val Ser Met Leu Leu Arg Leu Ile Gln Tyr His Gln Val Leu
    1570                1575                1580                
Glu Met Phe Ile Leu Val Leu Gln Gln Cys His Lys Glu Asn Glu Asp
1585                1590                1595                1600
Lys Trp Lys Arg Leu Ser Arg Gln Ile Ala Asp Ile Ile Leu Pro Met
                1605                1610                1615    
Leu Ala Lys Gln Gln Met His Ile Asp Ser His Glu Ala Leu Gly Val
            1620                1625                1630        
Leu Asn Thr Leu Phe Glu Ile Leu Ala Pro Ser Ser Leu Arg Pro Val
        1635                1640                1645            
Asp Met Leu Leu Arg Ser Met Phe Val Thr Pro Asn Thr Met Ala Ser
    1650                1655                1660                
Val Ser Thr Val Gln Leu Trp Ile Ser Gly Ile Leu Ala Ile Leu Arg
1665                1670                1675                1680
Val Leu Ile Ser Gln Ser Thr Glu Asp Ile Val Leu Ser Arg Ile Gln
                1685                1690                1695    
Glu Leu Ser Phe Ser Pro Tyr Leu Ile Ser Cys Thr Val Ile Asn Arg
            1700                1705                1710        
Leu Arg Asp Gly Asp Ser Thr Ser Thr Leu Glu Glu His Ser Glu Gly
        1715                1720                1725            
Lys Gln Ile Lys Asn Leu Pro Glu Glu Thr Phe Ser Arg Phe Leu Leu
    1730                1735                1740                
Gln Leu Val Gly Ile Leu Leu Glu Asp Ile Val Thr Lys Gln Leu Lys
1745                1750                1755                1760
Val Glu Met Ser Glu Gln Gln His Thr Phe Tyr Cys Gln Glu Leu Gly
                1765                1770                1775    
Thr Leu Leu Met Cys Leu Ile His Ile Phe Lys Ser Gly Met Phe Arg
            1780                1785                1790        
Arg Ile Thr Ala Ala Ala Thr Arg Leu Phe Arg Ser Asp Gly Cys Gly
        1795                1800                1805            
Gly Ser Phe Tyr Thr Leu Asp Ser Leu Asn Leu Arg Ala Arg Ser Met
    1810                1815                1820                
Ile Thr Thr His Pro Ala Leu Val Leu Leu Trp Cys Gln Ile Leu Leu
1825                1830                1835                1840
Leu Val Asn His Thr Asp Tyr Arg Trp Trp Ala Glu Val Gln Gln Thr
                1845                1850                1855    
Pro Lys Arg His Ser Leu Ser Ser Thr Lys Leu Leu Ser Pro Gln Met
            1860                1865                1870        
Ser Gly Glu Glu Glu Asp Ser Asp Leu Ala Ala Lys Leu Gly Met Cys
        1875                1880                1885            
Asn Arg Glu Ile Val Arg Arg Gly Ala Leu Ile Leu Phe Cys Asp Tyr
    1890                1895                1900                
Val Cys Gln Asn Leu His Asp Ser Glu His Leu Thr Trp Leu Ile Val
1905                1910                1915                1920
Asn His Ile Gln Asp Leu Ile Ser Leu Ser His Glu Pro Pro Val Gln
                1925                1930                1935    
Asp Phe Ile Ser Ala Val His Arg Asn Ser Ala Ala Ser Gly Leu Phe
            1940                1945                1950        
Ile Gln Ala Ile Gln Ser Arg Cys Glu Asn Leu Ser Thr Pro Thr Met
        1955                1960                1965            
Leu Lys Lys Thr Leu Gln Cys Leu Glu Gly Ile His Leu Ser Gln Ser
    1970                1975                1980                
Gly Ala Val Leu Thr Leu Tyr Val Asp Arg Leu Leu Cys Thr Pro Phe
1985                1990                1995                2000
Arg Val Leu Ala Arg Met Val Asp Ile Leu Ala Cys Arg Arg Val Glu
                2005                2010                2015    
Met Leu Leu Ala Ala Asn Leu Gln Ser Ser Met Ala Gln Leu Pro Met
            2020                2025                2030        
Glu Glu Leu Asn Arg Ile Gln Glu Tyr Leu Gln Ser Ser Gly Leu Ala
        2035                2040                2045            
Gln Arg His Gln Arg Leu Tyr Ser Leu Leu Asp Arg Phe Arg Leu Ser
    2050                2055                2060                
Thr Met Gln Asp Ser Leu Ser Pro Ser Pro Pro Val Ser Ser His Pro
2065                2070                2075                2080
Leu Asp Gly Asp Gly His Val Ser Leu Glu Thr Val Ser Pro Asp Lys
                2085                2090                2095    
Asp Trp Tyr Val His Leu Val Lys Ser Gln Cys Trp Thr Arg Ser Asp
            2100                2105                2110        
Ser Ala Leu Leu Glu Gly Ala Glu Leu Val Asn Arg Ile Pro Ala Glu
        2115                2120                2125            
Asp Met Asn Ala Phe Met Met Asn Ser Glu Phe Asn Leu Ser Leu Leu
    2130                2135                2140                
Ala Pro Cys Leu Ser Leu Gly Met Ser Glu Ile Ser Gly Gly Gln Lys
2145                2150                2155                2160
Ser Ala Leu Phe Glu Ala Ala Arg Glu Val Thr Leu Ala Arg Val Ser
                2165                2170                2175    
Gly Thr Val Gln Gln Leu Pro Ala Val His His Val Phe Gln Pro Glu
            2180                2185                2190        
Leu Pro Ala Glu Pro Ala Ala Tyr Trp Ser Lys Leu Asn Asp Leu Phe
        2195                2200                2205            
Gly Asp Ala Ala Leu Tyr Gln Ser Leu Pro Thr Leu Ala Arg Ala Leu
    2210                2215                2220                
Ala Gln Tyr Leu Val Val Val Ser Lys Leu Pro Ser His Leu His Leu
2225                2230                2235                2240
Pro Pro Glu Lys Glu Lys Asp Ile Val Lys Phe Val Val Ala Thr Leu
                2245                2250                2255    
Glu Ala Leu Ser Trp His Leu Ile His Glu Gln Ile Pro Leu Ser Leu
            2260                2265                2270        
Asp Leu Gln Ala Gly Leu Asp Cys Cys Cys Leu Ala Leu Gln Leu Pro
        2275                2280                2285            
Gly Leu Trp Ser Val Val Ser Ser Thr Glu Phe Val Thr His Ala Cys
    2290                2295                2300                
Ser Leu Ile Tyr Cys Val His Phe Ile Leu Glu Ala Val Ala Val Gln
2305                2310                2315                2320
Pro Gly Glu Gln Leu Leu Ser Pro Glu Arg Arg Thr Asn Thr Pro Lys
                2325                2330                2335    
Ala Ile Ser Glu Glu Glu Glu Glu Val Asp Pro Asn Thr Gln Asn Pro
            2340                2345                2350        
Lys Tyr Ile Thr Ala Ala Cys Glu Met Val Ala Glu Met Val Glu Ser
        2355                2360                2365            
Leu Gln Ser Val Leu Ala Leu Gly His Lys Arg Asn Ser Gly Val Pro
    2370                2375                2380                
Ala Phe Leu Thr Pro Leu Leu Arg Asn Ile Ile Ile Ser Leu Ala Arg
2385                2390                2395                2400
Leu Pro Leu Val Asn Ser Tyr Thr Arg Val Pro Pro Leu Val Trp Lys
                2405                2410                2415    
Leu Gly Trp Ser Pro Lys Pro Gly Gly Asp Phe Gly Thr Ala Phe Pro
            2420                2425                2430        
Glu Ile Pro Val Glu Phe Leu Gln Glu Lys Glu Val Phe Lys Glu Phe
        2435                2440                2445            
Ile Tyr Arg Ile Asn Thr Leu Gly Trp Thr Ser Arg Thr Gln Phe Glu
    2450                2455                2460                
Glu Thr Trp Ala Thr Leu Leu Gly Val Leu Val Thr Gln Pro Leu Val
2465                2470                2475                2480
Met Glu Gln Glu Glu Ser Pro Pro Glu Glu Asp Thr Glu Arg Thr Gln
                2485                2490                2495    
Ile Asn Val Leu Ala Val Gln Ala Ile Thr Ser Leu Val Leu Ser Ala
            2500                2505                2510        
Met Thr Val Pro Val Ala Gly Asn Pro Ala Val Ser Cys Leu Glu Gln
        2515                2520                2525            
Gln Pro Arg Asn Lys Pro Leu Lys Ala Leu Asp Thr Arg Phe Gly Arg
    2530                2535                2540                
Lys Leu Ser Ile Ile Arg Gly Ile Val Glu Gln Glu Ile Gln Ala Met
2545                2550                2555                2560
Val Ser Lys Arg Glu Asn Ile Ala Thr His His Leu Tyr Gln Ala Trp
                2565                2570                2575    
Asp Pro Val Pro Ser Leu Ser Pro Ala Thr Thr Gly Ala Leu Ile Ser
            2580                2585                2590        
His Glu Lys Leu Leu Leu Gln Ile Asn Pro Glu Arg Glu Leu Gly Ser
        2595                2600                2605            
Met Ser Tyr Lys Leu Gly Gln Val Ser Ile His Ser Val Trp Leu Gly
    2610                2615                2620                
Asn Ser Ile Thr Pro Leu Arg Glu Glu Glu Trp Asp Glu Glu Glu Glu
2625                2630                2635                2640
Glu Glu Ala Asp Ala Pro Ala Pro Ser Ser Pro Pro Thr Ser Pro Val
                2645                2650                2655    
Asn Ser Arg Lys His Arg Ala Gly Val Asp Ile His Ser Cys Ser Gln
            2660                2665                2670        
Phe Leu Leu Glu Leu Tyr Ser Arg Trp Ile Leu Pro Ser Ser Ser Ala
        2675                2680                2685            
Arg Arg Thr Pro Ala Ile Leu Ile Ser Glu Val Val Arg Ser Leu Leu
    2690                2695                2700                
Val Val Ser Asp Leu Phe Thr Glu Arg Asn Gln Phe Glu Leu Met Tyr
2705                2710                2715                2720
Val Thr Leu Thr Glu Leu Arg Arg Val His Pro Ser Glu Asp Glu Ile
                2725                2730                2735    
Leu Ala Gln Tyr Leu Val Pro Ala Thr Cys Lys Ala Ala Ala Val Leu
            2740                2745                2750        
Gly Met Asp Lys Ala Val Ala Glu Pro Val Ser Arg Leu Leu Glu Ser
        2755                2760                2765            
Thr Leu Arg Ser Ser His Leu Pro Ser Arg Val Gly Ala Leu His Gly
    2770                2775                2780                
Val Leu Tyr Val Leu Glu Cys Asp Leu Leu Asp Asp Thr Ala Lys Gln
2785                2790                2795                2800
Leu Ile Pro Val Ile Ser Asp Tyr Leu Leu Ser Asn Leu Lys Gly Ile
                2805                2810                2815    
Ala His Cys Val Asn Ile His Ser Gln Gln His Val Leu Val Met Cys
            2820                2825                2830        
Ala Thr Ala Phe Tyr Leu Ile Glu Asn Tyr Pro Leu Asp Val Gly Pro
        2835                2840                2845            
Glu Phe Ser Ala Ser Ile Ile Gln Met Cys Gly Val Met Leu Ser Gly
    2850                2855                2860                
Ser Glu Glu Ser Thr Pro Ser Ile Ile Tyr His Cys Ala Leu Arg Gly
2865                2870                2875                2880
Leu Glu Arg Leu Leu Leu Ser Glu Gln Leu Ser Arg Leu Asp Ala Glu
                2885                2890                2895    
Ser Leu Val Lys Leu Ser Val Asp Arg Val Asn Val His Ser Pro His
            2900                2905                2910        
Arg Ala Met Ala Ala Leu Gly Leu Met Leu Thr Cys Met Tyr Thr Gly
        2915                2920                2925            
Lys Glu Lys Val Ser Pro Gly Arg Thr Ser Asp Pro Asn Pro Ala Ala
    2930                2935                2940                
Pro Asp Ser Glu Ser Val Ile Val Ala Met Glu Arg Val Ser Val Leu
2945                2950                2955                2960
Phe Asp Arg Ile Arg Lys Gly Phe Pro Cys Glu Ala Arg Val Val Ala
                2965                2970                2975    
Arg Ile Leu Pro Gln Phe Leu Asp Asp Phe Phe Pro Pro Gln Asp Ile
            2980                2985                2990        
Met Asn Lys Val Ile Gly Glu Phe Leu Ser Asn Gln Gln Pro Tyr Pro
        2995                3000                3005            
Gln Phe Met Ala Thr Val Val Tyr Lys Val Phe Gln Thr Leu His Ser
    3010                3015                3020                
Thr Gly Gln Ser Ser Met Val Arg Asp Trp Val Met Leu Ser Leu Ser
3025                3030                3035                3040
Asn Phe Thr Gln Arg Ala Pro Val Ala Met Ala Thr Trp Ser Leu Ser
                3045                3050                3055    
Cys Phe Phe Val Ser Ala Ser Thr Ser Pro Trp Val Ala Ala Ile Leu
            3060                3065                3070        
Pro His Val Ile Ser Arg Met Gly Lys Leu Glu Gln Val Asp Val Asn
        3075                3080                3085            
Leu Phe Cys Leu Val Ala Thr Asp Phe Tyr Arg His Gln Ile Glu Glu
    3090                3095                3100                
Glu Leu Asp Arg Arg Ala Phe Gln Ser Val Leu Glu Val Val Ala Ala
3105                3110                3115                3120
Pro Gly Ser Pro Tyr His Arg Leu Leu Thr Cys Leu Arg Asn Val His
                3125                3130                3135    
Lys Val Thr Thr Cys
            3140    


<210> 2251
<211> 244
<212> PRT
<213> Homo sapiens

<400> 2251
Met Ala Ala Ala Ala Ala Ala Gly Glu Ala Arg Arg Val Leu Val Tyr
 1               5                  10                  15      
Gly Gly Arg Gly Ala Leu Gly Ser Arg Cys Val Gln Ala Phe Arg Ala
            20                  25                  30          
Arg Asn Trp Trp Val Ala Ser Val Asp Val Val Glu Asn Glu Glu Ala
        35                  40                  45              
Ser Ala Ser Ile Ile Val Lys Met Thr Asp Ser Phe Thr Glu Gln Ala
    50                  55                  60                  
Asp Gln Val Thr Ala Glu Val Gly Lys Leu Leu Gly Glu Glu Lys Val
65                  70                  75                  80  
Asp Ala Ile Leu Cys Val Ala Gly Gly Trp Ala Gly Gly Asn Ala Lys
                85                  90                  95      
Ser Lys Ser Leu Phe Lys Asn Cys Asp Leu Met Trp Lys Gln Ser Ile
            100                 105                 110         
Trp Thr Ser Thr Ile Ser Ser His Leu Ala Thr Lys His Leu Lys Glu
        115                 120                 125             
Gly Gly Leu Leu Thr Leu Ala Gly Ala Lys Ala Ala Leu Asp Gly Thr
    130                 135                 140                 
Pro Gly Met Ile Gly Tyr Gly Met Ala Lys Gly Ala Val His Gln Leu
145                 150                 155                 160 
Cys Gln Ser Leu Ala Gly Lys Asn Ser Gly Met Pro Pro Gly Ala Ala
                165                 170                 175     
Ala Ile Ala Val Leu Pro Val Thr Leu Asp Thr Pro Met Asn Arg Lys
            180                 185                 190         
Ser Met Pro Glu Ala Asp Phe Ser Ser Trp Thr Pro Leu Glu Phe Leu
        195                 200                 205             
Val Glu Thr Phe His Asp Trp Ile Thr Gly Lys Asn Arg Pro Ser Ser
    210                 215                 220                 
Gly Ser Leu Ile Gln Val Val Thr Thr Glu Gly Arg Thr Glu Leu Thr
225                 230                 235                 240 
Pro Ala Tyr Phe
                


<210> 2252
<211> 697
<212> PRT
<213> Homo sapiens

<400> 2252
Met Gln Thr Gln Glu Ile Leu Arg Ile Leu Arg Leu Pro Glu Leu Gly
 1               5                  10                  15      
Asp Leu Gly Gln Phe Phe Arg Ser Leu Ser Ala Thr Thr Leu Val Ser
            20                  25                  30          
Met Gly Ala Leu Ala Ala Ile Leu Ala Tyr Trp Phe Thr His Arg Pro
        35                  40                  45              
Lys Ala Leu Gln Pro Pro Cys Asn Leu Leu Met Gln Ser Glu Glu Val
    50                  55                  60                  
Glu Asp Ser Gly Gly Ala Arg Arg Ser Val Ile Gly Ser Gly Pro Gln
65                  70                  75                  80  
Leu Leu Thr His Tyr Tyr Asp Asp Ala Arg Thr Met Tyr Gln Val Phe
                85                  90                  95      
Arg Arg Gly Leu Ser Ile Ser Gly Asn Gly Pro Cys Leu Gly Phe Arg
            100                 105                 110         
Lys Pro Lys Gln Pro Tyr Gln Trp Leu Ser Tyr Gln Glu Val Ala Asp
        115                 120                 125             
Arg Ala Glu Phe Leu Gly Ser Gly Leu Leu Gln His Asn Cys Lys Ala
    130                 135                 140                 
Cys Thr Asp Gln Phe Ile Gly Val Phe Ala Gln Asn Arg Pro Glu Trp
145                 150                 155                 160 
Ile Ile Val Glu Leu Ala Cys Tyr Thr Tyr Ser Met Val Val Val Pro
                165                 170                 175     
Leu Tyr Asp Thr Leu Gly Pro Gly Ala Ile Arg Tyr Ile Ile Asn Thr
            180                 185                 190         
Ala Asp Ile Ser Thr Val Ile Val Asp Lys Pro Gln Lys Ala Val Leu
        195                 200                 205             
Leu Leu Glu His Val Glu Arg Lys Glu Thr Pro Gly Leu Lys Leu Ile
    210                 215                 220                 
Ile Leu Met Asp Pro Phe Glu Glu Ala Leu Lys Glu Arg Gly Gln Lys
225                 230                 235                 240 
Cys Gly Val Val Ile Lys Ser Met Gln Ala Val Glu Asp Cys Gly Gln
                245                 250                 255     
Glu Asn His Gln Ala Pro Val Pro Pro Gln Pro Asp Asp Leu Ser Ile
            260                 265                 270         
Val Cys Phe Thr Ser Gly Thr Thr Gly Asn Pro Lys Gly Ala Met Leu
        275                 280                 285             
Thr His Gly Asn Val Val Ala Asp Phe Ser Gly Phe Leu Lys Val Thr
    290                 295                 300                 
Glu Ser Gln Trp Ala Pro Thr Cys Ala Asp Val His Ile Ser Tyr Leu
305                 310                 315                 320 
Pro Leu Ala His Met Phe Glu Arg Met Val Gln Ser Val Val Tyr Cys
                325                 330                 335     
His Gly Gly Arg Val Gly Phe Phe Gln Gly Asp Ile Arg Leu Leu Ser
            340                 345                 350         
Asp Asp Met Lys Ala Leu Cys Pro Thr Ile Phe Pro Val Val Pro Arg
        355                 360                 365             
Leu Leu Asn Arg Met Tyr Asp Lys Ile Phe Ser Gln Ala Asn Thr Pro
    370                 375                 380                 
Leu Lys Arg Trp Leu Leu Glu Phe Ala Ala Lys Arg Lys Gln Ala Glu
385                 390                 395                 400 
Val Arg Ser Gly Ile Ile Arg Asn Asp Ser Ile Trp Asp Glu Leu Phe
                405                 410                 415     
Phe Asn Lys Ile Gln Ala Ser Leu Gly Gly Cys Val Arg Met Ile Val
            420                 425                 430         
Thr Gly Ala Ala Pro Ala Ser Pro Thr Val Leu Gly Phe Leu Arg Ala
        435                 440                 445             
Ala Leu Gly Cys Gln Val Tyr Glu Gly Tyr Gly Gln Thr Glu Cys Thr
    450                 455                 460                 
Ala Gly Cys Thr Phe Thr Thr Pro Gly Asp Trp Thr Ser Gly His Val
465                 470                 475                 480 
Gly Ala Pro Leu Pro Cys Asn His Ile Lys Leu Val Asp Val Glu Glu
                485                 490                 495     
Leu Asn Tyr Trp Ala Cys Lys Gly Glu Gly Glu Ile Cys Val Arg Gly
            500                 505                 510         
Pro Asn Val Phe Lys Gly Tyr Leu Lys Asp Pro Asp Arg Thr Lys Glu
        515                 520                 525             
Ala Leu Asp Ser Asp Gly Trp Leu His Thr Gly Asp Ile Gly Lys Trp
    530                 535                 540                 
Leu Pro Ala Gly Thr Leu Lys Ile Ile Asp Arg Lys Lys His Ile Phe
545                 550                 555                 560 
Lys Leu Ala Gln Gly Glu Tyr Val Ala Pro Glu Lys Ile Glu Asn Ile
                565                 570                 575     
Tyr Ile Arg Ser Gln Pro Val Ala Gln Ile Tyr Val His Gly Asp Ser
            580                 585                 590         
Leu Lys Ala Phe Leu Val Gly Ile Val Val Pro Asp Pro Glu Val Met
        595                 600                 605             
Pro Ser Trp Ala Gln Lys Arg Gly Ile Glu Gly Thr Tyr Ala Asp Leu
    610                 615                 620                 
Cys Thr Asn Lys Asp Leu Lys Lys Ala Ile Leu Glu Asp Met Val Arg
625                 630                 635                 640 
Leu Gly Lys Glu Ser Gly Leu His Ser Phe Glu Gln Val Lys Ala Ile
                645                 650                 655     
His Ile His Ser Asp Met Phe Ser Val Gln Asn Gly Leu Leu Thr Pro
            660                 665                 670         
Thr Leu Lys Ala Lys Arg Pro Glu Leu Arg Glu Tyr Phe Lys Lys Gln
        675                 680                 685             
Ile Glu Glu Leu Tyr Ser Ile Ser Met
    690                 695         


<210> 2253
<211> 1270
<212> PRT
<213> Homo sapiens

<400> 2253
Met Asp Leu Leu Thr Arg Glu Asn Val Ala Leu Lys Val Glu Ser Ala
 1               5                  10                  15      
Gln Gln Pro Lys Gln Val Leu Lys Met Glu Val Ala Val Leu Lys Lys
            20                  25                  30          
Leu Gln Gly Lys Asp His Val Cys Arg Phe Ile Gly Cys Gly Arg Asn
        35                  40                  45              
Glu Lys Phe Asn Tyr Val Val Met Gln Leu Gln Gly Arg Asn Leu Ala
    50                  55                  60                  
Asp Leu Arg Arg Ser Gln Pro Arg Gly Thr Phe Thr Leu Ser Thr Thr
65                  70                  75                  80  
Leu Arg Leu Gly Lys Gln Ile Leu Glu Ser Ile Glu Ala Ile His Ser
                85                  90                  95      
Val Gly Phe Leu His Arg Asp Ile Lys Pro Ser Asn Phe Ala Met Gly
            100                 105                 110         
Arg Leu Pro Ser Thr Tyr Arg Lys Cys Tyr Met Leu Asp Phe Gly Leu
        115                 120                 125             
Ala Arg Gln Tyr Thr Asn Thr Thr Gly Asp Val Arg Pro Pro Arg Asn
    130                 135                 140                 
Val Ala Gly Phe Arg Gly Thr Val Arg Tyr Ala Ser Val Asn Ala His
145                 150                 155                 160 
Lys Asn Arg Glu Met Gly Arg His Asp Asp Leu Trp Ser Leu Phe Tyr
                165                 170                 175     
Met Leu Val Glu Phe Ala Val Gly Gln Leu Pro Trp Arg Lys Ile Lys
            180                 185                 190         
Asp Lys Glu Gln Val Gly Met Ile Lys Glu Lys Tyr Glu His Arg Met
        195                 200                 205             
Leu Leu Lys His Met Pro Ser Glu Phe His Leu Phe Leu Asp His Ile
    210                 215                 220                 
Ala Ser Leu Asp Tyr Phe Thr Lys Pro Asp Tyr Gln Leu Ile Met Ser
225                 230                 235                 240 
Val Phe Glu Asn Ser Met Lys Glu Arg Gly Ile Ala Glu Asn Glu Ala
                245                 250                 255     
Phe Asp Trp Glu Lys Ala Gly Thr Asp Ala Leu Leu Ser Thr Ser Thr
            260                 265                 270         
Ser Thr Pro Pro Gln Gln Asn Thr Arg Gln Thr Ala Ala Met Phe Gly
        275                 280                 285             
Val Val Asn Val Thr Pro Val Pro Gly Asp Leu Leu Arg Glu Asn Thr
    290                 295                 300                 
Glu Asp Val Leu Gln Gly Glu His Leu Ser Asp Gln Glu Asn Ala Pro
305                 310                 315                 320 
Pro Ile Leu Pro Gly Arg Pro Ser Glu Gly Leu Gly Pro Ser Pro His
                325                 330                 335     
Leu Val Pro His Pro Gly Gly Pro Glu Ala Glu Val Trp Glu Glu Thr
            340                 345                 350         
Asp Val Asn Arg Asn Lys Leu Arg Ile Asn Ile Gly Lys Ser Pro Cys
        355                 360                 365             
Val Glu Glu Glu Gln Ser Arg Gly Met Gly Val Pro Ser Ser Pro Val
    370                 375                 380                 
Arg Ala Pro Pro Asp Ser Pro Thr Thr Pro Val Arg Ser Leu Arg Tyr
385                 390                 395                 400 
Arg Arg Val Asn Ser Pro Glu Ser Glu Arg Leu Ser Thr Ala Asp Gly
                405                 410                 415     
Arg Val Glu Leu Pro Glu Arg Arg Ser Arg Met Asp Leu Pro Gly Ser
            420                 425                 430         
Pro Ser Arg Gln Ala Cys Ser Ser Gln Pro Ala Gln Met Leu Ser Val
        435                 440                 445             
Asp Thr Gly His Ala Asp Arg Gln Ala Ser Gly Arg Met Asp Val Ser
    450                 455                 460                 
Ala Ser Val Glu Gln Glu Ala Leu Ser Asn Ala Phe Arg Ser Val Pro
465                 470                 475                 480 
Leu Ala Glu Glu Glu Asp Phe Asp Ser Lys Glu Trp Val Ile Ile Asp
                485                 490                 495     
Lys Glu Thr Glu Leu Lys Asp Phe Pro Pro Gly Ala Glu Pro Ser Thr
            500                 505                 510         
Ser Gly Thr Thr Asp Glu Glu Pro Glu Glu Leu Arg Pro Leu Pro Glu
        515                 520                 525             
Glu Gly Glu Glu Arg Arg Arg Leu Gly Ala Glu Pro Thr Val Arg Pro
    530                 535                 540                 
Arg Gly Arg Ser Met Gln Ala Leu Ala Glu Glu Asp Leu Gln His Leu
545                 550                 555                 560 
Pro Pro Gln Pro Leu Pro Pro Gln Leu Ser Gln Gly Asp Gly Arg Ser
                565                 570                 575     
Glu Thr Ser Gln Pro Pro Thr Pro Gly Ser Pro Ser His Ser Pro Leu
            580                 585                 590         
His Ser Gly Pro Arg Pro Arg Arg Arg Glu Ser Asp Pro Thr Gly Pro
        595                 600                 605             
Gln Arg Gln Val Phe Ser Val Ala Pro Pro Phe Glu Val Asn Gly Leu
    610                 615                 620                 
Pro Arg Ala Val Pro Leu Ser Leu Pro Tyr Gln Asp Phe Lys Arg Asp
625                 630                 635                 640 
Leu Ser Asp Tyr Arg Glu Arg Ala Arg Leu Leu Asn Arg Val Arg Arg
                645                 650                 655     
Val Gly Phe Ser His Met Leu Leu Thr Thr Pro Gln Val Pro Leu Ala
            660                 665                 670         
Pro Val Gln Pro Gln Ala Asn Gly Lys Glu Glu Glu Glu Glu Glu Glu
        675                 680                 685             
Glu Asp Glu Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu
    690                 695                 700                 
Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
705                 710                 715                 720 
Ala Ala Ala Ala Val Ala Leu Gly Glu Val Leu Gly Pro Arg Ser Gly
                725                 730                 735     
Ser Ser Ser Glu Gly Ser Glu Arg Ser Thr Asp Arg Ser Gln Glu Gly
            740                 745                 750         
Ala Pro Ser Thr Leu Leu Ala Asp Asp Gln Lys Glu Ser Arg Gly Arg
        755                 760                 765             
Ala Ser Met Ala Asp Gly Asp Leu Glu Pro Glu Glu Gly Ser Lys Thr
    770                 775                 780                 
Leu Val Leu Val Ser Pro Gly Asp Met Lys Lys Ser Pro Val Thr Ala
785                 790                 795                 800 
Glu Leu Ala Pro Asp Pro Asp Leu Gly Thr Leu Ala Ala Leu Thr Pro
                805                 810                 815     
Gln His Glu Arg Pro Gln Pro Thr Gly Ser Gln Leu Asp Val Ser Glu
            820                 825                 830         
Pro Gly Thr Leu Ser Ser Val Leu Lys Ser Glu Pro Lys Pro Pro Gly
        835                 840                 845             
Pro Gly Ala Gly Leu Gly Ala Gly Thr Val Thr Thr Gly Val Gly Gly
    850                 855                 860                 
Val Ala Val Thr Ser Ser Pro Phe Thr Lys Val Glu Arg Thr Phe Val
865                 870                 875                 880 
His Ile Ala Glu Lys Thr His Leu Asn Val Met Ser Ser Gly Gly Gln
                885                 890                 895     
Ala Leu Arg Ser Glu Glu Phe Ser Ala Gly Gly Glu Leu Gly Leu Glu
            900                 905                 910         
Leu Ala Ser Asp Gly Gly Ala Val Glu Glu Gly Ala Arg Ala Pro Leu
        915                 920                 925             
Glu Asn Gly Leu Ala Leu Ser Gly Leu Asn Gly Ala Glu Ile Glu Gly
    930                 935                 940                 
Ser Ala Leu Ser Gly Ala Pro Arg Glu Thr Pro Ser Glu Met Ala Thr
945                 950                 955                 960 
Asn Ser Leu Pro Asn Gly Pro Ala Leu Ala Asp Gly Pro Ala Pro Val
                965                 970                 975     
Ser Pro Leu Glu Pro Ser Pro Glu Lys Val Ala Thr Ile Ser Pro Arg
            980                 985                 990         
Arg His Ala Met Pro Gly Ser Arg Pro Arg Ser Arg Ile Pro Val Leu
        995                 1000                1005            
Leu Ser Glu Glu Asp Thr Gly Ser Glu Pro Ser Gly Ser Leu Ser Ala
    1010                1015                1020                
Lys Glu Arg Trp Ser Lys Arg Ala Arg Pro Gln Gln Asp Leu Ala Arg
1025                1030                1035                1040
Leu Val Met Glu Lys Arg Gln Gly Arg Leu Leu Leu Arg Leu Ala Ser
                1045                1050                1055    
Gly Ala Ser Ser Ser Ser Ser Glu Glu Gln Arg Arg Ala Ser Glu Thr
            1060                1065                1070        
Leu Ser Gly Thr Gly Ser Glu Glu Asp Thr Pro Ala Ser Glu Pro Ala
        1075                1080                1085            
Ala Ala Leu Pro Arg Lys Ser Gly Arg Ala Ala Ala Thr Arg Ser Arg
    1090                1095                1100                
Ile Pro Arg Pro Ile Gly Leu Arg Met Pro Met Pro Val Ala Ala Gln
1105                1110                1115                1120
Gln Pro Ala Ser Arg Ser His Gly Ala Ala Pro Ala Leu Asp Thr Ala
                1125                1130                1135    
Ile Thr Ser Arg Leu Gln Leu Gln Thr Pro Pro Gly Ser Ala Thr Ala
            1140                1145                1150        
Ala Asp Leu Arg Pro Lys Gln Pro Pro Gly Arg Gly Leu Gly Pro Gly
        1155                1160                1165            
Arg Ala Gln Ala Gly Ala Arg Pro Pro Ala Pro Arg Ser Pro Arg Leu
    1170                1175                1180                
Pro Ala Ser Thr Ser Ala Ala Arg Asn Ala Ser Ala Ser Pro Arg Ser
1185                1190                1195                1200
Gln Ser Leu Ser Arg Arg Glu Ser Pro Ser Pro Ser His Gln Ala Arg
                1205                1210                1215    
Pro Gly Val Pro Pro Pro Arg Gly Val Pro Pro Ala Arg Ala Gln Pro
            1220                1225                1230        
Asp Gly Thr Pro Ser Pro Gly Gly Ser Lys Lys Gly Pro Arg Gly Lys
        1235                1240                1245            
Leu Gln Ala Gln Arg Ala Thr Thr Lys Gly Arg Ala Gly Gly Ala Glu
    1250                1255                1260                
Gly Arg Ala Gly Ala Arg
1265                1270


<210> 2254
<211> 671
<212> PRT
<213> Homo sapiens

<400> 2254
Met Gln Pro Asp Met Ser Leu Asn Val Ile Lys Met Lys Ser Ser Asp
 1               5                  10                  15      
Phe Leu Glu Ser Ala Glu Leu Asp Ser Gly Gly Phe Gly Lys Val Ser
            20                  25                  30          
Leu Cys Phe His Arg Thr Gln Gly Leu Met Ile Met Lys Thr Val Tyr
        35                  40                  45              
Lys Gly Pro Asn Cys Ile Glu His Asn Glu Ala Leu Leu Glu Glu Ala
    50                  55                  60                  
Lys Met Met Asn Arg Leu Arg His Ser Arg Val Val Lys Leu Leu Gly
65                  70                  75                  80  
Val Ile Ile Glu Glu Gly Lys Tyr Ser Leu Val Met Glu Tyr Met Glu
                85                  90                  95      
Lys Gly Asn Leu Met His Val Leu Lys Ala Glu Met Ser Thr Pro Leu
            100                 105                 110         
Ser Val Lys Gly Arg Ile Ile Leu Glu Ile Ile Glu Gly Met Cys Tyr
        115                 120                 125             
Leu His Gly Lys Gly Val Ile His Lys Asp Leu Lys Pro Glu Asn Ile
    130                 135                 140                 
Leu Val Asp Asn Asp Phe His Ile Lys Ile Ala Asp Leu Gly Leu Ala
145                 150                 155                 160 
Ser Phe Lys Met Trp Ser Lys Leu Asn Asn Glu Glu His Asn Glu Leu
                165                 170                 175     
Arg Glu Val Asp Gly Thr Ala Lys Lys Asn Gly Gly Thr Leu Tyr Tyr
            180                 185                 190         
Met Ala Pro Glu His Leu Asn Asp Val Asn Ala Lys Pro Thr Glu Lys
        195                 200                 205             
Ser Asp Val Tyr Ser Phe Ala Val Val Leu Trp Ala Ile Phe Ala Asn
    210                 215                 220                 
Lys Glu Pro Tyr Glu Asn Ala Ile Cys Glu Gln Gln Leu Ile Met Cys
225                 230                 235                 240 
Ile Lys Ser Gly Asn Arg Pro Asp Val Asp Asp Ile Thr Glu Tyr Cys
                245                 250                 255     
Pro Arg Glu Ile Ile Ser Leu Met Lys Leu Cys Trp Glu Ala Asn Pro
            260                 265                 270         
Glu Ala Arg Pro Thr Phe Pro Gly Ile Glu Glu Lys Phe Arg Pro Phe
        275                 280                 285             
Tyr Leu Ser Gln Leu Glu Glu Ser Val Glu Glu Asp Val Lys Ser Leu
    290                 295                 300                 
Lys Lys Glu Tyr Ser Asn Glu Asn Ala Val Val Lys Arg Met Gln Ser
305                 310                 315                 320 
Leu Gln Leu Asp Cys Val Ala Val Pro Ser Ser Arg Ser Asn Ser Ala
                325                 330                 335     
Thr Glu Gln Pro Gly Ser Leu His Ser Ser Gln Gly Leu Gly Met Gly
            340                 345                 350         
Pro Val Glu Glu Ser Trp Phe Ala Pro Ser Leu Glu His Pro Gln Glu
        355                 360                 365             
Glu Asn Glu Pro Ser Leu Gln Ser Lys Leu Gln Asp Glu Ala Asn Tyr
    370                 375                 380                 
His Leu Tyr Gly Ser Arg Met Asp Arg Gln Thr Lys Gln Gln Pro Arg
385                 390                 395                 400 
Gln Asn Val Ala Tyr Asn Arg Glu Glu Glu Arg Arg Arg Arg Val Ser
                405                 410                 415     
His Asp Pro Phe Ala Gln Gln Arg Pro Tyr Glu Asn Phe Gln Asn Thr
            420                 425                 430         
Glu Gly Lys Gly Thr Ala Tyr Ser Ser Ala Ala Ser His Gly Asn Ala
        435                 440                 445             
Val His Gln Pro Ser Gly Leu Thr Ser Gln Pro Gln Val Leu Tyr Gln
    450                 455                 460                 
Asn Asn Gly Leu Tyr Ser Ser His Gly Phe Gly Thr Arg Pro Leu Asp
465                 470                 475                 480 
Pro Gly Thr Ala Gly Pro Arg Val Trp Tyr Arg Pro Ile Pro Ser His
                485                 490                 495     
Met Pro Ser Leu His Asn Ile Pro Val Pro Glu Thr Asn Tyr Leu Gly
            500                 505                 510         
Asn Thr Pro Thr Met Pro Phe Ser Ser Leu Pro Pro Thr Asp Glu Ser
        515                 520                 525             
Ile Lys Tyr Thr Ile Tyr Asn Ser Thr Gly Ile Gln Ile Gly Ala Tyr
    530                 535                 540                 
Asn Tyr Met Glu Ile Gly Gly Thr Ser Ser Ser Leu Leu Asp Ser Thr
545                 550                 555                 560 
Asn Thr Asn Phe Lys Glu Glu Pro Ala Ala Lys Tyr Gln Ala Ile Phe
                565                 570                 575     
Asp Asn Thr Thr Ser Leu Thr Asp Lys His Leu Asp Pro Ile Arg Glu
            580                 585                 590         
Asn Leu Gly Lys His Trp Lys Asn Cys Ala Arg Lys Leu Gly Phe Thr
        595                 600                 605             
Gln Ser Gln Ile Asp Glu Ile Asp His Asp Tyr Glu Arg Asp Gly Leu
    610                 615                 620                 
Lys Glu Lys Val Tyr Gln Met Leu Gln Lys Trp Val Met Arg Glu Gly
625                 630                 635                 640 
Ile Lys Gly Ala Thr Val Gly Lys Leu Ala Gln Ala Leu His Gln Cys
                645                 650                 655     
Ser Arg Ile Asp Leu Leu Ser Ser Leu Ile Tyr Val Ser Gln Asn
            660                 665                 670     


<210> 2255
<211> 1103
<212> PRT
<213> Homo sapiens

<400> 2255
Met Gln Arg Val Ala Trp His Ile Asn Asp Met Lys Arg Lys His Glu
 1               5                  10                  15      
His Ala Val Arg Leu Gln Glu Ile Gln Ser Leu Leu Thr Asn Trp Lys
            20                  25                  30          
Gly Pro Asp Leu Thr Ser Tyr Gly Glu Leu Val Leu Glu Gly Thr Phe
        35                  40                  45              
Arg Ile Gln Arg Ala Lys Asn Glu Arg Thr Leu Phe Leu Phe Asp Lys
    50                  55                  60                  
Leu Leu Leu Ile Thr Lys Lys Arg Asp Asp Thr Phe Thr Tyr Lys Ala
65                  70                  75                  80  
His Ile Leu Cys Gly Asn Leu Met Leu Val Glu Val Ile Pro Lys Glu
                85                  90                  95      
Pro Leu Ser Phe Ser Val Phe His Tyr Lys Asn Pro Lys Leu Gln His
            100                 105                 110         
Thr Val Gln Ala Lys Ser Gln Gln Asp Lys Arg Leu Trp Val Leu His
        115                 120                 125             
Leu Lys Arg Leu Ile Leu Glu Asn His Ala Ala Lys Ile Pro Ala Lys
    130                 135                 140                 
Ala Lys Gln Ala Ile Leu Glu Met Asp Ala Ile His His Pro Gly Phe
145                 150                 155                 160 
Cys Tyr Ser Pro Glu Gly Gly Thr Lys Ala Leu Phe Gly Ser Lys Glu
                165                 170                 175     
Gly Ser Ala Pro Tyr Arg Leu Arg Arg Lys Ser Glu Pro Ser Ser Arg
            180                 185                 190         
Ser His Lys Val Leu Lys Thr Ser Glu Thr Ala Gln Asp Ile Gln Lys
        195                 200                 205             
Val Ser Arg Glu Glu Gly Ser Pro Gln Leu Ser Ser Ala Arg Pro Ser
    210                 215                 220                 
Pro Ala Gln Arg Asn Ser Gln Pro Ser Ser Ser Thr Met Ile Ser Val
225                 230                 235                 240 
Leu Arg Ala Gly Gly Ala Leu Arg Asn Ile Trp Thr Asp His Gln Ile
                245                 250                 255     
Arg Gln Ala Leu Phe Pro Ser Arg Arg Ser Pro Gln Glu Asn Glu Asp
            260                 265                 270         
Asp Glu Asp Asp Tyr Gln Met Phe Val Pro Ser Phe Ser Ser Ser Asp
        275                 280                 285             
Leu Asn Ser Thr Arg Leu Cys Glu Asp Ser Thr Ser Ser Arg Pro Cys
    290                 295                 300                 
Ser Trp His Met Gly Gln Met Glu Ser Thr Glu Thr Ser Ser Ser Gly
305                 310                 315                 320 
His Arg Ile Val Arg Arg Ala Ser Ser Ala Gly Glu Ser Asn Thr Cys
                325                 330                 335     
Pro Pro Glu Ile Gly Thr Ser Asp Arg Thr Arg Glu Leu Gln Asn Ser
            340                 345                 350         
Pro Lys Thr Glu Gly Gln Glu Glu Met Thr Pro Phe Gly Ser Ser Ile
        355                 360                 365             
Glu Leu Thr Ile Asp Asp Ile Asp His Val Tyr Asp Asn Ile Ser Tyr
    370                 375                 380                 
Glu Asp Leu Lys Leu Met Val Ala Lys Arg Glu Glu Ala Glu Ser Thr
385                 390                 395                 400 
Pro Ser Lys Ser Ala Arg Asp Ser Val Arg Pro Lys Ser Thr Pro Glu
                405                 410                 415     
Leu Ala Phe Thr Lys Arg Gln Ala Gly His Ser Lys Gly Ser Leu Tyr
            420                 425                 430         
Ala Gln Thr Asp Gly Thr Leu Ser Gly Gly Glu Ala Ser Ser Gln Ser
        435                 440                 445             
Thr His Glu Leu Gln Ala Val Glu Glu Asn Ile Tyr Asp Thr Ile Gly
    450                 455                 460                 
Leu Pro Asp Pro Pro Ser Leu Gly Phe Lys Cys Ser Ser Leu Lys Arg
465                 470                 475                 480 
Ala Lys Arg Ser Thr Phe Leu Gly Leu Glu Ala Asp Phe Val Cys Cys
                485                 490                 495     
Asp Ser Leu Arg Pro Phe Val Ser Gln Asp Ser Leu Gln Leu Ser Glu
            500                 505                 510         
Asp Glu Ala Pro Tyr His Gln Ala Thr Pro Asp His Gly Tyr Leu Ser
        515                 520                 525             
Leu Leu Tyr Asp Ser Pro Ser Gly Asn Leu Ser Met Pro His Lys Pro
    530                 535                 540                 
Val Ser Asp Lys Leu Ser Glu Glu Val Asp Glu Ile Trp Asn Asp Leu
545                 550                 555                 560 
Glu Asn Tyr Ile Lys Lys Asn Glu Asp Lys Ala Arg Asp Arg Leu Leu
                565                 570                 575     
Ala Ala Phe Pro Val Ser Lys Asp Asp Val Pro Asp Arg Leu His Ala
            580                 585                 590         
Glu Ser Thr Pro Glu Leu Ser Arg Asp Val Gly Arg Ser Val Ser Thr
        595                 600                 605             
Leu Ser Leu Pro Glu Ser Gln Ala Leu Leu Thr Pro Val Lys Ser Arg
    610                 615                 620                 
Ala Gly Arg Ala Ser Arg Ala Asn Cys Pro Phe Glu Glu Asp Leu Ile
625                 630                 635                 640 
Ser Lys Glu Gly Ser Phe Met Ser Leu Asn Arg Leu Ser Leu Ala Ser
                645                 650                 655     
Glu Met Pro Leu Met Asp Asn Pro Tyr Asp Leu Ala Asn Ser Gly Leu
            660                 665                 670         
Ser Gln Thr Asp Pro Glu Asn Pro Asp Leu Gly Met Glu Ala Thr Asp
        675                 680                 685             
Lys Thr Lys Ser Arg Val Phe Met Met Ala Arg Gln Tyr Ser Gln Lys
    690                 695                 700                 
Ile Lys Lys Ala Asn Gln Leu Leu Lys Val Lys Ser Leu Glu Leu Glu
705                 710                 715                 720 
Gln Pro Pro Ala Ser Gln His Gln Lys Ser Met His Lys Asp Leu Ala
                725                 730                 735     
Ala Ile Leu Glu Glu Lys Lys Gln Gly Gly Pro Ala Ile Gly Ala Arg
            740                 745                 750         
Ile Ala Glu Tyr Ser Gln Leu Tyr Asp Gln Ile Val Phe Arg Glu Ser
        755                 760                 765             
Pro Leu Lys Ile Gln Lys Asp Gly Trp Ala Ser Pro Gln Glu Ser Ser
    770                 775                 780                 
Leu Leu Arg Ser Val Ser Pro Ser Gln Val His His Gly Ser Gly Asp
785                 790                 795                 800 
Trp Leu Leu His Ser Thr Tyr Ser Asn Gly Glu Leu Ala Asp Phe Cys
                805                 810                 815     
Leu Pro Pro Glu Gln Asp Leu Arg Ser Arg Tyr Pro Thr Phe Glu Ile
            820                 825                 830         
Asn Thr Lys Ser Thr Pro Arg Gln Leu Ser Ala Ala Cys Ser Val Pro
        835                 840                 845             
Ser Leu Gln Thr Ser Asp Pro Leu Pro Gly Ser Val Gln Arg Cys Ser
    850                 855                 860                 
Val Val Val Ser Gln Pro Asn Lys Glu Asn Trp Cys Gln Asp His Leu
865                 870                 875                 880 
Tyr Asn Ser Leu Gly Arg Lys Gly Ile Ser Ala Lys Ser Gln Pro Tyr
                885                 890                 895     
His Arg Ser Gln Ser Ser Ser Ser Val Leu Ile Asn Lys Ser Met Asp
            900                 905                 910         
Ser Ile Asn Tyr Pro Ser Asp Val Gly Lys Gln Gln Leu Leu Ser Leu
        915                 920                 925             
His Arg Ser Ser Arg Cys Glu Ser His Gln Asp Leu Leu Pro Asp Ile
    930                 935                 940                 
Ala Asp Ser His Gln Gln Gly Thr Glu Lys Leu Ser Asp Leu Thr Leu
945                 950                 955                 960 
Gln Asp Ser Gln Lys Val Val Val Val Asn Arg Asn Leu Pro Leu Asn
                965                 970                 975     
Ala Gln Ile Ala Thr Gln Asn Tyr Phe Ser Asn Phe Lys Glu Thr Asp
            980                 985                 990         
Gly Asp Glu Asp Asp Tyr Val Glu Ile Lys Ser Glu Glu Asp Glu Ser
        995                 1000                1005            
Glu Leu Glu Leu Ser His Asn Arg Arg Arg Lys Ser Asp Ser Lys Phe
    1010                1015                1020                
Val Asp Ala Asp Phe Ser Asp Asn Val Cys Ser Gly Asn Thr Leu His
1025                1030                1035                1040
Ser Leu Asn Ser Pro Arg Thr Pro Lys Lys Pro Val Asn Ser Lys Leu
                1045                1050                1055    
Gly Leu Ser Pro Tyr Leu Thr Pro Tyr Asn Asp Ser Asp Lys Leu Asn
            1060                1065                1070        
Asp Tyr Leu Trp Arg Gly Pro Ser Pro Asn Gln Gln Asn Ile Val Gln
        1075                1080                1085            
Ser Leu Arg Glu Lys Phe Gln Cys Leu Ser Ser Ser Ser Phe Ala
    1090                1095                1100            


<210> 2256
<211> 697
<212> PRT
<213> Homo sapiens

<400> 2256
Met Ala Glu Thr Ser Pro Glu Pro Ser Gly Gln Leu Val Val His Ser
 1               5                  10                  15      
Asp Ala His Ser Asp Thr Val Leu Ala Ser Phe Glu Asp Gln Arg Lys
            20                  25                  30          
Lys Gly Phe Leu Cys Asp Ile Thr Leu Ile Val Glu Asn Val His Phe
        35                  40                  45              
Arg Ala His Lys Ala Leu Leu Ala Ala Ser Ser Glu Tyr Phe Ser Met
    50                  55                  60                  
Met Phe Ala Glu Glu Gly Glu Ile Gly Gln Ser Ile Tyr Met Leu Glu
65                  70                  75                  80  
Gly Met Val Ala Asp Thr Phe Gly Ile Leu Leu Glu Phe Ile Tyr Thr
                85                  90                  95      
Gly Tyr Leu His Ala Ser Glu Lys Ser Thr Glu Gln Ile Leu Ala Thr
            100                 105                 110         
Ala Gln Phe Leu Lys Val Tyr Asp Leu Val Lys Ala Tyr Thr Asp Phe
        115                 120                 125             
Gln Asn Asn His Ser Ser Pro Lys Pro Thr Thr Leu Asn Thr Ala Gly
    130                 135                 140                 
Ala Pro Val Val Val Ile Ser Asn Lys Lys Asn Asp Pro Pro Lys Arg
145                 150                 155                 160 
Lys Arg Gly Arg Pro Lys Lys Val Asn Thr Leu Gln Glu Glu Lys Ser
                165                 170                 175     
Glu Leu Ala Ala Glu Glu Glu Ile Gln Leu Arg Val Asn Asn Ser Val
            180                 185                 190         
Gln Asn Arg Gln Asn Phe Val Val Lys Gly Asp Ser Gly Val Leu Asn
        195                 200                 205             
Glu Gln Ile Ala Ala Lys Glu Lys Glu Glu Ser Glu Pro Thr Cys Glu
    210                 215                 220                 
Pro Ser Arg Glu Glu Glu Met Pro Val Glu Lys Asp Glu Asn Tyr Asp
225                 230                 235                 240 
Pro Lys Thr Glu Asp Gly Gln Ala Ser Gln Ser Arg Tyr Ser Lys Arg
                245                 250                 255     
Arg Ile Trp Arg Ser Val Lys Leu Lys Asp Tyr Lys Leu Val Gly Asp
            260                 265                 270         
Gln Glu Asp His Gly Ser Ala Lys Arg Ile Cys Gly Arg Arg Lys Arg
        275                 280                 285             
Pro Gly Gly Pro Glu Ala Arg Cys Lys Asp Cys Gly Lys Val Phe Lys
    290                 295                 300                 
Tyr Asn His Phe Leu Ala Ile His Gln Arg Ser His Thr Gly Glu Arg
305                 310                 315                 320 
Pro Phe Lys Cys Asn Glu Cys Gly Lys Gly Phe Ala Gln Lys His Ser
                325                 330                 335     
Leu Gln Val His Thr Arg Met His Thr Gly Glu Arg Pro Tyr Thr Cys
            340                 345                 350         
Thr Val Cys Ser Lys Ala Leu Thr Thr Lys His Ser Leu Leu Glu His
        355                 360                 365             
Met Ser Leu His Ser Gly Gln Lys Ser Phe Thr Cys Asp Gln Cys Gly
    370                 375                 380                 
Lys Tyr Phe Ser Gln Asn Arg Gln Leu Lys Ser His Tyr Arg Val His
385                 390                 395                 400 
Thr Gly His Ser Leu Pro Glu Cys Lys Asp Cys His Arg Lys Phe Met
                405                 410                 415     
Asp Val Ser Gln Leu Lys Lys His Leu Arg Thr His Thr Gly Glu Lys
            420                 425                 430         
Pro Phe Thr Cys Glu Ile Cys Gly Lys Ser Phe Thr Ala Lys Ser Ser
        435                 440                 445             
Leu Gln Thr His Ile Arg Ile His Arg Gly Glu Lys Pro Tyr Ser Cys
    450                 455                 460                 
Gly Ile Cys Gly Lys Ser Phe Ser Asp Ser Ser Ala Lys Arg Arg His
465                 470                 475                 480 
Cys Ile Leu His Thr Gly Lys Lys Pro Phe Ser Cys Pro Glu Cys Asn
                485                 490                 495     
Leu Gln Phe Ala Arg Leu Asp Asn Leu Lys Ala His Leu Lys Ile His
            500                 505                 510         
Ser Lys Glu Lys His Ala Ser Asp Ala Ser Ser Ile Ser Gly Ser Ser
        515                 520                 525             
Asn Thr Glu Glu Val Arg Asn Ile Leu Gln Leu Gln Pro Tyr Gln Leu
    530                 535                 540                 
Ser Thr Ser Gly Glu Gln Glu Ile Gln Leu Leu Val Thr Asp Ser Val
545                 550                 555                 560 
His Asn Ile Asn Phe Met Pro Gly Pro Ser Gln Gly Ile Ser Ile Val
                565                 570                 575     
Thr Ala Glu Ser Ser Gln Asn Met Thr Ala Asp Gln Ala Ala Asn Leu
            580                 585                 590         
Thr Leu Leu Thr Gln Gln Pro Glu Gln Leu Gln Asn Leu Ile Leu Ser
        595                 600                 605             
Ala Gln Gln Glu Gln Thr Glu His Ile Gln Ser Leu Asn Met Ile Glu
    610                 615                 620                 
Ser Gln Met Gly Pro Ser Gln Thr Glu Pro Val His Val Ile Thr Leu
625                 630                 635                 640 
Ser Lys Glu Thr Leu Glu His Leu His Ala His Gln Glu Gln Thr Glu
                645                 650                 655     
Glu Leu His Leu Ala Thr Ser Thr Ser Asp Pro Ala Gln His Leu Gln
            660                 665                 670         
Leu Thr Gln Glu Pro Gly Pro Pro Pro Pro Thr His His Val Pro Gln
        675                 680                 685             
Pro Thr Pro Leu Gly Gln Glu Gln Ser
    690                 695         


<210> 2257
<211> 944
<212> PRT
<213> Homo sapiens

<400> 2257
Met Ala Leu Leu Gly Lys Arg Cys Asp Val Pro Thr Asn Gly Cys Gly
 1               5                  10                  15      
Pro Asp Arg Trp Asn Ser Ala Phe Thr Arg Lys Asp Glu Ile Ile Thr
            20                  25                  30          
Ser Leu Val Ser Ala Leu Asp Ser Met Cys Ser Ala Leu Ser Lys Leu
        35                  40                  45              
Asn Ala Glu Val Ala Cys Val Ala Val His Asp Glu Ser Ala Phe Val
    50                  55                  60                  
Val Gly Thr Glu Lys Gly Arg Met Phe Leu Asn Ala Arg Lys Glu Leu
65                  70                  75                  80  
Gln Ser Asp Phe Leu Arg Phe Cys Arg Gly Pro Pro Trp Lys Asp Pro
                85                  90                  95      
Glu Ala Glu His Pro Lys Lys Val Gln Arg Gly Glu Gly Gly Gly Arg
            100                 105                 110         
Ser Leu Pro Arg Ser Ser Leu Glu His Gly Ser Asp Val Tyr Leu Leu
        115                 120                 125             
Arg Lys Met Val Glu Glu Val Phe Asp Val Leu Tyr Ser Glu Ala Leu
    130                 135                 140                 
Gly Arg Ala Ser Val Val Pro Leu Pro Tyr Glu Arg Leu Leu Arg Glu
145                 150                 155                 160 
Pro Gly Leu Leu Ala Val Gln Gly Leu Pro Glu Gly Leu Ala Phe Arg
                165                 170                 175     
Arg Pro Ala Glu Tyr Asp Pro Lys Ala Leu Met Ala Ile Leu Glu His
            180                 185                 190         
Ser His Arg Ile Arg Phe Lys Leu Lys Arg Pro Leu Glu Asp Gly Gly
        195                 200                 205             
Arg Asp Ser Lys Ala Leu Val Glu Leu Asn Gly Val Ser Leu Ile Pro
    210                 215                 220                 
Lys Gly Ser Arg Asp Cys Gly Leu His Gly Gln Ala Pro Lys Val Pro
225                 230                 235                 240 
Pro Gln Asp Leu Pro Pro Thr Ala Thr Ser Ser Ser Met Ala Ser Phe
                245                 250                 255     
Leu Tyr Ser Thr Ala Leu Pro Asn His Ala Ile Arg Glu Leu Lys Gln
            260                 265                 270         
Glu Ala Pro Ser Cys Pro Leu Ala Pro Ser Asp Leu Gly Leu Ser Arg
        275                 280                 285             
Pro Met Pro Glu Pro Lys Ala Thr Gly Ala Gln Asp Phe Ser Asp Cys
    290                 295                 300                 
Cys Gly Gln Lys Pro Thr Gly Pro Gly Gly Pro Leu Ile Gln Asn Val
305                 310                 315                 320 
His Ala Ser Lys Arg Ile Leu Phe Ser Ile Val His Asp Lys Ser Glu
                325                 330                 335     
Lys Trp Asp Ala Phe Ile Lys Glu Thr Glu Asp Ile Asn Thr Leu Arg
            340                 345                 350         
Glu Cys Val Gln Ile Leu Phe Asn Ser Arg Tyr Ala Glu Ala Leu Gly
        355                 360                 365             
Leu Asp His Met Val Pro Val Pro Tyr Arg Lys Ile Ala Cys Asp Pro
    370                 375                 380                 
Glu Ala Val Glu Ile Val Gly Ile Pro Asp Lys Ile Pro Phe Lys Arg
385                 390                 395                 400 
Pro Cys Thr Tyr Gly Val Pro Lys Leu Lys Arg Ile Leu Glu Glu Arg
                405                 410                 415     
His Ser Ile His Phe Ile Ile Lys Arg Met Phe Asp Glu Arg Ile Phe
            420                 425                 430         
Thr Gly Asn Lys Phe Thr Lys Asp Thr Thr Lys Leu Glu Pro Ala Ser
        435                 440                 445             
Pro Pro Glu Asp Thr Ser Ala Glu Val Ser Arg Ala Thr Val Leu Asp
    450                 455                 460                 
Leu Ala Gly Asn Ala Arg Ser Asp Lys Gly Ser Met Ser Glu Asp Cys
465                 470                 475                 480 
Gly Pro Gly Thr Ser Gly Glu Leu Gly Gly Leu Arg Pro Ile Lys Ile
                485                 490                 495     
Glu Pro Glu Asp Leu Asp Ile Ile Gln Val Thr Val Pro Asp Pro Ser
            500                 505                 510         
Pro Thr Ser Glu Glu Met Thr Asp Ser Met Pro Gly His Leu Pro Ser
        515                 520                 525             
Glu Asp Ser Gly Tyr Gly Met Glu Met Leu Thr Asp Lys Gly Leu Ser
    530                 535                 540                 
Glu Asp Ala Arg Pro Glu Glu Arg Pro Val Glu Asp Ser His Gly Asp
545                 550                 555                 560 
Val Ile Arg Pro Leu Arg Lys Gln Val Glu Leu Leu Phe Asn Thr Arg
                565                 570                 575     
Tyr Ala Lys Ala Ile Gly Ile Ser Glu Pro Val Lys Val Pro Tyr Ser
            580                 585                 590         
Lys Phe Leu Met His Pro Glu Glu Leu Phe Val Val Gly Leu Pro Glu
        595                 600                 605             
Gly Ile Ser Leu Arg Arg Pro Asn Cys Phe Gly Ile Ala Lys Leu Arg
    610                 615                 620                 
Lys Ile Leu Glu Ala Ser Asn Ser Ile Gln Phe Val Ile Lys Arg Pro
625                 630                 635                 640 
Glu Leu Leu Thr Glu Gly Val Lys Glu Pro Ile Met Asp Ser Gln Glu
                645                 650                 655     
Arg Asp Ser Gly Asp Pro Leu Val Asp Glu Ser Leu Lys Arg Gln Gly
            660                 665                 670         
Phe Gln Glu Asn Tyr Asp Ala Arg Leu Ser Arg Ile Asp Ile Ala Asn
        675                 680                 685             
Thr Leu Arg Glu Gln Val Gln Asp Leu Phe Asn Lys Lys Tyr Gly Glu
    690                 695                 700                 
Ala Leu Gly Ile Lys Tyr Pro Val Gln Val Pro Tyr Lys Arg Ile Lys
705                 710                 715                 720 
Ser Asn Pro Gly Ser Val Ile Ile Glu Gly Leu Pro Pro Gly Ile Pro
                725                 730                 735     
Phe Arg Lys Pro Cys Thr Phe Gly Ser Gln Asn Leu Glu Arg Ile Leu
            740                 745                 750         
Ala Val Ala Asp Lys Ile Lys Phe Thr Val Thr Arg Pro Phe Gln Gly
        755                 760                 765             
Leu Ile Pro Lys Pro Asp Glu Asp Asp Ala Asn Arg Leu Gly Glu Lys
    770                 775                 780                 
Val Ile Leu Arg Glu Gln Val Lys Glu Leu Phe Asn Glu Lys Tyr Gly
785                 790                 795                 800 
Glu Ala Leu Gly Leu Asn Arg Pro Val Leu Val Pro Tyr Lys Leu Ile
                805                 810                 815     
Arg Asp Ser Pro Asp Ala Val Glu Val Thr Gly Leu Pro Asp Asp Ile
            820                 825                 830         
Pro Phe Arg Asn Pro Asn Thr Tyr Asp Ile His Arg Leu Glu Lys Ile
        835                 840                 845             
Leu Lys Ala Arg Glu His Val Arg Met Val Ile Ile Asn Gln Leu Gln
    850                 855                 860                 
Pro Phe Ala Glu Ile Cys Asn Asp Ala Lys Val Pro Ala Lys Asp Ser
865                 870                 875                 880 
Ser Ile Pro Lys Arg Lys Arg Lys Arg Val Ser Glu Gly Asn Ser Val
                885                 890                 895     
Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Asn Pro Asp Ser
            900                 905                 910         
Val Ala Ser Ala Asn Gln Ile Ser Leu Val Gln Trp Pro Met Tyr Met
        915                 920                 925             
Val Asp Tyr Ala Gly Leu Asn Val Gln Leu Pro Gly Pro Leu Asn Tyr
    930                 935                 940                 


<210> 2258
<211> 338
<212> PRT
<213> Homo sapiens

<400> 2258
Met Leu Ser Ala Leu Ala Arg Pro Ala Ser Ala Ala Leu Arg Arg Ser
 1               5                  10                  15      
Phe Ser Thr Ser Ala Gln Asn Asn Ala Lys Val Ala Val Leu Gly Ala
            20                  25                  30          
Ser Gly Gly Ile Gly Gln Pro Leu Ser Leu Leu Leu Lys Asn Ser Pro
        35                  40                  45              
Leu Val Ser Arg Leu Thr Leu Tyr Asp Ile Ala His Thr Pro Gly Val
    50                  55                  60                  
Ala Ala Asp Leu Ser His Ile Glu Thr Lys Ala Ala Val Lys Gly Tyr
65                  70                  75                  80  
Leu Gly Pro Glu Gln Leu Pro Asp Cys Leu Lys Gly Cys Asp Val Val
                85                  90                  95      
Val Ile Pro Ala Gly Val Pro Arg Lys Pro Gly Met Thr Arg Asp Asp
            100                 105                 110         
Leu Phe Asn Thr Asn Ala Thr Ile Val Ala Thr Leu Thr Ala Ala Cys
        115                 120                 125             
Ala Gln His Cys Pro Glu Ala Met Ile Cys Val Ile Ala Asn Pro Val
    130                 135                 140                 
Asn Ser Thr Ile Pro Ile Thr Ala Glu Val Phe Lys Lys His Gly Val
145                 150                 155                 160 
Tyr Asn Pro Asn Lys Ile Phe Gly Val Thr Thr Leu Asp Ile Val Arg
                165                 170                 175     
Ala Asn Thr Phe Val Ala Glu Leu Lys Gly Leu Asp Pro Ala Arg Val
            180                 185                 190         
Asn Val Pro Val Ile Gly Gly His Ala Gly Lys Thr Ile Ile Pro Leu
        195                 200                 205             
Ile Ser Gln Cys Thr Pro Lys Val Asp Phe Pro Gln Asp Gln Leu Thr
    210                 215                 220                 
Ala Leu Thr Gly Arg Ile Gln Glu Ala Gly Thr Glu Val Val Lys Ala
225                 230                 235                 240 
Lys Ala Gly Ala Gly Ser Ala Thr Leu Ser Met Ala Tyr Ala Gly Ala
                245                 250                 255     
Arg Phe Val Phe Ser Leu Val Asp Ala Met Asn Gly Lys Glu Gly Val
            260                 265                 270         
Val Glu Cys Ser Phe Val Lys Ser Gln Glu Thr Glu Cys Thr Tyr Phe
        275                 280                 285             
Ser Thr Pro Leu Leu Leu Gly Lys Lys Gly Ile Glu Lys Asn Leu Gly
    290                 295                 300                 
Ile Gly Lys Val Ser Ser Phe Glu Glu Lys Met Ile Ser Asp Ala Ile
305                 310                 315                 320 
Pro Glu Leu Lys Ala Ser Ile Lys Lys Gly Glu Asp Phe Val Lys Thr
                325                 330                 335     
Leu Lys
        


<210> 2259
<211> 1039
<212> PRT
<213> Homo sapiens

<400> 2259
Met Glu Pro Asn Asp Ser Thr Ser Thr Ala Val Glu Glu Pro Asp Ser
 1               5                  10                  15      
Leu Glu Val Leu Val Lys Thr Leu Asp Ser Gln Thr Arg Thr Phe Ile
            20                  25                  30          
Val Gly Ala Gln Met Asn Val Lys Glu Phe Lys Glu His Ile Ala Ala
        35                  40                  45              
Ser Val Ser Ile Pro Ser Glu Lys Gln Arg Leu Ile Tyr Gln Gly Arg
    50                  55                  60                  
Val Leu Gln Asp Asp Lys Lys Leu Gln Glu Tyr Asn Val Gly Gly Lys
65                  70                  75                  80  
Val Ile His Leu Val Glu Arg Ala Pro Pro Gln Thr His Leu Pro Ser
                85                  90                  95      
Gly Ala Ser Ser Gly Thr Gly Ser Ala Ser Ala Thr His Gly Gly Gly
            100                 105                 110         
Ser Pro Pro Gly Thr Arg Gly Pro Gly Ala Ser Val His Asp Arg Asn
        115                 120                 125             
Ala Asn Ser Tyr Val Met Val Gly Thr Phe Asn Leu Pro Ser Asp Gly
    130                 135                 140                 
Ser Ala Val Asp Val His Ile Asn Met Glu Gln Ala Pro Ile Gln Ser
145                 150                 155                 160 
Glu Pro Arg Val Arg Leu Val Met Ala Gln His Met Ile Arg Asp Ile
                165                 170                 175     
Gln Thr Leu Leu Ser Arg Met Glu Thr Leu Pro Tyr Leu Gln Cys Arg
            180                 185                 190         
Gly Gly Pro Gln Pro Gln His Ser Gln Pro Pro Pro Gln Pro Pro Ala
        195                 200                 205             
Val Thr Pro Glu Pro Val Ala Leu Ser Ser Gln Thr Ser Glu Pro Val
    210                 215                 220                 
Glu Ser Glu Ala Pro Pro Arg Glu Pro Met Glu Ala Glu Glu Val Glu
225                 230                 235                 240 
Glu Arg Ala Pro Ala Gln Asn Pro Glu Leu Thr Pro Gly Pro Ala Pro
                245                 250                 255     
Ala Gly Pro Thr Pro Ala Pro Glu Thr Asn Ala Pro Asn His Pro Ser
            260                 265                 270         
Pro Ala Glu Tyr Val Glu Val Leu Gln Glu Leu Gln Arg Leu Glu Ser
        275                 280                 285             
Arg Leu Gln Pro Phe Leu Gln Arg Tyr Tyr Glu Val Leu Gly Ala Ala
    290                 295                 300                 
Ala Thr Thr Asp Tyr Asn Asn Asn His Glu Gly Arg Glu Glu Asp Gln
305                 310                 315                 320 
Arg Leu Ile Asn Leu Val Gly Glu Ser Leu Arg Leu Leu Gly Asn Thr
                325                 330                 335     
Phe Val Ala Leu Ser Asp Leu Arg Cys Asn Leu Ala Cys Thr Pro Pro
            340                 345                 350         
Arg His Leu His Val Val Arg Pro Met Ser His Tyr Thr Thr Pro Met
        355                 360                 365             
Val Leu Gln Gln Ala Ala Ile Pro Ile Gln Ile Asn Val Gly Thr Thr
    370                 375                 380                 
Val Thr Met Thr Gly Asn Gly Thr Arg Pro Pro Pro Thr Pro Asn Ala
385                 390                 395                 400 
Glu Ala Pro Pro Pro Gly Pro Gly Gln Ala Ser Ser Val Ala Pro Ser
                405                 410                 415     
Ser Thr Asn Val Glu Ser Ser Ala Glu Gly Ala Pro Pro Pro Gly Pro
            420                 425                 430         
Ala Pro Pro Pro Ala Thr Ser His Pro Arg Val Ile Arg Ile Ser His
        435                 440                 445             
Gln Ser Val Glu Pro Val Val Met Met His Met Asn Ile Gln Asp Ser
    450                 455                 460                 
Gly Thr Gln Pro Gly Gly Val Pro Ser Ala Pro Thr Gly Pro Leu Gly
465                 470                 475                 480 
Pro Pro Gly His Gly Gln Thr Leu Gly Gln Gln Val Pro Gly Phe Pro
                485                 490                 495     
Thr Ala Pro Thr Arg Val Val Ile Ala Arg Pro Thr Pro Pro Gln Ala
            500                 505                 510         
Arg Pro Ser His Pro Gly Gly Pro Pro Val Ser Gly Thr Leu Gln Gly
        515                 520                 525             
Ala Gly Leu Gly Thr Asn Ala Ser Leu Ala Gln Met Val Ser Gly Leu
    530                 535                 540                 
Val Gly Gln Leu Leu Met Gln Pro Val Leu Val Ala Gln Gly Thr Pro
545                 550                 555                 560 
Gly Met Ala Pro Pro Pro Ala Pro Ala Thr Ala Ser Ala Ser Ala Gly
                565                 570                 575     
Thr Thr Asn Thr Ala Thr Thr Ala Gly Pro Ala Pro Gly Gly Pro Ala
            580                 585                 590         
Gln Pro Pro Pro Thr Pro Gln Pro Ser Met Ala Asp Leu Gln Phe Ser
        595                 600                 605             
Gln Leu Leu Gly Asn Leu Leu Gly Pro Ala Gly Pro Gly Ala Gly Gly
    610                 615                 620                 
Ser Gly Val Ala Ser Pro Thr Ile Thr Val Ala Met Pro Gly Val Pro
625                 630                 635                 640 
Ala Phe Leu Gln Gly Met Thr Asp Phe Leu Gln Ala Thr Gln Thr Ala
                645                 650                 655     
Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala Pro Glu Gln
            660                 665                 670         
Gln Thr Met Pro Pro Pro Gly Ser Pro Ser Gly Gly Ala Gly Ser Pro
        675                 680                 685             
Gly Gly Leu Gly Leu Glu Ser Leu Ser Pro Glu Phe Phe Thr Ser Val
    690                 695                 700                 
Val Gln Gly Val Leu Ser Ser Leu Leu Gly Ser Leu Gly Ala Arg Ala
705                 710                 715                 720 
Gly Ser Ser Glu Ser Ile Ala Ala Phe Ile Gln Arg Leu Ser Gly Ser
                725                 730                 735     
Ser Asn Ile Phe Glu Pro Gly Ala Asp Gly Ala Leu Gly Phe Phe Gly
            740                 745                 750         
Ala Leu Leu Ser Leu Leu Cys Gln Asn Phe Ser Met Val Asp Val Val
        755                 760                 765             
Met Leu Leu His Gly His Phe Gln Pro Leu Gln Arg Leu Gln Pro Gln
    770                 775                 780                 
Leu Arg Ser Phe Phe His Gln His Tyr Leu Gly Gly Gln Glu Pro Thr
785                 790                 795                 800 
Pro Ser Asn Ile Arg Met Ala Thr His Thr Leu Ile Thr Gly Leu Glu
                805                 810                 815     
Glu Tyr Val Arg Glu Ser Phe Ser Leu Val Gln Val Gln Pro Gly Val
            820                 825                 830         
Asp Ile Ile Arg Thr Asn Leu Glu Phe Leu Gln Glu Gln Phe Asn Ser
        835                 840                 845             
Ile Ala Ala His Val Leu His Cys Thr Asp Ser Gly Phe Gly Ala Arg
    850                 855                 860                 
Leu Leu Glu Leu Cys Asn Gln Gly Leu Phe Glu Cys Leu Ala Leu Asn
865                 870                 875                 880 
Leu His Cys Leu Gly Gly Gln Gln Met Glu Leu Ala Ala Val Ile Asn
                885                 890                 895     
Gly Arg Ile Arg Arg Met Ser Arg Gly Val Asn Pro Ser Leu Val Ser
            900                 905                 910         
Trp Leu Thr Thr Met Met Gly Leu Arg Leu Gln Val Val Leu Glu His
        915                 920                 925             
Met Pro Val Gly Pro Asp Ala Ile Leu Arg Tyr Val Arg Arg Val Gly
    930                 935                 940                 
Asp Pro Pro Gln Pro Leu Pro Glu Glu Pro Met Glu Val Gln Gly Ala
945                 950                 955                 960 
Glu Arg Ala Ser Pro Glu Pro Gln Arg Glu Asn Ala Ser Pro Ala Pro
                965                 970                 975     
Gly Thr Thr Ala Glu Glu Ala Met Ser Arg Gly Pro Pro Pro Ala Pro
            980                 985                 990         
Glu Gly Gly Ser Arg Asp Glu Gln Asp Gly Ala Ser Ala Glu Thr Glu
        995                 1000                1005            
Pro Trp Ala Ala Ala Val Pro Pro Gly Met Gly Pro Tyr Tyr Pro Ala
    1010                1015                1020                
Gly His Ser Glu Pro Ala Glu Gly Glu Thr Ala Ala Pro Ser Glu
1025                1030                1035                


<210> 2260
<211> 886
<212> PRT
<213> Homo sapiens

<400> 2260
Met Arg Arg Arg Ala Met Ser His Asn Val Lys Arg Leu Pro Arg Arg
 1               5                  10                  15      
Leu Gln Glu Ile Ala Gln Lys Glu Ala Glu Lys Ala Val His Gln Lys
            20                  25                  30          
Lys Glu His Ser Lys Asn Lys Cys His Lys Ala Arg Arg Cys His Met
        35                  40                  45              
Asn Arg Thr Leu Glu Phe Asn Arg Arg Gln Lys Lys Asn Ile Trp Leu
    50                  55                  60                  
Glu Thr His Ile Trp His Ala Lys Arg Phe His Met Val Lys Lys Trp
65                  70                  75                  80  
Gly Tyr Cys Leu Gly Glu Arg Pro Thr Val Lys Ser His Arg Ala Cys
                85                  90                  95      
Tyr Arg Ala Met Thr Asn Arg Cys Leu Leu Gln Asp Leu Ser Tyr Tyr
            100                 105                 110         
Cys Cys Leu Glu Leu Lys Gly Lys Glu Glu Glu Ile Leu Lys Ala Leu
        115                 120                 125             
Ser Gly Met Cys Asn Ile Asp Thr Gly Leu Thr Phe Ala Ala Val His
    130                 135                 140                 
Cys Leu Ser Gly Lys Arg Gln Gly Ser Leu Val Leu Tyr Arg Val Asn
145                 150                 155                 160 
Lys Tyr Pro Arg Glu Met Leu Gly Pro Val Thr Phe Ile Trp Lys Ser
                165                 170                 175     
Gln Arg Thr Pro Gly Asp Pro Ser Glu Ser Arg Gln Leu Trp Ile Trp
            180                 185                 190         
Leu His Pro Thr Leu Lys Gln Asp Ile Leu Glu Glu Ile Lys Ala Ala
        195                 200                 205             
Cys Gln Cys Val Glu Pro Ile Lys Ser Ala Val Cys Ile Ala Asp Pro
    210                 215                 220                 
Leu Pro Thr Pro Ser Gln Glu Lys Ser Gln Thr Glu Leu Pro Asp Glu
225                 230                 235                 240 
Lys Ile Gly Lys Lys Arg Lys Arg Lys Asp Asp Gly Glu Asn Ala Lys
                245                 250                 255     
Pro Ile Lys Lys Ile Ile Gly Asp Gly Thr Arg Asp Pro Cys Leu Pro
            260                 265                 270         
Tyr Ser Trp Ile Ser Pro Thr Thr Gly Ile Ile Ile Ser Asp Leu Thr
        275                 280                 285             
Met Glu Met Asn Arg Phe Arg Leu Ile Gly Pro Leu Ser His Ser Ile
    290                 295                 300                 
Leu Thr Glu Ala Ile Lys Ala Ala Ser Val His Thr Val Gly Glu Asp
305                 310                 315                 320 
Thr Glu Glu Thr Pro His Arg Trp Trp Ile Glu Thr Cys Lys Lys Pro
                325                 330                 335     
Asp Ser Val Ser Leu His Cys Arg Gln Glu Ala Ile Phe Glu Leu Leu
            340                 345                 350         
Gly Gly Ile Thr Ser Pro Ala Glu Ile Pro Ala Gly Thr Ile Leu Gly
        355                 360                 365             
Leu Thr Val Gly Asp Pro Arg Ile Asn Leu Pro Gln Lys Lys Ser Lys
    370                 375                 380                 
Ala Leu Pro Asn Pro Glu Lys Cys Gln Asp Asn Glu Lys Val Arg Gln
385                 390                 395                 400 
Leu Leu Leu Glu Gly Val Pro Val Glu Cys Thr His Ser Phe Ile Trp
                405                 410                 415     
Asn Gln Asp Ile Cys Lys Ser Val Thr Glu Asn Lys Ile Ser Asp Gln
            420                 425                 430         
Asp Leu Asn Arg Met Arg Ser Glu Leu Leu Val Pro Gly Ser Gln Leu
        435                 440                 445             
Ile Leu Gly Pro His Glu Ser Lys Ile Pro Ile Leu Leu Ile Gln Gln
    450                 455                 460                 
Pro Gly Lys Val Thr Gly Glu Asp Arg Leu Gly Trp Gly Ser Gly Trp
465                 470                 475                 480 
Asp Val Leu Leu Pro Lys Gly Trp Gly Met Ala Phe Trp Ile Pro Phe
                485                 490                 495     
Ile Tyr Arg Gly Val Arg Val Gly Gly Leu Lys Glu Ser Ala Val His
            500                 505                 510         
Ser Gln Tyr Lys Arg Ser Pro Asn Val Pro Gly Asp Phe Pro Asp Cys
        515                 520                 525             
Pro Ala Gly Met Leu Phe Ala Glu Glu Gln Ala Lys Asn Leu Leu Glu
    530                 535                 540                 
Lys Tyr Lys Arg Arg Pro Pro Ala Lys Arg Pro Asn Tyr Val Lys Leu
545                 550                 555                 560 
Gly Thr Leu Ala Pro Phe Cys Cys Pro Trp Glu Gln Leu Thr Gln Asp
                565                 570                 575     
Trp Glu Ser Arg Val Gln Ala Tyr Glu Glu Pro Ser Val Ala Ser Ser
            580                 585                 590         
Pro Asn Gly Lys Glu Ser Asp Leu Arg Arg Ser Glu Val Pro Cys Ala
        595                 600                 605             
Pro Met Pro Lys Lys Thr His Gln Pro Ser Asp Glu Val Gly Thr Ser
    610                 615                 620                 
Ile Glu His Pro Arg Glu Ala Glu Glu Val Met Asp Ala Gly Cys Gln
625                 630                 635                 640 
Glu Ser Ala Gly Pro Glu Arg Ile Thr Asp Gln Glu Ala Ser Glu Asn
                645                 650                 655     
His Val Ala Ala Thr Gly Ser His Leu Cys Val Leu Arg Ser Arg Lys
            660                 665                 670         
Leu Leu Lys Gln Leu Ser Ala Trp Cys Gly Pro Ser Ser Glu Asp Ser
        675                 680                 685             
Arg Gly Gly Arg Arg Ala Pro Gly Arg Gly Gln Gln Gly Leu Thr Arg
    690                 695                 700                 
Glu Ala Cys Leu Ser Ile Leu Gly His Phe Pro Arg Ala Leu Val Trp
705                 710                 715                 720 
Val Ser Leu Ser Leu Leu Ser Lys Gly Ser Pro Glu Pro His Thr Met
                725                 730                 735     
Ile Cys Val Pro Ala Lys Glu Asp Phe Leu Gln Leu His Glu Asp Trp
            740                 745                 750         
His Tyr Cys Gly Pro Gln Glu Ser Lys His Ser Asp Pro Phe Arg Ser
        755                 760                 765             
Lys Ile Leu Lys Gln Lys Glu Lys Lys Lys Arg Glu Lys Arg Gln Lys
    770                 775                 780                 
Pro Gly Arg Ala Ser Ser Asp Gly Pro Ala Gly Glu Glu Pro Val Ala
785                 790                 795                 800 
Gly Gln Glu Ala Leu Thr Leu Gly Leu Trp Ser Gly Pro Leu Pro Arg
                805                 810                 815     
Val Thr Leu His Cys Ser Arg Thr Leu Leu Gly Phe Val Thr Gln Gly
            820                 825                 830         
Asp Phe Ser Met Ala Val Gly Cys Gly Glu Ala Leu Gly Phe Val Ser
        835                 840                 845             
Leu Thr Gly Leu Leu Asp Met Leu Ser Ser Gln Pro Ala Ala Gln Arg
    850                 855                 860                 
Gly Leu Val Leu Leu Arg Pro Pro Ala Ser Leu Gln Tyr Arg Phe Ala
865                 870                 875                 880 
Arg Ile Ala Ile Glu Val
                885     


<210> 2261
<211> 444
<212> PRT
<213> Homo sapiens

<400> 2261
Met Ser Ser Ser Tyr Asp Glu Ala Ser Leu Ala Pro Glu Glu Thr Thr
 1               5                  10                  15      
Asp Ser Phe Trp Glu Val Gly Asn Tyr Lys Arg Thr Val Lys Arg Ile
            20                  25                  30          
Asp Asp Gly His Arg Leu Cys Asn Asp Leu Met Asn Cys Val Gln Glu
        35                  40                  45              
Arg Ala Lys Ile Glu Lys Ala Tyr Gly Gln Gln Leu Thr Asp Trp Ala
    50                  55                  60                  
Lys Arg Trp Arg Gln Leu Ile Glu Lys Gly Pro Gln Tyr Gly Ser Leu
65                  70                  75                  80  
Glu Arg Ala Trp Gly Ala Ile Met Thr Glu Ala Asp Lys Val Ser Glu
                85                  90                  95      
Leu His Gln Glu Val Lys Asn Asn Leu Leu Asn Glu Asp Leu Glu Lys
            100                 105                 110         
Val Lys Asn Trp Gln Lys Asp Ala Tyr His Lys Gln Ile Met Gly Gly
        115                 120                 125             
Phe Lys Glu Thr Lys Glu Ala Glu Asp Gly Phe Arg Lys Ala Gln Lys
    130                 135                 140                 
Pro Trp Ala Lys Lys Met Lys Glu Leu Glu Ala Ala Lys Lys Ala Tyr
145                 150                 155                 160 
His Leu Ala Cys Lys Glu Glu Lys Leu Ala Met Thr Arg Glu Met Asn
                165                 170                 175     
Ser Lys Thr Glu Gln Ser Val Thr Pro Glu Gln Gln Lys Lys Leu Gln
            180                 185                 190         
Asp Lys Val Asp Lys Cys Lys Gln Asp Val Gln Lys Thr Gln Glu Lys
        195                 200                 205             
Tyr Glu Lys Val Leu Glu Asp Val Gly Lys Thr Thr Pro Gln Tyr Met
    210                 215                 220                 
Glu Asn Met Glu Gln Val Phe Glu Gln Cys Gln Gln Phe Glu Glu Lys
225                 230                 235                 240 
Arg Leu Val Phe Leu Lys Glu Val Leu Leu Asp Ile Lys Arg His Leu
                245                 250                 255     
Asn Leu Ala Glu Asn Ser Ser Tyr Ile His Val Tyr Arg Glu Leu Glu
            260                 265                 270         
Gln Ala Ile Arg Gly Ala Asp Ala Gln Glu Asp Leu Arg Trp Phe Arg
        275                 280                 285             
Ser Thr Ser Gly Pro Gly Met Pro Met Asn Trp Pro Gln Phe Glu Glu
    290                 295                 300                 
Trp Asn Pro Asp Leu Pro His Thr Thr Thr Lys Lys Glu Lys Gln Pro
305                 310                 315                 320 
Lys Lys Ala Glu Gly Val Ala Leu Thr Asn Ala Thr Gly Ala Val Glu
                325                 330                 335     
Ser Thr Ser Gln Ala Gly Asp Arg Gly Ser Val Ser Ser Tyr Asp Arg
            340                 345                 350         
Gly Gln Pro Tyr Ala Thr Glu Trp Ser Asp Asp Glu Ser Gly Asn Pro
        355                 360                 365             
Phe Gly Gly Ser Glu Thr Asn Gly Gly Ala Asn Pro Phe Glu Asp Asp
    370                 375                 380                 
Ser Lys Gly Val Arg Val Arg Ala Leu Tyr Asp Tyr Asp Gly Gln Glu
385                 390                 395                 400 
Gln Asp Glu Leu Ser Phe Lys Ala Gly Asp Glu Leu Thr Lys Leu Gly
                405                 410                 415     
Glu Glu Asp Glu Gln Gly Trp Cys Arg Gly Arg Leu Asp Ser Gly Gln
            420                 425                 430         
Leu Gly Leu Tyr Pro Ala Asn Tyr Val Glu Ala Ile
        435                 440                 


<210> 2262
<211> 542
<212> PRT
<213> Homo sapiens

<400> 2262
Met Pro Leu Arg Asp Glu Thr Leu Arg Glu Val Trp Ala Ser Asp Ser
 1               5                  10                  15      
Gly His Glu Glu Glu Ser Leu Ser Pro Glu Ala Pro Arg Arg Pro Lys
            20                  25                  30          
Gln Arg Pro Ala Pro Ala Gln Arg Leu Arg Lys Lys Arg Thr Glu Ala
        35                  40                  45              
Pro Glu Ser Pro Cys Pro Thr Gly Ser Lys Pro Arg Lys Pro Gly Ala
    50                  55                  60                  
Gly Arg Thr Gly Arg Pro Arg Glu Glu Pro Ser Pro Asp Pro Ala Gln
65                  70                  75                  80  
Ala Arg Ala Pro Gln Thr Val Tyr Ala Arg Phe Leu Arg Asp Pro Glu
                85                  90                  95      
Ala Lys Lys Arg Asp Pro Arg Glu Thr Phe Leu Val Ala Arg Ala Pro
            100                 105                 110         
Asp Ala Glu Asp Glu Glu Glu Glu Glu Glu Glu Asp Glu Glu Asp Glu
        115                 120                 125             
Glu Glu Glu Ala Glu Glu Lys Lys Glu Lys Ile Leu Leu Pro Pro Lys
    130                 135                 140                 
Lys Pro Leu Arg Glu Lys Ser Ser Ala Asp Leu Lys Glu Arg Arg Ala
145                 150                 155                 160 
Lys Ala Gln Gly Pro Arg Gly Asp Leu Gly Ser Pro Asp Pro Pro Pro
                165                 170                 175     
Lys Pro Leu Arg Val Arg Asn Lys Glu Ala Pro Ala Gly Glu Gly Thr
            180                 185                 190         
Lys Met Arg Lys Thr Lys Lys Lys Gly Ser Gly Glu Ala Asp Lys Asp
        195                 200                 205             
Pro Ser Gly Ser Pro Ala Ser Ala Arg Lys Ser Pro Ala Ala Met Phe
    210                 215                 220                 
Leu Val Gly Glu Gly Ser Pro Asp Lys Lys Ala Leu Lys Lys Lys Gly
225                 230                 235                 240 
Thr Pro Lys Gly Ala Arg Lys Glu Glu Glu Glu Glu Glu Glu Ala Ala
                245                 250                 255     
Thr Val Ile Lys Lys Ser Asn Gln Lys Gly Lys Ala Lys Gly Lys Gly
            260                 265                 270         
Lys Lys Val Gly Lys Glu Glu Arg Ala Pro Ser Pro Pro Val Glu Val
        275                 280                 285             
Asp Glu Pro Arg Glu Phe Val Leu Arg Pro Ala Pro Gln Gly Arg Thr
    290                 295                 300                 
Val Arg Cys Arg Leu Thr Arg Asp Lys Lys Gly Met Asp Arg Gly Met
305                 310                 315                 320 
Tyr Pro Ser Tyr Phe Leu His Leu Asp Thr Glu Lys Lys Val Phe Leu
                325                 330                 335     
Leu Ala Gly Arg Lys Arg Lys Arg Ser Lys Thr Ala Asn Tyr Leu Ile
            340                 345                 350         
Ser Ile Asp Pro Thr Asn Leu Ser Arg Gly Gly Glu Asn Phe Ile Gly
        355                 360                 365             
Lys Leu Arg Ser Asn Leu Leu Gly Asn Arg Phe Thr Val Phe Asp Asn
    370                 375                 380                 
Gly Gln Asn Pro Gln Arg Gly Tyr Ser Thr Asn Val Ala Ser Leu Arg
385                 390                 395                 400 
Gln Glu Leu Ala Ala Val Ile Tyr Glu Thr Asn Val Leu Gly Phe Arg
                405                 410                 415     
Gly Pro Arg Arg Met Thr Val Ile Ile Pro Gly Met Ser Ala Glu Asn
            420                 425                 430         
Glu Arg Val Pro Ile Arg Pro Arg Asn Ala Ser Asp Gly Leu Leu Val
        435                 440                 445             
Arg Trp Gln Asn Lys Thr Leu Glu Ser Leu Ile Glu Leu His Asn Lys
    450                 455                 460                 
Pro Pro Val Trp Asn Asp Asp Ser Gly Ser Tyr Thr Leu Asn Phe Gln
465                 470                 475                 480 
Gly Arg Val Thr Gln Ala Ser Val Lys Asn Phe Gln Ile Val His Ala
                485                 490                 495     
Asp Asp Pro Asp Tyr Ile Val Leu Gln Phe Gly Arg Val Ala Glu Asp
            500                 505                 510         
Ala Phe Thr Leu Asp Tyr Arg Tyr Pro Leu Cys Ala Leu Gln Ala Phe
        515                 520                 525             
Ala Ile Ala Leu Ser Ser Phe Asp Gly Lys Leu Ala Cys Glu
    530                 535                 540         


<210> 2263
<211> 367
<212> PRT
<213> Homo sapiens

<400> 2263
Met Ser Leu Ile Arg Lys Lys Gly Phe Tyr Lys Gln Asp Val Asn Lys
 1               5                  10                  15      
Thr Ala Trp Glu Leu Pro Lys Thr Tyr Val Ser Pro Thr His Val Gly
            20                  25                  30          
Ser Gly Ala Tyr Gly Ser Val Cys Ser Ala Ile Asp Lys Arg Ser Gly
        35                  40                  45              
Glu Lys Val Ala Ile Lys Lys Leu Ser Arg Pro Phe Gln Ser Glu Ile
    50                  55                  60                  
Phe Ala Lys Arg Ala Tyr Arg Glu Leu Leu Leu Leu Lys His Met Gln
65                  70                  75                  80  
His Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Ala Ser Ser
                85                  90                  95      
Leu Arg Asn Phe Tyr Asp Phe Tyr Leu Val Met Pro Phe Met Gln Thr
            100                 105                 110         
Asp Leu Gln Lys Ile Met Gly Met Glu Phe Ser Glu Glu Lys Ile Gln
        115                 120                 125             
Tyr Leu Val Tyr Gln Met Leu Lys Gly Leu Lys Tyr Ile His Ser Ala
    130                 135                 140                 
Gly Val Val His Arg Asp Leu Lys Pro Gly Asn Leu Ala Val Asn Glu
145                 150                 155                 160 
Asp Cys Glu Leu Lys Val Lys Ile Leu Asp Phe Gly Leu Ala Arg His
                165                 170                 175     
Ala Asp Ala Glu Met Thr Gly Tyr Val Val Thr Arg Trp Tyr Arg Ala
            180                 185                 190         
Pro Glu Val Ile Leu Ser Trp Met His Tyr Asn Gln Thr Val Asp Ile
        195                 200                 205             
Trp Ser Val Gly Cys Ile Met Ala Glu Met Leu Thr Gly Lys Thr Leu
    210                 215                 220                 
Phe Lys Gly Lys Asp Tyr Leu Asp Gln Leu Thr Gln Ile Leu Lys Val
225                 230                 235                 240 
Thr Gly Val Pro Gly Thr Glu Phe Val Gln Lys Leu Asn Asp Lys Ala
                245                 250                 255     
Ala Lys Ser Tyr Ile Gln Ser Leu Pro Gln Thr Pro Arg Lys Asp Phe
            260                 265                 270         
Thr Gln Leu Phe Pro Arg Ala Ser Pro Gln Ala Ala Asp Leu Leu Glu
        275                 280                 285             
Lys Met Leu Glu Leu Asp Val Asp Lys Arg Leu Thr Ala Ala Gln Ala
    290                 295                 300                 
Leu Thr His Pro Phe Phe Glu Pro Phe Arg Asp Pro Glu Glu Glu Thr
305                 310                 315                 320 
Glu Ala Gln Gln Pro Phe Asp Asp Ser Leu Glu His Glu Lys Leu Thr
                325                 330                 335     
Val Asp Glu Trp Lys Gln His Ile Tyr Lys Glu Ile Val Asn Phe Ser
            340                 345                 350         
Pro Ile Ala Arg Lys Asp Ser Arg Arg Arg Ser Gly Met Lys Leu
        355                 360                 365         


<210> 2264
<211> 474
<212> PRT
<213> Homo sapiens

<400> 2264
Met Ala Asp Gly Gly Phe Ser Val Glu Gly Gln Glu Asn Leu Gln Glu
 1               5                  10                  15      
Ile Leu Ser Lys Gln Leu Leu Leu Cys Gln Phe Leu Met Ala Leu Ser
            20                  25                  30          
Ile Val Arg Thr Gly Gly His Phe Ile Cys Lys Thr Phe Asp Leu Phe
        35                  40                  45              
Thr Pro Phe Ser Val Gly Leu Val Tyr Leu Leu Tyr Cys Cys Phe Glu
    50                  55                  60                  
Arg Val Cys Leu Phe Lys Pro Ile Thr Ser Arg Pro Ala Asn Ser Glu
65                  70                  75                  80  
Arg Tyr Val Val Cys Lys Gly Leu Lys Val Gly Ile Asp Asp Val Arg
                85                  90                  95      
Asp Tyr Leu Phe Ala Val Asn Ile Lys Leu Asn Gln Leu Arg Asn Thr
            100                 105                 110         
Asp Ser Asp Val Asn Leu Val Val Pro Leu Glu Val Ile Lys Gly Asp
        115                 120                 125             
His Glu Phe Thr Asp Tyr Met Ile Arg Ser Asn Glu Ser His Cys Ser
    130                 135                 140                 
Leu Gln Ile Lys Ala Leu Ala Lys Ile His Ala Phe Val Gln Asp Thr
145                 150                 155                 160 
Thr Leu Ser Glu Pro Arg Gln Ala Glu Ile Arg Lys Glu Cys Leu Arg
                165                 170                 175     
Leu Trp Gly Ile Pro Asp Gln Ala Arg Val Ala Pro Ser Ser Ser Asp
            180                 185                 190         
Pro Lys Ser Lys Phe Phe Glu Leu Ile Gln Gly Thr Glu Ile Asp Ile
        195                 200                 205             
Phe Ser Tyr Lys Pro Thr Leu Leu Thr Ser Lys Thr Leu Glu Lys Ile
    210                 215                 220                 
Arg Pro Val Phe Asp Tyr Arg Cys Met Val Ser Gly Ser Glu Gln Lys
225                 230                 235                 240 
Phe Leu Ile Gly Leu Gly Lys Ser Gln Ile Tyr Thr Trp Asp Gly Arg
                245                 250                 255     
Gln Ser Asp Arg Trp Ile Lys Leu Asp Leu Lys Thr Glu Leu Pro Arg
            260                 265                 270         
Asp Thr Leu Leu Ser Val Glu Ile Val His Glu Leu Lys Gly Glu Gly
        275                 280                 285             
Lys Ala Gln Arg Lys Ile Ser Ala Ile His Ile Leu Asp Val Leu Val
    290                 295                 300                 
Leu Asn Gly Thr Asp Val Arg Glu Gln His Phe Asn Gln Arg Ile Gln
305                 310                 315                 320 
Leu Ala Glu Lys Phe Val Lys Ala Val Ser Lys Pro Ser Arg Pro Asp
                325                 330                 335     
Met Asn Pro Ile Arg Val Lys Glu Val Tyr Arg Leu Glu Glu Met Glu
            340                 345                 350         
Lys Ile Phe Val Arg Leu Glu Met Lys Ile Ile Lys Gly Ser Ser Gly
        355                 360                 365             
Thr Pro Lys Leu Ser Tyr Thr Gly Arg Asp Asp Arg His Phe Val Pro
    370                 375                 380                 
Met Gly Leu Tyr Ile Val Arg Thr Val Asn Glu Pro Trp Thr Met Gly
385                 390                 395                 400 
Phe Ser Lys Ser Phe Lys Lys Lys Phe Phe Tyr Asn Lys Lys Thr Lys
                405                 410                 415     
Asp Ser Thr Phe Asp Leu Pro Ala Asp Ser Ile Ala Pro Phe His Ile
            420                 425                 430         
Cys Tyr Tyr Gly Arg Leu Phe Trp Glu Trp Gly Asp Gly Ile Arg Val
        435                 440                 445             
His Asp Ser Gln Lys Pro Gln Asp Gln Asp Lys Leu Ser Lys Glu Asp
    450                 455                 460                 
Val Leu Ser Phe Ile Gln Met His Arg Ala
465                 470                 


<210> 2265
<211> 1788
<212> PRT
<213> Homo sapiens

<400> 2265
Met Lys Arg Lys Glu Arg Ile Ala Arg Arg Leu Glu Gly Ile Glu Asn
 1               5                  10                  15      
Asp Thr Gln Pro Ile Leu Leu Gln Ser Cys Thr Gly Leu Val Thr His
            20                  25                  30          
Arg Leu Leu Glu Glu Asp Thr Pro Arg Tyr Met Arg Ala Ser Asp Pro
        35                  40                  45              
Ala Ser Pro His Ile Gly Arg Ser Asn Glu Glu Glu Glu Thr Ser Asp
    50                  55                  60                  
Ser Ser Leu Glu Lys Gln Thr Arg Ser Lys Tyr Cys Thr Glu Thr Ser
65                  70                  75                  80  
Gly Val His Gly Asp Ser Pro Tyr Gly Ser Gly Thr Met Asp Thr His
                85                  90                  95      
Ser Leu Glu Ser Lys Ala Glu Arg Ile Ala Arg Tyr Lys Ala Glu Arg
            100                 105                 110         
Arg Arg Gln Leu Ala Glu Lys Tyr Gly Leu Thr Leu Asp Pro Glu Ala
        115                 120                 125             
Asp Ser Glu Tyr Leu Ser Arg Tyr Thr Lys Ser Arg Lys Glu Pro Asp
    130                 135                 140                 
Ala Val Glu Lys Arg Gly Gly Lys Ser Asp Lys Gln Glu Glu Ser Ser
145                 150                 155                 160 
Arg Asp Ala Ser Ser Leu Tyr Pro Gly Thr Glu Thr Met Gly Leu Arg
                165                 170                 175     
Thr Cys Ala Gly Glu Ser Lys Asp Tyr Ala Leu His Val Gly Asp Gly
            180                 185                 190         
Ser Ser Asp Pro Glu Val Leu Leu Asn Ile Glu Asn Gln Arg Arg Gly
        195                 200                 205             
Gln Glu Leu Ser Ala Thr Arg Gln Ala His Asp Leu Ser Pro Ala Ala
    210                 215                 220                 
Glu Ser Ser Ser Thr Phe Ser Phe Ser Gly Arg Asp Ser Ser Phe Thr
225                 230                 235                 240 
Glu Val Pro Arg Ser Pro Lys His Ala His Ser Ser Ser Leu Gln Gln
                245                 250                 255     
Ala Ala Ser Arg Ser Pro Ser Phe Gly Asp Pro Gln Leu Ser Pro Glu
            260                 265                 270         
Ala Arg Pro Arg Cys Thr Ser His Ser Glu Thr Pro Thr Val Asp Asp
        275                 280                 285             
Glu Glu Lys Val Asp Glu Arg Ala Lys Leu Ser Val Ala Ala Lys Arg
    290                 295                 300                 
Leu Leu Phe Arg Glu Met Glu Lys Ser Phe Asp Glu Gln Asn Val Pro
305                 310                 315                 320 
Lys Arg Arg Ser Arg Asn Thr Ala Val Glu Gln Arg Leu Arg Arg Leu
                325                 330                 335     
Gln Asp Arg Ser Leu Thr Gln Pro Ile Thr Thr Glu Glu Val Val Ile
            340                 345                 350         
Ala Ala Thr Leu Gln Ala Ser Ala His Gln Lys Ala Leu Ala Lys Asp
        355                 360                 365             
Gln Thr Asn Glu Gly Lys Glu Leu Ala Glu Gln Gly Glu Pro Asp Ser
    370                 375                 380                 
Ser Thr Leu Ser Leu Ala Glu Lys Leu Ala Leu Phe Asn Lys Leu Ser
385                 390                 395                 400 
Gln Pro Val Ser Lys Ala Ile Ser Thr Arg Asn Arg Ile Asp Thr Arg
                405                 410                 415     
Gln Arg Arg Met Asn Ala Arg Tyr Gln Thr Gln Pro Val Thr Leu Gly
            420                 425                 430         
Glu Val Glu Gln Val Gln Ser Gly Lys Leu Ile Pro Phe Ser Pro Ala
        435                 440                 445             
Val Asn Thr Ser Val Ser Thr Val Ala Ser Thr Val Ala Pro Met Tyr
    450                 455                 460                 
Ala Gly Asp Leu Arg Thr Lys Pro Pro Leu Asp His Asn Ala Ser Ala
465                 470                 475                 480 
Thr Asp Tyr Lys Phe Ser Ser Ser Ile Glu Asn Ser Asp Ser Pro Val
                485                 490                 495     
Arg Ser Ile Leu Lys Ser Gln Ala Trp Gln Pro Leu Val Glu Gly Ser
            500                 505                 510         
Glu Asn Lys Gly Met Leu Arg Glu Tyr Gly Glu Thr Glu Ser Lys Arg
        515                 520                 525             
Ala Leu Thr Gly Arg Asp Ser Gly Met Glu Lys Tyr Gly Ser Phe Glu
    530                 535                 540                 
Glu Ala Glu Ala Ser Tyr Pro Ile Leu Asn Arg Ala Arg Glu Gly Asp
545                 550                 555                 560 
Ser His Lys Glu Ser Lys Tyr Ala Val Pro Arg Arg Gly Ser Leu Glu
                565                 570                 575     
Arg Ala Asn Pro Pro Ile Thr His Leu Gly Asp Glu Pro Lys Glu Phe
            580                 585                 590         
Ser Met Ala Lys Met Asn Ala Gln Gly Asn Leu Asp Leu Arg Asp Arg
        595                 600                 605             
Leu Pro Phe Glu Glu Lys Val Glu Val Glu Asn Val Met Lys Arg Lys
    610                 615                 620                 
Phe Ser Leu Arg Ala Ala Glu Phe Gly Glu Pro Thr Ser Glu Gln Thr
625                 630                 635                 640 
Gly Thr Ala Ala Gly Lys Thr Ile Ala Gln Thr Thr Ala Pro Val Ser
                645                 650                 655     
Trp Lys Pro Gln Asp Ser Ser Glu Gln Pro Gln Glu Lys Leu Cys Lys
            660                 665                 670         
Asn Pro Cys Ala Met Phe Ala Ala Gly Glu Ile Lys Thr Pro Thr Gly
        675                 680                 685             
Glu Gly Leu Leu Asp Ser Pro Ser Lys Thr Met Ser Ile Lys Glu Arg
    690                 695                 700                 
Leu Ala Leu Leu Lys Lys Ser Gly Glu Glu Asp Trp Arg Asn Arg Leu
705                 710                 715                 720 
Ser Arg Arg Gln Glu Gly Gly Lys Ala Pro Ala Ser Ser Leu His Thr
                725                 730                 735     
Gln Glu Ala Gly Arg Ser Leu Ile Lys Lys Arg Val Thr Glu Ser Arg
            740                 745                 750         
Glu Ser Gln Met Thr Ile Glu Glu Arg Lys Gln Leu Ile Thr Val Arg
        755                 760                 765             
Glu Glu Ala Trp Lys Thr Arg Gly Arg Gly Ala Ala Asn Asp Ser Thr
    770                 775                 780                 
Gln Phe Thr Val Ala Gly Arg Met Val Lys Lys Gly Leu Ala Ser Pro
785                 790                 795                 800 
Thr Ala Ile Thr Pro Val Ala Ser Pro Ile Cys Gly Lys Thr Arg Gly
                805                 810                 815     
Thr Thr Pro Val Ser Lys Pro Leu Glu Asp Ile Glu Ala Arg Pro Asp
            820                 825                 830         
Met Gln Leu Glu Ser Asp Leu Lys Leu Asp Arg Leu Glu Thr Phe Leu
        835                 840                 845             
Arg Arg Leu Asn Asn Lys Val Gly Gly Met His Glu Thr Val Leu Thr
    850                 855                 860                 
Val Thr Gly Lys Ser Val Lys Glu Val Met Lys Pro Asp Asp Asp Glu
865                 870                 875                 880 
Thr Phe Ala Lys Phe Tyr Arg Ser Val Asp Tyr Asn Met Pro Arg Ser
                885                 890                 895     
Pro Val Glu Met Asp Glu Asp Phe Asp Val Ile Phe Asp Pro Tyr Ala
            900                 905                 910         
Pro Lys Leu Thr Ser Ser Val Ala Glu His Lys Arg Ala Val Arg Pro
        915                 920                 925             
Lys Arg Arg Val Gln Ala Ser Lys Asn Pro Leu Lys Met Leu Ala Ala
    930                 935                 940                 
Arg Glu Asp Leu Leu Gln Glu Tyr Thr Glu Gln Arg Leu Asn Val Ala
945                 950                 955                 960 
Phe Met Glu Ser Lys Arg Met Lys Val Glu Lys Met Ser Ser Asn Ser
                965                 970                 975     
Asn Phe Ser Glu Val Thr Leu Ala Gly Leu Ala Ser Lys Glu Asn Phe
            980                 985                 990         
Ser Asn Val Ser Leu Arg Ser Val Asn Leu Thr Glu Gln Asn Ser Asn
        995                 1000                1005            
Asn Ser Ala Val Pro Tyr Lys Arg Leu Met Leu Leu Gln Ile Lys Gly
    1010                1015                1020                
Arg Arg His Val Gln Thr Arg Leu Val Glu Pro Arg Ala Ser Ala Leu
1025                1030                1035                1040
Asn Ser Gly Asp Cys Phe Leu Leu Leu Ser Pro His Cys Cys Phe Leu
                1045                1050                1055    
Trp Val Gly Glu Phe Ala Asn Val Ile Glu Lys Ala Lys Ala Ser Glu
            1060                1065                1070        
Leu Ala Thr Leu Ile Gln Thr Lys Arg Glu Leu Gly Cys Arg Ala Thr
        1075                1080                1085            
Tyr Ile Gln Thr Ile Glu Glu Gly Ile Asn Thr His Thr His Ala Ala
    1090                1095                1100                
Lys Asp Phe Trp Lys Leu Leu Gly Gly Gln Thr Ser Tyr Gln Ser Ala
1105                1110                1115                1120
Gly Asp Pro Lys Glu Asp Glu Leu Tyr Glu Ala Ala Ile Ile Glu Thr
                1125                1130                1135    
Asn Cys Ile Tyr Arg Leu Met Asp Asp Lys Leu Val Pro Asp Asp Asp
            1140                1145                1150        
Tyr Trp Gly Lys Ile Pro Lys Cys Ser Leu Leu Gln Pro Lys Glu Val
        1155                1160                1165            
Leu Val Phe Asp Phe Gly Ser Glu Val Tyr Val Trp His Gly Lys Glu
    1170                1175                1180                
Val Thr Leu Ala Gln Arg Lys Ile Ala Phe Gln Leu Ala Lys His Leu
1185                1190                1195                1200
Trp Asn Gly Thr Phe Asp Tyr Glu Asn Cys Asp Ile Asn Pro Leu Asp
                1205                1210                1215    
Pro Gly Glu Cys Asn Pro Leu Ile Pro Arg Lys Gly Gln Gly Arg Pro
            1220                1225                1230        
Asp Trp Ala Ile Phe Gly Arg Leu Thr Glu His Asn Glu Thr Ile Leu
        1235                1240                1245            
Phe Lys Glu Lys Phe Leu Asp Trp Thr Glu Leu Lys Arg Ser Asn Glu
    1250                1255                1260                
Lys Asn Pro Gly Glu Leu Ala Gln His Lys Glu Asp Pro Arg Thr Asp
1265                1270                1275                1280
Val Lys Ala Tyr Asp Val Thr Arg Met Val Ser Met Pro Gln Thr Thr
                1285                1290                1295    
Ala Gly Thr Ile Leu Asp Gly Val Asn Val Gly Arg Gly Tyr Gly Leu
            1300                1305                1310        
Val Glu Gly His Asp Arg Arg Gln Phe Glu Ile Thr Ser Val Ser Val
        1315                1320                1325            
Asp Val Trp His Ile Leu Glu Phe Asp Tyr Ser Arg Leu Pro Lys Gln
    1330                1335                1340                
Ser Ile Gly Gln Phe His Glu Gly Asp Ala Tyr Val Val Lys Trp Lys
1345                1350                1355                1360
Phe Met Val Ser Thr Ala Val Gly Ser Arg Gln Lys Gly Glu His Ser
                1365                1370                1375    
Val Arg Ala Ala Gly Lys Glu Lys Cys Val Tyr Phe Phe Trp Gln Gly
            1380                1385                1390        
Arg His Ser Thr Val Ser Glu Lys Gly Thr Ser Ala Leu Met Thr Val
        1395                1400                1405            
Glu Leu Asp Glu Glu Arg Gly Ala Gln Val Gln Val Leu Gln Gly Lys
    1410                1415                1420                
Glu Pro Pro Cys Phe Leu Gln Cys Phe Gln Gly Gly Met Val Val His
1425                1430                1435                1440
Ser Gly Arg Arg Glu Glu Glu Glu Glu Asn Val Gln Ser Glu Trp Arg
                1445                1450                1455    
Leu Tyr Cys Val Arg Gly Glu Val Pro Val Glu Gly Asn Leu Leu Glu
            1460                1465                1470        
Val Ala Cys His Cys Ser Ser Leu Arg Ser Arg Thr Ser Met Val Val
        1475                1480                1485            
Leu Asn Val Asn Lys Ala Leu Ile Tyr Leu Trp His Gly Cys Lys Ala
    1490                1495                1500                
Gln Ala His Thr Lys Glu Val Gly Arg Thr Ala Ala Asn Lys Ile Lys
1505                1510                1515                1520
Glu Gln Cys Pro Leu Glu Ala Gly Leu His Ser Ser Ser Lys Val Thr
                1525                1530                1535    
Ile His Glu Cys Asp Glu Gly Ser Glu Pro Leu Gly Phe Trp Asp Ala
            1540                1545                1550        
Leu Gly Arg Arg Asp Arg Lys Ala Tyr Asp Cys Met Leu Gln Asp Pro
        1555                1560                1565            
Gly Ser Phe Asn Phe Ala Pro Arg Leu Phe Ile Leu Ser Ser Ser Ser
    1570                1575                1580                
Gly Asp Phe Ala Ala Thr Glu Phe Val Tyr Pro Ala Arg Ala Pro Ser
1585                1590                1595                1600
Val Val Ser Ser Met Pro Phe Leu Gln Glu Asp Leu Tyr Ser Ala Pro
                1605                1610                1615    
Gln Pro Ala Leu Phe Leu Val Asp Asn His His Glu Val Tyr Leu Trp
            1620                1625                1630        
Gln Gly Trp Trp Pro Ile Glu Asn Lys Ile Thr Gly Ser Ala Arg Ile
        1635                1640                1645            
Arg Trp Ala Ser Asp Arg Lys Ser Ala Met Glu Thr Val Leu Gln Tyr
    1650                1655                1660                
Cys Lys Gly Lys Asn Leu Lys Lys Pro Ala Pro Lys Ser Tyr Leu Ile
1665                1670                1675                1680
His Ala Gly Leu Glu Pro Leu Thr Phe Thr Asn Met Phe Pro Ser Trp
                1685                1690                1695    
Glu His Arg Glu Asp Ile Ala Glu Ile Thr Glu Met Asp Thr Glu Val
            1700                1705                1710        
Ser Asn Gln Ile Thr Leu Val Glu Asp Val Leu Ala Lys Leu Cys Lys
        1715                1720                1725            
Thr Ile Tyr Pro Leu Ala Asp Leu Leu Ala Arg Pro Leu Pro Glu Gly
    1730                1735                1740                
Val Asp Pro Leu Lys Leu Glu Ile Tyr Leu Thr Asp Glu Asp Phe Glu
1745                1750                1755                1760
Phe Ala Leu Asp Met Thr Arg Asp Glu Tyr Asn Ala Leu Pro Ala Trp
                1765                1770                1775    
Lys Gln Val Asn Leu Lys Lys Ala Lys Gly Leu Phe
            1780                1785            


<210> 2266
<211> 116
<212> PRT
<213> Homo sapiens

<400> 2266
Met Arg Ile Arg Thr Glu Gly Leu Arg Pro Ser Cys Leu Gly Ala Lys
 1               5                  10                  15      
His Leu Leu Trp Asp Val Ala Ala Glu Glu Gly Lys Ala Glu Gly Ala
            20                  25                  30          
Asp Ser Thr Ala Ser Trp Gly Val Val Lys Ala Ser Cys Gly Gly Pro
        35                  40                  45              
Ser Leu Ala Ala Lys Trp Arg Thr Ala Pro Ser Met Pro Gly Phe Val
    50                  55                  60                  
Thr Arg Ser Phe Ser Met Leu Ser Cys Trp His Ile Ala Ala Gln Leu
65                  70                  75                  80  
Glu Met Tyr Gly Cys Pro His Leu Asp Leu Thr Glu Ser Glu Val Gln
                85                  90                  95      
Pro Gln Glu Arg Ser Leu His Pro Leu Gly Phe Leu Cys Ser Ala Asn
            100                 105                 110         
Thr Ser Gly Ile
        115     


<210> 2267
<211> 1646
<212> PRT
<213> Homo sapiens

<400> 2267
Met Trp His Gly Asn His Val Gln Pro Gly Ala Thr His Arg Pro Asn
 1               5                  10                  15      
Gln Gly Leu Glu Met Leu Gln Gly Leu Gly Ile Gly Met Lys Ala Phe
            20                  25                  30          
His Asn Phe Asn Tyr Phe Leu Phe Phe Tyr Asn Val Leu Leu Gly Leu
        35                  40                  45              
Gly Ala Cys Leu Ser Arg Leu Leu Ile Ser Cys Leu Leu Gly Met Trp
    50                  55                  60                  
Leu Ile Ala Arg Ile Asp Arg Thr Ile Met Gln Ser Gly Tyr Glu Gly
65                  70                  75                  80  
Ala Asp Met Gly Phe Ser Ala Trp Ile Gly Met Leu Tyr Met Asp His
                85                  90                  95      
Tyr His Ile Asn Pro Val Leu Val Ser Phe Cys His Ile Leu Ile Thr
            100                 105                 110         
Asn His Arg Glu Lys Lys Leu Gln Gln Ser Thr Lys Tyr Trp Cys Leu
        115                 120                 125             
Asn Gln Ser Ala Glu Ser Leu Arg Ile Cys Ala Met Arg Gly Gly Glu
    130                 135                 140                 
Asn Arg Pro Pro Ala Arg Val Gln Ser Ser Ser Glu Glu Leu Glu Leu
145                 150                 155                 160 
Arg His Gln Ser Leu Asp Ala Phe Pro Gly Arg Arg Leu Pro Gly Arg
                165                 170                 175     
Gly Ile Gln Pro Ala Ala Lys Met Ser Ser Val Gly Lys Val Thr Gln
            180                 185                 190         
Val Pro Asn Gly Lys Ala Tyr Gln Gln Ile Phe Gln Ala Glu Val Gln
        195                 200                 205             
Leu Val His Ser Leu Ala Ala Thr Arg Lys Arg Ala Ala Glu Arg Ser
    210                 215                 220                 
Val Thr Leu Lys Ser Gly Arg Ile Pro Met Met Lys Lys Val Glu Thr
225                 230                 235                 240 
Pro Glu Gly Glu Val Met Ser Pro Arg Gln Gln Lys Trp Met His Ser
                245                 250                 255     
Leu Pro Asn Asp Trp Ile Met Glu Asn Pro Val Leu His Arg Glu Lys
            260                 265                 270         
Glu Arg Ala Lys Arg Glu Lys Ala Arg Glu Ser Glu Asn Thr Ile Ala
        275                 280                 285             
Ala Arg Glu Val Arg Gly Leu Met Asp Thr Ile Val Pro Glu Lys Ile
    290                 295                 300                 
Ser Thr Ser Thr Phe Gln Arg Gln Ala Glu His Lys Arg Lys Ser Tyr
305                 310                 315                 320 
Glu Ser Ala Leu Ala Ser Phe Gln Glu Glu Ile Ala Gln Val Gly Lys
                325                 330                 335     
Glu Met Glu Pro Leu Ile Val Asp Thr Gly Gly Leu Phe Leu Lys Lys
            340                 345                 350         
Leu Thr Glu Ser Asp Glu Glu Met Asn Arg Leu Phe Leu Lys Val Glu
        355                 360                 365             
Asn Asp Thr Asn Leu Glu Asp Tyr Thr Ile Gln Ala Leu Leu Glu Leu
    370                 375                 380                 
Trp Asp Lys Val Ala Gly Arg Leu Leu Leu Arg Lys Gln Glu Ile Lys
385                 390                 395                 400 
Glu Leu Asp Glu Ala Leu His Ser Leu Glu Phe Ser Arg Thr Asp Lys
                405                 410                 415     
Leu Lys Ser Val Leu Lys Lys Tyr Ala Glu Val Ile Glu Lys Thr Ser
            420                 425                 430         
Tyr Leu Met Arg Pro Glu Val Tyr Arg Leu Ile Asn Glu Glu Ala Met
        435                 440                 445             
Val Met Asn Tyr Ala Leu Leu Gly Asn Arg Lys Ala Leu Ala Gln Leu
    450                 455                 460                 
Phe Val Asn Leu Met Glu Ser Thr Leu Gln Gln Glu Leu Asp Ser Arg
465                 470                 475                 480 
His Arg Trp Gln Gly Leu Val Asp Thr Trp Lys Ala Leu Lys Lys Glu
                485                 490                 495     
Ala Leu Leu Gln Ser Phe Ser Glu Phe Met Ala Ser Glu Ser Ile His
            500                 505                 510         
Thr Pro Pro Ala Val Thr Lys Glu Leu Glu Val Met Leu Lys Thr Gln
        515                 520                 525             
Asn Val Leu Gln Gln Arg Arg Leu Lys His Leu Cys Thr Ile Cys Asp
    530                 535                 540                 
Leu Leu Pro Pro Ser Tyr Ser Lys Thr Gln Leu Thr Glu Trp His Ser
545                 550                 555                 560 
Ser Leu Asn Ser Leu Asn Lys Glu Leu Asp Thr Tyr His Val Asp Cys
                565                 570                 575     
Met Met Arg Ile Arg Leu Leu Tyr Glu Lys Thr Trp Gln Glu Cys Leu
            580                 585                 590         
Met His Val Gln Asn Cys Lys Lys Gln Leu Leu Asp Trp Lys Ala Phe
        595                 600                 605             
Thr Glu Glu Glu Ala Glu Thr Leu Val Asn Gln Phe Phe Phe Gln Met
    610                 615                 620                 
Val Gly Ala Leu Gln Gly Lys Val Glu Glu Asp Leu Glu Leu Leu Asp
625                 630                 635                 640 
Lys Ser Phe Glu Thr Leu Ala Asp Gln Thr Glu Trp Gln Ser Ser His
                645                 650                 655     
Leu Phe Lys Tyr Phe Gln Glu Val Val Gln Leu Trp Glu Ala His Gln
            660                 665                 670         
Ser Glu Leu Leu Val Gln Glu Leu Glu Leu Glu Lys Arg Met Glu Gln
        675                 680                 685             
His Arg Gln Lys His Ser Leu Glu Ser Gln Val Gln Glu Ala His Leu
    690                 695                 700                 
Asp Arg Leu Leu Asp Gln Leu Arg Gln Gln Ser Asp Lys Glu Thr Leu
705                 710                 715                 720 
Ala Phe His Leu Glu Lys Val Lys Asp Tyr Leu Lys Asn Met Lys Ser
                725                 730                 735     
Arg Tyr Glu Cys Phe His Thr Leu Leu Thr Lys Glu Val Met Glu Tyr
            740                 745                 750         
Pro Ala Ile Met Leu Lys Glu Leu Asn Ser Tyr Ser Ser Ala Leu Ser
        755                 760                 765             
Gln Tyr Phe Phe Val Arg Glu Ile Phe Glu Gln Asn Leu Ala Gly Glu
    770                 775                 780                 
Val Ile Phe Lys Phe Arg Gln Pro Glu Ala His Glu Lys Pro Ser Gln
785                 790                 795                 800 
Lys Arg Val Lys Lys Leu Arg Lys Lys Gln Gly Ser Lys Glu Asp Met
                805                 810                 815     
Thr Arg Ser Glu Glu Ser Ile Ser Ser Gly Thr Ser Thr Ala Arg Ser
            820                 825                 830         
Val Glu Glu Val Glu Glu Glu Asn Asp Gln Glu Met Glu Ser Phe Ile
        835                 840                 845             
Thr Glu Glu Val Leu Gly Gln Gln Lys Lys Ser Pro Leu His Ala Lys
    850                 855                 860                 
Met Asp Glu Ser Lys Glu Gly Ser Ile Gln Gly Leu Glu Glu Met Gln
865                 870                 875                 880 
Val Glu Arg Glu Gly Ser Leu Asn Pro Ser Leu Asn Glu Glu Asn Val
                885                 890                 895     
Lys Gly Gln Gly Glu Lys Lys Glu Glu Ser Glu Glu Glu Asp Glu Lys
            900                 905                 910         
Glu Glu Glu Glu Glu Glu Glu Lys Leu Glu Glu Glu Lys Glu Glu Lys
        915                 920                 925             
Glu Ala Gln Glu Glu Gln Glu Ser Leu Ser Val Gly Glu Glu Glu Asp
    930                 935                 940                 
Lys Glu Glu Gly Leu Glu Glu Ile Tyr Tyr Glu Asp Met Glu Ser Phe
945                 950                 955                 960 
Thr Ile Ser Ser Gly Asn Thr Tyr Phe Val Phe Val Pro Leu Glu Glu
                965                 970                 975     
Glu His Cys Arg Lys Ser His Ser Thr Phe Ser Ala Met Phe Ile Asn
            980                 985                 990         
Asp Thr Ser Ser Ala Lys Phe Ile Glu Gln Val Thr Ile Pro Ser Arg
        995                 1000                1005            
Leu Ile Leu Glu Ile Lys Lys Gln Leu Phe Ser Glu Gly Gly Asn Phe
    1010                1015                1020                
Ser Pro Lys Glu Ile Asn Ser Leu Cys Ser Arg Leu Glu Lys Glu Ala
1025                1030                1035                1040
Ala Arg Ile Glu Leu Val Glu Ser Val Ile Met Leu Asn Met Glu Lys
                1045                1050                1055    
Leu Glu Asn Glu Tyr Leu Asp Gln Ala Asn Asp Val Ile Asn Lys Phe
            1060                1065                1070        
Glu Ser Lys Phe His Asn Leu Ser Val Asp Leu Ile Phe Ile Glu Lys
        1075                1080                1085            
Ile Gln Arg Leu Leu Thr Asn Leu Gln Val Lys Ile Lys Cys Gln Val
    1090                1095                1100                
Ala Lys Ser Asn Ser Gln Thr Asn Gly Leu Asn Phe Ser Leu Gln Gln
1105                1110                1115                1120
Leu Gln Asn Lys Ile Lys Thr Cys Gln Glu Ser Arg Gly Glu Lys Thr
                1125                1130                1135    
Thr Val Thr Thr Glu Glu Leu Leu Ser Phe Val Gln Thr Trp Lys Glu
            1140                1145                1150        
Lys Leu Ser Gln Arg Ile Gln Tyr Leu Asn Cys Ser Leu Asp Arg Val
        1155                1160                1165            
Ser Met Thr Glu Leu Val Phe Thr Asn Thr Ile Leu Lys Asp Gln Glu
    1170                1175                1180                
Glu Asp Ser Asp Ile Leu Thr Ser Ser Glu Ala Leu Glu Glu Glu Ala
1185                1190                1195                1200
Lys Leu Asp Val Val Thr Pro Glu Ser Phe Thr Gln Leu Ser Arg Val
                1205                1210                1215    
Gly Lys Pro Leu Ile Glu Asp Pro Ala Val Asp Val Ile Arg Lys Leu
            1220                1225                1230        
Leu Gln Leu Pro Asn Thr Lys Trp Pro Thr His His Cys Asp Lys Asp
        1235                1240                1245            
Pro Ser Gln Thr Gly Phe Lys Arg His Arg Cys Gln Pro Glu Asn Ser
    1250                1255                1260                
Gly Lys Lys Ala Val Pro Ser Ala Ser Ala Thr Ser Ala Gly Ser Leu
1265                1270                1275                1280
Gln Thr Thr His Pro Pro Leu Ser His Ser Phe Thr Pro His Pro Lys
                1285                1290                1295    
Pro Asn Lys Met Glu Arg Lys Tyr Arg Val Leu Gly Asp Lys Pro Pro
            1300                1305                1310        
Pro Ala Ala Glu Asp Phe Lys Gly Ile Ile Leu Thr Leu Leu Trp Glu
        1315                1320                1325            
Ser Ser Glu Asn Leu Leu Thr Val Ala Glu Glu Phe Tyr Arg Lys Glu
    1330                1335                1340                
Lys Arg Pro Val Thr Arg Pro Asp Cys Met Cys Asp Thr Phe Asp Gln
1345                1350                1355                1360
Cys Ala Glu Asn Ile Ser Lys Lys Ile Leu Glu Tyr Gln Ser Gln Ala
                1365                1370                1375    
Asn Lys Tyr His Asn Ser Cys Leu Ile Glu Leu Arg Ile Gln Ile Arg
            1380                1385                1390        
Arg Phe Glu Glu Leu Leu Pro Gln Val Cys Trp Leu Val Met Glu Asn
        1395                1400                1405            
Phe Lys Glu His His Trp Lys Lys Phe Phe Thr Ser Val Lys Glu Ile
    1410                1415                1420                
Arg Gly Gln Phe Glu Glu Gln Gln Lys Arg Leu Glu Lys Arg Lys Asp
1425                1430                1435                1440
Lys Asn Ala Gln Lys Leu His Leu Asn Leu Gly His Pro Val His Phe
                1445                1450                1455    
Gln Glu Met Glu Ser Leu His Leu Ser Glu Glu Glu Arg Gln Glu Glu
            1460                1465                1470        
Leu Asp Ser Met Ile Arg Met Asn Lys Glu Lys Leu Glu Glu Cys Thr
        1475                1480                1485            
Arg Arg Asn Gly Gln Val Phe Ile Thr Asn Leu Ala Thr Phe Thr Glu
    1490                1495                1500                
Lys Phe Leu Leu Gln Leu Asp Glu Val Val Thr Ile Asp Asp Val Gln
1505                1510                1515                1520
Val Ala Arg Met Glu Pro Pro Lys Gln Lys Leu Ser Met Leu Ile Arg
                1525                1530                1535    
Arg Lys Leu Ala Gly Leu Ser Leu Lys Glu Glu Ser Glu Lys Pro Leu
            1540                1545                1550        
Ile Glu Arg Gly Ser Arg Lys Trp Pro Gly Ile Lys Pro Thr Glu Val
        1555                1560                1565            
Thr Ile Gln Asn Lys Ile Leu Leu Gln Pro Thr Ser Ser Ile Ser Thr
    1570                1575                1580                
Thr Lys Thr Thr Leu Gly His Leu Ala Ala Val Glu Ala Arg Asp Ala
1585                1590                1595                1600
Val Tyr Leu Lys Tyr Leu Ala Ser Phe Glu Glu Glu Leu Lys Arg Ile
                1605                1610                1615    
Gln Asp Asp Cys Thr Ser Gln Ile Lys Glu Ala Gln Arg Trp Lys Asp
            1620                1625                1630        
Ser Trp Lys Gln Ser Leu His Thr Ile Gln Gly Leu Tyr Val
        1635                1640                1645    


<210> 2268
<211> 208
<212> PRT
<213> Homo sapiens

<400> 2268
Met Ser Thr Gly Gly Asp Phe Gly Asn Pro Leu Arg Lys Phe Lys Leu
 1               5                  10                  15      
Val Phe Leu Gly Glu Gln Ser Val Gly Lys Thr Ser Leu Ile Thr Arg
            20                  25                  30          
Phe Met Tyr Asp Ser Phe Asp Asn Thr Tyr Gln Ala Thr Ile Gly Ile
        35                  40                  45              
Asp Phe Leu Ser Lys Thr Met Tyr Leu Glu Asp Arg Thr Ile Arg Leu
    50                  55                  60                  
Gln Leu Trp Asp Thr Ala Gly Gln Glu Arg Phe Arg Ser Leu Ile Pro
65                  70                  75                  80  
Ser Tyr Ile Arg Asp Ser Ala Ala Ala Val Val Val Tyr Asp Ile Thr
                85                  90                  95      
Asn Val Asn Ser Phe Gln Gln Thr Thr Lys Trp Ile Asp Asp Val Arg
            100                 105                 110         
Thr Glu Arg Gly Ser Asp Val Ile Ile Met Leu Val Gly Asn Lys Thr
        115                 120                 125             
Asp Leu Ala Asp Lys Arg Gln Val Ser Ile Glu Glu Gly Glu Arg Lys
    130                 135                 140                 
Ala Lys Glu Leu Asn Val Met Phe Ile Glu Thr Ser Ala Lys Ala Gly
145                 150                 155                 160 
Tyr Asn Val Lys Gln Leu Phe Arg Arg Val Ala Ala Ala Leu Pro Gly
                165                 170                 175     
Met Glu Ser Thr Gln Asp Arg Ser Arg Glu Asp Met Ile Asp Ile Lys
            180                 185                 190         
Leu Glu Lys Pro Gln Glu Gln Pro Val Ser Glu Gly Gly Cys Ser Cys
        195                 200                 205             


<210> 2269
<211> 714
<212> PRT
<213> Homo sapiens

<400> 2269
Met Val Thr Arg Leu Leu Gln Gln Gln Asn Leu Pro Gln Thr Gly Glu
 1               5                  10                  15      
Gln Glu Leu Glu Ser Leu Val Leu Lys Leu Ser Val Leu Lys Asp Phe
            20                  25                  30          
Leu Ser Gly Ile Gln Lys Lys Ala Leu Lys Ala Leu Gln Asp Met Ser
        35                  40                  45              
Ser Thr Ala Pro Pro Ala Pro Gln Pro Ser Thr Arg Lys Ala Lys Thr
    50                  55                  60                  
Ile Pro Val Gln Ala Phe Glu Val Lys Leu Asp Val Thr Leu Gly Asp
65                  70                  75                  80  
Leu Thr Lys Ile Gly Lys Ser Gln Lys Phe Thr Leu Ser Val Asp Val
                85                  90                  95      
Glu Gly Gly Arg Leu Val Leu Leu Arg Arg Gln Arg Asp Ser Gln Glu
            100                 105                 110         
Asp Trp Thr Thr Phe Thr His Asp Arg Ile Arg Gln Leu Ile Lys Ser
        115                 120                 125             
Gln Arg Val Gln Asn Lys Leu Gly Val Val Phe Glu Lys Glu Lys Asp
    130                 135                 140                 
Arg Thr Gln Arg Lys Asp Phe Ile Phe Val Ser Ala Arg Lys Arg Glu
145                 150                 155                 160 
Ala Phe Cys Gln Leu Leu Gln Leu Met Lys Asn Lys His Ser Lys Gln
                165                 170                 175     
Asp Glu Pro Asp Met Ile Ser Val Phe Ile Gly Thr Trp Asn Met Gly
            180                 185                 190         
Ser Val Pro Pro Pro Lys Asn Val Thr Ser Trp Phe Thr Ser Lys Gly
        195                 200                 205             
Leu Gly Lys Thr Leu Asp Glu Val Thr Val Thr Ile Pro His Asp Ile
    210                 215                 220                 
Tyr Val Phe Gly Thr Gln Glu Asn Ser Val Gly Asp Arg Glu Trp Leu
225                 230                 235                 240 
Asp Leu Leu Arg Gly Gly Leu Lys Glu Leu Thr Asp Leu Asp Tyr Arg
                245                 250                 255     
Pro Ile Ala Met Gln Ser Leu Trp Asn Ile Lys Val Ala Val Leu Val
            260                 265                 270         
Lys Pro Glu His Glu Asn Arg Ile Ser His Val Ser Thr Ser Ser Val
        275                 280                 285             
Lys Thr Gly Ile Ala Asn Thr Leu Gly Asn Lys Gly Ala Val Gly Val
    290                 295                 300                 
Ser Phe Met Phe Asn Gly Thr Ser Phe Gly Phe Val Asn Cys His Leu
305                 310                 315                 320 
Thr Ser Gly Asn Glu Lys Thr Ala Arg Arg Asn Gln Asn Tyr Leu Asp
                325                 330                 335     
Ile Leu Arg Leu Leu Ser Leu Gly Asp Arg Gln Leu Asn Ala Phe Asp
            340                 345                 350         
Ile Ser Leu Arg Phe Thr His Leu Phe Trp Phe Gly Asp Leu Asn Tyr
        355                 360                 365             
Arg Leu Asp Met Asp Ile Gln Glu Ile Leu Asn Tyr Ile Ser Arg Lys
    370                 375                 380                 
Glu Phe Glu Pro Leu Leu Arg Val Asp Gln Leu Asn Leu Glu Arg Glu
385                 390                 395                 400 
Lys His Lys Val Phe Leu Arg Phe Ser Glu Glu Glu Ile Ser Phe Pro
                405                 410                 415     
Pro Thr Tyr Arg Tyr Glu Arg Gly Ser Arg Asp Thr Tyr Ala Trp His
            420                 425                 430         
Lys Gln Lys Pro Thr Gly Val Arg Thr Asn Val Pro Ser Trp Cys Asp
        435                 440                 445             
Arg Ile Leu Trp Lys Ser Tyr Pro Glu Thr His Ile Ile Cys Asn Ser
    450                 455                 460                 
Tyr Gly Cys Thr Asp Asp Ile Val Thr Ser Asp His Ser Pro Val Phe
465                 470                 475                 480 
Gly Thr Phe Glu Val Gly Val Thr Ser Gln Phe Ile Ser Lys Lys Gly
                485                 490                 495     
Leu Ser Lys Thr Ser Asp Gln Ala Tyr Ile Glu Phe Glu Ser Ile Glu
            500                 505                 510         
Ala Ile Val Lys Thr Ala Ser Arg Thr Lys Phe Phe Ile Glu Phe Tyr
        515                 520                 525             
Ser Thr Cys Leu Glu Glu Tyr Lys Lys Ser Phe Glu Asn Asp Ala Gln
    530                 535                 540                 
Ser Ser Asp Asn Ile Asn Phe Leu Lys Val Gln Trp Ser Ser Arg Gln
545                 550                 555                 560 
Leu Pro Thr Leu Lys Pro Ile Leu Ala Asp Ile Glu Tyr Leu Gln Asp
                565                 570                 575     
Gln His Leu Leu Leu Thr Val Lys Ser Met Asp Gly Tyr Glu Ser Tyr
            580                 585                 590         
Gly Glu Cys Val Val Ala Leu Lys Ser Met Ile Gly Ser Thr Ala Gln
        595                 600                 605             
Gln Phe Leu Thr Phe Leu Ser His Arg Gly Glu Glu Thr Gly Asn Ile
    610                 615                 620                 
Arg Gly Ser Met Lys Val Arg Val Pro Thr Glu Arg Leu Gly Thr Arg
625                 630                 635                 640 
Glu Arg Leu Tyr Gly Gly Ser Ala Leu Ile Arg Met Arg Gln Glu Gln
                645                 650                 655     
Arg Ala Lys Pro Pro Leu Cys Pro Glu Gly Ala Arg Ser Pro Gly Gln
            660                 665                 670         
Gly Ala Ala Ser Gln Pro Ser Gln Arg Pro Pro Ala Arg Ser Pro Gly
        675                 680                 685             
Tyr Leu Lys Asn Gln Arg Asn Arg His Gln Arg Gly Gly Pro Gln Pro
    690                 695                 700                 
His Pro Glu Gln Leu Pro Gly Arg Ser Pro
705                 710                 


<210> 2270
<211> 149
<212> PRT
<213> Homo sapiens

<400> 2270
Met Lys Val Arg Lys Ser Ser Thr Pro Glu Glu Val Lys Lys Arg Lys
 1               5                  10                  15      
Lys Ala Val Leu Phe Cys Leu Ser Glu Asp Lys Lys Asn Ile Ile Leu
            20                  25                  30          
Glu Glu Gly Lys Glu Ile Leu Val Gly Asp Val Gly Gln Thr Val Asp
        35                  40                  45              
Asp Pro Tyr Ala Thr Phe Val Lys Met Leu Pro Asp Lys Asp Cys Arg
    50                  55                  60                  
Tyr Ala Leu Tyr Asp Ala Thr Tyr Glu Thr Lys Glu Ser Lys Lys Glu
65                  70                  75                  80  
Asp Leu Val Phe Ile Phe Trp Ala Pro Glu Ser Ala Pro Leu Lys Ser
                85                  90                  95      
Lys Met Ile Tyr Ala Ser Ser Lys Asp Ala Ile Lys Lys Lys Leu Thr
            100                 105                 110         
Gly Ile Lys His Glu Leu Gln Ala Asn Cys Tyr Glu Glu Val Lys Asp
        115                 120                 125             
Arg Cys Thr Leu Ala Glu Lys Leu Gly Gly Ser Ala Val Ile Ser Leu
    130                 135                 140                 
Glu Gly Lys Pro Leu
145                 


<210> 2271
<211> 388
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82,
83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96,
97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108,
109, 110, 111, 112, 113, 114, 115, 116, 117, 118
<223> Xaa = Any Amino Acid

<400> 2271
Met Glu Ser Gly Glu His Ala Gly Leu Gly Val Gln Phe Pro Gln Ala
 1               5                  10                  15      
Gly Glu Ala Gln Asn Gly Arg Arg Arg Ser Arg Met Asp Glu Ala Thr
            20                  25                  30          
Trp Tyr Leu Asp Ser Asp Asp Ser Ser Pro Leu Gly Ser Pro Ser Thr
        35                  40                  45              
Pro Pro Ala Leu Asn Gly Asn Pro Pro Arg Pro Ser Leu Glu Pro Glu
    50                  55                  60                  
Glu Pro Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
65                  70                  75                  80  
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
                85                  90                  95      
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            100                 105                 110         
Xaa Xaa Xaa Xaa Xaa Xaa Thr Thr Pro Pro Thr Pro Thr Pro Ala Pro
        115                 120                 125             
Cys Pro Thr Glu Pro Pro Leu Pro Arg Ser Ser Ala Ser Arg Ser Arg
    130                 135                 140                 
Arg Pro Thr Pro Arg Pro Leu Leu His Pro Cys Cys Trp Thr Trp Val
145                 150                 155                 160 
Ser Leu Trp Ala Ser Gly Gln Pro Arg Ala Pro Asp Val Arg Arg Ser
                165                 170                 175     
Pro Ala Glu Ala Leu Ser His Pro His Arg Gly His His Ala Leu Leu
            180                 185                 190         
Leu Ala Pro Gln Ala Pro His Val His His Pro Trp Ala Ser Ser Ala
        195                 200                 205             
Asp Leu Gly Pro Arg Pro Phe Ala Ala Ala Leu Ile Pro Gly Ala Leu
    210                 215                 220                 
Cys Gln Leu Gly His Gly Leu Leu Pro Cys His His His Ser Leu His
225                 230                 235                 240 
Pro Ala Glu His Pro Gly Pro Cys Ser Arg Thr Gln Thr Pro Ser Gly
                245                 250                 255     
Thr Pro His Leu Pro Thr Pro Ser Arg Gly Ala Pro Arg Thr Ala Gly
            260                 265                 270         
His Arg Pro Lys Thr Trp Val Pro Arg Pro Arg Gly Cys Arg Lys Arg
        275                 280                 285             
Gly Leu Glu Trp Ala Arg Pro Leu Pro Arg Ala Pro Ala Ala Leu Gly
    290                 295                 300                 
Gly Val Thr Ala Tyr Thr Gly Thr Gly Ala Gly Ser Ala Ser Ala Ala
305                 310                 315                 320 
Ala Ser Val Ser Pro Gly Thr Pro Pro Pro Phe Gly Gly Gln Glu His
                325                 330                 335     
Tyr Thr Ala Gln Glu Ala Phe Thr Leu Glu Gly Gly Pro Ala Pro Pro
            340                 345                 350         
His Leu Lys Pro Val Gly Pro Pro Ser Ser Pro Ala Leu Leu Gly Pro
        355                 360                 365             
Asn Thr Val Pro Ser Trp Leu Gly Gly Pro Glu Pro Val Ser Gly Asn
    370                 375                 380                 
Cys Leu Leu Gly
385             


<210> 2272
<211> 1189
<212> PRT
<213> Homo sapiens

<400> 2272
Met Lys Thr Arg Gln Asn Lys Asp Ser Met Ser Met Arg Ser Gly Arg
 1               5                  10                  15      
Lys Lys Glu Ala Pro Gly Pro Arg Glu Glu Leu Arg Ser Arg Gly Arg
            20                  25                  30          
Ala Ser Pro Gly Gly Val Ser Thr Ser Ser Ser Asp Gly Lys Ala Glu
        35                  40                  45              
Lys Ser Arg Gln Thr Ala Lys Lys Ala Arg Val Glu Glu Ala Ser Thr
    50                  55                  60                  
Pro Lys Val Asn Lys Gln Gly Arg Ser Glu Glu Ile Ser Glu Ser Glu
65                  70                  75                  80  
Ser Glu Glu Thr Asn Ala Pro Lys Lys Thr Lys Thr Glu Glu Leu Pro
                85                  90                  95      
Arg Pro Gln Ser Pro Ser Asp Leu Asp Ser Leu Asp Gly Arg Ser Leu
            100                 105                 110         
Asn Asp Asp Gly Ser Ser Asp Pro Arg Asp Ile Asp Gln Asp Asn Arg
        115                 120                 125             
Ser Thr Ser Pro Ser Ile Tyr Ser Pro Gly Ser Val Glu Asn Asp Ser
    130                 135                 140                 
Asp Ser Ser Ser Gly Leu Ser Gln Gly Pro Ala Arg Pro Tyr His Pro
145                 150                 155                 160 
Pro Pro Leu Phe Pro Pro Ser Pro Gln Pro Pro Asp Ser Thr Pro Arg
                165                 170                 175     
Gln Pro Glu Ala Ser Phe Glu Pro His Pro Ser Val Thr Pro Thr Gly
            180                 185                 190         
Tyr His Ala Pro Met Glu Pro Pro Thr Ser Arg Met Phe Gln Ala Pro
        195                 200                 205             
Pro Gly Ala Pro Pro Pro His Pro Gln Leu Tyr Pro Gly Gly Thr Gly
    210                 215                 220                 
Gly Val Leu Ser Gly Pro Pro Met Gly Pro Lys Gly Gly Gly Ala Ala
225                 230                 235                 240 
Ser Ser Val Gly Gly Pro Asn Gly Gly Lys Gln His Pro Pro Pro Thr
                245                 250                 255     
Thr Pro Ile Ser Val Ser Ser Ser Gly Ala Ser Gly Ala Pro Pro Thr
            260                 265                 270         
Lys Pro Pro Thr Thr Pro Val Gly Gly Gly Asn Leu Pro Ser Ala Pro
        275                 280                 285             
Pro Pro Ala Asn Phe Pro His Val Thr Pro Asn Leu Pro Pro Pro Pro
    290                 295                 300                 
Ala Leu Arg Pro Leu Asn Asn Ala Ser Ala Ser Pro Pro Gly Leu Gly
305                 310                 315                 320 
Ala Gln Pro Leu Pro Gly His Leu Pro Ser Pro His Ala Met Gly Gln
                325                 330                 335     
Gly Met Gly Gly Leu Pro Pro Gly Pro Glu Lys Gly Pro Thr Leu Ala
            340                 345                 350         
Pro Ser Pro His Ser Leu Pro Pro Ala Ser Ser Ser Ala Pro Ala Pro
        355                 360                 365             
Pro Met Arg Phe Pro Tyr Ser Ser Ser Ser Ser Ser Ser Ala Ala Ala
    370                 375                 380                 
Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ala Ser Pro Phe Pro Ala
385                 390                 395                 400 
Ser Gln Ala Leu Pro Ser Tyr Pro His Ser Phe Pro Pro Pro Thr Ser
                405                 410                 415     
Leu Ser Val Ser Asn Gln Pro Pro Lys Tyr Thr Gln Pro Ser Leu Pro
            420                 425                 430         
Ser Gln Ala Val Trp Ser Gln Gly Pro Pro Pro Pro Pro Pro Tyr Gly
        435                 440                 445             
Arg Leu Leu Ala Asn Ser Asn Ala His Pro Gly Pro Phe Pro Pro Ser
    450                 455                 460                 
Thr Gly Ala Gln Ser Thr Ala His Pro Pro Val Ser Thr His His His
465                 470                 475                 480 
His His Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
                485                 490                 495     
Gln Gln Gln Gln Gln His His Gly Asn Ser Gly Pro Pro Pro Pro Gly
            500                 505                 510         
Ala Phe Pro His Pro Leu Glu Gly Gly Ser Ser His His Ala His Pro
        515                 520                 525             
Tyr Ala Met Ser Pro Ser Leu Gly Ser Leu Arg Pro Tyr Pro Pro Gly
    530                 535                 540                 
Pro Ala His Leu Pro Pro Pro His Ser Gln Val Ser Tyr Ser Gln Ala
545                 550                 555                 560 
Gly Pro Asn Gly Pro Pro Val Ser Ser Ser Ser Asn Ser Ser Ser Ser
                565                 570                 575     
Thr Ser Gln Gly Ser Tyr Pro Cys Ser His Pro Ser Pro Ser Gln Gly
            580                 585                 590         
Pro Gln Gly Ala Pro Tyr Pro Phe Pro Pro Val Pro Thr Val Thr Thr
        595                 600                 605             
Ser Ser Ala Thr Leu Ser Thr Val Ile Ala Thr Val Ala Ser Ser Pro
    610                 615                 620                 
Ala Gly Tyr Lys Thr Ala Ser Pro Pro Gly Pro Pro Pro Tyr Gly Lys
625                 630                 635                 640 
Arg Ala Pro Ser Pro Gly Ala Tyr Lys Thr Ala Thr Pro Pro Gly Tyr
                645                 650                 655     
Lys Pro Gly Ser Pro Pro Ser Phe Arg Thr Gly Thr Pro Pro Gly Tyr
            660                 665                 670         
Arg Gly Thr Ser Pro Pro Ala Gly Pro Gly Thr Phe Lys Pro Gly Ser
        675                 680                 685             
Pro Thr Val Gly Pro Gly Pro Leu Pro Pro Ala Gly Pro Ser Gly Leu
    690                 695                 700                 
Pro Ser Leu Pro Pro Pro Pro Ala Ala Pro Ala Ser Gly Pro Pro Leu
705                 710                 715                 720 
Ser Ala Thr Gln Ile Lys Gln Glu Pro Ala Glu Glu Tyr Glu Thr Pro
                725                 730                 735     
Glu Ser Pro Val Pro Pro Ala Arg Ser Pro Ser Pro Pro Pro Lys Val
            740                 745                 750         
Val Asp Val Pro Ser His Ala Ser Gln Ser Ala Arg Phe Asn Lys His
        755                 760                 765             
Leu Asp Arg Gly Phe Asn Ser Cys Ala Arg Ser Asp Leu Tyr Phe Val
    770                 775                 780                 
Pro Leu Glu Gly Ser Lys Leu Ala Lys Lys Arg Ala Asp Leu Val Glu
785                 790                 795                 800 
Lys Val Arg Arg Glu Ala Glu Gln Arg Ala Arg Glu Glu Lys Glu Arg
                805                 810                 815     
Glu Arg Glu Arg Glu Arg Glu Lys Glu Arg Glu Arg Glu Lys Glu Arg
            820                 825                 830         
Glu Leu Glu Arg Ser Val Lys Leu Ala Gln Glu Gly Arg Ala Pro Val
        835                 840                 845             
Glu Cys Pro Ser Leu Gly Pro Val Pro His Arg Pro Pro Phe Glu Pro
    850                 855                 860                 
Gly Ser Ala Val Ala Thr Val Pro Pro Tyr Leu Gly Pro Asp Thr Pro
865                 870                 875                 880 
Ala Leu Arg Thr Leu Ser Glu Tyr Ala Arg Pro His Val Met Ser Pro
                885                 890                 895     
Gly Asn Arg Asn His Pro Phe Tyr Val Pro Leu Gly Ala Val Asp Pro
            900                 905                 910         
Gly Leu Leu Gly Tyr Asn Val Pro Ala Leu Tyr Ser Ser Asp Pro Ala
        915                 920                 925             
Ala Arg Glu Arg Glu Arg Glu Ala Arg Glu Arg Asp Leu Arg Asp Arg
    930                 935                 940                 
Leu Lys Pro Gly Phe Glu Val Lys Pro Ser Glu Leu Glu Pro Leu His
945                 950                 955                 960 
Gly Val Pro Gly Pro Gly Leu Asp Pro Phe Pro Arg His Gly Gly Leu
                965                 970                 975     
Ala Leu Gln Pro Gly Pro Pro Gly Leu His Pro Phe Pro Phe His Pro
            980                 985                 990         
Ser Leu Gly Pro Leu Glu Arg Glu Arg Leu Ala Leu Ala Ala Gly Pro
        995                 1000                1005            
Ala Leu Arg Pro Asp Met Ser Tyr Ala Glu Arg Leu Ala Ala Glu Arg
    1010                1015                1020                
Gln His Ala Glu Arg Val Ala Ala Leu Gly Asn Asp Pro Leu Ala Arg
1025                1030                1035                1040
Leu Gln Met Leu Asn Val Thr Pro His His His Gln His Ser His Ile
                1045                1050                1055    
His Ser His Leu His Leu His Gln Gln Asp Ala Ile His Ala Ala Ser
            1060                1065                1070        
Ala Ser Val His Pro Leu Ile Asp Pro Leu Ala Ser Gly Ser His Leu
        1075                1080                1085            
Thr Arg Ile Pro Tyr Pro Ala Gly Thr Leu Pro Asn Pro Leu Leu Pro
    1090                1095                1100                
His Pro Leu His Glu Asn Glu Val Leu Arg His Gln Leu Phe Ala Ala
1105                1110                1115                1120
Pro Tyr Arg Asp Leu Pro Ala Ser Leu Ser Ala Pro Met Ser Ala Ala
                1125                1130                1135    
His Gln Leu Gln Ala Met His Ala Gln Ser Ala Glu Leu Gln Arg Leu
            1140                1145                1150        
Ala Leu Glu Gln Gln Gln Trp Leu His Ala His His Pro Leu His Ser
        1155                1160                1165            
Val Pro Leu Pro Ala Gln Glu Asp Tyr Tyr Ser His Leu Lys Lys Glu
    1170                1175                1180                
Ser Asp Lys Pro Leu
1185                


<210> 2273
<211> 858
<212> PRT
<213> Homo sapiens

<400> 2273
Met Ala Glu Leu Ser Glu Glu Ala Leu Leu Ser Val Leu Pro Thr Ile
 1               5                  10                  15      
Arg Val Pro Lys Ala Gly Asp Arg Val His Lys Asp Glu Cys Ala Phe
            20                  25                  30          
Ser Phe Asp Thr Pro Glu Ser Glu Gly Gly Leu Tyr Ile Cys Met Asn
        35                  40                  45              
Thr Phe Leu Gly Phe Gly Lys Gln Tyr Val Glu Arg His Phe Asn Lys
    50                  55                  60                  
Thr Gly Gln Arg Val Tyr Leu His Leu Arg Arg Thr Arg Arg Pro Lys
65                  70                  75                  80  
Glu Glu Asp Pro Ala Thr Gly Thr Gly Asp Pro Pro Arg Lys Lys Pro
                85                  90                  95      
Thr Arg Leu Ala Ile Gly Val Glu Gly Gly Phe Asp Leu Ser Glu Glu
            100                 105                 110         
Lys Phe Glu Leu Asp Glu Asp Val Lys Ile Val Ile Leu Pro Asp Tyr
        115                 120                 125             
Leu Glu Ile Ala Arg Asp Gly Leu Gly Gly Leu Pro Asp Ile Val Arg
    130                 135                 140                 
Asp Arg Val Thr Ser Ala Val Glu Ala Leu Leu Ser Ala Asp Ser Ala
145                 150                 155                 160 
Ser Arg Lys Gln Glu Val Gln Ala Trp Asp Gly Glu Val Arg Gln Val
                165                 170                 175     
Ser Lys His Ala Phe Ser Leu Lys Gln Leu Asp Asn Pro Ala Arg Ile
            180                 185                 190         
Pro Pro Cys Gly Trp Lys Cys Ser Lys Cys Asp Met Arg Glu Asn Leu
        195                 200                 205             
Trp Leu Asn Leu Thr Asp Gly Ser Ile Leu Cys Gly Arg Arg Tyr Phe
    210                 215                 220                 
Asp Gly Ser Gly Gly Asn Asn His Ala Val Glu His Tyr Arg Glu Thr
225                 230                 235                 240 
Gly Tyr Pro Leu Ala Val Lys Leu Gly Thr Ile Thr Pro Asp Gly Ala
                245                 250                 255     
Asp Val Tyr Ser Tyr Asp Glu Asp Asp Met Val Leu Asp Pro Ser Leu
            260                 265                 270         
Ala Glu His Leu Ser His Phe Gly Ile Asp Met Leu Lys Met Gln Lys
        275                 280                 285             
Thr Asp Lys Thr Met Thr Glu Leu Glu Ile Asp Met Asn Gln Arg Ile
    290                 295                 300                 
Gly Glu Trp Glu Leu Ile Gln Glu Ser Gly Val Pro Leu Lys Pro Leu
305                 310                 315                 320 
Phe Gly Pro Gly Tyr Thr Gly Ile Arg Asn Leu Gly Asn Ser Cys Tyr
                325                 330                 335     
Leu Asn Ser Val Val Gln Val Leu Phe Ser Ile Pro Asp Phe Gln Arg
            340                 345                 350         
Lys Tyr Val Asp Lys Leu Glu Lys Ile Phe Gln Asn Ala Pro Thr Asp
        355                 360                 365             
Pro Thr Gln Asp Phe Ser Thr Gln Val Ala Lys Leu Gly His Gly Leu
    370                 375                 380                 
Leu Ser Gly Glu Tyr Ser Lys Pro Val Pro Glu Ser Gly Asp Gly Glu
385                 390                 395                 400 
Arg Val Pro Glu Gln Lys Glu Val Gln Asp Gly Ile Ala Pro Arg Met
                405                 410                 415     
Phe Lys Ala Leu Ile Gly Lys Gly His Pro Glu Phe Ser Thr Asn Arg
            420                 425                 430         
Gln Gln Asp Ala Gln Glu Phe Phe Leu His Leu Ile Asn Met Val Glu
        435                 440                 445             
Arg Asn Cys Arg Ser Ser Glu Asn Pro Asn Glu Val Phe Arg Phe Leu
    450                 455                 460                 
Val Glu Glu Lys Ile Lys Cys Leu Ala Thr Glu Lys Val Lys Tyr Thr
465                 470                 475                 480 
Gln Arg Val Asp Tyr Ile Met Gln Leu Pro Val Pro Met Asp Ala Ala
                485                 490                 495     
Leu Asn Lys Glu Glu Leu Leu Glu Tyr Glu Glu Lys Lys Arg Gln Ala
            500                 505                 510         
Glu Glu Glu Lys Met Ala Leu Pro Glu Leu Val Arg Ala Gln Val Pro
        515                 520                 525             
Phe Ser Ser Cys Leu Glu Ala Tyr Gly Ala Pro Glu Gln Val Asp Asp
    530                 535                 540                 
Phe Trp Ser Thr Ala Leu Gln Ala Lys Ser Val Ala Val Lys Thr Thr
545                 550                 555                 560 
Arg Phe Ala Ser Phe Pro Asp Tyr Leu Val Ile Gln Ile Lys Lys Phe
                565                 570                 575     
Thr Phe Gly Leu Asp Trp Val Pro Lys Lys Leu Asp Val Ser Ile Glu
            580                 585                 590         
Met Pro Glu Glu Leu Asp Ile Ser Gln Leu Arg Gly Thr Gly Leu Gln
        595                 600                 605             
Pro Gly Glu Glu Glu Leu Pro Asp Ile Ala Pro Pro Leu Val Thr Pro
    610                 615                 620                 
Asp Glu Pro Lys Gly Ser Leu Gly Phe Tyr Gly Asn Glu Asp Glu Asp
625                 630                 635                 640 
Ser Phe Cys Ser Pro His Phe Ser Ser Pro Thr Ser Pro Met Leu Asp
                645                 650                 655     
Glu Ser Val Ile Ile Gln Leu Val Glu Met Gly Phe Pro Met Asp Ala
            660                 665                 670         
Cys Arg Lys Ala Val Tyr Tyr Thr Gly Asn Ser Gly Ala Glu Ala Ala
        675                 680                 685             
Met Asn Trp Val Met Ser His Met Asp Asp Pro Asp Phe Ala Asn Pro
    690                 695                 700                 
Leu Ile Leu Pro Gly Ser Ser Gly Pro Gly Ser Thr Ser Ala Ala Ala
705                 710                 715                 720 
Asp Pro Pro Pro Glu Asp Cys Val Thr Thr Ile Val Ser Met Gly Phe
                725                 730                 735     
Ser Arg Asp Gln Ala Leu Lys Ala Leu Arg Ala Thr Asn Asn Ser Leu
            740                 745                 750         
Glu Arg Ala Val Asp Trp Ile Phe Ser His Ile Asp Asp Leu Asp Ala
        755                 760                 765             
Glu Ala Ala Met Asp Ile Ser Glu Gly Arg Ser Ala Ala Asp Ser Ile
    770                 775                 780                 
Ser Glu Ser Val Pro Val Gly Pro Lys Val Arg Asp Gly Pro Gly Lys
785                 790                 795                 800 
Tyr Gln Leu Phe Ala Phe Ile Ser His Met Gly Thr Ser Thr Met Cys
                805                 810                 815     
Gly His Tyr Val Cys His Ile Lys Lys Glu Gly Arg Trp Val Ile Tyr
            820                 825                 830         
Asn Asp Gln Lys Val Cys Ala Ser Glu Lys Pro Pro Lys Asp Leu Gly
        835                 840                 845             
Tyr Ile Tyr Phe Tyr Gln Arg Val Ala Ser
    850                 855             


<210> 2274
<211> 148
<212> PRT
<213> Homo sapiens

<400> 2274
Met Gln Val Gly Arg Cys Arg Phe Ser Ile Arg Met Ser Cys Cys Arg
 1               5                  10                  15      
Ser Cys Phe Ser Ser Ser Ile Trp Val Phe Ser Ser Ala Phe Met Ser
            20                  25                  30          
Ser Ser Arg Ser Asp Ser Arg Cys Arg Asn Ser Val Arg Ser Phe Phe
        35                  40                  45              
Leu Phe Arg His Arg Ala Ala Ala Thr Leu Phe Phe Ser Arg Arg Leu
    50                  55                  60                  
Phe Leu Arg Ser Ser Ser Ser Ser Ser Ser Leu Phe Thr Gly Trp Gly
65                  70                  75                  80  
Leu Leu Pro Ser Phe Thr Ser Arg Lys Cys Lys Gly Ala Ile Met Ala
                85                  90                  95      
Pro Arg Leu Arg Met Ser Ala Tyr Phe Ser Ser Ser Thr Val Arg Ala
            100                 105                 110         
Glu Leu Gly Ser Pro Val Arg Gly Pro Ser Pro Gly Arg Glu Pro Val
        115                 120                 125             
Val Thr Glu Gly Ser Gly Ile Cys Pro Gly Ile Ile Ala Gly Gly Val
    130                 135                 140                 
Ala Gly Gln Pro
145             


<210> 2275
<211> 541
<212> PRT
<213> Homo sapiens

<400> 2275
Met Phe Ser Trp Met Gly Arg Gln Ala Gly Gly Arg Glu Arg Ala Gly
 1               5                  10                  15      
Gly Ala Asp Ala Val Gln Thr Val Thr Gly Gly Leu Arg Ser Leu Tyr
            20                  25                  30          
Leu Arg Lys Val Leu Pro Leu Glu Glu Ala Tyr Arg Phe His Glu Phe
        35                  40                  45              
His Ser Pro Ala Leu Glu Asp Ala Asp Phe Glu Asn Lys Pro Met Ile
    50                  55                  60                  
Leu Leu Val Gly Gln Tyr Ser Thr Gly Lys Thr Thr Phe Ile Arg Tyr
65                  70                  75                  80  
Leu Leu Glu Gln Asp Phe Pro Gly Met Arg Ile Gly Pro Glu Pro Thr
                85                  90                  95      
Thr Asp Ser Phe Ile Ala Val Met Tyr Gly Glu Thr Glu Gly Ser Thr
            100                 105                 110         
Pro Gly Asn Ala Leu Val Val Asp Pro Lys Lys Pro Phe Arg Lys Leu
        115                 120                 125             
Ser Arg Phe Gly Asn Ala Phe Leu Asn Arg Phe Met Cys Ser Gln Leu
    130                 135                 140                 
Pro Asn Gln Val Leu Lys Ser Ile Ser Val Ile Asp Ser Pro Gly Ile
145                 150                 155                 160 
Leu Ser Gly Glu Lys Gln Arg Ile Ser Arg Gly Tyr Asp Phe Cys Gln
                165                 170                 175     
Val Leu Gln Trp Phe Ala Glu Arg Val Asp Arg Ile Ile Leu Leu Phe
            180                 185                 190         
Asp Ala His Lys Leu Asp Ile Ser Asp Glu Phe Ser Glu Ala Ile Lys
        195                 200                 205             
Ala Phe Arg Gly Gln Asp Asp Lys Ile Arg Val Val Leu Asn Lys Ala
    210                 215                 220                 
Asp Gln Val Asp Thr Gln Gln Leu Met Arg Val Tyr Gly Ala Leu Met
225                 230                 235                 240 
Trp Ser Leu Gly Lys Val Ile Asn Thr Pro Glu Val Leu Arg Val Tyr
                245                 250                 255     
Ile Gly Ser Phe Trp Ala Gln Pro Leu Gln Asn Thr Asp Asn Arg Arg
            260                 265                 270         
Leu Phe Glu Ala Glu Ala Gln Asp Leu Phe Arg Asp Ile Gln Ser Leu
        275                 280                 285             
Pro Gln Lys Ala Ala Val Arg Lys Leu Asn Asp Leu Ile Lys Arg Ala
    290                 295                 300                 
Arg Leu Ala Lys Val His Ala Tyr Ile Ile Ser Tyr Leu Lys Lys Glu
305                 310                 315                 320 
Met Pro Ser Val Phe Gly Lys Glu Asn Lys Lys Arg Glu Leu Ile Ser
                325                 330                 335     
Arg Leu Pro Glu Ile Tyr Ile Gln Leu Gln Arg Glu Tyr Gln Ile Ser
            340                 345                 350         
Ala Gly Asp Phe Pro Glu Val Lys Ala Met Gln Glu Gln Leu Glu Asn
        355                 360                 365             
Tyr Asp Phe Thr Lys Phe His Ser Leu Lys Pro Lys Leu Ile Glu Ala
    370                 375                 380                 
Val Asp Asn Met Leu Ser Asn Lys Ile Ser Pro Leu Met Asn Leu Ile
385                 390                 395                 400 
Ser Gln Glu Glu Thr Ser Thr Pro Thr Gln Leu Val Gln Gly Gly Ala
                405                 410                 415     
Phe Asp Gly Thr Thr Glu Gly Pro Phe Asn Gln Gly Tyr Gly Glu Gly
            420                 425                 430         
Ala Lys Glu Gly Ala Asp Glu Glu Glu Trp Val Val Ala Lys Asp Lys
        435                 440                 445             
Pro Val Tyr Asp Glu Leu Phe Tyr Thr Leu Ser Pro Ile Asn Gly Lys
    450                 455                 460                 
Ile Ser Gly Val Asn Ala Lys Lys Glu Met Val Thr Ser Lys Leu Pro
465                 470                 475                 480 
Asn Ser Val Leu Gly Lys Ile Trp Lys Leu Ala Asp Cys Asp Cys Asp
                485                 490                 495     
Gly Met Leu Asp Glu Glu Glu Phe Ala Leu Ala Lys His Leu Ile Lys
            500                 505                 510         
Ile Lys Leu Asp Gly Tyr Glu Leu Pro Ser Ser Leu Pro Pro His Leu
        515                 520                 525             
Val Pro Pro Ser His Arg Lys Ser Leu Pro Lys Ala Asp
    530                 535                 540     


<210> 2276
<211> 1694
<212> PRT
<213> Homo sapiens

<400> 2276
Met Asp Glu Thr Gly Glu Ile Ser Arg Gly Pro Asp Val His Leu Thr
 1               5                  10                  15      
His Gly Leu Glu Pro Lys Asp Val Asn Arg Glu Phe Arg Leu Thr Glu
            20                  25                  30          
Ser Ser Thr Cys Glu Pro Ser Thr Val Ala Ala Val Leu Ser Arg Ala
        35                  40                  45              
Gln Gly Cys Arg Ser Pro Ser Ala Pro Asp Val Arg Thr Gly Ser Phe
    50                  55                  60                  
Ser His Ser Ala Thr Asp Gly Ser Val Gly Leu Ile Gly Val Pro Glu
65                  70                  75                  80  
Lys Lys Val Ala Glu Lys Gln Ala Ser Thr Glu Leu Glu Ala Ala Ser
                85                  90                  95      
Phe Pro Ala Gly Met Tyr Ser Glu Pro Leu Arg Gln Phe Arg Asp Ser
            100                 105                 110         
Ser Val Gly Asp Gln Asn Ala Gln Val Cys Gln Thr Asn Pro Glu Pro
        115                 120                 125             
Pro Ala Thr Thr Gln Gly Pro His Thr Leu Asp Leu Ser Glu Gly Ser
    130                 135                 140                 
Ala Glu Ser Lys Leu Val Val Glu Pro Gln His Glu Cys Leu Glu Asn
145                 150                 155                 160 
Thr Thr Arg Cys Phe Leu Glu Lys Pro Gln Phe Ser Thr Glu Leu Arg
                165                 170                 175     
Asp His Asn Arg Leu Asp Ser Gln Ala Lys Phe Val Ala Arg Leu Lys
            180                 185                 190         
His Thr Cys Ser Pro Gln Glu Asp Ser Pro Trp Gln Glu Glu Glu Gln
        195                 200                 205             
His Arg Asp Gln Ala Ser Gly Gly Gly Glu Gly Phe Ala Gln Gly Val
    210                 215                 220                 
Asn Pro Leu Pro Asp Glu Asp Gly Leu Asp Gly Cys Gln Ile Leu Asp
225                 230                 235                 240 
Ala Gly Arg Glu Glu Val Ala Val Ala Lys Pro Pro Val Ser Lys Ile
                245                 250                 255     
Leu Ser Gln Gly Phe Lys Asp Pro Ala Thr Val Ser Leu Arg Gln Asn
            260                 265                 270         
Glu Thr Pro Gln Pro Ala Ala Gln Arg Ser Gly His Leu Tyr Thr Gly
        275                 280                 285             
Arg Glu Gln Pro Ala Pro Asn His Arg Gly Ser Leu Pro Val Thr Thr
    290                 295                 300                 
Ile Phe Ser Gly Pro Lys His Ser Arg Ser Ser Pro Thr Pro Gln Phe
305                 310                 315                 320 
Ser Val Val Gly Ser Ser Arg Ser Leu Gln Glu Leu Asn Leu Ser Val
                325                 330                 335     
Glu Pro Pro Ser Pro Thr Asp Glu Asp Thr Gln Gly Pro Asn Arg Leu
            340                 345                 350         
Trp Asn Pro His Leu Arg Gly Tyr Ser Ser Gly Lys Ser Val Ala Arg
        355                 360                 365             
Thr Ser Leu Gln Ala Glu Asp Ser Asn Gln Lys Ala Ser Ser Arg Leu
    370                 375                 380                 
Asp Asp Gly Thr Thr Asp His Arg His Leu Lys Pro Ala Thr Pro Pro
385                 390                 395                 400 
Tyr Pro Met Pro Ser Thr Leu Ser His Met Pro Thr Pro Asp Phe Thr
                405                 410                 415     
Thr Ser Trp Met Ser Gly Thr Leu Glu Gln Ala Gln Gln Gly Lys Arg
            420                 425                 430         
Glu Lys Leu Gly Val Gln Val Arg Pro Glu Asn Trp Cys Ser Gln Met
        435                 440                 445             
Asp Lys Gly Met Leu His Phe Gly Ser Ser Asp Ile Ser Pro Tyr Ala
    450                 455                 460                 
Leu Pro Trp Arg Pro Glu Glu Pro Ala Arg Ile Ser Trp Lys Gln Tyr
465                 470                 475                 480 
Met Ser Gly Ser Ala Val Asp Val Ser Cys Ser Gln Lys Pro Gln Gly
                485                 490                 495     
Leu Thr Leu Ser Asn Val Ala Arg Cys Ser Ser Met Asp Asn Gly Leu
            500                 505                 510         
Glu Asp Gln Asn Ser Pro Phe His Ser His Leu Ser Thr Tyr Ala Asn
        515                 520                 525             
Ile Cys Asp Leu Ser Thr Thr His Ser Ser Thr Glu Asn Ala Gln Gly
    530                 535                 540                 
Ser Asn Glu Ala Trp Glu Val Phe Arg Gly Ser Ser Ser Ile Ala Leu
545                 550                 555                 560 
Gly Asp Pro His Ile Pro Thr Ser Pro Glu Gly Val Ala Pro Thr Ser
                565                 570                 575     
Gly His Asp Arg Arg Pro Gln Phe Arg Gly Pro Ser Gly Glu Ala Asp
            580                 585                 590         
Cys Leu Arg Ser Lys Pro Pro Leu Ala Lys Gly Ser Ala Ala Gly Pro
        595                 600                 605             
Val Asp Glu Ile Met Leu Leu Tyr Pro Ser Glu Ala Gly Cys Pro Val
    610                 615                 620                 
Gly Gln Thr Arg Thr Asn Thr Phe Glu Gln Gly Thr Gln Thr Leu Gly
625                 630                 635                 640 
Ser Arg Arg His Trp Ser Ser Thr Asp Ile Ser Phe Ala Gln Pro Glu
                645                 650                 655     
Ala Ser Ala Val Ser Ala Phe Asp Leu Ala Ser Trp Thr Ser Met His
            660                 665                 670         
Asn Leu Ser Leu His Leu Ser Gln Leu Leu His Ser Thr Ser Glu Leu
        675                 680                 685             
Leu Gly Ser Leu Ser Gln Pro Asp Val Ala Arg Arg Glu Gln Asn Thr
    690                 695                 700                 
Lys Arg Asp Ile Pro Asp Lys Ala Pro Gln Ala Leu Met Met Asp Gly
705                 710                 715                 720 
Ser Thr Gln Thr Thr Val Asp Glu Gly Ser Gln Thr Asp Leu Thr Leu
                725                 730                 735     
Pro Thr Leu Cys Leu Gln Thr Ser Glu Ala Glu Pro Gln Gly Ala Asn
            740                 745                 750         
Val Ile Leu Glu Gly Leu Gly Ser Asp Thr Ser Thr Val Ser Gln Glu
        755                 760                 765             
Glu Gly Asp Val Pro Gly Val Pro Gln Lys Arg Glu Ala Glu Glu Thr
    770                 775                 780                 
Ala Gln Lys Met Ala Gln Leu Leu Tyr Leu Gln Glu Glu Ser Thr Pro
785                 790                 795                 800 
Tyr Lys Pro Gln Ser Pro Ser Ile Pro Ser Ser His Leu Arg Phe Gln
                805                 810                 815     
Lys Ala Pro Val Gly Gln His Leu Pro Ser Val Ser Pro Ser Val Ser
            820                 825                 830         
Asp Ala Phe Leu Pro Pro Ser Ser Gln Pro Glu Glu Ser Tyr Cys Leu
        835                 840                 845             
Val Val Ser Ser Pro Ser Pro Ser Ser Pro His Ser Pro Gly Leu Phe
    850                 855                 860                 
Pro Ser Thr Ser Glu Tyr Pro Gly Asp Ser Arg Val Gln Lys Lys Leu
865                 870                 875                 880 
Gly Pro Thr Ser Ala Leu Phe Val Asp Arg Ala Ser Ser Pro Ile Leu
                885                 890                 895     
Thr Leu Ser Ala Ser Thr Gln Glu Pro Gly Leu Ser Pro Gly Ser Leu
            900                 905                 910         
Thr Leu Ser Ala Pro Ser Thr His Pro Val Glu Gly His Gln Lys Leu
        915                 920                 925             
Asp Ser Ser Pro Asp Pro Val Asp Ala Pro Arg Thr Pro Met Asp Asn
    930                 935                 940                 
Tyr Ser Gln Thr Thr Asp Glu Leu Gly Gly Ser Gln Arg Gly Arg Ser
945                 950                 955                 960 
Ser Leu Gln Arg Ser Asn Gly Arg Ser Phe Leu Glu Leu His Ser Pro
                965                 970                 975     
His Ser Pro Gln Gln Ser Pro Lys Leu Gln Phe Ser Phe Leu Gly Gln
            980                 985                 990         
His Pro Gln Gln Leu Gln Pro Arg Thr Thr Ile Gly Val Gln Ser Arg
        995                 1000                1005            
Leu Leu Pro Pro Pro Leu Arg His Arg Ser Gln Arg Leu Gly Asn Ser
    1010                1015                1020                
Phe Val Pro Glu Lys Val Ala Ser Pro Glu His Cys Pro Leu Ser Gly
1025                1030                1035                1040
Arg Glu Pro Ser Gln Trp Gln Ser Arg Thr Glu Asn Gly Gly Glu Ser
                1045                1050                1055    
Ser Ala Ser Pro Gly Glu Pro Gln Arg Thr Leu Asp Arg Pro Ser Ser
            1060                1065                1070        
Trp Gly Gly Leu Gln His Leu Ser Pro Cys Pro Val Ser Glu Leu Thr
        1075                1080                1085            
Asp Thr Ala Gly Leu Arg Gly Ser Ala Leu Gly Leu Pro Gln Ala Cys
    1090                1095                1100                
Gln Pro Glu Glu Leu Leu Cys Phe Ser Cys Gln Met Cys Met Ala Pro
1105                1110                1115                1120
Glu His Gln His His Ser Leu Arg Asp Leu Pro Val His Asn Lys Phe
                1125                1130                1135    
Ser Asn Trp Cys Gly Val Gln Lys Gly Ser Pro Gly Gly Leu Asp Met
            1140                1145                1150        
Thr Glu Glu Glu Leu Gly Ala Ser Gly Asp Leu Ser Ser Glu Lys Gln
        1155                1160                1165            
Glu Gln Ser Pro Pro Gln Pro Pro Asn Asp His Ser Gln Asp Ser Glu
    1170                1175                1180                
Trp Ser Lys Arg Glu Gln Ile Pro Leu Gln Val Gly Ala Gln Asn Leu
1185                1190                1195                1200
Ser Leu Ser Val Glu Leu Thr Glu Ala Lys Leu His His Gly Phe Gly
                1205                1210                1215    
Glu Ala Asp Ala Leu Leu Gln Val Leu Gln Ser Gly Thr Gly Glu Ala
            1220                1225                1230        
Leu Ala Ala Asp Glu Pro Val Thr Ser Thr Trp Lys Glu Leu Tyr Ala
        1235                1240                1245            
Arg Gln Lys Lys Ala Ile Glu Thr Leu Arg Arg Glu Arg Ala Glu Arg
    1250                1255                1260                
Leu Gly Asn Phe Cys Arg Thr Arg Ser Leu Ser Pro Gln Lys Gln Leu
1265                1270                1275                1280
Ser Leu Leu Pro Asn Lys Asp Leu Phe Ile Trp Asp Leu Asp Leu Pro
                1285                1290                1295    
Ser Arg Arg Arg Glu Tyr Leu Gln Gln Leu Arg Lys Asp Val Val Glu
            1300                1305                1310        
Thr Thr Arg Ser Pro Glu Ser Val Ser Arg Ser Ala His Thr Pro Ser
        1315                1320                1325            
Asp Ile Glu Leu Met Leu Gln Asp Tyr Gln Gln Ala His Glu Glu Ala
    1330                1335                1340                
Lys Val Glu Ile Ala Arg Ala Arg Asp Gln Leu Arg Glu Arg Thr Glu
1345                1350                1355                1360
Gln Glu Lys Leu Arg Ile His Gln Lys Ile Ile Ser Gln Leu Leu Lys
                1365                1370                1375    
Glu Glu Asp Lys Leu His Thr Leu Ala Asn Ser Ser Ser Leu Cys Thr
            1380                1385                1390        
Ser Ser Asn Gly Ser Leu Ser Ser Gly Met Thr Ser Gly Tyr Asn Ser
        1395                1400                1405            
Ser Pro Ala Leu Ser Gly Gln Leu Gln Phe Pro Glu Asn Met Gly His
    1410                1415                1420                
Thr Asn Leu Pro Asp Ser Arg Asp Val Trp Ile Gly Asp Glu Arg Gly
1425                1430                1435                1440
Gly His Ser Ala Val Arg Lys Asn Ser Ala Tyr Ser His Arg Ala Ser
                1445                1450                1455    
Leu Gly Ser Cys Cys Cys Ser Pro Ser Ser Leu Ser Ser Leu Gly Thr
            1460                1465                1470        
Cys Phe Ser Ser Ser Tyr Gln Asp Leu Ala Lys His Val Val Asp Thr
        1475                1480                1485            
Ser Met Ala Asp Val Met Ala Ala Cys Ser Asp Asn Leu His Asn Leu
    1490                1495                1500                
Phe Ser Cys Gln Ala Thr Ala Gly Trp Asn Tyr Gln Gly Glu Glu Gln
1505                1510                1515                1520
Ala Val Gln Leu Tyr Tyr Lys Val Phe Ser Pro Thr Arg His Gly Phe
                1525                1530                1535    
Leu Gly Ala Gly Val Val Ser Gln Pro Leu Ser Arg Val Trp Ala Ala
            1540                1545                1550        
Val Ser Asp Pro Thr Val Trp Pro Leu Tyr Tyr Lys Pro Ile Gln Thr
        1555                1560                1565            
Ala Arg Leu His Gln Arg Val Thr Asn Ser Ile Ser Leu Val Tyr Leu
    1570                1575                1580                
Val Cys Asn Thr Thr Leu Cys Ala Leu Lys Gln Pro Arg Asp Phe Cys
1585                1590                1595                1600
Cys Val Cys Val Glu Ala Lys Glu Gly His Leu Ser Val Met Ala Ala
                1605                1610                1615    
Gln Ser Val Tyr Asp Thr Ser Met Pro Arg Pro Ser Arg Lys Met Val
            1620                1625                1630        
Arg Gly Glu Ile Leu Pro Ser Ala Trp Ile Leu Gln Pro Ile Thr Val
        1635                1640                1645            
Glu Gly Lys Glu Val Thr Arg Val Ile Tyr Leu Ala Gln Val Glu Leu
    1650                1655                1660                
Gly Ala Pro Gly Phe Pro Pro Gln Leu Leu Ser Ser Phe Ile Lys Arg
1665                1670                1675                1680
Gln Pro Leu Val Ile Ala Arg Leu Ala Ser Phe Leu Gly Arg
                1685                1690                


<210> 2277
<211> 289
<212> PRT
<213> Homo sapiens

<400> 2277
Met Met Arg Gln Arg Ala Gln Glu Arg Lys Asn Glu Glu Met Glu Val
 1               5                  10                  15      
Met Glu Val Glu Asp Glu Gly Arg Ser Gly Glu Glu Ser Glu Ser Glu
            20                  25                  30          
Ser Glu Tyr Glu Glu Tyr Thr Asp Ser Glu Asp Glu Met Glu Pro Arg
        35                  40                  45              
Leu Lys Pro Val Phe Ile Arg Lys Lys Asp Arg Val Thr Val Gln Glu
    50                  55                  60                  
Arg Glu Ala Glu Ala Leu Lys Gln Lys Glu Leu Glu Gln Glu Ala Lys
65                  70                  75                  80  
Arg Met Ala Glu Glu Arg Arg Lys Tyr Thr Leu Gln Ile Val Glu Glu
                85                  90                  95      
Glu Thr Lys Lys Glu Leu Glu Glu Asn Lys Arg Ser Leu Ala Ala Leu
            100                 105                 110         
Asp Ala Leu Asn Thr Asp Asp Glu Asn Asp Glu Glu Glu Tyr Glu Ala
        115                 120                 125             
Trp Lys Val Arg Glu Leu Lys Arg Ile Lys Arg Asp Arg Glu Asp Arg
    130                 135                 140                 
Glu Ala Leu Glu Lys Glu Lys Ala Glu Ile Glu Arg Met Arg Asn Leu
145                 150                 155                 160 
Thr Glu Glu Glu Arg Arg Ala Glu Leu Arg Ala Asn Gly Lys Val Ile
                165                 170                 175     
Thr Asn Lys Ala Val Lys Gly Lys Tyr Lys Phe Leu Gln Lys Tyr Tyr
            180                 185                 190         
His Arg Gly Ala Phe Phe Met Asp Glu Asp Glu Glu Val Tyr Lys Arg
        195                 200                 205             
Asp Phe Ser Ala Pro Thr Leu Glu Asp His Phe Asn Lys Thr Ile Leu
    210                 215                 220                 
Pro Lys Val Met Gln Val Lys Asn Phe Gly Arg Ser Gly Arg Thr Lys
225                 230                 235                 240 
Tyr Thr His Leu Val Asp Gln Asp Thr Thr Ser Phe Asp Ser Ala Trp
                245                 250                 255     
Gly Gln Glu Ser Ala Gln Asn Thr Lys Phe Phe Lys Gln Lys Ala Ala
            260                 265                 270         
Gly Val Arg Asp Val Phe Glu Arg Pro Ser Ala Lys Lys Arg Lys Thr
        275                 280                 285             
Thr
    


<210> 2278
<211> 533
<212> PRT
<213> Homo sapiens

<400> 2278
Met Pro Ser Cys Gly Ala Cys Thr Cys Gly Ala Ala Ala Val Arg Leu
 1               5                  10                  15      
Ile Thr Ser Ser Leu Ala Ser Ala Gln Arg Gly Ile Ser Gly Gly Arg
            20                  25                  30          
Ile His Met Ser Val Leu Gly Arg Leu Gly Thr Phe Glu Thr Gln Ile
        35                  40                  45              
Leu Gln Arg Ala Pro Leu Arg Ser Phe Thr Glu Thr Pro Ala Tyr Phe
    50                  55                  60                  
Ala Ser Lys Asp Gly Ile Ser Lys Asp Gly Ser Gly Asp Gly Asn Lys
65                  70                  75                  80  
Lys Ser Ala Ser Glu Gly Ser Ser Lys Lys Ser Gly Ser Gly Asn Ser
                85                  90                  95      
Gly Lys Gly Gly Asn Gln Leu Arg Cys Pro Lys Cys Gly Asp Leu Cys
            100                 105                 110         
Thr His Val Glu Thr Phe Val Ser Ser Thr Arg Phe Val Lys Cys Glu
        115                 120                 125             
Lys Cys His His Phe Phe Val Val Leu Ser Glu Ala Asp Ser Lys Lys
    130                 135                 140                 
Ser Ile Ile Lys Glu Pro Glu Ser Ala Ala Glu Ala Val Lys Leu Ala
145                 150                 155                 160 
Phe Gln Gln Lys Pro Pro Pro Pro Pro Lys Lys Ile Tyr Asn Tyr Leu
                165                 170                 175     
Asp Lys Tyr Val Val Gly Gln Ser Phe Ala Lys Lys Val Leu Ser Val
            180                 185                 190         
Ala Val Tyr Asn His Tyr Lys Arg Ile Tyr Asn Asn Ile Pro Ala Asn
        195                 200                 205             
Leu Arg Gln Gln Ala Glu Val Glu Lys Gln Thr Ser Leu Thr Pro Arg
    210                 215                 220                 
Glu Leu Glu Ile Arg Arg Arg Glu Asp Glu Tyr Arg Phe Thr Lys Leu
225                 230                 235                 240 
Leu Gln Ile Ala Gly Ile Ser Pro His Gly Asn Ala Leu Gly Ala Ser
                245                 250                 255     
Met Gln Gln Gln Val Asn Gln Gln Ile Pro Gln Glu Lys Arg Gly Gly
            260                 265                 270         
Glu Val Leu Asp Ser Ser His Asp Asp Ile Lys Leu Glu Lys Ser Asn
        275                 280                 285             
Ile Leu Leu Leu Gly Pro Thr Gly Ser Gly Lys Thr Leu Leu Ala Gln
    290                 295                 300                 
Thr Leu Ala Lys Cys Leu Asp Val Pro Phe Ala Ile Cys Asp Cys Thr
305                 310                 315                 320 
Thr Leu Thr Gln Ala Gly Tyr Val Gly Glu Asp Ile Glu Ser Val Ile
                325                 330                 335     
Ala Lys Leu Leu Gln Asp Ala Asn Tyr Asn Val Glu Lys Ala Gln Gln
            340                 345                 350         
Gly Ile Val Phe Leu Asp Glu Val Asp Lys Ile Gly Ser Val Pro Gly
        355                 360                 365             
Ile His Gln Leu Arg Asp Val Gly Gly Glu Gly Val Gln Gln Gly Leu
    370                 375                 380                 
Leu Lys Leu Leu Glu Gly Thr Ile Val Asn Val Pro Glu Lys Asn Ser
385                 390                 395                 400 
Arg Lys Leu Arg Gly Glu Thr Val Gln Val Asp Thr Thr Asn Ile Leu
                405                 410                 415     
Phe Val Ala Ser Gly Ala Phe Asn Gly Leu Asp Arg Ile Ile Ser Arg
            420                 425                 430         
Arg Lys Asn Glu Lys Tyr Leu Gly Phe Gly Thr Pro Ser Asn Leu Gly
        435                 440                 445             
Lys Gly Arg Arg Ala Ala Ala Ala Ala Asp Leu Ala Asn Arg Ser Gly
    450                 455                 460                 
Glu Ser Asn Thr His Gln Asp Ile Glu Glu Lys Asp Arg Leu Leu Arg
465                 470                 475                 480 
His Val Glu Ala Arg Asp Leu Ile Glu Phe Gly Met Ile Pro Glu Phe
                485                 490                 495     
Val Gly Arg Leu Pro Val Val Val Pro Leu His Ser Leu Asp Glu Lys
            500                 505                 510         
Thr Leu Val Gln Ile Leu Thr Glu Pro Pro His Pro Ala Leu Phe Thr
        515                 520                 525             
Ile Phe Asn Pro Phe
    530             


<210> 2279
<211> 603
<212> PRT
<213> Homo sapiens

<400> 2279
Met Ser Ala Ala Val Thr Ala Gly Lys Leu Ala Arg Ala Pro Ala Asp
 1               5                  10                  15      
Pro Gly Lys Ala Gly Val Pro Gly Val Ala Ala Pro Gly Ala Pro Ala
            20                  25                  30          
Ala Ala Pro Pro Ala Lys Glu Ile Pro Glu Val Leu Val Asp Pro Arg
        35                  40                  45              
Ser Arg Arg Arg Tyr Val Arg Gly Arg Phe Leu Gly Lys Gly Gly Phe
    50                  55                  60                  
Ala Lys Cys Phe Glu Ile Ser Asp Ala Asp Thr Lys Glu Val Phe Ala
65                  70                  75                  80  
Gly Lys Ile Val Pro Lys Ser Leu Leu Leu Lys Pro His Gln Arg Glu
                85                  90                  95      
Lys Met Ser Met Glu Ile Ser Ile His Arg Ser Leu Ala His Gln His
            100                 105                 110         
Val Val Gly Phe His Gly Phe Phe Glu Asp Asn Asp Phe Val Phe Val
        115                 120                 125             
Val Leu Glu Leu Cys Arg Arg Arg Ser Leu Leu Glu Leu His Lys Arg
    130                 135                 140                 
Arg Lys Ala Leu Thr Glu Pro Glu Ala Arg Tyr Tyr Leu Arg Gln Ile
145                 150                 155                 160 
Val Leu Gly Cys Gln Tyr Leu His Arg Asn Arg Val Ile His Arg Asp
                165                 170                 175     
Leu Lys Leu Gly Asn Leu Phe Leu Asn Glu Asp Leu Glu Val Lys Ile
            180                 185                 190         
Gly Asp Phe Gly Leu Ala Thr Lys Val Glu Tyr Asp Gly Glu Arg Lys
        195                 200                 205             
Lys Thr Leu Cys Gly Thr Pro Asn Tyr Ile Ala Pro Glu Val Leu Ser
    210                 215                 220                 
Lys Lys Gly His Ser Phe Glu Val Asp Val Trp Ser Ile Gly Cys Ile
225                 230                 235                 240 
Met Tyr Thr Leu Leu Val Gly Lys Pro Pro Phe Glu Thr Ser Cys Leu
                245                 250                 255     
Lys Glu Thr Tyr Leu Arg Ile Lys Lys Asn Glu Tyr Ser Ile Pro Lys
            260                 265                 270         
His Ile Asn Pro Val Ala Ala Ser Leu Ile Gln Lys Met Leu Gln Thr
        275                 280                 285             
Asp Pro Thr Ala Arg Pro Thr Ile Asn Glu Leu Leu Asn Asp Glu Phe
    290                 295                 300                 
Phe Thr Ser Gly Tyr Ile Pro Ala Arg Leu Pro Ile Thr Cys Leu Thr
305                 310                 315                 320 
Ile Pro Pro Arg Phe Ser Ile Ala Pro Ser Ser Leu Asp Pro Ser Asn
                325                 330                 335     
Arg Lys Pro Leu Thr Val Leu Asn Lys Gly Leu Glu Asn Pro Leu Pro
            340                 345                 350         
Glu Arg Pro Arg Glu Lys Glu Glu Pro Val Val Arg Glu Thr Gly Glu
        355                 360                 365             
Val Val Asp Cys His Leu Ser Asp Met Leu Gln Gln Leu His Ser Val
    370                 375                 380                 
Asn Ala Ser Lys Pro Ser Glu Arg Gly Leu Val Arg Gln Glu Glu Ala
385                 390                 395                 400 
Glu Asp Pro Ala Cys Ile Pro Ile Phe Trp Val Ser Lys Trp Val Asp
                405                 410                 415     
Tyr Ser Asp Lys Tyr Gly Leu Gly Tyr Gln Leu Cys Asp Asn Ser Val
            420                 425                 430         
Gly Val Leu Phe Asn Asp Ser Thr Arg Leu Ile Leu Tyr Asn Asp Gly
        435                 440                 445             
Asp Ser Leu Gln Tyr Ile Glu Arg Asp Gly Thr Glu Ser Tyr Leu Thr
    450                 455                 460                 
Val Ser Ser His Pro Asn Ser Leu Met Lys Lys Ile Thr Leu Leu Lys
465                 470                 475                 480 
Tyr Phe Arg Asn Tyr Met Ser Glu His Leu Leu Lys Ala Gly Ala Asn
                485                 490                 495     
Ile Thr Pro Arg Glu Gly Asp Glu Leu Ala Arg Leu Pro Tyr Leu Arg
            500                 505                 510         
Thr Trp Phe Arg Thr Arg Ser Ala Ile Ile Leu His Leu Ser Asn Gly
        515                 520                 525             
Ser Val Gln Ile Asn Phe Phe Gln Asp His Thr Lys Leu Ile Leu Cys
    530                 535                 540                 
Pro Leu Met Ala Ala Val Thr Tyr Ile Asp Glu Lys Arg Asp Phe Arg
545                 550                 555                 560 
Thr Tyr Arg Leu Ser Leu Leu Glu Glu Tyr Gly Cys Cys Lys Glu Leu
                565                 570                 575     
Ala Ser Arg Leu Arg Tyr Ala Arg Thr Met Val Asp Lys Leu Leu Ser
            580                 585                 590         
Ser Arg Ser Ala Ser Asn Arg Leu Lys Ala Ser
        595                 600             


<210> 2280
<211> 912
<212> PRT
<213> Homo sapiens

<400> 2280
Met Tyr Phe Ala Trp Leu Gly Phe Tyr Thr Ser Ala Met Val Tyr Pro
 1               5                  10                  15      
Ala Val Phe Gly Ser Val Leu Tyr Thr Phe Thr Glu Ala Asp Gln Thr
            20                  25                  30          
Ser Arg Asp Val Ser Cys Val Val Phe Ala Leu Phe Asn Val Ile Trp
        35                  40                  45              
Ser Thr Leu Phe Leu Glu Glu Trp Lys Arg Arg Gly Ala Glu Leu Ala
    50                  55                  60                  
Tyr Lys Trp Gly Thr Leu Asp Ser Pro Gly Glu Ala Val Glu Glu Pro
65                  70                  75                  80  
Arg Pro Gln Phe Arg Gly Val Arg Arg Ile Ser Pro Ile Thr Arg Ala
                85                  90                  95      
Glu Glu Phe Tyr Tyr Pro Pro Trp Lys Arg Leu Leu Phe Gln Leu Leu
            100                 105                 110         
Val Ser Leu Pro Leu Cys Leu Ala Cys Leu Val Cys Val Phe Leu Leu
        115                 120                 125             
Met Leu Gly Cys Phe Gln Leu Gln Glu Leu Val Leu Ser Val Lys Gly
    130                 135                 140                 
Leu Pro Arg Leu Ala Arg Phe Leu Pro Lys Val Met Leu Ala Leu Leu
145                 150                 155                 160 
Val Ser Val Ser Ala Glu Gly Tyr Lys Lys Leu Ala Ile Trp Leu Asn
                165                 170                 175     
Asp Met Glu Asn Tyr Arg Leu Glu Ser Ala Tyr Glu Lys His Leu Ile
            180                 185                 190         
Ile Lys Val Val Leu Phe Gln Phe Val Asn Ser Tyr Leu Ser Leu Phe
        195                 200                 205             
Tyr Ile Gly Phe Tyr Leu Lys Asp Met Glu Arg Leu Lys Glu Leu Leu
    210                 215                 220                 
Leu Val Leu Ser Leu Ser Gln Ser Leu Glu Arg Gln Leu Gln Ala Val
225                 230                 235                 240 
Leu Val Pro Leu Ala Ala Leu Arg Phe Arg Leu Leu Leu Leu Ser Leu
                245                 250                 255     
Arg Gly Leu Leu Leu Ala Ala Arg Ala Lys Met Leu Ala Thr Leu Leu
            260                 265                 270         
Ile Thr Arg Gln Phe Leu Gln Asn Val Arg Glu Val Leu Gln Pro His
        275                 280                 285             
Leu Tyr Arg Arg Leu Gly Arg Gly Glu Leu Gly Leu Arg Ala Val Trp
    290                 295                 300                 
Glu Leu Ala Arg Ala Leu Leu Gly Leu Leu Ser Leu Arg Arg Pro Ala
305                 310                 315                 320 
Pro Arg Arg Leu Glu Pro Gln Ala Asp Glu Gly Gly Gly Gly Gly Ser
                325                 330                 335     
Gly Gly Gly Gly Arg Arg Cys Leu Ser Gly Gly Cys Gly Ala Pro Glu
            340                 345                 350         
Glu Glu Glu Glu Ala Ala Leu Val Glu Arg Arg Arg Ala Gly Glu Gly
        355                 360                 365             
Gly Glu Glu Gly Asp Gly Pro Pro Gly Gly Lys Glu Glu Asp Glu Asp
    370                 375                 380                 
Asp Glu Glu Glu Glu Asp Glu Glu Glu Glu Glu Asp Glu Glu Glu Gly
385                 390                 395                 400 
Glu Glu Gly Gly Leu Leu Asp Cys Gly Leu Arg Leu Lys Lys Val Ser
                405                 410                 415     
Phe Ala Glu Arg Gly Ala Gly Arg Arg Arg Pro Gly Pro Ser Pro Glu
            420                 425                 430         
Ala Leu Leu Glu Glu Gly Ser Pro Thr Met Val Glu Lys Gly Leu Glu
        435                 440                 445             
Pro Gly Val Phe Thr Leu Ala Glu Glu Asp Asp Glu Ala Glu Gly Ala
    450                 455                 460                 
Pro Gly Ser Pro Glu Arg Glu Pro Pro Ala Ile Leu Phe Arg Arg Ala
465                 470                 475                 480 
Gly Gly Glu Gly Arg Asp Gln Gly Pro Asp Gly Gly Pro Asp Pro Glu
                485                 490                 495     
Pro Gly Ser Asn Ser Asp Ser Thr Arg Arg Gln Arg Arg Gln Asn Arg
            500                 505                 510         
Ser Ser Trp Ile Asp Pro Pro Glu Glu Glu His Ser Pro Gln Leu Thr
        515                 520                 525             
Gln Ala Glu Leu Glu Ser Cys Met Lys Lys Tyr Glu Asp Thr Phe Gln
    530                 535                 540                 
Asp Tyr Gln Glu Met Phe Val Gln Phe Gly Tyr Val Val Leu Phe Ser
545                 550                 555                 560 
Ser Ala Phe Pro Leu Ala Ala Leu Cys Ala Leu Val Asn Asn Leu Ile
                565                 570                 575     
Glu Ile Arg Ser Asp Ala Phe Lys Leu Cys Thr Gly Leu Gln Arg Pro
            580                 585                 590         
Phe Gly Gln Arg Val Glu Ser Ile Gly Gln Trp Gln Lys Val Met Glu
        595                 600                 605             
Ala Met Gly Val Leu Ala Ile Val Val Asn Cys Tyr Leu Ile Gly Gln
    610                 615                 620                 
Cys Gly Gln Leu Gln Arg Leu Phe Pro Trp Leu Ser Pro Glu Ala Ala
625                 630                 635                 640 
Ile Val Ser Val Val Val Leu Glu His Phe Ala Leu Leu Leu Lys Tyr
                645                 650                 655     
Leu Ile His Val Ala Ile Pro Asp Ile Pro Gly Trp Val Ala Glu Glu
            660                 665                 670         
Met Ala Lys Leu Glu Tyr Gln Arg Arg Glu Ala Phe Lys Arg His Glu
        675                 680                 685             
Arg Gln Ala Gln His Arg Tyr Gln Gln Gln Gln Arg Arg Arg Arg Glu
    690                 695                 700                 
Glu Glu Glu Arg Gln Arg His Ala Glu His His Ala Arg Arg Glu His
705                 710                 715                 720 
Asp Ser Gly Gly Arg Glu Glu Ala Arg Ala Glu Gly Ser Gly Leu Asp
                725                 730                 735     
Pro Ala Thr Ser Ser Glu Lys Ala Ser Ala Lys Ala Lys Gly Ser Thr
            740                 745                 750         
Ala Gly Gly His Gly Pro Glu Arg Pro Lys Arg Pro Gly Ser Leu Leu
        755                 760                 765             
Ala Pro Asn Asn Val Met Lys Leu Lys Gln Ile Ile Pro Leu Gln Gly
    770                 775                 780                 
Lys Phe Leu Ser Ser Gly Ala Thr Ser Ser Leu Ala Ala Ala Gly Ala
785                 790                 795                 800 
Gly Ala Thr Thr Arg Pro Pro Pro Ala Gln Ser Pro Thr Gly Ser Asp
                805                 810                 815     
Thr Arg Leu Pro Ala Phe Leu Ser Phe Lys Phe Leu Lys Ser Pro Glu
            820                 825                 830         
Thr Arg Arg Asp Ser Glu Arg Ser His Ser Pro Pro Lys Ala Phe His
        835                 840                 845             
Ala Gly Lys Leu Phe Pro Phe Gly Gly Thr Arg Ala Glu Pro Gly Ser
    850                 855                 860                 
Asn Gly Ala Gly Gly Gln Ala Arg Pro Asp Gly Thr Pro Ser Ser Gly
865                 870                 875                 880 
Ser Ser Arg Val Gln Arg Ser Gly Pro Val Asp Glu Ala Leu Ala Glu
                885                 890                 895     
Glu Leu Glu Ala Pro Arg Pro Glu Glu Glu Gly Ser Gly His Lys Leu
            900                 905                 910         


<210> 2281
<211> 224
<212> PRT
<213> Homo sapiens

<400> 2281
Met Ala Val Phe Ile Ile Leu Ser Leu Phe Ser Val Leu Val Thr Gly
 1               5                  10                  15      
Met Gly Glu Gly Gly Ala Gly Ser Glu Lys Gly Gly Glu Arg Glu Cys
            20                  25                  30          
Lys Leu Asn Gln Leu Pro His Cys Pro Ser Val Ser Pro Ser Ala Gln
        35                  40                  45              
Pro Trp Thr His Pro Gly Gln Ser Gln Leu Phe Ala Asp Leu Ser Arg
    50                  55                  60                  
Glu Glu Leu Thr Ala Val Met Arg Phe Leu Thr Gln Gln Leu Gly Pro
65                  70                  75                  80  
Gly Leu Val Asp Ala Ala Gln Ala Gln Pro Ser Asp Asn Cys Val Phe
                85                  90                  95      
Ser Val Glu Leu Gln Leu Pro Pro Lys Ala Ala Ala Leu Ala His Leu
            100                 105                 110         
Asp Arg Gly Ser Pro Pro Pro Ala Arg Glu Ala Leu Ala Ile Val Phe
        115                 120                 125             
Phe Gly Arg Gln Pro Gln Pro Asn Val Ser Glu Leu Val Val Gly Pro
    130                 135                 140                 
Leu Pro His Pro Ser Tyr Met Arg Asp Val Thr Val Glu Arg His Gly
145                 150                 155                 160 
Gly Pro Leu Pro Tyr His Arg Arg Pro Met Leu Phe Gln Glu Tyr Leu
                165                 170                 175     
Asp Ile Asp Gln Met Ile Phe Asp Arg Glu Leu Pro Gln Ala Ser Gly
            180                 185                 190         
Leu Leu His His Cys Cys Phe Tyr Lys Arg Arg Gly Arg Asn Leu Val
        195                 200                 205             
Thr Met Thr Thr Ala Pro Arg Gly Leu Gln Ser Gly Asp Arg Ala Thr
    210                 215                 220                 


<210> 2282
<211> 1415
<212> PRT
<213> Homo sapiens

<400> 2282
Met Ser Gly Leu Gly Glu Asn Leu Asp Pro Leu Ala Ser Asp Ser Arg
 1               5                  10                  15      
Lys Arg Lys Leu Pro Cys Asp Thr Pro Gly Gln Gly Leu Thr Cys Ser
            20                  25                  30          
Gly Glu Lys Arg Arg Arg Glu Gln Glu Ser Lys Tyr Ile Glu Glu Leu
        35                  40                  45              
Ala Glu Leu Ile Ser Ala Asn Leu Ser Asp Ile Asp Asn Phe Asn Val
    50                  55                  60                  
Lys Pro Asp Lys Cys Ala Ile Leu Lys Glu Thr Val Arg Gln Ile Arg
65                  70                  75                  80  
Gln Ile Lys Glu Gln Gly Lys Thr Ile Ser Asn Asp Asp Asp Val Gln
                85                  90                  95      
Lys Ala Asp Val Ser Ser Thr Gly Gln Gly Val Ile Asp Lys Asp Ser
            100                 105                 110         
Leu Gly Pro Leu Leu Leu Gln Ala Leu Asp Gly Phe Leu Phe Val Val
        115                 120                 125             
Asn Arg Asp Gly Asn Ile Val Phe Val Ser Glu Asn Val Thr Gln Tyr
    130                 135                 140                 
Leu Gln Tyr Lys Gln Glu Asp Leu Val Asn Thr Ser Val Tyr Asn Ile
145                 150                 155                 160 
Leu His Glu Glu Asp Arg Lys Asp Phe Leu Lys Asn Leu Pro Lys Ser
                165                 170                 175     
Thr Val Asn Gly Val Ser Trp Thr Asn Glu Thr Gln Arg Gln Lys Ser
            180                 185                 190         
His Thr Phe Asn Cys Arg Met Leu Met Lys Thr Pro His Asp Ile Leu
        195                 200                 205             
Glu Asp Ile Asn Ala Ser Pro Glu Met Arg Gln Arg Tyr Glu Thr Met
    210                 215                 220                 
Gln Cys Phe Ala Leu Ser Gln Pro Arg Ala Met Met Glu Glu Gly Glu
225                 230                 235                 240 
Asp Leu Gln Ser Cys Met Ile Cys Val Ala Arg Arg Ile Thr Thr Gly
                245                 250                 255     
Glu Arg Thr Phe Pro Ser Asn Pro Glu Ser Phe Ile Thr Arg His Asp
            260                 265                 270         
Leu Ser Gly Lys Val Val Asn Ile Asp Thr Asn Ser Leu Arg Ser Ser
        275                 280                 285             
Met Arg Pro Gly Phe Glu Asp Ile Ile Arg Arg Cys Ile Gln Arg Phe
    290                 295                 300                 
Phe Ser Leu Asn Asp Gly Gln Ser Trp Ser Gln Lys Arg His Tyr Gln
305                 310                 315                 320 
Glu Val Thr Ser Asp Gly Ile Phe Ser Pro Thr Ala Tyr Leu Asn Gly
                325                 330                 335     
His Ala Glu Thr Pro Val Tyr Arg Phe Ser Leu Ala Asp Gly Thr Ile
            340                 345                 350         
Val Thr Ala Gln Thr Lys Ser Lys Leu Phe Arg Asn Pro Val Thr Asn
        355                 360                 365             
Asp Arg His Gly Phe Val Ser Thr His Phe Leu Gln Arg Glu Gln Asn
    370                 375                 380                 
Gly Tyr Arg Pro Asn Pro Asn Pro Val Gly Gln Gly Ile Arg Pro Pro
385                 390                 395                 400 
Met Ala Gly Cys Asn Ser Ser Val Gly Gly Met Ser Met Ser Pro Asn
                405                 410                 415     
Gln Gly Leu Gln Met Pro Ser Ser Arg Ala Tyr Gly Leu Ala Asp Pro
            420                 425                 430         
Ser Thr Thr Gly Gln Met Ser Gly Ala Arg Tyr Gly Gly Ser Ser Asn
        435                 440                 445             
Ile Ala Ser Leu Thr Pro Gly Pro Gly Met Gln Ser Pro Ser Ser Tyr
    450                 455                 460                 
Gln Asn Asn Asn Tyr Gly Leu Asn Met Ser Ser Pro Pro His Gly Ser
465                 470                 475                 480 
Pro Gly Leu Ala Pro Asn Gln Gln Asn Ile Met Ile Ser Pro Arg Asn
                485                 490                 495     
Arg Gly Ser Pro Lys Ile Ala Ser His Gln Phe Ser Pro Val Ala Gly
            500                 505                 510         
Val His Ser Pro Met Ala Ser Ser Gly Asn Thr Gly Asn His Ser Phe
        515                 520                 525             
Ser Ser Ser Ser Leu Ser Ala Leu Gln Ala Ile Ser Glu Gly Val Gly
    530                 535                 540                 
Thr Ser Leu Leu Ser Thr Leu Ser Ser Pro Gly Pro Lys Leu Asp Asn
545                 550                 555                 560 
Ser Pro Asn Met Asn Ile Thr Gln Pro Ser Lys Val Ser Asn Gln Asp
                565                 570                 575     
Ser Lys Ser Pro Leu Gly Phe Tyr Cys Asp Gln Asn Pro Val Glu Ser
            580                 585                 590         
Ser Met Cys Gln Ser Asn Ser Arg Asp His Leu Ser Asp Lys Glu Ser
        595                 600                 605             
Lys Glu Ser Ser Val Glu Gly Ala Glu Asn Gln Arg Gly Pro Leu Glu
    610                 615                 620                 
Ser Lys Gly His Lys Lys Leu Leu Gln Leu Leu Thr Cys Ser Ser Asp
625                 630                 635                 640 
Asp Arg Gly His Ser Ser Leu Thr Asn Ser Pro Leu Asp Ser Ser Cys
                645                 650                 655     
Lys Glu Ser Ser Val Ser Val Thr Ser Pro Ser Gly Val Ser Ser Ser
            660                 665                 670         
Thr Ser Gly Gly Val Ser Ser Thr Ser Asn Met His Gly Ser Leu Leu
        675                 680                 685             
Gln Glu Lys His Arg Ile Leu His Lys Leu Leu Gln Asn Gly Asn Ser
    690                 695                 700                 
Pro Ala Glu Val Ala Lys Ile Thr Ala Glu Ala Thr Gly Lys Asp Thr
705                 710                 715                 720 
Ser Ser Ile Thr Ser Cys Gly Asp Gly Asn Val Val Lys Gln Glu Gln
                725                 730                 735     
Leu Ser Pro Lys Lys Lys Glu Asn Asn Ala Leu Leu Arg Tyr Leu Leu
            740                 745                 750         
Asp Arg Asp Asp Pro Ser Asp Ala Leu Ser Lys Glu Leu Gln Pro Gln
        755                 760                 765             
Val Glu Gly Val Asp Asn Lys Met Ser Gln Cys Thr Ser Ser Thr Ile
    770                 775                 780                 
Pro Ser Ser Ser Gln Glu Lys Asp Pro Lys Ile Lys Thr Glu Thr Ser
785                 790                 795                 800 
Glu Glu Gly Ser Gly Asp Leu Asp Asn Leu Asp Ala Ile Leu Gly Asp
                805                 810                 815     
Leu Thr Ser Ser Asp Phe Tyr Asn Asn Ser Ile Ser Ser Asn Gly Ser
            820                 825                 830         
His Leu Gly Thr Lys Gln Gln Val Phe Gln Gly Thr Asn Ser Leu Gly
        835                 840                 845             
Leu Lys Ser Ser Gln Ser Val Gln Ser Ile Arg Pro Pro Tyr Asn Arg
    850                 855                 860                 
Ala Val Ser Leu Asp Ser Pro Val Ser Val Gly Ser Ser Pro Pro Val
865                 870                 875                 880 
Lys Asn Ile Ser Ala Phe Pro Met Leu Pro Lys Gln Pro Met Leu Gly
                885                 890                 895     
Gly Asn Pro Arg Met Met Asp Ser Gln Glu Asn Tyr Gly Ser Ser Met
            900                 905                 910         
Gly Asp Trp Gly Leu Pro Asn Ser Lys Ala Gly Arg Met Glu Pro Met
        915                 920                 925             
Asn Ser Asn Ser Met Gly Arg Pro Gly Gly Asp Tyr Asn Thr Ser Leu
    930                 935                 940                 
Pro Arg Pro Ala Leu Gly Gly Ser Ile Pro Thr Leu Pro Leu Arg Ser
945                 950                 955                 960 
Asn Ser Ile Pro Gly Ala Arg Pro Val Leu Gln Gln Gln Gln Gln Met
                965                 970                 975     
Leu Gln Met Arg Pro Gly Glu Ile Pro Met Gly Met Gly Ala Asn Pro
            980                 985                 990         
Tyr Gly Gln Ala Ala Ala Ser Asn Gln Leu Gly Ser Trp Pro Asp Gly
        995                 1000                1005            
Met Leu Ser Met Glu Gln Val Ser His Gly Thr Gln Asn Arg Pro Leu
    1010                1015                1020                
Leu Arg Asn Ser Leu Asp Asp Leu Val Gly Pro Pro Ser Asn Leu Glu
1025                1030                1035                1040
Gly Gln Ser Asp Glu Arg Ala Leu Leu Asp Gln Leu His Thr Leu Leu
                1045                1050                1055    
Ser Asn Thr Asp Ala Thr Gly Leu Glu Glu Ile Asp Arg Ala Leu Gly
            1060                1065                1070        
Ile Pro Glu Leu Val Asn Gln Gly Gln Ala Leu Glu Pro Lys Gln Asp
        1075                1080                1085            
Ala Phe Gln Gly Gln Glu Ala Ala Val Met Met Asp Gln Lys Ala Gly
    1090                1095                1100                
Leu Tyr Gly Gln Thr Tyr Pro Ala Gln Gly Pro Pro Met Gln Gly Gly
1105                1110                1115                1120
Phe His Leu Gln Gly Gln Ser Pro Ser Phe Asn Ser Met Met Asn Gln
                1125                1130                1135    
Met Asn Gln Gln Gly Asn Phe Pro Leu Gln Gly Met His Pro Arg Ala
            1140                1145                1150        
Asn Ile Met Arg Pro Arg Thr Asn Thr Pro Lys Gln Leu Arg Met Gln
        1155                1160                1165            
Leu Gln Gln Arg Leu Gln Gly Gln Gln Phe Leu Asn Gln Ser Arg Gln
    1170                1175                1180                
Ala Leu Glu Leu Lys Met Glu Asn Pro Thr Ala Gly Gly Ala Ala Val
1185                1190                1195                1200
Met Arg Pro Met Met Gln Pro Gln Gln Gly Phe Leu Asn Ala Gln Met
                1205                1210                1215    
Val Ala Gln Arg Ser Arg Glu Leu Leu Ser His His Phe Arg Gln Gln
            1220                1225                1230        
Arg Val Ala Met Met Met Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
        1235                1240                1245            
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
    1250                1255                1260                
Gln Gln Gln Thr Gln Ala Phe Ser Pro Pro Pro Asn Val Thr Ala Ser
1265                1270                1275                1280
Pro Ser Met Asp Gly Leu Leu Ala Gly Pro Thr Met Pro Gln Ala Pro
                1285                1290                1295    
Pro Gln Gln Phe Pro Tyr Gln Pro Asn Tyr Gly Met Gly Gln Gln Pro
            1300                1305                1310        
Asp Pro Ala Phe Gly Arg Val Ser Ser Pro Pro Asn Ala Met Met Ser
        1315                1320                1325            
Ser Arg Met Gly Pro Ser Gln Asn Pro Met Met Gln His Pro Gln Ala
    1330                1335                1340                
Ala Ser Ile Tyr Gln Ser Ser Glu Met Lys Gly Trp Pro Ser Gly Asn
1345                1350                1355                1360
Leu Ala Arg Asn Ser Ser Phe Ser Gln Gln Gln Phe Ala His Gln Gly
                1365                1370                1375    
Asn Pro Ala Val Tyr Ser Met Val His Met Asn Gly Ser Ser Gly His
            1380                1385                1390        
Met Gly Gln Met Asn Met Asn Pro Met Pro Met Ser Gly Met Pro Met
        1395                1400                1405            
Gly Pro Asp Gln Lys Tyr Cys
    1410                1415


<210> 2283
<211> 372
<212> PRT
<213> Homo sapiens

<400> 2283
Met Asn Arg Ser His Arg His Gly Ala Gly Ser Gly Cys Leu Gly Thr
 1               5                  10                  15      
Met Glu Val Lys Ser Lys Phe Gly Ala Glu Phe Arg Arg Phe Ser Leu
            20                  25                  30          
Glu Arg Ser Lys Pro Gly Lys Phe Glu Glu Phe Tyr Gly Leu Leu Gln
        35                  40                  45              
His Val His Lys Ile Pro Asn Val Asp Val Leu Val Gly Tyr Ala Asp
    50                  55                  60                  
Ile His Gly Asp Leu Leu Pro Ile Asn Asn Asp Asp Asn Tyr His Lys
65                  70                  75                  80  
Ala Val Ser Thr Ala Asn Pro Leu Leu Arg Ile Phe Ile Gln Lys Lys
                85                  90                  95      
Glu Glu Ala Asp Tyr Ser Ala Phe Gly Thr Asp Thr Leu Ile Lys Lys
            100                 105                 110         
Lys Asn Val Leu Thr Asn Val Leu Arg Pro Asp Asn His Arg Lys Lys
        115                 120                 125             
Pro His Ile Val Ile Ser Met Pro Gln Asp Phe Arg Pro Val Ser Ser
    130                 135                 140                 
Ile Ile Asp Val Asp Ile Leu Pro Glu Thr His Arg Arg Val Arg Leu
145                 150                 155                 160 
Tyr Lys Tyr Gly Thr Glu Lys Pro Leu Gly Phe Tyr Ile Arg Asp Gly
                165                 170                 175     
Ser Ser Val Arg Val Thr Pro His Gly Leu Glu Lys Val Pro Gly Ile
            180                 185                 190         
Phe Ile Ser Arg Leu Val Pro Gly Gly Leu Ala Gln Ser Thr Gly Leu
        195                 200                 205             
Leu Ala Val Asn Asp Glu Val Leu Glu Val Asn Gly Ile Glu Val Ser
    210                 215                 220                 
Gly Lys Ser Leu Asp Gln Val Thr Asp Met Met Ile Ala Asn Ser Arg
225                 230                 235                 240 
Asn Leu Ile Ile Thr Val Arg Pro Ala Asn Gln Arg Asn Asn Val Val
                245                 250                 255     
Arg Asn Ser Arg Thr Ser Gly Ser Ser Gly Gln Ser Thr Asp Asn Ser
            260                 265                 270         
Leu Leu Gly Tyr Pro Gln Gln Ile Glu Pro Ser Phe Glu Pro Glu Asp
        275                 280                 285             
Glu Asp Ser Glu Glu Asp Asp Ile Ile Ile Glu Asp Asn Gly Val Pro
    290                 295                 300                 
Gln Gln Ile Pro Lys Ala Val Pro Asn Thr Glu Ser Leu Glu Ser Leu
305                 310                 315                 320 
Thr Gln Ile Glu Leu Ser Phe Glu Ser Gly Gln Asn Gly Phe Ile Pro
                325                 330                 335     
Ser Asn Glu Val Ser Leu Ala Ala Ile Ala Ser Ser Ser Asn Thr Glu
            340                 345                 350         
Phe Glu Thr His Ala Pro Asp Gln Lys Leu Leu Glu Glu Asp Gly Thr
        355                 360                 365             
Ile Ile Thr Leu
    370         


<210> 2284
<211> 514
<212> PRT
<213> Homo sapiens

<400> 2284
Met Ser Ser Pro Ile Ser Lys Ser Arg Ser Leu Ala Ala Phe Leu Gln
 1               5                  10                  15      
Gln Leu Arg Ser Pro Arg Gln Pro Pro Arg Leu Val Thr Ser Thr Ala
            20                  25                  30          
Tyr Thr Ser Pro Gln Pro Arg Glu Val Pro Val Cys Pro Leu Thr Ala
        35                  40                  45              
Gly Gly Glu Thr Gln Asn Ala Ala Ala Leu Pro Gly Pro Thr Ser Trp
    50                  55                  60                  
Pro Leu Leu Gly Ser Leu Leu Gln Ile Leu Trp Lys Gly Gly Leu Lys
65                  70                  75                  80  
Lys Gln His Asp Thr Leu Val Glu Tyr His Lys Lys Tyr Gly Lys Ile
                85                  90                  95      
Phe Arg Met Lys Leu Gly Ser Phe Glu Ser Val His Leu Gly Ser Pro
            100                 105                 110         
Cys Leu Leu Glu Ala Leu Tyr Arg Thr Glu Ser Ala Tyr Pro Gln Arg
        115                 120                 125             
Leu Glu Ile Lys Pro Trp Lys Ala Tyr Arg Asp Tyr Arg Lys Glu Gly
    130                 135                 140                 
Tyr Gly Leu Leu Ile Leu Glu Gly Glu Asp Trp Gln Arg Val Arg Ser
145                 150                 155                 160 
Ala Phe Gln Lys Lys Leu Met Lys Pro Gly Glu Val Met Lys Leu Asp
                165                 170                 175     
Asn Lys Ile Asn Glu Val Leu Ala Asp Phe Met Gly Arg Ile Asp Glu
            180                 185                 190         
Leu Cys Asp Glu Arg Gly His Val Glu Asp Leu Tyr Ser Glu Leu Asn
        195                 200                 205             
Lys Trp Ser Phe Glu Ser Ile Cys Leu Val Leu Tyr Glu Lys Arg Phe
    210                 215                 220                 
Gly Leu Leu Gln Lys Asn Ala Gly Asp Glu Ala Val Asn Phe Ile Met
225                 230                 235                 240 
Ala Ile Lys Thr Met Met Ser Thr Phe Gly Arg Met Met Val Thr Pro
                245                 250                 255     
Val Glu Leu His Lys Ser Leu Asn Thr Lys Val Trp Gln Asp His Thr
            260                 265                 270         
Leu Ala Trp Asp Thr Ile Phe Lys Ser Val Lys Ala Cys Ile Asp Asn
        275                 280                 285             
Arg Leu Glu Lys Tyr Ser Gln Gln Pro Ser Ala Asp Phe Leu Cys Asp
    290                 295                 300                 
Ile Tyr His Gln Asn Arg Leu Ser Lys Lys Glu Leu Tyr Ala Ala Val
305                 310                 315                 320 
Thr Glu Leu Gln Leu Ala Ala Val Glu Thr Thr Ala Asn Ser Leu Met
                325                 330                 335     
Trp Ile Leu Tyr Asn Leu Ser Arg Asn Pro Gln Val Gln Gln Lys Leu
            340                 345                 350         
Leu Lys Glu Ile Gln Ser Val Leu Pro Glu Asn Gln Val Pro Arg Ala
        355                 360                 365             
Glu Asp Leu Arg Asn Met Pro Tyr Leu Lys Ala Cys Leu Lys Glu Ser
    370                 375                 380                 
Met Arg Leu Thr Pro Ser Val Pro Phe Thr Thr Arg Thr Leu Asp Lys
385                 390                 395                 400 
Ala Thr Val Leu Gly Glu Tyr Ala Leu Pro Lys Gly Thr Val Leu Met
                405                 410                 415     
Leu Asn Thr Gln Val Leu Gly Ser Ser Glu Asp Asn Phe Glu Asp Ser
            420                 425                 430         
Ser Gln Phe Arg Pro Glu Arg Trp Leu Gln Glu Lys Glu Lys Ile Asn
        435                 440                 445             
Pro Phe Ala His Leu Pro Phe Gly Val Gly Lys Arg Met Cys Ile Gly
    450                 455                 460                 
Arg Arg Leu Ala Glu Leu Gln Leu His Leu Ala Leu Cys Trp Ile Val
465                 470                 475                 480 
Arg Lys Tyr Asp Ile Gln Ala Thr Asp Asn Glu Pro Val Glu Met Leu
                485                 490                 495     
His Ser Gly Thr Leu Val Pro Ser Arg Glu Leu Pro Ile Ala Phe Cys
            500                 505                 510         
Gln Arg
        


<210> 2285
<211> 825
<212> PRT
<213> Homo sapiens

<400> 2285
Met Glu Gln Leu Pro Gly Val Pro Pro Gly Pro Pro His Pro Val Arg
 1               5                  10                  15      
Pro Pro Pro Pro Pro Pro Pro Pro Met Pro Leu Gln Leu Glu Ala His
            20                  25                  30          
Leu Arg Ser His Gly Leu Glu Pro Ala Ala Pro Ser Pro Arg Leu Arg
        35                  40                  45              
Pro Glu Glu Ser Leu Asp Pro Pro Gly Ala Met Gln Glu Leu Leu Gly
    50                  55                  60                  
Ala Leu Glu Pro Leu Pro Pro Ala Pro Gly Asp Thr Gly Val Gly Pro
65                  70                  75                  80  
Pro Asn Ser Glu Gly Lys Asp Pro Ala Gly Ala Tyr Arg Ser Pro Ser
                85                  90                  95      
Pro Gln Gly Thr Lys Ala Pro Arg Phe Val Pro Leu Thr Ser Ile Cys
            100                 105                 110         
Phe Pro Asp Ser Leu Leu Gln Asp Glu Glu Arg Ser Phe Phe Pro Thr
        115                 120                 125             
Met Glu Glu Met Phe Gly Gly Gly Ala Ala Asp Asp Tyr Gly Lys Ala
    130                 135                 140                 
Gly Pro Pro Glu Asp Glu Gly Asp Pro Lys Ala Gly Ala Gly Pro Pro
145                 150                 155                 160 
Pro Gly Pro Pro Ala Tyr Asp Pro Tyr Gly Pro Tyr Cys Pro Gly Arg
                165                 170                 175     
Ala Ser Gly Ala Gly Pro Glu Thr Pro Gly Leu Gly Leu Asp Pro Asn
            180                 185                 190         
Lys Pro Pro Glu Leu Pro Ser Thr Val Asn Ala Glu Pro Leu Gly Leu
        195                 200                 205             
Ile Gln Ser Gly Pro His Gln Ala Ala Pro Pro Pro Pro Pro Pro Pro
    210                 215                 220                 
Pro Pro Pro Pro Ala Pro Ala Ser Glu Pro Lys Gly Gly Leu Thr Ser
225                 230                 235                 240 
Pro Ile Phe Cys Ser Thr Lys Pro Lys Lys Leu Leu Lys Thr Ser Ser
                245                 250                 255     
Phe His Leu Leu Arg Arg Arg Asp Pro Pro Phe Gln Thr Pro Lys Lys
            260                 265                 270         
Leu Tyr Ala Gln Glu Tyr Glu Phe Glu Ala Asp Glu Asp Lys Ala Asp
        275                 280                 285             
Val Pro Ala Asp Ile Arg Leu Asn Pro Arg Arg Leu Pro Asp Leu Val
    290                 295                 300                 
Ser Ser Cys Arg Ser Arg Pro Ala Leu Ser Pro Leu Gly Asp Ile Asp
305                 310                 315                 320 
Phe Cys Pro Pro Asn Pro Gly Pro Asp Gly Pro Arg Arg Arg Gly Arg
                325                 330                 335     
Lys Pro Thr Lys Ala Lys Arg Asp Gly Pro Pro Arg Pro Arg Gly Arg
            340                 345                 350         
Pro Arg Ile Arg Pro Leu Glu Val Pro Thr Thr Ala Gly Pro Ala Ser
        355                 360                 365             
Ala Ser Thr Pro Thr Asp Gly Ala Lys Lys Pro Arg Gly Arg Gly Arg
    370                 375                 380                 
Gly Arg Gly Arg Lys Ala Glu Glu Ala Gly Gly Thr Arg Leu Glu Pro
385                 390                 395                 400 
Leu Lys Pro Leu Lys Ile Lys Leu Ser Val Pro Lys Ala Gly Glu Gly
                405                 410                 415     
Leu Gly Thr Ser Ser Gly Asp Ala Ile Ser Gly Thr Asp His Asn Ser
            420                 425                 430         
Leu Asp Ser Ser Leu Thr Arg Glu Lys Ile Glu Ala Lys Ile Lys Glu
        435                 440                 445             
Val Glu Glu Lys Gln Pro Glu Met Lys Ser Gly Phe Met Ala Ser Phe
    450                 455                 460                 
Leu Asp Phe Leu Lys Ser Gly Lys Arg His Pro Pro Leu Tyr Gln Ala
465                 470                 475                 480 
Gly Leu Thr Pro Pro Leu Ser Pro Pro Lys Ser Val Pro Pro Ser Val
                485                 490                 495     
Pro Ala Arg Gly Leu Gln Pro Gln Pro Pro Ala Thr Pro Ala Val Pro
            500                 505                 510         
His Pro Pro Pro Ser Gly Ala Phe Gly Leu Gly Gly Ala Leu Glu Ala
        515                 520                 525             
Ala Glu Ser Glu Gly Leu Gly Leu Gly Cys Pro Ser Pro Cys Lys Arg
    530                 535                 540                 
Leu Asp Glu Glu Leu Lys Arg Asn Leu Glu Thr Leu Pro Ser Phe Ser
545                 550                 555                 560 
Ser Asp Glu Glu Asp Ser Val Ala Lys Asn Arg Asp Leu Gln Glu Ser
                565                 570                 575     
Ile Ser Ser Ala Ile Ser Ala Leu Asp Asp Pro Pro Leu Ala Gly Pro
            580                 585                 590         
Lys Asp Thr Ser Thr Pro Asp Gly Pro Pro Leu Ala Pro Ala Ala Ala
        595                 600                 605             
Val Pro Gly Pro Pro Pro Leu Pro Gly Leu Pro Ser Ala Asn Ser Asn
    610                 615                 620                 
Gly Thr Pro Glu Pro Pro Leu Leu Glu Glu Lys Pro Pro Pro Thr Pro
625                 630                 635                 640 
Pro Pro Ala Pro Thr Pro Gln Pro Gln Pro Pro Pro Pro Pro Pro Pro
                645                 650                 655     
Pro Gln Pro Ala Leu Pro Ser Pro Pro Pro Leu Val Ala Pro Thr Pro
            660                 665                 670         
Ser Ser Pro Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro Pro Ala Met
        675                 680                 685             
Pro Ser Pro Pro Pro Pro Pro Pro Pro Ala Ala Ala Pro Leu Ala Ala
    690                 695                 700                 
Pro Pro Glu Glu Pro Ala Ala Pro Ser Pro Glu Asp Pro Glu Leu Pro
705                 710                 715                 720 
Asp Thr Arg Pro Leu His Leu Ala Lys Lys Gln Glu Thr Ala Ala Val
                725                 730                 735     
Cys Gly Glu Thr Asp Glu Glu Ala Gly Glu Ser Gly Gly Glu Gly Ile
            740                 745                 750         
Phe Arg Glu Arg Asp Glu Phe Val Ile Arg Ala Glu Asp Ile Pro Ser
        755                 760                 765             
Leu Lys Trp Arg Cys Arg Arg Gly Val Asn Pro His Pro Ser Gly Glu
    770                 775                 780                 
Ser Arg Arg Pro Phe Cys Arg Asn Ser Leu Arg Arg Ser Arg Thr Ala
785                 790                 795                 800 
Arg Gly Ser Phe Val Pro Pro Val Ile Ile Trp Gly Ile Leu Gly Met
                805                 810                 815     
Gln Lys Ile Gly Thr Ser Ala Ser Met
            820                 825 


<210> 2286
<211> 3389
<212> PRT
<213> Homo sapiens

<400> 2286
Met Thr Ala Trp Arg Arg Phe Gln Ser Leu Leu Leu Leu Leu Gly Leu
 1               5                  10                  15      
Leu Val Leu Cys Ala Arg Leu Leu Thr Ala Ala Lys Gly Gln Asn Cys
            20                  25                  30          
Gly Gly Leu Val Gln Gly Pro Asn Gly Thr Ile Glu Ser Pro Gly Phe
        35                  40                  45              
Pro His Gly Tyr Pro Asn Tyr Ala Asn Cys Thr Trp Ile Ile Ile Thr
    50                  55                  60                  
Gly Glu Arg Asn Arg Ile Gln Leu Ser Phe His Thr Phe Ala Leu Glu
65                  70                  75                  80  
Glu Asn Phe Asp Ile Leu Ser Val Tyr Asp Gly Gln Pro Gln Gln Gly
                85                  90                  95      
Asn Leu Lys Val Arg Leu Ser Gly Phe Gln Leu Pro Ser Ser Ile Val
            100                 105                 110         
Ser Thr Gly Ser Ile Leu Thr Leu Trp Phe Thr Thr Asp Phe Ala Val
        115                 120                 125             
Ser Ala Gln Gly Phe Lys Ala Leu Tyr Glu Val Leu Pro Ser His Thr
    130                 135                 140                 
Cys Gly Asn Pro Gly Glu Ile Leu Lys Gly Val Leu His Gly Thr Arg
145                 150                 155                 160 
Phe Asn Ile Gly Asp Lys Ile Arg Tyr Ser Cys Leu Pro Gly Tyr Ile
                165                 170                 175     
Leu Glu Gly His Ala Ile Leu Thr Cys Ile Val Ser Pro Gly Asn Gly
            180                 185                 190         
Ala Ser Trp Asp Phe Pro Ala Pro Phe Cys Arg Ala Glu Gly Ala Cys
        195                 200                 205             
Gly Gly Thr Leu Arg Gly Thr Ser Ser Ser Ile Ser Ser Pro His Phe
    210                 215                 220                 
Pro Ser Glu Tyr Glu Asn Asn Ala Asp Cys Thr Trp Thr Ile Leu Ala
225                 230                 235                 240 
Glu Pro Gly Asp Thr Ile Ala Leu Val Phe Thr Asp Phe Gln Leu Glu
                245                 250                 255     
Glu Gly Tyr Asp Phe Leu Glu Ile Ser Gly Thr Glu Ala Pro Ser Ile
            260                 265                 270         
Trp Leu Thr Gly Met Asn Leu Pro Ser Pro Val Ile Ser Ser Lys Asn
        275                 280                 285             
Trp Leu Arg Leu His Phe Thr Ser Asp Ser Asn His Arg Arg Lys Gly
    290                 295                 300                 
Phe Asn Ala Gln Phe Gln Val Lys Lys Ala Ile Glu Leu Lys Ser Arg
305                 310                 315                 320 
Gly Val Lys Met Leu Pro Ser Lys Asp Gly Ser His Lys Asn Ser Val
                325                 330                 335     
Leu Ser Gln Gly Gly Val Ala Leu Val Ser His Met Cys Leu Asp Pro
            340                 345                 350         
Gly Ile Pro Glu Asn Gly Arg Arg Ala Gly Ser Asp Phe Ser Arg Val
        355                 360                 365             
Gly Ala Asn Val Gln Phe Ser Cys Glu Asp Asn Tyr Val Leu Gln Gly
    370                 375                 380                 
Ser Lys Ser Ile Thr Cys Gln Arg Val Thr Glu Thr Leu Ala Ala Trp
385                 390                 395                 400 
Ser Asp His Arg Pro Ile Cys Arg Ala Arg Thr Cys Gly Ser Asn Leu
                405                 410                 415     
Arg Gly Pro Ser Gly Val Ile Thr Ser Pro Asn Tyr Pro Val Gln Tyr
            420                 425                 430         
Glu Asp Asn Ala His Cys Val Trp Val Ile Thr Thr Thr Asp Pro Asp
        435                 440                 445             
Lys Val Ile Lys Leu Ala Phe Glu Glu Phe Glu Leu Glu Arg Gly Tyr
    450                 455                 460                 
Asp Thr Leu Thr Val Gly Asp Ala Gly Lys Val Gly Asp Thr Arg Ser
465                 470                 475                 480 
Val Leu Tyr Val Leu Thr Gly Ser Ser Val Pro Asp Leu Ile Val Ser
                485                 490                 495     
Met Ser Asn Gln Met Trp Leu His Leu Gln Ser Asp Asp Ser Ile Gly
            500                 505                 510         
Ser Pro Gly Phe Lys Ala Val Tyr Gln Glu Ile Glu Lys Gly Gly Cys
        515                 520                 525             
Gly Asp Pro Gly Ile Pro Ala Tyr Gly Lys Arg Thr Gly Ser Ser Phe
    530                 535                 540                 
Leu His Gly Asp Thr Leu Thr Phe Glu Cys Pro Ala Ala Phe Glu Leu
545                 550                 555                 560 
Val Gly Glu Arg Val Ile Thr Cys Gln Gln Asn Asn Gln Trp Ser Gly
                565                 570                 575     
Asn Lys Pro Ser Cys Val Phe Ser Cys Phe Phe Asn Phe Thr Ala Ser
            580                 585                 590         
Ser Gly Ile Ile Leu Ser Pro Asn Tyr Pro Glu Glu Tyr Gly Asn Asn
        595                 600                 605             
Met Asn Cys Val Trp Leu Ile Ile Ser Glu Pro Gly Ser Arg Ile His
    610                 615                 620                 
Leu Ile Phe Asn Asp Phe Asp Val Glu Pro Gln Phe Asp Phe Leu Ala
625                 630                 635                 640 
Val Lys Asp Asn Gly Ile Ser Asp Ile Thr Val Leu Gly Thr Phe Ser
                645                 650                 655     
Gly Asn Glu Val Pro Ser Gln Leu Ala Ser Ser Gly His Ile Val Arg
            660                 665                 670         
Leu Glu Phe Gln Ser Asp His Ser Thr Thr Gly Arg Gly Phe Asn Ile
        675                 680                 685             
Thr Tyr Thr Thr Phe Gly Gln Asn Glu Cys His Asp Pro Gly Ile Pro
    690                 695                 700                 
Ile Asn Gly Arg Arg Phe Gly Asp Arg Phe Leu Leu Gly Ser Ser Val
705                 710                 715                 720 
Ser Phe His Cys Asp Asp Gly Phe Val Lys Thr Gln Gly Ser Glu Ser
                725                 730                 735     
Ile Thr Cys Ile Leu Gln Asp Gly Asn Val Val Trp Ser Ser Thr Val
            740                 745                 750         
Pro Arg Cys Glu Ala Pro Cys Gly Gly His Leu Thr Ala Ser Ser Gly
        755                 760                 765             
Val Ile Leu Pro Pro Gly Trp Pro Gly Tyr Tyr Lys Asp Ser Leu His
    770                 775                 780                 
Cys Glu Trp Ile Ile Glu Ala Lys Pro Gly His Ser Ile Lys Met Thr
785                 790                 795                 800 
Phe Asp Arg Phe Gln Thr Glu Val Asn Tyr Asp Thr Leu Glu Val Arg
                805                 810                 815     
Asp Gly Pro Ala Ser Ser Ser Pro Leu Ile Gly Glu Tyr His Gly Thr
            820                 825                 830         
Gln Ala Pro Gln Phe Leu Ile Ser Thr Gly Asn Phe Met Tyr Leu Leu
        835                 840                 845             
Phe Thr Thr Asp Asn Ser Arg Ser Ser Ile Gly Phe Leu Ile His Tyr
    850                 855                 860                 
Glu Ser Val Thr Leu Glu Ser Asp Ser Cys Leu Asp Pro Gly Ile Pro
865                 870                 875                 880 
Val Asn Gly His Arg His Gly Gly Asp Phe Gly Ile Arg Ser Thr Val
                885                 890                 895     
Thr Phe Ser Cys Asp Pro Gly Tyr Thr Leu Ser Asp Asp Glu Pro Leu
            900                 905                 910         
Val Cys Glu Arg Asn His Gln Trp Asn His Ala Leu Pro Ser Cys Asp
        915                 920                 925             
Ala Leu Cys Gly Gly Tyr Ile Gln Gly Lys Ser Gly Thr Val Leu Ser
    930                 935                 940                 
Pro Gly Phe Pro Asp Phe Tyr Pro Asn Ser Leu Asn Cys Thr Trp Thr
945                 950                 955                 960 
Ile Glu Val Ser His Gly Lys Gly Val Gln Met Ile Phe His Thr Phe
                965                 970                 975     
His Leu Glu Ser Ser His Asp Tyr Leu Leu Ile Thr Glu Asp Gly Ser
            980                 985                 990         
Phe Ser Glu Pro Val Ala Arg Leu Thr Gly Ser Val Leu Pro His Thr
        995                 1000                1005            
Ile Lys Ala Gly Leu Phe Gly Asn Phe Thr Ala Gln Leu Arg Phe Ile
    1010                1015                1020                
Ser Asp Phe Ser Ile Ser Tyr Glu Gly Phe Asn Ile Thr Phe Ser Glu
1025                1030                1035                1040
Tyr Asp Leu Glu Pro Cys Asp Asp Pro Gly Val Pro Ala Phe Ser Arg
                1045                1050                1055    
Arg Ile Gly Phe His Phe Gly Val Gly Asp Ser Leu Thr Phe Ser Cys
            1060                1065                1070        
Phe Leu Gly Tyr Arg Leu Glu Gly Ala Thr Lys Leu Thr Cys Leu Gly
        1075                1080                1085            
Gly Gly Arg Arg Val Trp Ser Ala Pro Leu Pro Arg Cys Val Ala Glu
    1090                1095                1100                
Cys Gly Ala Ser Val Lys Gly Asn Glu Gly Thr Leu Leu Ser Pro Asn
1105                1110                1115                1120
Phe Pro Ser Asn Tyr Asp Asn Thr His Glu Cys Ile Tyr Lys Ile Glu
                1125                1130                1135    
Thr Glu Ala Gly Lys Gly Ile His Leu Arg Thr Arg Ser Phe Gln Leu
            1140                1145                1150        
Phe Glu Gly Asp Thr Leu Lys Val Tyr Asp Gly Lys Asp Ser Ser Ser
        1155                1160                1165            
Arg Pro Leu Gly Thr Phe Thr Lys Asn Glu Leu Leu Gly Leu Ile Leu
    1170                1175                1180                
Asn Ser Thr Ser Asn His Leu Trp Leu Glu Phe Asn Thr Asn Gly Ser
1185                1190                1195                1200
Asp Thr Asp Gln Gly Phe Gln Leu Thr Tyr Thr Ser Phe Asp Leu Val
                1205                1210                1215    
Lys Cys Glu Asp Pro Gly Ile Pro Asn Tyr Gly Tyr Arg Ile Arg Asp
            1220                1225                1230        
Glu Gly His Phe Thr Asp Thr Val Val Leu Tyr Ser Cys Asn Pro Gly
        1235                1240                1245            
Tyr Ala Met His Gly Ser Asn Thr Leu Thr Cys Leu Ser Gly Asp Arg
    1250                1255                1260                
Arg Val Trp Asp Lys Pro Leu Pro Ser Cys Ile Ala Glu Cys Gly Gly
1265                1270                1275                1280
Gln Ile His Ala Ala Thr Ser Gly Arg Ile Leu Ser Pro Gly Tyr Pro
                1285                1290                1295    
Ala Pro Tyr Asp Asn Asn Leu His Cys Thr Trp Ile Ile Glu Ala Asp
            1300                1305                1310        
Pro Gly Lys Thr Ile Ser Leu His Phe Ile Val Phe Asp Thr Glu Met
        1315                1320                1325            
Ala His Asp Ile Leu Lys Val Trp Asp Gly Pro Val Asp Ser Asp Ile
    1330                1335                1340                
Leu Leu Lys Glu Trp Ser Gly Ser Ala Leu Pro Glu Asp Ile His Ser
1345                1350                1355                1360
Thr Phe Asn Ser Leu Thr Leu Gln Phe Asp Ser Asp Phe Phe Ile Ser
                1365                1370                1375    
Lys Ser Gly Phe Ser Ile Gln Phe Ser Thr Ser Ile Ala Ala Thr Cys
            1380                1385                1390        
Asn Asp Pro Gly Met Pro Gln Asn Gly Thr Arg Tyr Gly Asp Ser Arg
        1395                1400                1405            
Glu Ala Gly Asp Thr Val Thr Phe Gln Cys Asp Pro Gly Tyr Gln Leu
    1410                1415                1420                
Gln Gly Gln Ala Lys Ile Thr Cys Val Gln Leu Asn Asn Arg Phe Phe
1425                1430                1435                1440
Trp Gln Pro Asp Pro Pro Thr Cys Ile Ala Ala Cys Gly Gly Asn Leu
                1445                1450                1455    
Thr Gly Pro Ala Gly Val Ile Leu Ser Pro Asn Tyr Pro Gln Pro Tyr
            1460                1465                1470        
Pro Pro Gly Lys Glu Cys Asp Trp Arg Val Lys Val Asn Pro Asp Phe
        1475                1480                1485            
Val Ile Ala Leu Ile Phe Lys Ser Phe Asn Met Glu Pro Ser Tyr Asp
    1490                1495                1500                
Phe Leu His Ile Tyr Glu Gly Glu Asp Ser Asn Ser Pro Leu Ile Gly
1505                1510                1515                1520
Ser Tyr Gln Gly Ser Gln Ala Pro Glu Arg Ile Glu Ser Ser Gly Asn
                1525                1530                1535    
Ser Leu Phe Leu Ala Phe Arg Ser Asp Ala Ser Val Gly Leu Ser Gly
            1540                1545                1550        
Phe Ala Ile Glu Phe Lys Glu Lys Pro Arg Glu Ala Cys Phe Asp Pro
        1555                1560                1565            
Gly Asn Ile Met Asn Gly Thr Arg Val Gly Thr Asp Phe Lys Leu Gly
    1570                1575                1580                
Ser Thr Ile Thr Tyr Gln Cys Asp Ser Gly Tyr Lys Ile Leu Asp Pro
1585                1590                1595                1600
Ser Ser Ile Thr Cys Val Ile Gly Ala Asp Gly Lys Pro Ser Trp Asp
                1605                1610                1615    
Gln Val Leu Pro Ser Cys Asn Ala Pro Cys Gly Gly Gln Tyr Thr Gly
            1620                1625                1630        
Ser Glu Gly Val Val Leu Ser Pro Asn Tyr Pro His Asn Tyr Thr Ala
        1635                1640                1645            
Gly Gln Ile Cys Leu Tyr Ser Ile Thr Val Pro Lys Glu Phe Val Val
    1650                1655                1660                
Phe Gly Gln Phe Ala Tyr Phe Gln Thr Ala Leu Asn Asp Leu Ala Glu
1665                1670                1675                1680
Leu Phe Asp Gly Thr His Ala Gln Ala Arg Leu Leu Ser Ser Leu Ser
                1685                1690                1695    
Gly Ser His Ser Gly Glu Thr Leu Pro Leu Ala Thr Ser Asn Gln Ile
            1700                1705                1710        
Leu Leu Arg Phe Ser Ala Lys Ser Gly Ala Ser Ala Arg Gly Phe His
        1715                1720                1725            
Phe Val Tyr Gln Ala Val Pro Arg Thr Ser Asp Thr Gln Cys Ser Ser
    1730                1735                1740                
Val Pro Glu Pro Arg Tyr Gly Arg Arg Ile Gly Ser Glu Phe Ser Ala
1745                1750                1755                1760
Gly Ser Ile Val Arg Phe Glu Cys Asn Pro Gly Tyr Leu Leu Gln Gly
                1765                1770                1775    
Ser Thr Ala Leu His Cys Gln Ser Val Pro Asn Ala Leu Ala Gln Trp
            1780                1785                1790        
Asn Asp Thr Ile Pro Ser Cys Val Val Pro Cys Ser Gly Asn Phe Thr
        1795                1800                1805            
Gln Arg Arg Gly Thr Ile Leu Ser Pro Gly Tyr Pro Glu Pro Tyr Gly
    1810                1815                1820                
Asn Asn Leu Asn Cys Ile Trp Lys Ile Ile Val Thr Glu Gly Ser Gly
1825                1830                1835                1840
Ile Gln Asp Pro Ser Asp Gln Phe Cys His Gly Ala Glu Leu Gly Leu
                1845                1850                1855    
Pro Phe Glu Ile His Asp Gly Gly Asp Val Thr Ala Pro Arg Leu Gly
            1860                1865                1870        
Ser Phe Ser Gly Thr Thr Val Pro Ala Leu Leu Asn Ser Thr Ser Asn
        1875                1880                1885            
Gln Leu Tyr Leu His Phe Gln Ser Asp Ile Ser Val Ala Ala Ala Gly
    1890                1895                1900                
Phe His Leu Glu Tyr Lys Thr Val Gly Leu Ala Ala Cys Gln Glu Pro
1905                1910                1915                1920
Ala Leu Pro Ser Asn Ser Ile Lys Ile Gly Asp Arg Tyr Met Val Asn
                1925                1930                1935    
Asp Val Leu Ser Phe Gln Cys Glu Pro Gly Tyr Thr Leu Gln Gly Arg
            1940                1945                1950        
Ser His Ile Ser Cys Met Pro Gly Thr Val Arg Arg Trp Asn Tyr Pro
        1955                1960                1965            
Ser Pro Leu Cys Ile Ala Thr Cys Gly Gly Thr Leu Ser Thr Leu Gly
    1970                1975                1980                
Gly Val Ile Leu Ser Pro Gly Phe Pro Gly Ser Tyr Pro Asn Asn Leu
1985                1990                1995                2000
Asp Cys Thr Trp Arg Ile Ser Leu Pro Ile Gly Tyr Gly Ala His Ile
                2005                2010                2015    
Gln Phe Leu Asn Phe Ser Thr Glu Ala Asn His Asp Phe Leu Glu Ile
            2020                2025                2030        
Gln Asn Gly Pro Tyr His Thr Ser Pro Met Ile Gly Gln Phe Ser Gly
        2035                2040                2045            
Thr Asp Leu Pro Ala Ala Leu Leu Ser Thr Thr His Glu Thr Leu Ile
    2050                2055                2060                
His Phe Tyr Ser Asp His Ser Gln Asn Arg Gln Gly Phe Lys Leu Ala
2065                2070                2075                2080
Tyr Gln Ala Tyr Glu Leu Gln Asn Cys Pro Asp Pro Pro Pro Phe Gln
                2085                2090                2095    
Asn Gly Tyr Met Ile Asn Ser Asp Tyr Ser Val Gly Gln Ser Val Ser
            2100                2105                2110        
Phe Glu Cys Tyr Pro Gly Tyr Ile Leu Ile Gly His Pro Val Leu Thr
        2115                2120                2125            
Cys Gln His Gly Ile Asn Arg Asn Trp Asn Tyr Pro Phe Pro Arg Cys
    2130                2135                2140                
Asp Ala Pro Cys Gly Tyr Asn Val Thr Ser Gln Asn Gly Thr Ile Tyr
2145                2150                2155                2160
Ser Pro Gly Phe Pro Asp Glu Tyr Pro Ile Leu Lys Asp Cys Ile Trp
                2165                2170                2175    
Leu Ile Thr Val Pro Pro Gly His Gly Val Tyr Ile Asn Phe Thr Leu
            2180                2185                2190        
Leu Gln Thr Glu Ala Val Asn Asp Tyr Ile Ala Val Trp Asp Gly Pro
        2195                2200                2205            
Asp Gln Asn Ser Pro Gln Leu Gly Val Phe Ser Gly Asn Thr Ala Leu
    2210                2215                2220                
Glu Thr Ala Tyr Ser Ser Thr Asn Gln Val Leu Leu Lys Phe His Ser
2225                2230                2235                2240
Asp Phe Ser Asn Gly Gly Phe Phe Val Leu Asn Phe His Ala Phe Gln
                2245                2250                2255    
Leu Lys Lys Cys Gln Pro Pro Pro Ala Val Pro Gln Ala Glu Met Leu
            2260                2265                2270        
Thr Glu Asp Asp Asp Phe Glu Ile Gly Asp Phe Val Lys Tyr Gln Cys
        2275                2280                2285            
His Pro Gly Tyr Thr Leu Val Gly Thr Asp Ile Leu Thr Cys Lys Leu
    2290                2295                2300                
Ser Ser Gln Leu Gln Phe Glu Gly Ser Leu Pro Thr Cys Glu Ala Gln
2305                2310                2315                2320
Cys Pro Ala Asn Glu Val Arg Thr Gly Ser Ser Gly Val Ile Leu Ser
                2325                2330                2335    
Pro Gly Tyr Pro Gly Asn Tyr Phe Asn Ser Gln Thr Cys Ser Trp Ser
            2340                2345                2350        
Ile Lys Val Glu Pro Asn Tyr Asn Ile Thr Ile Phe Val Asp Thr Phe
        2355                2360                2365            
Gln Ser Glu Lys Gln Phe Asp Ala Leu Glu Val Phe Asp Gly Ser Ser
    2370                2375                2380                
Gly Gln Ser Pro Leu Leu Val Val Leu Ser Gly Asn His Thr Glu Gln
2385                2390                2395                2400
Ser Asn Phe Thr Ser Arg Ser Asn Gln Leu Tyr Leu Arg Trp Ser Thr
                2405                2410                2415    
Asp His Ala Thr Ser Lys Lys Gly Phe Lys Ile Arg Tyr Ala Ala Pro
            2420                2425                2430        
Tyr Cys Ser Leu Thr His Pro Leu Lys Asn Gly Gly Ile Leu Asn Arg
        2435                2440                2445            
Thr Ala Gly Ala Val Gly Ser Lys Val His Tyr Phe Cys Lys Pro Gly
    2450                2455                2460                
Tyr Arg Met Val Gly His Ser Asn Ala Thr Cys Arg Arg Asn Pro Leu
2465                2470                2475                2480
Gly Met Tyr Gln Trp Asp Ser Leu Thr Pro Leu Cys Gln Ala Val Ser
                2485                2490                2495    
Cys Gly Ile Pro Glu Ser Pro Gly Asn Gly Ser Phe Thr Gly Asn Glu
            2500                2505                2510        
Phe Thr Leu Asp Ser Lys Val Val Tyr Glu Cys His Glu Gly Phe Lys
        2515                2520                2525            
Leu Glu Ser Ser Gln Gln Ala Thr Ala Val Cys Gln Glu Asp Gly Leu
    2530                2535                2540                
Trp Ser Asn Lys Gly Lys Pro Pro Met Cys Lys Pro Val Ala Cys Pro
2545                2550                2555                2560
Ser Ile Glu Ala Gln Leu Ser Glu His Val Ile Trp Arg Leu Val Ser
                2565                2570                2575    
Gly Ser Leu Asn Glu Tyr Gly Ala Gln Val Leu Leu Ser Cys Ser Pro
            2580                2585                2590        
Gly Tyr Tyr Leu Glu Gly Trp Arg Leu Leu Arg Cys Gln Ala Asn Gly
        2595                2600                2605            
Thr Trp Asn Ile Gly Asp Glu Arg Pro Ser Cys Arg Ala Gly His Cys
    2610                2615                2620                
Gly Ser Pro Asp Pro Ile Val Asn Gly His Ile Ser Gly Asp Gly Phe
2625                2630                2635                2640
Ser Tyr Arg Asp Thr Val Val Tyr Gln Cys Asn Pro Gly Phe Arg Leu
                2645                2650                2655    
Val Gly Thr Ser Val Arg Ile Cys Leu Gln Asp His Lys Trp Ser Gly
            2660                2665                2670        
Gln Thr Pro Val Cys Val Pro Ile Thr Cys Gly His Pro Gly Asn Pro
        2675                2680                2685            
Ala His Gly Phe Thr Asn Gly Ser Glu Phe Asn Leu Asn Asp Val Val
    2690                2695                2700                
Asn Phe Thr Cys Asn Thr Gly Tyr Leu Leu Gln Gly Val Ser Arg Ala
2705                2710                2715                2720
Gln Cys Arg Ser Asn Gly Gln Trp Ser Ser Pro Leu Pro Thr Cys Arg
                2725                2730                2735    
Val Val Asn Cys Ser Asp Pro Gly Phe Val Glu Asn Ala Ile Arg His
            2740                2745                2750        
Gly Gln Gln Asn Phe Pro Glu Ser Phe Glu Tyr Gly Met Ser Ile Leu
        2755                2760                2765            
Tyr His Cys Lys Lys Gly Phe His Leu Leu Gly Ser Ser Ala Leu Thr
    2770                2775                2780                
Cys Met Ala Asn Gly Leu Trp Asp Arg Ser Leu Pro Lys Cys Leu Ala
2785                2790                2795                2800
Ile Ser Cys Gly His Pro Gly Val Pro Ala Asn Ala Val Leu Thr Gly
                2805                2810                2815    
Glu Leu Phe Thr Tyr Gly Ala Val Val His Tyr Ser Cys Arg Gly Ser
            2820                2825                2830        
Glu Ser Leu Ile Gly Asn Asp Thr Arg Val Cys Gln Glu Asp Ser His
        2835                2840                2845            
Trp Ser Gly Ala Leu Pro His Cys Thr Gly Asn Asn Pro Gly Phe Cys
    2850                2855                2860                
Gly Asp Pro Gly Thr Pro Ala His Gly Ser Arg Leu Gly Asp Asp Phe
2865                2870                2875                2880
Lys Thr Lys Ser Leu Leu Arg Phe Ser Cys Glu Met Gly His Gln Leu
                2885                2890                2895    
Arg Gly Ser Pro Glu Arg Thr Cys Leu Leu Asn Gly Ser Trp Ser Gly
            2900                2905                2910        
Leu Gln Pro Val Cys Glu Ala Val Leu Cys Pro Gln Pro Pro Pro Val
        2915                2920                2925            
Gln Asn Gly Thr Val Glu Gly Ser Asp Phe Arg Trp Gly Ser Ser Ile
    2930                2935                2940                
Ser Tyr Ser Cys Met Asp Gly Tyr Gln Leu Ser His Ser Ala Ile Leu
2945                2950                2955                2960
Ser Cys Glu Gly Arg Gly Val Trp Lys Gly Glu Ile Pro Gln Cys Leu
                2965                2970                2975    
Pro Val Phe Cys Gly Asp Pro Gly Ile Pro Ala Glu Gly Arg Leu Ser
            2980                2985                2990        
Gly Lys Ser Phe Thr Tyr Lys Ser Glu Val Phe Phe Gln Cys Lys Ser
        2995                3000                3005            
Pro Phe Ile Leu Val Gly Ser Ser Arg Arg Val Cys Gln Ala Asp Gly
    3010                3015                3020                
Thr Trp Ser Gly Ile Gln Pro Thr Cys Ile Asp Pro Ala His Asn Thr
3025                3030                3035                3040
Cys Pro Asp Pro Gly Thr Pro His Phe Gly Ile Gln Asn Ser Ser Arg
                3045                3050                3055    
Gly Tyr Glu Val Gly Ser Thr Val Phe Phe Arg Cys Arg Lys Gly Tyr
            3060                3065                3070        
His Ile Gln Gly Ser Thr Thr Arg Thr Cys Leu Ala Asn Leu Thr Trp
        3075                3080                3085            
Ser Gly Ile Gln Thr Glu Cys Ile Pro His Ala Cys Arg Gln Pro Glu
    3090                3095                3100                
Thr Pro Ala His Ala Asp Val Arg Ala Ile Asp Leu Pro Thr Phe Gly
3105                3110                3115                3120
Tyr Thr Leu Val Tyr Thr Cys His Pro Gly Phe Phe Leu Ala Gly Gly
                3125                3130                3135    
Ser Glu His Arg Thr Cys Lys Ala Asp Met Lys Trp Thr Gly Lys Ser
            3140                3145                3150        
Pro Val Cys Lys Ser Lys Gly Val Arg Glu Val Asn Glu Thr Val Thr
        3155                3160                3165            
Lys Thr Pro Val Pro Ser Asp Val Phe Phe Val Asn Ser Leu Trp Lys
    3170                3175                3180                
Gly Tyr Tyr Glu Tyr Leu Gly Lys Arg Gln Pro Ala Thr Leu Thr Val
3185                3190                3195                3200
Asp Trp Phe Asn Ala Thr Ser Ser Lys Val Asn Ala Thr Phe Ser Glu
                3205                3210                3215    
Ala Ser Pro Val Glu Leu Lys Leu Thr Gly Ile Tyr Lys Lys Glu Glu
            3220                3225                3230        
Ala His Leu Leu Leu Lys Ala Phe Gln Ile Lys Gly Gln Ala Asp Ile
        3235                3240                3245            
Phe Val Ser Lys Phe Glu Asn Asp Asn Trp Gly Leu Asp Gly Tyr Val
    3250                3255                3260                
Ser Ser Gly Leu Glu Arg Gly Gly Phe Thr Phe Gln Gly Asp Ile His
3265                3270                3275                3280
Gly Lys Asp Phe Gly Lys Phe Lys Leu Glu Arg Gln Asp Pro Leu Asn
                3285                3290                3295    
Pro Asp Gln Asp Ser Ser Ser His Tyr His Gly Thr Ser Ser Gly Ser
            3300                3305                3310        
Val Ala Ala Ala Ile Leu Val Pro Phe Phe Ala Leu Ile Leu Ser Gly
        3315                3320                3325            
Phe Ala Phe Tyr Leu Tyr Lys His Arg Thr Arg Pro Lys Val Gln Tyr
    3330                3335                3340                
Asn Gly Tyr Ala Gly His Glu Asn Ser Asn Gly Gln Ala Ser Phe Glu
3345                3350                3355                3360
Asn Pro Met Tyr Asp Thr Asn Leu Lys Pro Thr Glu Ala Lys Ala Val
                3365                3370                3375    
Arg Phe Asp Thr Thr Leu Asn Thr Val Cys Thr Val Val
            3380                3385                


<210> 2287
<211> 3664
<212> PRT
<213> Homo sapiens

<400> 2287
Met Val Arg Glu Thr Arg His Leu Trp Val Gly Asn Leu Pro Glu Asn
 1               5                  10                  15      
Val Arg Glu Glu Lys Ile Ile Glu His Phe Lys Arg Tyr Gly Arg Val
            20                  25                  30          
Glu Ser Val Lys Ile Leu Pro Lys Arg Gly Ser Glu Gly Gly Val Ala
        35                  40                  45              
Ala Phe Val Asp Phe Val Asp Ile Lys Ser Ala Gln Lys Ala His Asn
    50                  55                  60                  
Ser Val Asn Lys Met Gly Asp Arg Asp Leu Arg Thr Asp Tyr Asn Glu
65                  70                  75                  80  
Pro Gly Thr Ile Pro Ser Ala Ala Arg Gly Leu Asp Asp Thr Val Ser
                85                  90                  95      
Ile Ala Ser Arg Ser Arg Glu Val Ser Gly Phe Arg Gly Gly Gly Gly
            100                 105                 110         
Gly Pro Ala Tyr Gly Pro Pro Pro Ser Leu His Ala Arg Glu Gly Arg
        115                 120                 125             
Tyr Glu Arg Arg Leu Asp Gly Ala Ser Asp Asn Arg Glu Arg Ala Tyr
    130                 135                 140                 
Glu His Ser Ala Tyr Gly His His Glu Arg Gly Thr Gly Gly Phe Asp
145                 150                 155                 160 
Arg Thr Arg His Tyr Asp Gln Asp Tyr Tyr Arg Asp Pro Arg Glu Arg
                165                 170                 175     
Thr Leu Gln His Gly Leu Tyr Tyr Ala Ser Arg Ser Arg Ser Pro Asn
            180                 185                 190         
Arg Phe Asp Ala His Asp Pro Arg Tyr Glu Pro Arg Ala Arg Glu Gln
        195                 200                 205             
Phe Thr Leu Pro Ser Val Val His Arg Asp Ile Tyr Arg Asp Asp Ile
    210                 215                 220                 
Thr Arg Glu Val Arg Gly Arg Arg Pro Glu Arg Asn Tyr Gln His Ser
225                 230                 235                 240 
Arg Ser Arg Ser Pro His Ser Ser Gln Ser Arg Asn Gln Ser Pro Gln
                245                 250                 255     
Arg Leu Ala Ser Gln Ala Ser Arg Pro Thr Arg Ser Pro Ser Gly Ser
            260                 265                 270         
Gly Ser Arg Ser Arg Ser Ser Ser Ser Asp Ser Ile Ser Ser Ser Ser
        275                 280                 285             
Ser Thr Ser Ser Asp Ser Ser Asp Ser Ser Ser Ser Ser Ser Asp Asp
    290                 295                 300                 
Ser Pro Ala Arg Ser Val Gln Ser Ala Ala Val Pro Ala Pro Thr Ser
305                 310                 315                 320 
Gln Leu Leu Ser Ser Leu Glu Lys Asp Glu Pro Arg Lys Ser Phe Gly
                325                 330                 335     
Ile Lys Val Gln Asn Leu Pro Val Arg Ser Thr Asp Thr Ser Leu Lys
            340                 345                 350         
Asp Gly Leu Phe His Glu Phe Lys Lys Phe Gly Lys Val Thr Ser Val
        355                 360                 365             
Gln Ile His Gly Thr Ser Glu Glu Arg Tyr Gly Leu Val Phe Phe Arg
    370                 375                 380                 
Gln Gln Glu Asp Gln Glu Lys Ala Leu Thr Ala Ser Lys Gly Lys Leu
385                 390                 395                 400 
Phe Phe Gly Met Gln Ile Glu Val Thr Ala Trp Ile Gly Pro Glu Thr
                405                 410                 415     
Glu Ser Glu Asn Glu Phe Arg Pro Leu Asp Glu Arg Ile Asp Glu Phe
            420                 425                 430         
His Pro Lys Ala Thr Arg Thr Leu Phe Ile Gly Asn Leu Glu Lys Thr
        435                 440                 445             
Thr Thr Tyr His Asp Leu Arg Asn Ile Phe Gln Arg Phe Gly Glu Ile
    450                 455                 460                 
Val Asp Ile Asp Ile Lys Lys Val Asn Gly Val Pro Gln Tyr Ala Phe
465                 470                 475                 480 
Leu Gln Tyr Cys Asp Ile Ala Ser Val Cys Lys Ala Ile Lys Lys Met
                485                 490                 495     
Asp Gly Glu Tyr Leu Gly Asn Asn Arg Leu Lys Leu Gly Phe Gly Lys
            500                 505                 510         
Ser Met Pro Thr Asn Cys Val Trp Leu Asp Gly Leu Ser Ser Asn Val
        515                 520                 525             
Ser Asp Gln Tyr Leu Thr Arg His Phe Cys Arg Tyr Gly Pro Val Val
    530                 535                 540                 
Lys Val Val Phe Asp Arg Leu Lys Gly Met Ala Leu Val Leu Tyr Asn
545                 550                 555                 560 
Glu Ile Glu Tyr Ala Gln Ala Ala Val Lys Glu Thr Lys Gly Arg Lys
                565                 570                 575     
Ile Gly Gly Asn Lys Ile Lys Val Asp Phe Ala Asn Arg Glu Ser Gln
            580                 585                 590         
Leu Ala Phe Tyr His Cys Met Glu Lys Ser Gly Gln Asp Ile Arg Asp
        595                 600                 605             
Phe Tyr Glu Met Leu Ala Glu Arg Arg Glu Glu Arg Arg Ala Ser Tyr
    610                 615                 620                 
Asp Tyr Asn Gln Asp Arg Thr Tyr Tyr Glu Ser Val Arg Thr Pro Gly
625                 630                 635                 640 
Thr Tyr Pro Glu Asp Ser Arg Arg Asp Tyr Pro Ala Arg Gly Arg Glu
                645                 650                 655     
Phe Tyr Ser Glu Trp Glu Thr Tyr Gln Gly Asp Tyr Tyr Glu Ser Arg
            660                 665                 670         
Tyr Tyr Asp Asp Pro Arg Glu Tyr Arg Asp Tyr Arg Asn Asp Pro Tyr
        675                 680                 685             
Glu Gln Asp Ile Arg Glu Tyr Ser Tyr Arg Gln Arg Glu Arg Glu Arg
    690                 695                 700                 
Glu Arg Glu Arg Phe Glu Ser Asp Arg Asp Arg Asp His Glu Arg Arg
705                 710                 715                 720 
Pro Ile Glu Arg Ser Gln Ser Pro Val His Leu Arg Arg Pro Gln Ser
                725                 730                 735     
Pro Gly Ala Ser Pro Ser Gln Ala Glu Arg Leu Pro Ser Asp Ser Glu
            740                 745                 750         
Arg Arg Leu Tyr Ser Arg Ser Ser Asp Arg Ser Gly Ser Cys Ser Ser
        755                 760                 765             
Leu Ser Pro Pro Arg Tyr Glu Lys Leu Asp Lys Ser Arg Leu Glu Arg
    770                 775                 780                 
Tyr Thr Lys Asn Glu Lys Thr Asp Lys Glu Arg Thr Phe Asp Pro Glu
785                 790                 795                 800 
Arg Val Glu Arg Glu Arg Arg Leu Ile Arg Lys Glu Lys Val Glu Lys
                805                 810                 815     
Asp Lys Thr Asp Lys Gln Lys Arg Lys Gly Lys Val His Ser Pro Ser
            820                 825                 830         
Ser Gln Ser Ser Glu Thr Asp Gln Glu Asn Glu Arg Glu Gln Ser Pro
        835                 840                 845             
Glu Lys Pro Arg Ser Cys Asn Lys Leu Ser Arg Glu Lys Ala Asp Lys
    850                 855                 860                 
Glu Gly Ile Ala Lys Asn Arg Leu Glu Leu Met Pro Cys Val Val Leu
865                 870                 875                 880 
Thr Arg Val Lys Glu Lys Glu Gly Lys Val Ile Asp His Thr Pro Val
                885                 890                 895     
Glu Lys Leu Lys Ala Lys Leu Asp Asn Asp Thr Val Lys Ser Ser Ala
            900                 905                 910         
Leu Asp Gln Lys Leu Gln Val Ser Gln Thr Glu Pro Ala Lys Ser Asp
        915                 920                 925             
Leu Ser Lys Leu Glu Ser Val Arg Met Lys Val Pro Lys Glu Lys Gly
    930                 935                 940                 
Leu Ser Ser His Val Glu Val Val Glu Lys Glu Gly Arg Leu Lys Ala
945                 950                 955                 960 
Arg Lys His Leu Lys Pro Glu Gln Pro Ala Asp Gly Val Ser Ala Val
                965                 970                 975     
Asp Leu Glu Lys Leu Glu Ala Arg Lys Arg Arg Phe Ala Asp Ser Asn
            980                 985                 990         
Leu Lys Ala Glu Lys Gln Lys Pro Glu Val Lys Lys Ser Ser Pro Glu
        995                 1000                1005            
Met Glu Asp Ala Arg Val Leu Ser Lys Lys Gln Pro Asp Val Ser Ser
    1010                1015                1020                
Arg Glu Val Ile Leu Leu Arg Glu Gly Glu Ala Glu Arg Lys Pro Val
1025                1030                1035                1040
Arg Lys Glu Ile Leu Lys Arg Glu Ser Lys Lys Ile Lys Leu Asp Arg
                1045                1050                1055    
Leu Asn Thr Val Ala Ser Pro Lys Asp Cys Gln Glu Leu Ala Ser Ile
            1060                1065                1070        
Ser Val Gly Ser Gly Ser Arg Pro Ser Ser Asp Leu Gln Ala Arg Leu
        1075                1080                1085            
Gly Glu Leu Ala Gly Glu Ser Val Glu Asn Gln Glu Val Gln Ser Lys
    1090                1095                1100                
Lys Pro Ile Pro Ser Lys Pro Gln Leu Lys Gln Leu Gln Val Leu Asp
1105                1110                1115                1120
Asp Gln Gly Pro Glu Arg Glu Asp Val Arg Lys Asn Tyr Cys Ser Leu
                1125                1130                1135    
Arg Asp Glu Thr Pro Glu Arg Lys Ser Gly Gln Glu Lys Ser His Ser
            1140                1145                1150        
Val Asn Thr Glu Glu Lys Ile Gly Ile Asp Ile Asp His Thr Gln Ser
        1155                1160                1165            
Tyr Arg Lys Gln Met Glu Gln Ser Arg Arg Lys Gln Gln Met Glu Met
    1170                1175                1180                
Glu Ile Ala Lys Ser Glu Lys Phe Gly Ser Pro Lys Lys Asp Val Asp
1185                1190                1195                1200
Glu Tyr Glu Arg Arg Ser Leu Val His Glu Val Gly Lys Pro Pro Gln
                1205                1210                1215    
Asp Val Thr Asp Asp Ser Pro Pro Ser Lys Lys Lys Arg Met Asp His
            1220                1225                1230        
Val Asp Phe Asp Ile Cys Thr Lys Arg Glu Arg Asn Tyr Arg Ser Ser
        1235                1240                1245            
Arg Gln Ile Ser Glu Asp Ser Glu Arg Thr Gly Gly Ser Pro Ser Val
    1250                1255                1260                
Arg His Gly Ser Phe His Glu Asp Glu Asp Pro Ile Gly Ser Pro Arg
1265                1270                1275                1280
Leu Leu Ser Val Lys Gly Ser Pro Lys Val Asp Glu Lys Val Leu Pro
                1285                1290                1295    
Tyr Ser Asn Ile Thr Val Arg Glu Glu Ser Leu Lys Phe Asn Pro Tyr
            1300                1305                1310        
Asp Ser Ser Arg Arg Glu Gln Met Ala Asp Met Ala Lys Ile Lys Leu
        1315                1320                1325            
Ser Val Leu Asn Ser Glu Asp Glu Leu Asn Arg Trp Asp Ser Gln Met
    1330                1335                1340                
Lys Gln Asp Ala Gly Arg Phe Asp Val Ser Phe Pro Asn Ser Ile Ile
1345                1350                1355                1360
Lys Arg Asp Ser Leu Arg Lys Arg Ser Val Arg Asp Leu Glu Pro Gly
                1365                1370                1375    
Glu Val Pro Ser Asp Ser Asp Glu Asp Gly Glu His Lys Ser His Ser
            1380                1385                1390        
Pro Arg Ala Ser Ala Leu Tyr Glu Ser Ser Arg Leu Ser Phe Leu Leu
        1395                1400                1405            
Arg Asp Arg Glu Asp Lys Leu Arg Glu Arg Asp Glu Arg Leu Ser Ser
    1410                1415                1420                
Ser Leu Glu Arg Asn Lys Phe Tyr Ser Phe Ala Leu Asp Lys Thr Ile
1425                1430                1435                1440
Thr Pro Asp Thr Lys Ala Leu Leu Glu Arg Ala Lys Ser Leu Ser Ser
                1445                1450                1455    
Ser Arg Glu Glu Asn Trp Ser Phe Leu Asp Trp Asp Ser Arg Phe Ala
            1460                1465                1470        
Asn Phe Arg Asn Asn Lys Asp Lys Glu Lys Val Asp Ser Ala Pro Arg
        1475                1480                1485            
Pro Ile Pro Ser Trp Tyr Met Lys Lys Lys Lys Ile Arg Thr Asp Ser
    1490                1495                1500                
Glu Gly Lys Met Asp Asp Lys Lys Glu Asp His Lys Glu Glu Glu Gln
1505                1510                1515                1520
Glu Arg Gln Glu Leu Phe Ala Ser Arg Phe Leu His Ser Ser Ile Phe
                1525                1530                1535    
Glu Gln Asp Ser Lys Arg Leu Gln His Leu Glu Arg Lys Glu Glu Asp
            1540                1545                1550        
Ser Asp Phe Ile Ser Gly Arg Ile Tyr Gly Lys Gln Thr Ser Glu Gly
        1555                1560                1565            
Ala Asn Ser Thr Thr Asp Ser Ile Gln Glu Pro Val Val Leu Phe His
    1570                1575                1580                
Ser Arg Phe Met Glu Leu Thr Arg Met Gln Gln Lys Glu Lys Glu Lys
1585                1590                1595                1600
Asp Gln Lys Pro Lys Glu Val Glu Lys Gln Glu Asp Thr Glu Asn His
                1605                1610                1615    
Pro Lys Thr Pro Glu Ser Ala Pro Glu Asn Lys Asp Ser Glu Leu Lys
            1620                1625                1630        
Thr Pro Pro Ser Val Gly Pro Pro Ser Val Thr Val Val Thr Leu Glu
        1635                1640                1645            
Ser Ala Pro Ser Ala Leu Glu Lys Thr Thr Gly Asp Lys Thr Val Glu
    1650                1655                1660                
Ala Pro Leu Val Thr Glu Glu Lys Thr Val Glu Pro Ala Thr Val Ser
1665                1670                1675                1680
Glu Glu Ala Lys Pro Ala Ser Glu Pro Ala Pro Ala Pro Val Glu Gln
                1685                1690                1695    
Leu Glu Gln Val Asp Leu Pro Pro Gly Ala Asp Pro Asp Lys Glu Ala
            1700                1705                1710        
Ala Met Met Pro Ala Gly Val Glu Glu Gly Ser Ser Gly Asp Gln Pro
        1715                1720                1725            
Pro Tyr Leu Asp Ala Lys Pro Pro Thr Pro Gly Ala Ser Phe Ser Gln
    1730                1735                1740                
Ala Glu Ser Asn Val Asp Pro Glu Pro Asp Ser Thr Gln Pro Leu Ser
1745                1750                1755                1760
Lys Pro Ala Gln Lys Ser Glu Glu Ala Asn Glu Pro Lys Ala Glu Lys
                1765                1770                1775    
Pro Asp Ala Thr Ala Asp Ala Glu Pro Asp Ala Asn Gln Lys Ala Glu
            1780                1785                1790        
Ala Ala Pro Glu Ser Gln Pro Pro Ala Ser Glu Asp Leu Glu Val Asp
        1795                1800                1805            
Pro Pro Val Ala Ala Lys Asp Lys Lys Pro Asn Lys Ser Lys Arg Ser
    1810                1815                1820                
Lys Thr Pro Val Gln Ala Ala Ala Val Ser Ile Val Glu Lys Pro Val
1825                1830                1835                1840
Thr Arg Lys Ser Glu Arg Ile Asp Arg Glu Lys Leu Lys Arg Ser Asn
                1845                1850                1855    
Ser Pro Arg Gly Glu Ala Gln Lys Leu Leu Glu Leu Lys Met Glu Ala
            1860                1865                1870        
Glu Lys Ile Thr Arg Thr Ala Ser Lys Asn Ser Ala Ala Asp Leu Glu
        1875                1880                1885            
His Pro Glu Pro Ser Leu Pro Leu Ser Arg Thr Arg Arg Arg Asn Val
    1890                1895                1900                
Arg Ser Val Tyr Ala Thr Met Gly Asp His Glu Asn Arg Ser Pro Val
1905                1910                1915                1920
Lys Glu Pro Val Glu Gln Pro Arg Val Thr Arg Lys Arg Leu Glu Arg
                1925                1930                1935    
Glu Leu Gln Glu Ala Ala Ala Val Pro Thr Thr Pro Arg Arg Gly Arg
            1940                1945                1950        
Pro Pro Lys Thr Arg Arg Arg Ala Asp Glu Glu Glu Glu Asn Glu Ala
        1955                1960                1965            
Lys Glu Pro Ala Glu Thr Leu Lys Pro Pro Glu Gly Trp Arg Ser Pro
    1970                1975                1980                
Arg Ser Gln Lys Thr Ala Ala Gly Gly Gly Pro Gln Gly Lys Lys Gly
1985                1990                1995                2000
Lys Asn Glu Pro Lys Val Asp Ala Thr Arg Pro Glu Ala Thr Thr Glu
                2005                2010                2015    
Val Gly Pro Gln Ile Gly Val Lys Glu Ser Ser Met Glu Pro Lys Ala
            2020                2025                2030        
Ala Glu Glu Glu Ala Gly Ser Glu Gln Lys Arg Asp Arg Lys Asp Ala
        2035                2040                2045            
Gly Thr Asp Lys Asn Pro Pro Glu Thr Ala Pro Val Glu Val Val Glu
    2050                2055                2060                
Lys Lys Pro Ala Pro Glu Lys Asn Ser Lys Ser Lys Arg Gly Arg Ser
2065                2070                2075                2080
Arg Asn Ser Arg Leu Ala Val Asp Lys Ser Ala Ser Leu Lys Asn Val
                2085                2090                2095    
Asp Ala Ala Val Ser Pro Arg Gly Ala Ala Ala Gln Ala Gly Glu Arg
            2100                2105                2110        
Glu Ser Gly Val Val Ala Val Ser Pro Glu Lys Ser Glu Ser Pro Gln
        2115                2120                2125            
Lys Glu Asp Gly Leu Ser Ser Gln Leu Lys Ser Asp Pro Val Asp Pro
    2130                2135                2140                
Asp Lys Glu Pro Glu Lys Glu Asp Val Ser Ala Ser Gly Pro Ser Pro
2145                2150                2155                2160
Glu Ala Thr Gln Leu Ala Lys Gln Met Glu Leu Glu Gln Ala Val Glu
                2165                2170                2175    
His Ile Ala Lys Leu Ala Glu Ala Ser Ala Ser Ala Ala Tyr Lys Ala
            2180                2185                2190        
Asp Ala Pro Glu Gly Leu Ala Pro Glu Asp Arg Asp Lys Pro Ala His
        2195                2200                2205            
Gln Ala Ser Glu Thr Glu Leu Ala Ala Ala Ile Gly Ser Ile Ile Asn
    2210                2215                2220                
Asp Ile Ser Gly Glu Pro Glu Asn Phe Pro Ala Pro Pro Pro Tyr Pro
2225                2230                2235                2240
Gly Glu Ser Gln Thr Asp Leu Gln Pro Pro Ala Gly Ala Gln Ala Leu
                2245                2250                2255    
Gln Pro Ser Glu Glu Gly Met Glu Thr Asp Glu Ala Val Ser Gly Ile
            2260                2265                2270        
Leu Glu Thr Glu Ala Ala Thr Glu Ser Ser Arg Pro Pro Val Asn Ala
        2275                2280                2285            
Pro Asp Pro Ser Ala Gly Pro Thr Asp Thr Lys Glu Ala Arg Gly Asn
    2290                2295                2300                
Ser Ser Glu Thr Ser His Ser Val Pro Glu Ala Lys Gly Ser Lys Glu
2305                2310                2315                2320
Val Glu Val Thr Leu Val Arg Lys Asp Lys Gly Arg Gln Lys Thr Thr
                2325                2330                2335    
Arg Ser Arg Arg Lys Arg Asn Thr Asn Lys Lys Val Val Ala Pro Val
            2340                2345                2350        
Glu Ser His Val Pro Glu Ser Asn Gln Ala Gln Gly Glu Ser Pro Ala
        2355                2360                2365            
Ala Asn Glu Gly Thr Thr Val Gln His Pro Glu Ala Pro Gln Glu Glu
    2370                2375                2380                
Lys Gln Ser Glu Lys Pro His Ser Thr Pro Pro Gln Ser Cys Thr Ser
2385                2390                2395                2400
Asp Leu Ser Lys Ile Pro Ser Thr Glu Asn Ser Ser Gln Glu Ile Ser
                2405                2410                2415    
Val Glu Glu Arg Thr Pro Thr Lys Ala Ser Val Pro Pro Asp Leu Pro
            2420                2425                2430        
Pro Pro Pro Gln Pro Ala Pro Val Asp Glu Glu Pro Gln Ala Arg Phe
        2435                2440                2445            
Arg Val His Ser Ile Ile Glu Ser Asp Pro Val Thr Pro Pro Ser Asp
    2450                2455                2460                
Pro Ser Ile Pro Ile Pro Thr Leu Pro Ser Val Thr Ala Ala Lys Leu
2465                2470                2475                2480
Ser Pro Pro Val Ala Ser Gly Gly Ile Pro His Gln Ser Pro Pro Thr
                2485                2490                2495    
Lys Val Thr Glu Trp Ile Thr Arg Gln Glu Glu Pro Arg Ala Gln Ser
            2500                2505                2510        
Thr Pro Ser Pro Ala Leu Pro Pro Asp Thr Lys Ala Ser Asp Val Asp
        2515                2520                2525            
Thr Ser Ser Ser Thr Leu Arg Lys Ile Leu Met Asp Pro Lys Tyr Val
    2530                2535                2540                
Ser Ala Thr Ser Val Thr Ser Thr Ser Val Thr Thr Ala Ile Ala Glu
2545                2550                2555                2560
Pro Val Ser Ala Ala Pro Cys Leu His Glu Ala Pro Pro Pro Pro Val
                2565                2570                2575    
Asp Ser Lys Lys Pro Leu Glu Glu Lys Thr Ala Pro Pro Val Thr Asn
            2580                2585                2590        
Asn Ser Glu Ile Gln Ala Ser Glu Val Leu Val Ala Ala Asp Lys Glu
        2595                2600                2605            
Lys Val Ala Pro Val Ile Ala Pro Lys Ile Thr Ser Val Ile Ser Arg
    2610                2615                2620                
Met Pro Val Ser Ile Asp Leu Glu Asn Ser Gln Lys Ile Thr Leu Ala
2625                2630                2635                2640
Lys Pro Ala Pro Gln Thr Leu Thr Gly Leu Val Ser Ala Leu Thr Gly
                2645                2650                2655    
Leu Val Asn Val Ser Leu Val Pro Val Asn Ala Leu Lys Gly Pro Val
            2660                2665                2670        
Lys Gly Ser Val Thr Thr Leu Lys Ser Leu Val Ser Thr Pro Ala Gly
        2675                2680                2685            
Pro Val Asn Val Leu Lys Gly Pro Val Asn Val Leu Thr Gly Pro Val
    2690                2695                2700                
Asn Val Leu Thr Thr Pro Val Asn Ala Thr Val Gly Thr Val Asn Ala
2705                2710                2715                2720
Ala Pro Gly Thr Val Asn Ala Ala Ala Ser Ala Val Asn Ala Thr Ala
                2725                2730                2735    
Ser Ala Val Thr Val Thr Ala Gly Ala Val Thr Ala Ala Ser Gly Gly
            2740                2745                2750        
Val Thr Ala Thr Thr Gly Thr Val Thr Met Ala Gly Ala Val Ile Ala
        2755                2760                2765            
Pro Ser Thr Lys Cys Lys Gln Arg Ala Ser Ala Asn Glu Asn Ser Arg
    2770                2775                2780                
Phe His Pro Gly Ser Met Pro Val Ile Asp Asp Arg Pro Ala Asp Ala
2785                2790                2795                2800
Gly Ser Gly Ala Gly Leu Arg Val Asn Thr Ser Glu Gly Val Val Leu
                2805                2810                2815    
Leu Ser Tyr Ser Gly Gln Lys Thr Glu Gly Pro Gln Arg Ile Ser Ala
            2820                2825                2830        
Lys Ile Ser Gln Ile Pro Pro Ala Ser Ala Met Asp Ile Glu Phe Gln
        2835                2840                2845            
Gln Ser Val Ser Lys Ser Gln Val Lys Pro Asp Ser Val Thr Ala Ser
    2850                2855                2860                
Gln Pro Pro Ser Lys Gly Pro Gln Ala Pro Ala Gly Tyr Ala Asn Val
2865                2870                2875                2880
Ala Thr His Ser Thr Leu Val Leu Thr Ala Gln Thr Tyr Asn Ala Ser
                2885                2890                2895    
Pro Val Ile Ser Ser Val Lys Ala Asp Arg Pro Ser Leu Glu Lys Pro
            2900                2905                2910        
Glu Pro Ile His Leu Ser Val Ser Thr Pro Val Thr Gln Gly Gly Thr
        2915                2920                2925            
Val Lys Val Leu Thr Gln Gly Ile Asn Thr Pro Pro Val Leu Val His
    2930                2935                2940                
Asn Gln Leu Val Leu Thr Pro Ser Ile Val Thr Thr Asn Lys Lys Leu
2945                2950                2955                2960
Ala Asp Pro Val Thr Leu Lys Ile Glu Thr Lys Val Leu Gln Pro Ala
                2965                2970                2975    
Asn Leu Gly Ser Thr Leu Thr Pro His His Pro Pro Ala Leu Pro Ser
            2980                2985                2990        
Lys Leu Pro Thr Glu Val Asn His Val Pro Ser Gly Pro Ser Ile Pro
        2995                3000                3005            
Ala Asp Arg Thr Val Ser His Leu Ala Ala Ala Lys Leu Asp Ala His
    3010                3015                3020                
Ser Pro Arg Pro Ser Gly Pro Gly Pro Ser Ser Phe Pro Arg Ala Ser
3025                3030                3035                3040
His Pro Ser Ser Thr Ala Ser Thr Ala Leu Ser Thr Asn Ala Thr Val
                3045                3050                3055    
Met Leu Ala Ala Gly Ile Pro Val Pro Gln Phe Ile Ser Ser Ile His
            3060                3065                3070        
Pro Glu Gln Ser Val Ile Met Pro Pro His Ser Ile Thr Gln Thr Val
        3075                3080                3085            
Ser Leu Ser His Leu Ser Gln Gly Glu Val Arg Met Asn Thr Pro Thr
    3090                3095                3100                
Leu Pro Ser Ile Thr Tyr Ser Ile Arg Pro Glu Ala Leu His Ser Pro
3105                3110                3115                3120
Arg Ala Pro Leu Gln Pro Gln Gln Ile Glu Val Arg Ala Pro Gln Arg
                3125                3130                3135    
Ala Ser Thr Pro Gln Pro Ala Pro Ala Gly Val Pro Ala Leu Ala Ser
            3140                3145                3150        
Gln His Pro Pro Glu Glu Glu Val His Tyr His Leu Pro Val Ala Arg
        3155                3160                3165            
Ala Thr Ala Pro Val Gln Ser Glu Val Leu Val Met Gln Ser Glu Tyr
    3170                3175                3180                
Arg Leu His Pro Tyr Thr Val Pro Arg Asp Val Arg Ile Met Val His
3185                3190                3195                3200
Pro His Val Thr Ala Val Ser Glu Gln Pro Arg Ala Ala Asp Gly Val
                3205                3210                3215    
Val Lys Val Pro Pro Ala Ser Lys Ala Pro Gln Gln Pro Gly Lys Glu
            3220                3225                3230        
Ala Ala Lys Thr Pro Asp Ala Lys Ala Ala Pro Thr Pro Thr Pro Ala
        3235                3240                3245            
Pro Val Pro Val Pro Val Pro Leu Pro Ala Pro Ala Pro Ala Pro His
    3250                3255                3260                
Gly Glu Ala Arg Ile Leu Thr Val Thr Pro Ser Asn Gln Leu Gln Gly
3265                3270                3275                3280
Leu Pro Leu Thr Pro Pro Val Val Val Thr His Gly Val Gln Ile Val
                3285                3290                3295    
His Ser Ser Gly Glu Leu Phe Gln Glu Tyr Arg Tyr Gly Asp Ile Arg
            3300                3305                3310        
Thr Tyr His Pro Pro Ala Gln Leu Thr His Thr Gln Phe Pro Ala Ala
        3315                3320                3325            
Ser Ser Val Gly Leu Pro Ser Arg Thr Lys Thr Ala Ala Gln Gly Pro
    3330                3335                3340                
Pro Pro Glu Gly Glu Pro Leu Gln Pro Pro Gln Pro Val Gln Ser Thr
3345                3350                3355                3360
Gln Pro Ala Gln Pro Ala Pro Pro Cys Pro Pro Ser Gln Leu Gly Gln
                3365                3370                3375    
Pro Gly Gln Pro Pro Ser Ser Lys Met Pro Gln Val Ser Gln Glu Ala
            3380                3385                3390        
Lys Gly Thr Gln Thr Gly Val Glu Gln Pro Arg Leu Pro Ala Gly Pro
        3395                3400                3405            
Ala Asn Arg Pro Pro Glu Pro His Thr Gln Val Gln Arg Ala Gln Ala
    3410                3415                3420                
Glu Thr Gly Pro Thr Ser Phe Pro Ser Pro Val Ser Val Ser Met Lys
3425                3430                3435                3440
Pro Asp Leu Pro Val Ser Leu Pro Thr Gln Thr Ala Pro Lys Gln Pro
                3445                3450                3455    
Leu Phe Val Pro Thr Thr Ser Gly Pro Ser Thr Pro Pro Gly Leu Val
            3460                3465                3470        
Leu Pro His Thr Glu Phe Gln Pro Ala Pro Lys Gln Asp Ser Ser Pro
        3475                3480                3485            
His Leu Thr Ser Gln Arg Pro Val Asp Met Val Gln Leu Leu Lys Lys
    3490                3495                3500                
Tyr Pro Ile Val Trp Gln Gly Leu Leu Ala Leu Lys Asn Asp Thr Ala
3505                3510                3515                3520
Ala Val Gln Leu His Phe Val Ser Gly Asn Asn Val Leu Ala His Arg
                3525                3530                3535    
Ser Leu Pro Leu Ser Glu Gly Gly Pro Pro Leu Arg Ile Ala Gln Arg
            3540                3545                3550        
Met Arg Leu Glu Ala Thr Gln Leu Glu Gly Val Ala Arg Arg Met Thr
        3555                3560                3565            
Val Glu Thr Asp Tyr Cys Leu Leu Leu Ala Leu Pro Cys Gly Arg Asp
    3570                3575                3580                
Gln Glu Asp Val Val Ser Gln Thr Glu Ser Leu Lys Ala Ala Phe Ile
3585                3590                3595                3600
Thr Tyr Leu Gln Ala Lys Gln Ala Ala Gly Ile Ile Asn Val Pro Asn
                3605                3610                3615    
Pro Gly Ser Asn Gln Pro Ala Tyr Val Leu Gln Ile Phe Pro Pro Cys
            3620                3625                3630        
Glu Phe Ser Glu Ser His Leu Ser Arg Leu Ala Pro Asp Leu Leu Ala
        3635                3640                3645            
Ser Ile Ser Asn Ile Ser Pro His Leu Met Ile Val Ile Ala Ser Val
    3650                3655                3660                


<210> 2288
<211> 154
<212> PRT
<213> Homo sapiens

<400> 2288
Met Gly Ser Leu Ser Gly Leu Arg Leu Ala Ala Gly Ser Cys Phe Arg
 1               5                  10                  15      
Leu Cys Glu Arg Asp Val Ser Ser Ser Leu Arg Leu Thr Arg Ser Ser
            20                  25                  30          
Asp Leu Lys Arg Ile Asn Gly Phe Cys Thr Lys Pro Gln Glu Ser Pro
        35                  40                  45              
Gly Val Pro Ser Arg Thr Tyr Asn Arg Val Pro Leu His Lys Pro Thr
    50                  55                  60                  
Asp Trp Gln Lys Lys Ile Leu Ile Trp Ser Gly Arg Phe Lys Lys Glu
65                  70                  75                  80  
Asp Glu Ile Pro Glu Thr Val Ser Leu Glu Met Leu Asp Ala Ala Lys
                85                  90                  95      
Asn Lys Met Arg Val Lys Ile Ser Tyr Leu Met Ile Ala Leu Thr Val
            100                 105                 110         
Val Gly Cys Ile Phe Met Val Ile Glu Gly Lys Lys Ala Ala Gln Arg
        115                 120                 125             
His Glu Thr Leu Thr Ser Leu Asn Leu Glu Lys Lys Ala Arg Leu Lys
    130                 135                 140                 
Glu Glu Ala Ala Met Lys Ala Lys Thr Glu
145                 150                 


<210> 2289
<211> 121
<212> PRT
<213> Homo sapiens

<400> 2289
Met Phe Gly Ala Cys Tyr Lys Gln Pro Leu Lys Pro Ser Gly Ser Glu
 1               5                  10                  15      
Pro Pro Ala Glu Glu Cys Arg Met Thr Pro Arg His Ala Gly Cys Asp
            20                  25                  30          
Val Thr Glu Met Gln Arg Ile Leu Ser Gln Pro Thr Phe Thr Glu His
        35                  40                  45              
Leu Leu Arg Ala Val Cys Leu Val Asn Gly Lys Gly Ser Leu Ser Arg
    50                  55                  60                  
Pro Gln Glu Ser Ile Leu Gly Ser Leu Ala Arg Lys Asn Leu Arg Arg
65                  70                  75                  80  
Ile His Arg Val Ser Leu Val Met Cys Val Arg Pro Leu Ser Pro Ser
                85                  90                  95      
Lys Ala Ile Ile Ser Pro Val Thr Cys Met Tyr Thr Ser Arg Trp Pro
            100                 105                 110         
Glu Ala Ser Glu Glu Ser Gln Lys Lys
        115                 120     


<210> 2290
<211> 1204
<212> PRT
<213> Homo sapiens

<400> 2290
Met Val Gly Val Leu Ala Met Ala Ala Ala Ala Ala Pro Pro Pro Val
 1               5                  10                  15      
Lys Asp Cys Glu Ile Glu Pro Cys Lys Lys Arg Lys Lys Asp Asp Asp
            20                  25                  30          
Thr Ser Thr Cys Lys Thr Ile Thr Lys Tyr Leu Ser Pro Leu Gly Lys
        35                  40                  45              
Thr Arg Asp Arg Val Phe Ala Pro Pro Lys Pro Ser Asn Ile Leu Asp
    50                  55                  60                  
Tyr Phe Arg Lys Thr Ser Pro Thr Asn Glu Lys Thr Gln Leu Gly Lys
65                  70                  75                  80  
Glu Cys Lys Ile Lys Ser Pro Glu Ser Val Pro Val Asp Ser Asn Lys
                85                  90                  95      
Asp Cys Thr Thr Pro Leu Glu Met Phe Ser Asn Val Glu Phe Lys Lys
            100                 105                 110         
Lys Arg Lys Arg Val Asn Leu Ser His Gln Leu Asn Asn Ile Lys Thr
        115                 120                 125             
Glu Asn Glu Ala Pro Ile Glu Ile Ser Ser Asp Asp Ser Lys Glu Asp
    130                 135                 140                 
Tyr Ser Leu Asn Asn Asp Phe Val Glu Ser Ser Thr Ser Val Leu Arg
145                 150                 155                 160 
Tyr Lys Lys Gln Val Glu Val Leu Ala Glu Asn Ile Gln Asp Thr Lys
                165                 170                 175     
Ser Gln Pro Asn Thr Met Thr Ser Leu Gln Asn Ser Lys Lys Val Asn
            180                 185                 190         
Pro Lys Gln Gly Thr Thr Lys Asn Asp Phe Lys Lys Leu Arg Lys Arg
        195                 200                 205             
Lys Cys Arg Asp Val Val Asp Leu Ser Glu Ser Leu Pro Leu Ala Glu
    210                 215                 220                 
Glu Leu Asn Leu Leu Lys Lys Asp Gly Lys Asp Thr Lys Gln Met Glu
225                 230                 235                 240 
Asn Thr Thr Ser His Ala Asn Ser Arg Asp Asn Val Thr Glu Ala Ala
                245                 250                 255     
Gln Leu Asn Asp Ser Ile Ile Thr Val Ser Tyr Glu Glu Phe Leu Lys
            260                 265                 270         
Ser His Lys Glu Asn Lys Val Glu Glu Ile Pro Asp Ser Thr Met Ser
        275                 280                 285             
Ile Cys Val Pro Ser Glu Thr Val Asp Glu Ile Val Lys Ser Gly Tyr
    290                 295                 300                 
Ile Ser Glu Ser Glu Asn Ser Glu Ile Ser Gln Gln Val Arg Phe Lys
305                 310                 315                 320 
Thr Val Thr Val Leu Ala Gln Val His Pro Ile Pro Pro Lys Lys Thr
                325                 330                 335     
Gly Lys Ile Pro Arg Ile Phe Leu Lys Gln Lys Gln Phe Glu Met Glu
            340                 345                 350         
Asn Ser Leu Ser Asp Pro Glu Asn Glu Gln Thr Val Gln Lys Arg Lys
        355                 360                 365             
Ser Asn Val Val Ile Gln Glu Glu Glu Leu Glu Leu Ala Val Leu Glu
    370                 375                 380                 
Ala Gly Ser Ser Glu Ala Val Lys Pro Lys Cys Thr Leu Glu Glu Arg
385                 390                 395                 400 
Gln Gln Phe Met Lys Ala Phe Arg Gln Pro Ala Ser Asp Ala Leu Lys
                405                 410                 415     
Asn Gly Val Lys Lys Ser Ser Asp Lys Gln Lys Asp Leu Asn Glu Lys
            420                 425                 430         
Cys Leu Tyr Glu Val Gly Arg Asp Asp Asn Ser Lys Lys Ile Met Glu
        435                 440                 445             
Asn Ser Gly Ile Gln Met Val Ser Lys Asn Gly Asn Leu Gln Leu His
    450                 455                 460                 
Thr Asp Lys Gly Ser Phe Leu Lys Glu Lys Asn Lys Lys Leu Lys Lys
465                 470                 475                 480 
Lys Asn Lys Lys Thr Leu Asp Thr Gly Ala Ile Pro Gly Lys Asn Arg
                485                 490                 495     
Glu Gly Asn Thr Gln Lys Lys Glu Thr Thr Phe Phe Leu Lys Glu Lys
            500                 505                 510         
Gln Tyr Gln Asn Arg Met Ser Leu Arg Gln Arg Lys Thr Glu Phe Phe
        515                 520                 525             
Lys Ser Ser Thr Leu Phe Asn Asn Glu Ser Leu Val Tyr Glu Asp Ile
    530                 535                 540                 
Ala Asn Asp Asp Leu Leu Lys Val Ser Ser Leu Cys Asn Asn Asn Lys
545                 550                 555                 560 
Leu Ser Arg Lys Thr Ser Ile Pro Val Lys Asp Ile Lys Leu Thr Gln
                565                 570                 575     
Ser Lys Ala Glu Ser Glu Ala Ser Leu Leu Asn Val Ser Thr Pro Lys
            580                 585                 590         
Ser Thr Arg Arg Ser Gly Arg Ile Ser Ser Thr Pro Thr Thr Glu Thr
        595                 600                 605             
Ile Arg Gly Ile Asp Ser Asp Asp Val Gln Asp Asn Ser Gln Leu Lys
    610                 615                 620                 
Ala Ser Thr Gln Lys Ala Ala Asn Leu Ser Glu Lys His Ser Leu Tyr
625                 630                 635                 640 
Thr Ala Glu Leu Ile Thr Val Pro Phe Asp Ser Glu Ser Pro Ile Arg
                645                 650                 655     
Met Lys Phe Thr Arg Ile Ser Thr Pro Lys Lys Ser Lys Lys Lys Ser
            660                 665                 670         
Asn Lys Arg Ser Glu Lys Ser Glu Ala Thr Asp Gly Gly Phe Thr Ser
        675                 680                 685             
Gln Ile Arg Lys Ala Ser Asn Thr Ser Lys Asn Ile Ser Lys Ala Lys
    690                 695                 700                 
Gln Leu Ile Glu Lys Ala Lys Ala Leu His Ile Ser Arg Ser Lys Val
705                 710                 715                 720 
Thr Glu Glu Ile Ala Ile Pro Leu Arg Arg Ser Ser Arg His Gln Thr
                725                 730                 735     
Leu Pro Glu Arg Lys Lys Leu Ser Glu Thr Glu Asp Ser Val Ile Ile
            740                 745                 750         
Ile Asp Ser Ser Pro Thr Ala Leu Lys His Pro Glu Lys Asn Gln Lys
        755                 760                 765             
Lys Leu Gln Cys Leu Asn Asp Val Leu Gly Lys Lys Leu Asn Thr Ser
    770                 775                 780                 
Thr Lys Asn Val Pro Gly Lys Met Lys Val Ala Pro Leu Phe Leu Val
785                 790                 795                 800 
Arg Lys Ala Gln Lys Ala Ala Asp Pro Val Pro Ser Phe Asp Glu Ser
                805                 810                 815     
Ser Gln Asp Thr Ser Glu Lys Ser Gln Asp Cys Asp Val Gln Cys Lys
            820                 825                 830         
Ala Lys Arg Asp Phe Leu Met Ser Gly Leu Pro Asp Leu Leu Lys Arg
        835                 840                 845             
Gln Ile Ala Lys Lys Ala Ala Ala Leu Asp Val Tyr Asn Ala Val Ser
    850                 855                 860                 
Thr Ser Phe Gln Arg Val Val His Val Gln Gln Lys Asp Asp Gly Cys
865                 870                 875                 880 
Cys Leu Trp His Leu Lys Pro Pro Ser Cys Pro Leu Leu Thr Lys Phe
                885                 890                 895     
Lys Glu Leu Asn Thr Lys Val Ile Asp Leu Ser Lys Cys Gly Ile Ala
            900                 905                 910         
Leu Gly Glu Phe Ser Thr Leu Asn Ser Lys Leu Lys Ser Gly Asn Ser
        915                 920                 925             
Ala Ala Val Phe Met Arg Thr Arg Lys Glu Phe Thr Glu Glu Val Arg
    930                 935                 940                 
Asn Leu Leu Leu Glu Glu Ile Arg Trp Ser Asn Pro Glu Phe Ser Leu
945                 950                 955                 960 
Lys Lys Tyr Phe Pro Leu Leu Leu Lys Lys Gln Ile Glu His Gln Val
                965                 970                 975     
Leu Ser Ser Glu Cys His Ser Lys Gln Glu Leu Glu Ala Asp Val Ser
            980                 985                 990         
His Lys Glu Thr Lys Arg Lys Leu Val Glu Ala Glu Asn Ser Lys Ser
        995                 1000                1005            
Lys Arg Lys Lys Pro Asn Glu Tyr Ser Lys Asn Leu Glu Lys Thr Asn
    1010                1015                1020                
Arg Lys Ser Glu Glu Leu Ser Lys Arg Asn Asn Ser Ser Gly Ile Lys
1025                1030                1035                1040
Leu Asp Ser Ser Lys Asp Ser Gly Thr Glu Asp Met Leu Trp Thr Glu
                1045                1050                1055    
Lys Tyr Gln Pro Gln Thr Ala Ser Glu Leu Ile Gly Asn Glu Leu Ala
            1060                1065                1070        
Ile Lys Lys Leu His Ser Trp Leu Lys Asp Trp Lys Arg Arg Ala Glu
        1075                1080                1085            
Leu Glu Glu Arg Gln Asn Leu Lys Gly Lys Arg Asp Glu Lys His Glu
    1090                1095                1100                
Asp Phe Ser Gly Gly Ile Asp Phe Lys Gly Ser Ser Asp Asp Glu Glu
1105                1110                1115                1120
Glu Ser Arg Leu Cys Asn Thr Val Leu Ile Thr Gly Pro Thr Gly Val
                1125                1130                1135    
Gly Lys Thr Ala Ala Val Tyr Ala Cys Ala Gln Glu Leu Gly Phe Lys
            1140                1145                1150        
Ile Phe Glu Val Asn Ala Ser Ser Gln Arg Ser Gly Arg Gln Ile Leu
        1155                1160                1165            
Ser Gln Leu Lys Glu Ala Thr Gln Ser His Gln Val Asp Lys Gln Gly
    1170                1175                1180                
Val Asn Ser Gln Lys Pro Cys Phe Phe Asn Ser Tyr Tyr Ile Gly Lys
1185                1190                1195                1200
Ser Pro Ser Lys
                


<210> 2291
<211> 6620
<212> PRT
<213> Homo sapiens

<400> 2291
Met Asp Gln Pro Gln Phe Ser Gly Ala Pro Arg Phe Leu Thr Arg Pro
 1               5                  10                  15      
Lys Ala Phe Val Val Ser Val Gly Lys Asp Ala Thr Leu Ser Cys Gln
            20                  25                  30          
Ile Val Gly Asn Pro Thr Pro Gln Val Ser Trp Glu Lys Asp Gln Gln
        35                  40                  45              
Pro Val Thr Ala Gly Ala Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu
    50                  55                  60                  
Tyr Arg Leu Thr Ile Leu Asp Leu Ala Leu Gly Asp Ser Gly Gln Tyr
65                  70                  75                  80  
Val Cys Arg Ala Arg Asn Ala Ile Gly Glu Ala Phe Ala Ala Val Gly
                85                  90                  95      
Leu Gln Val Asp Ala Glu Ala Ala Cys Ala Glu Gln Ala Pro His Phe
            100                 105                 110         
Leu Leu Arg Pro Thr Ser Ile Arg Val Arg Glu Gly Ser Glu Ala Thr
        115                 120                 125             
Phe Arg Cys Arg Val Gly Gly Ser Pro Arg Pro Ala Val Ser Trp Ser
    130                 135                 140                 
Lys Asp Gly Arg Arg Leu Gly Glu Pro Asp Gly Pro Arg Val Arg Val
145                 150                 155                 160 
Glu Glu Leu Gly Glu Ala Ser Ala Leu Arg Ile Arg Ala Ala Arg Pro
                165                 170                 175     
Arg Asp Gly Gly Thr Tyr Glu Val Arg Ala Glu Asn Pro Leu Gly Ala
            180                 185                 190         
Ala Ser Ala Ala Ala Ala Leu Val Val Asp Ser Asp Ala Ala Asp Thr
        195                 200                 205             
Ala Ser Arg Pro Gly Thr Ser Thr Ala Ala Leu Leu Ala His Leu Gln
    210                 215                 220                 
Arg Arg Arg Glu Ala Met Arg Ala Glu Gly Ala Pro Ala Ser Pro Pro
225                 230                 235                 240 
Ser Thr Gly Thr Arg Thr Cys Thr Val Thr Glu Gly Lys His Ala Arg
                245                 250                 255     
Leu Ser Cys Tyr Val Thr Gly Glu Pro Lys Pro Glu Thr Val Trp Lys
            260                 265                 270         
Lys Asp Gly Gln Leu Val Thr Glu Gly Arg Arg His Val Val Tyr Glu
        275                 280                 285             
Asp Ala Gln Glu Asn Phe Val Leu Lys Ile Leu Phe Cys Lys Gln Ser
    290                 295                 300                 
Asp Arg Gly Leu Tyr Thr Cys Thr Ala Ser Asn Leu Val Gly Gln Thr
305                 310                 315                 320 
Tyr Ser Ser Val Leu Val Val Val Arg Glu Pro Ala Val Pro Phe Lys
                325                 330                 335     
Lys Arg Leu Gln Asp Leu Glu Val Arg Glu Lys Glu Ser Ala Thr Phe
            340                 345                 350         
Leu Cys Glu Val Pro Gln Pro Ser Thr Glu Ala Ala Trp Phe Lys Glu
        355                 360                 365             
Glu Thr Arg Leu Trp Ala Ser Ala Lys Tyr Gly Ile Glu Glu Glu Gly
    370                 375                 380                 
Thr Glu Arg Arg Leu Thr Val Arg Asn Val Ser Ala Asp Asp Asp Ala
385                 390                 395                 400 
Val Tyr Ile Cys Glu Thr Pro Glu Gly Ser Arg Thr Val Ala Glu Leu
                405                 410                 415     
Ala Val Gln Gly Asn Leu Leu Arg Lys Leu Pro Arg Lys Thr Ala Val
            420                 425                 430         
Arg Val Gly Asp Thr Ala Met Phe Cys Val Glu Leu Ala Val Pro Val
        435                 440                 445             
Gly Pro Val His Trp Leu Arg Asn Gln Glu Glu Val Val Ala Gly Gly
    450                 455                 460                 
Arg Val Ala Ile Ser Ala Glu Gly Thr Arg His Thr Leu Thr Ile Ser
465                 470                 475                 480 
Gln Cys Cys Leu Glu Asp Val Gly Gln Val Ala Phe Met Ala Gly Asp
                485                 490                 495     
Cys Gln Thr Ser Thr Arg Phe Cys Val Ser Ala Pro Arg Lys Pro Pro
            500                 505                 510         
Leu Gln Pro Pro Val Asp Pro Val Val Lys Ala Arg Met Glu Ser Ser
        515                 520                 525             
Val Ile Leu Ser Trp Ser Pro Pro Pro His Gly Glu Arg Pro Val Thr
    530                 535                 540                 
Ile Asp Gly Tyr Leu Val Glu Lys Lys Lys Leu Gly Thr Tyr Thr Trp
545                 550                 555                 560 
Ile Arg Cys His Glu Ala Glu Trp Val Ala Thr Pro Glu Leu Thr Val
                565                 570                 575     
Ala Asp Val Ala Glu Glu Gly Asn Phe Gln Phe Arg Val Ser Ala Leu
            580                 585                 590         
Asn Ser Phe Gly Gln Ser Pro Tyr Leu Glu Phe Pro Gly Thr Val His
        595                 600                 605             
Leu Ala Pro Lys Leu Ala Val Arg Thr Pro Leu Lys Ala Val Gln Ala
    610                 615                 620                 
Val Glu Gly Gly Glu Val Thr Phe Ser Val Asp Leu Thr Val Ala Ser
625                 630                 635                 640 
Ala Gly Glu Trp Phe Leu Asp Gly Gln Ala Leu Lys Ala Ser Ser Val
                645                 650                 655     
Tyr Glu Ile His Cys Asp Arg Thr Arg His Thr Leu Thr Ile Arg Glu
            660                 665                 670         
Val Pro Ala Ser Leu His Gly Ala Gln Leu Lys Phe Val Ala Asn Gly
        675                 680                 685             
Ile Glu Ser Ser Ile Arg Met Glu Val Arg Ala Ala Pro Gly Leu Thr
    690                 695                 700                 
Ala Asn Lys Pro Pro Ala Ala Ala Ala Arg Glu Val Leu Ala Arg Leu
705                 710                 715                 720 
His Glu Glu Ala Gln Leu Leu Ala Glu Leu Ser Asp Gln Ala Ala Ala
                725                 730                 735     
Val Thr Trp Leu Lys Asp Gly Arg Thr Leu Ser Pro Gly Pro Lys Tyr
            740                 745                 750         
Glu Val Gln Ala Ser Ala Gly Arg Arg Val Leu Leu Val Arg Asp Val
        755                 760                 765             
Ala Arg Asp Asp Ala Gly Leu Tyr Glu Cys Val Ser Arg Gly Gly Arg
    770                 775                 780                 
Ile Ala Tyr Gln Leu Ser Val Gln Gly Leu Ala Arg Phe Leu His Lys
785                 790                 795                 800 
Asp Met Ala Gly Ser Cys Val Asp Ala Val Ala Gly Gly Pro Ala Gln
                805                 810                 815     
Phe Glu Cys Glu Thr Ser Glu Ala His Val His Val His Trp Tyr Lys
            820                 825                 830         
Asp Gly Met Glu Leu Gly His Ser Gly Glu Arg Phe Leu Gln Glu Asp
        835                 840                 845             
Val Gly Thr Arg His Arg Leu Val Ala Ala Thr Val Thr Arg Gln Asp
    850                 855                 860                 
Glu Gly Thr Tyr Ser Cys Arg Val Gly Glu Asp Ser Val Asp Phe Arg
865                 870                 875                 880 
Leu Arg Val Ser Glu Pro Lys Val Val Phe Ala Lys Glu Gln Leu Ala
                885                 890                 895     
Arg Arg Lys Leu Gln Ala Glu Ala Gly Ala Ser Ala Thr Leu Ser Cys
            900                 905                 910         
Glu Val Ala Gln Ala Gln Thr Glu Val Thr Trp Tyr Lys Asp Gly Lys
        915                 920                 925             
Lys Leu Ser Ser Ser Ser Lys Val Cys Met Glu Ala Thr Gly Cys Thr
    930                 935                 940                 
Arg Arg Leu Val Val Gln Gln Ala Gly Gln Ala Asp Ala Gly Glu Tyr
945                 950                 955                 960 
Ser Cys Glu Ala Gly Gly Gln Arg Leu Ser Phe His Leu Asp Val Lys
                965                 970                 975     
Glu Pro Lys Val Val Phe Ala Lys Asp Gln Val Ala His Ser Glu Val
            980                 985                 990         
Gln Ala Glu Ala Gly Ala Asn Ala Thr Leu Ser Cys Glu Val Ala Gln
        995                 1000                1005            
Ala Gln Ala Glu Val Met Trp Tyr Lys Asp Gly Lys Lys Leu Ser Ser
    1010                1015                1020                
Ser Leu Lys Val His Val Glu Ala Lys Gly Cys Arg Arg Arg Leu Val
1025                1030                1035                1040
Val Gln Gln Ala Gly Lys Thr Asp Ala Gly Asp Tyr Ser Cys Glu Ala
                1045                1050                1055    
Arg Gly Gln Arg Val Ser Phe Arg Leu His Ile Thr Glu Pro Lys Met
            1060                1065                1070        
Met Phe Ala Lys Glu Gln Ser Val His Asn Glu Val Gln Ala Glu Ala
        1075                1080                1085            
Gly Ala Ser Ala Met Leu Ser Cys Glu Val Ala Gln Ala Gln Thr Glu
    1090                1095                1100                
Val Thr Trp Tyr Lys Asp Gly Lys Lys Leu Ser Ser Ser Ser Lys Val
1105                1110                1115                1120
Gly Met Glu Val Lys Gly Cys Thr Arg Arg Leu Val Leu Pro Gln Ala
                1125                1130                1135    
Gly Lys Ala Asp Ala Gly Glu Tyr Ser Cys Glu Ala Gly Gly Gln Arg
            1140                1145                1150        
Val Ser Phe His Leu His Ile Thr Glu Pro Lys Gly Val Phe Ala Lys
        1155                1160                1165            
Glu Gln Ser Val His Asn Glu Val Gln Ala Glu Ala Gly Thr Thr Ala
    1170                1175                1180                
Met Leu Ser Cys Glu Val Ala Gln Pro Gln Thr Glu Val Thr Trp Tyr
1185                1190                1195                1200
Lys Asp Gly Lys Lys Leu Ser Ser Ser Ser Lys Val Arg Met Glu Val
                1205                1210                1215    
Lys Gly Cys Thr Arg Arg Leu Val Val Gln Gln Val Gly Lys Ala Asp
            1220                1225                1230        
Ala Gly Glu Tyr Ser Cys Glu Ala Gly Gly Gln Arg Val Ser Phe Gln
        1235                1240                1245            
Leu His Ile Thr Glu Pro Lys Ala Val Phe Ala Lys Glu Gln Leu Val
    1250                1255                1260                
His Asn Glu Val Arg Thr Glu Ala Gly Ala Ser Ala Thr Leu Ser Cys
1265                1270                1275                1280
Glu Val Ala Gln Ala Gln Thr Glu Val Thr Trp Tyr Lys Asp Gly Lys
                1285                1290                1295    
Lys Leu Ser Ser Ser Ser Lys Val Arg Ile Glu Ala Ala Gly Cys Met
            1300                1305                1310        
Arg Gln Leu Val Val Gln Gln Ala Gly Gln Ala Asp Ala Gly Glu Tyr
        1315                1320                1325            
Thr Cys Glu Ala Gly Gly Gln Arg Leu Ser Phe His Leu Asp Val Ser
    1330                1335                1340                
Glu Pro Lys Ala Val Phe Ala Lys Glu Gln Leu Ala His Arg Lys Val
1345                1350                1355                1360
Gln Ala Glu Ala Gly Ala Ile Ala Thr Leu Ser Cys Glu Val Ala Gln
                1365                1370                1375    
Ala Gln Thr Glu Val Thr Trp Tyr Lys Asp Gly Lys Lys Leu Ser Ser
            1380                1385                1390        
Ser Ser Lys Val Arg Met Glu Ala Val Gly Cys Thr Arg Arg Leu Val
        1395                1400                1405            
Val Gln Gln Ala Cys Gln Ala Asp Thr Gly Glu Tyr Ser Cys Glu Ala
    1410                1415                1420                
Gly Gly Gln Arg Leu Ser Phe Ser Leu Asp Val Ala Glu Pro Lys Val
1425                1430                1435                1440
Val Phe Ala Lys Glu Gln Pro Val His Arg Glu Val Gln Ala Gln Ala
                1445                1450                1455    
Gly Ala Ser Thr Thr Leu Ser Cys Glu Val Ala Gln Ala Gln Thr Glu
            1460                1465                1470        
Val Met Trp Tyr Lys Asp Gly Lys Lys Leu Ser Phe Ser Ser Lys Val
        1475                1480                1485            
Arg Met Glu Ala Val Gly Cys Thr Arg Arg Leu Val Val Gln Gln Ala
    1490                1495                1500                
Gly Gln Ala Asp Ala Gly Glu Tyr Ser Cys Glu Ala Gly Ser Gln Arg
1505                1510                1515                1520
Leu Ser Phe His Leu His Val Ala Glu Pro Lys Ala Val Phe Ala Lys
                1525                1530                1535    
Glu Gln Pro Ala Ser Arg Glu Val Gln Ala Glu Ala Gly Thr Ser Ala
            1540                1545                1550        
Thr Leu Ser Cys Glu Val Ala Gln Ala Gln Thr Glu Val Thr Trp Tyr
        1555                1560                1565            
Lys Asp Gly Lys Lys Leu Ser Ser Ser Ser Lys Val Arg Met Glu Ala
    1570                1575                1580                
Val Gly Cys Thr Arg Arg Leu Val Val Gln Glu Ala Gly Gln Ala Asp
1585                1590                1595                1600
Ala Gly Glu Tyr Ser Cys Lys Ala Gly Asp Gln Arg Leu Ser Phe His
                1605                1610                1615    
Leu His Val Ala Glu Pro Lys Val Val Phe Ala Lys Glu Gln Pro Ala
            1620                1625                1630        
His Arg Glu Val Gln Ala Glu Ala Gly Ala Ser Ala Thr Leu Ser Cys
        1635                1640                1645            
Glu Val Ala Gln Ala Gln Thr Glu Val Thr Trp Tyr Lys Asp Gly Lys
    1650                1655                1660                
Lys Leu Ser Ser Ser Ser Lys Val Arg Val Glu Ala Val Gly Cys Thr
1665                1670                1675                1680
Arg Arg Leu Val Val Gln Gln Ala Gly Gln Ala Asp Ala Gly Glu Tyr
                1685                1690                1695    
Ser Cys Glu Ala Gly Gly Gln Arg Leu Ser Phe Arg Leu His Val Ala
            1700                1705                1710        
Glu Leu Glu Pro Gln Ile Ser Glu Arg Pro Cys Arg Arg Glu Pro Leu
        1715                1720                1725            
Val Val Lys Glu His Glu Asp Ile Ile Leu Thr Ala Thr Leu Ala Thr
    1730                1735                1740                
Pro Ser Ala Ala Thr Val Thr Trp Leu Lys Asp Gly Val Glu Ile Arg
1745                1750                1755                1760
Arg Ser Lys Arg His Glu Thr Ala Ser Gln Gly Asp Thr His Thr Leu
                1765                1770                1775    
Thr Val His Gly Ala Gln Val Leu Asp Ser Ala Ile Tyr Ser Cys Arg
            1780                1785                1790        
Val Gly Ala Glu Gly Gln Asp Phe Pro Val Gln Val Glu Glu Val Ala
        1795                1800                1805            
Ala Lys Phe Cys Arg Leu Leu Glu Pro Val Cys Gly Glu Leu Gly Gly
    1810                1815                1820                
Thr Val Thr Leu Ala Cys Glu Leu Ser Pro Ala Cys Ala Glu Val Val
1825                1830                1835                1840
Trp Arg Cys Gly Asn Thr Gln Pro Arg Val Gly Lys Arg Phe Gln Met
                1845                1850                1855    
Val Ala Glu Gly Pro Val Arg Ser Leu Thr Val Leu Gly Leu Arg Ala
            1860                1865                1870        
Glu Asp Ala Gly Glu Tyr Val Cys Glu Ser Arg Asp Asp His Thr Ser
        1875                1880                1885            
Ala Gln Leu Thr Val Ser Val Pro Arg Val Val Lys Phe Met Ser Gly
    1890                1895                1900                
Leu Ser Thr Val Val Ala Glu Glu Gly Gly Glu Ala Thr Phe Gln Cys
1905                1910                1915                1920
Val Val Ser Pro Ser Asp Val Ala Val Val Trp Phe Arg Asp Gly Ala
                1925                1930                1935    
Leu Leu Gln Pro Ser Glu Lys Phe Ala Ile Ser Gln Ser Gly Ala Ser
            1940                1945                1950        
His Ser Leu Thr Ile Ser Asp Leu Val Leu Glu Asp Ala Gly Gln Ile
        1955                1960                1965            
Thr Val Glu Ala Glu Gly Ala Ser Ser Ser Ala Ala Leu Arg Val Arg
    1970                1975                1980                
Glu Ala Pro Val Leu Phe Lys Lys Lys Leu Glu Pro Gln Thr Val Glu
1985                1990                1995                2000
Glu Arg Ser Ser Val Thr Leu Glu Val Glu Leu Thr Arg Pro Trp Pro
                2005                2010                2015    
Glu Leu Arg Trp Thr Arg Asn Ala Thr Ala Leu Ala Pro Gly Lys Asn
            2020                2025                2030        
Val Glu Ile His Ala Glu Gly Ala Arg His Arg Leu Val Leu His Asn
        2035                2040                2045            
Val Gly Phe Ala Asp Arg Gly Phe Phe Gly Cys Glu Thr Pro Asp Asp
    2050                2055                2060                
Lys Thr Gln Ala Lys Leu Thr Val Glu Met Arg Gln Val Arg Leu Val
2065                2070                2075                2080
Arg Gly Leu Gln Ala Val Glu Ala Arg Glu Gln Gly Thr Ala Thr Met
                2085                2090                2095    
Glu Val Gln Leu Ser His Ala Asp Val Asp Gly Ser Trp Thr Arg Asp
            2100                2105                2110        
Gly Leu Arg Phe Gln Gln Gly Pro Thr Cys His Leu Ala Val Arg Gly
        2115                2120                2125            
Pro Met His Thr Leu Thr Leu Ser Gly Leu Arg Pro Glu Asp Ser Gly
    2130                2135                2140                
Leu Met Val Phe Lys Ala Glu Gly Val His Thr Ser Ala Arg Leu Val
2145                2150                2155                2160
Val Thr Glu Leu Pro Val Ser Phe Ser Arg Pro Leu Gln Asp Val Val
                2165                2170                2175    
Thr Thr Glu Lys Glu Lys Val Thr Leu Glu Cys Glu Leu Ser Arg Pro
            2180                2185                2190        
Asn Val Asp Val Arg Trp Leu Lys Asp Gly Val Glu Leu Arg Ala Gly
        2195                2200                2205            
Lys Thr Met Ala Ile Ala Ala Gln Gly Ala Cys Arg Ser Leu Thr Ile
    2210                2215                2220                
Tyr Arg Cys Glu Phe Ala Asp Gln Gly Val Tyr Val Cys Asp Ala His
2225                2230                2235                2240
Asp Ala Gln Ser Ser Ala Ser Val Lys Val Gln Gly Arg Thr Tyr Thr
                2245                2250                2255    
Leu Ile Tyr Arg Arg Val Leu Ala Glu Asp Ala Gly Glu Ile Gln Phe
            2260                2265                2270        
Val Ala Glu Asn Ala Glu Ser Arg Ala Gln Leu Arg Val Lys Glu Leu
        2275                2280                2285            
Pro Val Thr Leu Val Arg Pro Leu Arg Asp Lys Ile Ala Met Glu Lys
    2290                2295                2300                
His Arg Gly Val Leu Glu Cys Gln Val Ser Arg Ala Ser Ala Gln Val
2305                2310                2315                2320
Arg Trp Phe Lys Gly Ser Gln Glu Leu Gln Pro Gly Pro Lys Tyr Glu
                2325                2330                2335    
Leu Val Ser Asp Gly Leu Tyr Arg Lys Leu Ile Ile Ser Asp Val His
            2340                2345                2350        
Ala Glu Asp Glu Asp Thr Tyr Thr Cys Asp Ala Gly Asp Val Lys Thr
        2355                2360                2365            
Ser Ala Gln Phe Phe Val Glu Glu Gln Ser Ile Thr Ile Val Arg Gly
    2370                2375                2380                
Leu Gln Asp Val Thr Val Met Glu Pro Ala Pro Ala Trp Phe Glu Cys
2385                2390                2395                2400
Glu Thr Ser Ile Pro Ser Val Arg Pro Pro Lys Trp Leu Leu Gly Lys
                2405                2410                2415    
Thr Val Leu Gln Ala Gly Gly Asn Val Gly Leu Glu Gln Glu Gly Thr
            2420                2425                2430        
Val His Arg Leu Met Leu Arg Arg Thr Cys Ser Thr Met Thr Gly Pro
        2435                2440                2445            
Val His Phe Thr Val Gly Lys Ser Arg Ser Ser Ala Arg Leu Val Val
    2450                2455                2460                
Ser Asp Ile Pro Val Val Leu Thr Arg Pro Leu Glu Pro Lys Thr Gly
2465                2470                2475                2480
Arg Glu Leu Gln Ser Val Val Leu Ser Cys Asp Phe Arg Pro Ala Pro
                2485                2490                2495    
Lys Ala Val Gln Trp Tyr Lys Asp Asp Thr Pro Leu Ser Pro Ser Glu
            2500                2505                2510        
Lys Phe Lys Met Ser Leu Glu Gly Gln Met Ala Glu Leu Arg Ile Leu
        2515                2520                2525            
Arg Leu Met Pro Ala Asp Ala Gly Val Tyr Arg Cys Gln Ala Gly Ser
    2530                2535                2540                
Ala His Ser Ser Thr Glu Val Thr Val Glu Ala Arg Glu Val Thr Val
2545                2550                2555                2560
Thr Gly Pro Leu Gln Asp Ala Glu Ala Thr Glu Glu Gly Trp Ala Ser
                2565                2570                2575    
Phe Ser Cys Glu Leu Ser His Glu Asp Glu Glu Val Glu Trp Ser Leu
            2580                2585                2590        
Asn Gly Met Pro Leu Tyr Asn Asp Ser Phe His Glu Ile Ser His Lys
        2595                2600                2605            
Gly Arg Arg His Thr Leu Val Leu Lys Ser Ile Gln Arg Ala Asp Ala
    2610                2615                2620                
Gly Ile Val Arg Ala Ser Ser Leu Lys Val Ser Thr Ser Ala Arg Leu
2625                2630                2635                2640
Glu Val Arg Val Lys Pro Val Val Phe Leu Lys Ala Leu Asp Asp Leu
                2645                2650                2655    
Ser Ala Glu Glu Arg Gly Thr Leu Ala Leu Gln Cys Glu Val Ser Asp
            2660                2665                2670        
Pro Glu Ala His Val Val Trp Arg Lys Asp Gly Val Gln Leu Gly Pro
        2675                2680                2685            
Ser Asp Lys Tyr Asp Phe Leu His Thr Ala Gly Thr Arg Gly Leu Val
    2690                2695                2700                
Val His Asp Val Ser Pro Glu Asp Ala Gly Leu Tyr Thr Cys His Val
2705                2710                2715                2720
Gly Ser Glu Glu Thr Arg Ala Arg Val Arg Val His Asp Leu His Val
                2725                2730                2735    
Gly Ile Thr Lys Arg Leu Lys Thr Met Glu Val Leu Glu Gly Glu Ser
            2740                2745                2750        
Cys Ser Phe Glu Cys Val Leu Ser His Glu Ser Ala Ser Asp Pro Ala
        2755                2760                2765            
Met Trp Thr Val Gly Gly Lys Thr Val Gly Ser Ser Ser Arg Phe Gln
    2770                2775                2780                
Ala Thr Arg Gln Gly Arg Lys Tyr Ile Leu Val Val Arg Glu Ala Ala
2785                2790                2795                2800
Pro Ser Asp Ala Gly Glu Val Val Phe Ser Val Arg Gly Leu Thr Ser
                2805                2810                2815    
Lys Ala Ser Leu Ile Val Arg Glu Arg Pro Ala Ala Ile Ile Lys Pro
            2820                2825                2830        
Leu Glu Asp Gln Trp Val Ala Pro Gly Glu Asp Val Glu Leu Arg Cys
        2835                2840                2845            
Glu Leu Ser Arg Ala Gly Thr Pro Val His Trp Leu Lys Asp Arg Lys
    2850                2855                2860                
Ala Ile Arg Lys Ser Gln Lys Tyr Asp Val Val Cys Glu Gly Thr Met
2865                2870                2875                2880
Ala Met Leu Val Ile Arg Gly Ala Ser Leu Lys Asp Ala Gly Glu Tyr
                2885                2890                2895    
Thr Cys Glu Val Glu Ala Ser Lys Ser Thr Ala Ser Leu His Val Glu
            2900                2905                2910        
Glu Lys Ala Asn Cys Phe Thr Glu Glu Leu Thr Asn Leu Gln Val Glu
        2915                2920                2925            
Glu Lys Gly Thr Ala Val Phe Thr Cys Lys Thr Glu His Pro Ala Ala
    2930                2935                2940                
Thr Val Thr Trp Arg Lys Gly Leu Leu Glu Leu Arg Ala Ser Gly Lys
2945                2950                2955                2960
His Gln Pro Ser Gln Glu Gly Leu Thr Leu Arg Leu Thr Ile Ser Ala
                2965                2970                2975    
Leu Glu Lys Ala Asp Ser Asp Thr Tyr Thr Cys Asp Ile Gly Gln Ala
            2980                2985                2990        
Gln Ser Arg Ala Gln Leu Leu Val Gln Gly Arg Arg Val His Ile Ile
        2995                3000                3005            
Glu Asp Leu Glu Asp Val Asp Val Gln Glu Gly Ser Ser Ala Thr Phe
    3010                3015                3020                
Arg Cys Arg Ile Ser Pro Ala Asn Tyr Glu Pro Val His Trp Phe Leu
3025                3030                3035                3040
Asp Lys Thr Pro Leu His Ala Asn Glu Leu Asn Glu Ile Asp Ala Gln
                3045                3050                3055    
Pro Gly Gly Tyr His Val Leu Thr Leu Arg Gln Leu Ala Leu Lys Asp
            3060                3065                3070        
Ser Gly Thr Ile Tyr Phe Glu Ala Gly Asp Gln Arg Ala Ser Ala Ala
        3075                3080                3085            
Leu Arg Val Thr Glu Lys Pro Ser Val Phe Ser Arg Glu Leu Thr Asp
    3090                3095                3100                
Ala Thr Ile Thr Glu Gly Glu Asp Leu Thr Leu Val Cys Glu Thr Ser
3105                3110                3115                3120
Thr Cys Asp Ile Pro Met Cys Trp Thr Lys Asp Gly Lys Thr Leu Arg
                3125                3130                3135    
Gly Ser Ala Arg Cys Gln Leu Ser His Glu Gly His Arg Ala Gln Leu
            3140                3145                3150        
Leu Ile Thr Gly Ala Thr Leu Gln Asp Ser Gly Arg Tyr Lys Cys Glu
        3155                3160                3165            
Ala Gly Gly Ala Cys Ser Ser Ser Ile Val Arg Val His Ala Arg Pro
    3170                3175                3180                
Val Arg Phe Gln Glu Ala Leu Lys Asp Leu Glu Val Leu Glu Gly Gly
3185                3190                3195                3200
Ala Ala Thr Leu Arg Cys Val Leu Ser Ser Val Ala Ala Pro Val Lys
                3205                3210                3215    
Trp Cys Tyr Gly Asn Asn Val Leu Arg Pro Gly Asp Lys Tyr Ser Leu
            3220                3225                3230        
Arg Gln Glu Gly Ala Met Leu Glu Leu Val Val Arg Asn Leu Arg Pro
        3235                3240                3245            
Gln Asp Ser Gly Arg Tyr Ser Cys Ser Phe Gly Asp Gln Thr Thr Ser
    3250                3255                3260                
Ala Thr Leu Thr Val Thr Ala Leu Pro Ala Gln Phe Ile Gly Lys Leu
3265                3270                3275                3280
Arg Asn Lys Glu Ala Thr Glu Gly Ala Thr Ala Thr Leu Arg Cys Glu
                3285                3290                3295    
Leu Ser Lys Thr Ala Pro Val Glu Trp Arg Lys Gly Ser Glu Thr Leu
            3300                3305                3310        
Arg Asp Gly Asp Arg Tyr Cys Leu Arg Gln Asp Gly Ala Met Cys Glu
        3315                3320                3325            
Leu Gln Ile Arg Gly Leu Ala Met Val Asp Ala Ala Glu Tyr Ser Cys
    3330                3335                3340                
Val Cys Gly Glu Glu Arg Thr Ser Ala Ser Leu Thr Ile Arg Pro Met
3345                3350                3355                3360
Pro Ala His Phe Ile Gly Arg Leu Arg His Gln Glu Ser Ile Glu Gly
                3365                3370                3375    
Ala Thr Ala Thr Leu Arg Cys Glu Leu Ser Lys Ala Ala Pro Val Glu
            3380                3385                3390        
Trp Arg Lys Gly Arg Glu Ser Leu Arg Asp Gly Asp Arg His Ser Leu
        3395                3400                3405            
Arg Gln Asp Gly Ala Val Cys Glu Leu Gln Ile Cys Gly Leu Ala Val
    3410                3415                3420                
Ala Asp Ala Gly Glu Tyr Ser Cys Val Cys Gly Glu Glu Arg Thr Ser
3425                3430                3435                3440
Ala Thr Leu Thr Val Lys Ala Leu Pro Ala Lys Phe Thr Glu Gly Leu
                3445                3450                3455    
Arg Asn Glu Glu Ala Val Glu Gly Ala Thr Ala Met Leu Trp Cys Glu
            3460                3465                3470        
Leu Ser Lys Val Ala Pro Val Glu Trp Arg Lys Gly Pro Glu Asn Leu
        3475                3480                3485            
Arg Asp Gly Asp Arg Tyr Ile Leu Arg Gln Glu Gly Thr Arg Cys Glu
    3490                3495                3500                
Leu Gln Ile Cys Gly Leu Ala Met Ala Asp Ala Gly Glu Tyr Leu Cys
3505                3510                3515                3520
Val Cys Gly Gln Glu Arg Thr Ser Ala Thr Leu Thr Ile Arg Ala Leu
                3525                3530                3535    
Pro Ala Arg Phe Ile Glu Asp Val Lys Asn Gln Glu Ala Arg Glu Gly
            3540                3545                3550        
Ala Thr Ala Val Leu Gln Cys Glu Leu Asn Ser Ala Ala Pro Val Glu
        3555                3560                3565            
Trp Arg Lys Gly Ser Glu Thr Leu Arg Asp Gly Asp Arg Tyr Ser Leu
    3570                3575                3580                
Arg Gln Asp Gly Thr Lys Cys Glu Leu Gln Ile Arg Gly Leu Ala Met
3585                3590                3595                3600
Ala Asp Thr Gly Glu Tyr Ser Cys Val Cys Gly Gln Glu Arg Thr Ser
                3605                3610                3615    
Ala Met Leu Thr Val Arg Ala Leu Pro Ile Lys Phe Thr Glu Gly Leu
            3620                3625                3630        
Arg Asn Glu Glu Ala Thr Glu Gly Ala Thr Ala Val Leu Arg Cys Glu
        3635                3640                3645            
Leu Ser Lys Met Ala Pro Val Glu Trp Trp Lys Gly His Glu Thr Leu
    3650                3655                3660                
Arg Asp Gly Asp Arg His Ser Leu Arg Gln Asp Gly Ala Arg Cys Glu
3665                3670                3675                3680
Leu Gln Ile Arg Gly Leu Val Ala Glu Asp Ala Gly Glu Tyr Leu Cys
                3685                3690                3695    
Met Cys Gly Lys Glu Arg Thr Ser Ala Met Leu Thr Val Arg Ala Met
            3700                3705                3710        
Pro Ser Lys Phe Ile Glu Gly Leu Arg Asn Glu Glu Ala Thr Glu Gly
        3715                3720                3725            
Asp Thr Ala Thr Leu Trp Cys Glu Leu Ser Lys Ala Ala Pro Val Glu
    3730                3735                3740                
Trp Arg Lys Gly His Glu Thr Leu Arg Asp Gly Asp Arg His Ser Leu
3745                3750                3755                3760
Arg Gln Asp Gly Ser Arg Cys Glu Leu Gln Ile Arg Gly Leu Ala Val
                3765                3770                3775    
Val Asp Ala Gly Glu Tyr Ser Cys Val Cys Gly Gln Glu Arg Thr Ser
            3780                3785                3790        
Ala Thr Leu Thr Val Arg Ala Leu Pro Ala Arg Phe Ile Glu Asp Val
        3795                3800                3805            
Lys Asn Gln Glu Ala Arg Glu Gly Ala Thr Ala Val Leu Gln Cys Glu
    3810                3815                3820                
Leu Ser Lys Ala Ala Pro Val Glu Trp Arg Lys Gly Ser Glu Thr Leu
3825                3830                3835                3840
Arg Gly Gly Asp Arg Tyr Ser Leu Arg Gln Asp Gly Thr Arg Cys Glu
                3845                3850                3855    
Leu Gln Ile His Gly Leu Ser Val Ala Asp Thr Gly Glu Tyr Ser Cys
            3860                3865                3870        
Val Cys Gly Gln Glu Arg Thr Ser Ala Thr Leu Thr Val Arg Ala Pro
        3875                3880                3885            
Gln Pro Val Phe Arg Glu Pro Leu Gln Ser Leu Gln Ala Glu Glu Gly
    3890                3895                3900                
Ser Thr Ala Thr Leu Gln Cys Glu Leu Ser Glu Pro Thr Ala Thr Val
3905                3910                3915                3920
Val Trp Ser Lys Gly Gly Leu Gln Leu Gln Ala Asn Gly Arg Arg Glu
                3925                3930                3935    
Pro Arg Leu Gln Gly Cys Thr Ala Glu Leu Val Leu Gln Asp Leu Gln
            3940                3945                3950        
Arg Glu Asp Thr Gly Glu Tyr Thr Cys Thr Cys Gly Ser Gln Ala Thr
        3955                3960                3965            
Ser Ala Thr Leu Thr Val Thr Ala Ala Pro Val Arg Phe Leu Arg Glu
    3970                3975                3980                
Leu Gln His Gln Glu Val Asp Glu Gly Gly Thr Ala His Leu Cys Cys
3985                3990                3995                4000
Glu Leu Ser Arg Ala Gly Ala Ser Val Glu Trp Arg Lys Gly Ser Leu
                4005                4010                4015    
Gln Leu Phe Pro Cys Ala Lys Tyr Gln Met Val Gln Asp Gly Ala Ala
            4020                4025                4030        
Ala Glu Leu Leu Val Arg Gly Val Glu Gln Glu Asp Ala Gly Asp Tyr
        4035                4040                4045            
Thr Cys Asp Thr Gly His Thr Gln Ser Met Ala Ser Leu Ser Val Arg
    4050                4055                4060                
Val Pro Arg Pro Lys Phe Lys Thr Arg Leu Gln Ser Leu Glu Gln Glu
4065                4070                4075                4080
Thr Gly Asp Ile Ala Arg Leu Cys Cys Gln Leu Ser Asp Ala Glu Ser
                4085                4090                4095    
Gly Ala Val Val Gln Trp Leu Lys Glu Gly Val Glu Leu His Ala Gly
            4100                4105                4110        
Pro Lys Tyr Glu Met Arg Ser Gln Gly Ala Thr Arg Glu Leu Leu Ile
        4115                4120                4125            
His Gln Leu Glu Ala Lys Asp Thr Gly Glu Tyr Ala Cys Val Thr Gly
    4130                4135                4140                
Gly Gln Lys Thr Ala Ala Ser Leu Arg Val Thr Glu Pro Glu Val Thr
4145                4150                4155                4160
Ile Val Arg Gly Leu Val Asp Ala Glu Val Thr Ala Asp Glu Asp Val
                4165                4170                4175    
Glu Phe Ser Cys Glu Val Ser Arg Ala Gly Ala Thr Gly Val Gln Trp
            4180                4185                4190        
Cys Leu Gln Gly Leu Pro Leu Gln Ser Asn Glu Val Thr Glu Val Ala
        4195                4200                4205            
Val Arg Asp Gly Arg Ile His Thr Leu Arg Leu Lys Gly Val Thr Pro
    4210                4215                4220                
Glu Asp Ala Gly Thr Val Ser Phe His Leu Gly Asn His Ala Ser Ser
4225                4230                4235                4240
Ala Gln Leu Thr Val Arg Ala Pro Glu Val Thr Ile Leu Glu Pro Leu
                4245                4250                4255    
Gln Asp Val Gln Leu Ser Glu Gly Gln Asp Ala Ser Phe Gln Cys Arg
            4260                4265                4270        
Leu Ser Arg Ala Ser Gly Gln Glu Ala Arg Trp Ala Leu Gly Gly Val
        4275                4280                4285            
Pro Leu Gln Ala Asn Glu Met Asn Asp Ile Thr Val Glu Gln Gly Thr
    4290                4295                4300                
Leu His Leu Leu Thr Leu His Lys Val Thr Leu Glu Asp Ala Gly Thr
4305                4310                4315                4320
Val Ser Phe His Val Gly Thr Cys Ser Ser Glu Ala Gln Leu Lys Val
                4325                4330                4335    
Thr Ala Lys Asn Thr Val Val Arg Gly Leu Glu Asn Val Glu Ala Leu
            4340                4345                4350        
Glu Gly Gly Glu Ala Leu Phe Glu Cys Gln Leu Ser Gln Pro Glu Val
        4355                4360                4365            
Ala Ala His Thr Trp Leu Leu Asp Asp Glu Pro Val Arg Thr Ser Glu
    4370                4375                4380                
Asn Ala Glu Val Val Phe Phe Glu Asn Gly Leu Arg His Leu Leu Leu
4385                4390                4395                4400
Leu Lys Asn Leu Arg Pro Gln Asp Ser Cys Arg Val Thr Phe Leu Ala
                4405                4410                4415    
Gly Asp Met Val Thr Ser Ala Phe Leu Thr Val Arg Gly Trp Arg Leu
            4420                4425                4430        
Glu Ile Leu Glu Pro Leu Lys Asn Ala Ala Val Arg Ala Gly Ala Gln
        4435                4440                4445            
Ala Arg Phe Thr Cys Thr Leu Ser Glu Ala Val Pro Val Gly Glu Ala
    4450                4455                4460                
Ser Trp Tyr Ile Asn Gly Ala Ala Val Gln Pro Asp Asp Ser Asp Trp
4465                4470                4475                4480
Thr Val Thr Ala Asp Gly Ser His Gln Ala Leu Leu Leu Arg Ser Ala
                4485                4490                4495    
Gln Pro His His Ala Gly Glu Val Thr Phe Ala Cys Arg Asp Ala Val
            4500                4505                4510        
Ala Ser Ala Arg Leu Thr Val Leu Gly Leu Pro Asp Pro Pro Glu Asp
        4515                4520                4525            
Ala Glu Val Val Ala His Ser Ser His Thr Val Thr Leu Ser Trp Ala
    4530                4535                4540                
Ala Pro Met Ser Asp Gly Gly Gly Gly Leu Cys Gly Tyr Arg Val Glu
4545                4550                4555                4560
Val Lys Glu Gly Ala Thr Gly Gln Trp Arg Leu Cys His Glu Leu Val
                4565                4570                4575    
Pro Gly Pro Glu Cys Val Val Asp Gly Leu Ala Pro Gly Glu Thr Tyr
            4580                4585                4590        
Arg Phe Arg Val Ala Ala Val Gly Pro Val Gly Ala Gly Glu Pro Val
        4595                4600                4605            
His Leu Pro Gln Thr Val Arg Leu Ala Glu Pro Pro Lys Pro Val Pro
    4610                4615                4620                
Pro Gln Pro Ser Ala Pro Glu Ser Arg Gln Val Ala Ala Gly Glu Asp
4625                4630                4635                4640
Val Ser Leu Glu Leu Glu Val Val Ala Glu Ala Gly Glu Val Ile Trp
                4645                4650                4655    
His Lys Gly Met Glu Arg Ile Gln Pro Gly Gly Arg Phe Glu Val Val
            4660                4665                4670        
Ser Gln Gly Arg Gln Gln Met Leu Val Ile Lys Gly Phe Thr Ala Glu
        4675                4680                4685            
Asp Gln Gly Glu Tyr His Cys Gly Leu Ala Gln Gly Ser Ile Cys Pro
    4690                4695                4700                
Ala Ala Ala Thr Phe Gln Val Ala Leu Ser Pro Ala Ser Val Asp Glu
4705                4710                4715                4720
Ala Pro Gln Pro Ser Leu Pro Pro Glu Ala Ala Gln Glu Gly Asp Leu
                4725                4730                4735    
His Leu Leu Trp Glu Ala Leu Ala Arg Lys Arg Arg Met Ser Arg Glu
            4740                4745                4750        
Pro Thr Leu Asp Ser Ile Ser Glu Leu Pro Glu Glu Asp Gly Arg Ser
        4755                4760                4765            
Gln Arg Leu Pro Gln Glu Ala Glu Glu Val Ala Pro Asp Leu Ser Glu
    4770                4775                4780                
Gly Tyr Ser Thr Ala Asp Glu Leu Ala Arg Thr Gly Asp Ala Asp Leu
4785                4790                4795                4800
Ser His Thr Ser Ser Asp Asp Glu Ser Arg Ala Gly Thr Pro Ser Leu
                4805                4810                4815    
Val Thr Tyr Leu Lys Lys Ala Gly Arg Pro Gly Thr Ser Pro Leu Ala
            4820                4825                4830        
Ser Lys Val Gly Ala Pro Ala Ala Pro Ser Val Lys Pro Gln Gln Gln
        4835                4840                4845            
Gln Glu Pro Leu Ala Ala Val Arg Pro Pro Leu Gly Asp Leu Ser Thr
    4850                4855                4860                
Lys Asp Leu Gly Asp Pro Ser Met Asp Lys Ala Ala Val Lys Ile Gln
4865                4870                4875                4880
Ala Ala Phe Lys Gly Tyr Lys Val Arg Lys Glu Met Lys Gln Gln Glu
                4885                4890                4895    
Gly Pro Met Phe Ser His Thr Phe Gly Asp Thr Glu Ala Gln Val Gly
            4900                4905                4910        
Asp Ala Leu Arg Leu Glu Cys Val Val Ala Ser Lys Ala Asp Val Arg
        4915                4920                4925            
Ala Arg Trp Leu Lys Asp Gly Val Glu Leu Thr Asp Gly Arg His His
    4930                4935                4940                
His Ile Asp Gln Leu Gly Asp Gly Thr Cys Ser Leu Leu Ile Ala Gly
4945                4950                4955                4960
Leu Asp Arg Ala Asp Ala Gly Cys Tyr Thr Cys Gln Val Ser Asn Lys
                4965                4970                4975    
Phe Gly Gln Val Thr His Ser Ala Cys Val Val Val Ser Gly Ser Glu
            4980                4985                4990        
Ser Glu Ala Glu Ser Ser Ser Gly Gly Glu Leu Asp Asp Ala Phe Arg
        4995                5000                5005            
Arg Ala Ala Arg Arg Leu His Arg Leu Phe Arg Thr Lys Ser Pro Ala
    5010                5015                5020                
Glu Val Ser Asp Glu Glu Leu Phe Leu Ser Ala Asp Glu Gly Pro Ala
5025                5030                5035                5040
Glu Pro Glu Glu Pro Ala Asp Trp Gln Thr Tyr Arg Glu Asp Glu His
                5045                5050                5055    
Phe Ile Cys Ile Arg Phe Glu Ala Leu Thr Glu Ala Arg Gln Ala Val
            5060                5065                5070        
Thr Arg Phe Gln Glu Met Phe Ala Thr Leu Gly Ile Gly Val Glu Ile
        5075                5080                5085            
Lys Leu Val Glu Gln Gly Pro Arg Arg Val Glu Met Cys Ile Ser Lys
    5090                5095                5100                
Glu Thr Pro Ala Pro Val Val Pro Pro Glu Pro Leu Pro Ser Leu Leu
5105                5110                5115                5120
Thr Ser Asp Ala Ala Pro Val Phe Leu Thr Glu Leu Gln Asn Gln Glu
                5125                5130                5135    
Val Gln Asp Gly Tyr Pro Val Ser Phe Asp Cys Val Val Thr Gly Gln
            5140                5145                5150        
Pro Met Pro Ser Val Arg Trp Phe Lys Asp Gly Lys Leu Leu Glu Glu
        5155                5160                5165            
Asp Asp His Tyr Met Ile Asn Glu Asp Gln Gln Gly Gly His Gln Leu
    5170                5175                5180                
Ile Ile Thr Ala Val Val Pro Ala Asp Met Gly Val Tyr Arg Cys Leu
5185                5190                5195                5200
Ala Glu Asn Ser Met Gly Val Ser Ser Thr Lys Ala Glu Leu Arg Val
                5205                5210                5215    
Asp Leu Thr Ser Thr Asp Tyr Asp Thr Ala Ala Asp Ala Thr Glu Ser
            5220                5225                5230        
Ser Ser Tyr Phe Ser Ala Gln Gly Tyr Leu Ser Ser Arg Glu Gln Glu
        5235                5240                5245            
Gly Thr Glu Ser Thr Thr Asp Glu Gly Gln Leu Pro Gln Val Val Glu
    5250                5255                5260                
Glu Leu Arg Asp Leu Gln Val Ala Pro Gly Thr Arg Leu Ala Lys Phe
5265                5270                5275                5280
Gln Leu Lys Val Lys Gly Tyr Pro Ala Pro Arg Leu Tyr Trp Phe Lys
                5285                5290                5295    
Asp Gly Gln Pro Leu Thr Ala Ser Ala His Ile Arg Met Thr Asp Lys
            5300                5305                5310        
Lys Ile Leu His Thr Leu Glu Ile Ile Ser Val Thr Arg Glu Asp Ser
        5315                5320                5325            
Gly Gln Tyr Ala Ala Tyr Ile Ser Asn Ala Met Gly Ala Ala Tyr Ser
    5330                5335                5340                
Ser Ala Arg Leu Leu Val Arg Gly Pro Asp Glu Pro Glu Glu Lys Pro
5345                5350                5355                5360
Ala Ser Asp Val His Glu Gln Leu Val Pro Pro Arg Met Leu Glu Arg
                5365                5370                5375    
Phe Thr Pro Lys Lys Val Lys Lys Gly Ser Ser Ile Thr Phe Ser Val
            5380                5385                5390        
Lys Val Glu Gly Arg Pro Val Pro Thr Val His Trp Leu Arg Glu Glu
        5395                5400                5405            
Ala Glu Arg Gly Val Leu Trp Ile Gly Pro Asp Thr Pro Gly Tyr Thr
    5410                5415                5420                
Val Ala Ser Ser Ala Gln Gln His Ser Leu Val Leu Leu Asp Val Gly
5425                5430                5435                5440
Arg Gln His Gln Gly Thr Tyr Thr Cys Ile Ala Ser Asn Ala Ala Gly
                5445                5450                5455    
Gln Ala Leu Cys Ser Ala Ser Leu His Val Ser Gly Leu Pro Lys Val
            5460                5465                5470        
Glu Glu Gln Glu Lys Val Lys Glu Ala Leu Ile Ser Thr Phe Leu Gln
        5475                5480                5485            
Gly Thr Thr Gln Ala Ile Ser Ala Gln Gly Phe Gln Thr Ala Ser Phe
    5490                5495                5500                
Ala Asp Leu Gly Gly Gln Arg Lys Glu Glu Pro Leu Ala Ala Lys Glu
5505                5510                5515                5520
Ala Leu Gly His Leu Ser Leu Ala Glu Val Gly Thr Glu Glu Phe Leu
                5525                5530                5535    
Gln Lys Leu Thr Ser Gln Ile Thr Glu Met Val Ser Ala Lys Ile Thr
            5540                5545                5550        
Gln Ala Lys Leu Gln Val Pro Gly Gly Asp Ser Asp Glu Asp Ser Lys
        5555                5560                5565            
Thr Pro Ser Ala Ser Pro Arg His Gly Arg Ser Arg Pro Ser Ser Ser
    5570                5575                5580                
Ile Gln Glu Ser Ser Ser Glu Ser Glu Asp Gly Asp Ala Arg Gly Glu
5585                5590                5595                5600
Ile Phe Asp Ile Tyr Val Val Thr Ala Asp Tyr Leu Pro Leu Gly Ala
                5605                5610                5615    
Glu Gln Asp Ala Ile Thr Leu Arg Glu Gly Gln Tyr Val Glu Val Leu
            5620                5625                5630        
Asp Ala Ala His Pro Leu Arg Trp Leu Val Arg Thr Lys Pro Thr Lys
        5635                5640                5645            
Ser Ser Pro Ser Arg Gln Gly Trp Val Ser Pro Ala Tyr Leu Asp Arg
    5650                5655                5660                
Arg Leu Lys Leu Ser Pro Glu Trp Gly Ala Ala Glu Ala Pro Glu Phe
5665                5670                5675                5680
Pro Gly Glu Ala Val Ser Glu Asp Glu Tyr Lys Ala Arg Leu Ser Ser
                5685                5690                5695    
Val Ile Gln Glu Leu Leu Ser Ser Glu Gln Ala Phe Val Glu Glu Leu
            5700                5705                5710        
Gln Phe Leu Gln Ser His His Leu Gln His Leu Glu Arg Cys Pro His
        5715                5720                5725            
Val Pro Ile Ala Val Ala Gly Gln Lys Ala Val Ile Phe Arg Asn Val
    5730                5735                5740                
Arg Asp Ile Gly Arg Phe His Ser Ser Phe Leu Gln Glu Leu Gln Gln
5745                5750                5755                5760
Cys Asp Thr Asp Asp Asp Val Ala Met Cys Phe Ile Lys Asn Gln Ala
                5765                5770                5775    
Ala Phe Glu Gln Tyr Leu Glu Phe Leu Val Gly Arg Val Gln Ala Glu
            5780                5785                5790        
Ser Val Val Val Ser Thr Ala Ile Gln Glu Phe Tyr Lys Lys Tyr Ala
        5795                5800                5805            
Glu Glu Ala Leu Leu Ala Gly Asp Pro Ser Gln Pro Pro Pro Pro Pro
    5810                5815                5820                
Leu Gln His Tyr Leu Glu Gln Pro Val Glu Arg Val Gln Arg Tyr Gln
5825                5830                5835                5840
Ala Leu Leu Lys Glu Leu Ile Arg Asn Lys Ala Arg Asn Arg Gln Asn
                5845                5850                5855    
Cys Ala Leu Leu Glu Gln Ala Tyr Ala Val Val Ser Ala Leu Pro Gln
            5860                5865                5870        
Arg Ala Glu Asn Lys Leu His Val Ser Leu Met Glu Asn Tyr Pro Gly
        5875                5880                5885            
Thr Leu Gln Ala Leu Gly Glu Pro Ile Arg Gln Gly His Phe Ile Val
    5890                5895                5900                
Trp Glu Gly Ala Pro Gly Ala Arg Met Pro Trp Lys Gly His Asn Arg
5905                5910                5915                5920
His Val Phe Leu Phe Arg Asn His Leu Val Ile Cys Lys Pro Arg Arg
                5925                5930                5935    
Asp Ser Arg Thr Asp Thr Val Ser Tyr Val Phe Arg Asn Met Met Lys
            5940                5945                5950        
Leu Ser Ser Ile Asp Leu Asn Asp Gln Val Glu Gly Asp Asp Arg Ala
        5955                5960                5965            
Phe Glu Val Trp Gln Glu Arg Glu Asp Ser Val Arg Lys Tyr Leu Leu
    5970                5975                5980                
Gln Ala Arg Thr Ala Ile Ile Lys Ser Ser Trp Val Lys Glu Ile Cys
5985                5990                5995                6000
Gly Ile Gln Gln Arg Leu Ala Leu Pro Val Trp Arg Pro Pro Asp Phe
                6005                6010                6015    
Glu Glu Glu Leu Ala Asp Cys Thr Ala Glu Leu Gly Glu Thr Val Lys
            6020                6025                6030        
Leu Ala Cys Arg Val Thr Gly Thr Pro Lys Pro Val Ile Ser Trp Tyr
        6035                6040                6045            
Lys Asp Gly Lys Ala Val Gln Val Asp Pro His His Ile Leu Ile Glu
    6050                6055                6060                
Asp Pro Asp Gly Ser Cys Ala Leu Ile Leu Asp Ser Leu Thr Gly Val
6065                6070                6075                6080
Asp Ser Gly Gln Tyr Met Cys Phe Ala Ala Ser Ala Ala Gly Asn Cys
                6085                6090                6095    
Ser Thr Leu Gly Lys Ile Leu Val Gln Val Pro Pro Arg Phe Val Asn
            6100                6105                6110        
Lys Val Leu Ala Ser Pro Phe Val Glu Gly Glu Asp Ala Gln Phe Thr
        6115                6120                6125            
Cys Thr Ile Glu Gly Ala Pro Tyr Pro Gln Ile Arg Trp Tyr Lys Asp
    6130                6135                6140                
Gly Ala Leu Leu Thr Thr Gly Asn Lys Phe Gln Thr Leu Ser Glu Pro
6145                6150                6155                6160
Arg Ser Gly Leu Leu Val Leu Val Ile Arg Ala Ala Ser Lys Glu Asp
                6165                6170                6175    
Leu Gly Leu Tyr Glu Cys Glu Leu Val Asn Arg Leu Gly Ser Ala Arg
            6180                6185                6190        
Ala Ser Ala Glu Leu Arg Ile Gln Ser Pro Met Leu Gln Ala Gln Glu
        6195                6200                6205            
Gln Cys His Arg Glu Gln Leu Val Ala Ala Val Glu Val Thr Glu Gln
    6210                6215                6220                
Glu Thr Lys Val Pro Lys Lys Thr Val Ile Ile Glu Glu Thr Ile Thr
6225                6230                6235                6240
Thr Val Val Lys Ser Pro Arg Gly Gln Arg Arg Ser Pro Ser Lys Ser
                6245                6250                6255    
Pro Ser Arg Ser Pro Ser Arg Cys Ser Ala Ser Pro Leu Arg Pro Gly
            6260                6265                6270        
Leu Leu Ala Pro Asp Leu Leu Tyr Leu Pro Gly Ala Gly Gln Pro Arg
        6275                6280                6285            
Arg Pro Glu Ala Glu Pro Gly Gln Lys Pro Val Val Pro Thr Leu Tyr
    6290                6295                6300                
Val Thr Glu Ala Glu Ala His Ser Pro Ala Leu Pro Gly Leu Ser Gly
6305                6310                6315                6320
Pro Gln Pro Lys Trp Val Glu Val Glu Glu Thr Ile Glu Val Arg Val
                6325                6330                6335    
Lys Lys Met Gly Pro Gln Gly Val Ser Pro Thr Thr Glu Val Pro Arg
            6340                6345                6350        
Ser Ser Ser Gly His Leu Phe Thr Leu Pro Gly Ala Thr Pro Gly Gly
        6355                6360                6365            
Asp Pro Asn Ser Asn Asn Ser Asn Asn Lys Leu Leu Ala Gln Glu Ala
    6370                6375                6380                
Trp Ala Gln Gly Thr Ala Met Val Gly Val Arg Glu Pro Leu Val Phe
6385                6390                6395                6400
Arg Val Asp Ala Arg Gly Ser Val Asp Trp Ala Ala Ser Gly Met Gly
                6405                6410                6415    
Ser Leu Glu Glu Glu Gly Thr Met Glu Glu Ala Gly Glu Glu Glu Gly
            6420                6425                6430        
Glu Asp Gly Asp Ala Phe Val Thr Glu Glu Ser Gln Asp Thr His Ser
        6435                6440                6445            
Leu Gly Asp Arg Asp Pro Lys Ile Leu Thr His Asn Gly Arg Met Leu
    6450                6455                6460                
Thr Leu Ala Asp Leu Glu Asp Tyr Val Pro Gly Glu Gly Glu Thr Phe
6465                6470                6475                6480
His Cys Gly Gly Pro Gly Pro Gly Ala Pro Asp Asp Pro Pro Cys Glu
                6485                6490                6495    
Val Ser Val Ile Gln Arg Glu Ile Gly Glu Pro Thr Val Gly Gln Pro
            6500                6505                6510        
Val Leu Leu Ser Val Gly His Ala Leu Gly Pro Arg Gly Pro Leu Gly
        6515                6520                6525            
Leu Phe Arg Pro Glu Pro Arg Gly Ala Ser Pro Pro Gly Pro Gln Val
    6530                6535                6540                
Arg Ser Leu Glu Gly Thr Ser Phe Leu Leu Arg Glu Ala Pro Ala Arg
6545                6550                6555                6560
Pro Val Gly Ser Ala Pro Trp Thr Gln Ser Phe Cys Thr Arg Ile Arg
                6565                6570                6575    
Arg Ser Ala Asp Ser Gly Gln Ser Ser Phe Thr Thr Glu Leu Ser Thr
            6580                6585                6590        
Gln Thr Val Asn Phe Gly Thr Val Gly Glu Thr Val Thr Leu His Ile
        6595                6600                6605            
Cys Pro Asp Arg Asp Gly Asp Glu Ala Ala Gln Glu
    6610                6615                6620


<210> 2292
<211> 103
<212> PRT
<213> Homo sapiens

<400> 2292
Met Glu Arg Gln Gln Gln Gln Gln Gln Gln Leu Arg Asn Leu Arg Asp
 1               5                  10                  15      
Phe Leu Leu Val Tyr Asn Arg Met Thr Glu Leu Cys Phe Gln Arg Cys
            20                  25                  30          
Val Pro Ser Leu His His Arg Ala Leu Asp Ala Glu Glu Glu Ala Cys
        35                  40                  45              
Leu His Ser Cys Ala Gly Lys Leu Ile His Ser Asn His Arg Leu Met
    50                  55                  60                  
Ala Ala Tyr Val Gln Leu Met Pro Ala Leu Val Gln Arg Arg Ile Ala
65                  70                  75                  80  
Asp Tyr Glu Ala Ala Ser Ala Val Pro Ser Val Ala Ala Glu Gln Pro
                85                  90                  95      
Gly Val Ser Pro Ser Gly Ser
            100             


<210> 2293
<211> 447
<212> PRT
<213> Homo sapiens

<400> 2293
Leu Ser Asp Ala Arg Trp Ala Glu Leu Leu Pro Leu Leu Gln Gln Cys
 1               5                  10                  15      
Gln Val Val Arg Leu Asp Asp Cys Gly Leu Thr Glu Ala Arg Cys Lys
            20                  25                  30          
Asp Ile Ser Ser Ala Leu Arg Val Asn Pro Ala Leu Ala Glu Leu Asn
        35                  40                  45              
Leu Arg Ser Asn Glu Leu Gly Asp Val Gly Val His Cys Val Leu Gln
    50                  55                  60                  
Gly Leu Gln Thr Pro Ser Cys Lys Ile Gln Lys Leu Ser Leu Gln Asn
65                  70                  75                  80  
Cys Cys Leu Thr Gly Ala Gly Cys Gly Val Leu Ser Ser Thr Leu Arg
                85                  90                  95      
Thr Leu Pro Thr Leu Gln Glu Leu His Leu Ser Asp Asn Leu Leu Gly
            100                 105                 110         
Asp Ala Gly Leu Gln Leu Leu Cys Glu Gly Leu Leu Asp Pro Gln Cys
        115                 120                 125             
Arg Leu Glu Lys Leu Gln Leu Glu Tyr Cys Ser Leu Ser Ala Ala Ser
    130                 135                 140                 
Cys Glu Pro Leu Ala Ser Val Leu Arg Ala Lys Pro Asp Phe Lys Glu
145                 150                 155                 160 
Leu Thr Val Ser Asn Asn Asp Ile Asn Glu Ala Gly Val Arg Val Leu
                165                 170                 175     
Cys Gln Gly Leu Lys Asp Ser Pro Cys Gln Leu Glu Ala Leu Lys Leu
            180                 185                 190         
Glu Ser Cys Gly Val Thr Ser Asp Asn Cys Arg Asp Leu Cys Gly Ile
        195                 200                 205             
Val Ala Ser Lys Ala Ser Leu Arg Glu Leu Ala Leu Gly Ser Asn Lys
    210                 215                 220                 
Leu Gly Asp Val Gly Met Ala Glu Leu Cys Pro Gly Leu Leu His Pro
225                 230                 235                 240 
Ser Ser Arg Leu Arg Thr Leu Trp Ile Trp Glu Cys Gly Ile Thr Ala
                245                 250                 255     
Lys Gly Cys Gly Asp Leu Cys Arg Val Leu Arg Ala Lys Glu Ser Leu
            260                 265                 270         
Lys Glu Leu Ser Leu Ala Gly Asn Glu Leu Gly Asp Glu Gly Ala Arg
        275                 280                 285             
Leu Leu Cys Glu Thr Leu Leu Glu Pro Gly Cys Gln Leu Glu Ser Leu
    290                 295                 300                 
Trp Val Lys Ser Cys Ser Phe Thr Ala Ala Cys Cys Ser His Phe Ser
305                 310                 315                 320 
Ser Val Leu Ala Gln Asn Arg Phe Leu Leu Glu Leu Gln Ile Ser Asn
                325                 330                 335     
Asn Arg Leu Glu Asp Ala Gly Val Arg Glu Leu Cys Gln Gly Leu Gly
            340                 345                 350         
Gln Pro Gly Ser Val Leu Arg Val Leu Trp Leu Ala Asp Cys Asp Val
        355                 360                 365             
Ser Asp Ser Ser Cys Ser Ser Leu Ala Ala Thr Leu Leu Ala Asn His
    370                 375                 380                 
Ser Leu Arg Glu Leu Asp Leu Ser Asn Asn Cys Leu Gly Asp Ala Gly
385                 390                 395                 400 
Ile Leu Gln Leu Val Glu Ser Val Arg Gln Pro Gly Cys Leu Leu Glu
                405                 410                 415     
Gln Leu Val Leu Tyr Asp Ile Tyr Trp Ser Glu Glu Met Glu Asp Arg
            420                 425                 430         
Leu Gln Ala Leu Glu Lys Asp Lys Pro Ser Leu Arg Val Ile Ser
        435                 440                 445         


<210> 2294
<211> 553
<212> PRT
<213> Homo sapiens

<400> 2294
Met Leu Ser Val Arg Val Ala Ala Ala Val Val Arg Ala Leu Pro Arg
 1               5                  10                  15      
Arg Ala Gly Leu Val Ser Arg Asn Ala Leu Gly Ser Ser Phe Ile Ala
            20                  25                  30          
Ala Arg Asn Phe His Ala Ser Asn Thr His Leu Gln Lys Thr Gly Thr
        35                  40                  45              
Ala Glu Met Ser Ser Ile Leu Glu Glu Arg Ile Leu Gly Ala Asp Thr
    50                  55                  60                  
Ser Val Asp Leu Glu Glu Thr Gly Arg Val Leu Ser Ile Gly Asp Gly
65                  70                  75                  80  
Ile Ala Arg Val His Gly Leu Arg Asn Val Gln Ala Glu Glu Met Val
                85                  90                  95      
Glu Phe Ser Ser Gly Leu Lys Gly Met Ser Leu Asn Leu Glu Pro Asp
            100                 105                 110         
Asn Val Gly Val Val Val Phe Gly Asn Asp Lys Leu Ile Lys Glu Gly
        115                 120                 125             
Asp Ile Val Lys Arg Thr Gly Ala Ile Val Asp Val Pro Val Gly Glu
    130                 135                 140                 
Glu Leu Leu Gly Arg Val Val Asp Ala Leu Gly Asn Ala Ile Asp Gly
145                 150                 155                 160 
Lys Gly Pro Ile Gly Ser Lys Thr Arg Arg Arg Val Gly Leu Lys Ala
                165                 170                 175     
Pro Gly Ile Ile Pro Arg Ile Ser Val Arg Glu Pro Met Gln Thr Gly
            180                 185                 190         
Ile Lys Ala Val Asp Ser Leu Val Pro Ile Gly Arg Gly Gln Arg Glu
        195                 200                 205             
Leu Ile Ile Gly Asp Arg Gln Thr Gly Lys Thr Ser Ile Ala Ile Asp
    210                 215                 220                 
Thr Ile Ile Asn Gln Lys Arg Phe Asn Asp Gly Ser Asp Glu Lys Lys
225                 230                 235                 240 
Lys Leu Tyr Cys Ile Tyr Val Ala Ile Gly Gln Lys Arg Ser Thr Val
                245                 250                 255     
Ala Gln Leu Val Lys Arg Leu Thr Asp Ala Asp Ala Met Lys Tyr Thr
            260                 265                 270         
Ile Val Val Ser Ala Thr Ala Ser Asp Ala Ala Pro Leu Gln Tyr Leu
        275                 280                 285             
Ala Pro Tyr Ser Gly Cys Ser Met Gly Glu Tyr Phe Arg Asp Asn Gly
    290                 295                 300                 
Lys His Ala Leu Ile Ile Tyr Asp Asp Leu Ser Lys Gln Ala Val Ala
305                 310                 315                 320 
Tyr Arg Gln Met Ser Leu Leu Leu Arg Arg Pro Pro Gly Arg Glu Ala
                325                 330                 335     
Tyr Pro Gly Asp Val Phe Tyr Leu His Ser Arg Leu Leu Glu Arg Ala
            340                 345                 350         
Ala Lys Met Asn Asp Ala Phe Gly Gly Gly Ser Leu Thr Ala Leu Pro
        355                 360                 365             
Val Ile Glu Thr Gln Ala Gly Asp Val Ser Ala Tyr Ile Pro Thr Asn
    370                 375                 380                 
Val Ile Ser Ile Thr Asp Gly Gln Ile Phe Leu Glu Thr Glu Leu Phe
385                 390                 395                 400 
Tyr Lys Gly Ile Arg Pro Ala Ile Asn Val Gly Leu Ser Val Ser Arg
                405                 410                 415     
Val Gly Ser Ala Ala Gln Thr Arg Ala Met Lys Gln Val Ala Gly Thr
            420                 425                 430         
Met Lys Leu Glu Leu Ala Gln Tyr Arg Glu Val Ala Ala Phe Ala Gln
        435                 440                 445             
Phe Gly Ser Asp Leu Asp Ala Ala Thr Gln Gln Leu Leu Ser Arg Gly
    450                 455                 460                 
Val Arg Leu Thr Glu Leu Leu Lys Gln Gly Gln Tyr Ser Pro Met Ala
465                 470                 475                 480 
Ile Glu Glu Gln Val Ala Val Ile Tyr Ala Gly Val Arg Gly Tyr Leu
                485                 490                 495     
Asp Lys Leu Glu Pro Ser Lys Ile Thr Lys Phe Glu Asn Asp Phe Leu
            500                 505                 510         
Ser His Val Val Ser Gln His Gln Ala Leu Leu Gly Thr Ile Arg Ala
        515                 520                 525             
Glu Gly Lys Ile Ser Glu Gln Ser Asp Ala Lys Leu Lys Glu Ile Val
    530                 535                 540                 
Thr Asn Phe Leu Ala Gly Phe Glu Ala
545                 550             


<210> 2295
<211> 1004
<212> PRT
<213> Homo sapiens

<400> 2295
Met Val Gln Leu Tyr Asn Leu His Pro Phe Gly Ser Gln Gln Val Val
 1               5                  10                  15      
Pro Cys Lys Leu Glu Pro Asp Arg Phe Cys Gly Gly Gly Arg Asp Ala
            20                  25                  30          
Leu Phe Val Ala Ala Gly Cys Lys Val Glu Ala Phe Ala Val Ala Gly
        35                  40                  45              
Gln Glu Leu Cys Gln Pro Arg Cys Ala Phe Ser Thr Leu Gly Arg Val
    50                  55                  60                  
Leu Arg Leu Ala Tyr Ser Glu Ala Gly Asp Tyr Leu Val Ala Ile Glu
65                  70                  75                  80  
Glu Lys Asn Lys Ala Thr Phe Leu Arg Ala Tyr Val Asn Trp Arg Asn
                85                  90                  95      
Lys Arg Thr Glu Asn Ser Arg Val Cys Ile Arg Met Ile Gly His Asn
            100                 105                 110         
Val Glu Gly Pro Phe Ser Lys Ala Phe Arg Asp Gln Met Tyr Ile Ile
        115                 120                 125             
Glu Met Pro Leu Ser Glu Ala Pro Leu Cys Ile Ser Cys Cys Pro Val
    130                 135                 140                 
Lys Gly Asp Leu Leu Val Gly Cys Thr Asn Lys Leu Val Leu Phe Ser
145                 150                 155                 160 
Leu Lys Tyr Gln Ile Ile Asn Glu Glu Phe Ser Leu Leu Asp Phe Glu
                165                 170                 175     
Arg Ser Leu Ile Ile His Ile Asp Asn Ile Thr Pro Val Glu Val Ser
            180                 185                 190         
Phe Cys Val Gly Tyr Val Ala Val Met Ser Asp Leu Glu Val Leu Ile
        195                 200                 205             
Val Lys Leu Glu Ser Gly Pro Lys Asn Gly Glu Arg Val His His His
    210                 215                 220                 
Pro His Lys Thr Asn Asn Arg Ile Arg Arg Thr Glu Glu Gly Ile Ser
225                 230                 235                 240 
Asn Glu Ile Ser Gln Leu Glu Ser Asp Asp Phe Val Ile Cys Gln Lys
                245                 250                 255     
Pro Leu Glu Leu Leu Gly Glu Lys Ser Glu Gln Ser Gly Leu Ser Val
            260                 265                 270         
Thr Leu Glu Ser Thr Gly Leu Ala Asp Glu Lys Arg Lys Tyr Ser His
        275                 280                 285             
Phe Gln His Leu Leu Tyr Arg Arg Phe Ala Pro Asp Ile Ser Ser Tyr
    290                 295                 300                 
Val Leu Ser Asp Asp Ile Lys Leu His Ser Leu Gln Leu Leu Pro Ile
305                 310                 315                 320 
Tyr Gln Thr Gly Ser Leu Thr Ser Asp Gly Lys Asn Leu Ser Gln Glu
                325                 330                 335     
Lys Glu Leu Leu Ser Leu Phe Cys Phe Phe Ser Leu Pro His Val Gly
            340                 345                 350         
Tyr Leu Tyr Met Val Val Lys Ser Val Glu Leu Met Ser Val Tyr Gln
        355                 360                 365             
Tyr Pro Glu Lys Ser Gln Gln Ala Val Leu Thr Pro Gln Phe Leu His
    370                 375                 380                 
Val Ile Thr Ser Asn Asn Leu Gln Cys Phe Thr Val Arg Cys Ser Ala
385                 390                 395                 400 
Ala Ala Ala Arg Glu Glu Asp Pro Tyr Met Asp Thr Thr Leu Lys Ala
                405                 410                 415     
Cys Pro Pro Val Ser Met Asp Val Cys Ala Leu Arg Ile Gln Leu Phe
            420                 425                 430         
Ile Gly Leu Lys Ala Ile Cys His Phe Lys Asn His Ile Ile Leu Leu
        435                 440                 445             
Thr Lys Ala Glu Pro Glu Ala Ile Pro Glu Arg Arg Gln Ser Pro Lys
    450                 455                 460                 
Arg Leu Leu Ser Arg Lys Asp Thr Ser Val Lys Ile Lys Ile Pro Pro
465                 470                 475                 480 
Val Ala Glu Ala Gly Trp Asn Leu Tyr Ile Val Asn Thr Ile Ser Pro
                485                 490                 495     
Val Gln Leu Tyr Lys Glu Met Val Asp Tyr Ser Asn Thr Tyr Lys Thr
            500                 505                 510         
Val Lys Thr Gln Ser Cys Ile His Leu Leu Ser Glu Ala His Leu Leu
        515                 520                 525             
Val Arg Ala Ala Leu Met Asp Ala Ser Gln Leu Glu Pro Gly Glu Lys
    530                 535                 540                 
Ala Glu Leu Leu Glu Ala Phe Lys Glu Ser Cys Gly His Leu Gly Asp
545                 550                 555                 560 
Cys Tyr Ser Arg Leu Asp Ser Gln His Ser His Leu Thr Leu Pro Tyr
                565                 570                 575     
Tyr Lys Met Ser Gly Leu Ser Met Ala Glu Val Leu Ala Arg Thr Asp
            580                 585                 590         
Trp Thr Val Glu Asp Gly Leu Gln Lys Tyr Glu Arg Gly Leu Ile Phe
        595                 600                 605             
Tyr Ile Asn His Ser Leu Tyr Glu Asn Leu Asp Glu Glu Leu Asn Glu
    610                 615                 620                 
Glu Leu Ala Ala Lys Val Val Gln Met Phe Tyr Val Ala Glu Pro Lys
625                 630                 635                 640 
Gln Val Pro His Ile Leu Cys Ser Pro Ser Met Lys Asn Ile Asn Pro
                645                 650                 655     
Leu Thr Ala Met Ser Tyr Leu Arg Lys Leu Asp Thr Ser Gly Phe Ser
            660                 665                 670         
Ser Ile Leu Val Thr Leu Thr Lys Ala Ala Val Ala Leu Lys Met Gly
        675                 680                 685             
Asp Leu Asp Met His Arg Asn Glu Met Lys Ser His Ser Glu Met Lys
    690                 695                 700                 
Leu Val Cys Gly Phe Ile Leu Glu Pro Arg Leu Leu Ile Gln Gln Arg
705                 710                 715                 720 
Lys Gly Gln Ile Val Pro Thr Glu Leu Ala Leu His Leu Lys Glu Thr
                725                 730                 735     
Gln Pro Gly Leu Leu Val Ala Ser Val Leu Gly Leu Gln Lys Asn Asn
            740                 745                 750         
Lys Ile Gly Ile Glu Glu Ala Asp Ser Phe Phe Lys Val Leu Cys Ala
        755                 760                 765             
Lys Asp Glu Asp Thr Ile Pro Gln Leu Leu Val Asp Phe Trp Glu Ala
    770                 775                 780                 
Gln Leu Val Ala Cys Leu Pro Asp Val Val Leu Gln Glu Leu Phe Phe
785                 790                 795                 800 
Lys Leu Thr Ser Gln Tyr Ile Trp Arg Leu Ser Lys Arg Gln Pro Pro
                805                 810                 815     
Asp Thr Thr Pro Leu Arg Thr Ser Glu Asp Leu Ile Asn Ala Cys Ser
            820                 825                 830         
His Tyr Gly Leu Ile Tyr Pro Trp Val His Val Val Ile Ser Ser Asp
        835                 840                 845             
Ser Leu Ala Asp Lys Asn Tyr Thr Glu Asp Leu Ser Lys Leu Gln Ser
    850                 855                 860                 
Leu Ile Cys Gly Pro Ser Phe Asp Ile Ala Ser Ile Ile Pro Phe Leu
865                 870                 875                 880 
Glu Pro Leu Ser Glu Asp Thr Ile Ala Gly Leu Ser Val His Val Leu
                885                 890                 895     
Cys Arg Thr Arg Leu Lys Glu Tyr Glu Gln Cys Ile Asp Ile Leu Leu
            900                 905                 910         
Glu Arg Cys Pro Glu Ala Val Ile Pro Tyr Ala Asn His Glu Leu Lys
        915                 920                 925             
Glu Glu Asn Arg Thr Leu Trp Trp Lys Lys Leu Leu Pro Glu Leu Cys
    930                 935                 940                 
Gln Arg Ile Lys Cys Gly Gly Glu Lys Tyr Gln Leu Tyr Leu Ser Ser
945                 950                 955                 960 
Leu Lys Glu Thr Leu Ser Ile Val Ala Val Glu Leu Glu Leu Lys Asp
                965                 970                 975     
Phe Met Asn Val Leu Pro Glu Asp Gly Thr Ala Thr Phe Phe Leu Pro
            980                 985                 990         
Tyr Leu Leu Tyr Cys Ser Arg Lys Lys Pro Leu Thr
        995                 1000                


<210> 2296
<211> 428
<212> PRT
<213> Homo sapiens

<400> 2296
Met Ala Thr Ser Trp Gly Thr Val Phe Phe Met Leu Val Val Ser Cys
 1               5                  10                  15      
Val Cys Ser Ala Val Ser His Arg Asn Gln Gln Thr Trp Phe Glu Gly
            20                  25                  30          
Ile Phe Leu Ser Ser Met Cys Pro Ile Asn Val Ser Ala Ser Thr Leu
        35                  40                  45              
Tyr Gly Ile Met Phe Asp Ala Gly Ser Thr Gly Thr Arg Ile His Val
    50                  55                  60                  
Tyr Thr Phe Val Gln Lys Ala Ala Gly Gln Leu Pro Ile Leu Glu Gly
65                  70                  75                  80  
Glu Val Phe Asp Ser Val Lys Pro Gly Leu Ser Ala Phe Val Asp Gln
                85                  90                  95      
Pro Lys Gln Gly Ala Glu Thr Val Gln Gly Leu Leu Glu Val Ala Lys
            100                 105                 110         
Asp Ser Ile Pro Arg Ser His Trp Lys Lys Thr Pro Val Val Leu Lys
        115                 120                 125             
Ala Thr Ala Gly Leu Arg Leu Leu Pro Glu His Lys Ala Lys Ala Leu
    130                 135                 140                 
Leu Phe Glu Val Lys Glu Ile Phe Arg Lys Ser Pro Phe Leu Val Pro
145                 150                 155                 160 
Lys Gly Ser Val Ser Ile Met Asp Gly Ser Asp Glu Gly Ile Leu Ala
                165                 170                 175     
Trp Val Thr Val Asn Phe Leu Thr Gly Gln Leu His Gly His Arg Gln
            180                 185                 190         
Glu Thr Val Gly Thr Leu Asp Leu Gly Gly Ala Ser Thr Gln Ile Thr
        195                 200                 205             
Phe Leu Pro Gln Phe Glu Lys Thr Leu Glu Gln Thr Pro Arg Gly Tyr
    210                 215                 220                 
Leu Thr Ser Phe Glu Met Phe Asn Ser Thr Tyr Lys Leu Tyr Thr His
225                 230                 235                 240 
Ser Tyr Leu Gly Phe Gly Leu Lys Ala Ala Arg Leu Ala Thr Leu Gly
                245                 250                 255     
Ala Leu Glu Thr Glu Gly Thr Asp Gly His Thr Phe Arg Ser Ala Cys
            260                 265                 270         
Leu Pro Arg Trp Leu Glu Ala Glu Trp Ile Phe Gly Gly Val Lys Tyr
        275                 280                 285             
Gln Tyr Gly Gly Asn Gln Glu Gly Glu Val Gly Phe Glu Pro Cys Tyr
    290                 295                 300                 
Ala Glu Val Leu Arg Val Val Arg Gly Lys Leu His Gln Pro Glu Glu
305                 310                 315                 320 
Val Gln Arg Gly Ser Phe Tyr Ala Phe Ser Tyr Tyr Tyr Asp Arg Ala
                325                 330                 335     
Val Asp Thr Asp Met Ile Asp Tyr Glu Lys Gly Gly Ile Leu Lys Val
            340                 345                 350         
Glu Asp Phe Glu Arg Lys Ala Arg Glu Val Cys Asp Asn Leu Glu Asn
        355                 360                 365             
Phe Thr Ser Gly Ser Pro Phe Leu Cys Met Asp Leu Ser Tyr Ile Thr
    370                 375                 380                 
Ala Leu Leu Lys Asp Gly Phe Gly Phe Ala Asp Ser Thr Val Leu Gln
385                 390                 395                 400 
Leu Thr Lys Lys Val Asn Asn Ile Glu Thr Gly Trp Ala Leu Gly Ala
                405                 410                 415     
Thr Phe His Leu Leu Gln Ser Leu Gly Ile Ser His
            420                 425             


<210> 2297
<211> 485
<212> PRT
<213> Homo sapiens

<400> 2297
Met Arg Lys Arg Ala Pro Gln Ser Glu Met Ala Pro Ala Gly Val Ser
 1               5                  10                  15      
Leu Arg Ala Thr Ile Leu Cys Leu Leu Ala Trp Ala Gly Leu Ala Ala
            20                  25                  30          
Gly Asp Arg Val Tyr Ile His Pro Phe His Leu Val Ile His Asn Glu
        35                  40                  45              
Ser Thr Cys Glu Gln Leu Ala Lys Ala Asn Ala Gly Lys Pro Lys Asp
    50                  55                  60                  
Pro Thr Phe Ile Pro Ala Pro Ile Gln Ala Lys Thr Ser Pro Val Asp
65                  70                  75                  80  
Glu Lys Ala Leu Gln Asp Gln Leu Val Leu Val Ala Ala Lys Leu Asp
                85                  90                  95      
Thr Glu Asp Lys Leu Arg Ala Ala Met Val Gly Met Leu Ala Asn Phe
            100                 105                 110         
Leu Gly Phe Arg Ile Tyr Gly Met His Ser Glu Leu Trp Gly Val Val
        115                 120                 125             
His Gly Ala Thr Val Leu Ser Pro Thr Ala Val Phe Gly Thr Leu Ala
    130                 135                 140                 
Ser Leu Tyr Leu Gly Ala Leu Asp His Thr Ala Asp Arg Leu Gln Ala
145                 150                 155                 160 
Ile Leu Gly Val Pro Trp Lys Asp Lys Asn Cys Thr Ser Arg Leu Asp
                165                 170                 175     
Ala His Lys Val Leu Ser Ala Leu Gln Ala Val Gln Gly Leu Leu Val
            180                 185                 190         
Ala Gln Gly Arg Ala Asp Ser Gln Ala Gln Leu Leu Leu Ser Thr Val
        195                 200                 205             
Val Gly Val Phe Thr Ala Pro Gly Leu His Leu Lys Gln Pro Phe Val
    210                 215                 220                 
Gln Gly Leu Ala Leu Tyr Thr Pro Val Val Leu Pro Arg Ser Leu Asp
225                 230                 235                 240 
Phe Thr Glu Leu Asp Val Ala Ala Glu Lys Ile Asp Arg Phe Met Gln
                245                 250                 255     
Ala Val Thr Gly Trp Lys Thr Gly Cys Ser Leu Thr Gly Ala Ser Val
            260                 265                 270         
Asp Ser Thr Leu Ala Phe Asn Thr Tyr Val His Phe Gln Gly Lys Met
        275                 280                 285             
Lys Gly Phe Ser Leu Leu Ala Glu Pro Gln Glu Phe Trp Val Asp Asn
    290                 295                 300                 
Ser Thr Ser Val Ser Val Pro Met Leu Ser Gly Met Gly Thr Phe Gln
305                 310                 315                 320 
His Trp Ser Asp Ile Gln Asp Asn Phe Ser Val Thr Gln Val Ser Phe
                325                 330                 335     
Thr Glu Ser Ala Cys Leu Leu Leu Ile Gln Pro His Tyr Ala Ser Asp
            340                 345                 350         
Leu Asp Lys Val Glu Gly Leu Thr Phe Gln Gln Asn Ser Leu Asn Trp
        355                 360                 365             
Met Lys Lys Leu Ser Pro Arg Thr Ile His Leu Thr Met Pro Gln Leu
    370                 375                 380                 
Val Leu Gln Gly Ser Tyr Asp Leu Gln Asp Leu Leu Ala Gln Ala Glu
385                 390                 395                 400 
Leu Pro Ala Ile Leu His Thr Glu Leu Asn Leu Gln Lys Leu Ser Asn
                405                 410                 415     
Asp Arg Ile Arg Val Gly Glu Val Leu Asn Ser Ile Phe Phe Glu Leu
            420                 425                 430         
Glu Ala Asp Glu Arg Glu Pro Thr Glu Ser Thr Gln Gln Leu Asn Lys
        435                 440                 445             
Pro Glu Val Leu Glu Val Thr Leu Asn Arg Pro Phe Leu Phe Ala Val
    450                 455                 460                 
Tyr Asp Gln Ser Ala Thr Ala Leu His Phe Leu Gly Arg Val Ala Asn
465                 470                 475                 480 
Pro Leu Ser Thr Ala
                485 


<210> 2298
<211> 861
<212> PRT
<213> Homo sapiens

<400> 2298
Met Ala His Tyr Pro Thr Arg Leu Thr Thr Arg Lys Thr Tyr Ser Trp
 1               5                  10                  15      
Val Gly Arg Pro Leu Leu Asp Arg Lys Leu His Tyr Gln Thr Tyr Arg
            20                  25                  30          
Glu Met Cys Val Lys Thr Glu Gly Cys Ser Thr Glu Ile His Ile Gln
        35                  40                  45              
Ile Gly Gln Phe Val Leu Ile Glu Gly Asp Asp Asp Glu Asn Pro Tyr
    50                  55                  60                  
Val Ala Lys Leu Leu Glu Leu Phe Glu Asp Asp Ser Asp Pro Pro Pro
65                  70                  75                  80  
Lys Lys Arg Ala Arg Val Gln Trp Phe Val Arg Phe Cys Glu Val Pro
                85                  90                  95      
Ala Cys Lys Arg His Leu Leu Gly Arg Lys Pro Gly Ala Gln Glu Ile
            100                 105                 110         
Phe Trp Tyr Asp Tyr Pro Ala Cys Asp Ser Asn Ile Asn Ala Glu Thr
        115                 120                 125             
Ile Ile Gly Leu Val Arg Val Ile Pro Leu Ala Pro Lys Asp Val Val
    130                 135                 140                 
Pro Thr Asn Leu Lys Asn Glu Lys Thr Leu Phe Val Lys Leu Ser Trp
145                 150                 155                 160 
Asn Glu Lys Lys Phe Arg Pro Leu Ser Ser Glu Leu Phe Ala Glu Leu
                165                 170                 175     
Asn Lys Pro Gln Glu Ser Ala Ala Lys Cys Gln Lys Pro Val Arg Ala
            180                 185                 190         
Lys Ser Lys Ser Ala Glu Ser Pro Ser Trp Thr Pro Ala Glu His Val
        195                 200                 205             
Ala Lys Arg Ile Glu Ser Arg His Ser Ala Ser Lys Ser Arg Gln Thr
    210                 215                 220                 
Pro Thr His Pro Leu Thr Pro Arg Ala Arg Lys Arg Leu Glu Leu Gly
225                 230                 235                 240 
Asn Leu Gly Asn Pro Gln Met Ser Gln Gln Thr Ser Cys Ala Ser Leu
                245                 250                 255     
Asp Ser Pro Gly Arg Ile Lys Arg Lys Val Ala Phe Ser Glu Ile Thr
            260                 265                 270         
Ser Pro Ser Lys Arg Ser Gln Pro Asp Lys Leu Gln Thr Leu Ser Pro
        275                 280                 285             
Ala Leu Lys Ala Pro Glu Lys Thr Arg Glu Thr Gly Leu Ser Tyr Thr
    290                 295                 300                 
Glu Asp Asp Lys Lys Ala Ser Pro Glu His Arg Ile Ile Leu Arg Thr
305                 310                 315                 320 
Arg Ile Ala Ala Ser Lys Thr Ile Asp Ile Arg Glu Glu Arg Thr Leu
                325                 330                 335     
Thr Pro Ile Ser Gly Gly Gln Arg Ser Ser Val Val Pro Ser Val Ile
            340                 345                 350         
Leu Lys Pro Glu Asn Ile Lys Lys Arg Asp Ala Lys Glu Ala Lys Ala
        355                 360                 365             
Gln Asn Glu Ala Thr Ser Thr Pro His Arg Ile Arg Arg Lys Ser Ser
    370                 375                 380                 
Val Leu Thr Met Asn Arg Ile Arg Gln Gln Leu Arg Phe Leu Gly Asn
385                 390                 395                 400 
Ser Lys Ser Asp Gln Glu Glu Lys Glu Ile Leu Pro Ala Ala Glu Ile
                405                 410                 415     
Ser Asp Ser Ser Ser Asp Glu Glu Glu Ala Ser Thr Pro Pro Leu Pro
            420                 425                 430         
Arg Arg Ala Pro Arg Thr Val Ser Arg Asn Leu Arg Ser Ser Leu Lys
        435                 440                 445             
Ser Ser Leu His Thr Leu Thr Lys Val Pro Lys Lys Ser Leu Lys Pro
    450                 455                 460                 
Arg Thr Pro Arg Cys Ala Ala Pro Gln Ile Arg Ser Arg Ser Leu Ala
465                 470                 475                 480 
Ala Gln Glu Pro Ala Ser Val Leu Glu Glu Ala Arg Leu Arg Leu His
                485                 490                 495     
Val Ser Ala Val Pro Glu Ser Leu Pro Cys Arg Glu Gln Glu Phe Gln
            500                 505                 510         
Asp Ile Tyr Asn Phe Val Glu Ser Lys Leu Leu Asp His Thr Gly Gly
        515                 520                 525             
Cys Met Tyr Ile Ser Gly Val Pro Gly Thr Gly Lys Thr Ala Thr Val
    530                 535                 540                 
His Glu Val Ile Arg Cys Leu Gln Gln Ala Ala Gln Ala Asn Asp Val
545                 550                 555                 560 
Pro Pro Phe Gln Tyr Ile Glu Val Asn Gly Met Lys Leu Thr Glu Pro
                565                 570                 575     
His Gln Val Tyr Val Gln Ile Leu Gln Lys Leu Thr Gly Gln Lys Ala
            580                 585                 590         
Thr Ala Asn His Ala Ala Glu Leu Leu Ala Lys Gln Phe Cys Thr Arg
        595                 600                 605             
Gly Ser Pro Gln Glu Thr Thr Val Leu Leu Val Asp Glu Leu Asp Leu
    610                 615                 620                 
Leu Trp Thr His Lys Gln Asp Ile Met Tyr Asn Leu Phe Asp Trp Pro
625                 630                 635                 640 
Thr His Lys Glu Ala Arg Leu Val Val Leu Ala Ile Ala Asn Thr Met
                645                 650                 655     
Asp Leu Pro Glu Arg Ile Met Met Asn Arg Val Ser Ser Arg Leu Gly
            660                 665                 670         
Leu Thr Arg Met Cys Phe Gln Pro Tyr Thr Tyr Ser Gln Leu Gln Gln
        675                 680                 685             
Ile Leu Arg Ser Arg Leu Lys His Leu Lys Ala Phe Glu Asp Asp Ala
    690                 695                 700                 
Ile Gln Leu Val Ala Arg Lys Val Ala Ala Leu Ser Gly Asp Ala Arg
705                 710                 715                 720 
Arg Cys Leu Asp Ile Cys Arg Arg Ala Thr Glu Ile Cys Glu Phe Ser
                725                 730                 735     
Gln Gln Lys Pro Asp Ser Pro Gly Leu Val Thr Ile Ala His Ser Met
            740                 745                 750         
Glu Ala Val Asp Glu Met Phe Ser Ser Ser Tyr Ile Thr Ala Ile Lys
        755                 760                 765             
Asn Ser Ser Val Leu Glu Gln Ser Phe Leu Arg Ala Ile Leu Ala Glu
    770                 775                 780                 
Phe Arg Arg Ser Gly Leu Glu Glu Ala Thr Phe Gln Gln Ile Tyr Ser
785                 790                 795                 800 
Gln His Val Ala Leu Cys Arg Met Glu Gly Leu Pro Tyr Pro Thr Met
                805                 810                 815     
Ser Glu Thr Met Ala Val Cys Ser His Leu Gly Ser Cys Arg Leu Leu
            820                 825                 830         
Leu Val Glu Pro Ser Arg Asn Asp Leu Leu Leu Arg Val Arg Leu Asn
        835                 840                 845             
Val Ser Gln Asp Asp Val Leu Tyr Ala Leu Lys Asp Glu
    850                 855                 860     


<210> 2299
<211> 386
<212> PRT
<213> Homo sapiens

<400> 2299
Met Val Cys Pro Pro Gly Glu Val Pro Val Phe Trp Pro Ser Pro Leu
 1               5                  10                  15      
Thr Ser Leu Gly Ala Val Ser Ser Cys Glu Thr Pro Leu Ala Phe Ala
            20                  25                  30          
Ser Ile Pro Gly Cys Thr Val Met Thr Asp Leu Lys Asp Ala Lys Ala
        35                  40                  45              
Pro Pro Gly Cys Leu Thr Pro Glu Arg Ile Pro Glu Val His His Ile
    50                  55                  60                  
Ser Gln Asp Pro Leu His Tyr Ser Ile Ala Ser Val Ser Ala Ser Gln
65                  70                  75                  80  
Lys Ile Arg Glu Leu Glu Ser Met Ile Gly Ile Asp Pro Val Leu Ile
                85                  90                  95      
Thr Thr Gly Phe Pro Thr His Phe Asn His Glu Pro Pro Glu Glu Thr
            100                 105                 110         
Asp Gly Pro Pro Gly Ala Val Ala Leu Val Ala Phe Leu Gln Ala Leu
        115                 120                 125             
Glu Lys Glu Val Ala Ile Ile Val Asp Gln Arg Ala Trp Asn Leu His
    130                 135                 140                 
Gln Lys Ile Val Glu Asp Ala Val Glu Gln Gly Val Leu Lys Thr Gln
145                 150                 155                 160 
Ile Pro Ile Leu Thr Tyr Gln Gly Gly Ser Val Glu Ala Ala Gln Ala
                165                 170                 175     
Phe Leu Cys Lys Asn Gly Asp Pro Gln Thr Pro Arg Phe Asp His Leu
            180                 185                 190         
Val Ala Ile Glu Arg Ala Gly Arg Ala Ala Asp Gly Asn Tyr Tyr Asn
        195                 200                 205             
Ala Arg Lys Met Asn Ile Lys His Leu Val Asp Pro Ile Asp Asp Leu
    210                 215                 220                 
Phe Leu Ala Ala Lys Lys Ile Pro Gly Ile Ser Ser Thr Gly Val Gly
225                 230                 235                 240 
Asp Gly Gly Asn Glu Leu Gly Met Gly Lys Val Lys Glu Ala Val Arg
                245                 250                 255     
Arg His Ile Arg His Gly Asp Val Ile Ala Cys Asp Val Glu Ala Asp
            260                 265                 270         
Phe Ala Val Ile Ala Gly Glu His Ser Asp Gly His Pro Val Arg Pro
        275                 280                 285             
Ala Thr Gln Gly Val Ser Asn Trp Gly Gly Tyr Ala Leu Ala Cys Ala
    290                 295                 300                 
Leu Tyr Ile Leu Tyr Ser Cys Ala Val His Ser Gln Tyr Leu Arg Lys
305                 310                 315                 320 
Ala Val Gly Pro Ser Arg Ala Pro Gly Asp Gln Ala Trp Thr Gln Ala
                325                 330                 335     
Leu Pro Ser Val Ile Lys Val Thr Asn Pro Ser Gln Pro Leu Ala Trp
            340                 345                 350         
Lys Gln Leu Leu Pro Trp Met Ser Ser Arg Pro Glu Val Pro Ser Arg
        355                 360                 365             
Lys Pro Arg Ala Gly Thr Leu Leu Pro Leu Lys Ser Gln Arg Gln Ser
    370                 375                 380                 
Gln Pro
385     


<210> 2300
<211> 469
<212> PRT
<213> Homo sapiens

<400> 2300
Met Gly Thr Val His Ala Arg Ser Leu Glu Pro Leu Pro Ser Ser Gly
 1               5                  10                  15      
Pro Asp Phe Gly Gly Leu Gly Glu Glu Ala Glu Phe Val Glu Val Glu
            20                  25                  30          
Pro Glu Ala Lys Gln Glu Ile Leu Glu Asn Lys Asp Val Val Val Gln
        35                  40                  45              
His Val His Phe Asp Gly Leu Gly Arg Thr Lys Asp Asp Ile Ile Ile
    50                  55                  60                  
Cys Glu Ile Gly Asp Val Phe Lys Ala Lys Asn Leu Ile Glu Val Met
65                  70                  75                  80  
Arg Lys Ser His Glu Ala Arg Glu Lys Leu Leu Arg Leu Gly Ile Phe
                85                  90                  95      
Arg Gln Val Asp Val Leu Ile Asp Thr Cys Gln Gly Asp Asp Ala Leu
            100                 105                 110         
Pro Asn Gly Leu Asp Val Thr Phe Glu Val Thr Glu Leu Arg Arg Leu
        115                 120                 125             
Thr Gly Ser Tyr Asn Thr Met Val Gly Asn Asn Glu Gly Ser Met Val
    130                 135                 140                 
Leu Gly Leu Lys Leu Pro Asn Leu Leu Gly Arg Ala Glu Lys Val Thr
145                 150                 155                 160 
Phe Gln Phe Ser Tyr Gly Thr Lys Glu Thr Ser Tyr Gly Leu Ser Phe
                165                 170                 175     
Phe Lys Pro Arg Pro Gly Asn Phe Glu Arg Asn Phe Ser Val Asn Leu
            180                 185                 190         
Tyr Lys Val Thr Gly Gln Phe Pro Trp Ser Ser Leu Arg Glu Thr Asp
        195                 200                 205             
Arg Gly Met Ser Ala Glu Tyr Ser Phe Pro Ile Trp Lys Thr Ser His
    210                 215                 220                 
Thr Val Lys Trp Glu Gly Val Trp Arg Glu Leu Gly Cys Leu Ser Arg
225                 230                 235                 240 
Thr Ala Ser Phe Ala Val Arg Lys Glu Ser Gly His Ser Leu Lys Ser
                245                 250                 255     
Ser Leu Ser His Ala Met Val Ile Asp Ser Arg Asn Ser Ser Ile Leu
            260                 265                 270         
Pro Arg Arg Gly Ala Leu Leu Lys Val Asn Gln Glu Leu Ala Gly Tyr
        275                 280                 285             
Thr Gly Gly Asp Val Ser Phe Ile Lys Glu Asp Phe Glu Leu Gln Leu
    290                 295                 300                 
Asn Lys Gln Leu Ile Phe Asp Ser Val Phe Ser Ala Ser Phe Trp Gly
305                 310                 315                 320 
Gly Met Leu Val Pro Ile Gly Asp Lys Pro Ser Ser Ile Ala Asp Arg
                325                 330                 335     
Phe Tyr Leu Gly Gly Pro Thr Ser Val Arg Gly Phe Ser Met His Ser
            340                 345                 350         
Ile Gly Pro Gln Ser Glu Gly Asp Tyr Leu Gly Gly Glu Ala Tyr Trp
        355                 360                 365             
Ala Gly Gly Leu His Leu Tyr Thr Pro Leu Pro Phe Arg Pro Gly Gln
    370                 375                 380                 
Gly Gly Phe Gly Glu Leu Phe Arg Thr His Phe Phe Leu Asn Ala Gly
385                 390                 395                 400 
Asn Leu Cys Asn Leu Asn Tyr Gly Glu Gly Pro Lys Ala His Ile Arg
                405                 410                 415     
Lys Leu Ala Glu Cys Ile Arg Trp Ser Tyr Gly Ala Gly Ile Val Leu
            420                 425                 430         
Arg Leu Gly Asn Ile Ala Arg Leu Glu Leu Asn Tyr Cys Val Pro Met
        435                 440                 445             
Gly Val Gln Thr Gly Asp Arg Ile Cys Asp Gly Val Gln Phe Gly Ala
    450                 455                 460                 
Gly Ile Arg Phe Leu
465                 


<210> 2301
<211> 492
<212> PRT
<213> Homo sapiens

<400> 2301
Met Gly Ser Ala Pro Trp Ala Pro Val Leu Leu Leu Ala Leu Gly Leu
 1               5                  10                  15      
Arg Gly Leu Gln Ala Gly Ala Arg Arg Ala Pro Asp Pro Gly Phe Gln
            20                  25                  30          
Glu Arg Phe Phe Gln Gln Arg Leu Asp His Phe Asn Phe Glu Arg Phe
        35                  40                  45              
Gly Asn Lys Thr Phe Pro Gln Arg Phe Leu Val Ser Asp Arg Phe Trp
    50                  55                  60                  
Val Arg Gly Glu Gly Pro Ile Phe Phe Tyr Thr Gly Asn Glu Gly Asp
65                  70                  75                  80  
Val Trp Ala Phe Ala Asn Asn Ser Gly Phe Val Ala Glu Leu Ala Ala
                85                  90                  95      
Glu Arg Gly Ala Leu Leu Val Phe Ala Glu His Arg Tyr Tyr Gly Lys
            100                 105                 110         
Ser Leu Pro Phe Gly Ala Gln Ser Thr Gln Arg Gly His Thr Glu Leu
        115                 120                 125             
Leu Thr Val Glu Gln Ala Leu Ala Asp Phe Ala Glu Leu Leu Arg Ala
    130                 135                 140                 
Leu Arg Arg Asp Leu Gly Ala Gln Asp Ala Pro Ala Ile Ala Phe Gly
145                 150                 155                 160 
Gly Ser Tyr Gly Gly Met Leu Ser Ala Tyr Leu Arg Met Lys Tyr Pro
                165                 170                 175     
His Leu Val Ala Gly Ala Leu Ala Ala Ser Ala Pro Val Leu Ala Val
            180                 185                 190         
Ala Gly Leu Gly Asp Ser Asn Gln Phe Phe Arg Asp Val Thr Ala Asp
        195                 200                 205             
Phe Glu Gly Gln Ser Pro Lys Cys Thr Gln Gly Val Arg Glu Ala Phe
    210                 215                 220                 
Arg Gln Ile Lys Asp Leu Phe Leu Gln Gly Ala Tyr Asp Thr Val Arg
225                 230                 235                 240 
Trp Glu Phe Gly Thr Cys Gln Pro Leu Ser Asp Glu Lys Asp Leu Thr
                245                 250                 255     
Gln Leu Phe Met Phe Ala Arg Asn Ala Phe Thr Val Leu Ala Met Met
            260                 265                 270         
Asp Tyr Pro Tyr Pro Thr Asp Phe Leu Gly Pro Leu Pro Ala Asn Pro
        275                 280                 285             
Val Lys Val Gly Cys Asp Arg Leu Leu Ser Glu Ala Gln Arg Ile Thr
    290                 295                 300                 
Gly Leu Arg Ala Leu Ala Gly Leu Val Tyr Asn Ala Ser Gly Ser Glu
305                 310                 315                 320 
His Cys Tyr Asp Ile Tyr Arg Leu Tyr His Ser Cys Ala Asp Pro Thr
                325                 330                 335     
Gly Cys Gly Thr Gly Pro Asp Ala Arg Ala Trp Asp Tyr Gln Ala Cys
            340                 345                 350         
Thr Glu Ile Asn Leu Thr Phe Ala Ser Asn Asn Val Thr Asp Met Phe
        355                 360                 365             
Pro Asp Leu Pro Phe Thr Asp Glu Leu Arg Gln Arg Tyr Cys Leu Asp
    370                 375                 380                 
Thr Trp Gly Val Trp Pro Arg Pro Asp Trp Leu Leu Thr Ser Phe Trp
385                 390                 395                 400 
Gly Gly Asp Leu Arg Ala Ala Ser Asn Ile Ile Phe Ser Asn Gly Asn
                405                 410                 415     
Leu Asp Pro Trp Ala Gly Gly Gly Ile Arg Arg Asn Leu Ser Ala Ser
            420                 425                 430         
Val Ile Ala Val Thr Ile Gln Gly Gly Ala His His Leu Asp Leu Arg
        435                 440                 445             
Ala Ser His Pro Glu Asp Pro Ala Ser Val Val Glu Ala Arg Lys Leu
    450                 455                 460                 
Glu Ala Thr Ile Ile Gly Glu Trp Val Lys Ala Ala Arg Arg Glu Gln
465                 470                 475                 480 
Gln Pro Ala Leu Arg Gly Gly Pro Arg Leu Ser Leu
                485                 490         


<210> 2302
<211> 343
<212> PRT
<213> Homo sapiens

<400> 2302
Met Leu Ala Thr Arg Leu Ser Arg Pro Leu Ser Arg Leu Pro Gly Lys
 1               5                  10                  15      
Thr Leu Ser Ala Cys Asp Arg Glu Asn Gly Ala Arg Arg Pro Leu Leu
            20                  25                  30          
Leu Gly Ser Thr Ser Phe Ile Pro Ile Gly Arg Arg Thr Tyr Ala Ser
        35                  40                  45              
Ala Ala Glu Pro Val Gly Ser Lys Ala Val Leu Val Thr Gly Cys Asp
    50                  55                  60                  
Ser Gly Phe Gly Phe Ala Leu Ala Lys His Leu His Ser Lys Gly Phe
65                  70                  75                  80  
Leu Val Phe Ala Gly Cys Leu Met Lys Asp Lys Gly His Asp Gly Val
                85                  90                  95      
Lys Glu Leu Asp Ser Leu Asn Ser Asp Arg Leu Arg Thr Val Gln Leu
            100                 105                 110         
Asn Val Cys Ser Ser Glu Glu Val Glu Lys Val Val Glu Ile Val Arg
        115                 120                 125             
Ser Ser Leu Lys Asp Pro Glu Lys Gly Met Trp Gly Leu Val Asn Asn
    130                 135                 140                 
Ala Gly Ile Ser Thr Phe Gly Glu Val Glu Phe Thr Ser Leu Glu Thr
145                 150                 155                 160 
Tyr Lys Gln Val Ala Glu Val Asn Leu Trp Gly Thr Val Arg Met Thr
                165                 170                 175     
Lys Ser Phe Leu Pro Leu Ile Arg Arg Ala Lys Gly Arg Val Val Asn
            180                 185                 190         
Ile Ser Ser Met Leu Gly Arg Met Ala Asn Pro Ala Arg Ser Pro Tyr
        195                 200                 205             
Cys Ile Thr Lys Phe Gly Val Glu Ala Phe Ser Asp Cys Leu Arg Tyr
    210                 215                 220                 
Glu Met Tyr Pro Leu Gly Val Lys Val Ser Val Val Glu Pro Gly Asn
225                 230                 235                 240 
Phe Ile Ala Ala Thr Ser Leu Tyr Ser Pro Glu Ser Ile Gln Ala Ile
                245                 250                 255     
Ala Lys Lys Met Trp Glu Glu Leu Pro Glu Val Val Arg Lys Asp Tyr
            260                 265                 270         
Gly Lys Lys Tyr Phe Asp Glu Lys Ile Ala Lys Met Glu Thr Tyr Cys
        275                 280                 285             
Ser Ser Gly Ser Thr Asp Thr Ser Pro Val Ile Asp Ala Val Thr His
    290                 295                 300                 
Ala Leu Thr Ala Thr Thr Pro Tyr Thr Arg Tyr His Pro Met Asp Tyr
305                 310                 315                 320 
Tyr Trp Trp Leu Arg Met Gln Ile Met Thr His Leu Pro Gly Ala Ile
                325                 330                 335     
Ser Asp Met Ile Tyr Ile Arg
            340             


<210> 2303
<211> 335
<212> PRT
<213> Homo sapiens

<400> 2303
Met Gly Ala Ser Ser Ser Ser Ala Leu Ala Arg Leu Gly Leu Pro Ala
 1               5                  10                  15      
Arg Pro Trp Pro Arg Trp Leu Gly Val Ala Ala Leu Gly Leu Ala Ala
            20                  25                  30          
Val Ala Leu Gly Thr Val Ala Trp Arg Arg Ala Trp Pro Arg Arg Arg
        35                  40                  45              
Arg Arg Leu Gln Gln Val Gly Thr Val Ala Lys Leu Trp Ile Tyr Pro
    50                  55                  60                  
Val Lys Ser Cys Lys Gly Val Pro Val Ser Glu Ala Glu Cys Thr Ala
65                  70                  75                  80  
Met Gly Leu Arg Ser Gly Asn Leu Arg Asp Arg Phe Trp Leu Val Ile
                85                  90                  95      
Lys Glu Asp Gly His Met Val Thr Ala Arg Gln Glu Pro Arg Leu Val
            100                 105                 110         
Leu Ile Ser Ile Ile Tyr Glu Asn Asn Cys Leu Ile Phe Arg Ala Pro
        115                 120                 125             
Asp Met Asp Gln Leu Val Leu Pro Ser Lys Gln Pro Ser Ser Asn Lys
    130                 135                 140                 
Leu His Asn Cys Arg Ile Phe Gly Leu Asp Ile Lys Gly Arg Asp Cys
145                 150                 155                 160 
Gly Asn Glu Ala Ala Lys Trp Phe Thr Asn Phe Leu Lys Thr Glu Ala
                165                 170                 175     
Tyr Arg Leu Val Gln Phe Glu Thr Asn Met Lys Gly Arg Thr Ser Arg
            180                 185                 190         
Lys Leu Leu Pro Thr Leu Asp Gln Asn Phe Gln Val Ala Tyr Pro Asp
        195                 200                 205             
Tyr Cys Pro Leu Leu Ile Met Thr Asp Ala Ser Leu Val Asp Leu Asn
    210                 215                 220                 
Thr Arg Met Glu Lys Lys Met Lys Met Glu Asn Phe Arg Pro Asn Ile
225                 230                 235                 240 
Val Val Thr Gly Cys Asp Ala Phe Glu Glu Asp Thr Trp Asp Glu Leu
                245                 250                 255     
Leu Ile Gly Ser Val Glu Val Lys Lys Val Met Ala Cys Pro Arg Cys
            260                 265                 270         
Ile Leu Thr Thr Val Asp Pro Asp Thr Gly Val Ile Asp Arg Lys Gln
        275                 280                 285             
Pro Leu Asp Thr Leu Lys Ser Tyr Arg Leu Cys Asp Pro Ser Glu Arg
    290                 295                 300                 
Glu Leu Tyr Lys Leu Ser Pro Leu Phe Gly Ile Tyr Tyr Ser Val Glu
305                 310                 315                 320 
Lys Ile Gly Ser Leu Arg Val Gly Asp Pro Val Tyr Arg Met Val
                325                 330                 335 


<210> 2304
<211> 418
<212> PRT
<213> Homo sapiens

<400> 2304
Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys
 1               5                  10                  15      
Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala
            20                  25                  30          
Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn
        35                  40                  45              
Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln
    50                  55                  60                  
Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser
65                  70                  75                  80  
Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr
                85                  90                  95      
His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro
            100                 105                 110         
Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn
        115                 120                 125             
Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu
    130                 135                 140                 
Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys
145                 150                 155                 160 
Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu
                165                 170                 175     
Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys
            180                 185                 190         
Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu
        195                 200                 205             
Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val
    210                 215                 220                 
Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Val Thr Thr Val
225                 230                 235                 240 
Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys
                245                 250                 255     
Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala
            260                 265                 270         
Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu
        275                 280                 285             
Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp
    290                 295                 300                 
Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr
305                 310                 315                 320 
Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe
                325                 330                 335     
Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys
            340                 345                 350         
Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly
        355                 360                 365             
Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile
    370                 375                 380                 
Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Asp
385                 390                 395                 400 
Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr
                405                 410                 415     
Gln Lys
        


<210> 2305
<211> 205
<212> PRT
<213> Homo sapiens

<400> 2305
Met Thr Glu Arg Arg Val Pro Phe Ser Leu Leu Arg Gly Pro Ser Trp
 1               5                  10                  15      
Asp Pro Phe Arg Asp Trp Tyr Pro His Ser Arg Leu Phe Asp Gln Ala
            20                  25                  30          
Phe Gly Leu Pro Arg Leu Pro Glu Glu Trp Ser Gln Trp Leu Gly Gly
        35                  40                  45              
Ser Ser Trp Pro Gly Tyr Val Arg Pro Leu Pro Pro Ala Ala Ile Glu
    50                  55                  60                  
Ser Pro Ala Val Ala Ala Pro Ala Tyr Ser Arg Ala Leu Ser Arg Gln
65                  70                  75                  80  
Leu Ser Ser Gly Val Ser Glu Ile Arg His Thr Ala Asp Arg Trp Arg
                85                  90                  95      
Val Ser Leu Asp Val Asn His Phe Ala Pro Asp Glu Arg Thr Val Lys
            100                 105                 110         
Thr Lys Asp Gly Val Val Glu Ile Ser Gly Lys His Glu Glu Leu Gln
        115                 120                 125             
Asp Glu His Gly Tyr Ile Ser Arg Cys Phe Thr Arg Lys Tyr Thr Leu
    130                 135                 140                 
Pro Pro Gly Val Asp Pro Thr Gln Val Ser Ser Ser Leu Ser Pro Glu
145                 150                 155                 160 
Gly Thr Leu Thr Val Glu Ala Pro Met Pro Lys Leu Ala Thr Gln Ser
                165                 170                 175     
Asn Glu Ile Thr Ile Pro Val Thr Phe Glu Ser Arg Ala Gln Leu Gly
            180                 185                 190         
Gly Pro Glu Ala Ala Lys Ser Asp Glu Thr Ala Ala Lys
        195                 200                 205 


<210> 2306
<211> 307
<212> PRT
<213> Homo sapiens

<400> 2306
Met Asn Thr Arg Asn Arg Val Val Asn Ser Gly Leu Gly Ala Ser Pro
 1               5                  10                  15      
Ala Ser Arg Pro Thr Arg Asp Pro Gln Asp Pro Ser Gly Arg Gln Gly
            20                  25                  30          
Glu Leu Ser Pro Val Glu Asp Gln Arg Glu Gly Leu Glu Ala Ala Pro
        35                  40                  45              
Lys Gly Pro Ser Arg Glu Ser Val Val His Ala Gly Gln Arg Arg Thr
    50                  55                  60                  
Ser Ala Tyr Thr Leu Ile Ala Pro Asn Ile Asn Arg Arg Asn Glu Ile
65                  70                  75                  80  
Gln Arg Ile Ala Glu Gln Glu Leu Ala Asn Leu Glu Lys Trp Lys Glu
                85                  90                  95      
Gln Asn Arg Ala Lys Pro Val His Leu Val Pro Arg Arg Leu Gly Gly
            100                 105                 110         
Ser Gln Ser Glu Thr Glu Val Arg Gln Lys Gln Gln Leu Gln Leu Met
        115                 120                 125             
Gln Ser Lys Tyr Lys Gln Lys Leu Lys Arg Glu Glu Ser Val Arg Ile
    130                 135                 140                 
Lys Lys Glu Ala Glu Glu Ala Glu Leu Gln Lys Met Lys Ala Ile Gln
145                 150                 155                 160 
Arg Glu Lys Ser Asn Lys Leu Glu Glu Lys Lys Arg Leu Gln Glu Asn
                165                 170                 175     
Leu Arg Arg Glu Ala Phe Arg Glu His Gln Gln Tyr Lys Thr Ala Glu
            180                 185                 190         
Phe Leu Ser Lys Leu Asn Thr Glu Ser Pro Asp Arg Ser Ala Cys Gln
        195                 200                 205             
Ser Ala Val Cys Gly Pro Gln Ser Ser Thr Trp Ala Arg Ser Trp Ala
    210                 215                 220                 
Tyr Arg Asp Ser Leu Lys Ala Glu Glu Asn Arg Lys Leu Gln Lys Met
225                 230                 235                 240 
Lys Asp Glu Gln His Gln Lys Ser Glu Leu Leu Glu Leu Lys Arg Gln
                245                 250                 255     
Gln Gln Glu Gln Glu Arg Ala Lys Ile His Gln Thr Glu His Arg Arg
            260                 265                 270         
Val Asn Asn Ala Phe Leu Asp Arg Leu Gln Gly Lys Ser Gln Pro Gly
        275                 280                 285             
Gly Leu Glu Gln Ser Gly Gly Cys Trp Asn Met Asn Ser Gly Asn Ser
    290                 295                 300                 
Trp Gly Ile
305         


<210> 2307
<211> 2799
<212> PRT
<213> Homo sapiens

<400> 2307
Met Thr Ser Ile His Phe Val Val His Pro Leu Pro Gly Thr Glu Asp
 1               5                  10                  15      
Gln Leu Asn Asp Arg Leu Arg Glu Val Ser Glu Lys Leu Asn Lys Tyr
            20                  25                  30          
Asn Leu Asn Ser His Pro Pro Leu Asn Val Leu Glu Gln Ala Thr Ile
        35                  40                  45              
Lys Gln Cys Val Val Gly Pro Asn His Ala Ala Phe Leu Leu Glu Asp
    50                  55                  60                  
Gly Arg Val Cys Arg Ile Gly Phe Ser Val Gln Pro Asp Arg Leu Glu
65                  70                  75                  80  
Leu Gly Lys Pro Asp Asn Asn Asp Gly Ser Lys Leu Asn Ser Asn Ser
                85                  90                  95      
Gly Ala Gly Arg Thr Ser Arg Pro Gly Arg Thr Ser Asp Ser Pro Trp
            100                 105                 110         
Phe Leu Ser Gly Ser Glu Thr Leu Gly Arg Leu Ala Gly Asn Thr Leu
        115                 120                 125             
Gly Ser Arg Trp Ser Ser Gly Val Gly Gly Ser Gly Gly Gly Ser Ser
    130                 135                 140                 
Gly Arg Ser Ser Ala Gly Ala Arg Asp Ser Arg Arg Gln Thr Arg Val
145                 150                 155                 160 
Ile Arg Thr Gly Arg Asp Arg Gly Ser Gly Leu Leu Gly Ser Gln Pro
                165                 170                 175     
Gln Pro Val Ile Pro Ala Ser Val Ile Pro Glu Glu Leu Ile Ser Gln
            180                 185                 190         
Ala Gln Val Val Leu Gln Gly Lys Ser Arg Ser Val Ile Ile Arg Glu
        195                 200                 205             
Leu Gln Arg Thr Asn Leu Asp Val Asn Leu Ala Val Asn Asn Leu Leu
    210                 215                 220                 
Ser Arg Asp Asp Glu Asp Gly Asp Asp Gly Asp Asp Thr Ala Ser Glu
225                 230                 235                 240 
Ser Tyr Leu Pro Gly Glu Asp Leu Met Ser Leu Leu Asp Ala Asp Ile
                245                 250                 255     
His Ser Ala His Pro Ser Val Ile Ile Asp Ala Asp Ala Met Phe Ser
            260                 265                 270         
Glu Asp Ile Ser Tyr Phe Gly Tyr Pro Ser Phe Arg Arg Ser Ser Leu
        275                 280                 285             
Ser Arg Leu Gly Ser Ser Arg Val Leu Leu Leu Pro Leu Glu Arg Asp
    290                 295                 300                 
Ser Glu Leu Leu Arg Glu Arg Glu Ser Val Leu Arg Leu Arg Glu Arg
305                 310                 315                 320 
Arg Trp Leu Asp Gly Ala Ser Phe Asp Asn Glu Arg Gly Ser Thr Ser
                325                 330                 335     
Lys Glu Gly Glu Pro Asn Leu Asp Lys Lys Asn Thr Pro Val Gln Ser
            340                 345                 350         
Pro Val Ser Leu Gly Glu Asp Leu Gln Trp Trp Pro Asp Lys Asp Gly
        355                 360                 365             
Thr Lys Phe Ile Cys Ile Gly Ala Leu Tyr Ser Glu Leu Leu Ala Val
    370                 375                 380                 
Ser Ser Lys Gly Glu Leu Tyr Gln Trp Lys Trp Ser Glu Ser Glu Pro
385                 390                 395                 400 
Tyr Arg Asn Ala Gln Asn Pro Ser Leu His His Pro Arg Ala Thr Phe
                405                 410                 415     
Leu Gly Leu Thr Asn Glu Lys Ile Val Leu Leu Ser Ala Asn Ser Ile
            420                 425                 430         
Arg Ala Thr Val Ala Thr Glu Asn Asn Lys Val Ala Thr Trp Val Asp
        435                 440                 445             
Glu Thr Leu Ser Ser Val Ala Ser Lys Leu Glu His Thr Ala Gln Thr
    450                 455                 460                 
Tyr Ser Glu Leu Gln Gly Glu Arg Ile Val Ser Leu His Cys Cys Ala
465                 470                 475                 480 
Leu Tyr Thr Cys Ala Gln Leu Glu Asn Ser Leu Tyr Trp Trp Gly Val
                485                 490                 495     
Val Pro Phe Ser Gln Arg Lys Lys Met Leu Glu Lys Ala Arg Ala Lys
            500                 505                 510         
Asn Lys Lys Pro Lys Ser Ser Ala Gly Ile Ser Ser Met Pro Asn Ile
        515                 520                 525             
Thr Val Gly Thr Gln Val Cys Leu Arg Asn Asn Pro Leu Tyr His Ala
    530                 535                 540                 
Gly Ala Val Ala Phe Ser Ile Ser Ala Gly Ile Pro Lys Val Gly Val
545                 550                 555                 560 
Leu Met Glu Ser Val Trp Asn Met Asn Asp Ser Cys Arg Phe Gln Leu
                565                 570                 575     
Arg Ser Pro Glu Ser Leu Lys Asn Met Glu Lys Ala Ser Lys Thr Thr
            580                 585                 590         
Glu Ala Lys Pro Glu Ser Lys Gln Glu Pro Val Lys Thr Glu Met Gly
        595                 600                 605             
Pro Pro Pro Ser Pro Ala Ser Thr Cys Ser Asp Ala Ser Ser Ile Ala
    610                 615                 620                 
Ser Ser Ala Ser Met Pro Tyr Lys Arg Arg Arg Ser Thr Pro Ala Pro
625                 630                 635                 640 
Lys Glu Glu Glu Lys Val Asn Glu Glu Gln Trp Ser Leu Arg Glu Val
                645                 650                 655     
Val Phe Val Glu Asp Val Lys Asn Val Pro Val Gly Lys Val Leu Lys
            660                 665                 670         
Val Asp Gly Ala Tyr Val Ala Val Lys Phe Pro Gly Thr Ser Ser Asn
        675                 680                 685             
Thr Asn Cys Gln Asn Ser Ser Gly Pro Asp Ala Asp Pro Ser Ser Leu
    690                 695                 700                 
Leu Gln Asp Cys Arg Leu Leu Arg Ile Asp Glu Leu Gln Val Val Lys
705                 710                 715                 720 
Thr Gly Gly Thr Pro Lys Val Pro Asp Cys Phe Gln Arg Thr Pro Lys
                725                 730                 735     
Lys Leu Cys Ile Pro Glu Lys Thr Glu Ile Leu Ala Val Asn Val Asp
            740                 745                 750         
Ser Lys Gly Val His Ala Val Leu Lys Thr Gly Asn Trp Val Arg Tyr
        755                 760                 765             
Cys Ile Phe Asp Leu Ala Thr Gly Lys Ala Glu Gln Glu Asn Asn Phe
    770                 775                 780                 
Pro Thr Ser Ser Ile Ala Phe Leu Gly Gln Asn Glu Arg Asn Val Ala
785                 790                 795                 800 
Ile Phe Thr Ala Gly Gln Glu Ser Pro Ile Ile Leu Arg Asp Gly Asn
                805                 810                 815     
Gly Thr Ile Tyr Pro Met Ala Lys Asp Cys Met Gly Gly Ile Arg Asp
            820                 825                 830         
Pro Asp Trp Leu Asp Leu Pro Pro Ile Ser Ser Leu Gly Met Gly Val
        835                 840                 845             
His Ser Leu Ile Asn Leu Pro Ala Asn Ser Thr Ile Lys Lys Lys Ala
    850                 855                 860                 
Ala Val Ile Ile Met Ala Val Glu Lys Gln Thr Leu Met Gln His Ile
865                 870                 875                 880 
Leu Arg Cys Asp Tyr Glu Ala Cys Arg Gln Tyr Leu Met Asn Leu Glu
                885                 890                 895     
Gln Ala Val Val Leu Glu Gln Asn Leu Gln Met Leu Gln Thr Phe Ile
            900                 905                 910         
Ser His Arg Cys Asp Gly Asn Arg Asn Ile Leu His Ala Cys Val Ser
        915                 920                 925             
Val Cys Phe Pro Thr Ser Asn Lys Glu Thr Lys Glu Glu Glu Glu Ala
    930                 935                 940                 
Glu Arg Ser Glu Arg Asn Thr Phe Ala Glu Arg Leu Ser Ala Val Glu
945                 950                 955                 960 
Ala Ile Ala Asn Ala Ile Ser Val Val Ser Ser Asn Gly Pro Gly Asn
                965                 970                 975     
Arg Ala Gly Ser Ser Ser Ser Arg Ser Leu Arg Leu Arg Glu Met Met
            980                 985                 990         
Arg Arg Ser Leu Arg Ala Ala Gly Leu Gly Arg His Glu Ala Gly Ala
        995                 1000                1005            
Ser Ser Ser Asp His Gln Asp Pro Val Ser Pro Pro Ile Ala Pro Pro
    1010                1015                1020                
Ser Trp Val Pro Asp Pro Pro Ala Met Asp Pro Asp Gly Asp Ile Asp
1025                1030                1035                1040
Phe Ile Leu Ala Pro Ala Val Gly Ser Leu Thr Thr Ala Ala Thr Gly
                1045                1050                1055    
Thr Gly Gln Gly Pro Ser Thr Ser Thr Ile Pro Gly Pro Ser Thr Glu
            1060                1065                1070        
Pro Ser Val Val Glu Ser Lys Asp Arg Lys Ala Asn Ala His Phe Ile
        1075                1080                1085            
Leu Lys Leu Leu Cys Asp Ser Val Val Leu Gln Pro Tyr Leu Arg Glu
    1090                1095                1100                
Leu Leu Ser Ala Lys Asp Ala Arg Gly Met Thr Pro Phe Met Ser Ala
1105                1110                1115                1120
Val Ser Gly Arg Ala Tyr Pro Ala Ala Ile Thr Ile Leu Glu Thr Ala
                1125                1130                1135    
Gln Lys Ile Ala Lys Ala Glu Ile Ser Ser Ser Glu Lys Glu Glu Asp
            1140                1145                1150        
Val Phe Met Gly Met Val Cys Pro Ser Gly Thr Asn Pro Asp Asp Ser
        1155                1160                1165            
Pro Leu Tyr Val Leu Cys Cys Asn Asp Thr Cys Ser Phe Thr Trp Thr
    1170                1175                1180                
Gly Ala Glu His Ile Asn Gln Asp Ile Phe Glu Cys Arg Thr Cys Gly
1185                1190                1195                1200
Leu Leu Glu Ser Leu Cys Cys Cys Thr Glu Cys Ala Arg Val Cys His
                1205                1210                1215    
Lys Gly His Asp Cys Lys Leu Lys Arg Thr Ser Pro Thr Ala Tyr Cys
            1220                1225                1230        
Asp Cys Trp Glu Lys Cys Lys Cys Lys Thr Leu Ile Ala Gly Gln Lys
        1235                1240                1245            
Ser Ala Arg Leu Asp Leu Leu Tyr Arg Leu Leu Thr Ala Thr Asn Leu
    1250                1255                1260                
Val Thr Leu Pro Asn Ser Arg Gly Glu His Leu Leu Leu Phe Leu Val
1265                1270                1275                1280
Gln Thr Val Ala Arg Gln Thr Val Glu His Cys Gln Tyr Arg Pro Pro
                1285                1290                1295    
Arg Ile Arg Glu Asp Arg Asn Arg Lys Thr Ala Ser Pro Glu Asp Ser
            1300                1305                1310        
Asp Met Pro Asp His Asp Leu Glu Pro Pro Arg Phe Ala Gln Leu Ala
        1315                1320                1325            
Leu Glu Arg Val Leu Gln Asp Trp Asn Ala Leu Lys Ser Met Ile Met
    1330                1335                1340                
Phe Gly Ser Gln Glu Asn Lys Asp Pro Leu Ser Ala Ser Ser Arg Ile
1345                1350                1355                1360
Gly His Leu Leu Pro Glu Glu Gln Val Tyr Leu Asn Gln Gln Ser Gly
                1365                1370                1375    
Thr Ile Arg Leu Asp Cys Phe Thr His Cys Leu Ile Val Lys Cys Thr
            1380                1385                1390        
Ala Asp Ile Leu Leu Leu Asp Thr Leu Leu Gly Thr Leu Val Lys Glu
        1395                1400                1405            
Leu Gln Asn Lys Tyr Thr Pro Gly Arg Arg Glu Glu Ala Ile Ala Val
    1410                1415                1420                
Thr Met Arg Phe Leu Arg Ser Val Ala Arg Val Phe Val Ile Leu Ser
1425                1430                1435                1440
Val Glu Met Ala Ser Ser Lys Lys Lys Asn Asn Phe Ile Pro Gln Pro
                1445                1450                1455    
Ile Gly Lys Cys Lys Arg Val Phe Gln Ala Leu Leu Pro Tyr Ala Val
            1460                1465                1470        
Glu Glu Leu Cys Asn Val Ala Glu Ser Leu Ile Val Pro Val Arg Met
        1475                1480                1485            
Gly Ile Ala Arg Pro Thr Ala Pro Phe Thr Leu Ala Ser Thr Ser Ile
    1490                1495                1500                
Asp Ala Met Gln Gly Ser Glu Glu Leu Phe Ser Val Glu Pro Leu Pro
1505                1510                1515                1520
Pro Arg Pro Ser Ser Asp Gln Ser Ser Ser Ser Ser Gln Ser Gln Ser
                1525                1530                1535    
Ser Tyr Ile Ile Arg Asn Pro Gln Gln Arg Arg Ile Ser Gln Ser Gln
            1540                1545                1550        
Pro Val Arg Gly Arg Asp Glu Glu Gln Asp Asp Ile Val Ser Ala Asp
        1555                1560                1565            
Val Glu Glu Val Glu Val Val Glu Gly Val Ala Gly Glu Glu Asp His
    1570                1575                1580                
His Asp Glu Gln Glu Glu His Gly Glu Glu Asn Ala Glu Ala Glu Gly
1585                1590                1595                1600
Gln His Asp Glu His Asp Glu Asp Gly Ser Asp Met Glu Leu Asp Leu
                1605                1610                1615    
Leu Ala Ala Ala Glu Thr Glu Ser Asp Ser Glu Ser Asn His Ser Asn
            1620                1625                1630        
Gln Asp Asn Ala Ser Gly Arg Arg Ser Val Val Thr Ala Ala Thr Ala
        1635                1640                1645            
Gly Ser Glu Ala Gly Ala Ser Ser Val Pro Ala Phe Phe Ser Glu Asp
    1650                1655                1660                
Asp Ser Gln Ser Asn Asp Ser Ser Asp Ser Asp Ser Ser Ser Ser Gln
1665                1670                1675                1680
Ser Asp Asp Ile Glu Gln Glu Thr Phe Met Leu Asp Glu Pro Leu Glu
                1685                1690                1695    
Arg Thr Thr Asn Ser Ser His Ala Asn Gly Ala Ala Gln Ala Pro Arg
            1700                1705                1710        
Ser Met Gln Trp Ala Val Arg Asn Thr Gln His Gln Arg Ala Ala Ser
        1715                1720                1725            
Thr Ala Pro Ser Ser Thr Ser Thr Pro Ala Ala Ser Ser Ala Gly Leu
    1730                1735                1740                
Ile Tyr Ile Asp Pro Ser Asn Leu Arg Arg Ser Gly Thr Ile Ser Thr
1745                1750                1755                1760
Ser Ala Ala Ala Ala Ala Ala Ala Leu Glu Ala Ser Asn Ala Ser Ser
                1765                1770                1775    
Tyr Leu Thr Ser Ala Ser Ser Leu Ala Arg Ala Tyr Ser Ile Val Ile
            1780                1785                1790        
Arg Gln Ile Ser Asp Leu Met Gly Leu Ile Pro Lys Tyr Asn His Leu
        1795                1800                1805            
Val Tyr Ser Gln Ile Pro Ala Ala Val Lys Leu Thr Tyr Gln Asp Ala
    1810                1815                1820                
Val Asn Leu Gln Asn Tyr Val Glu Glu Lys Leu Ile Pro Thr Trp Asn
1825                1830                1835                1840
Trp Met Val Ser Ile Met Asp Ser Thr Glu Ala Gln Leu Arg Tyr Gly
                1845                1850                1855    
Ser Ala Leu Ala Ser Ala Gly Asp Pro Gly His Pro Asn His Pro Leu
            1860                1865                1870        
His Ala Ser Gln Asn Ser Ala Arg Arg Glu Arg Met Thr Ala Arg Glu
        1875                1880                1885            
Glu Ala Ser Leu Arg Thr Leu Glu Gly Arg Arg Arg Ala Thr Leu Leu
    1890                1895                1900                
Ser Ala Arg Gln Gly Met Met Ser Ala Arg Gly Asp Phe Leu Asn Tyr
1905                1910                1915                1920
Ala Leu Ser Leu Met Arg Ser His Asn Asp Glu His Ser Asp Val Leu
                1925                1930                1935    
Pro Val Leu Asp Val Cys Ser Leu Lys His Val Ala Tyr Val Phe Gln
            1940                1945                1950        
Ala Leu Ile Tyr Trp Ile Lys Ala Met Asn Gln Gln Thr Thr Leu Asp
        1955                1960                1965            
Thr Pro Gln Leu Glu Arg Lys Arg Thr Arg Glu Leu Leu Glu Leu Gly
    1970                1975                1980                
Ile Asp Asn Glu Asp Ser Glu His Glu Asn Asp Asp Asp Thr Asn Gln
1985                1990                1995                2000
Ser Ala Thr Leu Asn Asp Lys Asp Asp Asp Ser Leu Pro Ala Glu Thr
                2005                2010                2015    
Gly Gln Asn His Pro Phe Phe Arg Arg Ser Asp Ser Met Thr Phe Leu
            2020                2025                2030        
Gly Cys Ile Pro Pro Asn Pro Phe Glu Val Pro Leu Ala Glu Ala Ile
        2035                2040                2045            
Pro Leu Ala Asp Gln Pro His Leu Leu Gln Pro Asn Ala Arg Lys Glu
    2050                2055                2060                
Asp Leu Phe Gly Arg Pro Ser Gln Gly Leu Tyr Ser Ser Ser Ala Ser
2065                2070                2075                2080
Ser Gly Lys Cys Leu Met Glu Val Thr Val Asp Arg Asn Cys Leu Glu
                2085                2090                2095    
Val Leu Pro Thr Lys Met Ser Tyr Ala Ala Asn Leu Lys Asn Val Met
            2100                2105                2110        
Asn Met Gln Asn Arg Gln Lys Lys Glu Gly Glu Glu Gln Pro Val Leu
        2115                2120                2125            
Pro Glu Glu Thr Glu Ser Ser Lys Pro Gly Pro Ser Ala His Asp Leu
    2130                2135                2140                
Ala Ala Gln Leu Lys Ser Ser Leu Leu Ala Glu Ile Gly Leu Thr Glu
2145                2150                2155                2160
Ser Glu Gly Pro Pro Leu Thr Ser Phe Arg Pro Gln Cys Ser Phe Met
                2165                2170                2175    
Gly Met Val Ile Ser His Asp Met Leu Leu Gly Arg Trp Arg Leu Ser
            2180                2185                2190        
Leu Glu Leu Phe Gly Arg Val Phe Met Glu Asp Val Gly Ala Glu Pro
        2195                2200                2205            
Gly Ser Ile Leu Thr Glu Leu Gly Gly Phe Glu Val Lys Glu Ser Lys
    2210                2215                2220                
Phe Arg Arg Glu Met Glu Lys Leu Arg Asn Gln Gln Ser Arg Asp Leu
2225                2230                2235                2240
Ser Leu Glu Val Asp Arg Asp Arg Asp Leu Leu Ile Gln Gln Thr Met
                2245                2250                2255    
Arg Gln Leu Asn Asn His Phe Gly Arg Arg Cys Ala Thr Thr Pro Met
            2260                2265                2270        
Ala Val His Arg Val Lys Val Thr Phe Lys Asp Glu Pro Gly Glu Gly
        2275                2280                2285            
Ser Gly Val Ala Arg Ser Phe Tyr Thr Ala Ile Ala Gln Ala Phe Leu
    2290                2295                2300                
Ser Asn Glu Lys Leu Pro Asn Leu Glu Cys Ile Gln Asn Ala Asn Lys
2305                2310                2315                2320
Gly Thr His Thr Ser Leu Met Gln Arg Leu Arg Asn Arg Gly Glu Arg
                2325                2330                2335    
Asp Arg Glu Arg Glu Arg Glu Arg Glu Met Arg Arg Ser Ser Gly Leu
            2340                2345                2350        
Arg Ala Gly Ser Arg Arg Asp Arg Asp Arg Asp Phe Arg Arg Gln Leu
        2355                2360                2365            
Ser Ile Asp Thr Arg Pro Phe Arg Pro Ala Ser Glu Gly Asn Pro Ser
    2370                2375                2380                
Asp Asp Pro Glu Pro Leu Pro Ala His Arg Gln Ala Leu Gly Glu Arg
2385                2390                2395                2400
Leu Tyr Pro Arg Val Gln Ala Met Gln Pro Ala Phe Ala Ser Lys Ile
                2405                2410                2415    
Thr Gly Met Leu Leu Glu Leu Ser Pro Ala Gln Leu Leu Leu Leu Leu
            2420                2425                2430        
Ala Ser Glu Asp Ser Leu Arg Ala Arg Val Asp Glu Ala Met Glu Leu
        2435                2440                2445            
Ile Ile Ala His Gly Arg Glu Asn Gly Ala Asp Ser Ile Leu Asp Leu
    2450                2455                2460                
Gly Leu Val Asp Ser Ser Glu Lys Val Gln Gln Glu Asn Arg Lys Arg
2465                2470                2475                2480
His Gly Ser Ser Arg Ser Val Val Asp Met Asp Leu Asp Asp Thr Asp
                2485                2490                2495    
Asp Gly Asp Asp Asn Ala Pro Leu Phe Tyr Gln Pro Gly Lys Arg Gly
            2500                2505                2510        
Phe Tyr Thr Pro Arg Pro Gly Lys Asn Thr Glu Ala Arg Leu Asn Cys
        2515                2520                2525            
Phe Arg Asn Ile Gly Arg Ile Leu Gly Leu Cys Leu Leu Gln Asn Glu
    2530                2535                2540                
Leu Cys Pro Ile Thr Leu Asn Arg His Val Ile Lys Val Leu Leu Gly
2545                2550                2555                2560
Arg Lys Val Asn Trp His Asp Phe Ala Phe Phe Asp Pro Val Met Tyr
                2565                2570                2575    
Glu Ser Leu Arg Gln Leu Ile Leu Ala Ser Gln Ser Ser Asp Ala Asp
            2580                2585                2590        
Ala Val Phe Ser Ala Met Asp Leu Ala Phe Ala Ile Asp Leu Cys Lys
        2595                2600                2605            
Glu Glu Gly Gly Gly Gln Val Glu Leu Ile Pro Asn Gly Val Asn Ile
    2610                2615                2620                
Pro Val Thr Pro Gln Asn Val Tyr Glu Tyr Val Arg Lys Tyr Ala Glu
2625                2630                2635                2640
His Arg Met Leu Val Val Ala Glu Gln Pro Leu His Ala Met Arg Lys
                2645                2650                2655    
Gly Leu Leu Asp Val Leu Pro Lys Asn Ser Leu Glu Asp Leu Thr Ala
            2660                2665                2670        
Glu Asp Phe Arg Leu Leu Val Asn Gly Cys Gly Glu Val Asn Val Gln
        2675                2680                2685            
Met Leu Ile Ser Phe Thr Ser Phe Asn Asp Glu Ser Gly Glu Asn Ala
    2690                2695                2700                
Glu Lys Leu Leu Gln Phe Lys Arg Trp Phe Trp Ser Ile Val Glu Lys
2705                2710                2715                2720
Met Ser Met Thr Glu Arg Gln Asp Leu Val Tyr Phe Trp Thr Ser Ser
                2725                2730                2735    
Pro Ser Leu Pro Ala Ser Glu Glu Gly Phe Gln Pro Met Pro Ser Ile
            2740                2745                2750        
Thr Ile Arg Pro Pro Asp Asp Gln His Leu Pro Thr Ala Asn Thr Cys
        2755                2760                2765            
Ile Ser Arg Leu Tyr Val Pro Leu Tyr Ser Ser Lys Gln Ile Leu Lys
    2770                2775                2780                
Gln Lys Leu Leu Leu Ala Ile Lys Thr Lys Asn Phe Gly Phe Val
2785                2790                2795                


<210> 2308
<211> 660
<212> PRT
<213> Homo sapiens

<400> 2308
Met Asp Val Leu Val Ser Glu Cys Ser Ala Arg Leu Leu Gln Gln Glu
 1               5                  10                  15      
Glu Glu Ile Lys Ser Leu Thr Ala Glu Ile Asp Arg Leu Lys Asn Cys
            20                  25                  30          
Gly Cys Leu Gly Ala Ser Pro Asn Leu Glu Gln Leu Gln Glu Glu Asn
        35                  40                  45              
Leu Lys Leu Lys Tyr Arg Leu Asn Ile Leu Arg Lys Ser Leu Gln Ala
    50                  55                  60                  
Glu Arg Asn Lys Pro Thr Lys Asn Met Ile Asn Ile Ile Ser Arg Leu
65                  70                  75                  80  
Gln Glu Val Phe Gly His Ala Ile Lys Ala Ala Tyr Pro Asp Leu Glu
                85                  90                  95      
Asn Pro Pro Leu Leu Val Thr Pro Ser Gln Gln Ala Lys Phe Gly Asp
            100                 105                 110         
Tyr Gln Cys Asn Ser Ala Met Gly Ile Ser Gln Met Leu Lys Thr Lys
        115                 120                 125             
Glu Gln Lys Val Asn Pro Arg Glu Ile Ala Glu Asn Ile Thr Lys His
    130                 135                 140                 
Leu Pro Asp Asn Glu Cys Ile Glu Lys Val Glu Ile Ala Gly Pro Gly
145                 150                 155                 160 
Phe Ile Asn Val His Leu Arg Lys Asp Phe Val Ser Glu Gln Leu Thr
                165                 170                 175     
Ser Leu Leu Val Asn Gly Val Gln Leu Pro Ala Leu Gly Glu Asn Lys
            180                 185                 190         
Lys Val Ile Val Asp Phe Ser Ser Pro Asn Ile Ala Lys Glu Met His
        195                 200                 205             
Val Gly His Leu Arg Ser Thr Ile Ile Gly Glu Ser Ile Ser Arg Leu
    210                 215                 220                 
Phe Glu Phe Ala Gly Tyr Asp Val Leu Arg Leu Asn His Val Gly Asp
225                 230                 235                 240 
Trp Gly Thr Gln Phe Gly Met Leu Ile Ala His Leu Gln Asp Lys Phe
                245                 250                 255     
Pro Asp Tyr Leu Thr Val Ser Pro Pro Ile Gly Asp Leu Gln Val Phe
            260                 265                 270         
Tyr Lys Glu Ser Lys Lys Arg Phe Asp Thr Glu Glu Glu Phe Lys Lys
        275                 280                 285             
Arg Ala Tyr Gln Cys Val Val Leu Leu Gln Gly Lys Asn Pro Asp Ile
    290                 295                 300                 
Thr Lys Ala Trp Lys Leu Ile Cys Asp Val Ser Arg Gln Glu Leu Asn
305                 310                 315                 320 
Lys Ile Tyr Asp Ala Leu Asp Val Ser Leu Ile Glu Arg Gly Glu Ser
                325                 330                 335     
Phe Tyr Gln Asp Arg Met Asn Asp Ile Val Lys Glu Phe Glu Asp Arg
            340                 345                 350         
Gly Phe Val Gln Val Asp Asp Gly Arg Lys Ile Val Phe Val Pro Gly
        355                 360                 365             
Cys Ser Ile Pro Leu Thr Ile Val Lys Ser Asp Gly Gly Tyr Thr Tyr
    370                 375                 380                 
Asp Thr Ser Asp Leu Ala Ala Ile Lys Gln Arg Leu Phe Glu Glu Lys
385                 390                 395                 400 
Ala Asp Met Ile Ile Tyr Val Val Asp Asn Gly Gln Ser Val His Phe
                405                 410                 415     
Gln Thr Ile Phe Ala Ala Ala Gln Met Ile Gly Trp Tyr Asp Pro Lys
            420                 425                 430         
Val Thr Arg Val Phe His Ala Gly Phe Gly Val Val Leu Gly Glu Asp
        435                 440                 445             
Lys Lys Lys Phe Lys Thr Arg Ser Gly Glu Thr Val Arg Leu Met Asp
    450                 455                 460                 
Leu Leu Gly Glu Gly Leu Lys Arg Ser Met Asp Lys Leu Lys Glu Lys
465                 470                 475                 480 
Glu Arg Asp Lys Val Leu Thr Ala Glu Glu Leu Asn Ala Ala Gln Thr
                485                 490                 495     
Ser Val Ala Tyr Gly Cys Ile Lys Tyr Ala Asp Leu Ser His Asn Arg
            500                 505                 510         
Leu Asn Asp Tyr Ile Phe Ser Phe Asp Lys Met Leu Asp Asp Arg Gly
        515                 520                 525             
Asn Thr Ala Ala Tyr Leu Leu Tyr Ala Phe Thr Arg Ile Arg Ser Ile
    530                 535                 540                 
Ala Arg Leu Ala Asn Ile Asp Glu Glu Met Leu Gln Lys Ala Ala Arg
545                 550                 555                 560 
Glu Thr Lys Ile Leu Leu Asp His Glu Lys Glu Trp Lys Leu Gly Arg
                565                 570                 575     
Cys Ile Leu Arg Phe Pro Glu Ile Leu Gln Lys Ile Leu Asp Asp Leu
            580                 585                 590         
Phe Leu His Thr Leu Cys Asp Tyr Ile Tyr Glu Leu Ala Thr Ala Phe
        595                 600                 605             
Thr Glu Phe Tyr Asp Ser Cys Tyr Cys Val Glu Lys Asp Arg Gln Thr
    610                 615                 620                 
Gly Lys Ile Leu Lys Val Asn Met Trp Arg Met Leu Leu Cys Glu Ala
625                 630                 635                 640 
Val Ala Ala Val Met Ala Lys Gly Phe Asp Ile Leu Gly Ile Lys Pro
                645                 650                 655     
Val Gln Arg Met
            660 


<210> 2309
<211> 103
<212> PRT
<213> Homo sapiens

<400> 2309
Met Met Gly Ser Lys Met Ala Ser Ala Ser Arg Val Val Gln Val Val
 1               5                  10                  15      
Lys Pro His Thr Pro Leu Ile Arg Phe Pro Asp Arg Arg Asp Asn Pro
            20                  25                  30          
Lys Pro Asn Val Ser Glu Ala Leu Arg Ser Ala Gly Leu Pro Ser His
        35                  40                  45              
Ser Ser Val Ile Ser Gln His Ser Lys Gly Ser Lys Ser Pro Asp Leu
    50                  55                  60                  
Leu Met Tyr Gln Gly Pro Pro Asp Thr Ala Glu Ile Ile Lys Thr Leu
65                  70                  75                  80  
Pro Gln Lys Tyr Arg Arg Lys Leu Val Ser Gln Glu Glu Met Glu Phe
                85                  90                  95      
Ile Gln Arg Gly Gly Pro Glu
            100             


<210> 2310
<211> 411
<212> PRT
<213> Homo sapiens

<400> 2310
Met Ala Leu Gln Ile Pro Pro Ser Ala Pro Ser Pro Leu Thr Ser Cys
 1               5                  10                  15      
Thr Trp Ala Gln Met Thr Phe Ser Thr Lys Thr Ser Lys Glu Asn Glu
            20                  25                  30          
Glu Asn Ile Gln Cys Gly Glu Asn Phe Met Asp Ile Glu Cys Phe Met
        35                  40                  45              
Val Leu Asn Pro Ser Gln Gln Leu Ala Ile Ala Val Leu Ser Leu Thr
    50                  55                  60                  
Leu Gly Thr Phe Thr Val Leu Glu Asn Leu Leu Val Leu Cys Val Ile
65                  70                  75                  80  
Leu His Ser Arg Ser Leu Arg Cys Arg Pro Ser Tyr His Phe Ile Gly
                85                  90                  95      
Ser Leu Ala Val Ala Asp Leu Leu Gly Ser Val Ile Phe Val Tyr Ser
            100                 105                 110         
Phe Ile Asp Phe His Val Phe His Arg Lys Asp Ser Arg Asn Val Phe
        115                 120                 125             
Leu Phe Lys Leu Gly Gly Val Thr Ala Ser Phe Thr Ala Ser Val Gly
    130                 135                 140                 
Ser Leu Phe Leu Thr Ala Ile Asp Arg Tyr Ile Ser Ile His Arg Pro
145                 150                 155                 160 
Leu Ala Tyr Lys Arg Ile Val Thr Arg Pro Lys Ala Val Val Ala Phe
                165                 170                 175     
Cys Leu Met Trp Thr Ile Ala Ile Val Ile Ala Val Leu Pro Leu Leu
            180                 185                 190         
Gly Trp Asn Cys Glu Lys Leu Gln Ser Val Cys Ser Asp Ile Phe Pro
        195                 200                 205             
His Ile Asp Glu Thr Tyr Leu Met Phe Trp Ile Gly Val Thr Ser Val
    210                 215                 220                 
Leu Leu Leu Phe Ile Val Tyr Ala Tyr Met Tyr Ile Leu Trp Lys Ala
225                 230                 235                 240 
His Ser His Ala Val Arg Met Ile Gln Arg Gly Thr Gln Lys Ser Ile
                245                 250                 255     
Ile Ile His Thr Ser Glu Asp Gly Lys Val Gln Val Thr Arg Pro Asp
            260                 265                 270         
Gln Ala Arg Met Asp Ile Arg Leu Ala Lys Thr Leu Val Leu Ile Leu
        275                 280                 285             
Val Val Leu Ile Ile Cys Trp Gly Pro Leu Leu Ala Ile Met Val Tyr
    290                 295                 300                 
Asp Val Phe Gly Lys Met Asn Lys Leu Ile Lys Thr Val Phe Ala Phe
305                 310                 315                 320 
Cys Ser Met Leu Cys Leu Leu Asn Ser Thr Val Asn Pro Ile Ile Tyr
                325                 330                 335     
Ala Leu Arg Ser Lys Asp Leu Arg His Ala Phe Arg Ser Met Phe Pro
            340                 345                 350         
Ser Cys Glu Gly Thr Ala Gln Pro Leu Asp Asn Ser Met Gly Asp Ser
        355                 360                 365             
Asp Cys Leu His Lys His Ala Asn Asn Ala Ala Ser Val His Arg Ala
    370                 375                 380                 
Ala Glu Ser Cys Ile Lys Ser Thr Val Lys Ile Ala Lys Val Thr Met
385                 390                 395                 400 
Ser Val Ser Thr Asp Thr Ser Ala Glu Ala Leu
                405                 410     


<210> 2311
<211> 368
<212> PRT
<213> Homo sapiens

<400> 2311
Met Ala Ala Cys Thr Ala Arg Arg Pro Leu Ala Val Gly Ser Arg Trp
 1               5                  10                  15      
Trp Ser Arg Ser Leu Thr Gly Ala Arg Trp Pro Lys Pro Leu Cys Ala
            20                  25                  30          
Ala Ala Gly Ala Gly Ala Phe Ser Pro Ala Ser Thr Thr Thr Thr Arg
        35                  40                  45              
Arg His Leu Ser Ser Arg Asn Arg Pro Glu Gly Lys Val Leu Glu Thr
    50                  55                  60                  
Val Gly Val Phe Glu Val Pro Lys Gln Asn Gly Lys Tyr Glu Thr Gly
65                  70                  75                  80  
Gln Leu Phe Leu His Ser Ile Phe Gly Tyr Arg Gly Val Val Leu Phe
                85                  90                  95      
Pro Trp Gln Ala Arg Leu Tyr Asp Arg Asp Val Ala Ser Ala Ala Pro
            100                 105                 110         
Glu Lys Ala Glu Asn Pro Ala Gly His Gly Ser Lys Glu Val Lys Gly
        115                 120                 125             
Lys Thr His Thr Tyr Tyr Gln Val Leu Ile Asp Ala Arg Asp Cys Pro
    130                 135                 140                 
His Ile Ser Gln Arg Ser Gln Thr Glu Ala Val Thr Phe Leu Ala Asn
145                 150                 155                 160 
His Asp Asp Ser Arg Ala Leu Tyr Ala Ile Pro Gly Leu Asp Tyr Val
                165                 170                 175     
Ser His Glu Asp Ile Leu Pro Tyr Thr Ser Thr Asp Gln Val Pro Ile
            180                 185                 190         
Gln His Glu Leu Phe Glu Arg Phe Leu Leu Tyr Asp Gln Thr Lys Ala
        195                 200                 205             
Pro Pro Phe Val Ala Arg Glu Thr Leu Arg Ala Trp Gln Glu Lys Asn
    210                 215                 220                 
His Pro Trp Leu Glu Leu Ser Asp Val His Arg Glu Thr Thr Glu Asn
225                 230                 235                 240 
Ile Arg Val Thr Val Ile Pro Phe Tyr Met Gly Met Arg Glu Ala Gln
                245                 250                 255     
Asn Ser His Val Tyr Trp Trp Arg Tyr Cys Ile Arg Leu Glu Asn Leu
            260                 265                 270         
Asp Ser Asp Val Val Gln Leu Arg Glu Arg His Trp Arg Ile Phe Ser
        275                 280                 285             
Leu Ser Gly Thr Leu Glu Thr Val Arg Gly Arg Gly Val Val Gly Arg
    290                 295                 300                 
Glu Pro Val Leu Ser Lys Glu Gln Pro Ala Phe Gln Tyr Ser Ser His
305                 310                 315                 320 
Val Ser Leu Gln Ala Ser Ser Gly His Met Trp Gly Thr Phe Arg Phe
                325                 330                 335     
Glu Arg Pro Asp Gly Ser His Phe Asp Val Arg Ile Pro Pro Phe Ser
            340                 345                 350         
Leu Glu Ser Asn Lys Asp Glu Lys Thr Pro Pro Ser Gly Leu His Trp
        355                 360                 365             


<210> 2312
<211> 2596
<212> PRT
<213> Homo sapiens

<400> 2312
Met Asp Gln Thr Cys Glu Leu Pro Arg Arg Asn Cys Leu Leu Pro Phe
 1               5                  10                  15      
Ser Asn Pro Val Asn Leu Asp Ala Pro Glu Asp Lys Asp Ser Pro Phe
            20                  25                  30          
Gly Asn Gly Gln Ser Asn Phe Ser Glu Pro Leu Asn Gly Cys Thr Met
        35                  40                  45              
Gln Leu Ser Thr Val Ser Gly Thr Ser Gln Asn Ala Tyr Gly Gln Asp
    50                  55                  60                  
Ser Pro Ser Cys Tyr Ile Pro Leu Arg Arg Leu Gln Asp Leu Ala Ser
65                  70                  75                  80  
Met Ile Asn Val Glu Tyr Leu Asn Gly Ser Ala Asp Gly Ser Glu Ser
                85                  90                  95      
Phe Gln Asp Pro Glu Lys Ser Asp Ser Arg Ala Gln Thr Pro Ile Val
            100                 105                 110         
Cys Thr Ser Leu Ser Pro Gly Gly Pro Thr Ala Leu Ala Met Lys Gln
        115                 120                 125             
Glu Pro Ser Cys Asn Asn Ser Pro Glu Leu Gln Val Lys Val Thr Lys
    130                 135                 140                 
Thr Ile Lys Asn Gly Phe Leu His Phe Glu Asn Phe Thr Cys Val Asp
145                 150                 155                 160 
Asp Ala Asp Val Asp Ser Glu Met Asp Pro Glu Gln Pro Val Thr Glu
                165                 170                 175     
Asp Glu Ser Ile Glu Glu Ile Phe Glu Glu Thr Gln Thr Asn Ala Thr
            180                 185                 190         
Cys Asn Tyr Glu Thr Lys Ser Glu Asn Gly Val Lys Val Ala Met Gly
        195                 200                 205             
Ser Glu Gln Asp Ser Thr Pro Glu Ser Arg His Gly Ala Val Lys Ser
    210                 215                 220                 
Pro Phe Leu Pro Leu Ala Pro Gln Thr Glu Thr Gln Lys Asn Lys Gln
225                 230                 235                 240 
Arg Asn Glu Val Asp Gly Ser Asn Glu Lys Ala Ala Leu Leu Pro Ala
                245                 250                 255     
Pro Phe Ser Leu Gly Asp Thr Asn Ile Thr Ile Glu Glu Gln Leu Asn
            260                 265                 270         
Ser Ile Asn Leu Ser Phe Gln Asp Asp Pro Asp Ser Ser Thr Ser Thr
        275                 280                 285             
Leu Gly Asn Met Leu Glu Leu Pro Gly Thr Ser Ser Ser Ser Thr Ser
    290                 295                 300                 
Gln Glu Leu Pro Phe Val Pro Gln Lys Ile Leu Ser Lys Trp Glu Ala
305                 310                 315                 320 
Ser Val Gly Leu Ala Glu Gln Tyr Asp Val Pro Lys Gly Ser Lys Asn
                325                 330                 335     
Arg Lys Cys Ile Pro Gly Ser Ile Lys Leu Asp Ser Glu Glu Asp Met
            340                 345                 350         
Pro Phe Glu Asp Cys Thr Asn Asp Pro Glu Ser Glu His Asp Leu Leu
        355                 360                 365             
Leu Asn Gly Cys Leu Lys Ser Leu Ala Phe Asp Ser Glu His Ser Ala
    370                 375                 380                 
Asp Glu Lys Glu Lys Pro Cys Ala Lys Ser Arg Ala Arg Lys Ser Ser
385                 390                 395                 400 
Asp Asn Pro Lys Arg Thr Ser Val Lys Lys Gly His Ile Gln Phe Glu
                405                 410                 415     
Ala His Lys Asp Glu Arg Arg Gly Lys Ile Pro Glu Asn Leu Gly Leu
            420                 425                 430         
Asn Phe Ile Ser Gly Asp Ile Ser Asp Thr Gln Ala Ser Asn Glu Leu
        435                 440                 445             
Ser Arg Ile Ala Asn Ser Leu Thr Gly Ser Asn Thr Ala Pro Gly Ser
    450                 455                 460                 
Phe Leu Phe Ser Ser Cys Gly Lys Asn Thr Ala Lys Lys Glu Phe Glu
465                 470                 475                 480 
Thr Ser Asn Gly Asp Ser Leu Leu Gly Leu Pro Glu Gly Ala Leu Ile
                485                 490                 495     
Ser Lys Cys Ser Arg Glu Lys Asn Lys Pro Gln Arg Ser Leu Val Cys
            500                 505                 510         
Gly Ser Lys Val Lys Leu Cys Tyr Ile Gly Ala Gly Asp Glu Glu Lys
        515                 520                 525             
Arg Ser Asp Ser Ile Ser Ile Cys Thr Thr Ser Asp Asp Gly Ser Ser
    530                 535                 540                 
Asp Leu Asp Pro Ile Glu His Ser Ser Glu Ser Asp Asn Ser Val Leu
545                 550                 555                 560 
Glu Ile Pro Asp Ala Phe Asp Arg Thr Glu Asn Met Leu Ser Met Gln
                565                 570                 575     
Lys Asn Glu Lys Ile Lys Tyr Ser Arg Phe Ala Ala Thr Asn Thr Arg
            580                 585                 590         
Val Lys Ala Lys Gln Lys Pro Leu Ile Ser Asn Ser His Thr Asp His
        595                 600                 605             
Leu Met Gly Cys Thr Lys Ser Ala Glu Pro Gly Thr Glu Thr Ser Gln
    610                 615                 620                 
Val Asn Leu Ser Asp Leu Lys Ala Ser Thr Leu Val His Lys Pro Gln
625                 630                 635                 640 
Ser Asp Phe Thr Asn Asp Ala Leu Ser Pro Lys Phe Asn Leu Ser Ser
                645                 650                 655     
Ser Ile Ser Ser Glu Asn Ser Leu Ile Lys Gly Gly Ala Ala Asn Gln
            660                 665                 670         
Ala Leu Leu His Ser Lys Ser Lys Gln Pro Lys Phe Arg Ser Ile Lys
        675                 680                 685             
Cys Lys His Lys Glu Asn Pro Val Met Ala Glu Pro Pro Val Ile Asn
    690                 695                 700                 
Glu Glu Cys Ser Leu Lys Cys Cys Ser Ser Asp Thr Lys Gly Ser Pro
705                 710                 715                 720 
Leu Ala Ser Ile Ser Lys Ser Gly Lys Val Asp Gly Leu Lys Leu Leu
                725                 730                 735     
Asn Asn Met His Glu Lys Thr Arg Asp Ser Ser Asp Ile Glu Thr Ala
            740                 745                 750         
Val Val Lys His Val Leu Ser Glu Leu Lys Glu Leu Ser Tyr Arg Ser
        755                 760                 765             
Leu Gly Glu Asp Val Ser Asp Ser Gly Thr Ser Lys Pro Ser Lys Pro
    770                 775                 780                 
Leu Leu Phe Ser Ser Ala Ser Ser Gln Asn His Ile Pro Ile Glu Pro
785                 790                 795                 800 
Asp Tyr Lys Phe Ser Thr Leu Leu Met Met Leu Lys Asp Met His Asp
                805                 810                 815     
Ser Lys Thr Lys Glu Gln Arg Leu Met Thr Ala Gln Asn Leu Val Ser
            820                 825                 830         
Tyr Arg Ser Pro Gly Arg Gly Asp Cys Ser Thr Asn Ser Pro Val Gly
        835                 840                 845             
Val Ser Lys Val Leu Val Ser Gly Gly Ser Thr His Asn Ser Glu Lys
    850                 855                 860                 
Lys Gly Asp Gly Thr Gln Asn Ser Ala Asn Pro Ser Pro Ser Gly Gly
865                 870                 875                 880 
Asp Ser Ala Leu Ser Gly Glu Leu Ser Ala Ser Leu Pro Gly Leu Leu
                885                 890                 895     
Ser Asp Lys Arg Asp Leu Pro Ala Ser Gly Lys Ser Arg Ser Asp Cys
            900                 905                 910         
Val Thr Arg Arg Asn Cys Gly Arg Ser Lys Pro Ser Ser Lys Leu Arg
        915                 920                 925             
Asp Ala Phe Ser Ala Gln Met Val Lys Asn Thr Val Asn Arg Lys Ala
    930                 935                 940                 
Leu Lys Thr Glu Arg Lys Arg Lys Leu Asn Gln Leu Pro Ser Val Thr
945                 950                 955                 960 
Leu Asp Ala Val Leu Gln Gly Asp Arg Glu Arg Gly Gly Ser Leu Arg
                965                 970                 975     
Gly Gly Ala Glu Asp Pro Ser Lys Glu Asp Pro Leu Gln Ile Met Gly
            980                 985                 990         
His Leu Thr Ser Glu Asp Gly Asp His Phe Ser Asp Val His Phe Asp
        995                 1000                1005            
Ser Lys Val Lys Gln Ser Asp Pro Gly Lys Ile Ser Glu Lys Gly Leu
    1010                1015                1020                
Ser Phe Glu Asn Gly Lys Gly Pro Glu Leu Asp Ser Val Met Asn Ser
1025                1030                1035                1040
Glu Asn Asp Glu Leu Asn Gly Val Asn Gln Val Val Pro Lys Lys Arg
                1045                1050                1055    
Trp Gln Arg Leu Asn Gln Arg Arg Thr Lys Pro Arg Lys Arg Met Asn
            1060                1065                1070        
Arg Phe Lys Glu Lys Glu Asn Ser Glu Cys Ala Phe Arg Val Leu Leu
        1075                1080                1085            
Pro Ser Asp Pro Val Gln Glu Gly Arg Asp Glu Phe Pro Glu His Arg
    1090                1095                1100                
Thr Pro Ser Ala Ser Ile Leu Glu Glu Pro Leu Thr Glu Gln Asn His
1105                1110                1115                1120
Ala Asp Cys Leu Asp Ser Ala Gly Pro Arg Leu Asn Val Cys Asp Lys
                1125                1130                1135    
Ser Ser Ala Ser Ile Gly Asp Met Glu Lys Glu Pro Gly Ile Pro Ser
            1140                1145                1150        
Leu Thr Pro Gln Ala Glu Leu Pro Glu Pro Ala Val Arg Ser Glu Lys
        1155                1160                1165            
Lys Arg Leu Arg Lys Pro Ser Lys Trp Leu Leu Glu Tyr Thr Glu Glu
    1170                1175                1180                
Tyr Asp Gln Ile Phe Ala Pro Lys Lys Lys Gln Lys Lys Val Gln Glu
1185                1190                1195                1200
Gln Val Asp Lys Val Ser Ser Arg Cys Glu Glu Glu Ser Leu Leu Ala
                1205                1210                1215    
Arg Gly Arg Ser Ser Ala Gln Asn Lys Gln Val Asp Glu Asn Ser Leu
            1220                1225                1230        
Ile Ser Thr Lys Glu Glu Pro Pro Val Leu Glu Arg Glu Ala Pro Phe
        1235                1240                1245            
Leu Glu Gly Pro Leu Ala Gln Ser Glu Leu Gly Gly Gly His Ala Glu
    1250                1255                1260                
Leu Pro Gln Leu Thr Leu Ser Val Pro Val Ala Pro Glu Val Ser Pro
1265                1270                1275                1280
Arg Pro Ala Leu Glu Ser Glu Glu Leu Leu Val Lys Thr Gln Gly Asn
                1285                1290                1295    
Tyr Glu Ser Lys Arg Gln Arg Lys Pro Thr Lys Lys Leu Leu Glu Ser
            1300                1305                1310        
Asn Asp Leu Asp Pro Gly Phe Met Pro Lys Lys Gly Asp Leu Gly Leu
        1315                1320                1325            
Ser Lys Lys Cys Tyr Glu Ala Gly His Leu Glu Asn Gly Ile Thr Glu
    1330                1335                1340                
Ser Cys Ala Thr Ser Tyr Ser Lys Asp Phe Gly Gly Gly Thr Thr Lys
1345                1350                1355                1360
Ile Phe Asp Lys Pro Arg Lys Arg Lys Arg Gln Arg His Ala Val Ala
                1365                1370                1375    
Lys Met Gln Cys Lys Lys Val Lys Asn Asp Asp Ser Ser Lys Glu Ile
            1380                1385                1390        
Pro Gly Ser Glu Gly Glu Leu Met Pro His Arg Thr Ala Thr Ser Pro
        1395                1400                1405            
Lys Glu Thr Val Glu Glu Gly Val Glu His Asp Pro Gly Met Pro Ala
    1410                1415                1420                
Ser Lys Lys Met Gln Gly Glu Arg Gly Gly Gly Ala Ala Leu Lys Glu
1425                1430                1435                1440
Asn Val Cys Gln Asn Cys Glu Lys Leu Gly Glu Leu Leu Leu Cys Glu
                1445                1450                1455    
Ala Gln Cys Cys Gly Ala Phe His Leu Glu Cys Leu Gly Leu Thr Glu
            1460                1465                1470        
Met Pro Arg Gly Lys Phe Ile Cys Asn Glu Cys Arg Thr Gly Ile His
        1475                1480                1485            
Thr Cys Phe Val Cys Lys Gln Ser Gly Glu Asp Val Lys Arg Cys Leu
    1490                1495                1500                
Leu Pro Leu Cys Gly Lys Phe Tyr His Glu Glu Cys Val Gln Lys Tyr
1505                1510                1515                1520
Pro Pro Thr Val Met Gln Asn Lys Gly Phe Arg Cys Ser Leu His Ile
                1525                1530                1535    
Cys Ile Thr Cys His Ala Ala Asn Pro Ala Asn Val Ser Ala Ser Lys
            1540                1545                1550        
Gly Arg Leu Met Arg Cys Val Arg Cys Pro Val Ala Tyr His Ala Asn
        1555                1560                1565            
Asp Phe Cys Leu Ala Ala Gly Ser Lys Ile Leu Ala Ser Asn Ser Ile
    1570                1575                1580                
Ile Cys Pro Asn His Phe Thr Pro Arg Arg Gly Cys Arg Asn His Glu
1585                1590                1595                1600
His Val Asn Val Ser Trp Cys Phe Val Cys Ser Glu Gly Gly Ser Leu
                1605                1610                1615    
Leu Cys Cys Asp Ser Cys Pro Ala Ala Phe His Arg Glu Cys Leu Asn
            1620                1625                1630        
Ile Asp Ile Pro Glu Gly Asn Trp Tyr Cys Asn Asp Cys Lys Ala Gly
        1635                1640                1645            
Lys Lys Pro His Tyr Arg Glu Ile Val Trp Val Lys Val Gly Arg Tyr
    1650                1655                1660                
Arg Trp Trp Pro Ala Glu Ile Cys His Pro Arg Ala Val Pro Ser Asn
1665                1670                1675                1680
Ile Asp Lys Met Arg His Asp Val Gly Glu Phe Pro Val Leu Phe Phe
                1685                1690                1695    
Gly Ser Asn Asp Tyr Leu Trp Thr His Gln Ala Arg Val Phe Pro Tyr
            1700                1705                1710        
Met Glu Gly Asp Val Ser Ser Lys Asp Lys Met Gly Lys Gly Val Asp
        1715                1720                1725            
Gly Thr Tyr Lys Lys Ala Leu Gln Glu Ala Ala Ala Arg Phe Glu Glu
    1730                1735                1740                
Leu Lys Ala Gln Lys Glu Leu Arg Gln Leu Gln Glu Asp Arg Lys Asn
1745                1750                1755                1760
Asp Lys Lys Pro Pro Pro Tyr Lys His Ile Lys Val Asn Arg Pro Ile
                1765                1770                1775    
Gly Arg Val Gln Ile Phe Thr Ala Asp Leu Ser Glu Ile Pro Arg Cys
            1780                1785                1790        
Asn Cys Lys Ala Thr Asp Glu Asn Pro Cys Gly Ile Asp Ser Glu Cys
        1795                1800                1805            
Ile Asn Arg Met Leu Leu Tyr Glu Cys His Pro Thr Val Cys Pro Ala
    1810                1815                1820                
Gly Gly Arg Cys Gln Asn Gln Cys Phe Ser Lys Arg Gln Tyr Pro Glu
1825                1830                1835                1840
Val Glu Ile Phe Arg Thr Leu Gln Arg Gly Trp Gly Leu Arg Thr Gln
                1845                1850                1855    
Glu Asp Ile Arg Lys Gly Glu Phe Val Asn Glu Tyr Val Gly Glu Leu
            1860                1865                1870        
Ile Asp Glu Glu Glu Cys Met Ala Arg Ile Lys His Ala His Glu Asn
        1875                1880                1885            
Asp Ile Thr His Phe Tyr Met Leu Thr Ile Asp Lys Asp Arg Ile Ile
    1890                1895                1900                
Asp Ala Gly Pro Lys Gly Asn Tyr Ser Arg Phe Met Asn His Ser Cys
1905                1910                1915                1920
Gln Pro Asn Cys Glu Thr Leu Lys Trp Thr Val Asn Gly Asp Thr Arg
                1925                1930                1935    
Val Gly Leu Phe Ala Val Cys Asp Ile Pro Ala Gly Thr Glu Leu Thr
            1940                1945                1950        
Phe Asn Tyr Asn Leu Asp Cys Leu Gly Asn Glu Lys Thr Val Cys Arg
        1955                1960                1965            
Cys Gly Ala Ser Asn Cys Ser Gly Phe Leu Gly Val Arg Pro Lys Asn
    1970                1975                1980                
Gln Pro Ile Ala Thr Glu Glu Lys Ser Lys Lys Phe Lys Lys Lys Gln
1985                1990                1995                2000
Gln Gly Lys Arg Arg Thr Gln Gly Glu Ile Thr Lys Glu Arg Glu Asp
                2005                2010                2015    
Glu Cys Phe Ser Cys Gly Asp Ala Gly Gln Leu Val Ser Cys Lys Lys
            2020                2025                2030        
Pro Gly Cys Pro Lys Val Tyr His Ala Asp Cys Leu Asn Leu Thr Lys
        2035                2040                2045            
Arg Pro Ala Gly Lys Trp Glu Cys Pro Trp His Gln Cys Asp Ile Cys
    2050                2055                2060                
Gly Lys Glu Ala Ala Ser Phe Cys Glu Met Cys Pro Ser Ser Phe Cys
2065                2070                2075                2080
Lys Gln His Arg Glu Gly Met Leu Phe Ile Ser Lys Leu Asp Gly Arg
                2085                2090                2095    
Leu Ser Cys Thr Glu His Asp Pro Cys Gly Pro Asn Pro Leu Glu Pro
            2100                2105                2110        
Gly Glu Ile Arg Glu Tyr Val Pro Pro Pro Val Pro Leu Pro Pro Gly
        2115                2120                2125            
Pro Ser Thr His Leu Ala Glu Gln Ser Thr Gly Met Ala Ala Gln Ala
    2130                2135                2140                
Pro Lys Met Ser Asp Lys Pro Pro Ala Asp Thr Asn Gln Met Leu Ser
2145                2150                2155                2160
Leu Ser Lys Lys Ala Leu Ala Gly Thr Cys Gln Arg Pro Leu Leu Pro
                2165                2170                2175    
Glu Arg Pro Leu Glu Arg Thr Asp Ser Arg Pro Gln Pro Leu Asp Lys
            2180                2185                2190        
Val Arg Asp Leu Ala Gly Ser Gly Ala Gln Ser Gln Ser Leu Val Ser
        2195                2200                2205            
Ser Gln Arg Pro Leu Asp Arg Pro Pro Ala Val Ala Gly Pro Arg Pro
    2210                2215                2220                
Gln Leu Ser Asp Lys Pro Ser Pro Val Thr Ser Pro Ser Ser Ser Pro
2225                2230                2235                2240
Ser Val Arg Ser Gln Pro Leu Glu Ser Pro Leu Gly Thr Ala Asp Pro
                2245                2250                2255    
Arg Leu Asp Lys Ser Ile Gly Ala Ala Ser Pro Arg Pro Gln Ser Leu
            2260                2265                2270        
Glu Lys Thr Ser Val Pro Thr Gly Leu Arg Leu Pro Pro Pro Asp Arg
        2275                2280                2285            
Leu Leu Ile Thr Ser Ser Pro Lys Pro Gln Thr Ser Asp Arg Pro Thr
    2290                2295                2300                
Asp Lys Pro His Ala Ser Leu Ser Gln Arg Leu Pro Pro Pro Glu Lys
2305                2310                2315                2320
Val Leu Ser Ala Val Val Gln Thr Leu Val Ala Lys Glu Lys Ala Leu
                2325                2330                2335    
Arg Pro Val Asp Gln Asn Thr Gln Ser Lys Asn Arg Ala Ala Leu Val
            2340                2345                2350        
Met Asp Leu Ile Asp Leu Thr Pro Arg Gln Lys Glu Arg Ala Ala Ser
        2355                2360                2365            
Pro His Gln Val Thr Pro Gln Ala Asp Glu Lys Met Pro Val Leu Glu
    2370                2375                2380                
Ser Ser Ser Trp Pro Ala Ser Lys Gly Leu Gly His Met Pro Arg Ala
2385                2390                2395                2400
Val Glu Lys Gly Cys Val Ser Asp Pro Leu Gln Thr Ser Gly Lys Ala
                2405                2410                2415    
Ala Ala Pro Ser Glu Asp Pro Trp Gln Ala Val Lys Ser Leu Thr Gln
            2420                2425                2430        
Ala Arg Leu Ser Ser Gln Pro Ser Ala Lys Ala Phe Leu Tyr Glu Pro
        2435                2440                2445            
Thr Thr Gln Ala Ser Gly Arg Ala Ser Ala Gly Ala Glu Gln Thr Gln
    2450                2455                2460                
Gly Phe Phe Thr Lys Ser Pro Ala Leu Val Glu Asn Lys Gly Lys Thr
2465                2470                2475                2480
Lys Trp Val Gly Arg Pro Thr Asn Tyr Leu His Leu Ala Ala Lys Ser
                2485                2490                2495    
Trp Gln Ser Phe Arg Ser Leu Gly Lys Ala Pro Pro Ser Ser Pro Asn
            2500                2505                2510        
Glu Glu Lys Lys Leu Val Thr Thr Glu Gln Ser Pro Trp Ala Leu Gly
        2515                2520                2525            
Lys Ala Ser Ser Arg Ala Gly Leu Trp Pro Ile Val Ala Gly Gln Thr
    2530                2535                2540                
Leu Ala Gln Ser Cys Trp Ser Ala Gly Ser Thr Gln Thr Leu Ala Gln
2545                2550                2555                2560
Thr Cys Trp Ser Leu Gly Arg Gly Gln Asp Pro Lys Pro Glu Gln Asn
                2565                2570                2575    
Thr Leu Pro Ala Leu Asn Gln Ala Pro Ser Ser His Lys Cys Ala Glu
            2580                2585                2590        
Ser Glu Gln Lys
        2595    


<210> 2313
<211> 677
<212> PRT
<213> Homo sapiens

<400> 2313
Asp Met Ser Asn Ile Asp Leu Val Glu Gly Asp Glu Gly Arg Met Cys
 1               5                  10                  15      
Ile Asn Thr Glu Trp Gly Ala Phe Gly Asp Asp Gly Ala Leu Glu Asp
            20                  25                  30          
Ile Arg Thr Glu Phe Asp Arg Glu Leu Asp Leu Gly Ser Leu Asn Pro
        35                  40                  45              
Gly Lys Gln Leu Phe Glu Lys Met Ile Ser Gly Leu Tyr Leu Gly Glu
    50                  55                  60                  
Leu Val Arg Leu Ile Leu Leu Lys Met Ala Lys Ala Gly Leu Leu Phe
65                  70                  75                  80  
Gly Gly Glu Lys Ser Ser Ala Leu His Thr Lys Gly Lys Ile Glu Thr
                85                  90                  95      
Arg His Val Ala Ala Met Glu Lys Tyr Lys Glu Gly Leu Ala Asn Thr
            100                 105                 110         
Arg Glu Ile Leu Val Asp Leu Gly Leu Glu Pro Ser Glu Ala Asp Cys
        115                 120                 125             
Ile Ala Val Gln His Val Cys Thr Ile Val Ser Phe Arg Ser Ala Asn
    130                 135                 140                 
Leu Cys Ala Ala Ala Leu Ala Ala Ile Leu Thr Arg Leu Arg Glu Asn
145                 150                 155                 160 
Lys Lys Val Glu Arg Leu Arg Thr Thr Val Gly Met Asp Gly Thr Leu
                165                 170                 175     
Tyr Lys Ile His Pro Gln Tyr Pro Lys Arg Leu His Lys Val Val Arg
            180                 185                 190         
Lys Leu Val Pro Ser Cys Asp Val Arg Phe Leu Leu Ser Glu Ser Gly
        195                 200                 205             
Ser Thr Lys Gly Ala Ala Met Val Thr Ala Val Ala Ser Arg Val Gln
    210                 215                 220                 
Ala Gln Arg Lys Gln Ile Asp Arg Val Leu Ala Leu Phe Gln Leu Thr
225                 230                 235                 240 
Arg Glu Gln Leu Val Asp Val Gln Ala Lys Met Arg Ala Glu Leu Glu
                245                 250                 255     
Tyr Gly Leu Lys Lys Lys Ser His Gly Leu Ala Thr Val Arg Met Leu
            260                 265                 270         
Pro Thr Tyr Val Cys Gly Leu Pro Asp Gly Thr Glu Lys Gly Lys Phe
        275                 280                 285             
Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val Leu Leu Val Lys
    290                 295                 300                 
Ile Arg Ser Gly Arg Arg Ser Val Arg Met Tyr Asn Lys Ile Phe Ala
305                 310                 315                 320 
Ile Pro Leu Glu Ile Met Gln Gly Thr Gly Glu Glu Leu Phe Asp His
                325                 330                 335     
Ile Val Gln Cys Ile Ala Asp Phe Leu Asp Tyr Met Gly Leu Lys Gly
            340                 345                 350         
Ala Ser Leu Pro Leu Gly Phe Thr Phe Ser Phe Pro Cys Arg Gln Met
        355                 360                 365             
Ser Ile Asp Lys Gly Thr Leu Ile Gly Trp Thr Lys Gly Phe Lys Ala
    370                 375                 380                 
Thr Asp Cys Glu Gly Glu Asp Val Val Asp Met Leu Arg Glu Ala Ile
385                 390                 395                 400 
Lys Arg Arg Asn Glu Phe Asp Leu Asp Ile Val Ala Val Val Asn Asp
                405                 410                 415     
Thr Val Gly Thr Met Met Thr Cys Gly Tyr Glu Asp Pro Asn Cys Glu
            420                 425                 430         
Ile Gly Leu Ile Ala Gly Thr Gly Ser Asn Met Cys Tyr Met Glu Asp
        435                 440                 445             
Met Arg Asn Ile Glu Met Val Glu Gly Gly Glu Gly Lys Met Cys Ile
    450                 455                 460                 
Asn Thr Glu Trp Gly Gly Phe Gly Asp Asn Gly Cys Ile Asp Asp Ile
465                 470                 475                 480 
Arg Thr Arg Tyr Asp Thr Glu Val Asp Glu Gly Ser Leu Asn Pro Gly
                485                 490                 495     
Lys Gln Arg Tyr Glu Lys Met Thr Ser Gly Met Tyr Leu Gly Glu Ile
            500                 505                 510         
Val Arg Gln Ile Leu Ile Asp Leu Thr Lys Gln Gly Leu Leu Phe Arg
        515                 520                 525             
Gly Gln Ile Ser Glu Arg Leu Arg Thr Arg Gly Ile Phe Glu Thr Lys
    530                 535                 540                 
Phe Leu Ser Gln Ile Glu Ser Asp Arg Leu Ala Leu Leu Gln Val Arg
545                 550                 555                 560 
Arg Ile Leu Gln Gln Leu Gly Leu Asp Ser Thr Cys Glu Asp Ser Ile
                565                 570                 575     
Val Val Lys Glu Val Cys Gly Ala Val Ser Arg Arg Ala Ala Gln Leu
            580                 585                 590         
Cys Gly Ala Gly Leu Ala Ala Ile Val Glu Lys Arg Arg Glu Asp Gln
        595                 600                 605             
Gly Leu Glu His Leu Arg Ile Thr Val Gly Val Asp Gly Thr Leu Tyr
    610                 615                 620                 
Lys Leu His Pro His Phe Ser Arg Ile Leu Gln Glu Thr Val Lys Glu
625                 630                 635                 640 
Leu Ala Pro Arg Cys Asp Val Thr Phe Met Leu Ser Glu Asp Gly Ser
                645                 650                 655     
Gly Lys Gly Ala Ala Leu Ile Thr Ala Val Ala Lys Arg Leu Gln Gln
            660                 665                 670         
Ala Gln Lys Glu Asn
        675         


<210> 2314
<211> 558
<212> PRT
<213> Homo sapiens

<400> 2314
Pro Ala Leu Ala Ser Ala Ala Trp Ile Ser Arg Pro Gly Ser Gln Leu
 1               5                  10                  15      
Ser Asp Pro Thr Thr Arg Thr Leu Arg Pro Arg Met Glu Ala Pro Ala
            20                  25                  30          
Gln Lys Ala Gly Gln Gly Gly Leu Pro Lys Ala Asp Ala Gln Gly Ala
        35                  40                  45              
Ser Gly Ala Arg Glu Lys Arg Pro Glu Glu Pro Arg Pro Leu Glu Glu
    50                  55                  60                  
Asp Arg Ala Gly Ser Arg Pro Thr Gln Lys Gly Asp Leu Arg Gly Ala
65                  70                  75                  80  
Ala Gly Gly Arg Thr Thr Pro Pro Gly Gly Gly Ser Arg Gly Cys Ser
                85                  90                  95      
Leu Gly Val Ser Pro Gly Pro Gly Thr Arg His Ser Ala Gly Thr Arg
            100                 105                 110         
Pro Leu Val Arg Glu Pro Cys Gly Pro Thr Ser Ser Gln Asn Pro Glu
        115                 120                 125             
Leu Val Ile Pro Glu Gly Leu Gln Ala Arg Glu Gly Pro Cys Arg Ser
    130                 135                 140                 
Pro Ala Arg Gly Gly Asp Cys Ser Arg Asn Ser Cys Leu Ala Trp His
145                 150                 155                 160 
Arg Gly Ala Pro Ala Gly Glu Thr Pro Pro Val Cys Asp Pro Cys Pro
                165                 170                 175     
Glu Arg Ile Gln Asn His Pro Arg Thr Gln Leu Cys Glu Val His Thr
            180                 185                 190         
Asp Cys Trp Pro Cys Gln Pro Gly Thr Gly Ala Pro Thr Cys Pro Arg
        195                 200                 205             
Thr Pro Lys Pro Thr Ser Arg Gly Arg Asn Pro Leu Val Glu Gln Pro
    210                 215                 220                 
Arg Ala Cys Ala Cys Gly Glu Ala Phe Ala Trp Arg Ala Leu Arg Ile
225                 230                 235                 240 
Pro Gln Glu Arg Leu Gln Ala Thr Glu Glu Pro Arg Pro Cys Ala Arg
                245                 250                 255     
Cys Gly Lys Arg Phe Arg Pro Asn Gln Gln Gln Gln Ala Gly Lys Ser
            260                 265                 270         
Pro Pro Val Cys Pro Glu Cys Gly Gln Thr Ser Arg Pro Arg Pro Ile
        275                 280                 285             
Val Pro Asp Pro Pro Ala Gln Arg Leu Tyr Ala Cys Asp Glu Cys Gly
    290                 295                 300                 
Lys Ala Phe Thr Arg Thr Ser Ser Leu Leu Gln His Gln Arg Ile His
305                 310                 315                 320 
Thr Gly Glu Arg Pro Tyr Glu Cys Ala Glu Cys Gly Lys Ala Phe Val
                325                 330                 335     
Arg Cys Ser Gly Leu Tyr Arg His Gln Lys Thr His Ser Ala Glu Arg
            340                 345                 350         
His Arg Arg Gly Pro Val Leu Ala Arg Arg Ala Phe Arg Leu Gly Cys
        355                 360                 365             
Pro Pro Cys Gly Asp Tyr Ser Glu Arg Ser Pro Arg Arg Gly Ser Gly
    370                 375                 380                 
Ala Gly Glu Lys Pro Tyr Glu Cys Ala Asp Cys Ala Lys Ala Phe Gly
385                 390                 395                 400 
Leu Phe Ser His Leu Val Glu His Arg Arg Val His Thr Gly Glu Lys
                405                 410                 415     
Pro Tyr Ala Cys Pro Glu Cys Gly Lys Ala Phe Asn Gln Arg Ser Asn
            420                 425                 430         
Leu Ser Arg His Gln Arg Thr His Ser Ser Ala Lys Pro Tyr Ala Cys
        435                 440                 445             
Pro Leu Cys Glu Lys Ala Phe Lys Gly Arg Ser Gly Leu Val Gln His
    450                 455                 460                 
Gln Arg Ala His Thr Gly Glu Arg Pro Tyr Gly Cys Ser Glu Cys Gly
465                 470                 475                 480 
Lys Thr Phe Arg Gly Cys Ser Glu Leu Arg Gln His Glu Arg Leu His
                485                 490                 495     
Ser Gly Glu Lys Pro Tyr Ile Cys Arg Asp Cys Gly Lys Ala Phe Val
            500                 505                 510         
Arg Asn Cys Ser Leu Val Arg His Leu Arg Thr His Thr Gly Glu Arg
        515                 520                 525             
Pro Tyr Ala Cys Gly Asp Cys Gly Arg Ala Phe Ser Gln Arg Ser Asn
    530                 535                 540                 
Leu Asn Glu His Arg Lys Arg His Gly Gly Arg Ala Ala Pro
545                 550                 555             


<210> 2315
<211> 277
<212> PRT
<213> Homo sapiens

<400> 2315
Met Ala Glu Asp Trp Leu Asp Cys Pro Ala Leu Gly Pro Gly Trp Lys
 1               5                  10                  15      
Arg Arg Glu Val Phe Arg Lys Ser Gly Ala Thr Cys Gly Arg Ser Asp
            20                  25                  30          
Thr Tyr Tyr Gln Ser Pro Thr Gly Asp Arg Ile Arg Ser Lys Val Glu
        35                  40                  45              
Leu Thr Arg Tyr Leu Gly Pro Ala Cys Asp Leu Thr Leu Phe Asp Phe
    50                  55                  60                  
Lys Gln Gly Ile Leu Cys Tyr Pro Ala Pro Lys Ala His Pro Val Ala
65                  70                  75                  80  
Val Ala Ser Lys Lys Arg Lys Lys Pro Ser Arg Pro Ala Lys Thr Arg
                85                  90                  95      
Lys Arg Gln Val Gly Pro Gln Ser Gly Glu Val Arg Lys Glu Ala Pro
            100                 105                 110         
Arg Asp Glu Thr Lys Ala Asp Thr Asp Thr Ala Pro Ala Ser Phe Pro
        115                 120                 125             
Ala Pro Gly Cys Cys Glu Asn Cys Gly Ile Ser Phe Ser Gly Asp Gly
    130                 135                 140                 
Thr Gln Arg Gln Arg Leu Lys Thr Leu Cys Lys Asp Cys Arg Ala Gln
145                 150                 155                 160 
Arg Ile Ala Phe Asn Arg Glu Gln Arg Met Phe Lys Ser Arg Gly Cys
                165                 170                 175     
Gly Val Cys Arg Gly Cys Gln Thr Gln Glu Asp Cys Gly His Cys Pro
            180                 185                 190         
Ile Cys Leu Arg Pro Pro Arg Pro Gly Leu Arg Arg Gln Trp Lys Cys
        195                 200                 205             
Val Gln Arg Leu Met Asn Tyr Ser Leu Pro Ala Phe Ser Asn Asn Ile
    210                 215                 220                 
Thr Gly Arg Glu Glu Arg Lys Val Gly Val Lys Asp Pro Val Ile Cys
225                 230                 235                 240 
Phe His Leu Lys Cys Pro Ile Ser Arg Ala Ser Trp Arg Lys Pro Val
                245                 250                 255     
Val Pro Ala Thr Arg Glu Ala Gly Ala Gly Glu Ser Leu Glu Pro Arg
            260                 265                 270         
Ser Trp Arg Pro Gln
        275         


<210> 2316
<211> 895
<212> PRT
<213> Homo sapiens

<400> 2316
Met Arg Met Ser Val Gly Leu Ser Leu Leu Leu Pro Leu Trp Gly Arg
 1               5                  10                  15      
Thr Phe Leu Leu Leu Leu Ser Val Val Met Ala Gln Ser His Trp Pro
            20                  25                  30          
Ser Glu Pro Ser Glu Ala Val Arg Asp Trp Glu Asn Gln Leu Glu Ala
        35                  40                  45              
Ser Met His Ser Val Leu Ser Asp Leu His Glu Ala Val Pro Thr Val
    50                  55                  60                  
Val Gly Ile Pro Asp Gly Thr Ala Val Val Gly Arg Ser Phe Arg Val
65                  70                  75                  80  
Thr Ile Pro Thr Asp Leu Ile Ala Ser Ser Gly Asp Ile Ile Lys Val
                85                  90                  95      
Ser Ala Ala Gly Lys Glu Ala Leu Pro Ser Trp Leu His Trp Asp Ser
            100                 105                 110         
Gln Ser His Thr Leu Glu Gly Leu Pro Leu Asp Thr Asp Lys Gly Val
        115                 120                 125             
His Tyr Ile Ser Val Ser Ala Thr Arg Leu Gly Ala Asn Gly Ser His
    130                 135                 140                 
Ile Pro Gln Thr Ser Ser Val Phe Ser Ile Glu Val Tyr Pro Glu Asp
145                 150                 155                 160 
His Ser Glu Leu Gln Ser Val Arg Thr Ala Ser Pro Asp Pro Gly Glu
                165                 170                 175     
Val Val Ser Ser Ala Cys Ala Ala Asp Glu Pro Val Thr Val Leu Thr
            180                 185                 190         
Val Ile Leu Asp Ala Asp Leu Thr Lys Met Thr Pro Lys Gln Arg Ile
        195                 200                 205             
Asp Leu Leu His Arg Met Arg Ser Phe Ser Glu Val Glu Leu His Asn
    210                 215                 220                 
Met Lys Leu Val Pro Val Val Asn Asn Arg Leu Phe Asp Met Ser Ala
225                 230                 235                 240 
Phe Met Ala Gly Pro Gly Asn Ala Lys Lys Val Val Glu Asn Gly Ala
                245                 250                 255     
Leu Leu Ser Trp Lys Leu Gly Cys Ser Leu Asn Gln Asn Ser Val Pro
            260                 265                 270         
Asp Ile His Gly Val Glu Ala Pro Ala Arg Glu Gly Ala Met Ser Ala
        275                 280                 285             
Gln Leu Gly Tyr Pro Val Val Gly Trp His Ile Ala Asn Lys Lys Pro
    290                 295                 300                 
Pro Leu Pro Lys Arg Val Arg Arg Gln Ile His Ala Thr Pro Thr Pro
305                 310                 315                 320 
Val Thr Ala Ile Gly Pro Pro Thr Thr Ala Ile Gln Glu Pro Pro Ser
                325                 330                 335     
Arg Ile Val Pro Thr Pro Thr Ser Pro Ala Ile Ala Pro Pro Thr Glu
            340                 345                 350         
Thr Met Ala Pro Pro Val Arg Asp Pro Val Pro Gly Lys Pro Thr Val
        355                 360                 365             
Thr Ile Arg Thr Arg Gly Ala Ile Ile Gln Thr Pro Thr Leu Gly Pro
    370                 375                 380                 
Ile Gln Pro Thr Arg Val Ser Glu Ala Gly Thr Thr Val Pro Gly Gln
385                 390                 395                 400 
Ile Arg Pro Thr Met Thr Ile Pro Gly Tyr Val Glu Pro Thr Ala Val
                405                 410                 415     
Ala Thr Pro Pro Thr Thr Thr Thr Lys Lys Pro Arg Val Ser Thr Pro
            420                 425                 430         
Lys Pro Ala Thr Pro Ser Thr Asp Ser Thr Thr Thr Thr Thr Arg Arg
        435                 440                 445             
Pro Thr Lys Lys Pro Arg Thr Pro Arg Pro Val Pro Arg Val Thr Thr
    450                 455                 460                 
Lys Val Ser Ile Thr Arg Leu Glu Thr Ala Ser Pro Pro Thr Arg Ile
465                 470                 475                 480 
Arg Thr Thr Thr Ser Gly Val Pro Arg Gly Gly Glu Pro Asn Gln Arg
                485                 490                 495     
Pro Glu Leu Lys Asn His Ile Asp Arg Val Asp Ala Trp Val Gly Thr
            500                 505                 510         
Tyr Phe Glu Val Lys Ile Pro Ser Asp Thr Phe Tyr Asp His Glu Asp
        515                 520                 525             
Thr Thr Thr Asp Lys Leu Lys Leu Thr Leu Lys Leu Arg Glu Gln Gln
    530                 535                 540                 
Leu Val Gly Glu Lys Ser Trp Val Gln Phe Asn Ser Asn Ser Gln Leu
545                 550                 555                 560 
Met Tyr Gly Leu Pro Asp Ser Ser His Val Gly Lys His Glu Tyr Phe
                565                 570                 575     
Met His Ala Thr Asp Lys Gly Gly Leu Ser Ala Val Asp Ala Phe Glu
            580                 585                 590         
Ile His Val His Arg Arg Pro Gln Gly Asp Arg Ala Pro Ala Arg Phe
        595                 600                 605             
Lys Ala Lys Phe Val Gly Asp Pro Ala Leu Val Leu Asn Asp Ile His
    610                 615                 620                 
Lys Lys Ile Ala Leu Val Lys Lys Leu Ala Phe Ala Phe Gly Asp Arg
625                 630                 635                 640 
Asn Cys Ser Thr Ile Thr Leu Gln Asn Ile Thr Arg Gly Ser Ile Val
                645                 650                 655     
Val Glu Trp Thr Asn Asn Thr Leu Pro Leu Glu Pro Cys Pro Lys Glu
            660                 665                 670         
Gln Ile Ala Gly Leu Ser Arg Arg Ile Ala Glu Asp Asp Gly Lys Pro
        675                 680                 685             
Arg Pro Ala Phe Ser Asn Ala Leu Glu Pro Asp Phe Lys Ala Thr Ser
    690                 695                 700                 
Ile Thr Val Thr Gly Ser Gly Ser Cys Arg His Leu Gln Phe Ile Pro
705                 710                 715                 720 
Val Val Pro Pro Arg Arg Val Pro Ser Glu Ala Pro Pro Thr Glu Val
                725                 730                 735     
Pro Asp Arg Asp Pro Glu Lys Ser Ser Glu Asp Asp Val Tyr Leu His
            740                 745                 750         
Thr Val Ile Pro Ala Val Val Val Ala Ala Ile Leu Leu Ile Ala Gly
        755                 760                 765             
Ile Ile Ala Met Ile Cys Tyr Arg Lys Lys Arg Lys Gly Lys Leu Thr
    770                 775                 780                 
Leu Glu Asp Gln Ala Thr Phe Ile Lys Lys Gly Val Pro Ile Ile Phe
785                 790                 795                 800 
Ala Asp Glu Leu Asp Asp Ser Lys Pro Pro Pro Ser Ser Ser Met Pro
                805                 810                 815     
Leu Ile Leu Gln Glu Glu Lys Ala Pro Leu Pro Pro Pro Glu Tyr Pro
            820                 825                 830         
Asn Gln Ser Val Pro Glu Thr Thr Pro Leu Asn Gln Asp Thr Met Gly
        835                 840                 845             
Glu Tyr Thr Pro Leu Arg Asp Glu Asp Pro Asn Ala Pro Pro Tyr Gln
    850                 855                 860                 
Pro Pro Pro Pro Phe Thr Ala Pro Met Glu Gly Lys Gly Ser Arg Pro
865                 870                 875                 880 
Lys Asn Met Thr Pro Tyr Arg Ser Pro Pro Pro Tyr Val Pro Pro
                885                 890                 895 


<210> 2317
<211> 2021
<212> PRT
<213> Homo sapiens

<400> 2317
Met Ser Thr Glu Asp Glu Lys Leu Leu Lys Glu Ala Lys Lys Leu Pro
 1               5                  10                  15      
Trp Glu Asp Arg Leu Gly His Lys Asn Trp Lys Val Arg Asn Glu Ala
            20                  25                  30          
Asn Val Asp Leu Ala Ser Val Phe Asp Ser Ile Thr Asp Pro Lys Asp
        35                  40                  45              
Pro Arg Leu Arg Asp Phe Gly His Leu Phe Arg Lys Thr Val Ala Asp
    50                  55                  60                  
Ser Asn Ala Pro Val Gln Glu Lys Ala Leu Asp Ala Leu Ile Ala Phe
65                  70                  75                  80  
Leu Arg Ala Ala Asp Ser Asp Ala Gly Arg Tyr Ala Lys Glu Val Cys
                85                  90                  95      
Asp Ala Ile Ala Leu Lys Cys Leu Thr Gly Arg Lys Asn Thr Val Asp
            100                 105                 110         
Lys Ala Gln Ala Ala Phe Leu Leu Trp Val Glu Leu Glu Ala Val Asp
        115                 120                 125             
Val Phe Leu Asp Thr Met Glu Lys Ala Ile Lys Asn Lys Val Ala Lys
    130                 135                 140                 
Ala Val Val Pro Ala Val Asp Val Met Phe Gln Ala Leu Ser Glu Phe
145                 150                 155                 160 
Gly Ser Lys Val Ile Pro Pro Lys Arg Ile Leu Lys Met Leu Pro Glu
                165                 170                 175     
Leu Phe Asp His Gln Asp Gln Asn Val Arg Ala Ser Ala Lys Gly Val
            180                 185                 190         
Thr Leu Glu Leu Cys Arg Trp Ile Gly Lys Asp Pro Val Lys Ser Ile
        195                 200                 205             
Leu Phe Glu Lys Met Arg Asp Thr Met Lys Lys Glu Leu Glu Ala Glu
    210                 215                 220                 
Leu Ala Asn Val Thr Ala Gly Ala Lys Pro Thr Arg Lys Ile Arg Ser
225                 230                 235                 240 
Glu Gln Asp Lys Glu Pro Glu Ala Glu Ala Ser Ser Asp Val Val Gly
                245                 250                 255     
Asp Gly Pro Ser Glu Glu Ala Val Ala Asp Ala Pro Gln Glu Ile Asp
            260                 265                 270         
Glu Tyr Asp Leu Met Asp Pro Val Asp Ile Leu Thr Pro Leu Glu Lys
        275                 280                 285             
Ser Gly Phe Trp Asp Gly Val Lys Ala Thr Lys Trp Ser Glu Arg Lys
    290                 295                 300                 
Glu Ala Val Ala Glu Leu Thr Lys Leu Ala Ser Thr Lys Lys Ile Ala
305                 310                 315                 320 
Pro Gly Asp Phe Ser Glu Ile Cys Arg Thr Leu Lys Lys Leu Ile Thr
                325                 330                 335     
Asp Val Asn Leu Ala Val Ala Val Glu Ala Ile Gln Ala Ile Gly Asn
            340                 345                 350         
Leu Ala Cys Gly Leu Arg Thr His Phe Ser Ala Ser Ser Arg Phe Met
        355                 360                 365             
Leu Pro Val Leu Leu Glu Lys Leu Lys Glu Lys Lys Gln Ser Val Thr
    370                 375                 380                 
Asp Pro Leu Thr Gln Thr Leu Gln Thr Met Tyr Lys Ala Gly Cys Leu
385                 390                 395                 400 
Asn Leu Val Asp Val Ile Glu Gly Lys Asn Val Lys Thr Ala Val Lys
                405                 410                 415     
Asn Lys Val Pro Leu Val Arg Ser Ser Thr Leu Thr Trp Leu Thr Phe
            420                 425                 430         
Cys Leu Glu Thr Ser Asn Lys Ala Leu Ile Leu Lys Ala His Lys Glu
        435                 440                 445             
Tyr Val Pro Leu Cys Met Glu Cys Leu Asn Asp Gly Thr Pro Asp Val
    450                 455                 460                 
Arg Asp Ala Ala Phe Ser Ala Leu Ala Ala Ile Ala Lys Ser Val Gly
465                 470                 475                 480 
Met Arg Pro Leu Glu Arg Ser Leu Glu Lys Leu Asp Asp Val Arg Lys
                485                 490                 495     
Lys Lys Leu Ser Glu Met Ile Ala Gly Ser Gly Gly Gly Asp Gln Ala
            500                 505                 510         
Gly Thr Ser Ser Val Thr Val Gln Ser Ser Val Gly Ser Thr Ala Thr
        515                 520                 525             
Gly Cys Leu His Asn Arg Tyr Thr Thr Ser Lys Phe Met Gln Asn Ser
    530                 535                 540                 
Asp Ala Ser Phe Val Arg Lys Ser Ala Ala Ser Met Leu Ser Gly Lys
545                 550                 555                 560 
Arg Pro Ala Pro Ser Ala Gln Ala Ser Lys Lys Val Gly Thr Gly Lys
                565                 570                 575     
Pro Gly Gly Gly Lys Lys Asp Gly Ser Val Arg Asn Glu Gly Ser Lys
            580                 585                 590         
Ser Val Glu Pro Pro Glu Asp Val Glu Pro Ala Glu Met Gly Leu Glu
        595                 600                 605             
Glu Ile Glu Asn Arg Leu Gly Ser Leu Val Lys Pro Glu Thr Val Ser
    610                 615                 620                 
Gln Leu Lys Ser Ser Val Trp Lys Glu Arg Leu Glu Ala Thr Leu Ala
625                 630                 635                 640 
Leu Lys Glu Glu Ile Glu Gly Leu Gln Glu Leu Asp Lys Ser Val Glu
                645                 650                 655     
Ile Leu Val Arg Leu Leu Cys Ala Val Pro Gly Trp Asn Glu Lys Asn
            660                 665                 670         
Val Gln Leu Phe Ser Phe Glu Asn Tyr Phe Phe Ser Asn Leu Pro Asp
        675                 680                 685             
Phe Ser Ile Asn Ser Leu Gly Thr Ser Glu Arg Val Ala Asp Ile Lys
    690                 695                 700                 
Thr Arg Ala Ser Ala Met Lys Cys Leu Thr Ala Phe Cys Glu Ala Val
705                 710                 715                 720 
Gly Pro Gly Phe Val Phe Glu Arg Leu Phe Lys Ile Met Lys Glu His
                725                 730                 735     
Lys Asn Pro Lys Val Leu Ser Glu Gly Leu Leu Trp Met Val Ser Ala
            740                 745                 750         
Val Asp Asp Phe Gly Val Ser Leu Leu Lys Leu Lys Asp Leu Ile Asp
        755                 760                 765             
Phe Cys Lys Asp Val Gly Leu Gln Ser Ser Thr Ala Ala Thr Arg Asn
    770                 775                 780                 
Ala Thr Ile Lys Leu Leu Gly Ala Leu His Lys Phe Val Gly Pro Asp
785                 790                 795                 800 
Ile Lys Gly Phe Leu Asn Asp Val Lys Pro Ala Leu Leu Ser Ala Leu
                805                 810                 815     
Asp Thr Glu Tyr Glu Lys Asn Pro Phe Glu Gly Thr Ala Ala Pro Lys
            820                 825                 830         
Arg Val Val Lys Thr Ser Val Ser Thr Ser Thr Ser Ser Gly Gly Leu
        835                 840                 845             
Asp Ser Leu Pro Arg Glu Asp Ile Ser Thr Lys Ile Thr Pro Asn Leu
    850                 855                 860                 
Leu Lys Gly Phe Glu Ser Pro Asp Trp Lys Met Arg Leu Glu Ser Ile
865                 870                 875                 880 
Glu Ala Val Asn Lys Ile Leu Glu Glu Ala Asn Lys Arg Ile Gln Pro
                885                 890                 895     
Thr Gly Thr Gly Glu Leu Phe Gly Gly Leu Arg Gly Arg Leu Leu Asp
            900                 905                 910         
Ser Asn Lys Asn Leu Val Met Gln Thr Leu Thr Thr Ile Gly Gly Val
        915                 920                 925             
Ala Ala Ala Met Gly Pro Ala Val Glu Lys Ala Ser Lys Gly Ile Leu
    930                 935                 940                 
Ser Asp Val Leu Lys Cys Leu Gly Asp Asn Lys Lys His Met Arg Glu
945                 950                 955                 960 
Cys Thr Leu Ala Ala Leu Asp Leu Trp Leu Gly Ala Val His Leu Asp
                965                 970                 975     
Lys Met Ile Pro Tyr Ile Ile Ile Ala Leu Thr Asp Gly Lys Met Gly
            980                 985                 990         
Ala Glu Gly Arg Lys Asp Leu Phe Asp Trp Leu Thr Lys Gln Leu Thr
        995                 1000                1005            
Gly Leu Ser Asp Phe Val Asp Ala Ile His Leu Leu Lys Pro Ala Ser
    1010                1015                1020                
Thr Ala Met Thr Asp Lys Ser Ala Asp Val Arg Lys Ala Ala Glu Gly
1025                1030                1035                1040
Cys Ile Ser Glu Ile Leu Arg Val Ser Gly Gln Glu Met Ile Glu Lys
                1045                1050                1055    
Asn Leu Lys Asp Ile Gln Gly Pro Ala Leu Ala Leu Val Leu Glu Lys
            1060                1065                1070        
Val Arg Pro Gly Phe Val Gln Glu Pro Phe Glu Ser Ser Lys Ala Met
        1075                1080                1085            
Ala Gly Pro Val Ser Lys Gly Val Thr Lys Ile Ser Lys Ser Thr Ser
    1090                1095                1100                
Asn Gly Thr Leu Lys Gln Gly Asn Arg Ser Arg Ala Val Pro Thr Lys
1105                1110                1115                1120
Gly Ser Ser Gln Ile Thr Ser Val His Asp Ile Ala Ile Gln Ser Gln
                1125                1130                1135    
Ala Leu Leu Asn Thr Lys Asp Ser Asn Lys Glu Asp Arg Glu Arg Val
            1140                1145                1150        
Val Val Arg Arg Ile Lys Phe Glu Glu Leu Arg Pro Glu Gln Ile Gln
        1155                1160                1165            
Asp Leu Glu Asn Asp Met Met Lys Phe Phe Arg Glu Asp Leu Gln Lys
    1170                1175                1180                
Arg Leu Leu Ser Pro Asp Phe Lys Lys Gln Val Asp Gly Leu Glu Ile
1185                1190                1195                1200
Leu Gln Lys Ala Leu Pro Ser Val Ser Lys Glu Ile Ile Glu Val Leu
                1205                1210                1215    
Asp Val Leu Leu Arg Trp Phe Val Leu Gln Phe Cys Lys Ser Asn Thr
            1220                1225                1230        
Thr Cys Leu Leu Lys Val Leu Glu Phe Leu Pro Glu Leu Phe Asn Thr
        1235                1240                1245            
Leu Arg Asp Glu Glu Tyr Cys Met Thr Glu Ala Glu Ala Ala Ile Phe
    1250                1255                1260                
Leu Pro Cys Leu Ala Glu Lys Leu Gly His Asn Ile Glu Lys Val Arg
1265                1270                1275                1280
Glu Lys Met Arg Glu Leu Met Lys Gln Ile Ile Gln Ala Tyr Ser Val
                1285                1290                1295    
Gly Lys Thr Tyr Pro Tyr Ile Leu Glu Gly Leu Arg Ser Lys Asn Asn
            1300                1305                1310        
Arg Thr Arg Ile Glu Cys Thr Asp Leu Ile Gly Tyr Leu Leu Glu Thr
        1315                1320                1325            
Cys Gly Thr Glu Ile Gly Gly Leu Leu Lys Tyr Leu Asn Ile Val Ala
    1330                1335                1340                
Ser Leu Thr Ala Glu Arg Asp Gly Glu Leu Arg Lys Ala Ala Leu Asn
1345                1350                1355                1360
Thr Met Ala Thr Gly Tyr Gln Ile Leu Gly Ala Asp Ile Trp Lys Tyr
                1365                1370                1375    
Val Gly Lys Leu Thr Asp Ala Gln Lys Ser Met Ile Asp Asp Arg Phe
            1380                1385                1390        
Lys Trp Lys Val Ser Ser Lys Tyr Glu Pro Phe Phe Cys Phe Arg Leu
        1395                1400                1405            
Ala Lys Asp Met Glu Lys Arg Arg Glu Gly Lys Pro Gly Glu Ala Arg
    1410                1415                1420                
Ala Ala Leu Arg Arg Ser Val Arg Asp Ser Gly Cys Val Gly Ala Glu
1425                1430                1435                1440
Lys Glu Ser Met Met Gly Leu Val Ser Ile Ile Tyr Asp Phe Leu Phe
                1445                1450                1455    
Val Ser Arg Pro Glu Val Ala Glu Gln Ser Gly Asp Ile Ser Gln Thr
            1460                1465                1470        
Val Pro Gly Pro Leu Phe Pro Arg Gln Ser Tyr Gly Ile Ser Glu Gln
        1475                1480                1485            
Met Leu Glu Arg Thr Pro Val Pro Arg Thr Ile Ala Gly Val Asn Gly
    1490                1495                1500                
Pro Thr Asp Trp Asn Glu Ala Leu Asp Ile Ile Met Phe Gly Ser Pro
1505                1510                1515                1520
Glu Gln Ser Val Glu Gly Met Lys Val Val Cys His Glu Leu Ala Gln
                1525                1530                1535    
Ala Ser Asn Asp Pro Glu Glu Ser Ala Ile Asp Glu Leu Val Lys Asp
            1540                1545                1550        
Ala Asp Gly Leu Val Ser Cys Leu Ala Asn Lys Val Ala Lys Thr Phe
        1555                1560                1565            
Asp Val Ser Leu Met Gly Ala Ser Ser Arg Ser Cys Lys Tyr Val Leu
    1570                1575                1580                
Asn Thr Leu Met Gln Thr Phe Gln Asn Lys Lys Leu Ala His Ala Val
1585                1590                1595                1600
Lys Glu Gly Thr Leu Glu Ser Leu Ile Thr Glu Leu Leu Leu Trp Leu
                1605                1610                1615    
Leu Asp Glu Arg Val Pro Arg Met Glu Asp Gly Ser Gln Leu Leu Lys
            1620                1625                1630        
Ala Leu Asn Val Leu Met Leu Lys Ile Leu Asp Asn Ala Asp Arg Thr
        1635                1640                1645            
Ser Ser Phe Val Val Leu Ile Ser Leu Leu Arg Pro Leu Asp Pro Ser
    1650                1655                1660                
Arg Trp Pro Ser Pro Ala Thr Ala Glu Val Tyr Ala Val Arg Asn Gln
1665                1670                1675                1680
Lys Phe Ser Asp Leu Val Val Lys Cys Leu Ile Lys Leu Thr Lys Leu
                1685                1690                1695    
Leu Gln Ser Thr Ile Tyr Glu Val Asp Leu Asp Arg Leu Leu Gln Ser
            1700                1705                1710        
Ile His Val Tyr Leu Gln Asp Leu Gly Met Glu Glu Ile Arg Arg Arg
        1715                1720                1725            
Ala Gly Ala Asp Asp Lys Pro Leu Arg Met Val Lys Thr Val Leu His
    1730                1735                1740                
Glu Leu Val Lys Leu Arg Gly Ala Ala Ile Lys Gly His Leu Ser Leu
1745                1750                1755                1760
Val Pro Ile Asp Met Arg Pro Gln Pro Ile Ile Leu Ala Tyr Ile Asp
                1765                1770                1775    
Leu Asn Leu Glu Thr Leu Ala Ala Ala Arg Met Leu Thr Ala Thr Gly
            1780                1785                1790        
Pro Val Gly Gln Thr His Trp Thr Asp Ser Thr Ala Asn Asn Pro Ser
        1795                1800                1805            
Pro Pro Ala Asn Ser Ala Asp Val Gln Leu Lys Gln Glu Leu Gly Ala
    1810                1815                1820                
Ile Phe Lys Lys Ile Gly Asp Lys Gln Thr Ser Thr Ile Gly Leu Tyr
1825                1830                1835                1840
Asp Leu Tyr His Ile Thr Lys Ser Tyr Pro Lys Val Asp Ile Phe Ser
                1845                1850                1855    
Gln Leu Gln Asn Ala Ser Glu Ala Phe Arg Thr Tyr Ile Arg Asp Gly
            1860                1865                1870        
Leu Ala Gln Val Glu Lys Asn Ala Ala Ala Gly Arg Thr Pro Ser Ser
        1875                1880                1885            
Leu Pro Leu Ser Thr Pro Pro Pro Ser Ser Leu Ala Leu Pro Ser Pro
    1890                1895                1900                
Asp Ile Pro Ser Leu Ser Ser Leu Asp Val Lys Pro Leu Met Asn Pro
1905                1910                1915                1920
Arg Ser Asp Leu Tyr Thr Asp Asp Ile Arg Ala Ser Asn Met Asn Pro
                1925                1930                1935    
Gly Val Met Thr Gly Thr Leu Asp Ala Ile Arg Glu Arg Met Lys Asn
            1940                1945                1950        
Met Gln Leu Ala Ser Ser Glu Pro Val Ser Lys Pro Leu Met Pro Thr
        1955                1960                1965            
Asn Asp Asn Leu Ser Met Asn Gln Gln Ser Val Pro Pro Ser Gln Met
    1970                1975                1980                
Gly Gln Glu Thr Val His Thr His Pro Val Val Leu Pro Met Asp Glu
1985                1990                1995                2000
Lys Ala Leu Ser Gly Leu Gln Ala Arg Met Glu Arg Leu Lys Gly Gly
                2005                2010                2015    
Ser Leu Glu His Met
            2020    


<210> 2318
<211> 2090
<212> PRT
<213> Homo sapiens

<400> 2318
Met Glu Asp Thr Gln Ala Ile Asp Trp Asp Val Glu Glu Glu Glu Glu
 1               5                  10                  15      
Thr Glu Gln Ser Ser Glu Ser Leu Arg Cys Asn Val Glu Pro Val Gly
            20                  25                  30          
Arg Leu His Ile Phe Ser Gly Ala His Gly Pro Glu Lys Asp Phe Pro
        35                  40                  45              
Leu His Leu Gly Lys Asn Val Val Gly Arg Met Pro Asp Cys Ser Val
    50                  55                  60                  
Ala Leu Pro Phe Pro Ser Ile Ser Lys Gln His Ala Glu Ile Glu Ile
65                  70                  75                  80  
Leu Ala Trp Asp Lys Ala Pro Ile Leu Arg Asp Cys Gly Ser Leu Asn
                85                  90                  95      
Gly Thr Gln Ile Leu Arg Pro Pro Lys Val Leu Ser Pro Gly Val Ser
            100                 105                 110         
His Arg Leu Arg Asp Gln Glu Leu Ile Leu Phe Ala Asp Leu Leu Cys
        115                 120                 125             
Gln Tyr His Arg Leu Asp Val Ser Leu Pro Phe Val Ser Arg Gly Pro
    130                 135                 140                 
Leu Thr Val Glu Glu Thr Pro Arg Val Gln Gly Glu Thr Gln Pro Gln
145                 150                 155                 160 
Arg Leu Leu Leu Ala Glu Asp Ser Glu Glu Glu Val Asp Phe Leu Ser
                165                 170                 175     
Glu Arg Arg Met Val Lys Lys Ser Arg Thr Thr Ser Ser Ser Val Ile
            180                 185                 190         
Val Pro Glu Ser Asp Glu Glu Gly His Ser Pro Val Leu Gly Gly Leu
        195                 200                 205             
Gly Pro Pro Phe Ala Phe Asn Leu Asn Ser Asp Thr Asp Val Glu Glu
    210                 215                 220                 
Gly Gln Gln Pro Ala Thr Glu Glu Ala Ser Ser Ala Ala Arg Arg Gly
225                 230                 235                 240 
Ala Thr Val Glu Ala Lys Gln Ser Glu Ala Lys Val Val Thr Glu Ile
                245                 250                 255     
Gln Leu Glu Lys Asp Gln Pro Leu Val Lys Glu Arg Asp Asn Asp Thr
            260                 265                 270         
Lys Val Lys Arg Gly Ala Gly Asn Gly Val Val Pro Ala Gly Val Ile
        275                 280                 285             
Leu Glu Arg Ser Gln Pro Pro Gly Glu Asp Ser Asp Thr Asp Val Asp
    290                 295                 300                 
Asp Asp Ser Arg Pro Pro Gly Arg Pro Ala Glu Val His Leu Glu Arg
305                 310                 315                 320 
Ala Gln Pro Phe Gly Phe Ile Asp Ser Asp Thr Asp Ala Glu Glu Glu
                325                 330                 335     
Arg Ile Pro Ala Thr Pro Val Val Ile Pro Met Lys Lys Arg Lys Ile
            340                 345                 350         
Phe His Gly Val Gly Thr Arg Gly Pro Gly Ala Pro Gly Leu Ala His
        355                 360                 365             
Leu Gln Glu Ser Gln Ala Gly Ser Asp Thr Asp Val Glu Glu Gly Lys
    370                 375                 380                 
Ala Pro Gln Ala Val Pro Leu Glu Lys Ser Gln Ala Ser Met Val Ile
385                 390                 395                 400 
Asn Ser Asp Thr Asp Asp Glu Glu Glu Val Ser Ala Ala Leu Thr Leu
                405                 410                 415     
Ala His Leu Lys Glu Ser Gln Pro Ala Ile Trp Asn Arg Asp Ala Glu
            420                 425                 430         
Glu Asp Met Pro Gln Arg Val Val Leu Leu Gln Arg Ser Gln Thr Thr
        435                 440                 445             
Thr Glu Arg Asp Ser Asp Thr Asp Val Glu Glu Glu Glu Leu Pro Val
    450                 455                 460                 
Glu Asn Arg Glu Ala Val Leu Lys Asp His Thr Lys Ile Arg Ala Leu
465                 470                 475                 480 
Val Arg Ala His Ser Glu Lys Asp Gln Pro Pro Phe Gly Asp Ser Asp
                485                 490                 495     
Asp Ser Val Glu Ala Asp Lys Ser Ser Pro Gly Ile His Leu Glu Arg
            500                 505                 510         
Ser Gln Ala Ser Thr Thr Val Asp Ile Asn Thr Gln Val Glu Lys Glu
        515                 520                 525             
Val Pro Pro Gly Ser Ala Ile Ile His Ile Lys Lys His Gln Val Ser
    530                 535                 540                 
Val Glu Gly Thr Asn Gln Thr Asp Val Lys Ala Val Gly Gly Pro Ala
545                 550                 555                 560 
Lys Leu Leu Val Val Ser Leu Glu Glu Ala Trp Pro Leu His Gly Asp
                565                 570                 575     
Cys Glu Thr Asp Ala Glu Glu Gly Thr Ala Leu Thr Ala Ser Val Val
            580                 585                 590         
Ala Asp Val Arg Lys Ser Gln Leu Pro Ala Glu Gly Asp Ala Gly Ala
        595                 600                 605             
Glu Trp Ala Ala Ala Val Leu Lys Gln Glu Arg Ala His Glu Val Gly
    610                 615                 620                 
Ala Gln Gly Gly Pro Pro Val Ala Gln Val Glu Gln Asp Leu Pro Ile
625                 630                 635                 640 
Ser Arg Glu Asn Leu Thr Asp Leu Val Val Asp Thr Asp Thr Leu Gly
                645                 650                 655     
Glu Ser Thr Gln Pro Gln Arg Glu Gly Ala Gln Val Pro Thr Gly Arg
            660                 665                 670         
Glu Arg Glu Gln His Val Gly Gly Thr Lys Asp Ser Glu Asp Asn Tyr
        675                 680                 685             
Gly Asp Ser Glu Asp Leu Asp Leu Gln Ala Thr Gln Cys Phe Leu Glu
    690                 695                 700                 
Asn Gln Gly Leu Glu Ala Val Gln Ser Met Glu Asp Glu Pro Thr Gln
705                 710                 715                 720 
Ala Phe Met Leu Thr Pro Pro Gln Glu Leu Gly Pro Ser His Cys Ser
                725                 730                 735     
Phe Gln Thr Thr Gly Thr Leu Asp Glu Pro Trp Glu Val Leu Ala Thr
            740                 745                 750         
Gln Pro Phe Cys Leu Arg Glu Ser Glu Asp Ser Glu Thr Gln Pro Phe
        755                 760                 765             
Asp Thr His Leu Glu Ala Tyr Gly Pro Cys Leu Ser Pro Pro Arg Ala
    770                 775                 780                 
Ile Pro Gly Asp Gln His Pro Glu Ser Pro Val His Thr Glu Pro Met
785                 790                 795                 800 
Gly Ile Gln Gly Arg Gly Arg Gln Thr Val Asp Lys Val Met Gly Ile
                805                 810                 815     
Pro Lys Glu Thr Ala Glu Arg Val Gly Pro Glu Arg Gly Pro Leu Glu
            820                 825                 830         
Arg Glu Thr Glu Lys Leu Leu Pro Glu Arg Gln Thr Asp Val Thr Gly
        835                 840                 845             
Glu Glu Glu Leu Thr Lys Gly Lys Gln Asp Arg Glu Gln Lys Gln Leu
    850                 855                 860                 
Leu Ala Arg Asp Thr Gln Arg Gln Glu Ser Asp Lys Asn Gly Glu Ser
865                 870                 875                 880 
Ala Ser Pro Glu Arg Asp Arg Glu Ser Leu Lys Val Glu Ile Glu Thr
                885                 890                 895     
Ser Glu Glu Ile Gln Glu Lys Gln Val Gln Lys Gln Thr Leu Pro Ser
            900                 905                 910         
Lys Ala Phe Glu Arg Glu Val Glu Arg Pro Val Ala Asn Arg Glu Cys
        915                 920                 925             
Asp Pro Ala Glu Leu Glu Glu Lys Val Pro Lys Val Ile Leu Glu Arg
    930                 935                 940                 
Asp Thr Gln Arg Gly Glu Pro Glu Gly Gly Ser Gln Asp Gln Lys Gly
945                 950                 955                 960 
Gln Ala Ser Ser Pro Thr Pro Glu Pro Gly Val Gly Ala Gly Asp Leu
                965                 970                 975     
Pro Gly Pro Thr Ser Ala Pro Val Pro Ser Gly Ser Gln Ser Gly Gly
            980                 985                 990         
Arg Gly Ser Pro Val Ser Pro Arg Arg His Gln Lys Gly Ser Leu Leu
        995                 1000                1005            
Asn Cys Lys Met Pro Pro Ala Glu Lys Ala Ser Arg Ile Arg Ala Ala
    1010                1015                1020                
Glu Lys Val Ser Arg Gly Asp Gln Glu Ser Pro Asp Ala Cys Leu Pro
1025                1030                1035                1040
Pro Thr Val Pro Glu Ala Pro Ala Pro Pro Gln Lys Pro Leu Asn Ser
                1045                1050                1055    
Gln Ser Gln Lys His Leu Ala Pro Pro Pro Leu Leu Ser Pro Leu Leu
            1060                1065                1070        
Pro Ser Ile Lys Pro Thr Val Arg Lys Thr Arg Gln Asp Gly Ser Gln
        1075                1080                1085            
Glu Ala Pro Glu Ala Pro Leu Ser Ser Glu Leu Glu Pro Phe His Pro
    1090                1095                1100                
Lys Pro Lys Ile Arg Thr Arg Lys Ser Ser Arg Met Thr Pro Phe Pro
1105                1110                1115                1120
Ala Thr Ser Ala Ala Pro Glu Pro His Pro Ser Thr Ser Thr Ala Gln
                1125                1130                1135    
Pro Val Thr Pro Lys Pro Thr Ser Gln Ala Thr Arg Ser Arg Thr Asn
            1140                1145                1150        
Arg Ser Ser Val Lys Thr Pro Glu Pro Val Val Pro Thr Ala Pro Glu
        1155                1160                1165            
Leu Gln Pro Ser Thr Ser Thr Asp Gln Pro Val Thr Ser Glu Pro Thr
    1170                1175                1180                
Ser Gln Val Thr Arg Gly Arg Lys Ser Arg Ser Ser Val Lys Thr Pro
1185                1190                1195                1200
Glu Thr Val Val Pro Thr Ala Leu Glu Leu Gln Pro Ser Thr Ser Thr
                1205                1210                1215    
Asp Arg Pro Val Thr Ser Glu Pro Thr Ser Gln Ala Thr Arg Gly Arg
            1220                1225                1230        
Lys Asn Arg Ser Ser Val Lys Thr Pro Glu Pro Val Val Pro Thr Ala
        1235                1240                1245            
Pro Glu Leu Gln Pro Ser Thr Ser Thr Asp Gln Pro Val Thr Ser Glu
    1250                1255                1260                
Pro Thr Tyr Gln Ala Thr Arg Gly Arg Lys Asn Arg Ser Ser Val Lys
1265                1270                1275                1280
Thr Pro Glu Pro Val Val Pro Thr Ala Pro Glu Leu Arg Pro Ser Thr
                1285                1290                1295    
Ser Thr Asp Arg Pro Val Thr Pro Lys Pro Thr Ser Arg Thr Thr Arg
            1300                1305                1310        
Ser Arg Thr Asn Met Ser Ser Val Lys Thr Pro Glu Thr Val Val Pro
        1315                1320                1325            
Thr Ala Pro Glu Leu Gln Ile Ser Thr Ser Thr Asp Gln Pro Val Thr
    1330                1335                1340                
Pro Lys Pro Thr Ser Arg Thr Thr Arg Ser Arg Thr Asn Met Ser Ser
1345                1350                1355                1360
Val Lys Asn Pro Glu Ser Thr Val Pro Ile Ala Pro Glu Leu Pro Pro
                1365                1370                1375    
Ser Thr Ser Thr Glu Gln Pro Val Thr Pro Glu Pro Thr Ser Arg Ala
            1380                1385                1390        
Thr Arg Gly Arg Lys Asn Arg Ser Ser Gly Lys Thr Pro Glu Thr Leu
        1395                1400                1405            
Val Pro Thr Ala Pro Lys Leu Glu Pro Ser Thr Ser Thr Asp Gln Pro
    1410                1415                1420                
Val Thr Pro Glu Pro Thr Ser Gln Ala Thr Arg Gly Arg Thr Asn Arg
1425                1430                1435                1440
Ser Ser Val Lys Thr Pro Glu Thr Val Val Pro Thr Ala Pro Glu Leu
                1445                1450                1455    
Gln Pro Ser Thr Ser Thr Asp Gln Pro Val Thr Pro Glu Pro Thr Ser
            1460                1465                1470        
Gln Ala Thr Arg Gly Arg Thr Asp Arg Ser Ser Val Lys Thr Pro Glu
        1475                1480                1485            
Thr Val Val Pro Thr Ala Pro Glu Leu Gln Ala Ser Ala Ser Thr Asp
    1490                1495                1500                
Gln Pro Val Thr Ser Asp Pro Thr Ser Arg Thr Thr Arg Gly Arg Lys
1505                1510                1515                1520
Asn Arg Ser Ser Val Lys Thr Pro Glu Thr Val Val Pro Ala Ala Pro
                1525                1530                1535    
Glu Leu Gln Pro Pro Thr Ser Thr Asp Gln Pro Val Thr Pro Glu Pro
            1540                1545                1550        
Thr Ser Arg Ala Thr Arg Gly Arg Thr Asn Arg Ser Ser Val Lys Thr
        1555                1560                1565            
Pro Glu Ser Ile Val Pro Ile Ala Pro Glu Leu Gln Pro Ser Thr Ser
    1570                1575                1580                
Arg Asn Gln Leu Val Thr Pro Glu Pro Thr Ser Arg Ala Thr Arg Cys
1585                1590                1595                1600
Arg Thr Asn Arg Ser Ser Val Lys Thr Pro Glu Pro Val Val Pro Thr
                1605                1610                1615    
Ala Pro Glu Pro His Pro Thr Thr Ser Thr Asp Gln Pro Val Thr Pro
            1620                1625                1630        
Lys Leu Thr Ser Arg Ala Thr Arg Arg Lys Thr Asn Arg Ser Ser Val
        1635                1640                1645            
Lys Thr Pro Lys Pro Val Glu Pro Ala Ala Ser Asp Leu Glu Pro Phe
    1650                1655                1660                
Thr Pro Thr Asp Gln Ser Val Thr Pro Glu Ala Ile Ala Gln Gly Gly
1665                1670                1675                1680
Gln Ser Lys Thr Leu Arg Ser Ser Thr Val Arg Ala Met Pro Val Pro
                1685                1690                1695    
Thr Thr Pro Glu Phe Gln Ser Pro Val Thr Thr Asp Gln Pro Ile Ser
            1700                1705                1710        
Pro Glu Pro Ile Thr Gln Pro Ser Cys Ile Lys Arg Gln Arg Ala Ala
        1715                1720                1725            
Gly Asn Pro Gly Ser Leu Ala Ala Pro Ile Asp His Lys Pro Cys Ser
    1730                1735                1740                
Ala Pro Leu Glu Pro Lys Ser Gln Ala Ser Arg Asn Gln Arg Trp Gly
1745                1750                1755                1760
Ala Val Arg Ala Ala Glu Ser Leu Thr Ala Ile Pro Glu Pro Ala Ser
                1765                1770                1775    
Pro Gln Leu Leu Glu Thr Pro Ile His Ala Ser Gln Ile Gln Lys Val
            1780                1785                1790        
Glu Pro Ala Gly Arg Ser Arg Phe Thr Pro Glu Leu Gln Pro Lys Ala
        1795                1800                1805            
Ser Gln Ser Arg Lys Arg Ser Leu Ala Thr Met Asp Ser Pro Pro His
    1810                1815                1820                
Gln Lys Gln Pro Gln Arg Gly Glu Val Ser Gln Lys Thr Val Ile Ile
1825                1830                1835                1840
Lys Glu Glu Glu Glu Asp Thr Ala Glu Lys Pro Gly Lys Glu Glu Asp
                1845                1850                1855    
Val Val Thr Pro Lys Pro Gly Lys Arg Lys Arg Asp Gln Ala Glu Glu
            1860                1865                1870        
Glu Pro Asn Arg Ile Pro Ser Arg Ser Leu Arg Arg Thr Lys Leu Asn
        1875                1880                1885            
Gln Glu Ser Thr Ala Pro Lys Val Leu Phe Thr Gly Val Val Asp Ala
    1890                1895                1900                
Arg Gly Glu Arg Ala Val Leu Ala Leu Gly Gly Ser Leu Ala Gly Ser
1905                1910                1915                1920
Ala Ala Glu Ala Ser His Leu Val Thr Asp Arg Ile Arg Arg Thr Val
                1925                1930                1935    
Lys Phe Leu Cys Ala Leu Gly Arg Gly Ile Pro Ile Leu Ser Leu Asp
            1940                1945                1950        
Trp Leu His Gln Ser Arg Lys Ala Gly Phe Phe Leu Pro Pro Asp Glu
        1955                1960                1965            
Tyr Val Val Thr Asp Pro Glu Gln Glu Lys Asn Phe Gly Phe Ser Leu
    1970                1975                1980                
Gln Asp Ala Leu Ser Arg Ala Arg Glu Arg Arg Leu Leu Glu Gly Tyr
1985                1990                1995                2000
Glu Ile Tyr Val Thr Pro Gly Val Gln Pro Pro Pro Pro Gln Met Gly
                2005                2010                2015    
Glu Ile Ile Ser Cys Cys Gly Gly Thr Tyr Leu Pro Ser Met Pro Arg
            2020                2025                2030        
Ser Tyr Lys Pro Gln Arg Val Val Ile Thr Cys Pro Gln Asp Phe Pro
        2035                2040                2045            
His Cys Ser Ile Pro Leu Arg Val Gly Leu Pro Leu Leu Ser Pro Glu
    2050                2055                2060                
Phe Leu Leu Thr Gly Val Leu Lys Gln Glu Ala Lys Pro Glu Ala Phe
2065                2070                2075                2080
Val Leu Ser Pro Leu Glu Met Ser Ser Thr
                2085                2090


<210> 2319
<211> 1453
<212> PRT
<213> Homo sapiens

<400> 2319
Met Met Leu Pro Gln Asn Ser Trp His Ile Asp Phe Gly Arg Cys Cys
 1               5                  10                  15      
Cys His Gln Asn Leu Phe Ser Ala Val Val Thr Cys Ile Leu Leu Leu
            20                  25                  30          
Asn Ser Cys Phe Leu Ile Ser Ser Phe Asn Gly Thr Asp Leu Glu Leu
        35                  40                  45              
Arg Leu Val Asn Gly Asp Gly Pro Cys Ser Gly Thr Val Glu Val Lys
    50                  55                  60                  
Phe Gln Gly Gln Trp Gly Thr Val Cys Asp Asp Gly Trp Asn Thr Thr
65                  70                  75                  80  
Ala Ser Thr Val Val Cys Lys Gln Leu Gly Cys Pro Phe Ser Phe Ala
                85                  90                  95      
Met Phe Arg Phe Gly Gln Ala Val Thr Arg His Gly Lys Ile Trp Leu
            100                 105                 110         
Asp Asp Val Ser Cys Tyr Gly Asn Glu Ser Ala Leu Trp Glu Cys Gln
        115                 120                 125             
His Arg Glu Trp Gly Ser His Asn Cys Tyr His Gly Glu Asp Val Gly
    130                 135                 140                 
Val Asn Cys Tyr Gly Glu Ala Asn Leu Gly Leu Arg Leu Val Asp Gly
145                 150                 155                 160 
Asn Asn Ser Cys Ser Gly Arg Val Glu Val Lys Phe Gln Glu Arg Trp
                165                 170                 175     
Gly Thr Ile Cys Asp Asp Gly Trp Asn Leu Asn Thr Ala Ala Val Val
            180                 185                 190         
Cys Arg Gln Leu Gly Cys Pro Ser Ser Phe Ile Ser Ser Gly Val Val
        195                 200                 205             
Asn Ser Pro Ala Val Leu Arg Pro Ile Trp Leu Asp Asp Ile Leu Cys
    210                 215                 220                 
Gln Gly Asn Glu Leu Ala Leu Trp Asn Cys Arg His Arg Gly Trp Gly
225                 230                 235                 240 
Asn His Asp Cys Ser His Asn Glu Asp Val Thr Leu Thr Cys Tyr Asp
                245                 250                 255     
Ser Ser Asp Leu Glu Leu Arg Leu Val Gly Gly Thr Asn Arg Cys Met
            260                 265                 270         
Gly Arg Val Glu Leu Lys Ile Gln Gly Arg Trp Gly Thr Val Cys His
        275                 280                 285             
His Lys Trp Asn Asn Ala Ala Ala Asp Val Val Cys Lys Gln Leu Gly
    290                 295                 300                 
Cys Gly Thr Ala Leu His Phe Ala Gly Leu Pro His Leu Gln Ser Gly
305                 310                 315                 320 
Ser Asp Val Val Trp Leu Asp Gly Val Ser Cys Ser Gly Asn Glu Ser
                325                 330                 335     
Phe Leu Trp Asp Cys Arg His Ser Gly Thr Val Asn Phe Asp Cys Leu
            340                 345                 350         
His Gln Asn Asp Val Ser Val Ile Cys Ser Asp Gly Ala Asp Leu Glu
        355                 360                 365             
Leu Arg Leu Ala Asp Gly Ser Asn Asn Cys Ser Gly Arg Val Glu Val
    370                 375                 380                 
Arg Ile His Glu Gln Trp Trp Thr Ile Cys Asp Gln Asn Trp Lys Asn
385                 390                 395                 400 
Glu Gln Ala Leu Val Val Cys Lys Gln Leu Gly Cys Pro Phe Ser Val
                405                 410                 415     
Phe Gly Ser Arg Arg Ala Lys Pro Ser Asn Glu Ala Arg Asp Ile Trp
            420                 425                 430         
Ile Asn Ser Ile Ser Cys Thr Gly Asn Glu Ser Ala Leu Trp Asp Cys
        435                 440                 445             
Thr Tyr Asp Gly Lys Ala Lys Arg Thr Cys Phe Arg Arg Ser Asp Ala
    450                 455                 460                 
Gly Val Ile Cys Ser Asp Lys Ala Asp Leu Asp Leu Arg Leu Val Gly
465                 470                 475                 480 
Ala His Ser Pro Cys Tyr Gly Arg Leu Glu Val Lys Tyr Gln Gly Glu
                485                 490                 495     
Trp Gly Thr Val Cys His Asp Arg Trp Ser Thr Arg Asn Ala Ala Val
            500                 505                 510         
Val Cys Lys Gln Leu Gly Cys Gly Lys Pro Met His Val Phe Gly Met
        515                 520                 525             
Thr Tyr Phe Lys Glu Ala Ser Gly Pro Ile Trp Leu Asp Asp Val Ser
    530                 535                 540                 
Cys Ile Gly Asn Glu Ser Asn Ile Trp Asp Cys Glu His Ser Gly Trp
545                 550                 555                 560 
Gly Lys His Asn Cys Val His Arg Glu Asp Val Ile Val Thr Cys Ser
                565                 570                 575     
Gly Asp Ala Thr Trp Gly Leu Arg Leu Val Gly Gly Ser Asn Arg Cys
            580                 585                 590         
Ser Gly Arg Leu Glu Val Tyr Phe Gln Gly Arg Trp Gly Thr Val Cys
        595                 600                 605             
Asp Asp Gly Trp Asn Ser Lys Ala Ala Ala Val Val Cys Ser Gln Leu
    610                 615                 620                 
Asp Cys Pro Ser Ser Ile Ile Gly Met Gly Leu Gly Asn Ala Ser Thr
625                 630                 635                 640 
Gly Tyr Gly Lys Ile Trp Leu Asp Asp Val Ser Cys Asp Gly Asp Glu
                645                 650                 655     
Ser Asp Leu Trp Ser Cys Arg Asn Ser Gly Trp Gly Asn Asn Asp Cys
            660                 665                 670         
Ser His Ser Glu Asp Val Gly Val Ile Cys Ser Asp Ala Ser Asp Met
        675                 680                 685             
Glu Leu Arg Leu Val Gly Gly Ser Ser Arg Cys Ala Gly Lys Val Glu
    690                 695                 700                 
Val Asn Val Gln Gly Ala Val Gly Ile Leu Cys Ala Asn Gly Trp Gly
705                 710                 715                 720 
Met Asn Ile Ala Glu Val Val Cys Arg Gln Leu Glu Cys Gly Ser Ala
                725                 730                 735     
Ile Arg Val Ser Arg Glu Pro His Phe Thr Glu Arg Thr Leu His Ile
            740                 745                 750         
Leu Met Ser Asn Ser Gly Cys Thr Gly Gly Glu Ala Ser Leu Trp Asp
        755                 760                 765             
Cys Ile Arg Trp Glu Trp Lys Gln Thr Ala Cys His Leu Asn Met Glu
    770                 775                 780                 
Ala Ser Leu Ile Cys Ser Ala His Arg Gln Pro Arg Leu Val Gly Ala
785                 790                 795                 800 
Asp Met Pro Cys Ser Gly Arg Val Glu Val Lys His Ala Asp Thr Trp
                805                 810                 815     
Arg Ser Val Cys Asp Ser Asp Phe Ser Leu His Ala Ala Asn Val Leu
            820                 825                 830         
Cys Arg Glu Leu Asn Cys Gly Asp Ala Ile Ser Leu Ser Val Gly Asp
        835                 840                 845             
His Phe Gly Lys Gly Asn Gly Leu Thr Trp Ala Glu Lys Phe Gln Cys
    850                 855                 860                 
Glu Gly Ser Glu Thr His Leu Ala Leu Cys Pro Ile Val Gln His Pro
865                 870                 875                 880 
Glu Asp Thr Cys Ile His Ser Arg Glu Val Gly Val Val Cys Ser Arg
                885                 890                 895     
Tyr Thr Asp Val Arg Leu Val Asn Gly Lys Ser Gln Cys Asp Gly Gln
            900                 905                 910         
Val Glu Ile Asn Val Leu Gly His Trp Gly Ser Leu Cys Asp Thr His
        915                 920                 925             
Trp Asp Pro Glu Asp Ala Arg Val Leu Cys Arg Gln Leu Ser Cys Gly
    930                 935                 940                 
Thr Ala Leu Ser Thr Thr Gly Gly Lys Tyr Ile Gly Glu Arg Ser Val
945                 950                 955                 960 
Arg Val Trp Gly His Arg Phe His Cys Leu Gly Asn Glu Ser Leu Leu
                965                 970                 975     
Asp Asn Cys Gln Met Thr Val Leu Gly Ala Pro Pro Cys Ile His Gly
            980                 985                 990         
Asn Thr Val Ser Val Ile Cys Thr Gly Ser Leu Thr Gln Pro Leu Phe
        995                 1000                1005            
Pro Cys Leu Ala Asn Val Ser Asp Pro Tyr Leu Ser Ala Val Pro Glu
    1010                1015                1020                
Gly Ser Ala Leu Ile Cys Leu Glu Asp Lys Arg Leu Arg Leu Val Asp
1025                1030                1035                1040
Gly Asp Ser Arg Cys Ala Gly Arg Val Glu Ile Tyr His Asp Gly Phe
                1045                1050                1055    
Trp Gly Thr Ile Cys Asp Asp Gly Trp Asp Leu Ser Asp Ala His Val
            1060                1065                1070        
Val Cys Gln Lys Leu Gly Cys Gly Val Ala Phe Asn Ala Thr Val Ser
        1075                1080                1085            
Ala His Phe Gly Glu Gly Ser Gly Pro Ile Trp Leu Asp Asp Leu Asn
    1090                1095                1100                
Cys Thr Gly Met Glu Ser His Leu Trp Gln Cys Pro Ser Arg Gly Trp
1105                1110                1115                1120
Gly Gln His Asp Cys Arg His Lys Glu Asp Ala Gly Val Ile Cys Ser
                1125                1130                1135    
Glu Phe Thr Ala Leu Arg Leu Tyr Ser Glu Thr Glu Thr Glu Ser Cys
            1140                1145                1150        
Ala Gly Arg Leu Glu Val Phe Tyr Asn Gly Thr Trp Gly Ser Val Gly
        1155                1160                1165            
Arg Arg Asn Ile Thr Thr Ala Ile Ala Gly Ile Val Cys Arg Gln Leu
    1170                1175                1180                
Gly Cys Gly Glu Asn Gly Val Val Ser Leu Ala Pro Leu Ser Lys Thr
1185                1190                1195                1200
Gly Ser Gly Phe Met Trp Val Asp Asp Ile Gln Cys Pro Lys Thr His
                1205                1210                1215    
Ile Ser Ile Trp Gln Cys Leu Ser Ala Pro Trp Glu Arg Arg Ile Ser
            1220                1225                1230        
Ser Thr Ala Glu Glu Thr Trp Ile Thr Cys Glu Asp Arg Ile Arg Val
        1235                1240                1245            
Arg Gly Gly Asp Thr Glu Cys Ser Gly Arg Val Glu Ile Trp His Ala
    1250                1255                1260                
Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Leu Ala Glu Ala
1265                1270                1275                1280
Glu Val Val Cys Gln Gln Leu Gly Cys Gly Ser Ala Leu Ala Ala Leu
                1285                1290                1295    
Arg Asp Ala Ser Phe Gly Gln Gly Thr Gly Thr Ile Trp Leu Asp Asp
            1300                1305                1310        
Met Arg Cys Lys Gly Asn Glu Ser Phe Leu Trp Asp Cys His Ala Lys
        1315                1320                1325            
Pro Trp Gly Gln Ser Asp Cys Gly His Lys Glu Asp Ala Gly Val Arg
    1330                1335                1340                
Cys Ser Gly Gln Ser Leu Lys Ser Leu Asn Ala Ser Ser Gly Arg Leu
1345                1350                1355                1360
Ala Leu Ile Leu Ser Ser Ile Phe Gly Leu Leu Leu Pro Val Leu Phe
                1365                1370                1375    
Ile Leu Phe Leu Thr Trp Cys Arg Val Gln Lys Gln Lys His Leu Pro
            1380                1385                1390        
Leu Arg Val Ser Thr Arg Arg Arg Gly Ser Leu Glu Glu Asn Leu Phe
        1395                1400                1405            
His Glu Met Glu Thr Cys Leu Lys Arg Glu Asp Pro His Gly Thr Arg
    1410                1415                1420                
Thr Ser Asp Asp Thr Pro Asn His Gly Cys Glu Asp Ala Ser Asp Thr
1425                1430                1435                1440
Ser Leu Leu Gly Val Leu Pro Ala Ser Glu Ala Thr Lys
                1445                1450            


<210> 2320
<211> 474
<212> PRT
<213> Homo sapiens

<400> 2320
Met Leu Glu Pro Ala Leu Ala Thr Gly Glu Glu Leu Pro Glu Leu Thr
 1               5                  10                  15      
Leu Leu Thr Thr Leu Leu Glu Gly Pro Gly Asp Lys Thr Gln Pro Pro
            20                  25                  30          
Glu Glu Glu Thr Leu Ser Gln Ala Pro Glu Ser Glu Glu Glu Gln Lys
        35                  40                  45              
Lys Lys Ala Leu Glu Arg Ser Met Tyr Val Leu Ser Glu Leu Val Glu
    50                  55                  60                  
Thr Glu Lys Met Tyr Val Asp Asp Leu Gly Gln Ile Val Glu Gly Tyr
65                  70                  75                  80  
Met Ala Thr Met Ala Ala Gln Gly Val Pro Glu Ser Leu Arg Gly Arg
                85                  90                  95      
Asp Arg Ile Val Phe Gly Asn Ile Gln Gln Ile Tyr Glu Trp His Arg
            100                 105                 110         
Asp Tyr Phe Leu Gln Glu Leu Gln Arg Cys Leu Lys Asp Pro Asp Trp
        115                 120                 125             
Leu Ala Gln Leu Phe Ile Lys His Glu Arg Arg Leu His Met Tyr Val
    130                 135                 140                 
Val Tyr Cys Gln Asn Lys Pro Lys Ser Glu His Val Val Ser Glu Phe
145                 150                 155                 160 
Gly Asp Ser Tyr Phe Glu Glu Leu Arg Gln Gln Leu Gly His Arg Leu
                165                 170                 175     
Gln Leu Asn Asp Leu Leu Ile Lys Pro Val Gln Arg Ile Met Lys Tyr
            180                 185                 190         
Gln Leu Leu Leu Lys Asp Phe Leu Lys Tyr Tyr Asn Arg Ala Gly Met
        195                 200                 205             
Asp Thr Ala Asp Leu Glu Gln Ala Val Glu Val Met Cys Phe Val Pro
    210                 215                 220                 
Lys Arg Cys Asn Asp Met Met Thr Leu Gly Arg Leu Arg Gly Phe Glu
225                 230                 235                 240 
Gly Lys Leu Thr Ala Gln Gly Lys Leu Leu Gly Gln Asp Thr Phe Trp
                245                 250                 255     
Val Thr Glu Pro Glu Ala Gly Gly Leu Leu Ser Ser Arg Gly Arg Glu
            260                 265                 270         
Arg Arg Val Phe Leu Phe Glu Gln Ile Ile Ile Phe Ser Glu Ala Leu
        275                 280                 285             
Gly Gly Gly Val Arg Gly Gly Thr Gln Pro Gly Tyr Val Tyr Lys Asn
    290                 295                 300                 
Ser Ile Lys Val Ser Cys Leu Gly Leu Glu Gly Asn Leu Gln Gly Asp
305                 310                 315                 320 
Pro Cys Arg Phe Ala Leu Thr Ser Arg Gly Pro Glu Gly Gly Ile Gln
                325                 330                 335     
Arg Tyr Val Leu Gln Ala Ala Asp Pro Ala Ile Ser Gln Ala Trp Ile
            340                 345                 350         
Lys His Val Ala Gln Ile Leu Glu Ser Gln Arg Asp Phe Leu Asn Ala
        355                 360                 365             
Leu Gln Ser Pro Ile Glu Tyr Gln Arg Arg Glu Ser Gln Thr Asn Ser
    370                 375                 380                 
Leu Gly Arg Pro Arg Gly Pro Gly Val Gly Ser Pro Gly Arg Ile Arg
385                 390                 395                 400 
Leu Gly Asp Gln Ala Gln Gly Ser Thr His Thr Pro Ile Asn Gly Ser
                405                 410                 415     
Leu Pro Ser Leu Leu Leu Ser Pro Lys Gly Glu Val Ala Arg Ala Leu
            420                 425                 430         
Leu Pro Leu Asp Lys Gln Ala Leu Gly Asp Ile Pro Gln Ala Pro His
        435                 440                 445             
Asp Ser Pro Pro Val Ser Pro Thr Pro Lys Thr Pro Pro Cys Gln Ala
    450                 455                 460                 
Arg Leu Ala Lys Leu Asp Glu Asp Glu Leu
465                 470                 


<210> 2321
<211> 609
<212> PRT
<213> Homo sapiens

<400> 2321
Met Ser Thr Ala Pro Ser Leu Ser Ala Leu Arg Ser Ser Lys His Ser
 1               5                  10                  15      
Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Asp Pro Ala Trp
            20                  25                  30          
Thr Ser Ala Leu Ser Gly Asn Ser Ser Gly Pro Gly Pro Gly Ser Ser
        35                  40                  45              
Pro Ala Gly Ser Thr Lys Pro Phe Val His Ala Val Pro Pro Ser Asp
    50                  55                  60                  
Pro Leu Arg Gln Ala Asn Arg Leu Pro Ile Lys Val Leu Lys Met Leu
65                  70                  75                  80  
Thr Ala Arg Thr Gly His Ile Leu His Pro Glu Tyr Leu Gln Pro Leu
                85                  90                  95      
Pro Ser Thr Pro Val Ser Pro Ile Glu Leu Asp Ala Lys Lys Ser Pro
            100                 105                 110         
Leu Ala Leu Leu Ala Gln Thr Cys Ser Gln Ile Gly Lys Pro Asp Pro
        115                 120                 125             
Ser Pro Ser Ser Lys Leu Ser Ser Val Ala Ser Asn Gly Gly Gly Ala
    130                 135                 140                 
Gly Gly Ala Gly Gly Gly Ala Ala Gly Asp Lys Asp Thr Lys Ser Gly
145                 150                 155                 160 
Pro Leu Lys Leu Ser Asp Ile Gly Val Glu Asp Lys Ser Ser Phe Lys
                165                 170                 175     
Pro Tyr Ser Lys Pro Gly Ser Asp Lys Lys Glu Pro Gly Gly Gly Gly
            180                 185                 190         
Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Val Ser Ser Glu
        195                 200                 205             
Lys Ser Gly Phe Arg Val Pro Ser Ala Thr Cys Gln Pro Phe Thr Pro
    210                 215                 220                 
Arg Thr Gly Ser Pro Ser Ser Ser Ala Ser Ala Glu Gly Gly Pro Thr
225                 230                 235                 240 
Gly Leu Ala His Gly Arg Ile Ser Cys Gly Gly Gly Ile Asn Val Asp
                245                 250                 255     
Val Asn Gln His Pro Asp Gly Gly Pro Gly Gly Lys Ala Leu Gly Ser
            260                 265                 270         
Asp Cys Gly Gly Ser Ser Gly Ser Ser Ser Gly Ser Gly Pro Ser Ala
        275                 280                 285             
Pro Thr Ser Ser Ser Val Leu Gly Ser Gly Leu Val Ala Pro Val Ser
    290                 295                 300                 
Pro Tyr Lys Pro Gly Gln Thr Val Phe Pro Leu Pro Pro Ala Gly Met
305                 310                 315                 320 
Thr Tyr Pro Gly Ser Leu Ala Gly Ala Tyr Ala Gly Tyr Pro Pro Gln
                325                 330                 335     
Phe Leu Pro His Gly Val Ala Leu Asp Pro Thr Lys Pro Gly Ser Leu
            340                 345                 350         
Val Gly Ala Gln Leu Ala Ala Ala Ala Ala Gly Ser Leu Gly Cys Ser
        355                 360                 365             
Lys Pro Ala Gly Ser Ser Pro Leu Ala Gly Ala Ser Pro Pro Ser Val
    370                 375                 380                 
Met Thr Ala Ser Leu Cys Arg Asp Pro Tyr Cys Leu Ser Tyr His Cys
385                 390                 395                 400 
Ala Ser His Leu Ala Gly Ala Ala Ala Ala Ser Ala Ser Cys Ala His
                405                 410                 415     
Asp Pro Ala Ala Ala Ala Ala Ala Leu Lys Ser Gly Tyr Pro Leu Val
            420                 425                 430         
Tyr Pro Thr His Pro Leu His Gly Val His Ser Ser Leu Thr Ala Ala
        435                 440                 445             
Ala Ala Ala Gly Ala Thr Pro Pro Ser Leu Ala Gly His Pro Leu Tyr
    450                 455                 460                 
Pro Tyr Gly Phe Met Leu Pro Asn Asp Pro Leu Pro His Ile Cys Asn
465                 470                 475                 480 
Trp Val Ser Ala Asn Gly Pro Cys Asp Lys Arg Phe Ala Thr Ser Glu
                485                 490                 495     
Glu Leu Leu Ser His Leu Arg Thr His Thr Ala Phe Pro Gly Thr Asp
            500                 505                 510         
Lys Leu Leu Ser Gly Tyr Pro Ser Ser Ser Ser Leu Ala Ser Ala Ala
        515                 520                 525             
Ala Ala Ala Met Ala Cys His Met His Ile Pro Thr Ser Gly Ala Pro
    530                 535                 540                 
Gly Ser Pro Gly Thr Leu Ala Leu Arg Ser Pro His His Ala Leu Gly
545                 550                 555                 560 
Leu Ser Ser Arg Tyr His Pro Tyr Ser Lys Ser Pro Leu Pro Thr Pro
                565                 570                 575     
Gly Ala Pro Val Pro Val Pro Ala Ala Thr Gly Pro Tyr Tyr Ser Pro
            580                 585                 590         
Tyr Ala Leu Tyr Gly Gln Arg Leu Thr Thr Ala Ser Ala Leu Gly Tyr
        595                 600                 605             
Gln
    


<210> 2322
<211> 756
<212> PRT
<213> Homo sapiens

<400> 2322
Met Pro Ser Val Ser Lys Ala Ala Ala Ala Ala Leu Ser Gly Ser Pro
 1               5                  10                  15      
Pro Gln Thr Glu Lys Pro Thr His Tyr Arg Tyr Leu Lys Glu Phe Arg
            20                  25                  30          
Thr Glu Gln Cys Pro Leu Phe Ser Gln His Lys Cys Ala Gln His Arg
        35                  40                  45              
Pro Phe Thr Cys Phe His Trp His Phe Leu Asn Gln Arg Arg Arg Arg
    50                  55                  60                  
Pro Leu Arg Arg Arg Asp Gly Thr Phe Asn Tyr Ser Pro Asp Val Tyr
65                  70                  75                  80  
Cys Ser Lys Tyr Asn Glu Ala Thr Gly Val Cys Pro Asp Gly Asp Glu
                85                  90                  95      
Ser Leu Leu Gly Val Leu Tyr Pro Leu Trp Ala Pro Pro Pro Val Pro
            100                 105                 110         
Ala Pro Val Gly Ala Pro Thr Val His Pro Phe Leu Ala Arg Trp Phe
        115                 120                 125             
Ser His Val Pro Trp Glu Pro Ala Gly Ser Ala Asp Pro Arg Ala Ser
    130                 135                 140                 
Ser Thr Pro Ala Gly Gly Thr Thr Trp Ala Thr Gly Leu Leu Gly Asp
145                 150                 155                 160 
Phe Asp Ala Cys Gly Ser Gln Ser Arg Glu Cys Val Lys Gly Val Trp
                165                 170                 175     
Trp Thr Leu Leu Gly Phe Arg Cys Pro Tyr Leu His Arg Thr Thr Gly
            180                 185                 190         
Asp Thr Glu Arg Lys Tyr His Leu Arg Tyr Tyr Lys Thr Gly Thr Cys
        195                 200                 205             
Ile His Glu Thr Asp Ala Arg Gly His Cys Val Lys Asn Gly Leu His
    210                 215                 220                 
Cys Ala Phe Ala His Gly Pro Leu Asp Leu Arg Pro Pro Val Cys Asp
225                 230                 235                 240 
Val Arg Glu Leu Gln Ala Gln Glu Ala Leu Gln Asn Gly Gln Leu Gly
                245                 250                 255     
Gly Gly Glu Gly Val Pro Asp Leu Gln Pro Gly Val Leu Ala Ser Gln
            260                 265                 270         
Ala Met Ile Glu Lys Ile Leu Ser Glu Asp Pro Arg Trp Gln Ala Leu
        275                 280                 285             
Leu Pro Val Ala Leu Leu Arg His Arg Val Ala His Phe Ser Asp Ala
    290                 295                 300                 
Asn Phe Val Leu Gly Ser Tyr Lys Thr Glu Gln Cys Pro Lys Pro Pro
305                 310                 315                 320 
Arg Leu Cys Arg Gln Gly Tyr Ala Cys Pro His Tyr His Asn Ser Arg
                325                 330                 335     
Asp Arg Arg Arg Asn Pro Arg Arg Phe Gln Tyr Arg Ser Thr Pro Cys
            340                 345                 350         
Pro Ser Val Lys His Gly Asp Glu Trp Gly Glu Pro Ser Arg Cys Asp
        355                 360                 365             
Gly Gly Asp Gly Cys Gln Tyr Cys His Ser Arg Thr Glu Gln Gln Phe
    370                 375                 380                 
His Pro Glu Gly Pro Val Gly Ser Pro Val Ser Gly Ala Phe Ser Val
385                 390                 395                 400 
Phe Ser His Ala Gly Leu Val Ala Asp Pro Ser Leu Trp Tyr Pro Ala
                405                 410                 415     
Glu Trp Ser Trp His His Val Gly His Ser Arg Thr Ile Asn Pro Glu
            420                 425                 430         
Gly Asp Lys Pro Ser Arg Leu Gly Pro Ala Pro Glu Asn Ile Lys Arg
        435                 440                 445             
Gly Asn Asp Phe Ala Cys Asp Gly Arg Ala Asp Ala Ala Gly Met Ala
    450                 455                 460                 
Pro His Val Cys Val Phe Pro Ile Tyr Lys Ser Thr Lys Cys Asn Asp
465                 470                 475                 480 
Met Arg Gln Thr Gly Tyr Cys Pro Arg Gly Pro Phe Cys Ala Phe Ala
                485                 490                 495     
His Val Glu Lys Ser Leu Gly Met Val Asn Glu Trp Gly Cys His Asp
            500                 505                 510         
Leu His Leu Thr Ser Pro Ser Ser Thr Gly Ser Gly Gln Pro Gly Asn
        515                 520                 525             
Ala Lys Arg Arg Asp Ser Pro Ala Glu Gly Gly Pro Arg Gly Ser Glu
    530                 535                 540                 
Gln Asp Ser Lys Gln Gly Val Arg Ala His Gly Val Tyr Val Phe Glu
545                 550                 555                 560 
Gln Asn His Leu Ala Val Phe Ala Ala Val His Pro Pro Ala Pro Ser
                565                 570                 575     
Val Ser Ser Ser Val Ala Ser Ser Leu Ala Ser Ser Ala Gly Ser Gly
            580                 585                 590         
Ser Ser Ser Pro Thr Ala Leu Pro Ala Pro Pro Ala Arg Ala Leu Pro
        595                 600                 605             
Leu Gly Pro Ala Ser Ser Thr Val Glu Ala Val Leu Ala Leu Glu Pro
    610                 615                 620                 
Thr Pro Ser Ser Pro Thr Ser Ser Ala Val Gln Gly Val Ala Gly Glu
625                 630                 635                 640 
Leu Gly Met Gly Ser Gly Gly Gln Gly Cys Trp Ser His Val Val Gly
                645                 650                 655     
Ala Leu Ala Ala Val Pro Ala Trp Thr His Ser Gly Asp Leu Glu Trp
            660                 665                 670         
Asp Pro Ser Thr Ile Arg Thr Arg Val Asn Val Gly Gly Gly Pro Ala
        675                 680                 685             
Ala Arg Pro Ala Met Thr Leu Ala Arg Glu Pro Gln Leu Leu Val Val
    690                 695                 700                 
Gly Gly Cys Pro Thr Arg Asn Cys Ser Gly Pro Ala Ala Ser Pro Gln
705                 710                 715                 720 
Gln Leu Leu Asp Asp Ala Gly Gln Gly Gly Arg Gly Glu Arg Asp Ser
                725                 730                 735     
Ser Gln Arg Pro Leu Arg Pro Gln Thr Thr His Arg Gln Asp Thr Arg
            740                 745                 750         
Pro Val Pro Ser
        755     


<210> 2323
<211> 515
<212> PRT
<213> Homo sapiens

<400> 2323
Met Ala Phe Met Glu Lys Pro Pro Ala Gly Lys Val Leu Leu Asp Asp
 1               5                  10                  15      
Thr Val Pro Leu Thr Ala Ala Ile Glu Ala Ser Gln Ser Leu Gln Ser
            20                  25                  30          
His Thr Glu Tyr Ile Ile Arg Val Gln Gly Gly Ile Ser Val Glu Asn
        35                  40                  45              
Ser Trp Gln Ile Val Arg Arg Tyr Ser Asp Phe Asp Leu Leu Asn Asn
    50                  55                  60                  
Ser Leu Gln Ile Ala Gly Leu Ser Leu Pro Leu Pro Pro Lys Lys Leu
65                  70                  75                  80  
Ile Gly Asn Met Asp Arg Glu Phe Ile Ala Glu Arg Gln Lys Gly Leu
                85                  90                  95      
Gln Asn Tyr Leu Asn Val Ile Thr Thr Asn His Ile Leu Ser Asn Cys
            100                 105                 110         
Glu Leu Val Lys Lys Phe Leu Asp Pro Asn Asn Tyr Ser Ala Asn Tyr
        115                 120                 125             
Thr Glu Ile Ala Leu Gln Gln Val Ser Met Phe Phe Arg Ser Glu Pro
    130                 135                 140                 
Lys Trp Glu Val Val Glu Pro Leu Lys Asp Ile Gly Trp Arg Ile Arg
145                 150                 155                 160 
Lys Lys Tyr Phe Leu Met Lys Ile Lys Asn Gln Pro Lys Glu Arg Leu
                165                 170                 175     
Val Leu Ser Trp Ala Asp Leu Gly Pro Asp Lys Tyr Leu Ser Asp Lys
            180                 185                 190         
Asp Phe Gln Cys Leu Ile Lys Leu Leu Pro Ser Cys Leu His Pro Tyr
        195                 200                 205             
Ile Tyr Arg Val Thr Phe Ala Thr Ala Asn Glu Ser Ser Ala Leu Leu
    210                 215                 220                 
Ile Arg Met Phe Asn Glu Lys Gly Thr Leu Lys Asp Leu Ile Tyr Lys
225                 230                 235                 240 
Ala Lys Pro Lys Asp Pro Phe Leu Lys Lys Tyr Cys Asn Pro Lys Lys
                245                 250                 255     
Ile Gln Gly Leu Glu Leu Gln Gln Ile Lys Thr Tyr Gly Arg Gln Ile
            260                 265                 270         
Leu Glu Val Leu Lys Phe Leu His Asp Lys Gly Phe Pro Tyr Gly His
        275                 280                 285             
Leu His Ala Ser Asn Val Met Leu Asp Gly Asp Thr Cys Arg Leu Leu
    290                 295                 300                 
Asp Leu Glu Asn Ser Leu Leu Gly Leu Pro Ser Phe Tyr Arg Ser Tyr
305                 310                 315                 320 
Phe Ser Gln Phe Arg Lys Ile Asn Thr Leu Glu Ser Val Asp Val His
                325                 330                 335     
Cys Phe Gly His Leu Leu Tyr Glu Met Thr Tyr Gly Arg Pro Pro Asp
            340                 345                 350         
Ser Val Pro Val Asp Ser Phe Pro Pro Ala Pro Ser Met Ala Val Val
        355                 360                 365             
Ala Val Leu Glu Ser Thr Leu Ser Cys Glu Ala Cys Lys Asn Gly Met
    370                 375                 380                 
Pro Thr Ile Ser Arg Leu Leu Gln Met Pro Leu Phe Ser Asp Val Leu
385                 390                 395                 400 
Leu Thr Thr Ser Glu Lys Pro Gln Phe Lys Ile Pro Thr Lys Leu Lys
                405                 410                 415     
Glu Ala Leu Arg Ile Ala Lys Glu Cys Ile Glu Lys Arg Leu Ile Glu
            420                 425                 430         
Glu Gln Lys Gln Ile His Gln His Arg Arg Leu Thr Arg Ala Gln Ser
        435                 440                 445             
His His Gly Ser Glu Glu Glu Arg Lys Lys Arg Lys Ile Leu Ala Arg
    450                 455                 460                 
Lys Lys Ser Lys Arg Ser Ala Leu Glu Asn Ser Glu Glu His Ser Ala
465                 470                 475                 480 
Arg Tyr Ser Asn Ser Asn Asn Ser Ala Gly Ser Gly Ala Ser Ser Pro
                485                 490                 495     
Leu Thr Ser Pro Ser Ser Pro Thr Pro Pro Ser Thr Ser Val Glu His
            500                 505                 510         
Ala Pro Phe
        515 


<210> 2324
<211> 215
<212> PRT
<213> Homo sapiens

<400> 2324
Met Ala Ser Arg Gly Ala Thr Arg Pro Asn Gly Pro Asn Thr Gly Asn
 1               5                  10                  15      
Lys Ile Cys Gln Phe Lys Leu Val Leu Leu Gly Glu Ser Ala Val Gly
            20                  25                  30          
Lys Ser Ser Leu Val Leu Arg Phe Val Lys Gly Gln Phe His Glu Phe
        35                  40                  45              
Gln Glu Ser Thr Ile Gly Ala Ala Phe Leu Thr Gln Thr Val Cys Leu
    50                  55                  60                  
Asp Asp Thr Thr Val Lys Phe Glu Ile Trp Asp Thr Ala Gly Gln Glu
65                  70                  75                  80  
Arg Tyr His Ser Leu Ala Pro Met Tyr Tyr Arg Gly Ala Gln Ala Ala
                85                  90                  95      
Ile Val Val Tyr Asp Ile Thr Asn Glu Glu Ser Phe Ala Arg Ala Lys
            100                 105                 110         
Asn Trp Val Lys Glu Leu Gln Arg Gln Ala Ser Pro Asn Ile Val Ile
        115                 120                 125             
Ala Leu Ser Gly Asn Lys Ala Asp Leu Ala Asn Lys Arg Ala Val Asp
    130                 135                 140                 
Phe Gln Glu Ala Gln Ser Tyr Ala Asp Asp Asn Ser Leu Leu Phe Met
145                 150                 155                 160 
Glu Thr Ser Ala Lys Thr Ser Met Asn Val Asn Glu Ile Phe Met Ala
                165                 170                 175     
Ile Ala Lys Lys Leu Pro Lys Asn Glu Pro Gln Asn Pro Gly Ala Asn
            180                 185                 190         
Ser Ala Arg Gly Arg Gly Val Asp Leu Thr Glu Pro Thr Gln Pro Thr
        195                 200                 205             
Arg Asn Gln Cys Cys Ser Asn
    210                 215 


<210> 2325
<211> 215
<212> PRT
<213> Homo sapiens

<400> 2325
Met Ala Ser Arg Gly Ala Thr Arg Pro Asn Gly Pro Asn Thr Gly Asn
 1               5                  10                  15      
Lys Ile Cys Gln Phe Lys Leu Val Leu Leu Gly Glu Ser Ala Val Gly
            20                  25                  30          
Lys Ser Ser Leu Val Leu Arg Phe Val Lys Gly Gln Phe His Glu Phe
        35                  40                  45              
Gln Glu Ser Thr Ile Gly Ala Ala Phe Leu Thr Gln Thr Val Cys Leu
    50                  55                  60                  
Asp Asp Thr Thr Val Lys Phe Glu Ile Trp Asp Thr Ala Gly Gln Glu
65                  70                  75                  80  
Arg Tyr His Ser Leu Ala Pro Met Tyr Tyr Arg Gly Ala Gln Ala Ala
                85                  90                  95      
Ile Val Val Tyr Asp Ile Thr Asn Glu Glu Ser Phe Ala Arg Ala Lys
            100                 105                 110         
Asn Trp Val Lys Glu Leu Gln Arg Gln Ala Ser Pro Asn Ile Val Ile
        115                 120                 125             
Ala Leu Ser Gly Asn Lys Ala Asp Leu Ala Asn Lys Arg Ala Val Asp
    130                 135                 140                 
Phe Gln Glu Ala Gln Ser Tyr Ala Asp Asp Asn Ser Leu Leu Phe Met
145                 150                 155                 160 
Glu Thr Ser Ala Lys Thr Ser Met Asn Val Asn Glu Ile Phe Met Ala
                165                 170                 175     
Ile Ala Lys Lys Leu Pro Lys Asn Glu Pro Gln Asn Pro Gly Ala Asn
            180                 185                 190         
Ser Ala Arg Gly Arg Gly Val Asp Leu Thr Glu Pro Thr Gln Pro Thr
        195                 200                 205             
Arg Asn Gln Cys Cys Ser Asn
    210                 215 


<210> 2326
<211> 3149
<212> PRT
<213> Homo sapiens

<400> 2326
Met Gly Asn Glu Val Ser Leu Glu Gly Gly Ala Gly Asp Gly Pro Leu
 1               5                  10                  15      
Pro Pro Gly Gly Ala Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly
            20                  25                  30          
Ala Gly Lys Pro Pro Ser Ala Pro Ala Gly Gly Gly Gln Leu Pro Ala
        35                  40                  45              
Ala Gly Ala Ala Arg Ser Thr Ala Val Pro Pro Val Pro Gly Pro Gly
    50                  55                  60                  
Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Ser Thr Ser Arg Arg Leu
65                  70                  75                  80  
Asp Pro Lys Glu Pro Leu Gly Asn Gln Arg Ala Ala Ser Pro Thr Pro
                85                  90                  95      
Lys Gln Ala Ser Ala Thr Thr Pro Gly His Glu Ser Pro Arg Glu Thr
            100                 105                 110         
Arg Ala Gln Gly Pro Ala Gly Gln Glu Ala Asp Gly Pro Arg Arg Thr
        115                 120                 125             
Leu Gln Val Asp Ser Arg Thr Gln Arg Ser Gly Arg Ser Pro Ser Val
    130                 135                 140                 
Ser Pro Asp Arg Gly Ser Thr Pro Thr Ser Pro Tyr Ser Val Pro Gln
145                 150                 155                 160 
Ile Ala Pro Leu Pro Ser Ser Thr Leu Cys Pro Ile Cys Lys Thr Ser
                165                 170                 175     
Asp Leu Thr Ser Thr Pro Ser Gln Pro Asn Phe Asn Thr Cys Thr Gln
            180                 185                 190         
Cys His Asn Lys Val Cys Asn Gln Cys Gly Phe Asn Pro Asn Pro His
        195                 200                 205             
Leu Thr Gln Val Lys Glu Trp Leu Cys Leu Asn Cys Gln Met Gln Arg
    210                 215                 220                 
Ala Leu Gly Met Asp Met Thr Thr Ala Pro Arg Ser Lys Ser Gln Gln
225                 230                 235                 240 
Gln Leu His Ser Pro Ala Leu Ser Pro Ala His Ser Pro Ala Lys Gln
                245                 250                 255     
Pro Leu Gly Lys Pro Asp Gln Glu Arg Ser Arg Gly Pro Gly Gly Pro
            260                 265                 270         
Gln Pro Gly Ser Arg Gln Ala Glu Thr Ala Arg Ala Thr Ser Val Pro
        275                 280                 285             
Gly Pro Ala Gln Ala Ala Ala Pro Pro Glu Val Gly Arg Val Ser Pro
    290                 295                 300                 
Gln Pro Pro Gln Pro Thr Lys Pro Ser Thr Ala Glu Pro Arg Pro Pro
305                 310                 315                 320 
Ala Gly Glu Ala Pro Ala Lys Ser Ala Thr Ala Val Pro Ala Gly Leu
                325                 330                 335     
Gly Ala Thr Glu Gln Thr Gln Glu Gly Leu Thr Gly Lys Leu Phe Gly
            340                 345                 350         
Leu Gly Ala Ser Leu Leu Thr Gln Ala Ser Thr Leu Met Ser Val Gln
        355                 360                 365             
Pro Glu Ala Asp Thr Gln Gly Gln Pro Ala Pro Ser Lys Gly Thr Pro
    370                 375                 380                 
Lys Ile Val Phe Asn Asp Ala Ser Lys Glu Ala Gly Pro Lys Pro Leu
385                 390                 395                 400 
Gly Ser Gly Pro Gly Pro Gly Pro Ala Pro Gly Ala Lys Thr Glu Pro
                405                 410                 415     
Gly Ala Arg Met Gly Pro Gly Ser Gly Pro Gly Ala Leu Pro Lys Thr
            420                 425                 430         
Gly Gly Thr Thr Ser Pro Lys His Gly Arg Ala Glu His Gln Ala Ala
        435                 440                 445             
Ser Lys Ala Ala Ala Lys Pro Lys Thr Met Pro Lys Glu Arg Ala Ile
    450                 455                 460                 
Cys Pro Leu Cys Gln Ala Glu Leu Asn Val Gly Ser Lys Ser Pro Ala
465                 470                 475                 480 
Asn Tyr Asn Thr Cys Thr Thr Cys Arg Leu Gln Val Cys Asn Leu Cys
                485                 490                 495     
Gly Phe Asn Pro Thr Pro His Leu Val Glu Lys Thr Glu Trp Leu Cys
            500                 505                 510         
Leu Asn Cys Gln Thr Lys Arg Leu Leu Glu Gly Ser Leu Gly Glu Pro
        515                 520                 525             
Thr Pro Leu Pro Pro Pro Thr Ser Gln Gln Pro Pro Val Gly Ala Pro
    530                 535                 540                 
His Arg Ala Ser Gly Thr Ser Pro Leu Lys Gln Lys Gly Pro Gln Gly
545                 550                 555                 560 
Leu Gly Gln Pro Ser Gly Pro Leu Pro Ala Lys Ala Ser Pro Leu Ser
                565                 570                 575     
Thr Lys Ala Ser Pro Leu Pro Ser Lys Ala Ser Pro Gln Ala Lys Pro
            580                 585                 590         
Leu Arg Ala Ser Glu Pro Ser Lys Thr Pro Ser Ser Val Gln Glu Lys
        595                 600                 605             
Lys Thr Arg Val Pro Thr Lys Ala Glu Pro Met Pro Lys Pro Pro Pro
    610                 615                 620                 
Glu Thr Thr Pro Thr Pro Ala Thr Pro Lys Val Lys Ser Gly Val Arg
625                 630                 635                 640 
Arg Ala Glu Pro Ala Thr Pro Val Val Lys Ala Val Pro Glu Ala Pro
                645                 650                 655     
Lys Gly Gly Glu Ala Glu Asp Leu Val Gly Lys Pro Tyr Ser Gln Asp
            660                 665                 670         
Ala Ser Arg Ser Pro Gln Ser Leu Ser Asp Thr Gly Tyr Ser Ser Asp
        675                 680                 685             
Gly Ile Ser Ser Ser Gln Ser Glu Ile Thr Gly Val Val Gln Gln Glu
    690                 695                 700                 
Val Glu Gln Leu Asp Ser Ala Gly Val Thr Gly Pro His Pro Pro Ser
705                 710                 715                 720 
Pro Ser Glu Ile His Lys Val Gly Ser Ser Met Arg Pro Leu Leu Gln
                725                 730                 735     
Ala Gln Gly Leu Ala Pro Ser Glu Arg Ser Lys Pro Leu Ser Ser Gly
            740                 745                 750         
Thr Gly Glu Glu Gln Lys Gln Arg Pro His Ser Leu Ser Ile Thr Pro
        755                 760                 765             
Glu Ala Phe Asp Ser Asp Glu Glu Leu Glu Asp Ile Leu Glu Glu Asp
    770                 775                 780                 
Glu Asp Ser Ala Glu Trp Arg Arg Arg Arg Glu Gln Gln Asp Thr Ala
785                 790                 795                 800 
Glu Ser Ser Asp Asp Phe Gly Ser Gln Leu Arg His Asp Tyr Val Glu
                805                 810                 815     
Asp Ser Ser Glu Gly Gly Leu Ser Pro Leu Pro Pro Gln Pro Pro Ala
            820                 825                 830         
Arg Ala Ala Glu Leu Thr Asp Glu Asp Phe Met Arg Arg Gln Ile Leu
        835                 840                 845             
Glu Met Ser Ala Glu Glu Asp Asn Leu Glu Glu Asp Asp Thr Ala Thr
    850                 855                 860                 
Ser Gly Arg Gly Leu Ala Lys His Gly Thr Gln Lys Gly Gly Pro Arg
865                 870                 875                 880 
Pro Arg Pro Glu Pro Ser Gln Glu Pro Ala Ala Leu Pro Lys Arg Arg
                885                 890                 895     
Leu Pro His Asn Ala Thr Thr Gly Tyr Glu Glu Leu Leu Pro Glu Gly
            900                 905                 910         
Gly Ser Ala Glu Ala Thr Asp Gly Ser Gly Thr Leu Gln Gly Gly Leu
        915                 920                 925             
Arg Arg Phe Lys Thr Ile Glu Leu Asn Ser Thr Gly Ser Tyr Gly His
    930                 935                 940                 
Glu Leu Asp Leu Gly Gln Gly Pro Asp Pro Ser Leu Asp Arg Glu Pro
945                 950                 955                 960 
Glu Leu Glu Met Glu Ser Leu Thr Gly Ser Pro Glu Asp Arg Ser Arg
                965                 970                 975     
Gly Glu His Ser Ser Thr Leu Pro Ala Ser Thr Pro Ser Tyr Thr Ser
            980                 985                 990         
Gly Thr Ser Pro Thr Ser Leu Ser Ser Leu Glu Glu Asp Ser Asp Ser
        995                 1000                1005            
Ser Pro Ser Arg Arg Gln Arg Leu Glu Glu Ala Lys Gln Gln Arg Lys
    1010                1015                1020                
Ala Arg His Arg Ser His Gly Pro Leu Leu Pro Thr Ile Glu Asp Ser
1025                1030                1035                1040
Ser Glu Glu Glu Glu Leu Arg Glu Glu Glu Glu Leu Leu Arg Glu Gln
                1045                1050                1055    
Glu Lys Met Arg Glu Val Glu Gln Gln Arg Ile Arg Ser Thr Ala Arg
            1060                1065                1070        
Lys Thr Arg Arg Asp Lys Glu Glu Leu Arg Ala Gln Arg Arg Arg Glu
        1075                1080                1085            
Arg Ser Lys Thr Pro Pro Ser Asn Leu Ser Pro Ile Glu Asp Ala Ser
    1090                1095                1100                
Pro Thr Glu Glu Leu Arg Gln Ala Ala Glu Met Glu Glu Leu His Arg
1105                1110                1115                1120
Ser Ser Cys Ser Glu Tyr Ser Pro Ser Pro Ser Leu Asp Ser Glu Ala
                1125                1130                1135    
Glu Ala Leu Asp Gly Gly Pro Ser Arg Leu Tyr Lys Ser Gly Ser Glu
            1140                1145                1150        
Tyr Asn Leu Pro Thr Phe Met Ser Leu Tyr Ser Pro Thr Glu Thr Pro
        1155                1160                1165            
Ser Gly Ser Ser Thr Thr Pro Ser Ser Gly Arg Pro Leu Lys Ser Ala
    1170                1175                1180                
Glu Glu Ala Tyr Glu Glu Met Met Arg Lys Ala Glu Leu Leu Gln Arg
1185                1190                1195                1200
Gln Gln Gly Gln Ala Ala Gly Ala Arg Gly Pro His Gly Gly Pro Ser
                1205                1210                1215    
Gln Pro Thr Gly Pro Arg Gly Leu Gly Ser Phe Glu Tyr Gln Asp Thr
            1220                1225                1230        
Thr Asp Arg Glu Tyr Gly Gln Ala Ala Gln Pro Ala Ala Glu Gly Thr
        1235                1240                1245            
Pro Ala Ser Leu Gly Ala Ala Val Tyr Glu Glu Ile Leu Gln Thr Ser
    1250                1255                1260                
Gln Ser Ile Val Arg Met Arg Gln Ala Ser Ser Arg Asp Leu Ala Phe
1265                1270                1275                1280
Ala Glu Asp Lys Lys Lys Glu Lys Gln Phe Leu Asn Ala Glu Ser Ala
                1285                1290                1295    
Tyr Met Asp Pro Met Lys Gln Asn Gly Gly Pro Leu Thr Pro Gly Thr
            1300                1305                1310        
Ser Pro Thr Gln Leu Ala Ala Pro Val Ser Phe Ser Thr Pro Thr Ser
        1315                1320                1325            
Ser Asp Ser Ser Gly Gly Arg Val Ile Pro Asp Val Arg Val Thr Gln
    1330                1335                1340                
His Phe Ala Lys Glu Thr Gln Asp Pro Leu Lys Leu His Ser Ser Pro
1345                1350                1355                1360
Ala Ser Pro Ser Ser Ala Ser Lys Glu Ile Gly Met Pro Phe Ser Gln
                1365                1370                1375    
Gly Pro Gly Thr Pro Ala Thr Thr Ala Val Ala Pro Cys Pro Ala Gly
            1380                1385                1390        
Leu Pro Arg Gly Tyr Met Thr Pro Ala Ser Pro Ala Gly Ser Glu Arg
        1395                1400                1405            
Ser Pro Ser Pro Ser Ser Thr Ala His Ser Tyr Gly His Ser Pro Thr
    1410                1415                1420                
Thr Ala Asn Tyr Gly Ser Gln Thr Glu Asp Leu Pro Gln Ala Pro Ser
1425                1430                1435                1440
Gly Leu Ala Ala Ala Gly Arg Ala Ala Arg Glu Lys Pro Leu Ser Ala
                1445                1450                1455    
Ser Asp Gly Glu Gly Gly Thr Pro Gln Pro Ser Arg Ala Tyr Ser Tyr
            1460                1465                1470        
Phe Ala Ser Ser Ser Pro Pro Leu Ser Pro Ser Ser Pro Ser Glu Ser
        1475                1480                1485            
Pro Thr Phe Ser Pro Gly Lys Met Gly Pro Arg Ala Thr Ala Glu Phe
    1490                1495                1500                
Ser Thr Gln Thr Pro Ser Pro Ala Pro Ala Ser Asp Met Pro Arg Ser
1505                1510                1515                1520
Pro Gly Ala Pro Thr Pro Ser Pro Met Val Ala Gln Gly Thr Gln Thr
                1525                1530                1535    
Pro His Arg Pro Ser Thr Pro Arg Leu Val Trp Gln Glu Ser Ser Gln
            1540                1545                1550        
Glu Ala Pro Phe Met Val Ile Thr Leu Ala Ser Asp Ala Ser Ser Gln
        1555                1560                1565            
Thr Arg Met Val His Ala Ser Ala Ser Thr Ser Pro Leu Cys Ser Pro
    1570                1575                1580                
Thr Glu Thr Gln Pro Thr Thr His Gly Tyr Ser Gln Thr Thr Pro Pro
1585                1590                1595                1600
Ser Val Ser Gln Leu Pro Pro Glu Pro Pro Gly Pro Pro Gly Phe Pro
                1605                1610                1615    
Arg Val Pro Ser Ala Gly Ala Asp Gly Pro Leu Ala Leu Tyr Gly Trp
            1620                1625                1630        
Gly Ala Leu Pro Ala Glu Asn Ile Ser Leu Cys Arg Ile Ser Ser Val
        1635                1640                1645            
Pro Gly Thr Ser Arg Val Glu Pro Gly Pro Arg Thr Pro Gly Thr Ala
    1650                1655                1660                
Val Val Asp Leu Arg Thr Ala Val Lys Pro Thr Pro Ile Ile Leu Thr
1665                1670                1675                1680
Asp Gln Gly Met Asp Leu Thr Ser Leu Ala Val Glu Ala Arg Lys Tyr
                1685                1690                1695    
Gly Leu Ala Leu Asp Pro Ile Pro Gly Arg Gln Ser Thr Ala Val Gln
            1700                1705                1710        
Pro Leu Val Ile Asn Leu Asn Ala Gln Glu His Thr Phe Leu Ala Thr
        1715                1720                1725            
Ala Thr Thr Val Ser Ile Thr Met Ala Ser Ser Val Phe Met Ala Gln
    1730                1735                1740                
Gln Lys Gln Pro Val Val Tyr Gly Asp Pro Tyr Gln Ser Arg Leu Asp
1745                1750                1755                1760
Phe Gly Gln Gly Gly Gly Ser Pro Val Cys Leu Ala Gln Val Lys Gln
                1765                1770                1775    
Val Glu Gln Ala Val Gln Thr Ala Pro Tyr Arg Ser Gly Pro Arg Gly
            1780                1785                1790        
Arg Pro Arg Glu Ala Lys Phe Ala Arg Tyr Asn Leu Pro Asn Gln Val
        1795                1800                1805            
Ala Pro Leu Ala Arg Arg Asp Val Leu Ile Thr Gln Met Gly Thr Ala
    1810                1815                1820                
Gln Ser Ile Gly Leu Lys Pro Gly Pro Val Pro Glu Pro Gly Ala Glu
1825                1830                1835                1840
Pro His Arg Ala Thr Pro Ala Glu Leu Arg Ser His Ala Leu Pro Gly
                1845                1850                1855    
Ala Arg Lys Pro His Thr Val Val Val Gln Met Gly Glu Gly Thr Ala
            1860                1865                1870        
Gly Thr Val Thr Thr Leu Leu Pro Glu Glu Pro Ala Gly Ala Leu Asp
        1875                1880                1885            
Leu Thr Gly Met Arg Pro Glu Ser Gln Leu Ala Cys Cys Asp Met Val
    1890                1895                1900                
Tyr Lys Leu Pro Phe Gly Ser Ser Cys Thr Gly Thr Phe His Pro Ala
1905                1910                1915                1920
Pro Ser Val Pro Glu Lys Ser Met Ala Asp Ala Ala Pro Pro Gly Gln
                1925                1930                1935    
Ser Ser Ser Pro Phe Tyr Gly Pro Arg Asp Pro Glu Pro Pro Glu Pro
            1940                1945                1950        
Pro Thr Tyr Arg Ala Gln Gly Val Val Gly Pro Gly Pro His Glu Glu
        1955                1960                1965            
Gln Arg Pro Tyr Pro Gln Gly Leu Pro Gly Arg Leu Tyr Ser Ser Met
    1970                1975                1980                
Ser Asp Thr Asn Leu Ala Glu Ala Gly Leu Asn Tyr His Ala Gln Arg
1985                1990                1995                2000
Ile Gly Gln Leu Phe Gln Gly Pro Gly Arg Asp Ser Ala Met Asp Leu
                2005                2010                2015    
Ser Ser Leu Lys His Ser Tyr Ser Leu Gly Phe Ala Asp Gly Arg Tyr
            2020                2025                2030        
Leu Gly Gln Gly Leu Gln Tyr Gly Ser Val Thr Asp Leu Arg His Pro
        2035                2040                2045            
Thr Asp Leu Leu Ala His Pro Leu Pro Met Arg Arg Tyr Ser Ser Val
    2050                2055                2060                
Ser Asn Ile Tyr Ser Asp His Arg Tyr Gly Pro Arg Gly Asp Ala Val
2065                2070                2075                2080
Gly Phe Gln Glu Ala Ser Leu Ala Gln Tyr Ser Ala Thr Thr Ala Arg
                2085                2090                2095    
Glu Ile Ser Arg Met Cys Ala Ala Leu Asn Ser Met Asp Gln Tyr Gly
            2100                2105                2110        
Gly Arg His Gly Ser Gly Gly Gly Gly Pro Asp Leu Val Gln Tyr Gln
        2115                2120                2125            
Pro Gln His Gly Pro Gly Leu Ser Ala Pro Gln Ser Leu Val Pro Leu
    2130                2135                2140                
Arg Pro Gly Leu Leu Gly Asn Pro Thr Phe Pro Glu Gly His Pro Ser
2145                2150                2155                2160
Pro Gly Asn Leu Ala Gln Tyr Gly Pro Ala Ala Gly Gln Gly Thr Ala
                2165                2170                2175    
Val Arg Gln Leu Leu Pro Ser Thr Ala Thr Val Arg Ala Ala Asp Gly
            2180                2185                2190        
Met Ile Tyr Ser Thr Ile Asn Thr Pro Ile Ala Ala Thr Leu Pro Ile
        2195                2200                2205            
Thr Thr Gln Pro Ala Ser Val Leu Arg Pro Met Val Arg Gly Gly Met
    2210                2215                2220                
Tyr Arg Pro Tyr Ala Ser Gly Gly Ile Thr Ala Val Pro Leu Thr Ser
2225                2230                2235                2240
Leu Thr Arg Val Pro Met Ile Ala Pro Arg Val Pro Leu Gly Pro Thr
                2245                2250                2255    
Gly Leu Tyr Arg Tyr Pro Ala Pro Ser Arg Phe Pro Ile Ala Ser Ser
            2260                2265                2270        
Val Pro Pro Ala Glu Gly Pro Val Tyr Leu Gly Lys Pro Ala Ala Ala
        2275                2280                2285            
Lys Ala Pro Gly Ala Gly Gly Pro Ser Arg Pro Glu Met Pro Val Gly
    2290                2295                2300                
Ala Ala Arg Glu Glu Pro Leu Pro Thr Thr Thr Pro Ala Ala Ile Lys
2305                2310                2315                2320
Glu Ala Ala Gly Ala Pro Ala Pro Ala Pro Leu Ala Gly Gln Lys Pro
                2325                2330                2335    
Pro Ala Asp Ala Ala Pro Gly Gly Gly Ser Gly Ala Leu Ser Arg Pro
            2340                2345                2350        
Gly Phe Glu Lys Glu Glu Ala Ser Gln Glu Glu Arg Gln Arg Lys Gln
        2355                2360                2365            
Gln Glu Gln Leu Leu Gln Leu Glu Arg Glu Arg Val Glu Leu Glu Lys
    2370                2375                2380                
Leu Arg Gln Leu Arg Leu Gln Glu Glu Leu Glu Arg Glu Arg Val Glu
2385                2390                2395                2400
Leu Gln Arg His Arg Glu Glu Glu Gln Leu Leu Val Gln Arg Glu Leu
                2405                2410                2415    
Gln Glu Leu Gln Thr Ile Lys His His Val Leu Gln Gln Gln Gln Glu
            2420                2425                2430        
Glu Arg Gln Ala Gln Phe Ala Leu Gln Arg Glu Gln Leu Ala Gln Gln
        2435                2440                2445            
Arg Leu Gln Leu Glu Gln Ile Gln Gln Leu Gln Gln Gln Leu Gln Gln
    2450                2455                2460                
Gln Leu Glu Glu Gln Lys Gln Arg Gln Lys Ala Pro Phe Pro Ala Ala
2465                2470                2475                2480
Cys Glu Ala Pro Gly Arg Gly Pro Pro Leu Ala Ala Ala Glu Leu Ala
                2485                2490                2495    
Gln Asn Gly Gln Tyr Trp Pro Pro Leu Thr His Ala Ala Phe Ile Ala
            2500                2505                2510        
Met Ala Gly Pro Glu Gly Leu Gly Gln Pro Arg Glu Pro Val Leu His
        2515                2520                2525            
Arg Gly Leu Pro Ser Ser Ala Ser Asp Met Ser Leu Gln Thr Glu Glu
    2530                2535                2540                
Gln Trp Glu Ala Ser Arg Ser Gly Ile Lys Lys Arg His Ser Met Pro
2545                2550                2555                2560
Arg Leu Arg Asp Ala Cys Glu Leu Glu Ser Gly Thr Glu Pro Cys Val
                2565                2570                2575    
Val Arg Arg Ile Ala Asp Ser Ser Val Gln Thr Asp Asp Glu Asp Gly
            2580                2585                2590        
Glu Ser Arg Tyr Leu Leu Ser Arg Arg Arg Arg Ala Arg Arg Ser Ala
        2595                2600                2605            
Asp Cys Ser Val Gln Thr Asp Asp Glu Asp Ser Ala Glu Trp Glu Gln
    2610                2615                2620                
Pro Val Arg Arg Arg Arg Ser Arg Leu Pro Arg His Ser Asp Ser Gly
2625                2630                2635                2640
Ser Asp Ser Lys His Asp Ala Thr Ala Ser Ser Ser Ser Ala Ala Ala
                2645                2650                2655    
Thr Val Arg Ala Met Ser Ser Val Gly Ile Gln Thr Ile Ser Asp Cys
            2660                2665                2670        
Ser Val Gln Thr Glu Pro Asp Gln Leu Pro Arg Val Ser Pro Ala Ile
        2675                2680                2685            
His Ile Thr Ala Ala Thr Asp Pro Lys Val Glu Ile Val Arg Tyr Ile
    2690                2695                2700                
Ser Ala Pro Glu Lys Thr Gly Arg Gly Glu Ser Leu Ala Cys Gln Thr
2705                2710                2715                2720
Glu Pro Asp Gly Gln Ala Gln Gly Val Ala Gly Pro Gln Leu Val Gly
                2725                2730                2735    
Pro Thr Ala Ile Ser Pro Tyr Leu Pro Gly Ile Gln Ile Val Thr Pro
            2740                2745                2750        
Gly Pro Leu Gly Arg Phe Glu Lys Lys Lys Pro Asp Pro Leu Glu Ile
        2755                2760                2765            
Gly Tyr Gln Ala His Leu Pro Pro Glu Ser Leu Ser Gln Leu Val Ser
    2770                2775                2780                
Arg Gln Pro Pro Lys Ser Pro Gln Val Leu Tyr Ser Pro Val Ser Pro
2785                2790                2795                2800
Leu Ser Pro His Arg Leu Leu Asp Thr Ser Phe Ala Ser Ser Glu Arg
                2805                2810                2815    
Leu Asn Lys Ala His Val Ser Pro Gln Lys His Phe Thr Ala Asp Ser
            2820                2825                2830        
Ala Leu Arg Gln Gln Thr Leu Pro Arg Pro Met Lys Thr Leu Gln Arg
        2835                2840                2845            
Ser Leu Ser Asp Pro Lys Pro Leu Ser Pro Thr Ala Glu Glu Ser Ala
    2850                2855                2860                
Lys Glu Arg Phe Ser Leu Tyr Gln His Gln Gly Gly Leu Gly Ser Gln
2865                2870                2875                2880
Val Ser Ala Leu Pro Pro Asn Ser Leu Val Arg Lys Val Lys Arg Thr
                2885                2890                2895    
Leu Pro Ser Pro Pro Pro Glu Glu Ala His Leu Pro Leu Ala Gly Gln
            2900                2905                2910        
Ala Ser Pro Gln Leu Tyr Ala Ala Ser Leu Leu Gln Arg Gly Leu Thr
        2915                2920                2925            
Gly Pro Thr Thr Val Pro Ala Thr Lys Ala Ser Leu Leu Arg Glu Leu
    2930                2935                2940                
Asp Arg Asp Leu Arg Leu Val Glu His Glu Ser Thr Lys Leu Arg Lys
2945                2950                2955                2960
Lys Gln Ala Glu Leu Asp Glu Glu Glu Lys Glu Ile Asp Ala Lys Leu
                2965                2970                2975    
Lys Tyr Leu Glu Leu Gly Ile Thr Gln Arg Lys Glu Ser Leu Ala Lys
            2980                2985                2990        
Thr Gly Val Ala Val Thr Thr His Pro Cys Val Val Leu Ala Ser Ile
        2995                3000                3005            
Val Thr Thr Tyr Arg Thr Val Ser Ser Thr Ser Cys Gly Ser Arg Ala
    3010                3015                3020                
Ala Pro Leu Pro Leu Ala Ser Leu Trp Thr Ser Leu Pro Leu Pro Leu
3025                3030                3035                3040
Leu Leu Pro Pro Pro Leu Val Pro Leu Pro Ser Ser Ser Pro Ala Ser
                3045                3050                3055    
Ser Leu Gln Pro His Ser Ile Leu Gln Ala Val Val Gly Gln Leu Arg
            3060                3065                3070        
Thr Asp Ser Gln Pro Thr Arg Pro Pro Pro Thr Leu Ala Pro Ala Arg
        3075                3080                3085            
Thr Gln Leu Leu Pro Phe Leu Leu Val Pro Val Thr Gln Leu Ser Leu
    3090                3095                3100                
Ala Cys Gln Thr Ser Arg Leu Ser Ala Pro Gln Ala Thr Met Gln Ala
3105                3110                3115                3120
Lys His Pro Cys Gln Pro His Arg Ala Pro Phe Phe Gln Ser Pro Leu
                3125                3130                3135    
Ile Ala Val Pro His Cys Arg Ser His Ala Arg His Arg
            3140                3145                


<210> 2327
<211> 358
<212> PRT
<213> Homo sapiens

<400> 2327
Met Pro Glu Asp Val Arg Glu Lys Lys Glu Asn Leu Leu Leu Asn Ser
 1               5                  10                  15      
Glu Arg Ser Thr Arg Leu Leu Thr Lys Thr Ser His Ser Gln Gly Gly
            20                  25                  30          
Asp Gln Ala Leu Ser Lys Ser Thr Gly Ser Pro Thr Glu Lys Leu Ile
        35                  40                  45              
Glu Lys Arg Gln Gly Ala Lys Thr Val Phe Asn Lys Phe Ser Asn Met
    50                  55                  60                  
Asn Trp Pro Val Asp Ile His Pro Leu Asn Lys Ser Leu Val Lys Asp
65                  70                  75                  80  
Asn Lys Trp Lys Lys Thr Glu Glu Thr Gln Glu Lys Arg Arg Ser Phe
                85                  90                  95      
Leu Gln Glu Phe Cys Lys Lys Tyr Gly Gly Val Ser His His Gln Ser
            100                 105                 110         
His Leu Phe His Thr Val Ser Arg Ile Tyr Val Glu Asp Lys His Lys
        115                 120                 125             
Ile Leu Tyr Cys Glu Val Pro Lys Ala Gly Cys Ser Asn Trp Lys Arg
    130                 135                 140                 
Ile Leu Met Val Leu Asn Gly Leu Ala Ser Ser Ala Tyr Asn Ile Ser
145                 150                 155                 160 
His Asn Ala Val His Tyr Gly Lys His Leu Lys Lys Leu Asp Ser Phe
                165                 170                 175     
Asp Leu Lys Gly Ile Tyr Thr Arg Leu Asn Thr Tyr Thr Lys Ala Val
            180                 185                 190         
Phe Val Arg Asp Pro Met Glu Arg Leu Val Ser Ala Phe Arg Asp Lys
        195                 200                 205             
Phe Glu His Pro Asn Ser Tyr Tyr His Pro Val Phe Gly Lys Ala Ile
    210                 215                 220                 
Ile Lys Lys Tyr Arg Pro Asn Ala Cys Glu Glu Ala Leu Ile Asn Gly
225                 230                 235                 240 
Ser Gly Val Lys Phe Lys Glu Phe Ile His Tyr Leu Leu Asp Ser His
                245                 250                 255     
Arg Pro Val Gly Met Asp Ile His Trp Glu Lys Val Ser Lys Leu Cys
            260                 265                 270         
Tyr Pro Cys Leu Ile Asn Tyr Asp Phe Val Gly Lys Phe Glu Thr Leu
        275                 280                 285             
Glu Glu Asp Ala Asn Tyr Phe Leu Gln Met Ile Gly Ala Pro Lys Glu
    290                 295                 300                 
Leu Lys Phe Pro Asn Phe Lys Asp Arg His Ser Ser Asp Glu Arg Thr
305                 310                 315                 320 
Asn Ala Gln Val Val Arg Gln Tyr Leu Lys Asp Leu Thr Arg Thr Glu
                325                 330                 335     
Arg Gln Leu Ile Tyr Asp Phe Tyr Tyr Leu Asp Tyr Leu Met Phe Asn
            340                 345                 350         
Tyr Thr Thr Pro Phe Leu
        355             


<210> 2328
<211> 457
<212> PRT
<213> Homo sapiens

<400> 2328
Met Thr Ser Met Ala Ser Leu Phe Ser Phe Thr Ser Pro Ala Val Lys
 1               5                  10                  15      
Arg Leu Leu Gly Trp Lys Gln Gly Asp Glu Glu Glu Lys Trp Ala Glu
            20                  25                  30          
Lys Ala Val Asp Ala Leu Val Lys Lys Leu Lys Lys Lys Lys Gly Ala
        35                  40                  45              
Met Glu Glu Leu Glu Lys Ala Leu Ser Ser Pro Gly Gln Pro Ser Lys
    50                  55                  60                  
Cys Val Thr Ile Pro Arg Ser Leu Asp Gly Arg Leu Gln Val Ser His
65                  70                  75                  80  
Arg Lys Gly Leu Pro His Val Ile Tyr Cys Arg Val Trp Arg Trp Pro
                85                  90                  95      
Asp Leu Gln Ser His His Glu Leu Lys Pro Leu Asp Ile Cys Glu Phe
            100                 105                 110         
Pro Phe Gly Ser Lys Gln Lys Glu Val Cys Ile Asn Pro Tyr His Tyr
        115                 120                 125             
Lys Arg Val Glu Ser Pro Val Leu Pro Pro Val Leu Val Pro Arg His
    130                 135                 140                 
Asn Glu Phe Asn Pro Gln His Ser Leu Leu Val Gln Phe Arg Asn Leu
145                 150                 155                 160 
Ser His Asn Glu Pro His Met Pro Gln Asn Ala Thr Phe Pro Asp Ser
                165                 170                 175     
Phe His Gln Pro Asn Asn Thr Pro Phe Pro Leu Ser Pro Asn Ser Pro
            180                 185                 190         
Tyr Pro Pro Ser Pro Ala Ser Ser Thr Tyr Pro Asn Ser Pro Ala Ser
        195                 200                 205             
Ser Gly Pro Gly Ser Pro Phe Gln Leu Pro Ala Asp Thr Pro Pro Pro
    210                 215                 220                 
Ala Tyr Met Pro Pro Asp Asp Gln Met Gly Gln Asp Asn Ser Gln Pro
225                 230                 235                 240 
Met Asp Thr Ser Asn Asn Met Ile Pro Gln Ile Met Pro Ser Ile Ser
                245                 250                 255     
Ser Arg Asp Val Gln Pro Val Ala Tyr Glu Glu Pro Lys His Trp Cys
            260                 265                 270         
Ser Ile Val Tyr Tyr Glu Leu Asn Asn Arg Val Gly Glu Ala Phe His
        275                 280                 285             
Ala Ser Ser Thr Ser Val Leu Val Asp Gly Phe Thr Asp Pro Ser Asn
    290                 295                 300                 
Asn Lys Ser Arg Phe Cys Leu Gly Leu Leu Ser Asn Val Asn Arg Asn
305                 310                 315                 320 
Ser Thr Ile Glu Asn Thr Arg Arg His Ile Gly Lys Gly Val His Leu
                325                 330                 335     
Tyr Tyr Val Gly Gly Glu Val Tyr Ala Glu Cys Leu Ser Asp Ser Ser
            340                 345                 350         
Ile Phe Val Gln Ser Arg Asn Cys Asn Phe His His Gly Phe His Pro
        355                 360                 365             
Thr Thr Val Cys Lys Ile Pro Ser Ser Cys Ser Leu Lys Ile Phe Asn
    370                 375                 380                 
Asn Gln Glu Phe Ala Gln Leu Leu Ala Gln Ser Val Asn His Gly Phe
385                 390                 395                 400 
Glu Ala Val Tyr Glu Leu Thr Lys Met Cys Thr Ile Arg Met Ser Phe
                405                 410                 415     
Val Lys Gly Trp Gly Ala Glu Tyr His Arg Gln Asp Val Thr Ser Thr
            420                 425                 430         
Pro Cys Trp Ile Glu Ile Ile Phe Met Gly Leu Phe Ser Gly Trp Ile
        435                 440                 445             
Lys Ser Leu Leu Arg Trp Ala Pro Leu
    450                 455         


<210> 2329
<211> 155
<212> PRT
<213> Homo sapiens

<400> 2329
Met Asp Phe Asp Ile Ala Gly Pro Ser Ile Arg Gly Ala Leu Val Leu
 1               5                  10                  15      
Gly Tyr Glu Gly Trp Leu Ala Gly Tyr Gln Met Asn Phe Glu Thr Ala
            20                  25                  30          
Lys Ser Arg Val Thr Gln Ser Asn Phe Ala Val Gly Tyr Lys Thr Asp
        35                  40                  45              
Glu Phe Gln Leu His Thr Asn Val Asn Asp Gly Thr Glu Phe Gly Gly
    50                  55                  60                  
Ser Ile Tyr Gln Lys Val Asn Lys Lys Leu Glu Thr Ala Val Asn Leu
65                  70                  75                  80  
Ala Trp Thr Ala Gly Asn Ser Asn Thr Arg Phe Gly Ile Ala Ala Lys
                85                  90                  95      
Tyr Gln Ile Asp Pro Asp Ala Cys Phe Ser Ala Lys Val Asn Asn Ser
            100                 105                 110         
Ser Leu Ile Gly Leu Gly Tyr Thr Gln Thr Leu Lys Pro Gly Ile Lys
        115                 120                 125             
Leu Thr Leu Ser Ala Leu Leu Asp Gly Lys Asn Val Asn Ala Gly Gly
    130                 135                 140                 
His Lys Leu Gly Leu Gly Leu Glu Phe Gln Ala
145                 150                 155 


<210> 2330
<211> 725
<212> PRT
<213> Homo sapiens

<400> 2330
Met Glu Val Gly Phe Gln Lys Gly Thr Arg Gln Leu Leu Gly Ser Arg
 1               5                  10                  15      
Thr Gln Leu Glu Leu Val Leu Ala Gly Ala Ser Leu Leu Leu Ala Ala
            20                  25                  30          
Leu Leu Leu Gly Cys Leu Val Ala Leu Gly Val Gln Tyr His Arg Asp
        35                  40                  45              
Pro Ser His Ser Thr Cys Leu Thr Glu Ala Cys Ile Arg Val Ala Gly
    50                  55                  60                  
Lys Ile Leu Glu Ser Leu Asp Arg Gly Val Ser Pro Cys Glu Asp Phe
65                  70                  75                  80  
Tyr Gln Phe Ser Cys Gly Gly Trp Ile Arg Arg Asn Pro Leu Pro Asp
                85                  90                  95      
Gly Arg Ser Arg Trp Asn Thr Phe Asn Ser Leu Trp Asp Gln Asn Gln
            100                 105                 110         
Ala Ile Leu Lys His Leu Leu Glu Asn Thr Thr Phe Asn Ser Ser Ser
        115                 120                 125             
Glu Ala Glu Gln Lys Thr Gln Arg Phe Tyr Leu Ser Cys Leu Gln Val
    130                 135                 140                 
Glu Arg Ile Glu Glu Leu Gly Ala Gln Pro Leu Arg Asp Leu Ile Glu
145                 150                 155                 160 
Lys Ile Gly Gly Trp Asn Ile Thr Gly Pro Trp Asp Gln Asp Asn Phe
                165                 170                 175     
Met Glu Val Leu Lys Ala Val Ala Gly Thr Tyr Arg Ala Thr Pro Phe
            180                 185                 190         
Phe Thr Val Tyr Ile Ser Ala Asp Ser Lys Ser Ser Asn Ser Asn Val
        195                 200                 205             
Ile Gln Val Asp Gln Ser Gly Leu Phe Leu Pro Ser Arg Asp Tyr Tyr
    210                 215                 220                 
Leu Asn Arg Thr Ala Asn Glu Lys Val Leu Thr Ala Tyr Leu Asp Tyr
225                 230                 235                 240 
Met Glu Glu Leu Gly Met Leu Leu Gly Gly Arg Pro Thr Ser Thr Arg
                245                 250                 255     
Glu Gln Met Gln Gln Val Leu Glu Leu Glu Ile Gln Leu Ala Asn Ile
            260                 265                 270         
Thr Val Pro Gln Asp Gln Arg Arg Asp Glu Glu Lys Ile Tyr His Lys
        275                 280                 285             
Met Ser Ile Ser Glu Leu Gln Ala Leu Ala Pro Ser Met Asp Trp Leu
    290                 295                 300                 
Glu Phe Leu Ser Phe Leu Leu Ser Pro Leu Glu Leu Ser Asp Ser Glu
305                 310                 315                 320 
Pro Val Val Val Tyr Gly Met Asp Tyr Leu Gln Gln Val Ser Glu Leu
                325                 330                 335     
Ile Asn Arg Thr Glu Pro Ser Ile Leu Asn Asn Tyr Leu Ile Trp Asn
            340                 345                 350         
Leu Val Gln Lys Thr Thr Ser Ser Leu Asp Arg Arg Phe Glu Ser Ala
        355                 360                 365             
Gln Glu Lys Leu Leu Glu Thr Leu Tyr Gly Thr Lys Lys Ser Cys Val
    370                 375                 380                 
Pro Arg Trp Gln Thr Cys Ile Ser Asn Thr Asp Asp Ala Leu Gly Phe
385                 390                 395                 400 
Ala Leu Gly Ser Leu Phe Val Lys Ala Thr Phe Asp Arg Gln Ser Lys
                405                 410                 415     
Glu Ile Ala Glu Gly Met Ile Ser Glu Ile Arg Thr Ala Phe Glu Glu
            420                 425                 430         
Ala Leu Gly Gln Leu Val Trp Met Asp Glu Lys Thr Arg Gln Ala Ala
        435                 440                 445             
Lys Glu Lys Ala Asp Ala Ile Tyr Asp Met Ile Gly Phe Pro Asp Phe
    450                 455                 460                 
Ile Leu Glu Pro Lys Glu Leu Asp Asp Val Tyr Asp Gly Tyr Glu Ile
465                 470                 475                 480 
Ser Glu Asp Ser Phe Phe Gln Asn Met Leu Asn Leu Tyr Asn Phe Ser
                485                 490                 495     
Ala Lys Val Met Ala Asp Gln Leu Arg Lys Pro Pro Ser Arg Asp Gln
            500                 505                 510         
Trp Ser Met Thr Pro Gln Thr Val Asn Ala Tyr Tyr Leu Pro Thr Lys
        515                 520                 525             
Asn Glu Ile Val Phe Pro Ala Gly Ile Leu Gln Ala Pro Phe Tyr Ala
    530                 535                 540                 
Arg Asn His Pro Lys Ala Leu Asn Phe Gly Gly Ile Gly Val Val Met
545                 550                 555                 560 
Gly His Glu Leu Thr His Ala Phe Asp Asp Gln Gly Arg Glu Tyr Asp
                565                 570                 575     
Lys Glu Gly Asn Leu Arg Pro Trp Trp Gln Asn Glu Ser Leu Ala Ala
            580                 585                 590         
Phe Arg Asn His Thr Ala Cys Met Glu Glu Gln Tyr Asn Gln Tyr Gln
        595                 600                 605             
Val Asn Gly Glu Arg Leu Asn Gly Arg Gln Thr Leu Gly Glu Asn Ile
    610                 615                 620                 
Ala Asp Asn Gly Gly Leu Lys Ala Ala Tyr Asn Ala Tyr Lys Ala Trp
625                 630                 635                 640 
Leu Arg Lys His Gly Glu Glu Gln Gln Leu Pro Ala Val Gly Leu Thr
                645                 650                 655     
Asn His Gln Leu Phe Phe Val Gly Phe Ala Gln Val Trp Cys Ser Val
            660                 665                 670         
Arg Thr Pro Glu Ser Ser His Glu Gly Leu Val Thr Asp Pro His Ser
        675                 680                 685             
Pro Ala Arg Phe Arg Val Leu Gly Thr Leu Ser Asn Ser Arg Asp Phe
    690                 695                 700                 
Leu Arg His Phe Gly Cys Pro Val Gly Ser Pro Met Asn Pro Gly Gln
705                 710                 715                 720 
Leu Cys Glu Val Trp
                725 


<210> 2331
<211> 177
<212> PRT
<213> Homo sapiens

<400> 2331
Met Ser Gly Ala Leu Asp Val Leu Gln Met Lys Glu Glu Asp Val Leu
 1               5                  10                  15      
Lys Phe Leu Ala Ala Gly Thr His Leu Gly Gly Thr Asn Leu Asp Phe
            20                  25                  30          
Gln Met Glu Gln Tyr Ile Tyr Lys Arg Lys Ser Asp Gly Ile Tyr Ile
        35                  40                  45              
Ile Asn Leu Lys Arg Thr Trp Glu Lys Leu Leu Leu Ala Ala Arg Ala
    50                  55                  60                  
Ile Val Ala Ile Glu Asn Pro Ala Asp Val Ser Val Ile Ser Ser Arg
65                  70                  75                  80  
Asn Thr Gly Gln Val Cys Gly Thr Val Arg Ala Val Leu Lys Phe Ala
                85                  90                  95      
Ala Ala Thr Gly Ala Thr Pro Ile Ala Gly Arg Phe Thr Pro Gly Thr
            100                 105                 110         
Phe Thr Asn Gln Ile Gln Ala Ala Phe Arg Glu Pro Arg Leu Leu Val
        115                 120                 125             
Val Thr Asp Pro Gly Leu Thr Thr Ser Leu Ser Arg Arg His Leu Met
    130                 135                 140                 
Leu Thr Tyr Leu Pro Leu Arg Cys Val Thr Gln Ile Leu Leu Cys Ala
145                 150                 155                 160 
Met Trp Thr Leu Pro Ser His Ala Thr Thr Arg Glu Leu Thr Gln Trp
                165                 170                 175     
Val
    


<210> 2332
<211> 742
<212> PRT
<213> Homo sapiens

<400> 2332
Met Glu Glu Gly Phe Arg Asp Arg Ala Ala Phe Ile Arg Gly Ala Lys
 1               5                  10                  15      
Asp Ile Ala Lys Glu Val Lys Lys His Ala Ala Lys Lys Val Val Lys
            20                  25                  30          
Gly Leu Asp Arg Val Gln Asp Glu Tyr Ser Arg Arg Ser Tyr Ser Arg
        35                  40                  45              
Phe Glu Glu Glu Asp Asp Asp Asp Asp Phe Pro Ala Pro Ser Asp Gly
    50                  55                  60                  
Tyr Tyr Arg Gly Glu Gly Thr His Asp Glu Glu Glu Gly Gly Ala Ser
65                  70                  75                  80  
Ser Asp Ala Thr Glu Gly His Asp Glu Asp Asp Glu Ile Tyr Glu Gly
                85                  90                  95      
Glu Tyr Gln Gly Ile Pro Arg Ala Glu Ser Gly Gly Lys Gly Glu Arg
            100                 105                 110         
Met Ala Asp Gly Ala Pro Leu Ala Gly Val Arg Gly Gly Leu Ser Asp
        115                 120                 125             
Gly Glu Gly Pro Pro Gly Gly Arg Gly Glu Ala Gln Arg Arg Lys Glu
    130                 135                 140                 
Arg Glu Glu Leu Ala Gln Gln Tyr Glu Ala Ile Leu Arg Glu Cys Gly
145                 150                 155                 160 
His Gly Arg Phe Gln Trp Thr Leu Tyr Phe Val Leu Gly Leu Ala Leu
                165                 170                 175     
Met Ala Asp Gly Val Glu Val Phe Val Val Gly Phe Val Leu Pro Ser
            180                 185                 190         
Ala Glu Lys Asp Met Cys Leu Ser Asp Ser Asn Lys Gly Met Leu Gly
        195                 200                 205             
Leu Ile Val Tyr Leu Gly Met Met Val Gly Ala Phe Leu Trp Gly Gly
    210                 215                 220                 
Leu Ala Asp Arg Leu Gly Arg Arg Gln Cys Leu Leu Ile Ser Leu Ser
225                 230                 235                 240 
Val Asn Ser Val Phe Ala Phe Phe Ser Ser Phe Val Gln Gly Tyr Gly
                245                 250                 255     
Thr Phe Leu Phe Cys Arg Leu Leu Ser Gly Val Gly Ile Gly Gly Ser
            260                 265                 270         
Ile Pro Ile Val Phe Ser Tyr Phe Ser Glu Phe Leu Ala Gln Glu Lys
        275                 280                 285             
Arg Gly Glu His Leu Ser Trp Leu Cys Met Phe Trp Met Ile Gly Gly
    290                 295                 300                 
Val Tyr Ala Ala Ala Met Ala Trp Ala Ile Ile Pro His Tyr Gly Trp
305                 310                 315                 320 
Ser Phe Gln Met Gly Ser Ala Tyr Gln Phe His Ser Trp Arg Val Phe
                325                 330                 335     
Val Leu Val Cys Ala Phe Pro Ser Val Phe Ala Ile Gly Ala Leu Thr
            340                 345                 350         
Thr Gln Pro Glu Ser Pro Arg Phe Phe Leu Glu Asn Gly Lys His Asp
        355                 360                 365             
Glu Ala Trp Met Val Leu Lys Gln Val His Asp Thr Asn Met Arg Ala
    370                 375                 380                 
Lys Gly His Pro Glu Arg Val Phe Ser Val Thr His Ile Lys Thr Ile
385                 390                 395                 400 
His Gln Glu Asp Glu Leu Ile Glu Ile Gln Ser Asp Thr Gly Thr Trp
                405                 410                 415     
Tyr Gln Arg Trp Gly Val Arg Ala Leu Ser Leu Gly Gly Gln Val Trp
            420                 425                 430         
Gly Asn Phe Leu Ser Cys Phe Gly Pro Glu Tyr Arg Arg Ile Thr Leu
        435                 440                 445             
Met Met Met Gly Val Trp Phe Thr Met Ser Phe Ser Tyr Tyr Gly Leu
    450                 455                 460                 
Thr Val Trp Phe Pro Asp Met Ile Arg His Leu Gln Ala Val Asp Tyr
465                 470                 475                 480 
Ala Ser Arg Thr Lys Val Phe Pro Gly Glu Arg Val Glu His Val Thr
                485                 490                 495     
Phe Asn Phe Thr Leu Glu Asn Gln Ile His Arg Gly Gly Gln Tyr Phe
            500                 505                 510         
Asn Asp Lys Phe Ile Gly Leu Arg Leu Lys Ser Val Ser Phe Glu Asp
        515                 520                 525             
Ser Leu Phe Glu Glu Cys Tyr Phe Glu Asp Val Thr Ser Ser Asn Thr
    530                 535                 540                 
Phe Phe Arg Asn Cys Thr Phe Ile Asn Thr Val Phe Tyr Asn Thr Asp
545                 550                 555                 560 
Leu Phe Glu Tyr Lys Phe Val Asn Ser Arg Leu Ile Asn Ser Thr Phe
                565                 570                 575     
Leu His Asn Lys Glu Gly Cys Pro Leu Asp Val Thr Gly Thr Gly Glu
            580                 585                 590         
Gly Ala Tyr Met Val Tyr Phe Val Ser Phe Leu Gly Thr Leu Ala Val
        595                 600                 605             
Leu Pro Gly Asn Ile Val Ser Ala Leu Leu Met Asp Lys Ile Gly Arg
    610                 615                 620                 
Leu Arg Met Leu Ala Gly Ser Ser Val Met Ser Cys Val Ser Cys Phe
625                 630                 635                 640 
Phe Leu Ser Phe Gly Asn Ser Glu Ser Ala Met Ile Ala Leu Leu Cys
                645                 650                 655     
Leu Phe Gly Gly Val Ser Ile Ala Ser Trp Asn Ala Leu Asp Val Leu
            660                 665                 670         
Thr Val Glu Leu Tyr Pro Ser Asp Lys Arg Thr Thr Ala Phe Gly Phe
        675                 680                 685             
Leu Asn Ala Leu Cys Lys Leu Ala Ala Val Leu Gly Ile Ser Ile Phe
    690                 695                 700                 
Thr Ser Phe Val Gly Ile Thr Lys Ala Ala Pro Ile Leu Phe Ala Ser
705                 710                 715                 720 
Ala Ala Leu Ala Leu Gly Ser Ser Leu Ala Leu Lys Leu Pro Glu Thr
                725                 730                 735     
Arg Gly Gln Val Leu Gln
            740         


<210> 2333
<211> 960
<212> PRT
<213> Homo sapiens

<400> 2333
Met Trp Arg Leu Arg Arg Ala Ala Val Ala Cys Glu Val Cys Gln Ser
 1               5                  10                  15      
Leu Val Lys His Ser Ser Gly Ile Lys Gly Ser Leu Pro Leu Gln Lys
            20                  25                  30          
Leu His Leu Val Ser Arg Ser Ile Tyr His Ser His His Pro Thr Leu
        35                  40                  45              
Lys Leu Gln Arg Pro Gln Leu Arg Thr Ser Phe Gln Gln Phe Ser Ser
    50                  55                  60                  
Leu Thr Asn Leu Pro Leu Arg Lys Leu Lys Phe Ser Pro Ile Lys Tyr
65                  70                  75                  80  
Gly Tyr Gln Pro Arg Arg Asn Phe Trp Pro Ala Arg Leu Ala Thr Arg
                85                  90                  95      
Leu Leu Lys Leu Arg Tyr Leu Ile Leu Gly Ser Ala Val Gly Gly Gly
            100                 105                 110         
Tyr Thr Ala Lys Lys Thr Phe Asp Gln Trp Lys Asp Met Ile Pro Asp
        115                 120                 125             
Leu Ser Glu Tyr Lys Trp Ile Val Pro Asp Ile Val Trp Glu Ile Asp
    130                 135                 140                 
Glu Tyr Ile Asp Phe Glu Lys Ile Arg Lys Ala Leu Pro Ser Ser Glu
145                 150                 155                 160 
Asp Leu Val Lys Leu Ala Pro Asp Phe Asp Lys Ile Val Glu Ser Leu
                165                 170                 175     
Ser Leu Leu Lys Asp Phe Phe Thr Ser Gly Ser Pro Glu Glu Thr Ala
            180                 185                 190         
Phe Arg Ala Thr Asp Arg Gly Ser Glu Ser Asp Lys His Phe Arg Lys
        195                 200                 205             
Val Ser Asp Lys Glu Lys Ile Asp Gln Leu Gln Glu Glu Leu Leu His
    210                 215                 220                 
Thr Gln Leu Lys Tyr Gln Arg Ile Leu Glu Arg Leu Glu Lys Glu Asn
225                 230                 235                 240 
Lys Glu Leu Arg Lys Leu Val Leu Gln Lys Asp Asp Lys Gly Ile His
                245                 250                 255     
His Arg Lys Leu Lys Lys Ser Leu Ile Asp Met Tyr Ser Glu Val Leu
            260                 265                 270         
Asp Val Leu Ser Asp Tyr Asp Ala Ser Tyr Asn Thr Gln Asp His Leu
        275                 280                 285             
Pro Arg Val Val Val Val Gly Asp Gln Ser Ala Gly Lys Thr Ser Val
    290                 295                 300                 
Leu Glu Met Ile Ala Gln Ala Arg Ile Phe Pro Arg Gly Ser Gly Glu
305                 310                 315                 320 
Met Met Thr Arg Ser Pro Val Lys Val Thr Leu Ser Glu Gly Pro His
                325                 330                 335     
His Val Ala Leu Phe Lys Asp Ser Ser Arg Glu Phe Asp Leu Thr Lys
            340                 345                 350         
Glu Glu Asp Leu Ala Ala Leu Arg His Glu Ile Glu Leu Arg Met Arg
        355                 360                 365             
Lys Asn Val Lys Glu Gly Cys Thr Val Ser Pro Glu Thr Ile Ser Leu
    370                 375                 380                 
Asn Val Lys Gly Pro Gly Leu Gln Arg Met Val Leu Val Asp Leu Pro
385                 390                 395                 400 
Gly Val Ile Asn Thr Val Thr Ser Gly Met Ala Pro Asp Thr Lys Glu
                405                 410                 415     
Thr Ile Phe Ser Ile Ser Lys Ala Tyr Met Gln Asn Pro Asn Ala Ile
            420                 425                 430         
Ile Leu Cys Ile Gln Asp Gly Ser Val Asp Ala Glu Arg Ser Ile Val
        435                 440                 445             
Thr Asp Leu Val Ser Gln Met Asp Pro His Gly Arg Arg Thr Ile Phe
    450                 455                 460                 
Val Leu Thr Lys Val Asp Leu Ala Glu Lys Asn Val Ala Ser Pro Ser
465                 470                 475                 480 
Arg Ile Gln Gln Ile Ile Glu Gly Lys Leu Phe Pro Met Lys Ala Leu
                485                 490                 495     
Gly Tyr Phe Ala Val Val Thr Gly Lys Gly Asn Ser Ser Glu Ser Ile
            500                 505                 510         
Glu Ala Ile Arg Glu Tyr Glu Glu Glu Phe Phe Gln Asn Ser Lys Leu
        515                 520                 525             
Leu Lys Thr Ser Met Leu Lys Ala His Gln Val Thr Thr Arg Asn Leu
    530                 535                 540                 
Ser Leu Ala Val Ser Asp Cys Phe Trp Lys Met Val Arg Glu Ser Val
545                 550                 555                 560 
Glu Gln Gln Ala Asp Ser Phe Lys Ala Thr Arg Phe Asn Leu Glu Thr
                565                 570                 575     
Glu Trp Lys Asn Asn Tyr Pro Arg Leu Arg Glu Leu Asp Arg Asn Glu
            580                 585                 590         
Leu Phe Glu Lys Ala Lys Asn Glu Ile Leu Asp Glu Val Ile Ser Leu
        595                 600                 605             
Ser Gln Val Thr Pro Lys His Trp Glu Glu Ile Leu Gln Gln Ser Leu
    610                 615                 620                 
Trp Glu Arg Val Ser Thr His Val Ile Glu Asn Ile Tyr Leu Pro Ala
625                 630                 635                 640 
Ala Gln Thr Met Asn Ser Gly Thr Phe Asn Thr Thr Val Asp Ile Lys
                645                 650                 655     
Leu Lys Gln Trp Thr Asp Lys Gln Leu Pro Asn Lys Ala Val Glu Val
            660                 665                 670         
Ala Trp Glu Thr Leu Gln Glu Glu Phe Ser Arg Phe Met Thr Glu Pro
        675                 680                 685             
Lys Gly Lys Glu His Asp Asp Ile Phe Asp Lys Leu Lys Glu Ala Val
    690                 695                 700                 
Lys Glu Glu Ser Ile Lys Arg His Lys Trp Asn Asp Phe Ala Glu Asp
705                 710                 715                 720 
Ser Leu Arg Val Ile Gln His Asn Ala Leu Glu Asp Arg Ser Ile Ser
                725                 730                 735     
Asp Lys Gln Gln Trp Asp Ala Ala Ile Tyr Phe Met Glu Glu Ala Leu
            740                 745                 750         
Gln Ala Arg Leu Lys Asp Thr Glu Asn Ala Ile Glu Asn Met Val Gly
        755                 760                 765             
Pro Asp Trp Lys Lys Arg Trp Leu Tyr Trp Lys Asn Arg Thr Gln Glu
    770                 775                 780                 
Gln Cys Val His Asn Glu Thr Lys Asn Glu Leu Glu Lys Met Leu Lys
785                 790                 795                 800 
Cys Asn Glu Glu His Pro Ala Tyr Leu Ala Ser Asp Glu Ile Thr Thr
                805                 810                 815     
Val Arg Lys Asn Leu Glu Ser Arg Gly Val Glu Val Asp Pro Ser Leu
            820                 825                 830         
Ile Lys Asp Thr Trp His Gln Val Tyr Arg Arg His Phe Leu Lys Thr
        835                 840                 845             
Ala Leu Asn His Cys Asn Leu Cys Arg Arg Gly Phe Tyr Tyr Tyr Gln
    850                 855                 860                 
Arg His Phe Val Asp Ser Glu Leu Glu Cys Asn Asp Val Val Leu Phe
865                 870                 875                 880 
Trp Arg Ile Gln Arg Met Leu Ala Ile Thr Ala Asn Thr Leu Arg Gln
                885                 890                 895     
Gln Leu Thr Asn Thr Glu Val Arg Arg Leu Glu Lys Asn Val Lys Glu
            900                 905                 910         
Val Leu Glu Asp Phe Ala Glu Asp Gly Glu Lys Lys Ile Lys Leu Leu
        915                 920                 925             
Thr Gly Lys Arg Val Gln Leu Ala Glu Asp Leu Lys Lys Val Arg Glu
    930                 935                 940                 
Ile Gln Glu Lys Leu Asp Ala Phe Ile Glu Ala Leu His Gln Glu Lys
945                 950                 955                 960 


<210> 2334
<211> 1179
<212> PRT
<213> Homo sapiens

<400> 2334
Met Ile Ile Ser Pro Glu Arg Leu Asp Pro Phe Ala Asp Gly Gly Lys
 1               5                  10                  15      
Thr Pro Asp Pro Lys Met Asn Ala Arg Thr Tyr Met Asp Val Met Arg
            20                  25                  30          
Glu Gln His Leu Thr Lys Glu Glu Arg Glu Ile Arg Gln Gln Leu Ala
        35                  40                  45              
Glu Lys Ala Lys Ala Gly Glu Leu Lys Val Val Asn Gly Ala Ala Ala
    50                  55                  60                  
Ser Gln Pro Pro Ser Lys Arg Lys Arg Arg Trp Asp Gln Thr Ala Asp
65                  70                  75                  80  
Gln Thr Pro Gly Ala Thr Pro Lys Lys Leu Ser Ser Trp Asp Gln Ala
                85                  90                  95      
Glu Thr Pro Gly His Thr Pro Ser Leu Arg Trp Asp Glu Thr Pro Gly
            100                 105                 110         
Arg Ala Lys Gly Ser Glu Thr Pro Gly Ala Thr Pro Gly Ser Lys Ile
        115                 120                 125             
Trp Asp Pro Thr Pro Ser His Thr Pro Ala Gly Ala Ala Thr Pro Gly
    130                 135                 140                 
Arg Gly Asp Thr Pro Gly His Ala Thr Pro Gly His Gly Gly Ala Thr
145                 150                 155                 160 
Ser Ser Ala Arg Lys Asn Arg Trp Asp Glu Thr Pro Lys Thr Glu Arg
                165                 170                 175     
Asp Thr Pro Gly His Gly Ser Gly Trp Ala Glu Thr Pro Arg Thr Asp
            180                 185                 190         
Arg Gly Gly Asp Ser Ile Gly Glu Thr Pro Thr Pro Gly Ala Ser Lys
        195                 200                 205             
Arg Lys Ser Arg Trp Asp Glu Thr Pro Ala Ser Gln Met Gly Gly Ser
    210                 215                 220                 
Thr Pro Val Leu Thr Pro Gly Lys Thr Pro Ile Gly Thr Pro Ala Met
225                 230                 235                 240 
Asn Met Ala Thr Pro Thr Pro Gly His Ile Met Ser Met Thr Pro Glu
                245                 250                 255     
Gln Leu Gln Ala Trp Arg Trp Glu Arg Glu Ile Asp Glu Arg Asn Arg
            260                 265                 270         
Pro Leu Ser Asp Glu Glu Leu Asp Ala Met Phe Pro Glu Gly Tyr Lys
        275                 280                 285             
Val Leu Pro Pro Pro Ala Gly Tyr Val Pro Ile Arg Thr Pro Ala Arg
    290                 295                 300                 
Lys Leu Thr Ala Thr Pro Thr Pro Leu Gly Gly Met Thr Gly Phe His
305                 310                 315                 320 
Met Gln Thr Glu Asp Arg Thr Met Lys Ser Val Asn Asp Gln Pro Ser
                325                 330                 335     
Gly Asn Leu Pro Phe Leu Lys Pro Asp Asp Ile Gln Tyr Phe Asp Lys
            340                 345                 350         
Leu Leu Val Asp Val Asp Glu Ser Thr Leu Ser Pro Glu Glu Gln Lys
        355                 360                 365             
Glu Arg Lys Ile Met Lys Leu Leu Leu Lys Ile Lys Asn Gly Thr Pro
    370                 375                 380                 
Pro Met Arg Lys Ala Ala Leu Arg Gln Ile Thr Asp Lys Ala Arg Glu
385                 390                 395                 400 
Phe Gly Ala Gly Pro Leu Phe Asn Gln Ile Leu Pro Leu Leu Met Ser
                405                 410                 415     
Pro Thr Leu Glu Asp Gln Glu Arg His Leu Leu Val Lys Val Ile Asp
            420                 425                 430         
Arg Ile Leu Tyr Lys Leu Asp Asp Leu Val Arg Pro Tyr Val His Lys
        435                 440                 445             
Ile Leu Val Val Ile Glu Pro Leu Leu Ile Asp Glu Asp Tyr Tyr Ala
    450                 455                 460                 
Arg Val Glu Gly Arg Glu Ile Ile Ser Asn Leu Ala Lys Ala Ala Gly
465                 470                 475                 480 
Leu Ala Thr Met Ile Ser Thr Met Arg Pro Asp Ile Asp Asn Met Asp
                485                 490                 495     
Glu Tyr Val Arg Asn Thr Thr Ala Arg Ala Phe Ala Val Val Ala Ser
            500                 505                 510         
Ala Leu Gly Ile Pro Ser Leu Leu Pro Phe Leu Lys Ala Val Cys Lys
        515                 520                 525             
Ser Lys Lys Ser Trp Gln Ala Arg His Thr Gly Ile Lys Ile Val Gln
    530                 535                 540                 
Gln Ile Ala Ile Leu Met Gly Cys Ala Ile Leu Pro His Leu Arg Ser
545                 550                 555                 560 
Leu Val Glu Ile Ile Glu His Gly Leu Val Asp Glu Gln Gln Lys Val
                565                 570                 575     
Arg Thr Ile Ser Ala Leu Ala Ile Ala Ala Leu Ala Glu Ala Ala Thr
            580                 585                 590         
Pro Tyr Gly Ile Glu Ser Phe Asp Ser Val Leu Lys Pro Leu Trp Lys
        595                 600                 605             
Gly Ile Arg Gln His Arg Gly Lys Gly Leu Ala Ala Phe Leu Lys Ala
    610                 615                 620                 
Ile Gly Tyr Leu Ile Pro Leu Met Asp Ala Glu Tyr Ala Asn Tyr Tyr
625                 630                 635                 640 
Thr Arg Glu Val Met Leu Ile Leu Ile Arg Glu Phe Gln Ser Pro Asp
                645                 650                 655     
Glu Glu Met Lys Lys Ile Val Leu Lys Val Val Lys Gln Cys Cys Gly
            660                 665                 670         
Thr Asp Gly Val Glu Ala Asn Tyr Ile Lys Thr Glu Ile Leu Pro Pro
        675                 680                 685             
Phe Phe Lys His Phe Trp Gln His Arg Met Ala Leu Asp Arg Arg Asn
    690                 695                 700                 
Tyr Arg Gln Leu Val Asp Thr Thr Val Glu Leu Ala Asn Lys Val Gly
705                 710                 715                 720 
Ala Ala Glu Ile Ile Ser Arg Ile Val Asp Asp Leu Lys Asp Glu Ala
                725                 730                 735     
Glu Gln Tyr Arg Lys Met Val Met Glu Thr Ile Glu Lys Ile Met Gly
            740                 745                 750         
Asn Leu Gly Ala Ala Asp Ile Asp His Lys Leu Glu Glu Gln Leu Ile
        755                 760                 765             
Asp Gly Ile Leu Tyr Ala Phe Gln Glu Gln Thr Thr Glu Asp Ser Val
    770                 775                 780                 
Met Leu Asn Gly Phe Gly Thr Val Val Asn Ala Leu Gly Lys Arg Val
785                 790                 795                 800 
Lys Pro Tyr Leu Pro Gln Ile Cys Gly Thr Val Leu Trp Arg Leu Asn
                805                 810                 815     
Asn Lys Ser Ala Lys Val Arg Gln Gln Ala Ala Asp Leu Ile Ser Arg
            820                 825                 830         
Thr Ala Val Val Met Lys Thr Cys Gln Glu Glu Lys Leu Met Gly His
        835                 840                 845             
Leu Gly Val Val Leu Tyr Glu Tyr Leu Gly Glu Glu Tyr Pro Glu Val
    850                 855                 860                 
Leu Gly Ser Ile Leu Gly Ala Leu Lys Ala Ile Val Asn Val Ile Gly
865                 870                 875                 880 
Met His Lys Met Thr Pro Pro Ile Lys Asp Leu Leu Pro Arg Leu Thr
                885                 890                 895     
Pro Ile Leu Lys Asn Arg His Glu Lys Val Gln Glu Asn Cys Ile Asp
            900                 905                 910         
Leu Val Gly Arg Ile Ala Asp Arg Gly Ala Glu Tyr Val Ser Ala Arg
        915                 920                 925             
Glu Trp Met Arg Ile Cys Phe Glu Leu Leu Glu Leu Leu Lys Ala His
    930                 935                 940                 
Lys Lys Ala Ile Arg Arg Ala Thr Val Asn Thr Phe Gly Tyr Ile Ala
945                 950                 955                 960 
Lys Ala Ile Gly Pro His Asp Val Leu Ala Thr Leu Leu Asn Asn Leu
                965                 970                 975     
Lys Val Gln Glu Arg Gln Asn Arg Val Cys Thr Thr Val Ala Ile Ala
            980                 985                 990         
Ile Val Ala Glu Thr Cys Ser Pro Phe Thr Val Leu Pro Ala Leu Met
        995                 1000                1005            
Asn Glu Tyr Arg Val Pro Glu Leu Asn Val Gln Asn Gly Val Leu Lys
    1010                1015                1020                
Ser Leu Ser Phe Leu Phe Glu Tyr Ile Gly Glu Met Gly Lys Asp Tyr
1025                1030                1035                1040
Ile Tyr Ala Val Thr Pro Leu Leu Glu Asp Ala Leu Met Asp Arg Asp
                1045                1050                1055    
Leu Val His Arg Gln Thr Ala Ser Ala Val Val Gln His Met Ser Leu
            1060                1065                1070        
Gly Val Tyr Gly Phe Gly Cys Glu Asp Ser Leu Asn His Leu Leu Asn
        1075                1080                1085            
Tyr Val Trp Pro Asn Val Phe Glu Thr Ser Pro His Val Ile Gln Ala
    1090                1095                1100                
Val Met Gly Ala Leu Glu Gly Leu Arg Val Ala Ile Gly Pro Cys Arg
1105                1110                1115                1120
Met Leu Gln Tyr Cys Leu Gln Gly Leu Phe His Pro Ala Arg Lys Val
                1125                1130                1135    
Arg Asp Val Tyr Trp Lys Ile Tyr Asn Ser Ile Tyr Ile Gly Ser Gln
            1140                1145                1150        
Asp Ala Leu Ile Ala His Tyr Pro Arg Ile Tyr Asn Asp Asp Lys Asn
        1155                1160                1165            
Thr Tyr Ile Arg Tyr Glu Leu Asp Tyr Ile Leu
    1170                1175                


<210> 2335
<211> 806
<212> PRT
<213> Homo sapiens

<400> 2335
Met Ile Lys Ser Val Lys Arg Ala Tyr His Arg Leu Cys Leu His Cys
 1               5                  10                  15      
Ser Val Asp Gln Glu Gly Lys Ser Val Leu Ser Glu Lys Phe Ile Leu
            20                  25                  30          
Lys Val Arg Pro Ala Phe Lys Ala Val Pro Val Val Ser Val Ser Lys
        35                  40                  45              
Ala Ser Tyr Leu Leu Arg Glu Gly Glu Glu Phe Thr Val Thr Cys Thr
    50                  55                  60                  
Ile Lys Asp Val Ser Ser Ser Val Tyr Ser Thr Trp Lys Arg Glu Asn
65                  70                  75                  80  
Ser Gln Thr Lys Leu Gln Glu Lys Tyr Asn Ser Trp His His Gly Asp
                85                  90                  95      
Phe Asn Tyr Glu Arg Gln Ala Thr Leu Thr Ile Ser Ser Ala Arg Val
            100                 105                 110         
Asn Asp Ser Gly Val Phe Met Cys Tyr Ala Asn Asn Thr Phe Gly Ser
        115                 120                 125             
Ala Asn Val Thr Thr Thr Leu Glu Val Val Asp Lys Gly Phe Ile Asn
    130                 135                 140                 
Ile Phe Pro Met Ile Asn Thr Thr Val Phe Val Asn Asp Gly Glu Asn
145                 150                 155                 160 
Val Asp Leu Ile Val Glu Tyr Glu Ala Phe Pro Lys Pro Glu His Gln
                165                 170                 175     
Gln Trp Ile Tyr Met Asn Arg Thr Phe Thr Asp Lys Trp Glu Asp Tyr
            180                 185                 190         
Pro Lys Ser Glu Asn Glu Ser Asn Ile Arg Tyr Val Ser Glu Leu His
        195                 200                 205             
Leu Thr Arg Leu Lys Gly Thr Glu Gly Gly Thr Tyr Thr Phe Leu Val
    210                 215                 220                 
Ser Asn Ser Asp Val Asn Ala Ala Ile Ala Phe Asn Val Tyr Val Asn
225                 230                 235                 240 
Thr Lys Pro Glu Ile Leu Thr Tyr Asp Arg Leu Val Asn Gly Met Leu
                245                 250                 255     
Gln Cys Val Ala Ala Gly Phe Pro Glu Pro Thr Ile Asp Trp Tyr Phe
            260                 265                 270         
Cys Pro Gly Thr Glu Gln Arg Cys Ser Ala Ser Val Leu Pro Val Asp
        275                 280                 285             
Val Gln Thr Leu Asn Ser Ser Gly Pro Pro Phe Gly Lys Leu Val Val
    290                 295                 300                 
Gln Ser Ser Ile Asp Ser Ser Ala Phe Lys His Asn Gly Thr Val Glu
305                 310                 315                 320 
Cys Lys Ala Tyr Asn Asp Val Gly Lys Thr Ser Ala Tyr Phe Asn Phe
                325                 330                 335     
Ala Phe Lys Gly Asn Asn Lys Glu Gln Ile His Pro His Thr Leu Phe
            340                 345                 350         
Thr Pro Leu Leu Ile Gly Phe Val Ile Val Ala Gly Met Met Cys Ile
        355                 360                 365             
Ile Val Met Ile Leu Thr Tyr Lys Tyr Leu Gln Lys Pro Met Tyr Glu
    370                 375                 380                 
Val Gln Trp Lys Val Val Glu Glu Ile Asn Gly Asn Asn Tyr Val Tyr
385                 390                 395                 400 
Ile Asp Pro Thr Gln Leu Pro Tyr Asp His Lys Trp Glu Phe Pro Arg
                405                 410                 415     
Asn Arg Leu Ser Phe Gly Lys Thr Leu Gly Ala Gly Ala Phe Gly Lys
            420                 425                 430         
Val Val Glu Ala Thr Ala Tyr Gly Leu Ile Lys Ser Asp Ala Ala Met
        435                 440                 445             
Thr Val Ala Val Lys Met Leu Lys Pro Ser Ala His Leu Thr Glu Arg
    450                 455                 460                 
Glu Ala Leu Met Ser Glu Leu Lys Val Leu Ser Tyr Leu Gly Asn His
465                 470                 475                 480 
Met Asn Ile Val Asn Leu Leu Gly Ala Cys Thr Ile Gly Gly Pro Thr
                485                 490                 495     
Leu Val Ile Thr Glu Tyr Cys Cys Tyr Gly Asp Leu Leu Asn Phe Leu
            500                 505                 510         
Arg Arg Lys Arg Asp Ser Phe Ile Cys Ser Lys Gln Glu Asp His Ala
        515                 520                 525             
Glu Ala Ala Leu Tyr Lys Asn Leu Leu His Ser Lys Glu Ser Ser Cys
    530                 535                 540                 
Ser Asp Ser Thr Asn Glu Tyr Met Asp Met Lys Pro Gly Val Ser Tyr
545                 550                 555                 560 
Val Val Pro Thr Lys Ala Asp Lys Arg Arg Ser Val Arg Ile Gly Ser
                565                 570                 575     
Tyr Ile Glu Arg Asp Val Thr Pro Ala Ile Met Glu Asp Asp Glu Leu
            580                 585                 590         
Ala Leu Asp Leu Glu Asp Leu Leu Ser Phe Ser Tyr Gln Val Ala Lys
        595                 600                 605             
Gly Met Ala Phe Leu Ala Ser Lys Asn Cys Ile His Arg Asp Leu Ala
    610                 615                 620                 
Ala Arg Asn Ile Leu Leu Thr His Gly Arg Ile Thr Lys Ile Cys Asp
625                 630                 635                 640 
Phe Gly Leu Ala Arg Asp Ile Lys Asn Asp Ser Asn Tyr Val Val Lys
                645                 650                 655     
Gly Asn Ala Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ser Ile Phe
            660                 665                 670         
Asn Cys Val Tyr Thr Phe Glu Ser Asp Val Trp Ser Tyr Gly Ile Phe
        675                 680                 685             
Leu Trp Glu Leu Phe Ser Leu Gly Ser Ser Pro Tyr Pro Gly Met Pro
    690                 695                 700                 
Val Asp Ser Lys Phe Tyr Lys Met Ile Lys Glu Gly Phe Arg Met Leu
705                 710                 715                 720 
Ser Pro Glu His Ala Pro Ala Glu Met Tyr Asp Ile Met Lys Thr Cys
                725                 730                 735     
Trp Asp Ala Asp Pro Leu Lys Arg Pro Thr Phe Lys Gln Ile Val Gln
            740                 745                 750         
Leu Ile Glu Lys Gln Ile Ser Glu Ser Thr Asn His Ile Tyr Ser Asn
        755                 760                 765             
Leu Ala Asn Cys Ser Pro Asn Arg Gln Lys Pro Val Val Asp His Ser
    770                 775                 780                 
Val Arg Ile Asn Ser Val Gly Ser Thr Ala Ser Ser Ser Gln Pro Leu
785                 790                 795                 800 
Leu Val His Asp Asp Val
                805     


<210> 2336
<211> 890
<212> PRT
<213> Homo sapiens

<400> 2336
Met Asn Tyr Val Gly Gln Leu Ala Gly Gln Val Phe Val Thr Val Lys
 1               5                  10                  15      
Glu Leu Tyr Lys Gly Leu Asn Pro Ala Thr Leu Ser Gly Cys Ile Asp
            20                  25                  30          
Ile Ile Val Ile Arg Gln Pro Asn Gly Asn Leu Gln Cys Ser Pro Phe
        35                  40                  45              
His Val Arg Phe Gly Lys Met Gly Val Leu Arg Ser Arg Glu Lys Val
    50                  55                  60                  
Val Asp Ile Glu Ile Asn Gly Glu Ser Val Asp Leu His Met Lys Leu
65                  70                  75                  80  
Gly Asp Asn Gly Glu Ala Phe Phe Val Gln Glu Thr Asp Asn Asp Gln
                85                  90                  95      
Glu Val Ile Pro Met His Leu Ala Thr Ser Pro Ile Leu Ser Glu Gly
            100                 105                 110         
Ala Ser Arg Met Glu Cys Gln Leu Lys Arg Gly Ser Val Asp Arg Met
        115                 120                 125             
Arg Gly Leu Asp Pro Ser Thr Pro Ala Gln Val Ile Ala Pro Ser Glu
    130                 135                 140                 
Thr Pro Ser Ser Ser Ser Val Val Lys Lys Arg Arg Lys Arg Arg Arg
145                 150                 155                 160 
Lys Ser Gln Leu Asp Ser Leu Lys Arg Asp Asp Asn Met Asn Thr Ser
                165                 170                 175     
Glu Asp Glu Asp Met Phe Pro Ile Glu Met Ser Ser Asp Glu Ala Met
            180                 185                 190         
Glu Leu Leu Glu Ser Ser Arg Thr Leu Pro Asn Asp Ile Pro Pro Phe
        195                 200                 205             
Gln Asp Asp Ile Pro Glu Glu Asn Leu Ser Leu Ala Val Ile Tyr Pro
    210                 215                 220                 
Gln Ser Ala Ser Tyr Pro Asn Ser Asp Arg Glu Trp Ser Pro Thr Pro
225                 230                 235                 240 
Ser Pro Ser Gly Ser Arg Pro Ser Thr Pro Lys Ser Asp Ser Glu Leu
                245                 250                 255     
Val Ser Lys Ser Thr Glu Arg Thr Gly Gln Lys Asn Pro Glu Met Leu
            260                 265                 270         
Trp Leu Trp Gly Glu Leu Pro Gln Ala Ala Lys Ser Ser Ser Pro His
        275                 280                 285             
Lys Met Lys Glu Ser Ser Pro Leu Ser Ser Arg Lys Ile Cys Asp Lys
    290                 295                 300                 
Ser His Phe Gln Ala Ile His Ser Glu Ser Ser Asp Thr Phe Ser Asp
305                 310                 315                 320 
Gln Ser Pro Thr Leu Val Gly Gly Ala Leu Leu Asp Gln Asn Lys Pro
                325                 330                 335     
Gln Thr Glu Met Gln Phe Val Asn Glu Glu Asp Leu Glu Thr Leu Gly
            340                 345                 350         
Ala Ala Ala Pro Leu Leu Pro Met Ile Glu Glu Leu Lys Pro Pro Ser
        355                 360                 365             
Ala Ser Val Val Gln Thr Ala Asn Lys Thr Asp Ser Pro Ser Arg Lys
    370                 375                 380                 
Arg Asp Lys Arg Ser Arg His Leu Gly Ala Asp Gly Val Tyr Leu Asp
385                 390                 395                 400 
Asp Leu Thr Asp Met Asp Pro Glu Val Ala Ala Leu Tyr Phe Pro Lys
                405                 410                 415     
Asn Gly Asp Pro Ser Gly Leu Ala Lys His Ala Ser Asp Asn Gly Ala
            420                 425                 430         
Arg Ser Ala Asn Gln Ser Pro Gln Ser Val Gly Ser Ser Gly Val Asp
        435                 440                 445             
Ser Gly Val Glu Ser Thr Ser Asp Gly Leu Arg Asp Leu Pro Ser Ile
    450                 455                 460                 
Ala Ile Ser Leu Cys Gly Gly Leu Ser Asp His Arg Glu Ile Thr Lys
465                 470                 475                 480 
Asp Ala Phe Leu Glu Gln Ala Val Ser Tyr Gln Gln Phe Val Asp Asn
                485                 490                 495     
Pro Ala Ile Ile Asp Asp Pro Asn Leu Val Val Lys Ile Gly Ser Lys
            500                 505                 510         
Tyr Tyr Asn Trp Thr Thr Ala Ala Pro Leu Leu Leu Ala Met Gln Ala
        515                 520                 525             
Phe Gln Lys Pro Leu Pro Lys Ala Thr Val Glu Ser Ile Met Arg Asp
    530                 535                 540                 
Lys Met Pro Lys Lys Gly Gly Arg Trp Trp Phe Ser Trp Arg Gly Arg
545                 550                 555                 560 
Asn Thr Thr Ile Lys Glu Glu Ser Lys Pro Glu Gln Cys Leu Ala Gly
                565                 570                 575     
Lys Ala His Ser Thr Gly Glu Gln Pro Pro Gln Leu Ser Leu Ala Thr
            580                 585                 590         
Arg Val Lys His Glu Ser Ser Ser Ser Asp Glu Glu Arg Ala Ala Ala
        595                 600                 605             
Lys Pro Ser Asn Ala Gly His Leu Pro Leu Leu Pro Asn Val Ser Tyr
    610                 615                 620                 
Lys Lys Thr Leu Arg Leu Thr Ser Glu Gln Leu Lys Ser Leu Lys Leu
625                 630                 635                 640 
Lys Asn Gly Pro Asn Asp Val Val Phe Ser Val Thr Thr Gln Tyr Gln
                645                 650                 655     
Gly Thr Cys Arg Cys Glu Gly Thr Ile Tyr Leu Trp Asn Trp Asp Asp
            660                 665                 670         
Lys Val Ile Ile Ser Asp Ile Asp Gly Thr Ile Thr Arg Ser Asp Thr
        675                 680                 685             
Leu Gly His Ile Leu Pro Thr Leu Gly Lys Asp Trp Thr His Gln Gly
    690                 695                 700                 
Ile Ala Lys Leu Tyr His Lys Val Ser Gln Asn Gly Tyr Lys Phe Leu
705                 710                 715                 720 
Tyr Cys Ser Ala Arg Ala Ile Gly Met Ala Asp Met Thr Arg Gly Tyr
                725                 730                 735     
Leu His Trp Val Asn Glu Arg Gly Thr Val Leu Pro Gln Gly Pro Leu
            740                 745                 750         
Leu Leu Ser Pro Ser Ser Leu Phe Ser Ala Leu His Arg Glu Val Ile
        755                 760                 765             
Glu Lys Lys Pro Glu Lys Phe Lys Val Gln Cys Leu Thr Asp Ile Lys
    770                 775                 780                 
Asn Leu Phe Phe Pro Asn Thr Glu Pro Phe Tyr Ala Ala Phe Gly Asn
785                 790                 795                 800 
Arg Pro Ala Asp Val Tyr Ser Tyr Lys Gln Val Gly Val Ser Leu Asn
                805                 810                 815     
Arg Ile Phe Thr Val Asn Pro Lys Gly Glu Leu Val Gln Glu His Ala
            820                 825                 830         
Lys Thr Asn Ile Ser Ser Tyr Val Arg Leu Cys Glu Val Val Asp His
        835                 840                 845             
Val Phe Pro Leu Leu Lys Arg Ser His Ser Ser Asp Phe Pro Cys Ser
    850                 855                 860                 
Asp Thr Phe Ser Asn Phe Thr Phe Trp Arg Glu Pro Leu Pro Pro Phe
865                 870                 875                 880 
Glu Asn Gln Asp Ile His Ser Ala Ser Ala
                885                 890 


<210> 2337
<211> 114
<212> PRT
<213> Homo sapiens

<400> 2337
Met Phe Ser Ser Thr Trp Lys Asp Arg Gln Gln Pro Thr Leu Ile Trp
 1               5                  10                  15      
Lys Thr Gly Pro Arg Leu Asp Thr Arg Gly Thr Lys Pro Gly Met Gly
            20                  25                  30          
Trp Pro Leu Cys Pro Arg Arg Arg Asp Gly Gln Asn Gly Pro Arg Val
        35                  40                  45              
Leu Phe Pro Glu Lys Gly Glu Lys Asp Gly Ile Ala Thr His Pro Pro
    50                  55                  60                  
Thr Leu Val Arg Glu Glu Asn Leu Cys Phe Trp Ser Phe Ser Arg Asp
65                  70                  75                  80  
Cys Val Leu Gln Val Gln Lys Thr Ala Cys Tyr Leu Gln Ala Arg Phe
                85                  90                  95      
Ser Arg Ala His Gly Ser Pro Val Ala Phe Ser Val Asn Leu Ala Gly
            100                 105                 110         
Met Asp
        


<210> 2338
<211> 112
<212> PRT
<213> Homo sapiens

<400> 2338
Met Ala Ala Ala Leu Ala Arg Leu Gly Leu Arg Pro Val Lys Gln Val
 1               5                  10                  15      
Arg Val Gln Phe Cys Pro Phe Glu Lys Asn Val Glu Ser Thr Arg Thr
            20                  25                  30          
Phe Leu Gln Thr Val Ser Ser Glu Lys Val Arg Ser Thr Asn Leu Asn
        35                  40                  45              
Cys Ser Val Ile Ala Asp Val Arg His Asp Gly Ser Glu Pro Cys Val
    50                  55                  60                  
Asp Val Leu Phe Gly Asp Gly His Arg Leu Ile Met Arg Gly Ala His
65                  70                  75                  80  
Leu Thr Ala Leu Glu Met Leu Thr Ala Phe Ala Ser His Ile Arg Ala
                85                  90                  95      
Arg Asp Ala Ala Gly Ser Gly Asp Lys Pro Gly Ala Asp Thr Gly Arg
            100                 105                 110         


<210> 2339
<211> 270
<212> PRT
<213> Homo sapiens

<400> 2339
Met Ala Glu Leu Ala Ser Trp Ala Leu Leu Val Val Val Val Gln Val
 1               5                  10                  15      
Ala Leu Leu Glu Ser Glu Asp Leu Met Glu Met Leu Val Ala Leu Gly
            20                  25                  30          
Ser Leu Val Ser Trp Asp Pro Glu Val Phe Leu Val Pro Leu Glu Ile
        35                  40                  45              
Ser Ala Pro Leu Glu Lys Lys Val Leu Ser Ala Ser Leu Ala Ser Thr
    50                  55                  60                  
Ala Gly Leu Ala Gln Leu Ala Gln Leu Glu Gln Glu Glu Ser Leu Ala
65                  70                  75                  80  
Thr Leu Asp Ser Leu Asp Pro Lys Ala Pro Leu Val Ile Leu Ala Lys
                85                  90                  95      
Thr Val Ile Lys Val Met Leu Val Leu Leu Val Leu Gly Val Leu Gln
            100                 105                 110         
Val Leu Met Glu Thr Met Val Leu Arg Asp Leu Leu Asp His Arg Val
        115                 120                 125             
Phe Lys Val Glu Lys Val Asn Arg Val Pro Leu Val Leu Gln Ala Ser
    130                 135                 140                 
Arg Val Cys Leu Ala Pro Gln Val Pro Leu Val Lys Leu Ala Asn Gln
145                 150                 155                 160 
Glu Lys Gly Val Ser Met Val Ser Leu Val Ser Leu Val Leu Leu Val
                165                 170                 175     
Gln Glu Gly Asn Ala Val Pro Gln Val Arg Val Val Leu Pro Val Leu
            180                 185                 190         
Leu Val Leu Leu Glu Ala Glu Val Leu Leu Asp Pro Gln Gly Leu Met
        195                 200                 205             
Glu Thr Arg Val Asn Leu Val Trp Leu Val Leu Trp Ala Leu Leu Val
    210                 215                 220                 
His Leu Val Leu Val Asp Ser Gln Glu Arg Gly Val Leu Leu Ala Tyr
225                 230                 235                 240 
Leu Glu Ala Arg Glu Lys Arg Val Asn Leu Val Ser Glu Val Lys Leu
                245                 250                 255     
Val Thr Leu Ala Glu Met Val Leu Val Val Leu Leu Val Leu
            260                 265                 270 


<210> 2340
<211> 458
<212> PRT
<213> Homo sapiens

<400> 2340
Met Ala Ser Thr Ile Thr Gly Ser Gln Asp Cys Ile Val Asn His Arg
 1               5                  10                  15      
Gly Glu Val Asp Gly Glu Pro Glu Leu Asp Ile Ser Pro Cys Gln Gln
            20                  25                  30          
Trp Gly Glu Ala Ser Ser Pro Ile Ser Arg Asn Arg Asp Ser Val Met
        35                  40                  45              
Thr Leu Gln Ser Gly Cys Phe Glu Asn Ile Glu Ser Glu Thr Tyr Leu
    50                  55                  60                  
Pro Leu Lys Val Ser Ser Gln Ile Asp Thr Gln Asp Ser Ser Val Lys
65                  70                  75                  80  
Phe Cys Lys Asn Glu Pro Gln Asp His Gln Glu Ser Arg Arg Leu Phe
                85                  90                  95      
Val Met Glu Glu Ser Thr Glu Arg Lys Val Ile Lys Gly Glu Ser Cys
            100                 105                 110         
Ser Glu Asn Leu Gln Val Lys Leu Val Ser Asp Gly Gln Glu Leu Ala
        115                 120                 125             
Ser Pro Leu Leu Asn Gly Glu Ala Thr Cys Gln Asn Gly Gln Leu Lys
    130                 135                 140                 
Glu Ser Leu Asp Pro Ile Asp Cys Asn Cys Lys Asp Ile His Gly Trp
145                 150                 155                 160 
Lys Ser Gln Val Val Ser Cys Ser Gln Gln Arg Ala His Thr Glu Glu
                165                 170                 175     
Lys Pro Cys Asp His Asn Asn Cys Gly Lys Ile Leu Asn Thr Ser Pro
            180                 185                 190         
Asp Gly His Pro Tyr Glu Lys Ile His Thr Ala Glu Lys Gln Tyr Glu
        195                 200                 205             
Cys Ser Gln Cys Gly Lys Asn Phe Ser Gln Ser Ser Glu Leu Leu Leu
    210                 215                 220                 
His Gln Arg Asp His Thr Glu Glu Lys Pro Tyr Lys Cys Glu Gln Cys
225                 230                 235                 240 
Gly Lys Gly Phe Thr Arg Ser Ser Ser Leu Leu Ile His Gln Ala Val
                245                 250                 255     
His Thr Asp Glu Lys Pro Tyr Lys Cys Asp Lys Cys Gly Lys Gly Phe
            260                 265                 270         
Thr Arg Ser Ser Ser Leu Leu Ile His His Ala Val His Thr Gly Glu
        275                 280                 285             
Lys Pro Tyr Lys Cys Asp Lys Cys Gly Lys Gly Phe Ser Gln Ser Ser
    290                 295                 300                 
Lys Leu His Ile His Gln Arg Val His Thr Gly Glu Lys Pro Tyr Glu
305                 310                 315                 320 
Cys Glu Glu Cys Gly Met Ser Phe Ser Gln Arg Ser Asn Leu His Ile
                325                 330                 335     
His Gln Arg Val His Thr Gly Glu Arg Pro Tyr Lys Cys Gly Glu Cys
            340                 345                 350         
Gly Lys Gly Phe Ser Gln Ser Ser Asn Leu His Ile His Arg Cys Ile
        355                 360                 365             
His Thr Gly Glu Lys Pro Tyr Gln Cys Tyr Glu Cys Gly Lys Gly Phe
    370                 375                 380                 
Ser Gln Ser Ser Asp Leu Arg Ile His Leu Arg Val His Thr Gly Glu
385                 390                 395                 400 
Lys Pro Tyr His Cys Gly Lys Cys Gly Lys Gly Phe Ser Gln Ser Ser
                405                 410                 415     
Lys Leu Leu Ile His Gln Arg Val His Thr Gly Glu Lys Pro Tyr Glu
            420                 425                 430         
Cys Ser Lys Cys Gly Lys Gly Phe Ser Gln Ser Ser Asn Leu His Ile
        435                 440                 445             
His Gln Arg Val His Lys Lys Asp Pro Arg
    450                 455             


<210> 2341
<211> 609
<212> PRT
<213> Homo sapiens

<400> 2341
Met Pro Ser Asp Pro Pro Phe Asn Thr Arg Arg Ala Tyr Thr Ser Glu
 1               5                  10                  15      
Asp Glu Ala Trp Lys Ser Tyr Leu Glu Asn Pro Leu Thr Ala Ala Thr
            20                  25                  30          
Lys Ala Met Met Ser Ile Asn Gly Asp Glu Asp Ser Ala Ala Ala Leu
        35                  40                  45              
Gly Leu Leu Tyr Asp Tyr Tyr Lys Val Pro Arg Asp Lys Arg Leu Leu
    50                  55                  60                  
Ser Val Ser Lys Ala Ser Asp Ser Gln Glu Asp Gln Glu Lys Arg Asn
65                  70                  75                  80  
Cys Leu Gly Thr Ser Glu Ala Gln Ser Asn Leu Ser Gly Gly Glu Asn
                85                  90                  95      
Arg Val Gln Val Leu Lys Thr Val Pro Val Asn Leu Ser Leu Asn Gln
            100                 105                 110         
Asp His Leu Glu Asn Ser Lys Arg Glu Gln Tyr Ser Ile Ser Phe Pro
        115                 120                 125             
Glu Ser Ser Ala Ile Ile Pro Val Ser Gly Ile Thr Val Val Lys Ala
    130                 135                 140                 
Glu Asp Phe Thr Pro Val Phe Met Ala Pro Pro Val His Tyr Pro Arg
145                 150                 155                 160 
Gly Asp Gly Glu Glu Gln Arg Val Val Ile Phe Glu Gln Thr Gln Tyr
                165                 170                 175     
Asp Val Pro Ser Leu Ala Thr His Ser Ala Tyr Leu Lys Asp Asp Gln
            180                 185                 190         
Arg Ser Thr Pro Asp Ser Thr Tyr Ser Glu Ser Phe Lys Asp Ala Ala
        195                 200                 205             
Thr Glu Lys Phe Arg Ser Ala Ser Val Gly Ala Glu Glu Tyr Met Tyr
    210                 215                 220                 
Asp Gln Thr Ser Ser Gly Thr Phe Gln Tyr Thr Leu Glu Ala Thr Lys
225                 230                 235                 240 
Ser Leu Arg Gln Lys Gln Gly Glu Gly Pro Met Thr Tyr Leu Asn Lys
                245                 250                 255     
Gly Gln Phe Tyr Ala Ile Thr Leu Ser Glu Thr Gly Asp Asn Lys Cys
            260                 265                 270         
Phe Arg His Pro Ile Ser Lys Val Arg Ser Val Val Met Val Val Phe
        275                 280                 285             
Ser Glu Asp Lys Asn Arg Asp Glu Gln Leu Lys Tyr Trp Lys Tyr Trp
    290                 295                 300                 
His Ser Arg Gln His Thr Ala Lys Gln Arg Val Leu Asp Ile Ala Asp
305                 310                 315                 320 
Tyr Lys Glu Ser Phe Asn Thr Ile Gly Asn Ile Glu Glu Ile Ala Tyr
                325                 330                 335     
Asn Ala Val Ser Phe Thr Trp Asp Val Asn Glu Glu Ala Lys Ile Phe
            340                 345                 350         
Ile Thr Val Asn Cys Leu Ser Thr Asp Phe Ser Ser Gln Lys Gly Val
        355                 360                 365             
Lys Gly Leu Pro Leu Met Ile Gln Ile Asp Thr Tyr Ser Tyr Asn Asn
    370                 375                 380                 
Arg Ser Asn Lys Pro Ile His Arg Ala Tyr Cys Gln Ile Lys Val Phe
385                 390                 395                 400 
Cys Asp Lys Gly Ala Glu Arg Lys Ile Arg Asp Glu Glu Arg Lys Gln
                405                 410                 415     
Asn Arg Lys Lys Gly Lys Gly Gln Ala Ser Gln Thr Gln Cys Asn Ser
            420                 425                 430         
Ser Ser Asp Gly Lys Leu Ala Ala Ile Pro Leu Gln Lys Lys Ser Asp
        435                 440                 445             
Ile Thr Tyr Phe Lys Thr Met Pro Asp Leu His Ser Gln Pro Val Leu
    450                 455                 460                 
Phe Ile Pro Asp Val His Phe Ala Asn Leu Gln Arg Thr Gly Gln Val
465                 470                 475                 480 
Tyr Tyr Asn Thr Asp Asp Glu Arg Glu Gly Gly Ser Val Leu Val Lys
                485                 490                 495     
Arg Met Phe Arg Pro Met Glu Glu Glu Phe Gly Pro Val Pro Ser Lys
            500                 505                 510         
Gln Met Lys Glu Glu Gly Thr Lys Arg Val Leu Leu Tyr Val Arg Lys
        515                 520                 525             
Glu Thr Asp Asp Val Phe Asp Ala Leu Met Leu Lys Ser Pro Thr Val
    530                 535                 540                 
Lys Gly Leu Met Glu Ala Ile Ser Glu Lys Tyr Gly Leu Pro Val Glu
545                 550                 555                 560 
Lys Ile Ala Lys Leu Tyr Lys Lys Ser Lys Lys Gly Ile Leu Val Asn
                565                 570                 575     
Met Asp Asp Asn Ile Ile Glu His Tyr Ser Asn Glu Asp Thr Phe Ile
            580                 585                 590         
Leu Asn Met Glu Ser Met Val Glu Gly Phe Lys Val Thr Leu Met Glu
        595                 600                 605             
Ile
    


<210> 2342
<211> 906
<212> PRT
<213> Homo sapiens

<400> 2342
Met Val Gly Leu Leu Leu Phe Phe Phe Pro Ala Ile Phe Leu Glu Val
 1               5                  10                  15      
Ser Leu Leu Pro Arg Ser Pro Gly Arg Lys Val Leu Leu Ala Gly Ala
            20                  25                  30          
Ser Ser Gln Arg Ser Val Ala Arg Met Asp Gly Asp Val Ile Ile Gly
        35                  40                  45              
Ala Leu Phe Ser Val His His Gln Pro Pro Ala Glu Lys Val Pro Glu
    50                  55                  60                  
Arg Lys Cys Gly Glu Ile Arg Glu Gln Tyr Gly Ile Gln Arg Val Glu
65                  70                  75                  80  
Ala Met Phe His Thr Leu Asp Lys Ile Asn Ala Asp Pro Val Leu Leu
                85                  90                  95      
Pro Asn Ile Thr Leu Gly Ser Glu Ile Arg Asp Ser Cys Trp His Ser
            100                 105                 110         
Ser Val Ala Leu Glu Gln Ser Ile Glu Phe Ile Arg Asp Ser Leu Ile
        115                 120                 125             
Ser Ile Arg Asp Glu Lys Asp Gly Ile Asn Arg Cys Leu Pro Asp Gly
    130                 135                 140                 
Gln Ser Leu Pro Pro Gly Arg Thr Lys Lys Pro Ile Ala Gly Val Ile
145                 150                 155                 160 
Gly Pro Gly Ser Ser Ser Val Ala Ile Gln Val Gln Asn Leu Leu Gln
                165                 170                 175     
Leu Phe Asp Ile Pro Gln Ile Ala Tyr Ser Ala Thr Ser Ile Asp Leu
            180                 185                 190         
Ser Asp Lys Thr Leu Tyr Lys Tyr Phe Leu Arg Val Val Pro Ser Asp
        195                 200                 205             
Thr Leu Gln Ala Arg Ala Met Leu Asp Ile Val Lys Arg Tyr Asn Trp
    210                 215                 220                 
Thr Tyr Val Ser Ala Val His Thr Glu Gly Asn Tyr Gly Glu Ser Gly
225                 230                 235                 240 
Met Asp Ala Phe Lys Glu Leu Ala Ala Gln Glu Gly Leu Cys Ile Ala
                245                 250                 255     
His Ser Asp Lys Ile Tyr Ser Asn Ala Gly Glu Lys Ser Phe Asp Arg
            260                 265                 270         
Leu Leu Arg Lys Leu Arg Glu Arg Leu Pro Lys Ala Arg Val Val Val
        275                 280                 285             
Cys Phe Cys Glu Gly Met Thr Val Arg Gly Leu Leu Ser Ala Met Arg
    290                 295                 300                 
Arg Leu Gly Val Val Gly Glu Phe Ser Leu Ile Gly Ser Asp Gly Trp
305                 310                 315                 320 
Ala Asp Arg Asp Glu Val Ile Glu Gly Tyr Glu Val Glu Ala Asn Gly
                325                 330                 335     
Gly Ile Thr Ile Lys Leu Gln Ser Pro Glu Val Arg Ser Phe Asp Asp
            340                 345                 350         
Tyr Phe Leu Lys Leu Arg Leu Asp Thr Asn Thr Arg Asn Pro Trp Phe
        355                 360                 365             
Pro Glu Phe Trp Gln His Arg Phe Gln Cys Arg Leu Pro Gly His Leu
    370                 375                 380                 
Leu Glu Asn Pro Asn Phe Lys Arg Ile Cys Thr Gly Asn Glu Ser Leu
385                 390                 395                 400 
Glu Glu Asn Tyr Val Gln Asp Ser Lys Met Gly Phe Val Ile Asn Ala
                405                 410                 415     
Ile Tyr Ala Met Ala His Gly Leu Gln Asn Met His His Ala Leu Cys
            420                 425                 430         
Pro Gly His Val Gly Leu Cys Asp Ala Met Lys Pro Ile Asp Gly Ser
        435                 440                 445             
Lys Leu Leu Asp Phe Leu Ile Lys Ser Ser Phe Ile Gly Val Ser Gly
    450                 455                 460                 
Glu Glu Val Trp Phe Asp Glu Lys Gly Asp Ala Pro Gly Arg Tyr Asp
465                 470                 475                 480 
Ile Met Asn Leu Gln Tyr Thr Glu Ala Asn Arg Tyr Asp Tyr Val His
                485                 490                 495     
Val Gly Thr Trp His Glu Gly Val Leu Asn Ile Asp Asp Tyr Lys Ile
            500                 505                 510         
Gln Met Asn Lys Ser Gly Val Val Arg Ser Val Cys Ser Glu Pro Cys
        515                 520                 525             
Leu Lys Gly Gln Ile Lys Val Ile Arg Lys Gly Glu Val Ser Cys Cys
    530                 535                 540                 
Trp Ile Cys Thr Ala Cys Lys Glu Asn Glu Tyr Val Gln Asp Glu Phe
545                 550                 555                 560 
Thr Cys Lys Ala Cys Asp Leu Gly Trp Trp Pro Asn Ala Asp Leu Thr
                565                 570                 575     
Gly Cys Glu Pro Ile Pro Val Arg Tyr Leu Glu Trp Ser Asn Ile Glu
            580                 585                 590         
Ser Ile Ile Ala Ile Ala Phe Ser Cys Leu Gly Ile Leu Val Thr Leu
        595                 600                 605             
Phe Val Thr Leu Ile Phe Val Leu Tyr Arg Asp Thr Pro Val Val Lys
    610                 615                 620                 
Ser Ser Ser Arg Glu Leu Cys Tyr Ile Ile Leu Ala Gly Ile Phe Leu
625                 630                 635                 640 
Gly Tyr Val Cys Pro Phe Thr Leu Ile Ala Lys Pro Thr Thr Thr Ser
                645                 650                 655     
Cys Tyr Leu Gln Arg Leu Leu Val Gly Leu Ser Ser Ala Met Cys Tyr
            660                 665                 670         
Ser Ala Leu Val Thr Lys Thr Asn Arg Ile Ala Arg Ile Leu Ala Gly
        675                 680                 685             
Ser Lys Lys Lys Ile Cys Thr Arg Lys Pro Arg Phe Met Ser Ala Trp
    690                 695                 700                 
Ala Gln Val Ile Ile Ala Ser Ile Leu Ile Ser Val Gln Leu Thr Leu
705                 710                 715                 720 
Val Val Thr Leu Ile Ile Met Glu Pro Pro Met Pro Ile Leu Ser Tyr
                725                 730                 735     
Pro Ser Ile Lys Glu Val Tyr Leu Ile Cys Asn Thr Ser Asn Leu Gly
            740                 745                 750         
Val Val Ala Pro Leu Gly Tyr Asn Gly Leu Leu Ile Met Ser Cys Thr
        755                 760                 765             
Tyr Tyr Ala Phe Lys Thr Arg Asn Val Pro Ala Asn Phe Asn Glu Ala
    770                 775                 780                 
Lys Tyr Ile Ala Phe Thr Met Tyr Thr Thr Cys Ile Ile Trp Leu Ala
785                 790                 795                 800 
Phe Val Pro Ile Tyr Phe Gly Ser Asn Tyr Lys Ile Ile Thr Thr Cys
                805                 810                 815     
Phe Ala Val Ser Leu Ser Val Thr Val Ala Leu Gly Cys Met Phe Thr
            820                 825                 830         
Pro Lys Met Tyr Ile Ile Ile Ala Lys Pro Glu Arg Asn Val Arg Ser
        835                 840                 845             
Ala Phe Thr Thr Ser Asp Val Val Arg Met His Val Gly Asp Gly Lys
    850                 855                 860                 
Leu Pro Cys Arg Ser Asn Thr Phe Leu Asn Ile Phe Arg Arg Lys Lys
865                 870                 875                 880 
Ala Gly Ala Gly Asn Ala Lys Lys Arg Gln Pro Glu Phe Ser Pro Thr
                885                 890                 895     
Ser Gln Cys Pro Ser Ala His Val Gln Leu
            900                 905     


<210> 2343
<211> 292
<212> PRT
<213> Homo sapiens

<400> 2343
Met Ser Ala Ser Val Lys Glu Ser Leu Gln Leu Gln Leu Leu Glu Met
 1               5                  10                  15      
Glu Met Leu Phe Ser Met Phe Pro Asn Gln Gly Glu Val Lys Leu Glu
            20                  25                  30          
Asp Val Asn Ala Leu Thr Asn Ile Lys Arg Tyr Leu Glu Gly Thr Arg
        35                  40                  45              
Glu Ala Leu Pro Pro Lys Ile Glu Phe Val Ile Thr Leu Gln Ile Glu
    50                  55                  60                  
Glu Pro Lys Val Lys Ile Asp Leu Gln Val Thr Met Pro His Ser Tyr
65                  70                  75                  80  
Pro Tyr Val Ala Leu Gln Leu Phe Gly Arg Ser Ser Glu Leu Asp Arg
                85                  90                  95      
His Gln Gln Leu Leu Leu Asn Lys Gly Leu Thr Ser Tyr Ile Gly Thr
            100                 105                 110         
Phe Asp Pro Gly Glu Leu Cys Val Cys Ala Ala Ile Gln Trp Leu Gln
        115                 120                 125             
Asp Asn Ser Ala Ser Tyr Phe Leu Asn Arg Lys Leu Val Tyr Glu Pro
    130                 135                 140                 
Ser Thr Gln Ala Lys Pro Val Lys Asn Thr Phe Leu Arg Met Trp Ile
145                 150                 155                 160 
Tyr Ser His His Ile Tyr Gln Gln Asp Leu Arg Lys Lys Ile Leu Asp
                165                 170                 175     
Val Gly Lys Arg Leu Asp Val Thr Gly Phe Cys Met Thr Gly Lys Pro
            180                 185                 190         
Gly Ile Ile Cys Val Glu Gly Phe Lys Glu His Cys Glu Glu Phe Trp
        195                 200                 205             
His Thr Ile Arg Tyr Pro Asn Trp Lys His Ile Ser Cys Lys His Ala
    210                 215                 220                 
Glu Ser Val Glu Thr Glu Gly Asn Gly Glu Asp Leu Arg Leu Phe His
225                 230                 235                 240 
Ser Phe Glu Glu Leu Leu Leu Glu Ala His Gly Asp Tyr Gly Leu Arg
                245                 250                 255     
Asn Asp Tyr His Met Asn Leu Gly Gln Phe Leu Glu Phe Leu Lys Lys
            260                 265                 270         
His Lys Ser Glu His Val Phe Gln Ile Leu Phe Gly Ile Glu Ser Lys
        275                 280                 285             
Ser Ser Asp Ser
    290         


<210> 2344
<211> 1019
<212> PRT
<213> Homo sapiens

<400> 2344
Met Asp Leu Asn Asn Asn Ser Leu Lys Thr Lys Ala Gln Val Pro Met
 1               5                  10                  15      
Val Leu Thr Ala Gly Pro Lys Trp Leu Leu Asp Val Thr Trp Gln Gly
            20                  25                  30          
Val Glu Asp Asn Lys Asn Asn Cys Ile Val Tyr Ser Lys Gly Gly Gln
        35                  40                  45              
Leu Trp Cys Thr Thr Thr Lys Ala Ile Ser Glu Gly Glu Glu Leu Ile
    50                  55                  60                  
Ala Phe Val Val Asp Phe Asp Ser Arg Leu Gln Ala Ala Ser Gln Met
65                  70                  75                  80  
Thr Leu Thr Glu Gly Met Tyr Pro Ala Arg Leu Leu Asp Ser Ile Gln
                85                  90                  95      
Leu Leu Pro Gln Gln Ala Ala Met Ala Ser Ile Leu Pro Thr Ala Ile
            100                 105                 110         
Val Asn Lys Asp Ile Phe Pro Cys Lys Ser Cys Gly Ile Trp Tyr Arg
        115                 120                 125             
Ser Glu Arg Asn Leu Gln Ala His Leu Met Tyr Tyr Cys Ser Gly Arg
    130                 135                 140                 
Gln Arg Glu Ala Ala Pro Val Ser Glu Glu Asn Glu Asp Ser Ala His
145                 150                 155                 160 
Gln Ile Ser Ser Leu Cys Pro Phe Pro Gln Cys Thr Lys Ser Phe Ser
                165                 170                 175     
Asn Ala Arg Ala Leu Glu Met His Leu Asn Ser His Ser Gly Val Lys
            180                 185                 190         
Met Glu Glu Phe Leu Pro Pro Gly Ala Ser Leu Lys Cys Thr Val Cys
        195                 200                 205             
Ser Tyr Thr Ala Asp Ser Val Ile Asn Phe His Gln His Leu Phe Ser
    210                 215                 220                 
His Leu Thr Gln Ala Ala Phe Arg Cys Asn His Cys His Phe Gly Phe
225                 230                 235                 240 
Gln Thr Gln Arg Glu Leu Leu Gln His Gln Glu Leu His Val Pro Ser
                245                 250                 255     
Gly Lys Leu Pro Arg Glu Ser Asp Met Glu His Ser Pro Ser Ala Thr
            260                 265                 270         
Glu Asp Ser Leu Gln Pro Ala Thr Asp Leu Leu Thr Arg Ser Glu Leu
        275                 280                 285             
Pro Gln Ser Gln Lys Ala Met Gln Thr Lys Asp Ala Ser Ser Asp Thr
    290                 295                 300                 
Glu Leu Asp Lys Cys Glu Lys Lys Thr Gln Leu Phe Leu Thr Asn Gln
305                 310                 315                 320 
Arg Pro Glu Ile Gln Pro Thr Thr Asn Lys Gln Ser Phe Ser Tyr Thr
                325                 330                 335     
Lys Ile Lys Ser Glu Pro Ser Ser Pro Arg Leu Ala Ser Ser Pro Val
            340                 345                 350         
Gln Pro Asn Ile Gly Pro Ser Phe Pro Val Gly Pro Phe Leu Ser Gln
        355                 360                 365             
Phe Ser Phe Pro Gln Asp Ile Thr Met Val Pro Gln Ala Ser Glu Ile
    370                 375                 380                 
Leu Ala Lys Met Ser Glu Leu Val His Arg Arg Leu Arg His Gly Ser
385                 390                 395                 400 
Ser Ser Tyr Pro Pro Val Ile Tyr Ser Pro Leu Met Pro Lys Gly Ala
                405                 410                 415     
Thr Cys Phe Glu Cys Asn Ile Thr Phe Asn Asn Leu Asp Asn Tyr Leu
            420                 425                 430         
Val His Lys Lys His Tyr Cys Ser Ser Arg Trp Gln Gln Met Ala Lys
        435                 440                 445             
Ser Pro Glu Phe Pro Ser Val Ser Glu Lys Met Pro Glu Ala Leu Ser
    450                 455                 460                 
Pro Asn Thr Gly Gln Thr Ser Ile Asn Leu Leu Asn Pro Ala Ala His
465                 470                 475                 480 
Ser Ala Asp Pro Glu Asn Pro Leu Leu Gln Thr Ser Cys Ile Asn Ser
                485                 490                 495     
Ser Thr Val Leu Asp Leu Ile Gly Pro Asn Gly Lys Gly His Asp Lys
            500                 505                 510         
Asp Phe Ser Thr Gln Thr Lys Lys Leu Ser Thr Ser Ser Asn Asn Asp
        515                 520                 525             
Asp Lys Ile Asn Gly Lys Pro Val Asp Val Lys Asn Pro Ser Val Pro
    530                 535                 540                 
Leu Val Asp Gly Glu Ser Asp Pro Asn Lys Thr Thr Cys Glu Ala Cys
545                 550                 555                 560 
Asn Ile Thr Phe Ser Arg His Glu Thr Tyr Met Val His Lys Gln Tyr
                565                 570                 575     
Tyr Cys Ala Thr Arg His Asp Pro Pro Leu Lys Arg Ser Ala Ser Asn
            580                 585                 590         
Lys Val Pro Ala Met Gln Arg Thr Met Arg Thr Arg Lys Arg Arg Lys
        595                 600                 605             
Met Tyr Glu Met Cys Leu Pro Glu Gln Glu Gln Arg Pro Pro Leu Val
    610                 615                 620                 
Gln Gln Arg Phe Leu Asp Val Ala Asn Leu Asn Asn Pro Cys Thr Ser
625                 630                 635                 640 
Thr Gln Glu Pro Thr Glu Gly Leu Gly Asp Cys Tyr His Pro Arg Cys
                645                 650                 655     
Asp Ile Phe Pro Gly Ile Val Ser Lys His Leu Glu Thr Ser Leu Thr
            660                 665                 670         
Ile Asn Lys Cys Val Pro Val Ser Lys Cys Asp Thr Thr His Ser Ser
        675                 680                 685             
Val Ser Cys Leu Glu Met Asp Val Pro Ile Asp Leu Ser Lys Lys Cys
    690                 695                 700                 
Leu Ser Gln Ser Glu Arg Thr Thr Thr Ser Pro Lys Arg Leu Leu Asp
705                 710                 715                 720 
Tyr His Glu Cys Thr Val Cys Lys Ile Ser Phe Asn Lys Val Glu Asn
                725                 730                 735     
Tyr Leu Ala His Lys Gln Asn Phe Cys Pro Val Thr Ala His Gln Arg
            740                 745                 750         
Asn Asp Leu Gly Gln Leu Asp Gly Lys Val Phe Pro Asn Pro Glu Ser
        755                 760                 765             
Glu Arg Asn Ser Pro Asp Val Ser Tyr Glu Arg Ser Ile Ile Lys Cys
    770                 775                 780                 
Glu Lys Asn Gly Asn Leu Lys Gln Pro Ser Pro Asn Gly Asn Leu Phe
785                 790                 795                 800 
Ser Ser His Leu Ala Thr Leu Gln Gly Leu Lys Val Phe Ser Glu Ala
                805                 810                 815     
Ala Gln Leu Ile Ala Thr Lys Glu Glu Asn Arg His Leu Phe Leu Pro
            820                 825                 830         
Gln Cys Leu Tyr Pro Gly Ala Ile Lys Lys Ala Lys Gly Ala Asp Gln
        835                 840                 845             
Leu Ser Pro Tyr Tyr Gly Ile Lys Pro Ser Asp Tyr Ile Ser Gly Ser
    850                 855                 860                 
Leu Val Ile His Asn Thr Asp Ile Glu Gln Ser Arg Asn Ala Glu Asn
865                 870                 875                 880 
Glu Ser Pro Lys Gly Gln Ala Ser Ser Asn Gly Cys Ala Ala Leu Lys
                885                 890                 895     
Lys Asp Ser Leu Pro Leu Leu Pro Lys Asn Arg Gly Met Val Ile Val
            900                 905                 910         
Asn Gly Gly Leu Lys Gln Asp Glu Arg Pro Ala Ala Asn Pro Gln Gln
        915                 920                 925             
Glu Asn Ile Ser Gln Asn Pro Gln His Glu Asp Asp His Lys Ser Pro
    930                 935                 940                 
Ser Trp Ile Ser Glu Asn Pro Leu Ala Ala Asn Glu Asn Val Ser Pro
945                 950                 955                 960 
Gly Ile Pro Ser Ala Glu Glu Gln Leu Ser Ser Ile Ala Lys Gly Val
                965                 970                 975     
Asn Gly Ser Ser Gln Ala Pro Thr Ser Gly Lys Tyr Cys Arg Leu Cys
            980                 985                 990         
Asp Ile Gln Phe Asn Asn Leu Ser Asn Phe Ile Thr His Lys Lys Phe
        995                 1000                1005            
Tyr Cys Ser Ser His Ala Ala Glu His Val Lys
    1010                1015                


<210> 2345
<211> 443
<212> PRT
<213> Homo sapiens

<400> 2345
Met Asp Ser Arg Ala Gln Leu Trp Gly Leu Ala Leu Asn Lys Arg Arg
 1               5                  10                  15      
Ala Thr Leu Pro His Pro Gly Gly Ser Thr Asn Leu Lys Ala Asp Pro
            20                  25                  30          
Glu Glu Leu Phe Thr Lys Leu Glu Lys Ile Gly Lys Gly Ser Phe Gly
        35                  40                  45              
Glu Val Phe Lys Gly Ile Asp Asn Arg Thr Gln Lys Val Val Ala Ile
    50                  55                  60                  
Lys Ile Ile Asp Leu Glu Glu Ala Glu Asp Glu Ile Glu Asp Ile Gln
65                  70                  75                  80  
Gln Glu Ile Thr Val Leu Ser Gln Cys Asp Ser Pro Tyr Val Thr Lys
                85                  90                  95      
Tyr Tyr Gly Ser Tyr Leu Lys Asp Thr Lys Leu Trp Ile Ile Met Glu
            100                 105                 110         
Tyr Leu Gly Gly Gly Ser Ala Leu Asp Leu Leu Glu Pro Gly Pro Leu
        115                 120                 125             
Asp Glu Thr Gln Ile Ala Thr Ile Leu Arg Glu Ile Leu Lys Gly Leu
    130                 135                 140                 
Asp Tyr Leu His Ser Glu Lys Lys Ile His Arg Asp Ile Lys Ala Ala
145                 150                 155                 160 
Asn Val Leu Leu Ser Glu His Gly Glu Val Lys Leu Ala Asp Phe Gly
                165                 170                 175     
Val Ala Gly Gln Leu Thr Asp Thr Gln Ile Lys Arg Asn Thr Phe Val
            180                 185                 190         
Gly Thr Pro Phe Trp Met Ala Pro Glu Val Ile Lys Gln Ser Ala Tyr
        195                 200                 205             
Asp Ser Lys Ala Asp Ile Trp Ser Leu Gly Ile Thr Ala Ile Glu Leu
    210                 215                 220                 
Ala Arg Gly Glu Pro Pro His Ser Glu Leu His Pro Met Lys Val Leu
225                 230                 235                 240 
Phe Leu Ile Pro Lys Asn Asn Pro Pro Thr Leu Glu Gly Asn Tyr Ser
                245                 250                 255     
Lys Pro Leu Lys Glu Phe Val Glu Ala Cys Leu Asn Lys Glu Pro Ser
            260                 265                 270         
Phe Arg Pro Thr Ala Lys Glu Leu Leu Lys His Lys Phe Ile Leu Arg
        275                 280                 285             
Asn Ala Lys Lys Thr Ser Tyr Leu Thr Glu Leu Ile Asp Arg Tyr Lys
    290                 295                 300                 
Arg Trp Lys Ala Glu Gln Ser His Asp Asp Ser Ser Ser Glu Asp Ser
305                 310                 315                 320 
Asp Ala Glu Thr Asp Gly Gln Ala Ser Gly Gly Ser Asp Ser Gly Asp
                325                 330                 335     
Trp Ile Phe Thr Ile Arg Glu Lys Asp Pro Lys Asn Leu Glu Asn Gly
            340                 345                 350         
Ala Leu Gln Pro Ser Asp Leu Asp Arg Asn Lys Met Lys Asp Ile Pro
        355                 360                 365             
Lys Arg Pro Phe Ser Gln Cys Leu Ser Thr Ile Ile Ser Pro Leu Phe
    370                 375                 380                 
Ala Glu Leu Lys Glu Lys Ser Gln Ala Cys Gly Gly Asn Leu Gly Ser
385                 390                 395                 400 
Ile Glu Glu Leu Arg Gly Ala Ile Tyr Leu Ala Glu Glu Ala Cys Pro
                405                 410                 415     
Gly Ile Ser Asp Thr Met Val Ala Gln Leu Val Gln Arg Leu Gln Arg
            420                 425                 430         
Tyr Ser Leu Ser Gly Gly Gly Thr Ser Ser His
        435                 440             


<210> 2346
<211> 592
<212> PRT
<213> Homo sapiens

<400> 2346
Met Phe Pro Asp Asn Phe Val Lys Glu Ile Lys Arg Glu Thr Glu Phe
 1               5                  10                  15      
Lys Asp Asp Ser Leu Pro Ile Lys Arg Glu Arg His Gly Asn Val Ala
            20                  25                  30          
Ser Leu Val Gln Arg Ile Ser Thr Tyr Gly Leu Pro Ala Gly Gly Ile
        35                  40                  45              
Gln Pro His Pro Gln Thr Lys Asn Ile Lys Lys Lys Thr Lys Lys Arg
    50                  55                  60                  
Gln Cys Lys Val Leu Phe Glu Tyr Ile Pro Gln Asn Glu Asp Glu Leu
65                  70                  75                  80  
Glu Leu Lys Val Gly Asp Ile Ile Asp Ile Asn Glu Glu Val Glu Glu
                85                  90                  95      
Gly Trp Trp Ser Gly Thr Leu Asn Asn Lys Leu Gly Leu Phe Pro Ser
            100                 105                 110         
Asn Phe Val Lys Glu Leu Glu Val Thr Asp Asp Gly Glu Thr His Glu
        115                 120                 125             
Ala Gln Asp Asp Ser Glu Thr Val Leu Ala Gly Pro Thr Ser Pro Ile
    130                 135                 140                 
Pro Ser Leu Gly Asn Val Ser Glu Thr Ala Ser Gly Ser Val Thr Gln
145                 150                 155                 160 
Pro Lys Lys Ile Arg Gly Ile Gly Phe Gly Asp Ile Phe Lys Glu Gly
                165                 170                 175     
Ser Val Lys Leu Arg Thr Arg Thr Ser Ser Ser Glu Thr Glu Glu Lys
            180                 185                 190         
Lys Pro Glu Lys Pro Leu Ile Leu Gln Ser Leu Gly Pro Lys Thr Gln
        195                 200                 205             
Ser Val Glu Ile Thr Lys Thr Asp Thr Glu Gly Lys Ile Lys Ala Lys
    210                 215                 220                 
Glu Tyr Cys Arg Thr Leu Phe Ala Tyr Glu Gly Thr Asn Glu Asp Glu
225                 230                 235                 240 
Leu Thr Phe Lys Glu Gly Glu Ile Ile His Leu Ile Ser Lys Glu Thr
                245                 250                 255     
Gly Glu Ala Gly Trp Trp Arg Gly Glu Leu Asn Gly Lys Glu Gly Val
            260                 265                 270         
Phe Pro Asp Asn Phe Ala Val Gln Ile Asn Glu Leu Asp Lys Asp Phe
        275                 280                 285             
Pro Lys Pro Lys Lys Pro Pro Pro Pro Ala Lys Ala Pro Ala Pro Lys
    290                 295                 300                 
Pro Glu Leu Ile Ala Ala Glu Lys Lys Tyr Phe Ser Leu Lys Pro Glu
305                 310                 315                 320 
Glu Lys Asp Glu Lys Ser Thr Leu Glu Gln Lys Pro Ser Lys Pro Ala
                325                 330                 335     
Ala Pro Gln Val Pro Pro Lys Lys Pro Thr Pro Pro Thr Lys Ala Ser
            340                 345                 350         
Asn Leu Leu Arg Ser Ser Gly Thr Val Tyr Pro Lys Arg Pro Glu Lys
        355                 360                 365             
Pro Val Pro Pro Pro Pro Pro Ile Ala Lys Ile Asn Gly Glu Val Ser
    370                 375                 380                 
Ser Ile Ser Ser Lys Phe Glu Thr Glu Pro Val Ser Lys Leu Lys Leu
385                 390                 395                 400 
Asp Ser Glu Gln Leu Pro Leu Arg Pro Lys Ser Val Asp Phe Asp Ser
                405                 410                 415     
Leu Thr Val Arg Thr Ser Lys Glu Thr Asp Val Val Asn Phe Asp Asp
            420                 425                 430         
Ile Ala Ser Ser Glu Asn Leu Leu His Leu Thr Ala Asn Arg Pro Lys
        435                 440                 445             
Met Pro Gly Arg Arg Leu Pro Gly Arg Phe Asn Gly Gly His Ser Pro
    450                 455                 460                 
Thr His Ser Pro Glu Lys Ile Leu Lys Leu Pro Lys Glu Glu Asp Ser
465                 470                 475                 480 
Ala Asn Leu Lys Pro Ser Glu Leu Lys Lys Asp Thr Cys Tyr Ser Pro
                485                 490                 495     
Lys Pro Ser Val Tyr Leu Ser Thr Pro Ser Ser Ala Ser Lys Ala Asn
            500                 505                 510         
Thr Thr Ala Phe Leu Thr Pro Leu Glu Ile Lys Ala Lys Val Glu Thr
        515                 520                 525             
Asp Asp Val Lys Lys Asn Ser Leu Asp Glu Leu Arg Ala Gln Ile Ile
    530                 535                 540                 
Glu Leu Leu Cys Ile Val Glu Ala Leu Lys Lys Asp His Gly Lys Glu
545                 550                 555                 560 
Leu Glu Lys Leu Arg Lys Asp Leu Glu Glu Glu Lys Thr Met Arg Ser
                565                 570                 575     
Asn Leu Glu Met Glu Ile Glu Lys Leu Lys Lys Ala Val Leu Ser Ser
            580                 585                 590         


<210> 2347
<211> 1130
<212> PRT
<213> Homo sapiens

<400> 2347
Met Ala His Ala Gly Gly Gly Ser Gly Gly Ser Gly Ala Gly Gly Pro
 1               5                  10                  15      
Ala Gly Arg Gly Leu Ser Gly Ala Arg Trp Gly Arg Ser Gly Ser Ala
            20                  25                  30          
Gly His Glu Lys Leu Pro Val His Val Glu Asp Ala Leu Thr Tyr Leu
        35                  40                  45              
Asp Gln Val Lys Ile Arg Phe Gly Ser Asp Pro Ala Thr Tyr Asn Gly
    50                  55                  60                  
Phe Leu Glu Ile Met Lys Glu Phe Lys Ser Gln Ser Ile Asp Thr Pro
65                  70                  75                  80  
Gly Val Ile Arg Arg Val Ser Gln Leu Phe His Glu His Pro Asp Leu
                85                  90                  95      
Ile Val Gly Phe Asn Ala Phe Leu Pro Leu Gly Tyr Arg Ile Asp Ile
            100                 105                 110         
Pro Lys Asn Gly Lys Leu Asn Ile Gln Ser Pro Leu Thr Ser Gln Glu
        115                 120                 125             
Asn Ser His Asn His Gly Asp Gly Ala Glu Asp Phe Lys Gln Gln Val
    130                 135                 140                 
Pro Tyr Lys Glu Asp Lys Pro Gln Val Pro Leu Glu Ser Asp Ser Val
145                 150                 155                 160 
Glu Phe Asn Asn Ala Ile Ser Tyr Val Asn Lys Ile Lys Thr Arg Phe
                165                 170                 175     
Leu Asp His Pro Glu Ile Tyr Arg Ser Phe Leu Glu Ile Leu His Thr
            180                 185                 190         
Tyr Gln Lys Glu Gln Leu Asn Thr Arg Gly Arg Pro Phe Arg Gly Met
        195                 200                 205             
Ser Glu Glu Glu Val Phe Thr Glu Val Ala Asn Leu Phe Arg Gly Gln
    210                 215                 220                 
Glu Asp Leu Leu Ser Glu Phe Gly Gln Phe Leu Pro Glu Ala Lys Arg
225                 230                 235                 240 
Ser Leu Phe Thr Gly Asn Gly Pro Cys Glu Met His Ser Val Gln Lys
                245                 250                 255     
Asn Glu His Asp Lys Thr Pro Glu His Ser Arg Lys Arg Ser Arg Pro
            260                 265                 270         
Ser Leu Leu Arg Pro Val Ser Ala Pro Ala Lys Lys Lys Met Lys Leu
        275                 280                 285             
Arg Gly Thr Lys Asp Leu Ser Ile Ala Ala Val Gly Lys Tyr Gly Thr
    290                 295                 300                 
Leu Gln Glu Phe Ser Phe Phe Asp Lys Val Arg Arg Val Leu Lys Ser
305                 310                 315                 320 
Gln Glu Val Tyr Glu Asn Phe Leu Arg Cys Ile Ala Leu Phe Asn Gln
                325                 330                 335     
Glu Leu Val Ser Gly Ser Glu Leu Leu Gln Leu Val Ser Pro Phe Leu
            340                 345                 350         
Gly Lys Phe Pro Glu Leu Phe Ala Gln Phe Lys Ser Phe Leu Gly Val
        355                 360                 365             
Lys Glu Leu Ser Phe Ala Pro Pro Met Ser Asp Arg Ser Gly Asp Gly
    370                 375                 380                 
Ile Ser Arg Glu Ile Asp Tyr Ala Ser Cys Lys Arg Ile Gly Ser Ser
385                 390                 395                 400 
Tyr Arg Ala Leu Pro Lys Thr Tyr Gln Gln Pro Lys Cys Ser Gly Arg
                405                 410                 415     
Thr Ala Ile Cys Lys Glu Val Leu Asn Asp Thr Trp Val Ser Phe Pro
            420                 425                 430         
Ser Trp Ser Glu Asp Ser Thr Phe Val Ser Ser Lys Lys Thr Pro Tyr
        435                 440                 445             
Glu Glu Gln Leu His Arg Cys Glu Asp Glu Arg Phe Glu Leu Asp Val
    450                 455                 460                 
Val Leu Glu Thr Asn Leu Ala Thr Ile Arg Val Leu Glu Ser Val Gln
465                 470                 475                 480 
Lys Lys Leu Ser Arg Met Ala Pro Glu Asp Gln Glu Lys Phe Arg Leu
                485                 490                 495     
Asp Asp Ser Leu Gly Gly Thr Ser Glu Val Ile Gln Arg Arg Ala Ile
            500                 505                 510         
Tyr Arg Ile Tyr Gly Asp Lys Ala Pro Glu Ile Ile Glu Ser Leu Lys
        515                 520                 525             
Lys Asn Pro Val Thr Ala Val Pro Val Val Leu Lys Arg Leu Lys Ala
    530                 535                 540                 
Lys Glu Glu Glu Trp Arg Glu Ala Gln Gln Gly Phe Asn Lys Ile Trp
545                 550                 555                 560 
Arg Glu Gln Tyr Glu Lys Ala Tyr Leu Lys Ser Leu Asp His Gln Ala
                565                 570                 575     
Val Asn Phe Lys Gln Asn Asp Thr Lys Ala Leu Arg Ser Lys Ser Leu
            580                 585                 590         
Leu Asn Glu Ile Glu Ser Val Tyr Asp Glu His Gln Glu Gln His Ser
        595                 600                 605             
Glu Gly Arg Ser Ala Pro Ser Ser Glu Pro His Leu Ile Phe Val Tyr
    610                 615                 620                 
Glu Asp Arg Gln Ile Leu Glu Asp Ala Ala Ala Leu Ile Ser Tyr Tyr
625                 630                 635                 640 
Val Lys Arg Gln Pro Ala Ile Gln Lys Glu Asp Gln Gly Thr Ile His
                645                 650                 655     
Gln Leu Leu His Gln Phe Val Pro Ser Leu Phe Phe Ser Gln Gln Leu
            660                 665                 670         
Asp Leu Gly Ala Ser Glu Glu Ser Ala Asp Glu Asp Arg Asp Ser Pro
        675                 680                 685             
Gln Gly Gln Thr Thr Asp Pro Ser Glu Arg Lys Lys Pro Ala Pro Gly
    690                 695                 700                 
Pro His Ser Ser Pro Pro Glu Glu Lys Gly Ala Phe Gly Asp Ala Pro
705                 710                 715                 720 
Ala Thr Glu Gln Pro Pro Leu Pro Pro Pro Ala Pro His Lys Pro Leu
                725                 730                 735     
Asp Asp Val Tyr Ser Leu Phe Phe Ala Asn Asn Asn Trp Tyr Phe Phe
            740                 745                 750         
Leu Arg Leu His Gln Thr Leu Cys Ser Arg Leu Leu Lys Ile Tyr Arg
        755                 760                 765             
Gln Ala Gln Lys Gln Leu Leu Glu Tyr Arg Thr Glu Lys Glu Arg Glu
    770                 775                 780                 
Lys Leu Leu Cys Glu Gly Arg Arg Glu Lys Gly Ser Asp Pro Ala Met
785                 790                 795                 800 
Glu Leu Arg Leu Lys Gln Pro Ser Glu Val Glu Leu Glu Glu Tyr Tyr
                805                 810                 815     
Pro Ala Phe Leu Asp Met Val Arg Ser Leu Leu Glu Gly Ser Ile Asp
            820                 825                 830         
Pro Thr Gln Tyr Glu Asp Thr Leu Arg Glu Met Phe Thr Ile His Ala
        835                 840                 845             
Tyr Val Gly Phe Thr Met Asp Lys Leu Val Gln Asn Ile Ala Arg Gln
    850                 855                 860                 
Leu His His Leu Val Ser Asp Asp Val Cys Leu Lys Val Val Glu Leu
865                 870                 875                 880 
Tyr Leu Asn Glu Lys Lys Arg Gly Ala Ala Gly Gly Asn Leu Ser Ser
                885                 890                 895     
Arg Cys Val Arg Ala Ala Arg Glu Thr Ser Tyr Gln Trp Lys Ala Glu
            900                 905                 910         
Arg Cys Met Ala Asp Glu Asn Cys Phe Lys Val Met Phe Leu Gln Arg
        915                 920                 925             
Lys Gly Gln Val Ile Met Thr Ile Glu Leu Leu Asp Thr Glu Glu Ala
    930                 935                 940                 
Gln Thr Glu Asp Pro Val Glu Val Gln His Leu Ala Arg Tyr Val Glu
945                 950                 955                 960 
Gln Tyr Val Gly Thr Glu Gly Ala Ser Ser Ser Pro Thr Glu Gly Phe
                965                 970                 975     
Leu Leu Lys Pro Val Phe Leu Gln Arg Asn Leu Lys Lys Phe Arg Arg
            980                 985                 990         
Arg Trp Gln Ser Glu Gln Ala Arg Ala Leu Arg Gly Glu Ala Arg Ser
        995                 1000                1005            
Ser Trp Lys Arg Leu Val Gly Val Glu Ser Ala Cys Asp Val Asp Cys
    1010                1015                1020                
Arg Phe Lys Leu Ser Thr His Lys Met Val Phe Ile Val Asn Ser Glu
1025                1030                1035                1040
Asp Tyr Met Tyr Arg Arg Gly Thr Leu Cys Arg Ala Lys Gln Val Gln
                1045                1050                1055    
Pro Leu Val Leu Leu Arg His His Gln His Phe Glu Glu Trp His Ser
            1060                1065                1070        
Arg Trp Leu Glu Asp Asn Val Thr Val Glu Ala Ala Ser Leu Val Gln
        1075                1080                1085            
Asp Trp Leu Met Gly Glu Glu Asp Glu Asp Met Val Pro Cys Lys Thr
    1090                1095                1100                
Leu Cys Glu Thr Val His Val His Gly Leu Pro Val Thr Arg Tyr Arg
1105                1110                1115                1120
Val Gln Tyr Ser Arg Arg Pro Ala Ser Pro
                1125                1130


<210> 2348
<211> 466
<212> PRT
<213> Homo sapiens

<400> 2348
Met Ala Leu Leu Thr Ala Ala Ala Arg Leu Leu Gly Thr Lys Asn Ala
 1               5                  10                  15      
Ser Cys Leu Val Leu Ala Ala Arg His Ala Ser Ala Ser Ser Thr Asn
            20                  25                  30          
Leu Lys Asp Ile Leu Ala Asp Leu Ile Pro Lys Glu Gln Ala Arg Ile
        35                  40                  45              
Lys Thr Phe Arg Gln Gln His Gly Lys Thr Val Val Gly Gln Ile Thr
    50                  55                  60                  
Val Asp Met Met Tyr Gly Gly Met Arg Gly Met Lys Gly Leu Val Tyr
65                  70                  75                  80  
Glu Thr Ser Val Leu Asp Pro Asp Glu Gly Ile Arg Phe Arg Gly Phe
                85                  90                  95      
Ser Ile Pro Glu Cys Gln Lys Leu Leu Pro Lys Ala Lys Gly Gly Glu
            100                 105                 110         
Glu Pro Leu Pro Glu Gly Leu Phe Trp Leu Leu Val Thr Gly His Ile
        115                 120                 125             
Pro Thr Glu Glu Gln Val Ser Trp Leu Ser Lys Glu Trp Ala Lys Arg
    130                 135                 140                 
Ala Ala Leu Pro Ser His Val Val Thr Met Leu Asp Asn Phe Pro Thr
145                 150                 155                 160 
Asn Leu His Pro Met Ser Gln Leu Ser Ala Ala Val Thr Ala Leu Asn
                165                 170                 175     
Ser Glu Ser Asn Phe Ala Arg Ala Tyr Ala Gln Gly Ile Ser Arg Thr
            180                 185                 190         
Lys Tyr Trp Glu Leu Ile Tyr Glu Asp Ser Met Asp Leu Ile Ala Lys
        195                 200                 205             
Leu Pro Cys Val Ala Ala Lys Ile Tyr Arg Asn Leu Tyr Arg Glu Gly
    210                 215                 220                 
Ser Gly Ile Gly Ala Ile Asp Ser Asn Leu Asp Trp Ser His Asn Phe
225                 230                 235                 240 
Thr Asn Met Leu Gly Tyr Thr Asp His Gln Phe Thr Glu Leu Thr Arg
                245                 250                 255     
Leu Tyr Leu Thr Ile His Ser Asp His Glu Gly Gly Asn Val Ser Ala
            260                 265                 270         
His Thr Ser His Leu Val Gly Ser Ala Leu Ser Asp Pro Tyr Leu Ser
        275                 280                 285             
Phe Ala Ala Ala Met Asn Gly Leu Ala Gly Pro Leu His Gly Leu Ala
    290                 295                 300                 
Asn Gln Glu Val Leu Val Trp Leu Thr Gln Leu Gln Lys Glu Val Gly
305                 310                 315                 320 
Lys Asp Val Ser Asp Glu Lys Leu Arg Asp Tyr Ile Trp Asn Thr Leu
                325                 330                 335     
Asn Ser Gly Arg Val Val Pro Gly Tyr Gly His Ala Val Leu Arg Lys
            340                 345                 350         
Thr Asp Pro Arg Tyr Thr Cys Gln Arg Glu Phe Ala Leu Lys His Leu
        355                 360                 365             
Pro Asn Asp Pro Met Phe Lys Leu Val Ala Gln Leu Tyr Lys Ile Val
    370                 375                 380                 
Pro Asn Val Leu Leu Glu Gln Gly Lys Ala Lys Asn Pro Trp Pro Asn
385                 390                 395                 400 
Val Asp Ala His Ser Gly Val Leu Leu Gln Tyr Tyr Gly Met Thr Glu
                405                 410                 415     
Met Asn Tyr Tyr Thr Val Leu Phe Gly Val Ser Arg Ala Leu Gly Val
            420                 425                 430         
Leu Ala Gln Leu Ile Trp Ser Arg Ala Leu Gly Phe Pro Leu Glu Arg
        435                 440                 445             
Pro Lys Ser Met Ser Thr Glu Gly Leu Met Lys Phe Val Asp Ser Lys
    450                 455                 460                 
Ser Gly
465     


<210> 2349
<211> 843
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 293, 294, 295, 296, 297, 298, 299, 300, 301, 302, 303, 304,
305, 306, 307, 308, 309, 310, 311, 312, 313, 314, 315, 316,
317, 318, 319, 320, 321, 322, 323, 324, 325, 326, 327, 328,
329, 330, 331, 332, 333, 334, 335, 336, 337, 338, 339
<223> Xaa = Any Amino Acid

<221> VARIANT        
<222> 340, 341, 342, 343
<223> Xaa = Any Amino Acid

<400> 2349
Met Cys Cys Asn Lys Gln Val Ile Val Ile Asp Lys Ile Lys Ser Ala
 1               5                  10                  15      
Ser Ile Ala Asp Arg Cys Gly Ala Leu His Val Gly Asp His Ile Leu
            20                  25                  30          
Ser Ile Asp Gly Thr Ser Met Glu Tyr Cys Thr Leu Ala Glu Ala Thr
        35                  40                  45              
Gln Phe Leu Ala Asn Thr Thr Asp Gln Val Lys Leu Glu Ile Leu Pro
    50                  55                  60                  
His His Gln Thr Arg Leu Ala Leu Lys Gly Pro Asp His Val Lys Ile
65                  70                  75                  80  
Gln Arg Ser Asp Arg Gln Leu Thr Trp Asp Ser Trp Ala Ser Asn His
                85                  90                  95      
Ser Ser Leu His Thr Asn His His Tyr Asn Thr Tyr His Pro Asp His
            100                 105                 110         
Cys Arg Val Pro Ala Leu Thr Phe Pro Lys Ala Pro Pro Pro Asn Ser
        115                 120                 125             
Pro Pro Ala Leu Val Ser Ser Ser Phe Ser Pro Thr Ser Met Ser Ala
    130                 135                 140                 
Tyr Ser Leu Ser Ser Leu Asn Met Gly Thr Leu Pro Arg Ser Leu Tyr
145                 150                 155                 160 
Ser Thr Ser Pro Arg Gly Thr Met Met Arg Arg Arg Leu Lys Lys Lys
                165                 170                 175     
Asp Phe Lys Ser Ser Leu Ser Leu Ala Ser Ser Thr Val Gly Leu Ala
            180                 185                 190         
Gly Gln Val Val His Thr Glu Thr Thr Glu Val Val Leu Thr Ala Asp
        195                 200                 205             
Pro Val Thr Gly Phe Gly Ile Gln Leu Gln Gly Ser Val Phe Ala Thr
    210                 215                 220                 
Glu Thr Leu Ser Ser Pro Pro Leu Ile Ser Tyr Ile Glu Ala Asp Ser
225                 230                 235                 240 
Pro Ala Glu Arg Cys Gly Val Leu Gln Ile Gly Asp Arg Val Met Ala
                245                 250                 255     
Ile Asn Gly Ile Pro Thr Glu Asp Ser Thr Phe Glu Glu Ala Ser Gln
            260                 265                 270         
Leu Leu Arg Asp Ser Ser Ile Thr Ser Lys Val Thr Leu Glu Ile Glu
        275                 280                 285             
Phe Asp Val Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    290                 295                 300                 
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
305                 310                 315                 320 
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
                325                 330                 335     
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Thr Gly Thr Leu Glu Leu Gly Asp Lys
            340                 345                 350         
Leu Leu Ala Ile Asp Asn Ile Arg Leu Asp Asn Cys Ser Met Glu Asp
        355                 360                 365             
Ala Val Gln Ile Leu Gln Gln Cys Glu Asp Leu Val Lys Leu Lys Ile
    370                 375                 380                 
Arg Lys Asp Glu Asp Asn Ser Asp Glu Gln Glu Ser Ser Gly Ala Ile
385                 390                 395                 400 
Ile Tyr Thr Val Glu Leu Lys Arg Tyr Gly Gly Pro Leu Gly Ile Thr
                405                 410                 415     
Ile Ser Gly Thr Glu Glu Pro Phe Asp Pro Ile Ile Ile Ser Ser Leu
            420                 425                 430         
Thr Lys Gly Gly Leu Ala Glu Arg Thr Gly Ala Ile His Ile Gly Asp
        435                 440                 445             
Arg Ile Leu Ala Ile Asn Ser Ser Ser Leu Lys Gly Lys Pro Leu Ser
    450                 455                 460                 
Glu Ala Ile His Leu Leu Gln Met Ala Gly Glu Thr Val Thr Leu Lys
465                 470                 475                 480 
Ile Lys Lys Gln Thr Asp Ala Gln Ser Ala Ser Ser Pro Lys Lys Phe
                485                 490                 495     
Pro Ile Ser Ser His Leu Ser Asp Leu Gly Asp Val Glu Glu Asp Ser
            500                 505                 510         
Ser Pro Ala Gln Lys Pro Gly Lys Leu Ser Asp Met Tyr Pro Ser Thr
        515                 520                 525             
Val Pro Ser Val Asp Ser Ala Val Asp Ser Trp Asp Gly Ser Ala Ile
    530                 535                 540                 
Asp Thr Ser Tyr Gly Thr Glu Gly Thr Ser Phe Gln Ala Ser Gly Tyr
545                 550                 555                 560 
Asn Phe Asn Thr Tyr Asp Trp Arg Ser Pro Lys Gln Arg Gly Ser Leu
                565                 570                 575     
Ser Pro Val Thr Lys Pro Arg Ser Gln Thr Tyr Pro Asp Val Gly Leu
            580                 585                 590         
Ser Tyr Glu Asp Trp Asp Arg Ser Thr Ala Ser Gly Phe Ala Gly Ala
        595                 600                 605             
Ala Asp Ser Ala Glu Thr Glu Gln Glu Glu Asn Phe Trp Ser Gln Ala
    610                 615                 620                 
Leu Glu Asp Leu Glu Thr Cys Gly Gln Ser Gly Ile Leu Arg Glu Leu
625                 630                 635                 640 
Glu Ala Thr Ile Met Ser Gly Ser Thr Met Ser Leu Asn His Glu Ala
                645                 650                 655     
Pro Thr Pro Arg Ser Gln Leu Gly Arg Gln Ala Ser Phe Gln Glu Arg
            660                 665                 670         
Ser Ser Ser Arg Pro His Tyr Ser Gln Thr Thr Arg Ser Asn Thr Leu
        675                 680                 685             
Pro Ser Asp Val Gly Arg Lys Ser Val Thr Leu Arg Lys Met Lys Gln
    690                 695                 700                 
Glu Ile Lys Glu Ile Met Ser Pro Thr Pro Val Glu Leu His Lys Val
705                 710                 715                 720 
Thr Leu Tyr Lys Asp Ser Asp Met Glu Asp Phe Gly Phe Ser Val Ala
                725                 730                 735     
Asp Gly Leu Leu Glu Lys Gly Val Tyr Val Lys Asn Ile Arg Pro Ala
            740                 745                 750         
Gly Pro Gly Asp Leu Gly Gly Leu Lys Pro Tyr Asp Arg Leu Leu Gln
        755                 760                 765             
Val Asn His Val Arg Thr Arg Asp Phe Asp Cys Cys Leu Val Val Pro
    770                 775                 780                 
Leu Ile Ala Glu Ser Gly Asn Lys Leu Asp Leu Val Ile Ser Arg Asn
785                 790                 795                 800 
Pro Leu Ala Ser Gln Lys Ser Ile Asp Gln Gln Ser Leu Pro Gly Asp
                805                 810                 815     
Trp Ser Glu Gln Asn Ser Ala Phe Phe Gln Gln Pro Ser His Gly Gly
            820                 825                 830         
Asn Leu Glu Thr Arg Glu Pro Thr Asn Thr Leu
        835                 840             


<210> 2350
<211> 89
<212> PRT
<213> Homo sapiens

<400> 2350
Met Ala Ala Pro Lys Val Arg Phe Met Thr Lys Ile Tyr His Pro Asn
 1               5                  10                  15      
Val Asp Lys Leu Gly Arg Ile Cys Leu Asp Ile Leu Lys Asp Lys Trp
            20                  25                  30          
Ser Pro Ala Leu Gln Ile Arg Thr Val Leu Leu Ser Ile Gln Ala Leu
        35                  40                  45              
Leu Ser Ala Pro Asn Pro Asp Asp Pro Leu Ala Asn Asp Val Ala Glu
    50                  55                  60                  
Gln Trp Lys Thr Asn Glu Ala Gln Ala Ile Glu Thr Ala Arg Ala Trp
65                  70                  75                  80  
Thr Arg Leu Tyr Ala Met Asn Asn Ile
                85                  


<210> 2351
<211> 148
<212> PRT
<213> Homo sapiens

<400> 2351
Met Lys Val Arg Lys Cys Ser Thr Pro Glu Glu Ile Lys Lys Arg Lys
 1               5                  10                  15      
Lys Ala Val Ile Phe Cys Leu Ser Ala Asp Lys Lys Cys Ile Ile Val
            20                  25                  30          
Glu Glu Gly Lys Glu Ile Leu Val Gly Asp Val Gly Val Thr Ile Thr
        35                  40                  45              
Asp Pro Phe Lys His Phe Val Gly Met Leu Pro Glu Lys Asp Cys Arg
    50                  55                  60                  
Tyr Ala Leu Tyr Asp Ala Ser Phe Glu Thr Lys Glu Ser Arg Lys Glu
65                  70                  75                  80  
Glu Leu Met Phe Phe Leu Trp Ala Pro Glu Leu Ala Pro Leu Lys Ser
                85                  90                  95      
Lys Met Ile Tyr Ala Ser Ser Lys Asp Ala Ile Lys Lys Lys Phe Gln
            100                 105                 110         
Gly Ile Lys His Glu Cys Gln Ala Asn Gly Pro Glu Asp Leu Asn Arg
        115                 120                 125             
Ala Cys Ile Ala Glu Lys Leu Gly Gly Ser Leu Ile Val Ala Phe Glu
    130                 135                 140                 
Gly Cys Pro Val
145             


<210> 2352
<211> 260
<212> PRT
<213> Homo sapiens

<400> 2352
Met Glu Lys Cys Glu Ala Ala Ala Lys Asp Ile Arg Gly Glu Thr Leu
 1               5                  10                  15      
Asn His His Val Asn Ala Arg His Leu Asp Leu Ala Ser Leu Lys Ser
            20                  25                  30          
Ile Arg Glu Phe Ala Ala Lys Ile Ile Glu Glu Glu Glu Arg Val Asp
        35                  40                  45              
Ile Leu Ile Asn Asn Ala Gly Val Met Arg Cys Pro His Trp Thr Thr
    50                  55                  60                  
Glu Asp Gly Phe Glu Met Gln Phe Gly Val Asn His Leu Gly His Phe
65                  70                  75                  80  
Leu Leu Thr Asn Leu Leu Leu Asp Lys Leu Lys Ala Ser Ala Pro Ser
                85                  90                  95      
Arg Ile Ile Asn Leu Ser Ser Leu Ala His Val Ala Gly His Ile Asp
            100                 105                 110         
Phe Asp Asp Leu Asn Trp Gln Thr Arg Lys Tyr Asn Thr Lys Ala Ala
        115                 120                 125             
Tyr Cys Gln Ser Lys Leu Ala Ile Val Leu Phe Thr Lys Glu Leu Ser
    130                 135                 140                 
Arg Arg Leu Gln Gly Ser Gly Val Thr Val Asn Ala Leu His Pro Gly
145                 150                 155                 160 
Val Ala Arg Thr Glu Leu Gly Arg His Thr Gly Ile His Gly Ser Thr
                165                 170                 175     
Phe Ser Ser Thr Thr Leu Gly Pro Ile Phe Trp Leu Leu Val Lys Ser
            180                 185                 190         
Pro Glu Leu Ala Ala Gln Pro Ser Thr Tyr Leu Ala Val Ala Glu Glu
        195                 200                 205             
Leu Ala Asp Val Ser Gly Lys Tyr Phe Asp Gly Leu Lys Gln Lys Ala
    210                 215                 220                 
Pro Ala Pro Glu Ala Glu Asp Glu Glu Val Ala Arg Arg Leu Trp Ala
225                 230                 235                 240 
Glu Ser Ala Arg Leu Val Gly Leu Glu Ala Pro Ser Val Arg Glu Gln
                245                 250                 255     
Pro Leu Pro Arg
            260 


<210> 2353
<211> 210
<212> PRT
<213> Homo sapiens

<400> 2353
Met Ala Asp Gly Ser Ser Asp Ala Ala Arg Glu Pro Arg Pro Ala Pro
 1               5                  10                  15      
Ala Pro Ile Arg Arg Arg Ser Ser Asn Tyr Arg Ala Tyr Ala Thr Glu
            20                  25                  30          
Pro His Ala Lys Lys Lys Ser Lys Ile Ser Ala Ser Arg Lys Leu Gln
        35                  40                  45              
Leu Lys Thr Leu Leu Leu Gln Ile Ala Lys Gln Glu Leu Glu Arg Glu
    50                  55                  60                  
Ala Glu Glu Arg Arg Gly Glu Lys Gly Arg Ala Leu Ser Thr Arg Cys
65                  70                  75                  80  
Gln Pro Leu Glu Leu Ala Gly Leu Gly Phe Ala Glu Leu Gln Asp Leu
                85                  90                  95      
Cys Arg Gln Leu His Ala Arg Val Asp Lys Val Asp Glu Glu Arg Tyr
            100                 105                 110         
Asp Ile Glu Ala Lys Val Thr Lys Asn Ile Thr Glu Ile Ala Asp Leu
        115                 120                 125             
Thr Gln Lys Ile Phe Asp Leu Arg Gly Lys Phe Lys Arg Pro Thr Leu
    130                 135                 140                 
Arg Arg Val Arg Ile Ser Ala Asp Ala Met Met Gln Ala Leu Leu Gly
145                 150                 155                 160 
Ala Arg Ala Lys Glu Ser Leu Asp Leu Arg Ala His Leu Lys Gln Val
                165                 170                 175     
Lys Lys Glu Asp Thr Glu Lys Glu Asn Arg Glu Val Gly Asp Trp Arg
            180                 185                 190         
Lys Asn Ile Asp Ala Leu Ser Gly Met Glu Gly Arg Lys Lys Lys Phe
        195                 200                 205             
Glu Ser
    210 


<210> 2354
<211> 407
<212> PRT
<213> Homo sapiens

<400> 2354
Met Cys Trp Leu Tyr Ala Leu Glu Val Val Glu Arg Glu Cys Trp Val
 1               5                  10                  15      
Ser Pro Gly Asp Leu Ser Ser Asp Gly Leu Leu Phe Arg Leu Gly Pro
            20                  25                  30          
Pro Lys Pro Pro Thr Glu Leu Glu Pro Glu Pro Glu Ile Glu Gly Leu
        35                  40                  45              
Leu Thr Pro Val Leu Glu Ala Gly Asp Val Asp Glu Gly Pro Val Ala
    50                  55                  60                  
Arg Pro Leu Ser Pro Thr Arg Leu Gln Pro Ala Leu Pro Pro Glu Ala
65                  70                  75                  80  
Gln Ser Val Pro Glu Leu Glu Glu Val Ala Arg Val Leu Ala Glu Ile
                85                  90                  95      
Pro Arg Pro Leu Lys Arg Arg Gly Ser Met Glu Gln Ala Pro Ala Val
            100                 105                 110         
Ala Leu Pro Pro Thr His Lys Lys Gln Tyr Gln Gln Ile Ile Ser Arg
        115                 120                 125             
Leu Phe His Arg His Gly Gly Pro Gly Pro Gly Gly Pro Glu Pro Glu
    130                 135                 140                 
Leu Ser Pro Ile Thr Glu Gly Ser Glu Ala Arg Ala Gly Pro Pro Ala
145                 150                 155                 160 
Pro Ala Pro Pro Ala Pro Ile Pro Pro Pro Ala Pro Ser Gln Ser Ser
                165                 170                 175     
Pro Pro Glu Gln Pro Gln Ser Met Glu Met Arg Ser Val Leu Arg Lys
            180                 185                 190         
Ala Gly Ser Pro Arg Lys Ala Arg Arg Ala Arg Leu Asn Pro Leu Val
        195                 200                 205             
Leu Leu Leu Asp Ala Ala Leu Thr Gly Glu Leu Glu Val Val Gln Gln
    210                 215                 220                 
Ala Val Lys Glu Met Asn Asp Pro Ser Gln Pro Asn Glu Glu Gly Ile
225                 230                 235                 240 
Thr Ala Leu His Asn Ala Ile Cys Gly Ala Asn Tyr Ser Ile Val Asp
                245                 250                 255     
Phe Leu Ile Thr Ala Gly Ala Asn Val Asn Ser Pro Asp Ser His Gly
            260                 265                 270         
Trp Thr Pro Leu His Cys Ala Ala Ser Cys Asn Asp Thr Val Ile Cys
        275                 280                 285             
Met Ala Leu Val Gln His Gly Ala Ala Ile Phe Ala Thr Thr Leu Ser
    290                 295                 300                 
Asp Gly Ala Thr Ala Phe Glu Lys Cys Asp Pro Tyr Arg Glu Gly Tyr
305                 310                 315                 320 
Ala Asp Cys Ala Thr Tyr Leu Ala Asp Val Glu Gln Ser Met Gly Leu
                325                 330                 335     
Met Asn Ser Gly Ala Val Tyr Ala Leu Trp Asp Tyr Ser Ala Glu Phe
            340                 345                 350         
Gly Asp Glu Leu Ser Phe Arg Glu Gly Glu Ser Val Thr Val Leu Arg
        355                 360                 365             
Arg Asp Gly Pro Glu Glu Thr Asp Trp Trp Trp Ala Ala Leu His Gly
    370                 375                 380                 
Gln Glu Gly Tyr Val Pro Arg Asn Tyr Phe Gly Leu Phe Pro Arg Val
385                 390                 395                 400 
Lys Pro Gln Arg Ser Lys Val
                405         


<210> 2355
<211> 527
<212> PRT
<213> Homo sapiens

<400> 2355
Met Ala Gln Thr Leu Gln Met Glu Ile Pro Asn Phe Gly Asn Ser Ile
 1               5                  10                  15      
Leu Glu Cys Leu Asn Glu Gln Arg Leu Gln Gly Leu Tyr Cys Asp Val
            20                  25                  30          
Ser Val Val Val Lys Gly His Ala Phe Lys Ala His Arg Ala Val Leu
        35                  40                  45              
Ala Ala Ser Ser Ser Tyr Phe Arg Asp Leu Phe Asn Asn Ser Arg Ser
    50                  55                  60                  
Ala Val Val Glu Leu Pro Ala Ala Val Gln Pro Gln Ser Phe Gln Gln
65                  70                  75                  80  
Ile Leu Ser Phe Cys Tyr Thr Gly Arg Leu Ser Met Asn Val Gly Asp
                85                  90                  95      
Gln Phe Leu Leu Met Tyr Thr Ala Gly Phe Leu Gln Ile Gln Glu Ile
            100                 105                 110         
Met Glu Lys Gly Thr Glu Phe Phe Leu Lys Val Ser Ser Pro Ser Cys
        115                 120                 125             
Asp Ser Gln Gly Leu His Ala Glu Glu Ala Pro Ser Ser Glu Pro Gln
    130                 135                 140                 
Ser Pro Val Ala Gln Thr Ser Gly Trp Pro Ala Cys Ser Thr Pro Leu
145                 150                 155                 160 
Pro Leu Val Ser Arg Val Lys Thr Glu Gln Gln Glu Ser Asp Ser Val
                165                 170                 175     
Gln Cys Met Pro Val Ala Lys Arg Leu Trp Asp Ser Gly Gln Lys Glu
            180                 185                 190         
Ala Gly Gly Gly Gly Asn Gly Ser Arg Lys Met Ala Lys Phe Ser Thr
        195                 200                 205             
Pro Asp Leu Ala Ala Asn Arg Pro His Gln Pro Pro Pro Pro Gln Gln
    210                 215                 220                 
Ala Pro Val Val Ala Ala Ala Gln Pro Ala Val Ala Ala Gly Ala Gly
225                 230                 235                 240 
Gln Pro Ala Gly Gly Val Ala Ala Ala Gly Gly Val Val Ser Gly Pro
                245                 250                 255     
Ser Thr Ser Glu Arg Thr Ser Pro Gly Thr Ser Ser Ala Tyr Thr Ser
            260                 265                 270         
Asp Ser Pro Gly Ser Tyr His Asn Glu Glu Asp Glu Glu Glu Asp Gly
        275                 280                 285             
Gly Glu Glu Gly Met Asp Glu Gln Tyr Arg Gln Ile Cys Asn Met Tyr
    290                 295                 300                 
Thr Met Tyr Ser Met Met Asn Val Gly Gln Thr Ala Glu Lys Val Glu
305                 310                 315                 320 
Ala Leu Pro Glu Gln Val Ala Pro Glu Ser Arg Asn Arg Ile Arg Val
                325                 330                 335     
Arg Gln Asp Leu Ala Ser Leu Pro Ala Glu Leu Ile Asn Gln Ile Gly
            340                 345                 350         
Asn Arg Cys His Pro Lys Leu Tyr Asp Glu Gly Asp Pro Ser Glu Lys
        355                 360                 365             
Leu Glu Leu Val Thr Gly Thr Asn Val Tyr Ile Thr Arg Ala Gln Leu
    370                 375                 380                 
Met Asn Cys His Val Ser Ala Gly Thr Arg His Lys Val Leu Leu Arg
385                 390                 395                 400 
Arg Leu Leu Ala Ser Phe Phe Asp Arg Asn Thr Leu Ala Asn Ser Cys
                405                 410                 415     
Gly Thr Gly Ile Arg Ser Ser Thr Asn Asp Pro Arg Arg Lys Pro Leu
            420                 425                 430         
Asp Ser Arg Val Leu His Ala Val Lys Tyr Tyr Cys Gln Asn Phe Ala
        435                 440                 445             
Pro Asn Phe Lys Glu Ser Glu Met Asn Ala Ile Ala Ala Asp Met Cys
    450                 455                 460                 
Thr Asn Ala Arg Arg Val Val Arg Lys Ser Trp Met Pro Lys Val Lys
465                 470                 475                 480 
Val Leu Lys Ala Glu Asp Asp Ala Tyr Thr Thr Phe Ile Ser Glu Thr
                485                 490                 495     
Gly Lys Ile Glu Pro Asp Met Met Gly Val Glu His Gly Phe Glu Thr
            500                 505                 510         
Ala Ser His Glu Gly Glu Ala Gly Pro Ser Ala Glu Ala Leu Gln
        515                 520                 525         


<210> 2356
<211> 351
<212> PRT
<213> Homo sapiens

<400> 2356
Met Glu Pro Ala Pro Gly Leu Val Glu Gln Pro Lys Cys Leu Glu Ala
 1               5                  10                  15      
Gly Ser Pro Glu Pro Glu Pro Ala Pro Trp Gln Ala Leu Pro Val Leu
            20                  25                  30          
Ser Glu Lys Gln Ser Gly Asp Val Glu Leu Val Leu Ala Tyr Ala Ala
        35                  40                  45              
Pro Val Leu Asp Lys Arg Gln Thr Ser Arg Leu Leu Lys Glu Val Ser
    50                  55                  60                  
Ala Leu His Pro Leu Pro Ala Gln Pro His Leu Lys Arg Val Arg Pro
65                  70                  75                  80  
Ser Arg Asp Ala Gly Ser Pro His Ala Leu Glu Met Leu Leu Cys Leu
                85                  90                  95      
Ala Gly Pro Ala Ser Gly Pro Arg Ser Leu Ala Glu Leu Leu Pro Arg
            100                 105                 110         
Pro Ala Val Asp Pro Arg Gly Leu Gly Gln Pro Phe Leu Val Pro Val
        115                 120                 125             
Pro Ala Arg Pro Pro Leu Thr Arg Gly Gln Phe Glu Glu Ala Arg Ala
    130                 135                 140                 
His Trp Pro Thr Ser Phe His Glu Asp Lys Gln Val Thr Ser Ala Leu
145                 150                 155                 160 
Ala Gly Arg Leu Phe Ser Thr Gln Glu Arg Ala Ala Met Gln Ser His
                165                 170                 175     
Met Glu Arg Ala Val Trp Ala Ala Arg Arg Ala Ala Ala Arg Gly Leu
            180                 185                 190         
Arg Ala Val Gly Ala Val Val Val Asp Pro Ala Ser Asp Arg Val Leu
        195                 200                 205             
Ala Thr Gly His Asp Cys Ser Cys Ala Asp Asn Pro Leu Leu His Ala
    210                 215                 220                 
Val Met Val Cys Val Asp Leu Val Ala Arg Gly Gln Gly Arg Gly Thr
225                 230                 235                 240 
Tyr Asp Phe Arg Pro Phe Pro Ala Cys Ser Phe Ala Pro Ala Ala Ala
                245                 250                 255     
Pro Gln Ala Val Arg Ala Gly Ala Val Arg Lys Leu Asp Ala Asp Glu
            260                 265                 270         
Asp Gly Leu Pro Tyr Leu Cys Thr Gly Tyr Asp Leu Tyr Val Thr Arg
        275                 280                 285             
Glu Pro Cys Ala Met Cys Ala Met Ala Leu Val His Ala Arg Ile Leu
    290                 295                 300                 
Arg Val Phe Tyr Gly Ala Pro Ser Pro Asp Gly Ala Leu Gly Thr Arg
305                 310                 315                 320 
Phe Arg Ile His Ala Arg Pro Asp Leu Asn His Arg Phe Gln Val Phe
                325                 330                 335     
Arg Gly Val Leu Glu Glu Gln Cys Arg Trp Leu Asp Pro Asp Thr
            340                 345                 350     


<210> 2357
<211> 1441
<212> PRT
<213> Homo sapiens

<400> 2357
Met Arg Ala Gly Val Gln Thr Gly Asp Arg Ile Ile Lys Val Asn Gly
 1               5                  10                  15      
Thr Leu Val Thr His Ser Asn His Leu Glu Val Val Lys Leu Ile Lys
            20                  25                  30          
Ser Gly Ser Tyr Val Ala Leu Thr Val Gln Gly Arg Pro Pro Gly Ser
        35                  40                  45              
Pro Gln Ile Pro Leu Ala Asp Ser Glu Val Glu Pro Ser Val Ile Gly
    50                  55                  60                  
His Met Ser Pro Ile Met Thr Ser Pro His Ser Pro Gly Ala Ser Gly
65                  70                  75                  80  
Asn Met Glu Arg Ile Thr Ser Pro Val Leu Met Gly Glu Glu Asn Asn
                85                  90                  95      
Val Val His Asn Gln Lys Val Glu Ile Leu Arg Lys Met Leu Gln Lys
            100                 105                 110         
Glu Gln Glu Arg Leu Gln Leu Leu Gln Glu Asp Tyr Asn Arg Thr Pro
        115                 120                 125             
Ala Gln Arg Leu Leu Lys Glu Ile Gln Glu Ala Lys Lys His Ile Pro
    130                 135                 140                 
Gln Leu Gln Glu Gln Leu Ser Lys Ala Thr Gly Ser Ala Gln Asp Gly
145                 150                 155                 160 
Ala Val Val Thr Pro Ser Arg Pro Leu Gly Asp Thr Leu Thr Val Ser
                165                 170                 175     
Glu Ala Glu Thr Asp Pro Gly Asp Val Leu Gly Arg Thr Asp Cys Ser
            180                 185                 190         
Ser Gly Asp Ala Ser Arg Pro Ser Ser Asp Asn Ala Asp Ser Pro Lys
        195                 200                 205             
Ser Gly Pro Lys Glu Arg Ile Tyr Leu Glu Glu Asn Pro Glu Lys Ser
    210                 215                 220                 
Glu Thr Ile Gln Asp Thr Asp Thr Gln Ser Leu Val Gly Ser Pro Ser
225                 230                 235                 240 
Thr Arg Ile Ala Pro His Ile Ile Gly Ala Glu Asp Asp Asp Phe Gly
                245                 250                 255     
Thr Glu His Glu Gln Ile Asn Gly Gln Cys Ser Cys Phe Gln Ser Ile
            260                 265                 270         
Glu Leu Leu Lys Ser Arg Pro Ala His Leu Ala Val Phe Leu His His
        275                 280                 285             
Val Val Ser Gln Phe Asp Pro Ala Thr Leu Leu Cys Tyr Leu Tyr Ser
    290                 295                 300                 
Asp Leu Tyr Lys His Thr Asn Ser Lys Glu Thr Arg Arg Ile Phe Leu
305                 310                 315                 320 
Glu Phe His Gln Phe Phe Leu Asp Arg Ser Ala His Leu Lys Val Ser
                325                 330                 335     
Val Pro Asp Glu Met Ser Ala Asp Leu Glu Lys Arg Arg Pro Glu Leu
            340                 345                 350         
Ile Pro Glu Asp Leu His Arg His Tyr Ile Gln Thr Met Gln Glu Arg
        355                 360                 365             
Val His Pro Glu Val Gln Arg His Leu Glu Asp Phe Arg Gln Lys Arg
    370                 375                 380                 
Ser Met Gly Leu Thr Leu Ala Glu Ser Glu Leu Thr Lys Leu Asp Ala
385                 390                 395                 400 
Glu Arg Asp Lys Asp Arg Leu Thr Leu Glu Lys Glu Arg Thr Cys Ala
                405                 410                 415     
Glu Gln Ile Val Ala Lys Ile Glu Glu Val Leu Met Thr Ala Gln Ala
            420                 425                 430         
Val Glu Glu Asp Lys Ser Ser Thr Met Gln Tyr Val Ile Leu Met Tyr
        435                 440                 445             
Met Lys His Leu Gly Val Lys Val Lys Glu Pro Arg Asn Leu Glu His
    450                 455                 460                 
Lys Arg Gly Arg Ile Gly Phe Leu Pro Lys Ile Lys Gln Ser Met Lys
465                 470                 475                 480 
Lys Asp Lys Glu Gly Glu Glu Lys Gly Lys Arg Arg Gly Phe Pro Ser
                485                 490                 495     
Ile Leu Gly Pro Pro Arg Arg Pro Ser Arg His Asp Asn Ser Ala Ile
            500                 505                 510         
Gly Arg Ala Met Glu Leu Gln Lys Ala Arg His Pro Lys His Leu Ser
        515                 520                 525             
Thr Pro Ser Ser Val Ser Pro Glu Pro Gln Asp Ser Ala Lys Leu Arg
    530                 535                 540                 
Gln Ser Gly Leu Ala Asn Glu Gly Thr Asp Ala Gly Tyr Leu Pro Ala
545                 550                 555                 560 
Asn Ser Met Ser Ser Val Ala Ser Gly Ala Ser Phe Ser Gln Glu Gly
                565                 570                 575     
Gly Lys Glu Asn Asp Thr Gly Ser Lys Gln Val Gly Glu Thr Ser Ala
            580                 585                 590         
Pro Gly Asp Thr Leu Asp Gly Thr Pro Arg Thr Leu Asn Thr Val Phe
        595                 600                 605             
Asp Phe Pro Pro Pro Pro Leu Asp Gln Val Gln Glu Glu Glu Cys Glu
    610                 615                 620                 
Val Glu Arg Val Thr Glu His Gly Thr Pro Lys Pro Phe Arg Lys Phe
625                 630                 635                 640 
Asp Ser Val Ala Phe Gly Glu Ser Gln Ser Glu Asp Glu Gln Phe Glu
                645                 650                 655     
Asn Asp Leu Glu Thr Asp Pro Pro Asn Trp Gln Gln Leu Val Ser Arg
            660                 665                 670         
Glu Val Leu Leu Gly Leu Lys Pro Cys Glu Ile Lys Arg Gln Glu Val
        675                 680                 685             
Ile Asn Glu Leu Phe Tyr Thr Glu Arg Ala His Val Arg Thr Leu Lys
    690                 695                 700                 
Val Leu Asp Gln Val Phe Tyr Gln Arg Val Ser Arg Glu Gly Ile Leu
705                 710                 715                 720 
Ser Pro Ser Glu Leu Arg Lys Ile Phe Ser Asn Leu Glu Asp Ile Leu
                725                 730                 735     
Gln Leu His Ile Gly Leu Asn Glu Gln Met Lys Ala Val Arg Lys Arg
            740                 745                 750         
Asn Glu Thr Ser Val Ile Asp Gln Ile Gly Glu Asp Leu Leu Thr Trp
        755                 760                 765             
Phe Ser Gly Pro Gly Glu Glu Lys Leu Lys His Ala Ala Ala Thr Phe
    770                 775                 780                 
Cys Ser Asn Gln Pro Phe Ala Leu Glu Met Ile Lys Ser Arg Gln Lys
785                 790                 795                 800 
Lys Asp Ser Arg Phe Gln Thr Phe Val Gln Asp Ala Glu Ser Asn Pro
                805                 810                 815     
Leu Cys Arg Arg Leu Gln Leu Lys Asp Ile Ile Pro Thr Gln Met Gln
            820                 825                 830         
Arg Leu Thr Lys Tyr Pro Leu Leu Leu Asp Asn Ile Ala Lys Tyr Thr
        835                 840                 845             
Glu Trp Pro Thr Glu Arg Glu Lys Val Lys Lys Ala Ala Asp His Cys
    850                 855                 860                 
Arg Gln Ile Leu Asn Tyr Val Asn Gln Ala Val Lys Glu Ala Glu Asn
865                 870                 875                 880 
Lys Gln Arg Leu Glu Asp Tyr Gln Arg Arg Leu Asp Thr Ser Ser Leu
                885                 890                 895     
Lys Leu Ser Glu Tyr Pro Asn Val Glu Glu Leu Arg Asn Leu Asp Leu
            900                 905                 910         
Thr Lys Arg Lys Met Ile His Glu Gly Pro Leu Val Trp Lys Val Asn
        915                 920                 925             
Arg Asp Lys Thr Ile Asp Leu Tyr Thr Leu Leu Leu Glu Asp Ile Leu
    930                 935                 940                 
Val Leu Leu Gln Lys Gln Asp Asp Arg Leu Val Leu Arg Cys His Ser
945                 950                 955                 960 
Lys Ile Leu Ala Ser Thr Ala Asp Ser Lys His Thr Phe Ser Pro Val
                965                 970                 975     
Ile Lys Leu Ser Thr Val Leu Val Arg Gln Val Ala Thr Asp Asn Lys
            980                 985                 990         
Ala Leu Phe Val Ile Ser Met Ser Asp Asn Gly Ala Gln Ile Tyr Glu
        995                 1000                1005            
Leu Val Ala Gln Thr Val Ser Glu Lys Thr Val Trp Gln Asp Leu Ile
    1010                1015                1020                
Cys Arg Met Ala Ala Ser Val Lys Glu Gln Ser Thr Lys Pro Ile Pro
1025                1030                1035                1040
Leu Pro Gln Ser Thr Pro Gly Glu Gly Asp Asn Asp Glu Glu Asp Pro
                1045                1050                1055    
Ser Lys Leu Lys Glu Glu Gln His Gly Ile Ser Val Thr Gly Leu Gln
            1060                1065                1070        
Ser Pro Asp Arg Asp Leu Gly Leu Glu Ser Thr Leu Ile Ser Ser Lys
        1075                1080                1085            
Pro Gln Ser His Ser Leu Ser Thr Ser Gly Lys Ser Glu Val Arg Asp
    1090                1095                1100                
Leu Phe Val Ala Glu Arg Gln Phe Ala Lys Glu Gln His Thr Asp Gly
1105                1110                1115                1120
Thr Leu Lys Glu Val Gly Glu Asp Tyr Gln Ile Ala Ile Pro Asp Ser
                1125                1130                1135    
His Leu Pro Val Ser Glu Glu Arg Trp Ala Leu Asp Ala Leu Arg Asn
            1140                1145                1150        
Leu Gly Leu Leu Lys Gln Leu Leu Val Gln Gln Leu Gly Leu Thr Glu
        1155                1160                1165            
Lys Ser Val Gln Glu Asp Trp Gln His Phe Pro Arg Tyr Arg Thr Ala
    1170                1175                1180                
Ser Gln Gly Pro Gln Thr Asp Ser Val Ile Gln Asn Ser Glu Asn Ile
1185                1190                1195                1200
Lys Ala Tyr His Ser Gly Glu Gly His Met Pro Phe Arg Thr Gly Thr
                1205                1210                1215    
Gly Asp Ile Ala Thr Cys Tyr Ser Pro Arg Thr Ser Thr Glu Ser Phe
            1220                1225                1230        
Ala Pro Arg Asp Ser Val Gly Leu Ala Pro Gln Asp Ser Gln Ala Ser
        1235                1240                1245            
Asn Ile Leu Val Met Asp His Met Ile Met Thr Pro Glu Met Pro Thr
    1250                1255                1260                
Met Glu Pro Glu Gly Gly Leu Asp Asp Ser Gly Glu His Phe Phe Asp
1265                1270                1275                1280
Ala Arg Glu Ala His Ser Asp Glu Asn Pro Ser Glu Gly Asp Gly Ala
                1285                1290                1295    
Val Asn Lys Glu Glu Lys Asp Val Asn Leu Arg Ile Ser Gly Asn Tyr
            1300                1305                1310        
Leu Ile Leu Asp Gly Tyr Asp Pro Val Gln Glu Ser Ser Thr Asp Glu
        1315                1320                1325            
Glu Val Ala Ser Ser Leu Thr Leu Gln Pro Met Thr Gly Ile Pro Ala
    1330                1335                1340                
Val Glu Ser Thr His Gln Gln Gln His Ser Pro Gln Asn Thr His Ser
1345                1350                1355                1360
Asp Gly Ala Ile Ser Pro Phe Thr Pro Glu Phe Leu Val Gln Gln Arg
                1365                1370                1375    
Trp Gly Ala Met Glu Tyr Ser Cys Phe Glu Ile Gln Ser Pro Ser Ser
            1380                1385                1390        
Cys Ala Asp Ser Gln Ser Gln Ile Met Glu Tyr Ile His Lys Ile Glu
        1395                1400                1405            
Ala Asp Leu Glu His Leu Lys Lys Val Glu Glu Ser Tyr Thr Ile Leu
    1410                1415                1420                
Cys Gln Arg Leu Ala Gly Ser Ala Leu Thr Asp Lys His Ser Asp Lys
1425                1430                1435                1440
Ser
    


<210> 2358
<211> 210
<212> PRT
<213> Homo sapiens

<400> 2358
Met Arg Cys Leu Thr Thr Pro Met Leu Leu Arg Ala Leu Ala Gln Ala
 1               5                  10                  15      
Ala Arg Ala Gly Pro Pro Gly Gly Arg Ser Leu His Ser Ser Ala Val
            20                  25                  30          
Ala Ala Thr Tyr Lys Tyr Val Asn Met Gln Asp Pro Glu Met Asp Met
        35                  40                  45              
Lys Ser Val Thr Asp Arg Ala Ala Arg Thr Leu Leu Trp Thr Glu Leu
    50                  55                  60                  
Phe Arg Gly Leu Gly Met Thr Leu Ser Tyr Leu Phe Arg Glu Pro Ala
65                  70                  75                  80  
Thr Ile Asn Tyr Pro Phe Glu Lys Gly Pro Leu Ser Pro Arg Phe Arg
                85                  90                  95      
Gly Glu His Ala Leu Arg Arg Tyr Pro Ser Gly Glu Glu Arg Cys Ile
            100                 105                 110         
Ala Cys Lys Leu Cys Glu Ala Ile Cys Pro Ala Gln Ala Ile Thr Ile
        115                 120                 125             
Glu Ala Glu Pro Arg Ala Asp Gly Ser Arg Arg Thr Thr Arg Tyr Asp
    130                 135                 140                 
Ile Asp Met Thr Lys Cys Ile Tyr Cys Gly Phe Cys Gln Glu Ala Cys
145                 150                 155                 160 
Pro Val Asp Ala Ile Val Glu Gly Pro Asn Phe Glu Phe Ser Thr Glu
                165                 170                 175     
Thr His Glu Glu Leu Leu Tyr Thr Lys Glu Lys Leu Leu Asn Asn Gly
            180                 185                 190         
Asp Lys Trp Glu Ala Glu Ile Ala Ala Asn Ile Gln Ala Asp Tyr Leu
        195                 200                 205             
Tyr Arg
    210 


<210> 2359
<211> 583
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 530, 531, 532, 533, 534, 535, 536, 537, 538, 539, 540, 541,
542, 543, 544, 545, 546, 547, 548, 549, 550, 551
<223> Xaa = Any Amino Acid

<400> 2359
Met Gly Ala Val Tyr Gln Ala Ala Ala Leu Ser Lys Ala Phe Lys Val
 1               5                  10                  15      
Lys Pro Phe Val Val Arg Asp Ala Val Val Tyr Pro Ile Leu Val Glu
            20                  25                  30          
Phe Thr Arg Glu Val Glu Glu Glu Pro Gly Ile His Ser Leu Lys His
        35                  40                  45              
Asn Lys Arg Val Leu Phe Ser Arg Met Gly Pro Tyr Pro Gln Arg Lys
    50                  55                  60                  
Val Ile Thr Phe Asn Arg Tyr Ser His Asp Phe Asn Phe His Ile Asn
65                  70                  75                  80  
Tyr Gly Asp Leu Gly Phe Leu Gly Pro Glu Asp Leu Arg Val Phe Gly
                85                  90                  95      
Ser Gln Asn Leu Thr Thr Val Lys Leu Lys Gly Val Gly Asp Ser Phe
            100                 105                 110         
Lys Lys Tyr Pro Asp Tyr Glu Ser Lys Gly Ile Lys Ala His Phe Asn
        115                 120                 125             
Leu Asp Glu Ser Gly Val Leu Ser Leu Asp Arg Val Glu Ser Val Phe
    130                 135                 140                 
Glu Thr Leu Val Glu Asp Ser Ala Glu Glu Glu Ser Thr Leu Thr Lys
145                 150                 155                 160 
Leu Gly Asn Thr Ile Ser Ser Leu Phe Gly Gly Gly Thr Thr Pro Asp
                165                 170                 175     
Ala Lys Glu Asn Gly Thr Asp Thr Val Gln Glu Glu Glu Glu Ser Pro
            180                 185                 190         
Ala Glu Gly Ser Lys Asp Glu Pro Gly Glu Gln Val Glu Leu Lys Glu
        195                 200                 205             
Glu Ala Glu Ala Pro Val Glu Asp Gly Ser Gln Pro Pro Pro Pro Glu
    210                 215                 220                 
Pro Lys Gly Asp Ala Thr Pro Glu Gly Glu Lys Ala Thr Glu Lys Glu
225                 230                 235                 240 
Asn Gly Asp Lys Ser Glu Ala Gln Lys Pro Ser Glu Lys Ala Glu Ala
                245                 250                 255     
Gly Pro Glu Gly Val Ala Pro Ala Pro Glu Gly Glu Lys Lys Gln Lys
            260                 265                 270         
Pro Ala Arg Lys Arg Arg Met Val Glu Glu Ile Gly Val Glu Leu Val
        275                 280                 285             
Val Leu Asp Leu Pro Asp Leu Pro Glu Asp Lys Leu Ala Gln Ser Val
    290                 295                 300                 
Gln Lys Leu Gln Asp Leu Thr Leu Arg Asp Leu Glu Lys Gln Glu Arg
305                 310                 315                 320 
Glu Lys Ala Ala Asn Ser Leu Glu Ala Phe Ile Phe Glu Thr Gln Asp
                325                 330                 335     
Lys Leu Tyr Gln Pro Glu Tyr Gln Glu Val Ser Thr Glu Glu Gln Arg
            340                 345                 350         
Glu Glu Ile Ser Gly Lys Leu Ser Ala Ala Ser Thr Trp Leu Glu Asp
        355                 360                 365             
Glu Gly Val Gly Ala Thr Thr Val Met Leu Lys Glu Lys Leu Ala Glu
    370                 375                 380                 
Leu Arg Lys Leu Cys Gln Gly Leu Phe Phe Arg Val Glu Glu Arg Lys
385                 390                 395                 400 
Lys Trp Pro Glu Arg Leu Ser Ala Leu Asp Asn Leu Leu Asn His Ser
                405                 410                 415     
Ser Met Phe Leu Lys Gly Ala Arg Leu Ile Pro Glu Met Asp Gln Ile
            420                 425                 430         
Phe Thr Glu Val Glu Met Thr Thr Leu Glu Lys Val Ile Asn Glu Thr
        435                 440                 445             
Trp Ala Trp Lys Asn Ala Thr Leu Ala Glu Gln Ala Lys Leu Pro Ala
    450                 455                 460                 
Thr Glu Lys Pro Val Leu Leu Ser Lys Asp Ile Glu Ala Lys Met Met
465                 470                 475                 480 
Ala Leu Asp Arg Glu Val Gln Tyr Leu Leu Asn Lys Ala Lys Phe Thr
                485                 490                 495     
Lys Pro Arg Pro Arg Pro Lys Thr Arg Met Gly Pro Gly Gln Ser His
            500                 505                 510         
Pro Ser Met Pro Val Pro Val Thr Arg Gly Lys Lys Val Ile Pro Pro
        515                 520                 525             
Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    530                 535                 540                 
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asp Thr Glu Pro Leu Glu Leu Gly Gly
545                 550                 555                 560 
Pro Gly Ala Glu Pro Glu Gln Lys Glu Gln Ser Thr Gly Gln Lys Arg
                565                 570                 575     
Pro Leu Lys Asn Asp Glu Leu
            580             


<210> 2360
<211> 665
<212> PRT
<213> Homo sapiens

<400> 2360
Met Ser His Phe Glu Pro Asn Glu Tyr Ile His Tyr Asp Leu Leu Glu
 1               5                  10                  15      
Lys Asn Ile Asn Ile Val Arg Lys Arg Leu Asn Arg Pro Leu Thr Leu
            20                  25                  30          
Ser Glu Lys Ile Val Tyr Gly His Leu Asp Asp Pro Ala Ser Gln Glu
        35                  40                  45              
Ile Glu Arg Gly Lys Ser Tyr Leu Arg Leu Arg Pro Asp Arg Val Ala
    50                  55                  60                  
Met Gln Asp Ala Thr Ala Gln Met Ala Met Leu Gln Phe Ile Ser Ser
65                  70                  75                  80  
Gly Leu Ser Lys Val Ala Val Pro Ser Thr Ile His Cys Asp His Leu
                85                  90                  95      
Ile Glu Ala Gln Val Gly Gly Glu Lys Asp Leu Arg Arg Ala Lys Asp
            100                 105                 110         
Ile Asn Gln Glu Val Tyr Asn Phe Leu Ala Thr Ala Gly Ala Lys Tyr
        115                 120                 125             
Gly Val Gly Phe Trp Lys Pro Gly Ser Gly Ile Ile His Gln Ile Ile
    130                 135                 140                 
Leu Glu Asn Tyr Ala Tyr Pro Gly Val Leu Leu Ile Gly Thr Asp Ser
145                 150                 155                 160 
His Thr Pro Asn Gly Gly Gly Leu Gly Gly Ile Cys Ile Gly Val Gly
                165                 170                 175     
Gly Ala Asp Ala Val Asp Val Met Ala Gly Ile Pro Trp Glu Leu Lys
            180                 185                 190         
Cys Pro Lys Val Ile Gly Val Lys Leu Thr Gly Ser Leu Ser Gly Trp
        195                 200                 205             
Ser Ser Pro Lys Asp Val Ile Leu Lys Val Ala Gly Ile Leu Thr Val
    210                 215                 220                 
Lys Gly Gly Thr Gly Ala Ile Val Glu Tyr His Gly Pro Gly Val Asp
225                 230                 235                 240 
Ser Ile Ser Cys Thr Gly Met Ala Thr Ile Cys Asn Met Gly Ala Glu
                245                 250                 255     
Ile Gly Ala Thr Thr Ser Val Phe Pro Tyr Asn His Arg Met Lys Lys
            260                 265                 270         
Tyr Leu Ser Lys Thr Gly Arg Glu Asp Ile Ala Asn Leu Ala Asp Glu
        275                 280                 285             
Phe Lys Asp His Leu Val Pro Asp Pro Gly Cys His Tyr Asp Gln Leu
    290                 295                 300                 
Ile Glu Ile Asn Leu Ser Glu Leu Lys Pro His Ile Asn Gly Pro Phe
305                 310                 315                 320 
Thr Pro Asp Leu Ala His Pro Val Ala Glu Val Gly Lys Val Ala Glu
                325                 330                 335     
Lys Glu Gly Trp Pro Leu Asp Ile Arg Val Gly Leu Ile Gly Ser Cys
            340                 345                 350         
Thr Asn Ser Ser Tyr Glu Asp Met Gly Arg Ser Ala Ala Val Ala Lys
        355                 360                 365             
Gln Ala Leu Ala His Gly Leu Lys Cys Lys Ser Gln Phe Thr Ile Thr
    370                 375                 380                 
Pro Gly Ser Glu Gln Ile Arg Ala Thr Ile Glu Arg Asp Gly Tyr Ala
385                 390                 395                 400 
Gln Ile Leu Arg Asp Leu Gly Gly Ile Val Leu Ala Asn Ala Cys Gly
                405                 410                 415     
Pro Cys Ile Gly Gln Trp Asp Arg Lys Asp Ile Lys Lys Gly Glu Lys
            420                 425                 430         
Asn Thr Ile Val Thr Ser Tyr Asn Arg Asn Phe Thr Gly Arg Asn Asp
        435                 440                 445             
Ala Asn Pro Glu Thr His Ala Phe Val Thr Ser Pro Glu Ile Val Thr
    450                 455                 460                 
Ala Leu Ala Ile Ala Gly Thr Leu Lys Phe Asn Pro Glu Thr Asp Tyr
465                 470                 475                 480 
Leu Thr Gly Thr Asp Gly Lys Lys Phe Arg Leu Glu Ala Pro Asp Ala
                485                 490                 495     
Asp Glu Leu Pro Lys Gly Glu Phe Asp Pro Gly Gln Asp Thr Tyr Gln
            500                 505                 510         
His Pro Pro Lys Asp Ser Ser Gly Gln His Val Asp Val Ser Pro Thr
        515                 520                 525             
Ser Gln Arg Leu Gln Leu Leu Glu Pro Phe Asp Lys Trp Asp Gly Lys
    530                 535                 540                 
Asp Leu Glu Asp Leu Gln Ile Leu Ile Lys Val Lys Gly Lys Cys Thr
545                 550                 555                 560 
Thr Asp His Ile Ser Ala Ala Gly Pro Trp Leu Lys Phe Arg Gly His
                565                 570                 575     
Leu Asp Asn Ile Ser Asn Asn Leu Leu Ile Gly Ala Ile Asn Ile Glu
            580                 585                 590         
Asn Gly Lys Ala Asn Ser Val Arg Asn Ala Val Thr Gln Glu Phe Gly
        595                 600                 605             
Pro Val Pro Asp Thr Ala Arg Tyr Tyr Lys Lys His Gly Ile Arg Trp
    610                 615                 620                 
Val Val Ile Gly Asp Glu Asn Tyr Gly Glu Gly Ser Ser Arg Glu His
625                 630                 635                 640 
Ala Ala Leu Glu Pro Arg His Leu Gly Gly Arg Ala Ile Ile Thr Lys
                645                 650                 655     
Ser Phe Ala Arg Ile His Gly Pro Thr
            660                 665 


<210> 2361
<211> 291
<212> PRT
<213> Homo sapiens

<400> 2361
Met Val Leu Phe Pro Val Trp Phe Leu Tyr Ser Leu Leu Met Lys Leu
 1               5                  10                  15      
Phe Gln Arg Ser Thr Pro Ala Ile Thr Leu Glu Ser Pro Asp Ile Lys
            20                  25                  30          
Tyr Pro Leu Arg Leu Ile Asp Arg Glu Ile Ile Ser His Asp Thr Arg
        35                  40                  45              
Arg Phe Arg Phe Ala Leu Pro Ser Pro Gln His Ile Leu Gly Leu Pro
    50                  55                  60                  
Val Gly Gln His Ile Tyr Leu Ser Ala Arg Ile Asp Gly Asn Leu Val
65                  70                  75                  80  
Val Arg Pro Tyr Thr Pro Ile Ser Ser Asp Asp Asp Lys Gly Phe Val
                85                  90                  95      
Asp Leu Val Ile Lys Val Tyr Phe Lys Asp Thr His Pro Lys Phe Pro
            100                 105                 110         
Ala Gly Gly Lys Met Ser Gln Tyr Leu Glu Ser Met Gln Ile Gly Asp
        115                 120                 125             
Thr Ile Glu Phe Arg Gly Pro Ser Gly Leu Leu Val Tyr Gln Gly Lys
    130                 135                 140                 
Gly Lys Phe Ala Ile Arg Pro Asp Lys Lys Ser Asn Pro Ile Ile Arg
145                 150                 155                 160 
Thr Val Lys Ser Val Gly Met Ile Ala Gly Gly Thr Gly Ile Thr Pro
                165                 170                 175     
Met Leu Gln Val Ile Arg Ala Ile Met Lys Asp Pro Asp Asp His Thr
            180                 185                 190         
Val Cys His Leu Leu Phe Ala Asn Gln Thr Glu Lys Asp Ile Leu Leu
        195                 200                 205             
Arg Pro Glu Leu Glu Glu Leu Arg Asn Lys His Ser Ala Arg Phe Lys
    210                 215                 220                 
Leu Trp Tyr Thr Leu Asp Arg Ala Pro Glu Ala Trp Asp Tyr Gly Gln
225                 230                 235                 240 
Gly Phe Val Asn Glu Glu Met Ile Arg Asp His Leu Pro Pro Pro Glu
                245                 250                 255     
Glu Glu Pro Leu Val Leu Met Cys Gly Pro Pro Pro Met Ile Gln Tyr
            260                 265                 270         
Ala Cys Leu Pro Asn Leu Asp His Val Gly His Pro Thr Glu Arg Cys
        275                 280                 285             
Phe Val Phe
    290     


<210> 2362
<211> 336
<212> PRT
<213> Homo sapiens

<400> 2362
Met Phe Gly Ser Val Ala Leu Gly Pro Val Cys Pro Thr Val Cys Pro
 1               5                  10                  15      
Pro Gly Gly Ile His Gln Val Thr Val Asn Glu Ser Leu Leu Ala Pro
            20                  25                  30          
Leu Asn Val Glu Leu Asp Pro Glu Ile Gln Lys Val Arg Ala Gln Glu
        35                  40                  45              
Arg Glu Gln Ile Lys Ala Leu Asn Asn Lys Phe Ala Ser Phe Ile Asp
    50                  55                  60                  
Lys Val Arg Phe Leu Glu Gln Gln Asn Gln Val Leu Glu Thr Lys Trp
65                  70                  75                  80  
Glu Leu Leu Gln Gln Leu Asp Leu Asn Asn Cys Lys Asn Asn Leu Glu
                85                  90                  95      
Pro Ile Leu Glu Gly Tyr Ile Ser Asn Leu Arg Lys Gln Leu Glu Thr
            100                 105                 110         
Leu Ser Gly Asp Arg Val Arg Leu Asp Ser Glu Leu Arg Asn Val Arg
        115                 120                 125             
Asp Val Val Glu Asp Tyr Lys Lys Arg Tyr Glu Glu Glu Ile Asn Lys
    130                 135                 140                 
Arg Thr Ala Ala Glu Asn Glu Phe Val Leu Leu Lys Lys Asp Val Asp
145                 150                 155                 160 
Ala Ala Tyr Ala Asn Lys Val Glu Leu Gln Ala Lys Val Glu Ser Met
                165                 170                 175     
Asp Gln Glu Ile Lys Phe Phe Arg Cys Leu Phe Glu Ala Glu Ile Thr
            180                 185                 190         
Gln Ile Gln Ser His Ile Ser Asp Met Ser Val Ile Leu Ser Met Asp
        195                 200                 205             
Asn Asn Arg Asn Leu Asp Leu Asp Ser Ile Ile Asp Glu Val Arg Thr
    210                 215                 220                 
Gln Tyr Glu Glu Ile Ala Leu Lys Ser Lys Ala Glu Ala Glu Ala Leu
225                 230                 235                 240 
Tyr Gln Thr Lys Phe Gln Glu Leu Gln Leu Ala Ala Gly Arg His Gly
                245                 250                 255     
Asp Asp Leu Lys Asn Thr Lys Leu Gly Glu Ile Pro Pro Cys Thr His
            260                 265                 270         
Pro Ile Asn Ser Leu Ala Val Val Pro Gln Leu His His Gln Pro Arg
        275                 280                 285             
Ser Trp Leu Pro Ala Phe Leu Leu Cys Pro Ala Ser Ser Ala Val Ala
    290                 295                 300                 
Asn Tyr Ser Ala Gly Leu Pro Gly Ser Leu Pro Lys Ala Pro His Thr
305                 310                 315                 320 
Leu Gly Pro Ser Ile Val Pro Ala Tyr Ala Arg Ser Trp Leu Cys Val
                325                 330                 335     


<210> 2363
<211> 808
<212> PRT
<213> Homo sapiens

<400> 2363
Met Val Cys Asn His Leu Cys Ser Ser Asp Gly Cys Trp Gly Pro Gly
 1               5                  10                  15      
Pro Asp Gln Cys Leu Ser Cys Arg Arg Phe Ser Arg Gly Arg Ile Cys
            20                  25                  30          
Ile Glu Ser Cys Asn Leu Tyr Asp Gly Glu Phe Arg Glu Phe Glu Asn
        35                  40                  45              
Gly Ser Ile Cys Val Glu Cys Asp Pro Gln Cys Glu Lys Met Glu Asp
    50                  55                  60                  
Gly Leu Leu Thr Cys His Gly Pro Gly Pro Asp Asn Cys Thr Lys Cys
65                  70                  75                  80  
Ser His Phe Lys Asp Gly Pro Asn Cys Val Glu Lys Cys Pro Asp Gly
                85                  90                  95      
Leu Gln Gly Ala Asn Ser Phe Ile Phe Lys Tyr Ala Asp Pro Asp Arg
            100                 105                 110         
Glu Cys His Pro Cys His Pro Asn Cys Thr Gln Gly Cys Asn Gly Pro
        115                 120                 125             
Thr Ser His Asp Cys Ile Tyr Tyr Pro Trp Thr Gly His Ser Thr Leu
    130                 135                 140                 
Pro Gln His Ala Arg Thr Pro Leu Ile Ala Ala Gly Val Ile Gly Gly
145                 150                 155                 160 
Leu Phe Ile Leu Val Ile Val Gly Leu Thr Phe Ala Val Tyr Val Arg
                165                 170                 175     
Arg Lys Ser Ile Lys Lys Lys Arg Ala Leu Arg Arg Phe Leu Glu Thr
            180                 185                 190         
Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Thr Ala Pro Asn Gln Ala
        195                 200                 205             
Gln Leu Arg Ile Leu Lys Glu Thr Glu Leu Lys Arg Val Lys Val Leu
    210                 215                 220                 
Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Ile Trp Val Pro Glu
225                 230                 235                 240 
Gly Glu Thr Val Lys Ile Pro Val Ala Ile Lys Ile Leu Asn Glu Thr
                245                 250                 255     
Thr Gly Pro Lys Ala Asn Val Glu Phe Met Asp Glu Ala Leu Ile Met
            260                 265                 270         
Ala Ser Met Asp His Pro His Leu Val Arg Leu Leu Gly Val Cys Leu
        275                 280                 285             
Ser Pro Thr Ile Gln Leu Val Thr Gln Leu Met Pro His Gly Cys Leu
    290                 295                 300                 
Leu Glu Tyr Val His Glu His Lys Asp Asn Ile Gly Ser Gln Leu Leu
305                 310                 315                 320 
Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Met Tyr Leu Glu Glu
                325                 330                 335     
Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys
            340                 345                 350         
Ser Pro Asn His Val Lys Ile Thr Asp Phe Gly Leu Ala Arg Leu Leu
        355                 360                 365             
Glu Gly Asp Glu Lys Glu Tyr Asn Ala Asp Gly Gly Lys Met Pro Ile
    370                 375                 380                 
Lys Trp Met Ala Leu Glu Cys Ile His Tyr Arg Lys Phe Thr His Gln
385                 390                 395                 400 
Ser Asp Val Trp Ser Tyr Gly Val Thr Ile Trp Glu Leu Met Thr Phe
                405                 410                 415     
Gly Gly Lys Pro Tyr Asp Gly Ile Pro Thr Arg Glu Ile Pro Asp Leu
            420                 425                 430         
Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp
        435                 440                 445             
Val Tyr Met Val Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg
    450                 455                 460                 
Pro Lys Phe Lys Glu Leu Ala Ala Glu Phe Ser Arg Met Ala Arg Asp
465                 470                 475                 480 
Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Asp Arg Met Lys Leu Pro
                485                 490                 495     
Ser Pro Asn Asp Ser Lys Phe Phe Gln Asn Leu Leu Asp Glu Glu Asp
            500                 505                 510         
Leu Glu Asp Met Met Asp Ala Glu Glu Tyr Leu Val Pro Gln Ala Phe
        515                 520                 525             
Asn Ile Pro Pro Pro Ile Tyr Thr Ser Arg Ala Arg Ile Asp Ser Asn
    530                 535                 540                 
Arg Ser Glu Ile Gly His Ser Pro Pro Pro Ala Tyr Thr Pro Met Ser
545                 550                 555                 560 
Gly Asn Gln Phe Val Tyr Arg Asp Gly Gly Phe Ala Ala Glu Gln Gly
                565                 570                 575     
Val Ser Val Pro Tyr Arg Ala Pro Thr Ser Thr Ile Pro Glu Ala Pro
            580                 585                 590         
Val Ala Gln Gly Ala Thr Ala Glu Ile Phe Asp Asp Ser Cys Cys Asn
        595                 600                 605             
Gly Thr Leu Arg Lys Pro Val Ala Pro His Val Gln Glu Asp Ser Ser
    610                 615                 620                 
Thr Gln Arg Tyr Ser Ala Asp Pro Thr Val Phe Ala Pro Glu Arg Ser
625                 630                 635                 640 
Pro Arg Gly Glu Leu Asp Glu Glu Gly Tyr Met Thr Pro Met Arg Asp
                645                 650                 655     
Lys Pro Lys Gln Glu Tyr Leu Asn Pro Val Glu Glu Asn Pro Phe Val
            660                 665                 670         
Ser Arg Arg Lys Asn Gly Asp Leu Gln Ala Leu Asp Asn Pro Glu Tyr
        675                 680                 685             
His Asn Ala Ser Asn Gly Pro Pro Lys Ala Glu Asp Glu Tyr Val Asn
    690                 695                 700                 
Glu Pro Leu Tyr Leu Asn Thr Phe Ala Asn Thr Leu Gly Lys Ala Glu
705                 710                 715                 720 
Tyr Leu Lys Asn Asn Ile Leu Ser Met Pro Glu Lys Ala Lys Lys Ala
                725                 730                 735     
Phe Asp Asn Pro Asp Tyr Trp Asn His Ser Leu Pro Pro Arg Ser Thr
            740                 745                 750         
Leu Gln His Pro Asp Tyr Leu Gln Glu Tyr Ser Thr Lys Tyr Phe Tyr
        755                 760                 765             
Lys Gln Asn Gly Arg Ile Arg Pro Ile Val Ala Glu Asn Pro Glu Tyr
    770                 775                 780                 
Leu Ser Glu Phe Ser Leu Lys Pro Gly Thr Val Leu Pro Pro Pro Pro
785                 790                 795                 800 
Tyr Arg His Arg Asn Thr Val Val
                805             


<210> 2364
<211> 525
<212> PRT
<213> Homo sapiens

<400> 2364
Met Ala Ala Val Val Leu Ala Ala Thr Arg Leu Leu Arg Gly Ser Gly
 1               5                  10                  15      
Ser Trp Gly Cys Ser Arg Leu Arg Phe Gly Pro Pro Ala Tyr Arg Arg
            20                  25                  30          
Phe Ser Ser Gly Gly Ala Tyr Pro Asn Ile Pro Leu Ser Ser Pro Leu
        35                  40                  45              
Pro Gly Val Pro Lys Pro Val Phe Ala Thr Val Asp Gly Gln Glu Lys
    50                  55                  60                  
Phe Glu Thr Lys Val Thr Thr Leu Asp Asn Gly Leu Arg Val Ala Ser
65                  70                  75                  80  
Gln Asn Lys Phe Gly Gln Phe Cys Thr Val Gly Ile Leu Ile Asn Ser
                85                  90                  95      
Gly Ser Arg Tyr Glu Ala Lys Tyr Leu Ser Gly Ile Ala His Phe Leu
            100                 105                 110         
Glu Lys Leu Ala Phe Ser Ser Thr Ala Arg Phe Asp Ser Lys Asp Glu
        115                 120                 125             
Ile Leu Leu Thr Leu Glu Lys His Gly Gly Ile Cys Asp Cys Gln Thr
    130                 135                 140                 
Ser Arg Asp Thr Thr Met Tyr Ala Val Ser Ala Asp Ser Lys Gly Leu
145                 150                 155                 160 
Asp Thr Val Val Ala Leu Leu Ala Asp Val Val Leu Gln Pro Arg Leu
                165                 170                 175     
Thr Asp Glu Glu Val Glu Met Thr Arg Met Ala Val Gln Phe Glu Leu
            180                 185                 190         
Glu Asp Leu Asn Leu Arg Pro Asp Pro Glu Pro Leu Leu Thr Glu Met
        195                 200                 205             
Ile His Glu Ala Ala Tyr Arg Glu Asn Thr Val Gly Leu His Arg Phe
    210                 215                 220                 
Cys Pro Thr Glu Asn Val Ala Lys Ile Asn Arg Glu Val Leu His Ser
225                 230                 235                 240 
Tyr Leu Arg Asn Tyr Tyr Thr Pro Asp Arg Met Val Leu Ala Gly Val
                245                 250                 255     
Gly Val Glu His Glu His Leu Val Asp Cys Ala Arg Lys Tyr Leu Leu
            260                 265                 270         
Gly Val Gln Pro Ala Trp Gly Ser Ala Glu Ala Val Asp Ile Asp Arg
        275                 280                 285             
Ser Val Ala Gln Tyr Thr Gly Gly Ile Ala Lys Leu Glu Arg Asp Met
    290                 295                 300                 
Ser Asn Val Ser Leu Gly Pro Thr Pro Ile Pro Glu Leu Thr His Ile
305                 310                 315                 320 
Met Val Gly Leu Glu Ser Cys Ser Phe Leu Glu Glu Asp Phe Ile Pro
                325                 330                 335     
Phe Ala Val Leu Asn Met Met Met Gly Gly Gly Gly Ser Phe Ser Ala
            340                 345                 350         
Gly Gly Pro Gly Lys Gly Met Phe Ser Arg Leu Tyr Leu Asn Val Leu
        355                 360                 365             
Asn Arg His His Trp Met Tyr Asn Ala Thr Ser Tyr His His Ser Tyr
    370                 375                 380                 
Glu Asp Thr Gly Leu Leu Cys Ile His Ala Ser Ala Asp Pro Arg Gln
385                 390                 395                 400 
Val Arg Glu Met Val Glu Ile Ile Thr Lys Glu Phe Ile Leu Met Gly
                405                 410                 415     
Gly Thr Val Asp Thr Val Glu Leu Glu Arg Ala Lys Thr Gln Leu Thr
            420                 425                 430         
Ser Met Leu Met Met Asn Leu Glu Ser Arg Pro Val Ile Phe Glu Asp
        435                 440                 445             
Val Gly Arg Gln Val Leu Ala Thr Arg Ser Arg Lys Leu Pro His Glu
    450                 455                 460                 
Leu Cys Thr Leu Ile Arg Asn Val Lys Pro Glu Asp Val Lys Arg Val
465                 470                 475                 480 
Ala Ser Lys Met Leu Arg Gly Lys Pro Ala Val Ala Ala Leu Gly Asp
                485                 490                 495     
Leu Thr Asp Leu Pro Thr Tyr Glu His Ile Gln Thr Ala Leu Ser Ser
            500                 505                 510         
Lys Asp Gly Arg Leu Pro Arg Thr Tyr Arg Leu Phe Arg
        515                 520                 525 


<210> 2365
<211> 367
<212> PRT
<213> Homo sapiens

<400> 2365
Met Val Ala Gln Lys Val Lys Pro Asn Leu Gln Thr Phe Asn Thr Ile
 1               5                  10                  15      
Leu Lys Cys Leu Arg Arg Phe His Val Phe Ala Arg Ser Pro Ala Leu
            20                  25                  30          
Gln Val Leu Arg Glu Met Lys Ala Ile Gly Ile Glu Pro Ser Leu Ala
        35                  40                  45              
Thr Tyr His His Ile Ile Arg Leu Phe Asp Gln Pro Gly Asp Pro Leu
    50                  55                  60                  
Lys Arg Ser Ser Phe Ile Ile Tyr Asp Ile Met Asn Glu Leu Met Gly
65                  70                  75                  80  
Lys Arg Phe Ser Pro Lys Asp Pro Asp Asp Asp Lys Phe Phe Gln Ser
                85                  90                  95      
Ala Met Ser Ile Cys Ser Ser Leu Arg Asp Leu Glu Leu Ala Tyr Gln
            100                 105                 110         
Val His Gly Leu Leu Lys Thr Gly Asp Asn Trp Lys Phe Ile Gly Pro
        115                 120                 125             
Asp Gln His Arg Asn Phe Tyr Tyr Ser Lys Phe Phe Asp Leu Ile Cys
    130                 135                 140                 
Leu Met Glu Gln Ile Asp Val Thr Leu Lys Trp Tyr Glu Asp Leu Ile
145                 150                 155                 160 
Pro Ser Ala Tyr Phe Pro His Ser Gln Thr Met Ile His Leu Leu Gln
                165                 170                 175     
Ala Leu Asp Val Ala Asn Arg Leu Glu Val Ile Pro Lys Ile Trp Lys
            180                 185                 190         
Asp Ser Lys Glu Tyr Gly His Thr Phe Arg Ser Asp Leu Arg Glu Glu
        195                 200                 205             
Ile Leu Met Leu Met Ala Arg Asp Lys His Pro Pro Glu Leu Gln Val
    210                 215                 220                 
Ala Phe Ala Asp Cys Ala Ala Asp Ile Lys Ser Ala Tyr Glu Ser Gln
225                 230                 235                 240 
Pro Ile Arg Gln Thr Ala Gln Asp Trp Pro Ala Thr Ser Leu Asn Cys
                245                 250                 255     
Ile Ala Ile Leu Phe Leu Arg Ala Gly Arg Thr Gln Glu Ala Trp Lys
            260                 265                 270         
Met Leu Gly Leu Phe Arg Lys His Asn Lys Ile Pro Arg Ser Glu Leu
        275                 280                 285             
Leu Asn Glu Leu Met Asp Ser Ala Lys Val Ser Asn Ser Pro Ser Gln
    290                 295                 300                 
Ala Ile Glu Val Val Glu Leu Ala Ser Ala Phe Ser Leu Pro Ile Cys
305                 310                 315                 320 
Glu Gly Leu Thr Gln Arg Val Met Ser Asp Phe Ala Ile Asn Gln Glu
                325                 330                 335     
Gln Lys Glu Ala Leu Ser Asn Leu Thr Ala Leu Thr Ser Asp Ser Asp
            340                 345                 350         
Thr Asp Ser Ser Ser Asp Ser Asp Ser Asp Thr Ser Glu Gly Lys
        355                 360                 365         


<210> 2366
<211> 1066
<212> PRT
<213> Homo sapiens

<400> 2366
Met Thr Ser Tyr Arg Glu Arg Ser Ala Asp Leu Ala Arg Phe Tyr Thr
 1               5                  10                  15      
Val Thr Glu Pro Gln Arg His Pro Arg Gly Tyr Thr Val Tyr Lys Val
            20                  25                  30          
Thr Ala Gly Val Val Ser Arg Arg Asn Pro Glu Asp Val Gln Glu Ile
        35                  40                  45              
Ile Val Trp Lys Arg Tyr Ser Asp Phe Lys Lys Leu His Lys Glu Leu
    50                  55                  60                  
Trp Gln Ile His Lys Asn Leu Phe Arg His Ser Glu Leu Phe Pro Pro
65                  70                  75                  80  
Phe Ala Lys Gly Ile Val Phe Gly Arg Phe Asp Glu Thr Val Ile Glu
                85                  90                  95      
Glu Arg Arg Gln Cys Ala Glu Asp Leu Leu Gln Phe Ser Ala Asn Ile
            100                 105                 110         
Pro Ala Leu Tyr Asn Ser Lys Gln Leu Glu Asp Phe Phe Lys Gly Gly
        115                 120                 125             
Ile Ile Asn Asp Ser Ser Glu Leu Ile Gly Pro Ala Glu Ala His Ser
    130                 135                 140                 
Asp Ser Leu Ile Asp Thr Phe Pro Glu Cys Ser Thr Glu Gly Phe Ser
145                 150                 155                 160 
Ser Asp Ser Asp Leu Val Ser Leu Thr Val Asp Val Asp Ser Leu Ala
                165                 170                 175     
Glu Leu Asp Asp Gly Met Ala Ser Asn Gln Asn Ser Pro Ile Arg Thr
            180                 185                 190         
Phe Gly Leu Asn Leu Ser Ser Asp Ser Ser Ala Leu Gly Ala Val Ala
        195                 200                 205             
Ser Asp Ser Glu Gln Ser Lys Thr Glu Glu Glu Arg Glu Ser Arg Ser
    210                 215                 220                 
Leu Phe Pro Gly Ser Leu Lys Pro Lys Leu Gly Lys Arg Asp Tyr Leu
225                 230                 235                 240 
Glu Lys Ala Gly Glu Leu Ile Lys Leu Val Leu Lys Lys Glu Glu Glu
                245                 250                 255     
Asp Asp Tyr Glu Ala Ala Ser Asp Phe Tyr Arg Lys Gly Val Asp Leu
            260                 265                 270         
Leu Leu Glu Gly Val Gln Gly Glu Ser Ser Pro Thr Arg Arg Glu Ala
        275                 280                 285             
Val Lys Arg Arg Thr Ala Glu Tyr Leu Met Arg Ala Glu Ser Ile Ser
    290                 295                 300                 
Ser Leu Tyr Gly Lys Pro Gln Leu Asp Asp Val Ser Gln Pro Pro Gly
305                 310                 315                 320 
Ser Leu Ser Ser Arg Pro Leu Trp Asn Leu Arg Ser Pro Ala Glu Glu
                325                 330                 335     
Leu Lys Ala Phe Arg Val Leu Gly Val Ile Asp Lys Val Leu Leu Val
            340                 345                 350         
Met Asp Thr Arg Thr Glu Gln Thr Phe Ile Leu Lys Gly Leu Arg Lys
        355                 360                 365             
Ser Ser Glu Tyr Ser Arg Asn Arg Lys Thr Ile Ile Pro Arg Cys Val
    370                 375                 380                 
Pro Asn Met Val Cys Leu His Lys Tyr Ile Ile Ser Glu Glu Ser Val
385                 390                 395                 400 
Phe Leu Val Leu Gln His Ala Glu Gly Gly Lys Leu Trp Ser Tyr Ile
                405                 410                 415     
Ser Lys Phe Leu Asn Arg Ser Pro Glu Glu Ser Phe Asp Ile Lys Glu
            420                 425                 430         
Val Lys Lys Pro Thr Leu Ala Lys Val His Leu Gln Gln Pro Thr Ser
        435                 440                 445             
Ser Pro Gln Asp Ser Ser Ser Phe Glu Ser Arg Gly Ser Asp Gly Gly
    450                 455                 460                 
Ser Met Leu Lys Ala Leu Pro Leu Lys Ser Ser Leu Thr Pro Ser Ser
465                 470                 475                 480 
Gln Asp Asp Ser Asn Gln Glu Asp Asp Gly Gln Asp Ser Ser Pro Lys
                485                 490                 495     
Trp Pro Asp Ser Gly Ser Ser Ser Glu Glu Glu Cys Thr Thr Ser Tyr
            500                 505                 510         
Leu Thr Leu Cys Asn Glu Tyr Gly Gln Glu Lys Ile Glu Pro Gly Ser
        515                 520                 525             
Leu Asn Glu Glu Pro Phe Met Lys Thr Glu Gly Asn Gly Val Asp Thr
    530                 535                 540                 
Lys Ala Ile Lys Ser Phe Pro Ala His Leu Ala Ala Asp Ser Asp Ser
545                 550                 555                 560 
Pro Ser Thr Gln Leu Arg Ala His Glu Leu Lys Phe Phe Pro Asn Asp
                565                 570                 575     
Asp Pro Glu Ala Val Ser Ser Pro Arg Thr Ser Asp Ser Leu Ser Arg
            580                 585                 590         
Ser Lys Asn Ser Pro Met Glu Phe Phe Arg Ile Asp Ser Lys Asp Ser
        595                 600                 605             
Ala Ser Glu Leu Leu Gly Leu Asp Phe Gly Glu Lys Leu Tyr Ser Leu
    610                 615                 620                 
Lys Ser Glu Pro Leu Lys Pro Phe Phe Thr Leu Pro Asp Gly Asp Ser
625                 630                 635                 640 
Ala Ser Arg Ser Phe Asn Thr Ser Glu Ser Lys Val Glu Phe Lys Ala
                645                 650                 655     
Gln Asp Thr Ile Ser Arg Gly Ser Asp Asp Ser Val Pro Val Ile Ser
            660                 665                 670         
Phe Lys Asp Ala Ala Phe Asp Asp Val Ser Gly Thr Asp Glu Gly Arg
        675                 680                 685             
Pro Asp Leu Leu Val Asn Leu Pro Gly Glu Leu Glu Ser Thr Arg Glu
    690                 695                 700                 
Ala Ala Ala Met Gly Pro Thr Lys Phe Thr Gln Thr Asn Ile Gly Ile
705                 710                 715                 720 
Ile Glu Asn Lys Leu Leu Glu Ala Pro Asp Val Leu Cys Leu Arg Leu
                725                 730                 735     
Ser Thr Glu Gln Cys Gln Ala His Glu Glu Lys Gly Ile Glu Glu Leu
            740                 745                 750         
Ser Asp Pro Ser Gly Pro Lys Ser Tyr Ser Ile Thr Glu Lys His Tyr
        755                 760                 765             
Ala Gln Glu Asp Pro Arg Met Leu Phe Val Ala Ala Val Asp His Ser
    770                 775                 780                 
Ser Ser Gly Asp Met Ser Leu Leu Pro Ser Ser Asp Pro Lys Phe Gln
785                 790                 795                 800 
Gly Leu Gly Val Val Glu Ser Ala Val Thr Ala Asn Asn Thr Glu Glu
                805                 810                 815     
Ser Leu Phe Arg Ile Cys Ser Pro Leu Ser Gly Ala Asn Glu Tyr Ile
            820                 825                 830         
Ala Ser Thr Asp Thr Leu Lys Thr Glu Glu Val Leu Leu Phe Thr Asp
        835                 840                 845             
Gln Thr Asp Asp Leu Ala Lys Glu Glu Pro Thr Ser Leu Phe Gln Arg
    850                 855                 860                 
Asp Ser Glu Thr Lys Gly Glu Ser Gly Leu Val Leu Glu Gly Asp Lys
865                 870                 875                 880 
Glu Ile His Gln Ile Phe Glu Asp Leu Asp Lys Lys Leu Ala Leu Ala
                885                 890                 895     
Ser Arg Phe Tyr Ile Pro Glu Gly Cys Ile Gln Arg Trp Ala Ala Glu
            900                 905                 910         
Met Val Val Ala Leu Asp Ala Leu His Arg Glu Gly Ile Val Cys Arg
        915                 920                 925             
Asp Leu Asn Pro Asn Asn Ile Leu Leu Asn Asp Arg Gly His Ile Gln
    930                 935                 940                 
Leu Thr Tyr Phe Ser Arg Trp Ser Glu Val Glu Asp Ser Cys Asp Ser
945                 950                 955                 960 
Asp Ala Ile Glu Arg Met Tyr Cys Ala Pro Glu Val Gly Ala Ile Thr
                965                 970                 975     
Glu Glu Thr Glu Ala Cys Asp Trp Trp Ser Leu Gly Ala Val Leu Phe
            980                 985                 990         
Glu Leu Leu Thr Gly Lys Thr Leu Val Glu Cys His Pro Ala Gly Ile
        995                 1000                1005            
Asn Thr His Thr Thr Leu Asn Met Pro Glu Cys Val Ser Glu Glu Ala
    1010                1015                1020                
Arg Ser Leu Ile Gln Gln Leu Leu Gln Phe Asn Pro Leu Glu Arg Leu
1025                1030                1035                1040
Gly Ala Gly Val Ala Gly Val Glu Asp Ile Lys Ser His Pro Phe Phe
                1045                1050                1055    
Thr Pro Val Asp Trp Ala Glu Leu Met Arg
            1060                1065    


<210> 2367
<211> 956
<212> PRT
<213> Homo sapiens

<400> 2367
Met Pro Gly Gly Ala Gly Ala Ala Arg Leu Cys Leu Leu Ala Phe Ala
 1               5                  10                  15      
Leu Gln Pro Leu Arg Pro Arg Ala Ala Arg Glu Pro Gly Trp Thr Ser
            20                  25                  30          
Lys Gly Ser Glu Glu Gly Ser Pro Lys Leu Gln His Glu Leu Ile Ile
        35                  40                  45              
Pro Gln Trp Lys Thr Ser Glu Ser Pro Val Arg Glu Lys His Pro Leu
    50                  55                  60                  
Lys Ala Glu Leu Arg Val Met Ala Glu Gly Arg Glu Leu Ile Leu Asp
65                  70                  75                  80  
Leu Glu Lys Asn Glu Gln Leu Phe Ala Pro Ser Tyr Thr Glu Thr His
                85                  90                  95      
Tyr Thr Ser Ser Gly Asn Pro Gln Thr Thr Thr Arg Lys Leu Glu Asp
            100                 105                 110         
His Cys Phe Tyr His Gly Thr Val Arg Glu Thr Glu Leu Ser Ser Val
        115                 120                 125             
Thr Leu Ser Thr Cys Arg Gly Ile Arg Gly Leu Ile Thr Val Ser Ser
    130                 135                 140                 
Asn Leu Ser Tyr Val Ile Glu Pro Leu Pro Asp Ser Lys Gly Gln His
145                 150                 155                 160 
Leu Ile Tyr Arg Ser Glu His Leu Lys Pro Pro Pro Gly Asn Cys Gly
                165                 170                 175     
Phe Glu His Ser Lys Pro Thr Thr Arg Asp Trp Ala Leu Gln Phe Thr
            180                 185                 190         
Gln Gln Thr Lys Lys Arg Pro Arg Arg Met Lys Arg Glu Asp Leu Asn
        195                 200                 205             
Ser Met Lys Tyr Val Glu Leu Tyr Leu Val Ala Asp Tyr Leu Glu Phe
    210                 215                 220                 
Gln Lys Asn Arg Arg Asp Gln Asp Ala Thr Lys His Lys Leu Ile Glu
225                 230                 235                 240 
Ile Ala Asn Tyr Val Asp Lys Phe Tyr Arg Ser Leu Asn Ile Arg Ile
                245                 250                 255     
Ala Leu Val Gly Leu Glu Val Trp Thr His Gly Asn Met Cys Glu Val
            260                 265                 270         
Ser Glu Asn Pro Tyr Ser Thr Leu Trp Ser Phe Leu Ser Trp Arg Arg
        275                 280                 285             
Lys Leu Leu Ala Gln Lys Tyr His Asp Asn Ala Gln Leu Ile Thr Gly
    290                 295                 300                 
Met Ser Phe His Gly Thr Thr Ile Gly Leu Ala Pro Leu Met Ala Met
305                 310                 315                 320 
Cys Ser Val Tyr Gln Ser Gly Gly Val Asn Met Asp His Ser Glu Asn
                325                 330                 335     
Ala Ile Gly Val Ala Ala Thr Met Ala His Glu Met Gly His Asn Phe
            340                 345                 350         
Gly Met Thr His Asp Ser Ala Asp Cys Cys Ser Ala Ser Ala Ala Asp
        355                 360                 365             
Gly Gly Cys Ile Met Ala Ala Ala Thr Gly His Pro Phe Pro Lys Val
    370                 375                 380                 
Phe Asn Gly Cys Asn Arg Arg Glu Leu Asp Arg Tyr Leu Gln Ser Gly
385                 390                 395                 400 
Gly Gly Met Cys Leu Ser Asn Met Pro Asp Thr Arg Met Leu Tyr Gly
                405                 410                 415     
Gly Arg Arg Cys Gly Asn Gly Tyr Leu Glu Asp Gly Glu Glu Cys Asp
            420                 425                 430         
Cys Gly Glu Glu Glu Glu Cys Asn Asn Pro Cys Cys Asn Ala Ser Asn
        435                 440                 445             
Cys Thr Leu Arg Pro Gly Ala Glu Cys Ala His Gly Ser Cys Cys His
    450                 455                 460                 
Gln Cys Lys Leu Leu Ala Pro Gly Thr Leu Cys Arg Glu Gln Ala Arg
465                 470                 475                 480 
Gln Cys Asp Leu Pro Glu Phe Cys Thr Gly Lys Ser Pro His Cys Pro
                485                 490                 495     
Thr Asn Phe Tyr Gln Met Asp Gly Thr Pro Cys Glu Gly Gly Gln Ala
            500                 505                 510         
Tyr Cys Tyr Asn Gly Met Cys Leu Thr Tyr Gln Glu Gln Cys Gln Gln
        515                 520                 525             
Leu Trp Gly Pro Gly Ala Arg Pro Ala Pro Asp Leu Cys Phe Glu Lys
    530                 535                 540                 
Val Asn Val Ala Gly Asp Thr Phe Gly Asn Cys Gly Lys Asp Met Asn
545                 550                 555                 560 
Gly Glu His Arg Lys Cys Asn Met Arg Asp Ala Lys Cys Gly Lys Ile
                565                 570                 575     
Gln Cys Gln Ser Ser Glu Ala Arg Pro Leu Glu Ser Asn Ala Val Pro
            580                 585                 590         
Ile Asp Thr Thr Ile Ile Met Asn Gly Arg Gln Ile Gln Cys Arg Gly
        595                 600                 605             
Thr His Val Tyr Arg Gly Pro Glu Glu Glu Gly Asp Met Leu Asp Pro
    610                 615                 620                 
Gly Leu Val Met Thr Gly Thr Lys Cys Gly Tyr Asn His Ile Cys Phe
625                 630                 635                 640 
Glu Gly Gln Cys Arg Asn Thr Ser Phe Phe Glu Thr Glu Gly Cys Gly
                645                 650                 655     
Lys Lys Cys Asn Gly His Gly Val Cys Asn Asn Asn Gln Asn Cys His
            660                 665                 670         
Cys Leu Pro Gly Trp Ala Pro Pro Phe Cys Asn Thr Pro Gly His Gly
        675                 680                 685             
Gly Ser Ile Asp Ser Gly Pro Met Pro Pro Glu Ser Val Gly Pro Val
    690                 695                 700                 
Val Ala Gly Val Leu Val Ala Ile Leu Val Leu Ala Val Leu Met Leu
705                 710                 715                 720 
Met Tyr Tyr Cys Cys Arg Gln Asn Asn Lys Leu Gly Gln Leu Lys Pro
                725                 730                 735     
Ser Ala Leu Pro Ser Lys Leu Arg Gln Gln Phe Ser Cys Pro Phe Arg
            740                 745                 750         
Val Ser Gln Asn Ser Gly Thr Gly His Ala Asn Pro Thr Phe Lys Leu
        755                 760                 765             
Gln Thr Pro Gln Gly Lys Arg Lys Val Ile Asn Thr Pro Glu Ile Leu
    770                 775                 780                 
Arg Lys Pro Ser Gln Pro Pro Pro Arg Pro Pro Pro Asp Tyr Leu Arg
785                 790                 795                 800 
Gly Gly Ser Pro Pro Ala Pro Leu Pro Ala His Leu Ser Arg Ala Ala
                805                 810                 815     
Arg Asn Ser Pro Gly Pro Gly Ser Gln Ile Glu Arg Thr Glu Ser Ser
            820                 825                 830         
Arg Arg Pro Pro Pro Ser Arg Pro Ile Pro Pro Ala Pro Asn Cys Ile
        835                 840                 845             
Val Ser Gln Asp Phe Ser Arg Pro Arg Pro Pro Gln Lys Ala Leu Pro
    850                 855                 860                 
Ala Asn Pro Val Pro Gly Arg Arg Ser Leu Pro Arg Pro Gly Gly Ala
865                 870                 875                 880 
Ser Pro Leu Arg Pro Pro Gly Ala Gly Pro Gln Gln Ser Arg Pro Leu
                885                 890                 895     
Ala Ala Leu Ala Pro Lys Val Ser Pro Arg Glu Ala Leu Lys Val Lys
            900                 905                 910         
Ala Gly Thr Arg Gly Leu Gln Gly Gly Arg Cys Arg Val Glu Lys Thr
        915                 920                 925             
Lys Gln Phe Met Leu Leu Val Val Trp Thr Glu Leu Pro Glu Gln Lys
    930                 935                 940                 
Pro Arg Ala Lys His Ser Cys Phe Leu Val Pro Ala
945                 950                 955     


<210> 2368
<211> 552
<212> PRT
<213> Homo sapiens

<400> 2368
Met Glu Thr Leu Glu Ser Glu Leu Thr Cys Pro Ile Cys Leu Glu Leu
 1               5                  10                  15      
Phe Glu Asp Pro Leu Leu Leu Pro Cys Ala His Ser Leu Cys Phe Asn
            20                  25                  30          
Cys Ala His Arg Ile Leu Val Ser His Cys Ala Thr Asn Glu Ser Val
        35                  40                  45              
Glu Ser Ile Thr Ala Phe Gln Cys Pro Thr Cys Arg His Val Ile Thr
    50                  55                  60                  
Leu Ser Gln Arg Gly Leu Asp Gly Leu Lys Arg Asn Val Thr Leu Gln
65                  70                  75                  80  
Asn Ile Ile Asp Arg Phe Gln Lys Ala Ser Val Ser Gly Pro Asn Ser
                85                  90                  95      
Pro Ser Glu Thr Arg Arg Glu Arg Ala Phe Asp Ala Asn Thr Met Thr
            100                 105                 110         
Ser Ala Glu Lys Val Leu Cys Gln Phe Cys Asp Gln Asp Pro Ala Gln
        115                 120                 125             
Asp Ala Val Lys Thr Cys Val Thr Cys Glu Val Ser Tyr Cys Asp Glu
    130                 135                 140                 
Cys Leu Lys Ala Thr His Pro Asn Lys Lys Pro Phe Thr Gly His Arg
145                 150                 155                 160 
Leu Ile Glu Pro Ile Pro Asp Ser His Ile Arg Gly Leu Met Cys Leu
                165                 170                 175     
Glu His Glu Asp Glu Lys Val Asn Met Tyr Cys Val Thr Asp Asp Gln
            180                 185                 190         
Leu Ile Cys Ala Leu Cys Lys Leu Val Gly Arg His Arg Asp His Gln
        195                 200                 205             
Val Ala Ala Leu Ser Glu Arg Tyr Asp Lys Leu Lys Gln Asn Leu Glu
    210                 215                 220                 
Ser Asn Leu Thr Asn Leu Ile Lys Arg Asn Thr Glu Leu Glu Thr Leu
225                 230                 235                 240 
Leu Ala Lys Leu Ile Gln Thr Cys Gln His Val Glu Val Asn Ala Ser
                245                 250                 255     
Arg Gln Glu Ala Lys Leu Thr Glu Glu Cys Asp Leu Leu Ile Glu Ile
            260                 265                 270         
Ile Gln Gln Arg Arg Gln Ile Ile Gly Thr Lys Ile Lys Glu Gly Lys
        275                 280                 285             
Val Met Arg Leu Arg Lys Leu Ala Gln Gln Ile Ala Asn Cys Lys Gln
    290                 295                 300                 
Cys Ile Glu Arg Ser Ala Ser Leu Ile Ser Gln Ala Glu His Ser Leu
305                 310                 315                 320 
Lys Glu Asn Asp His Ala Arg Phe Leu Gln Thr Ala Lys Asn Ile Thr
                325                 330                 335     
Glu Arg Val Ser Met Ala Thr Ala Ser Ser Gln Val Leu Ile Pro Glu
            340                 345                 350         
Ile Asn Leu Asn Asp Thr Phe Asp Thr Phe Ala Leu Asp Phe Ser Arg
        355                 360                 365             
Glu Lys Lys Leu Leu Glu Cys Leu Asp Tyr Leu Thr Ala Pro Asn Pro
    370                 375                 380                 
Pro Thr Ile Arg Glu Glu Leu Cys Thr Ala Ser Tyr Asp Thr Ile Thr
385                 390                 395                 400 
Val His Trp Thr Ser Asp Asp Glu Phe Ser Val Val Ser Tyr Glu Leu
                405                 410                 415     
Gln Tyr Thr Ile Phe Thr Gly Gln Ala Asn Val Val Ser Leu Cys Asn
            420                 425                 430         
Ser Ala Asp Ser Trp Met Ile Val Pro Asn Ile Lys Gln Asn His Tyr
        435                 440                 445             
Thr Val His Gly Leu Gln Ser Gly Thr Lys Tyr Ile Phe Met Val Lys
    450                 455                 460                 
Ala Ile Asn Gln Ala Gly Ser Arg Ser Ser Glu Pro Gly Lys Leu Lys
465                 470                 475                 480 
Thr Asn Ser Gln Pro Phe Lys Leu Asp Pro Lys Ser Ala His Arg Lys
                485                 490                 495     
Leu Lys Val Ser His Asp Asn Leu Thr Val Glu Arg Asp Glu Ser Ser
            500                 505                 510         
Ser Lys Lys Ser His Thr Pro Glu Arg Phe Thr Ser Gln Gly Ser Tyr
        515                 520                 525             
Gly Val Ala Gly Asn Val Phe Ile Asp Ser Gly Arg His Tyr Trp Glu
    530                 535                 540                 
Val Val Ile Ser Gly Ser Thr Trp
545                 550         


<210> 2369
<211> 1038
<212> PRT
<213> Homo sapiens

<400> 2369
Met Thr Ser Ser Leu Gln Arg Pro Trp Arg Val Pro Trp Leu Pro Trp
 1               5                  10                  15      
Thr Ile Leu Leu Val Ser Thr Ala Ala Ala Ser Gln Asn Gln Glu Arg
            20                  25                  30          
Leu Cys Ala Phe Lys Asp Pro Tyr Gln Gln Asp Leu Gly Ile Gly Glu
        35                  40                  45              
Ser Arg Ile Ser His Glu Asn Gly Thr Ile Leu Cys Ser Lys Gly Ser
    50                  55                  60                  
Thr Cys Tyr Gly Leu Trp Glu Lys Ser Lys Gly Asp Ile Asn Leu Val
65                  70                  75                  80  
Lys Gln Gly Cys Trp Ser His Ile Gly Asp Pro Gln Glu Cys His Tyr
                85                  90                  95      
Glu Glu Cys Val Val Thr Thr Thr Pro Pro Ser Ile Gln Asn Gly Thr
            100                 105                 110         
Tyr Arg Phe Cys Cys Cys Ser Thr Asp Leu Cys Asn Val Asn Phe Thr
        115                 120                 125             
Glu Asn Phe Pro Pro Pro Asp Thr Thr Pro Leu Ser Pro Pro His Ser
    130                 135                 140                 
Phe Asn Arg Asp Glu Thr Ile Ile Ile Ala Leu Ala Ser Val Ser Val
145                 150                 155                 160 
Leu Ala Val Leu Ile Val Ala Leu Cys Phe Gly Tyr Arg Met Leu Thr
                165                 170                 175     
Gly Asp Arg Lys Gln Gly Leu His Ser Met Asn Met Met Glu Ala Ala
            180                 185                 190         
Ala Ser Glu Pro Ser Leu Asp Leu Asp Asn Leu Lys Leu Leu Glu Leu
        195                 200                 205             
Ile Gly Arg Gly Arg Tyr Gly Ala Val Tyr Lys Gly Ser Leu Asp Glu
    210                 215                 220                 
Arg Pro Val Ala Val Lys Val Phe Ser Phe Ala Asn Arg Gln Asn Phe
225                 230                 235                 240 
Ile Asn Glu Lys Asn Ile Tyr Arg Val Pro Leu Met Glu His Asp Asn
                245                 250                 255     
Ile Ala Arg Phe Ile Val Gly Asp Glu Arg Val Thr Ala Asp Gly Arg
            260                 265                 270         
Met Glu Tyr Leu Leu Val Met Glu Tyr Tyr Pro Asn Gly Ser Leu Cys
        275                 280                 285             
Lys Tyr Leu Ser Leu His Thr Ser Asp Trp Val Ser Ser Cys Arg Leu
    290                 295                 300                 
Ala His Ser Val Thr Arg Gly Leu Ala Tyr Leu His Thr Glu Leu Pro
305                 310                 315                 320 
Arg Gly Asp His Tyr Lys Pro Ala Ile Ser His Arg Asp Leu Asn Ser
                325                 330                 335     
Arg Asn Val Leu Val Lys Asn Asp Gly Thr Cys Val Ile Ser Asp Phe
            340                 345                 350         
Gly Leu Ser Met Arg Leu Thr Gly Asn Arg Leu Val Arg Pro Gly Glu
        355                 360                 365             
Glu Asp Asn Ala Ala Ile Ser Glu Val Gly Thr Ile Arg Tyr Met Ala
    370                 375                 380                 
Pro Glu Val Leu Glu Gly Ala Val Asn Leu Arg Asp Cys Glu Ser Ala
385                 390                 395                 400 
Leu Lys Gln Val Asp Met Tyr Ala Leu Gly Leu Ile Tyr Trp Glu Ile
                405                 410                 415     
Phe Met Arg Cys Thr Asp Leu Phe Pro Gly Glu Ser Val Pro Glu Tyr
            420                 425                 430         
Gln Met Ala Phe Gln Thr Glu Val Gly Asn His Pro Thr Phe Glu Asp
        435                 440                 445             
Met Gln Val Leu Val Ser Arg Glu Lys Gln Arg Pro Lys Phe Pro Glu
    450                 455                 460                 
Ala Trp Lys Glu Asn Ser Leu Ala Val Arg Ser Leu Lys Glu Thr Ile
465                 470                 475                 480 
Glu Asp Cys Trp Asp Gln Asp Ala Glu Ala Arg Leu Thr Ala Gln Cys
                485                 490                 495     
Ala Glu Glu Arg Met Ala Glu Leu Met Met Ile Trp Glu Arg Asn Lys
            500                 505                 510         
Ser Val Ser Pro Thr Val Asn Pro Met Ser Thr Ala Met Gln Asn Glu
        515                 520                 525             
Arg Asn Leu Ser His Asn Arg Arg Val Pro Lys Ile Gly Pro Tyr Pro
    530                 535                 540                 
Asp Tyr Ser Ser Ser Ser Tyr Ile Glu Asp Ser Ile His His Thr Asp
545                 550                 555                 560 
Ser Ile Val Lys Asn Ile Ser Ser Glu His Ser Met Ser Ser Thr Pro
                565                 570                 575     
Leu Thr Ile Gly Glu Lys Asn Arg Asn Ser Ile Asn Tyr Glu Arg Gln
            580                 585                 590         
Gln Ala Gln Ala Arg Ile Pro Ser Pro Glu Thr Ser Val Thr Ser Leu
        595                 600                 605             
Ser Thr Asn Thr Thr Thr Thr Asn Thr Thr Gly Leu Thr Pro Ser Thr
    610                 615                 620                 
Gly Met Thr Thr Ile Ser Glu Met Pro Tyr Pro Asp Glu Thr Asn Leu
625                 630                 635                 640 
His Thr Thr Asn Val Ala Gln Ser Ile Gly Pro Thr Pro Val Cys Leu
                645                 650                 655     
Gln Leu Thr Glu Glu Asp Leu Glu Thr Asn Lys Leu Asp Pro Lys Glu
            660                 665                 670         
Val Asp Lys Asn Leu Lys Glu Ser Ser Asp Glu Asn Leu Met Glu His
        675                 680                 685             
Ser Leu Lys Gln Phe Ser Gly Pro Asp Pro Leu Ser Ser Thr Ser Ser
    690                 695                 700                 
Ser Leu Leu Tyr Pro Leu Ile Lys Leu Ala Val Glu Ala Thr Gly Gln
705                 710                 715                 720 
Gln Asp Phe Thr Gln Thr Ala Asn Gly Gln Ala Cys Leu Ile Pro Asp
                725                 730                 735     
Val Leu Pro Thr Gln Ile Tyr Pro Leu Pro Lys Gln Gln Asn Leu Pro
            740                 745                 750         
Lys Arg Pro Thr Ser Leu Pro Leu Asn Thr Lys Asn Ser Thr Lys Glu
        755                 760                 765             
Pro Arg Leu Lys Phe Gly Ser Lys His Lys Ser Asn Leu Lys Gln Val
    770                 775                 780                 
Glu Thr Gly Val Ala Lys Met Asn Thr Ile Asn Ala Ala Glu Pro His
785                 790                 795                 800 
Val Val Thr Val Thr Met Asn Gly Val Ala Gly Arg Asn His Ser Val
                805                 810                 815     
Asn Ser His Ala Ala Thr Thr Gln Tyr Ala Asn Gly Thr Val Leu Ser
            820                 825                 830         
Gly Gln Thr Thr Asn Ile Val Thr His Arg Ala Gln Glu Met Leu Gln
        835                 840                 845             
Asn Gln Phe Ile Gly Glu Asp Thr Arg Leu Asn Ile Asn Ser Ser Pro
    850                 855                 860                 
Asp Glu His Glu Pro Leu Leu Arg Arg Glu Gln Gln Ala Gly His Asp
865                 870                 875                 880 
Glu Gly Val Leu Asp Arg Leu Val Asp Arg Arg Glu Arg Pro Leu Glu
                885                 890                 895     
Gly Gly Arg Thr Asn Ser Asn Asn Asn Asn Ser Asn Pro Cys Ser Glu
            900                 905                 910         
Gln Asp Val Leu Ala Gln Gly Val Pro Ser Thr Ala Ala Asp Pro Gly
        915                 920                 925             
Pro Ser Lys Pro Arg Arg Ala Gln Arg Pro Asn Ser Leu Asp Leu Ser
    930                 935                 940                 
Ala Thr Asn Val Leu Asp Gly Ser Ser Ile Gln Ile Gly Glu Ser Thr
945                 950                 955                 960 
Gln Asp Gly Lys Ser Gly Ser Gly Glu Lys Ile Lys Lys Arg Val Lys
                965                 970                 975     
Thr Pro Tyr Ser Leu Lys Arg Trp Arg Pro Ser Thr Trp Val Ile Ser
            980                 985                 990         
Thr Glu Ser Leu Asp Cys Glu Val Asn Asn Asn Gly Ser Asn Arg Ala
        995                 1000                1005            
Val His Ser Lys Ser Ser Thr Ala Val Tyr Leu Ala Glu Gly Gly Thr
    1010                1015                1020                
Ala Thr Thr Met Val Ser Lys Asp Ile Gly Met Asn Cys Leu
1025                1030                1035            


<210> 2370
<211> 687
<212> PRT
<213> Homo sapiens

<400> 2370
Met Ala Ala Glu Val Ala Leu Ser Glu Ser Ala Lys Asp Gln Lys Ala
 1               5                  10                  15      
Ala Asn Pro Tyr Val Thr Pro Asn Asn Arg Tyr Gly Tyr Gln Asn Gly
            20                  25                  30          
Ala Ser Tyr Thr Trp Gln Phe Glu Ala Arg Lys Ala Gln Ile Leu Lys
        35                  40                  45              
Cys Met Glu Cys Gly Ser Ser His Asp Thr Leu Gln Gln Leu Thr Ala
    50                  55                  60                  
His Met Met Val Thr Gly His Phe Leu Lys Val Thr Thr Ser Ala Ser
65                  70                  75                  80  
Lys Lys Gly Lys Gln Leu Val Leu Asp Pro Val Val Glu Glu Lys Ile
                85                  90                  95      
Gln Ser Ile Pro Leu Pro Pro Thr Thr His Thr Arg Leu Pro Ala Ser
            100                 105                 110         
Ser Ile Lys Lys Gln Pro Asp Ser Pro Ala Gly Ser Thr Thr Ser Glu
        115                 120                 125             
Glu Lys Lys Glu Pro Glu Lys Glu Lys Pro Pro Val Ala Gly Asp Ala
    130                 135                 140                 
Glu Lys Ile Lys Glu Glu Ser Glu Asp Ser Leu Glu Lys Phe Glu Pro
145                 150                 155                 160 
Ser Thr Leu Tyr Pro Tyr Leu Arg Glu Glu Asp Leu Asp Asp Ser Pro
                165                 170                 175     
Lys Gly Gly Leu Asp Ile Leu Lys Ser Leu Glu Asn Thr Val Ser Thr
            180                 185                 190         
Ala Ile Ser Lys Ala Gln Asn Gly Ala Pro Ser Trp Gly Gly Tyr Pro
        195                 200                 205             
Ser Ile His Ala Ala Tyr Gln Leu Pro Gly Thr Val Lys Pro Leu Pro
    210                 215                 220                 
Ala Ala Val Gln Ser Val Gln Val Gln Pro Ser Tyr Ala Gly Gly Val
225                 230                 235                 240 
Lys Ser Leu Ser Ser Ala Glu His Asn Ala Leu Leu His Ser Pro Gly
                245                 250                 255     
Ser Leu Thr Pro Pro Pro His Lys Ser Asn Val Ser Ala Met Glu Glu
            260                 265                 270         
Leu Val Glu Lys Val Thr Gly Lys Val Asn Ile Lys Lys Glu Glu Arg
        275                 280                 285             
Pro Pro Glu Lys Glu Lys Ser Ser Leu Ala Lys Ala Ala Ser Pro Ile
    290                 295                 300                 
Ala Lys Glu Asn Lys Asp Phe Pro Lys Thr Glu Glu Val Ser Gly Lys
305                 310                 315                 320 
Pro Gln Lys Lys Gly Pro Glu Ala Glu Thr Gly Lys Ala Lys Lys Glu
                325                 330                 335     
Gly Pro Leu Asp Val His Thr Pro Asn Gly Thr Glu Pro Leu Lys Ala
            340                 345                 350         
Lys Val Thr Asn Gly Cys Asn Asn Leu Gly Ile Ile Met Asp His Ser
        355                 360                 365             
Pro Glu Pro Ser Phe Ile Asn Pro Leu Ser Ala Leu Gln Ser Ile Met
    370                 375                 380                 
Asn Thr His Leu Gly Lys Val Ser Lys Pro Val Ser Pro Ser Leu Asp
385                 390                 395                 400 
Pro Leu Ala Met Leu Tyr Lys Ile Ser Asn Ser Met Leu Asp Lys Pro
                405                 410                 415     
Val Tyr Pro Ala Thr Pro Val Lys Gln Ala Asp Ala Ile Asp Arg Tyr
            420                 425                 430         
Tyr Tyr Glu Asn Ser Asp Gln Pro Ile Asp Leu Thr Lys Ser Lys Asn
        435                 440                 445             
Lys Pro Leu Val Ser Ser Val Ala Asp Ser Val Ala Ser Pro Leu Arg
    450                 455                 460                 
Glu Ser Ala Leu Met Asp Ile Ser Asp Met Val Lys Asn Leu Thr Gly
465                 470                 475                 480 
Arg Leu Thr Pro Lys Ser Ser Thr Pro Ser Thr Val Ser Glu Lys Ser
                485                 490                 495     
Asp Ala Asp Gly Ser Ser Phe Glu Glu Ala Leu Asp Glu Leu Ser Pro
            500                 505                 510         
Val His Lys Arg Lys Gly Arg Gln Ser Asn Trp Asn Pro Gln His Leu
        515                 520                 525             
Leu Ile Leu Gln Ala Gln Phe Ala Ser Ser Leu Arg Glu Thr Thr Glu
    530                 535                 540                 
Gly Lys Tyr Ile Met Ser Asp Leu Gly Pro Gln Glu Arg Val His Ile
545                 550                 555                 560 
Ser Lys Phe Thr Gly Leu Ser Met Thr Thr Ile Ser His Trp Leu Ala
                565                 570                 575     
Asn Val Lys Tyr Gln Leu Arg Arg Thr Gly Gly Thr Lys Phe Leu Lys
            580                 585                 590         
Asn Leu Asp Thr Gly His Pro Val Phe Phe Cys Asn Asp Cys Ala Ser
        595                 600                 605             
Gln Phe Arg Thr Ala Ser Thr Tyr Ile Ser His Leu Glu Thr His Leu
    610                 615                 620                 
Gly Phe Ser Leu Lys Asp Leu Ser Lys Leu Pro Leu Asn Gln Ile Gln
625                 630                 635                 640 
Glu Gln Gln Asn Val Ser Lys Val Leu Thr Asn Lys Thr Leu Gly Pro
                645                 650                 655     
Leu Gly Ala Thr Glu Glu Asp Leu Gly Ser Thr Phe Gln Cys Lys Leu
            660                 665                 670         
Cys Asn Arg Thr Phe Ala Lys Gln Ala Arg Ser Gln Thr Ala Pro
        675                 680                 685         


<210> 2371
<211> 1333
<212> PRT
<213> Homo sapiens

<400> 2371
Met Gln Ala Gln Gln Leu Pro Tyr Glu Phe Phe Ser Glu Glu Asn Ala
 1               5                  10                  15      
Pro Lys Trp Arg Gly Leu Leu Val Pro Ala Leu Lys Lys Val Gln Gly
            20                  25                  30          
Gln Val His Pro Thr Leu Glu Ser Asn Asp Asp Ala Leu Gln Tyr Val
        35                  40                  45              
Glu Glu Leu Ile Leu Gln Leu Leu Asn Met Leu Cys Gln Ala Gln Pro
    50                  55                  60                  
Arg Ser Ala Ser Asp Val Glu Glu Arg Val Gln Lys Ser Phe Pro His
65                  70                  75                  80  
Pro Ile Asp Lys Trp Ala Ile Ala Asp Ala Gln Ser Ala Ile Glu Lys
                85                  90                  95      
Arg Lys Arg Arg Asn Pro Leu Ser Leu Pro Val Glu Lys Ile His Pro
            100                 105                 110         
Leu Leu Lys Glu Val Leu Gly Tyr Lys Ile Asp His Gln Val Ser Val
        115                 120                 125             
Tyr Ile Val Ala Val Leu Glu Tyr Ile Ser Ala Asp Ile Leu Lys Leu
    130                 135                 140                 
Val Gly Asn Tyr Val Arg Asn Ile Arg His Tyr Glu Ile Thr Lys Gln
145                 150                 155                 160 
Asp Ile Lys Val Ala Met Cys Ala Asp Lys Val Leu Met Asp Met Phe
                165                 170                 175     
His Gln Asp Val Glu Asp Ile Asn Ile Leu Ser Leu Thr Asp Glu Glu
            180                 185                 190         
Pro Ser Thr Ser Gly Glu Gln Thr Tyr Tyr Asp Leu Val Lys Ala Phe
        195                 200                 205             
Met Ala Glu Ile Arg Gln Tyr Ile Arg Glu Leu Asn Leu Ile Ile Lys
    210                 215                 220                 
Val Phe Arg Glu Pro Phe Val Ser Asn Ser Lys Leu Phe Ser Ala Asn
225                 230                 235                 240 
Asp Val Glu Asn Ile Phe Ser Arg Ile Val Asp Ile His Glu Leu Ser
                245                 250                 255     
Val Lys Leu Leu Gly His Ile Glu Asp Thr Val Glu Met Thr Asp Glu
            260                 265                 270         
Gly Ser Pro His Pro Leu Val Gly Ser Cys Phe Glu Asp Leu Ala Glu
        275                 280                 285             
Glu Leu Ala Phe Asp Pro Tyr Glu Ser Tyr Ala Arg Asp Ile Leu Arg
    290                 295                 300                 
Pro Gly Phe His Asp Arg Phe Leu Ser Gln Leu Ser Lys Pro Gly Ala
305                 310                 315                 320 
Ala Leu Tyr Leu Gln Ser Ile Gly Glu Gly Phe Lys Glu Ala Val Gln
                325                 330                 335     
Tyr Val Leu Pro Arg Leu Leu Leu Ala Pro Val Tyr His Cys Leu His
            340                 345                 350         
Tyr Phe Glu Leu Leu Lys Gln Leu Glu Glu Lys Ser Glu Asp Gln Glu
        355                 360                 365             
Asp Lys Glu Cys Leu Lys Gln Ala Ile Thr Ala Leu Leu Asn Val Gln
    370                 375                 380                 
Ser Gly Met Glu Lys Ile Cys Ser Lys Ser Leu Ala Lys Arg Arg Leu
385                 390                 395                 400 
Ser Glu Ser Ala Cys Arg Phe Tyr Ser Gln Gln Met Lys Gly Lys Gln
                405                 410                 415     
Leu Ala Ile Lys Lys Met Asn Glu Ile Gln Lys Asn Ile Asp Gly Trp
            420                 425                 430         
Glu Gly Lys Asp Ile Gly Gln Cys Cys Asn Glu Phe Ile Met Glu Gly
        435                 440                 445             
Thr Leu Thr Arg Val Gly Ala Lys His Glu Arg His Ile Phe Leu Phe
    450                 455                 460                 
Asp Gly Leu Met Ile Cys Cys Lys Ser Asn His Gly Gln Pro Arg Leu
465                 470                 475                 480 
Pro Gly Ala Ser Asn Ala Glu Tyr Arg Leu Lys Glu Lys Phe Phe Met
                485                 490                 495     
Arg Lys Val Gln Ile Asn Asp Lys Asp Asp Thr Asn Glu Tyr Lys His
            500                 505                 510         
Ala Phe Glu Ile Ile Leu Lys Asp Glu Asn Ser Val Ile Phe Ser Ala
        515                 520                 525             
Lys Ser Ala Glu Glu Lys Asn Asn Trp Met Ala Ala Leu Ile Ser Leu
    530                 535                 540                 
Gln Tyr Arg Ser Thr Leu Glu Arg Met Leu Asp Val Thr Met Leu Gln
545                 550                 555                 560 
Glu Glu Lys Glu Glu Gln Met Arg Leu Pro Ser Ala Asp Val Tyr Arg
                565                 570                 575     
Phe Ala Glu Pro Asp Ser Glu Glu Asn Ile Ile Phe Glu Glu Asn Met
            580                 585                 590         
Gln Pro Lys Ala Gly Ile Pro Ile Ile Lys Ala Gly Thr Val Ile Lys
        595                 600                 605             
Leu Ile Glu Arg Leu Thr Tyr His Met Tyr Ala Asp Pro Asn Phe Val
    610                 615                 620                 
Arg Thr Phe Leu Thr Thr Tyr Arg Ser Phe Cys Lys Pro Gln Glu Leu
625                 630                 635                 640 
Leu Ser Leu Ile Ile Glu Arg Phe Glu Ile Pro Glu Pro Glu Pro Thr
                645                 650                 655     
Glu Ala Asp Arg Ile Ala Ile Glu Asn Gly Asp Gln Pro Leu Ser Ala
            660                 665                 670         
Glu Leu Lys Arg Phe Arg Lys Glu Tyr Ile Gln Pro Val Gln Leu Arg
        675                 680                 685             
Val Leu Asn Val Cys Arg His Trp Val Glu His His Phe Tyr Asp Phe
    690                 695                 700                 
Glu Arg Asp Ala Tyr Leu Leu Gln Arg Met Glu Glu Phe Ile Gly Thr
705                 710                 715                 720 
Val Arg Gly Lys Ala Met Lys Lys Trp Val Glu Ser Ile Thr Lys Ile
                725                 730                 735     
Ile Gln Arg Lys Lys Ile Ala Arg Asp Asn Gly Pro Gly His Asn Ile
            740                 745                 750         
Thr Phe Gln Ser Ser Pro Pro Thr Val Glu Trp His Ile Ser Arg Pro
        755                 760                 765             
Gly His Ile Glu Thr Phe Asp Leu Leu Thr Leu His Pro Ile Glu Ile
    770                 775                 780                 
Ala Arg Gln Leu Thr Leu Leu Glu Ser Asp Leu Tyr Arg Ala Val Gln
785                 790                 795                 800 
Pro Ser Glu Leu Val Gly Ser Val Trp Thr Lys Glu Asp Lys Glu Ile
                805                 810                 815     
Asn Ser Pro Asn Leu Leu Lys Met Ile Arg His Thr Thr Asn Leu Thr
            820                 825                 830         
Leu Trp Phe Glu Lys Cys Ile Val Glu Thr Glu Asn Leu Glu Glu Arg
        835                 840                 845             
Val Ala Val Val Ser Arg Ile Ile Glu Ile Leu Gln Val Phe Gln Glu
    850                 855                 860                 
Leu Asn Asn Phe Asn Gly Val Leu Glu Val Val Ser Ala Met Asn Ser
865                 870                 875                 880 
Ser Pro Val Tyr Arg Leu Asp His Thr Phe Glu Gln Ile Pro Ser Arg
                885                 890                 895     
Gln Lys Lys Ile Leu Glu Glu Ala His Glu Leu Ser Glu Asp His Tyr
            900                 905                 910         
Lys Lys Tyr Leu Ala Lys Leu Arg Ser Ile Asn Pro Pro Cys Val Pro
        915                 920                 925             
Phe Phe Gly Ile Tyr Leu Thr Asn Ile Leu Lys Thr Glu Glu Gly Asn
    930                 935                 940                 
Pro Glu Val Leu Lys Arg His Gly Lys Glu Leu Ile Asn Phe Ser Lys
945                 950                 955                 960 
Arg Arg Lys Val Ala Glu Ile Thr Gly Glu Ile Gln Gln Tyr Gln Asn
                965                 970                 975     
Gln Pro Tyr Cys Leu Arg Val Glu Ser Asp Ile Lys Arg Phe Phe Glu
            980                 985                 990         
Asn Leu Asn Pro Met Gly Asn Ser Met Glu Lys Glu Phe Thr Asp Tyr
        995                 1000                1005            
Leu Phe Asn Lys Ser Leu Glu Ile Glu Pro Arg Asn Pro Lys Pro Leu
    1010                1015                1020                
Pro Arg Phe Pro Lys Lys Tyr Ser Tyr Pro Leu Lys Ser Pro Gly Val
1025                1030                1035                1040
Arg Pro Ser Asn Pro Arg Pro Gly Thr Met Arg His Pro Thr Pro Leu
                1045                1050                1055    
Gln Gln Glu Pro Arg Lys Ile Ser Tyr Ser Arg Ile Pro Glu Ser Glu
            1060                1065                1070        
Thr Glu Ser Thr Ala Ser Ala Pro Asn Ser Pro Arg Thr Pro Leu Thr
        1075                1080                1085            
Pro Pro Pro Ala Ser Gly Ala Ser Ser Thr Thr Asp Val Cys Ser Val
    1090                1095                1100                
Phe Asp Ser Asp His Ser Ser Pro Phe His Ser Ser Asn Asp Thr Val
1105                1110                1115                1120
Phe Ile Gln Val Thr Leu Pro His Gly Pro Arg Ser Ala Ser Val Ser
                1125                1130                1135    
Ser Ile Ser Leu Thr Lys Gly Thr Asp Glu Val Pro Val Pro Pro Pro
            1140                1145                1150        
Val Pro Pro Arg Arg Arg Pro Glu Ser Ala Pro Ala Glu Ser Ser Pro
        1155                1160                1165            
Ser Lys Ile Met Ser Lys His Leu Asp Ser Pro Pro Ala Ile Pro Pro
    1170                1175                1180                
Arg Gln Pro Thr Ser Lys Ala Tyr Ser Pro Arg Tyr Ser Ile Ser Asp
1185                1190                1195                1200
Arg Thr Ser Ile Ser Asp Pro Pro Glu Ser Pro Pro Leu Leu Pro Pro
                1205                1210                1215    
Arg Glu Pro Val Arg Thr Pro Asp Val Phe Ser Ser Ser Pro Leu His
            1220                1225                1230        
Leu Gln Pro Pro Pro Leu Gly Lys Lys Ser Asp His Gly Asn Ala Phe
        1235                1240                1245            
Phe Pro Asn Ser Pro Ser Pro Phe Thr Pro Pro Pro Pro Gln Thr Pro
    1250                1255                1260                
Ser Pro His Gly Thr Arg Arg His Leu Pro Ser Pro Pro Leu Thr Gln
1265                1270                1275                1280
Glu Val Asp Leu His Ser Ile Ala Gly Pro Pro Val Pro Pro Arg Gln
                1285                1290                1295    
Ser Thr Ser Gln His Ile Pro Lys Leu Pro Pro Lys Thr Tyr Lys Arg
            1300                1305                1310        
Glu His Thr His Pro Ser Met His Arg Asp Gly Pro Pro Leu Leu Glu
        1315                1320                1325            
Asn Ala His Ser Ser
    1330            


<210> 2372
<211> 586
<212> PRT
<213> Homo sapiens

<400> 2372
Met Pro Lys Pro Ile Asn Val Arg Val Thr Thr Met Asp Ala Glu Leu
 1               5                  10                  15      
Glu Phe Ala Ile Gln Pro Asn Thr Thr Gly Lys Gln Leu Phe Asp Gln
            20                  25                  30          
Val Val Lys Thr Ile Gly Leu Arg Glu Val Trp Tyr Phe Gly Leu His
        35                  40                  45              
Tyr Val Asp Asn Lys Gly Phe Pro Thr Trp Leu Lys Leu Asp Lys Lys
    50                  55                  60                  
Val Ser Ala Gln Glu Val Arg Lys Glu Asn Pro Leu Gln Phe Lys Phe
65                  70                  75                  80  
Arg Ala Lys Phe Tyr Pro Glu Asp Val Ala Glu Glu Leu Ile Gln Asp
                85                  90                  95      
Ile Thr Gln Lys Leu Phe Phe Leu Gln Val Lys Glu Gly Ile Leu Ser
            100                 105                 110         
Asp Glu Ile Tyr Cys Pro Pro Glu Thr Ala Val Leu Leu Gly Ser Tyr
        115                 120                 125             
Ala Val Gln Ala Lys Phe Gly Asp Tyr Asn Lys Glu Val His Lys Ser
    130                 135                 140                 
Gly Tyr Leu Ser Ser Glu Arg Leu Ile Pro Gln Arg Val Met Asp Gln
145                 150                 155                 160 
His Lys Leu Thr Arg Asp Gln Trp Glu Asp Arg Ile Gln Val Trp His
                165                 170                 175     
Ala Glu His Arg Gly Met Leu Lys Asp Asn Ala Met Leu Glu Tyr Leu
            180                 185                 190         
Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Ile Asn Tyr Phe Glu Ile
        195                 200                 205             
Lys Asn Lys Lys Gly Thr Asp Leu Trp Leu Gly Val Asp Ala Leu Gly
    210                 215                 220                 
Leu Asn Ile Tyr Glu Lys Asp Asp Lys Leu Thr Pro Lys Ile Gly Phe
225                 230                 235                 240 
Pro Trp Ser Glu Ile Arg Asn Ile Ser Phe Asn Asp Lys Lys Phe Val
                245                 250                 255     
Ile Lys Pro Ile Asp Lys Lys Ala Pro Asp Phe Val Phe Tyr Ala Pro
            260                 265                 270         
Arg Leu Arg Ile Asn Lys Arg Ile Leu Gln Leu Cys Met Gly Asn His
        275                 280                 285             
Glu Leu Tyr Met Arg Arg Arg Lys Pro Asp Thr Ile Glu Val Gln Gln
    290                 295                 300                 
Met Lys Ala Gln Ala Arg Glu Glu Lys His Gln Lys Gln Leu Glu Arg
305                 310                 315                 320 
Gln Gln Leu Glu Thr Glu Lys Lys Arg Arg Glu Thr Val Glu Arg Glu
                325                 330                 335     
Lys Glu Gln Met Met Arg Glu Lys Glu Glu Leu Met Leu Arg Leu Gln
            340                 345                 350         
Asp Tyr Glu Glu Lys Thr Lys Lys Ala Glu Arg Glu Leu Ser Glu Gln
        355                 360                 365             
Ile Gln Arg Ala Leu Gln Leu Glu Glu Glu Arg Lys Arg Ala Gln Glu
    370                 375                 380                 
Glu Ala Glu Arg Leu Glu Ala Asp Arg Met Ala Ala Leu Arg Ala Lys
385                 390                 395                 400 
Glu Glu Leu Glu Arg Gln Ala Val Asp Gln Ile Lys Ser Gln Glu Gln
                405                 410                 415     
Leu Ala Ala Glu Leu Ala Glu Tyr Thr Ala Lys Ile Ala Leu Leu Glu
            420                 425                 430         
Glu Ala Arg Arg Arg Lys Glu Asp Glu Val Glu Glu Trp Gln His Arg
        435                 440                 445             
Ala Lys Glu Ala Gln Asp Asp Leu Val Lys Thr Lys Glu Glu Leu His
    450                 455                 460                 
Leu Val Met Thr Ala Pro Pro Pro Pro Pro Pro Pro Val Tyr Glu Pro
465                 470                 475                 480 
Val Ser Tyr His Val Gln Glu Ser Leu Gln Asp Glu Gly Ala Glu Pro
                485                 490                 495     
Thr Gly Tyr Ser Ala Glu Leu Ser Ser Glu Gly Ile Arg Asp Asp Arg
            500                 505                 510         
Asn Glu Glu Lys Arg Ile Thr Glu Ala Glu Lys Asn Glu Arg Val Gln
        515                 520                 525             
Arg Gln Leu Leu Thr Leu Ser Ser Glu Leu Ser Gln Ala Arg Asp Glu
    530                 535                 540                 
Asn Lys Arg Thr His Asn Asp Ile Ile His Asn Glu Asn Met Arg Gln
545                 550                 555                 560 
Gly Arg Asp Lys Tyr Lys Thr Leu Arg Gln Ile Arg Gln Gly Asn Thr
                565                 570                 575     
Lys Gln Arg Ile Asp Glu Phe Glu Ala Leu
            580                 585     


<210> 2373
<211> 237
<212> PRT
<213> Homo sapiens

<400> 2373
Met Ala Met Phe Arg Ser Leu Val Ala Ser Ala Gln Gln Arg Gln Pro
 1               5                  10                  15      
Pro Ala Gly Pro Ala Gly Gly Asp Ser Gly Leu Glu Ala Gln Tyr Thr
            20                  25                  30          
Cys Pro Ile Cys Leu Glu Val Tyr His Arg Pro Val Ala Ile Gly Ser
        35                  40                  45              
Cys Gly His Thr Phe Cys Gly Glu Cys Leu Gln Pro Cys Leu Gln Val
    50                  55                  60                  
Pro Ser Pro Leu Cys Pro Leu Cys Arg Leu Pro Phe Asp Pro Lys Lys
65                  70                  75                  80  
Val Asp Lys Ala Thr His Val Glu Lys Gln Leu Ser Ser Tyr Lys Ala
                85                  90                  95      
Pro Cys Arg Gly Cys Asn Lys Lys Val Thr Leu Ala Lys Met Arg Val
            100                 105                 110         
His Ile Ser Ser Cys Leu Lys Val Gln Glu Gln Met Ala Asn Cys Pro
        115                 120                 125             
Lys Phe Val Pro Val Val Pro Thr Ser Gln Pro Ile Pro Ser Asn Ile
    130                 135                 140                 
Pro Asn Arg Ser Thr Phe Ala Cys Pro Tyr Cys Gly Ala Arg Asn Leu
145                 150                 155                 160 
Asp Gln Gln Glu Leu Val Lys His Cys Val Glu Ser His Arg Ser Asp
                165                 170                 175     
Pro Asn Arg Val Val Cys Pro Ile Cys Ser Ala Met Pro Trp Gly Asp
            180                 185                 190         
Pro Ser Tyr Lys Ser Ala Asn Phe Leu Gln His Leu Leu His Arg His
        195                 200                 205             
Lys Phe Ser Tyr Asp Thr Phe Val Asp Tyr Ser Ile Asp Glu Glu Ala
    210                 215                 220                 
Ala Phe Gln Ala Ala Leu Ala Leu Ser Leu Ser Glu Asn
225                 230                 235         


<210> 2374
<211> 917
<212> PRT
<213> Homo sapiens

<400> 2374
Met Ile Ala Ser His Leu Leu Ala Tyr Phe Phe Thr Glu Leu Asn His
 1               5                  10                  15      
Asp Gln Val Gln Lys Val Asp Gln Tyr Leu Tyr His Met Arg Leu Ser
            20                  25                  30          
Asp Glu Thr Leu Leu Glu Ile Ser Lys Arg Phe Arg Lys Glu Met Glu
        35                  40                  45              
Lys Gly Leu Gly Ala Thr Thr His Pro Thr Ala Ala Val Lys Met Leu
    50                  55                  60                  
Pro Thr Phe Val Arg Ser Thr Pro Asp Gly Thr Glu His Gly Glu Phe
65                  70                  75                  80  
Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val Leu Trp Val Lys
                85                  90                  95      
Val Thr Asp Asn Gly Leu Gln Lys Val Glu Met Glu Asn Gln Ile Tyr
            100                 105                 110         
Ala Ile Pro Glu Asp Ile Met Arg Gly Ser Gly Thr Gln Leu Phe Asp
        115                 120                 125             
His Ile Ala Glu Cys Leu Ala Asn Phe Met Asp Lys Leu Gln Ile Lys
    130                 135                 140                 
Asp Lys Lys Leu Pro Leu Gly Phe Thr Phe Ser Phe Pro Cys His Gln
145                 150                 155                 160 
Thr Lys Leu Asp Glu Ser Phe Leu Val Ser Trp Thr Lys Gly Phe Lys
                165                 170                 175     
Ser Ser Gly Val Glu Gly Arg Asp Val Val Ala Leu Ile Arg Lys Ala
            180                 185                 190         
Ile Gln Arg Arg Gly Asp Phe Asp Ile Asp Ile Val Ala Val Val Asn
        195                 200                 205             
Asp Thr Val Gly Thr Met Met Thr Cys Gly Tyr Asp Asp His Asn Cys
    210                 215                 220                 
Glu Ile Gly Leu Ile Val Gly Thr Gly Ser Asn Ala Cys Tyr Met Glu
225                 230                 235                 240 
Glu Met Arg His Ile Asp Met Val Glu Gly Asp Glu Gly Arg Met Cys
                245                 250                 255     
Ile Asn Met Glu Trp Gly Ala Phe Gly Asp Asp Gly Ser Leu Asn Asp
            260                 265                 270         
Ile Arg Thr Glu Phe Asp Gln Glu Ile Asp Met Gly Ser Leu Asn Pro
        275                 280                 285             
Gly Lys Gln Leu Phe Glu Lys Met Ile Ser Gly Met Tyr Met Gly Glu
    290                 295                 300                 
Leu Val Arg Leu Ile Leu Val Lys Met Ala Lys Glu Glu Leu Leu Phe
305                 310                 315                 320 
Gly Gly Lys Leu Ser Pro Glu Leu Leu Asn Thr Gly Arg Phe Glu Thr
                325                 330                 335     
Lys Asp Ile Ser Asp Ile Glu Gly Glu Lys Asp Gly Ile Arg Lys Ala
            340                 345                 350         
Arg Glu Val Leu Met Arg Leu Gly Leu Asp Pro Thr Gln Glu Asp Cys
        355                 360                 365             
Val Ala Thr His Arg Ile Cys Gln Ile Val Ser Thr Arg Ser Ala Ser
    370                 375                 380                 
Leu Cys Ala Ala Thr Leu Ala Ala Val Leu Gln Arg Ile Lys Glu Asn
385                 390                 395                 400 
Lys Gly Glu Glu Arg Leu Arg Ser Thr Ile Gly Val Asp Gly Ser Val
                405                 410                 415     
Tyr Lys Lys His Pro His Phe Ala Lys Arg Leu His Lys Thr Val Arg
            420                 425                 430         
Arg Leu Val Pro Gly Cys Asp Val Arg Phe Leu Arg Ser Glu Asp Gly
        435                 440                 445             
Ser Gly Lys Gly Ala Ala Met Val Thr Ala Val Ala Tyr Arg Leu Ala
    450                 455                 460                 
Asp Gln His Arg Ala Arg Gln Lys Thr Leu Glu His Leu Gln Leu Ser
465                 470                 475                 480 
His Asp Gln Leu Leu Glu Val Lys Arg Arg Met Lys Val Glu Met Glu
                485                 490                 495     
Arg Gly Leu Ser Lys Glu Thr His Ala Ser Ala Pro Val Lys Met Leu
            500                 505                 510         
Pro Thr Tyr Val Cys Ala Thr Pro Asp Gly Thr Glu Lys Gly Asp Phe
        515                 520                 525             
Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val Leu Leu Val Arg
    530                 535                 540                 
Val Arg Asn Gly Lys Trp Gly Gly Val Glu Met His Asn Lys Ile Tyr
545                 550                 555                 560 
Ala Ile Pro Gln Glu Val Met His Gly Thr Gly Asp Glu Leu Phe Asp
                565                 570                 575     
His Ile Val Gln Cys Ile Ala Asp Phe Leu Glu Tyr Met Gly Met Lys
            580                 585                 590         
Gly Val Ser Leu Pro Leu Gly Phe Thr Phe Ser Phe Pro Cys Gln Gln
        595                 600                 605             
Asn Ser Leu Asp Glu Ser Ile Leu Leu Lys Trp Thr Lys Gly Phe Lys
    610                 615                 620                 
Ala Ser Gly Cys Glu Gly Glu Asp Val Val Thr Leu Leu Lys Glu Ala
625                 630                 635                 640 
Ile His Arg Arg Glu Glu Phe Asp Leu Asp Val Val Ala Val Val Asn
                645                 650                 655     
Asp Thr Val Gly Thr Met Met Thr Cys Gly Phe Glu Asp Pro His Cys
            660                 665                 670         
Glu Val Gly Leu Ile Val Gly Thr Gly Ser Asn Ala Cys Tyr Met Glu
        675                 680                 685             
Glu Met Arg Asn Val Glu Leu Val Glu Gly Glu Glu Gly Arg Met Cys
    690                 695                 700                 
Val Asn Met Glu Trp Gly Ala Phe Gly Asp Asn Gly Cys Leu Asp Asp
705                 710                 715                 720 
Phe Arg Thr Glu Phe Asp Val Ala Val Asp Glu Leu Ser Leu Asn Pro
                725                 730                 735     
Gly Lys Gln Arg Phe Glu Lys Met Ile Ser Gly Met Tyr Leu Gly Glu
            740                 745                 750         
Ile Val Arg Asn Ile Leu Ile Asp Phe Thr Lys Arg Gly Leu Leu Phe
        755                 760                 765             
Arg Gly Arg Ile Ser Glu Arg Leu Lys Thr Arg Gly Ile Phe Glu Thr
    770                 775                 780                 
Lys Phe Leu Ser Gln Ile Glu Ser Asp Cys Leu Ala Leu Leu Gln Val
785                 790                 795                 800 
Arg Ala Ile Leu Gln His Leu Gly Leu Glu Ser Thr Cys Asp Asp Ser
                805                 810                 815     
Ile Ile Val Lys Glu Val Cys Thr Val Val Ala Arg Arg Ala Ala Gln
            820                 825                 830         
Leu Cys Gly Ala Gly Met Ala Ala Val Val Asp Arg Ile Arg Glu Asn
        835                 840                 845             
Arg Gly Leu Asp Ala Leu Lys Val Thr Val Gly Val Asp Gly Thr Leu
    850                 855                 860                 
Tyr Lys Leu His Pro His Phe Ala Lys Val Met His Glu Thr Val Lys
865                 870                 875                 880 
Asp Leu Ala Pro Lys Cys Asp Val Ser Phe Leu Gln Ser Glu Asp Gly
                885                 890                 895     
Ser Gly Lys Gly Ala Ala Leu Ile Thr Ala Val Ala Cys Arg Ile Arg
            900                 905                 910         
Glu Ala Gly Gln Arg
        915         


<210> 2375
<211> 115
<212> PRT
<213> Homo sapiens

<400> 2375
Met Pro Arg Arg Arg Arg Arg Arg Gly Ser Ser Gly Ala Gly Gly Arg
 1               5                  10                  15      
Gly Arg Thr Cys Ser Arg Thr Val Arg Ala Glu Leu Ser Phe Ser Val
            20                  25                  30          
Ser Gln Val Glu Arg Ser Leu Arg Glu Gly His Tyr Ala Gln Arg Leu
        35                  40                  45              
Ser Arg Thr Ala Pro Val Tyr Leu Ala Ala Val Ile Glu Tyr Leu Thr
    50                  55                  60                  
Ala Lys Val Leu Glu Leu Ala Gly Asn Glu Ala Gln Asn Ser Gly Glu
65                  70                  75                  80  
Arg Asn Ile Thr Pro Leu Leu Leu Asp Met Val Val His Asn Asp Arg
                85                  90                  95      
Leu Leu Ser Thr Leu Phe Asn Thr Thr Thr Ile Ser Gln Val Ala Pro
            100                 105                 110         
Gly Glu Asp
        115 


<210> 2376
<211> 432
<212> PRT
<213> Homo sapiens

<400> 2376
Met Glu Gly Leu Ala Val Arg Leu Leu Arg Gly Ser Lys Leu Leu Arg
 1               5                  10                  15      
Arg Asn Phe Leu Thr Cys Leu Ser Ser Trp Lys Ile Pro Pro His Val
            20                  25                  30          
Ser Lys Ser Ser Gln Ser Glu Ala Leu Leu Asn Ile Thr Asn Asn Gly
        35                  40                  45              
Ile His Phe Ala Pro Leu Gln Thr Phe Thr Asp Glu Glu Met Met Ile
    50                  55                  60                  
Lys Ser Ser Val Lys Lys Phe Ala Gln Glu Gln Ile Ala Pro Leu Val
65                  70                  75                  80  
Ser Thr Met Asp Glu Asn Ser Lys Met Glu Lys Ser Val Ile Gln Gly
                85                  90                  95      
Leu Phe Gln Gln Gly Leu Met Gly Ile Glu Val Asp Pro Glu Tyr Gly
            100                 105                 110         
Gly Thr Gly Ala Ser Phe Leu Ser Thr Val Leu Val Ile Glu Glu Leu
        115                 120                 125             
Ala Lys Val Asp Ala Ser Val Ala Val Phe Cys Glu Ile Gln Asn Thr
    130                 135                 140                 
Leu Ile Asn Thr Leu Ile Arg Lys His Gly Thr Glu Glu Gln Lys Ala
145                 150                 155                 160 
Thr Tyr Leu Pro Gln Leu Thr Thr Glu Lys Val Gly Ser Phe Cys Leu
                165                 170                 175     
Ser Glu Ala Gly Ala Gly Ser Asp Ser Phe Ala Leu Lys Thr Arg Ala
            180                 185                 190         
Asp Lys Glu Gly Asp Tyr Tyr Val Leu Asn Gly Ser Lys Met Trp Ile
        195                 200                 205             
Ser Ser Ala Glu His Ala Gly Leu Phe Leu Val Met Ala Asn Val Asp
    210                 215                 220                 
Pro Thr Ile Gly Tyr Lys Gly Ile Thr Ser Phe Leu Val Asp Arg Asp
225                 230                 235                 240 
Thr Pro Gly Leu His Ile Gly Lys Pro Glu Asn Lys Leu Gly Leu Arg
                245                 250                 255     
Ala Ser Ser Thr Cys Pro Leu Thr Phe Glu Asn Val Lys Val Pro Glu
            260                 265                 270         
Ala Asn Ile Leu Gly Gln Ile Gly His Gly Tyr Lys Tyr Ala Ile Gly
        275                 280                 285             
Ser Leu Asn Glu Gly Arg Ile Gly Ile Ala Ala Gln Met Leu Gly Leu
    290                 295                 300                 
Ala Gln Gly Cys Phe Asp Tyr Thr Ile Pro Tyr Ile Lys Glu Arg Ile
305                 310                 315                 320 
Gln Phe Gly Lys Arg Leu Phe Asp Phe Gln Gly Leu Gln His Gln Val
                325                 330                 335     
Ala His Val Ala Thr Gln Leu Glu Ala Ala Arg Leu Leu Thr Tyr Asn
            340                 345                 350         
Ala Ala Arg Leu Leu Glu Ala Gly Lys Pro Phe Ile Lys Glu Ala Ser
        355                 360                 365             
Met Ala Lys Tyr Tyr Ala Ser Glu Ile Ala Gly Gln Thr Thr Ser Lys
    370                 375                 380                 
Cys Ile Glu Trp Met Gly Gly Val Gly Tyr Thr Lys Asp Tyr Pro Val
385                 390                 395                 400 
Glu Lys Tyr Phe Arg Asp Ala Lys Ile Gly Thr Ile Tyr Glu Gly Ala
                405                 410                 415     
Ser Asn Ile Gln Leu Asn Thr Ile Ala Lys His Ile Asp Ala Glu Tyr
            420                 425                 430         


<210> 2377
<211> 213
<212> PRT
<213> Homo sapiens

<400> 2377
Gly Thr Arg Leu Pro Ala Glu Arg Leu Gln Leu Gly Asp Leu Pro His
 1               5                  10                  15      
Gly Arg Ser Pro Ala Gly Gln Gly Asn Arg Arg Gly Gly Gly Leu Leu
            20                  25                  30          
Val Arg Pro Ser Pro Pro Asn Ser Gly Pro Leu Ala Ala Pro Gly Asp
        35                  40                  45              
His Arg Val Arg Pro Ser Pro Gly Arg Ala Gln Ser Trp Thr Pro Pro
    50                  55                  60                  
Pro Ser Val Thr Ala Cys Ile Phe Ser Pro Phe Pro Ser Gln Pro Ala
65                  70                  75                  80  
Glu Arg Arg Gln Pro Gln Ser Arg Cys Leu His Pro Leu Leu Met Pro
                85                  90                  95      
Ala Val Phe Met Leu Ala Ser Ser Ser Ala Leu Gln Cys Gly Arg Gly
            100                 105                 110         
Val Pro Arg Phe Pro Arg Thr Glu Val Gly Ala Gly His Ser Val Asn
        115                 120                 125             
Glu Glu Thr Lys Ala Glu Lys Val Gly Asn Gln Thr Ser Val Ile Pro
    130                 135                 140                 
Ala Thr Ser Arg Gln Ala Ala Leu Gly Thr Ser Trp Thr Gln Arg Arg
145                 150                 155                 160 
Thr Gln Pro Leu Gln Glu Arg Ser His Trp His Pro Arg Gly Asn Asn
                165                 170                 175     
Ala Ser Gly Met Gly Gly His Arg Met Phe Pro Gly Pro Leu Arg Gly
            180                 185                 190         
Pro Ala Ala Gln Val Leu Glu Asn Glu Cys Gly Ser Leu Gly Arg Ala
        195                 200                 205             
Ala Glu Gly Arg Ser
    210             


<210> 2378
<211> 615
<212> PRT
<213> Homo sapiens

<400> 2378
Met Ala Val Tyr Val Gly Met Leu Arg Leu Gly Arg Leu Cys Ala Gly
 1               5                  10                  15      
Ser Ser Gly Val Leu Gly Ala Arg Ala Ala Leu Ser Arg Ser Trp Gln
            20                  25                  30          
Glu Ala Arg Leu Gln Gly Val Arg Phe Leu Ser Ser Arg Glu Val Asp
        35                  40                  45              
Arg Met Val Ser Thr Pro Ile Gly Gly Leu Ser Tyr Val Gln Gly Cys
    50                  55                  60                  
Thr Lys Lys His Leu Asn Ser Lys Thr Val Val Gln Cys Leu Glu Thr
65                  70                  75                  80  
Thr Ala Gln Arg Val Pro Glu Arg Glu Ala Leu Val Val Leu His Glu
                85                  90                  95      
Asp Val Arg Leu Thr Phe Ala Gln Leu Lys Glu Glu Val Asp Lys Ala
            100                 105                 110         
Ala Ser Gly Leu Leu Ser Ile Gly Leu Cys Lys Gly Asp Arg Leu Gly
        115                 120                 125             
Met Trp Gly Pro Asn Ser Tyr Ala Trp Val Leu Met Gln Leu Ala Thr
    130                 135                 140                 
Ala Gln Ala Gly Ile Ile Leu Val Ser Val Asn Pro Ala Tyr Gln Ala
145                 150                 155                 160 
Met Glu Leu Glu Tyr Val Leu Lys Lys Val Gly Cys Lys Ala Leu Val
                165                 170                 175     
Phe Pro Lys Gln Phe Lys Thr Gln Gln Tyr Tyr Asn Val Leu Lys Gln
            180                 185                 190         
Ile Cys Pro Glu Val Glu Asn Ala Gln Pro Gly Ala Leu Lys Ser Gln
        195                 200                 205             
Arg Leu Pro Asp Leu Thr Thr Val Ile Ser Val Asp Ala Pro Leu Pro
    210                 215                 220                 
Gly Thr Leu Leu Leu Asp Glu Val Val Ala Ala Gly Ser Thr Arg Gln
225                 230                 235                 240 
His Leu Asp Gln Leu Gln Tyr Asn Gln Gln Phe Leu Ser Cys His Asp
                245                 250                 255     
Pro Ile Asn Ile Gln Phe Thr Ser Gly Thr Thr Gly Ser Pro Lys Gly
            260                 265                 270         
Ala Thr Leu Ser His Tyr Asn Ile Val Asn Asn Ser Asn Ile Leu Gly
        275                 280                 285             
Glu Arg Leu Lys Leu His Glu Lys Thr Pro Glu Gln Leu Arg Met Ile
    290                 295                 300                 
Leu Pro Asn Pro Leu Tyr His Cys Leu Gly Ser Val Ala Gly Thr Met
305                 310                 315                 320 
Met Cys Leu Met Tyr Gly Ala Thr Leu Ile Leu Ala Ser Pro Ile Phe
                325                 330                 335     
Asn Gly Lys Lys Ala Leu Glu Ala Ile Ser Arg Glu Arg Gly Thr Phe
            340                 345                 350         
Leu Tyr Gly Thr Pro Thr Met Phe Val Asp Ile Leu Asn Gln Pro Asp
        355                 360                 365             
Phe Ser Ser Tyr Asp Ile Ser Thr Met Cys Gly Gly Val Ile Ala Gly
    370                 375                 380                 
Ser Pro Ala Pro Pro Glu Leu Ile Arg Ala Ile Ile Asn Lys Ile Asn
385                 390                 395                 400 
Met Lys Asp Leu Val Val Ala Tyr Gly Thr Thr Glu Asn Ser Pro Val
                405                 410                 415     
Thr Phe Ala His Phe Pro Glu Asp Thr Val Glu Gln Lys Ala Glu Ser
            420                 425                 430         
Val Gly Arg Ile Met Pro His Thr Glu Ala Arg Ile Met Asn Met Glu
        435                 440                 445             
Ala Gly Thr Leu Ala Lys Leu Asn Thr Pro Gly Glu Leu Cys Ile Arg
    450                 455                 460                 
Gly Tyr Cys Val Met Leu Gly Tyr Trp Gly Glu Pro Gln Lys Thr Glu
465                 470                 475                 480 
Glu Ala Val Asp Gln Asp Lys Trp Tyr Trp Thr Gly Asp Val Ala Thr
                485                 490                 495     
Met Asn Glu Gln Gly Phe Cys Lys Ile Val Gly Arg Ser Lys Asp Met
            500                 505                 510         
Ile Ile Arg Gly Gly Glu Asn Ile Tyr Pro Ala Glu Leu Glu Asp Phe
        515                 520                 525             
Phe His Thr His Pro Lys Val Gln Glu Val Gln Val Val Gly Val Lys
    530                 535                 540                 
Asp Asp Arg Met Gly Glu Glu Ile Cys Ala Cys Ile Arg Leu Lys Asp
545                 550                 555                 560 
Gly Glu Glu Thr Thr Val Glu Glu Ile Lys Ala Phe Cys Lys Gly Lys
                565                 570                 575     
Ile Ser His Phe Lys Ile Pro Lys Tyr Ile Val Phe Val Thr Asn Tyr
            580                 585                 590         
Pro Leu Thr Ile Ser Gly Lys Ile Gln Lys Phe Lys Leu Arg Glu Gln
        595                 600                 605             
Met Glu Arg His Leu Asn Leu
    610                 615 


<210> 2379
<211> 393
<212> PRT
<213> Homo sapiens

<400> 2379
Ala Arg Gly Glu Glu Glu Pro Val Ala Pro Ser Thr Val Ala Pro Arg
 1               5                  10                  15      
Trp Leu Glu Glu Glu Ala Ala Leu Gln Leu Ala Leu His Arg Ser Leu
            20                  25                  30          
Glu Pro Gln Gly Gln Val Ala Glu Gln Glu Glu Ala Ala Ala Leu Arg
        35                  40                  45              
Gln Ala Leu Thr Leu Ser Leu Leu Glu Gln Pro Pro Leu Glu Ala Glu
    50                  55                  60                  
Glu Pro Pro Asp Gly Gly Thr Asp Gly Lys Ala Gln Leu Val Val His
65                  70                  75                  80  
Ser Ala Phe Glu Gln Asp Val Glu Glu Leu Asp Arg Ala Leu Arg Ala
                85                  90                  95      
Ala Leu Glu Val His Val Gln Glu Glu Thr Val Gly Pro Trp Arg Arg
            100                 105                 110         
Thr Leu Pro Ala Glu Leu Arg Ala Arg Leu Glu Arg Cys His Gly Val
        115                 120                 125             
Ser Val Ala Leu Arg Gly Asp Cys Thr Ile Leu Arg Gly Phe Gly Ala
    130                 135                 140                 
His Pro Ala Arg Ala Ala Arg His Leu Val Ala Leu Leu Ala Gly Pro
145                 150                 155                 160 
Trp Asp Gln Ser Leu Ala Phe Pro Leu Ala Ala Ser Gly Pro Thr Leu
                165                 170                 175     
Ala Gly Gln Thr Pro Lys Gly Pro Trp Asn Asn Leu Glu Arg Leu Ala
            180                 185                 190         
Glu Asn Thr Gly Glu Phe Gln Glu Val Val Arg Ala Phe Tyr Asp Thr
        195                 200                 205             
Leu Asp Ala Ala Arg Ser Ser Ile Arg Val Val Arg Val Glu Arg Val
    210                 215                 220                 
Ser His Pro Leu Leu Gln Gln Gln Tyr Glu Leu Tyr Arg Glu Arg Leu
225                 230                 235                 240 
Leu Gln Arg Cys Glu Arg Arg Pro Val Glu Gln Val Leu Tyr His Gly
                245                 250                 255     
Thr Thr Ala Pro Ala Val Pro Asp Ile Cys Ala His Gly Phe Asn Arg
            260                 265                 270         
Ser Phe Cys Gly Arg Asn Ala Thr Val Tyr Gly Lys Gly Val Tyr Phe
        275                 280                 285             
Ala Arg Arg Ala Ser Leu Ser Val Gln Asp Arg Tyr Ser Pro Pro Asn
    290                 295                 300                 
Ala Asp Gly His Lys Ala Val Phe Val Ala Arg Val Leu Thr Gly Asp
305                 310                 315                 320 
Tyr Gly Gln Gly Arg Arg Gly Leu Arg Ala Pro Pro Leu Arg Gly Pro
                325                 330                 335     
Gly His Val Leu Leu Arg Tyr Asp Ser Ala Val Asp Cys Ile Cys Gln
            340                 345                 350         
Pro Ser Ile Phe Val Ile Phe His Asp Thr Gln Ala Leu Pro Thr His
        355                 360                 365             
Leu Ile Thr Cys Glu His Val Pro Arg Ala Ser Pro Asp Asp Pro Ser
    370                 375                 380                 
Gly Leu Pro Gly Arg Ser Pro Asp Thr
385                 390             


<210> 2380
<211> 1348
<212> PRT
<213> Homo sapiens

<400> 2380
Gly Ala Lys Asp Leu Val Cys Ser Lys Met Ser Arg Ala Lys Asp Ala
 1               5                  10                  15      
Val Ser Ser Gly Val Ala Ser Val Val Asp Val Ala Lys Gly Val Val
            20                  25                  30          
Gln Gly Gly Leu Asp Thr Thr Arg Ser Ala Leu Thr Gly Thr Lys Glu
        35                  40                  45              
Ala Val Ser Ser Gly Val Thr Gly Ala Met Asp Met Ala Lys Gly Ala
    50                  55                  60                  
Val Gln Gly Gly Leu Asp Thr Ser Lys Ala Val Leu Thr Gly Thr Lys
65                  70                  75                  80  
Asp Thr Val Ser Thr Gly Leu Thr Gly Ala Val Asn Val Ala Lys Gly
                85                  90                  95      
Thr Val Gln Ala Gly Val Asp Thr Thr Lys Thr Val Leu Thr Gly Thr
            100                 105                 110         
Lys Asp Thr Val Thr Thr Gly Val Met Gly Ala Val Asn Leu Ala Lys
        115                 120                 125             
Gly Thr Val Gln Thr Gly Val Glu Thr Ser Lys Ala Val Leu Thr Gly
    130                 135                 140                 
Thr Lys Asp Ala Val Ser Thr Gly Leu Thr Gly Ala Val Asn Val Ala
145                 150                 155                 160 
Arg Gly Ser Ile Gln Thr Gly Val Asp Thr Ser Lys Thr Val Leu Thr
                165                 170                 175     
Gly Thr Lys Asp Thr Val Cys Ser Gly Val Thr Ser Ala Met Asn Val
            180                 185                 190         
Ala Lys Gly Thr Ile Gln Thr Gly Val Asp Thr Ser Lys Thr Val Leu
        195                 200                 205             
Thr Gly Thr Lys Asp Thr Val Cys Ser Gly Val Thr Gly Ala Met Asn
    210                 215                 220                 
Val Ala Lys Gly Thr Ile Gln Thr Gly Val Asp Thr Ser Lys Thr Val
225                 230                 235                 240 
Leu Thr Gly Thr Lys Asp Thr Val Cys Ser Gly Val Thr Gly Ala Met
                245                 250                 255     
Asn Val Ala Lys Gly Thr Ile Gln Thr Gly Val Asp Thr Thr Lys Thr
            260                 265                 270         
Val Leu Thr Gly Thr Lys Asn Thr Val Cys Ser Gly Val Thr Gly Ala
        275                 280                 285             
Val Asn Leu Ala Lys Glu Ala Ile Gln Gly Gly Leu Asp Thr Thr Lys
    290                 295                 300                 
Ser Met Val Met Gly Thr Lys Asp Thr Met Ser Thr Gly Leu Thr Gly
305                 310                 315                 320 
Ala Ala Asn Val Ala Lys Gly Ala Met Gln Thr Gly Leu Asn Thr Thr
                325                 330                 335     
Gln Asn Ile Ala Thr Gly Thr Lys Asp Thr Val Cys Ser Gly Val Thr
            340                 345                 350         
Gly Ala Met Asn Leu Ala Arg Gly Thr Ile Gln Thr Gly Val Asp Thr
        355                 360                 365             
Thr Lys Ile Val Leu Thr Gly Thr Lys Asp Thr Val Cys Ser Gly Val
    370                 375                 380                 
Thr Gly Ala Ala Asn Val Ala Lys Gly Ala Val Gln Gly Gly Leu Asp
385                 390                 395                 400 
Thr Thr Lys Ser Val Leu Thr Gly Thr Lys Asp Ala Val Ser Thr Gly
                405                 410                 415     
Leu Thr Gly Ala Val Asn Val Ala Lys Gly Thr Val Gln Thr Gly Val
            420                 425                 430         
Asp Thr Thr Lys Thr Val Leu Thr Gly Thr Lys Asp Thr Val Cys Ser
        435                 440                 445             
Gly Val Thr Ser Ala Val Asn Val Ala Lys Gly Ala Val Gln Gly Gly
    450                 455                 460                 
Leu Asp Thr Thr Lys Ser Val Val Ile Gly Thr Lys Asp Thr Met Ser
465                 470                 475                 480 
Thr Gly Leu Thr Gly Ala Ala Asn Val Ala Lys Gly Ala Val Gln Thr
                485                 490                 495     
Gly Val Asp Thr Ala Lys Thr Val Leu Thr Gly Thr Lys Asp Thr Val
            500                 505                 510         
Thr Thr Gly Leu Val Gly Ala Val Asn Val Ala Lys Gly Thr Val Gln
        515                 520                 525             
Thr Gly Met Asp Thr Thr Lys Thr Val Leu Thr Gly Thr Lys Asp Thr
    530                 535                 540                 
Ile Tyr Ser Gly Val Thr Ser Ala Val Asn Val Ala Lys Gly Ala Val
545                 550                 555                 560 
Gln Thr Gly Leu Lys Thr Thr Gln Asn Ile Ala Thr Gly Thr Lys Asn
                565                 570                 575     
Thr Phe Gly Ser Gly Val Thr Gly Ala Val Asn Val Ala Lys Gly Ala
            580                 585                 590         
Val Gln Thr Gly Val Asp Thr Ala Lys Thr Val Leu Thr Gly Thr Lys
        595                 600                 605             
Asp Thr Val Thr Thr Gly Leu Met Gly Ala Val Asn Val Ala Lys Gly
    610                 615                 620                 
Thr Val Gln Thr Ser Val Asp Thr Thr Lys Thr Val Leu Thr Gly Thr
625                 630                 635                 640 
Lys Asp Thr Val Cys Ser Gly Val Thr Gly Ala Ala Asn Val Ala Lys
                645                 650                 655     
Gly Ala Val Gln Thr Gly Val Asp Thr Ala Lys Thr Val Leu Thr Gly
            660                 665                 670         
Thr Lys Asp Thr Val Cys Ser Gly Val Thr Gly Ala Val Asn Val Ala
        675                 680                 685             
Lys Gly Ala Val Gln Thr Gly Leu Lys Thr Thr Gln Asn Ile Ala Thr
    690                 695                 700                 
Gly Thr Lys Asn Thr Leu Gly Ser Gly Val Thr Gly Ala Ala Asn Val
705                 710                 715                 720 
Ala Lys Gly Ala Val Gln Gly Gly Leu Asp Thr Thr Lys Ser Val Leu
                725                 730                 735     
Thr Gly Thr Lys Asp Ala Val Ser Thr Gly Leu Thr Gly Ala Val Asn
            740                 745                 750         
Leu Ala Lys Gly Thr Val Gln Thr Gly Met Asp Thr Thr Lys Thr Val
        755                 760                 765             
Leu Thr Gly Thr Lys Asp Ala Val Cys Ser Gly Val Thr Gly Ala Ala
    770                 775                 780                 
Asn Val Ala Lys Gly Ala Val Gln Thr Gly Val Asp Thr Ala Lys Thr
785                 790                 795                 800 
Val Leu Thr Gly Thr Lys Asp Thr Val Thr Thr Gly Leu Met Gly Ala
                805                 810                 815     
Val Asn Val Ala Lys Gly Thr Val Gln Thr Ser Val Asp Thr Thr Lys
            820                 825                 830         
Thr Val Leu Thr Gly Thr Lys Asp Thr Val Cys Ser Gly Val Thr Gly
        835                 840                 845             
Ala Ala Asn Val Ala Lys Gly Ala Val Gln Gly Gly Leu Asp Thr Thr
    850                 855                 860                 
Lys Ser Val Leu Thr Gly Thr Lys Asp Thr Val Ser Thr Gly Leu Thr
865                 870                 875                 880 
Gly Ala Val Asn Leu Ala Lys Gly Thr Val Gln Thr Gly Val Asp Thr
                885                 890                 895     
Ser Lys Thr Val Leu Thr Gly Thr Lys Asp Thr Val Cys Ser Gly Val
            900                 905                 910         
Thr Gly Ala Val Asn Val Ala Lys Gly Thr Val Gln Thr Gly Val Asp
        915                 920                 925             
Thr Ala Lys Thr Val Leu Ser Gly Ala Lys Asp Ala Val Thr Thr Gly
    930                 935                 940                 
Val Thr Gly Ala Val Asn Val Ala Lys Gly Thr Val Gln Thr Gly Val
945                 950                 955                 960 
Asp Ala Ser Lys Ala Val Leu Met Gly Thr Lys Asp Thr Val Phe Ser
                965                 970                 975     
Gly Val Thr Gly Ala Met Ser Met Ala Lys Gly Ala Val Gln Gly Gly
            980                 985                 990         
Leu Asp Thr Thr Lys Thr Val Leu Thr Gly Thr Lys Asp Ala Val Ser
        995                 1000                1005            
Ala Gly Leu Met Gly Ser Gly Asn Val Ala Thr Gly Ala Thr His Thr
    1010                1015                1020                
Gly Leu Ser Thr Phe Gln Asn Trp Leu Pro Ser Thr Pro Ala Thr Ser
1025                1030                1035                1040
Trp Gly Gly Leu Thr Ser Ser Arg Thr Thr Asp Asn Gly Gly Glu Gln
                1045                1050                1055    
Thr Ala Leu Ser Pro Gln Glu Ala Pro Phe Ser Gly Ile Ser Thr Pro
            1060                1065                1070        
Pro Asp Val Leu Ser Val Gly Pro Glu Pro Ala Trp Glu Ala Ala Ala
        1075                1080                1085            
Thr Thr Lys Gly Leu Ala Thr Asp Val Ala Thr Phe Thr Gln Gly Ala
    1090                1095                1100                
Ala Pro Gly Arg Glu Asp Thr Gly Leu Leu Thr Thr Thr His Gly Pro
1105                1110                1115                1120
Glu Glu Ala Pro Arg Leu Ala Met Leu Gln Asn Glu Leu Glu Gly Leu
                1125                1130                1135    
Gly Asp Ile Phe His Pro Met Asn Ala Glu Glu Gln Ala Gln Leu Ala
            1140                1145                1150        
Ala Ser Gln Pro Gly Pro Lys Val Leu Ser Ala Glu Gln Gly Ser Tyr
        1155                1160                1165            
Phe Val Arg Leu Gly Asp Leu Gly Pro Ser Phe Arg Gln Arg Ala Phe
    1170                1175                1180                
Glu His Ala Val Ser His Leu Gln His Gly Gln Phe Gln Ala Arg Asp
1185                1190                1195                1200
Thr Leu Ala Gln Leu Gln Asp Cys Phe Arg Leu Ile Glu Lys Ala Gln
                1205                1210                1215    
Gln Ala Pro Glu Gly Gln Pro Arg Leu Asp Gln Gly Ser Gly Ala Ser
            1220                1225                1230        
Ala Glu Asp Ala Ala Val Gln Glu Glu Arg Asp Ala Gly Val Leu Ser
        1235                1240                1245            
Arg Val Cys Gly Leu Leu Arg Gln Leu His Thr Ala Tyr Ser Gly Leu
    1250                1255                1260                
Val Ser Ser Leu Gln Gly Leu Pro Ala Glu Leu Gln Gln Pro Val Gly
1265                1270                1275                1280
Arg Ala Arg His Ser Leu Cys Glu Leu Tyr Gly Ile Val Ala Ser Ala
                1285                1290                1295    
Gly Ser Val Glu Glu Leu Pro Ala Glu Arg Leu Val Gln Ser Arg Glu
            1300                1305                1310        
Gly Val His Gln Ala Trp Gln Gly Leu Glu Gln Leu Leu Glu Gly Leu
        1315                1320                1325            
Gln His Asn Pro Pro Leu Ser Trp Leu Val Gly Pro Phe Ala Leu Pro
    1330                1335                1340                
Ala Gly Gly Gln
1345            


<210> 2381
<211> 780
<212> PRT
<213> Homo sapiens

<400> 2381
Lys Asp Ala Ser Met Thr Gln Ala Leu Cys Arg Met Ile Asp Trp Leu
 1               5                  10                  15      
Ser Trp Pro Leu Ala Gln His Val Asp Thr Trp Val Ile Ala Leu Leu
            20                  25                  30          
Lys Gly Leu Ala Ala Val Gln Lys Phe Thr Ile Leu Ile Asp Val Thr
        35                  40                  45              
Leu Leu Lys Ile Glu Leu Val Phe Asn Arg Leu Trp Phe Pro Leu Val
    50                  55                  60                  
Arg Pro Gly Ala Leu Ala Val Leu Ser His Met Leu Leu Ser Phe Gln
65                  70                  75                  80  
His Ser Pro Glu Ala Phe His Leu Ile Val Pro His Val Val Asn Leu
                85                  90                  95      
Val His Ser Phe Lys Asn Asp Gly Leu Pro Ser Ser Thr Ala Phe Leu
            100                 105                 110         
Val Gln Leu Thr Glu Leu Ile His Cys Met Met Tyr His Tyr Ser Gly
        115                 120                 125             
Phe Pro Asp Leu Tyr Glu Pro Ile Leu Glu Ala Ile Lys Asp Phe Pro
    130                 135                 140                 
Lys Pro Ser Glu Glu Lys Ile Lys Leu Ile Leu Asn Gln Ser Ala Trp
145                 150                 155                 160 
Thr Ser Gln Ser Asn Ser Leu Ala Ser Cys Leu Ser Arg Leu Ser Gly
                165                 170                 175     
Lys Ser Glu Thr Gly Lys Thr Gly Leu Ile Asn Leu Gly Asn Thr Cys
            180                 185                 190         
Tyr Met Asn Ser Val Ile Gln Ala Leu Phe Met Ala Thr Asp Phe Arg
        195                 200                 205             
Arg Gln Val Leu Ser Leu Asn Leu Asn Gly Cys Asn Ser Leu Met Lys
    210                 215                 220                 
Lys Leu Gln His Leu Phe Ala Phe Leu Ala His Thr Gln Arg Glu Ala
225                 230                 235                 240 
Tyr Ala Pro Arg Ile Phe Phe Glu Ala Ser Arg Pro Pro Trp Phe Thr
                245                 250                 255     
Pro Arg Ser Gln Gln Asp Cys Ser Glu Tyr Leu Arg Phe Leu Leu Asp
            260                 265                 270         
Arg Leu His Glu Glu Glu Lys Ile Leu Lys Val Gln Ala Ser His Lys
        275                 280                 285             
Pro Ser Glu Ile Leu Glu Cys Ser Glu Thr Ser Leu Gln Glu Val Ala
    290                 295                 300                 
Ser Lys Ala Ala Val Leu Thr Glu Thr Pro Arg Thr Ser Asp Gly Glu
305                 310                 315                 320 
Lys Thr Leu Ile Glu Lys Met Phe Gly Gly Lys Leu Arg Thr His Ile
                325                 330                 335     
Arg Cys Leu Asn Cys Arg Ser Thr Ser Gln Lys Val Glu Ala Phe Thr
            340                 345                 350         
Asp Leu Ser Leu Ala Phe Cys Pro Ser Ser Ser Leu Glu Asn Met Ser
        355                 360                 365             
Val Gln Asp Pro Ala Ser Ser Pro Ser Ile Gln Asp Gly Gly Leu Met
    370                 375                 380                 
Gln Ala Ser Val Pro Gly Pro Ser Glu Glu Pro Val Val Tyr Asn Pro
385                 390                 395                 400 
Thr Thr Ala Ala Phe Ile Cys Asp Ser Leu Val Asn Glu Lys Thr Ile
                405                 410                 415     
Gly Ser Pro Pro Asn Glu Phe Tyr Cys Ser Glu Asn Thr Ser Val Pro
            420                 425                 430         
Asn Glu Ser Asn Lys Ile Leu Val Asn Lys Asp Val Pro Gln Lys Pro
        435                 440                 445             
Gly Gly Glu Thr Thr Pro Ser Val Thr Asp Leu Leu Asn Tyr Phe Leu
    450                 455                 460                 
Ala Pro Glu Ile Leu Thr Gly Asp Asn Gln Tyr Tyr Cys Glu Asn Cys
465                 470                 475                 480 
Ala Ser Leu Gln Asn Ala Glu Lys Thr Met Gln Ile Thr Glu Glu Pro
                485                 490                 495     
Glu Tyr Leu Ile Leu Thr Leu Leu Arg Phe Ser Tyr Asp Gln Lys Tyr
            500                 505                 510         
His Val Arg Arg Lys Ile Leu Asp Asn Val Ser Leu Pro Leu Val Leu
        515                 520                 525             
Glu Leu Pro Val Lys Arg Ile Thr Ser Phe Ser Ser Leu Ser Glu Ser
    530                 535                 540                 
Trp Ser Val Asp Val Asp Phe Thr Asp Leu Ser Glu Asn Leu Ala Lys
545                 550                 555                 560 
Lys Leu Lys Pro Ser Gly Thr Asp Glu Ala Ser Cys Thr Lys Leu Val
                565                 570                 575     
Pro Tyr Leu Leu Ser Ser Val Val Val His Ser Gly Ile Ser Ser Glu
            580                 585                 590         
Ser Gly His Tyr Tyr Ser Tyr Ala Arg Asn Ile Thr Ser Thr Asp Ser
        595                 600                 605             
Ser Tyr Gln Met Tyr His Gln Ser Glu Ala Leu Ala Leu Ala Ser Ser
    610                 615                 620                 
Gln Ser His Leu Leu Gly Arg Asp Ser Pro Ser Ala Val Phe Glu Gln
625                 630                 635                 640 
Asp Leu Glu Asn Lys Glu Met Ser Lys Glu Trp Phe Leu Phe Asn Asp
                645                 650                 655     
Ser Arg Val Thr Phe Thr Ser Phe Gln Ser Val Gln Lys Ile Thr Ser
            660                 665                 670         
Arg Phe Pro Lys Asp Thr Ala Tyr Val Leu Leu Tyr Lys Lys Gln His
        675                 680                 685             
Ser Thr Asn Gly Leu Ser Gly Asn Asn Pro Thr Ser Gly Leu Trp Ile
    690                 695                 700                 
Asn Gly Asp Pro Pro Leu Gln Lys Glu Leu Met Asp Ala Ile Thr Lys
705                 710                 715                 720 
Asp Asn Lys Leu Tyr Leu Gln Glu Gln Glu Leu Asn Ala Arg Ala Arg
                725                 730                 735     
Ala Leu Gln Ala Ala Ser Ala Ser Cys Ser Phe Arg Pro Asn Gly Phe
            740                 745                 750         
Asp Asp Asn Asp Pro Pro Gly Ser Cys Gly Pro Thr Gly Gly Gly Gly
        755                 760                 765             
Gly Gly Gly Phe Asn Thr Val Gly Arg Leu Val Phe
    770                 775                 780 


<210> 2382
<211> 645
<212> PRT
<213> Homo sapiens

<400> 2382
Ser Gly Val Pro Val Glu Glu Thr Lys Lys Gln Lys Leu Ser Glu Cys
 1               5                  10                  15      
Ser Leu Thr Lys Gly Gln Asp Gly Leu Gln Asn Asp Phe Leu Ser Ile
            20                  25                  30          
Ser Glu Asp Val Pro Arg Pro Pro Asp Thr Val Ser Thr Gly Lys Gly
        35                  40                  45              
Gly Lys Asn Ser Glu Ala Gln Leu Glu Asp Glu Glu Glu Glu Glu Glu
    50                  55                  60                  
Asp Gly Leu Ser Glu Glu Cys Glu Glu Glu Glu Ser Glu Ser Phe Ala
65                  70                  75                  80  
Asp Met Met Lys His Gly Leu Thr Glu Ala Asp Val Gly Ile Thr Lys
                85                  90                  95      
Phe Val Ser Ser His Gln Gly Phe Ser Gly Ile Leu Lys Glu Arg Tyr
            100                 105                 110         
Ser Asp Phe Val Val His Glu Ile Gly Lys Asp Gly Arg Ile Ser His
        115                 120                 125             
Leu Asn Asp Leu Ser Ile Pro Val Asp Glu Glu Asp Pro Ser Glu Asp
    130                 135                 140                 
Ile Phe Thr Val Leu Thr Ala Glu Glu Lys Gln Arg Leu Glu Glu Leu
145                 150                 155                 160 
Gln Leu Phe Lys Asn Lys Glu Thr Ser Val Ala Ile Glu Val Ile Glu
                165                 170                 175     
Asp Thr Lys Glu Lys Arg Thr Ile Ile His Gln Ala Ile Lys Ser Leu
            180                 185                 190         
Phe Pro Gly Leu Glu Thr Lys Thr Glu Asp Arg Glu Gly Lys Lys Tyr
        195                 200                 205             
Ile Val Ala Tyr His Ala Ala Gly Lys Lys Ala Leu Ala Lys Val Arg
    210                 215                 220                 
Thr Ala Ala Asp Pro Arg Lys His Ser Trp Pro Lys Ser Arg Gly Ser
225                 230                 235                 240 
Tyr Cys His Phe Val Leu Tyr Lys Glu Asn Lys Asp Thr Met Asp Ala
                245                 250                 255     
Ile Asn Val Leu Ser Lys Tyr Leu Arg Val Lys Pro Asn Ile Phe Ser
            260                 265                 270         
Tyr Met Gly Thr Lys Asp Lys Arg Ala Ile Thr Val Gln Glu Ile Ala
        275                 280                 285             
Val Leu Lys Ile Thr Ala Gln Arg Leu Ala His Leu Asn Lys Cys Leu
    290                 295                 300                 
Met Asn Phe Lys Leu Gly Asn Phe Ser Tyr Gln Lys Asn Pro Leu Lys
305                 310                 315                 320 
Leu Gly Glu Leu Gln Gly Asn His Phe Thr Val Val Leu Arg Asn Ile
                325                 330                 335     
Thr Gly Thr Asp Asp Gln Val Gln Gln Ala Met Asn Ser Leu Lys Glu
            340                 345                 350         
Ile Gly Phe Ile Asn Tyr Tyr Gly Met Gln Arg Phe Gly Thr Thr Ala
        355                 360                 365             
Val Pro Thr Tyr Gln Val Gly Arg Ala Ile Leu Gln Asn Ser Trp Thr
    370                 375                 380                 
Glu Val Met Asp Leu Ile Leu Lys Pro Arg Ser Gly Ala Glu Lys Gly
385                 390                 395                 400 
Tyr Leu Val Lys Cys Arg Glu Glu Trp Ala Lys Thr Lys Asp Pro Thr
                405                 410                 415     
Ala Ala Leu Arg Lys Leu Pro Val Lys Arg Cys Val Glu Gly Gln Leu
            420                 425                 430         
Leu Arg Gly Leu Ser Lys Tyr Gly Met Lys Asn Ile Val Ser Ala Phe
        435                 440                 445             
Gly Ile Ile Pro Arg Asn Asn Arg Leu Met Tyr Ile His Ser Tyr Gln
    450                 455                 460                 
Ser Tyr Val Trp Asn Asn Met Val Ser Lys Arg Ile Glu Asp Tyr Gly
465                 470                 475                 480 
Leu Lys Pro Val Pro Gly Asp Leu Val Leu Lys Gly Ala Thr Ala Thr
                485                 490                 495     
Tyr Ile Glu Glu Asp Asp Val Asn Asn Tyr Ser Ile His Asp Val Val
            500                 505                 510         
Met Pro Leu Pro Gly Phe Asp Val Ile Tyr Pro Lys His Lys Ile Gln
        515                 520                 525             
Glu Ala Tyr Arg Glu Met Leu Thr Ala Asp Asn Leu Asp Ile Asp Asn
    530                 535                 540                 
Met Arg His Lys Ile Arg Asp Tyr Ser Leu Ser Gly Ala Tyr Arg Lys
545                 550                 555                 560 
Ile Ile Ile Arg Pro Gln Asn Val Ser Trp Glu Val Val Ala Tyr Asp
                565                 570                 575     
Asp Pro Lys Ile Pro Leu Phe Asn Thr Asp Val Asp Asn Leu Glu Gly
            580                 585                 590         
Lys Thr Pro Pro Val Phe Ala Ser Glu Gly Lys Tyr Arg Ala Leu Lys
        595                 600                 605             
Met Asp Phe Ser Leu Pro Pro Ser Thr Tyr Ala Thr Met Ala Ile Arg
    610                 615                 620                 
Glu Val Leu Lys Met Asp Thr Ser Ile Lys Asn Gln Thr Gln Leu Asn
625                 630                 635                 640 
Thr Thr Trp Leu Arg
                645 


<210> 2383
<211> 821
<212> PRT
<213> Homo sapiens

<400> 2383
Ala Met Leu Arg Leu Gly Leu Cys Ala Ala Ala Leu Leu Cys Val Cys
 1               5                  10                  15      
Arg Pro Gly Ala Val Arg Ala Asp Cys Trp Leu Ile Glu Gly Asp Lys
            20                  25                  30          
Gly Tyr Val Trp Leu Ala Ile Cys Ser Gln Asn Gln Pro Pro Tyr Glu
        35                  40                  45              
Thr Ile Pro Gln His Ile Asn Ser Thr Val His Asp Leu Arg Leu Asn
    50                  55                  60                  
Glu Asn Lys Leu Lys Ala Val Leu Tyr Ser Ser Leu Asn Arg Phe Gly
65                  70                  75                  80  
Asn Leu Thr Asp Leu Asn Leu Thr Lys Asn Glu Ile Ser Tyr Ile Glu
                85                  90                  95      
Asp Gly Ala Phe Leu Gly Gln Ser Ser Leu Gln Val Leu Gln Leu Gly
            100                 105                 110         
Tyr Asn Lys Leu Ser Asn Leu Thr Glu Gly Met Leu Arg Gly Met Ser
        115                 120                 125             
Arg Leu Gln Phe Leu Phe Val Gln His Asn Leu Ile Glu Val Val Thr
    130                 135                 140                 
Pro Thr Ala Phe Ser Glu Cys Pro Ser Leu Ile Ser Ile Asp Leu Ser
145                 150                 155                 160 
Ser Asn Arg Leu Ser Arg Leu Asp Gly Ala Thr Phe Ala Ser Leu Ala
                165                 170                 175     
Ser Leu Met Val Cys Glu Leu Ala Gly Asn Pro Phe Asn Cys Glu Cys
            180                 185                 190         
Asp Leu Phe Gly Phe Leu Ala Trp Leu Val Val Phe Asn Asn Val Thr
        195                 200                 205             
Lys Asn Tyr Asp Arg Leu Gln Cys Glu Ser Pro Arg Glu Phe Ala Gly
    210                 215                 220                 
Tyr Pro Leu Leu Val Pro Arg Pro Tyr His Ser Leu Asn Ala Ile Ile
225                 230                 235                 240 
Val Leu Gln Ala Lys Cys Arg Asn Gly Ser Leu Pro Ala Arg Pro Val
                245                 250                 255     
Ser His Pro Thr Pro Tyr Ser Thr Asp Ala Gln Arg Glu Pro Asp Glu
            260                 265                 270         
Asn Ser Gly Phe Asn Pro Asp Glu Ile Leu Ser Val Glu Pro Pro Ala
        275                 280                 285             
Ser Ser Thr Thr Asp Ala Ser Ala Gly Pro Ala Ile Lys Leu His His
    290                 295                 300                 
Val Thr Phe Thr Ser Ala Thr Leu Val Val Ile Ile Pro His Pro Tyr
305                 310                 315                 320 
Ser Lys Met Tyr Ile Leu Val Gln Tyr Asn Asn Ser Tyr Phe Ser Asp
                325                 330                 335     
Val Met Thr Leu Lys Asn Lys Lys Glu Ile Val Thr Leu Asp Lys Leu
            340                 345                 350         
Arg Ala His Thr Glu Tyr Thr Phe Cys Val Thr Ser Leu Arg Asn Ser
        355                 360                 365             
Arg Arg Phe Asn His Thr Cys Leu Thr Phe Thr Thr Arg Asp Pro Val
    370                 375                 380                 
Pro Gly Asp Leu Ala Pro Ser Thr Ser Thr Thr Thr His Tyr Ile Met
385                 390                 395                 400 
Thr Ile Leu Gly Cys Leu Phe Gly Met Val Ile Val Leu Gly Ala Val
                405                 410                 415     
Tyr Tyr Cys Leu Arg Lys Arg Arg Met Gln Glu Glu Lys Gln Lys Ser
            420                 425                 430         
Val Asn Val Lys Lys Thr Ile Leu Glu Met Arg Tyr Gly Ala Asp Val
        435                 440                 445             
Asp Ala Gly Ser Ile Val His Ala Ala Gln Lys Leu Gly Glu Pro Pro
    450                 455                 460                 
Val Leu Pro Val Ser Arg Met Ala Ser Ile Pro Ser Met Ile Gly Glu
465                 470                 475                 480 
Lys Leu Pro Thr Ala Lys Gly Leu Glu Ala Gly Leu Asp Thr Pro Lys
                485                 490                 495     
Val Ala Thr Lys Gly Asn Tyr Ile Glu Val Arg Thr Gly Ala Gly Gly
            500                 505                 510         
Asp Gly Leu Ala Arg Pro Glu Asp Asp Leu Pro Asp Leu Glu Asn Gly
        515                 520                 525             
Gln Gly Ser Ala Ala Glu Ile Ser Thr Ile Ala Lys Glu Val Asp Lys
    530                 535                 540                 
Val Asn Gln Ile Ile Asn Asn Cys Ile Asp Ala Leu Lys Leu Asp Ser
545                 550                 555                 560 
Ala Ser Phe Leu Gly Gly Gly Ser Ser Ser Gly Asp Pro Glu Leu Ala
                565                 570                 575     
Phe Glu Cys Gln Ser Leu Pro Ala Ala Ala Ala Ala Ser Ser Ala Thr
            580                 585                 590         
Gly Pro Gly Ala Leu Glu Arg Pro Ser Phe Leu Ser Pro Ser Tyr Lys
        595                 600                 605             
Glu Ser Ser His His Pro Leu Gln Arg Gln Leu Ser Ala Asp Ala Ala
    610                 615                 620                 
Val Thr Arg Lys Thr Cys Ser Val Ser Ser Ser Gly Ser Ile Lys Ser
625                 630                 635                 640 
Ala Lys Val Phe Ser Leu Asp Val Pro Asp His Pro Ala Ala Thr Gly
                645                 650                 655     
Leu Ala Lys Gly Asp Ser Lys Tyr Ile Glu Lys Gly Ser Pro Leu Asn
            660                 665                 670         
Ser Pro Leu Asp Arg Leu Pro Leu Val Pro Ala Gly Ser Gly Gly Gly
        675                 680                 685             
Ser Gly Gly Gly Gly Gly Ile His His Leu Glu Val Lys Pro Ala Tyr
    690                 695                 700                 
His Cys Ser Glu His Arg His Ser Phe Pro Ala Leu Tyr Tyr Glu Glu
705                 710                 715                 720 
Gly Ala Asp Ser Leu Ser Gln Arg Val Ser Phe Leu Lys Pro Leu Thr
                725                 730                 735     
Arg Ser Lys Arg Asp Ser Thr Tyr Ser Gln Leu Ser Pro Arg His Tyr
            740                 745                 750         
Tyr Ser Gly Tyr Ser Ser Ser Pro Glu Tyr Ser Ser Glu Ser Thr His
        755                 760                 765             
Lys Ile Trp Glu Arg Phe Arg Pro Tyr Lys Lys His His Arg Glu Glu
    770                 775                 780                 
Val Tyr Met Ala Ala Gly His Ala Leu Arg Lys Lys Val Gln Phe Ala
785                 790                 795                 800 
Lys Asp Glu Asp Leu His Asp Ile Leu Asp Tyr Trp Lys Gly Val Ser
                805                 810                 815     
Ala Gln Gln Lys Leu
            820     


<210> 2384
<211> 760
<212> PRT
<213> Homo sapiens

<400> 2384
Leu Ala Ser Gly Leu Leu Gln Cys Gly Gly Val Arg Glu Glu Gly Ile
 1               5                  10                  15      
His Pro His Pro Pro Lys Pro Phe Ser Ser Pro Phe Leu Ala Ser Asp
            20                  25                  30          
Ile Gly Ala Leu Asn Glu Leu Glu Leu Cys Leu Trp Arg Ala Gly Trp
        35                  40                  45              
Ser Leu Leu Leu Cys Asp Glu Ile Gly Asp Glu Leu Leu Ala Leu Lys
    50                  55                  60                  
Met Leu Leu Trp Ile Leu Leu Leu Glu Thr Ser Leu Cys Phe Ala Ala
65                  70                  75                  80  
Gly Asn Val Thr Gly Asp Val Cys Lys Glu Lys Ile Cys Ser Cys Asn
                85                  90                  95      
Glu Ile Glu Gly Asp Leu His Val Asp Cys Glu Lys Lys Gly Phe Thr
            100                 105                 110         
Ser Leu Gln Arg Phe Thr Ala Pro Thr Ser Gln Phe Tyr His Leu Phe
        115                 120                 125             
Leu His Gly Asn Ser Leu Thr Arg Leu Phe Pro Asn Glu Phe Ala Asn
    130                 135                 140                 
Phe Tyr Asn Ala Val Ser Leu His Met Glu Asn Asn Gly Leu His Glu
145                 150                 155                 160 
Ile Val Pro Gly Ala Phe Leu Gly Leu Gln Leu Val Lys Arg Leu His
                165                 170                 175     
Ile Asn Asn Asn Lys Ile Lys Ser Phe Arg Lys Gln Thr Phe Leu Gly
            180                 185                 190         
Leu Asp Asp Leu Glu Tyr Leu Gln Ala Asp Phe Asn Leu Leu Arg Asp
        195                 200                 205             
Ile Asp Pro Gly Ala Phe Gln Asp Leu Asn Lys Leu Glu Val Leu Ile
    210                 215                 220                 
Leu Asn Asp Asn Leu Ile Ser Thr Leu Pro Ala Asn Val Phe Gln Tyr
225                 230                 235                 240 
Val Pro Ile Thr His Leu Asp Leu Arg Gly Asn Arg Leu Lys Thr Leu
                245                 250                 255     
Pro Tyr Glu Glu Val Leu Glu Gln Ile Pro Gly Ile Ala Glu Ile Leu
            260                 265                 270         
Leu Glu Asp Asn Pro Trp Asp Cys Thr Cys Asp Leu Leu Ser Leu Lys
        275                 280                 285             
Glu Trp Leu Glu Asn Ile Pro Lys Asn Ala Leu Ile Gly Arg Val Val
    290                 295                 300                 
Cys Glu Ala Pro Thr Arg Leu Gln Gly Lys Asp Leu Asn Glu Thr Thr
305                 310                 315                 320 
Glu Gln Asp Leu Cys Pro Leu Lys Asn Arg Val Asp Ser Ser Leu Pro
                325                 330                 335     
Ala Pro Pro Ala Gln Glu Glu Thr Phe Ala Pro Gly Pro Leu Pro Thr
            340                 345                 350         
Pro Phe Lys Thr Asn Gly Gln Glu Asp His Ala Thr Pro Gly Ser Ala
        355                 360                 365             
Pro Asn Gly Gly Thr Lys Ile Pro Gly Asn Trp Gln Ile Lys Ile Arg
    370                 375                 380                 
Pro Thr Ala Ala Ile Ala Thr Gly Ser Ser Arg Asn Lys Pro Leu Ala
385                 390                 395                 400 
Asn Ser Leu Pro Cys Pro Gly Gly Cys Ser Cys Asp His Ile Pro Gly
                405                 410                 415     
Ser Gly Leu Lys Met Asn Cys Asn Asn Arg Asn Val Ser Ser Leu Ala
            420                 425                 430         
Asp Leu Lys Pro Lys Leu Ser Asn Val Gln Glu Leu Phe Leu Arg Asp
        435                 440                 445             
Asn Lys Ile His Ser Ile Arg Lys Ser His Phe Val Asp Tyr Lys Asn
    450                 455                 460                 
Leu Ile Leu Leu Asp Leu Gly Asn Asn Asn Ile Ala Thr Val Glu Asn
465                 470                 475                 480 
Asn Thr Phe Lys Asn Leu Leu Asp Leu Arg Trp Leu Tyr Met Asp Ser
                485                 490                 495     
Asn Tyr Leu Asp Thr Leu Ser Arg Glu Lys Phe Ala Gly Leu Gln Asn
            500                 505                 510         
Leu Glu Tyr Leu Asn Val Glu Tyr Asn Ala Ile Gln Leu Ile Leu Pro
        515                 520                 525             
Gly Thr Phe Asn Ala Met Pro Lys Leu Arg Ile Leu Ile Leu Asn Asn
    530                 535                 540                 
Asn Leu Leu Arg Ser Leu Pro Val Asp Val Phe Ala Gly Val Ser Leu
545                 550                 555                 560 
Ser Lys Leu Ser Leu His Asn Asn Tyr Phe Met Tyr Leu Pro Val Ala
                565                 570                 575     
Gly Val Leu Asp Gln Leu Thr Ser Ile Ile Gln Ile Asp Leu His Gly
            580                 585                 590         
Asn Pro Trp Glu Cys Ser Cys Thr Ile Val Pro Phe Lys Gln Trp Ala
        595                 600                 605             
Glu Arg Leu Gly Ser Glu Val Leu Met Ser Asp Leu Lys Cys Glu Thr
    610                 615                 620                 
Pro Val Asn Phe Phe Arg Lys Asp Phe Met Leu Leu Ser Asn Asp Glu
625                 630                 635                 640 
Ile Cys Pro Gln Leu Tyr Ala Arg Ile Ser Pro Thr Leu Thr Ser His
                645                 650                 655     
Ser Lys Asn Ser Thr Gly Leu Ala Glu Thr Gly Thr His Ser Asn Ser
            660                 665                 670         
Tyr Leu Asp Thr Ser Arg Val Ser Ile Ser Val Leu Val Pro Gly Leu
        675                 680                 685             
Leu Leu Val Phe Val Thr Ser Ala Phe Thr Val Val Gly Met Leu Val
    690                 695                 700                 
Phe Ile Leu Arg Asn Arg Lys Arg Ser Lys Arg Arg Asp Ala Asn Ser
705                 710                 715                 720 
Ser Ala Ser Glu Ile Asn Ser Leu Gln Thr Val Cys Asp Ser Ser Tyr
                725                 730                 735     
Trp His Asn Gly Pro Tyr Asn Ala Asp Gly Ala His Arg Val Tyr Asp
            740                 745                 750         
Cys Gly Ser His Ser Leu Ser Asp
        755                 760 


<210> 2385
<211> 452
<212> PRT
<213> Homo sapiens

<400> 2385
Lys Val Gly Ala Met Ala Leu Thr Leu Leu Glu Asp Trp Cys Lys Gly
 1               5                  10                  15      
Met Asp Met Asp Pro Arg Lys Ala Leu Leu Ile Val Gly Ile Pro Met
            20                  25                  30          
Glu Cys Ser Glu Val Glu Ile Gln Asp Thr Val Lys Ala Gly Leu Gln
        35                  40                  45              
Pro Leu Cys Ala Tyr Arg Val Leu Gly Arg Met Phe Arg Arg Glu Asp
    50                  55                  60                  
Asn Ala Lys Ala Val Phe Ile Glu Leu Ala Asp Thr Val Asn Tyr Thr
65                  70                  75                  80  
Thr Leu Pro Ser His Ile Pro Gly Lys Gly Gly Ser Trp Glu Val Val
                85                  90                  95      
Val Lys Pro Arg Asn Pro Asp Asp Glu Phe Leu Ser Arg Leu Asn Tyr
            100                 105                 110         
Phe Leu Lys Asp Glu Gly Arg Ser Met Thr Asp Val Ala Arg Ala Leu
        115                 120                 125             
Gly Cys Cys Ser Leu Pro Ala Glu Ser Leu Asp Ala Glu Val Met Pro
    130                 135                 140                 
Gln Val Arg Ser Pro Pro Leu Glu Pro Pro Lys Glu Ser Met Trp Tyr
145                 150                 155                 160 
Arg Lys Leu Lys Val Phe Ser Gly Thr Ala Ser Pro Ser Pro Gly Glu
                165                 170                 175     
Glu Thr Phe Glu Asp Trp Leu Glu Gln Val Thr Glu Ile Met Pro Ile
            180                 185                 190         
Trp Gln Val Ser Glu Val Glu Lys Arg Arg Arg Leu Leu Glu Ser Leu
        195                 200                 205             
Arg Gly Pro Ala Leu Ser Ile Met Arg Val Leu Gln Ala Asn Asn Asp
    210                 215                 220                 
Ser Ile Thr Val Glu Gln Cys Leu Asp Ala Leu Lys Gln Ile Phe Gly
225                 230                 235                 240 
Asp Lys Glu Asp Phe Arg Ala Ser Gln Phe Arg Phe Leu Gln Thr Ser
                245                 250                 255     
Pro Lys Ile Gly Glu Lys Val Ser Thr Phe Leu Leu Arg Leu Glu Pro
            260                 265                 270         
Leu Leu Gln Lys Ala Val His Lys Ser Pro Leu Ser Val Arg Ser Thr
        275                 280                 285             
Asp Met Ile Arg Leu Lys His Leu Leu Ala Arg Val Ala Met Thr Pro
    290                 295                 300                 
Ala Leu Arg Gly Lys Leu Glu Leu Leu Asp Gln Arg Gly Cys Pro Pro
305                 310                 315                 320 
Asn Phe Leu Glu Leu Met Lys Leu Ile Arg Asp Glu Glu Glu Trp Glu
                325                 330                 335     
Asn Thr Glu Ala Val Met Lys Asn Lys Glu Lys Pro Ser Gly Arg Gly
            340                 345                 350         
Arg Gly Ala Ser Gly Arg Gln Ala Arg Ala Glu Ala Ser Val Ser Ala
        355                 360                 365             
Pro Gln Ala Thr Val Gln Ala Arg Ser Phe Ser Asp Ser Ser Pro Gln
    370                 375                 380                 
Thr Ile Gln Gly Gly Leu Pro Pro Leu Val Lys Arg Arg Arg Leu Leu
385                 390                 395                 400 
Gly Ser Glu Ser Thr Arg Gly Glu Asp His Gly Gln Ala Thr Tyr Pro
                405                 410                 415     
Lys Ala Glu Asn Gln Thr Pro Gly Arg Glu Gly Pro Gln Ala Ala Gly
            420                 425                 430         
Glu Glu Leu Gly Asn Glu Ala Gly Ala Gly Ala Met Ser His Pro Lys
        435                 440                 445             
Pro Trp Glu Thr
    450         


<210> 2386
<211> 704
<212> PRT
<213> Homo sapiens

<400> 2386
Val Leu Gly Gly Leu Leu Leu Leu Gly Val Ala Gln Leu Gly Leu Phe
 1               5                  10                  15      
Leu Glu Glu Lys Leu Arg Glu His Leu Ala Glu Lys Glu Lys Leu Asn
            20                  25                  30          
Glu Glu Arg Leu Glu Gln Glu Glu Lys Leu Lys Ala Lys Ile Arg Gln
        35                  40                  45              
Leu Thr Glu Glu Lys Ala Ala Leu Glu Glu Tyr Ile Thr Gln Glu Arg
    50                  55                  60                  
Asn Arg Ala Lys Glu Thr Leu Glu Glu Glu Arg Lys Arg Met Gln Glu
65                  70                  75                  80  
Leu Glu Ser Leu Leu Ala Gln Gln Lys Lys Ala Leu Ala Lys Ser Ile
                85                  90                  95      
Thr Gln Glu Lys Asn Arg Val Lys Glu Ala Leu Glu Glu Glu Gln Thr
            100                 105                 110         
Arg Val Gln Glu Leu Glu Glu Arg Leu Ala Arg Gln Lys Glu Ile Ser
        115                 120                 125             
Glu Ser Asn Ile Ala Tyr Glu Lys Arg Lys Ala Lys Glu Ala Met Glu
    130                 135                 140                 
Lys Glu Lys Lys Lys Val Gln Asp Leu Glu Asn Arg Leu Thr Lys Gln
145                 150                 155                 160 
Lys Glu Glu Leu Glu Leu Lys Glu Gln Lys Glu Asp Val Leu Asn Asn
                165                 170                 175     
Lys Leu Ser Asp Ala Leu Ala Met Val Glu Glu Thr Gln Lys Thr Lys
            180                 185                 190         
Ala Thr Glu Ser Leu Lys Ala Glu Ser Leu Ala Leu Lys Leu Asn Glu
        195                 200                 205             
Thr Leu Ala Glu Leu Glu Thr Thr Lys Thr Lys Met Ile Met Val Glu
    210                 215                 220                 
Glu Arg Leu Ile Leu Gln Gln Lys Met Val Lys Ala Leu Gln Asp Glu
225                 230                 235                 240 
Gln Glu Ser Gln Arg His Gly Phe Gly Glu Glu Ile Met Glu Tyr Lys
                245                 250                 255     
Glu Gln Ile Lys Gln His Ala Gln Thr Ile Val Ser Leu Glu Glu Lys
            260                 265                 270         
Leu Gln Lys Val Thr Gln His His Lys Lys Ile Glu Gly Glu Ile Ala
        275                 280                 285             
Thr Leu Lys Asp Asn Asp Pro Ala Pro Lys Glu Glu Arg Pro Gln Asp
    290                 295                 300                 
Pro Leu Val Ala Pro Met Thr Glu Ser Ser Ala Lys Asp Met Ala Tyr
305                 310                 315                 320 
Glu His Leu Ile Asp Asp Leu Leu Ala Ala Gln Lys Glu Ile Leu Ser
                325                 330                 335     
Gln Gln Glu Val Ile Met Lys Leu Arg Lys Asp Leu Thr Glu Ala His
            340                 345                 350         
Ser Arg Met Ser Asp Leu Arg Gly Glu Leu Asn Glu Lys Gln Lys Met
        355                 360                 365             
Glu Leu Glu Gln Asn Val Val Leu Val Gln Gln Gln Ser Lys Glu Leu
    370                 375                 380                 
Ser Val Leu Lys Glu Lys Met Ala Gln Met Ser Ser Leu Val Glu Lys
385                 390                 395                 400 
Lys Asp Arg Glu Leu Lys Ala Leu Glu Glu Ala Leu Arg Ala Ser Gln
                405                 410                 415     
Glu Lys His Arg Leu Gln Leu Asn Thr Glu Lys Glu Gln Lys Pro Arg
            420                 425                 430         
Lys Lys Thr Gln Thr Cys Asp Thr Ser Val Gln Ile Glu Pro Val His
        435                 440                 445             
Thr Glu Ala Phe Ser Ser Ser Gln Glu Gln Gln Ser Phe Ser Asp Leu
    450                 455                 460                 
Gly Val Arg Cys Lys Gly Ser Arg His Glu Glu Val Ile Gln Arg Gln
465                 470                 475                 480 
Lys Lys Ala Leu Ser Glu Leu Arg Ala Arg Ile Lys Glu Leu Glu Lys
                485                 490                 495     
Ala Arg Ser Pro Asp His Lys Asp His Gln Asn Glu Ser Phe Leu Asp
            500                 505                 510         
Leu Lys Asn Leu Arg Met Glu Asn Asn Val Gln Lys Ile Leu Leu Asp
        515                 520                 525             
Ala Lys Pro Asp Leu Pro Thr Leu Ser Arg Ile Glu Ile Leu Ala Pro
    530                 535                 540                 
Gln Asn Gly Leu Cys Asn Ala Arg Phe Gly Ser Ala Met Glu Lys Ser
545                 550                 555                 560 
Gly Lys Met Asp Val Ala Glu Ala Leu Glu Leu Ser Glu Lys Leu Tyr
                565                 570                 575     
Leu Asp Met Ser Lys Thr Leu Gly Ser Leu Met Asn Ile Lys Asn Met
            580                 585                 590         
Ser Gly His Val Ser Met Lys Tyr Leu Ser Arg Gln Glu Arg Glu Lys
        595                 600                 605             
Val Asn Gln Leu Arg Gln Arg Asp Leu Asp Leu Val Phe Asp Lys Ile
    610                 615                 620                 
Thr Gln Leu Lys Asn Gln Leu Gly Arg Lys Glu Glu Leu Leu Arg Gly
625                 630                 635                 640 
Tyr Glu Lys Asp Val Glu Gln Leu Arg Arg Ser Lys Val Ser Ile Glu
                645                 650                 655     
Met Tyr Gln Ser Gln Val Ala Lys Leu Glu Asp Asp Ile Tyr Lys Glu
            660                 665                 670         
Ala Glu Glu Lys Ala Leu Leu Lys Glu Ala Leu Glu Arg Met Glu His
        675                 680                 685             
Gln Leu Cys Gln Glu Lys Arg Ile Asn Arg Ala Ile Arg Gln Gln Lys
    690                 695                 700                 


<210> 2387
<211> 78
<212> PRT
<213> Homo sapiens

<400> 2387
Met Pro Glu Pro Ala Lys Ser Ala Pro Ala Pro Lys Lys Gly Ser Lys
 1               5                  10                  15      
Lys Ala Val Thr Lys Ala Gln Lys Lys Asp Gly Lys Lys Arg Lys Arg
            20                  25                  30          
Ser Arg Lys Glu Ser Tyr Ser Ile Tyr Val Tyr Lys Val Leu Lys Gln
        35                  40                  45              
Val His Pro Asp Thr Gly Ile Ser Ser Lys Ala Met Gly Ile Met Asn
    50                  55                  60                  
Ser Phe Val Asn Asp Ile Phe Glu Arg Ile Ala Gly Leu Pro
65                  70                  75              


<210> 2388
<211> 360
<212> PRT
<213> Homo sapiens

<400> 2388
Met Gly Phe Glu Leu Asp Arg Phe Asp Gly Asp Val Asp Pro Asp Leu
 1               5                  10                  15      
Lys Cys Ala Leu Cys His Lys Val Leu Glu Asp Pro Leu Thr Thr Pro
            20                  25                  30          
Cys Gly His Val Phe Cys Ala Gly Cys Val Leu Pro Trp Val Val Gln
        35                  40                  45              
Glu Gly Ser Cys Pro Ala Arg Cys Arg Gly Arg Leu Ser Ala Lys Glu
    50                  55                  60                  
Leu Asn His Val Leu Pro Leu Lys Arg Leu Ile Leu Lys Leu Asp Ile
65                  70                  75                  80  
Lys Cys Ala Tyr Ala Thr Arg Gly Cys Gly Arg Val Val Lys Leu Gln
                85                  90                  95      
Gln Leu Pro Glu His Leu Glu Arg Cys Asp Phe Ala Pro Ala Arg Cys
            100                 105                 110         
Arg His Ala Gly Cys Gly Gln Val Leu Leu Arg Arg Asp Val Glu Ala
        115                 120                 125             
His Met Arg Asp Ala Cys Asp Ala Arg Pro Val Gly Arg Cys Gln Glu
    130                 135                 140                 
Gly Cys Gly Leu Pro Leu Thr His Gly Glu Gln Arg Ala Gly Gly His
145                 150                 155                 160 
Cys Cys Ala Arg Ala Leu Arg Ala His Asn Gly Ala Leu Gln Ala Arg
                165                 170                 175     
Leu Gly Ala Leu His Lys Ala Leu Lys Lys Glu Ala Leu Arg Ala Gly
            180                 185                 190         
Lys Arg Glu Lys Ser Leu Val Ala Gln Leu Ala Ala Ala Gln Leu Glu
        195                 200                 205             
Leu Gln Met Thr Ala Leu Arg Tyr Gln Lys Lys Phe Thr Glu Tyr Ser
    210                 215                 220                 
Ala Arg Leu Asp Ser Leu Ser Arg Cys Val Ala Ala Pro Pro Gly Gly
225                 230                 235                 240 
Lys Gly Glu Glu Thr Lys Ser Leu Thr Leu Val Leu His Arg Asp Ser
                245                 250                 255     
Gly Ser Leu Gly Phe Asn Ile Ile Gly Gly Arg Pro Ser Val Asp Asn
            260                 265                 270         
His Asp Gly Ser Ser Ser Glu Gly Ile Phe Val Ser Lys Ile Val Asp
        275                 280                 285             
Ser Gly Pro Ala Ala Lys Glu Gly Gly Leu Gln Ile His Asp Arg Ile
    290                 295                 300                 
Ile Glu Met Arg Lys Leu Glu Leu Arg Thr Val Lys Leu Pro Lys Ala
305                 310                 315                 320 
His Ser Gln Asp Ser Asn Ala Gly Phe Ile Pro Gln Leu Leu Ser Leu
                325                 330                 335     
His Thr Pro Pro Leu Ser Cys Glu Lys Gly Gly Gly His Leu Ala Cys
            340                 345                 350         
Gly Gly Ala Tyr Leu Asn Cys Ile
        355                 360 


<210> 2389
<211> 971
<212> PRT
<213> Homo sapiens

<400> 2389
Met Gly Ser Phe Leu Ser Lys Leu Glu Leu Ser Pro Ser Ser Pro Ala
 1               5                  10                  15      
Gln Val Arg Thr Asp Leu Pro Glu Arg Pro Thr Lys Arg Arg Pro Pro
            20                  25                  30          
Gln Pro Leu His Gln Val His Arg Val Gln Phe Val His Arg Ala His
        35                  40                  45              
Pro Ala Pro Arg Tyr Arg Pro Val Arg Arg Arg Pro Asn Leu Asp Pro
    50                  55                  60                  
Ala Asn Pro Thr Thr Trp Leu Ala Asn Glu Ala Trp Arg Arg Phe Pro
65                  70                  75                  80  
Met Lys Lys Ser Gln Asn Ser Pro Leu Gly Pro Leu Pro Ser Asp Trp
                85                  90                  95      
Trp Glu Ser Tyr Leu Lys Arg Thr Ile Trp Ser Leu Arg His Pro Arg
            100                 105                 110         
Pro Ile Trp Ser Pro Val Thr Ile Arg Ile Thr Pro Pro Asp Gln Arg
        115                 120                 125             
Val Pro Pro Ser Thr Ser Pro Glu Asp Val Ile Ala Leu Ala Gly Leu
    130                 135                 140                 
Pro Pro Ser Glu Glu Leu Ala Asp Pro Cys Ser Lys Glu Thr Val Leu
145                 150                 155                 160 
Arg Ala Leu Arg Glu Cys Arg Lys Gly Lys Gly Arg Leu Glu Glu Pro
                165                 170                 175     
Leu Phe Pro Glu Ser Leu Asp Ser Lys Arg Arg Ser Pro Glu Thr Arg
            180                 185                 190         
Pro Ser Ala Phe Lys Pro Leu Met Lys Asn Gly Thr Leu Thr Ser Phe
        195                 200                 205             
Val Pro Arg Pro Gly Pro Leu Lys Arg Ser Leu His Ser Trp Gly Ser
    210                 215                 220                 
Asp His Ser Leu Thr Lys Arg Pro Asn Cys Ser Ser Met Ser Ser Leu
225                 230                 235                 240 
Ala Ser Ile Tyr Arg Gly Gly Thr Leu Ser Ser Lys Arg Asn Ala Ile
                245                 250                 255     
Gly Ser Ser Tyr Ser Ser Cys Arg Asn Phe Ser Asp Pro Trp Lys Arg
            260                 265                 270         
Ser Val Pro Ser Val Ser Phe Glu Thr Pro Glu Trp Pro Ile Lys Lys
        275                 280                 285             
Glu Lys Ser Cys His Arg Pro Ser Ser Pro Val Pro Leu Val Ser Asp
    290                 295                 300                 
Phe Glu Ser Leu Gly Gly Ser Glu Ser Ser Gly Gln Gln Asn Gln Lys
305                 310                 315                 320 
Ile Pro Gln Leu Pro Ser Ser Pro Glu Asn Leu Val Ser Glu Ile Pro
                325                 330                 335     
Pro Pro Gln Leu Gly Tyr Ala Val Ser Asp Glu Asn Leu Thr Leu Gly
            340                 345                 350         
Lys Lys Ala Glu Leu Gln Ser Thr Gly Glu Ala Thr Ser Val Ala His
        355                 360                 365             
Ser Pro Leu Lys Thr Pro Ser Leu Pro Thr Pro Pro Gly Cys Ser Gln
    370                 375                 380                 
Ser Glu Leu Leu Pro Gly Thr Ser Pro Asp Ser Lys Pro Thr Ala Thr
385                 390                 395                 400 
Phe Ile Leu Leu Thr Pro Thr Ser Pro Thr Leu Pro Val Thr Asp Thr
                405                 410                 415     
Thr Trp Pro Pro Ser Thr Ser Gln Ala Asp Arg Ser Pro Met Pro Pro
            420                 425                 430         
Asp Pro Pro Ala Pro Pro Thr Ile Gln Ser Thr Leu Leu Gly Met Val
        435                 440                 445             
Ser Ser Pro Thr Ser His Leu Ser Ala Ser Ala Pro Pro Asp Ala Thr
    450                 455                 460                 
Ser Ala His Leu Met Leu Lys Pro Ile Leu Gly Pro Leu His Asn Ser
465                 470                 475                 480 
Glu Ile Gly Ser Ser Ser Tyr Ser Arg Ile Ser Val Thr Ala Ala Ala
                485                 490                 495     
Ser Ser Ile Ser Ser Leu Ser Thr Ile Gln Gly Thr Leu Thr Pro Thr
            500                 505                 510         
Phe Lys Pro Ile Phe Gly Ser Ile Asp Pro Leu Lys Thr Thr Pro Met
        515                 520                 525             
Ile Ala Pro Phe Ser Ser Lys Gln Thr Pro Pro Pro Phe Thr His Ala
    530                 535                 540                 
Ser Thr His His Phe His Gly Leu Val Lys Ala Thr Ser Val Val Met
545                 550                 555                 560 
Ser Thr Thr Leu Ala Ser Thr Ser Lys Asp Ser Val Phe Lys Pro Pro
                565                 570                 575     
Leu Asp Phe Gly Val Val Asn Val Thr Ser Ala Val Gly Asn Thr Tyr
            580                 585                 590         
Ser Val Pro Ser Thr Cys Asp Thr Phe Leu Leu Gly Thr Ala Gln Ala
        595                 600                 605             
Phe Arg Ala Asp Phe Thr Pro Ala Thr Gly Phe Ile Phe Pro Pro His
    610                 615                 620                 
His His Pro Thr Ile Pro Thr Val His Thr Val Thr Met Phe Thr Gln
625                 630                 635                 640 
Val Leu Ser Ser Val Val Gln Ile Ser Pro Arg Ser Ser Thr Ala Asn
                645                 650                 655     
Phe Arg Gly Met Gly Ser Pro Leu Pro Ala Ser Ala Leu Val Ser Thr
            660                 665                 670         
Asn Trp Leu Ala Ser Thr Pro Ser Ile Ser Asn Leu Thr Pro Ala Ile
        675                 680                 685             
Thr Ser Pro Leu Gly Ser Ser Ser Arg Pro Pro Phe Pro Leu Ser Gln
    690                 695                 700                 
Gly Ala Asn Pro Gln Pro Ala Phe Gly Ala Thr Asn Gly Gln Lys Gln
705                 710                 715                 720 
Gly Pro Ser Gln Pro Ala Leu Met Pro Ser Val Ser Ser Ser Phe Leu
                725                 730                 735     
Phe Gly Ser Ser Ala Val Ala Leu Pro Thr Pro Met Pro Thr Pro Ala
            740                 745                 750         
Gln Pro Ala Phe Ile Ser Thr Thr Gln Ser Ala Leu Gly Cys Leu Thr
        755                 760                 765             
Pro Ser Ala Ser Thr Ser Gln Thr Pro Ala Ser Thr Trp Ser Gly Ile
    770                 775                 780                 
Gly Gly Ile Pro Ala Gly Phe Pro Ile Ser Gln Ala Ser Thr Thr Gly
785                 790                 795                 800 
Phe Arg Ile Val Ile Gln Thr His Gln Ser Gly Ala Phe Gly Ser Val
                805                 810                 815     
Phe Gly Ser Arg Ala Pro Gln Pro Phe Thr Phe Gly Gly Phe Val Thr
            820                 825                 830         
Pro Met Asp Cys Asp Glu Ser Gly Ile Ile Met Thr Gly Pro Asp Met
        835                 840                 845             
Ser Pro Thr Ser Gly Ala Phe Ser Ile Gly Ala Leu Pro Ser Gly Thr
    850                 855                 860                 
Thr Asn Thr Met Ile Pro Phe Gly Lys Gly Trp Ser Gln Asn Thr Glu
865                 870                 875                 880 
Gly Leu Pro Ser His Arg Thr Ala Phe Ser Leu Gly Arg Gly Ser Ile
                885                 890                 895     
Ser Ala Arg Lys Thr Met Ala Pro Ile Ala Gln Asn Thr Pro Val Pro
            900                 905                 910         
Gly Gln Ala Lys Ala Gly Ser Ser Val Gly Phe Gly Met Pro Phe Pro
        915                 920                 925             
Pro Ala Gln Gly Ser Val Gly Arg Gly Pro Phe Arg Ser Ser Ala Ser
    930                 935                 940                 
Ser Phe Ser Ile Gly Ala Lys Ser Lys Thr Pro Lys Asn Arg Glu Lys
945                 950                 955                 960 
Gly His Ser Arg Arg His His Ala Tyr Lys Lys
                965                 970     


<210> 2390
<211> 475
<212> PRT
<213> Homo sapiens

<400> 2390
Met Thr Thr Ile Leu Thr Tyr Pro Phe Lys Asn Leu Pro Thr Ala Ser
 1               5                  10                  15      
Lys Trp Ala Leu Arg Phe Ser Ile Arg Pro Leu Ser Cys Ser Ser Gln
            20                  25                  30          
Leu Arg Ala Ala Pro Ala Val Gln Thr Lys Thr Lys Lys Thr Leu Ala
        35                  40                  45              
Lys Pro Asn Ile Arg Asn Val Val Val Val Asp Gly Val Arg Thr Pro
    50                  55                  60                  
Phe Leu Leu Ser Gly Thr Ser Tyr Lys Asp Leu Met Pro His Asp Leu
65                  70                  75                  80  
Ala Arg Ala Ala Leu Thr Gly Leu Leu His Arg Thr Ser Val Pro Lys
                85                  90                  95      
Glu Val Val Asp Tyr Ile Ile Phe Gly Thr Val Ile Gln Glu Val Lys
            100                 105                 110         
Thr Ser Asn Val Ala Arg Glu Ala Ala Leu Gly Ala Gly Phe Ser Asp
        115                 120                 125             
Lys Thr Pro Ala His Thr Val Thr Met Ala Cys Ile Ser Ala Asn Gln
    130                 135                 140                 
Ala Met Thr Thr Gly Val Gly Leu Ile Ala Ser Gly Gln Cys Asp Val
145                 150                 155                 160 
Ile Val Ala Gly Gly Val Glu Leu Met Ser Asp Val Pro Ile Arg His
                165                 170                 175     
Ser Arg Lys Met Arg Lys Leu Met Leu Asp Leu Asn Lys Ala Lys Ser
            180                 185                 190         
Met Gly Gln Arg Leu Ser Leu Ile Ser Lys Phe Arg Phe Asn Phe Leu
        195                 200                 205             
Ala Ser Glu Leu Pro Ala Val Ser Glu Phe Ser Thr Ser Glu Thr Met
    210                 215                 220                 
Gly His Ser Ala Asp Arg Leu Ala Ala Ala Phe Ala Val Ser Arg Leu
225                 230                 235                 240 
Glu Gln Asp Glu Tyr Ala Leu Arg Ser His Ser Leu Ala Lys Lys Ala
                245                 250                 255     
Gln Asp Glu Gly Leu Leu Ser Asp Val Val Pro Phe Lys Val Pro Gly
            260                 265                 270         
Lys Asp Thr Val Thr Lys Asp Asn Gly Ile Arg Pro Ser Ser Leu Glu
        275                 280                 285             
Gln Met Ala Lys Leu Lys Pro Ala Phe Ile Lys Pro Tyr Gly Thr Val
    290                 295                 300                 
Thr Ala Ala Asn Ser Ser Phe Leu Thr Asp Gly Ala Ser Ala Met Leu
305                 310                 315                 320 
Ile Met Ala Glu Glu Lys Ala Leu Ala Met Gly Tyr Lys Pro Lys Ala
                325                 330                 335     
Tyr Leu Arg Asp Phe Met Tyr Val Ser Gln Asp Pro Lys Asp Gln Leu
            340                 345                 350         
Leu Leu Gly Pro Thr Tyr Ala Thr Pro Lys Val Leu Glu Lys Ala Gly
        355                 360                 365             
Leu Thr Met Asn Asp Ile Asp Ala Phe Glu Phe His Glu Ala Phe Ser
    370                 375                 380                 
Gly Gln Ile Leu Ala Asn Phe Lys Ala Met Asp Ser Asp Trp Phe Ala
385                 390                 395                 400 
Glu Asn Tyr Met Gly Arg Lys Thr Lys Val Gly Leu Pro Pro Leu Glu
                405                 410                 415     
Lys Phe Asn Asn Trp Gly Gly Ser Leu Ser Leu Gly His Pro Phe Gly
            420                 425                 430         
Ala Thr Gly Cys Arg Leu Val Met Ala Ala Ala Asn Arg Leu Arg Lys
        435                 440                 445             
Glu Gly Gly Gln Tyr Gly Leu Val Ala Ala Cys Ala Ala Gly Gly Gln
    450                 455                 460                 
Gly His Ala Met Ile Val Glu Ala Tyr Pro Lys
465                 470                 475 


<210> 2391
<211> 361
<212> PRT
<213> Homo sapiens

<400> 2391
Met Ala Thr Leu Ala Arg Leu Gln Ala Arg Ser Ser Thr Val Gly Asn
 1               5                  10                  15      
Gln Tyr Tyr Phe Arg Asn Ser Val Val Asp Pro Phe Arg Lys Lys Glu
            20                  25                  30          
Asn Asp Ala Ala Val Lys Ile Gln Ser Trp Phe Arg Gly Cys Gln Val
        35                  40                  45              
Arg Ala Tyr Ile Arg His Leu Asn Arg Ile Val Thr Ile Ile Gln Lys
    50                  55                  60                  
Trp Trp Arg Ser Phe Leu Gly Arg Lys Gln Tyr Gln Leu Thr Val Gln
65                  70                  75                  80  
Val Ala Tyr Tyr Thr Met Met Met Asn Leu Tyr Asn Ala Met Ala Val
                85                  90                  95      
Arg Ile Gln Arg Arg Trp Arg Gly Tyr Arg Val Arg Lys Tyr Leu Phe
            100                 105                 110         
Asn Tyr Tyr Tyr Leu Lys Glu Tyr Leu Lys Val Val Ser Glu Thr Asn
        115                 120                 125             
Asp Ala Ile Arg Lys Ala Leu Glu Glu Phe Ala Glu Met Lys Glu Arg
    130                 135                 140                 
Glu Glu Lys Lys Ala Asn Leu Glu Arg Glu Glu Lys Lys Arg Asp Tyr
145                 150                 155                 160 
Gln Ala Arg Lys Met His Tyr Leu Leu Ser Thr Lys Gln Ile Pro Gly
                165                 170                 175     
Ile Tyr Asn Ser Pro Phe Arg Lys Glu Pro Asp Pro Trp Glu Leu Gln
            180                 185                 190         
Leu Gln Lys Ala Lys Pro Leu Thr His Arg Arg Pro Lys Val Lys Gln
        195                 200                 205             
Lys Asp Ser Thr Ser Leu Thr Asp Trp Leu Ala Cys Thr Ser Ala Arg
    210                 215                 220                 
Ser Phe Pro Arg Ser Glu Ile Leu Pro Pro Ile Asn Arg Lys Gln Cys
225                 230                 235                 240 
Gln Gly Pro Phe Arg Asp Ile Thr Glu Val Leu Glu Gln Arg Tyr Arg
                245                 250                 255     
Pro Leu Glu Pro Thr Leu Arg Val Ala Glu Pro Ile Asp Glu Leu Lys
            260                 265                 270         
Leu Ala Arg Glu Glu Leu Arg Arg Glu Glu Trp Leu Gln Asn Val Asn
        275                 280                 285             
Asp Asn Met Phe Leu Pro Phe Ser Ser Tyr His Lys Asn Glu Lys Tyr
    290                 295                 300                 
Ile Pro Ser Met His Leu Ser Ser Lys Tyr Gly Pro Ile Ser Tyr Lys
305                 310                 315                 320 
Glu Gln Phe Arg Ser Glu Asn Pro Lys Lys Trp Ile Cys Asp Lys Asp
                325                 330                 335     
Phe Gln Thr Val Leu Pro Ser Phe Glu Leu Phe Ser Lys Tyr Gly Lys
            340                 345                 350         
Leu Tyr Ser Lys Ala Gly Gln Ile Val
        355                 360     


<210> 2392
<211> 355
<212> PRT
<213> Homo sapiens

<400> 2392
Met Gly Cys Thr Val Ser Ala Glu Asp Lys Ala Ala Ala Glu Arg Ser
 1               5                  10                  15      
Lys Met Ile Asp Lys Asn Leu Arg Glu Asp Gly Glu Lys Ala Ala Arg
            20                  25                  30          
Glu Val Lys Leu Leu Leu Leu Gly Ala Val Glu Ser Gly Lys Ser Thr
        35                  40                  45              
Ile Val Lys Gln Met Lys Ile Ile His Glu Asp Gly Tyr Ser Glu Glu
    50                  55                  60                  
Glu Cys Arg Gln Tyr Arg Ala Val Val Tyr Ser Asn Thr Ile Gln Ser
65                  70                  75                  80  
Ile Met Ala Ile Val Lys Ala Met Gly Asn Leu Gln Ile Asp Phe Ala
                85                  90                  95      
Asp Pro Ser Arg Ala Asp Asp Ala Arg Gln Leu Phe Ala Leu Ser Cys
            100                 105                 110         
Thr Ala Glu Glu Gln Gly Val Leu Pro Asp Asp Leu Ser Gly Val Ile
        115                 120                 125             
Arg Arg Leu Trp Ala Asp His Gly Val Gln Ala Cys Phe Gly Arg Ser
    130                 135                 140                 
Arg Glu Tyr Gln Leu Asn Asp Ser Ala Ala Tyr Tyr Leu Asn Asp Leu
145                 150                 155                 160 
Glu Arg Ile Ala Gln Ser Asp Tyr Ile Pro Thr Gln Gln Asp Val Leu
                165                 170                 175     
Arg Thr Arg Val Lys Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe
            180                 185                 190         
Lys Asp Leu His Phe Lys Met Phe Asp Val Gly Gly Gln Arg Ser Glu
        195                 200                 205             
Arg Lys Lys Trp Ile His Cys Phe Glu Gly Val Thr Ala Ile Ile Phe
    210                 215                 220                 
Cys Val Ala Leu Ser Ala Tyr Asp Leu Val Leu Ala Glu Asp Glu Glu
225                 230                 235                 240 
Met Asn Arg Met His Glu Ser Met Lys Leu Phe Asp Ser Ile Cys Asn
                245                 250                 255     
Asn Lys Trp Phe Thr Asp Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys
            260                 265                 270         
Asp Leu Phe Glu Glu Lys Ile Thr His Ser Pro Leu Thr Ile Cys Phe
        275                 280                 285             
Pro Glu Tyr Thr Gly Ala Asn Lys Tyr Asp Glu Ala Ala Ser Tyr Ile
    290                 295                 300                 
Gln Ser Lys Phe Glu Asp Leu Asn Lys Arg Lys Asp Thr Lys Glu Ile
305                 310                 315                 320 
Tyr Thr His Phe Thr Cys Ala Thr Asp Thr Lys Asn Val Gln Phe Val
                325                 330                 335     
Phe Asp Ala Val Thr Asp Val Ile Ile Lys Asn Asn Leu Lys Asp Cys
            340                 345                 350         
Gly Leu Phe
        355 


<210> 2393
<211> 780
<212> PRT
<213> Homo sapiens

<400> 2393
Met Thr Ala Ala Ala Ala Ser Asn Trp Gly Leu Ile Thr Asn Ile Val
 1               5                  10                  15      
Asn Ser Ile Val Gly Val Ser Val Leu Thr Met Pro Phe Cys Phe Lys
            20                  25                  30          
Gln Cys Gly Ile Val Leu Gly Ala Leu Leu Leu Val Phe Cys Ser Trp
        35                  40                  45              
Met Thr His Gln Ser Cys Met Phe Leu Val Lys Ser Ala Ser Leu Ser
    50                  55                  60                  
Lys Arg Arg Thr Tyr Ala Gly Leu Ala Phe His Ala Tyr Gly Lys Ala
65                  70                  75                  80  
Gly Lys Met Leu Val Glu Thr Ser Met Ile Gly Leu Met Leu Gly Thr
                85                  90                  95      
Cys Ile Ala Phe Tyr Val Val Ile Gly Asp Leu Gly Ser Asn Phe Phe
            100                 105                 110         
Ala Arg Leu Phe Gly Phe Gln Val Gly Gly Thr Phe Arg Met Phe Leu
        115                 120                 125             
Leu Phe Ala Val Ser Leu Cys Ile Val Leu Pro Leu Ser Leu Gln Arg
    130                 135                 140                 
Asn Met Met Ala Ser Ile Gln Ser Phe Ser Ala Met Ala Leu Leu Phe
145                 150                 155                 160 
Tyr Thr Val Phe Met Phe Val Ile Val Leu Ser Ser Leu Lys His Gly
                165                 170                 175     
Leu Phe Ser Gly Gln Trp Leu Arg Arg Val Ser Tyr Val Arg Trp Glu
            180                 185                 190         
Gly Val Phe Arg Cys Ile Pro Ile Phe Gly Met Ser Phe Ala Cys Gln
        195                 200                 205             
Ser Gln Val Leu Pro Thr Tyr Asp Ser Leu Asp Glu Pro Ser Val Lys
    210                 215                 220                 
Thr Met Ser Ser Ile Phe Ala Ser Ser Leu Asn Val Val Thr Thr Phe
225                 230                 235                 240 
Tyr Val Met Val Gly Phe Phe Gly Tyr Val Ser Phe Thr Glu Ala Thr
                245                 250                 255     
Ala Gly Asn Val Leu Met His Phe Pro Ser Asn Leu Val Thr Glu Met
            260                 265                 270         
Leu Arg Val Gly Phe Met Met Ser Val Ala Val Gly Phe Pro Met Met
        275                 280                 285             
Ile Leu Pro Cys Arg Gln Ala Leu Ser Thr Leu Leu Cys Glu Gln Gln
    290                 295                 300                 
Gln Lys Asp Gly Thr Phe Ala Ala Gly Gly Tyr Met Pro Pro Leu Arg
305                 310                 315                 320 
Phe Lys Ala Leu Thr Leu Ser Val Val Phe Gly Thr Met Val Gly Gly
                325                 330                 335     
Ile Leu Ile Pro Asn Val Glu Thr Ile Leu Gly Leu Thr Gly Ala Thr
            340                 345                 350         
Met Gly Ser Leu Ile Cys Phe Ile Cys Pro Ala Leu Ile Tyr Lys Lys
        355                 360                 365             
Ile His Lys Asn Ala Leu Ser Ser Gln Val Val Leu Trp Val Gly Leu
    370                 375                 380                 
Gly Val Leu Val Val Ser Thr Val Thr Thr Leu Ser Val Ser Glu Glu
385                 390                 395                 400 
Val Pro Glu Asp Leu Ala Glu Glu Ala Pro Gly Gly Arg Leu Gly Glu
                405                 410                 415     
Ala Glu Gly Leu Met Lys Val Glu Ala Ala Arg Leu Ser Ala Gln Asp
            420                 425                 430         
Pro Val Val Ala Val Ala Glu Asp Gly Arg Glu Lys Pro Lys Leu Pro
        435                 440                 445             
Lys Glu Arg Glu Glu Leu Glu Gln Ala Gln Ile Lys Gly Pro Val Asp
    450                 455                 460                 
Val Pro Gly Arg Glu Asp Gly Lys Glu Ala Pro Glu Glu Ala Gln Leu
465                 470                 475                 480 
Asp Arg Pro Gly Gln Gly Ile Ala Val Pro Val Gly Glu Ala His Arg
                485                 490                 495     
His Glu Pro Pro Val Pro His Asp Lys Val Val Val Asp Glu Gly Gln
            500                 505                 510         
Asp Arg Glu Val Pro Glu Glu Asn Lys Pro Pro Ser Arg His Ala Gly
        515                 520                 525             
Gly Lys Ala Pro Gly Val Gln Gly Gln Met Ala Pro Pro Leu Pro Asp
    530                 535                 540                 
Ser Glu Arg Glu Lys Gln Glu Pro Glu Gln Gly Glu Val Gly Lys Arg
545                 550                 555                 560 
Pro Gly Gln Ala Gln Ala Leu Glu Glu Ala Gly Asp Leu Pro Glu Asp
                565                 570                 575     
Pro Gln Lys Val Pro Glu Ala Asp Gly Gln Pro Ala Val Gln Pro Ala
            580                 585                 590         
Lys Glu Asp Leu Gly Pro Gly Asp Arg Gly Leu His Pro Arg Pro Gln
        595                 600                 605             
Ala Val Leu Ser Glu Gln Gln Asn Gly Leu Ala Val Gly Gly Gly Glu
    610                 615                 620                 
Lys Ala Lys Gly Gly Pro Pro Pro Gly Asn Ala Ala Gly Asp Thr Gly
625                 630                 635                 640 
Gln Pro Ala Glu Asp Ser Asp His Gly Gly Lys Pro Pro Leu Pro Ala
                645                 650                 655     
Glu Lys Pro Ala Pro Gly Pro Gly Leu Pro Pro Glu Pro Arg Glu Gln
            660                 665                 670         
Arg Asp Val Glu Arg Ala Gly Gly Asn Gln Ala Ala Ser Gln Leu Glu
        675                 680                 685             
Gly Lys Ala Ser Ala Leu Gln Pro Pro Ala Ser Gly Pro Gly Ser Gly
    690                 695                 700                 
Ser Pro Leu Pro Gln Pro Trp Gly Asp Ala Gln Val Ile Leu Gly Ser
705                 710                 715                 720 
Pro Ala Arg Pro Pro Phe Ser Phe Gln Pro Pro Ala Glu Gln Thr Pro
                725                 730                 735     
Arg Arg Ala Phe Cys Ser Leu Pro Ile Ser Ser Leu Leu Ser Gly Asn
            740                 745                 750         
Leu Leu Ser Ala Leu Leu Pro Phe Lys His Leu Arg His Arg His Met
        755                 760                 765             
Ala Cys Asp Tyr Arg Phe Ile Ser Leu Ala Pro Leu
    770                 775                 780 


<210> 2394
<211> 81
<212> PRT
<213> Homo sapiens

<400> 2394
Met Ser Asn Arg Leu Leu Cys Cys Val Ile Ile Cys Leu Leu Arg Ala
 1               5                  10                  15      
Gly Leu Lys Asp Ala Val Val Thr Gln Phe Pro Arg His Arg Ile Ile
            20                  25                  30          
Gly Thr Gly Lys Glu Phe Ile Leu Leu Cys Pro Gln Asn Met Asn His
        35                  40                  45              
Val Ala Met Tyr Trp Tyr Arg Gln Asn Pro Gly Leu Gly Leu Lys Leu
    50                  55                  60                  
Val Tyr Tyr Ser Pro Gly Thr Gly Ser Ile Glu Lys Gly Asp Val Ser
65                  70                  75                  80  
Glu
    


<210> 2395
<211> 188
<212> PRT
<213> Homo sapiens

<400> 2395
Phe Thr Thr Gly Cys His Tyr Trp Glu Val Tyr Val Gly Asp Lys Thr
 1               5                  10                  15      
Lys Trp Ile Leu Gly Val Cys Ser Glu Ser Val Ser Arg Lys Gly Lys
            20                  25                  30          
Val Thr Ala Ser Pro Ala Asn Gly His Trp Leu Leu Arg Gln Ser Arg
        35                  40                  45              
Gly Asn Glu Tyr Glu Ala Leu Thr Ser Pro Gln Thr Ser Phe Arg Leu
    50                  55                  60                  
Lys Glu Pro Pro Arg Cys Val Gly Ile Phe Leu Asp Tyr Glu Ala Gly
65                  70                  75                  80  
Val Ile Ser Phe Tyr Asn Val Thr Asn Lys Ser His Ile Phe Thr Phe
                85                  90                  95      
Thr His Asn Phe Ser Gly Pro Leu Arg Pro Phe Phe Glu Pro Cys Leu
            100                 105                 110         
His Asp Gly Gly Lys Asn Thr Ala Pro Leu Val Ile Cys Ser Glu Leu
        115                 120                 125             
His Lys Ser Glu Glu Ser Ile Val Pro Arg Pro Glu Gly Lys Gly His
    130                 135                 140                 
Ala Asn Gly Asp Val Ser Leu Lys Val Asn Ser Ser Leu Leu Pro Pro
145                 150                 155                 160 
Lys Ala Pro Glu Leu Lys Asp Ile Ile Leu Ser Leu Pro Pro Asp Leu
                165                 170                 175     
Gly Pro Ala Leu Gln Glu Leu Lys Ala Pro Ser Phe
            180                 185             


<210> 2396
<211> 88
<212> PRT
<213> Homo sapiens

<400> 2396
Met Ala Ser Val Val Pro Val Lys Asp Lys Lys Leu Leu Glu Val Lys
 1               5                  10                  15      
Leu Gly Glu Leu Pro Ser Trp Ile Leu Met Arg Asp Phe Ser Pro Ser
            20                  25                  30          
Gly Ile Phe Gly Ala Phe Gln Arg Gly Tyr Tyr Arg Tyr Tyr Asn Lys
        35                  40                  45              
Tyr Ile Asn Val Lys Lys Gly Ser Ile Ser Gly Ile Thr Met Val Leu
    50                  55                  60                  
Ala Cys Tyr Val Leu Phe Ser Tyr Ser Phe Ser Tyr Lys His Leu Lys
65                  70                  75                  80  
His Glu Arg Leu Arg Lys Tyr His
                85              


<210> 2397
<211> 161
<212> PRT
<213> Homo sapiens

<400> 2397
Ala Pro Ile Lys Val Gly Asp Ala Ile Pro Ala Val Glu Val Phe Glu
 1               5                  10                  15      
Gly Glu Pro Gly Asn Lys Val Asn Leu Ala Glu Leu Phe Lys Gly Lys
            20                  25                  30          
Lys Gly Val Leu Phe Gly Val Pro Gly Ala Phe Thr Pro Gly Cys Ser
        35                  40                  45              
Lys Thr His Leu Pro Gly Phe Val Glu Gln Ala Glu Ala Leu Lys Ala
    50                  55                  60                  
Lys Gly Val Gln Val Val Ala Cys Leu Ser Val Asn Asp Ala Phe Val
65                  70                  75                  80  
Thr Gly Glu Trp Gly Arg Ala His Lys Ala Glu Gly Lys Val Arg Leu
                85                  90                  95      
Leu Ala Asp Pro Thr Gly Ala Phe Gly Lys Glu Thr Asp Leu Leu Leu
            100                 105                 110         
Asp Asp Ser Leu Val Ser Ile Phe Gly Asn Arg Arg Leu Lys Arg Phe
        115                 120                 125             
Ser Met Val Val Gln Asp Gly Ile Val Lys Ala Leu Asn Val Glu Pro
    130                 135                 140                 
Asp Gly Thr Gly Leu Thr Cys Ser Leu Ala Pro Asn Ile Ile Ser Gln
145                 150                 155                 160 
Leu
    


<210> 2398
<211> 298
<212> PRT
<213> Homo sapiens

<400> 2398
Met Thr Glu Gln Ala Ile Ser Phe Ala Lys Asp Phe Leu Ala Gly Gly
 1               5                  10                  15      
Ile Ala Ala Ala Ile Ser Lys Thr Ala Val Ala Pro Ile Glu Arg Val
            20                  25                  30          
Lys Leu Leu Leu Gln Val Gln His Ala Ser Lys Gln Ile Ala Ala Asp
        35                  40                  45              
Lys Gln Tyr Lys Gly Ile Val Asp Cys Ile Val Arg Ile Pro Lys Glu
    50                  55                  60                  
Gln Gly Val Leu Ser Phe Trp Arg Gly Asn Leu Ala Asn Val Ile Arg
65                  70                  75                  80  
Tyr Phe Pro Thr Gln Ala Leu Asn Phe Ala Phe Lys Asp Lys Tyr Lys
                85                  90                  95      
Gln Ile Phe Leu Gly Gly Val Asp Lys His Thr Gln Phe Trp Arg Tyr
            100                 105                 110         
Phe Ala Gly Asn Leu Ala Ser Gly Gly Ala Ala Gly Ala Thr Ser Leu
        115                 120                 125             
Cys Phe Val Tyr Pro Leu Asp Phe Ala Arg Thr Arg Leu Ala Ala Asp
    130                 135                 140                 
Val Gly Lys Ser Gly Thr Glu Arg Glu Phe Arg Gly Leu Gly Asp Cys
145                 150                 155                 160 
Leu Val Lys Ile Thr Lys Ser Asp Gly Ile Arg Gly Leu Tyr Gln Gly
                165                 170                 175     
Phe Ser Val Ser Val Gln Gly Ile Ile Ile Tyr Arg Ala Ala Tyr Phe
            180                 185                 190         
Gly Val Tyr Asp Thr Ala Lys Gly Met Leu Pro Asp Pro Lys Asn Thr
        195                 200                 205             
His Ile Val Val Ser Trp Met Ile Ala Gln Thr Val Thr Ala Val Ala
    210                 215                 220                 
Gly Val Val Ser Tyr Pro Phe Asp Thr Val Arg Arg Arg Met Met Met
225                 230                 235                 240 
Gln Phe Gly Arg Lys Gly Ala Asp Ile Met Tyr Thr Gly Thr Val Asp
                245                 250                 255     
Cys Trp Arg Lys Ile Phe Arg Asp Glu Gly Gly Lys Ala Phe Phe Lys
            260                 265                 270         
Gly Ala Trp Ser Asn Val Leu Arg Gly Met Gly Gly Ala Phe Val Leu
        275                 280                 285             
Val Leu Tyr Asp Glu Leu Lys Lys Val Ile
    290                 295             


<210> 2399
<211> 631
<212> PRT
<213> Homo sapiens

<400> 2399
Met Ala Ala His Leu Val Lys Arg Cys Thr Cys Leu Leu Arg Glu Ala
 1               5                  10                  15      
Ala Arg Gln Ala Pro Ala Met Ala Pro Val Gly Arg Leu Arg Leu Ala
            20                  25                  30          
Trp Val Ala His Lys Thr Leu Thr Ser Ser Ala Thr Ser Pro Ile Ser
        35                  40                  45              
His Leu Pro Gly Ser Leu Met Glu Pro Val Glu Lys Glu Arg Ala Ser
    50                  55                  60                  
Thr Pro Tyr Ile Glu Lys Gln Val Asp His Leu Ile Lys Lys Ala Thr
65                  70                  75                  80  
Arg Pro Glu Glu Leu Leu Glu Leu Leu Gly Gly Ser His Asp Leu Asp
                85                  90                  95      
Ser Asn Gln Ala Ala Met Val Leu Ile Arg Leu Ser His Leu Leu Ser
            100                 105                 110         
Glu Lys Pro Glu Asp Lys Gly Leu Leu Ile Gln Asp Ala His Phe His
        115                 120                 125             
Gln Leu Leu Cys Leu Leu Asn Ser Gln Ile Ala Ser Val Trp His Gly
    130                 135                 140                 
Thr Leu Ser Lys Leu Leu Gly Ser Leu Tyr Ala Leu Gly Ile Pro Lys
145                 150                 155                 160 
Ala Ser Lys Glu Leu Gln Ser Val Glu Gln Glu Val Arg Trp Arg Met
                165                 170                 175     
Arg Lys Leu Lys Tyr Lys His Leu Ala Phe Leu Ala Glu Ser Cys Ala
            180                 185                 190         
Thr Leu Ser Gln Glu Gln His Ser Gln Glu Leu Leu Ala Glu Leu Leu
        195                 200                 205             
Thr His Leu Glu Arg Arg Trp Thr Glu Ile Glu Asp Ser His Thr Leu
    210                 215                 220                 
Val Thr Val Met Met Lys Val Gly His Leu Ser Glu Pro Leu Met Asn
225                 230                 235                 240 
Arg Leu Glu Asp Lys Cys Leu Glu Leu Val Glu His Phe Gly Pro Asn
                245                 250                 255     
Glu Leu Arg Lys Val Leu Val Met Leu Ala Ala Gln Ser Arg Arg Ser
            260                 265                 270         
Val Pro Leu Leu Arg Ala Ile Ser Tyr His Leu Val Gln Lys Pro Phe
        275                 280                 285             
Ser Leu Thr Lys Asp Val Leu Leu Asp Val Ala Tyr Ala Tyr Gly Lys
    290                 295                 300                 
Leu Ser Phe His Gln Thr Gln Val Ser Gln Arg Leu Ala Thr Asp Leu
305                 310                 315                 320 
Leu Ser Leu Met Pro Ser Leu Thr Ser Gly Glu Val Ala His Cys Ala
                325                 330                 335     
Lys Ser Phe Ala Leu Leu Lys Trp Leu Ser Leu Pro Leu Phe Glu Ala
            340                 345                 350         
Phe Ala Gln His Val Leu Asn Arg Ala Gln Asp Ile Thr Leu Pro His
        355                 360                 365             
Leu Cys Ser Val Leu Leu Ala Phe Ala Arg Leu Asn Phe His Pro Asp
    370                 375                 380                 
Gln Glu Asp Gln Phe Phe Ser Leu Val His Glu Lys Leu Gly Ser Glu
385                 390                 395                 400 
Leu Pro Gly Leu Glu Pro Ala Leu Gln Val Asp Leu Val Trp Ala Leu
                405                 410                 415     
Cys Val Leu Gln Gln Ala Arg Glu Ala Glu Leu Gln Ala Val Leu His
            420                 425                 430         
Pro Glu Phe His Ile Gln Phe Leu Gly Gly Lys Ser Gln Lys Asp Gln
        435                 440                 445             
Asn Thr Phe Gln Lys Leu Leu His Ile Asn Ala Thr Ala Leu Leu Glu
    450                 455                 460                 
Tyr Pro Glu Tyr Ser Gly Pro Leu Leu Pro Ala Ser Ala Val Ala Pro
465                 470                 475                 480 
Gly Pro Ser Ala Leu Asp Arg Lys Val Thr Pro Leu Gln Lys Glu Leu
                485                 490                 495     
Gln Glu Thr Leu Lys Gly Leu Leu Gly Ser Ala Asp Lys Gly Ser Leu
            500                 505                 510         
Glu Val Ala Thr Gln Tyr Gly Trp Val Leu Asp Ala Glu Val Leu Leu
        515                 520                 525             
Asp Ser Asp Gly Glu Phe Leu Pro Val Arg Asp Phe Val Ala Pro His
    530                 535                 540                 
Leu Ala Gln Pro Thr Gly Ser Gln Ser Pro Pro Pro Gly Ser Lys Arg
545                 550                 555                 560 
Leu Ala Phe Leu Arg Trp Glu Phe Pro Asn Phe Asn Ser Arg Ser Lys
                565                 570                 575     
Asp Leu Leu Gly Arg Phe Val Leu Ala Arg Arg His Ile Val Ala Ala
            580                 585                 590         
Gly Phe Leu Ile Val Asp Val Pro Phe Tyr Glu Trp Leu Glu Leu Lys
        595                 600                 605             
Ser Glu Trp Gln Lys Gly Ala Tyr Leu Lys Asp Lys Met Arg Lys Ala
    610                 615                 620                 
Val Ala Glu Glu Leu Ala Lys
625                 630     


<210> 2400
<211> 454
<212> PRT
<213> Homo sapiens

<400> 2400
Met Ala Glu Phe Ser Gln Lys Arg Gly Lys Arg Arg Ser Asp Glu Gly
 1               5                  10                  15      
Leu Gly Ser Met Val Asp Phe Leu Leu Ala Asn Ala Arg Leu Val Leu
            20                  25                  30          
Gly Val Gly Gly Ala Ala Val Leu Gly Ile Ala Thr Leu Ala Val Lys
        35                  40                  45              
Arg Phe Ile Asp Arg Ala Thr Ser Pro Arg Asp Glu Asp Asp Thr Lys
    50                  55                  60                  
Ala Asp Ser Trp Lys Glu Leu Ser Leu Leu Lys Ala Thr Pro His Leu
65                  70                  75                  80  
Gln Pro Arg Pro Pro Pro Ala Ala Leu Ser Gln Pro Val Leu Pro Leu
                85                  90                  95      
Ala Pro Ser Ser Ser Ala Pro Glu Gly Pro Ala Glu Thr Asp Pro Glu
            100                 105                 110         
Val Thr Pro Gln Leu Ser Ser Pro Ala Pro Leu Cys Leu Thr Leu Gln
        115                 120                 125             
Glu Arg Leu Leu Ala Phe Glu Arg Asp Arg Val Thr Ile Pro Ala Ala
    130                 135                 140                 
Gln Val Ala Leu Ala Lys Gln Leu Ala Gly Asp Ile Ala Leu Glu Leu
145                 150                 155                 160 
Gln Ala Tyr Phe Arg Ser Lys Phe Pro Glu Leu Pro Phe Gly Ala Phe
                165                 170                 175     
Val Pro Gly Gly Pro Leu Tyr Asp Gly Leu Gln Ala Gly Ala Ala Asp
            180                 185                 190         
His Val Arg Leu Leu Val Pro Leu Val Leu Glu Pro Gly Leu Trp Ser
        195                 200                 205             
Leu Val Pro Gly Val Asp Thr Val Ala Arg Asp Pro Arg Cys Trp Ala
    210                 215                 220                 
Val Arg Arg Thr Gln Leu Glu Phe Cys Pro Arg Gly Ser Ser Pro Trp
225                 230                 235                 240 
Asp Arg Phe Leu Val Gly Gly Tyr Leu Ser Ser Arg Val Leu Leu Glu
                245                 250                 255     
Leu Leu Arg Lys Ala Leu Ala Ala Ser Val Asn Trp Pro Ala Ile Gly
            260                 265                 270         
Ser Leu Leu Gly Cys Leu Ile Arg Pro Ser Met Ala Ser Glu Glu Leu
        275                 280                 285             
Leu Leu Glu Val Gln His Glu Arg Leu Glu Leu Thr Val Ala Val Leu
    290                 295                 300                 
Val Ala Val Pro Gly Val Asp Ala Asp Asp Arg Leu Leu Leu Ala Trp
305                 310                 315                 320 
Pro Leu Glu Gly Leu Ala Gly Asn Leu Trp Leu Gln Asp Leu Tyr Pro
                325                 330                 335     
Val Glu Ala Ala Arg Leu Arg Ala Leu Asp Asp His Asp Ala Gly Thr
            340                 345                 350         
Arg Arg Arg Leu Leu Leu Leu Leu Cys Ala Val Cys Arg Gly Cys Ser
        355                 360                 365             
Ala Leu Gly Gln Leu Gly Arg Gly His Leu Thr Gln Val Val Leu Arg
    370                 375                 380                 
Leu Gly Glu Asp Asn Val Asp Trp Thr Glu Glu Ala Leu Gly Glu Arg
385                 390                 395                 400 
Phe Leu Gln Ala Leu Glu Leu Leu Ile Gly Ser Leu Glu Gln Ala Ser
                405                 410                 415     
Leu Pro Cys His Phe Asn Pro Ser Val Asn Leu Phe Ser Ser Leu Arg
            420                 425                 430         
Glu Glu Glu Ile Asp Asp Ile Gly Tyr Ala Leu Tyr Ser Gly Leu Gln
        435                 440                 445             
Glu Pro Glu Gly Leu Leu
    450                 


<210> 2401
<211> 303
<212> PRT
<213> Homo sapiens

<400> 2401
Met Val Tyr Gln Thr Ser Leu Cys Ser Cys Ser Val Asn Ile Arg Val
 1               5                  10                  15      
Pro Asn Arg His Phe Ala Ala Ala Lys Lys Ser Ala Lys Lys Thr Lys
            20                  25                  30          
Lys Gly Ala Lys Glu Lys Thr Pro Asp Glu Lys Lys Asp Glu Ile Glu
        35                  40                  45              
Lys Ile Lys Ala Tyr Pro Tyr Met Glu Gly Glu Pro Glu Asp Asp Val
    50                  55                  60                  
Tyr Leu Lys Arg Leu Tyr Pro Arg Gln Ile Tyr Glu Val Glu Lys Ala
65                  70                  75                  80  
Val His Leu Leu Lys Lys Phe Gln Ile Leu Asp Phe Thr Ser Pro Lys
                85                  90                  95      
Gln Ser Val Tyr Leu Asp Leu Thr Leu Asp Met Ala Leu Gly Lys Lys
            100                 105                 110         
Lys Asn Val Glu Pro Phe Thr Ser Val Leu Ser Leu Pro Tyr Pro Phe
        115                 120                 125             
Ala Ser Glu Ile Asn Lys Val Ala Val Phe Thr Glu Asn Ala Ser Glu
    130                 135                 140                 
Val Lys Ile Ala Glu Glu Asn Gly Ala Ala Ser Ala Gly Gly Thr Ser
145                 150                 155                 160 
Leu Ile Gln Lys Ile Trp Asp Asp Glu Ile Val Ala Asp Phe Tyr Val
                165                 170                 175     
Ala Val Pro Glu Ile Met Pro Glu Leu Asn Arg Leu Arg Lys Lys Leu
            180                 185                 190         
Asn Lys Lys Tyr Pro Lys Leu Ser Arg Asn Ser Ile Gly Arg Asp Ile
        195                 200                 205             
Pro Lys Met Leu Glu Leu Phe Lys Asn Gly His Glu Ile Lys Val Asp
    210                 215                 220                 
Glu Glu Arg Glu Asn Phe Leu Gln Thr Lys Ile Ala Thr Leu Asp Met
225                 230                 235                 240 
Ser Ser Asp Gln Ile Ala Ala Asn Leu Gln Ala Val Ile Asn Glu Val
                245                 250                 255     
Cys Arg His Arg Pro Leu Asn Leu Gly Pro Phe Val Val Arg Ala Phe
            260                 265                 270         
Leu Arg Ser Ser Thr Ser Glu Gly Leu Leu Leu Lys Ile Asp Pro Leu
        275                 280                 285             
Leu Pro Lys Glu Val Lys Asn Glu Glu Ser Glu Lys Glu Asp Ala
    290                 295                 300             


<210> 2402
<211> 260
<212> PRT
<213> Homo sapiens

<400> 2402
Met Asn Asn Leu Asn Asp Pro Pro Asn Trp Asn Ile Arg Pro Asn Ser
 1               5                  10                  15      
Arg Ala Asp Gly Gly Asp Gly Ser Arg Trp Asn Tyr Ala Leu Leu Val
            20                  25                  30          
Pro Met Leu Gly Leu Ala Ala Phe Arg Trp Ile Trp Ser Arg Glu Ser
        35                  40                  45              
Gln Lys Glu Val Glu Lys Glu Arg Glu Ala Tyr Arg Arg Arg Thr Ala
    50                  55                  60                  
Ala Phe Gln Gln Asp Leu Glu Ala Lys Tyr His Ala Met Ile Ser Glu
65                  70                  75                  80  
Asn Arg Arg Ala Val Ala Gln Leu Ser Leu Glu Leu Glu Lys Glu Gln
                85                  90                  95      
Asn Arg Thr Ala Ser Tyr Arg Glu Ala Leu Ile Ser Gln Gly Arg Lys
            100                 105                 110         
Leu Val Glu Glu Lys Lys Leu Leu Glu Gln Glu Arg Ala Gln Val Met
        115                 120                 125             
Gln Glu Lys Arg Gln Val Gln Pro Leu Arg Ser Ala Tyr Leu Ser Cys
    130                 135                 140                 
Leu Gln Arg Glu Glu Asn Trp Gln Arg Arg Ala Arg Leu Leu Leu Lys
145                 150                 155                 160 
Glu Phe Glu Ala Val Leu Thr Glu Arg Gln Asn Ile Tyr Cys Ser Leu
                165                 170                 175     
Phe Leu Pro Arg Ser Lys Arg Leu Glu Ile Glu Lys Ser Leu Leu Val
            180                 185                 190         
Arg Ala Ser Val Asp Pro Val Ala Ala Asp Leu Glu Met Ala Ala Gly
        195                 200                 205             
Leu Thr Asp Ile Phe Gln His Asp Thr Tyr Cys Gly Asp Val Trp Asn
    210                 215                 220                 
Thr Asn Lys Arg Gln Asn Gly Arg Leu Met Trp Leu Tyr Leu Lys Tyr
225                 230                 235                 240 
Trp Glu Leu Val Val Glu Leu Lys Lys Phe Lys Arg Val Glu Glu Ala
                245                 250                 255     
Ile Leu Glu Lys
            260 


<210> 2403
<211> 492
<212> PRT
<213> Homo sapiens

<400> 2403
Pro Arg Val Arg Pro Arg Val Arg Pro Arg Val Arg His Gln Gly Thr
 1               5                  10                  15      
Gly Ala Gly Ile Ser Pro Val Ile Leu Asn Ser Gly Glu Gly Lys Glu
            20                  25                  30          
Val Asp Ile Leu Arg Met Leu Ile Lys Ala Lys Asp Glu Tyr Thr Lys
        35                  40                  45              
Cys Lys Thr Cys Ser Glu Pro Lys Lys Ile Thr Ser Ser Ser Ala Ile
    50                  55                  60                  
Tyr Asp Asn Pro Asn Leu Ile Lys Pro Ile Pro Val Lys Pro Ser Glu
65                  70                  75                  80  
Asn Gln Gln Gln Arg Ile Pro Gln Pro Asn Gln Thr Leu Asp Pro Glu
                85                  90                  95      
Pro Gln His Leu Ser Leu Thr Ala Leu Phe Gly Lys Gln Asp Lys Ala
            100                 105                 110         
Thr Cys Gln Glu Thr Val Glu Pro Pro Gln Thr Leu His Gln Gln Gln
        115                 120                 125             
Gln Gln Gln Gln Gln Gln Gln Gln Glu Lys Leu Pro Ile Arg Gln Gly
    130                 135                 140                 
Val Val Arg Ser Leu Ser Tyr Glu Glu Pro Arg Arg His Ser Pro Pro
145                 150                 155                 160 
Ile Glu Lys Gln Leu Cys Pro Ala Ile Gln Lys Leu Met Val Arg Ser
                165                 170                 175     
Ala Asp Leu His Pro Leu Ser Glu Leu Pro Glu Asn Arg Pro Cys Glu
            180                 185                 190         
Asn Gly Ser Thr His Ser Ala Gly Glu Phe Phe Thr Gly Pro Val Gln
        195                 200                 205             
Pro Gly Ser Pro His Asn Ile Gly Thr Ser Arg Gly Val Gln Asn Ala
    210                 215                 220                 
Ser Arg Thr Gln Asn Leu Phe Glu Lys Leu Gln Ser Thr Pro Gly Ala
225                 230                 235                 240 
Ala Asn Lys Cys Asp Pro Ser Thr Pro Ala Pro Ala Ser Ser Ala Ala
                245                 250                 255     
Leu Asn Arg Ser Arg Ala Pro Thr Ser Val Thr Pro Val Ala Pro Gly
            260                 265                 270         
Lys Gly Leu Ala Gln Pro Pro Gln Ala Tyr Phe Asn Gly Ser Leu Pro
        275                 280                 285             
Pro Gln Thr Val Gly His Gln Ala His Gly Arg Glu Gln Ser Thr Leu
    290                 295                 300                 
Pro Arg Gln Thr Leu Pro Ile Ser Gly Ser Gln Thr Gly Ser Ser Gly
305                 310                 315                 320 
Val Ile Ser Pro Gln Glu Leu Leu Lys Lys Leu Gln Ile Val Gln Gln
                325                 330                 335     
Glu Gln Gln Leu His Ala Ser Asn Arg Pro Ala Leu Ala Ala Lys Phe
            340                 345                 350         
Pro Val Leu Ala Gln Ser Ser Gly Thr Gly Lys Pro Leu Glu Ser Trp
        355                 360                 365             
Ile Asn Lys Thr Pro Asn Thr Glu Gln Gln Thr Pro Leu Phe Gln Val
    370                 375                 380                 
Ile Ser Pro Gln Arg Ile Pro Ala Thr Ala Ala Pro Ser Leu Leu Met
385                 390                 395                 400 
Ser Pro Met Val Phe Ala Gln Pro Thr Ser Val Pro Pro Lys Glu Arg
                405                 410                 415     
Glu Ser Gly Leu Leu Pro Val Gly Gly Gln Glu Pro Pro Ala Ala Ala
            420                 425                 430         
Thr Ser Leu Leu Leu Pro Ile Gln Ser Pro Glu Pro Ser Val Ile Thr
        435                 440                 445             
Ser Ser Pro Leu Thr Lys Leu Gln Leu Gln Glu Ala Leu Leu Tyr Leu
    450                 455                 460                 
Ile Gln Asn Asp Asp Asn Phe Leu Asn Ile Ile Tyr Glu Ala Tyr Leu
465                 470                 475                 480 
Phe Ser Met Thr Gln Ala Ala Met Lys Lys Thr Met
                485                 490         


<210> 2404
<211> 59
<212> PRT
<213> Homo sapiens

<400> 2404
Gly Arg Ile Ala Phe Thr Asp Ala Asp Asp Val Ala Ile Leu Thr Tyr
 1               5                  10                  15      
Val Lys Glu Asn Ala Arg Ser Pro Ser Ser Val Thr Gly Asn Ala Leu
            20                  25                  30          
Trp Lys Ala Met Glu Lys Ser Ser Leu Thr Gln His Ser Trp Gln Ser
        35                  40                  45              
Leu Lys Asp Arg Tyr Leu Lys His Leu Arg Gly
    50                  55                  


<210> 2405
<211> 130
<212> PRT
<213> Homo sapiens

<400> 2405
Lys Val Phe Glu Arg Cys Glu Leu Ala Arg Thr Leu Lys Arg Leu Gly
 1               5                  10                  15      
Met Asp Gly Tyr Arg Gly Ile Ser Leu Ala Asn Trp Met Cys Leu Ala
            20                  25                  30          
Lys Trp Glu Ser Gly Tyr Asn Thr Arg Ala Thr Asn Tyr Asn Ala Gly
        35                  40                  45              
Asp Arg Ser Thr Asp Tyr Gly Ile Phe Gln Ile Asn Ser Arg Tyr Trp
    50                  55                  60                  
Cys Asn Asp Gly Lys Thr Pro Gly Ala Val Asn Ala Cys His Leu Ser
65                  70                  75                  80  
Cys Ser Ala Leu Leu Gln Asp Asn Ile Ala Asp Ala Val Ala Cys Ala
                85                  90                  95      
Lys Arg Val Val Arg Asp Pro Gln Gly Ile Arg Ala Trp Val Ala Trp
            100                 105                 110         
Arg Asn Arg Cys Gln Asn Arg Asp Val Arg Gln Tyr Val Gln Gly Cys
        115                 120                 125             
Gly Val
    130 


<210> 2406
<211> 250
<212> PRT
<213> Homo sapiens

<400> 2406
Met Asn Asp Leu Arg Val Pro Phe Ile Arg Asp Asn Leu Leu Glu Thr
 1               5                  10                  15      
Ile Pro Asn His Gln Pro Gly Lys Pro Leu Leu Gly Met Lys Ile Leu
            20                  25                  30          
Asp Val Gly Cys Gly Gly Gly Leu Leu Thr Glu Pro Leu Gly Arg Leu
        35                  40                  45              
Gly Ala Ser Val Ile Gly Ile Asp Pro Val Asp Glu Asn Ile Lys Thr
    50                  55                  60                  
Ala Gln Cys His Lys Ser Phe Asp Pro Val Leu Asp Lys Arg Ile Glu
65                  70                  75                  80  
Tyr Arg Val Cys Ser Leu Glu Glu Ile Val Glu Glu Thr Ala Glu Thr
                85                  90                  95      
Phe Asp Ala Val Val Ala Ser Glu Val Val Glu His Val Ile Asp Leu
            100                 105                 110         
Glu Thr Phe Leu Gln Cys Cys Cys Gln Val Leu Lys Pro Gly Gly Ser
        115                 120                 125             
Leu Phe Ile Thr Thr Ile Asn Lys Thr Gln Leu Ser Tyr Ala Leu Gly
    130                 135                 140                 
Ile Val Phe Ser Glu Gln Ile Ala Gly Ile Val Pro Lys Gly Thr His
145                 150                 155                 160 
Thr Trp Glu Lys Phe Val Ser Pro Glu Thr Leu Glu Ser Ile Leu Glu
                165                 170                 175     
Ser Asn Gly Leu Ser Val Gln Thr Val Val Gly Met Leu Tyr Asn Pro
            180                 185                 190         
Phe Ser Gly Tyr Trp His Trp Ser Glu Asn Thr Ser Leu Asn Tyr Ala
        195                 200                 205             
Ala His Ala Val Lys Ser Arg Val Gln Glu His Pro Ala Ser Ala Glu
    210                 215                 220                 
Phe Val Leu Lys Gly Glu Thr Glu Glu Leu Gln Ala Asn Ala Cys Thr
225                 230                 235                 240 
Asn Pro Ala Val His Glu Lys Leu Lys Lys
                245                 250 


<210> 2407
<211> 916
<212> PRT
<213> Homo sapiens

<400> 2407
Met Asp Cys Glu His Ser Leu Ser Leu Pro Cys Arg Gly Ala Glu Ala
 1               5                  10                  15      
Trp Glu Ile Gly Ile Asp Lys Tyr Leu Tyr Ala Met Arg Leu Ser Asp
            20                  25                  30          
Glu Thr Leu Ile Asp Ile Met Thr Arg Phe Arg Lys Glu Met Lys Asn
        35                  40                  45              
Gly Leu Ser Arg Asp Phe Asn Pro Thr Ala Thr Val Lys Met Leu Pro
    50                  55                  60                  
Thr Phe Val Arg Ser Ile Pro Asp Gly Ser Glu Lys Gly Asp Phe Ile
65                  70                  75                  80  
Ala Leu Asp Leu Gly Gly Ser Ser Phe Arg Ile Leu Arg Val Gln Val
                85                  90                  95      
Asn His Glu Lys Asn Gln Asn Val His Met Glu Ser Glu Val Tyr Asp
            100                 105                 110         
Thr Pro Glu Asn Ile Val His Gly Ser Gly Ser Gln Leu Phe Asp His
        115                 120                 125             
Val Ala Glu Cys Leu Gly Asp Phe Met Glu Lys Arg Lys Ile Lys Asp
    130                 135                 140                 
Lys Lys Leu Pro Val Gly Phe Thr Phe Ser Phe Pro Cys Gln Gln Ser
145                 150                 155                 160 
Lys Ile Asp Glu Ala Ile Leu Ile Thr Trp Thr Lys Arg Phe Lys Ala
                165                 170                 175     
Ser Gly Val Glu Gly Ala Asp Val Val Lys Leu Leu Asn Lys Ala Ile
            180                 185                 190         
Lys Lys Arg Gly Asp Tyr Asp Ala Asn Ile Val Ala Val Val Asn Asp
        195                 200                 205             
Thr Val Gly Thr Met Met Thr Cys Gly Tyr Asp Asp Gln His Cys Glu
    210                 215                 220                 
Val Gly Leu Ile Ile Gly Thr Gly Thr Asn Ala Cys Tyr Met Glu Glu
225                 230                 235                 240 
Leu Arg His Ile Asp Leu Val Glu Gly Asp Glu Gly Arg Met Cys Ile
                245                 250                 255     
Asn Thr Glu Trp Gly Ala Phe Gly Asp Asp Gly Ser Leu Glu Asp Ile
            260                 265                 270         
Arg Thr Glu Phe Asp Arg Glu Ile Asp Arg Gly Ser Leu Asn Pro Gly
        275                 280                 285             
Lys Gln Leu Phe Glu Lys Met Val Ser Gly Met Tyr Leu Gly Glu Leu
    290                 295                 300                 
Val Arg Leu Ile Leu Val Lys Met Ala Lys Glu Gly Leu Leu Phe Glu
305                 310                 315                 320 
Gly Arg Ile Thr Pro Glu Leu Leu Thr Arg Gly Lys Phe Asn Thr Ser
                325                 330                 335     
Asp Val Ser Ala Ile Glu Lys Asn Lys Glu Gly Leu His Asn Ala Lys
            340                 345                 350         
Glu Ile Leu Thr Arg Leu Gly Val Glu Pro Ser Asp Asp Asp Cys Val
        355                 360                 365             
Ser Val Gln His Val Cys Thr Ile Val Ser Phe Arg Ser Ala Asn Leu
    370                 375                 380                 
Val Ala Ala Thr Leu Gly Ala Ile Leu Asn Arg Leu Arg Asp Asn Lys
385                 390                 395                 400 
Gly Thr Pro Arg Leu Arg Thr Thr Val Gly Val Asp Gly Ser Leu Tyr
                405                 410                 415     
Lys Thr His Pro Gln Tyr Ser Arg Arg Phe His Lys Thr Leu Arg Arg
            420                 425                 430         
Leu Val Pro Asp Ser Asp Val Arg Phe Leu Leu Ser Glu Ser Gly Ser
        435                 440                 445             
Gly Lys Gly Ala Ala Met Val Thr Ala Val Ala Tyr Arg Leu Ala Glu
    450                 455                 460                 
Gln His Arg Gln Ile Glu Glu Thr Leu Ala His Phe His Leu Thr Lys
465                 470                 475                 480 
Asp Met Leu Leu Glu Val Lys Lys Arg Met Arg Ala Glu Met Glu Leu
                485                 490                 495     
Gly Leu Arg Lys Gln Thr His Asn Asn Ala Val Val Lys Met Leu Pro
            500                 505                 510         
Ser Phe Val Arg Arg Thr Pro Asp Gly Thr Glu Asn Gly Asp Phe Leu
        515                 520                 525             
Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val Leu Leu Val Lys Ile
    530                 535                 540                 
Arg Ser Gly Lys Lys Arg Thr Val Glu Met His Asn Lys Ile Tyr Ala
545                 550                 555                 560 
Ile Pro Ile Glu Ile Met Gln Gly Thr Gly Glu Glu Leu Phe Asp His
                565                 570                 575     
Ile Val Ser Cys Ile Ser Asp Phe Leu Asp Tyr Met Gly Ile Lys Gly
            580                 585                 590         
Pro Arg Met Pro Leu Gly Phe Thr Phe Ser Phe Pro Cys Gln Gln Thr
        595                 600                 605             
Ser Leu Asp Ala Gly Ile Leu Ile Thr Trp Thr Lys Gly Phe Lys Ala
    610                 615                 620                 
Thr Asp Cys Val Gly His Asp Val Val Thr Leu Leu Arg Asp Ala Ile
625                 630                 635                 640 
Lys Arg Arg Glu Glu Phe Asp Leu Asp Val Val Ala Val Val Asn Asp
                645                 650                 655     
Thr Val Gly Thr Met Met Thr Cys Ala Tyr Glu Glu Pro Thr Cys Glu
            660                 665                 670         
Val Gly Leu Ile Val Gly Thr Gly Ser Asn Ala Cys Tyr Met Glu Glu
        675                 680                 685             
Met Lys Asn Val Glu Met Val Glu Gly Asp Gln Gly Gln Met Cys Ile
    690                 695                 700                 
Asn Met Glu Trp Gly Ala Phe Gly Asp Asn Gly Cys Leu Asp Asp Ile
705                 710                 715                 720 
Arg Thr His Tyr Asp Arg Leu Val Asp Glu Tyr Ser Leu Asn Ala Gly
                725                 730                 735     
Lys Gln Arg Tyr Glu Lys Met Ile Ser Gly Met Tyr Leu Gly Glu Ile
            740                 745                 750         
Val Arg Asn Ile Leu Ile Asp Phe Thr Lys Lys Gly Phe Leu Phe Arg
        755                 760                 765             
Gly Gln Ile Ser Glu Thr Leu Lys Thr Arg Gly Ile Phe Glu Thr Lys
    770                 775                 780                 
Phe Leu Ser Gln Ile Glu Ser Asp Arg Leu Ala Leu Leu Gln Val Arg
785                 790                 795                 800 
Ala Ile Leu Gln Gln Leu Gly Leu Asn Ser Thr Cys Asp Asp Ser Ile
                805                 810                 815     
Leu Val Lys Thr Val Cys Gly Val Val Ser Arg Arg Ala Ala Gln Leu
            820                 825                 830         
Cys Gly Ala Gly Met Ala Ala Val Val Asp Lys Ile Arg Glu Asn Arg
        835                 840                 845             
Gly Leu Asp Arg Leu Asn Val Thr Val Gly Val Asp Gly Thr Leu Tyr
    850                 855                 860                 
Lys Leu His Pro His Phe Ser Arg Ile Met His Gln Thr Val Lys Glu
865                 870                 875                 880 
Leu Ser Pro Lys Cys Asn Val Ser Phe Leu Leu Ser Glu Asp Gly Ser
                885                 890                 895     
Gly Lys Gly Ala Ala Leu Ile Thr Ala Val Gly Val Arg Leu Arg Thr
            900                 905                 910         
Glu Ala Ser Ser
        915     


<210> 2408
<211> 921
<212> PRT
<213> Homo sapiens

<400> 2408
Met Gly Gln Ile Cys Gln Arg Glu Ser Ala Thr Ala Ala Glu Lys Pro
 1               5                  10                  15      
Lys Leu His Leu Leu Ala Glu Ser Glu Ile Asp Lys Tyr Leu Tyr Ala
            20                  25                  30          
Met Arg Leu Ser Asp Glu Thr Leu Ile Asp Ile Met Thr Arg Phe Arg
        35                  40                  45              
Lys Glu Met Lys Asn Gly Leu Ser Arg Asp Phe Asn Pro Thr Ala Thr
    50                  55                  60                  
Val Lys Met Leu Pro Thr Phe Val Arg Ser Ile Pro Asp Gly Ser Glu
65                  70                  75                  80  
Lys Gly Asp Phe Ile Ala Leu Asp Leu Gly Gly Ser Ser Phe Arg Ile
                85                  90                  95      
Leu Arg Val Gln Val Asn His Glu Lys Asn Gln Asn Val His Met Glu
            100                 105                 110         
Ser Glu Val Tyr Asp Thr Pro Glu Asn Ile Val His Gly Ser Gly Ser
        115                 120                 125             
Gln Leu Phe Asp His Val Ala Glu Cys Leu Gly Asp Phe Met Glu Lys
    130                 135                 140                 
Arg Lys Ile Lys Asp Lys Lys Leu Pro Val Gly Phe Thr Phe Ser Phe
145                 150                 155                 160 
Pro Cys Gln Gln Ser Lys Ile Asp Glu Ala Ile Leu Ile Thr Trp Thr
                165                 170                 175     
Lys Arg Phe Lys Ala Ser Gly Val Glu Gly Ala Asp Val Val Lys Leu
            180                 185                 190         
Leu Asn Lys Ala Ile Lys Lys Arg Gly Asp Tyr Asp Ala Asn Ile Val
        195                 200                 205             
Ala Val Val Asn Asp Thr Val Gly Thr Met Met Thr Cys Gly Tyr Asp
    210                 215                 220                 
Asp Gln His Cys Glu Val Gly Leu Ile Ile Gly Thr Gly Thr Asn Ala
225                 230                 235                 240 
Cys Tyr Met Glu Glu Leu Arg His Ile Asp Leu Val Glu Gly Asp Glu
                245                 250                 255     
Gly Arg Met Cys Ile Asn Thr Glu Trp Gly Ala Phe Gly Asp Asp Gly
            260                 265                 270         
Ser Leu Glu Asp Ile Arg Thr Glu Phe Asp Arg Glu Ile Asp Arg Gly
        275                 280                 285             
Ser Leu Asn Pro Gly Lys Gln Leu Phe Glu Lys Met Val Ser Gly Met
    290                 295                 300                 
Tyr Leu Gly Glu Leu Val Arg Leu Ile Leu Val Lys Met Ala Lys Glu
305                 310                 315                 320 
Gly Leu Leu Phe Glu Gly Arg Ile Thr Pro Glu Leu Leu Thr Arg Gly
                325                 330                 335     
Lys Phe Asn Thr Ser Asp Val Ser Ala Ile Glu Lys Asn Lys Glu Gly
            340                 345                 350         
Leu His Asn Ala Lys Glu Ile Leu Thr Arg Leu Gly Val Glu Pro Ser
        355                 360                 365             
Asp Asp Asp Cys Val Ser Val Gln His Val Cys Thr Ile Val Ser Phe
    370                 375                 380                 
Arg Ser Ala Asn Leu Val Ala Ala Thr Leu Gly Ala Ile Leu Asn Arg
385                 390                 395                 400 
Leu Arg Asp Asn Lys Gly Thr Pro Arg Leu Arg Thr Thr Val Gly Val
                405                 410                 415     
Asp Gly Ser Leu Tyr Lys Thr His Pro Gln Tyr Ser Arg Arg Phe His
            420                 425                 430         
Lys Thr Leu Arg Arg Leu Val Pro Asp Ser Asp Val Arg Phe Leu Leu
        435                 440                 445             
Ser Glu Ser Gly Ser Gly Lys Gly Ala Ala Met Val Thr Ala Val Ala
    450                 455                 460                 
Tyr Arg Leu Ala Glu Gln His Arg Gln Ile Glu Glu Thr Leu Ala His
465                 470                 475                 480 
Phe His Leu Thr Lys Asp Met Leu Leu Glu Val Lys Lys Arg Met Arg
                485                 490                 495     
Ala Glu Met Glu Leu Gly Leu Arg Lys Gln Thr His Asn Asn Ala Val
            500                 505                 510         
Val Lys Met Leu Pro Ser Phe Val Arg Arg Thr Pro Asp Gly Thr Glu
        515                 520                 525             
Asn Gly Asp Phe Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val
    530                 535                 540                 
Leu Leu Val Lys Ile Arg Ser Gly Lys Lys Arg Thr Val Glu Met His
545                 550                 555                 560 
Asn Lys Ile Tyr Ala Ile Pro Ile Glu Ile Met Gln Gly Thr Gly Glu
                565                 570                 575     
Glu Leu Phe Asp His Ile Val Ser Cys Ile Ser Asp Phe Leu Asp Tyr
            580                 585                 590         
Met Gly Ile Lys Gly Pro Arg Met Pro Leu Gly Phe Thr Phe Ser Phe
        595                 600                 605             
Pro Cys Gln Gln Thr Ser Leu Asp Ala Gly Ile Leu Ile Thr Trp Thr
    610                 615                 620                 
Lys Gly Phe Lys Ala Thr Asp Cys Val Gly His Asp Val Val Thr Leu
625                 630                 635                 640 
Leu Arg Asp Ala Ile Lys Arg Arg Glu Glu Phe Asp Leu Asp Val Val
                645                 650                 655     
Ala Val Val Asn Asp Thr Val Gly Thr Met Met Thr Cys Ala Tyr Glu
            660                 665                 670         
Glu Pro Thr Cys Glu Val Gly Leu Ile Val Gly Thr Gly Ser Asn Ala
        675                 680                 685             
Cys Tyr Met Glu Glu Met Lys Asn Val Glu Met Val Glu Gly Asp Gln
    690                 695                 700                 
Gly Gln Met Cys Ile Asn Met Glu Trp Gly Ala Phe Gly Asp Asn Gly
705                 710                 715                 720 
Cys Leu Asp Asp Ile Arg Thr His Tyr Asp Arg Leu Val Asp Glu Tyr
                725                 730                 735     
Ser Leu Asn Ala Gly Lys Gln Arg Tyr Glu Lys Met Ile Ser Gly Met
            740                 745                 750         
Tyr Leu Gly Glu Ile Val Arg Asn Ile Leu Ile Asp Phe Thr Lys Lys
        755                 760                 765             
Gly Phe Leu Phe Arg Gly Gln Ile Ser Glu Thr Leu Lys Thr Arg Gly
    770                 775                 780                 
Ile Phe Glu Thr Lys Phe Leu Ser Gln Ile Glu Ser Asp Arg Leu Ala
785                 790                 795                 800 
Leu Leu Gln Val Arg Ala Ile Leu Gln Gln Leu Gly Leu Asn Ser Thr
                805                 810                 815     
Cys Asp Asp Ser Ile Leu Val Lys Thr Val Cys Gly Val Val Ser Arg
            820                 825                 830         
Arg Ala Ala Gln Leu Cys Gly Ala Gly Met Ala Ala Val Val Asp Lys
        835                 840                 845             
Ile Arg Glu Asn Arg Gly Leu Asp Arg Leu Asn Val Thr Val Gly Val
    850                 855                 860                 
Asp Gly Thr Leu Tyr Lys Leu His Pro His Phe Ser Arg Ile Met His
865                 870                 875                 880 
Gln Thr Val Lys Glu Leu Ser Pro Lys Cys Asn Val Ser Phe Leu Leu
                885                 890                 895     
Ser Glu Asp Gly Ser Gly Lys Gly Ala Ala Leu Ile Thr Ala Val Gly
            900                 905                 910         
Val Arg Leu Arg Thr Glu Ala Ser Ser
        915                 920     


<210> 2409
<211> 230
<212> PRT
<213> Homo sapiens

<400> 2409
Met Leu Ala Arg Ala Pro Ser Ser Ser Ser Ser Ser Arg Cys Trp Ala
 1               5                  10                  15      
Thr Arg Leu Arg Pro Cys Arg Ser Pro Arg Glu Gly Thr Pro Arg Ala
            20                  25                  30          
Ser Ala Val Trp Pro Ala Val Thr Pro Ala Ser Arg Gly Ala Ala Pro
        35                  40                  45              
Gly Thr Ser Pro Arg Arg Pro Ser Val Val Pro Cys Arg Thr Gly Pro
    50                  55                  60                  
His Ser Leu Trp Val Pro Ala Thr Ala Cys Ser Cys Pro Gln Ala Ala
65                  70                  75                  80  
Cys Trp Tyr Pro Pro Thr Pro Thr Ala Trp Thr Ala Glu Ser Val Leu
                85                  90                  95      
Ala Arg Ser Ala Gly Pro Ala Leu Thr Pro Ser Pro Ser Thr Ala Met
            100                 105                 110         
Thr Thr Ala Ala Pro Gly Ala Val Glu Ala Ser Cys Pro Thr Cys Ala
        115                 120                 125             
Gln Ala Ser Ala Ser Trp Arg Arg Trp Thr Val Gly Arg Pro Ala Ala
    130                 135                 140                 
Ser Ser Thr Ala Met Pro Gly Ala His Trp Ala Ala Val Cys Arg Arg
145                 150                 155                 160 
Ser Ala Leu Thr Arg Ala Pro Pro Ser Cys Pro Gln Ser Ala Trp Leu
                165                 170                 175     
Pro Cys Pro Arg Leu Pro Gly Ala Ala Arg Ala Ala Ser Trp Ala Ser
            180                 185                 190         
Gln Pro Pro Pro Pro Thr Gly His Gly Met Thr Val Gly Gln Trp Ala
        195                 200                 205             
Pro Gly Val Pro Ser Ser Leu His Ser Ser Val Leu Glu Ser Thr Asn
    210                 215                 220                 
Pro Gln Arg Arg Leu Leu
225                 230 


<210> 2410
<211> 639
<212> PRT
<213> Homo sapiens

<400> 2410
Met Leu Leu Trp Leu Leu Leu Leu Ile Leu Thr Pro Gly Arg Glu Gln
 1               5                  10                  15      
Ser Gly Val Ala Pro Lys Ala Val Leu Leu Leu Asn Pro Pro Trp Ser
            20                  25                  30          
Thr Ala Phe Lys Gly Glu Lys Val Ala Leu Ile Cys Ser Ser Ile Ser
        35                  40                  45              
His Ser Leu Ala Gln Gly Asp Thr Tyr Trp Tyr His Asp Glu Lys Leu
    50                  55                  60                  
Leu Lys Ile Lys His Asp Lys Ile Gln Ile Thr Glu Pro Gly Asn Tyr
65                  70                  75                  80  
Gln Cys Lys Thr Arg Gly Ser Ser Leu Ser Asp Ala Val His Val Glu
                85                  90                  95      
Phe Ser Pro Asp Trp Leu Ile Leu Gln Ala Leu His Pro Val Phe Glu
            100                 105                 110         
Gly Asp Asn Val Ile Leu Arg Cys Gln Gly Lys Asp Asn Lys Asn Thr
        115                 120                 125             
His Gln Lys Val Tyr Tyr Lys Asp Gly Lys Gln Leu Pro Asn Ser Tyr
    130                 135                 140                 
Asn Leu Glu Lys Ile Thr Val Asn Ser Val Ser Arg Asp Asn Ser Lys
145                 150                 155                 160 
Tyr His Cys Thr Ala Tyr Arg Lys Phe Tyr Ile Leu Asp Ile Glu Val
                165                 170                 175     
Thr Ser Lys Pro Leu Asn Ile Gln Val Gln Gly Val Pro Val Ser Asn
            180                 185                 190         
Val Asn Leu Glu Ile Arg Pro Thr Gly Gly Gln Leu Ile Glu Gly Glu
        195                 200                 205             
Asn Met Val Leu Ile Cys Ser Val Ala Gln Gly Ser Gly Thr Val Thr
    210                 215                 220                 
Phe Ser Trp His Lys Glu Gly Arg Val Arg Ser Leu Gly Arg Lys Thr
225                 230                 235                 240 
Gln Arg Ser Leu Leu Ala Glu Leu His Val Leu Thr Val Lys Glu Ser
                245                 250                 255     
Asp Ala Gly Arg Tyr Tyr Cys Ala Ala Asp Asn Val His Ser Pro Ile
            260                 265                 270         
Leu Ser Thr Trp Ile Arg Val Thr Val Arg Ile Pro Val Ser His Pro
        275                 280                 285             
Val Leu Thr Phe Arg Ala Pro Arg Ala His Thr Val Val Gly Asp Leu
    290                 295                 300                 
Leu Glu Leu His Cys Glu Ser Leu Arg Gly Ser Pro Pro Ile Leu Tyr
305                 310                 315                 320 
Arg Phe Tyr His Glu Asp Val Thr Leu Gly Asn Ser Ser Ala Pro Ser
                325                 330                 335     
Gly Gly Gly Ala Ser Phe Asn Leu Ser Leu Thr Ala Glu His Ser Gly
            340                 345                 350         
Asn Tyr Ser Cys Asp Ala Asp Asn Gly Leu Gly Ala Gln His Ser His
        355                 360                 365             
Gly Val Ser Leu Arg Val Thr Val Pro Val Ser Arg Pro Val Leu Thr
    370                 375                 380                 
Leu Arg Ala Pro Gly Ala Gln Ala Val Val Gly Asp Leu Leu Glu Leu
385                 390                 395                 400 
His Cys Glu Ser Leu Arg Gly Ser Phe Pro Ile Leu Tyr Trp Phe Tyr
                405                 410                 415     
His Glu Asp Asp Thr Leu Gly Asn Ile Ser Ala His Ser Gly Gly Gly
            420                 425                 430         
Ala Ser Phe Asn Leu Ser Leu Thr Thr Glu His Ser Gly Asn Tyr Ser
        435                 440                 445             
Cys Glu Ala Asp Asn Gly Leu Gly Ala Gln His Ser Lys Val Val Thr
    450                 455                 460                 
Leu Asn Val Thr Gly Thr Ser Arg Asn Arg Thr Gly Leu Thr Ala Ala
465                 470                 475                 480 
Gly Ile Thr Gly Leu Val Leu Ser Ile Leu Val Leu Ala Ala Ala Ala
                485                 490                 495     
Ala Leu Leu His Tyr Ala Arg Ala Arg Arg Lys Pro Gly Gly Leu Ser
            500                 505                 510         
Ala Thr Gly Thr Ser Ser His Ser Pro Ser Glu Cys Gln Glu Pro Ser
        515                 520                 525             
Ser Ser Arg Pro Ser Arg Ile Asp Pro Gln Glu Pro Thr His Ser Lys
    530                 535                 540                 
Pro Leu Ala Pro Met Glu Leu Glu Pro Met Tyr Ser Asn Val Asn Pro
545                 550                 555                 560 
Gly Asp Ser Asn Pro Ile Tyr Ser Gln Ile Trp Ser Ile Gln His Thr
                565                 570                 575     
Lys Glu Asn Ser Ala Asn Cys Pro Met Met His Gln Glu His Glu Glu
            580                 585                 590         
Leu Thr Val Leu Tyr Ser Glu Leu Lys Lys Thr His Pro Asp Asp Ser
        595                 600                 605             
Ala Gly Glu Ala Ser Ser Arg Gly Arg Ala His Glu Glu Asp Asp Glu
    610                 615                 620                 
Glu Asn Tyr Glu Asn Val Pro Arg Val Leu Leu Ala Ser Asp His
625                 630                 635                 


<210> 2411
<211> 369
<212> PRT
<213> Homo sapiens

<400> 2411
Met Tyr Ala Met Lys Tyr Met Asn Lys Gln Gln Cys Ile Glu Arg Asp
 1               5                  10                  15      
Glu Val Arg Asn Val Phe Arg Glu Leu Glu Ile Leu Gln Glu Ile Glu
            20                  25                  30          
His Val Phe Leu Val Asn Leu Trp Tyr Ser Phe Gln Asp Glu Glu Asp
        35                  40                  45              
Met Phe Met Val Val Asp Leu Leu Leu Gly Gly Asp Leu Arg Tyr His
    50                  55                  60                  
Leu Gln Gln Asn Val Gln Phe Ser Glu Asp Thr Val Arg Leu Tyr Ile
65                  70                  75                  80  
Cys Glu Met Ala Leu Ala Leu Asp Tyr Leu Arg Gly Gln His Ile Ile
                85                  90                  95      
His Arg Asp Val Lys Pro Asp Asn Ile Leu Leu Asp Glu Arg Gly His
            100                 105                 110         
Ala His Leu Thr Asp Phe Asn Ile Ala Thr Ile Ile Lys Asp Gly Glu
        115                 120                 125             
Arg Ala Thr Ala Leu Ala Gly Thr Lys Pro Tyr Met Ala Pro Glu Ile
    130                 135                 140                 
Phe His Ser Phe Val Asn Gly Gly Thr Gly Tyr Ser Phe Glu Val Asp
145                 150                 155                 160 
Trp Trp Ser Val Gly Val Met Ala Tyr Glu Leu Leu Arg Gly Trp Arg
                165                 170                 175     
Pro Tyr Asp Ile His Ser Ser Asn Ala Val Glu Ser Leu Val Gln Leu
            180                 185                 190         
Phe Ser Thr Val Ser Val Gln Tyr Val Pro Thr Trp Ser Lys Glu Met
        195                 200                 205             
Val Ala Leu Leu Arg Lys Leu Leu Thr Val Asn Pro Glu His Arg Leu
    210                 215                 220                 
Ser Ser Leu Gln Asp Val Gln Ala Ala Pro Ala Leu Ala Gly Val Leu
225                 230                 235                 240 
Trp Asp His Leu Ser Glu Lys Arg Val Glu Pro Gly Phe Val Pro Asn
                245                 250                 255     
Lys Gly Arg Leu His Cys Asp Pro Thr Phe Glu Leu Glu Glu Met Ile
            260                 265                 270         
Leu Glu Ser Arg Pro Leu His Lys Lys Lys Lys Arg Leu Ala Lys Asn
        275                 280                 285             
Lys Ser Arg Asp Asn Ser Arg Asp Ser Ser Gln Ser Glu Asn Asp Tyr
    290                 295                 300                 
Leu Gln Asp Cys Leu Asp Ala Ile Gln Gln Asp Phe Val Ile Phe Asn
305                 310                 315                 320 
Arg Glu Lys Leu Lys Arg Ser Gln Asp Leu Pro Arg Glu Pro Leu Pro
                325                 330                 335     
Ala Pro Glu Ser Arg Asp Ala Ala Glu Pro Val Glu Asp Glu Ala Glu
            340                 345                 350         
Arg Ser Ala Leu Pro Met Cys Gly Pro Ile Cys Pro Ser Ala Gly Ser
        355                 360                 365             
Gly
    


<210> 2412
<211> 1000
<212> PRT
<213> Homo sapiens

<400> 2412
Met Ala Glu Arg Lys Pro Asn Gly Gly Ser Gly Gly Ala Ser Thr Ser
 1               5                  10                  15      
Ser Ser Gly Thr Asn Leu Leu Phe Ser Ser Ser Ala Thr Glu Phe Ser
            20                  25                  30          
Phe Asn Val Pro Phe Ile Pro Val Thr Gln Ala Ser Ala Ser Pro Ala
        35                  40                  45              
Ser Leu Leu Leu Pro Gly Glu Asp Ser Thr Asp Val Gly Glu Glu Asp
    50                  55                  60                  
Ser Phe Leu Gly Gln Thr Ser Ile His Thr Ser Ala Pro Gln Thr Phe
65                  70                  75                  80  
Ser Tyr Phe Ser Gln Val Ser Ser Ser Ser Asp Pro Phe Gly Asn Ile
                85                  90                  95      
Gly Gln Ser Pro Leu Thr Thr Ala Ala Thr Ser Val Gly Gln Ser Gly
            100                 105                 110         
Phe Pro Lys Pro Leu Thr Ala Leu Pro Phe Thr Thr Gly Ser Gln Asp
        115                 120                 125             
Val Ser Asn Ala Phe Ser Pro Ser Ile Ser Lys Ala Gln Pro Gly Ala
    130                 135                 140                 
Pro Pro Ser Ser Leu Met Gly Ile Asn Ser Tyr Leu Pro Ser Gln Pro
145                 150                 155                 160 
Ser Ser Leu Pro Pro Ser Tyr Phe Gly Asn Gln Pro Gln Gly Ile Pro
                165                 170                 175     
Gln Pro Gly Tyr Asn Pro Tyr Arg His Thr Pro Gly Ser Ser Arg Ala
            180                 185                 190         
Asn Pro Tyr Ile Ala Pro Pro Gln Leu Gln Gln Cys Gln Thr Pro Gly
        195                 200                 205             
Pro Pro Ala His Pro Pro Pro Ser Gly Pro Pro Val Gln Met Tyr Gln
    210                 215                 220                 
Met Pro Pro Gly Ser Leu Pro Pro Val Pro Ser Ser Val Gln Ser Pro
225                 230                 235                 240 
Ala Gln Gln Gln Val Pro Ala Arg Pro Gly Ala Pro Ser Val Gln Val
                245                 250                 255     
Pro Ser Pro Phe Leu Leu Gln Asn Gln Tyr Glu Pro Val Gln Pro His
            260                 265                 270         
Trp Phe Tyr Cys Lys Glu Val Glu Tyr Lys Gln Leu Trp Met Pro Phe
        275                 280                 285             
Ser Val Phe Asp Ser Leu Asn Leu Glu Glu Ile Tyr Asn Ser Val Gln
    290                 295                 300                 
Pro Asp Pro Glu Ser Val Val Leu Gly Thr Asp Gly Gly Arg Tyr Asp
305                 310                 315                 320 
Val Tyr Leu Tyr Asp Arg Ile Arg Lys Ala Ala Tyr Trp Glu Glu Glu
                325                 330                 335     
Pro Ala Glu Val Arg Arg Cys Thr Trp Phe Tyr Lys Gly Asp Thr Asp
            340                 345                 350         
Ser Arg Phe Ile Pro Tyr Thr Glu Glu Phe Ser Glu Lys Leu Glu Ala
        355                 360                 365             
Glu Tyr Lys Lys Ala Val Thr Thr Asn Gln Trp His Arg Arg Leu Glu
    370                 375                 380                 
Phe Pro Ser Gly Glu Thr Ile Val Met His Asn Pro Lys Val Ile Val
385                 390                 395                 400 
Gln Phe Gln Pro Ser Ser Val Pro Asp Glu Trp Gly Thr Thr Gln Asp
                405                 410                 415     
Gly Gln Thr Arg Pro Arg Val Val Lys Arg Gly Ile Asp Asp Asn Leu
            420                 425                 430         
Asp Glu Ile Pro Asp Gly Glu Met Pro Gln Val Asp His Leu Val Phe
        435                 440                 445             
Val Val His Gly Ile Gly Pro Val Cys Asp Leu Arg Phe Arg Ser Ile
    450                 455                 460                 
Ile Glu Cys Val Asp Asp Phe Arg Val Val Ser Leu Lys Leu Leu Arg
465                 470                 475                 480 
Thr His Phe Lys Lys Ser Leu Asp Asp Gly Lys Val Ser Arg Val Glu
                485                 490                 495     
Phe Leu Pro Val His Trp His Ser Ser Leu Gly Gly Asp Ala Thr Gly
            500                 505                 510         
Val Asp Arg Asn Ile Lys Lys Ile Thr Leu Pro Ser Ile Gly Arg Phe
        515                 520                 525             
Arg His Phe Thr Asn Glu Thr Leu Leu Asp Ile Leu Phe Tyr Asn Ser
    530                 535                 540                 
Pro Thr Tyr Cys Gln Thr Ile Val Glu Lys Val Gly Met Glu Ile Asn
545                 550                 555                 560 
His Leu His Ala Leu Phe Met Ser Arg Asn Pro Asp Phe Lys Gly Gly
                565                 570                 575     
Val Ser Val Ala Gly His Ser Leu Gly Ser Leu Ile Leu Phe Asp Ile
            580                 585                 590         
Leu Ser Asn Gln Lys Asp Leu Asn Leu Ser Lys Cys Pro Gly Pro Leu
        595                 600                 605             
Ala Val Ala Asn Gly Val Val Lys Gln Leu His Phe Gln Glu Lys Gln
    610                 615                 620                 
Met Pro Glu Glu Pro Lys Leu Thr Leu Asp Glu Ser Tyr Asp Leu Val
625                 630                 635                 640 
Val Glu Asn Glu Glu Val Leu Thr Leu Gln Glu Thr Leu Glu Ala Leu
                645                 650                 655     
Ser Leu Ser Glu Tyr Phe Ser Thr Phe Glu Lys Glu Lys Ile Asp Met
            660                 665                 670         
Glu Ser Leu Leu Met Cys Thr Val Asp Asp Leu Lys Glu Met Gly Ile
        675                 680                 685             
Pro Leu Gly Pro Arg Lys Lys Ile Ala Asn Phe Val Glu His Lys Ala
    690                 695                 700                 
Ala Lys Leu Lys Lys Ala Ala Ser Glu Lys Lys Ala Val Ala Ala Thr
705                 710                 715                 720 
Ser Thr Lys Gly Gln Glu Gln Ser Ala Gln Lys Thr Lys Asp Met Ala
                725                 730                 735     
Ser Leu Pro Ser Glu Ser Asn Glu Pro Lys Arg Lys Leu Pro Val Gly
            740                 745                 750         
Ala Cys Val Ser Ser Val Cys Val Asn Tyr Glu Ser Phe Glu Val Gly
        755                 760                 765             
Ala Gly Gln Val Ser Val Ala Tyr Asn Ser Leu Asp Phe Glu Pro Glu
    770                 775                 780                 
Ile Phe Phe Ala Leu Gly Ser Pro Ile Ala Met Phe Leu Thr Ile Arg
785                 790                 795                 800 
Gly Val Asp Arg Ile Asp Glu Asn Tyr Ser Leu Pro Thr Cys Lys Gly
                805                 810                 815     
Phe Phe Asn Ile Tyr His Pro Leu Asp Pro Val Ala Tyr Arg Leu Glu
            820                 825                 830         
Pro Met Ile Val Pro Asp Leu Asp Leu Lys Ala Val Leu Ile Pro His
        835                 840                 845             
His Lys Gly Arg Lys Arg Leu His Leu Glu Leu Lys Glu Ser Leu Ser
    850                 855                 860                 
Arg Met Gly Ser Asp Leu Lys Gln Gly Phe Ile Ser Ser Leu Lys Ser
865                 870                 875                 880 
Ala Trp Gln Thr Leu Asn Glu Phe Ala Arg Ala His Thr Ser Ser Thr
                885                 890                 895     
Gln Leu Gln Glu Glu Leu Glu Lys Val Ala Asn Gln Ile Lys Glu Glu
            900                 905                 910         
Glu Glu Lys Gln Val Val Glu Ala Glu Lys Val Val Glu Ser Pro Asp
        915                 920                 925             
Phe Ser Lys Asp Glu Asp Tyr Leu Gly Lys Val Gly Met Leu Asn Gly
    930                 935                 940                 
Gly Arg Arg Ile Asp Tyr Val Leu Gln Glu Lys Pro Ile Glu Ser Phe
945                 950                 955                 960 
Asn Glu Tyr Leu Phe Ala Leu Gln Ser His Leu Cys Tyr Trp Glu Ser
                965                 970                 975     
Glu Asp Thr Ala Leu Leu Leu Leu Lys Glu Ile Tyr Arg Thr Met Asn
            980                 985                 990         
Ile Ser Pro Glu Gln Pro Gln His
        995                 1000


<210> 2413
<211> 115
<212> PRT
<213> Homo sapiens

<400> 2413
Met Thr Lys Lys Arg Arg Asn Asn Gly Arg Ala Lys Lys Gly Arg Gly
 1               5                  10                  15      
Leu Val Gln Pro Ile Arg Cys Thr Asn Cys Ala Arg Cys Val Pro Lys
            20                  25                  30          
Asp Lys Ala Ile Lys Lys Phe Val Ile Arg Asn Ile Val Glu Ala Ala
        35                  40                  45              
Ala Val Arg Asp Met Ser Glu Ala Ser Val Phe Asp Ala Tyr Val Leu
    50                  55                  60                  
Pro Lys Leu Tyr Val Lys Leu His Tyr Cys Leu Ser Cys Ala Val His
65                  70                  75                  80  
Ser Lys Val Val Arg Asn Arg Ser Arg Glu Ala Arg Lys Asp Arg Thr
                85                  90                  95      
Pro Pro Pro Arg Phe Arg Thr Ala Gly Ala Ala Pro Cys Pro Leu Pro
            100                 105                 110         
Lys Pro Met
        115 


<210> 2414
<211> 664
<212> PRT
<213> Homo sapiens

<400> 2414
Met Ser Gly Val Arg Gly Leu Ser Arg Leu Leu Ser Ala Arg Arg Leu
 1               5                  10                  15      
Ala Leu Ala Lys Ala Trp Pro Thr Val Leu Gln Thr Gly Thr Arg Gly
            20                  25                  30          
Phe His Phe Thr Val Asp Gly Asn Lys Arg Ala Ser Ala Lys Val Ser
        35                  40                  45              
Asp Ser Ile Ser Ala Gln Tyr Pro Val Val Asp His Glu Phe Asp Ala
    50                  55                  60                  
Val Val Val Gly Ala Gly Gly Ala Gly Leu Arg Ala Ala Phe Gly Leu
65                  70                  75                  80  
Ser Glu Ala Gly Phe Asn Thr Ala Cys Val Thr Lys Leu Phe Pro Thr
                85                  90                  95      
Arg Ser His Thr Val Ala Ala Gln Gly Gly Ile Asn Ala Ala Leu Gly
            100                 105                 110         
Asn Met Glu Glu Asp Asn Trp Arg Trp His Phe Tyr Asp Thr Val Lys
        115                 120                 125             
Gly Ser Asp Trp Leu Gly Asp Gln Asp Ala Ile His Tyr Met Thr Glu
    130                 135                 140                 
Gln Ala Pro Ala Ala Val Val Glu Leu Glu Asn Tyr Gly Met Pro Phe
145                 150                 155                 160 
Ser Arg Thr Glu Asp Gly Lys Ile Tyr Gln Arg Ala Phe Gly Gly Gln
                165                 170                 175     
Ser Leu Lys Phe Gly Lys Gly Gly Gln Ala His Arg Cys Cys Cys Val
            180                 185                 190         
Ala Asp Arg Thr Gly His Ser Leu Leu His Thr Leu Tyr Gly Arg Ser
        195                 200                 205             
Leu Arg Tyr Asp Thr Ser Tyr Phe Val Glu Tyr Phe Ala Leu Asp Leu
    210                 215                 220                 
Leu Met Glu Asn Gly Glu Cys Arg Gly Val Ile Ala Leu Cys Ile Glu
225                 230                 235                 240 
Asp Gly Ser Ile His Arg Ile Arg Ala Lys Asn Thr Val Val Ala Thr
                245                 250                 255     
Gly Gly Tyr Gly Arg Thr Tyr Phe Ser Cys Thr Ser Ala His Thr Ser
            260                 265                 270         
Thr Gly Asp Gly Thr Ala Met Ile Thr Arg Ala Gly Leu Pro Cys Gln
        275                 280                 285             
Asp Leu Glu Phe Val Gln Phe His Pro Thr Gly Ile Tyr Gly Ala Gly
    290                 295                 300                 
Cys Leu Ile Thr Glu Gly Cys Arg Gly Glu Gly Gly Ile Leu Ile Asn
305                 310                 315                 320 
Ser Gln Gly Glu Arg Phe Met Glu Arg Tyr Ala Pro Val Ala Lys Asp
                325                 330                 335     
Leu Ala Ser Arg Asp Val Val Ser Arg Ser Met Thr Leu Glu Ile Arg
            340                 345                 350         
Glu Gly Arg Gly Cys Gly Pro Glu Lys Asp His Val Tyr Leu Gln Leu
        355                 360                 365             
His His Leu Pro Pro Glu Gln Leu Ala Thr Arg Leu Pro Gly Ile Ser
    370                 375                 380                 
Glu Thr Ala Met Ile Phe Ala Gly Val Asp Val Thr Lys Glu Pro Ile
385                 390                 395                 400 
Pro Val Leu Pro Thr Val His Tyr Asn Met Gly Gly Ile Pro Thr Asn
                405                 410                 415     
Tyr Lys Gly Gln Val Leu Arg His Val Asn Gly Gln Asp Gln Ile Val
            420                 425                 430         
Pro Gly Leu Tyr Ala Cys Gly Glu Ala Ala Cys Ala Ser Val His Gly
        435                 440                 445             
Ala Asn Arg Leu Gly Ala Asn Ser Leu Leu Asp Leu Val Val Phe Gly
    450                 455                 460                 
Arg Ala Cys Ala Leu Ser Ile Glu Glu Ser Cys Arg Pro Gly Asp Lys
465                 470                 475                 480 
Val Pro Pro Ile Lys Pro Asn Ala Gly Glu Glu Ser Val Met Asn Leu
                485                 490                 495     
Asp Lys Leu Arg Phe Ala Asp Gly Ser Ile Arg Thr Ser Glu Leu Arg
            500                 505                 510         
Leu Ser Met Gln Lys Ser Met Gln Asn His Ala Ala Val Phe Arg Val
        515                 520                 525             
Gly Ser Val Leu Gln Glu Gly Cys Gly Lys Ile Ser Lys Leu Tyr Gly
    530                 535                 540                 
Asp Leu Lys His Leu Lys Thr Phe Asp Arg Gly Met Val Trp Asn Thr
545                 550                 555                 560 
Asp Leu Val Glu Thr Leu Glu Leu Gln Asn Leu Met Leu Cys Ala Leu
                565                 570                 575     
Gln Thr Ile Tyr Gly Ala Glu Ala Arg Lys Glu Ser Arg Gly Ala His
            580                 585                 590         
Ala Arg Glu Asp Tyr Lys Val Arg Ile Asp Glu Tyr Asp Tyr Ser Lys
        595                 600                 605             
Pro Ile Gln Gly Gln Gln Lys Lys Pro Phe Glu Glu His Trp Arg Lys
    610                 615                 620                 
His Thr Leu Ser Tyr Val Asp Val Gly Thr Gly Lys Val Thr Leu Glu
625                 630                 635                 640 
Tyr Arg Pro Val Ile Asp Lys Thr Leu Asn Glu Ala Asp Cys Ala Thr
                645                 650                 655     
Val Pro Pro Ala Ile Arg Ser Tyr
            660                 


<210> 2415
<211> 170
<212> PRT
<213> Homo sapiens

<400> 2415
Met Leu Leu Asn Val Ala Leu Val Ala Leu Val Leu Leu Gly Ala Tyr
 1               5                  10                  15      
Arg Leu Trp Val Arg Trp Gly Arg Arg Gly Leu Gly Ala Gly Ala Gly
            20                  25                  30          
Ala Gly Glu Glu Ser Pro Ala Thr Ser Leu Pro Arg Met Lys Lys Arg
        35                  40                  45              
Asp Phe Ser Leu Glu Gln Leu Arg Gln Tyr Asp Gly Ser Arg Asn Pro
    50                  55                  60                  
Arg Ile Leu Leu Ala Val Asn Gly Lys Val Phe Asp Val Thr Lys Gly
65                  70                  75                  80  
Ser Lys Phe Tyr Gly Pro Ala Gly Pro Tyr Gly Ile Phe Ala Gly Arg
                85                  90                  95      
Asp Ala Ser Arg Gly Leu Ala Thr Phe Cys Leu Asp Lys Asp Ala Leu
            100                 105                 110         
Arg Asp Glu Tyr Asp Asp Leu Ser Asp Leu Asn Ala Val Gln Met Glu
        115                 120                 125             
Ser Val Arg Glu Trp Glu Met Gln Phe Lys Glu Lys Tyr Asp Tyr Val
    130                 135                 140                 
Gly Arg Leu Leu Lys Pro Gly Glu Glu Pro Ser Glu Tyr Thr Asp Glu
145                 150                 155                 160 
Glu Asp Thr Lys Asp His Asn Lys Gln Asp
                165                 170 


<210> 2416
<211> 180
<212> PRT
<213> Homo sapiens

<400> 2416
Met Val Cys Leu Phe Asn Lys Leu Tyr Gln Lys Leu Asn Leu Lys Lys
 1               5                  10                  15      
Leu Trp Gln Asn Leu Thr Leu Cys Ser Lys Lys Asp Met Lys Asn Phe
            20                  25                  30          
Phe Asp Lys Leu Gln Gln His Ser Ile Pro Val Phe Ile Phe Ser Ala
        35                  40                  45              
Gly Ile Ser Asp Val Leu Glu Glu Val Ile Arg Gln Ala Gly Val Tyr
    50                  55                  60                  
His Pro Asn Val Lys Val Val Ser Asn Phe Met Asp Phe Asp Glu Thr
65                  70                  75                  80  
Gly Val Leu Lys Gly Phe Lys Gly Val Leu Ile His Ile Phe Asn Lys
                85                  90                  95      
His Asp Gly Ala Leu Arg Asn Thr Glu Tyr Phe Asn Gln Leu Lys Asp
            100                 105                 110         
Asn Ser Asn Ile Ile Leu Leu Gly Asp Ser Gln Gly Asp Leu Arg Met
        115                 120                 125             
Ala Asp Gly Val Ala Asn Val Glu His Ile Leu Lys Val Gly Tyr Leu
    130                 135                 140                 
Asn Asp Arg Val Asp Glu Leu Leu Glu Lys Tyr Met Asp Ser Tyr Asp
145                 150                 155                 160 
Ile Val Leu Val Gln Asp Glu Ser Leu Glu Val Ala Asn Ser Ile Leu
                165                 170                 175     
Gln Lys Ile Leu
            180 


<210> 2417
<211> 351
<212> PRT
<213> Homo sapiens

<400> 2417
Met Ala Ala Ala Pro Leu Lys Val Cys Ile Val Gly Ser Gly Asn Trp
 1               5                  10                  15      
Gly Ser Ala Val Ala Lys Ile Ile Gly Asn Asn Val Lys Lys Leu Gln
            20                  25                  30          
Lys Phe Ala Ser Thr Val Lys Met Trp Val Phe Glu Glu Thr Val Asn
        35                  40                  45              
Gly Arg Lys Leu Thr Asp Ile Ile Asn Asn Asp His Glu Asn Val Lys
    50                  55                  60                  
Tyr Leu Pro Gly His Lys Leu Pro Glu Asn Val Val Ala Met Ser Asn
65                  70                  75                  80  
Leu Ser Glu Ala Val Gln Asp Ala Asp Leu Leu Val Phe Val Ile Pro
                85                  90                  95      
His Gln Phe Ile His Arg Ile Cys Asp Glu Ile Thr Gly Arg Val Pro
            100                 105                 110         
Lys Lys Ala Leu Gly Ile Thr Leu Ile Lys Gly Ile Asp Glu Gly Pro
        115                 120                 125             
Glu Gly Leu Lys Leu Ile Ser Asp Ile Ile Arg Glu Lys Met Gly Ile
    130                 135                 140                 
Asp Ile Ser Val Leu Met Gly Ala Asn Ile Ala Asn Glu Val Ala Ala
145                 150                 155                 160 
Glu Lys Phe Cys Glu Thr Thr Ile Gly Ser Lys Val Met Glu Asn Gly
                165                 170                 175     
Leu Leu Phe Lys Glu Leu Leu Gln Thr Pro Asn Phe Arg Ile Thr Val
            180                 185                 190         
Val Asp Asp Ala Asp Thr Val Glu Leu Cys Gly Ala Leu Lys Asn Ile
        195                 200                 205             
Val Ala Val Gly Ala Gly Phe Cys Asp Gly Leu Arg Cys Gly Asp Asn
    210                 215                 220                 
Thr Lys Ala Ala Val Ile Arg Leu Gly Leu Met Glu Met Ile Ala Phe
225                 230                 235                 240 
Ala Arg Ile Phe Cys Lys Gly Gln Val Ser Thr Ala Thr Phe Leu Glu
                245                 250                 255     
Ser Cys Gly Val Ala Asp Leu Ile Thr Thr Cys Tyr Gly Gly Arg Asn
            260                 265                 270         
Arg Arg Gly Ala Glu Ala Phe Ala Arg Thr Gly Lys Thr Ile Glu Glu
        275                 280                 285             
Leu Glu Lys Glu Met Leu Asn Gly Gln Lys Leu Gln Gly Pro Gln Thr
    290                 295                 300                 
Ser Ala Glu Val Tyr Arg Ile Leu Lys Gln Lys Gly Leu Leu Asp Lys
305                 310                 315                 320 
Phe Pro Leu Phe Thr Ala Val Tyr Gln Ile Cys Tyr Glu Ser Arg Pro
                325                 330                 335     
Val Gln Glu Met Leu Ser Cys Leu Gln Ser His Pro Glu His Thr
            340                 345                 350     


<210> 2418
<211> 1313
<212> PRT
<213> Homo sapiens

<400> 2418
Met Leu Tyr Asn Lys Val Cys Asp Ile Val Ser Ser Leu Ser Glu Leu
 1               5                  10                  15      
Leu Glu Ile Gln Leu Leu Thr Asp Thr Thr Ile Leu Gln Val Ser Ser
            20                  25                  30          
Met Gly Ile Thr Pro Phe Phe Val Glu Asn Val Ser Glu Leu Gln Leu
        35                  40                  45              
Cys Ala Ile Lys Leu Val Thr Ala Val Phe Ser Arg Tyr Glu Lys His
    50                  55                  60                  
Arg Gln Leu Ile Leu Glu Glu Ile Phe Thr Ser Leu Ala Arg Leu Pro
65                  70                  75                  80  
Thr Ser Lys Arg Ser Leu Arg Asn Phe Arg Leu Asn Ser Ser Asp Met
                85                  90                  95      
Asp Gly Glu Pro Met Tyr Ile Gln Met Val Thr Ala Leu Val Leu Gln
            100                 105                 110         
Leu Ile Gln Cys Val Val His Leu Pro Ser Ser Glu Lys Asp Ser Asn
        115                 120                 125             
Ala Glu Glu Asp Ser Asn Lys Lys Ile Asp Gln Asp Val Val Ile Thr
    130                 135                 140                 
Asn Ser Tyr Glu Thr Ala Met Arg Thr Ala Gln Asn Phe Leu Ser Ile
145                 150                 155                 160 
Phe Leu Lys Lys Cys Gly Ser Lys Gln Gly Glu Glu Asp Tyr Arg Pro
                165                 170                 175     
Leu Phe Glu Asn Phe Val Gln Asp Leu Leu Ser Thr Val Asn Lys Pro
            180                 185                 190         
Glu Trp Pro Ala Ala Glu Leu Leu Leu Ser Leu Leu Gly Arg Leu Leu
        195                 200                 205             
Val His Gln Phe Ser Asn Lys Ser Thr Glu Met Ala Leu Arg Val Ala
    210                 215                 220                 
Ser Leu Asp Tyr Leu Gly Thr Val Ala Ala Arg Leu Arg Lys Asp Ala
225                 230                 235                 240 
Val Thr Ser Lys Met Asp Gln Gly Ser Ile Glu Arg Ile Leu Lys Gln
                245                 250                 255     
Val Ser Gly Gly Glu Asp Glu Ile Gln Gln Leu Gln Lys Ala Leu Leu
            260                 265                 270         
Asp Tyr Leu Asp Glu Asn Thr Glu Thr Asp Pro Ser Leu Val Phe Ser
        275                 280                 285             
Arg Lys Phe Tyr Ile Ala Gln Trp Phe Arg Asp Thr Thr Leu Glu Thr
    290                 295                 300                 
Glu Lys Ala Met Lys Ser Gln Lys Asp Glu Glu Ser Ser Glu Gly Thr
305                 310                 315                 320 
His His Ala Lys Glu Ile Glu Thr Thr Gly Gln Ile Met His Arg Ala
                325                 330                 335     
Glu Asn Arg Lys Lys Phe Leu Arg Ser Ile Ile Lys Thr Thr Pro Ser
            340                 345                 350         
Gln Phe Ser Thr Leu Lys Met Asn Ser Asp Thr Val Asp Tyr Asp Asp
        355                 360                 365             
Ala Cys Leu Ile Val Arg Tyr Leu Ala Ser Met Arg Pro Phe Ala Gln
    370                 375                 380                 
Ser Phe Asp Ile Tyr Leu Thr Gln Ile Leu Arg Val Leu Gly Glu Asn
385                 390                 395                 400 
Ala Ile Ala Val Arg Thr Lys Ala Met Lys Cys Leu Ser Glu Val Val
                405                 410                 415     
Ala Val Asp Pro Ser Ile Leu Ala Arg Leu Asp Met Gln Arg Gly Val
            420                 425                 430         
His Gly Arg Leu Met Asp Asn Ser Thr Ser Val Arg Glu Ala Ala Val
        435                 440                 445             
Glu Leu Leu Gly Arg Phe Val Leu Cys Arg Pro Gln Leu Ala Glu Gln
    450                 455                 460                 
Tyr Tyr Asp Met Leu Ile Glu Arg Ile Leu Asp Thr Gly Ile Ser Val
465                 470                 475                 480 
Arg Lys Arg Val Ile Lys Ile Leu Arg Asp Ile Cys Ile Glu Gln Pro
                485                 490                 495     
Thr Phe Pro Lys Ile Thr Glu Met Cys Val Lys Met Ile Arg Arg Val
            500                 505                 510         
Asn Asp Glu Glu Gly Ile Lys Lys Leu Val Asn Glu Thr Phe Gln Lys
        515                 520                 525             
Leu Trp Phe Thr Pro Thr Pro His Asn Asp Lys Glu Ala Met Thr Arg
    530                 535                 540                 
Lys Ile Leu Asn Ile Thr Asp Val Val Ala Ala Cys Arg Asp Thr Gly
545                 550                 555                 560 
Tyr Asp Trp Phe Glu Gln Leu Leu Gln Asn Leu Leu Lys Ser Glu Glu
                565                 570                 575     
Asp Ser Ser Tyr Lys Pro Val Lys Lys Ala Cys Thr Gln Leu Val Asp
            580                 585                 590         
Asn Leu Val Glu His Ile Leu Lys Tyr Glu Glu Ser Leu Ala Asp Ser
        595                 600                 605             
Asp Asn Lys Gly Val Asn Ser Gly Arg Leu Val Ala Cys Ile Thr Thr
    610                 615                 620                 
Leu Phe Leu Phe Ser Lys Ile Arg Pro Gln Leu Met Val Lys His Ala
625                 630                 635                 640 
Met Thr Met Gln Pro Tyr Leu Thr Thr Lys Cys Ser Thr Gln Asn Asp
                645                 650                 655     
Phe Met Val Ile Cys Asn Val Ala Lys Ile Leu Glu Leu Val Val Pro
            660                 665                 670         
Leu Met Glu His Pro Ser Glu Thr Phe Leu Ala Thr Ile Glu Glu Asp
        675                 680                 685             
Leu Met Lys Leu Ile Ile Lys Tyr Gly Met Thr Val Val Gln His Cys
    690                 695                 700                 
Val Ser Cys Leu Gly Ala Val Val Asn Lys Val Thr Gln Asn Phe Lys
705                 710                 715                 720 
Phe Val Trp Ala Cys Phe Asn Arg Tyr Tyr Gly Ala Ile Ser Lys Leu
                725                 730                 735     
Lys Ser Gln His Gln Glu Asp Pro Asn Asn Thr Ser Leu Leu Thr Asn
            740                 745                 750         
Lys Pro Ala Leu Leu Arg Ser Leu Phe Thr Val Gly Ala Leu Cys Arg
        755                 760                 765             
His Phe Asp Phe Asp Leu Glu Asp Phe Lys Gly Asn Ser Lys Val Asn
    770                 775                 780                 
Ile Lys Asp Lys Val Leu Glu Leu Leu Met Tyr Phe Thr Lys His Ser
785                 790                 795                 800 
Asp Glu Glu Val Gln Thr Lys Ala Ile Ile Gly Leu Gly Phe Ala Phe
                805                 810                 815     
Ile Gln His Pro Ser Leu Met Phe Glu Gln Glu Val Lys Asn Leu Tyr
            820                 825                 830         
Asn Asn Ile Leu Ser Asp Lys Asn Ser Ser Val Asn Leu Lys Ile Gln
        835                 840                 845             
Val Leu Lys Asn Leu Gln Thr Tyr Leu Gln Glu Glu Asp Thr Arg Met
    850                 855                 860                 
Gln Gln Ala Asp Arg Asp Trp Lys Lys Val Ala Lys Gln Glu Asp Leu
865                 870                 875                 880 
Lys Glu Met Gly Asp Val Ser Ser Gly Met Ser Ser Ser Ile Met Gln
                885                 890                 895     
Leu Tyr Leu Lys Gln Val Leu Glu Ala Phe Phe His Thr Gln Ser Ser
            900                 905                 910         
Val Arg His Phe Ala Leu Asn Val Ile Ala Leu Thr Leu Asn Gln Gly
        915                 920                 925             
Leu Ile His Pro Val Gln Cys Val Pro Tyr Leu Ile Ala Met Gly Thr
    930                 935                 940                 
Asp Pro Glu Pro Ala Met Arg Asn Lys Ala Asp Gln Gln Leu Val Glu
945                 950                 955                 960 
Ile Asp Lys Lys Tyr Ala Gly Phe Ile His Met Lys Ala Val Ala Gly
                965                 970                 975     
Met Lys Met Ser Tyr Gln Val Gln Gln Ala Ile Asn Thr Cys Leu Lys
            980                 985                 990         
Asp Pro Val Arg Gly Phe Arg Gln Asp Glu Ser Ser Ser Ala Leu Cys
        995                 1000                1005            
Ser His Leu Tyr Ser Met Ile Arg Gly Asn Arg Gln His Arg Arg Ala
    1010                1015                1020                
Phe Leu Ile Ser Leu Leu Asn Leu Phe Asp Asp Thr Ala Lys Thr Asp
1025                1030                1035                1040
Val Thr Met Leu Leu Tyr Ile Ala Asp Asn Leu Ala Cys Phe Pro Tyr
                1045                1050                1055    
Gln Thr Gln Glu Glu Pro Leu Phe Ile Met His His Ile Asp Ile Thr
            1060                1065                1070        
Leu Ser Val Ser Gly Ser Asn Leu Leu Gln Ser Phe Lys Glu Ser Met
        1075                1080                1085            
Val Lys Asp Lys Arg Lys Glu Arg Lys Ser Ser Pro Ser Lys Glu Asn
    1090                1095                1100                
Glu Ser Ser Asp Ser Glu Glu Glu Val Ser Arg Pro Arg Lys Ser Arg
1105                1110                1115                1120
Lys Arg Val Asp Ser Asp Ser Asp Ser Asp Ser Glu Asp Asp Ile Asn
                1125                1130                1135    
Ser Val Met Lys Cys Leu Pro Glu Asn Ser Ala Pro Leu Ile Glu Phe
            1140                1145                1150        
Ala Asn Val Ser Gln Gly Ile Leu Leu Leu Leu Met Leu Lys Gln His
        1155                1160                1165            
Leu Lys Asn Leu Cys Gly Phe Ser Asp Ser Lys Ile Gln Lys Tyr Ser
    1170                1175                1180                
Pro Ser Glu Ser Ala Lys Val Tyr Asp Lys Ala Ile Asn Arg Lys Thr
1185                1190                1195                1200
Gly Val His Phe His Pro Lys Gln Thr Leu Asp Phe Leu Arg Ser Asp
                1205                1210                1215    
Met Ala Asn Ser Lys Ile Thr Glu Glu Val Lys Arg Ser Ile Val Lys
            1220                1225                1230        
Gln Tyr Leu Asp Phe Lys Leu Leu Met Glu His Leu Asp Pro Asp Glu
        1235                1240                1245            
Glu Glu Glu Glu Gly Glu Val Ser Ala Ser Thr Asn Ala Arg Asn Lys
    1250                1255                1260                
Ala Ile Thr Ser Leu Leu Gly Gly Gly Ser Pro Lys Asn Asn Thr Ala
1265                1270                1275                1280
Ala Glu Thr Glu Asp Asp Glu Ser Asp Gly Glu Asp Arg Gly Gly Gly
                1285                1290                1295    
Thr Ser Gly Val Arg Arg Arg Arg Ser Gln Arg Ile Ser Gln Arg Ile
            1300                1305                1310        
Thr
    


<210> 2419
<211> 189
<212> PRT
<213> Homo sapiens

<400> 2419
Met Ala Ser Lys Arg Ala Leu Val Ile Leu Ala Lys Gly Ala Glu Glu
 1               5                  10                  15      
Met Glu Thr Val Ile Pro Val Asp Val Met Arg Arg Ala Gly Ile Lys
            20                  25                  30          
Val Thr Val Ala Gly Leu Ala Gly Lys Asp Pro Val Gln Cys Ser Arg
        35                  40                  45              
Asp Val Val Ile Cys Pro Asp Ala Ser Leu Glu Asp Ala Lys Lys Glu
    50                  55                  60                  
Gly Pro Tyr Asp Val Val Val Leu Pro Gly Gly Asn Leu Gly Ala Gln
65                  70                  75                  80  
Asn Leu Ser Glu Ser Ala Ala Val Lys Glu Ile Leu Lys Glu Gln Glu
                85                  90                  95      
Asn Arg Lys Gly Leu Ile Ala Ala Ile Cys Ala Gly Pro Thr Ala Leu
            100                 105                 110         
Leu Ala His Glu Ile Gly Phe Gly Ser Lys Val Thr Thr His Pro Leu
        115                 120                 125             
Ala Lys Asp Lys Met Met Asn Gly Gly His Tyr Thr Tyr Ser Glu Asn
    130                 135                 140                 
Arg Val Glu Lys Asp Gly Leu Ile Leu Thr Ser Arg Gly Pro Gly Thr
145                 150                 155                 160 
Ser Phe Glu Phe Ala Leu Ala Ile Val Glu Ala Leu Asn Gly Lys Glu
                165                 170                 175     
Val Ala Ala Gln Val Lys Ala Pro Leu Val Leu Lys Asp
            180                 185                 


<210> 2420
<211> 193
<212> PRT
<213> Homo sapiens

<400> 2420
Met Val Ala Thr Gly Ser Leu Ser Ser Lys Asn Pro Ala Ser Ile Ser
 1               5                  10                  15      
Glu Leu Leu Asp Cys Gly Tyr His Pro Glu Ser Leu Leu Ser Asp Phe
            20                  25                  30          
Asp Tyr Trp Asp Tyr Val Val Pro Glu Pro Asn Leu Asn Glu Val Ile
        35                  40                  45              
Phe Glu Glu Ser Thr Cys Gln Asn Leu Val Lys Met Leu Glu Asn Cys
    50                  55                  60                  
Leu Ser Lys Ser Lys Gln Thr Lys Leu Gly Cys Ser Lys Val Leu Val
65                  70                  75                  80  
Pro Glu Lys Leu Thr Gln Arg Ile Ala Gln Asp Val Leu Arg Leu Ser
                85                  90                  95      
Ser Thr Glu Pro Cys Gly Leu Arg Gly Cys Val Met His Val Asn Leu
            100                 105                 110         
Glu Ile Glu Asn Val Cys Lys Lys Leu Asp Arg Ile Val Cys Asp Ser
        115                 120                 125             
Ser Val Val Pro Thr Phe Glu Leu Thr Leu Val Phe Lys Gln Glu Asn
    130                 135                 140                 
Cys Ser Trp Thr Ser Phe Arg Asp Phe Phe Phe Ser Arg Gly Arg Phe
145                 150                 155                 160 
Ser Ser Gly Phe Arg Arg Thr Leu Ile Leu Ser Ser Gly Phe Arg Leu
                165                 170                 175     
Val Lys Lys Lys Leu Tyr Ser Leu Ile Gly Thr Thr Val Ile Glu Gly
            180                 185                 190         
Ser
    


<210> 2421
<211> 679
<212> PRT
<213> Homo sapiens

<400> 2421
Met Ile Ser Ala Ser Arg Ala Ala Ala Ala Arg Leu Val Gly Ala Ala
 1               5                  10                  15      
Ala Ser Arg Gly Pro Thr Ala Ala Arg His Gln Asp Ser Trp Asn Gly
            20                  25                  30          
Leu Ser His Glu Ala Phe Arg Leu Val Ser Arg Arg Asp Tyr Ala Ser
        35                  40                  45              
Glu Ala Ile Lys Gly Ala Val Val Gly Ile Asp Leu Gly Thr Thr Asn
    50                  55                  60                  
Ser Cys Val Ala Val Met Glu Gly Lys Gln Ala Lys Val Leu Glu Asn
65                  70                  75                  80  
Ala Glu Gly Ala Arg Thr Thr Pro Ser Val Val Ala Phe Thr Ala Asp
                85                  90                  95      
Gly Glu Arg Leu Val Gly Met Pro Ala Lys Arg Gln Ala Val Thr Asn
            100                 105                 110         
Pro Asn Asn Thr Phe Tyr Ala Thr Lys Arg Leu Ile Gly Arg Arg Tyr
        115                 120                 125             
Asp Asp Pro Glu Val Gln Lys Asp Ile Lys Asn Val Pro Phe Lys Ile
    130                 135                 140                 
Val Arg Ala Ser Asn Gly Asp Ala Trp Val Glu Ala His Gly Lys Leu
145                 150                 155                 160 
Tyr Ser Pro Ser Gln Ile Gly Ala Phe Val Leu Met Lys Met Lys Glu
                165                 170                 175     
Thr Ala Glu Asn Tyr Leu Gly His Thr Ala Lys Asn Ala Val Ile Thr
            180                 185                 190         
Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp Ala
        195                 200                 205             
Gly Gln Ile Ser Gly Leu Asn Val Leu Arg Val Ile Asn Glu Pro Thr
    210                 215                 220                 
Ala Ala Ala Leu Ala Tyr Gly Leu Asp Lys Ser Glu Asp Lys Val Ile
225                 230                 235                 240 
Ala Val Tyr Asp Leu Gly Gly Gly Thr Phe Asp Ile Ser Ile Leu Glu
                245                 250                 255     
Ile Gln Lys Gly Val Phe Glu Val Lys Ser Thr Asn Gly Asp Thr Phe
            260                 265                 270         
Leu Gly Gly Glu Asp Phe Asp Gln Ala Leu Leu Arg His Ile Val Lys
        275                 280                 285             
Glu Phe Lys Arg Glu Thr Gly Val Asp Leu Thr Lys Asp Asn Met Ala
    290                 295                 300                 
Leu Gln Arg Val Arg Glu Ala Ala Glu Lys Ala Lys Cys Glu Leu Ser
305                 310                 315                 320 
Ser Ser Val Gln Thr Asp Ile Asn Leu Pro Tyr Leu Thr Met Asp Ser
                325                 330                 335     
Ser Gly Pro Lys His Leu Asn Met Lys Leu Thr Arg Ala Gln Phe Glu
            340                 345                 350         
Gly Ile Val Thr Asp Leu Ile Arg Arg Thr Ile Ala Pro Cys Gln Lys
        355                 360                 365             
Ala Met Gln Asp Ala Glu Val Ser Lys Ser Asp Ile Gly Glu Val Ile
    370                 375                 380                 
Leu Val Gly Gly Met Thr Arg Met Pro Lys Val Gln Gln Thr Val Gln
385                 390                 395                 400 
Asp Leu Phe Gly Arg Ala Pro Ser Lys Ala Val Asn Pro Asp Glu Ala
                405                 410                 415     
Val Ala Ile Gly Ala Ala Ile Gln Gly Gly Val Leu Ala Gly Asp Val
            420                 425                 430         
Thr Asp Val Leu Leu Leu Asp Val Thr Pro Leu Ser Leu Gly Ile Glu
        435                 440                 445             
Thr Leu Gly Gly Val Phe Thr Lys Leu Ile Asn Arg Asn Thr Thr Ile
    450                 455                 460                 
Pro Thr Lys Lys Ser Gln Val Phe Ser Thr Ala Ala Asp Gly Gln Thr
465                 470                 475                 480 
Gln Val Glu Ile Lys Val Cys Gln Gly Glu Arg Glu Met Ala Gly Asp
                485                 490                 495     
Asn Lys Leu Leu Gly Gln Phe Thr Leu Ile Gly Ile Pro Pro Ala Pro
            500                 505                 510         
Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile Asp Ala Asn Gly
        515                 520                 525             
Ile Val His Val Ser Ala Lys Asp Lys Gly Thr Gly Arg Glu Gln Gln
    530                 535                 540                 
Ile Val Ile Gln Ser Ser Gly Gly Leu Ser Lys Asp Asp Ile Glu Asn
545                 550                 555                 560 
Met Val Lys Asn Ala Glu Lys Tyr Ala Glu Glu Asp Arg Arg Lys Lys
                565                 570                 575     
Glu Arg Val Glu Ala Val Asn Met Ala Glu Gly Ile Ile His Asp Thr
            580                 585                 590         
Glu Thr Lys Met Glu Glu Phe Lys Asp Gln Leu Pro Ala Asp Glu Cys
        595                 600                 605             
Asn Lys Leu Lys Glu Glu Ile Ser Lys Met Arg Glu Leu Leu Ala Arg
    610                 615                 620                 
Lys Asp Ser Glu Thr Gly Glu Asn Ile Arg Gln Ala Ala Ser Ser Leu
625                 630                 635                 640 
Gln Gln Ala Ser Leu Lys Leu Phe Glu Met Ala Tyr Lys Lys Met Ala
                645                 650                 655     
Ser Glu Arg Glu Gly Ser Gly Ser Ser Gly Thr Gly Glu Gln Lys Glu
            660                 665                 670         
Asp Gln Lys Glu Glu Lys Gln
        675                 


<210> 2422
<211> 306
<212> PRT
<213> Homo sapiens

<400> 2422
Met Leu Leu Thr Gln Val Lys Gln Leu Leu Ile Ile Lys Leu His Cys
 1               5                  10                  15      
Ser Ile Gln Cys Leu Leu Thr Pro Leu His Ala Leu Glu Thr Ile Ile
            20                  25                  30          
His Ile Thr Ile Gln Ile Ala Ser Val Pro Ser Thr Ser Leu Pro Ser
        35                  40                  45              
Arg Lys Pro Cys Leu Met Met Met Leu Thr Ser Phe Leu Thr Asp Leu
    50                  55                  60                  
Ser Leu Asp His Ser Asp Leu Val Ala Glu Leu Leu Lys Glu Leu Ser
65                  70                  75                  80  
Asn His Asn Glu Arg Val Glu Glu Arg Lys Ile Ala Leu Tyr Glu Leu
                85                  90                  95      
Met Lys Leu Thr Gln Glu Glu Ser Phe Ser Val Trp Asp Glu His Phe
            100                 105                 110         
Lys Thr Ile Leu Leu Leu Leu Leu Glu Thr Leu Gly Asp Lys Glu Pro
        115                 120                 125             
Thr Ile Arg Ala Leu Ala Leu Lys Val Leu Arg Glu Ile Leu Arg His
    130                 135                 140                 
Gln Pro Ala Arg Phe Lys Asn Tyr Ala Glu Leu Thr Val Met Lys Thr
145                 150                 155                 160 
Leu Glu Ala His Lys Asp Pro His Lys Glu Val Val Arg Ser Ala Glu
                165                 170                 175     
Glu Ala Ala Ser Val Leu Ala Thr Ser Ile Ser Pro Glu Gln Cys Ile
            180                 185                 190         
Lys Val Leu Cys Pro Ile Ile Gln Thr Ala Asp Tyr Pro Ile Asn Leu
        195                 200                 205             
Ala Ala Ile Lys Met Gln Thr Lys Val Ile Glu Arg Val Ser Lys Glu
    210                 215                 220                 
Thr Leu Asn Leu Leu Leu Pro Glu Ile Met Pro Gly Leu Ile Gln Gly
225                 230                 235                 240 
Tyr Asp Asn Ser Glu Ser Ser Val Arg Lys Ala Cys Val Phe Cys Leu
                245                 250                 255     
Val Ala Val His Ala Val Ile Gly Asp Glu Leu Lys Pro His Leu Ser
            260                 265                 270         
Gln Leu Thr Gly Ser Lys Met Lys Leu Leu Asn Leu Tyr Ile Lys Arg
        275                 280                 285             
Ala Gln Thr Gly Ser Gly Gly Ala Asp Pro Thr Thr Asp Val Ser Gly
    290                 295                 300                 
Gln Ser
305     


<210> 2423
<211> 435
<212> PRT
<213> Homo sapiens

<400> 2423
Met Leu Asn Met Gln Gly Ala Glu Glu Arg Asp Ile Arg Arg Glu Thr
 1               5                  10                  15      
Cys Pro Gly Trp Val Asn Lys Asn Lys Pro Ala Leu Glu Gln Asp Val
            20                  25                  30          
Cys Lys Ile Asp Ser Ser Gly Ile Val Val Lys Arg Phe Gln Glu Asp
        35                  40                  45              
Glu Tyr Gln Asp Ser Thr Phe Glu Glu Lys Tyr Ala Cys Glu Gly Met
    50                  55                  60                  
Lys Glu Asn Ser Pro Arg Glu Ile Ala Glu Ser Cys Leu Phe Gln Glu
65                  70                  75                  80  
Gly Gly Phe Gly Arg Ile Thr Phe Ile His Lys Glu Ala Pro Pro Glu
                85                  90                  95      
Ile Ile Ser Gln Gly Tyr Asn Phe Glu Lys Ser Leu Leu Leu Thr Ser
            100                 105                 110         
Ser Leu Val Thr Arg Leu Arg Val Ser Thr Glu Glu Ser Leu His Gln
        115                 120                 125             
Trp Glu Thr Ser Asn Ile Gln Thr Asn Asp Ile Ser Asp Gln Ser Lys
    130                 135                 140                 
Cys Pro Thr Leu Cys Thr Gln Lys Lys Ser Trp Lys Cys Asn Glu Cys
145                 150                 155                 160 
Gly Lys Thr Phe Thr Gln Ser Ser Ser Leu Thr Gln His Gln Arg Thr
                165                 170                 175     
His Thr Gly Glu Arg Pro Tyr Thr Cys Glu Glu Cys Gly Lys Ala Phe
            180                 185                 190         
Ser Arg Ser Ser Phe Leu Val Gln His Gln Arg Ile His Thr Gly Val
        195                 200                 205             
Lys Pro Tyr Gly Cys Glu Gln Cys Gly Lys Thr Phe Arg Cys Arg Ser
    210                 215                 220                 
Phe Leu Thr Gln His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Lys
225                 230                 235                 240 
Cys Asn Glu Cys Gly Asn Ser Phe Arg Asn His Ser His Leu Thr Glu
                245                 250                 255     
His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Arg Cys
            260                 265                 270         
Gly Lys Ala Phe Asn Gln Asn Thr His Leu Ile His His Gln Arg Ile
        275                 280                 285             
His Thr Gly Glu Lys Pro Tyr Ile Cys Ser Glu Cys Gly Ser Ser Phe
    290                 295                 300                 
Arg Lys His Ser Asn Leu Thr Gln His Gln Arg Ile His Thr Gly Glu
305                 310                 315                 320 
Lys Pro His Lys Cys Asp Glu Cys Gly Lys Thr Phe Gln Thr Lys Ala
                325                 330                 335     
Asn Leu Ser Gln His Gln Arg Leu His Ser Gly Glu Lys Pro Tyr Lys
            340                 345                 350         
Cys Lys Glu Cys Gly Lys Ala Phe Cys Gln Ser Pro Ser Leu Ile Lys
        355                 360                 365             
His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Lys Glu Cys
    370                 375                 380                 
Gly Lys Ala Phe Thr Gln Ser Thr Pro Leu Thr Lys His Gln Arg Ile
385                 390                 395                 400 
His Thr Gly Glu Arg Pro Tyr Lys Cys Ser Glu Cys Gly Leu Ala Phe
                405                 410                 415     
Ile Gln Ser Ile Cys Leu Ile Arg His Gln Arg Ser His Thr Trp Arg
            420                 425                 430         
Lys Thr Leu
        435 


<210> 2424
<211> 328
<212> PRT
<213> Homo sapiens

<400> 2424
Met Ala Ala Val Val Val Ala Ala Ala Gly Gly Ala Gly Pro Ala Val
 1               5                  10                  15      
Leu Gln Val Ala Gly Leu Tyr Arg Gly Leu Cys Ala Val Arg Ser Arg
            20                  25                  30          
Ala Leu Gly Leu Gly Leu Val Ser Pro Ala Gln Leu Arg Val Phe Pro
        35                  40                  45              
Val Arg Pro Gly Ser Gly Arg Pro Glu Gly Gly Ala Asp Ser Ser Gly
    50                  55                  60                  
Val Gly Ala Glu Ala Glu Leu Gln Ala Asn Pro Phe Tyr Asp Arg Tyr
65                  70                  75                  80  
Arg Asp Lys Ile Gln Leu Leu Arg Arg Ser Asp Pro Ala Ala Phe Glu
                85                  90                  95      
Ser Arg Leu Glu Lys Arg Ser Glu Phe Arg Lys Gln Pro Val Gly His
            100                 105                 110         
Ser Arg Gln Gly Asp Phe Ile Lys Cys Val Glu Gln Lys Thr Asp Ala
        115                 120                 125             
Leu Gly Lys Gln Ser Val Asn Arg Gly Phe Thr Lys Asp Lys Thr Leu
    130                 135                 140                 
Ser Ser Ile Phe Asn Ile Glu Met Val Lys Glu Lys Thr Ala Glu Glu
145                 150                 155                 160 
Ile Lys Gln Ile Trp Gln Gln Tyr Phe Ala Ala Lys Asp Thr Val Tyr
                165                 170                 175     
Ala Val Ile Pro Ala Glu Lys Phe Asp Leu Ile Trp Asn Arg Ala Gln
            180                 185                 190         
Ser Cys Pro Thr Phe Leu Cys Ala Leu Pro Arg Arg Glu Gly Tyr Glu
        195                 200                 205             
Phe Phe Val Gly Gln Trp Thr Gly Thr Glu Leu His Phe Thr Ala Leu
    210                 215                 220                 
Ile Asn Ile Gln Thr Arg Gly Glu Ala Ala Ala Ser Gln Leu Ile Leu
225                 230                 235                 240 
Tyr His Tyr Pro Glu Leu Lys Glu Glu Lys Gly Ile Val Leu Met Thr
                245                 250                 255     
Ala Glu Met Asp Ser Thr Phe Leu Asn Val Ala Glu Ala Gln Cys Ile
            260                 265                 270         
Ala Asn Gln Val Gln Leu Phe Tyr Ala Thr Asp Arg Lys Glu Thr Tyr
        275                 280                 285             
Gly Leu Val Glu Thr Phe Asn Leu Arg Pro Asn Glu Phe Lys Tyr Met
    290                 295                 300                 
Ser Val Ile Ala Glu Leu Glu Gln Ser Gly Leu Gly Ala Glu Leu Lys
305                 310                 315                 320 
Cys Ala Gln Asn Gln Asn Lys Thr
                325             


<210> 2425
<211> 700
<212> PRT
<213> Homo sapiens

<400> 2425
Met Lys Asn Met Leu Leu Asp Leu Gln Asn Gln Lys Tyr Ile Met Gln
 1               5                  10                  15      
Glu Asn Glu Asn Pro Asn Gly Asp Asp Ile Ser Arg Lys Lys Leu Leu
            20                  25                  30          
Val Asp Gln Met Phe Lys Tyr Phe Asp Ala Asp Ser Asn Gly Leu Val
        35                  40                  45              
Asp Ile Asn Glu Leu Thr Gln Val Ile Lys Gln Glu Glu Leu Gly Lys
    50                  55                  60                  
Asp Leu Phe Asp Cys Thr Leu Tyr Val Leu Leu Lys Tyr Asp Asp Phe
65                  70                  75                  80  
Asn Ala Asp Lys His Leu Ala Leu Glu Glu Phe Tyr Arg Ala Phe Gln
                85                  90                  95      
Val Ile Gln Leu Ser Leu Pro Glu Asp Gln Lys Leu Ser Ile Thr Ala
            100                 105                 110         
Ala Thr Val Gly Gln Ser Ala Val Leu Ser Cys Ala Ile Gln Gly Thr
        115                 120                 125             
Leu Arg Pro Pro Ile Ile Trp Lys Arg Asn Asn Ile Ile Leu Asn Asn
    130                 135                 140                 
Leu Asp Leu Glu Asp Ile Asn Asp Phe Gly Asp Asp Gly Ser Leu Tyr
145                 150                 155                 160 
Ile Thr Lys Val Thr Thr Thr His Val Gly Asn Tyr Thr Cys Tyr Ala
                165                 170                 175     
Asp Gly Tyr Glu Gln Val Tyr Gln Thr His Ile Phe Gln Val Asn Val
            180                 185                 190         
Pro Pro Val Ile Arg Val Tyr Pro Glu Ser Gln Ala Arg Glu Pro Gly
        195                 200                 205             
Val Thr Ala Ser Leu Arg Cys His Ala Glu Gly Ile Pro Lys Pro Gln
    210                 215                 220                 
Leu Gly Trp Leu Lys Asn Gly Ile Asp Ile Thr Pro Lys Leu Ser Lys
225                 230                 235                 240 
Gln Leu Thr Leu Gln Ala Asn Gly Ser Glu Val His Ile Ser Asn Val
                245                 250                 255     
Arg Tyr Glu Asp Thr Gly Ala Tyr Thr Cys Ile Ala Lys Asn Glu Ala
            260                 265                 270         
Gly Val Asp Glu Asp Ile Ser Ser Leu Phe Val Glu Asp Ser Ala Arg
        275                 280                 285             
Lys Thr Leu Ala Asn Ile Leu Trp Arg Glu Glu Gly Leu Gly Ile Gly
    290                 295                 300                 
Asn Met Phe Tyr Val Phe Tyr Glu Asp Gly Ile Lys Val Ile Gln Pro
305                 310                 315                 320 
Ile Glu Cys Glu Phe Gln Arg His Ile Lys Pro Ser Glu Lys Leu Leu
                325                 330                 335     
Gly Phe Gln Asp Glu Val Cys Pro Lys Ala Glu Gly Asp Glu Val Gln
            340                 345                 350         
Arg Cys Val Trp Ala Ser Ala Val Asn Val Lys Asp Lys Phe Ile Tyr
        355                 360                 365             
Val Ala Gln Pro Thr Leu Asp Arg Val Leu Ile Val Asp Val Gln Ser
    370                 375                 380                 
Gln Lys Val Val Gln Ala Val Ser Thr Asp Pro Val Pro Val Lys Leu
385                 390                 395                 400 
His Tyr Asp Lys Ser His Asp Gln Val Trp Val Leu Ser Trp Gly Thr
                405                 410                 415     
Leu Glu Lys Thr Ser Pro Thr Leu Gln Val Ile Thr Leu Ala Ser Gly
            420                 425                 430         
Asn Val Pro His His Thr Ile His Thr Gln Pro Val Gly Lys Gln Phe
        435                 440                 445             
Asp Arg Val Asp Asp Phe Phe Ile Pro Thr Thr Thr Leu Ile Ile Thr
    450                 455                 460                 
His Met Arg Phe Gly Phe Ile Leu His Lys Asp Glu Ala Ala Leu Gln
465                 470                 475                 480 
Lys Ile Asp Leu Glu Thr Met Ser Tyr Ile Lys Thr Ile Asn Leu Lys
                485                 490                 495     
Asp Tyr Lys Cys Val Pro Gln Ser Leu Ala Tyr Thr His Leu Gly Gly
            500                 505                 510         
Tyr Tyr Phe Ile Gly Cys Lys Pro Asp Ser Thr Gly Ala Val Ser Pro
        515                 520                 525             
Gln Val Met Val Asp Gly Val Thr Asp Ser Val Ile Gly Phe Asn Ser
    530                 535                 540                 
Asp Val Thr Gly Thr Pro Tyr Val Ser Pro Asp Gly His Tyr Leu Val
545                 550                 555                 560 
Ser Ile Asn Asp Val Lys Gly Leu Val Arg Val Gln Tyr Ile Thr Ile
                565                 570                 575     
Arg Gly Glu Ile Gln Glu Ala Phe Asp Ile Tyr Thr Asn Leu His Ile
            580                 585                 590         
Ser Asp Leu Ala Phe Gln Pro Ser Phe Thr Glu Ala His Gln Tyr Asn
        595                 600                 605             
Ile Tyr Gly Ser Ser Ser Thr Gln Thr Asp Val Leu Phe Val Glu Leu
    610                 615                 620                 
Ser Ser Gly Lys Val Lys Met Ile Lys Ser Leu Lys Glu Pro Leu Lys
625                 630                 635                 640 
Ala Glu Glu Trp Pro Trp Asn Arg Lys Asn Arg Gln Ile Gln Asp Ser
                645                 650                 655     
Gly Leu Phe Gly Gln Tyr Leu Met Thr Pro Ser Lys Asp Ser Leu Phe
            660                 665                 670         
Ile Leu Asp Gly Arg Leu Asn Lys Leu Asn Cys Glu Ile Thr Glu Val
        675                 680                 685             
Glu Lys Gly Asn Thr Val Ile Trp Val Gly Asp Ala
    690                 695                 700 


<210> 2426
<211> 428
<212> PRT
<213> Homo sapiens

<400> 2426
Met Ser Tyr Tyr Leu Ser Ser Glu Asn His Leu Asp Pro Gly Pro Ile
 1               5                  10                  15      
Tyr Met Arg Glu Asn Gly Gln Leu His Met Val Asn Leu Ala Leu Asp
            20                  25                  30          
Gly Val Arg Ser Ser Leu Gln Lys Pro Arg Pro Phe Arg Leu Phe Pro
        35                  40                  45              
Lys Gly Phe Ser Val Glu Leu Cys Met Asn Arg Glu Asp Asp Thr Ala
    50                  55                  60                  
Arg Lys Glu Lys Thr Asp His Phe Ile Phe Thr Tyr Thr Arg Glu Gly
65                  70                  75                  80  
Asn Leu Arg Tyr Ser Ala Lys Ser Leu Phe Ser Leu Val Leu Gly Phe
                85                  90                  95      
Ile Ser Asp Asn Val Asp His Ile Asp Ser Leu Ile Gly Phe Pro Glu
            100                 105                 110         
Gln Ile Ala Glu Lys Leu Phe Ser Ala Ala Glu Ala Arg Gln Lys Phe
        115                 120                 125             
Thr Glu Pro Gly Ala Gly Leu Arg Ala Leu Gln Lys Phe Thr Glu Ala
    130                 135                 140                 
Tyr Gly Ser Leu Val Leu Cys Ser Leu Cys Leu Arg Asn Arg Tyr Leu
145                 150                 155                 160 
Val Ile Ser Glu Lys Leu Glu Glu Ile Lys Ser Phe Arg Glu Leu Thr
                165                 170                 175     
Cys Leu Asp Leu Ser Cys Cys Lys Leu Gly Asp Glu His Glu Leu Leu
            180                 185                 190         
Glu His Leu Thr Asn Glu Ala Leu Ser Ser Val Thr Gln Leu His Leu
        195                 200                 205             
Lys Asp Asn Cys Leu Ser Asp Ala Gly Val Arg Lys Met Thr Ala Pro
    210                 215                 220                 
Val Arg Val Met Lys Arg Gly Leu Glu Asn Leu Thr Leu Leu Asp Leu
225                 230                 235                 240 
Ser Cys Asn Pro Glu Ile Thr Asp Ala Gly Ile Gly Tyr Leu Phe Ser
                245                 250                 255     
Phe Arg Lys Leu Asn Cys Leu Asp Ile Ser Gly Thr Gly Leu Lys Asp
            260                 265                 270         
Ile Lys Thr Val Lys His Lys Leu Gln Thr His Ile Gly Leu Val His
        275                 280                 285             
Ser Lys Val Pro Leu Lys Glu Phe Asp His Ser Asn Cys Lys Thr Glu
    290                 295                 300                 
Gly Trp Ala Asp Gln Ile Val Leu Gln Trp Glu Arg Val Thr Ala Glu
305                 310                 315                 320 
Ala Val Lys Pro Arg Glu Thr Ser Glu Pro Arg Ala Ala Ala Gln Arg
                325                 330                 335     
Phe Tyr Gly Lys Arg Ser Arg Ala Glu Ala Pro Leu Lys Cys Pro Leu
            340                 345                 350         
Ala Asp Thr His Met Asn Ser Ser Glu Lys Leu Gln Phe Tyr Lys Glu
        355                 360                 365             
Lys Ala Pro Asp Cys His Gly Pro Val Leu Lys His Glu Ala Ile Ser
    370                 375                 380                 
Ser Gln Glu Ser Lys Lys Ser Lys Lys Arg Pro Phe Glu Glu Ser Glu
385                 390                 395                 400 
Thr Glu Gln Asn Asn Ser Ser Gln Pro Ser Lys Gln Lys Tyr Val Cys
                405                 410                 415     
Leu Ala Val Glu Asp Trp Asp Leu Leu Asn Ser Tyr
            420                 425             


<210> 2427
<211> 658
<212> PRT
<213> Homo sapiens

<400> 2427
Met Val Pro Arg Leu Leu Leu Arg Ala Trp Pro Arg Gly Pro Ala Val
 1               5                  10                  15      
Gly Pro Gly Ala Pro Ser Arg Pro Val Ser Ala Gly Ser Gly Pro Gly
            20                  25                  30          
Gln Tyr Leu Gln Arg Ser Ile Val Pro Thr Met His Tyr Gln Asp Ser
        35                  40                  45              
Leu Pro Arg Leu Pro Ile Pro Lys Leu Glu Asp Thr Ile Arg Arg Tyr
    50                  55                  60                  
Leu Ser Ala Gln Lys Pro Leu Leu Asn Asp Gly Gln Phe Arg Lys Thr
65                  70                  75                  80  
Glu Gln Phe Cys Lys Ser Phe Glu Asn Gly Ile Gly Lys Glu Leu His
                85                  90                  95      
Glu Gln Leu Val Ala Leu Asp Lys Gln Asn Lys His Thr Ser Tyr Ile
            100                 105                 110         
Ser Gly Pro Trp Phe Asp Met Tyr Leu Ser Ala Arg Asp Ser Val Val
        115                 120                 125             
Leu Asn Phe Asn Pro Phe Met Ala Phe Asn Pro Asp Pro Lys Ser Glu
    130                 135                 140                 
Tyr Asn Asp Gln Leu Thr Arg Ala Thr Asn Met Thr Val Ser Ala Ile
145                 150                 155                 160 
Arg Phe Leu Lys Thr Leu Arg Ala Gly Leu Leu Glu Pro Glu Val Phe
                165                 170                 175     
His Leu Asn Pro Ala Lys Ser Asp Thr Ile Thr Phe Lys Arg Leu Ile
            180                 185                 190         
Arg Phe Val Pro Ser Ser Leu Ser Trp Tyr Gly Ala Tyr Leu Val Asn
        195                 200                 205             
Ala Tyr Pro Leu Asp Met Ser Gln Tyr Phe Arg Leu Phe Asn Ser Thr
    210                 215                 220                 
Arg Leu Pro Lys Pro Ser Arg Asp Glu Leu Phe Thr Asp Asp Lys Ala
225                 230                 235                 240 
Arg His Leu Leu Val Leu Arg Lys Gly Asn Phe Tyr Ile Phe Asp Val
                245                 250                 255     
Leu Asp Gln Asp Gly Asn Ile Val Ser Pro Ser Glu Ile Gln Ala His
            260                 265                 270         
Leu Lys Tyr Ile Leu Ser Asp Ser Ser Pro Ala Pro Glu Phe Pro Leu
        275                 280                 285             
Ala Tyr Leu Thr Ser Glu Asn Arg Asp Ile Trp Ala Glu Leu Arg Gln
    290                 295                 300                 
Lys Leu Met Ser Ser Gly Asn Glu Glu Ser Leu Arg Lys Val Asp Ser
305                 310                 315                 320 
Ala Val Phe Cys Leu Cys Leu Asp Asp Phe Pro Ile Lys Asp Leu Val
                325                 330                 335     
His Leu Ser His Asn Met Leu His Gly Asp Gly Thr Asn Arg Trp Phe
            340                 345                 350         
Asp Lys Ser Phe Asn Leu Ile Ile Ala Lys Asp Gly Ser Thr Ala Val
        355                 360                 365             
His Phe Glu His Ser Trp Gly Asp Gly Val Ala Val Leu Arg Phe Phe
    370                 375                 380                 
Asn Glu Val Phe Lys Asp Ser Thr Gln Thr Pro Ala Val Thr Pro Gln
385                 390                 395                 400 
Ser Gln Pro Ala Thr Thr Asp Ser Thr Val Thr Val Gln Lys Leu Asn
                405                 410                 415     
Phe Glu Leu Thr Asp Ala Leu Lys Thr Gly Ile Thr Ala Ala Lys Glu
            420                 425                 430         
Lys Phe Asp Ala Thr Met Lys Thr Leu Thr Ile Asp Cys Val Gln Phe
        435                 440                 445             
Gln Arg Gly Gly Lys Glu Phe Leu Lys Lys Gln Lys Leu Ser Pro Asp
    450                 455                 460                 
Ala Val Ala Gln Leu Ala Phe Gln Met Ala Phe Leu Arg Gln Tyr Gly
465                 470                 475                 480 
Gln Thr Val Ala Thr Tyr Glu Ser Cys Ser Thr Ala Ala Phe Lys His
                485                 490                 495     
Gly Arg Thr Glu Thr Ile Arg Pro Ala Ser Val Tyr Thr Lys Arg Cys
            500                 505                 510         
Ser Glu Ala Phe Val Arg Glu Pro Ser Arg His Ser Ala Gly Glu Leu
        515                 520                 525             
Gln Gln Met Met Val Glu Cys Ser Lys Tyr His Gly Gln Leu Thr Lys
    530                 535                 540                 
Glu Ala Ala Met Gly Gln Gly Phe Asp Arg His Leu Phe Ala Leu Arg
545                 550                 555                 560 
His Leu Ala Ala Ala Lys Gly Ile Ile Leu Pro Glu Leu Tyr Leu Asp
                565                 570                 575     
Pro Ala Tyr Gly Gln Ile Asn His Asn Val Leu Ser Thr Ser Thr Leu
            580                 585                 590         
Ser Ser Pro Ala Val Asn Leu Gly Gly Phe Ala Pro Val Val Ser Asp
        595                 600                 605             
Gly Phe Gly Val Gly Tyr Ala Val His Asp Asn Trp Ile Gly Cys Asn
    610                 615                 620                 
Val Ser Ser Tyr Pro Gly Arg Asn Ala Arg Glu Phe Leu Gln Cys Val
625                 630                 635                 640 
Glu Lys Ala Leu Glu Asp Met Phe Asp Ala Leu Glu Gly Lys Ser Ile
                645                 650                 655     
Lys Ser
        


<210> 2428
<211> 194
<212> PRT
<213> Homo sapiens

<400> 2428
Met Phe Ser Thr Ser Ala Lys Ile Val Lys Pro Asn Gly Glu Lys Pro
 1               5                  10                  15      
Asp Glu Phe Glu Ser Arg Ile Ser Gln Ala Leu Leu Glu Leu Glu Met
            20                  25                  30          
Asn Leu Asp Leu Lys Ala Gln Leu Arg Glu Leu Asn Ile Met Ala Ala
        35                  40                  45              
Lys Glu Ile Glu Val Gly Gly Gly Gln Lys Ala Ile Ile Ile Phe Val
    50                  55                  60                  
Pro Val Pro Gln Leu Lys Ser Phe Gln Lys Ile Gln Val Arg Leu Val
65                  70                  75                  80  
Cys Glu Leu Glu Lys Lys Phe Ser Gly Lys His Val Val Phe Ile Ala
                85                  90                  95      
Gln Arg Arg Ile Leu Pro Lys Pro Thr Trp Lys Ser Cys Thr Lys Tyr
            100                 105                 110         
Lys Gln Lys His Pro Arg Ser His Thr Leu Thr Ala Val His Asp Ala
        115                 120                 125             
Ile Leu Glu Asp Leu Val Phe Thr Ser Lys Ile Val Gly Lys Arg Ile
    130                 135                 140                 
Arg Val Lys Leu Asp Gly Ser Arg Leu Met Lys Val His Leu Asp Lys
145                 150                 155                 160 
Ala Gln Gln Asn Asn Val Glu His Lys Val Glu Thr Phe Ser Gly Val
                165                 170                 175     
Tyr Lys Lys Leu Met Gly Lys Asp Val Asn Phe Glu Phe Pro Glu Phe
            180                 185                 190         
Gln Leu
        


<210> 2429
<211> 90
<212> PRT
<213> Homo sapiens

<400> 2429
Met Ala Cys Pro Leu Asp Gln Ala Ile Gly Leu Leu Val Ala Val Phe
 1               5                  10                  15      
His Lys Tyr Ser Gly Met Glu Gly Asp Lys His Thr Leu Ser Lys Asn
            20                  25                  30          
Glu Leu Lys Glu Leu Ile Gln Lys Glu Leu Thr Ile Gly Ser Lys Leu
        35                  40                  45              
Gln Asp Ala Glu Ile Ala Arg Leu Met Glu Asp Leu Asp Arg Asn Lys
    50                  55                  60                  
Asp Gln Glu Val Asn Phe Gln Glu Tyr Val Thr Phe Val Gly Ala Leu
65                  70                  75                  80  
Ala Leu Ile Tyr Asn Glu Ala Leu Lys Gly
                85                  90  


<210> 2430
<211> 137
<212> PRT
<213> Homo sapiens

<400> 2430
Met Glu Val Leu Glu Met Arg Ala Lys Asn Pro Gly Pro Gln Leu Arg
 1               5                  10                  15      
Lys Phe Lys Thr Asn Val Leu Pro Phe Arg Gln Asn Asp Ser Ser Ser
            20                  25                  30          
His Cys Gln Lys Ser Gly Ser Pro Ile Ser Ser Lys Glu Arg Arg Arg
        35                  40                  45              
Arg Asp Lys Gln His Leu Asp Asp Ile Thr Ala Ala Arg Leu Leu Pro
    50                  55                  60                  
Leu His His Met Pro Thr Gln Leu Leu Ser Ile Glu Glu Ser Leu Ala
65                  70                  75                  80  
Leu Gln Lys Gln Gln Lys Gln Asn Tyr Glu Glu Met Gln Ala Lys Leu
                85                  90                  95      
Ala Ala Gln Lys Leu Ala Glu Arg Pro Asn Ile Lys Met Arg Ser Tyr
            100                 105                 110         
Asn Pro Glu Gly Glu Ser Ser Gly Arg Tyr Arg Glu Val Arg Asp Glu
        115                 120                 125             
Asp Asp Asp Trp Ser Ser Asp Glu Phe
    130                 135         


<210> 2431
<211> 1630
<212> PRT
<213> Homo sapiens

<400> 2431
Met Thr Thr Thr Val Ala Thr Asp Tyr Asp Asn Ile Glu Ile Gln Gln
 1               5                  10                  15      
Gln Tyr Ser Asp Val Asn Asn Arg Trp Asp Val Asp Asp Trp Asp Asn
            20                  25                  30          
Glu Asn Ser Ser Ala Arg Leu Phe Glu Arg Ser Arg Ile Lys Ala Leu
        35                  40                  45              
Ala Asp Glu Arg Glu Ala Val Gln Lys Lys Thr Phe Thr Lys Trp Val
    50                  55                  60                  
Asn Ser His Leu Ala Arg Val Ser Cys Arg Ile Thr Asp Leu Tyr Thr
65                  70                  75                  80  
Asp Leu Arg Asp Gly Arg Met Leu Ile Lys Leu Leu Glu Val Leu Ser
                85                  90                  95      
Gly Glu Arg Leu Pro Lys Pro Thr Lys Gly Arg Met Arg Ile His Cys
            100                 105                 110         
Leu Glu Asn Val Asp Lys Ala Leu Gln Phe Leu Lys Glu Gln Arg Val
        115                 120                 125             
His Leu Glu Asn Met Gly Ser His Asp Ile Val Asp Gly Asn His Arg
    130                 135                 140                 
Leu Thr Leu Gly Leu Ile Trp Thr Ile Ile Leu Arg Phe Gln Ile Gln
145                 150                 155                 160 
Asp Ile Ser Val Glu Thr Glu Asp Asn Lys Glu Lys Lys Ser Ala Lys
                165                 170                 175     
Asp Ala Leu Leu Leu Trp Cys Gln Met Lys Thr Ala Gly Tyr Pro Asn
            180                 185                 190         
Val Asn Ile His Asn Phe Thr Thr Ser Trp Arg Asp Gly Met Ala Phe
        195                 200                 205             
Asn Ala Leu Ile His Lys His Arg Pro Asp Leu Ile Asp Phe Asp Lys
    210                 215                 220                 
Leu Lys Lys Ser Asn Ala His Tyr Asn Leu Gln Asn Ala Phe Asn Leu
225                 230                 235                 240 
Ala Glu Gln His Leu Gly Leu Thr Lys Leu Leu Asp Pro Glu Asp Ile
                245                 250                 255     
Ser Val Asp His Pro Asp Glu Lys Ser Ile Ile Thr Tyr Val Val Thr
            260                 265                 270         
Tyr Tyr His Tyr Phe Ser Lys Met Lys Ala Leu Ala Val Glu Gly Lys
        275                 280                 285             
Arg Ile Gly Lys Val Leu Asp Asn Ala Ile Glu Thr Glu Lys Met Ile
    290                 295                 300                 
Glu Lys Tyr Glu Ser Leu Ala Ser Asp Leu Leu Glu Trp Ile Glu Gln
305                 310                 315                 320 
Thr Ile Ile Ile Leu Asn Asn Arg Lys Phe Ala Asn Ser Leu Val Gly
                325                 330                 335     
Val Gln Gln Gln Leu Gln Ala Phe Asn Thr Tyr Arg Thr Val Glu Lys
            340                 345                 350         
Pro Pro Lys Phe Thr Glu Lys Gly Asn Leu Glu Val Leu Leu Phe Thr
        355                 360                 365             
Ile Gln Ser Lys Met Arg Ala Asn Asn Gln Lys Val Tyr Met Pro Arg
    370                 375                 380                 
Glu Gly Lys Leu Ile Ser Asp Ile Asn Lys Ala Trp Glu Arg Leu Glu
385                 390                 395                 400 
Lys Ala Glu His Glu Arg Glu Leu Ala Leu Arg Asn Glu Leu Ile Arg
                405                 410                 415     
Gln Glu Lys Leu Glu Gln Leu Ala Arg Arg Phe Asp Arg Lys Ala Ala
            420                 425                 430         
Met Arg Glu Thr Trp Leu Ser Glu Asn Gln Arg Leu Val Ser Gln Asp
        435                 440                 445             
Asn Phe Gly Phe Asp Leu Pro Ala Val Glu Ala Ala Thr Lys Lys His
    450                 455                 460                 
Glu Ala Ile Glu Thr Asp Ile Ala Ala Tyr Glu Glu Arg Val Gln Ala
465                 470                 475                 480 
Val Val Ala Val Ala Arg Glu Leu Glu Ala Glu Asn Tyr His Asp Ile
                485                 490                 495     
Lys Arg Ile Thr Ala Arg Lys Asp Asn Val Ile Arg Leu Trp Glu Tyr
            500                 505                 510         
Leu Leu Glu Leu Leu Arg Ala Arg Arg Gln Arg Leu Glu Met Asn Leu
        515                 520                 525             
Gly Leu Gln Lys Ile Phe Gln Glu Met Leu Tyr Ile Met Asp Trp Met
    530                 535                 540                 
Asp Glu Met Lys Val Leu Val Leu Ser Gln Asp Tyr Gly Lys His Leu
545                 550                 555                 560 
Leu Gly Val Glu Asp Leu Leu Gln Lys His Thr Leu Val Glu Ala Asp
                565                 570                 575     
Ile Gly Ile Gln Ala Glu Arg Val Arg Gly Val Asn Ala Ser Ala Gln
            580                 585                 590         
Lys Phe Ala Thr Asp Gly Glu Gly Tyr Lys Pro Cys Asp Pro Gln Val
        595                 600                 605             
Ile Arg Asp Arg Val Ala His Met Glu Phe Cys Tyr Gln Glu Leu Cys
    610                 615                 620                 
Gln Leu Ala Ala Glu Arg Arg Ala Arg Leu Glu Glu Ser Arg Arg Leu
625                 630                 635                 640 
Trp Lys Phe Phe Trp Glu Met Ala Glu Glu Glu Gly Trp Ile Arg Glu
                645                 650                 655     
Lys Glu Lys Ile Leu Ser Ser Asp Asp Tyr Gly Lys Asp Leu Thr Ser
            660                 665                 670         
Val Met Arg Leu Leu Ser Lys His Arg Ala Phe Glu Asp Glu Met Ser
        675                 680                 685             
Gly Arg Ser Gly His Phe Glu Gln Ala Ile Lys Glu Gly Glu Asp Met
    690                 695                 700                 
Ile Ala Glu Glu His Phe Gly Ser Glu Lys Ile Arg Glu Arg Ile Ile
705                 710                 715                 720 
Tyr Ile Arg Glu Gln Trp Ala Asn Leu Glu Gln Leu Ser Ala Ile Arg
                725                 730                 735     
Lys Lys Arg Leu Glu Glu Ala Ser Leu Leu His Gln Phe Gln Ala Asp
            740                 745                 750         
Ala Asp Asp Ile Asp Ala Trp Met Leu Asp Ile Leu Lys Ile Val Ser
        755                 760                 765             
Ser Ser Asp Val Gly His Asp Glu Tyr Ser Thr Gln Ser Leu Val Lys
    770                 775                 780                 
Lys His Lys Asp Val Ala Glu Glu Ile Ala Asn Tyr Arg Pro Thr Leu
785                 790                 795                 800 
Asp Thr Leu His Glu Gln Ala Ser Ala Leu Pro Gln Glu His Ala Glu
                805                 810                 815     
Ser Pro Asp Val Arg Gly Arg Leu Ser Gly Ile Glu Glu Arg Tyr Lys
            820                 825                 830         
Glu Val Ala Glu Leu Thr Arg Leu Arg Lys Gln Ala Leu Gln Asp Thr
        835                 840                 845             
Leu Ala Leu Tyr Lys Met Phe Ser Glu Ala Asp Ala Cys Glu Leu Trp
    850                 855                 860                 
Ile Asp Glu Lys Glu Gln Trp Leu Asn Asn Met Gln Ile Pro Glu Lys
865                 870                 875                 880 
Leu Glu Asp Leu Glu Val Ile Gln His Arg Phe Glu Ser Leu Glu Pro
                885                 890                 895     
Glu Met Asn Asn Gln Ala Ser Arg Val Ala Val Val Asn Gln Ile Ala
            900                 905                 910         
Arg Gln Leu Met His Ser Gly His Pro Ser Glu Lys Glu Ile Lys Ala
        915                 920                 925             
Gln Gln Asp Lys Leu Asn Thr Arg Trp Ser Gln Phe Arg Glu Leu Val
    930                 935                 940                 
Asp Arg Lys Lys Asp Ala Leu Leu Ser Ala Leu Ser Ile Gln Asn Tyr
945                 950                 955                 960 
His Leu Glu Cys Asn Glu Thr Lys Ser Trp Ile Arg Glu Lys Thr Lys
                965                 970                 975     
Val Ile Glu Ser Thr Gln Asp Leu Gly Asn Asp Leu Ala Gly Val Met
            980                 985                 990         
Ala Leu Gln Arg Lys Leu Thr Gly Met Glu Arg Asp Leu Val Ala Ile
        995                 1000                1005            
Glu Ala Lys Leu Ser Asp Leu Gln Lys Glu Ala Glu Lys Leu Glu Ser
    1010                1015                1020                
Glu His Pro Asp Gln Ala Gln Ala Ile Leu Ser Arg Leu Ala Glu Ile
1025                1030                1035                1040
Ser Asp Val Trp Glu Glu Met Lys Thr Thr Leu Lys Asn Arg Glu Ala
                1045                1050                1055    
Ser Leu Gly Glu Ala Ser Lys Leu Gln Gln Phe Leu Arg Asp Leu Asp
            1060                1065                1070        
Asp Phe Gln Ser Trp Leu Ser Arg Thr Gln Thr Ala Ile Ala Ser Glu
        1075                1080                1085            
Asp Met Pro Asn Thr Leu Thr Glu Ala Glu Lys Leu Leu Thr Gln His
    1090                1095                1100                
Glu Asn Ile Lys Asn Glu Ile Asp Asn Tyr Glu Glu Asp Tyr Gln Lys
1105                1110                1115                1120
Met Arg Asp Met Gly Glu Met Val Thr Gln Gly Gln Thr Asp Ala Gln
                1125                1130                1135    
Tyr Met Phe Leu Arg Gln Arg Leu Gln Ala Leu Asp Thr Gly Trp Asn
            1140                1145                1150        
Glu Leu His Lys Met Trp Glu Asn Arg Gln Asn Leu Leu Ser Gln Ser
        1155                1160                1165            
His Ala Tyr Gln Gln Phe Leu Arg Asp Thr Lys Gln Ala Glu Ala Phe
    1170                1175                1180                
Leu Asn Asn Gln Glu Tyr Val Leu Ala His Thr Glu Met Pro Thr Thr
1185                1190                1195                1200
Leu Glu Gly Ala Glu Ala Ala Ile Lys Lys Gln Glu Asp Phe Met Thr
                1205                1210                1215    
Thr Met Asp Ala Asn Glu Glu Lys Ile Asn Ala Val Val Glu Thr Gly
            1220                1225                1230        
Arg Arg Leu Val Ser Asp Gly Asn Ile Asn Ser Asp Arg Ile Gln Glu
        1235                1240                1245            
Lys Val Asp Ser Ile Asp Asp Arg His Arg Lys Asn Arg Glu Thr Ala
    1250                1255                1260                
Ser Glu Leu Leu Met Arg Leu Lys Asp Asn Arg Asp Leu Gln Lys Phe
1265                1270                1275                1280
Leu Gln Asp Cys Gln Glu Leu Ser Leu Trp Ile Asn Glu Lys Met Leu
                1285                1290                1295    
Thr Ala Gln Asp Met Ser Tyr Asp Glu Ala Arg Asn Leu His Ser Lys
            1300                1305                1310        
Trp Leu Lys His Gln Ala Phe Met Ala Glu Leu Ala Ser Asn Lys Glu
        1315                1320                1325            
Trp Leu Asp Lys Ile Glu Lys Glu Gly Met Gln Leu Ile Ser Glu Lys
    1330                1335                1340                
Pro Glu Thr Glu Ala Val Val Lys Glu Lys Leu Thr Gly Leu His Lys
1345                1350                1355                1360
Met Trp Glu Val Leu Glu Ser Thr Thr Gln Thr Lys Ala Gln Arg Leu
                1365                1370                1375    
Phe Asp Ala Asn Lys Ala Glu Leu Phe Thr Gln Ser Cys Ala Asp Leu
            1380                1385                1390        
Asp Lys Trp Leu His Gly Leu Glu Ser Gln Ile Gln Ser Asp Asp Tyr
        1395                1400                1405            
Gly Lys Asp Leu Thr Ser Val Asn Ile Leu Leu Lys Lys Gln Gln Met
    1410                1415                1420                
Leu Glu Asn Gln Met Glu Val Arg Lys Lys Glu Ile Glu Glu Leu Gln
1425                1430                1435                1440
Ser Gln Ala Gln Ala Leu Ser Gln Glu Gly Lys Ser Thr Asp Glu Val
                1445                1450                1455    
Asp Ser Lys Arg Leu Thr Val Gln Thr Lys Phe Met Glu Leu Leu Glu
            1460                1465                1470        
Pro Leu Asn Glu Arg Lys His Asn Leu Leu Ala Ser Lys Glu Ile His
        1475                1480                1485            
Gln Phe Asn Arg Asp Val Glu Asp Glu Ile Leu Trp Val Gly Glu Arg
    1490                1495                1500                
Met Pro Leu Ala Thr Ser Thr Asp His Gly His Asn Leu Gln Thr Val
1505                1510                1515                1520
Gln Leu Leu Ile Lys Lys Asn Gln Thr Leu Gln Lys Glu Ile Gln Gly
                1525                1530                1535    
His Gln Pro Arg Ile Asp Asp Ile Phe Glu Arg Ser Gln Asn Ile Val
            1540                1545                1550        
Thr Asp Ser Ser Ser Leu Ser Ala Glu Ala Ile Arg Gln Arg Leu Ala
        1555                1560                1565            
Asp Leu Lys Gln Leu Trp Gly Leu Leu Ile Glu Glu Thr Glu Lys Arg
    1570                1575                1580                
His Arg Arg Leu Glu Glu Ala His Arg Ala Gln Gln Tyr Tyr Phe Asp
1585                1590                1595                1600
Ala Ala Glu Ala Glu Ala Trp Met Ser Glu Gln Glu Leu Tyr Met Met
                1605                1610                1615    
Ser Glu Glu Lys Ala Lys Met Ser Arg Val Leu Ser Pro Cys
            1620                1625                1630


<210> 2432
<211> 118
<212> PRT
<213> Homo sapiens

<400> 2432
Met Ala Ala Pro Pro Glu Pro Gly Glu Pro Glu Glu Arg Lys Ser Leu
 1               5                  10                  15      
Lys Leu Leu Gly Phe Leu Asp Val Glu Asn Thr Pro Cys Ala Arg His
            20                  25                  30          
Ser Ile Leu Tyr Gly Ser Leu Gly Ser Val Val Ala Gly Phe Gly His
        35                  40                  45              
Phe Leu Phe Thr Ser Arg Ile Arg Arg Ser Cys Asp Val Gly Val Gly
    50                  55                  60                  
Gly Phe Ile Leu Val Thr Leu Gly Cys Trp Phe His Cys Arg Tyr Asn
65                  70                  75                  80  
Tyr Ala Lys Gln Arg Ile Gln Glu Arg Ile Ala Arg Glu Glu Ile Lys
                85                  90                  95      
Lys Lys Ile Leu Tyr Glu Gly Thr His Leu Asp Pro Glu Arg Lys His
            100                 105                 110         
Asn Gly Ser Ser Ser Asn
        115             


<210> 2433
<211> 371
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 165
<223> Xaa = Any Amino Acid

<400> 2433
Met Ser Phe Arg Lys Val Asn Ile Ile Ile Leu Val Leu Ala Val Ala
 1               5                  10                  15      
Leu Phe Leu Leu Val Leu His His Asn Phe Leu Ser Leu Ser Ser Leu
            20                  25                  30          
Leu Arg Asn Glu Val Thr Asp Ser Gly Ile Val Gly Pro Gln Pro Ile
        35                  40                  45              
Asp Phe Val Pro Asn Ala Leu Arg His Ala Val Asp Gly Arg Gln Glu
    50                  55                  60                  
Glu Ile Pro Val Val Ile Ala Ala Ser Glu Asp Arg Leu Gly Gly Ala
65                  70                  75                  80  
Ile Ala Ala Ile Asn Ser Ile Gln His Asn Thr Arg Ser Asn Val Ile
                85                  90                  95      
Phe Tyr Ile Val Thr Leu Asn Asn Thr Ala Asp His Leu Arg Ser Trp
            100                 105                 110         
Leu Asn Ser Asp Ser Leu Lys Ser Ile Arg Tyr Lys Ile Val Asn Phe
        115                 120                 125             
Asp Pro Lys Leu Leu Glu Gly Lys Val Lys Glu Asp Pro Asp Gln Gly
    130                 135                 140                 
Glu Ser Met Lys Pro Leu Thr Phe Ala Arg Phe Tyr Leu Pro Ile Leu
145                 150                 155                 160 
Val Pro Ser Ala Xaa Lys Ala Ile Tyr Met Asp Asp Asp Val Ile Val
                165                 170                 175     
Gln Gly Asp Ile Leu Ala Leu Tyr Asn Thr Ala Leu Lys Pro Gly His
            180                 185                 190         
Ala Ala Ala Phe Ser Glu Asp Cys Asp Ser Ala Ser Thr Lys Val Val
        195                 200                 205             
Ile Arg Gly Ala Gly Asn Gln Tyr Asn Tyr Ile Gly Tyr Leu Asp Tyr
    210                 215                 220                 
Lys Lys Glu Arg Ile Arg Lys Leu Ser Met Lys Ala Ser Thr Cys Ser
225                 230                 235                 240 
Phe Asn Pro Gly Val Phe Val Ala Asn Leu Thr Glu Trp Lys Arg Gln
                245                 250                 255     
Asn Ile Thr Asn Gln Leu Glu Lys Trp Met Lys Leu Asn Val Glu Glu
            260                 265                 270         
Gly Leu Tyr Ser Arg Thr Leu Ala Gly Ser Ile Thr Thr Pro Pro Leu
        275                 280                 285             
Leu Ile Val Phe Tyr Gln Gln His Ser Thr Ile Asp Pro Met Trp Asn
    290                 295                 300                 
Val Arg His Leu Gly Ser Ser Ala Gly Lys Arg Tyr Ser Pro Gln Phe
305                 310                 315                 320 
Val Lys Ala Ala Lys Leu Leu His Trp Asn Gly His Leu Lys Pro Trp
                325                 330                 335     
Gly Arg Thr Ala Ser Tyr Thr Asp Val Trp Glu Lys Trp Tyr Ile Pro
            340                 345                 350         
Asp Pro Thr Gly Lys Phe Asn Leu Ile Arg Arg Tyr Thr Glu Ile Ser
        355                 360                 365             
Asn Ile Lys
    370     


<210> 2434
<211> 573
<212> PRT
<213> Homo sapiens

<400> 2434
Met Ser Ser Ala Ala Glu Asn Gly Glu Ala Ala Pro Gly Lys Gln Asn
 1               5                  10                  15      
Glu Glu Lys Thr Tyr Lys Lys Thr Ala Ser Ser Ala Ile Lys Gly Ala
            20                  25                  30          
Ile Gln Leu Gly Ile Gly Tyr Thr Val Gly Asn Leu Thr Ser Lys Pro
        35                  40                  45              
Glu Arg Asp Val Leu Met Gln Asp Phe Tyr Val Val Glu Ser Val Phe
    50                  55                  60                  
Leu Pro Ser Glu Gly Ser Asn Leu Thr Pro Ala His His Tyr Pro Asp
65                  70                  75                  80  
Phe Arg Phe Lys Thr Tyr Ala Pro Leu Ala Phe Arg Tyr Phe Arg Glu
                85                  90                  95      
Leu Phe Gly Ile Lys Pro Asp Asp Tyr Leu Tyr Ser Ile Cys Ser Glu
            100                 105                 110         
Pro Leu Ile Glu Leu Ser Asn Pro Gly Ala Ser Gly Ser Leu Phe Phe
        115                 120                 125             
Val Thr Ser Asp Asp Glu Phe Ile Ile Lys Thr Val Gln His Lys Glu
    130                 135                 140                 
Ala Glu Phe Leu Gln Lys Leu Leu Pro Gly Tyr Tyr Met Asn Leu Asn
145                 150                 155                 160 
Gln Asn Pro Arg Thr Leu Leu Pro Lys Phe Tyr Gly Leu Tyr Cys Met
                165                 170                 175     
Gln Ser Gly Gly Ile Asn Ile Arg Ile Val Val Met Asn Asn Val Leu
            180                 185                 190         
Pro Arg Ser Met Arg Met His Phe Thr Tyr Asp Leu Lys Gly Ser Thr
        195                 200                 205             
Tyr Lys Arg Arg Ala Ser Arg Lys Glu Arg Glu Lys Ser Asn Pro Thr
    210                 215                 220                 
Phe Lys Asp Leu Asp Phe Leu Gln Asp Met His Glu Gly Leu Tyr Phe
225                 230                 235                 240 
Asp Thr Glu Thr Tyr Asn Ala Leu Met Lys Thr Leu Gln Arg Asp Cys
                245                 250                 255     
Arg Val Leu Glu Ser Phe Lys Ile Met Asp Tyr Ser Leu Leu Leu Gly
            260                 265                 270         
Ile His Phe Leu Asp His Ser Leu Lys Glu Lys Glu Glu Glu Thr Pro
        275                 280                 285             
Gln Asn Val Pro Asp Ala Lys Arg Thr Gly Met Gln Lys Val Leu Tyr
    290                 295                 300                 
Ser Thr Ala Met Glu Ser Ile Gln Gly Pro Gly Lys Ser Gly Asp Gly
305                 310                 315                 320 
Ile Ile Thr Glu Asn Pro Asp Thr Met Gly Gly Ile Pro Ala Lys Ser
                325                 330                 335     
His Arg Gly Glu Lys Leu Leu Leu Phe Met Gly Ile Ile Asp Ile Leu
            340                 345                 350         
Gln Ser Tyr Arg Leu Met Lys Lys Leu Glu His Ser Trp Lys Ala Leu
        355                 360                 365             
Val Tyr Asp Gly Asp Thr Val Ser Val His Arg Pro Ser Phe Tyr Ala
    370                 375                 380                 
Asp Arg Phe Leu Lys Phe Met Asn Ser Arg Val Phe Lys Lys Ile Gln
385                 390                 395                 400 
Ala Leu Lys Ala Ser Pro Ser Lys Lys Arg Cys Asn Ser Ile Ala Ala
                405                 410                 415     
Leu Lys Ala Thr Ser Gln Glu Ile Val Ser Ser Ile Ser Gln Glu Trp
            420                 425                 430         
Lys Asp Glu Lys Arg Asp Leu Leu Thr Glu Gly Gln Ser Phe Ser Ser
        435                 440                 445             
Leu Asp Glu Glu Ala Leu Gly Ser Arg His Arg Pro Asp Leu Val Pro
    450                 455                 460                 
Ser Thr Pro Ser Leu Phe Glu Ala Ala Ser Leu Ala Thr Thr Ile Ser
465                 470                 475                 480 
Ser Ser Ser Leu Tyr Val Asn Glu His Tyr Pro His Asp Arg Pro Thr
                485                 490                 495     
Leu Tyr Ser Asn Ser Lys Gly Leu Pro Ser Ser Ser Thr Phe Thr Leu
            500                 505                 510         
Glu Glu Gly Thr Ile Tyr Leu Thr Ala Glu Pro Asn Thr Leu Glu Val
        515                 520                 525             
Gln Asp Asp Asn Ala Ser Val Leu Asp Val Tyr Leu Val Ser Glu Asn
    530                 535                 540                 
Gly Asp His Leu Ser Thr Trp Met Arg Arg Glu His Ser Tyr Gly Arg
545                 550                 555                 560 
Glu Val Ser Pro His Gln Asn Tyr Pro Gln Gln Leu Gly
                565                 570             


<210> 2435
<211> 538
<212> PRT
<213> Homo sapiens

<400> 2435
Met Asn Leu Glu Leu Leu Glu Ser Phe Gly Gln Asn Tyr Pro Glu Glu
 1               5                  10                  15      
Ala Asp Gly Thr Leu Asp Cys Ile Ser Met Ala Leu Thr Cys Thr Phe
            20                  25                  30          
Asn Arg Trp Gly Thr Leu Leu Ala Val Gly Cys Asn Asp Gly Arg Ile
        35                  40                  45              
Val Ile Trp Asp Phe Leu Thr Arg Gly Ile Ala Lys Ile Ile Ser Ala
    50                  55                  60                  
His Ile His Pro Val Cys Ser Leu Cys Trp Ser Arg Asp Gly His Lys
65                  70                  75                  80  
Leu Val Ser Ala Ser Thr Asp Asn Ile Val Ser Gln Trp Asp Val Leu
                85                  90                  95      
Ser Gly Asp Cys Asp Gln Arg Phe Arg Phe Pro Ser Pro Ile Leu Lys
            100                 105                 110         
Val Gln Tyr His Pro Arg Asp Gln Asn Lys Val Leu Val Cys Pro Met
        115                 120                 125             
Lys Ser Ala Pro Val Met Leu Thr Leu Ser Asp Ser Lys His Val Val
    130                 135                 140                 
Leu Pro Val Asp Asp Asp Ser Asp Leu Asn Val Val Ala Ser Phe Asp
145                 150                 155                 160 
Arg Arg Gly Glu Tyr Ile Tyr Thr Gly Asn Ala Lys Gly Lys Ile Leu
                165                 170                 175     
Val Leu Lys Thr Asp Ser Gln Asp Leu Val Ala Ser Phe Arg Val Thr
            180                 185                 190         
Thr Gly Thr Ser Asn Thr Thr Ala Ile Lys Ser Ile Glu Phe Ala Arg
        195                 200                 205             
Lys Gly Ser Cys Phe Leu Ile Asn Thr Ala Asp Arg Ile Ile Arg Val
    210                 215                 220                 
Tyr Asp Gly Arg Glu Ile Leu Thr Cys Gly Arg Asp Gly Glu Pro Glu
225                 230                 235                 240 
Pro Met Gln Lys Leu Gln Asp Leu Val Asn Arg Thr Pro Trp Lys Lys
                245                 250                 255     
Cys Cys Phe Ser Gly Asp Gly Glu Tyr Ile Val Ala Gly Ser Ala Arg
            260                 265                 270         
Gln His Ala Leu Tyr Ile Trp Glu Lys Ser Ile Gly Asn Leu Val Lys
        275                 280                 285             
Ile Leu His Gly Thr Arg Gly Glu Leu Leu Leu Asp Val Ala Trp His
    290                 295                 300                 
Pro Val Arg Pro Ile Ile Ala Ser Ile Ser Ser Gly Val Val Ser Ile
305                 310                 315                 320 
Trp Ala Gln Asn Gln Val Glu Asn Trp Ser Ala Phe Ala Pro Asp Phe
                325                 330                 335     
Lys Glu Leu Asp Glu Asn Val Glu Tyr Glu Glu Arg Glu Ser Glu Phe
            340                 345                 350         
Asp Ile Glu Asp Glu Asp Lys Ser Glu Pro Glu Gln Thr Gly Ala Asp
        355                 360                 365             
Ala Ala Glu Asp Glu Glu Val Asp Val Thr Ser Val Asp Pro Ile Ala
    370                 375                 380                 
Ala Phe Cys Ser Ser Asp Glu Glu Leu Glu Asp Ser Lys Ala Leu Leu
385                 390                 395                 400 
Tyr Leu Pro Ile Ala Pro Glu Val Glu Asp Pro Glu Glu Asn Pro Tyr
                405                 410                 415     
Gly Pro Pro Pro Asp Ala Val Gln Thr Ser Leu Met Asp Glu Gly Ala
            420                 425                 430         
Ser Ser Glu Lys Lys Arg Gln Ser Ser Ala Asp Gly Ser Gln Pro Pro
        435                 440                 445             
Lys Lys Lys Pro Lys Thr Thr Asn Ile Glu Leu Gln Gly Val Pro Asn
    450                 455                 460                 
Asp Glu Val His Pro Leu Leu Gly Val Lys Gly Asp Gly Lys Ser Lys
465                 470                 475                 480 
Lys Lys Gln Ala Gly Arg Pro Lys Gly Ser Lys Gly Lys Glu Lys Asp
                485                 490                 495     
Ser Pro Phe Lys Pro Lys Leu Tyr Lys Gly Asp Arg Gly Leu Pro Leu
            500                 505                 510         
Glu Gly Ser Ala Lys Gly Lys Val Gln Ala Glu Leu Ser Gln Pro Leu
        515                 520                 525             
Thr Ala Gly Gly Ala Ile Ser Glu Leu Leu
    530                 535             


<210> 2436
<211> 3647
<212> PRT
<213> Homo sapiens

<400> 2436
Met Gly Ala Arg Ala Lys Thr Arg Ser Ser Ser Cys Glu Leu Met Met
 1               5                  10                  15      
Lys Trp Phe Cys Ser Ala Pro Gln Pro Ser Thr Lys Asn Asn Arg Ser
            20                  25                  30          
Tyr Ala Trp Gln Gln Lys Asp Leu Ala Thr Asp Phe Val Ser Trp Ser
        35                  40                  45              
Pro Leu Pro Ile Pro Arg Met Cys Pro Gln Thr Ser Pro Ser Ala Pro
    50                  55                  60                  
Leu Cys Trp Ser Ser Pro Ser Leu Ser Gly Arg Cys Arg Arg Cys Trp
65                  70                  75                  80  
Leu Thr Pro Trp Arg Asn Gln Lys Gly Gln Val Asp Val Glu Lys Trp
                85                  90                  95      
Lys Phe Met Met Lys Thr Ala Gln Gly Gly Gly His Arg Thr Leu Leu
            100                 105                 110         
Tyr Gly His Ala Ile Leu Leu Arg His Ser Tyr Ser Gly Met Tyr Leu
        115                 120                 125             
Cys Cys Leu Ser Thr Ser Arg Ser Ser Thr Asp Lys Leu Ala Phe Asp
    130                 135                 140                 
Val Gly Leu Gln Glu Asp Thr Thr Gly Glu Ala Cys Trp Trp Thr Ile
145                 150                 155                 160 
His Pro Ala Ser Lys Gln Arg Ser Glu Gly Glu Lys Val Arg Val Gly
                165                 170                 175     
Asp Asp Leu Ile Leu Val Ser Val Ser Ser Glu Arg Tyr Leu His Leu
            180                 185                 190         
Ser Tyr Gly Asn Gly Ser Leu His Val Asp Ala Ala Phe Gln Gln Thr
        195                 200                 205             
Leu Trp Ser Val Ala Pro Ile Ser Ser Gly Ser Glu Ala Ala Gln Gly
    210                 215                 220                 
Tyr Leu Ile Gly Gly Asp Val Leu Arg Leu Leu His Gly His Met Asp
225                 230                 235                 240 
Glu Cys Leu Thr Val Pro Ser Gly Glu His Gly Glu Glu Gln Arg Arg
                245                 250                 255     
Thr Val His Tyr Glu Gly Gly Ala Val Ser Val His Ala Arg Ser Leu
            260                 265                 270         
Trp Arg Leu Glu Thr Leu Arg Val Ala Trp Ser Gly Ser His Ile Arg
        275                 280                 285             
Trp Gly Gln Pro Phe Arg Leu Arg His Val Thr Thr Gly Lys Tyr Leu
    290                 295                 300                 
Ser Leu Met Glu Asp Lys Asn Leu Leu Leu Met Asp Lys Glu Lys Ala
305                 310                 315                 320 
Asp Val Lys Ser Thr Ala Phe Thr Phe Arg Ser Ser Lys Glu Lys Leu
                325                 330                 335     
Asp Val Gly Val Arg Lys Glu Val Asp Gly Met Gly Thr Ser Glu Ile
            340                 345                 350         
Lys Tyr Gly Asp Ser Val Cys Tyr Ile Gln His Val Asp Thr Gly Leu
        355                 360                 365             
Trp Leu Thr Tyr Gln Ser Val Asp Val Lys Ser Val Arg Met Gly Ser
    370                 375                 380                 
Ile Gln Arg Lys Ala Ile Met His His Glu Gly His Met Asp Asp Gly
385                 390                 395                 400 
Ile Ser Leu Ser Arg Ser Gln His Glu Glu Ser Arg Thr Ala Arg Val
                405                 410                 415     
Ile Arg Ser Thr Val Phe Leu Phe Asn Arg Phe Ile Arg Gly Leu Asp
            420                 425                 430         
Ala Leu Ser Lys Lys Ala Lys Ala Ser Thr Val Asp Leu Pro Ile Glu
        435                 440                 445             
Ser Val Ser Leu Ser Leu Gln Asp Leu Ile Gly Tyr Phe His Pro Pro
    450                 455                 460                 
Asp Glu His Leu Glu His Glu Asp Lys Gln Asn Arg Leu Arg Ala Leu
465                 470                 475                 480 
Lys Asn Arg Gln Asn Leu Phe Gln Glu Glu Gly Met Ile Asn Leu Val
                485                 490                 495     
Leu Glu Cys Ile Asp Arg Leu His Val Tyr Ser Ser Ala Ala His Phe
            500                 505                 510         
Ala Asp Val Ala Gly Arg Glu Ala Gly Glu Ser Trp Lys Ser Ile Leu
        515                 520                 525             
Asn Ser Leu Tyr Glu Leu Leu Ala Ala Leu Ile Arg Gly Asn Arg Lys
    530                 535                 540                 
Asn Cys Ala Gln Phe Ser Gly Ser Leu Asp Trp Leu Ile Ser Arg Leu
545                 550                 555                 560 
Glu Arg Leu Glu Ala Ser Ser Gly Ile Leu Glu Val Leu His Cys Val
                565                 570                 575     
Leu Val Glu Ser Pro Glu Ala Leu Asn Ile Ile Lys Glu Gly His Ile
            580                 585                 590         
Lys Ser Ile Ile Ser Leu Leu Asp Lys His Gly Arg Asn His Lys Val
        595                 600                 605             
Leu Asp Val Leu Cys Ser Leu Cys Val Cys His Gly Val Ala Val Arg
    610                 615                 620                 
Ser Asn Gln His Leu Ile Cys Asp Asn Leu Leu Pro Gly Arg Asp Leu
625                 630                 635                 640 
Leu Leu Gln Thr Arg Leu Val Asn His Val Ser Ser Met Arg Pro Asn
                645                 650                 655     
Ile Phe Leu Gly Val Ser Glu Gly Ser Ala Gln Tyr Lys Lys Trp Tyr
            660                 665                 670         
Tyr Glu Leu Met Val Asp His Thr Glu Pro Phe Val Thr Ala Glu Ala
        675                 680                 685             
Thr His Leu Arg Val Gly Trp Ala Ser Thr Glu Gly Tyr Ser Pro Tyr
    690                 695                 700                 
Pro Gly Gly Gly Glu Glu Trp Gly Gly Asn Gly Val Gly Asp Asp Leu
705                 710                 715                 720 
Phe Ser Tyr Gly Phe Asp Gly Leu His Leu Trp Ser Gly Cys Ile Ala
                725                 730                 735     
Arg Thr Val Ser Ser Pro Asn Gln His Leu Leu Arg Thr Asp Asp Val
            740                 745                 750         
Ile Ser Cys Cys Leu Asp Leu Ser Ala Pro Ser Ile Ser Phe Arg Ile
        755                 760                 765             
Asn Gly Gln Pro Val Gln Gly Met Phe Glu Asn Phe Asn Ile Asp Gly
    770                 775                 780                 
Leu Phe Phe Pro Val Val Ser Phe Ser Ala Gly Ile Lys Val Arg Phe
785                 790                 795                 800 
Leu Leu Gly Gly Arg His Gly Glu Phe Lys Phe Leu Pro Pro Pro Gly
                805                 810                 815     
Tyr Ala Pro Cys Tyr Glu Ala Val Leu Pro Lys Glu Lys Leu Lys Val
            820                 825                 830         
Glu His Ser Arg Glu Tyr Lys Gln Glu Arg Thr Tyr Thr Arg Asp Leu
        835                 840                 845             
Leu Gly Pro Thr Val Ser Leu Thr Gln Ala Ala Phe Thr Pro Ile Pro
    850                 855                 860                 
Val Asp Thr Ser Gln Ile Val Leu Pro Pro His Leu Glu Arg Ile Arg
865                 870                 875                 880 
Glu Lys Leu Ala Glu Asn Ile His Glu Leu Trp Val Met Asn Lys Ile
                885                 890                 895     
Glu Leu Gly Trp Gln Tyr Gly Pro Val Arg Asp Asp Asn Lys Arg Gln
            900                 905                 910         
His Pro Cys Leu Val Glu Phe Ser Lys Leu Pro Glu Gln Glu Arg Asn
        915                 920                 925             
Tyr Asn Leu Gln Met Ser Leu Glu Thr Leu Lys Thr Leu Leu Ala Leu
    930                 935                 940                 
Gly Cys His Val Gly Ile Ser Asp Glu His Ala Glu Asp Lys Val Lys
945                 950                 955                 960 
Lys Met Lys Leu Pro Lys Asn Tyr Gln Leu Thr Ser Gly Tyr Lys Pro
                965                 970                 975     
Ala Pro Met Asp Leu Ser Phe Ile Lys Leu Thr Pro Ser Gln Glu Ala
            980                 985                 990         
Met Val Asp Lys Leu Ala Glu Asn Ala His Asn Val Trp Ala Arg Asp
        995                 1000                1005            
Arg Ile Arg Gln Gly Trp Thr Tyr Gly Ile Gln Gln Asp Val Lys Asn
    1010                1015                1020                
Arg Arg Asn Pro Arg Leu Val Pro Tyr Thr Leu Leu Asp Asp Arg Thr
1025                1030                1035                1040
Lys Lys Ser Asn Lys Asp Ser Leu Arg Glu Ala Val Arg Thr Leu Leu
                1045                1050                1055    
Gly Tyr Gly Tyr Asn Leu Glu Ala Pro Asp Gln Asp His Ala Ala Arg
            1060                1065                1070        
Ala Glu Val Cys Ser Gly Thr Gly Glu Arg Phe Arg Ile Phe Arg Ala
        1075                1080                1085            
Glu Lys Thr Tyr Ala Val Lys Ala Gly Arg Trp Tyr Phe Glu Phe Glu
    1090                1095                1100                
Thr Val Thr Ala Gly Asp Met Arg Val Gly Trp Ser Arg Pro Gly Cys
1105                1110                1115                1120
Gln Pro Asp Gln Glu Leu Gly Ser Asp Glu Arg Ala Phe Ala Phe Asp
                1125                1130                1135    
Gly Phe Lys Ala Gln Arg Trp His Gln Gly Asn Glu His Tyr Gly Arg
            1140                1145                1150        
Ser Trp Gln Ala Gly Asp Val Val Gly Cys Met Val Asp Met Asn Glu
        1155                1160                1165            
His Thr Met Met Phe Thr Leu Asn Gly Glu Ile Leu Leu Asp Asp Ser
    1170                1175                1180                
Gly Ser Glu Leu Ala Phe Lys Asp Phe Asp Val Gly Asp Gly Phe Ile
1185                1190                1195                1200
Pro Val Cys Ser Leu Gly Val Ala Gln Val Gly Arg Met Asn Phe Gly
                1205                1210                1215    
Lys Asp Val Ser Thr Leu Lys Tyr Phe Thr Ile Cys Gly Leu Gln Glu
            1220                1225                1230        
Gly Tyr Glu Pro Phe Ala Val Asn Thr Asn Arg Asp Ile Thr Met Trp
        1235                1240                1245            
Leu Ser Lys Arg Leu Pro Gln Phe Leu Gln Val Pro Ser Asn His Glu
    1250                1255                1260                
His Ile Glu Val Thr Arg Ile Asp Gly Thr Ile Asp Ser Ser Pro Cys
1265                1270                1275                1280
Leu Lys Val Thr Gln Lys Ser Phe Gly Ser Gln Asn Ser Asn Thr Asp
                1285                1290                1295    
Ile Met Phe Tyr Arg Leu Ser Met Pro Ile Glu Cys Ala Glu Val Phe
            1300                1305                1310        
Ser Lys Thr Val Ala Gly Gly Leu Pro Gly Ala Gly Leu Phe Gly Pro
        1315                1320                1325            
Lys Asn Asp Leu Glu Asp Tyr Asp Ala Asp Ser Asp Phe Glu Val Leu
    1330                1335                1340                
Met Lys Thr Ala His Gly His Leu Val Pro Asp Arg Val Asp Lys Asp
1345                1350                1355                1360
Lys Glu Ala Thr Lys Pro Glu Phe Asn Asn His Lys Asp Tyr Ala Gln
                1365                1370                1375    
Glu Lys Pro Ser Arg Leu Lys Gln Arg Phe Leu Leu Arg Arg Thr Lys
            1380                1385                1390        
Pro Asp Tyr Ser Thr Ser His Ser Ala Arg Leu Thr Glu Asp Val Leu
        1395                1400                1405            
Ala Asp Asp Arg Asp Asp Tyr Asp Phe Leu Met Gln Thr Ser Thr Tyr
    1410                1415                1420                
Tyr Tyr Ser Val Arg Ile Phe Pro Gly Gln Glu Pro Ala Asn Val Trp
1425                1430                1435                1440
Val Gly Trp Ile Thr Ser Asp Phe His Gln Tyr Asp Thr Gly Phe Asp
                1445                1450                1455    
Leu Asp Arg Val Arg Thr Val Thr Val Thr Leu Gly Asp Glu Lys Gly
            1460                1465                1470        
Lys Val His Glu Ser Ile Lys Arg Ser Asn Cys Tyr Met Val Cys Ala
        1475                1480                1485            
Gly Glu Ser Met Ser Pro Gly Gln Gly Arg Asn Asn Asn Gly Leu Glu
    1490                1495                1500                
Ile Gly Cys Val Val Asp Ala Ala Ser Gly Leu Leu Thr Phe Ile Ala
1505                1510                1515                1520
Asn Gly Lys Glu Leu Ser Thr Tyr Tyr Gln Val Glu Pro Ser Thr Lys
                1525                1530                1535    
Leu Phe Pro Ala Val Phe Ala Gln Ala Thr Ser Pro Asn Val Phe Gln
            1540                1545                1550        
Phe Glu Leu Gly Arg Ile Lys Asn Val Met Pro Leu Ser Ala Gly Leu
        1555                1560                1565            
Phe Lys Ser Glu His Lys Asn Pro Val Pro Gln Cys Pro Pro Arg Leu
    1570                1575                1580                
His Val Gln Phe Leu Ser His Val Leu Trp Ser Arg Met Pro Asn Gln
1585                1590                1595                1600
Phe Leu Lys Val Asp Val Ser Arg Ile Ser Glu Arg Gln Gly Trp Leu
                1605                1610                1615    
Val Gln Cys Leu Asp Pro Leu Gln Phe Met Ser Leu His Ile Pro Glu
            1620                1625                1630        
Glu Asn Arg Ser Val Asp Ile Leu Glu Leu Thr Glu Gln Glu Glu Leu
        1635                1640                1645            
Leu Lys Phe His Tyr His Thr Leu Arg Leu Tyr Ser Ala Val Cys Ala
    1650                1655                1660                
Leu Gly Asn His Arg Val Ala His Ala Leu Cys Ser His Val Asp Glu
1665                1670                1675                1680
Pro Gln Leu Leu Tyr Ala Ile Glu Asn Lys Tyr Met Pro Gly Leu Leu
                1685                1690                1695    
Arg Ala Gly Tyr Tyr Asp Leu Leu Ile Asp Ile His Leu Ser Ser Tyr
            1700                1705                1710        
Ala Thr Ala Arg Leu Met Met Asn Asn Glu Tyr Ile Val Pro Met Thr
        1715                1720                1725            
Glu Glu Thr Lys Ser Ile Thr Leu Phe Pro Asp Glu Asn Lys Lys His
    1730                1735                1740                
Gly Leu Pro Gly Ile Gly Leu Ser Thr Ser Leu Arg Pro Arg Met Gln
1745                1750                1755                1760
Phe Ser Ser Pro Ser Phe Val Ser Ile Ser Asn Glu Cys Tyr Gln Tyr
                1765                1770                1775    
Ser Pro Glu Phe Pro Leu Asp Ile Leu Lys Ser Lys Thr Ile Gln Met
            1780                1785                1790        
Leu Thr Glu Ala Val Lys Glu Gly Ser Leu His Ala Arg Asp Pro Val
        1795                1800                1805            
Gly Gly Thr Thr Glu Phe Leu Phe Val Pro Leu Ile Lys Leu Phe Tyr
    1810                1815                1820                
Thr Leu Leu Ile Met Gly Ile Phe His Asn Glu Asp Leu Lys His Ile
1825                1830                1835                1840
Leu Gln Leu Ile Glu Pro Ser Val Phe Lys Glu Ala Ala Thr Pro Glu
                1845                1850                1855    
Glu Glu Ser Asp Thr Leu Glu Lys Glu Leu Ser Val Asp Asp Ala Lys
            1860                1865                1870        
Leu Gln Gly Ala Gly Glu Glu Glu Ala Lys Gly Gly Lys Arg Pro Lys
        1875                1880                1885            
Glu Gly Leu Leu Gln Met Lys Leu Pro Glu Pro Val Lys Leu Gln Met
    1890                1895                1900                
Cys Leu Leu Leu Gln Tyr Leu Cys Asp Cys Gln Val Arg His Arg Ile
1905                1910                1915                1920
Glu Ala Ile Val Ala Phe Ser Asp Asp Phe Val Ala Lys Leu Gln Asp
                1925                1930                1935    
Asn Gln Arg Phe Arg Tyr Asn Glu Val Met Gln Ala Leu Asn Met Ser
            1940                1945                1950        
Ala Ala Leu Thr Ala Arg Lys Thr Lys Glu Phe Arg Ser Pro Pro Gln
        1955                1960                1965            
Glu Gln Ile Asn Met Leu Leu Asn Phe Lys Asp Asp Lys Ser Glu Cys
    1970                1975                1980                
Pro Cys Pro Glu Glu Ile Arg Asp Gln Leu Leu Asp Phe His Glu Asp
1985                1990                1995                2000
Leu Met Thr His Cys Gly Ile Glu Leu Asp Glu Asp Gly Ser Leu Asp
                2005                2010                2015    
Gly Asn Ser Asp Leu Thr Ile Arg Gly Arg Leu Leu Ser Leu Val Glu
            2020                2025                2030        
Lys Val Thr Tyr Leu Lys Lys Lys Gln Ala Glu Lys Pro Val Glu Ser
        2035                2040                2045            
Asp Ser Lys Lys Ser Ser Thr Leu Gln Gln Leu Ile Ser Glu Thr Met
    2050                2055                2060                
Val Arg Trp Ala Gln Glu Ser Val Ile Glu Asp Pro Glu Leu Val Arg
2065                2070                2075                2080
Ala Met Phe Val Leu Leu His Arg Gln Tyr Asp Gly Ile Gly Gly Leu
                2085                2090                2095    
Val Arg Ala Leu Pro Lys Thr Tyr Thr Ile Asn Gly Val Ser Val Glu
            2100                2105                2110        
Asp Thr Ile Asn Leu Leu Ala Ser Leu Gly Gln Ile Arg Ser Leu Leu
        2115                2120                2125            
Ser Val Arg Met Gly Lys Glu Glu Glu Lys Leu Met Ile Arg Gly Leu
    2130                2135                2140                
Gly Asp Ile Met Asn Asn Lys Val Phe Tyr Gln His Pro Asn Leu Met
2145                2150                2155                2160
Arg Ala Leu Gly Met His Glu Thr Val Met Glu Val Met Val Asn Val
                2165                2170                2175    
Leu Gly Gly Gly Glu Ser Lys Glu Ile Thr Phe Pro Lys Met Val Ala
            2180                2185                2190        
Asn Cys Cys Arg Phe Leu Cys Tyr Phe Cys Arg Ile Ser Arg Gln Asn
        2195                2200                2205            
Gln Lys Ala Met Phe Asp His Leu Ser Tyr Leu Leu Glu Asn Ser Ser
    2210                2215                2220                
Val Gly Leu Ala Ser Pro Ala Met Arg Gly Ser Thr Pro Leu Asp Val
2225                2230                2235                2240
Ala Ala Ala Ser Val Met Asp Asn Asn Glu Leu Ala Leu Ala Leu Arg
                2245                2250                2255    
Glu Pro Asp Leu Glu Lys Val Val Arg Tyr Leu Ala Gly Cys Gly Leu
            2260                2265                2270        
Gln Ser Cys Gln Met Leu Val Ser Lys Gly Tyr Pro Asp Ile Gly Trp
        2275                2280                2285            
Asn Pro Val Glu Gly Glu Arg Tyr Leu Asp Phe Leu Arg Phe Ala Val
    2290                2295                2300                
Phe Cys Asn Gly Glu Ser Val Glu Glu Asn Ala Asn Val Val Val Arg
2305                2310                2315                2320
Leu Leu Ile Arg Arg Pro Glu Cys Phe Gly Pro Ala Leu Arg Gly Glu
                2325                2330                2335    
Gly Gly Asn Gly Leu Leu Ala Ala Met Glu Glu Ala Ile Lys Ile Ala
            2340                2345                2350        
Glu Asp Pro Ser Arg Asp Gly Pro Ser Pro Asn Ser Gly Ser Ser Lys
        2355                2360                2365            
Thr Leu Asp Thr Glu Glu Glu Glu Asp Asp Thr Ile His Met Gly Asn
    2370                2375                2380                
Ala Ile Met Thr Phe Tyr Ser Ala Leu Ile Asp Leu Leu Gly Arg Cys
2385                2390                2395                2400
Ala Pro Glu Met His Leu Ile His Ala Gly Lys Gly Glu Ala Ile Arg
                2405                2410                2415    
Ile Arg Ser Ile Leu Arg Ser Leu Ile Pro Leu Gly Asp Leu Val Gly
            2420                2425                2430        
Val Ile Ser Ile Ala Phe Gln Met Pro Thr Ile Ala Lys Asp Gly Asn
        2435                2440                2445            
Val Val Glu Pro Asp Met Ser Ala Gly Phe Cys Pro Asp His Lys Ala
    2450                2455                2460                
Ala Met Val Leu Phe Leu Asp Arg Val Tyr Gly Ile Glu Val Gln Asp
2465                2470                2475                2480
Phe Leu Leu His Leu Leu Glu Val Gly Phe Leu Pro Asp Leu Arg Ala
                2485                2490                2495    
Ala Ala Ser Leu Asp Thr Ala Ala Leu Ser Ala Thr Asp Met Ala Leu
            2500                2505                2510        
Ala Leu Asn Arg Tyr Leu Cys Thr Ala Val Leu Pro Leu Leu Thr Arg
        2515                2520                2525            
Cys Ala Pro Leu Phe Ala Gly Thr Glu His His Ala Ser Leu Ile Asp
    2530                2535                2540                
Ser Leu Leu His Thr Val Tyr Arg Leu Ser Lys Gly Cys Ser Leu Thr
2545                2550                2555                2560
Lys Ala Gln Arg Asp Ser Ile Glu Val Cys Leu Leu Ser Ile Cys Gly
                2565                2570                2575    
Gln Leu Arg Pro Ser Met Met Gln His Leu Leu Arg Arg Leu Val Phe
            2580                2585                2590        
Asp Val Pro Leu Leu Asn Glu His Ala Lys Met Pro Leu Lys Leu Leu
        2595                2600                2605            
Thr Asn His Tyr Glu Arg Cys Trp Lys Tyr Tyr Cys Leu Pro Gly Gly
    2610                2615                2620                
Trp Gly Asn Phe Gly Ala Ala Ser Glu Glu Glu Leu His Leu Ser Arg
2625                2630                2635                2640
Lys Leu Phe Trp Gly Ile Phe Asp Ala Leu Ser Gln Lys Lys Tyr Glu
                2645                2650                2655    
Gln Glu Leu Phe Lys Leu Ala Leu Pro Cys Leu Ser Ala Val Ala Gly
            2660                2665                2670        
Ala Leu Pro Pro Asp Tyr Met Glu Ser Asn Tyr Val Ser Met Met Glu
        2675                2680                2685            
Lys Gln Ser Ser Met Asp Ser Glu Gly Asn Phe Asn Pro Gln Pro Val
    2690                2695                2700                
Asp Thr Ser Asn Ile Thr Ile Pro Glu Lys Leu Glu Tyr Phe Ile Asn
2705                2710                2715                2720
Lys Tyr Ala Glu His Ser His Asp Lys Trp Ser Met Asp Lys Leu Ala
                2725                2730                2735    
Asn Gly Trp Ile Tyr Gly Glu Ile Tyr Ser Asp Ser Ser Lys Val Gln
            2740                2745                2750        
Pro Leu Met Lys Pro Tyr Lys Leu Leu Ser Glu Lys Glu Lys Glu Ile
        2755                2760                2765            
Tyr Arg Trp Pro Ile Lys Glu Ser Leu Lys Thr Met Leu Ala Trp Gly
    2770                2775                2780                
Trp Arg Ile Glu Arg Thr Arg Glu Gly Asp Ser Met Ala Leu Tyr Asn
2785                2790                2795                2800
Arg Thr Arg Arg Ile Ser Gln Thr Ser Gln Val Ser Val Asp Ala Ala
                2805                2810                2815    
His Gly Tyr Ser Pro Arg Ala Ile Asp Met Ser Asn Val Thr Leu Ser
            2820                2825                2830        
Arg Asp Leu His Ala Met Ala Glu Met Met Ala Glu Asn Tyr His Asn
        2835                2840                2845            
Ile Trp Ala Lys Lys Lys Lys Met Glu Leu Glu Ser Lys Gly Gly Gly
    2850                2855                2860                
Asn His Pro Leu Leu Val Pro Tyr Asp Thr Leu Thr Ala Lys Glu Lys
2865                2870                2875                2880
Ala Lys Asp Arg Glu Lys Ala Gln Asp Ile Leu Lys Phe Leu Gln Ile
                2885                2890                2895    
Asn Gly Tyr Ala Val Ser Arg Gly Phe Lys Asp Leu Glu Leu Asp Thr
            2900                2905                2910        
Pro Ser Ile Glu Lys Arg Phe Ala Tyr Ser Phe Leu Gln Gln Leu Ile
        2915                2920                2925            
Arg Tyr Val Asp Glu Ala His Gln Tyr Ile Leu Glu Phe Asp Gly Gly
    2930                2935                2940                
Ser Arg Gly Lys Gly Glu His Phe Pro Tyr Glu Gln Glu Ile Lys Phe
2945                2950                2955                2960
Phe Ala Lys Val Val Leu Pro Leu Ile Asp Gln Tyr Phe Lys Asn His
                2965                2970                2975    
Arg Leu Tyr Phe Leu Ser Ala Ala Ser Arg Pro Leu Cys Ser Gly Gly
            2980                2985                2990        
His Ala Ser Asn Lys Glu Lys Glu Met Val Thr Ser Leu Phe Cys Lys
        2995                3000                3005            
Leu Gly Val Leu Val Arg His Arg Ile Ser Leu Phe Gly Asn Asp Ala
    3010                3015                3020                
Thr Ser Ile Val Asn Cys Leu His Ile Leu Gly Gln Thr Leu Asp Ala
3025                3030                3035                3040
Arg Thr Val Met Lys Thr Gly Leu Glu Ser Val Lys Ser Ala Leu Arg
                3045                3050                3055    
Ala Phe Leu Asp Asn Ala Ala Glu Asp Leu Glu Lys Thr Met Glu Asn
            3060                3065                3070        
Leu Lys Gln Gly Gln Phe Thr His Thr Arg Asn Gln Pro Lys Gly Val
        3075                3080                3085            
Thr Gln Ile Ile Asn Tyr Thr Thr Val Ala Leu Leu Pro Met Leu Ser
    3090                3095                3100                
Ser Leu Phe Glu His Ile Gly Gln His Gln Phe Gly Glu Asp Leu Ile
3105                3110                3115                3120
Leu Glu Asp Val Gln Val Ser Cys Tyr Arg Ile Leu Thr Ser Leu Tyr
                3125                3130                3135    
Ala Leu Gly Thr Ser Lys Ser Ile Tyr Val Glu Arg Gln Arg Ser Ala
            3140                3145                3150        
Leu Gly Glu Cys Leu Ala Ala Phe Ala Gly Ala Phe Pro Val Ala Phe
        3155                3160                3165            
Leu Glu Thr His Leu Asp Lys His Asn Ile Tyr Ser Ile Tyr Asn Thr
    3170                3175                3180                
Lys Ser Ser Arg Glu Arg Ala Ala Leu Ser Leu Pro Thr Asn Val Glu
3185                3190                3195                3200
Asp Val Cys Pro Asn Ile Pro Ser Leu Glu Lys Leu Met Glu Glu Ile
                3205                3210                3215    
Val Glu Leu Ala Glu Ser Gly Ile Arg Tyr Thr Gln Met Pro His Val
            3220                3225                3230        
Met Glu Val Ile Leu Pro Met Leu Cys Ser Tyr Met Ser Arg Trp Trp
        3235                3240                3245            
Glu His Gly Pro Glu Asn Asn Pro Glu Arg Ala Glu Met Cys Cys Thr
    3250                3255                3260                
Ala Leu Asn Ser Glu His Met Asn Thr Leu Leu Gly Asn Ile Leu Lys
3265                3270                3275                3280
Ile Ile Tyr Asn Asn Leu Gly Ile Asp Glu Gly Ala Trp Met Lys Arg
                3285                3290                3295    
Leu Ala Val Phe Ser Gln Pro Ile Ile Asn Lys Val Lys Pro Gln Leu
            3300                3305                3310        
Leu Lys Thr His Phe Leu Pro Leu Met Glu Lys Leu Lys Lys Lys Ala
        3315                3320                3325            
Ala Thr Val Val Ser Glu Glu Asp His Leu Lys Ala Glu Ala Arg Gly
    3330                3335                3340                
Asp Met Ser Glu Ala Glu Leu Leu Ile Leu Asp Glu Phe Thr Thr Leu
3345                3350                3355                3360
Ala Arg Asp Leu Tyr Ala Phe Tyr Pro Leu Leu Ile Arg Phe Val Asp
                3365                3370                3375    
Tyr Asn Arg Ala Lys Trp Leu Lys Glu Pro Asn Pro Glu Ala Glu Glu
            3380                3385                3390        
Leu Phe Arg Met Val Ala Glu Val Phe Ile Tyr Trp Ser Lys Ser His
        3395                3400                3405            
Asn Phe Lys Arg Glu Glu Gln Asn Phe Val Val Gln Asn Glu Ile Asn
    3410                3415                3420                
Asn Met Ser Phe Leu Ile Thr Asp Thr Lys Ser Lys Met Ser Lys Ala
3425                3430                3435                3440
Ala Val Ser Asp Gln Glu Arg Lys Lys Met Lys Arg Lys Gly Asp Arg
                3445                3450                3455    
Tyr Ser Met Gln Thr Ser Leu Ile Val Ala Ala Leu Lys Arg Leu Leu
            3460                3465                3470        
Pro Ile Gly Leu Asn Ile Cys Ala Pro Gly Asp Gln Glu Leu Ile Ala
        3475                3480                3485            
Leu Ala Lys Asn Arg Phe Ser Leu Lys Asp Thr Glu Asp Glu Val Arg
    3490                3495                3500                
Asp Ile Ile Arg Ser Asn Ile His Leu Gln Gly Lys Leu Glu Asp Pro
3505                3510                3515                3520
Ala Ile Arg Trp Gln Met Ala Leu Tyr Lys Asp Leu Pro Asn Arg Thr
                3525                3530                3535    
Asp Asp Thr Ser Asp Pro Glu Lys Thr Val Glu Arg Val Leu Asp Ile
            3540                3545                3550        
Ala Asn Val Leu Phe His Leu Glu Gln Lys Ser Lys Arg Val Gly Arg
        3555                3560                3565            
Arg His Tyr Cys Leu Val Glu His Pro Gln Arg Ser Lys Lys Ala Val
    3570                3575                3580                
Trp His Lys Leu Leu Ser Lys Gln Arg Lys Arg Ala Val Val Ala Cys
3585                3590                3595                3600
Phe Arg Met Ala Pro Leu Tyr Asn Leu Pro Arg His Arg Ala Val Asn
                3605                3610                3615    
Leu Phe Leu Gln Gly Tyr Glu Lys Ser Trp Ile Glu Thr Glu Glu His
            3620                3625                3630        
Tyr Phe Glu Asp Lys Leu Ile Glu Asp Leu Ala Glu Thr Trp Gly
        3635                3640                3645        


<210> 2437
<211> 467
<212> PRT
<213> Homo sapiens

<400> 2437
Met Ser Gln Gly Val Arg Arg Ala Gly Ala Gly Gln Gly Val Ala Ala
 1               5                  10                  15      
Ala Val Gln Leu Leu Val Thr Leu Ser Phe Leu Arg Ser Val Val Glu
            20                  25                  30          
Ala Gln Val Thr Gly Val Leu Asp Asp Cys Leu Cys Asp Ile Asp Ser
        35                  40                  45              
Ile Asp Asn Phe Asn Thr Tyr Lys Ile Phe Pro Lys Ile Lys Lys Leu
    50                  55                  60                  
Gln Glu Arg Asp Tyr Phe Arg Tyr Tyr Lys Val Asn Leu Lys Arg Pro
65                  70                  75                  80  
Cys Pro Phe Trp Ala Glu Asp Gly His Cys Ser Ile Lys Asp Cys His
                85                  90                  95      
Val Glu Pro Cys Pro Glu Ser Lys Ile Pro Val Gly Ile Lys Ala Gly
            100                 105                 110         
His Ser Asn Lys Tyr Leu Lys Met Ala Asn Asn Thr Lys Glu Leu Glu
        115                 120                 125             
Asp Cys Glu Gln Ala Asn Lys Leu Gly Ala Ile Asn Ser Thr Leu Ser
    130                 135                 140                 
Asn Gln Ser Lys Glu Ala Phe Ile Asp Trp Ala Arg Tyr Asp Asp Ser
145                 150                 155                 160 
Arg Asp His Phe Cys Glu Leu Asp Asp Glu Arg Ser Pro Ala Ala Gln
                165                 170                 175     
Tyr Val Asp Leu Leu Leu Asn Pro Glu Arg Tyr Thr Gly Tyr Lys Gly
            180                 185                 190         
Thr Ser Ala Trp Arg Val Trp Asn Ser Ile Tyr Glu Glu Asn Cys Phe
        195                 200                 205             
Lys Pro Arg Ser Val Tyr Arg Pro Leu Asn Pro Leu Ala Pro Ser Arg
    210                 215                 220                 
Gly Glu Asp Asp Gly Glu Ser Phe Tyr Thr Trp Leu Glu Gly Leu Cys
225                 230                 235                 240 
Leu Glu Lys Arg Val Phe Tyr Lys Leu Ile Ser Gly Leu His Ala Ser
                245                 250                 255     
Ile Asn Leu His Leu Cys Ala Asn Tyr Leu Leu Glu Glu Thr Trp Gly
            260                 265                 270         
Lys Pro Ser Trp Gly Pro Asn Ile Lys Glu Phe Lys His Arg Phe Asp
        275                 280                 285             
Pro Val Glu Thr Lys Gly Glu Gly Pro Arg Arg Leu Lys Asn Leu Tyr
    290                 295                 300                 
Phe Leu Tyr Leu Ile Glu Leu Arg Ala Leu Ser Lys Val Ala Pro Tyr
305                 310                 315                 320 
Phe Glu Arg Ser Ile Val Asp Leu Tyr Thr Gly Asn Ala Glu Glu Asp
                325                 330                 335     
Ala Asp Thr Lys Thr Leu Leu Leu Asn Ile Phe Gln Asp Thr Lys Ser
            340                 345                 350         
Phe Pro Met His Phe Asp Glu Lys Ser Met Phe Ala Gly Asp Lys Lys
        355                 360                 365             
Gly Ala Lys Ser Leu Lys Glu Glu Phe Arg Leu His Phe Lys Asn Ile
    370                 375                 380                 
Ser Arg Ile Met Asp Cys Val Gly Cys Asp Lys Cys Arg Leu Trp Gly
385                 390                 395                 400 
Lys Leu Gln Thr Gln Gly Leu Gly Thr Ala Leu Lys Ile Leu Phe Ser
                405                 410                 415     
Glu Lys Glu Ile Gln Lys Leu Pro Glu Asn Ser Pro Ser Lys Gly Phe
            420                 425                 430         
Gln Leu Thr Arg Gln Glu Ile Val Ala Leu Leu Asn Ala Phe Gly Arg
        435                 440                 445             
Leu Ser Thr Ser Ile Arg Asp Leu Gln Asn Phe Lys Val Leu Leu Gln
    450                 455                 460                 
His Ser Arg
465         


<210> 2438
<211> 1121
<212> PRT
<213> Homo sapiens

<400> 2438
Met His Ser Asp Glu Met Ile Tyr Asp Asp Val Glu Asn Gly Asp Glu
 1               5                  10                  15      
Gly Gly Asn Ser Ser Leu Glu Tyr Gly Trp Ser Ser Ser Glu Phe Glu
            20                  25                  30          
Ser Tyr Glu Glu Gln Ser Asp Ser Glu Cys Lys Asn Gly Ile Pro Arg
        35                  40                  45              
Ser Phe Leu Arg Ser Asn His Lys Lys Gln Leu Ser His Asp Leu Thr
    50                  55                  60                  
Arg Leu Lys Glu His Tyr Glu Lys Lys Met Arg Asp Leu Met Ala Ser
65                  70                  75                  80  
Thr Val Gly Val Val Glu Ile Gln Gln Leu Arg Gln Lys His Glu Leu
                85                  90                  95      
Lys Met Gln Lys Leu Val Lys Ala Ala Lys Asp Gly Thr Lys Asp Gly
            100                 105                 110         
Leu Glu Arg Thr Arg Ala Ala Val Lys Arg Gly Arg Ser Phe Ile Arg
        115                 120                 125             
Thr Lys Ser Leu Ile Ala Gln Asp His Arg Ser Ser Leu Glu Glu Glu
    130                 135                 140                 
Gln Asn Leu Phe Ile Asp Val Asp Cys Lys His Pro Glu Ala Ile Leu
145                 150                 155                 160 
Thr Pro Met Pro Glu Gly Leu Ser Gln Gln Gln Val Val Arg Arg Tyr
                165                 170                 175     
Ile Leu Gly Ser Val Val Asp Ser Glu Lys Asn Tyr Val Asp Ala Leu
            180                 185                 190         
Lys Arg Ile Leu Glu Gln Tyr Glu Lys Pro Leu Ser Glu Met Glu Pro
        195                 200                 205             
Lys Val Leu Ser Glu Arg Lys Leu Lys Thr Val Phe Tyr Arg Val Lys
    210                 215                 220                 
Glu Ile Leu Gln Cys His Ser Leu Phe Gln Ile Ala Leu Ala Ser Arg
225                 230                 235                 240 
Val Ser Glu Trp Asp Ser Val Glu Met Ile Gly Asp Val Phe Val Ala
                245                 250                 255     
Ser Phe Ser Lys Ser Met Val Leu Asp Ala Tyr Ser Glu Tyr Val Asn
            260                 265                 270         
Asn Phe Ser Thr Ala Val Ala Val Leu Lys Lys Thr Cys Ala Thr Lys
        275                 280                 285             
Pro Ala Phe Leu Glu Phe Leu Lys Gln Glu Gln Glu Ala Ser Pro Asp
    290                 295                 300                 
Arg Thr Thr Leu Tyr Ser Leu Met Met Lys Pro Ile Gln Arg Phe Pro
305                 310                 315                 320 
Gln Phe Ile Leu Leu Leu Gln Asp Met Leu Lys Asn Thr Ser Lys Gly
                325                 330                 335     
His Pro Asp Arg Leu Pro Leu Gln Met Ala Leu Thr Glu Leu Glu Thr
            340                 345                 350         
Leu Ala Glu Lys Leu Asn Glu Arg Lys Arg Asp Ala Asp Gln Arg Cys
        355                 360                 365             
Glu Val Lys Gln Ile Ala Lys Ala Ile Asn Glu Arg Tyr Leu Asn Lys
    370                 375                 380                 
Leu Leu Ser Ser Gly Ser Arg Tyr Leu Ile Arg Ser Asp Asp Met Ile
385                 390                 395                 400 
Glu Thr Val Tyr Asn Asp Arg Gly Glu Ile Val Lys Thr Lys Glu Arg
                405                 410                 415     
Arg Val Phe Met Leu Asn Asp Val Leu Met Cys Ala Thr Val Ser Ser
            420                 425                 430         
Arg Pro Ser His Asp Ser Arg Val Met Ser Ser Gln Arg Tyr Leu Leu
        435                 440                 445             
Lys Trp Ser Val Pro Leu Gly His Val Asp Ala Ile Glu Tyr Gly Ser
    450                 455                 460                 
Ser Ala Gly Thr Gly Glu His Ser Arg His Leu Ala Val His Pro Pro
465                 470                 475                 480 
Glu Ser Leu Ala Val Val Ala Asn Ala Lys Pro Asn Lys Val Tyr Met
                485                 490                 495     
Gly Pro Gly Gln Leu Tyr Gln Asp Leu Gln Asn Leu Leu His Asp Leu
            500                 505                 510         
Asn Val Ile Gly Gln Ile Thr Gln Leu Ile Gly Asn Leu Lys Gly Asn
        515                 520                 525             
Tyr Gln Asn Leu Asn Gln Ser Val Ala His Asp Trp Thr Ser Gly Leu
    530                 535                 540                 
Gln Arg Leu Ile Leu Lys Lys Glu Asp Glu Ile Arg Ala Ala Asp Cys
545                 550                 555                 560 
Cys Arg Ile Gln Leu Gln Leu Pro Gly Lys Gln Asp Lys Ser Gly Arg
                565                 570                 575     
Pro Thr Phe Phe Thr Ala Val Phe Asn Thr Phe Thr Pro Ala Ile Lys
            580                 585                 590         
Glu Ser Trp Val Asn Ser Leu Gln Met Ala Lys Leu Ala Leu Glu Glu
        595                 600                 605             
Glu Asn His Met Gly Trp Phe Cys Val Glu Asp Asp Gly Asn His Ile
    610                 615                 620                 
Lys Lys Glu Lys His Pro Leu Leu Val Gly His Met Pro Val Met Val
625                 630                 635                 640 
Ala Lys Gln Gln Glu Phe Lys Ile Glu Cys Ala Ala Tyr Asn Pro Glu
                645                 650                 655     
Pro Tyr Leu Asn Asn Glu Ser Gln Pro Asp Ser Phe Ser Thr Ala His
            660                 665                 670         
Gly Phe Leu Trp Ile Gly Ser Cys Thr His Gln Met Gly Gln Ile Ala
        675                 680                 685             
Ile Val Ser Phe Gln Asn Ser Thr Pro Lys Val Ile Glu Cys Phe Asn
    690                 695                 700                 
Val Glu Ser Arg Ile Leu Cys Met Leu Tyr Val Pro Val Glu Glu Lys
705                 710                 715                 720 
Arg Arg Glu Pro Gly Ala Pro Pro Asp Pro Glu Thr Pro Ala Val Arg
                725                 730                 735     
Ala Ser Asp Val Pro Thr Ile Cys Val Gly Met Glu Glu Gly Ser Ile
            740                 745                 750         
Ser Ile Tyr Lys Ser Ser Gln Gly Ser Lys Lys Val Arg Leu Gln His
        755                 760                 765             
Phe Phe Thr Pro Glu Lys Ser Thr Val Met Ser Leu Ala Cys Thr Ser
    770                 775                 780                 
Gln Ser Leu Tyr Ala Gly Leu Val Asn Gly Ala Val Ala Ser Tyr Ala
785                 790                 795                 800 
Arg Ala Pro Asp Gly Ser Trp Asp Ser Glu Pro Gln Lys Val Ile Lys
                805                 810                 815     
Leu Gly Val Leu Pro Val Arg Ser Leu Leu Met Met Glu Asp Thr Leu
            820                 825                 830         
Trp Ala Ala Ser Gly Gly Gln Val Phe Ile Ile Ser Val Glu Thr His
        835                 840                 845             
Ala Val Glu Gly Gln Leu Glu Ala His Gln Glu Glu Gly Met Val Ile
    850                 855                 860                 
Ser His Met Ala Val Ser Gly Val Gly Ile Trp Ile Ala Phe Thr Ser
865                 870                 875                 880 
Gly Ser Thr Leu Arg Leu Phe His Thr Glu Thr Leu Lys His Leu Gln
                885                 890                 895     
Asp Ile Asn Ile Ala Thr Pro Val His Asn Met Leu Pro Gly His Gln
            900                 905                 910         
Arg Leu Ser Val Thr Ser Leu Leu Val Cys His Gly Leu Leu Met Val
        915                 920                 925             
Gly Thr Ser Leu Gly Val Leu Val Ala Leu Pro Val Pro Arg Leu Gln
    930                 935                 940                 
Gly Ile Pro Lys Val Thr Gly Arg Gly Met Val Ser Tyr His Ala His
945                 950                 955                 960 
Asn Ser Pro Val Lys Phe Ile Val Leu Ala Thr Ala Leu His Glu Lys
                965                 970                 975     
Asp Lys Asp Lys Ser Arg Asp Ser Leu Ala Pro Gly Pro Glu Pro Gln
            980                 985                 990         
Asp Glu Asp Gln Lys Asp Ala Leu Pro Ser Gly Gly Ala Gly Ser Ser
        995                 1000                1005            
Leu Ser Gln Gly Asp Pro Asp Ala Ala Ile Trp Leu Gly Asp Ser Leu
    1010                1015                1020                
Gly Ser Met Thr Gln Lys Ser Asp Leu Ser Ser Ser Ser Gly Ser Leu
1025                1030                1035                1040
Ser Leu Ser His Gly Ser Ser Ser Leu Glu His Arg Ser Glu Asp Ser
                1045                1050                1055    
Thr Ile Tyr Asp Leu Leu Lys Asp Pro Val Ser Leu Arg Ser Lys Ala
            1060                1065                1070        
Arg Arg Ala Lys Lys Ala Lys Ala Ser Ser Ala Leu Val Val Cys Gly
        1075                1080                1085            
Gly Gln Gly His Arg Arg Val His Arg Lys Ala Arg Gln Pro His Gln
    1090                1095                1100                
Glu Glu Leu Ala Pro Thr Val Met Val Trp Gln Ile Pro Leu Leu Asn
1105                1110                1115                1120
Ile
    


<210> 2439
<211> 191
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44,
45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58,
59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72,
73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86,
87
<223> Xaa = Any Amino Acid

<221> VARIANT        
<222> 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101,
102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113,
114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125,
126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136
<223> Xaa = Any Amino Acid

<221> VARIANT        
<222> 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148,
149, 150, 151, 152, 153, 154, 155
<223> Xaa = Any Amino Acid

<400> 2439
Met Asn Thr Leu Leu Ser Ser Leu Thr Ala Lys Thr Pro Arg Pro Ala
 1               5                  10                  15      
Pro Phe Ser Ser Gly Gly Leu Ala Lys Arg Phe Ser Arg Xaa Xaa Xaa
            20                  25                  30          
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
        35                  40                  45              
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    50                  55                  60                  
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
65                  70                  75                  80  
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
                85                  90                  95      
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            100                 105                 110         
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
        115                 120                 125             
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    130                 135                 140                 
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Gln Phe Cys Tyr
145                 150                 155                 160 
Cys Glu Leu Met Thr Ser Phe Gln Ala Thr Lys Arg Lys Ala Met Thr
                165                 170                 175     
Arg Ala Gly Lys Ala Gly Leu Leu Met Leu Ala Arg Ser Glu Cys
            180                 185                 190     


<210> 2440
<211> 282
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249,
250, 251, 252, 253, 254, 255, 256
<223> Xaa = Any Amino Acid

<400> 2440
Met Ser Gly Ser Ser Leu Pro Ser Ala Leu Ala Leu Ser Leu Leu Leu
 1               5                  10                  15      
Val Ser Gly Ser Leu Leu Pro Gly Pro Gly Ala Ala Gln Asn Glu Pro
            20                  25                  30          
Arg Ile Val Thr Ser Glu Glu Val Ile Ile Arg Asp Ser Pro Val Leu
        35                  40                  45              
Pro Val Thr Leu Gln Cys Asn Leu Thr Ser Ser Ser His Thr Leu Thr
    50                  55                  60                  
Tyr Ser Tyr Trp Thr Lys Asn Gly Val Glu Leu Ser Ala Thr Arg Lys
65                  70                  75                  80  
Asn Ala Ser Asn Met Glu Tyr Arg Ile Asn Lys Pro Arg Ala Glu Asp
                85                  90                  95      
Ser Gly Glu Tyr His Cys Val Tyr His Phe Val Ser Ala Pro Lys Ala
            100                 105                 110         
Asn Ala Thr Ile Glu Val Lys Ala Ala Pro Asp Ile Thr Gly His Lys
        115                 120                 125             
Arg Ser Glu Asn Lys Asn Glu Gly Gln Asp Ala Thr Met Tyr Cys Lys
    130                 135                 140                 
Ser Val Gly Tyr Pro His Pro Asp Trp Ile Trp Arg Lys Lys Glu Asn
145                 150                 155                 160 
Gly Met Pro Met Asp Ile Val Asn Thr Ser Gly Arg Phe Phe Ile Ile
                165                 170                 175     
Asn Lys Glu Asn Tyr Thr Glu Leu Asn Ile Val Asn Leu Gln Ile Thr
            180                 185                 190         
Glu Asp Pro Gly Glu Tyr Glu Cys Asn Ala Thr Asn Ala Ile Gly Ser
        195                 200                 205             
Ala Ser Val Val Thr Val Leu Arg Val Arg Ser His Leu Ala Pro Leu
    210                 215                 220                 
Trp Pro Phe Leu Gly Ile Leu Ala Glu Ile Ile Ile Leu Xaa Xaa Xaa
225                 230                 235                 240 
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
                245                 250                 255     
Asp Glu Pro Ala Gly Pro Met Lys Thr Asn Ser Thr Asn Asn His Lys
            260                 265                 270         
Asp Lys Asn Leu Arg Gln Arg Asn Thr Asn
        275                 280         


<210> 2441
<211> 208
<212> PRT
<213> Homo sapiens

<400> 2441
Met Lys Val Leu Leu Ala Ala Ala Leu Ile Ala Gly Ser Val Phe Phe
 1               5                  10                  15      
Leu Leu Leu Pro Gly Pro Ser Ala Ala Asp Glu Lys Lys Lys Gly Pro
            20                  25                  30          
Lys Val Thr Val Lys Val Tyr Phe Asp Leu Arg Ile Gly Asp Glu Asp
        35                  40                  45              
Val Gly Arg Val Ile Phe Gly Leu Phe Gly Lys Thr Val Pro Lys Thr
    50                  55                  60                  
Val Asp Asn Phe Val Ala Leu Ala Thr Gly Glu Lys Gly Phe Gly Tyr
65                  70                  75                  80  
Lys Asn Ser Lys Phe His Arg Val Ile Lys Asp Phe Met Ile Gln Gly
                85                  90                  95      
Gly Asp Phe Thr Arg Gly Asp Gly Thr Gly Gly Lys Ser Ile Tyr Gly
            100                 105                 110         
Glu Arg Phe Pro Asp Glu Asn Phe Lys Leu Lys His Tyr Gly Pro Gly
        115                 120                 125             
Trp Val Ser Met Ala Asn Ala Gly Lys Asp Thr Asn Gly Ser Gln Phe
    130                 135                 140                 
Phe Ile Thr Thr Val Lys Thr Ala Trp Leu Asp Gly Lys His Val Val
145                 150                 155                 160 
Phe Gly Lys Val Leu Glu Gly Met Glu Val Val Arg Lys Val Glu Ser
                165                 170                 175     
Thr Lys Thr Asp Ser Arg Asp Lys Pro Leu Lys Asp Val Ile Ile Ala
            180                 185                 190         
Asp Cys Gly Lys Ile Glu Val Glu Lys Pro Phe Ala Ile Ala Lys Glu
        195                 200                 205             


<210> 2442
<211> 136
<212> PRT
<213> Homo sapiens

<400> 2442
Met Ser Arg Thr Asn Arg Pro Pro Leu Ser Leu Ser Arg Met Ile Arg
 1               5                  10                  15      
Lys Met Lys Leu Pro Gly Arg Glu Asn Lys Thr Ala Val Val Val Gly
            20                  25                  30          
Thr Ile Thr Asp Asp Val Arg Val Gln Glu Val Pro Lys Leu Lys Val
        35                  40                  45              
Cys Ala Leu Arg Val Thr Ser Arg Ala Arg Ser Arg Ile Leu Arg Ala
    50                  55                  60                  
Gly Gly Lys Ile Leu Thr Phe Asp Gln Leu Ala Leu Asp Ser Pro Lys
65                  70                  75                  80  
Gly Cys Gly Thr Val Leu Leu Ser Gly Pro Arg Lys Gly Arg Glu Val
                85                  90                  95      
Tyr Arg His Phe Gly Lys Ala Pro Gly Thr Pro His Ser His Thr Lys
            100                 105                 110         
Pro Tyr Val Arg Ser Lys Gly Arg Lys Phe Glu Arg Ala Arg Gly Arg
        115                 120                 125             
Arg Ala Ser Arg Gly Tyr Lys Asn
    130                 135     


<210> 2443
<211> 474
<212> PRT
<213> Homo sapiens

<400> 2443
Met Leu Glu Pro Ala Leu Ala Thr Gly Glu Glu Leu Pro Glu Leu Thr
 1               5                  10                  15      
Leu Leu Thr Thr Leu Leu Glu Gly Pro Gly Asp Lys Thr Gln Pro Pro
            20                  25                  30          
Glu Glu Glu Thr Leu Ser Gln Ala Pro Glu Ser Glu Glu Glu Gln Lys
        35                  40                  45              
Lys Lys Ala Leu Glu Arg Ser Met Tyr Val Leu Ser Glu Leu Val Glu
    50                  55                  60                  
Thr Glu Lys Met Tyr Val Asp Asp Leu Gly Gln Ile Val Glu Gly Tyr
65                  70                  75                  80  
Met Ala Thr Met Ala Ala Gln Gly Val Pro Glu Ser Leu Arg Gly Arg
                85                  90                  95      
Asp Arg Ile Val Phe Gly Asn Ile Gln Gln Ile Tyr Glu Trp His Arg
            100                 105                 110         
Asp Tyr Phe Leu Gln Glu Leu Gln Arg Cys Leu Lys Asp Pro Asp Trp
        115                 120                 125             
Leu Ala Gln Leu Phe Ile Lys His Glu Arg Arg Leu His Met Tyr Val
    130                 135                 140                 
Val Tyr Cys Gln Asn Lys Pro Lys Ser Glu His Val Val Ser Glu Phe
145                 150                 155                 160 
Gly Asp Ser Tyr Phe Glu Glu Leu Arg Gln Gln Leu Gly His Arg Leu
                165                 170                 175     
Gln Leu Asn Asp Leu Leu Ile Lys Pro Val Gln Arg Ile Met Lys Tyr
            180                 185                 190         
Gln Leu Leu Leu Lys Asp Phe Leu Lys Tyr Tyr Asn Arg Ala Gly Met
        195                 200                 205             
Asp Thr Ala Asp Leu Glu Gln Ala Val Glu Val Met Cys Phe Val Pro
    210                 215                 220                 
Lys Arg Cys Asn Asp Met Met Thr Leu Gly Arg Leu Arg Gly Phe Glu
225                 230                 235                 240 
Gly Lys Leu Thr Ala Gln Gly Lys Leu Leu Gly Gln Asp Thr Phe Trp
                245                 250                 255     
Val Thr Glu Pro Glu Ala Gly Gly Leu Leu Ser Ser Arg Gly Arg Glu
            260                 265                 270         
Arg Arg Val Phe Leu Phe Glu Gln Ile Ile Ile Phe Ser Glu Ala Leu
        275                 280                 285             
Gly Gly Gly Val Arg Gly Gly Thr Gln Pro Gly Tyr Val Tyr Lys Asn
    290                 295                 300                 
Ser Ile Lys Val Ser Cys Leu Gly Leu Glu Gly Asn Leu Gln Gly Asp
305                 310                 315                 320 
Pro Cys Arg Phe Ala Leu Thr Ser Arg Gly Pro Glu Gly Gly Ile Gln
                325                 330                 335     
Arg Tyr Val Leu Gln Ala Ala Asp Pro Ala Ile Ser Gln Ala Trp Ile
            340                 345                 350         
Lys His Val Ala Gln Ile Leu Glu Ser Gln Arg Asp Phe Leu Asn Ala
        355                 360                 365             
Leu Gln Ser Pro Ile Glu Tyr Gln Arg Arg Glu Ser Gln Thr Asn Ser
    370                 375                 380                 
Leu Gly Arg Pro Arg Gly Pro Gly Val Gly Ser Pro Gly Arg Ile Gln
385                 390                 395                 400 
Leu Gly Asp Gln Ala Gln Gly Ser Thr His Thr Pro Ile Asn Gly Ser
                405                 410                 415     
Leu Pro Ser Leu Leu Leu Ser Pro Lys Gly Glu Val Ala Arg Ala Leu
            420                 425                 430         
Leu Pro Leu Asp Lys Gln Ala Leu Gly Asp Ile Pro Gln Ala Pro His
        435                 440                 445             
Asp Ser Pro Pro Val Ser Pro Thr Pro Lys Thr Pro Pro Cys Gln Ala
    450                 455                 460                 
Arg Leu Ala Lys Leu Asp Glu Asp Glu Leu
465                 470                 


<210> 2444
<211> 215
<212> PRT
<213> Homo sapiens

<400> 2444
Met Ser Arg Arg Cys Arg Arg Cys His His Pro Arg Gly Arg Arg Glu
 1               5                  10                  15      
Glu Glu Glu Cys Gly Ala Ala Ala Pro Gly Pro Arg Arg Asp Pro Asp
            20                  25                  30          
Met Glu Leu Arg Glu Glu Ala Trp Ser Pro Gly Pro Leu Asp Ser Glu
        35                  40                  45              
Asp Gln Gln Met Ala Ser His Glu Asn Pro Val Asp Ile Leu Ile Met
    50                  55                  60                  
Asp Asp Asp Asp Val Pro Ser Trp Pro Pro Thr Lys Leu Ser Pro Pro
65                  70                  75                  80  
Gln Ser Ala Pro Pro Ala Gly Pro Arg Gln Pro Trp Arg Ala Arg Gly
                85                  90                  95      
Gln Arg Pro Arg Gly Pro Gly Arg Gly Ala Pro Arg Pro Pro Ser Arg
            100                 105                 110         
Thr Cys Val Trp Ser Ala Gly Arg Ala Ser Gly Thr Gly Pro Gly Ser
        115                 120                 125             
Trp Arg Thr Ser Gly Pro Ser Thr Gly Thr Gly Ser Gly Arg Arg Gly
    130                 135                 140                 
Ala Arg Ser Arg Pro Thr Ser Ala Trp Ser Ala Gly Arg Ala Ser Cys
145                 150                 155                 160 
Arg Ala Pro Arg Ser Gly Asp Thr Arg Arg Ser Thr Arg Trp Ala Arg
                165                 170                 175     
Pro Arg Ser Ala Ala Ala Ala Asp Arg Ala Thr Thr Ala Arg Ala Gly
            180                 185                 190         
Arg Arg Arg Thr Thr Thr Thr Thr Arg Pro Arg Ala Gly Gly Ala Pro
        195                 200                 205             
Ser Ala Ala Val Gly Arg Ala
    210                 215 


<210> 2445
<211> 295
<212> PRT
<213> Homo sapiens

<400> 2445
Met Glu His Gln Leu Leu Cys Cys Glu Val Glu Thr Ile Arg Arg Ala
 1               5                  10                  15      
Tyr Pro Asp Ala Asn Leu Leu Asn Asp Arg Val Leu Arg Ala Met Leu
            20                  25                  30          
Lys Ala Glu Glu Thr Cys Ala Pro Ser Val Ser Tyr Phe Lys Cys Val
        35                  40                  45              
Gln Lys Glu Val Leu Pro Ser Met Arg Lys Ile Val Ala Thr Trp Met
    50                  55                  60                  
Leu Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu
65                  70                  75                  80  
Ala Met Asn Tyr Leu Asp Arg Phe Leu Ser Leu Glu Pro Val Lys Lys
                85                  90                  95      
Ser Arg Leu Gln Leu Leu Gly Ala Thr Cys Met Phe Val Ala Ser Lys
            100                 105                 110         
Met Lys Glu Thr Ile Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr
        115                 120                 125             
Asp Asn Ser Ile Arg Pro Glu Glu Leu Leu Gln Met Glu Leu Leu Leu
    130                 135                 140                 
Val Asn Lys Leu Lys Trp Asn Leu Ala Ala Met Thr Pro His Asp Phe
145                 150                 155                 160 
Ile Glu His Phe Leu Ser Lys Met Pro Glu Ala Glu Glu Asn Lys Gln
                165                 170                 175     
Ile Ile Arg Lys His Ala Gln Thr Phe Val Ala Leu Cys Ala Thr Asp
            180                 185                 190         
Val Lys Phe Ile Ser Asn Pro Pro Ser Met Val Ala Ala Gly Ser Val
        195                 200                 205             
Val Ala Ala Val Gln Gly Leu Asn Leu Arg Ser Pro Asn Asn Phe Leu
    210                 215                 220                 
Ser Tyr Tyr Arg Leu Thr Arg Phe Leu Ser Arg Val Ile Lys Cys Asp
225                 230                 235                 240 
Pro Asp Cys Leu Arg Ala Cys Gln Glu Gln Ile Glu Ala Leu Leu Glu
                245                 250                 255     
Ser Ser Leu Arg Gln Ala Gln Gln Asn Met Asp Pro Lys Ala Ala Glu
            260                 265                 270         
Glu Glu Glu Glu Glu Glu Glu Glu Val Asp Leu Ala Cys Thr Pro Thr
        275                 280                 285             
Asp Val Arg Asp Val Asp Ile
    290                 295 


<210> 2446
<211> 426
<212> PRT
<213> Homo sapiens

<400> 2446
Met Met Pro Thr Glu Glu Glu Arg Gln Lys Ile Glu Glu Ala Gln Leu
 1               5                  10                  15      
Ala Asn Pro Asp Ile Pro Leu Gly Pro Ala Glu Asn Phe Leu Met Thr
            20                  25                  30          
Leu Ala Ser Ile Gly Gly Leu Ala Ala Arg Leu Gln Leu Trp Ala Phe
        35                  40                  45              
Lys Leu Asp Tyr Asp Ser Met Glu Arg Glu Ile Ala Glu Pro Leu Phe
    50                  55                  60                  
Asp Leu Lys Val Gly Met Glu Gln Leu Val Gln Asn Ala Thr Phe Arg
65                  70                  75                  80  
Cys Ile Leu Ala Thr Leu Leu Ala Val Gly Asn Phe Leu Asn Gly Ser
                85                  90                  95      
Gln Ser Ser Gly Phe Glu Leu Ser Tyr Leu Glu Lys Val Ser Glu Val
            100                 105                 110         
Lys Asp Thr Val Arg Arg Gln Ser Leu Leu His His Leu Cys Ser Leu
        115                 120                 125             
Val Leu Gln Thr Arg Pro Glu Ser Ser Asp Leu Tyr Ser Glu Ile Pro
    130                 135                 140                 
Ala Leu Thr Arg Cys Ala Lys Val Asp Phe Glu Gln Leu Thr Glu Asn
145                 150                 155                 160 
Leu Gly Gln Leu Glu Arg Arg Ser Arg Ala Ala Glu Glu Ser Leu Arg
                165                 170                 175     
Ser Leu Ala Lys His Glu Leu Ala Pro Ala Leu Arg Ala Arg Leu Thr
            180                 185                 190         
His Phe Leu Asp Gln Cys Ala Arg Arg Val Ala Met Leu Arg Ile Val
        195                 200                 205             
His Arg Arg Val Cys Asn Arg Phe His Ala Phe Leu Leu Tyr Leu Gly
    210                 215                 220                 
Tyr Thr Pro Gln Ala Ala Arg Glu Val Arg Ile Met Gln Phe Cys His
225                 230                 235                 240 
Thr Leu Arg Glu Phe Ala Leu Glu Tyr Arg Thr Cys Arg Glu Arg Val
                245                 250                 255     
Leu Gln Gln Gln Gln Lys Gln Ala Thr Tyr Arg Glu Arg Asn Lys Thr
            260                 265                 270         
Arg Gly Arg Met Ile Thr Glu Thr Glu Lys Phe Ser Gly Val Ala Gly
        275                 280                 285             
Glu Ala Pro Ser Asn Pro Ser Val Pro Val Ala Val Ser Ser Gly Pro
    290                 295                 300                 
Gly Arg Gly Asp Ala Asp Ser His Ala Ser Met Lys Ser Leu Leu Thr
305                 310                 315                 320 
Ser Arg Pro Glu Asp Thr Thr His Asn Arg Arg Ser Arg Gly Met Val
                325                 330                 335     
Gln Ser Ser Ser Pro Ile Met Pro Thr Val Gly Pro Ser Thr Ala Ser
            340                 345                 350         
Pro Glu Glu Pro Pro Gly Ser Ser Leu Pro Ser Asp Thr Ser Asp Glu
        355                 360                 365             
Ile Met Asp Leu Leu Val Gln Ser Val Thr Lys Ser Ser Pro Arg Ala
    370                 375                 380                 
Leu Ala Ala Arg Glu Arg Lys Arg Ser Arg Gly Asn Arg Lys Ser Leu
385                 390                 395                 400 
Arg Arg Thr Leu Lys Ser Gly Leu Gly Asp Asp Leu Val Gln Ala Leu
                405                 410                 415     
Gly Leu Ser Lys Gly Pro Gly Leu Glu Val
            420                 425     


<210> 2447
<211> 862
<212> PRT
<213> Homo sapiens

<400> 2447
Met Ala Gln Pro Gly Pro Ala Ser Gln Pro Asp Val Ser Leu Gln Gln
 1               5                  10                  15      
Arg Val Ala Glu Leu Glu Lys Ile Asn Ala Glu Phe Leu Arg Ala Gln
            20                  25                  30          
Gln Gln Leu Glu Gln Glu Phe Asn Gln Lys Arg Ala Lys Phe Lys Glu
        35                  40                  45              
Leu Tyr Leu Ala Lys Glu Glu Asp Leu Lys Arg Gln Asn Ala Val Leu
    50                  55                  60                  
Gln Ala Ala Gln Asp Asp Leu Gly His Leu Arg Thr Gln Leu Trp Glu
65                  70                  75                  80  
Ala Gln Ala Glu Met Glu Asn Ile Lys Ala Ile Ala Thr Val Ser Glu
                85                  90                  95      
Asn Thr Lys Gln Glu Ala Ile Asp Glu Val Lys Arg Gln Trp Arg Glu
            100                 105                 110         
Glu Val Ala Ser Leu Gln Ala Val Met Lys Glu Thr Val Arg Asp Tyr
        115                 120                 125             
Glu His Gln Phe His Leu Arg Leu Glu Gln Glu Arg Thr Gln Trp Ala
    130                 135                 140                 
Gln Tyr Arg Glu Ser Ala Glu Arg Glu Ile Ala Asp Leu Arg Arg Arg
145                 150                 155                 160 
Leu Ser Glu Gly Gln Glu Glu Glu Asn Leu Glu Asn Glu Met Lys Lys
                165                 170                 175     
Ala Gln Glu Asp Ala Glu Lys Leu Arg Ser Val Val Met Pro Met Glu
            180                 185                 190         
Lys Glu Ile Ala Ala Leu Lys Asp Lys Leu Thr Glu Ala Glu Asp Lys
        195                 200                 205             
Ile Lys Glu Leu Glu Ala Ser Lys Val Lys Glu Leu Asn His Tyr Leu
    210                 215                 220                 
Glu Ala Glu Lys Ser Cys Arg Thr Asp Leu Glu Met Tyr Val Ala Val
225                 230                 235                 240 
Leu Asn Thr Gln Lys Ser Val Leu Gln Glu Asp Ala Glu Lys Leu Arg
                245                 250                 255     
Lys Glu Leu His Glu Val Cys His Leu Leu Glu Gln Glu Arg Gln Gln
            260                 265                 270         
His Asn Gln Leu Lys His Thr Trp Gln Lys Ala Asn Asp Gln Phe Leu
        275                 280                 285             
Glu Ser Gln Arg Leu Leu Met Arg Asp Met Gln Arg Met Glu Ile Val
    290                 295                 300                 
Leu Thr Ser Glu Gln Leu Arg Gln Val Glu Glu Leu Lys Lys Lys Asp
305                 310                 315                 320 
Gln Glu Asp Asp Glu Gln Gln Arg Leu Asn Lys Arg Lys Asp His Lys
                325                 330                 335     
Lys Ala Asp Val Glu Glu Glu Ile Lys Ile Pro Val Val Cys Ala Leu
            340                 345                 350         
Thr Gln Glu Glu Ser Ser Ala Gln Leu Ser Asn Glu Glu Glu His Leu
        355                 360                 365             
Asp Ser Thr Arg Gly Ser Val His Ser Leu Asp Ala Gly Leu Leu Leu
    370                 375                 380                 
Pro Ser Gly Asp Pro Phe Ser Lys Ser Asp Asn Asp Met Phe Lys Asp
385                 390                 395                 400 
Gly Leu Arg Arg Ala Gln Ser Thr Asp Ser Leu Gly Thr Ser Gly Ser
                405                 410                 415     
Leu Gln Ser Lys Ala Leu Gly Tyr Asn Tyr Lys Ala Lys Ser Ala Gly
            420                 425                 430         
Asn Leu Asp Glu Ser Asp Phe Gly Pro Leu Val Gly Ala Asp Ser Val
        435                 440                 445             
Ser Glu Asn Phe Asp Thr Ala Ser Leu Gly Ser Leu Gln Met Pro Ser
    450                 455                 460                 
Gly Phe Met Leu Thr Lys Asp Gln Glu Arg Ala Ile Lys Ala Met Thr
465                 470                 475                 480 
Pro Glu Gln Glu Glu Thr Ala Ser Leu Leu Ser Ser Val Thr Gln Gly
                485                 490                 495     
Met Glu Ser Ala Tyr Val Ser Pro Ser Gly Tyr Arg Leu Val Ser Glu
            500                 505                 510         
Thr Glu Trp Asn Leu Leu Gln Lys Glu Val His Asn Ala Gly Asn Lys
        515                 520                 525             
Leu Gly Arg Arg Cys Asp Met Cys Ser Asn Tyr Glu Lys Gln Leu Gln
    530                 535                 540                 
Gly Ile Gln Ile Gln Glu Ala Glu Thr Arg Asp Gln Val Lys Lys Leu
545                 550                 555                 560 
Gln Leu Met Leu Arg Gln Ala Asn Asp Gln Leu Glu Lys Thr Met Lys
                565                 570                 575     
Asp Lys Gln Glu Leu Glu Asp Phe Ile Lys Gln Ser Ser Glu Asp Ser
            580                 585                 590         
Ser His Gln Ile Ser Ala Leu Val Leu Arg Ala Gln Ala Ser Glu Ile
        595                 600                 605             
Leu Leu Glu Glu Leu Gln Gln Gly Leu Ser Gln Ala Lys Arg Asp Val
    610                 615                 620                 
Gln Glu Gln Met Ala Val Leu Met Gln Ser Arg Glu Gln Val Ser Glu
625                 630                 635                 640 
Glu Leu Val Arg Leu Gln Lys Asp Asn Asp Ser Leu Gln Gly Lys His
                645                 650                 655     
Ser Leu His Val Ser Leu Gln Gln Ala Glu Asp Phe Ile Leu Pro Asp
            660                 665                 670         
Thr Thr Glu Ala Leu Arg Glu Leu Val Leu Lys Tyr Arg Glu Asp Ile
        675                 680                 685             
Ile Asn Val Arg Thr Ala Ala Asp His Val Glu Glu Lys Leu Lys Ala
    690                 695                 700                 
Glu Ile Leu Phe Leu Lys Glu Gln Ile Gln Ala Glu Gln Cys Leu Lys
705                 710                 715                 720 
Glu Asn Leu Glu Glu Thr Leu Gln Leu Glu Ile Glu Asn Cys Lys Glu
                725                 730                 735     
Glu Ile Ala Ser Ile Ser Ser Leu Lys Ala Glu Leu Glu Arg Ile Lys
            740                 745                 750         
Val Glu Lys Gly Gln Leu Glu Ser Thr Leu Arg Glu Lys Ser Gln Gln
        755                 760                 765             
Leu Glu Ser Leu Gln Glu Ile Lys Ile Ser Leu Glu Glu Gln Leu Lys
    770                 775                 780                 
Lys Glu Thr Ala Ala Lys Ala Thr Val Glu Gln Leu Met Phe Glu Glu
785                 790                 795                 800 
Lys Asn Lys Ala Gln Arg Leu Gln Thr Glu Leu Asp Val Ser Glu Gln
                805                 810                 815     
Val Gln Arg Asp Phe Val Lys Leu Ser Gln Thr Leu Gln Val Gln Leu
            820                 825                 830         
Glu Arg Ile Arg Gln Ala Asp Ser Leu Glu Arg Ile Arg Ala Ile Leu
        835                 840                 845             
Asn Asp Thr Lys Leu Thr Asp Ile Asn Gln Leu Pro Glu Thr
    850                 855                 860         


<210> 2448
<211> 1056
<212> PRT
<213> Homo sapiens

<400> 2448
Met Ala Gly Gly Arg Gly Ser Gly Gly His Ala Leu His Ala Gly Ser
 1               5                  10                  15      
Glu Gly Val Lys Leu Leu Ala Thr Val Leu Ser Gln Lys Ser Val Ser
            20                  25                  30          
Glu Ser Gly Pro Gly Asp Ser Pro Ala Lys Pro Pro Glu Gly Ser Ala
        35                  40                  45              
Gly Val Ala Arg Ser Gln Pro Pro Val Ala His Ala Gly Gln Val Tyr
    50                  55                  60                  
Gly Glu Gln Pro Pro Lys Lys Leu Glu Pro Ala Ser Glu Gly Lys Ser
65                  70                  75                  80  
Ser Glu Ala Val Ser Gln Trp Leu Thr Ala Phe Gln Leu Gln Leu Tyr
                85                  90                  95      
Ala Pro Asn Phe Ile Ser Ala Gly Tyr Asp Leu Pro Thr Ile Ser Arg
            100                 105                 110         
Met Thr Pro Glu Asp Leu Thr Ala Ile Gly Val Thr Lys Pro Gly His
        115                 120                 125             
Arg Lys Lys Ile Ala Ala Glu Ile Ser Gly Leu Ser Ile Pro Asp Trp
    130                 135                 140                 
Leu Pro Glu His Lys Pro Ala Asn Leu Ala Val Trp Leu Ser Met Ile
145                 150                 155                 160 
Gly Leu Ala Gln Tyr Tyr Lys Val Leu Val Asp Asn Gly Tyr Glu Asn
                165                 170                 175     
Ile Asp Phe Ile Thr Asp Ile Thr Trp Glu Asp Leu Gln Glu Ile Gly
            180                 185                 190         
Ile Thr Lys Leu Gly His Gln Lys Lys Leu Met Leu Ala Val Arg Lys
        195                 200                 205             
Leu Ala Glu Leu Gln Lys Ala Glu Tyr Ala Lys Tyr Glu Gly Gly Pro
    210                 215                 220                 
Leu Arg Arg Lys Ala Pro Gln Ser Leu Glu Val Met Ala Ile Glu Ser
225                 230                 235                 240 
Pro Pro Pro Pro Glu Pro Thr Pro Ala Asp Cys Gln Ser Pro Lys Met
                245                 250                 255     
Thr Thr Phe Gln Asp Ser Glu Leu Ser Asp Glu Leu Gln Ala Ala Met
            260                 265                 270         
Thr Gly Pro Ala Glu Val Gly Pro Thr Thr Glu Lys Pro Ser Ser His
        275                 280                 285             
Leu Pro Pro Thr Pro Arg Ala Thr Thr Arg Gln Asp Ser Ser Leu Gly
    290                 295                 300                 
Gly Arg Ala Arg His Met Ser Ser Ser Gln Glu Leu Leu Gly Asp Gly
305                 310                 315                 320 
Pro Pro Gly Pro Ser Ser Pro Met Ser Arg Ser Gln Glu Tyr Leu Leu
                325                 330                 335     
Asp Glu Gly Pro Ala Pro Gly Thr Pro Pro Arg Glu Ala Arg Pro Gly
            340                 345                 350         
Arg His Gly His Ser Ile Lys Arg Ala Ser Val Pro Pro Val Pro Gly
        355                 360                 365             
Lys Pro Arg Gln Val Leu Pro Pro Gly Thr Ser His Phe Thr Pro Pro
    370                 375                 380                 
Gln Thr Pro Thr Lys Thr Arg Pro Gly Ser Pro Gln Ala Leu Gly Gly
385                 390                 395                 400 
Pro His Gly Pro Ala Pro Ala Thr Ala Lys Val Lys Pro Thr Pro Gln
                405                 410                 415     
Leu Leu Pro Pro Thr Glu Arg Pro Met Ser Pro Arg Ser Leu Pro Gln
            420                 425                 430         
Ser Pro Thr His Arg Gly Phe Ala Tyr Val Leu Pro Gln Pro Val Glu
        435                 440                 445             
Gly Glu Val Gly Pro Ala Ala Pro Gly Pro Ala Pro Pro Pro Val Pro
    450                 455                 460                 
Thr Ala Val Pro Thr Leu Cys Leu Pro Pro Glu Ala Asp Ala Glu Pro
465                 470                 475                 480 
Gly Arg Pro Lys Lys Arg Ala His Ser Leu Asn Arg Tyr Ala Ala Ser
                485                 490                 495     
Asp Ser Glu Pro Glu Arg Asp Glu Leu Leu Val Pro Ala Ala Ala Gly
            500                 505                 510         
Pro Tyr Ala Thr Val Gln Arg Arg Val Gly Arg Ser His Ser Val Arg
        515                 520                 525             
Ala Pro Ala Gly Ala Asp Lys Asn Val Asn Arg Ser Gln Ser Phe Ala
    530                 535                 540                 
Val Arg Pro Arg Lys Lys Gly Pro Pro Pro Pro Pro Pro Lys Arg Ser
545                 550                 555                 560 
Ser Ser Ala Leu Ala Ser Ala Asn Leu Ala Asp Glu Pro Val Pro Asp
                565                 570                 575     
Ala Glu Pro Glu Asp Gly Leu Leu Gly Val Arg Ala Gln Cys Arg Arg
            580                 585                 590         
Ala Ser Asp Leu Ala Gly Ser Val Asp Thr Gly Ser Ala Gly Ser Val
        595                 600                 605             
Lys Ser Ile Ala Ala Met Leu Glu Leu Ser Ser Ile Gly Gly Gly Gly
    610                 615                 620                 
Arg Ala Ala Arg Arg Pro Pro Glu Gly His Pro Thr Pro Arg Pro Ala
625                 630                 635                 640 
Ser Pro Glu Pro Gly Arg Val Ala Thr Val Leu Ala Ser Val Lys His
                645                 650                 655     
Lys Glu Ala Ile Gly Pro Gly Gly Glu Val Val Asn Arg Arg Arg Thr
            660                 665                 670         
Leu Ser Gly Pro Val Thr Gly Leu Leu Ala Thr Ala Arg Arg Gly Pro
        675                 680                 685             
Gly Glu Ser Ala Asp Pro Gly Pro Phe Val Glu Asp Gly Thr Gly Arg
    690                 695                 700                 
Gln Arg Pro Arg Gly Pro Ser Lys Gly Glu Ala Gly Val Glu Gly Pro
705                 710                 715                 720 
Pro Leu Ala Lys Val Glu Ala Ser Ala Thr Leu Lys Arg Arg Ile Arg
                725                 730                 735     
Ala Lys Gln Asn Gln Gln Glu Asn Val Lys Phe Ile Leu Thr Glu Ser
            740                 745                 750         
Asp Thr Val Lys Arg Arg Pro Lys Ala Lys Glu Arg Glu Ala Gly Pro
        755                 760                 765             
Glu Pro Pro Pro Pro Leu Ser Val Tyr His Asn Gly Thr Gly Thr Val
    770                 775                 780                 
Arg Arg Arg Pro Ala Ser Glu Gln Ala Gly Pro Pro Glu Leu Pro Pro
785                 790                 795                 800 
Pro Pro Pro Pro Ala Glu Pro Pro Pro Thr Asp Leu Ala His Leu Pro
                805                 810                 815     
Pro Leu Pro Pro Pro Glu Gly Glu Ala Arg Lys Pro Ala Lys Pro Pro
            820                 825                 830         
Val Ser Pro Lys Pro Val Leu Thr Gln Pro Val Pro Lys Leu Gln Gly
        835                 840                 845             
Ser Pro Thr Pro Thr Ser Lys Lys Val Pro Leu Pro Gly Pro Trp Gln
    850                 855                 860                 
Pro Arg Gly Glu Ala Arg Pro Arg His Ala Thr Ala Arg Val Ser Gln
865                 870                 875                 880 
Ala Ala Ala Ala Ala His Ser Ala Gln Ala Arg Gln Gly Gly Arg Gly
                885                 890                 895     
Ala Ala Phe Gly Gln Arg Arg Pro Phe Thr Arg Thr Leu Ala Arg Ala
            900                 905                 910         
Thr Ala Ala Arg Arg Pro Arg Gln Ala Ala Arg Tyr Ala Ala Leu Ala
        915                 920                 925             
Gly Arg Gln Pro Arg Gln Ala Pro Val Pro Arg Arg Ala Arg Ala Ala
    930                 935                 940                 
Arg Ala Arg Gln Ala Pro Ala Ser Arg Arg Arg Arg Arg Arg Arg Arg
945                 950                 955                 960 
Arg Arg Ala Pro Arg Pro Ala Arg Arg Arg Leu Val Arg Gly Gln Arg
                965                 970                 975     
Pro Ala Glu Thr Gly Gly Asp Lys Arg Val Pro Cys Arg Gly Ala Ala
            980                 985                 990         
Gly Gly Gly Gly Glu Asp Pro Ala Gly Gly Arg Ala Gly Pro Ala Ala
        995                 1000                1005            
Thr Arg Arg Arg Lys Arg Ala Leu Ala Ala Ser Trp Thr Thr Ser Ala
    1010                1015                1020                
Ala Cys Ser Thr Thr Trp Pro Thr Ser Trp Met Pro Cys Trp Ser Glu
1025                1030                1035                1040
Arg Arg Leu Ala Gly Pro Ser Arg Ala Ala Arg Ala Leu Pro Ala His
                1045                1050                1055    


<210> 2449
<211> 635
<212> PRT
<213> Homo sapiens

<400> 2449
Met Ile Ile Thr Ile Ile Leu Glu Met Arg Lys Leu Glu Cys Ser Thr
 1               5                  10                  15      
Val Pro Pro Leu Thr Lys Val Asp Val Lys Met Glu Thr Ile Glu Arg
            20                  25                  30          
Lys Ile Ser Val Arg Glu Gln Thr Met Ser Glu Lys Glu Glu Leu Asn
        35                  40                  45              
Lys Lys Lys Arg Asn Met Gly Asp Val Ser Met His Gly Leu Pro Leu
    50                  55                  60                  
Val Gln Asp Gln Glu Asp Ser Glu Gly Asp Ile Ser Lys Asp Pro Asp
65                  70                  75                  80  
Lys Gln Leu Ala Gln Lys Phe Lys Thr Tyr Glu Leu Thr Leu Lys Asp
                85                  90                  95      
Val Gln Asn Ile Leu Met Tyr Trp Asp Arg Lys Gln Gly Val Gln Leu
            100                 105                 110         
Pro Pro Ala Gly Met Glu Glu Ala Pro His Glu Pro Asp Asp Gln Arg
        115                 120                 125             
Gln Val Pro Ser Gly Gly Arg Arg Gly Arg Lys Asp Arg Glu Arg Glu
    130                 135                 140                 
Arg Leu Glu Lys Glu Arg Leu Glu Arg Glu Glu Ala Glu Arg Glu Arg
145                 150                 155                 160 
Leu Glu Lys Leu Arg Asp Leu Glu Glu Arg Ser Asp Trp Glu Gly Glu
                165                 170                 175     
Gly Glu Glu Asp His Glu Glu Lys Lys Glu Lys Asp Leu Gly Val Pro
            180                 185                 190         
Phe Leu Asn Ile Gln Thr Pro Asp Phe Glu Gly Leu Ser Trp Lys Gln
        195                 200                 205             
Ala Leu Glu Ser Asp Arg Leu Pro Lys Gly Glu Gln Ala Gln Glu Glu
    210                 215                 220                 
Gln Thr Ser Ser Ser Lys Gly Gly Lys Gln Lys Met Lys Glu Lys Ile
225                 230                 235                 240 
Asp Gln Val Phe Glu Ser Gln Lys Asp Lys Arg His Met Ala Leu Asn
                245                 250                 255     
Arg Lys Val Leu Ser Gly Glu Pro Ala Gly Thr Ile Ser Gln Leu Ser
            260                 265                 270         
Asp Thr Asp Leu Asp Asn Phe Asn Gly Gln His Ser Gln Glu Lys Phe
        275                 280                 285             
Thr Arg Leu Asn His Phe Arg Trp Ile Val Pro Ala Asn Gly Glu Val
    290                 295                 300                 
Thr Leu Gln Val His Phe Ser Ser Asp Glu Phe Gly Asn Phe Asp Gln
305                 310                 315                 320 
Thr Phe Asn Phe Glu Ile Leu Gly Thr Cys Cys Gln Tyr Gln Leu Tyr
                325                 330                 335     
Cys Arg Gly Ile Cys Thr Tyr Pro Tyr Ile Cys Gln Asp Pro Lys Val
            340                 345                 350         
Val Phe Pro Gln Arg Lys Met Asp Met Lys Thr Asn Glu Val Ile Phe
        355                 360                 365             
Lys Lys Tyr Val Met Ser Thr Glu Thr Tyr Tyr Phe Gly Pro Leu Leu
    370                 375                 380                 
Cys Gly Lys Ser Arg Asp Lys Tyr Lys Ser Ser Leu Phe Pro Gly Asn
385                 390                 395                 400 
Met Glu Thr Leu Thr Ile Leu Asn Thr Ser Leu Met Val Val Glu Ala
                405                 410                 415     
Ser Phe Tyr Phe Gln Asn Asp Val Lys Ala Asn Thr Tyr Phe Leu Glu
            420                 425                 430         
Pro Asn Thr Met Val Leu Lys Pro Asn Glu Lys Gln Ile Leu Asn Val
        435                 440                 445             
Trp Ala Tyr Pro Thr Ser Val Gly Val Phe Glu Asp Ser Ile Val Cys
    450                 455                 460                 
Cys Ile Asn Asp Asn Pro Glu Pro Ala Ile Phe Gln Leu Ser Cys Gln
465                 470                 475                 480 
Gly Ile Arg Pro Glu Leu Glu Leu Glu Pro Arg Gln Leu His Phe Asp
                485                 490                 495     
Arg Leu Leu Leu His Arg Gln Glu Ser Arg Val Val Leu Leu Arg Asn
            500                 505                 510         
Val Thr Leu Leu Pro Val Ala Trp Arg Ile Thr Ser Leu Glu His Leu
        515                 520                 525             
Gly Asp Asp Phe Thr Val Ser Leu Met Gln Gly Thr Ile Pro Pro Glu
    530                 535                 540                 
Ala Glu Tyr Gly Leu His Leu Tyr Phe Gln Pro Thr Lys Pro Val Asn
545                 550                 555                 560 
Ile Lys Lys Ala Ile Arg Leu Glu Val Leu Asp Ala Glu Asn Leu Leu
                565                 570                 575     
Gly Val Val Gln Ile Glu Asn Ile Met Val Phe Ala Glu Ala Tyr Asp
            580                 585                 590         
Ile Ala Leu Asp Ile Thr Phe Pro Lys Gly Ala Glu Gly Gly Leu Asp
        595                 600                 605             
Phe Gly Ile Val Arg Val Thr Glu Glu Ala Lys Gln Pro Leu Gln Leu
    610                 615                 620                 
Lys Asn Arg Gly Lys Tyr Glu Ile Ala Phe Arg
625                 630                 635 


<210> 2450
<211> 1238
<212> PRT
<213> Homo sapiens

<400> 2450
Met Thr Ser Leu Arg Trp Leu Lys Leu Asn Arg Thr Gly Leu Cys Tyr
 1               5                  10                  15      
Leu Pro Glu Glu Leu Ala Ala Leu Gln Lys Leu Glu His Leu Ser Val
            20                  25                  30          
Ser His Asn Asn Leu Thr Thr Leu His Gly Glu Leu Ser Ser Leu Pro
        35                  40                  45              
Ser Leu Arg Ala Ile Val Ala Arg Ala Asn Ser Leu Lys Asn Ser Gly
    50                  55                  60                  
Val Pro Asp Asp Ile Phe Lys Leu Asp Asp Leu Ser Val Leu Asp Leu
65                  70                  75                  80  
Ser His Asn Gln Leu Thr Glu Cys Pro Arg Glu Leu Glu Asn Ala Lys
                85                  90                  95      
Asn Met Leu Val Leu Asn Leu Ser His Asn Ser Ile Asp Thr Ile Pro
            100                 105                 110         
Asn Gln Leu Phe Ile Asn Leu Thr Asp Leu Leu Tyr Leu Asp Leu Ser
        115                 120                 125             
Glu Asn Arg Leu Glu Ser Leu Pro Pro Gln Met Arg Arg Leu Val His
    130                 135                 140                 
Leu Gln Thr Leu Val Leu Asn Gly Asn Pro Leu Leu His Ala Gln Leu
145                 150                 155                 160 
Arg Gln Leu Pro Ala Met Thr Ala Leu Gln Thr Leu His Leu Arg Ser
                165                 170                 175     
Thr Gln Arg Thr Gln Ser Asn Leu Pro Thr Ser Leu Glu Gly Leu Ser
            180                 185                 190         
Asn Leu Ala Asp Val Asp Leu Ser Cys Asn Asp Leu Thr Arg Val Pro
        195                 200                 205             
Glu Cys Leu Tyr Thr Leu Pro Ser Leu Arg Arg Leu Asn Leu Ser Ser
    210                 215                 220                 
Asn Gln Ile Thr Glu Leu Ser Leu Cys Ile Asp Gln Trp Val His Val
225                 230                 235                 240 
Glu Thr Leu Asn Leu Ser Arg Asn Gln Leu Thr Ser Leu Pro Ser Ala
                245                 250                 255     
Ile Cys Lys Leu Ser Lys Leu Lys Lys Leu Tyr Leu Asn Ser Asn Lys
            260                 265                 270         
Leu Asp Phe Asp Gly Leu Pro Ser Gly Ile Gly Lys Leu Thr Asn Leu
        275                 280                 285             
Glu Glu Phe Met Ala Ala Asn Asn Asn Leu Glu Leu Val Pro Glu Ser
    290                 295                 300                 
Leu Cys Arg Cys Pro Lys Leu Arg Lys Leu Val Leu Asn Lys Asn His
305                 310                 315                 320 
Leu Val Thr Leu Pro Glu Ala Ile His Phe Leu Thr Glu Ile Glu Val
                325                 330                 335     
Leu Asp Val Arg Glu Asn Pro Asn Leu Val Met Pro Pro Lys Pro Ala
            340                 345                 350         
Asp Arg Ala Ala Glu Trp Tyr Asn Ile Asp Phe Ser Leu Gln Asn Gln
        355                 360                 365             
Leu Arg Leu Ala Gly Ala Ser Pro Ala Thr Val Ala Ala Ala Ala Ala
    370                 375                 380                 
Ala Gly Ser Gly Pro Lys Asp Pro Met Ala Arg Lys Met Arg Leu Arg
385                 390                 395                 400 
Arg Arg Lys Asp Ser Ala Gln Asp Asp Gln Ala Lys Gln Val Leu Lys
                405                 410                 415     
Gly Met Ser Asp Val Ala Gln Glu Lys Asn Lys Lys Gln Glu Glu Ser
            420                 425                 430         
Ala Asp Ala Arg Ala Pro Ser Gly Lys Val Arg Arg Trp Asp Gln Gly
        435                 440                 445             
Leu Glu Lys Pro Arg Leu Asp Tyr Ser Glu Phe Phe Thr Glu Asp Val
    450                 455                 460                 
Gly Gln Leu Pro Gly Leu Thr Ile Trp Gln Ile Glu Asn Phe Val Pro
465                 470                 475                 480 
Val Leu Val Glu Glu Ala Phe His Gly Lys Phe Tyr Glu Ala Asp Cys
                485                 490                 495     
Tyr Ile Val Leu Lys Thr Phe Leu Asp Asp Ser Gly Ser Leu Asn Trp
            500                 505                 510         
Glu Ile Tyr Tyr Trp Ile Gly Gly Glu Ala Thr Leu Asp Lys Lys Ala
        515                 520                 525             
Cys Ser Ala Ile His Ala Val Asn Leu Arg Asn Tyr Leu Gly Ala Glu
    530                 535                 540                 
Cys Arg Thr Val Arg Glu Glu Met Gly Asp Glu Ser Glu Glu Phe Leu
545                 550                 555                 560 
Gln Val Phe Asp Asn Asp Ile Ser Tyr Ile Glu Gly Gly Thr Ala Ser
                565                 570                 575     
Gly Phe Tyr Thr Val Glu Asp Thr His Tyr Val Thr Arg Met Tyr Arg
            580                 585                 590         
Val Tyr Gly Lys Lys Asn Ile Lys Leu Glu Pro Val Pro Leu Lys Gly
        595                 600                 605             
Thr Ser Leu Asp Pro Arg Phe Val Phe Leu Leu Asp Arg Gly Leu Asp
    610                 615                 620                 
Ile Tyr Val Trp Arg Gly Ala Gln Ala Thr Leu Ser Ser Thr Thr Lys
625                 630                 635                 640 
Ala Arg Leu Phe Ala Glu Lys Ile Asn Lys Asn Glu Arg Lys Gly Lys
                645                 650                 655     
Ala Glu Ile Thr Leu Leu Val Gln Gly Gln Glu Leu Pro Glu Phe Trp
            660                 665                 670         
Glu Ala Leu Gly Gly Glu Pro Ser Glu Ile Lys Lys His Val Pro Glu
        675                 680                 685             
Asp Phe Trp Pro Pro Gln Pro Lys Leu Tyr Lys Val Gly Leu Gly Leu
    690                 695                 700                 
Gly Tyr Leu Glu Leu Pro Gln Ile Asn Tyr Lys Leu Ser Val Glu His
705                 710                 715                 720 
Lys Gln Arg Pro Lys Val Glu Leu Met Pro Arg Met Arg Leu Leu Gln
                725                 730                 735     
Ser Leu Leu Asp Thr Arg Cys Val Tyr Ile Leu Asp Cys Trp Ser Asp
            740                 745                 750         
Val Phe Ile Trp Leu Gly Arg Lys Ser Pro Arg Leu Val Arg Ala Ala
        755                 760                 765             
Ala Leu Lys Leu Gly Gln Glu Leu Cys Gly Met Leu His Arg Pro Arg
    770                 775                 780                 
His Ala Thr Val Ser Arg Ser Leu Glu Gly Thr Glu Ala Gln Val Phe
785                 790                 795                 800 
Lys Ala Lys Phe Lys Asn Trp Asp Asp Val Leu Thr Val Asp Tyr Thr
                805                 810                 815     
Arg Asn Ala Glu Ala Val Leu Gln Ser Pro Gly Leu Ser Gly Lys Val
            820                 825                 830         
Lys Arg Asp Ala Glu Lys Lys Asp Gln Met Lys Ala Asp Leu Thr Ala
        835                 840                 845             
Leu Phe Leu Pro Arg Gln Pro Pro Met Ser Leu Ala Glu Ala Glu Gln
    850                 855                 860                 
Leu Met Glu Glu Trp Asn Glu Asp Leu Asp Gly Met Glu Gly Phe Val
865                 870                 875                 880 
Leu Glu Gly Lys Lys Phe Ala Arg Leu Pro Glu Glu Glu Phe Gly His
                885                 890                 895     
Phe Tyr Thr Gln Asp Cys Tyr Val Phe Leu Cys Arg Tyr Trp Val Pro
            900                 905                 910         
Val Glu Tyr Glu Glu Glu Glu Lys Lys Glu Asp Lys Glu Glu Lys Ala
        915                 920                 925             
Glu Gly Lys Glu Gly Glu Glu Ala Thr Ala Glu Ala Glu Glu Lys Gln
    930                 935                 940                 
Pro Glu Glu Asp Phe Gln Cys Ile Val Tyr Phe Trp Gln Gly Arg Glu
945                 950                 955                 960 
Ala Ser Asn Met Gly Trp Leu Thr Phe Thr Phe Ser Leu Gln Lys Lys
                965                 970                 975     
Phe Glu Ser Leu Phe Pro Gly Lys Leu Glu Val Val Arg Met Thr Gln
            980                 985                 990         
Gln Gln Glu Asn Pro Lys Phe Leu Ser His Phe Lys Arg Lys Phe Ile
        995                 1000                1005            
Ile His Arg Gly Lys Arg Lys Ala Val Gln Gly Ala Gln Gln Pro Ser
    1010                1015                1020                
Leu Tyr Gln Ile Arg Thr Asn Gly Ser Ala Leu Cys Thr Arg Cys Ile
1025                1030                1035                1040
Gln Ile Asn Thr Asp Ser Ser Leu Leu Asn Ser Glu Phe Cys Phe Ile
                1045                1050                1055    
Leu Lys Val Pro Phe Glu Ser Glu Asp Asn Gln Gly Ile Val Tyr Ala
            1060                1065                1070        
Trp Val Gly Arg Ala Ser Asp Pro Asp Glu Ala Lys Leu Ala Glu Asp
        1075                1080                1085            
Ile Leu Asn Thr Met Phe Asp Thr Ser Tyr Ser Lys Gln Val Ile Asn
    1090                1095                1100                
Glu Gly Glu Glu Pro Glu Asn Phe Phe Trp Val Gly Ile Gly Ala Gln
1105                1110                1115                1120
Lys Pro Tyr Asp Asp Asp Ala Glu Tyr Met Lys His Thr Arg Leu Phe
                1125                1130                1135    
Arg Cys Ser Asn Glu Lys Gly Tyr Phe Ala Val Thr Glu Lys Cys Ser
            1140                1145                1150        
Asp Phe Cys Gln Asp Asp Leu Ala Asp Asp Asp Ile Met Leu Leu Asp
        1155                1160                1165            
Asn Gly Gln Glu Val Tyr Met Trp Val Gly Thr Gln Thr Ser Gln Val
    1170                1175                1180                
Glu Ile Lys Leu Ser Leu Lys Ala Cys Gln Val Tyr Ile Gln His Met
1185                1190                1195                1200
Arg Ser Lys Glu His Glu Arg Pro Arg Arg Leu Arg Leu Val Arg Lys
                1205                1210                1215    
Gly Asn Glu Gln His Ala Phe Thr Arg Cys Phe His Ala Trp Ser Ala
            1220                1225                1230        
Phe Cys Lys Ala Leu Ala
        1235            


<210> 2451
<211> 87
<212> PRT
<213> Homo sapiens

<400> 2451
Met Glu Ser Ala Ser Glu Ala Ala Lys Lys Tyr Thr Glu Asn Asp Gln
 1               5                  10                  15      
Leu Lys Lys Gly Ala Ala Val Asp Gly Gly Lys Leu Asp Val Gly Asn
            20                  25                  30          
Ala Glu Val Lys Leu Glu Glu Glu Asn Arg Ser Leu Lys Ala Glu Leu
        35                  40                  45              
Gln Lys Leu Lys Asp Glu Leu Ala Ser Thr Lys Gln Lys Leu Glu Lys
    50                  55                  60                  
Ala Glu Asn Gln Val Leu Ala Met Arg Lys Gln Ser Glu Gly Leu Thr
65                  70                  75                  80  
Lys Glu Tyr Asp Arg Leu Gln
                85          


<210> 2452
<211> 837
<212> PRT
<213> Homo sapiens

<400> 2452
Met Ala Ser Val Asn Gly Ser Ser Gln Asn Cys Val Ser Gly Gln Glu
 1               5                  10                  15      
Arg Gly Arg Leu Gly Val Leu Ala Met Ser Cys Ile Asn Glu Leu Met
            20                  25                  30          
Ser Lys Asn Cys Val Pro Met Glu Phe Glu Glu Tyr Leu Leu Arg Met
        35                  40                  45              
Phe Gln Gln Thr Phe Tyr Leu Leu Gln Lys Ile Thr Lys Asp Asn Asn
    50                  55                  60                  
Ala His Thr Val Lys Ser Arg Leu Glu Glu Leu Asp Glu Ser Tyr Ile
65                  70                  75                  80  
Glu Lys Phe Thr Asp Phe Leu Arg Leu Phe Val Ser Val His Leu Arg
                85                  90                  95      
Arg Ile Glu Ser Tyr Ser Gln Phe Pro Val Val Glu Phe Leu Thr Leu
            100                 105                 110         
Leu Phe Lys Tyr Thr Phe His Gln Pro Thr His Glu Gly Tyr Phe Ser
        115                 120                 125             
Cys Leu Asp Ile Trp Thr Leu Phe Leu Asp Tyr Leu Thr Ser Lys Ile
    130                 135                 140                 
Lys Ser Arg Leu Gly Asp Lys Glu Ala Val Leu Asn Arg Tyr Glu Asp
145                 150                 155                 160 
Ala Leu Val Leu Leu Leu Thr Glu Val Leu Asn Arg Ile Gln Phe Arg
                165                 170                 175     
Tyr Asn Gln Ala Gln Leu Glu Glu Leu Asp Asp Glu Thr Leu Asp Asp
            180                 185                 190         
Asp Gln Gln Thr Glu Trp Gln Arg Tyr Leu Arg Gln Ser Leu Glu Val
        195                 200                 205             
Val Ala Lys Val Met Glu Leu Leu Pro Thr His Ala Phe Ser Thr Leu
    210                 215                 220                 
Phe Pro Val Leu Gln Asp Asn Leu Glu Val Tyr Leu Gly Leu Gln Gln
225                 230                 235                 240 
Phe Ile Val Thr Ser Gly Ser Gly His Arg Leu Asn Ile Thr Ala Glu
                245                 250                 255     
Asn Asp Cys Arg Arg Leu His Cys Ser Leu Arg Asp Leu Ser Ser Leu
            260                 265                 270         
Leu Gln Ala Val Gly Arg Leu Ala Glu Tyr Phe Ile Gly Asp Val Phe
        275                 280                 285             
Ala Ala Arg Phe Asn Asp Ala Leu Thr Val Val Glu Arg Leu Val Lys
    290                 295                 300                 
Val Thr Leu Tyr Gly Ser Gln Ile Lys Leu Tyr Asn Ile Glu Thr Ala
305                 310                 315                 320 
Val Pro Ser Val Leu Lys Pro Asp Leu Ile Asp Val His Ala Gln Ser
                325                 330                 335     
Leu Ala Ala Leu Gln Ala Tyr Ser His Trp Leu Ala Gln Tyr Cys Ser
            340                 345                 350         
Glu Val His Arg Gln Asn Thr Gln Gln Phe Val Thr Leu Ile Ser Thr
        355                 360                 365             
Thr Met Asp Ala Ile Thr Pro Leu Ile Ser Thr Lys Val Gln Asp Lys
    370                 375                 380                 
Leu Leu Leu Ser Ala Cys His Leu Leu Val Ser Leu Ala Thr Thr Val
385                 390                 395                 400 
Arg Pro Val Phe Leu Ile Ser Ile Pro Ala Val Gln Lys Val Phe Asn
                405                 410                 415     
Arg Ile Thr Asp Ala Ser Ala Leu Arg Leu Val Asp Lys Ala Gln Val
            420                 425                 430         
Leu Val Cys Arg Ala Leu Ser Asn Ile Leu Leu Leu Pro Trp Pro Asn
        435                 440                 445             
Leu Pro Glu Asn Glu Gln Gln Trp Pro Val Arg Ser Ile Asn His Ala
    450                 455                 460                 
Ser Leu Ile Ser Ala Leu Ser Arg Asp Tyr Arg Asn Leu Lys Pro Ser
465                 470                 475                 480 
Ala Val Ala Pro Gln Arg Lys Met Pro Leu Asp Asp Thr Lys Leu Ile
                485                 490                 495     
Ile His Gln Thr Leu Ser Val Leu Glu Asp Ile Val Glu Asn Ile Ser
            500                 505                 510         
Gly Glu Ser Thr Lys Ser Arg Gln Ile Cys Tyr Gln Ser Leu Gln Glu
        515                 520                 525             
Ser Val Gln Val Ser Leu Ala Leu Phe Pro Ala Phe Ile His Gln Ser
    530                 535                 540                 
Asp Val Thr Asp Glu Met Leu Ser Phe Phe Leu Thr Leu Phe Arg Gly
545                 550                 555                 560 
Leu Arg Val Gln Met Gly Val Pro Phe Thr Glu Gln Ile Ile Gln Thr
                565                 570                 575     
Phe Leu Asn Met Phe Thr Arg Glu Gln Leu Ala Glu Ser Ile Leu His
            580                 585                 590         
Glu Gly Ser Thr Gly Cys Arg Val Val Glu Lys Phe Leu Lys Ile Leu
        595                 600                 605             
Gln Val Val Val Gln Glu Pro Gly Gln Val Phe Lys Pro Phe Leu Pro
    610                 615                 620                 
Ser Ile Ile Ala Leu Cys Met Glu Gln Val Tyr Pro Ile Ile Ala Glu
625                 630                 635                 640 
Arg Pro Ser Pro Asp Val Lys Ala Glu Leu Phe Glu Leu Leu Phe Arg
                645                 650                 655     
Thr Leu His His Asn Trp Arg Tyr Phe Phe Lys Ser Thr Val Leu Ala
            660                 665                 670         
Ser Val Gln Arg Gly Ile Ala Glu Glu Gln Met Glu Asn Glu Pro Gln
        675                 680                 685             
Phe Ser Ala Ile Met Gln Ala Phe Gly Gln Ser Phe Leu Gln Pro Asp
    690                 695                 700                 
Ile His Leu Phe Lys Gln Asn Leu Phe Tyr Leu Glu Thr Leu Asn Thr
705                 710                 715                 720 
Lys Gln Lys Leu Tyr His Lys Lys Ile Phe Arg Thr Ala Met Leu Phe
                725                 730                 735     
Gln Phe Val Asn Val Leu Leu Gln Val Leu Val His Lys Ser His Asp
            740                 745                 750         
Leu Leu Gln Glu Glu Ile Gly Ile Ala Ile Tyr Asn Met Ala Ser Val
        755                 760                 765             
Asp Phe Asp Gly Phe Phe Ala Ala Phe Leu Pro Glu Phe Leu Thr Ser
    770                 775                 780                 
Cys Asp Gly Val Asp Ala Asn Gln Lys Ser Val Leu Gly Arg Asn Phe
785                 790                 795                 800 
Lys Met Asp Arg Asp Leu Pro Ser Phe Thr Gln Asn Val His Arg Leu
                805                 810                 815     
Val Asn Asp Leu Arg Tyr Tyr Arg Leu Cys Asn Asp Ser Leu Pro Pro
            820                 825                 830         
Gly Thr Val Lys Leu
        835         


<210> 2453
<211> 3336
<212> PRT
<213> Homo sapiens

<400> 2453
Met Glu Val Glu Gln Glu Gln Arg Arg Arg Lys Val Glu Ala Gly Arg
 1               5                  10                  15      
Thr Lys Leu Ala His Phe Arg Gln Arg Lys Thr Lys Gly Asp Ser Ser
            20                  25                  30          
His Ser Glu Lys Lys Thr Ala Lys Arg Lys Gly Ser Ala Val Asp Ala
        35                  40                  45              
Ser Val Gln Glu Glu Ser Pro Val Thr Lys Glu Asp Ser Ala Leu Cys
    50                  55                  60                  
Gly Gly Gly Asp Ile Cys Lys Ser Thr Ser Cys Asp Asp Thr Pro Asp
65                  70                  75                  80  
Gly Ala Gly Gly Ala Phe Ala Ala Gln Pro Glu Asp Cys Asp Gly Glu
                85                  90                  95      
Lys Arg Glu Asp Leu Glu Gln Leu Gln Gln Lys Gln Val Asn Asp His
            100                 105                 110         
Pro Pro Glu Gln Cys Gly Met Phe Thr Val Ser Asp His Pro Pro Glu
        115                 120                 125             
Gln His Gly Met Phe Thr Val Gly Asp His Pro Pro Glu Gln Arg Gly
    130                 135                 140                 
Met Phe Thr Val Ser Asp His Pro Pro Glu Gln His Gly Met Phe Thr
145                 150                 155                 160 
Val Ser Asp His Pro Pro Glu Gln Arg Gly Met Phe Thr Ile Ser Asp
                165                 170                 175     
His Gln Pro Glu Gln Arg Gly Met Phe Thr Val Ser Asp His Thr Pro
            180                 185                 190         
Glu Gln Arg Gly Ile Phe Thr Ile Ser Asp His Pro Ala Glu Gln Arg
        195                 200                 205             
Gly Met Phe Thr Lys Glu Cys Glu Gln Glu Cys Glu Leu Ala Ile Thr
    210                 215                 220                 
Asp Leu Glu Ser Gly Arg Glu Asp Glu Ala Gly Leu His Gln Ser Gln
225                 230                 235                 240 
Ala Val His Gly Leu Glu Leu Glu Ala Leu Arg Leu Ser Leu Ser Asn
                245                 250                 255     
Met His Thr Ala Gln Leu Glu Leu Thr Gln Ala Asn Leu Gln Lys Glu
            260                 265                 270         
Lys Glu Thr Ala Leu Thr Glu Leu Arg Glu Met Leu Asn Ser Arg Arg
        275                 280                 285             
Ala Gln Glu Leu Ala Leu Leu Gln Ser Arg Gln Gln His Glu Leu Glu
    290                 295                 300                 
Leu Leu Arg Glu Gln His Ala Arg Glu Lys Glu Glu Val Val Leu Arg
305                 310                 315                 320 
Cys Gly Gln Glu Ala Ala Glu Leu Lys Glu Lys Leu Gln Ser Glu Met
                325                 330                 335     
Glu Lys Asn Ala Gln Ile Val Lys Thr Leu Lys Glu Asp Trp Glu Ser
            340                 345                 350         
Glu Lys Asp Leu Cys Leu Glu Asn Leu Arg Lys Glu Leu Ser Ala Lys
        355                 360                 365             
His Gln Ser Glu Met Glu Asp Leu Gln Asn Gln Phe Gln Lys Glu Leu
    370                 375                 380                 
Ala Glu Gln Arg Ala Glu Leu Glu Lys Ile Phe Gln Asp Lys Asn Gln
385                 390                 395                 400 
Ala Glu Arg Ala Leu Arg Asn Leu Glu Ser His His Gln Ala Ala Ile
                405                 410                 415     
Glu Lys Leu Arg Glu Asp Leu Gln Ser Glu His Gly Arg Cys Leu Glu
            420                 425                 430         
Asp Leu Glu Phe Lys Phe Lys Glu Ser Glu Lys Glu Lys Gln Leu Glu
        435                 440                 445             
Leu Glu Asn Leu Gln Ala Ser Tyr Glu Asp Leu Lys Ala Gln Ser Gln
    450                 455                 460                 
Glu Glu Ile Arg Arg Leu Trp Ser Gln Leu Asp Ser Ala Arg Thr Ser
465                 470                 475                 480 
Arg Gln Glu Leu Ser Glu Leu His Glu Gln Leu Leu Ala Arg Thr Ser
                485                 490                 495     
Arg Val Glu Asp Leu Glu Gln Leu Lys Gln Arg Glu Lys Thr Gln His
            500                 505                 510         
Glu Ser Glu Leu Glu Gln Leu Arg Ile Tyr Phe Glu Lys Lys Leu Arg
        515                 520                 525             
Asp Ala Glu Lys Thr Tyr Gln Glu Asp Leu Thr Leu Leu Gln Gln Arg
    530                 535                 540                 
Leu Gln Gly Ala Arg Glu Asp Ala Leu Leu Asp Ser Val Glu Val Gly
545                 550                 555                 560 
Leu Ser Cys Val Gly Leu Glu Glu Lys Pro Glu Lys Gly Arg Lys Asp
                565                 570                 575     
His Val Asp Glu Leu Glu Pro Glu Arg His Lys Glu Ser Leu Pro Arg
            580                 585                 590         
Phe Gln Ala Glu Leu Glu Glu Ser His Arg His Gln Leu Glu Ala Leu
        595                 600                 605             
Glu Ser Pro Leu Cys Ile Gln His Glu Gly His Val Ser Asp Arg Cys
    610                 615                 620                 
Cys Val Glu Thr Ser Ala Leu Gly His Glu Trp Arg Leu Glu Pro Ser
625                 630                 635                 640 
Glu Gly His Ser Gln Glu Leu Pro Trp Val His Leu Gln Gly Val Gln
                645                 650                 655     
Asp Gly Asp Leu Glu Ala Asp Thr Glu Arg Ala Ala Arg Val Leu Gly
            660                 665                 670         
Leu Glu Thr Glu His Lys Val Gln Leu Ser Leu Leu Gln Thr Glu Leu
        675                 680                 685             
Lys Glu Glu Ile Glu Leu Leu Lys Ile Glu Asn Arg Asn Leu Tyr Gly
    690                 695                 700                 
Lys Leu Gln His Glu Thr Arg Leu Lys Asp Asp Leu Glu Lys Val Lys
705                 710                 715                 720 
His Asn Leu Ile Glu Asp His Gln Lys Glu Leu Asn Asn Ala Lys Gln
                725                 730                 735     
Lys Thr Glu Leu Met Lys Gln Glu Phe Gln Arg Lys Glu Thr Asp Trp
            740                 745                 750         
Lys Val Met Lys Glu Glu Leu Gln Arg Glu Ala Glu Glu Lys Leu Thr
        755                 760                 765             
Leu Met Leu Leu Glu Leu Arg Glu Lys Ala Glu Ser Glu Lys Gln Thr
    770                 775                 780                 
Ile Ile Asn Lys Phe Glu Leu Arg Glu Ala Glu Met Arg Gln Leu Gln
785                 790                 795                 800 
Asp Gln Gln Ala Ala Gln Ile Leu Asp Leu Glu Arg Ser Leu Thr Glu
                805                 810                 815     
Gln Gln Gly Arg Leu Gln Gln Leu Glu Gln Asp Leu Thr Ser Asp Asp
            820                 825                 830         
Ala Leu His Cys Ser Gln Cys Gly Arg Glu Pro Pro Thr Ala Gln Asp
        835                 840                 845             
Gly Glu Leu Ala Ala Leu His Val Lys Glu Asp Cys Ala Leu Gln Leu
    850                 855                 860                 
Met Leu Ala Arg Ser Arg Phe Leu Glu Glu Arg Lys Glu Ile Thr Glu
865                 870                 875                 880 
Lys Phe Ser Ala Glu Gln Asp Ala Phe Leu Gln Glu Ala Gln Glu Gln
                885                 890                 895     
His Ala Arg Glu Leu Gln Leu Leu Gln Glu Arg His Gln Gln Gln Leu
            900                 905                 910         
Leu Ser Val Thr Ala Glu Leu Glu Ala Arg His Gln Ala Ala Leu Gly
        915                 920                 925             
Glu Leu Thr Ala Ser Leu Glu Ser Lys Gln Gly Ala Leu Leu Ala Ala
    930                 935                 940                 
Arg Val Ala Glu Leu Gln Thr Lys His Ala Ala Asp Leu Gly Ala Leu
945                 950                 955                 960 
Glu Thr Arg His Leu Ser Ser Leu Asp Ser Leu Glu Ser Cys Tyr Leu
                965                 970                 975     
Ser Glu Phe Gln Thr Ile Arg Glu Glu His Arg Gln Ala Leu Glu Leu
            980                 985                 990         
Leu Arg Ala Asp Phe Glu Glu Gln Leu Trp Lys Lys Asp Ser Leu His
        995                 1000                1005            
Gln Thr Ile Leu Thr Gln Glu Leu Glu Lys Leu Lys Arg Lys His Glu
    1010                1015                1020                
Gly Glu Leu Gln Ser Val Arg Asp His Leu Arg Thr Glu Val Ser Thr
1025                1030                1035                1040
Glu Leu Ala Gly Thr Val Ala His Glu Leu Gln Gly Val His Gln Gly
                1045                1050                1055    
Glu Phe Gly Ser Glu Lys Lys Thr Ala Leu His Glu Lys Glu Glu Thr
            1060                1065                1070        
Leu Arg Leu Gln Ser Ala Gln Ala Gln Pro Phe His Gln Glu Glu Lys
        1075                1080                1085            
Glu Ser Leu Ser Leu Gln Leu Gln Lys Lys Asn His Gln Val Gln Gln
    1090                1095                1100                
Leu Lys Asp Gln Val Leu Ser Leu Ser His Glu Ile Glu Glu Cys Arg
1105                1110                1115                1120
Ser Glu Leu Glu Val Leu Gln Gln Arg Arg Glu Arg Glu Asn Arg Glu
                1125                1130                1135    
Gly Ala Asn Leu Leu Ser Met Leu Lys Ala Asp Val Asn Leu Ser His
            1140                1145                1150        
Ser Glu Arg Gly Ala Leu Gln Asp Ala Leu Arg Arg Leu Leu Gly Leu
        1155                1160                1165            
Phe Gly Glu Thr Leu Arg Ala Ala Val Thr Leu Arg Ser Arg Ile Gly
    1170                1175                1180                
Glu Arg Val Gly Leu Cys Leu Asp Asp Ala Gly Ala Gly Leu Ala Leu
1185                1190                1195                1200
Ser Thr Ala Pro Ala Leu Glu Glu Thr Trp Ser Asp Val Ala Leu Pro
                1205                1210                1215    
Glu Leu Asp Arg Thr Leu Ser Glu Cys Ala Glu Met Ser Ser Val Ala
            1220                1225                1230        
Glu Ile Ser Ser His Met Arg Glu Ser Phe Leu Met Ser Pro Glu Ser
        1235                1240                1245            
Val Arg Glu Cys Glu Gln Pro Ile Arg Arg Val Phe Gln Ser Leu Ser
    1250                1255                1260                
Leu Ala Val Asp Gly Leu Met Glu Met Ala Leu Asp Ser Ser Arg Gln
1265                1270                1275                1280
Leu Glu Glu Ala Arg Gln Ile His Ser Arg Phe Glu Lys Glu Phe Ser
                1285                1290                1295    
Phe Lys Asn Glu Glu Thr Ala Gln Val Val Arg Lys His Gln Glu Leu
            1300                1305                1310        
Leu Glu Cys Leu Lys Glu Glu Ser Ala Ala Lys Ala Glu Leu Ala Leu
        1315                1320                1325            
Glu Leu His Lys Thr Gln Gly Thr Leu Glu Gly Phe Lys Val Glu Thr
    1330                1335                1340                
Ala Asp Leu Lys Glu Val Leu Ala Gly Lys Glu Asp Ser Glu His Arg
1345                1350                1355                1360
Leu Val Leu Glu Leu Glu Ser Leu Arg Arg Gln Leu Gln Gln Ala Ala
                1365                1370                1375    
Gln Glu Gln Ala Ala Leu Arg Glu Glu Cys Thr Arg Leu Trp Ser Arg
            1380                1385                1390        
Gly Glu Ala Thr Ala Thr Asp Ala Glu Ala Arg Glu Ala Ala Leu Arg
        1395                1400                1405            
Lys Glu Val Glu Asp Leu Thr Lys Glu Gln Ser Glu Thr Arg Lys Gln
    1410                1415                1420                
Ala Glu Lys Asp Arg Ser Ala Leu Leu Ser Gln Met Lys Ile Leu Glu
1425                1430                1435                1440
Ser Glu Leu Glu Glu Gln Leu Ser Gln His Arg Gly Cys Ala Lys Gln
                1445                1450                1455    
Ala Glu Ala Val Thr Ala Leu Glu Gln Gln Val Ala Ser Leu Asp Lys
            1460                1465                1470        
His Leu Arg Asn Gln Arg Gln Phe Met Asp Glu Gln Ala Ala Glu Arg
        1475                1480                1485            
Glu His Glu Arg Glu Glu Phe Gln Gln Glu Ile Gln Arg Leu Glu Gly
    1490                1495                1500                
Gln Leu Arg Gln Ala Ala Lys Pro Gln Pro Trp Gly Pro Arg Asp Ser
1505                1510                1515                1520
Gln Gln Ala Pro Leu Asp Gly Glu Val Glu Leu Leu Gln Gln Lys Leu
                1525                1530                1535    
Arg Glu Lys Leu Asp Glu Phe Asn Glu Leu Ala Ile Gln Lys Glu Ser
            1540                1545                1550        
Ala Asp Arg Gln Val Leu Met Gln Glu Glu Glu Ile Lys Arg Leu Glu
        1555                1560                1565            
Glu Met Asn Ile Asn Ile Arg Lys Lys Val Ala Gln Leu Gln Glu Glu
    1570                1575                1580                
Val Glu Lys Gln Lys Asn Ile Val Lys Gly Leu Glu Gln Asp Lys Glu
1585                1590                1595                1600
Val Leu Lys Lys Gln Gln Met Ser Ser Leu Leu Leu Ala Ser Thr Leu
                1605                1610                1615    
Gln Ser Thr Leu Asp Ala Gly Arg Cys Pro Glu Pro Pro Ser Gly Ser
            1620                1625                1630        
Pro Pro Glu Gly Pro Glu Ile Gln Leu Glu Val Thr Gln Arg Ala Leu
        1635                1640                1645            
Leu Arg Arg Glu Ser Glu Val Leu Asp Leu Lys Glu Gln Leu Glu Lys
    1650                1655                1660                
Met Lys Gly Asp Leu Glu Ser Lys Asn Glu Glu Ile Leu His Leu Asn
1665                1670                1675                1680
Leu Lys Leu Asp Met Gln Asn Ser Gln Thr Ala Val Ser Leu Arg Glu
                1685                1690                1695    
Leu Glu Glu Glu Asn Thr Ser Leu Lys Val Ile Tyr Thr Arg Ser Ser
            1700                1705                1710        
Glu Ile Glu Glu Leu Lys Ala Thr Ile Glu Asn Leu Gln Glu Asn Gln
        1715                1720                1725            
Lys Arg Leu Gln Lys Glu Lys Ala Glu Glu Ile Glu Gln Leu His Glu
    1730                1735                1740                
Val Ile Glu Lys Leu Gln His Glu Leu Ser Leu Met Gly Pro Val Val
1745                1750                1755                1760
His Glu Val Ser Asp Ser Gln Ala Gly Ser Leu Gln Ser Glu Leu Leu
                1765                1770                1775    
Cys Ser Gln Ala Gly Gly Pro Arg Gly Gln Ala Leu Gln Gly Glu Leu
            1780                1785                1790        
Glu Ala Ala Leu Glu Ala Lys Glu Ala Leu Ser Arg Leu Leu Ala Asp
        1795                1800                1805            
Gln Glu Arg Arg His Ser Gln Ala Leu Glu Ala Leu Gln Gln Arg Leu
    1810                1815                1820                
Gln Gly Ala Glu Glu Ala Ala Glu Leu Gln Leu Ala Glu Leu Glu Arg
1825                1830                1835                1840
Asn Val Ala Leu Arg Glu Ala Glu Val Glu Asp Met Ala Ser Arg Ile
                1845                1850                1855    
Gln Glu Phe Glu Ala Ala Leu Lys Ala Lys Glu Ala Thr Ile Ala Glu
            1860                1865                1870        
Arg Asn Leu Glu Ile Asp Ala Leu Asn Gln Arg Lys Ala Ala His Ser
        1875                1880                1885            
Ala Glu Leu Glu Ala Val Leu Leu Ala Leu Ala Arg Ile Arg Arg Ala
    1890                1895                1900                
Leu Glu Gln Gln Pro Leu Ala Ala Gly Ala Ala Pro Pro Glu Leu Gln
1905                1910                1915                1920
Trp Leu Arg Ala Gln Cys Ala Arg Leu Ser Arg Gln Leu Gln Val Leu
                1925                1930                1935    
His Gln Arg Phe Leu Arg Cys Gln Val Glu Leu Asp Arg Arg Gln Ala
            1940                1945                1950        
Arg Arg Ala Thr Ala His Thr Arg Val Pro Gly Ala His Pro Gln Pro
        1955                1960                1965            
Arg Met Asp Gly Gly Ala Lys Ala Gln Val Thr Gly Asp Val Glu Ala
    1970                1975                1980                
Ser His Asp Ala Ala Leu Glu Pro Val Val Pro Asp Pro Gln Gly Asp
1985                1990                1995                2000
Leu Gln Pro Val Leu Val Thr Leu Lys Asp Ala Pro Leu Cys Lys Gln
                2005                2010                2015    
Glu Gly Val Met Ser Val Leu Thr Val Cys Gln Arg Gln Leu Gln Ser
            2020                2025                2030        
Glu Leu Leu Leu Val Lys Asn Glu Met Arg Leu Ser Leu Glu Asp Gly
        2035                2040                2045            
Gly Lys Gly Lys Glu Lys Val Leu Glu Asp Cys Gln Leu Pro Lys Val
    2050                2055                2060                
Asp Leu Val Ala Gln Val Lys Gln Leu Gln Glu Lys Leu Asn Arg Leu
2065                2070                2075                2080
Leu Tyr Ser Met Thr Phe Gln Asn Val Asp Ala Ala Asp Thr Lys Ser
                2085                2090                2095    
Leu Trp Pro Met Ala Ser Ala His Leu Leu Glu Ser Ser Trp Ser Asp
            2100                2105                2110        
Asp Ser Cys Asp Gly Glu Glu Pro Asp Ile Ser Pro His Ile Asp Thr
        2115                2120                2125            
Cys Asp Ala Asn Thr Ala Thr Gly Gly Val Thr Asp Val Ile Lys Asn
    2130                2135                2140                
Gln Ala Ile Asp Ala Cys Asp Ala Asn Thr Thr Pro Gly Gly Val Thr
2145                2150                2155                2160
Asp Val Ile Lys Asn Trp Asp Ser Leu Ile Pro Asp Glu Met Pro Asp
                2165                2170                2175    
Ser Pro Ile Gln Glu Lys Ser Glu Cys Gln Asp Met Ser Leu Ser Ser
            2180                2185                2190        
Pro Thr Ser Val Leu Gly Gly Ser Arg His Gln Ser His Thr Ala Glu
        2195                2200                2205            
Ala Gly Pro Arg Lys Ser Pro Val Gly Met Leu Asp Leu Ser Ser Trp
    2210                2215                2220                
Ser Ser Pro Glu Val Leu Arg Lys Asp Trp Thr Leu Glu Pro Trp Pro
2225                2230                2235                2240
Ser Leu Pro Val Thr Pro His Ser Gly Ala Leu Ser Leu Cys Ser Ala
                2245                2250                2255    
Asp Thr Ser Leu Gly Asp Arg Ala Asp Thr Ser Leu Pro Gln Thr Gln
            2260                2265                2270        
Gly Pro Gly Leu Leu Cys Ser Pro Gly Val Ser Ala Ala Ala Leu Ala
        2275                2280                2285            
Leu Gln Trp Ala Glu Ser Pro Pro Ala Asp Asp His His Val Gln Arg
    2290                2295                2300                
Thr Ala Val Glu Lys Asp Val Glu Asp Phe Ile Thr Thr Ser Phe Asp
2305                2310                2315                2320
Ser Gln Glu Thr Leu Ser Ser Pro Pro Pro Gly Leu Glu Gly Lys Ala
                2325                2330                2335    
Asp Arg Ser Glu Lys Ser Asp Gly Ser Gly Phe Gly Ala Arg Leu Ser
            2340                2345                2350        
Pro Gly Ser Gly Gly Pro Glu Ala Gln Thr Ala Gly Pro Val Thr Pro
        2355                2360                2365            
Ala Ser Ile Ser Gly Arg Phe Gln Pro Leu Pro Glu Ala Met Lys Glu
    2370                2375                2380                
Lys Glu Val Arg Pro Lys His Val Lys Ala Leu Leu Gln Met Val Arg
2385                2390                2395                2400
Asp Glu Ser His Gln Ile Leu Ala Leu Ser Glu Gly Leu Ala Pro Pro
                2405                2410                2415    
Ser Gly Glu Pro His Pro Pro Arg Lys Glu Asp Glu Ile Gln Asp Ile
            2420                2425                2430        
Ser Leu His Gly Gly Lys Thr Gln Glu Val Pro Thr Ala Cys Pro Asp
        2435                2440                2445            
Trp Arg Gly Asp Leu Leu Gln Val Val Gln Glu Ala Phe Glu Lys Glu
    2450                2455                2460                
Gln Glu Met Gln Gly Val Glu Leu Gln Pro Arg Leu Ser Gly Ser Asp
2465                2470                2475                2480
Leu Gly Gly His Ser Ser Leu Leu Glu Arg Leu Glu Lys Ile Ile Arg
                2485                2490                2495    
Glu Gln Gly Asp Leu Gln Glu Lys Ser Leu Glu His Leu Arg Leu Pro
            2500                2505                2510        
Asp Arg Ser Ser Leu Leu Ser Glu Ile Gln Ala Leu Arg Ala Gln Leu
        2515                2520                2525            
Arg Met Thr His Leu Gln Asn Gln Glu Lys Leu Gln His Leu Arg Thr
    2530                2535                2540                
Ala Leu Thr Ser Ala Glu Ala Arg Gly Ser Gln Gln Glu His Gln Leu
2545                2550                2555                2560
Arg Arg Gln Val Glu Leu Leu Ala Tyr Lys Val Glu Gln Glu Lys Cys
                2565                2570                2575    
Ile Ala Gly Asp Leu Gln Lys Thr Leu Ser Glu Glu Gln Glu Lys Ala
            2580                2585                2590        
Asn Ser Val Gln Lys Leu Leu Ala Ala Glu Gln Thr Val Val Arg Asp
        2595                2600                2605            
Leu Lys Ser Asp Leu Cys Glu Ser Arg Gln Lys Ser Glu Gln Leu Ser
    2610                2615                2620                
Arg Ser Leu Cys Glu Val Gln Gln Glu Val Leu Gln Leu Arg Ser Met
2625                2630                2635                2640
Leu Ser Ser Lys Glu Asn Glu Leu Lys Ala Ala Leu Gln Glu Leu Glu
                2645                2650                2655    
Ser Glu Gln Gly Lys Gly Arg Ala Leu Gln Ser Gln Leu Glu Glu Glu
            2660                2665                2670        
Gln Leu Arg His Leu Gln Arg Glu Ser Gln Ser Ala Lys Ala Leu Glu
        2675                2680                2685            
Glu Leu Arg Ala Ser Leu Glu Thr Gln Arg Ala Gln Ser Ser Arg Leu
    2690                2695                2700                
Cys Val Ala Leu Lys His Glu Gln Thr Ala Lys Asp Asn Leu Gln Lys
2705                2710                2715                2720
Glu Leu Arg Ile Glu His Ser Arg Cys Glu Ala Leu Leu Ala Gln Glu
                2725                2730                2735    
Arg Ser Gln Leu Ser Glu Leu Gln Lys Asp Leu Ala Ala Glu Lys Ser
            2740                2745                2750        
Arg Thr Leu Glu Leu Ser Glu Ala Leu Arg His Glu Arg Leu Leu Thr
        2755                2760                2765            
Glu Gln Leu Ser Gln Arg Thr Gln Glu Ala Cys Val His Gln Asp Thr
    2770                2775                2780                
Gln Ala His His Ala Leu Leu Gln Lys Leu Lys Glu Glu Lys Ser Arg
2785                2790                2795                2800
Val Val Asp Leu Gln Ala Met Leu Glu Lys Val Gln Gln Gln Ala Leu
                2805                2810                2815    
His Ser Gln Gln Gln Leu Glu Ala Glu Ala Gln Lys His Cys Glu Ala
            2820                2825                2830        
Leu Arg Arg Glu Lys Glu Val Ser Ala Thr Leu Lys Ser Thr Val Glu
        2835                2840                2845            
Ala Leu His Thr Gln Lys Arg Glu Leu Arg Cys Ser Leu Glu Arg Glu
    2850                2855                2860                
Arg Glu Lys Pro Ala Trp Leu Gln Ala Glu Leu Glu Gln Ser His Pro
2865                2870                2875                2880
Arg Leu Lys Glu Gln Glu Gly Arg Lys Ala Ala Arg Arg Ser Ala Glu
                2885                2890                2895    
Ala Arg Gln Ser Pro Ala Ala Ala Glu Gln Trp Arg Lys Trp Gln Arg
            2900                2905                2910        
Asp Lys Glu Lys Leu Arg Glu Leu Glu Leu Gln Arg Gln Arg Asp Leu
        2915                2920                2925            
His Lys Ile Lys Gln Leu Gln Gln Thr Val Arg Asp Leu Glu Ser Lys
    2930                2935                2940                
Asp Glu Val Pro Gly Ser Arg Leu His Leu Gly Ser Ala Arg Arg Ala
2945                2950                2955                2960
Ala Gly Ser Asp Ala Asp His Leu Arg Glu Gln Gln Arg Glu Leu Glu
                2965                2970                2975    
Ala Met Arg Gln Arg Leu Leu Ser Ala Ala Arg Leu Leu Thr Ser Phe
            2980                2985                2990        
Thr Ser Gln Ala Val Asp Arg Thr Val Asn Asp Trp Thr Ser Ser Asn
        2995                3000                3005            
Glu Lys Ala Val Met Ser Leu Leu His Thr Leu Glu Glu Leu Lys Ser
    3010                3015                3020                
Asp Leu Ser Arg Pro Thr Ser Ser Gln Lys Lys Met Ala Ala Glu Leu
3025                3030                3035                3040
Gln Phe Gln Phe Val Asp Val Leu Leu Lys Asp Asn Val Ser Leu Thr
                3045                3050                3055    
Lys Ala Leu Ser Thr Val Thr Gln Glu Lys Leu Glu Leu Ser Arg Ala
            3060                3065                3070        
Val Ser Lys Leu Glu Lys Leu Leu Lys His His Leu Gln Lys Gly Cys
        3075                3080                3085            
Ser Pro Ser Arg Ser Glu Arg Ser Ala Trp Lys Pro Asp Glu Thr Ala
    3090                3095                3100                
Pro Gln Ser Ser Leu Arg Arg Pro Asp Pro Gly Arg Leu Pro Pro Ala
3105                3110                3115                3120
Ala Ser Glu Glu Ala His Thr Ser Asn Val Lys Met Glu Lys Leu Tyr
                3125                3130                3135    
Leu His Tyr Leu Arg Ala Glu Ser Phe Arg Lys Ala Leu Ile Tyr Gln
            3140                3145                3150        
Lys Lys Tyr Leu Leu Leu Leu Ile Gly Gly Phe Gln Asp Ser Glu Gln
        3155                3160                3165            
Glu Thr Leu Ser Met Ile Ala His Leu Gly Val Phe Pro Ser Lys Ala
    3170                3175                3180                
Glu Arg Lys Ile Thr Ser Arg Pro Phe Thr Arg Phe Arg Thr Ala Val
3185                3190                3195                3200
Arg Val Val Ile Ala Ile Leu Arg Leu Arg Phe Leu Val Lys Lys Trp
                3205                3210                3215    
Gln Glu Val Asp Arg Lys Gly Ala Leu Ala Gln Gly Lys Ala Pro Arg
            3220                3225                3230        
Pro Gly Pro Arg Ala Arg Gln Pro Gln Ser Pro Pro Arg Thr Arg Glu
        3235                3240                3245            
Ser Pro Pro Thr Arg Asp Val Pro Ser Gly His Thr Arg Asp Pro Ala
    3250                3255                3260                
Arg Gly Arg Arg Leu Ala Ala Ala Ala Ser Pro His Ser Gly Gly Arg
3265                3270                3275                3280
Ala Thr Pro Ser Pro Asn Ser Arg Leu Glu Arg Ser Leu Thr Ala Ser
                3285                3290                3295    
Gln Asp Pro Glu His Ser Leu Thr Glu Tyr Ile His His Leu Glu Val
            3300                3305                3310        
Ile Gln Gln Arg Leu Gly Gly Val Leu Pro Asp Ser Thr Ser Lys Lys
        3315                3320                3325            
Ser Cys His Pro Met Ile Lys Gln
    3330                3335    


<210> 2454
<211> 126
<212> PRT
<213> Homo sapiens

<400> 2454
Met Ala Ala Gly Pro Glu Pro Pro Glu Trp Glu Pro Arg Trp Arg Lys
 1               5                  10                  15      
Ala Leu Arg Gly Lys Glu Asn Lys Gly Ser Val Glu Ile Met Arg Lys
            20                  25                  30          
Asp Leu Asn Asp Ala Arg Asp Leu His Gly Gln Ala Glu Ser Ala Ala
        35                  40                  45              
Ala Val Trp Lys Gly His Val Met Asp Arg Arg Lys Lys Ala Leu Thr
    50                  55                  60                  
Asp Tyr Lys Lys Leu Arg Ala Phe Phe Val Glu Glu Glu Glu His Phe
65                  70                  75                  80  
Leu Gln Glu Ala Glu Lys Glu Glu Gly Leu Pro Glu Asp Glu Leu Ala
                85                  90                  95      
Asp Pro Thr Glu Arg Phe Arg Ser Leu Leu Gln Ala Val Ser Glu Leu
            100                 105                 110         
Glu Lys Lys His Arg Asn Leu Gly Leu Ser Met Leu Leu Gln
        115                 120                 125     


<210> 2455
<211> 293
<212> PRT
<213> Homo sapiens

<400> 2455
Met Thr Gly Leu Tyr Glu Leu Val Trp Arg Val Leu His Ala Leu Leu
 1               5                  10                  15      
Cys Leu His Arg Thr Leu Thr Ser Trp Leu Arg Val Arg Phe Gly Thr
            20                  25                  30          
Trp Asn Trp Ile Trp Arg Arg Cys Cys Arg Ala Ala Ser Ala Ala Val
        35                  40                  45              
Leu Ala Pro Leu Gly Phe Thr Leu Arg Lys Pro Pro Ala Val Gly Arg
    50                  55                  60                  
Asn Arg Arg His His Arg His Pro Arg Gly Gly Ser Cys Leu Ala Ala
65                  70                  75                  80  
Ala His His Arg Met Arg Trp Arg Ala Asp Gly Arg Ser Leu Glu Lys
                85                  90                  95      
Leu Pro Val His Met Gly Leu Val Ile Thr Glu Val Glu Gln Glu Pro
            100                 105                 110         
Ser Phe Ser Asp Ile Ala Ser Leu Val Val Trp Cys Met Ala Val Gly
        115                 120                 125             
Ile Ser Tyr Ile Ser Val Tyr Asp His Gln Gly Ile Phe Lys Arg Asn
    130                 135                 140                 
Asn Ser Arg Leu Met Asp Glu Ile Leu Lys Gln Gln Gln Glu Leu Leu
145                 150                 155                 160 
Gly Leu Asp Cys Ser Lys Tyr Ser Pro Glu Phe Ala Asn Ser Asn Asp
                165                 170                 175     
Lys Asp Asp Gln Val Leu Asn Cys His Leu Ala Val Lys Val Leu Ser
            180                 185                 190         
Pro Glu Asp Gly Lys Ala Asp Ile Val Arg Ala Ala Gln Asp Phe Cys
        195                 200                 205             
Gln Leu Val Ala Gln Lys Gln Lys Arg Pro Thr Asp Leu Asp Val Asp
    210                 215                 220                 
Thr Leu Gly Ser Leu Leu Ser Ser Asn Gly Cys Pro Asp Pro Asp Leu
225                 230                 235                 240 
Val Leu Lys Phe Gly Pro Val Asp Ser Thr Leu Gly Phe Leu Pro Trp
                245                 250                 255     
His Ile Arg Leu Thr Glu Ile Val Ser Leu Pro Ser His Leu Asn Ile
            260                 265                 270         
Ser Tyr Glu Asp Phe Phe Ser Ala Leu Arg Gln Tyr Ala Ala Cys Glu
        275                 280                 285             
Gln Arg Leu Gly Lys
    290             


<210> 2456
<211> 527
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114,
115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126,
127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138,
139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149
<223> Xaa = Any Amino Acid

<221> VARIANT        
<222> 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160, 161,
162, 163, 164, 165, 166, 167, 168, 169, 170, 171
<223> Xaa = Any Amino Acid

<400> 2456
Met Glu Asn Gln Glu Lys Ala Ser Ile Ala Gly His Met Phe Asp Val
 1               5                  10                  15      
Val Val Ile Gly Gly Gly Ile Ser Gly Leu Ser Ala Ala Lys Leu Leu
            20                  25                  30          
Thr Glu Tyr Gly Val Ser Val Leu Val Leu Glu Ala Arg Asp Arg Val
        35                  40                  45              
Gly Gly Arg Thr Tyr Thr Ile Arg Asn Glu His Val Asp Tyr Val Asp
    50                  55                  60                  
Val Gly Gly Ala Tyr Val Gly Pro Thr Gln Asn Arg Ile Leu Arg Leu
65                  70                  75                  80  
Ser Lys Glu Leu Gly Ile Glu Thr Tyr Lys Val Asn Val Ser Glu Arg
                85                  90                  95      
Leu Val Gln Tyr Val Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            100                 105                 110         
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
        115                 120                 125             
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    130                 135                 140                 
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
145                 150                 155                 160 
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Phe Ala Tyr Leu
                165                 170                 175     
Phe Val Asn Ile Asn Val Thr Ser Glu Pro His Glu Val Ser Ala Leu
            180                 185                 190         
Trp Phe Leu Trp Tyr Val Lys Gln Cys Gly Gly Thr Thr Arg Ile Phe
        195                 200                 205             
Ser Val Thr Asn Gly Gly Gln Glu Arg Lys Phe Val Gly Gly Ser Gly
    210                 215                 220                 
Gln Val Ser Glu Arg Ile Met Asp Leu Leu Gly Asp Gln Val Lys Leu
225                 230                 235                 240 
Asn His Pro Val Thr His Val Asp Gln Ser Ser Asp Asn Ile Ile Ile
                245                 250                 255     
Glu Thr Leu Asn His Glu His Tyr Glu Cys Lys Tyr Val Ile Asn Ala
            260                 265                 270         
Ile Pro Pro Thr Leu Thr Ala Lys Ile His Phe Arg Pro Glu Leu Pro
        275                 280                 285             
Ala Glu Arg Asn Gln Leu Ile Gln Arg Leu Pro Met Gly Ala Val Ile
    290                 295                 300                 
Lys Cys Met Met Tyr Tyr Lys Glu Ala Phe Trp Lys Lys Lys Asp Tyr
305                 310                 315                 320 
Cys Gly Cys Met Ile Ile Glu Asp Glu Asp Ala Pro Ile Ser Ile Thr
                325                 330                 335     
Leu Asp Asp Thr Lys Pro Asp Gly Ser Leu Pro Ala Ile Met Gly Phe
            340                 345                 350         
Ile Leu Ala Arg Lys Ala Asp Arg Leu Ala Lys Leu His Lys Glu Ile
        355                 360                 365             
Arg Lys Lys Lys Ile Cys Glu Leu Tyr Ala Lys Val Leu Gly Ser Gln
    370                 375                 380                 
Glu Ala Leu His Pro Val His Tyr Glu Glu Lys Asn Trp Cys Glu Glu
385                 390                 395                 400 
Gln Tyr Ser Gly Gly Cys Tyr Thr Ala Tyr Phe Pro Pro Gly Ile Met
                405                 410                 415     
Thr Gln Tyr Gly Arg Val Ile Arg Gln Pro Val Gly Arg Ile Phe Phe
            420                 425                 430         
Ala Gly Thr Glu Thr Ala Thr Lys Trp Ser Gly Tyr Met Glu Gly Ala
        435                 440                 445             
Val Glu Ala Gly Glu Arg Ala Ala Arg Glu Val Leu Asn Gly Leu Gly
    450                 455                 460                 
Lys Val Thr Glu Lys Asp Ile Trp Val Gln Glu Pro Glu Ser Lys Asp
465                 470                 475                 480 
Val Pro Ala Val Glu Ile Thr His Thr Phe Trp Glu Arg Asn Leu Pro
                485                 490                 495     
Ser Val Ser Gly Leu Leu Lys Ile Ile Gly Phe Ser Thr Ser Val Thr
            500                 505                 510         
Ala Leu Gly Phe Val Leu Tyr Lys Tyr Lys Leu Leu Pro Arg Ser
        515                 520                 525         


<210> 2457
<211> 663
<212> PRT
<213> Homo sapiens

<400> 2457
Met Phe Asp Leu Val Asp Tyr Lys Asn Phe Ser Ala Ser Ser Ile Ala
 1               5                  10                  15      
Lys Ile Gly Ser Asp Pro Leu Lys Leu Val Arg Asp Ala Met Glu Glu
            20                  25                  30          
Thr Thr Asp Trp Ile Tyr Gly Phe Phe Ser Leu Leu Ser Asp Ile Ile
        35                  40                  45              
Ser Ser Glu Asp Glu Glu Asp Asp Asp Gly Asp Glu Asp Thr Asp Lys
    50                  55                  60                  
Gly Glu Ile Asp Glu Pro Pro Leu Arg Lys Lys Glu Ile His Lys Asp
65                  70                  75                  80  
Lys Thr Glu Lys Gln Glu Lys Pro Glu Arg Lys Ile Gln Thr Lys Val
                85                  90                  95      
Thr His Lys Glu Lys Glu Lys Gly Lys Glu Lys Val Arg Glu Lys Glu
            100                 105                 110         
Lys Pro Glu Lys Lys Ala Thr His Lys Glu Lys Ile Glu Lys Lys Glu
        115                 120                 125             
Lys Pro Glu Thr Lys Thr Leu Ala Lys Glu Gln Lys Lys Ala Lys Thr
    130                 135                 140                 
Ala Glu Lys Ser Glu Glu Lys Thr Lys Lys Glu Val Lys Gly Gly Lys
145                 150                 155                 160 
Gln Glu Lys Val Lys Gln Thr Ala Ala Lys Val Lys Glu Val Gln Lys
                165                 170                 175     
Thr Pro Ser Lys Pro Lys Glu Lys Glu Asp Lys Glu Lys Ala Ala Val
            180                 185                 190         
Ser Lys His Glu Gln Lys Asp Gln Tyr Ala Phe Cys Arg Tyr Met Ile
        195                 200                 205             
Asp Ile Phe Val His Gly Asp Leu Lys Pro Gly Gln Ser Pro Ala Ile
    210                 215                 220                 
Pro Pro Pro Leu Pro Thr Glu Gln Ala Ser Arg Pro Thr Pro Ala Ser
225                 230                 235                 240 
Pro Ala Leu Glu Glu Lys Glu Gly Glu Lys Lys Lys Ala Glu Lys Lys
                245                 250                 255     
Val Thr Ser Glu Thr Lys Lys Lys Glu Lys Glu Asp Ile Lys Lys Lys
            260                 265                 270         
Ser Glu Lys Glu Thr Ala Ile Asp Val Glu Lys Lys Glu Pro Gly Lys
        275                 280                 285             
Ala Ser Glu Thr Lys Gln Gly Thr Val Lys Ile Ala Ala Gln Ala Ala
    290                 295                 300                 
Ala Lys Lys Asp Glu Lys Lys Glu Asp Ser Lys Lys Thr Lys Lys Pro
305                 310                 315                 320 
Ala Glu Val Glu Gln Pro Lys Gly Lys Lys Gln Glu Lys Lys Glu Lys
                325                 330                 335     
His Val Glu Pro Ala Lys Ser Pro Lys Lys Glu His Ser Val Pro Ser
            340                 345                 350         
Asp Lys Gln Val Lys Ala Lys Thr Glu Arg Ala Lys Glu Glu Ile Gly
        355                 360                 365             
Ala Val Ser Ile Lys Lys Ala Val Pro Gly Lys Lys Glu Glu Lys Thr
    370                 375                 380                 
Thr Lys Thr Val Glu Gln Glu Ile Arg Lys Glu Lys Ser Gly Lys Thr
385                 390                 395                 400 
Ser Ser Ile Leu Lys Asp Lys Glu Pro Ile Lys Gly Lys Glu Glu Lys
                405                 410                 415     
Val Pro Ala Ser Leu Lys Glu Lys Glu Pro Glu Thr Lys Lys Asp Glu
            420                 425                 430         
Lys Met Ser Lys Ala Gly Lys Glu Val Lys Pro Lys Pro Pro Gln Leu
        435                 440                 445             
Gln Gly Lys Lys Glu Glu Lys Pro Glu Pro Gln Ile Lys Lys Glu Ala
    450                 455                 460                 
Lys Pro Ala Ile Ser Glu Lys Val Gln Ile His Lys Gln Asp Ile Val
465                 470                 475                 480 
Lys Pro Glu Lys Thr Val Ser His Gly Lys Pro Glu Glu Lys Val Leu
                485                 490                 495     
Lys Gln Val Lys Ala Val Thr Ile Glu Lys Thr Ala Lys Pro Lys Pro
            500                 505                 510         
Thr Lys Lys Ala Glu His Arg Glu Arg Glu Pro Pro Ser Ile Lys Thr
        515                 520                 525             
Asp Lys Pro Lys Pro Thr Pro Lys Gly Thr Ser Glu Val Thr Glu Ser
    530                 535                 540                 
Gly Lys Lys Lys Thr Glu Ile Ser Glu Lys Glu Ser Lys Glu Lys Ala
545                 550                 555                 560 
Asp Met Lys His Leu Arg Glu Glu Lys Val Ser Thr Arg Lys Glu Ser
                565                 570                 575     
Leu Gln Leu His Asn Val Thr Lys Ala Glu Lys Pro Ala Arg Val Ser
            580                 585                 590         
Lys Asp Val Glu Asp Val Pro Ala Ser Lys Lys Ala Lys Glu Gly Thr
        595                 600                 605             
Glu Asp Val Ser Pro Thr Lys Gln Lys Ser Pro Ile Ser Phe Phe Gln
    610                 615                 620                 
Cys Val Tyr Leu Asp Gly Tyr Asn Gly Tyr Gly Phe Gln Phe Pro Phe
625                 630                 635                 640 
Thr Pro Ala Asp Arg Pro Gly Glu Ser Ser Gly Gln Ala Asn Ser Pro
                645                 650                 655     
Gly Gln Lys Gln Gln Gly Gln
            660             


<210> 2458
<211> 1063
<212> PRT
<213> Homo sapiens

<400> 2458
Met Pro His Leu Pro Leu Ala Ser Phe Arg Pro Pro Phe Trp Gly Leu
 1               5                  10                  15      
Arg His Ser Arg Gly Leu Pro Arg Phe His Ser Val Ser Thr Gln Ser
            20                  25                  30          
Glu Pro His Gly Ser Pro Ile Ser Arg Arg Asn Arg Glu Ala Lys Gln
        35                  40                  45              
Lys Arg Leu Arg Glu Lys Gln Ala Thr Leu Glu Ala Glu Ile Ala Gly
    50                  55                  60                  
Glu Ser Lys Ser Pro Ala Glu Ser Ile Lys Ala Trp Arg Pro Lys Glu
65                  70                  75                  80  
Leu Val Leu Tyr Glu Ile Pro Thr Lys Pro Gly Glu Lys Lys Asp Val
                85                  90                  95      
Ser Gly Pro Leu Pro Pro Ala Tyr Ser Pro Arg Tyr Val Glu Ala Ala
            100                 105                 110         
Trp Tyr Pro Trp Trp Val Arg Glu Gly Phe Phe Lys Pro Glu Tyr Gln
        115                 120                 125             
Ala Arg Leu Pro Gln Ala Thr Gly Glu Thr Phe Ser Met Cys Ile Pro
    130                 135                 140                 
Pro Pro Asn Val Thr Gly Ser Leu His Ile Gly His Ala Leu Thr Val
145                 150                 155                 160 
Ala Ile Gln Asp Ala Leu Val Arg Trp His Arg Met Arg Gly Asp Gln
                165                 170                 175     
Val Leu Trp Val Pro Gly Ser Asp His Ala Gly Ile Ala Thr Gln Ala
            180                 185                 190         
Val Val Glu Lys Gln Leu Trp Lys Glu Arg Gly Val Arg Arg His Glu
        195                 200                 205             
Leu Ser Arg Glu Ala Phe Leu Arg Glu Val Trp Gln Trp Lys Glu Ala
    210                 215                 220                 
Lys Gly Gly Glu Ile Cys Glu Gln Leu Arg Ala Leu Gly Ala Ser Leu
225                 230                 235                 240 
Asp Trp Asp Arg Glu Cys Phe Thr Met Asp Val Gly Ser Ser Val Ala
                245                 250                 255     
Val Thr Glu Ala Phe Val Arg Leu Tyr Lys Ala Gly Leu Leu Tyr Arg
            260                 265                 270         
Asn His Gln Leu Val Asn Trp Ser Cys Ala Leu Arg Ser Ala Ile Ser
        275                 280                 285             
Asp Ile Glu Val Glu Asn Arg Pro Leu Pro Gly His Thr Gln Leu Arg
    290                 295                 300                 
Leu Pro Gly Cys Pro Thr Pro Val Ser Phe Gly Leu Leu Phe Ser Val
305                 310                 315                 320 
Ala Phe Pro Val Asp Gly Glu Pro Asp Ala Glu Val Val Val Gly Thr
                325                 330                 335     
Thr Arg Pro Glu Thr Leu Pro Gly Asp Val Ala Val Ala Val His Pro
            340                 345                 350         
Asp Asp Ser Arg Tyr Thr His Leu His Gly Arg Gln Leu Arg His Pro
        355                 360                 365             
Leu Met Gly Gln Pro Leu Pro Leu Ile Thr Asp Tyr Ala Val Gln Pro
    370                 375                 380                 
His Val Gly Thr Gly Ala Val Lys Val Thr Pro Ala His Ser Pro Ala
385                 390                 395                 400 
Asp Ala Glu Met Gly Ala Arg His Gly Leu Ser Pro Leu Asn Val Ile
                405                 410                 415     
Ala Glu Asp Gly Thr Met Thr Ser Leu Cys Gly Asp Trp Leu Gln Gly
            420                 425                 430         
Leu His Arg Phe Val Ala Arg Glu Lys Ile Met Ser Val Leu Ser Glu
        435                 440                 445             
Trp Gly Leu Phe Arg Gly Leu Gln Asn His Pro Met Val Leu Pro Ile
    450                 455                 460                 
Cys Ser Arg Ser Gly Asp Val Ile Glu Tyr Leu Leu Lys Asn Gln Trp
465                 470                 475                 480 
Phe Val Arg Cys Gln Glu Met Gly Ala Arg Ala Ala Lys Ala Val Glu
                485                 490                 495     
Ser Gly Ala Leu Glu Leu Ser Pro Ser Phe His Gln Lys Asn Trp Gln
            500                 505                 510         
His Trp Phe Ser His Ile Gly Asp Trp Cys Val Ser Arg Gln Leu Trp
        515                 520                 525             
Trp Gly His Gln Ile Pro Ala Tyr Leu Val Val Glu Asp His Ala Gln
    530                 535                 540                 
Gly Glu Glu Asp Cys Trp Val Val Gly Arg Ser Glu Ala Glu Ala Arg
545                 550                 555                 560 
Glu Val Ala Ala Glu Leu Thr Gly Arg Pro Gly Ala Glu Leu Thr Leu
                565                 570                 575     
Glu Arg Asp Pro Asp Val Leu Asp Thr Trp Phe Ser Ser Ala Leu Phe
            580                 585                 590         
Pro Phe Ser Ala Leu Gly Trp Pro Gln Glu Thr Pro Asp Leu Ala Arg
        595                 600                 605             
Phe Tyr Pro Leu Ser Leu Leu Glu Thr Gly Ser Asp Leu Leu Leu Phe
    610                 615                 620                 
Trp Val Gly Arg Met Val Met Leu Gly Thr Gln Leu Thr Gly Gln Leu
625                 630                 635                 640 
Pro Phe Ser Lys Val Leu Leu His Pro Met Val Arg Asp Arg Gln Gly
                645                 650                 655     
Arg Lys Met Ser Lys Ser Leu Gly Asn Val Leu Asp Pro Arg Asp Ile
            660                 665                 670         
Ile Ser Gly Val Glu Met Gln Val Leu Gln Glu Lys Leu Arg Ser Gly
        675                 680                 685             
Asn Leu Asp Pro Ala Glu Leu Ala Ile Val Ala Ala Ala Gln Lys Lys
    690                 695                 700                 
Asp Phe Pro His Gly Ile Pro Glu Cys Gly Thr Asp Ala Leu Arg Phe
705                 710                 715                 720 
Thr Leu Cys Ser His Gly Val Gln Ala Gly Asp Leu His Leu Ser Val
                725                 730                 735     
Ser Glu Val Gln Ser Cys Arg His Phe Cys Asn Lys Ile Trp Asn Ala
            740                 745                 750         
Leu Arg Phe Ile Leu Asn Ala Leu Gly Glu Lys Phe Val Pro Gln Pro
        755                 760                 765             
Ala Glu Glu Leu Ser Pro Ser Ser Pro Met Asp Ala Trp Ile Leu Ser
    770                 775                 780                 
Arg Leu Ala Leu Ala Ala Gln Glu Cys Glu Arg Gly Phe Leu Thr Arg
785                 790                 795                 800 
Glu Leu Ser Leu Val Thr His Ala Leu His His Phe Trp Leu His Asn
                805                 810                 815     
Leu Cys Asp Val Tyr Leu Glu Ala Val Lys Pro Val Leu Trp His Ser
            820                 825                 830         
Pro Arg Pro Leu Gly Pro Pro Gln Val Leu Phe Ser Cys Ala Asp Leu
        835                 840                 845             
Gly Leu Arg Leu Leu Ala Pro Leu Met Pro Phe Leu Ala Glu Glu Leu
    850                 855                 860                 
Trp Gln Arg Leu Pro Pro Arg Pro Gly Cys Pro Pro Ala Pro Ser Ile
865                 870                 875                 880 
Ser Val Ala Pro Tyr Pro Ser Ala Cys Ser Leu Glu His Trp Arg Gln
                885                 890                 895     
Pro Glu Leu Glu Arg Arg Phe Ser Arg Val Gln Glu Val Val Gln Val
            900                 905                 910         
Leu Arg Ala Leu Arg Ala Thr Tyr Gln Leu Thr Lys Ala Arg Pro Arg
        915                 920                 925             
Val Leu Leu Gln Ser Ser Glu Pro Gly Asp Gln Gly Leu Phe Glu Ala
    930                 935                 940                 
Phe Leu Glu Pro Leu Gly Thr Leu Gly Tyr Cys Gly Ala Val Gly Leu
945                 950                 955                 960 
Leu Pro Pro Gly Ala Ala Ala Pro Ser Gly Trp Ala Gln Ala Pro Leu
                965                 970                 975     
Ser Asp Thr Ala Gln Val Tyr Met Glu Leu Gln Gly Leu Val Asp Pro
            980                 985                 990         
Gln Ile Gln Leu Pro Leu Leu Ala Ala Arg Arg Tyr Lys Leu Gln Lys
        995                 1000                1005            
Gln Leu Asp Ser Leu Thr Ala Arg Thr Pro Ser Glu Gly Glu Ala Gly
    1010                1015                1020                
Thr Gln Arg Gln Gln Lys Leu Ser Ser Leu Gln Leu Glu Leu Ser Lys
1025                1030                1035                1040
Leu Asp Lys Ala Ala Ser His Leu Arg Gln Leu Met Asp Glu Pro Pro
                1045                1050                1055    
Ala Pro Gly Ser Pro Glu Leu
            1060            


<210> 2459
<211> 933
<212> PRT
<213> Homo sapiens

<400> 2459
Met Val Pro Pro Leu Ala Ile Met Glu Arg Pro Pro Pro Val Met Val
 1               5                  10                  15      
Asn Gly Arg His Asn Tyr Glu Thr Tyr Leu Glu Tyr Ile Ser Arg Thr
            20                  25                  30          
Ser Gln Ser Val Pro Asp Ile Thr Asp Arg Pro Pro His Ser Leu His
        35                  40                  45              
Ser Met Pro Thr Asp Gly Gln Leu Asp Gly Thr Tyr Pro Pro Pro Val
    50                  55                  60                  
His Asp Asp Asn Val Ser Met Ala Ser Ser Gly Ala Thr Gln Ala Glu
65                  70                  75                  80  
Leu Met Thr Leu Thr Ile Val Lys Gly Ala Gln Gly Phe Gly Phe Thr
                85                  90                  95      
Ile Ala Asp Ser Pro Thr Gly Gln Arg Val Lys Gln Ile Leu Asp Ile
            100                 105                 110         
Gln Gly Cys Pro Gly Leu Cys Glu Gly Asp Leu Ile Val Glu Ile Asn
        115                 120                 125             
Gln Gln Asn Val Gln Asn Leu Ser His Thr Glu Val Val Asp Ile Leu
    130                 135                 140                 
Lys Asp Cys Pro Ile Gly Ser Glu Thr Ser Leu Ile Ile His Arg Gly
145                 150                 155                 160 
Gly Phe Phe Ser Pro Trp Lys Thr Pro Lys Pro Ile Met Asp Arg Trp
                165                 170                 175     
Glu Asn Gln Gly Ser Pro Gln Thr Ser Leu Ser Ala Pro Ala Ile Pro
            180                 185                 190         
Gln Asn Leu Pro Phe Pro Pro Ala Leu His Arg Ser Ser Phe Pro Asp
        195                 200                 205             
Ser Thr Glu Ala Phe Asp Pro Arg Lys Pro Asp Pro Tyr Glu Leu Tyr
    210                 215                 220                 
Glu Lys Ser Arg Ala Ile Tyr Glu Ser Arg Gln Gln Val Pro Pro Arg
225                 230                 235                 240 
Thr Ser Phe Arg Met Asp Ser Ser Gly Pro Asp Tyr Lys Glu Leu Asp
                245                 250                 255     
Val His Leu Arg Arg Met Glu Ser Gly Phe Gly Phe Arg Ile Leu Gly
            260                 265                 270         
Gly Asp Glu Pro Gly Gln Pro Ile Leu Ile Gly Ala Val Ile Ala Met
        275                 280                 285             
Gly Ser Ala Asp Arg Asp Gly Arg Leu His Pro Gly Asp Glu Leu Val
    290                 295                 300                 
Tyr Val Asp Gly Ile Pro Val Ala Gly Lys Thr His Arg Tyr Val Ile
305                 310                 315                 320 
Asp Leu Met His His Ala Ala Arg Asn Gly Gln Val Asn Leu Thr Val
                325                 330                 335     
Arg Arg Lys Val Leu Cys Gly Gly Glu Pro Cys Pro Glu Asn Gly Arg
            340                 345                 350         
Ser Pro Gly Ser Val Ser Thr His His Ser Ser Pro Arg Ser Asp Tyr
        355                 360                 365             
Ala Thr Tyr Thr Asn Ser Asn His Ala Ala Pro Ser Ser Asn Ala Ser
    370                 375                 380                 
Pro Pro Glu Gly Phe Ala Ser His Ser Leu Gln Thr Ser Asp Val Val
385                 390                 395                 400 
Ile His Arg Lys Glu Asn Glu Gly Phe Gly Phe Val Ile Ile Ser Ser
                405                 410                 415     
Leu Asn Arg Pro Glu Ser Gly Ser Thr Ile Thr Val Pro His Lys Ile
            420                 425                 430         
Gly Arg Ile Ile Asp Gly Ser Pro Ala Asp Arg Cys Ala Lys Leu Lys
        435                 440                 445             
Val Gly Asp Arg Ile Leu Ala Val Asn Gly Gln Ser Ile Ile Asn Met
    450                 455                 460                 
Pro His Ala Asp Ile Val Lys Leu Ile Lys Asp Ala Gly Leu Ser Val
465                 470                 475                 480 
Thr Leu Arg Ile Ile Pro Gln Glu Glu Leu Asn Ser Pro Thr Ser Ala
                485                 490                 495     
Pro Ser Ser Glu Lys Gln Ser Pro Met Ala Gln Gln Ser Pro Leu Ala
            500                 505                 510         
Gln Gln Ser Pro Leu Ala Gln Pro Ser Pro Ala Thr Pro Asn Ser Pro
        515                 520                 525             
Ile Ala Gln Pro Ala Pro Pro Gln Pro Leu Gln Leu Gln Gly His Glu
    530                 535                 540                 
Asn Ser Tyr Arg Ser Glu Val Lys Ala Arg Gln Asp Val Lys Pro Asp
545                 550                 555                 560 
Ile Arg Gln Pro Pro Phe Thr Asp Tyr Arg Gln Pro Pro Leu Asp Tyr
                565                 570                 575     
Arg Gln Pro Pro Gly Gly Asp Tyr Gln Gln Pro Pro Pro Leu Asp Tyr
            580                 585                 590         
Arg Gln Pro Pro Leu Leu Asp Tyr Arg Gln His Ser Pro Asp Thr Arg
        595                 600                 605             
Gln Tyr Pro Leu Ser Asp Tyr Arg Gln Pro Gln Asp Phe Asp Tyr Phe
    610                 615                 620                 
Thr Val Asp Met Glu Lys Gly Ala Lys Gly Phe Gly Phe Ser Ile Arg
625                 630                 635                 640 
Gly Gly Arg Glu Tyr Lys Met Asp Leu Tyr Val Leu Arg Leu Ala Glu
                645                 650                 655     
Asp Gly Pro Ala Ile Arg Asn Gly Arg Met Arg Val Gly Asp Gln Ile
            660                 665                 670         
Ile Glu Ile Asn Gly Glu Ser Thr Arg Asp Met Thr His Ala Arg Ala
        675                 680                 685             
Ile Glu Leu Ile Lys Ser Gly Gly Arg Arg Val Arg Leu Leu Leu Lys
    690                 695                 700                 
Arg Gly Thr Gly Gln Val Pro Glu Tyr Asp Glu Pro Ala Pro Trp Ser
705                 710                 715                 720 
Ser Pro Ala Ala Ala Ala Pro Gly Leu Pro Glu Val Gly Val Ser Leu
                725                 730                 735     
Asp Asp Gly Leu Ala Pro Phe Ser Pro Ser His Pro Ala Pro Pro Ser
            740                 745                 750         
Asp Pro Ser His Gln Ile Ser Pro Gly Pro Thr Trp Asp Ile Lys Arg
        755                 760                 765             
Glu His Asp Val Arg Lys Pro Lys Glu Leu Ser Ala Cys Gly Gln Lys
    770                 775                 780                 
Lys Gln Arg Leu Gly Glu Gln Arg Glu Arg Ser Ala Ser Pro Gln Arg
785                 790                 795                 800 
Ala Ala Arg Pro Arg Leu Glu Glu Ala Pro Gly Gly Gln Gly Arg Pro
                805                 810                 815     
Glu Ala Gly Arg Pro Ala Ser Glu Ala Arg Ala Pro Gly Leu Ala Ala
            820                 825                 830         
Ala Asp Ala Ala Asp Ala Ala Arg Ala Gly Gly Lys Glu Ala Pro Arg
        835                 840                 845             
Ala Ala Ala Gly Ser Glu Leu Cys Arg Arg Glu Gly Pro Gly Ala Ala
    850                 855                 860                 
Pro Ala Phe Ala Gly Pro Gly Gly Gly Gly Ser Gly Ala Leu Glu Ala
865                 870                 875                 880 
Glu Gly Arg Ala Gly Ala Arg Ala Gly Pro Arg Pro Gly Pro Arg Pro
                885                 890                 895     
Pro Gly Gly Ala Pro Ala Arg Lys Ala Ala Val Ala Pro Gly Pro Trp
            900                 905                 910         
Lys Val Pro Gly Ser Asp Lys Leu Pro Ser Val Leu Lys Pro Gly Ala
        915                 920                 925             
Ser Ala Ala Ser Arg
    930             


<210> 2460
<211> 273
<212> PRT
<213> Homo sapiens

<400> 2460
Met Asp Pro Gly Lys Asp Lys Glu Gly Val Pro Gln Pro Ser Gly Pro
 1               5                  10                  15      
Pro Ala Arg Lys Lys Phe Val Ile Pro Leu Asp Glu Asp Glu Val Pro
            20                  25                  30          
Pro Gly Val Ala Lys Pro Leu Phe Arg Ser Thr Gln Ser Leu Pro Thr
        35                  40                  45              
Val Asp Thr Ser Ala Gln Ala Ala Pro Gln Thr Tyr Ala Glu Tyr Ala
    50                  55                  60                  
Ile Ser Gln Pro Leu Glu Gly Ala Gly Ala Thr Cys Pro Thr Gly Ser
65                  70                  75                  80  
Glu Pro Leu Ala Gly Glu Thr Pro Asn Gln Ala Leu Lys Pro Gly Ala
                85                  90                  95      
Lys Ser Asn Ser Ile Ile Val Ser Pro Arg Gln Arg Gly Asn Pro Val
            100                 105                 110         
Leu Lys Phe Val Arg Asn Val Pro Trp Glu Phe Gly Asp Val Ile Pro
        115                 120                 125             
Asp Tyr Val Leu Gly Gln Ser Thr Cys Ala Leu Phe Leu Ser Leu Arg
    130                 135                 140                 
Tyr His Asn Leu His Pro Asp Tyr Ile His Gly Arg Leu Gln Ser Leu
145                 150                 155                 160 
Gly Lys Asn Phe Ala Leu Arg Val Leu Leu Val Gln Val Asp Val Lys
                165                 170                 175     
Asp Pro Gln Gln Ala Leu Lys Glu Leu Ala Lys Met Cys Ile Leu Ala
            180                 185                 190         
Asp Cys Thr Leu Ile Leu Ala Trp Ser Pro Glu Glu Ala Gly Arg Tyr
        195                 200                 205             
Leu Glu Thr Tyr Lys Ala Tyr Glu Gln Lys Pro Ala Asp Leu Leu Met
    210                 215                 220                 
Glu Lys Leu Glu Gln Asp Phe Val Ser Arg Ser Leu Glu Gln Leu Ile
225                 230                 235                 240 
Ala Ala Ser Arg Glu Asp Leu Ala Leu Cys Pro Gly Leu Gly Pro Gln
                245                 250                 255     
Lys Ala Arg Arg Leu Phe Asp Val Leu His Glu Pro Phe Leu Lys Val
            260                 265                 270         
Pro
    


<210> 2461
<211> 223
<212> PRT
<213> Homo sapiens

<400> 2461
Met Pro Lys Lys Phe Gln Gly Glu Asn Thr Lys Ser Ala Ala Ala Arg
 1               5                  10                  15      
Ala Arg Arg Ala Glu Ala Lys Ala Ala Ala Asp Ala Lys Lys Gln Lys
            20                  25                  30          
Glu Leu Glu Asp Ala Tyr Trp Lys Asp Asp Asp Lys His Val Met Arg
        35                  40                  45              
Lys Glu Gln Arg Lys Glu Glu Lys Glu Lys Arg Arg Leu Asp Gln Leu
    50                  55                  60                  
Glu Arg Lys Lys Glu Thr Gln Arg Leu Leu Glu Glu Glu Asp Ser Lys
65                  70                  75                  80  
Leu Lys Gly Gly Lys Ala Pro Arg Val Ala Thr Ser Ser Lys Val Thr
                85                  90                  95      
Arg Ala Gln Ile Glu Asp Thr Leu Arg Arg Asp His Gln Leu Arg Glu
            100                 105                 110         
Ala Pro Asp Thr Ala Glu Lys Ala Lys Ser His Leu Glu Val Pro Leu
        115                 120                 125             
Glu Glu Asn Val Asn Arg Arg Val Leu Glu Glu Gly Ser Val Glu Ala
    130                 135                 140                 
Arg Thr Ile Glu Asp Ala Ile Ala Val Leu Ser Val Ala Glu Glu Ala
145                 150                 155                 160 
Ala Asp Arg His Pro Glu Arg Arg Met Arg Ala Ala Phe Thr Ala Phe
                165                 170                 175     
Glu Glu Ala Gln Leu Pro Arg Leu Lys Gln Glu Asn Pro Asn Met Arg
            180                 185                 190         
Leu Ser Gln Leu Lys Gln Leu Leu Lys Lys Glu Trp Leu Arg Ser Pro
        195                 200                 205             
Asp Asn Pro Met Asn Gln Arg Ala Val Pro Phe Asn Ala Pro Lys
    210                 215                 220             


<210> 2462
<211> 2527
<212> PRT
<213> Homo sapiens

<400> 2462
Met Val Gln Ala Leu Thr Glu Leu Leu Arg Arg Ala Gln Ala Pro Gln
 1               5                  10                  15      
Ala Pro Arg Ser Arg Ala Cys Glu Pro Ser Thr Pro Arg Arg Ser Arg
            20                  25                  30          
Gly Arg Pro Pro Gly Arg Pro Ala Gly Pro Cys Arg Arg Lys Gln Gln
        35                  40                  45              
Ala Val Val Val Ala Glu Ala Ala Val Thr Ile Pro Lys Pro Glu Pro
    50                  55                  60                  
Pro Pro Pro Val Val Pro Val Lys His Gln Thr Gly Ser Trp Lys Cys
65                  70                  75                  80  
Lys Glu Gly Pro Gly Pro Gly Pro Gly Thr Pro Arg Arg Gly Gly Gln
                85                  90                  95      
Ser Ser Arg Gly Gly Arg Gly Gly Arg Gly Arg Gly Arg Gly Gly Gly
            100                 105                 110         
Leu Pro Phe Val Ile Lys Phe Val Ser Arg Ala Lys Lys Val Lys Met
        115                 120                 125             
Gly Gln Leu Ser Leu Gly Leu Glu Ser Gly Gln Gly Gln Gly Gln His
    130                 135                 140                 
Glu Glu Ser Trp Gln Asp Val Pro Gln Arg Arg Val Gly Ser Gly Gln
145                 150                 155                 160 
Gly Gly Ser Pro Cys Trp Lys Lys Gln Glu Gln Lys Leu Asp Asp Glu
                165                 170                 175     
Glu Glu Glu Lys Lys Glu Glu Glu Glu Lys Asp Lys Glu Gly Glu Glu
            180                 185                 190         
Lys Glu Glu Arg Ala Val Ala Glu Glu Met Met Pro Ala Ala Glu Lys
        195                 200                 205             
Glu Glu Ala Lys Leu Pro Pro Pro Pro Leu Thr Pro Pro Ala Pro Ser
    210                 215                 220                 
Pro Pro Pro Pro Leu Pro Pro Pro Ser Thr Ser Pro Pro Pro Pro Leu
225                 230                 235                 240 
Cys Pro Pro Pro Pro Pro Pro Val Ser Pro Pro Pro Leu Pro Ser Pro
                245                 250                 255     
Pro Pro Pro Pro Ala Gln Glu Glu Gln Glu Glu Ser Pro Pro Pro Val
            260                 265                 270         
Val Pro Ala Thr Cys Ser Arg Lys Arg Gly Arg Pro Pro Leu Thr Pro
        275                 280                 285             
Ser Gln Arg Ala Glu Arg Glu Ala Ala Arg Ala Gly Pro Glu Gly Thr
    290                 295                 300                 
Ser Pro Pro Thr Pro Thr Pro Ser Thr Ala Thr Gly Gly Pro Pro Glu
305                 310                 315                 320 
Asp Ser Pro Thr Val Ala Pro Lys Ser Thr Thr Phe Leu Lys Asn Ile
                325                 330                 335     
Arg Gln Phe Ile Met Pro Val Val Ser Ala Arg Ser Ser Arg Val Ile
            340                 345                 350         
Lys Thr Pro Arg Arg Phe Met Asp Glu Asp Pro Pro Lys Pro Pro Lys
        355                 360                 365             
Val Glu Val Ser Pro Val Leu Arg Pro Pro Ile Thr Thr Ser Pro Pro
    370                 375                 380                 
Val Pro Gln Glu Pro Ala Pro Val Pro Ser Pro Pro Arg Ala Pro Thr
385                 390                 395                 400 
Pro Pro Ser Thr Pro Val Pro Leu Pro Glu Lys Arg Arg Ser Ile Leu
                405                 410                 415     
Arg Glu Pro Thr Phe Arg Trp Thr Ser Leu Thr Arg Glu Leu Pro Pro
            420                 425                 430         
Pro Pro Pro Ala Pro Pro Pro Pro Pro Ala Pro Ser Pro Pro Pro Ala
        435                 440                 445             
Pro Ala Thr Ser Ser Arg Arg Pro Leu Leu Leu Arg Ala Pro Gln Phe
    450                 455                 460                 
Thr Pro Ser Glu Ala His Leu Lys Ile Tyr Glu Ser Val Leu Thr Pro
465                 470                 475                 480 
Pro Pro Leu Gly Ala Pro Glu Ala Pro Glu Pro Glu Pro Pro Pro Ala
                485                 490                 495     
Asp Asp Ser Pro Ala Glu Pro Glu Pro Arg Ala Val Gly Arg Thr Asn
            500                 505                 510         
His Leu Ser Leu Pro Arg Phe Ala Pro Val Val Thr Thr Pro Val Lys
        515                 520                 525             
Ala Glu Val Ser Pro His Gly Ala Pro Ala Leu Ser Asn Gly Pro Gln
    530                 535                 540                 
Thr Gln Ala Gln Leu Leu Gln Pro Leu Gln Ala Leu Gln Thr Gln Leu
545                 550                 555                 560 
Leu Pro Gln Ala Leu Pro Pro Pro Gln Pro Gln Leu Gln Pro Pro Pro
                565                 570                 575     
Ser Pro Gln Gln Met Pro Pro Leu Glu Lys Ala Arg Ile Ala Gly Val
            580                 585                 590         
Gly Ser Leu Pro Leu Ser Gly Val Glu Glu Lys Met Phe Ser Leu Leu
        595                 600                 605             
Lys Arg Ala Lys Val Gln Leu Phe Lys Ile Asp Gln Gln Gln Gln Gln
    610                 615                 620                 
Lys Val Ala Ala Ser Met Pro Leu Ser Pro Gly Gly Gln Met Glu Glu
625                 630                 635                 640 
Val Ala Gly Ala Val Lys Gln Ile Ser Asp Arg Gly Pro Val Arg Ser
                645                 650                 655     
Glu Asp Glu Ser Val Glu Ala Lys Arg Glu Arg Pro Ser Gly Pro Glu
            660                 665                 670         
Ser Pro Val Gln Gly Pro Arg Ile Lys His Val Cys Arg His Ala Ala
        675                 680                 685             
Val Ala Leu Gly Gln Ala Arg Ala Met Val Pro Glu Asp Val Pro Arg
    690                 695                 700                 
Leu Ser Ala Leu Pro Leu Arg Asp Arg Gln Asp Leu Ala Thr Glu Asp
705                 710                 715                 720 
Thr Ser Ser Ala Ser Glu Thr Glu Ser Val Pro Ser Arg Ser Arg Arg
                725                 730                 735     
Gly Lys Val Glu Ala Ala Gly Pro Gly Gly Glu Ser Glu Pro Thr Gly
            740                 745                 750         
Ser Gly Gly Thr Leu Ala His Thr Pro Arg Arg Ser Leu Pro Ser His
        755                 760                 765             
His Gly Lys Lys Met Arg Met Ala Arg Cys Gly His Cys Arg Gly Cys
    770                 775                 780                 
Leu Arg Val Gln Asp Cys Gly Ser Cys Val Asn Cys Leu Asp Lys Pro
785                 790                 795                 800 
Lys Phe Gly Gly Pro Asn Thr Lys Lys Gln Cys Cys Val Tyr Arg Lys
                805                 810                 815     
Cys Asp Lys Ile Glu Ala Arg Lys Met Glu Arg Leu Ala Lys Lys Gly
            820                 825                 830         
Arg Thr Ile Val Lys Thr Leu Leu Pro Trp Asp Ser Asp Glu Ser Pro
        835                 840                 845             
Glu Ala Ser Pro Gly Pro Pro Gly Pro Arg Arg Gly Ala Gly Ala Gly
    850                 855                 860                 
Gly Pro Arg Glu Glu Val Val Ala His Pro Gly Pro Glu Glu Gln Asp
865                 870                 875                 880 
Ser Leu Leu Gln Arg Lys Ser Ala Arg Arg Cys Val Lys Gln Arg Pro
                885                 890                 895     
Ser Tyr Asp Ile Phe Glu Asp Ser Asp Asp Ser Glu Pro Gly Gly Pro
            900                 905                 910         
Pro Ala Pro Arg Arg Arg Thr Pro Arg Glu Asn Glu Leu Pro Leu Pro
        915                 920                 925             
Glu Pro Glu Glu Gln Ser Arg Pro Arg Lys Pro Thr Leu Gln Pro Val
    930                 935                 940                 
Leu Gln Leu Lys Ala Arg Arg Arg Leu Asp Lys Asp Ala Leu Ala Pro
945                 950                 955                 960 
Gly Pro Phe Ala Ser Phe Pro Asn Gly Trp Thr Gly Lys Gln Lys Ser
                965                 970                 975     
Pro Asp Gly Val His Arg Val Arg Val Asp Phe Lys Glu Asp Cys Asp
            980                 985                 990         
Leu Glu Asn Val Trp Leu Met Gly Gly Leu Ser Val Leu Thr Ser Val
        995                 1000                1005            
Pro Gly Gly Pro Pro Met Val Cys Leu Leu Cys Ala Ser Lys Gly Leu
    1010                1015                1020                
His Glu Leu Val Phe Cys Gln Val Cys Cys Asp Pro Phe His Pro Phe
1025                1030                1035                1040
Cys Leu Glu Glu Ala Glu Arg Pro Leu Pro Gln His His Asp Thr Trp
                1045                1050                1055    
Cys Cys Arg Arg Cys Lys Phe Cys His Val Cys Gly Arg Lys Gly Arg
            1060                1065                1070        
Gly Ser Lys His Leu Leu Glu Cys Glu Arg Cys Arg His Ala Tyr His
        1075                1080                1085            
Pro Ala Cys Leu Gly Pro Ser Tyr Pro Thr Arg Ala Thr Arg Lys Arg
    1090                1095                1100                
Arg His Trp Ile Cys Ser Ala Cys Val Arg Cys Lys Ser Cys Gly Ala
1105                1110                1115                1120
Thr Pro Gly Lys Asn Trp Asp Val Glu Trp Ser Gly Asp Tyr Ser Leu
                1125                1130                1135    
Cys Pro Arg Cys Thr Gln Leu Tyr Glu Lys Gly Asn Tyr Cys Pro Ile
            1140                1145                1150        
Cys Thr Arg Cys Tyr Glu Asp Asn Asp Tyr Glu Ser Lys Met Met Gln
        1155                1160                1165            
Cys Ala Gln Cys Asp His Trp Val His Ala Lys Cys Glu Gly Leu Ser
    1170                1175                1180                
Asp Glu Asp Tyr Glu Ile Leu Ser Gly Leu Pro Asp Ser Val Leu Tyr
1185                1190                1195                1200
Thr Cys Gly Pro Cys Ala Gly Ala Ala Gln Pro Arg Trp Arg Glu Ala
                1205                1210                1215    
Leu Ser Gly Ala Leu Gln Gly Gly Leu Arg Gln Val Leu Gln Gly Leu
            1220                1225                1230        
Leu Ser Ser Lys Val Val Gly Pro Leu Leu Leu Cys Thr Gln Cys Gly
        1235                1240                1245            
Pro Asp Gly Lys Gln Leu His Pro Gly Pro Cys Gly Leu Gln Ala Val
    1250                1255                1260                
Ser Gln Arg Phe Glu Asp Gly His Tyr Lys Ser Val His Ser Phe Met
1265                1270                1275                1280
Glu Asp Met Val Gly Ile Leu Met Arg His Ser Glu Glu Gly Glu Thr
                1285                1290                1295    
Pro Asp Arg Arg Ala Gly Gly Gln Met Lys Gly Leu Leu Leu Lys Leu
            1300                1305                1310        
Leu Glu Ser Ala Phe Gly Trp Phe Asp Ala His Asp Pro Lys Tyr Trp
        1315                1320                1325            
Arg Arg Ser Thr Arg Leu Pro Asn Gly Val Leu Pro Asn Ala Val Leu
    1330                1335                1340                
Pro Pro Ser Leu Asp His Val Tyr Ala Gln Trp Arg Gln Gln Glu Pro
1345                1350                1355                1360
Glu Thr Pro Glu Ser Gly Gln Pro Pro Gly Asp Pro Ser Ala Ala Phe
                1365                1370                1375    
Gln Gly Lys Asp Pro Ala Ala Phe Ser His Leu Glu Asp Pro Arg Gln
            1380                1385                1390        
Cys Ala Leu Cys Leu Lys Tyr Gly Asp Ala Asp Ser Lys Glu Ala Gly
        1395                1400                1405            
Arg Leu Leu Tyr Ile Gly Gln Asn Glu Trp Thr His Val Asn Cys Ala
    1410                1415                1420                
Ile Trp Ser Ala Glu Val Phe Glu Glu Asn Asp Gly Ser Leu Lys Asn
1425                1430                1435                1440
Val His Ala Ala Val Ala Arg Gly Arg Gln Met Arg Cys Glu Leu Cys
                1445                1450                1455    
Leu Lys Pro Gly Ala Thr Val Gly Cys Cys Leu Ser Ser Cys Leu Ser
            1460                1465                1470        
Asn Phe His Phe Met Cys Ala Arg Ala Ser Tyr Cys Ile Phe Gln Asp
        1475                1480                1485            
Asp Lys Lys Val Phe Cys Gln Lys His Thr Asp Leu Leu Asp Gly Lys
    1490                1495                1500                
Glu Ile Val Asn Pro Asp Gly Phe Asp Val Leu Arg Arg Val Tyr Val
1505                1510                1515                1520
Asp Phe Glu Gly Ile Asn Phe Lys Arg Lys Phe Leu Thr Gly Leu Glu
                1525                1530                1535    
Pro Asp Ala Ile Asn Val Leu Ile Gly Ser Ile Arg Ile Asp Ser Leu
            1540                1545                1550        
Gly Thr Leu Ser Asp Leu Ser Asp Cys Glu Gly Arg Leu Phe Pro Ile
        1555                1560                1565            
Gly Tyr Gln Cys Ser Arg Leu Tyr Trp Ser Thr Val Asp Ala Arg Arg
    1570                1575                1580                
Arg Cys Trp Tyr Arg Cys Arg Ile Leu Glu Tyr Arg Pro Trp Gly Pro
1585                1590                1595                1600
Arg Glu Glu Pro Ala His Leu Glu Ala Ala Glu Glu Asn Gln Thr Ile
                1605                1610                1615    
Val His Ser Pro Ala Pro Ser Ser Glu Pro Pro Gly Gly Glu Asp Pro
            1620                1625                1630        
Pro Leu Asp Thr Asp Val Leu Val Pro Gly Ala Pro Glu Arg His Ser
        1635                1640                1645            
Pro Ile Gln Asn Leu Asp Pro Pro Leu Arg Pro Asp Ser Gly Ser Ala
    1650                1655                1660                
Pro Pro Pro Ala Pro Arg Ser Phe Ser Gly Ala Arg Ile Lys Val Pro
1665                1670                1675                1680
Asn Tyr Ser Pro Ser Arg Arg Pro Leu Gly Gly Val Ser Phe Gly Pro
                1685                1690                1695    
Leu Pro Ser Pro Gly Ser Pro Ser Ser Leu Thr His His Ile Pro Thr
            1700                1705                1710        
Val Gly Asp Pro Asp Phe Pro Ala Pro Pro Arg Arg Ser Arg Arg Pro
        1715                1720                1725            
Ser Pro Leu Ala Pro Arg Pro Pro Pro Ser Arg Trp Ala Ser Pro Pro
    1730                1735                1740                
Leu Lys Thr Ser Pro Gln Leu Arg Val Pro Pro Pro Thr Ser Val Val
1745                1750                1755                1760
Thr Ala Leu Thr Pro Thr Ser Gly Glu Leu Ala Pro Pro Gly Pro Ala
                1765                1770                1775    
Pro Ser Pro Pro Pro Pro Glu Asp Leu Gly Pro Asp Phe Glu Asp Met
            1780                1785                1790        
Glu Val Val Ser Gly Leu Ser Ala Ala Asp Leu Asp Phe Ala Ala Ser
        1795                1800                1805            
Leu Leu Gly Thr Glu Pro Phe Gln Glu Glu Ile Val Ala Ala Gly Ala
    1810                1815                1820                
Met Gly Ser Ser His Gly Gly Pro Gly Asp Ser Ser Glu Glu Glu Ser
1825                1830                1835                1840
Ser Pro Thr Ser Arg Tyr Ile His Phe Pro Val Thr Val Val Ser Ala
                1845                1850                1855    
Pro Gly Leu Ala Pro Ser Ala Thr Pro Gly Ala Pro Arg Ile Glu Gln
            1860                1865                1870        
Leu Asp Gly Val Asp Asp Gly Thr Asp Ser Glu Ala Glu Ala Val Gln
        1875                1880                1885            
Gln Pro Arg Gly Gln Gly Thr Pro Pro Ser Gly Pro Gly Val Val Arg
    1890                1895                1900                
Ala Gly Val Leu Gly Ala Ala Gly Asp Arg Ala Arg Pro Pro Glu Asp
1905                1910                1915                1920
Leu Pro Ser Glu Ile Val Asp Phe Val Leu Lys Asn Leu Gly Gly Pro
                1925                1930                1935    
Gly Asp Gly Gly Ala Gly Pro Arg Glu Glu Ser Leu Pro Pro Ala Pro
            1940                1945                1950        
Pro Leu Ala Asn Gly Ser Gln Pro Ser Gln Gly Leu Thr Ala Ser Pro
        1955                1960                1965            
Ala Asp Pro Thr Arg Thr Phe Ala Trp Leu Pro Gly Ala Pro Gly Val
    1970                1975                1980                
Arg Val Leu Ser Leu Gly Pro Ala Pro Glu Pro Pro Lys Pro Ala Thr
1985                1990                1995                2000
Ser Lys Ile Ile Leu Val Asn Lys Leu Gly Gln Val Phe Val Lys Met
                2005                2010                2015    
Ala Gly Glu Gly Glu Pro Val Pro Pro Pro Val Lys Gln Pro Pro Leu
            2020                2025                2030        
Pro Pro Thr Ile Ser Pro Thr Ala Pro Thr Ser Trp Thr Leu Pro Pro
        2035                2040                2045            
Gly Pro Leu Leu Gly Val Leu Pro Val Val Gly Val Val Arg Pro Ala
    2050                2055                2060                
Pro Pro Pro Pro Pro Pro Pro Leu Thr Leu Val Leu Ser Ser Gly Pro
2065                2070                2075                2080
Ala Ser Pro Pro Arg Gln Ala Ile Arg Val Lys Arg Val Ser Thr Phe
                2085                2090                2095    
Ser Gly Arg Ser Pro Pro Ala Pro Pro Pro Tyr Lys Ala Pro Arg Leu
            2100                2105                2110        
Asp Glu Asp Gly Glu Ala Ser Glu Asp Thr Pro Gln Val Pro Gly Leu
        2115                2120                2125            
Gly Ser Gly Gly Phe Ser Arg Val Arg Met Lys Thr Pro Thr Val Arg
    2130                2135                2140                
Gly Val Leu Asp Leu Asp Arg Pro Gly Glu Pro Ala Gly Glu Glu Ser
2145                2150                2155                2160
Pro Gly Pro Leu Gln Glu Arg Ser Pro Leu Leu Pro Leu Pro Glu Asp
                2165                2170                2175    
Gly Pro Pro Gln Val Pro Asp Gly Pro Pro Asp Leu Leu Leu Glu Ser
            2180                2185                2190        
Gln Trp His His Tyr Ser Gly Glu Ala Ser Ser Ser Glu Glu Glu Pro
        2195                2200                2205            
Pro Ser Pro Asp Asp Lys Glu Asn Gln Ala Pro Lys Arg Thr Gly Pro
    2210                2215                2220                
His Leu Arg Phe Glu Ile Ser Ser Glu Asp Gly Phe Ser Val Glu Ala
2225                2230                2235                2240
Glu Ser Leu Glu Gly Ala Trp Arg Thr Leu Ile Glu Lys Val Gln Glu
                2245                2250                2255    
Ala Arg Gly His Ala Arg Leu Arg His Leu Ser Phe Ser Gly Met Ser
            2260                2265                2270        
Gly Ala Arg Leu Leu Gly Ile His His Asp Ala Val Ile Phe Leu Ala
        2275                2280                2285            
Glu Gln Leu Pro Gly Ala Gln Arg Cys Gln His Tyr Lys Phe Arg Tyr
    2290                2295                2300                
His Gln Gln Gly Glu Gly Gln Glu Glu Pro Pro Leu Asn Pro His Gly
2305                2310                2315                2320
Ala Ala Arg Ala Glu Val Tyr Leu Arg Lys Cys Thr Phe Asp Met Phe
                2325                2330                2335    
Asn Phe Leu Ala Ser Gln His Arg Val Leu Pro Glu Gly Ala Thr Cys
            2340                2345                2350        
Asp Glu Glu Glu Asp Glu Val Gln Leu Arg Ser Thr Arg Arg Ala Thr
        2355                2360                2365            
Ser Leu Glu Leu Pro Met Ala Met Arg Phe Arg His Leu Lys Lys Thr
    2370                2375                2380                
Ser Lys Glu Ala Val Gly Val Tyr Arg Ser Ala Ile His Gly Arg Gly
2385                2390                2395                2400
Leu Phe Cys Lys Arg Asn Ile Asp Ala Gly Glu Met Val Ile Glu Tyr
                2405                2410                2415    
Ser Gly Ile Val Ile Arg Ser Val Leu Thr Asp Lys Arg Glu Lys Phe
            2420                2425                2430        
Tyr Asp Gly Lys Gly Ile Gly Cys Tyr Met Phe Arg Met Asp Asp Phe
        2435                2440                2445            
Asp Val Val Asp Ala Thr Met His Gly Asn Ala Ala Arg Phe Ile Asn
    2450                2455                2460                
His Ser Cys Glu Pro Asn Cys Phe Ser Arg Val Ile His Val Glu Gly
2465                2470                2475                2480
Gln Lys His Ile Val Ile Phe Ala Leu Arg Arg Ile Leu Arg Gly Glu
                2485                2490                2495    
Glu Leu Thr Tyr Asp Tyr Lys Phe Pro Ile Glu Asp Ala Ser Asn Lys
            2500                2505                2510        
Leu Pro Cys Asn Cys Gly Ala Lys Arg Cys Arg Arg Phe Leu Asn
        2515                2520                2525        


<210> 2463
<211> 740
<212> PRT
<213> Homo sapiens

<400> 2463
Met Asn Glu His Leu Ser Ser Leu Ile Lys Lys Lys Arg Lys Cys Met
 1               5                  10                  15      
Gln Pro Lys Asp Phe Asn Phe Lys Thr Pro Glu Asn Asp Lys Arg Phe
            20                  25                  30          
Gln Lys Lys Phe Glu Lys Met Ala Lys Glu Leu Gln Arg Gln Lys Thr
        35                  40                  45              
Asn Leu Asp Asp Asp Val Pro Ile Leu Leu Phe Glu Ser Asn Gly Ser
    50                  55                  60                  
Leu Ile Tyr Thr Pro Thr Ile Glu Ile Asn Ser Ser His His Ser Ala
65                  70                  75                  80  
Met Glu Lys Arg Leu Gln Glu Met Lys Glu Lys Arg Glu Asn Leu Ser
                85                  90                  95      
Pro Thr Ser Ser Gln Met Ile Gln Gln Ser His Asp Asn Pro Ser Asn
            100                 105                 110         
Ser Leu Cys Glu Thr Pro Leu Asn Ile Ser Arg Asp Thr Leu Cys Ser
        115                 120                 125             
Asp Glu Tyr Phe Ala Gly Gly Leu His Ser Ser Phe Asp Asp Leu Cys
    130                 135                 140                 
Gly Asn Ser Gly Cys Gly Asn Gln Glu Arg Lys Leu Glu Gly Ser Ile
145                 150                 155                 160 
Asn Asp Ile Lys Ser Asp Val Cys Ile Ser Ser Leu Val Leu Lys Ala
                165                 170                 175     
Asn Asn Ile His Ser Ser Pro Ser Phe Thr His Leu Asp Lys Ser Ser
            180                 185                 190         
Pro Gln Lys Phe Leu Ser Asn Leu Ser Lys Glu Glu Ile Asn Leu Gln
        195                 200                 205             
Arg Asn Ile Ala Gly Lys Val Val Thr Pro Asp Gln Lys Gln Ala Ala
    210                 215                 220                 
Gly Met Ser Gln Glu Thr Phe Glu Glu Lys Tyr Arg Leu Ser Pro Thr
225                 230                 235                 240 
Leu Ser Ser Thr Lys Gly His Leu Leu Ile His Ser Arg Pro Arg Ser
                245                 250                 255     
Ser Ser Val Lys Arg Lys Arg Val Ser His Gly Ser His Ser Pro Pro
            260                 265                 270         
Lys Glu Lys Cys Lys Arg Lys Arg Ser Thr Arg Arg Ser Ile Met Pro
        275                 280                 285             
Arg Leu Gln Leu Cys Arg Ser Glu Gly Arg Leu Gln His Val Ala Gly
    290                 295                 300                 
Pro Ala Leu Glu Ala Leu Ser Cys Gly Glu Ser Ser Tyr Asp Asp Tyr
305                 310                 315                 320 
Phe Ser Pro Asp Asn Leu Lys Glu Arg Tyr Ser Glu Asn Leu Pro Pro
                325                 330                 335     
Glu Ser Gln Leu Pro Ser Ser Pro Ala Gln Leu Ser Cys Arg Ser Leu
            340                 345                 350         
Ser Lys Lys Glu Arg Thr Ser Ile Phe Glu Met Ser Asp Phe Ser Cys
        355                 360                 365             
Val Gly Lys Lys Thr Arg Thr Val Asp Ile Thr Asn Phe Thr Ala Lys
    370                 375                 380                 
Thr Ile Ser Ser Pro Arg Lys Thr Gly Asn Gly Glu Gly Arg Ala Thr
385                 390                 395                 400 
Ser Ser Cys Val Thr Ser Ala Pro Glu Glu Ala Leu Arg Cys Cys Arg
                405                 410                 415     
Gln Ala Gly Lys Glu Asp Ala Cys Pro Glu Gly Asn Gly Phe Ser Tyr
            420                 425                 430         
Thr Ile Glu Asp Pro Ala Leu Pro Lys Gly His Asp Asp Asp Leu Thr
        435                 440                 445             
Pro Leu Glu Gly Ser Leu Glu Glu Met Lys Glu Ala Val Gly Leu Lys
    450                 455                 460                 
Ser Thr Gln Asn Lys Gly Thr Thr Ser Lys Ile Ser Asn Ser Ser Glu
465                 470                 475                 480 
Gly Glu Ala Gln Ser Glu His Glu Pro Cys Phe Ile Val Asp Cys Asn
                485                 490                 495     
Met Glu Thr Ser Thr Glu Glu Lys Glu Asn Leu Pro Gly Gly Tyr Ser
            500                 505                 510         
Gly Ser Val Lys Asn Arg Pro Thr Arg His Asp Val Leu Asp Asp Ser
        515                 520                 525             
Cys Asp Gly Phe Lys Asp Leu Ile Lys Pro His Glu Glu Leu Lys Lys
    530                 535                 540                 
Ser Gly Arg Gly Lys Lys Pro Thr Arg Thr Leu Val Met Thr Ser Met
545                 550                 555                 560 
Pro Ser Glu Lys Gln Asn Val Val Ile Gln Val Val Asp Lys Leu Lys
                565                 570                 575     
Gly Phe Ser Ile Ala Pro Asp Val Cys Glu Thr Thr Thr His Val Leu
            580                 585                 590         
Ser Gly Lys Pro Leu Arg Thr Leu Asn Val Leu Leu Gly Ile Ala Arg
        595                 600                 605             
Gly Cys Trp Val Leu Ser Tyr Asp Trp Val Leu Trp Ser Leu Glu Leu
    610                 615                 620                 
Gly His Trp Ile Ser Glu Glu Pro Phe Glu Leu Ser His His Phe Pro
625                 630                 635                 640 
Ala Ala Pro Leu Cys Arg Ser Glu Cys His Leu Ser Ala Gly Pro Tyr
                645                 650                 655     
Arg Gly Thr Leu Phe Ala Asp Gln Pro Ala Met Phe Val Ser Pro Ala
            660                 665                 670         
Ser Ser Pro Pro Val Ala Lys Leu Cys Glu Leu Val His Leu Cys Gly
        675                 680                 685             
Gly Arg Val Ser Gln Val Pro Arg Gln Ala Ser Ile Val Ile Gly Pro
    690                 695                 700                 
Tyr Ser Gly Lys Lys Lys Ala Thr Val Lys Tyr Leu Ser Glu Lys Trp
705                 710                 715                 720 
Val Leu Asp Ser Ile Thr Gln His Lys Val Cys Ala Pro Glu Asn Tyr
                725                 730                 735     
Leu Leu Ser Gln
            740 


<210> 2464
<211> 491
<212> PRT
<213> Homo sapiens

<400> 2464
Met Val Val Phe Leu Ser Cys Gln Leu Phe His Lys Glu Val Leu Arg
 1               5                  10                  15      
Gln Ser Ile Ser His Lys Tyr Leu Met Arg Gly Pro Cys Leu Pro Tyr
            20                  25                  30          
Thr Ser Lys Leu Val Lys Thr Leu Leu Tyr Asn Phe Ile Arg Gln Glu
        35                  40                  45              
Lys Pro Pro Pro Pro Gly Ala His Val Phe Pro Gln Gln Ser Asp Gly
    50                  55                  60                  
Gly Gly Leu Leu Tyr Gly Leu Ala Ser Gly Val Ala Thr Gly Leu Trp
65                  70                  75                  80  
Thr Val Phe Thr Leu Gly Gly Val Gly Ser Lys Ala Ala Ala Ser Pro
                85                  90                  95      
Glu Leu Ser Ser Pro Leu Ala Asn Gln Ser Leu Leu Leu Leu Leu Val
            100                 105                 110         
Leu Ala Asn Leu Thr Asp Ala Ser Asp Ala Pro Asn Pro Tyr Arg Gln
        115                 120                 125             
Ala Ile Met Ser Phe Lys Asn Thr Gln Asp Ser Ser Pro Phe Pro Ser
    130                 135                 140                 
Ser Ile Pro His Ala Phe Gln Ile Asn Phe Asn Ser Leu Tyr Thr Ala
145                 150                 155                 160 
Leu Cys Glu Gln Gln Thr Ser Asp Gln Ala Thr Leu Leu Leu Tyr Thr
                165                 170                 175     
Leu Leu His Gln Asn Ser Asn Ile Arg Thr Tyr Met Leu Ala Arg Thr
            180                 185                 190         
Asp Met Glu Asn Leu Val Leu Pro Ile Leu Glu Ile Leu Tyr His Val
        195                 200                 205             
Glu Glu Arg Asn Ser His His Val Tyr Met Ala Leu Ile Ile Leu Leu
    210                 215                 220                 
Ile Leu Thr Glu Asp Asp Gly Phe Asn Arg Ser Ile His Glu Val Ile
225                 230                 235                 240 
Leu Lys Asn Ile Thr Trp Tyr Ser Glu Arg Val Leu Thr Glu Ile Ser
                245                 250                 255     
Leu Gly Ser Leu Leu Ile Leu Val Val Ile Arg Thr Ile Gln Tyr Asn
            260                 265                 270         
Met Thr Arg Thr Arg Asp Lys Tyr Leu His Thr Asn Cys Leu Ala Ala
        275                 280                 285             
Leu Ala Asn Met Ser Ala Gln Phe Arg Ser Leu His Gln Tyr Ala Ala
    290                 295                 300                 
Gln Arg Ile Ile Ser Leu Phe Ser Leu Leu Ser Lys Lys His Asn Lys
305                 310                 315                 320 
Val Leu Glu Gln Ala Thr Gln Ser Leu Arg Gly Ser Leu Ser Ser Asn
                325                 330                 335     
Asp Val Pro Leu Pro Asp Tyr Ala Gln Asp Leu Asn Val Ile Glu Glu
            340                 345                 350         
Val Ile Arg Met Met Leu Glu Ile Ile Asn Ser Cys Leu Thr Asn Ser
        355                 360                 365             
Leu His His Asn Pro Asn Leu Val Tyr Ala Leu Leu Tyr Lys Arg Asp
    370                 375                 380                 
Leu Phe Glu Gln Phe Arg Thr His Pro Ser Phe Gln Asp Ile Met Gln
385                 390                 395                 400 
Asn Ile Asp Leu Val Ile Ser Phe Phe Ser Ser Arg Leu Leu Gln Ala
                405                 410                 415     
Gly Ala Glu Leu Ser Val Glu Arg Val Leu Glu Ile Ile Lys Gln Gly
            420                 425                 430         
Val Val Ala Leu Pro Lys Asp Arg Leu Lys Lys Phe Pro Glu Leu Lys
        435                 440                 445             
Phe Lys Tyr Val Glu Glu Glu Gln Pro Glu Glu Phe Phe Ile Pro Tyr
    450                 455                 460                 
Val Trp Ser Leu Val Tyr Asn Ser Ala Val Gly Leu Tyr Trp Asn Pro
465                 470                 475                 480 
Gln Asp Ile Gln Leu Phe Thr Met Asp Ser Asp
                485                 490     


<210> 2465
<211> 311
<212> PRT
<213> Homo sapiens

<400> 2465
Met Ala Gln Pro Pro Val His Asp Tyr Val Pro Val Ser Trp Thr Ala
 1               5                  10                  15      
Leu Val His Val Lys Ala Glu Tyr Phe Arg Ser Leu Ala His Tyr His
            20                  25                  30          
Val Ala Met Ala Leu Cys Asp Gly Ser Arg Glu Cys Pro Pro His Leu
        35                  40                  45              
Pro Met Val Leu Pro Arg Pro Pro Arg Ala Gly Ser Gln Pro Leu Cys
    50                  55                  60                  
Pro Pro Ala Ala Thr Glu Gly Glu Leu Pro Thr His Glu Gln Val Phe
65                  70                  75                  80  
Leu Gln Pro Pro Thr Ser Ser Lys Pro Arg Gly Pro Val Leu Pro Gln
                85                  90                  95      
Glu Leu Glu Glu Arg Arg Gln Leu Gly Lys Ala His Leu Lys Arg Ala
            100                 105                 110         
Ile Leu Gly Gln Glu Glu Ala Leu Arg Leu His Ala Leu Cys Arg Val
        115                 120                 125             
Leu Arg Glu Val Asp Leu Leu Arg Ala Val Ile Ser Gln Thr Leu Gln
    130                 135                 140                 
Arg Ser Leu Ala Lys Tyr Ala Glu Leu Asp Arg Glu Asp Asp Phe Cys
145                 150                 155                 160 
Glu Ala Ala Glu Ala Pro Asp Ile Gln Pro Lys Thr His Gln Lys Pro
                165                 170                 175     
Glu Ala Arg Met Pro Arg Leu Ser Gln Gly Lys Gly Pro Asp Ile Phe
            180                 185                 190         
His Arg Leu Gly Pro Leu Ser Val Phe Ser Ala Lys Asn Arg Trp Arg
        195                 200                 205             
Leu Val Gly Pro Val His Leu Thr Arg Gly Glu Gly Gly Phe Gly Leu
    210                 215                 220                 
Thr Leu Arg Gly Asp Ser Pro Val Leu Ile Ala Ala Val Ile Pro Gly
225                 230                 235                 240 
Ser Gln Ala Ala Ala Ala Gly Leu Lys Glu Gly Asp Tyr Ile Val Ser
                245                 250                 255     
Val Asn Gly Gln Pro Cys Arg Trp Trp Arg His Ala Glu Val Val Thr
            260                 265                 270         
Glu Leu Lys Ala Ala Gly Glu Ala Gly Ala Ser Leu Gln Val Val Ser
        275                 280                 285             
Leu Leu Pro Ser Ser Arg Leu Pro Ser Leu Gly Asp Arg Arg Pro Val
    290                 295                 300                 
Leu Leu Gly Pro Gly Arg Leu
305                 310     


<210> 2466
<211> 941
<212> PRT
<213> Homo sapiens

<400> 2466
Met Ala Ser Pro Arg Ser Ser Gly Gln Pro Gly Pro Pro Pro Pro Pro
 1               5                  10                  15      
Pro Pro Pro Pro Ala Arg Leu Leu Leu Leu Leu Leu Leu Pro Leu Leu
            20                  25                  30          
Leu Pro Leu Ala Pro Gly Ala Trp Gly Trp Ala Arg Gly Ala Pro Arg
        35                  40                  45              
Pro Pro Pro Ser Ser Pro Pro Leu Ser Ile Met Gly Leu Met Pro Leu
    50                  55                  60                  
Thr Lys Glu Val Ala Lys Gly Ser Ile Gly Arg Gly Val Leu Pro Ala
65                  70                  75                  80  
Val Glu Leu Ala Ile Glu Gln Ile Arg Asn Glu Ser Leu Leu Arg Pro
                85                  90                  95      
Tyr Phe Leu Asp Leu Arg Leu Tyr Asp Thr Glu Cys Asp Asn Ala Lys
            100                 105                 110         
Gly Leu Lys Ala Phe Tyr Asp Ala Ile Lys Tyr Gly Pro Asn His Leu
        115                 120                 125             
Met Val Phe Gly Gly Val Cys Pro Ser Val Thr Ser Ile Ile Ala Glu
    130                 135                 140                 
Ser Leu Gln Gly Trp Asn Leu Val Gln Leu Ser Phe Ala Ala Thr Thr
145                 150                 155                 160 
Pro Val Leu Ala Asp Lys Lys Lys Tyr Pro Tyr Phe Phe Arg Thr Val
                165                 170                 175     
Pro Ser Asp Asn Ala Val Asn Pro Ala Ile Leu Lys Leu Leu Lys His
            180                 185                 190         
Tyr Gln Trp Lys Arg Val Gly Thr Leu Thr Gln Asp Val Gln Arg Phe
        195                 200                 205             
Ser Glu Val Arg Asn Asp Leu Thr Gly Val Leu Tyr Gly Glu Asp Ile
    210                 215                 220                 
Glu Ile Ser Asp Thr Glu Ser Phe Ser Asn Asp Pro Cys Thr Ser Val
225                 230                 235                 240 
Lys Lys Leu Lys Gly Asn Asp Val Arg Ile Ile Leu Gly Gln Phe Asp
                245                 250                 255     
Gln Asn Met Ala Ala Lys Val Phe Cys Cys Ala Tyr Glu Glu Asn Met
            260                 265                 270         
Tyr Gly Ser Lys Tyr Gln Trp Ile Ile Pro Gly Trp Tyr Glu Pro Ser
        275                 280                 285             
Trp Trp Glu Gln Val His Thr Glu Ala Asn Ser Ser Arg Cys Leu Arg
    290                 295                 300                 
Lys Asn Leu Leu Ala Ala Met Glu Gly Tyr Ile Gly Val Asp Phe Glu
305                 310                 315                 320 
Pro Leu Ser Ser Lys Gln Ile Lys Thr Ile Ser Gly Lys Thr Pro Gln
                325                 330                 335     
Gln Tyr Glu Arg Glu Tyr Asn Asn Lys Arg Ser Gly Val Gly Pro Ser
            340                 345                 350         
Lys Phe His Gly Tyr Ala Tyr Asp Gly Ile Trp Val Ile Ala Lys Thr
        355                 360                 365             
Leu Gln Arg Ala Met Glu Thr Leu His Ala Ser Ser Arg His Gln Arg
    370                 375                 380                 
Ile Gln Asp Phe Asn Tyr Thr Asp His Thr Leu Gly Arg Ile Ile Leu
385                 390                 395                 400 
Asn Ala Met Asn Glu Thr Asn Phe Phe Gly Val Thr Gly Gln Val Val
                405                 410                 415     
Phe Arg Asn Gly Glu Arg Met Gly Thr Ile Lys Phe Thr Gln Phe Gln
            420                 425                 430         
Asp Ser Arg Glu Val Lys Val Gly Glu Tyr Asn Ala Val Ala Asp Thr
        435                 440                 445             
Leu Glu Ile Ile Asn Asp Thr Ile Arg Phe Gln Gly Ser Glu Pro Pro
    450                 455                 460                 
Lys Asp Lys Thr Ile Ile Leu Glu Gln Leu Arg Lys Ile Ser Leu Pro
465                 470                 475                 480 
Leu Tyr Ser Ile Leu Ser Ala Leu Thr Ile Leu Gly Met Ile Met Ala
                485                 490                 495     
Ser Ala Phe Leu Phe Phe Asn Ile Lys Asn Arg Asn Gln Lys Leu Ile
            500                 505                 510         
Lys Met Ser Ser Pro Tyr Met Asn Asn Leu Ile Ile Leu Gly Gly Met
        515                 520                 525             
Leu Ser Tyr Ala Ser Ile Phe Leu Phe Gly Leu Asp Gly Ser Phe Val
    530                 535                 540                 
Ser Glu Lys Thr Phe Glu Thr Leu Cys Thr Val Arg Thr Trp Ile Leu
545                 550                 555                 560 
Thr Val Gly Tyr Thr Thr Ala Phe Gly Ala Met Phe Ala Lys Thr Trp
                565                 570                 575     
Arg Val His Ala Ile Phe Lys Asn Val Lys Met Lys Lys Lys Ile Ile
            580                 585                 590         
Lys Asp Gln Lys Leu Leu Val Ile Val Gly Gly Met Leu Leu Ile Asp
        595                 600                 605             
Leu Cys Ile Leu Ile Cys Trp Gln Ala Val Asp Pro Leu Arg Arg Thr
    610                 615                 620                 
Val Glu Lys Tyr Ser Met Glu Pro Asp Pro Ala Gly Arg Asp Ile Ser
625                 630                 635                 640 
Ile Arg Pro Leu Leu Glu His Cys Glu Asn Thr His Met Thr Ile Trp
                645                 650                 655     
Leu Gly Ile Val Tyr Ala Tyr Lys Gly Leu Leu Met Leu Phe Gly Cys
            660                 665                 670         
Phe Leu Ala Trp Glu Thr Arg Asn Val Ser Ile Pro Ala Leu Asn Asp
        675                 680                 685             
Ser Lys Tyr Ile Gly Met Ser Val Tyr Asn Val Gly Ile Met Cys Ile
    690                 695                 700                 
Ile Gly Ala Ala Val Ser Phe Leu Thr Arg Asp Gln Pro Asn Val Gln
705                 710                 715                 720 
Phe Cys Ile Val Ala Leu Val Ile Ile Phe Cys Ser Thr Ile Thr Leu
                725                 730                 735     
Cys Leu Val Phe Val Pro Lys Leu Ile Thr Leu Arg Thr Asn Pro Asp
            740                 745                 750         
Ala Ala Thr Gln Asn Arg Arg Phe Gln Phe Thr Gln Asn Gln Lys Lys
        755                 760                 765             
Glu Asp Ser Lys Thr Ser Thr Ser Val Thr Ser Val Asn Gln Ala Ser
    770                 775                 780                 
Thr Ser Arg Leu Glu Gly Leu Gln Ser Glu Asn His Arg Leu Arg Met
785                 790                 795                 800 
Lys Ile Thr Glu Leu Asp Lys Asp Leu Glu Glu Val Thr Met Gln Leu
                805                 810                 815     
Gln Asp Thr Pro Glu Lys Thr Thr Tyr Ile Lys Gln Asn His Tyr Gln
            820                 825                 830         
Glu Leu Asn Asp Ile Leu Asn Leu Gly Asn Phe Thr Glu Ser Thr Asp
        835                 840                 845             
Gly Gly Lys Ala Ile Leu Lys Asn His Leu Asp Gln Asn Pro Gln Leu
    850                 855                 860                 
Gln Trp Asn Thr Thr Glu Pro Ser Arg Thr Cys Lys Asp Pro Ile Glu
865                 870                 875                 880 
Asp Ile Asn Ser Pro Glu His Ile Gln Arg Arg Leu Ser Leu Gln Leu
                885                 890                 895     
Pro Ile Leu His His Ala Tyr Leu Pro Ser Ile Gly Gly Val Asp Ala
            900                 905                 910         
Ser Cys Val Ser Pro Cys Val Ser Pro Thr Ala Ser Pro Arg His Arg
        915                 920                 925             
His Val Pro Pro Ser Phe Arg Val Met Val Ser Gly Leu
    930                 935                 940     


<210> 2467
<211> 452
<212> PRT
<213> Homo sapiens

<400> 2467
Met Ala Gly Tyr Leu Arg Val Val Arg Ser Leu Cys Arg Ala Ser Gly
 1               5                  10                  15      
Ser Arg Pro Ala Trp Ala Pro Ala Ala Leu Thr Ala Pro Thr Ser Gln
            20                  25                  30          
Glu Gln Pro Arg Arg His Tyr Ala Asp Lys Arg Ile Lys Val Ala Lys
        35                  40                  45              
Pro Val Val Glu Met Asp Gly Asp Glu Met Thr Arg Ile Ile Trp Gln
    50                  55                  60                  
Phe Ile Lys Glu Lys Leu Ile Leu Pro His Val Asp Ile Gln Leu Lys
65                  70                  75                  80  
Tyr Phe Asp Leu Gly Leu Pro Asn Arg Asp Gln Thr Asp Asp Gln Val
                85                  90                  95      
Thr Ile Asp Ser Ala Leu Ala Thr Gln Lys Tyr Ser Val Ala Val Lys
            100                 105                 110         
Cys Ala Thr Ile Thr Pro Asp Glu Ala Arg Val Glu Glu Phe Lys Leu
        115                 120                 125             
Lys Lys Met Trp Lys Ser Pro Asn Gly Thr Ile Arg Asn Ile Leu Gly
    130                 135                 140                 
Gly Thr Val Phe Arg Glu Pro Ile Ile Cys Lys Asn Ile Pro Arg Leu
145                 150                 155                 160 
Val Pro Gly Trp Thr Lys Pro Ile Thr Ile Gly Arg His Ala His Gly
                165                 170                 175     
Asp Gln Tyr Lys Ala Thr Asp Phe Val Ala Asp Arg Ala Gly Thr Phe
            180                 185                 190         
Lys Met Val Phe Thr Pro Lys Asp Gly Ser Gly Val Lys Glu Trp Glu
        195                 200                 205             
Val Tyr Asn Phe Pro Ala Gly Gly Val Gly Met Gly Met Tyr Asn Thr
    210                 215                 220                 
Asp Glu Ser Ile Ser Gly Phe Ala His Ser Cys Phe Gln Tyr Ala Ile
225                 230                 235                 240 
Gln Lys Lys Trp Pro Leu Tyr Met Ser Thr Lys Asn Thr Ile Leu Lys
                245                 250                 255     
Ala Tyr Asp Gly Arg Phe Lys Asp Ile Phe Gln Glu Ile Phe Asp Lys
            260                 265                 270         
His Tyr Lys Thr Asp Phe Asp Lys Asn Lys Ile Trp Tyr Glu His Arg
        275                 280                 285             
Leu Ile Asp Asp Met Val Ala Gln Val Leu Lys Ser Ser Gly Gly Phe
    290                 295                 300                 
Val Trp Ala Cys Lys Asn Tyr Asp Gly Asp Val Gln Ser Asp Ile Leu
305                 310                 315                 320 
Ala Gln Gly Phe Gly Ser Leu Gly Leu Met Thr Ser Val Leu Val Cys
                325                 330                 335     
Pro Asp Gly Lys Thr Ile Glu Ala Glu Ala Ala His Gly Thr Val Thr
            340                 345                 350         
Arg His Tyr Arg Glu His Gln Lys Gly Arg Pro Thr Ser Thr Asn Pro
        355                 360                 365             
Ile Ala Ser Ile Phe Ala Trp Thr Arg Gly Leu Glu His Arg Gly Lys
    370                 375                 380                 
Leu Asp Gly Asn Gln Asp Leu Ile Arg Phe Ala Gln Met Leu Glu Lys
385                 390                 395                 400 
Val Cys Val Glu Thr Val Glu Ser Gly Ala Met Thr Lys Asp Leu Ala
                405                 410                 415     
Gly Cys Ile His Gly Leu Ser Asn Val Lys Leu Asn Glu His Phe Leu
            420                 425                 430         
Asn Thr Thr Asp Phe Leu Asp Thr Ile Lys Ser Asn Leu Asp Arg Ala
        435                 440                 445             
Leu Gly Arg Gln
    450         


<210> 2468
<211> 97
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85
<223> Xaa = Any Amino Acid

<400> 2468
Met Ala Leu Pro Leu Arg Pro Leu Thr Arg Gly Leu Ala Ser Ala Ala
 1               5                  10                  15      
Lys Gly Gly His Gly Gly Ala Gly Ala Arg Thr Trp Arg Leu Leu Thr
            20                  25                  30          
Phe Val Leu Ala Leu Pro Ser Val Ala Leu Cys Thr Phe Asn Ser Tyr
        35                  40                  45              
Leu His Ser Gly His Arg Pro Arg Pro Glu Phe Arg Pro Tyr Gln His
    50                  55                  60                  
Leu Arg Ile Arg Thr Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
65                  70                  75                  80  
Xaa Xaa Xaa Xaa Xaa His Val Asn Pro Leu Pro Thr Gly Tyr Glu His
                85                  90                  95      
Pro
    


<210> 2469
<211> 87
<212> PRT
<213> Homo sapiens

<400> 2469
Gly Ala Cys Cys Arg Lys Trp Glu Glu Arg Lys Val Val Met Ala Ala
 1               5                  10                  15      
Ile Ala Ala Ser Glu Val Leu Val Asp Ser Ala Glu Glu Gly Ser Leu
            20                  25                  30          
Ala Ala Ala Ala Glu Leu Ala Ala Gln Lys Arg Glu Gln Arg Leu Arg
        35                  40                  45              
Lys Phe Arg Glu Leu His Leu Met Arg Val Ser Ser Leu Gly Gly Arg
    50                  55                  60                  
Leu Arg Ser Val Ile Trp Pro Ser Leu Cys Ala Phe Val Glu Gly Thr
65                  70                  75                  80  
Arg Lys Pro His His Cys Val
                85          


<210> 2470
<211> 479
<212> PRT
<213> Homo sapiens

<400> 2470
Met Ala Ala Ala Arg Glu Pro Glu Leu Pro Gln Glu Ala Pro Ala Thr
 1               5                  10                  15      
Glu Pro Ala Pro Pro Pro Ala Cys Arg Phe Phe Leu Glu Gly Arg Cys
            20                  25                  30          
Arg Phe Gly Ala Arg Cys Arg Gln Pro His Pro Gly Ala Pro Ala Pro
        35                  40                  45              
Pro Gly Arg Glu Ala Gln Pro Glu Ala Gly Ala Lys Lys Pro Pro Leu
    50                  55                  60                  
Arg Thr Ala Ala Asp Val Ile Gln Arg Ile Arg Trp Asp Pro Arg Leu
65                  70                  75                  80  
Asp Pro Ala Asp Phe Ser Val Gly Tyr Val Asp Arg Phe Leu Gly Val
                85                  90                  95      
Arg Glu Glu Pro Phe Ser Ala Phe Cys Trp Asp Gln Pro Leu Ala Ala
            100                 105                 110         
Leu Gly Pro Gly Val Leu Ala Val Pro Gln His Arg Val Arg Phe Phe
        115                 120                 125             
Arg Phe His Gly Arg Leu Val Trp Asp Arg Ala Ser Arg Thr Asp Leu
    130                 135                 140                 
Val Phe Gly Ser Gly Ser Ala Ala Gly Arg Gly Pro Thr Ile Leu Asp
145                 150                 155                 160 
Ala Pro Asn Thr Glu Gly Ala His Gly Ala Glu Gly Ala Glu Trp Thr
                165                 170                 175     
Leu Ala Gly Thr Gly Gln Glu Ala Gln Ala Ala Pro Lys Arg Gly Ser
            180                 185                 190         
Thr Arg Pro Leu Cys Thr Gly His Gln Glu Pro Gly Val Glu Glu Pro
        195                 200                 205             
Gly Glu Leu Glu Ala Ala Gln Glu Arg Ala Leu Gly Thr Ala Ala Asp
    210                 215                 220                 
Leu Gly Thr Leu Ala Pro Arg Gly Arg Leu Ala Gly Val Thr Glu Glu
225                 230                 235                 240 
Ala Leu Lys Pro Thr Ala Ala Thr Arg Thr Thr Leu Leu Gly Gly Lys
                245                 250                 255     
Glu Ala Gln Ala Leu Gly Val Pro Gly Gly Ser Ala Glu Thr Thr Glu
            260                 265                 270         
Ala Glu Trp Gly Pro Ala Ala Trp Pro Glu Asp Lys Arg Ala Arg Leu
        275                 280                 285             
Ser Val Ala Ala Pro Cys Gln Pro Arg Pro Thr His Phe Val Ala Leu
    290                 295                 300                 
Met Val Thr Glu Pro Gly Leu Gln Ala Glu Val Thr Lys Ala Gln Glu
305                 310                 315                 320 
Tyr Leu Val His Val Ala Pro His Cys Ala Asn Phe Leu Val Pro Ser
                325                 330                 335     
Gln Asn Leu His Leu Thr Leu Ala Leu Leu Arg Leu Ala Gly Ala Gly
            340                 345                 350         
Glu Glu Ala Ala Ala Ile Gly Ala Leu Arg Arg Ala Leu Leu Ala Pro
        355                 360                 365             
Gly Leu Asn Ala Pro Pro Arg Leu Ser Phe Arg Lys Leu Val Leu Leu
    370                 375                 380                 
Gly Pro His Val Leu Cys Ala Pro Pro Ser Pro Thr Leu Glu Ser Met
385                 390                 395                 400 
Ala Gln Val Leu Ser Gln Arg Leu Glu Ala Glu Gly Leu Ser Thr Leu
                405                 410                 415     
Gln Ser Pro Gly Gln Leu His Pro His Leu Thr Val Ala Lys Val Pro
            420                 425                 430         
His Gly Ser Gln Val His Leu Pro Lys Leu Glu Phe Thr Leu Ser Gln
        435                 440                 445             
Glu Val Gly Cys Gln Pro Leu Gln Thr Leu Trp Leu Cys Arg Ile Gly
    450                 455                 460                 
Arg Thr Gly Gly Pro Phe Gln Pro Leu Ala Glu Ile Arg Leu Glu
465                 470                 475                 


<210> 2471
<211> 801
<212> PRT
<213> Homo sapiens

<400> 2471
Met Trp Thr Ser Gly Arg Met Ser Asn Ala Lys Asn Trp Leu Gly Leu
 1               5                  10                  15      
Gly Met Ser Leu Tyr Phe Trp Gly Leu Met Asp Leu Thr Thr Thr Val
            20                  25                  30          
Leu Ser Asp Thr Pro Thr Pro Gln Gly Glu Leu Glu Ala Leu Leu Ser
        35                  40                  45              
Asp Lys Pro Gln Ser His Gln Arg Thr Lys Arg Ser Trp Val Trp Asn
    50                  55                  60                  
Gln Phe Phe Val Leu Glu Glu Tyr Thr Gly Thr Asp Pro Leu Tyr Val
65                  70                  75                  80  
Gly Lys Leu His Ser Asp Met Asp Arg Gly Asp Gly Ser Ile Lys Tyr
                85                  90                  95      
Ile Leu Ser Gly Glu Gly Ala Gly Ile Val Phe Thr Ile Asp Asp Thr
            100                 105                 110         
Thr Gly Asp Ile His Ala Ile Gln Arg Leu Asp Arg Glu Glu Arg Ala
        115                 120                 125             
Gln Tyr Thr Leu Arg Ala Gln Ala Leu Asp Arg Arg Thr Gly Arg Pro
    130                 135                 140                 
Met Glu Pro Glu Ser Glu Phe Ile Ile Lys Ile Gln Asp Ile Asn Asp
145                 150                 155                 160 
Asn Glu Pro Lys Phe Leu Asp Gly Pro Tyr Val Ala Thr Val Pro Glu
                165                 170                 175     
Met Ser Pro Val Gly Thr Ser Val Ile Gln Val Thr Ala Thr Asp Ala
            180                 185                 190         
Asp Asp Pro Thr Tyr Gly Asn Ser Ala Arg Val Val Tyr Ser Ile Leu
        195                 200                 205             
Gln Gly Gln Pro Tyr Phe Ser Val Asp Ser Lys Thr Gly Val Ile Arg
    210                 215                 220                 
Thr Ala Leu Met Asn Met Asp Arg Glu Ala Lys Glu Tyr Tyr Glu Val
225                 230                 235                 240 
Ile Ile Gln Ala Lys Asp Met Gly Gly Gln Leu Gly Gly Leu Ala Gly
                245                 250                 255     
Thr Thr Thr Val Asn Ile Thr Leu Ser Asp Val Asn Asp Asn Pro Pro
            260                 265                 270         
Arg Phe Pro Gln Lys His Tyr Gln Met Ser Val Leu Glu Ser Ala Pro
        275                 280                 285             
Ile Ser Ser Thr Val Gly Arg Val Phe Ala Lys Asp Leu Asp Glu Gly
    290                 295                 300                 
Ile Asn Ala Glu Met Lys Tyr Thr Ile Val Asp Gly Asp Gly Ala Asp
305                 310                 315                 320 
Ala Phe Asp Ile Ser Thr Asp Pro Asn Phe Gln Val Gly Ile Ile Thr
                325                 330                 335     
Val Lys Lys Pro Leu Ser Phe Glu Ser Lys Lys Ser Tyr Thr Leu Lys
            340                 345                 350         
Val Glu Gly Ala Asn Pro His Leu Glu Met Arg Phe Leu Asn Leu Gly
        355                 360                 365             
Pro Phe Gln Asp Thr Thr Thr Val His Ile Ser Val Glu Asp Val Asp
    370                 375                 380                 
Glu Pro Pro Val Phe Glu Pro Gly Phe Tyr Phe Val Glu Val Pro Glu
385                 390                 395                 400 
Asp Val Ala Ile Gly Thr Thr Ile Gln Ile Ile Ser Ala Lys Asp Pro
                405                 410                 415     
Asp Val Thr Asn Asn Ser Ile Arg Tyr Ser Ile Asp Arg Ser Ser Asp
            420                 425                 430         
Pro Gly Arg Phe Phe Tyr Val Asp Ile Thr Thr Gly Ala Leu Met Thr
        435                 440                 445             
Ala Arg Pro Leu Asp Arg Glu Glu Phe Ser Trp His Asn Ile Thr Val
    450                 455                 460                 
Leu Ala Met Glu Met Asn Asn Pro Ser Gln Val Gly Ser Val Pro Val
465                 470                 475                 480 
Thr Ile Lys Val Leu Asp Val Asn Asp Asn Ala Pro Glu Phe Pro Arg
                485                 490                 495     
Phe Tyr Glu Ala Phe Val Cys Glu Asn Ala Lys Ala Gly Gln Leu Ile
            500                 505                 510         
Gln Thr Val Ser Ala Val Asp Gln Asp Asp Pro Arg Asn Gly Gln His
        515                 520                 525             
Phe Tyr Tyr Ser Leu Ala Pro Glu Ala Ala Asn Asn Pro Asn Phe Thr
    530                 535                 540                 
Ile Arg Asp Asn Gln Asp Asn Thr Ala Arg Ile Leu Thr Arg Arg Ser
545                 550                 555                 560 
Gly Phe Arg Gln Gln Glu Gln Ser Val Phe His Leu Pro Ile Leu Ile
                565                 570                 575     
Ala Asp Ser Gly Gln Pro Val Leu Ser Ser Thr Gly Thr Leu Thr Ile
            580                 585                 590         
Gln Val Cys Ser Cys Asp Asp Asp Gly His Val Met Ser Cys Ser Pro
        595                 600                 605             
Glu Ala Tyr Met Leu Pro Val Ser Leu Ser Arg Gly Ala Leu Ile Ala
    610                 615                 620                 
Ile Leu Ala Cys Ile Phe Val Leu Leu Val Leu Val Leu Leu Ile Leu
625                 630                 635                 640 
Ser Met Arg Arg His Arg Lys Gln Pro Tyr Ile Ile Asp Asp Glu Glu
                645                 650                 655     
Asn Ile His Glu Asn Ile Val Arg Tyr Asp Asp Glu Gly Gly Gly Glu
            660                 665                 670         
Glu Asp Thr Glu Ala Phe Asp Ile Ala Ala Met Trp Asn Pro Arg Glu
        675                 680                 685             
Ala Gln Ala Gly Ala Ala Pro Lys Thr Arg Gln Asp Met Leu Pro Glu
    690                 695                 700                 
Ile Glu Ser Leu Ser Arg Tyr Val Pro Gln Thr Cys Ala Val Asn Ser
705                 710                 715                 720 
Thr Val His Ser Tyr Val Leu Ala Lys Leu Tyr Glu Ala Asp Met Asp
                725                 730                 735     
Leu Trp Ala Pro Pro Phe Asp Ser Leu Gln Thr Tyr Met Phe Glu Gly
            740                 745                 750         
Asp Gly Ser Val Ala Gly Ser Leu Ser Ser Leu Gln Ser Ala Thr Ser
        755                 760                 765             
Asp Ser Glu Gln Ser Phe Asp Phe Leu Thr Asp Trp Gly Pro Arg Phe
    770                 775                 780                 
Arg Lys Leu Ala Glu Leu Tyr Gly Ala Ser Glu Gly Pro Ala Pro Leu
785                 790                 795                 800 
Trp
    


<210> 2472
<211> 194
<212> PRT
<213> Homo sapiens

<400> 2472
Ala Gly Ala Arg Arg Leu Glu Leu Gly Glu Ala Leu Ala Leu Gly Ser
 1               5                  10                  15      
Gly Trp Arg His Ala Cys His Ala Leu Leu Tyr Ala Pro Asp Pro Gly
            20                  25                  30          
Met Leu Phe Gly Arg Ile Pro Leu Arg Tyr Ala Ile Leu Met Gln Met
        35                  40                  45              
Arg Phe Asp Gly Arg Leu Gly Phe Pro Gly Gly Phe Val Asp Thr Gln
    50                  55                  60                  
Asp Arg Ser Leu Glu Asp Gly Leu Asn Arg Glu Leu Arg Glu Glu Leu
65                  70                  75                  80  
Gly Glu Ala Ala Ala Ala Phe Arg Val Glu Arg Thr Asp Tyr Arg Ser
                85                  90                  95      
Ser His Val Gly Ser Gly Pro Arg Val Val Ala His Phe Tyr Ala Lys
            100                 105                 110         
Arg Leu Thr Leu Glu Glu Leu Leu Ala Val Glu Ala Gly Ala Thr Arg
        115                 120                 125             
Ala Lys Asp His Gly Leu Glu Val Leu Gly Leu Val Arg Val Pro Leu
    130                 135                 140                 
Tyr Thr Leu Arg Asp Gly Val Gly Gly Leu Pro Thr Phe Leu Glu Asn
145                 150                 155                 160 
Ser Phe Ile Gly Ser Ala Arg Glu Gln Leu Leu Glu Ala Leu Gln Asp
                165                 170                 175     
Leu Gly Leu Leu Gln Ser Gly Ser Ile Ser Gly Leu Lys Ile Pro Ala
            180                 185                 190         
His His
        


<210> 2473
<211> 339
<212> PRT
<213> Homo sapiens

<400> 2473
Met Ser Thr Val His Glu Ile Leu Cys Lys Leu Ser Leu Glu Gly Asp
 1               5                  10                  15      
His Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Ala Tyr Thr Asn
            20                  25                  30          
Phe Asp Ala Glu Arg Asp Ala Leu Asn Ile Glu Thr Ala Ile Lys Thr
        35                  40                  45              
Lys Gly Val Asp Glu Val Thr Ile Val Asn Ile Leu Thr Asn Arg Ser
    50                  55                  60                  
Asn Ala Gln Arg Gln Asp Ile Ala Phe Ala Tyr Gln Arg Arg Thr Lys
65                  70                  75                  80  
Lys Glu Leu Ala Ser Ala Leu Lys Ser Ala Leu Ser Gly His Leu Glu
                85                  90                  95      
Thr Leu Ile Leu Gly Leu Leu Lys Thr Pro Ala Gln Tyr Asp Ala Ser
            100                 105                 110         
Glu Leu Lys Ala Ser Met Lys Gly Leu Gly Thr Asp Glu Asp Ser Leu
        115                 120                 125             
Ile Glu Ile Ile Cys Ser Arg Thr Asn Gln Glu Leu Gln Glu Ile Asn
    130                 135                 140                 
Arg Val Tyr Lys Glu Met Tyr Lys Thr Asp Leu Glu Lys Asp Ile Ile
145                 150                 155                 160 
Ser Asp Thr Ser Gly Asp Phe Arg Lys Leu Met Val Ala Leu Ala Lys
                165                 170                 175     
Gly Arg Arg Ala Glu Asp Gly Ser Val Ile Asp Tyr Glu Leu Ile Asp
            180                 185                 190         
Gln Asp Ala Arg Asp Leu Tyr Asp Ala Gly Val Lys Arg Lys Gly Thr
        195                 200                 205             
Asp Val Pro Lys Trp Ile Ser Ile Met Thr Glu Arg Ser Val Pro His
    210                 215                 220                 
Leu Gln Lys Val Phe Asp Arg Tyr Lys Ser Tyr Ser Pro Tyr Asp Met
225                 230                 235                 240 
Leu Glu Ser Ile Arg Lys Glu Val Lys Gly Asp Leu Glu Asn Ala Phe
                245                 250                 255     
Leu Asn Leu Val Gln Cys Ile Gln Asn Lys Pro Leu Tyr Phe Ala Asp
            260                 265                 270         
Arg Leu Tyr Asp Ser Met Lys Gly Lys Gly Thr Arg Asp Lys Val Leu
        275                 280                 285             
Ile Arg Ile Met Val Ser Arg Ser Glu Val Asp Met Leu Lys Ile Arg
    290                 295                 300                 
Ser Glu Phe Lys Arg Lys Tyr Gly Lys Ser Leu Tyr Tyr Tyr Ile Gln
305                 310                 315                 320 
Gln Asp Thr Lys Gly Asp Tyr Gln Lys Ala Leu Leu Tyr Leu Cys Gly
                325                 330                 335     
Gly Asp Asp
            


<210> 2474
<211> 314
<212> PRT
<213> Homo sapiens

<400> 2474
Met Ala Leu Ala Ala Arg Leu Trp Arg Leu Leu Pro Phe Arg Arg Gly
 1               5                  10                  15      
Ala Ala Pro Gly Ser Arg Leu Pro Ala Gly Thr Ser Gly Ser Arg Gly
            20                  25                  30          
His Cys Gly Pro Cys Arg Phe Arg Gly Phe Glu Val Met Gly Asn Pro
        35                  40                  45              
Gly Thr Phe Lys Arg Gly Leu Leu Leu Ser Ala Leu Ser Tyr Leu Gly
    50                  55                  60                  
Phe Glu Thr Tyr Gln Val Ile Ser Gln Ala Ala Val Val His Ala Thr
65                  70                  75                  80  
Ala Lys Val Glu Glu Ile Leu Glu Gln Ala Asp Tyr Leu Tyr Glu Ser
                85                  90                  95      
Gly Glu Thr Glu Lys Leu Tyr Gln Leu Leu Thr Gln Tyr Lys Glu Ser
            100                 105                 110         
Glu Asp Ala Glu Leu Leu Trp Arg Leu Ala Arg Ala Ser Arg Asp Val
        115                 120                 125             
Ala Gln Leu Ser Arg Thr Ser Glu Glu Glu Lys Lys Leu Leu Val Tyr
    130                 135                 140                 
Glu Ala Leu Glu Tyr Ala Lys Arg Ala Leu Glu Lys Asn Glu Ser Ser
145                 150                 155                 160 
Phe Ala Ser His Lys Trp Tyr Ala Ile Cys Leu Ser Asp Val Gly Asp
                165                 170                 175     
Tyr Glu Gly Ile Lys Ala Lys Ile Ala Asn Ala Tyr Ile Ile Lys Glu
            180                 185                 190         
His Phe Glu Lys Ala Ile Glu Leu Asn Pro Lys Asp Ala Thr Ser Ile
        195                 200                 205             
His Leu Met Gly Ile Trp Cys Tyr Thr Phe Ala Glu Met Pro Trp Tyr
    210                 215                 220                 
Gln Arg Arg Ile Ala Lys Met Leu Phe Ala Thr Pro Pro Ser Ser Thr
225                 230                 235                 240 
Tyr Glu Lys Ala Leu Gly Tyr Phe His Arg Ala Glu Gln Val Asp Pro
                245                 250                 255     
Asn Phe Tyr Ser Lys Asn Leu Leu Leu Leu Gly Lys Thr Tyr Leu Lys
            260                 265                 270         
Leu His Asn Lys Lys Leu Ala Ala Phe Trp Leu Met Lys Ala Lys Asp
        275                 280                 285             
Tyr Pro Ala His Thr Glu Glu Asp Lys Gln Ile Gln Thr Glu Ala Ala
    290                 295                 300                 
Gln Leu Leu Thr Ser Phe Ser Glu Lys Asn
305                 310                 


<210> 2475
<211> 116
<212> PRT
<213> Homo sapiens

<400> 2475
Met Ala Ser Thr Val Val Ala Val Gly Leu Thr Ile Ala Ala Ala Gly
 1               5                  10                  15      
Phe Ala Gly Arg Tyr Val Leu Gln Ala Met Lys His Met Glu Pro Gln
            20                  25                  30          
Val Lys Gln Val Phe Gln Ser Leu Pro Lys Ser Ala Phe Ser Gly Gly
        35                  40                  45              
Tyr Tyr Arg Gly Gly Phe Glu Pro Lys Met Thr Lys Arg Glu Ala Ala
    50                  55                  60                  
Leu Ile Leu Gly Val Ser Pro Thr Ala Asn Lys Gly Lys Ile Arg Asp
65                  70                  75                  80  
Ala His Arg Arg Ile Met Leu Leu Asn His Pro Asp Lys Gly Gly Ser
                85                  90                  95      
Pro Tyr Ile Ala Ala Lys Ile Asn Glu Ala Lys Asp Leu Leu Glu Gly
            100                 105                 110         
Gln Ala Lys Lys
        115     


<210> 2476
<211> 31
<212> PRT
<213> Homo sapiens

<400> 2476
Lys Glu Gln Gly Thr Ala Gly Gly Lys Arg His Phe Thr Phe Gln Cys
 1               5                  10                  15      
Lys Ser Cys Ser Phe Asp Leu Met Gly Cys Thr Gly Ala Arg Gly
            20                  25                  30      


<210> 2477
<211> 702
<212> PRT
<213> Homo sapiens

<400> 2477
Glu Asn Met Gln Lys Ala Leu Glu Leu Lys Ala Lys Tyr Glu Ser Asp
 1               5                  10                  15      
Met Val Thr Gly Gly Tyr Ala Ala Leu Ile Asn Leu Cys Cys Arg His
            20                  25                  30          
Asp Lys Val Glu Asp Ala Leu Asn Leu Lys Glu Glu Phe Asp Arg Leu
        35                  40                  45              
Asp Ser Ser Ala Val Leu Asp Thr Gly Lys Tyr Val Gly Leu Val Arg
    50                  55                  60                  
Val Leu Ala Lys His Gly Lys Leu Gln Asp Ala Ile Asn Ile Leu Lys
65                  70                  75                  80  
Glu Met Lys Glu Lys Asp Val Leu Ile Lys Asp Thr Thr Ala Leu Ser
                85                  90                  95      
Phe Phe His Met Leu Asn Gly Ala Ala Leu Arg Gly Glu Ile Glu Thr
            100                 105                 110         
Val Lys Gln Leu His Glu Ala Ile Val Thr Leu Gly Leu Ala Glu Pro
        115                 120                 125             
Ser Thr Asn Ile Ser Phe Pro Leu Val Thr Val His Leu Glu Lys Gly
    130                 135                 140                 
Asp Leu Ser Thr Ala Leu Glu Val Ala Ile Asp Cys Tyr Glu Lys Tyr
145                 150                 155                 160 
Lys Val Leu Pro Arg Ile His Asp Val Leu Cys Lys Leu Val Glu Lys
                165                 170                 175     
Gly Glu Thr Asp Leu Ile Gln Lys Ala Met Asp Phe Val Ser Gln Glu
            180                 185                 190         
Gln Gly Glu Met Val Met Leu Tyr Asp Leu Phe Phe Ala Phe Leu Gln
        195                 200                 205             
Thr Gly Asn Tyr Lys Glu Ala Lys Lys Ile Ile Glu Thr Pro Gly Ile
    210                 215                 220                 
Arg Ala Arg Ser Ala Arg Leu Gln Trp Phe Cys Asp Arg Cys Val Ala
225                 230                 235                 240 
Asn Asn Gln Val Glu Thr Leu Glu Lys Leu Val Glu Leu Thr Gln Lys
                245                 250                 255     
Leu Phe Glu Cys Asp Arg Asp Gln Met Tyr Tyr Asn Leu Leu Lys Leu
            260                 265                 270         
Tyr Lys Ile Asn Gly Asp Trp Gln Arg Ala Asp Ala Val Trp Asn Lys
        275                 280                 285             
Ile Gln Glu Glu Asn Val Ile Pro Arg Glu Lys Thr Leu Arg Leu Leu
    290                 295                 300                 
Ala Glu Ile Leu Arg Glu Gly Asn Gln Glu Val Pro Phe Asp Val Pro
305                 310                 315                 320 
Glu Leu Trp Tyr Glu Asp Glu Lys His Ser Leu Asn Ser Ser Ser Ala
                325                 330                 335     
Ser Thr Thr Glu Pro Asp Phe Gln Lys Asp Ile Leu Ile Ala Cys Arg
            340                 345                 350         
Leu Asn Gln Lys Lys Gly Ala Tyr Asp Ile Phe Leu Asn Ala Lys Glu
        355                 360                 365             
Gln Asn Ile Val Phe Asn Ala Glu Thr Tyr Ser Asn Leu Ile Lys Leu
    370                 375                 380                 
Leu Met Ser Glu Asp Tyr Phe Thr Gln Ala Met Glu Val Lys Ala Phe
385                 390                 395                 400 
Ala Glu Thr His Ile Lys Gly Phe Thr Leu Asn Asp Ala Ala Asn Ser
                405                 410                 415     
Arg Leu Ile Ile Thr Gln Val Arg Arg Asp Tyr Leu Lys Glu Ala Val
            420                 425                 430         
Thr Thr Leu Lys Thr Val Leu Asp Gln Gln Gln Thr Pro Ser Arg Leu
        435                 440                 445             
Ala Val Thr Arg Val Ile Gln Ala Leu Ala Met Lys Gly Asp Val Glu
    450                 455                 460                 
Asn Ile Glu Val Val Gln Lys Met Leu Asn Gly Leu Glu Asp Ser Ile
465                 470                 475                 480 
Gly Leu Ser Lys Met Val Phe Ile Asn Asn Ile Ala Leu Ala Gln Ile
                485                 490                 495     
Lys Asn Asn Asn Ile Asp Ala Ala Ile Glu Asn Ile Glu Asn Met Leu
            500                 505                 510         
Thr Ser Glu Asn Lys Val Ile Glu Pro Gln Tyr Phe Gly Leu Ala Tyr
        515                 520                 525             
Leu Phe Arg Lys Val Ile Glu Glu Gln Leu Glu Pro Ala Val Glu Lys
    530                 535                 540                 
Ile Ser Ile Met Ala Glu Arg Leu Ala Asn Gln Phe Ala Ile Tyr Lys
545                 550                 555                 560 
Pro Val Thr Asp Phe Phe Leu Gln Leu Val Asp Ala Gly Lys Val Asp
                565                 570                 575     
Asp Ala Arg Ala Leu Leu Gln Arg Cys Gly Ala Ile Ala Glu Gln Thr
            580                 585                 590         
Pro Ile Leu Leu Leu Phe Leu Leu Arg Asn Ser Arg Lys Gln Gly Lys
        595                 600                 605             
Ala Ser Thr Val Lys Ser Val Leu Glu Leu Ile Pro Glu Leu Asn Glu
    610                 615                 620                 
Lys Glu Glu Ala Tyr Asn Ser Leu Met Lys Ser Tyr Val Ser Glu Lys
625                 630                 635                 640 
Asp Val Thr Ser Ala Lys Ala Leu Tyr Glu His Leu Thr Ala Lys Asn
                645                 650                 655     
Thr Lys Leu Asp Asp Leu Phe Leu Lys Arg Tyr Ala Ser Leu Leu Lys
            660                 665                 670         
Tyr Ala Gly Glu Pro Val Pro Phe Ile Glu Pro Pro Glu Ser Phe Glu
        675                 680                 685             
Phe Tyr Ala Gln Gln Leu Arg Lys Leu Arg Glu Asn Ser Ser
    690                 695                 700         


<210> 2478
<211> 542
<212> PRT
<213> Homo sapiens

<400> 2478
Met Val Ala His Asp Glu Thr Gly Gly Leu Leu Pro Ile Lys Arg Thr
 1               5                  10                  15      
Ile Arg Val Leu Asp Val Asn Asn Gln Ser Phe Arg Glu Gln Glu Glu
            20                  25                  30          
Pro Ser Asn Lys Arg Val Arg Pro Leu Ala Arg Val Thr Ser Leu Ala
        35                  40                  45              
Asn Leu Ile Ser Pro Val Arg Asn Gly Ala Val Arg Arg Phe Gly Gln
    50                  55                  60                  
Thr Ile Gln Ser Phe Thr Leu Arg Gly Asp His Arg Ser Pro Ala Ser
65                  70                  75                  80  
Ala Gln Lys Phe Ser Ser Arg Ser Thr Val Pro Thr Pro Ala Lys Arg
                85                  90                  95      
Arg Ser Ser Ala Leu Trp Ser Glu Met Leu Asp Ile Thr Met Lys Glu
            100                 105                 110         
Ser Leu Thr Thr Arg Glu Ile Arg Arg Gln Glu Ala Ile Tyr Glu Met
        115                 120                 125             
Ser Arg Gly Glu Gln Asp Leu Ile Glu Asp Leu Lys Leu Ala Arg Lys
    130                 135                 140                 
Ala Tyr His Asp Pro Met Leu Lys Leu Ser Ile Met Ser Glu Glu Glu
145                 150                 155                 160 
Leu Thr His Ile Phe Gly Asp Leu Asp Ser Tyr Ile Pro Leu His Glu
                165                 170                 175     
Asp Leu Leu Thr Arg Ile Gly Glu Ala Thr Lys Pro Asp Gly Thr Val
            180                 185                 190         
Glu Gln Ile Gly His Ile Leu Val Ser Trp Leu Pro Arg Leu Asn Ala
        195                 200                 205             
Tyr Arg Gly Tyr Cys Ser Asn Gln Leu Ala Ala Lys Ala Leu Leu Asp
    210                 215                 220                 
Gln Lys Lys Gln Asp Pro Arg Val Gln Asp Phe Leu Gln Arg Cys Leu
225                 230                 235                 240 
Glu Ser Pro Phe Ser Arg Lys Leu Asp Leu Trp Ser Phe Leu Asp Ile
                245                 250                 255     
Pro Arg Ser Arg Leu Val Lys Tyr Pro Leu Leu Leu Lys Glu Ile Leu
            260                 265                 270         
Lys His Thr Pro Lys Glu His Pro Asp Val Gln Leu Leu Glu Asp Ala
        275                 280                 285             
Ile Leu Ile Ile Gln Gly Val Leu Ser Asp Ile Asn Leu Lys Lys Gly
    290                 295                 300                 
Glu Ser Glu Cys Gln Tyr Tyr Ile Asp Lys Leu Glu Tyr Leu Asp Glu
305                 310                 315                 320 
Lys Gln Arg Asp Pro Arg Ile Glu Ala Ser Lys Val Leu Leu Cys His
                325                 330                 335     
Gly Glu Leu Arg Ser Lys Ser Gly His Lys Leu Tyr Ile Phe Leu Phe
            340                 345                 350         
Gln Asp Ile Leu Val Leu Thr Arg Pro Val Thr Arg Asn Glu Arg His
        355                 360                 365             
Ser Tyr Gln Val Tyr Arg Gln Pro Ile Pro Val Gln Glu Leu Val Leu
    370                 375                 380                 
Glu Asp Leu Gln Asp Gly Asp Val Arg Met Gly Gly Ser Phe Arg Gly
385                 390                 395                 400 
Ala Phe Ser Asn Ser Glu Lys Ala Lys Asn Ile Phe Arg Ile Arg Phe
                405                 410                 415     
His Asp Pro Ser Pro Ala Gln Ser His Thr Leu Gln Ala Asn Asp Val
            420                 425                 430         
Phe His Lys Gln Gln Trp Phe Asn Cys Ile Arg Ala Ala Ile Ala Pro
        435                 440                 445             
Phe Gln Ser Ala Gly Ser Pro Pro Glu Leu Gln Gly Leu Pro Glu Leu
    450                 455                 460                 
His Glu Glu Cys Glu Gly Asn His Pro Ser Ala Arg Lys Leu Thr Ala
465                 470                 475                 480 
Gln Arg Arg Ala Ser Thr Val Ser Ser Val Thr Gln Val Glu Val Asp
                485                 490                 495     
Glu Asn Ala Tyr Arg Cys Gly Ser Gly Met Gln Met Ala Glu Asp Ser
            500                 505                 510         
Lys Ser Leu Lys Thr His Gln Thr Gln Pro Gly Ile Arg Arg Ala Arg
        515                 520                 525             
Asp Lys Ala Leu Ser Gly Gly Lys Arg Lys Glu Thr Leu Val
    530                 535                 540         


<210> 2479
<211> 278
<212> PRT
<213> Homo sapiens

<400> 2479
Met Gly Lys Ser Ser Glu Trp Cys Glu Arg Ile Ala Gly Ile Gln Lys
 1               5                  10                  15      
Phe Val Leu Glu Lys Trp Thr Lys Lys Ala Lys Pro Glu Asp Thr Leu
            20                  25                  30          
Asn Leu Cys Gln Leu Leu Asn Asn Asp Leu Ala Ser Thr Val Val Ser
        35                  40                  45              
Tyr Pro Arg Arg Phe Val Gly Leu Gly Thr Leu Pro Met Gln Ala Pro
    50                  55                  60                  
Glu Leu Ala Val Lys Glu Met Glu Arg Cys Val Lys Glu Leu Gly Phe
65                  70                  75                  80  
Pro Gly Val Gln Ile Gly Thr His Val Asn Glu Trp Asp Leu Asn Ala
                85                  90                  95      
Gln Glu Leu Phe Pro Val Tyr Ala Ala Ala Glu Arg Leu Lys Cys Ser
            100                 105                 110         
Leu Phe Val His Pro Trp Asp Met Gln Met Asp Gly Arg Met Ala Lys
        115                 120                 125             
Tyr Trp Leu Pro Trp Leu Val Gly Met Pro Ala Glu Thr Thr Ile Ala
    130                 135                 140                 
Ile Cys Ser Met Ile Met Gly Gly Val Phe Glu Lys Phe Pro Lys Leu
145                 150                 155                 160 
Lys Val Cys Phe Ala His Gly Gly Gly Ala Phe Pro Phe Thr Val Gly
                165                 170                 175     
Arg Ile Ser His Gly Phe Ser Met Arg Pro Asp Leu Cys Ala Gln Asp
            180                 185                 190         
Asn Pro Met Asn Pro Lys Lys Tyr Leu Gly Ser Phe Tyr Thr Asp Ala
        195                 200                 205             
Leu Val His Asp Pro Leu Ser Leu Lys Leu Leu Thr Asp Val Ile Gly
    210                 215                 220                 
Lys Asp Lys Val Ile Leu Gly Thr Asp Tyr Pro Phe Pro Leu Gly Glu
225                 230                 235                 240 
Leu Glu Pro Gly Lys Leu Ile Glu Ser Met Glu Glu Phe Asp Glu Glu
                245                 250                 255     
Thr Lys Asn Lys Leu Lys Ala Gly Asn Ala Leu Ala Phe Leu Gly Leu
            260                 265                 270         
Glu Arg Lys Gln Phe Glu
        275             


<210> 2480
<211> 705
<212> PRT
<213> Homo sapiens

<400> 2480
Met Pro Leu Pro Gly Gly Leu Trp Trp Leu Leu Cys Cys Arg Arg Gly
 1               5                  10                  15      
Phe Thr Leu Leu His Arg Asp Tyr Gly Asp Gly Glu Leu Ser Gly Asp
            20                  25                  30          
Gly Asp Glu Asp Glu Asp Glu Glu Thr Phe Glu Leu Arg Thr Pro Ser
        35                  40                  45              
Pro Ala Gly Gly Gly Arg Gly Pro Leu Glu Val Thr Leu Thr Gln Pro
    50                  55                  60                  
Val Arg Ser Gly Pro Val Ser Asn Arg Leu Gln Ser Trp Glu Glu Thr
65                  70                  75                  80  
Trp Ser Leu Ile Pro Glu Lys Gly Leu Pro Glu Asp Asp Pro Asp Ile
                85                  90                  95      
Val Val Lys Gly Trp Leu Tyr Arg Glu Pro Arg Gly Gly Gly Ala Arg
            100                 105                 110         
Pro Trp Leu Pro Pro Arg Arg Ala Trp Phe Val Leu Thr Arg Asp Ser
        115                 120                 125             
Leu Asp Gln Phe Ser Ser Ser Gly Lys Gly Ala Arg Arg Leu Gly Ser
    130                 135                 140                 
Leu Val Leu Thr Ser Leu Cys Ser Val Thr Gly Pro Glu Arg Arg Arg
145                 150                 155                 160 
Lys Glu Thr Gly Leu Trp Ser Val Thr Val Ser Gly Arg Lys His Ser
                165                 170                 175     
Val Arg Leu Cys Ser Pro Arg Gln Ala Glu Ala Glu Arg Trp Gly Val
            180                 185                 190         
Ala Leu Arg Glu Val Ile Ala Ser Lys Ala Pro Leu Glu Thr Pro Thr
        195                 200                 205             
Gln Leu Leu Leu Arg Asp Ile Gln Glu Ser Cys Gly Asp Pro Glu Ala
    210                 215                 220                 
Val Ala Leu Ile Tyr Leu Arg Asn Pro Ile Leu Arg His Thr Ser Gly
225                 230                 235                 240 
Ala Leu Tyr Ala Pro Leu Leu Pro Leu Pro Tyr Gly Val Ser Ala Pro
                245                 250                 255     
Gly Pro Gly Tyr Ala Pro Leu Arg Glu Glu Ala Val Arg Leu Phe Leu
            260                 265                 270         
Ala Leu Gln Ala Leu Glu Gly Ala Arg Arg Pro Gly Pro Leu Met Gln
        275                 280                 285             
Gly Val Leu Gln Thr Cys Arg Asp Leu Pro Ala Leu Arg Asp Glu Leu
    290                 295                 300                 
Phe Leu Gln Leu Ala Lys Gln Thr Ser Gly Pro Ala Gly Pro Pro Gly
305                 310                 315                 320 
Leu Pro Ala Thr Gln Asp Pro Ala Ala Leu Arg Tyr Trp Gln Leu Leu
                325                 330                 335     
Thr Cys Met Ser Cys Thr Phe Arg Pro Gly Gly Ala Val Arg Gly His
            340                 345                 350         
Leu Leu Gly His Leu Glu Arg Thr Glu Gln Ala Leu Pro Asp Ser Glu
        355                 360                 365             
Leu Ala Glu Tyr Ala Arg Phe Ile Arg Lys Ala Leu Gly Arg Thr Arg
    370                 375                 380                 
Gly Arg Glu Leu Val Pro Ser Leu Ala Glu Ile Ser Ala Leu Ser Gln
385                 390                 395                 400 
Arg Gln Glu Leu Leu Cys Thr Val His Cys Pro Gly Ala Gly Ala Cys
                405                 410                 415     
Ala Val Ala Ile Asp Ser His Thr Thr Ala Gly Glu Val Ala Arg Glu
            420                 425                 430         
Leu Val Gly Arg Leu Gly Leu Ala Arg Ser Arg Asn Ala Phe Ala Leu
        435                 440                 445             
Tyr Glu Gln Arg Gly Ala Gln Glu Arg Ala Leu Ala Gly Gly Thr Leu
    450                 455                 460                 
Val Ala Asp Val Leu Thr Arg Phe Glu Asn Leu Ala Ala Glu Glu Ala
465                 470                 475                 480 
Gly Leu Glu Asp Ser Pro Asp Ser Gly Trp Arg Leu Cys Leu Arg Leu
                485                 490                 495     
His Gly Pro Leu His Pro Glu Gly Leu Ser Pro Asp Gly His Glu Leu
            500                 505                 510         
Pro Phe Leu Phe Glu Gln Ala His Ala Leu Leu Leu Arg Gly Arg Pro
        515                 520                 525             
Pro Pro Pro Asp Asp Thr Leu Arg Ala Leu Ala Ala Leu Arg Leu Gln
    530                 535                 540                 
Ser Leu His Arg Asp Phe Ser Pro Arg Val Pro Leu Pro Arg Leu Asp
545                 550                 555                 560 
Arg Leu Leu Pro Pro Pro Ala Pro Pro Arg Glu Asp Pro Pro Arg Pro
                565                 570                 575     
Thr Pro Arg Pro Pro Pro Ser Ala Ala Leu Leu Ala Gly Ala Leu Trp
            580                 585                 590         
Ser Pro Gly Leu Ala Lys Arg Arg Ala Glu Arg Ala Arg Arg Gly Gly
        595                 600                 605             
Ala Gly Arg Thr Ala Gly Ser Ile Ala Arg Glu Gly Gly Gly Gly Ala
    610                 615                 620                 
Gly Thr Ala Ala Ala Val Leu Gly Gly Trp Lys Arg Leu Arg Gly Met
625                 630                 635                 640 
Gly Arg Ala Glu Ala Met Ala Ala Tyr Leu Ala Leu Ala Ala Gln Cys
                645                 650                 655     
Pro Gly Phe Gly Ala Ala Arg Ser Leu Val Gly Val Leu His Arg Ser
            660                 665                 670         
Cys Ala Trp Ala Trp Glu Pro Arg Pro Cys Pro Ser Pro Gly Gln Gly
        675                 680                 685             
Arg Arg Ser Pro Ser Thr Val Ser Ala Met Ala Met Trp Pro Pro Ala
    690                 695                 700                 
Ser
705 


<210> 2481
<211> 434
<212> PRT
<213> Homo sapiens

<400> 2481
Met Leu Arg Cys Leu Tyr His Trp His Arg Pro Val Leu Asn Arg Arg
 1               5                  10                  15      
Trp Ser Arg Leu Cys Leu Leu Lys Gln Tyr Leu Phe Thr Met Lys Leu
            20                  25                  30          
Gln Ser Pro Glu Phe Gln Ser Leu Phe Thr Glu Gly Leu Lys Ser Leu
        35                  40                  45              
Thr Glu Leu Phe Val Lys Glu Asn His Glu Leu Arg Ile Ala Gly Gly
    50                  55                  60                  
Ala Val Arg Asp Leu Leu Asn Gly Val Lys Pro Gln Asp Ile Asp Phe
65                  70                  75                  80  
Ala Thr Thr Ala Thr Pro Thr Gln Met Lys Glu Met Phe Gln Ser Ala
                85                  90                  95      
Gly Ile Arg Met Ile Asn Asn Arg Gly Glu Lys His Gly Thr Ile Thr
            100                 105                 110         
Ala Arg Leu His Glu Glu Asn Phe Glu Ile Thr Thr Leu Arg Ile Asp
        115                 120                 125             
Val Thr Thr Asp Gly Arg His Ala Glu Val Glu Phe Thr Thr Asp Trp
    130                 135                 140                 
Gln Lys Asp Ala Glu Arg Arg Asp Leu Thr Ile Asn Ser Met Phe Leu
145                 150                 155                 160 
Gly Phe Asp Gly Thr Leu Phe Asp Tyr Phe Asn Gly Tyr Glu Asp Leu
                165                 170                 175     
Lys Asn Lys Lys Val Arg Phe Val Gly His Ala Lys Gln Arg Ile Gln
            180                 185                 190         
Glu Asp Tyr Leu Arg Ile Leu Arg Tyr Phe Arg Phe Tyr Gly Arg Ile
        195                 200                 205             
Val Asp Lys Pro Gly Asp His Asp Pro Glu Thr Leu Glu Ala Ile Ala
    210                 215                 220                 
Glu Asn Ala Lys Gly Leu Ala Gly Ile Ser Gly Glu Arg Ile Trp Val
225                 230                 235                 240 
Glu Leu Lys Lys Ile Leu Val Gly Asn His Val Asn His Leu Ile His
                245                 250                 255     
Leu Ile Tyr Asp Leu Asp Val Ala Pro Tyr Ile Gly Leu Pro Ala Asn
            260                 265                 270         
Ala Ser Leu Glu Glu Phe Asp Lys Val Ser Lys Asn Val Asp Gly Phe
        275                 280                 285             
Ser Pro Lys Pro Val Thr Leu Leu Ala Ser Leu Phe Lys Val Gln Asp
    290                 295                 300                 
Asp Val Thr Lys Leu Asp Leu Arg Leu Lys Ile Ala Lys Glu Glu Lys
305                 310                 315                 320 
Asn Leu Gly Leu Phe Ile Val Lys Asn Arg Lys Asp Leu Ile Lys Ala
                325                 330                 335     
Thr Asp Ser Ser Asp Pro Leu Lys Pro Tyr Gln Asp Phe Ile Ile Asp
            340                 345                 350         
Ser Arg Glu Pro Asp Ala Thr Thr Arg Val Cys Glu Leu Leu Lys Tyr
        355                 360                 365             
Gln Gly Glu His Cys Leu Leu Lys Glu Met Gln Gln Trp Ser Ile Pro
    370                 375                 380                 
Pro Phe Pro Val Ser Gly His Asp Ile Arg Lys Val Gly Ile Ser Ser
385                 390                 395                 400 
Gly Lys Glu Ile Gly Ala Leu Leu Gln Gln Leu Arg Glu Gln Trp Lys
                405                 410                 415     
Lys Ser Gly Tyr Gln Met Glu Lys Asp Glu Leu Leu Ser Tyr Ile Lys
            420                 425                 430         
Lys Thr
        


<210> 2482
<211> 52
<212> PRT
<213> Homo sapiens

<400> 2482
Met Thr Asp Thr Glu Asn His Asp Ser Ala Pro Ser Ser Thr Ser Thr
 1               5                  10                  15      
Cys Cys Pro Pro Ile Thr Ala Gly Met Gln Leu Lys Asp Ser Leu Gly
            20                  25                  30          
Pro Gly Ser Asn Arg Pro Leu Trp Thr Leu Arg Pro Leu His Leu Arg
        35                  40                  45              
Val Val Cys Leu
    50          


<210> 2483
<211> 640
<212> PRT
<213> Homo sapiens

<400> 2483
Met Gly Glu Arg Thr Leu His Ala Ala Val Pro Thr Pro Gly Tyr Pro
 1               5                  10                  15      
Glu Ser Glu Ser Ile Met Met Ala Pro Ile Cys Leu Val Glu Asn Gln
            20                  25                  30          
Glu Glu Gln Leu Thr Val Asn Ser Lys Ala Leu Glu Ile Leu Asp Lys
        35                  40                  45              
Ile Ser Gln Pro Val Val Val Val Ala Ile Val Gly Leu Tyr Arg Thr
    50                  55                  60                  
Gly Lys Ser Tyr Leu Met Asn Arg Leu Ala Gly Lys Arg Asn Gly Phe
65                  70                  75                  80  
Pro Leu Gly Ser Thr Val Gln Ser Glu Thr Lys Gly Ile Trp Met Trp
                85                  90                  95      
Cys Val Pro His Leu Ser Lys Pro Asn His Thr Leu Val Leu Leu Asp
            100                 105                 110         
Thr Glu Gly Leu Gly Asp Val Glu Lys Ser Asn Pro Lys Asn Asp Ser
        115                 120                 125             
Trp Ile Phe Ala Leu Ala Val Leu Leu Ser Ser Ser Phe Val Tyr Asn
    130                 135                 140                 
Ser Val Ser Thr Ile Asn His Gln Ala Leu Glu Gln Leu His Tyr Val
145                 150                 155                 160 
Thr Glu Leu Ala Glu Leu Ile Arg Ala Lys Ser Cys Pro Arg Pro Asp
                165                 170                 175     
Glu Ala Glu Asp Ser Ser Glu Phe Ala Ser Phe Phe Pro Asp Phe Ile
            180                 185                 190         
Trp Thr Val Arg Asp Phe Thr Leu Glu Leu Lys Leu Asp Gly Asn Pro
        195                 200                 205             
Ile Thr Glu Asp Glu Tyr Leu Glu Asn Ala Leu Lys Leu Ile Pro Gly
    210                 215                 220                 
Lys Asn Pro Lys Ile Gln Asn Ser Asn Met Pro Arg Glu Cys Ile Arg
225                 230                 235                 240 
His Phe Phe Arg Lys Arg Lys Cys Phe Val Phe Asp Arg Pro Thr Asn
                245                 250                 255     
Asp Lys Gln Tyr Leu Asn His Met Asp Glu Val Pro Glu Glu Asn Leu
            260                 265                 270         
Glu Arg His Phe Leu Met Gln Ser Asp Asn Phe Cys Ser Tyr Ile Phe
        275                 280                 285             
Thr His Ala Lys Thr Lys Thr Leu Arg Glu Gly Ile Ile Val Thr Gly
    290                 295                 300                 
Lys Arg Leu Gly Thr Leu Val Val Thr Tyr Val Asp Ala Ile Asn Ser
305                 310                 315                 320 
Gly Ala Val Pro Cys Leu Glu Asn Ala Val Thr Ala Leu Ala Gln Leu
                325                 330                 335     
Glu Asn Pro Ala Ala Val Gln Arg Ala Ala Asp His Tyr Ser Gln Gln
            340                 345                 350         
Met Ala Gln Gln Leu Arg Leu Pro Thr Asp Thr Leu Gln Glu Leu Leu
        355                 360                 365             
Asp Val His Ala Ala Cys Glu Arg Glu Ala Ile Ala Val Phe Met Glu
    370                 375                 380                 
His Ser Phe Lys Asp Glu Asn His Glu Phe Gln Lys Lys Leu Val Asp
385                 390                 395                 400 
Thr Ile Glu Lys Lys Lys Gly Asp Phe Val Leu Gln Asn Glu Glu Ala
                405                 410                 415     
Ser Ala Lys Tyr Cys Gln Ala Glu Leu Lys Arg Leu Ser Glu His Leu
            420                 425                 430         
Thr Glu Ser Ile Leu Arg Gly Ile Phe Ser Val Pro Gly Gly His Asn
        435                 440                 445             
Leu Tyr Leu Glu Glu Lys Lys Gln Val Glu Trp Asp Tyr Lys Leu Val
    450                 455                 460                 
Pro Arg Lys Gly Val Lys Ala Asn Glu Val Leu Gln Asn Phe Leu Gln
465                 470                 475                 480 
Ser Gln Val Val Val Glu Glu Ser Ile Leu Gln Ser Asp Lys Ala Leu
                485                 490                 495     
Thr Ala Gly Glu Lys Ala Ile Ala Ala Glu Arg Ala Met Lys Glu Ala
            500                 505                 510         
Ala Glu Lys Glu Gln Glu Leu Leu Arg Glu Lys Gln Lys Glu Gln Gln
        515                 520                 525             
Gln Met Met Glu Ala Gln Glu Arg Ser Phe Gln Glu Asn Ile Ala Gln
    530                 535                 540                 
Leu Lys Lys Lys Met Glu Arg Glu Arg Glu Asn Leu Leu Arg Glu His
545                 550                 555                 560 
Glu Arg Leu Leu Lys His Lys Leu Lys Val Gln Glu Glu Met Leu Lys
                565                 570                 575     
Glu Glu Phe Gln Lys Lys Ser Glu Gln Leu Asn Lys Glu Ile Asn Gln
            580                 585                 590         
Leu Lys Glu Lys Ile Glu Ser Thr Lys Asn Glu Gln Leu Arg Leu Leu
        595                 600                 605             
Lys Ile Leu Asp Met Ala Ser Asn Ile Met Ile Val Thr Leu Pro Gly
    610                 615                 620                 
Ala Ser Lys Leu Leu Gly Val Gly Thr Lys Tyr Leu Gly Ser Arg Ile
625                 630                 635                 640 


<210> 2484
<211> 472
<212> PRT
<213> Homo sapiens

<400> 2484
Met Lys Cys Lys Ala Tyr Thr Asp Cys Leu Ser Gln Asn Leu Val Val
 1               5                  10                  15      
Ile Lys Pro Gly Thr Lys Glu Thr Asp Asn Val Cys Gly Thr Leu Pro
            20                  25                  30          
Ser Phe Ser Ser Ser Thr Ser Pro Ser Pro Gly Thr Ala Ile Phe Pro
        35                  40                  45              
Arg Pro Glu His Met Glu Thr His Glu Val Pro Ser Ser Thr Tyr Val
    50                  55                  60                  
Pro Lys Gly Met Asn Ser Thr Glu Ser Asn Ser Ser Ala Ser Val Arg
65                  70                  75                  80  
Pro Lys Val Leu Ser Ser Ile Gln Glu Gly Thr Val Pro Asp Asn Thr
                85                  90                  95      
Ser Ser Ala Arg Gly Lys Glu Asp Val Asn Lys Thr Leu Pro Asn Leu
            100                 105                 110         
Gln Val Val Asn His Gln Gln Gly Pro His His Arg His Ile Leu Lys
        115                 120                 125             
Leu Leu Pro Ser Met Glu Ala Thr Gly Gly Glu Lys Ser Ser Thr Pro
    130                 135                 140                 
Ile Lys Gly Pro Lys Arg Gly His Pro Arg Gln Asn Leu His Lys His
145                 150                 155                 160 
Phe Asp Ile Asn Glu His Leu Pro Trp Met Ile Val Leu Phe Leu Leu
                165                 170                 175     
Leu Val Leu Val Val Ile Val Val Cys Ser Ile Arg Lys Ser Ser Arg
            180                 185                 190         
Thr Leu Lys Lys Gly Pro Arg Gln Asp Pro Ser Ala Ile Val Glu Lys
        195                 200                 205             
Ala Gly Leu Lys Lys Ser Met Thr Pro Thr Gln Asn Arg Glu Lys Trp
    210                 215                 220                 
Ile Tyr Tyr Cys Asn Gly His Gly Ile Asp Ile Leu Lys Leu Val Ala
225                 230                 235                 240 
Ala Gln Val Gly Ser Gln Trp Lys Asp Ile Tyr Gln Phe Leu Cys Asn
                245                 250                 255     
Ala Ser Glu Arg Glu Val Ala Ala Phe Ser Asn Gly Tyr Thr Ala Asp
            260                 265                 270         
His Glu Arg Ala Tyr Ala Ala Leu Gln His Trp Thr Ile Arg Gly Pro
        275                 280                 285             
Glu Ala Ser Leu Ala Gln Leu Ile Ser Ala Leu Arg Gln His Arg Arg
    290                 295                 300                 
Asn Asp Val Val Glu Lys Ile Arg Gly Leu Met Glu Asp Thr Thr Gln
305                 310                 315                 320 
Leu Glu Thr Asp Lys Leu Ala Leu Pro Met Ser Pro Ser Pro Leu Ser
                325                 330                 335     
Pro Ser Pro Ile Pro Ser Pro Asn Ala Lys Leu Glu Asn Ser Ala Leu
            340                 345                 350         
Leu Thr Val Glu Pro Ser Pro Gln Asp Lys Asn Lys Gly Phe Phe Val
        355                 360                 365             
Asp Glu Ser Glu Pro Leu Leu Arg Cys Asp Ser Thr Ser Ser Gly Ser
    370                 375                 380                 
Ser Ala Leu Ser Arg Asn Gly Ser Phe Ile Thr Lys Glu Lys Lys Asp
385                 390                 395                 400 
Thr Val Leu Arg Gln Val Arg Leu Asp Pro Cys Asp Leu Gln Pro Ile
                405                 410                 415     
Phe Asp Asp Met Leu His Phe Leu Asn Pro Glu Glu Leu Arg Val Ile
            420                 425                 430         
Glu Glu Ile Pro Gln Ala Glu Asp Lys Leu Asp Arg Leu Phe Glu Ile
        435                 440                 445             
Ile Gly Val Lys Ser Gln Glu Ala Ser Gln Thr Leu Leu Asp Ser Val
    450                 455                 460                 
Tyr Ser His Leu Pro Asp Leu Leu
465                 470         


<210> 2485
<211> 234
<212> PRT
<213> Homo sapiens

<400> 2485
Met Ala Phe Leu Ala Gly Pro Arg Leu Leu Asp Trp Ala Ser Ser Pro
 1               5                  10                  15      
Pro His Leu Gln Phe Asn Lys Phe Val Leu Thr Gly Tyr Arg Pro Ala
            20                  25                  30          
Ser Ser Gly Ser Gly Cys Leu Arg Ser Leu Phe Tyr Leu His Asn Glu
        35                  40                  45              
Leu Gly Asn Ile Tyr Thr His Gly Ser Val Leu Tyr His Leu Phe Met
    50                  55                  60                  
Cys His Gln Gly Gly Ser Ala Val Tyr Ala Arg Leu Leu Ala Leu Asp
65                  70                  75                  80  
Met Cys Gly Val Cys Leu Val Asn Thr Leu Gly Ala Leu Pro Ile Ile
                85                  90                  95      
His Cys Thr Leu Ala Cys Arg Pro Trp Leu Arg Pro Ala Ala Leu Val
            100                 105                 110         
Gly Tyr Thr Val Leu Ser Gly Val Ala Gly Trp Arg Ala Leu Thr Ala
        115                 120                 125             
Pro Ser Thr Ser Ala Arg Leu Arg Ala Phe Gly Trp Gln Ala Ala Ala
    130                 135                 140                 
Arg Leu Leu Val Phe Glu Ala Arg Gly Val Gly Leu Gly Ser Gly Ala
145                 150                 155                 160 
Pro Gly Ser Leu Pro Cys Tyr Leu Arg Met Asp Ala Leu Ala Leu Leu
                165                 170                 175     
Gly Gly Leu Val Asn Val Ala Arg Leu Pro Glu Arg Trp Gly Pro Gly
            180                 185                 190         
Arg Phe Asp Tyr Trp Gly Asn Ser His Gln Ile Met His Leu Leu Ser
        195                 200                 205             
Val Gly Ser Ile Leu Gln Leu His Ala Gly Val Val Pro Asp Leu Leu
    210                 215                 220                 
Trp Ala Ala His His Ala Cys Pro Arg Asp
225                 230                 


<210> 2486
<211> 411
<212> PRT
<213> Homo sapiens

<400> 2486
Met Gln Val Glu Glu Ala Thr Gly Gln Ala Ala Gly Arg Arg Arg Gly
 1               5                  10                  15      
Asn Val Val Arg Arg Val Phe Gly Arg Ile Arg Arg Phe Phe Ser Arg
            20                  25                  30          
Arg Arg Asn Glu Pro Thr Leu Pro Arg Glu Phe Thr Arg Arg Gly Arg
        35                  40                  45              
Arg Gly Ala Val Ser Val Asp Ser Leu Ala Glu Leu Glu Asp Gly Ala
    50                  55                  60                  
Leu Leu Leu Gln Thr Leu Gln Leu Ser Lys Ile Ser Phe Pro Ile Gly
65                  70                  75                  80  
Gln Arg Leu Leu Gly Ser Lys Arg Lys Met Ser Leu Asn Pro Ile Ala
                85                  90                  95      
Lys Gln Ile Pro Gln Val Val Glu Ala Cys Cys Gln Phe Ile Glu Lys
            100                 105                 110         
His Gly Leu Ser Ala Val Gly Ile Phe Thr Leu Glu Tyr Ser Val Gln
        115                 120                 125             
Arg Val Arg Gln Leu Arg Glu Glu Phe Asp Gln Gly Leu Asp Val Val
    130                 135                 140                 
Leu Asp Asp Asn Gln Asn Val His Asp Val Ala Ala Leu Leu Lys Glu
145                 150                 155                 160 
Phe Phe Arg Asp Met Lys Asp Ser Leu Leu Pro Asp Asp Leu Tyr Met
                165                 170                 175     
Ser Phe Leu Leu Thr Ala Thr Leu Lys Pro Gln Asp Gln Leu Ser Ala
            180                 185                 190         
Leu Gln Leu Leu Val Tyr Leu Met Pro Pro Cys His Ser Asp Thr Leu
        195                 200                 205             
Glu Arg Leu Leu Lys Ala Leu His Lys Ile Thr Glu Asn Cys Glu Asp
    210                 215                 220                 
Ser Ile Gly Ile Asp Gly Gln Leu Val Pro Gly Asn Arg Met Thr Ser
225                 230                 235                 240 
Thr Asn Leu Ala Leu Val Phe Gly Ser Ala Leu Leu Lys Lys Gly Lys
                245                 250                 255     
Phe Gly Lys Arg Glu Ser Arg Lys Thr Lys Leu Gly Ile Asp His Tyr
            260                 265                 270         
Val Ala Ser Val Asn Val Val Arg Ala Met Ile Asp Asn Trp Asp Val
        275                 280                 285             
Leu Phe Gln Val Pro Pro His Ile Gln Arg Gln Val Ala Lys Arg Val
    290                 295                 300                 
Trp Lys Ser Ser Pro Glu Ala Leu Asp Phe Ile Arg Arg Arg Asn Leu
305                 310                 315                 320 
Arg Lys Ile Gln Ser Ala Arg Ile Lys Met Glu Glu Asp Ala Leu Leu
                325                 330                 335     
Ser Asp Pro Val Glu Thr Ser Ala Glu Ala Arg Ala Ala Val Leu Ala
            340                 345                 350         
Gln Ser Lys Pro Ser Asp Glu Gly Ser Ser Glu Glu Pro Ala Val Pro
        355                 360                 365             
Ser Gly Thr Ala Arg Ser His Asp Asp Glu Glu Gly Ala Gly Asn Pro
    370                 375                 380                 
Pro Ile Pro Glu Gln Asp Arg Pro Leu Leu Arg Val Pro Arg Glu Lys
385                 390                 395                 400 
Glu Ala Lys Thr Gly Val Ser Tyr Phe Phe Pro
                405                 410     


<210> 2487
<211> 372
<212> PRT
<213> Homo sapiens

<400> 2487
Met Ser Thr Ala Ala Leu Ile Thr Leu Val Arg Ser Gly Gly Asn Gln
 1               5                  10                  15      
Val Arg Arg Arg Val Leu Leu Ser Ser Arg Leu Leu Gln Asp Asp Arg
            20                  25                  30          
Arg Val Thr Pro Thr Cys His Ser Ser Thr Ser Glu Pro Arg Cys Ser
        35                  40                  45              
Arg Phe Asp Pro Asp Gly Ser Gly Ser Pro Ala Thr Trp Asp Asn Phe
    50                  55                  60                  
Gly Ile Trp Asp Asn Arg Ile Asp Glu Pro Ile Leu Leu Pro Pro Ser
65                  70                  75                  80  
Ile Lys Tyr Gly Lys Pro Ile Pro Lys Ile Ser Leu Glu Asn Val Gly
                85                  90                  95      
Cys Ala Ser Gln Ile Gly Lys Arg Lys Glu Asn Glu Asp Arg Phe Asp
            100                 105                 110         
Phe Ala Gln Leu Thr Asp Glu Val Leu Tyr Phe Ala Val Tyr Asp Gly
        115                 120                 125             
His Gly Gly Pro Ala Ala Ala Asp Phe Cys His Thr His Met Glu Lys
    130                 135                 140                 
Cys Ile Met Asp Leu Leu Pro Lys Glu Lys Asn Leu Glu Thr Leu Leu
145                 150                 155                 160 
Thr Leu Ala Phe Leu Glu Ile Asp Lys Ala Phe Ser Ser His Ala Arg
                165                 170                 175     
Leu Ser Ala Asp Ala Thr Leu Leu Thr Ser Gly Thr Thr Ala Thr Val
            180                 185                 190         
Ala Leu Leu Arg Asp Gly Ile Glu Leu Val Val Ala Ser Val Gly Asp
        195                 200                 205             
Ser Arg Ala Ile Leu Cys Arg Lys Gly Lys Pro Met Lys Leu Thr Ile
    210                 215                 220                 
Asp His Thr Pro Glu Arg Lys Asp Glu Lys Glu Arg Ile Lys Lys Cys
225                 230                 235                 240 
Gly Gly Phe Val Ala Trp Asn Ser Leu Gly Gln Pro His Val Asn Gly
                245                 250                 255     
Arg Leu Ala Met Thr Arg Ser Val Gly Asp Leu Asp Leu Lys Thr Ser
            260                 265                 270         
Gly Val Ile Ala Glu Pro Glu Thr Lys Arg Ile Lys Leu His His Ala
        275                 280                 285             
Asp Asp Ser Phe Leu Val Leu Thr Thr Asp Gly Ile Asn Phe Met Val
    290                 295                 300                 
Asn Ser Gln Glu Ile Cys Asp Phe Val Asn Gln Cys His Asp Pro Asn
305                 310                 315                 320 
Glu Ala Ala His Ala Val Thr Glu Gln Ala Ile Gln Tyr Gly Thr Glu
                325                 330                 335     
Asp Asn Ser Thr Ala Val Val Val Pro Phe Gly Ala Trp Gly Lys Tyr
            340                 345                 350         
Lys Asn Ser Glu Ile Asn Phe Ser Phe Ser Arg Ser Phe Ala Ser Ser
        355                 360                 365             
Gly Arg Trp Ala
    370         


<210> 2488
<211> 539
<212> PRT
<213> Homo sapiens

<400> 2488
Met Ser Leu Ser Asp Lys Gln Thr Ala Ser Leu Thr Ala Ala Tyr Gly
 1               5                  10                  15      
Gln Leu Ser Lys Gly Lys Pro Ala Glu Cys Arg Met Asp Ser Pro Lys
            20                  25                  30          
Glu Ile Ser Gln Ala Gly Phe Glu Trp Gln Arg Thr Glu Gly Lys Leu
        35                  40                  45              
Asn Glu Ile Gly Leu Asn Val Ser Met Asp Gly Gln Pro Lys Asp Gly
    50                  55                  60                  
Leu Val Lys Asn Ala Ser Phe Leu Glu Gln Asn Lys Leu Cys Phe Phe
65                  70                  75                  80  
Glu Gly Lys Leu Asp Lys Glu Leu Ser Ile Glu Met Gln Asp Lys Asp
                85                  90                  95      
Cys Gln Glu Ala Ser Gly His Leu Glu Ser Arg Tyr Val Ile Ser Glu
            100                 105                 110         
Thr Cys His Pro Leu Glu Gly Asn Ser Val His Gln Lys Thr Ser Glu
        115                 120                 125             
Phe His Leu Gly Leu Ile Glu Gly Pro Asp Lys Asn Lys Thr Ile Pro
    130                 135                 140                 
Val Gln Gly Lys Val Ala Gly Lys Asn Gly Leu Glu Thr Lys Ser Gln
145                 150                 155                 160 
Ser Asp Leu Asp Phe Pro Gly Ala Ala Asp Ile Pro Thr Arg Tyr Val
                165                 170                 175     
Lys Glu Gln Glu Thr Ser Val Trp Asn Pro Ser Phe His Pro Val Ala
            180                 185                 190         
Gln Gly Ser Leu Gly Ser Arg Glu Ala Thr Pro Gly Glu Met Glu Asn
        195                 200                 205             
Ser Ile Thr Pro Gly Cys Pro Val Ile Gly Val Val Asn Asp Asn Ser
    210                 215                 220                 
Glu Gln Leu Lys Cys Glu Ser Pro Leu Leu Val Ser Leu Ala His Pro
225                 230                 235                 240 
Ala Pro Ile Ile Glu His Ser Pro Thr Thr Ile Pro Pro Ile Thr Met
                245                 250                 255     
Val Phe Thr Gln Glu His Leu Asn Ala Ser Cys His Ile Arg Asp His
            260                 265                 270         
Asp Lys Glu Leu Glu Lys Leu Ser Ser Thr Glu Glu Ala Val Leu Asn
        275                 280                 285             
Gln Ala Pro Gln Gln Lys Lys Ala Val Arg Arg Ala Leu Ser Glu Cys
    290                 295                 300                 
Ser His Leu Ser Val Pro Pro Ala Val Asn Leu Ala Asp Lys Tyr Pro
305                 310                 315                 320 
Glu Leu Pro Ala Arg Glu Glu Pro Ser Ser Gly Leu Leu Pro Pro Pro
                325                 330                 335     
Ser Ser Pro Met Pro Ser Pro Thr Pro Gly Lys Leu Gly Ala Pro Ala
            340                 345                 350         
Met Lys Arg Ser Met Thr Val Gly Glu Glu Gln Thr Ala Ser Tyr Lys
        355                 360                 365             
Leu Ser Pro Gly Lys Leu Pro Ile Leu Ser Thr Lys Glu Ile Pro Pro
    370                 375                 380                 
Phe Ile Cys Glu Glu Pro Val Ala Lys Lys Arg Glu Glu Leu Ala His
385                 390                 395                 400 
Phe Ser Asn Ser Ser Ser Asn Ser Gly Lys Lys Glu Leu Gly Thr Ala
                405                 410                 415     
Gly Leu Tyr Leu His Ser Lys Leu Glu Gln Ile Pro Glu Gly Ser Ser
            420                 425                 430         
Lys Glu Lys Gly Gln Glu Asp Phe Ser Glu Thr Arg Ile Asp Ser Cys
        435                 440                 445             
Ser Gln Val Cys Gln Arg Gly Glu Lys Gln Pro Gly Gln Thr Ala Leu
    450                 455                 460                 
Ala Gly Lys Lys Glu Ile Glu Val Thr Ala Thr Gln Ser Thr Pro Ser
465                 470                 475                 480 
Phe Leu Phe Glu Lys Pro Pro Arg Asp Gly Ile Ala Arg Pro Glu Glu
                485                 490                 495     
Gly Arg Pro Val Val Ser Gly Thr Gly Asn Asp Ile Thr Thr Pro Pro
            500                 505                 510         
Asn Lys Glu Leu Pro Pro Ser Pro Glu Lys Lys Thr Lys Val Gly Ala
        515                 520                 525             
Arg Met Val Val Ile Phe Tyr Cys His Asn Phe
    530                 535                 


<210> 2489
<211> 135
<212> PRT
<213> Homo sapiens

<400> 2489
Met Phe Arg Pro Phe Val Glu Val Cys Ile Leu Gly Pro Asn Leu Gly
 1               5                  10                  15      
Asp Lys Lys Arg Lys Gln Gly Thr Lys Thr Lys Ser Asn Thr Trp Ser
            20                  25                  30          
Pro Lys Tyr Asn Glu Thr Phe Gln Phe Ile Leu Gly Lys Glu Asn Arg
        35                  40                  45              
Pro Gly Ala Tyr Glu Leu His Leu Ser Val Lys Asp Tyr Cys Phe Ala
    50                  55                  60                  
Arg Glu Asp Arg Ile Ile Gly Met Thr Val Ile Gln Leu Gln Asn Ile
65                  70                  75                  80  
Ala Glu Lys Gly Ser Tyr Gly Ala Trp Tyr Pro Leu Leu Lys Asn Ile
                85                  90                  95      
Ser Met Asp Glu Thr Gly Leu Thr Ile Leu Arg Ile Leu Ser Gln Arg
            100                 105                 110         
Thr Ser Asp Asp Val Ala Lys Glu Phe Val Arg Leu Lys Ser Glu Thr
        115                 120                 125             
Arg Ser Thr Glu Glu Ser Ala
    130                 135 


<210> 2490
<211> 811
<212> PRT
<213> Homo sapiens

<400> 2490
Met Glu Thr Ser Ser Met Leu Ser Ser Leu Asn Asp Glu Cys Lys Ser
 1               5                  10                  15      
Asp Asn Tyr Ile Glu Pro His Tyr Lys Glu Trp Tyr Arg Val Ala Ile
            20                  25                  30          
Asp Ile Leu Ile Glu His Gly Leu Glu Ala Tyr Gln Glu Phe Leu Val
        35                  40                  45              
Gln Glu Arg Val Ser Asp Phe Leu Ala Glu Glu Glu Ile Asn Tyr Ile
    50                  55                  60                  
Leu Lys Asn Val Gln Lys Val Ala Gln Ser Thr Ala His Gly Thr Asp
65                  70                  75                  80  
Asp Ser Cys Asp Asp Thr Leu Ser Ser Gly Thr Tyr Trp Pro Val Glu
                85                  90                  95      
Ser Asp Val Glu Ala Pro Asn Leu Asp Leu Gly Trp Pro Tyr Val Met
            100                 105                 110         
Pro Gly Leu Leu Gly Gly Thr His Ile Asp Leu Leu Phe His Pro Pro
        115                 120                 125             
Arg Ala His Leu Leu Thr Ile Lys Glu Thr Ile Arg Lys Met Ile Lys
    130                 135                 140                 
Glu Ala Arg Lys Val Ile Ala Leu Val Met Asp Ile Phe Thr Asp Val
145                 150                 155                 160 
Asp Ile Phe Lys Glu Ile Val Glu Ala Ser Thr Arg Gly Val Ser Val
                165                 170                 175     
Tyr Ile Leu Leu Asp Glu Ser Asn Phe Asn His Phe Leu Asn Met Thr
            180                 185                 190         
Glu Lys Gln Gly Cys Ser Val Gln Arg Leu Arg Asn Ile Arg Val Arg
        195                 200                 205             
Thr Val Lys Gly Gln Asp Tyr Leu Ser Lys Thr Gly Ala Lys Phe His
    210                 215                 220                 
Gly Lys Met Glu Gln Lys Phe Leu Leu Val Asp Cys Gln Lys Val Met
225                 230                 235                 240 
Tyr Gly Ser Tyr Ser Tyr Met Trp Ser Phe Glu Lys Ala His Leu Ser
                245                 250                 255     
Met Val Gln Ile Ile Thr Gly Gln Leu Val Glu Ser Phe Asp Glu Glu
            260                 265                 270         
Phe Arg Thr Leu Tyr Ala Arg Ser Cys Val Pro Ser Ser Phe Ala Gln
        275                 280                 285             
Glu Glu Ser Ala Arg Val Lys His Gly Lys Ala Leu Trp Glu Asn Gly
    290                 295                 300                 
Thr Tyr Gln His Ser Val Ser Ser Leu Ala Ser Val Ser Ser Gln Arg
305                 310                 315                 320 
Asn Leu Phe Gly Arg Gln Asp Lys Ile His Lys Leu Asp Ser Ser Tyr
                325                 330                 335     
Phe Lys Asn Arg Gly Ile Tyr Thr Leu Asn Glu His Gly Lys Tyr Asn
            340                 345                 350         
Ile Arg Ser His Gly Tyr Lys Pro His Phe Val Pro Asn Phe Asn Gly
        355                 360                 365             
Pro Asn Ala Ile Arg Gln Phe Gln Pro Asn Gln Ile Asn Glu Asn Trp
    370                 375                 380                 
Lys Arg His Ser Tyr Ala Gly Glu Gln Pro Glu Thr Val Pro Tyr Leu
385                 390                 395                 400 
Leu Leu Asn Arg Ala Leu Asn Arg Thr Asn Asn Pro Pro Gly Asn Trp
                405                 410                 415     
Glu Lys Pro Ser Asp Ser Leu Ser Val Ala Ser Ser Ser Arg Glu Gly
            420                 425                 430         
Tyr Val Ser His His Asn Thr Pro Ala Gln Ser Phe Ala Asn Arg Leu
        435                 440                 445             
Ala Gln Arg Lys Thr Thr Asn Leu Ala Asp Arg Asn Ser Asn Val Arg
    450                 455                 460                 
Arg Ser Phe Asn Gly Thr Asp Asn His Ile Arg Phe Leu Gln Gln Arg
465                 470                 475                 480 
Met Pro Thr Leu Glu His Thr Thr Lys Ser Phe Leu Arg Asn Trp Arg
                485                 490                 495     
Ile Glu Ser Tyr Leu Asn Asp His Ser Glu Ala Thr Pro Asp Ser Asn
            500                 505                 510         
Gly Ser Ala Leu Gly Asp Arg Phe Glu Gly Tyr Asp Asn Pro Glu Asn
        515                 520                 525             
Leu Lys Ala Asn Ala Leu Tyr Thr His Ser Arg Leu Ser Ser Ser Leu
    530                 535                 540                 
Val Phe Lys Pro Thr Leu Pro Glu Gln Lys Glu Val Asn Ser Cys Thr
545                 550                 555                 560 
Thr Gly Ser Ser Asn Ser Thr Ile Ile Gly Ser Gln Gly Ser Glu Thr
                565                 570                 575     
Pro Lys Glu Val Pro Asp Thr Pro Thr Asn Val Gln His Leu Thr Asp
            580                 585                 590         
Lys Pro Leu Pro Glu Ser Ile Pro Lys Leu Pro Leu Gln Ser Glu Ala
        595                 600                 605             
Pro Lys Met His Thr Leu Gln Val Pro Glu Asn His Ser Val Ala Leu
    610                 615                 620                 
Asn Gln Thr Thr Asn Gly His Thr Glu Ser Asn Asn Tyr Ile Tyr Lys
625                 630                 635                 640 
Thr Leu Gly Val Asn Lys Gln Thr Glu Asn Leu Lys Asn Gln Gln Thr
                645                 650                 655     
Glu Asn Leu Leu Lys Arg Arg Ser Phe Pro Leu Phe Asp Asn Ser Lys
            660                 665                 670         
Ala Asn Leu Asp Pro Gly Asn Ser Lys His Tyr Val Tyr Ser Thr Leu
        675                 680                 685             
Thr Arg Asn Arg Val Arg Gln Pro Glu Lys Pro Lys Glu Asp Leu Leu
    690                 695                 700                 
Lys Ser Ser Lys Ser Met His Asn Val Thr His Asn Leu Glu Glu Asp
705                 710                 715                 720 
Glu Glu Glu Val Thr Lys Arg Asn Ser Pro Ser Gly Thr Thr Thr Lys
                725                 730                 735     
Ser Val Ser Ile Ala Ala Leu Leu Asp Val Asn Lys Glu Glu Ser Asn
            740                 745                 750         
Lys Glu Leu Ala Ser Lys Lys Glu Val Lys Gly Ser Pro Ser Phe Leu
        755                 760                 765             
Lys Lys Gly Ser Gln Lys Leu Arg Ser Leu Leu Ser Leu Thr Pro Asp
    770                 775                 780                 
Lys Lys Glu Asn Leu Ser Lys Asn Lys Ala Pro Ala Phe Tyr Arg Leu
785                 790                 795                 800 
Cys Ser Ser Ser Asp Thr Leu Val Ser Glu Gly
                805                 810     


<210> 2491
<211> 473
<212> PRT
<213> Homo sapiens

<400> 2491
Met Ala Ser Arg Ser Leu Gly Gly Leu Ser Gly Ile Arg Gly Gly Gly
 1               5                  10                  15      
Gly Gly Gly Gly Lys Lys Ser Leu Ser Ala Arg Asn Ala Ala Val Glu
            20                  25                  30          
Arg Arg Asn Leu Ile Thr Val Cys Arg Phe Ser Val Lys Thr Leu Ile
        35                  40                  45              
Asp Arg Ser Cys Phe Glu Thr Ile Asp Asp Ser Ser Pro Glu Phe Asn
    50                  55                  60                  
Asn Phe Ala Ala Ile Leu Glu Gln Ile Leu Ser His Arg Leu Lys Glu
65                  70                  75                  80  
Ile Ser Gln Ser Cys Arg Trp Leu Ala His Leu Gln Ile Pro Leu Gln
                85                  90                  95      
Gly Gln Val Thr Trp Phe Gly Tyr Glu Ser Pro Arg Ser Phe Trp Asp
            100                 105                 110         
Tyr Ile Arg Val Ala Cys Arg Lys Val Ser Gln Asn Cys Ile Cys Ser
        115                 120                 125             
Ile Glu Asn Met Glu Asn Val Ser Ser Ser Arg Ala Lys Gly Arg Ala
    130                 135                 140                 
Trp Ile Arg Val Ala Leu Met Glu Lys His Leu Ser Glu Tyr Ile Ser
145                 150                 155                 160 
Thr Ala Leu Arg Asp Phe Lys Thr Thr Arg Arg Phe Tyr Glu Asp Gly
                165                 170                 175     
Ala Ile Val Leu Gly Glu Glu Ala Asn Met Leu Ala Gly Met Leu Leu
            180                 185                 190         
Gly Leu Asn Ala Ile Asp Phe Ser Phe Cys Leu Lys Gly Glu Gly Leu
        195                 200                 205             
Asp Gly Ser Phe Pro Ala Val Ile Asp Tyr Thr Pro Tyr Leu Lys Tyr
    210                 215                 220                 
Ile Gln Ser Ser Asp Ser Ile Ser Ser Asp Glu Glu Glu Leu Arg Thr
225                 230                 235                 240 
Leu Gly Ser Ser Gly Ser Glu Ser Ser Thr Pro Glu Asn Val Gly Pro
                245                 250                 255     
Pro Phe Leu Met Asp Glu Asn Ser Trp Phe Asn Lys Cys Lys Arg Val
            260                 265                 270         
Lys Gln Lys Tyr Gln Leu Thr Leu Glu Gln Lys Gly Tyr Leu Glu Glu
        275                 280                 285             
Leu Leu Arg Leu Arg Glu Asn Gln Leu Ser Glu Ser Val Ser Gln Asn
    290                 295                 300                 
Lys Ile Leu Leu Gln Arg Ile Glu Asp Ser Asp Leu Ala His Lys Leu
305                 310                 315                 320 
Glu Lys Glu Gln Leu Glu Tyr Ile Ile Val Glu Leu Gln Asp Gln Leu
                325                 330                 335     
Thr Val Leu Lys Asn Asn Asp Leu Arg Ser Arg Gln Glu Leu Thr Ala
            340                 345                 350         
His Leu Thr Asn Gln Trp Pro Ser Pro Gly Ala Leu Asp Val Asn Ala
        355                 360                 365             
Val Ala Leu Asp Thr Leu Leu Tyr Arg Lys His Asn Lys Gln Trp Tyr
    370                 375                 380                 
Glu Lys Ser Tyr Gln Ser Leu Asp Gln Leu Ser Ala Glu Val Ser Leu
385                 390                 395                 400 
Ser Gln Thr Ser Leu Asp Pro Gly Gln Ser Gln Glu Gly Asp Gly Lys
                405                 410                 415     
Gln Asp Thr Leu Asn Val Met Ser Glu Gly Lys Glu Asp Thr Pro Ser
            420                 425                 430         
Leu Leu Gly Leu Cys Gly Ser Leu Thr Ser Val Ala Ser Tyr Lys Ser
        435                 440                 445             
Leu Thr Ser Leu Lys Ser Asn Asp Tyr Leu Ala Ser Pro Thr Thr Glu
    450                 455                 460                 
Met Thr Ser Pro Gly Leu Thr Pro Ser
465                 470             


<210> 2492
<211> 272
<212> PRT
<213> Homo sapiens

<400> 2492
Met Gln Trp Asn Val Pro Arg Thr Val Ser Arg Leu Ala Arg Arg Thr
 1               5                  10                  15      
Cys Leu Glu Pro His Asn Ala Gly Leu Phe Gly His Cys Gln Asn Val
            20                  25                  30          
Lys Gly Pro Leu Leu Leu Tyr Asn Ala Glu Ser Lys Val Val Leu Val
        35                  40                  45              
Arg Gly Pro Gln Lys Gln Trp Leu His Leu Ser Ala Ala Gln Cys Val
    50                  55                  60                  
Ala Lys Glu Arg Arg Pro Leu Asp Ala His Pro Pro Gln Pro Gly Val
65                  70                  75                  80  
Leu Arg His Lys Gln Gly Lys Gln His Val Ser Phe Arg Arg Val Phe
                85                  90                  95      
Ser Ser Ser Ala Thr Ala Gln Gly Thr Pro Glu Lys Lys Glu Glu Pro
            100                 105                 110         
Asp Pro Leu Gln Asp Lys Ser Ile Ser Leu Tyr Gln Arg Phe Lys Lys
        115                 120                 125             
Thr Phe Arg Gln Tyr Gly Lys Val Leu Ile Pro Val His Leu Ile Thr
    130                 135                 140                 
Ser Gly Val Trp Phe Gly Thr Phe Tyr Tyr Ala Ala Leu Lys Gly Val
145                 150                 155                 160 
Asn Val Val Pro Phe Leu Glu Leu Ile Gly Leu Pro Asp Ser Val Val
                165                 170                 175     
Ser Ile Leu Lys Asn Ser Gln Ser Gly Asn Ala Leu Thr Ala Tyr Ala
            180                 185                 190         
Leu Phe Lys Ile Ala Thr Pro Ala Arg Tyr Thr Val Thr Leu Gly Gly
        195                 200                 205             
Thr Ser Val Thr Val Lys Tyr Leu Arg Ser His Gly Tyr Met Ser Thr
    210                 215                 220                 
Pro Pro Pro Val Lys Glu Tyr Leu Gln Asp Arg Met Glu Glu Thr Lys
225                 230                 235                 240 
Glu Leu Ile Thr Glu Lys Met Glu Glu Thr Lys Asp Arg Leu Thr Glu
                245                 250                 255     
Lys Leu Gln Glu Thr Lys Glu Lys Val Ser Phe Lys Lys Lys Val Glu
            260                 265                 270         


<210> 2493
<211> 295
<212> PRT
<213> Homo sapiens

<400> 2493
Met Arg His Ser Val Ala Arg Pro Thr Arg Leu Pro Arg Arg Leu Ser
 1               5                  10                  15      
Pro Phe Trp Asp Pro Ala Thr Cys Lys Asn Leu Glu Gly Gly Ala Gly
            20                  25                  30          
Glu Val Val Arg Gly Arg Asp Pro Arg Arg Leu Arg Thr Ser Arg Ser
        35                  40                  45              
Thr Glu Ile Leu Gly Glu Gly Leu Ala Gly Pro Ser Ala Gly Ala Ala
    50                  55                  60                  
Ala Arg Pro Ala Ala Pro Pro Pro Gln Pro Arg Glu Pro Gly Ala Pro
65                  70                  75                  80  
Gly Leu Arg Arg Ala Pro Pro Arg Thr Arg Met Asp Ser Ser Gly Leu
                85                  90                  95      
Gly Pro Cys Ser Glu Ala Pro Leu His Thr Ser Ala Gly Leu Ser Gly
            100                 105                 110         
Arg Asn Leu Arg Ala Ala Gly Gly Val Leu Pro Val Asp Leu Glu Arg
        115                 120                 125             
Glu Arg Ala Ala Leu Cys Ala Arg Gln Ser Gly His Gly Pro Pro Ala
    130                 135                 140                 
Val Arg Trp Leu Leu Gly Ser Arg Gly Ala Glu Ser Gly Gly Leu Ala
145                 150                 155                 160 
Arg Arg Arg Val Ala Ala Glu His Ala Gln Pro Ser Ala Asn Leu Val
                165                 170                 175     
Cys Arg Ser Ala Leu Glu Thr Ser Ala Phe Pro Pro Ser Lys Pro Lys
            180                 185                 190         
Ser Pro Arg Gly Arg Val Arg Ala Arg Ser Ser Asp Gly Arg Leu Arg
        195                 200                 205             
His Pro Ala Trp Arg Ala Gly Ser Gly Gly Arg Gly Gly Arg Gly Pro
    210                 215                 220                 
Ser Ala Glu Leu Ala Ser Arg Tyr Trp Gly Arg Arg Arg Ala Leu Pro
225                 230                 235                 240 
Gly Ala Ala Asp Leu Arg Pro Lys Gly Ala Arg Ala Asp Asp Arg Arg
                245                 250                 255     
Pro Leu Arg Ala Gly Arg Lys Leu His Leu Pro Glu Ala Ala Arg Leu
            260                 265                 270         
Pro Gly Asn Val Gly Lys Ser Gly Glu Pro His Lys Ala Gly Glu Val
        275                 280                 285             
Gly Asn His Pro Arg Asp Ser
    290                 295 


<210> 2494
<211> 532
<212> PRT
<213> Homo sapiens

<400> 2494
Met Ala Pro Ser Phe Thr Ala Arg Ile Gln Leu Phe Leu Leu Arg Ala
 1               5                  10                  15      
Leu Gly Phe Leu Ile Gly Leu Val Gly Arg Ala Ala Leu Val Leu Gly
            20                  25                  30          
Gly Pro Lys Phe Ala Ser Lys Thr Pro Arg Pro Val Thr Glu Pro Leu
        35                  40                  45              
Leu Leu Leu Ser Gly Met Gln Leu Ala Lys Leu Ile Arg Gln Arg Lys
    50                  55                  60                  
Val Lys Cys Ile Asp Val Val Gln Ala Tyr Ile Asn Arg Ile Lys Asp
65                  70                  75                  80  
Val Asn Pro Met Ile Asn Gly Ile Val Lys Tyr Arg Phe Glu Glu Ala
                85                  90                  95      
Met Arg Glu Ala His Ala Val Asp Gln Lys Leu Ala Glu Lys Gln Glu
            100                 105                 110         
Asp Glu Ala Thr Leu Glu Asn Lys Trp Pro Phe Leu Gly Val Pro Leu
        115                 120                 125             
Thr Val Lys Glu Ala Phe Gln Leu Gln Gly Met Pro Asn Ser Ser Gly
    130                 135                 140                 
Leu Met Asn Arg Arg Asp Ala Ile Ala Lys Thr Asp Ala Thr Val Val
145                 150                 155                 160 
Ala Leu Leu Lys Gly Ala Gly Ala Ile Pro Leu Gly Ile Thr Asn Cys
                165                 170                 175     
Ser Glu Leu Cys Met Trp Tyr Glu Ser Ser Asn Lys Ile Tyr Gly Arg
            180                 185                 190         
Ser Asn Asn Pro Tyr Asp Leu Gln His Ile Val Gly Gly Ser Ser Gly
        195                 200                 205             
Gly Glu Gly Cys Thr Leu Ala Ala Ala Cys Ser Val Ile Gly Val Gly
    210                 215                 220                 
Ser Asp Ile Gly Gly Ser Ile Arg Met Pro Ala Phe Phe Asn Gly Ile
225                 230                 235                 240 
Phe Gly His Lys Pro Ser Pro Gly Val Val Pro Asn Lys Gly Gln Phe
                245                 250                 255     
Pro Leu Ala Val Gly Ala Gln Glu Leu Phe Leu Cys Thr Gly Pro Met
            260                 265                 270         
Cys Arg Tyr Ala Glu Asp Leu Ala Pro Met Leu Lys Val Met Ala Gly
        275                 280                 285             
Pro Gly Ile Lys Arg Leu Lys Leu Asp Thr Lys Val His Leu Lys Asp
    290                 295                 300                 
Leu Lys Phe Tyr Trp Met Glu His Asp Gly Gly Ser Phe Leu Met Ser
305                 310                 315                 320 
Lys Val Asp Gln Asp Leu Ile Met Thr Gln Lys Lys Val Val Val His
                325                 330                 335     
Leu Glu Thr Ile Leu Gly Ala Ser Val Gln His Val Lys Leu Lys Lys
            340                 345                 350         
Met Lys Tyr Ser Phe Gln Leu Trp Ile Ala Met Met Ser Ala Lys Gly
        355                 360                 365             
His Asp Gly Lys Glu Pro Val Lys Phe Val Asp Leu Leu Gly Asp His
    370                 375                 380                 
Gly Lys His Val Ser Pro Leu Trp Glu Leu Ile Lys Trp Cys Leu Gly
385                 390                 395                 400 
Leu Ser Val Tyr Thr Ile Pro Ser Ile Gly Leu Ala Leu Leu Glu Glu
                405                 410                 415     
Lys Leu Arg Tyr Ser Asn Glu Lys Tyr Gln Lys Phe Lys Ala Val Glu
            420                 425                 430         
Glu Ser Leu Arg Lys Glu Leu Val Asp Met Leu Gly Asp Asp Gly Val
        435                 440                 445             
Phe Leu Tyr Pro Ser His Pro Thr Val Ala Pro Lys His His Val Pro
    450                 455                 460                 
Leu Thr Arg Pro Phe Asn Phe Ala Tyr Thr Gly Val Phe Ser Ala Leu
465                 470                 475                 480 
Gly Leu Pro Val Thr Gln Cys Pro Leu Gly Leu Asn Ala Lys Gly Leu
                485                 490                 495     
Pro Leu Gly Ile Gln Val Val Ala Gly Pro Phe Asn Asp His Leu Thr
            500                 505                 510         
Leu Ala Val Ala Gln Tyr Leu Glu Lys Thr Phe Gly Gly Trp Val Cys
        515                 520                 525             
Pro Gly Lys Phe
    530         


<210> 2495
<211> 380
<212> PRT
<213> Homo sapiens

<400> 2495
Met Ala Glu Ala Met Lys Leu Gln Lys Met Lys Leu Met Ala Met Asn
 1               5                  10                  15      
Thr Leu Gln Gly Asn Gly Ser Gln Asn Gly Thr Glu Ser Glu Pro Asp
            20                  25                  30          
Asp Leu Asn Ser Asn Thr Gly Gly Ser Glu Ser Ser Trp Asp Lys Asp
        35                  40                  45              
Lys Met Gln Ser Pro Phe Ala Ala Pro Gly Pro Gln His Gly Ile Ala
    50                  55                  60                  
His Ala Ala Leu Ala Gly Gln Pro Gly Ile Gly Gly Ala Pro Thr Leu
65                  70                  75                  80  
Asn Pro Leu Gln Gln Asn His Leu Leu Thr Asn Arg Leu Asp Leu Pro
                85                  90                  95      
Phe Met Met Met Pro His Pro Leu Leu Pro Val Ser Leu Pro Pro Ala
            100                 105                 110         
Ser Val Ala Met Ala Met Asn Gln Met Asn His Leu Asn Thr Ile Ala
        115                 120                 125             
Asn Met Ala Ala Ala Ala Gln Ile His Ser Pro Leu Ser Arg Ala Gly
    130                 135                 140                 
Thr Ser Val Ile Lys Glu Arg Ile Pro Glu Ser Pro Ser Pro Ala Pro
145                 150                 155                 160 
Ser Leu Glu Glu Asn His Arg Pro Gly Ser Gln Thr Ser Ser His Thr
                165                 170                 175     
Ser Ser Ser Val Ser Ser Ser Pro Ser Gln Met Asp His His Leu Glu
            180                 185                 190         
Arg Met Glu Glu Val Pro Val Gln Ile Pro Ile Met Lys Ser Pro Leu
        195                 200                 205             
Asp Lys Ile Gln Leu Thr Pro Gly Gln Ala Leu Pro Ala Gly Phe Pro
    210                 215                 220                 
Gly Pro Phe Ile Phe Ala Asp Ser Leu Ser Ser Val Glu Thr Leu Leu
225                 230                 235                 240 
Thr Asn Ile Gln Gly Leu Leu Lys Val Ala Leu Asp Asn Ala Arg Ile
                245                 250                 255     
Gln Glu Lys Gln Ile Gln Gln Glu Lys Lys Glu Leu Arg Leu Glu Leu
            260                 265                 270         
Tyr Arg Glu Arg Glu Ile Arg Glu Asn Leu Glu Arg Gln Leu Ala Val
        275                 280                 285             
Glu Leu Gln Ser Arg Thr Thr Met Gln Lys Arg Leu Lys Lys Glu Lys
    290                 295                 300                 
Lys Thr Lys Arg Lys Leu Gln Glu Ala Leu Glu Phe Glu Ser Lys Arg
305                 310                 315                 320 
Arg Glu Gln Val Glu Gln Ala Leu Lys Gln Ala Thr Thr Ser Asp Ser
                325                 330                 335     
Gly Leu Arg Met Leu Lys Asp Thr Gly Ile Pro Asp Ile Glu Ile Glu
            340                 345                 350         
Asn Asn Gly Thr Pro His Asp Ser Ala Ala Met Gln Gly Gly Asn Tyr
        355                 360                 365             
Tyr Cys Leu Glu Met Ala Gln Gln Leu Tyr Ser Ala
    370                 375                 380 


<210> 2496
<211> 710
<212> PRT
<213> Homo sapiens

<400> 2496
Met Ser Ser Gln Gln Phe Pro Arg Leu Gly Ala Pro Ser Thr Gly Leu
 1               5                  10                  15      
Ser Gln Ala Pro Ser Gln Ile Ala Asn Ser Gly Ser Ala Gly Leu Ile
            20                  25                  30          
Asn Pro Ala Ala Thr Val Asn Asp Glu Ser Gly Arg Asp Ser Glu Val
        35                  40                  45              
Ser Ala Arg Glu His Met Ser Ser Ser Ser Ser Leu Gln Ser Arg Glu
    50                  55                  60                  
Glu Lys Gln Glu Pro Val Val Val Arg Pro Tyr Pro Gln Val Gln Met
65                  70                  75                  80  
Leu Ser Thr His His Ala Val Ala Ser Ala Thr Pro Val Ala Val Thr
                85                  90                  95      
Ala Pro Pro Ala His Leu Thr Pro Ala Val Pro Leu Ser Phe Ser Glu
            100                 105                 110         
Gly Leu Met Lys Pro Pro Pro Lys Pro Thr Met Pro Ser Arg Pro Ile
        115                 120                 125             
Ala Pro Ala Pro Pro Ser Thr Leu Ser Leu Pro Pro Lys Val Pro Gly
    130                 135                 140                 
Gln Val Thr Val Thr Met Glu Ser Ser Ile Pro Gln Ala Ser Ala Ile
145                 150                 155                 160 
Pro Val Ala Thr Ile Ser Gly Gln Gln Gly His Pro Ser Asn Leu His
                165                 170                 175     
His Ile Met Thr Thr Asn Val Gln Met Ser Ile Ile Arg Ser Asn Ala
            180                 185                 190         
Pro Gly Pro Pro Leu His Ile Gly Ala Ser His Leu Pro Arg Gly Ala
        195                 200                 205             
Ala Ala Ala Ala Val Met Ser Ser Ser Lys Val Thr Thr Val Leu Arg
    210                 215                 220                 
Pro Thr Ser Gln Leu Pro Asn Ala Ala Thr Ala Gln Pro Ala Val Gln
225                 230                 235                 240 
His Ile Ile His Gln Pro Ile Gln Ser Arg Pro Pro Val Thr Thr Ser
                245                 250                 255     
Asn Ala Ile Pro Pro Ala Val Val Ala Thr Val Ser Ala Thr Arg Ala
            260                 265                 270         
Gln Ser Pro Val Ile Thr Thr Thr Ala Ala His Ala Thr Asp Ser Ala
        275                 280                 285             
Leu Arg Pro Thr Leu Ser Ile Gln His Pro Pro Ser Ala Ala Ile Ser
    290                 295                 300                 
Ile Gln Arg Pro Ala Gln Ser Arg Asp Val Thr Thr Arg Ile Thr Leu
305                 310                 315                 320 
Pro Ser His Pro Ala Leu Gly Thr Pro Lys Gln Gln Leu His Thr Met
                325                 330                 335     
Ala Gln Lys Thr Ile Phe Ser Thr Gly Thr Pro Val Ala Ala Ala Thr
            340                 345                 350         
Val Ala Pro Ile Leu Ala Thr Asn Thr Ile Pro Ser Ala Thr Thr Ala
        355                 360                 365             
Gly Ser Val Ser His Thr Gln Ala Pro Thr Ser Thr Ile Val Thr Met
    370                 375                 380                 
Thr Val Pro Ser His Ser Ser His Ala Thr Ala Val Thr Thr Ser Asn
385                 390                 395                 400 
Ile Pro Val Ala Lys Val Val Pro Gln Gln Ile Thr His Thr Ser Pro
                405                 410                 415     
Arg Ile Gln Pro Asp Tyr Pro Ala Glu Arg Ser Ser Leu Ile Pro Ile
            420                 425                 430         
Ser Gly His Arg Ala Ser Pro Asn Pro Val Ala Met Glu Thr Arg Ser
        435                 440                 445             
Asp Asn Arg Pro Ser Val Pro Val Gln Phe Gln Tyr Phe Leu Pro Thr
    450                 455                 460                 
Tyr Pro Pro Ser Ala Tyr Pro Leu Ala Ala His Thr Tyr Thr Pro Ile
465                 470                 475                 480 
Thr Ser Ser Val Ser Thr Ile Arg Gln Tyr Pro Val Ser Ala Gln Ala
                485                 490                 495     
Pro Asn Ser Ala Ile Thr Ala Gln Thr Gly Val Gly Val Ala Ser Thr
            500                 505                 510         
Val His Leu Asn Pro Met Gln Leu Met Thr Val Asp Ala Ser His Ala
        515                 520                 525             
Arg His Ile Gln Gly Ile Gln Pro Ala Pro Ile Ser Thr Gln Gly Ile
    530                 535                 540                 
Gln Pro Ala Pro Ile Gly Thr Pro Gly Ile Gln Pro Ala Pro Leu Gly
545                 550                 555                 560 
Thr Gln Gly Ile His Ser Ala Thr Pro Ile Asn Thr Gln Gly Leu Gln
                565                 570                 575     
Pro Ala Pro Met Gly Thr Gln Gln Pro Gln Pro Glu Gly Lys Thr Ser
            580                 585                 590         
Ala Val Val Leu Ala Asp Gly Ala Thr Ile Val Ala Asn Pro Ile Ser
        595                 600                 605             
Asn Pro Phe Ser Ala Ala Pro Ala Ala Thr Thr Val Val Gln Thr His
    610                 615                 620                 
Ser Gln Ser Ala Ser Thr Asn Ala Pro Ala Gln Gly Ser Ser Pro Arg
625                 630                 635                 640 
Pro Ser Ile Leu Arg Lys Lys Pro Ala Thr Asp Gly Met Ala Val Arg
                645                 650                 655     
Lys Thr Leu Ile Pro Pro Gln Pro Pro Asp Val Ala Ser Pro Arg Val
            660                 665                 670         
Glu Ser Ser Met Arg Ser Thr Ser Gly Ser Pro Arg Pro Ala Gly Ala
        675                 680                 685             
Lys Pro Lys Ser Glu Ile His Val Ser Met Ala Thr Pro Val Thr Val
    690                 695                 700                 
Ser Met Glu Thr Val Ser
705                 710 


<210> 2497
<211> 202
<212> PRT
<213> Homo sapiens

<400> 2497
Met Ala Pro Leu Gly Asp Leu Ala Ala Glu Ser Gln Pro Ser Leu Gly
 1               5                  10                  15      
Arg Gly Val Val Val Ala Ile Val Arg Ala Asp Arg Ser Pro Arg Leu
            20                  25                  30          
Gly Glu Gly Gly Pro Ala Ala Glu Val Tyr Lys Arg Met Lys Val Gly
        35                  40                  45              
Arg Arg Gly Val Pro Ala Ala Ser Arg Thr Pro Ala Ser Phe Thr Cys
    50                  55                  60                  
His Glu His His Glu Asp Arg Ala Ala Pro Phe Gly Arg Arg Asp Gly
65                  70                  75                  80  
Gly Arg Asn Gly Ala Leu Glu Pro Gln His Arg Ser Leu Arg Ala Gln
                85                  90                  95      
Ala Leu Ala Arg Cys Val Val Ser Ala Val Pro Lys Pro Ala Pro Pro
            100                 105                 110         
Ser Val Phe Val Arg Leu Cys Gly Pro Arg Asn Leu Gly Trp Phe Gly
        115                 120                 125             
Pro His Leu Arg Leu Arg Thr Ser Ala His Ala Arg Gln Arg His Pro
    130                 135                 140                 
Glu Thr Arg Ala Ser Ala Arg Glu Asn Thr Ser Arg His Ser Arg Asn
145                 150                 155                 160 
Pro Ser Val Ser Val Pro Gln Asp Leu Leu Ser Leu Ala Ser Arg Trp
                165                 170                 175     
Cys Gly Arg Ala Pro Ala Arg Pro Pro Val Ala Gln Ser Arg Lys Trp
            180                 185                 190         
Arg Lys Ala Val Arg Gly Met Thr Asn Arg
        195                 200         


<210> 2498
<211> 676
<212> PRT
<213> Homo sapiens

<400> 2498
Met Gln Gly Thr Val Ala Phe Glu Asp Val Ala Val Asn Phe Ser Gln
 1               5                  10                  15      
Glu Glu Trp Ser Leu Leu Ser Glu Val Gln Arg Cys Leu Tyr His Asp
            20                  25                  30          
Val Met Leu Glu Asn Trp Val Leu Ile Ser Ser Leu Gly Cys Trp Cys
        35                  40                  45              
Gly Ser Glu Asp Glu Glu Ala Pro Ser Lys Lys Ser Ile Ser Ile Gln
    50                  55                  60                  
Arg Val Ser Gln Val Ser Thr Pro Gly Ala Gly Val Ser Pro Lys Lys
65                  70                  75                  80  
Ala His Ser Cys Glu Met Cys Gly Ala Ile Leu Gly Asp Ile Leu His
                85                  90                  95      
Leu Ala Asp His Gln Gly Thr His His Lys Gln Lys Leu His Arg Cys
            100                 105                 110         
Glu Ala Trp Gly Asn Lys Leu Tyr Asp Ser Ser Asn Arg Pro His Gln
        115                 120                 125             
Asn Gln Tyr Leu Gly Glu Lys Pro Tyr Arg Ser Ser Val Glu Glu Ala
    130                 135                 140                 
Leu Phe Val Lys Arg Cys Lys Phe His Val Ser Glu Glu Ser Ser Ile
145                 150                 155                 160 
Phe Ile Gln Ser Gly Lys Asp Phe Leu Pro Ser Ser Gly Leu Leu Leu
                165                 170                 175     
Gln Glu Ala Thr His Thr Gly Glu Lys Ser Asn Ser Lys Pro Glu Cys
            180                 185                 190         
Glu Ser Pro Phe Gln Trp Gly Asp Thr His Tyr Ser Cys Gly Glu Cys
        195                 200                 205             
Met Lys His Ser Ser Thr Lys His Val Phe Val Gln Gln Gln Arg Leu
    210                 215                 220                 
Pro Ser Arg Glu Glu Cys Tyr Cys Trp Glu Cys Gly Lys Ser Phe Ser
225                 230                 235                 240 
Lys Tyr Asp Ser Val Ser Asn His Gln Arg Val His Thr Gly Lys Arg
                245                 250                 255     
Pro Tyr Glu Cys Gly Glu Cys Gly Lys Ser Phe Ser His Lys Gly Ser
            260                 265                 270         
Leu Val Gln His Gln Arg Val His Thr Gly Lys Arg Pro Tyr Glu Cys
        275                 280                 285             
Gly Gly Cys Gly Lys Ser Phe Ser His Lys Gly Ser Leu Val Gln His
    290                 295                 300                 
Gln Arg Val His Thr Gly Glu Arg Pro Tyr Glu Cys Gly Glu Cys Gly
305                 310                 315                 320 
Lys Ser Phe Ser Gln Asn Gly Thr Leu Ile Lys His Gln Arg Val His
                325                 330                 335     
Thr Gly Glu Arg Pro Tyr Glu Cys Glu Glu Cys Gly Lys Cys Phe Thr
            340                 345                 350         
Gln Lys Gly Asn Leu Ile Gln His Gln Arg Gly His Thr Ser Glu Arg
        355                 360                 365             
Pro Tyr Glu Cys Glu Glu Cys Gly Lys Cys Phe Ser Gln Lys Gly Thr
    370                 375                 380                 
Leu Thr Glu His His Arg Val His Thr Arg Glu Arg Pro Tyr Glu Cys
385                 390                 395                 400 
Gly Glu Cys Gly Lys Ser Phe Ser Arg Lys Gly His Leu Arg Asn His
                405                 410                 415     
Gln Arg Gly His Thr Gly Glu Arg Pro Tyr Glu Cys Gly Glu Cys Gly
            420                 425                 430         
Lys Ser Phe Ser Arg Lys Gly Asn Leu Ile Gln His Gln Arg Ser His
        435                 440                 445             
Thr Gly Glu Arg Pro Tyr Glu Cys Arg Glu Cys Arg Lys Leu Phe Arg
    450                 455                 460                 
Gly Lys Ser His Leu Ile Glu His Gln Arg Val His Thr Gly Glu Arg
465                 470                 475                 480 
Pro Tyr Glu Cys Asn Glu Cys Gly Lys Ser Phe Gln Asp Ser Ser Gly
                485                 490                 495     
Phe Arg Val His Gln Arg Val His Thr Gly Glu Lys Pro Phe Glu Cys
            500                 505                 510         
Ser Glu Cys Gly Lys Ser Phe Pro Gln Ser Cys Ser Leu Leu Arg His
        515                 520                 525             
Arg Arg Val His Thr Gly Glu Arg Pro Tyr Glu Cys Gly Glu Cys Gly
    530                 535                 540                 
Lys Ser Phe His Gln Ser Ser Ser Leu Leu Arg His Gln Lys Thr His
545                 550                 555                 560 
Thr Ala Glu Arg Pro Tyr Glu Cys Arg Glu Cys Gly Lys Phe Phe Ser
                565                 570                 575     
Ser Leu Leu Glu His Arg Arg Val His Thr Gly Glu Arg Pro Tyr Glu
            580                 585                 590         
Cys Arg Glu Cys Gly Lys Thr Phe Thr Arg Arg Ser Ala His Phe Lys
        595                 600                 605             
His Gln Arg Leu His Thr Arg Gly Lys Pro Tyr Glu Cys Ser Glu Cys
    610                 615                 620                 
Gly Lys Ser Phe Ala Glu Thr Phe Ser Leu Thr Glu His Arg Arg Val
625                 630                 635                 640 
His Thr Gly Glu Arg Pro Tyr Glu Cys Ser Glu Cys Gly Lys Ser Phe
                645                 650                 655     
His Arg Ser Ser Ser Leu Leu Arg His Gln Arg Val His Thr Glu Arg
            660                 665                 670         
Ser Pro Tyr Lys
        675     


<210> 2499
<211> 760
<212> PRT
<213> Homo sapiens

<400> 2499
Met Ile Ile Thr Glu Asp Ser Leu Pro Ser Leu Glu Ala Ile Leu Asn
 1               5                  10                  15      
Tyr Ser Ile Phe Asn Arg Glu Asn Asp Leu Leu Ala Gln Phe Asp Ala
            20                  25                  30          
Ile Pro Gly Lys Lys Gly Thr Arg Val Leu Ile Trp Asn Ile Arg Arg
        35                  40                  45              
Asn Lys Asn Gly Lys Ser Glu Leu Asp Phe Asp Thr Asp Gln Tyr Asp
    50                  55                  60                  
Ile Leu Val Ser Asp Phe Asp Thr Glu Glu Lys Met Thr Gly Gly Val
65                  70                  75                  80  
Thr Ser Glu Leu Pro Glu Thr Glu Tyr Ser Leu Arg Ala Phe Cys Gly
                85                  90                  95      
Ile Leu Tyr Met Lys Pro Arg Met Lys Ile Phe Leu Arg Gln Lys Lys
            100                 105                 110         
Val Thr Thr Gln Met Ile Ala Lys Ser Leu Ala Asn Val Glu Tyr Asp
        115                 120                 125             
Thr His Lys Pro Thr Phe Thr Asn Lys Gln Val Arg Ile Thr Phe Gly
    130                 135                 140                 
Phe Ser Cys Lys Asn Ser Asn Gln Phe Gly Ile Met Met Tyr His Asn
145                 150                 155                 160 
Asn Arg Leu Ile Lys Ser Phe Glu Lys Val Gly Cys Gln Val Lys Pro
                165                 170                 175     
Thr Arg Gly Glu Gly Val Gly Val Ile Gly Val Ile Glu Cys Asn Phe
            180                 185                 190         
Leu Lys Pro Ala Tyr Asn Lys Gln Asp Phe Glu Tyr Thr Lys Glu Tyr
        195                 200                 205             
Arg Leu Thr Ile Asn Ala Leu Ala Gln Lys Leu Asn Ala Tyr Trp Lys
    210                 215                 220                 
Glu Lys Thr Ser Gln Asp Asn Phe Glu Thr Ser Thr Val Ala Arg Pro
225                 230                 235                 240 
Ile Pro Lys Val Pro Asp Gln Thr Trp Val Gln Cys Asp Glu Cys Leu
                245                 250                 255     
Lys Trp Arg Lys Leu Pro Gly Lys Ile Asp Pro Ser Met Leu Pro Ala
            260                 265                 270         
Arg Trp Phe Cys Tyr Tyr Asn Ser His Pro Lys Tyr Arg Arg Cys Ser
        275                 280                 285             
Val Pro Glu Glu Gln Glu Leu Ile Asp Glu Asp Leu Cys Leu Ser Lys
    290                 295                 300                 
Ala Lys Lys Gln Glu Gln Thr Val Glu Glu Lys Lys Lys Met Pro Met
305                 310                 315                 320 
Glu Asn Glu Asn His Gln Val Phe Ser Asn Pro Pro Lys Ile Leu Thr
                325                 330                 335     
Val Gln Glu Met Ala Gly Leu Asn Asn Lys Thr Ile Gly Tyr Glu Gly
            340                 345                 350         
Ile His Ser Pro Ser Val Leu Pro Ser Gly Gly Glu Glu Ser Arg Ser
        355                 360                 365             
Pro Ser Leu Gln Leu Lys Pro Leu Asp Ser Ser Val Leu Gln Phe Ser
    370                 375                 380                 
Ser Lys Tyr Lys Trp Ile Leu Gly Glu Glu Pro Val Glu Lys Arg Arg
385                 390                 395                 400 
Arg Leu Gln Asn Glu Met Thr Thr Pro Ser Leu Asp Tyr Ser Met Pro
                405                 410                 415     
Ala Pro Tyr Arg Arg Val Glu Ala Pro Val Ala Tyr Pro Glu Gly Glu
            420                 425                 430         
Asn Ser His Asp Lys Ser Ser Ser Glu Arg Ser Thr Pro Pro Tyr Leu
        435                 440                 445             
Phe Pro Glu Tyr Pro Glu Ala Ser Lys Asn Thr Gly Gln Asn Arg Glu
    450                 455                 460                 
Val Ser Ile Leu Tyr Pro Gly Ala Lys Asp Gln Arg Gln Gly Ser Leu
465                 470                 475                 480 
Leu Pro Glu Glu Leu Glu Asp Gln Met Pro Arg Leu Val Ala Glu Glu
                485                 490                 495     
Ser Asn Arg Gly Ser Thr Thr Ile Asn Lys Glu Glu Val Asn Lys Gly
            500                 505                 510         
Pro Phe Val Ala Val Val Gly Val Ala Lys Gly Val Arg Asp Ser Gly
        515                 520                 525             
Ala Pro Ile Gln Leu Ile Pro Phe Asn Arg Glu Glu Leu Ala Glu Arg
    530                 535                 540                 
Arg Lys Ala Val Glu Ser Trp Asn Pro Val Pro Tyr Ser Val Ala Ser
545                 550                 555                 560 
Ala Ala Ile Pro Ala Ala Ala Ile Gly Glu Lys Ala Arg Gly Tyr Glu
                565                 570                 575     
Glu Ser Glu Gly His Asn Thr Pro Lys Leu Lys Asn Gln Arg Glu Leu
            580                 585                 590         
Glu Glu Leu Lys Arg Thr Thr Glu Lys Leu Glu Arg Val Leu Ala Glu
        595                 600                 605             
Arg Asn Leu Phe Gln Gln Lys Val Glu Glu Leu Glu Gln Glu Arg Asn
    610                 615                 620                 
His Trp Gln Ser Glu Phe Lys Lys Val Gln His Glu Leu Val Ile Tyr
625                 630                 635                 640 
Ser Thr Gln Glu Ala Glu Gly Leu Tyr Trp Ser Lys Lys His Met Gly
                645                 650                 655     
Tyr Arg Gln Ala Glu Phe Gln Ile Leu Lys Ala Glu Leu Glu Arg Thr
            660                 665                 670         
Lys Glu Glu Lys Gln Glu Leu Lys Glu Lys Leu Lys Glu Thr Glu Thr
        675                 680                 685             
His Leu Glu Met Leu Gln Lys Ala Gln Val Ser Tyr Arg Thr Pro Glu
    690                 695                 700                 
Gly Asp Asp Leu Glu Arg Ala Leu Ala Lys Leu Thr Arg Leu Arg Ile
705                 710                 715                 720 
His Val Ser Tyr Leu Leu Thr Ser Val Leu Pro His Leu Glu Leu Arg
                725                 730                 735     
Glu Ile Gly Tyr Asp Ser Glu Gln Val Asp Gly Ile Leu Tyr Thr Val
            740                 745                 750         
Leu Glu Ala Asn His Ile Leu Asp
        755                 760 


<210> 2500
<211> 647
<212> PRT
<213> Homo sapiens

<400> 2500
Met Thr Val Gly Arg Pro Glu Gly Ala Pro Gly Gly Ala Glu Gly Ser
 1               5                  10                  15      
Arg Gln Ile Phe Pro Pro Glu Ser Phe Ala Asp Thr Glu Ala Gly Glu
            20                  25                  30          
Glu Leu Ser Gly Asp Gly Leu Val Leu Pro Arg Ala Ser Lys Leu Asp
        35                  40                  45              
Glu Phe Leu Ser Pro Glu Glu Glu Met Asp Ser Thr Ser Asp Ser Thr
    50                  55                  60                  
Gly Ser Ile Tyr Gln Asn Leu Gln Glu Leu Lys Gln Lys Gly Arg Trp
65                  70                  75                  80  
Cys Leu Leu Glu Ser Leu Phe Gln Ser Asp Pro Glu Ser Asp Glu Asn
                85                  90                  95      
Leu Ser Glu Asp Glu Glu Asp Leu Glu Ser Phe Phe Gln Asp Lys Asp
            100                 105                 110         
Arg Gly Met Val Gln Val Gln Cys Pro Gln Ala Leu Arg Cys Gly Ser
        115                 120                 125             
Thr Arg Arg Cys Ser Ser Leu Asn Asn Leu Pro Ser Asn Ile Pro Arg
    130                 135                 140                 
Pro Gln Thr Gln Pro Pro Ser Gly Ser Arg Pro Pro Ser Gln His Arg
145                 150                 155                 160 
Ser Val Ser Ser Trp Ala Ser Ser Ile Thr Val Pro Arg Pro Phe Arg
                165                 170                 175     
Met Thr Leu Arg Glu Ala Arg Lys Lys Ala Glu Trp Leu Gly Ser Pro
            180                 185                 190         
Ala Ser Phe Glu Gln Glu Arg Gln Arg Ala Gln Arg Gln Gly Glu Glu
        195                 200                 205             
Glu Ala Glu Cys His Arg Gln Phe Arg Ala Gln Pro Val Pro Ala His
    210                 215                 220                 
Val Tyr Leu Pro Leu Tyr Gln Glu Ile Met Glu Arg Ser Glu Ala Arg
225                 230                 235                 240 
Arg Gln Ala Gly Ile Gln Lys Arg Lys Glu Leu Leu Leu Ser Ser Leu
                245                 250                 255     
Lys Pro Phe Ser Phe Leu Glu Lys Glu Glu Gln Leu Lys Glu Ala Ala
            260                 265                 270         
Arg Gln Arg Asp Leu Ala Ala Thr Ala Glu Ala Lys Ile Ser Lys Gln
        275                 280                 285             
Lys Ala Thr Arg Arg Ile Pro Lys Ser Ile Leu Glu Pro Ala Leu Gly
    290                 295                 300                 
Asp Lys Leu Gln Glu Ala Glu Leu Phe Arg Lys Ile Arg Ile Gln Met
305                 310                 315                 320 
Arg Ala Leu Asp Met Leu Gln Met Ala Ser Ser Pro Ile Ala Ser Ser
                325                 330                 335     
Ser Asn Arg Ala Asn Pro Gln Pro Arg Thr Ala Thr Arg Thr Gln Gln
            340                 345                 350         
Glu Lys Leu Gly Phe Leu His Thr Asn Phe Arg Phe Gln Pro Arg Val
        355                 360                 365             
Asn Pro Val Val Pro Asp Tyr Glu Gly Leu Tyr Lys Ala Phe Gln Arg
    370                 375                 380                 
Arg Ala Ala Lys Arg Arg Glu Thr Gln Glu Ala Thr Arg Asn Lys Pro
385                 390                 395                 400 
Phe Leu Leu Arg Thr Ala Asn Leu Arg His Pro Gln Arg Pro Cys Asp
                405                 410                 415     
Ala Ala Thr Thr Gly Arg Arg Gln Asp Ser Pro Gln Pro Pro Ala Thr
            420                 425                 430         
Pro Leu Pro Arg Ser Arg Ser Leu Ser Gly Leu Ala Ser Leu Ser Ala
        435                 440                 445             
Asn Thr Leu Pro Val His Ile Thr Asp Ala Thr Arg Lys Arg Glu Ser
    450                 455                 460                 
Ala Val Arg Ser Ala Leu Glu Lys Lys Asn Lys Ala Asp Glu Ser Ile
465                 470                 475                 480 
Gln Trp Leu Glu Ile His Arg Lys Lys Ser Gln Ala Met Ser Lys Ser
                485                 490                 495     
Val Thr Leu Arg Ala Lys Ala Met Asp Pro His Lys Ser Leu Glu Glu
            500                 505                 510         
Val Phe Lys Ala Lys Leu Lys Glu Asn Arg Asn Asn Asp Arg Lys Arg
        515                 520                 525             
Ala Lys Glu Tyr Lys Lys Glu Leu Glu Glu Met Lys Gln Arg Ile Gln
    530                 535                 540                 
Thr Arg Pro Tyr Leu Phe Glu Gln Val Ala Lys Asp Leu Ala Lys Lys
545                 550                 555                 560 
Glu Ala Glu Gln Trp Tyr Leu Asp Thr Leu Lys Gln Ala Gly Leu Glu
                565                 570                 575     
Glu Asp Phe Val Arg Asn Lys Gly Gln Gly Thr Arg Ala Val Gln Glu
            580                 585                 590         
Lys Glu Thr Lys Ile Lys Asp Phe Pro Arg Phe Gln Glu Thr Thr Lys
        595                 600                 605             
Leu Ser Ile Arg Asp Pro Glu Gln Gly Leu Glu Gly Ser Leu Glu Gln
    610                 615                 620                 
Pro Ala Ser Pro Arg Lys Val Leu Glu Glu Leu Ser His Gln Ser Pro
625                 630                 635                 640 
Glu Asn Leu Val Ser Leu Ala
                645         


<210> 2501
<211> 224
<212> PRT
<213> Homo sapiens

<400> 2501
Met Ala Ala Pro Ser Glu Val Ala Ala Ile Ala Pro Gly Glu Gly Asp
 1               5                  10                  15      
Gly Gly Gly Gly Gly Phe Gly Ser Trp Leu Asp Gly Arg Leu Glu Ala
            20                  25                  30          
Leu Gly Val Asp Arg Ala Val Tyr Gly Ala Tyr Ile Leu Gly Ile Leu
        35                  40                  45              
Gln Glu Glu Glu Glu Glu Glu Lys Leu Asp Ala Leu Gln Gly Ile Leu
    50                  55                  60                  
Ser Ala Phe Leu Glu Glu Asp Ser Leu Leu Asn Ile Cys Lys Glu Ile
65                  70                  75                  80  
Val Glu Arg Trp Ser Glu Thr Gln Asn Val Val Thr Lys Val Lys Lys
                85                  90                  95      
Glu Asp Glu Val Gln Ala Ile Ala Thr Leu Ile Glu Lys Gln Ala Gln
            100                 105                 110         
Ile Val Val Lys Pro Arg Met Val Ser Glu Glu Glu Lys Gln Arg Lys
        115                 120                 125             
Ala Ala Leu Leu Ala Gln Tyr Ala Asp Val Thr Asp Glu Glu Asp Glu
    130                 135                 140                 
Ala Asp Glu Lys Asp Asp Ser Gly Ala Thr Thr Met Asn Ile Gly Ser
145                 150                 155                 160 
Asp Lys Leu Leu Phe Arg Asn Thr Asn Val Glu Asp Val Phe Asn Ala
                165                 170                 175     
Arg Lys Leu Glu Arg Asp Ser Leu Arg Asp Glu Ser Gln Arg Lys Lys
            180                 185                 190         
Glu Gln Asp Lys Leu Gln Arg Glu Arg Asp Lys Leu Ala Lys Gln Glu
        195                 200                 205             
Arg Lys Glu Lys Glu Lys Lys Arg Thr Gln Arg Gly Glu Arg Lys Arg
    210                 215                 220                 


<210> 2502
<211> 266
<212> PRT
<213> Homo sapiens

<400> 2502
Met Glu Pro Gly Ala Gly Gly Arg Asn Thr Ala Arg Ala Gln Arg Ala
 1               5                  10                  15      
Gly Ser Pro Asn Thr Pro Pro Pro Arg Glu Gln Glu Arg Lys Leu Glu
            20                  25                  30          
Gln Glu Lys Leu Ser Gly Val Val Lys Ser Val His Arg Arg Leu Arg
        35                  40                  45              
Lys Lys Tyr Arg Glu Val Gly Asp Phe Asp Lys Ile Trp Arg Glu His
    50                  55                  60                  
Cys Glu Asp Glu Glu Thr Leu Cys Glu Tyr Ala Val Ala Met Lys Asn
65                  70                  75                  80  
Leu Ala Asp Asn His Trp Ala Lys Thr Cys Glu Gly Glu Gly Arg Ile
                85                  90                  95      
Glu Trp Cys Cys Ser Val Cys Arg Glu Tyr Phe Gln Asn Gly Gly Lys
            100                 105                 110         
Arg Lys Ala Leu Glu Lys Asp Glu Lys Arg Ala Val Leu Ala Thr Lys
        115                 120                 125             
Thr Thr Pro Ala Leu Asn Met His Glu Ser Ser Gln Leu Glu Gly His
    130                 135                 140                 
Leu Thr Asn Leu Ser Phe Thr Asn Pro Glu Phe Ile Thr Glu Leu Leu
145                 150                 155                 160 
Gln Ala Ser Gly Lys Ile Arg Leu Leu Asp Val Gly Ser Cys Phe Asn
                165                 170                 175     
Pro Phe Leu Lys Phe Glu Glu Phe Leu Thr Val Gly Ile Asp Ile Val
            180                 185                 190         
Pro Ala Val Glu Ser Val Tyr Lys Cys Asp Phe Leu Asn Leu Gln Leu
        195                 200                 205             
Gln Gln Pro Leu Gln Leu Ala Gln Asp Ala Thr Asp Ala Phe Leu Lys
    210                 215                 220                 
Gln Leu Lys Asn Pro Ile Asp Ser Leu Pro Gly Glu Leu Phe His Val
225                 230                 235                 240 
Val Val Phe Ser Leu Leu Leu Ser Tyr Phe Pro Ser Pro Tyr Gln Arg
                245                 250                 255     
Trp Ile Ala Ala Arg Lys Pro Met Asn Cys
            260                 265     


<210> 2503
<211> 831
<212> PRT
<213> Homo sapiens

<400> 2503
Met Pro Leu Glu Met Glu Pro Lys Met Ser Lys Leu Ala Phe Gly Cys
 1               5                  10                  15      
Gln Arg Ser Ser Thr Ser Asp Asp Asp Ser Gly Cys Ala Leu Glu Glu
            20                  25                  30          
Tyr Ala Trp Val Pro Pro Gly Leu Arg Pro Glu Gln Ile Gln Leu Tyr
        35                  40                  45              
Phe Ala Cys Leu Pro Glu Glu Lys Val Pro Tyr Val Asn Ser Pro Gly
    50                  55                  60                  
Glu Lys His Arg Ile Lys Gln Leu Leu Tyr Gln Leu Pro Pro His Asp
65                  70                  75                  80  
Asn Glu Val Arg Tyr Cys Gln Ser Leu Ser Glu Glu Glu Lys Lys Glu
                85                  90                  95      
Leu Gln Val Phe Ser Ala Gln Arg Lys Lys Glu Ala Leu Gly Arg Gly
            100                 105                 110         
Thr Ile Lys Leu Leu Ser Arg Ala Val Met His Ala Val Cys Glu Gln
        115                 120                 125             
Cys Gly Leu Lys Ile Asn Gly Gly Glu Val Ala Val Phe Ala Ser Arg
    130                 135                 140                 
Ala Gly Pro Gly Val Cys Trp His Pro Ser Cys Phe Val Cys Phe Thr
145                 150                 155                 160 
Cys Asn Glu Leu Leu Val Asp Leu Ile Tyr Phe Tyr Gln Asp Gly Lys
                165                 170                 175     
Ile His Cys Gly Arg His His Ala Glu Leu Leu Lys Pro Arg Cys Ser
            180                 185                 190         
Ala Cys Asp Glu Ile Ile Phe Ala Asp Glu Cys Thr Glu Ala Glu Gly
        195                 200                 205             
Arg His Trp His Met Lys His Phe Cys Cys Leu Glu Cys Glu Thr Val
    210                 215                 220                 
Leu Gly Gly Gln Arg Tyr Ile Met Lys Asp Gly Arg Pro Phe Cys Cys
225                 230                 235                 240 
Gly Cys Phe Glu Ser Leu Tyr Ala Glu Tyr Cys Glu Thr Cys Gly Glu
                245                 250                 255     
His Ile Gly Val Asp His Ala Gln Met Thr Tyr Asp Gly Gln His Trp
            260                 265                 270         
His Ala Thr Glu Ala Cys Phe Ser Cys Ala Gln Cys Lys Ala Ser Leu
        275                 280                 285             
Leu Gly Cys Pro Phe Leu Pro Lys Gln Gly Gln Ile Tyr Cys Ser Lys
    290                 295                 300                 
Thr Cys Ser Leu Gly Glu Asp Val His Ala Ser Asp Ser Ser Asp Ser
305                 310                 315                 320 
Ala Phe Gln Ser Ala Arg Ser Arg Asp Ser Arg Arg Ser Val Arg Met
                325                 330                 335     
Gly Lys Ser Ser Arg Ser Ala Asp Gln Cys Arg Gln Ser Leu Leu Leu
            340                 345                 350         
Ser Pro Ala Leu Asn Tyr Lys Phe Pro Gly Leu Ser Gly Asn Ala Asp
        355                 360                 365             
Asp Thr Leu Ser Arg Lys Leu Asp Asp Leu Ser Leu Ser Arg Gln Gly
    370                 375                 380                 
Thr Ser Phe Ala Ser Glu Glu Phe Trp Lys Gly Arg Val Glu Gln Glu
385                 390                 395                 400 
Thr Pro Glu Asp Pro Glu Glu Trp Ala Asp His Glu Asp Tyr Met Thr
                405                 410                 415     
Gln Leu Leu Leu Lys Phe Gly Asp Lys Ser Leu Phe Gln Pro Gln Pro
            420                 425                 430         
Asn Glu Met Asp Ile Arg Ala Ser Glu His Trp Ile Ser Asp Asn Met
        435                 440                 445             
Val Lys Ser Lys Thr Glu Leu Lys Gln Asn Asn Gln Ser Leu Ala Ser
    450                 455                 460                 
Lys Lys Tyr Gln Ser Asp Met Tyr Trp Ala Gln Ser Gln Asp Gly Leu
465                 470                 475                 480 
Gly Asp Ser Ala Tyr Gly Ser His Pro Gly Pro Ala Ser Ser Arg Arg
                485                 490                 495     
Leu Gln Glu Leu Glu Leu Asp His Gly Ala Ser Gly Tyr Asn His Asp
            500                 505                 510         
Glu Thr Gln Trp Tyr Glu Asp Ser Leu Glu Cys Leu Ser Asp Leu Lys
        515                 520                 525             
Pro Glu Gln Ser Val Arg Asp Ser Met Asp Ser Leu Ala Leu Ser Asn
    530                 535                 540                 
Ile Thr Gly Ala Ser Val Asp Gly Glu Asn Lys Pro Arg Pro Ser Leu
545                 550                 555                 560 
Tyr Ser Leu Gln Asn Phe Glu Glu Met Glu Thr Glu Asp Cys Glu Lys
                565                 570                 575     
Met Ser Asn Met Gly Thr Leu Asn Ser Ser Met Leu His Arg Ser Ala
            580                 585                 590         
Glu Ser Leu Lys Ser Leu Ser Ser Glu Leu Cys Pro Glu Lys Ile Leu
        595                 600                 605             
Pro Glu Glu Lys Pro Val His Leu Pro Val Leu Arg Arg Ser Lys Ser
    610                 615                 620                 
Gln Ser Arg Pro Gln Gln Val Lys Phe Ser Asp Asp Val Ile Asp Asn
625                 630                 635                 640 
Gly Asn Tyr Asp Ile Glu Ile Arg Gln Pro Pro Met Ser Glu Arg Thr
                645                 650                 655     
Arg Arg Arg Val Tyr Asn Phe Glu Glu Arg Gly Ser Arg Ser His His
            660                 665                 670         
His Arg Arg Arg Arg Ser Arg Lys Ser Arg Ser Asp Asn Ala Leu Asn
        675                 680                 685             
Leu Val Thr Glu Arg Lys Tyr Ser Pro Lys Asp Arg Leu Arg Leu Tyr
    690                 695                 700                 
Thr Pro Asp Asn Tyr Glu Lys Phe Ile Gln Asn Lys Ser Ala Arg Glu
705                 710                 715                 720 
Ile Gln Ala Tyr Ile Gln Asn Ala Asp Leu Tyr Gly Gln Tyr Ala His
                725                 730                 735     
Ala Thr Pro Asp Tyr Gly Leu Gln Asn Pro Gly Met Asn Arg Phe Leu
            740                 745                 750         
Gly Leu Tyr Gly Glu Asp Asp Asp Ser Trp Cys Ser Ser Ser Ser Ser
        755                 760                 765             
Ser Ser Asp Ser Glu Glu Glu Gly Tyr Phe Leu Gly Gln Pro Ile Pro
    770                 775                 780                 
Gln Pro Arg Pro Gln Arg Phe Ala Tyr Tyr Thr Asp Asp Leu Ser Ser
785                 790                 795                 800 
Pro Pro Ser Ala Leu Pro Thr Pro Gln Phe Gly Gln Arg Thr Thr Lys
                805                 810                 815     
Ser Lys Lys Lys Lys Gly His Lys Gly Lys Asn Cys Ile Ile Ser
            820                 825                 830     


<210> 2504
<211> 963
<212> PRT
<213> Homo sapiens

<400> 2504
Met Asp Ser Leu Pro Arg Leu Thr Ser Val Leu Thr Leu Leu Phe Ser
 1               5                  10                  15      
Gly Leu Trp His Leu Gly Leu Thr Ala Thr Asn Tyr Asn Cys Asp Asp
            20                  25                  30          
Pro Leu Ala Ser Leu Leu Ser Pro Met Ala Phe Ser Ser Ser Ser Asp
        35                  40                  45              
Leu Thr Gly Thr His Ser Pro Ala Gln Leu Asn Trp Arg Val Gly Thr
    50                  55                  60                  
Gly Gly Trp Ser Pro Ala Asp Ser Asn Ala Gln Gln Trp Leu Gln Met
65                  70                  75                  80  
Asp Leu Gly Asn Arg Val Glu Ile Thr Ala Val Ala Thr Gln Gly Arg
                85                  90                  95      
Tyr Gly Ser Ser Asp Trp Val Thr Ser Tyr Ser Leu Met Phe Ser Asp
            100                 105                 110         
Thr Gly Arg Asn Trp Lys Gln Tyr Lys Gln Glu Asp Ser Ile Trp Thr
        115                 120                 125             
Phe Ala Gly Asn Met Asn Ala Asp Ser Val Val His His Lys Leu Leu
    130                 135                 140                 
His Ser Val Arg Ala Arg Phe Val Arg Phe Val Pro Leu Glu Trp Asn
145                 150                 155                 160 
Pro Ser Gly Lys Ile Gly Met Arg Val Glu Val Tyr Gly Cys Ser Tyr
                165                 170                 175     
Lys Ser Asp Val Ala Asp Phe Asp Gly Arg Ser Ser Leu Leu Tyr Arg
            180                 185                 190         
Phe Asn Gln Lys Leu Met Ser Thr Leu Lys Asp Val Ile Ser Leu Lys
        195                 200                 205             
Phe Lys Ser Met Gln Gly Asp Gly Val Leu Phe His Gly Glu Gly Gln
    210                 215                 220                 
Arg Gly Asp His Ile Thr Leu Glu Leu Gln Lys Gly Arg Leu Ala Leu
225                 230                 235                 240 
His Leu Asn Leu Gly Asp Ser Lys Ala Arg Leu Ser Ser Ser Leu Pro
                245                 250                 255     
Ser Ala Thr Leu Gly Ser Leu Leu Asp Asp Gln His Trp His Ser Val
            260                 265                 270         
Leu Ile Glu Arg Val Gly Lys Gln Val Asn Phe Thr Val Asp Lys His
        275                 280                 285             
Thr Gln His Phe Arg Thr Lys Gly Glu Thr Asp Ala Leu Asp Ile Asp
    290                 295                 300                 
Tyr Glu Leu Ser Phe Gly Gly Ile Pro Val Pro Gly Lys Pro Gly Thr
305                 310                 315                 320 
Phe Leu Lys Lys Asn Phe His Gly Cys Ile Glu Asn Leu Tyr Tyr Asn
                325                 330                 335     
Gly Val Asn Ile Ile Asp Leu Ala Lys Arg Arg Lys His Gln Ile Tyr
            340                 345                 350         
Thr Val Gly Asn Val Thr Phe Ser Cys Ser Glu Pro Gln Ile Val Pro
        355                 360                 365             
Ile Thr Phe Val Asn Ser Ser Gly Ser Tyr Leu Leu Leu Pro Gly Thr
    370                 375                 380                 
Pro Gln Ile Asp Gly Leu Ser Val Ser Phe Gln Phe Arg Thr Trp Asn
385                 390                 395                 400 
Lys Asp Gly Leu Leu Leu Ser Thr Glu Leu Ser Glu Gly Ser Gly Thr
                405                 410                 415     
Leu Leu Leu Ser Leu Glu Gly Gly Ile Leu Arg Leu Val Ile Gln Lys
            420                 425                 430         
Met Thr Glu Arg Val Ala Glu Ile Leu Thr Gly Ser Asn Leu Asn Asp
        435                 440                 445             
Gly Pro Trp His Ser Val Ser Ile Asn Ala Arg Arg Asn Arg Ile Thr
    450                 455                 460                 
Leu Thr Leu Asp Asp Glu Ala Ala Pro Pro Ala Pro Asp Ser Thr Trp
465                 470                 475                 480 
Val Gln Ile Tyr Ser Gly Asn Ser Tyr Tyr Phe Gly Gly Cys Pro Asp
                485                 490                 495     
Asn Leu Thr Asp Ser Gln Cys Leu Asn Pro Ile Lys Ala Phe Gln Gly
            500                 505                 510         
Cys Met Arg Leu Ile Phe Ile Asp Asn Gln Pro Lys Asp Leu Ile Ser
        515                 520                 525             
Val Gln Gln Gly Ser Leu Gly Asn Phe Ser Asp Leu His Ile Asp Leu
    530                 535                 540                 
Cys Ser Ile Lys Asp Arg Cys Leu Pro Asn Tyr Cys Glu His Gly Gly
545                 550                 555                 560 
Ser Cys Ser Gln Ser Trp Thr Thr Phe Tyr Cys Asn Cys Ser Asp Thr
                565                 570                 575     
Ser Tyr Thr Gly Ala Thr Cys His Asn Ser Ile Tyr Glu Gln Ser Cys
            580                 585                 590         
Glu Val Tyr Arg His Gln Gly Asn Thr Ala Gly Phe Phe Tyr Ile Asp
        595                 600                 605             
Ser Asp Gly Ser Gly Pro Leu Gly Pro Leu Gln Val Tyr Cys Asn Ile
    610                 615                 620                 
Thr Glu Asp Lys Ile Trp Thr Ser Val Gln His Asn Asn Thr Glu Leu
625                 630                 635                 640 
Thr Arg Val Arg Gly Ala Asn Pro Glu Lys Pro Tyr Ala Met Ala Leu
                645                 650                 655     
Asp Tyr Gly Gly Ser Met Glu Gln Leu Glu Ala Val Ile Asp Gly Ser
            660                 665                 670         
Glu His Cys Glu Gln Glu Val Ala Tyr His Cys Arg Arg Ser Arg Leu
        675                 680                 685             
Leu Asn Thr Pro Asp Gly Thr Pro Phe Thr Trp Trp Ile Gly Arg Ser
    690                 695                 700                 
Asn Glu Arg His Pro Tyr Trp Gly Gly Ser Pro Pro Gly Val Gln Gln
705                 710                 715                 720 
Cys Glu Cys Gly Leu Asp Glu Ser Cys Leu Asp Ile Gln His Phe Cys
                725                 730                 735     
Asn Cys Asp Ala Asp Lys Asp Glu Trp Thr Asn Asp Thr Gly Phe Leu
            740                 745                 750         
Ser Phe Lys Asp His Leu Pro Val Thr Gln Ile Val Ile Thr Asp Thr
        755                 760                 765             
Asp Arg Ser Asn Ser Glu Ala Ala Trp Arg Ile Gly Pro Leu Arg Cys
    770                 775                 780                 
Tyr Gly Asp Arg Arg Phe Trp Asn Ala Val Ser Phe Tyr Thr Glu Ala
785                 790                 795                 800 
Ser Tyr Leu His Phe Pro Thr Phe His Ala Glu Phe Ser Ala Asp Ile
                805                 810                 815     
Ser Phe Phe Phe Lys Thr Thr Ala Leu Ser Gly Val Phe Leu Glu Asn
            820                 825                 830         
Leu Gly Ile Lys Asp Phe Ile Arg Leu Glu Ile Ser Ser Pro Ser Glu
        835                 840                 845             
Ile Thr Phe Ala Ile Asp Val Gly Asn Gly Pro Val Glu Leu Val Val
    850                 855                 860                 
Gln Ser Pro Ser Leu Leu Asn Asp Asn Gln Trp His Tyr Val Arg Ala
865                 870                 875                 880 
Glu Arg Asn Leu Lys Glu Thr Ser Leu Gln Val Asp Asn Leu Pro Arg
                885                 890                 895     
Ser Thr Arg Glu Thr Ser Glu Glu Gly His Phe Arg Leu Gln Leu Asn
            900                 905                 910         
Ser Gln Leu Phe Val Gly Gly Thr Ser Ser Arg Gln Lys Gly Phe Leu
        915                 920                 925             
Gly Cys Ile Arg Ser Leu His Leu Asn Gly Gln Lys Met Asp Leu Glu
    930                 935                 940                 
Glu Arg Ala Lys Val Thr Ser Gly Val Arg Pro Gly Cys Ser Ile Lys
945                 950                 955                 960 
Lys Leu Lys
            


<210> 2505
<211> 730
<212> PRT
<213> Homo sapiens

<400> 2505
Met Leu Lys Thr Ile Asn Leu Gln Asn Glu Gly Phe Thr Cys Thr Ile
 1               5                  10                  15      
Arg Tyr Arg Gln Ile Gly Pro Leu Ile Asp Arg Gln Ile Phe Arg Phe
            20                  25                  30          
Thr Glu Glu Gly Met Val Asn Ala Arg Phe Asp Tyr Asn Tyr Asp Asn
        35                  40                  45              
Ser Phe Arg Val Thr Ser Met Gln Ala Val Ile Asn Glu Thr Pro Leu
    50                  55                  60                  
Pro Ile Asp Leu Tyr Arg Tyr Asp Asp Val Ser Gly Lys Thr Glu Gln
65                  70                  75                  80  
Phe Gly Lys Phe Gly Val Ile Tyr Tyr Asp Ile Asn Gln Ile Ile Thr
                85                  90                  95      
Thr Ala Val Met Thr His Thr Lys His Phe Asp Ala Tyr Gly Arg Met
            100                 105                 110         
Lys Glu Val Gln Tyr Glu Ile Phe Arg Ser Leu Met Tyr Trp Met Thr
        115                 120                 125             
Val Gln Tyr Asp Asn Met Gly Arg Val Val Lys Lys Glu Leu Lys Val
    130                 135                 140                 
Gly Pro Tyr Ala Asn Thr Thr Arg Tyr Ser Tyr Glu Tyr Asp Ala Asp
145                 150                 155                 160 
Gly Gln Leu Gln Thr Val Ser Ile Asn Asp Lys Pro Leu Trp Arg Tyr
                165                 170                 175     
Ser Tyr Asp Leu Asn Gly Asn Leu His Leu Leu Ser Pro Gly Asn Ser
            180                 185                 190         
Ala Arg Leu Thr Pro Leu Arg Tyr Asp Ile Arg Asp Arg Ile Thr Arg
        195                 200                 205             
Leu Gly Asp Val Gln Tyr Lys Met Asp Glu Asp Gly Phe Leu Arg Gln
    210                 215                 220                 
Arg Gly Gly Asp Ile Phe Glu Tyr Asn Ser Ala Gly Leu Leu Ile Lys
225                 230                 235                 240 
Ala Tyr Asn Arg Ala Gly Ser Trp Ser Val Arg Tyr Arg Tyr Asp Gly
                245                 250                 255     
Leu Gly Arg Arg Val Ser Ser Lys Ser Ser His Ser His His Leu Gln
            260                 265                 270         
Phe Phe Tyr Ala Asp Leu Thr Asn Pro Thr Lys Val Thr His Leu Tyr
        275                 280                 285             
Asn His Ser Ser Ser Glu Ile Thr Ser Leu Tyr Tyr Asp Leu Gln Gly
    290                 295                 300                 
His Leu Phe Ala Met Glu Leu Ser Ser Gly Asp Glu Phe Tyr Ile Ala
305                 310                 315                 320 
Cys Asp Asn Ile Gly Thr Pro Leu Ala Val Phe Ser Gly Thr Gly Leu
                325                 330                 335     
Met Ile Lys Gln Ile Leu Tyr Thr Ala Tyr Gly Glu Ile Tyr Met Asp
            340                 345                 350         
Thr Asn Pro Asn Phe Gln Ile Ile Ile Gly Tyr His Gly Gly Leu Tyr
        355                 360                 365             
Asp Pro Leu Thr Lys Leu Val His Met Gly Arg Arg Asp Tyr Asp Val
    370                 375                 380                 
Leu Ala Gly Arg Trp Thr Ser Pro Asp His Glu Leu Trp Lys His Leu
385                 390                 395                 400 
Ser Ser Ser Asn Val Met Pro Phe Asn Leu Tyr Met Phe Lys Asn Asn
                405                 410                 415     
Asn Pro Ile Ser Asn Ser Gln Asp Ile Lys Cys Phe Met Thr Asp Val
            420                 425                 430         
Asn Ser Trp Leu Leu Thr Phe Gly Phe Gln Leu His Asn Val Ile Pro
        435                 440                 445             
Gly Tyr Pro Lys Pro Asp Met Asp Ala Met Glu Pro Ser Tyr Glu Leu
    450                 455                 460                 
Ile His Thr Gln Met Lys Thr Gln Glu Trp Asp Asn Ser Lys Ser Ile
465                 470                 475                 480 
Leu Gly Val Gln Cys Glu Val Gln Lys Gln Leu Lys Ala Phe Val Thr
                485                 490                 495     
Leu Glu Arg Phe Asp Gln Leu Tyr Gly Ser Thr Ile Thr Ser Cys Leu
            500                 505                 510         
Gln Ala Pro Lys Thr Lys Lys Phe Ala Ser Ser Gly Ser Val Phe Gly
        515                 520                 525             
Lys Gly Val Lys Phe Ala Leu Lys Asp Gly Arg Val Thr Thr Asp Ile
    530                 535                 540                 
Ile Ser Val Ala Asn Glu Asp Gly Arg Arg Val Ala Ala Ile Leu Asn
545                 550                 555                 560 
His Ala His Tyr Leu Glu Asn Leu His Phe Thr Ile Asp Gly Val Asp
                565                 570                 575     
Thr His Tyr Phe Val Lys Pro Gly Pro Ser Glu Gly Asp Leu Ala Ile
            580                 585                 590         
Leu Gly Leu Ser Gly Gly Arg Arg Thr Leu Glu Asn Gly Val Asn Val
        595                 600                 605             
Thr Val Ser Gln Ile Asn Thr Val Leu Ser Gly Arg Thr Arg Arg Tyr
    610                 615                 620                 
Thr Asp Ile Gln Leu Gln Tyr Gly Ala Leu Cys Leu Asn Thr Arg Tyr
625                 630                 635                 640 
Gly Thr Thr Leu Asp Glu Glu Lys Ala Arg Val Leu Glu Leu Ala Arg
                645                 650                 655     
Gln Arg Ala Val Arg Gln Ala Trp Ala Arg Glu Gln Gln Arg Leu Arg
            660                 665                 670         
Glu Gly Glu Glu Gly Leu Arg Ala Trp Thr Glu Gly Glu Lys Gln Gln
        675                 680                 685             
Val Leu Ser Thr Gly Arg Val Gln Gly Tyr Asp Gly Phe Phe Val Ile
    690                 695                 700                 
Ser Val Glu Gln Tyr Pro Glu Leu Ser Asp Ser Ala Asn Asn Ile His
705                 710                 715                 720 
Phe Met Arg Gln Ser Glu Met Gly Arg Arg
                725                 730 


<210> 2506
<211> 522
<212> PRT
<213> Homo sapiens

<400> 2506
Met Asp Phe Leu Leu Leu Gly Leu Cys Leu Tyr Trp Leu Leu Arg Arg
 1               5                  10                  15      
Pro Ser Gly Val Val Leu Cys Leu Leu Gly Ala Cys Phe Gln Met Leu
            20                  25                  30          
Pro Ala Ala Pro Ser Gly Cys Pro Gln Leu Cys Arg Cys Glu Gly Arg
        35                  40                  45              
Leu Leu Tyr Cys Glu Ala Leu Asn Leu Thr Glu Ala Pro His Asn Leu
    50                  55                  60                  
Ser Gly Leu Leu Gly Leu Ser Leu Arg Tyr Asn Ser Leu Ser Glu Leu
65                  70                  75                  80  
Arg Ala Gly Gln Phe Thr Gly Leu Met Gln Leu Thr Trp Leu Tyr Leu
                85                  90                  95      
Asp His Asn His Ile Cys Ser Val Gln Gly Asp Ala Phe Gln Lys Leu
            100                 105                 110         
Arg Arg Val Lys Glu Leu Thr Leu Ser Ser Asn Gln Ile Thr Gln Leu
        115                 120                 125             
Pro Asn Thr Thr Phe Arg Pro Met Pro Asn Leu Arg Ser Val Asp Leu
    130                 135                 140                 
Ser Tyr Asn Lys Leu Gln Ala Leu Ala Pro Asp Leu Phe His Gly Leu
145                 150                 155                 160 
Arg Lys Leu Thr Thr Leu His Met Arg Ala Asn Ala Ile Gln Phe Val
                165                 170                 175     
Pro Val Arg Ile Phe Gln Asp Cys Arg Ser Leu Lys Phe Leu Asp Ile
            180                 185                 190         
Gly Tyr Asn Gln Leu Lys Ser Leu Ala Arg Asn Ser Phe Ala Gly Leu
        195                 200                 205             
Phe Lys Leu Thr Glu Leu His Leu Glu His Asn Asp Leu Val Lys Val
    210                 215                 220                 
Asn Phe Ala His Phe Pro Arg Leu Ile Ser Leu His Ser Leu Cys Leu
225                 230                 235                 240 
Arg Arg Asn Lys Val Ala Ile Val Val Ser Ser Leu Asp Trp Val Trp
                245                 250                 255     
Asn Leu Glu Lys Met Asp Leu Ser Gly Asn Glu Ile Glu Tyr Met Glu
            260                 265                 270         
Pro His Val Phe Glu Thr Val Pro His Leu Gln Ser Leu Gln Leu Asp
        275                 280                 285             
Ser Asn Arg Leu Thr Tyr Ile Glu Pro Arg Ile Leu Asn Ser Trp Lys
    290                 295                 300                 
Ser Leu Thr Ser Ile Thr Leu Ala Gly Asn Leu Trp Asp Cys Gly Arg
305                 310                 315                 320 
Asn Val Cys Ala Leu Ala Ser Trp Leu Asn Asn Phe Gln Gly Arg Tyr
                325                 330                 335     
Asp Gly Asn Leu Gln Cys Ala Ser Pro Glu Tyr Ala Gln Gly Glu Asp
            340                 345                 350         
Val Leu Asp Ala Val Tyr Ala Phe His Leu Cys Glu Asp Gly Ala Glu
        355                 360                 365             
Pro Thr Ser Gly His Leu Leu Ser Ala Val Thr Asn Arg Ser Asp Leu
    370                 375                 380                 
Gly Pro Pro Ala Ser Ser Ala Thr Thr Leu Ala Asp Gly Gly Glu Gly
385                 390                 395                 400 
Gln His Asp Gly Thr Phe Glu Pro Ala Thr Val Ala Leu Pro Gly Gly
                405                 410                 415     
Glu His Ala Glu Asn Ala Val Gln Ile His Lys Val Val Thr Gly Thr
            420                 425                 430         
Met Ala Leu Ile Phe Ser Phe Leu Ile Val Val Leu Val Leu Tyr Val
        435                 440                 445             
Ser Trp Lys Cys Phe Pro Ala Ser Leu Arg Gln Leu Arg Gln Cys Phe
    450                 455                 460                 
Val Thr Gln Arg Arg Lys Gln Lys Gln Lys Gln Thr Met His Gln Met
465                 470                 475                 480 
Ala Ala Met Ser Ala Gln Glu Tyr Tyr Val Asp Tyr Lys Pro Asn His
                485                 490                 495     
Ile Glu Gly Ala Leu Val Thr Ile Asn Glu Tyr Gly Ser Cys Thr Cys
            500                 505                 510         
His Gln Gln Pro Ala Arg Glu Cys Glu Val
        515                 520         


<210> 2507
<211> 693
<212> PRT
<213> Homo sapiens

<400> 2507
Met Arg Thr Val Val Leu Thr Met Lys Ala Ser Val Ile Glu Met Phe
 1               5                  10                  15      
Leu Val Leu Leu Val Thr Gly Val His Ser Asn Lys Glu Thr Ala Lys
            20                  25                  30          
Lys Ile Lys Arg Pro Lys Phe Thr Val Pro Gln Ile Asn Cys Asp Val
        35                  40                  45              
Lys Ala Gly Lys Ile Ile Asp Pro Glu Phe Ile Val Lys Cys Pro Ala
    50                  55                  60                  
Gly Cys Gln Asp Pro Lys Tyr His Val Tyr Gly Thr Asp Val Tyr Ala
65                  70                  75                  80  
Ser Tyr Ser Ser Val Cys Gly Ala Ala Val His Ser Gly Val Leu Asp
                85                  90                  95      
Asn Ser Gly Gly Lys Ile Leu Val Arg Lys Val Ala Gly Gln Ser Gly
            100                 105                 110         
Tyr Lys Gly Ser Tyr Ser Asn Gly Val Gln Ser Leu Ser Leu Pro Arg
        115                 120                 125             
Trp Arg Glu Ser Phe Ile Val Leu Glu Ser Lys Pro Lys Lys Gly Val
    130                 135                 140                 
Thr Tyr Pro Ser Ala Leu Thr Tyr Ser Ser Ser Lys Ser Pro Ala Ala
145                 150                 155                 160 
Gln Ala Gly Glu Thr Thr Lys Ala Tyr Gln Arg Pro Pro Ile Pro Gly
                165                 170                 175     
Thr Thr Ala Gln Pro Val Thr Leu Met Gln Leu Leu Ala Val Thr Val
            180                 185                 190         
Ala Val Ala Thr Pro Thr Thr Leu Pro Arg Pro Ser Pro Ser Ala Ala
        195                 200                 205             
Ser Thr Thr Ser Ile Pro Arg Pro Gln Ser Val Gly His Arg Ser Gln
    210                 215                 220                 
Glu Met Asp Leu Trp Ser Thr Ala Thr Tyr Thr Ser Ser Gln Asn Arg
225                 230                 235                 240 
Pro Arg Ala Asp Pro Gly Ile Gln Arg Gln Asp Pro Ser Gly Ala Ala
                245                 250                 255     
Phe Gln Lys Pro Val Gly Ala Asp Val Ser Leu Gly Glu Met Asp Ser
            260                 265                 270         
Trp Lys Pro Gly Ser Val Leu Leu Asp Glu Gly Leu Val Pro Lys Glu
        275                 280                 285             
Glu Leu Ser Thr Gln Ser Leu Glu Pro Val Ser Leu Gly Asp Pro Asn
    290                 295                 300                 
Cys Lys Ile Asp Leu Ser Phe Leu Ile Asp Gly Ser Thr Ser Ile Gly
305                 310                 315                 320 
Lys Arg Arg Phe Arg Ile Gln Lys Gln Leu Leu Ala Asp Val Ala Gln
                325                 330                 335     
Ala Leu Asp Ile Gly Pro Ala Gly Pro Leu Met Gly Val Val Gln Tyr
            340                 345                 350         
Gly Asp Asn Pro Ala Thr His Phe Asn Leu Lys Thr His Thr Asn Ser
        355                 360                 365             
Arg Asp Leu Lys Thr Ala Ile Glu Lys Ile Thr Gln Arg Gly Gly Leu
    370                 375                 380                 
Ser Asn Val Gly Arg Ala Ile Ser Phe Val Thr Lys Asn Phe Phe Ser
385                 390                 395                 400 
Lys Ala Asn Gly Asn Arg Ser Gly Ala Pro Asn Val Val Val Val Met
                405                 410                 415     
Val Asp Gly Trp Pro Thr Asp Lys Val Glu Glu Ala Ser Arg Leu Ala
            420                 425                 430         
Arg Glu Ser Gly Ile Asn Ile Phe Phe Ile Thr Ile Glu Gly Ala Ala
        435                 440                 445             
Glu Asn Glu Lys Gln Tyr Val Val Glu Pro Asn Phe Ala Asn Lys Ala
    450                 455                 460                 
Val Cys Arg Thr Asn Gly Phe Tyr Ser Leu His Val Gln Ser Trp Phe
465                 470                 475                 480 
Gly Leu His Lys Thr Leu Gln Pro Leu Val Lys Arg Val Cys Asp Thr
                485                 490                 495     
Asp Arg Leu Ala Cys Ser Lys Thr Cys Leu Asn Ser Ala Asp Ile Gly
            500                 505                 510         
Phe Val Ile Asp Gly Ser Ser Ser Val Gly Thr Gly Asn Phe Arg Thr
        515                 520                 525             
Val Leu Gln Phe Val Thr Asn Leu Thr Lys Glu Phe Glu Ile Ser Asp
    530                 535                 540                 
Thr Asp Thr Arg Ile Gly Ala Val Gln Tyr Thr Tyr Glu Gln Arg Leu
545                 550                 555                 560 
Glu Phe Gly Phe Asp Lys Tyr Ser Ser Lys Pro Asp Ile Leu Asn Ala
                565                 570                 575     
Ile Lys Arg Val Gly Tyr Trp Ser Gly Gly Thr Ser Thr Gly Ala Ala
            580                 585                 590         
Ile Asn Phe Ala Leu Glu Gln Leu Phe Lys Lys Ser Lys Pro Asn Lys
        595                 600                 605             
Arg Lys Leu Met Ile Leu Ile Thr Asp Gly Arg Ser Tyr Asp Asp Val
    610                 615                 620                 
Arg Ile Pro Ala Met Ala Ala His Leu Lys Gly Val Ile Thr Tyr Ala
625                 630                 635                 640 
Ile Gly Val Ala Trp Ala Ala Gln Glu Glu Leu Glu Val Ile Ala Thr
                645                 650                 655     
His Pro Ala Arg Asp His Ser Phe Phe Val Asp Glu Phe Asp Asn Leu
            660                 665                 670         
His Gln Tyr Val Pro Arg Ile Ile Gln Asn Ile Cys Thr Glu Phe Asn
        675                 680                 685             
Ser Gln Pro Arg Asn
    690             


<210> 2508
<211> 419
<212> PRT
<213> Homo sapiens

<400> 2508
Met Ala Val Ser Asn Ile Arg Tyr Gly Ala Ala Val Thr Lys Glu Val
 1               5                  10                  15      
Gly Met Asp Leu Lys Asn Met Gly Ala Lys Asn Val Cys Leu Met Thr
            20                  25                  30          
Asp Lys Asn Leu Ser Lys Leu Pro Pro Val Gln Val Ala Met Asp Ser
        35                  40                  45              
Leu Val Lys Asn Gly Ile Pro Phe Thr Val Tyr Asp Asn Val Arg Val
    50                  55                  60                  
Glu Pro Thr Asp Ser Ser Phe Met Glu Ala Ile Glu Phe Ala Gln Lys
65                  70                  75                  80  
Gly Ala Phe Asp Ala Tyr Val Ala Val Gly Gly Gly Ser Thr Met Asp
                85                  90                  95      
Thr Cys Lys Ala Ala Asn Leu Tyr Ala Ser Ser Pro His Ser Asp Phe
            100                 105                 110         
Leu Asp Tyr Val Ser Ala Pro Ile Gly Lys Gly Lys Pro Val Ser Val
        115                 120                 125             
Pro Leu Lys Pro Leu Ile Ala Val Pro Thr Thr Ser Gly Thr Gly Ser
    130                 135                 140                 
Glu Thr Thr Gly Val Ala Ile Phe Asp Tyr Glu His Leu Lys Val Lys
145                 150                 155                 160 
Ile Gly Ile Thr Ser Arg Ala Ile Lys Pro Thr Leu Gly Leu Ile Asp
                165                 170                 175     
Pro Leu His Thr Leu His Met Pro Ala Arg Val Val Ala Asn Ser Gly
            180                 185                 190         
Phe Asp Val Leu Cys His Ala Leu Glu Ser Tyr Thr Thr Leu Pro Tyr
        195                 200                 205             
His Leu Arg Ser Pro Cys Pro Ser Asn Pro Ile Thr Arg Pro Ala Tyr
    210                 215                 220                 
Gln Gly Ser Asn Pro Ile Ser Asp Ile Trp Ala Ile His Ala Leu Arg
225                 230                 235                 240 
Ile Val Ala Lys Tyr Leu Lys Arg Ala Val Arg Asn Pro Asp Asp Leu
                245                 250                 255     
Glu Ala Arg Ser His Met His Leu Ala Ser Ala Phe Ala Gly Ile Gly
            260                 265                 270         
Phe Gly Asn Ala Gly Val His Leu Cys His Gly Met Ser Tyr Pro Ile
        275                 280                 285             
Ser Gly Leu Val Lys Met Tyr Lys Ala Lys Asp Tyr Asn Val Asp His
    290                 295                 300                 
Pro Leu Val Pro His Gly Leu Ser Val Val Leu Thr Ser Pro Ala Val
305                 310                 315                 320 
Phe Thr Phe Thr Ala Gln Met Phe Pro Glu Arg His Leu Glu Met Ala
                325                 330                 335     
Glu Ile Leu Gly Ala Asp Thr Arg Thr Ala Arg Ile Gln Asp Ala Gly
            340                 345                 350         
Leu Val Leu Ala Asp Thr Leu Arg Lys Phe Leu Phe Asp Leu Asp Val
        355                 360                 365             
Asp Asp Gly Leu Ala Ala Val Gly Tyr Ser Lys Ala Asp Ile Pro Ala
    370                 375                 380                 
Leu Val Lys Gly Thr Leu Pro Gln Glu Arg Val Thr Lys Leu Ala Pro
385                 390                 395                 400 
Arg Pro Gln Ser Glu Glu Asp Leu Ala Ala Leu Phe Glu Ala Ser Met
                405                 410                 415     
Lys Leu Tyr
            


<210> 2509
<211> 395
<212> PRT
<213> Homo sapiens

<400> 2509
Met Asp Leu Cys Gln Lys Asn Glu Thr Asp Leu Glu Asn Ala Glu Asn
 1               5                  10                  15      
Asn Glu Ile Gln Phe Thr Glu Glu Thr Glu Pro Thr Tyr Thr Cys Pro
            20                  25                  30          
Asp Gly Lys Ser Glu Lys Asn His Val Tyr Cys Leu Leu Asp Val Ser
        35                  40                  45              
Asp Ile Thr Leu Glu Gln Asp Glu Lys Ala Lys Glu Phe Ile Ile Gly
    50                  55                  60                  
Thr Gly Trp Glu Glu Ala Val Gln Gly Trp Gly Arg Thr Ser Pro Ala
65                  70                  75                  80  
Ala Cys Ile Trp Pro Arg Lys Ile Pro Lys Lys Ala Arg Val Gly Glu
                85                  90                  95      
Gly Ala Cys Ser Asp Cys Leu Val Cys Val Asn Leu Ser His Trp Ser
            100                 105                 110         
Leu Gln Thr Lys Pro Pro Thr Glu Gly Gly Pro Glu Lys Asp Gln Ser
        115                 120                 125             
Ser Pro Ser Gln Thr Gln Ala Ala Pro Gln Gly Pro Ser Thr Ala Ser
    130                 135                 140                 
Arg Ala Ile Ser Asp Ile Cys Phe Pro Thr Tyr Phe Arg Ala Glu Lys
145                 150                 155                 160 
Lys Ser Leu Gln Ile Lys Glu Phe Ile Trp Cys Asn Lys Asp Trp Ala
                165                 170                 175     
Ile Pro Gly Thr Asn Arg Gly Lys Ala Ser Gly Asn Pro Ser Gly Gly
            180                 185                 190         
Ala His Arg Gly Leu Ser Ile Pro Gly Pro Leu Thr Ser Arg Ala Leu
        195                 200                 205             
Leu Val Leu Pro Pro Leu Lys Ala Leu Leu Ser Asn Ala Leu Asp Val
    210                 215                 220                 
Leu Gly Lys Lys Ser Lys Asn Ser Phe Leu Gln Ser Glu Glu Lys Val
225                 230                 235                 240 
Leu Asp Val Glu Lys Asp Gly Cys Val Ala Tyr Ala Tyr Gly Leu Lys
                245                 250                 255     
Thr Ala Asp Gly Lys Gly Glu Lys Arg Ala Ser Glu Leu Ala Lys His
            260                 265                 270         
Pro Met Val Asn Asp Thr Pro Ser Ser Pro Ser Pro Ala Ala Gln Ile
        275                 280                 285             
Ser Leu Leu Thr Asp Pro Glu Gln Arg Cys Leu His Trp Ser Leu Leu
    290                 295                 300                 
Ser Glu Lys Asn Leu Ala Cys Pro Pro Asp Pro Ser Asn Val Arg Tyr
305                 310                 315                 320 
Leu Ala Ala Leu Gln Leu Leu Gln Lys Arg Gly Val Gln Ser Tyr Lys
                325                 330                 335     
Ser Lys Phe Lys Ala Lys Glu Pro Arg Ser Pro Val Ile Thr Arg Lys
            340                 345                 350         
His Val Leu Pro Lys Ala Lys Gln Glu Asn Arg Pro Gln Met Leu Glu
        355                 360                 365             
Thr Lys Val Phe Pro Arg Pro Val Leu Pro Ser Leu Thr Val Ser Arg
    370                 375                 380                 
Val Ile Ile Pro Val Ser Thr His Arg Ile Leu
385                 390                 395 


<210> 2510
<211> 766
<212> PRT
<213> Homo sapiens

<400> 2510
Met Glu Glu Ile Lys Pro Ala Ser Ala Ser Cys Val Ser Lys Glu Lys
 1               5                  10                  15      
Pro Ser Lys Val Ser Asp Leu Ile Ser Arg Phe Glu Gly Gly Ser Ser
            20                  25                  30          
Leu Ser Asn Tyr Ser Asp Leu Lys Lys Glu Ser Ala Val Asn Leu Asn
        35                  40                  45              
Ala Pro Arg Thr Pro Gly Arg His Gly Leu Thr Thr Thr Pro Gln Gln
    50                  55                  60                  
Lys Leu Leu Ser Gln His Leu Pro Gln Arg Gln Gly Asn Asp Ala Asp
65                  70                  75                  80  
Lys Thr Gln Gly Ala Gln Thr Cys Val Ala Asn Gly Val Met Ala Ala
                85                  90                  95      
Gln Asn Gln Met Glu Cys Glu Glu Glu Lys Ala Ala Thr Leu Ser Ser
            100                 105                 110         
Asp Thr Ser Ile Gln Ala Ser Glu Pro Leu Leu Asp Thr His Ile Val
        115                 120                 125             
Asn Gly Glu Arg Asp Glu Thr Ala Thr Ala Pro Ala Ser Pro Thr Thr
    130                 135                 140                 
Asp Ser Cys Asp Gly Asn Ala Ser Asp Ser Ser Tyr Arg Thr Pro Gly
145                 150                 155                 160 
Ile Gly Pro Val Leu Pro Leu Glu Glu Arg Gly Ala Glu Thr Glu Thr
                165                 170                 175     
Lys Val Gln Glu Arg Glu Asn Gly Glu Ser Pro Leu Glu Leu Glu Gln
            180                 185                 190         
Leu Asp Gln His His Glu Met Lys Glu Thr Asn Glu Gln Lys Leu His
        195                 200                 205             
Lys Ile Ala Asn Glu Leu Leu Leu Thr Glu Arg Ala Tyr Val Asn Arg
    210                 215                 220                 
Leu Asp Leu Leu Asp Gln Val Phe Tyr Cys Lys Leu Leu Glu Glu Ala
225                 230                 235                 240 
Asn Arg Gly Ser Phe Pro Ala Glu Met Val Asn Lys Ile Phe Ser Asn
                245                 250                 255     
Ile Ser Ser Ile Asn Ala Phe His Ser Lys Phe Leu Leu Pro Glu Leu
            260                 265                 270         
Glu Lys Arg Met Gln Glu Trp Glu Thr Thr Pro Arg Ile Gly Asp Ile
        275                 280                 285             
Leu Gln Lys Leu Ala Pro Phe Leu Lys Met Tyr Gly Glu Tyr Val Lys
    290                 295                 300                 
Gly Phe Asp Asn Ala Met Glu Leu Val Lys Asn Met Thr Glu Arg Ile
305                 310                 315                 320 
Pro Gln Phe Lys Ser Val Val Glu Glu Ile Gln Lys Gln Lys Ile Cys
                325                 330                 335     
Gly Ser Leu Thr Leu Gln His His Met Leu Glu Pro Val Gln Arg Ile
            340                 345                 350         
Pro Arg Tyr Glu Met Leu Leu Lys Asp Tyr Leu Arg Lys Leu Pro Pro
        355                 360                 365             
Asp Ser Leu Asp Trp Asn Asp Ala Lys Lys Ser Leu Glu Ile Ile Ser
    370                 375                 380                 
Thr Ala Ala Ser His Ser Asn Ser Ala Ile Arg Lys Met Glu Asn Leu
385                 390                 395                 400 
Lys Lys Leu Leu Glu Ile Tyr Glu Met Leu Gly Glu Glu Glu Asp Ile
                405                 410                 415     
Val Asn Pro Ser Asn Glu Leu Ile Lys Glu Gly Gln Ile Leu Lys Leu
            420                 425                 430         
Ala Ala Arg Asn Thr Ser Ala Gln Glu Arg Tyr Leu Phe Leu Phe Asn
        435                 440                 445             
Asn Met Leu Leu Tyr Cys Val Pro Lys Phe Ser Leu Val Gly Ser Lys
    450                 455                 460                 
Phe Thr Val Arg Thr Arg Val Gly Ile Asp Gly Met Lys Ile Val Glu
465                 470                 475                 480 
Thr Gln Asn Glu Glu Tyr Pro His Thr Phe Gln Val Ser Gly Lys Glu
                485                 490                 495     
Arg Thr Leu Glu Leu Gln Ala Ser Ser Ala Gln Asp Lys Glu Glu Trp
            500                 505                 510         
Ile Lys Ala Leu Gln Glu Thr Ile Asp Ala Phe His Gln Arg His Glu
        515                 520                 525             
Thr Phe Arg Asn Ala Ile Ala Lys Asp Asn Asp Ile His Ser Glu Val
    530                 535                 540                 
Ser Thr Ala Glu Leu Gly Lys Arg Ala Pro Arg Trp Ile Arg Asp Asn
545                 550                 555                 560 
Glu Val Thr Met Cys Met Lys Cys Lys Glu Pro Phe Asn Ala Leu Thr
                565                 570                 575     
Arg Arg Arg His His Cys Arg Ala Cys Gly Tyr Val Val Cys Trp Lys
            580                 585                 590         
Cys Ser Asp Tyr Lys Ala Gln Leu Glu Tyr Asp Gly Gly Lys Leu Ser
        595                 600                 605             
Lys Val Cys Lys Asp Cys Tyr Gln Ile Ile Ser Gly Phe Thr Asp Ser
    610                 615                 620                 
Glu Glu Lys Lys Arg Lys Gly Ile Leu Glu Ile Glu Ser Ala Glu Val
625                 630                 635                 640 
Ser Gly Asn Ser Val Val Cys Ser Phe Leu Gln Tyr Met Glu Lys Ser
                645                 650                 655     
Lys Pro Trp Gln Lys Ala Trp Cys Val Ile Pro Lys Gln Asp Pro Leu
            660                 665                 670         
Val Leu Tyr Met Tyr Gly Ala Pro Gln Asp Val Arg Ala Gln Ala Thr
        675                 680                 685             
Ile Pro Leu Leu Gly Tyr Val Val Asp Glu Met Pro Arg Ser Ala Asp
    690                 695                 700                 
Leu Pro His Ser Phe Lys Leu Thr Gln Ser Lys Ser Val His Ser Phe
705                 710                 715                 720 
Ala Ala Asp Ser Glu Glu Leu Lys Gln Lys Trp Leu Lys Val Ile Leu
                725                 730                 735     
Leu Ala Val Thr Gly Glu Thr Pro Gly Gly Pro Asn Glu His Pro Ala
            740                 745                 750         
Thr Leu Asp Asp His Pro Glu Pro Lys Lys Lys Ser Glu Cys
        755                 760                 765     


<210> 2511
<211> 1021
<212> PRT
<213> Homo sapiens

<400> 2511
Met Glu Lys Val Leu Gly Cys Glu Leu Leu Lys Gly Leu Asn Val Leu
 1               5                  10                  15      
Asp Leu Gly Leu Asn Met Glu Ile Leu Glu Glu Gln Met Leu His Glu
            20                  25                  30          
Ile Leu Cys Arg Glu Tyr Pro Glu Leu Glu Thr Arg Trp Gln Asp Leu
        35                  40                  45              
Lys Ile Arg Ala Leu Asp Thr Cys Lys Ala Val Glu Ala Ala Glu Glu
    50                  55                  60                  
Arg Leu Leu Thr Met Leu Leu Phe Gln Asn Pro Lys Arg Gln Lys Pro
65                  70                  75                  80  
Ala Lys Phe Leu Arg Asn Ile Val Arg Ala Gln Gly Lys Leu Cys Gln
                85                  90                  95      
Leu Arg Ala His Cys Glu Glu Leu Glu Gly Gln Lys Leu Gln Glu Met
            100                 105                 110         
Val Leu Trp Ala Pro Tyr Arg Pro Val Val Trp His Gly Met Ala Met
        115                 120                 125             
Val Lys Ala Leu Ser Gln Leu Gln Asn Leu Leu Pro Leu Phe Cys Met
    130                 135                 140                 
Ser Pro Glu Asn Trp Leu Ala Val Thr Lys Gln Ala Leu Asp Ser Met
145                 150                 155                 160 
Lys Pro Arg Glu Ile Asn His Gly Glu Asp Leu Ala Ser His Leu Leu
                165                 170                 175     
Gln Leu Arg Ala His Leu Thr Arg Gln Leu Leu Gly Ser Thr Val Thr
            180                 185                 190         
Ala Leu Gly Leu Thr Gln Val Pro Leu Val Gly Ala Leu Gly Ala Leu
        195                 200                 205             
Ala Leu Leu Gln Ala Thr Gly Lys Ala Ser Glu Leu Glu Arg Leu Ala
    210                 215                 220                 
Leu Trp Pro Gly Leu Ala Ala Ser Pro Ser Thr Val His Ser Lys Pro
225                 230                 235                 240 
Val Ser Asp Val Ala Arg Pro Ala Trp Leu Gly Pro Lys Ala Trp His
                245                 250                 255     
Glu Cys Glu Met Leu Glu Leu Leu Pro Pro Phe Val Gly Leu Cys Ala
            260                 265                 270         
Ser Leu Ala Gly His Ser Ser Ala Trp Gln Ala Tyr Leu Ser Leu Ser
        275                 280                 285             
Ser Thr Val Leu Gly Pro Ala Pro Gly Pro Gly Pro Glu Pro Leu Ser
    290                 295                 300                 
Leu Leu Gln Lys Leu Ile Leu Trp Arg Val Leu Arg Pro Glu Cys Leu
305                 310                 315                 320 
Ala Gly Ala Leu Ala Asp Phe Thr Thr Ser Leu Leu Gly Arg Pro Leu
                325                 330                 335     
Asp Glu Asn Thr Tyr Ala Pro Thr Met Pro Phe Lys His Ser Gln Ala
            340                 345                 350         
Thr Gln Pro Met Leu Ile Leu Leu Pro Pro Pro Gly His Pro Ser Ala
        355                 360                 365             
Thr Leu His Pro Leu Thr Val Ile Gln Lys Leu Ala Ala Lys Tyr Gln
    370                 375                 380                 
Gln Gly Gln Lys Gln Leu Gln Val Ile Ala Leu Gly Ser Glu Ala Trp
385                 390                 395                 400 
Asp Pro Val Ser Val Val Val Ser Thr Leu Ser Gln Ala Met Tyr Glu
                405                 410                 415     
Gly His Trp Leu Val Leu Asp Asn Cys His Leu Met Pro His Trp Pro
            420                 425                 430         
Lys Glu Leu Leu Gln Leu Leu Leu Glu Leu Leu Gly Arg Ala Lys Val
        435                 440                 445             
Val Ala Asp Leu Glu Ser Glu Gln Leu Leu Asp Gln Pro Glu Ser Arg
    450                 455                 460                 
Asn Val Ser Thr Val His Arg Asp Phe Arg Leu Trp Leu Ile Val Pro
465                 470                 475                 480 
Ala Glu Ser Ser Ala Ser Leu Pro Ala Val Leu Thr Gln His Ser Met
                485                 490                 495     
Pro Val Phe Trp Asn Gln Ser Leu Glu Leu Gly His Val Leu Ile Asp
            500                 505                 510         
Ser Val Glu Leu Ala Gln Gln Val Leu Tyr Met Gln Pro Pro Thr Gln
        515                 520                 525             
Ala Leu Pro Leu Leu Leu Leu His Gly Leu Leu Leu His Arg Gln Leu
    530                 535                 540                 
Tyr Gly Thr Arg Leu Gln Ala His Arg Gly Arg Trp Ser Gln Val Thr
545                 550                 555                 560 
Leu Thr Gln Val Leu Gln Thr Gln Asp Gln Leu Trp Ala Ser Leu Ser
                565                 570                 575     
Asn Pro Arg Ala Ala Met Gln Glu Leu Ala Ala Ser Val Phe Tyr Gly
            580                 585                 590         
Gly Pro Leu Gly Asp Thr Glu Asp Arg Glu Ala Leu Ile Ser Leu Thr
        595                 600                 605             
Gln Ala Cys Leu Ser Pro Ser Ser Gly Ser Trp Val Gln Pro His Thr
    610                 615                 620                 
Pro Gln Ser Leu Leu Ala Thr Leu Met Pro Leu Pro Glu Leu Arg Glu
625                 630                 635                 640 
Leu Asp Ala Met Ala Glu Cys Lys Ala Gln Met His Leu Leu Pro Ser
                645                 650                 655     
Pro Pro Glu Pro Arg Leu Cys Gly Leu Ser Glu Gly Pro Gln Ala Trp
            660                 665                 670         
Leu Leu Arg Arg Gln Ser Arg Ala Leu Leu Ser Ala Leu Gln Arg Ser
        675                 680                 685             
Ser Pro Val Trp Val Pro Glu Ser Arg Arg Gly Ala Gln Leu Ala Glu
    690                 695                 700                 
Arg Arg Leu Arg Gln Arg Leu Val Gln Val Asn Arg Arg Leu Glu Ser
705                 710                 715                 720 
Leu Gln Asp Leu Leu Thr His Val Ile Arg Gln Asp Glu Ser Asp Ala
                725                 730                 735     
Pro Trp Ser Val Leu Gly Pro Asn Ala Arg Arg Pro Leu Glu Gly Val
            740                 745                 750         
Leu Glu Thr Glu Ala Leu Glu Leu Ser Gln Leu Val Gly Thr Leu Gln
        755                 760                 765             
Arg Asp Leu Asp Cys Leu Leu Gln Gln Leu Lys Gly Ala Pro Pro Cys
    770                 775                 780                 
Pro Ser Arg Arg Cys Ala Ala Val Ala His Ala Leu Trp Thr Gly Arg
785                 790                 795                 800 
Leu Pro Leu Pro Trp Arg Pro His Ala Pro Ala Gly Pro Gln Pro Pro
                805                 810                 815     
Trp His Trp Leu Arg Gln Leu Ser Arg Arg Gly Gln Leu Leu Val Arg
            820                 825                 830         
Tyr Leu Gly Val Gly Ala Asp Ala Ser Ser Asp Val Pro Glu Arg Val
        835                 840                 845             
Phe His Leu Ser Ala Phe Arg His Pro Arg Arg Leu Leu Leu Ala Leu
    850                 855                 860                 
Arg Gly Glu Ala Ala Leu Asp Gln Asn Val Pro Ser Ser Asn Phe Pro
865                 870                 875                 880 
Gly Ser Arg Gly Ser Val Ser Ser Gln Leu Gln Tyr Lys Arg Leu Glu
                885                 890                 895     
Met Asn Ser Asn Pro Leu His Phe Arg Val Glu Asn Gly Pro Asn Pro
            900                 905                 910         
Thr Val Pro Glu Arg Gly Leu Leu Leu Ile Gly Leu Gln Val Leu His
        915                 920                 925             
Ala Glu Trp Asp Pro Ile Ala Gly Ala Leu Gln Asp Ser Pro Ser Ser
    930                 935                 940                 
Gln Pro Ser Pro Leu Pro Pro Val Ser Ile Ser Thr Gln Ala Pro Gly
945                 950                 955                 960 
Thr Ser Asp Leu Pro Ala Pro Ala Asp Leu Thr Val Tyr Ser Cys Pro
                965                 970                 975     
Val Tyr Met Gly Gly Pro Leu Gly Thr Ala Lys Leu Gln Ser Arg Asn
            980                 985                 990         
Ile Val Met His Leu Pro Leu Pro Thr Lys Leu Thr Pro Asn Thr Cys
        995                 1000                1005            
Val Gln Arg Arg Val His Val Cys Ser Pro Pro Leu Ser
    1010                1015                1020    


<210> 2512
<211> 418
<212> PRT
<213> Homo sapiens

<400> 2512
Met Asn Val Cys Lys Asp Ser Pro Arg Asn Lys Val Asn Gln Lys Ser
 1               5                  10                  15      
Lys Val Met Glu Lys Lys Leu Pro Gln His Trp Thr Ala Glu Thr Thr
            20                  25                  30          
Lys Asp Leu Gly Pro Phe Leu Val Leu Phe Ser Gly Asp Glu Leu Ser
        35                  40                  45              
Ser Ile Ala Thr Lys Phe Pro Glu Ile Leu Leu Gln Ala Ala Ser Lys
    50                  55                  60                  
Met Ala Arg Thr Leu Pro Thr Lys Glu Phe Leu Trp Ala Val Phe Gln
65                  70                  75                  80  
Ser Val Arg Asn Ser Ser Asp Lys Ile Pro Ser Tyr Asp Pro Met Pro
                85                  90                  95      
Gly Cys His Gly Val Val Ala Pro Ser Ser Asp Asp Ile Phe Lys Leu
            100                 105                 110         
Ala Glu Ala Asn Ala Cys Trp Ala Leu Glu Asp Leu Arg Cys Met Glu
        115                 120                 125             
Glu Asp Thr Phe Ile Arg Thr Val Glu Leu Leu Gly Ala Val Gln Gly
    130                 135                 140                 
Phe Ser Arg Pro Gln Leu Met Thr Leu Lys Glu Lys Ala Ile Gln Val
145                 150                 155                 160 
Trp Asp Met Pro Ser Tyr Trp Arg Glu His His Ile Val Ser Leu Gly
                165                 170                 175     
Arg Ile Ala Leu Ala Leu Asn Glu Ser Glu Leu Glu Gln Leu Asp Leu
            180                 185                 190         
Ser Ser Ile Asp Thr Val Ala Ser Leu Ser Trp Gln Thr Glu Trp Thr
        195                 200                 205             
Pro Gly Gln Ala Glu Ser Ile Leu Gln Gly Tyr Leu Asp Asp Ser Gly
    210                 215                 220                 
Tyr Ser Ile Gln Asp Leu Lys Ser Phe His Leu Val Gly Leu Gly Ala
225                 230                 235                 240 
Thr Leu Cys Ala Ile Asn Ile Thr Glu Ile Pro Leu Ile Lys Ile Ser
                245                 250                 255     
Glu Phe Arg Val Val Val Ala Arg Ile Gly Thr Leu Leu Cys Ser Thr
            260                 265                 270         
His Val Leu Ala Glu Phe Lys Arg Lys Ala Glu Val Val Phe Gly Asp
        275                 280                 285             
Pro Thr Glu Trp Thr Ser Ser Val Leu Gln Glu Leu Gly Thr Ile Ala
    290                 295                 300                 
Ala Gly Leu Thr Lys Ala Glu Leu Arg Met Leu Asp Lys Asp Leu Met
305                 310                 315                 320 
Pro Tyr Phe Gln Pro Ser Ala Ile Lys Cys Leu Pro Asp Glu Ile Phe
                325                 330                 335     
Lys Glu Leu Ser Ala Glu Gln Ile Ala Ser Leu Gly Pro Glu Asn Ala
            340                 345                 350         
Ala Ala Val Thr His Ala Gln Arg Arg Arg Leu Ser Pro Leu Gln Leu
        355                 360                 365             
Gln Ser Leu Gln Gln Ala Leu Asp Gly Ala Lys Thr His Ser Trp Gln
    370                 375                 380                 
Asp Ala Pro Ala Ser Ala Gly Pro Thr Arg Thr Ser Ser Ser Arg Ser
385                 390                 395                 400 
Pro Ala Gly Ala Leu Gln Ser Trp Gly Leu Gly Leu Val Val Pro Cys
                405                 410                 415     
Trp Phe
        


<210> 2513
<211> 343
<212> PRT
<213> Homo sapiens

<400> 2513
Met Pro Arg Gly Gln Lys Ser Lys Leu Arg Ala Arg Glu Lys Arg His
 1               5                  10                  15      
Gln Ala Arg Cys Glu Asn Gln Asp Leu Gly Ala Thr Gln Ala Thr Val
            20                  25                  30          
Ala Glu Gly Glu Ser Pro Ser Ser Ala Tyr Leu Leu Phe Gly Asp Arg
        35                  40                  45              
Pro Gln Asn Leu Pro Ala Ala Glu Thr Pro Ser Ile Pro Glu Ala Leu
    50                  55                  60                  
Gln Gly Ala Pro Ser Thr Thr Asn Ala Ile Ala Pro Val Ser Cys Ser
65                  70                  75                  80  
Ser Asn Glu Gly Ala Ser Ser Gln Asp Glu Lys Ser Leu Gly Ser Ser
                85                  90                  95      
Arg Glu Ala Glu Gly Trp Lys Glu Asp Pro Leu Asn Lys Lys Val Val
            100                 105                 110         
Ser Leu Val His Phe Leu Leu Gln Lys Tyr Glu Thr Lys Glu Pro Ile
        115                 120                 125             
Thr Lys Gly Asp Met Ile Lys Phe Val Ile Arg Lys Asp Lys Cys His
    130                 135                 140                 
Phe Asn Glu Ile Leu Lys Arg Ala Ser Glu His Met Glu Leu Ala Leu
145                 150                 155                 160 
Gly Val Asp Leu Lys Glu Val Asp Pro Ile Arg His Tyr Tyr Ala Phe
                165                 170                 175     
Phe Ser Lys Leu Asp Leu Thr Tyr Asp Glu Thr Thr Ser Asp Glu Glu
            180                 185                 190         
Lys Ile Pro Lys Thr Gly Leu Leu Met Ile Ala Leu Gly Val Ile Phe
        195                 200                 205             
Leu Asn Gly Asn Arg Ala Pro Glu Glu Ala Val Trp Glu Ile Met Asn
    210                 215                 220                 
Met Met Gly Val Tyr Ala Asp Arg Lys His Phe Leu Tyr Gly Asp Pro
225                 230                 235                 240 
Arg Lys Val Met Thr Lys Asp Leu Val Gln Leu Lys Tyr Leu Glu Tyr
                245                 250                 255     
Gln Gln Val Pro Asn Ser Asp Pro Pro Arg Tyr Glu Phe Leu Trp Gly
            260                 265                 270         
Pro Arg Ala His Ala Glu Thr Ser Lys Met Lys Val Leu Glu Phe Val
        275                 280                 285             
Ala Lys Ile His Asp Thr Val Pro Ser Ala Phe Pro Ser Cys Tyr Glu
    290                 295                 300                 
Glu Ala Leu Arg Asp Glu Glu Gln Arg Thr Gln Ala Arg Ala Ala Ala
305                 310                 315                 320 
Arg Ala His Thr Ala Ala Met Ala Asn Ala Arg Ser Arg Thr Thr Ser
                325                 330                 335     
Ser Ser Phe Ser His Ala Lys
            340             


<210> 2514
<211> 570
<212> PRT
<213> Homo sapiens

<400> 2514
Met Ala Tyr Glu Lys Ser Thr Asp Ile Ser Asp Val Ser Arg Ser Met
 1               5                  10                  15      
Phe Leu Tyr Pro Trp Leu Glu Tyr Pro Asp Lys Thr Lys Glu Leu Arg
            20                  25                  30          
Lys Ala Met Ala Pro Val His Leu Pro Leu Ser Cys Tyr Gln Met Pro
        35                  40                  45              
Lys Glu Glu Phe Pro Pro Ser Pro Glu Cys Trp Arg Gln His Pro Ser
    50                  55                  60                  
Lys Pro Asn Ser Val Pro Tyr Cys Tyr Phe Lys Lys Pro Glu Ile Tyr
65                  70                  75                  80  
Thr His Trp His Asp Leu Tyr Asp Gln Arg Glu Glu Arg Glu Ala Glu
                85                  90                  95      
Lys Met Leu Arg Lys Met Arg Asp Asp Cys Arg Tyr Ile Lys Glu Val
            100                 105                 110         
His Gln Thr His Ile Lys Met Phe His Leu Pro Met Ser Lys Leu Thr
        115                 120                 125             
Ile Lys Ser Glu Met Arg Ser Arg Pro Leu Glu Pro Thr Gln Asp Pro
    130                 135                 140                 
Leu Lys Trp Gln Arg Leu Arg Glu Leu Thr Lys Ser Leu Glu Ser Pro
145                 150                 155                 160 
Arg Glu Asp Glu Gln Phe Tyr Ala Ala Gln Ala Leu Gly Cys Leu Arg
                165                 170                 175     
Ile Ser Asp Lys Phe Val Met Glu Ala Leu Gln Gln Val Ala Gln Thr
            180                 185                 190         
Gly Pro Glu Lys Val Lys Tyr Glu Ala Tyr Arg Thr Leu Ala Ile Leu
        195                 200                 205             
Gly Cys Leu Asn Lys His Val Ile Arg Ala Leu Ile Lys Arg Leu Lys
    210                 215                 220                 
Glu Lys Asn Glu Gly Gln Arg Met Glu Thr Leu Thr Gly Leu Arg Met
225                 230                 235                 240 
Ala Leu Asn Ser Trp Ala Ala Val Ser Lys Asp Lys Arg Thr Gln Val
                245                 250                 255     
Gly Asp Glu Gly Lys Leu Val Pro Val Leu Gln Thr Leu Ile Lys Lys
            260                 265                 270         
Ser Ser Ser Glu Ala Ser Leu Glu Ala Ala Leu Cys Leu Gly Phe Leu
        275                 280                 285             
Arg Pro Cys Ser Asn Met Val Gln Glu Phe Leu Leu Gln Cys Leu Cys
    290                 295                 300                 
Gln Gly Leu Lys Thr Gln Arg Met Lys Ala Leu Arg Met Leu Val Lys
305                 310                 315                 320 
Val Met His Val His Ser Ala Pro Val Ile Lys Ala Ile Leu Asp Gln
                325                 330                 335     
Leu Cys Ser Ser Ser Val Leu Glu Asp Arg Phe Glu Ala Thr Gln Met
            340                 345                 350         
Leu Lys Thr Ile Gly Leu Glu Gln Ile Gln Ala Gln Gly Leu Glu Glu
        355                 360                 365             
Leu Thr Phe Asn Leu Leu Arg Arg Lys Thr His Asn Glu Pro Phe Leu
    370                 375                 380                 
Ala Val Arg Gln Ala Val Ala Gln Thr Val Glu Glu Leu Lys Leu Lys
385                 390                 395                 400 
Pro Thr Met Met Asn Leu Val Glu Ala Gln Leu Met Asn Pro Asp Ala
                405                 410                 415     
Thr Ala Arg Gln Glu Ala Val Ile Ser Leu Gly Val Leu Gly Ile Arg
            420                 425                 430         
Ser Pro Gln Val Phe His Leu Leu Leu Asp Leu Leu Asp Ala Glu Asn
        435                 440                 445             
His Gln Ala Val Lys Lys Ser Leu Gln Glu Thr Leu Ile Leu Cys Ala
    450                 455                 460                 
Ser Ile Asp Pro Trp Ile Gln Asn Lys Leu Lys Asn Lys Val Leu Phe
465                 470                 475                 480 
Val Tyr Glu Ala Pro Lys Thr Asn Val Lys Ala Glu Pro Thr Arg Phe
                485                 490                 495     
Gln Lys Glu Pro Glu Asn Pro Glu Glu Leu Thr Ile Gln Asp Phe Arg
            500                 505                 510         
Leu Ala Lys Leu Asn Pro Leu Phe Ile Ala Lys Ser Ile Thr Lys Val
        515                 520                 525             
Gly Gln Lys Lys Thr Pro Ala Phe Pro Pro Cys Cys Ser Lys Pro Arg
    530                 535                 540                 
Lys His Arg Pro Gln Val Ile Gly Pro Trp Gln Pro Arg Ile Lys Lys
545                 550                 555                 560 
Gln Leu Arg Val Leu Ala Glu Ile Ala Lys
                565                 570 


<210> 2515
<211> 443
<212> PRT
<213> Homo sapiens

<400> 2515
Met Lys Pro Asn Lys Arg Val Glu Val Ala Gln Leu Asn Asp Val Met
 1               5                  10                  15      
Asp Thr Met Leu Glu Arg Ala Gly Val Glu Asn Gln Glu Tyr Thr Gly
            20                  25                  30          
Pro Thr Lys Met His Lys Leu Leu His Ile Leu Lys Lys Glu Gln Thr
        35                  40                  45              
Ile Tyr Asn Met Ile Phe His Glu Leu Ile Arg Gln Val Ser Val Asp
    50                  55                  60                  
Cys Ala Asp Arg Gly Glu Leu Leu Ser Lys Val Arg Glu Arg Tyr Val
65                  70                  75                  80  
Gln Met Leu Asp Gln Ile Ala Arg Gln Met Ile Asp Phe Tyr Lys Asp
                85                  90                  95      
Leu Val Thr Gln Arg Val Met Asp Gln Arg Ile Leu Glu Glu Leu Tyr
            100                 105                 110         
Asn Phe Lys His Val Ile Glu Glu Leu Thr Arg Glu Leu Cys Leu Val
        115                 120                 125             
Arg Ala His Asp Val Lys Leu Thr Lys Glu Thr Glu Lys Ala His Lys
    130                 135                 140                 
Asp Leu Ala Gln Ala Leu Leu Asn Ala Glu Lys Asn Ala Lys Ile Val
145                 150                 155                 160 
Glu Glu Tyr His Asp Leu Tyr Thr Leu Gln Arg Glu Arg Met Glu Asn
                165                 170                 175     
Asp Met Lys Lys Leu Val Ala Glu Arg Asp Ile Trp Ser Ser Ala Thr
            180                 185                 190         
Tyr Glu Leu Ala Leu Lys Val Ile Glu Arg Asn Arg Val Ile Leu Ala
        195                 200                 205             
Arg Arg Leu Tyr Leu Asn Glu Lys Gly Trp Asn Lys Tyr Thr Lys His
    210                 215                 220                 
Phe Ile Ile Leu Leu Ser Asn Lys Asp Thr Glu Asp Leu Ala Leu Leu
225                 230                 235                 240 
Gln Lys Leu Thr Gln Lys Trp Arg Asn Leu Val Asn Lys Leu Lys Gln
                245                 250                 255     
Glu Val Glu Gln Met Glu Glu Ser Thr Ser Glu Thr Leu Lys Ile Val
            260                 265                 270         
Lys Asp Gly Leu Ile Lys Trp Gln Glu Phe Phe Asn Glu Lys Asp Ile
        275                 280                 285             
Leu Ser Pro Asn Lys Gly Asn Ile Phe Asn Ser Val Leu Leu Asp Phe
    290                 295                 300                 
Lys Gln Trp Gln Lys Ile Leu Asn Glu Lys Lys Glu Glu Phe Thr Gly
305                 310                 315                 320 
Asp Val Leu Leu Ser Lys Tyr Asp Thr Leu Lys Ile Ile Lys His Leu
                325                 330                 335     
Gln Glu Asn Trp Ala Asp Ile Gly Leu Gly Ile Phe Asn Arg His Lys
            340                 345                 350         
Ser Leu Glu Gly Glu Met Pro Ser Glu Arg Gln Tyr Met Glu Glu Ile
        355                 360                 365             
Ile Lys Asn Ile Gln Lys Leu Tyr Lys Glu Tyr Glu Ile Arg Ile Asn
    370                 375                 380                 
Gly Asp Asn Glu Thr Gly Ser His Arg Val Ala Gln Ala Gly Leu Lys
385                 390                 395                 400 
Leu Leu Gly Ser Ser Asp His Pro Thr Ser Ala Pro Gln Ser Ala Gly
                405                 410                 415     
Ile Arg Gly Ile Ile His Arg Thr Trp Pro Trp Val Asn Phe Tyr Ile
            420                 425                 430         
Val Cys Glu Val Thr Pro Lys Phe Phe Gln Val
        435                 440             


<210> 2516
<211> 504
<212> PRT
<213> Homo sapiens

<400> 2516
Met Ile Gln Gly Lys Glu Asp Asp Ile Tyr Leu Met Val Ile Trp Glu
 1               5                  10                  15      
Leu Pro Asp Val Val Pro Phe Leu Gln Asp Gly Lys His Ala Val His
            20                  25                  30          
Leu Arg Met Ser Thr Arg Asp Arg Asn Met Ala Ile Pro Phe Pro Asp
        35                  40                  45              
Val Glu Leu Ile Val Glu Arg Asn Phe Ser Gln Pro Thr Asp Asn Pro
    50                  55                  60                  
Thr Met Asp Leu Leu Arg Val Asn Cys Ile Asp Leu Leu Gln Val Glu
65                  70                  75                  80  
Gly Tyr Asn Leu Ile Ala Ala Gly Thr Leu Asn Gly Val Ile Ile Leu
                85                  90                  95      
Trp Asn Phe Val Thr Ser Thr Val Lys Lys Val Tyr Arg Pro Glu Asp
            100                 105                 110         
Cys Phe Thr Val Asn Pro Asp Leu His Ser Lys His Phe Lys Ile Asn
        115                 120                 125             
Asp Ile Leu Phe Leu Phe Arg Thr Pro Glu Cys Ala Arg Arg Ser Ser
    130                 135                 140                 
Gln Asp Ser Ile Cys Ser Ser Ser Gln Cys Glu Ser Ser Lys Gly Pro
145                 150                 155                 160 
Gln Ser Ser Lys Gly Ser Lys Gln Ser Ile His Asp Ser Glu Val Lys
                165                 170                 175     
Gly Glu Gln Thr Asp Val Met Val Gly Lys Gln Gln Pro Met Asp Lys
            180                 185                 190         
Lys His Pro Gly Ile Ala Asn Leu Pro Glu Ala Gln Pro Pro Ile Leu
        195                 200                 205             
Val Thr Ala His Glu Asp Gly His Leu Arg Leu Trp Thr Leu Glu Gly
    210                 215                 220                 
Arg Leu Leu Lys Asp Met Leu Pro Phe Thr Lys His Ser Ala Ile Ser
225                 230                 235                 240 
Leu Thr Ser Leu Tyr Thr Asp Ser Cys Thr Arg Ile Leu Leu Ala Gly
                245                 250                 255     
Asn Val Glu Gly His Val Ile Leu Cys Asn Ile Ser Ser Phe Leu Asp
            260                 265                 270         
Pro Pro His Asp Glu Lys Lys Phe Lys Gln Leu Leu Ser Trp Arg Ala
        275                 280                 285             
His Ser Leu Glu Ile Ile Gln Val Ile Tyr Val Glu Glu Lys Gln Val
    290                 295                 300                 
Val Leu Thr Ala Ser Ile Asp Gly Ser Val Arg Leu Trp His Ala Leu
305                 310                 315                 320 
Asn Gly His Tyr Cys Gly Tyr Phe Gly Gln Arg Arg Leu Phe Glu Leu
                325                 330                 335     
Ser Gln Thr Arg Asp Phe Ile Leu Pro Cys Asp Val Thr Glu Tyr Pro
            340                 345                 350         
Ile Glu Ile Lys Glu Glu Ser Lys Phe Thr Glu Lys Gln Lys Tyr Glu
        355                 360                 365             
Tyr Pro Leu Ile Phe Asp Arg Glu Lys Trp Arg Lys Met Ser Ser Val
    370                 375                 380                 
Ser Leu Leu Phe Lys Arg Thr Pro Pro Lys Ala Phe Glu Val Glu Gln
385                 390                 395                 400 
Asp Phe Lys Phe Phe Lys Ser Leu Ser Ser Pro Lys Ile Arg Arg Tyr
                405                 410                 415     
Pro Leu Glu Gly Phe Val Thr Glu Asn Arg Glu Ala Gly Ile Val Phe
            420                 425                 430         
Gly Ser Leu Pro Ile Tyr Ser Ile Ser Ser Pro Thr Ser Leu Arg Phe
        435                 440                 445             
Leu Pro Leu Ile Gly Val Glu Ala Gln Lys Asp Ser Ser Asp Gly Ile
    450                 455                 460                 
Thr Gly Lys Lys Lys Gly Gly His Val Gln Arg Glu Lys Ala Pro Arg
465                 470                 475                 480 
Arg Arg Ser Leu Lys Lys Asn Leu Val Pro Gln Ile Asn Leu Ala Ser
                485                 490                 495     
Ser Phe Phe Pro Ala Ile Pro Lys
            500                 


<210> 2517
<211> 380
<212> PRT
<213> Homo sapiens

<400> 2517
Met Ser Gly Ala Gly Val Ala Ala Gly Thr Arg Pro Pro Ser Ser Pro
 1               5                  10                  15      
Thr Pro Gly Ser Arg Arg Arg Arg Gln Arg Pro Ser Val Gly Val Gln
            20                  25                  30          
Ser Leu Arg Pro Gln Ser Pro Gln Leu Arg Gln Ser Asp Pro Gln Lys
        35                  40                  45              
Arg Asn Leu Asp Leu Glu Lys Ser Leu Gln Phe Leu Gln Gln Gln His
    50                  55                  60                  
Ser Glu Met Leu Ala Lys Leu His Glu Glu Ile Glu His Leu Lys Arg
65                  70                  75                  80  
Glu Asn Lys Asp Leu Arg Tyr Lys Leu Ile Met Asn Gln Thr Ser Gln
                85                  90                  95      
Lys Lys Asp Gly Pro Ser Gly Asn His Leu Ser Arg Ala Ser Ala Pro
            100                 105                 110         
Leu Gly Ala Arg Trp Val Cys Ile Asn Gly Val Trp Val Glu Pro Gly
        115                 120                 125             
Gly Pro Ser Pro Ala Arg Leu Lys Glu Gly Ser Ser Arg Thr His Arg
    130                 135                 140                 
Pro Gly Gly Lys His Gly Arg Leu Ala Gly Gly Ser Ala Asp Thr Val
145                 150                 155                 160 
Arg Ser Pro Ala Asp Ser Leu Ser Thr Ser Ser Phe Gln Ser Val Lys
                165                 170                 175     
Ser Ile Ser Asn Ser Gly Lys Ala Arg Pro Gln Pro Gly Ser Phe Asn
            180                 185                 190         
Lys Gln Asp Ser Lys Ala Asp Val Pro Gln Lys Ala Asp Leu Glu Glu
        195                 200                 205             
Glu Pro Leu Leu His Asn Ser Lys Leu Asp Lys Val Pro Gly Val Gln
    210                 215                 220                 
Gly Gln Ala Arg Lys Glu Lys Ala Glu Ala Ser Asn Ala Gly Ala Ala
225                 230                 235                 240 
Cys Met Gly Asn Ser Gln His Gln Gly Arg Gln Met Gly Ala Ala Ala
                245                 250                 255     
His Pro Pro Met Ile Leu Pro Leu Pro Leu Arg Lys Pro Thr Thr Leu
            260                 265                 270         
Arg Gln Cys Glu Val Leu Ile Arg Glu Leu Trp Asn Thr Asn Leu Leu
        275                 280                 285             
Gln Thr Gln Glu Leu Gln His Leu Lys Ser Leu Leu Glu Gly Ser Gln
    290                 295                 300                 
Arg Pro Gln Ala Val Pro Glu Glu Ala Ser Phe Pro Arg Asp Gln Glu
305                 310                 315                 320 
Ala Thr His Phe Pro Lys Val Ser Thr Lys Ser Leu Ser Lys Lys Cys
                325                 330                 335     
Leu Leu Leu Ser Pro Pro Val Ala Glu Arg Ala Ile Leu Pro Ala Leu
            340                 345                 350         
Lys Gln Thr Pro Lys Asn Asn Phe Ala Glu Arg Gln Lys Arg Leu Gln
        355                 360                 365             
Ala Met Gln Lys Arg Arg Leu His Arg Ser Val Leu
    370                 375                 380 


<210> 2518
<211> 427
<212> PRT
<213> Homo sapiens

<400> 2518
Met Ala Gln Pro Gly Thr Leu Asn Leu Asn Asn Glu Val Val Lys Met
 1               5                  10                  15      
Arg Lys Glu Val Lys Arg Ile Arg Val Leu Val Ile Arg Lys Leu Val
            20                  25                  30          
Arg Ser Val Gly Arg Leu Lys Ser Lys Lys Gly Thr Glu Asp Ala Leu
        35                  40                  45              
Leu Lys Asn Gln Arg Arg Ala Gln Arg Leu Leu Glu Glu Ile His Ala
    50                  55                  60                  
Met Lys Glu Leu Lys Pro Asp Ile Val Thr Lys Ser Ala Leu Gly Asp
65                  70                  75                  80  
Asp Ile Asn Phe Glu Lys Ile Phe Lys Lys Pro Asp Ser Thr Ala Thr
                85                  90                  95      
Glu Arg Ala Ile Ala Arg Leu Ala Val His Pro Leu Leu Lys Lys Lys
            100                 105                 110         
Ile Asp Val Leu Lys Ala Ala Val Gln Ala Phe Lys Glu Ala Arg Gln
        115                 120                 125             
Asn Val Ala Glu Val Glu Ser Ser Lys Asn Ala Ser Glu Asp Asn His
    130                 135                 140                 
Ser Glu Asn Thr Leu Tyr Ser Asn Asp Asn Gly Ser Asn Leu Gln Arg
145                 150                 155                 160 
Glu Ala Thr Val Ile Ser Glu Gln Lys Val Lys Glu Thr Lys Ile Leu
                165                 170                 175     
Ala Lys Lys Pro Ile His Asn Ser Lys Glu Lys Ile Ala Lys Met Glu
            180                 185                 190         
His Gly Pro Lys Ala Val Thr Ile Ala Asn Ser Pro Ser Lys Pro Ser
        195                 200                 205             
Glu Lys Asp Ser Val Val Ser Leu Glu Ser Gln Lys Thr Pro Ala Asp
    210                 215                 220                 
Pro Lys Leu Lys Thr Leu Ser Gln Thr Lys Lys Asn Lys Gly Ser Asp
225                 230                 235                 240 
Ser Ser Leu Ser Gly Asn Ser Asp Gly Gly Glu Glu Phe Cys Glu Glu
                245                 250                 255     
Glu Lys Glu Tyr Phe Asp Asp Ser Thr Glu Glu Arg Phe Tyr Lys Gln
            260                 265                 270         
Ser Ser Met Ser Glu Asp Ser Asp Ser Gly Asp Asp Phe Phe Ile Gly
        275                 280                 285             
Lys Val Arg Arg Thr Arg Lys Lys Glu Ser Ser Cys His Ser Ser Val
    290                 295                 300                 
Lys Glu Gln Lys Pro Leu Glu Lys Val Phe Leu Lys Glu Asp Thr Gly
305                 310                 315                 320 
Glu Thr His Gly Asp Thr Arg Asn Asp Lys Ile Lys Pro Ser Thr Glu
                325                 330                 335     
Thr Arg Lys Leu Glu Ser Val Phe Ser His Ser Leu Ser Gly Ser Lys
            340                 345                 350         
Ser Ser Arg Arg Asn Phe Lys Glu Gln Ala Pro Lys Thr Arg Ser Leu
        355                 360                 365             
Asp Phe Pro Gln Asn Glu Pro Gln Ile Lys Asn Gln Phe Asn Lys Lys
    370                 375                 380                 
Leu Ser Gly Arg Leu Glu Asn Thr Lys Gln Gln Leu Gln Leu Pro Leu
385                 390                 395                 400 
His Pro Ser Trp Glu Ala Ser Arg Arg Arg Lys Glu Gln Gln Ser Asn
                405                 410                 415     
Ile Ala Val Phe Gln Gly Lys Lys Asn Tyr Val
            420                 425         


<210> 2519
<211> 276
<212> PRT
<213> Homo sapiens

<400> 2519
Met Ala Ala Asp Glu Ser Ser Gln Asn Thr Leu Arg Leu Gln Phe Lys
 1               5                  10                  15      
Ala Met Gln Glu Met Gln His Lys Arg Leu Gln Lys Gln Met Glu Lys
            20                  25                  30          
Lys Arg Glu Lys Glu Leu Ser Leu Lys Ser Arg Ala Asp Asp Gln Glu
        35                  40                  45              
Glu Pro Leu Glu Val Ser Asp Gly Leu Ser Leu Leu His Ala Gly Glu
    50                  55                  60                  
Pro Asn Ser Lys Asn Ser Phe Glu Lys Arg Val Leu Glu Asp Glu Ile
65                  70                  75                  80  
Glu His Leu Arg Asn Glu Leu Arg Glu Thr Val Asp Glu Asn Gly Arg
                85                  90                  95      
Leu Tyr Lys Leu Leu Lys Glu Arg Asp Phe Glu Ile Lys His Leu Lys
            100                 105                 110         
Lys Lys Ile Glu Glu Asp Arg Phe Ala Phe Thr Gly Thr Ala Gly Val
        115                 120                 125             
Ala Gly Asp Val Val Ala Thr Lys Ile Val Glu Leu Ser Lys Lys Asn
    130                 135                 140                 
Arg Leu Leu Met Ala Glu Ser Glu Gly Ala Lys Thr Arg Val Lys Gln
145                 150                 155                 160 
Leu Thr Asn Arg Ile Gln Glu Leu Glu Arg Glu Leu Gln Thr Ala Leu
                165                 170                 175     
Thr Arg Leu Ser Ala Lys Gly Ala Thr Asp Ala Gly Ala Lys Pro Pro
            180                 185                 190         
Arg Ala Gln Met Gly Asp Arg Ala Leu Leu Glu Thr Pro Glu Val Lys
        195                 200                 205             
Ala Leu Gln Asp Arg Leu Val Ala Thr Asn Leu Lys Met Ser Asp Leu
    210                 215                 220                 
Arg Asn Gln Ile Gln Ser Val Lys Gln Glu Leu Arg Met Ala Gln Lys
225                 230                 235                 240 
Val Phe Gln Ser Gln Gly Leu Gly Leu Leu Val Trp Leu Gly Leu Asp
                245                 250                 255     
Leu Gly Arg Ala Arg Leu Ala Gln Trp Ile Pro Phe Trp Ser His Glu
            260                 265                 270         
Cys Ser Val Pro
        275     


<210> 2520
<211> 190
<212> PRT
<213> Homo sapiens

<400> 2520
Met Ala Gly Ser Arg Leu Glu Thr Val Gly Ser Ile Phe Ser Arg Thr
 1               5                  10                  15      
Arg Asp Leu Val Arg Ala Gly Val Leu Lys Glu Lys Pro Leu Trp Phe
            20                  25                  30          
Asp Val Tyr Asp Ala Phe Pro Pro Leu Arg Glu Pro Val Phe Gln Arg
        35                  40                  45              
Pro Arg Val Arg Tyr Gly Lys Ala Lys Ala Pro Ile Gln Asp Ile Trp
    50                  55                  60                  
Tyr His Glu Asp Arg Ile Arg Ala Lys Phe Tyr Ser Val Tyr Gly Ser
65                  70                  75                  80  
Gly Gln Arg Ala Phe Asp Leu Phe Asn Pro Asn Phe Lys Ser Thr Cys
                85                  90                  95      
Gln Arg Phe Val Glu Lys Tyr Thr Glu Leu Gln Lys Leu Gly Glu Thr
            100                 105                 110         
Asp Glu Glu Lys Leu Phe Val Glu Thr Gly Lys Ala Leu Leu Ala Glu
        115                 120                 125             
Gly Val Ile Leu Arg Arg Val Gly Glu Ala Arg Thr Gln His Gly Gly
    130                 135                 140                 
Ser His Val Ser Arg Lys Ser Glu His Leu Ser Val Arg Pro Gln Thr
145                 150                 155                 160 
Ala Leu Glu Glu Asn Glu Thr Gln Lys Glu Val Pro Gln Asp Gln His
                165                 170                 175     
Leu Glu Ala Pro Ala Asp Gln Ser Lys Gly Leu Leu Pro Pro
            180                 185                 190 


<210> 2521
<211> 201
<212> PRT
<213> Homo sapiens

<400> 2521
Met Ala Ala Arg Thr Ala Phe Gly Ala Val Cys Arg Arg Leu Trp Gln
 1               5                  10                  15      
Gly Leu Gly Asn Phe Ser Val Asn Thr Ser Lys Gly Asn Thr Ala Lys
            20                  25                  30          
Asn Gly Gly Leu Leu Leu Ser Thr Asn Met Lys Trp Val Gln Phe Ser
        35                  40                  45              
Asn Leu His Val Asp Val Pro Lys Asp Leu Thr Lys Pro Val Val Thr
    50                  55                  60                  
Ile Ser Asp Glu Pro Asp Ile Leu Tyr Lys Arg Leu Ser Val Leu Val
65                  70                  75                  80  
Lys Gly His Asp Lys Ala Val Leu Asp Ser Tyr Glu Tyr Phe Ala Val
                85                  90                  95      
Leu Ala Ala Lys Glu Leu Gly Ile Ser Ile Lys Val His Glu Pro Pro
            100                 105                 110         
Arg Lys Ile Glu Arg Phe Thr Leu Leu Gln Ser Val His Ile Tyr Lys
        115                 120                 125             
Lys His Arg Val Gln Tyr Glu Met Arg Thr Leu Tyr Arg Cys Leu Glu
    130                 135                 140                 
Leu Glu His Leu Thr Gly Ser Thr Ala Asp Val Tyr Leu Glu Tyr Ile
145                 150                 155                 160 
Gln Arg Asn Leu Pro Glu Gly Val Ala Met Glu Val Thr Lys Thr Gln
                165                 170                 175     
Leu Glu Gln Leu Pro Glu His Ile Lys Glu Pro Ile Trp Glu Thr Leu
            180                 185                 190         
Ser Glu Glu Lys Glu Glu Ser Lys Ser
        195                 200     


<210> 2522
<211> 440
<212> PRT
<213> Homo sapiens

<400> 2522
Met Gly Gln Ser Gln Ser Gly Gly His Gly Pro Gly Gly Gly Lys Lys
 1               5                  10                  15      
Asp Asp Lys Asp Lys Lys Lys Lys Tyr Glu Pro Pro Val Pro Thr Arg
            20                  25                  30          
Val Gly Lys Lys Lys Lys Lys Thr Lys Gly Pro Asp Ala Ala Ser Lys
        35                  40                  45              
Leu Pro Leu Val Thr Pro His Thr Gln Cys Arg Leu Lys Leu Leu Lys
    50                  55                  60                  
Leu Glu Arg Ile Lys Asp Tyr Leu Leu Met Glu Glu Glu Phe Ile Arg
65                  70                  75                  80  
Asn Gln Glu Gln Met Lys Pro Leu Glu Glu Lys Gln Glu Glu Glu Arg
                85                  90                  95      
Ser Lys Val Asp Asp Leu Arg Gly Thr Pro Met Ser Val Gly Thr Leu
            100                 105                 110         
Glu Glu Ile Ile Asp Asp Asn Arg Ala Ile Val Ser Thr Ser Val Gly
        115                 120                 125             
Ser Glu His Tyr Val Ser Ile Leu Ser Phe Val Asp Lys Asp Leu Leu
    130                 135                 140                 
Glu Pro Gly Cys Ser Val Leu Leu Asn His Lys Val His Ala Val Ile
145                 150                 155                 160 
Gly Val Leu Met Asp Asp Thr Asp Pro Leu Val Thr Val Met Lys Val
                165                 170                 175     
Glu Lys Ala Pro Gln Glu Thr Tyr Ala Asp Ile Gly Gly Leu Asp Asn
            180                 185                 190         
Gln Ile Gln Glu Ile Lys Glu Ser Val Glu Leu Pro Leu Thr His Pro
        195                 200                 205             
Glu Tyr Tyr Glu Glu Met Gly Ile Lys Pro Pro Lys Gly Val Ile Leu
    210                 215                 220                 
Tyr Gly Pro Pro Gly Thr Gly Lys Thr Leu Leu Ala Lys Ala Val Ala
225                 230                 235                 240 
Asn Gln Thr Ser Ala Thr Phe Leu Arg Val Val Gly Ser Glu Leu Ile
                245                 250                 255     
Gln Lys Tyr Leu Gly Asp Gly Pro Lys Leu Val Arg Glu Leu Phe Arg
            260                 265                 270         
Val Ala Glu Glu His Ala Pro Ser Ile Val Phe Ile Asp Glu Ile Asp
        275                 280                 285             
Ala Ile Gly Thr Lys Arg Tyr Asp Ser Asn Ser Gly Gly Glu Arg Glu
    290                 295                 300                 
Ile Gln Arg Thr Met Leu Glu Leu Leu Asn Gln Leu Asp Gly Phe Asp
305                 310                 315                 320 
Ser Arg Gly Asp Val Lys Val Ile Met Ala Thr Asn Arg Ile Glu Thr
                325                 330                 335     
Leu Asp Pro Ala Leu Ile Arg Pro Gly Arg Ile Asp Arg Lys Ile Glu
            340                 345                 350         
Phe Pro Leu Pro Asp Glu Lys Thr Lys Lys Arg Ile Phe Gln Ile His
        355                 360                 365             
Thr Ser Arg Met Thr Leu Ala Asp Asp Val Thr Leu Asp Asp Leu Ile
    370                 375                 380                 
Met Ala Lys Asp Asp Leu Ser Gly Ala Asp Ile Lys Ala Ile Cys Thr
385                 390                 395                 400 
Glu Ala Gly Leu Met Ala Leu Arg Glu Arg Arg Met Lys Val Thr Asn
                405                 410                 415     
Glu Asp Phe Lys Lys Ser Lys Glu Asn Val Leu Tyr Lys Lys Gln Glu
            420                 425                 430         
Gly Thr Pro Glu Gly Leu Tyr Leu
        435                 440 


<210> 2523
<211> 500
<212> PRT
<213> Homo sapiens

<400> 2523
Met Ala Tyr Ala Ala Arg Thr Met Gly Lys Leu Ala Tyr Glu Gly Val
 1               5                  10                  15      
Ser Ser Arg Lys Thr Tyr Phe Ser Glu Glu Asp Val Cys Gly Cys Leu
            20                  25                  30          
Glu Ala Gly Ile Arg Thr Glu Glu Glu Phe Gln Leu Leu His Ile Phe
        35                  40                  45              
Arg Arg Asp Ala Leu Arg Phe Phe Leu Ala Pro Cys Val Glu Pro Gly
    50                  55                  60                  
Arg Ala Gly Thr Phe Val Phe Thr Val Pro Ala Met Gln Glu Tyr Leu
65                  70                  75                  80  
Ala Ala Leu Tyr Ile Val Leu Gly Leu Arg Lys Thr Thr Leu Gln Lys
                85                  90                  95      
Val Gly Lys Glu Val Ala Glu Leu Val Gly Arg Val Gly Glu Asp Val
            100                 105                 110         
Ser Leu Val Leu Gly Ile Met Ala Lys Leu Leu Pro Leu Arg Ala Leu
        115                 120                 125             
Pro Leu Leu Phe Asn Leu Ile Lys Val Val Pro Arg Val Phe Gly Arg
    130                 135                 140                 
Met Val Gly Lys Ser Arg Glu Ala Val Ala Gln Ala Met Val Leu Glu
145                 150                 155                 160 
Met Phe Arg Glu Glu Asp Tyr Tyr Asn Asp Asp Val Leu Asp Gln Met
                165                 170                 175     
Gly Ala Ser Ile Leu Gly Val Glu Gly Pro Arg Arg His Pro Asp Glu
            180                 185                 190         
Pro Pro Glu Asp Glu Val Phe Glu Leu Phe Pro Met Phe Met Gly Gly
        195                 200                 205             
Leu Leu Ser Ala His Asn Arg Ala Val Leu Ala Gln Leu Gly Cys Pro
    210                 215                 220                 
Ile Lys Asn Leu Asp Ala Leu Glu Asn Ala Gln Ala Ile Lys Lys Lys
225                 230                 235                 240 
Leu Gly Lys Leu Gly Arg Gln Val Leu Pro Pro Ser Glu Leu Leu Asp
                245                 250                 255     
His Leu Phe Phe His Tyr Glu Phe Gln Asn Gln Arg Phe Ser Ala Glu
            260                 265                 270         
Val Leu Ser Ser Leu Arg Gln Leu Asn Leu Ala Gly Val Arg Met Thr
        275                 280                 285             
Pro Val Lys Cys Thr Val Val Ala Ala Val Leu Gly Ser Gly Arg His
    290                 295                 300                 
Ala Leu Asp Glu Val Asn Leu Ala Ser Cys Gln Leu Asp Pro Ala Gly
305                 310                 315                 320 
Leu Arg Thr Leu Leu Pro Val Phe Leu Arg Ala Arg Lys Leu Gly Leu
                325                 330                 335     
Gln Leu Asn Ser Leu Gly Pro Glu Ala Cys Lys Asp Leu Arg Asp Leu
            340                 345                 350         
Leu Leu His Asp Gln Cys Gln Ile Thr Thr Leu Arg Leu Ser Asn Asn
        355                 360                 365             
Pro Leu Thr Glu Ala Gly Val Ala Val Leu Met Glu Gly Leu Ala Gly
    370                 375                 380                 
Asn Thr Ser Val Thr His Leu Ser Leu Leu His Thr Gly Leu Gly Asp
385                 390                 395                 400 
Glu Gly Leu Glu Leu Leu Ala Ala Gln Leu Asp Arg Asn Arg Gln Leu
                405                 410                 415     
Gln Glu Leu Asn Val Ala Tyr Asn Gly Ala Gly Asp Thr Ala Ala Leu
            420                 425                 430         
Ala Leu Ala Arg Ala Ala Arg Glu His Pro Ser Leu Glu Leu Leu Gln
        435                 440                 445             
Gly Val Ala Ile Gln Met Cys Trp Lys Leu Pro Leu Leu Pro Tyr Ala
    450                 455                 460                 
His Leu Trp Thr Pro Arg Met Pro Ser His Trp Cys Phe Leu Leu Ile
465                 470                 475                 480 
Leu Met Pro Pro Leu Pro Gln Trp Tyr Asp Gly Leu Val Ala Pro Arg
                485                 490                 495     
Gly Arg Cys Thr
            500 


<210> 2524
<211> 237
<212> PRT
<213> Homo sapiens

<400> 2524
Met Ala Ala Ala Ser Gly Ser Val Leu Gln Arg Cys Ile Val Ser Pro
 1               5                  10                  15      
Ala Gly Arg His Ser Ala Ser Leu Ile Phe Leu His Gly Ser Gly Asp
            20                  25                  30          
Ser Gly Gln Gly Leu Arg Met Trp Ile Lys Gln Val Leu Asn Gln Asp
        35                  40                  45              
Leu Thr Phe Gln His Ile Lys Ile Ile Tyr Pro Thr Ala Pro Pro Arg
    50                  55                  60                  
Ser Tyr Thr Pro Met Lys Gly Gly Ile Ser Asn Val Trp Phe Asp Arg
65                  70                  75                  80  
Phe Lys Ile Thr Asn Asp Cys Pro Glu His Leu Glu Ser Ile Asp Val
                85                  90                  95      
Met Cys Gln Val Leu Thr Asp Leu Ile Asp Glu Glu Val Lys Ser Gly
            100                 105                 110         
Ile Lys Lys Asn Arg Ile Leu Ile Gly Gly Phe Ser Met Gly Gly Cys
        115                 120                 125             
Met Ala Met His Leu Ala Tyr Arg Asn His Gln Asp Val Ala Gly Val
    130                 135                 140                 
Phe Ala Leu Ser Ser Phe Leu Asn Lys Ala Ser Ala Val Tyr Gln Ala
145                 150                 155                 160 
Leu Gln Lys Ser Asn Gly Val Leu Pro Glu Leu Phe Gln Cys His Gly
                165                 170                 175     
Thr Ala Asp Glu Leu Val Leu His Ser Trp Ala Glu Glu Thr Asn Ser
            180                 185                 190         
Met Leu Lys Ser Leu Gly Val Thr Thr Lys Phe His Ser Phe Pro Asn
        195                 200                 205             
Val Tyr His Glu Leu Ser Lys Thr Glu Leu Asp Ile Leu Lys Leu Trp
    210                 215                 220                 
Ile Leu Thr Lys Leu Pro Gly Glu Met Glu Lys Gln Lys
225                 230                 235         


<210> 2525
<211> 298
<212> PRT
<213> Homo sapiens

<400> 2525
Met Phe Ser Arg Ala Gly Val Ala Gly Leu Ser Ala Trp Thr Leu Gln
 1               5                  10                  15      
Pro Gln Trp Ile Gln Val Arg Asn Met Ala Thr Leu Lys Asp Ile Thr
            20                  25                  30          
Arg Arg Leu Lys Ser Ile Lys Asn Ile Gln Lys Ile Ala Lys Ser Met
        35                  40                  45              
Lys Met Val Ala Ala Ala Lys Tyr Ala Arg Ala Glu Arg Glu Leu Lys
    50                  55                  60                  
Pro Ala Arg Ile Tyr Gly Leu Gly Ser Leu Ala Leu Tyr Glu Lys Ala
65                  70                  75                  80  
Asp Ile Lys Gly Pro Glu Asp Lys Lys Lys His Leu Leu Ile Gly Val
                85                  90                  95      
Ser Ser Asp Arg Gly Leu Cys Gly Ala Ile His Ser Ser Ile Ala Lys
            100                 105                 110         
Gln Met Lys Ser Glu Val Ala Thr Leu Thr Ala Ala Gly Lys Glu Val
        115                 120                 125             
Met Leu Val Gly Ile Gly Asp Lys Ile Arg Gly Ile Leu Tyr Arg Thr
    130                 135                 140                 
His Ser Asp Gln Phe Leu Val Ala Phe Lys Glu Val Gly Arg Lys Pro
145                 150                 155                 160 
Pro Thr Phe Gly Asp Ala Ser Val Ile Ala Leu Glu Leu Leu Asn Ser
                165                 170                 175     
Gly Tyr Glu Phe Asp Glu Gly Ser Ile Ile Phe Asn Lys Phe Arg Ser
            180                 185                 190         
Val Ile Ser Tyr Lys Thr Glu Glu Lys Pro Ile Phe Ser Leu Asn Thr
        195                 200                 205             
Val Ala Ser Ala Asp Ser Met Ser Ile Tyr Asp Asp Ile Asp Ala Asp
    210                 215                 220                 
Val Leu Gln Asn Tyr Gln Glu Tyr Asn Leu Ala Asn Ile Ile Tyr Tyr
225                 230                 235                 240 
Ser Leu Lys Glu Ser Thr Thr Ser Glu Gln Ser Ala Arg Met Thr Ala
                245                 250                 255     
Met Asp Asn Ala Ser Lys Asn Ala Ser Glu Met Ile Asp Lys Leu Thr
            260                 265                 270         
Leu Thr Phe Asn Arg Thr Arg Gln Ala Val Ile Thr Lys Glu Leu Ile
        275                 280                 285             
Glu Ile Ile Ser Gly Ala Ala Ala Leu Asp
    290                 295             


<210> 2526
<211> 241
<212> PRT
<213> Homo sapiens

<400> 2526
Met Ser Gly Phe Gln Ile Asn Leu Asn Pro Leu Lys Glu Pro Leu Gly
 1               5                  10                  15      
Phe Ile Lys Val Leu Glu Trp Ile Ala Ser Ile Phe Ala Phe Ala Thr
            20                  25                  30          
Cys Gly Gly Phe Lys Gly Gln Thr Glu Ile Gln Val Asn Cys Pro Pro
        35                  40                  45              
Ala Val Thr Glu Asn Lys Thr Val Thr Ala Thr Phe Gly Tyr Pro Phe
    50                  55                  60                  
Arg Leu Asn Glu Ala Ser Phe Gln Pro Pro Pro Gly Val Asn Ile Cys
65                  70                  75                  80  
Asp Val Asn Trp Lys Asp Tyr Val Leu Ile Gly Asp Tyr Ser Ser Ser
                85                  90                  95      
Ala Gln Phe Tyr Val Thr Phe Ala Val Phe Val Phe Leu Tyr Cys Ile
            100                 105                 110         
Ala Ala Leu Leu Leu Tyr Val Gly Tyr Thr Ser Leu Tyr Leu Asp Ser
        115                 120                 125             
Arg Lys Leu Pro Met Ile Asp Phe Val Val Thr Leu Val Ala Thr Phe
    130                 135                 140                 
Leu Trp Leu Val Ser Thr Ser Ala Trp Ala Lys Ala Leu Thr Asp Ile
145                 150                 155                 160 
Lys Ile Ala Thr Gly His Asn Ile Ile Asp Glu Leu Pro Pro Cys Lys
                165                 170                 175     
Lys Lys Ala Val Leu Cys Tyr Phe Gly Ser Val Thr Ser Met Gly Ser
            180                 185                 190         
Leu Asn Val Ser Val Ile Phe Gly Phe Leu Asn Met Ile Leu Trp Gly
        195                 200                 205             
Gly Asn Ala Trp Phe Val Tyr Lys Glu Thr Ser Leu His Ser Pro Ser
    210                 215                 220                 
Asn Thr Ser Ala Pro His Ser Gln Gly Gly Ile Pro Pro Pro Thr Gly
225                 230                 235                 240 
Ile
    


<210> 2527
<211> 111
<212> PRT
<213> Homo sapiens

<400> 2527
Met Gly Leu Thr Glu Lys Leu Ile Phe Ser Leu Arg Asp Pro Ala Tyr
 1               5                  10                  15      
Ser Thr Phe Pro Pro Glu Gly Val Phe Val Asn Thr Leu Gly Leu Leu
            20                  25                  30          
Ile Leu Val Phe Gly Ala Leu Ile Phe Trp Ile Val Thr Arg Pro Gln
        35                  40                  45              
Trp Lys Arg Pro Lys Glu Pro Asn Ser Thr Ile Leu His Pro Asn Gly
    50                  55                  60                  
Gly Thr Glu Gln Gly Ala Arg Gly Ser Met Pro Ala Tyr Ser Gly Asn
65                  70                  75                  80  
Asn Met Asp Lys Ser Asp Ser Glu Leu Asn Asn Glu Val Ala Ala Arg
                85                  90                  95      
Lys Arg Asn Leu Ala Leu Asp Glu Ala Gly Gln Arg Ser Thr Met
            100                 105                 110     


<210> 2528
<211> 459
<212> PRT
<213> Homo sapiens

<400> 2528
Met Thr Val Glu Leu Trp Leu Arg Leu Arg Gly Lys Gly Leu Ala Met
 1               5                  10                  15      
Leu His Val Thr Arg Gly Val Trp Gly Ser Arg Val Arg Val Trp Pro
            20                  25                  30          
Leu Leu Pro Ala Leu Leu Gly Pro Pro Arg Ala Leu Ser Ser Leu Ala
        35                  40                  45              
Ala Lys Met Gly Glu Tyr Arg Lys Met Trp Asn Pro Arg Glu Pro Arg
    50                  55                  60                  
Asp Trp Ala Gln Gln Tyr Arg Glu Arg Phe Ile Pro Phe Ser Lys Glu
65                  70                  75                  80  
Gln Leu Leu Arg Leu Leu Ile Gln Glu Phe His Ser Ser Pro Ala Glu
                85                  90                  95      
Lys Ala Ala Leu Glu Ala Phe Ser Ala His Val Asp Phe Cys Thr Leu
            100                 105                 110         
Phe His Tyr His Gln Ile Leu Ala Arg Leu Gln Ala Leu Tyr Asp Pro
        115                 120                 125             
Ile Asn Pro Asp Arg Glu Thr Leu Asp Gln Pro Ser Leu Thr Asp Pro
    130                 135                 140                 
Gln Arg Leu Ser Asn Glu Gln Glu Val Leu Arg Ala Leu Glu Pro Leu
145                 150                 155                 160 
Leu Ala Gln Ala Asn Phe Ser Pro Leu Ser Glu Asp Thr Leu Ala Tyr
                165                 170                 175     
Ala Leu Val Val His His Pro Gln Asp Glu Val Gln Val Thr Val Asn
            180                 185                 190         
Leu Asp Gln Tyr Val Tyr Ile His Phe Trp Ala Leu Gly Gln Arg Val
        195                 200                 205             
Gly Gln Met Pro Leu Lys Ser Ser Val Gly Ser Arg Arg Gly Phe Phe
    210                 215                 220                 
Thr Lys Leu Pro Pro Ala Glu Arg Arg Tyr Phe Lys Arg Val Val Leu
225                 230                 235                 240 
Ala Ala Arg Thr Lys Arg Gly His Leu Val Leu Lys Ser Phe Lys Asp
                245                 250                 255     
Thr Pro Leu Glu Gly Leu Glu Gln Leu Leu Pro Glu Leu Lys Val Arg
            260                 265                 270         
Thr Pro Thr Leu Gln Arg Ala Leu Leu Asn Leu Met Leu Val Val Ser
        275                 280                 285             
Gly Val Ala Ile Phe Val Asn Val Gly Met Val Val Leu Thr Asp Leu
    290                 295                 300                 
Lys Val Ala Thr Ser Leu Leu Leu Leu Leu Phe Ala Ile Phe Met Gly
305                 310                 315                 320 
Leu Arg Ala Ser Lys Met Phe Gly Gln Arg Arg Ser Ala Gln Ala Leu
                325                 330                 335     
Glu Leu Ala His Met Leu Tyr Tyr Arg Ser Thr Ser Asn Asn Ser Glu
            340                 345                 350         
Leu Leu Ser Ala Leu Ala Leu Arg Ala Gln Asp Glu His Thr Lys Glu
        355                 360                 365             
Ala Leu Leu Ala His Ser Phe Leu Ala Arg Arg Pro Gly Gly Thr Gln
    370                 375                 380                 
Gly Ser Pro Glu Glu Thr Ser Arg Trp Leu Arg Ser Glu Val Glu Asn
385                 390                 395                 400 
Trp Leu Leu Ala Lys Ser Gly Cys Glu Val Thr Phe Asn Gly Thr Arg
                405                 410                 415     
Ala Leu Ala His Leu Gln Ala Leu Thr Pro Ser Met Gly Leu Tyr Pro
            420                 425                 430         
Pro Pro Gly Phe Pro Lys Leu Asp Pro Val Ala Pro Ile Thr Ser Glu
        435                 440                 445             
Pro Pro Gln Ala Thr Pro Ser Ser Asn Ile Ser
    450                 455                 


<210> 2529
<211> 459
<212> PRT
<213> Homo sapiens

<400> 2529
Met Thr Val Glu Leu Trp Leu Arg Leu Arg Gly Lys Gly Leu Ala Met
 1               5                  10                  15      
Leu His Val Thr Arg Gly Val Trp Gly Ser Arg Val Arg Val Trp Pro
            20                  25                  30          
Leu Leu Pro Ala Leu Leu Gly Pro Pro Arg Ala Leu Ser Ser Leu Ala
        35                  40                  45              
Ala Lys Met Gly Glu Tyr Arg Lys Met Trp Asn Pro Arg Glu Pro Arg
    50                  55                  60                  
Asp Trp Ala Gln Gln Tyr Arg Glu Arg Phe Ile Pro Phe Ser Lys Glu
65                  70                  75                  80  
Gln Leu Leu Arg Leu Leu Ile Gln Glu Phe His Ser Ser Pro Ala Glu
                85                  90                  95      
Lys Ala Ala Leu Glu Ala Phe Ser Ala His Val Asp Phe Cys Thr Leu
            100                 105                 110         
Phe His Tyr His Gln Ile Leu Ala Arg Leu Gln Ala Leu Tyr Asp Pro
        115                 120                 125             
Ile Asn Pro Asp Arg Glu Thr Leu Asp Gln Pro Ser Leu Thr Asp Pro
    130                 135                 140                 
Gln Arg Leu Ser Asn Glu Gln Glu Val Leu Arg Ala Leu Glu Pro Leu
145                 150                 155                 160 
Leu Ala Gln Ala Asn Phe Ser Pro Leu Ser Glu Asp Thr Leu Ala Tyr
                165                 170                 175     
Ala Leu Val Val His His Pro Gln Asp Glu Val Gln Val Thr Val Asn
            180                 185                 190         
Leu Asp Gln Tyr Val Tyr Ile His Phe Trp Ala Leu Gly Gln Arg Val
        195                 200                 205             
Gly Gln Met Pro Leu Lys Ser Ser Val Gly Ser Arg Arg Gly Phe Phe
    210                 215                 220                 
Thr Lys Leu Pro Pro Ala Glu Arg Arg Tyr Phe Lys Arg Val Val Leu
225                 230                 235                 240 
Ala Ala Arg Thr Lys Arg Gly His Leu Val Leu Lys Ser Phe Lys Asp
                245                 250                 255     
Thr Pro Leu Glu Gly Leu Glu Gln Leu Leu Pro Glu Leu Lys Val Arg
            260                 265                 270         
Thr Pro Thr Leu Gln Arg Ala Leu Leu Asn Leu Met Leu Val Val Ser
        275                 280                 285             
Gly Val Ala Ile Phe Val Asn Val Gly Met Val Val Leu Thr Asp Leu
    290                 295                 300                 
Lys Val Ala Thr Ser Leu Leu Leu Leu Leu Phe Ala Ile Phe Met Gly
305                 310                 315                 320 
Leu Arg Ala Ser Lys Met Phe Gly Gln Arg Arg Ser Ala Gln Ala Leu
                325                 330                 335     
Glu Leu Ala His Met Leu Tyr Tyr Arg Ser Thr Ser Asn Asn Ser Glu
            340                 345                 350         
Leu Leu Ser Ala Leu Ala Leu Arg Ala Gln Asp Glu His Thr Lys Glu
        355                 360                 365             
Ala Leu Leu Ala His Ser Phe Leu Ala Arg Arg Pro Gly Gly Thr Gln
    370                 375                 380                 
Gly Ser Pro Glu Glu Thr Ser Arg Trp Leu Arg Ser Glu Val Glu Asn
385                 390                 395                 400 
Trp Leu Leu Ala Lys Ser Gly Cys Glu Val Thr Phe Asn Gly Thr Arg
                405                 410                 415     
Ala Leu Ala His Leu Gln Ala Leu Thr Pro Ser Met Gly Leu Tyr Pro
            420                 425                 430         
Pro Pro Gly Phe Pro Lys Leu Asp Pro Val Ala Pro Ile Thr Ser Glu
        435                 440                 445             
Pro Pro Gln Ala Thr Pro Ser Ser Asn Ile Ser
    450                 455                 


<210> 2530
<211> 199
<212> PRT
<213> Homo sapiens

<400> 2530
Ala Pro Gly Arg Leu Ala Ser Arg Pro Pro Pro Pro Pro Ala Arg Arg
 1               5                  10                  15      
Trp Arg Leu Ala Ala Pro Arg Tyr Ser Ser Ala Ser Gly Pro Ser Gly
            20                  25                  30          
Pro Ala Ala Arg Leu Cys Ala Glu Thr Gln Gly Glu Ala Pro Arg Gly
        35                  40                  45              
Pro Arg Ala Val Gly Gly Ser Gly Gly Ala Gly Glu Pro Arg Trp Ser
    50                  55                  60                  
Arg Gly Pro Ala Gln Arg Glu Arg Leu Leu Gly Cys Ser Cys Cys Phe
65                  70                  75                  80  
Pro Ser Phe Phe Thr Gly Thr Cys Ser Phe Arg Thr Ser Trp Ser Ala
                85                  90                  95      
Phe Thr Leu Glu Leu Thr Ser Ser Ile Pro Ala Pro Leu Pro Pro Pro
            100                 105                 110         
Pro Ala Ala Leu Ser Leu Ser Gln Gln Gln Gly Lys Ser Arg Arg Lys
        115                 120                 125             
Glu Ala Ser Thr Pro Leu Thr Pro Ala Glu Ala Pro Ala Tyr Ser Arg
    130                 135                 140                 
Ala Arg Pro Arg Arg Gln Gly Ser Pro Ser Ala Gly Pro Glu Ala Pro
145                 150                 155                 160 
Leu Ala Thr Asp Glu Pro Pro Pro Gln Arg Arg Ser Gly Ile Arg Gly
                165                 170                 175     
Gly Ser Ala Asn Ile Arg Ser Leu Gln Pro Ser Ser Leu Arg Pro Ser
            180                 185                 190         
Ala His Arg Gly Ser Ala Leu
        195                 


<210> 2531
<211> 423
<212> PRT
<213> Homo sapiens

<400> 2531
Met Ala Thr Ala Thr Arg Leu Leu Gly Cys Arg Val Ala Ser Trp Arg
 1               5                  10                  15      
Leu Arg Pro Pro Leu Ala Gly Phe Val Ser Gln Arg Ala His Ser Leu
            20                  25                  30          
Leu Pro Val Asp Asp Ala Ile Asn Gly Leu Ser Glu Glu Gln Arg Gln
        35                  40                  45              
Leu Arg Gln Thr Met Ala Lys Phe Leu Gln Glu His Leu Ala Pro Lys
    50                  55                  60                  
Ala Gln Glu Ile Asp Arg Ser Asn Glu Phe Lys Asn Leu Arg Glu Phe
65                  70                  75                  80  
Trp Lys Gln Leu Gly Asn Leu Gly Val Leu Gly Ile Thr Ala Pro Val
                85                  90                  95      
Gln Tyr Gly Gly Ser Gly Leu Gly Tyr Leu Glu His Val Leu Val Met
            100                 105                 110         
Glu Glu Ile Ser Arg Ala Ser Gly Ala Val Gly Leu Ser Tyr Gly Ala
        115                 120                 125             
His Ser Asn Leu Cys Ile Asn Gln Leu Val Arg Asn Gly Asn Glu Ala
    130                 135                 140                 
Gln Lys Glu Lys Tyr Leu Pro Lys Leu Ile Ser Gly Glu Tyr Ile Gly
145                 150                 155                 160 
Ala Leu Ala Met Ser Glu Pro Asn Ala Gly Ser Asp Val Val Ser Met
                165                 170                 175     
Lys Leu Lys Ala Glu Lys Lys Gly Asn His Tyr Ile Leu Asn Gly Asn
            180                 185                 190         
Lys Phe Trp Ile Thr Asn Gly Pro Asp Ala Asp Val Leu Ile Val Tyr
        195                 200                 205             
Ala Lys Thr Asp Leu Ala Ala Val Pro Ala Ser Arg Gly Ile Thr Ala
    210                 215                 220                 
Phe Ile Val Glu Lys Gly Met Pro Gly Phe Ser Thr Ser Lys Lys Leu
225                 230                 235                 240 
Asp Lys Leu Gly Met Arg Gly Ser Asn Thr Cys Glu Leu Ile Phe Glu
                245                 250                 255     
Asp Cys Lys Ile Pro Ala Ala Asn Ile Leu Gly His Glu Asn Lys Gly
            260                 265                 270         
Val Tyr Val Leu Met Ser Gly Leu Asp Leu Glu Arg Leu Val Leu Ala
        275                 280                 285             
Gly Gly Pro Leu Gly Leu Met Gln Ala Val Leu Asp His Thr Ile Pro
    290                 295                 300                 
Tyr Leu His Val Arg Glu Ala Phe Gly Gln Lys Ile Gly His Phe Gln
305                 310                 315                 320 
Leu Met Gln Gly Lys Met Ala Asp Met Tyr Thr Arg Leu Met Ala Cys
                325                 330                 335     
Arg Gln Tyr Val Tyr Asn Val Ala Lys Ala Cys Asp Glu Gly His Cys
            340                 345                 350         
Thr Ala Lys Asp Cys Ala Gly Val Ile Leu Tyr Ser Ala Glu Cys Ala
        355                 360                 365             
Thr Gln Val Ala Leu Asp Gly Ile Gln Cys Phe Gly Gly Asn Gly Tyr
    370                 375                 380                 
Ile Asn Asp Phe Pro Met Gly Arg Phe Leu Arg Asp Ala Lys Leu Tyr
385                 390                 395                 400 
Glu Ile Gly Ala Gly Thr Ser Glu Val Arg Arg Leu Val Ile Gly Arg
                405                 410                 415     
Ala Phe Asn Ala Asp Phe His
            420             


<210> 2532
<211> 690
<212> PRT
<213> Homo sapiens

<400> 2532
Met Thr Asp Thr Val Phe Ser Asn Ser Ser Asn Arg Trp Met Tyr Pro
 1               5                  10                  15      
Ser Asp Arg Pro Leu Gln Ser Lys Leu Gln Ala Gly Trp Ser Val His
            20                  25                  30          
Pro Gly Gly Gln Pro Asp Arg Gln Arg Lys Gln Glu Glu Leu Thr Asp
        35                  40                  45              
Glu Glu Lys Glu Ile Ile Asn Arg Val Ile Ala Arg Ala Glu Lys Met
    50                  55                  60                  
Glu Glu Met Glu Gln Glu Arg Ile Gly Arg Leu Val Asp Arg Leu Glu
65                  70                  75                  80  
Asn Met Arg Lys Asn Val Ala Gly Asp Gly Val Asn Arg Cys Ile Leu
                85                  90                  95      
Cys Gly Glu Gln Leu Gly Met Leu Gly Ser Ala Cys Val Val Cys Glu
            100                 105                 110         
Asp Cys Lys Lys Asn Val Cys Thr Lys Cys Gly Val Glu Thr Asn Asn
        115                 120                 125             
Arg Leu His Ser Val Trp Leu Cys Lys Ile Cys Ile Glu Gln Arg Glu
    130                 135                 140                 
Val Trp Lys Arg Ser Gly Ala Trp Phe Phe Lys Gly Phe Pro Lys Gln
145                 150                 155                 160 
Val Leu Pro Gln Pro Met Pro Ile Lys Lys Thr Lys Pro Gln Gln Pro
                165                 170                 175     
Val Ser Glu Pro Ala Ala Pro Glu Gln Pro Ala Pro Glu Pro Lys His
            180                 185                 190         
Pro Ala Arg Ala Pro Ala Arg Gly Asp Ser Glu Asp Arg Arg Gly Pro
        195                 200                 205             
Gly Gln Lys Thr Gly Pro Asp Pro Ala Ser Ala Pro Gly Arg Gly Asn
    210                 215                 220                 
Tyr Gly Pro Pro Val Arg Arg Ala Ser Glu Ala Arg Met Ser Ser Ser
225                 230                 235                 240 
Ser Arg Asp Ser Glu Ser Trp Asp His Ser Gly Gly Ala Gly Asp Ser
                245                 250                 255     
Ser Arg Ser Pro Ala Gly Leu Arg Arg Ala Asn Ser Val Gln Ala Ser
            260                 265                 270         
Arg Pro Ala Pro Gly Ser Val Gln Ser Pro Ala Pro Pro Gln Pro Gly
        275                 280                 285             
Gln Pro Gly Thr Pro Gly Gly Ser Arg Pro Gly Pro Gly Pro Ala Gly
    290                 295                 300                 
Arg Phe Pro Asp Gln Lys Pro Glu Val Ala Pro Ser Asp Pro Gly Thr
305                 310                 315                 320 
Thr Ala Pro Pro Arg Glu Glu Arg Thr Gly Gly Val Gly Gly Tyr Pro
                325                 330                 335     
Ala Val Gly Ala Arg Glu Asp Arg Met Ser His Pro Ser Gly Pro Tyr
            340                 345                 350         
Ser Gln Ala Ser Ala Ala Ala Pro Gln Pro Ala Ala Ala Arg Gln Pro
        355                 360                 365             
Pro Pro Pro Glu Glu Glu Glu Glu Glu Ala Asn Ser Tyr Asp Ser Asp
    370                 375                 380                 
Glu Ala Thr Thr Leu Gly Ala Leu Glu Phe Ser Leu Leu Tyr Asp Gln
385                 390                 395                 400 
Asp Asn Ser Ser Leu Gln Cys Thr Ile Ile Lys Ala Lys Gly Leu Lys
                405                 410                 415     
Pro Met Asp Ser Asn Gly Leu Ala Asp Pro Tyr Val Lys Leu His Leu
            420                 425                 430         
Leu Pro Gly Ala Ser Lys Ser Asn Lys Leu Arg Thr Lys Thr Leu Arg
        435                 440                 445             
Asn Thr Arg Asn Pro Ile Trp Asn Glu Thr Leu Val Tyr His Gly Ile
    450                 455                 460                 
Thr Asp Glu Asp Met Gln Arg Lys Thr Leu Arg Ile Ser Val Cys Asp
465                 470                 475                 480 
Glu Asp Lys Phe Gly His Asn Glu Phe Ile Gly Glu Thr Arg Phe Ser
                485                 490                 495     
Leu Lys Lys Leu Lys Pro Asn Gln Arg Lys Asn Phe Asn Ile Cys Leu
            500                 505                 510         
Glu Arg Val Ile Pro Met Lys Arg Ala Gly Thr Thr Gly Ser Ala Arg
        515                 520                 525             
Gly Met Ala Leu Tyr Glu Glu Glu Gln Val Glu Arg Val Gly Asp Ile
    530                 535                 540                 
Glu Glu Arg Gly Lys Ile Leu Val Ser Leu Met Tyr Ser Thr Gln Gln
545                 550                 555                 560 
Gly Gly Leu Ile Val Gly Ile Ile Arg Cys Val His Leu Ala Ala Met
                565                 570                 575     
Asp Ala Asn Gly Tyr Ser Asp Pro Phe Val Lys Leu Trp Leu Lys Pro
            580                 585                 590         
Asp Met Gly Lys Lys Ala Lys His Lys Thr Gln Ile Lys Lys Lys Thr
        595                 600                 605             
Leu Asn Pro Glu Phe Asn Glu Glu Phe Phe Tyr Asp Ile Lys His Ser
    610                 615                 620                 
Asp Leu Ala Lys Lys Ser Leu Asp Ile Ser Val Trp Asp Tyr Asp Ile
625                 630                 635                 640 
Gly Lys Ser Asn Asp Tyr Ile Gly Gly Cys Gln Leu Gly Ile Ser Ala
                645                 650                 655     
Lys Gly Glu Arg Leu Lys His Trp Tyr Glu Cys Leu Lys Asn Lys Asp
            660                 665                 670         
Lys Lys Ile Glu Arg Trp His Gln Leu Gln Asn Glu Asn His Val Ser
        675                 680                 685             
Ser Asp
    690 


<210> 2533
<211> 328
<212> PRT
<213> Homo sapiens

<400> 2533
Met Ala Ala Gly Ile Val Ala Ser Arg Arg Leu Arg Asp Leu Leu Thr
 1               5                  10                  15      
Arg Arg Leu Thr Gly Ser Asn Tyr Pro Gly Leu Ser Ile Ser Leu Arg
            20                  25                  30          
Leu Thr Gly Ser Ser Ala Gln Glu Ala Ala Ser Gly Val Ala Leu Gly
        35                  40                  45              
Glu Ala Pro Asp His Ser Tyr Glu Ser Leu Arg Val Thr Ser Ala Gln
    50                  55                  60                  
Lys His Val Leu His Val Gln Leu Asn Arg Pro Asn Lys Arg Asn Ala
65                  70                  75                  80  
Met Asn Lys Val Phe Trp Arg Glu Met Val Glu Cys Phe Asn Lys Ile
                85                  90                  95      
Ser Arg Asp Ala Asp Cys Arg Ala Val Val Ile Ser Gly Ala Gly Lys
            100                 105                 110         
Met Phe Thr Ala Gly Ile Asp Leu Met Asp Met Ala Ser Asp Ile Leu
        115                 120                 125             
Gln Pro Lys Gly Asp Asp Val Ala Arg Ile Ser Trp Tyr Leu Arg Asp
    130                 135                 140                 
Ile Ile Thr Arg Tyr Gln Glu Thr Phe Asn Val Ile Glu Arg Cys Pro
145                 150                 155                 160 
Lys Pro Val Ile Ala Ala Val His Gly Gly Cys Ile Gly Gly Gly Val
                165                 170                 175     
Asp Leu Val Thr Ala Cys Asp Ile Arg Tyr Cys Ala Gln Asp Ala Phe
            180                 185                 190         
Phe Gln Val Lys Glu Val Asp Val Gly Leu Ala Ala Asp Val Gly Thr
        195                 200                 205             
Leu Gln Arg Leu Pro Lys Val Ile Gly Asn Gln Ser Leu Val Asn Glu
    210                 215                 220                 
Leu Ala Phe Thr Ala Arg Lys Met Met Ala Asp Glu Ala Leu Gly Ser
225                 230                 235                 240 
Gly Leu Val Ser Arg Val Phe Pro Asp Lys Glu Val Met Leu Asp Ala
                245                 250                 255     
Ala Leu Ala Leu Ala Ala Glu Ile Ser Ser Lys Ser Pro Val Ala Val
            260                 265                 270         
Gln Ser Thr Lys Val Asn Leu Leu Tyr Ser Arg Asp His Ser Val Ala
        275                 280                 285             
Glu Ser Leu Asn Tyr Val Ala Ser Trp Asn Met Ser Met Leu Gln Thr
    290                 295                 300                 
Gln Asp Leu Val Lys Ser Val Gln Ala Thr Thr Glu Asn Lys Glu Leu
305                 310                 315                 320 
Lys Thr Val Thr Phe Ser Lys Leu
                325             


<210> 2534
<211> 169
<212> PRT
<213> Homo sapiens

<400> 2534
Gly Gln Gln Glu Glu Pro Glu Thr Ile Pro Glu Arg Thr Pro Ala Asp
 1               5                  10                  15      
Leu Glu Phe Ser Arg Leu Arg Phe Arg Glu Phe Val Tyr Gln Glu Ala
            20                  25                  30          
Ala Gly Pro His Gln Thr Leu Ala Arg Leu His Glu Leu Cys Arg Gln
        35                  40                  45              
Trp Leu Met Pro Glu Ala Cys Ser Lys Glu Gln Met Leu Glu Leu Leu
    50                  55                  60                  
Val Leu Glu Gln Phe Leu Gly Ile Leu Pro Asp Lys Val Arg Pro Trp
65                  70                  75                  80  
Val Val Ala Gln Tyr Pro Glu Ser Cys Lys Lys Ala Ala Ser Leu Val
                85                  90                  95      
Glu Gly Leu Ala Asp Val Leu Glu Glu Pro Gly Met Leu Leu Gly Ser
            100                 105                 110         
Pro Ala Gly Ser Ser Ser Ile Leu Ser Asp Gly Val Tyr Glu Arg His
        115                 120                 125             
Met Asp Pro Leu Leu Leu Pro Gly Glu Leu Ala Ser Pro Ser Gln Ala
    130                 135                 140                 
Leu Gly Ala Gly Glu Ile Pro Ala Pro Ser Glu Thr Arg Glu Cys Pro
145                 150                 155                 160 
Ala Ser Leu Ala Ala Ser Ala Gly Pro
                165                 


<210> 2535
<211> 323
<212> PRT
<213> Homo sapiens

<400> 2535
Met Ala Ala Ala Ala Leu Pro Ala Trp Leu Ser Leu Gln Ser Arg Ala
 1               5                  10                  15      
Arg Thr Leu Arg Ala Phe Ser Thr Ala Val Tyr Ser Ala Thr Pro Val
            20                  25                  30          
Pro Thr Pro Ser Leu Pro Glu Arg Thr Pro Gly Asn Glu Arg Pro Pro
        35                  40                  45              
Arg Arg Lys Ala Leu Pro Pro Arg Thr Glu Lys Met Ala Val Asp Gln
    50                  55                  60                  
Asp Trp Pro Ser Val Tyr Pro Val Ala Ala Pro Phe Lys Pro Ser Ala
65                  70                  75                  80  
Val Pro Leu Pro Val Arg Met Gly Tyr Pro Val Lys Lys Gly Val Pro
                85                  90                  95      
Met Ala Lys Glu Gly Asn Leu Glu Leu Leu Lys Ile Pro Asn Phe Leu
            100                 105                 110         
His Leu Thr Pro Val Ala Ile Lys Lys His Cys Glu Ala Leu Lys Asp
        115                 120                 125             
Phe Cys Thr Glu Trp Pro Ala Ala Leu Asp Ser Asp Glu Lys Cys Glu
    130                 135                 140                 
Lys His Phe Pro Ile Glu Ile Asp Ser Thr Asp Tyr Val Ser Ser Gly
145                 150                 155                 160 
Pro Ser Val Arg Asn Pro Arg Ala Arg Val Val Val Leu Arg Val Lys
                165                 170                 175     
Leu Ser Ser Leu Asn Leu Asp Asp His Ala Lys Lys Lys Leu Ile Lys
            180                 185                 190         
Leu Val Gly Glu Arg Tyr Cys Lys Thr Thr Asp Val Leu Thr Ile Lys
        195                 200                 205             
Thr Asp Arg Cys Pro Leu Arg Arg Gln Asn Tyr Asp Tyr Ala Val Tyr
    210                 215                 220                 
Leu Leu Thr Val Leu Tyr His Glu Ser Trp Asn Thr Glu Glu Trp Glu
225                 230                 235                 240 
Lys Ser Lys Thr Glu Ala Asp Met Glu Glu Tyr Ile Trp Glu Asn Ser
                245                 250                 255     
Ser Ser Glu Arg Asn Ile Leu Glu Thr Leu Leu Gln Met Lys Ala Ala
            260                 265                 270         
Glu Lys Asn Met Glu Ile Asn Lys Glu Glu Leu Leu Gly Thr Lys Glu
        275                 280                 285             
Ile Glu Glu Tyr Lys Lys Ser Val Val Ser Leu Lys Asn Glu Glu Glu
    290                 295                 300                 
Asn Glu Asn Ser Ile Ser Gln Tyr Lys Glu Ser Val Lys Arg Leu Leu
305                 310                 315                 320 
Asn Val Thr
            


<210> 2536
<211> 414
<212> PRT
<213> Homo sapiens

<400> 2536
Met Ala Ala Ser Ile Val Arg Arg Gly Met Leu Leu Ala Arg Gln Val
 1               5                  10                  15      
Val Leu Pro Gln Leu Ser Pro Ala Gly Lys Arg Tyr Leu Leu Ser Ser
            20                  25                  30          
Ala Tyr Val Asp Ser His Lys Trp Glu Ala Arg Glu Lys Glu His Tyr
        35                  40                  45              
Cys Leu Ala Asp Leu Ala Ser Leu Met Asp Lys Thr Phe Glu Arg Lys
    50                  55                  60                  
Leu Pro Val Ser Ser Leu Thr Ile Ser Arg Leu Ile Asp Asn Ile Ser
65                  70                  75                  80  
Ser Arg Glu Glu Ile Asp His Ala Glu Tyr Tyr Leu Tyr Lys Phe Arg
                85                  90                  95      
His Ser Pro Asn Cys Trp Tyr Leu Arg Asn Trp Thr Ile His Thr Trp
            100                 105                 110         
Ile Arg Gln Cys Leu Lys Tyr Asp Ala Gln Asp Lys Ala Leu Tyr Thr
        115                 120                 125             
Leu Val Asn Lys Val Gln Tyr Gly Ile Phe Pro Asp Asn Phe Thr Phe
    130                 135                 140                 
Asn Leu Leu Met Asp Ser Phe Ile Lys Lys Glu Asn Tyr Lys Asp Ala
145                 150                 155                 160 
Leu Ser Val Val Phe Glu Val Met Met Gln Glu Ala Phe Glu Val Pro
                165                 170                 175     
Ser Thr Gln Leu Leu Ser Leu Tyr Val Leu Phe His Cys Leu Ala Lys
            180                 185                 190         
Lys Thr Asp Phe Ser Trp Glu Glu Glu Arg Asn Phe Gly Ala Ser Leu
        195                 200                 205             
Leu Leu Pro Gly Leu Lys Gln Lys Asn Ser Val Gly Phe Ser Ser Gln
    210                 215                 220                 
Leu Tyr Gly Tyr Ala Leu Leu Gly Lys Val Glu Leu Gln Gln Gly Leu
225                 230                 235                 240 
Arg Ala Val Tyr His Asn Met Pro Leu Ile Trp Lys Pro Gly Tyr Leu
                245                 250                 255     
Asp Arg Ala Leu Gln Val Met Glu Lys Val Ala Ala Ser Pro Glu Asp
            260                 265                 270         
Ile Lys Leu Cys Arg Glu Ala Leu Asp Val Leu Asp Ala Val Leu Lys
        275                 280                 285             
Ala Leu Thr Ser Ala Asp Gly Ala Ser Glu Glu Gln Ser Gln Asn Asp
    290                 295                 300                 
Glu Asp Asn Gln Gly Ser Glu Lys Leu Val Glu Gln Leu Asp Ile Glu
305                 310                 315                 320 
Glu Thr Glu Gln Ser Lys Leu Pro Gln Tyr Leu Glu Arg Phe Lys Ala
                325                 330                 335     
Leu His Ser Lys Leu Gln Ala Leu Gly Lys Ile Glu Ser Glu Gly Leu
            340                 345                 350         
Leu Ser Leu Thr Thr Gln Leu Val Lys Glu Lys Leu Ser Thr Cys Glu
        355                 360                 365             
Ala Glu Asp Ile Ala Thr Tyr Glu Gln Asn Leu Gln Gln Trp His Leu
    370                 375                 380                 
Asp Leu Val Gln Leu Ile Gln Arg Glu Gln Gln Gln Arg Glu Gln Ala
385                 390                 395                 400 
Lys Gln Glu Tyr Gln Ala Gln Lys Ala Ala Lys Ala Ser Ala
                405                 410                 


<210> 2537
<211> 311
<212> PRT
<213> Homo sapiens

<400> 2537
Val Ile Val Leu Gly Leu Tyr Ile Tyr Val Thr Tyr Lys Lys Pro Asp
 1               5                  10                  15      
Val Asn Trp Gly Ser Ser Thr Gln Ala Leu Thr Tyr Leu Asn Ala Leu
            20                  25                  30          
Gln His Ser Ile Arg Leu Ser Gly Val Glu Asp His Val Lys Asn Phe
        35                  40                  45              
Arg Pro Gln Cys Leu Val Met Thr Gly Ala Pro Asn Ser Arg Pro Ala
    50                  55                  60                  
Leu Leu His Leu Val His Asp Phe Thr Lys Asn Val Gly Leu Met Ile
65                  70                  75                  80  
Cys Gly His Val His Met Gly Pro Arg Arg Gln Ala Met Lys Glu Met
                85                  90                  95      
Ser Ile Asp Gln Ala Lys Tyr Gln Arg Trp Leu Ile Lys Asn Lys Met
            100                 105                 110         
Lys Ala Phe Tyr Ala Pro Val His Ala Asp Asp Leu Arg Glu Gly Ala
        115                 120                 125             
Gln Tyr Leu Met Gln Ala Ala Gly Leu Gly Arg Met Lys Pro Asn Thr
    130                 135                 140                 
Leu Val Leu Gly Phe Lys Lys Asp Trp Leu Gln Ala Asp Met Arg Asp
145                 150                 155                 160 
Val Asp Met Tyr Ile Asn Leu Phe His Asp Ala Phe Asp Ile Gln Tyr
                165                 170                 175     
Gly Val Val Val Ile Arg Leu Lys Glu Gly Leu Asp Ile Ser His Leu
            180                 185                 190         
Gln Gly Gln Glu Glu Leu Leu Ser Ser Gln Glu Lys Ser Pro Gly Thr
        195                 200                 205             
Lys Asp Val Val Val Ser Val Glu Tyr Ser Lys Lys Ser Asp Leu Asp
    210                 215                 220                 
Thr Ser Lys Pro Leu Ser Glu Lys Pro Ile Thr His Lys Glu Ser Lys
225                 230                 235                 240 
Gly Pro Ile Val Pro Leu Asn Val Ala Asp Gln Lys Leu Leu Glu Ala
                245                 250                 255     
Ser Thr Gln Phe Gln Lys Lys Gln Gly Lys Asn Thr Ile Asp Val Trp
            260                 265                 270         
Trp Leu Phe Asp Asp Gly Gly Leu Thr Leu Leu Ile Pro Tyr Leu Leu
        275                 280                 285             
Thr Thr Lys Lys Lys Trp Lys Asp Cys Lys Ile Arg Val Phe Ile Gly
    290                 295                 300                 
Gly Lys Ile Asn Arg Ile Asp
305                 310     


<210> 2538
<211> 172
<212> PRT
<213> Homo sapiens

<400> 2538
Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Ser Pro Leu Leu Tyr Ser
 1               5                  10                  15      
Thr Lys Met Ser Thr Gln Val Ser Val Gln Leu Leu Leu Val Val Tyr
            20                  25                  30          
Ile Ala Gly Phe Leu Ile Ala Val Ser Tyr Thr Thr Ser Phe Tyr Phe
        35                  40                  45              
Leu Leu Phe Cys Gly Pro Asn Gln Val Asn His Phe Phe Cys Asp Phe
    50                  55                  60                  
Ala Pro Leu Leu Glu Leu Ser Cys Ser Asp Ile Ser Val Ser Thr Val
65                  70                  75                  80  
Val Leu Ser Phe Ser Ser Gly Ser Ile Ile Val Val Thr Val Cys Val
                85                  90                  95      
Ile Ala Val Cys Tyr Ile Tyr Ile Leu Ile Thr Ile Leu Lys Met His
            100                 105                 110         
Ser Thr Lys Gly Arg His Lys Ala Phe Ser Thr Cys Thr Ser His Leu
        115                 120                 125             
Thr Ala Val Thr Leu Phe Tyr Gly Thr Ile Thr Phe Ile Tyr Val Met
    130                 135                 140                 
Pro Lys Ser Ser Tyr Ser Thr Asp Gln Asn Lys Val Val Ser Val Phe
145                 150                 155                 160 
Tyr Thr Val Val Ile Pro Met Leu Asn Pro Leu Ile
                165                 170         


<210> 2539
<211> 285
<212> PRT
<213> Homo sapiens

<400> 2539
Ser Thr Gln Asp Glu Val Ala Ala Ser Ala Ile Leu Thr Ala Gln Leu
 1               5                  10                  15      
Asp Glu Glu Leu Gly Gly Thr Pro Val Gln Ser Arg Val Val Gln Gly
            20                  25                  30          
Lys Glu Pro Ala His Leu Met Ser Leu Phe Gly Gly Lys Pro Met Ile
        35                  40                  45              
Ile Tyr Lys Gly Gly Thr Ser Arg Glu Gly Gly Gln Thr Ala Pro Ala
    50                  55                  60                  
Ser Thr Arg Leu Phe Gln Val Arg Ala Asn Ser Ala Gly Ala Thr Arg
65                  70                  75                  80  
Ala Val Glu Val Leu Pro Lys Ala Gly Ala Leu Asn Ser Asn Asp Ala
                85                  90                  95      
Phe Val Leu Lys Thr Pro Ser Ala Ala Tyr Leu Trp Val Gly Thr Gly
            100                 105                 110         
Ala Ser Glu Ala Glu Lys Thr Gly Ala Gln Glu Leu Leu Arg Val Leu
        115                 120                 125             
Arg Ala Gln Pro Val Gln Val Ala Glu Gly Ser Glu Pro Asp Gly Phe
    130                 135                 140                 
Trp Glu Ala Leu Gly Gly Lys Ala Ala Tyr Arg Thr Ser Pro Arg Leu
145                 150                 155                 160 
Lys Asp Lys Lys Met Asp Ala His Pro Pro Arg Leu Phe Ala Cys Ser
                165                 170                 175     
Asn Lys Ile Gly Arg Phe Val Ile Glu Glu Val Pro Gly Glu Leu Met
            180                 185                 190         
Gln Glu Asp Leu Ala Thr Asp Asp Val Met Leu Leu Asp Thr Trp Asp
        195                 200                 205             
Gln Val Phe Val Trp Val Gly Lys Asp Ser Gln Glu Glu Glu Lys Thr
    210                 215                 220                 
Glu Ala Leu Thr Ser Ala Lys Arg Tyr Ile Glu Thr Asp Pro Ala Asn
225                 230                 235                 240 
Arg Asp Arg Arg Thr Pro Ile Thr Val Val Lys Gln Gly Phe Glu Pro
                245                 250                 255     
Pro Ser Phe Val Gly Trp Phe Leu Gly Trp Asp Asp Asp Tyr Trp Ser
            260                 265                 270         
Val Asp Pro Leu Asp Arg Ala Met Ala Glu Leu Ala Ala
        275                 280                 285 


<210> 2540
<211> 595
<212> PRT
<213> Homo sapiens

<400> 2540
Met Ser Ser Ser Tyr Trp Ser Glu Thr Ser Ser Ser Ser Cys Gly Thr
 1               5                  10                  15      
Gln Gln Leu Pro Glu Val Leu Gln Cys Gln Pro Gln His Tyr His Cys
            20                  25                  30          
Tyr His Gln Ser Ser Gln Ala Gln Gln Pro Pro Glu Lys Asn Val Val
        35                  40                  45              
Tyr Glu Arg Val Arg Thr Tyr Ser Gly Pro Met Asn Lys Val Val Gln
    50                  55                  60                  
Ala Leu Asp Pro Phe Asn Ser Arg Glu Val Leu Ser Pro Leu Lys Thr
65                  70                  75                  80  
Thr Ser Ser Tyr Gln Asn Leu Val Trp Ser Asp His Ser Gln Glu Leu
                85                  90                  95      
His Ser Pro Thr Leu Lys Ile Ser Thr Cys Ala Pro Ser Thr Leu His
            100                 105                 110         
Ile Thr Gln Asn Thr Glu Gln Glu Leu His Ser Pro Thr Val Lys Leu
        115                 120                 125             
Thr Thr Tyr Pro Gln Thr Thr Ile Arg Lys Tyr Val Val Gln Asn Pro
    130                 135                 140                 
Glu Gln Glu Pro Leu Ser Gln Phe Leu Arg Gly Ser His Phe Phe Pro
145                 150                 155                 160 
Gly Asn Asn Val Ile Tyr Glu Lys Thr Ile Arg Lys Val Glu Lys Leu
                165                 170                 175     
Asn Thr Asp Gln Gly Cys His Pro Gln Ala Gln Cys His His His Ile
            180                 185                 190         
Ile Gln Gln Pro Gln Val Ile His Ser Ala His Trp Gln Gln Pro Asp
        195                 200                 205             
Ser Ser Gln Gln Ile Gln Ala Ile Thr Gly Asn Asn Pro Ile Ser Thr
    210                 215                 220                 
His Ile Gly Asn Glu Leu Cys His Ser Gly Ser Ser Gln Ile Cys Glu
225                 230                 235                 240 
Gln Val Ile Ile Gln Asp Asp Gly Pro Glu Lys Leu Asp Pro Arg Tyr
                245                 250                 255     
Phe Gly Glu Leu Leu Ala Asp Leu Ser Arg Lys Asn Thr Asp Leu Tyr
            260                 265                 270         
His Cys Leu Leu Glu His Leu Gln Arg Ile Gly Gly Ser Lys Gln Asp
        275                 280                 285             
Phe Glu Ser Thr Asp Glu Ser Glu Asp Ile Glu Ser Leu Ile Pro Lys
    290                 295                 300                 
Gly Leu Ser Glu Phe Thr Lys Gln Gln Ile Arg Tyr Ile Leu Gln Met
305                 310                 315                 320 
Arg Gly Met Ser Asp Lys Ser Leu Arg Leu Val Leu Ser Thr Phe Ser
                325                 330                 335     
Asn Ile Arg Glu Glu Leu Gly His Leu Gln Asn Asp Leu Thr Ser Leu
            340                 345                 350         
Glu Asn Asp Lys Met Arg Leu Glu Lys Asp Leu Ser Phe Lys Asp Thr
        355                 360                 365             
Gln Leu Lys Glu Tyr Glu Glu Leu Leu Ala Ser Val Arg Ala Asn Asn
    370                 375                 380                 
His Gln Gln Gln Gln Gly Leu Gln Asp Ser Ser Ser Lys Cys Gln Ala
385                 390                 395                 400 
Leu Glu Glu Asn Asn Leu Ser Leu Arg His Thr Leu Ser Asp Met Glu
                405                 410                 415     
Tyr Arg Leu Lys Glu Leu Glu Tyr Cys Lys Arg Asn Leu Glu Gln Glu
            420                 425                 430         
Asn Gln Asn Leu Arg Met Gln Val Ser Glu Thr Cys Thr Gly Pro Met
        435                 440                 445             
Leu Gln Ala Lys Met Asp Glu Ile Gly Asn His Tyr Thr Glu Met Val
    450                 455                 460                 
Lys Asn Leu Arg Met Glu Lys Asp Arg Glu Ile Cys Arg Leu Arg Ser
465                 470                 475                 480 
Gln Leu Asn Gln Tyr His Lys Asp Val Ser Lys Arg Glu Gly Ser Cys
                485                 490                 495     
Ser Asp Phe Gln Phe Lys Leu His Glu Leu Thr Ser Leu Leu Glu Glu
            500                 505                 510         
Lys Asp Ser Leu Ile Lys Arg Gln Ser Glu Glu Leu Ser Lys Leu Arg
        515                 520                 525             
Gln Glu Ile Tyr Ser Ser His Asn Gln Pro Ser Thr Gly Gly Arg Thr
    530                 535                 540                 
Thr Ile Thr Thr Lys Lys Tyr Arg Thr Gln Tyr Pro Ile Leu Gly Leu
545                 550                 555                 560 
Leu Tyr Asp Asp Tyr Glu Tyr Ile Pro Pro Gly Ser Glu Thr Gln Thr
                565                 570                 575     
Ile Val Ile Glu Lys Thr Glu Asp Lys Tyr Thr Cys Val Ser Ser Leu
            580                 585                 590         
Gly His Phe
        595 


<210> 2541
<211> 1311
<212> PRT
<213> Homo sapiens

<400> 2541
Met Ser Leu Leu Gln Ser Ala Leu Asp Phe Leu Ala Gly Pro Gly Ser
 1               5                  10                  15      
Leu Gly Gly Ala Ser Gly Arg Asp Gln Ser Asp Phe Val Gly Gln Thr
            20                  25                  30          
Val Glu Leu Gly Glu Leu Arg Leu Arg Val Arg Arg Val Leu Ala Glu
        35                  40                  45              
Gly Gly Phe Ala Phe Val Tyr Glu Ala Gln Asp Val Gly Ser Gly Arg
    50                  55                  60                  
Glu Tyr Ala Leu Lys Arg Leu Leu Ser Asn Glu Glu Glu Lys Asn Arg
65                  70                  75                  80  
Ala Ile Ile Gln Glu Val Cys Phe Met Lys Lys Leu Ser Gly His Pro
                85                  90                  95      
Asn Ile Val Gln Phe Cys Ser Ala Ala Ser Ile Gly Lys Glu Glu Ser
            100                 105                 110         
Asp Thr Gly Gln Ala Glu Phe Leu Leu Leu Thr Glu Leu Cys Lys Gly
        115                 120                 125             
Gln Leu Val Glu Phe Leu Lys Lys Met Glu Ser Arg Gly Pro Leu Ser
    130                 135                 140                 
Cys Asp Thr Val Leu Lys Ile Phe Tyr Gln Thr Cys Arg Ala Val Gln
145                 150                 155                 160 
His Met His Arg Gln Lys Pro Pro Ile Ile His Arg Asp Leu Lys Val
                165                 170                 175     
Glu Asn Leu Leu Leu Ser Asn Gln Gly Thr Ile Lys Leu Cys Asp Phe
            180                 185                 190         
Gly Ser Ala Thr Thr Ile Ser His Tyr Pro Asp Tyr Ser Trp Ser Ala
        195                 200                 205             
Gln Arg Arg Ala Leu Val Glu Glu Glu Ile Thr Arg Asn Thr Thr Pro
    210                 215                 220                 
Met Tyr Arg Thr Pro Glu Ile Ile Asp Leu Tyr Ser Asn Phe Pro Ile
225                 230                 235                 240 
Gly Glu Lys Gln Asp Ile Trp Ala Leu Gly Cys Ile Leu Tyr Leu Leu
                245                 250                 255     
Cys Phe Arg Gln His Pro Phe Glu Asp Gly Ala Lys Leu Arg Ile Val
            260                 265                 270         
Asn Gly Lys Tyr Ser Ile Pro Pro His Asp Thr Gln Tyr Thr Val Phe
        275                 280                 285             
His Ser Leu Ile Arg Ala Met Leu Gln Val Asn Pro Glu Glu Arg Leu
    290                 295                 300                 
Ser Ile Ala Glu Val Val His Gln Leu Gln Glu Ile Ala Ala Ala Arg
305                 310                 315                 320 
Asn Val Asn Pro Lys Ser Pro Ile Thr Glu Leu Leu Glu Gln Asn Gly
                325                 330                 335     
Gly Tyr Gly Ser Ala Thr Leu Ser Arg Gly Pro Pro Pro Pro Val Gly
            340                 345                 350         
Pro Ala Gly Ser Gly Tyr Ser Gly Gly Leu Ala Leu Ala Glu Tyr Asp
        355                 360                 365             
Gln Pro Tyr Gly Gly Phe Leu Asp Ile Leu Arg Gly Gly Thr Glu Arg
    370                 375                 380                 
Leu Phe Thr Asn Leu Lys Asp Thr Ser Ser Lys Val Ile Gln Ser Val
385                 390                 395                 400 
Ala Asn Tyr Ala Lys Gly Asp Leu Asp Ile Ser Tyr Ile Thr Ser Arg
                405                 410                 415     
Ile Ala Val Met Ser Phe Pro Ala Glu Gly Val Glu Ser Ala Leu Lys
            420                 425                 430         
Asn Asn Ile Glu Asp Val Arg Leu Phe Leu Asp Ser Lys His Pro Gly
        435                 440                 445             
His Tyr Ala Val Tyr Asn Leu Ser Pro Arg Thr Tyr Arg Pro Ser Arg
    450                 455                 460                 
Phe His Asn Arg Val Ser Glu Cys Gly Trp Ala Ala Arg Arg Ala Pro
465                 470                 475                 480 
His Leu His Thr Leu Tyr Asn Ile Cys Arg Asn Met His Ala Trp Leu
                485                 490                 495     
Arg Gln Asp His Lys Asn Val Cys Val Val His Cys Met Asp Gly Arg
            500                 505                 510         
Ala Ala Ser Ala Val Ala Val Cys Ser Phe Leu Cys Phe Cys Arg Leu
        515                 520                 525             
Phe Ser Thr Ala Glu Ala Ala Val Tyr Met Phe Ser Met Lys Arg Cys
    530                 535                 540                 
Pro Pro Gly Ile Trp Pro Ser His Lys Arg Tyr Ile Glu Tyr Met Cys
545                 550                 555                 560 
Asp Met Val Ala Glu Glu Pro Ile Thr Pro His Ser Lys Pro Ile Leu
                565                 570                 575     
Val Arg Ala Val Val Met Thr Pro Val Pro Leu Phe Ser Lys Gln Arg
            580                 585                 590         
Ser Gly Cys Arg Pro Phe Cys Glu Val Tyr Val Gly Asp Glu Arg Val
        595                 600                 605             
Ala Ser Thr Ser Gln Glu Tyr Asp Lys Met Arg Asp Phe Lys Ile Glu
    610                 615                 620                 
Asp Gly Lys Ala Val Ile Pro Leu Gly Val Thr Val Gln Gly Asp Val
625                 630                 635                 640 
Leu Ile Val Ile Tyr His Ala Arg Ser Thr Leu Gly Gly Arg Leu Gln
                645                 650                 655     
Ala Lys Met Ala Ser Met Lys Met Phe Gln Ile Gln Phe His Thr Gly
            660                 665                 670         
Phe Val Pro Arg Asn Ala Thr Thr Val Lys Phe Ala Lys Tyr Asp Leu
        675                 680                 685             
Asp Ala Cys Asp Ile Gln Glu Lys Tyr Pro Asp Leu Phe Gln Val Asn
    690                 695                 700                 
Leu Glu Val Glu Val Glu Pro Arg Asp Arg Pro Ser Arg Glu Ala Pro
705                 710                 715                 720 
Pro Trp Glu Asn Ser Ser Met Arg Gly Leu Asn Pro Lys Ile Leu Phe
                725                 730                 735     
Ser Ser Arg Glu Glu Gln Gln Asp Ile Leu Ser Lys Phe Gly Lys Pro
            740                 745                 750         
Glu Leu Pro Arg Gln Pro Gly Ser Thr Ala Gln Tyr Asp Ala Gly Ala
        755                 760                 765             
Gly Ser Pro Glu Ala Glu Pro Thr Asp Ser Asp Ser Pro Pro Ser Ser
    770                 775                 780                 
Ser Ala Asp Ala Ser Arg Phe Leu His Thr Leu Asp Trp Gln Glu Glu
785                 790                 795                 800 
Lys Glu Ala Glu Thr Gly Ala Glu Asn Ala Ser Ser Lys Glu Ser Glu
                805                 810                 815     
Ser Ala Leu Met Glu Asp Arg Asp Glu Ser Glu Val Ser Asp Glu Gly
            820                 825                 830         
Gly Ser Pro Ile Ser Ser Glu Gly Gln Glu Pro Arg Ala Asp Pro Glu
        835                 840                 845             
Pro Pro Gly Leu Ala Ala Gly Leu Val Gln Gln Asp Leu Val Phe Glu
    850                 855                 860                 
Val Glu Thr Pro Ala Val Leu Pro Glu Pro Val Pro Gln Glu Asp Gly
865                 870                 875                 880 
Val Asp Leu Leu Gly Leu His Ser Glu Val Gly Ala Gly Pro Ala Val
                885                 890                 895     
Pro Pro Gln Ala Cys Lys Ala Pro Ser Ser Asn Thr Asp Leu Leu Ser
            900                 905                 910         
Cys Leu Leu Gly Pro Pro Glu Ala Ala Ser Gln Gly Pro Pro Glu Asp
        915                 920                 925             
Leu Leu Ser Glu Asp Pro Leu Leu Leu Ala Ser Pro Ala Pro Pro Leu
    930                 935                 940                 
Ser Val Gln Ser Thr Pro Arg Gly Gly Pro Pro Ala Ala Ala Asp Pro
945                 950                 955                 960 
Phe Gly Pro Leu Leu Pro Ser Ser Gly Asn Asn Ser Gln Pro Cys Ser
                965                 970                 975     
Asn Pro Asp Leu Phe Gly Glu Phe Leu Asn Ser Asp Ser Val Thr Val
            980                 985                 990         
Pro Pro Ser Phe Pro Ser Ala His Ser Ala Pro Pro Pro Ser Cys Ser
        995                 1000                1005            
Ala Asp Phe Leu His Leu Gly Asp Leu Pro Gly Glu Pro Ser Lys Met
    1010                1015                1020                
Thr Ala Ser Ser Ser Asn Pro Asp Leu Leu Gly Gly Trp Ala Ala Trp
1025                1030                1035                1040
Thr Glu Thr Ala Ala Ser Ala Val Ala Pro Thr Pro Ala Thr Glu Gly
                1045                1050                1055    
Pro Leu Phe Ser Pro Gly Gly Gln Pro Ala Pro Cys Gly Ser Gln Ala
            1060                1065                1070        
Ser Trp Thr Lys Ser Gln Asn Pro Asp Pro Phe Ala Asp Leu Gly Asp
        1075                1080                1085            
Leu Ser Ser Gly Leu Gln Gly Ser Pro Ala Gly Phe Pro Pro Gly Gly
    1090                1095                1100                
Phe Ile Pro Lys Thr Ala Thr Thr Pro Lys Gly Ser Ser Ser Trp Gln
1105                1110                1115                1120
Thr Ser Arg Pro Pro Ala Gln Gly Ala Ser Trp Pro Pro Gln Ala Lys
                1125                1130                1135    
Pro Pro Pro Lys Ala Cys Thr Gln Pro Arg Pro Asn Tyr Ala Ser Asn
            1140                1145                1150        
Phe Ser Val Ile Gly Ala Arg Glu Glu Arg Gly Val Arg Ala Pro Ser
        1155                1160                1165            
Phe Ala Gln Lys Pro Lys Val Ser Glu Asn Asp Phe Glu Asp Leu Leu
    1170                1175                1180                
Ser Asn Gln Gly Phe Ser Ser Arg Ser Asp Lys Lys Gly Pro Lys Thr
1185                1190                1195                1200
Ile Ala Glu Met Arg Lys Gln Asp Leu Ala Lys Asp Thr Asp Pro Leu
                1205                1210                1215    
Lys Leu Lys Leu Leu Asp Trp Ile Glu Gly Lys Glu Arg Asn Ile Arg
            1220                1225                1230        
Ala Leu Leu Ser Thr Leu His Thr Val Leu Trp Asp Gly Glu Ser Arg
        1235                1240                1245            
Trp Thr Pro Val Gly Met Ala Asp Leu Val Ala Pro Glu Gln Val Lys
    1250                1255                1260                
Lys His Tyr Arg Arg Ala Val Leu Ala Val His Pro Asp Lys Ala Ala
1265                1270                1275                1280
Gly Gln Pro Tyr Glu Gln His Ala Lys Met Ile Phe Met Glu Leu Asn
                1285                1290                1295    
Asp Ala Trp Ser Glu Phe Glu Asn Gln Gly Ser Arg Pro Leu Phe
            1300                1305                1310    


<210> 2542
<211> 785
<212> PRT
<213> Homo sapiens

<400> 2542
Met Gly Lys Lys Tyr Lys Asn Ile Val Leu Leu Lys Gly Leu Glu Val
 1               5                  10                  15      
Ile Asn Asp Tyr His Phe Arg Met Val Lys Ser Leu Leu Ser Asn Asp
            20                  25                  30          
Leu Lys Leu Asn Leu Lys Met Arg Glu Glu Tyr Asp Lys Ile Gln Ile
        35                  40                  45              
Ala Asp Leu Met Glu Glu Lys Phe Arg Gly Asp Ala Gly Leu Gly Lys
    50                  55                  60                  
Leu Ile Lys Ile Phe Glu Asp Ile Pro Thr Leu Glu Asp Leu Ala Glu
65                  70                  75                  80  
Thr Leu Lys Lys Glu Lys Leu Lys Val Lys Gly Pro Ala Leu Ser Arg
                85                  90                  95      
Lys Arg Lys Lys Glu Val His Ala Thr Ser Pro Ala Pro Ser Thr Ser
            100                 105                 110         
Ser Thr Val Lys Thr Glu Gly Ala Glu Ala Thr Pro Gly Ala Gln Lys
        115                 120                 125             
Arg Lys Lys Ser Thr Lys Glu Lys Ala Gly Pro Lys Gly Ser Lys Val
    130                 135                 140                 
Ser Glu Glu Gln Thr Gln Pro Pro Ser Pro Ala Gly Ala Gly Met Ser
145                 150                 155                 160 
Thr Ala Met Gly Arg Ser Pro Ser Pro Lys Thr Ser Leu Ser Ala Pro
                165                 170                 175     
Pro Asn Ser Ser Ser Thr Glu Asn Pro Lys Thr Val Ala Lys Cys Gln
            180                 185                 190         
Val Thr Pro Arg Arg Asn Val Leu Gln Lys Arg Pro Val Ile Val Lys
        195                 200                 205             
Val Leu Ser Thr Thr Lys Pro Phe Glu Tyr Glu Thr Pro Glu Met Glu
    210                 215                 220                 
Lys Lys Ile Met Phe His Ala Thr Val Ala Thr Gln Thr Gln Phe Phe
225                 230                 235                 240 
His Val Lys Val Leu Asn Thr Ser Leu Lys Glu Lys Phe Asn Gly Lys
                245                 250                 255     
Lys Ile Ile Ile Ile Ser Asp Tyr Leu Glu Tyr Asp Ser Leu Leu Glu
            260                 265                 270         
Val Asn Glu Glu Ser Thr Val Ser Glu Ala Gly Pro Asn Gln Thr Phe
        275                 280                 285             
Glu Val Pro Asn Lys Ile Ile Asn Arg Ala Lys Glu Thr Leu Lys Ile
    290                 295                 300                 
Asp Ile Leu His Lys Gln Ala Ser Gly Asn Ile Val Tyr Gly Val Phe
305                 310                 315                 320 
Met Leu His Lys Lys Thr Val Asn Gln Lys Thr Thr Ile Tyr Glu Ile
                325                 330                 335     
Gln Asp Asp Arg Gly Lys Met Asp Val Val Gly Thr Gly Gln Cys His
            340                 345                 350         
Asn Ile Pro Cys Glu Glu Gly Asp Lys Leu Gln Leu Phe Cys Phe Arg
        355                 360                 365             
Leu Arg Lys Lys Asn Gln Met Ser Lys Leu Ile Ser Glu Met His Ser
    370                 375                 380                 
Phe Ile Gln Ile Lys Lys Lys Thr Asn Pro Arg Asn Asn Asp Pro Lys
385                 390                 395                 400 
Ser Met Lys Leu Pro Gln Glu Gln Arg Gln Leu Pro Tyr Pro Ser Glu
                405                 410                 415     
Ala Ser Thr Thr Phe Pro Glu Ser His Leu Arg Thr Pro Gln Met Pro
            420                 425                 430         
Pro Thr Thr Pro Ser Ser Ser Phe Phe Thr Lys Lys Ser Glu Asp Thr
        435                 440                 445             
Ile Ser Lys Met Asn Asp Phe Met Arg Met Gln Ile Leu Lys Glu Gly
    450                 455                 460                 
Ser His Phe Pro Gly Pro Phe Met Thr Ser Ile Gly Pro Ala Glu Ser
465                 470                 475                 480 
His Pro His Thr Pro Gln Met Pro Pro Ser Thr Pro Ser Ser Ser Phe
                485                 490                 495     
Leu Thr Thr Lys Ser Glu Asp Thr Ile Ser Lys Met Asn Asp Phe Met
            500                 505                 510         
Arg Met Gln Ile Leu Lys Glu Gly Ser His Phe Pro Gly Pro Phe Met
        515                 520                 525             
Thr Ser Ile Gly Pro Ala Glu Ser His Pro His Thr Pro Gln Met Pro
    530                 535                 540                 
Pro Ser Thr Pro Ser Ser Ser Phe Leu Thr Thr Leu Lys Pro Arg Leu
545                 550                 555                 560 
Lys Thr Glu Pro Glu Glu Val Ser Ile Glu Asp Ser Ala Gln Ser Asp
                565                 570                 575     
Leu Lys Glu Val Met Val Leu Asn Ala Thr Glu Ser Phe Val Tyr Glu
            580                 585                 590         
Pro Lys Glu Gln Lys Lys Met Phe His Ala Thr Val Ala Thr Glu Asn
        595                 600                 605             
Glu Val Phe Arg Val Lys Val Phe Asn Ile Asp Leu Lys Glu Lys Phe
    610                 615                 620                 
Thr Pro Lys Lys Ile Ile Ala Ile Ala Asn Tyr Val Cys Arg Asn Gly
625                 630                 635                 640 
Phe Leu Glu Val Tyr Pro Phe Thr Leu Val Ala Asp Val Asn Ala Asp
                645                 650                 655     
Arg Asn Met Glu Ile Pro Lys Gly Leu Ile Arg Ser Ala Ser Val Thr
            660                 665                 670         
Pro Lys Ile Asn Gln Leu Cys Ser Gln Thr Lys Gly Ser Phe Val Asn
        675                 680                 685             
Gly Val Phe Glu Val His Lys Lys Asn Val Arg Gly Glu Phe Thr Tyr
    690                 695                 700                 
Tyr Glu Ile Gln Asp Asn Thr Gly Lys Met Glu Val Val Val His Gly
705                 710                 715                 720 
Arg Leu Asn Thr Ile Asn Cys Glu Glu Gly Asp Lys Leu Lys Leu Thr
                725                 730                 735     
Ser Phe Glu Leu Ala Pro Lys Ser Gly Asn Thr Gly Glu Leu Arg Ser
            740                 745                 750         
Val Ile His Ser His Ile Lys Val Ile Lys Thr Arg Lys Asn Lys Lys
        755                 760                 765             
Asp Ile Leu Asn Pro Asp Ser Ser Met Glu Thr Ser Pro Asp Phe Phe
    770                 775                 780                 
Phe
785 


<210> 2543
<211> 547
<212> PRT
<213> Homo sapiens

<400> 2543
Met Tyr Arg Leu Leu Ser Ala Val Thr Ala Arg Ala Ala Ala Pro Arg
 1               5                  10                  15      
Gly Leu Ala Ser Ser Cys Gly Arg Cys Gly Val His Gln Arg Ala Gly
            20                  25                  30          
Leu Pro Pro Leu Gly His Gly Trp Val Gly Gly Leu Gly Leu Gly Leu
        35                  40                  45              
Gly Leu Ala Leu Gly Val Lys Leu Ala Gly Gly Leu Arg Gly Ala Ala
    50                  55                  60                  
Pro Ala Gln Ser Pro Ala Ala Pro Asp Pro Glu Ala Ser Pro Leu Ala
65                  70                  75                  80  
Glu Pro Pro Gln Glu Gln Ser Leu Ala Pro Trp Ser Pro Gln Thr Pro
                85                  90                  95      
Ala Pro Pro Cys Ser Arg Cys Phe Ala Arg Ala Ile Glu Ser Ser Arg
            100                 105                 110         
Asp Leu Leu His Arg Ile Lys Asp Glu Val Gly Ala Pro Gly Ile Val
        115                 120                 125             
Val Gly Val Ser Val Asp Gly Lys Glu Val Trp Ser Glu Gly Leu Gly
    130                 135                 140                 
Tyr Ala Asp Val Glu Asn Arg Val Pro Cys Lys Pro Glu Thr Val Met
145                 150                 155                 160 
Arg Ile Ala Ser Ile Ser Lys Ser Leu Thr Met Val Ala Leu Ala Lys
                165                 170                 175     
Leu Trp Glu Ala Gly Lys Leu Asp Leu Asp Ile Pro Val Gln His Tyr
            180                 185                 190         
Val Pro Glu Phe Pro Glu Lys Glu Tyr Glu Gly Glu Lys Val Ser Val
        195                 200                 205             
Thr Thr Arg Leu Leu Ile Ser His Leu Ser Gly Ile Arg His Tyr Glu
    210                 215                 220                 
Lys Asp Ile Lys Lys Val Lys Glu Glu Lys Ala Tyr Lys Ala Leu Lys
225                 230                 235                 240 
Met Met Lys Glu Asn Val Ala Phe Glu Gln Glu Lys Glu Gly Lys Ser
                245                 250                 255     
Asn Glu Lys Asn Asp Phe Thr Lys Phe Lys Thr Glu Gln Glu Asn Glu
            260                 265                 270         
Ala Lys Cys Arg Asn Ser Lys Pro Gly Lys Lys Lys Asn Asp Phe Glu
        275                 280                 285             
Gln Gly Glu Leu Tyr Leu Arg Glu Lys Phe Glu Asn Ser Ile Glu Ser
    290                 295                 300                 
Leu Arg Leu Phe Lys Asn Asp Pro Leu Phe Phe Lys Pro Gly Ser Gln
305                 310                 315                 320 
Phe Leu Tyr Ser Thr Phe Gly Tyr Thr Leu Leu Ala Ala Ile Val Glu
                325                 330                 335     
Arg Ala Ser Gly Cys Lys Tyr Leu Asp Tyr Met Gln Lys Ile Phe His
            340                 345                 350         
Asp Leu Asp Met Leu Thr Thr Val Gln Glu Glu Asn Glu Pro Val Ile
        355                 360                 365             
Tyr Asn Arg Ala Arg Phe Tyr Val Tyr Asn Lys Lys Lys Arg Leu Val
    370                 375                 380                 
Asn Thr Pro Tyr Val Asp Asn Ser Tyr Lys Trp Ala Gly Gly Gly Phe
385                 390                 395                 400 
Leu Ser Thr Val Gly Asp Leu Leu Lys Phe Gly Asn Ala Met Leu Tyr
                405                 410                 415     
Gly Tyr Gln Val Gly Leu Phe Lys Asn Ser Asn Glu Asn Leu Leu Pro
            420                 425                 430         
Gly Tyr Leu Lys Pro Glu Thr Met Val Met Met Trp Thr Pro Val Pro
        435                 440                 445             
Asn Thr Glu Met Ser Trp Asp Lys Glu Gly Lys Tyr Ala Met Ala Trp
    450                 455                 460                 
Gly Val Val Glu Lys Lys Gln Thr Tyr Gly Ser Cys Arg Lys Gln Arg
465                 470                 475                 480 
His Tyr Ala Ser His Thr Gly Gly Ala Val Gly Ala Ser Ser Val Leu
                485                 490                 495     
Leu Val Leu Pro Glu Glu Leu Asp Thr Glu Thr Ile Asn Asn Lys Val
            500                 505                 510         
Pro Pro Arg Gly Ile Ile Val Ser Ile Ile Cys Asn Met Gln Ser Val
        515                 520                 525             
Gly Leu Asn Ser Thr Ala Leu Lys Ile Ala Leu Glu Phe Asp Lys Asp
    530                 535                 540                 
Arg Ser Asp
545         


<210> 2544
<211> 653
<212> PRT
<213> Homo sapiens

<400> 2544
Met Pro Val Gly Gly Leu Leu Pro Leu Phe Ser Ser Pro Ala Gly Gly
 1               5                  10                  15      
Val Leu Gly Gly Gly Leu Gly Gly Gly Gly Gly Arg Lys Gly Ser Gly
            20                  25                  30          
Pro Ala Ala Leu Arg Leu Thr Glu Lys Phe Val Leu Leu Leu Val Phe
        35                  40                  45              
Ser Ala Phe Ile Thr Leu Cys Phe Gly Ala Ile Phe Phe Leu Pro Asp
    50                  55                  60                  
Ser Ser Lys Leu Leu Ser Gly Val Leu Phe His Ser Ser Pro Ala Leu
65                  70                  75                  80  
Gln Pro Ala Ala Asp His Lys Pro Gly Pro Gly Ala Arg Ala Glu Asp
                85                  90                  95      
Ala Ala Glu Gly Arg Ala Arg Arg Arg Glu Glu Gly Ala Pro Gly Asp
            100                 105                 110         
Pro Glu Ala Ala Leu Glu Asp Asn Leu Ala Arg Ile Arg Glu Asn His
        115                 120                 125             
Glu Arg Ala Leu Arg Glu Ala Lys Glu Thr Leu Gln Lys Leu Pro Glu
    130                 135                 140                 
Glu Ile Gln Arg Asp Ile Leu Leu Glu Lys Lys Lys Val Ala Gln Asp
145                 150                 155                 160 
Gln Leu Arg Asp Lys Ala Pro Phe Arg Gly Leu Pro Pro Val Asp Phe
                165                 170                 175     
Val Pro Pro Ile Gly Val Glu Ser Arg Glu Pro Ala Asp Ala Ala Ile
            180                 185                 190         
Arg Glu Lys Arg Ala Lys Ile Lys Glu Met Met Lys His Ala Trp Asn
        195                 200                 205             
Asn Tyr Lys Gly Tyr Ala Trp Gly Leu Asn Glu Leu Lys Pro Ile Ser
    210                 215                 220                 
Lys Gly Gly His Ser Ser Ser Leu Phe Gly Asn Ile Lys Gly Ala Thr
225                 230                 235                 240 
Ile Val Asp Ala Leu Asp Thr Leu Phe Ile Met Glu Met Lys His Glu
                245                 250                 255     
Phe Glu Glu Ala Lys Ser Trp Val Glu Glu Asn Leu Asp Phe Asn Val
            260                 265                 270         
Asn Ala Glu Ile Ser Val Phe Glu Val Asn Ile Arg Phe Val Gly Gly
        275                 280                 285             
Leu Leu Ser Ala Tyr Tyr Leu Ser Gly Glu Glu Ile Phe Arg Lys Lys
    290                 295                 300                 
Ala Val Glu Leu Gly Val Lys Leu Leu Pro Ala Phe His Thr Pro Ser
305                 310                 315                 320 
Gly Ile Pro Trp Ala Leu Leu Asn Met Lys Ser Gly Ile Gly Arg Asn
                325                 330                 335     
Trp Pro Trp Ala Ser Gly Gly Ser Ser Ile Leu Ala Glu Phe Gly Thr
            340                 345                 350         
Leu His Leu Glu Phe Met His Leu Ser His Leu Ser Gly Asn Pro Ile
        355                 360                 365             
Phe Ala Glu Lys Val Met Asn Ile Arg Thr Val Leu Asn Lys Leu Glu
    370                 375                 380                 
Lys Pro Gln Gly Leu Tyr Pro Asn Tyr Leu Asn Pro Ser Ser Gly Gln
385                 390                 395                 400 
Trp Gly Gln His His Val Ser Val Gly Gly Leu Gly Asp Ser Phe Tyr
                405                 410                 415     
Glu Tyr Leu Leu Lys Ala Trp Leu Met Ser Asp Lys Thr Asp Leu Glu
            420                 425                 430         
Ala Lys Lys Met Tyr Phe Asp Ala Val Gln Ala Ile Glu Thr His Leu
        435                 440                 445             
Ile Arg Lys Ser Ser Ser Gly Leu Thr Tyr Ile Ala Glu Trp Lys Arg
    450                 455                 460                 
Gly Leu Leu Glu His Lys Met Gly His Leu Thr Cys Phe Ala Gly Gly
465                 470                 475                 480 
Met Phe Ala Leu Gly Ala Asp Ala Ala Pro Glu Gly Met Ala Gln His
                485                 490                 495     
Tyr Leu Glu Leu Gly Ala Glu Ile Ala Arg Thr Cys His Glu Ser Tyr
            500                 505                 510         
Asn Arg Thr Phe Met Lys Leu Gly Pro Glu Ala Phe Arg Phe Asp Gly
        515                 520                 525             
Gly Val Glu Ala Ile Ala Thr Arg Gln Asn Glu Lys Tyr Tyr Ile Leu
    530                 535                 540                 
Arg Pro Glu Val Met Glu Thr Tyr Met Tyr Met Trp Arg Leu Thr His
545                 550                 555                 560 
Asp Pro Lys Tyr Arg Lys Trp Ala Trp Glu Ala Val Glu Ala Leu Glu
                565                 570                 575     
Asn His Cys Arg Val Asn Gly Gly Tyr Ser Gly Leu Arg Asp Val Tyr
            580                 585                 590         
Leu Leu His Glu Ser Tyr Asp Asp Val Gln Gln Ser Phe Phe Leu Ala
        595                 600                 605             
Glu Thr Leu Lys Tyr Leu Tyr Leu Ile Phe Ser Asp Asp Asp Leu Leu
    610                 615                 620                 
Pro Leu Glu His Trp Ile Phe Asn Ser Glu Ala His Leu Leu Pro Ile
625                 630                 635                 640 
Leu Pro Lys Asp Lys Lys Glu Val Glu Ile Arg Glu Glu
                645                 650             


<210> 2545
<211> 120
<212> PRT
<213> Homo sapiens

<400> 2545
Leu Val Arg Leu Pro Asp Ser Gly Gly Gly Arg Arg Ser Leu Val Ser
 1               5                  10                  15      
Gln Val Ala Val His Gly Glu Asn Gly Arg Gly Gly Leu Gly Cys Val
            20                  25                  30          
Arg Ala Ile Gln Cys Leu Val Pro Ser Tyr Pro Ser Pro Arg Pro Arg
        35                  40                  45              
Ser Ser Met Phe Thr Arg Ala Gln Val Arg Arg Ile Leu Gln Arg Val
    50                  55                  60                  
Pro Gly Lys Gln Arg Phe Gly Ile Tyr Arg Phe Leu Pro Phe Phe Phe
65                  70                  75                  80  
Val Leu Gly Gly Thr Met Glu Trp Ile Met Ile Lys Val Arg Val Gly
                85                  90                  95      
Gln Glu Thr Phe Tyr Asp Val Tyr Arg Arg Lys Ala Ser Glu Arg Gln
            100                 105                 110         
Tyr Gln Arg Arg Leu Glu Asp Glu
        115                 120 


<210> 2546
<211> 297
<212> PRT
<213> Homo sapiens

<400> 2546
Met Val His Gln Val Leu Tyr Arg Ala Leu Val Ser Thr Lys Trp Leu
 1               5                  10                  15      
Ala Glu Ser Ile Arg Thr Gly Lys Leu Gly Pro Gly Leu Arg Val Leu
            20                  25                  30          
Asp Ala Ser Trp Tyr Ser Pro Gly Thr Arg Glu Ala Arg Lys Glu Tyr
        35                  40                  45              
Leu Glu Arg His Val Pro Gly Ala Ser Phe Phe Asp Ile Glu Glu Cys
    50                  55                  60                  
Arg Asp Thr Ala Ser Pro Tyr Glu Met Met Leu Pro Ser Glu Ala Gly
65                  70                  75                  80  
Phe Ala Glu Tyr Val Gly Arg Leu Gly Ile Ser Asn His Thr His Val
                85                  90                  95      
Val Val Tyr Asp Gly Glu His Leu Gly Ser Phe Tyr Ala Pro Arg Val
            100                 105                 110         
Trp Trp Met Phe Arg Val Phe Gly His Arg Thr Val Ser Val Leu Asn
        115                 120                 125             
Gly Gly Phe Arg Asn Trp Leu Lys Glu Gly His Pro Val Thr Ser Glu
    130                 135                 140                 
Pro Ser Arg Pro Glu Pro Ala Val Phe Lys Ala Thr Leu Asp Arg Ser
145                 150                 155                 160 
Leu Leu Lys Thr Tyr Glu Gln Val Leu Glu Asn Leu Glu Ser Lys Arg
                165                 170                 175     
Phe Gln Leu Val Asp Ser Arg Ser Gln Gly Arg Phe Leu Gly Thr Glu
            180                 185                 190         
Pro Glu Pro Asp Ala Val Gly Leu Asp Ser Gly His Ile Arg Gly Ala
        195                 200                 205             
Val Asn Met Pro Phe Met Asp Phe Leu Thr Glu Asp Gly Phe Glu Lys
    210                 215                 220                 
Gly Pro Glu Glu Leu Arg Ala Leu Phe Gln Thr Lys Lys Val Asp Leu
225                 230                 235                 240 
Ser Gln Pro Leu Ile Ala Thr Cys Arg Lys Gly Val Thr Ala Cys His
                245                 250                 255     
Val Ala Leu Ala Ala Tyr Leu Cys Gly Lys Pro Asp Val Ala Val Tyr
            260                 265                 270         
Asp Gly Ser Trp Ser Glu Trp Phe Arg Arg Ala Pro Pro Glu Ser Arg
        275                 280                 285             
Val Ser Gln Gly Lys Ser Glu Lys Ala
    290                 295         


<210> 2547
<211> 264
<212> PRT
<213> Homo sapiens

<400> 2547
Met Ala Val Gly Ala Ser Ile Ala Ala Arg Leu Gly Thr Tyr Pro Asp
 1               5                  10                  15      
Trp Phe Phe Phe Cys Ser Phe Ile Gly Met Phe Val Phe Tyr Cys Ala
            20                  25                  30          
His Trp Gln Thr Tyr Val Ser Gly Met Leu Arg Phe Gly Lys Val Asp
        35                  40                  45              
Val Thr Glu Ile Gln Ile Ala Leu Val Ile Val Phe Val Leu Ser Ala
    50                  55                  60                  
Phe Gly Gly Ala Thr Met Trp Asp Tyr Thr Ile Pro Ile Leu Glu Ile
65                  70                  75                  80  
Lys Leu Lys Ile Leu Pro Val Leu Gly Phe Leu Gly Gly Val Ile Phe
                85                  90                  95      
Ser Cys Ser Asn Tyr Phe His Val Ile Leu His Gly Gly Val Gly Lys
            100                 105                 110         
Asn Gly Ser Thr Ile Ala Gly Thr Ser Val Leu Ser Pro Gly Leu His
        115                 120                 125             
Ile Gly Leu Ile Ile Ile Leu Ala Ile Met Ile Tyr Lys Lys Ser Ala
    130                 135                 140                 
Thr Asp Val Phe Glu Lys His Pro Cys Leu Tyr Ile Leu Met Phe Gly
145                 150                 155                 160 
Cys Val Phe Ala Lys Val Ser Gln Lys Leu Val Val Ala His Met Thr
                165                 170                 175     
Lys Ser Glu Leu Tyr Leu Gln Asp Thr Val Phe Leu Gly Pro Gly Leu
            180                 185                 190         
Leu Phe Leu Asp Gln Tyr Phe Asn Asn Phe Ile Asp Glu Tyr Val Val
        195                 200                 205             
Leu Trp Met Ala Met Val Ile Ser Ser Phe Asp Met Val Ile Tyr Phe
    210                 215                 220                 
Ser Ala Leu Cys Leu Gln Ile Ser Arg His Leu His Leu Asn Ile Phe
225                 230                 235                 240 
Lys Thr Ala Cys His Gln Ala Pro Glu Gln Val Gln Val Leu Ser Ser
                245                 250                 255     
Lys Ser His Gln Asn Asn Met Asp
            260                 


<210> 2548
<211> 1193
<212> PRT
<213> Homo sapiens

<400> 2548
Met Pro Gln Leu Leu Arg Asn Val Leu Cys Val Ile Glu Thr Phe His
 1               5                  10                  15      
Lys Tyr Ala Ser Glu Asp Ser Asn Gly Ala Thr Leu Thr Gly Arg Glu
            20                  25                  30          
Leu Lys Gln Leu Ile Gln Gly Glu Phe Gly Asp Phe Phe Gln Pro Cys
        35                  40                  45              
Val Leu His Ala Val Glu Lys Asn Ser Asn Leu Leu Asn Ile Asp Ser
    50                  55                  60                  
Asn Gly Ile Ile Ser Phe Asp Glu Phe Val Leu Ala Ile Phe Asn Leu
65                  70                  75                  80  
Leu Asn Leu Cys Tyr Leu Asp Ile Lys Ser Leu Leu Ser Ser Glu Leu
                85                  90                  95      
Arg Gln Val Thr Lys Pro Glu Lys Glu Lys Leu Asp Asp Val Asp Val
            100                 105                 110         
Gln Ala Thr Thr Gly Asp Gly Gln Trp Thr Val Gly Thr Ser Pro Thr
        115                 120                 125             
Gln Glu Lys Arg Met Leu Pro Ser Gly Met Ala Ser Ser Ser Gln Leu
    130                 135                 140                 
Ile Pro Glu Glu Ser Gly Ala Val Gly Asn Asn Arg Val Asp Pro Trp
145                 150                 155                 160 
Arg Glu Ala Lys Thr His Asn Phe Pro Gly Glu Ala Ser Glu His Asn
                165                 170                 175     
Asp Pro Lys Asn Lys His Leu Glu Gly Asp Glu Gln Ser Gln Glu Val
            180                 185                 190         
Ala Gln Asp Ile Gln Thr Thr Glu Asp Asn Glu Gly Gln Leu Lys Thr
        195                 200                 205             
Asn Lys Pro Met Ala Gly Ser Lys Lys Thr Ser Ser Pro Thr Glu Arg
    210                 215                 220                 
Lys Gly Gln Asp Lys Glu Ile Ser Gln Glu Gly Asp Glu Pro Ala Arg
225                 230                 235                 240 
Glu Gln Ser Val Ser Lys Ile Arg Asp Gln Phe Gly Glu Gln Glu Gly
                245                 250                 255     
Asn Leu Ala Thr Gln Ser Ser Pro Pro Lys Glu Ala Thr Gln Arg Pro
            260                 265                 270         
Cys Glu Asp Gln Glu Val Arg Thr Glu Lys Glu Lys His Ser Asn Ile
        275                 280                 285             
Gln Glu Pro Pro Leu Gln Arg Glu Asp Glu Pro Ser Ser Gln His Ala
    290                 295                 300                 
Asp Leu Pro Glu Gln Ala Ala Ala Arg Ser Pro Ser Gln Thr Gln Lys
305                 310                 315                 320 
Ser Thr Asp Ser Lys Asp Val Cys Arg Met Phe Asp Thr Gln Glu Pro
                325                 330                 335     
Gly Lys Asp Ala Asp Gln Thr Pro Ala Lys Thr Lys Asn Leu Gly Glu
            340                 345                 350         
Pro Glu Asp Tyr Gly Arg Thr Ser Glu Thr Gln Glu Lys Glu Cys Glu
        355                 360                 365             
Thr Lys Asp Leu Pro Val Gln Tyr Gly Ser Arg Asn Gly Ser Glu Thr
    370                 375                 380                 
Ser Asp Met Arg Asp Glu Arg Lys Glu Arg Arg Gly Pro Glu Ala His
385                 390                 395                 400 
Gly Thr Ala Gly Gln Lys Glu Arg Asp Arg Lys Thr Arg Pro Leu Val
                405                 410                 415     
Leu Glu Thr Gln Thr Gln Asp Gly Lys Tyr Gln Glu Leu Gln Gly Leu
            420                 425                 430         
Ser Lys Ser Lys Asp Ala Glu Lys Gly Ser Glu Thr Gln Tyr Leu Ser
        435                 440                 445             
Ser Glu Gly Gly Asp Gln Thr His Pro Glu Leu Glu Gly Thr Ala Val
    450                 455                 460                 
Ser Gly Glu Glu Ala Glu His Thr Lys Glu Gly Thr Ala Glu Ala Phe
465                 470                 475                 480 
Val Asn Ser Lys Asn Ala Pro Ala Ala Glu Arg Thr Leu Gly Ala Arg
                485                 490                 495     
Glu Arg Thr Gln Asp Leu Ala Pro Leu Glu Lys Gln Ser Val Gly Glu
            500                 505                 510         
Asn Thr Arg Val Thr Lys Thr His Asp Gln Pro Val Glu Glu Glu Asp
        515                 520                 525             
Gly Tyr Gln Gly Glu Asp Pro Glu Ser Pro Phe Thr Gln Ser Asp Glu
    530                 535                 540                 
Gly Ser Ser Glu Thr Pro Asn Ser Leu Ala Ser Glu Glu Gly Asn Ser
545                 550                 555                 560 
Ser Ser Glu Thr Gly Glu Leu Pro Val Gln Gly Asp Ser Gln Ser Gln
                565                 570                 575     
Gly Asp Gln His Gly Glu Ser Val Gln Gly Gly His Asn Asn Asn Pro
            580                 585                 590         
Asp Thr Gln Arg Gln Gly Thr Pro Gly Glu Lys Asn Arg Ala Leu Glu
        595                 600                 605             
Ala Val Val Pro Ala Val Arg Gly Glu Asp Val Gln Leu Thr Glu Asp
    610                 615                 620                 
Gln Glu Gln Pro Ala Arg Gly Glu His Lys Asn Gln Gly Pro Gly Thr
625                 630                 635                 640 
Lys Gly Pro Gly Ala Ala Val Glu Pro Asn Gly His Pro Glu Ala Gln
                645                 650                 655     
Glu Ser Thr Ala Gly Asp Glu Asn Arg Lys Ser Leu Glu Ile Glu Ile
            660                 665                 670         
Thr Gly Ala Leu Asp Glu Asp Phe Thr Asp Gln Leu Ser Leu Met Gln
        675                 680                 685             
Leu Pro Gly Lys Gly Asp Ser Arg Asn Glu Leu Lys Val Gln Gly Pro
    690                 695                 700                 
Ser Ser Lys Glu Glu Lys Gly Arg Ala Thr Glu Ala Gln Asn Thr Leu
705                 710                 715                 720 
Leu Glu Ser Leu Asp Glu Asp Asn Ser Ala Ser Leu Lys Ile Gln Leu
                725                 730                 735     
Glu Thr Lys Glu Pro Val Thr Ser Glu Glu Glu Asp Glu Ser Pro Gln
            740                 745                 750         
Glu Leu Ala Gly Glu Gly Gly Asp Gln Lys Ser Pro Ala Lys Lys Glu
        755                 760                 765             
His Asn Ser Ser Val Pro Trp Ser Ser Leu Glu Lys Gln Met Gln Arg
    770                 775                 780                 
Asp Gln Glu Pro Cys Ser Val Glu Arg Gly Ala Val Tyr Ser Ser Pro
785                 790                 795                 800 
Leu Tyr Gln Tyr Leu Gln Glu Lys Ile Leu Gln Gln Thr Asn Val Thr
                805                 810                 815     
Gln Glu Glu His Gln Lys Gln Val Gln Ile Ala Gln Ala Ser Gly Pro
            820                 825                 830         
Glu Leu Cys Ser Val Ser Leu Thr Ser Glu Ile Ser Asp Cys Ser Val
        835                 840                 845             
Phe Phe Asn Tyr Ser Gln Ala Ser Gln Pro Tyr Thr Arg Gly Leu Pro
    850                 855                 860                 
Leu Asp Glu Ser Pro Ala Gly Ala Gln Glu Thr Pro Ala Pro Gln Ala
865                 870                 875                 880 
Leu Glu Asp Lys Gln Glu Asp Trp Ser Pro Glu His Ala Met Val Asn
                885                 890                 895     
Leu Tyr Ala Glu Val Lys Asn Ser Phe Lys Asn Thr Gly Thr Pro Gln
            900                 905                 910         
Arg Val Leu Pro Pro Val Val Trp Ser Pro Pro Ser Arg Lys Lys Pro
        915                 920                 925             
Met Leu Ser Ala Cys Asn Ser Met Met Phe Gly His Leu Ser Pro Val
    930                 935                 940                 
Arg Ile Pro His Leu Arg Gly Lys Phe Asn Leu Gln Leu Pro Ser Leu
945                 950                 955                 960 
Asp Glu Gln Val Ile Pro Ala Arg Leu Pro Lys Met Glu Val Arg Ala
                965                 970                 975     
Glu Glu Pro Lys Glu Ala Thr Glu Val Lys Asp Gln Val Glu Thr Gln
            980                 985                 990         
Gly Gln Glu Asp Asn Lys Arg Gly Pro Cys Ser Asn Gly Glu Ala Ala
        995                 1000                1005            
Ser Thr Ser Ser Leu Leu Glu Thr Gln Gly Asn Leu Thr Ser Ser Trp
    1010                1015                1020                
Tyr Asn Pro Arg Pro Leu Glu Gly Asn Val His Leu Lys Ser Leu Ile
1025                1030                1035                1040
Glu Lys Asn Gln Thr Asp Lys Ala Gln Val His Ala Val Ser Phe Tyr
                1045                1050                1055    
Ser Lys Asp His Glu Val Ala Ser Ser His Ser Pro Ala Gly Gly Ile
            1060                1065                1070        
Leu Ser Phe Gly Lys Pro Asp Pro Leu Pro Thr Val Leu Pro Ala Pro
        1075                1080                1085            
Val Pro Gly Cys Ser Leu Trp Pro Glu Lys Ala Ala Leu Lys Val Leu
    1090                1095                1100                
Gly Lys Asp His Leu Pro Ser Ser Pro Gly Leu Leu Met Val Gly Glu
1105                1110                1115                1120
Asp Met Gln Pro Lys Asp Pro Ala Ala Leu Gly Ser Ser Arg Ser Ser
                1125                1130                1135    
Pro Ser Arg Ala Ala Ser His Ser Ser His Lys Arg Lys Leu Ser Glu
            1140                1145                1150        
Pro Pro Leu Gln Leu Gln Pro Thr Pro Pro Leu Gln Leu Lys Trp Asp
        1155                1160                1165            
Arg Asp Glu Gly Pro Pro Pro Ala Lys Phe Pro Cys Leu Ser Pro Glu
    1170                1175                1180                
Ala Leu Leu Glu Thr Lys Arg Ala Ala
1185                1190            


<210> 2549
<211> 222
<212> PRT
<213> Homo sapiens

<400> 2549
Met Pro Leu Ile Pro Thr Tyr Thr Leu Ala Phe Pro His Val Lys Ser
 1               5                  10                  15      
Glu Ile Glu Glu Val Asn His Met Asp Pro Ser Lys Leu Lys Pro Ser
            20                  25                  30          
Gly Gln Gln Pro Arg Leu Tyr Ala His Thr Gly Ala Leu Glu Pro Thr
        35                  40                  45              
Cys Thr Cys Glu Asp Ser Gln Thr His Thr Ser Pro Ser Gly Ser Ile
    50                  55                  60                  
Leu Cys Thr Leu Pro Ser Ser Ala Ser Pro Glu Glu Glu Thr Val Pro
65                  70                  75                  80  
Gln Ser Glu Leu Gln Leu Gln Gln Ser Trp Arg Arg Ala Ser Glu Thr
                85                  90                  95      
Pro Glu Arg Val Arg Arg Gln Thr Ala Ala Thr Asn Thr Cys Val Tyr
            100                 105                 110         
Pro Ser Val Pro Ala Leu Leu Ser Val Gln Val Ser Ala Val Gly Ser
        115                 120                 125             
Tyr Arg Gln Glu Leu Pro Ile Pro Ala Arg Ser Pro Gly Ile Ser Ala
    130                 135                 140                 
Ser Ala Leu Met Leu Pro Gly Ala Phe Tyr Asp Tyr Pro Ser Gln Asp
145                 150                 155                 160 
Pro Thr Ala Glu Asp Pro Asp Arg Val Ala Trp Arg Asn Tyr Gly Ala
                165                 170                 175     
Pro Val Val Pro Ile Ile Trp Leu Ser Leu Thr Arg Pro Ser Ala Asn
            180                 185                 190         
Lys Lys Pro Lys Thr Asp Leu Asp Gln Asn Asn Leu Glu Tyr Arg Ser
        195                 200                 205             
Tyr Thr Met Ile Lys Arg Ile Ser Ile Leu Asp Phe Tyr Ser
    210                 215                 220         


<210> 2550
<211> 495
<212> PRT
<213> Homo sapiens

<400> 2550
Met Gln Trp Ser Pro Thr Pro Gly Ala Ser Ala Cys Leu Gly Trp Ala
 1               5                  10                  15      
Ser Ser Leu Ala Cys Ser Thr Ala Pro Thr Leu Leu Gly Arg Ala Gly
            20                  25                  30          
Arg Gly Pro Leu Met Ala Ala Lys Trp Phe Lys Glu Phe Pro Leu Asn
        35                  40                  45              
Leu Lys Thr Val Ser Glu Arg Ala Lys Pro Gly Gly Gly Gly Gly Lys
    50                  55                  60                  
Leu Arg Lys Asn Ser Glu Ala Gly Gly Ala Gly Pro Gly Pro Gly Lys
65                  70                  75                  80  
Gly Arg Lys Asn Ser Ala Ala Glu Leu Gly Ser Gly Arg Ala Gly Val
                85                  90                  95      
Gly Pro Lys Asp Ser Arg Leu Ser Arg Asp Ser Leu Gln Gly Leu Ile
            100                 105                 110         
Gln Ala Ala Ala Gly Lys Gly Arg Lys Asn Ser Arg Ala Thr Glu Glu
        115                 120                 125             
Glu Pro His Arg Gly Ala Thr Lys Ser Ser Gly Cys Ser Thr Tyr Ile
    130                 135                 140                 
Asn Arg Leu Ile Lys Val Asp Thr Gln Glu Lys Asn Gly Lys Ser Asn
145                 150                 155                 160 
Tyr Pro Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ala Ser
                165                 170                 175     
Ser Ser Pro Ser Ser Leu Gly Pro Glu Leu Asp Lys Gly Lys Ile Ile
            180                 185                 190         
Lys Gln Gln Glu Thr Val Ile Ile Leu Glu Asp Tyr Ala Asp Pro Tyr
        195                 200                 205             
Asp Ala Lys Arg Thr Lys Gly Gln Arg Asp Ala Glu Arg Val Gly Glu
    210                 215                 220                 
Asn Asp Gly Tyr Met Glu Pro Tyr Asp Ala Gln Gln Met Ile Thr Glu
225                 230                 235                 240 
Ile Arg Arg Arg Gly Ser Lys Asp Pro Leu Val Lys Ala Leu Gln Leu
                245                 250                 255     
Leu Asp Ser Pro Cys Glu Pro Ala Asp Gly Gly Leu Lys Ser Glu Thr
            260                 265                 270         
Leu Ala Lys Arg Arg Ser Ser Lys Asp Leu Leu Gly Lys Pro Pro Gln
        275                 280                 285             
Leu Tyr Asp Thr Pro Tyr Glu Pro Ala Glu Gly Gly Pro Arg Ala Glu
    290                 295                 300                 
Gly Lys Ala Arg Pro Pro Asp Ser Arg Leu Pro Glu Asn Asp Glu Arg
305                 310                 315                 320 
Pro Ala Ala Glu Tyr Glu Gln Pro Trp Glu Trp Lys Lys Glu Gln Ile
                325                 330                 335     
Val Arg Ala Leu Ser Val Gln Phe Glu Gly Ala Glu Arg Pro Ser Phe
            340                 345                 350         
Arg Glu Glu Thr Val Arg Gln His His Arg Gln Lys Ser Trp Thr Gln
        355                 360                 365             
Lys Ile Leu Lys Pro Ala Leu Ser Asp His Ser Glu Gly Glu Lys Val
    370                 375                 380                 
Asp Pro Gly Leu Pro Leu Glu Lys Gln Pro Trp Tyr His Gly Ala Ile
385                 390                 395                 400 
Ser Arg Ala Glu Ala Glu Ser Arg Leu Gln Pro Cys Lys Glu Ala Gly
                405                 410                 415     
Tyr Leu Val Arg Asn Ser Glu Ser Gly Asn Ser Arg Tyr Ser Ile Ala
            420                 425                 430         
Leu Lys Thr Ser Gln Gly Cys Val His Ile Ile Val Ala Gln Thr Lys
        435                 440                 445             
Asp Asn Lys Tyr Thr Leu Asn Gln Thr Ser Ala Val Phe Asp Ser Ile
    450                 455                 460                 
Pro Glu Val Val His Tyr Tyr Ser Asn Glu Lys Leu Pro Phe Lys Gly
465                 470                 475                 480 
Ala Glu His Met Thr Leu Leu Tyr Pro Val His Ser Lys Leu His
                485                 490                 495 


<210> 2551
<211> 250
<212> PRT
<213> Homo sapiens

<400> 2551
Met Val Gln His Gln Gln Val Arg Pro His Pro Arg Ser Asp Trp Ala
 1               5                  10                  15      
Leu Gln Cys Ser Tyr Ser Pro Phe Pro Val Pro Arg Leu Ser Ala Thr
            20                  25                  30          
Thr Thr Thr Ser Thr Asn Ala Asn Thr Ile Ala Val Ala Ile Asn Ala
        35                  40                  45              
Ala Ala His Pro Thr Arg Pro Ser Ala Asn Thr Ala Ala Thr Asn Ala
    50                  55                  60                  
Met Ser Ala Ala Ala Cys Pro Leu Pro Gly Pro Ala Pro Ala Ala Ala
65                  70                  75                  80  
Ala Asp Thr Ser Thr Thr Pro Pro Leu Ala Ala Ala Ile Val Pro Ala
                85                  90                  95      
Thr Ser Ser Cys Ser Glu Pro Thr Ile Ala Ala Pro Ala Thr Pro Arg
            100                 105                 110         
Asp Gly Ala Pro Glu Leu Gln Ser Pro Met Thr Arg Ile Phe Lys Arg
        115                 120                 125             
Pro Tyr Glu Thr Arg Leu Ser His Glu Pro Ser Gly Leu Gln Pro Gly
    130                 135                 140                 
Arg Ala Ala Ala Val Pro Gly Gln Ala Lys Ala Ala Ala Gln Val Gln
145                 150                 155                 160 
Gly Ala Pro Ala Pro Pro Glu Gln Arg Asp Pro Arg Glu Pro Arg Gln
                165                 170                 175     
Gln Lys Gly Cys Gly Lys Thr Ser Leu Leu Asp Ala Leu Thr Val Gly
            180                 185                 190         
Ser Gln Leu Cys Pro Leu Glu Thr Leu Trp Lys Pro Glu Ile Ala Leu
        195                 200                 205             
Glu Lys Arg Lys His Asp Leu Glu Val Pro Lys Pro Arg Leu His Leu
    210                 215                 220                 
Val Pro Leu Thr Thr Gln Gln His Leu Ala Pro Ala Ala Pro Gly His
225                 230                 235                 240 
Thr Val Leu Ala Arg Ile Cys Ser Gln Ser
                245                 250 


<210> 2552
<211> 139
<212> PRT
<213> Homo sapiens

<400> 2552
Met Leu Leu Thr Ile Ala Pro Pro Leu Asn Pro Thr Gln Met Ala Arg
 1               5                  10                  15      
Ser Ala Leu Gln Ser Pro Gly Ser Ala Tyr Leu Arg Thr Ser Leu Gln
            20                  25                  30          
Pro Leu Pro Leu Leu Leu Pro Gly Leu Cys Leu Thr Gly Lys Arg Asn
        35                  40                  45              
Ser Gln Ile Lys Leu Arg Pro Lys Pro Ala Leu Ala Gln Val Thr Leu
    50                  55                  60                  
Ile Pro Gly Ser Arg Pro Pro Leu Arg Thr Gln Thr Leu Arg Pro Thr
65                  70                  75                  80  
Arg Val Leu Arg Ala Ala Leu Asn Ser Gln Pro Asn Thr Ser Gly Gly
                85                  90                  95      
Arg Arg Ser Ala Thr Ser Pro Pro Arg Pro Gly Gly Gly Phe Lys Met
            100                 105                 110         
Gly Pro Leu Ser Ser Gly Ala Ala Arg Val Leu Gly Lys Ala Ala Ala
        115                 120                 125             
Thr Ser Ala Arg Arg Ala Leu Ser Met Val Leu
    130                 135                 


<210> 2553
<211> 219
<212> PRT
<213> Homo sapiens

<400> 2553
Met Gly Ala Arg Glu Ile Gly Leu Arg Glu His Asn Leu Ala Ala Gly
 1               5                  10                  15      
Thr Ile Thr Ala Arg Thr Glu Asn Arg Glu Leu Gln Asn Lys Arg Glu
            20                  25                  30          
Ile Ser Tyr Phe Ile Leu Leu Pro Gly Pro Thr Leu Leu Pro Ala Pro
        35                  40                  45              
Leu Thr His Ser Arg His Ile Tyr Arg Pro Arg Ala Leu Asn Gln Ala
    50                  55                  60                  
Ile Leu Ser Asp Lys Asp Ser Val Gly Ser Arg Lys Ile Lys Lys Lys
65                  70                  75                  80  
Thr Leu Leu Val Gly Val Asp Ser Pro Ala Ile Thr Leu Asp Thr Ala
                85                  90                  95      
Lys Thr Arg Pro Arg Lys Arg Ala Ser His Leu Phe Tyr Gln Gly Lys
            100                 105                 110         
Val Lys Phe Ser Lys Arg Thr Leu Ser Gln Leu Arg Val Leu Ala Asp
        115                 120                 125             
Leu Arg Ala Cys Gln Gly Ser Lys Glu Lys Asp Leu Gln Leu Pro Lys
    130                 135                 140                 
Val Thr Glu Met Asn Lys Lys Glu Pro Pro Met Asp Met Ser Glu Leu
145                 150                 155                 160 
Arg Met Lys Asp His Pro Arg Gln Lys Glu Cys Arg Lys Gln His Lys
                165                 170                 175     
Phe Thr Lys Ser Arg Glu Arg Ser Ala Lys Gln Glu Lys Ala Gly Gly
            180                 185                 190         
Glu Asp Gly Ala Asp Ser Gln Asp Leu Glu Cys Leu Leu Glu Glu Ser
        195                 200                 205             
Gly His Tyr Val Thr Gly Lys Gln Asn Tyr Val
    210                 215                 


<210> 2554
<211> 459
<212> PRT
<213> Homo sapiens

<400> 2554
Met Asn Thr Ile Ala Lys Thr Thr Pro His Thr Lys Phe Thr Lys Lys
 1               5                  10                  15      
Ser Glu Glu Arg Glu Met Pro Lys Gly Leu Lys Pro Ser Ser Gly Pro
            20                  25                  30          
Pro Pro Glu Glu Glu Glu Thr Leu Phe Thr Glu Met Ala Glu Met Ala
        35                  40                  45              
Glu Pro Ile Thr Lys Pro Ser Ala Leu Asp Ser Val Phe Gly Thr Ala
    50                  55                  60                  
Thr Leu Ser Pro Phe Glu Asn Phe Thr Leu Asp Pro Ala Asp Phe Phe
65                  70                  75                  80  
Leu Asn Cys Cys Asp Cys Cys Ser Pro Val Pro Gly Gln Lys Gly Glu
                85                  90                  95      
Pro Gly Glu Thr Gly Gln Pro Gly Pro Lys Gly Glu Ala Gly Asn Leu
            100                 105                 110         
Gly Ile Pro Gly Pro Pro Gly Val Val Gly Pro Gln Gly Pro Arg Gly
        115                 120                 125             
Tyr Lys Gly Glu Lys Gly Leu Lys Gly Glu Arg Gly Asp Gln Gly Val
    130                 135                 140                 
Pro Gly Tyr Pro Gly Lys Pro Gly Ala Gln Gly Glu Pro Gly Pro Lys
145                 150                 155                 160 
Gly Asp Lys Gly Asn Ile Gly Leu Gly Gly Val Lys Gly Gln Lys Gly
                165                 170                 175     
Ser Lys Gly Asp Thr Cys Gly Asn Cys Thr Lys Gly Glu Lys Gly Asp
            180                 185                 190         
Gln Gly Ala Met Gly Ser Pro Gly Leu His Gly Gly Pro Gly Ala Lys
        195                 200                 205             
Gly Glu Lys Gly Glu Met Gly Glu Lys Gly Glu Met Gly Asp Lys Gly
    210                 215                 220                 
Cys Cys Gly Asp Ser Gly Glu Arg Gly Gly Lys Gly Gln Lys Gly Glu
225                 230                 235                 240 
Gly Gly Met Lys Gly Glu Lys Gly Ser Lys Gly Asp Ser Gly Met Glu
                245                 250                 255     
Gly Lys Ser Gly Arg Asn Gly Leu Pro Gly Ala Lys Gly Asp Pro Gly
            260                 265                 270         
Ile Lys Gly Glu Lys Gly Glu Leu Gly Pro Pro Gly Leu Leu Gly Pro
        275                 280                 285             
Thr Gly Pro Lys Gly Asp Ile Gly Asn Lys Gly Val Arg Gly Pro Thr
    290                 295                 300                 
Gly Lys Lys Gly Ser Arg Gly Phe Lys Gly Ser Lys Gly Glu Leu Ala
305                 310                 315                 320 
Arg Val Pro Arg Ser Ala Phe Ser Ala Gly Leu Ser Lys Pro Phe Pro
                325                 330                 335     
Pro Pro Asn Ile Pro Ile Lys Phe Glu Lys Ile Leu Tyr Asn Asp Gln
            340                 345                 350         
Gly Asn Tyr Ser Pro Val Thr Gly Lys Phe Asn Cys Ser Ile Pro Gly
        355                 360                 365             
Thr Tyr Val Phe Ser Tyr His Ile Thr Val Arg Gly Arg Pro Ala Arg
    370                 375                 380                 
Ile Ser Leu Val Ala Gln Asn Lys Lys Gln Phe Lys Ser Arg Glu Thr
385                 390                 395                 400 
Leu Tyr Gly Gln Glu Ile Asp Gln Ala Ser Leu Leu Val Ile Leu Lys
                405                 410                 415     
Leu Ser Ala Gly Asp Gln Val Trp Leu Glu Val Ser Lys Asp Trp Asn
            420                 425                 430         
Gly Val Tyr Val Ser Ala Glu Asp Asp Ser Ile Phe Thr Gly Phe Leu
        435                 440                 445             
Leu Tyr Pro Glu Glu Thr Ser Gly Ile Ser Pro
    450                 455                 


<210> 2555
<211> 492
<212> PRT
<213> Homo sapiens

<400> 2555
Met Leu Ser Leu Glu Lys Ser Lys Ser Arg Gly Ala Ser Ala Asn Lys
 1               5                  10                  15      
Thr Gln Leu Val Glu Ser Leu Lys Lys Thr Thr Ser Gly Ser Thr Asn
            20                  25                  30          
Thr Leu Lys Gln His Gln Glu Gln Trp His Asp Val Cys Arg Gln Arg
        35                  40                  45              
Glu Pro Glu Pro Thr Arg Arg Leu Leu Ser Ala Pro Arg Ser Met Lys
    50                  55                  60                  
Lys Lys Thr Ile Gln Lys Cys Ile Met Ile Leu Arg Gly Ser Gly Lys
65                  70                  75                  80  
Tyr Met Arg Arg Asp Thr Lys Pro Glu Lys Thr Phe Arg Trp Ile Lys
                85                  90                  95      
Gln Ile Phe Gly Val Leu Leu Ile Leu Lys Gln Ser Arg Val Gly Asn
            100                 105                 110         
Trp Lys Tyr Leu Glu Glu Asp Ala Glu Glu Lys Ser Ala Arg Ile Lys
        115                 120                 125             
Pro Cys Phe Arg Arg Ser Pro Val Thr Glu Gly Glu Trp Ser Pro Trp
    130                 135                 140                 
Arg Asp Trp Arg Gln Thr Asn Gly Leu Ser Leu Pro Ile Glu Ile Lys
145                 150                 155                 160 
Thr Thr Leu Phe Ala Gln Glu Glu Ala Gly Ser Arg Asp Leu Gly Ile
                165                 170                 175     
Ser Lys Tyr Gly His Glu Ser Gln Met Asn Gly Thr Gln Ile His Thr
            180                 185                 190         
Leu Ser Thr Cys Tyr Ser Thr Gly Tyr Arg Tyr Phe Phe Val Val Glu
        195                 200                 205             
Glu Asp Asn Thr Pro Leu Ser Val Thr Val Thr Pro Cys Asp Ala Pro
    210                 215                 220                 
Leu Glu Trp Lys Leu Ser Leu Gln Glu Leu Pro Glu Asp Arg Ser Gly
225                 230                 235                 240 
Glu Gly Ser Gly Cys Gly Gln Lys Gly Glu Pro Arg Ala His Asn Ala
                245                 250                 255     
Thr Lys Pro His Ser Lys Phe Ser Ser Leu Gln Ser Ala Ser Lys Lys
            260                 265                 270         
Thr Ala Gly Thr Cys Asn His Ser Phe Gly Leu Leu Gly Tyr Arg Gly
        275                 280                 285             
Arg Gly Asp Ser Ala Gln Leu Glu Ser Ser Gln Thr Pro Thr Lys Asn
    290                 295                 300                 
Ser Cys Ala Ala Trp Thr Ser Ser Phe Ser Pro Tyr Thr Gln Thr Pro
305                 310                 315                 320 
Ser Ala Lys Pro Gln Ser Arg Arg Leu Ser Leu Ala Ala Gly Gly Gly
                325                 330                 335     
His Glu Pro Gly Lys Gly Gly Asn Ser Pro Leu Gly Arg Arg Ala Lys
            340                 345                 350         
Cys Val Lys Thr Val Leu Val Met Ala Ile Ile Ser Ile Leu Glu Asp
        355                 360                 365             
Ala Ser Ile Ser Lys Ile Leu Pro Leu Asp Cys Gly His Ser Glu Asp
    370                 375                 380                 
Leu Ser Leu Cys His Gln Ser Asp Leu Ala Pro Ser Arg Arg Lys Glu
385                 390                 395                 400 
Ala Ala Lys Asp Thr Pro Ala Phe Gly Thr Gly Leu Gly Thr Gly Thr
                405                 410                 415     
Ala Asn Ala Arg Cys His Leu Arg Arg Gly Lys Lys Tyr Val Lys Tyr
            420                 425                 430         
Thr Gln Pro Ser Lys Gln Thr Tyr Thr Glu Met Glu Arg Leu Asn Glu
        435                 440                 445             
Glu Leu His Glu Leu Lys Glu Glu Asn Lys Leu Leu Lys Gly Lys Asn
    450                 455                 460                 
Thr Leu Ala Asn Lys Glu Lys Glu His Tyr Glu Cys Glu Ile Lys Arg
465                 470                 475                 480 
Leu Asn Lys Val Ser Val Arg Ser Ser Met Gly Asp
                485                 490         


<210> 2556
<211> 772
<212> PRT
<213> Homo sapiens

<400> 2556
Met Gly Arg Thr Leu Gln Asn Thr Met Val Asn Leu Gly Leu Gln Asn
 1               5                  10                  15      
Ala Cys Asp Glu Ala Ile Tyr Gln Leu Gly Leu Asp Leu Glu Glu Leu
            20                  25                  30          
Glu Glu Ile Glu Glu Asp Ala Gly Leu Gly Asn Gly Gly Leu Gly Arg
        35                  40                  45              
Leu Ala Ala Cys Phe Leu Asp Ser Met Ala Thr Leu Gly Leu Ala Ala
    50                  55                  60                  
Tyr Gly Tyr Gly Ile Arg Tyr Glu Phe Gly Ile Phe Asn Gln Lys Ile
65                  70                  75                  80  
Val Asn Gly Trp Gln Val Glu Glu Ala Asp Asp Trp Leu Arg Tyr Gly
                85                  90                  95      
Asn Pro Trp Glu Lys Ala Arg Pro Glu Tyr Met Leu Pro Val His Phe
            100                 105                 110         
Tyr Gly Arg Val Glu His Thr Pro Asp Gly Val Lys Trp Leu Asp Thr
        115                 120                 125             
Gln Val Val Leu Ala Met Pro Tyr Asp Thr Pro Val Pro Gly Tyr Lys
    130                 135                 140                 
Asn Asn Thr Val Asn Thr Met Arg Leu Trp Ser Ala Lys Ala Pro Asn
145                 150                 155                 160 
Asp Phe Lys Leu Gln Asp Phe Asn Val Gly Asp Tyr Ile Glu Ala Val
                165                 170                 175     
Leu Asp Arg Asn Leu Ala Glu Asn Ile Ser Arg Val Leu Tyr Pro Asn
            180                 185                 190         
Asp Asn Phe Phe Glu Gly Lys Glu Leu Arg Leu Lys Gln Glu Tyr Phe
        195                 200                 205             
Val Val Ala Ala Thr Leu Gln Asp Ile Ile Arg Arg Phe Lys Ser Ser
    210                 215                 220                 
Lys Phe Gly Cys Arg Asp Pro Val Arg Thr Cys Phe Glu Thr Phe Pro
225                 230                 235                 240 
Asp Lys Val Ala Ile Gln Leu Asn Asp Thr His Pro Ala Leu Ser Ile
                245                 250                 255     
Pro Glu Leu Met Arg Ile Leu Val Asp Val Glu Lys Val Asp Trp Asp
            260                 265                 270         
Lys Ala Trp Glu Ile Thr Lys Lys Thr Cys Ala Tyr Thr Asn His Thr
        275                 280                 285             
Val Leu Pro Glu Ala Leu Glu Arg Trp Pro Val Ser Met Phe Glu Lys
    290                 295                 300                 
Leu Leu Pro Arg His Leu Glu Ile Ile Tyr Ala Ile Asn Gln Arg His
305                 310                 315                 320 
Leu Asp His Val Ala Ala Leu Phe Pro Gly Asp Val Asp Arg Leu Arg
                325                 330                 335     
Arg Met Ser Val Ile Glu Glu Gly Asp Cys Lys Arg Ile Asn Met Ala
            340                 345                 350         
His Leu Cys Val Ile Gly Ser His Ala Val Asn Gly Val Ala Arg Ile
        355                 360                 365             
His Ser Glu Ile Val Lys Gln Ser Val Phe Lys Asp Phe Tyr Glu Leu
    370                 375                 380                 
Glu Pro Glu Lys Phe Gln Asn Lys Thr Asn Gly Ile Thr Pro Arg Arg
385                 390                 395                 400 
Trp Leu Leu Leu Cys Asn Pro Gly Leu Ala Asp Thr Ile Val Glu Lys
                405                 410                 415     
Ile Gly Glu Glu Phe Leu Thr Asp Leu Ser Gln Leu Lys Lys Leu Leu
            420                 425                 430         
Pro Leu Val Ser Asp Glu Val Phe Ile Arg Asp Val Ala Lys Val Lys
        435                 440                 445             
Gln Glu Asn Lys Leu Lys Phe Ser Ala Phe Leu Glu Lys Glu Tyr Lys
    450                 455                 460                 
Val Lys Ile Asn Pro Ser Ser Met Phe Asp Val His Val Lys Arg Ile
465                 470                 475                 480 
His Glu Tyr Lys Arg Gln Leu Leu Asn Cys Leu His Val Val Thr Leu
                485                 490                 495     
Tyr Asn Arg Ile Lys Arg Asp Pro Ala Lys Ala Phe Val Pro Arg Thr
            500                 505                 510         
Val Met Ile Gly Gly Lys Ala Ala Pro Gly Tyr His Met Ala Lys Leu
        515                 520                 525             
Ile Ile Lys Leu Val Thr Ser Ile Gly Asp Val Val Asn His Asp Pro
    530                 535                 540                 
Val Val Gly Asp Arg Leu Lys Val Ile Phe Leu Glu Asn Tyr Arg Val
545                 550                 555                 560 
Ser Leu Ala Glu Lys Val Ile Pro Ala Ala Asp Leu Ser Gln Gln Ile
                565                 570                 575     
Ser Thr Ala Gly Thr Glu Ala Ser Gly Thr Gly Asn Met Lys Phe Met
            580                 585                 590         
Leu Asn Gly Ala Leu Thr Ile Gly Thr Met Asp Gly Ala Asn Val Glu
        595                 600                 605             
Met Ala Glu Glu Ala Gly Ala Glu Asn Leu Phe Ile Phe Gly Leu Arg
    610                 615                 620                 
Val Glu Asp Val Glu Ala Leu Asp Arg Lys Gly Tyr Asn Ala Arg Glu
625                 630                 635                 640 
Tyr Tyr Asp His Leu Pro Glu Leu Lys Gln Ala Val Asp Gln Ile Ser
                645                 650                 655     
Ser Gly Phe Phe Ser Pro Lys Glu Pro Asp Cys Phe Lys Asp Ile Val
            660                 665                 670         
Asn Met Leu Met His His Asp Arg Phe Lys Val Phe Ala Asp Tyr Glu
        675                 680                 685             
Ala Tyr Met Gln Cys Gln Ala Gln Val Asp Gln Leu Tyr Arg Asn Pro
    690                 695                 700                 
Lys Glu Trp Thr Lys Lys Val Ile Arg Asn Ile Ala Cys Ser Gly Lys
705                 710                 715                 720 
Phe Ser Ser Asp Arg Thr Ile Thr Glu Tyr Ala Arg Glu Ile Trp Gly
                725                 730                 735     
Val Glu Pro Ser Asp Leu Gln Leu Gln His Leu Pro His Pro Glu Trp
            740                 745                 750         
Glu Ser Gly Gly Ala Thr Cys Trp Ala Pro Pro Glu Leu Cys Thr His
        755                 760                 765             
Leu Ala Met Tyr
    770         


<210> 2557
<211> 445
<212> PRT
<213> Homo sapiens

<400> 2557
Met Val Ser Met Lys Cys Ser Ala Pro Leu Leu Ala Gln Ala Asn Gln
 1               5                  10                  15      
Asp Gly Ala Ile Arg Ile Phe Phe Gly Phe His Val Leu Gly Ser His
            20                  25                  30          
His Gly Cys Ala Trp Gly Pro Ala Ser Thr Ala Ala Gly Ser Ile Gln
        35                  40                  45              
Pro Val Asp Pro Leu Ser Pro Ser Ser Leu Gln Gln Ala Pro Arg Pro
    50                  55                  60                  
Trp Ala Ala Ala Ala Gly Pro Lys Gln Asn Asp Pro Ile Glu Pro Ser
65                  70                  75                  80  
Glu Lys Ser Glu Trp Ala Phe Ser Lys Ala Ser Lys Ala Thr Leu Leu
                85                  90                  95      
Ser Cys Ser Glu Ser Phe Asp Gly Ser Leu Leu Pro Trp His Glu Gly
            100                 105                 110         
Leu Ala Leu Gln Ala Gly Ser Asp Glu Lys Glu Leu Glu Gly Arg Leu
        115                 120                 125             
Val Leu Leu Phe Lys Ser Arg Asp Ser Gln Glu Arg Arg Thr His Val
    130                 135                 140                 
Leu Lys Lys Asn Pro Gly Leu Val Arg Leu Asn Val Cys Lys Ser Pro
145                 150                 155                 160 
Leu Glu Arg Leu Arg Ile Ser His Ala Lys Ile Leu Asp Val Leu Glu
                165                 170                 175     
Gln Asn Pro Lys Asn Ala Thr Tyr Arg Lys His Thr Glu Leu Phe Thr
            180                 185                 190         
Asn Glu Lys Leu Val Lys Met Val Lys Trp Leu Lys Gln Asn Gln Met
        195                 200                 205             
Leu Lys Asn Lys Lys Thr Asp Phe Lys Cys Leu Cys Gly Ala Glu Cys
    210                 215                 220                 
Asp Glu Ala Cys Leu Gln Val His Val Ala Val Gly Gly Trp Val Trp
225                 230                 235                 240 
Leu Gly Gly Ala Val Tyr Asp Ser Ser Gly Pro Cys Thr His Met Ser
                245                 250                 255     
Ser Pro Thr Glu His Arg Leu Gln Thr Pro Ile Phe Leu Ala Gln Ala
            260                 265                 270         
Gln Ala Gln Glu Ala Asn Ser Thr Ala Phe Lys Ile Gln Pro Arg Asp
        275                 280                 285             
Lys Ser Asp His Ser Ser Val Val Glu Ala Thr Gly Gln Val Gln Thr
    290                 295                 300                 
Glu Asp Lys Leu Tyr Arg Arg Ser Pro Val Thr Lys Ala Glu Ala Pro
305                 310                 315                 320 
Ile Thr Lys Ala Pro Asp Pro Pro Ser Ile Val Asn Pro Ser Ala Glu
                325                 330                 335     
Ser Pro Glu Asp Tyr Gln Val Thr Arg Gln Gln Gly Glu Ala Lys Val
            340                 345                 350         
Lys Pro Ala Ser Ser Gly Gly Ala Phe Ala Phe Ser Leu Tyr Ala Pro
        355                 360                 365             
Gly Ala Pro Glu Asp Gly Cys Gly Phe Ala Asp Arg Glu Ser Ala Ala
    370                 375                 380                 
Trp Thr Cys Gln Arg Cys Arg Ser Glu Val Ser Thr Gly Glu Pro Gly
385                 390                 395                 400 
Trp Ala Pro Pro Gly Arg Asp Ile Cys Phe Gln Ser Ala Ala Leu Leu
                405                 410                 415     
Pro Glu Lys Gly Thr Ile Glu Phe Arg Thr Pro Ala His Arg Leu Lys
            420                 425                 430         
Ser Lys Leu Leu Ser Gln Ala Pro Lys Ala Ser Val Thr
        435                 440                 445 


<210> 2558
<211> 237
<212> PRT
<213> Homo sapiens

<400> 2558
Met Ala Ala Ala Ser Gly Ser Val Leu Gln Arg Cys Ile Val Ser Pro
 1               5                  10                  15      
Ala Gly Arg His Ser Ala Ser Leu Ile Phe Leu His Gly Ser Gly Asp
            20                  25                  30          
Ser Gly Gln Gly Leu Arg Met Trp Ile Lys Gln Val Leu Asn Gln Asp
        35                  40                  45              
Leu Thr Phe Gln His Ile Lys Ile Ile Tyr Pro Thr Ala Pro Pro Arg
    50                  55                  60                  
Ser Tyr Thr Pro Met Lys Gly Gly Ile Ser Asn Val Trp Phe Asp Arg
65                  70                  75                  80  
Phe Lys Ile Thr Asn Asp Cys Pro Glu His Leu Glu Ser Ile Asp Val
                85                  90                  95      
Met Cys Gln Val Leu Thr Asp Leu Ile Asp Glu Glu Val Lys Ser Gly
            100                 105                 110         
Ile Lys Lys Asn Arg Ile Leu Ile Gly Gly Phe Ser Met Gly Gly Cys
        115                 120                 125             
Met Ala Ile His Leu Ala Tyr Arg Asn His Gln Asp Val Ala Gly Val
    130                 135                 140                 
Phe Ala Leu Ser Ser Phe Leu Asn Lys Ala Ser Ala Val Tyr Gln Ala
145                 150                 155                 160 
Leu Gln Lys Ser Asn Gly Val Leu Pro Glu Leu Phe Gln Cys His Gly
                165                 170                 175     
Thr Ala Asp Glu Leu Val Leu His Ser Trp Ala Glu Glu Thr Asn Ser
            180                 185                 190         
Met Leu Lys Ser Leu Gly Val Thr Thr Lys Phe His Ser Phe Pro Asn
        195                 200                 205             
Val Tyr His Glu Leu Ser Lys Thr Glu Leu Asp Ile Leu Lys Leu Trp
    210                 215                 220                 
Ile Leu Thr Lys Leu Pro Gly Glu Met Glu Lys Gln Lys
225                 230                 235         


<210> 2559
<211> 325
<212> PRT
<213> Homo sapiens

<400> 2559
Met Val Arg Ala Leu Asn His Thr Glu Ile Leu Lys Leu Asn Asn Thr
 1               5                  10                  15      
Ser Gln Gln Leu Leu Glu Ile Lys Ser Lys Asn Val Phe Gln Tyr Lys
            20                  25                  30          
Ala Met Val Gly Arg Gly Val Leu Lys Gln Glu Gly Arg Gly Pro Pro
        35                  40                  45              
Ser Ser Pro Pro Ser Ser Pro Pro Ser Ser Pro Pro Ala Ala Pro Gln
    50                  55                  60                  
Gln Pro Pro Ser Ser Pro Pro Ser Ser Pro Pro Ser Ser Pro Pro Ala
65                  70                  75                  80  
Ala Pro Leu Ala Ala Pro Gln Gln Pro Pro Ser Ser Pro Pro Ser Ser
                85                  90                  95      
Pro Pro Ser Ser Pro Pro Ala Ala Pro Leu Ala Ala Pro Tyr Pro Pro
            100                 105                 110         
Ala Ala Pro Pro Ala Ala Pro Gln Gln Gln Pro Ala Ala Pro Ala Glu
        115                 120                 125             
Pro Ala Ala Thr Phe Glu Lys Lys Thr Ala Val Pro Pro Thr Tyr Ala
    130                 135                 140                 
Asp Leu Gly Lys Ser Ala Arg Asp Leu Asp Leu Lys Thr Lys Ser Glu
145                 150                 155                 160 
Asp Gly Ser Glu Phe Thr Ser Ser Gly Ser Ala Asn Thr Glu Thr Thr
                165                 170                 175     
Lys Val Thr Gly Ser Leu Glu Thr Arg Tyr Arg Trp Thr Asp Tyr Gly
            180                 185                 190         
Ser Arg Ser Thr Glu Lys Trp Asn Pro Asp Asn Thr Leu Gly Thr Glu
        195                 200                 205             
Met Ser Val Asp Val Gly Tyr Arg Thr Asp Glu Phe Gln Leu His Thr
    210                 215                 220                 
Thr Val Asn Asp Gly Thr Glu Phe Gly Gly Ser Ile Tyr Gln Lys Val
225                 230                 235                 240 
Asn Lys Lys Leu Glu Thr Ala Val Asn Leu Val Trp Thr Ala Gly Asn
                245                 250                 255     
Ser Asn Thr Arg Phe Gly Thr Ala Ala Lys Tyr Gln Thr Asp Pro His
            260                 265                 270         
Ala Cys Phe Ser Thr Lys Val Asn Asn Ser Ser Leu Ile Gly Leu Gly
        275                 280                 285             
Tyr Thr Gln Thr Leu Gln Pro Gly Ile Lys Leu Thr Leu Ser Ala Leu
    290                 295                 300                 
Leu Asp Gly Lys Asn Val Lys Ala Gly Gly His Lys Leu Gly Leu Gly
305                 310                 315                 320 
Leu Lys Phe Gln Ala
                325 


<210> 2560
<211> 301
<212> PRT
<213> Homo sapiens

<400> 2560
Met His Gln Asn Val Leu Ile Cys Ile Ser Ser Glu Met Pro Gly Gly
 1               5                  10                  15      
Pro Leu His Phe Leu Leu Glu Ser Ala Ser Pro Gln Leu Pro Leu Ser
            20                  25                  30          
Glu Gln Gln Pro Lys Thr His Gln Lys Ser Val Asp Ser Ala His Ile
        35                  40                  45              
Pro Asp Ser Gln Ala Ser Ala Leu Leu Gly Pro Ile Gln Arg Ala Asp
    50                  55                  60                  
Ser Thr Glu Ser Tyr Arg Leu Gln Asp Ser Ser Pro Met Pro Pro Ile
65                  70                  75                  80  
Arg Glu Gly Asn Val Phe Ile Pro Trp Ser Leu Lys Lys Ile Leu Pro
                85                  90                  95      
Gly Ala Thr Gly Leu Ser Ser Thr Pro Asp Thr Arg Ser Pro Val Arg
            100                 105                 110         
Cys Val Trp Pro Gln Leu Ala Glu Glu Cys Thr Cys Gln Thr Leu Arg
        115                 120                 125             
Gly Phe Glu Glu His Ser Ser Ser Lys Met Gly Thr Gly Ala Ser Glu
    130                 135                 140                 
Lys Gln Ala Glu Gln Lys Val Arg Arg Ala Phe Glu Ala Ser Glu Glu
145                 150                 155                 160 
Ala His Gly Thr Leu Ala Ala Ser Thr Pro Trp Val Ala Met Gly Ser
                165                 170                 175     
Ala Tyr Gly Ser Cys Thr Cys Leu Gly Ala Gln Pro Val Thr Asp Leu
            180                 185                 190         
Ala Leu Trp Pro Val Ile Tyr Ser Cys Met Gly Phe Ser Pro Gln Ala
        195                 200                 205             
Tyr Pro Ala Phe Trp Ala Tyr Pro Trp Val Leu Tyr Gly Gly Tyr Leu
    210                 215                 220                 
Trp Met Gly Tyr Pro Pro Pro Ala Ala Leu Val Pro Ser Val Trp Leu
225                 230                 235                 240 
Tyr Trp Arg Gly Ala Ser Ser Phe Asp Pro Leu Ile Gly Ser Pro Tyr
                245                 250                 255     
Leu Ala Ala Leu Ala Pro Asn Leu Phe Pro Phe Pro Met Lys Phe Pro
            260                 265                 270         
Pro Thr Tyr Ser Leu Ala Ser Pro Thr Leu Gly Gly Ala Thr Ser Ser
        275                 280                 285             
His Cys Pro Gln Arg Gly His Pro Glu Glu Leu Pro Thr
    290                 295                 300     


<210> 2561
<211> 180
<212> PRT
<213> Homo sapiens

<400> 2561
Met Lys Ser Val Ala Asn Arg Gln Ser Leu Ala Leu Lys Met Phe Ile
 1               5                  10                  15      
Val Gly His Glu Gly Arg Ser Val Asp Gly Ser Val Gln Thr Pro Ile
            20                  25                  30          
Cys Arg Arg Ile Gln Ser Leu Asn Ser Leu His Leu Pro Glu Arg Gln
        35                  40                  45              
His Ser Arg Pro Ser Ser Val Pro Ser Leu Ala Asp Gly Ala His Gly
    50                  55                  60                  
Gln Asn Glu Lys Asp Met Ser Leu Lys Ile Ser His Arg Ala Ser Arg
65                  70                  75                  80  
Gln Arg Val His Arg Pro His Gln Asp Gln Gly Arg Glu His Gln Tyr
                85                  90                  95      
Lys Asn Thr Ser Asn Val Cys His Lys Ala Ile Leu Thr Ala Pro Ser
            100                 105                 110         
Pro Gly Gly Gly Gly Arg Leu Arg Gly His Lys Ser Glu Leu Thr Ala
        115                 120                 125             
Ala Val Met Gln Arg Val Leu Pro Gln Asp Val His Pro Asp Thr Arg
    130                 135                 140                 
Gly Lys Lys Ser His Trp Ala Thr Gln Ala Ser Ala Pro His Val Leu
145                 150                 155                 160 
Thr Pro Pro Thr Thr Ala Leu Pro Leu Gln Leu Arg Pro Lys Leu Pro
                165                 170                 175     
Ser Asn Lys Pro
            180 


<210> 2562
<211> 255
<212> PRT
<213> Homo sapiens

<400> 2562
Met Phe Ser Ala Gly Gly Thr Gly Ala Val Gly Ala Pro Gln Ala Cys
 1               5                  10                  15      
Arg Ser Arg Asp Arg Ala Pro Ala Thr Ala Asp Met Glu Ala Gly Met
            20                  25                  30          
Val Gln Gly Ser Trp Ser Pro Glu Pro Pro Ala His Ala Ser Gly Lys
        35                  40                  45              
Leu Arg Glu Thr Trp Ala Gly Pro Val Pro Ala Arg Ser Gly His Thr
    50                  55                  60                  
Ala Lys Val Leu Asp Leu Arg Met Thr Ser Arg Val Phe Arg Lys Glu
65                  70                  75                  80  
Glu Asp Ser Ser His Gly Ala Pro Glu Gln Ile Gly Leu Ser Arg His
                85                  90                  95      
Asn Cys Ala Val Val Ala Val Ser Ala Gly Arg Ala Leu Pro Glu Ala
            100                 105                 110         
Gln Gly Pro Ser Leu Ile Arg Pro Pro Arg Ala Leu Ile Leu Ser Pro
        115                 120                 125             
Arg Ala Ile Pro Pro Ala Arg Asp Leu Phe Ser Ser Gly Gln Pro Pro
    130                 135                 140                 
Glu Glu Gly Asp Leu Arg Gly Ser His Ile His Gln Glu His Ser Val
145                 150                 155                 160 
Lys Gln Asp Gln Ser Val Leu Ala Val Ser Arg Pro Gln Pro Thr Leu
                165                 170                 175     
Lys Pro Glu Arg Asn Thr Arg Ser Pro Pro Gln Ala Arg Gly Pro Gln
            180                 185                 190         
Leu Pro Gln Gly Pro Leu Thr Ser Cys His Ser Asp Lys Ala Gly Arg
        195                 200                 205             
Ile Gln Val Pro Ser Val Thr Arg Lys Arg Phe Gly Gly Ser Gln Val
    210                 215                 220                 
Pro Ser Pro Ser Pro Trp Ser Val Thr Asp Asp Gly Arg Phe Arg Arg
225                 230                 235                 240 
Ser Pro Pro Gly Ser Ala Gln Ser Leu Pro Val Ser His Leu Gly
                245                 250                 255 


<210> 2563
<211> 898
<212> PRT
<213> Homo sapiens

<400> 2563
Met Cys Gln Asp Glu Thr Ala Leu Leu Gly Ala Gly Lys Arg Gly Gly
 1               5                  10                  15      
Phe Leu Leu Arg Ile Pro Gly Ala Gly Val Gly Glu Arg Val Met Leu
            20                  25                  30          
Gln Thr Pro Leu Asp Trp Ala Cys Ser Ile Leu Pro Pro Met Lys His
        35                  40                  45              
Cys Thr His Leu Ser Glu Ala Asp Ala Ser Val Ala Pro Gly Thr Met
    50                  55                  60                  
Leu Pro Ser Asp Arg Cys Pro Leu Pro Asp Leu Arg Arg Tyr Gln Gly
65                  70                  75                  80  
Val Ile Arg Gly Gln Asn Arg Ala Ile Trp Ser His Gly Trp Arg Ser
                85                  90                  95      
Leu Cys Val His Thr Ala Leu Asn Thr Ser Arg Ala Arg Thr Trp Pro
            100                 105                 110         
Arg Ser Lys Gln Ser Gly Ala Val Arg Phe Gln Ser Gln Arg Val Arg
        115                 120                 125             
Ser Ser Val Cys Thr Glu Ala Leu Arg Arg Pro Arg Ala Leu Gly Lys
    130                 135                 140                 
Ala Thr Cys Gln His Ser Leu Val Leu Pro Glu Leu Leu Leu Gln Gly
145                 150                 155                 160 
Lys Asp Ser Leu Leu Lys Thr Ile Asp Arg Leu Thr Lys Met His Ala
                165                 170                 175     
Thr Glu Glu His Gly His Ile Gly Asn Pro Thr Thr Val Gln Thr Gly
            180                 185                 190         
Asp Gly Ser Leu Leu Cys Ser Glu Ala Ala Ser Pro Gly Lys Trp Met
        195                 200                 205             
Asn Gly Thr Ala Arg Asp Gly Glu Ala Ser Arg Leu Lys Leu Thr Leu
    210                 215                 220                 
Gly Asp Ser Thr Phe Lys Val Leu Phe Ser Phe His Phe Leu Arg Ile
225                 230                 235                 240 
Ala Ala Glu Gln Ser Arg Met Glu Gly Gly Phe Val Leu Leu Pro Ile
                245                 250                 255     
Arg Val Pro Gly Arg Phe Phe Ile Arg Cys Pro Leu Leu Gly Ala Val
            260                 265                 270         
Leu Ala Val Val Glu Leu Glu Ala Phe Ser Lys Gly Ser Glu Ala Ala
        275                 280                 285             
His Leu Glu Phe Ser Ala Leu Pro Thr Ala Arg Ser Asn Leu His Ile
    290                 295                 300                 
Ala Phe Ser Pro Ala Arg Ser Trp Arg Leu Leu Ser Ser Asp Pro Pro
305                 310                 315                 320 
Gln Arg Ala Tyr Arg Leu Ser Ser His Leu Thr Val Gln Glu Lys Arg
                325                 330                 335     
Glu Arg Arg Pro Leu Pro Leu Leu Tyr Ile Cys Pro Arg Asp Pro Leu
            340                 345                 350         
Lys Glu Glu Cys Glu Lys Gly Arg Thr Ala Glu Thr Pro Pro Asn Gly
        355                 360                 365             
Arg Ser Ser Val Ser Gly Met Leu Gly Leu Gly Gly Val Ser Gln Gly
    370                 375                 380                 
Cys Pro Ser Trp Ser Asp Leu His Pro Val Lys Ile Leu Leu Arg Ala
385                 390                 395                 400 
Cys Arg Asp His Gly Asn Arg Lys Val Leu Thr Leu Gln Tyr Phe Met
                405                 410                 415     
Asp Gly Arg Ser His Phe Gln Asp Tyr Gly Ala Ala Phe Tyr Ala Asn
            420                 425                 430         
Arg Asn Ile Arg Ile Ser Lys Tyr Arg Arg Lys Lys Pro Ser Gly Ala
        435                 440                 445             
Arg Glu Glu Glu Glu Thr Ile Pro Glu His Leu Gln Cys Lys Pro Tyr
    450                 455                 460                 
Trp Thr Pro Glu Pro Pro Ser Ser Ala Val Glu Ser Ile Leu Leu Leu
465                 470                 475                 480 
Leu His Leu Arg Gly Asn Leu Trp Met Cys Asn Leu Phe Leu Lys Ala
                485                 490                 495     
Gln Thr His Pro Ser Asp Tyr Thr Gly Thr Pro Glu Gly Ser Thr Lys
            500                 505                 510         
Pro Arg Glu Ser Gln Asn Pro Gly Val Ala Arg Glu Ser Gly Phe Thr
        515                 520                 525             
Ile Thr Ser Leu Pro Thr His Ser Pro Gln Lys Glu Pro Ser Leu Gly
    530                 535                 540                 
Trp Gly Arg Arg Glu Gln Ser Phe Tyr Arg Gly Ile Leu Arg Arg Gly
545                 550                 555                 560 
Pro Trp Lys Pro His Ser Ser Ser Cys Val Pro Gly Gly Glu Pro Gly
                565                 570                 575     
Arg Glu Ala Gly Val Gly Ala His Ala Leu Pro Pro Ser Pro Trp Pro
            580                 585                 590         
Leu Arg Leu Cys Val Gly Ala His Ala Leu Pro Pro Ser Pro Trp Ala
        595                 600                 605             
Leu Arg Leu Cys Val Gly Ala His Ala Leu Pro Pro Pro Ser Ile Ser
    610                 615                 620                 
Val Ala Phe Ala Ser Leu Cys Gly Cys Thr Cys Ala Pro Ser Ile Ser
625                 630                 635                 640 
Val Ala Phe Ala Ser Leu Cys Gly Cys Thr Cys Ala Pro Ser Ile Ser
                645                 650                 655     
Val Ala Phe Ala Ser Leu Cys Gly Cys Thr Cys Ala Pro Ser Ile Ser
            660                 665                 670         
Val Ala Phe Ala Ser Leu Ser Gly Cys Thr Cys Pro Pro Ser Ile Ser
        675                 680                 685             
Val Ala Phe Ala Ser Leu Ser Gly Cys Thr Cys Ala Pro Ser Ile Ser
    690                 695                 700                 
Val Ala Phe Ala Ser Leu Ser Gly Cys Thr Arg Ser Phe Ser Ile Leu
705                 710                 715                 720 
Met Gly Ser Ala Leu Cys Leu Cys Thr Arg Ser Cys Ser Val Phe Gly
                725                 730                 735     
Pro Glu Asn Cys Pro Cys Gly Gly Gly Gln Ala Arg Ala Gln Ala Thr
            740                 745                 750         
Gly Arg Arg Pro Ile Thr Leu Gly Ser Gln Gly Trp Cys Leu Gln Ala
        755                 760                 765             
Leu Thr Trp Asn Ser Leu Lys Arg Leu Leu Thr Gly Met Met Ala Ala
    770                 775                 780                 
Lys Gly Thr Ile Cys Glu Gln Trp Pro Met Cys Arg Pro Pro Arg Thr
785                 790                 795                 800 
Arg Pro Ala Leu Cys Ser Gly Arg Ala Glu Gln Ala Arg Pro Gly Gln
                805                 810                 815     
Val Gly Gly Cys Gly Gln Gly Pro Gly His Leu His Pro Glu His Gln
            820                 825                 830         
Val Glu Asp Glu Lys Glu Asn Pro Gly Leu Cys Ile Pro Glu Glu Lys
        835                 840                 845             
Gln Leu Arg Cys Pro Arg Ala Ile Ala Ser Phe Phe Asp Asp Thr Met
    850                 855                 860                 
Lys Val Gln Arg Arg Arg Gly Thr His Lys Val Ser Gln Leu His Ile
865                 870                 875                 880 
Ser Gly Lys Ser Lys Leu Phe Met Ser Leu Gly Asn Leu Pro Gly Lys
                885                 890                 895     
Gly Asn
        


<210> 2564
<211> 188
<212> PRT
<213> Homo sapiens

<400> 2564
Met Gly Gly Ser Ser Pro Leu Gln Glu Gly Leu Val Gly Gly Val Ala
 1               5                  10                  15      
Glu Leu Ser Val Gln Gly Pro Ala Val Pro Lys Thr Thr Pro Gly Cys
            20                  25                  30          
Ala Gln Thr Pro Cys Gly Ala Gly Ser Pro Asp Thr Ala Leu Asp Pro
        35                  40                  45              
Gly Gly Ser Thr Ser Pro Gln Lys Leu Asp Ser Pro Ser Ala Gln Gly
    50                  55                  60                  
Thr Pro Asp Pro Ser Pro Leu Ala Asn Pro Arg His Leu Ala Gly Glu
65                  70                  75                  80  
His Val Lys Arg Gln Thr Ala Ala Trp Val Pro Thr Asn Arg Asp Ser
                85                  90                  95      
Thr Val Pro Ser Asp Pro Trp Asp Cys Lys Arg Arg Pro Trp Pro Leu
            100                 105                 110         
Leu Val Leu Arg Pro Leu Ala Pro Gly Thr Lys Ala Pro Pro Gly Gly
        115                 120                 125             
Gln Asn Gly Arg Gly Arg Gln Lys Gly Ser Pro Cys Ser Arg Arg Leu
    130                 135                 140                 
Leu Leu Glu Pro Ala Gly Pro Leu Gly Pro Ala Ser Val Arg Cys Ile
145                 150                 155                 160 
Arg Thr Thr Thr Pro Gln Ala Ser Gly Arg Thr Ser Gly Glu Asn Asp
                165                 170                 175     
Ile Thr Leu Glu Arg Ser Pro Phe Glu Leu Leu Ser
            180                 185             


<210> 2565
<211> 574
<212> PRT
<213> Homo sapiens

<400> 2565
Met Gly Pro Asp Ser Asp Ile Leu Glu Leu Val Gln Asp Val Ile Asn
 1               5                  10                  15      
Arg Val Thr Asp Val Phe Ala Lys His Trp Arg Ala Asp Pro His Leu
            20                  25                  30          
Thr Ser Val Thr Ser Lys Ala Pro Cys Gly Ser Leu Val Val Gly Leu
        35                  40                  45              
Ala Thr Pro Leu Arg Arg Glu Val His Leu Thr Ala Leu Pro Asn Cys
    50                  55                  60                  
Phe Phe Val Phe Pro Glu Glu Thr Gly Trp Gly Gly Lys Gly Asp Arg
65                  70                  75                  80  
Asp Ile Ser Pro Ser Leu Arg Ser Lys Arg Cys Ser Pro Pro Val Thr
                85                  90                  95      
Pro Lys Pro Met Tyr Pro Asp Gly Asn Ser Ile Val Lys Glu Thr Ser
            100                 105                 110         
Ile Phe Ile Gly Lys Glu Gly Leu Gly Gln Asp Glu Pro Pro Cys Pro
        115                 120                 125             
Val His Ser Gln Ser His Arg Pro Cys Leu Ser Ser His Leu Gly Lys
    130                 135                 140                 
Leu Met Tyr Ala Leu Leu Ala Arg Arg Leu Thr Ala Phe Val Ser Ile
145                 150                 155                 160 
Thr Ser Asn Ser Lys Phe Arg Pro Ser Thr Val Gly Pro Ser Asp Val
                165                 170                 175     
Asp Gln Trp Trp Ser Ala Arg Ile Tyr Arg Pro Gln Ala Gln Gln Val
            180                 185                 190         
Gln Cys Pro Met Ala Thr Phe Phe Gln Asp Ser Ser Ser Asn Pro Ser
        195                 200                 205             
Cys Arg Cys Leu His Ser Pro Glu Asn Leu Pro Asp Pro Gln Ser Pro
    210                 215                 220                 
Val Thr Ala Arg Pro Arg Lys Ser Trp Glu Asp Arg Val Pro Leu Ala
225                 230                 235                 240 
Glu Lys Glu Ser Ile Ile Leu Lys Ala Ala Pro Gly Val Ile Ala Lys
                245                 250                 255     
Ser Ser Phe Ser Glu Phe Met Leu Lys Pro Trp Lys Ala Ser Ala Thr
            260                 265                 270         
Met Ile Glu Gly Asp Met Glu Glu Ala Lys Pro Ser Trp Pro Ala Asn
        275                 280                 285             
Val Thr Ser His Asp Glu Pro Leu Ile Leu Met Gly Leu Leu Ile Arg
    290                 295                 300                 
Arg Phe Lys Ile Lys Arg Glu Ala Leu Thr Leu Leu Ala Leu Ala Met
305                 310                 315                 320 
Gly Glu Gly Lys Glu Ser Lys Pro Gly Leu Ile Arg Asp Pro Asp Gly
                325                 330                 335     
Cys Lys Lys Ser Ser Trp Gly Arg Phe Asn Pro Ser Leu Phe Gln Lys
            340                 345                 350         
Glu Gly Asp Arg Gly Met Pro Ile Leu Ser Gln Leu Gln Gly Thr Arg
        355                 360                 365             
Ala Phe Asn Lys His Cys Leu Arg Ala Ala Pro Ala Gly His Ser Ser
    370                 375                 380                 
Leu Glu Ser Pro Thr Asn Met Pro Ser Pro Ser Pro Asp Tyr Phe Thr
385                 390                 395                 400 
Trp Asn Leu Thr Trp Ile Met Lys Asp Ser Phe Pro Phe Leu Ser His
                405                 410                 415     
Arg Ser Arg Tyr Ala Arg Leu His Gln His Arg Glu Trp Glu Lys Gly
            420                 425                 430         
Cys Gln Gln Ser Trp Ser Ala Glu Cys Met Leu Ser Cys Ala Leu Asp
        435                 440                 445             
Met Ser Val Ile Lys Thr Asn Arg Thr His Leu Leu Pro Ser Arg Ser
    450                 455                 460                 
Ser Gly Gly Arg Gly Asn Leu Pro Leu Gly Met Thr Thr Ser Pro Cys
465                 470                 475                 480 
Leu Gly Ala Ala Ser Pro Glu Gln Arg Gln Ala Glu Trp Ser Val Gly
                485                 490                 495     
Leu Ile Val Ser Ala Gln Glu Arg Arg Arg Asn Arg Pro Leu Leu Ser
            500                 505                 510         
Val Val Leu Gln Met Arg Tyr Ser Asp Gly Arg Lys Thr Pro Arg Thr
        515                 520                 525             
Val Arg Gly Arg Pro Pro Gly Gly Ala Glu Gly Arg Phe Tyr Ser Leu
    530                 535                 540                 
Tyr Leu Ile Gly Thr Glu Leu Glu Glu Gly Glu Gly Glu Arg Phe Lys
545                 550                 555                 560 
Lys His Thr Arg Ser Arg Thr Ser Glu Glu Ala Gln Gly Lys
                565                 570                 


<210> 2566
<211> 576
<212> PRT
<213> Homo sapiens

<400> 2566
Met Arg Gln Thr Val Ala Thr Gly Val Ile Lys Ala Val Asp Lys Lys
 1               5                  10                  15      
Ala Ala Gly Val Gly Lys Leu Ser Glu Glu Ala Val Glu Asp Gly Leu
            20                  25                  30          
Phe His Glu Phe Lys Gly Phe Arg Asp Val Arg Val Lys Ile Asn Gln
        35                  40                  45              
Leu Ser Gly Ser Gly Ser Gly Asp Glu Leu Val Ala Phe Val Asn Phe
    50                  55                  60                  
Pro Gln Pro Glu Asp Ala Arg Thr Glu Ala Val His Gly Ser Arg His
65                  70                  75                  80  
His Ser Cys Ser Pro Leu Asp Lys Asp Ile Tyr Pro Pro Ser Ala Ser
                85                  90                  95      
Val Val Gly Ala Ser Val Gly Gly His Pro His Ser Pro Gly Gly Gly
            100                 105                 110         
Gly Gly Gln Arg Ser Leu Ser Ser Gly Gly Ala Ala Leu Gly Tyr Arg
        115                 120                 125             
Asp Arg Glu Leu Glu Arg Lys Gly Asp Tyr Leu Phe Tyr Glu Arg Val
    130                 135                 140                 
Pro Pro Ala Tyr Ser Leu Lys Pro Arg Glu Gly Ala Glu Ala Asp Ala
145                 150                 155                 160 
Ala Pro Phe Arg Lys Val Asp Glu Met Ser Pro Lys Asp His His Arg
                165                 170                 175     
Thr Asn Gln Met Leu Phe Leu Gly Asn Leu Asp Thr Thr Val Thr Glu
            180                 185                 190         
Ser Asp Ile Arg Arg Ala Phe Asp Cys Phe Gly Val Ile Thr Glu Val
        195                 200                 205             
Asp Ile Lys Ser Pro Phe Leu Gly Gln Ser Ser Asn Tyr Ser Leu Leu
    210                 215                 220                 
Lys Phe Glu Asn Leu Asp Met Ser His Arg Ala Lys Leu Ala Met Phe
225                 230                 235                 240 
Ser Lys Ile Ile Ile Trp Asn Pro Ile Lys Ile Gly Tyr Gly Lys Ala
                245                 250                 255     
Thr His Thr Thr His Leu Trp Asp Phe Pro Leu Gly Gly Pro Asp His
            260                 265                 270         
His Leu Arg Leu Asp Phe Ala Asp Thr Lys Arg Arg Tyr Gln Gln Gln
        275                 280                 285             
Tyr Met Gln Pro Leu Pro Leu Thr His Tyr Glu Leu Val Thr Asp Ala
    290                 295                 300                 
Phe Gly His Gln Ala Phe Asp Pro Leu Arg Asp Trp Val Pro Pro Pro
305                 310                 315                 320 
Pro Pro Ile Gly Glu Gly Ser Thr Gly Thr Ala Ala Thr Ala Val Pro
                325                 330                 335     
Ala Tyr Glu Pro Leu Asn Ser Leu Asp His Arg Arg Asp Ser Cys Trp
            340                 345                 350         
Ser Leu Asp Arg Asp Arg Gly Asp Gln Asp Leu Pro Ser Ser Arg Asp
        355                 360                 365             
Gln Pro Ala Glu Trp Ile Gly Ser Thr Thr Glu Gly Lys Asn Leu Leu
    370                 375                 380                 
Lys Lys Glu Asp His Thr Asp Gly Ser Gly Pro Ser Thr Asn Thr Ala
385                 390                 395                 400 
Ser Trp Lys Leu Lys Ser Pro Ser Gln Lys Gln Asp Glu Gly Thr Ala
                405                 410                 415     
Pro Val Ala Ala Ala Ser Pro Lys Leu Cys Leu Ala Trp Gln Gly Met
            420                 425                 430         
Leu Leu Leu Lys Asn Ser Asn Phe Pro Ser Asn Ile Pro Ile Cys Ser
        435                 440                 445             
Cys Cys Arg Val Thr Ser Lys Trp Leu Ala Val Phe Leu Trp Arg Ala
    450                 455                 460                 
Lys Val Ala Gln Leu Arg Ile Thr Gln Cys Leu Cys Leu Asp Gln Pro
465                 470                 475                 480 
Lys Leu Asp Glu Val Thr Arg Cys Ile Lys Val Ala Gly Pro Asn Gly
                485                 490                 495     
Tyr Ala Ile Leu Leu Ala Val Pro Gly Ser Ser Asp Ser Arg Ser Pro
            500                 505                 510         
Ser Ser Ser Asp Thr Val Thr Ser Thr Lys Arg Leu Leu Arg Ser Leu
        515                 520                 525             
Val Ser Tyr Leu Lys Gln Lys Gln Leu Ser His Gln Phe Leu Asp Ser
    530                 535                 540                 
Lys Ala Leu Ala Lys Ser Glu Glu Asp Tyr Leu Val Met Ile Ile Val
545                 550                 555                 560 
His Ala Lys Leu Val Glu Gln Gln Met Glu Met Trp Asn Ser Lys Leu
                565                 570                 575     


<210> 2567
<211> 125
<212> PRT
<213> Homo sapiens

<400> 2567
Met Gly Pro Gly Gly Pro Leu Leu Ser Pro Ser Arg Gly Phe Leu Leu
 1               5                  10                  15      
Cys Lys Thr Gly Trp His Ser Asn Arg Leu Leu Gly Asp Cys Gly Pro
            20                  25                  30          
His Thr Pro Val Ser Thr Ala Leu Ser Phe Ile Ala Val Gly Met Ala
        35                  40                  45              
Ala Pro Ser Met Lys Glu Arg Gln Val Cys Trp Gly Ala Arg Asp Glu
    50                  55                  60                  
Tyr Trp Lys Cys Leu Asp Glu Asn Leu Glu Asp Ala Ser Gln Cys Lys
65                  70                  75                  80  
Lys Leu Arg Ser Ser Phe Glu Ser Ser Cys Pro Gln Gln Trp Ile Lys
                85                  90                  95      
Tyr Phe Asp Lys Arg Arg Asp Tyr Leu Lys Phe Lys Glu Lys Phe Glu
            100                 105                 110         
Ala Gly Gln Phe Glu Pro Ser Glu Thr Thr Ala Lys Ser
        115                 120                 125 


<210> 2568
<211> 184
<212> PRT
<213> Homo sapiens

<400> 2568
Met Ser Leu Val Ser Leu Glu Ala Glu Met Pro Glu Arg Thr Leu Lys
 1               5                  10                  15      
Glu Gln Asp Leu Thr Ser Ala Phe Val Ala Glu Trp Cys Asp Gln Trp
            20                  25                  30          
Gly Gln Met Pro Arg Ser Leu Leu Ser Pro Tyr Ile Ile Ile Val Cys
        35                  40                  45              
Gly Ser Pro Gly Ile Ala Lys Gln Ala Ser His Val Ala Val Ile Gly
    50                  55                  60                  
Leu Leu Arg Asp Leu Ala Glu Ser Glu Pro Pro Leu Pro Gln Ile Tyr
65                  70                  75                  80  
Thr Val Ile Ser Met Val Asn Gln Glu Gln Gly Gly Glu Asp Ser Arg
                85                  90                  95      
Ser Ile Gln Ser Gln Ile Leu Pro Val Gly Ser Glu Ser Glu His Leu
            100                 105                 110         
Glu Glu Ala Ser Leu Arg Ser Arg Glu Gly Phe Val Asp Leu Ile Ser
        115                 120                 125             
Leu Val Phe Arg Lys Ser Trp Gly Lys Met Leu His Pro Arg Val Pro
    130                 135                 140                 
Ala Glu Thr Val Cys Gly Glu Lys Arg Leu Ala Glu Val Thr Gly Cys
145                 150                 155                 160 
Leu Cys Ser Lys Cys Arg Gln Leu Arg Ser Thr Ser Asp Ser Ala Glu
                165                 170                 175     
Gly Leu Arg Asp Lys Ser Gly Lys
            180                 


<210> 2569
<211> 396
<212> PRT
<213> Homo sapiens

<400> 2569
Met Thr Thr Thr Thr Thr Phe Lys Gly Val Asn Pro Asn Ser Arg Asn
 1               5                  10                  15      
Ser Ser Arg Val Leu Arg Leu Leu Gly Gly Gly Ser Asn Phe Ser Leu
            20                  25                  30          
Gly Phe Asp Glu Pro Thr Glu Gln Pro Val Arg Lys Asn Lys Met Ser
        35                  40                  45              
Ser Ser Ile Phe Gly Thr Pro Glu Glu Asn Pro Pro Ser Trp Ala Thr
    50                  55                  60                  
Leu Ala Glu Asn Thr Asn Lys Asn Lys Asn Gln Phe Leu Pro Ser Trp
65                  70                  75                  80  
Trp Gly Gln Met Val Lys Pro Ala Ser Thr Leu Arg Ile Thr Ser Thr
                85                  90                  95      
Met Arg Glu Ala Glu Pro Lys Arg Tyr Val Gly Thr Lys Glu Gly Arg
            100                 105                 110         
Arg Arg Ser Gln Asp Gln Pro Leu Met Gly Ala Ala Ser Arg Glu Glu
        115                 120                 125             
Cys Gly Leu Gly Gln Gly Arg Gly Phe Asp Ser Thr Val Ser Ser Trp
    130                 135                 140                 
Asp Gly Glu Lys Phe Ser Val Gly Thr Glu Ser Phe Ser Arg Pro Glu
145                 150                 155                 160 
Gly Leu Glu Arg Lys Arg Ile Arg Glu Ala Lys Gly Leu Leu Val Ala
                165                 170                 175     
Gln Lys Gly Ser Ser Met Ala Gly Ala Lys Asp Asp Leu Trp Glu Thr
            180                 185                 190         
Val Gly Gly Asn Glu Val Arg Glu Ile Asn Val Val Val Met Pro Arg
        195                 200                 205             
Met Glu Pro Asn Val Glu Thr Glu Ser Arg Lys Ser Gly Glu Asn Pro
    210                 215                 220                 
Leu Thr Val Thr Gln Ile Gly Ser Asp Glu Ser Pro Glu Ala Ala Leu
225                 230                 235                 240 
Gly Lys Glu Arg Lys Glu Gln Ala Val Gly Glu Phe Pro Glu Val Glu
                245                 250                 255     
Gly Gly Lys Glu Lys Glu Thr Gly Gly Met Ser Ser Val Tyr Glu His
            260                 265                 270         
Val Gln Gly Met Gly Ala Arg Glu Gly Phe Thr Ser Pro Gly Lys Ala
        275                 280                 285             
Gln Gly Thr Gln Ser Glu Ser Ser Arg Ala Gln Gln Cys Pro Glu Leu
    290                 295                 300                 
Thr Asp Gly Ile Arg Lys Ser Ser Ser Ser Gln Pro Gln Ala Val Phe
305                 310                 315                 320 
Lys Ile Gly Val Val Ala Pro Pro Ala Lys Ala Thr Leu Pro Thr Asp
                325                 330                 335     
Leu Val Thr Asn Leu Gly Asp Gln Arg Thr Leu Ile Ser Lys Gly Leu
            340                 345                 350         
Asp Pro Val Lys Gln Arg Ser Val Ala Thr Asp Arg Phe Pro Glu Ser
        355                 360                 365             
Glu Leu Pro Leu Leu Glu Ser Lys Ala Arg Arg Asn Pro Val Trp Thr
    370                 375                 380                 
Tyr Phe Ile Pro Gln Asp Arg Ala Ala Leu Ile Glu
385                 390                 395     


<210> 2570
<211> 104
<212> PRT
<213> Homo sapiens

<400> 2570
Met Lys Pro Pro Asp Asn Phe Ile Glu Ala Gly Leu Glu Ser Ile Phe
 1               5                  10                  15      
Thr Tyr Trp His Arg Asp Ala Glu Ala Ala Ala Tyr Ser Ser Arg Arg
            20                  25                  30          
Leu Glu Glu Gln Trp Pro Trp Gly Pro Ala Ser Leu Arg Glu Gln Glu
        35                  40                  45              
Arg Leu Lys Glu Arg Arg Pro Arg Gln Ala Leu Arg Leu Ser Gln Lys
    50                  55                  60                  
Cys Gln Asn Ser Phe Ala Leu Gln Gln Cys Gly Asn Val Cys Pro Arg
65                  70                  75                  80  
Thr Pro Leu Lys Leu Leu Cys Arg Met Ser Val Glu Ser Thr Gly His
                85                  90                  95      
Ser Pro Met Asp Ser Leu Glu Met
            100                 


<210> 2571
<211> 268
<212> PRT
<213> Homo sapiens

<400> 2571
Met Val Tyr Met Phe Glu Tyr Asp Ser Thr His Gly Lys Phe His Gly
 1               5                  10                  15      
Thr Val Lys Ala Glu Lys Gly Lys Leu Val Ile Asn Gly Asn Pro Ile
            20                  25                  30          
Thr Ile Phe Gln Glu Gln Asp Pro Ser Lys Ile Lys Trp Gly Asp Ala
        35                  40                  45              
Gly Ala Glu Tyr Val Val Lys Ser Thr Ser Gly Gly Ala Thr Arg Val
    50                  55                  60                  
Ile Ile Ser Ala Pro Ser Ala Asp Ala Pro Met Phe Val Met Gly Met
65                  70                  75                  80  
Asn His Lys Lys Tyr Asp Asn Arg Leu Asn Ile Val Ser Tyr Ala Ser
                85                  90                  95      
Cys Thr Thr Asn Cys Leu Val Pro Leu Gly Glu Val Ile His Asp Asn
            100                 105                 110         
Phe Gly Ile Val Glu Arg Phe Gln Asn Thr Val His Ala Ile Thr Ala
        115                 120                 125             
Thr Gln Lys Ile Val Asp Gly Leu Ser Gly Lys Leu Trp Cys Asp Gly
    130                 135                 140                 
Cys Gly Ala Leu Gln Asn Ile Thr Pro Ala Ser Thr Gly Thr Ala Lys
145                 150                 155                 160 
Ala Val Gly Val Ile Ser Lys Leu Asn Lys Lys Leu Thr Asp Met Gly
                165                 170                 175     
Phe Cys Val His Ile Thr Asn Val Ser Val Met Asp Leu Thr Cys Arg
            180                 185                 190         
Leu Glu Lys Pro Ala Lys Tyr Asp Asp Ile Lys Lys Gly Ile Trp Gly
        195                 200                 205             
Asp Thr Glu His Gln Val Val Ser Ser Asp Phe Asn Arg Asp Thr His
    210                 215                 220                 
Ser Ser Thr Phe Asp Ala Gly Ala Gly Ile Ala Leu Lys Asp His Phe
225                 230                 235                 240 
Val Lys Leu Ile Ser Trp Tyr Asp Asn Glu Phe Gly Tyr Ser Asn Arg
                245                 250                 255     
Val Val Asp Leu Met Ala His Ile Ala Ser Lys Glu
            260                 265             


<210> 2572
<211> 260
<212> PRT
<213> Homo sapiens

<400> 2572
Met Asn Asn Leu Asn Asp Pro Pro Asn Trp Asn Ile Arg Pro Asn Ser
 1               5                  10                  15      
Arg Ala Asp Gly Gly Asp Gly Ser Arg Trp Asn Tyr Ala Leu Leu Val
            20                  25                  30          
Pro Met Leu Gly Leu Ala Ala Phe Arg Trp Ile Trp Ser Arg Glu Ser
        35                  40                  45              
Gln Lys Glu Val Glu Lys Glu Arg Glu Ala Tyr Arg Arg Arg Thr Ala
    50                  55                  60                  
Ala Phe Gln Gln Asp Leu Glu Ala Lys Tyr His Ala Met Ile Ser Glu
65                  70                  75                  80  
Asn Arg Arg Ala Val Ala Gln Leu Ser Leu Glu Leu Glu Lys Glu Gln
                85                  90                  95      
Asn Arg Thr Ala Ser Tyr Arg Glu Ala Leu Ile Ser Gln Gly Arg Lys
            100                 105                 110         
Leu Val Glu Glu Lys Lys Leu Leu Glu Gln Glu Arg Ala Gln Val Met
        115                 120                 125             
Gln Glu Lys Arg Gln Val Gln Pro Leu Arg Ser Ala Tyr Leu Ser Cys
    130                 135                 140                 
Leu Gln Arg Glu Glu Asn Trp Gln Arg Arg Ala Arg Leu Leu Leu Lys
145                 150                 155                 160 
Glu Phe Glu Ala Val Leu Thr Glu Arg Gln Asn Ile Tyr Cys Ser Leu
                165                 170                 175     
Phe Leu Pro Arg Ser Lys Arg Leu Glu Ile Glu Lys Ser Leu Leu Val
            180                 185                 190         
Arg Ala Ser Val Asp Pro Val Ala Ala Asp Leu Glu Met Ala Ala Gly
        195                 200                 205             
Leu Thr Asp Ile Phe Gln His Asp Thr Tyr Cys Gly Asp Val Trp Asn
    210                 215                 220                 
Thr Asn Lys Arg Gln Asn Gly Arg Leu Met Trp Leu Tyr Leu Lys Tyr
225                 230                 235                 240 
Trp Glu Leu Val Val Glu Leu Lys Lys Phe Lys Arg Val Glu Glu Ala
                245                 250                 255     
Ile Leu Glu Lys
            260 


<210> 2573
<211> 118
<212> PRT
<213> Homo sapiens

<400> 2573
Met Lys Pro Val Gln Ala Ala Pro Thr Pro Ala Val Arg Arg Lys Glu
 1               5                  10                  15      
Ser Ser Gly Gly Pro Gly Ala His Gly Gly Pro Ser Leu Arg Gln Ser
            20                  25                  30          
Ser Pro Gly Arg Ala Arg Ser Pro Ala Ala Ala Glu Phe Arg Gln Arg
        35                  40                  45              
Pro Arg Thr Ala Arg Arg Ala Ser Pro Gly Pro Arg Arg Lys Ala Gly
    50                  55                  60                  
Arg Arg Gly Ser Thr Tyr Ser Asp Thr Ile Leu Ala Arg Ser Ser Ser
65                  70                  75                  80  
His Thr His Ser Phe Leu Gly Glu Arg Pro Arg Arg Arg Ala Val Val
                85                  90                  95      
Asn Thr His Ser Ser Ala Ala Leu Tyr Ser His Ala Arg Gln Pro Thr
            100                 105                 110         
Tyr Ala Leu Pro Pro Glu
        115             


<210> 2574
<211> 1259
<212> PRT
<213> Homo sapiens

<400> 2574
Met Ala Asn Gly Val Ile Pro Pro Pro Gly Gly Ala Ser Pro Leu Pro
 1               5                  10                  15      
Gln Val Arg Val Pro Leu Glu Glu Pro Pro Leu Ser Pro Asp Val Glu
            20                  25                  30          
Glu Glu Asp Asp Asp Leu Gly Lys Thr Leu Ala Val Ser Arg Phe Gly
        35                  40                  45              
Asp Leu Ile Ser Lys Pro Pro Ala Trp Asp Pro Glu Lys Pro Ser Arg
    50                  55                  60                  
Ser Tyr Ser Glu Arg Asp Phe Glu Phe His Arg His Thr Ser His His
65                  70                  75                  80  
Thr His His Pro Leu Ser Ala Arg Leu Pro Pro Pro His Lys Leu Arg
                85                  90                  95      
Arg Leu Pro Pro Thr Ser Ala Arg His Thr Arg Arg Lys Arg Lys Lys
            100                 105                 110         
Glu Lys Thr Ser Ala Pro Pro Ser Glu Gly Thr Pro Pro Ile Gln Glu
        115                 120                 125             
Glu Gly Gly Ala Gly Val Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu
    130                 135                 140                 
Glu Gly Glu Ser Glu Ala Glu Pro Val Glu Pro Pro His Ser Gly Thr
145                 150                 155                 160 
Pro Gln Lys Ala Lys Phe Ser Ile Gly Ser Asp Glu Asp Asp Ser Pro
                165                 170                 175     
Gly Leu Pro Gly Arg Ala Ala Val Thr Lys Pro Leu Pro Ser Val Gly
            180                 185                 190         
Pro His Thr Asp Lys Ser Pro Gln His Ser Ser Arg Pro Cys Ser Glu
        195                 200                 205             
Leu Arg Asp Gly Asp Gly Thr Thr Asp Leu Ala Leu Ser Ser Pro Arg
    210                 215                 220                 
Leu Leu Cys Cys Leu Pro Ser Ser Pro Ser Pro Arg Ala Arg Ala Ser
225                 230                 235                 240 
Arg Leu Ala Gly Glu Lys Ser Arg Pro Trp Ser Pro Ser Ala Ser Tyr
                245                 250                 255     
Asp Leu Arg Glu Arg Leu Cys Pro Gly Ser Ala Leu Gly Asn Pro Gly
            260                 265                 270         
Gly Pro Glu Gln Gln Val Pro Thr Asp Glu Ala Glu Ala Gln Met Leu
        275                 280                 285             
Gly Ser Ala Asp Leu Asp Asp Met Lys Ser His Arg Leu Glu Asp Asn
    290                 295                 300                 
Pro Gly Val Arg Arg His Leu Val Lys Lys Pro Ser Arg Thr Gln Gly
305                 310                 315                 320 
Gly Arg Gly Ser Pro Ser Gly Leu Ala Pro Ile Leu Arg Arg Lys Lys
                325                 330                 335     
Lys Lys Lys Lys Leu Asp Arg Arg Pro His Glu Val Phe Val Glu Leu
            340                 345                 350         
Asn Glu Leu Met Leu Asp Arg Ser Gln Glu Pro His Trp Arg Glu Thr
        355                 360                 365             
Ala Arg Trp Ile Lys Phe Glu Glu Asp Val Glu Glu Glu Thr Glu Arg
    370                 375                 380                 
Trp Gly Lys Pro His Val Ala Ser Leu Ser Phe Arg Ser Leu Leu Glu
385                 390                 395                 400 
Leu Arg Arg Thr Ile Ala His Gly Ala Ala Leu Leu Asp Leu Glu Gln
                405                 410                 415     
Thr Thr Leu Pro Gly Ile Ala His Leu Val Val Glu Thr Met Ile Val
            420                 425                 430         
Ser Asp Gln Ile Arg Pro Glu Asp Arg Ala Ser Val Leu Arg Thr Leu
        435                 440                 445             
Leu Leu Lys His Ser His Pro Asn Asp Asp Lys Asp Ser Gly Phe Phe
    450                 455                 460                 
Pro Arg Asn Pro Ser Ser Ser Ser Met Asn Ser Val Leu Gly Asn His
465                 470                 475                 480 
His Pro Thr Pro Ser His Gly Pro Asp Gly Ala Val Pro Thr Met Ala
                485                 490                 495     
Asp Asp Leu Gly Glu Pro Ala Pro Leu Trp Pro His Asp Pro Asp Ala
            500                 505                 510         
Lys Glu Lys Pro Leu His Met Pro Gly Gly Asp Gly His Arg Gly Lys
        515                 520                 525             
Ser Leu Lys Leu Leu Glu Lys Ile Pro Glu Asp Ala Glu Ala Thr Val
    530                 535                 540                 
Val Leu Val Gly Cys Val Pro Phe Leu Glu Gln Pro Ala Ala Ala Phe
545                 550                 555                 560 
Val Arg Leu Asn Glu Ala Val Leu Leu Glu Ser Val Leu Glu Val Pro
                565                 570                 575     
Val Pro Val Arg Phe Leu Phe Val Met Leu Gly Pro Ser His Thr Ser
            580                 585                 590         
Thr Asp Tyr His Glu Leu Gly Arg Ser Ile Ala Thr Leu Met Ser Asp
        595                 600                 605             
Lys Leu Phe His Glu Ala Ala Tyr Gln Ala Asp Asp Arg Gln Asp Leu
    610                 615                 620                 
Leu Ser Ala Ile Ser Glu Phe Leu Asp Gly Ser Ile Val Ile Pro Pro
625                 630                 635                 640 
Ser Glu Val Glu Gly Arg Asp Leu Leu Arg Ser Val Ala Ala Phe Gln
                645                 650                 655     
Arg Glu Leu Leu Arg Lys Arg Arg Glu Arg Glu Gln Thr Lys Val Glu
            660                 665                 670         
Met Thr Thr Arg Gly Gly Tyr Thr Ala Pro Gly Lys Glu Leu Ser Leu
        675                 680                 685             
Glu Leu Gly Gly Ser Glu Ala Thr Pro Glu Asp Asp Pro Leu Leu Arg
    690                 695                 700                 
Thr Gly Ser Val Phe Gly Gly Leu Val Arg Asp Val Arg Arg Arg Tyr
705                 710                 715                 720 
Pro His Tyr Pro Ser Asp Leu Arg Asp Ala Leu His Ser Gln Cys Val
                725                 730                 735     
Ala Ala Val Leu Phe Ile Tyr Phe Ala Ala Leu Ser Pro Ala Ile Thr
            740                 745                 750         
Phe Gly Gly Leu Leu Gly Glu Lys Thr Glu Gly Leu Met Gly Val Ser
        755                 760                 765             
Glu Leu Ile Val Ser Thr Ala Val Leu Gly Val Leu Phe Ser Leu Leu
    770                 775                 780                 
Gly Ala Gln Pro Leu Leu Val Val Gly Phe Ser Gly Pro Leu Leu Val
785                 790                 795                 800 
Phe Glu Glu Ala Phe Phe Lys Phe Cys Arg Ala Gln Asp Leu Glu Tyr
                805                 810                 815     
Leu Thr Gly Arg Val Trp Val Gly Leu Trp Leu Val Val Phe Val Leu
            820                 825                 830         
Ala Leu Val Ala Ala Glu Gly Ser Phe Leu Val Arg Tyr Ile Ser Pro
        835                 840                 845             
Phe Thr Gln Glu Ile Phe Ala Phe Leu Ile Ser Leu Ile Phe Ile Tyr
    850                 855                 860                 
Glu Thr Phe Tyr Lys Leu Tyr Lys Val Phe Thr Glu His Pro Leu Leu
865                 870                 875                 880 
Pro Phe Tyr Pro Pro Glu Gly Ala Leu Glu Gly Ser Leu Asp Ala Gly
                885                 890                 895     
Leu Glu Pro Asn Gly Ser Ala Leu Pro Pro Thr Glu Gly Pro Pro Ser
            900                 905                 910         
Pro Arg Asn Gln Pro Asn Thr Ala Leu Leu Ser Leu Ile Leu Met Leu
        915                 920                 925             
Gly Thr Phe Phe Ile Ala Phe Phe Leu Arg Lys Phe Arg Asn Ser Arg
    930                 935                 940                 
Phe Leu Gly Gly Lys Ala Arg Arg Ile Ile Gly Asp Phe Gly Ile Pro
945                 950                 955                 960 
Ile Ser Ile Leu Val Met Val Leu Val Asp Tyr Ser Ile Thr Asp Thr
                965                 970                 975     
Tyr Thr Gln Lys Leu Thr Val Pro Thr Gly Leu Ser Val Thr Ser Pro
            980                 985                 990         
Asp Lys Arg Ser Trp Phe Ile Pro Pro Leu Gly Ser Ala Arg Pro Phe
        995                 1000                1005            
Pro Pro Trp Met Met Val Ala Ala Ala Val Pro Ala Leu Leu Val Leu
    1010                1015                1020                
Ile Leu Ile Phe Met Glu Thr Gln Ile Thr Ala Leu Ile Val Ser Gln
1025                1030                1035                1040
Lys Ala Arg Arg Leu Leu Lys Gly Ser Gly Phe His Leu Asp Leu Leu
                1045                1050                1055    
Leu Ile Gly Ser Leu Gly Gly Leu Cys Gly Leu Phe Gly Leu Pro Trp
            1060                1065                1070        
Leu Thr Ala Ala Thr Val Arg Ser Val Thr His Val Asn Ala Leu Thr
        1075                1080                1085            
Val Met Arg Thr Ala Ile Ala Pro Gly Asp Lys Pro Gln Ile Gln Glu
    1090                1095                1100                
Val Arg Glu Gln Arg Val Thr Gly Val Leu Ile Ala Ser Leu Val Gly
1105                1110                1115                1120
Leu Ser Ile Val Met Gly Ala Val Leu Arg Arg Ile Pro Leu Ala Val
                1125                1130                1135    
Leu Phe Gly Ile Phe Leu Tyr Met Gly Val Thr Ser Leu Ser Gly Ile
            1140                1145                1150        
Gln Leu Ser Gln Arg Leu Leu Leu Ile Leu Met Pro Ala Lys His His
        1155                1160                1165            
Pro Glu Gln Pro Tyr Val Thr Lys Val Lys Thr Trp Arg Met His Leu
    1170                1175                1180                
Phe Thr Cys Ile Gln Leu Gly Cys Ile Ala Leu Leu Trp Val Val Lys
1185                1190                1195                1200
Ser Thr Ala Ala Ser Leu Ala Phe Pro Phe Leu Leu Leu Leu Thr Val
                1205                1210                1215    
Pro Leu Arg His Cys Leu Leu Pro Arg Leu Phe Gln Asp Arg Glu Leu
            1220                1225                1230        
Gln Ala Leu Asp Ser Glu Asp Ala Glu Pro Asn Phe Asp Glu Asp Gly
        1235                1240                1245            
Gln Asp Glu Tyr Asn Glu Leu His Met Pro Val
    1250                1255                


<210> 2575
<211> 524
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 197, 208
<223> Xaa = Any Amino Acid

<400> 2575
Met Ala Glu His Ala Pro Arg Arg Cys Cys Leu Gly Trp Asp Phe Ser
 1               5                  10                  15      
Thr Gln Gln Val Lys Val Val Ala Val Asp Ala Glu Leu Asn Val Phe
            20                  25                  30          
Tyr Glu Glu Ser Val His Phe Asp Arg Asp Leu Pro Glu Phe Gly Thr
        35                  40                  45              
Gln Gly Gly Val His Val His Lys Asp Gly Leu Thr Val Thr Ser Pro
    50                  55                  60                  
Val Leu Met Trp Val Gln Ala Leu Asp Ile Ile Leu Glu Lys Met Lys
65                  70                  75                  80  
Ala Ser Gly Phe Asp Phe Ser Gln Val Leu Ala Leu Ser Gly Ala Gly
                85                  90                  95      
Gln Gln His Gly Ser Ile Tyr Trp Lys Ala Gly Ala Gln Gln Ala Leu
            100                 105                 110         
Thr Ser Leu Ser Pro Asp Leu Arg Leu His Gln Gln Leu Gln Asp Cys
        115                 120                 125             
Phe Ser Ile Ser Asp Cys Pro Val Trp Met Glu Ser Ser Thr Thr Ala
    130                 135                 140                 
Gln Cys Arg Gln Leu Glu Ala Ala Val Gly Gly Ala Gln Ala Leu Ser
145                 150                 155                 160 
Cys Leu Thr Gly Ser Arg Ala Tyr Glu Arg Phe Thr Gly Asn Gln Ile
                165                 170                 175     
Ala Lys Ile Tyr Gln Gln Asn Pro Glu Ala Tyr Ser His Thr Glu Arg
            180                 185                 190         
Ile Ser Leu Val Xaa Ser Phe Ala Ala Ser Leu Phe Leu Gly Ser Xaa
        195                 200                 205             
Ser Pro Ile Asp Tyr Ser Asp Gly Ser Gly Met Asn Leu Leu Gln Ile
    210                 215                 220                 
Gln Asp Lys Val Trp Ser Gln Ala Cys Leu Gly Ala Cys Ala Pro His
225                 230                 235                 240 
Leu Glu Glu Lys Leu Ser Pro Pro Val Pro Ser Cys Ser Val Val Gly
                245                 250                 255     
Ala Ile Ser Ser Tyr Asn Val Gln Arg Tyr Gly Phe Pro Pro Gly Cys
            260                 265                 270         
Lys Val Val Ala Phe Thr Gly Asp Asn Pro Ala Ser Leu Ala Gly Met
        275                 280                 285             
Arg Leu Glu Glu Gly Asp Ile Ala Val Ser Leu Gly Thr Ser Asp Thr
    290                 295                 300                 
Leu Phe Leu Trp Leu Gln Glu Pro Met Pro Ala Leu Glu Gly His Ile
305                 310                 315                 320 
Phe Cys Asn Pro Val Asp Ser Gln His Tyr Met Ala Leu Leu Cys Phe
                325                 330                 335     
Lys Asn Gly Ser Leu Met Arg Glu Lys Ile Arg Asn Glu Ser Val Ser
            340                 345                 350         
Arg Ser Trp Ser Asp Phe Ser Lys Ala Leu Gln Ser Thr Glu Met Gly
        355                 360                 365             
Asn Gly Gly Asn Leu Gly Phe Tyr Phe Asp Val Met Glu Ile Thr Pro
    370                 375                 380                 
Glu Ile Ile Gly Arg His Arg Phe Asn Thr Glu Asn His Lys Val Ala
385                 390                 395                 400 
Ala Phe Pro Gly Asp Val Glu Val Arg Ala Leu Ile Glu Gly Gln Phe
                405                 410                 415     
Met Ala Lys Arg Ile His Ala Glu Gly Leu Gly Tyr Arg Val Met Ser
            420                 425                 430         
Lys Thr Lys Ile Leu Ala Thr Gly Gly Ala Ser His Asn Arg Glu Ile
        435                 440                 445             
Leu Gln Val Leu Ala Asp Val Phe Asp Ala Pro Val Tyr Val Ile Asp
    450                 455                 460                 
Thr Ala Asn Ser Ala Cys Val Gly Ser Ala Tyr Arg Ala Phe His Gly
465                 470                 475                 480 
Leu Ala Gly Gly Thr Asp Val Pro Phe Ser Glu Val Val Lys Leu Ala
                485                 490                 495     
Pro Asn Pro Arg Leu Ala Ala Thr Pro Ser Pro Gly Ala Ser Gln Val
            500                 505                 510         
Arg Asp His Gln Asn Leu Phe Val Ala Phe Ala Leu
        515                 520                 


<210> 2576
<211> 1090
<212> PRT
<213> Homo sapiens

<400> 2576
Met Ile Glu Tyr Ala Asn Phe Ile Lys Gly Ser Asp Ile Phe Ile Thr
 1               5                  10                  15      
Asn Gln Met Asp Phe Lys Pro His Ser Leu Ala Ser Thr Lys Phe Pro
            20                  25                  30          
Thr Ala Asp Asn Ser Thr Asn Asn Glu Phe Asp Ser Pro Ser Ser Val
        35                  40                  45              
Asn Arg Glu Thr Thr Asn Ile Pro Lys Thr Glu Thr Asp Glu Thr Tyr
    50                  55                  60                  
Ser Glu Leu Gln Arg Ile Ile Lys Ala Phe Ser Pro Thr Arg Ile Ser
65                  70                  75                  80  
Gln His Arg Ile Tyr Lys Glu Arg Lys Ile Thr Asn Pro Ser Asp Gln
                85                  90                  95      
Asp Asp Pro Ala Ala Lys Phe Asp Ile Ser His Ile Thr Asn Thr Thr
            100                 105                 110         
Asp Leu Ser Leu Ala Met Glu Lys Pro Leu Pro Ser Val Thr Glu Leu
        115                 120                 125             
Asn Ser Leu Ser Thr Ser Asp Asn Asn Val Lys Lys Lys Val Tyr Ile
    130                 135                 140                 
Ser Glu Ala Glu Val Ser Arg Ser Asn Asp Gln Ser Ser Ser Pro Glu
145                 150                 155                 160 
Val Thr Thr Lys Glu Gly Thr Ile Ile Asp Thr Pro Thr Gly Thr Tyr
                165                 170                 175     
Gly Leu Pro Trp Lys Ser Thr Leu Leu Pro Ser Asn Phe Thr Thr Leu
            180                 185                 190         
Thr Ser Ser Ser Lys Asp Cys Glu Phe Asn Pro Val Ile Lys Met Lys
        195                 200                 205             
Lys Asp Thr Thr Thr Thr Asn Asn Asn Ile Thr Pro Gly Glu Arg Asn
    210                 215                 220                 
Ser Ser Ser Asp Lys Phe Lys Leu Ser Pro Ala Thr Ile Ile Ser Thr
225                 230                 235                 240 
Lys Gly Met Lys Asn Ile Ile Tyr Asn Ser Arg Tyr Gly Asp Lys Thr
                245                 250                 255     
Phe Ile Glu Lys Asp Ile Ser Ile Glu Val Val Pro Phe Ile Glu Asn
            260                 265                 270         
Ile Ser Lys Glu Thr Asn Asp Thr Pro Leu Ala Asp Gly Asn Ile Pro
        275                 280                 285             
Asn Asn Glu Asn Met Ile Thr Ile Met Pro Val Asp Ser Ala Leu Glu
    290                 295                 300                 
Tyr Asp Glu Asp Asn Asp Val Phe Ala Pro Val Glu Lys Arg Ser Val
305                 310                 315                 320 
Leu Leu Ile Glu Glu Thr Ile Val Thr Asn Asn Ser Asn Ala Leu Glu
                325                 330                 335     
Ser His Glu Phe Tyr Ala Gly Ala Ala Ala Ser Glu Thr Phe Ser Gln
            340                 345                 350         
Gly Thr Pro Ile Asp Ile Ser Thr Arg Lys Lys His Gln Ile Leu Ile
        355                 360                 365             
Phe Lys Glu Glu Asn Pro Asn Asn Asp Ile Thr Val Leu Lys Gly Ser
    370                 375                 380                 
Thr Ala Asn Phe Asn Thr Lys Thr Pro Ser Val Ala Pro Asn Val Ala
385                 390                 395                 400 
Lys Ala Thr Ile Ser Ala Arg Phe Asp Pro Asn Lys Leu Lys Thr Asn
                405                 410                 415     
Leu Ala Asp Ala Leu His Ser Gln Ser Ser Ile Ile Pro Leu Ile Glu
            420                 425                 430         
Val Asn Val Ile Pro Asp Asp Asn Leu Ser Phe Ile Ser Lys Asp Thr
        435                 440                 445             
Lys Glu Ala Asn Asn Arg Ala Ser Ile Ile Phe Thr Ser Met Asn Glu
    450                 455                 460                 
Pro Thr Ser Thr Val Val Asp Ser Thr Val Pro Ser Thr Glu Gly Ser
465                 470                 475                 480 
Tyr Val Ser Gly Asp Phe Met Leu Pro Gly Glu Asp Asn Val Lys Ser
                485                 490                 495     
Arg Gly Phe Gln Ser Leu Leu Arg Thr Asn Met Leu Leu Leu Asp Ser
            500                 505                 510         
Leu Asn Glu Asn Pro Glu Thr Pro Gly Leu Met Arg Asp Asn Ser Phe
        515                 520                 525             
Ser Glu Ser Ser Ile Thr Arg Ser Glu Glu Leu Glu Arg Ala Thr Glu
    530                 535                 540                 
Tyr Val Gly Ala Ile Asn Gly Gly Asn Val Pro Glu Lys Gln Val Ile
545                 550                 555                 560 
Ile Thr Gln Thr Asn Ile His Ser Tyr Pro Leu Ala Trp Gln Val Ser
                565                 570                 575     
Pro Ile Glu Ser Thr Phe Ser Asn Asn Pro Thr Asp Ser Glu Ile Asn
            580                 585                 590         
Phe Ser Phe Ser Val Asn Gly Asn Thr Pro Gly Asn Tyr Glu Thr Glu
        595                 600                 605             
Thr Asp Glu Ile Tyr Ser Lys Ser Gln Arg Ala Ile Glu Lys Ala Phe
    610                 615                 620                 
Ser Gln Ile Lys Glu Ser Gln Asn Ser Val Tyr Lys Ile Arg Lys Ile
625                 630                 635                 640 
Ala Asn Leu Ser Asp Gln Glu Asp Pro Ala Thr Met Phe Lys Leu Ser
                645                 650                 655     
His Phe Thr Asn Thr Thr Val Leu Ile Pro Ala Ile Trp Lys Ile Pro
            660                 665                 670         
Pro Ser Ala Thr Lys Leu Asn Leu Leu Ser Asn Ser Asp Ser Asp Val
        675                 680                 685             
Asp Glu Glu Phe His Met Ser Glu Ala Gly Asn Ser Phe Ser Glu Asp
    690                 695                 700                 
Thr Ser Lys Leu Lys Asp Asp Ser Phe Thr Val Lys Phe Asp Asp Thr
705                 710                 715                 720 
Ser Phe Lys Ser Gln Ala Pro Pro Asn Leu Lys Gly Ile Ser Ser Val
                725                 730                 735     
Tyr Ser Thr Ser Thr Leu Ser Glu Ala Ser Arg Pro Asn Asp Gln Ser
            740                 745                 750         
Ser Ala Phe His Ile Arg Val Ser Asn Thr Gly Arg Ser Ser Thr Asn
        755                 760                 765             
Thr Pro Ala Arg Leu His Gly Leu Gln Trp Arg Pro Thr Leu Pro Ser
    770                 775                 780                 
Asp Phe Thr Thr Ser Met Asp Ala Pro Ile Tyr Tyr Glu Leu Thr Pro
785                 790                 795                 800 
Val Thr Ile Met Gly Lys Asp Ile Thr Lys Lys Ile Asp Tyr Ser Phe
                805                 810                 815     
Leu Pro Glu Glu Thr Ile Ile Pro Ser Asp Gln Val Ile Ile Leu Pro
            820                 825                 830         
Ile Thr Ile Thr Ser Glu Asn Ser Met Ala Ser Thr Phe Lys Glu Asn
        835                 840                 845             
Ile Phe Lys His Lys Asp Phe Ile Asp Ser Glu Gln Ala Ala Glu Tyr
    850                 855                 860                 
Glu Lys Asn Tyr Phe Ile Lys Asp Ile Ser Glu Arg Met Asp Asp Ile
865                 870                 875                 880 
Ser Ser Glu Gly Lys Ile Thr Pro Ala Tyr Val Asp Asp Ile Ile Thr
                885                 890                 895     
Thr Ser Asp Asp Ser Gly Ser Glu Tyr Val Ser Asp Asn Ser Val Leu
            900                 905                 910         
Glu Leu Glu Asp Lys Ala Asn Asn Ser Phe Ile Lys Met Ser Thr Leu
        915                 920                 925             
Arg Tyr Ser Pro Lys Met His Arg Ser Gln Ala Leu Tyr Thr Thr Val
    930                 935                 940                 
Ala Ala Ser Asp Ser Leu Ser Lys Ala Thr Ser Ser Glu Phe Glu Ala
945                 950                 955                 960 
Lys Glu Asn Leu Pro Ser Glu Ser Val Met Ser Leu Lys Pro Thr Ser
                965                 970                 975     
Val Gly Val Pro Glu Thr Leu Ile Leu Thr Ala Asn Ser Arg Thr Lys
            980                 985                 990         
Asp Thr Ala Ala Pro Arg Leu Ala Lys Ser Glu Asn Leu His His His
        995                 1000                1005            
Pro Thr Met Leu Ile Ser Thr Ala Ser Glu Pro Met Pro Thr Tyr Phe
    1010                1015                1020                
Ala Tyr Phe Lys Glu Gly Ile Ile Ser Gly Arg Gln Asn Ile Lys Ser
1025                1030                1035                1040
Gln Ile Val Leu Asn Ala Leu Pro Leu Val Cys Ile Val Leu Gln Ala
                1045                1050                1055    
Ala Ser Thr Asp Ser Ser Asp Asn Thr Gly Asp Val Lys Pro Asn Thr
            1060                1065                1070        
Ser Ala Thr Leu Ile Thr Arg Tyr Lys Ile Phe Asp Ile Asp Ala Ser
        1075                1080                1085            
Ala Ile
    1090


<210> 2577
<211> 479
<212> PRT
<213> Homo sapiens

<400> 2577
Met Met Ile Val Phe Ser Ser His Leu Gln Met Ala Ser Phe Phe Gly
 1               5                  10                  15      
Lys Met Ile Asn Leu Ser Glu Pro Asp Thr Ile Asp Glu Arg Ala Ile
            20                  25                  30          
Asn Lys Lys Lys Leu Thr Pro Phe Thr Ile Ser Glu Asn Leu Asn Leu
        35                  40                  45              
Ala Leu Asn Ser Ala Ser Ala Ile Gly Cys Thr Val Val Asn Ile Gly
    50                  55                  60                  
Ala Ser Asp Leu Lys Glu Gly Lys Pro His Leu Val Leu Gly Leu Leu
65                  70                  75                  80  
Trp Gln Ile Ile Lys Val Gly Leu Phe Ala Asp Ile Glu Ile Ser Arg
                85                  90                  95      
Asn Glu Ala Leu Ile Ala Leu Leu Asn Glu Gly Glu Glu Leu Glu Glu
            100                 105                 110         
Leu Met Lys Leu Ser Pro Glu Glu Leu Leu Leu Arg Trp Val Asn Tyr
        115                 120                 125             
His Leu Thr Asn Ala Gly Trp His Thr Ile Ser Asn Phe Ser Gln Asp
    130                 135                 140                 
Ile Lys Asp Ser Arg Ala Tyr Phe His Leu Leu Asn Gln Ile Ala Pro
145                 150                 155                 160 
Lys Gly Gly Glu Asp Gly Pro Ala Ile Ala Ile Asp Leu Ser Gly Ile
                165                 170                 175     
Asn Glu Thr Asn Asp Leu Lys Arg Ala Gly Leu Met Leu Gln Glu Ala
            180                 185                 190         
Asp Lys Leu Gly Cys Lys Gln Phe Val Thr Pro Ala Asp Val Val Ser
        195                 200                 205             
Gly Asn Pro Lys Leu Asn Leu Ala Phe Val Ala Asn Leu Phe Asn Thr
    210                 215                 220                 
Tyr Pro Cys Leu His Lys Pro Asn Asn Asn Asp Ile Asp Met Asn Leu
225                 230                 235                 240 
Leu Glu Gly Glu Ser Lys Glu Glu Arg Thr Phe Arg Asn Trp Met Asn
                245                 250                 255     
Ser Leu Gly Val Asn Pro Tyr Ile Asn His Leu Tyr Ser Asp Leu Ala
            260                 265                 270         
Asp Ala Leu Val Ile Phe Gln Leu Tyr Glu Met Ile Arg Val Pro Val
        275                 280                 285             
Asn Trp Ser His Val Asn Lys Pro Pro Tyr Pro Ala Leu Gly Gly Asn
    290                 295                 300                 
Met Lys Lys Ile Glu Asn Cys Asn Tyr Ala Val Glu Leu Gly Lys Asn
305                 310                 315                 320 
Lys Ala Lys Phe Ser Leu Val Gly Ile Ala Gly Gln Asp Leu Asn Glu
                325                 330                 335     
Gly Asn Ser Thr Leu Thr Leu Ala Leu Val Trp Gln Leu Met Arg Arg
            340                 345                 350         
Tyr Thr Leu Asn Val Leu Ser Asp Leu Gly Glu Gly Glu Lys Val Asn
        355                 360                 365             
Asp Glu Ile Ile Ile Lys Trp Val Asn Gln Thr Leu Lys Ser Ala Asn
    370                 375                 380                 
Lys Lys Thr Ser Ile Ser Ser Phe Lys Asp Lys Ser Ile Ser Thr Ser
385                 390                 395                 400 
Leu Pro Val Leu Asp Leu Ile Asp Ala Ile Ala Pro Asn Ala Val Arg
                405                 410                 415     
Gln Glu Met Ile Arg Arg Glu Asn Leu Ser Asp Glu Asp Lys Leu Asn
            420                 425                 430         
Asn Ala Lys Tyr Ala Ile Ser Val Ala Arg Lys Ile Gly Ala Arg Ile
        435                 440                 445             
Tyr Ala Leu Pro Asp Asp Leu Val Glu Val Lys Pro Lys Met Val Met
    450                 455                 460                 
Thr Val Phe Ala Cys Leu Met Gly Lys Gly Leu Asn Arg Ile Lys
465                 470                 475                 


<210> 2578
<211> 443
<212> PRT
<213> Homo sapiens

<400> 2578
Met Ala Gly Gly Leu Ala Gly Ile Gly Gly Ile Gln His Glu Lys Glu
 1               5                  10                  15      
Thr Met Gln Ser Leu Lys Asp Cys Leu Ala Ser Tyr Leu Asp Arg Thr
            20                  25                  30          
Ile Gln Asn Leu Arg Ile Gln Ile Phe Ala Asn Thr Val Asp Asn Ala
        35                  40                  45              
Cys Ile Val Leu Gln Ile Asp Asn Ala Arg Leu Ala Ala Asp Asp Phe
    50                  55                  60                  
Arg Val Lys Tyr Glu Thr Glu Leu Ala Met Arg Gln Ser Val Glu Asn
65                  70                  75                  80  
Asp Ile His Gly Leu Arg Asn Val Ile Asp Asp Thr Val Thr Arg Leu
                85                  90                  95      
Gln Leu Glu Thr Glu Ile Glu Ala Val Lys Glu Glu Leu Leu Phe Met
            100                 105                 110         
Lys Lys Asn His Lys Glu Glu Ala Lys Ser Leu Gln Ala Gln Ile Ala
        115                 120                 125             
Ser Ser Gly Leu Met Val Glu Val Asp Ala Pro Lys Ser Gln Asp Leu
    130                 135                 140                 
Ala Lys Val Met Ala Asp Ile Arg Ala Gln Tyr Asp Glu Leu Ala Gln
145                 150                 155                 160 
Lys Asn Gly Glu Glu Leu Asp Lys His Trp Pro Gln Gln Ile Glu Glu
                165                 170                 175     
Ser Thr Thr Val Val Thr Thr Gln Ser Ala Glu Val Gly Ala Ala Glu
            180                 185                 190         
Thr Thr Leu Thr Glu Leu Arg Leu Leu Gly Asp Asp Leu Asp Ser Met
        195                 200                 205             
Arg Asn Leu Lys Ala Ser Leu Glu Ser Glu Glu Gln Pro Glu Gly Gly
    210                 215                 220                 
Gly Gly Pro Leu Arg Pro Ala Asp Gly Ala Val Gln Trp Asp Pro Ala
225                 230                 235                 240 
Ala Pro Gly Val Arg Ala Gly Thr Asp Pro Gly Arg Gly Thr Ala Pro
                245                 250                 255     
Gly Pro Gly Val Gly Gly Pro Ala Glu Arg Gln Asp Gly Glu Asp Phe
            260                 265                 270         
Asn Phe Gly Asp Ala Leu Asp Ser Ser Asn Ser Met Gln Thr Ile Gln
        275                 280                 285             
Lys Thr Thr Thr Thr His Arg Thr Val Asp Gly Lys Val Val Ser Glu
    290                 295                 300                 
Thr His Asp Thr Lys Val Leu Arg His Ser Ala Asn Arg Ser Arg Val
305                 310                 315                 320 
Pro Phe Gly Glu Gln Glu Ala Asn Lys Lys Phe Arg Val Cys Cys Gln
                325                 330                 335     
Thr Ala Ile Arg Ser Glu Cys Phe Ala Val Tyr Pro Asp Leu Ala Phe
            340                 345                 350         
Ala Arg Lys Ala Tyr Trp Val Gln Cys Gly Thr Ile Leu Arg Thr Arg
        355                 360                 365             
Pro Trp Val Leu Asp Tyr Tyr Cys Asn Arg Glu Ile Asn Ile Phe His
    370                 375                 380                 
Gly Cys Ala His Gln Gln Lys Glu Ala Ala Gln Ala Glu Ala Leu Pro
385                 390                 395                 400 
Leu Ala Phe Gln Ile Thr Cys Gly Tyr Pro Asp Lys Gln Met Leu Leu
                405                 410                 415     
Ile Leu Lys Met Glu Phe Gln Phe Ser Ser Arg Ile Pro Gly Ala Phe
            420                 425                 430         
Arg Ser Thr Ile His Val Lys Trp Val Leu Gly
        435                 440             


<210> 2579
<211> 191
<212> PRT
<213> Homo sapiens

<400> 2579
Met Pro Glu Ser Ser Asp Arg Asn Glu Asn Thr Gly Arg Ala Thr Leu
 1               5                  10                  15      
Ala Ala Val Gly Thr Met Glu Arg Arg Pro Phe Glu Asn Glu Leu Asp
            20                  25                  30          
His Glu Gly Gly Ala Ala Phe Ala Arg Glu Glu Thr Leu His Gln Thr
        35                  40                  45              
Asp Leu Phe Ser Thr Gln Ser Asp His Thr Phe Leu Leu Met Thr Lys
    50                  55                  60                  
Ser Ser Leu His Gly Ser Thr Val Lys Glu Glu Phe Ser Glu Ser Ile
65                  70                  75                  80  
Tyr Leu Gly Cys Ala Phe Ile Pro His Thr His Arg Pro His Lys Asp
                85                  90                  95      
Asp Ala Ala Glu Ala Leu Gly Asn Trp Leu Phe His Pro Gly Cys Leu
            100                 105                 110         
Ile Gly Glu Trp Leu Arg Leu Glu Pro Met Ser Ser His Pro Arg Cys
        115                 120                 125             
Ile Thr Val Ala Val Thr Leu Ser Gly Glu Ser Val Gly Arg Ala Asp
    130                 135                 140                 
Met Ser Gly Ala Leu Pro Asp Glu Glu Asn Gly Gly Ser Pro Gly Glu
145                 150                 155                 160 
Tyr Lys Gly Ala Leu Gly Asn Asp Leu Gly Asp Tyr Arg Glu Leu Ser
                165                 170                 175     
Leu Phe Thr Cys Thr Gln Lys Ser Cys Gly Ile Tyr Gln Ser His
            180                 185                 190     


<210> 2580
<211> 180
<212> PRT
<213> Homo sapiens

<400> 2580
Met Ser Ser Gly Val Arg Asp Phe Ala Ser Phe Ala Gly Cys Gly Gly
 1               5                  10                  15      
Arg Gly Leu Ser Ala Pro Arg Ala Ala Lys Pro Gln Cys Arg Thr Pro
            20                  25                  30          
Thr Lys Leu Pro Cys Trp Ala Gln Leu Ser Gly Gly Thr Phe Asn Thr
        35                  40                  45              
Ala Val Val Leu Pro Asp Arg Thr Thr Gln Val Pro Pro Pro Thr Gly
    50                  55                  60                  
Ser Asn Gly Lys Ile Phe Tyr Cys Leu Ile Glu Gly Asn Arg Asn Ala
65                  70                  75                  80  
Thr Thr Phe Thr Arg Ile Met Met Gly Ile Asp Gly Cys Ser Trp Trp
                85                  90                  95      
Asn Pro Val His Ser Leu Met Glu Val Asp Val Leu Gln Arg Glu Gly
            100                 105                 110         
Thr Val Ser Arg Asn Val Ala Val Lys Phe Ser His Ser Lys Pro Gly
        115                 120                 125             
Thr Pro Ala Gly Arg Leu Ala Ser Ala Met His Glu Ala Lys Tyr Leu
    130                 135                 140                 
Ile Pro Asn Ile Cys Lys Asp Asn Lys Gly Met Gln Leu Glu Ser Ala
145                 150                 155                 160 
Ala Val Cys Thr Asp Thr Arg Ser Asp Ile Gly Asp Thr Gly Thr Thr
                165                 170                 175     
Val Lys Leu Tyr
            180 


<210> 2581
<211> 748
<212> PRT
<213> Homo sapiens

<400> 2581
Met Asn Leu Leu Tyr Arg Lys Thr Lys Leu Glu Trp Arg Gln His Lys
 1               5                  10                  15      
Glu Glu Glu Ala Lys Arg Ser Ser Ser Lys Glu Val Ala Pro Ala Gly
            20                  25                  30          
Ser Ala Gly Pro Ala Ala Gly Gln Gly Pro Gly Val Arg Val Arg Asp
        35                  40                  45              
Ile Ala Ser Leu Arg Arg Ser Leu Arg Met Gly Phe Met Thr Met Pro
    50                  55                  60                  
Ala Ser Gln Glu His Thr Pro His Pro Cys Arg Ser Ala Met Ala Pro
65                  70                  75                  80  
Arg Ser Leu Ser Cys His Ser Val Gly Ser Met Asp Ser Val Gly Gly
                85                  90                  95      
Gly Pro Gly Gly Ala Ser Gly Gly Leu Thr Glu Asp Ser Ser Thr Arg
            100                 105                 110         
Arg Pro Pro Ala Lys Pro Arg Arg His Pro Ser Thr Lys Leu Ser Met
        115                 120                 125             
Val Gly Pro Gly Ser Gly Ala Glu Thr Pro Pro Ser Lys Lys Ala Gly
    130                 135                 140                 
Ser Gln Lys Pro Thr Pro Glu Gly Arg Glu Ser Ser Arg Lys Val Pro
145                 150                 155                 160 
Pro Gln Lys Pro Arg Arg Ser Pro Asn Thr Gln Leu Ser Val Ser Phe
                165                 170                 175     
Asp Glu Ser Cys Pro Pro Gly Pro Ser Pro Arg Gly Gly Asn Leu Pro
            180                 185                 190         
Leu Gln Arg Leu Thr Arg Gly Ser Arg Val Ala Gly Asp Pro Asp Val
        195                 200                 205             
Gly Ala Gln Glu Glu Pro Val Tyr Ile Glu Met Val Gly Asp Val Phe
    210                 215                 220                 
Arg Gly Gly Gly Arg Ser Gly Gly Gly Leu Ala Gly Pro Pro Leu Gly
225                 230                 235                 240 
Gly Gly Gly Pro Thr Pro Pro Ala Gly Ala Asp Ser Asp Ser Glu Glu
                245                 250                 255     
Ser Glu Ala Ile Tyr Glu Glu Met Lys Tyr Pro Leu Pro Glu Glu Ala
            260                 265                 270         
Gly Glu Gly Arg Ala Asn Gly Pro Pro Pro Leu Thr Ala Thr Ser Pro
        275                 280                 285             
Pro Gln Gln Pro His Ala Leu Pro Pro His Ala His Arg Arg Pro Ala
    290                 295                 300                 
Ser Ala Leu Pro Ser Arg Arg Asp Gly Thr Pro Thr Lys Thr Thr Pro
305                 310                 315                 320 
Cys Glu Ile Pro Pro Pro Phe Pro Asn Leu Leu Gln His Arg Pro Pro
                325                 330                 335     
Leu Leu Ala Phe Pro Gln Ala Lys Ser Ala Ser Arg Thr Pro Gly Asp
            340                 345                 350         
Gly Val Ser Arg Leu Pro Val Leu Cys His Ser Lys Glu Pro Ala Gly
        355                 360                 365             
Ser Thr Pro Ala Pro Gln Asp Lys Ala Val Ser Tyr Thr Met Val Tyr
    370                 375                 380                 
Ser Ala Val Lys Val Thr Thr His Ser Val Leu Pro Ala Gly Pro Pro
385                 390                 395                 400 
Leu Gly Ala Gly Glu Pro Lys Thr Glu Lys Glu Ile Ser Val Leu His
                405                 410                 415     
Gly Met Leu Cys Thr Ser Ser Arg Pro Pro Val Pro Gly Lys Thr Ser
            420                 425                 430         
Pro His Gly Gly Ala Met Gly Ala Ala Ala Gly Val Leu His His Arg
        435                 440                 445             
Gly Cys Leu Ala Ser Pro His Ser Leu Pro Asp Pro Thr Val Gly Pro
    450                 455                 460                 
Leu Thr Pro Leu Trp Thr Tyr Pro Ala Thr Ala Ala Gly Leu Lys Arg
465                 470                 475                 480 
Pro Pro Ala Tyr Glu Ser Leu Lys Ala Gly Gly Val Leu Asn Lys Gly
                485                 490                 495     
Cys Gly Val Gly Ala Pro Ser Pro Met Val Lys Ile Gln Leu Gln Glu
            500                 505                 510         
Gln Gly Thr Asp Gly Gly Ala Phe Ala Ser Ile Ser Cys Ala His Val
        515                 520                 525             
Ile Ala Ser Ala Gly Thr Pro Glu Glu Glu Glu Glu Glu Val Gly Ala
    530                 535                 540                 
Ala Thr Phe Gly Ala Gly Trp Ala Leu Gln Arg Lys Val Leu Tyr Gly
545                 550                 555                 560 
Gly Arg Lys Ala Lys Glu Leu Asp Thr Glu Val Glu Asp Gly Ala Arg
                565                 570                 575     
Ala Trp Asn Gly Ser Ala Glu Gly Pro Gly Lys Val Glu Arg Glu Asp
            580                 585                 590         
Arg Gly Pro Gly Thr Ser Gly Ile Pro Val Arg Ser Gln Gly Ala Glu
        595                 600                 605             
Gly Leu Leu Ala Arg Ile His His Gly Asp Arg Gly Gly Ser Arg Thr
    610                 615                 620                 
Ala Leu Pro Ile Pro Cys Gln Thr Phe Pro Ala Cys His Arg Asn Gly
625                 630                 635                 640 
Asp Phe Thr Gly Gly Tyr Arg Leu Gly Arg Ser Ala Ser Thr Ser Gly
                645                 650                 655     
Val Arg Gln Val Val Leu His Thr Pro Arg Pro Cys Ser Gln Pro Arg
            660                 665                 670         
Asp Ala Leu Ser Gln Pro Ala Arg Glu Arg Asp Gly Lys Leu Leu Glu
        675                 680                 685             
Val Ile Glu Arg Lys Arg Cys Val Cys Lys Glu Ile Lys Ala Arg His
    690                 695                 700                 
Arg Pro Asp Arg Gly Leu Cys Lys Gln Glu Ser Met Pro Ile Leu Pro
705                 710                 715                 720 
Ser Trp Arg Arg Gly Pro Glu Pro Arg Lys Ser Gly Thr Pro Pro Cys
                725                 730                 735     
Arg Arg Gln His Thr Val Leu Trp Asp Thr Ala Ile
            740                 745             


<210> 2582
<211> 511
<212> PRT
<213> Homo sapiens

<400> 2582
Met Ala Val Asn Gly Gln Arg Gly Pro Gly Arg Glu Leu His Asp Val
 1               5                  10                  15      
Ile Lys Asn Arg Thr Val Ser Ile Lys Gly Pro Asp Pro Arg Glu His
            20                  25                  30          
His Gly Val Ala Val Gly Arg Ile Arg Ala Asp Gln Glu Val Leu Arg
        35                  40                  45              
Gln Cys Arg Glu Glu Gly Met Leu Ser Val Thr Arg Val Thr Ala Asn
    50                  55                  60                  
Gln Leu Leu Val Ser Gln Thr Ser Gly Thr Ala Asp Pro His Ser Leu
65                  70                  75                  80  
Ser Pro Gly Thr Leu Ser Asp Ser Leu Glu Asp Pro Leu Arg Gly Ser
                85                  90                  95      
Leu Ser Pro Gly Thr Leu Ser Asp Ser Leu Glu Asp Arg Leu Cys Gly
            100                 105                 110         
Ser Leu Ala Ala Ser Ala Pro Gly Pro Ser Val Ile Leu Trp Arg Thr
        115                 120                 125             
Leu Cys Val Ala Ala Ser Gln Pro Gln Pro Arg Asp Pro His Leu Ser
    130                 135                 140                 
Pro Gly Thr Leu Ser Asp Ser Leu Glu Asp Pro Leu Arg Gly Ser Leu
145                 150                 155                 160 
Ser Pro Gly Thr Leu Ser Asp Ser Leu Glu Asp Pro Leu Arg Gly Ser
                165                 170                 175     
Leu Ser Pro Gly Thr Leu Ser Asp Ser Leu Glu Asp Pro Leu Arg Gly
            180                 185                 190         
Ser Leu Ser Pro Gly Thr Leu Ser Asp Ser Leu Glu Asp Pro Leu Arg
        195                 200                 205             
Gly Ser Leu Ser Pro Gly Thr Leu Ser Asp Ser Leu Glu Asp Pro Leu
    210                 215                 220                 
Arg Gly Ser Leu Ser Pro Gly Thr Pro Ser Asp Ser Leu Glu Asp Arg
225                 230                 235                 240 
Leu Cys Gly Ser Leu Ala Ala Ser Ala Pro Gly Pro Ser Val Ile Leu
                245                 250                 255     
Trp Arg Thr Leu Cys Val Ala Ala Ser Gln Pro Gln Pro Arg Asp Pro
            260                 265                 270         
His Leu Ser Pro Gly Thr Leu Ser Asp Ser Leu Glu Asp Pro Leu Arg
        275                 280                 285             
Gly Ser Leu Ser Pro Gly Thr Leu Ser Asp Ser Leu Glu Asp Pro Leu
    290                 295                 300                 
Arg Gly Ser Leu Ser Pro Gly Thr Leu Ser Asp Ser Leu Glu Asp Pro
305                 310                 315                 320 
Leu Arg Gly Ser Leu Ser Pro Gly Thr Leu Ser Asp Ser Leu Glu Asp
                325                 330                 335     
Pro Leu Arg Gly Ser Leu Ser Pro Gly Thr Pro Ser Asp Ser Leu Glu
            340                 345                 350         
Asp Pro Leu Arg Gly Ser Leu Ser Pro Gly Thr Leu Ser Asp Ser Leu
        355                 360                 365             
Glu Asp Pro Leu Arg Gly Ser Leu Ser Pro Gly Thr Leu Ser Asp Ser
    370                 375                 380                 
Leu Glu Asp Pro Leu Arg Gly Ser Leu Ser Pro Gly Thr Leu Ser Asp
385                 390                 395                 400 
Ser Leu Glu Asp Pro Leu Arg Gly Ser Leu Ser Pro Gly Thr Leu Ser
                405                 410                 415     
Asp Ser Leu Glu Asp Pro Leu Arg Gly Ser Leu Ser Pro Gly Thr Leu
            420                 425                 430         
Ser Asp Ser Leu Glu Asp Pro Leu Arg Gly Ser Leu Ser Pro Gly Thr
        435                 440                 445             
Pro Ser Asp Ser Leu Glu Asp Pro Leu Arg Gly Ser Leu Ser Pro Gly
    450                 455                 460                 
Thr Leu Ser Asp Ser Leu Glu Asp Pro Leu Arg Gly Ser Leu Ser Pro
465                 470                 475                 480 
Gly Thr Leu Ser Asp Ser Leu Glu Asp Pro Leu Arg Gly Ser Phe Ala
                485                 490                 495     
Ala Ala Ala Pro Gly Pro Pro His His Cys Arg Arg Leu Ile Leu
            500                 505                 510     


<210> 2583
<211> 129
<212> PRT
<213> Homo sapiens

<400> 2583
Met Ala Asp Ser Gly Asp Ala Gly Ser Ser Gly Pro Trp Trp Lys Ser
 1               5                  10                  15      
Leu Thr Asn Ser Arg Lys Lys Ser Lys Glu Ala Ala Val Gly Val Pro
            20                  25                  30          
Pro Pro Ala Gln Pro Ala Pro Gly Glu Pro Thr Pro Pro Ala Pro Pro
        35                  40                  45              
Ser Pro Asp Trp Thr Ser Ser Ser Arg Glu Asn Gln His Pro Asn Leu
    50                  55                  60                  
Leu Gly Gly Ala Gly Glu Pro Pro Lys Pro Asp Lys Leu Tyr Gly Asp
65                  70                  75                  80  
Lys Ser Gly Ser Ser Arg Arg Asn Leu Lys Ile Ser Arg Ser Gly Arg
                85                  90                  95      
Phe Lys Glu Lys Arg Lys Val Arg Ala Thr Leu Leu Pro Glu Ala Gly
            100                 105                 110         
Arg Ser Pro Glu Glu Ala Gly Phe Pro Gly Asp Pro His Glu Asp Lys
        115                 120                 125             
Gln
    


<210> 2584
<211> 236
<212> PRT
<213> Homo sapiens

<400> 2584
Met Asp Thr Pro Pro Arg Arg Ser Arg Gln Leu Glu Gly Leu Gly Pro
 1               5                  10                  15      
Glu Ser Leu Gln Ser Leu Thr Ser Val Ser Arg Arg Arg Trp Val Leu
            20                  25                  30          
Val Glu Phe Glu Leu Asp Thr Glu Glu Thr Arg Glu Pro Gly Ser Pro
        35                  40                  45              
Pro Ser Val Gln Gln Ala Gly Leu Gly Pro Pro Glu Arg Thr Leu Glu
    50                  55                  60                  
Arg Ser Pro Gly Ser Pro Ser Leu Cys Ser Arg Cys Gln Gln Gly Leu
65                  70                  75                  80  
His Leu Glu Ser Pro Gln Arg Gln Leu Glu Ser Ser Pro Gln Ser Pro
                85                  90                  95      
Arg Cys Gln Pro Lys Pro Ser Glu Glu Ala Pro Lys Cys Ala Gln Gly
            100                 105                 110         
Gln Gly Val Pro Gly Leu Gly Val Gly Pro Asn Lys Glu Glu Leu Ile
        115                 120                 125             
Pro Gly Gly Pro Pro Ala Ser Ala Thr Ala Gly Pro Arg Ile Thr Arg
    130                 135                 140                 
Ala Leu Thr Pro Val Arg Lys Leu Arg Gly Gln His Glu Gln Ser Lys
145                 150                 155                 160 
Pro Pro Pro Ala Gly Glu Met Val Thr Asp Gly Phe Gly Ala Lys Lys
                165                 170                 175     
Pro Lys Gly Ser Ser Ser Gln Ala Pro Ala Ser Lys Lys Leu Lys Glu
            180                 185                 190         
Glu Glu Leu Pro Val Ile Pro Lys Gly Lys Pro Lys Ser Gly Gln Asp
        195                 200                 205             
Lys Pro Leu Arg Ile Ser Trp Gln Arg Lys Met Lys Gln Glu Arg Lys
    210                 215                 220                 
Leu Ala Lys Asp Phe Ala Arg His Leu Glu Glu Glu
225                 230                 235     


<210> 2585
<211> 127
<212> PRT
<213> Homo sapiens

<400> 2585
Met Met Gly Lys Glu Glu Arg Ile Val Arg Ser Pro Asp Pro Gly Leu
 1               5                  10                  15      
Glu Lys Phe Cys Ala Pro Leu Gly Leu Cys Gly Pro Phe Ala Ser Thr
            20                  25                  30          
Asp Leu Ser Leu Pro Arg Leu Pro Leu His Ser Asp Pro Ala Phe Pro
        35                  40                  45              
Ser Val Asn Gln Asn Ile Thr Asn Cys Leu Arg Ile Arg Pro Thr Ser
    50                  55                  60                  
Ser Pro Lys Pro Gly Cys Asp Arg Arg Lys Pro Lys Pro Glu Leu Thr
65                  70                  75                  80  
Phe Pro Arg Thr Arg Arg Ala Pro Trp Thr Arg Arg Asn Pro Ala Glu
                85                  90                  95      
Lys Ala Pro Arg Ser Gly Glu Gly Leu Pro Ala Pro Ser Ser Leu Pro
            100                 105                 110         
Arg Ala Leu Ser Cys Leu Pro Glu Gly Val Lys Ser Leu Trp Arg
        115                 120                 125         


<210> 2586
<211> 221
<212> PRT
<213> Homo sapiens

<400> 2586
Met Asp Gly Thr Leu Leu Arg Glu Thr Pro Thr Thr Gly Pro Gly Glu
 1               5                  10                  15      
Glu Arg Gly Arg Pro His Gly Gly Phe Arg Cys Ser Ser Gly Trp Lys
            20                  25                  30          
Ser Gln Lys Arg Met Tyr Gln Arg Val Val Ser Thr His Thr Pro Ser
        35                  40                  45              
Val Gly Arg Gly Ala Ala Glu Gly Arg Val Ala Phe Gln Phe Glu Ser
    50                  55                  60                  
Arg Pro Glu Met Phe Glu Arg Thr Lys Glu Ser Ser Pro Met Ser Leu
65                  70                  75                  80  
Asp Val Gln Asn Leu Pro Ile Ala Asp Pro Asp Trp Gln Arg Ser Cys
                85                  90                  95      
His Thr His Ala Glu Pro Glu Ser Arg Cys Leu Ser Lys Thr Gln Ile
            100                 105                 110         
Gly Cys Pro Leu Phe Ser Ser Gly Lys Pro Tyr Pro Pro Pro Leu Lys
        115                 120                 125             
Thr Gly Val Ile Cys Pro Ala Ala Leu His Phe Tyr Ser Thr Phe Gly
    130                 135                 140                 
Thr Ser His Thr Lys Thr Cys Val Leu Val Thr Cys Gln Pro Ser Gln
145                 150                 155                 160 
Pro Gly Cys Leu Ala Ile Ser His Arg Arg Gly Gly Ala Pro Gly Cys
                165                 170                 175     
Ser Arg Arg Pro Lys Arg Ala Lys Glu Pro Lys Gln Ile Gly Glu Thr
            180                 185                 190         
Glu Phe Gln Pro Arg Ser Tyr Leu Leu Asn Thr Gln Gly Pro Met Val
        195                 200                 205             
Ala Thr His Thr Asn Ala Leu Ile His Asn Met Lys Asp
    210                 215                 220     


<210> 2587
<211> 753
<212> PRT
<213> Homo sapiens

<400> 2587
Met Lys Glu Arg Lys Arg His Leu Gly Asp Thr Lys His Phe Cys Pro
 1               5                  10                  15      
Val Val Leu Lys Glu Asn Phe Ile Leu Gln Pro Gly Asn Thr Glu Glu
            20                  25                  30          
Ala Ala Lys Tyr Arg Glu Lys Ile Tyr Tyr Phe Ser Ser Ala Glu Ala
        35                  40                  45              
Lys Glu Lys Phe Leu Glu His Pro Glu Asp Tyr Val Ala His Glu Glu
    50                  55                  60                  
Pro Leu Lys Ala Pro Pro Leu Arg Ile Cys Leu Val Gly Pro Gln Gly
65                  70                  75                  80  
Ser Gly Lys Thr Met Cys Gly Arg Gln Leu Ala Glu Lys Leu Asn Ile
                85                  90                  95      
Phe His Ile Gln Phe Glu Glu Val Leu Gln Glu Lys Leu Leu Leu Lys
            100                 105                 110         
Thr Glu Lys Lys Val Gly Pro Glu Phe Glu Glu Asp Ser Glu Asn Glu
        115                 120                 125             
Gln Ala Ala Lys Gln Glu Leu Glu Glu Leu Ala Ile Gln Ala Asn Val
    130                 135                 140                 
Lys Val Glu Glu Glu Asn Thr Lys Lys Gln Leu Pro Glu Val Gln Leu
145                 150                 155                 160 
Thr Glu Glu Glu Glu Val Ile Lys Ser Ser Leu Met Glu Asn Glu Pro
                165                 170                 175     
Leu Pro Pro Glu Ile Leu Glu Val Ile Leu Ser Glu Trp Trp Leu Lys
            180                 185                 190         
Glu Pro Ile Arg Ser Thr Gly Phe Ile Leu Asp Gly Phe Pro Arg Tyr
        195                 200                 205             
Pro Glu Glu Ala Gln Phe Leu Gly Asp Arg Gly Phe Phe Pro Asp Ala
    210                 215                 220                 
Ala Val Phe Ile Gln Val Asp Asp Gln Asp Ile Phe Asp Arg Leu Leu
225                 230                 235                 240 
Pro Ala Gln Ile Glu Lys Trp Lys Leu Lys Gln Lys Lys Lys Leu Glu
                245                 250                 255     
Arg Lys Lys Leu Ile Lys Asp Met Lys Ala Lys Ile Arg Val Asp Thr
            260                 265                 270         
Ile Ala Lys Arg Arg Ala Glu Leu Ile Leu Glu Arg Asp Lys Lys Arg
        275                 280                 285             
Arg Glu Asn Val Val Arg Asp Asp Glu Glu Ile Ser Glu Glu Glu Leu
    290                 295                 300                 
Glu Glu Asp Asn Asp Asp Ile Glu Asn Ile Leu Glu Asp Glu Phe Pro
305                 310                 315                 320 
Lys Asp Glu Glu Glu Met Ser Gly Glu Glu Asp Glu Glu Gln Glu Thr
                325                 330                 335     
Asp Ala Ile Glu Arg Leu Arg Gly Glu Leu Gly Glu Lys Phe Glu Ala
            340                 345                 350         
Asp Thr His Asn Leu Gln Ile Ile Gln Leu Ser Glu Gly Glu Thr Ile
        355                 360                 365             
Lys Pro Val Glu Asn Ala Glu Asn Pro Ile Tyr Pro Val Ile His Arg
    370                 375                 380                 
Gln Tyr Ile Tyr Phe Leu Ser Ser Lys Glu Thr Lys Glu Lys Phe Met
385                 390                 395                 400 
Lys Asn Pro Ile Lys Tyr Ile Arg Gln Pro Lys Pro Lys Pro Thr Val
                405                 410                 415     
Pro Ile Arg Ile Ile Ile Val Gly Pro Pro Lys Ser Gly Lys Thr Thr
            420                 425                 430         
Val Ala Lys Lys Ile Thr Ser Glu Tyr Gly Leu Lys His Leu Ser Ile
        435                 440                 445             
Gly Gly Ala Leu Arg Tyr Val Leu Asn Asn His Pro Glu Thr Glu Leu
    450                 455                 460                 
Ala Leu Met Leu Asn Trp His Leu His Lys Gly Met Thr Ala Pro Asp
465                 470                 475                 480 
Glu Leu Ala Ile Gln Ala Leu Glu Leu Ser Leu Met Glu Ser Val Cys
                485                 490                 495     
Asn Thr Ala Gly Val Val Ile Asp Gly Tyr Pro Val Thr Lys His Gln
            500                 505                 510         
Met Asn Leu Leu Glu Ala Arg Ser Ile Ile Pro Met Val Ile Phe Glu
        515                 520                 525             
Leu Ser Val Pro Ser Lys Glu Ile Phe Lys Arg Leu Leu Leu Glu Lys
    530                 535                 540                 
Glu Asn Glu Gln Arg Leu Pro Tyr Pro Leu His Asn Ser Ala Gln Ile
545                 550                 555                 560 
Val Ala Val Asn Asn Val Lys Tyr Arg Lys Asn Ile Gly Glu Ile Arg
                565                 570                 575     
Gln Tyr Tyr Gln Glu Gln His Gln Asn Trp Tyr Val Ile Asp Gly Phe
            580                 585                 590         
His Ser Lys Trp Trp Val Trp Asn Glu Val Ile Lys Asn Val Gln Met
        595                 600                 605             
Val Asn Lys Tyr Met Gln Thr Tyr Leu Glu Arg Ile Lys Ala Gly Lys
    610                 615                 620                 
Ala Ala Cys Ile Asp Lys Leu Cys Ile Thr Pro Gln Glu Leu Leu Ser
625                 630                 635                 640 
Arg Leu Gly Glu Phe Glu Gln Phe Cys Pro Val Ser Leu Ala Glu Ser
                645                 650                 655     
Gln Glu Leu Phe Asp Cys Ser Ala Thr Asp Ser Leu Glu Phe Ala Ala
            660                 665                 670         
Glu Phe Arg Gly His Tyr Tyr Lys Met Ser Ser Gln Glu Lys Leu Asn
        675                 680                 685             
Lys Phe Leu Glu Asn Pro Glu Leu Tyr Val Pro Pro Leu Ala Pro His
    690                 695                 700                 
Pro Leu Pro Ser Ala Asp Met Ile Pro Lys Arg Leu Thr Leu Ser Glu
705                 710                 715                 720 
Leu Lys Ser Arg Phe Pro Lys Cys Ala Glu Leu Gln Gly Tyr Cys Pro
                725                 730                 735     
Val Thr Tyr Lys Asp Gly Asn Gln Arg Gln Val Leu Ala Phe Met Glu
            740                 745                 750         
Val
    


<210> 2588
<211> 202
<212> PRT
<213> Homo sapiens

<400> 2588
Met Ala Ala Tyr Lys Leu Val Leu Ile Arg His Gly Glu Ser Ala Trp
 1               5                  10                  15      
Asn Leu Glu Asn Arg Phe Ser Gly Trp Tyr Asp Ala Asp Leu Ser Pro
            20                  25                  30          
Ala Gly His Glu Glu Ala Lys Arg Gly Gly Gln Ala Leu Arg Asp Ala
        35                  40                  45              
Gly Tyr Glu Phe Asp Ile Cys Phe Thr Ser Val Gln Lys Ile Trp Arg
    50                  55                  60                  
Arg Ser Tyr Asp Val Pro Pro Pro Pro Met Glu Pro Asp His Pro Phe
65                  70                  75                  80  
Tyr Ser Asn Ile Ser Lys Asp Arg Arg Tyr Ala Asp Leu Thr Glu Asp
                85                  90                  95      
Gln Leu Pro Ser Cys Glu Ser Leu Lys Asp Thr Ile Ala Arg Ala Leu
            100                 105                 110         
Pro Phe Trp Asn Glu Glu Ile Val Pro Gln Ile Lys Glu Gly Lys Arg
        115                 120                 125             
Val Leu Ile Ala Ala His Gly Asn Ser Leu Arg Gly Ile Val Lys His
    130                 135                 140                 
Leu Glu Gly Leu Ser Glu Glu Ala Ile Met Glu Leu Asn Leu Pro Thr
145                 150                 155                 160 
Gly Ile Pro Ile Val Tyr Glu Leu Asp Lys Asn Leu Lys Pro Ile Lys
                165                 170                 175     
Pro Met Gln Phe Leu Gly Asp Glu Glu Thr Val Arg Lys Ala Met Glu
            180                 185                 190         
Ala Val Ala Ala Gln Gly Lys Ala Lys Lys
        195                 200         


<210> 2589
<211> 458
<212> PRT
<213> Homo sapiens

<400> 2589
Met Ala Arg Gly Pro Gln Thr Leu Val Gln Val Trp Val Gly Gly Gln
 1               5                  10                  15      
Leu Phe Gln Ala Asp Arg Ala Leu Leu Val Glu His Cys Gly Phe Phe
            20                  25                  30          
Arg Gly Leu Phe Arg Ser Gly Met Arg Glu Thr Arg Ala Ala Glu Val
        35                  40                  45              
Arg Leu Gly Val Leu Ser Ala Gly Gly Phe Arg Ala Thr Leu Gln Val
    50                  55                  60                  
Leu Arg Gly Asp Arg Pro Ala Leu Ala Ala Glu Asp Glu Leu Leu Gln
65                  70                  75                  80  
Ala Val Glu Cys Ala Ala Phe Leu Gln Ala Pro Ala Leu Ala Arg Phe
                85                  90                  95      
Leu Glu His Asn Leu Thr Ser Asp Asn Cys Ala Leu Leu Cys Asp Ala
            100                 105                 110         
Ala Ala Ala Phe Gly Leu Arg Asp Val Phe His Ser Ala Ala Leu Phe
        115                 120                 125             
Ile Cys Asp Gly Glu Arg Glu Leu Ala Ala Glu Leu Ala Leu Pro Glu
    130                 135                 140                 
Ala Arg Ala Tyr Val Ala Ala Leu Arg Pro Ser Ser Tyr Ala Ala Val
145                 150                 155                 160 
Ser Thr His Thr Pro Ala Pro Gly Phe Leu Glu Asp Ala Ser Arg Thr
                165                 170                 175     
Leu Cys Tyr Leu Asp Glu Glu Glu Asp Ala Trp Arg Thr Leu Ala Ala
            180                 185                 190         
Leu Pro Leu Glu Ala Ser Thr Leu Leu Ala Gly Val Ala Thr Leu Gly
        195                 200                 205             
Asn Lys Leu Tyr Ile Val Gly Gly Val Arg Gly Ala Ser Lys Glu Val
    210                 215                 220                 
Val Glu Leu Gly Phe Cys Tyr Asp Pro Asp Gly Gly Thr Trp His Glu
225                 230                 235                 240 
Phe Pro Ser Pro His Gln Pro Arg Tyr Asp Thr Ala Leu Ala Gly Phe
                245                 250                 255     
Asp Gly Arg Leu Tyr Ala Ile Gly Gly Glu Phe Gln Arg Thr Pro Ile
            260                 265                 270         
Ser Ser Val Glu Arg Tyr Asp Pro Ala Ala Gly Cys Trp Ser Phe Val
        275                 280                 285             
Ala Asp Leu Pro Gln Pro Ala Ala Gly Val Pro Cys Ala Gln Ala Cys
    290                 295                 300                 
Gly Arg Leu Phe Val Cys Leu Trp Arg Pro Ala Asp Thr Thr Ala Val
305                 310                 315                 320 
Val Glu Tyr Ala Val Arg Thr Asp Ala Trp Leu Pro Val Ala Glu Leu
                325                 330                 335     
Arg Arg Pro Gln Ser Tyr Gly His Cys Met Val Ala His Arg Asp Ser
            340                 345                 350         
Leu Tyr Val Val Arg Asn Gly Pro Ser Asp Asp Phe Leu His Cys Ala
        355                 360                 365             
Ile Asp Cys Leu Asn Leu Ala Thr Gly Gln Trp Thr Ala Leu Pro Gly
    370                 375                 380                 
Gln Phe Val Asn Ser Lys Gly Ala Leu Phe Thr Ala Val Val Arg Gly
385                 390                 395                 400 
Asp Thr Val Tyr Thr Val Asn Arg Met Phe Thr Leu Leu Tyr Ala Ile
                405                 410                 415     
Glu Gly Gly Thr Trp Arg Leu Leu Arg Glu Lys Ala Gly Phe Pro Arg
            420                 425                 430         
Pro Gly Ser Leu Gln Thr Phe Leu Leu Arg Leu Pro Pro Gly Ala Pro
        435                 440                 445             
Gly Pro Val Thr Ser Thr Thr Ala Glu Leu
    450                 455             


<210> 2590
<211> 110
<212> PRT
<213> Homo sapiens

<400> 2590
Met Leu Ala Val Asp Ala Val Ile Ala Glu Leu Arg Lys Gln Ser Lys
 1               5                  10                  15      
Phe Val Thr Thr Pro Glu Glu Ile Ala Gln Val Ala Thr Thr Ser Ala
            20                  25                  30          
Asn Gly Asp Lys Glu Ile Gly Asn Ile Ile Ser Asn Ala Met Lys Lys
        35                  40                  45              
Val Gly Arg Lys Gly Val Ile Thr Val Lys Asp Gly Lys Thr Leu Asn
    50                  55                  60                  
Asp Glu Leu Glu Ile Ile Glu Gly Met Lys Phe Asp Arg Gly Tyr Ile
65                  70                  75                  80  
Ser Ser Tyr Phe Ile Asn Thr Pro Lys Gly Gln Lys Cys Glu Phe Gln
                85                  90                  95      
Asp Ala Tyr Val Leu Leu Ser Glu Lys Lys Ile Ser Ser Val
            100                 105                 110 


<210> 2591
<211> 141
<212> PRT
<213> Homo sapiens

<400> 2591
Met Ala Pro Lys Val Phe Arg Gln Tyr Trp Asp Ile Pro Asp Gly Thr
 1               5                  10                  15      
Asp Cys His Arg Lys Ala Tyr Ser Thr Thr Ser Ile Ala Ser Val Ala
            20                  25                  30          
Gly Leu Thr Ala Ala Ala Tyr Arg Val Thr Leu Asn Pro Pro Gly Thr
        35                  40                  45              
Phe Leu Glu Gly Val Ala Lys Val Gly Gln Tyr Thr Phe Thr Ala Ala
    50                  55                  60                  
Ala Val Gly Ala Val Phe Gly Leu Thr Thr Cys Ile Ser Ala His Val
65                  70                  75                  80  
Arg Glu Lys Pro Asp Asp Pro Leu Asn Tyr Phe Leu Gly Gly Cys Ala
                85                  90                  95      
Gly Gly Leu Thr Leu Gly Ala Arg Thr His Asn Tyr Gly Ile Gly Ala
            100                 105                 110         
Ala Ala Cys Val Tyr Phe Gly Ile Ala Ala Ser Leu Val Lys Met Gly
        115                 120                 125             
Arg Leu Glu Gly Trp Glu Val Phe Ala Lys Pro Lys Val
    130                 135                 140     


<210> 2592
<211> 104
<212> PRT
<213> Homo sapiens

<400> 2592
Met Thr Phe Leu Glu Ser Ser Ala Val Pro Pro His Trp Thr Gly Gln
 1               5                  10                  15      
Asp Gly Arg Val Cys Trp Thr Gly Trp Ile Pro Gln Cys Gln Ala Gly
            20                  25                  30          
Ser Ala Pro Glu Val Leu Glu Cys Leu Ser Thr Gln Gln Val Lys Ser
        35                  40                  45              
Leu Gln Thr Leu Gly Gly Ala Ala Val Ser His Lys Thr Asn Ser Cys
    50                  55                  60                  
Leu Pro Leu Val Gln Pro Cys His Trp Arg Leu Ser Gln Gly Lys Glu
65                  70                  75                  80  
Leu Gly Val Asp Asp Gly Lys His Arg Leu Thr Thr Pro Met Thr Val
                85                  90                  95      
Pro Gln Arg Ala Val Gln Gln Leu
            100                 


<210> 2593
<211> 563
<212> PRT
<213> Homo sapiens

<400> 2593
Met Thr Pro Pro Pro Pro Ser Pro Leu Leu Gly Thr Gln Val Lys Glu
 1               5                  10                  15      
Asp Arg Ala Asp Tyr Lys Glu Phe Gln Asp Phe Ser Ser Leu Pro Asp
            20                  25                  30          
Thr His Asn Ile Ala Trp Asp His Ser Phe Tyr Pro Phe Gln Glu Glu
        35                  40                  45              
Glu Glu His Gly Val Lys Gly Val Glu Ser Val Leu Glu Lys Gly Val
    50                  55                  60                  
Leu Asp Glu Gly Val Leu Glu Ala Trp Gly Cys Cys Arg Arg Cys Arg
65                  70                  75                  80  
His Ala Gly Trp Asn Arg Ser Gln Pro Ser Pro Glu Leu Ala Gly Ala
                85                  90                  95      
Val Val His Ala Arg Ala Pro Ala Val Gly Cys Arg Gln Arg Ser Gly
            100                 105                 110         
His Leu His Val Arg Leu Lys Gln Arg Leu Leu Glu Arg Pro Cys Gln
        115                 120                 125             
Glu Pro Leu Gly Lys Lys Tyr Gln Leu Glu Leu Pro Pro Leu Tyr Glu
    130                 135                 140                 
Arg Ala Arg Asn Ala Glu Gly Ser Lys Asn Leu Pro Ala Asp Gly Gln
145                 150                 155                 160 
Gly Leu Arg Ala Val Arg Ala Asp Ala Ala Leu Pro Val Trp Pro Gly
                165                 170                 175     
Gly Arg Gly Ala Leu Asp His Met Thr Val Cys Leu Gln Ser Ser Leu
            180                 185                 190         
Cys Leu Gly Lys Arg Leu Leu Ala Val Gln Glu Ile Leu Ala Ala Gln
        195                 200                 205             
Glu Ile Leu Val Thr Arg Arg Gly Ala Pro Glu Ala Gly Ala Glu Gly
    210                 215                 220                 
Gln His Gln Gly Gln Trp Pro Pro Ala Asp Thr Arg His Leu Arg Thr
225                 230                 235                 240 
Pro Lys Trp Pro Tyr Lys Val Ala Thr Glu Glu Lys Pro Glu Ala Glu
                245                 250                 255     
Glu Ala Glu Lys Lys Arg Gln Ala Lys Val Gln Glu Lys Arg Leu Pro
            260                 265                 270         
Pro Trp Lys Lys Arg Thr Gly His Asp Gly Ser Leu Phe Leu Met Cys
        275                 280                 285             
Ser Ser Leu Asn Gln Val His Arg Val Pro Trp Gly Gln His Arg Ala
    290                 295                 300                 
Cys Gln Val Met Leu Leu Val Ser Thr Lys Gln Leu Gln Arg Tyr Leu
305                 310                 315                 320 
His Phe Glu Lys Pro Ala Arg Pro Ala Ser Met Gly Gln Asp Pro Asp
                325                 330                 335     
Cys Phe Gly Lys Ser Glu Glu Lys Ile Thr Thr Ser Arg Arg Gly Ser
            340                 345                 350         
Gly Gly Thr Gly Lys Pro Asp Leu Pro Cys Ser Phe Gly Met Ala Pro
        355                 360                 365             
Val Glu Arg Leu Asp Phe Glu Asn Pro Pro Asp Pro Thr Glu Arg Arg
    370                 375                 380                 
Val Ile Pro Asp Trp Ile Pro Asp Ser Pro Trp Ser Leu Trp Ala His
385                 390                 395                 400 
Ser Arg Arg Asp Leu Pro Val Gly Ser Pro Ser Leu Trp Pro Met Arg
                405                 410                 415     
Gln Val Gln Cys Gly Gly Glu Ser Val Val Gly Glu Thr Glu Ala Pro
            420                 425                 430         
Gly Val Arg Pro Asp Pro Arg Pro Glu Lys Asp Ala Lys Pro Ala Val
        435                 440                 445             
Ser Gly Cys Gln Glu Glu Ser Trp Leu Gln Ser Glu Tyr Asp Glu Met
    450                 455                 460                 
His Pro Arg Glu Glu Met Asn Val Pro Ser Leu Arg Ser Gly Ser Gly
465                 470                 475                 480 
Cys Gln Val Ser Gly Ser Pro Leu Ala Lys Gly Leu His Pro Leu Gln
                485                 490                 495     
Pro Cys His Pro His Tyr Met Met Trp Glu Cys Cys Leu Phe Thr Leu
            500                 505                 510         
Thr Leu Gly Thr Gln Ala Cys Phe Glu Val Cys Ala Arg Arg Leu Lys
        515                 520                 525             
Leu Ala His Phe Cys Pro Asp Thr Ser Leu Trp Ser Cys Gly Gly Gln
    530                 535                 540                 
Ser Pro Pro Val Leu Cys Gln Leu Leu Asp Ile Ile Ser Val Ser Arg
545                 550                 555                 560 
Asp Lys Val
            


<210> 2594
<211> 577
<212> PRT
<213> Homo sapiens

<400> 2594
Met Thr Gln Phe Ser Met Asp Lys Arg Gln Gly Arg Ser Arg Ser Val
 1               5                  10                  15      
Thr Ile Thr Asn Thr Ala Val Thr Ser Leu Glu Trp Val Pro Phe His
            20                  25                  30          
Ala Phe Ala Ile Pro Arg Ser Thr Leu Val Ser Gln Gln Gly Ala Thr
        35                  40                  45              
Ser His Thr Asp Asn Thr Gln Glu Met Asp Ser Pro Gly Gln Glu Pro
    50                  55                  60                  
Gly Phe Ala Lys Glu Val Glu Val Glu Pro Gly Phe Gln Pro Leu Pro
65                  70                  75                  80  
Gln Met Thr Leu Leu Val Pro Ala Met Cys Leu Leu Leu His Gly Ala
                85                  90                  95      
Cys Ser Ala Lys Gly Phe Cys Ala Ala Pro His Phe Leu Leu Ala Ser
            100                 105                 110         
Pro Met Gly Lys Glu Ala Cys Ser Leu Asp Thr Leu Cys Glu His Ser
        115                 120                 125             
Arg Pro Ser Ile Lys Phe Pro His Thr Ala Val Thr Ile Ser His Cys
    130                 135                 140                 
Glu Glu Asp Leu Ile Thr Gly Lys Thr Ile Ser Tyr Arg Glu Lys Pro
145                 150                 155                 160 
Lys Val Gly Glu Glu Leu Asp Leu Pro Gln Ser Leu Lys Arg Asn Pro
                165                 170                 175     
Lys Gly Cys Ile Ala Arg Arg Ala Lys Pro Ile Leu Ala Ala Glu Arg
            180                 185                 190         
His Lys Arg Leu Ile Leu His Thr Ser Thr Lys Glu Asn Thr Leu Leu
        195                 200                 205             
Asp Asn Arg Val Ile Glu Cys Leu Thr Met Glu Ala Val Ala Lys Phe
    210                 215                 220                 
Asn Ile Met Lys Glu Arg Glu Gly Pro Ser His Gln Pro Ala Leu Ser
225                 230                 235                 240 
Pro Pro Lys Ala Arg Trp His Ile Leu Trp Gln Lys Leu Met Phe Thr
                245                 250                 255     
Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr Thr Ala Arg Val Thr
            260                 265                 270         
Thr Glu Ala Met Pro Phe Asn Ala Thr Glu Glu Glu Glu Glu Glu Phe
        275                 280                 285             
Phe Leu Leu Ala His Asn Leu Pro Leu Lys Val Met Gly Tyr Asn Trp
    290                 295                 300                 
His Lys Gly Arg Arg Tyr Ala Thr Gly Ile Gln Arg Ser Ser Ser Gly
305                 310                 315                 320 
Pro Ala Tyr Ser Ser Gln Glu Val Ile Phe Ala Asn Ala Ser Leu Leu
                325                 330                 335     
Thr Arg Lys Val Thr Gln Asp Asp Thr Gly Phe Tyr Thr Leu Gln Ile
            340                 345                 350         
Ile Lys Thr Asp Phe Thr Ile Glu Glu Ala Thr Gly Tyr Phe Arg Val
        355                 360                 365             
His Leu Asn Leu Pro Lys Pro Tyr Val Thr Ser Asn Pro Ala Glu Asp
    370                 375                 380                 
Glu Glu Ala Val Val Leu Thr Cys Glu Pro Glu Thr His Gly Thr Ile
385                 390                 395                 400 
Tyr Met Trp Trp Val Asn Ser His Arg Leu Thr Leu Ser Pro Arg Leu
                405                 410                 415     
Lys Met Ser Asn Asp Asn Arg Val Leu Ala Leu Leu Ser Val Thr Arg
            420                 425                 430         
Ser Asp Thr Gly Leu Tyr Glu Cys Gln Arg Lys Asn Val Val Ser Thr
        435                 440                 445             
Ser His Ser Asp Pro Val Thr Trp Met Phe Ser Ala Asn Leu Asp Gly
    450                 455                 460                 
Pro Asp Glu Pro Thr Thr Tyr Ser Ser Asp Thr Tyr Tyr Tyr Ala Gly
465                 470                 475                 480 
Ser Asn Leu Asn Leu Ser Cys Leu Met Gly Ser Asn Pro Ser Ala Glu
                485                 490                 495     
Tyr Ser Trp Leu Leu Asn Gly Asn Asn Gln Gln Thr Gly Gln Glu Leu
            500                 505                 510         
Phe Ile Pro Gln Val Thr Thr Glu Asn Ser Gly Asp Tyr Leu Cys Tyr
        515                 520                 525             
Val His Asn Pro Val Thr Asn Gly Lys Asn Phe Ala Thr Lys Lys Ile
    530                 535                 540                 
Thr Val Pro Asp Thr Ser Val Gln Gly Ser Ser Pro Gly Leu Ser Gly
545                 550                 555                 560 
Arg Ala Thr Val Ser Ile Leu Ile Glu Val Leu Ala Ser Val Ala Leu
                565                 570                 575     
Ile
    


<210> 2595
<211> 900
<212> PRT
<213> Homo sapiens

<400> 2595
Met Thr Val Ala Ile Arg Arg Pro Gly Val Pro Gly Ala Pro Leu Pro
 1               5                  10                  15      
Gly Arg Ala Ile Leu Ser Met Asn Gly Leu Ser Tyr Gly Val Ile Arg
            20                  25                  30          
Val Asn Thr Glu Asp Lys Asn Ser Ala Leu Thr Val Gln Asp Val Gly
        35                  40                  45              
His Val Met Pro Gly Gly Met Met Cys Ile Val Lys Pro Asp Gly Pro
    50                  55                  60                  
Pro Gln Leu Cys Lys Thr Asp Glu Ile Gly Glu Ile Cys Val Ser Ser
65                  70                  75                  80  
Arg Thr Gly Gly Met Met Tyr Phe Gly Leu Ala Gly Val Thr Lys Asn
                85                  90                  95      
Thr Phe Glu Val Ile Pro Val Asn Ser Ala Gly Ser Pro Val Gly Asp
            100                 105                 110         
Val Pro Phe Ile Arg Ser Gly Leu Leu Gly Phe Val Gly Pro Gly Ser
        115                 120                 125             
Leu Val Phe Val Val Gly Lys Met Asp Gly Leu Leu Met Val Ser Gly
    130                 135                 140                 
Arg Arg His Asn Ala Asp Asp Ile Val Ala Thr Gly Leu Ala Val Glu
145                 150                 155                 160 
Ser Ile Lys Thr Val Tyr Arg Gly Arg Ile Ala Val Phe Ser Val Ser
                165                 170                 175     
Val Phe Tyr Asp Glu Arg Ile Val Val Val Ala Glu Gln Arg Pro Asp
            180                 185                 190         
Ala Ser Glu Glu Asp Ser Phe Gln Trp Met Ser Arg Val Leu Gln Ala
        195                 200                 205             
Ile Asp Ser Ile His Gln Val Gly Val Tyr Cys Leu Ala Leu Val Pro
    210                 215                 220                 
Ala Asn Thr Leu Pro Lys Thr Pro Leu Gly Gly Ile His Ile Ser Gln
225                 230                 235                 240 
Thr Lys Gln Leu Phe Leu Glu Gly Ser Leu His Pro Cys Asn Ile Leu
                245                 250                 255     
Met Cys Pro His Thr Cys Val Thr Asn Leu Pro Lys Pro Arg Gln Lys
            260                 265                 270         
Gln Pro Gly Val Gly Pro Ala Ser Val Met Val Gly Asn Leu Val Ala
        275                 280                 285             
Gly Lys Arg Ile Ala Gln Ala Ala Gly Arg Asp Leu Gly Gln Ile Glu
    290                 295                 300                 
Glu Asn Asp Leu Val Arg Lys His Gln Phe Leu Ala Glu Ile Leu Gln
305                 310                 315                 320 
Trp Arg Ala Gln Ala Thr Pro Asp His Val Leu Phe Met Leu Leu Asn
                325                 330                 335     
Ala Lys Gly Thr Thr Val Cys Thr Ala Ser Cys Leu Gln Leu His Lys
            340                 345                 350         
Arg Ala Glu Arg Ile Ala Ser Val Leu Gly Asp Lys Gly His Leu Asn
        355                 360                 365             
Ala Gly Asp Asn Val Val Leu Leu Tyr Pro Pro Gly Ile Glu Leu Ile
    370                 375                 380                 
Ala Ala Phe Tyr Gly Cys Leu Tyr Ala Gly Cys Ile Pro Val Thr Val
385                 390                 395                 400 
Arg Pro Pro His Ala Gln Asn Leu Thr Ala Thr Leu Pro Thr Val Arg
                405                 410                 415     
Met Ile Val Asp Val Ser Lys Ala Ala Cys Ile Leu Thr Ser Gln Thr
            420                 425                 430         
Leu Met Arg Leu Leu Arg Ser Arg Glu Ala Ala Ala Ala Val Asp Val
        435                 440                 445             
Lys Thr Trp Pro Thr Ile Ile Asp Thr Asp Asp Leu Pro Arg Lys Arg
    450                 455                 460                 
Leu Pro Gln Leu Tyr Lys Pro Pro Thr Pro Glu Met Leu Ala Tyr Leu
465                 470                 475                 480 
Asp Phe Ser Val Ser Thr Thr Gly Met Leu Thr Gly Val Lys Met Ser
                485                 490                 495     
His Ser Ala Val Asn Ala Leu Cys Arg Ala Ile Lys Leu Gln Cys Glu
            500                 505                 510         
Leu Tyr Ser Ser Arg Gln Ile Ala Ile Cys Leu Asp Pro Tyr Cys Gly
        515                 520                 525             
Leu Gly Phe Ala Leu Trp Cys Leu Cys Ser Val Tyr Ser Gly His Gln
    530                 535                 540                 
Ser Val Leu Ile Pro Pro Met Glu Leu Glu Asn Asn Leu Phe Leu Trp
545                 550                 555                 560 
Leu Ser Thr Val Asn Gln Tyr Lys Ile Arg Asp Thr Phe Cys Ser Tyr
                565                 570                 575     
Ser Val Met Glu Leu Cys Thr Lys Gly Leu Gly Asn Gln Val Glu Val
            580                 585                 590         
Leu Lys Thr Arg Gly Ile Asn Leu Ser Cys Val Arg Thr Cys Val Val
        595                 600                 605             
Val Ala Glu Glu Arg Pro Arg Val Ala Leu Gln Gln Ser Phe Ser Lys
    610                 615                 620                 
Leu Phe Lys Asp Ile Gly Leu Ser Pro Arg Ala Val Ser Thr Thr Phe
625                 630                 635                 640 
Gly Ser Arg Val Asn Val Ala Ile Cys Leu Gln Gly Thr Ser Gly Pro
                645                 650                 655     
Asp Pro Thr Thr Val Tyr Val Asp Leu Lys Ser Leu Arg His Asp Arg
            660                 665                 670         
Val Arg Leu Val Glu Arg Gly Ala Pro Gln Ser Leu Leu Leu Ser Glu
        675                 680                 685             
Ser Gly Lys Ile Leu Pro Gly Val Lys Val Val Ile Val Asn Pro Glu
    690                 695                 700                 
Thr Lys Gly Pro Val Gly Asp Ser His Leu Gly Glu Ile Trp Val Asn
705                 710                 715                 720 
Ser Pro His Thr Ala Ser Gly Tyr Tyr Thr Ile Tyr Asp Ser Glu Thr
                725                 730                 735     
Leu Gln Ala Asp His Phe Asn Thr Arg Leu Ser Phe Gly Asp Ala Ala
            740                 745                 750         
Gln Thr Leu Trp Ala Arg Thr Gly Tyr Leu Gly Phe Val Arg Arg Thr
        755                 760                 765             
Glu Leu Thr Ala Ala Thr Gly Glu Arg His Asp Ala Leu Tyr Val Val
    770                 775                 780                 
Gly Ala Leu Asp Glu Thr Leu Glu Leu Arg Gly Leu Arg Tyr His Pro
785                 790                 795                 800 
Ile Asp Ile Glu Thr Ser Val Ser Arg Ile His Arg Ser Ile Ala Glu
                805                 810                 815     
Cys Ala Val Phe Thr Trp Thr Asn Leu Leu Val Val Val Val Glu Leu
            820                 825                 830         
Cys Gly Ser Glu Gln Glu Ala Leu Asp Leu Val Pro Leu Val Thr Asn
        835                 840                 845             
Val Val Leu Glu Glu His Tyr Leu Ile Val Gly Val Val Val Val Val
    850                 855                 860                 
Asp Pro Gly Val Ile Pro Ile Asn Ser Arg Gly Glu Lys Gln Arg Met
865                 870                 875                 880 
His Leu Arg Asp Ser Phe Leu Ala Asp Gln Leu Asp Pro Ile Tyr Val
                885                 890                 895     
Ala Tyr Asn Met
            900 


<210> 2596
<211> 304
<212> PRT
<213> Homo sapiens

<400> 2596
Met Glu His Ser Ser Gly Gln Pro Leu Thr Pro Ser Gln Val Phe Ala
 1               5                  10                  15      
Arg Pro Pro Phe Ile Ser Pro Ala Met Pro Gln Pro Gly Val Phe Ser
            20                  25                  30          
Val Pro Val Gly Asp Gly Ala Ser Gly Ser Trp Ala Val Gly Ser Cys
        35                  40                  45              
Arg Arg His His Gln Val Thr Arg Arg Gly Cys Arg Cys Leu Glu Phe
    50                  55                  60                  
Arg Leu Leu Leu Pro Trp His Gly Leu Gly Lys Leu Ala Ala Leu His
65                  70                  75                  80  
Leu Ile Ala Leu Pro Ala Gly Ile Arg Pro Ser Phe Gln Cys Ser Thr
                85                  90                  95      
Thr Gly Lys Phe Trp Arg Gly Thr Ser Gly Gln Glu His Lys Trp Val
            100                 105                 110         
Lys Glu Phe Ile Ala Val Trp Met Trp Leu Leu Val Leu Ile Ser Ser
        115                 120                 125             
His Asn Leu Met Ser Glu Leu Tyr Ser Pro Pro Ile Gln Thr Asn Lys
    130                 135                 140                 
Gln Phe Asn Pro Ala Ile Gly Ser Gln Lys Glu Gly Ala Phe Glu Gly
145                 150                 155                 160 
Arg Phe Val Leu Glu Gln Phe Ala Ile Asn Ser Leu Ala Pro Pro Cys
                165                 170                 175     
Phe Ser Pro Glu Ile Pro Trp Val Asn Thr His Ile Ser Val Phe Ala
            180                 185                 190         
Glu Arg Lys Glu Pro Leu Gln Ala Ser Leu Ser Ser Leu Asn His Asn
        195                 200                 205             
Gln Tyr Pro Gln Ile Lys Asp Tyr Leu Gln Thr Ala Leu Ile Arg Gln
    210                 215                 220                 
Asn Lys Asn Ser Phe Cys Leu Ser Phe Gly Ala Gln Gln Gln Asn Asn
225                 230                 235                 240 
Lys Val Asp Gln Gln Lys Lys Lys Arg Asn Pro Gly Ala Arg Ser Lys
                245                 250                 255     
Asp Lys Ala Glu Val Gln Ser Thr Gly His Val Cys Tyr Gly Thr Ala
            260                 265                 270         
Ala Ala Leu Asn Met Ser Asn Arg Asp Asn Pro Leu Ser Asp Ala Ser
        275                 280                 285             
Glu Asp Leu Gln Asp Ile Glu Lys Phe Ile Val Val Leu Pro Ser Tyr
    290                 295                 300                 


<210> 2597
<211> 647
<212> PRT
<213> Homo sapiens

<400> 2597
Met Trp Arg Val Cys Ala Arg Arg Ala Gln Asn Val Ala Pro Trp Ala
 1               5                  10                  15      
Gly Leu Glu Ala Arg Trp Thr Ala Leu Gln Glu Val Pro Gly Thr Pro
            20                  25                  30          
Arg Val Thr Ser Arg Ser Gly Pro Ala Pro Ala Arg Arg Asn Ser Val
        35                  40                  45              
Thr Thr Gly Tyr Gly Gly Val Arg Ala Leu Cys Gly Trp Thr Pro Ser
    50                  55                  60                  
Ser Gly Ala Thr Pro Arg Asn Arg Leu Leu Leu Gln Leu Leu Gly Ser
65                  70                  75                  80  
Pro Gly Arg Arg Tyr Tyr Ser Leu Pro Pro His Gln Lys Val Pro Leu
                85                  90                  95      
Pro Ser Leu Ser Pro Thr Met Gln Ala Gly Thr Ile Ala Arg Trp Glu
            100                 105                 110         
Lys Lys Glu Gly Asp Gln Ile Asn Glu Gly Asp Leu Ile Ala Glu Val
        115                 120                 125             
Glu Thr Asp Lys Ala Thr Val Gly Phe Glu Ser Leu Glu Glu Cys Tyr
    130                 135                 140                 
Met Ala Lys Ile Leu Val Ala Glu Gly Thr Arg Asp Val Pro Ile Gly
145                 150                 155                 160 
Ala Ile Ile Cys Ile Thr Val Gly Lys Pro Glu Asp Ile Glu Ala Phe
                165                 170                 175     
Lys Asn Tyr Thr Leu Asp Ser Ser Ala Ala Pro Thr Pro Gln Ala Ala
            180                 185                 190         
Pro Ala Pro Thr Pro Ala Ala Thr Ala Ser Pro Pro Thr Pro Ser Ala
        195                 200                 205             
Gln Ala Pro Gly Ser Ser Tyr Pro Pro His Met Gln Val Leu Leu Pro
    210                 215                 220                 
Ala Leu Ser Pro Thr Met Thr Met Gly Thr Val Gln Arg Trp Glu Lys
225                 230                 235                 240 
Lys Val Gly Glu Lys Leu Ser Glu Gly Asp Leu Leu Ala Glu Ile Glu
                245                 250                 255     
Thr Asp Lys Ala Thr Ile Gly Phe Glu Val Gln Glu Glu Gly Tyr Leu
            260                 265                 270         
Ala Lys Ile Leu Val Pro Glu Gly Thr Arg Asp Val Pro Leu Gly Thr
        275                 280                 285             
Pro Leu Cys Ile Ile Val Glu Lys Glu Ala Asp Ile Ser Ala Phe Ala
    290                 295                 300                 
Asp Tyr Arg Pro Thr Glu Val Thr Asp Leu Lys Pro Gln Ala Pro Pro
305                 310                 315                 320 
Pro Thr Pro Pro Pro Val Ala Ala Val Pro Pro Thr Pro Gln Pro Leu
                325                 330                 335     
Ala Pro Thr Pro Ser Ala Pro Cys Pro Ala Thr Pro Ala Gly Pro Lys
            340                 345                 350         
Gly Arg Val Phe Val Ser Pro Leu Ala Lys Lys Leu Ala Val Glu Lys
        355                 360                 365             
Gly Ile Asp Leu Thr Gln Val Lys Gly Thr Gly Pro Asp Gly Arg Ile
    370                 375                 380                 
Thr Lys Lys Asp Ile Asp Ser Phe Val Pro Ser Lys Val Ala Pro Ala
385                 390                 395                 400 
Pro Ala Ala Val Val Pro Pro Thr Gly Pro Gly Met Ala Pro Val Pro
                405                 410                 415     
Thr Gly Val Phe Thr Asp Ile Pro Ile Ser Asn Ile Arg Arg Val Ile
            420                 425                 430         
Ala Gln Arg Leu Met Gln Ser Lys Gln Thr Ile Pro His Tyr Tyr Leu
        435                 440                 445             
Ser Ile Asp Val Asn Met Gly Glu Val Leu Leu Val Arg Lys Glu Leu
    450                 455                 460                 
Asn Lys Ile Leu Glu Gly Arg Ser Lys Ile Ser Val Asn Asp Phe Ile
465                 470                 475                 480 
Ile Lys Ala Ser Ala Leu Ala Cys Leu Lys Val Pro Glu Ala Asn Ser
                485                 490                 495     
Ser Trp Met Asp Thr Val Ile Arg Gln Asn His Val Val Asp Val Ser
            500                 505                 510         
Val Ala Val Ser Thr Pro Ala Gly Leu Ile Thr Pro Ile Val Phe Asn
        515                 520                 525             
Ala His Ile Lys Gly Val Glu Thr Ile Ala Asn Asp Val Val Ser Leu
    530                 535                 540                 
Ala Thr Lys Ala Arg Glu Gly Lys Leu Gln Pro His Glu Phe Gln Gly
545                 550                 555                 560 
Gly Thr Phe Thr Ile Ser Asn Leu Gly Met Phe Gly Ile Lys Asn Phe
                565                 570                 575     
Ser Ala Ile Ile Asn Pro Pro Gln Ala Cys Ile Leu Ala Ile Gly Ala
            580                 585                 590         
Ser Glu Asp Lys Leu Val Pro Ala Asp Asn Glu Lys Gly Phe Asp Val
        595                 600                 605             
Ala Ser Met Met Ser Val Thr Leu Ser Cys Asp His Arg Val Val Asp
    610                 615                 620                 
Gly Ala Val Gly Ala Gln Trp Leu Ala Glu Phe Arg Lys Tyr Leu Glu
625                 630                 635                 640 
Lys Pro Ile Thr Met Leu Leu
                645         


<210> 2598
<211> 401
<212> PRT
<213> Homo sapiens

<400> 2598
Met Gln Lys Ser Gln Ser Tyr Gly Tyr Gln Asn Glu Lys Glu Glu Glu
 1               5                  10                  15      
Glu Gly Gly Leu Thr Gly Thr Trp Ser Pro Asp Gln Trp Gly Pro Arg
            20                  25                  30          
Pro Trp Glu Val Pro Gly Thr Val Ala Thr Cys Gly Leu Asp Ser Leu
        35                  40                  45              
Cys Leu Trp Gly Val Arg Glu Glu Arg Thr Val Val Trp Gly Val Gly
    50                  55                  60                  
Pro Gln Glu Leu Gln Glu Leu Gly Gly Leu Cys Ile Pro Ile Thr Gln
65                  70                  75                  80  
Leu Leu Pro Thr Leu Pro Leu Ala Ala Leu Thr Arg Val Ile Met Pro
                85                  90                  95      
Leu Gly Gln Arg Ser Gln His Tyr Met Pro Glu Glu Gly Leu Glu Ala
            100                 105                 110         
Gln Gly Glu Val Pro Gly Leu Val Gly Gly Gln Gly Pro Val Pro Glu
        115                 120                 125             
Glu Glu Glu Ala Ala Ser Ser Ser Ser Ser Leu Ile Met Gly Thr Leu
    130                 135                 140                 
Glu Glu Leu Cys Ala Ala Glu Ala Leu Ser Pro Pro Gln Ser Met Gln
145                 150                 155                 160 
Gly Ala Ser Ser Ser Pro Thr Thr Ile Asp Asn Thr Leu Trp Asn Gln
                165                 170                 175     
Ser Asp Glu Gly Ser Ser Ser Gln Glu Lys Glu Glu Pro Ile Thr Leu
            180                 185                 190         
Pro Ile Pro Met Ser Trp Ser Pro Ser Ser Glu Arg His Ser Asp Lys
        195                 200                 205             
Val Ser Asp Leu Val Ser Val Leu Leu His Lys Phe Arg Ile Lys Glu
    210                 215                 220                 
Ser Val Thr Lys Ala Glu Met Val Asp Ser Val Ile Lys Asn His Glu
225                 230                 235                 240 
Asp Tyr Phe Ala Phe Ile Phe Lys Glu Ser Ser Glu Tyr Met Gln Leu
                245                 250                 255     
Ile Phe Gly Ile Asp Val Lys Glu Val Val Pro Thr Gly His Ser Tyr
            260                 265                 270         
Val Leu Val Thr Ser Leu Gly Leu Ser Tyr Asp Gly Met Leu Val Asp
        275                 280                 285             
Asp Pro Ser Lys Pro Lys Thr Gly Leu Leu Ile Ile Val Leu Cys Val
    290                 295                 300                 
Ile Phe Thr Glu Gly Asn Cys Ala Pro Glu Glu Val Met Trp Glu Ala
305                 310                 315                 320 
Leu Asn Val Ile Glu Val Tyr Ala Gly Arg Glu His Phe Ile Tyr Gly
                325                 330                 335     
Glu Pro Arg Lys Leu Leu Thr Arg Asp Trp Val Gln Glu Asn Tyr Leu
            340                 345                 350         
Glu Tyr Trp Gln Val Pro Arg Ser Asp Pro Ala Cys Tyr Glu Glu Glu
        355                 360                 365             
Arg Val Ser Ala Gly Asp Ala Ala Arg Ala Ser Gly Gly Trp Gly Gly
    370                 375                 380                 
Leu Val His Val Pro Gly Leu His Pro Ala Ala Ser Pro Pro Cys Val
385                 390                 395                 400 
Thr
    


<210> 2599
<211> 116
<212> PRT
<213> Homo sapiens

<400> 2599
Met His Lys Cys Phe Phe Phe Phe Glu Ile Trp Glu Phe Pro Pro Phe
 1               5                  10                  15      
Leu Gln Pro Cys Ala Gln Gln Phe Tyr Ile His Gly Asn Tyr Gly Thr
            20                  25                  30          
Pro Ser Leu Ala Glu Ala Ala Cys Ser Leu Lys Asp Glu Ser Lys Gly
        35                  40                  45              
Ala Ser Lys Cys Leu Glu Val Val Ser Gly Ile Asp Met Lys Glu Val
    50                  55                  60                  
Asp Arg Ile Ser His Ser Tyr Val Leu Val Asn Ser Arg Asp Leu Thr
65                  70                  75                  80  
Tyr Asp Glu Met Leu Ala Asp Ser Gln Arg Met Leu Lys Asn Gly Leu
                85                  90                  95      
Leu Ile Ile Val Leu Gly Val Ile Phe Ile Glu Gly Asn Gly Ala Ser
            100                 105                 110         
Gly Glu Asp Ile
        115     


<210> 2600
<211> 126
<212> PRT
<213> Homo sapiens

<400> 2600
Met Pro Ala Val Pro Leu Leu Arg Arg Asn Ile Gly His Thr Glu Gly
 1               5                  10                  15      
Ala Leu Tyr Asn Val Pro Ala Met Leu Lys Arg Leu Val Ile Ile Val
            20                  25                  30          
Lys Glu Pro Met Ser Arg Pro Ala Cys Ser Trp Ser Ser Gln Gly Gln
        35                  40                  45              
Thr Gln Glu Asn Asn Ile Asp Asp Ile Glu Val Lys Gly Lys Tyr Met
    50                  55                  60                  
Gly Leu Ala Ile Trp Asp Thr Val Gly Gln Glu Gly Gln Arg Thr Leu
65                  70                  75                  80  
Glu Ser Lys Arg Phe Cys Pro Asn Val Tyr Ser Ile Leu Val Gly Asn
                85                  90                  95      
Lys Met His Leu Leu Lys Asp Gly His Ile Arg Gln Asp Leu Thr Lys
            100                 105                 110         
Thr Lys Gln Glu Leu Val Lys Leu Asp Gly Cys Leu Glu Ile
        115                 120                 125     


<210> 2601
<211> 488
<212> PRT
<213> Homo sapiens

<400> 2601
Met Thr Val Ala Met Val Gln Ile Glu Asn Arg Ile Ile Trp Arg Thr
 1               5                  10                  15      
Asp Lys Ser Val Gln Arg Arg Ala Ile Gly Phe Met Val Pro Ala Leu
            20                  25                  30          
Phe Asn Pro Asp Val Thr Trp Asp Arg Lys Asn Asp Pro Glu Pro Trp
        35                  40                  45              
Asn Lys Leu Gly Pro Asn Asp Gln Tyr Lys Leu Tyr Ser Ala Pro Pro
    50                  55                  60                  
Pro Cys Arg Arg Ser Cys Thr Cys Arg Pro Ala Ser Val Ala Ala Arg
65                  70                  75                  80  
Ser Gly Pro Ser Phe Gly Arg Leu Ser Val Thr Asn Met Gly Ile Asp
                85                  90                  95      
Pro Thr Gly Thr Tyr Tyr Arg Asp Ser Asp Leu Gln Pro Glu Arg Ile
            100                 105                 110         
Asn Val Tyr Tyr Asn Glu Ala Arg Gly Gly Asn Tyr Val Pro Arg Ala
        115                 120                 125             
Val Leu Val Asp Leu Glu Pro Ser Thr Met Asp Ser Ile Leu Ser Gly
    130                 135                 140                 
Pro Phe Gly Gln Ile Phe Arg Pro Asp Asn Phe Val Phe Gly Gln Ser
145                 150                 155                 160 
Arg Ala Gly Asn Asn Trp Val Lys Gly His Tyr Thr Glu Gly Thr Glu
                165                 170                 175     
Leu His Gly Ala Leu Ala Gln Ser Val Arg Tyr Gly Val Glu Pro Tyr
            180                 185                 190         
Asn Ala Thr Leu Ser Val His Gln Leu Val Glu Asn Thr Asn Glu Thr
        195                 200                 205             
Tyr Cys Ile Asn Asn Gly Ala Leu Tyr Asp Ile Cys Phe Arg Thr Leu
    210                 215                 220                 
Lys Leu Thr Thr Ser Thr Tyr Gly Asp Leu Asn His Leu Val Ser Ala
225                 230                 235                 240 
Thr Met Ser Arg Val Thr Thr Cys Leu Cys Phe Leu Gly Gln Leu Asn
                245                 250                 255     
Thr Asn Leu His Lys Leu Ala Val Asn Met Val Pro Phe Pro Cys Pro
            260                 265                 270         
His Phe Phe Met Pro Gly Phe Ala Pro Leu Thr Ser Arg Gly Ser Gln
        275                 280                 285             
Gln Tyr Gln Ala Leu Arg Glu Val Asp Lys Gln Met Leu Ser Leu Gln
    290                 295                 300                 
Ser Lys Asn Ser Ser Tyr Phe Val Gln Trp Ile Pro Asn Asn Met Lys
305                 310                 315                 320 
Thr Ala Val Cys Asp Ile Ser Pro His Gly Leu Lys Ile Ala Ala Thr
                325                 330                 335     
Phe Ile Ser Asn Asn Thr Asp Phe Gln Glu Leu Phe Lys Cys Ile Ser
            340                 345                 350         
Ala Gln Phe Thr Ala Met Leu Trp Cys Lys Ala Phe Leu His Trp Tyr
        355                 360                 365             
Thr Gly Glu Gly Met Asp Glu Met Glu Phe Thr Glu Thr Asp Ser Asn
    370                 375                 380                 
Met Asn Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala
385                 390                 395                 400 
Glu Glu Gly Glu Phe Lys Gln Glu Ala Glu Glu Glu Glu Glu Pro Arg
                405                 410                 415     
Phe Thr Pro Ser Asp Ser Gly Asn His Thr Phe Asn Phe Glu Gly Pro
            420                 425                 430         
Leu Ser Pro Leu Thr Ser Ala Ser Pro Leu Thr Pro Ala Pro His Glu
        435                 440                 445             
Ser His Phe Thr Ser Arg Pro Ile Ser Pro Gly Leu Cys Leu Thr Pro
    450                 455                 460                 
Pro Ser Glu Leu His Phe Thr Ser Asp Leu Ala Ser Pro Leu Thr Pro
465                 470                 475                 480 
Asp Leu Ser Pro Ser Ser Tyr Leu
                485             


<210> 2602
<211> 115
<212> PRT
<213> Homo sapiens

<400> 2602
Met Gln Pro Ile Cys Cys Arg His Cys Ala Gln Cys Met Pro Lys Asp
 1               5                  10                  15      
Lys Ala Thr Lys Lys Phe Val Ile Gln Asn Arg Arg Gly Cys Ser Tyr
            20                  25                  30          
Gln Thr Phe Pro Lys Gly Val Ser Ser Thr Pro Ala Cys Phe Pro Arg
        35                  40                  45              
Thr Gly Asp Phe Gln Leu His Ile Asn Val Asn Asp Gly Thr Glu Tyr
    50                  55                  60                  
Gly Glu Ser Ile Tyr Gln Lys Val Cys Glu Asn Leu Asp Thr Ser Val
65                  70                  75                  80  
His Cys Thr Trp Thr Ser Gly Thr Asn Cys Thr His Phe Arg Ile Val
                85                  90                  95      
Ala Lys Tyr Arg Leu Asp Pro Thr Ala Ser Ile Ser Ala Lys Val Asn
            100                 105                 110         
Asn Ser Ser
        115 


<210> 2603
<211> 215
<212> PRT
<213> Homo sapiens

<400> 2603
Met Trp Gly Ser Ala Phe Lys Gly Glu Lys Met Leu His Leu Gly Asp
 1               5                  10                  15      
Phe Ser Gln Ser Val Glu Ser Lys Trp Arg Val Ser Pro Val Ala Glu
            20                  25                  30          
Ser Pro Thr Ala Val Val Ala Ile Ala Glu Ala Ile Ala His Trp Arg
        35                  40                  45              
Val Gly Ala Ala Ile Ala Thr Ala Asn Ala Ile Ser Gln Arg Val Ala
    50                  55                  60                  
Ile Ala Ala Pro Val Ala Ser Trp Glu Asp Ser Pro Gly Glu Val Val
65                  70                  75                  80  
Ala Glu His Gly Val Gly Ser Gly Gly Leu Ser Ile Lys Asp Lys Asp
                85                  90                  95      
His Ser Lys Lys Ser Ala Arg Arg Trp Lys Met Tyr His Pro Ser Thr
            100                 105                 110         
Trp Glu Gly Arg Lys Thr Val Ile Ala Leu Gln Val Val Leu Cys Arg
        115                 120                 125             
Glu Leu Ile Glu Ser Pro Val Val Thr Gly Ala Ile Gly Pro Ser Val
    130                 135                 140                 
Gly Ala Val Ala Lys Ala Arg Ala Arg Ala Pro Trp Pro Ile Glu Ala
145                 150                 155                 160 
Thr Thr Ile Ala Ala Ala Gln Val Val Asp Val Ala Thr Thr Lys Ala
                165                 170                 175     
Val Ala Gln Gly Ala Val Ala Ile Ala Ser Thr Ala Ile Val Gln Gly
            180                 185                 190         
Arg Ala Gln Arg His Asn Thr Val Gln Gly Gly Gly Ser Glu Gly Pro
        195                 200                 205             
Met Glu Val Gly Pro Ile Glu
    210                 215 


<210> 2604
<211> 793
<212> PRT
<213> Homo sapiens

<400> 2604
Met Ala Asp Ile Glu Met Thr Leu Ser Thr Gln Gly Ala Lys Leu Gln
 1               5                  10                  15      
Glu Thr Glu Ala Leu Ser Asp Leu Gln Val Asn Thr Arg Ser Cys Ser
            20                  25                  30          
Gly Arg Gln Pro Asp Pro Gly Ala Cys Arg Ser Leu Ser Pro Thr Gln
        35                  40                  45              
Met Val Ser Gln Met Trp Ala Phe Ser Cys Ser Thr Cys Lys Arg Asn
    50                  55                  60                  
Ser Pro Asn Arg Ala Pro Ala Ala Phe Arg Ala Lys Ser Val Glu Arg
65                  70                  75                  80  
Thr Glu Gly Arg Leu Thr Ala Arg Lys Ala Gly Leu Cys Arg Ala Glu
                85                  90                  95      
Gly Met Gly Pro Arg Ser Leu Ser Thr Ser Val Gly Leu Trp Leu Lys
            100                 105                 110         
Ser Gly Ser Thr Ser Ala Leu Arg Pro Ala Asn Arg Ile Pro Gln Thr
        115                 120                 125             
Val Leu Glu Gly Asn Lys Val Trp Leu Pro Gln Thr Gln Asn Ile Leu
    130                 135                 140                 
Ala Thr Leu Leu His Pro Leu Ile Phe Gln Val His Leu His Lys Cys
145                 150                 155                 160 
Ala Arg Asp Glu Gly Asp Lys Asp Gln Val Thr Ser Thr Thr Pro Asp
                165                 170                 175     
Pro Pro Asp Ser Ser Pro Asp Thr Gln Pro Glu Lys Leu Met Gly Asn
            180                 185                 190         
Gly Cys Phe Gly Ile Thr Glu Gly Cys Gly Arg Gln His Pro Gly Gly
        195                 200                 205             
Phe Cys Leu Pro Cys Gly Ala Ala Ala Glu Ser His Thr His Glu Leu
    210                 215                 220                 
Met Thr Phe Tyr Gly Lys Tyr Val His Pro Leu Ser Arg Leu His Gly
225                 230                 235                 240 
Ile Arg Ile His Arg Leu Asp Ser Arg Phe His Gly Met His Ile Arg
                245                 250                 255     
Pro Leu Ser Arg Phe His Asp Val Asn Val Pro Leu Leu Ser Arg Leu
            260                 265                 270         
Cys Ala Ala Val Ala Ser Val Gly Ala Gly Gln Val Ala Trp Gly Ala
        275                 280                 285             
Gly Leu Thr Glu Arg Leu Ala Pro Pro Ser Gly Glu Gly Val Ser Arg
    290                 295                 300                 
Thr Ile Leu Leu His Glu Ala Lys Pro Leu Ala Pro Arg His Ser Lys
305                 310                 315                 320 
Lys Ser Ala Lys Ile Ile Glu Lys Lys Arg Gly Lys Lys Lys His Thr
                325                 330                 335     
Glu Thr Pro Lys Ser Gly Ser Gly Ser Gly Leu Asp Val Gly Arg Thr
            340                 345                 350         
Leu Ile Leu Pro Ala Leu Val Gln Asn Gln Thr Gly Phe Gln Val Glu
        355                 360                 365             
Gly Ala Arg Gly Pro Asp Pro Gly Gly Asp Gln Gln Pro Gly His Ile
    370                 375                 380                 
Val Pro Asp Gln Thr Thr Ser Val Glu Leu Ala Val Cys Phe Tyr Val
385                 390                 395                 400 
Ser Leu Ser Pro Lys Ser Ser Lys His Phe Ser Gln Ile Leu Ala Phe
                405                 410                 415     
Ser His Ile Thr Phe Leu Glu Ser Lys Glu Gly Arg Gly Arg Ser Gln
            420                 425                 430         
Glu Leu Thr Ala Glu Glu Asp Leu Gln Leu Leu Val Gln Ile Val Asp
        435                 440                 445             
Gly Ala Ser Leu Ala Leu Lys Met Leu Lys Glu Ile Glu Ser Glu His
    450                 455                 460                 
Pro Asn Trp Leu Glu Thr Trp Lys Val Ser Phe Gly Lys Leu Gly Pro
465                 470                 475                 480 
Pro Leu Lys Leu Glu Leu Leu Ser Val Asn Ala Gln Asn Leu Leu Ala
                485                 490                 495     
Lys Leu Trp Leu Asn Arg Arg Leu Leu Pro Gly Val Leu Ile Lys Asn
            500                 505                 510         
Gly Val Gly Gly Val Val Ile Phe Ser Ala Lys Gly Ala Asp Gln Thr
        515                 520                 525             
His Gln Gly Leu Ile Val Thr Leu Leu His Val Pro Trp Ile Leu Gly
    530                 535                 540                 
Gly Leu Val Asp Tyr Val Cys His Leu Ser Lys Glu Pro Ile Asp Glu
545                 550                 555                 560 
Glu Leu Trp Ala Val Gly Leu Arg Gln Gln Asn Lys Glu Arg Ser Thr
                565                 570                 575     
Gly His Ser Gly Cys Asp Val His Phe His Gln Glu Val Val Leu Ser
            580                 585                 590         
Arg Asp Gln Val Trp Ala Arg Arg Arg Glu Thr Val Asp Leu Lys Ala
        595                 600                 605             
Cys Ser Gly Asp Leu Leu Glu Arg Ile Asn Ile Lys Thr Ser Leu Lys
    610                 615                 620                 
Asn Leu Pro Asp Thr Ala Phe Gln Thr His Leu Phe Ser Pro Arg Ile
625                 630                 635                 640 
Ile Ser Leu Thr Leu Thr Thr His Phe Ile Arg Arg Ile Asn Arg Lys
                645                 650                 655     
Leu Thr Ser Arg Cys Tyr Lys Arg Asn Leu Ser Ile Gln Arg Val Leu
            660                 665                 670         
Glu Pro Gly Ser Val Ala Ser Val Leu Cys Val Asp His Trp Gly Val
        675                 680                 685             
Gly Arg Ala Thr Gly Thr Gly Arg Ser Ser Phe Gly Gln Ala Val Ala
    690                 695                 700                 
Leu Glu Ala Asn Gly Val Met Lys Arg Ser Leu Asp Ala Leu Thr Leu
705                 710                 715                 720 
Lys Met Leu Ser Lys His Glu Ser Val His Gln Arg Val Asp Leu Thr
                725                 730                 735     
Pro Ile Arg Asn Ile Pro Gly Val Arg Trp Cys Glu Gly Ala Arg Arg
            740                 745                 750         
Val Gly Glu Ala Ser Arg Ser Pro Ala Arg Arg Met Gly Thr Ala Glu
        755                 760                 765             
Ile Thr Gly Ser Ala Gln Ser Arg Ile Gln Asp Pro Lys Ile Thr Ala
    770                 775                 780                 
Ala Pro Glu Glu Tyr Leu Thr Thr Val
785                 790             


<210> 2605
<211> 466
<212> PRT
<213> Homo sapiens

<400> 2605
Met Ala Ser Leu Leu Arg Arg Gln Pro Ala Gly Pro Val Cys Gly Lys
 1               5                  10                  15      
Met Pro Ser Val Leu Leu Arg Asn Gly Leu Leu Cys Ser Ala Ser Phe
            20                  25                  30          
Ala Leu Glu Ala Ser Gln Leu Gly Ser Arg Thr Ala Thr Cys Arg Ser
        35                  40                  45              
Phe Arg Gln Gln Gly Pro Lys Arg Lys Lys Pro Val Leu Asn Gln Lys
    50                  55                  60                  
Ser Glu Ile Glu Val Glu Glu Pro Arg His Trp Leu Pro Gly Leu Asp
65                  70                  75                  80  
Pro Pro Arg Gly Ser Pro Gln Gly Met His Asn Thr Gly Ser Cys His
                85                  90                  95      
Pro Gln Pro Leu Leu Asp Thr Ala Val Arg Ala Ile Trp Gly Gln Val
            100                 105                 110         
Thr Leu Ser Trp Ser Thr Leu Ser Ser Trp Asp Cys Glu Leu Pro Pro
        115                 120                 125             
Lys Ile Trp Glu Val Ser Gln Lys Ile Leu Ala Arg Ala Ala His Arg
    130                 135                 140                 
His Thr Asp Thr Arg Asn Glu Ser Ser Glu Ser His Met Gly Ala Gly
145                 150                 155                 160 
Leu His Asn Gly Arg Pro Gly Ala Pro Phe Arg Pro His Gln Thr Gly
                165                 170                 175     
Ala Thr Met Glu Ile Ser Ala Ala Leu Glu Leu Val Leu Leu Leu Thr
            180                 185                 190         
Ser Met Ala Leu Val Ala Phe Met Glu Thr Ala Ile Val Cys Lys Gly
        195                 200                 205             
Arg Lys Val Ala Gly Ser Tyr Gly Ser Gln Gly Thr Val Thr Val Arg
    210                 215                 220                 
Asp His Trp Asp Arg Arg Thr Asp Ser His Ser Asp Gln Ile Trp Ala
225                 230                 235                 240 
Pro Arg Phe Val Ser Arg Gly Pro Glu Ala Ala His Ser Leu Pro Glu
                245                 250                 255     
Leu Pro Cys Leu Arg Ala Pro Gln Pro Ala Leu Pro Gln Glu Glu Gly
            260                 265                 270         
Gln Cys Phe Leu Leu Pro Val Gly Ile Gly Gly Pro Ser Gly Thr Gly
        275                 280                 285             
Pro Ala Ala Ala Trp Arg Pro Asp Val Ser Ile Pro Thr Met Ala Val
    290                 295                 300                 
Ser Arg Gly Cys Val Glu Gly Gln Ser Cys Trp Gly Leu Gly Lys Thr
305                 310                 315                 320 
Arg Asp Arg Leu Pro Pro Val Thr Ala Gly Leu Ala Val Gly Phe Trp
                325                 330                 335     
Leu Arg Lys Arg Thr Ser His Trp Phe Pro Gln Ser Val His Pro Asp
            340                 345                 350         
Ser Gly Leu Ser Thr Gly Thr Trp Phe Asn Val Ser Trp Leu Lys Pro
        355                 360                 365             
Trp Trp Cys Gln Gly Leu Lys Ala Leu Ser Pro Glu Gly Ser Pro Val
    370                 375                 380                 
Gly Ser Asp Leu Leu Ser Ser Val Gly Tyr Tyr Ser Phe Asp Val Phe
385                 390                 395                 400 
Arg His Trp His Arg Gly Phe Leu Thr Ser Val Phe Val Ala Ser Trp
                405                 410                 415     
Ser Gly Gly Lys His Pro Lys Leu Arg Phe Thr Asp Glu Lys Ala Glu
            420                 425                 430         
Arg Leu Ile Lys Pro Phe Val Val Pro Arg Arg Val Ser Phe Gly Ala
        435                 440                 445             
Gly Ser His His Arg Thr Trp Leu Pro Thr Thr Pro Ala Glu Pro Gly
    450                 455                 460                 
Ser Ser
465     


<210> 2606
<211> 596
<212> PRT
<213> Homo sapiens

<400> 2606
Met Ala Met Asn Phe Gly Asp His Ala Ser Gly Phe Arg His Asp Asp
 1               5                  10                  15      
Val Ile Arg Phe Ile Asn Asn Glu Val Leu Arg Asn Gly Gly Ser Pro
            20                  25                  30          
Ala Phe Tyr Thr Ala Phe Arg Ser Arg Pro Trp Asn Glu Val Glu Asp
        35                  40                  45              
Arg Leu Arg Ala Ile Val Ala Asp Pro Arg Val Pro Arg Ala Ile Lys
    50                  55                  60                  
Arg Ala Cys Thr Trp Ser Ala Leu Ala Leu Ser Val Gln Val Ala Ala
65                  70                  75                  80  
Arg Gln Gln Glu Glu Leu Leu Tyr Gln Val Trp Trp Leu Gln Gly His
                85                  90                  95      
Val Glu Glu Cys Gln Ala Thr Ser Trp Ala Leu Thr Ser Gln Leu Gln
            100                 105                 110         
Gln Leu Arg Leu Glu His Glu Glu Val Ala Thr Gln Leu His Leu Thr
        115                 120                 125             
Gln Ala Ala Leu Gln Gln Val Leu Asn Glu Arg Asp Gly Leu Cys Gly
    130                 135                 140                 
Arg Leu Leu Glu Val Glu Arg Ser Met Gln Val Tyr Pro Met Pro Gln
145                 150                 155                 160 
Asp Phe Val Pro Gly Pro Glu Ala Gly Gln Tyr Gly Pro Val Ala Gly
                165                 170                 175     
Thr Leu Asn Ala Glu Gln Ser Glu Ala Val Ala Thr Glu Ala Gln Gly
            180                 185                 190         
Met Pro His Ser Glu Ala Gln Val Ala Ala Pro Thr Ala Val Tyr Tyr
        195                 200                 205             
Met Pro Glu Pro Gln Ser Gly Arg Val Gln Gly Met Gln Pro Leu Leu
    210                 215                 220                 
Leu Met Gln Ala Pro His Pro Val Pro Phe His Met Pro Ser Pro Met
225                 230                 235                 240 
Gly Leu Pro Tyr Ser Thr Pro Leu Pro Pro Pro Val Val Met Glu Ser
                245                 250                 255     
Ala Ala Ala Ile Ala Pro Gln Met Pro Pro Ala Gly Ile Tyr Pro Pro
            260                 265                 270         
Gly Leu Trp Ala Thr Val Gly Ser Gln Glu Glu Thr Ala Pro Pro Trp
        275                 280                 285             
Asp Gln Lys Cys His Gly Gln Asp Gly Tyr Pro Glu Asn Phe Gln Gly
    290                 295                 300                 
Val Tyr His Pro Gly Asp Asn Arg Ser Cys Asn Gln Lys Glu Gly Ser
305                 310                 315                 320 
Glu Cys Pro Gln Gly Met Thr Ser Gln Gly Asp Ser Ser Ser His Ser
                325                 330                 335     
Leu Lys Lys Asp Pro Val Met Gln Glu Gly Thr Ala Pro Pro Glu Phe
            340                 345                 350         
Ser Arg Ser His Ser Leu Glu Lys Lys Pro Val Met Pro Lys Glu Met
        355                 360                 365             
Val Pro Leu Gly Asp Ser Asn Ser His Ser Leu Lys Lys Asp Pro Val
    370                 375                 380                 
Val Pro Lys Glu Ile Val Pro Ile Gly Asp Ser Asn Ser His Ser Leu
385                 390                 395                 400 
Thr Lys Asn Pro Val Val His Lys Glu Met Val Ser Leu Gly Asp Ser
                405                 410                 415     
Asn Ser His Ser Met Lys Lys Asp Pro Val Met Pro Gln Lys Met Val
            420                 425                 430         
Pro Leu Gly Asp Ser Asn Ser His Ser Leu Lys Lys Asp Pro Met Met
        435                 440                 445             
Cys Gln Glu Met Val Pro Leu Gly Asp Ser Asn Ser His Ser Leu Lys
    450                 455                 460                 
Lys Asp Pro Val Glu Ala Gln Pro Glu Glu Ser Ala Asn Asp Ala Gln
465                 470                 475                 480 
Gly Asp Gly Pro Pro Gly Gly Lys Pro Gln Pro Gln Pro Glu Glu Arg
                485                 490                 495     
Ser Ser Cys Ala Gln Gly Ala Gly Pro Pro Gly Gly Gln Gln Glu Ser
            500                 505                 510         
Gln Asp Glu Glu Arg Ser Ser Asp Ala Pro Glu Asp Gly Pro Pro Gly
        515                 520                 525             
Gly Gln Gln Lys Pro Gln Pro Glu Glu Arg Ser Ser Asp Ala Pro Glu
    530                 535                 540                 
His Asp Pro Pro Gly Gly Gln Gln Gln Pro Gln Pro Glu Glu Arg Ser
545                 550                 555                 560 
Ser Asp Ala Pro Glu His Asp Pro Pro Gly Gly Gln Gln Gln Pro Gln
                565                 570                 575     
Ser Glu Glu Arg Ser Asn Asp Ala Pro Gly Asp Gly Pro Pro Gly Gly
            580                 585                 590         
Gln Gln Gln Pro
        595     


<210> 2607
<211> 327
<212> PRT
<213> Homo sapiens

<400> 2607
Met His Pro Lys Glu Glu Pro Pro Leu Gly Gly Ala Ser Leu Thr Leu
 1               5                  10                  15      
Pro Val Leu Ala Gly Arg Lys Leu Glu Gly Pro Gly Leu Gly Ser Ala
            20                  25                  30          
Ala Ser His Asp Leu Glu Leu Gln Tyr Ser Arg Gly Asn Arg Thr Pro
        35                  40                  45              
Thr Pro Val Cys Met Thr Ala Thr Glu His Gln Gln Glu Val Thr Arg
    50                  55                  60                  
Ala Gly Lys Gly Ala Glu Thr Gly Cys Asn Met Ser Arg Ala Val Ser
65                  70                  75                  80  
Ile Thr Arg Glu Asp Arg Arg Val Pro Trp Arg Ser Gln Asn Lys Asn
                85                  90                  95      
Gln Gly Asp Arg Pro Ser Gln Gly Leu Trp Glu Asn Ser Ser Gln Ala
            100                 105                 110         
Glu Val Pro Thr Leu Arg Asp Ile Leu Leu Gly Leu Ala Leu Leu Ser
        115                 120                 125             
Val Gly Asp Lys Val Pro Arg Gln Gln Ser Asp Glu Ile Lys Trp Gly
    130                 135                 140                 
Pro Trp Gly Gln Asp His Pro Ser Val Gln Val Leu Gly Gly Asn Ala
145                 150                 155                 160 
Thr Phe Ala Ala Thr Glu Arg Gln Glu Arg Ala Phe Leu Arg Thr Thr
                165                 170                 175     
Pro Gln Lys Asp Arg Pro Lys Val Lys Thr Val Ile His Thr Gln Glu
            180                 185                 190         
Val Ser Glu Thr Ile Phe Met Trp Leu Lys Leu Ala Asn Thr Thr Thr
        195                 200                 205             
Gln Val Thr Pro Glu Ser His Cys Asp Phe Arg Ser Arg Met Pro Gly
    210                 215                 220                 
Ala Trp Thr His Gln Gln Asp Ser Arg Asp Trp Gly Ser Ser Ser Pro
225                 230                 235                 240 
Gly Arg Gln Pro Pro Pro Leu Glu Ala His Asn Thr Thr Asp Glu Glu
                245                 250                 255     
Glu Lys His His Arg Cys Leu Lys Asp Val Gln Cys Gln Asp Ala Pro
            260                 265                 270         
Lys Ala Pro Ala Leu Arg Ser Arg Arg Pro Ser Ser Gln Arg Gly His
        275                 280                 285             
Asn Thr Ser Pro Gly Gly Pro Ala Trp Gly Pro Trp Gly His Asp Ala
    290                 295                 300                 
Pro Pro Ala Pro Ala Ser Leu Arg Ala Ser Pro Pro His Glu Gly Glu
305                 310                 315                 320 
Glu His Pro Lys His Thr Ile
                325         


<210> 2608
<211> 263
<212> PRT
<213> Homo sapiens

<400> 2608
Met Gly Lys Leu Thr Thr Met Pro Ala Gly Leu Ile Tyr Ala Ser Val
 1               5                  10                  15      
Ser Val His Ala Ala Lys Gln Glu Glu Ser Lys Lys Gln Leu Val Lys
            20                  25                  30          
Pro Glu Gln Leu Pro Ile Tyr Thr Ala Pro Pro Leu Gln Ser Lys Tyr
        35                  40                  45              
Val Glu Glu Gln Pro Gly His Leu Gln Met Gly Phe Ala Ser Ile Arg
    50                  55                  60                  
Thr Ala Thr Gly Cys Tyr Ile Gly Trp Cys Lys Gly Val Tyr Val Phe
65                  70                  75                  80  
Val Lys Asn Gly Ile Met Asp Thr Val Gln Phe Gly Lys Asp Ala Tyr
                85                  90                  95      
Val Tyr Leu Lys Asn Pro Pro Arg Asp Phe Leu Pro Lys Met Gly Val
            100                 105                 110         
Ile Thr Val Ser Gly Leu Ala Gly Leu Val Ser Ala Arg Lys Gly Ser
        115                 120                 125             
Lys Phe Lys Lys Ile Thr Tyr Pro Leu Gly Leu Ala Thr Leu Gly Ala
    130                 135                 140                 
Thr Val Cys Tyr Pro Val Gln Ser Val Ile Ile Ala Lys Val Thr Ala
145                 150                 155                 160 
Lys Lys Val Tyr Ala Thr Ser Gln Gln Ile Phe Gly Ala Val Lys Ser
                165                 170                 175     
Leu Trp Thr Lys Ser Ser Lys Glu Glu Ser Leu Pro Lys Pro Lys Glu
            180                 185                 190         
Lys Thr Lys Leu Gly Ser Ser Ser Glu Ile Glu Val Pro Ala Lys Thr
        195                 200                 205             
Thr His Val Leu Lys His Ser Val Pro Leu Pro Thr Glu Leu Ser Ser
    210                 215                 220                 
Glu Ala Lys Thr Lys Ser Glu Ser Thr Ser Gly Ala Thr Gln Phe Met
225                 230                 235                 240 
Pro Asp Pro Lys Leu Met Asp His Gly Gln Ser His Pro Glu Asp Ile
                245                 250                 255     
Asp Met Tyr Ser Thr Arg Ser
            260             


<210> 2609
<211> 197
<212> PRT
<213> Homo sapiens

<400> 2609
Met Arg Leu Val Val Gln Ala Glu Val Ile Leu Ser Ala Ser Cys Leu
 1               5                  10                  15      
Glu Pro Leu Lys Leu Trp Ala Asn Ser Lys Lys Phe Lys Leu His Leu
            20                  25                  30          
His Thr Leu Arg Ser Ile Gln Arg Pro Arg Lys Lys His Lys Asp Pro
        35                  40                  45              
Ala Glu Ser Ser Glu Ala Gln Ala Lys Tyr Met Arg Gln Gly Ala Arg
    50                  55                  60                  
Glu Cys Gly Gly Ser Glu Phe Ser Thr Met Ala Thr Asp Ser Asp Thr
65                  70                  75                  80  
Ala Gln Phe Gly Pro Met Thr Arg Cys Arg Asp Phe His His Thr Lys
                85                  90                  95      
Glu Met Ala Asn Pro Asn Trp Ile Gln Gly Ser Arg Asp Trp Leu Ile
            100                 105                 110         
Tyr Asn Ala Arg Gly Gly Gly Gly Ile Ser Val Thr Arg Lys Cys Cys
        115                 120                 125             
Leu Ala Val Gln Gly Lys Gly Ala Arg Leu Pro Asn Leu Arg Val Leu
    130                 135                 140                 
Val Tyr Ser Asp Lys Met Arg Lys Thr Ala Lys Ala Val Gln Lys Ser
145                 150                 155                 160 
Val Cys Val Met Ala Ala Asn Thr Ser Ala Cys Thr Lys Leu Pro Val
                165                 170                 175     
Ser Phe Pro Lys Thr Pro Ala Leu Gly Arg Thr Thr Phe Ala Phe Ser
            180                 185                 190         
Arg Phe Pro Ile Asn
        195         


<210> 2610
<211> 590
<212> PRT
<213> Homo sapiens

<400> 2610
Met Asp Lys His Asn Phe Ala Gly Arg Ser Gly Ser Ile Tyr Glu Met
 1               5                  10                  15      
Phe Gly Asn Glu Cys Cys Phe Ser Thr Gly Glu Val Ile Lys Ile Thr
            20                  25                  30          
Gly Leu Lys Val Lys Lys Ile Ile Ala Glu Ile Cys Glu Gln Ile Glu
        35                  40                  45              
Gly Cys Glu Ser Leu Gln Pro Phe Glu Leu Pro Met Asn Phe Pro Gly
    50                  55                  60                  
Thr Phe Val Lys Arg Ser Lys Glu Cys Leu Phe Lys Ile Val Ala Asp
65                  70                  75                  80  
Lys Thr Pro Tyr Leu Thr Met Glu Glu Ile Thr Arg Thr Ile His Ile
                85                  90                  95      
Gly Pro Ser Arg Leu Gly His Pro Cys Phe Tyr His Gln Lys Asp Ile
            100                 105                 110         
Lys Leu Glu Asn Leu Ile Ile Lys Gln Gly Glu Gln Ile Met Leu Asn
        115                 120                 125             
Ser Val Glu Glu Ile Asp Gly Glu Ile Met Val Ser Cys Ala Val Ala
    130                 135                 140                 
Arg Asn His Gln Thr His Ser Phe Asn Leu Pro Leu Ser Gln Glu Gly
145                 150                 155                 160 
Glu Phe Tyr Glu Cys Glu Asp Glu Arg Ile Tyr Thr Leu Lys Glu Ile
                165                 170                 175     
Val Glu Trp Lys Ile Pro Lys Asn Arg Thr Arg Thr Val Asn Leu Thr
            180                 185                 190         
Asp Phe Ser Asn Lys Trp Asp Ser Thr Asn Pro Phe Pro Lys Asp Phe
        195                 200                 205             
Tyr Gly Thr Leu Ile Leu Lys Pro Val Tyr Glu Ile Gln Gly Val Met
    210                 215                 220                 
Lys Phe Arg Lys Asp Ile Ile Arg Ile Leu Pro Ser Leu Asp Val Glu
225                 230                 235                 240 
Val Lys Asp Ile Thr Asp Ser Tyr Asp Ala Asn Trp Phe Leu Gln Leu
                245                 250                 255     
Leu Ser Thr Glu Asp Leu Phe Glu Met Thr Ser Lys Glu Phe Pro Ile
            260                 265                 270         
Val Thr Glu Val Ile Glu Ala Pro Glu Gly Asn His Leu Pro Gln Ser
        275                 280                 285             
Ile Leu Gln Pro Gly Lys Thr Ile Val Ile His Lys Lys Tyr Gln Ala
    290                 295                 300                 
Ser Arg Ile Leu Ala Ser Glu Ile Arg Ser Asn Phe Pro Lys Arg His
305                 310                 315                 320 
Phe Leu Ile Pro Thr Ser Tyr Lys Gly Lys Phe Lys Arg Arg Pro Arg
                325                 330                 335     
Glu Phe Pro Thr Ala Tyr Asp Leu Glu Ile Ala Lys Ser Glu Lys Glu
            340                 345                 350         
Pro Leu His Val Val Ala Thr Lys Ala Phe His Ser Pro His Asp Lys
        355                 360                 365             
Leu Ser Ser Val Ser Val Gly Asp Gln Phe Leu Val His Gln Ser Glu
    370                 375                 380                 
Thr Thr Glu Val Leu Cys Glu Gly Ile Lys Lys Val Val Asn Val Leu
385                 390                 395                 400 
Ala Cys Glu Lys Ile Leu Lys Lys Ser Tyr Glu Ala Ala Leu Leu Pro
                405                 410                 415     
Leu Tyr Met Glu Gly Gly Phe Val Glu Val Ile His Asp Lys Lys Gln
            420                 425                 430         
Tyr Pro Ile Ser Glu Leu Cys Lys Gln Phe Arg Leu Pro Phe Asn Val
        435                 440                 445             
Lys Val Ser Val Arg Asp Leu Ser Ile Glu Glu Asp Val Leu Ala Ala
    450                 455                 460                 
Thr Pro Gly Leu Gln Leu Glu Glu Asp Ile Thr Asp Ser Tyr Leu Leu
465                 470                 475                 480 
Ile Ser Asp Phe Ala Asn Pro Thr Glu Cys Trp Glu Ile Pro Val Gly
                485                 490                 495     
Arg Leu Asn Met Thr Val Gln Leu Val Ser Asn Phe Ser Arg Asp Ala
            500                 505                 510         
Glu Pro Phe Leu Val Arg Thr Leu Val Glu Glu Ile Thr Glu Glu Gln
        515                 520                 525             
Tyr Tyr Met Met Arg Arg Tyr Glu Ser Ser Ala Ser His Pro Pro Pro
    530                 535                 540                 
Arg Pro Pro Lys His Pro Ser Val Glu Glu Thr Lys Leu Thr Leu Leu
545                 550                 555                 560 
Thr Leu Ala Glu Glu Arg Thr Val Asp Leu Pro Lys Ser Pro Lys Asn
                565                 570                 575     
Thr Gly Thr Tyr Gly Pro Met Met Pro Ala Val Lys Ala Ile
            580                 585                 590 


<210> 2611
<211> 1328
<212> PRT
<213> Homo sapiens

<400> 2611
Met Glu Thr Gly Gln Arg Thr Ser Arg Lys Val Arg Lys Leu Gly Ser
 1               5                  10                  15      
Asn Arg Arg Arg Gln Thr Arg Glu Pro Ala Asp Gly Glu Gly Ala Ala
            20                  25                  30          
Val Ala Pro Glu Pro Glu Ser Trp Ser Ser Gln Ala Ala Ala Glu Leu
        35                  40                  45              
Gln Ala Phe Phe Gln Asp Cys Gly Ala Lys Glu Arg Gly Phe Val Thr
    50                  55                  60                  
Arg Glu Asp Leu Ala Val Ala Lys Phe Ser Phe Leu Gly Ser Lys Glu
65                  70                  75                  80  
Glu Ser Glu Met Ile Phe Asp Trp Val Asp Val Glu Arg Lys Gly His
                85                  90                  95      
Leu Ser Leu Glu Glu Phe Ser Ser Gly Leu Lys Asn Ile Phe Gly Ser
            100                 105                 110         
Ser Gln Ser Pro His Arg Leu Arg Arg Arg Lys Pro Leu Pro Ser Lys
        115                 120                 125             
Arg Val Ser Ala Thr Thr Ser Phe Pro Ala Leu Glu Glu Ala Asp Ala
    130                 135                 140                 
Glu Glu Lys Glu Ala Phe Leu Ala Phe Met Glu Gln Leu Gly Thr Gly
145                 150                 155                 160 
His Leu Leu Pro Lys Gln Met Glu Ile Trp Gln Leu Trp Gly Gln Leu
                165                 170                 175     
Arg Gln Glu Glu Pro Gln Leu Ala Gly Asn Leu Ala Gly Phe Leu Ala
            180                 185                 190         
Lys Met Thr Ser Arg Leu Gln Glu Ala Gln Ala Asp Lys Glu Ala Leu
        195                 200                 205             
Glu Leu Thr Leu Arg Lys Arg Asp Ser Asp His His Arg Glu Val Gln
    210                 215                 220                 
Gln Leu Tyr Glu Glu Met Glu Gln Gln Ile Arg Gln Glu Lys Gln Gln
225                 230                 235                 240 
Leu Gln Ala Glu Ser Asp Ser Arg Gly Leu Ala Leu Thr Ser Gln Met
                245                 250                 255     
Gln Asp Val Leu Glu Ala Lys Glu Arg Glu Val Gln Arg Leu Ala Glu
            260                 265                 270         
Gly Gln Arg Glu Leu Glu Ala Gln Leu Ser His Leu Arg Ser Thr His
        275                 280                 285             
Gln Glu Ala Ala Ser Glu Asn Gln Gln Leu Gln Glu Ala Lys Arg Asp
    290                 295                 300                 
Leu Ala Gly Arg Leu Glu Glu Val Arg Gly Gln Leu Gln Val Thr Arg
305                 310                 315                 320 
Gly Arg Leu Asp Ala Ala Arg Gly Arg Val Ser Trp Gln Val Glu Glu
                325                 330                 335     
Lys Leu Arg Gln Val Ala Ala Ile Pro Gly Leu Gly Phe Pro Gly Ala
            340                 345                 350         
Gly Glu Lys Thr Pro Asp Pro Gln Ala Ala Ser Pro Glu Glu Ala Pro
        355                 360                 365             
Leu Pro Gly Leu Phe Gly Asp Asn Asp Asp Trp Asp Gln Leu Leu Ser
    370                 375                 380                 
Asn Phe Gly Ser Pro Pro His Gly Ala Leu Gln Leu Cys Trp Ser Pro
385                 390                 395                 400 
Pro Pro Thr Pro Arg Ala Thr Ser Gly Pro Gln Thr Pro Arg Val Val
                405                 410                 415     
Arg Gln Ile Ser Ile Ser Glu Pro Gln Ala Phe Leu Phe Gly Gln Glu
            420                 425                 430         
Pro Ser Ser Asp Pro Asp Gly Ala Pro Arg Thr Pro Pro Gly Val Thr
        435                 440                 445             
Phe Ser Ala Lys Asp Asn Lys Gly Val Asp Pro His Glu Gln Asp Ile
    450                 455                 460                 
Arg Ala Glu Gln Pro Val Glu Pro His Asp Pro Asp Pro Asn Gln Glu
465                 470                 475                 480 
Pro Gly Ser Thr Pro Glu Gly Arg Leu Leu Trp Gly Leu Ser Gly Ser
                485                 490                 495     
Leu Val Ala Pro Ala Phe Lys Val Leu Ile Pro Leu Glu Asp Gly Pro
            500                 505                 510         
Pro Pro Pro Ala Asn Ser Pro Pro Pro Gln Ala Pro Ala Gly Ser Ser
        515                 520                 525             
Lys Gln Ile Gln Ala Ser Asp Pro Asp Asp Lys Gly Pro Gly Ser Trp
    530                 535                 540                 
Ala Pro Pro Ser Gly Ala Gln Pro Gly Ala Gly Ala Gly Pro Gln Glu
545                 550                 555                 560 
Pro Thr Gln Thr Pro Pro Thr Met Thr Glu Arg Glu Thr Gln Pro Gly
                565                 570                 575     
Pro Ser Pro Thr Thr Ala Leu Thr Gly Val Gly Pro Ala Lys Pro Pro
            580                 585                 590         
Arg Gln Arg Asp Ala Leu Gln Gln Asp Leu His Ala Thr Gly Ser Glu
        595                 600                 605             
Pro Arg Leu Gly Thr Gln Arg Ala Arg Ala Leu Thr Leu Gly Pro Ala
    610                 615                 620                 
Glu Pro Phe Gln Gly Leu Glu Phe Val Gly Pro Val Pro Thr Glu Arg
625                 630                 635                 640 
Leu Glu Gln Gly Gln Ala Gly Pro Ala Val Gln Glu Gly Leu Pro Glu
                645                 650                 655     
Gly Leu Arg Glu Ala His Gly Gln Val Leu Gly Leu Gly Glu Leu Ser
            660                 665                 670         
Ala Phe Pro His Gln Glu Leu Glu Glu Glu Pro Arg Ser Glu Glu Gly
        675                 680                 685             
Lys Gln Glu Gly Arg Gly Gly Gln Asp Leu Ser Ser Glu Gln Ser Glu
    690                 695                 700                 
Gln Ser Val Glu Ala His Gly Leu Glu Thr Ala His Ser Glu Leu Pro
705                 710                 715                 720 
Gln Gln Asp Ser Leu Leu Val Ser Leu Pro Ser Ala Thr Pro Gln Ala
                725                 730                 735     
Gln Val Glu Ala Glu Gly Pro Thr Pro Gly Lys Ser Ala Pro Pro Arg
            740                 745                 750         
Gly Ser Pro Pro Arg Gly Ala Gln Pro Gly Ala Gly Ala Gly Pro Gln
        755                 760                 765             
Glu Pro Thr Gln Thr Pro Pro Thr Met Ala Glu Gln Glu Ala Gln Pro
    770                 775                 780                 
Arg Pro Ser Leu Thr Thr Ala His Ala Glu Glu Gln Gly Pro Pro His
785                 790                 795                 800 
Ser Arg Glu Pro Arg Ala Glu Ser Arg Leu Glu Asp Pro Gly Met Asp
                805                 810                 815     
Ser Arg Glu Ala Gly Leu Thr Pro Ser Pro Gly Asp Pro Met Ala Gly
            820                 825                 830         
Gly Gly Pro Gln Ala Asn Pro Asp Tyr Leu Phe His Val Ile Phe Leu
        835                 840                 845             
Gly Asp Ser Asn Val Gly Lys Thr Ser Phe Leu His Leu Leu His Gln
    850                 855                 860                 
Asn Ser Phe Ala Thr Gly Leu Thr Ala Thr Val Gly Val Asp Phe Arg
865                 870                 875                 880 
Val Lys Thr Leu Leu Val Asp Asn Lys Cys Phe Val Leu Gln Leu Trp
                885                 890                 895     
Asp Thr Ala Gly Gln Glu Arg Tyr His Ser Met Thr Arg Gln Leu Leu
            900                 905                 910         
Arg Lys Ala Asp Gly Val Val Leu Met Tyr Asp Ile Thr Ser Gln Glu
        915                 920                 925             
Ser Phe Ala His Val Arg Tyr Trp Leu Asp Cys Leu Gln Asp Ala Gly
    930                 935                 940                 
Ser Asp Gly Val Val Ile Leu Leu Leu Gly Asn Lys Met Asp Cys Glu
945                 950                 955                 960 
Glu Glu Arg Gln Val Ser Val Glu Ala Gly Gln Gln Leu Ala Gln Glu
                965                 970                 975     
Leu Gly Val Tyr Phe Gly Glu Cys Ser Ala Ala Leu Gly His Asn Ile
            980                 985                 990         
Leu Glu Pro Val Val Asn Leu Ala Ser Ser Glu Arg Asn Val Ser Ala
        995                 1000                1005            
Ala Val Ser Leu Pro Ser Pro Glu Ala His Lys Lys Thr Gly Asn Ser
    1010                1015                1020                
Gly Ser Gln Glu Val Glu Phe Trp Glu Glu Leu His Thr Ala Gln His
1025                1030                1035                1040
Pro Leu Leu Ala Phe Leu Gly Arg Ile His Leu Leu Gly Arg Ala Gln
                1045                1050                1055    
Leu Cys Lys Asp His Gln Pro Phe Leu Leu Ser Lys Gly Ser Gln Ala
            1060                1065                1070        
Arg Glu Gln Asp Pro Gly Thr Ser Glu Gln His Lys Val Gly Asn Asp
        1075                1080                1085            
Ser Ser Arg Arg Asn Leu Arg Met Glu Pro Asn Ala Thr Phe Thr Thr
    1090                1095                1100                
Gln Leu Thr Ala Thr Pro Glu Arg Leu Leu Arg Leu Ile Ser Ala Gly
1105                1110                1115                1120
Val Cys Gly Leu Ile Leu Leu Val Gly Leu Ser Ala Asn Gly Leu Met
                1125                1130                1135    
Leu Leu Val Val Gly Arg Gly Pro Gly Ser Pro His Pro Leu His Ser
            1140                1145                1150        
Leu Thr His Ser Leu Met Met Asn Ile Thr Pro Ser Asp Leu Leu Phe
        1155                1160                1165            
Leu Ala Cys Val Val Pro Val Leu Leu Leu Ser Phe Leu Gln His Asn
    1170                1175                1180                
Trp Trp Leu Gly Pro Ala Ile Cys Thr Ile Ser Gln Ala Thr Asn Thr
1185                1190                1195                1200
Ala Thr Thr Phe Cys Ile Phe Tyr Ser Met Val Ala Thr Ala Leu Leu
                1205                1210                1215    
Arg His Val Ala Val Ala Arg Pro Asp Leu Ala Phe Pro Ala Gly Trp
            1220                1225                1230        
Gly Thr Leu Leu Leu Leu Cys Gly Ala Met Trp Ala Leu Gly Leu Thr
        1235                1240                1245            
Glu Ser Leu Pro Asn Trp Leu Phe Gln Arg Val Ala Val Glu Glu Glu
    1250                1255                1260                
Thr Ala Gly Ala Pro Lys Thr Gln Ala Cys Leu Leu Leu Leu Ser Pro
1265                1270                1275                1280
Ala Gly Thr Ser Cys Tyr Ile Ser Leu Leu Gly Ala Leu Ala Phe Leu
                1285                1290                1295    
Pro Cys Thr Leu Gly Leu Gly Cys Ser Phe Ser His Val Gly Trp Leu
            1300                1305                1310        
Leu Trp Thr Gln Pro Gln Gly Pro Met Gly Glu Ser Ile Gln Glu His
        1315                1320                1325            


<210> 2612
<211> 230
<212> PRT
<213> Homo sapiens

<400> 2612
Met Gly Lys Arg Glu Glu Asn Gly Cys Phe Pro Gln Met Ser Asn Cys
 1               5                  10                  15      
Thr Tyr Gln Glu Gly Val Met Glu Gly Leu Trp Ala Leu Tyr Asp Ser
            20                  25                  30          
Trp Val Ser Leu Ile Glu Asp Phe Met Gly Ser Ser Gln Lys Lys Arg
        35                  40                  45              
Lys Lys Lys His Ile Phe Cys Gly Gly Asp Phe His Gln Lys Ser Pro
    50                  55                  60                  
Pro Tyr Gln Ser Val Gly Gly Gln Tyr Gln Lys Asp Pro Leu Ile Pro
65                  70                  75                  80  
Gly Ser Leu Arg Arg Tyr Leu Thr Val Glu Gly Thr Lys Ala Ser Ser
                85                  90                  95      
Ala Ser Ser Glu Thr Pro Pro Phe Leu Ser Ser Phe Phe Ser Ser Lys
            100                 105                 110         
Arg Glu Ile Ile Val Gln His Tyr Arg Gly Tyr Asn Ser Val Pro Arg
        115                 120                 125             
Asn Pro Cys Met Asn Glu Lys Ser Arg Asn Thr Lys Asp Ala His Pro
    130                 135                 140                 
Ala Ser His Leu Thr Gln Ser Ser Ser Asp Gly Ala Asp Glu Met Val
145                 150                 155                 160 
Gln Met Asp Pro Ser Ala Leu Glu Arg Pro Glu Gly Glu Val Ser Ser
                165                 170                 175     
Ala Arg Arg Val Gly Gly Glu His Asn Arg Ala Leu Ser Ser Lys Gly
            180                 185                 190         
Leu Ile Val Gly Pro Gly Tyr Thr Pro Arg Arg Leu Ala Glu Glu Leu
        195                 200                 205             
Arg Val Arg Glu Lys Ala Val Gly Gln Ser Glu Val Pro Met Leu Lys
    210                 215                 220                 
Gly Leu Ser Leu Met Ile
225                 230 


<210> 2613
<211> 400
<212> PRT
<213> Homo sapiens

<400> 2613
Met Gly Lys Glu His Thr His Ile Ser Ile Val Val Ile Gly His Tyr
 1               5                  10                  15      
Ala Trp Val Leu Asp Lys Leu Lys Ala Glu Cys Glu His Gly Met Thr
            20                  25                  30          
Ile Asp Ile Ser Leu Pro Lys Phe Glu Thr Ser Lys Tyr Tyr Met Thr
        35                  40                  45              
Ile Ile Asp Ser Pro Gly His Arg His Phe Ile Lys Asn Met Ile Ile
    50                  55                  60                  
Gly Thr Ser Gln Ala Asp Arg Ala Val Leu Ile Val Ala Ala Gly Ala
65                  70                  75                  80  
Gly Glu Ser Glu Ala Gly Ile Ser Lys Asn Gly His Thr His Glu His
                85                  90                  95      
Ala Leu Leu Ala Tyr Thr Leu Gly Gly Lys Gln Leu Ile Val Asp Val
            100                 105                 110         
Asn Lys Met Asp Pro Thr Glu Thr Pro Tyr Ser Gln Lys Lys Tyr Lys
        115                 120                 125             
Ser Leu Lys Lys Ser Ala Leu Ser Leu Arg Lys Leu Thr Thr Ala Pro
    130                 135                 140                 
Gly Thr Val Val Ala Phe Val Pro Val Ser Gly Trp Asn Gly Asp Thr
145                 150                 155                 160 
Met Leu Glu Pro Ser Ala Asn Met Pro Trp Phe Lys Gly Trp Lys Val
                165                 170                 175     
Thr His Lys Asp Val Asn Ala Ser Gly Thr Lys Leu Leu Glu Ala Leu
            180                 185                 190         
Asp Cys Ile Leu Thr Pro Ala Cys Pro Thr Asp Arg Pro Ser Pro Leu
        195                 200                 205             
Pro Leu Gln Asp Val Tyr Lys Ile Gly Gly Val Ala Thr Leu Pro Ile
    210                 215                 220                 
Gly Gly Val Glu Thr Gly Val Leu Lys Pro Gly Arg Asn Asn Val Ala
225                 230                 235                 240 
Phe Asn Val Lys Asn Val Ser Val Lys Asn Val His Cys Gly Asn Val
                245                 250                 255     
Ala Gly Asp Asn Lys Asn Asp Pro Pro Thr Glu Thr Thr Gly Phe Ala
            260                 265                 270         
Ala Gln Val Ile Ile Leu Lys His Pro Val Gln Ile Ser Ala Gly Tyr
        275                 280                 285             
Ser Pro Leu Leu Asp Cys His Thr Asp His Ile Ala Cys Lys Phe Ala
    290                 295                 300                 
Glu Leu Lys Glu Lys Ile Asp Cys His Ser Gly Lys Lys Leu Lys Asp
305                 310                 315                 320 
Gly Pro Lys Phe Leu Lys Ser Gly Asp Val Ala Thr Lys Phe Leu Asn
                325                 330                 335     
Ser Gly Asp Val Asp Met Val Leu Gly Lys Pro Met Cys Val Glu Val
            340                 345                 350         
Phe Ser Asp Tyr Pro Pro Leu Gly Cys Phe Ala Val His Asp Met Arg
        355                 360                 365             
Trp Arg Ile Ala Met Asp Val Ile Lys Ala Val Asp Lys Lys Ala Ala
    370                 375                 380                 
Gly Ala Gly Lys Ile Thr Thr Ser Ala Gln Lys Val Gln Lys Ala Lys
385                 390                 395                 400 


<210> 2614
<211> 253
<212> PRT
<213> Homo sapiens

<400> 2614
Met Ala Thr His Arg Leu Val Met Val Arg His Gly Glu Ser Thr Trp
 1               5                  10                  15      
Asn Gln Glu Asn Arg Phe Cys Gly Trp Phe Asp Ala Glu Leu Ser Glu
            20                  25                  30          
Lys Gly Thr Glu Glu Ala Lys Arg Gly Ala Lys Ala Ile Lys Asp Ala
        35                  40                  45              
Lys Met Glu Phe Asp Ile Cys Tyr Thr Ser Val Leu Lys Arg Ala Ile
    50                  55                  60                  
Arg Thr Leu Trp Ala Ile Leu Asp Gly Thr Asp Gln Met Trp Leu Pro
65                  70                  75                  80  
Val Val Arg Thr Trp Arg Leu Asn Glu Arg His Tyr Gly Gly Leu Thr
                85                  90                  95      
Gly Leu Asn Lys Ala Glu Thr Ala Ala Lys His Gly Glu Glu Gln Val
            100                 105                 110         
Lys Ile Trp Arg Arg Ser Phe Asp Ile Pro Pro Pro Pro Met Asp Glu
        115                 120                 125             
Lys His Pro Tyr Tyr Asn Ser Ile Ser Lys Glu Arg Arg Tyr Ala Gly
    130                 135                 140                 
Leu Lys Pro Gly Glu Leu Pro Thr Cys Glu Ser Leu Lys Asp Thr Ile
145                 150                 155                 160 
Ala Arg Ala Leu Pro Phe Trp Asn Glu Glu Ile Val Pro Gln Ile Lys
                165                 170                 175     
Ala Gly Lys Arg Val Leu Ile Ala Ala His Gly Asn Ser Leu Arg Gly
            180                 185                 190         
Ile Val Lys His Leu Glu Gly Met Ser Asp Gln Ala Ile Met Glu Leu
        195                 200                 205             
Asn Leu Pro Thr Gly Ile Pro Ile Val Tyr Glu Leu Asn Lys Glu Leu
    210                 215                 220                 
Lys Pro Thr Lys Pro Met Gln Phe Leu Gly Asp Glu Glu Thr Val Arg
225                 230                 235                 240 
Lys Ala Met Glu Ala Val Ala Ala Gln Gly Lys Ala Lys
                245                 250             


<210> 2615
<211> 133
<212> PRT
<213> Homo sapiens

<400> 2615
Met Gly Ile Asp Gly Ala Pro Leu His Arg Gly Lys Val Arg Ser Pro
 1               5                  10                  15      
Glu Tyr Gln Ala Ala Gly Ala Leu Gly Asp Thr Arg Thr Glu Pro Ser
            20                  25                  30          
Leu Asp Gln Val Leu Gln Glu Arg Asp Glu Ala Ile Ala Lys Lys Gln
        35                  40                  45              
Ala Val Glu Ala Glu Leu Gln Arg Cys Lys Ala Arg Leu His Ala Met
    50                  55                  60                  
Glu Ala Gln Leu Leu Glu Val Leu Glu Glu Lys Leu Arg Leu Arg Arg
65                  70                  75                  80  
Glu Leu Glu Ala Trp Glu Glu Asp Val Gln Gln Leu Val Trp Gln Gln
                85                  90                  95      
Val Gln Asn Gln Leu Gln Arg Glu Ala Lys Gly Thr Arg Gly Ala His
            100                 105                 110         
Val Asp Pro Gly Ala Ala Ser Thr Pro Arg Ser Arg Phe Ser Leu Gly
        115                 120                 125             
Arg Gly Arg Trp Trp
    130             


<210> 2616
<211> 766
<212> PRT
<213> Homo sapiens

<400> 2616
Met Ala Ala Leu Ser Gly Gly Gly Gly Gly Gly Ala Glu Pro Gly Gln
 1               5                  10                  15      
Ala Leu Phe Asn Gly Asp Met Glu Pro Glu Ala Gly Ala Gly Ala Gly
            20                  25                  30          
Ala Ala Ala Ser Ser Ala Ala Asp Pro Ala Ile Pro Glu Glu Val Trp
        35                  40                  45              
Asn Ile Lys Gln Met Ile Lys Leu Thr Gln Glu His Ile Glu Ala Leu
    50                  55                  60                  
Leu Asp Lys Phe Gly Gly Glu His Asn Pro Pro Ser Ile Tyr Leu Glu
65                  70                  75                  80  
Ala Tyr Glu Glu Tyr Thr Ser Lys Leu Asp Ala Leu Gln Gln Arg Glu
                85                  90                  95      
Gln Gln Leu Leu Glu Ser Leu Gly Asn Gly Thr Asp Phe Ser Val Ser
            100                 105                 110         
Ser Ser Ala Ser Met Asp Thr Val Thr Ser Ser Ser Ser Ser Ser Leu
        115                 120                 125             
Ser Val Leu Pro Ser Ser Leu Ser Val Phe Gln Asn Pro Thr Asp Val
    130                 135                 140                 
Ala Arg Ser Asn Pro Lys Ser Pro Gln Lys Pro Ile Val Arg Val Phe
145                 150                 155                 160 
Leu Pro Asn Lys Gln Arg Thr Val Val Pro Ala Arg Cys Gly Val Thr
                165                 170                 175     
Val Arg Asp Ser Leu Lys Lys Ala Leu Met Met Arg Gly Leu Ile Pro
            180                 185                 190         
Glu Cys Cys Ala Val Tyr Arg Ile Gln Asp Gly Glu Lys Lys Pro Ile
        195                 200                 205             
Gly Trp Asp Thr Asp Ile Ser Trp Leu Thr Gly Glu Glu Leu His Val
    210                 215                 220                 
Glu Val Leu Glu Asn Val Pro Leu Thr Thr His Asn Phe Val Arg Lys
225                 230                 235                 240 
Thr Phe Phe Thr Leu Ala Phe Cys Asp Phe Cys Arg Lys Leu Leu Phe
                245                 250                 255     
Gln Gly Phe Arg Cys Gln Thr Cys Gly Tyr Lys Phe His Gln Arg Cys
            260                 265                 270         
Ser Thr Glu Val Pro Leu Met Cys Val Asn Tyr Asp Gln Leu Asp Leu
        275                 280                 285             
Leu Phe Val Ser Lys Phe Phe Glu His His Pro Ile Pro Gln Glu Glu
    290                 295                 300                 
Ala Ser Leu Ala Glu Thr Ala Leu Thr Ser Gly Ser Ser Pro Ser Ala
305                 310                 315                 320 
Pro Ala Ser Asp Ser Ile Gly Pro Gln Ile Leu Thr Ser Pro Ser Pro
                325                 330                 335     
Ser Lys Ser Ile Pro Ile Pro Gln Pro Phe Arg Pro Ala Asp Glu Asp
            340                 345                 350         
His Arg Asn Gln Phe Gly Gln Arg Asp Arg Ser Ser Ser Ala Pro Asn
        355                 360                 365             
Val His Ile Asn Thr Ile Glu Pro Val Asn Ile Asp Asp Leu Ile Arg
    370                 375                 380                 
Asp Gln Gly Phe Arg Gly Asp Gly Gly Ser Thr Thr Gly Leu Ser Ala
385                 390                 395                 400 
Thr Pro Pro Ala Ser Leu Pro Gly Ser Leu Thr Asn Val Lys Ala Leu
                405                 410                 415     
Gln Lys Ser Pro Gly Pro Gln Arg Glu Arg Lys Ser Ser Ser Ser Ser
            420                 425                 430         
Glu Asp Arg Asn Arg Met Lys Thr Leu Gly Arg Arg Asp Ser Ser Asp
        435                 440                 445             
Asp Trp Glu Ile Pro Asp Gly Gln Ile Thr Val Gly Gln Arg Ile Gly
    450                 455                 460                 
Ser Gly Ser Phe Gly Thr Val Tyr Lys Gly Lys Trp His Gly Asp Val
465                 470                 475                 480 
Ala Val Lys Met Leu Asn Val Thr Ala Pro Thr Pro Gln Gln Leu Gln
                485                 490                 495     
Ala Phe Lys Asn Glu Val Gly Val Leu Arg Lys Thr Arg His Val Asn
            500                 505                 510         
Ile Leu Leu Phe Met Gly Tyr Ser Thr Lys Pro Gln Leu Ala Ile Val
        515                 520                 525             
Thr Gln Trp Cys Glu Gly Ser Ser Leu Tyr His His Leu His Ile Ile
    530                 535                 540                 
Glu Thr Lys Phe Glu Met Ile Lys Leu Ile Asp Ile Ala Arg Gln Thr
545                 550                 555                 560 
Ala Gln Gly Met Asp Tyr Leu His Ala Lys Ser Ile Ile His Arg Asp
                565                 570                 575     
Leu Lys Ser Asn Asn Ile Phe Leu His Glu Asp Leu Thr Val Lys Ile
            580                 585                 590         
Gly Asp Phe Gly Leu Ala Thr Val Lys Ser Arg Trp Ser Gly Ser His
        595                 600                 605             
Gln Phe Glu Gln Leu Ser Gly Ser Ile Leu Trp Met Ala Pro Glu Val
    610                 615                 620                 
Ile Arg Met Gln Asp Lys Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr
625                 630                 635                 640 
Ala Phe Gly Ile Val Leu Tyr Glu Leu Met Thr Gly Gln Leu Pro Tyr
                645                 650                 655     
Ser Asn Ile Asn Asn Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly
            660                 665                 670         
Tyr Leu Ser Pro Asp Leu Ser Lys Val Arg Ser Asn Cys Pro Lys Ala
        675                 680                 685             
Met Lys Arg Leu Met Ala Glu Cys Leu Lys Lys Lys Arg Asp Glu Arg
    690                 695                 700                 
Pro Leu Phe Pro Gln Ile Leu Ala Ser Ile Glu Leu Leu Ala Arg Ser
705                 710                 715                 720 
Leu Pro Lys Ile His Arg Ser Ala Ser Glu Pro Ser Leu Asn Arg Ala
                725                 730                 735     
Gly Phe Gln Thr Glu Asp Phe Ser Leu Tyr Ala Cys Ala Ser Pro Lys
            740                 745                 750         
Thr Pro Ile Gln Ala Gly Gly Tyr Gly Ala Phe Pro Val His
        755                 760                 765     


<210> 2617
<211> 485
<212> PRT
<213> Homo sapiens

<400> 2617
Met Gly Ala Thr Val Ser Leu Ser Glu His Lys Ala Phe Ile His Ser
 1               5                  10                  15      
Arg Ala Gly Arg Ala Gly Pro Gly Ala Pro Leu Arg Ala Ala Leu Ala
            20                  25                  30          
Arg Thr Pro Val Glu Leu Ala Ala Glu Cys Ala Ala Pro Ala Leu Arg
        35                  40                  45              
Ala Ala Ala Ala Gly Ala Lys Ile Leu Gly Gly Gly Ala Ala Ala Ala
    50                  55                  60                  
Lys Ser Gly Gly Gly Gly Ala Lys Ser Arg Gly Gly Lys Lys Lys Gln
65                  70                  75                  80  
Thr His Lys Lys Pro Arg Arg Arg Gly Glu Lys Ala Thr Ala Gly Lys
                85                  90                  95      
Lys Pro Arg Arg Arg Gly Gln Lys Thr Ala Glu Ala Gly Ala Lys Ser
            100                 105                 110         
His Gly Val Gly Gly Lys Ser Tyr Gly Gly Gly Ala Lys Ser Arg Gly
        115                 120                 125             
Gly Glu Val Lys Lys Pro Gln Lys Ala Ala Ala Ala Gly Gly Lys Ser
    130                 135                 140                 
Arg Lys Lys Gln Arg Arg Arg Gly Gln Lys Ala Ala Ala Ala Lys Ser
145                 150                 155                 160 
Leu Ser Gly Gly Gly Lys Lys Pro Arg Pro Gly Glu Lys Ala Ala Ala
                165                 170                 175     
Ala Gly Ala Lys Ser His Gly Gly Arg Glu Gln Lys Pro Ala Gly Val
            180                 185                 190         
Gly Ala Lys Ser Arg Gly Gly Gly Leu Lys Ser Arg Val Ser Lys Thr
        195                 200                 205             
Arg Gly Gly Gly Arg Lys Lys Pro Arg Arg Gly Gln Lys Ala Ala Lys
    210                 215                 220                 
Asn Arg Gly Cys Gly Gly Lys Ser Arg Gly Ser Arg Gly Arg Lys Gln
225                 230                 235                 240 
Gln Lys Pro Lys Ala Ala Lys Ser Leu Gly Gly Gly Gly Trp Gly Gly
                245                 250                 255     
Ala Lys Asn Arg Gly Glu Gly Gly Lys Lys Pro Arg Cys Arg Gly Lys
            260                 265                 270         
Lys Pro Trp Pro Arg Arg Gln Lys Pro Ala Ala Ala Lys Ser Pro Gly
        275                 280                 285             
Gly Ala Asp Lys Lys Pro Arg Arg Trp Gly Ser Lys Ala Ala Ser Ala
    290                 295                 300                 
Lys Pro Met Val Glu Gly Gly Lys Lys Pro Trp Arg Arg Ala Gln Lys
305                 310                 315                 320 
Met Gln Lys Ala Ala Glu Gly Ala Lys Ser Cys Lys Lys Gln Arg Arg
                325                 330                 335     
Arg Arg Gln Asn Ala Thr Thr Glu Lys Ser Leu Gly Gly Gly Gly Lys
            340                 345                 350         
Asn Pro Arg Lys Arg Gly Glu Lys Ala Ala Glu Ala Gly Gly Lys Ser
        355                 360                 365             
Arg Gly Gly Gly Gly Lys Arg Gln Arg Asp Arg Gly Lys Lys Pro Gln
    370                 375                 380                 
Lys Ser Ala Ala Ala Gly Ala Lys Ser Cys Lys Lys Gln Arg Trp Arg
385                 390                 395                 400 
Gly Gln Lys Ala Ser Lys Arg Ser Gly Gly Gly Asp Lys Lys Leu Gln
                405                 410                 415     
Lys Ala Ala Ala Ala Gly Ala Lys Ser Pro Ser Gly Lys Lys Gln Arg
            420                 425                 430         
Leu Trp Gly Gln Lys Ala Met Val Ala Lys Ser Leu Gly Gly Gly Gly
        435                 440                 445             
Lys Lys Pro Arg Arg Arg Glu Gln Lys Gly Ala Gly Ala Lys Asn Gln
    450                 455                 460                 
Lys Asn Leu Arg Gln Arg Arg Glu Lys Ser Arg Gly Gly Gly Gly Lys
465                 470                 475                 480 
Ile Val Glu Met Gly
                485 


<210> 2618
<211> 383
<212> PRT
<213> Homo sapiens

<400> 2618
Met Leu Val Ala Arg Gly Leu Ser Arg Leu Leu Pro Val Glu Ser Ala
 1               5                  10                  15      
Pro Phe Leu Ile Leu His Pro Thr Pro Ala Ser Arg Ala Arg Ala Glu
            20                  25                  30          
Ala Gln Ala Ala Met Leu Val Ala Arg Gly Leu Ser Arg Leu Leu Pro
        35                  40                  45              
Val Glu Ser Gln Leu Gln Ser Ser Ser Glu Trp Leu His Gln Asp Val
    50                  55                  60                  
Trp Asp Leu Tyr Gln Asp Met Gly Lys Lys Lys Ala Leu Ala Cys Ser
65                  70                  75                  80  
Pro Asp Cys Tyr Ser Lys Ala Pro Gln Met Glu Ala Pro Leu Ser Ile
                85                  90                  95      
Asp Pro Glu Ala Leu Arg Val Ala Ala Arg Gly Glu Met Leu Asn Ile
            100                 105                 110         
Ser Arg His Phe His Leu Arg Ser Leu Trp Gln Glu Gln Thr Pro Leu
        115                 120                 125             
Lys Gln Ala Ala Leu Ser Gln Ala Gly Ala Gly Leu Ala Gly Cys Arg
    130                 135                 140                 
Val Pro Arg Lys His Val Gln Ala Phe Leu Trp Gly Asn Gln Glu Lys
145                 150                 155                 160 
Trp Thr Asp Trp Glu Lys Ala Ser Gly Asp Gln Val Lys Pro Ile Thr
                165                 170                 175     
Ile Ile Ile Glu Thr Val Ala Gly Lys Ile Leu Gly Pro Ser Thr Gly
            180                 185                 190         
Ser Gly Arg Arg Thr Asp Pro Thr Ser Thr Leu Thr Gln Asp Asp Ala
        195                 200                 205             
Gln Thr Pro His Pro Pro Ser Pro Arg Thr Thr His Arg Pro His Ile
    210                 215                 220                 
His Pro His Pro Gly Arg Arg Thr Asp Pro Thr Ser Thr Leu Thr Gln
225                 230                 235                 240 
Asp Asp Ala Gln Thr Pro Pro Arg Ser Ala Glu Pro Pro Ser Ser Leu
                245                 250                 255     
His Leu Pro Leu Ala Met Leu Pro Thr Ala Gly Ser Ala Glu Pro Pro
            260                 265                 270         
Ser Ser Leu His Leu Pro Leu Ala Met Leu Pro Pro Ala Gly Tyr Ala
        275                 280                 285             
Glu Pro Pro Ser Ser Leu His Leu Pro Leu Ala Met Leu Pro Thr Ala
    290                 295                 300                 
Gly Tyr Ala Glu Pro Pro Ser Ser Leu Arg Ile Gln Thr Gln Ser Glu
305                 310                 315                 320 
Lys Thr Pro Asp Ser Lys Ala Phe Pro Ile Thr Gln Asp Lys Glu Ser
                325                 330                 335     
Arg Lys Trp Glu Thr Val Leu Ala Ser Ala Ser Arg Glu Pro Gln Ser
            340                 345                 350         
Pro His Lys Val Ser Ile Ala Leu Asp Gly Pro Trp Glu Phe Leu Arg
        355                 360                 365             
Ala Pro Glu Ala Ser Gly Ala Gly Gly Arg Pro His Arg His Phe
    370                 375                 380             


<210> 2619
<211> 251
<212> PRT
<213> Homo sapiens

<400> 2619
Met Thr His Ile Val Trp Glu Val Asp Arg Pro Gly Ser Lys Val Asn
 1               5                  10                  15      
Lys Lys Glu Val Val Glu Ala Val Thr Ile Val Glu Ile Thr Met Val
            20                  25                  30          
Val Ala Gly Ile Val Gly Tyr Val Gly Thr Pro Arg Gly Leu Trp Thr
        35                  40                  45              
Phe Lys Thr Val Phe Thr Glu His Ile Ser Asp Glu Cys Lys Arg His
    50                  55                  60                  
Phe Tyr Lys Asn Trp His Lys Ser Lys Lys Lys Ala Phe Thr Lys Tyr
65                  70                  75                  80  
Cys Lys Lys Trp Leu Asp Glu Asp Gly Lys Lys Gln Leu Glu Lys Asp
                85                  90                  95      
Phe Ser Ser Met Lys Lys Tyr Cys Gln Lys Ala His Val Met Glu Ile
            100                 105                 110         
Gln Val Asn Arg Gly Thr Val Ala Glu Lys Leu Asp Trp Ala Arg Glu
        115                 120                 125             
Arg Leu Glu Gln Gln Val Pro Val Asn Gln Val Phe Gly Gln Asp Glu
    130                 135                 140                 
Met Ile Asp Val Ile Gly Ala Trp His Pro Asp Arg Val Ala Phe Ser
145                 150                 155                 160 
Gly Ala Arg Thr Gly Gln Lys Glu Tyr His His Cys Thr Lys Ile Asn
                165                 170                 175     
Lys Lys Ile Tyr Lys Ile Gly Gln Ser Tyr Leu Ile Lys Gly Gly Lys
            180                 185                 190         
Leu Ile Lys Asn Asn Ala Ser Thr Asp Tyr Asp Leu Ser Val Lys Ser
        195                 200                 205             
Ile Asn Pro Leu Gly Gly Phe Val His Tyr Gly Glu Val Thr Asn Asp
    210                 215                 220                 
Phe Val Met Leu Lys Gly Cys Val Val Val Thr Lys Lys Arg Val Leu
225                 230                 235                 240 
Thr Leu His Lys Ser Leu Leu Val Gln Thr Lys
                245                 250     


<210> 2620
<211> 199
<212> PRT
<213> Homo sapiens

<400> 2620
Met Val Phe Tyr Phe Thr Ser Ser Ser Val Asn Ser Ser Ala Tyr Thr
 1               5                  10                  15      
Ile Tyr Met Gly Lys Asp Lys Tyr Glu Asn Glu Asp Leu Ile Lys His
            20                  25                  30          
Gly Trp Pro Glu Asp Ile Trp Phe His Val Asp Lys Leu Ser Ser Ala
        35                  40                  45              
His Val Tyr Leu Arg Leu His Lys Gly Glu Asn Ile Glu Asp Ile Pro
    50                  55                  60                  
Lys Glu Val Leu Met Asp Cys Ala His Leu Val Lys Ala Asn Ser Ile
65                  70                  75                  80  
Gln Gly Cys Lys Met Asn Asn Val Asn Val Val Tyr Thr Pro Trp Ser
                85                  90                  95      
Asn Leu Lys Lys Thr Ala Asp Met Asp Val Gly Gln Ile Gly Phe His
            100                 105                 110         
Arg Gln Lys Asp Val Lys Ile Val Thr Val Glu Lys Lys Val Asn Glu
        115                 120                 125             
Ile Leu Asn Arg Leu Glu Lys Thr Lys Val Glu Arg Phe Pro Asp Leu
    130                 135                 140                 
Ala Ala Glu Lys Glu Cys Arg Asp Arg Glu Glu Arg Asn Glu Lys Lys
145                 150                 155                 160 
Ala Gln Ile Gln Glu Met Lys Lys Arg Glu Lys Glu Glu Met Lys Lys
                165                 170                 175     
Lys Arg Glu Met Asp Glu Leu Arg Tyr Val Gly Ala Val Ala Leu Arg
            180                 185                 190         
Leu Thr Ser Lys Ile Ile Pro
        195                 


<210> 2621
<211> 249
<212> PRT
<213> Homo sapiens

<400> 2621
Met Ala Ala Lys Met Phe Glu Phe Ile Gly Lys Phe Gly Leu Ala Leu
 1               5                  10                  15      
Val Val Ala Gly Gly Val Val Asn Ser Ala Leu Tyr Ser Val Asp Ala
            20                  25                  30          
Gly His Arg Ala Val Val Phe Asp Arg Phe Arg Gly Val Gln Asp Ile
        35                  40                  45              
Val Pro Arg Asn Val Pro Val Ile Thr Gly Ser Lys Asp Leu Gln Asn
    50                  55                  60                  
Val Asn Leu Thr Leu Arg Ile Ile Phe Arg Pro Val Ala Ser Gln Leu
65                  70                  75                  80  
Pro His Ile Phe Thr Ser Ser Gly Glu Asp His Asp Glu Arg Val Pro
                85                  90                  95      
Pro Ser Ile Thr Asn Lys Ile Leu Lys Ser Val Val Ala Arg Phe Glu
            100                 105                 110         
Ala Gly Glu Leu Ile Thr Gln Arg Glu Gln Ile Ser Arg Gln Val Ser
        115                 120                 125             
Asp Asp Leu Thr Glu Pro Ala Ala Thr Phe Gly Leu Ile Leu Asp Asp
    130                 135                 140                 
Val Ser Leu Thr Tyr Leu Thr Phe Gly Lys Glu Phe Ile Glu Ala Val
145                 150                 155                 160 
Glu Ala Lys Gln Ile Ala Gln Gln Glu Ala Glu Arg Ala Arg Phe Val
                165                 170                 175     
Val Glu Lys Ala Glu Gln Gln Lys Lys Ala Ala Ile Ile Ser Ala Glu
            180                 185                 190         
Gly Asp Ser Lys Val Ala Glu Leu Ile Thr Asn Ser Leu Ala Thr Ala
        195                 200                 205             
Gly Asp Ala Leu Ile Glu Leu Arg Lys Leu Glu Ala Val Glu Asp Ile
    210                 215                 220                 
Thr Tyr Gln Leu Leu Arg Ser Arg Asn Ile Thr Tyr Leu Arg Ala Gly
225                 230                 235                 240 
Gln Ser Met Pro Leu Gln Leu Arg Trp
                245                 


<210> 2622
<211> 158
<212> PRT
<213> Homo sapiens

<400> 2622
Met Glu Thr Val Val Thr Thr Leu Pro Arg Glu Gly Gly Val Gly Pro
 1               5                  10                  15      
Ser Arg Lys Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ser
            20                  25                  30          
Gly Leu Ser Ala Val Val Ser Gln His Pro Ser Arg Val Ile Cys Lys
        35                  40                  45              
Ser Gly Thr Ser Val Asn Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala
    50                  55                  60                  
Thr Thr Met Phe Trp Tyr Arg Gln Leu Arg Lys Gln Ser Leu Met Leu
65                  70                  75                  80  
Met Ala Thr Ser Asn Glu Gly Ser Glu Val Thr Tyr Glu Gln Gly Val
                85                  90                  95      
Lys Lys Asp Lys Phe Pro Ile Asn His Pro Asn Leu Thr Phe Ser Ala
            100                 105                 110         
Leu Thr Val Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys
        115                 120                 125             
Ser Ala Arg Asp Thr Ala Pro Gly Gly Asp Gln Arg Pro Arg Gln Glu
    130                 135                 140                 
Pro Leu Gln Leu Leu Leu His Pro Ser Arg Pro Thr Glu Cys
145                 150                 155             


<210> 2623
<211> 127
<212> PRT
<213> Homo sapiens

<400> 2623
Met Ala Asp Leu Gly Leu Gly Gly Gly Gly Lys Ala Thr Arg Ser Arg
 1               5                  10                  15      
Gly Gly Ser Gly Ala Gly Gly Gly Arg Leu Lys Ser Arg His His Glu
            20                  25                  30          
Glu Ala Leu Gln Leu Arg Glu Thr Pro Gly Pro Gly Ala Pro Gly Leu
        35                  40                  45              
His Gly Pro Arg Val Arg Trp Ser Gly Val Pro His Pro Gly Leu Gly
    50                  55                  60                  
Thr Ala Glu Asp Pro Gln Gly Cys His Gln Gly Arg Arg Arg Gly Gly
65                  70                  75                  80  
Gly Ala Leu Pro Asp Ala Gln Val Pro Gly Leu Gly Arg Pro Arg Gln
                85                  90                  95      
Lys Arg Gln Asp Cys Ser Thr Phe Asp Leu Cys Pro Trp Pro Cys Gly
            100                 105                 110         
Ser Gly His Pro Leu Ala Glu Gln Lys Met Pro Asp Gln His Ile
        115                 120                 125         


<210> 2624
<211> 279
<212> PRT
<213> Homo sapiens

<400> 2624
Met Ala Thr Ser Ser Leu Pro Phe Ala Ile Val Leu Asp Val Leu Pro
 1               5                  10                  15      
Asn Val Gly Thr Glu Leu His Pro Asn Ser Leu Ser Asp Lys Thr Phe
            20                  25                  30          
Thr Ala Glu His Ile Ser Tyr Thr Ser His Ser Ile Asn Tyr Gly Arg
        35                  40                  45              
Thr Arg Val Ser Ser Met Gly Ile His Met Gln Asn Asn Ile Gly Lys
    50                  55                  60                  
Leu Glu Lys Asp Leu Arg Glu Trp Arg Ser Asp Lys Phe Lys Leu Lys
65                  70                  75                  80  
Thr Gln Thr Asn Lys Lys Thr Ser Thr Phe Arg Lys Leu Glu Lys Lys
                85                  90                  95      
Ile Glu Leu Glu Lys Gln Asp Cys Trp His Ser Lys Asp Phe Lys Ile
            100                 105                 110         
Glu Glu Lys Ala Asn Lys Met Leu Lys Val Asp Gln Arg Ala Lys Gln
        115                 120                 125             
Gln Ile Ile Gln Gln Arg Lys Cys Asn Gln Cys Phe Pro Arg Cys Phe
    130                 135                 140                 
Thr Leu Glu Val Lys Cys Val Pro Phe Phe Lys Ala Thr Gln Pro Ser
145                 150                 155                 160 
Leu Thr Gln Trp Glu Thr Cys Gln Glu Gly Ser Asp Leu Leu His Ser
                165                 170                 175     
Gln Phe Ala Gln Arg Gln Ser Ala Lys Ala Ile Pro Ala Gly Phe Ala
            180                 185                 190         
Ile Phe Ala Ile Lys Val Asn Leu Ser Cys Ser Ser Glu Cys Thr Gly
        195                 200                 205             
Gly Met Arg Trp Ala Asp Val Pro Gln Val Ala Ser Asn Ser Gly Thr
    210                 215                 220                 
Trp Gly Arg Leu Leu Cys Arg Gly Gln Arg Val Trp Asn Asn Phe Gln
225                 230                 235                 240 
Glu Ala Ala Arg Gln Glu Val Thr Met Gln Val Cys His Arg Val Gln
                245                 250                 255     
Lys Gly Gln Lys Cys Gln Gly Leu Arg Gly Gly Glu Leu Ser Gln Arg
            260                 265                 270         
Val Ser Leu Leu Ser Val Val
        275                 


<210> 2625
<211> 1057
<212> PRT
<213> Homo sapiens

<400> 2625
Met Ala Ala Lys Asn Ala Gly Arg Val Leu Ala Ser Gln Thr Ser Gln
 1               5                  10                  15      
Glu Asn Gln Ala Ala Pro Ser Pro Ala Asn Gly Thr Met Leu Asn Ser
            20                  25                  30          
Asn Ala Val Gly Ser Val Gly Pro Ser Ser Gly Gln Lys Ile Ala Leu
        35                  40                  45              
Gly Lys Cys Ala Gly Leu Ala Asp Trp Glu His Phe Gly Gly Thr Thr
    50                  55                  60                  
Glu Ser Gln Val Trp Gly Gly Tyr Val Ser Gln Lys Glu Leu Lys Lys
65                  70                  75                  80  
Ser Thr Val Thr Ala Ser Leu Gly Ala Glu Ala His Gly Arg Gln Arg
                85                  90                  95      
Ser Ser Leu Val Arg Ile Gln Asn Lys Lys Val Leu Ser Ser Gly Ser
            100                 105                 110         
Gly Glu Glu Ala Leu Ala Leu Cys Lys Ala Gln Val Ala Ala Pro Arg
        115                 120                 125             
Val Pro Glu Asp Pro Pro Pro Val Arg Lys Phe Ala Leu Pro Leu Pro
    130                 135                 140                 
Ser Pro Pro Lys Gln Val Pro Ala Arg Leu Pro Lys Glu Thr Glu Gly
145                 150                 155                 160 
Arg Ala Glu Glu Glu Pro Arg Thr Val Thr Gln Glu His His Gly Tyr
                165                 170                 175     
Leu Gly Asn Leu Glu Asn Ser Met Gly Cys Lys Gln Asn Ser Lys Ile
            180                 185                 190         
Leu Glu Asp Lys Met Asp Asn Leu Glu His Lys Thr Glu Ala Lys Ala
        195                 200                 205             
Asn Cys Ser Thr Ile Gln Pro Ala Pro Ala Ile Ser Pro His Ala Glu
    210                 215                 220                 
Thr Ser Asp Ser Leu Ser Leu Ala Thr Tyr Thr Leu Gln Val Pro Ala
225                 230                 235                 240 
Pro Pro Ser Thr Leu Asp Leu Ala Glu Pro Ala Thr Arg Pro Arg Cys
                245                 250                 255     
Leu Ser Val Thr Pro Arg Ile Ser Lys Ile Pro Asn Ser Pro Leu Ser
            260                 265                 270         
Leu Pro Thr Asp Leu Val Pro Ile Phe Trp Val Pro Pro Asn Glu Glu
        275                 280                 285             
Gly Gly Ser Ser His Ser Gly Val Ala Ser Ala Ser Pro Thr Ser Asp
    290                 295                 300                 
Pro Leu Thr Pro Ser Pro Thr Pro Phe Ser Phe Arg Pro Pro Phe Arg
305                 310                 315                 320 
Arg Glu Phe Pro Thr Ala Val Tyr Val His Ser Leu Pro Pro Leu Ser
                325                 330                 335     
Ser Pro Ala Leu Leu Pro Gly Pro Ser Thr Arg Ile Ser Val Thr Thr
            340                 345                 350         
Ser Lys Gln Ile Asn Phe Lys Ala Val Ile Phe Thr Ile Thr Ala Asn
        355                 360                 365             
Thr Ser Ala His His Thr Leu Gln Pro Pro Ser Asp Pro Gln Val Leu
    370                 375                 380                 
Asn Arg Asp Thr Thr Phe Pro Pro Lys Ala Val Met Phe Arg Thr Ser
385                 390                 395                 400 
Ser Ser Ser Arg Met Asn Ser Leu Leu Val Ser Gln Ile Asp Gly Ser
                405                 410                 415     
Ala Gln Gln Gly Pro Pro Ala Thr Phe Ile Phe Pro Ser Pro Thr Pro
            420                 425                 430         
Gln Pro Lys Phe Trp Val Pro Asp Leu Ala Lys Ala Asn Cys Ser Thr
        435                 440                 445             
Pro Gln Pro Ala Pro Ala Val Ser Pro Pro Ala Glu Thr Ser Tyr Ser
    450                 455                 460                 
Leu Cys Leu Ala Thr Tyr Thr Ser Gln Val Pro Gly Pro Pro Pro Thr
465                 470                 475                 480 
Pro Asp Leu Gly Ile Ala Ser Ala His Ile Ser Thr Ser Leu Pro Ala
                485                 490                 495     
Gln Pro Val Met Arg Pro Met Thr Thr Ser Asn His Thr Val Asn Leu
            500                 505                 510         
Gly Ala Thr Ala Pro Leu Thr Leu Gly Ala Pro Asn Gly Gln Gln Trp
        515                 520                 525             
Lys Ala Cys Leu Pro Ser Thr Pro Val Ile Leu Ser His Asp Gly Ile
    530                 535                 540                 
Ile Met Ala His Pro Asp Thr Ser Ser Leu Gly Ser Arg Thr Ser Ala
545                 550                 555                 560 
Ala Ser Ser Ser Ile Pro Thr Ile Asp Ser Ser Ala Val Asp Thr Thr
                565                 570                 575     
Leu Ile Glu Lys Leu Ser Ser Ser Ser Leu Pro Leu Ser His Gly Arg
            580                 585                 590         
Ser Val Ser Leu Ser His Leu Ser Leu Leu Gly Ser Gly Asn Thr Asp
        595                 600                 605             
Pro Ser Gly Asn Ile Val Ser Val His Val Ser Thr Ser Leu Pro Ala
    610                 615                 620                 
Gln Ser Val Val Gly Pro Thr Val Thr Ser Asn His Thr Val Asn Gln
625                 630                 635                 640 
Gly Ala Thr Ala Gln Leu Thr Leu Trp Ala Pro Asp Gly Gln Gln Trp
                645                 650                 655     
Lys Ala Ser Leu Leu Asn Gly Phe Leu Arg Leu Pro Arg His Leu Gln
            660                 665                 670         
Phe Arg Lys Gln Lys Lys Cys Ile Leu Ser Tyr Leu Gly Leu Ser Ala
        675                 680                 685             
Ser Thr Asn Lys Gln Leu Asn Arg Asn Thr Ala Ser Val His Ile Ser
    690                 695                 700                 
Thr Ser Leu Pro Ala Gln Ser Val Val Gly Pro Thr Val Thr Ser Asn
705                 710                 715                 720 
His Val Ile His Pro Gly Ala Thr Ala Gln Leu Thr Leu Gly Ala Ser
                725                 730                 735     
Asp Gly Gln His Trp Lys Ala Cys Leu Pro Ser Thr Pro Val Phe Leu
            740                 745                 750         
Ser Leu Pro Met Met Ala Pro Leu Asp Thr Ser Ser Leu Gly Ser Arg
        755                 760                 765             
Thr Ser Ala Ser Ser Ser Ser Ile Pro Thr Ile Gly Ser Ser Thr Val
    770                 775                 780                 
Asp Thr Thr Pro Tyr Ser Lys Ala Val Val Phe Gln Ser Ala Ala Val
785                 790                 795                 800 
Ser Arg Lys Lys Cys Ile Leu Ser Cys Leu Val Phe His Gly Phe Gly
                805                 810                 815     
Asn Thr Glu Pro Ser Gly Asn Ile Val Ser Ala His Ile Phe Thr Asn
            820                 825                 830         
Leu Pro Ala Gln Ser Val Met Gly Pro Ile Pro Thr Ser His Asn Asp
        835                 840                 845             
Asp Lys Ser Asp Arg Ser Phe Ile Leu Gly Asn Pro Ala Thr Pro Ala
    850                 855                 860                 
Pro Val Ile Gly Leu Arg Cys Ser Cys Ser Gln Pro Pro Ser Asp Ser
865                 870                 875                 880 
Thr Met Ala Ala Asp Leu Thr Ser Val Thr Leu Pro Tyr Phe Ala Phe
                885                 890                 895     
Asp Leu Pro Ile Asn Val Gln Pro Gly Pro Gly Gly Ile Met Arg Pro
            900                 905                 910         
Gly Ala Pro Lys His Gly Glu Asn Ile Gly Val Ser Met Ser Leu Gln
        915                 920                 925             
Phe His Ile Lys Asn Thr Glu Asn Tyr Thr Arg Met Glu Gly Asn Asn
    930                 935                 940                 
Gln His Gln Pro Val Pro Pro Phe Gly Gln Val Ala Trp Gly Ser Pro
945                 950                 955                 960 
Ala His Thr Thr Leu Val Val Ala Thr Asn Thr Ser Thr Ile Leu Ala
                965                 970                 975     
Cys Ser Thr Phe Met Pro Asn Thr Trp His Ala Pro Leu Gln Asn Pro
            980                 985                 990         
Gly Val Ala Leu Gly Arg Gly Asn His Ile Pro Ile Val Gly Ala Pro
        995                 1000                1005            
Arg Gly Ser Phe Phe His Gln Ser Met Val Gly Pro Pro Gly Gln Asn
    1010                1015                1020                
Thr Gly Ser Ala Ser Thr Val Asn Ser Thr Ile Ala Ile Met Arg Gly
1025                1030                1035                1040
Leu His Val Pro Ser Gln Gln Pro Ser Ser Gln Gly His Leu Asp Asn
                1045                1050                1055    
Asp
    


<210> 2626
<211> 191
<212> PRT
<213> Homo sapiens

<400> 2626
Met Gly Arg Ile Arg Lys Arg Glu Gly Arg Glu Ile Thr Arg Gln Val
 1               5                  10                  15      
Glu Glu Gln Ala Val Ser Gln Thr Ala Ser Thr Tyr Ser Ile Asn Gln
            20                  25                  30          
Phe Ala Asp Leu Glu Ser Leu Lys Ser Ser Phe Asp Lys Thr Asn Ser
        35                  40                  45              
Leu Lys Cys Glu Lys Ile Val Ile Ala Glu Ser Ser Ser Leu Lys Val
    50                  55                  60                  
Ile Cys Leu Gly Asn Ile Ser Lys Gly Val Arg Leu Asn Lys Glu Val
65                  70                  75                  80  
Tyr Arg Leu Tyr Asp Ala Asn Glu Ser Lys Leu His Asn Met Ile Ser
                85                  90                  95      
Ser Val Ala Lys His Gln Leu Leu Asp Glu Glu Lys Pro Val Met Ser
            100                 105                 110         
Glu Ile Leu Ser Leu Ala Leu Val Ile Thr Thr Tyr Gly Trp His Glu
        115                 120                 125             
Arg Ile Ala Lys Glu Arg Pro Pro Pro Tyr Ala Arg Ser Gly Ala Ser
    130                 135                 140                 
Arg Arg Leu Arg Val Ala Thr Ser Arg Ala Tyr Ala Ala Leu Pro Ala
145                 150                 155                 160 
Ala Ala Leu Thr Cys Gly Ser Cys Ala Arg Asp Val Ala Thr Ala Phe
                165                 170                 175     
Arg Asn Trp Lys Pro Phe Pro His Gln Tyr Phe Glu Val Thr Leu
            180                 185                 190     


<210> 2627
<211> 209
<212> PRT
<213> Homo sapiens

<400> 2627
Met Gly Ser Ala Ala Arg Ala Arg Leu Phe Ser Val Leu Ala Asp Leu
 1               5                  10                  15      
Arg Val Arg Leu Ser Arg Ala Leu Gln Arg Arg Ala Gly Gly Glu Val
            20                  25                  30          
Gln Thr Arg Pro Pro Pro Pro Ser Pro Gly Arg Gly Ser Glu Leu Gly
        35                  40                  45              
Ala Ser Ala Gln Arg Pro Pro Gly Pro Ala Phe Leu Ala Ala Pro Ala
    50                  55                  60                  
Phe Gly Ala Gly Leu Ala Val Gly Arg Leu Arg Arg Val Gly Arg Arg
65                  70                  75                  80  
Gly Pro Glu Lys Arg Gln Pro Gly Arg Asn Pro Pro Ile Asp Pro Leu
                85                  90                  95      
Gly Gly Pro Ala Leu Pro Arg Leu Ser Ser Pro Glu Pro Pro Pro Ala
            100                 105                 110         
Gly Ser Asp Arg Asp Trp Arg Leu Arg Leu Cys Leu Arg Glu Gly Glu
        115                 120                 125             
Gly Val Leu Trp Arg Arg Phe Pro Leu Thr Pro Pro Pro Ser Gly Ser
    130                 135                 140                 
Trp Ala Cys Arg Val Ser Ala Met Gly Glu Gly Cys Ala Arg Cys Leu
145                 150                 155                 160 
Arg Leu Pro Pro Arg Arg Gly Pro Pro Arg Pro Pro Gly Leu Pro Tyr
                165                 170                 175     
Pro Gly Gly Leu Ala Ala Pro Arg Ala Ser Pro Pro Gln His Pro Asn
            180                 185                 190         
Arg Ala Ala Pro Pro Ala Ser Ala Arg Arg Leu Arg Ser Pro Gly Pro
        195                 200                 205             
Ser
    


<210> 2628
<211> 1315
<212> PRT
<213> Homo sapiens

<400> 2628
Met Glu Thr Gly Asp Gly Val Pro Val Ser Ser Arg Val Ser Ala Lys
 1               5                  10                  15      
Ile Gln Gln Leu Val Asn Thr Leu Lys Arg Pro Lys Arg Pro Pro Leu
            20                  25                  30          
Arg Glu Phe Phe Val Asp Asp Phe Glu Glu Leu Leu Glu Val Gln Gln
        35                  40                  45              
Pro Asp Pro Asn Gln Pro Lys Pro Glu Gly Ala Gln Met Leu Ala Met
    50                  55                  60                  
Arg Gly Glu Gln Leu Gly Val Val Thr Asn Trp Pro Pro Ser Leu Glu
65                  70                  75                  80  
Ala Ala Leu Gln Arg Trp Gly Thr Ile Ser Pro Lys Ala Pro Cys Leu
                85                  90                  95      
Thr Thr Met Asp Thr Asn Gly Lys Pro Leu Tyr Ile Leu Thr Tyr Gly
            100                 105                 110         
Lys Leu Trp Thr Arg Ser Met Lys Val Ala Tyr Ser Ile Leu His Lys
        115                 120                 125             
Leu Gly Thr Lys Gln Glu Pro Met Val Arg Pro Gly Asp Arg Val Ala
    130                 135                 140                 
Leu Val Phe Pro Asn Asn Asp Pro Ala Ala Phe Met Ala Ala Phe Tyr
145                 150                 155                 160 
Gly Cys Leu Leu Ala Glu Val Val Pro Val Pro Ile Glu Val Pro Leu
                165                 170                 175     
Thr Arg Lys Asp Ala Gly Ser Gln Gln Ile Gly Phe Leu Leu Gly Ser
            180                 185                 190         
Cys Gly Val Thr Val Ala Leu Thr Ser Asp Ala Cys His Lys Gly Leu
        195                 200                 205             
Pro Lys Ser Pro Thr Gly Glu Ile Pro Gln Phe Lys Gly Trp Pro Lys
    210                 215                 220                 
Leu Leu Trp Phe Val Thr Glu Ser Lys His Leu Ser Lys Pro Pro Arg
225                 230                 235                 240 
Asp Trp Phe Pro His Ile Lys Asp Ala Asn Asn Asp Thr Ala Tyr Ile
                245                 250                 255     
Glu Tyr Lys Thr Cys Lys Asp Gly Ser Val Leu Gly Val Thr Val Thr
            260                 265                 270         
Arg Thr Ala Leu Leu Thr His Cys Gln Ala Leu Thr Gln Ala Cys Gly
        275                 280                 285             
Tyr Thr Glu Ala Glu Thr Ile Val Asn Val Leu Asp Phe Lys Lys Asp
    290                 295                 300                 
Val Gly Leu Trp His Gly Ile Leu Thr Ser Val Met Asn Met Met His
305                 310                 315                 320 
Val Ile Ser Ile Pro Tyr Ser Leu Met Lys Val Asn Pro Leu Ser Trp
                325                 330                 335     
Ile Gln Lys Val Cys Gln Tyr Lys Ala Lys Val Ala Cys Val Lys Ser
            340                 345                 350         
Arg Asp Met His Trp Ala Leu Val Ala His Arg Asp Gln Arg Asp Ile
        355                 360                 365             
Asn Leu Ser Ser Leu Arg Met Leu Ile Val Ala Asp Gly Ala Asn Pro
    370                 375                 380                 
Trp Ser Ile Ser Ser Cys Asp Ala Phe Leu Asn Val Phe Gln Ser Lys
385                 390                 395                 400 
Gly Leu Arg Gln Glu Val Ile Cys Pro Cys Ala Ser Ser Pro Glu Ala
                405                 410                 415     
Leu Thr Val Ala Ile Arg Arg Pro Thr Asp Asp Ser Asn Gln Pro Pro
            420                 425                 430         
Gly Arg Gly Val Leu Ser Met His Gly Leu Thr Tyr Gly Val Ile Arg
        435                 440                 445             
Val Asp Ser Glu Glu Lys Leu Ser Val Leu Thr Val Gln Asp Val Gly
    450                 455                 460                 
Leu Val Met Pro Gly Ala Ile Met Cys Ser Val Lys Pro Asp Gly Val
465                 470                 475                 480 
Pro Gln Leu Cys Arg Thr Asp Glu Ile Gly Glu Leu Cys Val Cys Ala
                485                 490                 495     
Val Ala Thr Gly Thr Ser Tyr Tyr Gly Leu Ser Gly Met Thr Lys Asn
            500                 505                 510         
Thr Phe Glu Val Phe Pro Met Thr Ser Ser Gly Ala Pro Ile Ser Glu
        515                 520                 525             
Tyr Pro Phe Ile Arg Thr Gly Leu Leu Gly Phe Val Gly Pro Gly Gly
    530                 535                 540                 
Leu Val Phe Val Val Gly Lys Met Asp Gly Leu Met Val Val Ser Gly
545                 550                 555                 560 
Arg Arg His Asn Ala Asp Asp Ile Val Ala Thr Ala Leu Ala Val Glu
                565                 570                 575     
Pro Met Lys Phe Val Tyr Arg Gly Arg Ile Ala Val Phe Ser Val Thr
            580                 585                 590         
Val Leu His Asp Glu Arg Ile Val Ile Val Ala Glu Gln Arg Pro Asp
        595                 600                 605             
Ser Thr Glu Glu Asp Ser Phe Gln Trp Met Ser Arg Val Leu Gln Ala
    610                 615                 620                 
Ile Asp Ser Ile His Gln Val Gly Val Tyr Cys Leu Ala Leu Val Pro
625                 630                 635                 640 
Ala Asn Thr Leu Pro Lys Thr Pro Leu Gly Gly Ile His Leu Ser Glu
                645                 650                 655     
Thr Lys Gln Leu Phe Leu Glu Gly Ser Leu His Pro Cys Asn Val Leu
            660                 665                 670         
Met Cys Pro His Thr Cys Val Thr Asn Leu Pro Lys Pro Arg Gln Lys
        675                 680                 685             
Gln Pro Glu Ile Gly Pro Ala Ser Val Met Val Gly Asn Leu Val Ser
    690                 695                 700                 
Gly Lys Arg Ile Ala Gln Ala Ser Gly Arg Asp Leu Gly Gln Ile Glu
705                 710                 715                 720 
Asp Asn Asp Gln Ala Arg Lys Phe Leu Phe Leu Ser Glu Val Leu Gln
                725                 730                 735     
Trp Arg Ala Gln Thr Thr Pro Asp His Ile Leu Tyr Thr Leu Leu Asn
            740                 745                 750         
Cys Arg Gly Ala Ile Ala Asn Ser Leu Thr Cys Val Gln Leu His Lys
        755                 760                 765             
Arg Ala Glu Lys Ile Ala Val Met Leu Met Glu Arg Gly His Leu Gln
    770                 775                 780                 
Asp Gly Asp His Val Ala Leu Val Tyr Pro Pro Gly Ile Asp Leu Ile
785                 790                 795                 800 
Ala Ala Phe Tyr Gly Cys Leu Tyr Ala Gly Cys Val Pro Ile Thr Val
                805                 810                 815     
Arg Pro Pro His Pro Gln Asn Ile Ala Thr Thr Leu Pro Thr Val Lys
            820                 825                 830         
Met Ile Val Glu Val Ser Arg Ser Ala Cys Leu Met Thr Thr Gln Leu
        835                 840                 845             
Ile Cys Lys Leu Leu Arg Ser Arg Glu Ala Ala Ala Ala Val Asp Val
    850                 855                 860                 
Arg Thr Trp Pro Leu Ile Leu Asp Thr Asp Asp Leu Pro Lys Lys Arg
865                 870                 875                 880 
Pro Ala Gln Ile Cys Lys Pro Cys Asn Pro Asp Thr Leu Ala Tyr Leu
                885                 890                 895     
Asp Phe Ser Val Ser Thr Thr Gly Met Leu Ala Gly Val Lys Met Ser
            900                 905                 910         
His Ala Ala Thr Ser Ala Phe Cys Arg Ser Ile Lys Leu Gln Cys Glu
        915                 920                 925             
Leu Tyr Pro Ser Arg Glu Val Ala Ile Cys Leu Asp Pro Tyr Cys Gly
    930                 935                 940                 
Leu Gly Phe Val Leu Trp Cys Leu Cys Ser Val Tyr Ser Gly His Gln
945                 950                 955                 960 
Ser Ile Leu Ile Pro Pro Ser Glu Leu Glu Thr Asn Pro Ala Leu Trp
                965                 970                 975     
Leu Leu Ala Val Ser Gln Tyr Lys Val Arg Asp Thr Phe Cys Ser Tyr
            980                 985                 990         
Ser Val Met Glu Leu Cys Thr Lys Gly Leu Gly Ser Gln Thr Glu Ser
        995                 1000                1005            
Leu Lys Ala Arg Gly Leu Asp Leu Ser Arg Val Arg Thr Cys Val Val
    1010                1015                1020                
Val Ala Glu Glu Arg Pro Arg Ile Ala Leu Thr Gln Ser Phe Ser Lys
1025                1030                1035                1040
Leu Phe Lys Asp Leu Gly Leu His Pro Arg Ala Val Ser Thr Ser Phe
                1045                1050                1055    
Gly Cys Arg Val Asn Leu Ala Ile Cys Leu Gln Gly Thr Ser Gly Pro
            1060                1065                1070        
Asp Pro Thr Thr Val Tyr Val Asp Met Arg Ala Leu Arg His Asp Arg
        1075                1080                1085            
Val Arg Leu Val Glu Arg Gly Ser Pro His Ser Leu Pro Leu Met Glu
    1090                1095                1100                
Ser Gly Lys Ile Leu Pro Gly Val Arg Ile Ile Ile Ala Asn Pro Glu
1105                1110                1115                1120
Thr Lys Gly Pro Leu Gly Asp Ser His Leu Gly Glu Ile Trp Val His
                1125                1130                1135    
Ser Ala His Asn Ala Ser Gly Tyr Phe Thr Ile Tyr Gly Asp Glu Ser
            1140                1145                1150        
Leu Gln Ser Asp His Phe Asn Ser Arg Leu Ser Phe Gly Asp Thr Gln
        1155                1160                1165            
Thr Ile Trp Ala Arg Thr Gly Tyr Leu Gly Phe Leu Arg Arg Thr Glu
    1170                1175                1180                
Leu Thr Asp Ala Asn Gly Glu Arg His Asp Ala Leu Tyr Val Val Gly
1185                1190                1195                1200
Ala Leu Asp Glu Ala Met Glu Leu Arg Gly Met Arg Tyr His Pro Ile
                1205                1210                1215    
Asp Ile Glu Thr Ser Val Ile Arg Ala His Lys Ser Val Thr Glu Cys
            1220                1225                1230        
Ala Val Phe Thr Trp Thr Asn Leu Leu Val Val Val Val Glu Leu Asp
        1235                1240                1245            
Gly Ser Glu Gln Glu Ala Leu Asp Leu Val Pro Leu Val Thr Asn Val
    1250                1255                1260                
Val Leu Glu Glu His Tyr Leu Ile Val Gly Val Val Val Val Val Asp
1265                1270                1275                1280
Ile Gly Val Ile Pro Ile Asn Ser Arg Gly Glu Lys Gln Arg Met His
                1285                1290                1295    
Leu Arg Asp Gly Phe Leu Ala Asp Gln Leu Asp Pro Ile Tyr Val Ala
            1300                1305                1310        
Tyr Asn Met
        1315


<210> 2629
<211> 431
<212> PRT
<213> Homo sapiens

<400> 2629
Met Ser Ile Arg Val Thr Gln Lys Ser Tyr Lys Val Ser Thr Ser Glu
 1               5                  10                  15      
Pro Arg Ala Phe Ser Ser His Phe Tyr Thr Met Gly Ser Ser Ser Phe
            20                  25                  30          
Arg Gly Gly Leu Gly Arg Gly Tyr Gly Gly Ala Ser Gly Ile Gly Gly
        35                  40                  45              
Ile Thr Thr Val Thr Val Asn Gln Ser Leu Leu Ser Pro Leu Asn Leu
    50                  55                  60                  
Glu Val Asp Pro Asn Ile Gln Ala Val Arg Thr Gln Glu Lys Glu Gln
65                  70                  75                  80  
Ile Lys Thr Leu Asn Asn Lys Phe Ala Ser Phe Thr Asp Lys Ile Arg
                85                  90                  95      
Phe Leu Glu Gln Gln Asn Lys Met Leu Glu Thr Lys Trp Ser Leu Leu
            100                 105                 110         
Gln Gln Gln Lys Met Ala Gln Ser Asn Met Asp Asn Met Phe Gly Ser
        115                 120                 125             
Tyr Ile Asn Asn Leu Thr Gln Gln Leu Glu Thr Leu Gly Gln Glu Lys
    130                 135                 140                 
Leu Lys Leu Glu Val Glu Leu Gly Asn Met Gln Gly Leu Val Glu Asp
145                 150                 155                 160 
Phe Lys Asn Lys Tyr Glu Asp Glu Ile His Lys Leu Thr Glu Met Glu
                165                 170                 175     
Asn Glu Phe Val Leu Ile Lys Lys Glu Val Asp Glu Ala Tyr Met Asn
            180                 185                 190         
Lys Val Glu Leu Gly Ser Arg Leu Glu Gly Leu Thr Asp Glu Ile Asn
        195                 200                 205             
Phe Leu Arg Gln Leu Tyr Glu Glu Glu Ile Arg Glu Leu Gln Cys Gln
    210                 215                 220                 
Ile Ser Asp Thr Ser Ala Pro Ser Leu Asp Met Asp Ser Ile Ile Ala
225                 230                 235                 240 
Glu Val Lys Val Gln Tyr Glu Glu Ile Thr Asn His Ser Gln Ala Glu
                245                 250                 255     
Ala Glu Ser Met Tyr Gln Ile Lys Tyr Glu Glu Leu Gln Thr Leu Val
            260                 265                 270         
Gly Lys His Gly Asn Asp Leu Arg Arg Thr Lys Thr Glu Ile Ser Glu
        275                 280                 285             
Met Asn Arg Asn Ile Ser Arg Leu Gln Ala Glu Ala Glu Gly Leu Lys
    290                 295                 300                 
Gly Gln Arg Thr Ser Leu Glu Ala Ala Ile Ala Asp Ala Gln Gln Arg
305                 310                 315                 320 
Gly Glu Leu Ala Val Lys Asp Ala Asn Ala Glu Leu Ser Glu Leu Glu
                325                 330                 335     
Ala Ala Gln Glu Arg Ala Lys Gln Asp Met Ala Arg Pro Leu Arg Glu
            340                 345                 350         
Tyr Gln Glu Leu Met Asn Val Lys Leu Ala Leu Asp Ile Gln Ile Ala
        355                 360                 365             
Thr Tyr Arg Lys Leu Leu Glu Gly Asp Glu Ser Arg Leu Glu Ser Gly
    370                 375                 380                 
Met Leu Asn Met Ser Ile His Thr Lys Thr Thr Ser Ser Tyr Ala Ala
385                 390                 395                 400 
Pro Phe Ser Ser Thr Gly Ser Thr Arg Ala Val Val Val Lys Lys Ile
                405                 410                 415     
Lys Thr Arg Asp Gly Lys Leu Glu Ser Ser Asp Val Leu Pro Lys
            420                 425                 430     


<210> 2630
<211> 464
<212> PRT
<213> Homo sapiens

<400> 2630
Met Leu Ala Thr Arg Arg Leu Leu Gly Trp Ser Leu Pro Ala Arg Val
 1               5                  10                  15      
Ser Val Arg Phe Ser Gly Asp Thr Thr Ala Pro Lys Lys Thr Ser Phe
            20                  25                  30          
Gly Ser Leu Lys Asp Glu Asp Arg Ile Phe Thr Asn Leu Tyr Gly Arg
        35                  40                  45              
His Asp Trp Arg Leu Lys Gly Ser Leu Ser Arg Gly Asp Trp Tyr Lys
    50                  55                  60                  
Thr Lys Glu Ile Leu Leu Lys Gly Pro Asp Trp Ile Leu Gly Glu Ile
65                  70                  75                  80  
Lys Thr Ser Gly Leu Arg Gly Arg Gly Gly Ala Gly Phe Pro Thr Gly
                85                  90                  95      
Leu Lys Trp Ser Phe Met Asn Lys Pro Ser Asp Gly Arg Pro Lys Tyr
            100                 105                 110         
Leu Val Val Asn Ala Asp Glu Gly Glu Pro Gly Thr Cys Lys Asp Arg
        115                 120                 125             
Glu Ile Leu Arg His Asp Pro His Lys Leu Leu Glu Gly Cys Leu Val
    130                 135                 140                 
Gly Gly Arg Ala Met Gly Ala Arg Ala Ala Tyr Ile Tyr Ile Arg Gly
145                 150                 155                 160 
Glu Phe Tyr Asn Glu Ala Ser Asn Leu Gln Val Ala Ile Arg Glu Ala
                165                 170                 175     
Tyr Glu Ala Gly Leu Ile Gly Lys Asn Ala Cys Gly Ser Gly Tyr Asp
            180                 185                 190         
Phe Asp Val Phe Val Val Arg Gly Ala Gly Ala Tyr Ile Cys Gly Glu
        195                 200                 205             
Glu Thr Ala Leu Ile Glu Ser Ile Glu Gly Lys Gln Gly Lys Pro Arg
    210                 215                 220                 
Leu Lys Pro Pro Phe Pro Ala Asp Val Gly Val Phe Gly Cys Pro Thr
225                 230                 235                 240 
Thr Val Ala Asn Val Glu Thr Val Ala Val Ser Pro Thr Ile Cys Arg
                245                 250                 255     
Arg Gly Gly Thr Trp Phe Ala Gly Phe Gly Arg Glu Arg Asn Ser Gly
            260                 265                 270         
Thr Lys Leu Phe Asn Ile Ser Gly His Val Asn His Pro Cys Thr Val
        275                 280                 285             
Glu Glu Glu Met Ser Val Pro Leu Lys Glu Leu Ile Glu Lys His Ala
    290                 295                 300                 
Gly Gly Val Thr Gly Gly Trp Asp Asn Leu Leu Ala Val Ile Pro Gly
305                 310                 315                 320 
Gly Ser Ser Thr Pro Leu Ile Pro Lys Ser Val Cys Glu Thr Val Leu
                325                 330                 335     
Met Asp Phe Asp Ala Leu Val Gln Ala Gln Thr Gly Leu Gly Thr Ala
            340                 345                 350         
Ala Val Ile Val Met Asp Arg Ser Thr Asp Ile Val Lys Ala Ile Ala
        355                 360                 365             
Arg Leu Ile Glu Phe Tyr Lys His Glu Ser Cys Gly Gln Cys Thr Pro
    370                 375                 380                 
Cys Arg Glu Gly Val Asp Trp Met Asn Lys Val Met Ala Arg Phe Val
385                 390                 395                 400 
Arg Gly Asp Ala Arg Pro Ala Glu Ile Asp Ser Leu Trp Glu Ile Ser
                405                 410                 415     
Lys Gln Ile Glu Gly His Thr Ile Cys Ala Leu Gly Asp Gly Ala Ala
            420                 425                 430         
Trp Pro Val Gln Gly Leu Ile Arg His Phe Arg Pro Glu Leu Glu Glu
        435                 440                 445             
Arg Met Gln Arg Phe Ala Gln Gln His Gln Ala Arg Gln Ala Ala Ser
    450                 455                 460                 


<210> 2631
<211> 207
<212> PRT
<213> Homo sapiens

<400> 2631
Met Ala Leu Leu Phe Ala Arg Ser Leu Arg Leu Cys Arg Trp Gly Ala
 1               5                  10                  15      
Lys Arg Leu Gly Val Ala Ser Thr Glu Ala Gln Arg Gly Val Ser Phe
            20                  25                  30          
Lys Leu Glu Glu Lys Thr Ala His Ser Ser Leu Ala Leu Phe Arg Asp
        35                  40                  45              
Asp Thr Gly Val Lys Tyr Gly Leu Val Gly Leu Glu Pro Thr Lys Val
    50                  55                  60                  
Ala Leu Asn Val Glu Arg Phe Arg Glu Trp Ala Val Val Leu Ala Asp
65                  70                  75                  80  
Thr Ala Val Thr Ser Gly Arg His Tyr Trp Glu Val Thr Val Lys Arg
                85                  90                  95      
Ser Gln Gln Phe Arg Ile Gly Val Ala Asp Val Asp Met Ser Arg Asp
            100                 105                 110         
Ser Cys Ile Gly Val Asp Asp Arg Ser Trp Val Phe Thr Tyr Ala Gln
        115                 120                 125             
Arg Lys Trp Tyr Thr Met Leu Ala Asn Glu Lys Ala Pro Val Glu Gly
    130                 135                 140                 
Ile Gly Gln Pro Glu Lys Val Gly Leu Leu Leu Glu Tyr Glu Ala Gln
145                 150                 155                 160 
Lys Leu Ser Leu Val Asp Val Ser Gln Val Ser Val Val His Thr Leu
                165                 170                 175     
Gln Thr Asp Phe Arg Gly Pro Val Val Pro Ala Phe Ala Leu Trp Asp
            180                 185                 190         
Gly Glu Leu Leu Thr His Ser Gly Leu Glu Val Pro Glu Gly Leu
        195                 200                 205         


<210> 2632
<211> 533
<212> PRT
<213> Homo sapiens

<400> 2632
Met Pro Phe Thr Gly Arg Gly Lys Lys Glu Ser Phe Gln Leu Leu Gln
 1               5                  10                  15      
His Ile Arg Ile Ala Asn Arg Pro Glu Arg Leu Pro Ser Gln Leu Arg
            20                  25                  30          
Gly Ser Arg Gly Lys Gly Lys Pro Arg Ser Arg Ser Trp Gly Gly Ala
        35                  40                  45              
His Ser Ala Pro Pro Gly Thr Gly Asn Lys Met Ala Gly Pro Met Gly
    50                  55                  60                  
Arg Gln Arg Pro Ser His Ser Ala Tyr Arg Gly Arg Pro Gly Cys Cys
65                  70                  75                  80  
Leu Ser Asn Val Thr Val Leu Leu Ser Ala Leu Thr Ile Met Ala Thr
                85                  90                  95      
Leu Thr Thr Ser Val Leu Leu Phe Thr Gln Thr Val Val Ser Lys Ala
            100                 105                 110         
Thr Leu Ser Trp Lys Phe Leu Trp Ser Val Phe Leu Glu Ile Arg His
        115                 120                 125             
His Leu Leu Thr Thr Thr Thr Trp Ala Arg Ala Gln Val His Leu Val
    130                 135                 140                 
Asp Val Pro Val Arg Gly Gln Asp Ser Val Ala Gly Thr Tyr Pro Ser
145                 150                 155                 160 
Ser Phe Arg Glu Arg Thr Leu His Met Val Leu Ser Gly His Leu Trp
                165                 170                 175     
Pro Thr Gly Thr Gly Lys Trp Ser Gln Ser Cys Glu Ala Leu Arg Ser
            180                 185                 190         
His Gly Gly Pro Ala Ala Thr Thr Lys Tyr Ile Leu Ser Cys Cys Trp
        195                 200                 205             
Pro Thr Cys Gly Gln Leu Gly Ser Thr Thr Ser Asn Val Gln Asn Pro
    210                 215                 220                 
Gly Thr Arg Val Ser Tyr Pro Val Tyr Thr Leu Gly Asp Pro Gly Met
225                 230                 235                 240 
His Cys Cys Val Gly Leu Tyr Glu Gln Glu Ile Thr Tyr Gly Asp Lys
                245                 250                 255     
Lys Gly Arg Ala Gly Arg Lys Arg Phe Asn Pro Gly Thr Ile Pro Thr
            260                 265                 270         
Cys Cys Thr Ala Gln Trp Arg Ser Ser Gly Ala Asn Arg Asp Asp Leu
        275                 280                 285             
Asn Asp Ser Thr Asp Cys Trp Arg Pro Ala Glu Met Pro Asp Gln Glu
    290                 295                 300                 
Ile Ala Arg Trp Lys Gln Arg Leu Glu Gln Ala Lys Ala Glu Met Lys
305                 310                 315                 320 
Gln Ala Thr Asp Val Gly Val Arg Gln Leu Thr Ser Leu Ala His Asn
                325                 330                 335     
Pro Gln Ser Asn Leu His Leu Leu Glu Gly Gly Arg Asp His Lys Tyr
            340                 345                 350         
Leu Gln Leu Val Ala Ala Ala Glu Pro Ala Ala Thr Ala Ser Glu Gln
        355                 360                 365             
Lys Met Ala Val Pro Leu Thr Tyr Ala Asn Leu Gly Lys Ser Ala Arg
    370                 375                 380                 
Asp Val Phe Thr Lys Gly Tyr Gly Phe Gly Leu Ile Lys Leu Asp Leu
385                 390                 395                 400 
Lys Thr Lys Ser Glu Asn Gly Leu Glu Phe Thr Ser Ser Asp Ser Ala
                405                 410                 415     
Asn Thr Val Ala Thr Lys Lys Trp Asn Thr Asp Asn Thr Leu Gly Thr
            420                 425                 430         
Gln Ile Thr Val Glu Asp Gln Leu Ala Arg Val Leu Lys Leu Thr Phe
        435                 440                 445             
Asp Ser Ser Phe Ser Pro Asn Thr Gly Gly Lys Lys Ala Lys Ile Lys
    450                 455                 460                 
Thr Gly Tyr Lys Trp Glu His Ile Asn Leu Gly Cys Asp Met Asp Phe
465                 470                 475                 480 
Asp Ile Ala Gly Pro Ser Ile Gln Cys Ala Leu Val Leu Gly Tyr Gly
                485                 490                 495     
Gly Trp Leu Ala Asn Tyr Gln Met Asn Phe Glu Thr Ala Lys Ser Arg
            500                 505                 510         
Val Thr Gln Ser Asn Phe Ala Val Gly Tyr Lys Thr Asp Glu Phe Gln
        515                 520                 525             
Leu His Thr Asn Val
    530             


<210> 2633
<211> 381
<212> PRT
<213> Homo sapiens

<400> 2633
Met Leu Val Trp Gly Gln Arg Leu Pro Arg Glu Gly Val Ser Asn Gly
 1               5                  10                  15      
Glu His Val Ser Glu Ser Thr Ala Ser Met Lys Lys His His Asn Glu
            20                  25                  30          
Glu His Val Ser Glu Ser Met Ala Ser Met Gly Lys His Cys Asn Glu
        35                  40                  45              
Glu His Val Ser Glu Ser Thr Ala Ser Met Arg Arg His His Asn Glu
    50                  55                  60                  
Glu His Val Ser Glu Ser Thr Ala Ser Met Arg Lys His His Asn Glu
65                  70                  75                  80  
Glu His Val Leu Glu Ser Met Ala Ser Met Arg Lys His His Asn Glu
                85                  90                  95      
Glu His Val Ser Glu Ser Thr Ala Ser Met Gly Lys His Arg Asn Glu
            100                 105                 110         
Glu His Val Ser Glu Ser Thr Ala Ser Met Arg Arg Tyr His Asn Glu
        115                 120                 125             
Glu His Val Ser Glu Ser Thr Ala Ser Met Arg Lys His His Asn Glu
    130                 135                 140                 
Glu His Val Ser Glu Ser Thr Ala Ser Met Gly Lys His His Asn Glu
145                 150                 155                 160 
Glu His Val Ser Glu Ser Thr Ala Ser Met Gly Lys His His Asn Glu
                165                 170                 175     
Glu His Val Ser Glu Ser Thr Ala Ser Met Gly Lys His Arg Asn Glu
            180                 185                 190         
Glu His Val Ser Glu Ser Met Ala Ser Met Gly Lys His His Asn Glu
        195                 200                 205             
Glu His Val Ser Glu Ser Met Ala Ser Met Gly Lys His His Asn Glu
    210                 215                 220                 
Glu His Val Ser Glu Ser Thr Ala Ser Met Gly Lys His His Asn Glu
225                 230                 235                 240 
Glu His Val Leu Glu Ser Met Ala Ser Met Gly Lys His His Asn Glu
                245                 250                 255     
Glu His Val Leu Glu Ser Met Ala Ser Met Gly Lys His His Asn Glu
            260                 265                 270         
Asp His Val Leu Glu Ser Met Ala Ser Met Gly Lys His His Asn Glu
        275                 280                 285             
Glu His Val Ser Glu Ser Thr Ala Ser Met Gly Lys His His Asn Glu
    290                 295                 300                 
Glu His Val Ser Glu Ser Thr Ala Ser Met Gly Lys His His Asn Glu
305                 310                 315                 320 
Glu His Val Leu Glu Ser Met Ala Ser Val Gly Lys His His Asn Glu
                325                 330                 335     
Glu His Val Leu Glu Ser Met Ala Ser Met Gly Lys His His Asn Glu
            340                 345                 350         
Glu His Val Ser Glu Ser Thr Ala Ser Met Gly Lys His His Asn Glu
        355                 360                 365             
Glu His Ala Ser His Ala Ile Met Ala Pro Phe Leu Leu
    370                 375                 380     


<210> 2634
<211> 165
<212> PRT
<213> Homo sapiens

<400> 2634
Met Ser Leu Leu Leu Lys Lys Lys Thr Thr Ala Thr Gly Glu Trp Thr
 1               5                  10                  15      
Trp Leu Glu Arg Lys Thr Lys Gly Arg Glu Pro Glu Pro Val Gly Val
            20                  25                  30          
Leu Met Glu Arg Ser Trp Gly Ala Glu Lys Lys Ser Arg Lys Asn Leu
        35                  40                  45              
Ala Glu Asn Asn Pro Leu Arg Asn Ser Lys Pro His Arg Lys Ala Ser
    50                  55                  60                  
Pro Leu Leu Lys Val Ser Leu His Tyr Leu Gly Leu Gln Glu Glu Gln
65                  70                  75                  80  
Gly Ser Thr Thr Ser Leu His Arg Asn Thr Glu Gln Gln His Pro Ser
                85                  90                  95      
Asn Lys Glu Gln Thr Ser His Arg Val Val His Arg Gly Leu Asp Glu
            100                 105                 110         
Glu Ala Leu Pro Gly Ala His Phe Gly Gly Gly His Arg Arg Gly Val
        115                 120                 125             
Leu Cys Ser Leu His Tyr Cys Ser Pro Ile Thr Asn Leu Leu Thr Leu
    130                 135                 140                 
Asn Leu Arg Tyr His Trp Gly His Val Arg Asn Ser Glu Ser Leu Gln
145                 150                 155                 160 
Cys Tyr Gln Gln Val
                165 


<210> 2635
<211> 180
<212> PRT
<213> Homo sapiens

<400> 2635
Met Phe Ala Gly Arg Glu Ala Ser Glu Asp Ala Glu Gly Gly Leu Arg
 1               5                  10                  15      
Leu Thr Ser Ala Ser Val Ser Gly Thr Phe Pro Ser Pro Thr Ser His
            20                  25                  30          
Arg Arg Arg Ser Pro Gly Lys Thr Ala Leu Ala Asp Pro Pro Gly Val
        35                  40                  45              
Trp Ala Ser Ser His Ile Arg Gly Pro Leu Arg Gly Arg Ala Pro Thr
    50                  55                  60                  
Glu Gly Ala Ala Ala Arg Leu Ala Phe Pro Pro Leu Gln Leu Glu Pro
65                  70                  75                  80  
Ser Thr Lys Val His Ala Ala Val Asp Ala Leu Ala Val Arg Arg Ala
                85                  90                  95      
Arg Ser Pro Asp Pro Arg Gly Arg Pro Pro Gly Pro Leu Leu Ser His
            100                 105                 110         
Arg His Arg Arg Cys Arg Gln Leu Pro Ala Ala Glu Glu Gly Ala Pro
        115                 120                 125             
Asp Gly Ala Gly Arg Gly Glu Arg Pro Pro Leu Gly Asp Leu Ala Ile
    130                 135                 140                 
Val Arg Arg Gln Glu Lys Glu Arg Lys Val Leu Gln Gly Ser Gly Ser
145                 150                 155                 160 
Gln Pro Ser His Arg Pro Ser Val Thr Ala Tyr Ser Pro Gly Ala Ser
                165                 170                 175     
Pro Val Leu Asp
            180 


<210> 2636
<211> 698
<212> PRT
<213> Homo sapiens

<400> 2636
Met Gly Tyr Asn Phe Thr Ser Arg Cys Val His Gln Lys Pro Pro Cys
 1               5                  10                  15      
Cys Pro Leu Trp Pro Ser Pro Pro Gly Ala Ser Gly Ala Glu Val Pro
            20                  25                  30          
Lys Gly Tyr Leu Ala Cys Gly Val Arg Leu Ser Pro Lys Pro Gly Trp
        35                  40                  45              
Lys Thr Trp Gly Ser Pro Gln Ser Gln Ala Thr Ala Leu Ile Ser Gly
    50                  55                  60                  
Thr Ile Pro Gly Gln Asp Ser Gly Pro Ser Gly Gly Ala Arg Asp Ala
65                  70                  75                  80  
Ala Glu Arg Pro Thr Thr Pro Arg Ser His Leu Pro Arg His Ser Ser
                85                  90                  95      
Ser Val Lys Tyr Leu Leu Gly Ala Arg Phe Gly Trp Pro Ser Leu Ser
            100                 105                 110         
Pro Pro Leu Ile Ser Pro Cys Gln Gly Val Leu Cys His Leu Gly Ala
        115                 120                 125             
Arg Gly Ser Cys Gly Gly Phe Ser Ala Leu Gln Gly Glu Ala Cys Ala
    130                 135                 140                 
Leu Arg Ala Asp Gly Pro Arg Leu Thr Leu Gln Ala Lys Lys Ser Pro
145                 150                 155                 160 
Ser Ser Ala Trp Leu Pro Thr Leu Pro Thr Leu Ala Ala Gly Ser Val
                165                 170                 175     
Trp Arg Thr Ser Pro Ala Pro Pro Ala Ala Ile Leu Arg Gly Met Val
            180                 185                 190         
Ser Leu Gly Pro Asn Gly Leu Gln Leu Pro Met Glu Ala Leu Pro Arg
        195                 200                 205             
Thr Thr Gln Pro Gly Gly His Cys Gly Pro Thr Pro Gln Met Arg Lys
    210                 215                 220                 
Gln Ala Arg Glu Glu Asp Ala Thr Gly Pro Gly Ser Trp Glu Trp Glu
225                 230                 235                 240 
Gly Pro Gly His Arg Glu Cys Gly Cys Gly Phe Arg Pro Leu Gly Pro
                245                 250                 255     
Arg Ile Pro Val Ser Val Gly Gly Ala Val Val His Thr Lys Gly Gly
            260                 265                 270         
Leu Gln Arg Glu Val Arg Thr Leu Gly Leu Pro Pro Gly Gln Pro Ser
        275                 280                 285             
Leu Ser Lys Ser Pro Pro Ala Ala Glu Leu Pro Pro Val Lys Pro Leu
    290                 295                 300                 
Phe Pro Ala Phe Cys Ala Leu Asn Lys Leu Leu Leu Gly Leu Ser His
305                 310                 315                 320 
Gln His Ser Val Val Gly Val Ala Ala Ala Arg Leu Pro Ser Cys Thr
                325                 330                 335     
Gln Ala Pro His Ser Thr His Thr Ile Ala Pro Gln Tyr Leu Gln Asp
            340                 345                 350         
Gln Thr Gln Ala Val Val Val Ala Thr Thr Ser Ile Glu Pro Thr Pro
        355                 360                 365             
Arg Gln Ala Met Ser Gly Tyr Leu Gln Val Cys Ala Asp Thr Pro Gly
    370                 375                 380                 
Thr Cys Arg Asp Leu Ile Val Ile Ala Gly Leu Glu Val Ala Leu Ser
385                 390                 395                 400 
Ser Ala Phe Glu Lys Pro Asn Cys Val Ile Leu Phe Pro Glu Thr Leu
                405                 410                 415     
Gln Cys Ser Ser Glu Gln Pro Pro Gln Pro Thr Gly Leu Cys Pro Ser
            420                 425                 430         
Cys Pro Leu Tyr Cys Ala Ala Ile Thr Arg Pro Thr Leu His Arg Ser
        435                 440                 445             
Phe Thr Leu Gly Ala Thr Asp Ser Lys Tyr Pro Phe Ile Leu Met Ala
    450                 455                 460                 
Pro Lys Pro Asn Gln Val Ile Glu Thr Ile Gln Asn Leu Thr His Gln
465                 470                 475                 480 
Glu Gly Phe Gln Ala Asp Ala Ser Trp Ser Pro Asp Arg Gln Gln Asp
                485                 490                 495     
Asn Asn Ile Ala Ala Glu Gln Gly Pro Gly Ser Phe Val Glu Pro Pro
            500                 505                 510         
Leu Cys Thr Leu Gly Pro Gly Phe Phe Gly Asp Ala Ala Val Arg Ala
        515                 520                 525             
Val Ala Lys Gln Asn Gln Gln Thr Gln Ser Gln Gly Pro Asn Ser Lys
    530                 535                 540                 
Asp Ala Ala Gly Asp Pro Gly Ser Ser Gly Pro Phe Pro Ser Glu Pro
545                 550                 555                 560 
Gln Ser Gln Gln Pro Cys Ser Leu Trp Ala Gln Leu Gly Ala Ala Pro
                565                 570                 575     
Lys Cys Gly Glu Gln Ala Leu Pro Arg Gln Ser Pro Ala His Ala Ser
            580                 585                 590         
Glu Pro Gly Val Pro Gln Ala His Cys Pro Pro Gly Leu Gly Arg Pro
        595                 600                 605             
Arg Ser Gln Pro Gln Thr Cys Gln Gln Glu Glu Gln Arg Val Glu Ala
    610                 615                 620                 
Val Gly Arg Leu Ala Val Gly Gly Pro Arg Phe Met Ala Val Gln Asp
625                 630                 635                 640 
Thr Ala Gly Ser Arg Asn Leu Ala Ala Arg Thr Asp Leu Ala Gln Tyr
                645                 650                 655     
Asn Gly Glu Ala Asp Gly Arg Thr Pro Ala Gly Val Arg Glu Thr Val
            660                 665                 670         
Pro Leu Val His Thr Ile Ala His Leu His Gly Phe Leu Glu Ser Thr
        675                 680                 685             
Ala Ala Val Leu Asn Asn Arg His Pro Glu
    690                 695             


<210> 2637
<211> 896
<212> PRT
<213> Homo sapiens

<400> 2637
Met Glu Ser Leu Lys Thr Asp Thr Glu Met Pro Tyr Pro Glu Val Ile
 1               5                  10                  15      
Val Asp Val Gly Arg Val Ile Phe Gly Glu Glu Asn Arg Lys Lys Met
            20                  25                  30          
Thr Asn Ser Cys Leu Lys Arg Ser Glu Asn Ser Arg Ile Ile Arg Ala
        35                  40                  45              
Ile Cys Ala Leu Leu Asn Ser Gly Gly Gly Val Ile Lys Ala Glu Ile
    50                  55                  60                  
Asp Asp Lys Thr Tyr Ser Tyr Gln Cys His Gly Leu Gly Gln Asp Leu
65                  70                  75                  80  
Glu Thr Ser Phe Gln Lys Leu Leu Pro Ser Gly Ser Gln Lys Tyr Leu
                85                  90                  95      
Asp Tyr Met Gln Gln Gly His Asn Leu Leu Ile Phe Val Lys Ser Trp
            100                 105                 110         
Ser Pro Asp Val Phe Ser Leu Pro Leu Arg Ile Cys Ser Leu Arg Ser
        115                 120                 125             
Asn Leu Tyr Arg Arg Asp Val Thr Ser Ala Ile Asn Leu Ser Ala Ser
    130                 135                 140                 
Ser Ala Leu Glu Leu Leu Arg Glu Lys Gly Phe Arg Ala Gln Arg Gly
145                 150                 155                 160 
Arg Pro Arg Val Lys Lys Leu His Pro Gln Gln Val Leu Asn Arg Cys
                165                 170                 175     
Ile Gln Glu Glu Glu Asp Met Arg Ile Leu Ala Ser Glu Phe Phe Lys
            180                 185                 190         
Lys Asp Lys Leu Met Tyr Lys Glu Lys Leu Asn Phe Thr Glu Ser Thr
        195                 200                 205             
His Val Glu Phe Lys Arg Phe Thr Thr Lys Lys Val Ile Pro Arg Ile
    210                 215                 220                 
Lys Glu Met Leu Pro His Tyr Val Ser Ala Phe Ala Asn Thr Gln Gly
225                 230                 235                 240 
Gly Tyr Val Leu Ile Gly Val Asp Asp Lys Ser Lys Glu Val Val Gly
                245                 250                 255     
Cys Lys Trp Glu Lys Val Asn Pro Asp Leu Leu Lys Lys Glu Ile Glu
            260                 265                 270         
Asn Cys Ile Glu Lys Leu Pro Thr Phe His Phe Cys Cys Glu Lys Pro
        275                 280                 285             
Lys Val Asn Phe Thr Thr Lys Ile Leu Asn Val Tyr Gln Lys Asp Val
    290                 295                 300                 
Leu Asp Gly Tyr Val Cys Val Ile Gln Val Glu Pro Phe Cys Cys Val
305                 310                 315                 320 
Val Phe Ala Glu Ala Pro Asp Ser Trp Ile Met Lys Asp Asn Ser Val
                325                 330                 335     
Thr Arg Leu Thr Ala Glu Gln Trp Val Val Met Met Leu Asp Thr Gln
            340                 345                 350         
Ser Ala Ser Ser Ala Arg Lys Ser Pro Gly Tyr Pro Ile Lys Val His
        355                 360                 365             
Lys Phe Lys Glu Ala Leu Gln Arg His Leu Phe Pro Val Thr Gln Glu
    370                 375                 380                 
Glu Val Gln Phe Lys Pro Glu Ser Leu Cys Lys Lys Leu Phe Ser Asp
385                 390                 395                 400 
His Lys Glu Leu Glu Gly Leu Met Lys Thr Leu Ile His Pro Cys Ser
                405                 410                 415     
Gln Gly Ile Val Ile Phe Ser Arg Ser Trp Ala Gly Asp Val Gly Phe
            420                 425                 430         
Arg Lys Glu Gln Asn Val Leu Cys Asp Ala Leu Leu Ile Ala Val Asn
        435                 440                 445             
Ser Pro Val Val Leu Tyr Thr Ile Leu Ile Asp Pro Asn Trp Pro Gly
    450                 455                 460                 
Gly Leu Glu Tyr Ala Arg Asn Thr Ala His Gln Leu Lys Gln Lys Leu
465                 470                 475                 480 
Gln Thr Val Gly Gly Tyr Thr Gly Lys Val Cys Ile Ile Pro Arg Leu
                485                 490                 495     
Ile His Leu Ser Ser Thr Gln Ser Arg Pro Gly Glu Ile Pro Leu Arg
            500                 505                 510         
Tyr Pro Arg Ser Tyr Arg Leu Ala Asp Glu Glu Glu Met Glu Asp Leu
        515                 520                 525             
Leu Gln Ala Leu Val Val Val Ser Leu Ser Ser Arg Ser Leu Leu Ser
    530                 535                 540                 
Asp Gln Met Gly Cys Glu Phe Phe Asn Leu Leu Ile Met Glu Gln Ser
545                 550                 555                 560 
Gln Leu Leu Ser Glu Ser Leu Gln Lys Thr Arg Glu Leu Phe Ile Tyr
                565                 570                 575     
Cys Phe Pro Gly Val Arg Lys Thr Ala Leu Ala Ile Lys Ile Met Glu
            580                 585                 590         
Lys Ile Lys Asp Leu Phe His Cys Lys Pro Lys Glu Ile Leu Tyr Val
        595                 600                 605             
Cys Glu Ser Asp Ser Leu Lys Asp Phe Val Thr Gln Gln Thr Thr Cys
    610                 615                 620                 
Gln Ala Val Thr Arg Lys Thr Phe Met Gln Gly Glu Phe Leu Lys Ile
625                 630                 635                 640 
Lys His Ile Val Met Asp Glu Thr Glu Asn Phe Cys Ser Lys Tyr Gly
                645                 650                 655     
Asn Trp Tyr Met Lys Ala Lys Asn Ile Thr His Pro Lys Ala Lys Gly
            660                 665                 670         
Thr Gly Ser Glu Asn Leu His His Gly Ile Leu Trp Leu Phe Leu Asp
        675                 680                 685             
Pro Phe Gln Ile His His Ala Asp Val Asn Gly Leu Pro Pro Pro Ser
    690                 695                 700                 
Ala Gln Phe Pro Arg Lys Thr Ile Thr Ser Gly Ile His Cys Ala Leu
705                 710                 715                 720 
Glu Ile Ala Lys Val Met Lys Glu Glu Met Lys Arg Ile Lys Glu Asn
                725                 730                 735     
Pro Pro Ser Asn Met Ser Pro Asp Thr Leu Ala Leu Phe Ser Glu Thr
            740                 745                 750         
Ala Tyr Glu Glu Ala Thr Cys Ala Gln Ala Leu Pro Gly Val Cys Glu
        755                 760                 765             
Thr Lys Thr Asn Leu Thr Thr Glu Gln Ile Ala Asn Tyr Val Ala Arg
    770                 775                 780                 
Lys Cys His Ser Leu Phe Gln Cys Gly Tyr Leu Pro Lys Asp Ile Ala
785                 790                 795                 800 
Ile Leu Cys Arg Arg Gly Glu Asp Arg Gly Arg Tyr Arg Leu Ala Leu
                805                 810                 815     
Leu Lys Ala Met Glu Leu Ile Glu Thr His Arg Pro Ser Glu Val Val
            820                 825                 830         
Phe Ser Pro Ala Thr Gly Val Trp Gly Ser His Ile Val Leu Asp Ser
        835                 840                 845             
Ile Gln Gln Phe Ser Gly Leu Glu Arg Thr Val Val Phe Gly Leu Ser
    850                 855                 860                 
Pro Glu Cys Asp Gln Ser Glu Glu Phe His Lys Leu Cys Phe Ala Ser
865                 870                 875                 880 
Arg Ala Ile Lys His Leu Tyr Leu Leu Tyr Glu Lys Arg Ala Ala Tyr
                885                 890                 895     


<210> 2638
<211> 357
<212> PRT
<213> Homo sapiens

<400> 2638
Met Glu Thr Arg Leu Pro Pro Arg Asn Ile Gln Asp Val Glu Ser Asp
 1               5                  10                  15      
Ser Ala Lys Gln Phe Leu Gln Ala Ala Glu Ala Ile Asp Asp Ile Pro
            20                  25                  30          
Phe Gly Ile Thr Ser Asn Ser Asp Val Phe Ser Lys Tyr Gln Leu Asp
        35                  40                  45              
Lys Asp Gly Val Val Leu Phe Lys Lys Phe Asp Glu Gly Arg Asn Asn
    50                  55                  60                  
Phe Glu Gly Glu Val Thr Lys Glu Asn Leu Leu Asp Phe Ile Lys His
65                  70                  75                  80  
Asn Gln Leu Pro Leu Val Ile Glu Phe Thr Glu Gln Thr Ala Pro Lys
                85                  90                  95      
Ile Phe Gly Gly Glu Ile Lys Thr His Ile Leu Leu Phe Leu Pro Lys
            100                 105                 110         
Ser Val Ser Asp Tyr Asp Gly Lys Leu Ser Asn Phe Lys Thr Ala Ala
        115                 120                 125             
Glu Ser Phe Lys Gly Lys Ile Leu Phe Ile Phe Ile Asp Ser Asp His
    130                 135                 140                 
Thr Asp Asn Gln Arg Ile Leu Glu Phe Phe Gly Leu Lys Lys Glu Glu
145                 150                 155                 160 
Cys Pro Ala Val Arg Leu Ile Thr Leu Glu Glu Glu Met Thr Lys Tyr
                165                 170                 175     
Lys Pro Glu Ser Glu Glu Leu Thr Ala Glu Arg Ile Thr Glu Phe Cys
            180                 185                 190         
His Arg Phe Leu Glu Gly Lys Ile Lys Pro His Leu Met Ser Gln Glu
        195                 200                 205             
Leu Pro Glu Asp Trp Asp Lys Gln Pro Val Lys Val Leu Val Gly Lys
    210                 215                 220                 
Asn Phe Glu Asp Val Ala Phe Asp Glu Lys Lys Asn Val Phe Val Glu
225                 230                 235                 240 
Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Gln Leu Ala Pro Ile Trp
                245                 250                 255     
Asp Lys Leu Gly Glu Thr Tyr Lys Asp His Glu Asn Ile Val Ile Ala
            260                 265                 270         
Lys Met Asp Ser Thr Ala Asn Glu Val Glu Ala Val Lys Val His Ser
        275                 280                 285             
Phe Pro Thr Leu Lys Phe Phe Pro Ala Ser Ala Asp Arg Thr Val Ile
    290                 295                 300                 
Asp Tyr Asn Gly Glu Arg Thr Leu Asp Gly Phe Lys Lys Phe Leu Glu
305                 310                 315                 320 
Ser Gly Gly Gln Asp Gly Ala Gly Asp Asp Asp Asp Leu Glu Asp Leu
                325                 330                 335     
Glu Glu Ala Glu Glu Pro Asp Met Glu Glu Asp Asp Asp Gln Lys Ala
            340                 345                 350         
Val Lys Asp Glu Leu
        355         


<210> 2639
<211> 930
<212> PRT
<213> Homo sapiens

<400> 2639
Met Tyr Glu Gly Ala Leu Arg Pro Pro Trp Phe Ser Arg Gln Leu Pro
 1               5                  10                  15      
Leu Ser Gly Gly Asn Asp Leu Trp Thr Asn Leu His Lys Trp Trp Phe
            20                  25                  30          
Ser Lys Ser Arg Ser His Ala Gly Gln His Val Thr Lys Leu Asn Gln
        35                  40                  45              
Asp Phe Gln Gly Pro Arg Arg Asp Val Pro Gly Val Gly Asn Ser Asn
    50                  55                  60                  
Gly Ser Gly Gln His Leu Leu Leu Thr Pro Cys Ala Pro Glu Phe Val
65                  70                  75                  80  
Thr Ile Val Ala Phe Ser Arg Glu Arg Gln Arg Ser Pro Arg Glu Thr
                85                  90                  95      
Thr His Ser Gly Pro Ala Ala Leu Leu Pro Lys Thr Val Pro Thr Ala
            100                 105                 110         
Val Gly Ser Leu Leu Pro Val Thr Met Glu Thr Gln Glu Gly Leu Tyr
        115                 120                 125             
Leu Pro Ile Met Thr Gln Ser His Thr Lys Cys Leu His Val Pro Gly
    130                 135                 140                 
Gln Ala Leu Ile Phe Thr Pro Tyr Ser Pro Pro Met Gly Thr Thr Gln
145                 150                 155                 160 
Lys Ile Pro Leu Lys Gly Arg Phe Ser Thr Val Tyr Phe Leu Cys Gly
                165                 170                 175     
Asn Phe Ser Gly Cys Ser Gly Leu Thr Ser Val Trp Asn Phe Arg His
            180                 185                 190         
His Ser Gln Gln His Leu Asp Tyr Lys Ala Ser Ser Gln Thr Val Thr
        195                 200                 205             
Asp Pro Ile Leu Pro Ile Arg Lys Leu Arg Leu Lys Asp Ala Gly Pro
    210                 215                 220                 
Glu Ser Phe Thr Val Ser Asn Thr Leu Met Leu Asn Gln Trp Arg Leu
225                 230                 235                 240 
Ile Ser Ala Asp Cys His Ala Trp Thr Leu Gly Ser Ala Pro Asp Thr
                245                 250                 255     
Ala Pro Pro Ser Ala Arg Gly Pro Pro Ile Gln Pro Ser Met Gln Pro
            260                 265                 270         
Thr Pro Ala Ile Ser Gln Ala Ser Leu Thr Trp Lys Ala Thr Leu Thr
        275                 280                 285             
Phe Ser Ala Gly Pro Asp Ser Glu Val Gly Ala Leu Asn Ala Ser Ile
    290                 295                 300                 
Cys Asn Phe Ser Leu Arg Leu Gly Asp Lys Lys Glu Pro Val Lys Met
305                 310                 315                 320 
Arg Arg Ala Ser Lys Tyr Val Lys Trp Pro Ile Val Ala Ala Ser Val
                325                 330                 335     
Cys Cys Cys Asn Arg Thr Ser Trp Met Asp Glu Met Ile Trp Leu Ile
            340                 345                 350         
Thr Thr Asp Leu Pro Gly Leu Leu Thr Lys Phe Leu Phe Asn Trp Phe
        355                 360                 365             
Leu Gln His Asp Leu Val Pro Glu Thr Ser Asp Ser Trp Lys Ala Glu
    370                 375                 380                 
Cys Gly Arg Ser Glu Ala Phe Pro Lys Thr Leu Ser Arg Glu Phe Gln
385                 390                 395                 400 
Lys Asp Ser Glu Lys Thr His Gly Leu Cys Ser Gln Gln Gln Ile Gln
                405                 410                 415     
Gly Leu Phe Cys Gly Val Cys Ser Leu Phe Pro Pro Thr His Leu Trp
            420                 425                 430         
Ile Leu Leu Pro Ala Ile Asp Phe Pro Ser Val Phe Thr Ser Phe Glu
        435                 440                 445             
Ala Gln His Val His Glu Thr Gly Leu Tyr Leu Glu Ile Pro Lys Thr
    450                 455                 460                 
Ile Ser Lys Arg Phe Leu Cys Ser Lys Glu Glu Lys Val Val Leu Gly
465                 470                 475                 480 
Trp Glu Asn Val Asp Phe Pro Arg Lys Thr Lys Ala Tyr Pro Val Ile
                485                 490                 495     
Cys Gln Lys Ile Glu His Lys Gln Leu Leu Gly Pro Thr Gly Gly Pro
            500                 505                 510         
Arg Gly Pro Leu Leu Trp Trp Ser Ile Leu Pro Val Val Pro Val Pro
        515                 520                 525             
Arg Gln Val Val Gly Val Lys Gln Val Met Ser Ala Val Met Tyr Arg
    530                 535                 540                 
Ser Pro Asp Leu Phe Asn Asn Lys Pro Ala Phe Tyr Pro Ser Tyr Phe
545                 550                 555                 560 
Glu Gly Met Cys Thr Arg Val Arg Ser Gly Arg Asn Pro Glu Gln Gly
                565                 570                 575     
Ser Asn Gln Trp His Arg Thr Gly Glu Gln Gly Ser Glu Gln Gly Ser
            580                 585                 590         
Asn Gln Trp His Arg Thr Gly Asp Gln Gly Leu Ala Leu Asn Glu Glu
        595                 600                 605             
His Gln Arg Arg Ala Ala Lys Gly Cys Val Gly Ser Thr Ala Arg Lys
    610                 615                 620                 
Met Trp Tyr Glu Val Asp Lys Gly Leu Ser Leu Arg Leu Asp Met Ile
625                 630                 635                 640 
Arg Asn Val Ile Leu Ser Tyr Gly Gln Gly Gly Lys Asn Ile Cys Asp
                645                 650                 655     
Gly Lys Glu Lys Leu Ala Ser Thr Ala Arg Glu Leu Ser Ile Gln Asn
            660                 665                 670         
Gly Pro Pro Leu His Asp Lys Ala Gln Asn Phe Gln Gln Lys Phe Gln
        675                 680                 685             
Thr His Ser Thr Leu Cys Thr Pro His Arg Gln Ala Arg Glu Thr Met
    690                 695                 700                 
Lys Thr His Lys Met Ile Ser His Lys Asn Tyr Lys Ser Leu Ile Gly
705                 710                 715                 720 
Asn Pro His Pro Leu Lys Gln Leu Leu Ser Gly Arg Pro Pro Val Arg
                725                 730                 735     
His Leu Lys Gly Ser Pro Asp Ala Pro Ser Gly Gly Phe Ala Ala Gly
            740                 745                 750         
Tyr Cys Arg Lys Gln Ser Leu Phe Phe Lys Ser Val Ala Gln Thr Ile
        755                 760                 765             
Ser Val Phe Gly Ser Lys Glu Asp Thr Gly Glu Arg Lys Leu Leu Gly
    770                 775                 780                 
Arg Lys Ser Asn Val Val Leu Ile Leu Gln Leu Ala Ser Ser Pro His
785                 790                 795                 800 
Pro Leu Ala Leu Glu Pro Ile Phe Leu Gln Glu Gly Phe Lys Ala Asn
                805                 810                 815     
Lys Glu Gly Ser Asn Gly Glu Ser Arg Gln Lys Lys Leu Glu Asn Leu
            820                 825                 830         
Ser Lys Glu Gly Pro Ser Ser Pro His Lys Ser Phe Ala Asp Gly Gly
        835                 840                 845             
Ser His Lys Ala Lys Thr Val Met Glu Arg Ala Arg Lys Gln His Ala
    850                 855                 860                 
Thr Leu Phe Ile Gly Ala Gly Gly Ser Ala Leu Thr Glu Ala Ala Pro
865                 870                 875                 880 
Pro Arg Arg His Ser Arg Glu Lys Trp Arg Arg Lys Glu Ser Gly Ser
                885                 890                 895     
Asp Met Asn Phe Asp Leu Phe Asp Lys Thr Ser Ser Thr Thr Cys Phe
            900                 905                 910         
Arg Glu Gln Leu Lys Ser Leu Arg Thr Pro Lys Pro Asp Leu Ser Ser
        915                 920                 925             
Ile Cys
    930 


<210> 2640
<211> 155
<212> PRT
<213> Homo sapiens

<400> 2640
Met Met Ala Arg Arg Asp Pro Lys Ser Trp Ala Lys Arg Leu Val Arg
 1               5                  10                  15      
Ala Gln Thr Leu Gln Lys Gln Arg Arg Ala Pro Val Gly Pro Arg Ala
            20                  25                  30          
Pro Pro Pro Asp Glu Glu Asp Pro Arg Leu Lys Cys Lys Asn Cys Gly
        35                  40                  45              
Ala Phe Gly His Thr Ala Arg Ser Thr Arg Cys Pro Met Lys Cys Trp
    50                  55                  60                  
Lys Ala Ala Leu Val Pro Ala Thr Leu Gly Lys Lys Glu Gly Lys Glu
65                  70                  75                  80  
Asn Leu Lys Pro Trp Lys Pro Arg Gly Glu Ala Asn Pro Gly Pro Leu
                85                  90                  95      
Asn Lys Asp Lys Gly Glu Lys Glu Glu Arg Pro Arg Ala Met Gln Leu
            100                 105                 110         
Leu Asp Lys Leu Gln Arg Cys Pro Arg Val Ser Lys Ser Pro Arg Thr
        115                 120                 125             
Lys Pro Asp Asp Lys Gln Gly Cys Ser Pro Gln Leu Gly Arg Gln Ile
    130                 135                 140                 
Ser Cys Pro His Arg Asp Ser Lys Met Leu Asn
145                 150                 155 


<210> 2641
<211> 714
<212> PRT
<213> Homo sapiens

<400> 2641
Met Val Ile Glu His Phe Val Pro Ser Val Leu Ile Phe Leu Leu Cys
 1               5                  10                  15      
Thr Cys Glu Ile Phe Gln Asp Ser Val Ala Phe Glu Asp Val Ala Ile
            20                  25                  30          
Asn Phe Thr Cys Glu Glu Trp Ala Leu Leu Gly Pro Ser Gln Lys Ser
        35                  40                  45              
Leu Tyr Arg Asp Val Met Gln Glu Thr Ile Arg Asn Leu Asp Cys Ile
    50                  55                  60                  
Gly Met Ile Trp Gln Asn His Asp Ile Glu Glu Asp Gln Tyr Lys Asp
65                  70                  75                  80  
Leu Arg Arg Asn Leu Arg Cys His Met Val Glu Arg Ala Cys Glu Ile
                85                  90                  95      
Lys Asp Asn Ser Gln Cys Gly Gly Pro Phe Thr Gln Thr Gln Asp Ser
            100                 105                 110         
Ile Val Asn Glu Lys Ile Pro Gly Val Asp Pro Trp Glu Ser Ser Glu
        115                 120                 125             
Cys Thr Asp Val Leu Met Gly Arg Ser Ser Leu Asn Cys Tyr Val Arg
    130                 135                 140                 
Val Asp Ser Glu His Lys Pro Cys Glu Tyr Gln Glu Tyr Gly Glu Lys
145                 150                 155                 160 
Pro Tyr Thr His Thr Gln Cys Gly Thr Ala Phe Ser Tyr Gln Pro Cys
                165                 170                 175     
Phe Gln Ile His Glu Arg Pro Gln His Gly Lys Lys Leu Tyr Asp Cys
            180                 185                 190         
Lys Glu Cys Ala Ser Phe Ser Ser Leu Glu Asn Leu Gln Arg His Met
        195                 200                 205             
Ala Ala His His Gly Asp Gly Pro Arg Ile Cys Lys Leu Cys Gly Asn
    210                 215                 220                 
Ala Phe Ile Trp Pro Ser Leu Phe His Met Leu Arg Arg Thr His Thr
225                 230                 235                 240 
Glu Glu Lys Pro Tyr Glu Tyr Glu Gln Cys Ser Thr Ala Phe Pro Ala
                245                 250                 255     
Tyr Ser Ser Thr Leu Arg His Glu Arg Thr His Ser Gly Glu Lys Pro
            260                 265                 270         
Tyr Gln Cys Lys Gln Cys Gly Lys Ala Phe Ser Cys Ser Cys Tyr Thr
        275                 280                 285             
Gln Leu Tyr Glu Arg Thr His Thr Gly Glu Gln Ser Tyr Glu Cys Lys
    290                 295                 300                 
Gln Cys Gly Lys Ala Phe Tyr His Leu Gly Ser Phe Gln Arg His Met
305                 310                 315                 320 
Ile Val His Thr Gly Asp Gly Pro His Lys Cys Lys Ile Cys Gly Lys
                325                 330                 335     
Gly Phe Leu Ser Pro Ser Ser Val Arg Arg His Lys Arg Thr His Thr
            340                 345                 350         
Gly Glu Lys Pro Tyr Glu Cys Lys Tyr Cys Gly Lys Ala Phe Ser Asp
        355                 360                 365             
Cys Thr Gly Phe Arg Arg His Met Ile Thr His Thr Gly Asp Gly Pro
    370                 375                 380                 
His Lys Cys Lys Val Cys Gly Lys Ala Phe Asp Ser Pro Ser Leu Cys
385                 390                 395                 400 
Arg Arg His Glu Thr Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Glu
                405                 410                 415     
Cys Gly Lys Ala Phe Ser Asp Phe Tyr Tyr Phe Arg Asn His Glu Thr
            420                 425                 430         
Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Lys Gln Cys Gly Lys Ala
        435                 440                 445             
Phe Ile Cys Cys Thr Tyr Leu Gln Ile His Glu Arg Ile His Thr Gly
    450                 455                 460                 
Glu Arg Pro Tyr Lys Cys Lys Gln Cys Gly Lys Ala Phe Arg Ser Ser
465                 470                 475                 480 
Asn Tyr Ile Arg Val His Glu Lys Thr His Thr Gly Glu Lys Pro Tyr
                485                 490                 495     
Glu Cys Lys Gln Cys Gly Lys Ala Leu Ser His Leu Lys Ser Phe Gln
            500                 505                 510         
Arg His Met Ile Met His Thr Gly Asp Gly Pro His Lys Cys Lys Ile
        515                 520                 525             
Cys Gly Lys Ser Phe Asp Ser Pro Ser Ser Phe Arg Arg His Glu Arg
    530                 535                 540                 
Ile His Thr Gly Glu Arg Pro Tyr Lys Cys Lys Leu Cys Gly Lys Gly
545                 550                 555                 560 
Phe Arg Ser Ser Ser Tyr Ile Gln Leu His Glu Arg Thr His Thr Gly
                565                 570                 575     
Glu Lys Pro Tyr Gly Cys Gln Gln Cys Gly Lys Ala Leu Ser Asp Leu
            580                 585                 590         
Ser Ser Phe Arg Arg His Met Ile Thr His Thr Gly Asn Gly Pro His
        595                 600                 605             
Lys Cys Lys Ile Cys Gly Lys Gly Phe Asp Tyr Pro Ser Ser Val Gln
    610                 615                 620                 
Arg His Glu Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu
625                 630                 635                 640 
Cys Gly Lys Ala Phe Ser His Ser Ser Tyr Leu Arg Ile His Glu Arg
                645                 650                 655     
Val His Thr Gly Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly Lys Pro
            660                 665                 670         
Phe His Cys Pro Ser Ala Phe His Lys His Glu Arg Thr His Ser Met
        675                 680                 685             
Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly Glu Ala Phe His Cys Ile
    690                 695                 700                 
Ser Ser Phe His Lys His Glu Met Thr His
705                 710                 


<210> 2642
<211> 116
<212> PRT
<213> Homo sapiens

<400> 2642
Met Ala Cys Thr Ala Gln Arg Thr Gln Trp Ala Leu Thr Lys Arg Ser
 1               5                  10                  15      
Leu Arg Ala Thr Arg Glu Ser Val Ser Arg Gln Gln Gly Val Tyr Gly
            20                  25                  30          
Leu Val Gly Arg Lys Arg Thr Arg His His Arg Gly Val Leu Gly Leu
        35                  40                  45              
Leu Gly Ile Pro Ser Ala Arg Pro Glu Arg Pro Gly Thr Gly Ser Glu
    50                  55                  60                  
Ala Gly Pro Thr Arg Leu Pro Gly Ala Ala Val Ala Arg Arg Arg Pro
65                  70                  75                  80  
Ala Arg Leu Pro Ala Gln Asp Gly Asn Ile Asn Asn Asn Ile Lys Leu
                85                  90                  95      
Gly Ser Phe Ile Pro Leu Leu Leu Ser Thr Leu His Ala Gly His Ser
            100                 105                 110         
Pro Arg Arg Lys
        115     


<210> 2643
<211> 458
<212> PRT
<213> Homo sapiens

<400> 2643
Met Ala Met Ala Thr Thr Gln Ser Ser Met Asp Ala Gly Val Ser Arg
 1               5                  10                  15      
Gly Pro Ile Pro Thr Ile Gln Ser Ser Met Asn Thr Gly Val Ser Pro
            20                  25                  30          
Gly Pro Val Pro Thr Ile Gln Ser Ser Met Asn Thr Ala Val Ser Pro
        35                  40                  45              
Gly Pro Val Pro Thr Thr Gln Ser Ser Met Asp Thr Gly Val Ser Leu
    50                  55                  60                  
Gly Pro Val Pro Asn Thr Gln Ser Ser Met Asp Thr Gly Val Ser Pro
65                  70                  75                  80  
Gly Pro Val Pro Thr Thr Gln Ser Ser Met Asp Thr Gly Val Ser Pro
                85                  90                  95      
Gly Pro Val Pro Thr Thr Gln Ser Ser Met Asp Thr Gly Val Ser Ala
            100                 105                 110         
Gly Pro Ile Pro Thr Thr Gln Ser Phe Cys Gly Asp His Asp Val Thr
        115                 120                 125             
Arg Ala His Pro His His Thr Glu Leu His Gly His Arg Val Glu Pro
    130                 135                 140                 
Ala Asp Pro Asp Pro Trp Lys Pro Glu Pro Ser Gly Phe Ala Val Cys
145                 150                 155                 160 
Glu Asp Glu Arg Pro Ser Gln Ala Ala Phe Arg Phe Arg Asp Pro Ala
                165                 170                 175     
Arg Val Gly Gln Thr Gly Leu Gln Gly Leu Val Leu Glu Glu Pro Gly
            180                 185                 190         
Glu Gln Glu Glu Ser Glu Ala Gly Gly Ala Pro Gln Pro Arg Gly Asn
        195                 200                 205             
Arg Ala Ser Val Asn Ser Thr Ser Pro Ala Leu Ser Gln Gly Met Trp
    210                 215                 220                 
Leu Gln Pro Pro Arg Gly Ser Pro Gly Asn Val Glu Ser Leu Thr Thr
225                 230                 235                 240 
Gly Arg Gln Thr Leu Thr Gly Ser Phe Ala Asn Ala Thr Gln Ile Thr
                245                 250                 255     
Ala Asn Ala Asn Leu Ala Met Val Gln Thr Pro Arg Ser Asn Phe Leu
            260                 265                 270         
Ser Val Pro Ala His Ser Pro Pro Lys Val Thr Asp Lys Ile Glu Phe
        275                 280                 285             
Asp Thr Val Arg Leu Cys Ser Pro Val Asn Ala Pro Gln Ile Arg Ala
    290                 295                 300                 
Cys Lys Lys Pro Pro Ser Arg Ala Trp Ala Lys Gly Asp Ser Arg Ser
305                 310                 315                 320 
Ser Leu Pro Gly Ser Pro Asn Ser Pro Ala Ala Pro Gly His Leu Gly
                325                 330                 335     
Thr Gln Pro Leu Val Arg Arg Asp Gly Glu Ala Thr Asn Arg Ala Ala
            340                 345                 350         
Asp Asn Asp Gln Glu Gly Gly Pro Arg Gly Thr Arg Lys Thr Pro Leu
        355                 360                 365             
Leu Pro Arg Gln Arg Pro Pro Ser Gln Leu Pro Glu Gly Thr Gly Leu
    370                 375                 380                 
Val Pro Gly Ala Val Pro Ala Arg Ser Thr Pro Gly Ser Cys Glu Pro
385                 390                 395                 400 
Ala Gly Thr Cys Arg Lys Tyr Lys Gln Leu Gln Lys Ser Lys Ser Pro
                405                 410                 415     
Val Met Val His Arg Gln Gly Thr His Arg Ser Cys Leu Ala Leu Val
            420                 425                 430         
Val Ser Pro Pro Arg Thr Leu Thr Lys Thr Thr Tyr Ile Leu Leu Arg
        435                 440                 445             
Thr Cys Gly Asp Lys Tyr Thr Gly Pro Met
    450                 455             


<210> 2644
<211> 686
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 549, 550, 551, 552, 553, 554, 555
<223> Xaa = Any Amino Acid

<400> 2644
Met Thr Asp Ala Leu Leu Pro Ala Ala Pro Gln Pro Leu Glu Lys Glu
 1               5                  10                  15      
Asn Asp Gly Tyr Phe Arg Lys Gly Cys Asn Pro Leu Ala Gln Thr Gly
            20                  25                  30          
Arg Ser Lys Leu Gln Asn Gln Arg Ala Ala Leu Asn Gln Gln Ile Leu
        35                  40                  45              
Lys Ala Val Arg Met Arg Thr Gly Ala Glu Asn Leu Leu Lys Val Ala
    50                  55                  60                  
Thr Asn Ser Lys Val Arg Glu Gln Val Arg Leu Glu Leu Ser Phe Val
65                  70                  75                  80  
Asn Ser Asp Leu Gln Met Leu Lys Glu Glu Leu Glu Gly Leu Asn Ile
                85                  90                  95      
Ser Val Gly Val Tyr Gln Asn Thr Glu Glu Ala Phe Thr Ile Pro Leu
            100                 105                 110         
Ile Pro Leu Gly Leu Lys Glu Thr Lys Asp Val Asp Phe Ala Val Val
        115                 120                 125             
Leu Lys Asp Phe Ile Leu Glu His Tyr Ser Glu Asp Gly Tyr Leu Tyr
    130                 135                 140                 
Glu Asp Glu Ile Ala Asp Leu Met Asp Leu Arg Gln Ala Cys Arg Thr
145                 150                 155                 160 
Pro Ser Arg Asp Glu Ala Gly Val Glu Leu Leu Met Thr Tyr Phe Ile
                165                 170                 175     
Gln Leu Gly Phe Val Glu Ser Arg Phe Phe Pro Pro Thr Arg Gln Met
            180                 185                 190         
Gly Leu Leu Phe Thr Trp Tyr Asp Ser Leu Thr Gly Val Pro Val Ser
        195                 200                 205             
Gln Gln Asn Leu Leu Leu Glu Lys Ala Ser Val Leu Phe Asn Thr Gly
    210                 215                 220                 
Ala Leu Tyr Thr Gln Ile Gly Thr Arg Cys Asp Arg Gln Thr Gln Ala
225                 230                 235                 240 
Gly Leu Glu Ser Ala Ile Asp Ala Phe Gln Arg Ala Ala Gly Val Leu
                245                 250                 255     
Asn Tyr Leu Lys Asp Thr Phe Thr His Thr Pro Ser Tyr Asp Met Ser
            260                 265                 270         
Pro Ala Met Leu Ser Val Leu Val Lys Met Met Leu Ala Gln Ala Gln
        275                 280                 285             
Glu Ser Val Phe Glu Lys Ile Ser Leu Pro Gly Ile Arg Asn Glu Phe
    290                 295                 300                 
Phe Met Leu Val Lys Val Ala Gln Glu Ala Ala Lys Val Gly Glu Val
305                 310                 315                 320 
Tyr Gln Gln Leu His Ala Ala Met Ser Gln Ala Pro Val Lys Glu Asn
                325                 330                 335     
Ile Pro Tyr Ser Trp Ala Ser Leu Ala Cys Val Lys Ala His His Tyr
            340                 345                 350         
Ala Ala Leu Ala His Tyr Phe Thr Ala Ile Leu Leu Ile Asp His Gln
        355                 360                 365             
Val Lys Pro Gly Thr Asp Leu Asp His Gln Glu Lys Cys Leu Ser Gln
    370                 375                 380                 
Leu Tyr Asp His Met Pro Glu Gly Leu Thr Pro Leu Ala Thr Leu Lys
385                 390                 395                 400 
Asn Asp Gln Gln Arg Arg Gln Leu Gly Lys Ser His Leu Arg Arg Ala
                405                 410                 415     
Met Ala His His Glu Glu Ser Val Arg Glu Ala Ser Leu Cys Lys Lys
            420                 425                 430         
Leu Arg Ser Ile Glu Val Leu Gln Lys Val Leu Cys Ala Ala Gln Glu
        435                 440                 445             
Arg Ser Arg Leu Thr Tyr Ala Gln His Gln Glu Glu Asp Asp Leu Leu
    450                 455                 460                 
Asn Leu Ile Asp Ala Pro Ser Val Val Ala Lys Thr Glu Gln Glu Val
465                 470                 475                 480 
Asp Ile Ile Leu Pro Gln Phe Ser Lys Leu Thr Val Thr Asp Phe Phe
                485                 490                 495     
Gln Lys Leu Gly Pro Leu Ser Val Phe Ser Ala Asn Lys Arg Trp Thr
            500                 505                 510         
Pro Pro Arg Ser Ile Arg Phe Thr Ala Glu Glu Gly Asp Leu Gly Phe
        515                 520                 525             
Thr Leu Arg Gly Asn Ala Pro Val Gln Val His Phe Leu Asp Pro Tyr
    530                 535                 540                 
Cys Ser Ala Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asp Tyr Ile Val Ser
545                 550                 555                 560 
Ile Gln Leu Val Asp Cys Lys Trp Leu Thr Leu Ser Glu Val Met Lys
                565                 570                 575     
Leu Leu Lys Ser Phe Gly Glu Asp Glu Ile Glu Met Lys Val Val Ser
            580                 585                 590         
Leu Leu Asp Ser Thr Ser Ser Met His Asn Lys Ser Ala Thr Tyr Ser
        595                 600                 605             
Val Gly Met Gln Lys Thr Tyr Ser Met Ile Cys Leu Ala Ile Asp Asp
    610                 615                 620                 
Asp Asp Lys Thr Asp Lys Thr Lys Lys Ile Ser Lys Lys Leu Ser Phe
625                 630                 635                 640 
Leu Ser Trp Gly Thr Asn Lys Asn Arg Gln Lys Ser Ala Ser Thr Leu
                645                 650                 655     
Cys Leu Pro Ser Val Gly Ala Ala Arg Pro Gln Val Lys Lys Lys Leu
            660                 665                 670         
Pro Ser Pro Phe Ser Leu Leu Asn Ser Asp Ser Ser Trp Tyr
        675                 680                 685     


<210> 2645
<211> 161
<212> PRT
<213> Homo sapiens

<400> 2645
Met Ala Glu Pro Thr Gly Leu Leu Glu Met Ser Glu Leu Pro Gly Asp
 1               5                  10                  15      
Ser Ser Val Pro Gln Val Gly Thr Ala Ser Gly Val Ser Asp Val Leu
            20                  25                  30          
Arg Gly Ala Val Gly Gly Gly Val Arg Val Gln Glu Ala Arg Glu Gly
        35                  40                  45              
Pro Val Ala Glu Ala Ala Arg Ser Met Ala Arg Met Pro Gly Pro Val
    50                  55                  60                  
Pro Gly Pro Ile Pro Ser Ser Val Pro Gly Leu Ala Ser Ala Pro Asp
65                  70                  75                  80  
Pro His Gln Gln Leu Ala Phe Leu Glu Ile Asn Arg Gln Leu Leu Phe
                85                  90                  95      
Arg Glu Tyr Leu Asp Gly Ser Ser Met Ile Pro Val Arg Leu Leu Arg
            100                 105                 110         
Asp Phe Glu Glu Arg Arg Arg Leu Phe Val Glu Gly Cys Lys Ala Arg
        115                 120                 125             
Glu Ala Ala Phe Asp Ala Asp Pro Pro Gln Met Asp Phe Ala Ala Val
    130                 135                 140                 
Ala Phe Thr Val Ala Leu Thr Ala Ser Glu Ala Leu Ser Pro Leu Ala
145                 150                 155                 160 
Asp
    


<210> 2646
<211> 218
<212> PRT
<213> Homo sapiens

<400> 2646
Met Gly Thr Arg Asp Asp Glu Tyr Asp Tyr Leu Phe Lys Val Val Leu
 1               5                  10                  15      
Ile Gly Asp Ser Gly Val Gly Lys Ser Asn Leu Leu Ser Arg Phe Thr
            20                  25                  30          
Arg Asn Glu Phe Asn Leu Glu Ser Lys Ser Thr Ile Gly Val Glu Phe
        35                  40                  45              
Ala Thr Arg Ser Ile Gln Val Asp Gly Lys Thr Ile Lys Ala Gln Ile
    50                  55                  60                  
Trp Asp Thr Ala Gly Gln Glu Arg Tyr Arg Ala Ile Thr Ser Ala Tyr
65                  70                  75                  80  
Tyr Arg Gly Ala Val Gly Ala Leu Leu Val Tyr Asp Ile Ala Lys His
                85                  90                  95      
Leu Thr Tyr Glu Asn Val Glu Arg Trp Leu Lys Glu Leu Arg Asp His
            100                 105                 110         
Ala Asp Ser Asn Ile Val Ile Met Leu Val Gly Asn Lys Ser Asp Leu
        115                 120                 125             
Arg His Leu Arg Ala Val Pro Thr Asp Glu Ala Arg Ala Phe Ala Glu
    130                 135                 140                 
Lys Asn Asn Leu Ser Phe Ile Glu Thr Ser Ala Leu Asp Ser Thr Asn
145                 150                 155                 160 
Val Glu Glu Ala Phe Lys Asn Ile Leu Thr Glu Ile Tyr Arg Ile Val
                165                 170                 175     
Ser Gln Lys Gln Ile Ala Asp Arg Ala Ala His Asp Glu Ser Pro Gly
            180                 185                 190         
Asn Asn Val Val Asp Ile Ser Val Pro Pro Thr Thr Asp Gly Gln Lys
        195                 200                 205             
Pro Asn Lys Leu Gln Cys Cys Gln Asn Leu
    210                 215             


<210> 2647
<211> 658
<212> PRT
<213> Homo sapiens

<400> 2647
Met Trp Thr Pro Val Arg Arg Gly Ala Ala Trp Leu Gly Thr Leu Leu
 1               5                  10                  15      
Gly Pro Gly Glu Gly Pro Pro Glu Pro Arg Gly Gly Ala Ala His Ala
            20                  25                  30          
His Lys Pro Pro Ala Gly Ser Arg Lys Ser Thr Asp Gln Ala Val Arg
        35                  40                  45              
Phe Gly Pro Ser Gln Gly Met Cys Ser Glu Ala Arg Leu Ala Arg Arg
    50                  55                  60                  
Ala Val Glu Glu Leu Leu Arg Cys Gly Ala Asp Pro Asn Leu Val Leu
65                  70                  75                  80  
Glu Asp Gly Ala Ala Ala Val His Leu Ala Ala Gly Ala Arg His Pro
                85                  90                  95      
Arg Gly Leu Arg Cys Leu Gly Ala Leu Leu Arg Gln Gly Gly Asp Pro
            100                 105                 110         
Asn Ala Arg Ser Val Glu Ala Leu Thr Pro Leu His Val Ala Ala Ala
        115                 120                 125             
Trp Gly Cys Arg Arg Gly Leu Glu Leu Leu Leu Ser Gln Gly Ala Asp
    130                 135                 140                 
Pro Ala Leu Arg Asp Gln Asp Gly Leu Arg Pro Leu Asp Leu Ala Leu
145                 150                 155                 160 
Gln Gln Gly His Leu Glu Cys Ala Arg Val Leu Gln Asp Leu Asp Thr
                165                 170                 175     
Arg Thr Arg Thr Arg Thr Arg Ile Gly Ala Glu Thr Gln Glu Pro Glu
            180                 185                 190         
Pro Ala Pro Gly Thr Pro Gly Leu Ser Gly Pro Thr Asp Glu Thr Leu
        195                 200                 205             
Asp Ser Ile Ala Leu Gln Lys Gln Pro Cys Arg Gly Asp Asn Arg Asp
    210                 215                 220                 
Ile Gly Leu Glu Ala Asp Pro Gly Pro Pro Ser Leu Pro Val Pro Leu
225                 230                 235                 240 
Glu Thr Val Asp Lys His Gly Ser Ser Ala Ser Pro Pro Gly His Trp
                245                 250                 255     
Asp Tyr Ser Ser Asp Ala Ser Phe Val Thr Ala Val Glu Val Ser Gly
            260                 265                 270         
Ala Glu Asp Pro Ala Ser Asp Thr Pro Pro Trp Ala Gly Ser Leu Pro
        275                 280                 285             
Pro Thr Arg Gln Gly Leu Leu His Val Val His Ala Asn Gln Arg Val
    290                 295                 300                 
Pro Arg Ser Gln Gly Thr Glu Ala Glu Leu Asn Ala Arg Leu Gln Ala
305                 310                 315                 320 
Leu Thr Leu Thr Pro Pro Asn Ala Ala Gly Phe Gln Ser Ser Pro Ser
                325                 330                 335     
Ser Met Pro Leu Leu Asp Arg Ser Pro Ala His Ser Pro Pro Arg Thr
            340                 345                 350         
Pro Thr Pro Gly Ala Ser Asp Cys His Cys Leu Trp Glu His Gln Thr
        355                 360                 365             
Ser Ile Asp Ser Asp Met Ala Thr Leu Trp Leu Thr Glu Asp Glu Ala
    370                 375                 380                 
Ser Ser Thr Gly Gly Arg Glu Pro Val Gly Pro Cys Arg His Leu Pro
385                 390                 395                 400 
Val Ser Thr Val Ser Asp Leu Glu Leu Leu Lys Gly Leu Arg Ala Leu
                405                 410                 415     
Gly Glu Asn Pro His Pro Ile Thr Pro Phe Thr Arg Gln Leu Tyr His
            420                 425                 430         
Gln Gln Leu Glu Glu Ala Gln Ile Ala Pro Gly Pro Glu Phe Ser Gly
        435                 440                 445             
His Ser Leu Glu Leu Ala Ala Ala Leu Arg Thr Gly Cys Ile Pro Asp
    450                 455                 460                 
Val Gln Ala Asp Glu Asp Ala Leu Ala Gln Gln Phe Glu Gln Pro Asp
465                 470                 475                 480 
Pro Ala Arg Arg Trp Arg Glu Gly Val Val Lys Ser Ser Phe Thr Tyr
                485                 490                 495     
Leu Leu Leu Asp Pro Arg Glu Thr Gln Asp Leu Pro Ala Arg Ala Phe
            500                 505                 510         
Ser Leu Thr Pro Ala Glu Arg Leu Gln Thr Phe Ile Arg Ala Ile Phe
        515                 520                 525             
Tyr Val Gly Lys Gly Thr Arg Ala Arg Pro Tyr Val His Leu Trp Glu
    530                 535                 540                 
Ala Leu Gly His His Gly Arg Ser Arg Lys Gln Pro His Gln Ala Cys
545                 550                 555                 560 
Pro Lys Val Arg Gln Ile Leu Asp Ile Trp Ala Ser Gly Cys Gly Val
                565                 570                 575     
Val Ser Leu His Cys Phe Gln His Val Val Ala Val Glu Ala Tyr Thr
            580                 585                 590         
Arg Glu Ala Cys Ile Val Glu Ala Leu Gly Ile Gln Thr Leu Thr Asn
        595                 600                 605             
Gln Lys Gln Gly His Cys Tyr Gly Val Val Ala Gly Trp Pro Pro Ala
    610                 615                 620                 
Arg Arg Arg Arg Leu Gly Val His Leu Leu His Arg Ala Leu Leu Val
625                 630                 635                 640 
Phe Leu Ala Glu Gly Glu Arg Gln Leu His Pro Gln Asp Ile Gln Ala
                645                 650                 655     
Arg Gly
        


<210> 2648
<211> 430
<212> PRT
<213> Homo sapiens

<400> 2648
Met Gly Asp Leu Asp Val Pro Leu Glu Gln Glu Met Ala Lys Glu Asp
 1               5                  10                  15      
Pro Val Cys Ala Pro Glu Ser Met Gly Ser Glu Asp Met Leu Phe Met
            20                  25                  30          
Leu Tyr Thr Ser Gly Ser Thr Gly Met Pro Lys Gly Ile Val His Thr
        35                  40                  45              
Gln Ala Gly Tyr Leu Leu Tyr Ala Ala Leu Thr His Lys Leu Val Phe
    50                  55                  60                  
Asp His Gln Pro Gly Asp Ile Phe Gly Cys Val Ala Asp Ile Gly Trp
65                  70                  75                  80  
Ile Thr Gly His Ser Tyr Val Val Tyr Gly Pro Leu Cys Asn Gly Ala
                85                  90                  95      
Thr Ser Val Leu Phe Glu Ser Thr Pro Val Tyr Pro Asn Ala Gly Arg
            100                 105                 110         
Tyr Trp Glu Thr Val Glu Arg Leu Lys Ile Asn Gln Phe Tyr Gly Ala
        115                 120                 125             
Pro Thr Ala Val Arg Leu Leu Leu Lys Tyr Gly Asp Ala Trp Val Lys
    130                 135                 140                 
Lys Tyr Asp Arg Ser Ser Leu Arg Thr Leu Gly Ser Val Gly Glu Pro
145                 150                 155                 160 
Ile Asn Cys Glu Ala Trp Glu Trp Leu His Arg Val Val Gly Asp Ser
                165                 170                 175     
Arg Cys Thr Leu Val Asp Thr Trp Trp Gln Thr Glu Thr Gly Gly Ile
            180                 185                 190         
Cys Ile Ala Pro Arg Pro Ser Glu Glu Gly Ala Glu Ile Leu Pro Ala
        195                 200                 205             
Met Ala Met Arg Pro Phe Phe Gly Ile Val Pro Val Leu Met Asp Glu
    210                 215                 220                 
Lys Gly Ser Val Val Glu Gly Ser Asn Val Ser Gly Ala Leu Cys Ile
225                 230                 235                 240 
Ser Gln Ala Trp Pro Gly Met Ala Arg Thr Ile Tyr Gly Asp His Gln
                245                 250                 255     
Arg Phe Val Asp Ala Tyr Phe Lys Ala Tyr Pro Gly Tyr Tyr Phe Thr
            260                 265                 270         
Gly Asp Gly Ala Tyr Arg Thr Glu Gly Gly Tyr Tyr Gln Ile Thr Gly
        275                 280                 285             
Arg Met Asp Asp Val Ile Asn Ile Ser Gly His Arg Leu Gly Thr Ala
    290                 295                 300                 
Glu Ile Glu Asp Ala Ile Ala Asp His Pro Ala Val Pro Glu Ser Ala
305                 310                 315                 320 
Val Ile Gly Tyr Pro His Asp Ile Lys Gly Glu Ala Ala Phe Ala Phe
                325                 330                 335     
Ile Val Val Lys Asp Ser Ala Gly Asp Ser Asp Val Val Val Gln Glu
            340                 345                 350         
Leu Lys Ser Met Val Ala Thr Lys Ile Ala Lys Tyr Ala Val Pro Asp
        355                 360                 365             
Glu Ile Leu Val Val Lys Arg Leu Pro Lys Thr Arg Ser Gly Lys Val
    370                 375                 380                 
Met Arg Arg Leu Leu Arg Lys Ile Ile Thr Ser Glu Ala Gln Glu Leu
385                 390                 395                 400 
Gly Asp Thr Thr Thr Leu Glu Asp Pro Ser Ile Ile Ala Glu Ile Leu
                405                 410                 415     
Ser Val Tyr Gln Lys Cys Lys Asp Lys Gln Ala Ala Ala Lys
            420                 425                 430 


<210> 2649
<211> 361
<212> PRT
<213> Homo sapiens

<400> 2649
Met Gly His Glu Gly Asp Gly Gly Met Gly Arg Gly Met Asp Pro Asp
 1               5                  10                  15      
Pro Asp Lys Thr Ala Asn Gly Asn Gly Thr Glu Asn Glu Thr Ala Gln
            20                  25                  30          
Ser Trp Thr Asp Leu Leu Ile Lys Ala Thr Arg Leu His Ser Pro Ala
        35                  40                  45              
Ala Thr Ala Leu Pro Ser Leu Gly Ala Gln Pro Leu Trp Gly Glu Gly
    50                  55                  60                  
Gly Leu Arg Met Pro Gly Glu Gly Ser Asp Pro Ala Phe Ser Pro Leu
65                  70                  75                  80  
Ala Gln Ser Leu Val Gly Arg Val Glu Gly Glu Cys Gly Gly Trp Gln
                85                  90                  95      
Leu Ser Gly Gly Ala Trp Gly Leu Gln Arg Gly Asp Gly Ala Glu Met
            100                 105                 110         
Ile Ser Glu Leu Phe Gly Glu Asp Arg Ser Ser Thr Ser Pro Cys Gly
        115                 120                 125             
Thr Ser Leu Ile Phe Leu Pro Ala Leu Ser Pro Pro Trp Ala Gly Ser
    130                 135                 140                 
Pro Ala Ala Asn Thr Gly Gly Ser Ser Leu Thr Met Gly Ser Trp Trp
145                 150                 155                 160 
Asp Pro Ala Ser Leu Arg Pro Arg Gln Gly Phe Cys Leu Glu Glu Gly
                165                 170                 175     
Ser Ser Thr Gly Gln Ser Ile Arg Gly Ser Glu Trp Thr Arg His Thr
            180                 185                 190         
Ala Gln Lys Val Leu Pro Ala Leu Arg Gly Asp Phe Leu Glu Ser Glu
        195                 200                 205             
Trp Arg Glu Pro Gln Lys Gln Glu Leu Gly Gln Glu Gln Trp Gly Asp
    210                 215                 220                 
Leu Cys Cys Arg Pro Ile Ala His Val Arg Glu Met Pro Val Glu Asn
225                 230                 235                 240 
Leu Lys Met Ser Ala Pro Gly Ser His Leu Arg Pro Met Pro Ser Pro
                245                 250                 255     
Glu Val Gln Trp Ala Thr Glu Thr Leu Gly Glu Leu Ala Val Arg Ala
            260                 265                 270         
Ala Ser Ala Lys Gly Phe Arg Ser Ala Tyr Cys Cys Gly Leu Gln Pro
        275                 280                 285             
Ala Ala Leu Pro Ser Trp Val Arg Arg Gln Leu Met Pro Thr Gly Ala
    290                 295                 300                 
Leu Gly Cys Gln Arg Trp Gly Gly Ser Leu Asp Pro Val Arg Glu Leu
305                 310                 315                 320 
Leu Ala Lys Gly Leu Val Ser His Glu Ala Asn Gly Asp Gln Ala Gly
                325                 330                 335     
Trp Val Pro Gly Ala Pro Glu Gly Arg Arg Lys Gly Ala Gly Ile Cys
            340                 345                 350         
Gly Gly Pro Leu Leu Thr Lys Thr Ala
        355                 360     


<210> 2650
<211> 1117
<212> PRT
<213> Homo sapiens

<400> 2650
Met Lys Lys Ala Ser Arg Ser Val Gly Ser Val Pro Lys Val Ser Ala
 1               5                  10                  15      
Ile Ser Lys Thr Gln Thr Ala Glu Lys Ile Lys Pro Glu Asn Ser Ser
            20                  25                  30          
Ser Ala Ser Thr Gly Gly Lys Leu Val Lys Pro Gly Thr Ala Ala Ser
        35                  40                  45              
Leu Ser Lys Thr Lys Ser Ser Asp Asp Leu Leu Ala Gly Met Ala Gly
    50                  55                  60                  
Gly Val Thr Val Thr Asn Gly Val Lys Gly Lys Lys Ser Thr Cys Pro
65                  70                  75                  80  
Ser Ala Ala Pro Ser Ala Ser Ala Pro Ala Met Thr Thr Val Glu Asn
                85                  90                  95      
Lys Ser Lys Ile Ser Thr Gly Thr Ala Ser Ser Thr Lys Arg Ser Thr
            100                 105                 110         
Ser Thr Gly Asn Lys Glu Ser Ser Ser Thr Arg Glu Arg Leu Arg Glu
        115                 120                 125             
Arg Thr Arg Leu Asn Gln Ser Lys Lys Leu Pro Ser Ala Gly Gln Gly
    130                 135                 140                 
Ala Asn Asp Met Ala Leu Ala Lys Arg Ser Arg Ser Arg Thr Ala Thr
145                 150                 155                 160 
Glu Cys Asp Val Arg Met Ser Lys Ser Lys Ser Asp Asn Gln Ile Ser
                165                 170                 175     
Asp Arg Ala Ala Leu Glu Ala Lys Val Lys Asp Leu Leu Thr Leu Ala
            180                 185                 190         
Lys Thr Lys Asp Val Glu Ile Leu His Leu Arg Asn Glu Leu Arg Asp
        195                 200                 205             
Met Arg Ala Gln Leu Gly Ile Asn Glu Asp His Ser Glu Gly Asp Glu
    210                 215                 220                 
Lys Ser Glu Lys Glu Thr Ile Met Ala His Gln Pro Thr Asp Val Glu
225                 230                 235                 240 
Ser Thr Leu Leu Gln Leu Gln Glu Gln Asn Thr Ala Ile Arg Glu Glu
                245                 250                 255     
Leu Asn Gln Leu Lys Asn Glu Asn Arg Met Leu Lys Asp Arg Leu Asn
            260                 265                 270         
Ala Leu Gly Phe Ser Leu Glu Gln Arg Leu Asp Asn Ser Glu Lys Leu
        275                 280                 285             
Phe Gly Tyr Gln Ser Leu Ser Pro Glu Ile Thr Pro Asp Asn Gln Ser
    290                 295                 300                 
Asp Gly Gly Gly Thr Leu Thr Ser Ser Val Glu Gly Ser Ala Pro Gly
305                 310                 315                 320 
Ser Val Glu Asp Leu Leu Ser Gln Asp Glu Asn Thr Leu Met Asp His
                325                 330                 335     
Gln His Ser Asn Ser Met Asp Asn Leu Asp Ser Glu Cys Ser Glu Val
            340                 345                 350         
Tyr Gln Pro Leu Thr Ser Ser Asp Asp Ala Leu Asp Ala Pro Ser Ser
        355                 360                 365             
Ser Glu Ser Glu Gly Ile Pro Ser Ile Glu Arg Ser Arg Lys Gly Ser
    370                 375                 380                 
Ser Gly Asn Ala Ser Glu Val Ser Val Ala Cys Leu Thr Glu Arg Ile
385                 390                 395                 400 
His Gln Met Glu Glu Asn Gln His Ser Thr Ser Glu Glu Leu Gln Ala
                405                 410                 415     
Thr Leu Gln Glu Leu Ala Asp Leu Gln Gln Ile Thr Gln Glu Leu Asn
            420                 425                 430         
Ser Glu Asn Glu Arg Leu Gly Glu Glu Lys Val Ile Leu Met Glu Ser
        435                 440                 445             
Leu Cys Gln Gln Ser Asp Lys Leu Glu His Phe Ser Arg Gln Ile Glu
    450                 455                 460                 
Tyr Phe Arg Ser Leu Leu Asp Glu His His Ile Ser Tyr Val Ile Asp
465                 470                 475                 480 
Glu Asp Val Lys Ser Gly Arg Tyr Met Glu Leu Glu Gln Arg Tyr Met
                485                 490                 495     
Asp Leu Ala Glu Asn Ala Arg Phe Glu Arg Glu Gln Leu Leu Gly Val
            500                 505                 510         
Gln Gln His Leu Ser Asn Thr Leu Lys Met Ala Glu Gln Asp Asn Lys
        515                 520                 525             
Glu Ala Gln Glu Met Ile Gly Ala Leu Lys Glu Arg Ser His His Met
    530                 535                 540                 
Glu Arg Ile Ile Glu Ser Glu Gln Lys Gly Lys Ala Ala Leu Ala Ala
545                 550                 555                 560 
Thr Leu Glu Glu Tyr Lys Ala Thr Val Ala Ser Asp Gln Ile Glu Met
                565                 570                 575     
Asn Arg Leu Lys Ala Gln Leu Glu Asn Glu Lys Gln Lys Val Ala Glu
            580                 585                 590         
Leu Tyr Ser Ile His Asn Ser Gly Asp Lys Ser Asp Ile Gln Asp Leu
        595                 600                 605             
Leu Glu Ser Val Arg Leu Asp Lys Glu Lys Ala Glu Thr Leu Ala Ser
    610                 615                 620                 
Ser Leu Gln Glu Asp Leu Ala His Thr Arg Asn Asp Ala Asn Arg Leu
625                 630                 635                 640 
Gln Asp Ala Ile Ala Lys Val Glu Asp Glu Tyr Arg Ala Phe Gln Glu
                645                 650                 655     
Glu Ala Lys Lys Gln Ile Glu Asp Leu Asn Met Thr Leu Glu Lys Leu
            660                 665                 670         
Arg Ser Asp Leu Asp Glu Lys Glu Thr Glu Arg Ser Asp Met Lys Glu
        675                 680                 685             
Thr Ile Phe Glu Leu Glu Asp Glu Val Glu Gln His Arg Ala Val Lys
    690                 695                 700                 
Leu His Asp Asn Leu Ile Ile Ser Asp Leu Glu Asn Thr Val Lys Lys
705                 710                 715                 720 
Leu Gln Asp Gln Lys His Asp Met Glu Arg Glu Ile Lys Thr Leu His
                725                 730                 735     
Arg Arg Leu Arg Glu Glu Ser Ala Glu Trp Arg Gln Phe Gln Ala Asp
            740                 745                 750         
Leu Gln Thr Ala Val Val Ile Ala Asn Asp Ile Lys Ser Glu Ala Gln
        755                 760                 765             
Glu Glu Ile Gly Asp Leu Lys Arg Arg Leu His Glu Ala Gln Glu Lys
    770                 775                 780                 
Asn Glu Lys Leu Thr Lys Glu Leu Glu Glu Ile Lys Ser Arg Lys Gln
785                 790                 795                 800 
Glu Glu Glu Arg Gly Arg Val Tyr Asn Tyr Met Asn Ala Val Glu Arg
                805                 810                 815     
Asp Leu Ala Ala Leu Arg Gln Gly Met Gly Leu Ser Arg Arg Ser Ser
            820                 825                 830         
Thr Ser Ser Glu Pro Thr Pro Thr Val Lys Thr Leu Ile Lys Ser Phe
        835                 840                 845             
Asp Ser Ala Ser Gln Val Pro Asn Pro Ala Ala Ala Ala Ile Pro Arg
    850                 855                 860                 
Thr Pro Leu Ser Pro Ser Pro Met Lys Thr Pro Pro Ala Ala Ala Val
865                 870                 875                 880 
Ser Pro Met Gln Arg His Ser Ile Ser Gly Pro Ile Ser Thr Ser Lys
                885                 890                 895     
Pro Leu Thr Ala Leu Ser Asp Lys Arg Pro Asn Tyr Gly Glu Ile Pro
            900                 905                 910         
Val Gln Glu His Leu Leu Arg Thr Ser Ser Ala Ser Arg Pro Ala Ser
        915                 920                 925             
Leu Pro Arg Val Pro Ala Met Glu Ser Ala Lys Thr Leu Ser Val Ser
    930                 935                 940                 
Arg Arg Ser Ser Glu Glu Val Lys Arg Asp Ile Ser Ala Gln Glu Gly
945                 950                 955                 960 
Ala Ser Pro Ala Ser Leu Met Ala Met Gly Thr Thr Ser Pro Gln Leu
                965                 970                 975     
Ser Leu Ser Ser Ser Pro Thr Ala Ser Val Thr Pro Thr Thr Arg Ser
            980                 985                 990         
Arg Ile Arg Glu Glu Arg Lys Asp Pro Leu Ser Ala Leu Ala Arg Glu
        995                 1000                1005            
Tyr Gly Gly Ser Lys Arg Asn Ala Leu Leu Lys Trp Cys Gln Lys Lys
    1010                1015                1020                
Thr Glu Gly Tyr Gln Asn Ile Asp Ile Thr Asn Phe Ser Ser Ser Trp
1025                1030                1035                1040
Asn Asp Gly Leu Ala Phe Cys Ala Leu Leu His Thr Tyr Leu Pro Ala
                1045                1050                1055    
His Ile Pro Tyr Gln Glu Leu Asn Ser Gln Asp Lys Arg Arg Asn Phe
            1060                1065                1070        
Met Leu Ala Phe Gln Ala Ala Glu Ser Val Gly Ile Lys Ser Thr Leu
        1075                1080                1085            
Asp Ile Asn Glu Met Val Arg Thr Glu Arg Pro Asp Trp Gln Asn Val
    1090                1095                1100                
Met Leu Tyr Val Thr Ala Ile Tyr Lys Tyr Phe Glu Thr
1105                1110                1115        


<210> 2651
<211> 281
<212> PRT
<213> Homo sapiens

<400> 2651
Met Gly Met Pro Ser Ser Cys Leu Val Lys Ser Arg Leu Ser Phe Pro
 1               5                  10                  15      
Leu His Thr Ser Ala Cys Arg Pro Thr Ser Ile His Arg Pro Pro His
            20                  25                  30          
Gly Pro Leu Asn Gln Leu Thr Ala Lys Ala Thr Val Lys Thr Thr Glu
        35                  40                  45              
Pro His Met Pro Ala Ala Asp Gln Glu Val Asp Pro Gln Cys Gly Arg
    50                  55                  60                  
Lys Asp Trp Thr His Ser Gln Arg Ala Ala Val Arg Arg Cys Asp Pro
65                  70                  75                  80  
Gly Ser Ser Pro Pro Leu Glu Pro Gly Thr Val Leu Leu Asp Asp Thr
                85                  90                  95      
Pro Pro Leu Pro Ala Thr Phe Arg Gln Val Pro Ser Pro Ser Phe Pro
            100                 105                 110         
Pro Pro Ser Arg Pro Cys Leu His Phe Cys Ser Ser Phe Ile Ala Pro
        115                 120                 125             
Gly His Thr His Lys His Val Thr Glu Lys Ile Tyr Pro Lys Ala Arg
    130                 135                 140                 
Arg Arg Pro Pro Asp His Lys Thr Pro Ser Pro Pro Pro Gly Thr Lys
145                 150                 155                 160 
Val Ser Leu Pro Leu Pro Pro Val Cys Ile Gln Pro Gln Glu Gln Ile
                165                 170                 175     
Val Val Pro His Phe Lys Glu Phe Gln Ala Asn Val Trp Arg Ala Glu
            180                 185                 190         
Lys Ser Ile Ser Gln Tyr Ala Leu Gln Leu Phe Arg Gln Ser Thr Ala
        195                 200                 205             
Leu Pro Gly Arg Ser Leu Glu Leu Gly Leu Thr Lys Ala Val Gly Leu
    210                 215                 220                 
Ser Gly His Pro Gly His Asn Pro Glu Leu Ala Leu Thr Gln Glu Pro
225                 230                 235                 240 
Pro Val Ser Asp Val Pro Met Ser Lys Arg Glu Ala Thr Leu Ser Gln
                245                 250                 255     
Thr Trp Thr Gly Cys Pro Gln Cys Pro Val Ala Gln Ser Pro Asp Ser
            260                 265                 270         
Leu Ser Lys Arg Arg Asp Pro Thr Pro
        275                 280     


<210> 2652
<211> 758
<212> PRT
<213> Homo sapiens

<400> 2652
Met Glu Lys Ser Tyr Pro Lys Ser Gln Ser Arg Ala Gly Thr Phe Pro
 1               5                  10                  15      
Pro Asp Thr Phe Ala Ala Phe Val Leu Trp Asp Glu Ala Arg Asp Asp
            20                  25                  30          
Asp Thr Leu Ala Cys Pro Pro Gly Arg Thr Ser Ala Glu Thr Glu Pro
        35                  40                  45              
Gln Gln Pro Pro Pro Val Pro Ser Cys Arg Pro Cys Ser Pro Thr Asp
    50                  55                  60                  
Glu Ser Val Gly Met Phe Gly His Pro Ser Ser Ala Ala Val Val Pro
65                  70                  75                  80  
Gly Ala Val Arg Arg Arg Glu Cys Arg Glu Cys Gly Ser Leu Cys Ser
                85                  90                  95      
Arg Pro Pro Arg Leu Asn Pro Gln Arg Gly Leu Glu Glu Pro Gly Glu
            100                 105                 110         
Leu Gly Cys Tyr Gln Lys Gly Thr Gly Asn Ser Val Pro Leu Thr Ala
        115                 120                 125             
Gln Val Glu Trp Leu Gly Pro Gln Gly Pro Gly Val Gly Pro Pro Ser
    130                 135                 140                 
Ser Leu Ser Gly Cys Asp Ser Gln Pro Ser Ala Glu Phe Leu His Phe
145                 150                 155                 160 
Pro Leu Ser Leu Gly Gln Trp Asp Gln Ser Pro Asp Arg Leu Thr Ala
                165                 170                 175     
Arg Val Gly Cys Val Trp Val Gly Lys Ala Ala Pro Gln Ser Cys His
            180                 185                 190         
Leu Ser Gly Ser Leu Arg Met Ala Gly Ile Arg Glu Leu Arg Val Glu
        195                 200                 205             
Ser Val Pro Ser Ala Trp Asn Ser Ile Val Trp Ala Lys Ala Trp Ile
    210                 215                 220                 
Arg Leu Gly Trp Lys Asp Gly Arg Cys Ser Arg Asn Cys Pro Gly Pro
225                 230                 235                 240 
Arg Leu Ala Ser Ser Pro Gly His Thr Ser His Cys Ser Leu His Leu
                245                 250                 255     
His Pro Gly Gly Pro Ala Gly Arg Gln Ser Pro Cys Glu Ala Leu Gly
            260                 265                 270         
Thr Thr Ile Val Thr Val Thr Gly Val His Val Asp Asp His Val Leu
        275                 280                 285             
Gln Ala Ser Asn Met Leu Ser Thr Ser His Phe Ile Ser Ile Tyr Arg
    290                 295                 300                 
Ser Arg Thr Pro Gln Lys Arg Val Ala Arg Pro Ala Glu Arg Lys Gly
305                 310                 315                 320 
Pro Cys Pro Lys Ser Pro Ser Thr Glu Glu Leu Gly Phe Gln Pro Gln
                325                 330                 335     
Gln Ala Leu Ala Pro Leu Trp Ala Trp Val Leu Thr Lys Ala Leu Pro
            340                 345                 350         
Ser Leu Arg Leu Arg Val Ser Gly Ala Gln Val Gly Val Met Arg Ala
        355                 360                 365             
Lys Gly Gly Gln Thr Gly Asn Gln Glu Glu Gly Met Ser Ser Gly Val
    370                 375                 380                 
Arg Ala Trp Arg Gln Arg Asp Arg Gly Phe Tyr Gly Leu Arg Gly His
385                 390                 395                 400 
Arg Ala Gly Pro Ala Ala Gln Gly Pro Arg Pro Arg Tyr Pro Gln Ala
                405                 410                 415     
Ser Pro Gly Asn Arg Ser Ala Trp Gly Gly Ile Glu Thr Glu Thr Gln
            420                 425                 430         
Cys Cys Ser Pro Ser Ala Val Gly Glu His Arg Val Cys Thr Gly Gly
        435                 440                 445             
Arg Gln Ser Asn Val His Glu Asn Thr Trp Pro Cys Arg Pro Lys Gly
    450                 455                 460                 
Trp Glu Asp Arg Gly His Asp Asp Ile Asn Leu Leu Tyr Gly Asp Gly
465                 470                 475                 480 
Ile His Phe Leu Asp Gly Glu Asp Ile Asn Leu Phe Val Gln Cys Phe
                485                 490                 495     
His Leu Ser Glu Ala Ser Ser His Tyr Leu Pro Pro Leu Ser Leu Thr
            500                 505                 510         
Val Pro Ser Ala Lys Gly Gln Pro Ser Ser Pro Leu Asn Ala Pro Leu
        515                 520                 525             
Gly Ser Ser Pro Leu Ser Gly Ser Ser Val His Arg Ser Leu Thr Gln
    530                 535                 540                 
Arg Glu Ala His Ser Val His Arg Lys Asp Glu Gly Gln Asp Val Trp
545                 550                 555                 560 
Ala Gly Ala Ser Pro Val Gly Gly Asn Asp Leu Asp Asn Glu Gly Asp
                565                 570                 575     
His Ser Leu Val His Glu Thr Pro Asp Thr Arg Pro Gly Leu Cys Leu
            580                 585                 590         
Gln Ser Gln Lys Glu Asp Ala Leu Gly Glu Thr Arg Glu Val Pro Arg
        595                 600                 605             
Gly Asn Gly Cys Pro Gln Gly Ser Ala Arg Leu Pro Val Arg Ala Val
    610                 615                 620                 
Thr Arg Ala Ile Leu Glu His Ala Glu Met Glu Asn Ser Gly His Pro
625                 630                 635                 640 
Ser Ile Leu Phe Ile Ser Val Gly Pro Leu Val Asn Arg Asn Leu Gln
                645                 650                 655     
Tyr Pro Ala Lys Ile Asn Leu Trp Asn Ser Leu Pro Gln Lys Gly Leu
            660                 665                 670         
Gln Thr Arg Asp Met Ser Thr Pro Gly Gln Thr Leu Arg Cys Leu Asp
        675                 680                 685             
Asp Arg Ala Leu Asn Gly Asp Thr Pro Gly Cys Glu Gly Asn Ser Gly
    690                 695                 700                 
Pro Phe Cys Gln Gly Gln Pro Ala Ile Gln Gly Val Arg Ala Thr Pro
705                 710                 715                 720 
Cys Arg Lys Pro Thr Gln His Ser Pro Pro Ala Gly Val Arg Ser Ala
                725                 730                 735     
Trp Pro Ala Ala Gly Ser Gly Gln Asp Ala Pro Ser Gly Asn Thr Gly
            740                 745                 750         
Arg Lys Gly Gly Arg Cys
        755             


<210> 2653
<211> 168
<212> PRT
<213> Homo sapiens

<400> 2653
Met Arg Arg Met Asn Gly Lys Asp Gly Ser Leu Pro Pro Ser Ala Asp
 1               5                  10                  15      
Arg Trp Pro Val Leu Lys Gly Val Cys Val Met Leu Pro Cys Asp His
            20                  25                  30          
Cys Pro Trp Asp Leu Ala Val Ala Leu Gln Val Ile Pro Asp Gly Val
        35                  40                  45              
Gln Asp Ser Val Ala Leu Leu Trp Gly Ser Gln Leu Thr Gly Ala Leu
    50                  55                  60                  
Thr Ile Gly Pro Glu Val Asp Arg Ala Val His Met Val Cys Leu Glu
65                  70                  75                  80  
Asp Val Gly Asn Thr Glu Pro Leu Arg Thr Gly Thr Leu Ser Val Leu
                85                  90                  95      
Ser Ile Thr Val Ser Gln Gly Phe Glu Gln Cys Thr Gly His Met Met
            100                 105                 110         
Tyr Val Cys Gly Leu Asp Asn Gly Leu Ser Thr Ser Lys Ser Val Gly
        115                 120                 125             
Gly Glu Arg Arg Phe Trp Pro Gly His Pro Gln Ala Leu Ala Lys Gly
    130                 135                 140                 
Arg Pro Thr Lys Asp Glu Leu His Gly Leu Arg Cys Arg Met Leu Gln
145                 150                 155                 160 
Ser Val Ala Ala Glu Gly Leu Pro
                165             


<210> 2654
<211> 584
<212> PRT
<213> Homo sapiens

<400> 2654
Met Pro Leu Trp Ala Leu Glu Gly Tyr Lys Gln Val Glu Ser Ser Glu
 1               5                  10                  15      
Pro Glu Ser Val Val Pro Leu Leu Ser Pro Ala Leu Pro Thr Trp Met
            20                  25                  30          
His Lys Leu Gln Ser Thr Leu Gly Cys Ala Glu Ala Pro Leu Glu Pro
        35                  40                  45              
Ser Arg Ala Lys Val Ser Arg Asp Phe Pro Thr Leu Pro Arg Glu Ala
    50                  55                  60                  
Val Pro Thr Pro Glu Gly Pro Leu Asn Asp Met Gly Leu Gly Arg Ala
65                  70                  75                  80  
Gln Ser Pro Glu Pro Glu Ala Gln Leu Glu Thr Pro Thr Gly Arg Lys
                85                  90                  95      
Glu Pro Gly Leu Pro Ser Ser Ser Pro Cys Gly Leu Val Pro Trp Arg
            100                 105                 110         
Ala Gly Pro Ala Gly Val Asn Gln Phe Lys Cys Glu Leu Asp Gly Cys
        115                 120                 125             
Ser Ser Arg Phe Ala Asn Ser Cys Asp Trp Glu Met Ser Thr His Ala
    130                 135                 140                 
His Met Gly Asp Gln Leu Gln Ala Ser Gly Lys Pro Val Ala Thr Arg
145                 150                 155                 160 
Thr Gln Ala Glu Glu Gln Lys Glu Thr Pro Ala Pro Gly Leu Thr Pro
                165                 170                 175     
Glu Gln Pro Leu Pro Arg Leu Tyr Thr Ile Asn Ile Cys Phe Gln Pro
            180                 185                 190         
Asp Arg Ser Arg Phe Leu Thr Gln Leu Val Pro Gly Val Leu Gln Ala
        195                 200                 205             
Tyr Val Pro Leu Glu His Asp Ser Gly Thr Val Arg Glu Pro Ala Ala
    210                 215                 220                 
Ala Gln Pro Gly Asn Ala His Ser Leu Arg Glu Ser Tyr Arg Thr His
225                 230                 235                 240 
Leu Ala Ala Cys Glu Ser Leu Ala Arg Gly Thr Glu Ala Val Gln Lys
                245                 250                 255     
Met Pro Tyr Val Pro Glu Leu Pro Ala Met Ile Ile Gly Ile Ser Arg
            260                 265                 270         
Ala Leu Gly Ser Thr Ser Ser Leu Gly Leu Gln Arg Ala Arg Ser Ser
        275                 280                 285             
Val Asn Lys Gly Gln Ser Ser Leu Ile Gln Trp Leu Ile Phe Thr Arg
    290                 295                 300                 
Asn Ile Arg Arg Leu Pro Gln Gly Asp Val Gly Gln Gln Glu Asp Ser
305                 310                 315                 320 
Val Leu Pro Phe Ile Ser Phe Pro Met Cys Ser Pro Val Gly Lys Val
                325                 330                 335     
Lys Ser Leu Ser Tyr Trp Thr Leu Leu Glu Ser Phe Val His Leu Pro
            340                 345                 350         
Met Arg Ala Leu Lys Glu Gly Leu Ile Pro Thr Thr Phe Ser Leu Pro
        355                 360                 365             
Ser Thr Pro Asn Gly Ile Cys Thr Arg Cys Ser Val Ile Ala His Asn
    370                 375                 380                 
Pro Pro Ala Leu Gly Phe Ala Ser Ser Asp Arg Gln Met Ile Thr Asn
385                 390                 395                 400 
Gly Leu Lys Pro Asn Gln Leu His Leu Lys Arg Leu Gln Pro Lys Trp
                405                 410                 415     
Leu Val Gly Gln Ser Gly Glu Tyr Gly Thr Ala Lys Leu Cys Val Cys
            420                 425                 430         
Phe Ser Val Asp Pro Glu Arg Leu Trp Phe Asn Lys Leu Tyr Phe Thr
        435                 440                 445             
Thr Gln Ile Ala Met Val Leu Thr Glu Lys Leu Pro Leu Ser Glu Lys
    450                 455                 460                 
Gln Leu Lys Asn Pro Thr Leu Ile Cys Tyr Lys Ala Tyr Gly Trp Pro
465                 470                 475                 480 
Phe Leu Glu Glu Thr Ala Ile Phe Leu Gly Lys Lys Asn Val Lys Thr
                485                 490                 495     
Lys Glu Leu Ile Ala Ser Asp Arg Ile Leu Gly Thr Tyr Gln Lys Gln
            500                 505                 510         
Arg Pro Ala Ile Tyr Trp Thr Tyr Met Ser Asp Phe Gln Asp Glu Leu
        515                 520                 525             
Gln Thr Val Gln Leu Gln Lys Thr Val Pro Gln Gly Leu Asn Ser Lys
    530                 535                 540                 
Gln Leu Gly Leu Ser Glu Ile Asn Leu Asp Pro Leu Thr Glu Glu Arg
545                 550                 555                 560 
Arg Tyr Leu Gly Pro Lys Gln Thr Lys Pro Gln Glu Pro Leu His Gly
                565                 570                 575     
Lys Leu Gln Lys Pro Leu Gln Arg
            580                 


<210> 2655
<211> 439
<212> PRT
<213> Homo sapiens

<400> 2655
Met Arg Arg Ala Ala Leu Arg Leu Cys Ala Leu Gly Lys Gly Gln Leu
 1               5                  10                  15      
Thr Pro Gly Arg Gly Leu Thr Gln Gly Pro Gln Asn Pro Lys Lys Gln
            20                  25                  30          
Gly Ile Phe His Ile His Glu Val Arg Asp Lys Leu Arg Glu Ile Val
        35                  40                  45              
Gly Ala Ser Thr Asn Trp Arg Asp His Val Lys Ala Met Glu Glu Arg
    50                  55                  60                  
Lys Leu Leu His Ser Phe Leu Ala Lys Ser Gln Asp Gly Leu Pro Pro
65                  70                  75                  80  
Arg Arg Met Lys Asp Ser Tyr Ile Glu Val Leu Leu Pro Leu Gly Ser
                85                  90                  95      
Glu Pro Glu Leu Arg Glu Lys Tyr Leu Thr Val Gln Asn Thr Val Arg
            100                 105                 110         
Phe Gly Arg Ile Leu Glu Asp Leu Asp Ser Leu Gly Val Leu Ile Cys
        115                 120                 125             
Tyr Met His Asn Lys Ile His Ser Ala Lys Met Ser Pro Leu Ser Ile
    130                 135                 140                 
Val Thr Ala Leu Val Asp Lys Ile Asp Met Cys Lys Lys Ser Leu Ser
145                 150                 155                 160 
Pro Glu Gln Asp Ile Lys Phe Ser Gly His Val Ser Trp Val Gly Lys
                165                 170                 175     
Thr Ser Met Glu Val Lys Met Gln Met Phe Gln Leu His Gly Asp Glu
            180                 185                 190         
Phe Cys Pro Val Leu Asp Ala Thr Phe Val Met Val Ala Arg Asp Ser
        195                 200                 205             
Glu Asn Lys Gly Pro Ala Phe Val Asn Pro Leu Ile Pro Glu Ser Pro
    210                 215                 220                 
Glu Glu Glu Glu Leu Phe Arg Gln Gly Glu Leu Asn Lys Gly Arg Arg
225                 230                 235                 240 
Ile Ala Phe Ser Ser Thr Ser Leu Leu Lys Met Ala Pro Ser Ala Glu
                245                 250                 255     
Glu Arg Thr Thr Ile His Glu Met Phe Leu Ser Thr Leu Asp Pro Lys
            260                 265                 270         
Thr Ile Ser Phe Arg Ser Arg Val Leu Pro Ser Asn Ala Val Trp Met
        275                 280                 285             
Glu Asn Ser Lys Leu Lys Ser Leu Glu Ile Cys His Pro Gln Glu Arg
    290                 295                 300                 
Asn Ile Phe Asn Arg Ile Phe Gly Gly Phe Leu Met Arg Lys Ala Tyr
305                 310                 315                 320 
Glu Leu Ala Trp Ala Thr Ala Cys Ser Phe Gly Gly Ser Arg Pro Phe
                325                 330                 335     
Val Val Ala Val Asp Asp Ile Met Phe Gln Lys Pro Val Glu Val Gly
            340                 345                 350         
Ser Leu Leu Phe Leu Ser Ser Gln Val Cys Phe Thr Gln Asn Asn Tyr
        355                 360                 365             
Ile Gln Val Arg Val His Ser Glu Val Ala Ser Leu Gln Glu Lys Gln
    370                 375                 380                 
His Thr Thr Thr Asn Val Phe His Phe Thr Phe Met Ser Glu Lys Glu
385                 390                 395                 400 
Val Pro Leu Val Phe Pro Lys Thr Tyr Gly Glu Ser Met Leu Tyr Leu
                405                 410                 415     
Asp Gly Gln Arg His Phe Asn Ser Met Ser Gly Pro Ala Thr Leu Arg
            420                 425                 430         
Lys Asp Tyr Leu Val Glu Pro
        435                 


<210> 2656
<211> 488
<212> PRT
<213> Homo sapiens

<400> 2656
Met Val Asp Tyr Leu Gln Thr Glu Gln Lys Gln Asp Arg His Cys Val
 1               5                  10                  15      
Asn Thr Val Ser Leu Leu Pro Gln Tyr Tyr Thr Glu Leu Glu Ile Leu
            20                  25                  30          
Ser Asn Ser Thr Asp Ala Phe Phe Cys Pro Trp Phe Ser His Trp Ile
        35                  40                  45              
Tyr Lys Gly Ile Pro Pro Gln Val Trp Gly Pro Val Trp Ser Leu Leu
    50                  55                  60                  
Met Val Phe Lys Lys Gly Lys Ala Arg Asn Leu Gly Lys Tyr Leu Ile
65                  70                  75                  80  
Trp Pro Asp His Asn Trp Pro Glu Gln Asp Lys His Ala Met Pro Cys
                85                  90                  95      
Gln Ala Pro Ser Tyr Pro Ala Gly Gly Lys Val Ser Pro Glu Arg Val
            100                 105                 110         
Glu Gly Ala Ser His Lys Ser Arg Ile Asp Ser Asp Leu Gly Ser Thr
        115                 120                 125             
Ala Val Ser Ala Val Ser Leu Val Ser Val Met Arg Val Gly Pro Pro
    130                 135                 140                 
Leu Gly Pro Ala Leu Gln Lys Met Met Glu Gln Gly Lys Leu Ser Ser
145                 150                 155                 160 
Val Asn Val His Gln Asn Gly Leu Asp Val Ser His Ala Phe Arg Asn
                165                 170                 175     
His Ala Cys Ser Lys Ser Ala Thr Ala Ser Asn Lys Ala Tyr Gly Gly
            180                 185                 190         
Arg Thr Leu Gly Gly Thr Gly Gly Val Gly Pro Ile Cys Ala Ser Gln
        195                 200                 205             
His Pro Gln Leu Pro Ala Pro Thr Pro Glu Asn Ser Arg Gly Ala Ser
    210                 215                 220                 
Leu Thr Ser Thr Pro Pro Ser Val Ser Arg Arg Gln Ala Leu Ser Gln
225                 230                 235                 240 
Gly Met Glu Arg Ile Ser Val Ser Asp Pro Glu Arg Gly Phe Arg Glu
                245                 250                 255     
Thr Val His Val Thr Pro Gly Gly Pro Leu Glu Thr Pro Lys Thr Pro
            260                 265                 270         
Gly Ala Gln Val His Glu Ala Gln Pro Cys Lys Glu Gln Met Gly Leu
        275                 280                 285             
Val Glu Lys Trp Thr Lys Ser Ala Phe Leu Ser Ala Lys Pro Ala Lys
    290                 295                 300                 
Ile Pro Arg Lys Val Leu Gly Leu Glu Arg Val Ser Leu Ala Pro Arg
305                 310                 315                 320 
Pro Leu Trp Ala Ser Leu Ser Met Gln Thr Leu Pro Lys Gly Asp Gly
                325                 330                 335     
Leu Pro Ser Val Ala His Gln Pro Ser Ser Arg Ser Pro Glu Ala Asp
            340                 345                 350         
Pro Glu Ala Lys Ala Gln Gln His Glu Gly Thr Ser Ala Glu Pro Arg
        355                 360                 365             
Ala Ala Gly His Ser Leu Gly Ala Gln Pro Pro Arg Val Gln Gln Val
    370                 375                 380                 
Cys Ser Tyr Leu Arg Thr Asp Pro Arg Ile Leu Gly Asp Phe Cys Val
385                 390                 395                 400 
Gly Val Leu Ser Gln Asn Ser Pro Cys Thr Trp Thr Ser Arg Ala His
                405                 410                 415     
Gly Phe Tyr Ser Ala Ala Leu Ser Arg His Ala Glu Leu Leu Phe Leu
            420                 425                 430         
Pro His Leu Leu Trp Thr Ser Pro Gly Pro Met Asp Arg Pro Ile Pro
        435                 440                 445             
Ala Thr Pro Ala Gly Leu Gln Gln Pro Asp Pro Ala His Pro Thr Glu
    450                 455                 460                 
Asn Pro Glu Met Thr Asp Asp Gly Tyr Pro His Ile Ala Thr Ser Pro
465                 470                 475                 480 
Pro Thr Leu Val Asp Asn Arg Ile
                485             


<210> 2657
<211> 124
<212> PRT
<213> Homo sapiens

<400> 2657
Met Val Ile Ser Ala Asp Val Val Leu Asp Leu Gly Phe Asn Ser Val
 1               5                  10                  15      
Gly Glu Met Arg Gln Ile Phe Ile Cys Gln Lys Leu Cys Trp Glu Ile
            20                  25                  30          
Ala Cys Arg Lys Leu Pro Pro Lys Thr Asp Glu Tyr Ser His Gly Gly
        35                  40                  45              
Ala Cys Leu Ser Arg Gly Asn Ala Asp Leu Val Trp Ala Leu Lys Lys
    50                  55                  60                  
Ala Pro Trp Asp Ser Tyr Glu Glu Gln Trp Cys Phe Trp Asp Gln Gln
65                  70                  75                  80  
Ala Ile Gly Ser Asp Arg Asp Glu Glu Ala Lys Ser Ser Leu Pro Phe
                85                  90                  95      
Thr Asn Met Asp Asn Tyr Thr Glu Cys Lys Ala Val Glu Arg Leu Arg
            100                 105                 110         
Lys Phe Ser Arg Ser Leu Gly Ser Phe Pro Asn Phe
        115                 120                 


<210> 2658
<211> 209
<212> PRT
<213> Homo sapiens

<400> 2658
Met Arg Leu Gly Ala Gln Thr Ser Pro Cys Gly Val Arg Arg Gly Pro
 1               5                  10                  15      
Gln Ser Leu Gly Phe Pro Gly Arg Ile Pro Val Gly Arg Pro Ser Ser
            20                  25                  30          
Gly Gly Lys Gly Pro Asp Pro Lys Arg Ala Arg Ala Pro Gly Gln Ala
        35                  40                  45              
Leu Pro Arg Ala Leu Cys Val Arg Ile Ala Arg Glu Ala Ala Ala Gly
    50                  55                  60                  
Gln Gly Pro Arg Leu Arg Asp Pro Arg Arg Pro Pro Ala Met Gly Pro
65                  70                  75                  80  
Pro Ser Gln Ser Ala Gly Leu Ser Pro Ala His Met Cys Leu Leu Leu
                85                  90                  95      
Thr Thr Ala Tyr Pro Ser Ala Ser Leu Pro Pro Pro Ser Leu His Pro
            100                 105                 110         
Gly Gly Asn Gly Ala Leu Gly Gln Glu Ala Ala Gly Thr Pro Glu Ala
        115                 120                 125             
Ser Ser Leu Arg Arg Gly Pro Gly Met Pro Thr Gly Thr Pro Val Gly
    130                 135                 140                 
Ala Gly Arg Gly Arg Arg Ala Met Arg Ala Glu Thr Thr Cys Ala Arg
145                 150                 155                 160 
Leu Thr Leu His Ala Val His Ser Pro Gly Ala Leu Gly Gly Ala Glu
                165                 170                 175     
Val Gly Arg Pro Leu Leu Ser Glu Trp Ser Leu Ser Ala Ala Trp Leu
            180                 185                 190         
Gly Arg Gly Gln Thr Trp Val Ala Ser Tyr Gly Phe Pro Phe Pro Gly
        195                 200                 205             
Pro
    


<210> 2659
<211> 164
<212> PRT
<213> Homo sapiens

<400> 2659
Met Ser Ser Cys Pro Val His Asp Cys Pro Ser Trp Asp Pro Glu Arg
 1               5                  10                  15      
Leu Glu Pro Val Glu Thr Gly Ser Arg Gly Ala Leu Arg Leu Arg Gly
            20                  25                  30          
Gly Ala Pro Gly Ser Ala Ala Gly Phe Arg Ala Ser Ile Trp Gly Pro
        35                  40                  45              
Ala Gly Tyr Pro Ser Pro Val Gly Leu Gly His Pro Ala Ser Leu Pro
    50                  55                  60                  
Arg Pro Ala Tyr Ser Pro Arg Cys Pro Glu Pro Asp Ala Arg His Gly
65                  70                  75                  80  
Trp Gly Ser Gly Ser Asn Ala Gly Tyr Arg Gly Pro Asp Arg Ala Gly
                85                  90                  95      
Arg Thr Pro Cys Pro Ala Gln Asp Arg Glu Gly Arg Ser Ser Ser Pro
            100                 105                 110         
Val Pro Pro Pro Arg Leu Lys Ala Met Thr Ser Gln Ala Arg Lys Gln
        115                 120                 125             
Asn Gly Gly Ala Leu Ile Asp Thr Val Asp Trp Thr Arg Glu Ala Pro
    130                 135                 140                 
Asp Ser Asp Pro Val Met Ser Met Gln Lys Thr Gln Lys Pro Gln Thr
145                 150                 155                 160 
Thr Val Gly Gln
                


<210> 2660
<211> 184
<212> PRT
<213> Homo sapiens

<400> 2660
Met Lys Ile Arg Ala Asp Ile Arg Glu Ile Glu Asn Lys Lys Asp Thr
 1               5                  10                  15      
Ile Lys Arg Ile Asn Thr Thr Lys Lys Leu Phe Met Lys Lys His Asn
            20                  25                  30          
Glu His Ser Glu Glu Ile Lys Ile Ile Leu His Lys Ala Glu Glu Gly
        35                  40                  45              
Phe Lys Glu Lys Glu Lys Ser Lys Met Ser Ile Val Ala Phe Val Lys
    50                  55                  60                  
Ala Met Asp Arg Lys Arg Ser Ala Glu Pro Gln Pro Arg Glu Pro Glu
65                  70                  75                  80  
Glu Ala Val Arg Ala Ala Asn Ala Lys Lys Ala Glu Pro Ser Val Pro
                85                  90                  95      
Ala Glu Pro Gly Thr Pro Ser Leu Ala Ala Asp Arg Ser Gly Ser Val
            100                 105                 110         
Leu Gln Ala Leu Gly Arg Ser Ala Ser Ala Ala Gln Arg Leu Thr Cys
        115                 120                 125             
Leu Leu Val Ser Thr Arg Pro Pro Lys Pro Arg Arg Ala Ser Ala Ser
    130                 135                 140                 
Arg Val Ala Ser Lys Leu Ser Leu Cys Cys Cys Gly Asn Leu Pro Asn
145                 150                 155                 160 
Asp His Val Gly Phe Thr Pro Gly Arg Ser Arg His Phe Cys Leu Ser
                165                 170                 175     
Gln Gly Glu Gly Glu Asn Ser Leu
            180                 


<210> 2661
<211> 58
<212> PRT
<213> Homo sapiens

<400> 2661
Met Ala Gly Pro Glu Ser Asp Ala Gln Tyr Gln Phe Thr Gly Ile Lys
 1               5                  10                  15      
Lys Tyr Phe Asn Ser Tyr Thr Leu Thr Gly Arg Met Asn Cys Val Leu
            20                  25                  30          
Val Thr Tyr Arg Ser Ile Ala Leu Ile Val Leu Tyr Phe Lys Leu Arg
        35                  40                  45              
Ser Lys Lys Thr Pro Ala Met Lys Ala Thr
    50                  55              


<210> 2662
<211> 390
<212> PRT
<213> Homo sapiens

<400> 2662
Met Ser Gly Asp Arg Lys Thr Asp Thr His Cys Val Lys Asp Lys Pro
 1               5                  10                  15      
Glu Glu Arg Asp Leu Lys Asp Glu Lys Val Ser Ala Gly Phe Gly Gly
            20                  25                  30          
Arg Gly Ser Glu Pro Asp Asn Leu Thr Ser Glu Gln Gln Val Pro Ser
        35                  40                  45              
Thr Glu Gly Thr Lys Asp Glu Asp Asn Ser Asn Asn Val Asn Asn Ser
    50                  55                  60                  
Ile Ser Asn Ser Lys Met Val Pro Gly Asp Ser Ser Asp Ser Ser Asp
65                  70                  75                  80  
His Ile Leu Thr Val Val Pro Ser Asp Ser Ser Asp His Ile Leu Thr
                85                  90                  95      
Val Val Pro Ser Asp Ser Ser Asp Arg Ile Leu Thr Val Val Pro Gly
            100                 105                 110         
Asp Ser Ser Asp Arg Ile Leu Thr Val Val Pro Gly Asp Ser Ser Asp
        115                 120                 125             
Arg Ile Leu Thr Val Val Pro Gly Asp Ser Ser Asp Arg Ile Leu Thr
    130                 135                 140                 
Val Val Pro Gly Asp Ser Ser Asp Ser Ser Asp His Ile Leu Thr Val
145                 150                 155                 160 
Val Pro Ser Asp Leu Thr Val Val Pro Val Val Pro Gly Asp Ser Ser
                165                 170                 175     
Asp Arg Ile Leu Thr Val Val Pro Ser Asp Ser Ser Asp Arg Ile Leu
            180                 185                 190         
Thr Val Val Pro Tyr Asn Ser Ser Asp Cys Ile Leu Thr Val Val Ser
        195                 200                 205             
Ser Asp Gln Val Leu Thr Val Val Pro Ser Asp Arg Val Leu Met Asp
    210                 215                 220                 
Ala Gly Thr Ser Ile Cys Ser Gln Pro Ala Gly Arg Lys Pro Thr Leu
225                 230                 235                 240 
Ser Thr Cys Trp Phe Pro Ser Gly Lys Arg Cys Ile Ser Lys Lys Ala
                245                 250                 255     
Lys Tyr Pro Glu Lys Ile Leu Ser His Asp Ala Lys Gly Ala Ser Gly
            260                 265                 270         
Gln Lys Asn Gln Pro Asp Gln Gly Arg Cys Cys Leu Arg Phe Asn Lys
        275                 280                 285             
Gly Leu Leu Ala Val Lys Ser Ser Lys Asn Met Gln Ala Pro Ser Arg
    290                 295                 300                 
Gly Gly Ser His Val Lys Trp Ala Lys Asp Val Ser Val Thr Ala Pro
305                 310                 315                 320 
Leu Thr Ala Lys Asn Thr Lys Ser Gln Arg Gly Ala Glu His Lys Ala
                325                 330                 335     
Ser Glu Asp Phe Thr Phe His His Leu Gln Gly Ser Leu Cys Ser Asn
            340                 345                 350         
Leu Glu Leu Met Val Pro Ser Leu Gly Gly Leu Gln Lys Glu Pro Gly
        355                 360                 365             
Gly Lys Arg Met Gln Arg Ser Gln Gly Gln Glu Gly Gly Met Gly Glu
    370                 375                 380                 
Lys Glu Val Cys Leu Pro
385                 390 


<210> 2663
<211> 264
<212> PRT
<213> Homo sapiens

<400> 2663
Met Asp Pro Ala Val Ala Trp Gly Tyr Lys Leu Ala Ser Arg Val Leu
 1               5                  10                  15      
Lys Gln Leu Ala Ser Gly Val Ala Ala Leu Gly Val Arg Ser Arg Thr
            20                  25                  30          
Gln Asn Leu Ser Gln Pro Ser Thr Gly Ile Pro Ser Gly Glu Pro Gly
        35                  40                  45              
His Ser Ala Gly Gly Ala Ala Gly Ser Arg Cys Thr Arg Ser Met Phe
    50                  55                  60                  
Arg Lys Val Pro Asn Asn Ala Ser Ala Leu Ile Gly Ser Glu Leu Glu
65                  70                  75                  80  
His Gly Cys Ser Arg Gln Gly Gly Gly Cys Ser Pro Gln Pro Gly Val
                85                  90                  95      
Gln Pro Ser Thr His Leu Ser Pro Pro Glu Ser Cys Ser Ile Gly Ser
            100                 105                 110         
Ser Val Leu Trp Ala Leu Trp Ser His Pro Gln Arg Glu Gly Phe Gly
        115                 120                 125             
Val Thr Ser Val Gly Gln Leu His Lys Gly Pro Ala Cys Leu Cys Val
    130                 135                 140                 
Tyr Pro Gly Asn Cys Arg Met Ala His Ala Glu Gln Lys Leu Met Asp
145                 150                 155                 160 
Asp Leu Leu Asn Lys Thr Arg Tyr Asn Asn Leu Ile Cys Pro Ala Thr
                165                 170                 175     
Ser Ser Ser Gln Leu Ile Ser Ile Glu Thr Glu Leu Ser Leu Ala Gln
            180                 185                 190         
Cys Ile Ser Val Leu Ala Gln Gln Val Thr Leu Gln Ala Pro Tyr Leu
        195                 200                 205             
Leu Gly Glu Ile Arg Thr Lys Leu Arg Glu Leu Thr Gly Thr Val Ala
    210                 215                 220                 
Gln Glu Glu Ala Gln Leu Lys Asp Ala Lys Gly Ser Arg Val Val Tyr
225                 230                 235                 240 
Ala Pro Pro Pro Leu Ser Thr Val Arg Ser Glu Arg Arg Gly Leu Ser
                245                 250                 255     
Ala Arg Leu Ala Gln Thr Gly Val
            260                 


<210> 2664
<211> 101
<212> PRT
<213> Homo sapiens

<400> 2664
Met Arg Ala Ala Arg Leu Pro Gly Pro Ser His Leu Leu Pro Glu Gly
 1               5                  10                  15      
Arg Arg Gly Pro Pro Ala Gly Thr Pro Gly Ala Gly Val Ser Ser Ala
            20                  25                  30          
Ser Ala Arg Arg Arg Thr Trp Ala His Gln Thr Gln Thr Ala Ala Glu
        35                  40                  45              
Thr Ser Gln Glu Ala Ser Ser His Pro Ala Gly Lys Leu Pro Ala Gln
    50                  55                  60                  
Ser Cys Val Glu Glu Ser Met Gly Ser Asp Leu Thr Pro Thr Ser Thr
65                  70                  75                  80  
Ala Val Ser Thr Pro Leu His Gln Arg Glu Asp Gly Ala Ser Val Leu
                85                  90                  95      
Gly Thr Leu Gly Ser
            100     


<210> 2665
<211> 1596
<212> PRT
<213> Homo sapiens

<400> 2665
Met Leu Arg Pro Gly Asn Val Ala Gly Arg Gln Leu Arg Glu Val Pro
 1               5                  10                  15      
Asn Ala Lys Gly His Thr Ala Ala Ala Ile Val Pro Gln Tyr Pro Thr
            20                  25                  30          
Pro Gly Ser Ala Gly Ala Glu Val Pro Gly Leu Glu Gly Ala Glu Val
        35                  40                  45              
Pro Gly Leu Glu Gly Ala Glu Val Pro Gly Leu Glu Gly Ala Glu Val
    50                  55                  60                  
Pro Gly Leu Glu Gly Ala Glu Val Pro Gly Val Glu Gly Ala Glu Val
65                  70                  75                  80  
Pro Gly Leu Glu Gly Ala Glu Val Pro Gly Val Glu Gly Ala Glu Val
                85                  90                  95      
Pro Gly Leu Glu Gly Ala Glu Val Pro Gly Val Glu Gly Ala Glu Val
            100                 105                 110         
Pro Gly Leu Glu Gly Ala Glu Val Pro Gly Val Glu Asp Ala Glu Val
        115                 120                 125             
Pro Gly Leu Glu Gly Ala Glu Val Pro Gly Val Glu Gly Ala Glu Val
    130                 135                 140                 
Pro Gly Leu Glu Gly Ala Glu Val Pro Gly Val Glu Gly Ala Glu Val
145                 150                 155                 160 
Pro Gly Val Glu Gly Ala Glu Val Pro Gly Leu Glu Gly Ala Glu Val
                165                 170                 175     
Pro Gly Leu Glu Gly Ala Glu Val Pro Gly Val Glu Gly Ala Glu Val
            180                 185                 190         
Pro Gly Val Glu Asp Ala Glu Val Pro Gly Val Glu Gly Ala Glu Val
        195                 200                 205             
Pro Gly Leu Glu Gly Ala Glu Val Pro Gly Leu Glu Gly Ala Glu Val
    210                 215                 220                 
Pro Gly Val Glu Gly Ala Glu Val Pro Gly Val Glu Gly Ala Glu Val
225                 230                 235                 240 
Pro Gly Leu Glu Gly Ala Glu Val Pro Gly Val Glu Asp Ala Glu Val
                245                 250                 255     
Pro Gly Leu Glu Gly Ala Glu Val Pro Gly Leu Glu Gly Ala Glu Val
            260                 265                 270         
Pro Gly Leu Glu Gly Ala Glu Val Pro Gly Leu Glu Asp Ala Glu Val
        275                 280                 285             
Pro Gly Val Glu Gly Ala Glu Val Pro Gly Leu Glu Asp Ala Glu Val
    290                 295                 300                 
Pro Gly Val Glu Gly Ala Glu Val Pro Gly Leu Glu Gly Ala Glu Val
305                 310                 315                 320 
Pro Gly Val Glu Gly Ala Glu Val Pro Gly Val Glu Gly Ala Glu Val
                325                 330                 335     
Pro Gly Val Glu Gly Ala Glu Val Pro Gly Leu Glu Asp Ala Glu Val
            340                 345                 350         
Pro Gly Val Glu Gly Ala Glu Val Pro Gly Leu Glu Gly Ala Glu Val
        355                 360                 365             
Pro Gly Val Glu Gly Ala Glu Val Pro Gly Val Glu Gly Ala Glu Val
    370                 375                 380                 
Pro Gly Leu Glu Gly Ala Glu Val Pro Gly Val Glu Gly Ala Glu Val
385                 390                 395                 400 
Pro Gly Val Glu Asp Ala Glu Val His Gly Leu Glu Gly Ala Glu Val
                405                 410                 415     
Pro Gly Leu Glu Gly Ala Glu Val Pro Gly Val Glu Gly Ala Glu Val
            420                 425                 430         
Pro Gly Val Glu Gly Ala Glu Val Pro Asp Val Glu Gly Ala Glu Val
        435                 440                 445             
Pro Gly Val Glu Gly Ala Glu Val Pro Gly Leu Glu Gly Ala Glu Val
    450                 455                 460                 
Pro Gly Leu Glu Gly Ala Glu Val Pro Gly Val Glu Gly Ala Glu Ile
465                 470                 475                 480 
Arg Gly Leu Glu Gly Ala Glu Val Pro Gly Val Glu Gly Ala Glu Val
                485                 490                 495     
Pro Gly Leu Glu Gly Ala Glu Val Pro Gly Leu Glu Gly Ala Glu Val
            500                 505                 510         
Pro Gly Val Glu Gly Ala Glu Val Pro Gly Leu Glu Asp Ala Glu Val
        515                 520                 525             
Pro Gly Val Glu Gly Ala Glu Val Pro Gly Leu Glu Gly Ala Glu Val
    530                 535                 540                 
Pro Gly Val Glu Gly Ala Glu Val Pro Gly Leu Glu Asp Ala Glu Val
545                 550                 555                 560 
Pro Gly Val Glu Gly Ala Glu Val Pro Gly Val Glu Gly Ala Glu Val
                565                 570                 575     
Pro Gly Val Glu Gly Ala Glu Val Pro Gly Val Glu Gly Ala Glu Val
            580                 585                 590         
Pro Gly Leu Glu Gly Ala Glu Val Pro Gly Leu Glu Gly Ala Lys Val
        595                 600                 605             
Pro Arg Leu Glu Gly Ala Glu Val Pro Asp Val Glu Gly Ala Glu Val
    610                 615                 620                 
Pro Gly Leu Glu Gly Ala Glu Val Pro Gly Val Glu Gly Ala Glu Val
625                 630                 635                 640 
Arg Gly Leu Glu Gly Ala Glu Val Pro Gly Leu Glu Gly Ala Glu Val
                645                 650                 655     
Pro Asp Val Glu Gly Ala Glu Val Pro Gly Leu Glu Gly Ala Glu Val
            660                 665                 670         
Pro Gly Val Glu Gly Ala Glu Val Pro Gly Leu Glu Asp Ala Glu Val
        675                 680                 685             
Pro Gly Val Glu Gly Ala Glu Val Pro Gly Leu Asp Gly Ala Glu Val
    690                 695                 700                 
Pro Gly Leu Glu Gly Ala Lys Val Pro Gly Leu Glu Gly Ala Glu Val
705                 710                 715                 720 
Pro Asp Val Glu Gly Ala Glu Ile Arg Gly Leu Glu Gly Ala Glu Val
                725                 730                 735     
Pro Gly Leu Glu Asp Ala Glu Val Pro Gly Val Glu Gly Ala Glu Val
            740                 745                 750         
Pro Gly Val Glu Gly Ala Glu Val Pro Gly Val Glu Gly Ala Glu Val
        755                 760                 765             
Pro Gly Val Glu Gly Ala Glu Val Pro Gly Val Glu Gly Ala Glu Val
    770                 775                 780                 
Pro Gly Val Lys Gly Ala Glu Val Pro Asp Val Glu Gly Ala Glu Val
785                 790                 795                 800 
Pro Ala Ser Ala Leu Val Val Met Ala Val Ser Ser Asp Phe Gly Phe
                805                 810                 815     
Arg Val Arg Leu Asp Pro Pro Arg Gly Pro Val Thr Val Glu Gly Arg
            820                 825                 830         
Ser Ala Thr Thr Ser Gly Tyr Pro Thr Lys Val Thr Lys Ile Gly Gly
        835                 840                 845             
Pro Leu Asp Pro Ala Gly Gly Leu Glu Gly Pro Leu His Gly Ala Leu
    850                 855                 860                 
Gly Ser Asp Pro Leu Glu Val Ser Asp Cys Pro Gly Pro His Leu Ser
865                 870                 875                 880 
Arg Lys Val Trp Glu Asn Gly Ser Phe Gly Ala Ser Asp Gln Gln His
                885                 890                 895     
Thr Arg Ile Pro Gln Thr Ala Ala Ala Gly Pro Gln Trp Gln Lys Arg
            900                 905                 910         
Lys Leu Pro Arg Gln Asn Ser Ile Thr Ala Ala Trp Arg Pro Arg Asp
        915                 920                 925             
Lys Arg Gly Thr Val Thr Thr Arg Glu Ile Val Pro His Ala Ala Arg
    930                 935                 940                 
Tyr Arg Pro Met Arg Thr Thr Arg Glu Ile Val Pro His Thr Arg Pro
945                 950                 955                 960 
Glu Gln Pro Glu Lys Ser Ser His Thr Gln Pro Arg Thr Phe Gln Arg
                965                 970                 975     
Glu Gln Pro Glu Lys Ser Ser His Thr Trp Pro Gly Thr Ile Arg Arg
            980                 985                 990         
Glu Gln Pro Glu Lys Ser Tyr Pro Thr Arg Pro Gly Thr Ile Arg Arg
        995                 1000                1005            
Glu Gln Pro Glu Lys Ser Tyr Pro Thr Arg Pro Gly Thr Phe Arg Gln
    1010                1015                1020                
Glu Gln Pro Glu Lys Ser Phe His Thr Cys Asn Gln Val Pro Ser Asp
1025                1030                1035                1040
Asn Asn Asn His Arg Asn His Pro Pro Arg Gly Gln Val Pro Ser Asn
                1045                1050                1055    
Glu Asn Asp Gln Val Pro Ser Asp Lys Asn Asn Gln Val Pro Ser Asp
            1060                1065                1070        
Glu Asn Asp Pro Arg Asn Cys Pro Thr Cys Ser His Val Pro Ser Asn
        1075                1080                1085            
Glu Asn Asn Pro Arg Asn His Pro Thr His Gly His Ile Pro Ser Asn
    1090                1095                1100                
Glu Asn Asn Gln Tyr Leu Pro Met Arg Thr Thr Ser Gln Val Pro Ser
1105                1110                1115                1120
Asn Glu Asp Asn Gln Val Ser Ser Asp Lys Asn Asn Gln Ala Pro Ser
                1125                1130                1135    
Asn Glu Asn Asn Gln Lys Val Gln Trp Gly Ser Gly Cys Arg Ala Gly
            1140                1145                1150        
Asn Ala Leu His Ser Phe Ser Val Ala Cys Met Gly Leu Glu Pro Leu
        1155                1160                1165            
Lys Thr Lys Ala Gln Cys Thr Trp Met Leu Val Asn Pro Lys Val Pro
    1170                1175                1180                
Tyr Gly Ala Thr Ser Gly Pro Thr Ser Ser Asp Asp Gly Arg Ser His
1185                1190                1195                1200
Gly His Ala Asn Phe Asp Ser Leu Arg Thr Thr Arg Ala Asn Asp Ser
                1205                1210                1215    
Phe Gln Thr Ser Pro Gly Leu Ala Val Ile Ala Ala Leu Ile Val Val
            1220                1225                1230        
Gly Pro Leu Leu Glu Ala Ser Trp Arg Lys Leu Pro Ser Ala Leu Thr
        1235                1240                1245            
Val Gly Asn Arg Asp Pro Leu Gln Thr Arg Asp Thr His Gly Leu Gln
    1250                1255                1260                
Glu Thr Gly Thr His Tyr Arg His Gly Thr His Thr Gly Tyr Arg Lys
1265                1270                1275                1280
Pro Gly Pro Ile Thr Asp Thr Gly His Thr Arg Phe Thr Gly Asn Arg
                1285                1290                1295    
Asp Pro Leu Gln Thr Arg Asp Thr His Gly Leu Asp Pro Ala Ser Arg
            1300                1305                1310        
Arg Cys Gln Arg Asp Ala Arg Leu Asp Ser Ala Ser Arg Arg Cys Gln
        1315                1320                1325            
Pro Asp Ala Glu Gln Arg Thr Leu Val Lys Glu Gln Leu Gly Gly Val
    1330                1335                1340                
Cys Ser Ala Glu Ala Gln Ser Arg Arg Gly Arg Leu Cys Thr Arg Thr
1345                1350                1355                1360
Trp Arg Leu Arg Gly His Glu Thr Pro Arg Val Arg Asp Lys Gly Ser
                1365                1370                1375    
Glu Trp Pro Ser Arg Ala Glu Gly Thr Glu Ala Ala Arg Gly Arg Ser
            1380                1385                1390        
Leu Arg Thr Glu Arg His Gly His Asp Trp Lys Ala Gln Thr Arg Val
        1395                1400                1405            
Thr Ser Pro Gln Pro Arg Ser Glu Ala Ala Gly Trp Arg Ala Ala Pro
    1410                1415                1420                
Cys Thr Glu Leu Arg Pro Arg Val Glu Gly Asp Gly His Trp Arg His
1425                1430                1435                1440
Gly Val Tyr Cys Ala Leu Asp Leu Val Val Ala Thr Leu Met Phe Thr
                1445                1450                1455    
Arg Gly His Val Gly Ala Arg Cys Pro Leu Cys Val Leu Leu Cys Ala
            1460                1465                1470        
Gln Glu Thr Gly Ala Pro Ala Gly Val Gly Gly Gly Ala Cys Arg Pro
        1475                1480                1485            
Arg Ser Pro Thr Asp Pro Gly Pro Thr Glu Arg Ser Thr Trp Arg Pro
    1490                1495                1500                
Leu Leu Ser Gln Pro Pro His His Pro Leu Ser Leu Leu Arg Gln Arg
1505                1510                1515                1520
Tyr Pro Arg Pro Arg Val Arg Ser Arg Ser Pro Gly Gly Arg Cys Pro
                1525                1530                1535    
Arg Gln Pro Pro Ala Pro Tyr Ala Glu Leu Gln Gln Gly Pro Pro Glu
            1540                1545                1550        
Ala Pro Thr Val Gly Gly Pro Cys Ile His Ala Thr Asn Asn Tyr Gly
        1555                1560                1565            
Ala Pro Ala Phe Arg Gly Pro Trp Ser Gln Val Leu Gly Thr Arg Leu
    1570                1575                1580                
Leu Ala Gly Arg Thr Arg Ser Arg Pro Leu Leu Ser
1585                1590                1595    


<210> 2666
<211> 165
<212> PRT
<213> Homo sapiens

<400> 2666
Met Val Lys Val Gly Thr Asn Gly Phe Gly Arg Ile Gly Arg Leu Val
 1               5                  10                  15      
Ser Arg Ala Ala Phe Asn Ser Glu Ser Thr Ser Ile Phe Thr Thr Met
            20                  25                  30          
Glu Lys Ala Gly Thr His Leu Gln Arg Gly Ala Lys Arg Asn Ile Ile
        35                  40                  45              
Pro Ala Ser Thr Gly Ala Ala Lys Ala Ala Gly Lys Val Ile Pro Glu
    50                  55                  60                  
Leu Asn Gly Lys Leu Thr Cys Met Ala Phe Ser Val Pro Ala Ala Asn
65                  70                  75                  80  
Val Ser Val Val Asp Leu Thr Cys Arg Leu Glu Lys Pro Val Glu Tyr
                85                  90                  95      
Asp Asp Ile Lys Lys Gly Ile Trp Gly Tyr Thr Glu His Gln Val Val
            100                 105                 110         
Ser Ser Asp Phe Asn Arg Asp Thr His Ser Ser Thr Phe Asp Ala Gly
        115                 120                 125             
Ala Gly Ile Ala Leu Asn Asp His Phe Val Lys Leu Val Ser Trp Tyr
    130                 135                 140                 
Glu Asn Glu Phe Gly Tyr Ser Asn Arg Val Ala Asp Leu Met Ala His
145                 150                 155                 160 
Met Ala Ser Lys Glu
                165 


<210> 2667
<211> 315
<212> PRT
<213> Homo sapiens

<400> 2667
Met Ser Ala Glu Arg Ala Gln Ser Thr Ala Glu His Cys Met Phe Met
 1               5                  10                  15      
Ala Trp Thr Ser Leu Leu Asn Arg Glu Asn Ile Tyr Leu Pro Val Asp
            20                  25                  30          
Cys Leu Pro Tyr Thr Lys Gln Gly Asn Gly Asn Ile Thr Glu Thr Lys
        35                  40                  45              
Glu Asn Asp Pro Pro Val Gln Trp Val Gln Thr Gly Asp Phe Ser Trp
    50                  55                  60                  
Ile His Pro Ser Gly Gly Phe Cys Leu Ala Thr Thr Leu Phe Gly Lys
65                  70                  75                  80  
Asn Leu Asp Leu Ile Ile Leu Gly Gln Leu Val Ile Val Ser Ala Phe
                85                  90                  95      
His Ile Ser Met Tyr Pro Gln Ile Pro Ile Ser Ser Ala Glu Lys Ala
            100                 105                 110         
Phe Gly Phe Asp Ser His Pro Leu Ser Ser Pro Gln Gln Glu Glu Asn
        115                 120                 125             
Val Arg Glu Pro Leu Arg Pro Cys Phe Leu Thr Arg Arg Lys Val Ala
    130                 135                 140                 
Asp Thr Ala Met Ile Thr Pro Asn Leu Glu Ala Gln Thr Arg Val Ala
145                 150                 155                 160 
Pro Asn Pro Trp Gly Gln Gly Gln Lys Val Asp Val Ala Thr Gln Thr
                165                 170                 175     
Ala Gly Glu Gly Gly Gly Lys Val Thr Phe Lys Thr Gly Gly Pro Glu
            180                 185                 190         
His Arg Ser Asp Pro Asn Thr Asp Leu Thr Pro Ser Thr Asp Leu Thr
        195                 200                 205             
Pro Ser Thr Asp Leu Thr Pro Ser Thr Asp Leu Thr Pro Asn Thr Asp
    210                 215                 220                 
Leu Ile Pro Asn Thr Asp Leu Thr Pro Asn Thr Asp Leu Thr Pro Ser
225                 230                 235                 240 
Thr Asp Leu Thr Pro Asn Thr Asp Leu Ile Pro Asn Thr Asp Leu Thr
                245                 250                 255     
Pro Asn Thr Asp Leu Thr Pro Ser Thr Asp Leu Thr Pro Ser Ala Asp
            260                 265                 270         
Leu Thr Pro Ser Thr Asp Leu Thr Pro Ser Thr Asp Leu Thr Pro Arg
        275                 280                 285             
Cys Gly Pro Asn Pro Gln His Arg Pro Asp Pro Gln His Gly Pro Asp
    290                 295                 300                 
Pro Gln His Arg Pro Asp Pro Arg Ala Arg Thr
305                 310                 315 


<210> 2668
<211> 522
<212> PRT
<213> Homo sapiens

<400> 2668
Met Leu Ser Val Cys Val Ser Ala Ala Val Ala Arg Asp Leu Thr Arg
 1               5                  10                  15      
Lys Glu Gly Gly Ile Val Lys Arg Thr Gly Thr Ile Val Asp Val Pro
            20                  25                  30          
Val Gly Glu Glu Leu Leu Gly Arg Val Val Asp Ala Leu Gly Asn Ala
        35                  40                  45              
Ile Asp Gly Lys Gly Pro Met Gly Ser Lys Thr His Lys Ile Ile Pro
    50                  55                  60                  
Arg Thr Ser Val Trp Glu Pro Met Pro Thr Gly Ile Lys Ala Val Asp
65                  70                  75                  80  
Ser Leu Val Pro Ile Gly Arg Gly Gln His Glu Leu Ile Ile Gly Asp
                85                  90                  95      
Arg Arg Thr Gly Lys Thr Ser Ile Ala Ile Asp Thr Ile Ile Asn Gln
            100                 105                 110         
Lys His Phe Asn Asp Arg Ser Glu Glu Lys Lys Lys Leu Tyr Cys Ile
        115                 120                 125             
Tyr Val Ala Ile Gly Arg Lys Arg Ser Thr Val Ala Gln Leu Val Lys
    130                 135                 140                 
Arg Leu Thr Asp Ala Asp Ala Val Lys Tyr Thr Thr Val Val Ser Ala
145                 150                 155                 160 
Met Ala Ser Asp Ala Ala Leu Leu Gln Tyr Leu Ala Pro Tyr Ser Asp
                165                 170                 175     
Cys Ser Met Gly Glu Tyr Phe Arg Asp Asp Gly Lys Tyr Thr Leu Ile
            180                 185                 190         
Ile Tyr Asp Asp Leu Ser Lys Gln Ala Val Ala Tyr Cys Gln Met Ser
        195                 200                 205             
Leu Leu Leu His Arg Pro Pro Trp Ser Thr Met Lys Gln Ala Ala Gly
    210                 215                 220                 
Thr Met Lys Leu Glu Leu Ala Gln Asp Arg Glu Val Ala Ala Phe Ala
225                 230                 235                 240 
Gln Phe Gly Ser Asp Leu Asn Ala Pro Thr Gln Gln Leu Leu Ser Arg
                245                 250                 255     
Gly Val Arg Leu Thr Glu Leu Leu Lys Gln Gly Gln Tyr Pro Pro Met
            260                 265                 270         
Val Thr Glu Gln Gln Val Ala Val Ile Cys Ala Gly Gly Glu Asn Ile
        275                 280                 285             
Glu Asp Ile Pro Lys Glu Val Leu Thr Asp Cys Ala His Leu Val Lys
    290                 295                 300                 
Ala Asn Ser Thr Gln Gly Cys Lys Asn Asn Val Asn Val Val Asn Thr
305                 310                 315                 320 
Pro Arg Ser Asn Leu Lys Lys Thr Ala Asp Val Asp Val Arg Gln Ile
                325                 330                 335     
Gly Phe His Arg Gln Lys Asp Val Lys Ile Val Thr Met Glu Lys Lys
            340                 345                 350         
Arg Gly Phe Leu Ala His Ile Trp Asn Lys Glu Val Gln Asp Leu Ile
        355                 360                 365             
Arg Asp Tyr Leu Glu Glu Gly Lys Lys Trp Trp Ile Gly Gln Asn Val
    370                 375                 380                 
Met Pro Leu Lys Lys His Gln Asp Asn Lys Tyr Pro Ala Asp Val Ala
385                 390                 395                 400 
Ala Asn Gly Pro Pro Lys Pro Leu Ser Cys Thr Tyr Leu Ser Arg Asn
                405                 410                 415     
Phe Ile Arg Ile Ser Ser Lys Gly Asp Lys Cys Leu Leu Lys Tyr Tyr
            420                 425                 430         
Phe Ile Cys Gln Thr Gly Asp Phe Leu Asp Gly Asp Ala His Tyr Glu
        435                 440                 445             
Arg Asn Gly Asn Asn Ser His Leu Tyr Gln Arg His Lys Lys Thr Lys
    450                 455                 460                 
Arg Gly Val Ala Ile Ala Arg Asp Lys Met Pro Pro Asp Phe Gln Asp
465                 470                 475                 480 
His Val Ile Pro Gly Gln Glu Ile Lys Ala Lys Ser Phe Tyr Ser Pro
                485                 490                 495     
Val Asp Ser Asp Glu Thr Gly Asp Lys Ile Arg Tyr Asn Ser Lys Arg
            500                 505                 510         
Arg His Trp Arg Thr Gly Met Leu Gly Leu
        515                 520         


<210> 2669
<211> 129
<212> PRT
<213> Homo sapiens

<400> 2669
Met Ala Leu Lys Ala Phe Arg Lys Cys Met Cys Gly Pro Ser Ser His
 1               5                  10                  15      
Glu His Val Leu Ser Gln Glu Met Pro Ile Val Leu Lys Cys Leu Gly
            20                  25                  30          
Ser Pro Ala Gly Pro Pro Leu Gly Phe Pro Pro His Ile Val Phe Val
        35                  40                  45              
Leu Ser Lys Ser Trp Leu Val Ala Leu Pro Glu His Phe Val Leu Gly
    50                  55                  60                  
Thr Ser Leu Gly Pro Gly His Lys Glu Lys Ser Asn Thr Ala Pro Ser
65                  70                  75                  80  
Gln Phe Phe Glu Lys Gln Gln Gln Arg Glu His Asn Cys His Asn Ser
                85                  90                  95      
Pro Ala Pro Gln Gln Asn Ile Cys Lys Ala Arg Cys His Met Ser Cys
            100                 105                 110         
Ser Leu Met Leu Pro Val Thr Gly Ile Gln Gln Asp Leu Trp Ala Pro
        115                 120                 125             
Leu
    


<210> 2670
<211> 192
<212> PRT
<213> Homo sapiens

<400> 2670
Met Thr Ser Ala Ser Thr Lys Val Gly Glu Ile Phe Ser Ala Ala Gly
 1               5                  10                  15      
Ala Ala Phe Thr Lys Leu Gly Glu Leu Thr Met Gln Leu His Pro Val
            20                  25                  30          
Ala Asp Ser Ser Pro Ala Gly Ala Lys Trp Thr Glu Thr Glu Ile Glu
        35                  40                  45              
Met Leu Arg Ala Ala Val Lys Arg Phe Gly Asp Asp Leu Asn His Ile
    50                  55                  60                  
Ser Cys Val Ile Lys Glu Arg Thr Val Ala Gln Ile Lys Ala Thr Val
65                  70                  75                  80  
Lys Arg Lys Val Tyr Glu Asp Ser Gly Ile Pro Leu Pro Ala Glu Ser
                85                  90                  95      
Pro Lys Lys Gly Pro Lys Lys Val Ala Ser Gly Val Leu Ser Pro Pro
            100                 105                 110         
Pro Ala Ala Pro Pro Pro Ser Ser Ser Ser Val Pro Glu Ala Gly Gly
        115                 120                 125             
Pro Pro Ile Lys Lys Gln Lys Ala Asp Val Thr Leu Ser Ala Leu Asn
    130                 135                 140                 
Asp Ser Asp Ala Asn Ser Asp Val Val Asp Ile Glu Gly Leu Gly Glu
145                 150                 155                 160 
Thr Pro Pro Ala Lys Lys Leu Asn Phe Asp Gln Asp Ser Leu Thr Leu
                165                 170                 175     
Asp Ser Gly Leu Leu Met Thr Ser Ala Asp Pro Pro Leu Leu Ser Cys
            180                 185                 190         


<210> 2671
<211> 112
<212> PRT
<213> Homo sapiens

<400> 2671
Arg Leu Gly Gln Arg Pro Cys Arg Glu Pro Val Leu Pro Ala Gly Ala
 1               5                  10                  15      
Ala Cys Arg Arg Gly Pro Arg Pro His Val Asn Gln Ala Arg Arg Arg
            20                  25                  30          
Ser Pro Ala Leu Glu Thr Pro Arg Arg Lys Ala Val Leu Leu Ala Pro
        35                  40                  45              
Ser Ser Ala Arg Pro His Phe Pro Gly Pro Arg Gly Thr Gln Leu Gly
    50                  55                  60                  
Leu Pro Pro Pro Glu Arg Pro Ser Thr Leu Val Leu Tyr Arg Val Arg
65                  70                  75                  80  
Leu Arg Glu Val Pro Gly Ala Pro Gly Pro Cys Leu Ala Pro Tyr Asp
                85                  90                  95      
Leu Trp Ala Arg Gly Gln Leu Leu Pro Met Pro Ala Val Pro Ala Pro
            100                 105                 110         


<210> 2672
<211> 704
<212> PRT
<213> Homo sapiens

<400> 2672
Met Ala Arg Glu Leu Arg Ala Leu Leu Leu Trp Gly Arg Arg Leu Arg
 1               5                  10                  15      
Pro Leu Leu Arg Ala Pro Ala Leu Ala Ala Val Pro Gly Gly Lys Pro
            20                  25                  30          
Ile Leu Cys Pro Arg Arg Thr Thr Ala Gln Leu Gly Pro Arg Arg Asn
        35                  40                  45              
Pro Ala Trp Ser Leu Gln Ala Gly Arg Leu Phe Ser Thr Gln Thr Ala
    50                  55                  60                  
Glu Asp Lys Glu Glu Pro Leu His Ser Ile Ile Ser Ser Thr Glu Ser
65                  70                  75                  80  
Val Gln Gly Ser Thr Ser Lys His Glu Phe Gln Ala Glu Thr Lys Lys
                85                  90                  95      
Leu Leu Asp Ile Val Ala Arg Ser Leu Tyr Ser Glu Lys Glu Val Phe
            100                 105                 110         
Ile Arg Glu Leu Ile Ser Asn Ala Ser Asp Ala Leu Glu Lys Leu Arg
        115                 120                 125             
His Lys Leu Val Ser Asp Gly Gln Ala Leu Pro Glu Met Glu Ile His
    130                 135                 140                 
Leu Gln Thr Asn Ala Glu Lys Gly Thr Ile Thr Ile Gln Asp Thr Gly
145                 150                 155                 160 
Ile Gly Met Thr Gln Glu Glu Leu Val Ser Asn Leu Gly Thr Ile Ala
                165                 170                 175     
Arg Ser Gly Ser Lys Ala Phe Leu Asp Ala Leu Gln Asn Gln Ala Glu
            180                 185                 190         
Ala Ser Ser Lys Ile Ile Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala
        195                 200                 205             
Phe Met Val Ala Asp Arg Val Glu Val Tyr Ser Arg Ser Ala Ala Pro
    210                 215                 220                 
Gly Ser Leu Gly Tyr Gln Trp Leu Ser Asp Gly Ser Gly Val Phe Glu
225                 230                 235                 240 
Ile Ala Glu Ala Ser Gly Val Arg Thr Gly Thr Lys Ile Ile Ile His
                245                 250                 255     
Leu Lys Ser Asp Cys Lys Glu Phe Ser Ser Glu Ala Arg Val Arg Asp
            260                 265                 270         
Val Val Thr Lys Tyr Ser Asn Phe Val Ser Phe Pro Leu Tyr Leu Asn
        275                 280                 285             
Gly Arg Arg Met Asn Thr Leu Gln Ala Ile Trp Met Met Asp Pro Lys
    290                 295                 300                 
Asp Val Arg Glu Trp Gln His Glu Glu Phe Tyr Arg Tyr Val Ala Gln
305                 310                 315                 320 
Ala His Asp Lys Pro Arg Tyr Thr Leu His Tyr Lys Thr Asp Ala Pro
                325                 330                 335     
Leu Asn Ile Arg Ser Ile Phe Tyr Val Pro Asp Met Lys Pro Ser Met
            340                 345                 350         
Phe Asp Val Ser Arg Glu Leu Gly Ser Ser Val Ala Leu Tyr Ser Arg
        355                 360                 365             
Lys Val Leu Ile Gln Thr Lys Ala Thr Asp Ile Leu Pro Lys Trp Leu
    370                 375                 380                 
Arg Phe Ile Arg Gly Val Val Asp Ser Glu Asp Ile Pro Leu Asn Leu
385                 390                 395                 400 
Ser Arg Glu Leu Leu Gln Glu Ser Ala Leu Ile Arg Lys Leu Arg Asp
                405                 410                 415     
Val Leu Gln Gln Arg Leu Ile Lys Phe Phe Ile Asp Gln Ser Lys Lys
            420                 425                 430         
Asp Ala Glu Lys Tyr Ala Lys Phe Phe Glu Asp Tyr Gly Leu Phe Met
        435                 440                 445             
Arg Glu Gly Ile Val Thr Ala Thr Glu Gln Glu Val Lys Glu Asp Ile
    450                 455                 460                 
Ala Lys Leu Leu Arg Tyr Glu Ser Ser Ala Leu Pro Ser Gly Gln Leu
465                 470                 475                 480 
Thr Ser Leu Ser Glu Tyr Ala Ser Arg Met Arg Ala Gly Thr Arg Asn
                485                 490                 495     
Ile Tyr Tyr Leu Cys Ala Pro Asn Arg His Leu Ala Glu His Ser Pro
            500                 505                 510         
Tyr Tyr Glu Ala Met Lys Lys Lys Asp Thr Glu Val Leu Phe Cys Phe
        515                 520                 525             
Glu Gln Phe Asp Glu Leu Thr Leu Leu His Leu Arg Glu Phe Asp Lys
    530                 535                 540                 
Lys Lys Leu Ile Ser Val Glu Thr Asp Ile Val Val Asp His Tyr Lys
545                 550                 555                 560 
Glu Glu Lys Phe Glu Asp Arg Ser Pro Ala Ala Glu Cys Leu Ser Glu
                565                 570                 575     
Lys Glu Thr Glu Glu Leu Met Ala Trp Met Arg Asn Val Leu Gly Ser
            580                 585                 590         
Arg Val Thr Asn Val Lys Val Thr Leu Arg Leu Asp Thr His Pro Ala
        595                 600                 605             
Met Val Thr Val Leu Glu Met Gly Ala Ala Arg His Phe Leu Arg Met
    610                 615                 620                 
Gln Gln Leu Ala Lys Thr Gln Glu Glu Arg Ala Gln Leu Leu Gln Pro
625                 630                 635                 640 
Thr Leu Glu Ile Asn Pro Arg His Ala Leu Ile Lys Lys Leu Asn Gln
                645                 650                 655     
Leu Arg Ala Ser Glu Pro Gly Leu Ala Gln Leu Leu Val Asp Gln Ile
            660                 665                 670         
Tyr Glu Asn Ala Met Ile Ala Ala Gly Leu Val Asp Asp Pro Arg Ala
        675                 680                 685             
Met Val Gly Arg Leu Asn Glu Leu Leu Val Lys Ala Leu Glu Arg His
    690                 695                 700                 


<210> 2673
<211> 559
<212> PRT
<213> Homo sapiens

<400> 2673
Met Pro Leu Val Lys Arg Asn Ile Asp Pro Arg His Leu Cys His Thr
 1               5                  10                  15      
Ala Leu Pro Arg Gly Ile Lys Asn Glu Leu Glu Cys Val Thr Asn Ile
            20                  25                  30          
Ser Leu Ala Asn Ile Ile Arg Gln Leu Ser Ser Leu Ser Lys Tyr Ala
        35                  40                  45              
Glu Asp Ile Phe Gly Glu Leu Phe Asn Glu Ala His Ser Phe Ser Phe
    50                  55                  60                  
Arg Val Asn Ser Leu Gln Glu Arg Val Asp Arg Leu Ser Val Ser Val
65                  70                  75                  80  
Thr Gln Leu Asp Pro Lys Glu Glu Glu Leu Ser Leu Gln Asp Ile Thr
                85                  90                  95      
Met Arg Lys Ala Phe Arg Ser Ser Thr Ile Gln Asp Gln Gln Leu Phe
            100                 105                 110         
Asp Arg Lys Thr Leu Pro Ile Pro Leu Gln Glu Thr Tyr Asp Val Cys
        115                 120                 125             
Glu Gln Pro Pro Pro Leu Asn Ile Leu Thr Pro Tyr Arg Asp Asp Gly
    130                 135                 140                 
Lys Glu Gly Leu Lys Phe Tyr Thr Asn Pro Ser Tyr Phe Phe Asp Leu
145                 150                 155                 160 
Trp Lys Glu Lys Met Leu Gln Asp Thr Glu Asp Lys Arg Lys Glu Lys
                165                 170                 175     
Arg Lys Gln Lys Gln Lys Asn Leu Asp Arg Pro His Glu Pro Glu Lys
            180                 185                 190         
Val Pro Arg Ala Pro His Asp Arg Arg Arg Glu Trp Gln Lys Leu Ala
        195                 200                 205             
Gln Gly Pro Glu Leu Ala Glu Asp Asp Ala Asn Leu Leu His Lys His
    210                 215                 220                 
Ile Glu Val Ala Asn Gly Pro Ala Ser His Phe Glu Thr Arg Pro Gln
225                 230                 235                 240 
Thr Tyr Val Asp His Met Asp Gly Ser Tyr Ser Leu Ser Ala Leu Pro
                245                 250                 255     
Phe Ser Gln Met Ser Glu Leu Leu Thr Arg Ala Glu Glu Arg Val Leu
            260                 265                 270         
Val Arg Pro His Glu Pro Pro Pro Pro Pro Pro Met His Gly Ala Gly
        275                 280                 285             
Asp Ala Lys Pro Ile Pro Thr Cys Ile Ser Ser Ala Thr Gly Leu Ile
    290                 295                 300                 
Glu Asn Arg Pro Gln Ser Pro Ala Thr Gly Arg Thr Pro Val Phe Val
305                 310                 315                 320 
Ser Pro Thr Pro Pro Pro Pro Pro Pro Pro Leu Pro Ser Ala Leu Ser
                325                 330                 335     
Thr Ser Ser Leu Arg Ala Ser Met Thr Ser Thr Pro Pro Pro Pro Val
            340                 345                 350         
Pro Pro Pro Pro Pro Pro Pro Ala Thr Ala Leu Gln Ala Pro Ala Val
        355                 360                 365             
Pro Pro Pro Pro Ala Pro Pro Gln Ile Ala Pro Gly Val Leu His Pro
    370                 375                 380                 
Ala Pro Pro Pro Ile Ala Pro Pro Leu Val Gln Pro Ser Pro Pro Val
385                 390                 395                 400 
Ala Arg Ala Ala Pro Val Cys Glu Thr Val Pro Val His Pro Leu Pro
                405                 410                 415     
Gln Gly Glu Val Gln Gly Leu Pro Pro Pro Pro Pro Pro Pro Pro Leu
            420                 425                 430         
Pro Pro Pro Gly Ile Arg Pro Ser Ser Pro Val Thr Val Thr Ala Leu
        435                 440                 445             
Ala His Pro Pro Ser Gly Leu His Pro Thr Pro Ser Thr Ala Pro Gly
    450                 455                 460                 
Pro His Val Pro Leu Met Pro Pro Ser Pro Pro Ser Gln Val Ile Pro
465                 470                 475                 480 
Ala Ser Glu Pro Lys Arg His Pro Ser Thr Leu Pro Val Ile Ser Asp
                485                 490                 495     
Ala Arg Ser Val Leu Leu Glu Ala Ile Arg Lys Gly Ile Gln Leu Arg
            500                 505                 510         
Lys Val Glu Glu Gln Arg Glu Gln Glu Ala Lys His Glu Arg Ile Glu
        515                 520                 525             
Asn Asp Val Ala Thr Ile Leu Ser Arg Arg Ile Ala Val Glu Tyr Ser
    530                 535                 540                 
Asp Ser Glu Asp Asp Ser Glu Phe Asp Glu Val Asp Trp Leu Glu
545                 550                 555                 


<210> 2674
<211> 128
<212> PRT
<213> Homo sapiens

<400> 2674
His Glu Ala Gly Phe Gly Arg Arg Pro Arg Arg Pro Val Asp Gly Arg
 1               5                  10                  15      
Val Gly Arg Gly Thr Gly Pro Thr Ala Ala Val Ser Arg Phe Cys Pro
            20                  25                  30          
Arg Arg Val Arg Ala Met Ala Ala Ser Pro Gly Ser Gly Ser Ala Asn
        35                  40                  45              
Pro Arg Lys Phe Ser Glu Lys Ile Ala Leu His Thr Gln Arg Gln Ala
    50                  55                  60                  
Glu Glu Thr Arg Ala Phe Glu Gln Leu Met Thr Asp Leu Thr Leu Ser
65                  70                  75                  80  
Arg Val Gln Phe Gln Lys Leu Gln Gln Leu Arg Leu Thr Gln Tyr His
                85                  90                  95      
Gly Gly Ser Leu Pro Asn Val Ser Gln Leu Arg Ser Ser Ala Ser Glu
            100                 105                 110         
Phe Gln Val Glu Arg Asn Ser Ser Pro Cys Val Asp Gly Leu Arg Gln
        115                 120                 125             


<210> 2675
<211> 1036
<212> PRT
<213> Homo sapiens

<400> 2675
Met Ala Leu Arg Gly Ala Ala Gly Ala Thr Asp Thr Pro Val Ser Ser
 1               5                  10                  15      
Ala Gly Gly Ala Pro Gly Gly Ser Ala Ser Ser Ser Ser Thr Ser Ser
            20                  25                  30          
Gly Gly Ser Ala Ser Ala Gly Ala Gly Leu Trp Ala Ala Leu Tyr Asp
        35                  40                  45              
Tyr Glu Ala Arg Gly Glu Asp Glu Leu Ser Leu Arg Arg Gly Gln Leu
    50                  55                  60                  
Val Glu Val Leu Ser Gln Asp Ala Ala Val Ser Gly Asp Glu Gly Trp
65                  70                  75                  80  
Trp Ala Gly Gln Val Gln Arg Arg Leu Gly Ile Phe Pro Ala Asn Tyr
                85                  90                  95      
Val Ala Pro Cys Arg Pro Ala Ala Ser Pro Ala Pro Pro Pro Ser Arg
            100                 105                 110         
Pro Ser Ser Pro Val His Val Ala Phe Glu Arg Leu Glu Leu Lys Glu
        115                 120                 125             
Leu Ile Gly Ala Gly Gly Phe Gly Gln Val Tyr Arg Ala Thr Trp Gln
    130                 135                 140                 
Gly Gln Glu Val Ala Val Lys Ala Ala Arg Gln Asp Pro Glu Gln Asp
145                 150                 155                 160 
Ala Ala Ala Ala Ala Glu Ser Val Arg Arg Glu Ala Arg Leu Phe Ala
                165                 170                 175     
Met Leu Arg His Pro Asn Ile Ile Glu Leu Arg Gly Val Cys Leu Gln
            180                 185                 190         
Gln Pro His Leu Cys Leu Val Leu Glu Phe Ala Arg Gly Gly Ala Leu
        195                 200                 205             
Asn Arg Ala Leu Ala Ala Ala Asn Ala Ala Pro Asp Pro Arg Ala Pro
    210                 215                 220                 
Gly Pro Arg Arg Ala Arg Arg Ile Pro Pro His Val Leu Val Asn Trp
225                 230                 235                 240 
Ala Val Gln Ile Ala Arg Gly Met Leu Tyr Leu His Glu Glu Ala Phe
                245                 250                 255     
Val Pro Ile Leu His Arg Asp Leu Lys Ser Ser Asn Ile Leu Leu Leu
            260                 265                 270         
Glu Glu Ile Glu His Asp Asp Ile Cys Asn Lys Thr Leu Lys Ile Thr
        275                 280                 285             
Asp Phe Gly Leu Ala Arg Glu Trp His Arg Thr Thr Lys Met Ser Thr
    290                 295                 300                 
Ala Gly Thr Tyr Ala Trp Met Ala Pro Glu Val Ile Lys Ser Ser Leu
305                 310                 315                 320 
Phe Ser Lys Gly Ser Asp Ile Trp Ser Cys Gly Val Leu Leu Trp Glu
                325                 330                 335     
Leu Leu Thr Gly Glu Val Pro Tyr Arg Gly Ile Asp Gly Leu Ala Val
            340                 345                 350         
Ala Tyr Gly Val Ala Val Asn Lys Leu Thr Leu Pro Ile Pro Ser Thr
        355                 360                 365             
Cys Pro Glu Pro Phe Ala Lys Leu Met Lys Glu Cys Trp Gln Gln Asp
    370                 375                 380                 
Pro His Ile Arg Pro Ser Phe Ala Leu Ile Leu Glu Gln Leu Thr Ala
385                 390                 395                 400 
Ile Glu Gly Ala Val Met Thr Glu Met Pro Gln Glu Ser Phe His Ser
                405                 410                 415     
Met Gln Asp Asp Trp Lys Leu Glu Ile Gln Gln Met Phe Asp Glu Leu
            420                 425                 430         
Arg Thr Lys Glu Lys Glu Leu Arg Ser Arg Glu Glu Glu Leu Thr Arg
        435                 440                 445             
Ala Ala Leu Gln Gln Lys Ser Gln Glu Glu Leu Leu Lys Arg Arg Glu
    450                 455                 460                 
Gln Gln Leu Ala Glu Arg Glu Ile Asp Val Leu Glu Arg Glu Leu Asn
465                 470                 475                 480 
Ile Leu Ile Phe Gln Leu Asn Gln Glu Lys Pro Lys Val Lys Lys Arg
                485                 490                 495     
Lys Gly Lys Phe Lys Arg Ser Arg Leu Lys Leu Lys Asp Gly His Arg
            500                 505                 510         
Ile Ser Leu Pro Ser Asp Phe Gln His Lys Ile Thr Val Gln Ala Ser
        515                 520                 525             
Pro Asn Leu Asp Lys Arg Arg Ser Leu Asn Ser Ser Ser Ser Ser Pro
    530                 535                 540                 
Pro Ser Ser Pro Thr Met Met Pro Arg Leu Arg Ala Ile Gln Leu Thr
545                 550                 555                 560 
Ser Asp Glu Ser Asn Lys Thr Trp Gly Arg Asn Thr Val Phe Arg Gln
                565                 570                 575     
Glu Glu Phe Glu Asp Val Lys Arg Asn Phe Lys Lys Lys Gly Cys Thr
            580                 585                 590         
Trp Gly Pro Asn Ser Ile Gln Met Lys Asp Arg Thr Asp Cys Lys Glu
        595                 600                 605             
Arg Ile Arg Pro Leu Ser Asp Gly Asn Ser Pro Trp Ser Thr Ile Leu
    610                 615                 620                 
Ile Lys Asn Gln Lys Thr Met Pro Leu Ala Ser Leu Phe Val Asp Gln
625                 630                 635                 640 
Pro Gly Ser Cys Glu Glu Pro Lys Leu Ser Pro Asp Gly Leu Glu His
                645                 650                 655     
Arg Lys Pro Lys Gln Ile Lys Leu Pro Ser Gln Ala Tyr Ile Asp Leu
            660                 665                 670         
Pro Leu Gly Lys Asp Ala Gln Arg Glu Asn Pro Ala Glu Ala Gly Ser
        675                 680                 685             
Trp Glu Glu Ala Ala Ser Ala Asn Ala Ala Thr Val Thr Ile Glu Met
    690                 695                 700                 
Ala Pro Thr Asn Ser Leu Ser Arg Ser Pro Gln Arg Lys Lys Thr Glu
705                 710                 715                 720 
Ser Ala Leu Tyr Gly Cys Thr Val Leu Leu Ala Ser Val Ala Leu Gly
                725                 730                 735     
Leu Asp Leu Arg Glu Leu His Lys Ala Gln Ala Ala Glu Glu Pro Leu
            740                 745                 750         
Pro Lys Glu Glu Lys Lys Lys Arg Glu Gly Ile Phe Gln Arg Ala Ser
        755                 760                 765             
Lys Ser Arg Arg Ser Ala Ser Pro Pro Thr Ser Leu Ser Ser Thr Cys
    770                 775                 780                 
Gly Glu Ala Ser Ser Pro Pro Ser Leu Pro Leu Ser Ser Ala Leu Gly
785                 790                 795                 800 
Ile Leu Ser Thr Pro Ser Phe Ser Thr Lys Cys Leu Leu Gln Met Asp
                805                 810                 815     
Ser Glu Asp Pro Leu Val Asp Ser Ala Pro Val Thr Cys Asp Ser Glu
            820                 825                 830         
Met Leu Thr Pro Asp Phe Cys Pro Thr Ala Pro Gly Ser Gly Arg Glu
        835                 840                 845             
Pro Ala Leu Met Pro Arg Leu Asp Thr Asp Cys Ser Val Ser Arg Asn
    850                 855                 860                 
Leu Pro Ser Ser Phe Leu Gln Arg Thr Cys Gly Asn Val Pro Tyr Cys
865                 870                 875                 880 
Ala Ser Ser Lys His Arg Pro Ser His His Arg Arg Thr Met Ser Asp
                885                 890                 895     
Gly Asn Pro Thr Pro Thr Gly Ala Thr Ile Ile Ser Ala Thr Gly Ala
            900                 905                 910         
Ser Ala Leu Pro Leu Cys Pro Ser Pro Ala Pro His Ser His Leu Pro
        915                 920                 925             
Arg Glu Val Ser Pro Lys Lys His Ser Thr Val His Ile Val Pro Gln
    930                 935                 940                 
Arg Arg Pro Ala Ser Leu Arg Ser Arg Ser Asp Leu Pro Gln Ala Tyr
945                 950                 955                 960 
Pro Gln Thr Ala Val Ser Gln Leu Ala Gln Thr Ala Cys Val Val Gly
                965                 970                 975     
Arg Pro Gly Pro His Pro Thr Gln Phe Leu Ala Ala Lys Glu Arg Thr
            980                 985                 990         
Lys Ser His Val Pro Ser Leu Leu Asp Val Asp Val Glu Gly Gln Ser
        995                 1000                1005            
Arg Asp Tyr Thr Val Pro Leu Gly Arg Met Arg Ser Lys Thr Ser Arg
    1010                1015                1020                
Pro Ser Ile Tyr Glu Leu Glu Lys Glu Phe Leu Ser
1025                1030                1035    


<210> 2676
<211> 314
<212> PRT
<213> Homo sapiens

<400> 2676
Thr Ser Thr Ser Arg Ser Ser Glu Arg Thr Pro Gly Ala Ala Thr Ala
 1               5                  10                  15      
Ser Ala Ser Gly Ala Ala Glu Asp Gly Ala Cys Gly Cys Leu Pro Asn
            20                  25                  30          
Pro Gly Thr Phe Glu Glu Cys His Arg Lys Cys Lys Glu Leu Phe Pro
        35                  40                  45              
Ile Gln Met Glu Gly Val Lys Leu Thr Val Asn Lys Gly Leu Ser Asn
    50                  55                  60                  
His Phe Gln Val Asn His Thr Val Ala Leu Ser Thr Ile Gly Glu Ser
65                  70                  75                  80  
Asn Tyr His Phe Gly Val Thr Tyr Val Gly Thr Lys Gln Leu Ser Pro
                85                  90                  95      
Thr Glu Ala Phe Pro Val Leu Val Gly Asp Met Asp Asn Ser Gly Ser
            100                 105                 110         
Leu Asn Ala Gln Val Ile His Gln Leu Gly Pro Gly Leu Arg Ser Lys
        115                 120                 125             
Met Ala Ile Gln Thr Gln Gln Ser Lys Phe Val Asn Trp Gln Val Asp
    130                 135                 140                 
Gly Glu Tyr Arg Gly Ser Asp Phe Thr Ala Ala Val Thr Leu Gly Asn
145                 150                 155                 160 
Pro Asp Val Leu Val Gly Ser Gly Ile Leu Val Ala His Tyr Leu Gln
                165                 170                 175     
Ser Ile Thr Pro Cys Leu Ala Leu Gly Gly Glu Leu Val Tyr His Arg
            180                 185                 190         
Arg Pro Gly Glu Glu Gly Thr Val Met Ser Leu Ala Gly Lys Tyr Thr
        195                 200                 205             
Leu Asn Ser Trp Leu Ala Thr Val Thr Leu Gly Gln Ala Gly Met His
    210                 215                 220                 
Ala Thr Tyr Tyr His Lys Ala Ser Asp Gln Leu Gln Val Gly Val Glu
225                 230                 235                 240 
Phe Glu Ala Ser Thr Arg Met Gln Asp Ala Ser Val Ser Phe Gly Tyr
                245                 250                 255     
Gln Leu Asp Leu Pro Lys Ala Asn Leu Leu Phe Lys Gly Ser Val Asp
            260                 265                 270         
Ser Asn Trp Ile Val Gly Ala Thr Leu Glu Lys Lys Leu Pro Pro Leu
        275                 280                 285             
Pro Leu Thr Leu Ala Leu Gly Ala Phe Leu Asn His Arg Lys Asn Lys
    290                 295                 300                 
Phe Gln Cys Gly Phe Gly Leu Thr Ile Gly
305                 310                 


<210> 2677
<211> 267
<212> PRT
<213> Homo sapiens

<400> 2677
Met Ala Ala Pro Val Val Thr Ala Pro Gly Arg Ala Leu Leu Arg Ala
 1               5                  10                  15      
Gly Ala Gly Arg Leu Leu Arg Gly Gly Val Gln Glu Leu Leu Arg Pro
            20                  25                  30          
Arg His Glu Gly Asn Ala Pro Asp Leu Ala Cys Asn Phe Ser Leu Ser
        35                  40                  45              
Gln Asn Arg Gly Thr Val Ile Val Glu Arg Trp Trp Lys Val Pro Leu
    50                  55                  60                  
Ala Gly Glu Gly Arg Lys Pro Arg Leu His Arg Arg His Arg Val Tyr
65                  70                  75                  80  
Lys Leu Val Glu Asp Thr Lys His Arg Pro Lys Glu Asn Leu Glu Leu
                85                  90                  95      
Ile Leu Thr Gln Ser Val Glu Asn Val Gly Val Arg Gly Asp Leu Val
            100                 105                 110         
Ser Val Lys Lys Ser Leu Gly Arg Asn Arg Leu Leu Pro Gln Gly Leu
        115                 120                 125             
Ala Val Tyr Ala Ser Pro Glu Asn Lys Lys Leu Phe Glu Glu Glu Lys
    130                 135                 140                 
Leu Leu Arg Gln Glu Gly Lys Leu Glu Lys Ile Gln Thr Lys Ala Gly
145                 150                 155                 160 
Glu Ala Thr Val Lys Phe Leu Lys Ser Cys Arg Leu Glu Val Gly Met
                165                 170                 175     
Lys Asn Asn Val Lys Trp Glu Leu Asn Pro Glu Ile Val Ala Arg His
            180                 185                 190         
Phe Phe Lys Asn Leu Gly Val Val Val Ala Pro His Thr Leu Lys Leu
        195                 200                 205             
Pro Ala Glu Pro Ile Thr Arg Trp Gly Glu Tyr Trp Cys Glu Val Thr
    210                 215                 220                 
Val Asn Gly Leu Asp Thr Val Arg Val Pro Met Ser Val Val Asn Phe
225                 230                 235                 240 
Glu Lys Pro Lys Thr Lys Arg Tyr Lys Tyr Trp Leu Ala Gln Gln Ala
                245                 250                 255     
Ala Lys Ala Met Ala Pro Thr Ser Pro Gln Ile
            260                 265         


<210> 2678
<211> 267
<212> PRT
<213> Homo sapiens

<400> 2678
Met Glu Gly Asp Cys Leu Ser Cys Met Lys Tyr Leu Met Phe Val Phe
 1               5                  10                  15      
Asn Phe Phe Ile Phe Leu Gly Gly Ala Cys Leu Leu Ala Ile Gly Ile
            20                  25                  30          
Trp Val Met Val Asp Pro Thr Gly Phe Arg Glu Ile Val Ala Ala Asn
        35                  40                  45              
Pro Leu Leu Leu Thr Gly Ala Tyr Ile Leu Leu Ala Met Gly Gly Leu
    50                  55                  60                  
Leu Phe Leu Leu Gly Phe Leu Gly Cys Cys Gly Ala Val Arg Glu Asn
65                  70                  75                  80  
Lys Cys Leu Leu Leu Phe Phe Phe Leu Phe Ile Leu Ile Ile Phe Leu
                85                  90                  95      
Ala Glu Leu Ser Ala Ala Ile Leu Ala Phe Ile Phe Arg Glu Asn Leu
            100                 105                 110         
Thr Arg Glu Phe Phe Thr Lys Glu Leu Thr Lys His Tyr Gln Gly Asn
        115                 120                 125             
Asn Asp Thr Asp Val Phe Ser Ala Thr Trp Asn Ser Val Met Ile Thr
    130                 135                 140                 
Phe Gly Cys Cys Gly Val Asn Gly Pro Glu Asp Phe Lys Phe Ala Ser
145                 150                 155                 160 
Val Phe Arg Leu Leu Thr Leu Asp Ser Glu Glu Val Pro Glu Ala Cys
                165                 170                 175     
Cys Arg Arg Glu Pro Gln Ser Arg Asp Gly Val Leu Leu Ser Arg Glu
            180                 185                 190         
Glu Cys Leu Leu Gly Arg Ser Leu Phe Leu Asn Lys Gln Gly Cys Tyr
        195                 200                 205             
Thr Val Ile Leu Asn Thr Phe Glu Thr Tyr Val Tyr Leu Ala Gly Ala
    210                 215                 220                 
Leu Ala Ile Gly Val Leu Ala Ile Glu Glu Glu Arg Ala His Ser Val
225                 230                 235                 240 
Ser Gln Ala Thr Gly Ile Leu Tyr Gln Leu Pro Ala Ser Pro Gln Ala
                245                 250                 255     
Phe Gln Ser Pro Gly Thr Leu Gly Ala Thr Ala
            260                 265         


<210> 2679
<211> 540
<212> PRT
<213> Homo sapiens

<400> 2679
Met Gly Ser His Ala Val Val Asn Leu Ile Asn Tyr Gln Asp Asp Ala
 1               5                  10                  15      
Glu Leu Ala Thr Arg Ala Ile Pro Glu Leu Thr Lys Leu Leu Asn Asp
            20                  25                  30          
Glu Asp Gln Val Val Val Asn Lys Ala Ala Val Met Val His Gln Leu
        35                  40                  45              
Ser Lys Lys Glu Ala Ser Arg His Ala Ile Met Arg Ser Pro Gln Met
    50                  55                  60                  
Val Ser Ala Ile Val Arg Thr Met Gln Asn Thr Asn Asp Val Glu Thr
65                  70                  75                  80  
Ala Arg Cys Thr Ala Gly Thr Leu His Asn Leu Ser His His Arg Glu
                85                  90                  95      
Gly Leu Leu Ala Ile Phe Lys Ser Gly Gly Ile Pro Ala Leu Val Lys
            100                 105                 110         
Met Leu Gly Ser Pro Val Asp Ser Val Leu Phe Tyr Ala Ile Thr Thr
        115                 120                 125             
Leu His Asn Leu Leu Leu His Gln Glu Gly Ala Lys Met Ala Val Arg
    130                 135                 140                 
Leu Ala Gly Gly Leu Gln Lys Met Val Ala Leu Leu Asn Lys Thr Asn
145                 150                 155                 160 
Val Lys Phe Leu Ala Ile Thr Thr Asp Cys Leu Gln Ile Leu Ala Tyr
                165                 170                 175     
Gly Asn Gln Glu Ser Lys Leu Ile Ile Leu Ala Ser Gly Gly Pro Gln
            180                 185                 190         
Ala Leu Val Asn Ile Met Arg Thr Tyr Thr Tyr Glu Lys Leu Leu Trp
        195                 200                 205             
Thr Thr Ser Arg Val Leu Lys Val Leu Ser Val Cys Ser Ser Asn Lys
    210                 215                 220                 
Pro Ala Ile Val Glu Ala Gly Gly Met Gln Ala Leu Gly Leu His Leu
225                 230                 235                 240 
Thr Asp Pro Ser Gln Arg Leu Val Gln Asn Cys Leu Trp Thr Leu Arg
                245                 250                 255     
Asn Leu Ser Asp Ala Ala Thr Lys Gln Glu Gly Met Glu Gly Leu Leu
            260                 265                 270         
Gly Thr Leu Val Gln Leu Leu Gly Ser Asp Asp Ile Asn Val Val Thr
        275                 280                 285             
Cys Ala Ala Gly Ile Leu Ser Asn Leu Thr Cys Asn Asn Tyr Lys Asn
    290                 295                 300                 
Lys Met Met Val Cys Gln Val Gly Gly Ile Glu Ala Leu Val Arg Thr
305                 310                 315                 320 
Val Leu Arg Ala Gly Asp Arg Glu Asp Ile Thr Glu Pro Ala Ile Cys
                325                 330                 335     
Ala Leu Arg His Leu Thr Ser Arg His Gln Glu Ala Glu Met Ala Gln
            340                 345                 350         
Asn Ala Val Arg Leu His Tyr Gly Leu Pro Val Val Val Lys Leu Leu
        355                 360                 365             
His Pro Pro Ser His Trp Pro Leu Ile Lys Ala Thr Val Gly Leu Ile
    370                 375                 380                 
Arg Asn Leu Ala Leu Cys Pro Ala Asn His Ala Pro Leu Arg Glu Gln
385                 390                 395                 400 
Gly Ala Ile Pro Arg Leu Val Gln Leu Leu Val Arg Ala His Gln Asp
                405                 410                 415     
Thr Gln Arg Arg Thr Ser Met Gly Gly Thr Gln Gln Gln Phe Val Glu
            420                 425                 430         
Gly Val Arg Met Glu Glu Ile Val Glu Gly Cys Thr Gly Ala Leu His
        435                 440                 445             
Ile Leu Ala Arg Asp Val His Asn Arg Ile Val Ile Arg Gly Leu Asn
    450                 455                 460                 
Thr Ile Pro Leu Phe Val Gln Leu Leu Tyr Ser Pro Ile Glu Asn Ile
465                 470                 475                 480 
Gln Arg Val Ala Ala Gly Val Leu Cys Glu Leu Ala Gln Asp Lys Glu
                485                 490                 495     
Ala Ala Glu Ala Ile Glu Ala Glu Gly Ala Thr Ala Pro Leu Thr Glu
            500                 505                 510         
Leu Leu His Ser Arg Asn Glu Gly Val Ala Thr Tyr Ala Ala Ala Val
        515                 520                 525             
Leu Phe Arg Met Ser Glu Asp Lys Pro Gln Asp Tyr
    530                 535                 540 


<210> 2680
<211> 272
<212> PRT
<213> Homo sapiens

<400> 2680
Ser Ser Glu Met Lys Thr Glu Asp Glu Leu Arg Val Arg His Leu Glu
 1               5                  10                  15      
Glu Glu Asn Arg Gly Ile Val Val Leu Gly Ile Asn Arg Ala Tyr Gly
            20                  25                  30          
Lys Asn Ser Leu Ser Lys Asn Leu Ile Lys Met Leu Ser Lys Ala Val
        35                  40                  45              
Asp Ala Leu Lys Ser Asp Lys Lys Val Arg Thr Ile Ile Ile Arg Ser
    50                  55                  60                  
Glu Val Pro Gly Ile Phe Cys Ala Gly Ala Asp Leu Lys Glu Arg Ala
65                  70                  75                  80  
Lys Met Ser Ser Ser Glu Val Gly Pro Phe Val Ser Lys Ile Arg Ala
                85                  90                  95      
Val Ile Asn Asp Ile Ala Asn Leu Pro Val Pro Thr Ile Ala Ala Ile
            100                 105                 110         
Asp Gly Leu Ala Leu Gly Gly Gly Leu Glu Leu Ala Leu Ala Cys Asp
        115                 120                 125             
Ile Arg Val Ala Ala Ser Ser Ala Lys Met Gly Leu Val Glu Thr Lys
    130                 135                 140                 
Leu Ala Ile Ile Pro Gly Gly Gly Gly Thr Gln Arg Leu Pro Arg Ala
145                 150                 155                 160 
Ile Gly Met Ser Leu Ala Lys Glu Leu Ile Phe Ser Ala Arg Val Leu
                165                 170                 175     
Asp Gly Lys Glu Ala Lys Ala Val Gly Leu Ile Ser His Val Leu Glu
            180                 185                 190         
Gln Asn Gln Glu Gly Asp Ala Ala Tyr Arg Lys Ala Leu Asp Leu Ala
        195                 200                 205             
Arg Glu Phe Leu Pro Gln Gly Pro Val Ala Met Arg Val Ala Lys Leu
    210                 215                 220                 
Ala Ile Asn Gln Gly Met Glu Val Asp Leu Val Thr Gly Leu Ala Ile
225                 230                 235                 240 
Glu Glu Ala Cys Tyr Ala Gln Thr Ile Pro Thr Lys Asp Arg Leu Glu
                245                 250                 255     
Gly Leu Leu Ala Phe Lys Glu Lys Arg Pro Pro Arg Tyr Lys Gly Glu
            260                 265                 270         


<210> 2681
<211> 603
<212> PRT
<213> Homo sapiens

<400> 2681
Met Thr Met His Thr Thr Met Thr Thr Leu Thr Leu Thr Ser Leu Ile
 1               5                  10                  15      
Pro Pro Ile Leu Thr Thr Leu Val Asn Pro Asn Lys Lys Asn Ser Tyr
            20                  25                  30          
Pro His Tyr Val Lys Ser Ile Val Ala Ser Thr Phe Ile Ile Ser Leu
        35                  40                  45              
Phe Pro Thr Thr Met Phe Met Cys Leu Asp Gln Glu Val Ile Ile Ser
    50                  55                  60                  
Asn Trp His Trp Ala Thr Thr Gln Thr Thr Gln Leu Ser Leu Ser Phe
65                  70                  75                  80  
Lys Leu Asp Tyr Phe Ser Met Met Phe Ile Pro Val Ala Leu Phe Val
                85                  90                  95      
Thr Trp Ser Ile Met Glu Phe Ser Leu Trp Tyr Met Asn Ser Asp Pro
            100                 105                 110         
Asn Ile Asn Gln Phe Phe Lys Tyr Leu Leu Ile Phe Leu Ile Thr Met
        115                 120                 125             
Leu Ile Leu Val Thr Ala Asn Asn Leu Phe Gln Leu Phe Ile Gly Trp
    130                 135                 140                 
Glu Gly Val Gly Ile Met Ser Phe Leu Leu Ile Ser Trp Trp Tyr Ala
145                 150                 155                 160 
Arg Ala Asp Ala Asn Thr Ala Ala Ile Gln Ala Val Leu Tyr Asn Arg
                165                 170                 175     
Ile Gly Asp Ile Gly Phe Ile Leu Ala Leu Ala Trp Phe Ile Leu His
            180                 185                 190         
Ser Asn Ser Trp Asp Pro Gln Gln Met Ala Leu Leu Asn Ala Asn Pro
        195                 200                 205             
Ser Leu Thr Pro Leu Leu Gly Leu Leu Leu Ala Ala Ala Gly Lys Ser
    210                 215                 220                 
Ala Gln Leu Gly Leu His Pro Trp Leu Pro Ser Ala Met Glu Gly Pro
225                 230                 235                 240 
Thr Pro Val Ser Ala Leu Leu His Ser Ser Thr Met Val Val Ala Gly
                245                 250                 255     
Ile Phe Leu Leu Ile Arg Phe His Pro Leu Ala Glu Asn Ser Pro Leu
            260                 265                 270         
Ile Gln Thr Leu Thr Leu Cys Leu Gly Ala Ile Thr Thr Leu Phe Ala
        275                 280                 285             
Ala Val Cys Ala Leu Thr Gln Asn Asp Ile Lys Lys Ile Val Ala Phe
    290                 295                 300                 
Ser Thr Ser Ser Gln Leu Gly Leu Met Met Val Thr Ile Gly Ile Asn
305                 310                 315                 320 
Gln Pro His Leu Ala Phe Leu His Ile Cys Thr His Ala Phe Phe Lys
                325                 330                 335     
Ala Met Leu Phe Met Cys Ser Gly Ser Ile Ile His Asn Leu Asn Asn
            340                 345                 350         
Glu Gln Asp Ile Arg Lys Met Gly Gly Leu Leu Lys Thr Met Pro Leu
        355                 360                 365             
Thr Ser Thr Ser Leu Thr Ile Gly Ser Leu Ala Leu Ala Gly Met Pro
    370                 375                 380                 
Phe Leu Thr Gly Phe Tyr Ser Lys Asp His Ile Ile Glu Thr Ala Asn
385                 390                 395                 400 
Met Ser Tyr Thr Asn Ala Trp Ala Leu Ser Ile Thr Leu Ile Ala Thr
                405                 410                 415     
Ser Leu Thr Ser Ala Tyr Ser Thr Arg Met Ile Leu Leu Thr Leu Thr
            420                 425                 430         
Gly Gln Pro Arg Phe Pro Thr Leu Thr Asn Ile Asn Glu Asn Asn Pro
        435                 440                 445             
Thr Leu Leu Asn Pro Ile Lys Arg Leu Ala Ala Gly Ser Leu Phe Ala
    450                 455                 460                 
Gly Phe Leu Ile Thr Asn Asn Ile Ser Pro Ala Ser Pro Phe Gln Thr
465                 470                 475                 480 
Thr Ile Pro Leu Tyr Leu Lys Leu Thr Ala Leu Ala Val Thr Phe Leu
                485                 490                 495     
Gly Leu Leu Thr Ala Leu Asp Leu Asn Tyr Leu Thr Asn Lys Leu Lys
            500                 505                 510         
Met Lys Ser Pro Leu Cys Thr Phe Tyr Phe Ser Asn Met Leu Gly Phe
        515                 520                 525             
Tyr Pro Ser Ile Thr His Arg Thr Ile Pro Tyr Leu Gly Leu Leu Thr
    530                 535                 540                 
Ser Gln Asn Leu Pro Leu Leu Leu Leu Asp Leu Thr Trp Leu Glu Lys
545                 550                 555                 560 
Leu Leu Pro Lys Thr Ile Ser Gln His Gln Ile Ser Thr Ser Ile Ile
                565                 570                 575     
Thr Ser Thr Gln Lys Gly Met Ile Lys Leu Tyr Phe Leu Ser Phe Phe
            580                 585                 590         
Phe Pro Leu Ile Leu Thr Leu Leu Leu Ile Thr
        595                 600             


<210> 2682
<211> 459
<212> PRT
<213> Homo sapiens

<400> 2682
Met Leu Lys Leu Ile Val Pro Thr Ile Met Leu Leu Pro Leu Thr Trp
 1               5                  10                  15      
Leu Ser Lys Lys His Met Ile Trp Ile Asn Thr Thr Thr His Ser Leu
            20                  25                  30          
Ile Ile Ser Ile Ile Pro Leu Leu Phe Phe Asn Gln Ile Asn Asn Asn
        35                  40                  45              
Leu Phe Ser Cys Ser Pro Thr Phe Ser Ser Asp Pro Leu Thr Thr Pro
    50                  55                  60                  
Leu Leu Met Leu Thr Thr Trp Leu Leu Pro Leu Thr Ile Met Ala Ser
65                  70                  75                  80  
Gln Arg His Leu Ser Ser Glu Pro Leu Ser Arg Lys Lys Leu Tyr Leu
                85                  90                  95      
Ser Met Leu Ile Ser Leu Gln Ile Ser Leu Ile Met Thr Phe Thr Ala
            100                 105                 110         
Thr Glu Leu Ile Met Phe Tyr Ile Phe Phe Glu Thr Thr Leu Ile Pro
        115                 120                 125             
Thr Leu Ala Ile Ile Thr Arg Trp Gly Asn Gln Pro Glu Arg Leu Asn
    130                 135                 140                 
Ala Gly Thr Tyr Phe Leu Phe Tyr Thr Leu Val Gly Ser Leu Pro Leu
145                 150                 155                 160 
Leu Ile Ala Leu Ile Tyr Thr His Asn Thr Leu Gly Ser Leu Asn Ile
                165                 170                 175     
Leu Leu Leu Thr Leu Thr Ala Gln Glu Leu Ser Asn Ser Trp Ala Asn
            180                 185                 190         
Asn Leu Met Trp Leu Ala Tyr Thr Met Ala Phe Met Val Lys Met Pro
        195                 200                 205             
Leu Tyr Gly Leu Tyr Leu Trp Leu Pro Lys Ala His Val Glu Ala Pro
    210                 215                 220                 
Ile Ala Gly Ser Met Val Leu Ala Ala Val Leu Leu Lys Leu Gly Gly
225                 230                 235                 240 
Tyr Gly Met Met Arg Leu Thr Leu Ile Leu Asn Pro Leu Thr Lys His
                245                 250                 255     
Met Ala Tyr Pro Phe Leu Val Leu Ser Leu Trp Gly Met Ile Met Thr
            260                 265                 270         
Ser Ser Ile Cys Leu Arg Gln Thr Asp Leu Lys Ser Leu Ile Ala Tyr
        275                 280                 285             
Ser Ser Ile Ser His Met Ala Leu Val Val Thr Ala Ile Leu Ile Gln
    290                 295                 300                 
Thr Pro Trp Ser Phe Thr Gly Ala Val Ile Leu Met Ile Ala His Gly
305                 310                 315                 320 
Leu Thr Ser Ser Leu Leu Phe Cys Leu Ala Asn Ser Asn Tyr Glu Arg
                325                 330                 335     
Thr His Ser Arg Ile Met Ile Leu Ser Gln Gly Leu Gln Thr Leu Leu
            340                 345                 350         
Pro Leu Met Ala Phe Trp Trp Leu Leu Ala Ser Leu Ala Asn Leu Ala
        355                 360                 365             
Leu Pro Pro Thr Ile Asn Leu Leu Gly Glu Leu Ser Val Leu Val Thr
    370                 375                 380                 
Thr Phe Ser Trp Ser Asn Ile Thr Leu Leu Leu Thr Gly Leu Asn Met
385                 390                 395                 400 
Leu Val Thr Ala Leu Tyr Ser Leu Tyr Met Phe Thr Thr Thr Gln Trp
                405                 410                 415     
Gly Ser Leu Thr His His Ile Asn Asn Met Lys Pro Ser Phe Thr Arg
            420                 425                 430         
Glu Asn Thr Leu Met Phe Met His Leu Ser Pro Ile Leu Leu Leu Ser
        435                 440                 445             
Leu Asn Pro Asp Ile Ile Thr Gly Phe Ser Ser
    450                 455                 


<210> 2683
<211> 216
<212> PRT
<213> Homo sapiens

<400> 2683
Ala Ala Val Pro Arg Thr Pro Pro Pro Arg Ser Pro Asn Pro Ser Pro
 1               5                  10                  15      
Glu Arg Pro Arg Ser Ala Leu Ala Ala Ala Ile Leu Ala Thr Thr Leu
            20                  25                  30          
Thr Gly Arg Thr Val Ala Ile Pro Gln Pro Arg Gln Arg Ser Arg Ser
        35                  40                  45              
Glu Ser Asp Val Ser Ser Val Glu Gln Asp Ser Phe Ile Glu Pro Tyr
    50                  55                  60                  
Ala Thr Thr Ser Gln Leu Arg Pro Arg Pro Asn Trp Gln Ser Glu Met
65                  70                  75                  80  
Gly Arg Arg Ser Ser Leu Pro Ser Phe Glu Thr Leu Asp Tyr Gly Asp
                85                  90                  95      
Glu Glu Asp Ile Glu Thr Gln Leu Ser Ser Ser Gly Lys Glu Leu Gly
            100                 105                 110         
Asp Val Ser Ala Arg Glu Asp Arg Gly Gly His Ser Asp Asp Leu Tyr
        115                 120                 125             
Ala Val Pro His Arg Asn Gln Val Pro Leu Leu His Glu Val Asn Ser
    130                 135                 140                 
Glu Asp Asp Glu Asn Ile Ser His Gln Asp Gly Phe Pro Gly Ser Pro
145                 150                 155                 160 
Pro Ala Pro Gln Trp Thr Gln Gln Lys Asp Gly Lys His Pro Val Leu
                165                 170                 175     
Asn Leu Lys Asp Glu Lys Pro Pro Leu Cys Glu Lys Pro Pro Pro Ser
            180                 185                 190         
Pro Gly Ile Cys Leu Leu Asn Tyr Ile Met Ile Glu Lys Leu Val Leu
        195                 200                 205             
Glu Asn Ile Gln Ile Asn Phe Ile
    210                 215     


<210> 2684
<211> 226
<212> PRT
<213> Homo sapiens

<400> 2684
Met Ala Leu Ser Asp Val Asp Val Lys Lys Gln Ile Lys His Met Met
 1               5                  10                  15      
Ala Phe Ile Glu Gln Glu Ala Asn Glu Lys Ala Glu Glu Ile Asp Ala
            20                  25                  30          
Lys Ala Glu Glu Glu Phe Asn Ile Glu Lys Gly Arg Leu Val Gln Thr
        35                  40                  45              
Gln Arg Leu Lys Ile Met Glu Tyr Tyr Glu Lys Lys Glu Lys Gln Ile
    50                  55                  60                  
Glu Gln Gln Lys Lys Ile Leu Met Ser Thr Met Arg Asn Gln Ala Arg
65                  70                  75                  80  
Leu Lys Val Leu Arg Ala Arg Asn Asp Leu Ile Ser Asp Leu Leu Ser
                85                  90                  95      
Glu Ala Lys Leu Arg Leu Ser Arg Ile Val Glu Asp Pro Glu Val Tyr
            100                 105                 110         
Gln Gly Leu Leu Asp Lys Leu Val Leu Gln Gly Leu Leu Arg Leu Leu
        115                 120                 125             
Glu Pro Val Met Ile Val Arg Cys Arg Pro Gln Asp Leu Leu Leu Val
    130                 135                 140                 
Glu Ala Ala Val Gln Lys Ala Ile Pro Glu Tyr Met Thr Ile Ser Gln
145                 150                 155                 160 
Lys His Val Glu Val Gln Ile Asp Lys Glu Ala Tyr Leu Ala Val Asn
                165                 170                 175     
Ala Ala Gly Gly Val Glu Val Tyr Ser Gly Asn Gln Arg Ile Lys Val
            180                 185                 190         
Ser Asn Thr Leu Glu Ser Arg Leu Asp Leu Ser Ala Lys Gln Lys Met
        195                 200                 205             
Pro Glu Ile Arg Met Ala Leu Phe Gly Ala Asn Thr Asn Arg Lys Phe
    210                 215                 220                 
Phe Ile
225     


<210> 2685
<211> 236
<212> PRT
<213> Homo sapiens

<400> 2685
Met Ala Ser Leu Asp Arg Val Lys Val Leu Val Leu Gly Asp Ser Gly
 1               5                  10                  15      
Val Gly Lys Ser Ser Leu Val His Leu Leu Cys Gln Asn Gln Val Leu
            20                  25                  30          
Gly Asn Pro Ser Trp Thr Val Gly Cys Ser Val Asp Val Arg Val His
        35                  40                  45              
Asp Tyr Lys Glu Gly Thr Pro Glu Glu Lys Thr Cys Tyr Ile Glu Leu
    50                  55                  60                  
Trp Asp Val Gly Gly Ser Val Gly Ser Ala Ser Ser Val Lys Ser Thr
65                  70                  75                  80  
Arg Ala Val Phe Tyr Asn Ser Val Asn Gly Ile Ile Phe Val His Asp
                85                  90                  95      
Leu Thr Asn Lys Lys Ser Ser Gln Asn Leu Arg Arg Trp Ser Leu Glu
            100                 105                 110         
Ala Leu Asn Arg Asp Leu Val Pro Thr Gly Val Leu Val Thr Asn Gly
        115                 120                 125             
Asp Tyr Asp Gln Glu Gln Phe Ala Asp Asn Gln Ile Pro Leu Leu Val
    130                 135                 140                 
Ile Gly Thr Lys Leu Asp Gln Ile His Glu Thr Lys Arg His Glu Val
145                 150                 155                 160 
Leu Thr Thr Thr Ala Phe Leu Ala Glu Asp Phe Asn Pro Glu Glu Ile
                165                 170                 175     
Asn Leu Asp Cys Thr Asn Pro Arg Tyr Leu Ala Ala Gly Ser Ser Asn
            180                 185                 190         
Ala Val Lys Leu Ser Arg Phe Phe Asp Lys Val Ile Glu Lys Arg Tyr
        195                 200                 205             
Phe Leu Arg Glu Gly Asn Gln Ile Pro Gly Phe Pro Asp Arg Lys Arg
    210                 215                 220                 
Phe Gly Ala Gly Thr Leu Lys Ser Leu His Tyr Asp
225                 230                 235     


<210> 2686
<211> 773
<212> PRT
<213> Homo sapiens

<400> 2686
Met Glu Thr Asp Glu Ser Pro Ser Pro Leu Pro Cys Gly Pro Ala Gly
 1               5                  10                  15      
Glu Ala Val Met Glu Ser Arg Ala Arg Pro Phe Gln Ala Leu Pro Arg
            20                  25                  30          
Glu Gln Ser Pro Pro Pro Pro Leu Gln Thr Ser Ser Gly Ala Glu Val
        35                  40                  45              
Met Asp Val Gly Ser Gly Gly Asp Gly Gln Ser Glu Leu Pro Ala Glu
    50                  55                  60                  
Asp Pro Phe Asn Phe Tyr Gly Ala Ser Leu Leu Ser Lys Gly Ser Phe
65                  70                  75                  80  
Ser Lys Gly Arg Leu Leu Ile Asp Pro Asn Cys Ser Gly His Ser Pro
                85                  90                  95      
Arg Thr Ala Arg His Ala Pro Ala Val Arg Lys Phe Ser Pro Asp Leu
            100                 105                 110         
Lys Leu Leu Lys Asp Val Lys Ile Ser Val Ser Phe Thr Glu Ser Cys
        115                 120                 125             
Arg Ser Lys Asp Arg Lys Val Leu Tyr Thr Gly Ala Glu Arg Asp Val
    130                 135                 140                 
Arg Ala Glu Cys Gly Leu Leu Leu Ser Pro Val Ser Gly Asp Val His
145                 150                 155                 160 
Ala Cys Pro Phe Gly Gly Ser Val Gly Asp Gly Val Gly Ile Gly Gly
                165                 170                 175     
Glu Ser Ala Asp Lys Lys Asp Glu Glu Asn Glu Leu Asp Gln Glu Lys
            180                 185                 190         
Arg Val Glu Tyr Ala Val Leu Asp Glu Leu Glu Asp Phe Thr Asp Asn
        195                 200                 205             
Leu Glu Leu Asp Glu Glu Gly Ala Gly Gly Phe Thr Ala Lys Ala Ile
    210                 215                 220                 
Val Gln Arg Asp Arg Val Asp Glu Glu Ala Leu Asn Phe Pro Tyr Glu
225                 230                 235                 240 
Asp Asp Phe Asp Asn Asp Val Asp Ala Leu Leu Glu Glu Gly Leu Cys
                245                 250                 255     
Ala Pro Lys Lys Arg Arg Thr Glu Glu Lys Tyr Gly Gly Asp Ser Asp
            260                 265                 270         
His Pro Ser Asp Gly Glu Thr Ser Val Gln Pro Met Met Thr Lys Ile
        275                 280                 285             
Lys Thr Val Leu Lys Ser Arg Gly Arg Pro Pro Thr Glu Pro Leu Pro
    290                 295                 300                 
Asp Gly Trp Ile Met Thr Phe His Asn Ser Gly Val Pro Val Tyr Leu
305                 310                 315                 320 
His Arg Glu Ser Arg Val Val Thr Trp Ser Arg Pro Tyr Phe Leu Gly
                325                 330                 335     
Thr Gly Ser Ile Arg Lys His Asp Pro Pro Leu Ser Ser Ile Pro Cys
            340                 345                 350         
Leu His Tyr Lys Lys Met Lys Asp Asn Glu Glu Arg Glu Gln Ser Ser
        355                 360                 365             
Asp Leu Thr Pro Ser Gly Asp Val Ser Pro Val Lys Pro Leu Ser Arg
    370                 375                 380                 
Ser Ala Glu Leu Glu Phe Pro Leu Asp Glu Pro Asp Ser Met Gly Ala
385                 390                 395                 400 
Asp Pro Gly Pro Pro Asp Glu Lys Asp Pro Leu Gly Ala Glu Ala Ala
                405                 410                 415     
Pro Gly Ala Leu Gly Gln Val Lys Ala Lys Val Glu Val Cys Lys Asp
            420                 425                 430         
Glu Ser Val Asp Leu Glu Glu Phe Arg Ser Tyr Leu Glu Lys Arg Phe
        435                 440                 445             
Asp Phe Glu Gln Val Thr Val Lys Lys Phe Arg Thr Trp Ala Glu Arg
    450                 455                 460                 
Arg Gln Phe Asn Arg Glu Met Lys Arg Lys Gln Ala Glu Ser Glu Arg
465                 470                 475                 480 
Pro Ile Leu Pro Ala Asn Gln Lys Leu Ile Thr Leu Ser Val Gln Asp
                485                 490                 495     
Ala Pro Thr Lys Lys Glu Phe Val Ile Asn Pro Asn Gly Lys Ser Glu
            500                 505                 510         
Val Cys Ile Leu His Glu Tyr Met Gln Arg Val Leu Lys Val Arg Pro
        515                 520                 525             
Val Tyr Asn Phe Phe Glu Cys Glu Asn Pro Ser Glu Pro Phe Gly Ala
    530                 535                 540                 
Ser Val Thr Ile Asp Gly Val Thr Tyr Gly Ser Gly Thr Ala Ser Ser
545                 550                 555                 560 
Lys Lys Leu Ala Lys Asn Lys Ala Ala Arg Ala Thr Leu Glu Ile Leu
                565                 570                 575     
Ile Pro Asp Phe Val Lys Gln Thr Ser Glu Glu Lys Pro Lys Asp Ser
            580                 585                 590         
Glu Glu Leu Glu Tyr Phe Asn His Ile Ser Ile Glu Asp Ser Arg Val
        595                 600                 605             
Tyr Glu Leu Thr Ser Lys Ala Gly Leu Leu Ser Pro Tyr Gln Ile Leu
    610                 615                 620                 
His Glu Cys Leu Lys Arg Asn His Gly Met Gly Asp Thr Ser Ile Lys
625                 630                 635                 640 
Phe Glu Val Val Pro Gly Lys Asn Gln Lys Ser Glu Tyr Val Met Ala
                645                 650                 655     
Cys Gly Lys His Thr Val Arg Gly Trp Cys Lys Asn Lys Arg Val Gly
            660                 665                 670         
Lys Gln Leu Ala Ser Gln Lys Ile Leu Gln Leu Leu His Pro His Val
        675                 680                 685             
Lys Asn Trp Gly Ser Leu Leu Arg Met Tyr Gly Arg Glu Ser Ser Lys
    690                 695                 700                 
Met Val Lys Gln Glu Thr Ser Asp Lys Ser Val Ile Glu Leu Gln Gln
705                 710                 715                 720 
Tyr Ala Lys Lys Asn Lys Pro Asn Leu His Ile Leu Ser Lys Leu Gln
                725                 730                 735     
Glu Glu Met Lys Arg Leu Ala Glu Glu Arg Glu Glu Thr Arg Lys Lys
            740                 745                 750         
Pro Lys Met Ser Ile Val Ala Ser Ala Gln Pro Gly Gly Glu Pro Leu
        755                 760                 765             
Cys Thr Val Asp Val
    770             


<210> 2687
<211> 5171
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 4471
<223> Xaa = Any Amino Acid

<400> 2687
Met His Ser Ser Ser Tyr Ser Tyr Arg Ser Ser Asp Ser Val Phe Ser
 1               5                  10                  15      
Asn Thr Thr Ser Thr Arg Thr Ser Leu Asp Ser Asn Glu Asn Leu Leu
            20                  25                  30          
Leu Val His Cys Gly Pro Thr Leu Ile Asn Ser Cys Ile Ser Phe Gly
        35                  40                  45              
Ser Glu Ser Phe Asp Gly His Arg Leu Glu Met Leu Gln Gln Ile Ala
    50                  55                  60                  
Asn Arg Val Gln Arg Asp Ser Val Ile Cys Glu Asp Lys Leu Ile Leu
65                  70                  75                  80  
Ala Gly Asn Ala Leu Gln Ser Asp Ser Lys Arg Leu Glu Ser Gly Val
                85                  90                  95      
Gln Phe Gln Asn Glu Ala Glu Ile Ala Gly Tyr Ile Leu Glu Cys Glu
            100                 105                 110         
Asn Leu Leu Arg Gln His Val Ile Asp Val Gln Ile Leu Ile Asp Gly
        115                 120                 125             
Lys Tyr Tyr Gln Ala Asp Gln Leu Val Gln Arg Val Ala Lys Leu Arg
    130                 135                 140                 
Asp Glu Ile Met Ala Leu Arg Asn Glu Cys Ser Ser Val Tyr Ser Lys
145                 150                 155                 160 
Gly Arg Ile Leu Thr Thr Glu Gln Thr Lys Leu Met Ile Ser Gly Ile
                165                 170                 175     
Thr Gln Ser Leu Asn Ser Gly Phe Ala Gln Thr Leu His Pro Ser Leu
            180                 185                 190         
Thr Ser Gly Leu Thr Gln Ser Leu Thr Pro Ser Leu Thr Ser Ser Ser
        195                 200                 205             
Met Thr Ser Gly Leu Ser Ser Gly Met Thr Ser Arg Leu Thr Pro Ser
    210                 215                 220                 
Val Thr Pro Ala Tyr Thr Pro Gly Phe Pro Ser Gly Leu Val Pro Asn
225                 230                 235                 240 
Phe Ser Ser Gly Val Glu Pro Asn Ser Leu Gln Thr Leu Lys Leu Met
                245                 250                 255     
Gln Ile Arg Lys Pro Leu Leu Lys Ser Ser Leu Leu Asp Gln Asn Leu
            260                 265                 270         
Thr Glu Glu Glu Ile Asn Met Lys Phe Val Gln Asp Leu Leu Asn Trp
        275                 280                 285             
Val Asp Glu Met Gln Val Gln Leu Asp Arg Thr Glu Trp Gly Ser Asp
    290                 295                 300                 
Leu Pro Ser Val Glu Ser His Leu Glu Asn His Lys Asn Val His Arg
305                 310                 315                 320 
Ala Ile Glu Glu Phe Glu Ser Ser Leu Lys Glu Ala Lys Ile Ser Glu
                325                 330                 335     
Ile Gln Met Thr Ala Pro Leu Lys Leu Thr Tyr Ala Glu Lys Leu His
            340                 345                 350         
Arg Leu Glu Ser Gln Tyr Ala Lys Leu Leu Asn Thr Ser Arg Asn Gln
        355                 360                 365             
Glu Arg His Leu Asp Thr Leu His Asn Phe Val Ser Arg Ala Thr Asn
    370                 375                 380                 
Glu Leu Ile Trp Leu Asn Glu Lys Glu Glu Glu Glu Val Ala Tyr Asp
385                 390                 395                 400 
Trp Ser Glu Arg Asn Thr Asn Ile Ala Arg Lys Lys Asp Tyr His Ala
                405                 410                 415     
Glu Leu Met Arg Glu Leu Asp Gln Lys Glu Glu Asn Ile Lys Ser Val
            420                 425                 430         
Gln Glu Ile Ala Glu Gln Leu Leu Leu Glu Asn His Pro Ala Arg Leu
        435                 440                 445             
Thr Ile Glu Ala Tyr Arg Ala Ala Met Gln Thr Gln Trp Ser Trp Ile
    450                 455                 460                 
Leu Gln Leu Cys Gln Cys Val Glu Gln His Ile Lys Glu Asn Thr Ala
465                 470                 475                 480 
Tyr Phe Glu Phe Phe Asn Asp Ala Lys Glu Ala Thr Asp Tyr Leu Arg
                485                 490                 495     
Asn Leu Lys Asp Ala Ile Gln Arg Lys Tyr Ser Cys Asp Arg Ser Ser
            500                 505                 510         
Ser Ile His Lys Leu Glu Asp Leu Val Gln Glu Ser Met Glu Glu Lys
        515                 520                 525             
Glu Glu Leu Leu Gln Tyr Lys Ser Thr Ile Ala Asn Leu Met Gly Lys
    530                 535                 540                 
Ala Lys Thr Ile Ile Gln Leu Lys Pro Arg Asn Ser Asp Cys Pro Leu
545                 550                 555                 560 
Lys Thr Ser Ile Pro Ile Lys Ala Ile Cys Asp Tyr Arg Gln Ile Glu
                565                 570                 575     
Ile Thr Ile Tyr Lys Asp Asp Glu Cys Val Leu Ala Asn Asn Ser His
            580                 585                 590         
Arg Ala Lys Trp Lys Val Ile Ser Pro Thr Gly Asn Glu Ala Met Val
        595                 600                 605             
Pro Ser Val Cys Phe Thr Val Pro Pro Pro Asn Lys Glu Ala Val Asp
    610                 615                 620                 
Leu Ala Asn Arg Ile Glu Gln Gln Tyr Gln Asn Val Leu Thr Leu Trp
625                 630                 635                 640 
His Glu Ser His Ile Asn Met Lys Ser Val Val Ser Trp His Tyr Leu
                645                 650                 655     
Ile Asn Glu Ile Asp Arg Ile Arg Ala Ser Asn Val Ala Ser Ile Lys
            660                 665                 670         
Thr Met Leu Pro Gly Glu His Gln Gln Val Leu Ser Asn Leu Gln Ser
        675                 680                 685             
Arg Phe Glu Asp Phe Leu Glu Asp Ser Gln Glu Ser Gln Val Phe Ser
    690                 695                 700                 
Gly Ser Asp Ile Thr Gln Leu Glu Lys Glu Val Asn Val Cys Lys Gln
705                 710                 715                 720 
Tyr Tyr Gln Glu Leu Leu Lys Ser Ala Glu Arg Glu Glu Gln Glu Glu
                725                 730                 735     
Ser Val Tyr Asn Leu Tyr Ile Ser Glu Val Arg Asn Ile Arg Leu Arg
            740                 745                 750         
Leu Glu Asn Cys Glu Asp Arg Leu Ile Arg Gln Ile Arg Thr Pro Leu
        755                 760                 765             
Glu Arg Asp Asp Leu His Glu Ser Val Phe Arg Ile Thr Glu Gln Glu
    770                 775                 780                 
Lys Leu Lys Lys Glu Leu Glu Arg Leu Lys Asp Asp Leu Gly Thr Ile
785                 790                 795                 800 
Thr Asn Lys Cys Glu Glu Phe Phe Ser Gln Ala Ala Ala Ser Ser Ser
                805                 810                 815     
Val Pro Thr Leu Arg Ser Glu Leu Asn Val Val Leu Gln Asn Met Asn
            820                 825                 830         
Gln Val Tyr Ser Met Ser Ser Thr Tyr Ile Asp Lys Leu Lys Thr Val
        835                 840                 845             
Asn Leu Gly Leu Lys Asn Thr Gln Ala Ala Glu Ala Leu Val Lys Leu
    850                 855                 860                 
Tyr Glu Thr Lys Leu Cys Glu Glu Glu Ala Val Ile Ala Asp Lys Asn
865                 870                 875                 880 
Asn Ile Glu Asn Leu Ile Ser Thr Leu Lys Gln Trp Arg Ser Glu Val
                885                 890                 895     
Asp Glu Lys Arg Gln Val Phe His Ala Leu Glu Asp Glu Leu Gln Lys
            900                 905                 910         
Ala Lys Ala Ile Ser Asp Glu Met Phe Lys Thr Tyr Lys Glu Arg Asp
        915                 920                 925             
Leu Asp Phe Asp Trp His Lys Glu Lys Ala Asp Gln Leu Val Glu Arg
    930                 935                 940                 
Trp Gln Asn Val His Val Gln Ile Asp Asn Arg Leu Arg Asp Leu Glu
945                 950                 955                 960 
Gly Ile Gly Lys Ser Leu Lys Tyr Tyr Arg Asp Thr Tyr His Pro Leu
                965                 970                 975     
Asp Asp Trp Ile Gln Gln Val Glu Thr Thr Gln Arg Lys Ile Gln Glu
            980                 985                 990         
Asn Gln Pro Glu Asn Ser Lys Thr Leu Ala Thr Gln Leu Asn Gln Gln
        995                 1000                1005            
Lys Met Leu Val Ser Glu Ile Glu Met Lys Gln Ser Lys Met Asp Glu
    1010                1015                1020                
Cys Gln Lys Tyr Ala Glu Gln Tyr Ser Ala Thr Val Glu Asp Tyr Glu
1025                1030                1035                1040
Leu Gln Thr Met Thr Tyr Arg Ala Met Val Asp Ser Gln Gln Lys Ser
                1045                1050                1055    
Pro Val Lys Arg Arg Arg Met Gln Ser Ser Ala Asp Leu Ile Ile Gln
            1060                1065                1070        
Glu Phe Met Asp Leu Arg Thr Arg Tyr Thr Ala Leu Val Thr Leu Met
        1075                1080                1085            
Thr Gln Tyr Ile Lys Phe Ala Gly Asp Ser Leu Lys Arg Leu Glu Glu
    1090                1095                1100                
Glu Glu Lys Ser Leu Glu Glu Glu Lys Lys Glu His Val Glu Lys Ala
1105                1110                1115                1120
Lys Glu Leu Gln Lys Trp Val Ser Asn Ile Ser Lys Thr Leu Lys Asp
                1125                1130                1135    
Ala Glu Lys Ala Gly Lys Pro Pro Phe Ser Lys Gln Lys Ile Ser Ser
            1140                1145                1150        
Glu Glu Ile Ser Thr Lys Lys Glu Gln Leu Ser Glu Ala Leu Gln Thr
        1155                1160                1165            
Ile Gln Leu Phe Leu Ala Lys His Gly Asp Lys Met Thr Asp Glu Glu
    1170                1175                1180                
Arg Asn Glu Leu Glu Lys Gln Val Lys Thr Leu Gln Glu Ser Tyr Asn
1185                1190                1195                1200
Leu Leu Phe Ser Glu Ser Leu Lys Gln Leu Gln Glu Ser Gln Thr Ser
                1205                1210                1215    
Gly Asp Val Lys Val Glu Glu Lys Ile Val Ala Glu Arg Gln Gln Glu
            1220                1225                1230        
Tyr Lys Glu Lys Leu Gln Gly Ile Cys Asp Leu Leu Thr Gln Thr Glu
        1235                1240                1245            
Asn Arg Leu Ile Gly His Gln Glu Ala Phe Met Ile Gly Asp Gly Thr
    1250                1255                1260                
Val Glu Leu Lys Lys Tyr Gln Ser Lys Gln Glu Glu Leu Gln Lys Asp
1265                1270                1275                1280
Met Gln Gly Ser Ala Gln Ala Leu Ala Glu Val Val Lys Asn Thr Glu
                1285                1290                1295    
Asn Phe Leu Lys Glu Asn Gly Glu Lys Leu Ser Gln Glu Asp Lys Ala
            1300                1305                1310        
Leu Ile Glu Gln Lys Leu Asn Glu Ala Lys Ile Lys Cys Glu Gln Leu
        1315                1320                1325            
Asn Leu Lys Ala Glu Gln Ser Lys Lys Glu Leu Asp Lys Val Val Thr
    1330                1335                1340                
Thr Ala Ile Lys Glu Glu Thr Glu Lys Val Ala Ala Val Lys Gln Leu
1345                1350                1355                1360
Glu Glu Ser Lys Thr Lys Ile Glu Asn Leu Leu Asp Trp Leu Ser Asn
                1365                1370                1375    
Val Asp Lys Asp Ser Glu Arg Ala Gly Thr Lys His Lys Gln Val Ile
            1380                1385                1390        
Glu Gln Asn Gly Thr His Phe Gln Glu Gly Asp Gly Lys Ser Ala Ile
        1395                1400                1405            
Gly Glu Glu Asp Glu Val Asn Gly Asn Leu Leu Glu Thr Asp Val Asp
    1410                1415                1420                
Gly Gln Val Gly Thr Thr Gln Glu Asn Leu Asn Gln Gln Tyr Gln Lys
1425                1430                1435                1440
Val Lys Ala Gln His Glu Lys Ile Ile Ser Gln His Gln Ala Val Ile
                1445                1450                1455    
Ile Ala Thr Gln Ser Ala Gln Val Leu Leu Glu Lys Gln Gly Gln Tyr
            1460                1465                1470        
Leu Ser Pro Glu Glu Lys Glu Lys Leu Gln Lys Asn Met Lys Glu Leu
        1475                1480                1485            
Lys Val His Tyr Glu Thr Ala Leu Ala Glu Ser Glu Lys Lys Met Lys
    1490                1495                1500                
Leu Thr His Ser Leu Gln Glu Glu Leu Glu Lys Phe Asp Ala Asp Tyr
1505                1510                1515                1520
Thr Glu Phe Glu His Trp Leu Gln Gln Ser Glu Gln Glu Leu Glu Asn
                1525                1530                1535    
Leu Glu Ala Gly Ala Asp Asp Ile Asn Gly Leu Met Thr Lys Leu Lys
            1540                1545                1550        
Arg Gln Lys Ser Phe Ser Glu Asp Val Ile Ser His Lys Gly Asp Leu
        1555                1560                1565            
Arg Tyr Ile Thr Ile Ser Gly Asn Arg Val Leu Glu Ala Ala Lys Ser
    1570                1575                1580                
Cys Ser Lys Arg Asp Gly Gly Lys Val Asp Thr Ser Ala Thr His Arg
1585                1590                1595                1600
Glu Val Gln Arg Lys Leu Asp His Ala Thr Asp Arg Phe Arg Ser Leu
                1605                1610                1615    
Tyr Ser Lys Cys Asn Val Leu Gly Asn Asn Leu Lys Asp Leu Val Asp
            1620                1625                1630        
Lys Tyr Gln His Tyr Glu Asp Ala Ser Cys Gly Leu Leu Ala Gly Leu
        1635                1640                1645            
Gln Ala Cys Glu Ala Thr Ala Ser Lys His Leu Ser Glu Pro Ile Ala
    1650                1655                1660                
Val Asp Pro Lys Asn Leu Gln Arg Gln Leu Glu Glu Thr Lys Ala Leu
1665                1670                1675                1680
Gln Gly Gln Ile Ser Ser Gln Gln Val Ala Val Glu Lys Leu Lys Lys
                1685                1690                1695    
Thr Ala Glu Val Leu Leu Asp Ala Arg Gly Ser Leu Leu Pro Ala Lys
            1700                1705                1710        
Asn Asp Ile Gln Lys Thr Leu Asp Asp Ile Val Gly Arg Tyr Glu Asp
        1715                1720                1725            
Leu Ser Lys Ser Val Asn Glu Arg Asn Glu Lys Leu Gln Ile Thr Leu
    1730                1735                1740                
Thr Arg Ser Leu Ser Val Gln Asp Gly Leu Asp Glu Met Leu Asp Trp
1745                1750                1755                1760
Met Gly Asn Val Glu Ser Ser Leu Lys Glu Gln Gly Gln Val Pro Leu
                1765                1770                1775    
Asn Ser Thr Ala Leu Gln Asp Ile Ile Ser Lys Asn Ile Met Leu Glu
            1780                1785                1790        
Gln Asp Ile Ala Gly Arg Gln Ser Ser Ile Asn Ala Met Asn Glu Lys
        1795                1800                1805            
Val Lys Lys Phe Met Glu Thr Thr Asp Pro Ser Thr Ala Ser Ser Leu
    1810                1815                1820                
Gln Ala Lys Met Lys Asp Leu Ser Ala Arg Phe Ser Glu Ala Ser His
1825                1830                1835                1840
Lys His Lys Glu Thr Leu Ala Lys Met Glu Glu Leu Lys Thr Lys Val
                1845                1850                1855    
Glu Leu Phe Glu Asn Leu Ser Glu Lys Leu Gln Thr Phe Leu Glu Thr
            1860                1865                1870        
Lys Thr Gln Ala Leu Thr Glu Val Asp Val Pro Gly Lys Asp Val Thr
        1875                1880                1885            
Glu Leu Ser Gln Tyr Met Gln Glu Ser Thr Ser Glu Phe Leu Glu His
    1890                1895                1900                
Lys Lys His Leu Glu Val Leu His Ser Leu Leu Lys Glu Ile Ser Ser
1905                1910                1915                1920
His Gly Leu Pro Ser Asp Lys Ala Leu Val Leu Glu Lys Thr Asn Asn
                1925                1930                1935    
Leu Ser Lys Lys Phe Lys Glu Met Glu Asp Thr Ile Lys Glu Lys Lys
            1940                1945                1950        
Glu Ala Val Thr Ser Cys Gln Glu Gln Leu Asp Ala Phe Gln Val Leu
        1955                1960                1965            
Val Lys Ser Leu Lys Ser Trp Ile Lys Glu Thr Thr Lys Lys Val Pro
    1970                1975                1980                
Ile Val Gln Pro Ser Phe Gly Ala Glu Asp Leu Gly Lys Ser Leu Glu
1985                1990                1995                2000
Asp Thr Lys Lys Leu Gln Glu Lys Trp Ser Leu Lys Thr Pro Glu Ile
                2005                2010                2015    
Gln Lys Val Asn Asn Ser Gly Ile Ser Leu Cys Asn Leu Ile Ser Ala
            2020                2025                2030        
Val Thr Thr Pro Ala Lys Ala Ile Ala Ala Val Lys Ser Gly Gly Ala
        2035                2040                2045            
Val Leu Asn Gly Glu Gly Thr Ala Thr Asn Thr Glu Glu Phe Trp Ala
    2050                2055                2060                
Asn Lys Gly Leu Thr Ser Ile Lys Lys Asp Met Thr Asp Ile Ser His
2065                2070                2075                2080
Gly Tyr Glu Asp Leu Gly Leu Leu Leu Lys Asp Lys Ile Ala Glu Leu
                2085                2090                2095    
Asn Thr Lys Leu Ser Lys Leu Gln Lys Ala Gln Glu Glu Ser Ser Ala
            2100                2105                2110        
Met Met Gln Trp Leu Gln Lys Met Asn Lys Thr Ala Thr Lys Trp Gln
        2115                2120                2125            
Gln Thr Pro Ala Pro Thr Asp Thr Glu Ala Val Lys Thr Gln Val Glu
    2130                2135                2140                
Gln Asn Lys Ser Phe Glu Ala Glu Leu Lys Gln Asn Val Asn Lys Val
2145                2150                2155                2160
Gln Glu Leu Lys Asp Lys Leu Thr Glu Leu Leu Glu Glu Asn Pro Asp
                2165                2170                2175    
Thr Pro Glu Ala Pro Arg Trp Lys Gln Met Leu Thr Glu Ile Asp Ser
            2180                2185                2190        
Lys Trp Gln Glu Leu Asn Gln Leu Thr Ile Asp Arg Gln Gln Lys Leu
        2195                2200                2205            
Glu Glu Ser Ser Asn Asn Leu Thr Gln Phe Gln Thr Val Glu Ala Gln
    2210                2215                2220                
Leu Lys Gln Trp Leu Val Glu Lys Glu Leu Met Val Ser Val Leu Gly
2225                2230                2235                2240
Pro Leu Ser Ile Asp Pro Asn Met Leu Asn Thr Gln Arg Gln Gln Val
                2245                2250                2255    
Gln Ile Leu Leu Gln Glu Phe Ala Thr Arg Lys Pro Gln Tyr Glu Gln
            2260                2265                2270        
Leu Thr Ala Ala Gly Gln Gly Ile Leu Ser Arg Pro Gly Glu Asp Pro
        2275                2280                2285            
Ser Leu Arg Gly Ile Val Lys Glu Gln Leu Ala Ala Val Thr Gln Lys
    2290                2295                2300                
Trp Asp Ser Leu Thr Gly Gln Leu Ser Asp Arg Cys Asp Trp Ile Asp
2305                2310                2315                2320
Gln Ala Ile Val Lys Ser Thr Gln Tyr Gln Ser Leu Leu Arg Ser Leu
                2325                2330                2335    
Ser Asp Lys Leu Ser Asp Leu Asp Asn Lys Leu Ser Ser Ser Leu Ala
            2340                2345                2350        
Val Ser Thr His Pro Asp Ala Met Asn Gln Gln Leu Glu Thr Ala Gln
        2355                2360                2365            
Lys Met Lys Gln Glu Ile Gln Gln Glu Lys Lys Gln Ile Lys Val Ala
    2370                2375                2380                
Gln Ala Leu Cys Glu Asp Leu Ser Ala Leu Val Lys Glu Glu Tyr Leu
2385                2390                2395                2400
Lys Ala Glu Leu Ser Arg Gln Leu Glu Gly Ile Leu Lys Ser Phe Lys
                2405                2410                2415    
Asp Val Glu Gln Lys Ala Glu Asn His Val Gln His Leu Gln Ser Ala
            2420                2425                2430        
Cys Ala Ser Ser His Gln Phe Gln Gln Met Ser Arg Asp Phe Gln Ala
        2435                2440                2445            
Trp Leu Asp Thr Lys Lys Glu Glu Gln Asn Lys Ser His Pro Ile Ser
    2450                2455                2460                
Ala Lys Leu Asp Val Leu Glu Ser Leu Ile Lys Asp His Lys Asp Phe
2465                2470                2475                2480
Ser Lys Thr Leu Thr Ala Gln Ser His Met Tyr Glu Lys Thr Ile Ala
                2485                2490                2495    
Glu Gly Glu Asn Leu Leu Leu Lys Thr Gln Gly Ser Glu Lys Ala Ala
            2500                2505                2510        
Leu Gln Leu Gln Leu Asn Thr Ile Lys Thr Asn Trp Asp Thr Phe Asn
        2515                2520                2525            
Lys Gln Val Lys Glu Arg Glu Asn Lys Leu Lys Glu Ser Leu Glu Lys
    2530                2535                2540                
Ala Leu Lys Tyr Lys Glu Gln Val Glu Thr Leu Trp Pro Trp Ile Asp
2545                2550                2555                2560
Lys Cys Gln Asn Asn Leu Glu Glu Ile Lys Phe Cys Leu Asp Pro Ala
                2565                2570                2575    
Glu Gly Glu Asn Ser Ile Ala Lys Leu Lys Ser Leu Gln Lys Glu Met
            2580                2585                2590        
Asp Gln His Phe Gly Met Val Glu Leu Leu Asn Asn Thr Ala Asn Ser
        2595                2600                2605            
Leu Leu Ser Val Cys Glu Ile Asp Lys Gly Val Val Thr Asp Glu Asn
    2610                2615                2620                
Lys Ser Leu Ile Gln Lys Val Asp Met Val Thr Glu Gln Leu His Ser
2625                2630                2635                2640
Lys Lys Phe Cys Leu Glu Asn Met Thr Gln Lys Phe Lys Glu Phe Gln
                2645                2650                2655    
Glu Val Ser Lys Glu Ser Lys Arg Gln Leu Gln Cys Ala Lys Glu Gln
            2660                2665                2670        
Leu Asp Ile His Asp Ser Leu Gly Ser Gln Ala Tyr Ser Asn Lys Tyr
        2675                2680                2685            
Leu Thr Met Leu Gln Thr Gln Gln Lys Ser Leu Gln Ala Leu Lys His
    2690                2695                2700                
Gln Val Asp Leu Ala Lys Arg Leu Ala Gln Asp Leu Val Val Glu Ala
2705                2710                2715                2720
Ser Asp Ser Lys Gly Thr Ser Asp Val Leu Leu Gln Val Glu Thr Ile
                2725                2730                2735    
Ala Gln Glu His Ser Thr Leu Ser Gln Gln Val Asp Glu Lys Cys Ser
            2740                2745                2750        
Phe Leu Glu Thr Lys Leu Gln Gly Ile Gly His Phe Arg Asn Thr Ile
        2755                2760                2765            
Arg Glu Met Phe Ser Gln Phe Ala Glu Phe Asp Asp Glu Leu Asp Ser
    2770                2775                2780                
Met Ala Pro Val Gly Arg Asp Ala Glu Thr Leu Gln Lys Gln Lys Glu
2785                2790                2795                2800
Thr Ile Lys Ala Phe Leu Lys Lys Leu Glu Ala Leu Met Ala Ser Asn
                2805                2810                2815    
Asp Asn Ala Asn Lys Thr Cys Lys Met Met Leu Ala Thr Glu Glu Thr
            2820                2825                2830        
Ser Pro Asp Leu Val Gly Ile Lys Arg Asp Leu Glu Ala Leu Ser Lys
        2835                2840                2845            
Gln Cys Asn Lys Leu Leu Asp Arg Ala Gln Ala Arg Glu Glu Gln Val
    2850                2855                2860                
Glu Gly Thr Ile Lys Arg Leu Glu Glu Phe Tyr Ser Lys Leu Lys Glu
2865                2870                2875                2880
Phe Ser Ile Leu Leu Gln Arg Ala Glu Glu His Glu Glu Ser Gln Gly
                2885                2890                2895    
Pro Val Gly Met Glu Thr Glu Thr Ile Asn Gln Gln Leu Asn Met Phe
            2900                2905                2910        
Lys Val Phe Gln Lys Glu Glu Ile Glu Pro Leu Gln Gly Lys Gln Gln
        2915                2920                2925            
Asp Val Asn Trp Leu Gly Gln Gly Leu Ile Gln Ser Ala Ala Lys Ser
    2930                2935                2940                
Thr Ser Thr Gln Gly Leu Glu His Asp Leu Asp Asp Val Asn Ala Arg
2945                2950                2955                2960
Trp Lys Thr Leu Asn Lys Lys Val Ala Gln Arg Ala Ala Gln Leu Gln
                2965                2970                2975    
Glu Ala Leu Leu His Cys Gly Arg Phe Gln Asp Ala Leu Glu Ser Leu
            2980                2985                2990        
Leu Ser Trp Met Val Asp Thr Glu Glu Leu Val Ala Asn Gln Lys Pro
        2995                3000                3005            
Pro Ser Ala Glu Phe Lys Val Val Lys Ala Gln Ile Gln Glu Gln Lys
    3010                3015                3020                
Leu Leu Gln Arg Leu Leu Asp Asp Arg Lys Ser Thr Val Glu Val Ile
3025                3030                3035                3040
Lys Arg Glu Gly Glu Lys Ile Ala Thr Thr Ala Glu Pro Ala Asp Lys
                3045                3050                3055    
Val Lys Ile Leu Lys Gln Leu Ser Leu Leu Asp Ser Arg Trp Glu Ala
            3060                3065                3070        
Leu Leu Asn Lys Ala Glu Thr Arg Asn Arg Gln Leu Glu Gly Ile Ser
        3075                3080                3085            
Val Val Ala Gln Gln Phe His Glu Thr Leu Glu Pro Leu Asn Glu Trp
    3090                3095                3100                
Leu Thr Thr Ile Glu Lys Arg Leu Val Asn Cys Glu Pro Ile Gly Thr
3105                3110                3115                3120
Gln Ala Ser Lys Leu Glu Glu Gln Ile Ala Gln His Lys Ala Leu Glu
                3125                3130                3135    
Asp Asp Ile Ile Asn His Asn Lys His Leu His Gln Ala Val Ser Ile
            3140                3145                3150        
Gly Gln Ser Leu Lys Val Leu Ser Ser Arg Glu Asp Lys Asp Met Val
        3155                3160                3165            
Gln Ser Lys Leu Asp Phe Ser Gln Val Trp Tyr Ile Glu Ile Gln Glu
    3170                3175                3180                
Lys Ser His Ser Arg Ser Glu Leu Leu Gln Gln Ala Leu Cys Asn Ala
3185                3190                3195                3200
Lys Ile Phe Gly Glu Asp Glu Val Glu Leu Met Asn Trp Leu Asn Glu
                3205                3210                3215    
Val His Asp Lys Leu Ser Lys Leu Ser Val Gln Asp Tyr Ser Thr Glu
            3220                3225                3230        
Gly Leu Trp Lys Gln Gln Ser Glu Leu Arg Val Leu Gln Glu Asp Ile
        3235                3240                3245            
Leu Leu Arg Lys Gln Asn Val Asp Gln Ala Leu Leu Asn Gly Leu Glu
    3250                3255                3260                
Leu Leu Lys Gln Thr Thr Gly Asp Glu Val Leu Ile Ile Gln Asp Lys
3265                3270                3275                3280
Leu Glu Ala Ile Lys Ala Arg Tyr Lys Asp Ile Thr Lys Leu Ser Thr
                3285                3290                3295    
Asp Val Ala Lys Thr Leu Glu Gln Ala Leu Gln Leu Ala Arg Arg Leu
            3300                3305                3310        
His Ser Thr His Glu Glu Leu Cys Thr Trp Leu Asp Lys Val Glu Val
        3315                3320                3325            
Glu Leu Leu Ser Tyr Glu Thr Gln Val Leu Lys Gly Glu Glu Ala Ser
    3330                3335                3340                
Gln Ala Gln Met Arg Pro Lys Glu Leu Lys Lys Glu Ala Lys Asn Asn
3345                3350                3355                3360
Lys Ala Leu Leu Asp Ser Leu Asn Glu Val Ser Ser Ala Leu Leu Glu
                3365                3370                3375    
Leu Val Pro Trp Arg Ala Arg Glu Gly Leu Glu Lys Met Val Ala Glu
            3380                3385                3390        
Asp Asn Glu Arg Tyr Arg Leu Val Ser Asp Thr Ile Thr Gln Lys Val
        3395                3400                3405            
Glu Glu Val Asp Ala Ala Ile Leu Arg Ser Gln Gln Phe Asp Gln Ala
    3410                3415                3420                
Ala Asp Ala Glu Leu Ser Trp Ile Thr Glu Thr Glu Lys Lys Leu Met
3425                3430                3435                3440
Ser Leu Gly Asp Ile Arg Leu Glu Gln Asp Gln Thr Ser Ala Gln Leu
                3445                3450                3455    
Gln Val Gln Lys Thr Phe Thr Met Glu Ile Leu Arg His Arg Asp Ile
            3460                3465                3470        
Ile Asp Asp Leu Val Lys Ser Gly His Lys Ile Met Thr Ala Cys Ser
        3475                3480                3485            
Glu Glu Glu Lys Gln Ser Met Lys Lys Lys Leu Asp Lys Val Leu Lys
    3490                3495                3500                
Asn Tyr Asp Thr Ile Cys Gln Ile Asn Ser Glu Arg Tyr Leu Gln Leu
3505                3510                3515                3520
Glu Arg Ala Gln Ser Leu Val Asn Gln Phe Trp Glu Thr Tyr Glu Glu
                3525                3530                3535    
Leu Trp Pro Trp Leu Thr Glu Thr Gln Ser Ile Ile Ser Gln Leu Pro
            3540                3545                3550        
Ala Pro Ala Leu Glu Tyr Glu Thr Leu Arg Gln Gln Gln Glu Glu His
        3555                3560                3565            
Arg Gln Leu Arg Glu Ser Ile Ala Glu His Lys Pro His Ile Asp Lys
    3570                3575                3580                
Met Asn Lys Thr Gly Pro Gln Leu Leu Glu Leu Ser Pro Gly Glu Gly
3585                3590                3595                3600
Phe Ser Ile Gln Glu Lys Tyr Val Ala Ala Asp Thr Leu Tyr Ser Gln
                3605                3610                3615    
Ile Lys Glu Asp Val Lys Lys Arg Ala Val Ala Leu Asp Glu Ala Ile
            3620                3625                3630        
Ser Gln Ser Thr Gln Phe His Asp Lys Ile Asp Gln Ile Leu Glu Ser
        3635                3640                3645            
Leu Glu Arg Ile Val Glu Arg Leu Arg Gln Pro Pro Ser Ile Ser Ala
    3650                3655                3660                
Glu Val Glu Lys Ile Lys Glu Gln Ile Ser Glu Asn Lys Asn Val Ser
3665                3670                3675                3680
Val Asp Met Glu Lys Leu Gln Pro Leu Tyr Glu Thr Leu Lys Gln Arg
                3685                3690                3695    
Gly Glu Glu Met Ile Ala Arg Ser Gly Gly Thr Asp Lys Asp Ile Ser
            3700                3705                3710        
Ala Lys Ala Val Gln Asp Lys Leu Asp Gln Met Val Phe Ile Trp Glu
        3715                3720                3725            
Asn Ile His Thr Leu Val Glu Glu Arg Glu Ala Lys Leu Leu Asp Val
    3730                3735                3740                
Met Glu Leu Ala Glu Lys Phe Trp Cys Asp His Met Ser Leu Ile Val
3745                3750                3755                3760
Thr Ile Lys Asp Thr Gln Asp Phe Ile Arg Asp Leu Glu Gly Pro Gly
                3765                3770                3775    
Ile Asp Pro Ser Val Val Lys Gln Gln Gln Glu Ala Ala Glu Thr Ile
            3780                3785                3790        
Arg Glu Glu Ile Asp Gly Leu Gln Glu Glu Leu Asp Ile Val Ile Asn
        3795                3800                3805            
Leu Gly Ser Glu Leu Ile Ala Ala Cys Gly Glu Pro Asp Lys Pro Ile
    3810                3815                3820                
Val Lys Lys Ser Ile Asp Glu Leu Asn Ser Ala Trp Asp Ser Leu Asn
3825                3830                3835                3840
Lys Ala Trp Lys Asp Arg Ile Asp Lys Leu Glu Glu Ala Met Gln Ala
                3845                3850                3855    
Ala Val Gln Tyr Gln Asp Gly Leu Gln Ala Val Phe Asp Trp Val Asp
            3860                3865                3870        
Ile Ala Gly Gly Lys Leu Ala Ser Met Ser Pro Ile Gly Thr Asp Leu
        3875                3880                3885            
Glu Thr Val Lys Gln Gln Ile Glu Glu Leu Lys Gln Phe Lys Ser Glu
    3890                3895                3900                
Ala Tyr Gln Gln Gln Ile Glu Met Glu Arg Leu Asn His Gln Ala Glu
3905                3910                3915                3920
Leu Leu Leu Lys Lys Val Thr Glu Glu Ser Asp Lys His Thr Val Gln
                3925                3930                3935    
Asp Pro Leu Met Glu Leu Lys Leu Ile Trp Asp Ser Leu Glu Glu Arg
            3940                3945                3950        
Ile Ile Asn Arg Gln His Lys Leu Glu Gly Ala Leu Leu Ala Leu Gly
        3955                3960                3965            
Gln Phe Gln His Ala Leu Asp Glu Leu Leu Ala Trp Leu Thr His Thr
    3970                3975                3980                
Glu Gly Leu Leu Ser Glu Gln Lys Pro Val Gly Gly Asp Pro Lys Ala
3985                3990                3995                4000
Ile Glu Ile Glu Leu Ala Lys His His Val Leu Gln Asn Asp Val Leu
                4005                4010                4015    
Ala His Gln Ser Thr Val Glu Ala Val Asn Lys Gly Gly Asn Asp Leu
            4020                4025                4030        
Ile Glu Ser Ser Ala Gly Glu Glu Ala Ser Asn Leu Gln Asn Lys Leu
        4035                4040                4045            
Glu Val Leu Asn Gln Arg Trp Gln Asn Val Leu Glu Lys Thr Glu Gln
    4050                4055                4060                
Arg Lys Gln Gln Leu Asp Gly Ala Leu Arg Gln Ala Lys Gly Phe His
4065                4070                4075                4080
Gly Glu Ile Glu Asp Leu Gln Gln Trp Leu Thr Asp Thr Glu Arg His
                4085                4090                4095    
Leu Leu Ala Ser Lys Pro Leu Gly Gly Leu Pro Glu Thr Ala Lys Glu
            4100                4105                4110        
Gln Leu Asn Val His Met Glu Val Cys Ala Ala Phe Glu Ala Lys Glu
        4115                4120                4125            
Glu Thr Tyr Lys Ser Leu Met Gln Lys Gly Gln Gln Met Leu Ala Arg
    4130                4135                4140                
Cys Pro Lys Ser Ala Glu Thr Asn Ile Asp Gln Asp Ile Asn Asn Leu
4145                4150                4155                4160
Lys Glu Lys Trp Glu Ser Val Glu Thr Lys Leu Asn Glu Arg Lys Thr
                4165                4170                4175    
Lys Leu Glu Glu Ala Leu Asn Leu Ala Met Glu Phe His Asn Ser Leu
            4180                4185                4190        
Gln Asp Phe Ile Asn Trp Leu Thr Gln Ala Glu Gln Thr Leu Asn Val
        4195                4200                4205            
Ala Ser Arg Pro Ser Leu Ile Leu Asp Thr Val Leu Phe Gln Ile Asp
    4210                4215                4220                
Glu His Lys Val Phe Ala Asn Glu Val Asn Ser His Arg Glu Gln Ile
4225                4230                4235                4240
Ile Glu Leu Asp Lys Thr Gly Thr His Leu Lys Tyr Phe Ser Gln Lys
                4245                4250                4255    
Gln Asp Val Val Leu Ile Lys Asn Leu Leu Ile Ser Val Gln Ser Arg
            4260                4265                4270        
Trp Glu Lys Val Val Gln Arg Leu Val Glu Arg Gly Arg Ser Leu Asp
        4275                4280                4285            
Asp Ala Arg Lys Arg Ala Lys Gln Phe His Glu Ala Trp Ser Lys Leu
    4290                4295                4300                
Met Glu Trp Leu Glu Glu Ser Glu Lys Ser Leu Asp Ser Glu Leu Glu
4305                4310                4315                4320
Ile Ala Asn Asp Pro Asp Lys Ile Lys Thr Gln Leu Ala Gln His Lys
                4325                4330                4335    
Glu Phe Gln Lys Ser Leu Gly Ala Lys His Ser Val Tyr Asp Thr Thr
            4340                4345                4350        
Asn Arg Thr Gly Arg Ser Leu Lys Glu Lys Thr Ser Leu Ala Asp Asp
        4355                4360                4365            
Asn Leu Lys Leu Asp Asp Met Leu Ser Glu Leu Arg Asp Lys Trp Asp
    4370                4375                4380                
Thr Ile Cys Gly Lys Ser Val Glu Arg Gln Asn Lys Leu Glu Glu Ala
4385                4390                4395                4400
Leu Leu Phe Ser Gly Gln Phe Thr Asp Ala Leu Gln Ala Leu Ile Asp
                4405                4410                4415    
Trp Leu Tyr Arg Val Glu Pro Gln Leu Ala Glu Asp Gln Pro Val His
            4420                4425                4430        
Gly Asp Ile Asp Leu Val Met Asn Leu Ile Asp Asn His Lys Ala Phe
        4435                4440                4445            
Gln Lys Glu Leu Gly Lys Arg Thr Ser Ser Val Gln Ala Leu Lys Arg
    4450                4455                4460                
Ser Ala Arg Glu Leu Ile Xaa Gly Ser Arg Asp Asp Ser Ser Trp Val
4465                4470                4475                4480
Lys Val Gln Met Gln Glu Leu Ser Thr Arg Trp Glu Thr Val Cys Ala
                4485                4490                4495    
Leu Ser Ile Ser Lys Gln Thr Arg Leu Glu Ala Ala Leu Arg Gln Ala
            4500                4505                4510        
Glu Glu Phe His Ser Val Val His Ala Leu Leu Glu Trp Leu Ala Glu
        4515                4520                4525            
Ala Glu Gln Thr Leu Arg Phe His Gly Val Leu Pro Asp Asp Glu Asp
    4530                4535                4540                
Ala Leu Arg Thr Leu Ile Asp Gln His Lys Glu Phe Met Lys Lys Leu
4545                4550                4555                4560
Glu Glu Lys Arg Ala Glu Leu Asn Lys Ala Thr Thr Met Gly Asp Thr
                4565                4570                4575    
Val Leu Ala Ile Cys His Pro Asp Ser Ile Thr Thr Ile Lys His Trp
            4580                4585                4590        
Ile Thr Ile Ile Arg Ala Arg Phe Glu Glu Val Leu Ala Trp Ala Lys
        4595                4600                4605            
Gln His Gln Gln Arg Leu Ala Ser Ala Leu Ala Gly Leu Ile Ala Lys
    4610                4615                4620                
Gln Glu Leu Leu Glu Ala Leu Leu Ala Trp Leu Gln Trp Ala Glu Thr
4625                4630                4635                4640
Thr Leu Thr Asp Lys Asp Lys Glu Val Ile Pro Gln Glu Ile Glu Glu
                4645                4650                4655    
Val Lys Ala Leu Ile Ala Glu His Gln Thr Phe Met Glu Glu Met Thr
            4660                4665                4670        
Arg Lys Gln Pro Asp Val Asp Lys Val Thr Lys Thr Tyr Lys Arg Arg
        4675                4680                4685            
Ala Ala Asp Pro Ser Ser Leu Gln Ser His Ile Pro Val Leu Asp Lys
    4690                4695                4700                
Gly Arg Ala Gly Arg Lys Arg Phe Pro Ala Ser Ser Leu Tyr Pro Ser
4705                4710                4715                4720
Gly Ser Gln Thr Gln Ile Glu Thr Lys Asn Pro Arg Val Asn Leu Leu
                4725                4730                4735    
Val Ser Lys Trp Gln Gln Val Trp Leu Leu Ala Leu Glu Arg Arg Arg
            4740                4745                4750        
Lys Leu Asn Asp Ala Leu Asp Arg Leu Glu Glu Leu Arg Glu Phe Ala
        4755                4760                4765            
Asn Phe Asp Phe Asp Ile Trp Arg Lys Lys Tyr Met Arg Trp Met Asn
    4770                4775                4780                
His Lys Lys Ser Arg Val Met Asp Phe Phe Arg Arg Ile Asp Lys Asp
4785                4790                4795                4800
Gln Asp Gly Lys Ile Thr Arg Gln Glu Phe Ile Asp Gly Ile Leu Ser
                4805                4810                4815    
Ser Lys Phe Pro Thr Ser Arg Leu Glu Met Ser Ala Val Ala Asp Ile
            4820                4825                4830        
Phe Asp Arg Asp Gly Asp Gly Tyr Ile Asp Tyr Tyr Glu Phe Val Ala
        4835                4840                4845            
Ala Leu His Pro Asn Lys Asp Ala Tyr Lys Pro Ile Thr Asp Ala Asp
    4850                4855                4860                
Lys Ile Glu Asp Glu Val Thr Arg Gln Val Ala Lys Cys Lys Cys Ala
4865                4870                4875                4880
Lys Arg Phe Gln Val Glu Gln Ile Gly Asp Asn Lys Tyr Arg Phe Phe
                4885                4890                4895    
Leu Gly Asn Gln Phe Gly Asp Ser Gln Gln Leu Arg Leu Val Arg Ile
            4900                4905                4910        
Leu Arg Ser Thr Val Met Val Arg Val Gly Gly Gly Trp Met Ala Leu
        4915                4920                4925            
Asp Glu Phe Leu Val Lys Asn Asp Pro Cys Arg Ala Lys Gly Arg Thr
    4930                4935                4940                
Asn Met Glu Leu Arg Glu Lys Phe Ile Leu Ala Asp Gly Ala Ser Gln
4945                4950                4955                4960
Gly Met Ala Ala Phe Arg Pro Arg Gly Arg Arg Ser Arg Pro Ser Ser
                4965                4970                4975    
Arg Gly Ala Ser Pro Asn Arg Ser Thr Ser Val Ser Ser Gln Ala Ala
            4980                4985                4990        
Gln Ala Ala Ser Pro Gln Val Pro Ala Thr Thr Thr Pro Lys Ile Leu
        4995                5000                5005            
His Pro Leu Thr Arg Asn Tyr Gly Lys Pro Trp Leu Thr Asn Ser Lys
    5010                5015                5020                
Met Ser Thr Pro Cys Lys Ala Ala Glu Cys Ser Asp Phe Pro Val Pro
5025                5030                5035                5040
Ser Ala Glu Gly Thr Pro Ile Gln Gly Ser Lys Leu Arg Leu Pro Gly
                5045                5050                5055    
Tyr Leu Ser Gly Lys Gly Phe His Ser Gly Glu Asp Ser Gly Leu Ile
            5060                5065                5070        
Thr Thr Ala Ala Ala Arg Val Arg Thr Gln Phe Ala Asp Ser Lys Lys
        5075                5080                5085            
Thr Pro Ser Arg Pro Gly Ser Arg Ala Gly Ser Lys Ala Gly Ser Arg
    5090                5095                5100                
Ala Ser Ser Arg Arg Gly Ser Asp Ala Ser Asp Phe Asp Ile Ser Glu
5105                5110                5115                5120
Ile Gln Ser Val Cys Ser Asp Val Glu Thr Val Pro Gln Thr His Arg
                5125                5130                5135    
Pro Thr Pro Arg Ala Gly Ser Arg Pro Ser Thr Ala Lys Pro Ser Lys
            5140                5145                5150        
Ile Pro Thr Pro Gln Arg Lys Ser Pro Ala Ser Lys Leu Asp Lys Ser
        5155                5160                5165            
Ser Lys Arg
    5170    


<210> 2688
<211> 797
<212> PRT
<213> Homo sapiens

<400> 2688
Met Ala Ala Ala Pro Val Ala Ala Gly Ser Gly Ala Gly Arg Gly Arg
 1               5                  10                  15      
Arg Ser Ala Ala Thr Val Ala Ala Trp Gly Gly Trp Gly Gly Arg Pro
            20                  25                  30          
Arg Pro Gly Asn Ile Leu Leu Gln Leu Arg Gln Gly Gln Leu Thr Gly
        35                  40                  45              
Arg Gly Leu Val Arg Ala Val Gln Phe Thr Glu Thr Phe Leu Thr Glu
    50                  55                  60                  
Arg Asp Lys Gln Ser Lys Trp Ser Gly Ile Pro Gln Leu Leu Leu Lys
65                  70                  75                  80  
Leu His Thr Thr Ser His Leu His Ser Asp Phe Val Glu Cys Gln Asn
                85                  90                  95      
Ile Leu Lys Glu Ile Ser Pro Leu Leu Ser Met Glu Ala Met Ala Phe
            100                 105                 110         
Val Thr Glu Glu Arg Lys Leu Thr Gln Glu Thr Thr Tyr Pro Asn Thr
        115                 120                 125             
Tyr Ile Phe Asp Leu Phe Gly Gly Val Asp Leu Leu Val Glu Ile Leu
    130                 135                 140                 
Met Arg Pro Thr Ile Ser Ile Arg Gly Gln Lys Leu Lys Ile Ser Asp
145                 150                 155                 160 
Glu Met Ser Lys Asp Cys Leu Ser Ile Leu Tyr Asn Thr Cys Val Cys
                165                 170                 175     
Thr Glu Gly Val Thr Lys Arg Leu Ala Glu Lys Asn Asp Phe Val Ile
            180                 185                 190         
Phe Leu Phe Thr Leu Met Thr Ser Lys Lys Thr Phe Leu Gln Thr Ala
        195                 200                 205             
Thr Leu Ile Glu Asp Ile Leu Gly Val Lys Lys Glu Met Ile Arg Leu
    210                 215                 220                 
Asp Glu Val Pro Asn Leu Ser Ser Leu Val Ser Asn Phe Asp Gln Gln
225                 230                 235                 240 
Gln Leu Ala Asn Phe Cys Arg Ile Leu Ala Val Thr Ile Ser Glu Met
                245                 250                 255     
Asp Thr Gly Asn Asp Asp Lys His Thr Leu Leu Ala Lys Asn Ala Gln
            260                 265                 270         
Gln Lys Lys Ser Leu Ser Leu Gly Pro Ser Ala Ala Glu Ile Asn Gln
        275                 280                 285             
Ala Ala Leu Leu Ser Ile Pro Gly Phe Val Glu Arg Leu Cys Lys Leu
    290                 295                 300                 
Ala Thr Arg Lys Val Ser Glu Ser Thr Gly Thr Ala Ser Phe Leu Gln
305                 310                 315                 320 
Glu Leu Glu Glu Trp Tyr Thr Trp Leu Asp Asn Ala Leu Val Leu Asp
                325                 330                 335     
Ala Leu Met Arg Val Ala Asn Glu Glu Ser Glu His Asn Gln Ala Ser
            340                 345                 350         
Ile Val Phe Pro Pro Pro Gly Ala Ser Glu Glu Asn Gly Leu Pro His
        355                 360                 365             
Thr Ser Ala Arg Thr Gln Leu Pro Gln Ser Met Lys Ile Met His Glu
    370                 375                 380                 
Ile Met Tyr Lys Leu Glu Val Leu Tyr Val Leu Cys Val Leu Leu Met
385                 390                 395                 400 
Gly Arg Gln Arg Asn Gln Val His Arg Met Ile Ala Glu Phe Lys Leu
                405                 410                 415     
Ile Pro Gly Leu Asn Asn Leu Phe Asp Lys Leu Ile Trp Arg Lys His
            420                 425                 430         
Ser Ala Ser Ala Leu Val Leu His Gly His Asn Gln Asn Cys Asp Cys
        435                 440                 445             
Ser Pro Asp Ile Thr Leu Lys Ile Gln Phe Leu Arg Leu Leu Gln Ser
    450                 455                 460                 
Phe Ser Asp His His Glu Asn Lys Tyr Leu Leu Leu Asn Asn Gln Glu
465                 470                 475                 480 
Leu Asn Glu Leu Ser Ala Ile Ser Leu Lys Ala Asn Ile Pro Glu Val
                485                 490                 495     
Glu Ala Val Leu Asn Thr Asp Arg Ser Leu Val Cys Asp Gly Lys Arg
            500                 505                 510         
Gly Leu Leu Thr Arg Leu Leu Gln Val Met Lys Lys Glu Pro Ala Glu
        515                 520                 525             
Ser Ser Phe Arg Phe Trp Gln Ala Arg Ala Val Glu Ser Phe Leu Arg
    530                 535                 540                 
Gly Thr Thr Ser Tyr Ala Asp Gln Met Phe Leu Leu Lys Arg Gly Leu
545                 550                 555                 560 
Leu Glu His Ile Leu Tyr Cys Ile Val Asp Ser Glu Cys Lys Ser Arg
                565                 570                 575     
Asp Val Leu Gln Ser Tyr Phe Asp Leu Leu Gly Glu Leu Met Lys Phe
            580                 585                 590         
Asn Val Asp Ala Phe Lys Arg Phe Asn Lys Tyr Ile Asn Thr Asp Ala
        595                 600                 605             
Lys Phe Gln Val Phe Leu Lys Gln Ile Asn Ser Ser Leu Val Asp Ser
    610                 615                 620                 
Asn Met Leu Val Arg Cys Val Thr Leu Ser Leu Asp Arg Phe Glu Asn
625                 630                 635                 640 
Gln Val Asp Met Lys Val Ala Glu Val Leu Ser Glu Cys Arg Leu Leu
                645                 650                 655     
Ala Tyr Ile Ser Gln Val Pro Thr Gln Met Ser Phe Leu Phe Arg Leu
            660                 665                 670         
Ile Asn Ile Ile His Val Gln Thr Leu Thr Gln Glu Asn Val Ser Cys
        675                 680                 685             
Leu Asn Thr Ser Leu Val Ile Leu Met Leu Ala Arg Arg Lys Glu Arg
    690                 695                 700                 
Leu Pro Leu Tyr Leu Arg Leu Leu Gln Arg Met Glu His Ser Lys Lys
705                 710                 715                 720 
Tyr Pro Gly Phe Leu Leu Asn Asn Phe His Asn Leu Leu Arg Phe Trp
                725                 730                 735     
Gln Gln His Tyr Leu His Lys Asp Lys Asp Ser Thr Cys Leu Glu Asn
            740                 745                 750         
Ser Ser Cys Ile Ser Phe Ser Tyr Trp Lys Glu Thr Val Ser Ile Leu
        755                 760                 765             
Leu Asn Pro Asp Arg Gln Ser Pro Ser Ala Leu Val Ser Tyr Ile Glu
    770                 775                 780                 
Glu Pro Tyr Met Asp Ile Asp Arg Asp Phe Thr Glu Glu
785                 790                 795         


<210> 2689
<211> 593
<212> PRT
<213> Homo sapiens

<400> 2689
Met Ser Val Arg Leu Arg Phe Leu Ser Pro Gly Asp Thr Gly Ala Val
 1               5                  10                  15      
Gly Val Val Gly Arg Ser Ala Ser Phe Ala Gly Phe Ser Ser Ala Gln
            20                  25                  30          
Ser Arg Arg Ile Ala Lys Ser Ile Asn Arg Asn Ser Val Arg Ser Arg
        35                  40                  45              
Met Pro Ala Lys Ser Ser Lys Met Tyr Gly Thr Leu Arg Lys Gly Ser
    50                  55                  60                  
Val Cys Ala Asp Pro Lys Pro Gln Gln Val Lys Lys Ile Phe Glu Ala
65                  70                  75                  80  
Leu Lys Arg Gly Leu Lys Glu Tyr Leu Cys Val Gln Gln Ala Glu Leu
                85                  90                  95      
Asp His Leu Ser Gly Arg His Lys Asp Thr Arg Arg Asn Ser Arg Leu
            100                 105                 110         
Ala Phe Tyr Tyr Asp Leu Asp Lys Gln Thr Arg Cys Val Glu Arg His
        115                 120                 125             
Ile Arg Lys Met Glu Phe His Ile Ser Lys Val Asp Glu Leu Tyr Glu
    130                 135                 140                 
Asp Tyr Cys Ile Gln Cys Arg Leu Arg Asp Gly Ala Ser Ser Met Gln
145                 150                 155                 160 
Arg Ala Phe Ala Arg Cys Pro Pro Ser Arg Ala Ala Arg Glu Ser Leu
                165                 170                 175     
Gln Glu Leu Gly Arg Ser Leu His Glu Cys Ala Glu Asp Met Trp Leu
            180                 185                 190         
Ile Glu Gly Ala Leu Glu Val His Leu Gly Glu Phe His Ile Arg Met
        195                 200                 205             
Lys Gly Leu Val Gly Tyr Ala Arg Leu Cys Pro Gly Asp His Tyr Glu
    210                 215                 220                 
Val Leu Met Arg Leu Gly Arg Gln Arg Trp Lys Leu Lys Gly Arg Ile
225                 230                 235                 240 
Glu Ser Asp Asp Ser Gln Thr Trp Asp Glu Glu Glu Lys Ala Phe Ile
                245                 250                 255     
Pro Thr Leu His Glu Asn Leu Asp Ile Lys Val Thr Glu Leu Arg Gly
            260                 265                 270         
Leu Gly Ser Leu Ala Val Gly Ala Val Thr Cys Asp Ile Ala Asp Phe
        275                 280                 285             
Phe Thr Thr Arg Pro Gln Val Ile Val Val Asp Ile Thr Glu Leu Gly
    290                 295                 300                 
Thr Ile Lys Leu Gln Leu Glu Val Gln Trp Asn Pro Phe Asp Thr Glu
305                 310                 315                 320 
Ser Phe Leu Val Ser Pro Ser Pro Thr Gly Lys Phe Ser Met Gly Ser
                325                 330                 335     
Arg Lys Gly Ser Leu Tyr Asn Trp Thr Pro Pro Ser Thr Pro Ser Phe
            340                 345                 350         
Arg Glu Arg Tyr Tyr Leu Ser Val Leu Gln Gln Pro Thr Gln Gln Ala
        355                 360                 365             
Leu Leu Leu Gly Gly Pro Arg Ala Thr Ser Ile Leu Ser Tyr Leu Ser
    370                 375                 380                 
Asp Ser Asp Leu Arg Gly Pro Ser Leu Arg Ser Gln Ser Gln Glu Leu
385                 390                 395                 400 
Pro Glu Met Asp Ser Phe Ser Ser Glu Asp Pro Arg Asp Thr Glu Thr
                405                 410                 415     
Ser Thr Ser Ala Ser Thr Ser Asp Val Gly Phe Leu Pro Leu Thr Phe
            420                 425                 430         
Gly Pro His Ala Ser Ile Glu Glu Glu Ala Arg Glu Asp Pro Leu Pro
        435                 440                 445             
Pro Gly Leu Leu Pro Glu Met Ala His Leu Ser Gly Gly Pro Phe Ala
    450                 455                 460                 
Glu Gln Pro Gly Trp Arg Asn Leu Gly Gly Glu Ser Pro Ser Leu Pro
465                 470                 475                 480 
Gln Gly Ser Leu Phe His Ser Gly Thr Ala Ser Ser Ser Gln Asn Gly
                485                 490                 495     
His Glu Glu Gly Ala Thr Gly Asp Arg Glu Asp Gly Pro Gly Val Ala
            500                 505                 510         
Leu Glu Gly Pro Leu Gln Glu Val Leu Glu Leu Leu Arg Pro Thr Asp
        515                 520                 525             
Ser Thr Gln Pro Gln Leu Arg Glu Leu Glu Tyr Gln Val Leu Gly Phe
    530                 535                 540                 
Arg Asp Arg Leu Lys Pro Cys Arg Ala Arg Gln Glu Leu Thr Ser Ala
545                 550                 555                 560 
Glu Ser Leu Ile Glu Cys Ile Leu Glu Ser Phe Ala Phe Leu Asn Ala
                565                 570                 575     
Asp Phe Ala Pro Asp Glu Leu Ser Leu Phe Gly Gly Ser Gln Gly Leu
            580                 585                 590         
Arg
    


<210> 2690
<211> 648
<212> PRT
<213> Homo sapiens

<400> 2690
Met Val Ser Leu Pro Pro Pro Gln Ser Asp Val Thr Leu Pro Gly Pro
 1               5                  10                  15      
Thr Arg Leu Glu Gly Glu Arg Gln Gly Asp Leu Met Gln Ala Pro Gly
            20                  25                  30          
Leu Pro Gly Ser Pro Ala Pro Gln Ser Lys His Ala Gly Phe Ser Cys
        35                  40                  45              
Ser Ser Phe Val Ser Asp Gly Pro Pro Glu Arg Thr Pro Ser Leu Pro
    50                  55                  60                  
Pro His Ser Pro Arg Ile Ala Ser Pro Gly Pro Glu Gln Val Gln Gly
65                  70                  75                  80  
His Cys Pro Ala Gly Pro Gly Pro Gly Pro Phe Arg Leu Ser Pro Ser
                85                  90                  95      
Asp Lys Tyr Pro Gly Phe Gly Phe Glu Glu Ala Ala Ala Ser Ser Pro
            100                 105                 110         
Gly Arg Phe Leu Lys Gly Ser His Ala Pro Phe His Pro Tyr Lys Arg
        115                 120                 125             
Pro Phe His Glu Asp Val Phe Pro Glu Ala Glu Thr Thr Leu Ala Leu
    130                 135                 140                 
Lys Gly His Ser Phe Lys Thr Pro Gly Pro Leu Glu Ala Phe Glu Glu
145                 150                 155                 160 
Ile Pro Val Asp Val Ala Glu Ala Glu Ala Phe Leu Pro Gly Phe Ser
                165                 170                 175     
Ala Glu Ala Trp Cys Asn Gly Leu Pro Tyr Pro Ser Gln Glu His Gly
            180                 185                 190         
Pro Gln Val Leu Gly Ser Glu Val Lys Val Lys Pro Pro Val Leu Glu
        195                 200                 205             
Ser Gly Ala Gly Met Phe Cys Tyr Gln Pro Pro Leu Gln His Met Tyr
    210                 215                 220                 
Cys Ser Ser Gln Pro Pro Phe His Gln Tyr Ser Pro Gly Gly Gly Ser
225                 230                 235                 240 
Tyr Pro Ile Pro Tyr Leu Gly Ser Ser His Tyr Gln Tyr Gln Arg Met
                245                 250                 255     
Ala Pro Gln Ala Ser Thr Asp Gly His Gln Pro Leu Phe Pro Lys Pro
            260                 265                 270         
Ile Tyr Ser Tyr Ser Ile Leu Ile Phe Met Ala Leu Lys Asn Ser Lys
        275                 280                 285             
Thr Gly Ser Leu Pro Val Ser Glu Ile Tyr Asn Phe Met Thr Glu His
    290                 295                 300                 
Phe Pro Tyr Phe Lys Thr Ala Pro Asp Gly Trp Lys Asn Ser Val Arg
305                 310                 315                 320 
His Asn Leu Ser Leu Asn Lys Cys Phe Glu Lys Val Glu Asn Lys Ser
                325                 330                 335     
Gly Ser Ser Ser Arg Lys Gly Cys Leu Trp Ala Leu Asn Pro Ala Lys
            340                 345                 350         
Ile Asp Lys Met Gln Glu Glu Leu Gln Lys Trp Lys Arg Lys Asp Pro
        355                 360                 365             
Ile Ala Val Arg Lys Ser Met Ala Lys Pro Glu Glu Leu Asp Ser Leu
    370                 375                 380                 
Ile Gly Asp Lys Arg Glu Lys Leu Gly Ser Pro Leu Leu Gly Cys Pro
385                 390                 395                 400 
Pro Pro Gly Leu Ser Gly Ser Gly Pro Ile Arg Pro Leu Ala Pro Pro
                405                 410                 415     
Ala Gly Leu Ser Pro Pro Leu His Ser Leu His Pro Ala Pro Gly Pro
            420                 425                 430         
Ile Pro Gly Lys Asn Pro Leu Gln Asp Leu Leu Met Gly His Thr Pro
        435                 440                 445             
Ser Cys Tyr Gly Gln Thr Tyr Leu His Leu Ser Pro Gly Leu Ala Pro
    450                 455                 460                 
Pro Gly Pro Pro Gln Pro Leu Phe Pro Gln Pro Asp Gly His Leu Glu
465                 470                 475                 480 
Leu Arg Ala Gln Pro Gly Thr Pro Gln Asp Ser Pro Leu Pro Ala His
                485                 490                 495     
Thr Pro Pro Ser His Ser Ala Lys Leu Leu Ala Glu Pro Ser Pro Ala
            500                 505                 510         
Arg Thr Met His Asp Thr Leu Leu Pro Asp Gly Asp Leu Gly Thr Asp
        515                 520                 525             
Leu Asp Ala Ile Asn Pro Ser Leu Thr Asp Phe Asp Phe Gln Gly Asn
    530                 535                 540                 
Leu Trp Glu Gln Leu Lys Asp Asp Ser Leu Ala Leu Asp Pro Leu Val
545                 550                 555                 560 
Leu Val Thr Ser Ser Pro Thr Ser Ser Ser Met Pro Pro Pro Gln Pro
                565                 570                 575     
Pro Pro His Cys Phe Pro Pro Gly Pro Cys Leu Thr Glu Thr Gly Ser
            580                 585                 590         
Gly Ala Gly Asp Leu Ala Ala Pro Gly Ser Gly Gly Ser Gly Ala Leu
        595                 600                 605             
Gly Asp Leu His Leu Thr Thr Leu Tyr Ser Ala Phe Met Glu Leu Glu
    610                 615                 620                 
Pro Thr Pro Pro Thr Ala Pro Ala Gly Pro Ser Val Tyr Leu Ser Pro
625                 630                 635                 640 
Ser Ser Lys Pro Val Ala Leu Ala
                645             


<210> 2691
<211> 374
<212> PRT
<213> Homo sapiens

<400> 2691
Ala Arg Gly Ile Cys Glu Tyr Leu Arg Leu Pro Glu Val Gln Gly Val
 1               5                  10                  15      
Ser Arg Ile Leu Ala His Trp Ala Cys Tyr Lys Val Gln Gln Lys Asp
            20                  25                  30          
Val Ser Asp Glu Asp Val Ala Arg Ala Ile Asn Gln Lys Leu Gly Asp
        35                  40                  45              
Thr Pro Gly Val Ser Tyr Ser Asp Ile Ala Ala Arg Ala Tyr Gly Cys
    50                  55                  60                  
Gly Arg Thr Glu Leu Ala Ile Lys Leu Leu Glu Tyr Glu Pro Arg Ser
65                  70                  75                  80  
Gly Glu Gln Val Pro Leu Leu Leu Lys Met Lys Arg Ser Lys Leu Ala
                85                  90                  95      
Leu Ser Lys Ala Ile Glu Ser Gly Asp Thr Asp Leu Val Phe Thr Val
            100                 105                 110         
Leu Leu His Leu Lys Asn Glu Leu Asn Arg Gly Asp Phe Phe Met Thr
        115                 120                 125             
Leu Arg Asn Gln Pro Met Ala Leu Ser Leu Tyr Arg Gln Phe Cys Lys
    130                 135                 140                 
His Gln Glu Leu Glu Thr Leu Lys Asp Leu Tyr Asn Gln Asp Asp Asn
145                 150                 155                 160 
His Gln Glu Leu Gly Ser Phe His Ile Arg Ala Ser Tyr Ala Ala Glu
                165                 170                 175     
Glu Arg Ile Glu Gly Arg Val Ala Ala Leu Gln Thr Ala Ala Asp Ala
            180                 185                 190         
Phe Tyr Lys Ala Lys Asn Glu Phe Ala Ala Lys Ala Thr Glu Asp Gln
        195                 200                 205             
Met Arg Leu Leu Arg Leu Gln Arg Arg Leu Glu Asp Glu Leu Gly Gly
    210                 215                 220                 
Gln Phe Leu Asp Leu Ser Leu His Asp Thr Val Thr Thr Leu Ile Leu
225                 230                 235                 240 
Gly Gly His Asn Lys Arg Ala Glu Gln Leu Ala Arg Asp Phe Arg Ile
                245                 250                 255     
Pro Asp Lys Arg Leu Trp Trp Leu Lys Leu Thr Ala Leu Ala Asp Leu
            260                 265                 270         
Glu Asp Trp Glu Glu Leu Glu Lys Phe Ser Lys Ser Lys Lys Ser Pro
        275                 280                 285             
Ile Gly Tyr Leu Pro Phe Val Glu Ile Cys Met Lys Gln His Asn Lys
    290                 295                 300                 
Tyr Glu Ala Lys Lys Tyr Ala Ser Arg Val Gly Pro Glu Gln Lys Val
305                 310                 315                 320 
Lys Ala Leu Leu Leu Val Gly Asp Val Ala Gln Ala Ala Asp Val Ala
                325                 330                 335     
Ile Glu His Arg Asn Glu Ala Glu Leu Ser Leu Val Leu Ser His Cys
            340                 345                 350         
Thr Gly Ala Thr Asp Gly Ala Thr Ala Asp Lys Ile Gln Arg Ala Arg
        355                 360                 365             
Ala Gln Ala Gln Lys Lys
    370                 


<210> 2692
<211> 427
<212> PRT
<213> Homo sapiens

<400> 2692
Met Arg Ala Glu Leu Glu Tyr Gly Leu Lys Lys Lys Ser His Gly Leu
 1               5                  10                  15      
Ala Thr Val Arg Met Leu Pro Thr Tyr Val Cys Gly Leu Pro Asp Gly
            20                  25                  30          
Thr Glu Lys Gly Lys Phe Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe
        35                  40                  45              
Arg Val Leu Leu Val Lys Ile Arg Ser Gly Arg Arg Ser Val Arg Met
    50                  55                  60                  
Tyr Asn Lys Ile Phe Ala Ile Pro Leu Glu Ile Met Gln Gly Thr Gly
65                  70                  75                  80  
Glu Glu Leu Phe Asp His Ile Val Gln Cys Ile Ala Asp Phe Leu Asp
                85                  90                  95      
Tyr Met Gly Leu Lys Gly Ala Ser Leu Pro Leu Gly Phe Thr Phe Ser
            100                 105                 110         
Phe Pro Cys Arg Gln Met Ser Ile Asp Lys Gly Thr Leu Ile Gly Trp
        115                 120                 125             
Thr Lys Gly Phe Lys Ala Thr Asp Cys Glu Gly Glu Asp Val Val Asp
    130                 135                 140                 
Met Leu Arg Glu Ala Ile Lys Arg Arg Asn Glu Phe Asp Leu Asp Ile
145                 150                 155                 160 
Val Ala Val Val Asn Asp Thr Val Gly Thr Met Met Thr Cys Gly Tyr
                165                 170                 175     
Glu Asp Pro Asn Cys Glu Ile Gly Leu Ile Ala Gly Thr Gly Ser Asn
            180                 185                 190         
Met Cys Tyr Met Glu Asp Met Arg Asn Ile Glu Met Val Glu Gly Gly
        195                 200                 205             
Glu Gly Lys Met Cys Ile Asn Thr Glu Trp Gly Gly Phe Gly Asp Asn
    210                 215                 220                 
Gly Cys Ile Asp Asp Ile Arg Thr Arg Tyr Asp Thr Glu Val Asp Glu
225                 230                 235                 240 
Gly Ser Leu Asn Pro Gly Lys Gln Arg Tyr Glu Lys Met Thr Ser Gly
                245                 250                 255     
Met Tyr Leu Gly Glu Ile Val Arg Gln Ile Leu Ile Asp Leu Thr Lys
            260                 265                 270         
Gln Gly Leu Leu Phe Arg Gly Gln Ile Ser Glu Arg Leu Arg Thr Arg
        275                 280                 285             
Gly Ile Phe Glu Thr Lys Phe Leu Ser Gln Ile Glu Ser Asp Arg Leu
    290                 295                 300                 
Ala Leu Leu Gln Val Arg Arg Ile Leu Gln Gln Leu Gly Leu Asp Ser
305                 310                 315                 320 
Thr Cys Glu Asp Ser Ile Val Val Lys Glu Val Cys Gly Ala Val Ser
                325                 330                 335     
Arg Arg Ala Ala Gln Leu Cys Gly Ala Gly Leu Ala Ala Ile Val Glu
            340                 345                 350         
Lys Arg Arg Glu Asp Gln Gly Leu Glu His Leu Arg Ile Thr Val Gly
        355                 360                 365             
Val Asp Gly Thr Leu Tyr Lys Leu His Pro His Phe Ser Arg Ile Leu
    370                 375                 380                 
Gln Glu Thr Val Lys Glu Leu Ala Pro Arg Cys Asp Val Thr Phe Met
385                 390                 395                 400 
Leu Ser Glu Asp Gly Ser Gly Lys Gly Ala Ala Leu Ile Thr Ala Val
                405                 410                 415     
Ala Lys Arg Leu Gln Gln Ala Gln Lys Glu Asn
            420                 425         


<210> 2693
<211> 728
<212> PRT
<213> Homo sapiens

<400> 2693
Met Ala Gly Phe Trp Val Gly Thr Ala Pro Leu Val Ala Ala Gly Arg
 1               5                  10                  15      
Arg Gly Arg Trp Pro Pro Gln Gln Leu Met Leu Ser Ala Ala Leu Arg
            20                  25                  30          
Thr Leu Lys His Val Leu Tyr Tyr Ser Arg Gln Cys Leu Met Val Ser
        35                  40                  45              
Arg Asn Leu Gly Ser Val Gly Tyr Asp Pro Asn Glu Lys Thr Phe Asp
    50                  55                  60                  
Lys Ile Leu Val Ala Asn Arg Gly Glu Ile Ala Cys Arg Val Ile Arg
65                  70                  75                  80  
Thr Cys Lys Lys Met Gly Ile Lys Thr Val Ala Ile His Ser Asp Val
                85                  90                  95      
Asp Ala Ser Ser Val His Val Lys Met Ala Asp Glu Ala Val Cys Val
            100                 105                 110         
Gly Pro Ala Pro Thr Ser Lys Ser Tyr Leu Asn Met Asp Ala Ile Met
        115                 120                 125             
Glu Ala Ile Lys Lys Thr Arg Ala Gln Ala Val His Pro Gly Tyr Gly
    130                 135                 140                 
Phe Leu Ser Glu Asn Lys Glu Phe Ala Arg Cys Leu Ala Ala Glu Asp
145                 150                 155                 160 
Val Val Phe Ile Gly Pro Asp Thr His Ala Ile Gln Ala Met Gly Asp
                165                 170                 175     
Lys Ile Glu Ser Lys Leu Leu Ala Lys Lys Ala Glu Val Asn Thr Ile
            180                 185                 190         
Pro Gly Phe Asp Gly Val Val Lys Asp Ala Glu Glu Ala Val Arg Ile
        195                 200                 205             
Ala Arg Glu Ile Gly Tyr Pro Val Met Ile Lys Ala Ser Ala Gly Gly
    210                 215                 220                 
Gly Gly Lys Gly Met Arg Ile Ala Trp Asp Asp Glu Glu Thr Arg Asp
225                 230                 235                 240 
Gly Phe Arg Leu Ser Ser Gln Glu Ala Ala Ser Ser Phe Gly Asp Asp
                245                 250                 255     
Arg Leu Leu Ile Glu Lys Phe Ile Asp Asn Pro Arg His Ile Glu Ile
            260                 265                 270         
Gln Val Leu Gly Asp Lys His Gly Asn Ala Leu Trp Leu Asn Glu Arg
        275                 280                 285             
Glu Cys Ser Ile Gln Arg Arg Asn Gln Lys Val Val Glu Glu Ala Pro
    290                 295                 300                 
Ser Ile Phe Leu Asp Ala Glu Thr Arg Arg Ala Met Gly Glu Gln Ala
305                 310                 315                 320 
Val Ala Leu Ala Arg Ala Val Lys Tyr Ser Ser Ala Gly Thr Val Glu
                325                 330                 335     
Phe Leu Val Asp Ser Lys Lys Asn Phe Tyr Phe Leu Glu Met Asn Thr
            340                 345                 350         
Arg Leu Gln Val Glu His Pro Val Thr Glu Cys Ile Thr Gly Leu Asp
        355                 360                 365             
Leu Val Gln Glu Met Ile Arg Val Ala Lys Gly Tyr Pro Leu Arg His
    370                 375                 380                 
Lys Gln Ala Asp Ile Arg Ile Asn Gly Trp Ala Val Glu Cys Arg Val
385                 390                 395                 400 
Tyr Ala Glu Asp Pro Tyr Lys Ser Phe Gly Leu Pro Ser Ile Gly Arg
                405                 410                 415     
Leu Ser Gln Tyr Gln Glu Pro Leu His Leu Pro Gly Val Arg Val Asp
            420                 425                 430         
Ser Gly Ile Gln Pro Gly Ser Asp Ile Ser Ile Tyr Tyr Asp Pro Met
        435                 440                 445             
Ile Ser Lys Leu Ile Thr Tyr Gly Ser Asp Arg Thr Glu Ala Leu Lys
    450                 455                 460                 
Arg Met Ala Asp Ala Leu Asp Asn Tyr Val Ile Arg Gly Val Thr His
465                 470                 475                 480 
Asn Ile Ala Leu Leu Arg Glu Val Ile Ile Asn Ser Arg Phe Val Lys
                485                 490                 495     
Gly Asp Ile Ser Thr Lys Phe Leu Ser Asp Val Tyr Pro Asp Gly Phe
            500                 505                 510         
Lys Gly His Met Leu Thr Lys Ser Glu Lys Asn Gln Leu Leu Ala Ile
        515                 520                 525             
Ala Ser Ser Leu Phe Val Ala Phe Gln Leu Arg Ala Gln His Phe Gln
    530                 535                 540                 
Glu Asn Ser Arg Met Pro Val Ile Lys Pro Asp Ile Ala Asn Trp Glu
545                 550                 555                 560 
Leu Ser Val Lys Leu His Asp Lys Val His Thr Val Val Ala Ser Asn
                565                 570                 575     
Asn Gly Ser Val Phe Ser Val Glu Val Asp Gly Ser Lys Leu Asn Val
            580                 585                 590         
Thr Ser Thr Trp Asn Leu Ala Ser Pro Leu Leu Ser Val Ser Val Asp
        595                 600                 605             
Gly Thr Gln Arg Thr Val Gln Cys Leu Ser Arg Glu Ala Gly Gly Asn
    610                 615                 620                 
Met Ser Ile Gln Phe Leu Gly Thr Val Tyr Lys Val Asn Ile Leu Thr
625                 630                 635                 640 
Arg Leu Ala Ala Glu Leu Asn Lys Phe Met Leu Glu Lys Val Thr Glu
                645                 650                 655     
Asp Thr Ser Ser Val Leu Arg Ser Pro Met Pro Gly Val Val Val Ala
            660                 665                 670         
Val Ser Val Lys Pro Gly Asp Ala Val Ala Glu Gly Gln Glu Ile Cys
        675                 680                 685             
Val Ile Glu Ala Met Lys Met Gln Asn Ser Met Thr Ala Gly Lys Thr
    690                 695                 700                 
Gly Thr Val Lys Ser Val His Cys Gln Ala Gly Asp Thr Val Gly Glu
705                 710                 715                 720 
Gly Asp Leu Leu Val Glu Leu Glu
                725             


<210> 2694
<211> 587
<212> PRT
<213> Homo sapiens

<400> 2694
Met Thr Arg Phe Ser Tyr Ala Glu Tyr Phe Ser Leu Phe His Ser Cys
 1               5                  10                  15      
Ser Ala Pro Ser Arg Ser Thr Ala Pro Pro Glu Ser Ser Pro Ala Arg
            20                  25                  30          
Ala Pro Met Gly Leu Phe Gln Gly Val Met Gln Lys Tyr Ser Ser Ser
        35                  40                  45              
Leu Phe Lys Thr Ser Gln Leu Ala Pro Ala Asp Pro Leu Ile Lys Ala
    50                  55                  60                  
Ile Lys Asp Gly Asp Glu Glu Ala Leu Lys Thr Met Ile Lys Glu Gly
65                  70                  75                  80  
Lys Asn Leu Ala Glu Pro Asn Lys Glu Gly Trp Leu Pro Leu His Glu
                85                  90                  95      
Ala Ala Tyr Tyr Gly Gln Val Gly Cys Leu Lys Val Leu Gln Arg Ala
            100                 105                 110         
Tyr Pro Gly Thr Ile Asp Gln Arg Thr Leu Gln Glu Glu Thr Ala Val
        115                 120                 125             
Tyr Leu Ala Thr Cys Arg Gly His Leu Asp Cys Leu Leu Ser Leu Leu
    130                 135                 140                 
Gln Ala Gly Ala Glu Pro Asp Ile Ser Asn Lys Ser Arg Glu Thr Pro
145                 150                 155                 160 
Leu Tyr Lys Ala Cys Glu Arg Lys Asn Ala Glu Ala Val Lys Ile Leu
                165                 170                 175     
Val Gln His Asn Ala Asp Thr Asn His Arg Cys Asn Arg Gly Trp Thr
            180                 185                 190         
Ala Leu His Glu Ser Val Ser Arg Asn Asp Leu Glu Val Met Gln Ile
        195                 200                 205             
Leu Val Ser Gly Gly Ala Lys Val Glu Ser Lys Asn Ala Tyr Gly Ile
    210                 215                 220                 
Thr Pro Leu Phe Val Ala Ala Gln Ser Gly Gln Leu Glu Ala Leu Arg
225                 230                 235                 240 
Phe Leu Ala Lys Tyr Gly Ala Asp Ile Asn Thr Gln Ala Ser Asp Asn
                245                 250                 255     
Ala Ser Ala Leu Tyr Glu Ala Cys Lys Asn Glu His Glu Glu Val Val
            260                 265                 270         
Glu Phe Leu Leu Ser Gln Gly Ala Asp Ala Asn Lys Thr Asn Lys Asp
        275                 280                 285             
Gly Leu Leu Pro Leu His Ile Ala Ser Lys Lys Gly Asn Tyr Arg Ile
    290                 295                 300                 
Val Gln Met Leu Leu Pro Val Thr Ser Arg Thr Arg Ile Arg Arg Ser
305                 310                 315                 320 
Gly Val Ser Pro Leu His Leu Ala Ala Glu Arg Asn His Asp Glu Val
                325                 330                 335     
Leu Glu Ala Leu Leu Ser Ala Arg Phe Asp Val Asn Thr Pro Leu Ala
            340                 345                 350         
Pro Glu Arg Ala Arg Leu Tyr Glu Asp Arg Arg Ser Ser Ala Leu Tyr
        355                 360                 365             
Phe Ala Val Val Asn Asn Asn Val Tyr Ala Thr Glu Leu Leu Leu Gln
    370                 375                 380                 
His Gly Ala Asp Pro Asn Arg Asp Val Ile Ser Pro Leu Leu Val Ala
385                 390                 395                 400 
Ile Arg His Gly Cys Leu Arg Thr Met Gln Leu Leu Leu Asp His Gly
                405                 410                 415     
Ala Asn Ile Asp Ala Tyr Ile Ala Thr His Pro Thr Ala Phe Pro Ala
            420                 425                 430         
Thr Ile Met Phe Ala Met Lys Cys Leu Ser Leu Leu Lys Phe Leu Met
        435                 440                 445             
Asp Leu Gly Cys Asp Gly Glu Pro Cys Phe Ser Cys Leu Tyr Gly Asn
    450                 455                 460                 
Gly Pro His Pro Pro Ala Pro Gln Pro Ser Ser Arg Phe Asn Asp Ala
465                 470                 475                 480 
Pro Ala Ala Asp Lys Glu Pro Ser Val Val Gln Phe Cys Glu Phe Val
                485                 490                 495     
Ser Ala Pro Glu Val Ser Arg Trp Ala Gly Pro Ile Ile Asp Val Leu
            500                 505                 510         
Leu Asp Tyr Val Gly Asn Val Gln Leu Cys Ser Arg Leu Lys Glu His
        515                 520                 525             
Ile Asp Ser Phe Glu Asp Trp Ala Val Ile Lys Glu Lys Ala Glu Pro
    530                 535                 540                 
Pro Arg Pro Leu Ala His Leu Cys Arg Leu Arg Val Arg Lys Ala Ile
545                 550                 555                 560 
Gly Lys Tyr Arg Ile Lys Leu Leu Asp Thr Leu Pro Leu Pro Gly Arg
                565                 570                 575     
Leu Ile Arg Tyr Leu Lys Tyr Glu Asn Thr Gln
            580                 585         


<210> 2695
<211> 285
<212> PRT
<213> Homo sapiens

<400> 2695
Asp Arg Leu Asp Leu Leu Cys Pro Arg Ala Arg Pro Pro Gly Pro His
 1               5                  10                  15      
Ser Ser Pro Asn Tyr Glu Phe Tyr Lys Leu Tyr Leu Val Gly Gly Ala
            20                  25                  30          
Gln Gly Arg Arg Cys Glu Ala Pro Pro Ala Pro Asn Leu Leu Leu Thr
        35                  40                  45              
Cys Asp Arg Pro Asp Leu Asp Leu Arg Phe Thr Ile Lys Phe Gln Glu
    50                  55                  60                  
Tyr Ser Pro Asn Leu Trp Gly His Glu Phe Arg Ser His His Asp Tyr
65                  70                  75                  80  
Tyr Ile Ile Ala Thr Ser Asp Gly Thr Arg Glu Gly Leu Glu Ser Leu
                85                  90                  95      
Gln Gly Gly Val Cys Leu Thr Arg Gly Met Lys Val Leu Leu Arg Val
            100                 105                 110         
Gly Gln Ser Pro Arg Gly Gly Ala Val Pro Arg Lys Pro Val Ser Glu
        115                 120                 125             
Met Pro Met Glu Arg Asp Arg Gly Ala Ala His Ser Leu Glu Pro Gly
    130                 135                 140                 
Lys Glu Asn Leu Pro Gly Asp Pro Thr Ser Asn Ala Thr Ser Arg Gly
145                 150                 155                 160 
Ala Glu Gly Pro Leu Pro Pro Pro Ser Met Pro Ala Val Ala Gly Ala
                165                 170                 175     
Ala Gly Gly Leu Ala Leu Leu Leu Leu Gly Val Ala Gly Ala Gly Gly
            180                 185                 190         
Ala Met Cys Trp Arg Arg Arg Arg Ala Lys Pro Ser Glu Ser Arg His
        195                 200                 205             
Pro Gly Pro Gly Ser Phe Gly Arg Gly Gly Ser Leu Gly Leu Gly Gly
    210                 215                 220                 
Gly Gly Gly Met Gly Pro Arg Glu Ala Glu Pro Gly Glu Leu Gly Ile
225                 230                 235                 240 
Ala Leu Arg Gly Gly Gly Ala Ala Asp Pro Pro Phe Cys Pro His Tyr
                245                 250                 255     
Glu Lys Val Ser Gly Asp Tyr Gly His Pro Val Tyr Ile Val Gln Asp
            260                 265                 270         
Gly Pro Pro Gln Ser Pro Pro Asn Ile Tyr Tyr Lys Val
        275                 280                 285 


<210> 2696
<211> 399
<212> PRT
<213> Homo sapiens

<400> 2696
Met Lys Arg Thr His Leu Phe Ile Val Gly Ile Tyr Phe Leu Ser Ser
 1               5                  10                  15      
Cys Arg Ala Glu Glu Gly Leu Asn Phe Pro Thr Tyr Asp Gly Lys Asp
            20                  25                  30          
Arg Val Val Ser Leu Ser Glu Lys Asn Phe Lys Gln Val Leu Lys Lys
        35                  40                  45              
Tyr Asp Leu Leu Cys Leu Tyr Tyr His Glu Pro Val Ser Ser Asp Lys
    50                  55                  60                  
Val Thr Gln Lys Gln Phe Gln Leu Lys Glu Ile Val Leu Glu Leu Val
65                  70                  75                  80  
Ala Gln Val Leu Glu His Lys Ala Ile Gly Phe Val Met Val Asp Ala
                85                  90                  95      
Lys Lys Glu Ala Lys Leu Ala Lys Lys Leu Gly Phe Asp Glu Glu Gly
            100                 105                 110         
Ser Leu Tyr Ile Leu Lys Gly Asp Arg Thr Ile Glu Phe Asp Gly Glu
        115                 120                 125             
Phe Ala Ala Asp Val Leu Val Glu Phe Leu Leu Asp Leu Ile Glu Asp
    130                 135                 140                 
Pro Val Glu Ile Ile Ser Ser Lys Leu Glu Val Gln Ala Phe Glu Arg
145                 150                 155                 160 
Ile Glu Asp Tyr Ile Lys Leu Ile Gly Phe Phe Lys Ser Glu Asp Ser
                165                 170                 175     
Glu Tyr Tyr Lys Ala Phe Glu Glu Ala Ala Glu His Phe Gln Pro Tyr
            180                 185                 190         
Ile Lys Phe Phe Ala Thr Phe Asp Lys Gly Val Ala Lys Lys Leu Ser
        195                 200                 205             
Leu Lys Met Asn Glu Val Asp Phe Tyr Glu Pro Phe Met Asp Glu Pro
    210                 215                 220                 
Ile Ala Ile Pro Asn Lys Pro Tyr Thr Glu Glu Glu Leu Val Glu Phe
225                 230                 235                 240 
Val Lys Glu His Gln Arg Pro Thr Leu Arg Arg Leu Arg Pro Glu Glu
                245                 250                 255     
Met Phe Glu Thr Trp Glu Asp Asp Leu Asn Gly Ile His Ile Val Ala
            260                 265                 270         
Phe Ala Glu Lys Ser Asp Pro Asp Gly Tyr Glu Phe Leu Glu Ile Leu
        275                 280                 285             
Lys Gln Val Ala Arg Asp Asn Thr Asp Asn Pro Asp Leu Ser Ile Leu
    290                 295                 300                 
Trp Ile Asp Pro Asp Asp Phe Pro Leu Leu Val Ala Tyr Trp Glu Lys
305                 310                 315                 320 
Thr Phe Lys Ile Asp Leu Phe Arg Pro Gln Ile Gly Val Val Asn Val
                325                 330                 335     
Thr Asp Ala Asp Ser Val Trp Met Glu Ile Pro Asp Asp Asp Asp Leu
            340                 345                 350         
Pro Thr Ala Glu Glu Leu Glu Asp Trp Ile Glu Asp Val Leu Ser Gly
        355                 360                 365             
Lys Ile Asn Thr Glu Asp Asp Asp Glu Asp Asp Asp Asp Asp Asp Asn
    370                 375                 380                 
Ser Asp Glu Glu Asp Asn Asp Asp Ser Asp Asp Asp Asp Asp Glu
385                 390                 395                 


<210> 2697
<211> 748
<212> PRT
<213> Homo sapiens

<400> 2697
Met Ser Gly Ser Gly Arg Lys Asp Phe Asp Val Lys His Ile Leu Arg
 1               5                  10                  15      
Leu Arg Trp Lys Leu Phe Ser His Pro Ser Pro Ser Thr Gly Gly Pro
            20                  25                  30          
Ala Gly Gly Gly Cys Leu Gln Gln Asp Gly Ser Gly Ser Phe Glu His
        35                  40                  45              
Trp Gly Pro Ser Gln Ser Arg Leu Leu Lys Ser Gln Glu Arg Ser Gly
    50                  55                  60                  
Val Ser Thr Phe Trp Lys Lys Pro Ser Ser Ser Ser Ser Ser Ser Ser
65                  70                  75                  80  
Ser Pro Ser Ser Ser Ser Ser Ser Phe Asn Pro Leu Asn Gly Thr Leu
                85                  90                  95      
Leu Pro Val Ala Thr Arg Leu Gln Gln Gly Ala Pro Gly Gln Gly Thr
            100                 105                 110         
Gln Gln Pro Ala Arg Thr Leu Phe Tyr Val Glu Ser Leu Glu Glu Glu
        115                 120                 125             
Val Val Pro Gly Met Asp Phe Pro Gly Pro His Glu Lys Gly Leu Val
    130                 135                 140                 
Leu Gln Glu Leu Lys Val Glu Pro Asp Asn Ser Ser Gln Ala Thr Gly
145                 150                 155                 160 
Glu Gly Cys Gly His Arg Leu Ser Ser Thr Gly His Ser Met Thr Pro
                165                 170                 175     
Gln Ser Asp Leu Asp Ser Ser Ser Ser Glu Glu Phe Tyr Gln Ala Val
            180                 185                 190         
His His Ala Glu Gln Thr Phe Arg Lys Met Glu Ser Tyr Leu Lys Gln
        195                 200                 205             
Gln Gln Leu Cys Asp Val Ile Leu Ile Val Gly Asn Arg Lys Ile Pro
    210                 215                 220                 
Ala His Arg Leu Val Leu Ser Ser Val Ser Asp Tyr Phe Ala Ala Met
225                 230                 235                 240 
Phe Thr Ser Asp Val Cys Glu Ala Lys Gln Glu Glu Ile Lys Met Glu
                245                 250                 255     
Gly Ile Asp Pro Asn Ala Leu Trp Asp Leu Val Gln Phe Ala Tyr Thr
            260                 265                 270         
Gly Cys Leu Glu Leu Lys Glu Asp Thr Ile Glu Asn Leu Leu Ala Ala
        275                 280                 285             
Ala Cys Leu Leu Gln Leu Pro Gln Val Val Glu Val Cys Cys His Phe
    290                 295                 300                 
Leu Met Lys Leu Leu His Pro Ser Asn Cys Leu Gly Ile Arg Ala Phe
305                 310                 315                 320 
Ala Asp Ala Gln Gly Cys Ile Glu Leu Met Lys Val Ala His Ser Tyr
                325                 330                 335     
Thr Met Glu Asn Ile Met Glu Val Ile Arg Asn Gln Glu Phe Leu Leu
            340                 345                 350         
Leu Pro Ala Glu Glu Leu His Lys Leu Leu Ala Ser Asp Asp Val Asn
        355                 360                 365             
Val Pro Asp Glu Glu Thr Ile Phe His Ala Leu Met Met Trp Val Lys
    370                 375                 380                 
Tyr Asp Met Gln Ser Arg Cys Asn Asp Leu Ser Met Leu Leu Ala Phe
385                 390                 395                 400 
Ile Arg Leu Pro Leu Leu Pro Pro Gln Ile Leu Ala Asp Leu Glu Asn
                405                 410                 415     
His Ala Leu Phe Lys Asn Asp Val Glu Cys Gln Lys Leu Ile Leu Glu
            420                 425                 430         
Ala Met Lys Tyr His Leu Leu Pro Glu Arg Arg Thr Leu Met Gln Ser
        435                 440                 445             
Pro Arg Thr Lys Pro Arg Lys Ser Thr Val Gly Thr Leu Tyr Ala Val
    450                 455                 460                 
Gly Gly Met Asp Asn Asn Lys Gly Ala Thr Thr Ile Glu Lys Tyr Asp
465                 470                 475                 480 
Leu Arg Thr Asn Leu Trp Ile Gln Ala Gly Met Met Asn Gly Arg Arg
                485                 490                 495     
Leu Gln Phe Gly Val Ala Val Ile Asp Asp Lys Leu Phe Val Ile Gly
            500                 505                 510         
Gly Arg Asp Gly Leu Lys Thr Leu Asn Thr Val Glu Cys Tyr Asn Pro
        515                 520                 525             
Lys Thr Lys Thr Trp Thr Val Leu Pro Pro Met Ser Thr His Arg His
    530                 535                 540                 
Gly Leu Gly Val Thr Val Leu Glu Gly Pro Ile Tyr Ala Val Gly Gly
545                 550                 555                 560 
His Asp Gly Trp Ser Tyr Leu Asn Thr Val Glu Arg Trp Asp Pro Gln
                565                 570                 575     
Ser Gln Gln Trp Thr Phe Val Ala Ser Met Ser Ile Ala Arg Ser Thr
            580                 585                 590         
Val Gly Val Ala Ala Leu Asn Gly Lys Leu Tyr Ser Val Gly Gly Arg
        595                 600                 605             
Asp Gly Ser Ser Cys Leu Ser Ser Met Glu Tyr Tyr Asp Pro His Thr
    610                 615                 620                 
Asn Lys Trp Asn Met Cys Ala Pro Met Cys Lys Arg Arg Gly Gly Val
625                 630                 635                 640 
Gly Val Ala Thr Cys Asp Gly Phe Leu Tyr Ala Val Gly Gly His Asp
                645                 650                 655     
Ala Pro Ala Ser Asn His Cys Ser Arg Leu Leu Asp Tyr Val Glu Arg
            660                 665                 670         
Tyr Asp Pro Lys Thr Asp Thr Trp Thr Met Val Ala Pro Leu Ser Met
        675                 680                 685             
Pro Arg Asp Ala Val Gly Val Cys Leu Leu Gly Asp Arg Leu Tyr Ala
    690                 695                 700                 
Val Gly Gly Tyr Asp Gly Gln Thr Tyr Leu Asn Thr Met Glu Ser Tyr
705                 710                 715                 720 
Asp Pro Gln Thr Asn Glu Trp Thr Gln Met Ala Ser Leu Asn Ile Gly
                725                 730                 735     
Arg Ala Gly Ala Cys Val Val Val Ile Lys Gln Pro
            740                 745             


<210> 2698
<211> 209
<212> PRT
<213> Homo sapiens

<400> 2698
Pro Ala Arg Tyr Pro Leu Pro Ala Ser Ala Val Pro Thr Ala Gly Leu
 1               5                  10                  15      
Arg Ala Thr Arg Pro Gln Arg Ala Ser His Met Glu Ala Pro Glu Glu
            20                  25                  30          
Pro Ala Pro Val Arg Gly Gly Pro Glu Ala Thr Leu Glu Val Arg Gly
        35                  40                  45              
Ser Arg Cys Leu Arg Leu Ser Ala Phe Arg Glu Glu Leu Arg Ala Leu
    50                  55                  60                  
Leu Val Leu Ala Gly Pro Ala Val Ser Lys Val Ala Ser Val Ala Gly
65                  70                  75                  80  
Arg Tyr Arg Arg Ala Gly Asp Leu Val Ile Ser Ala Ser Ala Gly Asp
                85                  90                  95      
Phe Gly Gly Leu Trp Gly Pro Ser Glu Leu Ser Ala Gly Gly Leu Arg
            100                 105                 110         
Gly Ala Ser Cys Gln Glu Pro Gly Gly His Pro Ser Ser Ser Ala Cys
        115                 120                 125             
Val Pro Ala Ala Phe Arg Ser Ala Pro Pro Asp Trp Gly Pro Arg Gly
    130                 135                 140                 
Ala Leu Arg Glu Arg Leu Val Arg Ala Arg Ala His Val Gly Ser Glu
145                 150                 155                 160 
Arg Pro Ala Ala Pro Ala Ser Cys Ala Arg Arg His Arg Arg Ala Gly
                165                 170                 175     
Thr Phe Ala Pro Asn Gly Ala Leu Pro Gly Pro Gly Cys Ile Cys Ile
            180                 185                 190         
Arg Gly Cys Leu Leu Trp Glu Leu Ile Pro Ala Asn Lys Thr Gln Val
        195                 200                 205             
Ala
    


<210> 2699
<211> 1688
<212> PRT
<213> Homo sapiens

<400> 2699
Met Ser Asp Ile Asn Thr Leu Ser Asn Trp Phe Gln Thr Gln Lys His
 1               5                  10                  15      
Val Arg Arg Asn Gly Thr Gln Pro Tyr Ser Gln Thr Val Thr Thr Trp
            20                  25                  30          
Met Lys Pro Glu Arg Met Ile Met Asp Leu Tyr Ser Glu Ile His Pro
        35                  40                  45              
Trp Thr His Pro Glu Ala Asn Pro Val Ile Arg Tyr Trp Phe Gln Thr
    50                  55                  60                  
Gln Met Asn Ser Ile Arg Ser Trp Asn Gln Ser Glu Thr Glu Val Phe
65                  70                  75                  80  
Gln Ile Trp Thr Thr Gln Cys Asp Thr Val Arg Pro Trp Ile His Pro
                85                  90                  95      
Glu Ser Leu Ser Leu Val Gln Thr Glu Val Gly Ile Phe Trp Pro Trp
            100                 105                 110         
Thr Gln Gln Arg Ala Ala Thr Tyr Arg Thr Asn Ala Glu Asn Gln Ala
        115                 120                 125             
Pro Glu Val Asp Ile Ile His Ala Leu Ile Arg Ser Glu Ser Phe Leu
    130                 135                 140                 
Leu Ser Phe Trp Pro Lys Val Leu Ser Pro Val Val Lys Pro Trp Thr
145                 150                 155                 160 
Leu Leu Ile Gly Arg Thr Leu Ile Ser Trp Ile Leu Pro Val Ala Lys
                165                 170                 175     
Ala Asp Met His Trp Ile Gln Ser Glu Ala Asp Ile Ile Glu Cys Phe
            180                 185                 190         
Ala Val Phe Lys Ala Val Ser Ala Ser Lys Asp Ala Leu Thr Phe Ile
        195                 200                 205             
Ser Ala Pro Thr Ser Ile Trp Pro His Phe Ile Ser Leu Pro Gln Pro
    210                 215                 220                 
Gln Ser Lys Ala Gln Asn Leu Ala Ser Ala Asp Gln Ile Ser Leu Gln
225                 230                 235                 240 
Tyr Ala Met Pro Trp Gln Ala Gly Ile Ile Ser Cys Gly Ser Gln Val
                245                 250                 255     
Tyr Ser Gly Ser Ile Val Ser Ser Ser Trp Val Leu Ile Ala Ala His
            260                 265                 270         
Cys Val Arg Asn Met Ser Thr Ser Gly Val Pro Asn Asn Leu His Leu
        275                 280                 285             
Val Lys Glu Ser Pro Asp Asp Ser Val Gly Lys Pro Pro Asp Ala Cys
    290                 295                 300                 
Asn Ser Ala Arg Ala Gln Arg Met Trp Ser Arg Asp Ile Ser Gln Thr
305                 310                 315                 320 
Phe Gly Leu Ser Arg Ser Asp Val Asp Pro Leu Phe Leu Ser Ala Pro
                325                 330                 335     
Met Pro Pro Arg Ser Pro Met Pro Ile Pro Cys Cys Gln Pro Ser Gly
            340                 345                 350         
Ile Gly Ser Cys Lys Asp Met Ala Leu Ser Gln Lys Pro Arg Pro Gln
        355                 360                 365             
Gly His Ser Arg Ser Leu Pro Pro Ser Glu Gly Pro Pro Ala Ser Pro
    370                 375                 380                 
Leu Met Ala Trp Met Ala Ala Leu Ala Val Gly Leu Arg Thr Thr Ala
385                 390                 395                 400 
Gly Ser Thr Ala His Arg Ser Ser Glu Ala Arg Gly Arg Gly Pro Val
                405                 410                 415     
Leu Ala Glu Pro His Gln Gln Ala Pro Gln Arg Leu Leu Arg Val Arg
            420                 425                 430         
Glu Pro Leu Gly Arg Gln Gly Ser Ala Gln Gln Arg Ala Arg Arg Pro
        435                 440                 445             
Thr Met Ala Asn Pro Gly Gly Trp Pro Leu Val Cys Pro Gly His Arg
    450                 455                 460                 
Thr Arg Gly Pro Leu Glu Cys Ser Leu Glu Tyr Ser Ile Leu Arg Glu
465                 470                 475                 480 
Glu Ala Trp Met Glu Ala Val Gln Glu Gly Ala Ala Gly Val Glu Ser
                485                 490                 495     
Glu Gln Ala Ala Leu Arg Glu Glu Ala Val Gln Leu Leu Asp Asp Ile
            500                 505                 510         
Met Ala Glu Val Glu Val Val Ala Gln Glu Glu Ala Leu Val Glu Gly
        515                 520                 525             
Gln Glu Glu Ala Gln Lys Pro Gln Pro Gly Pro Gly Pro Ile Ile Pro
    530                 535                 540                 
Glu Ser Ala Leu Glu Glu Leu Val Ala Val Gln Gly Lys Asp Gly Met
545                 550                 555                 560 
Glu Ala Gln Ala Pro Pro Arg Pro Gln Arg Arg Arg His Pro Glu Arg
                565                 570                 575     
Pro Trp Leu Leu Gly Pro Cys Cys Ile Leu Leu Ser Val Phe Ser Ala
            580                 585                 590         
Phe Pro Val Glu Arg Cys Ser Arg Gly Ser Val Ser Asp Arg Trp Ala
        595                 600                 605             
Ala His Arg Arg Tyr Asp Ser Leu Glu Asn Lys Gly Glu Leu Pro Arg
    610                 615                 620                 
Thr Asn Glu Ala Val Glu Ser Arg Ser Arg Arg Gly Tyr Cys Phe Pro
625                 630                 635                 640 
Ala Cys Gly Arg Glu Thr Leu Gly Asp Ala Glu Gln Gln Thr Phe Gly
                645                 650                 655     
Ala Ser Phe Glu Glu Gln Lys Arg Val Gln Thr Arg Ile Arg Phe Ser
            660                 665                 670         
Val Asn Glu Ala Tyr Arg Ala Tyr Ser Thr Pro Ile Gln Gln Tyr Gln
        675                 680                 685             
Asp Tyr Asp Val Glu Pro Tyr Arg Trp Gly His His Asn Ser Ser Leu
    690                 695                 700                 
Asn Phe Phe Asn Trp Phe Ala Asp Arg Asn Phe Thr Gly Ser Asn Arg
705                 710                 715                 720 
Ile Ala Glu Glu Ser Pro His Trp Glu Thr Leu Gly Met Thr Leu Ser
                725                 730                 735     
Leu Cys Thr Glu Leu Trp His Lys Pro Leu Gln Tyr Tyr Met Lys Met
            740                 745                 750         
Lys Pro Pro Glu Glu Gly Thr Glu Ile Ser Asp Glu Pro Leu Ser Trp
        755                 760                 765             
Asn Trp Ser Tyr Leu Val Pro Arg Pro Pro His Leu Ser Asn Pro Ala
    770                 775                 780                 
Ile Pro Trp Thr Val Thr Val Asn Gln Pro Thr Glu Glu Ala Gln Leu
785                 790                 795                 800 
Gly Ser Ala Leu Pro Glu Thr Gly Ala Phe Thr Cys Met Thr Leu Glu
                805                 810                 815     
Pro Leu Asp Cys Ser Gly Ala Ser Cys Pro Val Ser Trp Arg Glu Arg
            820                 825                 830         
Ile Gln Lys Gly Ser Cys Gln Ala Gln Leu Pro Thr Tyr His Ser Leu
        835                 840                 845             
Tyr His Ala Gly Arg Arg Ser Ser Leu Gln Met Pro Met Gln Tyr Ser
    850                 855                 860                 
Leu Val Ile Thr Ser Met Gln Lys Gln Cys Pro Ser Pro Asp Ser His
865                 870                 875                 880 
Arg Pro Pro Pro Val Leu Pro Asp Pro His His Arg Asn Pro Ala Ala
                885                 890                 895     
Ala Leu Thr Gly Ala Cys Gly Ser Glu Gly Pro Gln Gly Ala Cys Thr
            900                 905                 910         
Gly Leu Gln Ala Pro Pro Thr Asp Phe Arg Gln Thr Ala Pro Gly Ala
        915                 920                 925             
Ala Pro Thr Pro Pro Ala Ser Pro Arg Gly Gln Ser Val Gly Gly Arg
    930                 935                 940                 
Trp Ala Ser Pro Trp Ala Ala Pro Thr Gln Ala His Arg Arg Pro Ala
945                 950                 955                 960 
Ala Arg Leu Ala Val Asp Ile Leu Arg Ala His Asn Cys Thr Leu Pro
                965                 970                 975     
Cys Arg Pro Arg Gly Ser Arg Thr Cys Ser Ser Gly Cys Gly Ala Cys
            980                 985                 990         
Trp Trp Gly Ser Ala Ser Pro Arg Pro Trp Ala Val Ala Pro Glu Leu
        995                 1000                1005            
Leu Cys Ala Val Asp Pro Ala Gly Asp Leu Ser Pro Arg Ser Ser Ala
    1010                1015                1020                
Ala Ile Cys Gly Pro Ser Arg Ala Phe Gln Glu Thr Cys Val Tyr Val
1025                1030                1035                1040
Pro Val Gly Leu Gly Ser Gln Gln Gly Glu Val Cys Gly Pro Ser Gly
                1045                1050                1055    
Glu Arg Ala Ser Trp Gly Ala Ala Pro Glu Pro Ser Gly Ala Gly Asp
            1060                1065                1070        
Gly Leu Gly Cys Thr Asp Arg Gly Leu Arg Glu Tyr Pro Gly Gly His
        1075                1080                1085            
Ser Val Gln Ala Gly Gly Ser Ala Gly Glu Asp Gly Pro Val Pro Val
    1090                1095                1100                
Ser Thr Arg Leu Thr Pro Glu Thr Gln Gly Ala Lys Asp Ser Ser Leu
1105                1110                1115                1120
Trp Cys Met Gly Leu Leu Thr Ser Ser Arg Gln Pro Lys Pro Pro Ala
                1125                1130                1135    
His Ser Phe Cys Phe Leu Ser Leu Val Ser Ala Gly Gln Leu Gly Leu
            1140                1145                1150        
Ala Pro Pro Asn Gln Lys Pro Pro Gln Ser Trp Cys Cys Leu Leu Ala
        1155                1160                1165            
Lys Asp Arg Gly Ser Thr Arg Glu Gly Asp Arg Pro Asn Val Trp Lys
    1170                1175                1180                
Ile Ala Leu Leu His Ile Leu Cys Asp Leu Ala Lys Leu Gln Gly Val
1185                1190                1195                1200
Thr Thr Leu Ala Gln Pro Ile Ile Trp Arg Leu Leu Asp Gln Arg Gln
                1205                1210                1215    
Val Glu Glu Leu Ser His Pro Gly Tyr Arg Arg Leu Asp Glu Ile Ser
            1220                1225                1230        
Phe His His Asn Leu Tyr Phe His Asn Glu Val Ile Ile Lys Glu Tyr
        1235                1240                1245            
Phe Phe Gly Ile Leu Gly Tyr Arg Val Ser His Ser Thr Ala Val Gln
    1250                1255                1260                
Trp Asp His Glu Gly Gln Ala Ser Ser Cys Arg Gln Asn Ile Ala Tyr
1265                1270                1275                1280
Leu Ser Leu Phe Ser Cys Leu Ala Glu Tyr Asp Cys Leu Gly Phe Gly
                1285                1290                1295    
Arg Ile Ala Glu Ser Lys Phe Gly Lys Leu Gln Phe Gln Val Gly Ser
            1300                1305                1310        
Arg Ile Leu Leu Asn Ser Phe Glu Ser Gly Thr Gly Ile Leu Ser Leu
        1315                1320                1325            
Tyr Cys Leu Gln Gly Gly Ser Arg Asp Glu Phe Gln Thr Phe Val His
    1330                1335                1340                
Val Val Thr Val Ser Ala Asn Ile Leu Val Gln Glu Phe Thr Ile Gly
1345                1350                1355                1360
Val Ser Val Trp Val His Ser Gly Thr Val Gly Gly Arg Arg Arg Pro
                1365                1370                1375    
Pro Pro Ser Ser Arg Asn Arg Ser Pro Ser Ala Asn Leu Arg Ser Ala
            1380                1385                1390        
Arg Gly Ser Ser Gly Gly Lys Arg Ala Trp Leu Pro Ser His Glu Glu
        1395                1400                1405            
His Leu Gly Asn Val Leu Lys Tyr Lys Gly Gly Thr Met Gly Leu Lys
    1410                1415                1420                
Glu Asn Lys Phe Glu Val Lys Ser Gly Pro Pro Ser Arg Ser Gly Gly
1425                1430                1435                1440
Pro Pro Pro Thr Lys Ser Ala Pro Ala Val Ala Arg Ser Ser Ser Trp
                1445                1450                1455    
Met Gly Gly Gln Glu Val Glu Asn Leu Lys Phe Val Ala Tyr Thr Tyr
            1460                1465                1470        
Ala His Ser Asn His Pro Gly Ser Ser Glu Ser Arg Asp Tyr Ala Pro
        1475                1480                1485            
Pro Ser Arg Asp Tyr Ala Tyr Arg Asp Tyr Gly His Ser Ser Gln Asp
    1490                1495                1500                
Glu His Ser Ser Thr Gly Asn Arg Ser Ile Leu Ile Val Thr Gly Leu
1505                1510                1515                1520
Leu Gln Trp Val Val Ala Gly Trp Asp Cys Leu Ser Pro Gln Ile Phe
                1525                1530                1535    
Trp Leu Gln Glu Val Ser Glu Gly Lys Lys Asp Phe Gly Tyr Asp Ser
            1540                1545                1550        
Ile Thr Gln Arg Thr Leu Ser Asn Thr Pro Asp Tyr Ile Ser Ile Ser
        1555                1560                1565            
Met Arg Pro Asp Ser Gly Thr Gln Leu Leu Arg Ile Gly Val Arg Arg
    1570                1575                1580                
Ala Val Ser Ser Asp Asp Leu Thr Val Thr Lys Gly Leu Ser Phe Gln
1585                1590                1595                1600
Gln Tyr Pro Thr Thr Lys Thr Ala Arg Arg Ile Ala Glu Gly Leu Ser
                1605                1610                1615    
Gly Lys Arg Arg Asn His Asn Lys Gly Lys Ser Arg Val Glu Gln Cys
            1620                1625                1630        
Ser His Thr Ser Asn Cys Val Leu Met Gly Ala Asp Glu Val Glu Lys
        1635                1640                1645            
Phe Ser Gln Arg Leu Ser Val Val Ile Thr Ser Leu Lys Asn Ala Asn
    1650                1655                1660                
Ile Val Val Glu Gly Gln Cys Gly Pro Ser Met Lys Ala Lys Ile Asn
1665                1670                1675                1680
Gln Gly Ser Pro Asp Arg Met Ser
                1685            


<210> 2700
<211> 112
<212> PRT
<213> Homo sapiens

<400> 2700
Met Glu Pro Glu Cys Val Ile Glu Ser Asn Trp Asn Glu Ile Val Asp
 1               5                  10                  15      
Ser Phe Asp Asp Met Asn Leu Ser Glu Ser Leu Leu Arg Asp Ile Tyr
            20                  25                  30          
Ala Tyr Gly Phe Glu Lys Pro Ser Ala Ile Gln Gln Gln Ala Ile Leu
        35                  40                  45              
Pro Cys Ile Arg Gly Tyr Asn Val Ile Ala Gln Ala Arg Ser Gly Thr
    50                  55                  60                  
Gly Lys Met Ala Thr Phe Ala Ile Ser Ile Leu Gln Gln Ile Glu Leu
65                  70                  75                  80  
Asp Leu Lys Ala Thr Gln Ala Leu Val Leu Ala Pro Thr Ser Arg Leu
                85                  90                  95      
His Gly Cys Leu Leu Ser Cys Leu Cys Gln Gly His Gln Tyr Ala Cys
            100                 105                 110         


<210> 2701
<211> 366
<212> PRT
<213> Homo sapiens

<400> 2701
Met Glu Glu Cys Ser Gly Met Leu Asn Gly Gln Asp Arg Pro Lys His
 1               5                  10                  15      
Arg Ala Lys Ala Ala Gln Pro Pro Ile Ser Gln Asn Gly Ser Arg Glu
            20                  25                  30          
Phe Asn Arg Thr Pro Gly Lys Val Thr Gly Ser Ser Ser Glu Ser Phe
        35                  40                  45              
Ser Ser Ser Arg Ile Ile Glu Gln Ser Ala Leu Gly Asp Val Gln His
    50                  55                  60                  
Phe Pro Ile Ser Ile Leu Phe Gly Leu Met Asp Glu Glu Asn Gly Asp
65                  70                  75                  80  
Gly Gln Leu Ser Leu Leu Ser Lys Tyr Glu Val Pro Ser Val Arg Gly
                85                  90                  95      
Leu Thr Leu Ala Phe Ser Gly Ala Asn Val His Glu His Thr Thr Val
            100                 105                 110         
Glu His Gly Leu Leu Arg Ile Trp Ala Leu Glu Ser Glu Arg Lys Asn
        115                 120                 125             
Pro Thr Arg Val Glu Gly Gly Arg Gly Thr Ser Ala Gln Arg Ser Ser
    130                 135                 140                 
Ala Arg Pro Ser Leu Cys Gly Lys Gln Lys Ile Glu Arg Arg Gly Gln
145                 150                 155                 160 
Ser Val Pro Phe Pro Glu Val Arg Gly Thr Asn Met Asp Gln Asp Val
                165                 170                 175     
Pro Gly Val Leu Leu Gly Asn Ala Asp Asp Ile Ala Lys Phe Ser Gln
            180                 185                 190         
Gly Phe Cys His Ser Pro Asn Phe Ile Ser Val Leu Phe Val Asp Ser
        195                 200                 205             
Lys Ser Gln Ala Leu Leu Arg Thr Thr Ala Asp Val Gly Asp Pro Lys
    210                 215                 220                 
Ile Asp Ser Phe Pro Leu Ser Asp His Thr Leu Gln Trp Arg Arg Ala
225                 230                 235                 240 
Gln Pro Gly Ser Leu Ala Asp His Arg Leu Pro Leu Phe Cys Trp Ser
                245                 250                 255     
Trp Cys Leu Ser Pro Glu Arg Gly Arg Phe Leu Lys Gly Ala Ser Trp
            260                 265                 270         
Val Leu Ser Lys Leu Asn Ser Met Gly Gly Ala His Met Ala Leu Val
        275                 280                 285             
Gln Gln Glu Trp Leu Ser Asp Arg Asp Gly Leu Trp Glu Thr Gln Met
    290                 295                 300                 
Gly Lys Glu Tyr Gly Ala Ala Pro Asp Ala Ser Pro Arg Gln Leu Pro
305                 310                 315                 320 
Val Asn Ile Pro Leu Pro His Ile Tyr Glu Ser Cys Pro Thr Leu Gln
                325                 330                 335     
Glu Ala Phe Leu Tyr Ala Arg Glu Asp Tyr Cys Tyr Pro Gly Asn His
            340                 345                 350         
Arg Ala Ser Lys Ile Gln Trp Cys Thr Phe Val Val Ser Ser
        355                 360                 365     


<210> 2702
<211> 289
<212> PRT
<213> Homo sapiens

<400> 2702
Met Pro Trp Ala Gly Pro Asn Gly Ala Asp Gly Ser Thr Gly Arg Gly
 1               5                  10                  15      
Ala Gly Pro Pro Asp Thr Pro Ser Arg Ala Pro Thr Pro Cys Arg Arg
            20                  25                  30          
Arg Ala Ala Pro Thr Cys Ala Leu Pro Asp Pro Ala Arg Ser Ala Pro
        35                  40                  45              
Thr Arg Thr Leu Val Pro Glu Lys Ala Leu Val Ser Leu Ile Ala Val
    50                  55                  60                  
His Pro Ser Ile Val Ser Pro Leu Gly Lys Gln Leu Leu Pro Lys Thr
65                  70                  75                  80  
Phe Gly Gln Ser Asn Val Asn Val Val Pro Gln Val Val Thr Gly Thr
                85                  90                  95      
Pro Gln Arg Pro Ala Ala Ser Asn Thr Leu Val Ile Glu Thr Tyr Ser
            100                 105                 110         
Thr Ala Asn Cys Leu Gln Glu Pro Gly Glu Glu Arg Asn Gln His Ala
        115                 120                 125             
Glu Gln Gln Ala Ser Arg Pro Thr Thr Pro Ser Trp Leu Ile His Leu
    130                 135                 140                 
Pro Phe Ile Ile Val Asn Thr Ser Lys Thr Val Ile Asp Cys Ser Ser
145                 150                 155                 160 
Ile Ser Asn Asp Lys Phe Glu Tyr Leu Phe Asn Phe Asp Asn Thr Ser
                165                 170                 175     
Glu Ile Tyr Asn Asp Ile Glu Val Leu Lys Arg Met Ser Met Ala Cys
            180                 185                 190         
Gly Leu Glu Ser Gly Ser Cys Ser Ala Glu Asp Leu Lys Met Ala Arg
        195                 200                 205             
Ser Leu Val Pro Lys Ala Leu Glu Pro Tyr Val Thr Glu Met Ala Gln
    210                 215                 220                 
Gly Thr Gly Gly Gly Val Phe Ile Thr Thr Ala Arg Ser Met Ser Asn
225                 230                 235                 240 
Gly Lys Lys Leu Ser Ala Ser Asp Leu Thr Asn Asp Thr Gly His Lys
                245                 250                 255     
Leu Gln Pro Gln Tyr Asn Gly Ser Arg Val Glu Thr Pro Val Ser Tyr
            260                 265                 270         
Val Gly Lys Asp Asp Glu Glu Asp Asp Phe Asn Glu Asn Asn Lys Asp
        275                 280                 285             
Asp
    


<210> 2703
<211> 459
<212> PRT
<213> Homo sapiens

<400> 2703
Met Ala Val Val Lys Asn Lys Cys Leu Met Lys Gly Gly Lys Lys Gly
 1               5                  10                  15      
Val Lys Lys Lys Ile Ile Asp Pro Phe Ser Lys Lys Asp Gln Lys Tyr
            20                  25                  30          
Trp Lys Asp Leu Val Thr Arg Thr Gln Gly Thr Gln Ile Ala Ser Asp
        35                  40                  45              
Gly Leu Lys Gly Leu Val Phe Glu Val Ser Leu Ala Asp Val Gln Asn
    50                  55                  60                  
Asp Glu Val Ala Phe Arg Lys Leu Lys Leu Ile Thr Glu Asp Val Gln
65                  70                  75                  80  
Gly Lys Asn Cys Leu Thr Asn Phe Tyr Gly Met Gly Leu Ser Cys Asp
                85                  90                  95      
Lys Ile Cys Ser Met Phe Glu Asn Cys Ser Thr Met Ile Glu Ala His
            100                 105                 110         
Val Asp Val Lys Thr Thr Asp Asp Asn Ile Gly Lys Asp Val Glu Lys
        115                 120                 125             
Ala Cys Gln Phe Ile Leu Ser Met Met Ser Ser Leu Glu Lys Gly Arg
    130                 135                 140                 
Glu Phe Gln His His Phe Trp Pro Leu Lys Lys Ala Ala Thr Ile Arg
145                 150                 155                 160 
Met Ser Ser Pro His Val Thr Ile Ser Arg Asp Ser Lys Glu Glu Gly
                165                 170                 175     
Glu Ile Thr Gln Arg Phe Ala Asn Thr Phe Tyr Cys Val Phe Asn Val
            180                 185                 190         
Pro Val Asn Ala Pro Leu Arg Phe Leu Ser Leu Pro Ser Thr Gln Ser
        195                 200                 205             
Leu Glu Ala Lys Leu Thr Asp Ser Ser Asp Ser Glu Leu Leu Arg Asp
    210                 215                 220                 
Ile Leu Gln Lys Thr Val Lys His Pro Val Cys Val Thr His Pro Pro
225                 230                 235                 240 
Ser Val Lys Tyr Ala Arg Cys Phe Leu Ser Glu Leu Ile Lys Lys His
                245                 250                 255     
Glu Ala Val His Thr Glu Pro Leu Asp Glu Leu Tyr Glu Val Leu Val
            260                 265                 270         
Glu Thr Leu Met Ala Lys Glu Ser Thr Gln Gly His Trp Ser Tyr Leu
        275                 280                 285             
Leu Asp Cys Pro Arg Ala Trp Gln Trp Cys Trp Pro His Ser Pro Gly
    290                 295                 300                 
His Leu Gln Asp Val Pro Pro Pro Gly Ile His Leu Gln Arg Leu Ser
305                 310                 315                 320 
Gln Pro Gly Pro Gln Thr Ala Pro Arg Glu Cys Pro Ser Gln Trp Pro
                325                 330                 335     
Leu Ile Arg Gly Arg His His Cys Gln Leu Ser Pro Arg Val Thr Val
            340                 345                 350         
Ala Gln Leu Asp Trp Asp Ile Ala Met Val His Gln Leu Ser Ala Ile
        355                 360                 365             
Gln Pro Asp Val Val Ile Ala Ala Asp Val Leu Tyr Cys Pro Glu Ala
    370                 375                 380                 
Ile Val Leu Leu Val Gly Val Leu Leu Arg Leu Ala Ala Cys Arg Glu
385                 390                 395                 400 
His Gln Arg Ala Pro Glu Val Tyr Val Ala Phe Thr Val Arg Asn Pro
                405                 410                 415     
Glu Thr Cys Gln Leu Phe Thr Thr Glu Leu Gly Gln Ala Arg Ile Arg
            420                 425                 430         
Trp Glu Val Glu Pro Arg His Asp Gln Lys Leu Phe Pro Tyr Glu Glu
        435                 440                 445             
His Leu Glu Met Ala Met Leu Asn Leu Thr Leu
    450                 455                 


<210> 2704
<211> 118
<212> PRT
<213> Homo sapiens

<400> 2704
Met Met Leu Leu Ser Ser Tyr Ser Arg Met Leu Met Val Ser Asn Ala
 1               5                  10                  15      
His Val Leu Ser Ala Arg Arg Pro Asp Leu Arg Asp Ile Ile Thr Arg
            20                  25                  30          
His Ala Ser Gly Val Pro Met Ser Phe Ile Val Ser Arg Leu Leu Cys
        35                  40                  45              
Phe Asn Thr Gly Cys Val Ala Ser Thr Glu Pro Gly Gly Lys Val Ile
    50                  55                  60                  
Ser Arg Arg Ile Met Gly Gly Cys Thr Gly Ala Gly Ala Met Cys Glu
65                  70                  75                  80  
Ala Gly Thr Gly Gly Pro Ala Phe Cys Ile Phe Ile Pro Glu Cys Arg
                85                  90                  95      
Asn Gly Asp Leu Leu Gly Glu Val Arg Phe Ser Ile Gly Arg Gly Arg
            100                 105                 110         
Gly Ala Gly Leu Asp Thr
        115             


<210> 2705
<211> 413
<212> PRT
<213> Homo sapiens

<400> 2705
Met Pro Phe Arg Val Gly Gln Ala Lys Leu Thr Gly Glu Val Gly Glu
 1               5                  10                  15      
Gly Thr Gly Ala Arg Ser Ser Ala Phe His Ile Ala Ile Gln Leu Ser
            20                  25                  30          
Ser Trp His Gln Val Leu Gln Val Glu Leu Gln Ile Met Pro Lys His
        35                  40                  45              
Glu Gln Gly Pro Leu Lys Ile Gly Gly Arg Lys Glu Val Glu Arg Gln
    50                  55                  60                  
Lys Thr Phe Val Thr Glu Ser Leu Lys Glu Arg Asn Leu Ile Ile Trp
65                  70                  75                  80  
Glu Leu Arg Glu Ala Lys Glu Thr His Pro Gln Pro Leu Arg Leu Ser
                85                  90                  95      
Leu Leu Pro Leu Ser Ile Glu Phe Leu Ser Met Val Val Val Val Val
            100                 105                 110         
Val Arg Ala Glu Thr Glu Leu Arg Ile Asn Gly Lys Lys Pro Ser Lys
        115                 120                 125             
Glu Phe Ile Val Val Met Arg Lys Leu Arg Pro Lys Thr Thr Gln Ser
    130                 135                 140                 
Ala Arg Leu Glu Leu Asp Pro Lys Ser Tyr Ala Ser Leu Cys Tyr Pro
145                 150                 155                 160 
Met Arg Glu Gln Leu Gln Val Met Asn Thr Arg Pro Ser Cys Ser Ile
                165                 170                 175     
Met Ala Phe Lys Leu Ser Gly Ser Asp Ser Met Phe Thr Ile Ala Leu
            180                 185                 190         
Thr Cys Glu Glu Arg Arg Gly Cys Val Glu Glu Gln Gly Pro Cys Trp
        195                 200                 205             
His Gln Glu Thr Ile Ala Asn Asn Arg Asn Pro Val Ser Met Ser Val
    210                 215                 220                 
Lys Asn Pro Gln Pro Pro Tyr Leu Leu Phe Tyr Glu Phe Arg Ser Thr
225                 230                 235                 240 
Leu Ile Asn Gln Asn Met Lys Ala Val Ser Ser Val Ala Arg Gln Ser
                245                 250                 255     
Arg Leu Pro Met Glu Gly Glu Ala Val Thr Lys Val Lys Ile Met Ala
            260                 265                 270         
Val Thr Glu Val Ile Tyr Ser Ala Glu Ser Pro Thr His Asn His Trp
        275                 280                 285             
Ala Ser His Gly Phe Lys Val Ile Ile Gln Val Lys Asp Ser Pro Glu
    290                 295                 300                 
Cys Gly His Thr Leu Ile Phe Leu Glu Ile Cys Leu Arg Asp Leu Arg
305                 310                 315                 320 
Thr Ser Phe Leu Asp Trp Val Lys Trp Val Lys Phe Ile Ile His Met
                325                 330                 335     
Ala Pro Thr Arg Val Pro Thr Lys Thr Ser Leu Ser Val Cys Leu Leu
            340                 345                 350         
Lys Ala Met Ser Gly Pro Thr Gln Arg Gln Leu Gln Glu Ser Val Lys
        355                 360                 365             
His Asp Ala Ser Ser Pro Glu Asp Asn Ala Tyr Ile Thr Asp Tyr Tyr
    370                 375                 380                 
Asp Leu Arg Val Ser Thr Cys Ser Pro Gly Ile Lys Asn Thr Asn Asn
385                 390                 395                 400 
Leu Ser Pro Ile Phe Arg Asn Leu Lys Val Ile Thr Glu
                405                 410             


<210> 2706
<211> 200
<212> PRT
<213> Homo sapiens

<400> 2706
Met Phe Gln Leu His Glu Arg Phe Ser Lys Arg Arg Tyr Cys Leu Trp
 1               5                  10                  15      
Glu Lys Lys His Arg Glu Gly Arg Gly Glu Ile Pro Glu Asn Gly Lys
            20                  25                  30          
Lys Asp Gln Arg Val Ser Gly Lys Val Ile Asp Ser Thr Ile Tyr Ile
        35                  40                  45              
Leu Lys Gln Pro His Phe Ser Lys Val Asn Lys Asn Gly Arg Val Glu
    50                  55                  60                  
Tyr Cys Pro Cys Glu Ile Asn Arg Tyr Lys Cys Ser Asn Ser Gln Asp
65                  70                  75                  80  
Ser Ile Leu Met Ala Glu Ala Gly His Pro Gln Arg Glu Gly Ala Gly
                85                  90                  95      
Gly Gly Gly Arg Arg Asn Cys Asp Ser Ser Asn Gly Ser Ser Gly Ser
            100                 105                 110         
Pro Val Pro Cys Val Pro Glu Ala Val Thr Cys Ile Pro Glu Ala Val
        115                 120                 125             
Thr Cys Thr Asp Pro Asn Leu Val Trp Pro Gly Leu Pro Asp Ser Asn
    130                 135                 140                 
Tyr Leu Asp Ala Ser Ile Ser Leu Ile Ile Val Phe Leu Pro Gln Pro
145                 150                 155                 160 
Leu Leu Asp Lys Lys Val Pro Lys Leu Ala Thr Gly Glu Val Leu Gly
                165                 170                 175     
Val Glu Thr Ala Lys Cys Gly Ile Gln Ala Val Val Pro Pro Pro Ala
            180                 185                 190         
Leu Arg Glu Gly Val Leu Gly Tyr
        195                 200 


<210> 2707
<211> 611
<212> PRT
<213> Homo sapiens

<400> 2707
Met Asp Cys Glu Thr His His Leu Lys Gly Ile Asp Ser Ala Ala Ile
 1               5                  10                  15      
Asn Arg Thr Lys His Val Pro Ala Ala Leu Leu Met Ala Arg Gln Leu
            20                  25                  30          
Ala Ser Gln Thr Pro Pro Leu Gly Val Thr Met Thr His Gly Ser Asp
        35                  40                  45              
Arg Ser Lys Glu Ile Ser Ser Asp Arg Ala Val Asn Asp Glu Leu Arg
    50                  55                  60                  
Leu Ser Pro Leu Ala Gly Lys Gly Pro Tyr His Pro Thr Ala Glu Phe
65                  70                  75                  80  
Thr Leu Phe Thr Ala Thr Leu Ala Arg Thr Arg Lys Arg Ser Ile Cys
                85                  90                  95      
Gly Gly Arg Ser Gln Ser Ser Leu Pro Gln Leu Val Ala Ser Asp Thr
            100                 105                 110         
Gln Glu Gly Gly Gln Leu Ser Arg Ala Ser Pro Asp Leu Trp Arg Ser
        115                 120                 125             
His Thr His Leu Ser Thr Arg Asn Ala Trp Gly Thr Gly Ala Ala Ser
    130                 135                 140                 
Gly Thr Leu Glu Pro Ala Gly Gln Arg Ser Arg Thr Ser Ser Thr Asp
145                 150                 155                 160 
Cys Trp Leu Pro Ala Pro Ser Ile Ser Ser Val Arg Val Leu Thr Thr
                165                 170                 175     
Tyr Cys Val Pro Ser Ala Phe Ser Ala Ala Ser Ala Cys Arg Asp Val
            180                 185                 190         
Leu Gln Ser Pro Tyr Phe Ala Ser Ala Pro Trp Thr Ala Pro Gly Arg
        195                 200                 205             
Trp Arg Gln Gly Ser Ser Thr Asp Lys Gln Leu Pro Leu Tyr Cys Cys
    210                 215                 220                 
Cys Leu Val Lys Ala Arg Val Thr Glu Gly Gln His Leu Gly Ala Ser
225                 230                 235                 240 
Glu Pro Gly Pro Val Lys Gly Asp Thr Ser Leu Ala Gln Arg Ala Arg
                245                 250                 255     
Asn Leu Ser Pro Gly Asn Glu Ile Leu Tyr Gln Lys Gln Ser Arg Ser
            260                 265                 270         
Leu Glu Asn Lys Arg Leu Gln Ile Lys Lys Ala Ile Ser Pro Pro Glu
        275                 280                 285             
Gln Ser Gly Leu Thr Arg Ser Gly Ser Leu Pro Gln Ser Cys Lys Gly
    290                 295                 300                 
Leu Lys Trp Leu Cys Ser Leu Val Pro Val Glu Ala Gly Pro Glu Arg
305                 310                 315                 320 
Arg Arg Glu Lys Lys Ala Ser Glu Ser Thr Thr Arg Trp Arg Lys Ser
                325                 330                 335     
Ser Thr Val Glu Trp Thr Arg Cys Arg His Trp Thr Gln Ala Gly Leu
            340                 345                 350         
Thr Arg Phe Ser Leu Val Glu Leu Gly Asn Gly Pro Leu Arg Phe Leu
        355                 360                 365             
Ser Ser Met Phe Gly Ser Cys Ala Gln Ile Cys Ser Ser Glu Ile Arg
    370                 375                 380                 
Val Gly Ser Glu Ile Leu Leu Leu Arg Leu Gln Gln Arg Pro Gly Glu
385                 390                 395                 400 
His Leu Lys Gly Ser Ser Arg Val Val Glu Ile Gly Val Gln Pro Glu
                405                 410                 415     
Ala Cys Val Pro Ala Asn Leu Glu Arg Gln Val Phe Pro Glu Ile Ala
            420                 425                 430         
Ser Glu Pro Gln Asn Phe Met Phe Phe Ser Pro Glu Thr Leu Lys Thr
        435                 440                 445             
Ser Pro Met Ser Ser Gln Arg Ser Pro Gln Asp Phe Ser Gly Phe Gly
    450                 455                 460                 
Asn Met Leu Thr Gly Ile Leu Ala Arg Gly Phe Ser Phe Leu Asp Leu
465                 470                 475                 480 
Asp Phe Arg Leu Ile Leu Asp Asn Trp Gln Met Gly Thr Cys Tyr Ala
                485                 490                 495     
Ala Leu Met Gln Arg Ala Asn Asn Ile Asp Val Tyr Lys Ile Leu Lys
            500                 505                 510         
Glu Lys Leu Gln Asp Met Pro Ala Glu Lys Thr Arg Val Thr Thr Arg
        515                 520                 525             
Gly Arg Cys Tyr Ser Thr Ile Phe Leu Gln Lys Leu Arg Ser Ala Asn
    530                 535                 540                 
Met Asp Ile Arg Ile Ser Ile Val Phe Glu Ala Lys Ser Lys Asp Ala
545                 550                 555                 560 
Ser Gly Glu Lys Gly Gln His Ala Leu Ser Asp Arg His Ser Tyr Gly
                565                 570                 575     
Lys Thr Glu Pro Cys Gln Leu Pro Gly Lys Pro Val Asn Ser Pro Arg
            580                 585                 590         
Lys Pro Ser Gly Gln Leu Arg Gly Ile Arg Asp Glu Asn Pro Glu Leu
        595                 600                 605             
Phe Leu Glu
    610     


<210> 2708
<211> 923
<212> PRT
<213> Homo sapiens

<400> 2708
Met Pro Pro Asn Lys Arg Lys Val Leu Gly Arg Asn Gly Glu Lys Phe
 1               5                  10                  15      
Leu Gly Lys Thr Ser Met Ser Gly Ser Ser Pro Arg Arg Gly Leu Gln
            20                  25                  30          
Asp Arg Glu Val Lys Glu Ala Pro Ala Pro Gly Ala Arg Thr Thr Glu
        35                  40                  45              
Glu Gln Lys His Gln Pro Leu Thr Gln His Gln Leu Val Pro Gly Pro
    50                  55                  60                  
Arg Gln Arg Arg Gln Ser Ile Thr Val Glu Pro Gly Ser Arg Val Ala
65                  70                  75                  80  
Pro Glu His Ser Ile Leu Phe Leu His Pro Leu Val Gly Gly Leu Ala
                85                  90                  95      
Ile Glu Ala Gly Ser Ser Gln Lys Arg Thr Cys Gln Gly Gln Asp Lys
            100                 105                 110         
Ala Leu His Leu Glu Ser Gln Phe Thr Trp Ile Leu Thr Ala Lys Pro
        115                 120                 125             
Thr Ser Pro Ser Leu Pro Arg Asp Leu Ile Ile Val Ser Asn Asn His
    130                 135                 140                 
Pro Leu Met Leu Arg Ala Ala Ser Pro His Leu Ala Thr Gln Val Pro
145                 150                 155                 160 
Glu Gln Gly Ser Asp Ser Ala Ser Pro Gly Gln Gln Gly Lys Gly Thr
                165                 170                 175     
Glu Arg Arg Gln Gly Ala Ala Ser Gly Gly Cys Pro Glu Glu Pro Pro
            180                 185                 190         
Cys Lys Ser Leu Lys Val Gln Ser Gln Tyr Phe Gln Asn Val Leu Pro
        195                 200                 205             
Cys Leu Lys Glu Thr Gly Thr Cys Lys Met Gln Cys Val Phe Ala Lys
    210                 215                 220                 
Leu Lys Pro Ser Glu Pro Ser Ser Lys Val Leu Gly Asn Pro Ser Leu
225                 230                 235                 240 
Asp Ala Gln Thr Val Phe Gln Asp Val Arg Ala Ala Gly Ser Ser Leu
                245                 250                 255     
Ser Leu Phe Leu Thr Gly Asp Ala Ala Ala Ala Pro Gly Thr Glu Asn
            260                 265                 270         
Asn Ile Leu Gln Thr Arg Ala Ala Gln Thr Glu Leu His Thr Leu Cys
        275                 280                 285             
Gly Pro Pro Thr Asn Ala Ile Leu Gly Gln Thr Leu Asn Asn Glu Asn
    290                 295                 300                 
Pro Thr Lys Ile Gln Pro Gln Leu Gln Ala Gly Phe Glu Asp His Ile
305                 310                 315                 320 
Ser His Arg Leu Pro Gln Lys Trp Val Leu Thr Glu Glu Val Pro Phe
                325                 330                 335     
Gly Ala Glu Ile Gln Lys Arg Glu Ser Pro Phe Pro Gly Cys Gly Lys
            340                 345                 350         
Gly His Met Asn Ser His Gly Thr Lys Asn Ala Thr Val Gln Ala Ser
        355                 360                 365             
Ser Gly Phe Leu Gly Arg Leu Thr Gly Leu Ala Asp Ala Asn Gly Ser
    370                 375                 380                 
Gly Ala Lys Ser His Leu Gly Thr Gln Asp Ala Ala Pro Ser Gly Gly
385                 390                 395                 400 
Thr Glu Asp Thr Ala Leu Leu His Glu His Pro Gly Leu Arg Thr Pro
                405                 410                 415     
Ile Gln Thr Gln Asp Thr Pro Leu Leu Pro Arg Pro Pro Gly Arg Cys
            420                 425                 430         
Thr Pro Thr Gln Ala Pro Arg Pro Leu His Ser Tyr Met Asn Thr Gln
        435                 440                 445             
Asp Thr Glu Pro Thr Gln Ile Leu Lys Thr Leu His Pro Tyr Leu Gly
    450                 455                 460                 
Thr Gln Gly Arg Cys Ala Ser Pro Arg Ala Pro Arg Thr Leu Gly Leu
465                 470                 475                 480 
Leu Arg Gln Ala Pro Gln Pro Leu Ala Gly Pro Ser Val Pro Gln Gly
                485                 490                 495     
Thr Lys Gly Arg Lys Leu Lys Trp Asn Lys Gly Pro Gly Pro Phe Pro
            500                 505                 510         
Leu Leu Gly Ser Gly Leu Leu Ala His Gly Pro Lys Pro Ser Ser Ala
        515                 520                 525             
Ala Leu Arg Ser Ala Ala Leu Arg Arg Pro Gly Asn Pro Ser Pro Gly
    530                 535                 540                 
Ile Arg Ser Leu Leu Ser Ala Glu Arg Leu Arg Leu Leu Pro Gln Arg
545                 550                 555                 560 
Gln Thr Arg Arg Phe Thr Asp Phe His Pro Ile Thr Gly Cys Leu Cys
                565                 570                 575     
Gln Cys Arg Ala Gln Pro Phe Tyr Val Gly Leu Cys Ala Gly Leu His
            580                 585                 590         
Gly Ala Trp Asn Gln Ala His Val Glu Pro Ile Leu Ala Leu Pro Arg
        595                 600                 605             
Phe Ala Val Trp Leu Gly Ser Met Thr His Ala Ser Glu Ser Gln Cys
    610                 615                 620                 
Leu Phe Leu Ser His Gly Asp Ala Ala Ser Ile Pro Glu Ala Gly Arg
625                 630                 635                 640 
Thr Leu Asn Ala Pro Asp Cys Ser Ser Pro Lys Gly Ser His Met Gln
                645                 650                 655     
Ala Pro Ser Pro His Thr Leu Pro Val Thr Ala Ser Leu Leu Leu Asn
            660                 665                 670         
Glu His Pro Ser Ala Trp Pro Leu Arg Asp Ser Asp Ser Glu Lys Leu
        675                 680                 685             
Glu Ser Trp Val Arg Leu Cys Pro Val Pro Arg Arg Gln Leu Lys Thr
    690                 695                 700                 
Ile Pro Ser His Ala Gly Thr Leu His Ala Ala Ile Glu Ser Tyr Gly
705                 710                 715                 720 
Asp Leu Gln Thr Tyr Gln Arg Gly Ser Arg Gln Asp Glu Gly Asn Thr
                725                 730                 735     
Arg Asp Trp Lys Ser Ala Asn Leu Ser Ser Ile Pro Ala Leu His Phe
            740                 745                 750         
Gln Ala Met Trp Ala Pro Arg Gln Lys Met Arg Leu Val Met Pro Thr
        755                 760                 765             
Cys Glu Gly Pro Ser Tyr Leu Arg Thr His Leu Pro Cys Pro Asn Val
    770                 775                 780                 
Leu Gly Thr Asp Val Asn Ser Gly Ala Ala Gly Gln Arg Gly Glu Cys
785                 790                 795                 800 
Asp Thr Ser Pro Ser Ser Gly Gly His Ser Pro Val Met Cys Leu Gly
                805                 810                 815     
Ser Ser Ala Lys Lys His Glu Ala Ile Ile Leu His Met Thr Val Tyr
            820                 825                 830         
Asn Gly Gly Asn Met Val Arg Gln His Pro Gly Pro Lys Gln Arg Arg
        835                 840                 845             
Leu Gly Ser Gln Gln Ala Gly Glu Ser Thr Val Ile Thr Lys Asp Arg
    850                 855                 860                 
Gly Glu Ala Arg Pro Val Leu Gln Ser Phe Arg Arg Gly Arg Leu Gly
865                 870                 875                 880 
Arg Thr Trp Arg Tyr Pro Glu Thr Asn Lys His Leu Gln Pro Gly Val
                885                 890                 895     
Gly Asp Lys Tyr His Glu Ser Thr Val Lys Thr Thr Leu Asn Gly Leu
            900                 905                 910         
Leu Ser Ser Thr Glu Gly Lys Cys Ser Thr Ser
        915                 920             


<210> 2709
<211> 158
<212> PRT
<213> Homo sapiens

<400> 2709
Met Pro Phe Pro Gln Arg Leu Thr Glu Ser Glu Ile Val Thr Glu Thr
 1               5                  10                  15      
Glu Thr Asn Gly Cys Arg Asp Pro Glu Gly Arg Arg Thr Gly Lys Leu
            20                  25                  30          
Gly Ala Val Asp Arg Pro Ala Pro Arg Glu Arg Gly His Ser Gly Arg
        35                  40                  45              
Arg Ser Ala Arg Pro Leu Arg Ala Glu Arg Gly Gly Gly Pro Asp Ser
    50                  55                  60                  
Gly Gly Arg Arg Gly Arg Arg Arg Asn Leu Thr Ser Pro Arg Pro Lys
65                  70                  75                  80  
Ala Ala Gly Ala Lys Phe Ala Pro Gly Asp His Ser Asn Ala Ser Pro
                85                  90                  95      
Leu Gly Leu Glu Ala Val Arg Ala Arg Val Gly Ala Gly Gly Pro Arg
            100                 105                 110         
Trp Gly Gly Val Gly Pro Gly Val Ser Ala Ser Arg Ser His Cys Ala
        115                 120                 125             
Ser Ala Arg Trp Pro Gly Arg Arg Leu Gly Glu Arg Thr Gly Gly Asp
    130                 135                 140                 
Arg Arg His Phe Pro Gly Cys Gly Trp Arg Pro Ser Glu Pro
145                 150                 155             


<210> 2710
<211> 1006
<212> PRT
<213> Homo sapiens

<400> 2710
Met His Tyr Asp Gly His Val Arg Phe Asp Leu Pro Pro Gln Gly Ser
 1               5                  10                  15      
Val Leu Ala Arg Asn Val Ser Thr Arg Ser Cys Pro Pro Arg Thr Ser
            20                  25                  30          
Pro Ala Val Asp Leu Glu Glu Glu Glu Glu Glu Ser Ser Val Asp Gly
        35                  40                  45              
Lys Gly Asp Arg Lys Ser Thr Gly Leu Lys Leu Ser Lys Lys Lys Ala
    50                  55                  60                  
Arg Arg Arg His Thr Asp Asp Pro Ser Lys Glu Cys Phe Thr Leu Lys
65                  70                  75                  80  
Phe Asp Leu Asn Val Asp Ile Glu Thr Glu Ile Val Pro Ala Met Lys
                85                  90                  95      
Lys Lys Ser Leu Gly Glu Val Leu Leu Pro Val Phe Glu Arg Lys Gly
            100                 105                 110         
Ile Ala Leu Gly Lys Val Asp Ile Tyr Leu Asp Gln Ser Asn Thr Pro
        115                 120                 125             
Leu Ser Leu Thr Phe Glu Ala Tyr Arg Phe Gly Gly His Tyr Leu Arg
    130                 135                 140                 
Val Lys Ala Pro Ala Lys Pro Gly Asp Glu Gly Lys Val Glu Gln Gly
145                 150                 155                 160 
Met Lys Asp Ser Lys Ser Leu Ser Leu Pro Ile Leu Arg Pro Ala Gly
                165                 170                 175     
Thr Gly Pro Pro Ala Leu Glu Arg Val Asp Ala Gln Ser Arg Arg Glu
            180                 185                 190         
Ser Leu Asp Ile Leu Ala Pro Gly Arg Arg Arg Lys Asn Met Ser Glu
        195                 200                 205             
Phe Leu Gly Glu Ala Ser Ile Pro Gly Gln Glu Pro Pro Thr Pro Ser
    210                 215                 220                 
Ser Cys Ser Leu Pro Ser Gly Ser Ser Gly Ser Thr Asn Thr Gly Asp
225                 230                 235                 240 
Ser Trp Lys Asn Arg Ala Ala Ser Arg Phe Ser Gly Phe Phe Ser Ser
                245                 250                 255     
Gly Pro Ser Thr Ser Ala Phe Gly Arg Glu Val Asp Lys Met Glu Gln
            260                 265                 270         
Leu Glu Gly Lys Leu His Thr Tyr Ser Leu Phe Gly Leu Pro Arg Leu
        275                 280                 285             
Pro Arg Gly Leu Arg Phe Asp His Asp Ser Trp Glu Glu Glu Tyr Asp
    290                 295                 300                 
Glu Asp Glu Asp Glu Asp Asn Ala Cys Leu Arg Leu Glu Asp Ser Trp
305                 310                 315                 320 
Arg Glu Leu Ile Asp Gly His Glu Lys Leu Thr Arg Arg Gln Cys His
                325                 330                 335     
Gln Gln Glu Ala Val Trp Glu Leu Leu His Thr Glu Ala Ser Tyr Ile
            340                 345                 350         
Arg Lys Leu Arg Val Ile Ile Asn Leu Phe Leu Cys Cys Leu Leu Asn
        355                 360                 365             
Leu Gln Glu Ser Gly Leu Leu Cys Glu Val Glu Ala Glu Arg Leu Phe
    370                 375                 380                 
Ser Asn Ile Pro Glu Ile Ala Gln Leu His Arg Arg Leu Trp Ala Ser
385                 390                 395                 400 
Val Met Ala Pro Val Leu Glu Lys Ala Arg Arg Thr Arg Ala Leu Leu
                405                 410                 415     
Gln Pro Gly Asp Phe Leu Lys Gly Phe Lys Met Phe Gly Ser Leu Phe
            420                 425                 430         
Lys Pro Tyr Ile Arg Tyr Cys Met Glu Glu Glu Gly Cys Met Glu Tyr
        435                 440                 445             
Met Arg Gly Leu Leu Arg Asp Asn Asp Leu Phe Arg Ala Tyr Ile Thr
    450                 455                 460                 
Trp Ala Glu Lys His Pro Gln Cys Gln Arg Leu Lys Leu Ser Asp Met
465                 470                 475                 480 
Leu Ala Lys Pro His Gln Arg Leu Thr Lys Tyr Pro Leu Leu Leu Lys
                485                 490                 495     
Ser Val Leu Arg Lys Thr Glu Glu Pro Arg Ala Lys Glu Ala Val Val
            500                 505                 510         
Ala Met Ile Gly Ser Val Glu Arg Phe Ile His His Val Asn Ala Cys
        515                 520                 525             
Met Arg Gln Arg Gln Glu Arg Gln Arg Leu Ala Ala Val Val Ser Arg
    530                 535                 540                 
Ile Asp Ala Tyr Glu Val Val Glu Ser Ser Ser Asp Glu Val Asp Lys
545                 550                 555                 560 
Leu Leu Lys Glu Phe Leu His Leu Asp Leu Thr Ala Pro Ile Pro Gly
                565                 570                 575     
Ala Ser Pro Glu Glu Thr Arg Gln Leu Leu Leu Glu Gly Ser Leu Arg
            580                 585                 590         
Met Lys Glu Gly Lys Asp Ser Lys Met Asp Val Tyr Cys Phe Leu Phe
        595                 600                 605             
Thr Asp Leu Leu Leu Val Thr Lys Ala Val Lys Lys Ala Glu Arg Thr
    610                 615                 620                 
Arg Val Ile Arg Pro Pro Leu Leu Val Asp Lys Ile Val Cys Arg Glu
625                 630                 635                 640 
Leu Arg Asp Pro Gly Ser Phe Leu Leu Ile Tyr Leu Asn Glu Phe His
                645                 650                 655     
Ser Ala Val Gly Ala Tyr Thr Phe Gln Ala Ser Gly Gln Ala Leu Cys
            660                 665                 670         
Arg Gly Trp Val Asp Thr Ile Tyr Asn Ala Gln Asn Gln Leu Gln Gln
        675                 680                 685             
Leu Arg Ala Gln Glu Pro Pro Gly Ser Gln Gln Pro Leu Gln Ser Leu
    690                 695                 700                 
Glu Glu Glu Glu Asp Glu Gln Glu Glu Glu Glu Glu Glu Glu Glu Glu
705                 710                 715                 720 
Glu Glu Glu Gly Glu Asp Ser Gly Thr Ser Ala Ala Ser Ser Pro Thr
                725                 730                 735     
Ile Met Arg Lys Ser Ser Gly Ser Pro Asp Ser Gln His Cys Ala Ser
            740                 745                 750         
Asp Gly Ser Thr Glu Thr Leu Ala Met Val Val Val Glu Pro Gly Asp
        755                 760                 765             
Thr Leu Ser Ser Pro Glu Phe Asp Ser Gly Pro Phe Ser Ser Gln Ser
    770                 775                 780                 
Asp Glu Thr Ser Leu Ser Thr Thr Ala Ser Ser Ala Thr Pro Thr Ser
785                 790                 795                 800 
Glu Leu Leu Pro Leu Gly Pro Val Asp Gly Arg Ser Cys Ser Met Asp
                805                 810                 815     
Ser Ala Tyr Gly Thr Leu Ser Pro Thr Ser Leu Gln Asp Phe Val Ala
            820                 825                 830         
Pro Gly Pro Met Ala Glu Leu Val Pro Arg Ala Pro Glu Ser Pro Arg
        835                 840                 845             
Val Pro Ser Pro Pro Pro Ser Pro Arg Leu Arg Arg Arg Thr Pro Val
    850                 855                 860                 
Gln Leu Leu Ser Cys Pro Pro His Leu Leu Lys Ser Lys Ser Glu Ala
865                 870                 875                 880 
Ser Leu Leu Gln Leu Leu Ala Gly Ala Gly Thr His Gly Thr Pro Ser
                885                 890                 895     
Ala Pro Ser Arg Ser Leu Ser Glu Leu Cys Leu Ala Val Pro Ala Pro
            900                 905                 910         
Gly Ile Arg Thr Gln Gly Ser Pro Gln Glu Ala Gly Pro Ser Trp Asp
        915                 920                 925             
Cys Arg Gly Ala Pro Ser Pro Gly Ser Gly Pro Gly Leu Val Gly Cys
    930                 935                 940                 
Leu Ala Gly Glu Pro Ala Gly Ser His Arg Lys Arg Cys Gly Asp Leu
945                 950                 955                 960 
Pro Ser Gly Ala Ser Pro Arg Val Gln Pro Glu Pro Pro Pro Gly Val
                965                 970                 975     
Ser Ala Gln His Arg Lys Leu Thr Leu Ala Gln Leu Tyr Arg Ile Arg
            980                 985                 990         
Thr Thr Leu Leu Leu Asn Ser Thr Leu Thr Ala Ser Glu Val
        995                 1000                1005    


<210> 2711
<211> 365
<212> PRT
<213> Homo sapiens

<400> 2711
Met Gly Pro Glu Leu His Pro Thr Pro Gly Ser Met His His Cys Leu
 1               5                  10                  15      
Gly Lys Tyr Val Thr Ala Ile Ile Ser Leu Phe Leu Leu Ser Phe Phe
            20                  25                  30          
Leu Arg Glu Lys Ile Gln Asn Ala Glu Tyr Lys Leu Leu Leu Leu Glu
        35                  40                  45              
Tyr Ile Val Val Leu Val His Leu Ser Gly Pro Asp Pro Glu Trp Leu
    50                  55                  60                  
Gly Gln Thr Ala Ala Thr Ile Ser Gly Leu Phe Thr Pro Gln Ile Arg
65                  70                  75                  80  
Ala Gly Lys Leu Leu Val Ile Asn His Ser Ser Pro Leu Pro Gly Asp
                85                  90                  95      
Leu Ser Asp Val Asn His Ser Ser Leu Cys Glu Ala Leu Tyr Ser Arg
            100                 105                 110         
Gln Lys Val Asp His Ala Leu Leu Met Asn Phe Ala Ser Asn Leu Ser
        115                 120                 125             
Asp Tyr Phe Leu Leu Leu Glu Asp His Ile His Cys Thr Pro Lys Phe
    130                 135                 140                 
Ala Ala Ala Ile Ser Ser Ala Leu Ser Ala Trp Lys Glu Leu Pro Trp
145                 150                 155                 160 
Val Ile Leu Glu Phe Ser His Leu Ser Ile Ser Gly Lys Val Phe Cys
                165                 170                 175     
Thr Ser Asp Phe Ser Arg Leu Asn Thr Phe Phe Leu Leu Phe His Lys
            180                 185                 190         
Asp Thr Pro Thr His Leu Leu Leu Ser Glu Phe Arg Leu Leu Leu Ala
        195                 200                 205             
Gln Asn Ile Pro Ile His Phe Ser Pro Ser Val Phe His His Thr Gly
    210                 215                 220                 
Asn Tyr Ser Val Phe Asp Asp Met Cys Phe Ser Val Glu Lys Asp Arg
225                 230                 235                 240 
Val Phe Gly Glu Pro Asp Asn Pro Val Ala Thr Val Leu Thr Asp Met
                245                 250                 255     
Val Ser Met Leu Ala Val Ile Leu Gln Tyr Thr Tyr Thr Leu Asn Lys
            260                 265                 270         
Glu Gly Tyr Ser Thr Leu Asn Pro Leu Lys Gly Asn Tyr Leu Thr Val
        275                 280                 285             
Ile Leu Asp Arg Pro Gln Lys Asn Thr Gln Ile Ala Val Gly Arg Tyr
    290                 295                 300                 
Arg Leu Gln Gln Gly Gln Val Glu Pro Gly Tyr Asp Pro Gln Glu Asp
305                 310                 315                 320 
Pro Lys Ser Cys Ala Arg Tyr Ala Leu Leu Gly Pro Leu Val Gly Gly
                325                 330                 335     
Asn Leu Asp Gln Val Val Phe Ser Glu Glu Glu Ser Val Glu Gln Leu
            340                 345                 350         
Asn Cys Ile Arg Leu Leu Val Leu Ala Ser Gln Glu Ser
        355                 360                 365 


<210> 2712
<211> 824
<212> PRT
<213> Homo sapiens

<400> 2712
Met Asn Ile Leu Gln Arg Arg Thr Arg Ala Pro Glu Glu Leu Phe Val
 1               5                  10                  15      
Pro Gln Glu Ser Ser Gly Ser Thr Leu Glu Lys Thr Leu Val Ser Leu
            20                  25                  30          
His Gly Ser Ser Leu Arg Asn Glu Ala Thr Pro Arg Tyr Ser Gln Gln
        35                  40                  45              
Glu Glu Thr Gly Asn Gly Arg Trp Gln Gln Ser Leu Ser Leu Glu Arg
    50                  55                  60                  
Trp Pro Leu Trp Thr Ser His Pro Phe Gly Thr Pro Pro Leu Thr Pro
65                  70                  75                  80  
Val Ala Val Ala Gln Cys Cys Ile Leu Pro Val Leu Trp Pro Leu Leu
                85                  90                  95      
Ser Pro Pro Ser Gly Ser Ala Ser Pro Ile Ser Gln Gly Pro Gly Cys
            100                 105                 110         
Val Ser Leu Trp Pro Asn Ala Phe Asn Lys Asp Asp Phe Pro Val Arg
        115                 120                 125             
Gln Gly Asp Thr Ser Trp Ser Cys His Pro Val Ile Tyr Lys Arg Glu
    130                 135                 140                 
Arg Gly Glu Thr Ala Leu Lys Arg Asn Ala Thr Phe Trp Val Val Lys
145                 150                 155                 160 
Ala Ala Met Trp Leu Ile Pro His Ala Pro Cys Val Ile Ser Thr Pro
                165                 170                 175     
Ser Val Val Leu His Glu Phe His Pro Thr Ser Glu Lys Arg Leu Val
            180                 185                 190         
Gln Gln Ala Asn Ser Ile Gln Ile Leu Leu Phe Ser Ile Leu Thr Lys
        195                 200                 205             
Lys Ile Pro Lys Trp Tyr Ser Leu Asn Leu Glu Gln Lys Val Leu Ser
    210                 215                 220                 
Thr His Gln Glu Gln Trp Leu Pro Leu Gly Met Lys Trp Asp Asp Gly
225                 230                 235                 240 
Arg Pro Gly Glu Pro Trp Gln Glu Glu Thr Leu Met Met Arg Leu Leu
                245                 250                 255     
Ala Ile Gly His Ala Gln Asp Gln Ser Thr Val Gln Ile Leu Glu Gly
            260                 265                 270         
His His His Asp Pro Lys Val Gly Gly Lys Thr Ser Ser Pro Val Val
        275                 280                 285             
Ser Lys Asp Ile Thr Met Ile Leu Lys Arg Glu Glu Lys Pro Pro Pro
    290                 295                 300                 
Gln Ser Ser Ala Leu Asp Ile Ala Asn Ser Thr Pro Glu Ile Pro Glu
305                 310                 315                 320 
Leu Ile Arg Ile Thr Ser Asp Leu Gly Phe Thr His Thr Pro Ala Gly
                325                 330                 335     
Asn Pro Cys Met Ser Phe Val Arg Lys Gly Thr Lys Glu Thr Ser Leu
            340                 345                 350         
Lys Ser Ala Gly Ala Thr Gln Cys Lys Pro Thr Ala Glu Leu Thr Gln
        355                 360                 365             
Met Pro Glu Trp Ser Lys Thr Asn Ile Tyr Lys Ala Ile Ile Ala Ile
    370                 375                 380                 
Ser His Ile Phe Lys Arg Gly Val Pro Cys Ala Arg Glu Ala His Gly
385                 390                 395                 400 
Arg Val Asn Ala Thr Trp Asn Met Asn Ser Glu Asp Pro His Phe Gly
                405                 410                 415     
Phe His Glu Gly Gly Glu Gly Ser Pro Asn Lys Ser Ile Ser Asn Lys
            420                 425                 430         
Val Gln Ala Arg Arg Leu Leu Thr Gln Leu Gln Leu Gln Ser Pro Ala
        435                 440                 445             
Val Leu Thr Asn Asn Pro Ala Val Cys Asp His Lys Ser Thr Ala Ser
    450                 455                 460                 
Asn Trp Gly Glu Cys Glu Gly Arg Phe His Arg Glu Gly Glu Gly Ala
465                 470                 475                 480 
Ser Ser Ala Glu Glu Ala Ser Ala Pro Pro Lys Leu Arg Glu Asp Glu
                485                 490                 495     
Gly Ala Ser Ser Ala Glu Glu Ala Ser Ala Pro Pro Lys Leu Arg Glu
            500                 505                 510         
Asp Glu Gly Ala Ser Ser Ala Glu Val Ala Ser Ala Pro Pro Lys Leu
        515                 520                 525             
Arg Glu Gly Glu Gly Ala Ser Ser Ala Glu Glu Ala Ser Ala Leu Arg
    530                 535                 540                 
Lys Leu Arg Glu Gly Glu Gly Ala Ser Ser Ala Glu Glu Ala Ala Ala
545                 550                 555                 560 
Leu Gly Lys Arg Lys Leu Arg Glu Gly Glu Gly Ala Ser Ser Ala Glu
                565                 570                 575     
Glu Ala Ser Ala Leu Gln Lys Leu Arg Glu Gly Glu Gly Ala Ser Ser
            580                 585                 590         
Ala Glu Glu Leu Ser Ala Leu Arg Lys Leu Thr Glu Asp Glu Gly Ala
        595                 600                 605             
Ser Ser Ala Glu Glu Pro Ser Ala Pro Arg Arg Ser Pro Gln Pro Cys
    610                 615                 620                 
Gly Ser Ser Arg Arg Val Arg Ala Gln Ala His Gln Arg Lys Pro Gln
625                 630                 635                 640 
Pro Cys Gln Ser Gly Ser Ser Gly Lys Val Lys Ala Gln Ala Gln Gln
                645                 650                 655     
Arg Lys Pro Gln Ser Cys Gly Ser Gly Ser Gly Ser Ser Gly Arg Val
            660                 665                 670         
Arg Val Gln Ala Gln Gln Thr Glu Pro Gln Pro Cys Gly Ser Gly Ser
        675                 680                 685             
Ser Gly Arg Gly Glu Gly Ala Ser Ser Ala Glu Glu Ala Ser Ala Leu
    690                 695                 700                 
Pro Lys Arg Lys Leu Arg Glu Gly Glu Gly Ala Ser Ser Ala Glu Glu
705                 710                 715                 720 
Val Ser Ala Leu Ser Lys Leu Arg Glu Gly Glu Gly Ala Ser Ser Ala
                725                 730                 735     
Glu Lys Ala Ser Ala Leu Arg Lys Leu Gly Glu Gly Glu Gly Thr Ser
            740                 745                 750         
Ser Ala Glu Glu Ala Ser Ala Leu Arg Lys Arg Lys Leu Arg Glu Gly
        755                 760                 765             
Glu Gly Ala Ser Ser Ala Glu Glu Ala Ser Ala Leu Arg Lys Leu Arg
    770                 775                 780                 
Glu Gly Gln Lys Ser Pro Arg Met Gln Trp Glu Leu Asp Tyr Ala Val
785                 790                 795                 800 
Pro Phe Asp Asn Met Ile Ser Gln Ser Ala Ser Cys Ala Asp Ala Glu
                805                 810                 815     
Asn Phe Arg Gln Ile Arg Glu Gln
            820                 


<210> 2713
<211> 450
<212> PRT
<213> Homo sapiens

<400> 2713
Met Leu Leu Trp Thr Ala Val Leu Leu Phe Gly Lys Ser Thr Ser Met
 1               5                  10                  15      
Gly Ile Pro Ser Trp Ser Thr Lys Asp Leu Pro Cys Val Gly Lys Thr
            20                  25                  30          
Val Trp Leu Tyr Leu Gln Ala Trp Pro Asn Pro Val Phe Glu Gly Asp
        35                  40                  45              
Ala Leu Thr Leu Arg Cys Gln Gly Trp Lys Asn Thr Pro Leu Ser Gln
    50                  55                  60                  
Val Lys Phe Tyr Arg Asp Gly Lys Phe Leu His Phe Ser Lys Glu Asn
65                  70                  75                  80  
Gln Thr Leu Ser Met Gly Ala Ala Thr Val Gln Ser Arg Gly Gln Tyr
                85                  90                  95      
Ser Cys Ser Gly Gln Val Met Tyr Ile Pro Gln Thr Phe Thr Gln Thr
            100                 105                 110         
Ser Glu Thr Ala Met Val Gln Val Gln Glu Leu Phe Pro Pro Pro Val
        115                 120                 125             
Leu Ser Ala Ile Pro Ser Pro Glu Pro Arg Glu Gly Ser Leu Val Thr
    130                 135                 140                 
Leu Arg Cys Gln Thr Lys Leu His Pro Leu Arg Ser Ala Leu Arg Leu
145                 150                 155                 160 
Leu Phe Ser Phe His Lys Asp Gly His Thr Leu Gln Asp Arg Gly Pro
                165                 170                 175     
His Pro Glu Leu Cys Ile Pro Gly Ala Lys Glu Gly Asp Ser Gly Leu
            180                 185                 190         
Tyr Trp Cys Glu Val Ala Pro Glu Gly Gly Gln Val Gln Lys Gln Ser
        195                 200                 205             
Pro Gln Leu Glu Val Arg Val Gln Ala Pro Val Ser Arg Pro Val Leu
    210                 215                 220                 
Thr Leu His His Gly Pro Ala Asp Pro Ala Val Gly Asp Met Val Gln
225                 230                 235                 240 
Leu Leu Cys Glu Ala Gln Arg Gly Ser Pro Pro Ile Leu Tyr Ser Phe
                245                 250                 255     
Tyr Leu Asp Glu Lys Ile Val Gly Asn His Ser Ala Pro Cys Gly Gly
            260                 265                 270         
Thr Thr Ser Leu Leu Phe Pro Val Lys Ser Glu Gln Asp Ala Gly Asn
        275                 280                 285             
Tyr Ser Cys Glu Ala Glu Asn Ser Val Ser Arg Glu Arg Ser Glu Pro
    290                 295                 300                 
Lys Lys Leu Ser Leu Lys Gly Ser Gln Val Leu Phe Thr Pro Ala Ser
305                 310                 315                 320 
Asn Trp Leu Val Pro Trp Leu Pro Ala Ser Leu Leu Gly Leu Met Val
                325                 330                 335     
Ile Ala Ala Ala Leu Leu Val Tyr Val Arg Ser Trp Arg Lys Ala Gly
            340                 345                 350         
Pro Leu Pro Ser Gln Ile Pro Pro Thr Ala Pro Gly Gly Glu Gln Cys
        355                 360                 365             
Pro Leu Tyr Ala Asn Val His His Gln Lys Gly Lys Asp Glu Gly Val
    370                 375                 380                 
Val Tyr Ser Val Val His Arg Thr Ser Lys Arg Ser Glu Ala Arg Ser
385                 390                 395                 400 
Ala Glu Phe Thr Val Gly Arg Lys His Lys Ala Ser Pro Lys Phe His
                405                 410                 415     
Pro Thr Leu Asp Leu His Thr Lys Arg Leu Arg Val Asn Gly Arg Val
            420                 425                 430         
Gln Glu Ala Tyr Val Ala Leu Val Asn Thr Cys Ser Leu Thr Pro Ser
        435                 440                 445             
Leu Lys
    450 


<210> 2714
<211> 340
<212> PRT
<213> Homo sapiens

<400> 2714
Met Cys Leu Ser Val Cys Glu Asp Phe Pro Ser Lys Arg Lys Thr Glu
 1               5                  10                  15      
Pro Asp Met Asp Glu Val Pro Phe Trp Lys Ala Gln Glu Val Gly Trp
            20                  25                  30          
Glu Gly Glu Arg Val Arg Ile Val Ala Asn Thr Val Ile Glu Glu Cys
        35                  40                  45              
Leu Val Arg Leu Pro Ser Ile Tyr Asp His Tyr Val Leu Asp Ile Lys
    50                  55                  60                  
Glu His Ile Lys Gly Met Gly Ser Ser Ser Ser Ile Arg Gln Cys Thr
65                  70                  75                  80  
Phe Val Ala Ala Ala Val Lys Thr His Leu Asn Asp Asn Pro Leu Thr
                85                  90                  95      
Lys Asp Leu Leu Arg Ile Val Val Asp Leu Cys Leu Arg Asp Gln Asn
            100                 105                 110         
Ala Gly Gly Asp Val Val Leu Leu Leu Lys Ala Leu Ile Asp Asn Glu
        115                 120                 125             
Thr Arg Asn Lys Ala Leu Pro Gly Lys Val Pro Ser Arg Leu Leu Leu
    130                 135                 140                 
Leu Gln Gly Phe Val Glu Tyr Thr Gly Asp Asn Ile Asp Thr Ser Cys
145                 150                 155                 160 
Arg Val Ser Thr Thr Tyr Glu Asp Thr Pro Gly Ser Arg Asp Asn Thr
                165                 170                 175     
Phe Ser Ser Gly Arg Ser Leu Thr Leu Glu Gly Glu Lys Leu Lys Ala
            180                 185                 190         
Pro Ile Gln Ser Gln Gly Thr Gln Leu Lys Thr Leu Thr Lys Lys Pro
        195                 200                 205             
Ala Gln Glu Ile Leu Arg Cys Gly Trp Lys Met Gly Ser Leu Arg Leu
    210                 215                 220                 
Ala Ala Val Trp Ala Phe Ala Gly Pro Arg Arg Phe Cys Gly Val Leu
225                 230                 235                 240 
Gly Cys Ala Val Ala Gly Ser Gly Gly Arg Arg Cys Glu Gly Ser Cys
                245                 250                 255     
Arg Gly Ile Arg Arg Ala Ala Trp Arg Gly Ser Val Arg Asp Ala Cys
            260                 265                 270         
Gly Gln Ala Gly Thr Val Pro Lys Gly Lys Gly Met Pro Phe Gly Ala
        275                 280                 285             
Leu Trp Gly Ala Asp Gly Gly Glu Gly Cys Glu Gly Arg Gly Gly Ala
    290                 295                 300                 
Arg Val Ala Ala Gln Gly Pro Ala Cys Arg Arg Arg Cys Ala Arg Ala
305                 310                 315                 320 
Pro Asp Pro Arg Leu Glu Glu Glu Pro Pro Pro Pro Val Leu Ser Lys
                325                 330                 335     
Leu Ser Ile Gly
            340 


<210> 2715
<211> 474
<212> PRT
<213> Homo sapiens

<400> 2715
Met Ala Gln Pro Gly Lys Cys Ser Glu Lys Arg Ile Asn Lys Met Leu
 1               5                  10                  15      
Val Thr Asp Glu Asn Ile Ser Leu Ala Glu Leu Ala Lys Ala Ala Gly
            20                  25                  30          
Arg Arg Lys Pro Leu Ser Cys Val Leu Pro Ser Val His Arg Gly Leu
        35                  40                  45              
Gly Gly Pro Asn Glu Gly Met Thr Leu Lys Cys Glu Gln Gly Glu Gly
    50                  55                  60                  
Ala Glu Cys Ala Gln Gly Arg Glu Phe Thr Pro Leu Asp Ala Glu Leu
65                  70                  75                  80  
Pro Glu Lys Lys Arg Tyr Arg Val Pro Val Ala Glu Leu Gly Pro Ser
                85                  90                  95      
Ser Leu Gln Arg Arg Tyr Ile Lys Ala Pro His Glu Asp Phe Tyr Ser
            100                 105                 110         
Ser Thr Leu Asp Lys Leu Pro Leu Pro Glu Ile Glu Pro Thr Gly Lys
        115                 120                 125             
Glu Phe Glu Pro Arg Asn Ala Glu Thr Cys Ser Leu Ser Ala Ala Gly
    130                 135                 140                 
Leu Glu Ala Thr Gly Thr Pro Arg Lys Ile Pro Asp Gly Gly Ala Arg
145                 150                 155                 160 
Ala Gly Gly Pro Met Arg Lys Arg Glu Met Gly Glu Ala Glu Asn Trp
                165                 170                 175     
Leu Val Glu Ala Leu His Glu Gly Gly Asp Ser Gly Ala Val Gly Ser
            180                 185                 190         
Trp Arg Arg Gly Ala Lys Pro Arg Leu Ala Ala Pro Gly Gln Ser Arg
        195                 200                 205             
Ile Arg Arg Gly Gly Cys Ala Arg Arg Gly Ala Pro Gly Pro Gly Pro
    210                 215                 220                 
Arg Pro Ser Ala Arg Gly Arg Leu Glu Gly Val Arg Ala Ala Asp Asp
225                 230                 235                 240 
Gln Gly Ala Pro Ala Pro Gly Cys Ala Pro Gly Thr Arg Thr Val His
                245                 250                 255     
Pro Glu Val Ala Cys Ala Pro Lys Pro Gly Thr Ser Ala Ala Arg Gln
            260                 265                 270         
Gly Lys Gly Leu Cys Asp Pro Ser Pro Pro Gln Cys Val Cys Trp Gly
        275                 280                 285             
Val Gln His Pro Pro Cys Ala Thr Arg Val Leu Ala Pro Ala Leu Asp
    290                 295                 300                 
His Ser Pro Leu Ala Ser Ala Thr Arg Leu Ala Gln Ser Pro Ala Pro
305                 310                 315                 320 
Arg Pro Arg Leu Pro Leu Lys Gln Trp Leu Arg Gln Leu Gly Pro Thr
                325                 330                 335     
Trp Arg Pro Arg Leu Pro Ala Trp Gly Leu Arg Gln Lys Arg Ser Gly
            340                 345                 350         
Ala Ala Arg Ala Ala Gln Arg Thr Arg Ala Asp Ser Ser Leu Gln Asp
        355                 360                 365             
Arg Ala Met Glu Tyr Val Leu Val His Ser Trp Leu Cys Ser Ala Gly
    370                 375                 380                 
Gly Arg Glu Glu Ala Thr Phe Thr Pro Ser Ser Thr Cys Thr Ser Val
385                 390                 395                 400 
Glu Gly Thr Leu Ser Gly Gln Ala Ala Ala Leu Gly Asn Arg Arg Ser
                405                 410                 415     
Leu Gly Pro Ser Pro Cys Arg Arg Leu Cys Glu Pro Leu Gln Pro Ala
            420                 425                 430         
Phe Leu Leu Ala Ser Gly Glu Asp Tyr Asn Ile Pro Phe His Leu Asp
        435                 440                 445             
Ile Thr Ser Ser Leu Ala Lys His Leu Tyr Ser His Tyr Leu Ile Glu
    450                 455                 460                 
Pro Ser Gly Lys Ser Ile Asp Leu Gly Gln
465                 470                 


<210> 2716
<211> 108
<212> PRT
<213> Homo sapiens

<400> 2716
Met Arg Tyr Gln Arg Arg Val Arg Ala Pro Ala Pro Ala Ala Gly Ala
 1               5                  10                  15      
Ser Ala Pro Ala Trp Phe Cys Glu Lys Glu Ala Gly Leu Gly Pro Leu
            20                  25                  30          
Gly Ala Gly Pro Ser Pro Pro Leu Lys Ile Lys Val Trp Gly Glu Gly
        35                  40                  45              
Pro Asp Thr Arg Thr Tyr Leu Gln Glu Ala Phe Ser Glu Ser Arg Ala
    50                  55                  60                  
Glu Leu Ile Ser Thr Thr Ser Thr Tyr Arg Trp Leu Ala Arg Cys Gln
65                  70                  75                  80  
Ala Gly Arg His Arg Ala Ser Gly Gly Cys Gly Ala Pro Gly Arg Leu
                85                  90                  95      
Arg Thr Lys Arg Pro Leu Gly Thr Glu Ala Leu Ile
            100                 105             


<210> 2717
<211> 242
<212> PRT
<213> Homo sapiens

<400> 2717
Met Gly Ala Pro Arg Arg Asp Met Glu Leu Leu Ser Asn Ser Leu Ala
 1               5                  10                  15      
Ala Tyr Ala His Ile Arg Ser Gln Pro Arg Glu Leu Arg Pro Leu Leu
            20                  25                  30          
Arg Ala Gly Arg Leu Leu Arg Pro Ala Ala His Pro Leu Pro Ala Arg
        35                  40                  45              
His Gln His Leu Val Gly Ala Pro Pro Ala Ala Pro Gly Pro Gly Ser
    50                  55                  60                  
Ala Pro Gly Pro Pro Gln Gln His Pro Gly Ala Arg Gly Arg Arg Arg
65                  70                  75                  80  
Gly Arg Gly Gly His Gly Asp Ser Ala Gly Pro Arg Arg His Ala Ala
                85                  90                  95      
Gly Pro Arg Ala Val Arg Arg Ala Gly Arg Ala Pro Gln Arg Gln Arg
            100                 105                 110         
Leu His Val Gly Gly Gly Ala Gly Ala Gly Ala Ala Ala Gly Gly Ala
        115                 120                 125             
Arg Thr Asp Pro Ala Gly Asp Leu Ala His Arg Ala Ala Gly Pro Ala
    130                 135                 140                 
Gly His Arg His Ala Gly Ala Gln Pro His Gly His Gly His Pro Gly
145                 150                 155                 160 
Pro His Ala Leu Leu Leu Met Gly Pro Gly Ser Arg Cys Lys Ala Leu
                165                 170                 175     
Gly Val Pro Asp Leu His Met Ser Ser Glu Leu Pro His Thr Phe Gly
            180                 185                 190         
Leu Pro Arg Pro Pro Gln Leu Pro Gly Ala Thr Gly Arg Gly Pro Pro
        195                 200                 205             
Pro Pro Glu Arg Leu Pro Ser Pro Val Leu Pro Glu Asp Pro Gly Gly
    210                 215                 220                 
Gly Glu Gly Ala Ala Cys Arg Val Pro Thr Pro Ser Leu Gly Ser Met
225                 230                 235                 240 
Lys Arg
        


<210> 2718
<211> 107
<212> PRT
<213> Homo sapiens

<400> 2718
Met Val Ala Asn Val Lys Ser Leu Val Val Val Ala Ser Ile Phe Ile
 1               5                  10                  15      
Val Asn Glu Pro His Val Thr Tyr Asp Ala Val Ile Asp Asp Ile Leu
            20                  25                  30          
Ala Glu Gln Val Ile Val Thr Lys His His Arg Gly Leu Gln Leu Gly
        35                  40                  45              
Gln Met Leu Leu Gln Pro Gly Gln Leu Pro Phe Gln His Leu Tyr Leu
    50                  55                  60                  
Arg Asp Ile Cys Arg Lys Ala Gly Val Asp Leu Val Leu His Lys Arg
65                  70                  75                  80  
Glu Ile Ile Val His Leu Val Pro Glu Asp Gly Leu Gly Gln Ala Ala
                85                  90                  95      
Val Gly Val Asp Ser Met Asn Leu Cys His Phe
            100                 105         


<210> 2719
<211> 298
<212> PRT
<213> Homo sapiens

<400> 2719
Met Glu Asn Glu Glu Arg Gly Gly Glu Gly Glu Ile Gln Lys Ile Gly
 1               5                  10                  15      
Gly Lys Pro Trp Glu Gln Ile Lys Ala Gly Asn Gln Arg Asn Gln Ser
            20                  25                  30          
Gln Arg Ala Ser Gln Glu Glu Leu Met Ala Thr Ser Thr Glu Tyr His
        35                  40                  45              
Arg Ile Trp Asn Pro Arg Lys Pro Phe Ser Tyr Thr Lys Ala Phe Gln
    50                  55                  60                  
Phe Ile Ala Thr Ala Leu Lys Asn Ser Leu His Asn Tyr Thr Trp Asn
65                  70                  75                  80  
Leu Leu Gly Gln Glu Gly Lys Ala Leu Gln Cys Asn Gly Asp Ser Ser
                85                  90                  95      
Glu Met Phe Pro Leu Thr Leu Glu Met Ala Glu Ile Lys Phe Ala Ile
            100                 105                 110         
Cys Gly Arg Leu Phe Ala Ile Ile Ile Asp Ser Glu Ala Leu Ile Gly
        115                 120                 125             
Lys Gln Asn Lys Pro Lys Thr Pro Gly Leu Met Lys Thr Asn Met Glu
    130                 135                 140                 
Ala Ser Asp His Val Leu Gln Leu Leu Ala Met Ser Glu Ser Leu Ala
145                 150                 155                 160 
Ile Leu Lys Glu Ser His Ser Val Cys Leu Ile Lys Ala Thr Ile Phe
                165                 170                 175     
Leu Thr Cys Ser Gly Ala Gly Pro Leu Lys Glu Asn Ala Gly Arg His
            180                 185                 190         
Leu Ala Thr Gly Leu Ser Gln Thr Leu Lys His Arg Ala Val Leu Val
        195                 200                 205             
Leu Ala Val Gly Asp Gly Leu Leu Pro Pro Arg Phe Met Asn Cys His
    210                 215                 220                 
Ile Ser Leu Phe Asp Pro Pro Arg Val Ser Ser Val Pro Arg Ser Leu
225                 230                 235                 240 
Leu His Val Ile Ala Leu Phe Gln Ile Ile Ala Arg Glu Asn Ala Lys
                245                 250                 255     
Val Gly Asn Asp Gln Asp Ile Asp Glu Thr Pro Leu Thr Gln Ser Trp
            260                 265                 270         
Gly Thr Cys Glu Ala Arg Glu Gly Ser Met Leu Gly Val Val Leu Gly
        275                 280                 285             
Asp Glu Lys Val Thr Asp Pro Asp Leu Glu
    290                 295             


<210> 2720
<211> 287
<212> PRT
<213> Homo sapiens

<400> 2720
Met Leu Ser Ala Arg Arg Gly Arg Val Gly Ala Gly Gly Gly Gln Thr
 1               5                  10                  15      
Leu Leu Trp Ser Trp Leu Ser Val Ala Leu Ser Gly Ala Glu Asp Trp
            20                  25                  30          
Leu Gly Arg Gln Val Ser Arg Pro Ser Glu Asp Ser Asp Arg Gly Leu
        35                  40                  45              
Tyr Lys Lys Gln Ala Met Ala Lys Lys Arg Thr Pro Ser Thr Trp Gly
    50                  55                  60                  
Glu Arg Ser Pro Leu Asp Leu Val Gly Ser Ser Ala Arg Ala Phe Gly
65                  70                  75                  80  
Tyr Trp Trp Ala Cys Pro Ser Pro Val Pro Ala Pro Ala Cys Ser Thr
                85                  90                  95      
Leu Thr Arg Ser Thr Glu Thr His Pro Ala Leu Arg Gly Asn Leu Thr
            100                 105                 110         
Gln Ser Gln Ser Pro Val Thr Thr Thr Ala Gly Val Gln Ala Pro Val
        115                 120                 125             
Pro Pro Ser Trp Ala Val Leu Asn Leu Gln Gly Leu Gly Phe Phe Val
    130                 135                 140                 
Asn Asn Glu Gly Leu His Arg Leu Cys Arg Ala Arg Gly Arg Cys Gly
145                 150                 155                 160 
Arg Asn Pro Thr Trp Ala Pro Lys Ala Asp Lys Val Glu Cys Glu Gly
                165                 170                 175     
Val Tyr Lys Glu Thr Pro Cys Ala Pro Pro Leu Gln Leu Thr Trp Thr
            180                 185                 190         
His Ala Leu Leu Arg Pro Thr Leu Thr Leu Trp Ile Arg Leu Pro Leu
        195                 200                 205             
Ala Val Leu Ser Pro Gly Asp Gly Cys Val Trp Arg Ala Leu Ser Leu
    210                 215                 220                 
Leu Leu Pro Ala Lys Gly Cys Ile Gln His Ser Lys Glu Arg Val Trp
225                 230                 235                 240 
Gly Arg Leu Pro Gly Lys Val Gln Gln Pro Pro His Pro Gln Thr Leu
                245                 250                 255     
Arg Pro Leu Trp Thr Pro Pro Ala Gly Ala Ser Pro Pro Cys Glu Gly
            260                 265                 270         
Leu Val Ala Val Val Leu Leu Glu Gly Arg Thr Glu Gly Thr Leu
        275                 280                 285         


<210> 2721
<211> 105
<212> PRT
<213> Homo sapiens

<400> 2721
Met Pro Phe Leu Asp Ile Gln Lys Arg Phe Gly Leu Asn Ile Asp Arg
 1               5                  10                  15      
Trp Leu Thr Ile Gln Ser Gly Glu Gln Pro Tyr Lys Met Ala Gly Arg
            20                  25                  30          
Cys His Ala Phe Glu Lys Glu Trp Ile Glu Cys Ala His Gly Ile Gly
        35                  40                  45              
Tyr Thr Arg Ala Glu Lys Glu Cys Lys Ile Glu Tyr Asp Asp Phe Val
    50                  55                  60                  
Glu Cys Leu Leu Arg Gln Lys Thr Cys Ile Arg Asn Ser Glu Cys Val
65                  70                  75                  80  
Ser Leu Val Leu Thr Leu Glu Leu Leu Ser Pro Ala Ser Glu Cys Leu
                85                  90                  95      
Glu Arg Asn Tyr Ser Val Asn Asp Asp
            100                 105 


<210> 2722
<211> 2419
<212> PRT
<213> Homo sapiens

<400> 2722
Met Glu Gln Phe Pro Lys Glu Thr Val Val Glu Ser Ser Gly Pro Lys
 1               5                  10                  15      
Val Leu Glu Thr Ala Glu Glu Ile Gln Glu Arg Arg Gln Glu Val Leu
            20                  25                  30          
Thr Arg Tyr Gln Ser Phe Lys Glu Arg Val Ala Glu Arg Gly Gln Lys
        35                  40                  45              
Leu Glu Asp Ser Tyr His Leu Gln Val Phe Lys Arg Asp Ala Asp Asp
    50                  55                  60                  
Leu Gly Lys Trp Ile Met Glu Lys Val Asn Ile Leu Thr Asp Lys Ser
65                  70                  75                  80  
Tyr Glu Asp Pro Thr Asn Ile Gln Gly Lys Tyr Gln Lys His Gln Ser
                85                  90                  95      
Leu Glu Ala Glu Val Gln Thr Lys Ser Arg Leu Met Ser Glu Leu Glu
            100                 105                 110         
Lys Thr Arg Glu Glu Arg Phe Thr Met Gly His Ser Ala His Glu Glu
        115                 120                 125             
Thr Lys Ala His Ile Glu Glu Leu Arg His Leu Trp Asp Leu Leu Leu
    130                 135                 140                 
Glu Leu Thr Leu Glu Lys Gly Asp Gln Leu Leu Arg Ala Leu Lys Phe
145                 150                 155                 160 
Gln Gln Tyr Val Gln Glu Cys Ala Asp Ile Leu Glu Trp Ile Gly Asp
                165                 170                 175     
Lys Glu Ala Ile Ala Thr Ser Val Glu Leu Gly Glu Asp Trp Glu Arg
            180                 185                 190         
Thr Glu Val Leu His Lys Lys Phe Glu Asp Phe Gln Val Glu Leu Val
        195                 200                 205             
Ala Lys Glu Gly Arg Val Val Glu Val Asn Gln Tyr Ala Asn Glu Cys
    210                 215                 220                 
Ala Glu Glu Asn His Pro Asp Leu Pro Leu Ile Gln Ser Lys Gln Asn
225                 230                 235                 240 
Glu Val Asn Ala Ala Trp Glu Arg Leu Arg Gly Leu Ala Leu Gln Arg
                245                 250                 255     
Gln Lys Ala Leu Ser Asn Ala Ala Asn Leu Gln Arg Phe Lys Arg Asp
            260                 265                 270         
Val Thr Glu Ala Ile Gln Trp Ile Lys Glu Lys Glu Pro Val Leu Thr
        275                 280                 285             
Ser Glu Asp Tyr Gly Lys Asp Leu Val Ala Ser Glu Gly Leu Phe His
    290                 295                 300                 
Ser His Lys Gly Leu Glu Arg Asn Leu Ala Val Met Ser Asp Lys Val
305                 310                 315                 320 
Lys Glu Leu Cys Ala Lys Ala Glu Lys Leu Thr Leu Ser His Pro Ser
                325                 330                 335     
Asp Ala Pro Gln Ile Gln Glu Met Lys Glu Asp Leu Val Ser Ser Trp
            340                 345                 350         
Glu His Ile Arg Ala Leu Ala Thr Ser Arg Tyr Glu Lys Leu Gln Ala
        355                 360                 365             
Thr Tyr Trp Tyr His Arg Phe Ser Ser Asp Phe Asp Glu Leu Ser Gly
    370                 375                 380                 
Trp Met Asn Glu Lys Thr Ala Ala Ile Asn Ala Asp Glu Leu Pro Thr
385                 390                 395                 400 
Asp Val Ala Gly Gly Glu Val Leu Leu Asp Arg His Gln Gln His Lys
                405                 410                 415     
His Glu Ile Asp Ser Tyr Asp Asp Arg Phe Gln Ser Ala Asp Glu Thr
            420                 425                 430         
Gly Gln Asp Leu Val Asn Ala Asn His Glu Ala Ser Asp Glu Val Arg
        435                 440                 445             
Glu Lys Met Glu Ile Leu Asp Asn Asn Trp Thr Ala Leu Leu Glu Leu
    450                 455                 460                 
Trp Asp Glu Arg His Arg Gln Tyr Glu Gln Cys Leu Asp Phe His Leu
465                 470                 475                 480 
Phe Tyr Arg Asp Ser Glu Gln Val Asp Ser Trp Met Ser Arg Gln Glu
                485                 490                 495     
Ala Phe Leu Glu Asn Glu Asp Leu Gly Asn Ser Leu Gly Ser Ala Glu
            500                 505                 510         
Ala Leu Leu Gln Lys His Glu Asp Phe Glu Glu Ala Phe Thr Ala Gln
        515                 520                 525             
Glu Glu Lys Ile Ile Thr Val Asp Lys Thr Ala Thr Lys Leu Ile Gly
    530                 535                 540                 
Asp Asp His Tyr Asp Ser Glu Asn Ile Lys Ala Ile Arg Asp Gly Leu
545                 550                 555                 560 
Leu Ala Arg Arg Asp Ala Leu Arg Glu Lys Ala Ala Thr Arg Arg Arg
                565                 570                 575     
Leu Leu Lys Glu Ser Leu Leu Leu Gln Lys Leu Tyr Glu Asp Ser Asp
            580                 585                 590         
Asp Leu Lys Asn Trp Ile Asn Lys Lys Lys Lys Leu Ala Asp Asp Glu
        595                 600                 605             
Asp Tyr Lys Asp Ile Gln Asn Leu Lys Ser Arg Val Gln Lys Gln Gln
    610                 615                 620                 
Val Phe Glu Lys Glu Leu Ala Val Asn Lys Thr Gln Leu Glu Asn Ile
625                 630                 635                 640 
Gln Lys Thr Gly Gln Glu Met Ile Glu Gly Gly His Tyr Ala Ser Asp
                645                 650                 655     
Asn Val Thr Thr Arg Leu Ser Glu Val Ala Ser Leu Trp Glu Glu Leu
            660                 665                 670         
Leu Glu Ala Thr Lys Gln Lys Gly Thr Gln Leu His Glu Ala Asn Gln
        675                 680                 685             
Gln Leu Gln Phe Glu Asn Asn Ala Glu Asp Leu Gln Arg Trp Leu Glu
    690                 695                 700                 
Asp Val Glu Trp Gln Val Thr Ser Glu Asp Tyr Gly Lys Gly Leu Ala
705                 710                 715                 720 
Glu Val Gln Asn Arg Leu Arg Lys His Gly Leu Leu Glu Ser Ala Val
                725                 730                 735     
Ala Ala Arg Gln Asp Gln Val Asp Ile Leu Thr Asp Leu Ala Ala Tyr
            740                 745                 750         
Phe Glu Glu Ile Gly His Pro Asp Ser Lys Asp Ile Arg Ala Arg Gln
        755                 760                 765             
Glu Ser Leu Val Cys Arg Phe Glu Ala Leu Lys Glu Pro Leu Ala Thr
    770                 775                 780                 
Arg Lys Lys Lys Leu Leu Asp Leu Leu His Leu Gln Leu Ile Cys Arg
785                 790                 795                 800 
Asp Thr Glu Asp Glu Glu Ala Trp Ile Gln Glu Thr Glu Pro Ser Ala
                805                 810                 815     
Thr Ser Thr Tyr Leu Gly Lys Asp Leu Ile Ala Ser Lys Lys Leu Leu
            820                 825                 830         
Asn Arg His Arg Val Ile Leu Glu Asn Ile Ala Ser His Glu Pro Arg
        835                 840                 845             
Ile Gln Glu Ile Thr Glu Arg Gly Asn Lys Met Val Glu Glu Gly His
    850                 855                 860                 
Phe Ala Ala Glu Asp Val Ala Ser Arg Val Lys Ser Leu Asn Gln Asn
865                 870                 875                 880 
Met Glu Ser Leu Arg Ala Arg Ala Ala Arg Arg Gln Asn Asp Leu Glu
                885                 890                 895     
Ala Asn Val Gln Phe Gln Gln Tyr Leu Ala Asp Leu His Glu Ala Glu
            900                 905                 910         
Thr Trp Ile Arg Glu Lys Glu Pro Ile Val Asp Asn Thr Asn Tyr Gly
        915                 920                 925             
Ala Asp Glu Glu Ala Ala Gly Ala Leu Leu Lys Lys His Glu Ala Phe
    930                 935                 940                 
Leu Leu Asp Leu Asn Ser Phe Gly Asp Ser Met Lys Ala Leu Arg Asn
945                 950                 955                 960 
Gln Ala Asn Ala Cys Gln Gln Gln Gln Ala Ala Pro Val Glu Gly Val
                965                 970                 975     
Ala Gly Glu Gln Arg Val Met Ala Leu Tyr Asp Phe Gln Ala Arg Ser
            980                 985                 990         
Pro Arg Glu Val Thr Met Lys Lys Gly Asp Val Leu Thr Leu Leu Ser
        995                 1000                1005            
Ser Ile Asn Lys Asp Trp Trp Lys Val Glu Ala Ala Asp His Gln Gly
    1010                1015                1020                
Ile Val Pro Ala Val Tyr Val Arg Arg Leu Ala His Asp Glu Phe Pro
1025                1030                1035                1040
Met Leu Pro Gln Arg Arg Arg Glu Glu Pro Gly Asn Ile Thr Gln Arg
                1045                1050                1055    
Gln Glu Gln Ile Glu Asn Gln Tyr Arg Ser Leu Leu Asp Arg Ala Glu
            1060                1065                1070        
Glu Arg Arg Arg Arg Leu Leu Gln Arg Tyr Asn Glu Phe Leu Leu Ala
        1075                1080                1085            
Tyr Glu Ala Gly Asp Met Leu Glu Trp Ile Gln Glu Lys Lys Ala Glu
    1090                1095                1100                
Asn Thr Gly Val Glu Leu Asp Asp Val Trp Glu Leu Gln Lys Lys Phe
1105                1110                1115                1120
Asp Glu Phe Gln Lys Asp Leu Asn Thr Asn Glu Pro Arg Leu Arg Asp
                1125                1130                1135    
Ile Asn Lys Val Ala Asp Asp Leu Leu Phe Glu Gly Leu Leu Thr Pro
            1140                1145                1150        
Glu Gly Ala Gln Ile Arg Gln Glu Leu Asn Ser Arg Trp Gly Ser Leu
        1155                1160                1165            
Gln Arg Leu Ala Asp Glu Gln Arg Gln Leu Leu Gly Ser Ala His Ala
    1170                1175                1180                
Val Glu Val Phe His Arg Glu Ala Asp Asp Thr Lys Glu Gln Ile Glu
1185                1190                1195                1200
Lys Lys Cys Gln Ala Leu Ser Ala Ala Asp Pro Gly Ser Asp Leu Phe
                1205                1210                1215    
Ser Val Gln Ala Leu Gln Arg Arg His Glu Gly Phe Glu Arg Asp Leu
            1220                1225                1230        
Val Pro Leu Gly Asp Lys Val Thr Ile Leu Gly Glu Thr Ala Glu Arg
        1235                1240                1245            
Leu Ser Glu Ser His Pro Asp Ala Thr Glu Asp Leu Gln Arg Gln Lys
    1250                1255                1260                
Met Glu Leu Asn Glu Ala Trp Glu Asp Leu Gln Gly Arg Thr Lys Asp
1265                1270                1275                1280
Arg Lys Glu Ser Leu Asn Glu Ala Gln Lys Phe Tyr Leu Phe Leu Ser
                1285                1290                1295    
Lys Ala Arg Asp Leu Gln Asn Trp Ile Ser Ser Ile Gly Gly Met Val
            1300                1305                1310        
Ser Ser Gln Glu Leu Ala Glu Asp Leu Thr Gly Ile Glu Ile Leu Leu
        1315                1320                1325            
Glu Arg His Gln Glu His Arg Ala Asp Met Glu Ala Glu Ala Pro Thr
    1330                1335                1340                
Phe Gln Ala Leu Glu Asp Phe Ser Ala Glu Leu Ile Asp Ser Gly His
1345                1350                1355                1360
His Ala Ser Pro Glu Ile Glu Lys Lys Leu Gln Ala Val Lys Leu Glu
                1365                1370                1375    
Arg Asp Asp Leu Glu Lys Ala Trp Glu Lys Arg Lys Lys Ile Leu Asp
            1380                1385                1390        
Gln Cys Leu Glu Leu Gln Met Phe Gln Gly Asn Cys Asp Gln Val Glu
        1395                1400                1405            
Ser Trp Met Val Ala Arg Glu Asn Ser Leu Arg Ser Asp Asp Lys Ser
    1410                1415                1420                
Ser Leu Asp Ser Leu Glu Ala Leu Met Lys Lys Arg Asp Asp Leu Asp
1425                1430                1435                1440
Lys Ala Ile Thr Ala Gln Glu Gly Lys Ile Thr Asp Leu Glu His Phe
                1445                1450                1455    
Ala Glu Ser Leu Ile Ala Asp Glu His Tyr Ala Lys Glu Glu Ile Ala
            1460                1465                1470        
Thr Arg Leu Gln Arg Val Leu Asp Arg Trp Lys Ala Leu Lys Ala Gln
        1475                1480                1485            
Leu Ile Asp Glu Arg Thr Lys Leu Gly Asp Tyr Ala Asn Leu Lys Gln
    1490                1495                1500                
Phe Tyr Arg Asp Leu Glu Glu Leu Glu Glu Trp Ile Ser Glu Met Leu
1505                1510                1515                1520
Pro Thr Ala Cys Asp Glu Ser Tyr Lys Asp Ala Thr Asn Ile Gln Arg
                1525                1530                1535    
Lys Tyr Leu Lys His Gln Thr Phe Ala His Glu Val Asp Gly Arg Ser
            1540                1545                1550        
Glu Gln Val His Gly Val Ile Asn Leu Gly Asn Ser Leu Ile Glu Cys
        1555                1560                1565            
Ser Ala Cys Asp Gly Asn Glu Glu Ala Met Lys Glu Gln Leu Glu Gln
    1570                1575                1580                
Leu Lys Glu His Trp Asp His Leu Leu Glu Arg Thr Asn Asp Lys Gly
1585                1590                1595                1600
Lys Lys Leu Asn Glu Ala Ser Arg Gln Gln Arg Phe Asn Thr Ser Ile
                1605                1610                1615    
Arg Asp Phe Glu Phe Trp Leu Ser Glu Ala Glu Thr Leu Leu Ala Met
            1620                1625                1630        
Lys Asp Gln Ala Arg Asp Leu Ala Ser Ala Gly Asn Leu Leu Lys Lys
        1635                1640                1645            
His Gln Leu Leu Glu Arg Glu Met Leu Ala Arg Glu Asp Ala Leu Lys
    1650                1655                1660                
Asp Leu Asn Thr Leu Ala Glu Asp Leu Leu Ser Ser Gly Thr Phe Asn
1665                1670                1675                1680
Val Asp Gln Ile Val Lys Lys Lys Asp Asn Val Asn Lys Arg Phe Leu
                1685                1690                1695    
Asn Val Gln Glu Leu Ala Ala Ala His His Glu Lys Leu Lys Glu Ala
            1700                1705                1710        
Tyr Ala Leu Phe Gln Phe Phe Gln Asp Leu Asp Asp Glu Glu Ser Trp
        1715                1720                1725            
Ile Glu Glu Lys Leu Ile Arg Val Ser Ser Gln Asp Tyr Gly Arg Asp
    1730                1735                1740                
Leu Gln Gly Val Gln Asn Leu Leu Lys Lys His Lys Arg Leu Glu Gly
1745                1750                1755                1760
Glu Leu Val Ala His Glu Pro Ala Ile Gln Asn Val Leu Asp Met Ala
                1765                1770                1775    
Glu Lys Leu Lys Asp Lys Ala Ala Val Gly Gln Glu Glu Ile Gln Leu
            1780                1785                1790        
Arg Leu Ala Gln Phe Val Glu His Trp Glu Lys Leu Lys Glu Leu Ala
        1795                1800                1805            
Lys Ala Arg Gly Leu Lys Leu Glu Glu Ser Leu Glu Tyr Leu Gln Phe
    1810                1815                1820                
Met Gln Asn Ala Glu Glu Glu Glu Ala Trp Ile Asn Glu Lys Asn Ala
1825                1830                1835                1840
Leu Ala Val Arg Gly Asp Cys Gly Asp Thr Leu Ala Ala Thr Gln Ser
                1845                1850                1855    
Leu Leu Met Lys His Glu Ala Leu Glu Asn Asp Phe Ala Val His Glu
            1860                1865                1870        
Thr Arg Val Gln Asn Val Cys Ala Gln Gly Glu Asp Ile Leu Asn Lys
        1875                1880                1885            
Val Leu Gln Glu Glu Ser Gln Asn Lys Glu Ile Ser Ser Lys Ile Glu
    1890                1895                1900                
Ala Leu Asn Glu Lys Thr Pro Ser Leu Ala Lys Ala Ile Ala Ala Trp
1905                1910                1915                1920
Lys Leu Gln Leu Glu Asp Asp Tyr Ala Phe Gln Glu Phe Asn Trp Lys
                1925                1930                1935    
Ala Asp Val Val Glu Ala Trp Ile Ala Asp Lys Glu Thr Ser Leu Lys
            1940                1945                1950        
Thr Asn Gly Asn Gly Ala Asp Leu Gly Asp Phe Leu Thr Leu Leu Ala
        1955                1960                1965            
Lys Gln Asp Thr Leu Asp Ala Ser Leu Gln Ser Phe Gln Gln Glu Arg
    1970                1975                1980                
Leu Pro Glu Ile Thr Asp Leu Lys Asp Lys Leu Ile Ser Ala Gln His
1985                1990                1995                2000
Asn Gln Ser Lys Ala Ile Glu Glu Arg Tyr Ala Ala Leu Leu Lys Arg
                2005                2010                2015    
Trp Glu Gln Leu Leu Glu Ala Ser Ala Val His Arg Gln Lys Leu Leu
            2020                2025                2030        
Glu Lys Gln Leu Pro Leu Gln Lys Ala Glu Asp Leu Phe Val Glu Phe
        2035                2040                2045            
Ala His Lys Ala Ser Ala Leu Asn Asn Trp Cys Glu Lys Met Glu Glu
    2050                2055                2060                
Asn Leu Ser Glu Pro Val His Cys Val Ser Leu Asn Glu Ile Arg Gln
2065                2070                2075                2080
Leu Gln Lys Asp His Glu Asp Phe Leu Ala Ser Leu Ala Arg Ala Gln
                2085                2090                2095    
Ala Asp Phe Lys Cys Leu Leu Glu Leu Asp Gln Gln Ile Lys Ala Leu
            2100                2105                2110        
Gly Val Pro Ser Ser Pro Tyr Thr Trp Leu Thr Val Glu Val Leu Glu
        2115                2120                2125            
Arg Thr Trp Lys His Leu Ser Asp Ile Ile Glu Glu Arg Glu Gln Glu
    2130                2135                2140                
Leu Gln Lys Glu Glu Ala Arg Gln Val Lys Asn Phe Glu Met Cys Gln
2145                2150                2155                2160
Glu Phe Glu Gln Asn Ala Ser Thr Phe Leu Gln Trp Ile Leu Glu Thr
                2165                2170                2175    
Arg Ala Tyr Phe Leu Asp Gly Ser Leu Leu Lys Glu Thr Gly Thr Leu
            2180                2185                2190        
Glu Ser Gln Leu Glu Ala Asn Lys Arg Lys Gln Lys Glu Ile Gln Ala
        2195                2200                2205            
Met Lys Arg Gln Leu Thr Lys Ile Val Asp Leu Gly Asp Asn Leu Glu
    2210                2215                2220                
Asp Ala Leu Ile Leu Asp Ile Lys Tyr Ser Thr Ile Gly Leu Ala Gln
2225                2230                2235                2240
Gln Trp Asp Gln Leu Tyr Gln Leu Gly Leu Arg Met Gln His Asn Leu
                2245                2250                2255    
Glu Gln Gln Ile Gln Ala Lys Asp Ile Lys Gly Val Ser Glu Glu Thr
            2260                2265                2270        
Leu Lys Glu Phe Ser Thr Ile Tyr Lys His Phe Asp Glu Asn Leu Thr
        2275                2280                2285            
Gly Arg Leu Thr His Lys Glu Phe Arg Ser Cys Leu Arg Gly Leu Asn
    2290                2295                2300                
Tyr Tyr Leu Pro Met Val Glu Glu Asp Glu His Glu Pro Lys Phe Glu
2305                2310                2315                2320
Lys Phe Leu Asp Ala Val Asp Pro Gly Arg Lys Gly Tyr Val Ser Leu
                2325                2330                2335    
Glu Asp Tyr Thr Ala Phe Leu Ile Asp Lys Glu Ser Glu Asn Ile Lys
            2340                2345                2350        
Ser Ser Asp Glu Ile Glu Asn Ala Phe Gln Ala Leu Ala Glu Gly Lys
        2355                2360                2365            
Ser Tyr Ile Thr Lys Glu Asp Met Lys Gln Ala Leu Thr Pro Glu Gln
    2370                2375                2380                
Val Ser Phe Cys Ala Thr His Met Gln Gln Tyr Met Asp Pro Arg Gly
2385                2390                2395                2400
Arg Ser His Leu Ser Gly Tyr Asp Tyr Val Gly Phe Thr Asn Ser Tyr
                2405                2410                2415    
Phe Gly Asn
            


<210> 2723
<211> 856
<212> PRT
<213> Homo sapiens

<400> 2723
Met Gly Leu Val Ala Pro Val Gly Pro Ala Ser Pro Ala Ser Leu Trp
 1               5                  10                  15      
Pro Ala Ala Pro Gly Leu Leu Ser Leu Ala Pro Pro Arg Pro Thr Ala
            20                  25                  30          
Leu Ser Leu Cys His Gly Leu Arg Gly Arg Thr Arg Leu Glu Arg Glu
        35                  40                  45              
Ser Leu Arg Ala Gly Ala Pro Asp Ser Pro Trp Pro Leu Val Val Glu
    50                  55                  60                  
Ile Ala Pro Thr Ser Pro Thr Ser Arg Ser Arg Ala Asn Gly Arg Val
65                  70                  75                  80  
Arg Pro His Pro Pro Ser Leu Ala Phe Ala Pro Gln Gly Ser Asp Pro
                85                  90                  95      
Asp Arg Met Asp Arg Asp Tyr Gly Pro Gly Ser Tyr Gly Gly Leu Thr
            100                 105                 110         
Phe Lys Asp Ile Tyr Leu Lys Ile Leu Leu Leu Ser Ala Ser Lys Gly
        115                 120                 125             
Met Asp Arg Asp Tyr Gly His Gly Ser Tyr Gly Gly Gln Arg Ser Met
    130                 135                 140                 
Asp Ser Tyr Leu Asn Gln Ser Tyr Gly Met Asp Asn His Ser Gly Gly
145                 150                 155                 160 
Gly Gly Gly Ser Arg Phe Gly Pro Tyr Glu Ser Tyr Asp Ser Arg Ser
                165                 170                 175     
Ser Leu Gly Gly Arg Asp Leu Tyr Arg Ser Gly Tyr Gly Phe Asn Glu
            180                 185                 190         
Pro Glu Gln Ser Arg Phe Gly Gly Ser Tyr Gly Gly Arg Phe Glu Ser
        195                 200                 205             
Ser Tyr Arg Asn Ser Leu Asp Ser Phe Gly Gly Arg Asn Gln Gly Gly
    210                 215                 220                 
Ser Ser Trp Glu Ala Pro Tyr Ser Arg Ser Lys Leu Arg Pro Gly Phe
225                 230                 235                 240 
Met Glu Asp Arg Gly Arg Glu Asn Tyr Ser Ser Tyr Ser Ser Phe Ser
                245                 250                 255     
Ser Pro His Met Lys Pro Ala Pro Val Gly Ser Arg Gly Arg Gly Thr
            260                 265                 270         
Pro Ala Tyr Pro Glu Ser Thr Phe Gly Ser Arg Asn Tyr Asp Ala Phe
        275                 280                 285             
Gly Gly Pro Ser Thr Gly Arg Gly Arg Gly Arg Gly His Met Gly Asp
    290                 295                 300                 
Phe Gly Ser Ile His Arg Pro Gly Ile Val Val Asp Tyr Gln Asn Lys
305                 310                 315                 320 
Ser Thr Asn Val Thr Val Ala Ala Ala Arg Gly Ile Lys Arg Lys Met
                325                 330                 335     
Met Gln Pro Phe Asn Lys Pro Ser Gly Thr Phe Ile Lys Lys Pro Lys
            340                 345                 350         
Leu Ala Lys Pro Met Glu Lys Ile Ser Leu Ser Lys Ser Pro Thr Lys
        355                 360                 365             
Thr Asp Pro Lys Asn Glu Glu Glu Glu Lys Arg Arg Ile Glu Ala Arg
    370                 375                 380                 
Arg Glu Lys Gln Arg Arg Arg Arg Glu Lys Asn Ser Glu Lys Tyr Gly
385                 390                 395                 400 
Asp Gly Tyr Arg Met Ala Phe Thr Cys Ser Phe Cys Lys Phe Arg Thr
                405                 410                 415     
Phe Glu Glu Lys Asp Ile Glu Leu His Leu Glu Ser Ser Ser His Gln
            420                 425                 430         
Glu Thr Leu Asp His Ile Gln Lys Gln Thr Lys Phe Asp Lys Val Val
        435                 440                 445             
Met Glu Phe Leu His Glu Cys Met Val Asn Lys Phe Lys Lys Thr Ser
    450                 455                 460                 
Ile Arg Lys Gln Gln Thr Asn Asn Gln Thr Glu Val Val Lys Ile Ile
465                 470                 475                 480 
Glu Lys Asp Val Met Glu Gly Val Thr Val Asp Asp His Met Met Lys
                485                 490                 495     
Val Glu Thr Val His Cys Ser Ala Cys Ser Val Tyr Ile Pro Ala Leu
            500                 505                 510         
His Ser Ser Val Gln Gln His Leu Lys Ser Pro Asp His Ile Lys Gly
        515                 520                 525             
Lys Gln Ala Tyr Lys Glu Gln Ile Lys Arg Glu Ser Val Leu Thr Ala
    530                 535                 540                 
Thr Ser Ile Leu Asn Asn Pro Ile Val Lys Ala Arg Tyr Glu Arg Phe
545                 550                 555                 560 
Val Lys Gly Gln Lys Leu Asp Asn Lys Leu Gly Glu Arg Arg Asn Ala
                565                 570                 575     
Glu Gly Trp Lys Ala Arg Cys Asn Ala Phe Phe Leu Met Asn Pro Gln
            580                 585                 590         
Leu Gln Lys Lys Ser Glu Cys His Ser Tyr Tyr His Arg Gln Leu Trp
        595                 600                 605             
Ala Ala Ser Cys Ile Ser Gln Gly Asn Leu Glu Val His Ile Leu Lys
    610                 615                 620                 
Thr Glu Val Glu Lys Glu Leu Val Ile Gly Ser Gly Val His Gly Arg
625                 630                 635                 640 
Lys Pro Leu Thr Gly Ala His Asp Val Thr Trp Arg Glu Arg Gln Glu
                645                 650                 655     
Thr Glu Arg Gln Val Leu Asn Gly Ser Gln Phe Leu Leu Pro Asn Gly
            660                 665                 670         
Gln Leu Phe Ile Leu Asp Leu Gly Phe Phe Glu Glu Leu Asp Thr Ile
        675                 680                 685             
Gly Gln Cys Ile Met Ala Phe Thr Cys Ser Phe Cys Lys Phe Arg Thr
    690                 695                 700                 
Phe Glu Glu Lys Asp Ile Glu Leu His Leu Glu Ser Ser Ser His Gln
705                 710                 715                 720 
Glu Thr Leu Asp His Ile Gln Lys Gln Thr Lys Phe Asp Lys Val Val
                725                 730                 735     
Met Glu Phe Leu His Glu Cys Met Val Asn Lys Phe Lys Lys Thr Ser
            740                 745                 750         
Ile Arg Lys Gln Gln Thr Asn Asn Gln Thr Glu Val Val Lys Ile Ile
        755                 760                 765             
Glu Lys Asp Val Met Glu Gly Val Thr Val Asp Asp His Met Met Lys
    770                 775                 780                 
Val Glu Thr Val His Cys Ser Ala Cys Ser Val Tyr Ile Pro Ala Leu
785                 790                 795                 800 
His Ser Ser Val Gln Gln His Leu Lys Ser Pro Asp His Ile Lys Gly
                805                 810                 815     
Lys Gln Ala Tyr Lys Glu Gln Ile Lys Arg Glu Ser Val Leu Thr Ala
            820                 825                 830         
Thr Ser Ile Leu Asn Asn Pro Ile Val Lys Ala Arg Tyr Glu Arg Phe
        835                 840                 845             
Val Lys Val Ser Asp Met Tyr Pro
    850                 855     


<210> 2724
<211> 116
<212> PRT
<213> Homo sapiens

<400> 2724
Met Lys Ala Ala Ala Lys Val Val Glu Ser Lys Arg Ile Arg Thr Ile
 1               5                  10                  15      
Thr Ser Gln Asp Gln Pro Asn Gly Asn Asp Thr Glu Ile Glu Thr Glu
            20                  25                  30          
Ala Asn Leu Asp Thr Arg Lys Arg Ser His Lys Asn Leu Phe Leu Ser
        35                  40                  45              
Lys Leu Lys Leu Ile Ser Glu Ala Glu Lys Ala Lys Gln Lys Ile Ala
    50                  55                  60                  
Pro Val Phe Phe Arg Glu Glu Tyr Met Leu Asn Asn Ala Val Asp Phe
65                  70                  75                  80  
Ser Met Ala Glu Thr His Glu Leu Gln Glu Ala Leu Ile Lys Arg Asp
                85                  90                  95      
Arg Ser Gln Pro Ala Ala Val Asp Arg Ala Ser His Leu Arg Pro Leu
            100                 105                 110         
Ile Glu Lys Ser
        115     


<210> 2725
<211> 662
<212> PRT
<213> Homo sapiens

<400> 2725
Met Asp Asp Ala Val Met Asp Asn Val Lys Gln Ile Phe Gly Phe Glu
 1               5                  10                  15      
Ser Asn Lys Lys Asn Leu Val Asp Pro Phe Val Glu Val Ser Phe Ala
            20                  25                  30          
Gly Lys Met Leu Cys Ser Lys Ile Leu Glu Lys Thr Ala Asn Pro Gln
        35                  40                  45              
Trp Asn Gln Asn Ile Thr Leu Pro Ala Met Phe Pro Ser Met Cys Glu
    50                  55                  60                  
Lys Met Arg Ile Arg Ile Ile Asp Trp Asp Arg Leu Thr His Asn Asp
65                  70                  75                  80  
Ile Val Ala Thr Thr Tyr Leu Ser Met Ser Lys Ile Ser Ala Pro Gly
                85                  90                  95      
Gly Glu Ile Glu Glu Glu Pro Ala Gly Ala Val Lys Pro Ser Lys Ala
            100                 105                 110         
Ser Asp Leu Asp Asp Tyr Leu Gly Phe Leu Pro Thr Phe Gly Pro Cys
        115                 120                 125             
Tyr Ile Asn Leu Tyr Gly Ser Pro Arg Glu Phe Thr Gly Phe Pro Asp
    130                 135                 140                 
Pro Tyr Thr Glu Leu Asn Thr Gly Lys Gly Glu Gly Val Ala Tyr Arg
145                 150                 155                 160 
Gly Arg Leu Leu Leu Ser Leu Glu Thr Lys Leu Val Glu His Ser Glu
                165                 170                 175     
Gln Lys Val Glu Asp Leu Pro Ala Asp Asp Ile Leu Arg Val Glu Lys
            180                 185                 190         
Tyr Leu Arg Arg Arg Lys Tyr Ser Leu Phe Ala Ala Phe Tyr Ser Ala
        195                 200                 205             
Thr Met Leu Gln Asp Val Asp Asp Ala Ile Gln Phe Glu Val Ser Ile
    210                 215                 220                 
Gly Asn Tyr Gly Asn Lys Phe Asp Met Thr Cys Leu Pro Leu Ala Ser
225                 230                 235                 240 
Thr Thr Gln Tyr Ser Arg Ala Val Phe Asp Gly Cys His Tyr Tyr Tyr
                245                 250                 255     
Leu Pro Trp Gly Asn Val Lys Pro Val Val Val Leu Ser Ser Tyr Trp
            260                 265                 270         
Glu Asp Ile Ser His Arg Ile Glu Thr Gln Asn Gln Leu Leu Gly Ile
        275                 280                 285             
Ala Asp Arg Leu Glu Ala Gly Leu Glu Gln Val His Leu Ala Leu Lys
    290                 295                 300                 
Ala Gln Cys Ser Thr Glu Asp Val Asp Ser Leu Val Ala Gln Leu Thr
305                 310                 315                 320 
Asp Glu Leu Ile Ala Gly Cys Ser Gln Pro Leu Gly Asp Ile His Glu
                325                 330                 335     
Thr Pro Ser Ala Thr His Leu Asp Gln Tyr Leu Tyr Gln Leu Arg Thr
            340                 345                 350         
His His Leu Ser Gln Ile Thr Glu Ala Ala Leu Ala Leu Lys Leu Gly
        355                 360                 365             
His Ser Glu Leu Pro Ala Ala Leu Glu Gln Ala Glu Asp Trp Leu Leu
    370                 375                 380                 
Arg Leu Arg Ala Leu Ala Glu Glu Pro Gln Asn Ser Leu Pro Asp Ile
385                 390                 395                 400 
Val Ile Trp Met Leu Gln Gly Asp Lys Arg Val Ala Tyr Gln Arg Val
                405                 410                 415     
Pro Ala His Gln Val Leu Phe Ser Arg Arg Gly Ala Asn Tyr Cys Gly
            420                 425                 430         
Lys Asn Cys Gly Lys Leu Gln Thr Ile Phe Leu Lys Tyr Pro Met Glu
        435                 440                 445             
Lys Val Pro Gly Ala Arg Met Pro Val Gln Ile Arg Val Lys Leu Trp
    450                 455                 460                 
Phe Gly Leu Ser Val Asp Glu Lys Glu Phe Asn Gln Phe Ala Glu Gly
465                 470                 475                 480 
Lys Leu Ser Val Phe Ala Glu Thr Tyr Glu Asn Glu Thr Lys Leu Ala
                485                 490                 495     
Leu Val Gly Asn Trp Gly Thr Thr Gly Leu Thr Tyr Pro Lys Phe Ser
            500                 505                 510         
Asp Val Thr Gly Lys Ile Lys Leu Pro Lys Asp Ser Phe Arg Pro Ser
        515                 520                 525             
Ala Gly Trp Thr Trp Ala Gly Asp Trp Phe Val Cys Pro Glu Lys Thr
    530                 535                 540                 
Leu Leu His Asp Met Asp Ala Gly His Leu Ser Phe Val Glu Glu Val
545                 550                 555                 560 
Phe Glu Asn Gln Thr Arg Leu Pro Gly Gly Gln Trp Ile Tyr Met Ser
                565                 570                 575     
Asp Asn Tyr Thr Asp Val Asn Gly Glu Lys Val Leu Pro Lys Asp Asp
            580                 585                 590         
Ile Glu Cys Pro Leu Gly Trp Lys Trp Glu Asp Glu Glu Trp Ser Thr
        595                 600                 605             
Asp Leu Asn Arg Ala Val Asp Glu Gln Ala Gly Ser Ile Ala Ser Pro
    610                 615                 620                 
Ser Pro Arg Ser Gly Ser Arg Ser Thr Gly Ser Leu Leu Arg Arg Cys
625                 630                 635                 640 
Thr Thr His Thr Asp Gly Gly Ala Gly Cys Ala Cys Ala Gly Gly Ile
                645                 650                 655     
Ser Ala Lys Trp Lys His
            660         


<210> 2726
<211> 329
<212> PRT
<213> Homo sapiens

<400> 2726
Met Thr Pro Phe Val Gly Gln Lys Val Leu His Leu Val Asn Ile Gln
 1               5                  10                  15      
Met Asp Val Lys Lys Glu Leu Glu Gln Thr Cys Ser Asp Val Val Gly
            20                  25                  30          
Gly Arg Lys Arg Cys Phe Ser Asp Glu Trp Arg Leu Gly Thr Ser Ala
        35                  40                  45              
Glu Met Val Leu Leu Asn His Thr Ala Ser Val Leu Cys His Ser Met
    50                  55                  60                  
Lys Gly Arg Gln Glu Cys Arg Ser Phe Pro Met Pro Pro Asp Lys Leu
65                  70                  75                  80  
Gln Gly Leu Leu Arg Ser Ala Leu Asp Val Ser Ser Leu Val Lys Ala
                85                  90                  95      
Lys Gly Phe His Arg Lys Arg Ala Arg Pro Trp Arg Ala Tyr Pro Glu
            100                 105                 110         
Pro Phe Met Gly Ser Arg Thr Gln Leu Leu Gln Tyr Pro Phe Ile Pro
        115                 120                 125             
Asn His Leu Ser Thr Pro Pro Pro Phe Ile Phe Ser Ala Leu Leu Asn
    130                 135                 140                 
Ile Ser Asn Thr Trp Tyr Thr Ser Ile Leu Leu Ile Pro Ser Pro Asn
145                 150                 155                 160 
Asp Leu Ala Ile Ser His Ile Gln Lys Gly Gln Leu Trp Arg Thr Thr
                165                 170                 175     
Val Lys Asn Ala Arg Leu Ser Lys Asp Glu Asn Ser Leu Asn Ile Tyr
            180                 185                 190         
Tyr Ser Gly Lys Ser Lys Lys Leu Gly Thr Thr Gly Ser Gly Met Ala
        195                 200                 205             
Gly Cys Gly Gln Ala Gly Glu Pro Gly Gly Arg Glu Ser Arg Arg Asp
    210                 215                 220                 
Pro Thr Val Pro Ala Glu Ser Val His Pro Gly Glu Ile Leu Thr Gln
225                 230                 235                 240 
Asp Pro Arg Gly Thr Leu Leu Arg Ile Leu Thr Phe Val Leu Leu Glu
                245                 250                 255     
Val Leu Arg Asn Ala Val Asn Pro Leu Ala Gln Gly Ala Ala Asn Phe
            260                 265                 270         
Ile Tyr Lys Arg Ser Lys Ser Arg Glu Pro Glu Ala Leu Leu Gln Tyr
        275                 280                 285             
Ser Thr Leu Ser His Ser Thr Asp Arg Ser Pro Ile Asp Met Met Gln
    290                 295                 300                 
Met Ser Gly His Gly Cys Asp Leu Thr Arg Cys His Leu Gln Asn Gln
305                 310                 315                 320 
Ala Val Gly Trp Val Trp Pro Leu Leu
                325                 


<210> 2727
<211> 857
<212> PRT
<213> Homo sapiens

<400> 2727
Met Glu Pro Asp Gly Gly Asn Arg Pro Pro Pro Leu Arg Thr Arg Pro
 1               5                  10                  15      
Gly His Pro Pro Val Pro Pro Thr Gly Pro Val Lys Val Thr Gly Leu
            20                  25                  30          
Val Leu Val Ser Pro Lys His Gln Leu Leu Lys Leu Leu Lys Glu Gly
        35                  40                  45              
Glu Glu Ser Lys Glu Asp Cys Glu Glu Arg Ser Leu Ser Cys His Val
    50                  55                  60                  
Gly Lys Leu Gly Cys Lys Thr Ser Gln Ser Thr Glu Val Ser Ile Arg
65                  70                  75                  80  
Lys Ile Pro Ala Ser Gln Arg Arg Cys His Arg Lys Gln Lys Ser Lys
                85                  90                  95      
His Thr Ser Gln Arg Gln Val Pro Thr Leu Glu Asn Pro Val Ser Leu
            100                 105                 110         
Thr Ile Lys Gly Thr Val Leu Thr Gly Ile Ala Ala Ser Arg Tyr Trp
        115                 120                 125             
Asn Val Glu Gly Ile Thr Arg Pro Arg Leu Ala Val Gly Pro Gly Tyr
    130                 135                 140                 
Gly Val Ser Glu Pro Gly Arg Gln His Ser Ala Cys Arg Ala Gly Ile
145                 150                 155                 160 
Leu Asp Ser Arg Leu Pro Glu Arg Gln Trp Leu Leu Gln Asn Cys His
                165                 170                 175     
Gly Ala Thr Gly Ser Trp Gly Arg Gln Gln Gly Pro Cys Ile Asn His
            180                 185                 190         
His Val Leu Asp Val Ser Val Ile Pro Leu Tyr Asn Ile Ser Gly Pro
        195                 200                 205             
Glu Pro Pro Lys Trp Lys Arg Glu Ala Gly Thr Ser Pro Thr Gly Leu
    210                 215                 220                 
Glu Arg Pro Val Leu Ser Ala Ala Pro Pro Ser Gln Val Arg Lys Ser
225                 230                 235                 240 
Pro Gln Ile Thr Gly Cys Ser Leu Ile Cys Ser Pro His Pro Gly Phe
                245                 250                 255     
Pro Ala His Thr Ser Arg Leu Val Asn Ala Glu Val Pro Met Met Arg
            260                 265                 270         
Ala Ala Gly Arg Gly Trp Gly His Glu Gln Met Pro Trp Pro Arg Arg
        275                 280                 285             
Lys Ser Ala Asp Thr Val Ser Leu Gln Lys Gly Glu Val Pro Arg Pro
    290                 295                 300                 
Gly His Gly Val Thr Lys Ser His Pro Gly Arg Ala Leu Arg Ala Ser
305                 310                 315                 320 
Pro Glu Pro Asn Pro Arg Leu Trp Phe Glu His Ser Gln Leu Leu His
                325                 330                 335     
Gly Ser Pro Lys Ala Phe Val Phe Val His Gln Leu Ser Val Asn Met
            340                 345                 350         
Leu Tyr Arg Leu Leu Val Ser Lys Thr Ala Asn Asn Ser Ser Gln His
        355                 360                 365             
Val Pro Asp Met Ala Asp Asn Ala Val Cys Asn Thr Ser Ser Pro His
    370                 375                 380                 
Leu Asp Thr Arg Gln Trp Cys Ser Gln Pro Pro Ser Gln Gln Ser Ile
385                 390                 395                 400 
Asp Glu Val Ala Ser Asn Gln Arg Gly Lys Pro Thr Ser Thr Val Ile
                405                 410                 415     
Val Leu Cys Val Val Phe Ser Ile Ser Ser Pro Ala Pro Ala Pro Gly
            420                 425                 430         
Pro Pro Pro Leu Thr Met Ser Pro Cys Pro Gly Pro Ser Val Asn Gly
        435                 440                 445             
Pro His Phe Thr Ser Leu Lys Ala Phe Arg Lys Pro Leu Ser Pro Arg
    450                 455                 460                 
Pro Pro Gly Ile Asn Glu Thr Ile Arg Leu Pro Ser Arg Arg Gly Trp
465                 470                 475                 480 
Arg Asp Val Ser Thr Val Cys Leu Lys Leu Ser Lys Ala Gln Thr Pro
                485                 490                 495     
Gly Pro Ala Thr Arg Gln Leu Asn Lys Asp Thr Gln Ser Gln Cys Gln
            500                 505                 510         
Gly Ile Leu Arg His Gln Lys Ile Ser Pro Gln Ile Leu Lys Asn Lys
        515                 520                 525             
Ser His Gln Ser Pro Gln Val Phe Ala Asp Leu Pro Thr Ser Leu Glu
    530                 535                 540                 
Gly Ala Ala Ser Leu Ser Asp Pro Ser Ile Leu Pro Ser Ser Cys Pro
545                 550                 555                 560 
Ala Gln Gln Arg Phe Met Asp Ser Cys Gly Val Gln Gly Thr Val Arg
                565                 570                 575     
Pro Trp Tyr His Asn Glu Leu Gly Gly Glu Arg Pro Leu Glu Ser Ser
            580                 585                 590         
Ser Ala Thr Ile Ser Pro Asn His Ile Leu Ser Thr Ser Gln Ala Cys
        595                 600                 605             
Ile Thr Glu Val Leu Glu Phe Glu Ser Ser Thr His Asp Val Arg Thr
    610                 615                 620                 
Val Gln Arg Ser Glu Gly Leu Glu Leu Arg Lys Glu Ala Leu Trp Thr
625                 630                 635                 640 
Lys Pro Leu Lys Thr Trp Leu Gly Ala Gly Arg Ser Pro Arg Gly Ala
                645                 650                 655     
Ala Arg Thr Leu Gln Ser Arg Pro Leu Glu Gln Phe Ser Pro Arg Arg
            660                 665                 670         
Arg Leu Pro Ser Arg Trp Glu Ser Met Gln Pro Ser His Gly Lys Ser
        675                 680                 685             
Ala Met Val Leu Lys Leu Cys Pro Gln Arg Asn Thr Cys Ala Leu Thr
    690                 695                 700                 
Leu Glu Trp Thr Ser Gly Glu Trp Lys Gly Gln Gln Val Arg Ser Gln
705                 710                 715                 720 
Lys Asp Pro Gly Leu Gln Val Arg Ser Gln Lys Asp Pro Gly Leu Gln
                725                 730                 735     
Val Arg Ser Gln Lys Asp Pro Gly Leu Gln Val Arg Ser Gln Lys Asp
            740                 745                 750         
Pro Gly Leu Gln Val Arg Ser Gln Lys Asp Pro Gly Leu Gln Val Arg
        755                 760                 765             
Ser Gln Lys Asp Pro Gly Leu Gln Val Arg Ser Gln Lys Asp Pro Gly
    770                 775                 780                 
Leu Gln Val Arg Ser Gln Lys Asp Pro Gly Leu Gln Ser Pro Leu Pro
785                 790                 795                 800 
Val Ser Met Leu Lys Gly Gly Arg Arg Gln Cys Leu Ile Glu Cys Arg
                805                 810                 815     
Ile Met Asn Pro Ile Val Leu Asp Leu Leu His His His Cys Val Val
            820                 825                 830         
Arg Val Pro Pro Glu Ala Lys His Pro Asp Phe Arg His Pro Ser Ser
        835                 840                 845             
Arg Ala Ser Ala Lys Pro Arg Ser Glu
    850                 855         


<210> 2728
<211> 285
<212> PRT
<213> Homo sapiens

<400> 2728
Met Ser Arg Ala Leu Asp Val Leu Pro Met Lys Glu Glu Asp Val Leu
 1               5                  10                  15      
Lys Phe Leu Ser Ala Gly Thr His Leu Gly Gly Thr Asn Leu Asp Phe
            20                  25                  30          
Gln Met Glu Gln Tyr Ile Tyr Met Lys Ser Asp Gly Ile Tyr Ile Leu
        35                  40                  45              
Asn Gln Lys Lys Thr Trp Glu Lys Phe Leu Leu Ala Ala His Ala Ile
    50                  55                  60                  
Val Val Ile Glu Ile Pro Ala Asp Val Ser Val Ile Ser Ser Arg Lys
65                  70                  75                  80  
Thr Gly Gln Lys Gly Thr Pro Ile Leu Ala Ala Val Thr Gly Ala Thr
                85                  90                  95      
Leu Val Thr Gly Cys Phe Thr Pro Arg Ile Phe Thr Asn Gln Ile Gln
            100                 105                 110         
Ala Ala Phe Gln Glu Pro Trp Leu Leu Ala Asp His Gln Pro Leu Thr
        115                 120                 125             
Glu Ala Ser Tyr Val Asn Leu Pro Thr Ile Ala Leu Cys His Thr Asp
    130                 135                 140                 
Ser Pro Leu Cys Tyr Val Glu Val Val Ile Pro Cys Asn Asn Lys Gly
145                 150                 155                 160 
Ala His Ser Gly Gly Leu Thr Trp Trp Met Leu Ala Gln Lys Val Leu
                165                 170                 175     
His Met Pro Gly Thr Ile Ser His Lys His Pro Trp Asp Val Met Pro
            180                 185                 190         
Asp Phe Tyr Ile Cys Arg Asp Pro Glu Glu Met Glu Lys Asp Gln Ala
        195                 200                 205             
Ala Ala Glu Lys Ala Val Thr Asn Glu Glu Phe Gln Asp Glu Arg Thr
    210                 215                 220                 
Met Pro Ala Pro Glu Leu Ser Ala Thr Gln Ser Glu Gly Ala Asp Trp
225                 230                 235                 240 
Ser Glu Gly Thr Cys Arg Cys Pro Leu Cys Leu Phe Ser Ser Ser Leu
                245                 250                 255     
Leu Lys Pro Gly Pro Ala Thr Gly Gly Trp Cys Ala Ala Pro Thr Ala
            260                 265                 270         
Pro Ala Thr Glu Trp Val Glu Ala Thr Thr Glu Trp Ser
        275                 280                 285 


<210> 2729
<211> 200
<212> PRT
<213> Homo sapiens

<400> 2729
Met His Leu Trp Gly Arg Arg Lys Gln Ala Ser Lys Gln Gly Ala Asn
 1               5                  10                  15      
Val Thr Ala Lys Pro Pro Ala Tyr Gly Phe Gln Pro Pro Gln Ile Pro
            20                  25                  30          
Ala His Ser Pro Ala Gly Leu Pro Pro Glu Arg Ser Pro Arg Ala Leu
        35                  40                  45              
Gly Leu Ala Glu Gly Ala Leu Leu Glu Arg Gly Gly Pro Ser Asp Ser
    50                  55                  60                  
Ala Ala Gln Thr Pro Pro Pro Ser Leu Pro Pro Arg Pro Val Ser Glu
65                  70                  75                  80  
Leu Asp Trp Val Pro Thr Ser Ser Gln Lys Val Lys Val Ser Lys Ser
                85                  90                  95      
Gly Ala Ala Val Ser Val Glu Trp Cys Val Gln Arg Ala Ala Arg Ala
            100                 105                 110         
Met His Cys Ala Gly Leu Ala Gly Ala Ala His Ala Arg Ser Ser Arg
        115                 120                 125             
Ala Ala Arg Lys Leu Leu Met Gln Gly Ala Ala Met Gln Glu Leu Lys
    130                 135                 140                 
Gln Arg Ala Ala Leu Ala Val Leu Trp Ala Pro Cys Gly Met Gln Cys
145                 150                 155                 160 
Arg Asn Gln Pro Val Gln His Ala Cys Gln Ser Gly Ser Ser Pro Thr
                165                 170                 175     
Leu Pro Leu Gly Lys Pro Thr Pro Ile Leu Thr Gly Met Ala Ala Gly
            180                 185                 190         
Gly Leu Pro Lys Pro Asn Leu Ser
        195                 200 


<210> 2730
<211> 451
<212> PRT
<213> Homo sapiens

<400> 2730
Met Gly Pro Ser Arg Leu Pro Gln Leu Cys Ile Gln Pro Asp Val Ala
 1               5                  10                  15      
Leu Cys Trp Ala Ala Val Gln Ser Asp Arg Gln Asn Ala Val Tyr Lys
            20                  25                  30          
Gly Val Glu Thr Asp Asn Arg Trp Gln Leu Ser Thr Ser Trp Arg Leu
        35                  40                  45              
Gln Arg Gly Val Ala Asp Tyr Leu Ala Phe Gly Asn Arg Ala Leu Leu
    50                  55                  60                  
Pro Ala Gly Gly Pro Gln Pro Trp Ala Val Pro Glu Gly Ser Ser Glu
65                  70                  75                  80  
Met Met Arg Val Gln Lys Gly Lys Leu Glu Val Ile Val Gly Leu Leu
                85                  90                  95      
Leu Thr Asp Glu Glu Ile Glu Ser Thr Leu Lys Met Lys Ser Pro Leu
            100                 105                 110         
Tyr Gln Asn Leu Asn Ser Pro Pro Thr Val Ile Cys Val Ser Pro Glu
        115                 120                 125             
Thr Phe Gly Leu Ser Val His Gly Ala Pro Ala Ser Ser Thr Tyr Ile
    130                 135                 140                 
Leu Thr Leu Phe Pro Gly Thr Pro His Ser Leu Phe Pro Leu Ala Thr
145                 150                 155                 160 
Pro Gly Ala Ser Pro Asp Ile Gly Ser Pro Ser Leu Gln Gly Pro Gln
                165                 170                 175     
Leu Lys Asn Pro Gly Asn Lys Gly Arg Ser Gln Ile Cys Ile Val Gln
            180                 185                 190         
Ser Ser Ala Asp Ala Leu Pro Ser Ser Arg Cys Thr Asn Pro Ser Ser
        195                 200                 205             
Thr Phe Thr Ser Leu Gln Ser Ala Leu Arg Ser Ser Trp Ala His Pro
    210                 215                 220                 
His Ser Phe Leu Thr Leu Asn Pro Asn Ala His Pro Glu Lys Gln Gln
225                 230                 235                 240 
Pro Ser Val Gly Ala Gly Ala Thr Asn Glu Ala Leu Ile Pro Gln Leu
                245                 250                 255     
Thr Tyr Glu Lys Phe Leu Ile Ile Arg Asp Phe Ile Leu Val Asn Pro
            260                 265                 270         
Val Asp Pro Leu Trp Met Val Cys Gln Gly Leu Leu Gly Leu Leu Leu
        275                 280                 285             
Val Glu Glu Cys Pro Glu Ala Met Leu Glu Val Thr Ser His Ser Leu
    290                 295                 300                 
Thr Leu Leu Ser Pro Thr Asp Ala His Gln Ala Ala Glu Thr Gly Thr
305                 310                 315                 320 
Cys Gly Gly Leu Thr Val Arg Ser Ser Val Gln Val Leu Ser Ile Leu
                325                 330                 335     
Phe Ala Gly Pro His Ala Cys Arg Ala Pro Pro Gln Lys Ala Gly Pro
            340                 345                 350         
Asp Ser Asp Gln Gln Gly Leu Gln Gly Arg Ser Ala Gly Leu Arg Gln
        355                 360                 365             
Arg Leu Gly Arg Arg Leu Gly Val Ala Gly Glu Pro Leu His Val Leu
    370                 375                 380                 
Pro Phe Ser Arg Val His Gly Ala Leu Glu Ala Gln Met Leu Ala Lys
385                 390                 395                 400 
Trp Arg Glu Arg Ser Arg Asp Glu Asp Ser Gly Gly Ile Pro Ala Ile
                405                 410                 415     
Ser Ser Thr Leu Arg Ala Gln Leu Pro Val Glu Gln Ala Gly Arg Ala
            420                 425                 430         
Leu Arg Val Gly Arg Gly Glu Gly Trp Gly Leu Pro Lys Thr Ala Pro
        435                 440                 445             
Cys Thr Asp
    450     


<210> 2731
<211> 105
<212> PRT
<213> Homo sapiens

<400> 2731
Met Asn Ser Asn Cys Leu Leu Gln Ala Met Lys Thr Gln Val Ala Val
 1               5                  10                  15      
Val Ser Asp Gly Gly Ile Leu Arg Ala Leu Ser Leu Lys Glu Leu Ile
            20                  25                  30          
Gly Asn Arg Met Met Ser Pro Pro Trp Val Lys Pro Arg Arg Pro Gln
        35                  40                  45              
Phe Ala Asp Met Asp Glu Ile Phe Ser Val Arg Leu Ser Leu Met Asp
    50                  55                  60                  
Tyr Asp Ser Arg Gly His Gln Leu Gly Val Phe Lys Gly Val Trp Phe
65                  70                  75                  80  
Val Gly Val Asp Thr Gly Leu Arg Gln Lys Trp Asp Gly Ser Gln Ala
                85                  90                  95      
Met Thr Gly Gln Phe Thr Trp Leu Met
            100                 105 


<210> 2732
<211> 91
<212> PRT
<213> Homo sapiens

<400> 2732
Met Ala Cys Gln Phe Leu Phe Tyr Ser Val Asn Val His Ser Ser His
 1               5                  10                  15      
Val Gly Gly Arg Cys His His Thr His Phe Thr Asp Glu Asn Thr Glu
            20                  25                  30          
Pro Leu Arg Phe Asn Asn Leu Ser Lys Leu Ala Gln Leu Glu Asp Gly
        35                  40                  45              
Arg Ala Arg Thr Gly Pro Arg Val Val Arg Leu Glu Asn Pro Gly Pro
    50                  55                  60                  
Ile Cys Cys Thr Lys Leu Lys Gly Gln Glu Glu Glu Arg Lys Arg Arg
65                  70                  75                  80  
Asp Asn Ser Val Pro Glu Val Ser Val Leu Asp
                85                  90      


<210> 2733
<211> 137
<212> PRT
<213> Homo sapiens

<400> 2733
Met Trp Val Tyr Leu Arg Leu Thr Val Ser Arg Asp Arg Gln Ser Asn
 1               5                  10                  15      
Gly Cys Ile Glu Ala Leu Leu Leu Gly Ile Tyr Asn Leu Glu Ile Ala
            20                  25                  30          
Asp Lys Asp Gly Asn Asn Lys Val Leu Ser Phe Thr Ile Pro Ser Leu
        35                  40                  45              
Ser Lys Pro Ser Ile Tyr His Glu Pro Ser Thr Ile Gly Ser Met Ala
    50                  55                  60                  
Leu Thr Glu Gly Ala Leu Cys Gln His Asp Leu Ile Arg Val Val Tyr
65                  70                  75                  80  
Ser Asp Leu His Pro Gln Arg Glu Thr Phe Thr Ala Gln Asn Arg Phe
                85                  90                  95      
Glu Val Leu Ser Phe Leu Met Leu Cys Tyr Asn Ser Ala Ile Val Tyr
            100                 105                 110         
Met Pro Ala Ser Ser Tyr Gln Ser Leu Cys Arg Met Gly Ser Arg Gly
        115                 120                 125             
Leu Cys Glu Trp Leu Ser Thr Ala Thr
    130                 135         


<210> 2734
<211> 684
<212> PRT
<213> Homo sapiens

<400> 2734
Met Arg Ala Glu Lys Arg Lys Lys Asn Ala Pro Glu Glu Val Ser Arg
 1               5                  10                  15      
Leu Lys Ser Ile Leu Lys Leu Asp Asp Asp Val Leu Met Lys Asp Val
            20                  25                  30          
Gln Glu Ile Ala Thr Val Val Val Pro Lys Pro Lys His Cys Gln Glu
        35                  40                  45              
Lys Met Gln Cys Glu Val Lys Asp Glu Lys Asp Asp Met Lys Met Glu
    50                  55                  60                  
Thr Asp Ile Lys Arg Asn Lys Lys Thr Leu Leu Asp Gln His Gly Gln
65                  70                  75                  80  
Tyr Pro Ile Trp Met Asn Gln Arg Gln Arg Lys Arg Leu Lys Ala Lys
                85                  90                  95      
Arg Glu Lys Arg Lys Glu Lys Asn Lys Ala Lys Ala Val Lys Val Ala
            100                 105                 110         
Lys Gly Leu Ala Cys Ser Ile Val Ser Ile Ile Val His Phe Ala Glu
        115                 120                 125             
Ile Arg Arg Arg Ile Lys Leu Arg Glu Lys Glu Glu Ala Lys Arg Gly
    130                 135                 140                 
Lys Val Val Ala Thr Cys Arg Asn Leu Lys Asn Met Cys Asp Lys Ala
145                 150                 155                 160 
Ala Ile Ile Ser Ala Ser Arg Ala Ala Ala Ala Arg Leu Arg Gly Thr
                165                 170                 175     
Ala Ala Ser Pro Gly Pro Thr Ala Ala Arg Gln Gln Asp Gly Trp Asn
            180                 185                 190         
Gly Leu Ser His Glu Ala Phe Arg Ile Val Ser Arg Gln Asp Tyr Ala
        195                 200                 205             
Ser Glu Ala Ile Asn Gly Ala Ala Gly Gly Val Tyr Leu Gly Thr Thr
    210                 215                 220                 
Asn Ser Cys Val Ala Val Met Glu Gly Lys Gln Ala Lys Val Leu Glu
225                 230                 235                 240 
Asn Ala Glu Gly Ala Arg Thr Thr Pro Ser Val Val Ala Phe Thr Ala
                245                 250                 255     
Asp Val Gln Lys Asp Ile Lys Asn Ile Pro Phe Lys Ile Val Cys Ala
            260                 265                 270         
Ser Asn Gly Asp Ala Trp Val Glu Ala His Gly Lys Leu Tyr Ser Pro
        275                 280                 285             
Ser Gln Ile Gly Ala Phe Val Ser Met Lys Met Lys Glu Thr Ala Glu
    290                 295                 300                 
Asn Tyr Leu Gly His Thr Ala Lys Asn Ala Val Ile Ala Val Pro Ala
305                 310                 315                 320 
Tyr Phe Asn Asp Leu Gln Arg Gln Ala Thr Lys Asp Ala Gly Gln Ile
                325                 330                 335     
Ser Gly Leu Asn Val Leu Arg Val Ile Asn Glu Pro Thr Ala Ala Ala
            340                 345                 350         
Leu Ala Tyr Gly Leu Asp Lys Ser Lys Asp Lys Val Ile Ala Val Tyr
        355                 360                 365             
Asp Leu Gly Gly Gly Thr Phe Asp Ile Ser Ile Leu Glu Phe Gln Lys
    370                 375                 380                 
Gly Val Phe Glu Val Lys Ser Thr Asn Gly Asp Thr Phe Leu Gly Gly
385                 390                 395                 400 
Glu Asp Phe Asp Gln Ala Leu Leu Gln His Ile Val Lys Glu Phe Lys
                405                 410                 415     
Arg Glu Thr Gly Val Asp Leu Thr Lys Asp Asn Val Ala Phe Gln Arg
            420                 425                 430         
Val Trp Glu Ala Ala Glu Lys Ala Lys Cys Glu Leu Ser Ser Ser Val
        435                 440                 445             
Gln Thr Asp Ile Asn Leu Pro Tyr Leu Thr Met Asp Ser Ser Gly Pro
    450                 455                 460                 
Lys His Leu Asn Thr Lys Leu Thr His Ala Gln Phe Glu Gly Ile Val
465                 470                 475                 480 
Thr Asp Leu Ile Arg Arg Thr Ile Ala Pro Cys Gln Lys Ala Met Gln
                485                 490                 495     
Asp Ala Glu Val Ser Lys Ser Asp Ile Gly Glu Val Ile Leu Val Glu
            500                 505                 510         
Pro Pro Ser Lys Ala Val Asn Pro Asp Glu Ala Val Ala Ile Gly Ala
        515                 520                 525             
Ala Ile Gln Gly Asp Val Leu Ala Gly Asp Val Thr Asp Val Leu Leu
    530                 535                 540                 
Leu Asp Val Ile Pro Leu Ser Leu Gly Ile Glu Thr Leu Arg Gly Val
545                 550                 555                 560 
Phe Thr Lys Leu Ile Asn Arg Asn Thr Thr Ile Pro Thr Lys Lys Ser
                565                 570                 575     
Gln Val Phe Ser Thr Ala Ala Asp Gly Gln Thr Gln Val Glu Ile Lys
            580                 585                 590         
Val Cys Gln Gly Glu Arg Glu Met Ala Gly Asp Asn Lys Leu Leu Gly
        595                 600                 605             
Gln Phe Thr Leu Ile Gly Ile Pro Pro Ala Pro Arg Gly Val Pro Gln
    610                 615                 620                 
Ile Lys Val Thr Phe Asp Ile Asp Ala Asn Gly Ile Ile His Val Ser
625                 630                 635                 640 
Ala Lys Asp Lys Gly Thr Gly His Glu Gln Gln Ile Val Ile Gln Ser
                645                 650                 655     
Ser Gly Gly Leu Ser Lys Asp Asp Val Glu Asn Met Val Lys Asn Ala
            660                 665                 670         
Glu Lys Tyr Ala Lys Glu Asp Gln Arg Arg Lys Glu
        675                 680                 


<210> 2735
<211> 232
<212> PRT
<213> Homo sapiens

<400> 2735
Met Ser Lys Ser Gly Glu Gly Arg Thr Gly Tyr Asn Ala Glu Gln Asn
 1               5                  10                  15      
Leu Thr Pro Gly Ile Glu Ser Lys Met Gln Asn Ile Ala Val Val Thr
            20                  25                  30          
Glu Leu Asn Ile Asp Asp Ser Ser Asp Phe Asp Gln Lys Pro Cys Tyr
        35                  40                  45              
Leu Lys Thr Tyr Pro Lys His Lys Val Leu Asn Thr Thr Leu Phe Glu
    50                  55                  60                  
Ser Trp Glu Ile Val Gly Pro Tyr Pro Ser Trp Trp Val Phe Asn Leu
65                  70                  75                  80  
Leu Leu Leu Leu Val Gln Gly Leu Asn Cys Phe Trp Ser Tyr Leu Ile
                85                  90                  95      
Val Lys Ile Ala Cys Lys Ala Val Ser Arg Gly Lys Val Ser Lys Asp
            100                 105                 110         
Asp Arg Ser Asp Ile Glu Ser Ser Ser Asp Glu Glu Asp Ser Glu Pro
        115                 120                 125             
Pro Gly Lys Asn Pro His Thr Ala Thr Thr Thr Asn Gly Thr Ser Gly
    130                 135                 140                 
Thr Asn Gly Gly His Ser Val Ala Ala Glu Lys Ala Cys Pro Arg Gly
145                 150                 155                 160 
Cys Trp Asn Pro Ser Asn Lys Tyr Leu Glu Asp Arg Ala Glu Gln Ile
                165                 170                 175     
Ser Leu Leu Gly Glu Gly Ile Thr Val Ala Arg Ser Gly Met Met Gly
            180                 185                 190         
Ala Lys Leu Gly Met Glu Met Ser Ala Gln Glu Asp Ser Ala Ala Gly
        195                 200                 205             
Arg Ile Val Ala Gln Gly Gly Gly Glu Glu Glu Ser Thr Gln Gly Gly
    210                 215                 220                 
Ser Glu Glu Leu Glu Glu Glu Ala
225                 230         


<210> 2736
<211> 103
<212> PRT
<213> Homo sapiens

<400> 2736
Met Val Phe Leu Leu Gly Gly Thr Gly Ala Val Glu Glu Ala Gly Leu
 1               5                  10                  15      
Gly Leu Val Arg Val Asn Val Phe Ser Gly Leu Trp Leu Ser Gly Thr
            20                  25                  30          
Trp Pro Gly Val Met Arg Val Asp Arg Gly Pro Glu Gly Glu Ser Leu
        35                  40                  45              
Ile Pro Arg Ala Val Gly Gly Val Gly Arg Leu Arg Ala Gly Trp Phe
    50                  55                  60                  
Gly Lys His Val Cys Gly Pro Val Gly Tyr Arg Leu Lys Glu Trp Ala
65                  70                  75                  80  
Arg Pro Gly Cys Gly Cys Pro Ser Arg Ile Ser Lys Ala Ala Asn Ile
                85                  90                  95      
Lys Ala Pro Glu Tyr Thr Lys
            100             


<210> 2737
<211> 97
<212> PRT
<213> Homo sapiens

<400> 2737
Met Leu Asn Pro Gln Met Gly Lys Ala Ile Gln Val Ile Pro Pro Leu
 1               5                  10                  15      
His Ser Ser Arg Ile Pro Asn Lys Leu Leu Phe Ala Ser Glu Met Met
            20                  25                  30          
Gly Arg Arg Arg Val Met Pro Ser Gly Thr Tyr Val Leu Ile Gly Gln
        35                  40                  45              
Arg Trp His Tyr Trp Glu His Gly Ile Leu Val Phe Pro Val Gly Ile
    50                  55                  60                  
Ser Lys Glu Lys His Arg Ala Pro Lys Glu Ala Ala Ala Leu Met Glu
65                  70                  75                  80  
Gln Thr Val Pro Leu Thr Ser Glu Lys Asn His Ser Thr Val Ser Arg
                85                  90                  95      
Gly
    


<210> 2738
<211> 56
<212> PRT
<213> Homo sapiens

<400> 2738
Met Cys Leu Gln Ile Gly Tyr Pro Ala Val Ala Ser Val Pro His Phe
 1               5                  10                  15      
Ile Ile Asn Gly Tyr Lys Glu Val Leu Ala Leu Ser Val Glu Thr Asp
            20                  25                  30          
Cys Thr Phe Pro Leu Ala Glu Lys Val Lys Thr Phe Leu Ala Asp Leu
        35                  40                  45              
Pro Ala Leu Trp Leu Leu Pro Val
    50                  55      


<210> 2739
<211> 116
<212> PRT
<213> Homo sapiens

<400> 2739
Met Ala Ser Thr Val Val Ala Val Gly Leu Thr Ile Ala Ala Ala Gly
 1               5                  10                  15      
Phe Ala Gly Arg Tyr Val Leu Gln Ala Met Lys His Met Glu Pro Gln
            20                  25                  30          
Val Lys Gln Val Phe Gln Ser Leu Pro Lys Ser Ala Phe Ser Gly Gly
        35                  40                  45              
Tyr Tyr Arg Gly Gly Phe Glu Pro Lys Met Thr Lys Arg Glu Ala Ala
    50                  55                  60                  
Leu Ile Leu Gly Val Ser Pro Thr Ala Asn Lys Gly Lys Ile Arg Asp
65                  70                  75                  80  
Ala His Arg Arg Ile Met Leu Leu Asn His Pro Asp Lys Gly Gly Ser
                85                  90                  95      
Pro Tyr Ile Ala Ala Lys Ile Asn Glu Ala Lys Asp Leu Leu Glu Gly
            100                 105                 110         
Gln Ala Lys Lys
        115     


<210> 2740
<211> 365
<212> PRT
<213> Homo sapiens

<400> 2740
Met Glu Glu Asp Asn Trp Arg Trp His Phe Tyr Asp Thr Val Lys Gly
 1               5                  10                  15      
Ser Asp Trp Leu Gly Asp Gln Asp Ala Ile His Tyr Val Thr Glu Gln
            20                  25                  30          
Ala Pro Thr Ala Met Val Ala Val Glu Asn Tyr Gly Met Pro Phe Ser
        35                  40                  45              
Arg Thr Glu Asp Gly Lys Ile Tyr Gln Arg Ala Phe Gly Gly His Ser
    50                  55                  60                  
Leu Lys Phe Gly Lys Gly Gly Gln Ala His Gly Cys Cys Cys Val Ala
65                  70                  75                  80  
Asp Arg Thr Gly His Ser Ile Leu His Thr Leu Tyr Gly Arg Ser Leu
                85                  90                  95      
Arg Tyr Asp Thr Ser Cys Phe Val Glu Tyr Phe Ala Leu Asp Leu Leu
            100                 105                 110         
Met Glu Asn Gly Glu Cys Arg Gly Val Phe Ala Leu Cys Ile Gln Asp
        115                 120                 125             
Gly Ser Ile His Arg Ile Arg Ala Lys Asn Thr Ile Val Ala Thr Gly
    130                 135                 140                 
Gly Tyr Trp Arg Asn Tyr Leu Ser Cys Thr Ser Ala His Thr Ser Thr
145                 150                 155                 160 
Ser Asp Gly Thr Ala Met Ile Thr Arg Ala Gly Leu Pro Cys Gln Asp
                165                 170                 175     
Leu Glu Phe Val Gln Phe His Pro Thr Gly Thr Tyr Gly Ala Gly Cys
            180                 185                 190         
Leu Ile Thr Glu Gly Cys Arg Gly Glu Gly Gly Ile Leu Ile Asn Ser
        195                 200                 205             
Gln Gly Glu Arg Phe Met Glu Arg Tyr Ala Pro Ile Ala Lys Asp Leu
    210                 215                 220                 
Ala Ser Arg Asp Val Val Ser Arg Trp Met Thr Leu Glu Ile Arg Glu
225                 230                 235                 240 
Gly Arg Gly Cys Gly Pro Glu Lys Asp His Val Tyr Leu Gln Leu His
                245                 250                 255     
His Leu Pro Pro Glu Gln Leu Ala Met Pro Leu Pro Gly Ile Ser Glu
            260                 265                 270         
Thr Ala Met Ile Phe Ala Gly Val Asp Val Thr Lys Glu Pro Ile Pro
        275                 280                 285             
Val Leu Pro Thr Val His Tyr Asn Met Asp Gly Ile Pro Thr Ser Tyr
    290                 295                 300                 
Glu Gly Gln Val Leu Arg His Gly Asn Gly Gln Asp Gln Ile Val Pro
305                 310                 315                 320 
Gly Leu Tyr Ala Cys Gly Glu Ala Ala Cys Ala Ser Ala His Gly Val
                325                 330                 335     
Asn Arg Leu Gly Ala Asn Ser Leu Leu Asp Leu Val Val Trp Ser Gly
            340                 345                 350         
Met Cys Pro Glu His Arg Arg Val Val Gln Ala Trp Arg
        355                 360                 365 


<210> 2741
<211> 102
<212> PRT
<213> Homo sapiens

<400> 2741
Met Ser Val Asp Thr Gly Gly Ala Phe Pro Phe Ser Asn Ala Glu Gly
 1               5                  10                  15      
Trp Pro Leu Met Gly Gln Met Lys His Cys Gln Phe Glu Val Ala Val
            20                  25                  30          
Gln Gly Lys Leu Arg Cys Glu Ser His Trp Tyr Lys Thr Leu Leu Ser
        35                  40                  45              
Gly Leu Gln Ala Phe Trp Val Phe Ser Asp Glu Asp Lys Leu Tyr Ser
    50                  55                  60                  
Glu Asn Trp Ala Ala Leu Leu Val Phe Asp Pro Arg Gly Thr Phe Val
65                  70                  75                  80  
Gln Gln Ser Glu Ile Tyr Asn Thr Ile Gln Gly Ala Ala Ala Ser Thr
                85                  90                  95      
His Gln Cys Gln Ala Ala
            100         


<210> 2742
<211> 209
<212> PRT
<213> Homo sapiens

<400> 2742
Met Val Ala Leu Ser Pro Ala His Pro Arg Ser Pro Ala Leu Cys Ser
 1               5                  10                  15      
Cys Ala Leu Leu Ala Thr Ser Phe Pro Leu Tyr Pro Ala Leu Thr Lys
            20                  25                  30          
Tyr Ala Cys Val Met Cys Ser Asp Pro Ser Val Pro Leu Pro Ala Pro
        35                  40                  45              
Arg Ser Gln Arg Ser Arg Ala Trp Lys Ser Pro Lys Phe Thr Ala Val
    50                  55                  60                  
Ala Pro Ser Phe Tyr Met Arg Met His His Ser Asn Asp Leu Ser Arg
65                  70                  75                  80  
Asn Val Leu Ile Asp Asn Val Leu Leu His Ala Arg Glu Glu Pro Asp
                85                  90                  95      
Pro Cys Ser Gly Thr Ser Cys Val Ala Gly Thr Ser Val Thr Arg Asp
            100                 105                 110         
Thr Pro Ala Gly Ile Asn Arg Pro Asp Leu Asp Thr Cys Ile Ala Ala
        115                 120                 125             
Ala Arg Leu Ala Ser Val Ser Ser Ala Lys Glu Phe Leu Val Val Leu
    130                 135                 140                 
Thr Glu Arg Gly Gln Val Leu Leu Asp Ala Glu Ala Arg Lys Gln Val
145                 150                 155                 160 
Ala Gly Asn Glu Asn Gly Pro Lys Pro Arg Ala Asn Ile Glu Leu Gln
                165                 170                 175     
Gln Gln Gly Cys Trp Arg Gly Arg Ser Leu Pro Gly Arg Gln Lys Leu
            180                 185                 190         
Phe Ser Lys Glu Asn Leu Gly Thr Val Ala Pro Ser Pro Leu Gly Thr
        195                 200                 205             
Gly
    


<210> 2743
<211> 361
<212> PRT
<213> Homo sapiens

<400> 2743
Met Asp Asp Phe Arg Thr Ser Ala Pro Glu Pro Arg Gly Pro Pro Asn
 1               5                  10                  15      
Pro Asn Val Glu Tyr Ile Pro Phe Asp Glu Met Lys Glu Arg Ile Leu
            20                  25                  30          
Lys Ile Val Thr Gly Phe Asn Gly Ile Pro Phe Thr Ile Gln Arg Leu
        35                  40                  45              
Cys Glu Leu Leu Thr Asp Pro Arg Arg Asn Tyr Thr Gly Thr Asp Lys
    50                  55                  60                  
Phe Leu Arg Gly Val Glu Lys Asn Val Met Val Val Ser Cys Val Tyr
65                  70                  75                  80  
Pro Ser Ser Glu Lys Asn Asn Ser Asn Ser Leu Asn Arg Met Asn Gly
                85                  90                  95      
Val Met Phe Pro Gly Asn Ser Pro Ser Tyr Thr Glu Arg Ser Asn Ile
            100                 105                 110         
Asn Gly Pro Gly Thr Pro Arg Pro Leu Asn Arg Pro Lys Val Ser Leu
        115                 120                 125             
Ser Ala Pro Met Thr Thr Asn Gly Leu Pro Glu Ser Thr Asp Ser Lys
    130                 135                 140                 
Glu Ala Asn Leu Gln Gln Asn Glu Glu Lys Asn His Ser Asp Ser Ser
145                 150                 155                 160 
Thr Ser Glu Ser Glu Val Ser Ser Val Ser Pro Leu Lys Asn Lys His
                165                 170                 175     
Pro Asp Glu Asp Ala Val Glu Ala Glu Gly His Glu Val Lys Arg Leu
            180                 185                 190         
Arg Phe Asp Lys Glu Gly Glu Val Arg Glu Thr Ala Ser Gln Thr Thr
        195                 200                 205             
Ser Ser Glu Ile Ser Ser Val Met Val Gly Glu Thr Glu Ala Ser Ser
    210                 215                 220                 
Ser Ser Gln Asp Lys Asp Lys Asp Ser Arg Cys Thr Arg Gln His Cys
225                 230                 235                 240 
Thr Glu Glu Asp Glu Glu Glu Asp Glu Glu Glu Glu Glu Glu Ser Phe
                245                 250                 255     
Met Thr Ser Arg Glu Met Ile Pro Glu Arg Lys Asn Gln Glu Lys Glu
            260                 265                 270         
Ser Asp Asp Ala Leu Thr Val Asn Glu Glu Thr Ser Glu Glu Asn Asn
        275                 280                 285             
Gln Met Glu Glu Ser Asp Val Ser Gln Ala Glu Lys Asp Leu Leu His
    290                 295                 300                 
Ser Glu Gly Ser Glu Asn Glu Gly Pro Val Ser Ser Ser Ser Ser Asp
305                 310                 315                 320 
Cys Arg Glu Thr Glu Glu Leu Val Gly Ser Asn Ser Ser Lys Thr Gly
                325                 330                 335     
Glu Ile Leu Ser Glu Ser Ser Met Glu Asn Asp Asp Glu Ala Thr Glu
            340                 345                 350         
Val Thr Asp Glu Pro Met Glu Gln Asp
        355                 360     


<210> 2744
<211> 203
<212> PRT
<213> Homo sapiens

<400> 2744
Met Ser Trp Asp Cys Thr Met Phe Gly Trp Asn Leu Asp Gly Asn Ala
 1               5                  10                  15      
Arg Gly Ser Val Lys Leu Gly Asp Thr Gly Arg Tyr Thr Cys Ile Ala
            20                  25                  30          
Ser Thr Pro Ser Gly Glu Ala Thr Trp Ser Ala Tyr Ile Glu Val Gln
        35                  40                  45              
Glu Phe Gly Val Pro Val Gln Pro Pro Arg Pro Thr Asp Pro Asn Leu
    50                  55                  60                  
Ile Pro Ser Ala Pro Ser Lys Pro Glu Val Thr Asp Val Ser Arg Asn
65                  70                  75                  80  
Thr Val Thr Leu Ser Trp Gln Pro Asn Leu Asn Ser Gly Ala Thr Pro
                85                  90                  95      
Thr Ser Tyr Ile Ile Glu Ala Phe Ser His Ala Ser Gly Ser Ser Trp
            100                 105                 110         
Gln Thr Val Ala Glu Asn Val Lys Thr Glu Thr Ser Ala Ile Lys Gly
        115                 120                 125             
Leu Lys Pro Asn Ala Ile Tyr Leu Phe Leu Val Arg Ala Ala Asn Ala
    130                 135                 140                 
Tyr Gly Ile Ser Asp Pro Ser Gln Ile Ser Asp Pro Val Lys Thr Gln
145                 150                 155                 160 
Asp Tyr Arg Ala Asn Asp Thr Val Pro Pro Thr Ile Pro Tyr Asn Gln
                165                 170                 175     
Ser Tyr Asp Gln Asn Thr Gly Gly Ser Tyr Asn Ser Ser Asp Arg Gly
            180                 185                 190         
Ser Ser Thr Ser Ala Val Cys Gln Leu Phe Ser
        195                 200             


<210> 2745
<211> 284
<212> PRT
<213> Homo sapiens

<400> 2745
Met Asn Asp Ser Glu Arg Pro Val Ser Ser Glu Asp Phe Ser Arg Ala
 1               5                  10                  15      
Val Leu Ser Tyr Gln Pro Pro Ser Pro Ser Asn Ala Leu Lys Gln Ala
            20                  25                  30          
Lys Leu Leu Gln Ala Asn Ile Pro Ser Ala Asn Ile Pro Ser Ala Thr
        35                  40                  45              
Ser Ser Leu Ser Pro Val Leu Thr Pro Phe Ala Leu Lys Pro Asp Gly
    50                  55                  60                  
Thr Arg Leu Phe Pro Asn Val Met Ser Pro Leu Ala Ser Asp Leu Leu
65                  70                  75                  80  
Pro Gln Met Pro Gly Ser Met Leu Phe Gln Ser Pro Phe Ser Ile Val
                85                  90                  95      
Ala Leu Glu Pro Ser Lys Lys Gly Lys Arg Lys Pro Pro Asn Ile Ser
            100                 105                 110         
Thr Val Asp Leu Lys Pro Lys Asp Glu Ala Val Leu Tyr Lys His Lys
        115                 120                 125             
Met Thr Ala Leu Leu Ala Ala Gln Pro Arg Gln Gln Ala Lys Gln His
    130                 135                 140                 
Gly Cys Met Trp Cys Gly Lys Asn Phe Ser Ser Thr Gly Ala Leu Arg
145                 150                 155                 160 
Ile His Gly Trp Thr His Thr Gly Glu Lys Ser Phe Pro Ser Met Pro
                165                 170                 175     
Ser Gly Ser Leu Ala Met Lys Thr Ser Glu Ile Ser Val Val Arg Ser
            180                 185                 190         
Gly Gly Val Pro Asn Leu Leu Leu Ser Leu Gly Ala Ser Ser Ile Val
        195                 200                 205             
Asn Asn Thr Thr Val Phe Lys Met Asp Gly Ser Gln Ser Gly Ile Ser
    210                 215                 220                 
Ala Asp Val Glu Lys Pro Gly Leu Trp Ser Thr Val Gly Glu Asp Phe
225                 230                 235                 240 
Leu Trp Lys Pro Leu Ala Ser Leu Leu Pro Lys Met Gln Ala Arg Gly
                245                 250                 255     
Gly Val Gln Leu Arg Glu Glu Cys Leu Asp Phe Trp Lys Tyr Gly Leu
            260                 265                 270         
Leu Val Ser Phe Trp Ile Ile Asn His Glu Gly Tyr
        275                 280                 


<210> 2746
<211> 208
<212> PRT
<213> Homo sapiens

<400> 2746
Met Ser Leu Gly Gly Ala Ser Glu Arg Ser Val Pro Ala Thr Lys Ile
 1               5                  10                  15      
Glu Ile Thr Val Ser Cys Arg Asn Leu Leu Asp Leu Asp Thr Phe Ser
            20                  25                  30          
Lys Ser Asp Pro Met Val Val Leu Tyr Thr Gln Ser Arg Ala Ser Gln
        35                  40                  45              
Glu Trp Arg Glu Phe Gly Arg Thr Glu Val Ile Asp Asn Thr Leu Asn
    50                  55                  60                  
Pro Asp Phe Val Arg Lys Phe Val Leu Asp Tyr Phe Phe Glu Glu Lys
65                  70                  75                  80  
Gln Asn Leu Arg Phe Asp Val Ser Thr Ser Gly Pro Thr Pro Ser Thr
                85                  90                  95      
Gln Pro Cys Pro Gln Gln Pro Leu Thr Trp Pro Arg Pro Arg Leu Asp
            100                 105                 110         
Arg Leu Thr Thr Gln Pro Thr Leu Thr Pro Pro Gln Lys Glu Thr Lys
        115                 120                 125             
Ala Glu Phe Gly Ser Thr Ala Ala His Pro Ser Thr Gln Asn Phe His
    130                 135                 140                 
Gln Asp Ser Val Pro Asp Pro Phe Pro Pro Ser Pro Pro Pro Ser Pro
145                 150                 155                 160 
Thr Pro His Arg Phe His Ser Phe Pro Arg Tyr Asn Val Asp Ser Lys
                165                 170                 175     
Thr Asn Ile Ser Lys Pro Asp Phe Leu Gly Gln Ala Phe Leu Ala Leu
            180                 185                 190         
Gly Glu Val Ile Gly Gly Gln Gly Ser Arg Val Glu Arg Thr Leu Thr
        195                 200                 205             


<210> 2747
<211> 1329
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123,
124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135,
136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147,
148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158
<223> Xaa = Any Amino Acid

<221> VARIANT        
<222> 159, 160, 161, 162, 163, 164, 229, 230, 231, 232, 233, 234,
235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246,
247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258,
259, 260, 261, 262, 263, 264, 265, 266, 267, 268, 269
<223> Xaa = Any Amino Acid

<221> VARIANT        
<222> 270, 271, 272, 273, 274, 275, 276, 277, 278, 279, 280, 281,
282, 283, 284, 285, 286, 287, 288, 289, 290, 291, 292, 293,
294, 295, 296, 297, 298, 299, 300, 301, 302, 303, 304, 305,
306, 307, 308, 309, 310, 311, 312, 313, 314, 315, 316
<223> Xaa = Any Amino Acid

<221> VARIANT        
<222> 317, 318, 319, 320, 321, 322, 323, 324, 325, 326, 327, 843,
844, 845, 846, 847, 848, 849, 850, 851, 852, 853, 854, 855,
856, 857, 858, 859, 860, 861, 862, 863, 864, 865, 866, 867,
868, 869, 870, 871, 872, 873, 874, 875, 876, 877, 878
<223> Xaa = Any Amino Acid

<221> VARIANT        
<222> 879, 880, 881, 882, 883, 884, 885, 886, 887
<223> Xaa = Any Amino Acid

<400> 2747
Met Lys Asn Thr Gly Lys Thr Val Ala Ile Leu Leu Lys Asp Asp Tyr
 1               5                  10                  15      
Phe Val Ser Gly Ala Gly Leu Pro Gly Arg Phe Lys Ala Glu Lys Val
            20                  25                  30          
Glu Phe His Trp Gly His Ser Asn Gly Ser Ala Gly Ser Glu His Ser
        35                  40                  45              
Ile Asn Gly Arg Arg Phe Pro Val Glu Met Gln Ile Phe Phe Tyr Asn
    50                  55                  60                  
Pro Asp Asp Phe Asp Ser Phe Gln Thr Ala Ile Ser Glu Asn Arg Ile
65                  70                  75                  80  
Ile Gly Ala Met Ala Ile Phe Phe Gln Val Ser Pro Arg Ala Asn Ser
                85                  90                  95      
Ala Leu Asp Pro Ile Ile His Gly Leu Lys Gly Val Val His His Xaa
            100                 105                 110         
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
        115                 120                 125             
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    130                 135                 140                 
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
145                 150                 155                 160 
Xaa Xaa Xaa Xaa Leu Glu Ala Phe Tyr Ser Ile Phe Thr Thr Glu Gln
                165                 170                 175     
Gln Asp His Val Lys Ser Val Glu Tyr Leu Arg Asn Asn Phe Arg Pro
            180                 185                 190         
Gln Gln Arg Leu His Asp Arg Val Val Ser Lys Ser Ala Val Arg Asp
        195                 200                 205             
Ser Trp Asn His Asp Met Thr Asp Phe Leu Glu Asn Pro Leu Gly Thr
    210                 215                 220                 
Glu Ala Ser Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
225                 230                 235                 240 
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
                245                 250                 255     
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            260                 265                 270         
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
        275                 280                 285             
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    290                 295                 300                 
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
305                 310                 315                 320 
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asn Thr Thr Arg Ile Phe Gln Gly Thr
                325                 330                 335     
Arg Ile Val Lys Thr Gly Val Pro Thr Ala Ser Pro Ala Ser Ser Ala
            340                 345                 350         
Asp Met Ala Pro Ile Ser Ser Gly Ser Ser Thr Trp Thr Ser Ser Gly
        355                 360                 365             
Ile Pro Phe Ser Phe Val Ser Met Ala Thr Gly Met Gly Pro Ser Ser
    370                 375                 380                 
Ser Gly Ser Gln Ala Thr Val Ala Ser Val Val Thr Ser Thr Leu Leu
385                 390                 395                 400 
Ala Gly Leu Gly Phe Gly Gly Gly Gly Ile Ser Ser Phe Pro Ser Thr
                405                 410                 415     
Val Trp Pro Thr Arg Leu Pro Thr Ala Ala Ser Ala Ser Lys Gln Ala
            420                 425                 430         
Ala Arg Pro Val Leu Ala Thr Thr Glu Ala Leu Ala Ser Pro Gly Pro
        435                 440                 445             
Asp Gly Asp Ser Ser Pro Thr Lys Asp Gly Glu Gly Thr Glu Glu Gly
    450                 455                 460                 
Glu Lys Asp Glu Lys Ser Glu Ser Glu Asp Gly Glu Arg Glu His Glu
465                 470                 475                 480 
Glu Asp Gly Glu Lys Asp Ser Glu Lys Lys Glu Lys Ser Gly Val Thr
                485                 490                 495     
His Ala Ala Glu Glu Arg Asn Gln Thr Glu Pro Ser Pro Thr Pro Ser
            500                 505                 510         
Ser Pro Asn Arg Thr Ala Glu Gly Gly His Gln Thr Ile Pro Gly His
        515                 520                 525             
Glu Gln Asp His Thr Ala Val Pro Thr Asp Gln Thr Gly Gly Arg Arg
    530                 535                 540                 
Asp Ala Gly Pro Gly Leu Asp Pro Asp Met Val Thr Ser Thr Gln Val
545                 550                 555                 560 
Pro Pro Thr Ala Thr Glu Glu Gln Tyr Ala Gly Ser Asp Pro Lys Arg
                565                 570                 575     
Pro Glu Met Pro Ser Lys Lys Pro Met Ser Arg Gly Asp Arg Phe Ser
            580                 585                 590         
Glu Asp Ser Arg Phe Ile Thr Val Asn Pro Ala Glu Lys Asn Thr Ser
        595                 600                 605             
Gly Met Ile Ser Arg Pro Ala Pro Gly Arg Met Glu Trp Ile Ile Pro
    610                 615                 620                 
Leu Ile Val Val Ser Ala Leu Thr Phe Val Cys Leu Ile Leu Leu Ile
625                 630                 635                 640 
Ala Val Leu Val Tyr Trp Arg Gly Cys Asn Lys Ile Lys Ser Lys Gly
                645                 650                 655     
Phe Pro Arg Arg Phe Arg Glu Val Pro Ser Ser Gly Glu Arg Gly Glu
            660                 665                 670         
Lys Gly Ser Arg Lys Cys Phe Gln Thr Ala His Phe Tyr Val Glu Asp
        675                 680                 685             
Ser Ser Ser Pro Arg Val Val Pro Asn Glu Ser Ile Pro Ile Ile Pro
    690                 695                 700                 
Ile Pro Asp Asp Met Glu Ala Ile Pro Val Lys Gln Phe Val Lys His
705                 710                 715                 720 
Ile Gly Glu Leu Tyr Ser Asn Asn Gln His Gly Phe Ser Glu Asp Phe
                725                 730                 735     
Glu Glu Val Gln Arg Cys Thr Ala Asp Met Asn Ile Thr Ala Glu His
            740                 745                 750         
Ser Asn His Pro Glu Asn Lys His Lys Asn Arg Tyr Ile Asn Ile Leu
        755                 760                 765             
Ala Tyr Asp His Ser Arg Val Lys Leu Arg Pro Leu Pro Gly Lys Asp
    770                 775                 780                 
Ser Lys His Ser Asp Tyr Ile Asn Ala Asn Tyr Val Asp Gly Tyr Asn
785                 790                 795                 800 
Lys Ala Lys Ala Tyr Ile Ala Thr Gln Gly Pro Leu Lys Ser Thr Phe
                805                 810                 815     
Glu Asp Phe Trp Arg Met Ile Trp Glu Gln Asn Thr Gly Ile Ile Val
            820                 825                 830         
Met Ile Thr Asn Leu Val Glu Lys Gly Arg Xaa Xaa Xaa Xaa Xaa Xaa
        835                 840                 845             
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    850                 855                 860                 
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
865                 870                 875                 880 
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Gln Lys Gly Asn Pro Lys Gly Arg
                885                 890                 895     
Gln Asn Glu Arg Val Val Ile Gln Tyr His Tyr Thr Gln Trp Pro Asp
            900                 905                 910         
Met Gly Val Pro Glu Tyr Ala Leu Pro Val Leu Thr Phe Val Arg Arg
        915                 920                 925             
Ser Ser Ala Ala Arg Met Pro Glu Thr Gly Pro Val Leu Val His Cys
    930                 935                 940                 
Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Val Ile Asp Ser Met
945                 950                 955                 960 
Leu Gln Gln Ile Lys Asp Lys Ser Thr Val Asn Val Leu Gly Phe Leu
                965                 970                 975     
Lys His Ile Arg Thr Gln Arg Asn Tyr Leu Val Gln Thr Glu Glu Gln
            980                 985                 990         
Tyr Ile Phe Ile His Asp Ala Leu Leu Glu Ala Ile Leu Gly Lys Glu
        995                 1000                1005            
Thr Glu Val Ser Ser Asn Gln Leu His Ser Tyr Val Asn Ser Ile Leu
    1010                1015                1020                
Ile Pro Gly Val Gly Gly Lys Thr Arg Leu Glu Lys Gln Phe Lys Leu
1025                1030                1035                1040
Val Thr Gln Cys Asn Ala Lys Tyr Val Glu Cys Phe Ser Ala Gln Lys
                1045                1050                1055    
Glu Cys Asn Lys Glu Lys Asn Arg Asn Ser Ser Val Val Pro Ser Glu
            1060                1065                1070        
Arg Ala Arg Val Gly Leu Ala Pro Leu Pro Gly Met Lys Gly Thr Asp
        1075                1080                1085            
Tyr Ile Asn Ala Ser Tyr Ile Met Gly Tyr Tyr Arg Ser Asn Glu Phe
    1090                1095                1100                
Ile Ile Thr Gln His Pro Leu Pro His Thr Thr Lys Asp Phe Trp Arg
1105                1110                1115                1120
Met Ile Trp Asp His Asn Ala Gln Ile Ile Val Met Leu Pro Asp Asn
                1125                1130                1135    
Gln Ser Leu Ala Glu Asp Glu Phe Val Tyr Trp Pro Ser Arg Glu Glu
            1140                1145                1150        
Ser Met Asn Cys Glu Ala Phe Thr Val Thr Leu Ile Ser Lys Asp Arg
        1155                1160                1165            
Leu Cys Leu Ser Asn Glu Glu Gln Ile Ile Ile His Asp Phe Ile Leu
    1170                1175                1180                
Glu Ala Thr Gln Asp Asp Tyr Val Leu Glu Val Arg His Phe Gln Cys
1185                1190                1195                1200
Pro Lys Trp Pro Asn Pro Asp Ala Pro Ile Ser Ser Thr Phe Glu Leu
                1205                1210                1215    
Ile Asn Val Ile Lys Glu Glu Ala Leu Thr Arg Asp Gly Pro Thr Ile
            1220                1225                1230        
Val His Asp Glu Tyr Gly Ala Val Ser Ala Gly Met Leu Cys Ala Leu
        1235                1240                1245            
Thr Thr Leu Ser Gln Gln Leu Glu Asn Glu Asn Ala Val Asp Val Phe
    1250                1255                1260                
Gln Val Ala Lys Met Ile Asn Leu Met Arg Pro Gly Val Phe Thr Asp
1265                1270                1275                1280
Ile Glu Gln Tyr Gln Phe Ile Tyr Lys Ala Met Leu Ser Leu Val Ser
                1285                1290                1295    
Thr Lys Glu Asn Gly Asn Gly Pro Met Thr Val Asp Lys Asn Gly Ala
            1300                1305                1310        
Val Leu Ile Ala Asp Glu Ser Asp Pro Ala Glu Ser Met Glu Ser Leu
        1315                1320                1325            
Val
    


<210> 2748
<211> 144
<212> PRT
<213> Homo sapiens

<400> 2748
Met Cys Lys Lys Val Cys Leu Ala Ser Ser Ser Cys Leu Met Ala Ala
 1               5                  10                  15      
Gly Gly Ser Gly Thr His Arg Lys Ser Gly Thr Glu Arg Ser Ser Ala
            20                  25                  30          
Asp Lys Lys Trp Gln Arg Leu Ser Lys Gly Lys Ala Ala Ala Ala Thr
        35                  40                  45              
Gly Pro Thr Cys Ser Ala Leu Gln Leu His Arg Arg Pro Thr Ala Lys
    50                  55                  60                  
Phe Leu Val Met Asp Gln Phe Glu Asn Gln Lys Gln Gln Gln Ile Phe
65                  70                  75                  80  
Lys His Tyr Ala Asn Lys Gly Thr Ser Ala Asp Arg Asn Glu Val Glu
                85                  90                  95      
Gln Ser Asn Val Ile Glu Gly Cys Ala Asn Ser Ser Leu Asn Arg Gln
            100                 105                 110         
Glu Lys Gln Ile Glu Arg Arg Leu Glu Ile Thr Pro Asn Asn Val Gln
        115                 120                 125             
Val Leu Leu Lys Leu Ala Leu Gly Leu Asp Ile Met Gln Ala Arg Arg
    130                 135                 140                 


<210> 2749
<211> 556
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 529
<223> Xaa = Any Amino Acid

<400> 2749
Met Leu Ala Asp Lys Ile Gly Ile Phe Pro Ile Ser Tyr Val Glu Phe
 1               5                  10                  15      
Asn Ser Ala Ala Lys Gln Leu Ile Glu Trp Asp Lys Pro Pro Val Pro
            20                  25                  30          
Gly Val Asp Ala Gly Glu Cys Ser Ser Ala Ala Ala Gln Ser Ser Thr
        35                  40                  45              
Ala Pro Lys His Ser Asp Thr Lys Lys Asn Thr Lys Lys Arg His Ser
    50                  55                  60                  
Phe Thr Ser Leu Thr Met Ala Asn Lys Ser Ser Gln Ala Ser Gln Asn
65                  70                  75                  80  
Arg His Ser Met Glu Ile Ser Pro Pro Val Leu Ile Ser Ser Ser Asn
                85                  90                  95      
Pro Thr Ala Ala Ala Arg Ile Ser Glu Leu Ser Gly Leu Ser Cys Ser
            100                 105                 110         
Ala Pro Ser Gln Val His Ile Ser Thr Thr Gly Leu Ile Val Thr Pro
        115                 120                 125             
Pro Pro Ser Ser Pro Val Thr Thr Gly Pro Ser Phe Thr Phe Pro Ser
    130                 135                 140                 
Asp Val Pro Tyr Gln Ala Ala Leu Gly Thr Leu Asn Pro Pro Leu Pro
145                 150                 155                 160 
Pro Pro Pro Leu Leu Ala Ala Thr Val Leu Ala Ser Thr Pro Pro Gly
                165                 170                 175     
Ala Thr Ala Ala Ala Ala Ala Ala Gly Met Gly Pro Arg Pro Met Ala
            180                 185                 190         
Gly Ser Thr Asp Gln Ile Ala His Leu Arg Pro Gln Thr Arg Pro Ser
        195                 200                 205             
Val Tyr Val Ala Ile Tyr Pro Tyr Thr Pro Arg Lys Glu Asp Glu Leu
    210                 215                 220                 
Glu Leu Arg Lys Gly Glu Met Phe Leu Val Phe Glu Arg Cys Gln Asp
225                 230                 235                 240 
Gly Trp Phe Lys Gly Thr Ser Met His Thr Ser Lys Ile Gly Val Phe
                245                 250                 255     
Pro Gly Asn Tyr Val Ala Pro Val Thr Arg Ala Val Thr Asn Ala Ser
            260                 265                 270         
Gln Ala Lys Val Pro Met Ser Thr Ala Gly Gln Thr Ser Arg Gly Val
        275                 280                 285             
Thr Met Val Ser Pro Ser Thr Ala Gly Gly Pro Ala Gln Lys Leu Gln
    290                 295                 300                 
Gly Asn Gly Val Ala Gly Ser Pro Ser Val Val Pro Ala Ala Val Val
305                 310                 315                 320 
Ser Ala Ala His Ile Gln Thr Ser Pro Gln Ala Lys Val Leu Leu His
                325                 330                 335     
Met Thr Gly Gln Met Thr Val Asn Gln Ala Arg Asn Ala Val Arg Thr
            340                 345                 350         
Val Ala Ala His Asn Gln Glu Arg Pro Thr Ala Ala Val Thr Pro Ile
        355                 360                 365             
Gln Val Gln Asn Ala Ala Gly Leu Ser Pro Ala Ser Val Gly Leu Ser
    370                 375                 380                 
His His Ser Leu Ala Ser Pro Gln Pro Ala Pro Leu Met Pro Gly Ser
385                 390                 395                 400 
Ala Thr His Thr Ala Ala Ile Ser Ile Ser Arg Ala Ser Ala Pro Leu
                405                 410                 415     
Ala Cys Ala Ala Ala Ala Pro Leu Thr Ser Pro Ser Ile Thr Ser Ala
            420                 425                 430         
Ser Leu Glu Ala Glu Pro Ser Gly Arg Ile Val Thr Val Leu Pro Gly
        435                 440                 445             
Leu Pro Thr Ser Pro Asp Ser Ala Ser Ser Ala Cys Gly Asn Ser Ser
    450                 455                 460                 
Ala Thr Lys Pro Asp Lys Asp Ser Lys Lys Glu Lys Lys Gly Leu Leu
465                 470                 475                 480 
Lys Leu Leu Ser Gly Ala Ser Thr Lys Arg Lys Pro Arg Val Ser Pro
                485                 490                 495     
Pro Ala Ser Pro Thr Leu Glu Val Glu Leu Gly Ser Ala Glu Leu Pro
            500                 505                 510         
Leu Gln Gly Ala Val Gly Pro Glu Leu Pro Pro Gly Gly Gly His Gly
        515                 520                 525             
Xaa Gly Arg Leu Leu Pro Cys Gly Arg Gly Arg Thr Gly His Asp Cys
    530                 535                 540                 
Ser Gly Arg Ser Ser Pro Gly Pro Gly Cys Phe Ser
545                 550                 555     


<210> 2750
<211> 495
<212> PRT
<213> Homo sapiens

<400> 2750
Met Ala Phe Ala Ala Ser Leu Ala Glu Leu Gln Ala Glu Ala Ser Cys
 1               5                  10                  15      
Pro Ile Cys Leu Asp Tyr Met Lys Asp His Ser Leu Trp Ala Gln Leu
            20                  25                  30          
Leu Ser Leu Leu His Pro Gln Cys Trp Glu Asp Leu Gln Asp Val Leu
        35                  40                  45              
Pro Cys Pro Val Cys Leu Arg His Cys Pro Asp Glu Asn Leu Arg Ser
    50                  55                  60                  
Asn Thr Gln Leu Cys His Met Thr Asp Met Val Gln Gln Leu Leu Thr
65                  70                  75                  80  
Met Arg Ser Lys Arg Lys Trp Gln Glu Glu Glu Pro Leu Cys Gly Lys
                85                  90                  95      
His Ser Gln Arg Leu Ala Leu Phe Cys Glu Lys Gly Leu Glu Leu Leu
            100                 105                 110         
Cys Pro Gln Cys Arg Val Ser Ser Asp His Gln Tyr His Arg Leu Met
        115                 120                 125             
Pro Ile Glu Gln Ala Ala Ala Arg Asn Arg Arg Lys Leu Glu Ser Tyr
    130                 135                 140                 
Ile Lys Pro Leu Lys Lys Glu Thr Glu His Ala Lys Met Arg Cys Glu
145                 150                 155                 160 
Val Pro Ile Leu Ser Ser Leu Asn Val Lys Arg Lys Met Ala Thr Trp
                165                 170                 175     
Arg Lys Glu Leu Gln Ser Glu Phe Lys Glu Ile Lys Tyr Phe Leu Val
            180                 185                 190         
Lys Lys Gln Ala Ala Ile His Ala Arg Leu Leu Thr Glu Glu Lys Asp
        195                 200                 205             
Asp Lys Glu Lys Leu Thr Glu Asn Arg Arg Gln Ile Ser Asp His Leu
    210                 215                 220                 
Ser Thr Leu Gln Asn Phe Leu Asn Glu Val Thr Glu Lys Cys Phe Arg
225                 230                 235                 240 
Ala Asp Leu Asp Val Leu Thr Gly Val Glu Asn Thr Tyr Asn Thr Tyr
                245                 250                 255     
Asp Asn Leu Lys Thr Pro Ala Val Phe Ser Tyr Lys Leu Lys Lys Glu
            260                 265                 270         
Ser Leu Ser Phe Pro Pro His Tyr Phe Gly Leu Gln Arg Ile Ile Ser
        275                 280                 285             
Thr Phe Gln Glu Asp Leu Met Leu Asp Pro Glu Thr Ala His Pro Ser
    290                 295                 300                 
Leu Ile Ile Ser Arg Asp Arg Lys Asn Val Ile Phe Arg Met Arg Lys
305                 310                 315                 320 
Pro His Phe Thr Asp Asn Pro Pro Ser Phe Ser Phe Tyr Pro Ala Val
                325                 330                 335     
Trp Ser Cys Glu Gly Phe Asp Ala Gly Arg His Phe Trp Gln Val Glu
            340                 345                 350         
Val Arg Gly Thr Gly Ala Cys Ser Leu Val Gln Pro Leu Pro Leu Thr
        355                 360                 365             
Pro Gly Gln Pro Leu Leu Pro Pro Gly Ser Gln Gly His Glu Gln Ser
    370                 375                 380                 
Gln Pro Leu Leu Cys Leu Ser Arg Arg Ser Met Pro Gly Val Leu Arg
385                 390                 395                 400 
Gln Trp Thr Gly Arg Glu Gln Gly Glu Gly Val Asp Ser Glu Asp Gln
                405                 410                 415     
Glu Val Pro Arg Gly Ser Ser Ala Gly Ala Pro His Pro Ser Asp Glu
            420                 425                 430         
Ala Asp Ser Gly Glu Asp Thr Lys Met Gly Lys Asn Lys Phe Val His
        435                 440                 445             
Ser Arg Ser Phe Tyr Phe Cys Arg Ile Pro Tyr Val Leu Lys Lys Leu
    450                 455                 460                 
Ser Asp Gln Asp Glu Cys Ile Met Ala His Glu Gly Arg Ile Lys Cys
465                 470                 475                 480 
Tyr Gly Asp Glu Lys Ala Met Ile Thr Gly Lys Phe Pro Asp Pro
                485                 490                 495 


<210> 2751
<211> 478
<212> PRT
<213> Homo sapiens

<400> 2751
Met Ala Gly Gly Val Gln Gly Ile Gln Glu Ala Ser Trp Leu Ala Leu
 1               5                  10                  15      
Asp Pro Ile Ser His Ser Thr Pro Gly Leu Gly Leu Leu Ser Val Val
            20                  25                  30          
Ser Lys Ala Thr Gly Thr Pro Leu Ala Lys Gln Asn Val Ile Pro Glu
        35                  40                  45              
Ile Cys Ala Leu Leu Cys Met Pro Leu Val Leu Phe Ser Leu Pro Tyr
    50                  55                  60                  
Ser Val Thr Ser Gln Ile Tyr Asn Glu His Leu Pro Arg Thr Met Ser
65                  70                  75                  80  
Gly Leu Gly Gln Gln Thr Ala Pro Ala Val Lys Glu Pro Ala Gly Leu
                85                  90                  95      
Trp Gly Arg His Ala Ile Lys Arg Gln Leu Gln Glu Arg Gln Trp Asp
            100                 105                 110         
Glu Cys Gln Thr Asp Val Ser Ala Lys Tyr Gly Arg Ser Ser Glu Glu
        115                 120                 125             
Ala Ser Ser Leu Val Ala Trp Asp Arg Arg Leu Ala Gly Leu Pro Thr
    130                 135                 140                 
Ser His Pro Ser Pro Pro Cys Ala Leu Leu Pro Glu Cys Leu Pro Glu
145                 150                 155                 160 
His Ser Tyr Pro Ile Cys Glu His Met Val Glu Ser Pro Thr Cys Ser
                165                 170                 175     
Gln Met Ser Asn Leu Val Cys Gly Thr Asp Gly Leu Thr Tyr Thr Asn
            180                 185                 190         
Glu Cys Gln Leu Cys Leu Ala Arg Ile Gly Leu Thr Glu Thr Glu Leu
        195                 200                 205             
Ser Ile Phe Pro Leu Pro Gly Ile Gly Ile Leu Glu Pro Arg Met Ser
    210                 215                 220                 
Thr Ser Ala Ala Lys Ala His Glu Gln Trp His Pro Gly Gly Glu Ala
225                 230                 235                 240 
Gln Glu Ala Asp Leu Val Pro Ala Pro Phe Thr Ala Arg Gly Ala Thr
                245                 250                 255     
Ala Leu Ser Thr Cys Cys Ser Asp His Ser Asp Leu Trp Tyr Pro Val
            260                 265                 270         
Gly Pro Ala His Cys His Ile Ser Pro Glu Cys Leu Pro Arg Ser Ala
        275                 280                 285             
Ser Val Glu Ala Gly Leu Leu Leu Ser Gly Pro Tyr Val Gln Val Phe
    290                 295                 300                 
Ser Val Leu Gly Leu Pro Gly Thr Val Leu Cys Asn Glu Lys His Asp
305                 310                 315                 320 
Leu His Val Thr Ser Gln Gln Gly Ser Ser Glu Pro Val Val Gln Asp
                325                 330                 335     
Leu Ala Gln Val Val Glu Glu Val Ile Gly Val Pro Gln Ser Phe Gln
            340                 345                 350         
Lys Leu Ile Phe Lys Val Leu Leu Cys Pro Asn Arg Asn Pro Asp Gly
        355                 360                 365             
Lys Gly Lys Cys Leu Ala Ile Ser Val Ile Tyr Gln His Glu Asn Ile
    370                 375                 380                 
Thr Val Leu Ile Ile Lys Phe Lys Arg Phe Asn Leu Phe Ala Ile Ser
385                 390                 395                 400 
Ser Pro Pro Arg Lys Asp Lys Leu Ile Leu Pro Ala Phe His Glu Leu
                405                 410                 415     
Pro Pro Asn Ser Arg Leu Ile Ala Phe Ala His Ser Tyr Ser Arg Glu
            420                 425                 430         
His Arg Ser Asp Cys Leu Lys Cys Gly Ser Gly Ala Asp Ser Cys Gly
        435                 440                 445             
Gly Ser Phe Met Thr Gln Gln Gln Leu Asn Cys Gly Arg Asp Ser Ile
    450                 455                 460                 
Ser Val Lys Leu Ala Ser Ser Ala Val Cys Leu Glu Val Phe
465                 470                 475             


<210> 2752
<211> 472
<212> PRT
<213> Homo sapiens

<400> 2752
Met Glu Asp Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His
 1               5                  10                  15      
Phe Ser Lys Leu Thr Ser Pro Arg Pro Asp Ala Ala Phe Ala Glu Ile
            20                  25                  30          
Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg
        35                  40                  45              
Val Asp Leu Cys Asp Tyr Leu Ala Pro Val Ala Arg Gln Leu Ala Pro
    50                  55                  60                  
Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala
65                  70                  75                  80  
Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln
                85                  90                  95      
Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu
            100                 105                 110         
His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met
        115                 120                 125             
Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val Ile Gln
    130                 135                 140                 
Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp
145                 150                 155                 160 
Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys
                165                 170                 175     
Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu
            180                 185                 190         
Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu
        195                 200                 205             
His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala
    210                 215                 220                 
Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu
225                 230                 235                 240 
Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val
                245                 250                 255     
Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His Thr Ser
            260                 265                 270         
Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly
        275                 280                 285             
Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln
    290                 295                 300                 
Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr
305                 310                 315                 320 
Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe
                325                 330                 335     
Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Ile Asp Asp Ala
            340                 345                 350         
Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Thr Gln Gln Ala Tyr
        355                 360                 365             
Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Lys Ser Leu
    370                 375                 380                 
Gln Val Val Glu Thr Val Asn Pro Ser Val Arg Leu Ser Leu Phe Leu
385                 390                 395                 400 
Phe Thr Gln Asn Ser Gln Phe Phe Leu Thr Gln Lys Gln Ile Ser Leu
                405                 410                 415     
Met Glu Lys Lys Phe Ser Ile Ser Gly Pro Ala Gln Ala Arg Pro Ser
            420                 425                 430         
Asn Pro Cys His Leu Ser Leu Cys Gly Ala Leu Gly Gly Gln Arg Arg
        435                 440                 445             
Gly Cys Ser Gly Pro Ser Gly Gly Thr Arg Gly Pro Glu Gly Leu Ser
    450                 455                 460                 
Gly Leu Arg Arg Ile Leu Thr Pro
465                 470         


<210> 2753
<211> 1220
<212> PRT
<213> Homo sapiens

<400> 2753
Met Pro Pro Ala Pro Gln Pro Ala Asp Ala Ala Lys Gly Ala Lys Gly
 1               5                  10                  15      
Gly Gly Val Lys Pro Ala Gly Val Pro Gln Val Lys Leu Gln Gly Pro
            20                  25                  30          
Cys Arg Thr His Pro Glu Trp Arg Val Val Gln Ala Pro Arg Arg Val
        35                  40                  45              
Leu Gly Asp Thr Arg Arg Pro Ala Val Phe Leu Pro His Thr Leu Thr
    50                  55                  60                  
Val Gly Thr Glu Pro Ala Cys His Pro Pro Pro Thr Val Pro Glu His
65                  70                  75                  80  
Gln Val His Gly Ala Arg Ser Gly Val Ser Trp Glu Gly Asp Arg Lys
                85                  90                  95      
Ser Glu Thr Ser Glu Glu Glu Glu Arg Gly Trp Gly Ser Tyr Lys Gly
            100                 105                 110         
Gly Ser Gln Thr Leu Trp Ser Phe Gly Asp Ser Pro Gln Glu Ser Ala
        115                 120                 125             
Gln Gln Gln Ala Pro Trp Gly Thr Ala Ile Gln Leu Arg Gly Thr Leu
    130                 135                 140                 
Gly Gly Arg Gly Gly Gly Arg Phe Thr Ser Met Asp Thr Val Cys Ser
145                 150                 155                 160 
Ser Pro Glu Leu Pro Leu Glu Glu Cys Pro Val Asn Asp Ala Gly Gln
                165                 170                 175     
Asn Val Ser Phe Gly Thr Arg His Phe Pro Asp Ile His His Ser Pro
            180                 185                 190         
Asp Ser Thr His Thr Val Glu Thr Ala Pro Ser Leu Asn Pro Leu Gly
        195                 200                 205             
Ser Leu Cys Trp Cys Ala Pro Ser Ala Pro Ala Trp Thr Arg Leu Ala
    210                 215                 220                 
Leu Leu Val Gly Ala Leu Cys Ser His Leu Asn Ser Thr Arg Ser Ala
225                 230                 235                 240 
Gly Val Arg Pro Leu Leu Pro Pro Gly Leu Asn Ser Leu Cys Cys Leu
                245                 250                 255     
Ser Ser Lys Trp Leu Gly Ala Gln Asp Pro Ala Lys Asp Phe Ala Leu
            260                 265                 270         
Lys Pro Ala Ser Ala Lys Val Ile Asp His Leu Asn Phe Leu Thr Cys
        275                 280                 285             
Pro Met Pro Ser Leu Ala Ser Val Glu Met Asn Lys Pro Gln Ser Thr
    290                 295                 300                 
Pro Pro Leu Cys His Val Gly Gln Pro Ser Gln Ala Ala Val Ser Leu
305                 310                 315                 320 
Ile Leu Thr Ala Leu Gly Pro Val Val Thr Ser Tyr Leu Pro Ser Leu
                325                 330                 335     
Leu Pro Arg Tyr Lys Ile Leu Thr Gly Leu Ser Gln Ala Val Cys Gly
            340                 345                 350         
Pro Cys Cys Gln Glu Gly Tyr Ile Phe Trp Gly Cys Pro Phe Pro Thr
        355                 360                 365             
Gly Asn Pro Pro Cys Pro Pro Ser Cys Thr Gly Ala Pro Val Leu Pro
    370                 375                 380                 
Val Thr Ala Gln Val Phe Gly Ser Pro Leu Pro Ile Pro Ala Ser Arg
385                 390                 395                 400 
Ala Ser Tyr Thr Ala Gly Arg Leu Pro Ala Gln Trp Arg Ser Arg Asp
                405                 410                 415     
Val Lys Met Asn Glu Glu Cys Gly Leu Pro Gly Ala Ser Ala Tyr Gly
            420                 425                 430         
Ile Gly Leu Val Ser Arg Ser Gln Gly Cys Lys Ala Glu Pro Pro Gly
        435                 440                 445             
Pro Ser Pro Thr Gly Met Thr Asp Gly Arg His Gly Pro Pro Pro Pro
    450                 455                 460                 
Gln Leu Ser Gln Pro His Gly Asn Asp Arg Gln Gln Thr Arg Ala Ser
465                 470                 475                 480 
Pro Ser Thr Ala Val Leu Pro Ser Asp Gln Thr Tyr Pro Gly Thr Arg
                485                 490                 495     
Ala Arg Gly Asp Leu Glu Pro Pro His Leu Gln Gly Gln Pro Pro Gly
            500                 505                 510         
Pro Gly Gln Glu Gln Lys Glu Arg Pro Arg Asn Tyr Ser Thr Gly Met
        515                 520                 525             
Pro Pro Thr Asp Pro Arg Lys Gly Gly Leu Gln Val Ala Ala Leu Ala
    530                 535                 540                 
Pro Gln Trp Leu Cys Ser Gln Arg Gln Gln Arg Ala Val Leu Leu Gly
545                 550                 555                 560 
Pro Ser Trp Asn Ser Ala Trp Val Trp Gly Leu Ala Gly Ala Glu Gly
                565                 570                 575     
Glu Glu Trp Ala Ala Gly Gln Asp Asp Gly Ser Lys Asp Cys Gln Arg
            580                 585                 590         
Met Ala Thr Val Ala Glu Ala Ser Glu Asp Gln Thr Leu Pro Glu Ser
        595                 600                 605             
Gly Arg Ala Ala Phe Pro Ala Gly Ala Ser Arg Leu Ser Ala Pro Trp
    610                 615                 620                 
Trp Glu Ser His Ala Thr His Ser Gln Arg Ala Pro Thr Ala Lys Val
625                 630                 635                 640 
Trp Ile Leu Ile Arg Ile Gln Glu Cys Asp Val Met Ser Ser Ser Glu
                645                 650                 655     
Ala Trp Ile Phe Ala Phe Thr Phe Glu Cys Val Asn His Gly Ser Pro
            660                 665                 670         
Gly Ser Leu Glu Met Cys Trp His Ala Trp Asp Leu Ser Trp Ser Glu
        675                 680                 685             
Val Glu Gln Leu Thr Leu Glu Ala Pro His Gln Ala Leu Ile Cys Gln
    690                 695                 700                 
Pro Pro Leu Pro Ala Gly Thr Thr Ile Gly Gln Asp Leu Ser Trp Met
705                 710                 715                 720 
Asp Leu Ile Thr Pro Ser Pro Asp Thr Leu Tyr Ser Gln Pro Gln Leu
                725                 730                 735     
Ser Ala Leu Cys Tyr Ser Ala Arg Asn Asp Asp Arg Asp Asp Tyr Thr
            740                 745                 750         
Pro Thr Arg Glu Ala Pro Gln Gln Arg Val Ile Leu Ala Ser Gln Ser
        755                 760                 765             
Thr Glu Leu Glu Ala Ala Pro Ala Val Gly Thr Asp Trp Glu Pro Thr
    770                 775                 780                 
Lys Asn Ser Gly Arg Arg Lys Gly Ser Gly Ala Gly Gly Thr Arg Val
785                 790                 795                 800 
Val Arg Leu Leu Thr Pro Glu Leu Ala Cys Phe Cys Ser Asn Leu Glu
                805                 810                 815     
Leu Arg Leu Ala Ser Gly Gly Asp Ala Pro His Ile Arg Met Gln Ala
            820                 825                 830         
His Arg Pro Tyr Asn Tyr His Gly His Val Arg Gly Pro Cys Arg Phe
        835                 840                 845             
His Arg Ser Leu Lys Val Gly Phe Ile Ile Val Ser Phe Thr Ser Ile
    850                 855                 860                 
Phe Val Phe Ala Glu Ser Ser Leu Cys Thr Gly Asp Ala Gln Pro Ile
865                 870                 875                 880 
Pro Ser Thr Ala Ala Ser Ile Leu Ala Gly Ala Pro Gly Asp Ser Leu
                885                 890                 895     
Arg Gln Pro Cys His Trp Arg Glu Ser Gly Glu Gln Arg His Ser Gln
            900                 905                 910         
Gly Pro Gln Ala Leu Pro Ala Gly Asn Trp Val Gln Ser Val Asn Arg
        915                 920                 925             
Ser Leu Gly Pro Leu Gln Ser Arg Gly Trp Val Ala Val Gly Leu Glu
    930                 935                 940                 
Phe Ala Ala Ala Trp Pro Pro Tyr Pro Leu Glu Thr Cys Cys Pro Cys
945                 950                 955                 960 
Pro Ala Ile Pro Pro Tyr Leu Leu Pro Thr Ile Trp Phe Asn Pro Thr
                965                 970                 975     
Met Gly Ser Phe Arg Asn Ser Gly Ser Pro Ala Ala His Ser Pro Gly
            980                 985                 990         
Lys Pro Pro Pro Ala His His Lys Gly Leu His Leu Pro Arg Leu Leu
        995                 1000                1005            
Met Ala Pro Ala Leu Gly Ser Glu Gly Gly Ser His Thr Pro Pro Trp
    1010                1015                1020                
Cys Ala Pro Pro Pro Gly Ala Gln His Ile Glu Leu Asn Cys Lys Gln
1025                1030                1035                1040
His Pro Met Gln Leu His Glu His Gln Thr Phe Leu Ser Leu Lys Thr
                1045                1050                1055    
Cys Arg Arg Asp Lys Ser Gly Ser Ala Leu Tyr Asp Ser His Asp Arg
            1060                1065                1070        
Ser Ser Thr Ala Asn Pro Ala Thr Lys Gln Arg Val Pro Gln Ile Lys
        1075                1080                1085            
Ile Pro Ala Gly Gly Ser Glu Leu Gln Gln Asp Lys Gly Trp Ala Phe
    1090                1095                1100                
Trp Asn Asn Pro Ala Ala Gly Trp Gly Ser Glu Val Leu Gly Glu Asn
1105                1110                1115                1120
His Asn Ala Leu Leu Ser Ala Pro Ala Thr Glu Leu Ser Leu Leu Trp
                1125                1130                1135    
Ser Gly Glu Ser Ser Ser Gln Ala Leu Cys Gly Ala Ser Ile Pro Gly
            1140                1145                1150        
Val Ser Ala Gly Gly Pro Ala Leu Ala Gly Ile Pro His Ser His Ala
        1155                1160                1165            
Ser Ser Leu Arg Ile Leu Pro Glu Thr Gln Glu Gln Ala Ala Gly Pro
    1170                1175                1180                
Val Pro Gly Ala Val Gly Pro Met Leu Ala Pro Gln Leu Arg Asp Arg
1185                1190                1195                1200
Phe Arg Val Pro Gly Cys Pro Pro Leu Ser Glu Glu Cys Thr Pro Ile
                1205                1210                1215    
Val Val Lys Pro
            1220


<210> 2754
<211> 793
<212> PRT
<213> Homo sapiens

<400> 2754
Met Ala Arg Glu Leu Ser Gln Glu Ala Leu Leu Asp Phe Leu Cys Gln
 1               5                  10                  15      
Ala Gly Gly Arg Val Thr Asn Ala Ala Leu Leu Ser His Phe Lys Ser
            20                  25                  30          
Phe Leu Arg Asp Pro Asp Ala Ser Ser Ser Gln His Gln His Arg Arg
        35                  40                  45              
Glu Leu Phe Lys Gly Phe Val Asn Ser Val Ala Ala Val Arg Gln Asp
    50                  55                  60                  
Pro Asp Gly Thr Lys Tyr Val Val Leu Lys Arg Arg Tyr Arg Asp Leu
65                  70                  75                  80  
Leu Gly Glu Glu Gly Leu Gln Arg Pro Arg Glu Pro Pro Ala Ala Ala
                85                  90                  95      
Pro Ser Ala Gly Gly Ala Ala Pro Cys Ser Pro Arg Gly Ala Arg Arg
            100                 105                 110         
Gly Glu Pro Pro Gln Gln Gln Pro Arg Arg Arg Arg Arg Glu Lys Glu
        115                 120                 125             
Pro Glu Glu Glu Pro Ala Gly Ala Ala Ala Arg Ala Ala Asp Ala Ala
    130                 135                 140                 
Cys Asn Gly Leu Pro Gly Ser Gly Ser Arg Arg Ala Pro Gly Lys Gly
145                 150                 155                 160 
Gly Gly Ser Lys Gly Ser Pro Gly Gln Arg Pro Pro Val Pro Ala Ala
                165                 170                 175     
Ala Ala Ala Gly Ala Gln Ala Arg Ala Ser Cys Ala Ala Ala Lys Thr
            180                 185                 190         
Gln Gly Arg Cys Cys Trp Glu Cys Leu Gln Asn Asn Leu Ala Val Leu
        195                 200                 205             
Pro Gly Glu Leu Gly Ala Leu Pro His Ser Ala Thr Ala Glu Glu Lys
    210                 215                 220                 
Pro Ala Arg Ala Leu Pro Ala Gln Asp Asp Arg Gly Ala Ser Arg Glu
225                 230                 235                 240 
Arg Glu Glu Gly Ala Leu Ala Glu Pro Ala Pro Val Pro Ala Val Ala
                245                 250                 255     
His Ser Pro Pro Ala Thr Val Glu Ala Ala Thr Ser Arg Ala Ser Pro
            260                 265                 270         
Pro Ala Leu Leu Pro Gly Pro Ala Pro Arg Gly Asp Arg Pro Glu Leu
        275                 280                 285             
Leu Thr Pro Ser Ser Leu His Tyr Ser Thr Leu Gln Gln Gln Gln Gln
    290                 295                 300                 
Arg Thr Arg Glu Trp Val Ala Arg His Pro Gln Val Pro Glu Ala Arg
305                 310                 315                 320 
Asp Gln Gly Pro Ile Arg Ala Trp Ser Val Leu Pro Asp Asn Phe Leu
                325                 330                 335     
Gln Leu Pro Leu Glu Pro Gly Ser Thr Glu Pro Asn Ser Glu Pro Pro
            340                 345                 350         
Asp Pro Cys Leu Ser Ser His Ser Leu Phe Pro Val Val Pro Asp Glu
        355                 360                 365             
Ser Trp Glu Ser Trp Ala Gly Asn Thr Ser Leu Thr Val Phe Arg Ser
    370                 375                 380                 
Ile Arg Cys Gln Leu Ser Leu Gln Asp Leu Asp Asp Phe Val Asp Gln
385                 390                 395                 400 
Glu Ser Asp Gly Ser Glu Glu Ser Ser Ser Gly Pro Lys Asp Ser Pro
                405                 410                 415     
Gly Ala Ser Glu Glu Gly Leu Gln Val Val Leu Gly Thr Pro Asp Arg
            420                 425                 430         
Gly Lys Leu Arg Asn Pro Ala Gly Gly Leu Ser Val Ser Arg Lys Glu
        435                 440                 445             
Gly Ser Pro Ser Arg Ser Pro Gln Gly Leu Arg Asn Arg Gly Asp Gly
    450                 455                 460                 
His Ile Ser Gln Gln Val Pro Ala Gly Ala Asn Gly Leu Ala Gly His
465                 470                 475                 480 
Pro Leu Lys Pro Leu Pro Trp Pro Val Pro Lys Leu Arg Arg Ser Leu
                485                 490                 495     
Arg Arg Ser Ser Leu Ala Gly Arg Ala Lys Leu Ser Ser Ser Asp Glu
            500                 505                 510         
Glu Tyr Leu Asp Glu Gly Leu Leu Lys Arg Ser Arg Arg Pro Pro Arg
        515                 520                 525             
Ser Arg Lys Pro Ser Lys Ala Gly Thr Ala Pro Ser Pro Arg Val Asp
    530                 535                 540                 
Ala Gly Leu Ser Leu Lys Leu Ala Glu Val Lys Ala Val Val Ala Glu
545                 550                 555                 560 
Arg Gly Trp Arg His Ser Leu Trp Val Pro Ser Gly Glu Gly Ser Ala
                565                 570                 575     
Ala Leu Ala Pro His Arg Thr Ser Glu His Lys Ser Ser Leu Val Pro
            580                 585                 590         
Leu Asp Ala Arg Glu His Glu Trp Ile Val Lys Leu Ala Ser Gly Ser
        595                 600                 605             
Trp Ile Gln Val Trp Thr Leu Phe Trp Glu Asp Pro Gln Leu Ala Leu
    610                 615                 620                 
His Lys Asp Phe Leu Thr Gly Tyr Thr Ala Leu His Trp Ile Ala Lys
625                 630                 635                 640 
His Gly Asp Leu Arg Ala Leu Gln Asp Leu Val Ser Gly Ala Lys Lys
                645                 650                 655     
Ala Gly Ile Val Leu Asp Val Asn Val Arg Ser Ser Cys Gly Tyr Thr
            660                 665                 670         
Pro Leu His Leu Ala Ala Ile His Gly His Gln Gly Val Ile Lys Leu
        675                 680                 685             
Leu Val Gln Arg Leu Ala Ser Arg Val Asn Val Arg Asp Ser Ser Gly
    690                 695                 700                 
Lys Lys Pro Trp Gln Tyr Leu Thr Ser Asn Thr Ser Gly Glu Ile Trp
705                 710                 715                 720 
Gln Leu Leu Gly Ala Pro Arg Gly Lys Pro Ile Phe Pro Val Tyr Pro
                725                 730                 735     
Leu Val Gly Ser Ser Ser Pro Thr Arg Lys Ala Lys Ser Lys Glu Ile
            740                 745                 750         
Ser Arg Ser Val Thr Arg Lys Thr Ser Phe Ala Ala Leu Leu Lys Ser
        755                 760                 765             
Gln His Asn Lys Trp Lys Leu Ala Asn Gln Tyr Glu Lys Phe His Ser
    770                 775                 780                 
Pro Arg Glu Arg Glu Glu Tyr Ser Asp
785                 790             


<210> 2755
<211> 308
<212> PRT
<213> Homo sapiens

<400> 2755
Met Gly Gly Ala Asp Glu Val Gly Cys Ile Leu Gln Arg Ala Leu Ala
 1               5                  10                  15      
Lys Ala Glu Gly Phe Arg Leu Val His Ile Gln Gly Arg Ala Ala Asp
            20                  25                  30          
Pro Ala Leu Leu Gln Gly Leu Gly Gln Arg Leu Leu Ile His Gln Ala
        35                  40                  45              
Thr Pro Gly Cys Val His Gln Glu Gly Pro Leu Ser His Leu Leu Asp
    50                  55                  60                  
Gly Glu Val Val Asp Glu Val Val Val Val Leu Val Glu Ala Ala Val
65                  70                  75                  80  
Gln Gly His Ala Val Ala Val Glu Glu Gln Val Leu Gln Gly Ala Asp
                85                  90                  95      
Thr Leu Gln Pro Gln Arg Pro Leu His Ala Ile Arg Gln Val Arg Val
            100                 105                 110         
Val Glu Glu His Val Glu Ala Glu Gly Leu Gly Pro Gln Arg His Cys
        115                 120                 125             
Leu Pro His Ala Pro Ser Pro Met Met Pro Lys Val Ser Pro Arg Ile
    130                 135                 140                 
Leu Ala Ala Pro Asp Ala Thr Ser Arg Ile Cys Ser Thr Leu Trp Thr
145                 150                 155                 160 
Arg Val Pro Ser Arg Ser Ala Trp Cys Ser Gln Val Ala Arg Arg Tyr
                165                 170                 175     
Arg Phe Arg Met Trp His Ser Val Glu Ser Ala Val Ser Ser Thr Asp
            180                 185                 190         
Ala Ala Gly Thr Leu Gln Thr Ala Ile Pro Lys Ser Pro Ala Asp Leu
        195                 200                 205             
Met Ser Met Leu Ser Lys Pro Leu Pro Ile Arg Thr Met Met Arg Arg
    210                 215                 220                 
Ala Leu Asn Phe Ser Arg Ser Ser Leu Val Arg Val Met Val Trp Tyr
225                 230                 235                 240 
Ile Arg Ala Pro Thr Ala Ser Phe Arg Thr Phe Ser Trp Ile Ser Cys
                245                 250                 255     
Val Asp Cys Ala Ser Gln Lys Ala Thr Val Ala Thr Ser Phe Arg Met
            260                 265                 270         
Gly Ile Ser Thr Val Gln Ser Arg Pro Ser Ser Asn Ala Thr Arg Gly
        275                 280                 285             
Arg Gly Cys Arg Gly Pro Phe Met Ile Gly Gly Arg Thr Pro Gln Ala
    290                 295                 300                 
Ala Gly Pro Cys
305             


<210> 2756
<211> 125
<212> PRT
<213> Homo sapiens

<400> 2756
Met Ala Ala Gln Pro Val Ser Pro Pro Gln Lys Pro Ser Pro Ala Ala
 1               5                  10                  15      
Pro Ala Leu Leu Pro Gly Arg Gly Ala Leu Gly Arg Pro Trp Val Pro
            20                  25                  30          
Gly Pro Arg Trp Arg Ser Gly Ile Pro Leu His Leu Thr Pro His Ser
        35                  40                  45              
Arg Leu Cys Pro Pro Ser Gly Gln Thr Arg Ser Pro Trp Lys Arg His
    50                  55                  60                  
Phe Leu His Gln Ser Leu Pro Pro Ser Leu Pro Ala Ser Pro Ala Cys
65                  70                  75                  80  
Ala Gly Ser Asp Trp Arg Pro Arg Cys Cys Leu Ala Val Ser Gln Ser
                85                  90                  95      
Leu Trp Val Arg Leu Pro Gly Thr Leu Pro Gln His His Thr Glu Pro
            100                 105                 110         
Trp Ser Gln Ala Ala Gly Glu Ala Pro Ala Ser Gln Thr
        115                 120                 125 


<210> 2757
<211> 249
<212> PRT
<213> Homo sapiens

<400> 2757
Met Ser Ser Cys Ile Thr Val Trp Gly Arg Met Met Gln Gln Glu Lys
 1               5                  10                  15      
Thr Leu Lys Gln Val Met Asp Ser Pro Ala Phe Leu Glu Ser Lys Glu
            20                  25                  30          
His Phe Pro Leu Trp Met Leu Thr Val Gln Ala Arg Leu Gly Ser Arg
        35                  40                  45              
Val Arg Gln Phe Ile Leu Cys Asn Tyr Lys Asn Glu Gln Arg Ala Phe
    50                  55                  60                  
Lys His Val Ser Lys Leu Gln Lys Ala Ser Asn Leu Gly Ile Glu Phe
65                  70                  75                  80  
Pro Ile Ser Ser Asp Tyr Arg Ile Cys Ala Glu Asn Leu Asp Ile Lys
                85                  90                  95      
Lys Leu Asp Ile Lys Ile Met Glu Ile Asp Ile Lys Gln Asp Thr Glu
            100                 105                 110         
Phe Glu Glu Thr Tyr Arg Arg Lys Arg Ser His Trp Asn Leu Lys Asn
        115                 120                 125             
Arg Met Glu Arg Ile Lys Ala Val Leu Arg Val Leu Ser Pro Glu Leu
    130                 135                 140                 
Ser Ile Lys Gly Lys Asn Gly Thr Leu Lys Val Phe Glu Ile Val Gln
145                 150                 155                 160 
Ile Lys Arg Lys Ile Ser Ser Ala Glu Ser Phe Tyr Phe Thr Phe Ser
                165                 170                 175     
Leu Pro Ala Gly Arg Lys Met Gly Leu Gln Lys Arg Leu Leu Glu Val
            180                 185                 190         
Asn Glu Asn Ser Leu Arg Asn Ile Lys Arg Phe Trp Met Leu Gln Ala
        195                 200                 205             
Ala Ala Arg Gly Ser Glu Ser Glu Leu Arg Met Leu Leu Glu Asp Glu
    210                 215                 220                 
Gly Ile Ser Ser Tyr Gly Gly Ile Trp Gln Pro Asn His Met Val Asn
225                 230                 235                 240 
Phe Pro Leu Lys Thr Phe Ala Lys Cys
                245                 


<210> 2758
<211> 792
<212> PRT
<213> Homo sapiens

<400> 2758
Met Leu Arg Ser Phe Leu Arg Gly Asn His Ala Ala Pro Ala Leu Leu
 1               5                  10                  15      
Ser Gln Ala Ala Ser Ala Cys Ile Ser Lys Tyr Ser Arg Phe Arg Glu
            20                  25                  30          
Tyr Arg Gly His Glu Ala Gln Lys Asn Thr Lys Pro Met Lys Gln Arg
        35                  40                  45              
Ile Leu Arg Ala Lys Ile Gln Ile Ser Lys Arg Trp Ile Leu Gln Met
    50                  55                  60                  
Glu Thr Leu Arg Glu Leu Arg Gln Arg Arg Cys Glu Glu Asn Lys Tyr
65                  70                  75                  80  
Glu Ser Leu Pro Pro Gly Pro Gly Leu Gln Pro Ser Ala Pro Phe Arg
                85                  90                  95      
Val Glu Ser Pro Ile Ala Ala Ala Cys Ser Tyr Ser Thr Ile Pro Val
            100                 105                 110         
Pro Arg Leu Ser Leu His Asp Leu Gly Ser Ala Pro Ser Gln Gln Arg
        115                 120                 125             
Pro Arg Pro Pro Ser Pro Leu Ser Val Cys Gly Ser Arg Pro Ile Phe
    130                 135                 140                 
Leu Ser Leu Gly Glu Thr Pro Ser Cys Thr Leu Glu His Gln His Gly
145                 150                 155                 160 
Glu Gly Arg Ala Ser Thr Cys Leu Cys Ala Leu Leu Asp Pro Val Leu
                165                 170                 175     
Gly Pro Ser Thr Arg Ala Thr Val Thr Arg Thr Ala Asp Phe Arg Asp
            180                 185                 190         
Thr Ala Val Val Lys Ile Lys Glu Arg Lys Asn Glu Gln Lys Glu Arg
        195                 200                 205             
Cys Leu Gln Ala Phe Arg Asp Phe Lys Ala Ile Leu Pro Val Phe Phe
    210                 215                 220                 
Lys Arg Ser Ser Leu Ala Phe Pro Asn Ile Ser Ser Ile Asn Thr Leu
225                 230                 235                 240 
Gln His Leu His Leu Gln Arg Phe Leu Tyr Ser Asp Cys Pro Ala Ile
                245                 250                 255     
Gly Ala Ala Cys Tyr Arg Asn Thr Ala Asn His Val Ser His Thr Ile
            260                 265                 270         
Val Lys Thr Leu Ala His Ile Gly Lys Thr Gly Val Val His Phe Met
        275                 280                 285             
Glu Ser Ile Leu His Leu Met Asn Gly Phe Gly Tyr Gln His Ser Pro
    290                 295                 300                 
Phe Ile Glu Trp Glu Glu Tyr Trp Leu Ser Val Ser Glu Val Lys Ser
305                 310                 315                 320 
Ile Lys Gly Asp Asn Leu Tyr Gly Gly Ser Pro Thr Gln Ser Pro Ala
                325                 330                 335     
Asp Asn Glu Gln Thr Leu His Lys Gly Lys Pro Ser Tyr Gly Lys Pro
            340                 345                 350         
Asn Ala Tyr Ile Ala Asn Tyr Phe Phe Leu Asn Leu Leu Gln Ile Leu
        355                 360                 365             
Thr Ala Ala Trp Arg Cys Met Thr Thr Trp Glu Ala Asp Pro Glu Gly
    370                 375                 380                 
Val Arg Asn Gln Ala Gly Asp Asn Ala Ala Lys Glu Leu Val Leu Ala
385                 390                 395                 400 
Cys Val Tyr Leu Ser Cys Lys Thr Ser Leu Thr Gln Arg Gly Arg Ala
                405                 410                 415     
Thr Gln Ile His Thr Leu Ala Pro Arg Leu Arg Val Trp Ser Val His
            420                 425                 430         
Val Val Cys Leu Ser Gly Tyr His Arg Ala Gln Ser Ser Lys His Phe
        435                 440                 445             
Thr His Arg Ala Gln Ser Ser Lys His Phe Thr His Arg Ala Gln Ser
    450                 455                 460                 
Ser Lys His Phe Thr His Arg Gly Gln Ser Ser Lys Arg Phe Thr His
465                 470                 475                 480 
Arg Ala Gln Ser Cys Lys His Phe Thr His Arg Ala Gln Ser Ser Lys
                485                 490                 495     
Arg Phe Thr His Arg Ala Gln Ser Ser Lys Arg Phe Thr His Arg Gly
            500                 505                 510         
Gln Tyr Ser Lys Arg Phe Thr His Arg Ala Gln Ser Ser Lys Arg Phe
        515                 520                 525             
Thr His Arg Ala Gln Ser Cys Lys Arg Phe Thr His Arg Ala Gln Ser
    530                 535                 540                 
Cys Lys Arg Phe Thr His Arg Ala Gln Ser Ser Lys Arg Phe Thr His
545                 550                 555                 560 
Arg Ala Gln Ser Ser Lys Arg Phe Thr His Arg Ala Gln Ser Cys Lys
                565                 570                 575     
Arg Phe Thr His Arg Ala Gln Ser Cys Lys Arg Phe Thr His Arg Ala
            580                 585                 590         
Gln Ser Cys Lys Arg Phe Thr His Arg Gly Gln Tyr Ser Lys Arg Phe
        595                 600                 605             
Thr His Arg Gly Gln Tyr Ser Lys Arg Phe Thr His Arg Gly Gln Tyr
    610                 615                 620                 
Ser Lys Arg Phe Thr His Arg Gly Gln Tyr Ser Lys Arg Phe Thr His
625                 630                 635                 640 
Arg Ala Gln Ser Ser Lys Arg Phe Thr His Arg Ala Gln Ser Ser Lys
                645                 650                 655     
Arg Phe Thr His Arg Gly Gln Ser Cys Lys His Phe Pro Ala His Asn
            660                 665                 670         
Lys Ala His Cys Gly Gln Val Leu Gly Pro Val Val Ser Ala Ser Glu
        675                 680                 685             
Leu Gln Val Val Val Leu Ala Leu Ser Val Ala Gly Lys Leu Ser Cys
    690                 695                 700                 
Arg Tyr Lys Glu Val Val Glu Tyr Ile Leu Ala Ser Thr Thr Cys Phe
705                 710                 715                 720 
Ala Gly Arg Val Glu Leu Ser Thr Val Pro Trp Glu Ser Glu Asp Arg
                725                 730                 735     
Phe Thr Leu Trp Gly His Gly Lys Gln Asn Ile Thr Val Glu Ala Ala
            740                 745                 750         
Pro Lys Pro Lys Thr Trp Asp Thr Lys Phe Thr Arg Leu Phe Cys Asn
        755                 760                 765             
His Glu Lys Ser Asn Asp Gly Lys Met Glu Pro Ala His Thr Pro Thr
    770                 775                 780                 
Leu Glu Ser Pro Leu Ala Leu Val
785                 790         


<210> 2759
<211> 803
<212> PRT
<213> Homo sapiens

<400> 2759
Met Leu Ser Phe Ser Asn Ile Thr Leu Val Asn Ile Trp Ser Pro Asp
 1               5                  10                  15      
Ser Arg Phe Ala Cys Pro Pro Asp Ala Pro Gly Arg Arg Trp Ala Leu
            20                  25                  30          
Ala Pro Ala Leu Thr Ala Gln Pro Glu Pro Arg Gly Gln Val His Val
        35                  40                  45              
Pro Leu Leu Pro Cys Leu His Leu Gly Ala Pro Glu Phe Pro Lys Asp
    50                  55                  60                  
Thr Gly Ile Gln Ser Gln Pro Glu His Pro Ile Ala Lys Leu Gly Val
65                  70                  75                  80  
Ser Pro Thr Asn Trp Arg His Cys Leu Phe Glu Gly Val Val Tyr Val
                85                  90                  95      
Thr Gly Ile Val Ser Glu Glu Leu Ile Ala Ser His Pro Lys Thr Asp
            100                 105                 110         
Ser Lys Tyr Lys Glu Gly Asn Ser Gln Ile Pro Gln Ile His Gln Lys
        115                 120                 125             
Lys Leu Ser Thr Ala Ala Pro Thr Val Gly Cys Ser Pro Ser Glu Pro
    130                 135                 140                 
Arg Thr Gly Pro Ile Pro Arg Met Ala Pro Arg Met Ala Gln Leu Ser
145                 150                 155                 160 
Thr Ala Ala Pro Ala Ala Cys Arg Gly Val Gln Asp Asp Val Thr Arg
                165                 170                 175     
Ser Pro Arg Ser Ile Gln Thr Val Ser Ile Asn Thr Pro Cys Leu Leu
            180                 185                 190         
Gln Thr Arg Ser His Cys Val Lys Ser Ser Ala Gln Gly His Cys Thr
        195                 200                 205             
Gly Val Val Ile Gln Ala Lys Phe Val Asn Met Asn Glu Asp Tyr Asn
    210                 215                 220                 
Phe Cys His Val Arg Thr Asn Ile Leu His Ile Lys Glu Lys Tyr Ser
225                 230                 235                 240 
Asn Lys Lys Thr Leu Lys Gln His Arg Lys Ala Phe Lys Phe Ile Val
                245                 250                 255     
Tyr Trp Val Gln Arg Gly Phe Arg Arg Leu Leu Arg Lys Glu Phe Val
            260                 265                 270         
Val Gly Thr Arg Leu Gly Phe Arg Tyr Thr Ser Lys Ser Tyr Lys Glu
        275                 280                 285             
Gly Leu Gly Val Glu Lys Gln Lys Ala Asn Tyr Lys Glu Val Leu Cys
    290                 295                 300                 
Gly Pro Glu Val Ser Ser Thr Gln Trp Lys Asn Lys Cys Asp Ser Asp
305                 310                 315                 320 
Ser Ala Gly Val Ala Arg Leu Gln Thr Ala Ala Ile Val Ala Val Glu
                325                 330                 335     
Glu Leu Asp Ser Thr Pro Pro Cys Trp Gln His Ala Ser Leu Glu Met
            340                 345                 350         
Ser Leu Ala Glu Ser Ala Glu Lys Arg Ala Ala Lys Leu Phe Trp Glu
        355                 360                 365             
Lys Arg His Asp Trp Gln Phe Glu Thr Ser Pro Gly Leu Ser Leu Ser
    370                 375                 380                 
Gln Ala Gln Ser Ser Ser Val Cys Gly Lys Ala Leu Tyr Phe Met Arg
385                 390                 395                 400 
Ala Gly Ala Asn Asp Ser Asn Pro Asn Leu Lys Gly Gly Phe Thr Pro
                405                 410                 415     
Gln Tyr Phe Thr His Leu Gly Cys Ser Thr Ser Lys Gln Ala Cys Ala
            420                 425                 430         
Ile Ala Val Lys Thr Cys Leu Arg Ser Gln Asp Gly Pro Ala His Asn
        435                 440                 445             
Ala Lys Gly Phe Ala Glu Ser Leu Leu Cys Pro Arg Asp Ala Glu Leu
    450                 455                 460                 
Ser Trp Lys Gln Ala Leu Ser Thr Val Leu Lys Arg Lys His Thr Ser
465                 470                 475                 480 
Arg Gln Ile Asn Ser Ser Thr Val Gly Gly Cys Asp Ser Arg Arg Met
                485                 490                 495     
Gly Asn Gly Gln Lys Lys Pro Ile Ala Asn His His Ser Phe Thr Gly
            500                 505                 510         
Ala Gly Ser Asp Ser His Val Ser Asp Pro Glu Asp Pro Gly Gly Thr
        515                 520                 525             
Ala Leu Ile Asn Gly Leu Leu His Phe Leu Ala Leu Ser Ser Val Gln
    530                 535                 540                 
Pro Ala Gly His Pro His Arg Arg Gln Arg Arg Lys Leu Gly Val Leu
545                 550                 555                 560 
Pro Leu Ala Pro Ala Thr Gly Trp His Ala Ser Arg Gly Ala Gly Gly
                565                 570                 575     
Arg His His Ala Ala His Ala Pro Gly Gly Thr Glu Ala Asp Ile Met
            580                 585                 590         
Leu Pro Met Leu Leu Val Ala Gln Arg Pro Thr Ser Cys Cys Pro Cys
        595                 600                 605             
Ser Trp Trp His Arg Gly Arg His His Ala Ala Arg Ala Pro Asp Gly
    610                 615                 620                 
Thr Glu Ala Asp Ile Met Leu Pro Val Leu Leu Met Ala Gln Arg Pro
625                 630                 635                 640 
Thr Ser Cys Cys Pro Cys Ser Trp Trp His Arg Gly Arg His His Ala
                645                 650                 655     
Ala Arg Ala Pro Gly Gly Thr Glu Ala Asp Ile Met Leu Pro Thr Gly
            660                 665                 670         
Leu Leu Thr Val Ala Gln Thr Gly Leu His Asp Gly His Thr Asp Arg
        675                 680                 685             
Pro Pro Asp Gly His Thr Asp Arg Pro Ala Glu Arg Ser Ser Tyr Thr
    690                 695                 700                 
Asp Arg Phe Pro Gln His Gly Arg His Met Glu Arg Ile Val Lys Pro
705                 710                 715                 720 
Arg Glu Ile Ser Ala Gln Thr Ser Lys Leu Glu Met Lys His Lys Thr
                725                 730                 735     
Val Pro Phe Arg Ser Val Gly Gly Asn Leu Phe Gly Pro Ala Phe Arg
            740                 745                 750         
Phe Trp Cys His Arg Leu Phe Asn Lys Asp Asp Ser Ser Ser Asn His
        755                 760                 765             
Gln Arg Gln Gly Ala Thr Ser Leu Asn Thr Ser Glu Cys Thr Gly Leu
    770                 775                 780                 
Lys Glu Glu Phe Pro Lys Asn Ile Val Ser Gly Glu Leu Arg Leu Gly
785                 790                 795                 800 
Arg Ile Phe
            


<210> 2760
<211> 41
<212> PRT
<213> Homo sapiens

<400> 2760
Met Cys Glu Gln Leu Gly Trp Pro Lys Gly Glu Ile Trp Gly Lys Gln
 1               5                  10                  15      
Thr Phe Thr Ile Leu His Trp Pro His Gly Thr Cys Arg Asn Glu Gly
            20                  25                  30          
Val Arg Glu Asp Ser Gly Leu Leu Pro
        35                  40      


<210> 2761
<211> 159
<212> PRT
<213> Homo sapiens

<400> 2761
Met Val Leu Ser Glu Val Met Asp Ala Glu Asp Gly Val Asp Leu Thr
 1               5                  10                  15      
Ile Thr Leu Gln Thr His Ser Phe Ile Ile Asp Ile Glu Ile Leu Lys
            20                  25                  30          
Ile Val His Val Asp Lys Lys Tyr Asn Tyr Phe Asn Ser Ile Glu Ile
        35                  40                  45              
Pro Leu Lys Glu Glu Lys Asp Ser Glu Tyr Ala Ser Ala Gly Cys Val
    50                  55                  60                  
Gln Lys Leu Glu Leu Phe Leu Ser Glu Gly Tyr Asn Phe Val Thr Trp
65                  70                  75                  80  
Ala Leu Ser Thr Lys Pro Ala Arg Thr Asp Ser Glu Leu Tyr Asp Cys
                85                  90                  95      
Val Tyr Gly Gln Gly Thr Trp Glu Glu Phe Glu Ala Val Val His Gly
            100                 105                 110         
Asp Pro Gln Met Gly Arg Asp Phe Leu Glu Thr Glu Leu Gln Pro Lys
        115                 120                 125             
Pro Arg Ser Leu Lys Lys Val Leu Val Ala Met Glu Glu Ser Phe Pro
    130                 135                 140                 
Gln Lys Pro Gly Gln Met Phe Leu Glu Val Ser Ser Gln Gln Lys
145                 150                 155                 


<210> 2762
<211> 234
<212> PRT
<213> Homo sapiens

<400> 2762
Met Gly Leu Trp Ile Glu Glu Val Thr Asp Leu Pro Val Ser Gly Ala
 1               5                  10                  15      
Glu Arg His Leu Lys Glu Gly Leu Tyr Ile Ala Pro Pro Val Lys Arg
            20                  25                  30          
Gln Ile Leu Lys Leu Arg Thr Phe Thr Glu Gly Arg Gly Ser Lys Arg
        35                  40                  45              
Leu Asn Trp Asn His Leu His Ile Gly Arg Arg Asn Val Met Gly Leu
    50                  55                  60                  
Arg Phe Glu Lys Ile Asn Phe Lys Ala Met Thr Ala Thr Ser Gly Trp
65                  70                  75                  80  
Thr Ser Ala Gly Ser Gly Glu Ala His Ala Trp Pro Thr Gly Ser Leu
                85                  90                  95      
Val Gln Phe Cys Ala Arg His Gly Glu Val Phe Pro Leu Ser Ser His
            100                 105                 110         
Asn Glu Gly Asp Ser Ser Pro Glu Val Ala Lys Pro Met Ser Ser Lys
        115                 120                 125             
Gly Thr Val Ala Gln Leu His Gln Val Ala Leu Ser Thr Asp Asp Ser
    130                 135                 140                 
Leu Ile Trp Leu Lys Arg Met Met Lys Asn Val Met Asp Glu Pro Phe
145                 150                 155                 160 
Ala Thr Val Lys Leu Cys Met Gln Ser Gln Cys Glu Thr Asn Arg Thr
                165                 170                 175     
Val Leu Pro Ser Lys Glu Gly Asn Val Met Glu Ala Leu Lys Leu Ser
            180                 185                 190         
Gly Arg Leu Leu Leu Val Asn Ser Met Phe Phe Ser Ile Pro Phe Trp
        195                 200                 205             
Gly Leu Thr Leu Ile Ser Val Pro Pro Asp Leu Thr Ile Leu Ile Lys
    210                 215                 220                 
Lys Lys Val Lys Ser Gln Gly Asn Val Leu
225                 230                 


<210> 2763
<211> 217
<212> PRT
<213> Homo sapiens

<400> 2763
Met Ala Ala Gln Cys Val Arg Leu Ala Arg Arg Ser Leu Pro Ala Leu
 1               5                  10                  15      
Ala Leu Ser Leu Arg Pro Ser Pro Arg Leu Leu Cys Thr Ala Thr Lys
            20                  25                  30          
Gln Lys Asn Ser Gly Gln Asn Leu Glu Glu Asp Met Gly Gln Ser Glu
        35                  40                  45              
Gln Lys Ala Asp Pro Pro Ala Thr Glu Lys Thr Leu Leu Glu Glu Lys
    50                  55                  60                  
Val Lys Leu Glu Glu Gln Leu Lys Glu Thr Val Glu Lys Tyr Lys Arg
65                  70                  75                  80  
Ala Leu Ala Asp Thr Glu Asn Leu Arg Gln Arg Ser Gln Lys Leu Val
                85                  90                  95      
Glu Glu Ala Lys Leu Tyr Gly Ile Gln Ala Phe Cys Lys Asp Leu Leu
            100                 105                 110         
Glu Val Ala Asp Val Leu Glu Lys Ala Thr Gln Cys Val Pro Lys Glu
        115                 120                 125             
Glu Ile Lys Asp Asp Asn Pro His Leu Lys Asn Leu Tyr Glu Gly Leu
    130                 135                 140                 
Val Met Thr Glu Val Gln Ile Gln Lys Val Phe Thr Lys His Gly Leu
145                 150                 155                 160 
Leu Lys Leu Asn Pro Val Gly Ala Lys Phe Asp Pro Tyr Glu His Glu
                165                 170                 175     
Ala Leu Phe His Thr Pro Val Glu Gly Lys Glu Pro Gly Thr Val Ala
            180                 185                 190         
Leu Val Ser Lys Val Gly Tyr Lys Leu His Gly Arg Thr Leu Arg Pro
        195                 200                 205             
Ala Leu Val Gly Val Val Lys Glu Ala
    210                 215         


<210> 2764
<211> 639
<212> PRT
<213> Homo sapiens

<400> 2764
Met Gly Met Pro Pro Ser Glu Pro Pro Pro Arg Gly Pro Tyr Val Gly
 1               5                  10                  15      
Pro Gly Val Lys Leu Lys Val Leu Lys Phe Arg Glu Val Ala Arg Gln
            20                  25                  30          
Ala Pro Arg Gln Lys Ala Arg Gly Leu Asp Gly Phe Phe Leu Glu Asp
        35                  40                  45              
Gly Ala Leu Ser Leu Ser Ser Gly His Gly Glu Lys Trp Gln Arg Pro
    50                  55                  60                  
Glu Gln Lys Asp Ile Gly Gln Gly Pro Gly Ala Gly Gln Ile Tyr Thr
65                  70                  75                  80  
Pro Tyr His Pro Pro Glu Arg Ile Leu Gln Lys Pro Gln Arg Pro Gly
                85                  90                  95      
Ser Gln Thr Pro Ala Asn Gly Leu Val Asp Leu Gly Asn Leu Glu Glu
            100                 105                 110         
Ala Arg Gln Gly Asp Ile Glu Ser Gly Ser Gly Val Lys Ser Ala Phe
        115                 120                 125             
Gly Gly Gly Leu Glu Leu Arg Gly Pro Pro Gly Gly Lys Ala Pro Glu
    130                 135                 140                 
Asp Ile Leu His Leu Leu Cys Pro Leu Lys Ala Gln Gln Thr Ala Arg
145                 150                 155                 160 
Gly Leu Gln Arg Val Gly Lys His Trp Pro Cys Arg Phe Pro Gly Pro
                165                 170                 175     
Ser Pro Ala Ser Pro Gly Gly Gly Leu Asp Ser Cys His Leu Asn Arg
            180                 185                 190         
Ser Pro Ala Ile Pro Leu His Pro Asn Ile Gly Glu Leu Gln Ala Leu
        195                 200                 205             
Glu Val Leu Asp Gln Pro Glu Pro Gly Leu Ile Trp Glu Ser Asp Pro
    210                 215                 220                 
Gly Gln Pro Ala Gln Arg Glu Phe Arg His Pro Glu Leu Ser Leu Val
225                 230                 235                 240 
Ala Thr Met Gly Thr Lys Leu Arg Ala Pro Lys Leu Glu Arg Val Asp
                245                 250                 255     
Ile Gly Arg Gly Asp Leu Cys Glu Cys Leu Pro Ser Leu Leu Gln Ser
            260                 265                 270         
Thr Pro Cys Ile Thr Gln Ser Thr Arg Pro Gly Pro Gly Val Thr Leu
        275                 280                 285             
Ser Ser Ala Gln His Cys Gln Glu Gly Arg Arg Lys Glu Val Arg Ile
    290                 295                 300                 
Lys Asp Gly Ser Ser Asp Pro Asp Asp Phe Phe Ile Ser Ile Ala Pro
305                 310                 315                 320 
Gln Arg Gly Leu Ala Thr Val Met Cys Thr Asn Ala Glu Gln Ile His
                325                 330                 335     
Asn Thr Val Thr Tyr Asn Trp Gly Ser Val Asn Gln Pro Ser Asp Gly
            340                 345                 350         
Pro Cys His Gln Ser Ile Glu Pro Ala Ser Ser Gln Gln Arg Arg Gly
        355                 360                 365             
Trp Gln Trp Lys Pro Asp Pro Lys Gly Lys Ala His Pro Ser Ser Ser
    370                 375                 380                 
Trp Ala Pro Glu Pro Leu Gln Gln Arg Gln Ser Tyr Ala Glu His Trp
385                 390                 395                 400 
Pro Met Gln Asp Met Ala Lys Val Leu Leu Met Asn Ser Phe Asn Leu
                405                 410                 415     
Thr Thr Asn Leu Trp Gly Glu Glu Gln Phe Gln Ala Asp Pro Thr Thr
            420                 425                 430         
Asp Ala Ala Glu Gly Gly Arg Gly Gly Thr Gln His Tyr Gln Glu Asn
        435                 440                 445             
His Cys Ser Leu Arg Thr Tyr Tyr Asp Ala Arg Pro Ile Val Arg Asp
    450                 455                 460                 
Leu Leu Asp Ile His Asp Gly Cys Asp Arg His Trp Asn Ala His Lys
465                 470                 475                 480 
Asp Thr Ala Pro Ser Arg Ala Phe Ser Ser Ser Ala Val Pro Thr Leu
                485                 490                 495     
Pro Gly Cys Cys Gln Leu Pro Asn Ala Arg Ala Ala Thr Trp Gly Pro
            500                 505                 510         
Gly Asp Thr Arg Ala His Thr Val Val Met Cys Leu Asp Gly Glu Cys
        515                 520                 525             
Val Arg Cys Gln Arg Tyr Gln Ala Arg Arg Pro Glu Gly Gly Arg Trp
    530                 535                 540                 
Glu Arg Glu Glu Ala Pro Ala Leu Pro Ala Pro Ser Leu Thr Arg Gly
545                 550                 555                 560 
Leu Arg Lys Glu Gln Arg Val Ser Trp Gly Gln Thr His Ser Ile His
                565                 570                 575     
Ala Pro Ala Gly Ser Thr His Val Arg Thr Ser Ala Pro Ser Ala Gln
            580                 585                 590         
Ala His Trp Arg Ser Gly Pro Asp Leu Leu Arg Glu Arg Glu Thr Trp
        595                 600                 605             
Met Glu Lys Ser Asp Glu Gln Ile Pro Leu Asp Ile Pro Asn Pro Pro
    610                 615                 620                 
Phe Arg Glu Pro Cys Glu Asp Ala Arg Ile Ser Pro Phe Tyr Gly
625                 630                 635                 


<210> 2765
<211> 189
<212> PRT
<213> Homo sapiens

<400> 2765
Met His Phe Arg Ile Thr Ala Pro Thr Gln Thr Pro Thr Arg Leu Cys
 1               5                  10                  15      
Thr Cys Ser Gly Leu Gln Asp Arg Glu Trp Val Glu Gly Glu Glu Asp
            20                  25                  30          
Ile Gly Val Ala Pro Val Lys Leu Ser Thr Ala Arg His Cys Asn Lys
        35                  40                  45              
Glu Thr Phe Leu Ile Val Gln Arg Gly Asp Ser Ala Gly Asn His Pro
    50                  55                  60                  
Pro Pro Ile Tyr Ser Ser Glu Met Cys Cys Arg Arg Val Ala Ser Ser
65                  70                  75                  80  
Ile Leu Gln His Phe Ser Thr Gly Glu Tyr Gly Val Lys His Arg Glu
                85                  90                  95      
Gly Pro Val Ala Gly Val Lys Gln Gln Ile Arg Glu Leu Ser Ser Leu
            100                 105                 110         
Ala Ala Glu Cys Ser Lys Ser Gln Thr Gln Thr Ile Ser Ala Ile Pro
        115                 120                 125             
Glu Trp Pro Gly Lys Val Leu Asp Ser Ser His Ser Gly Gly His Ser
    130                 135                 140                 
Lys Cys Leu Asn Glu Ala Ala Thr Ala Asp Val His Arg Asp Gly Lys
145                 150                 155                 160 
Glu Lys Asn Ala Arg Asn Val Phe Thr Ile Cys His Glu Ala Ser Thr
                165                 170                 175     
Ala Thr Ser Val Leu His Ser Glu Lys Pro Ala Arg Arg
            180                 185                 


<210> 2766
<211> 109
<212> PRT
<213> Homo sapiens

<400> 2766
Met Glu Tyr Gly Phe Glu Leu Met Ser Cys Ile Gly Ala Lys Glu Gly
 1               5                  10                  15      
Ser Val Leu Ala Ser Trp Leu Val Glu Ser Thr His Gly His Asp Ala
            20                  25                  30          
Pro Asn Thr Leu Thr Gln Arg Gln Thr Gln Ala Arg Val Leu Asp His
        35                  40                  45              
Asp Phe Leu Lys Ser Lys Phe His Gln Val Gln Asn Ser Leu Leu Cys
    50                  55                  60                  
Ile Trp Cys Ser Ile Leu Arg Val Ile Arg Phe Cys Gln Ser Ala Gly
65                  70                  75                  80  
Gln Asp Arg Arg Ile Lys Gly Arg Leu Ser Ser Ser Gly Gly Glu Asp
                85                  90                  95      
Gly Thr Gly Glu Gly Glu Leu Arg Thr Ala Gln Asn Glu
            100                 105                 


<210> 2767
<211> 627
<212> PRT
<213> Homo sapiens

<400> 2767
Met Lys Gly Arg Lys Asp Val Asp Trp Asn Leu Leu Cys Leu Glu Asn
 1               5                  10                  15      
Asn Lys Lys Leu Asp Cys Gly Ser Ala Val Ser Ser Pro Leu Leu Ser
            20                  25                  30          
Trp Leu Leu Phe Thr Glu Leu Lys Leu Glu Asp Lys His Ile Pro Tyr
        35                  40                  45              
Leu Arg Ala Val Phe Ser Asp Ala Asp Ser Glu Met Lys Glu Arg Ser
    50                  55                  60                  
Arg Gly Arg Trp Met Met Gly Arg Glu Gly Glu Lys Ala Lys Gln Gly
65                  70                  75                  80  
Thr Val Val Tyr Glu Lys Phe Gln Lys Gly Asp Val Gly Leu Ile Leu
                85                  90                  95      
Gln Glu Asn Ser Arg Val Arg Ile Met Ser Pro Ser Phe Ser Gln Thr
            100                 105                 110         
Arg Gln Trp Ile Arg Ala Phe Pro Leu Leu Cys Gln Ser Leu Ala Asn
        115                 120                 125             
Gly Cys Ala Gly Arg Met Gln Pro Leu Arg His Phe Trp Phe Ser Gly
    130                 135                 140                 
Leu Gln Thr Met Gly Gln Ser Ser Glu Arg Val Thr Arg Val Thr Ile
145                 150                 155                 160 
Asp Trp Gln Tyr Val Ile Pro Ser Phe Ala Asp Glu Ile His Arg Lys
                165                 170                 175     
Ile Arg Asn Ser Phe Ala Lys Ala Leu Ser Gly Cys Val Leu Ile Arg
            180                 185                 190         
Arg Asn Asn Thr Gln Ser Gly Val Arg Ser Arg Leu Ser Lys Gly Lys
        195                 200                 205             
Val Tyr Asp Pro Ser Ile His Pro Ala Ala Gly Thr Pro Phe Lys Thr
    210                 215                 220                 
Gly Ile Ile Ala Ile Glu Ser Arg Ala Ser Ser Val Gly Pro Pro Gly
225                 230                 235                 240 
Asp Arg Leu Pro Lys Ala Asn Asp Asp Leu Gly Gln Pro Ala Arg Pro
                245                 250                 255     
Pro Ala Ala Ala Val Gly Asp Leu Arg Ala Arg Pro Gly Leu Ser Ala
            260                 265                 270         
Pro His Ala His Asp His His Arg Thr Arg Ala Pro Leu Leu Ala Ala
        275                 280                 285             
Ser Val Tyr Ala Gly Ala Arg Gly Ser Gly Ser Arg Ile Ser Val Ser
    290                 295                 300                 
Cys Ser Thr Ser Phe Arg Gly Gly Leu Gly Ser Arg Gly Leu Ala Lys
305                 310                 315                 320 
Trp Met Ala Gln Gly Leu Ala Gly Met Gly Gly Ile Gln Asn Lys Glu
                325                 330                 335     
Thr Leu Gln Ser Leu Asn Asn His Leu Ala Ser Tyr Leu Asp Arg Val
            340                 345                 350         
Arg Ser Leu Glu Thr Lys Asn Gln Arg Leu Glu Ser Asn Thr Arg Glu
        355                 360                 365             
His Leu Glu Lys Lys Gly Pro Gln Val Arg Asp Trp Gly His Tyr Phe
    370                 375                 380                 
Lys Thr Ile Glu Asp Leu Arg Ala Gln Ile Phe Ala Asn Thr Val Asp
385                 390                 395                 400 
Asn Ala Cys Ile Val Leu Gln Ile Asp Asn Ala Tyr Leu Ala Ala Asp
                405                 410                 415     
Gly Phe Arg Val Lys Cys Glu Thr Glu Leu Ala Met Cys Gln Ser Val
            420                 425                 430         
Glu Asn Asp Ile Arg Gly Leu Cys Lys Leu Glu Thr Asp Ile Glu Ala
        435                 440                 445             
Leu Arg Glu Glu Leu Leu Leu Met Lys Glu Asn His Glu Glu Glu Val
    450                 455                 460                 
Lys Gly Leu Gln Ala Gln Leu Thr Ser Ser Gly Leu Thr Val Lys Val
465                 470                 475                 480 
Asp Ala Pro Lys Ser Gln Asp Leu Ala Lys Ile Met Ala Asp Ile Gln
                485                 490                 495     
Ala Gln Tyr Asp Glu Leu Ala Gln Lys Asn Gln Glu Glu Leu Asp Lys
            500                 505                 510         
Tyr Trp Ser Gln Gln Ile Glu Glu Ser Thr Thr Val Val Thr Thr Gln
        515                 520                 525             
Ser Ala Gln Val Glu Gln Leu Asn Arg Ile Leu Leu His Leu Glu Ser
    530                 535                 540                 
Glu Leu Ala Gln Thr Gln Ala Glu Gly Gln His Gln Ala Gln Glu Tyr
545                 550                 555                 560 
Glu Thr Met Leu Asn Ile Lys Val Lys Leu Glu Ala Glu Ser Ala Thr
                565                 570                 575     
Cys His Arg Leu Leu Glu Asp Gly Lys Asn Phe Ser Leu Asp Asp Ala
            580                 585                 590         
Leu Asp Ser Ser Asn Ser Met Gln Thr Ile Gln Lys Thr Thr Thr Arg
        595                 600                 605             
Trp Ile Val Asp Gly Arg Val Val Ser Glu Thr Ser Asp Thr Lys Val
    610                 615                 620                 
Leu Arg His
625         


<210> 2768
<211> 382
<212> PRT
<213> Homo sapiens

<400> 2768
Met Tyr Pro Glu Lys Ile Lys Gly Thr Ser Cys Gly Lys Lys Gly Pro
 1               5                  10                  15      
Cys Phe Ser Ile Lys Ser Gln Gln Arg Thr Leu Ser Ser Ser Thr Asp
            20                  25                  30          
Gly Lys Gln Arg Glu His Gly Arg Gly Gly Ala Gln Thr His Trp Arg
        35                  40                  45              
Ser Gly Cys Gly Arg Cys Ser Asp Gly Ser Glu His Thr Val Ile Thr
    50                  55                  60                  
Gln Lys Thr Val Trp His Lys Glu Gly Lys Thr Ala Gly Glu Lys Gly
65                  70                  75                  80  
Ala Asp Gly Gly Asn Asp Ile His Val Asp Glu Asp Cys Asn Lys Asp
                85                  90                  95      
Glu Pro Glu Leu Glu Lys Gly Thr Pro Glu Glu Asn Asp Lys Lys Gly
            100                 105                 110         
Leu Tyr Leu Ala Ser Tyr Glu Ser Glu Ser Pro Glu Asn Gln Thr Glu
        115                 120                 125             
Lys Glu Arg Trp Lys Ala Leu Ser Leu Ser Pro Arg Gly Leu Gly Thr
    130                 135                 140                 
Ser Gly Ala Thr Ala Gly Ile Thr Val Arg Arg Glu Met Pro Ala Pro
145                 150                 155                 160 
Ala Pro Ser Pro Leu Ala Ala Thr Ala Ile Pro Pro Met Val Pro His
                165                 170                 175     
Pro Ala Leu Pro Thr Ser Leu Ser Leu Gln Pro Gln Ala Met Ser Gly
            180                 185                 190         
Pro Ser Ala Val Glu Ser His Ser Val Ser Asp Leu Ala Val Leu Asp
        195                 200                 205             
Leu Gly Pro Ile Trp Gly Thr Gly Arg Asp Arg Ala Thr Ser Ser Arg
    210                 215                 220                 
Cys Leu Ser Gln Leu Arg Asp Ser Ala Trp Asp Gly Lys Gln Cys Gly
225                 230                 235                 240 
Glu Val Gly Ala Gly Leu Pro Gln Gly Leu Gly Arg Ala Leu Gly Ala
                245                 250                 255     
Lys Pro Gln Glu Phe Gly Gly Phe Gln Glu Leu Val Arg Ala Ile Val
            260                 265                 270         
Ser Pro Ser Ser Leu Pro Gly Thr Leu Ser Pro Trp His Pro Leu Gly
        275                 280                 285             
Asn Met Arg Lys Ala Pro Ser Arg Val Arg Ala Ala Ala Ser Gly Ala
    290                 295                 300                 
Gly Pro Ile Ser Gln Lys Pro Phe Leu Ala Ala Ala Pro Ser Gly Pro
305                 310                 315                 320 
Ala Gln Asp Gly Tyr Gln Glu Asp Gly Gln Val Pro Glu Pro Pro Val
                325                 330                 335     
Ser Pro Gly Val Ser Gly Gly Pro Cys Thr Val Ser Phe Met Leu Lys
            340                 345                 350         
Thr Lys Ser Ala Thr Ala Gln Leu Pro Ser Cys Thr Cys Pro Gly Pro
        355                 360                 365             
Leu Gln Ala Leu Leu Gly Lys Ala Met Pro His Thr Gln Pro
    370                 375                 380         


<210> 2769
<211> 141
<212> PRT
<213> Homo sapiens

<400> 2769
Met Cys Lys Thr Pro His Leu Asp Gln Gly Ser Arg Arg Lys Asp Phe
 1               5                  10                  15      
Ala Lys Glu Lys Gln Gly Pro Arg Leu Gly Pro Gly Val Leu Glu Gly
            20                  25                  30          
Arg Lys Ser Pro Ser Thr Thr Thr Ile Gly Pro Gly Glu Ser Leu Cys
        35                  40                  45              
Ser Pro Gly Leu Glu Gly Thr Lys Lys Gly Ser Leu Gln His Glu Val
    50                  55                  60                  
Pro Gly Val Ala Cys Ala Met His Ala Lys Trp His Leu Ser Phe Asn
65                  70                  75                  80  
Ala Glu Ala Gly Phe Ile Tyr Gln Ala Cys Ala Leu His Cys Asp Leu
                85                  90                  95      
Leu Arg Asp Arg Ala Leu His Ser Arg Tyr Ser Tyr His Leu Val Phe
            100                 105                 110         
Ala Lys Ser Leu Lys Phe Leu Gln Gln Leu Phe Val Pro Gly Glu Thr
        115                 120                 125             
Phe Thr Ser Tyr Cys Ser Asn Lys Leu Ile Ile Ala Asn
    130                 135                 140     


<210> 2770
<211> 700
<212> PRT
<213> Homo sapiens

<400> 2770
Met Gln Ala Asn His Gly Leu Val Ile Val Arg Gly Gln Arg Lys Gln
 1               5                  10                  15      
Pro Leu Ala Val Trp Ser Leu His Val Thr Ala Val Leu Ser Ser Val
            20                  25                  30          
Met Val Thr His Val Asp Phe Ile Leu Asn Phe Leu Pro His Asn Gln
        35                  40                  45              
Val Ile Pro Thr Ile Thr Leu Ser Thr Glu Gln Glu Phe Gly Gly Ser
    50                  55                  60                  
Gln Leu Ser Thr Thr Val Leu Asn Leu Thr His Met Pro Ile Lys Gln
65                  70                  75                  80  
Glu Ala Pro Ser Thr Pro Tyr Thr Ile Pro Pro Arg Gln Val Leu Glu
                85                  90                  95      
Asp Arg Ala Leu Gln Trp Leu Leu Phe His Ser Val Ser Pro Pro Arg
            100                 105                 110         
Ser Val His Ser Glu Asn Thr Phe Leu Ile Ala Tyr Leu Phe Leu Lys
        115                 120                 125             
Thr Asn Pro Ser Thr Cys Ser Asn Gly Leu Ser Lys Glu Lys Ala Ala
    130                 135                 140                 
Ile His Ser His Arg Leu Leu Lys Thr Asp Cys Val Lys Asp Ser Asn
145                 150                 155                 160 
Gly Gln Val Ser Lys Thr Leu Gln Arg Tyr Phe Val Arg Thr Met Leu
                165                 170                 175     
Cys Ser Gln Leu Gly Phe Cys Ser Met Glu Thr Val Lys Cys Leu Leu
            180                 185                 190         
Ser Trp Gly Trp Leu Gly Leu Arg Lys Ala Val Arg Asp Glu Ser Cys
        195                 200                 205             
Ala Gly Arg Glu Leu Cys Trp Arg Pro Tyr Ile Ser Lys Asn Glu Glu
    210                 215                 220                 
Gln Val Lys Val Ser Gly Arg Val Leu His Tyr Ile Val Ser Glu His
225                 230                 235                 240 
Val Glu His Asn Glu Gly Phe Glu Arg Ala Glu Arg Glu Lys Ser Leu
                245                 250                 255     
Thr Asn Gln Ile Leu Glu His Val Gln Gly Gly Glu Ser Phe Cys Phe
            260                 265                 270         
Leu Trp Ser Tyr Leu Ala Gly Met Thr Glu Glu Val Ser Val Leu Val
        275                 280                 285             
Leu Leu Leu Asp Pro Gly Pro Ile Ile Ala Arg Leu Ser His Cys Leu
    290                 295                 300                 
Gln Thr Glu Ala Ser Gln Ile Cys Leu Val Ser Ala Val Thr Phe Ser
305                 310                 315                 320 
Val Ile Ile His Val Ile Pro His Ile Ala Pro Glu Phe Pro Glu Phe
                325                 330                 335     
Ser Glu Arg Ala Ser Glu Gln Asp Val Arg Lys Asn Ser Ser Ala Cys
            340                 345                 350         
Lys Leu Ser Leu Met Leu Ala Leu Thr Ala Pro Val Gly Phe Tyr Val
        355                 360                 365             
Thr Thr Ser Ser Leu Leu Trp Glu Leu Lys Ile Phe Tyr Val Phe Phe
    370                 375                 380                 
Glu Met Asp Pro Asn Ser Leu Gln Ile His Cys Glu Val Asp Ile Asp
385                 390                 395                 400 
Asp Glu Thr Gly Gly Pro Thr Leu Leu Leu Thr Asn Tyr His Tyr Arg
                405                 410                 415     
Pro Pro Lys Arg Lys Glu Glu Glu Arg Glu Ser Pro Asp Lys Ala Phe
            420                 425                 430         
Pro Val Phe Lys Lys Val Lys Gly Ser Leu Asn His Ser Leu Val Ala
        435                 440                 445             
Glu Ala Ala Lys Arg Leu Gln Pro Thr Gln Glu Arg His Ile His Tyr
    450                 455                 460                 
Asn Gln Met Asp Cys Gly Gly Ser Asn Glu Lys Pro Val Pro Gln Val
465                 470                 475                 480 
Leu Phe Leu Ala Gly Glu Ala Pro Glu Ala Cys Glu Ser Lys Lys Gly
                485                 490                 495     
Gly Tyr Pro Ser Asp Arg Val Ala Arg Phe Trp Gly Thr Arg Glu Arg
            500                 505                 510         
Gln Val Arg Pro Arg Pro Phe Lys Thr Leu Glu Ser Val Asp Val Ala
        515                 520                 525             
Asn Gln Cys Leu Ala Gly Pro Lys Asn Pro Thr Thr Ser Gly Ser Arg
    530                 535                 540                 
Ala Arg Ala Leu Met Ser Gly Ala Pro Gln Met Ser Gly Ala Pro Gln
545                 550                 555                 560 
Ser Asn Gly Leu Gly Ser Asp Ser Pro Ile Val Pro Arg Ser Phe Lys
                565                 570                 575     
Val Leu Gln Glu Pro Gln Met Leu Ser Leu Pro His Ser Ser Pro Thr
            580                 585                 590         
His Leu Leu Ala Ile His Val Val Thr Gly Gly Pro Thr Pro Gln Ser
        595                 600                 605             
Leu His Leu Lys Gly Phe Pro Asp Ile Asp Asp Leu Leu Leu Ser Asn
    610                 615                 620                 
Leu Val Ile Ala Leu Leu Pro Ser Cys Val Ser Gln Arg Gly Cys Pro
625                 630                 635                 640 
Cys Ala Arg Gln Ala Pro Val Cys Ala Pro Gly Pro Val Ser Trp Pro
                645                 650                 655     
Pro Gln Ile Leu Val Tyr Val Gln Val Thr Arg Ile Ser Gly Ser Gln
            660                 665                 670         
Ala Ser Ser Gly Ala Cys Cys Arg Leu Asp Asn Leu Val Asp Lys Thr
        675                 680                 685             
Gly Ser Lys Phe Arg Ser Leu Ile Phe Met Leu Val
    690                 695                 700 


<210> 2771
<211> 417
<212> PRT
<213> Homo sapiens

<400> 2771
Met Gln Leu Asn Val Glu Arg Asp Phe Leu Asp Met Val Pro Ser Tyr
 1               5                  10                  15      
Thr Trp Gln Met Met Ser Pro Ala Ser Pro Ser Thr Ala Tyr Thr Gly
            20                  25                  30          
Gly Gly Gly Gly Ala Ser Lys Val Asp Ala Arg Leu Thr Ser Pro Ala
        35                  40                  45              
Gln Glu Ala Leu Gln Pro Pro Gly Ser Pro Glu His Val Val Gly Gln
    50                  55                  60                  
Gly Leu Gly Leu Phe Leu Val Asn Ser Ala Ser Glu Ile Leu Leu Leu
65                  70                  75                  80  
Leu Lys Ser Ile Ser Ala Tyr Ile Ile Arg Ala Ser Leu Thr Tyr Ala
                85                  90                  95      
Val Leu Phe Trp Thr Ile Lys Cys Gln Trp Val Leu Ala Lys Ala Leu
            100                 105                 110         
Tyr Thr Gln Asn Asn Glu Pro Arg Ala Arg Arg Lys Leu Gln Ser Arg
        115                 120                 125             
Leu Phe Thr Gly Lys Gly Asp Ala Ala Gln Asp Leu Pro Leu Asn Leu
    130                 135                 140                 
Ser Gly Ser Val Ser Phe Met Gly Leu Arg Gly Asp Gly Gly Glu Glu
145                 150                 155                 160 
Lys Asp Phe Thr Arg Leu Ser Ala Asp Thr Leu Val Leu Glu Ala Leu
                165                 170                 175     
Glu Trp Asp Ser Trp Val Ala Pro Arg Lys Thr Pro Gln Pro Leu Glu
            180                 185                 190         
Leu Gln Gly Ser Ser Thr Pro Glu Lys Gly Asp Ile Gly Gly Asn Cys
        195                 200                 205             
Lys Arg Val Ser Pro Thr Gly Ser His Pro Leu Gln Val Cys Pro Leu
    210                 215                 220                 
Lys Asp Ala Thr Ser Lys Glu Met Gly Pro Ala Leu Cys Trp Gly Ala
225                 230                 235                 240 
Phe Lys Glu Glu Trp Leu His Asp Gly Asn Glu Arg His Arg Leu Lys
                245                 250                 255     
Asp Ser Leu Arg Glu Ser Pro Arg Ala Ala Glu Glu Gln Gly Ser Tyr
            260                 265                 270         
Tyr Tyr Thr Ser His Ile Phe Ile Ile Leu Asp Val Phe Phe Arg Asn
        275                 280                 285             
Cys Met Ser Val Tyr Met His Ile Thr Arg Tyr Asn Ala Asn Thr Leu
    290                 295                 300                 
Lys Ile Leu Asn Thr Gln Ala Leu Glu Asn Cys Asn Pro Ser Lys Cys
305                 310                 315                 320 
Gly Gly Cys Glu Ala Phe Lys Lys Leu Gly Gln Glu Gln Gly Leu Lys
                325                 330                 335     
Glu Glu His Gln Phe Thr Gly Glu Ala Lys Pro Lys Pro Lys Lys Thr
            340                 345                 350         
Pro Gln Gln Cys Ile Ala Glu Lys Thr Tyr Phe Pro Thr Trp Met Ser
        355                 360                 365             
Cys Arg Arg Pro Gln Leu Asn Gly Pro Lys Ser Ala Leu Thr Asp Ser
    370                 375                 380                 
Ser Leu Val Asn His Leu Leu Glu Pro Pro Leu Asp Pro Pro Ala Thr
385                 390                 395                 400 
Ile Leu Leu Ile Leu Val Asn Asn Val Pro His Leu Pro Tyr Arg Phe
                405                 410                 415     
Ser
    


<210> 2772
<211> 252
<212> PRT
<213> Homo sapiens

<400> 2772
Met Val Ser Trp Ile Ile Ser Arg Leu Val Val Leu Ile Phe Gly Thr
 1               5                  10                  15      
Leu Tyr Pro Ala Tyr Ser Ser Tyr Lys Ala Val Lys Thr Lys Asn Val
            20                  25                  30          
Lys Glu Tyr Val Lys Trp Met Met Tyr Trp Ile Val Phe Ala Phe Phe
        35                  40                  45              
Thr Thr Ala Glu Thr Leu Thr Asp Ile Val Leu Ser Trp Phe Pro Phe
    50                  55                  60                  
Tyr Phe Glu Leu Lys Ile Ala Phe Val Ile Trp Leu Leu Ser Pro Tyr
65                  70                  75                  80  
Thr Lys Gly Ser Ser Val Leu Tyr Arg Lys Phe Val His Pro Thr Leu
                85                  90                  95      
Ser Asn Lys Glu Lys Glu Ile Asp Glu Tyr Ile Thr Gln Ala Arg Asp
            100                 105                 110         
Lys Ser Tyr Glu Thr Met Met Arg Val Gly Lys Arg Gly Leu Asn Leu
        115                 120                 125             
Ala Ala Asn Ala Ala Val Thr Ala Ala Ala Lys Gly Val Leu Ser Glu
    130                 135                 140                 
Lys Leu Arg Ser Phe Ser Met Gln Asp Leu Thr Leu Ile Arg Asp Glu
145                 150                 155                 160 
Asp Ala Leu Pro Leu Gln Arg Pro Asp Gly Arg Leu Arg Pro Ser Pro
                165                 170                 175     
Gly Ser Leu Leu Asp Thr Ile Glu Asp Leu Gly Asp Asp Pro Ala Leu
            180                 185                 190         
Ser Leu Arg Ser Ser Thr Asn Pro Ala Asp Ser Arg Thr Glu Ala Ser
        195                 200                 205             
Glu Asp Asp Met Gly Asp Lys Ala Pro Lys Arg Ala Lys Pro Ile Lys
    210                 215                 220                 
Lys Ala Pro Lys Ala Glu Pro Leu Ala Ser Lys Thr Leu Lys Thr Arg
225                 230                 235                 240 
Pro Lys Lys Lys Thr Ser Gly Gly Gly Asp Ser Ala
                245                 250         


<210> 2773
<211> 453
<212> PRT
<213> Homo sapiens

<400> 2773
Met Thr His Ser Leu Pro Asn Pro Ser Pro Trp Leu Asn Phe Pro Asp
 1               5                  10                  15      
Pro Gly Ser Pro Gly Ser Pro Phe Gln His Asn Pro His Pro Ser Gln
            20                  25                  30          
Leu Thr Tyr Pro His Pro Leu Met Asn Pro Leu Pro Phe Lys Asp Ser
        35                  40                  45              
Ser Ser Pro Phe Leu Leu Gln Asp Tyr Ser Trp Leu Leu Ser Tyr Ser
    50                  55                  60                  
Phe Phe Arg Pro Lys Ala Cys Ala Val Ser Glu Pro Asn Ser Gly Pro
65                  70                  75                  80  
Val Ala Arg Gln Asn Leu Ser Gln Ser Leu Cys Thr Ser His Arg Ile
                85                  90                  95      
Tyr Val Cys Glu Ala Thr Gly Leu Ile Val Ala Cys Tyr His Gly Phe
            100                 105                 110         
Val Asp Thr Val Val Ala Leu Ala Glu Cys Pro His Val Asp Val Asn
        115                 120                 125             
Trp Gln Asp Ser Glu Gly Asn Thr Ala Leu Ile Thr Ala Ala Gln Ala
    130                 135                 140                 
Val Lys Asp Glu Gly Glu Gln Cys Gly Val Asn Glu Ser Lys Lys His
145                 150                 155                 160 
Gln Arg Leu Ala Glu Gly Leu Ala Gly Thr Ser Thr Phe Cys Gly Ser
                165                 170                 175     
Gly Asn Gln Tyr Thr Cys Thr Leu Leu Phe Thr Gly His Ala Ile Ile
            180                 185                 190         
Thr Asn Tyr Leu Leu Asn Tyr Phe Pro Gly Leu Asp Leu Glu Arg Arg
        195                 200                 205             
Asn Ala Phe Gly Phe Thr Ala Leu Met Lys Ala Ala Met Gln Gly Arg
    210                 215                 220                 
Thr Asp Cys Ile Arg Ala Leu Met Leu Ala Glu Leu Arg Ser Leu Pro
225                 230                 235                 240 
Gly Lys Leu Arg Gly Gly Cys Pro Arg Glu Gly Pro Pro Pro Trp Asp
                245                 250                 255     
Val Ala Ala Gly Val Gly His Leu His Gly Pro Arg Gly Cys Arg Pro
            260                 265                 270         
Ser His Ala Glu Ala Ala Gly Ala Pro Leu Pro Gly Ala Val Leu Gly
        275                 280                 285             
Glu Arg Leu Thr Asp Cys Val Leu Ser Val Leu Thr Pro Arg Ser Val
    290                 295                 300                 
Arg Gly Pro Glu Asp Gly Gly Val Leu Asp His Met Val Arg Met Thr
305                 310                 315                 320 
Thr Ser Leu Tyr Ser Pro Ala Val Ala Ile Val Cys Gln Thr Val Cys
                325                 330                 335     
Pro Glu Ser Pro Pro Ser Val Gly Lys Arg Arg Leu Ala Val Gln Glu
            340                 345                 350         
Ile Leu Ala Ala Arg Ala Ala Arg Gly Pro Gln Ala Gln Glu Glu Asp
        355                 360                 365             
Glu Arg Leu Arg Arg Arg Ser Val Arg Pro Gly Val Val Val Pro Arg
    370                 375                 380                 
Val Arg Val Ser Lys Ala Pro Ala Pro Thr Phe Gln Pro Glu Arg Pro
385                 390                 395                 400 
Ala Arg Lys Gly Ser Thr Lys Asp Ser Gly His Leu Gln Ile Pro Lys
                405                 410                 415     
Trp Arg Tyr Lys Glu Ala Lys Glu Glu Lys Arg Lys Ala Glu Glu Ala
            420                 425                 430         
Glu Lys Lys Arg Gln Ala Glu Ala Gln Lys Glu Arg Arg Thr Ala Pro
        435                 440                 445             
Trp Lys Lys Arg Thr
    450             


<210> 2774
<211> 512
<212> PRT
<213> Homo sapiens

<400> 2774
Met Lys Thr Ile Gln Ala Ala Arg Ala Gln Arg Asn Gly Gln Cys Pro
 1               5                  10                  15      
Pro Trp Thr Val Pro Gly Gln Pro Gln Arg Glu Ala Gly Glu Lys Val
            20                  25                  30          
Thr Leu Pro Met Arg Cys Gln Arg Thr Ser Pro Ser Trp Met Cys Trp
        35                  40                  45              
Arg Pro Thr Ala Pro Gln His Ser Ser Ser Thr Ser Pro Cys Cys Ser
    50                  55                  60                  
Ser Ala Pro Leu Thr Pro Lys Pro Gln Ser Ser Pro Ser Ser Thr Cys
65                  70                  75                  80  
Leu Gly Pro Gln Glu Glu Leu Pro Val Leu Ala His Ser Thr Ala Ser
                85                  90                  95      
Cys Glu Val Phe Ser Leu Phe Gln Leu Gln Ala Tyr Thr Arg Thr Ala
            100                 105                 110         
Leu His Ile Pro Phe Leu Leu Asn Val Pro Gln Ser Arg Phe Ser Ser
        115                 120                 125             
Phe Pro Ser Lys Gly Met Thr Ser His Ala Asn Pro Pro Arg Asp Gly
    130                 135                 140                 
Leu Trp Ser Thr Cys Gly Ser Pro Trp Thr Thr Gly Pro Gln Ser Arg
145                 150                 155                 160 
Gly Ser Ala Ile Arg Gly Gly Leu Ala Ala Ala Ser Leu Ala Ile Val
                165                 170                 175     
Ser Val Ser Ser Arg Ile Arg Phe Leu Ala Arg Tyr Leu Asp Gly Leu
            180                 185                 190         
Gln Ala Met Glu Asn Lys Glu Phe Glu Val Pro Glu Ser Leu Thr Leu
        195                 200                 205             
Gly Thr Gly Arg Ala Arg Arg Glu Glu Val Ala Val Ala Arg Leu Asp
    210                 215                 220                 
Ala Val Val Val Tyr Ala Ser Leu Gln Val Gln Arg Pro Val Met Val
225                 230                 235                 240 
Asp Gly Gln Gly Trp His Pro Trp Ala Gly Ala Asp Thr Lys Ile Gln
                245                 250                 255     
Leu Pro Pro Arg Gln Phe Asp Asn Gln Gly Gln Val Asp Thr Arg Lys
            260                 265                 270         
Ala Thr Ala Ser Val Arg Gly Cys Gln Glu Asn Pro Glu Ile Gln Glu
        275                 280                 285             
Arg Leu Ser Ile Ala Gly Thr Ile Lys Asn Gln His Gln Asn Gln Gly
    290                 295                 300                 
Ala His Met Thr Arg Leu Phe Leu Tyr Ser Ile Glu Lys Arg Gly Ser
305                 310                 315                 320 
Phe Leu Ile Lys Leu Leu Pro Arg Leu Asn Glu Cys Val Ser Glu Ile
                325                 330                 335     
Leu Lys Val Asn Ser Ala Arg Ser Lys Asp Ile Gln Thr Lys Gly Glu
            340                 345                 350         
Arg Gln Ser Pro Lys Pro Glu Cys Ser Pro Leu Ala Ser Asp Pro Arg
        355                 360                 365             
Asp Asp Ala Gly Ser Gly Gly Gly Ser Arg Phe Leu Ile Ala Gln Leu
    370                 375                 380                 
Ile Cys Gly Lys Phe Leu Cys His Ala Gly Thr Phe Ser Ala Thr Glu
385                 390                 395                 400 
Ser Gly Pro Asn Ser Gln Val Gly Leu Arg Ala Ser Leu Ala Ala Leu
                405                 410                 415     
Leu Ala Val Glu Leu Val Ala Ala His Pro Val Leu Gly Tyr Gln Leu
            420                 425                 430         
Ala Val His Cys Glu Ser Asn Thr His Met Ser Pro Trp Pro Gln Ala
        435                 440                 445             
Leu Arg His Leu Val Asn Leu Ser Val Pro Thr Phe Leu Lys Gly Leu
    450                 455                 460                 
Leu Leu Gln Ala Asn Thr Leu Leu Ala His Thr Val Arg Arg Glu Pro
465                 470                 475                 480 
Trp Gly Cys Gly His Pro Ala Glu Thr Ala Ala His Arg Asn Pro Leu
                485                 490                 495     
Ala Thr Ser Ala Ser Ile Ser Val His Asn Ile Phe Arg Phe Leu Ser
            500                 505                 510         


<210> 2775
<211> 104
<212> PRT
<213> Homo sapiens

<400> 2775
Met Lys Ser Glu Gly Arg Cys Gly Asp Ser Ser Gly Lys Ser Val Glu
 1               5                  10                  15      
Lys Val Lys Ile Leu Leu Val Gly Thr Phe Arg Ala Gly Pro Thr Ala
            20                  25                  30          
Gly Gly Pro Ser Phe Met Lys Val Gln Tyr Leu Ser Phe Ala Val Asp
        35                  40                  45              
Leu Asp Phe Lys Asn Asp Ser Leu Thr Thr Arg Val Cys Asp Ser Leu
    50                  55                  60                  
Lys Leu Met Gln Ser Val Asp Val Leu His Ser Glu Lys Gly Ser Leu
65                  70                  75                  80  
Leu Lys Asn Thr Glu Val His Phe Pro Leu Lys Ala Leu Leu Asn Ser
                85                  90                  95      
Gln Thr His Asp Asp Leu Ser Leu
            100                 


<210> 2776
<211> 316
<212> PRT
<213> Homo sapiens

<400> 2776
Met Ala Ser Leu Gly Leu His Met Ser Ala Gly Gln Glu Trp Pro Pro
 1               5                  10                  15      
His Phe Glu Asn Val Ser His Arg Cys Gly Thr His Cys Glu Glu Glu
            20                  25                  30          
Gly Pro Thr Val Gly Pro Ser Arg Lys Glu Ala Asp Glu Leu Arg Ile
        35                  40                  45              
Gly His Ser Gln Lys Val Asp Thr Pro Trp Ala Pro Ser Ile Pro Ala
    50                  55                  60                  
Gly Ala Phe Leu Asn Gln Ala Thr Gly Ile Thr Val Asn Arg Thr His
65                  70                  75                  80  
Gly Gly Ser Ala Ala Cys Arg Gly Leu Val Ser Val Arg Ser Asp Tyr
                85                  90                  95      
Ile Tyr Ala Ile Gly Tyr Leu Gln Leu Leu Pro Ser Phe Ile Pro Gln
            100                 105                 110         
Pro Tyr Ser Asp Val Leu Ser Asp Met Val Pro Pro Lys Glu Ala Gln
        115                 120                 125             
Glu Asp Ile Leu Glu Arg Ser Asn Arg Gly Pro Ser Arg Pro Glu Arg
    130                 135                 140                 
Cys Ala Glu Glu Ala Ile Cys Glu Gln Lys Ala Asp Thr Gln Asn Ala
145                 150                 155                 160 
Arg Cys Ser Met Gly Asn Thr Ser Arg Asp Thr His Arg Gly Asn Leu
                165                 170                 175     
Asn Glu Asn Phe Arg Thr Met Leu Thr Pro Ala Thr Tyr Pro Asp Val
            180                 185                 190         
Gln Lys Ser Val Gln Thr Gln Lys Gln Ile Asn Leu Val Arg Ile Ser
        195                 200                 205             
Leu Leu Gln Gly Lys Ile Ser Thr His Arg Cys Thr Val Ser Tyr Asp
    210                 215                 220                 
Glu Gly Ser His Ala Thr Ile Trp Gln Thr Glu Asn Arg Arg Met Ile
225                 230                 235                 240 
Arg Ala Lys Cys Trp Glu Gly Lys Gln His Pro Thr Thr Thr Lys Glu
                245                 250                 255     
Gly Arg Lys Ser Glu Arg His Asp Thr Ala Arg Glu Lys Pro Gln Arg
            260                 265                 270         
Gln Asp Ile Pro Thr Pro Gly Asp Thr Arg Gln Asp Arg Arg Glu Arg
        275                 280                 285             
Arg Glu Asp Arg Gln Gln Gly Gly Ser Glu Arg Glu Pro Ala His Gly
    290                 295                 300                 
Gly Ala Ala Ala Asp Pro Leu Phe Leu Val Ser Gln
305                 310                 315     


<210> 2777
<211> 74
<212> PRT
<213> Homo sapiens

<400> 2777
Met Gly Pro Ile Ser Gly Ile Cys Ala Ala Gly Pro Ser Ser Ala Ala
 1               5                  10                  15      
Ser Gly Gly Gly Arg Ser Gly Arg Gln Gly Trp Ala Arg Arg Pro Ala
            20                  25                  30          
Ser Leu Glu Ala Ala Glu Ala Gly Glu Gly Ala Ala Lys Val Ala Val
        35                  40                  45              
Arg Ala Pro Gly Arg Ala Arg Ala Gly Trp Thr Pro Gly Pro Ala Ala
    50                  55                  60                  
Pro Arg Ala Pro Glu Ser Tyr Glu Cys Arg
65                  70                  


<210> 2778
<211> 136
<212> PRT
<213> Homo sapiens

<400> 2778
Met Lys Leu Lys Ile Gly Asp Arg Val Glu Asp Asn Ser Ile His Arg
 1               5                  10                  15      
Lys Asp Gln Glu Ile Lys Lys Ala Leu Met Leu Leu Val Ala Thr Cys
            20                  25                  30          
Asn Leu Ala Ala Leu Glu Gly Glu Ala Glu Arg Glu Arg Met Thr Val
        35                  40                  45              
Gly Leu Val Leu Leu Lys Trp Ser Leu Trp Pro His Cys Glu Lys Cys
    50                  55                  60                  
Thr Asp Gly Val Leu Val Asp Val Arg Ala Asn Gly Arg Gly Tyr Lys
65                  70                  75                  80  
Leu Trp Val Lys Asp Gly Cys Phe Asp Lys Ser Gly Gly Cys Gly Glu
                85                  90                  95      
Lys Ile Leu Gly Asn Val Glu Tyr Ser Pro Arg Glu Ser Pro Gln Gly
            100                 105                 110         
Glu His Gln Asp Phe Val Val Asn Leu Glu Leu His Ile Leu Asp Gly
        115                 120                 125             
Leu Leu Glu Asp Ile Ile Asp Pro
    130                 135     


<210> 2779
<211> 279
<212> PRT
<213> Homo sapiens

<400> 2779
Met His Val Ile Phe Tyr Ile Trp Asn Ser Val Lys Ala Phe Leu Ile
 1               5                  10                  15      
Asp Ile Leu Leu Leu Lys Cys Ser Gly Gly Ser Ser Phe Leu Ser Arg
            20                  25                  30          
Pro Val Leu Trp Cys Val Leu Arg Ile Ser Ala Gly Asp Ser Glu Lys
        35                  40                  45              
Ser Pro Phe Ser Asn Pro Ser Lys Lys Leu Leu Thr Glu Ser Arg Cys
    50                  55                  60                  
Glu Trp Ala Ile Thr Ala Ser Trp Ser Tyr Gln Glu Pro Trp Ser Gly
65                  70                  75                  80  
Ile Pro Ile Leu Asn Gly Asp Ser Ala Ala Tyr Gln Arg Pro Thr Leu
                85                  90                  95      
Cys Glu Leu Leu Glu Ser Phe Gln Leu His Lys Asn Cys Lys Lys Asn
            100                 105                 110         
Lys Gln Thr Asn Lys Lys Pro Leu Gly Leu Val His Thr Ile Gly Lys
        115                 120                 125             
Ala Arg Ser Ile Arg Leu Gln Arg Asp Ser Ser Gln Ser Tyr Leu Leu
    130                 135                 140                 
Lys Thr Phe Leu Leu Val Gly Arg Lys Lys Gly Tyr Ser Thr Ile Lys
145                 150                 155                 160 
Arg Gln Ile Gln Lys Lys Asp Phe Ser His Val Ile Glu Asn Pro Tyr
                165                 170                 175     
Ser Lys Asp Glu Asn Val Ile Ile Lys Arg Leu Tyr Asn Cys Arg Thr
            180                 185                 190         
Ile Ala Ile Ser Leu Phe Ser Ala Ser Asp Leu Leu Asn Trp Lys Ser
        195                 200                 205             
Ser Asn Pro Pro Phe Arg Asp Asp Pro Gln Lys Ile Thr Asn Leu Phe
    210                 215                 220                 
Lys Ala Ile Phe Val Tyr Gly Glu Pro Thr His Pro Leu Arg Ser Thr
225                 230                 235                 240 
Phe Asn Leu Lys Leu Leu Leu Ala Leu Pro Val Glu His Ile Leu Thr
                245                 250                 255     
Phe Phe Arg Thr Lys Phe Val Trp Asp Thr Pro Leu Ser Phe Ala Phe
            260                 265                 270         
Ile Lys Phe Ile Ile Val Leu
        275                 


<210> 2780
<211> 346
<212> PRT
<213> Homo sapiens

<400> 2780
Met Glu Ser Leu Gln Gly Glu Lys Glu Gln Glu Leu Gln Arg Lys Pro
 1               5                  10                  15      
Trp Glu Pro Lys Asp Gly Gly Val Lys Glu His Ser Gly Ala Gly Cys
            20                  25                  30          
Gly Trp Arg Gly Leu His Ser Pro Glu Arg Ile Ser Asn Cys Ser Ser
        35                  40                  45              
Ser Leu Phe Thr Ala Val Lys Ala Phe Gly Ile Ser Ile Thr Arg Lys
    50                  55                  60                  
Ala Lys Leu Thr Gly Glu Ser Tyr Asn Asp Leu Leu Lys Gly Val Glu
65                  70                  75                  80  
Cys Tyr Arg Phe Arg Lys Gly Asp Ala Cys Glu Gly Lys Asp Arg Glu
                85                  90                  95      
Gln Glu Pro Gln Leu Gln Pro Phe His Ala Leu Ala Val Ser Arg Asp
            100                 105                 110         
Val Pro Ser Gln Ala Tyr Pro Leu Leu Ile Pro Lys Ser Glu Lys Glu
        115                 120                 125             
Ile Arg Val Pro Val Ser Ser Arg Glu Asp Glu Leu Gly Arg Arg Ser
    130                 135                 140                 
Asp Val His Leu Leu Tyr Gly Leu Ser Gly Lys Ala Ser Leu Phe Ser
145                 150                 155                 160 
Pro Cys Leu Thr Thr Ala Phe Ser Ser Ser Asp Val Pro Arg Val Pro
                165                 170                 175     
Phe Phe Gln Ser Ser Pro Lys Tyr Phe Phe Gln Ser Thr Pro Asn Arg
            180                 185                 190         
Arg Arg Glu Gly Thr Glu Ala Gly Arg Cys Ala Gly Ala Gln Glu Val
        195                 200                 205             
Leu Thr Lys Pro Leu Gln Arg Asn Gly Ser Met Met Ser Phe Glu Asn
    210                 215                 220                 
Val Lys Glu Lys Ser Arg Glu Gly Gly Pro His Ala His Thr Pro Glu
225                 230                 235                 240 
Glu Glu Leu Cys Phe Val Val Thr His Tyr Pro Gln Val Gln Thr Thr
                245                 250                 255     
Leu Asn Leu Phe Phe His Ile Phe Lys Val Leu Thr Gln Pro Leu Ser
            260                 265                 270         
Leu Leu Trp Gly Cys Asp Gln Lys Pro Arg Thr Val Pro Thr Leu Gly
        275                 280                 285             
Asn Gly Ala Trp Asp Thr Cys Gln Gln His Ile Arg Thr Ser Ser Trp
    290                 295                 300                 
Thr Ala Asn Thr Leu Val Ile Gln Asn Gln His Ser Arg Glu Ser Thr
305                 310                 315                 320 
Val Ser Val Cys Leu Phe Met Leu Ile Arg Met Gln His Ile Leu Lys
                325                 330                 335     
Thr Asp Thr Leu Gln Gln Phe Arg Ile Cys
            340                 345     


<210> 2781
<211> 212
<212> PRT
<213> Homo sapiens

<400> 2781
Met Pro Lys Leu Ser Leu Thr Val Leu Ala Glu Val Lys His Asn Tyr
 1               5                  10                  15      
Asn Phe Met Asp Leu Pro Asp Ala Ser Thr Gln Pro His Leu Ala Pro
            20                  25                  30          
Pro Pro Pro Pro Pro Ser Pro Arg Pro Leu Gln Ser Pro Pro Pro Thr
        35                  40                  45              
Arg Arg Leu Phe Ser Arg Ala Asp Ala Ala Ser Arg Leu Leu Ala Phe
    50                  55                  60                  
Pro Leu Arg Thr Lys Leu Pro Ala Gly Ala Ser Ala Ser Asp Arg Gln
65                  70                  75                  80  
Arg Ala Gly Ala Trp Phe Leu Arg Arg Leu Pro Gly Gly Cys Arg Gly
                85                  90                  95      
Cys Arg Asp Ala Gly Gly Leu Asn Thr Arg Met Gly Gln Arg Arg Gly
            100                 105                 110         
Ser Gly Leu Leu Gly Gly Ser Gly Gly Asn Leu Gly Ser Arg Thr Ala
        115                 120                 125             
Leu Phe Ile Gly Phe Ser Gly Thr Gly Arg Arg Asp Gly Glu Cys Gly
    130                 135                 140                 
Arg Arg Ser Pro Leu Ala Asp Arg Ser Ser Cys Ser Gly Asp Pro Gln
145                 150                 155                 160 
Val Gly Lys Leu Gly Gln Asn Ala Glu Arg Ser Arg Leu Leu Arg Ala
                165                 170                 175     
Val Arg Cys Gln Gly Ser Thr Ala Glu Arg Arg Gly Leu Arg Glu Gly
            180                 185                 190         
Arg Gly Arg Arg Ala Lys Trp Val His Asp Met Asn Cys Lys Ile Gly
        195                 200                 205             
Asp Cys Val Met
    210         


<210> 2782
<211> 296
<212> PRT
<213> Homo sapiens

<400> 2782
Met Glu Asn Arg Val Thr Arg Arg Gln Lys Pro Ala Gly Leu Leu Gln
 1               5                  10                  15      
Glu Met Ser Ser Gly Asp Arg Gly Ser Phe Ala Ala Glu Arg Asp Ala
            20                  25                  30          
Arg Asp Gln Asp Pro Glu Ser Gln Asp Thr Asn Glu Thr Pro Lys Asn
        35                  40                  45              
Ser Ser Val Arg Phe Leu Leu Pro Ser His Arg Trp Ser Glu Leu Gln
    50                  55                  60                  
Cys Lys Thr Glu Ser Gln Ser Leu Ala Ala Gly Asp Arg Arg Gly Leu
65                  70                  75                  80  
Ser Val Leu Ser Gly Ala Gln Gly Leu Arg Trp Ala Ala Gly Ala Glu
                85                  90                  95      
Gly Ala Pro Gly Arg Ser Gln Glu Val Leu Gly Ser Ser Thr Asp Pro
            100                 105                 110         
Glu Met Leu Lys Ser Asn Phe Val Phe Leu Lys Phe Leu Gly Ile Val
        115                 120                 125             
Gly Leu Ser Ser Leu Val Ala Leu Pro Leu Ser Pro Pro Val Gly Asp
    130                 135                 140                 
Val Leu Pro Leu Val Pro Ser Ser His Ser Phe Gly Glu Ala Gln Gly
145                 150                 155                 160 
Arg Met Ala Cys Thr Gly Ile Pro Thr Leu Ala Thr Leu Gly Glu Thr
                165                 170                 175     
Ser Asp Val Trp Ala Pro Thr Val Asp Ser Leu Pro Asp Gly Cys Val
            180                 185                 190         
Ser Leu Arg Ala Val Lys Pro Thr Ser Val Lys Val Gly Ser Lys Ala
        195                 200                 205             
Leu Tyr Gly Asn Arg Ser Lys Asn Gln Pro Glu Gln Leu Gly Val Ser
    210                 215                 220                 
Phe Ser Ser Met Trp Arg Leu Ala Ala Pro Ser Val Leu Leu Gly Leu
225                 230                 235                 240 
Glu Gly Leu Tyr Thr Ala Pro His Ser Gly Ser Leu Val His Pro Ser
                245                 250                 255     
Ser Gly Glu Leu Gly Lys Ala Arg Lys Ser Gly Met Arg Pro Arg Ser
            260                 265                 270         
Val Ser Leu Ser Leu His Ala Ala Ala Asp Arg Lys Pro Gln Leu Pro
        275                 280                 285             
Ala Ala Ala Ala Ala Glu Cys Leu
    290                 295     


<210> 2783
<211> 93
<212> PRT
<213> Homo sapiens

<400> 2783
Met Asn Glu Phe Leu Thr Gln Glu Leu Ala Glu Asp Gly Tyr Ser Gly
 1               5                  10                  15      
Val Glu Met Arg Val Thr Pro Thr Arg Thr Glu Ile Ile Val Leu Ala
            20                  25                  30          
Thr Arg Thr Gln Asn Val Leu Gly Glu Lys Gly Arg Arg Ile Arg Glu
        35                  40                  45              
Leu Thr Ala Val Val Gln Lys Arg Phe Gly Ser Pro Gly Arg Val Ser
    50                  55                  60                  
Ala Leu Gln Thr Pro Arg Arg Ala Cys Cys Ala Glu Gly Leu Leu Trp
65                  70                  75                  80  
Cys Val Ala Val His His Gly Asn Trp Gly Gln Arg Leu
                85                  90              


<210> 2784
<211> 123
<212> PRT
<213> Homo sapiens

<400> 2784
Met Thr Thr Glu Pro Gln Lys Glu Arg Thr Thr Trp Ser Leu Ala Thr
 1               5                  10                  15      
Arg Ile Leu Phe Asp Met Cys Ser Gly Gly Ser Cys Cys Val Thr Phe
            20                  25                  30          
Pro Lys Ser Leu Arg Ile Ile Ala Val Lys Ala Gln Ala Val Arg Phe
        35                  40                  45              
Glu Ser Leu Pro Thr Gly Leu Gln Cys Glu Gly Leu Ile Leu Leu Ile
    50                  55                  60                  
Glu Gln Lys His Thr Val Pro Ala Thr Glu Ala Ser Asp Ala Glu Ala
65                  70                  75                  80  
Pro Cys Asn Ser Pro Leu Leu Leu Lys Gln Leu Leu Val Trp Ser Ser
                85                  90                  95      
Val Val Trp Ser Glu Lys Thr Asp Ile Phe Leu Ser Ile Cys Asp Phe
            100                 105                 110         
Asn Val Phe Ala Ser Ser Ser Ser Ala Ala Pro
        115                 120             


<210> 2785
<211> 175
<212> PRT
<213> Homo sapiens

<400> 2785
Met Glu Arg Lys Lys Glu Arg Lys Glu Leu Ala Leu Met Asp Gln Gln
 1               5                  10                  15      
Gly Lys Glu Lys Gly Ala Gly Lys Ala Val Val His Val Gly Ile His
            20                  25                  30          
Lys Tyr Gly Pro Ser Leu Lys Glu Thr Gly Thr Gln His Pro Asp Ala
        35                  40                  45              
Lys Lys Glu Ala Met Thr Val Thr Leu Leu Glu Arg Val Gln Leu Trp
    50                  55                  60                  
Leu Met Gly Arg Trp Lys Gly Leu Leu Ser Cys Tyr Thr Asp Val Thr
65                  70                  75                  80  
Glu Asn Arg Pro Ser Leu Val Leu Gly Glu Leu Pro Val Gly Trp Cys
                85                  90                  95      
Tyr Thr Leu Glu Leu Ala Ala Lys Ser Ala Asp Trp Cys Cys Ala Ser
            100                 105                 110         
Glu Leu Ala Ala Lys His Leu Glu Thr Ser Thr Val Ser Gly Trp Arg
        115                 120                 125             
Gln Asn Pro Lys Pro His Lys Gly Met Lys Phe Pro Leu Thr Arg Cys
    130                 135                 140                 
Glu Glu Tyr Pro Asn Arg Leu Leu Leu Leu Pro Ser Ala Ala Ala Ile
145                 150                 155                 160 
Glu Asn Tyr Thr Lys Pro Ser Phe Cys His Lys Thr Ser Lys Ile
                165                 170                 175 


<210> 2786
<211> 298
<212> PRT
<213> Homo sapiens

<400> 2786
Met Ser Val Asp Ile Asn Thr Lys Glu Pro Thr Ser Leu Glu Ser Lys
 1               5                  10                  15      
Ser Asn Leu Gly Lys Val Gly Glu Arg Ala Ile Asp Lys Met Asp Phe
            20                  25                  30          
Leu Glu Ala Lys Glu Asn Glu Arg Asp Met Ile Ser Gln Val Arg Glu
        35                  40                  45              
Met Ser Gln Arg Thr Glu Asp Lys Ile Phe Glu Leu Ser Gln Ala Lys
    50                  55                  60                  
His Gln Ala Gly Ser Asn Arg Asn Met Asn Val Lys Asp Arg Ile Val
65                  70                  75                  80  
Lys Leu Val Leu Met Val Asn Gly His Glu Glu Lys Leu Arg Ser Leu
                85                  90                  95      
Glu Arg Pro Thr Phe Leu Ala Pro Ala Glu Ser Leu Ile Ile Tyr Ile
            100                 105                 110         
Gly Tyr Ala His Arg Ala Thr Ser Ser Asp Leu Ser Glu Arg Ser Pro
        115                 120                 125             
Glu Pro Thr Cys Glu Met Thr Glu Ile Gly Lys Ser Gln Asp Asn Thr
    130                 135                 140                 
Pro His Phe Ala Leu Ala Arg Gly Lys Lys Ala Val Glu Trp Glu Leu
145                 150                 155                 160 
Leu Thr Leu Asn Met Pro Ser Ala Ala Val Pro Leu Pro Arg Met Leu
                165                 170                 175     
Ala Gly Gln Ala Gly Met Thr Trp Ala Pro Glu Lys Asn Pro Gly Arg
            180                 185                 190         
Ala Ala Glu Gly Glu Val Val Gly Cys Ser Glu Ile Asp Phe Cys Gln
        195                 200                 205             
Cys Arg Ser Glu Leu Arg Cys Ser Gly His Arg Ala Ser Ala Thr Leu
    210                 215                 220                 
Met His Glu Ala Ser Leu Gln Lys Pro Gly Val Gln Thr Asn Gly Asn
225                 230                 235                 240 
Pro Val Cys Trp Ile Gln Thr Gly Ile Gln Ser Ser Gly Asn Ile Ile
                245                 250                 255     
Leu Ala Leu Gly Ser Gly Lys Trp Gly Glu Asp Gly Phe Arg Gly Lys
            260                 265                 270         
Lys Val Gln Asp Asn Val Met Ser Lys Cys Gln Asp Phe Lys Gln Phe
        275                 280                 285             
Glu Thr Phe Pro Pro Ser Leu Val His Ile
    290                 295             


<210> 2787
<211> 93
<212> PRT
<213> Homo sapiens

<400> 2787
Met Ala Phe Arg Gly Ser Thr Ser Arg Gly Glu Gly Ser Lys Ala Gln
 1               5                  10                  15      
Lys Thr Ile Cys Glu Cys Glu Thr Asn Met Gln Phe Thr Glu Gly Lys
            20                  25                  30          
Lys Gly Lys Gly Leu Ile Tyr Asp Thr Leu Ile Cys Gln Ser Val Glu
        35                  40                  45              
Leu Trp Gly Thr Ala Thr Lys Val Ile Val Asn Ser Thr Gly Leu Met
    50                  55                  60                  
Asn Arg Tyr Ser Phe Pro Asn Phe Tyr Cys Cys Thr Pro Gln Leu Ser
65                  70                  75                  80  
Asp Cys Gln Ala Asn Ala Lys Ala Gln Val Pro Phe Glu
                85                  90              


<210> 2788
<211> 300
<212> PRT
<213> Homo sapiens

<400> 2788
Met Pro Leu Gly Phe Gln Ile Gln Ser Leu Gly Thr Lys Leu Phe Gln
 1               5                  10                  15      
Glu Asp Pro Glu Gly Leu Ala Gly Arg Gly Lys Gly Gln Ala Val Pro
            20                  25                  30          
Glu Thr Gly Gly Ala Arg Lys Cys Gly Ala Trp Val Ser Thr Ala Ser
        35                  40                  45              
Glu Pro Thr Val Ser Cys Ala Val Asp Thr Ser Leu Arg Lys Thr Asp
    50                  55                  60                  
Lys Ile Arg Ala Pro Val Gly Thr Ala Gly Glu Arg Asn Glu Gln Val
65                  70                  75                  80  
His Cys Ile Arg Cys Arg Lys Val Thr Asp Asp Ser Gly Gly Gly Glu
                85                  90                  95      
Gln Gly Phe Leu Cys Leu Lys Thr Ser Met Leu Gly Ala Pro Ser Pro
            100                 105                 110         
Val Glu Lys Pro Gly Ala Leu Asp Arg Glu Arg Arg Gly Arg Gly Gly
        115                 120                 125             
Asp Asn Gly Lys Pro Leu Leu Asp Pro Gly His Ser Gly Pro Ser Ala
    130                 135                 140                 
Pro Trp Ala Pro Ser Arg Ser Ser Pro Arg Ala Arg Arg Met Gly Val
145                 150                 155                 160 
Leu Val Gly Ala Thr Leu Ser Asp Pro Gln Gly Ser Glu Arg Asp Cys
                165                 170                 175     
Asp Val Ser Thr Leu Ser Arg Trp Gln Ser Arg Arg Glu Asp Glu Gly
            180                 185                 190         
Gly Thr Ser Cys Ser Ser Pro His Gln Ala Pro His Phe Leu Ser Pro
        195                 200                 205             
Ala Thr Val Pro Cys Arg Asp Arg Arg Val Leu Pro Gly Leu Arg Lys
    210                 215                 220                 
Ala Val Leu Ser Gly Gly Cys Gly Pro Gly Gly Pro Gly Ala Ser Ala
225                 230                 235                 240 
Gly Ser Val Ala Pro Thr Arg Arg Ser Gln Pro Gly Arg Thr Arg Val
                245                 250                 255     
Arg Ser Ser Gly Glu Ala Gly Val Leu Gly Gly Ala Arg Arg Thr Arg
            260                 265                 270         
Arg Gly Arg Ser Arg Val Lys Thr Glu Thr Ala Tyr Ala Asn Cys Leu
        275                 280                 285             
Arg Lys Ser Ser Ala Val Glu Ile Arg Asn His Leu
    290                 295                 300 


<210> 2789
<211> 557
<212> PRT
<213> Homo sapiens

<400> 2789
Met Val Gly Asp Gln Pro Cys Ser Ile Arg Gly Gly Leu Val Thr Ser
 1               5                  10                  15      
Leu Arg Ala Val Pro Ala Gln Leu Lys Ile His Ala Ala Lys Leu Glu
            20                  25                  30          
Ala Ile Val Tyr Ile Gln Asp Ala Ser Leu Leu Leu Ala Lys Gln Arg
        35                  40                  45              
Ala Lys Arg Ser Ser Val Asn Glu Ile Lys Leu Trp Gly Lys Arg Leu
    50                  55                  60                  
Cys Leu Lys Ser Pro Glu Asp Ser Val His Lys Gly Gln Gly Val Gly
65                  70                  75                  80  
Met Ser Tyr Arg Pro Cys Gln Trp Ala Thr Ser Gln Gly Asp Ile Ser
                85                  90                  95      
Pro Leu Leu Leu Leu Leu Ala Leu Ala Cys Pro Trp Asn Gly Ser His
            100                 105                 110         
Arg Phe Ser Ala Ala Arg Val Leu Trp Lys Ala Arg Ser Leu Pro Gln
        115                 120                 125             
Gly Glu Gly Ser Glu Ala Ala Glu Glu Arg Trp Cys Arg Ser Pro Leu
    130                 135                 140                 
Thr Ser Thr His Pro Gly Pro Ala Thr Lys Ala Gln Lys Glu Asn Asn
145                 150                 155                 160 
Val Ile Thr Val Ser Glu Arg Ser Thr Ser Lys Asn Gly Ile Arg Cys
                165                 170                 175     
Asp Lys Trp Leu Gly Tyr Gly Pro Gly Asp Ile Ser Leu Pro Ala Pro
            180                 185                 190         
Ala Glu Asn Val Phe Glu Pro Lys Tyr Glu Phe Cys Ile Thr Glu Asn
        195                 200                 205             
Cys Lys Lys Arg Asn Arg Asn Asn Tyr His Leu Leu Ser Val Tyr Asn
    210                 215                 220                 
Val Leu Val Asp Leu Leu Thr Ser Asn Gly Tyr Ala Pro Met Gln Thr
225                 230                 235                 240 
Phe Gln Lys Gly Lys Asn Glu Cys Phe Thr Leu Thr Pro Val Leu Gly
                245                 250                 255     
Thr Lys Leu Gln Ser Ser His Ser Val Thr Pro Pro Ser Phe Thr Pro
            260                 265                 270         
Lys Thr Pro Thr Pro Ser Pro Gln Arg Pro Pro Leu Ser Pro Leu Phe
        275                 280                 285             
Leu Asp Leu His Pro Gly Ser Ser Thr Arg Thr Leu Ala Pro Gly Pro
    290                 295                 300                 
Asp Cys Arg Gly Cys Gln Arg Lys Gly Arg Asp Gln Leu Ile Gln Gly
305                 310                 315                 320 
Gly Gln Ser Glu Pro Arg Pro Ser Ala Glu Leu Gly Phe Leu Val Thr
                325                 330                 335     
Ala Pro Arg Ala Gln Pro Leu Pro Val Asn Tyr Leu Pro Tyr Val Pro
            340                 345                 350         
Phe Ser Gln Thr Arg Asn Arg Leu Leu Gln Val Leu Gly Thr Glu Ser
        355                 360                 365             
Gly Ala Ser Gly Ala Ala Leu Asp Lys Gly Ala Trp His Pro Gly Ala
    370                 375                 380                 
Pro Pro Trp Pro Ser Gln Thr Gln Arg Ala Pro Thr Val Gln Ser Phe
385                 390                 395                 400 
Leu His Glu Arg Gly Ile Glu Gly Arg Arg Gln Cys Thr Leu Leu Cys
                405                 410                 415     
Pro Ser Glu Arg Asp Ala Ala Ala Ala Leu Ser Met Gly Pro Gln Pro
            420                 425                 430         
Ala Gly Ser Gly Glu Gly Met Lys Trp Val Val Ala Gln Pro Val Tyr
        435                 440                 445             
Glu Gly Arg Val Pro Ala Glu Glu Trp Val Pro His Ala Gln Arg Ala
    450                 455                 460                 
Pro Tyr Gln Pro Ser Lys Ala His Arg Glu His Leu Val Val Gln Ser
465                 470                 475                 480 
Lys Gly Cys Trp Ala Leu Lys Arg Ala Gly Gly Gln Val Ala Val Ser
                485                 490                 495     
Ser Asp Trp Glu Pro Ala Gly Cys Arg Gln Thr Gln Ala Leu Pro Gly
            500                 505                 510         
Cys Arg Ala Ser Ala Ser Arg Ile Glu Ala Glu Ala Cys Ile His Ala
        515                 520                 525             
Cys Asn Pro Ser Gly Pro Ala Asn Ile Arg Leu Leu Leu Val Phe Leu
    530                 535                 540                 
Arg Lys Ser Lys Glu Arg Asn Asn Glu Leu Ala Leu Ala
545                 550                 555         


<210> 2790
<211> 268
<212> PRT
<213> Homo sapiens

<400> 2790
Met Ser Gly Leu Val Leu Gly Gln Arg Asp Glu Pro Ala Gly His Arg
 1               5                  10                  15      
Leu Ser Gln Glu Glu Ile Leu Gly Ser Thr Arg Val Val Ser Gln Gly
            20                  25                  30          
Leu Glu Ala Leu Arg Ser Glu His Gln Ala Val Leu Gln Ser Leu Ser
        35                  40                  45              
Gln Thr Ile Glu Cys Leu Gln Gln Gly Gly His Glu Glu Gly Leu Val
    50                  55                  60                  
His Glu Lys Ala Arg Gln Leu Arg Arg Ser Met Glu Asn Ile Glu Leu
65                  70                  75                  80  
Gly Leu Ser Glu Ala Gln Asp Pro Arg Ile Pro Gln Gly Pro Ser Pro
                85                  90                  95      
Pro Gly Lys Ala Lys Thr Leu Lys Arg Gly Lys Trp Val Leu Ser Ala
            100                 105                 110         
Ser Leu Asp Glu Lys Asn Thr Met Thr Lys Gly Val Ile Leu Arg Val
        115                 120                 125             
Met Pro Ser Asp Lys Pro Leu Ser Pro Ala Lys Val Leu Arg Gly Thr
    130                 135                 140                 
Asp Phe Asn Phe Gly Phe Ser Thr Ser Asn Ser Leu Ser Glu Cys Ser
145                 150                 155                 160 
Gln Ala Asp Gly Cys Pro Lys Ala Thr Asp Phe Met Glu Leu Cys Cys
                165                 170                 175     
Lys His Val Ala Ala Cys Ala Asp Arg Glu Gln Ala Leu His Val Phe
            180                 185                 190         
Leu Arg Glu Gly Cys Ala Val Cys Ser Glu Glu Thr Asp Gln Pro Ser
        195                 200                 205             
Pro Ser Pro Gly Arg Thr Pro Lys Thr Thr Gly Ile His Val Gln Arg
    210                 215                 220                 
Met Thr His Leu Arg Ile Arg Ser Val Glu Leu His Asp Phe His Ser
225                 230                 235                 240 
Ala Leu Thr Phe Val Asp Ala Asp Ile Val Phe Thr Ser Ile Cys Cys
                245                 250                 255     
Leu Asp Ile Glu Thr Ile Ile Asp Ile Tyr Met Ala
            260                 265             


<210> 2791
<211> 127
<212> PRT
<213> Homo sapiens

<400> 2791
Met Pro Glu Val Ser Ser Lys Gly Ala Thr Ile Ser Lys Lys Gly Phe
 1               5                  10                  15      
Lys Lys Ala Val Val Lys Thr Gln Lys Lys Glu Gly Lys Lys Arg Lys
            20                  25                  30          
Arg Thr Arg Lys Glu Ser Tyr Ser Ile Tyr Ile Tyr Lys Val Leu Lys
        35                  40                  45              
Gln Val His Pro Asp Thr Gly Ile Ser Ser Lys Ala Met Ser Ile Met
    50                  55                  60                  
Asn Ser Phe Val Thr Asp Ile Phe Glu Arg Ile Ala Ser Glu Ala Ser
65                  70                  75                  80  
Arg Leu Ala His Tyr Ser Lys Arg Ser Thr Ile Ser Ser Arg Glu Ile
                85                  90                  95      
Gln Thr Ala Val Arg Leu Leu Leu Pro Gly Glu Leu Ala Lys His Ala
            100                 105                 110         
Val Ser Glu Gly Thr Lys Ala Val Thr Lys Tyr Thr Ser Ser Lys
        115                 120                 125         


<210> 2792
<211> 317
<212> PRT
<213> Homo sapiens

<400> 2792
Met Lys Gly Gln Trp Ser Ile Ile Phe Gly Leu Thr Phe Ile Glu Glu
 1               5                  10                  15      
Met Gly Thr Arg Gln Gln Glu Glu Asn Gln Gln Leu Arg Ser Leu Asp
            20                  25                  30          
His Arg Val Trp Gly Ser Cys Tyr Trp Asp Val Met Glu His Trp Gly
        35                  40                  45              
Val Phe Pro Pro Arg Glu Ser Met Arg Ala His Ser Leu Ile Ser Leu
    50                  55                  60                  
Glu Asp Leu Asp Trp Leu Pro Leu Asn Gln Thr Phe Ser Gln Val Ser
65                  70                  75                  80  
Glu Leu Val Leu Asn Val Thr Ile Ser Thr Leu Thr Phe Leu Gln Gln
                85                  90                  95      
His Gly Val Ala Val Thr Glu Pro Val Tyr His Leu Ser Met Gln Asn
            100                 105                 110         
Ile Val Trp Asp Pro Gln Lys Val Gln Tyr Asp Leu Lys Ser Gln Phe
        115                 120                 125             
Gly Phe Asp Asp Leu His Thr Glu Gln Ile Leu Asn Ser Ser Ala Glu
    130                 135                 140                 
Leu Lys Glu Ile Pro Thr Asp Thr Ser Leu Glu Lys Met Val Cys Ser
145                 150                 155                 160 
Val Leu Ser Ser Thr Ser Glu Asp Glu Ala Glu Lys Trp Gly His Val
                165                 170                 175     
Gly Gly Cys His Pro Lys Trp Ser Glu Ala Lys Asn Tyr Leu Val His
            180                 185                 190         
Ala Val Ser Trp Leu Arg Val Tyr Gln Gln Val Leu Ser Pro Leu Ser
        195                 200                 205             
Met Phe Cys Ser Lys Val Phe Val Gln Trp Gln Gln Gly Ser Leu Leu
    210                 215                 220                 
Gln Lys Thr Leu Thr Gly Met Gly His Ser Leu Glu Ala Leu Arg Asn
225                 230                 235                 240 
Gln Phe Glu Glu Glu Ser Lys Pro Trp Lys Val Val Glu Ala Leu His
                245                 250                 255     
Thr Ala Leu Leu Leu Leu Asn Asp Ser Leu Ser Ala Asp Gly Pro Lys
            260                 265                 270         
Asp Asn His Thr Phe Pro Lys Ile Asp Val Leu Gly Pro Glu Val Leu
        275                 280                 285             
Ala Leu Lys Ala Glu Ile Gln Phe Pro Ile Arg Ala Ile Lys Ala Thr
    290                 295                 300                 
Gly Gly Trp Met Gln Gly Ala Ser Lys Asp Ala Leu Lys
305                 310                 315         


<210> 2793
<211> 76
<212> PRT
<213> Homo sapiens

<400> 2793
Met Ala Leu Gly His Asn Arg Thr Ser Asn Gln Leu Gly Asp Leu Lys
 1               5                  10                  15      
Leu Asp Asp Ile Phe Leu Lys Ala Thr Asp Ile Val Leu Lys Glu Val
            20                  25                  30          
Ala Glu Ile Leu Ser Ser Val Tyr Leu Lys Ser Val Phe Ile Gly Tyr
        35                  40                  45              
Phe Leu Val Ser Phe Ile Leu Gly Glu Asp Asp Asn Thr Met Gln Lys
    50                  55                  60                  
Glu Lys His Asp Ile Ile Asn Phe Asp Thr Lys Phe
65                  70                  75      


<210> 2794
<211> 161
<212> PRT
<213> Homo sapiens

<400> 2794
Met Ser Asn Ser Met Glu Ile Ser Leu Ile Cys Asp Asn Glu Phe Gln
 1               5                  10                  15      
Cys Arg His Ser Gln Leu Glu Cys Gly Tyr Gly Leu Gln Ser Asp Arg
            20                  25                  30          
Trp Thr Glu Tyr Ser Ile Gln Thr Met Gly Pro Asp Asn Leu Glu Leu
        35                  40                  45              
Ile Phe Asp Phe Phe Glu Glu Asp Leu Ser Glu His Ile Val Gln Gly
    50                  55                  60                  
Asp Ala Leu Pro Gly Cys Val Gly Thr Ala Cys Leu Leu Ser Ser Thr
65                  70                  75                  80  
Ile Ala Glu Ser Gly Lys Ser Ala Gly Ile Leu Thr Leu Pro Ile Met
                85                  90                  95      
Ser Arg Asn Ser Arg Lys Thr Ile Gly Lys Val Arg Val Asp Tyr Ile
            100                 105                 110         
Ile Ile Lys Pro Leu Pro Gly Tyr Ser Cys Asp Met Lys Ser Ser Phe
        115                 120                 125             
Ser Ser Ile Gly Ser Gln Glu Tyr His Trp Met Leu Ala Ile Glu Val
    130                 135                 140                 
Trp Glu Thr Leu Gln Leu Pro Ser Trp Leu Lys Lys Ile Leu Leu Leu
145                 150                 155                 160 
Leu
    


<210> 2795
<211> 163
<212> PRT
<213> Homo sapiens

<400> 2795
Met Pro Ala Leu Pro Ile Ser Arg Ile Gln Val Arg Leu Gly Glu His
 1               5                  10                  15      
Asn Val Glu Val Leu Glu Gly Asn Glu Gln Phe Ile Asn Ala Ala Lys
            20                  25                  30          
Ile Ile Arg His Pro Lys Tyr Asn Ser Trp Thr Leu Asp Asn Asp Ile
        35                  40                  45              
Leu Leu Ile Lys Leu Ser Met Pro Ala Ile Ile Val Ser Phe Ser Gly
    50                  55                  60                  
Leu Ile Tyr Thr Ser Thr Phe Phe Val Leu Leu Leu Ile Leu Thr Ala
65                  70                  75                  80  
Asn Tyr Pro Asp Glu Leu Gln Cys Leu Asp Thr His Val Leu Thr Gln
                85                  90                  95      
Ala Asp Cys Glu Ala Ser Tyr Pro Gly Glu Ile Thr Asn Asn Met Phe
            100                 105                 110         
Cys Gly Asp Ser Gly Gly Pro Val Val Cys Asn Gly Gln Leu Gln Gly
        115                 120                 125             
Val Val Ser Trp Gly Tyr Gly Cys Ala Gln Lys Asn Arg Pro Gly Val
    130                 135                 140                 
Tyr Thr Lys Val Tyr Asn Tyr Val Asp Trp Ile Lys Asp Thr Ile Ala
145                 150                 155                 160 
Ala Asn Ser
            


<210> 2796
<211> 114
<212> PRT
<213> Homo sapiens

<400> 2796
Met Glu Glu Thr Glu Ile Leu Leu Val Lys Gln Asn Lys Pro Leu Asn
 1               5                  10                  15      
Arg Leu Phe Gln Ser Gly Phe Cys Thr Gly Asp Gln Val Asp Ser Ala
            20                  25                  30          
Val Ala Lys Ala Asn Ser Arg Pro Pro Leu Phe Pro Val Gly His Val
        35                  40                  45              
Arg Gln Met His Leu Asp Ser Cys Leu Pro Gln Pro Leu Ser Glu Ser
    50                  55                  60                  
Ser Lys Lys Ala Asn Leu Cys Phe Asp Phe Pro Ile Arg Lys Asn Glu
65                  70                  75                  80  
Glu Ala Val Ser Thr Ser Gly Arg Asn Glu Pro Gly Arg Gly Thr Gly
                85                  90                  95      
Thr Ile Ser Glu Ala Met Pro Leu Arg Leu Glu Leu Ala Leu Ser Pro
            100                 105                 110         
Arg Arg
        


<210> 2797
<211> 201
<212> PRT
<213> Homo sapiens

<400> 2797
Met Phe Ser Ala Phe Phe Asp Gly Phe Pro Val Phe Thr Ile Asp Leu
 1               5                  10                  15      
Lys Phe Ala Lys Ile Asp Tyr Gln Thr Pro Glu Arg Ala Asp Lys Ser
            20                  25                  30          
Pro Phe Pro Phe Leu Pro Ser Val His Phe Ser Asp Phe Ser Ala Ser
        35                  40                  45              
Phe Glu Ile Val Gly Asp Gly Asp Val Asp Ser Ile Phe Ser Ala Leu
    50                  55                  60                  
Ser Glu Glu Leu Arg Lys Glu Leu Ala Ala Leu Arg Arg Arg Ile Pro
65                  70                  75                  80  
Arg Gly Ala Ala Ala Ser Asp Ser Asn Thr Lys Cys Arg Ser Gly Gly
                85                  90                  95      
Arg Gly Lys Ser Pro Ala Ala Arg Val Pro Pro Tyr Glu Tyr Glu Arg
            100                 105                 110         
Leu Leu Thr Gly Ser Lys Val Asn Pro Ser Thr Lys Leu Asp Leu Pro
        115                 120                 125             
Leu Lys Tyr Phe Thr Glu Val Ile Ile Ala Val Leu Met Leu Gln Met
    130                 135                 140                 
Lys Lys Asp Met Arg Arg Lys Ser Lys Gln Phe Ala Ser Gln Cys Thr
145                 150                 155                 160 
Ala Arg Lys Phe Trp Arg Gln Asp Leu Cys Thr Gly Met Ser Gly Pro
                165                 170                 175     
Arg Ile His Val Leu Asp Pro Ala Ile Ser Gly Val Phe Ala Ile Leu
            180                 185                 190         
His Ile Pro Val Thr Val His Pro His
        195                 200     


<210> 2798
<211> 585
<212> PRT
<213> Homo sapiens

<400> 2798
Met Thr Ala Ala His Ala Lys Ala Leu Ile Ser Tyr Leu Glu Leu Glu
 1               5                  10                  15      
Glu Ala Pro Lys Leu Leu Leu Gly Ser Glu Ala Ile Leu Ala Asn Pro
            20                  25                  30          
Gln Ser Ala Phe Leu Thr Cys Asn Ile Ser Arg Asp His His Leu Ser
        35                  40                  45              
Gly Ser Val Lys Pro Pro Arg Arg Ala Cys Lys Val Asn Ser Ser Gln
    50                  55                  60                  
Lys Ser Val Leu Trp Lys Asn Cys Ser Glu Met Ala Thr Gln Gly His
65                  70                  75                  80  
Gly Tyr Pro His Thr Gln Ile Leu Lys Ala Thr Leu Gly Tyr Asn Ser
                85                  90                  95      
Gly Asn Val Gln Gln Gly Lys Ile Arg Val Phe Gln Gln Lys Leu Glu
            100                 105                 110         
Lys Arg Lys Tyr Asn Ala Phe Thr Gly Gln Lys Tyr Cys Gly Arg Gly
        115                 120                 125             
Ala Ser Ile Gly Thr Val Gly Val Lys Lys Met Arg Ser Ser Thr Leu
    130                 135                 140                 
Gln Asp Pro Arg Arg Arg Asp Pro Gln Asp Asp Val Tyr Val Asp Ile
145                 150                 155                 160 
Thr Asp Arg Leu Arg Phe Ala Ile Leu Tyr Ser Arg Pro Lys Ser Ala
                165                 170                 175     
Ser Asn Val His Tyr Phe Ser Ile Asp Asn Glu Leu Glu Tyr Glu Asn
            180                 185                 190         
Phe Ser Glu Asp Phe Gly Pro Leu Asn Leu Ala Met Val Tyr Arg Tyr
        195                 200                 205             
Cys Cys Lys Ile Asn Lys Lys Leu Lys Ser Ile Thr Met Leu Arg Lys
    210                 215                 220                 
Lys Ile Val His Phe Thr Gly Ser Asp Gln Arg Lys Gln Ala Asn Ala
225                 230                 235                 240 
Ala Phe Leu Val Gly Cys Tyr Met Val Ile Tyr Leu Gly Arg Thr Pro
                245                 250                 255     
Glu Ala Ala Tyr Arg Ile Leu Ile Phe Gly Asp Thr Pro Tyr Ile Pro
            260                 265                 270         
Phe Arg Asp Ala Ala Tyr Gly Ser Cys Asn Phe Tyr Ile Thr Leu Leu
        275                 280                 285             
Asp Cys Phe His Ala Val Lys Lys Ala Met Gln Tyr Gly Phe Leu Asn
    290                 295                 300                 
Phe Asn Ser Phe Asn Leu Asp Glu Tyr Glu His Tyr Glu Lys Ala Glu
305                 310                 315                 320 
Asn Gly Asp Leu Asn Trp Ile Ile Pro Asp Arg Phe Ile Ala Phe Cys
                325                 330                 335     
Gly Pro His Ser Arg Ala Arg Leu Glu Ser Gly Tyr His Gln His Ser
            340                 345                 350         
Pro Glu Thr Tyr Ile Gln Tyr Phe Lys Asn His Asn Val Thr Thr Ile
        355                 360                 365             
Ile Arg Leu Asn Lys Arg Met Tyr Asp Ala Lys Arg Phe Thr Asp Ala
    370                 375                 380                 
Gly Phe Asp His His Asp Leu Phe Phe Ala Asp Gly Ser Thr Pro Thr
385                 390                 395                 400 
Asp Ala Ile Val Lys Arg Phe Leu Asp Ile Cys Glu Asn Ala Glu Gly
                405                 410                 415     
Ala Ile Ala Val His Cys Lys Ala Gly Leu Gly Arg Thr Gly Thr Leu
            420                 425                 430         
Ile Ala Cys Tyr Ile Met Lys His Tyr Arg Met Thr Ala Ala Glu Thr
        435                 440                 445             
Ile Ala Trp Val Arg Ile Cys Arg Pro Gly Leu Val Ile Gly Pro Gln
    450                 455                 460                 
Gln Gln Phe Leu Val Met Lys Gln Thr Ser Leu Trp Leu Glu Gly Asp
465                 470                 475                 480 
Tyr Phe Arg Gln Arg Leu Lys Gly Gln Glu Asn Gly Gln His Arg Ala
                485                 490                 495     
Ala Phe Ser Lys Leu Leu Ser Gly Val Asp Asp Ile Ser Ile Asn Gly
            500                 505                 510         
Val Glu Asn Gln Asp Gln Gln Glu Pro Lys Pro Tyr Ser Asp Asp Asp
        515                 520                 525             
Glu Ile Asn Gly Val Thr Gln Gly Asp Arg Ser Arg Ala Leu Lys Arg
    530                 535                 540                 
Arg Arg Gln Ser Lys Thr Asn Asp Ile Leu Leu Pro Ser Pro Leu Ala
545                 550                 555                 560 
Val Leu Thr Phe Thr Leu Cys Ser Val Val Ile Trp Trp Ile Val Cys
                565                 570                 575     
Asp Tyr Ile Leu Pro Ile Leu Leu Phe
            580                 585 


<210> 2799
<211> 307
<212> PRT
<213> Homo sapiens

<400> 2799
Met Val Phe Ile Val Ile Leu Arg Ser Val Ile Ser Gly Asp Thr Phe
 1               5                  10                  15      
Ala Cys Val Leu Ile Leu Ala Val Phe Leu Ser Leu Gln Thr Glu Asp
            20                  25                  30          
Asn Asn Thr Tyr Val Ile Gln Leu Leu Phe Thr Glu Leu Lys Gly Thr
        35                  40                  45              
Gly Tyr Lys Val Pro Gln Asp Val Leu Gln Lys Leu Leu Glu Ser Leu
    50                  55                  60                  
Gln Asn His Phe Gln Glu Asp Glu Gln Phe Leu Gly Ala Phe Met Pro
65                  70                  75                  80  
Arg Leu Gly Ile Gly Met Asp Thr Cys His Ser Phe Glu Thr Arg Asp
                85                  90                  95      
Leu Tyr Ala Met Gly Val Thr Glu Cys Asp Asn Met Leu Met Leu Leu
            100                 105                 110         
Gly Val Ser Asn Lys Met Thr Asn Arg Glu Met Asp Lys Val Met Pro
        115                 120                 125             
Leu Ile Ile Gln Gly Phe Lys Asp Ala Ala Glu Glu Ala Glu Thr Ser
    130                 135                 140                 
Val Met Gly Gly Gln Thr Val Leu Asn Pro Trp Ile Val Leu Gly Arg
145                 150                 155                 160 
Val Thr Thr Thr Val Cys Gln Pro Ser Glu Phe Ile Met Pro Asp Asn
                165                 170                 175     
Ala Val Pro Gly Asp Val Leu Val Leu Thr Lys Pro Leu Gly Thr Gln
            180                 185                 190         
Gly Ala Val Ala Val His Gln Trp Leu Asp Ile Pro Lys Lys Trp Asn
        195                 200                 205             
Asn Ile Lys Leu Val Val Thr Gln Glu Asp Val Glu Leu Ala Tyr Glu
    210                 215                 220                 
Glu Val Met Met Asn Met Ala Arg Leu Asn Arg Thr Gly Gly Leu Leu
225                 230                 235                 240 
Ile Cys Leu Pro Cys Glu Gln Thr Ala Arg Phe Cys Ala Glu Ile Lys
                245                 250                 255     
Ser Pro Lys Tyr Gly Glu Asp His Gln Ala Trp Ile Ile Gly Ile Val
            260                 265                 270         
Glu Lys Gly Asn His Thr Ala Arg Ile Ile Asp Lys Pro Leu Ile Ile
        275                 280                 285             
Glu Ile Ala Pro Gln Val Ala Thr Gln Asn Val Asn Pro Thr Pro Gly
    290                 295                 300                 
Ala Thr Ser
305         


<210> 2800
<211> 218
<212> PRT
<213> Homo sapiens

<400> 2800
Met Leu Ile Ser Asp Gly Asp Glu Glu Glu Gln Glu Gly Val Arg Gly
 1               5                  10                  15      
Glu Arg Asp Asp Val Glu Asp Leu Gly Leu Tyr Gly Asn Ser Glu Cys
            20                  25                  30          
Ile Glu His Leu Pro Gly Glu Ser Tyr Pro Arg Phe Gln Asp Gln Glu
        35                  40                  45              
Lys Leu Cys Asn Gln Ser Val Phe Ile Ser Trp Ser Leu Trp Ile Ser
    50                  55                  60                  
Pro Ser Arg Asp Ser Pro Leu Pro Ser Glu Thr Pro Ala Phe Cys Ser
65                  70                  75                  80  
Gly Gly Glu Ala Glu Lys Arg Glu Arg Arg Glu Gly Pro Gly Arg Gly
                85                  90                  95      
Gly Leu Gly Ala Arg Gly Cys Ser Pro Gly Ser Pro Val Arg Arg Arg
            100                 105                 110         
Ser Leu Ser Arg Ala Gly Pro Leu Cys Ser Gly Thr Asp Gln Gly Gly
        115                 120                 125             
Gly Arg His Thr Ala Arg Ser Phe His Pro Arg Ala Pro Thr Arg Thr
    130                 135                 140                 
Arg Ala Gly Ser Arg Tyr Leu Gln Val Ala Glu Pro Gly Ala Gly Leu
145                 150                 155                 160 
Asp Ser Ser Ser Gly Arg Arg Leu Arg Arg Arg Arg Leu Arg Leu Arg
                165                 170                 175     
Ala Pro Ser Arg Ser Ala Arg Ala Pro Ser Gly Ala Ala Thr Ala Glu
            180                 185                 190         
Leu Arg Ser Ala Leu Gly Gly Cys Arg Lys Phe Val Ser Glu Ala Glu
        195                 200                 205             
Cys Ile Ala Val Gly Ala Glu Ile Ile Gly
    210                 215             


<210> 2801
<211> 179
<212> PRT
<213> Homo sapiens

<400> 2801
Met Asp Glu Phe Ser Phe Ser Gly Asn Leu Leu Ser Leu Leu Ala Trp
 1               5                  10                  15      
Lys Val Lys Val Ser Ala Cys Val Asn Val Val Thr Arg Thr Ala Ser
            20                  25                  30          
Leu Gly Pro Trp Lys Ile Ala Gly Ala Ser Ala Trp Leu Leu Gly Ala
        35                  40                  45              
Pro Thr Arg Ala Ala Pro Thr Arg Ala Ala Pro Ala Cys Ser Leu Ala
    50                  55                  60                  
Ser Pro Glu Leu Glu Ala Gly Ala Asp Glu Gln Glu Asn Ser Ile Cys
65                  70                  75                  80  
Cys Trp Gly Lys Pro Ala Ser Ser Arg Gln Asp Lys Asn Ser Pro Ser
                85                  90                  95      
Val Leu Cys Arg Thr Trp Leu Ala Arg Ala Tyr Gln Gly Arg Lys Ala
            100                 105                 110         
Ala Gln Gln Gln Asn Leu Arg Pro Arg Leu Arg Pro Gln Arg Leu Phe
        115                 120                 125             
Pro Leu His Gln Leu His Leu Val Gln Leu Val Arg Asn Trp Gln Phe
    130                 135                 140                 
Asn Phe Ser Val Ile Gly Pro Thr Ala Val Ala Gln Gln Asn Leu Cys
145                 150                 155                 160 
Ile Pro Leu Ala Gly Gly Cys Leu Ala Ala Pro Tyr Ala Tyr Gln Pro
                165                 170                 175     
Val Arg Leu
            


<210> 2802
<211> 639
<212> PRT
<213> Homo sapiens

<400> 2802
Met Arg Gln Ser Pro Leu Tyr Gly Leu Gly Pro Ile Ala Glu Ser Val
 1               5                  10                  15      
Ala Arg Leu Leu Gly Gly Ser Phe Trp Val Leu Arg Gln Pro Gly Lys
            20                  25                  30          
Ala Ala Thr Gln Ile Val Arg Leu Phe Ala Ile Gln Pro Gln Glu Gly
        35                  40                  45              
Leu Ser Gln Thr Val Val Asp Ser His Ala Pro Ala His Gly Cys Gln
    50                  55                  60                  
Asp Pro Gly His His Thr Arg Gly Trp Ser Cys Gly Phe Glu Arg Gly
65                  70                  75                  80  
Ser Ser Leu Val Arg Leu Leu Leu Leu Ser Ser Trp Arg Lys Pro Trp
                85                  90                  95      
Phe Cys Phe Pro Ser Thr Pro Asn Cys Lys Val Thr Leu Ala Ala Pro
            100                 105                 110         
Asp Gln Lys Cys Asn Ser Glu Gly Pro Pro Lys Thr Gly Ala Arg Arg
        115                 120                 125             
Thr Leu Asn Pro Ala Ser Gln Gly Arg Cys Glu Glu Glu Asn Asn Pro
    130                 135                 140                 
Ala Asn Thr Cys Asp Thr Ser Ser Asn Asn Arg Leu Thr Arg Ser Leu
145                 150                 155                 160 
Phe Arg Ser Ala Ile Asn Ile Ile Tyr Ser Glu His Leu Lys Tyr Leu
                165                 170                 175     
Leu Ser Thr Pro Leu Ile Gly Leu Leu Asp Pro Pro Asp Thr Gln Ala
            180                 185                 190         
Leu Glu Gly Cys Lys Ala Gly Arg Thr Pro Arg Leu Thr Ser Thr Glu
        195                 200                 205             
Lys His Thr Thr Gly Leu Glu Gly Ser Gln Phe Leu Asp Val Ile Arg
    210                 215                 220                 
Thr Glu Ala Ala Phe Arg Lys Leu Gly Met Val Asp Pro Arg Leu Asp
225                 230                 235                 240 
Arg Ala Gly Val Thr Glu Val Thr Gly Gln Gly Arg Cys Glu Lys Asp
                245                 250                 255     
Gly Arg Gln Gly Arg Cys Leu Ser Asn Gly Arg Lys Tyr Gly Cys Val
            260                 265                 270         
Ser Asp Thr Glu Gln Phe Pro Thr Pro Arg Thr Gln Ile Thr Trp Asp
        275                 280                 285             
Gln Arg Lys Glu Thr Lys Gly Ser Thr Ile Phe Leu Glu Ala Lys Ala
    290                 295                 300                 
Met Thr Phe Ala Asn Ser Gln Leu Phe Glu Ala Phe Lys Pro Val Pro
305                 310                 315                 320 
Ile Met Ala His Lys Pro Phe Leu Ala Pro Asn Gln Asn His Thr Leu
                325                 330                 335     
Gln Ser Phe Lys Pro Leu Ile Arg Val Gln Ala Tyr Gln Thr Leu Lys
            340                 345                 350         
Gly Ser Gly Thr Glu Leu Leu Ala Arg Ala Ala Asp Pro Lys Pro Leu
        355                 360                 365             
Val Lys Ser Leu Gly Lys Ser Gln Gly Pro Gly Pro Gly Leu His Arg
    370                 375                 380                 
Cys Ala Lys Phe Pro Gln Asp Ser Cys Ser Met Glu Ala Leu Pro Trp
385                 390                 395                 400 
Glu Pro Val Asn Leu Glu Leu Trp Val Ile Lys Gln Arg Arg His Lys
                405                 410                 415     
Pro Gly Pro Ser Leu Lys Arg Ala Leu Gly Arg Ala Gln Asn Trp Ile
            420                 425                 430         
Val Leu Ser Ala Ser Leu Ile Ile Leu Val Val Thr Ser Glu Leu Ala
        435                 440                 445             
Leu Cys His Asn Val Phe Leu Glu Val Thr Glu Pro Glu Thr His Arg
    450                 455                 460                 
Leu Leu Gln Ala Arg Ser Ser Pro Lys Ala Leu Asn Lys Gly Gly Ser
465                 470                 475                 480 
Gln Ser Arg Pro Ala Gly Val Pro Trp Gly Pro Arg Pro Ser Trp Asp
                485                 490                 495     
Arg Pro Asp Leu His Val Asn Ala Pro Ala His Tyr Thr Leu Ala Pro
            500                 505                 510         
Ser Ser Thr Gly Ala Cys Lys Thr Pro Thr Pro Phe Lys Ala Pro Pro
        515                 520                 525             
Gly His Arg Val Pro Gln Gly Ala Pro Gly Met Pro Arg Gly Pro Pro
    530                 535                 540                 
Ser Ser Pro Glu Ser Ala Arg Ser Ser Arg Ala Pro Pro Pro Pro Ala
545                 550                 555                 560 
Gln Arg Arg Pro Arg Ala Gly Ser Ala Pro Trp Ala Val Gly Trp Ala
                565                 570                 575     
Pro Ala Ser Trp Ser Trp Pro Ser Asp Pro Cys Arg Arg Glu Glu Pro
            580                 585                 590         
Ser Gln Gly Pro Ser Ala Ala Pro Gly Ser Pro Arg Arg Arg Pro Pro
        595                 600                 605             
Arg Pro Thr Arg Gly Asp Pro Ala Leu Thr Gly Arg Leu Pro Pro Ala
    610                 615                 620                 
Ile Gly Trp Gly Tyr Pro Ala Thr Ala Arg Gly Asp Gly Arg Gly
625                 630                 635                 


<210> 2803
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2803
Met Ala Glu Pro Arg Ala Gly Gln Gly Pro Gly Ala Leu Ala Ser Ala
 1               5                  10                  15      
Pro Ser
        


<210> 2804
<211> 204
<212> PRT
<213> Homo sapiens

<400> 2804
Met Ser Gly Pro His Phe Gln Lys Val Trp Leu Gly Gln Leu Lys Glu
 1               5                  10                  15      
Thr Lys Ile Asn Val Ala Gly Arg Asn Leu Arg Leu Tyr Gly Leu Val
            20                  25                  30          
Gln Leu Leu Lys Gly Leu Glu Asp Arg Gln Asp Ala Ala Leu Ser Leu
        35                  40                  45              
Ser Pro Lys Leu Thr Ala Gln Cys Tyr Ala Ile Ser Ala Ser Leu Ser
    50                  55                  60                  
Ser Asn Gln Asn Thr Ala Ile Thr Pro Thr Leu Asp Gly Thr Phe Gly
65                  70                  75                  80  
Lys Asn Glu Leu Ser Glu Glu Thr Arg Gly Ile His Asp His Tyr Leu
                85                  90                  95      
Gln Cys Met Asp Val Trp Pro Leu Gly Ser Val Phe Ser Leu Pro Glu
            100                 105                 110         
Leu Glu Ile Thr Val Ala Lys Phe Gln Gly Leu Thr Leu Ala Gly Ser
        115                 120                 125             
Ser Ser Ser Leu Ala Gly Thr Asp Ser Thr Leu Tyr Glu Asp Pro Ile
    130                 135                 140                 
Ile Thr Gln Phe Cys Glu Leu Phe Ser Ala Phe Ala Val Ser Glu Lys
145                 150                 155                 160 
Pro Ser Leu Asn Gln Gln Ser Arg Val Glu Met Asn Gly Cys Gly Ser
                165                 170                 175     
Tyr Lys Pro Ser Ser Thr Ser Ser Leu His Pro Phe Ile Gln Arg Ile
            180                 185                 190         
Leu Arg Ser Gly Arg Leu Val Ala Gly Pro Glu Ser
        195                 200                 


<210> 2805
<211> 461
<212> PRT
<213> Homo sapiens

<400> 2805
Met Gln Cys Glu Arg Ile Leu Lys Val Lys Gln Val Lys Ser Ser Ser
 1               5                  10                  15      
Ile Glu Thr Gly Ser His Pro Arg Ile Ala Cys Phe Ile Ser Thr Glu
            20                  25                  30          
Ala Leu His Cys Gly Val Ala Val Glu Arg Ser Thr Asn Pro Ser Leu
        35                  40                  45              
Ala Leu Asn Phe Leu Gly Gly Thr Gly Cys Ile Phe Gln Ile Arg Ser
    50                  55                  60                  
His His Gln Leu Ser Ala Phe Pro Pro Arg Thr Arg Thr Ser Leu Ser
65                  70                  75                  80  
Lys Arg Lys Gln Lys Asp Ala Gln Thr Leu Leu Gln Pro Lys Leu Pro
                85                  90                  95      
Thr Gln Val His Arg Pro Thr Arg Lys Arg Ser Leu Gly Arg Glu Ala
            100                 105                 110         
Arg Gly Arg Arg Gln Leu Thr Gly Gly Thr Ala Arg Gln Gln Leu Pro
        115                 120                 125             
Pro Pro Pro Pro Lys Glu Pro Glu Pro Glu Arg Ala Gly Pro Glu Ala
    130                 135                 140                 
Ser Leu Ala Gly Ala Thr Ala Ala Ala Ala Thr Arg Arg Ser Thr Pro
145                 150                 155                 160 
Leu Asn Asn Gly Gln Arg Ala Asn Gly Thr Pro Thr Ala Arg Gly Lys
                165                 170                 175     
Trp Arg Glu Pro Thr Gly Thr Gly Ala Ala Asp Met Ile Ala Val Glu
            180                 185                 190         
Ser Lys Pro Asp Pro Gln Cys Gln Gly Leu Cys Lys Asp Glu Val Pro
        195                 200                 205             
Ile Ser Thr Leu Thr Gly Thr Asn Lys Arg Thr Ser Glu Asn Pro Tyr
    210                 215                 220                 
Ala Leu Ala Thr Lys Asn Ala Asn Val Leu Ser Thr Arg Glu Pro Pro
225                 230                 235                 240 
Cys Cys Asn Ser Phe Gln Ala Lys Ile Pro Glu Lys Gln Asn Thr Lys
                245                 250                 255     
Asn Thr Phe Tyr Leu His Arg Leu Thr Phe Ser Asn Tyr Arg Glu Glu
            260                 265                 270         
Glu Gly Ser Ser Arg Leu Ser Val Phe Asn Ser Arg Ser Leu Thr Val
        275                 280                 285             
Gly Leu Ala Phe Lys Pro Glu Thr Gln Trp Leu Arg Met Val Ala Lys
    290                 295                 300                 
Leu Pro Gln Pro Pro Pro Pro Pro His His Pro Ala Phe Gln Asp Ser
305                 310                 315                 320 
Leu Lys Thr Asn Phe Lys Gly Thr His Asp Arg Phe Pro Thr Ser Glu
                325                 330                 335     
Ser Ser Pro Ser Pro His Ile Lys Gly Leu Gln Thr Ser Glu Tyr Ala
            340                 345                 350         
Glu Asn Ile His Thr Thr Cys Pro Gln Leu Ser Cys Ala Gln Ser Ala
        355                 360                 365             
Leu Gly Thr Asn Gln Val Pro Cys Glu Asp Ala Lys Val Thr Val Thr
    370                 375                 380                 
Arg His Glu Pro Phe Arg Ser Phe Gln Ser Thr Lys Lys Asp Asp Trp
385                 390                 395                 400 
Cys Ile His Gly Tyr Tyr Ile Lys Leu Leu Gly Gln Gln Gly Asn Pro
                405                 410                 415     
Gly Ser Val Arg Pro Ile Pro Asn Thr Ala Ile Ile Ile Thr Thr Ala
            420                 425                 430         
Ile His Pro Val Pro Val Leu His Ser Ser His Asn Ser Ile His Gln
        435                 440                 445             
Cys Leu Thr Phe Gly Leu Pro Asn Gly Tyr Gly Ser Ser
    450                 455                 460     


<210> 2806
<211> 510
<212> PRT
<213> Homo sapiens

<400> 2806
Met Pro Gln Ile Ala Val Pro Met Gly Thr Ile Leu Gln Lys Thr Ile
 1               5                  10                  15      
Arg Leu Gln Glu Ser Met Arg Glu Gln Arg Thr Val Phe Glu Arg Cys
            20                  25                  30          
Lys Thr Gly Phe Ser Pro Arg Pro Cys Arg Gln Leu His Glu His His
        35                  40                  45              
Pro His Pro Gly Gln Ala Lys Ala Lys Ser Ala Thr Ser Thr Thr Ser
    50                  55                  60                  
His Leu Pro Leu Ala Leu Gln Pro Val Asn Leu Gly Glu Glu Glu Lys
65                  70                  75                  80  
Gly Asp Cys His Tyr Glu Phe Arg Asp Lys Val Lys Ser Val Phe Ile
                85                  90                  95      
Cys Met Gln Leu Asp Thr Thr Ala Cys His Leu Cys Gly Pro Phe Lys
            100                 105                 110         
Phe Ser Leu His Ile Leu Ile Ala Thr Leu Ser Val Gly Cys Tyr Leu
        115                 120                 125             
Lys Met Lys Tyr Asn Glu Asn Tyr Lys Ile Glu Lys Leu Asn Asn Asp
    130                 135                 140                 
Gln Cys Tyr Lys Gly Gln Glu Gly Asp His Leu Met Asn Ala Ser Lys
145                 150                 155                 160 
Glu Ala Ile Leu Val Met Glu Val Asn Cys Arg Ala Thr Ser Gln Gln
                165                 170                 175     
Asn Lys Phe Asn Gly Lys Thr Gln Lys Lys Leu Leu Arg Val Pro Glu
            180                 185                 190         
Ile His Val Asp Ile Leu Phe Asn Thr Gly Thr Gly Val Gly Met Leu
        195                 200                 205             
Lys Ile Lys Lys Ile Gly Asp Glu Asp Phe Ala Phe Ile Ser Lys Cys
    210                 215                 220                 
Lys Asp Pro Lys Val Arg Thr Ile Leu Leu Gln Gly Asn Gly Lys Glu
225                 230                 235                 240 
Thr Leu Ser Lys Met Asp His Asn Ile Gln Asp Ala Val Gln Val Tyr
                245                 250                 255     
Cys Asn Phe Leu Phe Asp Pro His Leu Val Pro Gly Asp Gly Ala Ser
            260                 265                 270         
Glu Met Ala Val Ile His Val Leu Thr Glu Lys Ser Lys Leu Gln Thr
        275                 280                 285             
Ser Arg Ala Ala Met Glu Thr Val Val Leu Leu Leu Trp Ile Asp Val
    290                 295                 300                 
Ile Thr Thr Gly His Lys Arg Lys Gly Lys Glu Gln Gly Gln Gln Gly
305                 310                 315                 320 
Lys Thr Thr Gly Ala Ser Lys Glu Arg Lys Asn Asp Thr Gly Val Asp
                325                 330                 335     
Phe Phe Ser Glu Ser Gln Lys Lys Thr Val Asn Pro Ser Asp Phe Pro
            340                 345                 350         
Ser Arg Gln Gly Ala Leu Leu Gly Asp Lys Lys Glu Lys Glu Pro Ser
        355                 360                 365             
Phe Ala Asn Phe Gly Leu Cys Leu Cys Leu Leu Leu Gly Cys Gln Leu
    370                 375                 380                 
Leu Gly Gly Asn Thr Gly Leu Glu Gln Ser Ser Ile Gly Pro Tyr Ser
385                 390                 395                 400 
Gly His Gly Gly Ala Thr Thr Glu His Val Glu Cys Ser Thr Leu Arg
                405                 410                 415     
Tyr Thr Thr Ser Leu Ser Thr Thr Gly Arg Glu Arg Gly Gly Pro Tyr
            420                 425                 430         
Leu Gly Pro Ala Glu Glu Cys Gly Arg Phe Ser Glu Ser Thr Ala Gly
        435                 440                 445             
Lys Asp Met His Tyr Pro Gly Gln Arg Val Asp Ser Tyr Phe Val Ser
    450                 455                 460                 
Asn Asp Lys Val His Leu Ile Asp Trp Cys Gly His Arg Glu Asn Tyr
465                 470                 475                 480 
Arg Gln Gly Pro Leu Arg Leu Ala Ser Ile His Asp Lys Leu Leu Met
                485                 490                 495     
Ile Leu Lys Ile Thr Thr Ser Ser Val Ser Arg Val Phe Asn
            500                 505                 510 


<210> 2807
<211> 179
<212> PRT
<213> Homo sapiens

<400> 2807
Met His Ser Leu Lys Lys Val Thr Phe Glu Asp Val Ala Ile Asp Phe
 1               5                  10                  15      
Thr Gln Glu Glu Trp Ala Met Met Asp Thr Ser Lys Arg Lys Leu Tyr
            20                  25                  30          
Arg Asp Val Met Leu Glu Asn Ile Ser His Leu Val Ser Leu Gly Tyr
        35                  40                  45              
Gln Ile Ser Lys Ala Tyr Ile Ile Leu Gln Leu Glu Gln Gly Lys Glu
    50                  55                  60                  
Leu Trp Arg Glu Gly Arg Val Phe Leu Gln Asp Gln Asn Pro Asn Arg
65                  70                  75                  80  
Glu Ser Ala Leu Lys Lys Thr His Met Ile Ser Met His Pro Ile Thr
                85                  90                  95      
Arg Lys Asp Ala Ser Thr Ser Met Thr Met Glu Asn Ser Leu Ile Leu
            100                 105                 110         
Glu Asp Pro Phe Glu Cys Asn Asp Ser Gly Glu Asp Cys Thr Arg Ser
        115                 120                 125             
Ser Thr Ile Thr Gln Cys Leu Leu Thr His Ser Gly Lys Lys Pro Tyr
    130                 135                 140                 
Val Ser Lys Gln Cys Gly Lys Ser Leu Arg Asn Leu Leu Ser Thr Glu
145                 150                 155                 160 
Pro His Lys Gln Ile His Thr Lys Gly Arg Asn Pro Thr Ser Asn Trp
                165                 170                 175     
Met Ser Gly
            


<210> 2808
<211> 1037
<212> PRT
<213> Homo sapiens

<400> 2808
Met Asn Gly Ser Val Lys Arg Ala Val His Met Pro Ser Gln Ala Pro
 1               5                  10                  15      
Thr Pro Cys Asn Leu Ser Arg Gln Pro Phe Lys Pro Gln Ser Leu Pro
            20                  25                  30          
Pro Gln Arg Leu Ala Arg Thr Gln Ala Leu Ala Arg Pro Phe Gln Glu
        35                  40                  45              
Asp Val Leu Arg Asp Lys Ser Phe Ala Gly Ser Ile Pro Gln Ser Gly
    50                  55                  60                  
Ser Ala Lys Thr Ala Gly Leu Thr Gly Phe Cys Lys Leu Cys Lys Thr
65                  70                  75                  80  
Ser Ser Trp His Thr Gly Ala Ala Gln Ile Leu Glu Gly Gly Met Glu
                85                  90                  95      
Lys Ala Asn Ser Pro Gln Cys Ala Asp Val Arg Val Ser Gln Arg Gln
            100                 105                 110         
His Pro Ser Pro Ser His Ala Glu Gly Gln Ser Gln Ser Arg Ala Leu
        115                 120                 125             
His Gln Gly Trp Val Leu Leu Gln Gly Asn Val Ile Thr Gly Gln Lys
    130                 135                 140                 
Ala Ser Trp Lys Asp Arg Gly Phe Gly Val Pro Gln Thr Thr Val Cys
145                 150                 155                 160 
Arg Thr Arg Ser Ile Leu His Phe Leu Ala His Ile Leu Ala Ser Thr
                165                 170                 175     
Thr Val Tyr Leu Gly Cys Leu Pro Cys Pro Gly Arg Gln Pro Lys Pro
            180                 185                 190         
Ala Phe Leu Ala Pro Asp Pro Ser Val Leu Ala His Ile Ala Pro Trp
        195                 200                 205             
Val Pro Thr Thr Ser Ala Asn Glu Thr Asn Ala Asn Phe Leu Ser Leu
    210                 215                 220                 
Pro Asp Thr Val Ser Pro Glu Ile Arg Leu Asp His Ser Pro Pro Val
225                 230                 235                 240 
Pro Asp Arg Ser Val Ser Pro Leu Glu His Ile Pro Arg Thr Phe Pro
                245                 250                 255     
Lys Pro Gly Thr Gly Leu His Thr Ser Thr Pro Ser Arg Met Cys Ser
            260                 265                 270         
Val Ser Ser Ser Cys Ser Lys Asp Arg Pro Pro Thr Cys Ala Gly Ser
        275                 280                 285             
Thr Phe Ser Lys Gly Arg Met Gly Glu His Pro Thr Ile Ser His Leu
    290                 295                 300                 
Arg Thr Ala Phe Ile Arg Ser Leu Pro His Lys Leu Gln Glu Arg Tyr
305                 310                 315                 320 
Gly Arg Pro Thr Thr Phe Gln Arg Met Ala Met Ser Ser Cys Gln Leu
                325                 330                 335     
Glu Arg Ser Leu Pro Gly Lys Tyr Leu Tyr Leu Gly Arg Glu Ser Phe
            340                 345                 350         
Ser Leu Cys Ser Pro Ala Val Leu Lys Trp Lys Ser Lys Lys Pro Asp
        355                 360                 365             
Val Gly Gln Asn Thr Leu Ser Gln Gly Ala Gly Ser Ala Gly Pro Gln
    370                 375                 380                 
Cys Glu Ser Glu Leu Ala Arg Arg Lys Ile Pro Ala Thr Trp Met His
385                 390                 395                 400 
Leu Tyr Arg Ser Pro Arg Leu Thr Ile Thr Phe Leu Ile Trp Phe Gln
                405                 410                 415     
Pro Trp Met Leu Leu Pro Gly Ala Ser Ile Arg Asp Phe Arg Asp Ser
            420                 425                 430         
Ser Glu Leu Ser Pro Ser Asn Ala Arg Phe Cys Leu Thr Thr Gln Lys
        435                 440                 445             
Ser Leu Pro Arg Cys Leu Val Leu Gly Lys Ala Gln Gln Ala Val Glu
    450                 455                 460                 
Val Asp Asn Gln Ile Pro Arg Arg Asp Phe Ser Leu Ser Pro Ala Gly
465                 470                 475                 480 
Ala Val Gly Gln Thr His Pro Gly Ile Ile His Lys Arg Ser Ile Lys
                485                 490                 495     
Ala Trp Gly Gly Ala Asp Phe Leu Gly Leu Leu Asn Gly Asp Leu Ser
            500                 505                 510         
Leu Leu Ile Leu Ser Val Ile Gly Pro Gly Lys Pro Ser Lys Glu Leu
        515                 520                 525             
Ser Ser Phe Ser Arg Asp Leu Arg Glu Asn Ser Pro Glu Phe Ser Val
    530                 535                 540                 
Gln Val Thr Gln Ala Leu Asn Ala Val Thr Trp Thr Gly Arg Arg Gly
545                 550                 555                 560 
Cys His His Glu Gln Ala Ser Gln Thr Ala Ser Arg Ser Asn Pro Lys
                565                 570                 575     
Thr Gly Gln Gly Gly Ser Asp Ala Ala His Gly Glu Glu Gly Cys Pro
            580                 585                 590         
Cys Cys Leu Asn Gly Phe Arg Met Lys Thr Ala Leu Ser Pro Met Trp
        595                 600                 605             
Gly Ser Leu Thr Met Asn Pro Ile Ile Lys Thr Ser Ser Ala Glu Gln
    610                 615                 620                 
Met Val Lys His Lys Asn Met Trp Lys Glu Gln Arg Gly Gln Pro His
625                 630                 635                 640 
Tyr Pro Leu Lys Thr Ile Lys Val Ala Ala Leu Thr Glu Gly Tyr Ser
                645                 650                 655     
Ser Pro Ala Gly Pro His Leu Pro Ser Lys Pro Thr Cys Leu Pro Ser
            660                 665                 670         
Gly Arg Pro Ala Lys Pro His Arg Lys Ser Trp Gly Arg Lys Ala Glu
        675                 680                 685             
Ser Glu Pro Gln Glu Ala Ser Leu Ala Thr Gln Pro His Pro Thr His
    690                 695                 700                 
Thr Gly Pro Val Ile Gln Gly Pro Thr Phe Ala Gly His Arg Glu Leu
705                 710                 715                 720 
Thr Gly Thr Ala Leu Arg Gly Cys Lys Glu Leu Cys Leu Ser Val Pro
                725                 730                 735     
Leu Cys Arg Asp Gly Lys Arg Arg Ala Ile Ser Gly Met Glu Ala Ile
            740                 745                 750         
Cys Leu Leu Ser Thr Leu Ala Ala Gln Pro Glu Arg Glu Glu Lys Gln
        755                 760                 765             
Glu Asp Ala Gly Arg Val Arg Ser Trp Val Ser Ala Ala Ser Pro Gln
    770                 775                 780                 
Ser Ser Arg Ala Gly Leu Gly Gln Ala Trp Arg Gln Gly Leu Pro Pro
785                 790                 795                 800 
Tyr Pro Thr Thr Gly Pro Ser Pro Val Leu Gly Phe Cys Ala Ser Pro
                805                 810                 815     
Leu Gln Leu Gln Pro Gln Pro Leu Leu Phe Gly Arg Asp Val Val Leu
            820                 825                 830         
Leu Pro Pro Gly Pro Ala Ile Pro Ala Ser Gly Leu Ala Ser Gly Phe
        835                 840                 845             
Gly Ala Ala Gly Arg Ala Gly His Gly Trp Gly Ala Leu Pro Ala Pro
    850                 855                 860                 
Gly Glu Glu Glu Gly Tyr Gly Ala Ser Gly Leu Ser Ala Glu Leu Gly
865                 870                 875                 880 
Arg Leu Ser Ala Gly Ser Thr Arg Ser Gly Gln Ala Leu His Leu Leu
                885                 890                 895     
Pro Thr Pro Ala Arg Leu His Pro Asp Gly Leu Pro Ala Gln Gly Gly
            900                 905                 910         
Glu Lys Arg Arg Glu Ala Pro Arg Gly Trp Thr Ser Ala Thr Ala Thr
        915                 920                 925             
Leu Ser Leu Leu Leu Pro Lys Lys Glu Asn Pro Cys Asn Val Asp Ala
    930                 935                 940                 
Pro Leu Gln Glu Pro Gln Ala Asp Asn Asn Leu Pro Asp Leu Val Ser
945                 950                 955                 960 
Thr Leu Asp Ala Phe Thr Trp Asp Phe Arg Asp Ser Ser Glu Leu Ser
                965                 970                 975     
Pro Leu Asn Ala Arg Phe Cys Leu Thr Thr Gln Lys Ser Leu Pro Arg
            980                 985                 990         
Cys Leu Val Leu Arg Lys Thr Gln Gln Val Val Glu Val Asp Asn Gln
        995                 1000                1005            
Ile Pro Arg Arg Asp Phe Ser Leu Pro Pro Gly Gly Ala Val Gly Gln
    1010                1015                1020                
Thr His Thr Gly Ile Ile His Lys Arg Ser Ile Lys Ala
1025                1030                1035        


<210> 2809
<211> 216
<212> PRT
<213> Homo sapiens

<400> 2809
Met Gln Val Gln Arg Asp Ser Gly Cys Arg Leu Thr Arg Gly Gln Glu
 1               5                  10                  15      
Glu Gln Thr Ala Gly Gly Pro Ala Leu Gly Thr Pro Leu Pro Pro Glu
            20                  25                  30          
Gln Asp Thr Val Tyr Leu His Ser Pro Arg Lys Asp Pro Glu Ala Trp
        35                  40                  45              
Leu Ser Val Cys His Thr Gly Leu Ser Gly Arg Thr Phe Cys Phe Tyr
    50                  55                  60                  
Ser Glu Pro Leu Trp Glu Arg His Val Gln Ala Ala Gly Arg Ala Glu
65                  70                  75                  80  
Ser Leu Arg Ala Gly Gly Gly Ile Phe Ile Leu Arg Asp Val Gly Ser
                85                  90                  95      
Glu Gly Ala Glu Ala Arg Ser Ser Gly Lys Ala Pro Gly Gly Glu Val
            100                 105                 110         
Ala Ser Cys Ile Leu Met Lys Leu Cys Cys Val Val Val Glu Val Pro
        115                 120                 125             
Pro Thr Pro Ala Pro Gln Glu Ala Phe Ser His Leu Tyr Val Thr Pro
    130                 135                 140                 
His Ser Phe Gly Val Arg Phe Gly Ile Gly Asp Ala Gly Pro Cys His
145                 150                 155                 160 
Gly Ser Lys Gly Trp Gly Lys Gly Ser Ser Pro Gly Ala Gly Cys Ile
                165                 170                 175     
Gln Thr Ala Val Leu Leu Met Ala Pro Met His Phe Gly Ser Arg Leu
            180                 185                 190         
Ala Glu Gln Leu Val Gly Glu Leu Cys Gly Ala Thr Asn Cys Tyr Pro
        195                 200                 205             
Gln Ala Leu Ile Gly Gly Gly Pro
    210                 215     


<210> 2810
<211> 178
<212> PRT
<213> Homo sapiens

<400> 2810
Met Glu Ala Leu Asn Thr Ala Gln Gly Ala Arg Asp Phe Ile Tyr Ser
 1               5                  10                  15      
Leu His Ser Thr Glu Arg Ser Cys Leu Leu Lys Glu Leu His Arg Phe
            20                  25                  30          
Glu Ser Ile Ala Ile Ala Gln Glu Lys Leu Glu Ala Pro Pro Pro Thr
        35                  40                  45              
Pro Gly Gln Leu Arg Tyr Val Phe Ile His Asn Ala Ile Pro Phe Ile
    50                  55                  60                  
Gly Phe Gly Phe Leu Asp Asn Ala Ile Met Ile Val Ala Gly Thr His
65                  70                  75                  80  
Ile Glu Met Ser Ile Gly Ile Ile Leu Gly Ile Ser Thr Met Ala Ala
                85                  90                  95      
Ala Ala Leu Gly Asn Leu Val Ser Asp Leu Ala Gly Leu Gly Leu Ala
            100                 105                 110         
Gly Tyr Val Glu Ala Leu Ala Ser Arg Leu Gly Leu Ser Ile Pro Asp
        115                 120                 125             
Leu Thr Pro Lys Gln Val Asp Met Trp Gln Thr Arg Leu Ser Thr His
    130                 135                 140                 
Leu Gly Lys Ala Val Gly Val Thr Ile Gly Cys Ile Leu Gly Met Phe
145                 150                 155                 160 
Pro Leu Ile Phe Phe Gly Gly Gly Glu Glu Asp Glu Lys Leu Glu Thr
                165                 170                 175     
Lys Ser
        


<210> 2811
<211> 207
<212> PRT
<213> Homo sapiens

<400> 2811
Met Ala Arg Glu Ser Ala Ala Cys Leu Gly Val Ser His Arg Ala Asp
 1               5                  10                  15      
Ser Gly His Gln Ala Gly Ser Ala Leu Pro Gln Asp Ala Ala Thr His
            20                  25                  30          
Phe Glu Val Ile Gly Ser His Phe Pro Arg Arg Pro Ala Gln Glu Gly
        35                  40                  45              
Phe Lys Leu Cys Ala Gln Gly Leu Lys Glu Glu Gly Ala Gly Pro Pro
    50                  55                  60                  
Gln Ser Asn Thr Trp Met Pro Glu Phe Leu Ser Leu Arg Gly Ser Lys
65                  70                  75                  80  
Leu Arg Phe Ala Gln Gly Ala Thr Gln Asp Arg Ser Ser Glu Gly Ala
                85                  90                  95      
Val Gly Ala Arg Ser Pro Val Ile Thr Pro Leu Gln Asn Ala Trp Arg
            100                 105                 110         
Ser His Gln Pro Ile Thr Gln Thr Gly Val Thr Leu Pro Glu Lys Ala
        115                 120                 125             
Val Leu Lys Ser Ser Thr Leu Asn Pro His Pro Ala Ala Gly Ala Leu
    130                 135                 140                 
Leu Arg Ser Thr His Ala Phe Pro Val Gln Asn Ala Val Leu His Gln
145                 150                 155                 160 
Arg Glu Arg Pro Tyr Ala Thr Gly Ile Phe Lys Ala Thr Phe His Lys
                165                 170                 175     
Ser Lys His Lys Glu Asp Leu Thr His Ser Tyr Ser Val Leu Gln Gly
            180                 185                 190         
Arg Ile Asn Pro Asn Asn Pro Tyr Met Ile Asn Asp Ser Val Val
        195                 200                 205         


<210> 2812
<211> 210
<212> PRT
<213> Homo sapiens

<400> 2812
Met Val Asp Thr Glu Val Leu Leu Trp Met Leu Lys Met Val Asp Phe
 1               5                  10                  15      
Thr Ala Ala Ser Cys Gly Asp Phe Leu Leu Asp Gln Gln Thr Leu Thr
            20                  25                  30          
Pro Leu Leu Glu Leu Ile Pro Thr Asp Asp Glu Leu His Leu Ala Cys
        35                  40                  45              
Glu Met Lys Ile Ala Lys Pro Leu Ile Glu Ser Lys Leu Ser Gly Ser
    50                  55                  60                  
Thr Ser Ser Ala Gln Ser Thr Phe Ala Lys Met Asn Asp Ala Val Ser
65                  70                  75                  80  
Val Phe His Asn Leu Arg Gly His Asn Gly Leu Met Gly Phe Lys Leu
                85                  90                  95      
Trp Gly Lys Ile Ser Leu Phe Ile Ser Glu Arg Gly Ser Lys Asn Cys
            100                 105                 110         
Thr Val Ile Leu Leu Tyr Asp Gly Glu Thr Gly Gly Asp Ser Pro Met
        115                 120                 125             
Ser Leu Lys Leu Asn His Gly Arg Ile Leu Glu Ala Arg Val Tyr Cys
    130                 135                 140                 
Cys Pro Arg Gln Ser Gly Gln Phe Ser Tyr Phe Cys Ser Phe Gln Gly
145                 150                 155                 160 
Arg Thr Asn Ser His Pro Leu Thr Asn Ile Leu Phe Ser Met Arg Lys
                165                 170                 175     
Arg Asn Gln Met Leu Ser Lys Gln Cys Arg Phe Val Cys Arg Arg Arg
            180                 185                 190         
Leu Glu Ala Trp Val Lys Pro Trp Val Ser Leu Gly Asp Ile Leu Gly
        195                 200                 205             
Leu Ser
    210 


<210> 2813
<211> 470
<212> PRT
<213> Homo sapiens

<400> 2813
Met Thr Leu Ala Arg Asn Pro Ala Arg Val Thr Gln Glu Ala Ala Leu
 1               5                  10                  15      
Gln Phe Leu Arg Cys Asp Ile Gln Ile Phe His Leu Glu Tyr Ser Phe
            20                  25                  30          
Gln Ser Lys His Lys Gly Ile Val Gln Ile Asp Arg His Leu Ala Pro
        35                  40                  45              
Val Lys Val Gln Asn Val Ser Arg Gly Met Asp Ser Arg Ser Ser Cys
    50                  55                  60                  
Arg Leu Arg Gly Trp Met Asp Ala Ala Val Arg Arg Gly Thr Gly Ile
65                  70                  75                  80  
Ala Lys Val Lys Arg Ile Lys Ile Lys Gly Glu Gly Phe Asn Cys Asp
                85                  90                  95      
Val Gln Ile Ala Thr Ser Ser Thr Cys Ser Gly Lys Gln Ser Gly Gln
            100                 105                 110         
Gly Leu Pro Thr Arg Tyr Pro Ser His Arg Ala Ser Ile Leu Pro Trp
        115                 120                 125             
Leu Ala Phe Leu Ser Ala Gly Arg Gln Ala Gly Gln Arg Arg Gln Trp
    130                 135                 140                 
Asn Gln Thr Ala Val Arg Lys Gly His Thr Ala Met Thr Pro Arg Gly
145                 150                 155                 160 
Gly Ala Gln Val Thr Leu Glu Glu Met Glu Val Ser Gln Arg Gly Ser
                165                 170                 175     
Ile Trp Gly Glu Pro Gln Gly Ala Gly Ala Gln Ser His Ser Asp Trp
            180                 185                 190         
Leu Gln Pro Pro Gly Arg Val Gly Ile Gln Asp Thr Ser Trp Trp Thr
        195                 200                 205             
Glu Gln Arg Gln Ser Ser Trp Ser Asp Gly Ser Gly Tyr Val Phe Thr
    210                 215                 220                 
Gln Pro Phe Arg Asp Val Ala Cys Leu His Cys Gly Asn Ala Ser Gly
225                 230                 235                 240 
Gln Pro Val Pro Ala Val Gly Ala Arg Gly Gln Cys Ser Ala Arg Glu
                245                 250                 255     
Tyr Ser His Arg His Val Arg Ala Asp Ser Gly Tyr Ser Glu Glu Gly
            260                 265                 270         
Pro Ala Ala Arg Leu Gly Leu Gly Arg Leu Pro Gly Arg Gly Ala Ala
        275                 280                 285             
Arg Val Phe Leu Lys Asp Glu Leu Glu Ser Ala Pro Gly Ala Gly Ala
    290                 295                 300                 
Arg Cys Arg Glu Arg Ala Glu Leu Gly Gly Ala Leu Gln Gly His Tyr
305                 310                 315                 320 
Leu Asp Pro Ala Arg Trp Ala Pro Ser Ala Asp Ser Glu Gly Ser Ser
                325                 330                 335     
Thr Ser Pro Pro Gly Leu Gln Gly Gly Pro Asp Thr Phe Gln Glu Ala
            340                 345                 350         
Val Leu Asp Lys Gly Ser Arg Ile Cys Arg Ala Gly Arg Gly Lys Gly
        355                 360                 365             
Ser Val Asp Asn Gln Met Ala Phe Lys Pro Thr Glu Asp Gly Tyr Ile
    370                 375                 380                 
Leu Lys Arg Gly Asn Gln His Phe Ile Gln Ile Tyr Leu Glu Pro Lys
385                 390                 395                 400 
Trp Tyr Lys Pro Ser Ser Glu Tyr Arg Lys Asn Arg Lys Lys Leu Met
                405                 410                 415     
Leu Thr Ser Asp Ile Trp Ile Cys Asp Glu Ala Arg Gly Leu Cys Glu
            420                 425                 430         
Asp Trp His Leu Leu Pro Arg Glu Ala Leu Ser Leu Val Leu Ser Cys
        435                 440                 445             
Asp Leu Asn Ile Gly Leu Glu Gly Glu Arg Asn Gly Gln Arg Leu Gly
    450                 455                 460                 
Phe Ala Ser Asp Ala Thr
465                 470 


<210> 2814
<211> 671
<212> PRT
<213> Homo sapiens

<400> 2814
Met Ser Ala Gly Ala Thr Ser Val Leu Cys Pro Leu Ser Leu Leu Cys
 1               5                  10                  15      
Leu Leu Gln Thr Pro Ala Thr Ala Ile Ile Phe Ser Gln Leu Asp His
            20                  25                  30          
Phe Thr Val Pro Thr Arg Ala Pro Cys Val His Thr Ala Ala Arg Asp
        35                  40                  45              
Thr Arg Lys Gly Asp Trp Val Ile Pro Pro Leu Ser Ser Ser Pro Val
    50                  55                  60                  
Ala Ser His Leu His Leu Glu Thr Ala Arg Pro Asn Thr His Gly Thr
65                  70                  75                  80  
Pro Lys Asn Val Cys Arg Ser Ala Leu Leu Ser Ala Ser Asn Asp Ala
                85                  90                  95      
Gly Ser Glu Met Gln Gln Glu Gln Val Gln Pro Leu Ala Val Arg Glu
            100                 105                 110         
Trp Thr Pro Leu Ile Pro Thr His Leu Val Arg Pro Phe Ala Leu Thr
        115                 120                 125             
Gly Ala Ile Ser Asp Asp Leu Gln Ala Thr Cys Gln Ser Phe Ser Thr
    130                 135                 140                 
Leu Gln Pro Val Gly Leu Pro Val Ser His Thr Cys Pro Ser Leu Gly
145                 150                 155                 160 
Trp Met Met Met Ala Val Pro Trp Gln Pro Leu Ala Ala Ala Val Pro
                165                 170                 175     
Asp Thr Pro Cys Ser Arg Pro Leu Ser Cys Pro Ser Tyr Trp Thr Lys
            180                 185                 190         
His Leu Leu Ala Leu Glu Thr Pro Ala Ile Phe His Gly Phe Cys Tyr
        195                 200                 205             
Gly Cys Ser Pro Met Ala Pro Pro Ser Ile Met Ala Thr Ile Ile Thr
    210                 215                 220                 
Pro Ala Arg Pro Gln Thr Ser Ser Pro Ile Pro Asn Thr Ala Leu Gly
225                 230                 235                 240 
Gly His Leu Pro Pro Ser His Lys Pro Gln Glu Lys Glu Ala Pro Gly
                245                 250                 255     
Arg Asp Gly Cys Arg Thr Phe Gln Lys Gly His Arg Ala Gly Val Arg
            260                 265                 270         
Gly Ser Asp His Leu Thr Leu Asp Arg Asp Gly Gln Trp Gln Asn Lys
        275                 280                 285             
Pro Lys Leu Gly Glu Pro Ala Ser Lys His Pro Ser Ser Ser Gly His
    290                 295                 300                 
Gln Ser Ala Arg Lys Thr Leu Gly Thr Glu Gly Thr Pro Gly Tyr Thr
305                 310                 315                 320 
Gln Glu Met Gln Leu Arg Glu Thr Ala Ala Leu Ser Ser Gln Arg Pro
                325                 330                 335     
Gln Leu Thr Ala Arg Leu Gly Ala Gln Glu Glu Ala Leu Val Leu Ala
            340                 345                 350         
Phe Arg Gly His Gln Leu Arg Thr Ser Thr Pro Pro Gln Pro Leu Thr
        355                 360                 365             
Leu Leu Asn His Gly Leu Ser Ser Leu Val Ser Arg Gly Cys Phe Thr
    370                 375                 380                 
Pro Gly Ser Leu Gly His Ser Ser His His Gly Lys Ala Met Gly Ser
385                 390                 395                 400 
Thr Trp Pro Ser Ser Ser Thr Gly Phe Ser Trp Val His Gly Pro Gly
                405                 410                 415     
Gly His Ser Trp Arg Pro Phe Gly Val Ala Pro Val Tyr Glu Arg Ala
            420                 425                 430         
Arg Lys Val Pro Lys Ser Cys Arg Gly Pro Ala His Leu Gly Leu Tyr
        435                 440                 445             
Arg Ala His Asn Gly Asp Thr Arg Gln His Pro Leu Glu Arg Thr Thr
    450                 455                 460                 
Gly Asn Leu Asn Asp Thr Thr Leu Thr Pro Ile Arg Phe Ser Glu Asp
465                 470                 475                 480 
Phe Arg Lys Cys Ser Ala Ile Arg Asp Thr Phe Ile Leu Ser Thr Thr
                485                 490                 495     
Val Leu Phe Gln Arg Val His Ser Leu Pro Gly Pro His Gln Gly Asn
            500                 505                 510         
Asn Leu Gln Lys Ala Ala Ser Asp Arg Asn Glu Pro Val Asp His Glu
        515                 520                 525             
Gly Gln Glu Lys Arg Arg Asp Ile Arg Lys Ala Gln Ser Gln Gln Leu
    530                 535                 540                 
Gln Gln Trp Gly Pro Pro Ser Thr Asp Gln Gly Gly Pro Gly Gly Leu
545                 550                 555                 560 
Pro Asp Pro Thr Ile Trp Gly Arg Ser Ala Ala Thr Arg Ala Ala Ser
                565                 570                 575     
Gly Met Arg Ala Ser Ser Pro Gly Arg Val Asn Ile Ser Pro Glu Pro
            580                 585                 590         
Gly Gly Ala Cys Ala Ala Cys Gly Pro Ala Gly Ala Gln Arg Thr Lys
        595                 600                 605             
Gly Ser Arg Arg Cys Pro Val Pro Ala Ala Arg Pro Ala Glu Arg Ala
    610                 615                 620                 
Arg Ser His Val Pro Ala Pro Gly Leu Thr Gly Ala Gly Ser Arg Val
625                 630                 635                 640 
His Asp Phe Pro Glu His Ser Phe Thr Pro Trp His Arg Leu Ser Ala
                645                 650                 655     
Tyr Gly Cys Lys Ala Leu Phe Arg Ala Glu Asn Lys Gln Glu Phe
            660                 665                 670     


<210> 2815
<211> 358
<212> PRT
<213> Homo sapiens

<400> 2815
Met Ala Ala Asp His Val Gln Asn Glu Glu Asn Tyr Ala Gln Val Leu
 1               5                  10                  15      
Asp Lys Phe Gly Ser Asn Phe Leu Ser Arg Asp Asn Pro Asp Leu Gly
            20                  25                  30          
Thr Ala Phe Val Lys Phe Ser Thr Leu Thr Lys Glu Leu Ser Thr Leu
        35                  40                  45              
Leu Lys Asn Leu Val Arg His Phe Ile Phe Val Arg Ala Asn Ala Val
    50                  55                  60                  
Thr Ser Ala Glu Trp Gln Ser Asn Tyr Trp Gly Arg Lys Met Ile Glu
65                  70                  75                  80  
Asp Asp Pro Ser Thr Cys Lys Ile Phe Cys Leu Leu His Pro Arg Ser
                85                  90                  95      
Leu Tyr Pro Tyr Lys Ala Thr Thr Pro Asp Leu Asp Cys Trp Glu Val
            100                 105                 110         
Leu Gln Pro Ser Leu Val Leu Phe Ser Gly Leu Met Leu Ala Ser Thr
        115                 120                 125             
Gly Lys His Gly Leu Val Arg Gly Ala Trp Leu Asp Phe Arg Leu Pro
    130                 135                 140                 
Leu Tyr Lys Pro Gly Val Leu Glu Val Pro Phe Val Glu Leu Cys Ser
145                 150                 155                 160 
Ala Leu Leu Ser Glu Ala Arg Lys Asn Glu Ala Leu Leu Thr Asp Cys
                165                 170                 175     
Leu Ser Ala Ser Trp Leu Leu Gln Gln Asp Arg Leu Gln Gly Leu Ser
            180                 185                 190         
His Asn Val Ile Phe Thr Leu Asp Ser Leu Leu Lys Gly Asp Leu Lys
        195                 200                 205             
Gly Val Lys Gly Asp Leu Lys Lys Pro Phe Asp Lys Ala Trp Lys Asp
    210                 215                 220                 
Tyr Glu Thr Lys Phe Thr Lys Ile Glu Lys Glu Lys Arg Glu His Ala
225                 230                 235                 240 
Lys Gln His Gly Met Ile Arg Thr Glu Ile Thr Gly Ala Glu Ile Ala
                245                 250                 255     
Glu Glu Met Glu Lys Glu Arg Arg Leu Phe Gln Leu Gln Met Cys Glu
            260                 265                 270         
Tyr Leu Ile Lys Val Asn Glu Ile Lys Thr Lys Lys Gly Val Asp Leu
        275                 280                 285             
Leu Gln Asn Leu Ile Lys Tyr Tyr His Ala Gln Cys Asn Trp Asn Cys
    290                 295                 300                 
Asp Pro Gln Gly Glu Glu Asn Glu Ala Gln Arg Asp Ser Ala Asp Asp
305                 310                 315                 320 
Ser Met Ser Pro Phe Ala Phe Tyr Gly Val Thr Asp Thr Leu Leu Met
                325                 330                 335     
Thr Ala Met Val Ile Leu Phe Phe Tyr Asn Ser Ser Ser Phe Pro Ala
            340                 345                 350         
Pro Ile Ser Tyr Gln Asn
        355             


<210> 2816
<211> 97
<212> PRT
<213> Homo sapiens

<400> 2816
Met Met Lys Gly Thr Ser Ser Phe Gly Lys His Cys Asn Lys Thr Tyr
 1               5                  10                  15      
Thr Leu Cys His His Cys Gly Ser Lys Ala Tyr His Leu Gln Lys Ser
            20                  25                  30          
Thr Tyr Gly Lys Cys Gly Tyr Thr Ala Lys Arg Lys Arg Lys Tyr Asn
        35                  40                  45              
Trp Ser Thr Lys Ala Lys Arg Arg Asn Thr Thr Arg Thr Gly Gln Met
    50                  55                  60                  
Arg His Leu Lys Ile Val Tyr His Arg Phe Arg His Gly Phe Arg Glu
65                  70                  75                  80  
Gly Thr Thr Pro Lys Pro Lys Arg Ala Ala Val Ala Ala Ser Ser Ser
                85                  90                  95      
Ser
    


<210> 2817
<211> 167
<212> PRT
<213> Homo sapiens

<400> 2817
Met Ala Gln Arg Ala Leu Glu Gln Leu Lys Ser Val Gly Asp Asp Ser
 1               5                  10                  15      
Gly Gly Ala Val Leu Ala Gly Phe Leu Pro Thr Leu Gly Ile Leu Trp
            20                  25                  30          
Phe Gln Ser Pro Pro Phe Ala Lys Gln Leu Arg Tyr Pro Tyr Thr Gly
        35                  40                  45              
Glu Ser Pro Glu Ser Pro Gly Leu Gln Cys Arg Ile Pro Val Pro Leu
    50                  55                  60                  
Cys Val Arg Lys Ala Ala Arg Leu Tyr Leu Ser Cys Thr Leu Ser Ile
65                  70                  75                  80  
Glu Ser Cys Ala Glu Ser Pro His Pro His Leu Ser Glu Asn Val Ser
                85                  90                  95      
Ser Gly Leu Lys Pro Ala His Lys Gly Phe Ser Ser Ser Ser Ser Ser
            100                 105                 110         
Cys Leu Gly His Phe Leu Glu Leu Cys Glu Tyr Cys Gly Phe Ser Tyr
        115                 120                 125             
Ile Ser Leu Glu His Lys Asn Arg Arg Phe Trp Phe Val Thr Phe Glu
    130                 135                 140                 
Thr Ser Gly Lys Ser Lys Pro Glu Leu Ile Leu Asp Ala Glu Ala Ile
145                 150                 155                 160 
Asn Pro Tyr Cys Pro Leu Ser
                165         


<210> 2818
<211> 229
<212> PRT
<213> Homo sapiens

<400> 2818
Met Glu Thr Arg Val Phe Pro Ser His Met Gly Gly Lys Phe Ser Phe
 1               5                  10                  15      
Ser Ser Ala Arg Asp Leu Val Leu Leu Lys Thr Trp Glu Glu Val Leu
            20                  25                  30          
Gln Leu Ser Ser Phe Pro Gln Arg Gly Arg Asp His Ala Arg Thr Pro
        35                  40                  45              
Glu Phe Ser Asn Arg Arg Ser Thr Pro Arg Asp Ser Gln Phe Trp Glu
    50                  55                  60                  
Val Ile Ser Asp Glu His Ala Ile Asp Ser Ala Gly Thr Tyr His Gly
65                  70                  75                  80  
Asp Ser His Leu Gln Leu Glu Arg Ile Asn Val His His His Glu Ala
                85                  90                  95      
Ser Gly Gly Arg Tyr Val Pro Arg Ala Val Leu Val Asp Leu Glu Pro
            100                 105                 110         
Gly Thr Met Asp Ser Val Arg Ser Gly Pro Phe Gly Gln Val Leu Arg
        115                 120                 125             
Pro Asp Asn Phe Ile Phe Gly Glu Leu Arg Ala Arg Thr Gly Val Arg
    130                 135                 140                 
Leu Leu Ser Gln Gly Ser Ser Lys Ser Arg Asn Ala Pro Arg Ser Ser
145                 150                 155                 160 
Cys Gly Asn Cys Gly Ala Arg Ala Pro Glu His Pro Pro Ile Cys Arg
                165                 170                 175     
Val Glu Ser Leu Asn Leu Pro Leu Leu Asn Gly Leu Arg Glu Glu Val
            180                 185                 190         
Pro Gly Val Ser Ser Arg Ser Val Trp Gly Arg Lys Gln Leu Gly Gln
        195                 200                 205             
Gly Thr Leu His Arg Arg Arg Gly Ala Asp Gly Val Ser Asp Gly Arg
    210                 215                 220                 
Cys Gln Lys Gly Gly
225                 


<210> 2819
<211> 251
<212> PRT
<213> Homo sapiens

<400> 2819
Met Leu Glu Arg Glu Leu Glu Glu Leu Ala Phe Ile Glu Tyr Leu Leu
 1               5                  10                  15      
Pro Ala Ser Val Arg Ser Ala His His Ser Asp Leu Ser Ile Ser Leu
            20                  25                  30          
Arg Ile Val Pro Asp Leu Lys Pro Ala Gln Ala Thr Ser Asn Gln Gln
        35                  40                  45              
Cys Leu Leu Asn Ala Thr Thr Ser Val Gln Ala Leu Lys Pro Gly Ala
    50                  55                  60                  
Ser Trp Asp Leu Lys Gly Ala Arg Val Gln Asp Gly Leu Ser Ala Glu
65                  70                  75                  80  
Gln Asp Met Met Pro Ser Lys Leu Glu Gly Ser Leu Val Leu Pro His
                85                  90                  95      
Thr Pro Glu Ile Gln Thr Thr Arg Ser Asp Leu Gln Gly His Gln Ala
            100                 105                 110         
Val Pro Glu Arg Ser Ala Phe Ser Pro Pro Arg Arg Asn Phe Ser Pro
        115                 120                 125             
Ile Val Asp Thr Asp Ser Leu Ala Ala Gln Gly His Val Leu Thr Lys
    130                 135                 140                 
Ile Ser Lys Glu Asn Thr Arg His Pro Leu Pro Leu Arg His Asn Pro
145                 150                 155                 160 
Phe His Ser Leu Phe Gln Gln Thr Leu Thr Asp Lys Ser Gly Pro Glu
                165                 170                 175     
Leu Lys Thr Pro Phe Val Lys Glu Ala Phe Glu Glu Thr Pro Lys Lys
            180                 185                 190         
His Arg Glu Cys Leu Val Lys Asp Asn Gln Lys Tyr Thr Phe Thr Ile
        195                 200                 205             
Asp Arg Cys Ala Lys Asp Leu Phe Val Ala Lys Gln Val Gly Thr Lys
    210                 215                 220                 
Leu Ser Val Asn Glu Pro Leu Ser Phe Ser Val Glu Ser Ile Leu Lys
225                 230                 235                 240 
Arg Pro Ser Ser Ala Ile Thr Arg Val Ser Gln
                245                 250     


<210> 2820
<211> 188
<212> PRT
<213> Homo sapiens

<400> 2820
Met Gly Lys Met Ser Ala Gly His Val Arg Asp Leu Cys Ser Ser Ala
 1               5                  10                  15      
Ser His His Arg Pro Gly Gly Leu Gly Gly Lys Lys Trp Phe Cys Gly
            20                  25                  30          
Pro Gly Pro Arg Ser Pro Cys Cys Val Gln Pro Arg Asp Leu Val Pro
        35                  40                  45              
Cys Ile Pro Ala Ala Leu Val Met Ala Lys Arg Gly Gln Asp Thr Ala
    50                  55                  60                  
Gln Ala Leu Ala Ser Glu Gly Ala Ser Pro Lys Ser Trp His Leu Pro
65                  70                  75                  80  
Arg Ser Val Glu Pro Ala Gly Ala Gln Lys Ser Arg Thr Glu Val Trp
                85                  90                  95      
Glu Pro Leu Pro Arg Phe Gln Arg Met Tyr Gly Asn Ala Cys Met Ser
            100                 105                 110         
Arg Gln Lys Phe Ala Thr Gly Val Arg Pro Ser Trp Arg Thr Ser Val
        115                 120                 125             
Lys Ala Met Trp Lys Gly Lys Pro Pro His Arg Asp Pro Thr Gly Thr
    130                 135                 140                 
Leu Pro Ser Arg Ala Val Arg Arg Arg Pro Pro Ser Ser Arg His Gln
145                 150                 155                 160 
Asn Gly Ile Ser Thr Asp Ser Leu His His Ala Pro Gly Lys Ala Thr
                165                 170                 175     
Asp Thr Gln Arg Gln Pro Val Lys Ala Thr Glu Lys
            180                 185             


<210> 2821
<211> 1342
<212> PRT
<213> Homo sapiens

<400> 2821
Met Ser Cys Ile Gln Gln Asp Phe Ser Val Asn Gln Met Gly Ala Arg
 1               5                  10                  15      
Arg Arg Ser Arg Glu Glu Ala Glu Lys Pro Gln Lys Leu Leu Ser Ile
            20                  25                  30          
Ile Lys Ser Ser Ala Phe Gln Gln Gly Gln Gln Arg Thr Asp Ser Asn
        35                  40                  45              
Ser Gln Pro Ser Leu Arg Ala Met Pro Ser His Gly Leu Ser Glu Ala
    50                  55                  60                  
Leu Pro Asn Lys Leu Gln Thr Ile Ser Pro Ala His His Thr Leu Pro
65                  70                  75                  80  
Asn Gly Ile Phe Leu Ala Arg Lys Ala Asp Ser Gln Gly Trp Leu Pro
                85                  90                  95      
Leu Glu Arg Ser Val Arg Arg Ile Leu Cys Ala Asp Pro Cys Cys Gln
            100                 105                 110         
Ile Cys Asn Ser Val Ala Leu Glu Ile Gln Gln Leu Leu Val Gly Glu
        115                 120                 125             
Asn Asn Gln Ile Ser Leu Thr Leu Ser Gly Pro Leu Gln Gly Ser Ser
    130                 135                 140                 
Cys Leu Glu Met Leu Ser Thr Ser Ser Met Ser Leu Asp Gln Ser Leu
145                 150                 155                 160 
Glu Phe His Ser Trp His Thr Arg Glu Leu Ser Leu Ser Ser Val Thr
                165                 170                 175     
Pro Thr Leu Ser Gln Leu Thr Asp Gln Lys Ser Leu Thr Gln Ser Ala
            180                 185                 190         
Ala Gln Ser Thr Tyr Ala Asp Gly Ile Gln Asp Tyr Trp Ala Asp His
        195                 200                 205             
Leu Gln Leu Gly Gln Glu Phe Gln Val Pro Asp Val Leu Arg Gly Pro
    210                 215                 220                 
Asn Thr Ile Ala Ser Ser Arg Ile Glu Lys Pro Arg Ala Pro Leu Asn
225                 230                 235                 240 
Gln Glu Glu Met Thr Gln Ser Asn Pro Ser Leu Val Gln Gly Asn Gln
                245                 250                 255     
Gly Gln His His Leu Asn Ser Gln Val Ser Leu Leu Ser Leu Asn Pro
            260                 265                 270         
Glu Thr Leu Asn Arg Met His Pro Met Ala Leu His Met Val Leu Pro
        275                 280                 285             
Ala His Leu Pro Phe Leu Ser Pro Glu Val Leu Arg Leu Leu Glu Val
    290                 295                 300                 
His Val Lys Lys Trp Met His Phe Gln Arg Trp Gly Leu Pro Arg Arg
305                 310                 315                 320 
Val Glu Glu Ser Leu Arg Gln Leu Met Pro Asn Pro Pro Leu Tyr Tyr
                325                 330                 335     
Gln Pro Gly Asn Asp Gln Pro Val Ser Phe Asn Leu Lys Asn Thr Pro
            340                 345                 350         
Gln Val Ser Leu His Arg Phe Glu Thr Ile Ser Leu Gln Thr Trp Cys
        355                 360                 365             
Ser Cys Val Ala Gly Gln Pro Ile Gln Thr Phe Trp Val Ser Glu Trp
    370                 375                 380                 
Ser Thr Met Asn Pro Glu Gln Arg His His Cys Gln Gln Thr Pro Asn
385                 390                 395                 400 
Pro Met Ala Leu Ala Leu Pro Ser Pro Ala Leu Lys Ala Leu Ser Gly
                405                 410                 415     
Pro His Pro Gln Ser Gly Gly Gln Asp Asn Asp Ser Gly Ser Asp Leu
            420                 425                 430         
Gln Gln Lys Tyr Ser Gln Leu Phe Cys Gly Leu Pro Ser Leu His Ser
        435                 440                 445             
Glu Ser Leu Val Ala Thr Phe Met Gly Ser Gln Gly Leu Pro Lys Ile
    450                 455                 460                 
Glu Asn Val Pro Lys Pro Pro Leu Lys Asp Pro Phe Leu Phe Asn Glu
465                 470                 475                 480 
Leu Ser Phe Pro Gln Leu Leu Pro Lys Thr Ser Pro Gln Ser Ala Pro
                485                 490                 495     
Pro Ser Ser Pro Leu Ser Pro Asn Trp Met Ser Pro Ser Asp His Gln
            500                 505                 510         
Arg Ala Gln Ile Asn Val Pro Phe Leu Thr Leu Ala Glu Tyr Glu Ala
        515                 520                 525             
Leu Glu Trp His Leu Leu Gln Arg Gln Leu Gln Leu Gln Trp Gly Trp
    530                 535                 540                 
Pro Ala Ala Leu Gln Arg Ser Gln His Thr Gln Cys Leu Met Gln His
545                 550                 555                 560 
Glu Pro Cys Gly Lys Ala Gln Ser Pro Glu Thr Thr Thr Ala Ser Gln
                565                 570                 575     
Thr Gly Lys Ser Ile Ser Val Leu Thr Arg Glu Leu Leu Phe Phe Pro
            580                 585                 590         
Glu His Ala Arg Lys Leu Leu Glu Phe His Ile Gln Lys Gln Leu Ile
        595                 600                 605             
Arg His Arg Trp Gly Leu Pro Gln Lys Ile Gln Gln Ser Ile Gln Leu
    610                 615                 620                 
Leu Leu Thr Ser Thr Asp Gln Gln Thr Val Ser Ser Ser Ser Thr Ala
625                 630                 635                 640 
Leu Ala Asn Val Ser Ile Pro Gln Pro Val Ala Leu Glu Ala Asn Gly
                645                 650                 655     
Ala Cys Asp Val Leu Ser Pro Ile Ala Ala Pro Val Ser Ile Pro Arg
            660                 665                 670         
Pro His Leu Leu Thr Gln Val Lys Ala Ile Leu Gln Ser His Ile Asp
        675                 680                 685             
Ser Lys Cys Gly Gln Ile His Gln Gly Lys Ile Pro Ala Cys Val His
    690                 695                 700                 
Arg Ser Trp Asp Cys Arg Ile Ser Gly Val Leu Ala Val Ala Pro Phe
705                 710                 715                 720 
Pro Cys Ile Pro Glu Ser Gln Phe Leu Glu Leu Gln Thr Ala Ser Asp
                725                 730                 735     
Pro Asp Leu His His Lys Val Met Pro Trp Met Pro Thr Ala Leu Asp
            740                 745                 750         
Gln Gln Gln Gln Ala Leu Pro Gly Thr Val Thr Glu His Pro Lys Leu
        755                 760                 765             
Leu Arg Val Leu Ser Val Glu Ala Ile Glu Lys Leu Glu Thr Thr Leu
    770                 775                 780                 
Arg His Lys His Leu Ala Phe Leu Ser Gly Leu Pro Ala Leu Tyr Tyr
785                 790                 795                 800 
Val Ala Leu Pro Arg Ala Leu Ala Pro Ala Val Thr Ser Gln Ser Val
                805                 810                 815     
Ile Thr Glu Met Glu Pro Ser Pro Val Glu Ile Pro Ala Glu Pro Leu
            820                 825                 830         
Ile Gln Met Val Ser Phe Glu Glu Gln Cys Ile Ser Leu Gly Pro Cys
        835                 840                 845             
Pro Gln Gly Asn Asn Glu Ser Cys Thr Asp Val Ala Lys Glu Phe Gln
    850                 855                 860                 
Pro Ala Val Pro Val Lys Gly Thr Met Glu Thr Leu Pro Leu Glu Ser
865                 870                 875                 880 
Gln Thr His Pro Thr Ser Pro His Ser Leu Gln Thr His Ile Leu Thr
                885                 890                 895     
Lys Leu Asn Phe His Leu Arg Lys Lys Val Leu Glu Ile Gln Trp Gly
            900                 905                 910         
Ile Pro Ile Arg Ala Arg Lys Ser Arg Glu Gln Thr Val Ala Ala Pro
        915                 920                 925             
Glu Asn Ile Ser Thr Gln Lys Ser Leu Glu Ser Leu Asn His Gln Gly
    930                 935                 940                 
Glu Thr Leu Leu Gln Glu Leu Pro Ile Pro Pro Asp Thr Leu Pro Ala
945                 950                 955                 960 
Pro Asn Pro Glu Gly Val His Leu Lys Glu Gln Leu Ala Asn Asp Leu
                965                 970                 975     
Lys Ala Val Gln Gln Asn Gln Lys Gln Ser Asn Ser Lys Ala Val Pro
            980                 985                 990         
Gln Gly Ser Ala His Ser Val Ser Lys Ile Ser Gln Pro Ser Gly Asp
        995                 1000                1005            
Met Thr Glu Ala His Met Pro Cys Val Gln Val Glu Ala Asn Val Asn
    1010                1015                1020                
Lys Pro Ser Leu Glu Glu Pro Cys Gly Pro Glu Pro Gln Ser Pro Ser
1025                1030                1035                1040
Lys Ser Lys Asp Pro Ala His Val Pro Met Leu Ala Gly Asn Arg Glu
                1045                1050                1055    
Asp Pro Glu Glu Thr Lys Ala Ala Arg Asp His Arg Glu Gly Asp Ala
            1060                1065                1070        
Gly Phe Gly Arg Ser Ser Thr Arg Glu Glu Arg Arg Pro Ala Glu Asp
        1075                1080                1085            
Gln Arg Pro Ala Gly Met Leu Pro Asn Lys Thr Pro Arg Gly Ser Trp
    1090                1095                1100                
Arg Trp Ser Arg Ser Phe His Leu Ala Asp Pro Cys Gln His Ser Pro
1105                1110                1115                1120
Gln His His Pro Gln Leu Lys Leu Pro Gln Leu Pro Pro Arg Val Pro
                1125                1130                1135    
Gly Glu Lys Glu Ser Glu Lys Asp Leu Gln Asp Ser Gln Thr Lys Leu
            1140                1145                1150        
Thr Val Ile Leu Glu Pro Ala Thr Ile Pro Glu Asn Ala Gln Thr Val
        1155                1160                1165            
Leu Pro Gln Ala Ser Gln Gly Gln Pro Phe Leu Ser Gln Pro Thr Gln
    1170                1175                1180                
Ala Lys Pro Leu Gln Gly Gln Thr Leu Gln Gly Gln Val Leu His Gly
1185                1190                1195                1200
Leu Val Met Pro Val His Ala Gln Lys Lys Pro Ser Leu Thr Glu Ser
                1205                1210                1215    
Ser Phe Arg Asn Lys Ile Lys Cys Phe Leu Gln His Ile Asn Pro Lys
            1220                1225                1230        
Thr Lys Gly Lys Gly His Glu Asp Ser Met Phe Ser Ala Ala Ala Lys
        1235                1240                1245            
Val Ala Lys Thr Arg Lys Glu Asn Val Ala Lys Ser Leu Ala Pro Ala
    1250                1255                1260                
Lys Ser Pro Val Gly Arg Ser Lys Thr Glu Lys Pro Thr Gly Cys Ser
1265                1270                1275                1280
Lys Ala Gln Ser Arg Pro Ala Gln Lys Leu Val Gly Pro Ala Phe Leu
                1285                1290                1295    
Asp Gly Pro Gln Ser Leu Asp Asp Lys Leu Arg Leu His Ser Arg Gln
            1300                1305                1310        
Pro Gly Ser Ala Ser Ala Leu Gly Tyr Pro Arg His Cys Pro Arg His
        1315                1320                1325            
Cys Pro Arg Glu Ala Cys Ala Asn Lys Pro Gly His Pro Thr
    1330                1335                1340        


<210> 2822
<211> 184
<212> PRT
<213> Homo sapiens

<400> 2822
Met Ser Trp Ala Trp Ala Pro Val Thr Met Lys Gly Arg His Gly Cys
 1               5                  10                  15      
Leu Leu Arg Arg Arg Met Tyr Val Gln Gly Ala Gly Ala Ala Ala Arg
            20                  25                  30          
Glu Gly Phe Gln Glu Glu Val Thr Ser Gln Ala Gln Val Leu Val Glu
        35                  40                  45              
Ala Gly Leu Glu Ala Gly His Ser Arg Gly Pro Ala Gly Gly His His
    50                  55                  60                  
Gly Val Glu Gly Gln Ser Glu Ala Ile Leu Val Gly Ala Ile Gly Glu
65                  70                  75                  80  
Ala Phe Gly Lys Tyr Met Tyr Leu Val Leu Met Ser Ala Arg Lys Pro
                85                  90                  95      
Ser Asn Pro Glu Thr Asp Phe Glu Ala Arg Ser Gln Val Gln Thr Pro
            100                 105                 110         
Ala Thr Gln Ser Asn Pro Gly Pro Arg Lys Lys Asn Pro Val Met Ser
        115                 120                 125             
Gly Met Lys Val Pro Arg Trp Pro Leu Arg Asp Gly Glu Ala Ser Leu
    130                 135                 140                 
Pro Arg Ala Leu Gln Arg Gly Leu Val Phe Leu Asn Phe Trp Gly Pro
145                 150                 155                 160 
Ser Cys Ser Phe Lys Gly Ser Arg Ala Ile Val Glu Arg Leu Gln Gln
                165                 170                 175     
Pro Glu Thr Ser Thr Thr Ala Leu
            180                 


<210> 2823
<211> 570
<212> PRT
<213> Homo sapiens

<400> 2823
Met Asp Gly Tyr Leu Pro Arg Asn Gly Pro Glu Pro Phe His Pro Thr
 1               5                  10                  15      
Thr Asp Ala Thr Ser Cys Thr Glu Ile Asp Cys Gly Thr Pro Pro Glu
            20                  25                  30          
Val Pro Asp Gly Tyr Ile Ile Gly Asn Tyr Thr Ser Ser Leu Gly Ser
        35                  40                  45              
Gln Val Arg Tyr Ala Cys Arg Glu Gly Phe Phe Ser Val Pro Glu Asp
    50                  55                  60                  
Thr Val Ser Ser Cys Thr Gly Leu Gly Thr Trp Glu Ser Pro Lys Leu
65                  70                  75                  80  
His Cys Gln Glu Ile Asn Cys Gly Asn Pro Pro Glu Met Arg His Ala
                85                  90                  95      
Ile Leu Val Gly Asn His Ser Ser Arg Leu Gly Gly Val Ala Arg Tyr
            100                 105                 110         
Val Cys Gln Glu Gly Phe Glu Ser Pro Gly Gly Lys Ile Thr Ser Val
        115                 120                 125             
Cys Thr Glu Lys Gly Thr Trp Arg Glu Ser Thr Leu Thr Cys Thr Glu
    130                 135                 140                 
Ile Leu Thr Lys Ile Asn Asp Val Ser Leu Phe Asn Asp Thr Cys Val
145                 150                 155                 160 
Arg Trp Gln Ile Asn Ser Arg Arg Ile Asn Pro Lys Ile Ser Tyr Val
                165                 170                 175     
Ile Ser Ile Lys Gly Gln Arg Leu Asp Pro Met Glu Ser Val Arg Glu
            180                 185                 190         
Glu Thr Val Asn Leu Thr Thr Asp Ser Arg Thr Pro Glu Val Cys Leu
        195                 200                 205             
Ala Leu Tyr Pro Gly Thr Asn Tyr Thr Val Asn Ile Ser Thr Ala Pro
    210                 215                 220                 
Pro Arg Arg Ser Met Pro Ala Val Ile Gly Phe Gln Thr Ala Glu Val
225                 230                 235                 240 
Asp Leu Leu Glu Asp Asp Gly Ser Phe Asn Ile Ser Ile Phe Asn Glu
                245                 250                 255     
Thr Cys Leu Lys Leu Asn Arg Arg Ser Arg Lys Val Gly Ser Glu His
            260                 265                 270         
Met Tyr Gln Phe Thr Val Leu Gly Gln Arg Trp Tyr Leu Ala Asn Phe
        275                 280                 285             
Ser His Ala Thr Ser Phe Asn Phe Thr Thr Arg Glu Gln Val Pro Val
    290                 295                 300                 
Val Cys Leu Asp Leu Tyr Pro Thr Thr Asp Tyr Thr Val Asn Val Thr
305                 310                 315                 320 
Leu Leu Arg Ser Pro Lys Arg His Ser Val Gln Ile Thr Ile Ala Thr
                325                 330                 335     
Pro Pro Ala Val Lys Gln Thr Ile Ser Asn Ile Ser Gly Phe Asn Glu
            340                 345                 350         
Thr Cys Leu Arg Trp Arg Ser Ile Lys Thr Ala Asp Met Glu Glu Met
        355                 360                 365             
Tyr Leu Phe His Ile Trp Gly Gln Arg Trp Tyr Gln Lys Glu Phe Ala
    370                 375                 380                 
Gln Glu Met Thr Phe Asn Ile Ser Ser Ser Ser Arg Asp Pro Glu Val
385                 390                 395                 400 
Cys Leu Asp Leu Arg Pro Gly Thr Asn Tyr Asn Val Ser Leu Arg Ala
                405                 410                 415     
Leu Ser Ser Glu Leu Pro Val Val Ile Ser Leu Thr Thr Gln Ile Thr
            420                 425                 430         
Glu Pro Pro Leu Pro Glu Val Glu Phe Phe Thr Val His Arg Gly Pro
        435                 440                 445             
Leu Pro Arg Leu Arg Leu Arg Lys Ala Lys Glu Lys Asn Gly Pro Ile
    450                 455                 460                 
Ser Ser Tyr Gln Val Leu Val Leu Pro Leu Ala Leu Gln Ser Thr Phe
465                 470                 475                 480 
Ser Cys Asp Ser Glu Gly Ala Ser Ser Phe Phe Ser Asn Ala Ser Asp
                485                 490                 495     
Ala Asp Gly Tyr Val Ala Ala Glu Leu Leu Ala Lys Asp Val Pro Asp
            500                 505                 510         
Asp Ala Met Glu Ile Pro Ile Gly Asp Arg Leu Tyr Tyr Gly Glu Tyr
        515                 520                 525             
Tyr Asn Ala Pro Leu Lys Arg Gly Ser Asp Tyr Cys Ile Ile Leu Arg
    530                 535                 540                 
Ile Thr Ser Glu Trp Asn Lys Ile Arg His Ser Cys Cys Cys Arg Trp
545                 550                 555                 560 
Arg Val Leu Asp Trp Val Pro Trp Leu Leu
                565                 570 


<210> 2824
<211> 314
<212> PRT
<213> Homo sapiens

<400> 2824
Met Leu Ser Pro Pro Pro Ser Arg Arg Arg Arg Arg Gly Arg Gln Gly
 1               5                  10                  15      
Pro Asn Arg Glu Arg Thr Gly Tyr Leu Ser Gln Pro Arg Pro Thr Gly
            20                  25                  30          
His His Phe Arg Arg Leu Gly Val Thr Thr Gly Tyr Pro Gly Thr Arg
        35                  40                  45              
Arg Asn Phe Trp Val Thr Gly Gly Ile Ser Tyr Gly Asp Met Arg Met
    50                  55                  60                  
Leu Ala Asp Gly Glu Asp Ser Asp Lys Ser Arg Gln Leu Asp Ser Ile
65                  70                  75                  80  
Thr Ala Ser Phe Pro Leu Pro His Pro Trp Lys Asn Leu Lys Ser Ala
                85                  90                  95      
Asp Tyr Gln Met Gly Pro Gln Val Lys Cys Leu His Thr Pro Trp Arg
            100                 105                 110         
Gly Asp Asp Ser Ser Gly Arg Ser Asp Gln Pro Val Glu Met Arg Ala
        115                 120                 125             
Glu Glu His Ser Lys Arg Asp Asn Ile Cys Lys Asp Pro Val Ala Asn
    130                 135                 140                 
Arg Cys Met Val His Thr Arg Asn Leu His Lys Arg Gly Gly Ala Lys
145                 150                 155                 160 
Gln Asp Arg Arg Tyr Lys Gly Ala Thr Tyr Asp Thr Tyr Leu Val His
                165                 170                 175     
Asp Phe Gly Gln Lys Asp Gln Gly Ser Glu Leu Pro Leu Pro Ser Glu
            180                 185                 190         
Gln Lys Val Ser His Gln Leu Tyr Leu Arg Pro Met Pro Trp Gly Val
        195                 200                 205             
Glu Pro Pro Leu Ser Val Glu Ser Pro Pro Glu Pro Ser Ala Leu Gly
    210                 215                 220                 
Pro His Ile Ile His Ser Ser Ile Ile Arg His Glu Asp Thr Glu Val
225                 230                 235                 240 
Gly Glu Arg Arg Ile Pro Ser Leu Glu Glu Leu Thr Asp Lys Glu Ile
                245                 250                 255     
Asp Val Phe His Ala Ala Glu Ala Gly Ala Gly Trp Arg Glu Ile Arg
            260                 265                 270         
Glu Phe Thr Gln Asp His Val Asn Val Arg Ala Arg Ala Glu Leu Trp
        275                 280                 285             
Leu Cys Arg Leu Glu Val Lys Tyr Ile Thr Thr Leu Leu Leu Ala Phe
    290                 295                 300                 
Ala Asp Ser Ile Phe Gly Leu Ser Ala Ile
305                 310                 


<210> 2825
<211> 520
<212> PRT
<213> Homo sapiens

<400> 2825
Met Trp Leu Thr Cys Leu Cys His Cys Trp Met Ala Ser Trp Ser Thr
 1               5                  10                  15      
Ser Met Ser Leu Gly Gln Leu Ser Pro Ala Tyr Leu Asp Gln Ile Pro
            20                  25                  30          
Glu Met Phe Ala Asp Thr Arg Glu Thr Glu Thr Val Phe Val Pro Val
        35                  40                  45              
Ile Gln Ala Gly Met Glu Ala Leu Lys Ala Ala Glu Cys Ala Gly Lys
    50                  55                  60                  
Leu Phe Leu Phe His Thr Ser Leu Pro Ile Ala Glu Ala Pro Gly Lys
65                  70                  75                  80  
Leu Lys Asn Arg Asp Asp Arg Lys Leu Ile Asn Thr Asp Lys Glu Lys
                85                  90                  95      
Thr Leu Phe Gln Pro Gln Thr Gly Ala Tyr Gln Thr Leu Ala Lys Glu
            100                 105                 110         
Cys Val Ala Gln Gly Cys Cys Val Asp Leu Phe Leu Phe Pro Asn Gln
        115                 120                 125             
Tyr Val Asp Val Ala Thr Leu Ser Val Val Pro Gln Leu Thr Gly Gly
    130                 135                 140                 
Ser Val Tyr Lys Tyr Ala Ser Phe Gln Val Glu Asn Asp Gln Glu Arg
145                 150                 155                 160 
Phe Leu Ser Asp Leu Arg Arg Asp Val Gln Lys Val Val Gly Phe Asp
                165                 170                 175     
Ala Val Met Arg Val Arg Thr Ser Thr Gly Ile Arg Ala Val Asp Phe
            180                 185                 190         
Phe Gly Ala Phe Tyr Met Ser Asn Thr Thr Asp Val Glu Leu Ala Gly
        195                 200                 205             
Leu Asp Gly Asp Lys Thr Val Thr Val Glu Phe Lys His Asp Asp Arg
    210                 215                 220                 
Leu Asn Glu Glu Ser Gly Ala Leu Leu Gln Cys Ala Leu Leu Tyr Thr
225                 230                 235                 240 
Ser Cys Ala Gly Gln Arg Arg Leu Arg Ile His Asn Leu Ala Leu Asn
                245                 250                 255     
Cys Cys Thr Gln Leu Ala Asp Leu Tyr Arg Asn Cys Glu Thr Asp Thr
            260                 265                 270         
Leu Ile Asn Tyr Met Ala Lys Phe Ala Tyr Arg Gly Val Leu Asn Ser
        275                 280                 285             
Pro Val Lys Ala Val Arg Asp Thr Leu Ile Thr Gln Cys Ala Gln Ile
    290                 295                 300                 
Leu Ala Cys Tyr Arg Lys Asn Cys Ala Ser Pro Ser Ser Ala Gly Gln
305                 310                 315                 320 
Leu Ile Leu Pro Glu Cys Met Lys Leu Leu Pro Val Tyr Leu Asn Cys
                325                 330                 335     
Val Leu Lys Ser Asp Val Leu Gln Pro Gly Ala Glu Val Thr Thr Asp
            340                 345                 350         
Asp Arg Ala Tyr Val Arg Gln Leu Val Thr Ser Met Asp Val Thr Glu
        355                 360                 365             
Thr Asn Val Phe Phe Tyr Pro Arg Leu Leu Pro Leu Thr Lys Ser Pro
    370                 375                 380                 
Val Glu Ser Thr Thr Glu Pro Pro Ala Val Arg Ala Ser Glu Glu Arg
385                 390                 395                 400 
Leu Ser Asn Gly Asp Ile Tyr Leu Leu Glu Asn Gly Leu Asn Leu Phe
                405                 410                 415     
Leu Trp Val Gly Ala Ser Val Gln Gln Gly Val Val Gln Ser Leu Phe
            420                 425                 430         
Ser Val Ser Ser Phe Ser Gln Ile Thr Ser Gly Leu Ser Val Leu Pro
        435                 440                 445             
Val Leu Asp Asn Pro Leu Ser Lys Lys Val Arg Gly Leu Ile Asp Ser
    450                 455                 460                 
Leu Arg Ala Gln Arg Ser Arg Tyr Met Lys Leu Thr Val Val Lys Gln
465                 470                 475                 480 
Glu Asp Lys Met Glu Met Leu Phe Lys His Phe Leu Val Glu Asp Lys
                485                 490                 495     
Ser Leu Ser Gly Gly Ala Ser Tyr Val Asp Phe Leu Cys His Met His
            500                 505                 510         
Lys Glu Ile Arg Gln Leu Leu Ser
        515                 520 


<210> 2826
<211> 97
<212> PRT
<213> Homo sapiens

<400> 2826
Met Pro Ser Ile Val Met Ala Thr Ala Val Tyr His Arg Asp Asp Val
 1               5                  10                  15      
Leu Asn Gln Gly Ser Gly Val Glu Asp Val Asp Leu Gly Glu Pro Leu
            20                  25                  30          
Val Gly Val Leu Lys Ala Ser Trp Phe Gln Ser Gly Gln Val Pro Ser
        35                  40                  45              
Pro Asn Thr Gly Leu Arg Pro Lys Thr Lys Ile Gln Gly Leu Arg Leu
    50                  55                  60                  
Thr Leu Ala Leu Ser Pro Arg Leu Glu Cys Ser Gly Val Ile Ser Ala
65                  70                  75                  80  
His Ser Asn Leu Asp Leu Pro Gly Ser Ser Asn Ser Pro Ala Ser Ala
                85                  90                  95      
Ala
    


<210> 2827
<211> 291
<212> PRT
<213> Homo sapiens

<400> 2827
Met Gly Met Gly Leu Lys Glu Pro Ser Glu Ser Gln Cys Gln Gly Val
 1               5                  10                  15      
Val Glu Leu Glu Arg Pro Val Leu Ser Cys His Gly Ala Gly Trp Ser
            20                  25                  30          
His Leu Lys Gln Arg Glu Trp Glu Gln His Ser Leu Ala Trp His Leu
        35                  40                  45              
Arg Leu Ser Leu Trp Leu Pro Trp Ala Met Ala Leu Pro Ala Val Ser
    50                  55                  60                  
Ile Lys Pro Arg Gln Lys Thr Pro Thr Ser Gln Phe Asn Ser Gly Val
65                  70                  75                  80  
Pro Arg Arg Cys Pro Ile Ala Arg Gly Lys Ala Leu Pro Trp Pro Ala
                85                  90                  95      
Gly Gly Thr Pro Gln Arg Cys Pro Ile Leu Gly Asp Leu Pro Leu Lys
            100                 105                 110         
Gln Pro Ser Gly Ser Pro Cys Gly Ser Thr Gly Ser Ser Glu Asp Pro
        115                 120                 125             
Ser Ser Ser Arg Gln Glu Pro Leu Ile Leu Pro Thr Asn Gly Ile Glu
    130                 135                 140                 
Ala Gln Ser Asp Arg Thr Ala Ala Gln Gly His Ala Trp Ala Glu His
145                 150                 155                 160 
Lys Ala Ala Pro Leu Pro Cys Trp Asn Pro Ser His Trp Ala Gly Leu
                165                 170                 175     
Cys Ser Ala Leu Leu Thr Pro Thr Gly Leu His Ser Ala Thr Asn Ala
            180                 185                 190         
Tyr Glu Gly Leu Pro Gln Leu Cys Tyr Gly Ser Met His Gln Glu His
        195                 200                 205             
Asn Gln Asn Thr Ala Val Phe Trp Ala Ala Glu Gln Ala Arg Thr Gly
    210                 215                 220                 
Ile His Gln Val Cys Leu Gly Lys Pro Arg Lys Asn Gly Gln Gln Trp
225                 230                 235                 240 
Asp His Cys Trp Ala Gln Leu Gln Ser Lys Asn Asp Phe Arg Gln Asp
                245                 250                 255     
Ala Val Lys Gly Pro Glu Pro Ser Arg Asp Glu Gly Phe Ala Phe Val
            260                 265                 270         
Cys Leu Gln Ile Ser Gly Trp Gly Ile Lys Asn Arg Thr Gln Glu Cys
        275                 280                 285             
His Pro Arg
    290     


<210> 2828
<211> 672
<212> PRT
<213> Homo sapiens

<400> 2828
Met Ile Glu Gln His Asn Gln Glu Tyr Ser Gln Gly Lys His Ser Phe
 1               5                  10                  15      
Thr Met Ala Met Asn Ala Phe Gly Asp Met Thr Asn Glu Glu Phe Arg
            20                  25                  30          
Gln Val Met Asn Gly Phe Gln Tyr Gln Lys His Arg Lys Gly Lys Gln
        35                  40                  45              
Phe Gln Glu Arg Leu Leu Leu Glu Ile Pro Thr Ser Val Asp Trp Arg
    50                  55                  60                  
Glu Lys Gly Tyr Met Thr Pro Val Lys Asp Gln Gly Gln Cys Gly Ser
65                  70                  75                  80  
Cys Trp Ala Phe Ser Ala Thr Gly Ala Leu Glu Gly Gln Met Phe Trp
                85                  90                  95      
Lys Thr Gly Lys Leu Ile Ser Leu Asn Glu Gln Asn Leu Val Asp Cys
            100                 105                 110         
Ser Gly Pro Gln Gly Asn Glu Gly Cys Asn Gly Asp Phe Met Asp Asn
        115                 120                 125             
Pro Phe Arg Tyr Val Gln Glu Asn Gly Gly Leu Asp Ser Glu Ala Ser
    130                 135                 140                 
Tyr Pro Tyr Glu Gly Lys Val Lys Thr Cys Arg Tyr Asn Pro Lys Tyr
145                 150                 155                 160 
Ser Ala Ala Asn Asp Thr Gly Phe Val Asp Ile Pro Ser Arg Glu Lys
                165                 170                 175     
Asp Leu Ala Lys Ala Val Ala Thr Val Gly Pro Ile Ser Val Ala Val
            180                 185                 190         
Gly Ala Ser His Val Phe Phe Gln Phe Tyr Lys Lys Gly Ile Tyr Phe
        195                 200                 205             
Glu Pro Arg Cys Asp Pro Glu Gly Leu Asp His Ala Met Leu Val Val
    210                 215                 220                 
Gly Tyr Ser Tyr Glu Gly Ala Asp Ser Asp Asn Asn Lys Tyr Trp Leu
225                 230                 235                 240 
Val Lys Asn Ser Trp Gly Lys Asn Trp Gly Met Asp Gly Tyr Ile Lys
                245                 250                 255     
Met Ala Lys Asp Arg Arg Asn Asn Cys Gly Ile Ala Thr Ala Ala Ser
            260                 265                 270         
Tyr Pro Thr Val Leu Ser Pro Lys Ala Gln Leu Gln Ser Leu Gln Ile
        275                 280                 285             
Thr Pro Glu Ser Lys Phe Leu Arg Gln Leu Trp Gly Ser Ala Arg Gly
    290                 295                 300                 
Leu Val Val Ala Ala Val Val Val Pro Phe Pro Ile Ala Gln Ser Val
305                 310                 315                 320 
Leu Glu Glu Asp Val Ala Glu Thr Leu Leu His Lys Leu Glu Val Pro
                325                 330                 335     
Gly Gly Ala Pro Met Gly Arg Leu Gly Lys Thr Gly Ala Leu Gly Thr
            340                 345                 350         
Glu Ala Phe His Cys Cys Pro Ser Gly Gly Pro Lys Cys Gly Leu Arg
        355                 360                 365             
Gly Gly Pro Gly Glu Tyr Glu Cys Ser Gln Ala Asp Gly Lys Cys Asn
    370                 375                 380                 
Arg Lys Arg Ser Gly Gln Thr Ser Glu Asn Val Gly Glu Leu Pro Gln
385                 390                 395                 400 
Arg Trp Lys Pro Gly Thr Arg Asp Ser Trp Cys Leu Thr Glu Gly Ala
                405                 410                 415     
His His His Ser Pro Arg Pro Arg Ala Phe Pro Gln Gly Ala Leu Arg
            420                 425                 430         
Arg Ala Arg Phe Gln Arg Glu Ala Gly Arg Pro Gln Pro Leu Pro Ala
        435                 440                 445             
Pro Val Ala Ala Val Asp Gly Arg Glu Thr Arg Ser Ala Arg Ala Lys
    450                 455                 460                 
Gly Gly Asp Pro Thr Ala Phe Ala Leu Met Ala Ser Phe Leu Val Leu
465                 470                 475                 480 
Pro Lys Asn Lys Ala Lys Gly Asp Gln Lys Pro Gly Thr Leu Ala Phe
                485                 490                 495     
Ser Arg Leu Ser Pro Asp Val Ser Leu Tyr Ser Ser Cys Leu Lys Leu
            500                 505                 510         
Gly Pro Thr Asn Gly Arg Gln Arg Pro Lys Phe Asn Pro Val Lys Pro
        515                 520                 525             
Ala Pro Ala Asn Lys Ala His Gly Trp Arg Pro Arg Asp Ser Ser Gly
    530                 535                 540                 
Pro Ala Leu Arg Leu Ser Pro Asp Leu Tyr Gly Phe Arg Gly Ser Leu
545                 550                 555                 560 
Glu Gly Gln Asn His Ile Pro Ala Ala Val Ser Phe Asp Ala Leu Arg
                565                 570                 575     
Lys Leu Gln Arg Pro Lys Leu Phe Pro Glu Lys Arg Ser Phe Thr Gly
            580                 585                 590         
Val Pro Ala Leu Ser Ile Asp Phe Thr Asn Gly Cys Asp Leu Val Gly
        595                 600                 605             
Ser Ser Ser Leu His Asn Met Leu Val Cys Ser Ser Tyr Asp Ile Asn
    610                 615                 620                 
Arg Gln Asp Thr Phe Gln Lys Asp Arg Lys Ile Thr Asp Gln Arg Pro
625                 630                 635                 640 
Pro Leu Ala Gly Glu Pro Gly Arg Ala Ala Gly Glu Ile Gly Val Leu
                645                 650                 655     
Pro His Cys Arg Ser Ser Gln Gly Leu Arg Glu Gly Thr Gly Asn Trp
            660                 665                 670         


<210> 2829
<211> 103
<212> PRT
<213> Homo sapiens

<400> 2829
Met Leu Leu Leu Tyr Gln Leu Ile Ser Phe Ser Met Tyr Ser Arg Ser
 1               5                  10                  15      
Leu Arg Ser Ile Val Arg Arg Val Ser Ile Ile Asn Ala Gly Leu Lys
            20                  25                  30          
Phe Ser Val Glu Thr Val Thr Ser Gly Lys Leu Ser Asp Cys Pro Gln
        35                  40                  45              
Gly Leu Ala Gly Gly Arg Leu Arg Ala Ser Lys Pro Glu Val Val Ile
    50                  55                  60                  
Thr Asn Ser Ser Phe Thr Glu Arg Trp Leu Phe Leu Val Leu Ser Leu
65                  70                  75                  80  
Tyr Ile Ser Ala Tyr Val Val Gly Arg Asn Ser Val Ser Gln Lys Met
                85                  90                  95      
Ser Thr Trp Asn Leu Gly Met
            100             


<210> 2830
<211> 294
<212> PRT
<213> Homo sapiens

<400> 2830
Met Met Glu Val Leu Lys Asn Asn Asn Arg Glu Ile Asp His Gly Gln
 1               5                  10                  15      
Ser Leu Glu Pro Ser Arg Glu Arg Arg Trp Ala Pro Glu Ala Glu Glu
            20                  25                  30          
Asp Val Glu Gly Asn Gly Glu Trp Val Lys Tyr Ile Asp Asp Gly Asp
        35                  40                  45              
His Pro Arg Ala Val Ala Ile Ala Lys Leu Arg Arg Arg Arg Val Trp
    50                  55                  60                  
Arg Gly Cys Gln Phe Leu Arg Val Thr Ile Glu Glu Arg Val Glu Met
65                  70                  75                  80  
Glu Phe Arg Ser Arg Ser His Arg Ser Glu Cys Asp Ile Val Leu Lys
                85                  90                  95      
Arg Pro Ser Phe Gln Ile Leu Leu Leu Gly Val Ala Asp Gly Val Ile
            100                 105                 110         
Val Thr Leu Glu Met His Leu Val Gly Arg Glu Arg Val Ser Asp Thr
        115                 120                 125             
Arg Lys Arg Ile Ser Asp Gln Ser Ser Gln Met Phe Thr Ala Thr Asn
    130                 135                 140                 
Gly Leu Arg Ser Gln Arg Glu Arg Glu Gly Pro Gln Asp Gly Thr Gly
145                 150                 155                 160 
Gln Pro Gly Glu Lys Thr Asn Phe Leu Thr Gln Ser Leu Ala Glu Leu
                165                 170                 175     
Asp Thr Leu Cys Leu Ser His Arg Thr Thr Ser Tyr Cys Met Glu Val
            180                 185                 190         
Asp Glu Lys Val Asn Arg Glu Gln Ala Thr Pro Lys Ser Arg Ala Pro
        195                 200                 205             
Lys Ala Pro Ala Gly Gln His Phe Ser Ile Ile Ser Asn Ile Ser Ile
    210                 215                 220                 
Gly Val Pro Glu Lys Ala Gly Thr Ser Val Leu Asn Pro Gln Thr Thr
225                 230                 235                 240 
Ile Trp Ser Arg Met Val Tyr Gln Val Glu Glu Asp Val Asp Val Ile
                245                 250                 255     
Tyr Asp Gly Phe Glu Asn Ser Asp Ser Ser Glu Phe Gly Glu Leu Thr
            260                 265                 270         
Ser Lys Ala Ala Arg Tyr Leu Ser Arg Glu Ser Ala Gly Lys Leu Ser
        275                 280                 285             
Val Gly Leu Val Ser Gln
    290                 


<210> 2831
<211> 137
<212> PRT
<213> Homo sapiens

<400> 2831
Met Met Ile Asp Leu Ala Glu Val Ala Asp Leu Val Leu Met Leu Ile
 1               5                  10                  15      
Asp Ala Ser Phe Gly Phe Glu Met Glu Met Phe Glu Phe Leu Asn Ile
            20                  25                  30          
Cys Gln Ala His Gly Phe Pro Lys Ile Leu Gly Val Leu Thr His Leu
        35                  40                  45              
Asp Ser Phe Lys His Asn Lys Gln Leu Lys Lys Thr Lys Lys Arg Leu
    50                  55                  60                  
Lys His Arg Phe Trp Thr Glu Val Tyr Gln Val Ala Lys Leu Phe Tyr
65                  70                  75                  80  
Leu Ser Gly Met Val His Gly Glu Tyr Gln Asn Gln Glu Ile His Asn
                85                  90                  95      
Leu Gly His Phe Ile Thr Val Met Lys Phe Arg Pro Leu Met Ala Asn
            100                 105                 110         
Phe Ser Pro Leu Tyr Pro Gly Arg Gln Asp Gly Arg Phe Asp Lys Pro
        115                 120                 125             
Gly Gly Tyr Pro Asn Lys His Gln Met
    130                 135         


<210> 2832
<211> 239
<212> PRT
<213> Homo sapiens

<400> 2832
Met Gly Pro Ala Lys Thr Ser Ala Ser Leu Gly Asn Gln Glu Ala Leu
 1               5                  10                  15      
Pro Thr Arg Arg His Met Ala Gly Ala Glu Lys Ser His Glu Gly Cys
            20                  25                  30          
Ser Leu Val Ser Ala Asn Asp Lys His Ser Thr Thr Gly Gly Gln Arg
        35                  40                  45              
Pro Arg Pro Val Asp Leu Arg Ser Glu Lys His Arg Thr Glu Lys His
    50                  55                  60                  
Gln Asn Thr Glu Thr Leu Lys Gln Arg Asn Thr Glu Thr Glu Lys His
65                  70                  75                  80  
Gln Thr Glu Lys His Arg Asn Arg Glu Thr Pro Asn Arg Glu Thr Pro
                85                  90                  95      
Lys Gln Arg Lys Gly Ser Ala Pro Asp Ser Gly Leu Pro Arg Pro Met
            100                 105                 110         
Arg His Cys Leu Ala Leu Lys Pro Val Thr Ile Pro Ala Val Gly Arg
        115                 120                 125             
Arg Ile Asp Arg Gln Ala Leu Gln Pro Gln Ala Ser Arg Val Thr Glu
    130                 135                 140                 
Leu Glu Ala Val Trp Leu Leu Pro Gly Ala Gly Thr Gly Ala Ser Gly
145                 150                 155                 160 
Ile Leu Glu Val Gln Leu Gln Ala Val Gly Pro Leu Ser Pro Ser Arg
                165                 170                 175     
Cys Arg Glu Ala Gln Glu Leu Val Thr Val Gln Glu Val Leu Thr Pro
            180                 185                 190         
Arg Ala Gly Asn Gly Ala Gln Gln Glu Pro Ala Gly Pro Asp Gly His
        195                 200                 205             
Arg Arg Lys Asp Ser Lys Arg Trp Asp Gly Gly Leu Gly Glu Gly Ala
    210                 215                 220                 
Ala Gly Gly Thr Glu Pro Gly Pro Ser Gly Gln Gly Gly His Arg
225                 230                 235                 


<210> 2833
<211> 39
<212> PRT
<213> Homo sapiens

<400> 2833
Met Ala Arg Lys Leu Arg Ser Ala Ser Trp Lys Gly Trp Phe Thr Leu
 1               5                  10                  15      
Arg Ala Gly Val Lys Ala Glu Ser Thr Gly Pro Ser Asn Lys Cys Pro
            20                  25                  30          
Ala Leu Val Ser Gly Pro Ile
        35                  


<210> 2834
<211> 239
<212> PRT
<213> Homo sapiens

<400> 2834
Met His Ser Thr Ser Glu Lys Leu Leu Leu Ser Ala Ile Leu Ala Ile
 1               5                  10                  15      
Ile Phe Cys Gly Ile Cys Cys His Lys Tyr Met Lys Val Asn Ile Ser
            20                  25                  30          
Glu Gln Ser Ala Thr Thr Met His Tyr Thr Met Lys Met Leu Ala Ser
        35                  40                  45              
Gly Thr Asn Thr Ile Phe Ile Ser Leu Gly Ile Ser Thr Met Asn Leu
    50                  55                  60                  
Leu Ile Trp Thr Trp Asn Met Ala Phe Ile Leu Leu His Trp Pro Ser
65                  70                  75                  80  
Pro Ser Cys Thr Glu Pro Trp Cys His Pro Val Leu Thr Pro Val Leu
                85                  90                  95      
Leu Leu Asp Asp Ala Ala Gly Asp His Arg Pro Gly Leu His Gly Ala
            100                 105                 110         
Met Ala Phe Ile Leu Val Val Leu Pro Asp Arg Asn Lys Val Lys Glu
        115                 120                 125             
Lys Asn Leu Phe Val Ser Thr Thr Val Ile Val Phe Phe Thr Val Ile
    130                 135                 140                 
Phe Arg Gly Leu Pro Ile Lys Ser Leu Val Gln Trp Leu Lys Val Lys
145                 150                 155                 160 
Arg Ser Glu His Gln Glu Pro Lys Leu His Glu Lys Leu His His His
                165                 170                 175     
Ala Phe Asn His Ile Leu Leu Ala Ile Lys Asp Ile Ser Arg His Ile
            180                 185                 190         
Arg His Asn Tyr Leu Arg Glu Met Trp Ser His Phe Asp Arg Lys Phe
        195                 200                 205             
Leu Ser Gly Val Leu Met Arg Arg Leu Thr Gln Lys Ser Arg Asp Glu
    210                 215                 220                 
Ile Leu Asn Val Phe His Glu Leu Asn Leu Lys Asp Val Ile Ser
225                 230                 235                 


<210> 2835
<211> 424
<212> PRT
<213> Homo sapiens

<400> 2835
Met Glu Asp Trp Glu Asn Ser Lys Ala Phe Gln Gln Gly Leu Ser Gln
 1               5                  10                  15      
Thr Tyr Ser Ser Ala Pro Phe Asn Ala Ala Leu Leu Asn Pro Glu Arg
            20                  25                  30          
Lys Ala Ala Phe Thr Arg Thr Leu Gln Ala Glu Ser Val Ser Trp Thr
        35                  40                  45              
Arg Ala Leu Tyr Pro Ala His Gly Arg Thr Pro Gln Ala Arg Val Arg
    50                  55                  60                  
Val Lys Thr Val Gly Glu Ala Ala Ala Ala Ala Ala Val Leu Pro Leu
65                  70                  75                  80  
Thr Arg Arg Trp Gly Ile Ala Gln Thr Pro Ser Val Thr Glu Lys Arg
                85                  90                  95      
Arg Pro Gly Glu Thr Val Gln Phe Trp Ala Ala Pro Ile Pro Leu Gln
            100                 105                 110         
Ala Leu Pro Leu Asn Val Pro Ala Pro Arg Gly Gln Pro Cys Gly Val
        115                 120                 125             
Ser Glu Pro Pro Ala Ser Leu Ala Gly Cys Tyr Ala Ala Trp Arg Glu
    130                 135                 140                 
Gly Glu Arg Ser Ser Gly Arg Gly Gly Pro Thr Cys Phe Val Val Arg
145                 150                 155                 160 
Gly His Arg Gly Ala Thr Val Gly Gly Ser Arg Asn Ser Gly Arg Leu
                165                 170                 175     
Ala Gly Cys Asp Leu Asp Arg Arg Cys Pro Ile Gly Pro Arg Asn Arg
            180                 185                 190         
Glu Ala Gly Cys Leu Ser Leu Pro His Asp Ser Leu Ala Leu Glu Ser
        195                 200                 205             
Arg Gln Pro Pro Glu Phe Arg Ser Arg Ser Pro Arg Arg Gly Met Lys
    210                 215                 220                 
Ser Gly Ala Gly Gln Arg Arg Gly Ser Ala Pro Gln Ser Arg Ser Pro
225                 230                 235                 240 
Thr Gly Ser Leu Gly Ala Arg Gly Glu Gln Ser Ala Gln Ala Gly Pro
                245                 250                 255     
Ser His Ser Arg Pro Ala Arg Arg Leu Pro Pro Ala Ala Ala Ala Pro
            260                 265                 270         
Leu Ala Ala Arg Gly Arg Ala Ser Arg Gly Val Gly Asp Leu Ala Ser
        275                 280                 285             
Gly Gly Arg Gly Ala Ala Thr Gly Pro Ala Tyr His Val Thr Val Arg
    290                 295                 300                 
Gly Ala Pro Gly Ser His Leu Pro Pro Gly His Arg Ala Ala Gly Ala
305                 310                 315                 320 
Arg Asn Arg Pro Gly Ser Trp Arg Asp Arg Pro Pro Pro Pro Arg Pro
                325                 330                 335     
Pro Ile Gly Leu Trp Ala Pro Asp Ser Gly His Arg Ser Ala Pro Ala
            340                 345                 350         
Ser Ala Ser Pro Trp Gly Ile Gly Val Leu Tyr Arg Pro Leu Ala Cys
        355                 360                 365             
Pro Glu Asp Arg Phe Ser Pro Gly Pro Glu Ala Asn Cys Gly Glu Ile
    370                 375                 380                 
Glu Thr Thr Glu Leu Arg Trp Arg Arg Val Pro Ala Phe Pro Gln Arg
385                 390                 395                 400 
Arg Lys Leu Ala Arg Glu Ser Ser Ser Val Ile Gln Arg Glu Arg Cys
                405                 410                 415     
Ser Gly Cys Leu Pro Val Leu Thr
            420                 


<210> 2836
<211> 597
<212> PRT
<213> Homo sapiens

<400> 2836
Met Glu Cys Pro Glu Met Asn Cys Glu Glu Gly Trp Ala Leu Ala Lys
 1               5                  10                  15      
Cys Gly Gly Lys Asn Tyr Glu Gln Ala Lys Ala Cys Phe Glu Lys Ala
            20                  25                  30          
Leu Glu Val Gly Pro Glu Asn Pro Glu Phe Ser Thr Gly Tyr Val Ile
        35                  40                  45              
Thr Ala Tyr Cys Leu Asp Gly Phe Asn Thr Thr Asp Ser Asn Glu Thr
    50                  55                  60                  
Phe Ser Leu His Pro Leu Lys Trp Ala Val Ser Leu Asn Pro Lys Asp
65                  70                  75                  80  
Ala His Ile Lys Val Ile Leu Ala Leu Lys Leu Gln Asp Glu Gly Gln
                85                  90                  95      
Glu Ala Glu Gly Glu Lys His Thr Glu Lys Ala Leu Ile Lys Gln Arg
            100                 105                 110         
Pro Thr Phe Ala Met Val Tyr Val Asp Leu Ala Asn Ser Glu Glu Ser
        115                 120                 125             
Asp Gly Lys Leu Ile Glu Asp Ser Leu Ile Gln Leu Arg Cys His Phe
    130                 135                 140                 
Thr Trp Lys Leu Leu Ile Glu Ala Pro Glu Ile Pro Asp Leu Glu Asn
145                 150                 155                 160 
Arg Ile Trp Glu Glu Ile Gln Phe Leu Asp Thr Lys Tyr Asn Val Gly
                165                 170                 175     
Ile His Asn Leu Leu Ala Tyr Val Lys His Leu Lys Gly Gln Asn Glu
            180                 185                 190         
Glu Ala Leu Val Ser Leu Lys Lys Ala Glu Asp Leu Ile Gln Lys Glu
        195                 200                 205             
His Ala Asn Gln Ala Asp Ile Arg Ser Leu Val Thr Trp Gly Asn Phe
    210                 215                 220                 
Ala Trp Val Tyr Tyr His Met Gly Arg Leu Ala Glu Ala Gln Thr Tyr
225                 230                 235                 240 
Leu Asp Lys Val Glu Asn Thr Cys Lys Lys Phe Ala Asn Pro Ser Arg
                245                 250                 255     
Tyr Arg Met Glu Cys Pro Glu Val Asp Cys Glu Glu Gly Trp Ala Leu
            260                 265                 270         
Ala Lys Cys Gly Gly Lys Asn Tyr Glu Arg Ala Lys Thr Cys Phe Glu
        275                 280                 285             
Lys Ala Leu Glu Gly Asn Pro Glu Asn Pro Glu Phe Asn Thr Gly Tyr
    290                 295                 300                 
Ala Ile Thr Val Tyr Arg Leu Asp Lys Phe Asn Thr Ala Ser Gly Arg
305                 310                 315                 320 
Asn Lys Ala Phe Ser Leu His Val Leu Lys Arg Ala Val Arg Leu Asn
                325                 330                 335     
Pro Asp Asp Val Tyr Ile Arg Val Leu Leu Ala Leu Lys Leu Gln Asp
            340                 345                 350         
Glu Gly Gln Glu Ala Glu Gly Glu Lys Tyr Ile Glu Glu Ala Leu Thr
        355                 360                 365             
Ser Ile Ser Ser Gln Ala Tyr Val Phe Gln Tyr Ala Ala Lys Phe Tyr
    370                 375                 380                 
Arg Arg Lys Gly Ser Val Asp Lys Ala Leu Glu Leu Leu Lys Met Ala
385                 390                 395                 400 
Leu Glu Thr Thr Pro Thr Ser Ala Phe Leu His His Gln Met Gly Leu
                405                 410                 415     
Cys Tyr Arg Ala Gln Met Ile Gln Ile Lys Glu Ala Thr Asn Trp Gln
            420                 425                 430         
Pro Arg Gly Gln Asp Arg Glu Thr Val Asp Arg Leu Val Gln Leu Ala
        435                 440                 445             
Ile Cys Lys Phe Glu Lys Thr Ile Met Leu Lys Arg Thr Phe Glu Met
    450                 455                 460                 
Ala Tyr Val Asp Leu Ala Glu Thr Tyr Ala Glu Ile Gly His His Arg
465                 470                 475                 480 
Lys Ala Glu Glu His Phe Gln Lys Gly Leu Arg Met Lys Ile Phe Glu
                485                 490                 495     
Asp Gln Leu Lys Gln Glu Ile His Tyr His Tyr Gly Arg Phe Gln Glu
            500                 505                 510         
His His Gly Lys Ser Gln Asp Lys Ala Ile Thr His Tyr Leu Lys Gly
        515                 520                 525             
Leu Lys Ile Glu Lys Met Ser His Ser Arg Glu Lys Leu Leu Asn Ala
    530                 535                 540                 
Leu Glu Lys Leu Ala Lys Arg Cys Ile His Gln Asn Val Arg Val Val
545                 550                 555                 560 
Glu Ser Val Ser Leu Leu Gly Leu Ile His Lys Leu Lys Gly Glu Val
                565                 570                 575     
Ser Asp Ala Leu Leu Cys Tyr Glu Arg Ala Leu Arg Leu Ala Ala Asp
            580                 585                 590         
Leu Asn Pro Ile Phe
        595         


<210> 2837
<211> 168
<212> PRT
<213> Homo sapiens

<400> 2837
Met Glu Ala Glu Asp Arg Gly Ala Pro Leu Cys Val Tyr Ala Leu Tyr
 1               5                  10                  15      
Leu Pro Pro Ser Gly Thr Ser Pro Gly Ser Phe Ile Lys Gly Leu Arg
            20                  25                  30          
Gln Leu Cys Ser Ser Pro Ala Ala Ala Pro Leu Ala Leu Arg Lys Asp
        35                  40                  45              
Ile Arg Asn Arg Gln Pro Arg Leu Ile Val Ala Arg Leu Arg Gly Arg
    50                  55                  60                  
Glu Met Ser Pro Asp Thr Ala Ala Ala Ala Leu Ala Ser Arg Glu Pro
65                  70                  75                  80  
Thr Arg His Gly Leu Gly Ala Pro Pro Ala Ala Ala Val Ala Pro Leu
                85                  90                  95      
Arg Leu Pro Phe Phe Ser Ser Tyr His Ser Pro Ala His Leu Arg Leu
            100                 105                 110         
Ser Gly Glu Ser Ser Asn Gly Ile Ala Ser Val Ser Val Leu Cys Cys
        115                 120                 125             
Val Ala Asp Leu Gly Ala Leu Glu Gly Lys Ser Trp His Phe Gly Glu
    130                 135                 140                 
Glu Gly Leu Ala Leu Ser Arg Arg Leu Leu Gln Leu Ser Cys Cys Leu
145                 150                 155                 160 
Asp Leu Arg Thr Ser Asn Leu Lys
                165             


<210> 2838
<211> 134
<212> PRT
<213> Homo sapiens

<400> 2838
Met Pro Gln Met Pro Leu Pro Val Ser Ser Trp Glu Ser Pro Leu Phe
 1               5                  10                  15      
Leu Pro Leu Leu Ala Tyr Ala Thr Leu Cys Thr Ala Val Asp Lys Gly
            20                  25                  30          
Met Pro Ser Leu Ala Gly Leu Pro Ser Pro Gly Ser Pro Pro Thr Arg
        35                  40                  45              
Ala Leu Arg Ala Ser Ala Gly Ser Thr Gly Gln Gly Arg Arg Leu Ser
    50                  55                  60                  
Gly Ser Leu Trp Tyr Asp Glu Leu Val Cys Lys Gln Arg Ala His Leu
65                  70                  75                  80  
Leu Asn Ile Arg Gly His Phe Pro Leu Arg Glu Gly Pro Gly Ala Gly
                85                  90                  95      
Leu Gln Phe Gln Ala Gln Arg Ser Ser Leu Leu Pro Gln Glu Leu Ala
            100                 105                 110         
Gln Ser Pro Ser Ala Leu Cys Pro Ile Ser Ser Met Gln Lys Asp Ile
        115                 120                 125             
Glu Pro His Gly Thr Met
    130                 


<210> 2839
<211> 264
<212> PRT
<213> Homo sapiens

<400> 2839
Met Lys Asp Gln Glu Ser Tyr Val Phe Leu Pro Leu Asn Arg Glu Arg
 1               5                  10                  15      
Val Met Ser Glu Ile Ile Phe Asn Ala Gly Tyr Met Asp Cys Lys Ala
            20                  25                  30          
Thr Ala Ser Tyr Ala Leu Glu Ala Glu Gly Asp Lys Ala Arg Ser Asn
        35                  40                  45              
Asn Asp Ser Gly Asn Ile Ile Leu Ser Asp Gln Ala Arg Asn Phe Arg
    50                  55                  60                  
Arg Ile Pro His Tyr Val Met Ser Glu Glu Glu Asn Ile Lys Pro Ala
65                  70                  75                  80  
Ile Leu Val Thr Trp Thr Leu Ala Thr Val Ile Ile Gln Val Ser Pro
                85                  90                  95      
Ala Cys Leu Ile Val Leu Gln Cys Leu Gln Asp Glu Val Gln Met Ala
            100                 105                 110         
Leu Phe Gln Tyr Gly Ser Leu Asp Val Val Ile Leu Ile Leu His Leu
        115                 120                 125             
Ile Thr Val Leu Asp Asp Cys Gln Lys Ser Leu Leu Ser Tyr Ser Ala
    130                 135                 140                 
Pro Gln Leu Leu Gln Ser Ala Ile Phe Phe Arg Asp Leu Pro Asp Phe
145                 150                 155                 160 
Ala Ser Leu Leu Leu Thr Ala Lys Asn Phe Lys Pro Phe Ala Val Ala
                165                 170                 175     
Ala Lys Arg Glu Ala Phe Asp Val Lys Val Ser Gly Leu Asn Cys Gly
            180                 185                 190         
Ala Ala Leu Gly Ser Val Leu Leu Leu Ser Gln Ala Pro Leu Gln Leu
        195                 200                 205             
Ala Val Met Leu His Ser Thr Met Met Ser Asn Arg Arg Cys Lys Glu
    210                 215                 220                 
Asn Arg Asp Leu Lys Val Gln Arg Leu Phe Gln Gln Asp Arg Gly Asn
225                 230                 235                 240 
Arg Gly Ser Gly Gln Met Cys Ser Gly Asp Cys Gln Ser Val Ser Gln
                245                 250                 255     
Cys Pro His Leu Glu Val Thr Asn
            260                 


<210> 2840
<211> 172
<212> PRT
<213> Homo sapiens

<400> 2840
Met Ala Ser Ser Gln Val Ala Ser Ser Glu Val Pro Thr Pro Leu Gln
 1               5                  10                  15      
Leu Ala Ala Leu Ala His Ser Pro Tyr Arg Pro Val Leu Trp Ala Ala
            20                  25                  30          
His Val Leu Ser Thr Leu Ala Ala Leu Arg Cys Pro Gln Glu Leu Gly
        35                  40                  45              
Leu Gly Pro Gly Asp Thr Gly His Leu Gly Ala Gly Arg Gln Glu Ala
    50                  55                  60                  
Thr Gly Glu Thr Arg Pro Val Asp Thr Gly Leu Leu Pro Pro Ala Pro
65                  70                  75                  80  
Gly Gln His Pro Gly Val Glu Arg Ala Ser Gly Leu Cys Ser Glu Gly
                85                  90                  95      
Phe Ser Val Cys Phe His His Val Ser His Ser Ala Gln Asp Lys Ser
            100                 105                 110         
Thr Lys Leu Thr Ser Leu Leu Ser Phe Arg Arg Cys Glu Ala Gln Glu
        115                 120                 125             
Gly Ser Ser Ala Gly Leu Thr Ala Lys Arg Gly Tyr Ala Ser Cys Arg
    130                 135                 140                 
Gln Val Gln Ser Asn Asp Gly Ile Met Gly Phe Asn Ala Leu Gly Phe
145                 150                 155                 160 
Ser Arg Asp Leu Ser Phe Ile Pro Asn Lys Thr Asn
                165                 170         


<210> 2841
<211> 297
<212> PRT
<213> Homo sapiens

<400> 2841
Met Asp Leu Lys Leu Phe Met Lys Glu Phe Ser Ala Ser Arg Gln Ala
 1               5                  10                  15      
Ser Leu Lys Val Thr Ser Pro Val Ala Ala Met His Trp Gly Ile Gln
            20                  25                  30          
Gly Met Lys Glu Thr Arg Arg Arg Val Lys Thr Gly Thr Ala His Ala
        35                  40                  45              
Ser Pro Leu Pro Pro Arg Pro Cys Ala Ser Ser Arg Thr Gly Ser Thr
    50                  55                  60                  
Asp Ala Arg Gln Ala Gly Asp Gly Val Ser Gly Thr Arg Leu Arg Val
65                  70                  75                  80  
Arg Pro Trp Ser Leu Lys Gly Gly Phe Trp Leu Arg Glu Ser Thr Val
                85                  90                  95      
Met Trp Phe Cys Gly Phe Pro Cys Gln Gly Asp Val Arg Met Cys Gln
            100                 105                 110         
Ile Pro Thr Pro Leu Ala Ile Thr Ala Leu Leu Leu Arg Ile Phe Ser
        115                 120                 125             
Ala Leu Gly Phe Ala Phe Gln Lys Ala Lys Thr Thr Ser Thr Val Val
    130                 135                 140                 
Glu Gly Thr Pro His Thr Leu Gly Gly Gly Gly Thr Lys Arg Asn Thr
145                 150                 155                 160 
Phe Ala Thr Pro Leu Lys Gly Glu Lys Gln Gln Gly Glu Ser Thr Gly
                165                 170                 175     
Val Arg Ser Ser Ala Pro Ser Gly Gly Glu Gly Ser Thr Ala Met Ala
            180                 185                 190         
Glu Val Ser Gly Gln Cys Pro Thr Pro Ile Thr Arg Gly Arg Gly Leu
        195                 200                 205             
Ser Ala Glu Trp Val Val Thr Ala Gly Thr Ala Gly Ala Tyr Asn Tyr
    210                 215                 220                 
Ser Gly Asn Val Gly Ser Gln Gly Gln Ala Glu Val Ala Glu Pro Glu
225                 230                 235                 240 
Ser Arg Cys Arg Gly Pro Val Asn Pro Thr Arg Ser Asn Leu Val Gly
                245                 250                 255     
Thr Leu Lys Ala Ser Ser Lys Gln Pro Cys Glu Lys Pro Ala Met Met
            260                 265                 270         
Arg Thr Pro Gln Gly His Pro Gly Lys Leu His Ser Glu Lys Thr Gly
        275                 280                 285             
Asp Ile Pro Ser Val Gly Leu Glu Gln
    290                 295         


<210> 2842
<211> 397
<212> PRT
<213> Homo sapiens

<400> 2842
Met Ala Ala Asn Lys Pro Lys Ser Cys Ser Ser Ser Ile Val Ala Thr
 1               5                  10                  15      
Thr Gly Lys Arg Ile Phe Pro Val Ile Glu Pro Ser Gly Ser Arg Ala
            20                  25                  30          
His Pro Arg Ala Arg Glu Leu Ser Asp Gln Leu Ala Trp Thr Gly Gly
        35                  40                  45              
Arg Gly Ala Val Asn Gly Arg Leu His Gln Asn Ser Leu Leu Glu Lys
    50                  55                  60                  
Ile Ser Ser Lys Lys Trp Gly Ala Ser Arg Lys Gln Gln Leu Ile Ser
65                  70                  75                  80  
Thr Ser Val Gln His Cys Thr Glu Val Asp Glu Gly Phe Ser Val His
                85                  90                  95      
Val Cys Lys Thr Lys Ser Pro Ala Val Val Glu Gly Phe Pro Asn Ala
            100                 105                 110         
Glu Pro Leu Leu Asn Leu Asn Ile Pro Arg Asp Glu Leu Ser Leu Ser
        115                 120                 125             
Gln Glu Leu Pro Leu Trp Ser Leu Pro Gln Pro Ser Asp Ser Ser Pro
    130                 135                 140                 
Arg Cys Thr Leu Lys Thr Glu Glu Leu Leu Val Ser Trp Ala Ala Asn
145                 150                 155                 160 
Ser Arg Gln His Leu Thr Phe Gln Pro Glu Gln Ala Glu Trp Arg Leu
                165                 170                 175     
Ser Ala Glu Pro Gln Leu Asp Val Asp Ser Ser Trp Pro Pro Arg Gly
            180                 185                 190         
Lys Asp Arg Glu Thr Gln Thr His Leu Leu Arg Ala Glu Gly Ala Val
        195                 200                 205             
Gly Ser Gly Glu Leu Gly Ala Pro Cys Gln Gly Phe Leu Pro Gln Ile
    210                 215                 220                 
Glu Leu Leu Glu Gly Pro Thr Asp Phe Leu Trp Ala Phe Arg His Leu
225                 230                 235                 240 
Phe Ala Phe Pro Leu Ala Phe Leu Pro Tyr Pro Gln Lys Glu Ile Phe
                245                 250                 255     
Arg Gly Ser Ser Val Val Leu Pro Leu Gln Val Leu Ser Glu Ala Leu
            260                 265                 270         
Gln Arg Asp Ser Ser Trp Val Gly Arg Gly Gly Cys Gly Cys Phe Pro
        275                 280                 285             
Val Ser Val Asn Asn Gly Arg Asn Leu Gly Lys Cys Leu Gly Glu His
    290                 295                 300                 
Leu Leu Pro Val Gly Ala Phe Arg Ser Pro Pro Gly Leu Val Pro Ser
305                 310                 315                 320 
Ser Pro Thr Ala Glu Glu Thr Glu Ala Gly Ser Arg Asp Ser Ile Leu
                325                 330                 335     
Gly Leu Thr Gln Leu Glu Glu Asp Gly Ser Lys Arg Arg Val Thr Gly
            340                 345                 350         
Ser Leu Val Val Ile Gly Asn Met Gly Arg Arg Val His Gly Lys Val
        355                 360                 365             
Ala Arg Ala Trp His Arg Cys Leu Arg Leu Arg Phe Ala Gln Val His
    370                 375                 380                 
Ala Cys Thr His Arg Gln Gly Ser Leu Ala Ser Ser Phe
385                 390                 395         


<210> 2843
<211> 1137
<212> PRT
<213> Homo sapiens

<400> 2843
Met Thr Met Thr Ala Asn Lys Asn Ser Ser Ile Thr His Gly Ala Gly
 1               5                  10                  15      
Gly Thr Lys Ala Pro Arg Gly Thr Leu Ser Arg Ser Gln Ser Val Ser
            20                  25                  30          
Pro Pro Pro Val Leu Ser Pro Pro Arg Ser Pro Ile Tyr Pro Leu Ser
        35                  40                  45              
Asp Ser Glu Thr Ser Ala Cys Arg Tyr Pro Ser His Ser Ser Ser Arg
    50                  55                  60                  
Val Leu Leu Lys Asp Arg His Pro Pro Ala Pro Ser Pro Gln Asn Pro
65                  70                  75                  80  
Gln Asp Pro Ser Pro Asp Thr Ser Pro Pro Thr Cys Pro Phe Lys Thr
                85                  90                  95      
Ala Ser Phe Gly Tyr Leu Asp Arg Ser Pro Ser Ala Cys Lys Arg Asp
            100                 105                 110         
Ala Gln Lys Glu Ser Val Gln Gly Ala Ala Gln Asp Val Ala Gly Val
        115                 120                 125             
Ala Ala Cys Leu Pro Leu Ala Gln Ser Thr Pro Phe Pro Gly Pro Ala
    130                 135                 140                 
Ala Gly Pro Arg Gly Val Leu Leu Thr Arg Thr Gly Thr Arg Ala His
145                 150                 155                 160 
Ser Leu Gly Ile Arg Glu Lys Ile Ser Ala Trp Glu Gly Arg Arg Glu
                165                 170                 175     
Ala Ser Pro Arg Met Ser Met Cys Gly Glu Lys Arg Glu Gly Ser Gly
            180                 185                 190         
Ser Glu Trp Ala Ala Ser Glu Gly Cys Pro Ser Leu Gly Cys Pro Ser
        195                 200                 205             
Val Val Pro Ser Pro Cys Ser Ser Glu Lys Thr Phe Asp Phe Lys Gly
    210                 215                 220                 
Leu Arg Arg Met Ser Arg Thr Phe Ser Glu Cys Ser Tyr Pro Glu Thr
225                 230                 235                 240 
Glu Glu Glu Gly Glu Ala Leu Pro Val Arg Asp Ser Phe Tyr Arg Leu
                245                 250                 255     
Glu Lys Arg Leu Gly Arg Ser Glu Pro Ser Ala Phe Leu Arg Gly His
            260                 265                 270         
Gly Ser Arg Lys Glu Ser Ser Ala Val Leu Ser Arg Ile Gln Lys Ile
        275                 280                 285             
Glu Gln Val Leu Lys Glu Gln Pro Gly Arg Gly Leu Pro Gln Leu Pro
    290                 295                 300                 
Ser Ser Cys Tyr Ser Val Asp Arg Gly Lys Arg Lys Thr Gly Thr Leu
305                 310                 315                 320 
Gly Ser Leu Glu Glu Pro Ala Gly Gly Ala Ser Val Ser Ala Gly Ser
                325                 330                 335     
Arg Ala Val Gly Val Ala Gly Val Ala Gly Glu Ala Gly Pro Pro Pro
            340                 345                 350         
Glu Arg Glu Gly Ser Gly Ser Thr Lys Pro Gly Thr Pro Gly Asn Ser
        355                 360                 365             
Pro Ser Ser Gln Arg Leu Pro Ser Lys Ser Ser Leu Asp Pro Ala Val
    370                 375                 380                 
Asn Pro Val Pro Lys Pro Lys Arg Thr Phe Glu Tyr Glu Ala Glu Lys
385                 390                 395                 400 
Asn Pro Lys Ser Lys Pro Ser Asn Gly Leu Pro Pro Ser Pro Thr Pro
                405                 410                 415     
Ala Ala Pro Pro Pro Leu Pro Ser Thr Pro Ala Pro Pro Val Thr Arg
            420                 425                 430         
Arg Pro Lys Lys Asp Met Arg Gly His Arg Lys Ser Gln Ser Arg Lys
        435                 440                 445             
Ser Phe Glu Phe Glu Asp Ala Ser Ser Leu Gln Ser Leu Tyr Pro Ser
    450                 455                 460                 
Ser Pro Thr Glu Asn Gly Thr Glu Asn Gln Pro Lys Phe Gly Ser Lys
465                 470                 475                 480 
Ser Thr Leu Glu Glu Asn Ala Tyr Glu Asp Ile Val Gly Asp Leu Pro
                485                 490                 495     
Lys Glu Asn Pro Tyr Glu Asp Val Asp Leu Lys Ser Arg Arg Ala Gly
            500                 505                 510         
Arg Lys Ser Gln Gln Leu Ser Glu Asn Ser Leu Asp Ser Leu His Arg
        515                 520                 525             
Met Trp Ser Pro Gln Asp Arg Lys Tyr Asn Ser Pro Pro Thr Gln Leu
    530                 535                 540                 
Ser Leu Lys Pro Asn Ser Gln Ser Leu Arg Ser Gly Asn Trp Ser Glu
545                 550                 555                 560 
Arg Lys Ser His Arg Leu Pro Arg Leu Pro Lys Arg His Ser His Asp
                565                 570                 575     
Asp Met Leu Leu Leu Ala Gln Leu Ser Leu Pro Ser Ser Pro Ser Ser
            580                 585                 590         
Leu Asn Glu Asp Ser Leu Ser Thr Thr Ser Glu Leu Leu Ser Ser Arg
        595                 600                 605             
Arg Ala Arg Arg Ile Pro Lys Leu Val Gln Arg Ile Asn Ser Ile Tyr
    610                 615                 620                 
Asn Ala Lys Arg Gly Lys Lys Arg Leu Lys Lys Leu Ser Met Ser Ser
625                 630                 635                 640 
Ile Glu Thr Ala Ser Leu Arg Asp Glu Asn Ser Glu Ser Glu Ser Asp
                645                 650                 655     
Ser Asp Asp Arg Phe Lys Ala His Thr Gln Arg Leu Val His Ile Gln
            660                 665                 670         
Ser Met Leu Lys Arg Ala Pro Ser Tyr Arg Thr Leu Glu Leu Glu Leu
        675                 680                 685             
Leu Glu Trp Gln Glu Arg Glu Leu Phe Glu Tyr Phe Val Val Val Ser
    690                 695                 700                 
Leu Lys Lys Lys Pro Ser Arg Asn Thr Tyr Leu Pro Glu Val Ser Tyr
705                 710                 715                 720 
Gln Phe Pro Lys Leu Asp Arg Pro Thr Lys Gln Met Arg Glu Ala Glu
                725                 730                 735     
Glu Arg Leu Lys Ala Ile Pro Gln Phe Cys Phe Pro Asp Ala Lys Asp
            740                 745                 750         
Trp Leu Pro Val Ser Glu Tyr Ser Ser Glu Thr Phe Ser Phe Met Leu
        755                 760                 765             
Thr Gly Glu Asp Gly Ser Arg Arg Phe Gly Tyr Cys Arg Arg Leu Leu
    770                 775                 780                 
Pro Ser Gly Lys Gly Pro Arg Leu Pro Glu Val Tyr Cys Val Ile Ser
785                 790                 795                 800 
Arg Leu Gly Cys Phe Gly Leu Phe Ser Lys Val Leu Asp Glu Val Glu
                805                 810                 815     
Arg Arg Arg Gly Ile Ser Ala Ala Leu Val Tyr Pro Phe Met Arg Ser
            820                 825                 830         
Leu Met Glu Ser Pro Phe Pro Ala Pro Gly Lys Thr Ile Lys Val Lys
        835                 840                 845             
Thr Phe Leu Pro Gly Ala Gly Asn Glu Val Leu Glu Leu Arg Arg Pro
    850                 855                 860                 
Met Asp Ser Arg Leu Glu His Val Asp Phe Glu Cys Leu Phe Thr Cys
865                 870                 875                 880 
Leu Ser Val Arg Gln Leu Ile Arg Ile Phe Ala Ser Leu Leu Leu Glu
                885                 890                 895     
Arg Arg Val Ile Phe Val Ala Asp Lys Leu Ser Thr Leu Ser Ser Cys
            900                 905                 910         
Ser His Ala Val Val Ala Leu Leu Tyr Pro Phe Ser Trp Gln His Thr
        915                 920                 925             
Phe Ile Pro Val Leu Pro Ala Ser Met Ile Asp Ile Val Cys Cys Pro
    930                 935                 940                 
Thr Pro Phe Leu Val Gly Leu Leu Ser Ser Ser Leu Pro Lys Leu Lys
945                 950                 955                 960 
Glu Leu Pro Val Glu Glu Ala Leu Met Val Asn Leu Gly Ser Asp Arg
                965                 970                 975     
Phe Ile Arg Gln Met Asp Asp Glu Asp Thr Leu Leu Pro Arg Lys Leu
            980                 985                 990         
Gln Ala Ala Leu Glu Gln Ala Leu Glu Arg Lys Asn Glu Leu Ile Ser
        995                 1000                1005            
Gln Asp Ser Asp Ser Asp Ser Asp Asp Glu Cys Asn Thr Leu Asn Gly
    1010                1015                1020                
Leu Val Ser Glu Val Phe Ile Arg Phe Phe Val Glu Thr Val Gly His
1025                1030                1035                1040
Tyr Ser Leu Phe Leu Thr Gln Ser Glu Lys Gly Glu Arg Ala Phe Gln
                1045                1050                1055    
Arg Glu Ala Phe Arg Lys Ser Val Ala Ser Lys Ser Ile Arg Arg Phe
            1060                1065                1070        
Leu Glu Val Phe Met Glu Ser Gln Met Phe Ala Gly Phe Ile Gln Asp
        1075                1080                1085            
Arg Glu Leu Arg Lys Cys Arg Ala Lys Gly Leu Phe Glu Gln Arg Val
    1090                1095                1100                
Glu Gln Tyr Leu Glu Glu Leu Pro Asp Thr Glu Gln Ser Gly Met Asn
1105                1110                1115                1120
Lys Phe Leu Arg Gly Leu Gly Asn Lys Met Lys Phe Leu His Lys Lys
                1125                1130                1135    
Asn
    


<210> 2844
<211> 113
<212> PRT
<213> Homo sapiens

<400> 2844
Met Asp Lys Ile Leu Glu Ala Val Val Thr Ser Ser Tyr Pro Val Ser
 1               5                  10                  15      
Val Lys Gln Gly Leu Val Arg Arg Val Leu Glu Ala Ala Arg Gln Pro
            20                  25                  30          
Leu Glu Arg Glu Gln Cys Leu Ala Leu Leu Ala Leu Gly Ala Arg Leu
        35                  40                  45              
Tyr Val Gly Gly Ala Glu Glu Leu Pro Arg Arg Val Gly Cys Gln Leu
    50                  55                  60                  
Leu His Val Ala Gly Arg His His Pro Asp Val Phe Ala Glu Phe Phe
65                  70                  75                  80  
Ser Ala Arg Arg Val Leu Arg Leu Leu Gln Gly Gly Ala Gly Pro Pro
                85                  90                  95      
Gly Pro Arg Ala Leu Ala Cys Val Gln Leu Gly Leu Gln Leu Leu Pro
            100                 105                 110         
Glu
    


<210> 2845
<211> 241
<212> PRT
<213> Homo sapiens

<400> 2845
Met Ser Pro Leu Leu Gly Leu Arg Ser Glu Leu Gln Asp Thr Cys Thr
 1               5                  10                  15      
Ser Leu Gly Leu Met Leu Ser Val Val Leu Leu Met Gly Leu Ala Arg
            20                  25                  30          
Val Val Ala Arg Gln Gln Leu His Arg Pro Val Ala His Ala Phe Val
        35                  40                  45              
Leu Glu Phe Leu Ala Thr Phe Gln Leu Cys Cys Cys Thr His Glu Leu
    50                  55                  60                  
Gln Leu Leu Ser Glu Gln His Pro Ala His Pro Thr Trp Thr Leu Thr
65                  70                  75                  80  
Leu Val Tyr Phe Phe Ser Leu Val His Gly Leu Thr Leu Val Gly Thr
                85                  90                  95      
Ser Ser Asn Pro Cys Gly Val Met Met Gln Met Met Leu Gly Gly Met
            100                 105                 110         
Ser Pro Glu Thr Gly Ala Val Arg Leu Leu Ala Gln Leu Val Ser Ala
        115                 120                 125             
Leu Cys Ser Arg Tyr Cys Thr Ser Ala Leu Trp Ser Leu Gly Leu Thr
    130                 135                 140                 
Gln Tyr His Val Ser Glu Arg Ser Phe Ala Cys Lys Asn Pro Ile Arg
145                 150                 155                 160 
Val Asp Leu Leu Lys Ala Val Ile Thr Glu Ala Val Cys Ser Phe Leu
                165                 170                 175     
Phe His Ser Ala Leu Leu His Phe Gln Glu Val Arg Thr Lys Leu Arg
            180                 185                 190         
Ile His Leu Leu Ala Ala Leu Ile Thr Phe Leu Val Tyr Ala Gly Leu
        195                 200                 205             
Ser Phe Ser Pro Asn Thr Trp His Phe Gln Ser Leu Tyr Asp Met Arg
    210                 215                 220                 
Leu Tyr Ile Val Asp Asp Phe Asp Val Gln Leu Phe Pro Ser Met Ala
225                 230                 235                 240 
Ala
    


<210> 2846
<211> 148
<212> PRT
<213> Homo sapiens

<400> 2846
Met Ile Arg Val Ser Tyr Leu Gly Asp Asp Gly Ile Gln Arg Ala Asp
 1               5                  10                  15      
Ser Asp Thr Gly Glu Leu Gly Val Val Leu Pro Glu Ser Thr Glu Ser
            20                  25                  30          
Leu Lys Gly Asp Gly Gly Val Arg Ala Thr Ser Ser Ser Arg Ser Gly
        35                  40                  45              
Leu Ala Ala Ala Ala Ser Gly Pro Ala Ala Gly Leu Ser Arg Ala Ala
    50                  55                  60                  
Ser Pro Ala Ala Cys Ala Pro Ala Ala Gly Cys Ala Pro Pro Val Thr
65                  70                  75                  80  
Ser Met Ala Gly Arg Gly Trp Ile Ser Ala Lys Val Val Met Val Val
                85                  90                  95      
Gly Asn Trp Ile Ser Leu Gly Ile Arg Cys Pro Leu Ala Ser Gly Thr
            100                 105                 110         
Trp Gln Arg Arg Asn Gly Pro Val Tyr Leu Arg Asp Leu Ile Gly Arg
        115                 120                 125             
Met Val Ala Asn Tyr Thr Leu Ser Pro Ile Arg Arg Ile Arg Asn Arg
    130                 135                 140                 
Cys Phe Glu Ser
145             


<210> 2847
<211> 238
<212> PRT
<213> Homo sapiens

<400> 2847
Met Ala Lys Val Gly Ile Ala Arg Asn Ile Gln Phe Glu Tyr Met Lys
 1               5                  10                  15      
Gln Asp Ser Asn Asp Met Asp Lys Thr Glu Ala Gly Gly Asp Ala Asn
            20                  25                  30          
Leu Ile Asp Ile Tyr Pro Leu Ser Lys Gly Arg Ser Phe Trp Gln Ile
        35                  40                  45              
Cys Val Val Gly Asn Lys Ala Gln Trp Asn Ala His Val Val His Ser
    50                  55                  60                  
Leu Lys Thr Gln Lys Trp Lys Ser Cys Lys Val Lys Pro Gln Val Gln
65                  70                  75                  80  
Arg His Thr Ala Glu Ala Thr Gln Asp Thr Gly Leu Pro Pro Leu Glu
                85                  90                  95      
Ser Ala Ala Arg Leu Arg His Leu Glu Pro Gln Lys Asp Leu Glu Gly
            100                 105                 110         
Val Asp Ser Trp Glu Lys Ile Leu Leu Ser Ser Leu Ala Gly Thr Met
        115                 120                 125             
Asp Thr Phe Gln Ser Leu Asp Lys Ser Ala Ser Phe Ile Thr Ser Thr
    130                 135                 140                 
Asn Ala Gln Glu Phe Lys Gly Ile Leu Gln Ser Asp Trp Gly Arg Glu
145                 150                 155                 160 
Leu Gln Ser Ile Pro Ala Ala Trp Leu Asp Ser Gly Gly Ala Gln Asn
                165                 170                 175     
Leu Ile Gln Asn Leu Ser Arg Met Asp Gln Pro His Leu Gly Lys Trp
            180                 185                 190         
His Leu Leu Ser Gln Ile Met Ser Phe Ser Ala Ala Asp Thr Ala Gly
        195                 200                 205             
Ser Glu Ala Ala Glu Lys Met Leu His Thr Ser Val Val Thr Ser Ala
    210                 215                 220                 
Ala Val His Met Ala Ile Lys Glu Thr Gly Asn Asn Ala Pro
225                 230                 235             


<210> 2848
<211> 638
<212> PRT
<213> Homo sapiens

<400> 2848
Met Gly Lys Ile Glu Asn Asn Glu Arg Val Ile Leu Asn Val Gly Gly
 1               5                  10                  15      
Thr Arg His Glu Thr Tyr Arg Ser Thr Leu Lys Thr Leu Pro Gly Thr
            20                  25                  30          
Arg Leu Ala Leu Leu Ala Ser Ser Glu Pro Pro Gly Asp Cys Leu Thr
        35                  40                  45              
Thr Ala Gly Asp Lys Leu Gln Pro Ser Pro Pro Pro Leu Ser Pro Pro
    50                  55                  60                  
Pro Arg Ala Pro Pro Leu Ser Pro Gly Pro Gly Gly Cys Phe Glu Gly
65                  70                  75                  80  
Gly Ala Gly Asn Cys Ser Ser Arg Gly Gly Arg Ala Ser Asp His Pro
                85                  90                  95      
Gly Gly Gly Arg Glu Phe Phe Phe Asp Arg His Pro Gly Val Phe Ala
            100                 105                 110         
Tyr Val Leu Asn Tyr Tyr Arg Thr Gly Lys Leu His Cys Pro Ala Asp
        115                 120                 125             
Val Cys Gly Pro Leu Phe Glu Glu Glu Leu Ala Phe Trp Gly Ile Asp
    130                 135                 140                 
Glu Thr Asp Val Glu Pro Cys Cys Trp Met Thr Tyr Arg Gln His Arg
145                 150                 155                 160 
Asp Ala Glu Glu Ala Leu Asp Ile Phe Glu Thr Pro Asp Leu Ile Gly
                165                 170                 175     
Gly Asp Pro Gly Asp Asp Glu Asp Leu Ala Ala Lys Arg Leu Gly Ile
            180                 185                 190         
Glu Asp Ala Ala Gly Leu Gly Gly Pro Asp Gly Lys Ser Gly Arg Trp
        195                 200                 205             
Arg Arg Leu Gln Pro Arg Met Trp Ala Leu Phe Glu Asp Pro Tyr Ser
    210                 215                 220                 
Ser Arg Ala Ala Arg Phe Ile Ala Phe Ala Ser Leu Phe Phe Ile Leu
225                 230                 235                 240 
Val Ser Ile Thr Thr Phe Cys Leu Glu Thr His Glu Ala Phe Asn Ile
                245                 250                 255     
Val Lys Asn Lys Thr Glu Pro Val Ile Asn Gly Thr Ser Val Val Leu
            260                 265                 270         
Gln Tyr Glu Ile Glu Thr Asp Pro Ala Leu Thr Tyr Val Glu Gly Val
        275                 280                 285             
Cys Val Val Trp Phe Thr Phe Glu Phe Leu Val Arg Ile Val Phe Ser
    290                 295                 300                 
Pro Asn Lys Leu Glu Phe Ile Lys Asn Leu Leu Asn Ile Ile Asp Phe
305                 310                 315                 320 
Val Ala Ile Leu Pro Phe Tyr Leu Glu Val Gly Leu Ser Gly Leu Ser
                325                 330                 335     
Ser Lys Ala Ala Lys Asp Val Leu Gly Phe Leu Arg Val Val Arg Phe
            340                 345                 350         
Val Arg Ile Leu Arg Ile Phe Lys Leu Thr Arg His Phe Val Gly Leu
        355                 360                 365             
Arg Val Leu Gly His Thr Leu Arg Ala Ser Thr Asn Glu Phe Leu Leu
    370                 375                 380                 
Leu Ile Ile Phe Leu Ala Leu Gly Val Leu Ile Phe Ala Thr Met Ile
385                 390                 395                 400 
Tyr Tyr Ala Glu Arg Val Gly Ala Gln Pro Asn Asp Pro Ser Ala Ser
                405                 410                 415     
Glu His Thr Gln Phe Lys Asn Ile Pro Ile Gly Phe Trp Trp Ala Val
            420                 425                 430         
Val Thr Met Thr Thr Leu Gly Tyr Gly Asp Met Tyr Pro Gln Thr Trp
        435                 440                 445             
Ser Gly Met Leu Val Gly Ala Leu Cys Ala Leu Ala Gly Val Leu Thr
    450                 455                 460                 
Ile Ala Met Pro Val Pro Val Ile Val Asn Asn Phe Gly Met Tyr Tyr
465                 470                 475                 480 
Ser Leu Ala Met Ala Lys Gln Lys Leu Pro Arg Lys Arg Lys Lys His
                485                 490                 495     
Ile Pro Pro Ala Pro Gln Ala Ser Ser Pro Thr Phe Cys Lys Thr Glu
            500                 505                 510         
Leu Asn Met Ala Cys Asn Ser Thr Gln Ser Asp Thr Cys Leu Gly Lys
        515                 520                 525             
Asp Asn Arg Leu Leu Glu His Asn Arg Ser Val Leu Ser Gly Asp Asp
    530                 535                 540                 
Ser Thr Gly Ser Glu Pro Pro Leu Ser Pro Pro Glu Arg Leu Pro Ile
545                 550                 555                 560 
Arg Arg Ser Ser Thr Arg Asp Lys Asn Arg Arg Gly Glu Thr Cys Phe
                565                 570                 575     
Leu Leu Thr Thr Gly Asp Tyr Thr Cys Ala Ser Asp Gly Gly Ile Arg
            580                 585                 590         
Lys Gly Tyr Glu Lys Ser Arg Ser Leu Asn Asn Ile Ala Gly Leu Ala
        595                 600                 605             
Gly Asn Ala Leu Arg Leu Ser Pro Val Thr Ser Pro Tyr Asn Ser Pro
    610                 615                 620                 
Cys Pro Leu Arg Arg Ser Arg Ser Pro Ile Pro Ser Ile Leu
625                 630                 635             


<210> 2849
<211> 252
<212> PRT
<213> Homo sapiens

<400> 2849
Met Glu Ser Asn Gly Ile Phe Thr Thr Leu Ala Lys Ala Gly Ala His
 1               5                  10                  15      
Leu Glu Arg Gly Thr Lys Arg Phe Ile Ile Ser Ile Pro Ser Ala Asp
            20                  25                  30          
Val Pro Met Phe Val Met Gly Met Asn His Lys His Glu Asn Lys Leu
        35                  40                  45              
Thr Val Ile Ser Asn Ala Ser Cys Thr Thr Asn Cys Leu Asp Pro Leu
    50                  55                  60                  
Ala Lys Val Ile His Asp Asn Phe Gly Ile Arg Glu Gly Leu Met Thr
65                  70                  75                  80  
Thr Val His Ser Ile Ile Ala Thr Gln Lys Thr Val Asp Gly Pro Ser
                85                  90                  95      
Arg Lys Leu Trp His Asp Ser His Gly Ala Phe Gln Asn Thr Ile Pro
            100                 105                 110         
Ala Ser Thr Gly Ala Ala Lys His Gln Lys Gly Gly Glu Ala Gly Thr
        115                 120                 125             
Gln Gly Pro Leu Lys Gly Ile Leu Gly Tyr Thr Glu His Gln Val Val
    130                 135                 140                 
Pro Leu Glu Phe Lys Ser Asn Thr Arg Pro Ser Thr Phe Glu Ala Gly
145                 150                 155                 160 
Ala Gly Ile Ala Val Asn Asp His Phe Val Lys Leu Ile Ser Trp Tyr
                165                 170                 175     
Gly Asn Glu Phe Ala Tyr Ser Asn Lys Asp Glu Gln Leu Gln Lys Thr
            180                 185                 190         
Lys Ala Asn Arg Ala Ala Glu Glu Ala Phe Val Asn Asp Ile Asp Gln
        195                 200                 205             
Phe Phe Pro Gly Thr Glu Trp Glu Ser Val Ala Trp Leu Cys Asn Phe
    210                 215                 220                 
Asn Pro Lys Ser Arg Arg Gln Ala Lys Asp Ile Ser Gln Arg Cys Ser
225                 230                 235                 240 
Val Leu Ile Ser Leu Lys Gln Ala Pro Leu Val His
                245                 250         


<210> 2850
<211> 1204
<212> PRT
<213> Homo sapiens

<400> 2850
Met Gly Leu Met Glu Tyr Lys Thr Gly Lys Arg Ile Ile Asp Glu Glu
 1               5                  10                  15      
Gly Val Glu Ser Ile Asn Asp Met Phe His Glu Asn Ala Met Leu Gln
            20                  25                  30          
Thr Glu Asn Asn Asn Leu Arg Val Arg Ile Lys Ala Met Gln Glu Thr
        35                  40                  45              
Val Asp Ala Leu Arg Ser Arg Ile Thr Gln Leu Val Ser Asp Gln Ala
    50                  55                  60                  
Asn His Val Leu Ala Arg Ala Gly Glu Gly Asn Glu Glu Ile Ser Asn
65                  70                  75                  80  
Met Ile His Ser Tyr Ile Lys Glu Ile Glu Asp Leu Arg Ala Lys Leu
                85                  90                  95      
Leu Glu Ser Glu Ala Val Asn Glu Asn Leu Arg Lys Asn Leu Thr Arg
            100                 105                 110         
Ala Thr Ala Arg Ala Pro Tyr Phe Ser Gly Ser Ser Thr Phe Ser Pro
        115                 120                 125             
Thr Ile Leu Ser Ser Asp Lys Glu Thr Ile Glu Ile Ile Asp Leu Ala
    130                 135                 140                 
Lys Lys Asp Leu Glu Lys Leu Lys Arg Lys Glu Lys Arg Lys Lys Lys
145                 150                 155                 160 
Ser Val Ala Gly Lys Glu Asp Asn Thr Asp Thr Asp Gln Glu Lys Lys
                165                 170                 175     
Glu Glu Lys Gly Val Ser Glu Arg Glu Asn Asn Glu Leu Glu Val Glu
            180                 185                 190         
Glu Ser Gln Glu Val Ser Asp His Glu Asp Glu Glu Glu Glu Glu Glu
        195                 200                 205             
Glu Glu Glu Asp Asp Ile Asp Gly Gly Glu Ser Ser Asp Glu Ser Asp
    210                 215                 220                 
Ser Glu Ser Asp Glu Lys Ala Asn Tyr Gln Ala Asp Leu Ala Asn Ile
225                 230                 235                 240 
Thr Cys Glu Ile Ala Ile Lys Gln Lys Leu Ile Asp Glu Leu Glu Asn
                245                 250                 255     
Ser Gln Lys Arg Leu Gln Thr Leu Lys Lys Gln Tyr Glu Glu Lys Leu
            260                 265                 270         
Met Met Leu Gln His Lys Ile Arg Asp Thr Gln Leu Glu Arg Asp Gln
        275                 280                 285             
Val Leu Gln Asn Leu Gly Ser Val Glu Ser Tyr Ser Glu Glu Lys Ala
    290                 295                 300                 
Lys Lys Val Arg Ser Glu Tyr Glu Lys Lys Leu Gln Ala Met Asn Lys
305                 310                 315                 320 
Glu Leu Gln Arg Leu Gln Ala Ala Gln Lys Glu His Ala Arg Leu Leu
                325                 330                 335     
Lys Asn Gln Ser Gln Tyr Glu Lys Gln Leu Lys Lys Leu Gln Gln Asp
            340                 345                 350         
Val Met Glu Met Lys Lys Thr Lys Val Arg Leu Met Lys Gln Met Lys
        355                 360                 365             
Glu Glu Gln Glu Lys Ala Arg Leu Thr Glu Ser Arg Arg Asn Arg Glu
    370                 375                 380                 
Ile Ala Gln Leu Lys Lys Asp Gln Arg Lys Arg Asp His Gln Leu Arg
385                 390                 395                 400 
Leu Leu Glu Ala Gln Lys Arg Asn Gln Glu Val Val Leu Arg Arg Lys
                405                 410                 415     
Thr Glu Glu Val Thr Ala Leu Arg Arg Gln Val Arg Pro Met Ser Asp
            420                 425                 430         
Lys Val Ala Gly Lys Val Thr Arg Lys Leu Ser Ser Ser Asp Ala Pro
        435                 440                 445             
Ala Gln Asp Thr Gly Ser Ser Ala Ala Ala Val Glu Thr Asp Ala Ser
    450                 455                 460                 
Arg Thr Gly Ala Gln Gln Lys Met Arg Ile Pro Val Ala Arg Val Gln
465                 470                 475                 480 
Ala Leu Pro Thr Pro Ala Thr Asn Gly Asn Arg Lys Lys Tyr Gln Arg
                485                 490                 495     
Lys Gly Leu Thr Gly Arg Val Phe Ile Ser Lys Thr Ala Arg Met Lys
            500                 505                 510         
Trp Gln Leu Leu Glu Arg Arg Val Thr Asp Ile Ile Met Gln Lys Met
        515                 520                 525             
Thr Ile Ser Asn Met Glu Ala Asp Met Asn Arg Leu Leu Lys Gln Arg
    530                 535                 540                 
Glu Glu Leu Thr Lys Arg Arg Glu Lys Leu Ser Lys Arg Arg Glu Lys
545                 550                 555                 560 
Ile Val Lys Glu Asn Gly Glu Gly Asp Lys Asn Val Ala Asn Ile Asn
                565                 570                 575     
Glu Glu Met Glu Ser Leu Thr Ala Asn Ile Asp Tyr Ile Asn Asp Ser
            580                 585                 590         
Ile Ser Asp Cys Gln Ala Asn Ile Met Gln Met Glu Glu Ala Lys Glu
        595                 600                 605             
Glu Gly Glu Thr Leu Asp Val Thr Ala Val Ile Asn Ala Cys Thr Leu
    610                 615                 620                 
Thr Glu Ala Arg Tyr Leu Leu Asp His Phe Leu Ser Met Gly Ile Asn
625                 630                 635                 640 
Lys Gly Leu Gln Ala Ala Gln Lys Glu Ala Gln Ile Lys Val Leu Glu
                645                 650                 655     
Gly Arg Leu Lys Gln Thr Glu Ile Thr Ser Ala Thr Gln Asn Gln Leu
            660                 665                 670         
Leu Phe His Met Leu Lys Glu Lys Ala Glu Leu Asn Pro Glu Leu Asp
        675                 680                 685             
Ala Leu Leu Gly His Ala Leu Gln Asp Leu Asp Ser Val Pro Leu Glu
    690                 695                 700                 
Asn Val Glu Asp Ser Thr Asp Glu Asp Ala Pro Leu Asn Ser Pro Gly
705                 710                 715                 720 
Ser Glu Gly Ser Thr Leu Ser Ser Asp Leu Met Lys Leu Cys Gly Glu
                725                 730                 735     
Val Lys Pro Lys Asn Lys Ala Arg Arg Arg Thr Thr Thr Gln Met Glu
            740                 745                 750         
Leu Leu Tyr Ala Asp Ser Ser Glu Leu Ala Ser Asp Thr Ser Thr Gly
        755                 760                 765             
Asp Ala Ser Leu Pro Gly Pro Leu Thr Pro Val Ala Glu Gly Gln Glu
    770                 775                 780                 
Ile Gly Met Asn Thr Glu Thr Ser Gly Thr Ser Ala Arg Glu Lys Glu
785                 790                 795                 800 
Leu Ser Pro Pro Pro Gly Leu Pro Ser Lys Ile Gly Ser Ile Ser Arg
                805                 810                 815     
Gln Ser Ser Leu Ser Glu Lys Lys Ile Pro Glu Pro Ser Pro Val Thr
            820                 825                 830         
Arg Arg Lys Ala Tyr Glu Lys Ala Glu Lys Ser Lys Ala Lys Glu Gln
        835                 840                 845             
Lys Gln Gly Ile Ile Asn Pro Phe Pro Ala Ser Lys Gly Ile Arg Ala
    850                 855                 860                 
Phe Pro Leu Gln Cys Ile His Ile Ala Glu Gly His Thr Lys Ala Val
865                 870                 875                 880 
Leu Cys Val Asp Ser Thr Asp Asp Leu Leu Phe Thr Gly Ser Lys Asp
                885                 890                 895     
Arg Thr Cys Lys Val Trp Asn Leu Val Thr Gly Gln Glu Ile Met Ser
            900                 905                 910         
Leu Gly Gly His Pro Asn Asn Val Val Ser Val Lys Tyr Cys Asn Tyr
        915                 920                 925             
Thr Ser Leu Val Phe Thr Val Ser Thr Ser Tyr Ile Lys Val Trp Asp
    930                 935                 940                 
Ile Arg Asp Ser Ala Lys Cys Ile Arg Thr Leu Thr Ser Ser Gly Gln
945                 950                 955                 960 
Val Thr Leu Gly Asp Ala Cys Ser Ala Ser Thr Ser Arg Thr Val Ala
                965                 970                 975     
Ile Pro Ser Gly Glu Asn Gln Ile Asn Gln Ile Ala Leu Asn Pro Thr
            980                 985                 990         
Gly Thr Phe Leu Tyr Ala Ala Ser Gly Asn Ala Val Arg Met Trp Asp
        995                 1000                1005            
Leu Lys Arg Phe Gln Ser Thr Gly Lys Leu Thr Gly His Leu Gly Pro
    1010                1015                1020                
Val Met Cys Leu Thr Val Asp Gln Ile Ser Ser Gly Gln Asp Leu Ile
1025                1030                1035                1040
Ile Thr Gly Ser Lys Asp His Tyr Ile Lys Met Phe Asp Val Thr Glu
                1045                1050                1055    
Gly Ala Leu Gly Thr Val Ser Pro Thr His Asn Phe Glu Pro Pro His
            1060                1065                1070        
Tyr Asp Gly Ile Glu Ala Leu Thr Ile Gln Gly Asp Asn Leu Phe Ser
        1075                1080                1085            
Gly Ser Arg Asp Asn Gly Ile Lys Lys Trp Asp Leu Thr Gln Lys Asp
    1090                1095                1100                
Leu Leu Gln Gln Val Pro Asn Ala His Lys Asp Trp Val Cys Ala Leu
1105                1110                1115                1120
Gly Val Val Pro Asp His Pro Val Leu Leu Ser Gly Cys Arg Gly Gly
                1125                1130                1135    
Ile Leu Lys Val Trp Asn Met Asp Thr Phe Met Pro Val Gly Glu Met
            1140                1145                1150        
Lys Gly His Asp Ser Pro Ile Asn Ala Ile Cys Val Asn Ser Thr His
        1155                1160                1165            
Ile Phe Thr Ala Ala Asp Asp Arg Thr Val Arg Ile Trp Lys Ala Arg
    1170                1175                1180                
Asn Leu Gln Asp Gly Gln Ile Ser Asp Thr Gly Asp Leu Gly Glu Asp
1185                1190                1195                1200
Ile Ala Ser Asn
                


<210> 2851
<211> 243
<212> PRT
<213> Homo sapiens

<400> 2851
Met Ser Asn Gly Gln Thr Glu Glu Asn Thr Glu Leu Arg Ser Gln His
 1               5                  10                  15      
Trp Ala Thr Ala Val Arg Val Leu Leu Val Gly Thr Lys Gln Val Val
            20                  25                  30          
Leu Gly Ala Asp Asp Lys Leu Ser Lys Glu Val Ser Phe Ile Leu Asn
        35                  40                  45              
Val Glu Arg Gly Phe Val Ser Ile Thr Met Phe Pro Arg Gly Glu Gly
    50                  55                  60                  
Glu Lys Ala Ser Val Ser Gln Cys Pro Gln Phe Gly Arg Ala Asn Cys
65                  70                  75                  80  
Ser Ser Phe Arg Gly Gln Asn Lys Leu Gln Asp Thr Glu Ser Phe Ile
                85                  90                  95      
Ala Val Gln Trp Leu Gly Pro Asn Asn His Lys Pro Val Val Thr Ala
            100                 105                 110         
Ser Gly Ala Leu Asn Ser Ser Val His Ile Arg Tyr Ser Gly Gly Thr
        115                 120                 125             
Asp Ser Pro Gly Ala Ala Ala Leu Glu Asp Glu Arg Gly Gly Ala Glu
    130                 135                 140                 
Ser Pro Gly Glu Arg Glu Pro Ala Arg Lys Ser Glu Pro Asp Ser Glu
145                 150                 155                 160 
Arg Arg Glu Arg His His Ala Arg Leu Glu Glu Glu Tyr Pro Tyr Leu
                165                 170                 175     
Leu Ala Gly Arg Gly Ala Gly Glu Arg Lys Val Leu Trp Asn Arg Ile
            180                 185                 190         
Gly Phe Arg Met Gln Gly Leu His Gly Leu Trp Glu Thr Ala Gly Ala
        195                 200                 205             
Glu Val Lys Arg Arg Ser Val Gly Ser Val Tyr Gly Cys Arg Ser Val
    210                 215                 220                 
Leu Pro Pro Gln Ile Leu Ala Cys Val Leu Pro Asn Val Asp Pro Ala
225                 230                 235                 240 
Arg Thr Pro
            


<210> 2852
<211> 193
<212> PRT
<213> Homo sapiens

<400> 2852
Met Ser Thr Val Asp Gln Trp Thr Gly Gly Lys Gly Thr Gly Leu Leu
 1               5                  10                  15      
Thr Gly Gln Gln Val Leu Pro Glu Gly Pro Arg Lys Leu His Arg His
            20                  25                  30          
Pro Thr Leu Gln Ser Leu Leu Ala Glu Asn His Gly Gln Ala Ser Thr
        35                  40                  45              
Pro Ser Glu Lys Pro Ser Glu Thr Ser Ile Ala Val Thr Phe Leu Lys
    50                  55                  60                  
Val Leu Gly Arg Ala Lys Glu Met Glu Met Ile Gln Gln Leu Glu Pro
65                  70                  75                  80  
Ser Thr Phe Gly Pro Ala Gly Cys Ala Ser Asp Cys Gly Ala Arg Met
                85                  90                  95      
Leu Leu Phe His Phe Gly Leu Leu Gln Leu Leu Asp Ser Leu Tyr Ala
            100                 105                 110         
Val Thr Cys Val Leu Trp Pro Cys Ser Asn Arg Ile Ala Ile Asp Ala
        115                 120                 125             
Leu Met Leu Ser Val Ala Ser His Val Ile Met Leu Thr Val Leu Leu
    130                 135                 140                 
Glu Asp Asp Ala Ile Cys His Thr Leu Lys Ala Thr Val Trp Leu Trp
145                 150                 155                 160 
Asn Ser Gly Arg Val Lys Thr Arg His Gly Ala Ala Arg Ile Lys Arg
                165                 170                 175     
Leu Leu Ser Pro Ala Phe Leu Pro Trp Arg His Asp Thr Pro Ser Ala
            180                 185                 190         
Leu
    


<210> 2853
<211> 106
<212> PRT
<213> Homo sapiens

<400> 2853
Met Lys Lys Leu Trp Trp Ile Arg Val Gly Pro Val Gln Phe Ser Thr
 1               5                  10                  15      
Phe Thr Met Lys Lys Lys Ser Trp Lys Val Thr Glu Leu Cys Met Trp
            20                  25                  30          
Glu Phe Gly Cys Arg Leu Ala Gly Arg Ala Ile Gly Ile Thr Ala Leu
        35                  40                  45              
Met Ala Arg Ser Thr Gly Asp Glu Gly Gly Ala Lys Glu Pro Ala Arg
    50                  55                  60                  
Gly Arg Lys Ala Trp Lys Pro Trp Pro Thr Thr His His Leu Ser Val
65                  70                  75                  80  
Phe Ser Ser Phe Leu Ala Pro Arg Lys Met Lys Ser Met Cys Leu Met
                85                  90                  95      
Ser Cys Leu Gln Ser Trp Met Arg Ser Val
            100                 105     


<210> 2854
<211> 143
<212> PRT
<213> Homo sapiens

<400> 2854
Met Asp Trp Ala Asn Val Pro Pro Leu Leu Glu Ser Gly Asp Leu Gly
 1               5                  10                  15      
Gly Lys Gly Arg Thr Gly Trp Leu Glu Glu Pro Pro Pro Cys Lys Gly
            20                  25                  30          
Pro Gly Gly Arg Leu Arg Arg Arg Gln Ala Gln Ser Ser Asn Met His
        35                  40                  45              
Leu Pro Gln Leu Gln Gly Arg Ser Gly Ala Cys Gln Phe Thr Pro Pro
    50                  55                  60                  
His Asp Leu Met Ala Val Cys Ala Arg His Trp Leu Arg Glu Gln His
65                  70                  75                  80  
Leu Thr Glu Lys Ile Leu Gly Trp Ala Thr Gly Gln Asn Trp Ala Lys
                85                  90                  95      
Thr Leu Glu Arg Gly Thr Trp Leu Lys Ala Thr Pro His Phe His Val
            100                 105                 110         
Ile Phe Gln Trp His Gln Leu Ser Trp Thr Asp Val Leu Thr Glu Leu
        115                 120                 125             
His Met Pro Gln Ser Ser Leu Val Ala Arg Val Ser Ser Val His
    130                 135                 140             


<210> 2855
<211> 427
<212> PRT
<213> Homo sapiens

<400> 2855
Met Thr Leu Arg Arg Leu Arg Lys Leu Gln Gln Lys Glu Glu Ala Ala
 1               5                  10                  15      
Ala Thr Pro Asp Pro Ala Ala Arg Thr Pro Asp Ser Glu Val Ala Pro
            20                  25                  30          
Ala Ala Pro Val Pro Thr Pro Gly Pro Pro Ala Ala Ala Ala Thr Pro
        35                  40                  45              
Gly Pro Pro Ala Asp Glu Leu Tyr Ala Ala Leu Glu Asp Tyr His Pro
    50                  55                  60                  
Ala Glu Leu Tyr Arg Ala Leu Ala Val Ser Gly Gly Thr Leu Pro Arg
65                  70                  75                  80  
Arg Lys Glu Pro Leu Ala Arg Gly Thr Glu Thr Ala Pro Gly Lys Leu
                85                  90                  95      
Lys Val Arg Glu Pro Pro Val Gly Glu Ala Gly Arg Trp Leu Arg Arg
            100                 105                 110         
Val Arg Ser His Ser Glu Glu Val Arg Gly Glu Pro Leu Thr Pro Asp
        115                 120                 125             
Ser Thr Pro Phe Arg Gly Asp Ser Pro Ile Pro Gly Leu Gly Ala Cys
    130                 135                 140                 
Arg Leu Ala Pro Arg Leu Thr Phe Gly Gly Gly Leu Ala Lys Ala Gln
145                 150                 155                 160 
Asn Arg Lys Ala Leu Gly Cys Ala Gly Ser Lys Glu Lys Gly Cys Ser
                165                 170                 175     
Gly Thr Gly Pro Pro Pro Arg Thr Lys Lys Leu Gly Arg Gly Ser Gly
            180                 185                 190         
Phe Arg Trp Lys Asn Leu Ser Gln Ser Pro Glu Gln Gln Arg Lys Val
        195                 200                 205             
Leu Thr Leu Glu Lys Glu Asp Asn Gln Thr Phe Gly Phe Glu Ile Gln
    210                 215                 220                 
Thr Tyr Gly Leu His His Arg Glu Glu Gln Arg Val Glu Met Val Thr
225                 230                 235                 240 
Phe Val Cys Arg Val His Glu Ser Ser Pro Ala Gln Leu Ala Gly Leu
                245                 250                 255     
Thr Pro Gly Asp Thr Ile Ala Ser Val Asn Gly Leu Asn Val Glu Gly
            260                 265                 270         
Ile Arg His Arg Glu Ile Val Asp Ile Ile Lys Ala Ser Gly Asn Val
        275                 280                 285             
Leu Arg Leu Glu Thr Leu Tyr Gly Thr Ser Ile Arg Lys Ala Glu Leu
    290                 295                 300                 
Glu Ala Arg Leu Gln Tyr Leu Lys Gln Thr Leu Tyr Glu Lys Trp Gly
305                 310                 315                 320 
Glu Tyr Arg Ser Leu Met Val Gln Glu Gln Arg Leu Val His Gly Leu
                325                 330                 335     
Val Val Lys Asp Pro Ser Ile Tyr Asp Thr Leu Glu Ser Val Arg Ser
            340                 345                 350         
Cys Leu Tyr Gly Ala Gly Leu Leu Pro Gly Ser Leu Pro Phe Gly Pro
        355                 360                 365             
Leu Leu Ala Val Pro Gly Arg Pro Arg Gly Gly Ala Arg Arg Ala Arg
    370                 375                 380                 
Gly Asp Ala Asp Asp Ala Ala Leu Cys Gly Pro Gly Leu Arg Lys Thr
385                 390                 395                 400 
Lys Tyr Arg Ser Phe Arg Arg Arg Leu Leu Lys Phe Ile Pro Gly Leu
                405                 410                 415     
Asn Arg Ser Leu Glu Glu Glu Glu Ser Gln Leu
            420                 425         


<210> 2856
<211> 476
<212> PRT
<213> Homo sapiens

<400> 2856
Met Lys Ile Leu Leu Val Pro Lys Glu Leu Cys Ala Phe Gly Glu Glu
 1               5                  10                  15      
Pro Ile Ser Met Arg Phe Ser Thr Asp Tyr Gly Phe Pro Arg Gln Leu
            20                  25                  30          
Lys Arg His Ser Gln Gly Leu Lys Glu Leu Met Gly Gln Pro Trp Arg
        35                  40                  45              
Arg Leu Lys Tyr Lys His Asn Val Phe Ala Leu Cys His Phe Gly Gly
    50                  55                  60                  
Ile His Phe Lys Ala Gly Thr Ser Asp Val Leu Arg Asn Lys Gly Leu
65                  70                  75                  80  
Leu Val Leu Leu Ser Ser Gly Ser Val Gly Lys Arg Lys Lys His Ile
                85                  90                  95      
Leu Lys Ala Trp Arg Arg Lys Val Ile Pro Gln Ile Lys Pro Lys Pro
            100                 105                 110         
Arg Ala Ala Leu Leu Lys Glu Ile Ala Ala Gln Asp Val Glu Lys Glu
        115                 120                 125             
Lys Glu Thr His Ser Tyr Leu Ser Lys Glu Glu Ile Lys Glu Lys Val
    130                 135                 140                 
His Lys Tyr Asn Leu Ala Val Thr Asp Lys Leu Lys Met Thr Leu Ala
145                 150                 155                 160 
Ser Thr Ala Leu Cys His Thr Glu Ala Cys Arg Glu Ser Ala Tyr Arg
                165                 170                 175     
Arg Glu Lys Pro Gln Gly Leu Gly Ile Gly Lys Arg Ala Asp Ser Gly
            180                 185                 190         
Ala Arg Asn Ser Asn Gly Ile Tyr Thr Gly Phe Ile Lys Val Gln Met
        195                 200                 205             
Glu Leu Cys Lys Pro Pro Gln Thr Ser Pro Asn Ser Gly Lys Leu Ser
    210                 215                 220                 
Pro Ser Ser Asn Gly Cys Met Asn Thr Leu His Ile Ser Ser Thr Asn
225                 230                 235                 240 
Thr Val Gly Glu Val Ile Glu Ala Leu Leu Lys Lys Phe Leu Val Thr
                245                 250                 255     
Glu Ser Pro Ala Lys Phe Ala Leu Tyr Lys Arg Cys His Arg Glu Asp
            260                 265                 270         
Gln Val Tyr Ala Cys Lys Leu Ser Asp Arg Glu His Pro Leu Tyr Leu
        275                 280                 285             
Arg Leu Val Ala Gly Pro Arg Thr Asp Thr Leu Ser Phe Val Leu Arg
    290                 295                 300                 
Glu His Glu Ile Gly Glu Trp Glu Ala Phe Ser Leu Pro Glu Leu Gln
305                 310                 315                 320 
Asn Phe Leu Arg Ile Leu Asp Lys Glu Glu Asp Glu Gln Leu Gln Asn
                325                 330                 335     
Leu Lys Arg Arg Tyr Thr Ala Tyr Arg Gln Lys Leu Glu Glu Ala Leu
            340                 345                 350         
Gln Glu Ser Ile His Val Asn Arg Lys Ala Gln Glu Ser Arg Asn Ser
        355                 360                 365             
Glu Glu Phe Ile Val Lys Asp Phe Val Arg Gly Leu Thr Glu Lys Ala
    370                 375                 380                 
Lys Cys Lys Phe Gly Arg Arg His Val Arg Trp Trp Arg Val Leu Arg
385                 390                 395                 400 
Ala Met Glu Gly Asp Leu Ala Phe Gln Leu Gly Val Val Glu Lys Gly
                405                 410                 415     
Val Val Ala Cys Lys Arg Val Lys Ser Ile Gln Cys Gly Gly Val Lys
            420                 425                 430         
Pro Ile Leu Gly Ser Leu Gly Phe Leu Val Gly Arg Ile Trp Glu Gln
        435                 440                 445             
Ser Gln Arg Gln Glu Leu Asn Gln Lys Glu Gly Pro Met Asn Ser Ala
    450                 455                 460                 
Ala Asp Gln Ser Glu Asn Gln Ala Gly Val Ala Tyr
465                 470                 475     


<210> 2857
<211> 207
<212> PRT
<213> Homo sapiens

<400> 2857
Met Ser Val Met Asp Gly Ser Gly Asn Asn Ser Asp Asp His Arg Arg
 1               5                  10                  15      
Lys Tyr Leu Asn Ile Pro Ser Ile Cys Arg Val Leu Ser Ser Ser Gly
            20                  25                  30          
Lys His Lys Lys Ile Ser Gly Arg Asn Lys Tyr Thr Lys Glu Ser Glu
        35                  40                  45              
Gln Arg Ala Glu Arg Glu Asn Ile Ala Phe Leu Val Lys Tyr Gly Asn
    50                  55                  60                  
Ser Trp His Gln Ser Ala Lys Leu Asn Ile Asn Ser Leu Phe Cys Ala
65                  70                  75                  80  
Ile Phe Lys Ser Leu Val Asp Gly Val Trp Asp Val Arg Val Glu Gln
                85                  90                  95      
Met Glu Glu Asn Gly Pro Gln Asp Lys Asn Leu Gln Val Leu Ser Asp
            100                 105                 110         
Gly Glu Gly Gly Pro Leu Phe Asp Lys Pro Leu Leu Val Phe Pro Arg
        115                 120                 125             
Ile Cys Lys Glu Tyr Met Asn Ile Asn Ser Ser Val Ser Leu Ser Phe
    130                 135                 140                 
Gly Glu Gly Ile Arg Leu Ala Gly Ile Asp Cys Asp Asn Arg Glu Lys
145                 150                 155                 160 
Lys Gln Trp Tyr Ser Ala Pro Gly Lys Val Gly Met Thr Pro His Pro
                165                 170                 175     
Arg Gln Val Phe Cys Gly His Cys Lys Met Gln Lys Arg Thr Ser Ile
            180                 185                 190         
Leu Leu Lys Leu His Met Lys Asn Glu Val Lys Glu Asp Arg Glu
        195                 200                 205         


<210> 2858
<211> 458
<212> PRT
<213> Homo sapiens

<400> 2858
Met Gly Gln Arg Gly Arg Ala Pro Leu Thr Glu Pro His Phe Ala Cys
 1               5                  10                  15      
Ser Asp Pro Leu Ser Ala Ser Leu Tyr Ser Ala Pro Thr Leu Thr Ala
            20                  25                  30          
Arg Glu Gly Asp Ala Gly Arg Trp Thr Arg Ile Cys Pro His Leu Ser
        35                  40                  45              
Pro Ser Pro Gly Asp Pro Ser Thr Val Pro Asp Pro Arg Glu Arg Gly
    50                  55                  60                  
Arg Glu Thr Cys Ala His Gly Gly Phe Arg Asp Arg Gly Pro Ala Val
65                  70                  75                  80  
Ala Ala Pro Val Pro Ser Ala Gly Arg Arg Pro Glu Ala Arg Leu Ala
                85                  90                  95      
Pro Thr Cys Ser Pro Ala Ser Arg Trp Arg Gln His Leu Ala Met Leu
            100                 105                 110         
Leu Gln Leu Leu Arg Ala Gly Ala Ser Leu Ile Ala Leu Ala Ser Leu
        115                 120                 125             
Pro Arg Cys Gln Ser Ala Val Thr Ile Gln Gly His Arg Glu Pro Lys
    130                 135                 140                 
Ser Gly Ala Cys Gln Ser Asn Gln Lys Ile Cys Leu Leu Arg Lys Ser
145                 150                 155                 160 
Gln Ser Pro Ala Ala Leu Gly Ser Ala Arg Gly Arg Leu Leu Ser Ser
                165                 170                 175     
Pro Asp Ala Arg Gly Ala Leu Ser Ser Leu Asp Cys Lys Asn Gln Gly
            180                 185                 190         
Gly Leu Ala Ala Ile Thr Ala Leu Ile Pro Ser Leu Ile Cys Leu Leu
        195                 200                 205             
Leu Arg Pro Thr Lys Asp Phe Ser Ser Arg Leu Thr Ser Ser Leu Pro
    210                 215                 220                 
Leu Thr His Thr His Thr His Thr Ser Ser Val Pro Ser Leu Pro Pro
225                 230                 235                 240 
Ser Leu Leu Phe Ser Gly Glu Arg Gln Leu Asp Arg Met Ile His Leu
                245                 250                 255     
Gln Glu Ser Ser Leu Gly His Ala Leu Leu Glu Phe Pro Gly Ser Arg
            260                 265                 270         
Arg Tyr Arg Val Ser Asn Val Ala Glu Leu Leu Gly Ser Ser Gly Gln
        275                 280                 285             
Glu Gly Gly Glu Ala Leu Ser Ser Ala Asp Val Pro Pro Pro Asp Ala
    290                 295                 300                 
Arg Val Pro Pro Ser Arg Cys Pro Cys Ser His Cys Ser Gln Ile Gly
305                 310                 315                 320 
Pro Arg Trp Cys Pro Arg Gly Asp Leu Ala Pro Ser Thr Arg Ile His
                325                 330                 335     
Leu Ala Ala Thr Pro Gly Gln Leu Gln Pro Leu Asn Pro Ala Ser Lys
            340                 345                 350         
Cys Cys Gly Gln Ser Pro Thr Gln Pro Thr Arg Cys Pro Ser Arg His
        355                 360                 365             
Arg Gly Leu Glu Gly Arg Glu Thr Arg Arg Cys Pro Pro Gly Ser Ser
    370                 375                 380                 
Ala Leu Ala Pro Ser Pro Pro Arg Arg Cys Glu Phe Gln His Arg Thr
385                 390                 395                 400 
Gln Ala Ser Arg Cys Arg Leu Cys His Phe Ala Lys Gly Gly Arg Gly
                405                 410                 415     
Glu Arg Lys Glu Arg Gly Glu Gly Ala Glu Glu Thr Asn Pro Asp His
            420                 425                 430         
Arg Arg Arg Lys Lys Pro Phe Ser Lys Gln Ser Leu Leu Ser Ala Ser
        435                 440                 445             
His Pro Arg Cys Tyr Thr Val Lys Arg His
    450                 455             


<210> 2859
<211> 1398
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 731, 732, 733, 734, 735, 736, 737, 738, 739, 740, 741, 742,
743, 744, 745, 746, 747, 748, 749, 750, 751, 752, 753, 754,
755, 756, 757, 758, 759, 760, 761, 762, 763, 764, 765, 766,
767, 768, 769, 770, 771, 772, 773, 774, 775, 776, 777
<223> Xaa = Any Amino Acid

<221> VARIANT        
<222> 778, 779, 780, 781, 782, 783, 784, 785, 786, 787, 788, 789,
790, 791, 792, 793, 794
<223> Xaa = Any Amino Acid

<400> 2859
Met Ala Tyr Ser Trp Gln Thr Asp Pro Asn Pro Asn Glu Ser His Glu
 1               5                  10                  15      
Lys Gln Tyr Glu His Gln Glu Phe Leu Phe Val Asn Gln Pro His Ser
            20                  25                  30          
Ser Ser Gln Val Ser Leu Gly Phe Asp Gln Ile Val Asp Glu Ile Ser
        35                  40                  45              
Gly Lys Ile Pro His Tyr Glu Ser Glu Ile Asp Glu Asn Thr Phe Phe
    50                  55                  60                  
Val Pro Thr Ala Pro Lys Trp Asp Ser Thr Gly His Ser Leu Asn Glu
65                  70                  75                  80  
Ala His Gln Ile Ser Leu Asn Glu Phe Thr Ser Lys Ser Arg Glu Leu
                85                  90                  95      
Ser Trp His Gln Val Ser Lys Ala Pro Ala Ile Gly Phe Ser Pro Ser
            100                 105                 110         
Val Leu Pro Lys Pro Gln Asn Thr Asn Lys Glu Cys Ser Trp Gly Ser
        115                 120                 125             
Pro Ile Gly Lys His His Gly Ala Asp Asp Ser Arg Phe Ser Ile Leu
    130                 135                 140                 
Ala Pro Ser Phe Thr Ser Leu Asp Lys Ile Asn Leu Glu Lys Glu Leu
145                 150                 155                 160 
Glu Asn Glu Asn His Asn Tyr His Ile Gly Phe Glu Ser Ser Ile Pro
                165                 170                 175     
Pro Thr Asn Ser Ser Phe Ser Ser Asp Phe Met Pro Lys Glu Glu Asn
            180                 185                 190         
Lys Arg Ser Gly His Val Asn Ile Val Glu Pro Ser Leu Met Leu Leu
        195                 200                 205             
Lys Gly Ser Leu Gln Pro Gly Met Trp Glu Ser Thr Trp Gln Lys Asn
    210                 215                 220                 
Ile Glu Ser Ile Gly Cys Ser Ile Gln Leu Val Glu Val Pro Gln Ser
225                 230                 235                 240 
Ser Asn Thr Ser Leu Ala Ser Phe Cys Asn Lys Val Lys Lys Ile Arg
                245                 250                 255     
Glu Arg Tyr His Ala Ala Asp Val Asn Phe Asn Ser Gly Lys Ile Trp
            260                 265                 270         
Ser Thr Thr Thr Ala Phe Pro Tyr Gln Leu Phe Ser Lys Thr Lys Phe
        275                 280                 285             
Asn Ile His Ile Phe Ile Asp Asn Ser Thr Gln Pro Leu His Phe Met
    290                 295                 300                 
Pro Cys Ala Asn Tyr Leu Val Lys Asp Leu Ile Ala Glu Ile Leu His
305                 310                 315                 320 
Phe Cys Thr Asn Asp Gln Leu Leu Pro Lys Asp His Ile Leu Ser Val
                325                 330                 335     
Cys Gly Ser Glu Glu Phe Leu Gln Asn Asp His Cys Leu Gly Ser His
            340                 345                 350         
Lys Met Phe Gln Lys Asp Lys Ser Val Ile Gln Leu His Leu Gln Lys
        355                 360                 365             
Ser Arg Glu Ala Pro Gly Lys Leu Ser Arg Lys His Glu Glu Asp His
    370                 375                 380                 
Ser Gln Phe Tyr Leu Asn Gln Leu Leu Glu Phe Met His Ile Trp Lys
385                 390                 395                 400 
Val Ser Arg Gln Cys Leu Leu Thr Leu Ile Arg Lys Tyr Asp Phe His
                405                 410                 415     
Leu Lys Tyr Leu Leu Lys Thr Gln Glu Asn Val Tyr Asn Ile Ile Glu
            420                 425                 430         
Glu Val Lys Lys Ile Cys Ser Val Leu Gly Cys Val Glu Thr Lys Gln
        435                 440                 445             
Ile Thr Asp Ala Val Asn Glu Leu Ser Leu Ile Leu Gln Arg Lys Gly
    450                 455                 460                 
Glu Asn Phe Tyr Gln Ser Ser Glu Thr Ser Ala Lys Gly Leu Ile Glu
465                 470                 475                 480 
Lys Val Thr Thr Glu Leu Ser Thr Ser Ile Tyr Gln Leu Ile Asn Val
                485                 490                 495     
Tyr Cys Asn Ser Phe Tyr Ala Asp Phe Gln Pro Val Asn Val Pro Arg
            500                 505                 510         
Cys Thr Ser Tyr Leu Asn Pro Gly Leu Pro Ser His Leu Ser Phe Thr
        515                 520                 525             
Val Tyr Ala Ala His Asn Ile Pro Glu Thr Trp Val His Arg Ile Asn
    530                 535                 540                 
Phe Pro Leu Glu Ile Lys Ser Leu Pro Arg Glu Ser Met Leu Thr Val
545                 550                 555                 560 
Lys Leu Phe Gly Ile Ala Cys Ala Thr Asn Asn Ala Asn Leu Leu Ala
                565                 570                 575     
Trp Thr Cys Leu Pro Leu Phe Pro Lys Glu Lys Ser Ile Leu Gly Ser
            580                 585                 590         
Met Leu Phe Ser Met Thr Leu Gln Ser Glu Pro Pro Val Glu Met Ile
        595                 600                 605             
Thr Pro Gly Val Trp Asp Val Ser Gln Pro Ser Pro Val Thr Leu Gln
    610                 615                 620                 
Ile Asp Phe Pro Ala Thr Gly Trp Glu Tyr Met Lys Pro Asp Ser Glu
625                 630                 635                 640 
Glu Asn Arg Ser Asn Leu Glu Glu Pro Leu Lys Glu Cys Ile Lys His
                645                 650                 655     
Ile Ala Arg Leu Ser Gln Lys Gln Thr Pro Leu Leu Leu Ser Glu Glu
            660                 665                 670         
Lys Lys Arg Tyr Leu Trp Phe Tyr Arg Phe Tyr Cys Asn Asn Glu Asn
        675                 680                 685             
Cys Ser Leu Pro Leu Val Leu Gly Ser Ala Pro Gly Trp Asp Glu Arg
    690                 695                 700                 
Thr Val Ser Glu Met His Thr Ile Leu Arg Arg Trp Thr Phe Ser Gln
705                 710                 715                 720 
Pro Leu Glu Ala Leu Gly Leu Leu Thr Ser Xaa Xaa Xaa Xaa Xaa Xaa
                725                 730                 735     
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            740                 745                 750         
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
        755                 760                 765             
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    770                 775                 780                 
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Leu Lys Asn Ala Glu
785                 790                 795                 800 
Asn Glu Ala Tyr Phe Lys Ser Trp Tyr Gln Lys Leu Leu Ala Ala Leu
                805                 810                 815     
Gln Phe Cys Ala Gly Lys Ala Leu Asn Asp Glu Phe Ser Lys Glu Gln
            820                 825                 830         
Lys Leu Ile Lys Ile Leu Gly Asp Ile Gly Glu Arg Val Lys Ser Ala
        835                 840                 845             
Ser Asp His Gln Arg Gln Glu Val Leu Lys Lys Glu Ile Gly Arg Leu
    850                 855                 860                 
Glu Glu Phe Phe Gln Asp Val Asn Thr Cys His Leu Pro Leu Asn Pro
865                 870                 875                 880 
Ala Leu Cys Ile Lys Gly Ile Asp His Asp Ala Cys Ser Tyr Phe Thr
                885                 890                 895     
Ser Asn Ala Leu Pro Leu Lys Ile Thr Phe Ile Asn Ala Asn Pro Met
            900                 905                 910         
Gly Lys Asn Ile Ser Ile Ile Phe Lys Ala Gly Asp Asp Leu Arg Gln
        915                 920                 925             
Asp Met Leu Val Leu Gln Leu Ile Gln Val Met Asp Asn Ile Trp Leu
    930                 935                 940                 
Gln Glu Gly Leu Asp Met Gln Met Ile Ile Tyr Arg Cys Leu Ser Thr
945                 950                 955                 960 
Gly Lys Asp Gln Gly Leu Val Gln Met Val Pro Asp Ala Val Thr Leu
                965                 970                 975     
Ala Lys Ile His Arg His Ser Gly Leu Ile Gly Pro Leu Lys Glu Asn
            980                 985                 990         
Thr Ile Lys Lys Trp Phe Ser Gln His Asn His Leu Lys Ala Asp Tyr
        995                 1000                1005            
Glu Lys Ala Leu Arg Asn Phe Phe Tyr Ser Cys Ala Gly Trp Cys Val
    1010                1015                1020                
Val Thr Phe Ile Leu Gly Val Cys Asp Arg His Asn Asp Asn Ile Met
1025                1030                1035                1040
Leu Thr Lys Ser Gly His Met Phe His Ile Asp Phe Gly Lys Phe Leu
                1045                1050                1055    
Gly His Ala Gln Thr Phe Gly Gly Ile Lys Arg Asp Arg Ala Pro Phe
            1060                1065                1070        
Ile Phe Thr Ser Glu Met Glu Tyr Phe Ile Thr Glu Gly Gly Lys Asn
        1075                1080                1085            
Pro Gln His Phe Gln Asp Phe Val Glu Leu Cys Cys Arg Ala Tyr Asn
    1090                1095                1100                
Ile Ile Arg Lys His Ser Gln Leu Leu Leu Asn Leu Leu Glu Met Met
1105                1110                1115                1120
Leu Tyr Ala Gly Leu Pro Glu Leu Ser Gly Ile Gln Asp Leu Lys Tyr
                1125                1130                1135    
Val Tyr Asn Asn Leu Arg Pro Gln Asp Thr Asp Leu Glu Ala Thr Ser
            1140                1145                1150        
His Phe Thr Lys Lys Ile Lys Glu Ser Leu Glu Cys Phe Pro Val Lys
        1155                1160                1165            
Leu Asn Asn Leu Ile His Thr Leu Ala Gln Met Ser Ala Ile Ser Pro
    1170                1175                1180                
Ala Lys Ser Thr Ser Gln Thr Phe Pro Gln Glu Ser Cys Leu Leu Ser
1185                1190                1195                1200
Thr Thr Arg Ser Ile Glu Arg Ala Thr Ile Leu Gly Phe Ser Lys Lys
                1205                1210                1215    
Ser Ser Asn Leu Tyr Leu Ile Gln Val Thr His Ser Asn Asn Glu Thr
            1220                1225                1230        
Ser Leu Thr Glu Lys Ser Phe Glu Gln Phe Ser Lys Leu His Ser Gln
        1235                1240                1245            
Leu Gln Lys Gln Phe Ala Ser Leu Thr Leu Pro Glu Phe Pro His Trp
    1250                1255                1260                
Trp His Leu Pro Phe Thr Asn Ser Asp His Arg Arg Phe Arg Asp Leu
1265                1270                1275                1280
Asn His Tyr Met Glu Gln Ile Leu Asn Val Ser His Glu Val Thr Asn
                1285                1290                1295    
Ser Asp Cys Val Leu Ser Phe Phe Leu Ser Glu Ala Val Gln Gln Thr
            1300                1305                1310        
Val Glu Glu Ser Ser Pro Val Tyr Leu Gly Asn Glu Lys Phe Pro Asp
        1315                1320                1325            
Lys Lys Pro Lys Val Gln Leu Val Ile Ser Tyr Glu Asp Val Lys Leu
    1330                1335                1340                
Thr Ile Leu Val Lys His Met Lys Asn Ile His Leu Pro Asp Gly Ser
1345                1350                1355                1360
Ala Pro Ser Ala His Val Glu Phe Tyr Leu Leu Pro Tyr Pro Ser Glu
                1365                1370                1375    
Val Arg Arg Arg Lys Thr Lys Ser Val Pro Lys Cys Thr Asp Pro Thr
            1380                1385                1390        
Tyr Asn Glu Ser Ser Ile
        1395            


<210> 2860
<211> 650
<212> PRT
<213> Homo sapiens

<400> 2860
Met Ser Leu Val Ala Leu Leu Lys Asp Ser Ala Asn Ile Leu Leu Tyr
 1               5                  10                  15      
Gly Lys Thr Asn Met Tyr Cys His Leu Gly Ser Ile Tyr Tyr Ser Phe
            20                  25                  30          
Tyr Glu Ile Ile Ile Pro Lys Arg Leu Thr Val Gln Gly Gly Asp Ser
        35                  40                  45              
Pro Val Glu Gly Leu Ser Tyr Leu Leu Leu Met Gln Gly Gln Lys His
    50                  55                  60                  
Leu Val His Leu Lys Val Lys Arg Asn His Phe Val Asn Asn Phe Pro
65                  70                  75                  80  
Val Tyr Ser Tyr His Asn Gly Leu Leu Gly Gln Glu Ser Pro Phe Ile
                85                  90                  95      
Ser His Asp Cys His Tyr Glu Gly Tyr Ile Glu Gly Val Ser Gln Gly
            100                 105                 110         
His Ile Leu Leu Ile Lys Glu Glu Lys Ser Tyr Ser Ile Glu Pro Met
        115                 120                 125             
Asp Ser Ser Arg Arg Phe Glu His Val Leu Tyr Thr Met Ala His Gln
    130                 135                 140                 
Ala Trp Gln Gln Gly Ser Arg Lys Pro His Asp Leu Gln Ala Leu Ser
145                 150                 155                 160 
Tyr Leu Trp Ser His Lys Lys Tyr Val Glu Met Phe Val Val Val Asn
                165                 170                 175     
Asn Gln Arg Phe Gln Met Trp Gly Ser Asn Val Asn Glu Thr Val Gln
            180                 185                 190         
Thr Val Val Asp Val Ile Ala Leu Ala Asn Ser Phe Thr Arg Gly Ile
        195                 200                 205             
Asn Thr Glu Val Val Leu Ala Gly Met Glu Ile Trp Thr Glu Gly Asp
    210                 215                 220                 
Leu Ile Asp Val Thr Val Asp Leu Gln Ile Thr Leu Arg Asn Phe Asn
225                 230                 235                 240 
His Trp Arg Gln Glu Met Leu Phe His Arg Ala Lys His Asp Val Ala
                245                 250                 255     
His Met Ile Val Gly His His Pro Gly Gln Asn Met Gly Gln Ala Phe
            260                 265                 270         
Leu Ser Gly Ala Cys Ser Ser Gly Phe Ala Ala Ala Val Glu Ser Phe
        275                 280                 285             
His His Glu Asp Val Leu Leu Phe Ala Ala Leu Met Ala His Glu Leu
    290                 295                 300                 
Gly His Asn Leu Gly Ile Gln His Asp His Ser Ala Cys Phe Cys Lys
305                 310                 315                 320 
Asp Lys His Phe Cys Leu Met His Glu Asn Ile Thr Lys Glu Ser Gly
                325                 330                 335     
Phe Ser Ser Cys Ser Ser Asp Tyr Phe Tyr Gln Phe Leu Arg Glu His
            340                 345                 350         
Lys Gly Ala Cys Leu Phe Asn Lys Pro Arg Pro Arg Gly Arg Lys Arg
        355                 360                 365             
Arg Asp Ser Ala Cys Gly Asn Gly Val Val Glu Asp Thr Glu Gln Cys
    370                 375                 380                 
Asp Cys Gly Ser Leu Cys Gln His His Ala Cys Cys Asp Glu Asn Cys
385                 390                 395                 400 
Ile Leu Lys Ala Lys Ala Glu Cys Ser Asp Gly Pro Cys Cys His Lys
                405                 410                 415     
Cys Lys Phe His Arg Lys Gly Tyr Pro Cys Cys Pro Ser Ser Arg Ser
            420                 425                 430         
Cys Asp Leu Pro Glu Phe Cys Asn Gly Thr Ser Ala Leu Cys Pro Asn
        435                 440                 445             
Asn Arg His Lys Gln Asp Gly Ser Lys Cys His Thr Ile Tyr Glu Cys
    450                 455                 460                 
Leu Lys Val His Cys Met Asp Pro Asn Asn Gln Cys Leu Gln Leu Tyr
465                 470                 475                 480 
Gly Tyr Gly Ala Lys Ser Ala Ser Gln Glu Cys Tyr Asn Ser Met Asn
                485                 490                 495     
Ser Lys Gly Asp Gln Phe Gly Asn Cys Gly Ile Ser Thr Ser Pro Gly
            500                 505                 510         
Ser Gln Tyr Val Arg Cys Ser Asp Gly Asn Ile Phe Cys Gly Lys Leu
        515                 520                 525             
Ile Cys Ser Gly Ile Thr Gly Leu Pro Lys Ile Asn Leu Gln His Thr
    530                 535                 540                 
Met Ile Gln Val Pro Gln Gly Asp Gly Ser Cys Trp Ser Met Asp Ala
545                 550                 555                 560 
Tyr Met Ser Thr Asp Ile Pro Asp Glu Gly Asp Val His Asn Gly Thr
                565                 570                 575     
Tyr Cys Ala Pro Asn Lys Val Cys Leu Asn Ser Ala Cys Thr Asp Lys
            580                 585                 590         
Thr Pro Val Ile Ser Ala Cys Asn Pro Glu Lys Thr Cys Asn Gly Lys
        595                 600                 605             
Gly Val Cys Asn Asp Leu Gly His Cys His Cys Asn Glu Gly His Ala
    610                 615                 620                 
Pro Pro Asp Cys Val Thr Ala Gly Ser Gly Gly Ser Val Asp Ser Gly
625                 630                 635                 640 
Pro Pro Gly Met Ser Asp Gly Asn Ser Ser
                645                 650 


<210> 2861
<211> 146
<212> PRT
<213> Homo sapiens

<400> 2861
Met Pro Thr Pro Arg Val Gly Pro Gly Gln Pro Ser Leu Leu Phe Gly
 1               5                  10                  15      
Leu Ser Gln Leu Ser Asn Pro Thr Gly Gly Gly Val Leu Arg Gly Pro
            20                  25                  30          
Gly Ser Gly Pro Asn Pro Leu Cys Lys Pro Trp Ala Val Ala Glu Gly
        35                  40                  45              
Arg Ser Ser Ala Lys Gly Gly Arg Leu Gly Ala Asn Leu Pro Trp Lys
    50                  55                  60                  
Tyr Met Glu Met Leu Pro Asp Leu Ser Ser His Pro Ser Gln Asp Ser
65                  70                  75                  80  
Glu Ser Phe Ser Asp Pro Glu Glu Tyr Gln Gly Gly Asn Gly Lys Phe
                85                  90                  95      
Asn Ala His Ser Phe Leu Asp Val Gln Lys Pro Asn Glu Val Leu Leu
            100                 105                 110         
Ser Leu Ser Ser Leu Ser Gly Ala Leu Ile Glu Pro His Ser Gln Pro
        115                 120                 125             
His Arg Lys Asp Leu Glu Ala Leu Ser Thr Asp Asp Ala Val Val Pro
    130                 135                 140                 
Gln Lys
145     


<210> 2862
<211> 109
<212> PRT
<213> Homo sapiens

<400> 2862
Met Leu Ser Ala Ala Ala Arg Gln Arg Val Tyr Leu Cys Pro Lys Gly
 1               5                  10                  15      
Gln Ala Gly Gly Pro Gly Glu Gln Lys Gly Ala Gln Ser Cys Trp Arg
            20                  25                  30          
Arg Trp Gly Val Glu Ile Ile Ile Met Ser Glu Ile Ile Ile Ala Val
        35                  40                  45              
Asn Ala Gln Arg Leu Gly Cys Ser Ala Glu Ala Gly Gly Gly Leu Gln
    50                  55                  60                  
Arg Leu Leu Thr Gly Arg Thr Gly Gly Val Asp Pro Ala Glu Cys Leu
65                  70                  75                  80  
Ala Leu Arg Ala Ala Gly Leu Ala Thr Arg Phe Ser Asp Thr Thr Pro
                85                  90                  95      
Glu Asn Gly Thr Glu Ile Ile Ala Cys Ser Arg Asn Val
            100                 105                 


<210> 2863
<211> 221
<212> PRT
<213> Homo sapiens

<400> 2863
Met Lys Lys Arg Leu Ser Val Ile Gly Ile Leu Leu Leu Thr Ala Ser
 1               5                  10                  15      
Leu Ser Leu Gly Ser His Met Trp Asn Ala Thr Asp Leu Tyr Ala Val
            20                  25                  30          
Leu Asn His Pro Ile Tyr Gln Arg Ala Leu Trp Gln Val Tyr Leu Thr
        35                  40                  45              
Thr Ala Ser Gly Ser Ile Gln Pro Gln Ile Tyr Asn Ser Gly Ile Gly
    50                  55                  60                  
His Glu Ser Ser Arg Thr Ile Pro Arg Ser Gly Ser Ala Ser Ser Arg
65                  70                  75                  80  
Ala Tyr Gly Leu Ala His Lys Lys Pro Cys Ser Leu Glu Lys His Ser
                85                  90                  95      
His Tyr Gln Pro Leu Phe Gln Ser Ser Lys Ile Val Met Val Ala Pro
            100                 105                 110         
Ile Pro Gly Pro Leu Ala Arg Lys Thr Arg Leu Leu Leu Glu Phe Cys
        115                 120                 125             
Cys Pro Cys Asn Leu Ala Glu Asp Ser Ser Ser Asp Glu Thr Gly Cys
    130                 135                 140                 
Ile Gln Gly Gly Met Asp Lys Asp Pro Tyr Gly His Gln Arg Gln Leu
145                 150                 155                 160 
Leu Ser Ile Ile Glu Asn Pro Asp Val Pro Lys Ala Val Phe Trp Pro
                165                 170                 175     
Ser Gly Asp His Val Glu Arg Pro Leu Val Trp Asp Val Asp Asp Ile
            180                 185                 190         
Asn Ser Asn Ile Glu Phe Asp Pro Val His Val Cys Asp Leu Ile Gln
        195                 200                 205             
Gln Cys Ala Phe Thr Ile Leu Tyr Ser Ser Ser Ile Ala
    210                 215                 220     


<210> 2864
<211> 181
<212> PRT
<213> Homo sapiens

<400> 2864
Met Pro Thr Pro Leu Leu Pro Leu Trp Ala Asn Ser Thr Gly Ala Leu
 1               5                  10                  15      
Ser Gly Arg Leu Val Val Pro Gln Cys Val Trp Ala Val Ser Tyr Thr
            20                  25                  30          
Leu Val Phe Ala Leu His Ser Arg Arg Ile Pro Leu Ile Pro Ala His
        35                  40                  45              
Ala Phe Glu Ser Ala Phe Gly Gly Arg Trp Arg Gln His Pro Trp Leu
    50                  55                  60                  
Gly Lys Gly Ser Leu Pro Thr Asp Ser Asp Thr Leu Phe Met Glu Asn
65                  70                  75                  80  
His Gly Ala Leu Trp Lys Gly Val Val Lys Gly Arg Ser Ser Glu Tyr
                85                  90                  95      
Lys Lys Ala Arg Lys Thr Ser Ala Gln Ala Ile Glu Arg Glu Thr Gly
            100                 105                 110         
Met Ser Glu Phe Glu Gly Leu Gly Val Lys His Phe Gln Leu Ala Ser
        115                 120                 125             
Arg Gly Leu Met Lys Glu Lys Pro Ala Val Gly Gly Glu Ala Gln Gly
    130                 135                 140                 
Val Phe Leu Gln Asp Thr Arg Lys Val Val Tyr Lys Glu Ala Glu Lys
145                 150                 155                 160 
Ala Gly Asp Gly Phe Arg Ala Cys Gly Ser Gly Pro Ser Gly Gly Arg
                165                 170                 175     
Glu Glu Ser Glu Gly
            180     


<210> 2865
<211> 205
<212> PRT
<213> Homo sapiens

<400> 2865
Met Gly Leu Val Ile Thr Glu Val Glu Gln Glu Pro Ser Phe Ser Asp
 1               5                  10                  15      
Ile Glu Ser Leu Val Val Trp Cys Met Ala Val Gly Ile Ser Tyr Ile
            20                  25                  30          
Ser Val Tyr Asp His Gln Gly Ile Phe Lys Arg Asn Asn Ser Arg Leu
        35                  40                  45              
Met Asp Gly Ile Leu Lys Gln Gln Gln Glu Leu Leu Gly Leu Asp Cys
    50                  55                  60                  
Ser Lys Cys Ser Pro Glu Phe Ala Asn Ser Asn Asp Lys Asp Asp Gln
65                  70                  75                  80  
Val Leu Asn Cys His Leu Ala Val Lys Val Leu Leu Pro Glu Asp Gly
                85                  90                  95      
Lys Ala Asp Ile Val Arg Ala Ala Gln Asp Phe Cys Gln Ala Ser Glu
            100                 105                 110         
Ser Arg Ala Phe Gly Leu Gln Ala Glu Gln Arg Gly Gln Gln Arg Gly
        115                 120                 125             
Gly Ser Val Ala Gln Leu Ala Gly Ser Arg Arg Thr Pro Gly Arg Pro
    130                 135                 140                 
Gly Ala Arg Arg Leu Ser Ser His Arg Ser Gly Leu Pro Arg Pro Ser
145                 150                 155                 160 
Arg Leu Leu Ser His Pro His Gly Gly Arg Ala Ala Glu Arg Gly Val
                165                 170                 175     
Arg Ile Ala Lys Leu Leu Pro Pro Arg Pro Pro Arg Ala Gln Ala Ala
            180                 185                 190         
Arg Ala Ala Ser Thr Ala Gly Gly Pro Arg Ala Trp Ala
        195                 200                 205 


<210> 2866
<211> 121
<212> PRT
<213> Homo sapiens

<400> 2866
Met Glu Phe Val Lys Gly Met Lys Met Val Ser Gly Lys Arg Lys Gly
 1               5                  10                  15      
Glu Glu Glu His Glu Gln Lys Asp Asp Asn Val Arg Lys Cys Leu Ser
            20                  25                  30          
Arg Phe Glu Ile Ala Val Leu Leu Arg Arg Leu Lys Ala Arg Ile Gly
        35                  40                  45              
Glu Val Glu Ile Ile Ser Ser Asp Met Leu Val Glu Ala Ser Met Gly
    50                  55                  60                  
Lys Thr Asn Ser Gly Leu Glu Glu Asp Ala Lys Arg Val Leu Gly Leu
65                  70                  75                  80  
Tyr Gly Asn Thr Asp Gln Gly Pro Glu Ser Arg Arg Leu Pro Trp Leu
                85                  90                  95      
Phe Arg Gln Val Cys Phe Pro Ala Asp Val Cys Thr Gly Arg Trp Val
            100                 105                 110         
Pro Asn Cys Ser Glu Ser Ser Gln Ser
        115                 120     


<210> 2867
<211> 152
<212> PRT
<213> Homo sapiens

<400> 2867
Met Glu Ala Ser Leu Arg Ala Ala Pro Arg Thr Ile Ser Ser Gln Gly
 1               5                  10                  15      
Ser Ile Asn Gln Ser Gly Ser Gln Asn His Phe Arg Ser Arg Asn His
            20                  25                  30          
His Ser Glu Arg Leu Pro Glu Pro Phe Pro Val Thr Glu Ala Ala Leu
        35                  40                  45              
Arg Ala Ala Pro Arg Thr Ile Ser Gly His Gly Ser Gly Thr Gln Ser
    50                  55                  60                  
Gly Ser Gln Asn His Phe Pro Ser Arg Lys Arg His Ser Glu Arg Leu
65                  70                  75                  80  
Pro Glu Pro Phe Pro Val Thr Glu Ala Ala Leu Arg Ala Ala Pro Arg
                85                  90                  95      
Thr Ile Ser Arg His Gly Ser Gly Thr Gln Ser Gly Ser Gln Asn His
            100                 105                 110         
Phe Arg Ser Arg Lys Arg His Ser Glu Arg Leu Pro Glu Pro Phe Pro
        115                 120                 125             
Val Thr Glu Thr Ala Leu Arg Ala Ala Pro Arg Thr Ile Ser Gly His
    130                 135                 140                 
Gly Ser Val Thr Gln Ser Arg Phe
145                 150         


<210> 2868
<211> 287
<212> PRT
<213> Homo sapiens

<400> 2868
Met Arg Pro Pro Ala Cys Trp Trp Leu Leu Ala Pro Pro Ala Leu Leu
 1               5                  10                  15      
Ala Leu Leu Thr Cys Ser Leu Ala Phe Gly Leu Ala Ser Glu Asp Thr
            20                  25                  30          
Lys Lys Glu Val Lys Gln Ser Gln Asp Leu Glu Lys Ser Gly Ile Ser
        35                  40                  45              
Arg Lys Asn Asp Ile Asp Leu Lys Gly Ile Val Phe Val Ile Gln Ser
    50                  55                  60                  
Gln Ser Asn Ser Phe His Ala Lys Arg Ala Glu Gln Leu Lys Lys Ser
65                  70                  75                  80  
Ile Leu Lys Gln Ala Ala Asp Leu Thr Gln Glu Leu Pro Ser Val Leu
                85                  90                  95      
Leu Leu His Gln Leu Ala Lys Gln Glu Gly Ala Trp Thr Ile Leu Pro
            100                 105                 110         
Leu Leu Pro Gln Tyr Val Phe Ser Val Thr Tyr Ser Arg Asn Ser Ser
        115                 120                 125             
Trp Ile Phe Phe Cys Glu Glu Glu Thr Arg Ile Gln Ile Pro Lys Leu
    130                 135                 140                 
Leu Glu Thr Leu Arg Arg Tyr Asp Pro Ser Lys Glu Trp Phe Leu Gly
145                 150                 155                 160 
Lys Ala Leu His Asp Glu Glu Ala Thr Ile Ile His His Tyr Ala Phe
                165                 170                 175     
Ser Glu Asn Pro Thr Val Phe Lys Tyr Pro Asp Phe Ala Ala Gly Trp
            180                 185                 190         
Ala Leu Ser Ile Pro Leu Val Asn Lys Leu Thr Lys Arg Leu Lys Ser
        195                 200                 205             
Glu Ser Leu Lys Ser Asp Phe Thr Ile Asp Leu Lys His Glu Ile Ala
    210                 215                 220                 
Leu Tyr Ile Trp Asp Lys Gly Gly Gly Pro Pro Leu Thr Pro Val Pro
225                 230                 235                 240 
Glu Phe Cys Thr Asn Asp Val Asp Phe Tyr Cys Ala Thr Thr Phe His
                245                 250                 255     
Ser Phe Leu Pro Leu Cys Arg Lys Pro Val Lys Lys Lys Asp Ile Phe
            260                 265                 270         
Val Ala Val Lys Thr Cys Lys Lys Phe His Gly Asp Arg Ile Asn
        275                 280                 285         


<210> 2869
<211> 731
<212> PRT
<213> Homo sapiens

<400> 2869
Met His His Pro Pro Arg Ala Gly Gln Ala Glu Gly Gln Gln Gly Lys
 1               5                  10                  15      
Gly Asp Arg Lys Pro Lys Trp Pro Pro Pro Lys Pro Pro Pro Ser Phe
            20                  25                  30          
Ala Ile Arg Asn Ser Asp Ser Ser Cys Gln Gly Gly Pro Ser Pro Ile
        35                  40                  45              
Gln Ala Ser Glu Leu Arg Ala Ser Lys Ser Gln Val Leu Gly Ala Ser
    50                  55                  60                  
Ala Gly Gly Gly Pro Ile Lys Leu Lys Pro Pro Leu Gly Thr Ser Arg
65                  70                  75                  80  
Gly Cys Trp Ser Pro Ala Gln Gln Gln Arg Arg Pro Arg His Leu Gly
                85                  90                  95      
Gln Gly Glu Lys Ser Pro His Ser Ser Gln Ala Thr Ala His Gly Lys
            100                 105                 110         
Glu Gln Leu Ile Lys Pro Pro Arg Gln Arg Ala Gly Leu Gln Pro Arg
        115                 120                 125             
Ala Ala Ala Val Ser Gly Ala Asp Asn Arg Ser Arg Lys Gly Pro Pro
    130                 135                 140                 
Ala Arg Gln Gln Pro Ser Gln Val Leu Leu Ser Arg Thr Phe Pro Arg
145                 150                 155                 160 
Leu Val Gln Pro Ile Arg Ala Gly Gly Lys Glu Arg Ala Arg Cys Ser
                165                 170                 175     
Ser Leu Glu Thr Gly Trp Pro His Leu Ala Ala Pro Trp Arg Arg Arg
            180                 185                 190         
Ser Gln Gly Gln Pro Gly Ser Val Ala Ala Pro Thr Ser Ser Pro Pro
        195                 200                 205             
Arg Gly Ala Ala Ala Gly Thr Glu Asp Leu Arg Trp Ser Pro Pro Ser
    210                 215                 220                 
Ala Tyr Pro Leu Pro Gly Ser Ser Gly Pro Ser Pro Pro Cys Ser Ser
225                 230                 235                 240 
His His Ser Asp Phe Gln Arg Pro Asp His Pro Ala Trp Leu Pro Pro
                245                 250                 255     
Gly Thr Arg Glu Ser Pro Ala Asp Ser His Ser Pro Gln Gln His Lys
            260                 265                 270         
Leu Arg Phe His Gly Pro Asp Glu Gln Ala Glu Ala Asp Thr Thr Lys
        275                 280                 285             
Ala Arg Gly Gln Trp Phe Thr Ser Leu Lys Leu Lys Ser Ser Pro Lys
    290                 295                 300                 
Cys Pro Ser Ser Thr Pro Gly Thr Pro Lys Lys Gln Glu Arg Gln Asp
305                 310                 315                 320 
Glu His Lys Asp Val Pro Ser Thr His His Met Leu Asn His Arg Glu
                325                 330                 335     
Ser Arg Arg Gln His Arg Leu Ser Arg Glu Glu Lys Ala Gln Gly Gln
            340                 345                 350         
Ala Pro Phe Ser Asp Gln Glu Arg Gln Ser Pro Gly Ala Pro Thr Gly
        355                 360                 365             
Ala Gly Arg Gln Cys Pro Pro Pro Leu Arg Pro Gln Thr Gly His Gln
    370                 375                 380                 
Ser Ser Glu Ser Leu Cys Lys Leu Pro Ala Cys Ile Val Pro Gly Thr
385                 390                 395                 400 
Met Val Pro Ala Pro Ser Lys Ala Gly Arg Pro Thr Gly Trp Lys Ser
                405                 410                 415     
Arg Arg Thr Pro Pro Leu Gln Ala Pro Ala Pro Gly Ala Gly Ala Trp
            420                 425                 430         
Gly Thr Gln Arg Ala Pro Thr Gln Phe Pro Met Gly Gly His Cys Leu
        435                 440                 445             
Ser Leu Ser Gln Glu Leu His Gln Leu Arg Val Ala Val Ala Ala Pro
    450                 455                 460                 
Ala Ala Ser Ala Gly Arg Val Ala Leu Leu Trp Ala Gly Pro Gly Ala
465                 470                 475                 480 
Phe Gly Ser Arg Ala Ala Ala Ala Trp Val Leu Val Gly Pro Gly Gly
                485                 490                 495     
Pro Gly Arg Ala Tyr Arg Gly Leu Arg Ser Ala Gln Arg Asp Ala Ala
            500                 505                 510         
Ala Asp His Gly Arg Gly Ala Gly Arg Ala Arg Gln Ala Leu Pro Ala
        515                 520                 525             
Thr Leu Ala Leu Arg Gly Arg Arg Gly Tyr Val Ile Arg Pro Arg Gly
    530                 535                 540                 
Ala Pro Met Ala Arg Pro Ser Arg Ser Glu Val Arg Arg Ala Cys Glu
545                 550                 555                 560 
Cys Arg Glu Glu Arg Gly Gly Ser Gly Val Arg Lys Arg Lys Gly Thr
                565                 570                 575     
Ala Pro Pro Pro Ala Ala Pro Leu Leu Arg Asp Thr His Ser Leu Tyr
            580                 585                 590         
Pro Val Pro Pro Pro Thr His Ala Thr Gln Lys His Ala Ala Val Gly
        595                 600                 605             
Ser Thr Gly Pro Ala Pro Leu Ala Ser His Thr Arg Asn Phe Ser Ala
    610                 615                 620                 
Ser Thr Ala Ala Ala Leu Arg Glu Ala Gln Ala His Ile Pro Tyr Pro
625                 630                 635                 640 
Gln Asn Thr Gly Cys Thr Arg Leu Glu Ser Pro Arg Gly Leu Thr Ile
                645                 650                 655     
Ser Gln Gly Pro Arg Pro Pro Thr Ser Pro Ile Leu Ala Arg Arg Lys
            660                 665                 670         
Ala His Pro Asn Arg Thr Thr Glu Arg Ala Gln Arg Asp Pro Gln Ser
        675                 680                 685             
Ala Pro Pro Leu Gln Asp Pro Asp Cys Ala Ala Thr Arg Gly Leu Pro
    690                 695                 700                 
Cys Pro Asp Pro Asp Ser Leu Arg Ala Gly Arg Phe Gly Leu Ala Ala
705                 710                 715                 720 
Gly His Asp Asp Phe Thr Phe Arg Val Arg Ser
                725                 730     


<210> 2870
<211> 165
<212> PRT
<213> Homo sapiens

<400> 2870
Met Asp Gly Met Thr Trp Glu Ile Val Ala Ser Leu Lys Leu Ile Gly
 1               5                  10                  15      
Ser Trp Gln Pro Lys Asn Pro Val Leu Gln Met Ala Arg Lys Leu Pro
            20                  25                  30          
Arg Lys Pro Leu Glu Asn Met Val Lys Asp Gly Glu Thr Arg Met Thr
        35                  40                  45              
Pro Trp Phe Leu Lys Arg Cys Leu Gly Ile Glu Val Arg Leu Met Arg
    50                  55                  60                  
Leu His Thr Val Pro Phe Arg Arg Ala Asp Thr His Glu Ile Ile Asn
65                  70                  75                  80  
His Gly Ser Leu Ala Gly Arg Gln Thr Gln Ser Trp Arg Arg Arg Pro
                85                  90                  95      
Gln Thr Arg Trp Ala Glu Arg Arg Gln His Arg Asp Leu Arg Glu Ala
            100                 105                 110         
Leu Gly Arg Asn Arg Gln Arg Trp Gly Leu Asp Ser Pro Gly Glu Arg
        115                 120                 125             
Lys Leu Leu Gly Gly Asp Gln Gly Leu Ala Phe Gly Pro Lys Pro Arg
    130                 135                 140                 
Thr Arg Asp Gln Leu Val Pro Gly Asn Ser Gly Ala Gln His Pro Thr
145                 150                 155                 160 
Thr Gly Ala Gly Ala
                165 


<210> 2871
<211> 1077
<212> PRT
<213> Homo sapiens

<400> 2871
Met Ser His Leu Gly Leu Pro Leu Gly Leu Ser His Leu Pro Thr Ala
 1               5                  10                  15      
Pro Arg Gly Arg Val Pro Gly Ile Cys Pro Pro Ser Trp Ala Leu Pro
            20                  25                  30          
Cys Lys Asp Gly Gly Arg Asn Ser Gly Arg Lys Gln Arg Thr Glu Trp
        35                  40                  45              
Ser Gly Glu Asn Pro Ala Pro Arg Leu Leu Leu Gly Leu Leu Arg Cys
    50                  55                  60                  
Ser Val Ala Arg Cys Phe Arg Gln Lys Leu Leu His Gln Gly Arg Ala
65                  70                  75                  80  
Arg Arg Leu Pro Pro Pro Arg Ala Gln Gly Pro Pro Ala Leu Ser Pro
                85                  90                  95      
Ser Ala Ala Ala Gly Arg Gly Gln Asp Ser Arg Ala Leu Gly Cys Lys
            100                 105                 110         
Val Leu Glu Tyr Pro Thr Ile Thr Gly His Pro Glu Trp Ala Gly Lys
        115                 120                 125             
Glu Gly Asp Asp Gly Gly Gly Met Glu Phe Pro Glu His Gly Gly Arg
    130                 135                 140                 
Leu Leu Gly Arg Leu Arg Gln Gln Arg Glu Leu Gly Phe Leu Cys Asp
145                 150                 155                 160 
Cys Thr Val Leu Val Gly Asp Ala Arg Phe Pro Ala His Arg Ala Val
                165                 170                 175     
Leu Ala Ala Cys Ser Val Tyr Phe His Leu Phe Tyr Arg Asp Arg Pro
            180                 185                 190         
Ala Gly Ser Arg Asp Thr Val Arg Leu Asn Gly Asp Ile Val Thr Ala
        195                 200                 205             
Pro Ala Phe Gly Arg Leu Leu Asp Phe Met Tyr Glu Gly Arg Leu Asp
    210                 215                 220                 
Leu Arg Ser Leu Pro Val Glu Asp Val Leu Ala Ala Ala Ser Tyr Leu
225                 230                 235                 240 
His Met Tyr Asp Ile Val Lys Val Cys Lys Gly Arg Leu Gln Glu Lys
                245                 250                 255     
Asp Arg Ser Leu Asp Pro Gly Asn Pro Ala Pro Gly Ala Glu Pro Ala
            260                 265                 270         
Gln Pro Pro Cys Pro Trp Pro Val Trp Thr Ala Asp Leu Cys Pro Ala
        275                 280                 285             
Ala Arg Lys Ala Lys Leu Pro Pro Phe Gly Val Lys Ala Ala Leu Pro
    290                 295                 300                 
Pro Arg Ala Ser Gly Pro Pro Pro Cys Gln Val Pro Glu Glu Ser Asp
305                 310                 315                 320 
Gln Ala Leu Asp Leu Ser Leu Lys Ser Gly Pro Arg Gln Glu Arg Val
                325                 330                 335     
His Pro Pro Cys Val Leu Gln Thr Pro Leu Cys Ser Gln Arg Gln Pro
            340                 345                 350         
Gly Ala Gln Pro Leu Val Lys Asp Glu Arg Asp Ser Leu Ser Glu Gln
        355                 360                 365             
Glu Glu Ser Ser Ser Ser Arg Ser Pro His Ser Pro Pro Lys Pro Pro
    370                 375                 380                 
Pro Val Pro Ala Ala Lys Gly Leu Val Val Gly Leu Gln Pro Leu Pro
385                 390                 395                 400 
Leu Ser Gly Glu Gly Ser Arg Glu Leu Glu Leu Gly Ala Gly Arg Leu
                405                 410                 415     
Ala Ser Glu Asp Glu Leu Gly Pro Gly Gly Pro Leu Cys Ile Cys Pro
            420                 425                 430         
Leu Cys Ser Lys Leu Phe Pro Ser Ser His Val Leu Gln Leu His Leu
        435                 440                 445             
Ser Ala His Phe Arg Glu Arg Asp Ser Thr Arg Ala Arg Leu Ser Pro
    450                 455                 460                 
Asp Gly Val Ala Pro Thr Cys Pro Leu Cys Gly Lys Thr Phe Ser Cys
465                 470                 475                 480 
Thr Tyr Thr Leu Lys Arg His Glu Arg Thr His Ser Gly Glu Lys Pro
                485                 490                 495     
Tyr Thr Cys Val Gln Cys Gly Lys Ser Phe Gln Tyr Ser His Asn Leu
            500                 505                 510         
Ser Arg His Thr Val Val His Thr Arg Glu Lys Pro His Ala Cys Arg
        515                 520                 525             
Trp Cys Glu Arg Arg Phe Thr Gln Ser Gly Asp Leu Tyr Arg His Val
    530                 535                 540                 
Arg Lys Phe His Cys Gly Leu Val Lys Ser Leu Leu Val Asn Tyr Ser
545                 550                 555                 560 
His Val Arg Lys Val Val Gly Val Arg Pro Asn Gly Ala Leu Gly Gly
                565                 570                 575     
Asn Arg Thr Leu Leu Gly Ser Gly Ser Arg Asn Pro Cys Gln Glu Gly
            580                 585                 590         
Leu Gly His Lys Ala Leu Gln Gly Val Ile Ser Pro Glu Pro Ser Leu
        595                 600                 605             
Ala Gly Ala Arg Pro Ser Phe Pro Asp Gln Met Gly Gln Gly Leu Tyr
    610                 615                 620                 
Met Cys Cys Lys Arg Gln His Ser Ala Leu Leu Thr Cys Glu Glu Pro
625                 630                 635                 640 
Gly Ala Asp Arg Gly Val Gly Gln Ser Arg Ser Pro Leu Cys Leu Phe
                645                 650                 655     
Ser Trp Thr Leu Ser Cys Pro Arg Cys Cys Pro Met His Cys Ser Pro
            660                 665                 670         
Ala Glu Val Arg Leu His His Gln Gln Val Gly Lys Glu Gly Pro Ala
        675                 680                 685             
Leu Gln Arg Leu Thr Pro Ser Ser Ser Leu Arg Gly Ser Arg Pro Thr
    690                 695                 700                 
Pro Val Ser Pro Ile Phe Ser Gln Gly Cys Ser Phe Gly His Pro Ile
705                 710                 715                 720 
Ser Phe Ile Ser His Pro Thr Arg Ala Pro His Ser Trp Val Cys Gly
                725                 730                 735     
Leu Ser Gln Val Ile Ser Arg Gly Arg Gly Ser Pro Gly Met Arg Thr
            740                 745                 750         
Asp Arg Pro Thr Ala Glu Tyr Ser His Asn Arg Ile Leu Cys Val Asp
        755                 760                 765             
Glu Arg Glu Glu Leu Ala Val His Pro Met Leu Met Lys Leu Pro Glu
    770                 775                 780                 
Leu Met Glu Arg Ser Leu Leu Gln Asp Cys Pro Leu Ser Leu Ala Pro
785                 790                 795                 800 
Pro Val His Leu Pro Ala Leu Leu Gly Leu Arg Ala Thr Ala Val Ser
                805                 810                 815     
Ser Gly Ser Gly Gly Ala Val Gly Ser Leu Val Leu Ser Leu Ser Gly
            820                 825                 830         
His Ser His Arg Ser Arg Pro Ser Ala Pro Gly Leu Pro Cys Pro Gly
        835                 840                 845             
Arg Leu Leu Val Ala Ala Gly Gly Leu Leu Val Arg Leu Leu Arg Ala
    850                 855                 860                 
Gly Ala Gly Ser Trp Ala Ser Pro Pro Ser His Arg Gly Leu Leu Leu
865                 870                 875                 880 
Pro Pro Ala Phe Ser Glu Leu Met Pro Arg Pro Asp Gly Arg Asp Lys
                885                 890                 895     
Gly Leu Leu Pro Asn Val Gly Cys Pro Asp Glu Arg Gly Asp Asp Ala
            900                 905                 910         
His His Leu Gly Tyr Phe Arg Met Trp Glu Pro Met Arg Ala Ala Gly
        915                 920                 925             
Thr Lys Leu Ser Pro Ala Ser Ser Ser His Trp Arg Leu Pro Ala Gly
    930                 935                 940                 
Thr Gly Gly Lys Gly Val Met Ser Gln Ala Glu His Ser Thr Gly Arg
945                 950                 955                 960 
Pro Met Glu Val His Gly Thr Ala His Val Cys Thr Leu Arg Pro Val
                965                 970                 975     
Leu Gly Asp Cys Pro Ser Leu Arg Glu Arg Ile Ser Asn Pro Lys Arg
            980                 985                 990         
Lys Lys Pro Gln Arg His Phe Pro Gln Lys Ser Glu Leu Cys Trp Ile
        995                 1000                1005            
Ser Pro Lys Arg Phe Leu Cys Arg Asp Leu Trp Pro Ala Glu Leu Pro
    1010                1015                1020                
Ser Pro Ala Val Ser Ser Ala Val Ser Gly Pro Thr Trp Pro Glu Gly
1025                1030                1035                1040
Ile Ser Ala Pro Val Phe Gly Lys Gln Thr His Val Pro Gln Arg Thr
                1045                1050                1055    
Gly Ser Gln Asp Cys His Ser Cys Asp Pro Thr Leu Pro Glu Trp Glu
            1060                1065                1070        
Arg Lys Ile Pro Pro
        1075        


<210> 2872
<211> 31
<212> PRT
<213> Homo sapiens

<400> 2872
Met Ala Ile Val Asn Ser Thr Cys Arg Tyr Leu Arg Ala Cys Ala Ala
 1               5                  10                  15      
Arg Val Pro Ala Leu Gly Arg Gly His Ser Glu Val Thr His Gly
            20                  25                  30      


<210> 2873
<211> 1427
<212> PRT
<213> Homo sapiens

<400> 2873
Met Ala Glu Glu Glu Glu Gly Thr Thr Gly Glu Leu Arg Ser Ala Glu
 1               5                  10                  15      
Pro Ala Pro Ala Asp Ser Arg His Pro Leu Thr Tyr Arg Lys Thr Thr
            20                  25                  30          
Asn Phe Ala Leu Asp Lys Phe Leu Asp Pro Ala Arg Pro Tyr Lys Cys
        35                  40                  45              
Thr Val Cys Lys Glu Ser Phe Thr Gln Lys Asn Ile Leu Leu Val His
    50                  55                  60                  
Tyr Asn Ser Val Ser His Leu His Lys Met Lys Lys Ala Ala Ile Asp
65                  70                  75                  80  
Pro Ser Ala Pro Ala Arg Gly Glu Ala Gly Ala Pro Pro Thr Thr Thr
                85                  90                  95      
Ala Ala Thr Asp Lys Pro Phe Lys Cys Thr Val Cys Arg Val Ser Tyr
            100                 105                 110         
Asn Gln Ser Ser Thr Leu Glu Ile His Met Arg Ser Val Leu His Gln
        115                 120                 125             
Thr Arg Ser Arg Gly Thr Lys Thr Asp Ser Lys Ile Glu Gly Pro Glu
    130                 135                 140                 
Arg Ser Gln Glu Glu Pro Lys Glu Gly Glu Thr Glu Gly Glu Val Gly
145                 150                 155                 160 
Thr Glu Lys Lys Gly Pro Asp Thr Ser Gly Phe Ile Ser Gly Leu Pro
                165                 170                 175     
Phe Leu Ser Pro Pro Pro Pro Pro Leu Asp Leu His Arg Phe Pro Ala
            180                 185                 190         
Pro Leu Phe Thr Pro Pro Val Leu Pro Pro Phe Pro Leu Val Pro Glu
        195                 200                 205             
Ser Leu Leu Lys Leu Gln Gln Gln Gln Leu Leu Leu Pro Phe Tyr Leu
    210                 215                 220                 
His Asp Leu Lys Val Gly Pro Lys Leu Thr Leu Ala Gly Pro Ala Pro
225                 230                 235                 240 
Val Leu Ser Leu Pro Ala Ala Thr Pro Pro Pro Pro Pro Gln Pro Pro
                245                 250                 255     
Lys Ala Glu Leu Ala Glu Arg Glu Trp Glu Arg Pro Pro Met Ala Lys
            260                 265                 270         
Glu Gly Asn Glu Ala Gly Pro Ser Ser Pro Pro Asp Pro Leu Pro Asn
        275                 280                 285             
Glu Ala Ala Arg Thr Ala Ala Lys Ala Leu Leu Glu Asn Phe Gly Phe
    290                 295                 300                 
Glu Leu Val Ile Gln Tyr Asn Glu Gly Lys Gln Ala Val Pro Pro Pro
305                 310                 315                 320 
Pro Thr Pro Pro Pro Pro Glu Ala Leu Gly Gly Gly Asp Lys Leu Ala
                325                 330                 335     
Cys Gly Ala Cys Gly Lys Leu Phe Ser Asn Met Leu Ile Leu Lys Thr
            340                 345                 350         
His Glu Glu His Val His Arg Arg Phe Leu Pro Phe Glu Ala Leu Ser
        355                 360                 365             
Arg Tyr Ala Ala Gln Phe Arg Lys Ser Tyr Asp Ser Leu Tyr Pro Pro
    370                 375                 380                 
Leu Ala Glu Pro Pro Lys Pro Pro Asp Gly Ser Leu Asp Ser Pro Val
385                 390                 395                 400 
Pro His Leu Gly Pro Pro Phe Leu Val Pro Glu Pro Glu Ala Gly Gly
                405                 410                 415     
Thr Arg Ala Pro Glu Glu Arg Ser Arg Ala Gly Gly His Trp Pro Ile
            420                 425                 430         
Glu Glu Glu Glu Ser Ser Arg Gly Asn Leu Pro Pro Leu Val Pro Ala
        435                 440                 445             
Gly Arg Arg Phe Ser Arg Thr Lys Phe Thr Glu Phe Gln Thr Gln Ala
    450                 455                 460                 
Leu Gln Ser Phe Phe Glu Thr Ser Ala Tyr Pro Lys Asp Gly Glu Val
465                 470                 475                 480 
Glu Arg Leu Ala Ser Leu Leu Gly Leu Ala Ser Arg Val Val Val Val
                485                 490                 495     
Trp Phe Gln Asn Ala Arg Gln Lys Ala Arg Lys Asn Ala Cys Glu Gly
            500                 505                 510         
Gly Ser Met Pro Thr Gly Gly Gly Thr Gly Gly Ala Ser Gly Cys Arg
        515                 520                 525             
Arg Cys His Ala Thr Phe Ser Cys Val Phe Glu Leu Val Arg His Leu
    530                 535                 540                 
Lys Lys Cys Tyr Asp Asp Gln Thr Leu Glu Glu Glu Glu Glu Glu Ala
545                 550                 555                 560 
Glu Arg Gly Glu Glu Glu Glu Glu Val Glu Glu Glu Glu Val Glu Glu
                565                 570                 575     
Glu Gln Gly Leu Glu Pro Pro Ala Gly Pro Glu Gly Pro Leu Pro Glu
            580                 585                 590         
Pro Pro Asp Gly Glu Glu Leu Ser Gln Ala Glu Ala Thr Lys Ala Gly
        595                 600                 605             
Gly Lys Glu Pro Glu Glu Lys Ala Thr Pro Ser Pro Ser Pro Ala His
    610                 615                 620                 
Thr Cys Asp Gln Cys Ala Ile Ser Phe Ser Ser Gln Asp Leu Leu Thr
625                 630                 635                 640 
Ser His Arg Arg Leu His Phe Leu Pro Ser Leu Gln Pro Ser Ala Pro
                645                 650                 655     
Pro Gln Leu Leu Asp Leu Pro Leu Leu Val Phe Gly Glu Arg Asn Pro
            660                 665                 670         
Leu Val Ala Ala Thr Ser Pro Met Pro Gly Pro Pro Leu Lys Arg Lys
        675                 680                 685             
His Glu Asp Gly Ser Leu Ser Pro Thr Gly Ser Glu Ala Gly Gly Gly
    690                 695                 700                 
Gly Glu Gly Glu Pro Pro Arg Asp Lys Arg Leu Arg Thr Thr Ile Leu
705                 710                 715                 720 
Pro Glu Gln Leu Glu Ile Leu Tyr Arg Trp Tyr Met Gln Asp Ser Asn
                725                 730                 735     
Pro Thr Arg Lys Met Leu Asp Cys Ile Ser Glu Glu Val Gly Leu Lys
            740                 745                 750         
Lys Arg Val Val Gln Val Trp Phe Gln Asn Thr Arg Ala Arg Glu Arg
        755                 760                 765             
Lys Gly Gln Phe Arg Ser Thr Pro Gly Gly Val Pro Ser Pro Ala Val
    770                 775                 780                 
Lys Pro Pro Ala Thr Ala Thr Pro Ala Ser Leu Pro Lys Phe Asn Leu
785                 790                 795                 800 
Leu Leu Gly Lys Val Asp Asp Gly Thr Gly Arg Glu Ala Pro Lys Arg
                805                 810                 815     
Glu Ala Pro Ala Phe Pro Tyr Pro Thr Ala Thr Leu Ala Ser Gly Pro
            820                 825                 830         
Gln Pro Phe Leu Pro Pro Gly Lys Glu Ala Thr Thr Pro Thr Pro Glu
        835                 840                 845             
Pro Pro Leu Pro Leu Leu Pro Pro Pro Pro Pro Ser Glu Glu Glu Gly
    850                 855                 860                 
Pro Glu Glu Pro Pro Lys Ala Ser Pro Glu Ser Glu Ala Cys Ser Leu
865                 870                 875                 880 
Ser Ala Gly Asp Leu Ser Asp Ser Ser Ala Ser Ser Leu Ala Glu Pro
                885                 890                 895     
Glu Ser Pro Gly Ala Gly Gly Thr Ser Gly Gly Pro Gly Gly Gly Thr
            900                 905                 910         
Gly Val Pro Asp Gly Met Gly Gln Arg Arg Tyr Arg Thr Gln Met Ser
        915                 920                 925             
Ser Leu Gln Leu Lys Ile Met Lys Ala Cys Tyr Glu Ala Tyr Arg Thr
    930                 935                 940                 
Pro Thr Met Gln Glu Cys Glu Val Leu Gly Glu Glu Ile Gly Leu Pro
945                 950                 955                 960 
Lys Arg Val Ile Gln Val Trp Phe Gln Asn Ala Arg Ala Lys Glu Lys
                965                 970                 975     
Lys Ala Lys Leu Gln Gly Thr Ala Ala Gly Ser Thr Gly Gly Ser Ser
            980                 985                 990         
Glu Gly Leu Leu Ala Ala Gln Arg Thr Asp Cys Pro Tyr Cys Asp Val
        995                 1000                1005            
Lys Tyr Asp Phe Tyr Val Ser Cys Arg Gly His Leu Phe Ser Arg Gln
    1010                1015                1020                
His Leu Ala Lys Leu Lys Glu Ala Val Arg Ala Gln Leu Lys Ser Glu
1025                1030                1035                1040
Ser Lys Cys Tyr Asp Leu Ala Pro Ala Pro Glu Ala Pro Pro Ala Leu
                1045                1050                1055    
Lys Ala Pro Pro Ala Thr Thr Pro Ala Ser Met Pro Leu Gly Ala Ala
            1060                1065                1070        
Pro Thr Leu Pro Arg Leu Ala Pro Val Leu Leu Ser Gly Pro Ala Leu
        1075                1080                1085            
Ala Gln Pro Pro Leu Gly Asn Leu Ala Pro Phe Asn Ser Gly Pro Ala
    1090                1095                1100                
Ala Ser Ser Gly Leu Leu Gly Leu Ala Thr Ser Val Leu Pro Thr Thr
1105                1110                1115                1120
Thr Val Val Gln Thr Ala Gly Pro Gly Arg Pro Leu Pro Gln Arg Pro
                1125                1130                1135    
Met Pro Asp Gln Thr Asn Thr Ser Thr Ala Gly Thr Thr Asp Pro Val
            1140                1145                1150        
Pro Gly Pro Pro Thr Glu Pro Leu Gly Asp Lys Val Ser Ser Glu Arg
        1155                1160                1165            
Lys Pro Val Ala Gly Pro Thr Ser Ser Ser Asn Asp Ala Leu Lys Asn
    1170                1175                1180                
Leu Lys Ala Leu Lys Thr Thr Val Pro Ala Leu Leu Gly Gly Gln Phe
1185                1190                1195                1200
Leu Pro Phe Pro Leu Pro Pro Ala Gly Gly Thr Ala Pro Pro Ala Val
                1205                1210                1215    
Phe Gly Pro Gln Leu Gln Gly Ala Tyr Phe Gln Gln Leu Tyr Gly Met
            1220                1225                1230        
Lys Lys Gly Leu Phe Pro Met Asn Pro Met Ile Pro Gln Thr Leu Ile
        1235                1240                1245            
Gly Leu Leu Pro Asn Ala Leu Leu Gln Pro Pro Pro Gln Pro Pro Glu
    1250                1255                1260                
Pro Thr Ala Thr Ala Pro Pro Lys Pro Pro Glu Leu Pro Ala Pro Gly
1265                1270                1275                1280
Glu Gly Glu Ala Gly Glu Val Asp Glu Leu Leu Thr Gly Ser Thr Gly
                1285                1290                1295    
Ile Ser Thr Val Asp Val Thr His Arg Tyr Leu Cys Arg Gln Cys Lys
            1300                1305                1310        
Met Ala Phe Asp Gly Glu Ala Pro Ala Thr Ala His Gln Arg Ser Phe
        1315                1320                1325            
Cys Phe Phe Gly Arg Gly Ser Gly Gly Ser Met Pro Pro Pro Leu Arg
    1330                1335                1340                
Val Pro Ile Cys Thr Tyr His Cys Leu Ala Cys Glu Val Leu Leu Ser
1345                1350                1355                1360
Gly Arg Glu Ala Leu Ala Ser His Leu Arg Ser Ser Ala His Arg Arg
                1365                1370                1375    
Lys Ala Ala Pro Pro Gln Gly Gly Pro Pro Ile Ser Ile Thr Asn Ala
            1380                1385                1390        
Ala Thr Ala Ala Ser Ala Ala Val Ala Phe Ala Lys Glu Glu Ala Arg
        1395                1400                1405            
Leu Pro His Thr Asp Ser Asn Pro Lys Thr Thr Thr Thr Ser Thr Leu
    1410                1415                1420                
Leu Ala Leu
1425        


<210> 2874
<211> 1096
<212> PRT
<213> Homo sapiens

<400> 2874
Met Glu Ser Val Gln Val Trp Glu Gln Trp Pro Glu Thr Ala Gln Leu
 1               5                  10                  15      
Gln Cys Val Gly Gly Gly Pro Ser Val Arg Ser Pro Pro Val Trp Val
            20                  25                  30          
Glu Ser Gln Pro Asp Arg Leu Asp Ser Ser Thr Leu Asp Thr Gly Leu
        35                  40                  45              
Cys Ile Met Thr Leu Thr Val Pro His Ile Trp Leu Pro Pro Pro Arg
    50                  55                  60                  
Tyr Tyr Leu Met Ser Ser Ser Ala Gly Ser Gln Thr Gly Val Leu Arg
65                  70                  75                  80  
Ser Gly Asp Ala Ala Cys Ser Phe Leu Ala Val Ala Ala Ser Ser Ser
                85                  90                  95      
Ile His Pro His Ala Gln Thr Arg Ala Gln Glu Pro Pro Gly Gln Leu
            100                 105                 110         
Arg Pro Tyr Arg Gln Arg Leu Asn Gln Phe Leu Ala Pro Ala Gly Ala
        115                 120                 125             
Val Leu Leu Ile Met Cys Gly Lys Asp Gly Gln Ser Gln Ala Arg Pro
    130                 135                 140                 
Leu Ser Pro Gly Ala Pro Val Ser Lys Ala Pro Asp Ala Leu Val His
145                 150                 155                 160 
Thr Lys Pro Ser Val Tyr Cys Leu Leu His Ala Arg Glu Gly Ser Lys
                165                 170                 175     
Ser Gly Ser His Leu Val His Gly Thr Ser Val Leu Asp Gln Thr Leu
            180                 185                 190         
His Gln Gly Pro Arg Leu Arg Asn Cys Asp Ser Ala Leu Pro Trp Leu
        195                 200                 205             
Leu Ala Arg Leu Arg Gly Gly Ser Leu His Pro Gly Trp His Leu Leu
    210                 215                 220                 
Leu Asn Arg Glu Arg Ser Arg Glu Ile Gln Gly Phe Ala Glu Thr Ala
225                 230                 235                 240 
Arg Glu Gly Asp Asn Leu Ser Leu Ser Ser Val Thr Leu Ala Trp Ala
                245                 250                 255     
Gln Thr Leu Ser Pro Leu Pro Val Pro Ala His Thr Leu Ala Val Leu
            260                 265                 270         
Ala Gln Ala Leu Pro Glu Lys Ser Pro Ser Pro Leu Leu Trp Ser Pro
        275                 280                 285             
Asp Val Val Arg Val Cys Gly Val Ser Gly Glu Leu Phe Pro Gly Pro
    290                 295                 300                 
Met Asp Leu Glu Ala Ser Val Ala Leu Leu Thr Thr Leu Gln Ser Phe
305                 310                 315                 320 
Cys Trp Ala Ser Pro Cys Ala Thr Gly Pro Arg Pro Arg Leu Gln Gly
                325                 330                 335     
Gln Gln Ser Gln Ala Ala Pro Thr His Pro Lys Ala Leu Leu Met Gln
            340                 345                 350         
Leu Pro Pro Ala Arg Ile Pro Leu Gly Gly Thr Met Ser Cys Gly Cys
        355                 360                 365             
Gly Arg Gly Ala Ala Phe Pro Gln Ala Leu Trp Ala Trp Arg Glu Thr
    370                 375                 380                 
Leu Gly Arg Lys Gly Pro Leu Phe Pro Val Leu Glu Pro Gly His Leu
385                 390                 395                 400 
Arg Ser Glu Leu Thr Arg Arg Pro Pro Gly Gly Ala Arg Glu Glu Leu
                405                 410                 415     
Pro Gly Pro Val Thr Pro Pro Asp Phe Cys Ser Gln Thr Pro Glu Ala
            420                 425                 430         
Arg Gly Ala Lys Pro Gly Ser Phe Tyr Ser Leu Met Met Ser Arg Ser
        435                 440                 445             
Arg Ala Gly Lys His Glu Arg Asp Glu Leu Cys Val Trp Glu Pro Leu
    450                 455                 460                 
Thr Ser Val Tyr Pro Asp Ala Asp Ser Gly Pro Ile Asn Thr Asp Arg
465                 470                 475                 480 
Gly Pro Ala Lys Ser Thr Thr Pro His His Ala Leu Val Asn Arg Arg
                485                 490                 495     
Gln Val Thr Arg Glu Met Arg Val Ser Ser Gln Gly Cys Ala Cys Ile
            500                 505                 510         
Phe Thr Val Cys Cys Met Pro Gly Ser Ser Leu Gly Ile Arg Cys Arg
        515                 520                 525             
Gln Asp Phe Gly Leu Cys Leu Leu Leu His Pro Ala Leu Ser Pro Pro
    530                 535                 540                 
Thr Val Glu Asp Pro Val Ser Pro Ala Pro Ser Pro Phe His Val Ser
545                 550                 555                 560 
Pro Gln Ala Leu Val His Val Phe Thr Glu Ala Lys Glu Arg Glu Lys
                565                 570                 575     
Pro Pro Trp Lys Glu Arg Ala Val Pro Gly Gln Gln Arg Gly Gly Glu
            580                 585                 590         
Glu Lys Ala Ile Trp Asp Gly Cys Gly Leu Leu Lys Ala Glu Gln Pro
        595                 600                 605             
Gln Lys Ser Arg Ser Thr Val Cys Ala Ser Arg Asp Thr Ala Leu Gly
    610                 615                 620                 
His His His Val Asp Ile Phe Leu Ile Leu Trp Ala Val Arg Leu Asp
625                 630                 635                 640 
Ser Pro Thr Gln Cys Thr Pro Phe Leu Glu Gly Val Gly His Leu His
                645                 650                 655     
Thr Leu Leu Ser Leu Glu Asp Gly Met Arg Phe Gln Arg Ala Glu Thr
            660                 665                 670         
Glu Arg Arg His Gly Glu Pro Gln Gly Glu Pro Ser Ile Cys Gln Leu
        675                 680                 685             
Gly Phe Lys Gly Phe Tyr Asp Ala Asp Leu Gly Asp Arg Ala Gln Arg
    690                 695                 700                 
Glu Arg Ser Leu Glu Gly Lys Arg Gly Arg Arg Ala Pro Pro Gly Trp
705                 710                 715                 720 
His Gly Gly Cys Ser Cys Ser Arg Asn Gly Gly Cys Arg Asp Leu Ala
                725                 730                 735     
Asp Thr Cys Leu Val Val Gly Pro Asp Gln Pro Arg Glu Gln Phe His
            740                 745                 750         
Ser Val Arg Ala Gln His Thr Pro Ala Pro Gly Phe Trp Gly Ala Lys
        755                 760                 765             
Trp Val Leu Leu Ile Gln Gly Cys Thr Ala Ala Ala Pro Ala Leu Pro
    770                 775                 780                 
Glu Arg Pro Pro Leu Ala Leu Leu Gly Leu Thr Pro Arg Leu Gly Leu
785                 790                 795                 800 
Thr Phe Ser Val Glu Arg Glu Asp Val Thr Ser Ala Ser Asn Arg Thr
                805                 810                 815     
Leu His Thr Cys Ala Glu Arg Gln Lys Asp Val His Leu Lys Ser Asp
            820                 825                 830         
Ser Met Cys Pro His Thr Leu Ala His Ala Tyr Thr Gln Arg Met Pro
        835                 840                 845             
Ser His Thr Ala Pro Cys Gly Ser Gln Ala Pro Asp Asn Leu Gly Arg
    850                 855                 860                 
Gln Ile Ser Ile Ala Asp Arg Ser Val Ser Gln Asn Ser Ser Thr Gly
865                 870                 875                 880 
Gly Pro Arg Arg Thr Glu Leu Gln Asn Arg Arg Val Cys Ala Asn Arg
                885                 890                 895     
Gly Val Cys Ala Asn Arg Gly Val Cys Glu Asn Arg Gly Val Cys Ala
            900                 905                 910         
Ala Cys Pro Arg His Pro Lys Ala Phe Pro Leu His Phe Val Leu Trp
        915                 920                 925             
Ile Gln Ser Ser Leu Trp Lys Asp Asp Gly Lys Ile Cys Leu Leu Gly
    930                 935                 940                 
Pro Gln Ile Ser Arg Ser Lys Phe Gln Leu Pro Arg Gly His Asn Thr
945                 950                 955                 960 
Gly Phe Ser Glu Pro Pro His Pro Asn Phe Ile Ser Pro His Cys Pro
                965                 970                 975     
His Pro Thr Asn Pro Arg Glu Leu His Met Val Asn Gly Met Ser Gly
            980                 985                 990         
Thr Leu Pro Pro Lys Gln His Pro Pro Asp Val Ser Ala Pro Ala Leu
        995                 1000                1005            
Trp Thr Leu Val Ala Ala Thr Cys Asp Gln Gly Gly Gln Gly Gly Leu
    1010                1015                1020                
Pro Gly Pro Pro Trp Ser Thr Arg Arg Arg Pro Leu Pro Ser Pro Arg
1025                1030                1035                1040
Pro Glu Lys Val Ala Asp Gly Ala Ser Leu Lys Asp Val Leu Glu His
                1045                1050                1055    
Glu Pro Ala Leu Thr Gly Asp Gly Gly Gly Arg Ser Gly Pro Ile Ala
            1060                1065                1070        
Phe Thr Leu Val Ala Thr Val Thr Leu His Glu Ala Leu Leu Gly Gln
        1075                1080                1085            
Gln Thr Glu Trp Lys Ile Leu Phe
    1090                1095    


<210> 2875
<211> 1079
<212> PRT
<213> Homo sapiens

<400> 2875
Met Ala Thr Leu Val Gln Ser Leu Gly Gly Gly Phe Gly Pro Ser Thr
 1               5                  10                  15      
Ala Gly Leu Ser Thr Ser Gly Ser Ser Gln Ser Pro Ile Gly Lys Gly
            20                  25                  30          
Thr Tyr Lys Val Leu Ile Ile Asp Pro Thr Gln Asp Thr Thr Thr Pro
        35                  40                  45              
Gln Arg Met His Ala Ser Ile Gly Thr Gln Met Cys Ser Pro Gln Leu
    50                  55                  60                  
Ser Ala Gly Asp Gln Gly Ile Arg Lys Gly Leu Ser Phe Arg Leu Pro
65                  70                  75                  80  
Gly Ala Lys His Leu Ala Glu Gly His Phe Pro Gly Ala Ser Gly Pro
                85                  90                  95      
Asp Ala Ile Leu Pro Pro Gly Pro Cys His Pro Gly Gly Asp Pro Met
            100                 105                 110         
Thr Gln Asn Gln Ala Ala Gln Gln Ile Ala Ser Thr Gly Ser Leu Thr
        115                 120                 125             
Val Gly Leu Pro Pro Gln Asp Ala Thr Leu Pro Ala Thr Pro Leu Gln
    130                 135                 140                 
Val Glu Glu Pro Leu Gln Glu Pro Leu Gly Ala Pro Glu Pro Leu Cys
145                 150                 155                 160 
Pro Pro His Val Ala Cys His Pro Lys Gly Leu Thr Arg Ala Leu Ser
                165                 170                 175     
Leu Ser Gly Ala Leu Pro Cys Met Arg Ala Ser Val Glu Gly Ile Phe
            180                 185                 190         
Leu Gly Tyr Asp Phe Gln Gly Ser His Ser Ser Gly Glu Pro Ile Pro
        195                 200                 205             
Gly Gly His Ser Gly Gln Leu Leu Arg Lys Leu Leu Trp Leu Lys Ala
    210                 215                 220                 
Asp Ala Cys Asp Pro Thr Gln Pro Ala His Gly His Tyr Pro Ser Arg
225                 230                 235                 240 
Ile His Ser Pro Met Leu Val Thr Ala Arg Glu Ala Ala Gly Gln Lys
                245                 250                 255     
Ser Ser Leu Lys Asp Thr Gly Glu Ile Gly Gly Ser Glu Arg Arg Cys
            260                 265                 270         
Gln Asn Ala Pro Pro Pro Gly Gln Pro Pro Pro Arg Thr Gly Ile Thr
        275                 280                 285             
Gly Thr Gln Met Gly Ser Pro Gln Leu Ser Ala Gly Asp Gln Cys Arg
    290                 295                 300                 
Arg Ala Trp Val Arg Cys Pro Gly Cys Ala Ile Gln Gln Ala Pro Gly
305                 310                 315                 320 
Ala Pro Pro Leu Leu Thr Leu Ala Pro Leu His Asp Ser Gly Pro Gln
                325                 330                 335     
Arg Lys Pro Trp Ala Gly Ser Lys Val Thr Asn Gln Leu Thr Ala Asn
            340                 345                 350         
Gln Gly Cys Trp Pro Gly Cys Gln His Cys Cys Gln Ser Gly Ser Pro
        355                 360                 365             
Thr Thr Cys Pro Cys Leu Glu Arg Met Pro Ala Gln Asp Pro Ser Pro
    370                 375                 380                 
Ser Thr His Gln Lys Ser Gln Pro Gly Pro Arg Ala Arg Cys Phe Val
385                 390                 395                 400 
Cys Pro Thr Pro Trp Pro Asn Arg Pro Pro Ile Ser Arg Asp Gly Glu
                405                 410                 415     
Pro Leu Ser Asp Pro Cys Gly Thr Arg Glu Pro Leu Leu Ser His Ser
            420                 425                 430         
Phe Val Leu Gly Ser Pro Gln Gly Gln Thr Leu Thr Pro Ser Val Ser
        435                 440                 445             
Trp Glu Leu Pro Cys Met Arg Leu Lys Glu Pro Phe Pro Asp Trp Thr
    450                 455                 460                 
Thr Val Thr Pro Ala Gly Leu Gln Gly Arg His Arg Leu Gly Ser Asp
465                 470                 475                 480 
Phe Pro Gly Ser Cys Pro Pro Arg Gly Gln Thr His Leu Ser Thr Gly
                485                 490                 495     
Gln Tyr Lys Val Leu Ile Ile Asn Pro Thr Gln Gly Ile Thr Leu His
            500                 505                 510         
Cys Pro Thr Thr His Ala Ser Ser Gly Thr Gln Met Gly Ser Pro Gln
        515                 520                 525             
Leu Ser Ala Ala Asp Gln Gly Ala Arg Lys Gly Leu Ser Phe Ser Ser
    530                 535                 540                 
Pro Gly Ala Glu Pro Arg Ala Ser Gly Pro Asn Ala Ser Leu Pro Leu
545                 550                 555                 560 
Gly Ser Pro Ser Gly Gly Gly Gly Gly Ala Ser Arg Gln Gln Ala Ala
                565                 570                 575     
Ala Leu Tyr Trp Val Glu Gly Thr Leu Cys Cys Leu Gly Leu His Tyr
            580                 585                 590         
Pro Cys Arg Val Ser Gly Lys Ala Ser Phe Leu Gly Ser Ile Asn Lys
        595                 600                 605             
Glu Ala Ala Leu Pro Glu Lys Pro Ser Ile Ser Gly Gly Asp Ser Gly
    610                 615                 620                 
Gln Tyr Lys Val Leu Ile Ile Asp Pro Thr Gln Gly Thr Pro Ser Ile
625                 630                 635                 640 
Pro Thr His Ala Ser Ile Gly Thr Arg Met Cys Ser Pro Gln Leu Arg
                645                 650                 655     
Ala Gly Asp Gln Gly Ala Arg Lys Ser Leu Ser Phe Thr Thr Pro Arg
            660                 665                 670         
Ala Gly His Gln Thr Asp Asp His Ser Pro Arg Asp Ser Gly Pro Asn
        675                 680                 685             
Glu Ser Phe Leu Pro Val Ser Pro Ser Gly Gly Gln Glu Leu Pro His
    690                 695                 700                 
Met Thr Pro Gly Leu Tyr Trp Pro Leu Gly Val Ser Gln Gly His Leu
705                 710                 715                 720 
Pro Ser His Gly Gln Pro Arg Arg Leu Thr Trp Met Pro Arg Thr Ala
                725                 730                 735     
Ala Asn Leu Ala Val Ala Gln Pro Ala Pro Val Cys Gly Gly Gln Ala
            740                 745                 750         
Pro Arg Pro Cys Ser Thr Pro His Arg Lys Ser Gln Pro Gly Asp Pro
        755                 760                 765             
Gly Pro Arg Asp Pro Ile Ala Arg Lys Gln Pro Gly Gln Val Leu Pro
    770                 775                 780                 
Gln Gln Ala Phe Ser Pro Gln Glu Asp Thr Leu Ser Ala Thr Cys Pro
785                 790                 795                 800 
Gln Gly Ser His Arg Thr Met Glu Gly Gln Gly Arg Gln Val Pro Gly
                805                 810                 815     
Leu Arg Gln Asp Thr Arg Ala Val Leu Leu Gln Ala Ser Leu Ala His
            820                 825                 830         
Ala Gly Ser Leu Met Thr Gln Ala Ala Leu Gly Pro Leu Gly Arg Arg
        835                 840                 845             
Gln Gly His Gln Pro Ala His Ser Glu Pro Arg Thr Leu Ala Arg Met
    850                 855                 860                 
Pro Arg Thr Thr Ala Asn Leu Ala Ala Ala Gln Pro Ala Leu Cys Met
865                 870                 875                 880 
Glu Glu Gln Tyr Lys Val Leu Ile Ile Asp Pro Thr Gln Cys Ile Pro
                885                 890                 895     
Leu Pro Ala His Val Ser Arg Gly Thr Gln Met Cys Ser Pro Gln Leu
            900                 905                 910         
Ser Ala Gly Asp Gln Asp Ala Arg Lys Gly Leu Ser Phe Ser Ser Pro
        915                 920                 925             
Gly Val Glu His Met Ala Glu Arg His Trp Pro Gly Ala Ser Gly Pro
    930                 935                 940                 
Asn Ala Arg Leu Pro Leu Gly Ser Pro Ser Gly Gly Asp Ala Ile Leu
945                 950                 955                 960 
Leu Ala Thr Pro Leu Trp Gly Gly Val Thr Phe Ser Gly Thr Gln Thr
                965                 970                 975     
Ala Pro Leu Ala Gln Ser Pro Asn Ser Gln Gly Gln Pro Ala Ala Pro
            980                 985                 990         
Pro Gly Leu Ser Ser Asp Ser Glu Ile Glu His Gly Ser Glu Ser Ser
        995                 1000                1005            
Ala Tyr His Thr Pro Gln Arg Ala Val Ser Ser Ala Val Pro Ala Ala
    1010                1015                1020                
Ala Lys Pro Leu Phe Asn Gly Val Gly Pro Ser Pro Leu Arg Leu Ile
1025                1030                1035                1040
Cys Val Ser Arg Met Gln Pro Gly Met Pro Leu Gln Lys Pro Ala Lys
                1045                1050                1055    
Asp Gly Phe Phe Trp Gly Asn Arg Lys Ser Leu Lys Leu Gln Lys Val
            1060                1065                1070        
Gly Lys Asn Lys Glu Glu Ala
        1075                


<210> 2876
<211> 163
<212> PRT
<213> Homo sapiens

<400> 2876
Met Pro Met Ser Cys Lys Trp Leu Ser Asn Cys Leu Ser Pro Val Ala
 1               5                  10                  15      
Leu Ser Leu Trp Glu Ala Ser Thr Ala Cys Gln Trp Tyr Val Asn Ala
            20                  25                  30          
Ile Ala Ser Val Ala Val Phe Ser His Lys Thr Val Asn Thr Val Lys
        35                  40                  45              
Gln Ile Pro Leu Trp Cys Leu Thr Thr Gly Val Gln Cys Lys Ala Asp
    50                  55                  60                  
Gly Arg Ala Ala Pro Gly Asn Ser Gly Asp Arg His Gln Ala Trp Asp
65                  70                  75                  80  
Gly Met Asp Lys Gly Arg Leu Gln Glu Glu Glu His Gly Gly Asp Ala
                85                  90                  95      
Gly Asp His Phe Ala Asp Ile Gly Gly Ile His Gly Ser Glu Asn Ser
            100                 105                 110         
Lys Gln Ser Ala Tyr Gly His Val Val Ser Lys His Leu Lys Leu Ile
        115                 120                 125             
Ala Ala Tyr Glu Glu Val Gln Ile Ser Gly Ile Cys Ser Cys Pro Arg
    130                 135                 140                 
Gln Gly Thr Gln Arg Glu Arg Ala Val Trp Gln Ala Lys Gly Met Leu
145                 150                 155                 160 
Lys Arg Gln
            


<210> 2877
<211> 690
<212> PRT
<213> Homo sapiens

<400> 2877
Met Ala Glu Asn Asn Leu Lys Met Leu Lys Ile Gln Gln Cys Val Val
 1               5                  10                  15      
Ala Asn Lys Leu Pro Arg Asn Arg Pro Tyr Val Cys Asn Ile Cys Phe
            20                  25                  30          
Lys His Phe Glu Thr Pro Ser Lys Leu Ala Arg His Tyr Leu Ile His
        35                  40                  45              
Thr Gly Gln Lys Pro Phe Glu Cys Asp Val Cys His Lys Thr Phe Arg
    50                  55                  60                  
Gln Leu Val His Leu Glu Arg His Gln Leu Thr His Ser Leu Pro Phe
65                  70                  75                  80  
Lys Cys Ser Ile Cys Gln Arg His Phe Lys Asn Leu Lys Thr Phe Val
                85                  90                  95      
Lys His Gln Gln Leu His Asn Glu Thr Tyr Gln Asn Asn Val Lys Gln
            100                 105                 110         
Val Arg Arg Leu Leu Glu Ala Lys Gln Glu Lys Ser Met Tyr Gly Val
        115                 120                 125             
Tyr Asn Thr Phe Thr Thr Glu Glu Arg Trp Ala Leu His Pro Cys Ser
    130                 135                 140                 
Lys Ser Asp Pro Met Tyr Ser Met Lys Arg Arg Lys Asn Ile His Ala
145                 150                 155                 160 
Cys Thr Ile Cys Gly Lys Met Phe Pro Ser Gln Ser Lys Leu Asp Arg
                165                 170                 175     
His Val Leu Ile His Thr Gly Gln Arg Pro Phe Lys Cys Val Leu Cys
            180                 185                 190         
Thr Lys Ser Phe Arg Gln Ser Thr His Leu Lys Ile His Gln Leu Thr
        195                 200                 205             
His Ser Glu Glu Arg Pro Phe Gln Cys Cys Phe Cys Gln Lys Gly Phe
    210                 215                 220                 
Lys Ile Gln Ser Lys Leu Leu Lys His Lys Gln Ile His Thr Arg Asn
225                 230                 235                 240 
Lys Ala Phe Arg Ala Leu Leu Leu Lys Lys Arg Arg Thr Glu Ser Arg
                245                 250                 255     
Pro Leu Pro Asn Lys Leu Asn Ala Asn Gln Gly Gly Phe Glu Asn Gly
            260                 265                 270         
Glu Ile Gly Glu Ser Glu Glu Asn Asn Pro Leu Asp Val His Ser Ile
        275                 280                 285             
Tyr Ile Val Pro Phe Gln Cys Pro Lys Cys Glu Lys Cys Phe Glu Ser
    290                 295                 300                 
Glu Gln Ile Leu Asn Glu His Ser Cys Phe Ala Ala Arg Ser Gly Lys
305                 310                 315                 320 
Ile Pro Ser Arg Phe Lys Arg Ser Tyr Asn Tyr Lys Thr Ile Val Lys
                325                 330                 335     
Lys Ile Leu Ala Lys Leu Lys Arg Ala Arg Ser Lys Lys Leu Asp Asn
            340                 345                 350         
Phe Gln Ser Glu Lys Lys Val Phe Lys Lys Ser Phe Leu Arg Asn Cys
        355                 360                 365             
Asp Leu Ile Ser Gly Glu Gln Ser Ser Glu Gln Thr Gln Arg Thr Phe
    370                 375                 380                 
Val Gly Ser Leu Gly Lys His Gly Thr Tyr Lys Thr Ile Gly Asn Arg
385                 390                 395                 400 
Lys Lys Lys Thr Leu Thr Leu Pro Phe Ser Trp Gln Asn Met Gly Lys
                405                 410                 415     
Asn Leu Lys Gly Ile Leu Thr Thr Glu Asn Ile Leu Ser Ile Asp Asn
            420                 425                 430         
Ser Val Asn Lys Lys Asp Leu Ser Ile Cys Gly Ser Ser Gly Glu Glu
        435                 440                 445             
Phe Phe Asn Asn Cys Glu Val Leu Gln Cys Gly Phe Ser Val Pro Arg
    450                 455                 460                 
Glu Asn Ile Arg Thr Arg His Lys Ile Cys Pro Cys Asp Lys Cys Glu
465                 470                 475                 480 
Lys Val Phe Pro Ser Ile Ser Lys Leu Lys Arg His Tyr Leu Ile His
                485                 490                 495     
Thr Gly Gln Arg Pro Phe Gly Cys Asn Ile Cys Gly Lys Ser Phe Arg
            500                 505                 510         
Gln Ser Ala His Leu Lys Arg His Glu Gln Thr His Asn Glu Lys Ser
        515                 520                 525             
Pro Tyr Ala Ser Leu Cys Gln Val Glu Phe Gly Asn Phe Asn Asn Leu
    530                 535                 540                 
Ser Asn His Ser Gly Asn Asn Val Asn Tyr Asn Ala Ser Gln Gln Cys
545                 550                 555                 560 
Gln Ala Pro Gly Val Gln Lys Tyr Glu Val Ser Glu Ser Asp Gln Met
                565                 570                 575     
Ser Gly Val Lys Ala Glu Ser Gln Asp Phe Ile Pro Gly Ser Thr Gly
            580                 585                 590         
Gln Pro Cys Leu Pro Asn Val Leu Leu Glu Ser Glu Gln Ser Asn Pro
        595                 600                 605             
Phe Cys Ser Tyr Ser Glu His Gln Glu Lys Asn Asp Val Phe Leu Tyr
    610                 615                 620                 
Arg Cys Ser Val Cys Ala Lys Ser Phe Arg Ser Pro Ser Lys Leu Glu
625                 630                 635                 640 
Arg His Tyr Leu Ile His Ala Gly Gln Lys Pro Phe Glu Cys Ser Val
                645                 650                 655     
Cys Gly Lys Thr Phe Arg Gln Ala Pro His Trp Lys Arg His Gln Leu
            660                 665                 670         
Thr His Phe Lys Glu Arg Pro Gln Gly Lys Val Val Ala Leu Asp Ser
        675                 680                 685             
Val Met
    690 


<210> 2878
<211> 390
<212> PRT
<213> Homo sapiens

<400> 2878
Met Ile Ile Gln Ser Leu Leu Ser Pro Leu Asn Leu Glu Val Asp Pro
 1               5                  10                  15      
Asn Ile Gln Ala Met His Thr Gln Glu Lys Glu His Ile Lys Ser Leu
            20                  25                  30          
Asn Asn Lys Phe Ala Ser Phe Ile Asp Lys Val Gln Phe Leu Glu Gln
        35                  40                  45              
Gln Asn Lys Met Leu Glu Thr Lys Trp Ser Leu Val Gln Gln Gln Lys
    50                  55                  60                  
Lys Ala Arg Ser Asn Val Asp His Gln Phe Glu Ser Tyr Ile Asn Asn
65                  70                  75                  80  
Leu Trp Gln Gln Leu Glu Thr Leu Gly Gln Asp Lys Leu Lys Leu Glu
                85                  90                  95      
Ala Gly Leu Gly Asn Met Gln Gly Leu Asp Asp Glu Ile Asn Glu Arg
            100                 105                 110         
Ala Glu Met Glu Asn Glu Phe Val Leu Leu Lys Lys Asp Val Asp Glu
        115                 120                 125             
Ala Tyr Ile Asn Lys Val Gln Leu Glu Ser Gly Leu Glu Ala Leu Thr
    130                 135                 140                 
Asp Glu Ile Asn Phe Leu Arg Gln Leu Tyr Glu Glu Glu Ile Gln Glu
145                 150                 155                 160 
Leu Pro Ser Gln Ile Ser His Thr Pro Val Val Leu Ser Met Asp Asn
                165                 170                 175     
Ser Arg Cys Leu Asp Thr Asp Ser Ile Ile Thr Glu Val Lys Ala Gln
            180                 185                 190         
Tyr Glu Glu Ile Ala Asn Arg Ser Arg Ala Glu Ala Glu Ser Met His
        195                 200                 205             
Gln Ser Lys His Glu Glu Leu Gln Thr Leu Ala Gly Lys His Gly Asp
    210                 215                 220                 
Asp Leu Gln Cys Thr Lys Thr Glu Ile Ser Glu Met Asn Trp Asn Ile
225                 230                 235                 240 
Ser Arg Leu Gln Ala Glu Ile Glu Gly Leu Lys Asp Arg Arg Ala Ser
                245                 250                 255     
Leu Glu Ala Ala Met Val Asp Ala Glu Gln Arg Gly Glu Leu Ala Val
            260                 265                 270         
Lys Asp Ala Asn Ala Lys Leu Ser Glu Leu Glu Ala Ala Leu Arg Gln
        275                 280                 285             
Ala Lys Gln Asp Met Val Arg Gln Leu Pro Glu Tyr Gln Glu Leu Met
    290                 295                 300                 
Asn Ala Gly Pro Gly His Gly Asn Pro Thr Tyr Arg Lys Leu Leu Glu
305                 310                 315                 320 
Gly Glu Glu Ser Arg Leu Ala Ser Gly Met Gln Asn Met Ser Ile Gln
                325                 330                 335     
Thr Lys Thr Thr Ser Gly Tyr Ala Asp Val Leu Ser Ser Gly Tyr Gly
            340                 345                 350         
Gly Leu Thr Ala Cys Ala Pro Ala Leu Ala Leu Ala Gly Gly Ser Ser
        355                 360                 365             
Ser Phe Ser Arg Thr Ser Ser Met Val Val Lys Lys Met Glu Thr Arg
    370                 375                 380                 
Asp Gly Lys Leu Val Ser
385                 390 


<210> 2879
<211> 525
<212> PRT
<213> Homo sapiens

<400> 2879
Met Ala Glu Thr Val Gly Thr Ala Glu Thr Val Gly Met Ala Glu Thr
 1               5                  10                  15      
Val Gly Thr Ala Glu Pro Val Gly Thr Pro Glu Thr Val Gly Thr Ala
            20                  25                  30          
Glu Thr Val Gly Thr Gln Thr Val Gly Thr Ala Glu Thr Val Gly Thr
        35                  40                  45              
Pro Glu Thr Val Gly Met Ala Glu Thr Val Gly Ala Pro Glu Thr Val
    50                  55                  60                  
Gly Thr Ala Glu Thr Val Gly Thr Pro Glu Thr Val Gly Met Ala Glu
65                  70                  75                  80  
Thr Val Gly Ala Pro Glu Thr Val Gly Thr Ala Glu Thr Val Gly Thr
                85                  90                  95      
Ala Glu Thr Val Gly Thr Pro Glu Thr Leu Gly Thr Ala Glu Thr Met
            100                 105                 110         
Gly Thr Ala Glu Thr Val Gly Thr Pro Glu Thr Leu Gly Thr Ala Glu
        115                 120                 125             
Thr Met Gly Met Leu Arg Pro Trp Gly Leu Leu Arg Pro Leu Leu Leu
    130                 135                 140                 
Gly Val Gly Asp Val Lys Phe Pro Gln Cys Leu Ala Ala Pro Ala Gly
145                 150                 155                 160 
Pro Thr Arg Glu Ala Pro Glu Ser His Ala Pro Gln Arg Gln Pro Leu
                165                 170                 175     
Gly Glu Val Leu Gly Ser Phe Ser Ser Pro Ala Gln Gly Ser Leu Ser
            180                 185                 190         
Pro Leu Tyr Ser Ser Gly Val His Phe Ala Ser Phe Arg Asn Ala Ser
        195                 200                 205             
Leu Met Ser Leu Gly Ser Ala Ser Gly Pro Gly Arg Arg Arg Phe Pro
    210                 215                 220                 
Gln Ala Leu Ile Val Gly Val Lys Lys Gly Gly Thr Arg Ala Leu Leu
225                 230                 235                 240 
Glu Phe Leu Arg Leu His Pro Asp Val Arg Ala Leu Gly Ser Glu Pro
                245                 250                 255     
His Phe Phe Asp Arg Cys Tyr Glu Arg Gly Leu Ala Trp Tyr Arg Met
            260                 265                 270         
Asp Val Gly Val Arg Gln Pro Gln Leu Lys Gln Pro Ala Leu Val Ala
        275                 280                 285             
Ala His Pro Gln Ala Trp Thr Gln Arg Leu Gln Arg Gly Pro Cys Pro
    290                 295                 300                 
Arg Pro Val Gly Glu Ser Val Gly Val Ala Gly Pro Arg Arg Phe Ser
305                 310                 315                 320 
Arg Ser Leu Met Pro Arg Thr Leu Asp Gly Gln Ile Thr Met Glu Lys
                325                 330                 335     
Thr Pro Ser Tyr Phe Val Thr Arg Glu Ala Pro Arg Arg Ile His Ala
            340                 345                 350         
Met Ser Pro Asp Thr Lys Leu Ile Val Val Val Arg Asn Pro Val Thr
        355                 360                 365             
Arg Ala Ile Ser Asp Tyr Ala Gln Thr Leu Ser Lys Thr Pro Gly Leu
    370                 375                 380                 
Pro Ser Phe Arg Ala Leu Ala Phe Arg His Gly Leu Gly Pro Val Asp
385                 390                 395                 400 
Thr Ala Trp Ser Ala Val Arg Ile Gly Leu Tyr Ala Gln His Leu Asp
                405                 410                 415     
His Trp Leu Arg Tyr Phe Pro Leu Ser His Phe Leu Phe Val Ser Gly
            420                 425                 430         
Glu Arg Leu Val Ser Asp Pro Ala Gly Glu Val Gly Arg Val Gln Asp
        435                 440                 445             
Phe Leu Gly Leu Lys Arg Val Val Thr Asp Lys His Phe Tyr Phe Asn
    450                 455                 460                 
Ala Thr Lys Gly Phe Pro Cys Leu Lys Lys Ala Gln Gly Gly Ser Arg
465                 470                 475                 480 
Pro Arg Cys Leu Gly Lys Ser Lys Gly Arg Pro His Pro Arg Val Pro
                485                 490                 495     
Gln Ala Leu Val Arg Arg Leu Gln Glu Phe Tyr Arg Pro Phe Asn Arg
            500                 505                 510         
Arg Phe Tyr Gln Met Thr Gly Gln Asp Phe Gly Trp Gly
        515                 520                 525 


<210> 2880
<211> 855
<212> PRT
<213> Homo sapiens

<400> 2880
Met Lys Tyr Phe Leu Arg Pro Thr Val Cys Ile Gln Val Cys Pro Phe
 1               5                  10                  15      
Ser Leu Arg Val Val Ser Val Val Gly Ile Thr Tyr Leu Leu Pro Gln
            20                  25                  30          
Glu Glu Gln Pro Leu Cys His Pro Ile Val Glu Arg Ala Leu Lys Ser
        35                  40                  45              
Cys Gly Pro Gly Gly Thr Ala His Val Lys Leu Val Val Glu Trp Asp
    50                  55                  60                  
Lys Glu Thr Arg Asp Phe Leu Phe Val Asn Thr Glu Asp Glu Tyr Ile
65                  70                  75                  80  
Pro Asp Ala Glu Ser Val Arg Leu Gln Arg Glu Arg His His Gln Pro
                85                  90                  95      
Gln Thr Cys Thr Leu Ser Gln Cys Phe Gln Leu Tyr Thr Lys Glu Glu
            100                 105                 110         
Arg Leu Ala Pro Asp Asp Ala Trp Arg Cys Pro His Cys Lys Gln Leu
        115                 120                 125             
Gln Gln Gly Ser Ile Thr Leu Ser Leu Trp Thr Leu Pro Asp Val Leu
    130                 135                 140                 
Ile Ile His Leu Lys Arg Phe Arg Gln Glu Gly Asp Arg Arg Met Lys
145                 150                 155                 160 
Leu Gln Asn Met Val Lys Phe Pro Leu Thr Gly Leu Asp Met Thr Pro
                165                 170                 175     
His Val Val Lys Arg Ser Gln Ser Ser Trp Ser Leu Pro Ser His Trp
            180                 185                 190         
Ser Pro Trp Arg Arg Pro Tyr Gly Leu Gly Arg Asp Pro Glu Asp Tyr
        195                 200                 205             
Ile Tyr Asp Leu Tyr Ala Val Cys Asn His His Gly Thr Met Gln Gly
    210                 215                 220                 
Gly His Tyr Thr Ala Tyr Cys Lys Asn Ser Val Asp Gly Leu Trp Tyr
225                 230                 235                 240 
Cys Phe Asp Asp Ser Asp Val Gln Gln Leu Ser Glu Asp Glu Val Cys
                245                 250                 255     
Thr Gln Thr Ala Tyr Ile Leu Phe Tyr Gln Arg Arg Thr Ala Ile Pro
            260                 265                 270         
Ser Trp Ser Ala Asn Ser Ser Val Ala Gly Ser Thr Ser Ser Ser Leu
        275                 280                 285             
Cys Glu His Trp Val Ser Arg Leu Pro Gly Ser Lys Pro Ala Ser Val
    290                 295                 300                 
Thr Ser Ala Ala Ser Ser Arg Arg Thr Ser Leu Ala Ser Leu Ser Glu
305                 310                 315                 320 
Ser Val Glu Met Thr Gly Glu Arg Ser Glu Asp Asp Gly Gly Phe Ser
                325                 330                 335     
Thr Arg Pro Phe Val Arg Ser Val Gln Arg Gln Ser Leu Ser Ser Arg
            340                 345                 350         
Ser Ser Val Thr Ser Pro Leu Ala Val Asn Glu Asn Cys Met Arg Pro
        355                 360                 365             
Ser Trp Ser Leu Ser Ala Lys Leu Gln Met Arg Ser Asn Ser Pro Ser
    370                 375                 380                 
Arg Phe Ser Gly Asp Ser Pro Ile His Ser Ser Ala Ser Thr Leu Glu
385                 390                 395                 400 
Lys Ile Gly Glu Ala Ala Asp Asp Lys Val Ser Ile Ser Cys Phe Gly
                405                 410                 415     
Ser Leu Arg Asn Leu Ser Ser Ser Tyr Gln Glu Pro Ser Asp Ser His
            420                 425                 430         
Ser Leu Arg Glu His Lys Ala Val Gly Arg Ala Pro Leu Ala Val Met
        435                 440                 445             
Glu Gly Val Phe Lys Asp Glu Ser Asp Thr Arg Arg Leu Asn Ser Ser
    450                 455                 460                 
Val Val Asp Thr Gln Ser Lys His Ser Ala Gln Gly Asp Arg Leu Pro
465                 470                 475                 480 
Pro Leu Ser Gly Pro Phe Asp Asn Asn Asn Gln Ile Ala Tyr Val Asp
                485                 490                 495     
Gln Ser Asp Ser Val Asp Ser Ser Pro Val Lys Glu Val Lys Ala Pro
            500                 505                 510         
Ser His Pro Gly Ser Leu Ala Lys Lys Pro Glu Ser Thr Thr Lys Arg
        515                 520                 525             
Ser Pro Ser Ser Lys Gly Thr Ser Glu Pro Glu Lys Ser Leu Arg Lys
    530                 535                 540                 
Gly Arg Pro Ala Leu Ala Ser Gln Glu Ser Ser Leu Ser Ser Thr Ser
545                 550                 555                 560 
Pro Ser Ser Pro Leu Pro Val Lys Val Ser Leu Lys Pro Ser Arg Ser
                565                 570                 575     
Arg Ser Lys Ala Asp Ser Ser Ser Arg Gly Ser Gly Arg His Ser Ser
            580                 585                 590         
Pro Ala Pro Ala Gln Pro Lys Lys Glu Ser Ser Pro Lys Ser Gln Asp
        595                 600                 605             
Ser Val Ser Ser Pro Ser Pro Gln Lys Gln Lys Ser Ala Ser Ala Leu
    610                 615                 620                 
Thr Tyr Thr Ala Ser Ser Thr Ser Ala Lys Lys Ala Ser Gly Pro Ala
625                 630                 635                 640 
Thr Arg Ser Pro Phe Pro Pro Gly Lys Ser Arg Thr Ser Asp His Ser
                645                 650                 655     
Leu Ser Arg Glu Gly Ser Arg Gln Ser Leu Gly Ser Asp Arg Ala Ser
            660                 665                 670         
Ala Thr Ser Thr Ser Lys Pro Asn Ser Pro Arg Val Ser Gln Ala Arg
        675                 680                 685             
Ala Gly Glu Gly Arg Gly Ala Gly Lys His Val Arg Ser Ser Ser Met
    690                 695                 700                 
Ala Ser Leu Arg Ser Pro Ser Thr Ser Ile Lys Ser Gly Leu Lys Arg
705                 710                 715                 720 
Asp Ser Lys Ser Glu Asp Lys Gly Leu Ser Phe Phe Lys Ser Ala Leu
                725                 730                 735     
Arg Gln Lys Glu Thr Arg Arg Ser Thr Asp Leu Gly Lys Thr Ala Leu
            740                 745                 750         
Leu Ser Lys Lys Ala Gly Gly Ser Ser Val Lys Ser Val Cys Lys Asn
        755                 760                 765             
Thr Gly Asp Asp Glu Ala Glu Arg Gly His Gln Pro Pro Ala Ser Gln
    770                 775                 780                 
Gln Pro Asn Ala Asn Thr Thr Gly Lys Glu Gln Leu Val Thr Lys Asp
785                 790                 795                 800 
Pro Ala Ser Ala Lys His Ser Leu Leu Ser Ala Arg Lys Ser Lys Ser
                805                 810                 815     
Ser Gln Leu Asp Ser Gly Val Pro Ser Ser Pro Gly Gly Arg Gln Ser
            820                 825                 830         
Ala Glu Lys Ser Ser Lys Lys Leu Ser Ser Ser Met Gln Thr Ser Ala
        835                 840                 845             
Arg Pro Ser Gln Lys Pro Gln
    850                 855 


<210> 2881
<211> 130
<212> PRT
<213> Homo sapiens

<400> 2881
Met Leu Pro Gly Pro Ser Leu Leu Leu Ser Ala Ser His Cys Arg Ala
 1               5                  10                  15      
Pro Pro Val Thr Gly Val Leu Pro Ser Pro Gly Val Thr Glu Val Asn
            20                  25                  30          
Lys Ser Leu Val Ser Arg Asp Pro Leu Pro Val Glu Thr His Pro Ala
        35                  40                  45              
Ser Ser Ser Ser Pro Arg Gly Arg Leu Leu Arg Lys Ala Gly Leu Asp
    50                  55                  60                  
Cys Ser Ser Cys Arg Thr Arg Phe Pro Pro Leu Arg Ser Cys Arg Leu
65                  70                  75                  80  
Ser Gly Ala His Thr Trp Val Cys Ser Gly Phe Ser Arg Gln Leu Phe
                85                  90                  95      
Lys Ala Ala Gly Arg Trp Lys Phe Glu Ala Ser Pro Ala Pro Ala Thr
            100                 105                 110         
Ala Leu Arg Thr Ala Arg Gly His Pro Leu Arg Asn Thr Arg Gly Phe
        115                 120                 125             
Leu Pro
    130 


<210> 2882
<211> 231
<212> PRT
<213> Homo sapiens

<400> 2882
Met Arg Thr Lys Glu Arg Asp Trp Leu Pro Pro Arg Thr Glu His Ser
 1               5                  10                  15      
Pro Ala Ser Arg Phe Lys Asp Lys Gln Phe Thr Glu Gly Arg Gly Ser
            20                  25                  30          
Pro Leu Gly Met Asn Asn Asp Val Phe Thr Met Gly Ser Met Thr Leu
        35                  40                  45              
Arg Ile Leu Asp Lys Arg Gly Arg Thr Gly Thr Glu Glu Leu Asp Arg
    50                  55                  60                  
Cys His Val Val Pro Ala Lys Gly Arg Glu Val Asn Arg His Leu Gln
65                  70                  75                  80  
Asn Pro Asp Thr Ala Gly Lys Lys Asn Phe Thr Arg Val Pro Trp Asn
                85                  90                  95      
His Leu Tyr Asn Asp Gly Phe Lys Leu Leu Lys Pro Gly Leu Leu Ser
            100                 105                 110         
His Leu Lys Ser Gln Gln Met Ala Ala Glu Ala Thr Phe Gly Thr Gly
        115                 120                 125             
Gly His Pro Arg Leu Lys Gly Pro Gln Thr Leu Arg Thr Lys Glu Val
    130                 135                 140                 
Leu Glu Thr Lys Pro Pro Ile His Ala Gly Arg Glu Thr Thr Glu Asn
145                 150                 155                 160 
Asn Gln Tyr Asp Ser Thr Pro Tyr Gly Gly Pro Pro Met Met Pro Met
                165                 170                 175     
Met Gly Pro Pro Pro Pro Pro Gly Val Met Pro Val Glu Pro Ala Pro
            180                 185                 190         
Gly Met Arg Leu Thr Met Gly Gly His Met Pro Met Met Pro Gly Cys
        195                 200                 205             
Pro Met Met Lys Pro Pro Ala Arg Leu Met Met Val Pro Ser Gln Pro
    210                 215                 220                 
Arg Met Thr Arg Pro Asp Arg
225                 230     


<210> 2883
<211> 51
<212> PRT
<213> Homo sapiens

<400> 2883
Met Glu Thr Phe Leu Glu Pro Asn Asn Lys Lys Leu Leu Phe Pro Val
 1               5                  10                  15      
Gly Arg Ser Trp Ser Cys Phe Ala Gln Thr Pro Thr Leu Ala Lys Tyr
            20                  25                  30          
Ile Pro Tyr Ser Leu Trp Lys Tyr Ser Val Leu Ser Gly His Ser Trp
        35                  40                  45              
Pro Leu Gly
    50      


<210> 2884
<211> 232
<212> PRT
<213> Homo sapiens

<400> 2884
Met Ala Arg Leu Leu Arg Ser Ala Thr Trp Glu Leu Phe Pro Trp Arg
 1               5                  10                  15      
Gly Tyr Cys Ser Gln Lys Ala Lys Gly Glu Leu Cys Arg Asp Phe Val
            20                  25                  30          
Glu Ala Leu Lys Ala Val Val Gly Gly Ser His Val Ser Thr Ala Ala
        35                  40                  45              
Val Val Arg Glu Gln His Gly Arg Asp Glu Ser Val His Arg Cys Glu
    50                  55                  60                  
Pro Pro Asp Ala Val Val Trp Pro Gln Asn Val Glu Gln Val Ser Arg
65                  70                  75                  80  
Leu Ala Ala Leu Cys Tyr Arg Gln Gly Val Pro Ile Ile Pro Phe Gly
                85                  90                  95      
Thr Gly Thr Gly Leu Glu Gly Gly Val Cys Ala Val Gln Gly Gly Val
            100                 105                 110         
Cys Val Asn Leu Thr His Met Asp Arg Ile Leu Glu Leu Asn Gln Glu
        115                 120                 125             
Asp Phe Ser Val Val Val Glu Pro Gly Val Thr Arg Lys Ala Leu Asn
    130                 135                 140                 
Ala His Leu Arg Asp Ser Gly Leu Trp Phe Pro Val Asp Pro Gly Ala
145                 150                 155                 160 
Asp Ala Ser Leu Cys Gly Met Ala Ala Thr Gly Ala Ser Gly Thr Asn
                165                 170                 175     
Ala Val Arg Tyr Gly Thr Met Arg Asp Asn Val Leu Asn Leu Glu Val
            180                 185                 190         
Val Leu Pro Asp Gly Arg Leu Leu His Thr Ala Gly Arg Gly Arg His
        195                 200                 205             
Phe Arg Leu Arg Leu Leu Ala Arg Asn Pro Ser Ser His Ser Leu Val
    210                 215                 220                 
Leu Thr Leu Cys Val Pro Gly Thr
225                 230         


<210> 2885
<211> 115
<212> PRT
<213> Homo sapiens

<400> 2885
Met Ala Val Ser Lys Lys Pro Gly Trp Ala Ile Pro Leu Ile Arg Arg
 1               5                  10                  15      
Pro Cys Ser Leu Gln Arg Pro Asp Phe Thr Ala Gln Ser Ser Phe Pro
            20                  25                  30          
Gly Val Gln Ser Asp Val Gly Leu Gly Lys Glu Thr Gly Val Trp Glu
        35                  40                  45              
Glu Gly Ala Ala Gln Glu Ser Glu Gln Ala Phe Ser Asn Thr Gly Ile
    50                  55                  60                  
Asp Ser Pro His Gly Ile Gly Leu Arg Trp Pro Phe Leu Phe Arg Val
65                  70                  75                  80  
Pro Pro Met Asp Arg Ser Ser Pro Val Ser Phe Ser Val Trp Arg Pro
                85                  90                  95      
Asp Ile Glu Gln Gly Leu Phe His Thr Asp Pro Arg Glu Tyr Phe Cys
            100                 105                 110         
Ala Ile Ser
        115 


<210> 2886
<211> 620
<212> PRT
<213> Homo sapiens

<400> 2886
Met Arg Leu Trp Gly Gln Gln Lys Cys Gly Tyr Lys Gly Pro Leu Ala
 1               5                  10                  15      
Leu Cys Gly Ala Arg Ser Arg Arg Gly Ile Asn Thr Leu Thr Leu Thr
            20                  25                  30          
Thr Ala Ser Phe Ile Pro Thr Ile Ser Ser Glu Ile Asn Ile Asp Ile
        35                  40                  45              
Asp Glu Cys Phe Trp Ala Pro Gln Glu Arg Cys Ile Ser Pro Pro Cys
    50                  55                  60                  
Ser Tyr Asp Gln Pro Arg Asp Met Lys Ile Ser Pro Gln Thr Lys Lys
65                  70                  75                  80  
Arg Gly Gln Ala Val His Tyr Thr Ser Thr Pro Leu Phe Thr Tyr Ile
                85                  90                  95      
Ser Met Asp His Ile Thr Ser Glu Lys Thr Ser Gln Ala Glu Thr Val
            100                 105                 110         
Glu Ala Ile Asp Ala Lys Ile Leu Gly Gly Trp Val Gly Val Tyr Ile
        115                 120                 125             
Arg Glu Gly Lys Thr Phe Gln Glu Thr Leu Asn Cys Gly Ile Thr Gly
    130                 135                 140                 
Leu Asn Tyr Asp Asn Gly Leu Pro Pro Ala Thr Arg Lys Met Gly Lys
145                 150                 155                 160 
Leu Asn Ile Phe Ile Gln Ala His Phe Asn Thr Glu Gln Asn Glu Asn
                165                 170                 175     
Ser Val Lys Thr Glu Gly Leu Ala Val Gly Val Gly Phe Gly Ala Ile
            180                 185                 190         
Glu Lys Thr Ala Ser Ala Thr Phe Glu Ser Ala Arg Gly Ala Leu Gly
        195                 200                 205             
Val Arg Val Thr Trp Gly Ser Leu Ser Pro Leu Tyr Pro Val Asp Gln
    210                 215                 220                 
Ala Asn Pro Ala Val Thr Leu Asn Ala Ala Phe Ser Leu Thr Phe His
225                 230                 235                 240 
Thr Glu Ala Leu Gly Leu Val Asn Ser Leu Leu Phe Tyr Leu Pro Gly
                245                 250                 255     
Asn Lys Gln Gly Ile Glu Trp Lys Ser Leu Lys Ser Ser Ser Glu Trp
            260                 265                 270         
Pro Gln Thr Ile Leu Asp Gln Gln Pro Pro Leu Lys Val Arg Arg Lys
        275                 280                 285             
Leu Gln Ser Ser Lys Lys Tyr Thr Asp His Phe Glu Ile Ile Val Gly
    290                 295                 300                 
Ser Leu Trp Ile Gln Glu Arg Gln Thr Glu Asn Ile Leu Leu Asp Lys
305                 310                 315                 320 
Cys Gln Val Asn Leu Arg Phe His Ser Pro Arg Ala Gln Ser His Gln
                325                 330                 335     
Gln His Arg Met Lys Ala Ala Asp Cys Lys Gly Met Asp Gly Ser Ser
            340                 345                 350         
His Leu Ala Ser Leu His Gln Glu Val Ser Glu Asn Cys Thr Lys Arg
        355                 360                 365             
Val Gly Glu Asp Pro Leu Arg Ala Lys Pro Ala Pro Leu Ser Arg Glu
    370                 375                 380                 
Ala Ile Pro Ser Ala Ser Ala Val Pro Ala Gln Phe Leu Asp Ala Thr
385                 390                 395                 400 
Gln Gly Trp Ala Gly Asp Ser Ser Pro Gln Gly Pro Thr Gln His Gln
                405                 410                 415     
Trp Gly Trp Gly Pro Asn Ala Thr Ala Ile Asn Arg Asp Leu Gln Gly
            420                 425                 430         
Arg Ala Glu Ala Ser Ala Phe Ala Gly Ala Pro Cys Asp Trp His Val
        435                 440                 445             
Ser Ser Gly Leu Arg Ala Val Asp Ser Asn Pro Thr Leu Glu Leu Met
    450                 455                 460                 
Gln Val Ile Glu Glu Glu Glu Arg Ala Gly Arg Asp Cys Val Leu His
465                 470                 475                 480 
Trp Ala Thr Pro Thr Ser Gly Pro Leu Thr Asn Ala Gln Gln Ala Ala
                485                 490                 495     
Gly Arg Gly Asn Leu Asp Gly Pro Val Arg Val His Gly Asn Leu Ala
            500                 505                 510         
Ile Gly Ile Gly Ile Gln Asn Phe Pro Glu Gly Leu Ala Val Ser Leu
        515                 520                 525             
Pro Leu Arg Gly Ala Gly Phe Ser Thr Trp Arg Ala Phe Trp Tyr Gly
    530                 535                 540                 
Gln Leu Ser Gly Met Val Glu Pro Leu Ala Gly Val Phe Gly Ala Phe
545                 550                 555                 560 
Ala Val Val Leu Ala Glu Pro Ile Leu Pro Tyr Ala Leu Ala Phe Ala
                565                 570                 575     
Ala Gly Ala Met Val Tyr Val Val Met Asp Asp Ile Ile Pro Glu Ala
            580                 585                 590         
Gln Ile Ser Gly Asn Gly Lys Leu Ala Ser Trp Ala Ser Ile Leu Gly
        595                 600                 605             
Phe Val Val Met Met Ser Leu Asp Val Gly Leu Gly
    610                 615                 620 


<210> 2887
<211> 1051
<212> PRT
<213> Homo sapiens

<400> 2887
Met Ala Glu Val Glu Ala Val Gln Leu Lys Glu Glu Gly Asn Arg His
 1               5                  10                  15      
Phe Gln Leu Gln Asp Tyr Lys Ala Ala Thr Asn Ser Tyr Ser Gln Ala
            20                  25                  30          
Leu Lys Leu Thr Lys Asp Lys Ala Leu Leu Ala Thr Leu Tyr Arg Asn
        35                  40                  45              
Arg Ala Ala Cys Gly Leu Lys Thr Glu Ser Tyr Val Gln Ala Ala Ser
    50                  55                  60                  
Asp Ala Ser Arg Ala Ile Asp Ile Asn Ser Ser Asp Ile Lys Ala Leu
65                  70                  75                  80  
Tyr Arg Arg Cys Gln Ala Leu Glu His Leu Gly Lys Leu Asp Gln Ala
                85                  90                  95      
Phe Lys Asp Val Gln Arg Cys Ala Thr Leu Glu Pro Arg Asn Gln Asn
            100                 105                 110         
Phe Gln Glu Met Leu Arg Arg Leu Asn Thr Ser Ile Gln Glu Lys Thr
        115                 120                 125             
Ile Val Met Ser Lys Trp Asp Asn Lys Cys Asn Gln Met Leu Arg Val
    130                 135                 140                 
Gln Phe Ser Thr Asp Ser Arg Val Gln Lys Met Phe Glu Ile Leu Leu
145                 150                 155                 160 
Asp Glu Asn Ser Glu Ala Asp Lys Arg Glu Lys Ala Ala Asn Asn Leu
                165                 170                 175     
Ile Val Leu Gly Arg Glu Glu Ala Gly Ala Glu Lys Ile Phe Gln Asn
            180                 185                 190         
Asn Gly Val Ala Leu Leu Leu Gln Leu Leu Asp Thr Lys Lys Pro Glu
        195                 200                 205             
Leu Val Leu Ala Ala Val Arg Thr Leu Ser Gly Met Cys Ser Gly His
    210                 215                 220                 
Gln Ala Arg Ala Thr Val Ile Leu His Ala Val Arg Ile Asp Arg Ile
225                 230                 235                 240 
Cys Ser Leu Met Ala Val Glu Asn Glu Glu Met Ser Leu Ala Val Cys
                245                 250                 255     
Asn Leu Leu Gln Ala Ile Ile Asp Ser Leu Ser Gly Glu Asp Lys Arg
            260                 265                 270         
Glu His Arg Gly Lys Glu Glu Ala Leu Val Leu Asp Thr Lys Lys Asp
        275                 280                 285             
Leu Lys Gln Ile Thr Ser His Leu Leu Asp Met Leu Val Ser Lys Lys
    290                 295                 300                 
Val Ser Gly Gln Gly Arg Asp Gln Ala Leu Asn Leu Leu Asn Lys Asn
305                 310                 315                 320 
Val Pro Arg Lys Asp Leu Ala Ile His Asp Asn Ser Arg Thr Ile Tyr
                325                 330                 335     
Val Val Asp Asn Gly Glu Lys Arg Gly Arg Phe Gly Ala Cys Ser Ser
            340                 345                 350         
Leu Leu Ser Gly His Gln Gly Thr Glu Gln Lys Met Glu Asp Val Arg
        355                 360                 365             
Leu Leu Lys Gly Ser Ser Val Leu Thr Glu Lys Met Arg Lys Gly Ile
    370                 375                 380                 
Gly Pro Ser Gly Ser Thr Ser Gly Pro Val Lys Val Gln Val Lys Ala
385                 390                 395                 400 
Leu Asn Ser Glu Pro Glu His Ala Gln Glu Val Pro Lys His Ile Pro
                405                 410                 415     
Lys Thr Cys Leu Arg Lys Ile Leu Lys Val Val Gly Gln Val Pro Asp
            420                 425                 430         
Leu Pro Ser Cys Leu Pro Leu Thr Asp Asn Thr Arg Met Leu Ala Ser
        435                 440                 445             
Ile Leu Ile Asn Lys Leu Tyr Asp Asp Leu Arg Cys Asp Pro Glu Arg
    450                 455                 460                 
Asp His Phe Arg Lys Ile Cys Glu Glu Tyr Ile Thr Gly Lys Phe Asp
465                 470                 475                 480 
Pro Gln Asp Met Asp Lys Asn Leu Asn Ala Ile Gln Thr Val Ser Gly
                485                 490                 495     
Ile Leu Gln Gly Pro Phe Asp Leu Gly Asn Gln Leu Leu Gly Leu Lys
            500                 505                 510         
Gly Val Met Glu Met Met Val Ala Leu Cys Gly Ser Glu Arg Glu Thr
        515                 520                 525             
Asp Gln Leu Val Ala Val Glu Ala Leu Ile His Ala Ser Thr Lys Leu
    530                 535                 540                 
Ser Arg Ala Thr Phe Ile Ile Thr Asn Gly Val Ser Leu Leu Lys Gln
545                 550                 555                 560 
Ile Tyr Lys Thr Thr Lys Asn Glu Lys Ile Lys Ile Arg Thr Leu Val
                565                 570                 575     
Gly Leu Cys Lys Leu Gly Ser Ala Gly Gly Thr Asp Tyr Gly Leu Arg
            580                 585                 590         
Gln Phe Ala Glu Gly Ser Thr Glu Lys Leu Ala Lys Gln Cys Arg Lys
        595                 600                 605             
Trp Leu Cys Asn Met Ser Ile Asp Thr Arg Thr Arg Arg Trp Ala Val
    610                 615                 620                 
Glu Gly Leu Ala Tyr Leu Thr Leu Asp Ala Asp Val Lys Asp Asp Phe
625                 630                 635                 640 
Val Gln Asp Val Pro Ala Leu Gln Ala Met Phe Glu Leu Ala Lys Ala
                645                 650                 655     
Gly Val Gly Glu Ser Gly Pro Thr Thr Asn Leu Arg Lys Glu Trp Ala
            660                 665                 670         
Leu Pro Ala Ala Leu Leu Arg His Gln Pro Ala Gly His Thr Ser Asp
        675                 680                 685             
Lys Thr Ile Leu Tyr Ser Val Ala Thr Thr Leu Val Asn Cys Thr Asn
    690                 695                 700                 
Ser Tyr Asp Val Lys Glu Val Ile Pro Glu Leu Val Gln Leu Ala Lys
705                 710                 715                 720 
Phe Ser Lys Gln His Val Pro Glu Glu His Pro Lys Asp Lys Lys Asp
                725                 730                 735     
Phe Ile Asp Met Arg Val Lys Arg Leu Leu Lys Ala Gly Val Ile Ser
            740                 745                 750         
Ala Leu Ala Cys Met Val Lys Ala Asp Ser Ala Ile Leu Thr Asp Gln
        755                 760                 765             
Thr Lys Glu Leu Leu Ala Arg Val Phe Leu Ala Leu Cys Asp Asn Pro
    770                 775                 780                 
Lys Asp Arg Gly Thr Ile Val Ala Gln Gly Gly Gly Lys Ala Leu Ile
785                 790                 795                 800 
Pro Leu Ala Leu Glu Gly Thr Asp Val Gly Lys Val Lys Ala Ala His
                805                 810                 815     
Ala Leu Ala Lys Ile Ala Ala Val Ser Asn Pro Asp Ile Ala Phe Pro
            820                 825                 830         
Gly Glu Arg Val Tyr Glu Val Val Arg Pro Leu Val Arg Leu Leu Asp
        835                 840                 845             
Thr Gln Arg Asp Gly Leu Gln Asn Tyr Glu Ala Leu Leu Gly Leu Thr
    850                 855                 860                 
Asn Leu Ser Gly Arg Ser Asp Lys Leu Arg Gln Lys Ile Phe Lys Glu
865                 870                 875                 880 
Arg Ala Leu Pro Asp Ile Glu Asn Tyr Met Phe Glu Asn His Asp Gln
                885                 890                 895     
Leu Arg Gln Ala Ala Thr Glu Cys Met Cys Asn Met Val Leu His Lys
            900                 905                 910         
Glu Val Gln Glu Arg Phe Leu Ala Asp Gly Asn Asp Arg Leu Lys Leu
        915                 920                 925             
Val Val Leu Leu Cys Gly Glu Asp Asp Asp Lys Val Gln Asn Ala Ala
    930                 935                 940                 
Ala Gly Ala Leu Ala Met Leu Thr Ala Ala His Lys Lys Leu Cys Leu
945                 950                 955                 960 
Lys Met Thr Gln Val Thr Thr Gln Trp Leu Glu Ile Leu Gln Arg Leu
                965                 970                 975     
Cys Leu His Asp Gln Leu Ser Val Gln His Arg Gly Leu Val Ile Ala
            980                 985                 990         
Tyr Asn Leu Leu Ala Ala Asp Ala Glu Leu Ala Lys Lys Leu Val Glu
        995                 1000                1005            
Ser Glu Leu Leu Glu Ile Leu Thr Val Val Gly Lys Gln Glu Pro Asp
    1010                1015                1020                
Glu Lys Lys Ala Glu Val Val Gln Thr Ala Arg Glu Cys Leu Ile Lys
1025                1030                1035                1040
Cys Met Asp Tyr Gly Phe Ile Lys Pro Val Ser
                1045                1050    


<210> 2888
<211> 494
<212> PRT
<213> Homo sapiens

<400> 2888
Met Asn Asp Asp Asp Thr Asp Val Cys Pro Asp Ser Ala Cys Cys Trp
 1               5                  10                  15      
Met Leu Val Glu Val Ser Gln Leu Asp Leu Gly Ser His Ser Phe His
            20                  25                  30          
Ser Ile Trp Ser Tyr Trp Gln Phe Leu Glu Cys Ala Lys Phe Ser Leu
        35                  40                  45              
Phe His Thr Phe Val Gln Ala Ile Pro His Ala Gly Ser Ala Ala Leu
    50                  55                  60                  
Pro Ala Pro Pro Pro Ile Pro His Val Gly Ser Ala Ala Leu Pro Ala
65                  70                  75                  80  
Pro Pro Pro Ile Pro His Ala Gly Gly Gln Thr Glu Ser Lys Gln Ser
                85                  90                  95      
Gly Phe Asp Cys Gln Leu Leu Val Ala Gln His Leu Gly Val Leu Gly
            100                 105                 110         
Ala His Gly Lys Leu Gln Val Pro Val His Ser Pro Pro Phe Leu Leu
        115                 120                 125             
Cys Leu Trp Leu Leu Leu Ser Glu Lys Arg Pro Glu Ala Leu Met Thr
    130                 135                 140                 
His Thr Lys Pro Val Cys Thr Ser Ser Phe Ser Gly Pro Ile Leu Ala
145                 150                 155                 160 
Leu Phe Leu Gly Pro Leu Leu Phe Lys Lys Lys Lys Asn Lys Val Val
                165                 170                 175     
Leu Val Leu Pro Glu Ser Glu Tyr Asn Leu Pro Gly Pro Arg Lys Asp
            180                 185                 190         
Ser Ala Met Ser Pro Ser Ala Met Ala Ser Lys His Gly Gly Pro Phe
        195                 200                 205             
Ile Gly Leu Ser Met Met Leu Gly Leu Val Leu Gln Val Gln Pro Val
    210                 215                 220                 
Ile Ser Gly Val Leu Ala Gly Gly Arg Gln Leu Asp Pro Arg Tyr Cys
225                 230                 235                 240 
Ala Ile Asn Tyr Gly Leu Lys Thr Thr Trp Gly Gly Trp Glu Lys Phe
                245                 250                 255     
Leu Asp Ser Thr Ser Pro Arg Lys Arg Pro Gly Leu Gly Ala Gly Val
            260                 265                 270         
Val Gln Thr Cys Ala Pro Val Leu Gln Glu Ala Pro Ser Glu Ala Glu
        275                 280                 285             
Phe Gly Gly Ser Glu Ala Thr Ser Glu Leu Asn Pro Ser Ser Val Glu
    290                 295                 300                 
Pro Pro Gly Val Thr Pro Ala Leu Pro Ser Ala Ala Cys Gly Leu Cys
305                 310                 315                 320 
Met Ser Val Thr Glu Ala Pro Ser Ala Ser Cys His Gln Met Asn Phe
                325                 330                 335     
Leu Leu Ser Asn Trp Ser Trp Arg Asn Gly Ala Ser Ile Gln Leu Leu
            340                 345                 350         
Arg Leu Glu Thr Leu Ile Lys Gly Gln Gln Val Asn Leu Leu Pro Phe
        355                 360                 365             
Ser Met Gln Ala Gly Ser Ser Ser Cys Pro Glu Glu Ser Leu Ala Thr
    370                 375                 380                 
Thr Leu Gly Ser Ala Gly Ala Gly His Thr Thr Val Ala Leu Phe Gln
385                 390                 395                 400 
Asp Phe Leu Phe Arg Gly Glu Ile Leu Ile Ile Pro Gly Asp Met Ser
                405                 410                 415     
Glu Leu Gln Thr Pro Thr Gly Pro Trp His Thr Leu Phe Met Phe Phe
            420                 425                 430         
His Arg Pro Asp Ala Asp Gly Leu Ser Cys Ile Arg Trp Cys Trp Gly
        435                 440                 445             
Leu Gly Ala Pro Ala Phe His Phe Ser Asp Gly Gln Phe Leu Ser Asp
    450                 455                 460                 
Leu Lys Leu Ser Pro Tyr Phe Met Val Glu Gly Glu Gly Gly Pro Val
465                 470                 475                 480 
Asp Arg Val Ile Ala Cys Arg Val Phe Arg Ala Phe Leu Asp
                485                 490                 


<210> 2889
<211> 116
<212> PRT
<213> Homo sapiens

<400> 2889
Met Ser Leu Asn Ile Ser His Ser Leu Ala Pro Pro Phe His Arg Leu
 1               5                  10                  15      
Pro Pro Ile Gly Asp Trp Leu Gly Leu Cys Arg Glu Glu Leu Glu Ile
            20                  25                  30          
Gly Ala Ile Gly Arg Arg Ala Asn Gln Ser His Gln Ser Phe His Arg
        35                  40                  45              
Gln Gln Arg Gly Arg Asn Thr Pro Ser Phe Pro Ser Gly Phe Pro Ser
    50                  55                  60                  
Pro Ser Leu Pro Pro Ser Pro Tyr Ser Tyr Gln Lys Arg Leu Ser Ser
65                  70                  75                  80  
Asp Trp Leu Glu Leu Cys Ala Ile Ser Ala Asn His Lys Pro Gly Cys
                85                  90                  95      
Ala Pro Thr Pro Ser Glu Glu Arg Ile Val Gln Arg Pro Cys Leu Arg
            100                 105                 110         
Leu Ala Ser Pro
        115     


<210> 2890
<211> 98
<212> PRT
<213> Homo sapiens

<400> 2890
Met Gly Trp Gly Leu Leu Arg Ala Val Glu Ala Gly Ser His Gly Leu
 1               5                  10                  15      
Thr Ala Gly Pro Gln Gly Gln Arg Met Gly Met Glu Met Trp Ala Ala
            20                  25                  30          
Ala Arg Leu Leu Asp Ala Ala Gly Ser Ser Ser Leu Pro Ala Ser Glu
        35                  40                  45              
Pro Lys Ser His Leu Ser Ser Tyr Lys Ala Thr Glu Thr Leu Ser Lys
    50                  55                  60                  
Glu Gly Pro Pro Ser Gly Arg Pro Leu Lys Ser Ser Pro Pro Pro Gln
65                  70                  75                  80  
Val Arg Asn Ala Ala Gly Arg Asn Pro Ala Val Ile Leu Asp Thr Thr
                85                  90                  95      
Leu Ile
        


<210> 2891
<211> 180
<212> PRT
<213> Homo sapiens

<400> 2891
Met Cys His Pro Leu Tyr Lys Leu Leu Ile Pro His Thr Arg Tyr Thr
 1               5                  10                  15      
Val Gln Ile Asn Ser Ile Gly Arg Ala Val Leu Leu Asn Glu Gly Gly
            20                  25                  30          
Leu Ser Ala Lys Gly Met Ser Leu Gly Val Glu Gly Phe Ala Gly Val
        35                  40                  45              
Met Val Arg Ala Leu Ser Glu Leu Thr Tyr Asp Ser Leu Tyr Leu Pro
    50                  55                  60                  
Asn Asp Phe Val Glu Arg Gly Val Gln Asp Leu Pro Gly Tyr Tyr Tyr
65                  70                  75                  80  
Arg Asp Asp Ser Leu Ala Val Trp Asn Ala Leu Glu Lys Tyr Val Thr
                85                  90                  95      
Glu Ile Ile Thr Tyr Tyr Tyr Pro Ser Asp Ala Ala Val Glu Gly Asp
            100                 105                 110         
Pro Glu Leu Gln Ser Trp Val Gln Glu Ile Phe Lys Glu Cys Leu Leu
        115                 120                 125             
Gly Arg Glu Ser Ser Ala Ser Gly Ser Leu Gly Gly Thr Gln Gly Arg
    130                 135                 140                 
Asn Pro Ser Ala Arg Gly Ala Leu Val Thr Pro Gly Ser Leu Tyr Lys
145                 150                 155                 160 
Val Arg Leu Ile Arg Cys His Arg Ser Arg Leu Arg Leu Arg Arg Phe
                165                 170                 175     
Ser Ser Arg Gly
            180 


<210> 2892
<211> 231
<212> PRT
<213> Homo sapiens

<400> 2892
Met Gly Asp Ala Gly Ala Thr Ala Ala Ala Leu Arg Pro Ala His Asn
 1               5                  10                  15      
Leu Arg Pro Ala Pro Pro Thr Ala Ser Ala Ala His Ala Gln Ser Ser
            20                  25                  30          
Arg Thr Ser Ala Pro Ser Ala Gln Arg Arg Leu Pro Ala Glu Pro Ser
        35                  40                  45              
His Arg Pro Ser Gly Thr Arg Thr Ser Leu Thr Arg Pro Leu Arg Thr
    50                  55                  60                  
Val Pro Cys Pro Ala Pro Leu Pro Gly Ser Gln Arg Val Gly Leu Met
65                  70                  75                  80  
Ile Pro Arg Pro Arg Ile His Pro His Pro Leu Leu Ala Pro Gly Thr
                85                  90                  95      
Ala Ser Thr Thr Pro Cys Ala Lys Trp Ser Ser Ser Cys Ala Ala Leu
            100                 105                 110         
Lys Gln Leu Lys Gly Pro Val Ser Asp Gln Glu Lys Leu Leu Val Tyr
        115                 120                 125             
Gly Leu Tyr Lys Gln Ala Thr Gln Gly Asp Cys Asp Ile Pro Gly Pro
    130                 135                 140                 
Pro Ala Ser Asp Val Arg Ala Arg Ala Lys Trp Glu Ala Trp Ser Ala
145                 150                 155                 160 
Asn Lys Gly Ala Ser Lys Met Asp Ala Met Arg Gly Tyr Ala Ala Lys
                165                 170                 175     
Val Glu Glu Leu Thr Lys Lys Glu Val Gly Gly Val Glu Arg Glu Gln
            180                 185                 190         
Arg Gly Val Gln Asp Gly Arg His Glu Gly Leu Arg Gly Gln Ser Gly
        195                 200                 205             
Gly Ala Asp Glu Glu Gly Arg Ala Ser Lys Met Asp Ala Met Arg Gly
    210                 215                 220                 
Tyr Ala Ala Arg Val Arg Arg
225                 230     


<210> 2893
<211> 798
<212> PRT
<213> Homo sapiens

<400> 2893
Met Pro Leu Pro Trp Ser Thr Ala Asn Lys Met His Ile Gln Leu Leu
 1               5                  10                  15      
Ser Ser His Pro Pro Met Pro Ser Pro Gln His Ser Phe Ser Lys Cys
            20                  25                  30          
Phe Ser Cys Pro Ala Leu Ala Asp Ala Glu Asp Val Lys Met Ser Asn
        35                  40                  45              
Met Pro Ala Leu Pro Ser Lys Ala Pro Ala Ser Gln Asp Asp Leu Pro
    50                  55                  60                  
Arg Cys Phe Tyr Leu Ala Ala Leu Asp Ser Ser Thr Pro Pro Met Lys
65                  70                  75                  80  
Asn Arg Ala Lys Pro Pro Asp Phe Ser Glu Pro Leu Ser Gln Leu Pro
                85                  90                  95      
Asp Leu Thr Ala Ala Arg Ile Phe Glu Ser Cys Met Ser Asp Thr Ser
            100                 105                 110         
Gly Lys Asp Cys Thr Leu Leu Arg Ser His Arg Glu Val Leu Asp Pro
        115                 120                 125             
Ser Leu Ser Ser Ser Phe Ser Asn Phe Gln Glu Lys Thr Ala Arg Ile
    130                 135                 140                 
Leu Ala Ser Ser Phe Ala Ala Gly Val Arg Arg Ser Leu Arg Ala Arg
145                 150                 155                 160 
Ala Ser Pro Ala Ala Pro Leu Ser Glu Ser Arg Gly Gly Ala Ala Pro
                165                 170                 175     
Ala Gly Phe Lys Gly Thr Ala Pro Ala Glu Ala Arg Gly Pro Gly Gly
            180                 185                 190         
Arg Arg Phe Ser Gly Leu Leu Thr Pro Ser Ala Ala Arg Pro Asp Pro
        195                 200                 205             
Pro Ala Pro Pro Ala Gln Ala Trp Asp Arg Arg Gly Ser Val Thr Pro
    210                 215                 220                 
Thr Gly Ala Pro Ile Trp Glu Leu Val Ser Arg Val His Gly Tyr Gln
225                 230                 235                 240 
Lys Glu Val Val Phe Thr Arg Asn Arg Asp Leu Leu Ser Lys Leu Gly
                245                 250                 255     
Val Cys Ala Leu Glu Glu Gly Lys Asp Glu Leu Gly Leu Gln Leu Lys
            260                 265                 270         
Glu Gly Gln Glu Lys Glu Glu Met Lys Cys His Asp Ile Arg Pro Arg
        275                 280                 285             
Pro Ser Gln Arg Thr Leu Thr Arg Leu Pro Ala Arg Asp Cys Gln Pro
    290                 295                 300                 
Cys Leu Trp Val Pro Ser Gly Gly Leu Ser Ala Gly Glu Pro Arg Arg
305                 310                 315                 320 
Leu Leu Arg Gln Ser Val Arg Glu Lys Glu Glu Ala Leu Gly Tyr Cys
                325                 330                 335     
His Leu Val Gln Arg Ala Tyr Lys Arg Lys Ala Ala Pro Val Pro Gly
            340                 345                 350         
Leu Leu Arg Phe Lys Thr Ala Pro Thr Ala Ala Glu Ile Thr Gly His
        355                 360                 365             
Ala Lys Ala Asp Asn Ile Ser Val Phe Val Gln Cys Val Phe Glu Glu
    370                 375                 380                 
Ser Gly Gln Asp Ser Lys Gly Val Leu Glu Ile Leu Met Leu Glu Arg
385                 390                 395                 400 
Trp Asn Phe Ile Leu Ala Lys Asp Ser Gly Asp Arg Arg Pro Ile Lys
                405                 410                 415     
Pro Glu Asp Met Asp Lys Tyr Ala Lys Pro Ala Thr Thr Gly Leu Gly
            420                 425                 430         
His Lys Asn Lys Lys Val Thr His Lys Phe Ser Pro Pro Lys Asp Glu
        435                 440                 445             
Asp Asn Thr Leu Ile Arg Ala Glu Arg Ile Leu Ser Arg Glu Glu Glu
    450                 455                 460                 
Ser Gln Gly Leu Thr Val Lys Ile Thr Gly Pro Gly Ser Gly Trp Ser
465                 470                 475                 480 
Arg Glu Asp Tyr Lys Ser Val Pro Leu Lys Thr Glu Asp Glu Glu Tyr
                485                 490                 495     
Met Leu Ala Leu Lys Gln Glu Leu Arg Glu Thr Met Lys Arg Met Pro
            500                 505                 510         
Tyr Phe Ile Glu Thr Pro Glu Glu Arg Gln Asp Ile Glu Arg Tyr Ser
        515                 520                 525             
Lys Arg Tyr Met Lys Val Leu Trp Pro Gln Tyr Trp Lys Met Gln Leu
    530                 535                 540                 
Met Thr Ile Ser Gly Tyr Arg Gly Pro Ser Val Tyr Gly Ser Tyr His
545                 550                 555                 560 
Gln Gln Val Ser Leu Leu Thr Phe Thr Leu Leu Ser Tyr Lys Thr Gly
                565                 570                 575     
Val Thr Ala Ala Thr Phe Trp Pro Ser Val Gly Pro Cys Ala Ser Pro
            580                 585                 590         
Asn Gly Pro Ala Gly Glu Phe Ser Ala Ser Ala Thr Ala Ala Ile Gly
        595                 600                 605             
Lys Lys Ala Ser Met Ser Leu Leu Ala Val Ser Val Phe Ser Ile Gly
    610                 615                 620                 
Gln Lys Pro Lys Ser Gly Pro Gln Glu Ala Ser Pro Glu Ser Leu Thr
625                 630                 635                 640 
Cys Cys Lys Ser Gly Phe Gly Tyr Asn Gln Glu Val Asp Gly Asp Asp
                645                 650                 655     
Thr Gly Glu Gly Gly Glu Gly Pro Cys Ala Ser Ala Cys Pro Asn Arg
            660                 665                 670         
Ser Gln Arg Thr Glu Leu Lys Pro Arg Pro Leu Thr Pro Glu Val Pro
        675                 680                 685             
Asp Asp His Tyr Gly Thr Ala Gln Pro Met Thr His Ser Gly Val Val
    690                 695                 700                 
His Leu Gly Thr His Met Lys His Ile Gln Asp Leu Pro Leu Gly Lys
705                 710                 715                 720 
Lys Glu Lys Ser Thr Tyr Leu Leu Ala Pro Ser Arg His Trp Lys His
                725                 730                 735     
Val Pro Glu Asp Asp Glu Asp Leu Thr Ile Glu Ser Ala Leu His Leu
            740                 745                 750         
Ser Pro Ala Leu Lys His Cys His Pro Cys Gly Met Pro Val Thr Gln
        755                 760                 765             
Tyr Val Lys Thr Asn Asn Asp Asn Arg Gly Pro Ala Arg Pro Arg Arg
    770                 775                 780                 
Lys Pro Leu Glu Pro Pro Ala Arg Pro Arg Leu Glu Pro Pro
785                 790                 795             


<210> 2894
<211> 505
<212> PRT
<213> Homo sapiens

<400> 2894
Met Glu Arg Glu Lys Leu Glu Arg Phe Val Ile Glu Pro Gln Tyr Ser
 1               5                  10                  15      
Trp Gly Ala Phe Ser Thr Arg Leu Asn Gly Arg Gln Val Gln Leu Glu
            20                  25                  30          
Ala His Phe Ile Phe Ser Asp Gln Gly Ile Val Gly Met Glu Phe Asn
        35                  40                  45              
Phe Ile Glu Lys Tyr Lys Ile Ser Arg Arg Thr Leu Gly Phe Cys His
    50                  55                  60                  
Cys Arg Gly Met Leu Ser Asp Ala Val Gly Trp Gly Arg Leu Trp Lys
65                  70                  75                  80  
Ser His Ala Pro Asp Arg Val Pro Gly Arg Pro Ser Pro Glu Ala Arg
                85                  90                  95      
Pro Gly Ala Arg Leu Arg Gly Pro Gly Arg Leu Glu Leu Pro Val Ala
            100                 105                 110         
Arg Thr Leu Arg Leu Arg Asp Trp Arg Cys Glu Ala Asp Ala Gly Gly
        115                 120                 125             
Glu Ala Pro Gly Pro Val Cys Glu Ser Gly Thr Ala Ala Gly Leu Ser
    130                 135                 140                 
Thr Gln Arg Pro Glu Leu Ala Glu Leu Ile Ser Gly Asp Ala Gly Asn
145                 150                 155                 160 
Val Arg Ile Ala Ser Ser Met Gly Glu Ile Lys Leu Ser Gly Pro Leu
                165                 170                 175     
Gln Phe Asn Leu Glu Phe Asn Asn Asp Cys Gly Asn Lys Asn Asn Glu
            180                 185                 190         
Ser Asp Asp Asn Asn Asn Asp Gly Lys Thr Arg Met Ala Ala Val Pro
        195                 200                 205             
Gln Ile Pro Met Ser Thr Cys Ala Pro Glu Val Ala Ala Arg Ala Gly
    210                 215                 220                 
Ala His Phe Arg Gly Glu Gly Pro Gln Ala Gln Ala Pro Gly Asp Gly
225                 230                 235                 240 
Val Cys Pro Gly Ser Thr Leu Cys Trp Arg Ile Gln Arg Ile Gln Ala
                245                 250                 255     
Asn Ile Leu Gly Arg Ile Met Ala Val Leu Arg Ala Leu Thr Ala Phe
            260                 265                 270         
Glu Met Cys Pro Val Gly Val Met Phe Leu Gln Leu Gly Leu His Ala
        275                 280                 285             
Arg Ser Arg Phe Leu Arg Asn Pro Ile Gly Ser Phe Thr Asn Asn Arg
    290                 295                 300                 
Asp Leu Leu Pro Asp Pro Ser Ala Ala Ser Thr Arg Ser Lys Asp Leu
305                 310                 315                 320 
Met Ser Ser Gly Ala Asp Phe Ile Glu Arg His Pro Pro Pro Glu Trp
                325                 330                 335     
Leu Leu Glu Cys Gly Thr Pro Gly Cys Pro Leu Val Val Ala Ser Tyr
            340                 345                 350         
Asp Leu His Trp Arg Met Ala Val Arg Ser Lys His Leu Ser Leu Lys
        355                 360                 365             
Arg Gly Asn Glu Gly Lys Thr Pro Gly Asp Gln Gln Leu Val Val His
    370                 375                 380                 
Gly Val Ser Asn Thr Gly Leu Asp Thr Ala Pro Cys Val Ala His Arg
385                 390                 395                 400 
Lys His Leu Arg Asn Gly Ser Ala Arg Ala Arg Thr Val Ser Ser Ser
                405                 410                 415     
Thr Gln Phe Pro Arg Phe Ile Thr Gln Phe Ser Thr Gln Phe Leu Phe
            420                 425                 430         
His Lys Ile Asn Lys Phe Arg Trp Thr Pro Gly Leu His Gly Trp Asp
        435                 440                 445             
Met Pro Trp Arg Ala Leu Val Ala Gly Ala Ala Val Gly Ser Gly Ala
    450                 455                 460                 
Ala Val Ala Gln Asn Ser Ala Gly Lys Gly Glu Ser Ser Gly Ser Gln
465                 470                 475                 480 
His Phe Gly Lys Lys Pro Phe Pro Thr Phe Gln Tyr Gly Ser Ala Arg
                485                 490                 495     
Phe Arg Leu Leu Phe Asp Arg Leu Cys
            500                 505 


<210> 2895
<211> 389
<212> PRT
<213> Homo sapiens

<400> 2895
Met Glu Lys Gln Leu Arg Glu Lys Met Ala Val Trp Leu Pro Leu Ala
 1               5                  10                  15      
Cys Leu Leu Glu Thr Ile Cys Leu Val Pro Met Gly Trp Ser Gly Val
            20                  25                  30          
Asp Gly Val Glu Lys Phe Pro Trp Pro Ser Glu Arg Glu Pro Arg Leu
        35                  40                  45              
Phe Lys Thr Arg Thr Tyr Lys Val Ser Pro Ser His Gln Lys Leu Ala
    50                  55                  60                  
Ala Leu Arg Ser Leu Ser Asp Leu Leu Ala Arg Phe Ser Arg Ser Arg
65                  70                  75                  80  
Arg Ala Ala Gln Ala Arg Arg Leu Arg Val Gln Leu Ala Leu Cys Gly
                85                  90                  95      
Arg Trp Ser Arg Pro Ala Ala Leu Thr Asn Tyr Ser Arg Leu Val Thr
            100                 105                 110         
Arg Asp Lys Leu Leu Ala Ala Ala Gln Pro Leu Pro Gln Ser Pro Ser
        115                 120                 125             
Pro Glu Pro Ala Thr Lys Ile Glu Asp Ala Ala Gly Ala Arg Ser Ser
    130                 135                 140                 
Gly Pro Gly Ser Arg Ala Gly Glu Gly Glu Arg Arg Arg Ala Gln Gln
145                 150                 155                 160 
Pro Glu Pro Arg Glu Asp Phe Gly Ser Ala Gly Ser Pro Ser Ala Pro
                165                 170                 175     
Ser Ala Ser Gly Ala Arg Arg Arg Val Gly Pro Gly Thr Gly Glu Glu
            180                 185                 190         
Asp Pro Gly Pro Cys Ala Arg Ala Pro Gly Ala Ala Gly Val Arg Thr
        195                 200                 205             
Ser Ala Thr Arg Ser Pro Gly Thr Gly Gly Arg Ser Gly Gly Gly Asp
    210                 215                 220                 
Leu Pro Val Pro Cys Pro Pro Cys Arg Pro Leu Pro Gly Ala Ala Gly
225                 230                 235                 240 
Asp Pro Gly Arg Ser Pro Arg Ser Cys Ser Val Cys Gly Glu Ala Gly
                245                 250                 255     
Gly Ser Ser Ser Pro Val Pro Ala Val Gly Leu Gly Gly Arg Gly Gly
            260                 265                 270         
Lys Arg Ala Gly Pro Gln Ala Leu Ala Thr Ala Leu Arg Pro Ala Gly
        275                 280                 285             
Leu Pro Leu Pro Thr Leu Val Pro Leu Ala Glu Arg Arg Gly Gln Leu
    290                 295                 300                 
Gln Leu Val His Pro Ala Arg Leu Pro Gly Gly Pro Arg Trp Glu Gly
305                 310                 315                 320 
Glu Ala Leu Ala Val Cys Glu Gln Ala Cys Glu Cys Val Arg Val Cys
                325                 330                 335     
Ala Cys Thr Arg Ala Arg Gly Arg Ser Lys Pro Arg Gly Thr Pro His
            340                 345                 350         
Gly Glu Asp Leu Trp Ile Gly Val Gly Gly Pro Ala Trp Gly Arg Thr
        355                 360                 365             
Arg His Ala Val Thr Gly Val Tyr Asn Gln Asp Asp Leu Tyr Tyr Leu
    370                 375                 380                 
Gly Asp Thr Gly Gly
385                 


<210> 2896
<211> 256
<212> PRT
<213> Homo sapiens

<400> 2896
Met Val Leu Asn Glu Ser His Ser Glu Gly Ser Arg Val Ile Ala Asn
 1               5                  10                  15      
Asn Thr Glu Ser Ile Pro Met Pro Tyr Asp His Val Lys Leu Thr Phe
            20                  25                  30          
Ser Asp Met Asn Asn Val Pro Glu Ala Ser Lys Gly Thr Lys Lys Gly
        35                  40                  45              
Thr Ile Tyr Leu Thr Pro Phe Ile Phe Leu Ser Arg Ala Lys Asp Ala
    50                  55                  60                  
Thr Gln Ser Phe Val Met Ser Phe Tyr Leu Leu Lys Ala Tyr Glu Ile
65                  70                  75                  80  
Lys Gln Pro Val Phe Asp Thr Asn Cys Ile Lys Gly Thr Val Asn Thr
                85                  90                  95      
Glu Ala Gly Gly Gly Trp Glu Gly Ser Ala Ser Gly Lys Ser Ala Phe
            100                 105                 110         
Thr Ala Gly Gly Ala Thr Glu Ser Gly Gln Gln Val Leu Gln Val Thr
        115                 120                 125             
Ser Gln Ala Ser Arg Gly Glu Ala Leu Ser Gly Ala Tyr Gly His Ser
    130                 135                 140                 
His Val Pro Gly Arg Thr Cys Val Phe Pro Pro Pro Val Thr Ser Gly
145                 150                 155                 160 
Met Tyr Pro Cys Pro Pro Gly Cys Pro Ser Pro Pro Pro Ser Pro Glu
                165                 170                 175     
Phe Tyr Pro Gly Pro Pro Lys Met Asp Arg Ala Met Gly Tyr Val Gln
            180                 185                 190         
Pro Pro Pro Leu Pro Cys Pro Gly Pro Met Glu Pro Pro Val Ser Pro
        195                 200                 205             
Asp Val Pro Cys Thr Pro Ala Ala Glu Ala Arg Ala Thr Lys Ala Ala
    210                 215                 220                 
Ala Ser Thr Tyr Tyr Asn Pro Gly Lys Pro His His Val Ser Met Pro
225                 230                 235                 240 
Thr Lys Gln Pro Pro Pro Ser Tyr Pro Arg Glu Asp Lys Lys Thr Gln
                245                 250                 255     


<210> 2897
<211> 161
<212> PRT
<213> Homo sapiens

<400> 2897
Met His Ser Pro Pro Gly Val Ser Thr Ala Gly Ile Gln Lys Gln Val
 1               5                  10                  15      
Ser Thr Pro Ser Arg Gly Asn Tyr Ser Thr Gly Pro Pro Val Ala Leu
            20                  25                  30          
Ala Thr Gly Ala Ser Pro Glu Asp Ser Ala Cys Asp Lys Ile Pro Arg
        35                  40                  45              
Met Leu Gln Leu Gly Ala Glu Leu Arg Pro Leu Ile Ile Thr Val Lys
    50                  55                  60                  
Cys Gly Gln Pro Asn Gly Ser Arg Ser Ile Met Lys Arg Val Cys Met
65                  70                  75                  80  
Ile Thr Val Cys Arg Arg Ser Pro Thr Thr Thr Ser Val Val Ile Ala
                85                  90                  95      
Lys Leu Leu Ser Gln Gly Leu Ser Val Asn Arg Ala Leu Pro Arg Pro
            100                 105                 110         
Ile Gln Glu Cys Arg Leu Thr Glu Arg Ser Ala Arg Ile Ser Ala Ser
        115                 120                 125             
Gly Arg Ala Val Ala Ser Lys Ser Pro Phe Thr Asn Leu Glu Glu Lys
    130                 135                 140                 
Gln Trp Val Asn Gln Ala Thr Val Cys Gly Met Pro Asp Glu Asn Lys
145                 150                 155                 160 
Asn
    


<210> 2898
<211> 129
<212> PRT
<213> Homo sapiens

<400> 2898
Met Ile His Ser Val Ser Ala Ala Ser Leu Pro Thr Pro Val Gly Ser
 1               5                  10                  15      
Ser Leu Ser Ala Ser Val Arg His Gln His Leu Ser Val Ile Gly Ile
            20                  25                  30          
Cys Leu Ser Arg Val Ile Cys Arg Thr Thr Leu Arg Thr His Glu Cys
        35                  40                  45              
Gln Met Ser Pro Val Ser Trp Pro Thr Arg Ile Ser Ser Ser Trp Leu
    50                  55                  60                  
Lys Lys Gln Pro Gln Thr Ala Thr Thr Gly Pro Val Pro Asn Ser His
65                  70                  75                  80  
Asp Ile Pro Val Glu Arg Arg Lys His Leu Leu Asn Met Phe Leu Leu
                85                  90                  95      
Cys Gly Ala Ser Ser Lys His Pro Ser Lys Ala Glu Gly Gly Leu Ser
            100                 105                 110         
Leu His Cys Pro Lys His Leu Val Ile Cys Gln Val His Thr Trp Gln
        115                 120                 125             
Cys
    


<210> 2899
<211> 153
<212> PRT
<213> Homo sapiens

<400> 2899
Met Ser Pro Pro Thr Pro Lys Gly Gly Gly Lys Gly Gly Gly Leu Arg
 1               5                  10                  15      
Ser Pro Leu Cys Gly Arg Gly Arg Trp Arg Trp Arg Trp Asn Arg Lys
            20                  25                  30          
Gly Val Glu Gly Gly Gly Gln Glu Gly Ser Ala Asp Gly Glu Ala Lys
        35                  40                  45              
Ala Thr Leu Lys Leu Val Leu Ala Val Ile Gln Glu Gly Pro Lys Gly
    50                  55                  60                  
Gln Cys Gln Gly Gln Gly Trp Glu Leu Leu Leu Gln Arg Gly Thr His
65                  70                  75                  80  
Asp Pro Val Ala Ile His Arg Ala Phe Glu Glu Glu Val Gly Leu Gly
                85                  90                  95      
Gln Val Gln Leu Val Pro Glu Gly Asp Ala Gly Val Leu His Pro Cys
            100                 105                 110         
Ala Gly Leu Lys Leu His Thr His Leu Gln Leu Val Thr Gly Phe Val
        115                 120                 125             
Val Val Cys Cys Val His Ala Arg Leu Ala Gln Arg Tyr Arg Cys Gln
    130                 135                 140                 
Pro Val Val His Cys Val Phe Pro Ser
145                 150             


<210> 2900
<211> 790
<212> PRT
<213> Homo sapiens

<400> 2900
Met Ala Tyr Cys Leu Thr Asn Cys Tyr Gln Tyr Ser Val Thr Phe Glu
 1               5                  10                  15      
Asp Thr Ala Val Asp Phe Thr Gln Glu Glu Trp Ile Leu Leu Asp Pro
            20                  25                  30          
Val Gln Arg Asn Leu Tyr Arg Asp Val Met Leu Glu Asn Tyr Glu Asn
        35                  40                  45              
Val Ala Lys Val Gly Phe Gln Leu Phe Lys Pro Ser Val Ile Ser Trp
    50                  55                  60                  
Leu Glu Glu Glu Glu Leu Arg Thr Leu Gln Gln Gly Val Leu Gln Asp
65                  70                  75                  80  
Trp Ala Ile Lys His Gln Thr Ser Val Ser Ala Leu Gln Gln Glu Phe
                85                  90                  95      
Trp Lys Ile Gln Thr Ser Asn Gly Ile Gln Met Asp Leu Val Thr Phe
            100                 105                 110         
Asp Ser Val Ala Val Glu Phe Thr Gln Glu Glu Trp Thr Leu Leu Asp
        115                 120                 125             
Pro Ala Gln Arg Asn Leu Tyr Ser Asp Val Met Leu Glu Asn Tyr Lys
    130                 135                 140                 
Asn Leu Ser Ser Val Gly Tyr Gln Leu Phe Lys Pro Ser Leu Ile Ser
145                 150                 155                 160 
Trp Leu Glu Glu Glu Glu Glu Leu Ser Thr Leu Pro Arg Val Leu Gln
                165                 170                 175     
Glu Trp Lys Met Cys Leu Lys Thr Lys Gly Pro Ala Leu Trp Gln Asp
            180                 185                 190         
Asn Phe Cys Leu Lys Thr Leu Asn Gly Ile Gln Leu Ala Arg Asn Gln
        195                 200                 205             
Asn Gly Glu Glu Leu Tyr Asp Cys Lys Gln Cys Glu Asp Val Phe Cys
    210                 215                 220                 
Lys His Pro Cys Leu Lys Thr Asn Met Ser Thr Gln Asn Arg Gly Asn
225                 230                 235                 240 
Thr Ser Glu Cys Ile Gln Tyr Ala Lys Asp Leu Leu Ser Leu Tyr Asn
                245                 250                 255     
Lys Thr Ser Thr Ile Arg Lys Val Ser Val Phe Ser Lys His Gly Lys
            260                 265                 270         
Ser Phe Arg Leu Ile Leu Asn Val Gln Val Gln Arg Lys Cys Thr Gln
        275                 280                 285             
Asp Lys Ser Phe Glu Gly Thr Asp Tyr Gly Lys Ala Phe Ile Tyr Gln
    290                 295                 300                 
Ser Tyr Leu Glu Ala His Arg Lys Thr Gln Ser Gly Glu Lys Leu Asn
305                 310                 315                 320 
Glu Trp Lys Gln Cys Gly Glu Ala Phe Thr His Ser Thr Ser His Ala
                325                 330                 335     
Val Asn Val Glu Thr His Ile Ile Lys Asn Pro Tyr Glu Cys Lys Glu
            340                 345                 350         
Cys Gly Lys Asp Phe Arg Tyr Pro Thr His Leu Asn Asn His Met Gln
        355                 360                 365             
Thr His Ile Gly Ile Lys Pro Tyr Lys Cys Lys His Cys Gly Lys Thr
    370                 375                 380                 
Phe Thr Val Pro Ser Gly Phe Leu Glu His Val Arg Thr His Thr Gly
385                 390                 395                 400 
Glu Lys Pro Tyr Gly Cys Lys Glu Cys Gly Lys Ala Phe Gly Thr Ser
                405                 410                 415     
Ala Gly Leu Ile Glu His Ile Arg Cys His Ala Arg Glu Lys Thr Phe
            420                 425                 430         
Lys Cys Asp His Cys Gly Lys Ala Phe Ile Ser Tyr Pro Ser Leu Phe
        435                 440                 445             
Gly His Leu Arg Val His Asn Gly Glu Lys Pro Tyr Glu His Lys Glu
    450                 455                 460                 
Tyr Gly Lys Ala Phe Gly Thr Ser Ser Gly Val Ile Glu Asp Arg Arg
465                 470                 475                 480 
Ser Asn Thr Gly Gln Lys Arg Phe Asp Cys Asp Gln Cys Gly Lys Val
                485                 490                 495     
Phe Val Ser Phe Ser Ser Leu Phe Ala His Leu Arg Thr His Thr Gly
            500                 505                 510         
Glu Lys Pro Phe Lys Cys Tyr Lys Cys Gly Lys Pro Phe Thr Ser Ser
        515                 520                 525             
Ala Cys Leu Arg Ile His Met Arg Thr His Thr Glu Glu Arg Leu Tyr
    530                 535                 540                 
Gln Cys Lys Lys Cys Gly Lys Ala Phe Thr Lys Cys Ser Tyr Leu Thr
545                 550                 555                 560 
Lys His Leu Arg Thr His Ala Gly Glu Lys Pro Tyr Glu Cys Met Lys
                565                 570                 575     
Cys Gly Lys Ala Phe Thr Glu Arg Ser Tyr Leu Thr Lys His Leu Arg
            580                 585                 590         
Arg His Ser Gly Glu Lys Pro Tyr Glu Cys Lys Lys Cys Gly Lys Ala
        595                 600                 605             
Phe Thr Glu Arg Ser Asp Leu Thr Lys His Leu Arg Arg His Thr Gly
    610                 615                 620                 
Asp Lys Pro Tyr Glu Tyr Lys Asp Cys Gly Lys Ala Phe Val Val Ser
625                 630                 635                 640 
Ser Ser Leu Val Asp His Leu Arg Thr His Thr Gly Tyr Lys Pro Tyr
                645                 650                 655     
Lys Cys Asn Ala Cys Glu Lys Ala Tyr Ser Arg Ser Cys Val Leu Thr
            660                 665                 670         
Gln His Leu Lys Thr His Ala Ala Glu Lys Thr Ser Glu Cys Asn Ala
        675                 680                 685             
Cys Gly Asn Ser Phe Arg Asn Ser Met Cys Phe His Asp Arg Leu Lys
    690                 695                 700                 
Thr Leu Thr Lys Ile Lys Pro Tyr Lys Cys Lys Asp Cys Gly Lys Ala
705                 710                 715                 720 
Phe Thr Cys His Ser Asp Leu Thr Asn His Val Arg Ile His Thr Gly
                725                 730                 735     
Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly Lys Ala Phe Arg Thr Ser
            740                 745                 750         
Ser Gly Arg Ile Gln His Leu Arg Thr His Met Gly Glu Lys Pro Phe
        755                 760                 765             
Glu Cys Asp Gln Cys Gly Lys Ala Phe Ala Ser Phe Ser Ala Arg Ile
    770                 775                 780                 
Ala His Leu Lys Thr His
785                 790 


<210> 2901
<211> 426
<212> PRT
<213> Homo sapiens

<400> 2901
Met Lys Asn Glu Tyr Lys Glu Leu Asn Asp Ala Tyr Thr Ala Ala Ala
 1               5                  10                  15      
Arg Arg His Thr Val Val Leu Glu Gly Pro Asp Gly Ile Gly Lys Thr
            20                  25                  30          
Thr Leu Leu Arg Lys Val Met Leu Asp Trp Ala Glu Gly Asn Leu Trp
        35                  40                  45              
Lys Asp Arg Phe Thr Phe Val Phe Phe Leu Asn Val Cys Glu Met Asn
    50                  55                  60                  
Gly Ile Ala Glu Thr Ser Leu Leu Glu Leu Leu Ser Arg Asp Trp Pro
65                  70                  75                  80  
Glu Ser Ser Glu Lys Ile Glu Asp Ile Phe Ser Gln Pro Glu Arg Ile
                85                  90                  95      
Leu Phe Ile Met Asp Gly Phe Glu Gln Leu Lys Phe Asn Leu Gln Leu
            100                 105                 110         
Lys Ala Asp Leu Ser Asp Asp Trp Arg Gln Arg Gln Pro Met Pro Ile
        115                 120                 125             
Ile Leu Ser Ser Leu Leu Gln Lys Lys Met Leu Pro Glu Ser Ser Leu
    130                 135                 140                 
Leu Ile Ala Leu Gly Lys Leu Ala Met Gln Lys His Tyr Phe Met Leu
145                 150                 155                 160 
Arg His Pro Lys Leu Ile Lys Leu Leu Gly Phe Ser Glu Ser Glu Lys
                165                 170                 175     
Lys Ser Tyr Phe Ser Tyr Phe Phe Gly Glu Lys Ser Lys Ala Leu Lys
            180                 185                 190         
Val Phe Asn Phe Val Gly Ile Phe Met Phe Gly Ile Ser Thr Glu Glu
        195                 200                 205             
Ile Val Ser Met Leu Glu Thr Ser Phe Gly Phe Pro Leu Ser Lys Asp
    210                 215                 220                 
Leu Lys Gln Glu Ile Thr Gln Cys Leu Glu Ser Leu Ser Gln Cys Glu
225                 230                 235                 240 
Ala Asp Arg Glu Ala Ile Ala Phe Gln Glu Leu Phe Ile Gly Leu Phe
                245                 250                 255     
Glu Thr Gln Glu Lys Glu Phe Val Thr Lys Val Met Asn Phe Phe Glu
            260                 265                 270         
Glu Val Phe Ile Tyr Ile Gly Asn Ile Glu His Leu Val Ile Ala Ser
        275                 280                 285             
Phe Cys Leu Lys His Cys Gln His Leu Thr Thr Leu Arg Met Cys Val
    290                 295                 300                 
Glu Asn Ile Phe Pro Asp Asp Ser Gly Cys Ile Ser Asp Tyr Asn Glu
305                 310                 315                 320 
Lys Leu Val Tyr Trp Arg Glu Leu Cys Ser Met Phe Ile Thr Asn Lys
                325                 330                 335     
Asn Phe Gln Ile Leu Asp Met Glu Asn Thr Ser Leu Asp Asp Pro Ser
            340                 345                 350         
Leu Ala Ile Leu Cys Lys Ala Leu Ala Gln Pro Val Cys Lys Leu Arg
        355                 360                 365             
Lys Leu Ile Phe Thr Ser Val Tyr Phe Gly His Asp Ser Glu Leu Phe
    370                 375                 380                 
Lys Ala Val Leu His Asn Pro His Leu Lys Leu Leu Ser Leu Tyr Gly
385                 390                 395                 400 
Thr Ser Leu Ser Gln Ser Asp Ile Arg His Leu Cys Glu Thr Leu Lys
                405                 410                 415     
His Pro Met Cys Lys Ile Glu Glu Leu Met
            420                 425     


<210> 2902
<211> 975
<212> PRT
<213> Homo sapiens

<400> 2902
Met Lys Leu Asp Ile Glu Gln Tyr Arg Met Val Thr Glu Ala Leu Asp
 1               5                  10                  15      
Glu Arg Ala Asn Leu Pro Glu Ile Ser Pro His Leu Ser Ala Pro Leu
            20                  25                  30          
Pro Ile Met Leu Pro Val Tyr Lys Trp Trp Gln Leu Pro Tyr Tyr Trp
        35                  40                  45              
Val Gly Ile Lys Leu Tyr Asp Leu Val Ala Gly Ser Asn Cys Leu Lys
    50                  55                  60                  
Ser Ser Tyr Val Leu Ser Lys Ser Arg Ala Leu Glu His Phe Pro Met
65                  70                  75                  80  
Leu Gln Lys Asp Lys Leu Val Gly Gly Ile Val Tyr Tyr Asp Gly Arg
                85                  90                  95      
His Asn Asp Ala Trp Met Asn Leu Ala Ile Val Leu Thr Ala Ala Arg
            100                 105                 110         
Tyr Gly Asp Ala Thr Val Asn Asp Arg Glu Val Val Ser Leu Leu Lys
        115                 120                 125             
Lys Thr Asp Thr Gln Thr Asp Ser Glu Ser Ala Trp Gln Glu Phe Asp
    130                 135                 140                 
Met Lys Ala Lys Cys Val Ile Asn Ala Val Gly His Phe Thr Asp Ser
145                 150                 155                 160 
Val Cys Lys Ile Asp Asp Lys Asp Ala Ala Ala Ile Cys Gln Pro Thr
                165                 170                 175     
Ala Gly Val His Ile Val Met Pro Ala Gln Arg Ala Trp Asp Phe Leu
            180                 185                 190         
Thr Ser Asp Gly Arg Val Ile Phe Phe Leu Pro Trp Gln Lys Met Met
        195                 200                 205             
Ile Ala Gly Thr Thr Asp Thr Pro Thr Asp Ile Thr His His Pro Ser
    210                 215                 220                 
Pro Ser Glu Glu Asp Ile Asn Phe Ile Leu Asn Glu Ala Arg Gly Lys
225                 230                 235                 240 
Asp Trp Asn Pro Thr Leu Tyr Met Lys Leu Val Gln Asp Tyr Gly Leu
                245                 250                 255     
Glu Ser Glu Gly Ala Gln His Leu Ala Ala Thr Tyr Gly Asp Lys Ala
            260                 265                 270         
Phe Glu Val Ala Thr Met Ala Ser Val Thr Ser Lys Arg Trp Pro Ile
        275                 280                 285             
Val Gly Val Arg Leu Val Ser Glu Phe Pro Tyr Ile Glu Ala Glu Leu
    290                 295                 300                 
Thr Asp Gly Ser Glu Ile Ser Leu Leu Pro Ser Asp Ser Asp Arg Tyr
305                 310                 315                 320 
Lys Lys Arg Phe Cys Lys Ser Asp Ala Asp Gln Lys Gly Phe Ile Thr
                325                 330                 335     
Ile Val Asp Val Pro Cys Val Leu Glu Ser Ile Asn Val Gln Met Asp
            340                 345                 350         
Glu Asn Thr Leu His Glu Ile Leu Asn Glu Val Asp Leu Asn Lys Asn
        355                 360                 365             
Gly Gln Val Glu Leu Asn Glu Phe Leu Gln Leu Met Ser Ala Ile Gln
    370                 375                 380                 
Lys Gly Arg Pro Cys His Leu Pro Pro Leu Thr Asp His Leu Cys Ser
385                 390                 395                 400 
Cys Val His Ser Gly Cys Val Phe Cys Arg Ala Phe Gln Ala Ile Arg
                405                 410                 415     
Pro Glu Ser Arg Ile Arg Lys Trp Met Gly Pro Gln Lys Thr Asn Ser
            420                 425                 430         
Val Val Phe Leu Cys Ser Phe Thr Gln Val Thr Leu Cys Gly Ile Trp
        435                 440                 445             
Leu Gly Thr Glu Pro Pro Phe Val Asn Lys Asp Pro Gln Phe Met Pro
    450                 455                 460                 
Gly Tyr Ile Ile Ile Gln Cys Asn Glu Gly Ser Val Thr Ala Phe Tyr
465                 470                 475                 480 
Ser Val Leu Gly Tyr Leu Gly Phe Leu Val Leu Gly Ser Leu Ala Val
                485                 490                 495     
Ala Phe Leu Ala Arg Asn Leu Pro Asp Ala Phe Asn Glu Ala Lys Phe
            500                 505                 510         
Leu Thr Phe Ser Met Leu Arg Glu Gln His His Cys Ser Cys Val Leu
        515                 520                 525             
Arg Arg Lys Phe Ser Gly Arg Asn Ile Gln Tyr Ile Gln Pro Ala Asp
    530                 535                 540                 
Gln Tyr Thr Lys Thr Leu Glu Glu Gly Gly Ala Val Thr Cys Pro Asn
545                 550                 555                 560 
Leu Gln Arg Lys Ala Met Lys Ser Gln Gly Asn Trp Glu Gly Pro Leu
                565                 570                 575     
Pro Trp Arg Leu Glu Ala His Ser Glu Asn Arg Val Glu Ser Ala Ser
            580                 585                 590         
Arg Pro His Leu Pro Gly His His Phe Gly Ala Ser Ile Phe Gly Leu
        595                 600                 605             
Gly Asn Glu Thr Gln Ser Ala Ser Arg Glu Gln Pro Gln Pro Pro Arg
    610                 615                 620                 
Arg Arg His Ala Thr Pro Pro Gly Gly Glu Ala Gly Gly Asp Pro Leu
625                 630                 635                 640 
Cys Arg Tyr Arg Gly Lys Arg Ser Leu Pro Ser Val Leu Ser Thr Phe
                645                 650                 655     
Ser Gly Asp Val Gly Glu Ala Arg Glu Glu Pro Leu Cys Ser Tyr Gln
            660                 665                 670         
Gly Lys Arg Ser Leu Pro Ser Val Leu Ser Thr Phe Ser Gly Asp Val
        675                 680                 685             
Gly Glu Ala Arg Glu Glu Pro Leu Cys Ser Tyr Gln Gly Lys Arg Asn
    690                 695                 700                 
Leu Pro Ser Val Leu Ser Thr Phe Ser Gly Asp Val Gly Glu Ala Arg
705                 710                 715                 720 
Glu Glu Pro Leu Cys Ser Tyr Gln Gly Lys Arg Asn Leu Pro Ser Val
                725                 730                 735     
Leu Ser Thr Phe Ser Gly Asn Arg Gly Glu Ala Gly Gly Asp Pro Leu
            740                 745                 750         
Cys Arg Tyr Arg Gly Lys Arg Ser Leu Pro Ser Val Leu Ser Thr Phe
        755                 760                 765             
Ser Gly Asp Val Gly Glu Ala Arg Glu Glu Pro Leu Cys Ser Tyr Gln
    770                 775                 780                 
Gly Lys Arg Asn Leu Pro Ser Val Leu Ser Thr Phe Ser Gly Asp Val
785                 790                 795                 800 
Gly Glu Ala Arg Glu Glu Pro Leu Cys Ser Tyr Gln Gly Lys Arg Asn
                805                 810                 815     
Leu Pro Ser Val Leu Ser Thr Phe Ser Gly Asn Arg Gly Glu Ala Gly
            820                 825                 830         
Gly Asp Pro Leu Cys Arg Tyr Arg Gly Lys Arg Ser Leu Pro Ser Val
        835                 840                 845             
Leu Ser Thr Phe Ser Gly Asp Val Gly Glu Ala Arg Glu Glu Pro Leu
    850                 855                 860                 
Cys Ser Tyr Gln Gly Lys Arg Asn Leu Pro Ser Val Leu Ser Thr Phe
865                 870                 875                 880 
Ser Gly Asp Ala Gly Glu Ala Arg Gly Thr Leu Phe Ala Ala Ile Glu
                885                 890                 895     
Gly Arg Glu Thr Ser His Leu Ser Phe Val Leu Ser Leu Arg Thr Leu
            900                 905                 910         
Asp Pro Ser Leu Asp Gln Ala Thr Val Ile Ser Ile Arg Thr Phe Leu
        915                 920                 925             
Lys Val Ala Gln Pro Ser Glu Ser Pro Ala Thr Ser Asn Arg Leu Gly
    930                 935                 940                 
Pro Tyr Glu Arg Pro Leu Glu Arg Thr Arg Asp Ser Gly Arg Glu Arg
945                 950                 955                 960 
Gly Arg Met Ser Asp Ser Ile Ser Lys Glu Pro Leu Gly Leu Cys
                965                 970                 975 


<210> 2903
<211> 121
<212> PRT
<213> Homo sapiens

<400> 2903
Met Tyr Leu Ala Ser Arg Ser Met Gly Leu Ala Arg Pro Ser Arg Met
 1               5                  10                  15      
Arg Ile Leu Glu Arg Ser Leu Ala Cys Trp Arg Trp Lys Leu Ser Ser
            20                  25                  30          
Cys Ser Ser His Val Leu Lys Cys Ser Ala Ser Phe Ser Arg Cys Ser
        35                  40                  45              
Ile Ser Ser Ser Cys Ser Arg Met Ala Phe Ser Arg Ser Arg Ser Ser
    50                  55                  60                  
Arg Ser Cys Phe Thr Phe Cys Ser Ser Ser Arg Leu Ser Ser Trp Ile
65                  70                  75                  80  
Leu Leu Phe Arg Ser Phe Ser Ser Phe Ser Ser Arg Trp Leu Ile Pro
                85                  90                  95      
Phe Phe Ser Arg Ala Leu Phe Gln Met Lys Val Pro Ser Arg Leu Leu
            100                 105                 110         
Ser Pro Lys Gly Leu Ser Val Leu Val
        115                 120     


<210> 2904
<211> 495
<212> PRT
<213> Homo sapiens

<400> 2904
Met Ala Gly Ile Gln Ala Glu Thr Leu Arg Glu Ala Cys Glu Phe Pro
 1               5                  10                  15      
Ser Ala Ser Ala Pro Leu Thr Leu His Phe Thr Asn Ser Gln Ser His
            20                  25                  30          
Gln Phe Leu Leu Thr Asn Ala Leu Ala Pro Pro Pro Ala Asp Ser Val
        35                  40                  45              
Gln Asp Ser Pro Lys Ser Ser Val Val Arg Ala Ser Ser Thr Cys Arg
    50                  55                  60                  
Trp Pro Gln Pro Arg Arg Tyr Thr Thr Gln Ala Phe Gly Ser Ser Phe
65                  70                  75                  80  
Gly Ala Asp Thr Thr Leu Ser Lys Glu Leu Lys Asp Ser Gly Ala Lys
                85                  90                  95      
Lys Lys Ser Leu Gln Glu Thr Asp Lys His Trp Gln Trp Leu Thr Trp
            100                 105                 110         
Arg Thr Leu Glu Ile Phe Thr Met Lys Gly Ser Arg Arg Pro Arg Ser
        115                 120                 125             
Pro Ser Asp Ser Cys Thr Glu Ser Lys Ser Asp His Ala Gly Glu Ser
    130                 135                 140                 
Gly Glu Ala Gln Val Asp Gly Leu Gln Leu His Ala Ile Lys Cys Pro
145                 150                 155                 160 
Lys Thr Pro Glu Ser Gly Gly Ala Gly Ser Ser Ser Arg Cys Arg Thr
                165                 170                 175     
Ser Ser Gly Thr Ala Ser Ser Thr Pro Pro Cys Thr Ala Ala Pro Gly
            180                 185                 190         
Ala Ala Pro Gly Pro Gln Leu Pro Gln Arg Lys Met Ile Ile Ala Ile
        195                 200                 205             
Leu Glu Pro Gly Met Val Leu His Leu Arg Leu Gly Gln Glu Phe Leu
    210                 215                 220                 
Gly Leu Asp Pro Gln Gly Ala Leu Arg Leu Ser Leu Leu Asn Val Gln
225                 230                 235                 240 
Leu Leu Val Val Pro Glu Gln Leu Leu Met Ser Leu Lys Asp Leu Leu
                245                 250                 255     
Tyr Pro Ala His Ala Arg Trp Leu Leu Leu Thr Ser Thr Glu Thr Val
            260                 265                 270         
Trp Glu Ile Asp Ile Glu Asn Gly Ser Val Arg Ala Gln Arg Ala Glu
        275                 280                 285             
Asn Val Cys Val Ala Pro Ser Val Lys Glu Asp Leu Tyr Leu His His
    290                 295                 300                 
Pro Val Arg Ser Pro Glu Phe Ala Thr Ser Phe Tyr Gly Gly Gln Arg
305                 310                 315                 320 
Ala Arg Pro Glu Asp Val Ser Ser Lys Ala His Gly Pro Cys Thr Leu
                325                 330                 335     
Arg His Gln Thr Gly Ile Arg Asp Ala Leu Phe Arg Met Lys His Thr
            340                 345                 350         
Cys Phe Phe Met Val Ser Pro Cys Thr His Val Ser Ala Ser Arg Arg
        355                 360                 365             
Arg Glu Met Leu Arg Met Leu Glu Arg Asn Ser Gln Ser His Gln Phe
    370                 375                 380                 
Leu Leu Thr Asn Pro Leu Ala Pro Pro Pro Ala Asp Ser Val Gln Asp
385                 390                 395                 400 
Ser Pro Lys Ser Ser Val Val Gly Ala Ser Ser Thr Cys Arg Trp Pro
                405                 410                 415     
Gln Pro Arg Arg Tyr Thr Thr Gln Ala Phe Gly Ser Ser Phe Gly Ala
            420                 425                 430         
Asp Thr Thr Leu Ser Lys Glu Leu Lys Asp Ser Gly Ala Lys Lys Lys
        435                 440                 445             
Ser Leu Gln Glu Thr Asp Lys His Trp Gln Trp Leu Thr Trp Arg Thr
    450                 455                 460                 
Leu Glu Ile Phe Thr Met Lys Gly Ser Arg Arg Pro Arg Ser Pro Ser
465                 470                 475                 480 
Asp Ser Cys Thr Glu Ser Lys Ser Asp His Ala Gly Glu Ser Gly
                485                 490                 495 


<210> 2905
<211> 113
<212> PRT
<213> Homo sapiens

<400> 2905
Met Ala Ser Ala Thr Arg Leu Ile Gln Arg Leu Arg Asn Trp Ala Ser
 1               5                  10                  15      
Gly His Asp Leu Gln Gly Lys Leu Gln Leu Arg Tyr Gln Glu Ile Ser
            20                  25                  30          
Lys Arg Thr Gln Pro Pro Pro Lys Leu Pro Val Gly Pro Ser His Lys
        35                  40                  45              
Leu Ser Asn Asn Tyr Tyr Cys Thr Arg Asp Gly Arg Arg Glu Ser Val
    50                  55                  60                  
Pro Pro Ser Ile Ile Met Ser Ser Gln Lys Ala Leu Val Ser Gly Lys
65                  70                  75                  80  
Pro Ala Glu Ser Ser Ala Val Ala Ala Thr Glu Lys Lys Ala Val Thr
                85                  90                  95      
Pro Ala Pro Pro Ile Lys Arg Trp Glu Leu Ser Ser Asp Gln Pro Tyr
            100                 105                 110         
Leu
    


<210> 2906
<211> 104
<212> PRT
<213> Homo sapiens

<400> 2906
Met Gly Pro Leu Leu Thr Ser Ser Ile His Arg His Asp Phe Phe Lys
 1               5                  10                  15      
Gly Val Asp Arg Phe Ala Ser Thr Ala Ala Arg Ser Ser Leu Ala Ala
            20                  25                  30          
Glu Asn Gln Lys Tyr Ser Pro Phe Thr Ser Thr Gly Ser Leu Tyr Leu
        35                  40                  45              
Thr Asn Ala Ala Ala Arg Asn Val Ser Thr Ala Leu Pro Arg His Leu
    50                  55                  60                  
Tyr Pro His Ser Gln Leu Leu Pro Gln Ser Asp Glu Thr Leu Leu Phe
65                  70                  75                  80  
Val Arg Lys Gly Pro Lys Ile Asn Pro Thr Ala His Val Gly Asp Gly
                85                  90                  95      
Thr Glu Glu Glu Val Lys Lys Asp
            100                 


<210> 2907
<211> 336
<212> PRT
<213> Homo sapiens

<400> 2907
Met Gly Asn Gln Leu Cys Ser Ala Thr Cys Thr Asp Met Pro Tyr His
 1               5                  10                  15      
Lys Arg Asp Leu Thr Trp Ala Cys Pro His Pro Leu Pro Asn Pro Pro
            20                  25                  30          
Leu Gly Leu Arg Ser Gly Cys Ser Pro Gly Pro Lys Pro Met Pro Ser
        35                  40                  45              
Phe Pro Gly Gln Ala Ser Gln Lys Leu Ala Ala Asn Leu Ala Thr Ser
    50                  55                  60                  
Ala Val Ile Thr Asn His Val Gln Asp His Leu Thr Trp Pro Met Ala
65                  70                  75                  80  
Arg Tyr Phe Gln Met Val Val Glu Leu His Ser Pro Ser Cys Ser Arg
                85                  90                  95      
Asp Pro Tyr Phe Cys Ser Val Ser Thr Val Ser Asp Gly His Ser Ala
            100                 105                 110         
Arg Trp Gln Ala Met Leu Ser Phe Phe Pro Gly Glu Glu Thr Met His
        115                 120                 125             
Pro Leu Leu Val Ser Ser Tyr Val Cys Leu Val Leu Leu Thr Val Cys
    130                 135                 140                 
Thr Ile Arg Glu Ser Ser Ala Cys Cys Ser Gln Thr Ser His Ala Asn
145                 150                 155                 160 
Glu Asp Leu Asp Arg Met Tyr Leu Ala Gly Ala Ser Gly Arg Glu Gly
                165                 170                 175     
Val Thr Gly Tyr Ile Glu Leu Leu Leu Arg His Leu Cys Ile Gln Ala
            180                 185                 190         
Arg Glu Lys Thr Glu Arg Leu Pro Ala Arg Gly Asp Arg Phe Pro Pro
        195                 200                 205             
Gly Leu Glu Arg Ser Gly Gln Ala Ala Ala Leu Glu Gly Arg Pro Lys
    210                 215                 220                 
Gln Gly Arg Gln Ala Leu Met Thr Asp Ile Cys Val Asp Asn Cys Ile
225                 230                 235                 240 
Cys Ser Ile Gln Arg Pro Phe Trp Ala Ser Gln Gln Leu Ser Glu Gln
                245                 250                 255     
Ser Ser Glu Asp Glu Val Gly Val Gly Gly Ser Met Phe Pro Leu Asp
            260                 265                 270         
Ser Pro Gly Phe Ser Pro Gln Cys Ser Asp Val Leu Gly Ala Ser Ser
        275                 280                 285             
Val Leu Lys Asn Leu Leu Leu His Ala Lys His Ser Glu Thr His Phe
    290                 295                 300                 
Cys Cys Ser Phe Pro Ala Arg Ser Phe Arg Arg Pro Leu Pro Ile Ala
305                 310                 315                 320 
Leu Leu Gln Gly Ala Leu Gln Ser Arg Ile Glu Asp Thr Lys Ser Val
                325                 330                 335     


<210> 2908
<211> 53
<212> PRT
<213> Homo sapiens

<400> 2908
Met Lys Thr Cys Ala Ser Gln Gln Glu Gly Phe Leu Glu Glu Val Met
 1               5                  10                  15      
Pro Lys Arg Lys Ala His Val Trp Leu Leu Glu Ser Ala Tyr Phe Arg
            20                  25                  30          
Glu Ala Ala Asn Pro Thr Leu Thr Ser Lys Gly Asn Leu Lys Asn Thr
        35                  40                  45              
Trp Ser Lys Asn Cys
    50              


<210> 2909
<211> 1579
<212> PRT
<213> Homo sapiens

<400> 2909
Met Asp Gln Asp Cys Ser Gly Cys Ile Lys Ser Arg Pro Ala Leu Lys
 1               5                  10                  15      
Ser Gly Phe Asp Asn Ser Ser Leu Ser Gly Glu Glu Arg Leu Lys Cys
            20                  25                  30          
Lys Leu Gly Lys Ser Phe Leu Leu Glu Lys Ser Leu Gly Lys Gly Met
        35                  40                  45              
Leu Ile His Cys Ser Leu Gly Val Ser Met Gly Lys Gly Lys Pro Pro
    50                  55                  60                  
Ser Pro Leu Thr Leu Thr Ser Phe Pro Pro Phe Cys Asp Leu Ala Lys
65                  70                  75                  80  
Ser Ala Phe His Val Val Leu Thr Thr Thr Gly Val Lys Leu Thr Met
                85                  90                  95      
Ile Pro Tyr Ser Arg Ser Arg Leu Met Ser Ser Glu Asp Leu Ala Glu
            100                 105                 110         
Ile Pro Gln Leu Gln Lys Leu Ser Ile Pro His Gly Phe Gln Asn Lys
        115                 120                 125             
Glu Ala Ala Ser Ser Pro Thr Pro Ser Ile Thr Leu Ser Gln Val Pro
    130                 135                 140                 
Asp Leu Gln Pro Gly Ser Gln Leu Phe Thr Glu Ile His Leu Ala Lys
145                 150                 155                 160 
Ile Glu Lys Met Phe Glu Glu Asp Ile Asn Ser Thr Gly Ala Leu Gly
                165                 170                 175     
Met Asp Ala Phe Ile Lys Ala Met Lys Lys Val Leu Ser Ser Val Ser
            180                 185                 190         
Asp Glu Met Leu Lys Glu Leu Phe Leu Lys Val Asp Ser Asp Cys Glu
        195                 200                 205             
Gly Phe Val Thr Trp Gln Lys Tyr Val Asp Tyr Met Met Arg Glu Phe
    210                 215                 220                 
Gln Gly Lys Glu Asp Met Arg Lys Ser Gln Tyr Arg Leu His Phe Tyr
225                 230                 235                 240 
Leu Pro Met Thr Val Val Pro Leu Asn His Gly Cys Glu Val Val Lys
                245                 250                 255     
Val Val Phe Leu Ile His Arg Phe Lys Lys Ile Gly Cys Phe Leu Thr
            260                 265                 270         
Val Thr Lys Asp Gly Ile Leu Gln Phe Trp Ser Glu Ser Phe Ser Leu
        275                 280                 285             
Met Ser Ser Phe Arg Leu Asn Gln Thr Gln Gln Leu Tyr Asn Gln Pro
    290                 295                 300                 
Met Trp Val Ile Asp Met Val Cys Leu His Asn Met Asn Leu Val Ala
305                 310                 315                 320 
Val Ala Ser Thr Arg Gln Lys Ile Asp Phe Phe Asp Ile Ser Asp His
                325                 330                 335     
Lys Cys Val Arg Ala Phe Thr Phe Val Asp Leu Asp Ser Cys Ala Leu
            340                 345                 350         
Val Met Asp Tyr Trp Ser Asp Tyr His Arg Gly Val Phe Cys Tyr Gly
        355                 360                 365             
Asp Ala Lys Gly Asn Val Ile Val Phe Thr Ser Glu Asn Met Thr Ser
    370                 375                 380                 
Gly Leu Phe Asn Pro Arg Ile Leu Pro Arg Ala Ser Lys Trp Asp His
385                 390                 395                 400 
Trp Ile Lys Val Ser Leu Gln Lys Leu Leu Asn Glu Lys Ser Ala Leu
                405                 410                 415     
His Arg Ser Tyr Arg Leu Lys Ala Leu His Pro Asn Trp Cys Glu Gln
            420                 425                 430         
Val Lys Phe Ile Pro Gln Met Asn Val Val Val Ser Cys Ser Ala Ile
        435                 440                 445             
Glu Lys Ser Ser Leu Val Leu Thr Ile Leu Pro Ala Lys Ala Ser Lys
    450                 455                 460                 
Lys Pro Arg Leu Ser Val Leu Arg Leu Arg Lys Gly Ile Leu Cys Phe
465                 470                 475                 480 
Asp Tyr Cys Pro Asp Arg Asn Phe Leu Val Thr Gly Gly Tyr Asp Ala
                485                 490                 495     
Phe Ile Arg Leu Trp Asn Pro Phe Val Ser Lys Arg Pro Val Trp Leu
            500                 505                 510         
Met Lys Gly His Gln Thr Ser Val Thr His Ile Leu Val Asp Ser Arg
        515                 520                 525             
Asn Asn Ser Ile Leu Ile Ser Val Ser Lys Asp Lys Asn Ile Arg Val
    530                 535                 540                 
Trp Asp Met Leu Asp Tyr Ile Cys Leu Gln Ser Phe Cys Gly Lys Phe
545                 550                 555                 560 
Phe Ala Leu Gly Asn Cys Pro Ile Thr Ser Ala Tyr Phe Phe Glu Lys
                565                 570                 575     
Asp Asn Thr Leu Ile Cys Ser Thr Tyr Ser Ile Gly Ile Leu Lys Gly
            580                 585                 590         
Tyr Leu Glu Ala Gln Gly Leu Ile Lys Ala Arg Lys Arg Thr Thr His
        595                 600                 605             
Cys Ser Pro Leu Cys Ala Val Leu Tyr Ser Lys Ile Phe Lys Gln Val
    610                 615                 620                 
Val Ser Gly Cys Leu Arg Gly Thr Val Ser Val Trp Glu Val Val Thr
625                 630                 635                 640 
Gly Arg Lys Thr Met Glu Phe Ala Val Ser Gly Gly Gln His Val Glu
                645                 650                 655     
Met Thr Ala Met Ala Leu Asp Glu Ser Glu Arg Cys Leu Leu Thr Gly
            660                 665                 670         
Leu Arg Asp Gly Thr Met Lys Met Trp Asn Tyr Asn Ile Gly Lys Cys
        675                 680                 685             
Leu Leu Thr Phe Pro Ser Pro Glu Gln Leu Glu Ile Ser Gly Ile Ile
    690                 695                 700                 
His Met Asn Lys Val Phe Tyr Val Thr Gly Trp Ser Lys Arg Ile Thr
705                 710                 715                 720 
His Phe Leu Phe His Lys Thr Lys Pro Val Leu Leu Cys Tyr His Trp
                725                 730                 735     
Gln Thr Tyr His Thr Glu Asp Ile Leu Ser Met Ala Lys Tyr Arg Asn
            740                 745                 750         
Gln Phe Leu Gly Thr Ser Ser Tyr Ser Gly Asp Ile Leu Phe Trp Asn
        755                 760                 765             
Thr Gly Thr Leu Lys Pro Ile Phe Asn Phe Asn Ala Ser Arg Ser Pro
    770                 775                 780                 
Ser Pro Leu Gln Pro Lys Arg Val Gln Asp Val Asn Asn Cys Leu Ala
785                 790                 795                 800 
Glu Ser His Arg Pro Ser Arg Pro Tyr Val Glu Arg Glu Lys Trp Thr
                805                 810                 815     
Tyr Lys Thr Ser Arg Lys Leu Ser Ser Leu Ser Pro Glu Ser Val Ala
            820                 825                 830         
Asn Thr Asn Leu Arg Arg Ser Leu Val Ser Ala Pro Pro Val Met Arg
        835                 840                 845             
Cys Pro Arg Asp Lys Glu Pro Asp Arg Pro Val Pro Gln Gln Lys Pro
    850                 855                 860                 
Ser Ser Ala Ser Gly Thr Ser Arg Gln Ser Ser Lys Ile His Ser Lys
865                 870                 875                 880 
Gln Ser Ile Tyr Lys Glu Asp Glu Thr Arg Lys Gly Glu Trp Gln Lys
                885                 890                 895     
Asn Met Leu Val Gln Ser Ser Ala Ser Val Glu Lys Ile Ile Phe Leu
            900                 905                 910         
Gln Thr Arg Pro Arg Leu Pro His Thr Ala Ala Leu Leu Ser Ser Cys
        915                 920                 925             
Met Asp Gly Tyr Ile Tyr Ala Trp Ser Leu His Glu Asn Gly Gly Leu
    930                 935                 940                 
Leu Gly Lys Phe Pro Val Asp Leu Asp Asn Gly Asp Val Val Val Gly
945                 950                 955                 960 
Ala Met Ala Thr Asp Lys Asn Asp Trp Ile Leu Ile Thr Gly Asp Cys
                965                 970                 975     
Lys Gly Tyr Ile Lys Ile Trp Asp Ile Lys Asp Tyr Cys Ala Leu Ile
            980                 985                 990         
Asp Lys Gln Pro Phe Gln Ser Ser Gly Ala Lys Val Val Ser Glu Ala
        995                 1000                1005            
His Asn Lys Phe Arg Leu Leu Ile Pro Gln Gln Leu Gly Thr Asn Phe
    1010                1015                1020                
Pro His Tyr Ile Pro Leu Glu Asp Lys Glu Val Val Ala Gly His Thr
1025                1030                1035                1040
Ile Ser Leu Val Pro Pro Thr Leu Leu Met Thr Trp Lys Gly His Leu
                1045                1050                1055    
Asn Ser Val Ala Asp Ile Leu Tyr Val Asp Asn Phe Gln Leu Val Ile
            1060                1065                1070        
Ser Ala Gly Gln Asp Arg Asp Val Lys Ala Trp Lys Leu Ser Gly Asp
        1075                1080                1085            
Ala Ile Val Gly Gly His Leu Val Lys Glu Ser Pro His Thr Arg Glu
    1090                1095                1100                
Gln Arg Asp Leu Ala Glu Ala Leu Ile Tyr Gln Arg Arg Glu Gln Ala
1105                1110                1115                1120
Ala Leu Met Ala Leu Leu His Gly Lys Ala Asp Lys Glu Ala Asp Thr
                1125                1130                1135    
Trp Ala Lys Leu Gln Lys Met Ala Leu Met Ser Pro Trp Ala Gly Glu
            1140                1145                1150        
Arg Pro Leu Glu Asp Ile Glu Asp Ser Trp Asn Lys Trp Glu Ser Arg
        1155                1160                1165            
Asp Lys Gln Val Ser Lys Val Leu Gly Ala Ala Tyr Lys Pro Lys Glu
    1170                1175                1180                
Arg Leu Gln Asn Thr Arg Phe Leu Ser Thr Arg Val Pro Tyr Gly Trp
1185                1190                1195                1200
Met Lys His Gln Pro Phe Ser Glu Gly Gly Gln Glu Pro Leu Ser Phe
                1205                1210                1215    
Asn Arg Ile Leu Gly His Gly Gln Val Trp Asp Glu Thr Asn Val Ala
            1220                1225                1230        
Ser Leu Phe Ala Lys Ala Leu Ala Glu Gly Gly Cys Met Gly Pro Gln
        1235                1240                1245            
Ala Thr Val Val Ser Gly Ser His Ser Pro Leu Asp Thr Arg Leu Leu
    1250                1255                1260                
Gly Met Gly Arg Pro Gln Gly Ala Ser Phe Leu Ser Pro Ser Cys Cys
1265                1270                1275                1280
Gly Pro Ser Gln Pro Pro Gln Pro Ile Pro Pro Pro Arg Ser His Pro
                1285                1290                1295    
Arg Cys Pro Ser Pro Pro Cys Arg Asp Pro Glu Asp Val Ala Leu Pro
            1300                1305                1310        
Pro Ala Thr Pro Leu Gly Leu Ser Gly Glu Val His Leu Ser Pro Asn
        1315                1320                1325            
Leu Val Phe Ser Leu Ala Pro His Arg Ala Leu Gly Gln Lys Ile Asn
    1330                1335                1340                
Val Leu Ser Cys Gly His Pro Gln Pro Pro Gly His Ala Cys Pro Asn
1345                1350                1355                1360
Pro Gly Leu Gln Lys His Leu Gly Ala Ala Val Leu Pro Gly Gly Ser
                1365                1370                1375    
Ala Leu Asp Val Lys Glu His Ser His Cys Thr Thr Ala Trp Ser Ser
            1380                1385                1390        
Asp Ser Gly Pro Ala Thr Ala Pro Arg Ile Cys Ala Leu Pro Gly His
        1395                1400                1405            
Phe Gln Ala Phe Leu Leu Ala Val Phe Phe Val Leu Ile Asn Val Pro
    1410                1415                1420                
Pro Gln Ile Pro Pro Cys Thr Gln Glu Leu Val Ile Leu His Ala Ala
1425                1430                1435                1440
Ile Thr Ala Gln Pro Pro Thr Pro His Ser Ser Gly Ala His Thr Cys
                1445                1450                1455    
Cys Asn Leu Arg Leu Leu Asp Phe Gly Trp Gly His Gly Ser Trp Pro
            1460                1465                1470        
Leu Ser Ser Thr Asp Lys Lys Leu Glu Glu Gly Ala Gly Gly Phe Glu
        1475                1480                1485            
Gly Arg Gly Met Leu Thr Ala Glu His Gly Lys Leu Arg Ala Glu Leu
    1490                1495                1500                
Arg Ala Glu Asp Ser His Arg Tyr Pro Thr Val Leu Ile Lys Leu Ala
1505                1510                1515                1520
Ser Ser Asp Leu Gly Ala Lys Ala Asp Leu Gly Thr Pro Met Val Leu
                1525                1530                1535    
Leu Glu Glu Gly Pro Trp Met Val Glu Met Cys Thr Leu Val Glu Leu
            1540                1545                1550        
Leu Leu Cys Gly Pro Asn Gly Ser Leu Pro Pro Ala Ala Arg Thr Gln
        1555                1560                1565            
Arg Gly Ser His Pro Gln Ser His Val Cys Gly
    1570                1575                


<210> 2910
<211> 164
<212> PRT
<213> Homo sapiens

<400> 2910
Met Gln Gly Arg Arg Cys Val Val Ser Phe Ser Arg Lys Ala Ala Gly
 1               5                  10                  15      
Pro Gly Leu Pro Arg Ala Ser Arg Glu Thr Trp Ala Thr Leu Ala Val
            20                  25                  30          
Leu Asp Ala Lys Pro Arg Ala His Lys Arg His Ser Ala Pro Asp Thr
        35                  40                  45              
Val Arg Arg Arg Pro Thr Gly Pro Ser Glu Gly Ala Ala Ala Ala Val
    50                  55                  60                  
Thr Leu Ala Ala Gly Cys Val Leu Arg His Leu Arg Ser Leu Cys Ala
65                  70                  75                  80  
Gly Pro Ser Val Gly Asn Thr Asp Pro Tyr Lys Ser Leu Gln His Gly
                85                  90                  95      
Pro Ile Pro Gln Ile Ala Glu Pro Gln His Arg Arg Asp Arg Asp Arg
            100                 105                 110         
Glu Gly Gln Thr Gln Gly Ala Gly Asp Pro Pro Pro Ser Glu Pro Ser
        115                 120                 125             
Pro Pro Ser Asp Pro Pro Pro Ser Asp Ser Leu Pro Ser Asp Pro Pro
    130                 135                 140                 
Pro Pro Ser Asp Leu Pro Leu Ser Ser Asp Ser Gln Leu Gly Ile Leu
145                 150                 155                 160 
Gly Gln Glu Asp
                


<210> 2911
<211> 150
<212> PRT
<213> Homo sapiens

<400> 2911
Met Trp Arg Gly Arg Ala Gly Ala Leu Leu Arg Val Trp Gly Phe Trp
 1               5                  10                  15      
Pro Thr Gly Val Pro Arg Arg Arg Pro Leu Ser Cys Asp Ala Ala Ser
            20                  25                  30          
Gln Ala Gly Ser Asn Tyr Pro Arg Cys Trp Asn Cys Gly Gly Pro Trp
        35                  40                  45              
Gly Pro Gly Arg Glu Asp Arg Phe Phe Cys Pro Gln Cys Arg Ala Leu
    50                  55                  60                  
Gln Ala Pro Asp Pro Thr Arg Asp Tyr Phe Ser Leu Met Asp Cys Asn
65                  70                  75                  80  
Arg Ser Phe Arg Val Asp Thr Ala Lys Leu Gln His Arg Tyr Gln Gln
                85                  90                  95      
Leu Gln Arg Leu Val His Pro Asp Phe Phe Ser Gln Arg Ser Gln Thr
            100                 105                 110         
Glu Lys Asp Phe Ser Glu Lys His Ser Thr Leu Val Asn Asp Ala Tyr
        115                 120                 125             
Lys Thr Leu Leu Ala Pro Leu Ser Arg Gly Leu Tyr Leu Leu Asn Arg
    130                 135                 140                 
Lys Asn Leu Leu Thr Met
145                 150 


<210> 2912
<211> 109
<212> PRT
<213> Homo sapiens

<400> 2912
Met Ser Glu Glu Thr Arg Arg Lys Val Val Ile Leu Gly Asp Asn Trp
 1               5                  10                  15      
Lys Gln Glu Leu Thr Lys Phe Ile Ser Pro Asp Gln Leu Pro Val Glu
            20                  25                  30          
Phe Gly Gly Thr Met Thr Asp Pro Asp Gly Asn Pro Lys Cys Leu Thr
        35                  40                  45              
Lys Ile Asn Tyr Gly Gly Glu Val Pro Lys Ser Tyr Tyr Leu Cys Lys
    50                  55                  60                  
Gln Val Arg Leu Gln Tyr Glu His Thr Arg Ser Val Gly Arg Gly Ser
65                  70                  75                  80  
Ser Leu Gln Val Glu Asn Glu Ile Leu Phe Pro Gly Cys Val Leu Arg
                85                  90                  95      
Cys Pro Glu Val Leu Gln His Leu Gln Pro Gly Ser Phe
            100                 105                 


<210> 2913
<211> 139
<212> PRT
<213> Homo sapiens

<400> 2913
Met Ile Ala Phe Leu Ala Phe Leu Leu Gly Pro Gly Gln Leu Pro Cys
 1               5                  10                  15      
Arg Pro Gln Pro Ser Val Ala Thr Pro Thr Ala Thr Glu Pro Thr Leu
            20                  25                  30          
Ala Phe Trp Thr Leu Val Lys Gln Ala Glu Gln Glu Ala Gly Ala Ala
        35                  40                  45              
Pro Val Lys Gly Met Arg Leu Val Pro Gly Ser His Ser Asn Ser Ser
    50                  55                  60                  
Ser Gly Ala Trp Ile Arg Gln Leu Tyr Ser Lys Gly Gln Leu Ser Ser
65                  70                  75                  80  
Pro Pro Ser Glu Gly Leu Gly Cys Glu Gly Pro Gly Gly Arg Gln Gly
                85                  90                  95      
Trp Gly Lys Asp Pro Gly Val Arg Thr Ser Pro Pro Phe Gly Leu Gln
            100                 105                 110         
Trp Gln Gln Ala His Leu Ala Val Ser Arg Ala Leu Arg Val Pro Ser
        115                 120                 125             
Asp Gly Ser Thr Phe His Ser Gln Ile Pro Ser
    130                 135                 


<210> 2914
<211> 179
<212> PRT
<213> Homo sapiens

<400> 2914
Met Ala Pro Gly Arg Pro Pro Val His Pro Ser Val Pro Leu Arg Pro
 1               5                  10                  15      
Gly Pro Ala Ser Cys Thr Ala Thr Ala Ala Ala Pro Pro Arg Thr Glu
            20                  25                  30          
Asp Arg Ser Ser Gly Gly Pro Ser Gly Ser Cys Gly Val Gly Ser Arg
        35                  40                  45              
Ala Leu Trp Cys Leu Gln Ser Pro Pro Gln Ala Pro Ile His Gly Gln
    50                  55                  60                  
Leu Gly Pro Lys Gly Glu Gly Val Thr Ser Gln Val Val Val Thr Gln
65                  70                  75                  80  
Glu His Ser Leu Ser Thr Thr Pro Gly Gly Ala Val Thr Phe Thr Tyr
                85                  90                  95      
Gly Ser Lys Ile Gly Ala Val Ile Arg Ala Ser Arg Gln Leu Gly Pro
            100                 105                 110         
Thr Glu His Leu Ala Met Ser Pro Gly Gln Trp Glu Glu Ser Thr Asn
        115                 120                 125             
Asn Ser His Leu Ser Pro Ala Glu Gly Ala Val Asp Leu Leu Arg Gly
    130                 135                 140                 
Ala Gln Pro Glu Asp Glu Ala Glu Tyr Thr Val Gly Tyr Thr Thr Val
145                 150                 155                 160 
Val Leu Ser Thr Val Arg Asp Pro Asp Gly Glu Ala Gly His Glu Arg
                165                 170                 175     
Ala Phe Gly
            


<210> 2915
<211> 424
<212> PRT
<213> Homo sapiens

<400> 2915
Met Asp Pro Ile Lys Gln Pro Ala Ser Ser Phe Asp Ile Thr Glu Ala
 1               5                  10                  15      
Ala Val Ser Phe Ala Lys Asp Ser Leu Ala Gly Gly Val Ala Ala Ala
            20                  25                  30          
Ile Ser Lys Met Ala Val Ala Pro Ile Glu Arg Val Lys Leu Leu Leu
        35                  40                  45              
Gln Val Gln His Ala Ser Lys Gln Ile Thr Ala Asp Lys Gln Tyr Lys
    50                  55                  60                  
Gly Ile Arg Asp Cys Met Val Cys Ile Pro Lys Glu His Gly Val Leu
65                  70                  75                  80  
Ser Trp Cys Asp Lys Tyr Lys Gln Ile Phe Leu Asp Gly Val Asp Lys
                85                  90                  95      
Arg Ser Gln Phe Trp Arg Tyr Phe Ala Gly Asn Leu Ala Ser Gly Gly
            100                 105                 110         
Ala Thr Gly Ala Thr Ser Leu Cys Phe Val Tyr Pro Leu Asp Phe Ala
        115                 120                 125             
His Thr Arg Val Ala Ala Asp Val Gly Lys Ala Gly Ala Glu Arg Glu
    130                 135                 140                 
Leu Arg Gly Phe Gly Asp Cys Leu Val Lys Ile Tyr Lys Ser Asp Gly
145                 150                 155                 160 
Ile Lys Ser Leu Tyr Gln Gly Phe Asn Val Ser Val Gln Gly Asn Ala
                165                 170                 175     
Ser Gly Ser Gln Glu His Ser His Cys His Gln Leu Asp Asp Ala Gln
            180                 185                 190         
Thr Val Thr Ala Val Ala Gly Leu Thr Ser Tyr Ser Phe Asn Thr Ile
        195                 200                 205             
Cys Cys Tyr Met Met Met Gln Ser Gly Cys Lys Gly Thr Asp Ile Met
    210                 215                 220                 
Tyr Thr Gly Thr Phe Asp Cys Trp Arg Lys Ile Thr His Asp Glu Gly
225                 230                 235                 240 
Ser Lys Ala Val Phe Lys Gly Ala Trp Ser Ser Val Leu Arg Gly Met
                245                 250                 255     
Gly Gly Ala Phe Val Leu Val Leu Tyr Asp Glu Thr Lys Lys Tyr Ile
            260                 265                 270         
Lys Leu Ser Gly Gly Arg Lys Asp Arg Arg Lys Thr Trp Ile Ser Ala
        275                 280                 285             
Phe Gly Asn Val Tyr Phe Asp Leu Pro Asp Asn Tyr Ile Gln Thr Asp
    290                 295                 300                 
Leu Ser Val Leu Ala Pro Ser Thr Ser Ser Ser Leu Ser Phe Asn Ala
305                 310                 315                 320 
Gly Trp Glu Lys Arg Lys Leu Arg Ala Lys Arg His Leu Val Arg Gly
                325                 330                 335     
Ser Arg Arg Arg Tyr Thr Pro Ser Thr Cys Pro His Pro Thr Lys Ser
            340                 345                 350         
Gln Ala Pro Lys Gly Ser His Ala Ala Thr Glu Gly Pro Arg Leu Leu
        355                 360                 365             
Thr Thr Ala Ala Arg Arg Ala Ser Pro Gln Ala Pro Phe Thr Val Arg
    370                 375                 380                 
Asp Glu Gly Ser Ala Ala Val Leu Gly Val Ala Leu Ile His Arg His
385                 390                 395                 400 
Leu Ala Ser Gly Leu Leu Pro Pro Arg Arg Trp Lys Gly Ala Gly Pro
                405                 410                 415     
Ala Pro Ser Cys Gly Ala Arg Phe
            420                 


<210> 2916
<211> 150
<212> PRT
<213> Homo sapiens

<400> 2916
Met Thr Leu Asp Ser Trp Leu Leu Ile Thr Arg Val Val Gly Glu Ser
 1               5                  10                  15      
Arg Arg Arg Gln Gln Ser Ser Leu Lys Lys Thr Ser Gly Leu Lys Lys
            20                  25                  30          
Leu Pro Thr Leu Val Leu Ala Ile Gly Asn Thr Val Tyr Lys Cys Thr
        35                  40                  45              
Leu Leu Gln Leu Val Leu Glu Asn Leu Gly Thr Asp Ala Ser Pro Gln
    50                  55                  60                  
Gly Asn Ile Arg Val Gly Asp Gln Ala Arg Val Ile Ala His Val Pro
65                  70                  75                  80  
Ser Pro Asn Lys Ala Ser Lys Pro Thr Thr Gln Thr Trp Val Gln Arg
                85                  90                  95      
Gln Thr Leu Pro Leu Thr Glu Arg Ser Ser Val Ser Leu Ser Gly Glu
            100                 105                 110         
Trp Glu Ser Ser Leu Thr Gly Ala Lys Thr Leu Ala Leu Gly Met Ile
        115                 120                 125             
Lys Phe Lys Ala Phe Leu Gly His Ser His Asn Gln Ser Leu Gln Ala
    130                 135                 140                 
Phe Thr Cys Thr Thr Ile
145                 150 


<210> 2917
<211> 329
<212> PRT
<213> Homo sapiens

<400> 2917
Met Arg Asn Glu Val Ala Glu Arg Glu Lys Ala Asp Ile Asn Val Thr
 1               5                  10                  15      
Leu Val Phe Gln Gly Tyr Glu Ser Thr Pro Ile Met Arg Arg Arg Gly
            20                  25                  30          
Lys Lys Pro Arg Gln Arg Gly Gln Lys Ser Gly Gly Arg Gly Lys Lys
        35                  40                  45              
Pro Arg Gly Arg Lys Ala Ala Lys Ser Ser Gly Gly Gly Gly Lys Lys
    50                  55                  60                  
Pro Glu Gln Gln Lys Ala Ser Ala Ala Gly Ala Glu Asn Arg Gly Gly
65                  70                  75                  80  
Gly Glu Gln Lys Ala Ala Ala Arg Glu Arg Gly Gln Lys Lys Asn Thr
                85                  90                  95      
Lys Ser Arg Asp Gly Gly Gly Gln Lys Pro Arg Arg Gln Lys Ala Val
            100                 105                 110         
Ala Thr Gly Ala Glu Ser Arg Gly Gly Gly Gly Lys Ser Arg Gly Asp
        115                 120                 125             
Lys Lys Pro Arg Gly Arg Gly Ala Lys Ser Arg Ser Gly Gly Asp Lys
    130                 135                 140                 
Lys Arg Arg Arg Arg Glu Ala Lys Ser Arg Val Gly Lys Thr Arg Gly
145                 150                 155                 160 
Gly Gly Arg Lys Lys His Arg Arg Pro Lys Pro Ala Ala Gly Gly Ala
                165                 170                 175     
Lys Thr Ala Val Ala Gly Ala Lys Ser Arg Lys Lys Pro Arg Arg Arg
            180                 185                 190         
Gly Pro Lys Ser Ala Ala Glu Lys Val Ala Gly Trp Gly Trp Gln Lys
        195                 200                 205             
Ala Ala Ala Ala Gly Ala Lys Ser Cys Lys Asn Leu Arg Arg Gln Arg
    210                 215                 220                 
Gln Lys Thr Val Ala Ser Gly Val Lys Ser His Ser Gly Lys Lys Arg
225                 230                 235                 240 
Arg Arg Arg Gly Gln Lys Ala Ala Ala Ala Gly Gln Lys Ala Gly Ala
                245                 250                 255     
Ala Lys Ser Leu Gly Gly Gly Asp Gln Lys Pro Arg Arg Trp Val Lys
            260                 265                 270         
Lys Pro Gln Arg Gln Lys Ala Val Ala Thr Gly Ala Asp Ser Cys Gly
        275                 280                 285             
Val Lys Leu Lys Ala Ser Glu Glu Met Pro Leu Ala Ser Phe Val Cys
    290                 295                 300                 
Ala Arg Ile Arg Gln Gly Lys Ala Ala Asp Ala Leu Val Ser Arg Phe
305                 310                 315                 320 
Leu Ala Ser Tyr Arg Glu Lys His Val
                325                 


<210> 2918
<211> 205
<212> PRT
<213> Homo sapiens

<400> 2918
Met Gly Lys Val Lys Val Gly Val Asn Gly Phe Gly Arg Ile Arg Arg
 1               5                  10                  15      
Leu Val Ser Arg Val Ala Phe Asn Ser Val Lys Val Asp Ile Val Ala
            20                  25                  30          
Ile Asn Asp Pro Phe Ile Asp Leu Asn Tyr Met Gly Gly Ala Lys Arg
        35                  40                  45              
Val Ile Ile Ser Ala Pro Ser Ala Asp Ala Pro Met Phe Val Met Gly
    50                  55                  60                  
Met Asn His Glu Lys Tyr Asp Asn Asn Leu Lys Ile Val Ser Asn Ala
65                  70                  75                  80  
Ser Cys Thr Thr Asn Tyr Leu Ala Pro Leu Ala Lys Val Ile His Asp
                85                  90                  95      
Asn Phe Gly Ile Val Glu Gly Leu Met Thr Thr Val His Ala Ile Thr
            100                 105                 110         
Ala Thr Gln Lys Thr Ala Asp Gly Pro Ser Gly Lys Leu Trp His Asp
        115                 120                 125             
Gly His Gly Ala Leu Gln Asn Ile Ile Pro Ala Ser Thr Asp Ala Ala
    130                 135                 140                 
Lys Ala Val Gly Lys Val Ile Pro Glu Leu Asn Gly Lys Leu Thr Gly
145                 150                 155                 160 
Met Ala Phe His Ala Pro Thr Ala Asn Val Ser Val Val Asp Leu Thr
                165                 170                 175     
Cys Cys Leu Glu Asn Pro Ala Lys Tyr Asp Asn Ile Lys Lys Val Val
            180                 185                 190         
Lys Gln Ala Leu Lys Ala Pro Leu Lys Gly Ile Leu Gly
        195                 200                 205 


<210> 2919
<211> 615
<212> PRT
<213> Homo sapiens

<400> 2919
Met Thr Ile Leu Pro Lys Lys Lys Pro Pro Pro Pro Asp Ala Asp Pro
 1               5                  10                  15      
Ala Asn Glu Pro Pro Pro Pro Gly Pro Met Pro Pro Ala Pro Arg Arg
            20                  25                  30          
Gly Gly Gly Val Gly Val Gly Gly Gly Gly Thr Gly Val Gly Gly Gly
        35                  40                  45              
Asp Arg Asp Arg Asp Ser Gly Val Val Gly Ala Arg Pro Arg Ala Ser
    50                  55                  60                  
Pro Pro Pro Gln Gly Pro Leu Pro Gly Pro Pro Gly Ala Leu His Arg
65                  70                  75                  80  
Trp Ala Leu Ala Val Pro Pro Gly Ala Val Ala Gly Pro Arg Pro Gln
                85                  90                  95      
Gln Ala Ser Pro Pro Pro Cys Gly Gly Pro Gly Gly Pro Gly Gly Gly
            100                 105                 110         
Pro Gly Asp Ala Leu Gly Ala Ala Ala Ala Gly Val Gly Ala Ala Gly
        115                 120                 125             
Val Val Val Gly Val Gly Gly Ala Val Gly Val Gly Gly Cys Cys Ser
    130                 135                 140                 
Gly Pro Gly His Ser Lys Arg Arg Arg Gln Ala Pro Gly Val Gly Ala
145                 150                 155                 160 
Val Gly Gly Gly Ser Pro Glu Arg Glu Glu Val Gly Ala Gly Tyr Asn
                165                 170                 175     
Ser Glu Asp Glu Tyr Glu Ala Ala Ala Ala Arg Ile Glu Ala Met Asp
            180                 185                 190         
Pro Ala Thr Val Glu Gln Gln Glu His Trp Phe Glu Lys Ala Leu Arg
        195                 200                 205             
Asp Lys Lys Gly Phe Ile Ile Lys Gln Met Lys Glu Asp Gly Ala Cys
    210                 215                 220                 
Leu Phe Arg Ala Val Ala Asp Gln Val Tyr Gly Asp Gln Asp Met His
225                 230                 235                 240 
Glu Val Val Arg Lys His Cys Met Asp Tyr Leu Met Lys Asn Ala Asp
                245                 250                 255     
Tyr Phe Ser Asn Tyr Val Thr Glu Asp Phe Thr Thr Tyr Ile Asn Arg
            260                 265                 270         
Lys Arg Lys Asn Asn Cys His Gly Asn His Ile Glu Met Gln Ala Met
        275                 280                 285             
Ala Glu Met Tyr Asn Arg Pro Val Glu Val Tyr Gln Tyr Ser Thr Glu
    290                 295                 300                 
Pro Ile Asn Thr Phe His Gly Ile His Gln Asn Glu Asp Glu Pro Ile
305                 310                 315                 320 
Arg Val Ser Tyr His Arg Asn Ile His Tyr Asn Ser Val Val Asn Pro
                325                 330                 335     
Asn Lys Ala Thr Ile Gly Val Gly Leu Gly Leu Pro Ser Phe Lys Pro
            340                 345                 350         
Gly Phe Ala Glu Gln Ser Leu Met Lys Asn Ala Ile Lys Thr Ser Glu
        355                 360                 365             
Glu Ser Trp Ile Glu Gln Gln Met Leu Glu Asp Lys Lys Arg Ala Thr
    370                 375                 380                 
Asp Trp Glu Ala Thr Asn Glu Ala Ile Glu Glu Gln Val Ala Arg Glu
385                 390                 395                 400 
Ser Tyr Leu Gln Trp Leu Arg Asp Gln Glu Lys Gln Ala Arg Gln Val
                405                 410                 415     
Arg Gly Pro Ser Gln Pro Arg Lys Ala Ser Ala Thr Cys Ser Ser Ala
            420                 425                 430         
Thr Ala Ala Ala Ser Ser Gly Leu Glu Glu Trp Thr Ser Arg Ser Pro
        435                 440                 445             
Arg Gln Arg Ser Ser Ala Ser Ser Pro Glu His Pro Glu Leu His Ala
    450                 455                 460                 
Glu Leu Gly Met Lys Pro Pro Ser Pro Gly Thr Val Leu Ala Leu Ala
465                 470                 475                 480 
Lys Pro Pro Ser Pro Cys Ala Pro Gly Thr Ser Ser Gln Phe Ser Ala
                485                 490                 495     
Gly Ala Asp Arg Ala Thr Ser Pro Leu Val Ser Leu Tyr Pro Ala Leu
            500                 505                 510         
Glu Cys Arg Ala Leu Ile Gln Gln Met Ser Pro Ser Ala Phe Gly Leu
        515                 520                 525             
Asn Asp Trp Glu Asp Arg Gln Glu Ala His Arg Asp Arg Pro Thr Gly
    530                 535                 540                 
Ser Gln Ala Ala Pro Glu Glu Arg Asp Ile Gln Thr Glu Glu Ser Leu
545                 550                 555                 560 
Pro Ala Pro His Ser Phe Gln Asp Glu Lys Asn Leu Pro Pro Pro Pro
                565                 570                 575     
Asp Thr Asp Ala Arg Glu Val Gly Gly Arg Ser Gly Lys Phe Pro Phe
            580                 585                 590         
Pro Val Pro Pro Arg Thr Ser Glu Pro Ser Met Leu Asn Phe Phe Phe
        595                 600                 605             
Ile Lys Ile Thr Phe Ile Leu
    610                 615 


<210> 2920
<211> 134
<212> PRT
<213> Homo sapiens

<400> 2920
Met Val Val Gly Gln Trp Ala Gly Ser Arg Ser Ser Arg Gly Arg Gly
 1               5                  10                  15      
Ser Phe Gly Met Gln Val Val Ser Val Gly Gly Pro Gly Lys Gly His
            20                  25                  30          
Gly Lys Glu Gln Thr Gly Arg Gly Ser Lys Gly His Lys Lys Gly Asn
        35                  40                  45              
Lys Gln Gly Ser Ser Asp Gly Val Ser Lys Ser Leu Glu Leu His Gln
    50                  55                  60                  
Gly Arg Ser Arg Ser Gln Val Asn Gly Asn Ser Gly Ala Leu Ile Lys
65                  70                  75                  80  
Glu Glu Lys Ser Asp His Arg Leu Pro Ala Pro Ser Gln Cys Ala Leu
                85                  90                  95      
Ser Arg Asp Ser Asn Glu Cys Asn Asn Gly Asn Arg Tyr Leu Pro Met
            100                 105                 110         
Asn Asn Arg Glu Lys Asn His Leu Gln Glu Gln Lys Leu Glu Thr Val
        115                 120                 125             
Ala Gln Arg Lys Glu Asp
    130                 


<210> 2921
<211> 142
<212> PRT
<213> Homo sapiens

<400> 2921
Met Ala Arg Thr Arg Trp Thr Ala Arg Lys Ser Thr Gly Gly Ile Ala
 1               5                  10                  15      
Pro Arg Lys Gln Leu Ala Thr Lys Ala Thr Cys Lys Ser Ala Pro Ser
            20                  25                  30          
Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala
        35                  40                  45              
Leu Arg Glu Ile Arg His Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg
    50                  55                  60                  
Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys
65                  70                  75                  80  
Thr Asp Leu Arg Phe Gln Arg Ala Ala Ile Gly Thr Leu Gln Glu Ala
                85                  90                  95      
Ser Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala
            100                 105                 110         
Ile His Ala Thr Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala
        115                 120                 125             
Arg His Ile Arg Gly Glu Arg Val Ser Glu Tyr Thr Met Met
    130                 135                 140         


<210> 2922
<211> 343
<212> PRT
<213> Homo sapiens

<400> 2922
Met Thr Thr Val Leu Thr Tyr Thr Phe Lys Lys Cys Thr Ser Asp Ala
 1               5                  10                  15      
Leu Leu Thr Ala Ser Glu Trp Ser Leu Arg Phe Ser Ile Arg Pro Leu
            20                  25                  30          
Ser Tyr Ser Ser Gln Ala Thr Leu Thr Gly Leu Leu His Gln Pro Ser
        35                  40                  45              
Val Pro Lys Glu Val Val Asp Tyr Ile Ile Phe Gly Thr Val Ile Gln
    50                  55                  60                  
Glu Val Lys Thr Ser His Val Ala Gly Glu Ala Ala Leu Gly Thr Ala
65                  70                  75                  80  
Phe Ser Asp Lys Thr Pro Ala His Thr Val Thr Met Ala Cys Ile Ser
                85                  90                  95      
Ala Asn Gln Ala Met Thr Thr Gly Val Gly Leu Ile Ala Ser Gly Gln
            100                 105                 110         
Cys Asp Val Ile Met Ala Gly Gly Val Glu Leu Met Phe His Val Pro
        115                 120                 125             
Ile Arg Gln Ser Arg Lys Met Arg Lys Leu Met Leu Asp Leu Thr Pro
    130                 135                 140                 
Glu Leu Pro Glu Val Ser Glu Phe Ser Thr Ser Glu Thr Thr Gly His
145                 150                 155                 160 
Ser Ala Asp Gln Leu Ala Val Ser Arg Leu Glu Gln Asp Glu Tyr Ala
                165                 170                 175     
Leu Arg Cys Pro Ser Leu Ala Lys Lys Ala Gln Asp Glu Gly Leu Leu
            180                 185                 190         
Ser Asp Val Val Pro Phe Lys Val Pro Gly Lys Asp Thr Val Thr Lys
        195                 200                 205             
His Asn Gly Ile Arg Pro Ser Ser Leu Glu Gln Met Ala Lys Leu Lys
    210                 215                 220                 
Pro Ala Phe Ile Lys Pro Tyr Gly Thr Ala Thr Ala Ala Asn Ser Ser
225                 230                 235                 240 
Phe Leu Thr Asp Gly Ala Ser Glu Ala Glu Glu Lys Ala Leu Ala Met
                245                 250                 255     
Gly Tyr Lys Pro Lys Glu Cys Leu Arg Asp Phe Met Tyr Phe Ala Gln
            260                 265                 270         
Asn Tyr Met Gly Arg Lys Ser Lys Val Thr Leu Leu Pro Ser Glu Lys
        275                 280                 285             
Phe Asn Asn Trp Gly Gly Ser Leu Ser Leu Glu His Pro Phe Gly Ala
    290                 295                 300                 
Thr Gly Cys Arg Leu Val Val Ala Ala Ala Asn Arg Leu Arg Lys Glu
305                 310                 315                 320 
Gly Gly Gln Tyr Ala Leu Ala Ala Ala Cys Ala Ala Gly Gly Gln Gly
                325                 330                 335     
His Gly His Ser Ile Ala Asn
            340             


<210> 2923
<211> 92
<212> PRT
<213> Homo sapiens

<400> 2923
Met Leu Leu Glu Ile Gln Val His Ile Thr His Thr Thr Val Gly Val
 1               5                  10                  15      
Met Lys Ile Pro Gly Asn Tyr Gly Thr Val Asp Val Thr Glu Pro Leu
            20                  25                  30          
Leu Lys Asn Met Phe Val Gly Ser Phe Pro Val Asp Phe Trp Lys Leu
        35                  40                  45              
Lys Tyr Ala Phe Val Leu Gln Leu Gly Leu Ser Asn Phe Ser Leu Leu
    50                  55                  60                  
Asp Thr Gly Glu Glu Phe Thr Lys Phe Trp Tyr Ile Asn Val Asp Tyr
65                  70                  75                  80  
Thr Asp Glu Val Glu Lys Arg Asn Val Ser Asp Phe
                85                  90          


<210> 2924
<211> 429
<212> PRT
<213> Homo sapiens

<400> 2924
Met Thr Tyr Ile Thr Asn Gln Ala Ala Val Tyr Phe Glu Lys Gly Asp
 1               5                  10                  15      
Tyr Asn Lys Cys Trp Glu Leu Cys Glu Lys Ser Ile Glu Val Gly Arg
            20                  25                  30          
Glu Asn Arg Glu Asp Tyr Leu Gln Ile Ala Lys Val Cys Ala Arg Ile
        35                  40                  45              
Gly Asn Ser Tyr Phe Lys Glu Glu Lys Tyr Lys Asp Ala Ile His Phe
    50                  55                  60                  
Tyr Asn Lys Ser Leu Ala Glu His Arg Thr Pro Asp Val Leu Lys Lys
65                  70                  75                  80  
Cys Gln Gln Ala Glu Lys Ile Leu Lys Glu Gln Glu Arg Leu Ala Tyr
                85                  90                  95      
Ile Asn Pro Asp Leu Ala Leu Glu Glu Lys Asn Lys Gly Asn Glu Cys
            100                 105                 110         
Phe Gln Lys Gly Asp Tyr Pro His Ala Met Lys His Tyr Thr Glu Ala
        115                 120                 125             
Ile Lys Arg Asn Pro Lys Asp Ala Lys Leu Tyr Ser Asn Arg Ala Ala
    130                 135                 140                 
Cys Tyr Thr Lys Leu Leu Asp Ser Ser Trp His Ser Arg Thr Val Lys
145                 150                 155                 160 
Asn Gly Tyr Thr Arg Lys Ala Val Ala Leu Glu Ala Met Lys Asp Tyr
                165                 170                 175     
Thr Lys Val Met Asp Val Tyr Arg Lys Ala Leu Asp Pro Asp Ser Ser
            180                 185                 190         
Cys Lys Glu Ala Ala Asp Gly Tyr Gln Arg Cys Met Met Ala Gln Tyr
        195                 200                 205             
Asn Arg His His Ser Pro Glu Asp Val Lys Arg Arg Ala Met Ala Asp
    210                 215                 220                 
Pro Glu Val Gln Gln Ile Met Ser Asp Ile Ala Met His Leu Ile Leu
225                 230                 235                 240 
Glu Gln Met Gln Lys Asp Pro Pro Gly Thr Gln Arg Thr Leu Lys Glu
                245                 250                 255     
Ser Cys Asn Arg Lys Glu Asp Pro Glu Ala Asp Gly Cys Gly Ser Asp
            260                 265                 270         
Cys Asn Ser Thr Met Thr Cys Pro Ser Pro Leu Pro Phe Ala Leu Met
        275                 280                 285             
Arg Lys Glu Glu Arg Gly Pro Arg Gln Ala Ala Arg Ser Gly Arg Glu
    290                 295                 300                 
Ser Arg Gly Arg Glu Gly Leu Thr Ser Leu Tyr Leu Tyr Pro Ser Arg
305                 310                 315                 320 
Leu Glu Asn Val Ala Ser Leu Gln Met Leu Glu Thr Leu Phe Ser Val
                325                 330                 335     
Phe Arg Asn Ala Thr Ala Ala Pro Phe Ser Thr Ile Pro Ile Ser Leu
            340                 345                 350         
Gly Phe Ser Asp Pro Leu Glu Leu Val Pro Gly Ala Gln Gly Leu Leu
        355                 360                 365             
Ser Val Pro Cys Tyr Gly Ser Tyr Ser Ile Ile Glu Ile Thr Ile Lys
    370                 375                 380                 
Glu Leu Leu Ala Val Cys Glu Ser Ser Gln Glu Arg Leu Arg Ile Leu
385                 390                 395                 400 
Tyr Thr Lys Ile Phe Asp Val Pro Glu Lys Met Pro Lys Asn Ala Thr
                405                 410                 415     
Tyr Arg Arg Pro Ile Phe Asp Asp Phe Arg Val Ala Lys
            420                 425                 


<210> 2925
<211> 170
<212> PRT
<213> Homo sapiens

<400> 2925
Met Ser Arg Glu Arg Leu Leu Ser Ser Pro Ser Ala Asp Arg Glu Thr
 1               5                  10                  15      
Glu Lys Ser Arg Gly Glu Leu Ala Ala Ala Ser Pro Ala Ser Pro Tyr
            20                  25                  30          
Thr Gly Ile Gly Pro Ser Ser Leu Ala Cys Leu Gly Thr Glu Lys Ala
        35                  40                  45              
Ala Ser Ala Pro Gly Ala Cys Pro Pro Pro Met Pro Gly Ala Phe Leu
    50                  55                  60                  
Gly Ile Arg Ser Thr Arg Arg Leu Ser Thr Arg Gly Gly Ala Ile Gly
65                  70                  75                  80  
Ala Ser Glu Ala Arg Lys Asp Ala Ser Gly Pro Glu Leu Pro Arg Pro
                85                  90                  95      
Pro Ala Gly Gln Gly Arg Gly Lys Leu Pro Ala Ala Arg Gly Gly Arg
            100                 105                 110         
Gly His Val Val Val Gly Ser Cys Arg Gly Val Pro Pro Glu Lys Thr
        115                 120                 125             
Val Leu Pro Val Ala Ala Lys Thr Glu Thr Gln Glu Val Ala Trp Arg
    130                 135                 140                 
Thr Gln Glu Asp His Gly Lys Lys Lys Ala Ala Asp His Met Ser Phe
145                 150                 155                 160 
Leu Lys Asp Phe Pro Leu Phe Phe Cys Ser
                165                 170 


<210> 2926
<211> 553
<212> PRT
<213> Homo sapiens

<400> 2926
Met Ala Ala Ser Lys Lys Ala Val Leu Gly Pro Leu Val Gly Ala Val
 1               5                  10                  15      
Asp Gln Gly Thr Ser Ser Thr Ser Phe Leu Val Phe Asn Ser Lys Thr
            20                  25                  30          
Ala Glu Leu Leu Ser His His Gln Val Glu Ile Lys Gln Glu Ser Pro
        35                  40                  45              
Arg Glu Gly Trp Val Glu Gln Asp Pro Lys Glu Ile Leu His Ser Val
    50                  55                  60                  
Tyr Glu Cys Ile Glu Lys Thr Cys Glu Lys Leu Gly Gln Leu Asn Ile
65                  70                  75                  80  
Asp Ile Ser Asn Ile Lys Ala Ile Gly Val Ser Asn Gln Arg Glu Thr
                85                  90                  95      
Thr Val Val Trp Asp Lys Ile Thr Gly Glu Pro Leu Tyr Asn Ala Val
            100                 105                 110         
Val Trp Leu Asp Leu Arg Thr Gln Ser Thr Val Glu Ser Leu Ser Lys
        115                 120                 125             
Arg Ile Pro Gly Asn Asn Asn Phe Val Lys Ser Lys Thr Gly Leu Pro
    130                 135                 140                 
Leu Ser Thr Tyr Phe Ser Ala Val Lys Leu Arg Trp Leu Leu Asp Asn
145                 150                 155                 160 
Val Arg Lys Val Gln Lys Ala Val Glu Glu Lys Arg Ala Leu Phe Gly
                165                 170                 175     
Thr Ile Asp Ser Trp Leu Ile Trp Asn Leu Thr Gly Gly Val Asn Gly
            180                 185                 190         
Gly Val His Cys Thr Asp Val Thr Asn Ala Ser Arg Thr Met Leu Phe
        195                 200                 205             
Asn Ile His Ser Leu Glu Trp Asp Lys Gln Leu Cys Glu Phe Phe Gly
    210                 215                 220                 
Ile Pro Met Glu Ile Leu Pro Asn Val Arg Ser Ser Ser Glu Ile Tyr
225                 230                 235                 240 
Gly Leu Met Lys Ala Gly Ala Leu Glu Gly Val Pro Ile Ser Gly Cys
                245                 250                 255     
Leu Gly Asp Gln Ser Ala Ala Leu Val Gly Gln Met Cys Phe Gln Ile
            260                 265                 270         
Gly Gln Ala Lys Asn Thr Tyr Gly Thr Gly Cys Phe Leu Leu Cys Asn
        275                 280                 285             
Thr Gly His Lys Cys Val Phe Ser Asp His Gly Leu Leu Thr Thr Val
    290                 295                 300                 
Ala Tyr Lys Leu Gly Arg Asp Lys Pro Val Tyr Tyr Ala Leu Glu Gly
305                 310                 315                 320 
Ser Val Ala Ile Ala Gly Ala Val Ile Arg Trp Leu Arg Asp Asn Leu
                325                 330                 335     
Gly Ile Ile Lys Thr Ser Glu Glu Ile Glu Lys Leu Ala Lys Glu Val
            340                 345                 350         
Gly Thr Ser Tyr Gly Cys Tyr Phe Val Pro Ala Phe Ser Gly Leu Tyr
        355                 360                 365             
Ala Pro Tyr Trp Glu Pro Ser Thr Arg Gly Ile Ile Cys Gly Leu Thr
    370                 375                 380                 
Gln Phe Thr Asn Lys Cys His Ile Ala Phe Ala Ala Leu Glu Ala Val
385                 390                 395                 400 
Cys Phe Gln Thr Arg Glu Ile Leu Asp Ala Met Asn Arg Asp Cys Gly
                405                 410                 415     
Ile Pro Leu Ser His Leu Gln Val Asp Gly Gly Met Thr Ser Asn Lys
            420                 425                 430         
Ile Leu Met Gln Leu Gln Ala Asp Ile Leu Tyr Ile Pro Val Val Lys
        435                 440                 445             
Pro Ser Met Pro Glu Thr Thr Ala Leu Gly Ala Ala Met Glu Ala Gly
    450                 455                 460                 
Ala Ala Glu Gly Val Gly Val Trp Ser Leu Glu Pro Glu Asp Leu Ser
465                 470                 475                 480 
Ala Val Thr Met Glu Arg Phe Glu Pro Gln Ile Asn Ala Glu Glu Ser
                485                 490                 495     
Glu Ile Arg Tyr Ser Thr Trp Lys Lys Ala Val Met Lys Ser Met Gly
            500                 505                 510         
Trp Val Thr Thr Gln Ser Pro Glu Ser Gly Asp Pro Ser Ile Phe Cys
        515                 520                 525             
Ser Leu Pro Leu Gly Phe Phe Ile Val Ser Ser Met Val Met Leu Ile
    530                 535                 540                 
Gly Ala Arg Tyr Ile Ser Gly Ile Pro
545                 550             


<210> 2927
<211> 91
<212> PRT
<213> Homo sapiens

<400> 2927
Met Leu Pro Glu His Pro Gln Met Asn Gln Ala Cys Asn Gln Arg Glu
 1               5                  10                  15      
Asn Val Ala Tyr Pro Val Phe Thr Ser Asp Thr His Ile His Pro Gln
            20                  25                  30          
Ala Met Arg Thr Phe Ser Leu Thr Phe Ser Ala Trp Ile Arg Gly Ser
        35                  40                  45              
Phe Leu Ile Ser Leu Pro Arg Gly Ala Val Ser Tyr Ser Ser Arg Asn
    50                  55                  60                  
Arg Gln Ser Asp Thr Arg Thr Arg Gly Asn Gly Gly Gly Cys Val Trp
65                  70                  75                  80  
Gly Leu Thr Arg His Leu Gly Leu Lys Thr Arg
                85                  90      


<210> 2928
<211> 125
<212> PRT
<213> Homo sapiens

<400> 2928
Met Lys Tyr Val Ile Phe Glu Ile Ser Tyr Thr Phe Glu Arg Leu Arg
 1               5                  10                  15      
Tyr Pro Tyr Glu Tyr Pro Leu Phe Ile Tyr Leu Ala Val Phe Leu Asp
            20                  25                  30          
Leu Pro Leu Leu Ala Thr Asp Arg Glu Lys Glu Val His Leu Ser Ser
        35                  40                  45              
Thr Glu Asp Gly Phe Leu Met Ser Ser Glu Tyr Gln Gly Ser Arg Lys
    50                  55                  60                  
Asp Leu Asn Gly Ser Val Thr Gly Cys Asp Ala Gly Leu Thr Asn Arg
65                  70                  75                  80  
Thr Leu Leu Pro Arg Ile Leu Asn Leu Glu Arg Val Pro Thr Lys Arg
                85                  90                  95      
Val Ser Ala Arg Leu Ala Met Asp Ser Ile Val Lys Gln Leu Cys Asp
            100                 105                 110         
Ser Asp Asn Asp Asn Gly Ser Ser Ile Ala Ala Val Ser
        115                 120                 125 


<210> 2929
<211> 208
<212> PRT
<213> Homo sapiens

<400> 2929
Met Ala Lys Gln Tyr Asp Val Leu Phe Arg Leu Leu Leu Ile Gly Asp
 1               5                  10                  15      
Ser Gly Val Gly Lys Thr Cys Leu Leu Cys Arg Phe Thr Asp Asn Glu
            20                  25                  30          
Phe His Ser Ser His Ile Ser Thr Ile Gly Val Asp Phe Lys Met Lys
        35                  40                  45              
Thr Ile Glu Val Asp Gly Ile Lys Val Arg Ile Gln Ile Trp Asp Thr
    50                  55                  60                  
Ala Gly Gln Glu Arg Tyr Gln Thr Ile Thr Lys Gln Tyr Tyr Arg Arg
65                  70                  75                  80  
Ala Gln Gly Ile Phe Leu Val Tyr Asp Ile Ser Ser Glu Arg Ser Tyr
                85                  90                  95      
Gln His Ile Met Lys Trp Val Ser Asp Val Asp Glu Val Gly Asp Ala
            100                 105                 110         
Thr Ser Leu Pro Gly Cys Gly Glu Gly Ala Ser Pro Gly Lys Ala Arg
        115                 120                 125             
Arg Gly Pro Asp Gly Lys Ala Asn Ala Ser Arg Lys Leu Cys Leu Pro
    130                 135                 140                 
Gln Pro Trp Met Lys Thr Ser Gly Thr His Gln Lys Ala Ser Arg Arg
145                 150                 155                 160 
Ser Leu Leu Gly Ile Arg Leu Met Arg Ser Arg Asn Gly Arg Trp Glu
                165                 170                 175     
Glu Ser Lys Gly Ser Ser Trp Arg Arg Ser Met Ala Trp Thr Ser Met
            180                 185                 190         
Lys Gln Val Pro Ala Pro Thr Ser Thr Leu Lys Ser His Ser Arg Val
        195                 200                 205             


<210> 2930
<211> 216
<212> PRT
<213> Homo sapiens

<400> 2930
Met Tyr Leu Val Thr Val Leu Arg Asn Leu Leu Ser Ile Leu Ala Val
 1               5                  10                  15      
Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn
            20                  25                  30          
Leu Cys Trp Ala Asp Ile Gly Tyr Thr Ser Ala Thr Val Pro Lys Met
        35                  40                  45              
Ile Val Asp Thr Gln Ser His Gly Arg Val Ile Ser His Ala Gly Cys
    50                  55                  60                  
Leu Thr Gln Met Ser Phe Leu Val Leu Phe Ala Cys Ile Glu Asp Met
65                  70                  75                  80  
Leu Leu Thr Val Met Ala Tyr Asp Cys Phe Val Ala Ile Cys Cys Pro
                85                  90                  95      
Leu His Tyr Pro Val Ile Val Asn Pro His Leu Cys Val Phe Phe Val
            100                 105                 110         
Leu Val Ser Phe Phe Leu Ser Leu Leu Asp Ser Gln Leu His Ser Trp
        115                 120                 125             
Ile Val Leu Gln Phe Thr Ile Ile Lys Asn Val Glu Ile Ser Asn Phe
    130                 135                 140                 
Val Cys Asp Pro Ser Gln Leu Leu Lys Leu Ala Cys Ser Asp Ser Val
145                 150                 155                 160 
Ile Asn Ser Ile Phe Ile Tyr Phe Asp Ser Thr Met Phe Gly Phe Leu
                165                 170                 175     
Pro Ile Ser Gly Ile Leu Leu Ser Tyr Ser Lys Ile Val Pro Ser Val
            180                 185                 190         
Leu Arg Met Ser Ser Ser Asp Gly Lys Tyr Lys Ala Phe Ser Thr Cys
        195                 200                 205             
Gly Ser His Leu Ala Val Val Cys
    210                 215     


<210> 2931
<211> 289
<212> PRT
<213> Homo sapiens

<400> 2931
Met Pro Leu Glu Lys Val Arg Pro Ser Ser Val Ala Thr Thr Trp Ala
 1               5                  10                  15      
Gly Ile Gly Thr Cys Tyr Cys Asp Gln Lys Glu Lys Ser Asn Lys Lys
            20                  25                  30          
Lys Arg Pro Lys Glu Arg Ile Trp Ser Glu Lys Lys Ile Lys Gln Lys
        35                  40                  45              
Glu Glu Gly Asp Lys Gly Lys Gln Thr Ile Val Val Pro Ile Lys Ile
    50                  55                  60                  
Leu Glu Lys Glu Asn Ile Lys Val Ile Ala Asp Glu Ser Val Gly Asp
65                  70                  75                  80  
Phe Phe Arg Leu Lys Phe Gly Arg Lys Arg Ala Asn Pro Glu Lys Asn
                85                  90                  95      
Ile Gly Gly Thr Gly Ile Arg His Lys Lys Leu Gln Glu Thr Asp Ser
            100                 105                 110         
Pro Ser Gln Leu Val Ala Lys Glu Asn Ile Ile Tyr Thr Val Phe Glu
        115                 120                 125             
Arg Pro Pro Val Leu Ser Asp Ala Gln Gly Leu Ile Asp Val Pro His
    130                 135                 140                 
Asn Trp Tyr Met Ser Val Thr Leu Asn Gln Leu Leu Leu Glu Ser Gln
145                 150                 155                 160 
Glu Lys His Phe Lys Leu Leu Ser Ser Glu Ile Ser Lys Gly Asp Gly
                165                 170                 175     
Asn Leu Gln Leu Leu Cys Met Lys Gln Tyr His Leu Gln Thr Trp Pro
            180                 185                 190         
Ala Gln Pro Leu Leu Gln Thr Leu Thr Asn Trp Ser Gly Leu Leu Ile
        195                 200                 205             
Thr Cys Glu Glu Glu Asn Glu Leu Gly Thr His Leu Thr Lys Asn Lys
    210                 215                 220                 
Ser Glu Lys Ala Arg Lys Asn Glu Ala Ala Glu Lys Val Ser Tyr Asp
225                 230                 235                 240 
Tyr Gln His Thr Gly Glu Lys Pro Tyr Gly Cys Asn Glu Cys Gly Lys
                245                 250                 255     
Ala Phe Thr Phe Lys Ser Gln Leu Ile Val His Gln Arg Val His Ala
            260                 265                 270         
Gly Val Lys Pro Tyr Gly Cys Ser Gln Cys Glu Lys Thr Phe Asn Leu
        275                 280                 285             
Lys
    


<210> 2932
<211> 384
<212> PRT
<213> Homo sapiens

<400> 2932
Met Thr Asn Gly Glu Ile Asp Asp Ala Glu Thr Glu Glu Thr Met Val
 1               5                  10                  15      
Ala Ala Asn Gly Trp Phe Leu Leu Ala Leu Ser His Asn Leu Thr Thr
            20                  25                  30          
Glu Glu Pro Asp Gln Ile Leu Pro His Met Ala Ile Phe Ile Arg Gln
        35                  40                  45              
Thr Gly Lys Glu Ala Ile Ile Gln Ala Phe Arg Lys Asp Ala Cys Glu
    50                  55                  60                  
Ala Lys Glu Ile Pro Cys Thr Thr Ser Ser Val Thr Gly Ser Val Ala
65                  70                  75                  80  
Val Val Gly Val Lys Met Asn Thr Pro Gly Asn Pro Gln Leu Glu Gln
                85                  90                  95      
Arg Arg Gly Asp Thr Tyr Ile Leu Gln Val Ile Lys Leu Gln Glu Trp
            100                 105                 110         
Leu Ser Pro Gln Ser Gln Ser Asn Cys Gly Gln Phe Leu Glu Ile Pro
        115                 120                 125             
Asp Met Ile Glu Gln Glu Lys Pro Gln Ser Leu Arg Phe Glu Asp Leu
    130                 135                 140                 
Asn Lys Gln Tyr Phe Leu Asn Gly Leu Glu Arg Ser Arg Lys Phe Tyr
145                 150                 155                 160 
Glu Ile Ser Ala Glu Lys Lys Pro Gln Gln Arg Ala Lys Ser Ser Ala
                165                 170                 175     
Gly Glu Lys Lys His Thr Pro Val Gly Lys Thr Ser Phe Ser Lys Asn
            180                 185                 190         
Thr Ser Arg Ala Ser Lys Glu Gln Trp Leu Lys His Gln Leu Thr Gly
        195                 200                 205             
Lys Arg Asp Lys Gln Gly Leu Tyr Arg Leu Leu Thr Phe Leu Thr His
    210                 215                 220                 
Gly Ser Ser Lys Glu Val Lys His Leu Leu Tyr Asn Leu Lys Ser Val
225                 230                 235                 240 
Asp Ile Met Ser Ser Ser Pro Gln Val Glu Leu Lys Ile Asp Glu Pro
                245                 250                 255     
Arg Ala Ser Leu Glu Cys Lys Leu Ala Gln His Thr Thr Phe Thr Val
            260                 265                 270         
Ala Val Leu Val Ala Thr Thr Arg Glu Ser Glu Ala Met Ala Val Leu
        275                 280                 285             
Lys Leu Gly Ile Lys Gln Ile Leu Val Leu Lys Tyr Trp Gly Gly Gly
    290                 295                 300                 
Ala Pro Asp Ile Arg Cys His Thr Phe Gln Glu Arg Arg Asp Leu Pro
305                 310                 315                 320 
Pro Thr Phe Ser Ser Gly Lys Ala Thr Ala Val Thr Gln Glu Val Asn
                325                 330                 335     
Arg Ala Glu Glu Val Lys Trp Ala Val Gly Leu Leu Glu Ile Ile Lys
            340                 345                 350         
Glu Gly Asp Gly Leu Ala Thr Thr Val Ala Ser Gly Arg Glu Lys His
        355                 360                 365             
Gln Asn Gln Trp Pro Ala Gly Ser Val Trp Glu Asn Thr Ala Phe Phe
    370                 375                 380                 


<210> 2933
<211> 403
<212> PRT
<213> Homo sapiens

<400> 2933
Met Val Cys Pro Pro Gly Glu Val Pro Val Phe Trp Pro Ser Pro Leu
 1               5                  10                  15      
Thr Ser Leu Gly Ala Val Ser Ser Cys Glu Thr Pro Leu Ala Phe Ala
            20                  25                  30          
Ser Ile Pro Gly Cys Thr Val Met Thr Asp Leu Lys Asp Ala Lys Ala
        35                  40                  45              
Pro Pro Gly Cys Leu Thr Pro Glu Arg Ile Pro Glu Val His His Ile
    50                  55                  60                  
Ser Gln Asp Pro Leu His Tyr Ser Ile Ala Ser Val Ser Ala Ser Gln
65                  70                  75                  80  
Lys Ile Arg Glu Leu Glu Ser Met Ile Gly Ile Asp Pro Gly Asn Arg
                85                  90                  95      
Gly Ile Gly His Leu Leu Cys Lys Asp Glu Leu Leu Lys Ala Ser Leu
            100                 105                 110         
Ser Leu Ser His Ala Arg Ser Val Leu Ile Thr Thr Gly Phe Pro Thr
        115                 120                 125             
His Phe Asn His Glu Pro Pro Glu Glu Thr Asp Gly Pro Pro Gly Ala
    130                 135                 140                 
Val Ala Leu Val Ala Phe Leu Gln Ala Leu Glu Lys Glu Val Ala Ile
145                 150                 155                 160 
Ile Val Asp Gln Arg Ala Trp Asn Leu His Gln Lys Ile Val Glu Asp
                165                 170                 175     
Ala Val Glu Gln Gly Val Leu Lys Thr Gln Ile Pro Ile Leu Thr Tyr
            180                 185                 190         
Gln Gly Gly Ser Val Glu Ala Ala Gln Ala Phe Leu Cys Lys Asn Gly
        195                 200                 205             
Asp Pro Gln Thr Pro Arg Phe Asp His Leu Val Ala Ile Glu Arg Ala
    210                 215                 220                 
Gly Arg Ala Ala Asp Gly Asn Tyr Tyr Asn Ala Arg Lys Met Asn Ile
225                 230                 235                 240 
Lys His Leu Val Asp Pro Ile Asp Asp Leu Phe Leu Ala Ala Lys Lys
                245                 250                 255     
Ile Pro Gly Ile Ser Ser Thr Gly Val Gly Asp Gly Gly Asn Glu Leu
            260                 265                 270         
Gly Met Gly Lys Val Lys Glu Ala Val Arg Arg His Ile Arg His Gly
        275                 280                 285             
Asp Val Ile Ala Cys Asp Val Glu Ala Asp Phe Ala Val Ile Ala Gly
    290                 295                 300                 
Val Ser Asn Trp Gly Gly Tyr Ala Leu Ala Cys Ala Leu Tyr Ile Leu
305                 310                 315                 320 
Tyr Ser Cys Ala Val His Ser Gln Tyr Leu Arg Lys Ala Val Gly Pro
                325                 330                 335     
Ser Arg Ala Pro Gly Asp Gln Ala Trp Thr Gln Ala Leu Pro Ser Val
            340                 345                 350         
Ile Lys Glu Glu Lys Met Leu Gly Ile Leu Val Gln His Lys Val Arg
        355                 360                 365             
Ser Gly Val Ser Gly Ile Val Gly Met Glu Val Asp Gly Leu Pro Phe
    370                 375                 380                 
His Asn Thr His Ala Glu Met Ile Gln Lys Leu Val Asp Val Thr Thr
385                 390                 395                 400 
Ala Gln Val
            


<210> 2934
<211> 972
<212> PRT
<213> Homo sapiens

<400> 2934
Met Pro His Phe Leu Leu Ala Ile Cys Phe Val Gln Lys Val Val Phe
 1               5                  10                  15      
Leu Cys Ala Phe Tyr Ser Trp Ala Lys Ala Ser Arg Thr Phe Leu Lys
            20                  25                  30          
Ala Asp Gly Leu Pro Arg Arg Lys Gln Trp Val Leu Val Glu Ala Leu
        35                  40                  45              
Ala Gly Gly Gly Val Leu Gly Val Ser Glu Ala Cys His Pro Ser Ser
    50                  55                  60                  
Gly Lys Ala Arg Cys Gly Leu Glu Ser Glu Val Lys Arg Ala Gly Pro
65                  70                  75                  80  
Cys Ser Arg Gly Pro Gly Asn Gln Gln Asp Leu Gly Glu Pro Val Pro
                85                  90                  95      
Arg Asn Ser Arg Gly Glu Ala Pro Asp His Gln Leu Phe Glu Tyr Val
            100                 105                 110         
Val Tyr Val Ala Glu Gln Ile Thr Ile Gln Val Leu Phe Glu Val Leu
        115                 120                 125             
Leu Arg Arg Gly Lys Glu Ser Glu Thr Tyr Thr Lys Met Tyr Arg Arg
    130                 135                 140                 
Leu Gly Pro Glu Arg Cys Arg Arg Ser Lys Tyr Ala Gly Val Glu Arg
145                 150                 155                 160 
Ile Val Asp Lys Arg Lys Asn Lys Lys Gly Lys Trp Glu Tyr Leu Ile
                165                 170                 175     
Arg Trp Lys Gly Tyr Gly Ser Thr Glu Asp Thr Trp Glu Pro Glu His
            180                 185                 190         
His Leu Leu His Cys Glu Glu Phe Ile Asp Glu Phe Asn Gly Leu His
        195                 200                 205             
Met Ser Lys Asp Lys Arg Ile Lys Ser Gly Lys Gln Ser Ser Thr Ser
    210                 215                 220                 
Lys Leu Leu Arg Asp Ser Arg Gly Pro Ser Val Glu Lys Leu Ser His
225                 230                 235                 240 
Arg Pro Ser Asp Pro Gly Lys Ser Lys Gly Thr Ser His Lys Arg Lys
                245                 250                 255     
Arg Ile Asn Pro Pro Leu Ala Lys Pro Lys Lys Gly Tyr Ser Gly Lys
            260                 265                 270         
Pro Ser Ser Gly Gly Asp Arg Ala Thr Lys Thr Val Ser Tyr Arg Thr
        275                 280                 285             
Thr Pro Ser Gly Leu Gln Ile Met Pro Leu Lys Lys Ser Gln Asn Gly
    290                 295                 300                 
Met Glu Asn Gly Asp Ala Gly Ser Glu Lys Asp Glu Arg His Phe Gly
305                 310                 315                 320 
Asn Gly Ser His Gln Pro Gly Leu Asp Leu Asn Asp His Val Gly Glu
                325                 330                 335     
Gln Asp Met Gly Glu Cys Asp Val Asn His Ala Thr Leu Ala Glu Asn
            340                 345                 350         
Gly Leu Asp Thr Cys Val Ser Thr Trp Trp His Leu Ser Leu Trp Leu
        355                 360                 365             
Pro Glu Thr Arg Ala Leu Glu Cys Pro Glu Ile Leu Gln Glu Cys Gly
    370                 375                 380                 
Gln Pro Leu Pro Asn Arg Ala Gly Pro Ser Asp Ser Leu Met Lys Pro
385                 390                 395                 400 
Gly Ile Thr Thr Ala Ser Leu Gly Glu Glu Leu Val Pro Glu Glu Ala
                405                 410                 415     
Gln Gly Asn Trp Phe Arg Lys Ala Leu Thr Val Ile Gly Ser Gly Pro
            420                 425                 430         
Thr Leu Ser Gly Glu Pro Leu Arg Gly Ser Ile Glu Ala Lys Lys Leu
        435                 440                 445             
Ile Arg Ala Gly Arg Thr Val Gly Ala Gln Asn Arg Arg Ala Ser Cys
    450                 455                 460                 
Pro Ala Leu Gln Pro Met Arg Gly Met Trp Asp Leu Asn Ala Gly Ser
465                 470                 475                 480 
Ala Pro Asp Trp Thr Ser Pro Trp Leu Leu Gly Ser Ala Glu His Val
                485                 490                 495     
Phe Pro Ala Ser Leu Leu Leu Ser Leu Gly Lys His Asp Ala Pro Glu
            500                 505                 510         
Gly Glu Gly Pro Arg Gly Leu Leu Gly Ser Trp Ser Ile Ser Val Ser
        515                 520                 525             
Tyr Ile Val Tyr Leu Val Leu Glu Gly Ser Ala Leu Thr Asn Gly Gly
    530                 535                 540                 
Leu Asn Leu His Ser Pro Val Lys Arg Lys Leu Glu Ala Glu Lys Asp
545                 550                 555                 560 
Tyr Val Phe Asp Lys Arg Leu Arg Tyr Ser Val Arg Gln Asn Glu Ser
                565                 570                 575     
Asn Cys Arg Phe Arg Asp Ile Val Val Arg Lys Glu Glu Gly Phe Thr
            580                 585                 590         
His Ile Leu Leu Ser Ser Gln Thr Ser Asp Asn Asn Ala Leu Thr Pro
        595                 600                 605             
Glu Gly Arg Leu Pro Ala Gln Ala Glu Ala Asp Ser Leu Ala Ser Thr
    610                 615                 620                 
Leu Arg Gly Ser Gly Leu Trp Leu Ser Cys Ser Leu Lys Ala Pro Gly
625                 630                 635                 640 
Leu Gln Asp Arg His Leu Thr Ser Leu Gln Ile His Leu Cys Arg Gln
                645                 650                 655     
Ile Met Lys Glu Val Arg Arg Ala Leu Cys Asn Ala Ala Thr Asp Asp
            660                 665                 670         
Ser Lys Leu Leu Leu Leu Ser Ala Val Gly Ser Val Phe Cys Ser Gly
        675                 680                 685             
Leu Asp Tyr Ser Tyr Leu Ile Gly Arg Leu Ser Ser Asp Arg Arg Lys
    690                 695                 700                 
Glu Ser Thr Arg Ile Ala Glu Ala Ile Ser Pro Ala Ile Ala Glu Gly
705                 710                 715                 720 
Ser Asp Ile Gly Ala Ala Gly Pro Val Met Gln Tyr Pro Val Cys Cys
                725                 730                 735     
Leu Ala Pro Ser Asp Arg Asp Leu Leu Pro Glu Val Gly Lys His Arg
            740                 745                 750         
Met Lys Gly Ser Gly Val Leu Gln Arg Lys Ala Leu Glu Ser His Lys
        755                 760                 765             
Gly Cys Ser Pro Phe Leu Lys Asp Val Met Trp Leu Met Glu Leu Arg
    770                 775                 780                 
Asp Phe Val Lys Ala Phe Ile Gln Phe Lys Lys Pro Ile Val Val Ala
785                 790                 795                 800 
Ile Asn Gly Pro Ala Leu Gly Leu Gly Ala Ser Ile Leu Pro Leu Cys
                805                 810                 815     
Asp Ile Val Trp Ala Ser Glu Lys Ala Trp Phe Gln Thr Pro Tyr Ala
            820                 825                 830         
Thr Ile Arg Leu Thr Pro Ala Gly Cys Ser Ser Tyr Thr Phe Pro Gln
        835                 840                 845             
Ile Leu Gly Val Ala Leu Leu Ser Val Leu Glu Gly Gly Pro Thr Leu
    850                 855                 860                 
Phe Arg Glu Asp Pro Phe Glu Gln Ala Asn Glu Met Leu Phe Cys Gly
865                 870                 875                 880 
Arg Lys Leu Thr Ala Gln Glu Ala Cys Ser Arg Gly Leu Val Ser Gln
                885                 890                 895     
Val Phe Trp Pro Thr Thr Phe Ser Gln Glu Val Met Leu Arg Val Lys
            900                 905                 910         
Glu Met Ala Ser Cys Ser Ala Val Val Leu Glu Glu Ser Lys Cys Leu
        915                 920                 925             
Val Arg Ser Phe Leu Lys Ser Val Leu Glu Asp Val Asn Glu Lys Glu
    930                 935                 940                 
Cys Leu Met Leu Lys Gln Leu Trp Ser Ser Ser Lys Gly Leu Asp Ser
945                 950                 955                 960 
Leu Phe Ser Tyr Leu Gln Asp Lys Ile Tyr Glu Val
                965                 970         


<210> 2935
<211> 833
<212> PRT
<213> Homo sapiens

<400> 2935
Met Val Pro Ser Arg Arg Thr Trp Asn Leu Gly Ala Thr Pro Ser Leu
 1               5                  10                  15      
Arg Gly Leu Trp Arg Val Gly Arg Ala Pro Glu Pro Glu Pro Gly Met
            20                  25                  30          
Ala Arg Pro Ala Pro Ala Pro Ala Ser Pro Ala Ala Arg Pro Phe Pro
        35                  40                  45              
His Thr Gly Pro Gly Arg Leu Arg Thr Gly Arg Gly Lys Asp Thr Pro
    50                  55                  60                  
Val Cys Gly Asp Glu Asp Ser Ser Ala Arg Ser Ala Ala Arg Pro Ala
65                  70                  75                  80  
Leu Ala Gln Cys Arg Ala Leu Ser Val Asp Trp Ala Gly Pro Gly Ser
                85                  90                  95      
Pro His Gly Leu Tyr Leu Thr Leu Gln Val Glu His Leu Lys Glu Lys
            100                 105                 110         
Leu Ile Ser Gln Ala Gln Glu Val Ser Arg Leu Arg Ser Glu Leu Gly
        115                 120                 125             
Gly Thr Asp Leu Glu Lys His Arg Asp Leu Leu Met Val Glu Asn Glu
    130                 135                 140                 
Arg Leu Arg Gln Glu Met Arg Arg Cys Glu Ala Glu Leu Gln Glu Leu
145                 150                 155                 160 
Arg Thr Lys Pro Ala Gly Pro Cys Pro Gly Cys Glu His Ser Gln Glu
                165                 170                 175     
Ser Ala Gln Leu Arg Asp Lys Leu Ser Gln Leu Gln Leu Glu Met Ala
            180                 185                 190         
Glu Ser Lys Gly Met Leu Ser Glu Leu Asn Leu Glu Val Gln Gln Lys
        195                 200                 205             
Thr Asp Arg Leu Ala Glu Val Glu Leu Arg Leu Lys Asp Cys Leu Ala
    210                 215                 220                 
Glu Lys Ala Gln Glu Glu Glu Arg Leu Ser Arg Arg Leu Arg Asp Ser
225                 230                 235                 240 
His Glu Thr Ile Ala Ser Leu Arg Ala Gln Ser Pro Pro Val Lys Tyr
                245                 250                 255     
Val Ile Lys Thr Val Glu Val Glu Ser Ser Lys Thr Lys Gln Ala Leu
            260                 265                 270         
Ser Glu Ser Gln Ala Arg Asn Gln His Leu Gln Glu Gln Val Ala Met
        275                 280                 285             
Gln Arg Gln Val Leu Lys Glu Met Glu Gln Gln Leu Gln Ser Ser His
    290                 295                 300                 
Gln Leu Thr Ala Arg Leu Arg Ala Gln Ile Ala Met Tyr Glu Ser Glu
305                 310                 315                 320 
Leu Glu Arg Ala His Gly Gln Met Leu Glu Glu Met Gln Ser Leu Glu
                325                 330                 335     
Glu Asp Lys Asn Arg Ala Ile Glu Glu Ala Phe Ala Arg Ala Gln Val
            340                 345                 350         
Glu Met Lys Ala Val His Glu Asn Leu Ala Gly Val Arg Thr Asn Leu
        355                 360                 365             
Leu Thr Leu Gln Pro Ala Leu Arg Thr Leu Thr Asn Asp Tyr Asn Gly
    370                 375                 380                 
Leu Lys Arg Gln Val Arg Gly Phe Pro Leu Leu Leu Gln Glu Ala Leu
385                 390                 395                 400 
Arg Ser Val Lys Ala Glu Ile Gly Gln Ala Ile Glu Glu Val Asn Ser
                405                 410                 415     
Asn Asn Gln Glu Leu Leu Arg Lys Tyr Arg Arg Glu Leu Gln Leu Arg
            420                 425                 430         
Lys Lys Cys His Asn Glu Leu Val Arg Leu Lys Gly Asn Ile Arg Val
        435                 440                 445             
Ile Ala Arg Val Arg Pro Val Thr Lys Glu Asp Gly Glu Gly Pro Glu
    450                 455                 460                 
Ala Thr Asn Ala Val Thr Phe Asp Ala Asp Asp Asp Ser Ile Ile His
465                 470                 475                 480 
Leu Leu His Lys Gly Lys Pro Val Ser Phe Glu Leu Asp Lys Val Phe
                485                 490                 495     
Ser Pro Gln Ala Ser Gln Gln Asp Val Phe Gln Glu Val Gln Ala Leu
            500                 505                 510         
Val Thr Ser Cys Ile Asp Gly Phe Asn Val Cys Ile Phe Ala Tyr Gly
        515                 520                 525             
Gln Thr Gly Ala Gly Lys Thr Tyr Thr Met Glu Gly Thr Ala Glu Asn
    530                 535                 540                 
Pro Gly Ile Asn Gln Arg Ala Leu Gln Leu Leu Phe Ser Glu Val Gln
545                 550                 555                 560 
Glu Lys Ala Ser Asp Trp Glu Tyr Thr Ile Thr Val Ser Ala Ala Glu
                565                 570                 575     
Ile Tyr Asn Glu Val Leu Arg Asp Leu Leu Gly Lys Glu Pro Gln Glu
            580                 585                 590         
Lys Leu Glu Ile Arg Leu Cys Pro Asp Gly Ser Gly Gln Leu Tyr Val
        595                 600                 605             
Pro Gly Leu Thr Glu Phe Gln Val Gln Ser Val Asp Asp Ile Asn Lys
    610                 615                 620                 
Val Phe Glu Phe Gly His Thr Asn Arg Thr Thr Glu Phe Thr Asn Leu
625                 630                 635                 640 
Asn Glu His Ser Ser Arg Ser His Ala Leu Leu Ile Val Thr Val Arg
                645                 650                 655     
Gly Val Asp Cys Ser Thr Gly Leu Arg Thr Thr Gly Lys Leu Asn Leu
            660                 665                 670         
Val Asp Leu Ala Gly Ser Glu Arg Val Gly Lys Ser Gly Ala Glu Gly
        675                 680                 685             
Ser Arg Leu Arg Glu Ala Gln His Ile Asn Lys Ser Leu Ser Ala Leu
    690                 695                 700                 
Gly Asp Val Ile Ala Ala Leu Arg Ser Arg Gln Gly His Val Pro Phe
705                 710                 715                 720 
Arg Asn Ser Lys Leu Thr Tyr Leu Leu Gln Asp Ser Leu Ser Gly Asp
                725                 730                 735     
Ser Lys Thr Leu Met Val Val Gln Val Ser Pro Val Glu Lys Asn Thr
            740                 745                 750         
Ser Glu Thr Leu Tyr Ser Leu Lys Phe Ala Glu Arg Val Arg Ser Val
        755                 760                 765             
Glu Leu Gly Pro Gly Leu Arg Arg Ala Glu Leu Gly Ser Trp Ser Ser
    770                 775                 780                 
Gln Glu His Leu Glu Trp Glu Pro Ala Cys Gln Thr Pro Gln Pro Ser
785                 790                 795                 800 
Ala Arg Ala His Ser Ala Pro Ser Ser Gly Thr Ser Ser Arg Pro Gly
                805                 810                 815     
Ser Ile Arg Arg Lys Leu Gln Pro Ser Gly Lys Ser Arg Pro Leu Pro
            820                 825                 830         
Val
    


<210> 2936
<211> 1915
<212> PRT
<213> Homo sapiens

<400> 2936
Met Gly Ala Val Lys Leu Gly Thr Arg Tyr Asn Arg Ile Ser Asn Val
 1               5                  10                  15      
Leu Phe Leu Lys Leu Val Gly His Val Gly Ala Gly Cys Ile Ile Leu
            20                  25                  30          
Ser Thr Phe Trp Asn Ala Leu Asn Ile Ser Gln Leu Asp Thr Leu Lys
        35                  40                  45              
Ala Val Glu Pro Pro Trp Thr Glu Pro Pro Arg Lys Pro Thr Phe Pro
    50                  55                  60                  
Arg Ala Glu Gly Pro Thr Arg Gly Gly Leu Arg Gly Leu Cys Ala Gly
65                  70                  75                  80  
Gly Ala Gln Gln Thr Arg Gln Pro Thr Met Gly Ala Gly Ser Leu Thr
                85                  90                  95      
Pro Pro Ser Met Arg Ala Gly Gly Gly Gly Ser Gln Gly Lys Leu Leu
            100                 105                 110         
Asn Leu Asn Gln Thr Phe Arg Arg Ala Ala Gly Asp Val Arg Leu Pro
        115                 120                 125             
Pro His Cys Ser Pro Thr Ala Gln Gly His Gln Ser Pro Gly Lys Arg
    130                 135                 140                 
Gly Lys Gly Asp Ala Asp Val Cys Val Phe Arg Gln Gln Ser Arg Leu
145                 150                 155                 160 
Ser Leu Pro Arg Ser Pro Thr Ala Arg Met Phe Ile Leu Pro Gly Gly
                165                 170                 175     
Gln Gln Pro Gly Ala Ser Ser Glu Pro Glu Arg Tyr Arg Arg Leu Val
            180                 185                 190         
Thr Ser Gly Gln Arg Ser Pro Gly Arg Leu Glu Val Ser Cys Gly Pro
        195                 200                 205             
Pro Arg Arg Gly Ala Arg Ser Thr Val Ala Pro Gly Cys Leu Glu Phe
    210                 215                 220                 
Pro Ser Pro Ala Pro Pro Gln Trp Ala Cys Ile Arg Thr Ala Gly Arg
225                 230                 235                 240 
Lys Leu Ala Ala Asn Pro Leu Leu Pro Pro Gly Gly Glu Lys Ala His
                245                 250                 255     
Leu Pro Val Gly Val Ile Tyr Asp Pro Ile Thr Ala Glu Ala Ser Glu
            260                 265                 270         
Gly Leu Gln Asp Gly Trp Pro Ala Ala Ser Arg Glu Arg Gly Gly Glu
        275                 280                 285             
Asn Thr Cys Arg Ala Pro Glu Lys Glu Leu Ser Ala Thr Gly Ser Gly
    290                 295                 300                 
Arg Met Gln Gly Arg Ile Ser Tyr Leu Leu Gly Cys Leu Pro Glu Gly
305                 310                 315                 320 
Pro Gln Gly Ala Glu Lys Pro Ser Lys Thr Arg Thr Gly Leu Leu Cys
                325                 330                 335     
Pro Leu Leu Cys Val Pro Ser Trp Ile Leu Ala Leu Glu Asp Leu Phe
            340                 345                 350         
Pro Val Leu His Ala Ser Ile Asn Ile Leu Ser Pro Gln Glu Ser Leu
        355                 360                 365             
Gly Phe Ile Ser Trp Ser Ser Ser Arg Ser Leu Lys Asn Arg Ala Leu
    370                 375                 380                 
Arg His Pro Glu Gln Ser Thr His Thr Pro Gly Pro Ser Pro Gly Val
385                 390                 395                 400 
Gly Ser Glu Pro Gly His Arg Gln Gly Gln Arg Val Thr Met Trp Pro
                405                 410                 415     
Leu Lys Gln Arg Ser Pro Arg Pro Gly Pro Met Asp Leu Ile Ser Leu
            420                 425                 430         
Val Trp Glu Ala Asn Pro Val Ser Glu Gly Leu Val Thr Thr Arg Arg
        435                 440                 445             
Pro Ser Leu Pro Pro Pro Gln Ser Arg Phe Ala Arg Val Gly Glu His
    450                 455                 460                 
Pro Ile Trp Pro Pro Ser Val Leu Val Gln Gly Ser Ser Gln Val Glu
465                 470                 475                 480 
Glu Arg Glu Gln Gln Gln Ser Arg Glu Glu Thr Ala Glu Gln His Gly
                485                 490                 495     
Gly Ser His Lys Asp Arg Asp Glu Ala Pro Ser His Cys Gly Asp Ser
            500                 505                 510         
Pro Pro Pro Thr Thr Ser Arg Thr Glu Pro Gly Leu Cys Ser Cys Val
        515                 520                 525             
Ser Ser Gln Asp His Thr Pro Gly Arg Gln Ala Gly Arg Ala Glu Pro
    530                 535                 540                 
Pro Ala His Ser Ala His Thr Thr Arg Pro Gln Ala Leu Ser Val Pro
545                 550                 555                 560 
Lys Ser Ala Ile Lys Glu Pro Gly Gly Glu Ala Glu Gln Arg Val Gln
                565                 570                 575     
Ser Leu Phe Gly Leu Gly Met Lys Arg Glu Lys Pro Gly Val Cys Thr
            580                 585                 590         
Phe Phe Gly Gly Ala Val Ala Leu Cys Asp Thr Arg Cys Phe Pro Asp
        595                 600                 605             
Met Gly Ala Gly Leu Gly Pro Thr Leu Met Gly Ala Leu Gly Leu Val
    610                 615                 620                 
Lys Met Arg Arg Glu Pro Pro Ser Trp Leu Arg Ser Cys Ser Ser Glu
625                 630                 635                 640 
Thr Pro Ala Leu Pro Leu Thr Trp Gly Ser Pro Ser Gln Gly Val Glu
                645                 650                 655     
Gly Pro Gly His Ser Pro Ala Leu Ala Val Lys Pro Ala Met Met Glu
            660                 665                 670         
Glu Gly Glu Gly Glu Lys Pro Leu Thr Pro His Leu Pro Glu Glu Gln
        675                 680                 685             
Arg Trp Pro Arg Ser Ser Val Ser Ser Pro Trp Pro Gly Glu Gly Thr
    690                 695                 700                 
Arg Gly Ala Glu Gln Arg Gly Arg Ala Glu Ser Pro Ala Leu Glu Leu
705                 710                 715                 720 
Tyr Ser Arg Gln Pro Ala Ser Gly His Leu Pro Asp Gly His Phe Lys
                725                 730                 735     
Cys Asn Thr Trp Glu Pro Lys Leu Pro Thr Trp Met Pro Arg Thr Gln
            740                 745                 750         
Gly Gly Thr Val Ser Glu Leu Gly Ser Gly Ser Pro His Pro Cys Trp
        755                 760                 765             
Asp Asn Arg Ile Pro Ala Gln Tyr Pro Glu Ile Gln Lys Glu Leu Ala
    770                 775                 780                 
Ser Thr Cys Thr Ser Lys Pro His Leu Leu Gly His Pro Lys Leu Glu
785                 790                 795                 800 
Leu Leu Glu Pro Ser Arg Gln Leu Ala Ser Thr Ala Arg Ser Pro Glu
                805                 810                 815     
Ala Ser Lys Arg Glu Pro Glu Ala Lys Pro Lys Gly Pro Ala Leu Ser
            820                 825                 830         
Cys Pro Leu Ala Val Glu Asn Arg Trp Gly Gly Thr Trp Phe Gly Ala
        835                 840                 845             
Arg Pro Gly Gly Asp Gln Leu Tyr Ala Thr Ser Trp Pro Glu Ser His
    850                 855                 860                 
Leu Trp Leu Thr Asn Thr Asp Ile Ser Ser Arg Ser Leu His Gln Gly
865                 870                 875                 880 
Glu Ser Lys Gly Ala Gln Asn Trp Trp Asp Pro Pro Gly Thr Trp Gln
                885                 890                 895     
His Trp Pro Leu Thr Thr Asp Ser Arg Val Pro Pro Arg Val Leu Pro
            900                 905                 910         
Pro Ala Lys Gly Thr Asp Pro Cys Glu Gly Gln Asp Cys Lys Ala Gly
        915                 920                 925             
Leu Asp Ser Gln Gly Ser Leu Val Asn Ile Asn Gly His Ala Arg Leu
    930                 935                 940                 
Trp Gly Thr Gln Gly Phe Val Ile Met Asp Tyr Leu Leu Leu Ser Thr
945                 950                 955                 960 
Ile Leu Lys Val Glu Thr Lys Val Leu Ser Gln Cys His Ile Pro Val
                965                 970                 975     
Pro Glu Ile Trp Ile Ala Asp Pro His Pro Gln Thr Ile Ser Asn Leu
            980                 985                 990         
Gly Thr Ala Leu Pro Gly Pro Gly Thr Ala Ser Ser Ala Gln Pro Leu
        995                 1000                1005            
Lys Glu Thr Tyr Leu Ser Tyr Ser Leu Cys Pro Ala Phe Ser Ala Gly
    1010                1015                1020                
Pro Pro Phe Gln Arg His Pro Leu Phe Met His Lys Trp Leu Gly Glu
1025                1030                1035                1040
Gly Cys Gly Ser Glu Met Phe Asn Arg Leu Pro Asn Val Arg Gln Pro
                1045                1050                1055    
Glu Asp Asp Arg Leu Ser Pro Trp Cys Ala Leu Asn Leu Thr Glu Thr
            1060                1065                1070        
Asp Pro Gln His Met Arg Ser Glu Glu Glu Glu Phe Ile Gln Gln Val
        1075                1080                1085            
Ser Gln Lys Asp Met Arg Val Gly Ala Gly Asp Ser Lys Gly Ser Gly
    1090                1095                1100                
Glu Glu Ser Arg Val Gly Gly Ile His Leu Pro Met Thr Val Thr Ala
1105                1110                1115                1120
Pro Arg Leu Arg Ala Pro Gly Lys Asn Arg Thr Gly Gly Gln Gln Glu
                1125                1130                1135    
Gln Asp Glu Gln Gly Gln His Pro Gln Val Gln His Arg Glu Gly Val
            1140                1145                1150        
Ala Ser Val Phe Ile Leu Leu Ile Gln Arg Gly Arg Arg His Gly Ser
        1155                1160                1165            
Gly Ala Leu Gln Pro Leu Thr Val Pro Gln His Gln Leu Pro Ser Pro
    1170                1175                1180                
Ser Ser Lys Asp Ser His Lys Asp Lys Pro Gly His Ser Val Ser Lys
1185                1190                1195                1200
Ser Leu Ala His Ile Cys Lys Ala Ser Leu Arg Gln Ser Lys Trp Ala
                1205                1210                1215    
Thr Asn Ser Ile Leu Pro Phe Arg Gly Leu Gln Gln Pro Ser Glu Gly
            1220                1225                1230        
Ser Gly Asn Val Lys Ala Leu Ala Leu Asn Ala Val Ser His Pro Glu
        1235                1240                1245            
Thr Ala Gln Lys Arg Ser Ile Glu Pro Cys Asp Pro Ile Phe Gly Phe
    1250                1255                1260                
Glu Thr Ala Ala Leu Gln Val Pro Gly Pro Pro Glu Ile Ala Ser His
1265                1270                1275                1280
Val Leu Pro Gln Asp Ser Val Ser Thr Thr Asn His Lys Arg Arg Ala
                1285                1290                1295    
Ala Arg Leu Thr Ala Ala Trp Leu Arg Arg Asp Ser Ile Gln Arg Leu
            1300                1305                1310        
Pro Leu Gly Leu Pro Leu His Cys Pro Thr Gln Cys Pro Gly Thr Asp
        1315                1320                1325            
Arg Lys Phe Trp Val Thr Arg Leu Leu Phe Gln Asn Phe Leu His Lys
    1330                1335                1340                
Phe Leu Thr Thr Asp Gly Gly Lys Leu Val Phe Ser Leu Ala Leu Arg
1345                1350                1355                1360
Pro Ser Ile Tyr Arg Leu Gly Ile Cys Leu Asn Val Lys Arg Glu Glu
                1365                1370                1375    
Glu Glu Lys Gly Gly Gly Gly Leu Val Arg Gly Gly Gln Ser Thr Asp
            1380                1385                1390        
Leu His Cys Pro Leu Leu Ala Thr Gly Ser Pro Val Pro Leu Pro Leu
        1395                1400                1405            
Trp Thr Ser Val Thr Pro Pro Pro Val Gly Glu Thr Ser Asp Gln Ser
    1410                1415                1420                
Leu Leu Glu Arg Ser Ser Pro Gly Arg Glu Asp Thr Arg Thr Ser Gly
1425                1430                1435                1440
Trp Glu Pro His Thr Asp Ala Gly Leu Gly His Gly Ile Leu His Ala
                1445                1450                1455    
Ser Pro Leu Pro Val Arg His Lys Leu Lys Thr Gly Thr Gln Arg Arg
            1460                1465                1470        
Leu Lys Thr Phe Pro Arg Asp Ser Trp Glu Val Ala Ala Phe Thr Ser
        1475                1480                1485            
Pro Tyr Phe Gly Glu Thr Ala Leu Gly Val Gln Gly Arg Glu Ala Lys
    1490                1495                1500                
Pro Ala Trp Ala Thr Leu Val Pro Glu Val Glu Leu Ala Gln Leu Leu
1505                1510                1515                1520
Gln Gln Cys Ala Arg Thr Pro Pro Thr Ser Pro Asp Met Arg Thr Val
                1525                1530                1535    
Ala Gly Gly Ile Gln Gly Pro Lys Arg Ala Thr Asp Arg Ala Thr Arg
            1540                1545                1550        
Pro Arg Tyr Thr Ala Gln Gly Ala Leu Glu Lys Asp Pro Arg Gly Thr
        1555                1560                1565            
Glu Ala Glu Ala His Gly Val Pro Gln Gly Gly Lys Arg Arg Ile Arg
    1570                1575                1580                
Lys Gln Ser Leu Gly Glu Glu Pro His Leu Thr Ser Leu Leu Pro Gly
1585                1590                1595                1600
Gly Ser Cys Pro Arg Cys Arg His Ser Pro Arg Arg Glu Ile Thr Lys
                1605                1610                1615    
Pro Ala Pro Glu Asp Leu Glu Pro Ala Ile Ser Phe Thr Ala Glu Ser
            1620                1625                1630        
Lys Phe Pro Asn Ser Gln Ala Arg Ala Cys Val His Pro Arg Phe Thr
        1635                1640                1645            
Arg Glu Glu Thr Glu Ala Gly Pro Gly Arg Ser Arg Phe Pro Arg Gln
    1650                1655                1660                
Val Thr Gly Arg Ser Gly Leu Gly Gly Phe Pro Gly Phe Pro Cys Gly
1665                1670                1675                1680
Gln Val Lys Ala Gly Arg Gly Val Gly Glu Asp Ile Glu Lys Ala Ala
                1685                1690                1695    
Gln Asp Ser Glu Ile Gln Val Leu Pro Leu Ala Leu Pro Pro Leu Ala
            1700                1705                1710        
Cys His Leu Gln Thr Gly Pro Phe Leu Asn Arg His Arg Asn Ser Asn
        1715                1720                1725            
Ile Pro Asp Pro Ala Pro Gly Ala Phe Arg Thr Lys Pro Leu Asn Asn
    1730                1735                1740                
Ser Gly Leu Gln Pro Pro Pro Met Ser Val Cys Tyr Gly Ser Asp Thr
1745                1750                1755                1760
Glu Asn Gly His Phe Pro Ala Pro Cys Ser Gly Thr Arg Gln Thr Leu
                1765                1770                1775    
Pro Asn Cys Leu Leu Ser Gly Glu Ala Gly Trp Gly Ser His Thr Gly
            1780                1785                1790        
Leu Leu Arg Asp Glu Gly Thr Ala Arg Ala Gly Glu Ala Glu Glu Gln
        1795                1800                1805            
Glu Arg Met Gln Asp Met Ala Leu Ala Gly His Leu Val Ser Met Thr
    1810                1815                1820                
Arg Pro Arg His Ser Pro Pro Ala Gly Leu Val His Glu Pro Glu Phe
1825                1830                1835                1840
Ser Val Thr Pro Gln Asn Thr His Leu Pro Pro Pro Ala Gln Ser Pro
                1845                1850                1855    
Ser Pro Glu Thr Gly Arg Glu Ala Arg Gly Ala Gly Glu Thr Arg Val
            1860                1865                1870        
Gln Leu Trp Arg Ala Ala Pro Gly Ala Gly Arg Val Thr Arg Trp Ser
        1875                1880                1885            
Pro Arg Pro Pro Thr Leu Ser Arg Val Glu Ala His Phe Ala Lys Ala
    1890                1895                1900                
Ser Leu Pro Pro Glu Leu Leu Pro Thr Arg Pro
1905                1910                1915


<210> 2937
<211> 139
<212> PRT
<213> Homo sapiens

<400> 2937
Met Ser Lys His Gly Gly Trp Ala Ala Ala Ala Ser Ala Lys Pro Val
 1               5                  10                  15      
Arg Thr Ala Ser Ser Pro His Asn Gly Gly His Ala Lys Asp Glu Arg
            20                  25                  30          
Thr Ala Val Gln Ser Leu Ser Ser Ser Leu Leu Leu Asn Ser Pro Leu
        35                  40                  45              
Met Ser Val Ser Ala Phe Thr His Leu Val Ala Leu Leu Glu Pro His
    50                  55                  60                  
Cys Val Leu Lys Ala Phe Pro Ala Ser Phe Cys Phe Leu Leu Pro Phe
65                  70                  75                  80  
Ser Val Ser Gly Lys Tyr Thr Phe Asp Ile Val Thr Gly Ala Glu Gly
                85                  90                  95      
Ala Val Ala Glu Glu Val Glu Arg Val Lys Val Thr Leu Arg Gln Arg
            100                 105                 110         
Leu Gly Ile Gly Trp Ser Gly Thr Gly Lys Gln Met Glu Asp Val Val
        115                 120                 125             
Glu Thr His Lys Arg Leu Gln Phe Gly Glu Gly
    130                 135                 


<210> 2938
<211> 927
<212> PRT
<213> Homo sapiens

<400> 2938
Met Ala His Glu Ser Ala Glu Asp Leu Phe His Phe Asn Val Gly Gly
 1               5                  10                  15      
Trp His Phe Ser Val Pro Arg Ser Lys Leu Ser Gln Phe Pro Asp Ser
            20                  25                  30          
Leu Leu Trp Lys Glu Ala Ser Ala Leu Thr Ser Ser Glu Ser Gln Arg
        35                  40                  45              
Leu Phe Ile Asp Arg Asp Gly Ser Thr Phe Arg His Val His Tyr Tyr
    50                  55                  60                  
Leu Tyr Thr Ser Lys Leu Ser Phe Ser Ser Cys Ala Glu Leu Asn Leu
65                  70                  75                  80  
Leu Tyr Glu Gln Ala Leu Gly Leu Gln Leu Met Pro Leu Leu Gln Thr
                85                  90                  95      
Leu Asp Asn Leu Lys Glu Gly Lys His His Leu Arg Val Arg Pro Ala
            100                 105                 110         
Asp Leu Pro Val Ala Glu Arg Ala Ser Leu Asn Tyr Trp Arg Thr Trp
        115                 120                 125             
Lys Cys Ile Ser Lys Pro Ser Glu Phe Pro Ile Lys Ser Pro Ala Phe
    130                 135                 140                 
Thr Gly Leu His Asp Lys Ala Pro Leu Gly Leu Met Asp Thr Pro Leu
145                 150                 155                 160 
Leu Asp Thr Glu Glu Glu Val His Tyr Cys Phe Leu Pro Leu Asp Leu
                165                 170                 175     
Val Ala Lys Tyr Pro Ser Leu Val Thr Glu Asp Asn Leu Leu Trp Leu
            180                 185                 190         
Ala Glu Thr Val Ala Leu Ile Glu Cys Glu Cys Ser Glu Phe Arg Phe
        195                 200                 205             
Ile Gly Asp Cys Ser Val Arg Val Asn Phe Leu Arg Ser Gln Lys Ile
    210                 215                 220                 
Leu Leu Pro Asp Asn Phe Ser Asn Ile Asp Val Leu Glu Ala Glu Val
225                 230                 235                 240 
Glu Ile Leu Glu Ile Pro Ala Leu Thr Glu Ala Val Arg Trp Tyr Arg
                245                 250                 255     
Met Asn Met Gly Gly Cys Ser Pro Thr Thr Cys Ser Pro Leu Ser Pro
            260                 265                 270         
Gly Lys Gly Ala Arg Thr Ala Ser Leu Glu Ser Val Lys Pro Leu Tyr
        275                 280                 285             
Thr Met Ala Leu Gly Leu Leu Val Lys Tyr Pro Asp Ser Ala Leu Gly
    290                 295                 300                 
Gln Leu Arg Ile Glu Ser Thr Leu Asp Gly Ser Arg Leu Tyr Ile Thr
305                 310                 315                 320 
Gly Asn Gly Val Leu Phe Gln His Val Lys Asn Trp Leu Gly Thr Cys
                325                 330                 335     
Arg Leu Pro Leu Thr Glu Thr Ile Ser Glu Val Tyr Glu Leu Cys Ala
            340                 345                 350         
Phe Leu Asp Lys Arg Asp Ile Thr Tyr Glu Pro Ile Lys Val Ala Leu
        355                 360                 365             
Lys Thr His Leu Glu Pro Arg Thr Leu Ala Pro Met Asp Val Leu Asn
    370                 375                 380                 
Glu Trp Thr Ala Glu Ile Thr Val Tyr Ser Pro Gln Gln Ile Ile Lys
385                 390                 395                 400 
Val Tyr Val Gly Ser His Trp Tyr Ala Thr Thr Leu Gln Thr Leu Leu
                405                 410                 415     
Lys Tyr Pro Glu Leu Leu Ser Asn Pro Gln Arg Val Tyr Trp Ile Thr
            420                 425                 430         
Tyr Gly Gln Thr Leu Leu Ile His Gly Asp Gly Gln Met Phe Arg His
        435                 440                 445             
Ile Leu Asn Phe Leu Arg Leu Gly Lys Leu Phe Leu Pro Ser Glu Phe
    450                 455                 460                 
Lys Glu Trp Pro Leu Phe Cys Gln Glu Val Glu Glu Tyr His Ile Pro
465                 470                 475                 480 
Ser Leu Ser Glu Ala Leu Ala Gln Cys Glu Ala Tyr Lys Ser Trp Thr
                485                 490                 495     
Gln Glu Lys Glu Ser Glu Asn Glu Glu Ala Phe Ser Ile Arg Arg Leu
            500                 505                 510         
His Val Val Thr Glu Gly Pro Gly Ser Leu Val Glu Phe Ser Arg Asp
        515                 520                 525             
Thr Lys Glu Thr Thr Ala Tyr Met Pro Val Asp Phe Glu Asp Cys Ser
    530                 535                 540                 
Asp Arg Thr Pro Trp Asn Lys Ala Lys Gly Asn Leu Val Arg Ser Asn
545                 550                 555                 560 
Gln Met Asp Glu Ala Glu Gln Tyr Thr Arg Pro Ile Gln Val Ser Leu
                565                 570                 575     
Cys Arg Asn Ala Lys Arg Ala Gly Asn Pro Ser Thr Tyr Ser His Cys
            580                 585                 590         
Arg Gly Leu Cys Thr Asn Pro Gly His Trp Gly Ser His Pro Glu Ser
        595                 600                 605             
Pro Pro Lys Lys Lys Cys Thr Thr Ile Asn Leu Thr Gln Lys Ser Glu
    610                 615                 620                 
Thr Lys Asp Pro Pro Ala Thr Pro Met Gln Lys Leu Ile Ser Leu Val
625                 630                 635                 640 
Arg Glu Trp Asp Met Val Asn Cys Lys Gln Trp Glu Phe Gln Pro Leu
                645                 650                 655     
Thr Ala Thr Arg Ser Ser Pro Leu Glu Glu Ala Thr Leu Gln Leu Pro
            660                 665                 670         
Leu Gly Ser Glu Ala Ala Ser Gln Pro Ser Thr Ser Ala Ala Trp Lys
        675                 680                 685             
Ala His Ser Thr Ala Ser Glu Lys Asp Pro Gly Pro Gln Ala Gly Ala
    690                 695                 700                 
Gly Ala Gly Ala Lys Asp Lys Gly Pro Glu Pro Thr Phe Lys Pro Tyr
705                 710                 715                 720 
Leu Pro Pro Lys Arg Ala Gly Thr Leu Lys Asp Trp Ser Lys Gln Arg
                725                 730                 735     
Thr Lys Glu Arg Glu Ser Pro Ala Pro Glu Gln Pro Leu Pro Glu Ala
            740                 745                 750         
Ser Glu Val Asp Ser Leu Gly Val Ile Leu Lys Val Thr His Pro Pro
        755                 760                 765             
Val Val Gly Ser Asp Gly Phe Cys Met Phe Phe Glu Asp Ser Ile Ile
    770                 775                 780                 
Tyr Thr Thr Glu Met Asp Asn Leu Arg His Thr Thr Pro Thr Ala Ser
785                 790                 795                 800 
Pro Gln Pro Gln Glu Val Thr Phe Leu Ser Phe Ser Leu Ser Trp Glu
                805                 810                 815     
Glu Met Phe Tyr Ala Gln Lys Cys His Cys Phe Leu Ala Asp Ile Ile
            820                 825                 830         
Met Asp Ser Ile Arg Gln Lys Asp Pro Lys Ala Ile Thr Ala Lys Val
        835                 840                 845             
Val Ser Leu Ala Asn Arg Leu Trp Thr Leu His Ile Ser Pro Lys Gln
    850                 855                 860                 
Phe Val Val Asp Leu Leu Ala Ile Thr Gly Phe Lys Asp Asp Arg His
865                 870                 875                 880 
Thr Gln Glu Arg Leu Tyr Ser Trp Val Glu Leu Thr Leu Pro Phe Ala
                885                 890                 895     
Arg Lys Tyr Gly Arg Cys Met Asp Leu Leu Ile Gln Arg Gly Leu Ser
            900                 905                 910         
Arg Ser Val Ser Tyr Ser Ile Leu Gly Lys Tyr Leu Gln Glu Asp
        915                 920                 925         


<210> 2939
<211> 313
<212> PRT
<213> Homo sapiens

<400> 2939
Met Thr Val Glu Asn Cys Ser Thr Pro Thr Gln Thr Leu Ala Pro Asp
 1               5                  10                  15      
Thr Tyr Met His Ile Thr Glu Leu Ser Val Ser Leu Ser Gly Thr His
            20                  25                  30          
Leu Gly Pro Leu Trp Leu Gln Lys Arg Glu Leu Lys Leu Arg Lys Val
        35                  40                  45              
Lys Met Phe Ala Asn Asp Ser Lys Gly His Thr Ser Glu Arg Asn Ala
    50                  55                  60                  
Tyr Gly Tyr Lys Gln Arg Lys Tyr Phe Leu Asn Asn Leu Ile Arg Asn
65                  70                  75                  80  
Gln Lys Ala Gly Asn Pro Met Val Gly Pro Val Ile Gln Gln Val Ser
                85                  90                  95      
Arg Leu Leu Gly Asn Lys Lys Pro Glu His Lys Glu Ile Leu Val Glu
            100                 105                 110         
Arg Thr Val Val Thr Val Met Met Thr Val Ala Val Lys Val Gly Val
        115                 120                 125             
Leu Phe Gly Glu Asp Ser Gly Arg Ser Leu Ser Asp Cys Ser Gln Trp
    130                 135                 140                 
Val Glu Asn Ala Leu Asn Val Ala Ile Pro Pro Ala Ser Ile Ala Leu
145                 150                 155                 160 
Pro Pro His Leu Leu Leu Ser Ser Asp Lys Leu Asp Leu Pro Gly Val
                165                 170                 175     
Cys Ile Asp Ile Ala Lys Ala Val Asn Gln Pro Pro Ala Ile Trp Tyr
            180                 185                 190         
Ser Arg Asp Lys Pro Glu Asp Ser Arg Lys Val Met Lys Val Met Met
        195                 200                 205             
Ala Ala Thr Thr Met Asp Lys Thr Cys Lys Glu Pro Trp Trp Ser Arg
    210                 215                 220                 
Ser His Arg Lys Thr Tyr Ala Ile Ile Lys Ala Phe Glu Leu Lys Ser
225                 230                 235                 240 
Tyr Cys Lys Asn Gln Asp Val Ser Ser Asn Gly Ile Cys Leu His Ile
                245                 250                 255     
Phe Ile Asp Gln Thr Glu Ser Phe Tyr Ser Val Ala Pro Thr Ala Gly
            260                 265                 270         
Arg Arg Ile Thr Phe Ile Asn His Val Lys Met Asn Ala Ala Val Met
        275                 280                 285             
Cys Tyr Gln Glu Glu Thr Val Arg Ser Leu Arg Thr Gly Thr Met Tyr
    290                 295                 300                 
Ser Pro Val Glu Leu Pro Tyr Ser Leu
305                 310             


<210> 2940
<211> 425
<212> PRT
<213> Homo sapiens

<400> 2940
Met Ala Ala Val Ser Pro Thr Thr Arg Cys Gln Glu Ser Val Thr Phe
 1               5                  10                  15      
Glu Asp Val Ala Val Val Phe Thr Asp Glu Glu Trp Ser Arg Leu Val
            20                  25                  30          
Pro Ile Gln Arg Asp Leu Tyr Lys Glu Val Met Leu Glu Asn Tyr Asn
        35                  40                  45              
Ser Ile Val Ser Leu Gly Leu Pro Val Pro Gln Pro Asp Val Ile Phe
    50                  55                  60                  
Gln Leu Lys Arg Gly Asp Lys Pro Trp Met Val Asp Leu His Gly Ser
65                  70                  75                  80  
Glu Glu Arg Glu Trp Pro Glu Ser Val Ser Leu Asp Trp Glu Thr Lys
                85                  90                  95      
Pro Glu Ile His Asp Ala Ser Asp Lys Lys Ser Glu Gly Ser Leu Arg
            100                 105                 110         
Glu Cys Leu Gly Arg Gln Ser Pro Leu Cys Pro Lys Phe Glu Val His
        115                 120                 125             
Thr Pro Asn Gly Arg Met Gly Thr Glu Lys Gln Ser Pro Ser Gly Glu
    130                 135                 140                 
Thr Arg Lys Lys Ser Leu Ser Arg Asp Lys Gly Leu Arg Arg Arg Ser
145                 150                 155                 160 
Ala Leu Ser Arg Glu Ile Leu Thr Lys Glu Arg His Gln Glu Cys Ser
                165                 170                 175     
Asp Cys Gly Lys Thr Phe Phe Asp His Ser Ser Leu Thr Arg His Gln
            180                 185                 190         
Arg Thr His Thr Gly Glu Lys Pro Tyr Asp Cys Arg Glu Cys Gly Lys
        195                 200                 205             
Ala Phe Ser His Arg Ser Ser Leu Ser Arg His Leu Met Ser His Thr
    210                 215                 220                 
Gly Glu Ser Pro Tyr Glu Cys Ser Val Cys Ser Lys Ala Phe Phe Asp
225                 230                 235                 240 
Arg Ser Ser Leu Thr Val His Gln Arg Ile His Thr Gly Glu Lys Pro
                245                 250                 255     
Phe Gln Cys Asn Glu Cys Gly Lys Ala Phe Phe Asp Arg Ser Ser Leu
            260                 265                 270         
Thr Arg His Gln Arg Ile His Thr Gly Glu Ser Pro Tyr Glu Cys His
        275                 280                 285             
Gln Cys Gly Lys Ala Phe Ser Gln Lys Ser Ile Leu Thr Arg His Gln
    290                 295                 300                 
Leu Ile His Thr Gly Arg Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys
305                 310                 315                 320 
Ala Phe Tyr Gly Val Ser Ser Leu Asn Arg His Gln Lys Ala His Ala
                325                 330                 335     
Gly Asp Pro Arg Tyr Gln Cys Asn Glu Cys Gly Lys Ala Phe Phe Asp
            340                 345                 350         
Arg Ser Ser Leu Thr Gln His Gln Lys Ile His Thr Gly Asp Lys Pro
        355                 360                 365             
Tyr Glu Cys Ser Glu Cys Gly Lys Ala Phe Ser Gln Arg Cys Arg Leu
    370                 375                 380                 
Thr Arg His Gln Arg Val His Thr Gly Glu Lys Pro Phe Glu Cys Thr
385                 390                 395                 400 
Val Cys Gly Lys Val Phe Ser Ser Lys Ser Ser Val Ile Gln His Gln
                405                 410                 415     
Arg Arg Tyr Ala Lys Gln Gly Ile Asp
            420                 425 


<210> 2941
<211> 243
<212> PRT
<213> Homo sapiens

<400> 2941
Met Ile Thr Pro His Gln Gly Gly Gly Lys Gly Gln Ser Phe His Ser
 1               5                  10                  15      
Ala His Pro Asp Asn Asn His Pro Leu Lys Pro Gln Asn Lys Gly Pro
            20                  25                  30          
Leu Ala Ser Ser Thr Ile His Leu Glu Gly Thr Gly Gly Leu Lys Gln
        35                  40                  45              
Gly Ala Ser Ile Ser Pro Val Asn Gln Ala Tyr Tyr Ser Pro Gly Trp
    50                  55                  60                  
Cys Ile Ala Ala Val Ala Tyr Met Ala Thr Val Ser Arg Gln Leu Val
65                  70                  75                  80  
Gln Asn Leu His Phe Val Pro Thr Leu Asn Ile Asn Ser Pro Lys Ala
                85                  90                  95      
Phe Ser Gly Trp Arg Phe Leu Leu Ser Ser Pro Thr Arg Ala Phe Asp
            100                 105                 110         
Ser Asn Ser Ala Leu Gln Pro Glu Ala Gly Gly Arg Lys Pro Gly Ala
        115                 120                 125             
Pro Gly Arg Gln Pro Asn Trp Trp Ala Arg Arg Ser Pro Arg Gly Ser
    130                 135                 140                 
Arg Ala Arg Ala Cys Pro Ala Thr Glu Glu Pro Glu Leu Leu Arg Asp
145                 150                 155                 160 
Gly Asp Pro Gln Ala Pro Gly Ser Arg Pro Asn Arg Ser Cys Pro Ala
                165                 170                 175     
Pro Glu Pro Thr Cys Arg Thr Trp Ala Ala Ala Arg Pro Gly Ser Gln
            180                 185                 190         
Pro Leu Ala Thr Arg Ala Gly Arg Pro Glu Gly Thr Lys Ala Phe Arg
        195                 200                 205             
Gly Gly Asp Glu Pro Pro Ser Pro Pro Arg Phe Gln Arg Ala Gly Cys
    210                 215                 220                 
Arg Gly Pro Arg Trp Glu Arg Pro Pro Arg Leu Pro Asp Phe Pro Ala
225                 230                 235                 240 
Leu Gly Arg
            


<210> 2942
<211> 896
<212> PRT
<213> Homo sapiens

<400> 2942
Met Arg Phe Thr Val Arg Asp Cys Ser Ser Leu Pro Asn Val Pro Gly
 1               5                  10                  15      
Ser Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Tyr Glu Thr Asp Ser Val
            20                  25                  30          
Ile Ala Thr Lys Lys Ser Ala Phe Trp Ser Glu Ala Pro Tyr Leu Lys
        35                  40                  45              
Val Asp Thr Ile Ala Ala Asp Glu Ser Phe Ser Gln Val Asp Phe Gly
    50                  55                  60                  
Gly Arg Leu Met Lys Val Asn Thr Glu Val Arg Ser Phe Gly Pro Leu
65                  70                  75                  80  
Thr Arg Asn Gly Phe Tyr Leu Ala Phe Gln Asp Tyr Gly Ala Cys Met
                85                  90                  95      
Ser Leu Leu Ser Val Arg Val Phe Phe Lys Lys Cys Pro Ser Ile Val
            100                 105                 110         
Gln Asn Phe Ala Val Phe Pro Glu Thr Met Thr Gly Ala Glu Ser Thr
        115                 120                 125             
Ser Leu Val Ile Ala Arg Gly Thr Cys Ile Pro Asn Ala Glu Glu Val
    130                 135                 140                 
Asp Val Pro Ile Lys Leu Tyr Cys Asn Gly Asp Gly Glu Trp Met Val
145                 150                 155                 160 
Pro Ile Gly Arg Cys Thr Cys Lys Pro Gly Tyr Glu Pro Glu Asn Ser
                165                 170                 175     
Val Ala Cys Lys Ala Cys Pro Ala Gly Thr Phe Lys Ala Ser Gln Glu
            180                 185                 190         
Ala Glu Gly Cys Ser His Cys Pro Ser Asn Ser Arg Ser Pro Ala Glu
        195                 200                 205             
Ala Ser Pro Ile Cys Thr Cys Arg Thr Gly Tyr Tyr Arg Ala Asp Phe
    210                 215                 220                 
Asp Pro Pro Glu Val Ala Cys Thr Ser Val Pro Ser Gly Pro Arg Asn
225                 230                 235                 240 
Val Ile Ser Ile Val Asn Glu Thr Ser Ile Ile Leu Glu Trp His Pro
                245                 250                 255     
Pro Arg Glu Thr Gly Gly Arg Asp Asp Val Thr Tyr Asn Ile Ile Cys
            260                 265                 270         
Lys Lys Cys Arg Ala Asp Arg Arg Ser Cys Ser Arg Cys Asp Asp Asn
        275                 280                 285             
Val Glu Phe Val Pro Arg Gln Leu Gly Leu Thr Glu Cys Arg Val Ser
    290                 295                 300                 
Ile Ser Ser Leu Trp Ala His Thr Pro Tyr Thr Phe Asp Ile Gln Ala
305                 310                 315                 320 
Ile Asn Gly Val Ser Ser Lys Ser Pro Phe Pro Pro Gln His Val Ser
                325                 330                 335     
Val Asn Ile Thr Thr Asn Gln Ala Ala Pro Ser Thr Val Pro Ile Met
            340                 345                 350         
His Gln Val Ser Ala Thr Met Arg Ser Ile Thr Leu Ser Trp Pro Gln
        355                 360                 365             
Pro Glu Gln Pro Asn Gly Ile Ile Leu Asp Tyr Glu Ile Arg Tyr Tyr
    370                 375                 380                 
Glu Lys Glu His Asn Glu Phe Asn Ser Ser Met Ala Arg Ser Gln Thr
385                 390                 395                 400 
Asn Thr Ala Arg Ile Asp Gly Leu Arg Pro Gly Met Val Tyr Val Val
                405                 410                 415     
Gln Val Arg Ala Arg Thr Val Ala Gly Tyr Gly Lys Phe Ser Gly Lys
            420                 425                 430         
Met Cys Phe Gln Thr Leu Thr Asp Asp Asp Tyr Lys Ser Glu Leu Arg
        435                 440                 445             
Glu Gln Leu Pro Leu Ile Ala Gly Ser Ala Ala Ala Gly Val Val Phe
    450                 455                 460                 
Val Val Ser Leu Val Ala Ile Ser Ile Val Cys Ser Arg Lys Arg Ala
465                 470                 475                 480 
Tyr Ser Lys Glu Ala Val Tyr Ser Asp Lys Leu Gln His Tyr Ser Thr
                485                 490                 495     
Gly Arg Gly Ser Pro Gly Met Lys Ile Tyr Ile Asp Pro Phe Thr Tyr
            500                 505                 510         
Glu Asp Pro Asn Glu Ala Val Arg Glu Phe Ala Lys Glu Ile Asp Val
        515                 520                 525             
Ser Phe Val Lys Ile Glu Glu Val Ile Gly Ala Gly Glu Phe Gly Glu
    530                 535                 540                 
Val Tyr Lys Gly Arg Leu Lys Leu Pro Gly Lys Arg Glu Ile Tyr Val
545                 550                 555                 560 
Ala Ile Lys Thr Leu Lys Ala Gly Tyr Ser Glu Lys Gln Arg Arg Asp
                565                 570                 575     
Phe Leu Ser Glu Ala Ser Ile Met Gly Gln Phe Asp His Pro Asn Ile
            580                 585                 590         
Ile Arg Leu Glu Gly Val Val Thr Lys Ser Arg Pro Val Met Ile Ile
        595                 600                 605             
Thr Glu Phe Met Glu Asn Gly Ala Leu Asp Ser Phe Leu Arg Gln Asn
    610                 615                 620                 
Asp Gly Gln Phe Thr Val Ile Gln Leu Val Gly Met Leu Arg Gly Ile
625                 630                 635                 640 
Ala Ala Gly Met Lys Tyr Leu Ala Glu Met Asn Tyr Val His Arg Asp
                645                 650                 655     
Leu Ala Ala Arg Asn Ile Leu Val Asn Ser Asn Leu Val Cys Lys Val
            660                 665                 670         
Ser Asp Phe Gly Leu Ser Arg Tyr Leu Gln Asp Asp Thr Ser Asp Pro
        675                 680                 685             
Thr Tyr Thr Ser Ser Leu Gly Gly Lys Ile Pro Val Arg Trp Thr Ala
    690                 695                 700                 
Pro Glu Ala Ile Ala Tyr Arg Lys Phe Thr Ser Ala Ser Asp Val Trp
705                 710                 715                 720 
Ser Tyr Gly Ile Val Met Trp Glu Val Met Ser Phe Gly Glu Arg Pro
                725                 730                 735     
Tyr Trp Asp Met Ser Asn Gln Asp Val Ile Asn Ala Ile Glu Gln Asp
            740                 745                 750         
Tyr Arg Leu Pro Pro Pro Met Asp Cys Pro Ala Ala Leu His Gln Leu
        755                 760                 765             
Met Leu Asp Cys Trp Gln Lys Asp Arg Asn Ser Arg Pro Arg Phe Ala
    770                 775                 780                 
Glu Ile Val Asn Thr Leu Asp Lys Met Ile Arg Asn Pro Ala Ser Leu
785                 790                 795                 800 
Lys Thr Val Ala Thr Ile Thr Ala Val Pro Ser Gln Pro Leu Leu Asp
                805                 810                 815     
Arg Ser Ile Pro Asp Phe Thr Ala Phe Thr Thr Val Asp Asp Trp Leu
            820                 825                 830         
Ser Ala Ile Lys Met Val Gln Tyr Arg Asp Ser Phe Leu Thr Ala Gly
        835                 840                 845             
Phe Thr Ser Leu Gln Leu Val Thr Gln Met Thr Ser Glu Asp Leu Leu
    850                 855                 860                 
Arg Ile Gly Ile Thr Leu Ala Gly His Gln Lys Lys Ile Leu Asn Ser
865                 870                 875                 880 
Ile His Ser Met Arg Val Gln Ile Ser Gln Ser Pro Thr Ala Met Ala
                885                 890                 895     


<210> 2943
<211> 922
<212> PRT
<213> Homo sapiens

<400> 2943
Met Leu Lys His Leu Gln Val Leu Asp Leu His Gln Cys Ser Leu Thr
 1               5                  10                  15      
Ala Asp Asp Val Met Ser Leu Thr Gln Val Ile Pro Leu Leu Ser Asn
            20                  25                  30          
Leu Gln Glu Leu Asp Leu Ser Ala Asn Lys Lys Met Gly Ser Ser Ser
        35                  40                  45              
Glu Asn Leu Leu Ser Arg Leu Arg Phe Leu Pro Ala Leu Lys Ser Leu
    50                  55                  60                  
Val Ile Asn Asn Cys Ala Leu Glu Ser Glu Thr Phe Thr Ala Leu Ala
65                  70                  75                  80  
Glu Ala Ser Val His Leu Ser Ala Leu Glu Val Phe Asn Leu Ser Trp
                85                  90                  95      
Asn Lys Cys Val Gly Gly Asn Leu Lys Leu Leu Leu Glu Thr Leu Lys
            100                 105                 110         
Leu Ser Met Ser Leu Gln Val Leu Arg Leu Ser Ser Cys Ser Leu Val
        115                 120                 125             
Thr Glu Asp Val Ala Leu Leu Gly Val Tyr Leu Leu Val Pro Lys Arg
    130                 135                 140                 
Ser Trp Gln Thr Glu Gln Trp Val Gln Asn Leu Thr Leu Arg Ser Gln
145                 150                 155                 160 
Lys Leu Gly Val Leu Ser Ser Ser Gln Asn Gly Pro Pro Lys Ser Thr
                165                 170                 175     
Ser Gln Thr Gln Ser Leu Thr Ile Cys His Asn Lys Thr Thr Val Thr
            180                 185                 190         
Ser Ser Lys Ile Ser Gln Arg Asp Pro Ser Pro Glu Ser Asn Lys Lys
        195                 200                 205             
Gly Glu Ser Pro Ser Leu Glu Ser Arg Ser Thr Ala Val Thr Arg Thr
    210                 215                 220                 
Ser Ser Ile His Gln Leu Ile Ala Pro Ala Ser Tyr Ser Pro Ile Gln
225                 230                 235                 240 
Pro His Ser Leu Ile Lys His Gln Gln Ile Pro Leu His Ser Pro Pro
                245                 250                 255     
Ser Lys Val Ser His His Gln Leu Ile Leu Gln Gln Gln Gln Gln Gln
            260                 265                 270         
Ile Gln Pro Ile Thr Leu Gln Asn Ser Thr Gln Asp Pro Pro Pro Ser
        275                 280                 285             
Gln His Cys Ile Pro Leu Gln Asn His Gly Leu Pro Pro Ala Pro Ser
    290                 295                 300                 
Asn Ala Gln Ser Gln His Cys Ser Pro Ile Gln Ser His Pro Ser Pro
305                 310                 315                 320 
Leu Thr Val Ser Pro Asn Gln Ser Gln Ser Ala Gln Gln Ser Val Val
                325                 330                 335     
Val Ser Pro Pro Pro Pro His Ser Pro Ser Gln Ser Pro Thr Ile Ile
            340                 345                 350         
Ile His Pro Gln Ala Leu Ile Gln Pro His Pro Leu Val Ser Ser Ala
        355                 360                 365             
Leu Gln Pro Gly Pro Asn Leu Gln Gln Ser Thr Ala Asn Gln Val Gln
    370                 375                 380                 
Ala Thr Ala Gln Leu Asn Leu Pro Ser His Leu Pro Leu Pro Ala Ser
385                 390                 395                 400 
Pro Val Val His Ile Gly Pro Val Gln Gln Ser Ala Leu Val Ser Pro
                405                 410                 415     
Gly Gln Gln Ile Val Ser Pro Ser His Gln Gln Tyr Ser Ser Leu Gln
            420                 425                 430         
Ser Ser Pro Ile Pro Ile Ala Ser Pro Pro Gln Met Ser Thr Ser Pro
        435                 440                 445             
Pro Ala Gln Ile Pro Pro Leu Pro Leu Gln Ser Met Gln Ser Leu Gln
    450                 455                 460                 
Val Gln Pro Glu Ile Leu Ser Gln Gly Gln Val Leu Val Gln Asn Ala
465                 470                 475                 480 
Leu Val Ser Glu Glu Glu Leu Pro Ala Ala Glu Ala Leu Val Gln Leu
                485                 490                 495     
Pro Phe Gln Thr Leu Pro Pro Pro Gln Thr Val Ala Val Asn Leu Gln
            500                 505                 510         
Val Gln Pro Pro Ala Pro Val Asp Pro Pro Val Val Tyr Gln Val Glu
        515                 520                 525             
Asp Val Cys Glu Glu Glu Met Pro Glu Glu Ser Asp Glu Cys Val Arg
    530                 535                 540                 
Met Asp Arg Thr Pro Pro Pro Pro Thr Leu Ser Pro Ala Ala Ile Thr
545                 550                 555                 560 
Val Gly Arg Gly Glu Asp Leu Thr Ser Glu His Pro Leu Leu Glu Gln
                565                 570                 575     
Val Glu Leu Pro Ala Val Ala Ser Val Ser Ala Ser Val Ile Lys Ser
            580                 585                 590         
Pro Ser Asp Pro Ser His Val Ser Val Pro Pro Pro Pro Leu Leu Leu
        595                 600                 605             
Pro Ala Ala Thr Thr Arg Ser Asn Ser Thr Ser Met His Ser Ser Ile
    610                 615                 620                 
Pro Ser Ile Glu Asn Lys Pro Pro Gln Ala Ile Val Lys Pro Gln Ile
625                 630                 635                 640 
Leu Thr His Val Ile Glu Gly Phe Val Ile Gln Glu Gly Leu Glu Pro
                645                 650                 655     
Phe Pro Val Ser Arg Ser Ser Leu Leu Ile Glu Gln Pro Val Lys Lys
            660                 665                 670         
Arg Pro Leu Leu Asp Asn Gln Val Ile Asn Ser Val Cys Val Gln Pro
        675                 680                 685             
Glu Leu Gln Asn Asn Thr Lys His Ala Asp Asn Ser Ser Asp Thr Glu
    690                 695                 700                 
Met Glu Asp Met Ile Ala Glu Glu Thr Leu Glu Glu Met Asp Ser Glu
705                 710                 715                 720 
Leu Leu Lys Cys Glu Phe Cys Gly Lys Met Gly Tyr Ala Asn Glu Phe
                725                 730                 735     
Leu Arg Ser Lys Arg Phe Cys Thr Met Ser Cys Ala Lys Arg Tyr Asn
            740                 745                 750         
Val Ser Cys Ser Lys Lys Phe Ala Leu Ser Arg Trp Asn Arg Lys Pro
        755                 760                 765             
Asp Asn Gln Ser Leu Gly His Arg Gly Arg Arg Pro Ser Gly Pro Asp
    770                 775                 780                 
Gly Ala Ala Arg Glu His Ile Leu Arg Gln Leu Pro Ile Thr Tyr Pro
785                 790                 795                 800 
Ser Ala Glu Glu Asp Leu Ala Ser His Glu Asp Ser Val Pro Ser Ala
                805                 810                 815     
Met Thr Thr Arg Leu Arg Arg Gln Ser Glu Arg Glu Arg Glu Arg Glu
            820                 825                 830         
Leu Arg Asp Val Arg Ile Arg Lys Met Pro Glu Asn Ser Asp Leu Leu
        835                 840                 845             
Pro Val Ala Gln Thr Glu Pro Ser Ile Trp Thr Val Asp Asp Val Trp
    850                 855                 860                 
Ala Phe Ile His Ser Leu Pro Gly Cys Gln Asp Ile Ala Asp Glu Phe
865                 870                 875                 880 
Arg Ala Gln Glu Ile Asp Gly Gln Ala Leu Leu Leu Leu Lys Glu Asp
                885                 890                 895     
His Leu Met Ser Ala Met Asn Ile Lys Leu Gly Pro Ala Leu Lys Ile
            900                 905                 910         
Cys Ala Arg Ile Asn Ser Leu Lys Glu Ser
        915                 920         


<210> 2944
<211> 311
<212> PRT
<213> Homo sapiens

<400> 2944
Met Asp Glu Gly Gly Pro Leu Asn Ala Glu Val Pro Val Lys His Ser
 1               5                  10                  15      
Pro Glu Glu Phe Ser Leu Ser Arg Arg Pro Ser Ser Pro Pro Pro Ala
            20                  25                  30          
Ser Pro Ser Pro Gly Phe Gln Phe Gly Ser Cys Asp Ser Asn Ser Asp
        35                  40                  45              
Phe Ala Pro His Pro Tyr Ser Pro Ser Leu Pro Ser Pro Ser Pro Pro
    50                  55                  60                  
Ser His Arg Leu His Ser Asn Arg Gln Thr Trp Arg Trp His Gln Tyr
65                  70                  75                  80  
Arg Asp Thr Gly Ser Gly Ser Pro Gly Val Val Glu Arg Cys Val Pro
                85                  90                  95      
Ser Glu Lys Asp Pro Ala Gln Phe Arg Asp Pro Gly Ala Leu Ala Gln
            100                 105                 110         
Ala Leu Val Val Gln Leu Gly His Arg Arg Ile Ala His Asp Leu Arg
        115                 120                 125             
Leu Leu Leu Leu Gln His Leu Trp Leu Gly Arg Thr Gly Gln Ala Pro
    130                 135                 140                 
Val Val Glu Tyr Pro Ile Cys Leu Val Cys Leu Arg Pro Arg Ser Pro
145                 150                 155                 160 
Ser Cys Pro Leu Pro Arg Tyr Arg Thr Gly Pro Arg Leu Leu Ala Phe
                165                 170                 175     
Pro Gln Leu Leu Pro Cys Val Gln Gly Gln Glu Ser Gly Pro Leu Arg
            180                 185                 190         
Ile Gly Ile Gly Phe Gly Leu Arg Leu Pro Gln Gly Gln Ala Arg Ala
        195                 200                 205             
Leu His Leu Leu Pro Glu Lys Arg Pro Lys Glu Ala Gly Pro Gln Gly
    210                 215                 220                 
Lys Ala Thr Gln Ala Cys Gly His Gln Leu Pro Ala Ser Gln Pro Pro
225                 230                 235                 240 
Ala Ala Gln Ala Arg Ala Asp Pro Val Pro Gly Thr Pro Ser Gln Thr
                245                 250                 255     
Arg Ser Phe Arg Ser Ala Gly Leu Gln Ser Pro Asn Ser Pro Arg Cys
            260                 265                 270         
Phe Ser Gly Pro Pro Pro Arg Ala Pro Lys Gln Val Thr Thr Ser Leu
        275                 280                 285             
Lys Pro Arg Pro Cys Pro Gly Pro Lys Arg Pro Val Ser Leu Glu Leu
    290                 295                 300                 
Ile Leu Gln Lys Ser Ser Val
305                 310     


<210> 2945
<211> 221
<212> PRT
<213> Homo sapiens

<400> 2945
Met Ser Asp Phe Lys Gly Met Tyr Gln Val Ile Gln Gly Ile Ile Ser
 1               5                  10                  15      
Pro Val Asn Asp Thr Tyr Gly Lys Lys Asp Leu Ala Ala Ser His His
            20                  25                  30          
Arg Val Ala Met Ala Arg Leu Ala Leu Gln Thr Ser Asp Trp Ile Arg
        35                  40                  45              
Val Asp Pro Trp Glu Ser Glu Gln Ala Gln Trp Met Glu Thr Val Lys
    50                  55                  60                  
Val Leu Arg His His His Ser Lys Leu Leu Arg Ser Pro Pro Gln Met
65                  70                  75                  80  
Glu Gly Pro Asp His Gly Lys Ala Leu Phe Ser Thr Pro Ala Ala Val
                85                  90                  95      
Pro Glu Leu Lys Leu Leu Cys Gly Ala Asp Val Leu Lys Thr Phe Gln
            100                 105                 110         
Thr Pro Asn Leu Trp Lys Asp Ala His Ile Gln Glu Ile Val Glu Lys
        115                 120                 125             
Phe Gly Leu Val Cys Val Gly Arg Val Gly His Asp Pro Lys Gly Tyr
    130                 135                 140                 
Ile Ala Glu Ser Pro Ile Leu Arg Met His Gln His Asn Ile His Leu
145                 150                 155                 160 
Ala Lys Glu Pro Val Gln Asn Glu Ile Ser Ala Thr Tyr Ile Arg Arg
                165                 170                 175     
Ala Leu Gly Gln Gly Gln Ser Val Lys Tyr Leu Ile Pro Asp Ala Val
            180                 185                 190         
Ile Thr Tyr Ile Lys Asp His Gly Leu Tyr Thr Lys Gly Ser Thr Trp
        195                 200                 205             
Lys Gly Lys Ser Thr Gln Ser Thr Glu Gly Lys Thr Ser
    210                 215                 220     


<210> 2946
<211> 109
<212> PRT
<213> Homo sapiens

<400> 2946
Met Trp Lys Ala Glu Glu Lys Thr Gln Leu Ser Leu Glu Gly Ile Gly
 1               5                  10                  15      
Ile Asp Ser Phe Val Glu Glu Gly Trp Leu Ala Glu Asp Pro Tyr Thr
            20                  25                  30          
Asp Lys Glu Gly Val Asp Val Pro Asp Lys Met Lys Ser Arg Ile Pro
        35                  40                  45              
Val Val Leu Leu Ala Cys Gly Ser Phe Asn Pro Ile Thr Asn Met His
    50                  55                  60                  
Leu Arg Met Phe Glu Val Ala Arg Asp His Leu His Gln Thr Gly Gln
65                  70                  75                  80  
Ser Gly Gly Pro Glu Ser Asn Arg Arg Thr Gly Gly Cys His Cys Thr
                85                  90                  95      
Leu Gln Thr Leu Ala Ile Pro Leu Ser Met Val Thr Ala
            100                 105                 


<210> 2947
<211> 317
<212> PRT
<213> Homo sapiens

<400> 2947
Met Ala Thr Ile Cys Val Cys Cys Leu Val Val Phe Ala Ala Ala Arg
 1               5                  10                  15      
Arg Ala Leu Glu Glu Glu Gln Ser Val Val Val Ser Pro Cys Cys Gly
            20                  25                  30          
Leu Gly His Trp Gly Gly Gly Met Leu Ser Arg Val Pro Thr Met Gln
        35                  40                  45              
Pro Leu His His Leu Gln Lys Lys Pro Val Lys Asp Cys Gln Glu Gln
    50                  55                  60                  
Gln Ala Met Lys Trp Ala Leu Pro Arg Ala Tyr Gln Ile Gly Arg Leu
65                  70                  75                  80  
Phe Trp Ala Pro Gly Ser Gly Ala Gly Asp Arg Lys Arg Met Arg Lys
                85                  90                  95      
Glu Gly Gln Arg Lys Gly Glu Arg Arg Val Lys Glu Arg Ala Arg Ile
            100                 105                 110         
Gly Glu Asn Glu Ala Arg Pro Ile Arg Ile Phe Gln Leu Phe Leu Ala
        115                 120                 125             
Ala Pro Cys Gly Trp Arg Lys Glu Ile Leu Cys Thr Lys Thr Gly Arg
    130                 135                 140                 
Gln Arg Cys Ser Cys Gly Lys Asp Lys Ala His Ser Gly Ala Trp Tyr
145                 150                 155                 160 
Asp Leu Lys Val Gln Cys Thr Phe Gly Ala Gly His Arg Asn His Ser
                165                 170                 175     
Arg Gly Ser Ile Thr Leu Ala Ser Leu Ile Ser Ser Lys Ser Ile Gly
            180                 185                 190         
Thr Gln Asp Glu Glu Leu Gly Lys Ser Ser Phe Thr Lys Ala Gly Gln
        195                 200                 205             
Val Gly Lys Trp Gly Gln Glu Ala Gly Leu Ala Ser Ala Tyr Lys Ser
    210                 215                 220                 
Pro Gly His Val Thr Ile Arg Glu Ala Ser Phe Ile Leu Ile Arg Asn
225                 230                 235                 240 
Cys Pro Cys Pro Val Phe Trp Gly Leu Glu Ile Phe Gln Arg Val His
                245                 250                 255     
Gln Glu Gln Pro Ile Ser Pro Lys Lys Arg Gln Ser Cys Val Cys Arg
            260                 265                 270         
Gln Ser Lys Gly Glu Ala Arg Asp Met Leu Arg Phe Gly Gly Ala Gln
        275                 280                 285             
Val Phe Glu Val Asn Val Pro Met Thr Arg Arg Arg Trp Pro Ser Glu
    290                 295                 300                 
Lys Ser Gly Ala Gln Pro Glu Pro Glu Val Ser Asp Ser
305                 310                 315         


<210> 2948
<211> 814
<212> PRT
<213> Homo sapiens

<400> 2948
Met Ala Pro Gly Cys Glu His Glu Lys His Met Gln Gly Trp Leu Asn
 1               5                  10                  15      
Pro Gly Leu Gly Val Gly Gln Ser Tyr Lys Val Gly Glu Arg Cys Pro
            20                  25                  30          
Ser Ser Trp Gln Thr Arg Gly Gly Glu Glu Glu Arg Gly Pro Glu Arg
        35                  40                  45              
Trp Thr Arg Cys Cys Arg Glu Trp Lys Ala Arg Pro Ile Ala Asn Ile
    50                  55                  60                  
Arg Gly Ser Gly Ala Gly Tyr Phe Leu Arg Pro Gly Gly Gln Val Ala
65                  70                  75                  80  
Arg Glu Thr Arg Gly Cys Glu Val Arg Ala Ala Gln His Ala Ala Ala
                85                  90                  95      
Arg Asn Glu Pro Lys Arg Pro Pro Gly Asn Asp Thr Trp Pro Lys Phe
            100                 105                 110         
Ser Leu Ala Leu Val Gln Ser His Val Arg Ile Thr Ser Phe Arg Val
        115                 120                 125             
Lys Thr Ser Met Asn Gln Pro Pro Ile Thr His Cys Ala Pro Gln Lys
    130                 135                 140                 
Ala Gln Glu Arg Ser Ser Ser Leu Gln Pro Ser Ala Ser Ser Val Trp
145                 150                 155                 160 
Gly Glu Glu Leu Leu Ala Val Ser Arg Ser Ala Thr Pro Pro Ser Pro
                165                 170                 175     
Arg Val Gln Pro Val Thr Phe Tyr Tyr Pro Ala Leu Val Gly Glu Glu
            180                 185                 190         
His Leu Ala Arg Val Ser Ala Gly Pro Gly Gly Glu Phe Arg Leu Asp
        195                 200                 205             
Phe Lys Ala Glu Leu Ser Asn Leu Ser Ala Glu Leu Ser Ala Ala Thr
    210                 215                 220                 
Leu Cys Asn Glu His Ala Ala Glu Pro Gly Asp Ala Phe Ala Thr Val
225                 230                 235                 240 
Pro Ser Ala His Lys Pro Phe Gln Val Gln Ser Lys Gly Lys Arg His
                245                 250                 255     
Phe His Asn Gly Gly Arg Ala Leu Ala Gly Arg Lys Val Gln Val Ser
            260                 265                 270         
Glu Val Glu Pro Leu Ser Arg Gln Ala Leu His Glu Cys Leu Phe Val
        275                 280                 285             
Glu Leu Asp Gly Met Thr Leu Tyr Ala Glu His His Ser Arg Val Ile
    290                 295                 300                 
Gln Gly Glu Gly Thr Ile Arg Trp Ala Gln Trp Thr Asp Ile Ala Gly
305                 310                 315                 320 
Arg Gln Thr Cys Glu Glu Leu Lys Gly Lys Lys Gly Arg Val Asp Cys
                325                 330                 335     
Val Ile Met Thr Ser Leu Leu Cys Met His Arg Gly Lys Glu Ser Leu
            340                 345                 350         
Gly Gln Ala Arg Gly Ser Gly Pro Ala Asn Ala Gly Pro Arg Leu Lys
        355                 360                 365             
Tyr Arg His Ser Glu Arg Lys Glu Ala Ala Gln His Ser Pro Val Gly
    370                 375                 380                 
Ser Ile Lys Ser Leu Ile Arg Glu Ser Cys Pro Glu Gly Phe Arg Val
385                 390                 395                 400 
Glu Ile Ala Asp Leu Thr Gly Tyr Phe Lys Leu Asn Lys Glu Met Leu
                405                 410                 415     
Lys Ala Val Arg Ala Val Lys Lys Gly Glu Pro Gly Leu Lys Thr Gly
            420                 425                 430         
Lys Ser His Glu Glu Arg Gly Thr Gln Val Lys Ser Met Gly Lys Leu
        435                 440                 445             
Val Gly His Glu Leu Lys Ser Gly Lys Leu Ser Gln Gly Lys Leu Gly
    450                 455                 460                 
Lys Pro Leu Ala Val Ser Ala Glu Arg Val Gly Val Met Arg Asn Gly
465                 470                 475                 480 
Glu Gln Ile Ala Asp Leu Arg Glu Asn Thr Trp Leu Leu Pro Phe Thr
                485                 490                 495     
Leu Ser Glu Leu Gly His Gln Ser Ala Arg Cys Thr Leu Asp Ser Val
            500                 505                 510         
Val Gly Arg Gln Ser Ala Asn His Gly Glu Gly Lys Ser Ala Asp Met
        515                 520                 525             
Leu Gly Ser Ser His Ser Ala Leu Gly Gly Phe Ala Asn Gly Val Thr
    530                 535                 540                 
Ser Ser Tyr Asn Arg Ile Ala Phe Ser Glu Ser Ile Ser Gln Leu Pro
545                 550                 555                 560 
Phe His Ala Glu Asp Ile Thr Asn Ile Leu Thr Leu Ala Val Tyr Leu
                565                 570                 575     
Arg Thr Gly Gly Thr Lys Ile Cys Gly Val Gln Asp Val Ser His Val
            580                 585                 590         
Thr Gln Pro Lys Lys Ala Leu Arg Pro Ser His Pro Cys Ser Gln Pro
        595                 600                 605             
Gln Asp Gly Gly Thr Gly Arg Lys His Cys Glu Ile Ser Ala Ser Gly
    610                 615                 620                 
Gly Tyr Ala Glu Glu Thr Thr Pro Asn Trp Leu Gln Asn Glu Val Asn
625                 630                 635                 640 
Leu Glu Ile Cys Ser Ile Lys Val Ser Gly Ser Lys Cys Gln Trp Leu
                645                 650                 655     
Ser Ala Arg Ser Ser Glu Phe Pro Arg Ser Ser Val Leu Gln Leu Ser
            660                 665                 670         
Gly Val Leu Thr Pro Thr Phe Lys Ser Phe Gln Val Phe Leu Thr Lys
        675                 680                 685             
Gly His Ala Gly Met Ile Ile Pro Arg Lys Met Gln Phe Arg Glu Val
    690                 695                 700                 
Lys Asp Val Val Tyr Ile Ser Gly Ile Thr Phe Val Ser Cys Met Leu
705                 710                 715                 720 
Leu Pro Asn Asn Ala Thr Leu Gln Thr Cys Arg Asp Val Gly Glu Arg
                725                 730                 735     
Glu Ser Pro Leu Pro Gly Pro Cys Arg Ser Trp Gly Ile Lys Thr Thr
            740                 745                 750         
Asn His His Leu Gln Leu Gln Ile Gln Pro Lys Gln Thr Trp Lys Glu
        755                 760                 765             
Gly Pro Ser Met Glu Gln Asn Gln Ser Pro Asp Ser Lys Gly Tyr Glu
    770                 775                 780                 
Arg Gly Cys Arg Met Arg Ile Glu Asp Lys Gly Leu Ser His Ile Trp
785                 790                 795                 800 
Arg Glu Val Lys Val Lys Asn Asn Val Cys Cys Gln Asn Tyr
                805                 810                 


<210> 2949
<211> 1364
<212> PRT
<213> Homo sapiens

<400> 2949
Met Val Ala Ala Leu Ser Pro Ala Asp Ile Asn Tyr Asp Glu Thr Leu
 1               5                  10                  15      
Ser Thr Leu Arg Tyr Ala Asp Arg Ala Lys Gln Ile Arg Cys Asn Ala
            20                  25                  30          
Val Ile Asn Glu Asp Pro Asn Asn Lys Leu Ile Arg Glu Leu Lys Asp
        35                  40                  45              
Glu Val Thr Arg Leu Arg Asp Leu Leu Tyr Ala Gln Gly Leu Gly Asp
    50                  55                  60                  
Ile Thr Asp Met Thr Asn Ala Leu Val Gly Met Ser Pro Ser Ser Ser
65                  70                  75                  80  
Leu Ser Ala Leu Ser Ser Arg Ala Ala Ser Val Ser Ser Leu His Glu
                85                  90                  95      
Arg Ile Leu Phe Ala Pro Gly Ser Glu Glu Ala Ile Glu Arg Leu Lys
            100                 105                 110         
Glu Thr Glu Lys Ile Ile Ala Glu Leu Asn Glu Thr Trp Glu Glu Lys
        115                 120                 125             
Leu Arg Arg Thr Glu Ala Ile Arg Met Glu Arg Glu Ala Leu Leu Ala
    130                 135                 140                 
Glu Met Gly Val Ala Met Arg Glu Asp Gly Gly Thr Leu Gly Val Phe
145                 150                 155                 160 
Ser Pro Lys Lys Thr Pro His Leu Val Asn Leu Asn Glu Asp Pro Leu
                165                 170                 175     
Met Ser Glu Cys Leu Leu Tyr Tyr Ile Lys Asp Gly Ile Thr Arg Val
            180                 185                 190         
Gly Arg Glu Asp Gly Glu Arg Arg Gln Asp Ile Val Leu Ser Gly His
        195                 200                 205             
Phe Ile Lys Glu Glu His Cys Val Phe Arg Ser Asp Ser Arg Gly Gly
    210                 215                 220                 
Ser Glu Ala Val Val Thr Leu Glu Pro Cys Glu Gly Ala Asp Thr Tyr
225                 230                 235                 240 
Val Asn Gly Lys Lys Val Thr Glu Pro Ser Ile Leu Arg Ser Gly Asn
                245                 250                 255     
Arg Ile Ile Met Gly Lys Ser His Val Phe Arg Phe Asn His Pro Glu
            260                 265                 270         
Gln Ala Arg Gln Glu Arg Glu Arg Thr Pro Cys Ala Glu Thr Pro Ala
        275                 280                 285             
Glu Pro Val Asp Trp Ala Phe Ala Gln Arg Glu Leu Leu Glu Lys Gln
    290                 295                 300                 
Gly Ile Asp Met Lys Gln Glu Met Glu Gln Arg Leu Gln Glu Leu Glu
305                 310                 315                 320 
Asp Gln Tyr Arg Arg Glu Arg Glu Glu Ala Thr Tyr Leu Leu Glu Gln
                325                 330                 335     
Gln Arg Leu Asp Tyr Glu Ser Lys Leu Glu Ala Leu Gln Lys Gln Met
            340                 345                 350         
Asp Ser Arg Tyr Tyr Pro Glu Val Asn Glu Glu Glu Glu Glu Pro Glu
        355                 360                 365             
Asp Glu Val Gln Trp Thr Glu Arg Glu Cys Glu Leu Ala Leu Trp Ala
    370                 375                 380                 
Phe Arg Lys Trp Lys Trp Tyr Gln Phe Thr Ser Leu Arg Asp Leu Leu
385                 390                 395                 400 
Trp Gly Asn Ala Ile Phe Leu Lys Glu Ala Asn Ala Ile Ser Val Glu
                405                 410                 415     
Leu Lys Lys Lys Val Gln Phe Gln Phe Val Leu Leu Thr Asp Thr Leu
            420                 425                 430         
Tyr Ser Pro Leu Pro Pro Asp Leu Leu Pro Pro Glu Ala Ala Lys Asp
        435                 440                 445             
Arg Glu Thr Arg Pro Phe Pro Arg Thr Ile Val Ala Val Glu Val Gln
    450                 455                 460                 
Asp Gln Lys Asn Gly Ala Thr His Tyr Trp Thr Leu Glu Lys Leu Arg
465                 470                 475                 480 
Gln Arg Leu Asp Leu Met Arg Glu Met Tyr Asp Arg Ala Ala Glu Val
                485                 490                 495     
Pro Ser Ser Val Ile Glu Asp Cys Asp Asn Val Val Thr Gly Gly Asp
            500                 505                 510         
Pro Phe Tyr Asp Arg Phe Pro Trp Phe Arg Leu Val Gly Arg Ala Phe
        515                 520                 525             
Val Tyr Leu Ser Asn Leu Leu Tyr Pro Val Pro Leu Val His Arg Val
    530                 535                 540                 
Ala Ile Val Ser Glu Lys Gly Glu Val Lys Gly Phe Leu Arg Val Ala
545                 550                 555                 560 
Val Gln Ala Ile Ser Ala Asp Glu Glu Ala Pro Asp Tyr Gly Ser Gly
                565                 570                 575     
Val Arg Gln Ser Gly Thr Ala Lys Ile Ser Phe Asp Asp Gln His Phe
            580                 585                 590         
Glu Lys Phe Gln Ser Glu Ser Cys Pro Val Val Gly Met Ser Arg Ser
        595                 600                 605             
Gly Thr Ser Gln Glu Glu Leu Arg Ile Val Glu Gly Gln Gly Gln Gly
    610                 615                 620                 
Ala Asp Val Gly Pro Ser Ala Asp Glu Val Asn Asn Asn Thr Cys Ser
625                 630                 635                 640 
Ala Val Pro Pro Glu Gly Leu Leu Leu Asp Ser Ser Glu Lys Ala Ala
                645                 650                 655     
Leu Asp Gly Pro Leu Asp Ala Ala Leu Asp His Leu Arg Leu Gly Asn
            660                 665                 670         
Thr Phe Thr Phe Arg Val Thr Val Leu Gln Ala Ser Ser Ile Ser Ala
        675                 680                 685             
Glu Tyr Ala Asp Ile Phe Cys Gln Phe Asn Phe Ile His Arg His Asp
    690                 695                 700                 
Glu Ala Phe Ser Thr Glu Pro Leu Lys Asn Thr Gly Arg Gly Pro Pro
705                 710                 715                 720 
Leu Gly Phe Tyr His Val Gln Asn Ile Ala Val Glu Val Thr Lys Ser
                725                 730                 735     
Phe Ile Glu Tyr Ile Lys Ser Gln Pro Ile Val Phe Glu Val Phe Gly
            740                 745                 750         
His Tyr Gln Gln His Pro Phe Pro Pro Leu Cys Lys Asp Val Leu Ser
        755                 760                 765             
Pro Leu Arg Pro Ser Arg Arg His Phe Pro Arg Val Met Pro Leu Ser
    770                 775                 780                 
Lys Pro Val Pro Ala Thr Lys Leu Ser Thr Leu Thr Arg Pro Cys Pro
785                 790                 795                 800 
Gly Pro Cys His Cys Lys Tyr Asp Leu Leu Val Tyr Phe Glu Ile Cys
                805                 810                 815     
Glu Leu Glu Ala Asn Gly Asp Tyr Ile Pro Ala Val Val Asp His Arg
            820                 825                 830         
Gly Gly Met Pro Cys Met Gly Thr Phe Leu Leu His Gln Gly Ile Gln
        835                 840                 845             
Arg Arg Ile Thr Val Thr Leu Leu His Glu Thr Gly Ser His Ile Arg
    850                 855                 860                 
Trp Lys Glu Val Arg Glu Leu Val Val Gly Arg Ile Arg Asn Thr Pro
865                 870                 875                 880 
Glu Thr Asp Glu Ser Leu Ile Asp Pro Asn Ile Leu Ser Leu Asn Ile
                885                 890                 895     
Leu Ser Ser Gly Tyr Ile His Pro Ala Gln Asp Asp Arg Thr Phe Tyr
            900                 905                 910         
Gln Phe Glu Ala Ala Trp Asp Ser Ser Met His Asn Ser Leu Leu Leu
        915                 920                 925             
Asn Arg Val Thr Pro Tyr Arg Glu Lys Ile Tyr Met Thr Leu Ser Ala
    930                 935                 940                 
Tyr Ile Glu Met Glu Asn Cys Thr Gln Pro Ala Val Val Thr Lys Asp
945                 950                 955                 960 
Phe Cys Met Val Phe Tyr Ser Arg Asp Ala Lys Leu Pro Ala Ser Arg
                965                 970                 975     
Ser Ile Arg Asn Leu Phe Gly Ser Gly Ser Leu Arg Ala Ser Glu Ser
            980                 985                 990         
Asn Arg Val Thr Gly Val Tyr Glu Leu Ser Leu Cys His Val Ala Asp
        995                 1000                1005            
Ala Gly Ser Pro Gly Met Gln Arg Arg Arg Arg Arg Val Leu Asp Thr
    1010                1015                1020                
Ser Val Ala Tyr Val Arg Gly Glu Glu Asn Leu Ala Gly Trp Arg Pro
1025                1030                1035                1040
Arg Ser Asp Ser Leu Ile Leu Asp His Gln Trp Glu Leu Glu Lys Leu
                1045                1050                1055    
Ser Leu Leu Gln Glu Val Glu Lys Thr Arg His Tyr Leu Leu Leu Arg
            1060                1065                1070        
Glu Lys Leu Glu Thr Ala Gln Arg Pro Val Pro Glu Ala Leu Ser Pro
        1075                1080                1085            
Ala Phe Ser Glu Asp Ser Glu Ser His Gly Ser Ser Ser Ala Ser Ser
    1090                1095                1100                
Pro Leu Ser Ala Glu Gly Arg Pro Ser Pro Leu Glu Ala Pro Asn Glu
1105                1110                1115                1120
Arg Gln Arg Glu Leu Ala Val Lys Cys Leu Arg Leu Leu Thr His Thr
                1125                1130                1135    
Phe Asn Arg Glu Tyr Thr His Ser His Val Cys Val Ser Ala Ser Glu
            1140                1145                1150        
Ser Lys Leu Ser Glu Met Ser Val Thr Leu Leu Arg Asp Pro Ser Met
        1155                1160                1165            
Ser Pro Leu Gly Val Ala Thr Leu Thr Pro Ser Ser Thr Cys Pro Ser
    1170                1175                1180                
Leu Val Glu Gly Arg Tyr Gly Ala Thr Asp Leu Arg Thr Pro Gln Pro
1185                1190                1195                1200
Cys Ser Arg Pro Ala Ser Pro Glu Pro Glu Leu Leu Pro Glu Ala Asp
                1205                1210                1215    
Ser Lys Lys Leu Pro Ser Pro Ala Arg Ala Thr Glu Thr Asp Lys Glu
            1220                1225                1230        
Pro Gln Arg Leu Leu Val Pro Asp Ile Gln Glu Ile Arg Val Ser Pro
        1235                1240                1245            
Ile Val Ser Lys Lys Gly Tyr Leu His Phe Leu Glu Pro His Thr Ser
    1250                1255                1260                
Gly Trp Ala Arg Arg Phe Val Val Val Arg Arg Pro Tyr Ala Tyr Met
1265                1270                1275                1280
Tyr Asn Ser Asp Lys Asp Thr Val Glu Arg Phe Val Leu Asn Leu Ala
                1285                1290                1295    
Thr Ala Gln Val Glu Tyr Ser Glu Asp Gln Gln Ala Met Leu Lys Thr
            1300                1305                1310        
Pro Asn Thr Phe Ala Val Cys Thr Glu His Arg Gly Ile Leu Leu Gln
        1315                1320                1325            
Ala Ala Ser Asp Lys Asp Met His Asp Trp Leu Tyr Ala Phe Asn Pro
    1330                1335                1340                
Leu Leu Ala Gly Thr Ile Arg Ser Lys Leu Ser Arg Arg Arg Ser Ala
1345                1350                1355                1360
Gln Met Arg Val
                


<210> 2950
<211> 675
<212> PRT
<213> Homo sapiens

<400> 2950
Met His Pro Leu Ser His Ser Asp Pro Gly Pro Ala Pro Leu Leu Ser
 1               5                  10                  15      
Ala Ala Leu Arg Ala Trp Lys Arg Ile Phe Trp Arg Gln Ile Leu Leu
            20                  25                  30          
Thr Leu Gly Leu Leu Gly Leu Phe Leu Tyr Gly Leu Pro Lys Phe Arg
        35                  40                  45              
His Leu Glu Ala Leu Ile Pro Met Gly Val Cys Pro Ser Ala Thr Met
    50                  55                  60                  
Ser Gln Leu Arg Asp Asn Phe Thr Gly Ala Leu Arg Pro Trp Ala Arg
65                  70                  75                  80  
Pro Glu Val Leu Thr Cys Thr Pro Trp Gly Ala Pro Ile Ile Trp Asp
                85                  90                  95      
Gly Ser Phe Asp Pro Asp Val Ala Lys Gln Glu Ala Arg Gln Gln Asn
            100                 105                 110         
Leu Thr Ile Gly Leu Thr Ile Phe Ala Val Gly Ser Gly Ile Pro Asp
        115                 120                 125             
Arg Gln Thr Val Gln Val Ile Gln Gln Ala Leu His Arg Gln Pro Ser
    130                 135                 140                 
Thr Ala Ala Gln Tyr Leu Gln Gln Met Tyr Ala Ala Gln Gln Gln His
145                 150                 155                 160 
Leu Met Leu Gln Thr Ala Ala Leu Gln Gln Gln His Leu Ser Ser Ala
                165                 170                 175     
Gln Leu Gln Ser Leu Ala Ala Val Gln Gln Ala Ser Leu Val Ser Asn
            180                 185                 190         
Arg Gln Gly Ser Thr Ser Gly Ser Asn Val Ser Ala Gln Ala Pro Ala
        195                 200                 205             
Gln Ser Ser Ser Ile Asn Leu Ala Ala Ser Pro Ala Ala Ala Gln Leu
    210                 215                 220                 
Leu Asn Arg Ala Gln Ser Val Asn Ser Ala Ala Ala Ser Gly Ile Ala
225                 230                 235                 240 
Gln Gln Ala Val Leu Leu Gly Asn Thr Ser Ser Pro Ala Leu Thr Ala
                245                 250                 255     
Ser Gln Ala Gln Met Tyr Leu Arg Ala Gln Met Leu Ile Phe Thr Pro
            260                 265                 270         
Thr Ala Thr Val Ala Thr Val Gln Pro Glu Leu Gly Thr Gly Ser Pro
        275                 280                 285             
Ala Arg Pro Pro Thr Pro Ala Gln Val Gln Asn Leu Thr Leu Arg Thr
    290                 295                 300                 
Gln Gln Thr Pro Ala Ala Ala Ala Ser Gly Pro Thr Pro Thr Gln Pro
305                 310                 315                 320 
Val Leu Pro Ser Leu Ala Leu Lys Pro Thr Pro Gly Gly Ser Gln Pro
                325                 330                 335     
Leu Pro Thr Pro Ala Gln Ser Arg Asn Thr Ala Gln Ala Ser Pro Ala
            340                 345                 350         
Gly Ala Lys Pro Gly Ile Ala Asp Ser Val Met Glu Pro His Lys Lys
        355                 360                 365             
Gly Asp Gly Asn Ser Ser Val Pro Gly Ser Met Glu Gly Arg Ala Gly
    370                 375                 380                 
Leu Ser Arg Thr Val Pro Ala Val Ala Ala His Pro Leu Ile Ala Pro
385                 390                 395                 400 
Gly Pro Val Thr Pro Ala Leu Pro Leu Gln Cys Pro Thr Ala Asn Leu
                405                 410                 415     
His Lys Pro Gly Gly Ser Gln Gln Cys His Pro Pro Thr Pro Asp Thr
            420                 425                 430         
Gly Pro Gln Asn Gly His Pro Glu Gly Val Pro His Thr Pro Gln Arg
        435                 440                 445             
Arg Phe Gln His Thr Ser Ala Val Ile Leu Gln Leu Gln Pro Ala Ser
    450                 455                 460                 
Pro Val Pro Gln Gln Cys Val Pro Asp Asp Trp Lys Glu Val Ala Pro
465                 470                 475                 480 
Gly Glu Lys Ser Val Pro Glu Thr Arg Ser Gly Pro Ser Pro His Gln
                485                 490                 495     
Gln Ala Ile Val Thr Ala Met Pro Gly Gly Leu Pro Val Pro Thr Ser
            500                 505                 510         
Pro Asn Ile Gln Pro Ser Pro Ala His Glu Lys Pro Ser Thr Glu Gln
        515                 520                 525             
Pro Leu Tyr Ser Ser Ser Leu Trp Gly Pro Ala Val Asp Gly Cys Asp
    530                 535                 540                 
Cys Val His Glu Ala Cys Ala Ala Ala Thr Thr Arg Asp Trp Leu Val
545                 550                 555                 560 
Phe Asp Asn Met Gly Ala Tyr Thr Ala Cys His Ile Thr Tyr Ala Met
                565                 570                 575     
Ser Arg Val Ala Trp Glu Ala Leu Arg Arg Gln Leu Met Ala Ala Glu
            580                 585                 590         
Gln Glu Asp Asp Val Glu Gly Val Cys Lys Pro Leu Ser Cys Gly Trp
        595                 600                 605             
Glu Ile Thr Asp Thr Leu Cys Val Gly Pro Val Phe Thr Pro Ala Ser
    610                 615                 620                 
Ile Ile Ala Arg Gly Leu Val Ser Gln Val Gly Lys Ala Val Arg Val
625                 630                 635                 640 
Lys Gln Thr Pro Gly Gly Arg Phe Cys Phe Phe Gly Gln Cys Leu Leu
                645                 650                 655     
Glu Gln Gly Trp Pro Arg Ser Ile Ala Val Ser Ser Ala Asp Ser Pro
            660                 665                 670         
Gly Ile Pro
        675 


<210> 2951
<211> 554
<212> PRT
<213> Homo sapiens

<400> 2951
Met Ala Gly Ala Ser Val Lys Val Ala Val Arg Val Arg Pro Phe Asn
 1               5                  10                  15      
Ser Arg Glu Met Ser Arg Asp Ser Lys Cys Ile Ile Gln Met Ser Gly
            20                  25                  30          
Ser Thr Thr Thr Gly Gln Phe Val Leu Gly Pro Leu Val Gln Leu Gln
        35                  40                  45              
Leu Leu Leu Pro Ser Gln Asp Gln Val Val Ser Ala Ala Leu Ser Gly
    50                  55                  60                  
Asp Met Asn Ser His Leu Val Phe Arg Met Trp Thr Met Thr Ala Phe
65                  70                  75                  80  
Pro Phe Thr Gly Ala Val His Pro Ser Asp Met Pro Ser Ser Ile Ile
                85                  90                  95      
Tyr Gln Asp Pro Glu Thr Gly Gly Tyr Ser Leu Glu Val Ser Gln Arg
            100                 105                 110         
Cys Gln Asp Leu Asp Thr Gly Ser Thr Ala Gln Leu Val Lys Ala Ile
        115                 120                 125             
Val Asn Pro Lys Gln Pro Lys Glu Thr Pro Lys Ser Phe Ser Phe Asp
    130                 135                 140                 
Tyr Ser Tyr Trp Ser His Thr Ser Pro Glu Asp Ile Asn Tyr Ala Ser
145                 150                 155                 160 
Gln Lys Gln Val Tyr Arg Asp Ile Gly Glu Glu Met Leu Gln His Ala
                165                 170                 175     
Phe Glu Gly Tyr Asn Val Cys Ile Phe Ala Tyr Gly Gln Thr Gly Ala
            180                 185                 190         
Gly Lys Ser Tyr Thr Met Met Gly Lys Gln Glu Lys Asp Gln Gln Gly
        195                 200                 205             
Ile Ile Pro Gln Ala Arg Ser Gly Gly Arg Ala Gly Ala Ala Leu Ala
    210                 215                 220                 
Asp Gly Ala Gly Pro Ala Glu Ala Glu Ser Ser Gly Pro Gly Thr Pro
225                 230                 235                 240 
Glu Ser Ser Pro Gln Arg Ala Gly Ser Gln Glu Gly Lys Ala Ser Trp
                245                 250                 255     
Leu Cys Glu Asp Leu Phe Ser Arg Ile Asn Asp Thr Thr Asn Asp Asn
            260                 265                 270         
Met Ser Tyr Ser Val Glu Val Gly Leu Pro Ala Cys Arg Trp Pro Leu
        275                 280                 285             
Gly Gln Gly Trp Glu Ser Gly Val Ala Gly Ser Ala Phe Leu Met Gln
    290                 295                 300                 
Arg Val Leu Met Ala Ala Pro Thr Pro Ser Leu Arg Gly Pro Asp Gly
305                 310                 315                 320 
Gly Pro Tyr Pro Leu Thr Gln Gly Pro Ser Arg Gln Pro Pro Pro Pro
                325                 330                 335     
His Ser Gly Val Leu Met Leu Ala Pro Ile Pro Ser Gly Val Leu Val
            340                 345                 350         
Ser Tyr Met Glu Ile Tyr Cys Glu Arg Val Arg Asp Leu Leu Asn Pro
        355                 360                 365             
Lys Asn Lys Gly Asn Leu Arg Val Arg Glu His Pro Leu Leu Gly Pro
    370                 375                 380                 
Tyr Val Glu Asp Leu Ser Lys Leu Ala Val Thr Ser Tyr Asn Asp Ile
385                 390                 395                 400 
Gln Asp Leu Met Asp Ser Gly Asn Lys Ala Arg Thr Val Ala Ala Thr
                405                 410                 415     
Asn Met Asn Glu Thr Ser Ser Arg Ser His Ala Val Phe Asn Ile Ile
            420                 425                 430         
Phe Thr Gln Lys Arg His Asp Ala Glu Thr Asn Ile Thr Thr Glu Lys
        435                 440                 445             
Val Ser Lys Ile Ser Leu Val Asp Leu Ala Gly Ser Glu Arg Ala Asp
    450                 455                 460                 
Ser Thr Gly Ala Lys Gly Thr Arg Leu Lys Glu Gly Ala Asn Ile Asn
465                 470                 475                 480 
Lys Ser Leu Thr Thr Leu Gly Lys Val Ile Ser Ala Leu Ala Glu Met
                485                 490                 495     
Asp Ser Gly Pro Asn Lys Gly Glu Ala Gly Ala Cys Gly Val Gly Gly
            500                 505                 510         
Ala Ala Glu Arg Ala Thr Cys Glu Ala Ala Trp Gly Asp Ala Gly Asp
        515                 520                 525             
Cys Val Arg Asn Arg Val Gly Ser Arg Glu Ser Val Arg Gly Thr Gly
    530                 535                 540                 
Arg Asn Gly Val Ser Gln Arg Gly Asn Ala
545                 550                 


<210> 2952
<211> 556
<212> PRT
<213> Homo sapiens

<400> 2952
Met Gly Leu Ala Gln Pro Arg Leu Leu Ser Gly Pro Ser Gln Glu Ser
 1               5                  10                  15      
Pro Gln Thr Leu Gly Lys Glu Ser Arg Gly Leu Arg Gln Gln Gly Thr
            20                  25                  30          
Ser Val Ala Gln Ser Gly Ala Gln Ala Pro Gly Arg Ala His Arg Cys
        35                  40                  45              
Ala His Cys Arg Arg His Phe Pro Gly Trp Val Ala Leu Trp Leu His
    50                  55                  60                  
Thr Arg Arg Cys Gln Ala Arg Leu Pro Leu Pro Cys Pro Glu Cys Gly
65                  70                  75                  80  
Arg Arg Phe Arg His Ala Pro Phe Leu Ala Leu His Arg Gln Val His
                85                  90                  95      
Ala Ala Ala Thr Pro Asp Leu Gly Phe Ala Cys His Leu Cys Gly Gln
            100                 105                 110         
Ser Phe Arg Gly Trp Val Ala Leu Val Leu His Leu Arg Ala His Ser
        115                 120                 125             
Ala Ala Lys Arg Pro Ile Ala Cys Pro Lys Cys Glu Arg Arg Phe Trp
    130                 135                 140                 
Arg Arg Lys Gln Leu Arg Ala His Leu Arg Arg Cys His Pro Pro Ala
145                 150                 155                 160 
Pro Glu Ala Arg Pro Phe Ile Cys Gly Asn Cys Gly Arg Ser Phe Ala
                165                 170                 175     
Gln Trp Asp Gln Leu Val Ala His Lys Arg Val His Val Ala Glu Ala
            180                 185                 190         
Leu Glu Glu Ala Ala Ala Lys Ala Leu Gly Pro Arg Pro Arg Gly Arg
        195                 200                 205             
Pro Ala Val Thr Ala Pro Arg Pro Gly Gly Asp Ala Val Asp Arg Pro
    210                 215                 220                 
Phe Gln Cys Ala Cys Cys Gly Lys Arg Phe Arg His Lys Pro Asn Leu
225                 230                 235                 240 
Ile Ala His Arg Arg Val His Thr Gly Glu Arg Pro His Gln Cys Pro
                245                 250                 255     
Glu Cys Gly Lys Arg Phe Thr Asn Lys Pro Tyr Leu Thr Ser His Arg
            260                 265                 270         
Arg Ile His Thr Gly Glu Lys Pro Tyr Pro Cys Lys Glu Cys Gly Arg
        275                 280                 285             
Arg Phe Arg His Lys Pro Asn Leu Leu Ser His Ser Lys Ile His Lys
    290                 295                 300                 
Arg Ser Glu Gly Ser Ala Gln Ala Ala Pro Gly Pro Gly Ser Pro Gln
305                 310                 315                 320 
Leu Pro Ala Gly Pro Gln Glu Ser Ala Ala Glu Pro Thr Pro Ala Val
                325                 330                 335     
Pro Leu Lys Pro Ala Gln Glu Pro Pro Pro Gly Ala Pro Pro Glu His
            340                 345                 350         
Pro Gln Asp Pro Ile Glu Ala Pro Pro Ser Leu Tyr Ser Cys Asp Asp
        355                 360                 365             
Cys Gly Arg Ser Phe Arg Leu Glu Arg Phe Leu Arg Ala His Gln Arg
    370                 375                 380                 
Gln His Thr Gly Glu Arg Pro Phe Thr Cys Ala Glu Cys Gly Lys Asn
385                 390                 395                 400 
Phe Gly Lys Lys Thr His Leu Val Ala His Ser Arg Val His Ser Gly
                405                 410                 415     
Glu Arg Pro Phe Ala Cys Glu Glu Cys Gly Arg Arg Phe Ser Gln Gly
            420                 425                 430         
Ser His Leu Ala Ala His Arg Arg Asp His Ala Pro Asp Arg Pro Phe
        435                 440                 445             
Val Cys Pro Asp Cys Gly Lys Ala Phe Arg His Lys Pro Tyr Leu Ala
    450                 455                 460                 
Ala His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Val Cys Pro Asp
465                 470                 475                 480 
Cys Gly Lys Ala Phe Ser Gln Lys Ser Asn Leu Val Ser His Arg Arg
                485                 490                 495     
Ile His Thr Gly Glu Arg Pro Tyr Ala Cys Pro Asp Cys Asp Arg Ser
            500                 505                 510         
Phe Ser Gln Lys Ser Asn Leu Ile Thr His Arg Lys Ser His Ile Arg
        515                 520                 525             
Asp Gly Ala Phe Cys Cys Ala Ile Cys Gly Gln Thr Phe Asp Asp Glu
    530                 535                 540                 
Glu Arg Leu Leu Ala His Gln Lys Lys His Asp Val
545                 550                 555     


<210> 2953
<211> 237
<212> PRT
<213> Homo sapiens

<400> 2953
Met Asp Ser Ser Gly Leu Lys Arg Lys Asn Asp Ser Arg Gly Ala Arg
 1               5                  10                  15      
Ser Pro Arg Pro Pro Gly Gly Cys Ala Arg Gln Arg Pro Thr Glu Ala
            20                  25                  30          
Gly Arg Asp Ala Glu Gln Pro Val Trp Ala Asp Arg Val Arg Gly Gly
        35                  40                  45              
Ala Ala Ala Ala Ala Gly Leu Gly Arg Ala Arg Arg Gly Leu Ala Glu
    50                  55                  60                  
Ser Asp Leu Leu Cys Phe Leu Thr Ala Leu Met Leu Leu Gln Met Leu
65                  70                  75                  80  
Trp Tyr Val Gly Arg Ser Ser Ala His Arg Arg Leu Phe Arg Leu Lys
                85                  90                  95      
Asp Thr His Ala Gly Ala Gly Trp Leu His Arg Leu Glu Pro Pro Leu
            100                 105                 110         
Arg Leu Gln Thr Leu Pro Ser Leu Gln Pro Gln Leu Gln Lys Pro Leu
        115                 120                 125             
Leu Ser Phe Pro Gly Leu Lys Pro Tyr Ser Gly Pro Thr Asp Pro Met
    130                 135                 140                 
Arg Glu Glu Cys Leu Phe His Ser Pro Thr Cys Pro Ser Ala Phe Arg
145                 150                 155                 160 
Asp Arg Pro Gln Ala Ser Pro His Ser Pro Arg Glu Ala Ser Pro Thr
                165                 170                 175     
Pro Phe Ser Ser Pro Leu Cys Arg Ser Asp Arg Thr Leu Pro Ala Arg
            180                 185                 190         
Thr Gly Phe Gln Cys Ser Cys Arg His Val Cys Thr Leu His Ser Thr
        195                 200                 205             
Gly Glu Leu Cys Asp Pro Cys Leu Ser Val Leu Glu Pro Pro Gln Gly
    210                 215                 220                 
Leu Ala Gln Val Gly Val Glu Lys Met Arg Gly Asp Glu
225                 230                 235         


<210> 2954
<211> 222
<212> PRT
<213> Homo sapiens

<400> 2954
Met Ala Gly Gly Lys Gly Glu Arg Asp Arg Arg His Phe Leu Arg Gln
 1               5                  10                  15      
Leu Arg Gln Arg Phe Asp Arg Leu Ser Arg Arg Arg Arg Val Ser Val
            20                  25                  30          
Pro Pro Pro Glu Ala Asp Ser Val Leu Gln Asn His Ser Ala Gln Gly
        35                  40                  45              
Leu Arg Glu Pro Lys Ile Ser Glu Arg Ala Ala Leu Ser Trp Leu Tyr
    50                  55                  60                  
Leu Thr Thr Asp Leu Glu Met Ala Phe Ala Gly Ser Lys Gly Pro Cys
65                  70                  75                  80  
Ser Pro Arg Gly Gly Pro Thr Ser His Pro His His Tyr Pro Cys Pro
                85                  90                  95      
Gly Gly Ala Pro Val Arg Asn Thr Gly Ser Glu Asp Gly Ser Gly Ser
            100                 105                 110         
Ser Ala Ala Ala Pro Lys Ala Thr Gly Gln Gly Gly His Arg Leu Pro
        115                 120                 125             
His Trp Val Lys Ala Ala Arg Arg Thr Gly Arg Ala Ile Pro Gly Ala
    130                 135                 140                 
Thr Gly Arg Ser Ala Ser Leu Gly Pro Pro Gly Gly Ser Gly Arg Gly
145                 150                 155                 160 
Leu Asn Arg Gly Val Ser Gly Gly Phe Leu Lys Gln Ala Arg Gly Arg
                165                 170                 175     
Ala Gly Glu Gly His Ser Ala Ile Leu Leu Ala Pro Glu Ser Pro Asn
            180                 185                 190         
Ala Gln Val Ser Asn Val Thr Ser Ala Thr Tyr Arg Ser Asn Leu Ser
        195                 200                 205             
Gly Phe Pro Arg Pro Cys Ser Val Val Leu Pro Gly Gly Pro
    210                 215                 220         


<210> 2955
<211> 443
<212> PRT
<213> Homo sapiens

<400> 2955
Met Gly Glu Ser Gln Glu Pro Phe Cys Lys Glu Leu His Pro Ile Glu
 1               5                  10                  15      
Pro Lys Asp Gln Lys Arg Val Lys Thr Gly Ser Val Arg Met Cys Glu
            20                  25                  30          
Gly Ile Thr Val Arg Glu Lys Ala Lys Ser His Leu Pro Thr Phe Tyr
        35                  40                  45              
Val Arg Val Ser Lys Glu Ala Leu Gln Lys Leu Pro Met Arg Lys Asn
    50                  55                  60                  
Gly Gly Ser Glu Ala Lys Cys Val Arg Lys Glu Lys Gly Gln Glu Lys
65                  70                  75                  80  
Asp Leu Leu Leu Trp Gln Gln Leu Val Lys Arg Arg Lys Pro Cys Met
                85                  90                  95      
Ser Leu Pro Cys Pro Val Ala Cys Thr His Arg Ser Ile Lys Val Asn
            100                 105                 110         
Glu Ala Arg Val Arg Asp Ser Ser Gln Arg Gln Arg Pro Arg Glu Ser
        115                 120                 125             
Pro Ala Arg Ala Ser Arg Glu Arg Ala Pro Leu Gln Ala Leu Ala Gln
    130                 135                 140                 
Gly Ala Ser Gln Ser Trp Glu Thr Ala Ala Pro Ala Ser Pro Ala Ala
145                 150                 155                 160 
Lys Gln Gly Arg Ile Ser Ser Pro Arg Val Ala Gly Gly Ser Gly Cys
                165                 170                 175     
Thr Gly Arg Ala Leu Leu Leu Ala Ala Gly Leu Gln Asn Ser Ile Arg
            180                 185                 190         
Ser Leu Asn Pro Cys Asp Pro Pro Thr Ile Leu Ser His Arg Pro Leu
        195                 200                 205             
Gln Gly Met Gln Thr His Gln Arg Leu Leu Thr Leu Pro Pro Gln Thr
    210                 215                 220                 
Cys Arg Ser Leu His Ser Pro Ala Asn Cys Ser Leu His Leu Arg Pro
225                 230                 235                 240 
Thr Pro Pro His Lys Pro Pro Pro Ser Arg Val Ser Tyr Leu Val Ala
                245                 250                 255     
Phe Pro Arg Gly Ile Pro Asp Ala Ile Gly Asp Ser Cys Gly Leu Ile
            260                 265                 270         
His Val Gln Arg Lys Leu Arg Gly Pro Asp Ser Leu Pro Ser Lys Leu
        275                 280                 285             
Pro Arg Arg Val Glu Gly Gly Asp Arg Ala Glu Ser Gly Arg Ala Arg
    290                 295                 300                 
Gly Glu Pro Pro Arg Cys Arg Leu Leu Cys Arg Gly Gly Lys Ile Arg
305                 310                 315                 320 
Ser Pro Glu Leu Glu Lys Glu Lys Gln Leu Leu Gly Pro Arg Arg Glu
                325                 330                 335     
Ala Gly Pro Ala Pro Ala Ala Pro Arg Ala Leu Cys Pro Val Leu Pro
            340                 345                 350         
Pro Arg Glu Thr Val Gln Asp Ala Gln Asp Gln Lys Arg Glu Gln Thr
        355                 360                 365             
Gln Lys Glu Leu Gln Gly Gly Gly Arg Ala Thr Ala Ala Arg Ser Pro
    370                 375                 380                 
Arg Pro Leu Ile Ser His Gln Asp Leu Met Val Val Glu Thr Met Gln
385                 390                 395                 400 
Lys Ala Lys Gly Arg Glu Pro Ala Asp Ala Val His Thr Ala Gly Val
                405                 410                 415     
Leu Thr Val Ile Phe Ala Ile Gln Thr Phe Arg Ala Ile Arg Thr Gly
            420                 425                 430         
Asp Ser Lys Arg Asn Ala Cys Trp Gly Ala Gln
        435                 440             


<210> 2956
<211> 409
<212> PRT
<213> Homo sapiens

<400> 2956
Met His Asp Phe Pro Leu Pro Asn Asn Leu Ile Ile His Glu Leu Ala
 1               5                  10                  15      
Cys Ala Phe Ser Val Ser Leu Trp Phe Pro Phe Thr Thr Leu Ala Ser
            20                  25                  30          
Thr Trp Leu Gln Val Ala Thr Asn Ser Thr Pro Lys Arg His Pro Phe
        35                  40                  45              
Ser Phe Cys Pro Cys Gly Lys Thr Tyr Trp Tyr Phe Leu Ile Gln Ile
    50                  55                  60                  
Pro Lys Arg Arg Asn Leu Ile Glu Tyr Leu Leu Leu Cys Val Lys Pro
65                  70                  75                  80  
Tyr Val Ile Val Gln Ala Thr Glu Trp Pro Leu Gly Ser Val Ser Ile
                85                  90                  95      
Gln Gly Gln Ser Val Met Ala Thr Gly Ile Leu Asp Gly Val Lys Arg
            100                 105                 110         
Gly Tyr Leu Gly Leu Pro Trp Val Phe Tyr Pro Gly Cys Gly Gln Ala
        115                 120                 125             
Gly Gln Lys Ser Ser His Arg Pro Ser Ile Thr Ser Ile Leu Asp Lys
    130                 135                 140                 
Lys Pro Lys Glu Pro Asp Phe Pro Pro Gly Ser Lys Ser Pro His Ile
145                 150                 155                 160 
Tyr Cys Phe Gly Ala Lys Ala Pro Pro Pro Ala Thr Pro Ala His Asn
                165                 170                 175     
Pro Gly Leu Ser Ser Thr Ala Val Leu Asn Ala Lys Cys Pro Ala Arg
            180                 185                 190         
Val Pro Glu Ile Gly Met Gln Glu Arg Asp Tyr Gly Pro Glu Ala Gln
        195                 200                 205             
Leu His Leu Glu Ala Leu Gly Val Pro Lys Pro Trp Ala Thr Ser Pro
    210                 215                 220                 
Ser Ala Leu Pro Gly Glu Asp Ser Tyr Arg Pro Arg Leu Pro Glu Leu
225                 230                 235                 240 
Arg Ser Arg Ala Glu Pro Pro Ala Arg Val Leu Arg Arg Ala Leu Arg
                245                 250                 255     
Lys Pro Gly Arg Ala Ala Val Arg Glu Leu Gly Arg Val Gly Arg Ala
            260                 265                 270         
Gly Thr Arg Ala Ser Gln Ser Tyr Met Asn Ser Pro Cys Leu Gly Lys
        275                 280                 285             
Leu Asp Asp Leu Cys Ser Leu Thr Lys Glu Glu Thr Leu Ser Ile Phe
    290                 295                 300                 
His Arg Asp Leu Gln Thr Pro Lys Pro Thr Gln Ile Gln Thr His Leu
305                 310                 315                 320 
Ser Thr His Arg His Ser Gln Ala Leu Leu Glu Gly Ala Met Glu Lys
                325                 330                 335     
Glu Met Arg Ala Ala Gln Glu Gln Val Val Arg Gln Ser Trp Leu Leu
            340                 345                 350         
Gly Leu Ser Leu Pro Ile Pro Ala Leu His Tyr Asp Cys His Pro Phe
        355                 360                 365             
Arg Arg Thr Ser Leu Lys Ala Ser Glu Ser Thr Pro Asp Thr Ile Arg
    370                 375                 380                 
Val Gln Ser Val Gln Leu Asn Lys Asp Leu Ser Ser Val Phe Ala Val
385                 390                 395                 400 
Glu Asn Ile Val Val Ala Cys Tyr Glu
                405                 


<210> 2957
<211> 729
<212> PRT
<213> Homo sapiens

<400> 2957
Met Thr Ile Asp Leu Ser Pro Tyr Thr Val Ile Leu Thr Val Gly Cys
 1               5                  10                  15      
Phe Glu Ser Gly Ser Asp Ile Ser Pro Cys Phe Ser Leu Glu Lys Glu
            20                  25                  30          
Ala Pro Ala Phe Pro Pro Glu Ser Pro Phe Thr Gln Arg Leu Leu Val
        35                  40                  45              
Thr Ala Val Pro Thr Gly Val Cys Arg Ile Ser Val Pro Ala Val Lys
    50                  55                  60                  
Val Phe Ser Pro His Arg Ala Arg Asn Tyr Leu Ala Gln Thr Glu Lys
65                  70                  75                  80  
Ala Arg Arg Asn Thr Ala Gly Lys Pro Met Ala Phe Pro Gly Gly Tyr
                85                  90                  95      
Pro Gly Asp Cys Thr His Arg Ser Ala Cys Ser Glu Lys Pro Leu Pro
            100                 105                 110         
Ser Arg Pro Arg Ser Arg Ala Glu Thr Arg Gly Ser Lys Glu Asn Arg
        115                 120                 125             
Leu Glu Arg Thr Gly Ser Pro Ala Ser Val Gln Asp Thr Ala Ser Gly
    130                 135                 140                 
Ser Arg Ala Phe Cys Ser Leu Leu Ser Glu Pro Arg Asp Val Pro Arg
145                 150                 155                 160 
Ala Pro Arg Pro Leu Phe Val Ser Leu Phe Gly Val Arg Gly Pro Arg
                165                 170                 175     
Asn Arg Val Leu Ala Val Ala Arg Thr Thr Gly Lys Leu Pro Ser His
            180                 185                 190         
Pro Val Gly Ile Ser Glu Pro Ala Gly Ala Leu Gly Met Arg Phe Leu
        195                 200                 205             
Met Gly Leu Gly Ser Glu Leu Arg Cys His Ser Arg Arg Ser Gly Pro
    210                 215                 220                 
Ser Leu Ser Phe Ser Tyr Phe Gly Ala Glu Ser Gly Tyr Lys Gly Leu
225                 230                 235                 240 
Lys Asn Thr Ala Val Phe Glu Gly Leu Ser Leu Glu Asp Glu Pro Gly
                245                 250                 255     
Leu Arg Gly Val Asp Ala Phe Leu Ala Ser Trp Ser Gly Leu Ala Gly
            260                 265                 270         
Pro Thr Ser Gly Pro Glu Pro Ala Pro Thr Ala Arg Glu Leu Leu Arg
        275                 280                 285             
Gly Glu Thr Ala Ser Gly Glu Ala Ala Ala Pro Ala Leu Pro His Leu
    290                 295                 300                 
His Arg Ser Arg Pro Ile Arg Asp Val Thr Asp Ser Ala Phe Leu Val
305                 310                 315                 320 
Pro Leu Gln Gly Ser Ser Gly Arg Met Thr Glu Gln Gly Leu Gly Lys
                325                 330                 335     
Pro Glu Arg Leu Glu Arg Ser Pro Trp Lys Arg Pro Gly Leu Arg Pro
            340                 345                 350         
Gly Phe Glu Gln Pro Gly Gly Ser Arg Glu Ala Glu Arg Leu Val Gly
        355                 360                 365             
Ser Arg Asp Gly Ser Ser Arg Ser Leu His Ser Leu His Pro Val Arg
    370                 375                 380                 
Glu Pro Val Pro Ser Leu Leu Ser Arg Ile Arg Gly Ala Ala Glu Leu
385                 390                 395                 400 
Pro Leu Pro Ser Ser Asp Pro Ala Phe Gly Thr Gly Ala Pro Pro Gly
                405                 410                 415     
Gln Gly Ser Cys Pro Leu Lys Ser Leu Glu Asn Gly Asn His Glu Arg
            420                 425                 430         
Phe Phe His Gly Gly Ser Ser Phe Tyr Glu Thr Phe Ile Gln Ile Asp
        435                 440                 445             
Phe Ser Ala Pro Arg Gly Glu Gly Asn Gly Gln Gly Phe Gln Cys Thr
    450                 455                 460                 
Phe Cys Ala Val Glu Pro Arg Gly Leu Ser Trp Thr Val Val Gly Ser
465                 470                 475                 480 
Trp Gly Trp Arg Ala Gly Ala Gly Glu Gly Lys Ser Lys Ser Gly Glu
                485                 490                 495     
Arg Ser Arg Arg Ala Val Asp Gln Thr Ser Arg Pro Glu Arg Leu Val
            500                 505                 510         
Arg Arg Gln Arg Arg Asp Leu Pro Glu Arg Ala Arg Thr Met Ala Leu
        515                 520                 525             
Tyr Asn Pro Ile Pro Val Lys Gln Asn Cys Phe Thr Val Asn Arg Ser
    530                 535                 540                 
Leu Phe Val Phe Ser Glu Asp Asn Val Val Arg Lys Tyr Ala Lys Arg
545                 550                 555                 560 
Ile Thr Glu Trp Pro Pro Phe Glu Tyr Met Ile Leu Ala Thr Ile Ile
                565                 570                 575     
Ala Asn Cys Ile Val Leu Ala Leu Glu Gln His Leu Pro Asp Gly Asp
            580                 585                 590         
Lys Thr Pro Met Ser Glu Arg Leu Asp Asp Thr Glu Pro Tyr Phe Ile
        595                 600                 605             
Gly Ile Phe Cys Phe Glu Ala Gly Ile Lys Ile Ile Ala Leu Gly Phe
    610                 615                 620                 
Val Phe His Lys Gly Ser Tyr Leu Arg Asn Gly Trp Asn Val Met Asp
625                 630                 635                 640 
Phe Val Val Val Leu Thr Gly Arg Lys Ala Gly Leu Gly Cys Cys Gly
                645                 650                 655     
Ser Gly Val Glu Ser Gly Gly Trp Gly Val Ser Ala Trp Gly Val Ala
            660                 665                 670         
Pro Thr Glu Pro Val Ser Ala Ser Val Ser Glu Ala Leu Cys Trp Ala
        675                 680                 685             
Arg Asp His Cys Leu Leu Phe Ser Glu Pro Tyr Gly Ser Glu Ala Gln
    690                 695                 700                 
Ser Pro Asp Gly Arg Gly Gly Ser Arg Pro His Ser Arg Arg Glu Leu
705                 710                 715                 720 
Ser Phe Gln Ser Pro Ile Leu Thr Gln
                725                 


<210> 2958
<211> 504
<212> PRT
<213> Homo sapiens

<400> 2958
Met Lys Gly Thr Ile Ala Asn Thr Arg Arg Ile Thr Trp Lys Asp Glu
 1               5                  10                  15      
Ser Pro Arg Lys Pro Ala Gln Gly Leu Ile Arg Gly His Pro Phe Thr
            20                  25                  30          
Gln His Gln Ser Leu His Gln Gln Leu Lys Glu Arg Pro Pro Glu Ser
        35                  40                  45              
Arg Ser Leu Glu Ser Trp Leu Gln Pro Arg Lys Ala Leu Ser Thr Phe
    50                  55                  60                  
Leu Ser Thr Tyr Thr Leu Pro Gln Leu Asn Thr Pro Leu Asp Pro Lys
65                  70                  75                  80  
Ser Ser Leu Thr Leu Asn Ser Phe Ser Ile Gly Gln Gly Arg Thr Glu
                85                  90                  95      
Cys Tyr Ser Thr Pro Leu Leu Leu Gln Lys His Gln Val Thr Gly Pro
            100                 105                 110         
Gly Gly Gly Asn Ala Ala Lys Arg Lys Glu Gln Gly Tyr Ser Leu His
        115                 120                 125             
Arg Asp Leu Ala His Phe Thr Pro Gly Cys Ser Arg Gly Pro Ala Leu
    130                 135                 140                 
Thr Asp Lys Ala Gly Gly Thr Cys Arg Ile Ser Pro Ile Pro Ser Leu
145                 150                 155                 160 
His Cys Gln Leu Gly Gly Pro Met Arg Phe Pro Met Pro Ser Val Arg
                165                 170                 175     
Ala Glu Arg Pro Gly His Gly Leu Cys Pro Glu Val Gln Ala Ala Ala
            180                 185                 190         
Gly Thr Pro Leu Ile Glu Ser Cys Thr Arg Pro Thr Pro Ala Ala Pro
        195                 200                 205             
Thr Trp Leu Pro Pro Arg Leu Gly Leu Gly Arg Arg Pro Ser Leu Gly
    210                 215                 220                 
Gly Arg Gly Cys Met Ser Glu Arg Gln Gly Glu Gly Lys Glu Thr Gln
225                 230                 235                 240 
Ser Gly Leu Gln Gln Arg Ser His Gly Cys Tyr Leu Gly Tyr Phe Ile
                245                 250                 255     
Pro Pro Pro Ser Arg Thr Val Pro Tyr Pro Glu Glu Thr Gln Leu Ala
            260                 265                 270         
Gly Pro Ala Val Phe Arg Val Thr His Arg Ser Glu Arg Val Gly Lys
        275                 280                 285             
Val Asp Ser Val Gly Pro Gly Thr Thr Ala Ala Thr Ala Thr Ala Asp
    290                 295                 300                 
Ser Ile Ile Ala Ser Leu Leu Met Pro Pro Leu Leu Leu His Gln Pro
305                 310                 315                 320 
Leu Pro Val Cys Cys Pro Thr Cys Lys Pro Ile Asp Met Leu His Phe
                325                 330                 335     
Pro Pro Arg Thr Gln Ile Val Pro Tyr Ala Ala Trp Val Ala Leu Pro
            340                 345                 350         
Ser Pro Phe Leu Leu Leu Ser Lys Val Glu Gly Lys Ala Asp Lys Gly
        355                 360                 365             
Asp Phe Tyr Asn His Thr Lys Lys Arg Gln Trp Gly Glu Asn Ile Gln
    370                 375                 380                 
Cys Glu Thr Ser Asn Gly Phe Glu Met Lys Lys Ala Ser Leu Cys Ser
385                 390                 395                 400 
Ile Thr Ile Ser Gln His Trp Asn Thr His Gly Ala Ser Gly Cys Ser
                405                 410                 415     
Ser Thr His Tyr Ile Tyr Asp Ile Ala Leu Gln Arg Glu Val Met Trp
            420                 425                 430         
Gln Leu Cys Ala Ile Lys Ile Thr Glu Ala Ile Gln Tyr Val Val Glu
        435                 440                 445             
Phe Ala Lys Arg Ile Asp Gly Phe Met Glu Leu Cys Gln Asn Asn Gln
    450                 455                 460                 
Ile Val Leu Leu Lys Ala Gly Cys Ser Asp Ala Gln Val Cys Glu His
465                 470                 475                 480 
Cys Thr Cys Arg Leu Glu Leu Arg Glu Gln Ser Glu Gly Glu Thr Gln
                485                 490                 495     
Thr Gly Asp Val Gly Pro Glu Leu
            500                 


<210> 2959
<211> 230
<212> PRT
<213> Homo sapiens

<400> 2959
Met His Ser Ser Ser Pro Ser Pro Thr Asn Asp Arg Gly Leu Arg Arg
 1               5                  10                  15      
Thr Ile Arg Leu Ala Pro Leu Ser Phe Gly Leu Arg Phe Leu Thr Ser
            20                  25                  30          
Cys Ser Leu Leu Leu Pro Arg Ala Ala Gln Ile Leu Ala Ala Glu Ala
        35                  40                  45              
Gly Leu Pro Ser Ser Arg Ser Phe Met Gly Phe Ala Ala Pro Phe Thr
    50                  55                  60                  
Asn Lys Arg Lys Ala Tyr Ser Glu Arg Arg Ile Met Gly Tyr Ser Met
65                  70                  75                  80  
Gln Glu Met Tyr Glu Val Val Ser Asn Val Gln Glu Tyr Arg Glu Phe
                85                  90                  95      
Val Pro Trp Cys Lys Lys Ser Leu Val Val Ser Ser Arg Lys Gly His
            100                 105                 110         
Leu Lys Ala Gln Leu Glu Val Gly Phe Pro Pro Val Met Glu Arg Tyr
        115                 120                 125             
Thr Ser Ala Val Ser Met Val Lys Pro His Met Val Lys Ala Val Cys
    130                 135                 140                 
Thr Asp Gly Lys Leu Phe Asn His Leu Glu Thr Ile Trp Arg Phe Ser
145                 150                 155                 160 
Pro Gly Ile Pro Ala Tyr Pro Arg Thr Cys Thr Val Asp Phe Ser Ile
                165                 170                 175     
Ser Phe Glu Phe Arg Ser Leu Leu His Ser Gln Leu Ala Thr Met Phe
            180                 185                 190         
Phe Asp Glu Val Val Lys Gln Asn Val Ala Ala Phe Glu Arg Arg Ala
        195                 200                 205             
Ala Thr Lys Phe Gly Pro Glu Thr Ala Ile Pro Arg Glu Leu Met Phe
    210                 215                 220                 
His Glu Val His Gln Thr
225                 230 


<210> 2960
<211> 111
<212> PRT
<213> Homo sapiens

<400> 2960
Met Gly Arg Gly Ser Gly Ile Leu Ser Val Ala Phe Trp Gly Thr Asp
 1               5                  10                  15      
Ser Thr Arg Pro Ser Ser Cys Val Val Ser Ala Asp Gln Ala Leu Cys
            20                  25                  30          
Gly Leu Glu Glu Cys Arg Pro Leu Leu Leu Arg Pro Gly Pro Arg Ala
        35                  40                  45              
Ser Val Met Gly Ala Pro Gln Glu Gly Ser Asp Ala Gly Arg Gly Arg
    50                  55                  60                  
Phe Leu Gly Ser Glu Val Arg His Ser Gly Pro Gly Ala Ala Phe Thr
65                  70                  75                  80  
Pro Gly Val Ser Phe His Phe Gln Leu Glu Ser Ala Ala Thr Pro Ile
                85                  90                  95      
Ser Cys Phe Pro Phe Pro Arg Ser Gly Arg Ala Pro Leu Pro Thr
            100                 105                 110     


<210> 2961
<211> 93
<212> PRT
<213> Homo sapiens

<400> 2961
Met Ala Pro Arg Pro Trp Leu Trp Ala Ser Ala Arg Trp Trp Gly Gln
 1               5                  10                  15      
Ala Pro Cys Thr Ala Ala Thr Cys Cys Ser Leu Pro Gly Tyr Val Arg
            20                  25                  30          
Leu Pro Thr Pro Pro Ser Ala Val Ala Pro Arg Ala Pro Pro Ala Pro
        35                  40                  45              
Cys His Pro Leu Ser Cys Ala Phe Ala Gly Leu Gly Pro Arg Gln Glu
    50                  55                  60                  
Gly Gly Ser Ser Gly Ser Gln Ser Thr Gln Ala Ala Arg Lys Gln Pro
65                  70                  75                  80  
Met Thr Ser Ser Asp Gly Ile Arg Gly Val Arg Val Asp
                85                  90              


<210> 2962
<211> 47
<212> PRT
<213> Homo sapiens

<400> 2962
Met Trp Glu Ser Gly Pro Gly Thr Cys Ser Pro Thr Arg Arg Gln Ser
 1               5                  10                  15      
Pro Ser Cys Ala Ser Ser Arg Ala Ala Ala Arg Ala Thr Ala Thr Thr
            20                  25                  30          
Ala Leu Cys Ala Gly Thr Thr Arg Ser Ile Thr Ala Cys Ala Ser
        35                  40                  45          


<210> 2963
<211> 2237
<212> PRT
<213> Homo sapiens

<400> 2963
Met Leu Leu Leu Arg Ala Ala Val Gln Pro Ala Leu Ala Trp Glu Pro
 1               5                  10                  15      
Glu Asp Thr Arg Gly Gly Val Gly Arg Ala Gly Arg Pro Arg Ser Ser
            20                  25                  30          
Ser Ser Gln Ser Cys Cys Pro Thr Cys Thr Pro Val Gly Thr Arg Arg
        35                  40                  45              
His Ser Trp Arg Arg Arg Gln Ser Arg Gln Thr Lys Glu Phe Ile Phe
    50                  55                  60                  
Ser Glu Leu Leu Ser Asn Leu His Ser Arg Gly Asn Glu Lys Thr Leu
65                  70                  75                  80  
Met Glu Glu Ser Ala Glu Gln Ala Gln Arg Arg Asp Glu Thr Arg Val
                85                  90                  95      
Gly Arg Arg Arg His Ser Trp Arg Ser Arg Gln Ser Arg Gln Thr Lys
            100                 105                 110         
Glu Phe Ile Phe Ser Glu Leu Leu Ser Asn Leu Tyr Ser Arg Arg Asn
        115                 120                 125             
Leu Gln Thr Leu Val Glu Glu Ser Ala Glu Gln Ala Gln Arg Cys Asp
    130                 135                 140                 
Glu Met Leu Leu Leu Arg Ala Ala Val Gln Pro Ala Leu Ala Trp Glu
145                 150                 155                 160 
Arg Glu Asp Thr Arg Gly Gly Val Gly Arg Ala Gly Arg Pro Arg Ser
                165                 170                 175     
Ser Ser Ser Gln Ser Cys Cys Pro Thr Cys Thr Arg Val Gly Thr Arg
            180                 185                 190         
Arg His Ser Trp Arg Arg Arg Gln Ser Arg Gln Thr Lys Glu Phe Ile
        195                 200                 205             
Phe Ser Glu Leu Leu Ser Asn Leu His Ser Arg Gly Asn Glu Lys Thr
    210                 215                 220                 
Leu Met Glu Glu Ser Ala Glu Gln Ala Gln Arg Arg Asp Glu Thr Arg
225                 230                 235                 240 
Val Gly Arg Arg Arg His Ser Trp Arg Ser Arg Gln Ser Arg Gln Thr
                245                 250                 255     
Lys Glu Phe Ile Phe Ser Glu Leu Leu Ser Asn Leu Tyr Ser Arg Gly
            260                 265                 270         
Lys Glu Lys Thr Leu Val Glu Ala Ser Ala Glu Gln Ala Asp Gln Gly
        275                 280                 285             
Val His Leu Leu Arg Ala Ala Val Gln Pro Ala Leu Ala Gln Thr Lys
    290                 295                 300                 
Glu Phe Ile Phe Ser Glu Leu Leu Ser Asn Leu His Ser Arg Gly Asn
305                 310                 315                 320 
Glu Lys Thr Leu Val Glu Ala Ser Ala Glu Gln Ala Asp Gln Gly Val
                325                 330                 335     
His Leu Leu Arg Ala Ala Val Gln Pro Ala Leu Ala Trp Glu Arg Glu
            340                 345                 350         
Asp Thr Arg Gly Gly Val Ser Arg Glu Gly Arg Pro Arg Ser Ser Ser
        355                 360                 365             
Ser Gln Ser Cys Cys Pro Thr Phe Thr Arg Ala Gly Thr Arg Arg His
    370                 375                 380                 
Ser Trp Arg Arg Arg Gln Ser Arg Gln Thr Lys Glu Phe Ile Phe Ser
385                 390                 395                 400 
Glu Leu Leu Ser Asn Leu Tyr Ser Arg Gly Asn Glu Gln Thr Leu Val
                405                 410                 415     
Glu Ala Ser Ala Glu Gln Ala Asp Gln Gly Val His Leu Leu Arg Ala
            420                 425                 430         
Ala Val Gln Pro Ala Leu Ala Arg His Ser Trp Arg Arg Arg Gln Ser
        435                 440                 445             
Arg Gln Thr Lys Glu Phe Ile Phe Ser Glu Leu Leu Ser Asn Leu Tyr
    450                 455                 460                 
Ser Arg Gly Asn Glu Gln Thr Leu Val Glu Ala Ser Ala Glu Gln Ala
465                 470                 475                 480 
Asp Gln Gly Val His Leu Leu Arg Ala Ala Val Gln Pro Ala Leu Ala
                485                 490                 495     
Arg His Ser Trp Arg Arg Arg Gln Ser Arg Gln Thr Lys Glu Phe Ile
            500                 505                 510         
Phe Ser Glu Leu Leu Ser Lys Leu His Ser Arg Gly Asn Glu Arg Thr
        515                 520                 525             
Leu Met Glu Glu Ser Ala Glu Gln Ala Gln Arg Cys Asp Glu Thr Arg
    530                 535                 540                 
Val Gly Arg Arg Arg His Ser Trp Arg Ser Arg Gln Ser Arg Pro Thr
545                 550                 555                 560 
Lys Glu Phe Ile Phe Ser Glu Leu Leu Ser Asn Leu Tyr Ser Ala Ser
                565                 570                 575     
Glu Pro Ala Asp Thr Arg Gly Gly Ser Arg Gln Thr Lys Glu Phe Ile
            580                 585                 590         
Phe Ser Glu Leu Leu Ser Asn Leu Tyr Ser Arg Gly Asn Glu Lys Thr
        595                 600                 605             
Leu Val Glu Ala Ser Ala Glu Gln Ala Asp Gln Gly Val His Leu Leu
    610                 615                 620                 
Arg Ala Ala Val Gln Pro Val Leu Ala Trp Glu Arg Glu Asp Thr Arg
625                 630                 635                 640 
Gly Gly Ser Arg Gln Thr Lys Glu Phe Ile Phe Ser Glu Leu Leu Ser
                645                 650                 655     
Asn Leu His Ser Arg Gly Asn Glu Lys Thr Leu Met Glu Glu Ser Ala
            660                 665                 670         
Glu Gln Ala Gln Arg Arg Asp Glu Thr Arg Val Gly Arg Arg Arg His
        675                 680                 685             
Ser Trp Arg Ser Arg Gln Ser Lys His Thr Lys Glu Phe Ile Phe Ser
    690                 695                 700                 
Glu Leu Leu Ser Asn Leu Tyr Ser Arg Arg Asn Leu Gln Thr Leu Val
705                 710                 715                 720 
Glu Glu Ser Ala Glu Gln Ala Gln Arg Cys Cys Pro Thr Cys Thr Arg
                725                 730                 735     
Val Gly Thr Arg Arg His Ser Trp Arg Arg Arg Gln Ser Arg Gln Thr
            740                 745                 750         
Lys Glu Phe Ile Phe Ser Glu Leu Leu Ser Asn Leu Tyr Ser Arg Gly
        755                 760                 765             
Asn Glu Lys Thr Leu Val Glu Ala Ser Ala Glu Gln Ala Asp Gln Gly
    770                 775                 780                 
Val His Leu Leu Arg Ala Ala Val Gln Pro Ala Leu Ala Trp Glu Arg
785                 790                 795                 800 
Glu Asp Thr Arg Gly Gly Ser Arg Gln Thr Lys Glu Phe Ile Phe Ser
                805                 810                 815     
Glu Leu Leu Ser Lys Leu His Ser Arg Gly Asn Glu Lys Thr Leu Met
            820                 825                 830         
Glu Glu Ser Ala Glu Gln Ala Gln Arg Cys Asp Glu Thr Arg Val Gly
        835                 840                 845             
Arg Arg Arg His Ser Trp Arg Ser Arg Gln Ser Arg Pro Thr Lys Glu
    850                 855                 860                 
Phe Ile Phe Ser Glu Leu Leu Ser Asn Leu Tyr Ser Arg Arg Asn Leu
865                 870                 875                 880 
Gln Thr Leu Val Glu Glu Ser Ala Glu Gln Ala Gln Arg Cys Asp Glu
                885                 890                 895     
Met Leu Leu Leu Arg Ala Ala Val Gln Pro Ala Leu Thr Trp Glu Arg
            900                 905                 910         
Glu Asp Thr Arg Gly Gly Ser Arg Gln Thr Lys Glu Phe Ile Phe Ser
        915                 920                 925             
Glu Leu Leu Ser Asn Leu Tyr Ser Arg Gly Asn Glu Lys Thr Leu Val
    930                 935                 940                 
Glu Ala Ser Ala Glu Gln Ala Asp Gln Gly Val His Leu Leu Arg Ala
945                 950                 955                 960 
Ala Val Gln Pro Ala Leu Ala Trp Glu Arg Glu Asp Thr Arg Gly Gly
                965                 970                 975     
Ser Arg Gln Thr Lys Glu Phe Ile Phe Ser Glu Leu Leu Ser Lys Leu
            980                 985                 990         
His Ser Arg Gly Asn Glu Lys Thr Val Met Glu Glu Ser Ala Glu Gln
        995                 1000                1005            
Ala Gln Arg Cys Asp Glu Thr Arg Val Gly Arg Arg Arg His Ser Trp
    1010                1015                1020                
Arg Ser Arg Gln Ser Arg Pro Thr Lys Glu Phe Ile Phe Ser Glu Leu
1025                1030                1035                1040
Leu Ser Asn Leu Tyr Ser Arg Arg Asn Leu Gln Thr Leu Val Glu Glu
                1045                1050                1055    
Ser Ala Glu Gln Ala Gln Arg Cys Asp Glu Met Leu Leu Leu Arg Ala
            1060                1065                1070        
Ala Val Gln Pro Ala Leu Ala Trp Glu Gln Glu Asp Thr Arg Gly Gly
        1075                1080                1085            
Val Gly Arg Ala Gly Arg Pro Arg Ser Ser Ser Ser Gln Ser Cys Cys
    1090                1095                1100                
Pro Thr Cys Thr Arg Val Gly Thr Arg Arg His Ser Trp Arg His Arg
1105                1110                1115                1120
Gln Ser Arg Gln Thr Lys Glu Phe Ile Phe Ser Glu Leu Leu Ser Asn
                1125                1130                1135    
Leu His Ser Arg Gly Asn Glu Lys Thr Leu Met Glu Glu Ser Ala Glu
            1140                1145                1150        
Gln Ala Gln Arg Arg Asp Glu Thr Arg Val Gly Arg Arg Arg His Ser
        1155                1160                1165            
Trp Arg Ser Arg Gln Ser Arg Gln Ile Lys Glu Phe Ile Phe Ser Glu
    1170                1175                1180                
Leu Leu Ser Asn Leu Tyr Ser Arg Arg Asn Leu Gln Thr Leu Val Glu
1185                1190                1195                1200
Glu Ser Ala Glu Gln Ala Gln Arg Cys Asp Glu Met Leu Leu Leu Arg
                1205                1210                1215    
Ala Ala Val Gln Pro Ala Leu Ala Trp Glu Arg Glu Asp Thr Arg Gly
            1220                1225                1230        
Gly Ser Arg Gln Thr Lys Glu Phe Ile Phe Ser Glu Leu Leu Ser Asn
        1235                1240                1245            
Leu Tyr Ser Arg Gly Asn Glu Lys Thr His Val Glu Ala Ser Ala Glu
    1250                1255                1260                
Gln Ala Asp Gln Gly Leu His Leu Leu Arg Ala Ala Val Gln Pro Ala
1265                1270                1275                1280
Leu Ala Trp Glu Arg Glu Asp Thr Arg Gly Gly Ser Arg Gln Thr Lys
                1285                1290                1295    
Glu Phe Ile Phe Ser Glu Leu Leu Ser Lys Leu His Leu Arg Gly Asn
            1300                1305                1310        
Glu Lys Thr Leu Met Glu Glu Ser Ala Glu Gln Ala Gln Arg Cys Asp
        1315                1320                1325            
Glu Thr Arg Val Gly Arg Arg Arg His Ser Trp Arg Ser Arg Gln Ser
    1330                1335                1340                
Arg Gln Thr Lys Glu Phe Ile Phe Ser Asp Leu Leu Ser Asn Leu Tyr
1345                1350                1355                1360
Ser Arg Arg Asn Leu Gln Thr Leu Val Glu Glu Ser Ala Glu Gln Ser
                1365                1370                1375    
Gln Arg Cys Asp Glu Met Leu Leu Leu Arg Ala Ala Val Gln Pro Ala
            1380                1385                1390        
Leu Ala Trp Glu Gln Glu Asp Thr Arg Gly Gly Val Gly Arg Ala Gly
        1395                1400                1405            
Arg Pro Arg Ser Ser Ser Ser Gln Ser Cys Cys Pro Thr Cys Thr Arg
    1410                1415                1420                
Val Gly Thr Arg Arg His Ser Trp Arg Arg Arg Gln Ser Arg Gln Thr
1425                1430                1435                1440
Lys Glu Phe Ile Phe Ser Glu Leu Leu Ser Asn Leu His Ser Arg Gly
                1445                1450                1455    
Asn Glu Lys Thr Leu Ile Arg Arg His Ser Trp Arg Ser Arg Gln Ser
            1460                1465                1470        
Arg Gln Thr Lys Glu Phe Ile Phe Ser Glu Leu Leu Ser Asn Leu Tyr
        1475                1480                1485            
Ser Arg Arg Asn Leu Gln Thr Leu Val Glu Glu Ser Ala Glu Gln Ala
    1490                1495                1500                
Gln Arg Cys Asp Glu Met Leu Leu Leu Arg Ala Ala Val Gln Pro Ala
1505                1510                1515                1520
Leu Ala Trp Glu Arg Glu Asp Thr Arg Gly Gly Val Gly Arg Ala Gly
                1525                1530                1535    
Arg Pro Arg Ser Ser Phe Ser Gln Ser Cys Cys Pro Thr Cys Thr Pro
            1540                1545                1550        
Val Gly Thr Arg Arg His Ser Trp Arg Cys Arg Gln Ser Arg Gln Thr
        1555                1560                1565            
Lys Glu Phe Ile Phe Ser Glu Leu Leu Ser Lys Leu His Ser Arg Gly
    1570                1575                1580                
Asn Glu Lys Thr Leu Ile Tyr Val Thr His Leu Met Lys Arg Ile Gln
1585                1590                1595                1600
Arg Gly Pro Val Arg Gly Ile Ser Ile Lys Leu Gln Glu Glu Glu Arg
                1605                1610                1615    
Glu Arg Arg Asp Asn Tyr Val Pro Glu Val Ser Ala Leu Asp Gln Glu
            1620                1625                1630        
Ile Ile Glu Val Asp Pro Asp Thr Lys Glu Met Leu Lys Leu Leu Val
        1635                1640                1645            
Ala Gln Glu Ala Val Pro Pro Ala Asp Ile Val Phe Ser Val Lys Ser
    1650                1655                1660                
Pro Pro Ser Ala Gly Tyr Leu Val Met Val Leu Arg Gly Ile Leu Ala
1665                1670                1675                1680
Asp Glu Pro Pro Ser Leu Asp Pro Val Gln Ser Phe Ser Gln Glu Ala
                1685                1690                1695    
Val Asp Thr Gly Arg Ile Leu Tyr Leu His Ser Arg Pro Glu Ala Arg
            1700                1705                1710        
Ser His Ala Phe Ser Leu Asp Val Ala Ser Ala Trp Val Leu Pro Leu
        1715                1720                1725            
Glu Asp Val Thr Trp Ser Trp Arg Ser Tyr Phe Pro Thr Leu Pro Gly
    1730                1735                1740                
Leu Gly Leu Gln Val Leu Glu Pro Pro Arg His Gly Ala Leu Gln Lys
1745                1750                1755                1760
Glu Asp Gly Pro Gln Ala Arg Thr Leu Ser Thr Phe Cys Trp Arg Glu
                1765                1770                1775    
Lys Leu Gly Tyr Asp Lys Leu Ala Glu Ala Leu Arg Val Gly Ala Val
            1780                1785                1790        
Asn Glu Ala Thr Cys Thr Trp Ser Gly Gln Leu Pro Pro Arg Asn Tyr
        1795                1800                1805            
Lys Asn Pro Ile Tyr Ser Cys Lys Val Phe Leu Gly Gly Val Pro Trp
    1810                1815                1820                
Asp Ile Thr Glu Ala Gly Leu Val Asn Thr Phe Arg Val Phe Gly Ser
1825                1830                1835                1840
Leu Ser Val Glu Trp Pro Gly Lys Asp Gly Lys His Pro Arg Cys Pro
                1845                1850                1855    
Pro Lys Gly Pro Thr Tyr Gln Ile Trp Val Thr Gly Pro Pro Ser Ala
            1860                1865                1870        
Ala Arg Asn Arg Arg Gln Ala Arg Gly Leu Pro Gly Asp Gln Gly Pro
        1875                1880                1885            
Ser Val Ala Ser Pro Ser Arg Thr Val Pro Arg Gly Glu Pro Leu Thr
    1890                1895                1900                
Gly Asp Gln Gln Ala Ala Leu Leu Pro Pro Gly Gly Cys Arg Arg Arg
1905                1910                1915                1920
Glu Thr Arg Pro Lys Arg Thr Ser Gly Val Gln Trp Arg Lys Val Arg
                1925                1930                1935    
His Gly Lys Ala Trp Pro Glu His Cys Asp Phe Ser Glu Ala Pro Ser
            1940                1945                1950        
Thr Pro Leu Ser Phe Pro Gly Leu Lys Val Glu Phe Arg Gln Arg Ile
        1955                1960                1965            
Gln Gly Gln Ile Ser Ile Lys Val Ser Gln Pro Pro Glu His Gly Ala
    1970                1975                1980                
Phe Lys Phe Pro Val Ser Gln Arg Leu Arg Ala Ile Tyr Arg Tyr Val
1985                1990                1995                2000
Leu Lys Ala Tyr His Leu Asn Met Thr Ser Asn Phe Leu Leu Asn Phe
                2005                2010                2015    
Gly Cys Ser Asn Gln Arg Glu Ile Trp Pro Ser Val Val Phe Thr Gly
            2020                2025                2030        
Ile Pro Arg Thr His Phe Pro Gln Asn Trp Gly Asn Pro Arg Lys Ala
        2035                2040                2045            
Pro Thr Ala His Thr Pro Arg Trp Tyr Val Pro Tyr Val Ile Leu Gly
    2050                2055                2060                
Ser Gln Thr Gln Ala Met Ala Ser Ile Tyr Gln Thr His Thr Val Cys
2065                2070                2075                2080
Gln Ala Leu Leu Leu Thr Leu Thr Leu Ser Pro Gln Leu Gln Gln Ser
                2085                2090                2095    
Leu Leu Arg Ser Ala Gly Leu Leu Cys Val Arg Lys Gly Pro Ser Ala
            2100                2105                2110        
Ser Leu Val Met Gly Leu Ala Glu Glu Asp Val Arg Ser Gly Val Ile
        2115                2120                2125            
Lys Ser Ser Ser Leu Ile Leu Glu Met Gln Cys Val Phe Lys Trp Ile
    2130                2135                2140                
Gly Phe Thr Lys Gln Trp Met Ile Val Leu His Lys Leu Leu Trp Thr
2145                2150                2155                2160
Gln Gln Gln Val Gly Ala Asn Gln Gly Thr Leu Pro Ser Ala Ile Val
                2165                2170                2175    
Glu Ala Phe Pro Gly Ala Phe Gly Phe Trp Leu Gln Ser Lys Val Lys
            2180                2185                2190        
Asp Asn Trp Asn Glu Val Pro Pro Thr Leu Thr Lys Glu His Gly Ala
        2195                2200                2205            
Thr Ser His Gln Lys Pro Thr Leu Arg Leu Thr Lys Lys Ser Lys Leu
    2210                2215                2220                
Val Leu Gln Leu Leu Thr Ser Gly Pro Ala Asn Gln Leu
2225                2230                2235        


<210> 2964
<211> 1154
<212> PRT
<213> Homo sapiens

<400> 2964
Met Ala Pro Gln Met Tyr Glu Phe His Leu Pro Leu Ser Pro Glu Glu
 1               5                  10                  15      
Leu Leu Lys Ser Gly Gly Val Asn Gln Tyr Val Val Gln Glu Val Leu
            20                  25                  30          
Ser Ile Lys His Leu Pro Pro Gln Leu Arg Ala Phe Gln Ala Ala Phe
        35                  40                  45              
Arg Ala Gln Gly Pro Leu Ala Met Leu Gln His Phe Asp Thr Ile Tyr
    50                  55                  60                  
Ser Ile Leu His His Phe Arg Ser Ile Asp Pro Gly Leu Lys Glu Asp
65                  70                  75                  80  
Thr Leu Gln Phe Leu Ile Lys Val Val Ser Arg His Ser Gln Glu Leu
                85                  90                  95      
Pro Ala Ile Leu Asp Asp Thr Thr Leu Ser Gly Ser Asp Arg Asn Ala
            100                 105                 110         
His Leu Asn Ala Leu Lys Met Asn Cys Tyr Ala Leu Ile Arg Leu Leu
        115                 120                 125             
Glu Ser Phe Glu Thr Met Ala Ser Gln Thr Asn Leu Val Asp Leu Asp
    130                 135                 140                 
Leu Gly Gly Lys Gly Lys Lys Ala Arg Thr Lys Ala Ala His Gly Phe
145                 150                 155                 160 
Asp Trp Glu Glu Glu Arg Gln Pro Ile Leu Gln Leu Leu Thr Gln Leu
                165                 170                 175     
Leu Gln Leu Asp Ile Arg His Leu Trp Asn His Ser Ile Ile Glu Glu
            180                 185                 190         
Glu Phe Val Ser Leu Val Thr Gly Cys Cys Tyr Arg Leu Leu Glu Asn
        195                 200                 205             
Pro Thr Ile Asn His Gln Lys Asn Arg Pro Thr Arg Glu Ala Ile Thr
    210                 215                 220                 
His Leu Leu Gly Val Ala Leu Thr Arg Tyr Asn His Met Leu Ser Ala
225                 230                 235                 240 
Thr Val Lys Ile Ile Gln Met Leu Gln His Phe Glu His Leu Ala Pro
                245                 250                 255     
Val Leu Val Ala Ala Val Ser Leu Trp Ala Thr Asp Tyr Gly Met Lys
            260                 265                 270         
Ser Ile Val Gly Glu Ile Val Arg Glu Ile Gly Gln Lys Cys Pro Gln
        275                 280                 285             
Glu Leu Ser Arg Asp Pro Ser Gly Thr Lys Gly Phe Ala Ala Phe Leu
    290                 295                 300                 
Thr Glu Leu Ala Glu Arg Val Pro Ala Ile Leu Met Ser Ser Met Cys
305                 310                 315                 320 
Ile Leu Leu Asp His Leu Asp Gly Glu Asn Tyr Met Met Arg Asn Ala
                325                 330                 335     
Val Leu Ala Ala Met Ala Glu Met Val Leu Gln Val Leu Ser Gly Asp
            340                 345                 350         
Gln Leu Glu Ala Ala Ala Arg Asp Thr Arg Asp Gln Phe Leu Asp Thr
        355                 360                 365             
Leu Gln Ala His Gly His Asp Val Asn Ser Phe Val Arg Ser Arg Val
    370                 375                 380                 
Leu Gln Leu Phe Thr Arg Ile Val Gln Gln Lys Ala Leu Pro Leu Thr
385                 390                 395                 400 
Arg Phe Gln Ala Val Val Ala Leu Ala Val Gly Arg Leu Ala Asp Lys
                405                 410                 415     
Ser Val Leu Val Cys Lys Asn Ala Ile Gln Leu Leu Ala Ser Phe Leu
            420                 425                 430         
Ala Asn Asn Pro Phe Ser Cys Lys Leu Ser Asp Ala Asp Leu Ala Gly
        435                 440                 445             
Pro Leu Gln Lys Glu Thr Gln Lys Leu Gln Glu Met Arg Ala Gln Arg
    450                 455                 460                 
Arg Thr Ala Ala Ala Ser Ala Val Leu Asp Pro Glu Glu Glu Trp Glu
465                 470                 475                 480 
Ala Met Leu Pro Glu Leu Lys Ser Thr Leu Gln Gln Leu Leu Gln Leu
                485                 490                 495     
Pro Gln Gly Glu Glu Glu Ile Pro Glu Gln Ile Ala Asn Thr Glu Thr
            500                 505                 510         
Thr Glu Asp Val Lys Gly Arg Ile Tyr Gln Leu Leu Ala Lys Ala Ser
        515                 520                 525             
Tyr Lys Lys Ala Ile Ile Leu Thr Arg Glu Ala Thr Gly His Phe Gln
    530                 535                 540                 
Glu Ser Glu Pro Phe Ser His Ile Asp Pro Glu Glu Ser Glu Glu Thr
545                 550                 555                 560 
Arg Leu Leu Asn Ile Leu Gly Leu Ile Phe Lys Gly Pro Ala Ala Ser
                565                 570                 575     
Thr Gln Glu Lys Asn Pro Arg Glu Ser Thr Gly Asn Met Val Thr Gly
            580                 585                 590         
Gln Thr Val Cys Lys Asn Lys Pro Asn Met Ser Asp Pro Glu Glu Ser
        595                 600                 605             
Arg Gly Asn Asp Glu Leu Val Lys Gln Glu Met Leu Val Gln Tyr Leu
    610                 615                 620                 
Gln Asp Ala Tyr Ser Phe Ser Arg Lys Ile Thr Glu Ala Ile Gly Ile
625                 630                 635                 640 
Ile Ser Lys Met Met Tyr Glu Asn Thr Thr Thr Val Val Gln Glu Val
                645                 650                 655     
Ile Glu Phe Phe Val Met Val Phe Gln Phe Gly Val Pro Gln Ala Leu
            660                 665                 670         
Phe Gly Val Arg Arg Met Leu Pro Leu Ile Trp Ser Lys Glu Pro Gly
        675                 680                 685             
Val Arg Glu Ala Val Leu Asn Ala Tyr Arg Gln Leu Tyr Leu Asn Pro
    690                 695                 700                 
Lys Gly Asp Ser Ala Arg Ala Lys Ala Gln Ala Leu Ile Gln Asn Leu
705                 710                 715                 720 
Ser Leu Leu Leu Val Asp Ala Ser Val Gly Thr Ile Gln Cys Leu Glu
                725                 730                 735     
Glu Ile Leu Cys Glu Phe Val Gln Lys Asp Glu Leu Lys Pro Ala Val
            740                 745                 750         
Thr Gln Leu Leu Trp Glu Arg Ala Thr Glu Lys Val Ala Cys Cys Pro
        755                 760                 765             
Leu Glu Arg Cys Ser Ser Val Met Leu Leu Gly Met Met Ala Arg Gly
    770                 775                 780                 
Lys Pro Glu Ile Val Gly Ser Asn Leu Asp Thr Leu Val Ser Ile Gly
785                 790                 795                 800 
Leu Asp Glu Lys Phe Pro Gln Asp Tyr Arg Leu Ala Gln Gln Val Cys
                805                 810                 815     
His Ala Ile Ala Asn Ile Ser Asp Arg Arg Lys Pro Ser Leu Gly Lys
            820                 825                 830         
Arg His Pro Pro Phe Arg Leu Pro Gln Glu His Arg Leu Phe Glu Arg
        835                 840                 845             
Leu Arg Glu Thr Val Thr Lys Gly Phe Val His Pro Asp Pro Leu Trp
    850                 855                 860                 
Ile Pro Phe Lys Glu Val Ala Val Thr Leu Ile Tyr Gln Leu Ala Glu
865                 870                 875                 880 
Gly Pro Glu Val Ile Cys Ala Gln Ile Leu Gln Gly Cys Ala Lys Gln
                885                 890                 895     
Ala Leu Glu Lys Leu Glu Glu Lys Arg Thr Ser Gln Glu Asp Pro Lys
            900                 905                 910         
Glu Ser Pro Ala Met Leu Pro Thr Phe Leu Leu Met Asn Leu Leu Ser
        915                 920                 925             
Leu Ala Gly Asp Val Ala Leu Gln Gln Leu Val His Leu Glu Gln Ala
    930                 935                 940                 
Val Ser Gly Glu Leu Cys Arg Arg Arg Val Leu Arg Glu Glu Gln Glu
945                 950                 955                 960 
His Lys Thr Lys Asp Pro Lys Glu Lys Asn Thr Ser Ser Glu Thr Thr
                965                 970                 975     
Met Glu Glu Glu Leu Gly Leu Val Gly Ala Thr Ala Asp Asp Thr Glu
            980                 985                 990         
Ala Glu Leu Ile Arg Gly Ile Cys Glu Met Glu Leu Leu Asp Gly Lys
        995                 1000                1005            
Gln Thr Leu Ala Ala Phe Val Pro Leu Leu Leu Lys Val Cys Asn Asn
    1010                1015                1020                
Pro Gly Leu Tyr Ser Asn Pro Asp Leu Ser Ala Ala Ala Ser Leu Ala
1025                1030                1035                1040
Leu Gly Lys Phe Cys Met Ile Ser Ala Thr Phe Cys Asp Ser Gln Leu
                1045                1050                1055    
Arg Leu Leu Phe Thr Met Leu Glu Lys Ser Pro Leu Pro Ile Val Arg
            1060                1065                1070        
Ser Asn Leu Met Val Ala Thr Gly Asp Leu Ala Ile Arg Phe Pro Asn
        1075                1080                1085            
Leu Val Asp Pro Trp Thr Pro His Leu Tyr Ala Arg Ser Pro Gly Pro
    1090                1095                1100                
Cys Ser Ala Ser Ala Glu Asn Ser Gly Ala Gly Asp Asp Pro Pro Asp
1105                1110                1115                1120
Pro Gln Gly His Gly Glu Gly Glu Gly Ala Gly Gln Arg Asp Gly Gly
                1125                1130                1135    
Ala Ala His Arg Pro Arg Ala Ser Asp Cys Cys Pro Gly Gln Glu Leu
            1140                1145                1150        
Leu Gln
        


<210> 2965
<211> 137
<212> PRT
<213> Homo sapiens

<400> 2965
Met Gln Cys Gly Leu Val Gly Lys Ile Ile Lys Arg Phe Glu Gln Lys
 1               5                  10                  15      
Gly Phe Arg Leu Val Ala Met Lys Phe Leu Pro Ala Ser Glu Glu His
            20                  25                  30          
Leu Lys Gln His Tyr Ile Asp Leu Lys Asp Arg Pro Phe Phe Pro Gly
        35                  40                  45              
Leu Val Lys Tyr Met Asn Ser Gly Pro Val Val Ala Met Val Trp Glu
    50                  55                  60                  
Gly Leu Asn Val Val Lys Thr Gly Arg Val Met Leu Gly Glu Thr Asn
65                  70                  75                  80  
Pro Ala Asp Ser Lys Pro Gly Thr Ile Arg Gly Asp Phe Cys Ile Gln
                85                  90                  95      
Val Gly Arg Asn Ile Ile His Gly Ser Asp Ser Val Lys Ser Ala Glu
            100                 105                 110         
Lys Glu Ile Ser Leu Arg Phe Lys Pro Glu Glu Leu Val Asp Tyr Lys
        115                 120                 125             
Ser Cys Ala His Asp Trp Val Tyr Glu
    130                 135         


<210> 2966
<211> 131
<212> PRT
<213> Homo sapiens

<400> 2966
Met Glu Asp Gly Thr Gly His Arg Ala Val Gly Leu Ala Cys Arg Pro
 1               5                  10                  15      
Arg Thr Leu Thr Val Cys Cys Pro Gly Gly Ala Ser Gln Ala Gln His
            20                  25                  30          
Leu Gly Ser Ile Gly Cys Leu Arg Glu Val Glu Gly Gly Ser Pro Ala
        35                  40                  45              
Val Val Leu Leu Asp Val Pro His Gly Val Gly Ser Ser Gly Gly Leu
    50                  55                  60                  
Gln Gln Cys His Arg Ala Ala Thr Glu Ala Thr Ala Arg His Ala Ala
65                  70                  75                  80  
Ala Ile Asn Pro Arg His Ser Lys Arg Ser Leu His Gln Leu Val Gln
                85                  90                  95      
Leu Trp Ala Ala His Leu Ile Val Val Ser Ala Glu Arg Ile Leu Lys
            100                 105                 110         
Gly Trp Ala Trp Ala Gly Leu Cys Pro Ala Gly Ala Gly Arg Pro Glu
        115                 120                 125             
Gly Leu Thr
    130     


<210> 2967
<211> 116
<212> PRT
<213> Homo sapiens

<400> 2967
Met Lys Pro Ser Asp Trp Pro Thr Ala Pro Arg Phe Val Thr Thr Leu
 1               5                  10                  15      
Pro Arg Ala Pro Pro Leu Pro Glu Ala Pro Ala His Ser Pro Ala Gly
            20                  25                  30          
Gly Pro Lys Ser Ala Glu Ser Arg Leu Glu Gly Gly Gly Ala Glu Leu
        35                  40                  45              
Ala Gly Ser Trp Lys Ala Arg Glu Thr Leu Phe Pro Pro Gly Arg Pro
    50                  55                  60                  
Asp Asp Arg Asp Trp Ala Gly Gly Arg Gly Gly Ala Pro His Leu Gly
65                  70                  75                  80  
Pro His Leu Phe Phe Met Pro Ile Leu Gln Val His Ala Pro Phe Leu
                85                  90                  95      
Leu Ser Arg Gln Pro Arg Leu Arg Leu Lys Ser Ala Ser Ala Leu Ile
            100                 105                 110         
Cys Leu Ser Leu
        115     


<210> 2968
<211> 171
<212> PRT
<213> Homo sapiens

<400> 2968
Met Asp Thr Glu Lys His Asn Glu Thr Ser Pro His Gln Thr Leu Asp
 1               5                  10                  15      
Thr Tyr Leu Ser Gln Glu Arg Ser Ser Pro Gly Val Gly Asp Ile Phe
            20                  25                  30          
Glu Thr Lys Arg Val Gly Leu His Arg Arg Leu Pro Pro Val Cys Thr
        35                  40                  45              
Asp Gln Thr Leu Ile Gly Leu Tyr Ile Tyr His Gly Glu Leu Arg Thr
    50                  55                  60                  
Ser Lys Gln Ala Trp Ala Ala Ala Ser Ala Glu Glu Ala Leu Pro Ser
65                  70                  75                  80  
Pro Pro Pro Pro Gly Pro Cys Arg Val Cys Gly Gly Gly Arg Gly Tyr
                85                  90                  95      
Leu Asp Ile Phe Ile Ser Arg Glu Leu Asp Arg Glu Arg Ile Ala Arg
            100                 105                 110         
Phe Pro Pro Asp Gly Ala Thr Ser Arg Arg Pro Gln Gly Pro Arg Ala
        115                 120                 125             
Gly Arg Trp Val Arg Phe Pro Ala Val Leu Leu Trp Pro Pro Trp Arg
    130                 135                 140                 
Ser Phe Tyr Asp Thr Leu Pro Val Phe Pro Asp Ile Ile Pro His Arg
145                 150                 155                 160 
Ser Val Leu Pro Thr Ser Arg Ser Ser Arg Pro
                165                 170     


<210> 2969
<211> 574
<212> PRT
<213> Homo sapiens

<400> 2969
Met Ala Ser Thr Glu Gly Ala Asn Asn Met Pro Lys Gln Val Glu Val
 1               5                  10                  15      
Arg Met His Asp Ser His Leu Gly Ser Glu Glu Pro Lys His Arg His
            20                  25                  30          
Leu Gly Leu Arg Leu Cys Asp Lys Leu Gly Lys Asn Leu Leu Leu Thr
        35                  40                  45              
Leu Thr Val Phe Gly Val Ile Leu Gly Ala Val Cys Gly Gly Leu Leu
    50                  55                  60                  
Arg Leu Ala Ser Pro Ile His Pro Asp Val Val Met Leu Ile Ala Phe
65                  70                  75                  80  
Pro Gly Asp Ile Leu Met Arg Met Leu Lys Met Leu Ile Leu Pro Leu
                85                  90                  95      
Ile Ile Ser Ser Leu Ile Thr Gly Leu Ser Gly Leu Asp Ala Lys Ala
            100                 105                 110         
Ser Gly Arg Leu Gly Thr Arg Ala Met Val Tyr Tyr Met Ser Thr Thr
        115                 120                 125             
Ile Ile Ala Ala Val Leu Gly Val Ile Leu Val Leu Ala Ile His Pro
    130                 135                 140                 
Gly Asn Pro Lys Leu Lys Lys Gln Leu Gly Pro Gly Lys Lys Asn Asp
145                 150                 155                 160 
Glu Val Ser Ser Leu Asp Ala Phe Leu Asp Leu Ile Arg Asn Leu Phe
                165                 170                 175     
Pro Glu Asn Leu Val Gln Ala Cys Phe Gln Gln Ile Gln Thr Val Thr
            180                 185                 190         
Lys Lys Val Leu Val Ala Pro Pro Pro Asp Glu Glu Ala Asn Ala Thr
        195                 200                 205             
Ser Ala Val Val Ser Leu Leu Asn Glu Thr Val Thr Glu Val Pro Glu
    210                 215                 220                 
Glu Thr Lys Met Val Ile Lys Lys Gly Leu Glu Phe Lys Asp Gly Met
225                 230                 235                 240 
Asn Val Leu Gly Leu Ile Gly Phe Phe Ile Ala Phe Gly Ile Ala Met
                245                 250                 255     
Gly Lys Met Gly Asp Gln Ala Lys Leu Met Val Asp Phe Phe Asn Ile
            260                 265                 270         
Leu Asn Glu Ile Val Met Lys Leu Val Ile Met Ile Met Trp Tyr Ser
        275                 280                 285             
Pro Leu Gly Ile Ala Cys Leu Ile Cys Gly Lys Ile Ile Ala Ile Lys
    290                 295                 300                 
Asp Leu Glu Val Val Ala Arg Gln Leu Gly Met Tyr Met Val Thr Val
305                 310                 315                 320 
Ile Ile Gly Leu Ile Ile His Gly Gly Ile Phe Leu Pro Leu Ile Tyr
                325                 330                 335     
Phe Val Val Thr Arg Lys Asn Pro Phe Ser Phe Phe Ala Gly Ile Phe
            340                 345                 350         
Gln Ala Trp Ile Thr Ala Leu Gly Thr Ala Ser Ser Ala Gly Thr Leu
        355                 360                 365             
Pro Val Thr Phe Arg Cys Leu Glu Glu Asn Leu Gly Ile Asp Lys Arg
    370                 375                 380                 
Val Thr Arg Phe Val Leu Pro Val Gly Ala Thr Ile Asn Met Asp Gly
385                 390                 395                 400 
Thr Ala Leu Tyr Glu Ala Val Ala Ala Ile Phe Ile Ala Gln Met Asn
                405                 410                 415     
Gly Val Val Leu Asp Gly Gly Gln Ile Val Thr Val Ser Leu Thr Ala
            420                 425                 430         
Thr Leu Ala Ser Val Gly Ala Ala Ser Ile Pro Ser Ala Gly Leu Val
        435                 440                 445             
Thr Met Leu Leu Ile Leu Thr Ala Val Gly Leu Pro Thr Glu Asp Ile
    450                 455                 460                 
Ser Leu Leu Val Ala Val Asp Trp Leu Leu Asp Arg Met Arg Thr Ser
465                 470                 475                 480 
Val Asn Val Val Gly Asp Ser Phe Gly Ala Gly Ile Val Tyr His Leu
                485                 490                 495     
Ser Lys Ser Glu Leu Asp Thr Ile Asp Ser Gln His Arg Val His Glu
            500                 505                 510         
Asp Ile Glu Met Thr Lys Thr Gln Ser Ile Tyr Asp Asp Met Lys Asn
        515                 520                 525             
His Arg Glu Ser Asn Ser Asn Gln Cys Val Tyr Ala Ala His Asn Ser
    530                 535                 540                 
Val Ile Val Asp Glu Cys Lys Val Thr Leu Ala Ala Asn Gly Lys Ser
545                 550                 555                 560 
Ala Asp Cys Ser Val Glu Glu Glu Pro Trp Lys Arg Glu Lys
                565                 570                 


<210> 2970
<211> 106
<212> PRT
<213> Homo sapiens

<400> 2970
Met Pro Ala Arg Lys Gly Ala Leu Trp Pro Arg Pro Arg Ser Cys Gly
 1               5                  10                  15      
Thr Ala Gly Ser Gly Ala Glu Gly Ser Arg Gly Gln Leu Ser Pro Gln
            20                  25                  30          
Arg Thr Gly Lys Gly Thr Leu Ser Arg Pro Gly Leu Pro Leu Tyr Leu
        35                  40                  45              
Cys Trp Gly Leu Val Val Arg Leu Arg Ser Ser Glu Leu Leu Gly Val
    50                  55                  60                  
Ala Gly Ala Ala Ile Pro Ser Ser Arg Arg Arg Ala Gln Gly Ala Ala
65                  70                  75                  80  
Arg Gly Ala Gly Thr Pro Gly Gln Arg Arg Ala Leu Ala Gln Pro Arg
                85                  90                  95      
Gly Cys Cys Trp Pro Ser Arg Leu Gln Gly
            100                 105     


<210> 2971
<211> 234
<212> PRT
<213> Homo sapiens

<400> 2971
Met Thr Glu Met Glu Gln Leu Tyr Leu Phe Asp Asp Phe Ser Arg Trp
 1               5                  10                  15      
Met Met Leu Lys Asn Leu Thr Lys Gln Gly Arg Ile Lys His Pro Asn
            20                  25                  30          
Pro Asn Ala His Pro Arg Pro Thr Ser Gln Asp Leu Ala Gly Phe Trp
        35                  40                  45              
Asp Met Leu Gln Leu Ser Ile Glu Asn Ile Ser Met Lys Phe Asp Glu
    50                  55                  60                  
Leu His Gln Leu Lys Ala Asn Asn Trp Lys Gln Met Asp Pro Leu Asp
65                  70                  75                  80  
Lys Lys Asn Pro Asn Ala His Pro Arg Pro Thr Ser Gln Asp Leu Ala
                85                  90                  95      
Gly Phe Trp Asp Met Leu Gln Leu Ser Ile Glu Asn Ile Ser Met Lys
            100                 105                 110         
Phe Asp Glu Leu His Gln Leu Lys Ala Asn Asn Trp Lys Gln Met Asp
        115                 120                 125             
Pro Leu Asp Lys Lys Glu Thr Ser Leu Ile Phe Tyr Gln Pro His Leu
    130                 135                 140                 
Thr Ala Val Asp Cys Ile Ala Arg Thr Gln Ala Ser Phe Gln Thr Val
145                 150                 155                 160 
Ile Leu Asn Glu Leu Asp Asp Asp Ser Tyr Phe Leu Val Asp Thr Glu
                165                 170                 175     
Leu Arg Thr Leu Ser Cys Leu Ala Asp Gly Lys Gln Ala His Pro Ala
            180                 185                 190         
Leu Trp Arg Gly Gly Ala Glu Glu Ser Pro Leu Pro Val His Ser Gly
        195                 200                 205             
His Thr Gly Glu Thr Cys Lys Ser Gly Leu Ala Val Gln Ile Arg Ala
    210                 215                 220                 
His Cys Gln Ala Gly Ser Ile Gly Gln Ala
225                 230                 


<210> 2972
<211> 386
<212> PRT
<213> Homo sapiens

<400> 2972
Met Ala Ala Arg His Leu Gly Ala Pro Gly Ala Leu Ala Ala Val Leu
 1               5                  10                  15      
Gly Thr Pro Ala Leu Pro Arg Arg Arg Ser Arg Pro Leu Met Asn Phe
            20                  25                  30          
Asp Arg Pro Ala Asn Ser Gly Arg Arg Leu Lys Glu Tyr Gly Ile Pro
        35                  40                  45              
Asn Ser His Leu Val Arg Leu Gly Lys Leu Ala Val Ser Glu Lys Leu
    50                  55                  60                  
Ala Thr Ser Gln Pro His Ser Ser Ser Ser Pro Asp Arg Ala His Ala
65                  70                  75                  80  
His Ser Pro Trp Thr Leu Glu Arg Arg Leu Gly Ile Ser Phe Leu Leu
                85                  90                  95      
Leu Ser Ser Arg Asp Arg Ala Ala Leu Trp Lys Pro Ser His Ser Ile
            100                 105                 110         
Ile Ala Glu Asp Pro Pro Pro Arg His Ser Glu Lys Val Pro Leu Arg
        115                 120                 125             
Pro Trp Pro Gly Arg Gly Ala Arg Arg Lys Arg Glu Ser Pro Arg Pro
    130                 135                 140                 
Arg Pro Pro Pro Leu Cys Pro Leu Ser Ala Ala Ala Ser Glu Gln Pro
145                 150                 155                 160 
Arg Ala Ala Leu His Ser Glu Arg Gly Ala Arg Arg Arg Gln Leu Gly
                165                 170                 175     
Ser Gly Phe Gly Leu Arg Gly Asp Arg Ala Ala Ala Pro Pro Thr Ala
            180                 185                 190         
Arg Ala Pro Met Ser Asn Ser Arg Asn Asn Arg Val Met Val Glu Gly
        195                 200                 205             
Val Gly Ala Arg Val Val Arg Gly Pro Asp Trp Lys Trp Gly Lys Gln
    210                 215                 220                 
Asp Gly Gly Glu Gly His Val Gly Thr Val Arg Ser Phe Glu Ser Pro
225                 230                 235                 240 
Glu Glu Val Val Val Val Trp Asp Asn Gly Thr Ala Ala Asn Tyr Arg
                245                 250                 255     
Cys Ser Gly Ala Tyr Asp Leu Arg Ile Leu Asp Ser Ala Pro Thr Gly
            260                 265                 270         
Lys Pro Arg Pro Pro Gly Gln Gly Leu Arg Ala Arg Gly Glu Gly Ala
        275                 280                 285             
Ser Cys Gly Gly Arg Arg Cys Arg Gly Glu Arg Ser Ala Val Gly His
    290                 295                 300                 
Leu Val Gly Ser Ala Arg Leu Glu Arg Ala Glu Arg Gln Ser Ala Lys
305                 310                 315                 320 
Gly Ile Leu Gly Ser Glu Arg Val Asn Lys His Phe Gln Lys Arg Pro
                325                 330                 335     
Ser Thr Pro Lys Gly Asn Asp Gly Ser Thr Ile Thr Gly Met Leu Ser
            340                 345                 350         
Ser Leu Glu Asp Thr Lys His Arg Glu Glu Asn Arg His Arg Ser Pro
        355                 360                 365             
Asn Pro Thr Pro Pro Leu Gly Lys Gly Ser Gly Glu Ala Tyr Leu Ile
    370                 375                 380                 
Ser His
385     


<210> 2973
<211> 636
<212> PRT
<213> Homo sapiens

<400> 2973
Met Glu Arg Ala Gly Leu Gln Arg Lys Gly Gly Ile Lys Lys Arg Ala
 1               5                  10                  15      
Trp Pro Leu Asp Phe Leu Met Pro Gly Ser Trp Asp Gly Pro Pro Gly
            20                  25                  30          
Leu His Arg Arg Thr Gly Arg Pro Ser Gly Asp Gly Glu Met Leu Pro
        35                  40                  45              
Gly Val Ser Arg Leu His Thr Ala Arg Val Leu Val Leu Gly Asp Asp
    50                  55                  60                  
Arg Met Leu Gly Arg Leu Ala Gln Ala Tyr His Arg Leu Arg Leu Ser
65                  70                  75                  80  
Leu Gln Leu Tyr Tyr Ile Pro Val Leu Ala Pro Glu Lys Pro Ala Ala
                85                  90                  95      
Ser Arg Gln Pro Glu Leu Gly Glu Leu Ala Thr Phe Leu Gly Arg Val
            100                 105                 110         
Asp Pro Trp Tyr Gln Ser Asn Val Asn Thr Leu Cys Pro Ala Ile His
        115                 120                 125             
Lys Leu Ala Glu Met Pro Pro Ser Leu Asp Thr Ser Arg Thr Val Asp
    130                 135                 140                 
Pro Phe Ile Leu Asp Val Ile Thr Tyr Tyr Ile Arg Met Gly Thr Gln
145                 150                 155                 160 
Pro Ile Tyr Phe Gln Ile Tyr Thr Val Lys Ile Phe Phe Ser Asp Leu
                165                 170                 175     
Ser Gln Asp Pro Thr Glu Asp Ile Phe Leu Ile Glu Leu Lys Val Lys
            180                 185                 190         
Ile Gln Asp Ser Lys Phe Pro Lys Asp Gly Phe Ser Pro Arg Arg Arg
        195                 200                 205             
Gly Val Ala Glu Gly Pro Gly Ala Glu Leu Ser Leu Cys Tyr Gln Lys
    210                 215                 220                 
Ala Leu Leu Ser His Arg Pro Arg Glu Val Thr Val Ser Leu Arg Ala
225                 230                 235                 240 
Thr Gly Leu Ile Leu Lys Ala Ile Pro Ala Ser Asp Thr Glu Gly Ala
                245                 250                 255     
Gly Glu Thr Thr Gln Val Thr Val Ala Leu Val Pro Ala Arg Glu Gly
            260                 265                 270         
Gly Lys Ser Ser Gln Ser Trp Asn Ser Ser Ala Glu Arg Arg Asp Trp
        275                 280                 285             
Leu Pro Leu Pro Gln Thr Cys Pro Pro Ala Pro Pro Ser Pro Pro Ala
    290                 295                 300                 
Gly Pro Lys Pro Arg Phe Arg Arg Gly Gly Leu Thr Ser Pro Tyr Ser
305                 310                 315                 320 
Leu Gly Val Ala Gly Ala Pro Arg Trp Cys Pro Ser Gly His Cys His
                325                 330                 335     
Gly Pro Ala Arg Val Cys Phe Phe Arg Gly Leu Ala Gly Gln Ser Arg
            340                 345                 350         
Gly Cys Phe Ser Asp Ala Leu Arg Pro Arg Gly Arg Asp Pro Glu Asp
        355                 360                 365             
Val Gly Pro Gly Ala His Leu Ala Asp Ala Ala Gly Pro Pro Gly Gly
    370                 375                 380                 
Trp Arg Gly Arg Leu Arg Gly Ser Ala Pro Pro Ala Gly Gly Ala Gln
385                 390                 395                 400 
Ala Gly Gln Met Leu Arg Leu Ala Ala Arg Leu Gln Leu Gly Arg Gly
                405                 410                 415     
Gly Pro Asp Gly His Pro Asn Arg Arg Glu Ser Pro Leu Glu Arg Gly
            420                 425                 430         
Ser Ala Pro Gly Gly Asp Cys Arg Val Arg Ser Pro Ala Arg Ser Ser
        435                 440                 445             
Gly Glu Leu Ser Val Ser Val Gly Ile Arg Ala Leu Val Pro Ser Glu
    450                 455                 460                 
Pro Gly Ser His Gly Ser Ala Arg Phe Thr Lys Gly Pro Arg Leu Ile
465                 470                 475                 480 
Thr Pro Val Leu Glu Asn Met Thr Phe Cys Val Leu Ile Ser Leu Asp
                485                 490                 495     
Tyr Pro Gln His Ser Ser Leu Trp Glu Glu Ala Val Val Arg Ser Lys
            500                 505                 510         
Leu Gly Val Val Met Asp Asn Glu Asn Cys Val Glu Asp Thr Gly Ser
        515                 520                 525             
Asp Ser Leu Ser Pro Arg Asn Ser Gln Pro Gln Phe Arg Asn Phe Arg
    530                 535                 540                 
Leu Gly Asp Phe Glu Ala Ala Ser Leu Ala Leu Val His Cys Asp Tyr
545                 550                 555                 560 
Arg Arg Asn Ser Asn Val Gln Glu Ala His Val Ser Arg Glu Val Leu
                565                 570                 575     
Leu Thr Ser His Lys Lys Gln Leu Met Thr Asp Ser Asp Gly Asn Glu
            580                 585                 590         
Arg Val Lys Gly Val Gly Gly Ser Gln Gly Leu Val Ala Gln Ala Ser
        595                 600                 605             
Pro Ala Ser Glu Lys Asn Leu Gly Arg Ala Arg Glu Ser Leu Gly Met
    610                 615                 620                 
Pro Gly Arg Leu Ala His Gln Asn Ser Thr Ser Ala
625                 630                 635     


<210> 2974
<211> 501
<212> PRT
<213> Homo sapiens

<400> 2974
Met Glu Lys Gly Ile Gln Phe Ser Pro Ser Gln Leu Gln Pro Arg Leu
 1               5                  10                  15      
Arg Glu Glu Leu Gly Lys Ala Gly Val Thr Leu Pro Arg Phe Ala Gly
            20                  25                  30          
Val Gly Val Gly Glu Gly Gly Arg Gly Thr Glu Glu Gly Lys Glu Glu
        35                  40                  45              
Glu Thr Glu Tyr Leu Ser Tyr Cys Ile Ser Lys Ala Lys Ala Phe Ser
    50                  55                  60                  
Lys Ala Pro Pro Gly Asn Val Cys Ser Arg Val Leu Asp Trp Ser Cys
65                  70                  75                  80  
Asp Asn Asp Gly Ala Cys Gln Pro Arg Ala Pro Ala Thr Ser Ala Asp
                85                  90                  95      
Arg Ala Ala Met Gly Ile Asp Glu Leu Val Ile Leu Ala Met Arg Arg
            100                 105                 110         
Ala Gly Thr His Ser Arg Ser Thr Phe Pro Gly Leu Lys Ser Leu Leu
        115                 120                 125             
Gly Val Ala Val Ala Gly Thr Val Gln Asp Arg Asp Leu Leu Leu Ile
    130                 135                 140                 
Gly Phe Asn Ala Leu Arg Leu Ala Leu Ser Val Trp Ala Glu Asn Leu
145                 150                 155                 160 
His Asn Asp Thr Asn Val Asp Gly His Ile Cys Val Ala Val Glu Ile
                165                 170                 175     
Lys Ser Leu Cys Pro Pro Trp Tyr Glu Tyr Ala Ser Ser Ile Tyr Ser
            180                 185                 190         
Tyr Trp Gly Ser Val His Leu Gln Arg Ser Ser Tyr Gln Ser Ser Pro
        195                 200                 205             
Pro Leu Leu Glu Arg Trp Ala Glu Ala Gln Ser Asp Cys Val Gly Glu
    210                 215                 220                 
Cys Asp Met Phe Leu Val Asp Ala Tyr Cys Glu Gly Cys Leu Gly Leu
225                 230                 235                 240 
Glu Pro Ser Glu Val Leu Asn Gln Leu Glu Glu Cys Glu Met Glu Arg
                245                 250                 255     
Glu Asp Lys Met Gln Lys Glu Ser Leu Trp Pro Arg Ala Gly Ala Glu
            260                 265                 270         
Gly Val Ile Lys Pro Thr Phe Pro Ser Pro Gly Asn Glu Asn Ile Cys
        275                 280                 285             
Leu Ser Val Leu Leu Thr Ala Lys Pro Arg Gly Leu Val Gln His His
    290                 295                 300                 
Cys Trp Ala Phe Leu Leu Leu Thr Ser Ser Glu Ser Lys Asp Thr Trp
305                 310                 315                 320 
Gln Ser Leu Pro Ser Glu Met Phe Pro Leu Ala Glu Pro Cys Pro Glu
                325                 330                 335     
Ser Arg Arg Leu Ala Arg Ala Glu Gly Ile Gly Met Ala Leu Thr Leu
            340                 345                 350         
Trp Val Pro His Arg Val Gln Gly Ile Phe Thr Val Asp Leu Gly Gly
        355                 360                 365             
Thr Trp Ser Ser Gly Ser Leu Thr Leu Ser Asn Gln Trp Gly Ser Arg
    370                 375                 380                 
Glu Arg Val Gln Gly Thr Phe Pro Asn Gly Arg Lys Ala Lys Pro Ser
385                 390                 395                 400 
Phe Gln Glu Ala Glu Gln Thr Ser Gln Glu Glu Ala Thr Gly Ser Leu
                405                 410                 415     
Ala Leu Trp Ala Thr Glu Glu Val Leu Gly Ile Arg Val Gln Cys Arg
            420                 425                 430         
Leu Ser Gly Ser Asn Leu Pro Tyr Asn Ala Cys Ser Ser His Leu Leu
        435                 440                 445             
Gly Leu Met Leu Val Leu Ile Phe Gly Glu Tyr Asn Val Pro Ile His
    450                 455                 460                 
Ala Lys Lys Asn Ser Glu Arg Lys Gly Asp Leu Lys Gln Lys Gln Lys
465                 470                 475                 480 
Gln Lys Thr Thr Leu Phe Phe Met Ala Gly Gly Ser Leu Ser Thr Ser
                485                 490                 495     
Leu Leu Glu Gly Asp
            500     


<210> 2975
<211> 93
<212> PRT
<213> Homo sapiens

<400> 2975
Met Lys Arg Gln Gly Lys Val Val Pro Glu Pro Met Arg Cys Ile Tyr
 1               5                  10                  15      
Gly Glu Gly Tyr Val Arg Ser Cys Asp Ala Glu Glu His Ser Tyr Phe
            20                  25                  30          
Gln Ala Thr Ala Gly Gln Glu Gly Asn His His Asp Phe Val Pro Phe
        35                  40                  45              
Arg Ile Gly Ile Ser Ser Val Lys Gln Lys Gln Ser Gln Asn Glu Gly
    50                  55                  60                  
Ser Ser Gly Val Met Gly Thr Ala Asp Asp Ile Lys Ser Leu Lys Leu
65                  70                  75                  80  
Arg Ile Val Asn Cys Leu Trp Val Gly Leu Glu Ser Ser
                85                  90              


<210> 2976
<211> 217
<212> PRT
<213> Homo sapiens

<400> 2976
Met Glu Thr Ile Trp Ile Tyr Gln Phe Arg Leu Ile Val Ile Gly Asp
 1               5                  10                  15      
Ser Thr Val Gly Lys Ser Cys Leu Leu His Arg Phe Thr Gln Gly Arg
            20                  25                  30          
Phe Pro Gly Leu Arg Ser Pro Ala Cys Asp Pro Thr Val Gly Val Asp
        35                  40                  45              
Phe Phe Ser Arg Leu Leu Glu Ile Glu Pro Gly Lys Arg Ile Lys Leu
    50                  55                  60                  
Gln Leu Trp Asp Thr Ala Gly Gln Glu Arg Phe Arg Ser Ile Thr Arg
65                  70                  75                  80  
Ser Tyr Tyr Arg Asn Ser Val Gly Gly Phe Leu Val Phe Asp Ile Thr
                85                  90                  95      
Asn Arg Arg Ser Phe Glu His Val Lys Asp Trp Leu Glu Glu Ala Lys
            100                 105                 110         
Met Tyr Val Gln Pro Phe Arg Ile Val Phe Leu Leu Val Gly His Lys
        115                 120                 125             
Cys Asp Leu Ala Ser Gln Arg Gln Val Thr Arg Glu Glu Ala Glu Lys
    130                 135                 140                 
Leu Ser Ala Asp Cys Gly Met Lys Tyr Ile Glu Thr Ser Ala Lys Asp
145                 150                 155                 160 
Ala Thr Asn Val Glu Glu Ser Phe Thr Ile Leu Thr Arg Asp Ile Tyr
                165                 170                 175     
Glu Leu Ile Lys Lys Gly Glu Ile Cys Ile Gln Asp Gly Trp Glu Gly
            180                 185                 190         
Val Lys Ser Gly Phe Val Pro Asn Thr Val His Ser Ser Glu Glu Ala
        195                 200                 205             
Val Lys Pro Arg Lys Glu Cys Phe Cys
    210                 215         


<210> 2977
<211> 728
<212> PRT
<213> Homo sapiens

<400> 2977
Met Cys Ala Ser Val Lys Tyr Asn Ile Arg Gly Pro Ala Leu Ile Pro
 1               5                  10                  15      
Arg Met Lys Thr Lys His Arg Ile Tyr Tyr Ile Thr Leu Phe Ser Ile
            20                  25                  30          
Val Leu Leu Gly Leu Ile Ala Thr Gly Val Phe Gln Phe Trp Pro His
        35                  40                  45              
Ser Ile Glu Ser Ser Asn Asp Trp Asn Val Glu Lys Arg Ser Ile Arg
    50                  55                  60                  
Asp Val Pro Val Val Arg Leu Pro Ala Asp Ser Pro Ile Pro Glu Arg
65                  70                  75                  80  
Gly Asp Leu Ser Cys Arg Met His Thr Cys Phe Asp Val Tyr Arg Cys
                85                  90                  95      
Gly Phe Asn Pro Lys Asn Lys Ile Lys Val Tyr Ile Tyr Ala Leu Lys
            100                 105                 110         
Lys Tyr Val Asp Asp Phe Gly Val Ser Val Ser Asn Thr Ile Ser Arg
        115                 120                 125             
Glu Tyr Asn Glu Leu Leu Met Ala Ile Ser Asp Ser Asp Tyr Tyr Thr
    130                 135                 140                 
Asp Asp Ile Asn Arg Ala Cys Leu Phe Val Pro Ser Ile Asp Val Leu
145                 150                 155                 160 
Asn Gln Asn Thr Leu Arg Ile Lys Glu Thr Ala Gln Ala Met Ala Gln
                165                 170                 175     
Leu Ser Arg Trp Asp Arg Gly Thr Asn His Leu Leu Phe Asn Met Leu
            180                 185                 190         
Pro Gly Gly Pro Pro Asp Tyr Asn Thr Ala Leu Asp Val Pro Arg Asp
        195                 200                 205             
Arg Ala Leu Leu Ala Gly Gly Gly Phe Ser Thr Trp Thr Tyr Arg Gln
    210                 215                 220                 
Gly Tyr Asp Val Ser Ile Pro Val Tyr Ser Pro Leu Ser Ala Glu Val
225                 230                 235                 240 
Asp Leu Pro Glu Lys Gly Pro Gly Pro Arg Gln Tyr Phe Leu Leu Ser
                245                 250                 255     
Ser Gln Val Gly Leu His Pro Glu Tyr Arg Glu Asp Leu Glu Ala Leu
            260                 265                 270         
Gln Val Lys His Gly Glu Ser Val Leu Val Leu Asp Lys Cys Thr Asn
        275                 280                 285             
Leu Ser Glu Gly Val Leu Ser Val Arg Lys Arg Cys His Lys His Gln
    290                 295                 300                 
Val Phe Asp Tyr Pro Gln Val Leu Gln Glu Ala Thr Phe Cys Val Val
305                 310                 315                 320 
Leu Arg Gly Ala Arg Leu Gly Gln Ala Val Leu Ser Asp Val Leu Gln
                325                 330                 335     
Ala Gly Cys Val Pro Val Val Ile Ala Asp Ser Tyr Ile Leu Pro Phe
            340                 345                 350         
Ser Glu Val Leu Asp Trp Lys Arg Ala Ser Val Val Val Pro Glu Glu
        355                 360                 365             
Lys Met Ser Asp Val Tyr Ser Ile Leu Gln Ser Ile Pro Gln Arg Gln
    370                 375                 380                 
Ile Glu Glu Met Gln Arg Gln Leu Phe Met Glu Pro Ala Arg Arg Glu
385                 390                 395                 400 
Asn Trp Ser Ala Ala Asn His Gln Met Asn Ser Leu Ile Trp Pro Arg
                405                 410                 415     
Glu Gln Trp Asp Ser Gln Ile Ile Asn Asp Arg Ile Tyr Pro Tyr Ala
            420                 425                 430         
Ala Ile Ser Tyr Glu Glu Trp Asn Asp Pro Pro Ala Val Lys Trp Gly
        435                 440                 445             
Ser Val Ser Asn Pro Leu Phe Leu Pro Leu Ile Pro Pro Gln Ser Gln
    450                 455                 460                 
Gly Phe Thr Ala Ile Val Leu Thr Tyr Asp Arg Val Glu Ser Leu Phe
465                 470                 475                 480 
Arg Val Ile Thr Glu Val Ser Lys Val Pro Ser Leu Ser Lys Leu Leu
                485                 490                 495     
Val Val Trp Asn Asn Gln Asn Lys Asn Pro Pro Glu Asp Ser Leu Trp
            500                 505                 510         
Pro Lys Ile Arg Val Pro Leu Lys Val Val Arg Thr Ala Glu Asn Lys
        515                 520                 525             
Leu Ser Asn Arg Phe Phe Pro Tyr Asp Glu Ile Glu Thr Glu Ala Val
    530                 535                 540                 
Leu Ala Ile Asp Asp Asp Ile Ile Met Leu Thr Ser Asp Glu Leu Gln
545                 550                 555                 560 
Phe Gly Tyr Glu Val Trp Arg Glu Phe Pro Asp Arg Leu Val Gly Tyr
                565                 570                 575     
Pro Gly Arg Leu His Leu Trp Asp His Glu Met Asn Lys Trp Lys Tyr
            580                 585                 590         
Glu Ser Glu Trp Thr Asn Glu Val Ser Met Val Leu Thr Gly Ala Ala
        595                 600                 605             
Phe Tyr His Lys Tyr Phe Asn Tyr Leu Tyr Thr Tyr Lys Met Pro Gly
    610                 615                 620                 
Asp Ile Lys Asn Trp Val Asp Ala His Met Asn Cys Glu Asp Ile Ala
625                 630                 635                 640 
Met Asn Phe Leu Val Ala Asn Val Thr Gly Lys Ala Val Ile Lys Val
                645                 650                 655     
Thr Pro Arg Lys Lys Phe Lys Cys Pro Glu Cys Thr Ala Ile Asp Gly
            660                 665                 670         
Leu Ser Leu Asp Gln Thr His Met Val Glu Arg Ser Glu Cys Ile Asn
        675                 680                 685             
Lys Phe Ala Ser Val Phe Gly Thr Met Pro Leu Lys Val Val Glu His
    690                 695                 700                 
Arg Ala Asp Pro Val Leu Tyr Lys Asp Asp Phe Pro Glu Lys Leu Lys
705                 710                 715                 720 
Ser Phe Pro Asn Ile Gly Ser Leu
                725             


<210> 2978
<211> 122
<212> PRT
<213> Homo sapiens

<400> 2978
Met Asn Leu Arg Leu His Ser Ala Leu Leu Arg Leu Ser Ser Ala Asn
 1               5                  10                  15      
Ala Cys Leu Leu Arg Leu Gly Ser Leu Arg Leu Ser Glu Ser Ala Pro
            20                  25                  30          
Val Val Ala Ser Ala Pro Leu Arg Leu Arg Ser Ala His Asp His Leu
        35                  40                  45              
Ser Leu Ser Ser Pro Arg Leu Arg Ser Ala Gly Cys Arg Pro Leu Gly
    50                  55                  60                  
Leu Gly Ser Leu Arg Leu Ser Ser Ala Tyr Ser Pro Leu Gly Val Gly
65                  70                  75                  80  
Phe Leu Arg Leu Arg Ser Ala Ala Thr Arg Lys Ser Phe His Gly Val
                85                  90                  95      
Arg Ala Ala Gly Ser Thr Asp Cys His Gly Ala Ala Ala Gly Val Arg
            100                 105                 110         
Ala Thr Ala Gly Ala Gly Thr Ala Arg His
        115                 120         


<210> 2979
<211> 131
<212> PRT
<213> Homo sapiens

<400> 2979
Met Ala Ser Pro Arg Ser Gln Thr Lys Glu Leu Glu Phe Asp Leu Glu
 1               5                  10                  15      
Gly Asp Gly Glu Pro Thr Gly Ala Leu Lys Gln Arg Ile Gly Arg Val
            20                  25                  30          
Ser Gln Cys Cys Gly Asn Ile Ile Trp Val Met Gly Met Glu Glu Lys
        35                  40                  45              
Ser Glu Gly Glu Ser Ile His Ala Ser Trp Leu Asp Lys Val Glu Arg
    50                  55                  60                  
Ala Gln Thr Leu Glu Leu Asp Val Gly Leu Ser Pro Asp Ser Ala Thr
65                  70                  75                  80  
His Gln Leu Phe Asp Pro Gly Leu Cys Pro Asp Gly Leu Ser His Val
                85                  90                  95      
Ala Asp Gly Gly Met Ser Gln Cys Pro Ser Lys Gly Glu Pro Ala Pro
            100                 105                 110         
Ala Gly Arg Ser Ser Ser Pro Ala Gln Ala Gly Ala Glu Leu Gly Thr
        115                 120                 125             
Asn Gln Asp
    130     


<210> 2980
<211> 91
<212> PRT
<213> Homo sapiens

<400> 2980
Met Ser Val Pro Leu Pro Leu Lys Ile Gln Val Ile Asp Cys Phe Thr
 1               5                  10                  15      
Tyr Tyr Ile Arg Lys Gly Tyr Glu Glu Ala Leu Arg Leu Ala Lys Ser
            20                  25                  30          
Ser Val Ala Ala Ser Thr Phe Leu Ala Thr Ala Ala Tyr Val His Pro
        35                  40                  45              
Phe Val Val Gln Asn Arg Phe Leu Pro Leu Leu Asn Thr Leu Gly Val
    50                  55                  60                  
Tyr Gly Phe Arg Arg Leu Thr His Ser Pro Ala Val Phe Asp Lys Ala
65                  70                  75                  80  
Pro Arg Gln Leu Pro Phe Tyr Pro Glu Arg Phe
                85                  90      


<210> 2981
<211> 289
<212> PRT
<213> Homo sapiens

<400> 2981
Met Gly Ser Met Val Ala Gly Cys Ile Arg Gly Ser Gly Glu Gly Val
 1               5                  10                  15      
Arg Pro Ser Arg Leu Gln Pro Arg Ser Ile Leu Trp Leu Gln Arg Ser
            20                  25                  30          
Arg Arg His Leu Pro Ser Pro Arg Pro Pro Arg Arg Ser Ala Pro Ser
        35                  40                  45              
Thr Leu His Pro Thr Pro Gly Ser Pro Gly Lys Ala Ala Pro Pro Gly
    50                  55                  60                  
Arg Ala Arg Leu Arg Val Leu Ala Gln Val Pro Asp Asp Gly Arg Val
65                  70                  75                  80  
Pro Ala Gly Thr Val Arg Ile Asp Trp Gly Leu Gly Glu Thr Lys Ala
                85                  90                  95      
Pro Lys Gly Pro Ser Leu Pro Asn Val Phe Phe Arg Arg Leu Asp Gly
            100                 105                 110         
Ser Pro Gln Ala Phe His Phe Gln Cys Thr Met Lys Lys Arg Ala Arg
        115                 120                 125             
Glu Pro Lys Met Gly Arg Ser Ile Gly Asn Val Lys Thr Lys Pro Gly
    130                 135                 140                 
Ala Ile Pro Asp Gly Cys Ala Ser Ser Leu Ser Leu Ala Phe Pro Asp
145                 150                 155                 160 
Leu Pro Pro Ile Pro Gln Arg Leu Gln Gln Pro Leu Pro Leu Gly Thr
                165                 170                 175     
Glu Val Cys Cys Lys Gly Leu Leu Ser Gln Cys Trp Arg Glu Lys Val
            180                 185                 190         
Thr Glu Val Asp Gly Ser Leu Glu Gly Ser His Leu Pro Ser Pro Gln
        195                 200                 205             
Leu Gly Met Glu Pro Leu Ala His Gly Thr Ile Met Glu Pro His Ile
    210                 215                 220                 
His Ser Val Leu Ala Leu Trp Leu Pro Arg Cys Leu Phe Phe Ser Ile
225                 230                 235                 240 
Asn Ser Glu Arg His Ser Ile Gly Glu Asp Ala Gly Phe Glu Pro Arg
                245                 250                 255     
Ile Ser Asp Ser Lys Thr His Ile Leu Asn His Lys Ala Met Cys Pro
            260                 265                 270         
Gly His Lys His Thr Pro Gly Ala Glu Met Glu Thr Thr Asp Ser Asn
        275                 280                 285             
Val
    


<210> 2982
<211> 339
<212> PRT
<213> Homo sapiens

<400> 2982
Met Ser Thr Val His Glu Ile Leu Cys Lys Leu Ser Leu Glu Gly Asp
 1               5                  10                  15      
His Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Ala Tyr Thr Asn
            20                  25                  30          
Phe Asp Ala Glu Arg Asp Ala Leu Asn Ile Glu Thr Ala Ile Lys Thr
        35                  40                  45              
Lys Gly Val Asp Glu Val Thr Ile Val Asn Ile Leu Thr Asn Arg Ser
    50                  55                  60                  
Asn Ala Gln Arg Gln Asp Ile Ala Phe Ala Tyr Gln Arg Arg Thr Lys
65                  70                  75                  80  
Lys Glu Leu Ala Ser Ala Leu Lys Ser Ala Leu Ser Gly His Leu Glu
                85                  90                  95      
Thr Val Ile Leu Gly Leu Leu Lys Thr Pro Ala Gln Tyr Asp Ala Ser
            100                 105                 110         
Glu Leu Lys Ala Ser Met Lys Gly Leu Gly Thr Asp Glu Asp Ser Leu
        115                 120                 125             
Ile Glu Ile Ile Cys Ser Arg Thr Asn Gln Glu Leu Gln Glu Ile Asn
    130                 135                 140                 
Arg Val Tyr Lys Glu Met Tyr Lys Thr Asp Leu Glu Lys Asp Ile Ile
145                 150                 155                 160 
Ser Asp Thr Ser Gly Asp Phe Arg Lys Leu Met Val Ala Leu Ala Lys
                165                 170                 175     
Gly Arg Arg Ala Glu Asp Gly Ser Val Ile Asp Tyr Glu Leu Ile Asp
            180                 185                 190         
Gln Asp Ala Arg Asp Leu Tyr Asp Ala Gly Val Lys Arg Lys Gly Thr
        195                 200                 205             
Asp Val Pro Lys Trp Ile Ser Ile Met Thr Glu Arg Ser Val Pro His
    210                 215                 220                 
Leu Gln Lys Val Phe Asp Arg Tyr Lys Ser Tyr Ser Pro Tyr Asp Met
225                 230                 235                 240 
Leu Glu Ser Ile Arg Lys Glu Val Lys Gly Asp Leu Glu Asn Ala Phe
                245                 250                 255     
Leu Asn Leu Val Gln Cys Ile Gln Asn Lys Pro Leu Tyr Phe Ala Asp
            260                 265                 270         
Arg Leu Tyr Asp Ser Met Lys Gly Lys Gly Thr Arg Asp Lys Val Leu
        275                 280                 285             
Ile Arg Ile Met Ala Ser Arg Ser Glu Val Asp Met Leu Lys Ile Arg
    290                 295                 300                 
Ser Glu Phe Lys Arg Lys Tyr Gly Lys Ser Leu Tyr Tyr Tyr Ile Gln
305                 310                 315                 320 
Gln Asp Thr Lys Gly Asp Tyr Gln Lys Ala Leu Leu Tyr Leu Cys Gly
                325                 330                 335     
Gly Asp Asp
            


<210> 2983
<211> 432
<212> PRT
<213> Homo sapiens

<400> 2983
Glu Ser Ala Gly Lys Arg Pro Arg Arg His Ser Arg Arg Thr Ala Ala
 1               5                  10                  15      
Ser Ser Gln Gly Phe Gly Ala Gly Cys Ala Gly Val Gly Pro Pro Gly
            20                  25                  30          
Thr Gly Arg Ala Leu Asn Arg His Arg Cys Gly Asp Trp Ser Arg Arg
        35                  40                  45              
Arg Lys Pro Gly Ser Pro Ala Leu Gly Val Gly Glu Gly Arg Ser Phe
    50                  55                  60                  
Ser Arg Asp Gly Asp Gly Tyr Trp Ala Ser Pro Gly Pro Gly Pro Ala
65                  70                  75                  80  
Arg Ala Thr Leu Gly Ala Arg Pro Arg Pro Ala Leu Gly Ala Ser Ala
                85                  90                  95      
Gln Ala Arg Leu Leu Arg Arg Gln Pro Ala Ala Pro Trp Leu Thr Ser
            100                 105                 110         
Ala Pro Ala Ser Ala Arg Gly Val Ala Ala Gly Pro Gly Asp Gly Gly
        115                 120                 125             
Arg Lys Arg Glu Arg Arg Arg Ala Gly Lys Thr Pro Arg Gly Thr Ala
    130                 135                 140                 
Arg Pro Pro His Pro Lys Val Ala Arg Pro Ala Arg Pro Leu Gly Arg
145                 150                 155                 160 
Arg Val Arg Thr Thr Gly Ile Gly Glu Arg Arg Arg Ser Tyr Tyr Pro
                165                 170                 175     
Gly Lys Ser Gly Glu Gln Trp Ser Gly Thr Leu Ser His Ala Ser Val
            180                 185                 190         
Gln Pro Gly Leu Arg Cys Glu Gly Gln Ala Pro Gln Glu Pro Gly Arg
        195                 200                 205             
Gly Ser Ser Gly Lys Leu His Leu Cys Ser Gly Lys Pro Leu Arg Lys
    210                 215                 220                 
Arg Ser Pro Cys Ser Arg Ser Val Pro Ala Pro Gly Gln Ser Arg Gly
225                 230                 235                 240 
Arg Arg Phe Thr Ser Ser Pro Pro Gly Leu Pro Ala Ser Pro Ser Pro
                245                 250                 255     
Cys Ile Thr Glu Arg Ser Lys Gln Lys Ala Arg Arg Arg Thr Arg Ser
            260                 265                 270         
Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser
        275                 280                 285             
Ser Ser Ser Ser Ser Ser Ser Ser Asp Gly Arg Lys Lys Arg Gly Lys
    290                 295                 300                 
Tyr Lys Asp Lys Arg Arg Lys Lys Lys Lys Lys Arg Lys Lys Leu Lys
305                 310                 315                 320 
Lys Lys Gly Lys Glu Lys Ala Glu Ala Gln Gln Val Glu Ala Leu Pro
                325                 330                 335     
Gly Pro Ser Leu Asp Gln Trp His Arg Ser Ala Gly Glu Glu Glu Asp
            340                 345                 350         
Gly Pro Val Leu Thr Asp Glu Gln Lys Ser Arg Ile Gln Ala Met Lys
        355                 360                 365             
Pro Met Thr Lys Glu Glu Trp Asp Ala Arg Gln Ser Ile Ile Arg Lys
    370                 375                 380                 
Val Val Asp Pro Glu Thr Gly Arg Thr Arg Leu Ile Lys Gly Asp Gly
385                 390                 395                 400 
Glu Val Leu Glu Glu Ile Val Thr Lys Glu Arg His Arg Glu Ile Asn
                405                 410                 415     
Lys Val Gly Val Ala Pro Leu Pro Ala Ile Arg Pro Gln Leu Cys Leu
            420                 425                 430         


<210> 2984
<211> 938
<212> PRT
<213> Homo sapiens

<400> 2984
Phe Pro Pro Tyr Phe Pro Ala Leu His Arg Phe Ile Leu Leu Tyr Gln
 1               5                  10                  15      
Ala Arg Arg Val Glu Asp Glu Ala Gln Gly Arg Glu Leu Val Phe Ala
            20                  25                  30          
Leu Trp Gln Gln Leu Gly Ala Val Leu Lys Asp Ile Thr Pro Glu Gly
        35                  40                  45              
Leu Glu Ile Leu Leu Pro Phe Val Leu Ser Leu Met Ser Glu Glu His
    50                  55                  60                  
Thr Ala Val Tyr Thr Ala Trp Tyr Leu Phe Glu Pro Val Ala Lys Ala
65                  70                  75                  80  
Leu Gly Pro Lys Asn Ala Asn Lys Tyr Leu Leu Lys Pro Leu Ile Gly
                85                  90                  95      
Ala Tyr Glu Ser Pro Cys Gln Leu His Gly Arg Phe Tyr Leu Tyr Thr
            100                 105                 110         
Asp Cys Phe Val Ala Gln Leu Met Val Arg Leu Gly Leu Gln Ala Phe
        115                 120                 125             
Leu Thr His Leu Leu Pro His Val Leu Gln Val Leu Ala Gly Ala Glu
    130                 135                 140                 
Ala Ser Gln Glu Glu Ser Lys Asp Leu Ala Gly Ala Ala Glu Glu Glu
145                 150                 155                 160 
Ser Gly Leu Pro Gly Ala Gly Pro Gly Ser Cys Ala Phe Gly Glu Glu
                165                 170                 175     
Ile Pro Met Asp Gly Glu Pro Pro Ala Ser Ser Gly Leu Gly Leu Pro
            180                 185                 190         
Asp Tyr Thr Ser Gly Val Ser Phe His Asp Gln Ala Asp Leu Pro Glu
        195                 200                 205             
Thr Glu Asp Phe Gln Ala Gly Leu Tyr Val Thr Glu Ser Pro Gln Pro
    210                 215                 220                 
Gln Glu Ala Glu Ala Val Ser Leu Gly Arg Leu Ser Asp Lys Ser Ser
225                 230                 235                 240 
Thr Ser Glu Thr Ser Leu Gly Glu Glu Arg Ala Pro Asp Glu Gly Gly
                245                 250                 255     
Ala Pro Val Asp Lys Ser Ser Leu Arg Ser Gly Asp Ser Ser Gln Asp
            260                 265                 270         
Leu Lys Gln Ser Glu Gly Ser Glu Glu Glu Glu Glu Glu Glu Asp Ser
        275                 280                 285             
Cys Val Val Leu Glu Glu Glu Glu Gly Glu Gln Glu Glu Val Thr Gly
    290                 295                 300                 
Ala Ser Glu Leu Thr Leu Ser Asp Thr Val Leu Ser Met Glu Thr Val
305                 310                 315                 320 
Val Ala Gly Gly Ser Gly Gly Asp Gly Glu Glu Glu Glu Glu Ala Leu
                325                 330                 335     
Pro Glu Gln Ser Glu Gly Lys Glu Gln Lys Ile Leu Leu Asp Thr Ala
            340                 345                 350         
Cys Lys Met Val Arg Trp Leu Ser Ala Lys Leu Gly Pro Thr Val Ala
        355                 360                 365             
Ser Arg His Val Ala Arg Asn Leu Leu Arg Leu Leu Thr Ser Cys Tyr
    370                 375                 380                 
Val Gly Pro Thr Arg Gln Gln Phe Thr Val Ser Ser Gly Glu Ser Pro
385                 390                 395                 400 
Pro Leu Ser Ala Gly Asn Ile Tyr Gln Lys Arg Pro Val Leu Gly Asp
                405                 410                 415     
Ile Val Ser Gly Pro Val Leu Ser Cys Leu Leu His Ile Ala Arg Leu
            420                 425                 430         
Tyr Gly Glu Pro Val Leu Thr Tyr Gln Tyr Leu Pro Tyr Ile Ser Tyr
        435                 440                 445             
Leu Val Ala Pro Gly Ser Ala Ser Gly Pro Ser Arg Leu Asn Ser Arg
    450                 455                 460                 
Lys Glu Ala Gly Leu Leu Ala Ala Val Thr Leu Thr Gln Lys Ile Ile
465                 470                 475                 480 
Val Tyr Leu Ser Asp Thr Thr Leu Met Asp Ile Leu Pro Arg Ile Ser
                485                 490                 495     
His Glu Val Leu Leu Pro Val Leu Ser Phe Leu Thr Ser Leu Val Thr
            500                 505                 510         
Gly Phe Pro Ser Gly Ala Gln Ala Arg Thr Ile Leu Cys Val Lys Thr
        515                 520                 525             
Ile Ser Leu Ile Ala Leu Ile Cys Leu Arg Ile Gly Gln Glu Met Val
    530                 535                 540                 
Gln Gln His Leu Ser Glu Pro Val Ala Thr Phe Phe Gln Val Phe Ser
545                 550                 555                 560 
Gln Leu His Glu Leu Arg Gln Gln Asp Leu Lys Leu Asp Pro Ala Gly
                565                 570                 575     
Arg Gly Glu Gly Gln Leu Pro Gln Val Val Phe Ser Asp Gly Gln Gln
            580                 585                 590         
Arg Pro Val Asp Pro Ala Leu Leu Asp Glu Leu Gln Lys Val Phe Thr
        595                 600                 605             
Leu Glu Met Ala Tyr Thr Ile Tyr Val Pro Phe Ser Cys Leu Leu Gly
    610                 615                 620                 
Asp Ile Ile Arg Lys Ile Ile Pro Asn His Glu Leu Val Gly Glu Leu
625                 630                 635                 640 
Ala Ala Leu Tyr Leu Glu Ser Ile Ser Pro Ser Ser Arg Asn Pro Ala
                645                 650                 655     
Ser Val Glu Pro Thr Met Pro Gly Thr Gly His Glu Trp Asp Pro His
            660                 665                 670         
Gly Gly Gly Cys Pro Gln Asp Asp Gly His Ser Gly Thr Phe Gly Ser
        675                 680                 685             
Val Leu Val Gly Asn Arg Ile Gln Ile Pro Asn Asp Ser Arg Pro Glu
    690                 695                 700                 
Asn Pro Gly Pro Leu Gly Pro Ile Ser Gly Val Gly Gly Gly Gly Leu
705                 710                 715                 720 
Gly Ser Gly Ser Asp Asp Asn Ala Leu Lys Gln Glu Leu Pro Arg Ser
                725                 730                 735     
Val His Gly Leu Ser Gly Asn Trp Leu Ala Tyr Trp Gln Tyr Glu Ile
            740                 745                 750         
Gly Val Ser Gln Gln Asp Ala His Phe His Phe His Gln Ile Arg Leu
        755                 760                 765             
Gln Ser Phe Pro Gly His Ser Gly Ala Val Lys Cys Val Ala Pro Leu
    770                 775                 780                 
Ser Ser Glu Asp Phe Phe Leu Ser Gly Ser Lys Asp Arg Thr Val Arg
785                 790                 795                 800 
Leu Trp Pro Leu Tyr Asn Tyr Gly Asp Gly Thr Ser Glu Thr Ala Pro
                805                 810                 815     
Arg Leu Val Tyr Thr Gln His Arg Lys Ser Val Phe Phe Val Gly Gln
            820                 825                 830         
Leu Glu Ala Pro Gln His Val Val Ser Cys Asp Gly Ala Val His Val
        835                 840                 845             
Trp Asp Pro Phe Thr Gly Lys Thr Leu Arg Thr Val Glu Pro Leu Asp
    850                 855                 860                 
Ser Arg Val Pro Leu Thr Ala Val Ala Val Met Pro Ala Pro His Thr
865                 870                 875                 880 
Ser Ile Thr Met Ala Ser Ser Asp Ser Thr Leu Arg Phe Val Asp Cys
                885                 890                 895     
Arg Lys Pro Gly Leu Gln Val Arg Gly Val Gln Phe Pro Glu His Ser
            900                 905                 910         
Pro Gly Ser Leu Gly Thr Trp Gln Gly Gly Glu Thr Pro Gln Lys Gln
        915                 920                 925             
Lys Ala Arg Met Leu Phe Trp Gly Pro Ser
    930                 935             


<210> 2985
<211> 1079
<212> PRT
<213> Homo sapiens

<400> 2985
Met Leu Trp Pro Arg Asn Leu Thr Ser Trp Asp Asp Ser Ser Ser Val
 1               5                  10                  15      
Ser Ser Gly Ile Ser Asp Thr Ile Asp Asn Leu Ser Thr Asp Asp Ile
            20                  25                  30          
Asn Thr Ser Ser Ser Ile Ser Ser Tyr Ala Asn Thr Pro Ala Ser Ser
        35                  40                  45              
Arg Lys Asn Leu Asp Val Gln Thr Asp Ala Glu Lys His Ser Gln Val
    50                  55                  60                  
Glu Arg Asn Ser Leu Trp Ser Gly Asp Asp Val Lys Lys Ser Asp Gly
65                  70                  75                  80  
Gly Ser Asp Ser Gly Ile Lys Met Glu Pro Gly Ser Lys Trp Arg Arg
                85                  90                  95      
Asn Pro Ser Asp Val Ser Asp Asp Ser Asp Lys Ser Met Ser Gly Lys
            100                 105                 110         
Lys Asn Pro Val Ile Ser Gln Thr Gly Ser Trp Arg Arg Gly Met Thr
        115                 120                 125             
Ala Gln Val Gly Ile Thr Met Pro Arg Thr Lys Ala Ser Ala Pro Ala
    130                 135                 140                 
Gly Ala Leu Lys Thr Pro Gly Thr Gly Lys Thr Asp Asp Ala Lys Val
145                 150                 155                 160 
Ser Glu Lys Gly Arg Leu Ser Pro Lys Ala Ser Gln Val Lys Arg Ser
                165                 170                 175     
Pro Ser Asp Ala Gly Arg Ser Ser Gly Asp Glu Ser Lys Lys Pro Leu
            180                 185                 190         
Pro Ser Ser Ser Arg Thr Pro Thr Ala Asn Ala Asn Ser Phe Gly Phe
        195                 200                 205             
Lys Lys Gln Ser Gly Ser Ala Ala Gly Leu Ala Met Ile Thr Ala Ser
    210                 215                 220                 
Gly Val Thr Val Thr Ser Arg Ser Ala Thr Leu Asp Lys Ile Pro Lys
225                 230                 235                 240 
Ser Ser Ala Leu Val Ser Arg Ser Ala Gly Arg Lys Ser Ser Met Asp
                245                 250                 255     
Gly Ala Gln Asn Gln Asp Asp Gly Tyr Leu Ala Leu Ser Ser Arg Thr
            260                 265                 270         
Asn Leu Gln Tyr Arg Ser Leu Pro Arg Pro Ser Lys Ser Asn Ser Arg
        275                 280                 285             
Asn Gly Ala Gly Asn Arg Ser Ser Thr Ser Ser Ile Asp Ser Asn Ile
    290                 295                 300                 
Ser Ser Lys Ser Ala Gly Leu Pro Val Pro Lys Leu Arg Glu Pro Ser
305                 310                 315                 320 
Lys Thr Ala Leu Gly Ser Ser Leu Pro Gly Leu Val Asn Gln Thr Asp
                325                 330                 335     
Lys Glu Lys Gly Ile Ser Ser Asp Asn Glu Ser Val Ala Ser Cys Asn
            340                 345                 350         
Ser Val Lys Val Asn Pro Ala Ala Gln Pro Val Ser Ser Pro Ala Gln
        355                 360                 365             
Thr Ser Leu Gln Pro Gly Ala Lys Tyr Pro Asp Val Ala Ser Pro Thr
    370                 375                 380                 
Leu Arg Arg Leu Phe Gly Gly Lys Pro Thr Lys Gln Val Pro Ile Ala
385                 390                 395                 400 
Thr Ala Glu Asn Met Lys Asn Ser Val Val Ile Ser Asn Pro His Ala
                405                 410                 415     
Thr Met Thr Gln Gln Gly Asn Leu Asp Ser Pro Ser Gly Ser Gly Val
            420                 425                 430         
Leu Ser Ser Gly Ser Ser Ser Pro Leu Tyr Ser Lys Asn Val Asp Leu
        435                 440                 445             
Asn Gln Ser Pro Leu Ala Ser Ser Pro Ser Ser Ala His Ser Ala Pro
    450                 455                 460                 
Ser Asn Ser Leu Thr Trp Gly Thr Asn Ala Ser Ser Ser Ser Ala Val
465                 470                 475                 480 
Ser Lys Asp Gly Leu Gly Phe Gln Ser Val Ser Ser Leu His Thr Ser
                485                 490                 495     
Cys Glu Ser Ile Asp Ile Ser Leu Ser Ser Gly Gly Val Pro Ser His
            500                 505                 510         
Asn Ser Ser Thr Gly Leu Ile Ala Ser Ser Lys Asp Asp Ser Leu Thr
        515                 520                 525             
Pro Phe Val Arg Thr Asn Ser Val Lys Thr Thr Leu Ser Glu Ser Asp
    530                 535                 540                 
Pro His Leu Asp Arg Asn Thr Leu Pro Lys Lys Gly Leu Arg Tyr Thr
545                 550                 555                 560 
Pro Thr Ser Gln Leu Arg Thr Gln Glu Asp Ala Lys Glu Trp Leu Arg
                565                 570                 575     
Ser His Ser Ala Gly Gly Leu Gln Asp Thr Ala Ala Asn Ser Pro Phe
            580                 585                 590         
Ser Ser Gly Ser Ser Val Thr Ser Pro Ser Gly Thr Arg Phe Asn Phe
        595                 600                 605             
Ser Gln Leu Ala Ser Pro Thr Thr Val Thr Gln Met Ser Leu Ser Asn
    610                 615                 620                 
Pro Thr Met Leu Arg Thr His Ser Leu Ser Asn Ala Asp Gly Gln Tyr
625                 630                 635                 640 
Asp Pro Tyr Thr Asp Ser Arg Phe Arg Asn Ser Ser Met Ser Leu Asp
                645                 650                 655     
Glu Lys Ser Arg Thr Met Ser Arg Ser Gly Ser Phe Arg Asp Gly Phe
            660                 665                 670         
Glu Glu Val His Gly Ser Ser Leu Ser Leu Val Ser Ser Thr Ser Ser
        675                 680                 685             
Val Tyr Ser Thr Pro Glu Glu Lys Cys Gln Ser Glu Ile Arg Lys Leu
    690                 695                 700                 
Arg Arg Glu Leu Asp Ala Ser Gln Glu Lys Val Ser Ala Leu Thr Thr
705                 710                 715                 720 
Gln Leu Thr Ala Asn Ala His Leu Val Ala Ala Phe Glu Gln Ser Leu
                725                 730                 735     
Gly Asn Met Thr Ile Arg Leu Gln Ser Leu Thr Met Thr Ala Glu Gln
            740                 745                 750         
Lys Asp Ser Glu Leu Asn Glu Leu Arg Lys Thr Ile Glu Leu Leu Lys
        755                 760                 765             
Lys Gln Asn Ala Ala Ala Gln Ala Ala Ile Asn Gly Val Ile Asn Thr
    770                 775                 780                 
Pro Glu Leu Asn Cys Lys Gly Asn Gly Thr Ala Gln Ser Ala Asp Leu
785                 790                 795                 800 
Arg Ile Arg Arg Gln His Ser Ser Asp Ser Val Ser Ser Ile Asn Ser
                805                 810                 815     
Ala Thr Ser His Ser Ser Val Gly Ser Asn Ile Glu Ser Asp Ser Lys
            820                 825                 830         
Lys Lys Lys Arg Lys Asn Trp Leu Arg Ser Ser Phe Lys Gln Ala Phe
        835                 840                 845             
Gly Lys Lys Lys Ser Pro Lys Ser Ala Ser Ser His Ser Asp Ile Glu
    850                 855                 860                 
Glu Met Thr Asp Ser Ser Leu Pro Ser Ser Pro Lys Leu Pro His Asn
865                 870                 875                 880 
Gly Ser Thr Gly Ser Thr Pro Leu Leu Arg Asn Ser His Ser Asn Ser
                885                 890                 895     
Leu Ile Ser Glu Cys Met Asp Ser Glu Ala Glu Thr Val Met Gln Leu
            900                 905                 910         
Arg Asn Glu Leu Arg Asp Lys Glu Met Lys Leu Thr Asp Ile Arg Leu
        915                 920                 925             
Glu Ala Leu Ser Ser Ala His Gln Leu Asp Gln Leu Arg Glu Ala Val
    930                 935                 940                 
Asn Arg Met Gln Ser Glu Ile Glu Lys Leu Lys Ala Glu Asn Asp Arg
945                 950                 955                 960 
Leu Lys Ser Glu Ser Gln Gly Ser Gly Cys Ser Arg Ala Pro Ser Gln
                965                 970                 975     
Val Ser Ile Ser Ala Ser Pro Arg Gln Ser Met Gly Leu Ser Gln His
            980                 985                 990         
Ser Leu Asn Leu Thr Glu Ser Thr Ser Leu Asp Met Leu Leu Asp Asp
        995                 1000                1005            
Thr Gly Glu Cys Ser Ala Arg Lys Glu Gly Gly Arg His Val Lys Ile
    1010                1015                1020                
Val Val Ser Phe Gln Glu Glu Met Lys Trp Lys Glu Asp Ser Arg Pro
1025                1030                1035                1040
His Leu Phe Leu Ile Gly Cys Ile Gly Val Ser Gly Lys Thr Lys Trp
                1045                1050                1055    
Asp Val Leu Asp Gly Val Val Arg Arg Leu Phe Lys Glu Tyr Ile Ile
            1060                1065                1070        
His Val Asp Pro Val Ser Gln
        1075                


<210> 2986
<211> 960
<212> PRT
<213> Homo sapiens

<400> 2986
Met Trp Arg Leu Arg Arg Ala Ala Val Ala Cys Glu Val Cys Gln Ser
 1               5                  10                  15      
Leu Val Lys His Ser Ser Gly Ile Lys Gly Ser Leu Pro Leu Gln Lys
            20                  25                  30          
Leu His Leu Val Ser Arg Ser Ile Tyr His Ser His His Pro Thr Leu
        35                  40                  45              
Lys Leu Gln Arg Pro Gln Leu Arg Thr Ser Phe Gln Gln Phe Ser Ser
    50                  55                  60                  
Leu Thr Asn Leu Pro Leu Arg Lys Leu Lys Phe Ser Pro Ile Lys Tyr
65                  70                  75                  80  
Gly Tyr Gln Pro Arg Arg Asn Phe Trp Pro Ala Arg Leu Ala Thr Arg
                85                  90                  95      
Leu Leu Lys Leu Arg Tyr Leu Ile Leu Gly Ser Ala Val Gly Gly Gly
            100                 105                 110         
Tyr Thr Ala Lys Lys Thr Phe Asp Gln Trp Lys Asp Met Ile Pro Asp
        115                 120                 125             
Leu Ser Glu Tyr Lys Trp Ile Val Pro Asp Ile Val Trp Glu Ile Asp
    130                 135                 140                 
Glu Tyr Ile Asp Phe Glu Lys Ile Arg Lys Ala Leu Pro Asn Ser Glu
145                 150                 155                 160 
Asp Leu Val Lys Leu Ala Pro Asp Phe Asp Lys Ile Val Glu Ser Leu
                165                 170                 175     
Ser Leu Leu Lys Asp Phe Phe Thr Ser Gly Ser Pro Glu Glu Thr Ala
            180                 185                 190         
Phe Arg Ala Thr Asp Arg Gly Ser Glu Ser Asp Lys His Phe Arg Lys
        195                 200                 205             
Val Ser Asp Lys Glu Lys Ile Asp Gln Leu Gln Glu Glu Leu Leu His
    210                 215                 220                 
Thr Gln Leu Lys Tyr Gln Arg Ile Leu Glu Arg Leu Glu Lys Glu Asn
225                 230                 235                 240 
Lys Glu Leu Arg Lys Leu Val Leu Gln Lys Asp Asp Lys Gly Ile His
                245                 250                 255     
His Arg Lys Leu Lys Lys Ser Leu Ile Asp Met Tyr Ser Glu Val Leu
            260                 265                 270         
Asp Val Leu Ser Asp Tyr Asp Ala Ser Tyr Asn Thr Gln Asp His Leu
        275                 280                 285             
Pro Arg Val Val Val Val Gly Asp Gln Ser Ala Gly Lys Thr Ser Val
    290                 295                 300                 
Leu Glu Met Ile Ala Gln Ala Arg Ile Phe Pro Arg Gly Ser Gly Glu
305                 310                 315                 320 
Met Met Thr Arg Ser Pro Val Lys Val Thr Leu Ser Glu Gly Pro His
                325                 330                 335     
His Val Ala Leu Phe Lys Asp Ser Ser Arg Glu Phe Asp Leu Thr Lys
            340                 345                 350         
Glu Glu Asp Leu Ala Ala Leu Arg His Glu Ile Glu Leu Arg Met Arg
        355                 360                 365             
Lys Asn Val Lys Glu Gly Cys Thr Val Ser Pro Glu Thr Ile Ser Leu
    370                 375                 380                 
Asn Val Lys Gly Pro Gly Leu Gln Arg Met Val Leu Val Asp Leu Pro
385                 390                 395                 400 
Gly Val Ile Asn Thr Val Thr Ser Gly Met Ala Pro Asp Thr Lys Glu
                405                 410                 415     
Thr Ile Phe Ser Ile Ser Lys Ala Tyr Met Gln Asn Pro Asn Ala Ile
            420                 425                 430         
Ile Leu Cys Ile Gln Asp Gly Ser Val Asp Ala Glu Arg Ser Ile Val
        435                 440                 445             
Thr Asp Leu Val Ser Gln Met Asp Pro His Gly Arg Arg Thr Ile Phe
    450                 455                 460                 
Val Leu Thr Lys Val Asp Leu Ala Glu Lys Asn Val Ala Ser Pro Ser
465                 470                 475                 480 
Arg Ile Gln Gln Ile Ile Glu Gly Lys Leu Phe Pro Met Lys Ala Leu
                485                 490                 495     
Gly Tyr Phe Ala Val Val Thr Gly Lys Gly Asn Ser Ser Glu Ser Ile
            500                 505                 510         
Glu Ala Ile Arg Glu Tyr Glu Glu Glu Phe Phe Gln Asn Ser Lys Leu
        515                 520                 525             
Leu Lys Thr Ser Met Leu Lys Ala His Gln Val Thr Thr Arg Asn Leu
    530                 535                 540                 
Ser Leu Ala Val Ser Asp Cys Phe Trp Lys Met Val Arg Glu Ser Val
545                 550                 555                 560 
Glu Gln Gln Ala Asp Ser Phe Lys Ala Thr Arg Phe Asn Leu Glu Thr
                565                 570                 575     
Glu Trp Lys Asn Asn Tyr Pro Arg Leu Arg Glu Leu Asp Arg Asn Glu
            580                 585                 590         
Leu Phe Glu Lys Ala Lys Asn Glu Ile Leu Asp Glu Val Ile Ser Leu
        595                 600                 605             
Ser Gln Val Thr Pro Lys His Trp Glu Glu Ile Leu Gln Gln Ser Leu
    610                 615                 620                 
Trp Glu Arg Val Ser Thr His Val Ile Glu Asn Ile Tyr Leu Pro Ala
625                 630                 635                 640 
Ala Gln Thr Met Asn Ser Gly Thr Phe Asn Thr Thr Val Asp Ile Lys
                645                 650                 655     
Leu Lys Gln Trp Thr Asp Lys Gln Leu Pro Asn Lys Ala Val Glu Val
            660                 665                 670         
Ala Trp Glu Thr Leu Gln Glu Glu Phe Ser Arg Phe Met Thr Glu Pro
        675                 680                 685             
Lys Gly Lys Glu His Asp Asp Ile Phe Asp Lys Leu Lys Glu Ala Val
    690                 695                 700                 
Lys Glu Glu Ser Ile Lys Arg His Lys Trp Asn Asp Phe Ala Glu Asp
705                 710                 715                 720 
Ser Leu Arg Val Ile Gln His Asn Ala Leu Glu Asp Arg Ser Ile Ser
                725                 730                 735     
Asp Lys Gln Gln Trp Asp Ala Ala Ile Tyr Phe Met Glu Glu Ala Leu
            740                 745                 750         
Gln Ala Arg Leu Lys Asp Thr Glu Asn Ala Ile Glu Asn Met Val Gly
        755                 760                 765             
Pro Asp Trp Lys Lys Arg Trp Leu Tyr Trp Lys Asn Arg Thr Gln Glu
    770                 775                 780                 
Gln Cys Val His Asn Glu Thr Lys Asn Glu Leu Glu Lys Met Leu Lys
785                 790                 795                 800 
Cys Asn Glu Glu His Pro Ala Tyr Leu Ala Ser Asp Glu Ile Thr Thr
                805                 810                 815     
Val Arg Lys Asn Leu Glu Ser Arg Gly Val Glu Val Asp Pro Ser Leu
            820                 825                 830         
Ile Lys Asp Thr Trp His Gln Val Tyr Arg Arg His Phe Leu Lys Thr
        835                 840                 845             
Ala Leu Asn His Cys Asn Leu Cys Arg Arg Gly Phe Tyr Tyr Tyr Gln
    850                 855                 860                 
Arg His Phe Val Asp Ser Glu Leu Glu Cys Asn Asp Val Val Leu Phe
865                 870                 875                 880 
Trp Arg Ile Gln Arg Met Leu Ala Ile Thr Ala Asn Thr Leu Arg Gln
                885                 890                 895     
Gln Leu Thr Asn Thr Glu Val Arg Arg Leu Glu Lys Asn Val Lys Glu
            900                 905                 910         
Val Leu Glu Asp Phe Ala Glu Asp Gly Glu Lys Lys Ile Lys Leu Leu
        915                 920                 925             
Thr Gly Lys Arg Val Gln Leu Ala Glu Asp Leu Lys Lys Val Arg Glu
    930                 935                 940                 
Ile Gln Glu Lys Leu Asp Ala Phe Ile Glu Ala Leu His Gln Glu Lys
945                 950                 955                 960 


<210> 2987
<211> 997
<212> PRT
<213> Homo sapiens

<400> 2987
Met Trp Arg Leu Arg Arg Ala Ala Val Ala Cys Glu Val Cys Gln Ser
 1               5                  10                  15      
Leu Val Lys His Ser Ser Gly Ile Lys Gly Ser Leu Pro Leu Gln Lys
            20                  25                  30          
Leu His Leu Val Ser Arg Ser Ile Tyr His Ser His His Pro Thr Leu
        35                  40                  45              
Lys Leu Gln Arg Pro Gln Leu Arg Thr Ser Phe Gln Gln Phe Ser Ser
    50                  55                  60                  
Leu Thr Asn Leu Pro Leu Arg Lys Leu Lys Phe Ser Pro Ile Lys Tyr
65                  70                  75                  80  
Gly Tyr Gln Pro Arg Arg Asn Phe Trp Pro Ala Arg Leu Ala Thr Arg
                85                  90                  95      
Leu Leu Lys Leu Arg Tyr Leu Ile Leu Gly Ser Ala Val Gly Gly Gly
            100                 105                 110         
Tyr Thr Ala Lys Lys Thr Phe Asp Gln Trp Lys Asp Met Ile Pro Asp
        115                 120                 125             
Leu Ser Glu Tyr Lys Trp Ile Val Pro Asp Ile Val Trp Glu Ile Asp
    130                 135                 140                 
Glu Tyr Ile Asp Phe Glu Lys Ile Arg Lys Ala Leu Pro Asn Ser Glu
145                 150                 155                 160 
Asp Leu Val Lys Leu Ala Pro Asp Phe Asp Lys Ile Val Glu Ser Leu
                165                 170                 175     
Ser Leu Leu Lys Asp Phe Phe Thr Ser Gly Ser Pro Glu Glu Thr Ala
            180                 185                 190         
Phe Arg Ala Thr Asp Arg Gly Ser Glu Ser Asp Lys His Phe Arg Lys
        195                 200                 205             
Gly Leu Leu Gly Glu Leu Ile Leu Leu Gln Gln Gln Ile Gln Glu His
    210                 215                 220                 
Glu Glu Glu Ala Arg Arg Ala Ala Gly Gln Tyr Ser Thr Ser Tyr Ala
225                 230                 235                 240 
Gln Gln Lys Arg Lys Val Ser Asp Lys Glu Lys Ile Asp Gln Leu Gln
                245                 250                 255     
Glu Glu Leu Leu His Thr Gln Leu Lys Tyr Gln Arg Ile Leu Glu Arg
            260                 265                 270         
Leu Glu Lys Glu Asn Lys Glu Leu Arg Lys Leu Val Leu Gln Lys Asp
        275                 280                 285             
Asp Lys Gly Ile His His Arg Lys Leu Lys Lys Ser Leu Ile Asp Met
    290                 295                 300                 
Tyr Ser Glu Val Leu Asp Val Leu Ser Asp Tyr Asp Ala Ser Tyr Asn
305                 310                 315                 320 
Thr Gln Asp His Leu Pro Arg Val Val Val Val Gly Asp Gln Ser Ala
                325                 330                 335     
Gly Lys Thr Ser Val Leu Glu Met Ile Ala Gln Ala Arg Ile Phe Pro
            340                 345                 350         
Arg Gly Ser Gly Glu Met Met Thr Arg Ser Pro Val Lys Val Thr Leu
        355                 360                 365             
Ser Glu Gly Pro His His Val Ala Leu Phe Lys Asp Ser Ser Arg Glu
    370                 375                 380                 
Phe Asp Leu Thr Lys Glu Glu Asp Leu Ala Ala Leu Arg His Glu Ile
385                 390                 395                 400 
Glu Leu Arg Met Arg Lys Asn Val Lys Glu Gly Cys Thr Val Ser Pro
                405                 410                 415     
Glu Thr Ile Ser Leu Asn Val Lys Gly Pro Gly Leu Gln Arg Met Val
            420                 425                 430         
Leu Val Asp Leu Pro Gly Val Ile Asn Thr Val Thr Ser Gly Met Ala
        435                 440                 445             
Pro Asp Thr Lys Glu Thr Ile Phe Ser Ile Ser Lys Ala Tyr Met Gln
    450                 455                 460                 
Asn Pro Asn Ala Ile Ile Leu Cys Ile Gln Asp Gly Ser Val Asp Ala
465                 470                 475                 480 
Glu Arg Ser Ile Val Thr Asp Leu Val Ser Gln Met Asp Pro His Gly
                485                 490                 495     
Arg Arg Thr Ile Phe Val Leu Thr Lys Val Asp Leu Ala Glu Lys Asn
            500                 505                 510         
Val Ala Ser Pro Ser Arg Ile Gln Gln Ile Ile Glu Gly Lys Leu Phe
        515                 520                 525             
Pro Met Lys Ala Leu Gly Tyr Phe Ala Val Val Thr Gly Lys Gly Asn
    530                 535                 540                 
Ser Ser Glu Ser Ile Glu Ala Ile Arg Glu Tyr Glu Glu Glu Phe Phe
545                 550                 555                 560 
Gln Asn Ser Lys Leu Leu Lys Thr Ser Met Leu Lys Ala His Gln Val
                565                 570                 575     
Thr Thr Arg Asn Leu Ser Leu Ala Val Ser Asp Cys Phe Trp Lys Met
            580                 585                 590         
Val Arg Glu Ser Val Glu Gln Gln Ala Asp Ser Phe Lys Ala Thr Arg
        595                 600                 605             
Phe Asn Leu Glu Thr Glu Trp Lys Asn Asn Tyr Pro Arg Leu Arg Glu
    610                 615                 620                 
Leu Asp Arg Asn Glu Leu Phe Glu Lys Ala Lys Asn Glu Ile Leu Asp
625                 630                 635                 640 
Glu Val Ile Ser Leu Ser Gln Val Thr Pro Lys His Trp Glu Glu Ile
                645                 650                 655     
Leu Gln Gln Ser Leu Trp Glu Arg Val Ser Thr His Val Ile Glu Asn
            660                 665                 670         
Ile Tyr Leu Pro Ala Ala Gln Thr Met Asn Ser Gly Thr Phe Asn Thr
        675                 680                 685             
Thr Val Asp Ile Lys Leu Lys Gln Trp Thr Asp Lys Gln Leu Pro Asn
    690                 695                 700                 
Lys Ala Val Glu Val Ala Trp Glu Thr Leu Gln Glu Glu Phe Ser Arg
705                 710                 715                 720 
Phe Met Thr Glu Pro Lys Gly Lys Glu His Asp Asp Ile Phe Asp Lys
                725                 730                 735     
Leu Lys Glu Ala Val Lys Glu Glu Ser Ile Lys Arg His Lys Trp Asn
            740                 745                 750         
Asp Phe Ala Glu Asp Ser Leu Arg Val Ile Gln His Asn Ala Leu Glu
        755                 760                 765             
Asp Arg Ser Ile Ser Asp Lys Gln Gln Trp Asp Ala Ala Ile Tyr Phe
    770                 775                 780                 
Met Glu Glu Ala Leu Gln Ala Arg Leu Lys Asp Thr Glu Asn Ala Ile
785                 790                 795                 800 
Glu Asn Met Val Gly Pro Asp Trp Lys Lys Arg Trp Leu Tyr Trp Lys
                805                 810                 815     
Asn Arg Thr Gln Glu Gln Cys Val His Asn Glu Thr Lys Asn Glu Leu
            820                 825                 830         
Glu Lys Met Leu Lys Cys Asn Glu Glu His Pro Ala Tyr Leu Ala Ser
        835                 840                 845             
Asp Glu Ile Thr Thr Val Arg Lys Asn Leu Glu Ser Arg Gly Val Glu
    850                 855                 860                 
Val Asp Pro Ser Leu Ile Lys Asp Thr Trp His Gln Val Tyr Arg Arg
865                 870                 875                 880 
His Phe Leu Lys Thr Ala Leu Asn His Cys Asn Leu Cys Arg Arg Gly
                885                 890                 895     
Phe Tyr Tyr Tyr Gln Arg His Phe Val Asp Ser Glu Leu Glu Cys Asn
            900                 905                 910         
Asp Val Val Leu Phe Trp Arg Ile Gln Arg Met Leu Ala Ile Thr Ala
        915                 920                 925             
Asn Thr Leu Arg Gln Gln Leu Thr Asn Thr Glu Val Arg Arg Leu Glu
    930                 935                 940                 
Lys Asn Val Lys Glu Val Leu Glu Asp Phe Ala Glu Asp Gly Glu Lys
945                 950                 955                 960 
Lys Ile Lys Leu Leu Thr Gly Lys Arg Val Gln Leu Ala Glu Asp Leu
                965                 970                 975     
Lys Lys Val Arg Glu Ile Gln Glu Lys Leu Asp Ala Phe Ile Glu Ala
            980                 985                 990         
Leu His Gln Glu Lys
        995         


<210> 2988
<211> 735
<212> PRT
<213> Homo sapiens

<400> 2988
Val Arg Ile Leu Val Leu Cys Gly Thr Arg Arg Gly Trp Thr Glu Thr
 1               5                  10                  15      
Val Pro Thr Leu Glu Cys Gly Ala Gly Gly Pro Arg Gly His Ser Leu
            20                  25                  30          
Cys Arg Leu Gly Gly Pro Ser Gly Thr Glu Ser Val Thr Leu Ser Gly
        35                  40                  45              
Thr Ala Pro Gly Trp Glu Pro Pro Asp Asp Pro Asp Thr Gly Ser Glu
    50                  55                  60                  
Cys Ser His Pro Glu Val Ser Pro Ser Pro Arg Phe Val Ala Ala Lys
65                  70                  75                  80  
Thr Gln Thr Asn Gln Ser Gly Lys Lys Ala Pro Ala Ser Val Val Arg
                85                  90                  95      
Cys Ala Thr Leu Leu His Arg Thr Pro Pro Ala Thr Gln Thr Gln Thr
            100                 105                 110         
Phe Arg Thr Pro Asn Ser Gly Ser Pro Ala Ser Lys Ala Thr Ala Ala
        115                 120                 125             
Glu Ser Ala Phe Ser Arg Arg Val Glu Gly Lys Ala Gln Asn His Phe
    130                 135                 140                 
Glu Glu Thr Asn Ser Ser Ser Gln Asn Ser Ser Glu Thr Ala Ser Pro
145                 150                 155                 160 
Leu Ile Ser Asn Pro Phe Pro Leu Leu Gln Lys Pro Tyr Thr Cys Gly
                165                 170                 175     
Ala Cys Gly Ile Gln Phe Gln Phe Tyr Asn Asn Leu Leu Glu His Met
            180                 185                 190         
Gln Ser His Ala Ala Asp Asn Glu Asn Asn Ile Ala Ser Asn Gln Ser
        195                 200                 205             
Arg Ser Pro Pro Ala Val Val Glu Glu Lys Trp Lys Pro Gln Ala Gln
    210                 215                 220                 
Arg Asn Ser Ala Asn Asn Thr Thr Thr Ser Gly Leu Thr Pro Asn Ser
225                 230                 235                 240 
Met Ile Pro Glu Lys Glu Arg Gln Asn Ile Ala Glu Arg Leu Leu Arg
                245                 250                 255     
Val Met Cys Ala Asp Leu Gly Ala Leu Ser Val Val Ser Gly Lys Glu
            260                 265                 270         
Phe Leu Lys Leu Ala Gln Thr Leu Val Asp Ser Gly Ala Arg Tyr Gly
        275                 280                 285             
Ala Phe Ser Val Thr Glu Ile Leu Gly Asn Phe Asn Thr Leu Ala Leu
    290                 295                 300                 
Lys His Leu Pro Arg Met Tyr Asn Gln Val Lys Val Lys Val Thr Cys
305                 310                 315                 320 
Ala Leu Gly Ser Asn Ala Cys Leu Gly Ile Gly Val Thr Cys His Ser
                325                 330                 335     
Gln Ser Val Gly Pro Asp Ser Cys Tyr Ile Leu Thr Ala Tyr Gln Ala
            340                 345                 350         
Glu Gly Asn His Ile Lys Ser Tyr Val Leu Gly Val Lys Gly Ala Asp
        355                 360                 365             
Ile Arg Asp Ser Gly Asp Leu Val His His Trp Val Gln Asn Val Leu
    370                 375                 380                 
Ser Glu Phe Val Met Ser Glu Ile Arg Thr Val Tyr Val Thr Asp Cys
385                 390                 395                 400 
Arg Val Ser Thr Ser Ala Phe Ser Lys Ala Gly Met Cys Leu Arg Cys
                405                 410                 415     
Ser Ala Cys Ala Leu Asn Ser Val Val Gln Ser Val Leu Ser Lys Arg
            420                 425                 430         
Thr Leu Gln Ala Arg Ser Met His Glu Val Ile Glu Leu Leu Asn Val
        435                 440                 445             
Cys Glu Asp Leu Ala Gly Ser Thr Gly Leu Ala Lys Glu Thr Phe Gly
    450                 455                 460                 
Ser Leu Glu Glu Thr Ser Pro Pro Pro Cys Trp Asn Ser Val Thr Asp
465                 470                 475                 480 
Ser Leu Leu Leu Val His Glu Arg Tyr Glu Gln Ile Cys Glu Phe Tyr
                485                 490                 495     
Ser Arg Ala Lys Lys Met Asn Leu Ile Gln Ser Leu Asn Lys His Leu
            500                 505                 510         
Leu Ser Asn Leu Ala Ala Ile Leu Thr Pro Val Lys Gln Ala Val Ile
        515                 520                 525             
Glu Leu Ser Asn Glu Ser Gln Pro Thr Leu Gln Leu Val Leu Pro Thr
    530                 535                 540                 
Tyr Val Arg Leu Glu Lys Leu Phe Thr Ala Lys Ala Asn Asp Ala Gly
545                 550                 555                 560 
Thr Val Ser Lys Leu Cys His Leu Phe Leu Glu Ala Leu Lys Glu Asn
                565                 570                 575     
Phe Lys Val His Pro Ala His Lys Val Ala Met Ile Leu Asp Pro Gln
            580                 585                 590         
Gln Lys Leu Arg Pro Val Pro Pro Tyr Gln His Glu Glu Ile Ile Gly
        595                 600                 605             
Lys Val Cys Glu Leu Ile Asn Glu Val Lys Glu Ser Trp Ala Glu Glu
    610                 615                 620                 
Ala Asp Phe Glu Pro Ala Ala Lys Lys Pro Arg Ser Ala Ala Val Glu
625                 630                 635                 640 
Asn Pro Ala Ala Gln Glu Asp Asp Arg Leu Gly Lys Asn Glu Val Tyr
                645                 650                 655     
Asp Tyr Leu Gln Glu Pro Leu Phe Gln Ala Thr Pro Asp Leu Phe Gln
            660                 665                 670         
Tyr Trp Ser Cys Val Thr Gln Lys His Thr Lys Leu Ala Lys Leu Ala
        675                 680                 685             
Phe Trp Leu Leu Ala Val Pro Ala Val Gly Ala Arg Ser Gly Cys Val
    690                 695                 700                 
Asn Met Cys Glu Gln Ala Leu Leu Ile Lys Arg Arg Arg Leu Leu Ser
705                 710                 715                 720 
Pro Glu Asp Met Asn Lys Leu Met Phe Leu Lys Ser Asn Met Leu
                725                 730                 735 


<210> 2989
<211> 830
<212> PRT
<213> Homo sapiens

<400> 2989
Gln Ala Val Arg Gly Gly Gln Ala Arg Ala Arg Arg Ala Leu Gly Pro
 1               5                  10                  15      
Leu Leu Pro Thr Ala Met Glu Asp Glu Gln Pro Asp Ser Leu Glu Gly
            20                  25                  30          
Trp Val Pro Val Arg Glu Gly Leu Phe Ala Glu Pro Glu Arg His Arg
        35                  40                  45              
Leu Arg Phe Leu Val Ala Trp Asn Gly Ala Glu Gly Lys Phe Ala Val
    50                  55                  60                  
Thr Cys His Asp Arg Thr Ala Gln Gln Arg Arg Leu Arg Glu Gly Ala
65                  70                  75                  80  
Arg Leu Gly Pro Glu Pro Glu Pro Lys Pro Glu Ala Ala Val Ser Pro
                85                  90                  95      
Ser Ser Trp Ala Gly Leu Leu Ser Ala Ala Gly Leu Arg Gly Ala His
            100                 105                 110         
Arg Gln Leu Ala Ala Leu Trp Pro Pro Leu Glu Arg Cys Phe Pro Arg
        115                 120                 125             
Leu Pro Pro Glu Leu Asp Val Gly Gly Gly Gly Ala Trp Gly Leu Gly
    130                 135                 140                 
Leu Gly Leu Trp Ala Leu Leu Trp Pro Thr Arg Ala Gly Pro Gly Glu
145                 150                 155                 160 
Ala Ala Leu Gln Glu Leu Cys Gly Gln Leu Glu Arg Tyr Leu Gly Ala
                165                 170                 175     
Ala Ala Asp Gly Cys Gly Gly Ala Thr Val Arg Asp Ala Leu Phe Pro
            180                 185                 190         
Ala Glu Gly Gly Ala Ala Asp Cys Glu Ser Pro Arg Glu Phe Arg Glu
        195                 200                 205             
Arg Ala Leu Arg Ala Arg Trp Val Glu Ala Asp Ala Arg Leu Arg Gln
    210                 215                 220                 
Val Ile Gln Gly His Gly Lys Ala Asn Thr Met Val Ala Leu Met Asn
225                 230                 235                 240 
Val Tyr Gln Glu Glu Asp Glu Ala Tyr Gln Glu Leu Val Thr Val Ala
                245                 250                 255     
Thr Met Phe Phe Gln Tyr Leu Leu Gln Pro Phe Arg Ala Met Arg Glu
            260                 265                 270         
Val Ala Thr Leu Cys Lys Leu Asp Ile Leu Lys Ser Leu Asp Glu Asp
        275                 280                 285             
Asp Leu Gly Pro Arg Arg Val Val Ala Leu Glu Lys Glu Ala Glu Glu
    290                 295                 300                 
Trp Thr Arg Arg Ala Glu Glu Ala Val Val Ser Ile Gln Asp Ile Thr
305                 310                 315                 320 
Val Asn Tyr Phe Lys Glu Thr Val Lys Ala Leu Ala Gly Met Gln Lys
                325                 330                 335     
Glu Met Glu Gln Asp Ala Lys Arg Phe Gly Gln Ala Ala Trp Ala Thr
            340                 345                 350         
Ala Ile Pro Arg Leu Glu Lys Leu Gln Leu Met Leu Ala Arg Glu Thr
        355                 360                 365             
Leu Gln Leu Met Arg Ala Lys Glu Leu Cys Leu Asn His Lys Arg Ala
    370                 375                 380                 
Glu Ile Gln Gly Lys Met Glu Asp Leu Pro Glu Gln Glu Lys Asn Thr
385                 390                 395                 400 
Asn Val Val Asp Glu Leu Glu Ile Gln Phe Tyr Glu Ile Gln Leu Glu
                405                 410                 415     
Leu Tyr Glu Val Lys Phe Glu Ile Leu Lys Asn Glu Glu Ile Leu Leu
            420                 425                 430         
Thr Thr Gln Leu Asp Ser Leu Lys Arg Leu Ile Lys Glu Lys Gln Asp
        435                 440                 445             
Glu Val Val Tyr Tyr Asp Pro Cys Glu Asn Pro Glu Glu Leu Lys Val
    450                 455                 460                 
Ile Asp Cys Val Val Gly Leu Gln Asp Asp Lys Asn Leu Glu Val Lys
465                 470                 475                 480 
Glu Leu Arg Arg Gln Cys Gln Gln Leu Glu Ser Lys Arg Gly Arg Ile
                485                 490                 495     
Cys Ala Lys Arg Ala Ser Leu Arg Ser Arg Lys Asp Gln Cys Lys Glu
            500                 505                 510         
Asn His Arg Phe Arg Leu Gln Gln Ala Glu Glu Ser Ile Arg Tyr Ser
        515                 520                 525             
Arg Gln His His Ser Ile Gln Met Lys Arg Asp Lys Ile Lys Glu Glu
    530                 535                 540                 
Glu Gln Lys Lys Lys Glu Trp Ile Asn Gln Glu Arg Gln Lys Thr Leu
545                 550                 555                 560 
Gln Arg Leu Arg Ser Phe Lys Asp Lys Arg Leu Ala Gln Ser Val Arg
                565                 570                 575     
Asn Thr Ser Gly Ser Glu Pro Val Ala Pro Asn Leu Pro Ser Asp Leu
            580                 585                 590         
Ser Gln Gln Met Cys Leu Pro Ala Ser His Ala Val Ser Val Ile His
        595                 600                 605             
Pro Ser Ser Arg Lys Thr Arg Gly Val Pro Leu Ser Glu Ala Gly Asn
    610                 615                 620                 
Val Lys Ser Pro Lys Cys Gln Asn Cys His Gly Asn Ile Pro Val Gln
625                 630                 635                 640 
Val Phe Val Pro Val Gly Asp Gln Thr His Ser Lys Ser Ser Glu Glu
                645                 650                 655     
Leu Ser Leu Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro
            660                 665                 670         
Pro Pro Pro Pro Pro Pro Pro Leu Arg Ala Leu Ser Ser Ser Ser Gln
        675                 680                 685             
Ala Ala Thr His Gln Asn Leu Gly Phe Arg Ala Pro Val Lys Asp Asp
    690                 695                 700                 
Gln Pro Arg Pro Leu Val Cys Glu Ser Pro Ala Glu Arg Pro Arg Asp
705                 710                 715                 720 
Ser Leu Glu Ser Phe Ser Cys Pro Gly Ser Met Asp Glu Val Leu Ala
                725                 730                 735     
Ser Leu Arg His Gly Arg Ala Pro Leu Arg Lys Val Glu Val Pro Ala
            740                 745                 750         
Val Arg Pro Pro His Ala Ser Ile Asn Glu His Ile Leu Ala Ala Ile
        755                 760                 765             
Arg Gln Gly Val Lys Leu Lys Lys Val His Pro Asp Leu Gly Pro Asn
    770                 775                 780                 
Pro Ser Ser Lys Pro Thr Ser Asn Arg Arg Thr Ser Asp Leu Glu Arg
785                 790                 795                 800 
Ser Ile Lys Ala Ala Leu Gln Arg Ile Lys Arg Val Ser Ala Asp Ser
                805                 810                 815     
Glu Glu Asp Ser Asp Glu Gln Asp Pro Gly Gln Trp Asp Gly
            820                 825                 830 


<210> 2990
<211> 1273
<212> PRT
<213> Homo sapiens

<400> 2990
Met Pro Cys Phe Tyr Leu Arg Ser Cys Gly Ser Leu Leu Pro Glu Leu
 1               5                  10                  15      
Lys Leu Glu Glu Arg Thr Glu Phe Ala His Arg Ile Trp Asp Thr Leu
            20                  25                  30          
Gln Lys Leu Gly Ala Val Tyr Asp Val Ser His Tyr Asn Ala Leu Leu
        35                  40                  45              
Lys Val Tyr Leu Gln Asn Glu Tyr Lys Phe Ser Pro Thr Asp Phe Leu
    50                  55                  60                  
Ala Lys Met Glu Glu Ala Asn Ile Gln Pro Asn Arg Val Thr Tyr Gln
65                  70                  75                  80  
Arg Leu Ile Ala Ser Tyr Cys Asn Val Gly Asp Ile Glu Gly Ala Ser
                85                  90                  95      
Lys Ile Leu Gly Phe Met Lys Thr Lys Asp Leu Pro Val Thr Glu Ala
            100                 105                 110         
Val Phe Ser Ala Leu Val Thr Gly His Ala Arg Ala Gly Asp Met Glu
        115                 120                 125             
Asn Ala Glu Asn Ile Leu Thr Val Met Arg Asp Ala Gly Ile Glu Pro
    130                 135                 140                 
Gly Pro Asp Thr Tyr Leu Ala Leu Leu Asn Ala Tyr Ala Glu Lys Gly
145                 150                 155                 160 
Asp Ile Asp His Val Lys Gln Thr Leu Glu Lys Val Glu Lys Phe Glu
                165                 170                 175     
Leu His Leu Met Asp Arg Asp Leu Leu Gln Ile Ile Phe Ser Phe Ser
            180                 185                 190         
Lys Ala Gly Tyr Leu Ser Met Ser Gln Lys Phe Trp Lys Lys Phe Thr
        195                 200                 205             
Cys Glu Arg Arg Tyr Ile Pro Asp Ala Met Asn Leu Ile Leu Leu Leu
    210                 215                 220                 
Val Thr Glu Lys Leu Glu Asp Val Ala Leu Gln Ile Leu Leu Ala Cys
225                 230                 235                 240 
Pro Val Ser Lys Glu Asp Gly Pro Ser Val Phe Gly Ser Phe Phe Leu
                245                 250                 255     
Gln His Cys Val Thr Met Asn Thr Pro Val Glu Lys Leu Thr Asp Tyr
            260                 265                 270         
Cys Lys Lys Leu Lys Glu Val Gln Met His Ser Phe Pro Leu Gln Phe
        275                 280                 285             
Thr Leu His Cys Ala Leu Leu Ala Asn Lys Thr Asp Leu Ala Lys Ala
    290                 295                 300                 
Leu Met Lys Ala Val Lys Glu Glu Gly Phe Pro Ile Arg Pro His Tyr
305                 310                 315                 320 
Phe Trp Pro Leu Leu Val Gly Arg Arg Lys Glu Lys Asn Val Gln Gly
                325                 330                 335     
Ile Ile Glu Ile Leu Lys Gly Met Gln Glu Leu Gly Val His Pro Asp
            340                 345                 350         
Gln Glu Thr Tyr Thr Asp Tyr Val Ile Pro Cys Phe Asp Ser Val Asn
        355                 360                 365             
Ser Ala Arg Ala Ile Leu Gln Glu Asn Gly Cys Leu Ser Asp Ser Asp
    370                 375                 380                 
Met Phe Ser Gln Ala Gly Leu Arg Ser Glu Ala Ala Asn Gly Asn Leu
385                 390                 395                 400 
Asp Phe Val Leu Ser Phe Leu Lys Ser Asn Thr Leu Pro Ile Ser Leu
                405                 410                 415     
Gln Ser Ile Arg Ser Ser Leu Leu Leu Gly Phe Arg Arg Ser Met Asn
            420                 425                 430         
Ile Asn Val Trp Ser Glu Ile Thr Glu Leu Leu Tyr Lys Asp Gly Arg
        435                 440                 445             
Tyr Cys Gln Glu Pro Arg Gly Pro Thr Glu Ala Val Gly Asn Phe Leu
    450                 455                 460                 
Tyr Asn Leu Ile Asp Ser Met Ser Asp Ser Glu Val Gln Ala Lys Glu
465                 470                 475                 480 
Glu His Leu Arg Gln Tyr Phe His Gln Leu Glu Lys Met Asn Val Lys
                485                 490                 495     
Ile Pro Glu Asn Ile Tyr Arg Gly Ile Arg Asn Leu Leu Glu Ser Tyr
            500                 505                 510         
His Val Pro Glu Leu Ile Lys Asp Ala His Leu Leu Val Glu Arg Lys
        515                 520                 525             
Asn Leu Asp Phe Gln Lys Thr Val Gln Leu Thr Ser Ser Glu Leu Glu
    530                 535                 540                 
Ser Thr Leu Glu Thr Leu Lys Ala Glu Asn Gln Pro Ile Arg Asp Val
545                 550                 555                 560 
Leu Lys Gln Leu Ile Leu Val Leu Cys Ser Glu Glu Asn Met Gln Lys
                565                 570                 575     
Ala Leu Glu Leu Lys Ala Lys Tyr Glu Ser Asp Met Val Thr Gly Gly
            580                 585                 590         
Tyr Ala Ala Leu Ile Asn Leu Cys Cys Arg His Asp Lys Val Glu Asp
        595                 600                 605             
Ala Leu Asn Leu Lys Glu Glu Phe Asp Arg Leu Asp Ser Ser Ala Val
    610                 615                 620                 
Leu Asp Thr Gly Asn Tyr Leu Gly Leu Val Arg Val Leu Ala Lys His
625                 630                 635                 640 
Gly Lys Leu Gln Asp Ala Ile Lys Ile Leu Lys Glu Met Lys Glu Lys
                645                 650                 655     
Asp Val Leu Ile Lys Asp Thr Thr Ala Leu Ser Phe Phe His Met Leu
            660                 665                 670         
Asn Gly Ala Ala Leu Arg Gly Glu Ile Glu Thr Val Lys Gln Leu His
        675                 680                 685             
Glu Ala Ile Val Thr Leu Gly Leu Ala Glu Pro Ser Thr Asn Ile Ser
    690                 695                 700                 
Phe Pro Leu Val Thr Val His Leu Glu Lys Gly Asp Leu Ser Thr Ala
705                 710                 715                 720 
Leu Glu Val Ala Ile Asp Cys Tyr Glu Lys Tyr Lys Val Leu Pro Arg
                725                 730                 735     
Ile His Asp Val Leu Cys Lys Leu Val Glu Lys Gly Glu Thr Asp Leu
            740                 745                 750         
Ile Gln Lys Ala Met Asp Phe Val Ser Gln Glu Gln Gly Glu Met Val
        755                 760                 765             
Met Leu Tyr Asp Leu Phe Phe Ala Phe Leu Gln Thr Gly Asn Tyr Lys
    770                 775                 780                 
Glu Ala Lys Lys Ile Ile Glu Thr Pro Gly Ile Arg Ala Arg Ser Ala
785                 790                 795                 800 
Arg Leu Gln Trp Phe Cys Asp Arg Cys Val Ala Asn Asn Gln Val Glu
                805                 810                 815     
Thr Leu Glu Lys Leu Val Glu Leu Thr Gln Lys Leu Phe Glu Cys Asp
            820                 825                 830         
Arg Asp Gln Met Tyr Tyr Asn Leu Leu Lys Leu Tyr Lys Ile Asn Gly
        835                 840                 845             
Asp Trp Gln Arg Ala Asp Ala Val Trp Asn Lys Ile Gln Glu Glu Asn
    850                 855                 860                 
Val Ile Pro Arg Glu Lys Thr Leu Arg Leu Leu Ala Glu Ile Leu Arg
865                 870                 875                 880 
Glu Gly Asn Gln Glu Val Pro Phe Asp Val Pro Glu Leu Trp Tyr Glu
                885                 890                 895     
Asp Glu Lys His Ser Leu Asn Ser Ser Ser Ala Ser Thr Thr Glu Pro
            900                 905                 910         
Asp Phe Gln Lys Asp Ile Leu Ile Ala Cys Arg Leu Asn Gln Lys Lys
        915                 920                 925             
Gly Ala Tyr Asp Ile Phe Leu Asn Ala Lys Glu Gln Asn Ile Val Phe
    930                 935                 940                 
Asn Ala Glu Thr Tyr Ser Asn Leu Ile Lys Leu Leu Met Ser Glu Asp
945                 950                 955                 960 
Tyr Phe Thr Gln Ala Met Glu Val Lys Ala Phe Ala Glu Thr His Ile
                965                 970                 975     
Lys Gly Phe Thr Leu Asn Asp Ala Ala Asn Ser Arg Leu Ile Ile Thr
            980                 985                 990         
Gln Val Arg Arg Asp Tyr Leu Lys Glu Ala Val Thr Thr Leu Lys Thr
        995                 1000                1005            
Val Leu Asp Gln Gln Gln Thr Pro Ser Arg Leu Ala Val Thr Arg Val
    1010                1015                1020                
Ile Gln Ala Leu Ala Met Lys Gly Asp Val Glu Asn Ile Glu Val Val
1025                1030                1035                1040
Gln Lys Met Leu Asn Gly Leu Glu Asp Ser Ile Gly Leu Ser Lys Met
                1045                1050                1055    
Val Phe Ile Asn Asn Ile Ala Leu Ala Gln Ile Lys Asn Asn Asn Ile
            1060                1065                1070        
Asp Ala Ala Ile Glu Asn Ile Glu Asn Met Leu Thr Ser Glu Asn Lys
        1075                1080                1085            
Val Ile Glu Pro Gln Tyr Phe Gly Leu Ala Tyr Leu Phe Arg Lys Val
    1090                1095                1100                
Ile Glu Glu Gln Leu Glu Pro Ala Val Glu Lys Ile Ser Ile Met Ala
1105                1110                1115                1120
Glu Arg Leu Ala Asn Gln Phe Ala Ile Tyr Lys Pro Val Thr Asp Phe
                1125                1130                1135    
Phe Leu Gln Leu Val Asp Ala Gly Lys Val Asp Asp Ala Arg Ala Leu
            1140                1145                1150        
Leu Gln Arg Cys Gly Ala Ile Ala Glu Gln Thr Pro Ile Leu Leu Leu
        1155                1160                1165            
Phe Leu Leu Arg Asn Ser Arg Lys Gln Gly Lys Ala Ser Thr Val Lys
    1170                1175                1180                
Ser Val Leu Glu Leu Ile Pro Glu Leu Asn Glu Lys Glu Glu Ala Tyr
1185                1190                1195                1200
Asn Ser Leu Met Lys Ser Tyr Val Ser Glu Lys Asp Val Thr Ser Ala
                1205                1210                1215    
Lys Ala Leu Tyr Glu His Leu Thr Ala Lys Asn Thr Lys Leu Asp Asp
            1220                1225                1230        
Leu Phe Leu Lys Arg Tyr Ala Ser Leu Leu Lys Tyr Ala Gly Glu Pro
        1235                1240                1245            
Val Pro Phe Ile Glu Pro Pro Glu Ser Phe Glu Phe Tyr Ala Gln Gln
    1250                1255                1260                
Leu Arg Lys Leu Arg Glu Asn Ser Ser
1265                1270            


<210> 2991
<211> 4624
<212> PRT
<213> Homo sapiens

<400> 2991
Met Phe Arg Ile Gly Arg Arg Gln Leu Trp Lys His Ser Val Thr Arg
 1               5                  10                  15      
Val Leu Thr Gln Arg Leu Lys Gly Glu Lys Glu Ala Lys Arg Ala Leu
            20                  25                  30          
Leu Asp Ala Arg His Asn Tyr Leu Phe Ala Ile Val Ala Ser Cys Leu
        35                  40                  45              
Asp Leu Asn Lys Thr Glu Val Glu Asp Ala Ile Leu Glu Gly Asn Gln
    50                  55                  60                  
Ile Glu Arg Ile Asp Gln Leu Phe Ala Val Gly Gly Leu Arg His Leu
65                  70                  75                  80  
Met Phe Tyr Tyr Gln Asp Val Glu Glu Ala Glu Thr Gly Gln Leu Gly
                85                  90                  95      
Ser Leu Gly Gly Val Asn Leu Val Ser Gly Lys Ile Lys Lys Pro Lys
            100                 105                 110         
Val Phe Val Thr Glu Gly Asn Asp Val Ala Leu Thr Gly Val Cys Val
        115                 120                 125             
Phe Phe Ile Arg Thr Asp Pro Ser Lys Ala Ile Thr Pro Asp Asn Ile
    130                 135                 140                 
His Gln Glu Val Ser Phe Asn Met Leu Asp Ala Ala Asp Gly Gly Leu
145                 150                 155                 160 
Leu Asn Ser Val Arg Arg Leu Leu Ser Asp Ile Phe Ile Pro Ala Leu
                165                 170                 175     
Arg Ala Thr Ser His Gly Trp Gly Glu Leu Glu Gly Leu Gln Asp Ala
            180                 185                 190         
Ala Asn Ile Arg Gln Glu Phe Leu Ser Ser Leu Glu Gly Phe Val Asn
        195                 200                 205             
Val Leu Ser Gly Ala Gln Glu Ser Leu Lys Glu Lys Val Asn Leu Arg
    210                 215                 220                 
Lys Cys Asp Ile Leu Glu Leu Lys Thr Leu Lys Glu Pro Thr Asp Tyr
225                 230                 235                 240 
Leu Thr Leu Ala Asn Asn Pro Glu Thr Leu Gly Lys Ile Glu Asp Cys
                245                 250                 255     
Met Lys Val Trp Ile Lys Gln Thr Glu Gln Val Leu Ala Glu Asn Asn
            260                 265                 270         
Gln Leu Leu Lys Glu Ala Asp Asp Val Gly Pro Arg Ala Glu Leu Glu
        275                 280                 285             
His Trp Lys Lys Arg Leu Ser Lys Phe Asn Tyr Leu Leu Glu Gln Leu
    290                 295                 300                 
Lys Ser Pro Asp Val Lys Ala Val Leu Ala Val Leu Ala Ala Ala Lys
305                 310                 315                 320 
Ser Lys Leu Leu Lys Thr Trp Arg Glu Met Asp Ile Arg Ile Thr Asp
                325                 330                 335     
Ala Thr Asn Glu Ala Lys Asp Asn Val Lys Tyr Leu Tyr Thr Leu Glu
            340                 345                 350         
Lys Cys Cys Asp Pro Leu Tyr Ser Ser Asp Pro Leu Ser Met Met Asp
        355                 360                 365             
Ala Ile Pro Thr Leu Ile Asn Ala Ile Lys Met Ile Tyr Ser Ile Ser
    370                 375                 380                 
His Tyr Tyr Asn Thr Ser Glu Lys Ile Thr Ser Leu Phe Val Lys Val
385                 390                 395                 400 
Thr Asn Gln Ile Ile Ser Ala Cys Lys Ala Tyr Ile Thr Asn Asn Gly
                405                 410                 415     
Thr Ala Ser Ile Trp Asn Gln Pro Gln Asp Val Val Glu Glu Lys Ile
            420                 425                 430         
Leu Ser Ala Ile Lys Leu Lys Gln Glu Tyr Gln Leu Cys Phe His Lys
        435                 440                 445             
Thr Lys Gln Lys Leu Lys Gln Asn Pro Asn Ala Lys Gln Phe Asp Phe
    450                 455                 460                 
Ser Glu Met Tyr Ile Phe Gly Lys Phe Glu Thr Phe His Arg Arg Leu
465                 470                 475                 480 
Ala Lys Ile Ile Asp Ile Phe Thr Thr Leu Lys Thr Tyr Ser Val Leu
                485                 490                 495     
Gln Asp Ser Thr Ile Glu Gly Leu Glu Asp Met Ala Thr Lys Tyr Gln
            500                 505                 510         
Gly Ile Val Ala Thr Ile Lys Lys Lys Glu Tyr Asn Phe Leu Asp Gln
        515                 520                 525             
Arg Lys Met Asp Phe Asp Gln Asp Tyr Glu Glu Phe Cys Lys Gln Thr
    530                 535                 540                 
Asn Asp Leu His Asn Glu Leu Arg Lys Phe Met Asp Val Thr Phe Ala
545                 550                 555                 560 
Lys Ile Gln Asn Thr Asn Gln Ala Leu Arg Met Leu Lys Lys Phe Glu
                565                 570                 575     
Arg Leu Asn Ile Pro Asn Leu Gly Ile Asp Asp Lys Tyr Gln Leu Ile
            580                 585                 590         
Leu Glu Asn Tyr Gly Ala Asp Ile Asp Met Ile Ser Lys Leu Tyr Thr
        595                 600                 605             
Lys Gln Lys Tyr Asp Pro Pro Leu Ala Arg Asn Gln Pro Pro Ile Ala
    610                 615                 620                 
Gly Lys Ile Leu Trp Ala Arg Gln Leu Phe His Arg Ile Gln Gln Pro
625                 630                 635                 640 
Met Gln Leu Phe Gln Gln His Pro Ala Val Leu Ser Thr Ala Glu Ala
                645                 650                 655     
Lys Pro Ile Ile Arg Ser Tyr Asn Arg Met Ala Lys Val Leu Leu Glu
            660                 665                 670         
Phe Glu Val Leu Phe His Arg Ala Trp Leu Arg Gln Ile Glu Glu Ile
        675                 680                 685             
His Val Gly Leu Glu Ala Ser Leu Leu Val Lys Ala Pro Gly Thr Gly
    690                 695                 700                 
Glu Leu Phe Val Asn Phe Asp Pro Gln Ile Leu Ile Leu Phe Arg Glu
705                 710                 715                 720 
Thr Glu Cys Met Ala Gln Met Gly Leu Glu Val Ser Pro Leu Ala Thr
                725                 730                 735     
Ser Leu Phe Gln Lys Arg Asp Arg Tyr Lys Arg Asn Phe Ser Asn Met
            740                 745                 750         
Lys Met Met Leu Ala Glu Tyr Gln Arg Val Lys Ser Lys Ile Pro Ala
        755                 760                 765             
Ala Ile Glu Gln Leu Ile Val Pro His Leu Ala Lys Val Asp Glu Ala
    770                 775                 780                 
Leu Gln Pro Gly Leu Ala Ala Leu Thr Trp Thr Ser Leu Asn Ile Glu
785                 790                 795                 800 
Ala Tyr Leu Glu Asn Thr Phe Ala Lys Ile Lys Asp Leu Glu Leu Leu
                805                 810                 815     
Leu Asp Arg Val Asn Asp Leu Ile Glu Phe Arg Ile Asp Ala Ile Leu
            820                 825                 830         
Glu Glu Met Ser Ser Thr Pro Leu Cys Gln Leu Pro Gln Glu Glu Pro
        835                 840                 845             
Leu Thr Cys Glu Glu Phe Leu Gln Met Thr Lys Asp Leu Cys Val Asn
    850                 855                 860                 
Gly Ala Gln Ile Leu His Phe Lys Ser Ser Leu Val Glu Glu Ala Val
865                 870                 875                 880 
Asn Glu Leu Val Asn Met Leu Leu Asp Val Glu Val Leu Ser Glu Glu
                885                 890                 895     
Glu Ser Glu Lys Ile Ser Asn Glu Asn Ser Val Asn Tyr Lys Asn Glu
            900                 905                 910         
Ser Ser Ala Lys Arg Glu Glu Gly Asn Phe Asp Thr Leu Thr Ser Ser
        915                 920                 925             
Ile Asn Ala Arg Ala Asn Ala Leu Leu Leu Thr Thr Val Thr Arg Lys
    930                 935                 940                 
Lys Lys Glu Thr Glu Met Leu Gly Glu Glu Ala Arg Glu Leu Leu Ser
945                 950                 955                 960 
His Phe Asn His Gln Asn Met Asp Ala Leu Leu Lys Val Thr Arg Asn
                965                 970                 975     
Thr Leu Glu Ala Ile Arg Lys Arg Ile His Ser Ser His Thr Ile Asn
            980                 985                 990         
Phe Arg Asp Ser Asn Ser Ala Ser Asn Met Lys Gln Asn Ser Leu Pro
        995                 1000                1005            
Ile Phe Arg Ala Ser Val Thr Leu Ala Ile Pro Asn Ile Val Met Ala
    1010                1015                1020                
Pro Ala Leu Glu Asp Val Gln Gln Thr Leu Asn Lys Ala Val Glu Cys
1025                1030                1035                1040
Ile Ile Ser Val Pro Lys Gly Val Arg Gln Trp Ser Ser Glu Leu Leu
                1045                1050                1055    
Ser Lys Lys Lys Ile Gln Glu Arg Lys Met Ala Ala Leu Gln Ser Asn
            1060                1065                1070        
Glu Asp Ser Asp Ser Asp Val Glu Met Gly Glu Asn Glu Leu Gln Asp
        1075                1080                1085            
Thr Leu Glu Ile Ala Ser Val Asn Leu Pro Ile Pro Val Gln Thr Lys
    1090                1095                1100                
Asn Tyr Tyr Lys Asn Val Ser Glu Asn Lys Glu Ile Val Lys Leu Val
1105                1110                1115                1120
Ser Val Leu Ser Thr Ile Ile Asn Ser Thr Lys Lys Glu Val Ile Thr
                1125                1130                1135    
Ser Met Asp Cys Phe Lys Arg Tyr Asn His Ile Trp Gln Lys Gly Lys
            1140                1145                1150        
Glu Glu Ala Ile Lys Thr Phe Ile Thr Gln Ser Pro Leu Leu Ser Glu
        1155                1160                1165            
Phe Glu Ser Gln Ile Leu Tyr Phe Gln Asn Leu Glu Gln Glu Ile Asn
    1170                1175                1180                
Ala Glu Pro Glu Tyr Val Cys Val Gly Ser Ile Ala Leu Tyr Thr Ala
1185                1190                1195                1200
Asp Leu Lys Phe Ala Leu Thr Ala Glu Thr Lys Ala Trp Met Val Val
                1205                1210                1215    
Ile Gly Arg His Cys Asn Lys Lys Tyr Arg Ser Glu Met Glu Asn Ile
            1220                1225                1230        
Phe Met Leu Ile Glu Glu Phe Asn Lys Lys Leu Asn Arg Pro Ile Lys
        1235                1240                1245            
Asp Leu Asp Asp Ile Arg Ile Ala Met Ala Ala Leu Lys Glu Ile Arg
    1250                1255                1260                
Glu Glu Gln Ile Ser Ile Asp Phe Gln Val Gly Pro Ile Glu Glu Ser
1265                1270                1275                1280
Tyr Ala Leu Leu Asn Arg Tyr Gly Leu Leu Ile Ala Arg Glu Glu Ile
                1285                1290                1295    
Asp Lys Val Asp Thr Leu His Tyr Ala Trp Glu Lys Leu Leu Ala Arg
            1300                1305                1310        
Ala Gly Glu Val Gln Asn Lys Leu Val Ser Leu Gln Pro Ser Phe Lys
        1315                1320                1325            
Lys Glu Leu Ile Ser Ala Val Glu Val Phe Leu Gln Asp Cys His Gln
    1330                1335                1340                
Phe Tyr Leu Asp Tyr Asp Leu Asn Gly Pro Met Ala Ser Gly Leu Lys
1345                1350                1355                1360
Pro Gln Glu Ala Ser Asp Arg Leu Ile Met Phe Gln Asn Gln Phe Asp
                1365                1370                1375    
Asn Ile Tyr Arg Lys Tyr Ile Thr Tyr Thr Gly Gly Glu Glu Leu Phe
            1380                1385                1390        
Gly Leu Pro Ala Thr Gln Tyr Pro Gln Leu Leu Glu Ile Lys Lys Gln
        1395                1400                1405            
Leu Asn Leu Leu Gln Lys Ile Tyr Thr Leu Tyr Asn Ser Val Ile Glu
    1410                1415                1420                
Thr Val Asn Ser Tyr Tyr Asp Ile Leu Trp Ser Glu Val Asn Ile Glu
1425                1430                1435                1440
Lys Ile Asn Asn Glu Leu Leu Glu Phe Gln Asn Arg Cys Arg Lys Leu
                1445                1450                1455    
Pro Arg Ala Leu Lys Asp Trp Gln Ala Phe Leu Asp Leu Lys Lys Ile
            1460                1465                1470        
Ile Asp Asp Phe Ser Glu Cys Cys Pro Leu Leu Glu Tyr Met Ala Ser
        1475                1480                1485            
Lys Ala Met Met Glu Arg His Trp Glu Arg Ile Thr Thr Leu Thr Gly
    1490                1495                1500                
His Ser Leu Asp Val Gly Asn Glu Ser Phe Lys Leu Arg Asn Ile Met
1505                1510                1515                1520
Glu Ala Pro Leu Leu Lys Tyr Lys Glu Glu Ile Glu Asp Ile Cys Ile
                1525                1530                1535    
Ser Ala Val Lys Glu Arg Asp Ile Glu Gln Lys Leu Lys Gln Val Ile
            1540                1545                1550        
Asn Glu Trp Asp Asn Lys Thr Phe Thr Phe Gly Ser Phe Lys Thr Arg
        1555                1560                1565            
Gly Glu Leu Leu Leu Arg Gly Asp Ser Thr Ser Glu Ile Ile Ala Asn
    1570                1575                1580                
Met Glu Asp Ser Leu Met Leu Leu Gly Ser Leu Leu Ser Asn Arg Tyr
1585                1590                1595                1600
Asn Met Pro Phe Lys Ala Gln Ile Gln Lys Trp Val Gln Tyr Leu Ser
                1605                1610                1615    
Asn Ser Thr Asp Ile Ile Glu Ser Trp Met Thr Val Gln Asn Leu Trp
            1620                1625                1630        
Ile Tyr Leu Glu Ala Val Phe Val Gly Gly Asp Ile Ala Lys Gln Leu
        1635                1640                1645            
Pro Lys Glu Ala Lys Arg Phe Ser Asn Ile Asp Lys Ser Trp Val Lys
    1650                1655                1660                
Ile Met Thr Arg Ala His Glu Val Pro Ser Val Val Gln Cys Cys Val
1665                1670                1675                1680
Gly Asp Glu Thr Leu Gly Gln Leu Leu Pro His Leu Leu Asp Gln Leu
                1685                1690                1695    
Glu Ile Cys Gln Lys Ser Leu Thr Gly Tyr Leu Glu Lys Lys Arg Leu
            1700                1705                1710        
Cys Phe Pro Arg Phe Phe Phe Val Ser Asp Pro Ala Leu Leu Glu Ile
        1715                1720                1725            
Leu Gly Gln Ala Ser Asp Ser His Thr Ile Gln Ala His Leu Leu Asn
    1730                1735                1740                
Val Phe Asp Asn Ile Lys Ser Val Lys Phe His Glu Lys Ile Tyr Asp
1745                1750                1755                1760
Arg Ile Leu Ser Ile Ser Ser Gln Glu Gly Glu Thr Ile Glu Leu Asp
                1765                1770                1775    
Lys Pro Val Met Ala Glu Gly Asn Val Glu Val Trp Leu Asn Ser Leu
            1780                1785                1790        
Leu Glu Glu Ser Gln Ser Ser Leu His Leu Val Ile Arg Gln Ala Ala
        1795                1800                1805            
Ala Asn Ile Gln Glu Thr Gly Phe Gln Leu Thr Glu Phe Leu Ser Ser
    1810                1815                1820                
Phe Pro Ala Gln Val Gly Leu Leu Gly Ile Gln Met Ile Trp Thr Arg
1825                1830                1835                1840
Asp Ser Glu Glu Ala Leu Arg Asn Ala Lys Phe Asp Lys Lys Ile Met
                1845                1850                1855    
Gln Lys Thr Asn Gln Ala Phe Leu Glu Leu Leu Asn Thr Leu Ile Asp
            1860                1865                1870        
Val Thr Thr Arg Asp Leu Ser Ser Thr Glu Arg Val Lys Tyr Glu Thr
        1875                1880                1885            
Leu Ile Thr Ile His Val His Gln Arg Asp Ile Phe Asp Asp Leu Cys
    1890                1895                1900                
His Met His Ile Lys Ser Pro Met Asp Phe Glu Trp Leu Lys Gln Cys
1905                1910                1915                1920
Arg Phe Tyr Phe Asn Glu Asp Ser Asp Lys Met Met Ile His Ile Thr
                1925                1930                1935    
Asp Val Ala Phe Ile Tyr Gln Asn Glu Phe Leu Gly Cys Thr Asp Arg
            1940                1945                1950        
Leu Val Ile Thr Pro Leu Thr Asp Arg Cys Tyr Ile Thr Leu Ala Gln
        1955                1960                1965            
Ala Leu Gly Met Ser Met Gly Gly Ala Pro Ala Gly Pro Ala Gly Thr
    1970                1975                1980                
Gly Lys Thr Glu Thr Thr Lys Asp Met Gly Arg Cys Leu Gly Lys Tyr
1985                1990                1995                2000
Val Val Val Phe Asn Cys Ser Asp Gln Met Asp Phe Arg Gly Leu Gly
                2005                2010                2015    
Arg Ile Phe Lys Gly Leu Ala Gln Ser Gly Ser Trp Gly Cys Phe Asp
            2020                2025                2030        
Glu Phe Asn Arg Ile Asp Leu Pro Val Leu Ser Val Ala Ala Gln Gln
        2035                2040                2045            
Ile Ser Ile Ile Leu Thr Cys Lys Lys Glu His Lys Lys Ser Phe Ile
    2050                2055                2060                
Phe Thr Asp Gly Asp Asn Val Thr Met Asn Pro Glu Phe Gly Leu Phe
2065                2070                2075                2080
Leu Thr Met Asn Pro Gly Tyr Ala Gly Arg Gln Glu Leu Pro Glu Asn
                2085                2090                2095    
Leu Lys Ile Asn Phe Arg Ser Val Ala Met Met Val Pro Asp Arg Gln
            2100                2105                2110        
Ile Ile Ile Arg Val Lys Leu Ala Ser Cys Gly Phe Ile Asp Asn Val
        2115                2120                2125            
Val Leu Ala Arg Lys Phe Phe Thr Leu Tyr Lys Leu Cys Glu Glu Gln
    2130                2135                2140                
Leu Ser Lys Gln Val His Tyr Asp Phe Gly Leu Arg Asn Ile Leu Ser
2145                2150                2155                2160
Val Leu Arg Thr Leu Gly Ala Ala Lys Arg Ala Asn Pro Met Asp Thr
                2165                2170                2175    
Glu Ser Thr Ile Val Met Arg Val Leu Arg Asp Met Asn Leu Ser Lys
            2180                2185                2190        
Leu Ile Asp Glu Asp Glu Pro Leu Phe Leu Ser Leu Ile Glu Asp Leu
        2195                2200                2205            
Phe Pro Asn Ile Leu Leu Asp Lys Ala Gly Tyr Pro Glu Leu Glu Ala
    2210                2215                2220                
Ala Ile Ser Arg Gln Val Glu Glu Ala Gly Leu Ile Asn His Pro Pro
2225                2230                2235                2240
Trp Lys Leu Lys Val Ile Gln Leu Phe Glu Thr Gln Arg Val Arg His
                2245                2250                2255    
Gly Met Met Thr Leu Gly Pro Ser Gly Ala Gly Lys Thr Thr Cys Ile
            2260                2265                2270        
His Thr Leu Met Arg Ala Met Thr Asp Cys Gly Lys Pro His Arg Glu
        2275                2280                2285            
Met Arg Met Asn Pro Lys Ala Ile Thr Ala Pro Gln Met Phe Gly Arg
    2290                2295                2300                
Leu Asp Val Ala Thr Asn Asp Trp Thr Asp Gly Ile Phe Ser Thr Leu
2305                2310                2315                2320
Trp Arg Lys Thr Leu Arg Ala Lys Lys Gly Glu His Ile Trp Ile Ile
                2325                2330                2335    
Leu Asp Gly Pro Val Asp Ala Ile Trp Ile Glu Asn Leu Asn Ser Val
            2340                2345                2350        
Leu Asp Asp Asn Lys Thr Leu Thr Leu Ala Asn Gly Asp Arg Ile Pro
        2355                2360                2365            
Met Ala Pro Asn Cys Lys Ile Ile Phe Glu Pro His Asn Ile Asp Asn
    2370                2375                2380                
Ala Ser Pro Ala Thr Val Ser Arg Asn Gly Met Val Phe Met Ser Ser
2385                2390                2395                2400
Ser Ile Leu Asp Trp Ser Pro Ile Leu Glu Gly Phe Leu Lys Lys Arg
                2405                2410                2415    
Ser Pro Gln Glu Ala Glu Ile Leu Arg Gln Leu Tyr Thr Glu Ser Phe
            2420                2425                2430        
Pro Asp Leu Tyr Arg Phe Cys Ile Gln Asn Leu Glu Tyr Lys Met Glu
        2435                2440                2445            
Val Leu Glu Ala Phe Val Ile Thr Gln Ser Ile Asn Met Leu Gln Gly
    2450                2455                2460                
Leu Ile Pro Leu Lys Glu Gln Gly Gly Glu Val Ser Gln Ala His Leu
2465                2470                2475                2480
Gly Arg Leu Phe Val Phe Ala Leu Leu Trp Ser Ala Gly Ala Ala Leu
                2485                2490                2495    
Glu Leu Asp Gly Arg Arg Arg Leu Glu Leu Trp Leu Arg Ser Arg Pro
            2500                2505                2510        
Thr Gly Thr Leu Glu Leu Pro Pro Pro Ala Gly Pro Gly Asp Thr Ala
        2515                2520                2525            
Phe Asp Tyr Tyr Val Ala Pro Asp Gly Thr Trp Thr His Trp Asn Thr
    2530                2535                2540                
Arg Thr Gln Glu Tyr Leu Tyr Pro Ser Asp Thr Thr Pro Glu Tyr Gly
2545                2550                2555                2560
Ser Ile Leu Val Pro Asn Val Asp Asn Val Arg Thr Asp Phe Leu Ile
                2565                2570                2575    
Gln Thr Ile Ala Lys Gln Gly Lys Ala Val Leu Leu Ile Gly Glu Gln
            2580                2585                2590        
Gly Thr Ala Lys Thr Val Ile Ile Lys Gly Phe Met Ser Lys Tyr Asp
        2595                2600                2605            
Pro Glu Cys His Met Ile Lys Ser Leu Asn Phe Ser Ser Ala Thr Thr
    2610                2615                2620                
Pro Leu Met Phe Gln Arg Thr Ile Glu Ser Tyr Val Asp Lys Arg Met
2625                2630                2635                2640
Gly Thr Thr Tyr Gly Pro Pro Ala Gly Lys Lys Met Thr Val Phe Ile
                2645                2650                2655    
Asp Asp Val Asn Met Pro Ile Ile Asn Glu Trp Gly Asp Gln Val Thr
            2660                2665                2670        
Asn Glu Ile Val Arg Gln Leu Met Glu Gln Asn Gly Phe Tyr Asn Leu
        2675                2680                2685            
Glu Lys Pro Gly Glu Phe Thr Ser Ile Val Asp Ile Gln Phe Leu Ala
    2690                2695                2700                
Ala Met Ile His Pro Gly Gly Gly Arg Asn Asp Ile Pro Gln Arg Leu
2705                2710                2715                2720
Lys Arg Gln Phe Ser Ile Phe Asn Cys Thr Leu Pro Ser Glu Ala Ser
                2725                2730                2735    
Val Asp Lys Ile Phe Gly Val Ile Gly Val Gly His Tyr Cys Thr Gln
            2740                2745                2750        
Arg Gly Phe Ser Glu Glu Val Arg Asp Ser Val Thr Lys Leu Val Pro
        2755                2760                2765            
Leu Thr Arg Arg Leu Trp Gln Met Thr Lys Ile Lys Met Leu Pro Thr
    2770                2775                2780                
Pro Ala Lys Phe His Tyr Val Phe Asn Leu Arg Asp Leu Ser Arg Val
2785                2790                2795                2800
Trp Gln Gly Met Leu Asn Thr Thr Ser Glu Val Ile Lys Glu Pro Asn
                2805                2810                2815    
Asp Leu Leu Lys Leu Trp Lys His Glu Cys Lys Arg Val Ile Ala Asp
            2820                2825                2830        
Arg Phe Thr Val Ser Ser Asp Val Thr Trp Phe Asp Lys Ala Leu Val
        2835                2840                2845            
Ser Leu Val Glu Glu Glu Phe Gly Glu Glu Lys Lys Leu Leu Val Asp
    2850                2855                2860                
Cys Gly Ile Asp Thr Tyr Phe Val Asp Phe Leu Arg Asp Ala Pro Glu
2865                2870                2875                2880
Ala Ala Gly Glu Thr Ser Glu Glu Ala Asp Ala Glu Thr Pro Lys Ile
                2885                2890                2895    
Tyr Glu Pro Ile Glu Ser Phe Ser His Leu Lys Glu Arg Leu Asn Met
            2900                2905                2910        
Phe Leu Gln Leu Tyr Asn Glu Ser Ile Arg Gly Ala Gly Met Asp Met
        2915                2920                2925            
Val Phe Phe Ala Asp Ala Met Val His Leu Val Lys Ile Ser Arg Val
    2930                2935                2940                
Ile Arg Thr Pro Gln Gly Asn Ala Leu Leu Val Gly Val Gly Gly Ser
2945                2950                2955                2960
Gly Lys Gln Ser Leu Thr Arg Leu Ala Ser Phe Ile Ala Gly Tyr Val
                2965                2970                2975    
Ser Phe Gln Ile Thr Leu Thr Arg Ser Tyr Asn Thr Ser Asn Leu Met
            2980                2985                2990        
Glu Asp Leu Lys Val Leu Tyr Arg Thr Ala Gly Gln Gln Gly Lys Gly
        2995                3000                3005            
Ile Thr Phe Ile Phe Thr Asp Asn Glu Ile Lys Asp Glu Ser Phe Leu
    3010                3015                3020                
Glu Tyr Met Asn Asn Val Leu Ser Ser Gly Glu Val Ser Asn Leu Phe
3025                3030                3035                3040
Ala Arg Asp Glu Ile Asp Glu Ile Asn Ser Asp Leu Ala Ser Val Met
                3045                3050                3055    
Lys Lys Glu Phe Pro Arg Cys Leu Pro Thr Asn Glu Asn Leu His Asp
            3060                3065                3070        
Tyr Phe Met Ser Arg Val Arg Gln Asn Leu His Ile Val Leu Cys Phe
        3075                3080                3085            
Ser Pro Val Gly Glu Lys Phe Arg Asn Arg Ala Leu Lys Phe Pro Ala
    3090                3095                3100                
Leu Ile Ser Gly Cys Thr Ile Asp Trp Phe Ser Arg Trp Pro Lys Asp
3105                3110                3115                3120
Ala Leu Val Ala Val Ser Glu His Phe Leu Thr Ser Tyr Asp Ile Asp
                3125                3130                3135    
Cys Ser Leu Glu Ile Lys Lys Glu Val Val Gln Cys Met Gly Ser Phe
            3140                3145                3150        
Gln Asp Gly Val Ala Glu Lys Cys Val Asp Tyr Phe Gln Arg Phe Arg
        3155                3160                3165            
Arg Ser Thr His Val Thr Pro Lys Ser Tyr Leu Ser Phe Ile Gln Gly
    3170                3175                3180                
Tyr Lys Phe Ile Tyr Gly Glu Lys His Val Glu Val Arg Thr Leu Ala
3185                3190                3195                3200
Asn Arg Met Asn Thr Gly Leu Glu Lys Leu Lys Glu Ala Ser Glu Ser
                3205                3210                3215    
Val Ala Ala Leu Ser Lys Glu Leu Glu Ala Lys Glu Lys Glu Leu Gln
            3220                3225                3230        
Val Ala Asn Asp Lys Ala Asp Met Val Leu Lys Glu Val Thr Met Lys
        3235                3240                3245            
Ala Gln Ala Ala Glu Lys Val Lys Ala Glu Val Gln Lys Val Lys Asp
    3250                3255                3260                
Arg Ala Gln Ala Ile Val Asp Ser Ile Ser Lys Asp Lys Ala Ile Ala
3265                3270                3275                3280
Glu Glu Lys Leu Glu Ala Ala Lys Pro Ala Leu Glu Glu Ala Glu Ala
                3285                3290                3295    
Ala Leu Gln Thr Ile Arg Pro Ser Asp Ile Ala Thr Val Arg Thr Leu
            3300                3305                3310        
Gly Arg Pro Pro His Leu Ile Met Arg Ile Met Asp Cys Val Leu Leu
        3315                3320                3325            
Leu Phe Gln Arg Lys Val Ser Ala Val Lys Ile Asp Leu Glu Lys Ser
    3330                3335                3340                
Cys Thr Met Pro Ser Trp Gln Glu Ser Leu Lys Leu Met Thr Ala Gly
3345                3350                3355                3360
Asn Phe Leu Gln Asn Leu Gln Gln Phe Pro Lys Asp Thr Ile Asn Glu
                3365                3370                3375    
Glu Val Ile Glu Phe Leu Ser Pro Tyr Phe Glu Met Pro Asp Tyr Asn
            3380                3385                3390        
Ile Glu Thr Ala Lys Arg Val Cys Gly Asn Val Ala Gly Leu Cys Ser
        3395                3400                3405            
Trp Thr Lys Ala Met Ala Ser Phe Phe Ser Ile Asn Lys Glu Val Leu
    3410                3415                3420                
Pro Leu Lys Ala Asn Leu Val Val Gln Glu Asn Arg His Leu Leu Ala
3425                3430                3435                3440
Met Gln Asp Leu Gln Lys Ala Gln Ala Glu Leu Asp Asp Lys Gln Ala
                3445                3450                3455    
Glu Leu Asp Val Val Gln Ala Glu Tyr Glu Gln Ala Met Thr Glu Lys
            3460                3465                3470        
Gln Thr Leu Leu Glu Asp Ala Glu Arg Cys Arg His Lys Met Gln Thr
        3475                3480                3485            
Ala Ser Thr Leu Ile Ser Gly Leu Ala Gly Glu Lys Glu Arg Trp Thr
    3490                3495                3500                
Glu Gln Ser Gln Glu Phe Ala Ala Gln Thr Lys Arg Leu Val Gly Asp
3505                3510                3515                3520
Val Leu Leu Ala Thr Ala Phe Leu Ser Tyr Ser Gly Pro Phe Asn Gln
                3525                3530                3535    
Glu Phe Arg Asp Leu Leu Leu Asn Asp Trp Arg Lys Glu Met Lys Ala
            3540                3545                3550        
Arg Lys Ile Pro Phe Gly Lys Asn Leu Asn Leu Ser Glu Met Leu Ile
        3555                3560                3565            
Asp Ala Pro Thr Ile Ser Glu Trp Asn Leu Gln Gly Leu Pro Asn Asp
    3570                3575                3580                
Asp Leu Ser Ile Gln Asn Gly Ile Ile Val Thr Lys Ala Ser Arg Tyr
3585                3590                3595                3600
Pro Leu Leu Ile Asp Pro Gln Thr Gln Gly Lys Ile Trp Ile Lys Asn
                3605                3610                3615    
Lys Glu Ser Arg Asn Glu Leu Gln Ile Thr Ser Leu Asn His Lys Tyr
            3620                3625                3630        
Phe Arg Asn His Leu Glu Asp Ser Leu Ser Leu Gly Arg Pro Leu Leu
        3635                3640                3645            
Ile Glu Asp Val Gly Glu Glu Leu Asp Pro Ala Leu Asp Asn Val Leu
    3650                3655                3660                
Glu Arg Asn Phe Ile Lys Thr Gly Ser Thr Phe Lys Val Lys Val Gly
3665                3670                3675                3680
Asp Lys Glu Val Asp Val Leu Asp Gly Phe Arg Leu Tyr Ile Thr Thr
                3685                3690                3695    
Lys Leu Pro Asn Pro Ala Tyr Thr Pro Glu Ile Ser Ala Arg Thr Ser
            3700                3705                3710        
Ile Ile Asp Phe Thr Val Thr Met Lys Gly Leu Glu Asp Gln Leu Leu
        3715                3720                3725            
Gly Arg Val Ile Leu Thr Glu Lys Gln Glu Leu Glu Lys Glu Arg Thr
    3730                3735                3740                
His Leu Met Glu Asp Val Thr Ala Asn Lys Arg Arg Met Lys Glu Leu
3745                3750                3755                3760
Glu Asp Asn Leu Leu Tyr Arg Leu Thr Ser Thr Gln Gly Ser Leu Val
                3765                3770                3775    
Glu Asp Glu Ser Leu Ile Val Val Leu Ser Asn Thr Lys Arg Thr Ala
            3780                3785                3790        
Glu Glu Val Thr Gln Lys Leu Glu Ile Ser Ala Glu Thr Glu Val Gln
        3795                3800                3805            
Ile Asn Ser Ala Arg Glu Glu Tyr Arg Pro Val Ala Thr Arg Gly Ser
    3810                3815                3820                
Ile Leu Tyr Phe Leu Ile Thr Glu Met Arg Leu Val Asn Glu Met Tyr
3825                3830                3835                3840
Gln Thr Ser Leu Arg Gln Phe Leu Gly Leu Phe Asp Leu Ser Leu Ala
                3845                3850                3855    
Arg Ser Val Lys Ser Pro Ile Thr Ser Lys Arg Ile Ala Asn Ile Ile
            3860                3865                3870        
Glu His Met Thr Tyr Glu Val Tyr Lys Tyr Ala Ala Arg Gly Leu Tyr
        3875                3880                3885            
Glu Glu His Lys Phe Leu Phe Thr Leu Leu Leu Thr Leu Lys Ile Asp
    3890                3895                3900                
Ile Gln Arg Asn Arg Val Lys His Glu Glu Phe Leu Thr Leu Ile Lys
3905                3910                3915                3920
Gly Gly Ala Ser Leu Asp Leu Lys Ala Cys Pro Pro Lys Pro Ser Lys
                3925                3930                3935    
Trp Ile Leu Asp Ile Thr Trp Leu Asn Leu Val Glu Leu Ser Lys Leu
            3940                3945                3950        
Arg Gln Phe Ser Asp Val Leu Asp Gln Ile Ser Arg Asn Glu Lys Met
        3955                3960                3965            
Trp Lys Ile Trp Phe Asp Lys Glu Asn Pro Glu Glu Glu Pro Leu Pro
    3970                3975                3980                
Asn Ala Tyr Asp Lys Ser Leu Asp Cys Phe Arg Arg Leu Leu Leu Ile
3985                3990                3995                4000
Arg Ser Trp Cys Pro Asp Arg Thr Ile Ala Gln Ala Arg Lys Tyr Ile
                4005                4010                4015    
Val Asp Ser Met Gly Glu Lys Tyr Ala Glu Gly Val Ile Leu Asp Leu
            4020                4025                4030        
Glu Lys Thr Trp Glu Glu Ser Asp Pro Arg Thr Pro Leu Ile Cys Leu
        4035                4040                4045            
Leu Ser Met Gly Ser Asp Pro Thr Asp Ser Ile Ile Ala Leu Gly Lys
    4050                4055                4060                
Arg Leu Lys Ile Glu Thr Arg Tyr Val Ser Met Gly Gln Gly Gln Glu
4065                4070                4075                4080
Val His Ala Arg Lys Leu Leu Gln Gln Thr Met Ala Asn Gly Gly Trp
                4085                4090                4095    
Ala Leu Leu Gln Asn Cys His Leu Gly Leu Asp Phe Met Asp Glu Leu
            4100                4105                4110        
Met Asp Ile Ile Ile Glu Thr Glu Leu Val His Asp Ala Phe Arg Leu
        4115                4120                4125            
Trp Met Thr Thr Glu Ala His Lys Gln Phe Pro Ile Thr Leu Leu Gln
    4130                4135                4140                
Met Ser Ile Lys Phe Ala Asn Asp Pro Pro Gln Gly Leu Arg Ala Gly
4145                4150                4155                4160
Leu Lys Arg Thr Tyr Ser Gly Val Ser Gln Asp Leu Leu Asp Val Ser
                4165                4170                4175    
Ser Gly Ser Gln Trp Lys Pro Met Leu Tyr Ala Val Ala Phe Leu His
            4180                4185                4190        
Ser Thr Val Gln Glu Arg Arg Lys Phe Gly Ala Leu Gly Trp Asn Ile
        4195                4200                4205            
Pro Tyr Glu Phe Asn Gln Ala Asp Phe Asn Ala Thr Val Gln Phe Ile
    4210                4215                4220                
Gln Asn His Leu Asp Asp Met Asp Val Lys Lys Gly Val Ser Trp Thr
4225                4230                4235                4240
Thr Ile Arg Tyr Met Ile Gly Glu Ile Gln Tyr Gly Gly Arg Val Thr
                4245                4250                4255    
Asp Asp Tyr Asp Lys Arg Leu Leu Asn Thr Phe Ala Lys Val Trp Phe
            4260                4265                4270        
Ser Glu Asn Met Phe Gly Pro Asp Phe Ser Phe Tyr Gln Gly Tyr Asn
        4275                4280                4285            
Ile Pro Lys Cys Ser Thr Val Asp Asn Tyr Leu Gln Tyr Ile Gln Ser
    4290                4295                4300                
Leu Pro Ala Tyr Asp Ser Pro Glu Val Phe Gly Leu His Pro Asn Ala
4305                4310                4315                4320
Asp Ile Thr Tyr Gln Ser Lys Leu Ala Lys Asp Val Leu Asp Thr Ile
                4325                4330                4335    
Leu Gly Ile Gln Pro Lys Asp Thr Ser Gly Gly Gly Asp Glu Thr Arg
            4340                4345                4350        
Glu Ala Val Val Ala Arg Leu Ala Asp Asp Met Leu Glu Lys Leu Pro
        4355                4360                4365            
Pro Asp Tyr Val Pro Phe Glu Val Lys Glu Arg Leu Gln Lys Met Gly
    4370                4375                4380                
Pro Phe Gln Pro Met Asn Ile Phe Leu Arg Gln Glu Ile Asp Arg Met
4385                4390                4395                4400
Gln Arg Val Leu Ser Leu Val Arg Ser Thr Leu Thr Glu Leu Lys Leu
                4405                4410                4415    
Ala Ile Asp Gly Thr Ile Ile Met Ser Glu Asn Leu Arg Asp Ala Leu
            4420                4425                4430        
Asp Cys Met Phe Asp Ala Arg Ile Pro Ala Trp Trp Lys Lys Ala Ser
        4435                4440                4445            
Trp Ile Ser Ser Thr Leu Gly Phe Trp Phe Thr Glu Leu Ile Glu Arg
    4450                4455                4460                
Asn Ser Gln Phe Thr Ser Trp Val Phe Asn Gly Arg Pro His Cys Phe
4465                4470                4475                4480
Trp Met Thr Gly Phe Phe Asn Pro Gln Gly Phe Leu Thr Ala Met Arg
                4485                4490                4495    
Gln Glu Ile Thr Arg Ala Asn Lys Gly Trp Ala Leu Asp Asn Met Val
            4500                4505                4510        
Leu Cys Asn Glu Val Thr Lys Trp Met Lys Asp Asp Ile Ser Ala Pro
        4515                4520                4525            
Pro Thr Glu Gly Val Tyr Val Tyr Gly Leu Tyr Leu Glu Gly Ala Gly
    4530                4535                4540                
Trp Asp Lys Arg Asn Met Lys Leu Ile Glu Ser Lys Pro Lys Val Leu
4545                4550                4555                4560
Phe Glu Leu Met Pro Val Ile Arg Ile Tyr Ala Glu Asn Asn Thr Leu
                4565                4570                4575    
Arg Asp Pro Arg Phe Tyr Ser Cys Pro Ile Tyr Lys Lys Pro Val Arg
            4580                4585                4590        
Thr Asp Leu Asn Tyr Ile Ala Ala Val Asp Leu Arg Thr Ala Gln Thr
        4595                4600                4605            
Pro Glu His Trp Val Leu Arg Gly Val Ala Leu Leu Cys Asp Val Lys
    4610                4615                4620                


<210> 2992
<211> 538
<212> PRT
<213> Homo sapiens

<400> 2992
Met Leu Gln Ile Gly Glu Asp Val Asp Tyr Leu Leu Ile Pro Arg Glu
 1               5                  10                  15      
Val Arg Leu Ala Gly Gly Val Trp Arg Val Ile Ser Lys Pro Ala Thr
            20                  25                  30          
Lys Glu Ala Glu Phe Arg Glu Arg Leu Thr Gln Phe Leu Glu Glu Glu
        35                  40                  45              
Gly Arg Thr Leu Glu Asp Val Ala Arg Ile Met Glu Lys Ser Thr Pro
    50                  55                  60                  
His Pro Pro Gln Pro Pro Lys Lys Pro Lys Glu Pro Arg Val Arg Arg
65                  70                  75                  80  
Arg Val Gln Gln Met Val Thr Pro Pro Pro Arg Leu Val Val Gly Thr
                85                  90                  95      
Tyr Asp Ser Ser Asn Ala Ser Asp Ser Glu Phe Ser Asp Phe Glu Thr
            100                 105                 110         
Ser Arg Asp Lys Ser Arg Gln Gly Pro Arg Arg Gly Lys Lys Val Arg
        115                 120                 125             
Lys Met Pro Val Ser Tyr Leu Gly Ser Lys Phe Leu Gly Ser Asp Leu
    130                 135                 140                 
Glu Ser Glu Asp Asp Glu Glu Leu Val Glu Ala Phe Leu Arg Arg Gln
145                 150                 155                 160 
Glu Lys Gln Pro Ser Ala Pro Pro Ala Arg Arg Arg Val Asn Leu Pro
                165                 170                 175     
Val Pro Met Phe Glu Asp Asn Leu Gly Pro Gln Leu Ser Lys Ala Asp
            180                 185                 190         
Arg Trp Arg Glu Tyr Val Ser Gln Val Ser Trp Gly Lys Leu Lys Arg
        195                 200                 205             
Arg Val Lys Gly Trp Ala Pro Arg Ala Gly Pro Gly Val Gly Glu Ala
    210                 215                 220                 
Arg Leu Ala Ser Thr Ala Val Glu Ser Ala Gly Val Ser Ser Ala Pro
225                 230                 235                 240 
Glu Gly Thr Ser Pro Gly Asp Arg Leu Gly Asn Ala Gly Asp Val Cys
                245                 250                 255     
Val Pro Gln Ala Ser Pro Arg Arg Trp Arg Pro Lys Ile Asn Trp Ala
            260                 265                 270         
Ser Phe Arg Arg Arg Arg Lys Glu Gln Thr Ala Pro Thr Gly Gln Gly
        275                 280                 285             
Ala Asp Ile Glu Ala Asp Gln Gly Gly Glu Ala Ala Asp Ser Gln Arg
    290                 295                 300                 
Glu Glu Ala Ile Ala Asp Gln Arg Glu Gly Ala Ala Gly Asn Gln Arg
305                 310                 315                 320 
Ala Gly Ala Pro Ala Asp Gln Gly Ala Glu Ala Ala Asp Asn Gln Arg
                325                 330                 335     
Glu Glu Ala Ala Asp Asn Gln Arg Ala Gly Ala Pro Ala Glu Glu Gly
            340                 345                 350         
Ala Glu Ala Ala Asp Asn Gln Arg Glu Glu Ala Ala Asp Asn Gln Arg
        355                 360                 365             
Ala Glu Ala Pro Ala Asp Gln Arg Ser Gln Gly Thr Asp Asn His Arg
    370                 375                 380                 
Glu Glu Ala Ala Asp Asn Gln Arg Ala Glu Ala Pro Ala Asp Gln Gly
385                 390                 395                 400 
Ser Glu Val Thr Asp Asn Gln Arg Glu Glu Ala Val His Asp Gln Arg
                405                 410                 415     
Glu Arg Ala Pro Ala Val Gln Gly Ala Asp Asn Gln Arg Ala Gln Ala
            420                 425                 430         
Arg Ala Gly Gln Arg Ala Glu Ala Ala His Asn Gln Arg Ala Gly Ala
        435                 440                 445             
Pro Gly Ile Gln Glu Ala Glu Val Ser Ala Ala Gln Gly Thr Thr Gly
    450                 455                 460                 
Thr Ala Pro Gly Ala Arg Ala Arg Lys Gln Val Lys Thr Val Arg Phe
465                 470                 475                 480 
Gln Thr Pro Gly Arg Phe Ser Trp Phe Cys Lys Arg Arg Arg Ala Phe
                485                 490                 495     
Trp His Thr Pro Arg Leu Pro Thr Leu Pro Lys Arg Val Pro Arg Ala
            500                 505                 510         
Gly Glu Ala Arg Asn Leu Arg Val Leu Arg Ala Glu Ala Arg Ala Glu
        515                 520                 525             
Ala Glu Gln Gly Glu Gln Glu Asp Gln Leu
    530                 535             


<210> 2993
<211> 315
<212> PRT
<213> Homo sapiens

<400> 2993
Val Val Leu Gly Pro Arg Gly Ala Gly Leu Pro Gly Ala Arg Ala Arg
 1               5                  10                  15      
Gly Leu Leu Cys Ser Ala Arg Pro Gly Gln Leu Pro Leu Arg Thr Pro
            20                  25                  30          
Gln Ala Val Ala Leu Ser Ser Lys Ser Gly Leu Ser Arg Gly Arg Lys
        35                  40                  45              
Val Met Leu Ser Ala Leu Gly Met Leu Ala Ala Gly Gly Ala Gly Leu
    50                  55                  60                  
Ala Val Ala Leu His Ser Ala Val Ser Ala Ser Asp Leu Glu Leu His
65                  70                  75                  80  
Pro Pro Ser Tyr Pro Trp Ser His Arg Gly Leu Leu Ser Ser Leu Asp
                85                  90                  95      
His Thr Ser Ile Arg Arg Gly Phe Gln Val Tyr Lys Gln Val Cys Ala
            100                 105                 110         
Ser Cys His Ser Met Asp Phe Val Ala Tyr Arg His Leu Val Gly Val
        115                 120                 125             
Cys Tyr Thr Glu Asp Glu Ala Lys Glu Leu Ala Ala Glu Val Glu Val
    130                 135                 140                 
Gln Asp Gly Pro Asn Glu Asp Gly Glu Met Phe Met Arg Pro Gly Lys
145                 150                 155                 160 
Leu Phe Asp Tyr Phe Pro Lys Pro Tyr Pro Asn Ser Glu Ala Ala Arg
                165                 170                 175     
Ala Ala Asn Asn Gly Ala Leu Pro Pro Asp Leu Ser Tyr Ile Val Arg
            180                 185                 190         
Ala Arg His Gly Gly Glu Asp Tyr Val Phe Ser Leu Leu Thr Gly Tyr
        195                 200                 205             
Cys Glu Pro Pro Thr Gly Val Ser Leu Arg Glu Gly Leu Tyr Phe Asn
    210                 215                 220                 
Pro Tyr Phe Pro Gly Gln Ala Ile Ala Met Ala Pro Pro Ile Tyr Thr
225                 230                 235                 240 
Asp Val Leu Glu Phe Asp Asp Gly Thr Pro Ala Thr Met Ser Gln Ile
                245                 250                 255     
Ala Lys Asp Val Cys Thr Phe Leu Arg Trp Ala Ser Glu Pro Glu His
            260                 265                 270         
Asp His Arg Lys Arg Met Gly Leu Lys Met Leu Met Met Met Ala Leu
        275                 280                 285             
Leu Val Pro Leu Val Tyr Thr Ile Lys Arg His Lys Trp Ser Val Leu
    290                 295                 300                 
Lys Ser Arg Lys Leu Ala Tyr Arg Pro Pro Lys
305                 310                 315 


<210> 2994
<211> 421
<212> PRT
<213> Homo sapiens

<400> 2994
Met Asp Gln Ala Lys Ser Ala Glu Leu Glu Phe Val Glu Ser Gly Leu
 1               5                  10                  15      
Gly Arg Cys Gly Leu Ala Phe Arg Pro Leu Ala Thr Glu Pro Arg Gly
            20                  25                  30          
Ser Ser Pro Val Gln Leu Val Ser Ser Thr Met Ser Val Arg Thr Leu
        35                  40                  45              
Pro Leu Leu Phe Leu Asn Leu Gly Gly Glu Met Leu Tyr Ile Leu Asp
    50                  55                  60                  
Gln Arg Leu Arg Ala Gln Asn Ile Arg Gly Asp Lys Ala Arg Lys Val
65                  70                  75                  80  
Leu Asn Asp Ile Ile Ser Thr Met Phe Asn Arg Lys Phe Met Glu Glu
                85                  90                  95      
Leu Phe Lys Pro Gln Glu Leu Tyr Ser Lys Lys Ala Leu Arg Thr Val
            100                 105                 110         
Tyr Glu Arg Leu Ala His Ala Ser Ile Met Lys Leu Asn Gln Ala Ser
        115                 120                 125             
Met Asp Lys Leu Tyr Asp Leu Met Thr Met Ala Phe Lys Tyr Gln Val
    130                 135                 140                 
Leu Leu Cys Pro Arg Pro Lys Asp Val Leu Leu Val Thr Phe Asn His
145                 150                 155                 160 
Leu Asp Thr Ile Lys Gly Phe Ile Arg Asp Ser Pro Thr Ile Leu Gln
                165                 170                 175     
Gln Val Asp Glu Thr Leu Arg Gln Leu Thr Glu Ile Tyr Gly Gly Leu
            180                 185                 190         
Ser Ala Gly Glu Phe Gln Leu Ile Arg Gln Thr Leu Leu Ile Phe Phe
        195                 200                 205             
Gln Asp Leu His Ile Arg Val Ser Met Phe Leu Lys Asp Lys Val Gln
    210                 215                 220                 
Asn Asn Asn Gly Arg Phe Val Leu Pro Val Ser Gly Pro Val Pro Trp
225                 230                 235                 240 
Gly Thr Glu Val Pro Gly Leu Ile Arg Met Phe Asn Asn Lys Gly Glu
                245                 250                 255     
Glu Val Lys Arg Ile Glu Phe Lys His Gly Gly Asn Tyr Val Pro Ala
            260                 265                 270         
Pro Lys Glu Gly Ser Phe Glu Leu Tyr Gly Asp Arg Val Leu Lys Leu
        275                 280                 285             
Gly Thr Asn Met Tyr Ser Val Asn Gln Pro Val Glu Thr His Val Ser
    290                 295                 300                 
Gly Ser Ser Lys Asn Leu Ala Ser Trp Thr Gln Glu Ser Ile Ala Pro
305                 310                 315                 320 
Asn Pro Leu Ala Lys Glu Glu Leu Asn Phe Leu Ala Arg Leu Met Gly
                325                 330                 335     
Gly Met Glu Ile Lys Lys Pro Ser Gly Pro Glu Pro Gly Phe Arg Leu
            340                 345                 350         
Asn Leu Phe Thr Thr Asp Glu Glu Glu Glu Gln Ala Ala Leu Thr Arg
        355                 360                 365             
Pro Glu Glu Leu Ser Tyr Glu Val Ile Asn Ile Gln Ala Thr Gln Asp
    370                 375                 380                 
Gln Gln Arg Ser Glu Glu Leu Ala Arg Ile Met Gly Glu Phe Glu Ile
385                 390                 395                 400 
Thr Glu Gln Pro Arg Leu Ser Thr Gly Lys Gly Asp Asp Leu Leu Ala
                405                 410                 415     
Met Met Asp Glu Leu
            420     


<210> 2995
<211> 983
<212> PRT
<213> Homo sapiens

<400> 2995
Lys Leu Leu Ile Gln Asp Leu Glu Asp Ile Glu Gln Arg Val Pro Val
 1               5                  10                  15      
Met Asp Ala Gln Tyr Lys Ile Ile Thr Lys Thr Ala His Leu Ile Thr
            20                  25                  30          
Lys Glu Ser Pro Gln Glu Glu Gly Lys Glu Met Phe Ala Thr Met Ser
        35                  40                  45              
Lys Leu Lys Glu Gln Leu Thr Lys Val Lys Glu Cys Tyr Ser Pro Leu
    50                  55                  60                  
Leu Tyr Glu Ser Gln Gln Leu Leu Ile Pro Leu Glu Glu Leu Glu Lys
65                  70                  75                  80  
Gln Met Thr Ser Phe Tyr Asp Ser Leu Gly Lys Ile Asn Glu Ile Ile
                85                  90                  95      
Thr Val Leu Glu Arg Glu Ala Gln Ser Ser Ala Leu Phe Lys Gln Lys
            100                 105                 110         
His Gln Glu Leu Leu Ala Cys Gln Glu Asn Cys Lys Lys Thr Leu Thr
        115                 120                 125             
Leu Ile Glu Lys Gly Ser Gln Ser Val Gln Lys Phe Val Thr Leu Ser
    130                 135                 140                 
Asn Val Leu Lys His Phe Asp Gln Thr Arg Leu Gln Arg Gln Ile Ala
145                 150                 155                 160 
Asp Ile His Val Ala Phe Gln Ser Met Val Lys Lys Thr Gly Asp Trp
                165                 170                 175     
Lys Lys His Val Glu Thr Asn Ser Arg Leu Met Lys Lys Phe Glu Glu
            180                 185                 190         
Ser Arg Ala Glu Leu Glu Lys Val Leu Arg Ile Ala Gln Glu Gly Leu
        195                 200                 205             
Glu Glu Lys Gly Asp Pro Glu Glu Leu Leu Arg Arg His Thr Glu Phe
    210                 215                 220                 
Phe Ser Gln Leu Asp Gln Arg Val Leu Asn Ala Phe Leu Lys Ala Cys
225                 230                 235                 240 
Asp Glu Leu Thr Asp Ile Leu Pro Glu Gln Glu Gln Gln Gly Leu Gln
                245                 250                 255     
Glu Ala Val Arg Lys Leu His Lys Gln Trp Lys Asp Leu Gln Gly Glu
            260                 265                 270         
Ala Pro Tyr His Leu Leu His Leu Lys Ile Asp Val Glu Lys Asn Arg
        275                 280                 285             
Phe Leu Ala Ser Val Glu Glu Cys Arg Thr Glu Leu Asp Arg Glu Thr
    290                 295                 300                 
Lys Leu Met Pro Gln Glu Gly Ser Glu Lys Ile Ile Lys Glu His Arg
305                 310                 315                 320 
Val Phe Phe Ser Asp Lys Gly Pro His His Leu Cys Glu Lys Arg Leu
                325                 330                 335     
Gln Leu Ile Glu Glu Leu Cys Val Lys Leu Pro Val Arg Asp Pro Val
            340                 345                 350         
Arg Asp Thr Pro Gly Thr Cys His Val Thr Leu Lys Glu Leu Arg Ala
        355                 360                 365             
Ala Ile Asp Ser Thr Tyr Arg Lys Leu Met Glu Asp Pro Asp Lys Trp
    370                 375                 380                 
Lys Asp Tyr Thr Ser Arg Phe Ser Glu Phe Ser Ser Trp Ile Ser Thr
385                 390                 395                 400 
Asn Glu Thr Gln Leu Lys Gly Ile Lys Gly Glu Ala Ile Asp Thr Ala
                405                 410                 415     
Asn His Gly Glu Val Lys Arg Ala Val Glu Glu Ile Arg Asn Gly Val
            420                 425                 430         
Thr Lys Arg Gly Glu Thr Leu Ser Trp Leu Lys Ser Arg Leu Lys Val
        435                 440                 445             
Leu Thr Glu Val Ser Ser Glu Asn Glu Ala Gln Lys Gln Gly Asp Glu
    450                 455                 460                 
Leu Ala Lys Leu Ser Ser Ser Phe Lys Ala Leu Val Thr Leu Leu Ser
465                 470                 475                 480 
Glu Val Glu Lys Met Leu Ser Asn Phe Gly Asp Cys Val Gln Tyr Lys
                485                 490                 495     
Glu Ile Val Lys Asn Ser Leu Glu Glu Leu Ile Ser Gly Ser Lys Glu
            500                 505                 510         
Val Gln Glu Gln Ala Glu Lys Ile Leu Asp Thr Glu Asn Leu Phe Glu
        515                 520                 525             
Ala Gln Gln Leu Leu Leu His His Gln Gln Lys Thr Lys Arg Ile Ser
    530                 535                 540                 
Ala Lys Lys Arg Asp Val Gln Gln Gln Ile Ala Gln Ala Gln Gln Gly
545                 550                 555                 560 
Glu Gly Gly Leu Pro Asp Arg Gly His Glu Glu Leu Arg Lys Leu Glu
                565                 570                 575     
Ser Thr Leu Asp Gly Leu Glu Arg Ser Arg Glu Arg Gln Glu Arg Arg
            580                 585                 590         
Ile Gln Val Thr Leu Arg Lys Trp Glu Arg Phe Glu Thr Asn Lys Glu
        595                 600                 605             
Thr Val Val Arg Tyr Leu Phe Gln Thr Gly Ser Ser His Glu Arg Phe
    610                 615                 620                 
Leu Ser Phe Ser Ser Leu Glu Ser Leu Ser Ser Glu Leu Glu Gln Thr
625                 630                 635                 640 
Lys Glu Phe Ser Lys Arg Thr Glu Ser Ile Ala Val Gln Ala Glu Asn
                645                 650                 655     
Leu Val Lys Glu Ala Ser Glu Ile Pro Leu Gly Pro Gln Asn Lys Gln
            660                 665                 670         
Leu Leu Gln Gln Gln Ala Lys Ser Ile Lys Glu Gln Val Lys Lys Leu
        675                 680                 685             
Glu Asp Thr Leu Glu Glu Asp Ile Lys Pro Met Glu Met Val Lys Thr
    690                 695                 700                 
Lys Trp Asp His Phe Gly Ser Asn Phe Glu Thr Leu Ser Val Trp Ile
705                 710                 715                 720 
Thr Glu Lys Glu Lys Glu Leu Asn Ala Leu Glu Thr Ser Ser Ser Ala
                725                 730                 735     
Met Asp Met Gln Ile Ser Gln Ile Lys Val Thr Ile Gln Glu Ile Glu
            740                 745                 750         
Ser Lys Leu Ser Ser Ile Val Gly Leu Glu Glu Glu Ala Gln Ser Phe
        755                 760                 765             
Ala Gln Phe Val Thr Thr Gly Glu Ser Ala Arg Ile Lys Ala Lys Leu
    770                 775                 780                 
Thr Gln Ile Arg Arg Tyr Gly Glu Glu Leu Arg Glu His Ala Gln Cys
785                 790                 795                 800 
Leu Glu Gly Thr Ile Leu Gly His Leu Ser Gln Gln Gln Lys Phe Glu
                805                 810                 815     
Glu Asn Leu Arg Lys Ile Gln Gln Ser Val Ser Glu Phe Glu Asp Lys
            820                 825                 830         
Leu Ala Val Pro Ile Lys Ile Cys Ser Ser Ala Thr Glu Thr Tyr Lys
        835                 840                 845             
Val Leu Gln Glu His Met Asp Leu Cys Gln Ala Leu Glu Ser Leu Ser
    850                 855                 860                 
Ser Ala Ile Thr Ala Phe Ser Ala Ser Ala Arg Lys Val Val Asn Arg
865                 870                 875                 880 
Asp Ser Cys Val Gln Glu Ala Ala Ala Leu Gln Gln Gln Tyr Glu Asp
                885                 890                 895     
Ile Leu Arg Arg Ala Lys Glu Arg Gln Thr Ala Leu Glu Asn Leu Leu
            900                 905                 910         
Ala His Trp Gln Arg Leu Glu Lys Glu Leu Ser Ser Phe Leu Thr Trp
        915                 920                 925             
Leu Glu Arg Gly Glu Ala Lys Ala Ser Ser Pro Glu Met Asp Ile Ser
    930                 935                 940                 
Ala Asp Arg Val Lys Val Glu Gly Glu Leu Gln Leu Ile Gln Ala Ser
945                 950                 955                 960 
Ser Arg Lys Cys Glu Glu Gly Lys Asn Lys Met Leu Phe Val Thr Val
                965                 970                 975     
Thr Leu Phe Lys Ile Ile Lys
            980             


<210> 2996
<211> 291
<212> PRT
<213> Homo sapiens

<400> 2996
Ala Gly Leu Ser Ala Trp Thr Leu Gln Pro Gln Trp Ile Gln Val Arg
 1               5                  10                  15      
Asn Met Ala Thr Leu Lys Asp Ile Thr Arg Arg Leu Lys Ser Ile Lys
            20                  25                  30          
Asn Ile Gln Lys Ile Thr Lys Ser Met Lys Met Val Ala Ala Ala Lys
        35                  40                  45              
Tyr Ala Arg Ala Glu Arg Glu Leu Lys Pro Ala Arg Ile Tyr Gly Leu
    50                  55                  60                  
Gly Ser Leu Ala Leu Tyr Glu Lys Ala Asp Ile Lys Gly Pro Glu Asp
65                  70                  75                  80  
Lys Lys Lys His Leu Leu Ile Gly Val Ser Ser Asp Arg Gly Leu Cys
                85                  90                  95      
Gly Ala Ile His Ser Ser Ile Ala Lys Gln Met Lys Ser Glu Val Ala
            100                 105                 110         
Thr Leu Thr Ala Ala Gly Lys Glu Val Met Leu Val Gly Ile Gly Asp
        115                 120                 125             
Lys Ile Arg Gly Ile Leu Tyr Arg Thr His Ser Asp Gln Phe Leu Val
    130                 135                 140                 
Ala Phe Lys Glu Val Gly Arg Lys Pro Pro Thr Phe Gly Asp Ala Ser
145                 150                 155                 160 
Val Ile Ala Leu Glu Leu Leu Asn Ser Gly Tyr Glu Phe Asp Glu Gly
                165                 170                 175     
Ser Ile Ile Phe Asn Lys Phe Arg Ser Val Ile Ser Tyr Lys Thr Glu
            180                 185                 190         
Glu Lys Pro Ile Phe Ser Leu Asn Thr Val Ala Ser Ala Asp Ser Met
        195                 200                 205             
Ser Ile Tyr Asp Asp Ile Asp Ala Asp Val Leu Gln Asn Tyr Gln Glu
    210                 215                 220                 
Tyr Asn Leu Ala Asn Ile Ile Tyr Tyr Ser Leu Lys Glu Ser Thr Thr
225                 230                 235                 240 
Ser Glu Gln Ser Ala Arg Met Thr Ala Met Asp Asn Ala Ser Lys Asn
                245                 250                 255     
Ala Ser Glu Met Ile Asp Lys Leu Thr Leu Thr Phe Asn Arg Thr Arg
            260                 265                 270         
Gln Ala Val Ile Thr Lys Glu Leu Ile Glu Ile Ile Ser Gly Ala Ala
        275                 280                 285             
Ala Leu Asp
    290     


<210> 2997
<211> 819
<212> PRT
<213> Homo sapiens

<400> 2997
Met Asn Leu Gln Pro Ile Phe Trp Ile Gly Leu Ile Ser Ser Val Cys
 1               5                  10                  15      
Cys Val Phe Ala Gln Thr Asp Glu Asn Arg Cys Leu Lys Ala Asn Ala
            20                  25                  30          
Lys Ser Cys Gly Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys
        35                  40                  45              
Thr Asn Ser Thr Phe Leu Gln Glu Gly Met Pro Thr Ser Ala Arg Cys
    50                  55                  60                  
Asp Asp Leu Glu Ala Leu Lys Lys Lys Gly Cys Pro Pro Asp Asp Ile
65                  70                  75                  80  
Glu Asn Pro Arg Gly Ser Lys Asp Ile Lys Lys Asn Lys Asn Val Thr
                85                  90                  95      
Asn Arg Ser Lys Gly Thr Ala Glu Lys Leu Lys Pro Glu Asp Ile Thr
            100                 105                 110         
Gln Ile Gln Pro Gln Gln Leu Val Leu Arg Leu Arg Ser Gly Glu Pro
        115                 120                 125             
Gln Thr Phe Thr Leu Lys Phe Lys Arg Ala Glu Asp Tyr Pro Ile Asp
    130                 135                 140                 
Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Glu
145                 150                 155                 160 
Asn Val Lys Ser Leu Gly Thr Asp Leu Met Asn Glu Met Arg Arg Ile
                165                 170                 175     
Thr Ser Asp Phe Arg Ile Gly Phe Gly Ser Phe Val Glu Lys Thr Val
            180                 185                 190         
Met Pro Tyr Ile Ser Thr Thr Pro Ala Lys Leu Arg Asn Pro Cys Thr
        195                 200                 205             
Ser Glu Gln Asn Cys Thr Ser Pro Phe Ser Tyr Lys Asn Val Leu Ser
    210                 215                 220                 
Leu Thr Asn Lys Gly Glu Val Phe Asn Glu Leu Val Gly Lys Gln Arg
225                 230                 235                 240 
Ile Ser Gly Asn Leu Asp Ser Pro Glu Gly Gly Phe Asp Ala Ile Met
                245                 250                 255     
Gln Val Ala Val Cys Gly Ser Leu Ile Gly Trp Arg Asn Val Thr Arg
            260                 265                 270         
Leu Leu Val Phe Ser Thr Asp Ala Gly Phe His Phe Ala Gly Asp Gly
        275                 280                 285             
Lys Leu Gly Gly Ile Val Leu Pro Asn Asp Gly Gln Cys His Leu Glu
    290                 295                 300                 
Asn Asn Met Tyr Thr Met Ser His Tyr Tyr Asp Tyr Pro Ser Ile Ala
305                 310                 315                 320 
His Leu Val Gln Lys Leu Ser Glu Asn Asn Ile Gln Thr Ile Phe Ala
                325                 330                 335     
Val Thr Glu Glu Phe Gln Pro Val Tyr Lys Glu Leu Lys Asn Leu Ile
            340                 345                 350         
Pro Lys Ser Ala Val Gly Thr Leu Ser Ala Asn Ser Ser Asn Val Ile
        355                 360                 365             
Gln Leu Ile Ile Asp Ala Tyr Asn Ser Leu Ser Ser Glu Val Ile Leu
    370                 375                 380                 
Glu Asn Gly Lys Leu Ser Glu Gly Val Thr Ile Ser Tyr Lys Ser Tyr
385                 390                 395                 400 
Cys Lys Asn Gly Val Asn Gly Thr Gly Glu Asn Gly Arg Lys Cys Ser
                405                 410                 415     
Asn Ile Ser Ile Gly Asp Glu Val Gln Phe Glu Ile Ser Ile Thr Ser
            420                 425                 430         
Asn Lys Cys Pro Lys Lys Asp Ser Asp Ser Phe Lys Ile Arg Pro Leu
        435                 440                 445             
Gly Phe Thr Glu Glu Val Glu Val Ile Leu Gln Tyr Ile Cys Glu Cys
    450                 455                 460                 
Glu Cys Gln Ser Glu Gly Ile Pro Glu Ser Pro Lys Cys His Glu Gly
465                 470                 475                 480 
Asn Gly Thr Phe Glu Cys Gly Ala Cys Arg Cys Asn Glu Gly Arg Val
                485                 490                 495     
Gly Arg His Cys Glu Cys Ser Thr Asp Glu Val Asn Ser Glu Asp Met
            500                 505                 510         
Asp Ala Tyr Cys Arg Lys Glu Asn Ser Ser Glu Ile Cys Ser Asn Asn
        515                 520                 525             
Gly Glu Cys Val Cys Gly Gln Cys Val Cys Arg Lys Arg Asp Asn Thr
    530                 535                 540                 
Asn Glu Ile Tyr Ser Gly Lys Phe Cys Glu Cys Asp Asn Phe Asn Cys
545                 550                 555                 560 
Asp Arg Ser Asn Gly Leu Ile Cys Gly Gly Asn Gly Val Cys Lys Cys
                565                 570                 575     
Arg Val Cys Glu Cys Asn Pro Asn Tyr Thr Gly Ser Ala Cys Asp Cys
            580                 585                 590         
Ser Leu Asp Thr Ser Thr Cys Glu Ala Ser Asn Gly Gln Ile Cys Asn
        595                 600                 605             
Gly Arg Gly Ile Cys Glu Cys Gly Val Cys Lys Cys Thr Asp Pro Lys
    610                 615                 620                 
Phe Gln Gly Gln Thr Cys Glu Met Cys Gln Thr Cys Leu Gly Val Cys
625                 630                 635                 640 
Ala Glu His Lys Glu Cys Val Gln Cys Arg Ala Phe Asn Lys Gly Glu
                645                 650                 655     
Lys Lys Asp Thr Cys Thr Gln Glu Cys Ser Tyr Phe Asn Ile Thr Lys
            660                 665                 670         
Val Glu Ser Arg Asp Lys Leu Pro Gln Pro Val Gln Pro Asp Pro Val
        675                 680                 685             
Ser His Cys Lys Glu Lys Asp Val Asp Asp Cys Trp Phe Tyr Phe Thr
    690                 695                 700                 
Tyr Ser Val Asn Gly Asn Asn Glu Val Met Val His Val Val Glu Asn
705                 710                 715                 720 
Pro Glu Cys Pro Thr Gly Pro Asp Ile Ile Pro Ile Val Ala Gly Val
                725                 730                 735     
Val Ala Gly Ile Val Leu Ile Gly Leu Ala Leu Leu Leu Ile Trp Lys
            740                 745                 750         
Leu Leu Met Ile Ile His Asp Arg Arg Glu Phe Ala Lys Phe Glu Lys
        755                 760                 765             
Glu Lys Met Asn Ala Lys Trp Asp Thr Pro Gly Val Gln Trp Cys Asp
    770                 775                 780                 
Ile Ser Ser Leu Gln Pro Leu Thr Ser Arg Phe Gln Gln Phe Ser Cys
785                 790                 795                 800 
Leu Ser Leu Pro Ser Thr Trp Asp Tyr Arg Val Lys Ile Leu Phe Ile
                805                 810                 815     
Arg Val Pro
            


<210> 2998
<211> 913
<212> PRT
<213> Homo sapiens

<400> 2998
Met Asn Glu Ala Met Ala Thr Asp Ser Pro Arg Arg Pro Ser Arg Cys
 1               5                  10                  15      
Thr Gly Gly Val Val Val Arg Pro Gln Ala Val Thr Lys Gln Ser Tyr
            20                  25                  30          
Met Glu Ser Val Val Thr Phe Leu Gln Asp Val Val Pro Gln Ala Tyr
        35                  40                  45              
Ser Gly Thr Pro Leu Thr Glu Glu Lys Glu Lys Ile Val Trp Val Arg
    50                  55                  60                  
Phe Glu Asn Ala Asp Leu Asn Asp Thr Ser Arg Asn Leu Glu Phe His
65                  70                  75                  80  
Glu Ile His Ser Thr Gly Ser Glu Pro Pro Leu Leu Ile Met Ile Gly
                85                  90                  95      
Tyr Ser Asp Gly Met Gln Val Trp Ser Ile Pro Ile Ser Gly Glu Ala
            100                 105                 110         
Gln Glu Leu Phe Ser Val Arg His Gly Pro Ile Arg Ala Ala Lys Ile
        115                 120                 125             
Leu Pro Ala Pro Gln Phe Gly Ala Gln Lys Cys Asp Asn Phe Ala Glu
    130                 135                 140                 
Lys Arg Pro Leu Leu Gly Val Cys Lys Ser Ile Gly Ser Ser Gly Thr
145                 150                 155                 160 
Ser Pro Pro Tyr Cys Cys Val Asp Leu Tyr Ser Leu Arg Thr Gly Glu
                165                 170                 175     
Met Val Lys Ser Ile Gln Phe Lys Thr Pro Ile Tyr Asp Leu His Cys
            180                 185                 190         
Asn Lys Arg Ile Leu Val Val Val Leu Gln Glu Lys Ile Ala Ala Phe
        195                 200                 205             
Asp Ser Cys Thr Phe Thr Lys Lys Phe Phe Val Thr Ser Cys Tyr Pro
    210                 215                 220                 
Cys Pro Gly Pro Asn Met Asn Pro Ile Ala Leu Gly Ser Arg Trp Leu
225                 230                 235                 240 
Ala Tyr Ala Glu Asn Lys Leu Ile Arg Cys His Gln Ser Arg Gly Gly
                245                 250                 255     
Ala Cys Gly Asp Asn Ile Gln Ser Tyr Thr Ala Thr Val Ile Ser Ala
            260                 265                 270         
Ala Lys Thr Leu Lys Ser Gly Leu Thr Met Val Gly Lys Val Val Thr
        275                 280                 285             
Gln Leu Thr Gly Thr Leu Pro Ser Gly Val Thr Glu Asp Asp Val Ala
    290                 295                 300                 
Ile His Ser Asn Ser Arg Arg Ser Pro Leu Val Pro Gly Ile Ile Thr
305                 310                 315                 320 
Val Ile Asp Thr Glu Thr Val Gly Glu Gly Gln Val Leu Val Ser Glu
                325                 330                 335     
Asp Ser Asp Ser Asp Gly Ile Val Ala His Phe Pro Ala His Glu Lys
            340                 345                 350         
Pro Val Cys Cys Met Ala Phe Asn Thr Ser Gly Met Leu Leu Val Thr
        355                 360                 365             
Thr Asp Thr Leu Gly His Asp Phe His Val Phe Gln Ile Leu Thr His
    370                 375                 380                 
Pro Trp Ser Ser Ser Gln Cys Ala Val His His Leu Tyr Thr Leu His
385                 390                 395                 400 
Arg Gly Glu Thr Glu Ala Lys Val Gln Asp Ile Cys Phe Ser His Asp
                405                 410                 415     
Cys Arg Trp Val Val Val Ser Thr Leu Arg Gly Thr Ser His Val Phe
            420                 425                 430         
Pro Ile Asn Pro Tyr Gly Gly Gln Pro Cys Val Arg Thr His Met Ser
        435                 440                 445             
Pro Arg Val Val Asn Arg Met Ser Arg Phe Gln Lys Ser Ala Gly Leu
    450                 455                 460                 
Glu Glu Ile Glu Gln Glu Leu Thr Ser Lys Gln Gly Gly Arg Cys Ser
465                 470                 475                 480 
Pro Val Pro Gly Leu Ser Ser Ser Pro Ser Gly Ser Pro Leu His Gly
                485                 490                 495     
Lys Leu Asn Ser Gln Asp Ser Tyr Asn Asn Phe Thr Asn Asn Asn Pro
            500                 505                 510         
Gly Asn Pro Arg Leu Ser Pro Leu Pro Ser Leu Met Val Val Met Pro
        515                 520                 525             
Leu Ala Gln Ile Lys Gln Pro Met Thr Leu Gly Thr Ile Thr Lys Arg
    530                 535                 540                 
Thr Gly Lys Val Lys Pro Pro Pro Gln Ile Ser Pro Ser Lys Ser Met
545                 550                 555                 560 
Gly Gly Glu Phe Cys Val Ala Ala Ile Phe Gly Thr Ser Arg Ser Trp
                565                 570                 575     
Phe Ala Asn Asn Ala Gly Leu Lys Arg Glu Lys Asp Gln Ser Lys Gln
            580                 585                 590         
Val Val Val Glu Ser Leu Tyr Ile Ile Ser Cys Tyr Gly Thr Leu Val
        595                 600                 605             
Glu His Met Met Glu Pro Arg Pro Leu Ser Thr Ala Pro Lys Ile Ser
    610                 615                 620                 
Asp Asp Thr Pro Leu Glu Met Met Thr Ser Pro Arg Ala Ser Trp Thr
625                 630                 635                 640 
Leu Val Arg Thr Pro Gln Trp Asn Glu Leu Gln Pro Pro Phe Asn Ala
                645                 650                 655     
Asn His Pro Leu Leu Leu Ala Ala Asp Ala Val Gln Tyr Tyr Gln Phe
            660                 665                 670         
Leu Leu Ala Gly Leu Val Pro Pro Gly Ser Pro Gly Pro Ile Thr Arg
        675                 680                 685             
His Gly Ser Tyr Asp Ser Leu Ala Ser Asp His Ser Gly Gln Glu Asp
    690                 695                 700                 
Glu Glu Trp Leu Ser Gln Val Glu Ile Val Thr His Thr Gly Pro His
705                 710                 715                 720 
Arg Arg Leu Trp Met Gly Pro Gln Phe Gln Phe Lys Thr Ile His Pro
                725                 730                 735     
Ser Gly Gln Thr Thr Val Ile Ser Ser Ser Ser Ser Val Leu Gln Ser
            740                 745                 750         
His Gly Pro Ser Asp Thr Pro Gln Pro Leu Leu Asp Phe Asp Thr Asp
        755                 760                 765             
Asp Leu Asp Leu Asn Ser Leu Arg Ile Gln Pro Val Arg Ser Asp Pro
    770                 775                 780                 
Val Ser Met Pro Gly Ser Ser Arg Pro Val Ser Asp Arg Arg Gly Val
785                 790                 795                 800 
Ser Thr Val Ile Asp Ala Ala Ser Gly Thr Phe Asp Arg Ser Val Thr
                805                 810                 815     
Leu Leu Glu Val Cys Gly Ser Trp Pro Glu Gly Phe Gly Leu Arg His
            820                 825                 830         
Met Ser Ser Met Glu His Thr Glu Glu Gly Leu Arg Glu Arg Leu Ala
        835                 840                 845             
Asp Ala Met Ala Glu Ser Pro Ser Arg Asp Val Val Gly Ser Gly Thr
    850                 855                 860                 
Glu Leu Gln Arg Glu Gly Ser Ile Glu Thr Leu Ser Asn Ser Ser Gly
865                 870                 875                 880 
Ser Thr Ser Gly Ser Ile Pro Arg Asn Phe Asp Gly Tyr Arg Ser Pro
                885                 890                 895     
Leu Pro Thr Asn Glu Ser Gln Pro Leu Ser Leu Phe Pro Thr Gly Phe
            900                 905                 910         
Pro
    


<210> 2999
<211> 726
<212> PRT
<213> Homo sapiens

<400> 2999
Met Glu Asp Arg Leu His Met Asp Asn Gly Leu Val Pro Gln Lys Ile
 1               5                  10                  15      
Val Ser Val His Leu Gln Asp Ser Thr Leu Lys Glu Val Lys Asp Gln
            20                  25                  30          
Val Ser Asn Lys Gln Ala Gln Ile Leu Glu Pro Lys Pro Glu Pro Ser
        35                  40                  45              
Leu Glu Ile Lys Pro Glu Gln Asp Gly Met Glu His Val Gly Arg Asp
    50                  55                  60                  
Asp Pro Lys Ala Leu Gly Glu Glu Pro Lys Gln Arg Arg Gly Ser Ala
65                  70                  75                  80  
Ser Gly Ser Glu Pro Ala Gly Asp Ser Asp Arg Gly Gly Gly Pro Val
                85                  90                  95      
Glu His Tyr His Leu His Leu Ser Ser Cys His Glu Cys Leu Glu Leu
            100                 105                 110         
Glu Asn Ser Thr Ile Glu Ser Val Lys Phe Ala Ser Ala Glu Asn Ile
        115                 120                 125             
Pro Asp Leu Pro Tyr Asp Tyr Ser Ser Ser Leu Glu Ser Val Ala Asp
    130                 135                 140                 
Glu Thr Ser Pro Glu Arg Glu Gly Arg Arg Val Asn Leu Thr Gly Lys
145                 150                 155                 160 
Ala Pro Asn Ile Leu Leu Tyr Val Gly Ser Asp Ser Gln Glu Ala Leu
                165                 170                 175     
Gly Arg Phe His Glu Val Arg Ser Val Leu Ala Asp Cys Val Asp Ile
            180                 185                 190         
Asp Ser Tyr Ile Leu Tyr His Leu Leu Glu Asp Ser Ala Leu Arg Asp
        195                 200                 205             
Pro Trp Thr Asp Asn Cys Leu Leu Leu Val Ile Ala Thr Arg Glu Ser
    210                 215                 220                 
Ile Pro Glu Asp Leu Tyr Gln Lys Phe Met Ala Tyr Leu Ser Gln Gly
225                 230                 235                 240 
Gly Lys Val Leu Gly Leu Ser Ser Ser Phe Thr Phe Gly Gly Phe Gln
                245                 250                 255     
Val Thr Ser Lys Gly Ala Leu His Lys Thr Val Gln Asn Leu Val Phe
            260                 265                 270         
Ser Lys Ala Asp Gln Ser Glu Val Lys Leu Ser Val Leu Ser Ser Gly
        275                 280                 285             
Cys Arg Tyr Gln Glu Gly Pro Val Arg Leu Ser Pro Gly Arg Leu Gln
    290                 295                 300                 
Gly His Leu Glu Asn Glu Asp Lys Asp Arg Met Ile Val His Val Pro
305                 310                 315                 320 
Phe Gly Thr Arg Gly Gly Glu Ala Val Leu Cys Gln Val His Leu Glu
                325                 330                 335     
Leu Pro Pro Ser Ser Asn Ile Val Gln Thr Pro Glu Asp Phe Asn Leu
            340                 345                 350         
Leu Lys Ser Ser Asn Phe Arg Arg Tyr Glu Val Leu Arg Glu Ile Leu
        355                 360                 365             
Thr Thr Leu Gly Leu Ser Cys Asp Met Lys Gln Val Pro Ala Leu Thr
    370                 375                 380                 
Pro Leu Tyr Leu Leu Ser Ala Ala Glu Glu Ile Arg Asp Pro Leu Met
385                 390                 395                 400 
Gln Trp Leu Gly Lys His Val Asp Ser Glu Gly Glu Ile Lys Ser Gly
                405                 410                 415     
Gln Leu Ser Leu Arg Phe Val Ser Ser Tyr Val Ser Glu Val Glu Ile
            420                 425                 430         
Thr Pro Ser Cys Ile Pro Val Val Thr Asn Met Glu Ala Phe Ser Ser
        435                 440                 445             
Glu His Phe Asn Leu Glu Ile Tyr Arg Gln Asn Leu Gln Thr Lys Gln
    450                 455                 460                 
Leu Gly Lys Val Ile Leu Phe Ala Glu Val Thr Pro Thr Thr Met Arg
465                 470                 475                 480 
Leu Leu Asp Gly Leu Met Phe Gln Thr Pro Gln Glu Met Gly Leu Ile
                485                 490                 495     
Val Ile Ala Ala Arg Gln Thr Glu Gly Lys Gly Arg Gly Gly Asn Val
            500                 505                 510         
Trp Leu Ser Pro Val Gly Cys Ala Leu Ser Thr Leu Leu Ile Ser Ile
        515                 520                 525             
Pro Leu Arg Ser Gln Leu Gly Gln Arg Ile Pro Phe Val Gln His Leu
    530                 535                 540                 
Met Ser Val Ala Val Val Glu Ala Val Arg Ser Ile Pro Lys Tyr Gln
545                 550                 555                 560 
Asp Ile Asn Leu Arg Val Lys Trp Pro Asn Asp Ile Tyr Tyr Ser Asp
                565                 570                 575     
Leu Met Lys Ile Gly Gly Val Leu Val Asn Ser Thr Leu Met Gly Glu
            580                 585                 590         
Thr Phe Tyr Ile Leu Ile Gly Cys Gly Phe Asn Val Thr Asn Ser Asn
        595                 600                 605             
Pro Thr Ile Cys Ile Asn Asp Leu Ile Thr Glu Tyr Asn Lys Gln His
    610                 615                 620                 
Lys Ala Glu Leu Lys Pro Leu Arg Ala Asp Tyr Leu Ile Ala Arg Val
625                 630                 635                 640 
Val Thr Val Leu Glu Lys Leu Ile Lys Glu Phe Gln Asp Lys Gly Pro
                645                 650                 655     
Asn Ser Val Leu Pro Leu Tyr Tyr Arg Tyr Trp Val His Ser Gly Gln
            660                 665                 670         
Gln Val His Leu Gly Ser Ala Glu Gly Pro Lys Val Ser Ile Val Gly
        675                 680                 685             
Leu Asp Asp Ser Gly Phe Leu Gln Val His Gln Glu Gly Gly Glu Val
    690                 695                 700                 
Val Thr Val His Pro Asp Gly Asn Ser Phe Asp Met Leu Arg Asn Leu
705                 710                 715                 720 
Ile Leu Pro Lys Arg Arg
                725     


<210> 3000
<211> 547
<212> PRT
<213> Homo sapiens

<400> 3000
Met Ser Ser Ser Pro Trp Glu Pro Ala Thr Leu Arg Arg Val Phe Val
 1               5                  10                  15      
Val Gly Val Gly Met Thr Lys Phe Val Lys Pro Gly Ala Glu Asn Ser
            20                  25                  30          
Arg Asp Tyr Pro Asp Leu Ala Glu Glu Ala Gly Lys Lys Ala Leu Ala
        35                  40                  45              
Asp Ala Gln Ile Pro Tyr Ser Ala Val Asp Gln Ala Cys Val Gly Tyr
    50                  55                  60                  
Val Phe Gly Asp Ser Thr Cys Gly Gln Arg Ala Ile Tyr His Ser Leu
65                  70                  75                  80  
Gly Met Thr Gly Ile Pro Ile Ile Asn Val Asn Asn Asn Cys Ala Thr
                85                  90                  95      
Gly Ser Thr Ala Leu Phe Met Ala Arg Gln Leu Ile Gln Gly Gly Val
            100                 105                 110         
Ala Glu Cys Val Leu Ala Leu Gly Phe Glu Lys Met Ser Lys Gly Ser
        115                 120                 125             
Leu Gly Ile Lys Phe Ser Asp Arg Thr Ile Pro Thr Asp Lys His Val
    130                 135                 140                 
Asp Leu Leu Ile Asn Lys Tyr Gly Leu Ser Ala His Pro Val Ala Pro
145                 150                 155                 160 
Gln Met Phe Gly Tyr Ala Gly Lys Glu His Met Glu Lys Tyr Gly Thr
                165                 170                 175     
Lys Ile Glu His Phe Ala Lys Ile Gly Trp Lys Asn His Lys His Ser
            180                 185                 190         
Val Asn Asn Pro Tyr Ser Gln Phe Gln Asp Glu Tyr Ser Leu Asp Glu
        195                 200                 205             
Val Met Ala Ser Lys Glu Val Phe Asp Phe Leu Thr Ile Leu Gln Cys
    210                 215                 220                 
Cys Pro Thr Ser Asp Gly Ala Ala Ala Ala Ile Leu Ala Ser Glu Ala
225                 230                 235                 240 
Phe Val Gln Lys Tyr Gly Leu Gln Ser Lys Ala Val Glu Ile Leu Ala
                245                 250                 255     
Gln Glu Met Met Thr Asp Leu Pro Ser Ser Phe Glu Glu Lys Ser Ile
            260                 265                 270         
Ile Lys Met Val Gly Phe Asp Met Ser Lys Glu Ala Ala Arg Lys Cys
        275                 280                 285             
Tyr Glu Lys Ser Gly Leu Thr Pro Asn Asp Ile Asp Val Ile Glu Leu
    290                 295                 300                 
His Asp Cys Phe Ser Thr Asn Glu Leu Leu Thr Tyr Glu Ala Leu Gly
305                 310                 315                 320 
Leu Cys Pro Glu Gly Gln Gly Ala Thr Leu Val Asp Arg Gly Asp Asn
                325                 330                 335     
Thr Tyr Gly Gly Lys Trp Val Ile Asn Pro Ser Gly Gly Leu Ile Ser
            340                 345                 350         
Lys Gly His Pro Leu Gly Ala Thr Gly Leu Ala Gln Cys Ala Glu Leu
        355                 360                 365             
Cys Trp Gln Leu Arg Gly Glu Ala Gly Lys Arg Gln Val Pro Gly Ala
    370                 375                 380                 
Lys Val Ala Leu Gln His Asn Leu Gly Ile Gly Gly Ala Val Val Val
385                 390                 395                 400 
Thr Leu Tyr Lys Met Gly Phe Pro Glu Ala Ala Ser Ser Phe Arg Thr
                405                 410                 415     
His Gln Ile Glu Ala Val Pro Thr Ser Ser Ala Ser Asp Gly Phe Lys
            420                 425                 430         
Ala Asn Leu Val Phe Lys Glu Ile Glu Lys Lys Leu Glu Glu Glu Gly
        435                 440                 445             
Glu Gln Phe Val Lys Lys Ile Gly Gly Ile Phe Ala Phe Lys Val Lys
    450                 455                 460                 
Asp Gly Pro Gly Gly Lys Glu Ala Thr Trp Val Val Asp Val Lys Asn
465                 470                 475                 480 
Gly Lys Gly Ser Val Leu Pro Asn Ser Asp Lys Lys Ala Asp Cys Thr
                485                 490                 495     
Ile Thr Met Ala Asp Ser Asp Phe Leu Ala Leu Met Thr Gly Lys Met
            500                 505                 510         
Asn Pro Gln Ser Ala Phe Phe Gln Gly Lys Leu Lys Ile Thr Gly Asn
        515                 520                 525             
Met Gly Leu Ala Met Lys Leu Gln Asn Leu Gln Leu Gln Pro Gly Asn
    530                 535                 540                 
Ala Lys Leu
545         


<210> 3001
<211> 616
<212> PRT
<213> Homo sapiens

<400> 3001
Met Pro Phe Thr Leu His Leu Arg Ser Arg Leu Pro Ser Ala Ile Arg
 1               5                  10                  15      
Ser Leu Ile Leu Gln Lys Lys Pro Asn Ile Arg Asn Thr Ser Ser Met
            20                  25                  30          
Ala Gly Glu Leu Arg Pro Ala Ser Leu Val Val Leu Pro Arg Ser Leu
        35                  40                  45              
Ala Pro Ala Phe Glu Arg Phe Cys Gln Val Asn Thr Gly Pro Leu Pro
    50                  55                  60                  
Leu Leu Gly Gln Ser Glu Pro Glu Lys Trp Met Leu Pro Pro Gln Gly
65                  70                  75                  80  
Ala Ile Ser Glu Thr Arg Met Gly His Pro Gln Phe Trp Lys Tyr Glu
                85                  90                  95      
Phe Gly Ala Cys Thr Gly Ser Leu Ala Ser Leu Glu Gln Tyr Ser Glu
            100                 105                 110         
Gln Leu Lys Asp Met Val Ala Phe Phe Leu Gly Cys Ser Phe Ser Leu
        115                 120                 125             
Glu Glu Ala Leu Glu Lys Ala Gly Leu Pro Arg Arg Asp Pro Ala Gly
    130                 135                 140                 
His Ser Gln Thr Thr Val Pro Cys Val Thr His Ala Gly Phe Cys Cys
145                 150                 155                 160 
Pro Leu Val Val Thr Met Arg Pro Ile Pro Lys Asp Lys Leu Glu Gly
                165                 170                 175     
Leu Val Arg Ala Cys Cys Ser Leu Gly Gly Glu Gln Gly Gln Pro Val
            180                 185                 190         
His Met Gly Asp Pro Glu Leu Leu Gly Ile Lys Glu Leu Ser Lys Pro
        195                 200                 205             
Ala Tyr Gly Asp Ala Met Val Cys Pro Pro Gly Glu Val Pro Val Phe
    210                 215                 220                 
Trp Pro Ser Pro Leu Thr Ser Leu Gly Ala Val Ser Ser Cys Glu Thr
225                 230                 235                 240 
Pro Leu Ala Phe Ala Ser Ile Pro Gly Cys Thr Val Met Thr Asp Leu
                245                 250                 255     
Lys Asp Ala Lys Ala Pro Pro Gly Cys Leu Thr Pro Glu Arg Ile Pro
            260                 265                 270         
Glu Val His His Ile Ser Gln Asp Pro Leu His Tyr Ser Ile Ala Ser
        275                 280                 285             
Val Ser Ala Ser Gln Lys Ile Arg Glu Leu Glu Ser Met Ile Gly Ile
    290                 295                 300                 
Asp Pro Gly Asn Arg Gly Ile Gly His Leu Leu Cys Lys Asp Glu Leu
305                 310                 315                 320 
Leu Lys Ala Ser Leu Ser Leu Ser His Ala Arg Ser Val Leu Ile Thr
                325                 330                 335     
Thr Gly Phe Pro Thr His Phe Asn His Glu Pro Pro Glu Glu Thr Asp
            340                 345                 350         
Gly Pro Pro Gly Ala Val Ala Leu Val Ala Phe Leu Gln Ala Leu Glu
        355                 360                 365             
Lys Glu Val Ala Ile Ile Val Asp Gln Arg Ala Trp Asn Leu His Gln
    370                 375                 380                 
Lys Ile Val Glu Asp Ala Val Glu Gln Gly Val Leu Lys Thr Gln Ile
385                 390                 395                 400 
Pro Ile Leu Thr Tyr Gln Gly Gly Ser Val Glu Ala Ala Gln Ala Phe
                405                 410                 415     
Leu Cys Lys Asn Gly Asp Pro Gln Thr Pro Arg Phe Asp His Leu Val
            420                 425                 430         
Ala Ile Glu Arg Ala Gly Arg Ala Ala Asp Gly Asn Tyr Tyr Asn Ala
        435                 440                 445             
Arg Lys Met Asn Ile Lys His Leu Val Asp Pro Ile Asp Asp Leu Phe
    450                 455                 460                 
Leu Ala Ala Lys Lys Ile Pro Gly Ile Ser Ser Thr Gly Val Gly Asp
465                 470                 475                 480 
Gly Gly Asn Glu Leu Gly Met Gly Lys Val Lys Glu Ala Val Arg Arg
                485                 490                 495     
His Ile Arg His Gly Asp Val Ile Ala Cys Asp Val Glu Ala Asp Phe
            500                 505                 510         
Ala Val Ile Ala Gly Val Ser Asn Trp Gly Gly Tyr Ala Leu Ala Cys
        515                 520                 525             
Ala Leu Tyr Ile Leu Tyr Ser Cys Ala Val His Ser Gln Tyr Leu Arg
    530                 535                 540                 
Lys Ala Val Gly Pro Ser Arg Ala Pro Gly Asp Gln Ala Trp Thr Gln
545                 550                 555                 560 
Ala Leu Pro Ser Val Ile Lys Glu Glu Lys Met Leu Gly Ile Leu Val
                565                 570                 575     
Gln His Lys Val Arg Ser Gly Val Ser Gly Ile Val Gly Met Glu Val
            580                 585                 590         
Asp Gly Leu Pro Phe His Asn Thr His Ala Glu Met Ile Gln Lys Leu
        595                 600                 605             
Val Asp Val Thr Thr Ala Gln Val
    610                 615     


<210> 3002
<211> 740
<212> PRT
<213> Homo sapiens

<400> 3002
Met Ala Ser His Leu Arg Pro Pro Ser Pro Leu Leu Val Arg Val Tyr
 1               5                  10                  15      
Lys Ser Gly Pro Arg Val Arg Arg Lys Leu Glu Ser Tyr Phe Gln Ser
            20                  25                  30          
Ser Lys Ser Ser Gly Gly Gly Glu Cys Thr Val Ser Thr Gln Glu His
        35                  40                  45              
Glu Ala Pro Gly Thr Phe Arg Val Glu Phe Ser Glu Arg Ala Ala Lys
    50                  55                  60                  
Glu Arg Val Leu Lys Lys Gly Glu His Gln Ile Leu Val Asp Glu Lys
65                  70                  75                  80  
Pro Val Pro Ile Phe Leu Val Pro Thr Glu Asn Ser Ile Lys Lys Asn
                85                  90                  95      
Thr Arg Pro Gln Ile Ser Ser Leu Thr Gln Ser Gln Ala Glu Thr Pro
            100                 105                 110         
Ser Gly Asp Met His Gln His Glu Gly His Ile Pro Asn Ala Val Asp
        115                 120                 125             
Ser Cys Leu Gln Lys Ile Phe Leu Thr Val Thr Ala Asp Leu Asn Cys
    130                 135                 140                 
Asn Leu Phe Ser Lys Glu Gln Arg Ala Tyr Ile Thr Thr Leu Cys Pro
145                 150                 155                 160 
Ser Ile Arg Lys Met Glu Gly His Asp Gly Ile Glu Lys Val Cys Gly
                165                 170                 175     
Asp Phe Gln Asp Ile Glu Arg Ile His Gln Phe Leu Ser Glu Gln Phe
            180                 185                 190         
Leu Glu Ser Glu Gln Lys Gln Gln Phe Ser Pro Ser Met Thr Glu Arg
        195                 200                 205             
Lys Pro Leu Ser Gln Gln Glu Arg Asp Ser Cys Ile Ser Pro Ser Glu
    210                 215                 220                 
Pro Glu Thr Lys Ala Glu Gln Lys Ser Asn Tyr Phe Glu Val Pro Leu
225                 230                 235                 240 
Pro Tyr Phe Glu Tyr Phe Lys Tyr Ile Cys Pro Asp Lys Ile Asn Ser
                245                 250                 255     
Ile Glu Lys Arg Phe Gly Val Asn Ile Glu Ile Gln Glu Ser Ser Pro
            260                 265                 270         
Asn Met Val Cys Leu Asp Phe Thr Ser Ser Arg Ser Gly Asp Leu Glu
        275                 280                 285             
Ala Ala Arg Glu Ser Phe Ala Ser Glu Phe Gln Lys Asn Thr Glu Pro
    290                 295                 300                 
Leu Lys Gln Glu Cys Val Ser Leu Ala Asp Ser Lys Gln Ala Asn Lys
305                 310                 315                 320 
Phe Lys Gln Glu Leu Asn His Gln Phe Thr Lys Leu Leu Ile Lys Glu
                325                 330                 335     
Lys Gly Gly Glu Leu Thr Leu Leu Gly Thr Gln Asp Asp Ile Ser Ala
            340                 345                 350         
Ala Lys Gln Lys Ile Ser Glu Ala Phe Val Lys Ile Pro Val Lys Leu
        355                 360                 365             
Phe Ala Ala Asn Tyr Met Met Asn Val Ile Glu Val Asp Ser Ala His
    370                 375                 380                 
Tyr Lys Leu Leu Glu Thr Glu Leu Leu Gln Glu Ile Ser Glu Ile Glu
385                 390                 395                 400 
Lys Arg Tyr Asp Ile Cys Ser Lys Val Ser Glu Lys Gly Gln Lys Thr
                405                 410                 415     
Cys Ile Leu Phe Glu Ser Lys Asp Arg Gln Val Asp Leu Ser Val His
            420                 425                 430         
Ala Tyr Ala Ser Phe Ile Asp Ala Phe Gln His Ala Ser Cys Gln Leu
        435                 440                 445             
Met Arg Glu Val Leu Leu Leu Lys Ser Leu Gly Lys Glu Arg Lys His
    450                 455                 460                 
Leu His Gln Thr Lys Phe Ala Asp Asp Phe Arg Lys Arg His Pro Asn
465                 470                 475                 480 
Val His Phe Val Leu Asn Gln Glu Ser Met Thr Leu Thr Gly Leu Pro
                485                 490                 495     
Asn His Leu Ala Lys Ala Lys Gln Tyr Val Leu Lys Gly Gly Gly Met
            500                 505                 510         
Ser Ser Leu Ala Gly Lys Lys Leu Lys Glu Gly His Glu Thr Pro Met
        515                 520                 525             
Asp Ile Asp Ser Asp Asp Ser Lys Ala Ala Ser Pro Pro Leu Lys Gly
    530                 535                 540                 
Ser Val Ser Ser Glu Ala Ser Glu Leu Asp Lys Lys Glu Lys Gly Ile
545                 550                 555                 560 
Cys Val Ile Cys Met Asp Thr Ile Ser Asn Lys Lys Val Leu Pro Lys
                565                 570                 575     
Cys Lys His Glu Phe Cys Ala Pro Cys Ile Asn Lys Ala Met Ser Tyr
            580                 585                 590         
Lys Pro Ile Cys Pro Thr Cys Gln Thr Ser Tyr Gly Ile Gln Lys Gly
        595                 600                 605             
Asn Gln Pro Glu Gly Ser Met Val Phe Thr Val Ser Arg Asp Ser Leu
    610                 615                 620                 
Pro Gly Tyr Glu Ser Phe Gly Thr Ile Val Ile Thr Tyr Ser Met Lys
625                 630                 635                 640 
Ala Gly Ile Gln Thr Glu Glu His Pro Asn Pro Gly Lys Arg Tyr Pro
                645                 650                 655     
Gly Ile Gln Arg Thr Ala Tyr Leu Pro Asp Asn Lys Glu Gly Arg Lys
            660                 665                 670         
Val Leu Lys Leu Leu Tyr Arg Ala Phe Asp Gln Lys Leu Ile Phe Thr
        675                 680                 685             
Val Gly Tyr Ser Arg Val Leu Gly Val Ser Asp Val Ile Thr Trp Asn
    690                 695                 700                 
Asp Ile His His Lys Thr Ser Arg Phe Gly Gly Pro Glu Met Tyr Gly
705                 710                 715                 720 
Tyr Pro Asp Pro Ser Tyr Leu Lys Arg Val Lys Glu Glu Leu Lys Ala
                725                 730                 735     
Lys Gly Ile Glu
            740 


<210> 3003
<211> 281
<212> PRT
<213> Homo sapiens

<400> 3003
Met Ala Gly Thr Trp Leu Leu Leu Leu Leu Ala Leu Gly Cys Pro Ala
 1               5                  10                  15      
Leu Pro Thr Gly Val Gly Gly Thr Pro Phe Pro Ser Leu Ala Pro Pro
            20                  25                  30          
Ile Met Leu Leu Val Asp Gly Lys Gln Gln Met Val Val Val Cys Leu
        35                  40                  45              
Val Leu Asp Val Ala Pro Pro Gly Leu Asp Ser Pro Ile Trp Phe Ser
    50                  55                  60                  
Ala Gly Asn Gly Ser Ala Leu Asp Ala Phe Thr Tyr Gly Pro Ser Pro
65                  70                  75                  80  
Ala Thr Asp Gly Thr Trp Thr Asn Leu Ala His Leu Ser Leu Pro Ser
                85                  90                  95      
Glu Glu Leu Ala Ser Trp Glu Pro Leu Val Cys His Thr Gly Pro Gly
            100                 105                 110         
Ala Glu Gly His Ser Arg Ser Thr Gln Pro Met His Leu Ser Gly Glu
        115                 120                 125             
Ala Ser Thr Ala Arg Thr Cys Pro Gln Glu Pro Leu Arg Gly Thr Pro
    130                 135                 140                 
Gly Gly Ala Leu Trp Leu Gly Val Leu Arg Leu Leu Leu Phe Lys Leu
145                 150                 155                 160 
Leu Leu Phe Asp Leu Leu Leu Thr Cys Ser Cys Leu Cys Asp Pro Ala
                165                 170                 175     
Gly Pro Leu Pro Ser Pro Ala Thr Thr Thr Arg Leu Arg Ala Leu Gly
            180                 185                 190         
Ser His Arg Leu His Pro Ala Thr Glu Thr Gly Gly Arg Glu Ala Thr
        195                 200                 205             
Ser Ser Pro Arg Pro Gln Pro Arg Asp Arg Arg Trp Gly Asp Thr Pro
    210                 215                 220                 
Pro Gly Arg Lys Pro Gly Ser Pro Val Trp Gly Glu Gly Ser Tyr Leu
225                 230                 235                 240 
Ser Ser Tyr Pro Thr Cys Pro Ala Gln Ala Trp Cys Ser Arg Ser Arg
                245                 250                 255     
Leu Arg Ala Pro Ser Ser Ser Leu Gly Ala Phe Phe Arg Gly Asp Leu
            260                 265                 270         
Pro Pro Pro Leu Gln Ala Gly Ala Ala
        275                 280     


<210> 3004
<211> 990
<212> PRT
<213> Homo sapiens

<400> 3004
Met Ser Glu Glu Thr Arg Gln Ser Lys Leu Ala Ala Ala Lys Lys Lys
 1               5                  10                  15      
Leu Arg Glu Tyr Gln Gln Arg Asn Ser Pro Gly Val Pro Thr Gly Ala
            20                  25                  30          
Lys Lys Lys Lys Lys Ile Lys Asn Gly Ser Asn Pro Glu Thr Thr Thr
        35                  40                  45              
Ser Gly Gly Cys His Ser Pro Glu Asp Thr Pro Lys Asp Asn Ala Ala
    50                  55                  60                  
Thr Leu Gln Pro Ser Asp Asp Thr Val Leu Pro Gly Gly Val Pro Ser
65                  70                  75                  80  
Pro Gly Ala Ser Leu Thr Ser Met Ala Ala Ser Gln Asn His Asp Ala
                85                  90                  95      
Asp Asn Val Pro Asn Leu Met Asp Glu Thr Lys Thr Phe Ser Ser Thr
            100                 105                 110         
Glu Ser Leu Arg Gln Leu Ser Gln Gln Leu Asn Gly Leu Val Cys Glu
        115                 120                 125             
Ser Ala Thr Cys Val Asn Gly Glu Gly Pro Ala Ser Ser Ala Asn Leu
    130                 135                 140                 
Lys Asp Leu Glu Ser Arg Tyr Gln Gln Leu Ala Val Ala Leu Asp Ser
145                 150                 155                 160 
Ser Tyr Val Thr Asn Lys Gln Leu Asn Ile Thr Ile Glu Lys Leu Lys
                165                 170                 175     
Gln Gln Asn Gln Glu Ile Thr Asp Gln Leu Glu Glu Glu Lys Lys Glu
            180                 185                 190         
Cys His Gln Lys Gln Gly Ala Leu Arg Glu Gln Leu Gln Val His Ile
        195                 200                 205             
Gln Thr Ile Gly Ile Leu Val Ser Glu Lys Ala Glu Leu Gln Thr Ala
    210                 215                 220                 
Leu Ala His Thr Gln His Ala Ala Arg Gln Lys Glu Gly Glu Ser Glu
225                 230                 235                 240 
Asp Leu Ala Ser Arg Leu Gln Tyr Ser Arg Arg Arg Val Gly Glu Leu
                245                 250                 255     
Glu Arg Ala Leu Ser Ala Val Ser Thr Gln Gln Lys Lys Ala Asp Arg
            260                 265                 270         
Tyr Asn Lys Glu Leu Thr Lys Glu Arg Asp Ala Leu Arg Leu Glu Leu
        275                 280                 285             
Tyr Lys Asn Thr Gln Ser Asn Glu Asp Leu Lys Gln Glu Lys Ser Glu
    290                 295                 300                 
Leu Glu Glu Lys Leu Arg Val Leu Val Thr Glu Lys Ala Gly Met Gln
305                 310                 315                 320 
Leu Asn Leu Glu Glu Leu Gln Lys Lys Leu Glu Met Thr Glu Leu Leu
                325                 330                 335     
Leu Gln Gln Phe Ser Ser Arg Cys Glu Ala Pro Asp Ala Asn Gln Gln
            340                 345                 350         
Leu Gln Gln Ala Met Glu Glu Arg Ala Gln Leu Glu Ala His Leu Gly
        355                 360                 365             
Gln Val Met Glu Ser Val Arg Gln Leu Gln Met Glu Arg Asp Lys Tyr
    370                 375                 380                 
Ala Glu Asn Leu Lys Gly Glu Ser Ala Met Trp Arg Gln Arg Met Gln
385                 390                 395                 400 
Gln Met Ser Glu Gln Val His Thr Leu Arg Glu Glu Lys Glu Cys Ser
                405                 410                 415     
Met Ser Arg Val Gln Glu Leu Glu Thr Ser Leu Ala Glu Leu Arg Asn
            420                 425                 430         
Gln Met Ala Glu Pro Pro Pro Pro Glu Pro Pro Ala Gly Pro Ser Glu
        435                 440                 445             
Val Glu Gln Gln Leu Gln Ala Glu Ala Glu His Leu Arg Lys Glu Leu
    450                 455                 460                 
Glu Gly Leu Ala Gly Gln Leu Gln Ala Gln Val Gln Asp Asn Glu Gly
465                 470                 475                 480 
Leu Ser Arg Leu Asn Arg Glu Gln Glu Glu Arg Leu Leu Glu Leu Glu
                485                 490                 495     
Arg Ala Ala Glu Leu Trp Gly Glu Gln Ala Glu Ala Arg Arg Gln Ile
            500                 505                 510         
Leu Glu Thr Met Gln Asn Asp Arg Thr Thr Ile Ser Arg Ala Leu Ser
        515                 520                 525             
Gln Asn Arg Glu Leu Lys Glu Gln Leu Ala Glu Leu Gln Ser Gly Phe
    530                 535                 540                 
Val Lys Leu Thr Asn Glu Asn Met Glu Ile Thr Ser Ala Leu Gln Ser
545                 550                 555                 560 
Glu Gln His Val Lys Arg Glu Leu Gly Lys Lys Leu Gly Glu Leu Gln
                565                 570                 575     
Glu Lys Leu Ser Glu Leu Lys Glu Thr Val Glu Leu Lys Ser Gln Glu
            580                 585                 590         
Ala Gln Ser Leu Gln Gln Gln Arg Asp Gln Tyr Leu Gly His Leu Gln
        595                 600                 605             
Gln Tyr Val Ala Ala Tyr Gln Gln Leu Thr Ser Glu Lys Glu Val Leu
    610                 615                 620                 
His Asn Gln Leu Leu Leu Gln Thr Gln Leu Val Asp Gln Leu Gln Gln
625                 630                 635                 640 
Gln Glu Ala Gln Gly Lys Ala Val Ala Glu Met Ala Arg Gln Glu Leu
                645                 650                 655     
Gln Glu Thr Gln Glu Arg Leu Glu Ala Ala Thr Gln Gln Asn Gln Gln
            660                 665                 670         
Leu Arg Ala Gln Leu Ser Leu Met Ala His Pro Gly Glu Gly Asp Gly
        675                 680                 685             
Leu Asp Arg Glu Glu Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Ala
    690                 695                 700                 
Val Ala Val Pro Gln Pro Met Pro Ser Ile Pro Glu Asp Leu Glu Ser
705                 710                 715                 720 
Arg Glu Ala Met Val Ala Phe Phe Asn Ser Ala Val Ala Ser Ala Glu
                725                 730                 735     
Glu Glu Gln Ala Arg Leu Arg Gly Gln Leu Lys Glu Gln Arg Val Arg
            740                 745                 750         
Cys Arg Arg Leu Ala His Leu Leu Ala Ser Ala Gln Lys Glu Pro Glu
        755                 760                 765             
Ala Ala Ala Pro Ala Pro Gly Thr Gly Gly Asp Ser Val Cys Gly Glu
    770                 775                 780                 
Thr His Arg Ala Leu Gln Gly Ala Met Glu Lys Leu Gln Ser Arg Phe
785                 790                 795                 800 
Met Glu Leu Met Gln Glu Lys Ala Asp Leu Lys Glu Arg Val Glu Glu
                805                 810                 815     
Leu Glu His Arg Cys Ile Gln Leu Ser Gly Glu Thr Asp Thr Ile Gly
            820                 825                 830         
Glu Tyr Ile Ala Leu Tyr Gln Ser Gln Arg Ala Val Leu Lys Glu Arg
        835                 840                 845             
His Arg Glu Lys Glu Glu Tyr Ile Ser Arg Leu Ala Gln Asp Lys Glu
    850                 855                 860                 
Glu Met Lys Val Lys Leu Leu Glu Leu Gln Glu Leu Val Leu Arg Leu
865                 870                 875                 880 
Val Gly Asp Arg Asn Glu Trp His Gly Arg Phe Leu Ala Ala Ala Gln
                885                 890                 895     
Asn Pro Ala Asp Glu Pro Thr Ser Gly Ala Pro Ala Pro Gln Glu Leu
            900                 905                 910         
Gly Ala Ala Asn Gln Gln Gly Asp Leu Cys Glu Val Ser Leu Ala Gly
        915                 920                 925             
Ser Val Glu Pro Ala Gln Gly Glu Ala Arg Glu Gly Ser Pro Arg Asp
    930                 935                 940                 
Asn Pro Thr Ala Gln Gln Ile Met Gln Leu Leu Arg Glu Met Gln Asn
945                 950                 955                 960 
Pro Arg Glu Arg Pro Gly Leu Gly Ser Asn Pro Cys Ile Pro Phe Phe
                965                 970                 975     
Tyr Arg Ala Asp Glu Asn Asp Glu Val Lys Ile Thr Val Ile
            980                 985                 990 


<210> 3005
<211> 284
<212> PRT
<213> Homo sapiens

<400> 3005
Met Cys Asn Thr Pro Thr Tyr Cys Asp Leu Gly Lys Ala Ala Lys Asp
 1               5                  10                  15      
Val Phe Asn Lys Gly Tyr Gly Phe Gly Met Val Lys Ile Asp Leu Lys
            20                  25                  30          
Thr Lys Ser Cys Ser Gly Val Met Glu Phe Ser Thr Ser Gly His Ala
        35                  40                  45              
Tyr Thr Asp Thr Gly Lys Ala Ser Gly Asn Leu Glu Thr Lys Tyr Lys
    50                  55                  60                  
Val Cys Asn Tyr Gly Leu Thr Phe Thr Gln Lys Trp Asn Thr Asp Asn
65                  70                  75                  80  
Thr Leu Gly Thr Glu Ile Ser Trp Glu Asn Lys Leu Ala Glu Gly Leu
                85                  90                  95      
Lys Leu Thr Leu Asp Thr Ile Phe Val Pro Asn Thr Gly Lys Lys Ser
            100                 105                 110         
Gly Lys Leu Lys Ala Ser Tyr Lys Arg Asp Cys Phe Ser Val Gly Ser
        115                 120                 125             
Asn Val Asp Ile Asp Phe Ser Gly Pro Thr Ile Tyr Gly Trp Ala Val
    130                 135                 140                 
Leu Ala Phe Glu Gly Trp Leu Ala Gly Tyr Gln Met Ser Phe Asp Thr
145                 150                 155                 160 
Ala Lys Ser Lys Leu Ser Gln Asn Asn Phe Ala Leu Gly Tyr Lys Ala
                165                 170                 175     
Ala Asp Phe Gln Leu His Thr His Val Asn Asp Gly Thr Glu Phe Gly
            180                 185                 190         
Gly Ser Ile Tyr Gln Lys Val Asn Glu Lys Ile Glu Thr Ser Ile Asn
        195                 200                 205             
Leu Ala Trp Thr Ala Gly Ser Asn Asn Thr Arg Phe Gly Ile Ala Ala
    210                 215                 220                 
Lys Tyr Met Leu Asp Cys Arg Thr Ser Leu Ser Ala Lys Val Asn Asn
225                 230                 235                 240 
Ala Ser Leu Ile Gly Leu Gly Tyr Thr Gln Thr Leu Arg Pro Gly Val
                245                 250                 255     
Lys Leu Thr Leu Ser Ala Leu Ile Asp Gly Lys Asn Phe Ser Ala Gly
            260                 265                 270         
Gly His Lys Val Gly Leu Gly Phe Glu Leu Glu Ala
        275                 280                 


<210> 3006
<211> 318
<212> PRT
<213> Homo sapiens

<400> 3006
Met Val Glu Leu Met Phe Pro Leu Leu Leu Leu Leu Leu Pro Phe Leu
 1               5                  10                  15      
Leu Tyr Met Ala Ala Pro Gln Ile Arg Lys Met Leu Ser Ser Gly Val
            20                  25                  30          
Cys Thr Ser Thr Val Gln Leu Pro Gly Lys Val Val Val Val Thr Gly
        35                  40                  45              
Ala Asn Thr Gly Ile Gly Lys Glu Thr Ala Lys Glu Leu Ala Gln Arg
    50                  55                  60                  
Gly Ala Arg Val Tyr Leu Ala Cys Arg Asp Val Glu Lys Gly Glu Leu
65                  70                  75                  80  
Val Ala Lys Glu Ile Gln Thr Thr Thr Gly Asn Gln Gln Val Leu Val
                85                  90                  95      
Arg Lys Leu Asp Leu Ser Asp Thr Lys Ser Ile Arg Ala Phe Ala Lys
            100                 105                 110         
Gly Phe Leu Ala Glu Glu Lys His Leu His Val Leu Ile Asn Asn Ala
        115                 120                 125             
Gly Val Met Met Cys Pro Tyr Ser Lys Thr Ala Asp Gly Phe Glu Met
    130                 135                 140                 
His Ile Gly Val Asn His Leu Gly His Phe Leu Leu Thr His Leu Leu
145                 150                 155                 160 
Leu Glu Lys Leu Lys Glu Ser Ala Pro Ser Arg Ile Val Asn Val Ser
                165                 170                 175     
Ser Leu Ala His His Leu Gly Arg Ile His Phe His Asn Leu Gln Gly
            180                 185                 190         
Glu Lys Phe Tyr Asn Ala Gly Leu Ala Tyr Cys His Ser Lys Leu Ala
        195                 200                 205             
Asn Ile Leu Phe Thr Gln Glu Leu Ala Arg Arg Leu Lys Gly Ser Gly
    210                 215                 220                 
Val Thr Thr Tyr Ser Val His Pro Gly Thr Val Gln Ser Glu Leu Val
225                 230                 235                 240 
Arg His Ser Ser Phe Met Arg Trp Met Trp Trp Leu Phe Ser Phe Phe
                245                 250                 255     
Ile Lys Thr Pro Gln Gln Gly Ala Gln Thr Ser Leu His Cys Ala Leu
            260                 265                 270         
Thr Glu Gly Leu Glu Ile Leu Ser Gly Asn His Phe Ser Asp Cys His
        275                 280                 285             
Val Ala Trp Val Ser Ala Gln Ala Arg Asn Glu Thr Ile Ala Arg Arg
    290                 295                 300                 
Leu Trp Asp Val Ser Cys Asp Leu Leu Gly Leu Ser Ile Asp
305                 310                 315             


<210> 3007
<211> 763
<212> PRT
<213> Homo sapiens

<400> 3007
Met Val Ala Cys Arg Ala Ile Gly Ile Leu Ser Arg Phe Ser Ala Phe
 1               5                  10                  15      
Arg Ile Leu Arg Ser Arg Gly Tyr Ile Cys Arg Asn Phe Thr Gly Ser
            20                  25                  30          
Ser Ala Leu Leu Thr Arg Thr His Ile Asn Tyr Gly Val Lys Gly Asp
        35                  40                  45              
Val Ala Val Val Arg Ile Asn Ser Pro Asn Ser Lys Val Asn Thr Leu
    50                  55                  60                  
Ser Lys Glu Leu His Ser Glu Phe Ser Glu Val Met Asn Glu Ile Trp
65                  70                  75                  80  
Ala Ser Asp Gln Ile Arg Ser Ala Val Leu Ile Ser Ser Lys Pro Gly
                85                  90                  95      
Cys Phe Ile Ala Gly Ala Asp Ile Asn Met Leu Ala Ala Cys Lys Thr
            100                 105                 110         
Leu Gln Glu Val Thr Gln Leu Ser Gln Glu Ala Gln Arg Ile Val Glu
        115                 120                 125             
Lys Leu Glu Lys Ser Thr Lys Pro Ile Val Ala Ala Ile Asn Gly Ser
    130                 135                 140                 
Cys Leu Gly Gly Gly Leu Glu Val Ala Ile Ser Cys Gln Tyr Arg Ile
145                 150                 155                 160 
Ala Thr Lys Asp Arg Lys Thr Val Leu Gly Thr Pro Glu Val Leu Leu
                165                 170                 175     
Gly Ala Leu Pro Gly Ala Gly Gly Thr Gln Arg Leu Pro Lys Met Val
            180                 185                 190         
Gly Val Pro Ala Ala Leu Asp Met Met Leu Thr Gly Arg Ser Ile Arg
        195                 200                 205             
Ala Asp Arg Ala Lys Lys Met Gly Leu Val Asp Gln Leu Val Glu Pro
    210                 215                 220                 
Leu Gly Pro Gly Leu Lys Pro Pro Glu Glu Arg Thr Ile Glu Tyr Leu
225                 230                 235                 240 
Glu Glu Val Ala Ile Thr Phe Ala Lys Gly Leu Ala Asp Lys Lys Ile
                245                 250                 255     
Ser Pro Lys Arg Asp Lys Gly Leu Val Glu Lys Leu Thr Ala Tyr Ala
            260                 265                 270         
Met Thr Ile Pro Phe Val Arg Gln Gln Val Tyr Lys Lys Val Glu Glu
        275                 280                 285             
Lys Val Arg Lys Gln Thr Lys Gly Leu Tyr Pro Ala Pro Leu Lys Ile
    290                 295                 300                 
Ile Asp Val Val Lys Thr Gly Ile Glu Gln Gly Ser Asp Ala Gly Tyr
305                 310                 315                 320 
Leu Cys Glu Ser Gln Lys Phe Gly Glu Leu Val Met Thr Lys Glu Ser
                325                 330                 335     
Lys Ala Leu Met Gly Leu Tyr His Gly Gln Val Leu Cys Lys Lys Asn
            340                 345                 350         
Lys Phe Gly Ala Pro Gln Lys Asp Val Lys His Leu Ala Ile Leu Gly
        355                 360                 365             
Ala Gly Leu Met Gly Ala Gly Ile Ala Gln Val Ser Val Asp Lys Gly
    370                 375                 380                 
Leu Lys Thr Ile Leu Lys Asp Ala Thr Leu Thr Ala Leu Asp Arg Gly
385                 390                 395                 400 
Gln Gln Gln Val Phe Lys Gly Leu Asn Asp Lys Val Lys Lys Lys Ala
                405                 410                 415     
Leu Thr Ser Phe Glu Arg Asp Ser Ile Phe Ser Asn Leu Thr Gly Gln
            420                 425                 430         
Leu Asp Tyr Gln Gly Phe Glu Lys Ala Asp Met Val Ile Glu Ala Val
        435                 440                 445             
Phe Glu Asp Leu Ser Leu Lys His Arg Val Leu Lys Glu Val Glu Ala
    450                 455                 460                 
Val Ile Pro Asp His Cys Ile Phe Ala Ser Asn Thr Ser Ala Leu Pro
465                 470                 475                 480 
Ile Ser Glu Ile Ala Ala Val Ser Lys Arg Pro Glu Lys Val Ile Gly
                485                 490                 495     
Met His Tyr Phe Ser Pro Val Asp Lys Met Gln Leu Leu Glu Ile Ile
            500                 505                 510         
Thr Thr Glu Lys Thr Ser Lys Asp Thr Ser Ala Ser Ala Val Ala Val
        515                 520                 525             
Gly Leu Lys Gln Gly Lys Val Ile Ile Val Val Lys Asp Gly Pro Gly
    530                 535                 540                 
Phe Tyr Thr Thr Arg Cys Leu Ala Pro Met Met Ser Glu Val Ile Arg
545                 550                 555                 560 
Ile Leu Gln Glu Gly Val Asp Pro Lys Lys Leu Asp Ser Leu Thr Thr
                565                 570                 575     
Ser Phe Gly Phe Pro Val Gly Ala Ala Thr Leu Val Asp Glu Val Gly
            580                 585                 590         
Val Asp Val Ala Lys His Val Ala Glu Asp Leu Gly Lys Val Phe Gly
        595                 600                 605             
Glu Arg Phe Gly Gly Gly Asn Pro Glu Leu Leu Thr Gln Met Val Ser
    610                 615                 620                 
Lys Gly Phe Leu Gly Arg Lys Ser Gly Lys Gly Phe Tyr Ile Tyr Gln
625                 630                 635                 640 
Glu Gly Val Lys Arg Lys Asp Leu Asn Ser Asp Met Asp Ser Ile Leu
                645                 650                 655     
Ala Ser Leu Lys Leu Pro Pro Lys Ser Glu Val Ser Ser Asp Glu Asp
            660                 665                 670         
Ile Gln Phe Arg Leu Val Thr Arg Phe Val Asn Glu Ala Val Met Cys
        675                 680                 685             
Leu Gln Glu Gly Ile Leu Ala Thr Pro Ala Glu Gly Asp Ile Gly Ala
    690                 695                 700                 
Val Phe Gly Leu Gly Phe Pro Pro Cys Leu Gly Gly Pro Phe Arg Phe
705                 710                 715                 720 
Val Asp Leu Tyr Gly Ala Gln Lys Ile Val Asp Arg Leu Lys Lys Tyr
                725                 730                 735     
Glu Ala Ala Tyr Gly Lys Gln Phe Thr Pro Cys Gln Leu Leu Ala Asp
            740                 745                 750         
His Ala Asn Ser Pro Asn Lys Lys Phe Tyr Gln
        755                 760             


<210> 3008
<211> 505
<212> PRT
<213> Homo sapiens

<400> 3008
Met Arg Leu Arg Arg Leu Ala Leu Phe Pro Gly Val Ala Leu Leu Leu
 1               5                  10                  15      
Ala Ala Gly Arg Leu Val Ala Ala Ser Asp Val Leu Glu Leu Thr Asp
            20                  25                  30          
Asp Asn Phe Glu Ser Arg Ile Ser Asp Thr Gly Ser Ala Gly Leu Met
        35                  40                  45              
Leu Val Glu Phe Phe Ala Pro Trp Cys Gly His Cys Lys Arg Leu Ala
    50                  55                  60                  
Pro Glu Tyr Glu Ala Ala Ala Thr Arg Leu Lys Gly Ile Val Pro Leu
65                  70                  75                  80  
Ala Lys Val Asp Cys Thr Ala Asn Thr Asn Thr Cys Asn Lys Tyr Gly
                85                  90                  95      
Val Ser Gly Tyr Pro Thr Leu Lys Ile Phe Arg Asp Gly Glu Glu Ala
            100                 105                 110         
Gly Ala Tyr Asp Gly Pro Arg Thr Ala Asp Gly Ile Val Ser His Leu
        115                 120                 125             
Lys Lys Gln Ala Gly Pro Ala Ser Val Pro Leu Arg Thr Glu Glu Glu
    130                 135                 140                 
Phe Lys Lys Phe Ile Ser Asp Lys Asp Ala Ser Ile Val Gly Phe Phe
145                 150                 155                 160 
Asp Asp Ser Phe Ser Glu Ala His Ser Glu Phe Leu Lys Ala Ala Ser
                165                 170                 175     
Asn Leu Arg Asp Asn Tyr Arg Phe Ala His Thr Asn Val Glu Ser Leu
            180                 185                 190         
Val Asn Glu Tyr Asp Asp Asn Gly Glu Gly Ile Ile Leu Phe Arg Pro
        195                 200                 205             
Ser His Leu Thr Asn Lys Phe Glu Asp Lys Thr Val Ala Tyr Thr Glu
    210                 215                 220                 
Gln Lys Met Thr Ser Gly Lys Ile Lys Lys Phe Ile Gln Glu Asn Ile
225                 230                 235                 240 
Phe Gly Ile Cys Pro His Met Thr Glu Asp Asn Lys Asp Leu Ile Gln
                245                 250                 255     
Gly Lys Asp Leu Leu Ile Ala Tyr Tyr Asp Val Asp Tyr Glu Lys Asn
            260                 265                 270         
Ala Lys Gly Ser Asn Tyr Trp Arg Asn Arg Val Met Met Val Ala Lys
        275                 280                 285             
Lys Phe Leu Asp Ala Gly His Lys Leu Asn Phe Ala Val Ala Ser Arg
    290                 295                 300                 
Lys Thr Phe Ser His Glu Leu Ser Asp Phe Gly Leu Glu Ser Thr Ala
305                 310                 315                 320 
Gly Glu Ile Pro Val Val Ala Ile Arg Thr Ala Lys Gly Glu Lys Phe
                325                 330                 335     
Val Met Gln Glu Glu Phe Ser Arg Asp Gly Lys Ala Leu Glu Arg Phe
            340                 345                 350         
Leu Gln Asp Tyr Phe Asp Gly Asn Leu Lys Arg Tyr Leu Lys Ser Glu
        355                 360                 365             
Pro Ile Pro Glu Ser Asn Asp Gly Pro Val Lys Val Val Val Ala Glu
    370                 375                 380                 
Asn Phe Asp Glu Ile Val Asn Asn Glu Asn Lys Asp Val Leu Ile Glu
385                 390                 395                 400 
Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Asn Leu Glu Pro Lys Tyr
                405                 410                 415     
Lys Glu Leu Gly Glu Lys Leu Ser Lys Asp Pro Asn Ile Val Ile Ala
            420                 425                 430         
Lys Met Asp Ala Thr Ala Asn Asp Val Pro Ser Pro Tyr Glu Val Arg
        435                 440                 445             
Gly Phe Pro Thr Ile Tyr Phe Ser Pro Ala Asn Lys Lys Leu Asn Pro
    450                 455                 460                 
Lys Lys Tyr Glu Gly Gly Arg Glu Leu Ser Asp Phe Ile Ser Tyr Leu
465                 470                 475                 480 
Gln Arg Glu Ala Thr Asn Pro Pro Val Ile Gln Glu Glu Lys Pro Lys
                485                 490                 495     
Lys Lys Lys Lys Ala Gln Glu Asp Leu
            500                 505 


<210> 3009
<211> 483
<212> PRT
<213> Homo sapiens

<400> 3009
Met Ser Asn Lys Leu Leu Ser Pro His Pro His Ser Val Val Leu Arg
 1               5                  10                  15      
Ser Glu Phe Lys Met Ala Ser Ser Pro Ala Val Leu Arg Ala Ser Arg
            20                  25                  30          
Leu Tyr Gln Trp Ser Leu Lys Ser Ser Ala Gln Phe Leu Gly Ser Pro
        35                  40                  45              
Gln Leu Arg Gln Val Gly Gln Ile Ile Arg Val Pro Ala Arg Met Ala
    50                  55                  60                  
Ala Thr Leu Ile Leu Glu Pro Ala Gly Arg Cys Cys Trp Asp Glu Pro
65                  70                  75                  80  
Val Arg Ile Ala Val Arg Gly Leu Ala Pro Glu Gln Pro Val Thr Leu
                85                  90                  95      
Arg Ala Ser Leu Arg Asp Glu Lys Gly Ala Leu Phe Gln Ala His Ala
            100                 105                 110         
Arg Tyr Arg Ala Asp Thr Leu Gly Glu Leu Asp Leu Glu Arg Ala Pro
        115                 120                 125             
Ala Leu Gly Gly Ser Phe Ala Gly Leu Glu Pro Met Gly Leu Leu Trp
    130                 135                 140                 
Ala Leu Glu Pro Glu Lys Pro Leu Val Arg Leu Val Lys Arg Asp Val
145                 150                 155                 160 
Arg Thr Pro Leu Ala Val Glu Leu Glu Val Leu Asp Gly His Asp Pro
                165                 170                 175     
Asp Pro Gly Arg Leu Leu Cys Gln Thr Arg His Glu Arg Tyr Phe Leu
            180                 185                 190         
Pro Pro Gly Val Arg Arg Glu Pro Val Arg Val Gly Arg Val Arg Gly
        195                 200                 205             
Thr Leu Phe Leu Pro Pro Glu Pro Gly Pro Phe Pro Gly Ile Val Asp
    210                 215                 220                 
Met Phe Gly Thr Gly Gly Gly Leu Leu Glu Tyr Arg Ala Ser Leu Leu
225                 230                 235                 240 
Ala Gly Lys Gly Phe Ala Val Met Ala Leu Ala Tyr Tyr Asn Tyr Glu
                245                 250                 255     
Asp Leu Pro Lys Thr Met Glu Thr Leu His Leu Glu Tyr Phe Glu Glu
            260                 265                 270         
Ala Met Asn Tyr Leu Leu Ser His Pro Glu Val Lys Gly Pro Gly Val
        275                 280                 285             
Gly Leu Leu Gly Ile Ser Lys Gly Gly Glu Leu Cys Leu Ser Met Ala
    290                 295                 300                 
Ser Phe Leu Lys Gly Ile Thr Ala Ala Val Val Ile Asn Gly Ser Val
305                 310                 315                 320 
Ala Asn Val Gly Gly Thr Leu Arg Tyr Lys Gly Glu Thr Leu Pro Pro
                325                 330                 335     
Val Gly Val Asn Arg Asn Arg Ile Lys Val Thr Lys Asp Gly Tyr Ala
            340                 345                 350         
Asp Ile Val Asp Val Leu Asn Ser Pro Leu Glu Gly Pro Asp Gln Lys
        355                 360                 365             
Ser Phe Ile Pro Val Glu Arg Ala Glu Ser Thr Phe Leu Phe Leu Val
    370                 375                 380                 
Gly Gln Asp Asp His Asn Trp Lys Ser Glu Phe Tyr Ala Asn Glu Ala
385                 390                 395                 400 
Cys Lys Arg Leu Gln Ala His Gly Arg Arg Lys Pro Gln Ile Ile Cys
                405                 410                 415     
Tyr Pro Glu Thr Gly His Tyr Ile Glu Pro Pro Tyr Phe Pro Leu Cys
            420                 425                 430         
Arg Ala Ser Leu His Ala Leu Val Gly Ser Pro Ile Ile Trp Gly Gly
        435                 440                 445             
Glu Pro Arg Ala His Val Met Ala Gln Val Asp Ala Trp Lys Gln Leu
    450                 455                 460                 
Gln Thr Phe Phe His Lys His Leu Gly Gly His Glu Gly Thr Ile Pro
465                 470                 475                 480 
Ser Lys Val
            


<210> 3010
<211> 396
<212> PRT
<213> Homo sapiens

<400> 3010
Met Ala Ala Pro Cys Val Ser Tyr Gly Gly Ala Val Ser Tyr Arg Leu
 1               5                  10                  15      
Leu Leu Trp Gly Arg Gly Ser Leu Ala Arg Lys Gln Gly Leu Trp Lys
            20                  25                  30          
Thr Ala Ala Pro Glu Leu Gln Thr Asn Val Arg Ser Gln Ile Leu Arg
        35                  40                  45              
Leu Arg His Thr Ala Phe Val Ile Pro Lys Lys Asn Val Pro Thr Ser
    50                  55                  60                  
Lys Arg Glu Thr Tyr Thr Glu Asp Phe Ile Lys Lys Gln Ile Glu Glu
65                  70                  75                  80  
Phe Asn Ile Gly Lys Arg His Leu Ala Asn Met Met Gly Glu Asp Pro
                85                  90                  95      
Glu Thr Phe Thr Gln Glu Asp Ile Asp Arg Ala Ile Ala Tyr Leu Phe
            100                 105                 110         
Pro Ser Gly Leu Phe Glu Lys Arg Ala Arg Pro Val Met Lys His Pro
        115                 120                 125             
Glu Gln Ile Phe Pro Arg Gln Arg Ala Ile Gln Trp Gly Glu Asp Gly
    130                 135                 140                 
Arg Pro Phe His Tyr Leu Phe Tyr Thr Gly Lys Gln Ser Tyr Tyr Ser
145                 150                 155                 160 
Leu Met His Asp Val Tyr Gly Met Leu Leu Thr Leu Glu Lys His Gln
                165                 170                 175     
Ser His Trp Gln Ala Lys Ser Leu Leu Pro Glu Lys Thr Val Thr Arg
            180                 185                 190         
Asp Val Ile Gly Ser Arg Trp Leu Ile Lys Glu Glu Leu Glu Glu Met
        195                 200                 205             
Leu Val Gly Lys Leu Ser Asp Leu Asp Tyr Met Gln Phe Ile Arg Leu
    210                 215                 220                 
Leu Glu Lys Leu Leu Thr Ser Gln Cys Gly Ala Ala Glu Glu Glu Phe
225                 230                 235                 240 
Val Gln Arg Phe Arg Arg Ser Val Thr Leu Glu Ser Lys Lys Gln Leu
                245                 250                 255     
Ile Glu Pro Val Gln Tyr Asp Glu Gln Gly Met Ala Phe Ser Lys Ser
            260                 265                 270         
Glu Gly Lys Arg Lys Thr Ala Lys Ala Glu Ala Ile Val Tyr Lys His
        275                 280                 285             
Gly Ser Gly Arg Ile Lys Val Asn Gly Ile Asp Tyr Gln Leu Tyr Phe
    290                 295                 300                 
Pro Ile Thr Gln Asp Arg Glu Gln Leu Met Phe Pro Phe His Phe Val
305                 310                 315                 320 
Asp Arg Leu Gly Lys His Asp Val Thr Cys Thr Val Ser Gly Gly Gly
                325                 330                 335     
Arg Ser Ala Gln Ala Gly Ala Ile Arg Leu Ala Met Ala Lys Ala Leu
            340                 345                 350         
Cys Ser Phe Val Thr Glu Asp Glu Val Glu Trp Met Arg Gln Ala Gly
        355                 360                 365             
Leu Leu Thr Thr Asp Pro Arg Val Arg Glu Arg Lys Lys Pro Gly Gln
    370                 375                 380                 
Glu Gly Ala Arg Arg Lys Phe Thr Trp Lys Lys Arg
385                 390                 395     


<210> 3011
<211> 322
<212> PRT
<213> Homo sapiens

<400> 3011
Met Ser Gly Glu Leu Pro Pro Asn Ile Asn Ile Lys Glu Pro Arg Trp
 1               5                  10                  15      
Asp Gln Ser Thr Phe Ile Gly Arg Ala Asn His Phe Phe Thr Val Thr
            20                  25                  30          
Asp Pro Arg Asn Ile Leu Leu Thr Asn Glu Gln Leu Glu Ser Ala Arg
        35                  40                  45              
Lys Ile Val His Asp Tyr Arg Gln Gly Ile Val Pro Pro Gly Leu Thr
    50                  55                  60                  
Glu Asn Glu Leu Trp Arg Ala Lys Tyr Ile Tyr Asp Ser Ala Phe His
65                  70                  75                  80  
Pro Asp Thr Gly Glu Lys Met Ile Leu Ile Gly Arg Met Ser Ala Gln
                85                  90                  95      
Val Pro Met Asn Met Thr Ile Thr Gly Cys Met Met Thr Phe Tyr Arg
            100                 105                 110         
Thr Thr Pro Ala Val Leu Phe Trp Gln Trp Ile Asn Gln Ser Phe Asn
        115                 120                 125             
Ala Val Val Asn Tyr Thr Asn Arg Ser Gly Asp Ala Pro Leu Thr Val
    130                 135                 140                 
Asn Glu Leu Gly Thr Ala Tyr Val Ser Ala Thr Thr Gly Ala Val Ala
145                 150                 155                 160 
Thr Ala Leu Gly Leu Asn Ala Leu Thr Lys His Val Ser Pro Leu Ile
                165                 170                 175     
Gly Arg Phe Val Pro Phe Ala Ala Val Ala Ala Ala Asn Cys Ile Asn
            180                 185                 190         
Ile Pro Leu Met Arg Gln Arg Glu Leu Lys Val Gly Ile Pro Val Thr
        195                 200                 205             
Asp Glu Asn Gly Asn Arg Leu Gly Glu Ser Ala Asn Ala Ala Lys Gln
    210                 215                 220                 
Ala Ile Thr Gln Val Val Val Ser Arg Ile Leu Met Ala Ala Pro Gly
225                 230                 235                 240 
Met Ala Ile Pro Pro Phe Ile Met Asn Thr Leu Glu Lys Lys Ala Phe
                245                 250                 255     
Leu Lys Arg Phe Pro Trp Met Ser Ala Pro Ile Gln Val Gly Leu Val
            260                 265                 270         
Gly Phe Cys Leu Val Phe Ala Thr Pro Leu Cys Cys Ala Leu Phe Pro
        275                 280                 285             
Gln Lys Ser Ser Met Ser Val Thr Ser Leu Glu Ala Glu Leu Gln Ala
    290                 295                 300                 
Lys Ile Gln Glu Ser His Pro Glu Leu Arg Arg Val Tyr Phe Asn Lys
305                 310                 315                 320 
Gly Leu
        


<210> 3012
<211> 314
<212> PRT
<213> Homo sapiens

<400> 3012
Met Ala Phe Val Thr Arg Gln Phe Met Arg Ser Val Ser Ser Ser Ser
 1               5                  10                  15      
Thr Ala Ser Ala Ser Ala Lys Lys Ile Ile Val Lys His Val Thr Val
            20                  25                  30          
Ile Gly Gly Gly Leu Met Gly Ala Gly Ile Ala Gln Val Ala Ala Ala
        35                  40                  45              
Thr Gly His Thr Val Val Leu Val Asp Gln Thr Glu Asp Ile Leu Ala
    50                  55                  60                  
Lys Ser Lys Lys Gly Ile Glu Glu Ser Leu Arg Lys Val Ala Lys Lys
65                  70                  75                  80  
Lys Phe Ala Glu Asn Pro Lys Ala Gly Asp Glu Phe Val Glu Lys Thr
                85                  90                  95      
Leu Ser Thr Ile Ala Thr Ser Thr Asp Ala Ala Ser Val Val His Ser
            100                 105                 110         
Thr Asp Leu Val Val Glu Ala Ile Val Glu Asn Leu Lys Val Lys Asn
        115                 120                 125             
Glu Leu Phe Lys Arg Leu Asp Lys Phe Ala Ala Glu His Thr Ile Phe
    130                 135                 140                 
Ala Ser Asn Thr Ser Ser Leu Gln Ile Thr Ser Ile Ala Asn Ala Thr
145                 150                 155                 160 
Thr Arg Gln Asp Arg Phe Ala Gly Leu His Phe Phe Asn Pro Val Pro
                165                 170                 175     
Val Met Lys Leu Val Glu Val Ile Lys Thr Pro Met Thr Ser Gln Lys
            180                 185                 190         
Thr Phe Glu Ser Leu Val Asp Phe Ser Lys Ala Leu Gly Lys His Pro
        195                 200                 205             
Val Ser Cys Lys Asp Thr Pro Gly Phe Ile Val Asn Arg Leu Leu Val
    210                 215                 220                 
Pro Tyr Leu Met Glu Ala Ile Arg Leu Tyr Glu Arg Gly Asp Ala Ser
225                 230                 235                 240 
Lys Glu Asp Ile Asp Thr Ala Met Lys Leu Gly Ala Gly Tyr Pro Met
                245                 250                 255     
Gly Pro Phe Glu Leu Leu Asp Tyr Val Gly Leu Asp Thr Thr Lys Phe
            260                 265                 270         
Ile Val Asp Gly Trp His Glu Met Asp Ala Glu Asn Pro Leu His Gln
        275                 280                 285             
Pro Ser Pro Ser Leu Asn Lys Leu Val Ala Glu Asn Lys Phe Gly Lys
    290                 295                 300                 
Lys Thr Gly Glu Gly Phe Tyr Lys Tyr Lys
305                 310                 


<210> 3013
<211> 282
<212> PRT
<213> Homo sapiens

<400> 3013
Met Gly Glu His Asn Leu Leu Asn Pro Gly Phe Val Gly Pro Leu Val
 1               5                  10                  15      
Asn Ile His Thr Gly Asp Thr Phe Tyr Phe Pro Asn Phe Arg Ala Ser
            20                  25                  30          
Gly Ala Gln Leu Pro Gly Leu Pro Ser Leu Ser Tyr Pro Arg Arg Asp
        35                  40                  45              
Asn Val Cys Ser Leu Ser Trp Pro Ser Ala Glu Pro Cys Asn Gly Tyr
    50                  55                  60                  
Pro Gln Pro Tyr Leu Gly Ser Pro Val Ser Leu Asn Pro Pro Phe Gly
65                  70                  75                  80  
Arg Thr Cys Glu Leu Ala Arg Val Glu Asp Gly Lys Gly Tyr Tyr Arg
                85                  90                  95      
Glu Pro Cys Ala Glu Gly Gly Gly Gly Gly Leu Lys Arg Glu Glu Arg
            100                 105                 110         
Gly Arg Asp Pro Gly Ala Gly Pro Gly Ala Ala Leu Leu Pro Leu Glu
        115                 120                 125             
Pro Ser Gly Pro Pro Ala Leu Gly Phe Lys Tyr Asp Tyr Ala Ala Gly
    130                 135                 140                 
Gly Gly Gly Gly Asp Gly Gly Gly Gly Ala Gly Pro Pro His Asp Pro
145                 150                 155                 160 
Pro Ser Cys Gln Ser Leu Glu Ser Asp Ser Ser Ser Ser Leu Leu Asn
                165                 170                 175     
Glu Gly Asn Lys Gly Ala Gly Ala Gly Asp Pro Gly Ser Leu Val Ser
            180                 185                 190         
Pro Leu Asn Pro Gly Gly Gly Leu Ser Ala Ser Gly Ala Pro Trp Tyr
        195                 200                 205             
Pro Ile Asn Ser Arg Ser Arg Lys Lys Arg Lys Pro Tyr Ser Lys Leu
    210                 215                 220                 
Gln Leu Ala Glu Leu Glu Gly Glu Phe Leu Val Asn Glu Phe Ile Thr
225                 230                 235                 240 
Arg Gln Arg Arg Arg Glu Leu Ser Asp Arg Leu Asn Leu Ser Asp Gln
                245                 250                 255     
Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Lys Lys Arg Leu
            260                 265                 270         
Leu Leu Arg Glu Gln Ala Leu Ser Phe Phe
        275                 280         


<210> 3014
<211> 452
<212> PRT
<213> Homo sapiens

<400> 3014
Met Ala Gly Tyr Leu Arg Val Val Arg Ser Leu Cys Arg Ala Ser Gly
 1               5                  10                  15      
Ser Arg Pro Ala Trp Ala Pro Ala Ala Leu Thr Ala Pro Thr Ser Gln
            20                  25                  30          
Glu Gln Pro Arg Arg His Tyr Ala Asp Lys Arg Ile Lys Val Ala Lys
        35                  40                  45              
Pro Val Val Glu Met Asp Gly Asp Glu Met Thr Arg Ile Ile Trp Gln
    50                  55                  60                  
Phe Ile Lys Glu Lys Leu Ile Leu Pro His Val Asp Ile Gln Leu Lys
65                  70                  75                  80  
Tyr Phe Asp Leu Gly Leu Pro Asn Arg Asp Gln Thr Asp Asp Gln Val
                85                  90                  95      
Thr Ile Asp Ser Ala Leu Ala Thr Gln Lys Tyr Ser Val Ala Val Lys
            100                 105                 110         
Cys Ala Thr Ile Thr Pro Asp Glu Ala Arg Val Glu Glu Phe Lys Leu
        115                 120                 125             
Lys Lys Met Trp Lys Ser Pro Asn Gly Thr Ile Arg Asn Ile Leu Gly
    130                 135                 140                 
Gly Thr Val Phe Arg Glu Pro Ile Ile Cys Lys Asn Ile Pro Arg Leu
145                 150                 155                 160 
Val Pro Gly Trp Thr Lys Pro Ile Thr Ile Gly Arg His Ala His Gly
                165                 170                 175     
Asp Gln Tyr Lys Ala Thr Asp Phe Val Ala Asp Arg Ala Gly Thr Phe
            180                 185                 190         
Lys Met Val Phe Thr Pro Lys Asp Gly Ser Gly Val Lys Glu Trp Glu
        195                 200                 205             
Val Tyr Asn Phe Pro Ala Gly Gly Val Gly Met Gly Met Tyr Asn Thr
    210                 215                 220                 
Asp Glu Ser Ile Ser Gly Phe Ala His Ser Cys Phe Gln Tyr Ala Ile
225                 230                 235                 240 
Gln Lys Lys Trp Pro Leu Tyr Met Ser Thr Lys Asn Thr Ile Leu Lys
                245                 250                 255     
Ala Tyr Asp Gly Arg Phe Lys Asp Ile Phe Gln Glu Ile Phe Asp Lys
            260                 265                 270         
His Tyr Lys Thr Asp Phe Asp Lys Asn Lys Ile Trp Tyr Glu His Arg
        275                 280                 285             
Leu Ile Asp Asp Met Val Ala Gln Val Leu Lys Ser Ser Gly Gly Phe
    290                 295                 300                 
Val Trp Ala Cys Lys Asn Tyr Asp Gly Asp Val Gln Ser Asp Ile Leu
305                 310                 315                 320 
Ala Gln Gly Phe Gly Ser Leu Gly Leu Met Thr Ser Val Leu Val Cys
                325                 330                 335     
Pro Asp Gly Lys Thr Ile Glu Ala Glu Ala Ala His Gly Thr Val Thr
            340                 345                 350         
Arg His Tyr Arg Glu His Gln Lys Gly Arg Pro Thr Ser Thr Asn Pro
        355                 360                 365             
Ile Ala Ser Ile Phe Ala Trp Thr Arg Gly Leu Glu His Arg Gly Lys
    370                 375                 380                 
Leu Asp Gly Asn Gln Asp Leu Ile Arg Phe Ala Gln Met Leu Glu Lys
385                 390                 395                 400 
Val Cys Val Glu Thr Val Glu Ser Gly Ala Met Thr Lys Asp Leu Ala
                405                 410                 415     
Gly Cys Ile His Gly Leu Ser Asn Val Lys Leu Asn Glu His Phe Leu
            420                 425                 430         
Asn Thr Thr Asp Phe Leu Asp Thr Ile Lys Ser Asn Leu Asp Arg Ala
        435                 440                 445             
Leu Gly Arg Gln
    450         


<210> 3015
<211> 314
<212> PRT
<213> Homo sapiens

<400> 3015
Met Ala Ala Thr Ala Ser Ala Gly Ala Gly Gly Ile Asp Gly Lys Pro
 1               5                  10                  15      
Arg Thr Ser Pro Lys Ser Val Lys Phe Leu Phe Gly Gly Leu Ala Gly
            20                  25                  30          
Met Gly Ala Thr Val Phe Val Gln Pro Leu Asp Leu Val Lys Asn Arg
        35                  40                  45              
Met Gln Leu Ser Gly Glu Gly Ala Lys Thr Arg Glu Tyr Lys Thr Ser
    50                  55                  60                  
Phe His Ala Leu Thr Ser Ile Leu Lys Ala Glu Gly Leu Arg Gly Ile
65                  70                  75                  80  
Tyr Thr Gly Leu Ser Ala Gly Leu Leu Arg Gln Ala Thr Tyr Thr Thr
                85                  90                  95      
Thr Arg Leu Gly Ile Tyr Thr Val Leu Phe Glu Arg Leu Thr Gly Ala
            100                 105                 110         
Asp Gly Thr Pro Pro Gly Phe Leu Leu Lys Ala Val Ile Gly Met Thr
        115                 120                 125             
Ala Gly Ala Thr Gly Ala Phe Val Gly Thr Pro Ala Glu Val Ala Leu
    130                 135                 140                 
Ile Arg Met Thr Ala Asp Gly Arg Leu Pro Ala Asp Gln Arg Arg Gly
145                 150                 155                 160 
Tyr Lys Asn Val Phe Asn Ala Leu Ile Arg Ile Thr Arg Glu Glu Gly
                165                 170                 175     
Val Leu Thr Leu Trp Arg Gly Cys Ile Pro Thr Met Ala Arg Ala Val
            180                 185                 190         
Val Val Asn Ala Ala Gln Leu Ala Ser Tyr Ser Gln Ser Lys Gln Phe
        195                 200                 205             
Leu Leu Asp Ser Gly Tyr Phe Ser Asp Asn Ile Leu Cys His Phe Cys
    210                 215                 220                 
Ala Ser Met Ile Ser Gly Leu Val Thr Thr Ala Ala Ser Met Pro Val
225                 230                 235                 240 
Asp Ile Ala Lys Thr Arg Ile Gln Asn Met Arg Met Ile Asp Gly Lys
                245                 250                 255     
Pro Glu Tyr Lys Asn Gly Leu Asp Val Leu Phe Lys Val Val Arg Tyr
            260                 265                 270         
Glu Gly Phe Phe Ser Leu Trp Lys Gly Phe Thr Pro Tyr Tyr Ala Arg
        275                 280                 285             
Leu Gly Pro His Thr Val Leu Thr Phe Ile Phe Leu Glu Gln Met Asn
    290                 295                 300                 
Lys Ala Tyr Lys Arg Leu Phe Leu Ser Gly
305                 310                 


<210> 3016
<211> 333
<212> PRT
<213> Homo sapiens

<400> 3016
Met Val Ser Gly Ser Ser Gly Leu Ala Ala Ala Arg Leu Leu Ser Arg
 1               5                  10                  15      
Ser Phe Leu Leu Pro Gln Asn Gly Ile Arg His Cys Ser Tyr Thr Ala
            20                  25                  30          
Ser Arg Gln His Leu Tyr Val Asp Lys Asn Thr Lys Ile Ile Cys Gln
        35                  40                  45              
Gly Phe Thr Gly Lys Gln Gly Thr Phe His Ser Gln Gln Ala Leu Glu
    50                  55                  60                  
Tyr Gly Thr Lys Leu Val Gly Gly Thr Thr Pro Gly Lys Gly Gly Gln
65                  70                  75                  80  
Thr His Leu Gly Leu Pro Val Phe Asn Thr Val Lys Glu Ala Lys Glu
                85                  90                  95      
Gln Thr Gly Ala Thr Ala Ser Val Ile Tyr Val Pro Pro Pro Phe Ala
            100                 105                 110         
Ala Ala Ala Ile Asn Glu Ala Ile Glu Ala Glu Ile Pro Leu Val Val
        115                 120                 125             
Cys Ile Thr Glu Gly Ile Pro Gln Gln Asp Met Val Arg Val Lys His
    130                 135                 140                 
Lys Leu Leu Arg Gln Glu Lys Thr Arg Leu Ile Gly Pro Asn Cys Pro
145                 150                 155                 160 
Gly Val Ile Asn Pro Gly Glu Cys Lys Ile Gly Ile Met Pro Gly His
                165                 170                 175     
Ile His Lys Lys Gly Arg Ile Gly Ile Val Ser Arg Ser Gly Thr Leu
            180                 185                 190         
Thr Tyr Glu Ala Val His Gln Thr Thr Gln Val Gly Leu Gly Gln Ser
        195                 200                 205             
Leu Cys Val Gly Ile Gly Gly Asp Pro Phe Asn Gly Thr Asp Phe Ile
    210                 215                 220                 
Asp Cys Leu Glu Ile Phe Leu Asn Asp Ser Ala Thr Glu Gly Ile Ile
225                 230                 235                 240 
Leu Ile Gly Glu Ile Gly Gly Asn Ala Glu Glu Asn Ala Ala Glu Phe
                245                 250                 255     
Leu Lys Gln His Asn Ser Gly Pro Asn Ser Lys Pro Val Val Ser Phe
            260                 265                 270         
Ile Ala Gly Leu Thr Ala Pro Pro Gly Arg Arg Met Gly His Ala Gly
        275                 280                 285             
Ala Ile Ile Ala Gly Gly Lys Gly Gly Ala Lys Glu Lys Ile Ser Ala
    290                 295                 300                 
Leu Gln Ser Ala Gly Val Val Val Ser Met Ser Pro Ala Gln Leu Gly
305                 310                 315                 320 
Thr Thr Ile Tyr Lys Glu Phe Glu Lys Arg Lys Met Leu
                325                 330             


<210> 3017
<211> 1626
<212> PRT
<213> Homo sapiens

<400> 3017
Met Ala Lys Ser Gly Gly Cys Gly Ala Gly Ala Gly Val Gly Gly Gly
 1               5                  10                  15      
Asn Gly Ala Leu Thr Trp Val Thr Leu Phe Asp Gln Asn Asn Ala Ala
            20                  25                  30          
Lys Lys Glu Glu Ser Glu Thr Ala Asn Lys Asn Asp Ser Ser Lys Lys
        35                  40                  45              
Leu Ser Val Glu Arg Val Tyr Gln Lys Lys Thr Gln Leu Glu His Ile
    50                  55                  60                  
Leu Leu Arg Pro Asp Thr Tyr Ile Gly Ser Val Glu Pro Leu Thr Gln
65                  70                  75                  80  
Phe Met Trp Val Tyr Asp Glu Asp Val Gly Met Asn Cys Arg Glu Val
                85                  90                  95      
Thr Phe Val Pro Gly Leu Tyr Lys Ile Phe Asp Glu Ile Leu Val Asn
            100                 105                 110         
Ala Ala Asp Asn Lys Gln Arg Asp Lys Asn Met Thr Cys Ile Lys Val
        115                 120                 125             
Ser Ile Asp Pro Glu Ser Asn Ile Ile Ser Ile Trp Asn Asn Gly Lys
    130                 135                 140                 
Gly Ile Pro Val Val Glu His Lys Val Glu Lys Val Tyr Val Pro Ala
145                 150                 155                 160 
Leu Ile Phe Gly Gln Leu Leu Thr Ser Ser Asn Tyr Asp Asp Asp Glu
                165                 170                 175     
Lys Lys Val Thr Gly Gly Arg Asn Gly Tyr Gly Ala Lys Leu Cys Asn
            180                 185                 190         
Ile Phe Ser Thr Lys Phe Thr Val Glu Thr Ala Cys Lys Glu Tyr Lys
        195                 200                 205             
His Ser Phe Lys Gln Thr Trp Met Asn Asn Met Met Lys Thr Ser Glu
    210                 215                 220                 
Ala Lys Ile Lys His Phe Asp Gly Glu Asp Tyr Thr Cys Ile Thr Phe
225                 230                 235                 240 
Gln Pro Asp Leu Ser Lys Phe Lys Met Glu Lys Leu Asp Lys Asp Ile
                245                 250                 255     
Val Ala Leu Met Thr Arg Arg Ala Tyr Asp Leu Ala Gly Ser Cys Arg
            260                 265                 270         
Gly Val Lys Val Met Phe Asn Gly Lys Lys Leu Pro Val Asn Gly Phe
        275                 280                 285             
Arg Ser Tyr Val Asp Leu Tyr Val Lys Asp Lys Leu Asp Glu Thr Gly
    290                 295                 300                 
Val Ala Leu Lys Val Ile His Glu Leu Ala Asn Glu Arg Trp Asp Val
305                 310                 315                 320 
Cys Leu Thr Leu Ser Glu Lys Gly Phe Gln Gln Ile Ser Phe Val Asn
                325                 330                 335     
Ser Ile Ala Thr Thr Lys Gly Gly Arg His Val Asp Tyr Val Val Asp
            340                 345                 350         
Gln Val Val Gly Lys Leu Ile Glu Val Val Lys Lys Lys Asn Lys Ala
        355                 360                 365             
Gly Val Ser Val Lys Pro Phe Gln Val Lys Asn His Ile Trp Val Phe
    370                 375                 380                 
Ile Asn Cys Leu Ile Glu Asn Pro Thr Phe Asp Ser Gln Thr Lys Glu
385                 390                 395                 400 
Asn Met Thr Leu Gln Pro Lys Ser Phe Gly Ser Lys Cys Gln Leu Ser
                405                 410                 415     
Glu Lys Phe Phe Lys Ala Ala Ser Asn Cys Gly Ile Val Glu Ser Ile
            420                 425                 430         
Leu Asn Trp Val Lys Phe Lys Ala Gln Thr Gln Leu Asn Lys Lys Cys
        435                 440                 445             
Ser Ser Val Lys Tyr Ser Lys Ile Lys Gly Ile Pro Lys Leu Asp Asp
    450                 455                 460                 
Ala Asn Asp Ala Gly Gly Lys His Ser Leu Glu Cys Thr Leu Ile Leu
465                 470                 475                 480 
Thr Glu Gly Asp Ser Ala Lys Ser Leu Ala Val Ser Gly Leu Gly Val
                485                 490                 495     
Ile Gly Arg Asp Arg Tyr Gly Val Phe Pro Leu Arg Gly Lys Ile Leu
            500                 505                 510         
Asn Val Arg Glu Ala Ser His Lys Gln Ile Met Glu Asn Ala Glu Ile
        515                 520                 525             
Asn Asn Ile Ile Lys Ile Val Gly Leu Gln Tyr Lys Lys Ser Tyr Asp
    530                 535                 540                 
Asp Ala Glu Ser Leu Lys Thr Leu Arg Tyr Gly Lys Ile Met Ile Met
545                 550                 555                 560 
Thr Asp Gln Asp Gln Asp Gly Ser His Ile Lys Gly Leu Leu Ile Asn
                565                 570                 575     
Phe Ile His His Asn Trp Pro Ser Leu Leu Lys His Gly Phe Leu Glu
            580                 585                 590         
Glu Phe Ile Thr Pro Ile Val Lys Ala Ser Lys Asn Lys Gln Glu Leu
        595                 600                 605             
Ser Phe Tyr Ser Ile Pro Glu Phe Asp Glu Trp Lys Lys His Ile Glu
    610                 615                 620                 
Asn Gln Lys Ala Trp Lys Ile Lys Tyr Tyr Lys Gly Leu Gly Thr Ser
625                 630                 635                 640 
Thr Ala Lys Glu Ala Lys Glu Tyr Phe Ala Asp Met Glu Arg His Arg
                645                 650                 655     
Ile Leu Phe Arg Tyr Ala Gly Pro Glu Asp Asp Ala Ala Ile Thr Leu
            660                 665                 670         
Ala Phe Ser Lys Lys Lys Ile Asp Asp Arg Lys Glu Trp Leu Thr Asn
        675                 680                 685             
Phe Met Glu Asp Arg Arg Gln Arg Arg Leu His Gly Leu Pro Glu Gln
    690                 695                 700                 
Phe Leu Tyr Gly Thr Ala Thr Lys His Leu Thr Tyr Asn Asp Phe Ile
705                 710                 715                 720 
Asn Lys Glu Leu Ile Leu Phe Ser Asn Ser Asp Asn Glu Arg Ser Ile
                725                 730                 735     
Pro Ser Leu Val Asp Gly Phe Lys Pro Gly Gln Arg Lys Val Leu Phe
            740                 745                 750         
Thr Cys Phe Lys Arg Asn Asp Lys Arg Glu Val Lys Val Ala Gln Leu
        755                 760                 765             
Ala Gly Ser Val Ala Glu Met Ser Ala Tyr His His Gly Glu Gln Ala
    770                 775                 780                 
Leu Met Met Thr Ile Val Asn Leu Ala Gln Asn Phe Val Gly Ser Asn
785                 790                 795                 800 
Asn Ile Asn Leu Leu Gln Pro Ile Gly Gln Phe Gly Thr Arg Leu His
                805                 810                 815     
Gly Gly Lys Asp Ala Ala Ser Pro Arg Tyr Ile Phe Thr Met Leu Ser
            820                 825                 830         
Thr Leu Ala Arg Leu Leu Phe Pro Ala Val Asp Asp Asn Leu Leu Lys
        835                 840                 845             
Phe Leu Tyr Asp Asp Asn Gln Arg Val Glu Pro Glu Trp Tyr Ile Pro
    850                 855                 860                 
Ile Ile Pro Met Val Leu Ile Asn Gly Ala Glu Gly Ile Gly Thr Gly
865                 870                 875                 880 
Trp Ala Cys Lys Leu Pro Asn Tyr Asp Ala Arg Glu Ile Val Asn Asn
                885                 890                 895     
Val Arg Arg Met Leu Asp Gly Leu Asp Pro His Pro Met Leu Pro Asn
            900                 905                 910         
Tyr Lys Asn Phe Lys Gly Thr Ile Gln Glu Leu Gly Gln Asn Gln Tyr
        915                 920                 925             
Ala Val Ser Gly Glu Ile Phe Val Val Asp Arg Asn Thr Val Glu Ile
    930                 935                 940                 
Thr Glu Leu Pro Val Arg Thr Trp Thr Gln Val Tyr Lys Glu Gln Val
945                 950                 955                 960 
Leu Glu Pro Met Leu Asn Gly Thr Asp Lys Thr Pro Ala Leu Ile Ser
                965                 970                 975     
Asp Tyr Lys Glu Tyr His Thr Asp Thr Thr Val Lys Phe Val Val Lys
            980                 985                 990         
Met Thr Glu Glu Lys Leu Ala Gln Ala Glu Ala Ala Gly Leu His Lys
        995                 1000                1005            
Val Phe Lys Leu Gln Thr Thr Leu Thr Cys Asn Ser Met Val Leu Phe
    1010                1015                1020                
Asp His Met Gly Cys Leu Lys Lys Tyr Glu Thr Val Gln Asp Ile Leu
1025                1030                1035                1040
Lys Glu Phe Phe Asp Leu Arg Leu Ser Tyr Tyr Gly Leu Arg Lys Glu
                1045                1050                1055    
Trp Leu Val Gly Met Leu Gly Ala Glu Ser Thr Lys Leu Asn Asn Gln
            1060                1065                1070        
Ala Arg Phe Ile Leu Glu Lys Ile Gln Gly Lys Ile Thr Ile Glu Asn
        1075                1080                1085            
Arg Ser Lys Lys Asp Leu Ile Gln Met Leu Val Gln Arg Gly Tyr Glu
    1090                1095                1100                
Ser Asp Pro Val Lys Ala Trp Lys Glu Ala Gln Glu Lys Ala Ala Glu
1105                1110                1115                1120
Glu Asp Glu Thr Gln Asn Gln His Asp Asp Ser Ser Ser Asp Ser Gly
                1125                1130                1135    
Thr Pro Ser Gly Pro Asp Phe Asn Tyr Ile Leu Asn Met Ser Leu Trp
            1140                1145                1150        
Ser Leu Thr Lys Glu Lys Val Glu Glu Leu Ile Lys Gln Arg Asp Ala
        1155                1160                1165            
Lys Gly Arg Glu Val Asn Asp Leu Lys Arg Lys Ser Pro Ser Asp Leu
    1170                1175                1180                
Trp Lys Glu Asp Leu Ala Ala Phe Val Glu Glu Leu Asp Lys Val Glu
1185                1190                1195                1200
Ser Gln Glu Arg Glu Asp Val Leu Ala Gly Met Ser Gly Lys Ala Ile
                1205                1210                1215    
Lys Gly Lys Val Gly Lys Pro Lys Val Lys Lys Leu Gln Leu Glu Glu
            1220                1225                1230        
Thr Met Pro Ser Pro Tyr Gly Arg Arg Ile Ile Pro Glu Ile Thr Ala
        1235                1240                1245            
Met Lys Ala Asp Ala Ser Lys Lys Leu Leu Lys Lys Lys Lys Gly Asp
    1250                1255                1260                
Leu Asp Thr Ala Ala Val Lys Val Glu Phe Asp Glu Glu Phe Ser Gly
1265                1270                1275                1280
Ala Pro Val Glu Gly Ala Gly Glu Glu Ala Leu Thr Pro Ser Val Pro
                1285                1290                1295    
Ile Asn Lys Gly Pro Lys Pro Lys Arg Glu Lys Lys Glu Pro Gly Thr
            1300                1305                1310        
Arg Val Arg Lys Thr Pro Thr Ser Ser Gly Lys Pro Ser Ala Lys Lys
        1315                1320                1325            
Val Lys Lys Arg Asn Pro Trp Ser Asp Asp Glu Ser Lys Ser Glu Ser
    1330                1335                1340                
Asp Leu Glu Glu Thr Glu Pro Val Val Ile Pro Arg Asp Ser Leu Leu
1345                1350                1355                1360
Arg Arg Ala Ala Ala Glu Arg Pro Lys Tyr Thr Phe Asp Phe Ser Glu
                1365                1370                1375    
Glu Glu Asp Asp Asp Ala Asp Asp Asp Asp Asp Asp Asn Asn Asp Leu
            1380                1385                1390        
Glu Glu Leu Lys Val Lys Ala Ser Pro Ile Thr Asn Asp Gly Glu Asp
        1395                1400                1405            
Glu Phe Val Pro Ser Asp Gly Leu Asp Lys Asp Glu Tyr Thr Phe Ser
    1410                1415                1420                
Pro Gly Lys Ser Lys Ala Thr Pro Glu Lys Ser Leu His Asp Lys Lys
1425                1430                1435                1440
Ser Gln Asp Phe Gly Asn Leu Phe Ser Phe Pro Ser Tyr Ser Gln Lys
                1445                1450                1455    
Ser Glu Asp Asp Ser Ala Lys Phe Asp Ser Asn Glu Glu Asp Ser Ala
            1460                1465                1470        
Ser Val Phe Ser Pro Ser Phe Gly Leu Lys Gln Thr Asp Lys Val Pro
        1475                1480                1485            
Ser Lys Thr Val Ala Ala Lys Lys Gly Lys Pro Ser Ser Asp Thr Val
    1490                1495                1500                
Pro Lys Pro Lys Arg Ala Pro Lys Gln Lys Lys Val Val Glu Ala Val
1505                1510                1515                1520
Asn Ser Asp Ser Asp Ser Glu Phe Gly Ile Pro Lys Lys Thr Thr Thr
                1525                1530                1535    
Pro Lys Gly Lys Gly Arg Gly Ala Lys Lys Arg Lys Ala Ser Gly Ser
            1540                1545                1550        
Glu Asn Glu Gly Asp Tyr Asn Pro Gly Arg Lys Thr Ser Lys Thr Thr
        1555                1560                1565            
Ser Lys Lys Pro Lys Lys Thr Ser Phe Asp Gln Asp Ser Asp Val Asp
    1570                1575                1580                
Ile Phe Pro Ser Asp Phe Pro Thr Glu Pro Pro Ser Leu Pro Arg Thr
1585                1590                1595                1600
Gly Arg Ala Arg Lys Glu Val Lys Tyr Phe Ala Glu Ser Asp Glu Glu
                1605                1610                1615    
Glu Asp Asp Val Asp Phe Ala Met Phe Asn
            1620                1625    


<210> 3018
<211> 1104
<212> PRT
<213> Homo sapiens

<400> 3018
Met Ser Phe Arg Ala Ala Arg Leu Ser Met Arg Asn Arg Arg Asn Asp
 1               5                  10                  15      
Thr Leu Asp Ser Thr Arg Thr Leu Tyr Ser Ser Ala Ser Arg Ser Thr
            20                  25                  30          
Asp Leu Ser Tyr Ser Glu Ser Asp Leu Val Asn Phe Ile Gln Ala Asn
        35                  40                  45              
Phe Lys Lys Arg Glu Cys Val Phe Phe Ile Lys Asp Ser Lys Ala Thr
    50                  55                  60                  
Glu Asn Val Cys Lys Cys Gly Tyr Ala Gln Ser Gln His Met Glu Gly
65                  70                  75                  80  
Thr Gln Ile Asn Gln Ser Glu Lys Trp Asn Tyr Lys Lys His Thr Lys
                85                  90                  95      
Glu Phe Pro Thr Asp Ala Phe Gly Asp Ile Gln Phe Glu Thr Leu Gly
            100                 105                 110         
Lys Lys Gly Lys Tyr Ile Arg Leu Ser Cys Asp Thr Asp Ala Glu Ile
        115                 120                 125             
Leu Tyr Glu Leu Leu Thr Gln His Trp His Leu Lys Thr Pro Asn Leu
    130                 135                 140                 
Val Ile Ser Val Thr Gly Gly Ala Lys Asn Phe Ala Leu Lys Pro Arg
145                 150                 155                 160 
Met Arg Lys Ile Phe Ser Arg Leu Ile Tyr Ile Ala Gln Ser Lys Gly
                165                 170                 175     
Ala Trp Ile Leu Thr Gly Gly Thr His Tyr Gly Leu Met Lys Tyr Ile
            180                 185                 190         
Gly Glu Val Val Arg Asp Asn Thr Ile Ser Arg Ser Ser Glu Glu Asn
        195                 200                 205             
Ile Val Ala Ile Gly Ile Ala Ala Trp Gly Met Val Ser Asn Arg Asp
    210                 215                 220                 
Thr Leu Ile Arg Asn Cys Asp Ala Glu Gly Tyr Phe Leu Ala Gln Tyr
225                 230                 235                 240 
Leu Met Asp Asp Phe Thr Arg Asp Pro Leu Tyr Ile Leu Asp Asn Asn
                245                 250                 255     
His Thr His Leu Leu Leu Val Asp Asn Gly Cys His Gly His Pro Thr
            260                 265                 270         
Val Glu Ala Lys Leu Arg Asn Gln Leu Glu Lys Tyr Ile Ser Glu Arg
        275                 280                 285             
Thr Ile Gln Asp Ser Asn Tyr Gly Gly Lys Ile Pro Ile Val Cys Phe
    290                 295                 300                 
Ala Gln Gly Gly Gly Lys Glu Thr Leu Lys Ala Ile Asn Thr Ser Ile
305                 310                 315                 320 
Lys Asn Lys Ile Pro Cys Val Val Val Glu Gly Ser Gly Gln Ile Ala
                325                 330                 335     
Asp Val Ile Ala Ser Leu Val Glu Val Glu Asp Ala Leu Thr Ser Ser
            340                 345                 350         
Ala Val Lys Glu Lys Leu Val Arg Phe Leu Pro Arg Thr Val Ser Arg
        355                 360                 365             
Leu Pro Glu Glu Glu Thr Glu Ser Trp Ile Lys Trp Leu Lys Glu Ile
    370                 375                 380                 
Leu Glu Cys Ser His Leu Leu Thr Val Ile Lys Met Glu Glu Ala Gly
385                 390                 395                 400 
Asp Glu Ile Val Ser Asn Ala Ile Ser Tyr Ala Leu Tyr Lys Ala Phe
                405                 410                 415     
Ser Thr Ser Glu Gln Asp Lys Asp Asn Trp Asn Gly Gln Leu Lys Leu
            420                 425                 430         
Leu Leu Glu Trp Asn Gln Leu Asp Leu Ala Asn Asp Glu Ile Phe Thr
        435                 440                 445             
Asn Asp Arg Arg Trp Glu Ser Ala Asp Leu Gln Glu Val Met Phe Thr
    450                 455                 460                 
Ala Leu Ile Lys Asp Arg Pro Lys Phe Val Arg Leu Phe Leu Glu Asn
465                 470                 475                 480 
Gly Leu Asn Leu Arg Lys Phe Leu Thr His Asp Val Leu Thr Glu Leu
                485                 490                 495     
Phe Ser Asn His Phe Ser Thr Leu Val Tyr Arg Asn Leu Gln Ile Ala
            500                 505                 510         
Lys Asn Ser Tyr Asn Asp Ala Leu Leu Thr Phe Val Trp Lys Leu Val
        515                 520                 525             
Ala Asn Phe Arg Arg Gly Phe Arg Lys Glu Asp Arg Asn Gly Arg Asp
    530                 535                 540                 
Glu Met Asp Ile Glu Leu His Asp Val Ser Pro Ile Thr Arg His Pro
545                 550                 555                 560 
Leu Gln Ala Leu Phe Ile Trp Ala Ile Leu Gln Asn Lys Lys Glu Leu
                565                 570                 575     
Ser Lys Val Ile Trp Glu Gln Thr Arg Gly Cys Thr Leu Ala Ala Leu
            580                 585                 590         
Gly Ala Ser Lys Leu Leu Lys Thr Leu Ala Lys Val Lys Asn Asp Ile
        595                 600                 605             
Asn Ala Ala Gly Glu Ser Glu Glu Leu Ala Asn Glu Tyr Glu Thr Arg
    610                 615                 620                 
Ala Val Glu Leu Phe Thr Glu Cys Tyr Ser Ser Asp Glu Asp Leu Ala
625                 630                 635                 640 
Glu Gln Leu Leu Val Tyr Ser Cys Glu Ala Trp Gly Gly Ser Asn Cys
                645                 650                 655     
Leu Glu Leu Ala Val Glu Ala Thr Asp Gln His Phe Ile Ala Gln Pro
            660                 665                 670         
Gly Val Gln Asn Phe Leu Ser Lys Gln Trp Tyr Gly Glu Ile Ser Arg
        675                 680                 685             
Asp Thr Lys Asn Trp Lys Ile Ile Leu Cys Leu Phe Ile Ile Pro Leu
    690                 695                 700                 
Val Gly Cys Gly Phe Val Ser Phe Arg Lys Lys Pro Val Asp Lys His
705                 710                 715                 720 
Lys Lys Leu Leu Trp Tyr Tyr Val Ala Phe Phe Thr Ser Pro Phe Val
                725                 730                 735     
Val Phe Ser Trp Asn Val Val Phe Tyr Ile Ala Phe Leu Leu Leu Phe
            740                 745                 750         
Ala Tyr Val Leu Leu Met Asp Phe His Ser Val Pro His Pro Pro Glu
        755                 760                 765             
Leu Val Leu Tyr Ser Leu Val Phe Val Leu Phe Cys Asp Glu Val Arg
    770                 775                 780                 
Gln Trp Tyr Val Asn Gly Val Asn Tyr Phe Thr Asp Leu Trp Asn Val
785                 790                 795                 800 
Met Asp Thr Leu Gly Leu Phe Tyr Phe Ile Ala Gly Ile Val Phe Arg
                805                 810                 815     
Leu His Ser Ser Asn Lys Ser Ser Leu Tyr Ser Gly Arg Val Ile Phe
            820                 825                 830         
Cys Leu Asp Tyr Ile Ile Phe Thr Leu Arg Leu Ile His Ile Phe Thr
        835                 840                 845             
Val Ser Arg Asn Leu Gly Pro Lys Ile Ile Met Leu Gln Arg Met Leu
    850                 855                 860                 
Ile Asp Val Phe Phe Phe Leu Phe Leu Phe Ala Val Trp Met Val Ala
865                 870                 875                 880 
Phe Gly Val Ala Arg Gln Gly Ile Leu Arg Gln Asn Glu Gln Arg Trp
                885                 890                 895     
Arg Trp Ile Phe Arg Ser Val Ile Tyr Glu Pro Tyr Leu Ala Met Phe
            900                 905                 910         
Gly Gln Val Pro Ser Asp Val Asp Gly Thr Thr Tyr Asp Phe Ala His
        915                 920                 925             
Cys Thr Phe Thr Gly Asn Glu Ser Lys Pro Leu Cys Val Glu Leu Asp
    930                 935                 940                 
Glu His Asn Leu Pro Arg Phe Pro Glu Trp Ile Thr Ile Pro Leu Val
945                 950                 955                 960 
Cys Ile Tyr Met Leu Ser Thr Asn Ile Leu Leu Val Asn Leu Leu Val
                965                 970                 975     
Ala Met Phe Gly Tyr Thr Val Gly Thr Val Gln Glu Asn Asn Asp Gln
            980                 985                 990         
Val Trp Lys Phe Gln Arg Tyr Phe Leu Val Gln Glu Tyr Cys Ser Arg
        995                 1000                1005            
Leu Asn Ile Pro Phe Pro Phe Ile Val Phe Ala Tyr Phe Tyr Met Val
    1010                1015                1020                
Val Lys Lys Cys Phe Lys Cys Cys Cys Lys Glu Lys Asn Met Glu Ser
1025                1030                1035                1040
Ser Val Cys Cys Phe Lys Asn Glu Asp Asn Glu Thr Leu Ala Trp Glu
                1045                1050                1055    
Gly Val Met Lys Glu Asn Tyr Leu Val Lys Ile Asn Thr Lys Ala Asn
            1060                1065                1070        
Asp Thr Ser Glu Glu Met Arg His Arg Phe Arg Gln Leu Asp Thr Lys
        1075                1080                1085            
Leu Asn Asp Leu Lys Gly Leu Leu Lys Glu Ile Ala Asn Lys Ile Lys
    1090                1095                1100                


<210> 3019
<211> 146
<212> PRT
<213> Homo sapiens

<400> 3019
Met His Leu Thr Pro Glu Glu Lys Ser Ala Val Thr Ala Leu Trp Gly
 1               5                  10                  15      
Lys Val Asn Val Asp Glu Val Gly Gly Glu Ala Leu Gly Arg Leu Leu
            20                  25                  30          
Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp Leu
        35                  40                  45              
Ser Thr Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His Gly
    50                  55                  60                  
Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp Asn
65                  70                  75                  80  
Leu Lys Gly Thr Phe Ala Thr Leu Ser Glu Leu His Cys Asp Lys Leu
                85                  90                  95      
His Val Asp Pro Glu Asn Phe Arg Leu Leu Gly Asn Val Leu Val Cys
            100                 105                 110         
Val Leu Ala His His Phe Gly Lys Glu Phe Thr Pro Pro Val Gln Ala
        115                 120                 125             
Ala Tyr Gln Lys Val Val Ala Gly Val Ala Asn Ala Leu Ala His Lys
    130                 135                 140                 
Tyr His
145     


<210> 3020
<211> 505
<212> PRT
<213> Homo sapiens

<400> 3020
Ser Glu Ala Val Ala Asp Arg Glu Asp Asp Pro Asn Phe Phe Lys Met
 1               5                  10                  15      
Val Glu Gly Phe Phe Asp Arg Gly Ala Ser Ile Val Glu Asp Lys Leu
            20                  25                  30          
Val Glu Asp Leu Arg Thr Arg Glu Ser Glu Glu Gln Lys Arg Asn Arg
        35                  40                  45              
Val Arg Gly Ile Leu Arg Ile Ile Lys Pro Cys Asn His Val Leu Ser
    50                  55                  60                  
Leu Ser Phe Pro Ile Arg Arg Asp Asp Gly Ser Trp Glu Val Ile Glu
65                  70                  75                  80  
Gly Tyr Arg Ala Gln His Ser Gln His Arg Thr Pro Cys Lys Gly Gly
                85                  90                  95      
Ile Arg Tyr Ser Thr Asp Val Ser Val Asp Glu Val Lys Ala Leu Ala
            100                 105                 110         
Ser Leu Met Thr Tyr Lys Cys Ala Val Val Asp Val Pro Phe Gly Gly
        115                 120                 125             
Ala Lys Ala Gly Val Lys Ile Asn Pro Lys Asn Tyr Thr Asp Asn Glu
    130                 135                 140                 
Leu Glu Lys Ile Thr Arg Arg Phe Thr Met Glu Leu Ala Lys Lys Gly
145                 150                 155                 160 
Phe Ile Gly Pro Gly Ile Asp Val Pro Ala Pro Asp Met Ser Thr Gly
                165                 170                 175     
Glu Arg Glu Met Ser Trp Ile Ala Asp Thr Tyr Ala Ser Thr Ile Gly
            180                 185                 190         
His Tyr Asp Ile Asn Ala His Ala Cys Val Thr Gly Lys Pro Ile Ser
        195                 200                 205             
Gln Gly Gly Ile His Gly Arg Ile Ser Ala Thr Gly Arg Gly Val Phe
    210                 215                 220                 
His Gly Ile Glu Asn Phe Ile Asn Glu Ala Ser Tyr Met Ser Ile Leu
225                 230                 235                 240 
Gly Met Thr Pro Gly Phe Gly Asp Lys Thr Phe Val Val Gln Gly Phe
                245                 250                 255     
Gly Asn Val Gly Leu His Ser Met Arg Tyr Leu His Arg Phe Gly Ala
            260                 265                 270         
Lys Cys Ile Ala Val Gly Glu Ser Asp Gly Ser Ile Trp Asn Pro Asp
        275                 280                 285             
Gly Ile Asp Pro Lys Glu Leu Glu Asp Phe Lys Leu Gln His Gly Ser
    290                 295                 300                 
Ile Leu Gly Phe Pro Lys Ala Lys Pro Tyr Glu Gly Ser Ile Leu Glu
305                 310                 315                 320 
Ala Asp Cys Asp Ile Leu Ile Pro Ala Ala Ser Glu Lys Gln Leu Thr
                325                 330                 335     
Lys Ser Asn Ala Pro Arg Val Lys Ala Lys Ile Ile Ala Glu Gly Ala
            340                 345                 350         
Asn Gly Pro Thr Thr Pro Glu Ala Asp Lys Ile Phe Leu Glu Arg Asn
        355                 360                 365             
Ile Met Val Ile Pro Asp Leu Tyr Leu Asn Ala Gly Gly Val Thr Val
    370                 375                 380                 
Ser Tyr Phe Glu Trp Leu Lys Asn Leu Asn His Val Ser Tyr Gly Arg
385                 390                 395                 400 
Leu Thr Phe Lys Tyr Glu Arg Asp Ser Asn Tyr His Leu Leu Met Ser
                405                 410                 415     
Val Gln Glu Ser Leu Glu Arg Lys Phe Gly Lys His Gly Gly Thr Ile
            420                 425                 430         
Pro Ile Val Pro Thr Ala Glu Phe Gln Asp Arg Ile Ser Gly Ala Ser
        435                 440                 445             
Glu Lys Asp Ile Val His Ser Gly Leu Ala Tyr Thr Met Glu Arg Ser
    450                 455                 460                 
Ala Arg Gln Ile Met Arg Thr Ala Met Lys Tyr Asn Leu Gly Leu Asp
465                 470                 475                 480 
Leu Arg Thr Ala Ala Tyr Val Asn Ala Ile Glu Lys Val Phe Lys Val
                485                 490                 495     
Tyr Asn Glu Ala Gly Val Thr Phe Thr
            500                 505 


<210> 3021
<211> 485
<212> PRT
<213> Homo sapiens

<400> 3021
Glu Arg Gly Leu Glu Thr Asn Ser Cys Ser Glu Glu Glu Leu Ser Ser
 1               5                  10                  15      
Pro Gly Arg Gly Gly Gly Gly Gly Gly Arg Leu Leu Leu Gln Pro Pro
            20                  25                  30          
Gly Pro Glu Leu Pro Pro Val Pro Phe Pro Leu Gln Asp Leu Val Pro
        35                  40                  45              
Leu Gly Arg Leu Ser Arg Gly Glu Gln Gln Gln Gln Gln Gln Gln Gln
    50                  55                  60                  
Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro Leu Arg Pro Leu Ala Gly
65                  70                  75                  80  
Pro Ser Arg Lys Gly Ser Phe Lys Ile Arg Leu Ser Arg Leu Phe Arg
                85                  90                  95      
Thr Lys Ser Cys Asn Gly Gly Ser Gly Gly Gly Asp Gly Thr Gly Lys
            100                 105                 110         
Arg Pro Ser Gly Glu Leu Ala Ala Ser Ala Ala Ser Leu Thr Asp Met
        115                 120                 125             
Gly Gly Ser Ala Gly Arg Glu Leu Asp Ala Gly Arg Lys Pro Lys Leu
    130                 135                 140                 
Thr Arg Thr Gln Ser Ala Phe Ser Pro Val Ser Phe Ser Pro Leu Phe
145                 150                 155                 160 
Thr Gly Glu Thr Val Ser Leu Val Asp Val Asp Ile Ser Gln Arg Gly
                165                 170                 175     
Leu Thr Ser Pro His Pro Pro Thr Pro Pro Pro Pro Pro Arg Arg Ser
            180                 185                 190         
Leu Ser Leu Leu Asp Asp Ile Ser Gly Thr Leu Pro Thr Ser Val Leu
        195                 200                 205             
Val Ala Pro Met Gly Ser Ser Leu Gln Ser Phe Pro Leu Pro Pro Pro
    210                 215                 220                 
Pro Pro Pro His Ala Pro Asp Ala Phe Pro Arg Ile Ala Pro Ile Arg
225                 230                 235                 240 
Ala Ala Glu Ser Leu His Ser Gln Pro Pro Gln His Leu Gln Cys Pro
                245                 250                 255     
Leu Tyr Arg Pro Asp Ser Ser Ser Phe Ala Ala Ser Leu Arg Glu Leu
            260                 265                 270         
Glu Lys Cys Gly Trp Tyr Trp Gly Pro Met Asn Trp Glu Asp Ala Glu
        275                 280                 285             
Met Lys Leu Lys Gly Lys Pro Asp Gly Ser Phe Leu Val Arg Asp Ser
    290                 295                 300                 
Ser Asp Pro Arg Tyr Ile Leu Ser Leu Ser Phe Arg Ser Gln Gly Ile
305                 310                 315                 320 
Thr His His Thr Arg Met Glu His Tyr Arg Gly Thr Phe Ser Leu Trp
                325                 330                 335     
Cys His Pro Lys Phe Glu Asp Arg Cys Gln Ser Val Val Glu Phe Ile
            340                 345                 350         
Lys Arg Ala Ile Met His Ser Lys Asn Gly Lys Phe Leu Tyr Phe Leu
        355                 360                 365             
Arg Ser Arg Val Pro Gly Leu Pro Pro Thr Pro Val Gln Leu Leu Tyr
    370                 375                 380                 
Pro Val Ser Arg Phe Ser Asn Val Lys Ser Leu Gln His Leu Cys Arg
385                 390                 395                 400 
Phe Arg Ile Arg Gln Leu Val Arg Ile Asp His Ile Pro Asp Leu Pro
                405                 410                 415     
Leu Pro Lys Pro Leu Ile Ser Tyr Ile Arg Lys Phe Tyr Tyr Tyr Asp
            420                 425                 430         
Pro Gln Glu Glu Val Tyr Leu Ser Leu Lys Glu Ala Gln Leu Ile Ser
        435                 440                 445             
Lys Gln Lys Gln Glu Val Glu Pro Ser Thr Trp Arg Gly Ala Pro Arg
    450                 455                 460                 
Trp Ser Pro Pro Arg Ala Phe Gly Cys Gln Ala Pro Ala Leu Lys Asn
465                 470                 475                 480 
Gln Ile Lys Leu Pro
                485 


<210> 3022
<211> 471
<212> PRT
<213> Homo sapiens

<400> 3022
Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly
 1               5                  10                  15      
Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu
            20                  25                  30          
Leu Ile Gln Lys Thr Ile Lys Lys Gln Val Val Leu Glu Glu Gly Thr
        35                  40                  45              
Ile Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Glu Val Tyr Arg Gln
    50                  55                  60                  
Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser
65                  70                  75                  80  
Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg
                85                  90                  95      
Phe Leu Ala Lys Glu Asn Val Thr Gln Asp Ala Glu Asp Asn Thr Val
            100                 105                 110         
Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val
        115                 120                 125             
Gly Thr Glu Ala Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Ala
    130                 135                 140                 
Ala Ser His Ile Tyr Gln Asn Gln Phe Val Gln Met Ile Leu Asn Ser
145                 150                 155                 160 
Leu Ile Asn Lys Ser Lys Ser Ser Met Phe Gln Val Arg Thr Leu Arg
                165                 170                 175     
Glu Leu Leu Trp Gly Tyr Arg Asp Pro Phe Leu Ser Leu Val Pro Tyr
            180                 185                 190         
Pro Val Thr Thr Thr Val Gly Leu Phe Tyr Pro Tyr Asn Asn Thr Ala
        195                 200                 205             
Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn Ile Ser Lys Val
    210                 215                 220                 
Ala Ile Ile Asp Thr Tyr Lys Gly Lys Arg Asn Leu Ser Tyr Trp Glu
225                 230                 235                 240 
Ser His Cys Asp Met Ile Asn Gly Thr Asp Ala Ala Ser Phe Pro Pro
                245                 250                 255     
Phe Val Glu Lys Ser Gln Val Leu His Ser Phe Phe Ser Val Phe Arg
            260                 265                 270         
Ser Ile Tyr Ala Val Phe Glu Ser Asp Val Asn Leu Lys Gly Ile Pro
        275                 280                 285             
Val Tyr Arg Phe Val Leu Pro Ser Lys Ala Phe Ala Ser Pro Val Glu
    290                 295                 300                 
Asn Pro Asp Asn Tyr Cys Phe Cys Thr Glu Lys Ile Ile Ser Lys Asn
305                 310                 315                 320 
Cys Thr Ser Tyr Gly Val Leu Asp Ile Ser Lys Cys Lys Glu Gly Arg
                325                 330                 335     
Pro Val Tyr Ile Ser Leu Pro His Phe Leu Tyr Ala Ser Pro Asp Val
            340                 345                 350         
Ser Glu Pro Ile Asp Gly Leu Asn Pro Asn Glu Glu Glu His Arg Thr
        355                 360                 365             
Tyr Leu Asp Ile Glu Pro Ile Thr Gly Phe Thr Leu Gln Phe Ala Lys
    370                 375                 380                 
Arg Leu Gln Val Asn Leu Leu Val Lys Pro Ser Glu Lys Ile Gln Val
385                 390                 395                 400 
Leu Lys Asn Leu Lys Arg Asn Tyr Ile Val Pro Ile Leu Trp Leu Asn
                405                 410                 415     
Glu Thr Gly Thr Ile Gly Asp Glu Lys Ala Asn Met Phe Arg Ser Gln
            420                 425                 430         
Val Thr Gly Lys Ile Asn Leu Leu Gly Leu Ile Glu Met Ile Leu Leu
        435                 440                 445             
Ser Val Gly Val Val Met Phe Val Ala Phe Met Ile Ser Tyr Cys Ala
    450                 455                 460                 
Cys Arg Ser Lys Thr Ile Lys
465                 470     


<210> 3023
<211> 730
<212> PRT
<213> Homo sapiens

<400> 3023
Met Ser Lys Asn Ser Glu Phe Ile Asn Leu Ser Phe Leu Leu Asp His
 1               5                  10                  15      
Glu Lys Glu Met Ile Leu Gly Val Leu Lys Arg Asp Glu Tyr Leu Lys
            20                  25                  30          
Lys Val Glu Asp Lys Arg Ile Arg Lys Leu Lys Asn Glu Leu Leu Glu
        35                  40                  45              
Ala Lys Arg Arg Ser Gly Lys Thr Gln Gln Glu Ala Ser Arg Val Cys
    50                  55                  60                  
Val His Cys His Arg Asn Leu Gly Leu Ile Phe Asp Arg Gly Asp Pro
65                  70                  75                  80  
Cys Gln Ala Cys Ser Leu Arg Val Cys Arg Glu Cys Arg Val Ala Gly
                85                  90                  95      
Pro Asn Gly Ser Trp Lys Cys Thr Val Cys Asp Lys Ile Ala Gln Leu
            100                 105                 110         
Arg Ile Ile Thr Gly Glu Trp Phe Phe Glu Glu Lys Ala Lys Arg Phe
        115                 120                 125             
Lys Gln Val Asn Val Leu Gly Thr Asp Val Val Arg Gln Ser Ile Leu
    130                 135                 140                 
Arg Arg Ser Pro Gly Ala Glu Glu Val Gln Ser Gln Glu Gln Thr Arg
145                 150                 155                 160 
Gln Asp Ala Glu Lys Ser Asp Thr Ser Pro Val Ala Gly Lys Lys Ala
                165                 170                 175     
Ser His Asp Gly Pro Lys Arg Lys Gly Phe Leu Leu Ser Lys Phe Arg
            180                 185                 190         
Ser Ala Thr Arg Gly Glu Ile Ile Thr Pro Lys Thr Asp Thr Gly Arg
        195                 200                 205             
Ser Tyr Ser Leu Asp Leu Asp Gly Gln His Phe Arg Ser Leu Lys Ser
    210                 215                 220                 
Pro Pro Gly Ser Asp Arg Gly Ser Thr Gly Ser Ser Asp Leu Asn Asp
225                 230                 235                 240 
Gln Glu Pro Gly Pro Arg Thr Pro Lys Ser Ser Arg Ser Asn Gly Val
                245                 250                 255     
Thr Pro Gly Thr Gln Ser Ser Pro Ala Pro Ser Thr Arg Thr Val Thr
            260                 265                 270         
Ser Val Ile Ser Arg Glu Tyr Gly Phe Glu Asn Ser Met Asp Leu Ala
        275                 280                 285             
Ala Ile Glu Gly Thr Ser Gln Glu Leu Thr Lys Ser His Arg Arg Asn
    290                 295                 300                 
Thr Ser Gly Thr Pro Ser Ile Ala Val Ser Gly Thr Ser Leu Ser Ser
305                 310                 315                 320 
Asp Gln Ser Arg Ser Glu Leu Asp Leu Ser Glu Ser Phe Thr Glu Asp
                325                 330                 335     
Ser Glu Asp Thr Val Ser Ile Arg Ser Lys Ser Val Pro Gly Ala Leu
            340                 345                 350         
Asp Lys Asp Ser Leu Glu Glu Thr Glu Glu Ser Ile Asp Ala Leu Val
        355                 360                 365             
Ser Ser Gln Leu Ser Thr Asn Thr His Arg Leu Ala Ser Gly Leu Ser
    370                 375                 380                 
Thr Thr Ser Leu Asn Ser Met Met Ser Val Tyr Ser Glu Thr Gly Asp
385                 390                 395                 400 
Tyr Gly Asn Val Lys Val Ser Gly Glu Ile Leu Leu His Ile Ser Tyr
                405                 410                 415     
Cys Tyr Lys Thr Gly Gly Leu Tyr Ile Phe Val Lys Asn Cys Arg Asn
            420                 425                 430         
Leu Ala Ile Gly Asp Glu Lys Lys Gln Arg Thr Asp Ala Tyr Val Lys
        435                 440                 445             
Ser Tyr Leu Leu Pro Asp Lys Ser Arg Asn Asn Lys Arg Lys Thr Lys
    450                 455                 460                 
Ile Arg Thr Gly Thr Asn Pro Glu Phe Asn Glu Thr Leu Lys Tyr Thr
465                 470                 475                 480 
Ile Ser His Thr Gln Leu Glu Thr Arg Thr Leu Gln Leu Ser Val Trp
                485                 490                 495     
His Tyr Asp Arg Phe Gly Arg Asn Ser Phe Leu Gly Glu Val Glu Ile
            500                 505                 510         
Pro Phe Asp Ser Trp Asn Phe Glu Asn Pro Thr Asp Glu Trp Phe Val
        515                 520                 525             
Leu Gln Pro Lys Val Glu Phe Ala Pro Asp Ile Gly Leu Gln Tyr Lys
    530                 535                 540                 
Gly Glu Leu Thr Val Val Leu Arg Tyr Ile Pro Pro Glu Glu Asn Leu
545                 550                 555                 560 
Met Leu Pro Pro Glu Gln Leu Gln Gly Asn Lys Thr Phe Lys Lys Gly
                565                 570                 575     
Lys Lys Lys Glu Ser Pro Val Ile Ser Gly Gly Ile Leu Glu Val Phe
            580                 585                 590         
Ile Lys Glu Ala Lys Asn Leu Thr Ala Val Lys Ser Gly Gly Thr Ser
        595                 600                 605             
Asp Ser Phe Val Lys Gly Tyr Leu Leu Pro Asp Asp Ser Lys Ala Thr
    610                 615                 620                 
Lys His Lys Thr Leu Val Ile Lys Lys Ser Val Asn Pro Gln Trp Asn
625                 630                 635                 640 
His Thr Phe Met Phe Ser Gly Ile His Pro Gln Asp Ile Lys Asn Val
                645                 650                 655     
Cys Leu Glu Leu Thr Ile Trp Asp Lys Glu Ala Phe Ser Ser Asn Ile
            660                 665                 670         
Phe Leu Gly Gly Val Arg Leu Asn Ser Gly Ser Gly Val Ser His Gly
        675                 680                 685             
Lys Asn Val Asp Trp Met Asp Ser Gln Gly Glu Glu Gln Arg Leu Trp
    690                 695                 700                 
Gln Lys Met Ala Asn Asn Pro Gly Thr Pro Phe Glu Gly Val Leu Met
705                 710                 715                 720 
Leu Arg Ser Ser Met Gly Lys Cys Arg Leu
                725                 730 


<210> 3024
<211> 4074
<212> PRT
<213> Homo sapiens

<400> 3024
Met Thr Ala Trp Leu Ile Ser Leu Met Ser Ile Glu Val Leu Leu Leu
 1               5                  10                  15      
Ala Val Arg His Leu Ser Leu His Ile Glu Pro Glu Glu Gly Ser Leu
            20                  25                  30          
Ala Gly Gly Thr Trp Ile Thr Val Ile Phe Asp Gly Leu Glu Leu Gly
        35                  40                  45              
Val Leu Tyr Pro Asn Asn Gly Ser Gln Leu Glu Ile His Leu Val Asn
    50                  55                  60                  
Val Asn Met Val Val Pro Ala Leu Arg Ser Val Pro Cys Asp Val Phe
65                  70                  75                  80  
Pro Val Phe Leu Asp Leu Pro Val Val Thr Cys Arg Thr Arg Ser Val
                85                  90                  95      
Leu Ser Glu Ala His Glu Gly Leu Tyr Phe Leu Glu Ala Tyr Phe Gly
            100                 105                 110         
Gly Gln Leu Val Ser Ser Pro Asn Pro Gly Pro Arg Asp Ser Cys Thr
        115                 120                 125             
Phe Lys Phe Ser Lys Ala Gln Thr Pro Ile Val His Gln Val Tyr Pro
    130                 135                 140                 
Pro Ser Gly Val Pro Gly Lys Leu Ile His Val Tyr Gly Trp Ile Ile
145                 150                 155                 160 
Thr Gly Arg Leu Glu Thr Phe Asp Phe Asp Ala Glu Tyr Ile Asp Ser
                165                 170                 175     
Pro Val Ile Leu Glu Ala Gln Gly Asp Lys Trp Val Thr Pro Cys Ser
            180                 185                 190         
Leu Ile Asn Arg Gln Met Gly Ser Cys Tyr Pro Ile Gln Glu Asp His
        195                 200                 205             
Gly Leu Gly Thr Leu Gln Cys His Val Glu Gly Asp Tyr Ile Gly Ser
    210                 215                 220                 
Gln Asn Val Ser Phe Ser Val Phe Asn Lys Gly Lys Ser Met Val His
225                 230                 235                 240 
Lys Lys Ala Trp Leu Ile Ser Ala Lys Gln Asp Leu Phe Leu Tyr Gln
                245                 250                 255     
Thr His Ser Glu Ile Leu Ser Val Phe Pro Glu Thr Gly Ser Leu Gly
            260                 265                 270         
Gly Arg Thr Asn Ile Thr Ile Thr Gly Asp Phe Phe Asp Asn Ser Ala
        275                 280                 285             
Gln Val Thr Ile Ala Gly Ile Pro Cys Asp Ile Arg His Val Ser Pro
    290                 295                 300                 
Arg Lys Ile Glu Cys Thr Thr Arg Ala Pro Gly Lys Asp Val Arg Leu
305                 310                 315                 320 
Thr Thr Pro Gln Pro Gly Asn Arg Gly Leu Leu Phe Glu Val Gly Asp
                325                 330                 335     
Ala Val Glu Gly Leu Glu Leu Thr Glu Ala Thr Pro Gly Tyr Arg Trp
            340                 345                 350         
Gln Ile Val Pro Asn Ala Ser Ser Pro Phe Gly Phe Trp Ser Gln Glu
        355                 360                 365             
Gly Gln Pro Phe Arg Ala Arg Leu Ser Gly Phe Phe Val Ala Pro Glu
    370                 375                 380                 
Thr Asn Asn Tyr Thr Phe Trp Ile Gln Ala Asp Ser Gln Ala Ser Leu
385                 390                 395                 400 
His Phe Ser Trp Ser Glu Glu Pro Arg Thr Lys Val Lys Val Ala Ser
                405                 410                 415     
Ile Ser Val Gly Thr Ala Asp Trp Phe Asp Ser Trp Glu Gln Asn Arg
            420                 425                 430         
Asp Glu Gly Thr Trp Gln Gln Lys Thr Pro Lys Leu Glu Leu Leu Gly
        435                 440                 445             
Gly Ala Met Tyr Tyr Leu Glu Ala Glu His His Gly Ile Ala Pro Ser
    450                 455                 460                 
Arg Gly Met Arg Ile Gly Val Gln Ile His Asn Thr Trp Leu Asn Pro
465                 470                 475                 480 
Asp Val Val Thr Thr Tyr Leu Arg Glu Lys His Gln Ile Arg Val Arg
                485                 490                 495     
Ala Gln Arg Leu Pro Glu Val Gln Val Leu Asn Val Ser Gly Arg Gly
            500                 505                 510         
Asn Phe Phe Leu Thr Trp Asp Asn Val Ser Ser Gln Pro Ile Pro Ala
        515                 520                 525             
Asn Ala Thr Ala His Leu Ile Gln Thr Thr Ile Glu Glu Leu Leu Ala
    530                 535                 540                 
Val Lys Cys Lys Leu Glu Pro Leu Trp Ser Asn Ile Leu Leu Arg Leu
545                 550                 555                 560 
Gly Phe Glu Arg Gly Pro Glu Val Ser Asn Ser Asp Gly Asp Leu Thr
                565                 570                 575     
Ser Gly Thr Glu Pro Phe Cys Gly Arg Phe Ser Leu Arg Gln Pro Arg
            580                 585                 590         
His Leu Val Leu Thr Pro Pro Ala Ala Gln Lys Gly Tyr Arg Leu Asp
        595                 600                 605             
Gln Tyr Thr His Leu Cys Leu Ala Tyr Lys Gly His Met Asn Lys Ile
    610                 615                 620                 
Leu Lys Met Ile Val Ser Phe Thr Ile Gly Phe Gln Asn Met Val Lys
625                 630                 635                 640 
Asn Thr Thr Cys Asp Trp Ser Leu Thr Arg Thr Ser Pro Glu Ser Trp
                645                 650                 655     
Gln Phe Asp Cys Thr Asp Leu Trp Glu Thr Cys Val Arg Cys Phe Gly
            660                 665                 670         
Asp Leu Gln Pro Pro Pro Ala Asn Ser Pro Val Leu Val His Gln Ile
        675                 680                 685             
Asn Leu Leu Pro Leu Ala Gln Glu Thr Gly Leu Phe Tyr Val Asp Glu
    690                 695                 700                 
Ile Ile Ile Ala Asp Thr Asn Val Thr Val Ser Gln Ala Asp Ser Gly
705                 710                 715                 720 
Thr Ala Arg Pro Gly Gly Asn Leu Val Glu Ser Val Ser Val Val Gly
                725                 730                 735     
Ser Pro Pro Val Tyr Ser Val Thr Ser Trp Leu Ala Gly Cys Gly Thr
            740                 745                 750         
Glu Leu Pro Leu Ile Thr Ala Arg Ser Val Pro Thr Glu Gly Thr Glu
        755                 760                 765             
Glu Gly Ser Gly Leu Val Leu Val Thr Thr Gln Arg Arg Gln Arg Thr
    770                 775                 780                 
Ser Pro Pro Leu Gly Gly His Phe Arg Ile Gln Leu Pro Asn Thr Val
785                 790                 795                 800 
Ile Ser Asp Val Pro Val Gln Ile Ser Ala His His Leu His Gln Leu
                805                 810                 815     
Leu Gln Asn Asn Ala Asp Asp Phe Thr Ser Arg Tyr Leu Asn Ala Ser
            820                 825                 830         
Asp Phe Thr Val Lys Glu Asp Leu Tyr Thr Cys Tyr Glu His Val Trp
        835                 840                 845             
Thr Leu Ser Trp Ser Thr Gln Ile Gly Asp Leu Pro Asn Phe Ile Arg
    850                 855                 860                 
Val Ser Asp Glu Asn Leu Thr Gly Val Asn Pro Ala Ala Ala Thr Arg
865                 870                 875                 880 
Val Val Tyr Asp Gly Gly Val Phe Leu Gly Pro Ile Phe Gly Asp Met
                885                 890                 895     
Leu Ala Thr Ala Asn Gln His Thr Gln Val Val Val Arg Val Asn Asp
            900                 905                 910         
Val Pro Ala His Cys Pro Gly Ser Cys Ser Phe Gln Tyr Leu Gln Gly
        915                 920                 925             
Ser Thr Pro Cys Val His Ser Val Trp Tyr Ser Ile Asp Gly Asp Ile
    930                 935                 940                 
Asn Leu Met Ile Tyr Ile Thr Gly Thr Gly Phe Ser Gly Asp Ser Gln
945                 950                 955                 960 
Phe Leu Gln Val Thr Val Asn Lys Thr Ser Cys Lys Val Ile Phe Ser
                965                 970                 975     
Asn Gln Thr Asn Val Val Cys Gln Thr Asp Leu Leu Pro Val Gly Met
            980                 985                 990         
His Arg Ile Leu Met Leu Val Arg Pro Ser Gly Leu Ala Ile Ser Ala
        995                 1000                1005            
Thr Gly Glu Asp Leu Phe Leu Asn Val Lys Pro Arg Leu Asp Met Val
    1010                1015                1020                
Glu Pro Ser Arg Ala Ala Asp Ile Gly Gly Leu Trp Ala Thr Ile Arg
1025                1030                1035                1040
Gly Ser Ser Leu Glu Gly Val Ser Leu Ile Leu Phe Gly Ser Tyr Ser
                1045                1050                1055    
Cys Ala Ile Asn Val Ala Thr Ser Asn Ser Ser Arg Ile Gln Cys Lys
            1060                1065                1070        
Val Pro Pro Arg Gly Lys Asp Gly Arg Ile Val Asn Val Thr Val Ile
        1075                1080                1085            
Arg Gly Asp Tyr Ser Ala Val Leu Pro Arg Ala Phe Thr Tyr Val Ser
    1090                1095                1100                
Ser Leu Asn Pro Val Ile Val Thr Leu Ser Arg Asn Ile Ser Asn Ile
1105                1110                1115                1120
Ala Gly Gly Glu Thr Leu Val Ile Gly Val Ala Arg Leu Met Asn Tyr
                1125                1130                1135    
Thr Asp Leu Asp Val Glu Val His Val Gln Asp Ala Leu Ala Pro Val
            1140                1145                1150        
His Thr Gln Ser Ala Trp Gly Leu Glu Val Ala Leu Pro Pro Leu Pro
        1155                1160                1165            
Ala Gly Leu His Arg Ile Ser Val Ser Ile Asn Gly Val Ser Ile His
    1170                1175                1180                
Ser Gln Gly Val Asp Leu His Ile Gln Tyr Leu Thr Glu Val Phe Ser
1185                1190                1195                1200
Ile Glu Pro Cys Cys Gly Ser Leu Leu Gly Gly Thr Ile Leu Ser Ile
                1205                1210                1215    
Ser Gly Ile Gly Phe Ser Arg Asp Pro Ala Leu Val Trp Val Leu Val
            1220                1225                1230        
Gly Asn Arg Ser Cys Asp Ile Val Asn Leu Thr Glu Ala Ser Ile Trp
        1235                1240                1245            
Cys Glu Thr Leu Pro Ala Pro Gln Ile Pro Asp Ala Gly Ala Pro Thr
    1250                1255                1260                
Val Pro Ala Ala Val Glu Val Trp Ala Gly Asn Arg Phe Phe Ala Arg
1265                1270                1275                1280
Gly Pro Ser Pro Ser Leu Val Gly Lys Gly Phe Thr Phe Met Tyr Glu
                1285                1290                1295    
Ala Ala Ala Thr Pro Val Val Thr Ala Met Gln Gly Glu Ile Thr Asn
            1300                1305                1310        
Ser Ser Leu Ser Leu His Val Gly Gly Ser Asn Leu Ser Asn Ser Val
        1315                1320                1325            
Ile Leu Leu Gly Asn Leu Asn Cys Asp Val Glu Thr Gln Ser Phe Gln
    1330                1335                1340                
Gly Asn Val Ser Leu Ser Gly Cys Ser Ile Pro Leu His Ser Leu Glu
1345                1350                1355                1360
Ala Gly Ile Tyr Pro Leu Gln Val Arg Gln Lys Gln Met Gly Phe Ala
                1365                1370                1375    
Asn Met Ser Val Val Leu Gln Gln Phe Ala Val Met Pro Arg Ile Met
            1380                1385                1390        
Ala Ile Phe Pro Ser Gln Gly Ser Ala Cys Gly Gly Thr Ile Leu Thr
        1395                1400                1405            
Val Arg Gly Leu Leu Leu Asn Ser Arg Arg Arg Ser Val Arg Val Asp
    1410                1415                1420                
Leu Ser Gly Pro Phe Thr Cys Val Ile Leu Ser Leu Gly Asp His Thr
1425                1430                1435                1440
Ile Leu Cys Gln Val Ser Leu Glu Gly Asp Pro Leu Pro Gly Ala Ser
                1445                1450                1455    
Phe Ser Leu Asn Val Thr Val Leu Val Asn Gly Leu Thr Ser Glu Cys
            1460                1465                1470        
Gln Gly Asn Cys Thr Leu Phe Ile Arg Glu Glu Ala Ser Pro Val Met
        1475                1480                1485            
Asp Ala Leu Ser Thr Asn Thr Ser Gly Ser Leu Thr Thr Val Leu Ile
    1490                1495                1500                
Arg Gly Gln Arg Leu Ala Thr Thr Ala Asp Glu Pro Met Val Phe Val
1505                1510                1515                1520
Asp Asp Gln Leu Pro Cys Asn Val Thr Phe Phe Asn Ala Ser His Val
                1525                1530                1535    
Val Cys Gln Thr Arg Asp Leu Ala Pro Gly Pro His Tyr Leu Ser Val
            1540                1545                1550        
Phe Tyr Thr Arg Asn Gly Tyr Ala Cys Ser Gly Asn Val Ser Arg His
        1555                1560                1565            
Phe Tyr Ile Met Pro Gln Val Phe His Tyr Phe Pro Lys Asn Phe Ser
    1570                1575                1580                
Leu His Gly Gly Ser Leu Leu Thr Ile Glu Gly Thr Gly Leu Arg Gly
1585                1590                1595                1600
Gln Asn Thr Thr Ser Val Tyr Ile Asp Gln Gln Thr Cys Leu Thr Val
                1605                1610                1615    
Asn Ile Gly Ala Glu Leu Ile Arg Cys Ile Val Pro Thr Gly Asn Gly
            1620                1625                1630        
Ser Val Ala Leu Glu Ile Glu Val Asp Gly Leu Trp Tyr His Ile Gly
        1635                1640                1645            
Val Ile Gly Tyr Asn Lys Ala Phe Thr Pro Glu Leu Ile Ser Ile Ser
    1650                1655                1660                
Gln Ser Asp Asp Ile Leu Thr Phe Ala Val Ala Gln Ile Ser Gly Ala
1665                1670                1675                1680
Ala Asn Ile Asp Ile Phe Ile Gly Met Ser Pro Cys Val Gly Val Ser
                1685                1690                1695    
Gly Asn His Thr Val Leu Gln Cys Val Val Pro Ser Leu Pro Ala Gly
            1700                1705                1710        
Glu Tyr His Val Arg Gly Tyr Asp Cys Ile Arg Gly Trp Ala Ser Ser
        1715                1720                1725            
Ala Leu Val Phe Thr Ser Arg Val Ile Ile Thr Ala Val Thr Glu Asn
    1730                1735                1740                
Phe Gly Cys Leu Gly Gly Arg Leu Val His Val Phe Gly Ala Gly Phe
1745                1750                1755                1760
Ser Pro Gly Asn Val Ser Ala Ala Val Cys Gly Ala Pro Cys Arg Val
                1765                1770                1775    
Leu Ala Asn Ala Thr Val Ser Ala Phe Ser Cys Leu Val Leu Pro Leu
            1780                1785                1790        
Asp Val Ser Leu Ala Phe Leu Cys Gly Leu Lys Arg Glu Glu Asp Ser
        1795                1800                1805            
Cys Glu Ala Ala Arg His Thr Tyr Val Gln Cys Asp Leu Thr Val Ala
    1810                1815                1820                
Met Ala Thr Glu Gln Leu Leu Glu Ser Trp Pro Tyr Leu Tyr Ile Cys
1825                1830                1835                1840
Glu Glu Ser Ser Gln Cys Leu Phe Val Pro Asp His Trp Ala Glu Ser
                1845                1850                1855    
Met Phe Pro Ser Phe Ser Gly Leu Phe Ile Ser Pro Lys Leu Glu Arg
            1860                1865                1870        
Asp Glu Val Leu Ile Tyr Asn Ser Ser Cys Asn Ile Thr Met Glu Thr
        1875                1880                1885            
Glu Ala Glu Met Glu Cys Glu Thr Pro Asn Gln Pro Ile Thr Val Lys
    1890                1895                1900                
Ile Thr Glu Ile Arg Lys Arg Trp Gly Gln Asn Thr Gln Gly Asn Phe
1905                1910                1915                1920
Ser Leu Gln Phe Cys Arg Arg Trp Ser Arg Thr His Ser Trp Phe Pro
                1925                1930                1935    
Glu Arg Leu Pro Gln Asp Gly Asp Asn Val Thr Val Glu Asn Gly Gln
            1940                1945                1950        
Leu Leu Leu Leu Asp Thr Asn Thr Ser Ile Leu Asn Leu Leu His Ile
        1955                1960                1965            
Lys Gly Gly Lys Leu Ile Phe Met Ala Pro Gly Pro Ile Glu Leu Arg
    1970                1975                1980                
Ala His Ala Ile Leu Val Ser Asp Gly Gly Glu Leu Arg Ile Gly Ser
1985                1990                1995                2000
Glu Asp Lys Pro Phe Gln Gly Arg Ala Gln Ile Thr Leu Tyr Gly Ser
                2005                2010                2015    
Ser Tyr Ser Thr Pro Phe Phe Pro Tyr Gly Val Lys Phe Leu Ala Val
            2020                2025                2030        
Arg Asn Gly Thr Leu Ser Leu His Gly Ser Leu Pro Glu Val Ile Val
        2035                2040                2045            
Thr Cys Leu Arg Ala Thr Ala His Ala Leu Asp Thr Val Leu Ala Leu
    2050                2055                2060                
Glu Asp Ala Val Asp Trp Asn Pro Gly Asp Glu Val Val Ile Ile Ser
2065                2070                2075                2080
Gly Thr Gly Val Lys Gly Ala Lys Pro Met Glu Glu Ile Val Thr Val
                2085                2090                2095    
Glu Thr Val Gln Asp Thr Asp Leu Tyr Leu Lys Ser Pro Leu Arg Tyr
            2100                2105                2110        
Ser His Asn Phe Thr Glu Asn Trp Val Ala Gly Glu His His Ile Leu
        2115                2120                2125            
Lys Ala Thr Val Ala Leu Leu Ser Arg Ser Ile Thr Ile Gln Gly Asn
    2130                2135                2140                
Leu Thr Asn Glu Arg Glu Lys Leu Leu Val Ser Cys Gln Glu Ala Asn
2145                2150                2155                2160
Ala Pro Glu Gly Asn Leu Gln His Cys Leu Tyr Ser Met Ser Glu Lys
                2165                2170                2175    
Met Leu Gly Ser Arg Asp Met Gly Ala Arg Val Ile Val Gln Ser Phe
            2180                2185                2190        
Pro Glu Glu Pro Ser Gln Val Gln Leu Lys Gly Val Gln Phe Gln Val
        2195                2200                2205            
Leu Gly Gln Ala Phe His Lys His Leu Ser Ser Leu Thr Leu Val Gly
    2210                2215                2220                
Ala Met Arg Glu Ser Phe Ile Gln Gly Cys Thr Val Arg Asn Ser Phe
2225                2230                2235                2240
Ser Arg Gly Leu Ser Met Cys Gly Thr Leu Gly Leu Lys Val Asp Ser
                2245                2250                2255    
Asn Val Phe Tyr Asn Ile Leu Gly His Ala Leu Leu Val Gly Thr Cys
            2260                2265                2270        
Thr Glu Met Arg Tyr Ile Ser Trp Glu Ala Ile His Gly Arg Lys Asp
        2275                2280                2285            
Asp Trp Ser Gly His Gly Asn Ile Ile Arg Asn Asn Val Ile Ile Gln
    2290                2295                2300                
Val Ser Gly Ala Glu Gly Leu Ser Asn Pro Glu Met Leu Thr Pro Ser
2305                2310                2315                2320
Gly Ile Tyr Ile Cys Ser Pro Thr Asn Val Ile Glu Gly Asn Arg Val
                2325                2330                2335    
Cys Gly Ala Gly Tyr Gly Tyr Phe Phe His Leu Met Thr Asn Gln Thr
            2340                2345                2350        
Ser Gln Ala Pro Leu Leu Ser Phe Thr Gln Asn Ile Ala His Ser Cys
        2355                2360                2365            
Thr Arg Tyr Gly Leu Phe Val Tyr Pro Lys Phe Gln Pro Pro Trp Asp
    2370                2375                2380                
Asn Val Thr Gly Thr Thr Leu Phe Gln Ser Phe Thr Val Trp Glu Ser
2385                2390                2395                2400
Ala Gly Gly Ala Gln Ile Phe Arg Ser Ser Asn Leu Arg Leu Lys Asn
                2405                2410                2415    
Phe Lys Val Tyr Ser Cys Arg Asp Phe Gly Ile Asp Val Leu Glu Ser
            2420                2425                2430        
Asp Ala Asn Thr Ser Val Thr Asp Ser Leu Leu Leu Gly His Phe Ala
        2435                2440                2445            
His Lys Gly Ser Leu Cys Met Ser Ser Gly Ile Lys Thr Pro Lys Arg
    2450                2455                2460                
Trp Glu Leu Met Val Ser Asn Thr Thr Phe Val Asn Phe Asp Leu Ile
2465                2470                2475                2480
Asn Cys Val Ala Ile Arg Thr Cys Ser Asp Cys Ser Gln Gly Gln Gly
                2485                2490                2495    
Gly Phe Thr Val Lys Thr Ser Gln Leu Lys Phe Thr Asn Ser Ser Asn
            2500                2505                2510        
Leu Val Ala Phe Pro Phe Pro His Ala Ala Ile Leu Glu Asp Leu Asp
        2515                2520                2525            
Gly Ser Leu Ser Gly Lys Asn Arg Ser His Ile Leu Ala Ser Met Glu
    2530                2535                2540                
Thr Leu Ser Ala Ser Cys Leu Val Asn Ser Ser Phe Gly Arg Val Val
2545                2550                2555                2560
His Gly Ser Ala Cys Gly Gly Gly Val Leu Phe His Arg Met Ser Ile
                2565                2570                2575    
Gly Leu Ala Asn Thr Pro Glu Val Ser Tyr Asp Leu Thr Met Thr Asp
            2580                2585                2590        
Ser Arg Asn Lys Thr Thr Thr Val Asn Tyr Val Arg Asp Thr Leu Ser
        2595                2600                2605            
Asn Pro Arg Gly Trp Met Ala Leu Leu Leu Asp Gln Glu Thr Tyr Ser
    2610                2615                2620                
Leu Gln Ser Glu Asn Leu Trp Ile Asn Arg Ser Leu Gln Tyr Ser Ala
2625                2630                2635                2640
Thr Phe Asp Asn Phe Ala Pro Gly Asn Tyr Leu Leu Leu Val His Thr
                2645                2650                2655    
Asp Leu Pro Pro Tyr Pro Asp Ile Leu Leu Arg Cys Gly Ser Arg Val
            2660                2665                2670        
Gly Leu Ser Phe Pro Phe Leu Pro Ser Pro Gly Gln Asn Gln Gly Cys
        2675                2680                2685            
Asp Trp Phe Phe Asn Ser Gln Leu Arg Gln Leu Thr Tyr Leu Val Ser
    2690                2695                2700                
Gly Glu Gly Gln Val Gln Val Ile Leu Arg Val Lys Glu Gly Met Pro
2705                2710                2715                2720
Pro Thr Ile Ser Ala Ser Thr Ser Ala Pro Glu Ser Ala Leu Lys Trp
                2725                2730                2735    
Ser Leu Pro Glu Thr Trp Gln Gly Val Glu Glu Gly Trp Gly Gly Tyr
            2740                2745                2750        
Asn Asn Thr Ile Pro Gly Pro Gly Asp Asp Val Leu Ile Leu Pro Asn
        2755                2760                2765            
Arg Thr Val Leu Val Asp Thr Asp Leu Pro Phe Phe Lys Gly Leu Tyr
    2770                2775                2780                
Val Met Gly Thr Leu Asp Phe Pro Val Asp Arg Ser Asn Val Leu Ser
2785                2790                2795                2800
Val Ala Cys Met Val Ile Ala Gly Gly Glu Leu Lys Val Gly Thr Leu
                2805                2810                2815    
Glu Asn Pro Leu Glu Lys Glu Gln Lys Leu Leu Ile Leu Leu Arg Ala
            2820                2825                2830        
Ser Glu Gly Val Phe Cys Asp Arg Met Asn Gly Ile His Ile Asp Pro
        2835                2840                2845            
Gly Thr Ile Gly Val Tyr Gly Lys Val His Leu Tyr Ser Ala Tyr Pro
    2850                2855                2860                
Lys Asn Ser Trp Thr His Leu Gly Ala Asp Ile Ala Ser Gly Asn Glu
2865                2870                2875                2880
Arg Ile Ile Val Glu Asp Ala Val Asp Trp Arg Pro His Asp Lys Ile
                2885                2890                2895    
Val Leu Ser Ser Ser Ser Tyr Glu Pro His Glu Ala Glu Val Leu Thr
            2900                2905                2910        
Val Lys Glu Val Lys Gly His His Val Arg Ile Tyr Glu Arg Leu Lys
        2915                2920                2925            
His Arg His Ile Gly Ser Val His Val Thr Glu Asp Gly Arg His Ile
    2930                2935                2940                
Arg Leu Ala Ala Glu Val Gly Leu Leu Thr Arg Asn Ile Gln Ile Gln
2945                2950                2955                2960
Pro Asp Val Ser Cys Arg Gly Arg Leu Phe Val Gly Ser Phe Arg Lys
                2965                2970                2975    
Ser Ser Arg Glu Glu Phe Ser Gly Val Leu Gln Leu Leu Asn Val Glu
            2980                2985                2990        
Ile Gln Asn Phe Gly Ser Pro Leu Tyr Ser Ser Val Glu Phe Ser Asn
        2995                3000                3005            
Val Ser Ala Gly Ser Trp Ile Ile Ser Ser Thr Leu His Gln Ser Cys
    3010                3015                3020                
Gly Gly Gly Ile His Ala Ala Ala Ser His Gly Val Leu Leu Asn Asp
3025                3030                3035                3040
Asn Ile Val Phe Gly Thr Ala Gly His Gly Ile Asp Leu Glu Gly Gln
                3045                3050                3055    
Ala Tyr Thr Val Thr Asn Asn Leu Val Val Leu Met Thr Gln Pro Ala
            3060                3065                3070        
Trp Ser Thr Ile Trp Val Ala Gly Ile Lys Val Asn Gln Val Lys Asp
        3075                3080                3085            
Ile Asn Leu His Gly Asn Val Val Ala Gly Ser Glu Arg Leu Gly Phe
    3090                3095                3100                
His Ile Arg Gly His Lys Cys Ser Ser Cys Glu Leu Leu Trp Ser Asp
3105                3110                3115                3120
Asn Val Ala His Ser Ser Leu His Gly Leu His Leu Tyr Lys Glu Ser
                3125                3130                3135    
Gly Leu Asp Asn Cys Thr Arg Ile Ser Gly Phe Leu Ala Phe Lys Asn
            3140                3145                3150        
Phe Asp Tyr Gly Ala Met Leu His Val Glu Asn Ser Val Glu Ile Glu
        3155                3160                3165            
Asn Ile Thr Leu Val Asp Asn Thr Ile Gly Leu Leu Ala Val Val Tyr
    3170                3175                3180                
Val Phe Ser Ala Pro Gln Asn Ser Val Lys Lys Val Gln Ile Val Leu
3185                3190                3195                3200
Arg Asn Ser Val Ile Val Ala Thr Ser Ser Ser Phe Asp Cys Ile Gln
                3205                3210                3215    
Asp Lys Val Lys Pro His Ser Ala Asn Leu Thr Ser Thr Asp Arg Ala
            3220                3225                3230        
Pro Ser Asn Pro Arg Gly Gly Arg Ile Gly Ile Leu Trp Pro Val Phe
        3235                3240                3245            
Thr Ser Glu Pro Asn Gln Trp Pro Gln Glu Pro Trp His Lys Val Arg
    3250                3255                3260                
Asn Asp His Ser Ile Ser Gly Ile Met Lys Leu Gln Asp Val Thr Phe
3265                3270                3275                3280
Ser Ser Phe Val Lys Ser Cys Tyr Ser Asp Asp Leu Asp Val Cys Ile
                3285                3290                3295    
Leu Pro Asn Ala Glu Asn Ser Gly Ile Met His Pro Ile Thr Ala Glu
            3300                3305                3310        
Arg Thr Arg Met Leu Lys Ile Lys Asp Lys Asn Lys Phe Tyr Phe Pro
        3315                3320                3325            
Ser Leu Gln Pro Arg Lys Asp Leu Gly Lys Val Val Cys Pro Glu Leu
    3330                3335                3340                
Asp Cys Ala Ser Pro Arg Lys Tyr Leu Phe Lys Asp Leu Asp Gly Arg
3345                3350                3355                3360
Ala Leu Gly Leu Pro Pro Pro Val Ser Val Phe Pro Lys Thr Glu Ala
                3365                3370                3375    
Glu Trp Thr Ala Ser Phe Phe Asn Ala Gly Thr Phe Arg Glu Glu Gln
            3380                3385                3390        
Lys Cys Thr Tyr Gln Phe Leu Met Gln Gly Phe Ile Cys Lys Gln Thr
        3395                3400                3405            
Asp Gln Val Val Leu Ile Leu Asp Ser Ala Asp Ala Ile Trp Ala Ile
    3410                3415                3420                
Gln Lys Leu Tyr Pro Val Val Ser Val Thr Ser Gly Phe Val Asp Val
3425                3430                3435                3440
Phe Ser Ser Val Asn Ala Asn Ile Pro Cys Ser Thr Ser Gly Ser Val
                3445                3450                3455    
Ser Thr Phe Tyr Ser Ile Leu Pro Ile Arg Gln Ile Thr Lys Val Cys
            3460                3465                3470        
Phe Met Asp Gln Thr Pro Gln Val Leu Arg Phe Phe Leu Leu Gly Asn
        3475                3480                3485            
Lys Ser Thr Ser Lys Leu Leu Leu Ala Val Phe Tyr His Glu Leu Gln
    3490                3495                3500                
Ser Pro His Val Phe Leu Gly Glu Ser Phe Ile Pro Pro Thr Leu Val
3505                3510                3515                3520
Gln Ser Ala Ser Leu Leu Leu Asn Glu Ser Ile Gly Ala Asn Tyr Phe
                3525                3530                3535    
Asn Ile Met Asp Asn Leu Leu Tyr Val Val Leu Gln Gly Glu Glu Pro
            3540                3545                3550        
Ile Glu Ile Arg Ser Gly Val Ser Ile His Leu Ala Leu Thr Val Met
        3555                3560                3565            
Val Ser Val Leu Glu Lys Gly Trp Glu Ile Val Ile Leu Glu Arg Leu
    3570                3575                3580                
Thr Asn Phe Leu Gln Ile Gly Gln Asn Gln Ile Arg Phe Ile His Glu
3585                3590                3595                3600
Met Pro Gly His Glu Glu Thr Leu Lys Ala Ile Ala Asp Ser Arg Ala
                3605                3610                3615    
Lys Arg Lys Arg Asn Cys Pro Thr Val Thr Cys Thr Ser His Tyr Arg
            3620                3625                3630        
Arg Val Gly Gln Arg Arg Pro Leu Met Met Glu Met Asn Ser His Arg
        3635                3640                3645            
Ala Ser Pro Pro Met Thr Val Glu Thr Ile Ser Lys Val Ile Val Ile
    3650                3655                3660                
Glu Ile Gly Asp Ser Pro Thr Val Arg Ser Thr Gly Met Ile Ser Ser
3665                3670                3675                3680
Leu Ser Ser Asn Lys Leu Gln Asn Leu Ala His Arg Val Ile Thr Ala
                3685                3690                3695    
Gln Gln Thr Gly Val Leu Glu Asn Val Leu Asn Met Thr Ile Gly Ala
            3700                3705                3710        
Leu Leu Val Thr Gln Ser Lys Gly Val Ile Gly Tyr Gly Asn Thr Ser
        3715                3720                3725            
Ser Phe Lys Thr Gly Asn Leu Ile Tyr Ile Arg Pro Tyr Ala Leu Ser
    3730                3735                3740                
Ile Leu Val Gln Pro Ser Asp Gly Glu Val Gly Asn Glu Leu Pro Val
3745                3750                3755                3760
Gln Pro Gln Leu Val Phe Leu Asp Glu Gln Asn Arg Arg Val Glu Ser
                3765                3770                3775    
Leu Gly Pro Pro Ser Glu Pro Trp Thr Ile Ser Ala Ser Leu Glu Gly
            3780                3785                3790        
Ala Ser Asp Ser Val Leu Lys Gly Cys Thr Gln Ala Glu Thr Gln Asp
        3795                3800                3805            
Gly Tyr Val Ser Phe Tyr Asn Leu Ala Val Leu Ile Ser Gly Ser Asn
    3810                3815                3820                
Trp His Phe Ile Phe Thr Val Thr Ser Pro Pro Gly Val Asn Phe Thr
3825                3830                3835                3840
Ala Arg Ser Lys Pro Phe Ala Val Leu Pro Val Thr Arg Lys Glu Lys
                3845                3850                3855    
Ser Thr Ile Ile Leu Ala Ala Ser Leu Ser Ser Val Ala Ser Trp Leu
            3860                3865                3870        
Ala Leu Ser Cys Leu Val Cys Cys Trp Leu Lys Arg Ser Lys Ser Arg
        3875                3880                3885            
Lys Thr Lys Pro Glu Glu Ile Pro Glu Ser Gln Thr Asn Asn Gln Asn
    3890                3895                3900                
Ile His Ile His Ile Ser Ser Lys Arg Arg Glu Ser Gln Gly Pro Lys
3905                3910                3915                3920
Lys Glu Asp Thr Val Val Gly Glu Asp Met Arg Met Lys Val Met Leu
                3925                3930                3935    
Gly Lys Val Asn Gln Cys Pro His Gln Leu Met Asn Gly Val Ser Arg
            3940                3945                3950        
Arg Lys Val Ser Arg His Ile Val Arg Glu Glu Glu Ala Ala Val Pro
        3955                3960                3965            
Ala Pro Gly Thr Thr Gly Ile Thr Ser His Gly His Ile Cys Ala Pro
    3970                3975                3980                
Gly Ala Pro Ala Gln Gln Val Tyr Leu Gln Glu Thr Gly Asn Trp Lys
3985                3990                3995                4000
Glu Gly Gln Glu Gln Leu Leu Arg Tyr Gln Leu Ala Gly Gln Asn Gln
                4005                4010                4015    
Leu Leu Leu Leu Cys Pro Asp Phe Arg Gln Glu Arg Gln Gln Leu Pro
            4020                4025                4030        
Gly Gln Ser Arg Leu Ser Lys Gln Ser Gly Ser Leu Gly Leu Ser Gln
        4035                4040                4045            
Glu Lys Lys Ala Ser Cys Gly Ala Thr Glu Ala Phe Cys Leu His Ser
    4050                4055                4060                
Val His Pro Glu Thr Ile Gln Glu Gln Leu
4065                4070                


<210> 3025
<211> 615
<212> PRT
<213> Homo sapiens

<400> 3025
Arg Val Thr Ser Arg Ser Gly Pro Ala Pro Ala Arg Arg Asn Ser Val
 1               5                  10                  15      
Thr Thr Gly Tyr Gly Gly Val Arg Ala Leu Cys Gly Trp Thr Pro Ser
            20                  25                  30          
Ser Gly Ala Thr Pro Arg Asn Arg Leu Leu Leu Gln Leu Leu Gly Ser
        35                  40                  45              
Pro Gly Arg Arg Tyr Tyr Ser Leu Pro Pro His Gln Lys Val Pro Leu
    50                  55                  60                  
Pro Ser Leu Ser Pro Thr Met Gln Ala Gly Thr Ile Ala Arg Trp Lys
65                  70                  75                  80  
Lys Lys Glu Gly Asp Lys Ile Asn Glu Gly Asp Leu Ile Ala Glu Val
                85                  90                  95      
Glu Thr Asp Lys Ala Thr Val Gly Phe Glu Ser Leu Glu Glu Cys Tyr
            100                 105                 110         
Met Ala Lys Ile Leu Val Ala Glu Gly Thr Arg Asp Val Pro Ile Gly
        115                 120                 125             
Ala Ile Ile Cys Ile Thr Val Gly Lys Pro Glu Asp Ile Glu Ala Phe
    130                 135                 140                 
Lys Asn Tyr Thr Leu Asp Ser Ser Ala Ala Pro Thr Pro Gln Ala Ala
145                 150                 155                 160 
Pro Ala Pro Thr Pro Ala Ala Thr Ala Ser Pro Pro Thr Pro Ser Ala
                165                 170                 175     
Gln Ala Pro Gly Ser Ser Tyr Pro Pro His Met Gln Val Leu Leu Pro
            180                 185                 190         
Ala Leu Ser Pro Thr Met Thr Met Gly Thr Val Gln Arg Trp Glu Lys
        195                 200                 205             
Lys Val Gly Glu Lys Leu Ser Glu Gly Asp Leu Leu Ala Glu Ile Glu
    210                 215                 220                 
Thr Asp Lys Ala Thr Ile Gly Phe Glu Val Gln Glu Glu Gly Tyr Leu
225                 230                 235                 240 
Ala Lys Ile Leu Val Pro Glu Gly Thr Arg Asp Val Pro Leu Gly Thr
                245                 250                 255     
Pro Leu Cys Ile Ile Val Glu Lys Glu Ala Asp Ile Ser Ala Phe Ala
            260                 265                 270         
Asp Tyr Arg Pro Thr Glu Val Thr Asp Leu Lys Pro Gln Val Pro Pro
        275                 280                 285             
Pro Thr Pro Pro Pro Val Ala Ala Val Pro Pro Thr Pro Gln Pro Leu
    290                 295                 300                 
Ala Pro Thr Pro Ser Ala Pro Cys Pro Ala Thr Pro Ala Gly Pro Lys
305                 310                 315                 320 
Gly Arg Val Phe Val Ser Pro Leu Ala Lys Lys Leu Ala Val Glu Lys
                325                 330                 335     
Gly Ile Asp Leu Thr Gln Val Lys Gly Thr Gly Pro Asp Gly Arg Ile
            340                 345                 350         
Thr Lys Lys Asp Ile Asp Ser Phe Val Pro Ser Lys Val Ala Pro Ala
        355                 360                 365             
Pro Ala Ala Val Val Pro Pro Thr Gly Pro Gly Met Ala Pro Val Pro
    370                 375                 380                 
Thr Gly Val Phe Thr Asp Ile Pro Ile Ser Asn Ile Arg Arg Val Ile
385                 390                 395                 400 
Ala Gln Arg Leu Met Gln Ser Lys Gln Thr Ile Pro His Tyr Tyr Leu
                405                 410                 415     
Ser Ile Asp Val Asn Met Gly Glu Val Leu Leu Val Arg Lys Glu Leu
            420                 425                 430         
Asn Lys Ile Leu Glu Gly Arg Ser Lys Ile Ser Val Asn Asp Phe Ile
        435                 440                 445             
Ile Lys Ala Ser Ala Leu Ala Cys Leu Lys Val Pro Glu Ala Asn Ser
    450                 455                 460                 
Ser Trp Met Asp Thr Val Ile Arg Gln Asn His Val Val Asp Val Ser
465                 470                 475                 480 
Val Ala Val Ser Thr Pro Ala Gly Leu Ile Thr Pro Ile Val Phe Asn
                485                 490                 495     
Ala His Ile Lys Gly Val Glu Thr Ile Ala Asn Asp Val Val Ser Leu
            500                 505                 510         
Ala Thr Lys Ala Arg Glu Gly Lys Leu Gln Pro His Glu Phe Gln Gly
        515                 520                 525             
Gly Thr Phe Thr Ile Ser Asn Leu Gly Met Phe Gly Ile Lys Asn Phe
    530                 535                 540                 
Ser Ala Ile Ile Asn Pro Pro Gln Ala Cys Ile Leu Ala Ile Gly Ala
545                 550                 555                 560 
Ser Glu Asp Lys Leu Val Pro Ala Asp Asn Glu Lys Gly Arg Asp Val
                565                 570                 575     
Ala Ser Met Met Ser Val Thr Leu Ser Cys Asp His Arg Val Val Asp
            580                 585                 590         
Gly Ala Val Gly Ala Gln Trp Leu Ala Glu Phe Arg Lys Tyr Leu Glu
        595                 600                 605             
Lys Pro Ile Thr Met Leu Leu
    610                 615 

